Patent Publication Number: US-11642451-B2

Title: Medical injection device packaging

Description:
CROSS-REFERENCE TO RELATED APPLICATION 
     This application claims the benefit of Great Britain Patent Application No. 1621275.5 filed on Dec. 14, 2016, the disclosure of which is incorporated herein by reference in its entirety. 
     TECHNICAL FIELD 
     The present disclosure relates generally to the field of medical packaging for containing medical injection devices and in particular medical tray type packaging for containing said devices. 
     BACKGROUND 
     Medical tray type packaging of the type for containing a medical injection device commonly comprises a thermoformed tray formed from a plastic sheet. The plastic sheet is formed to extend around the device. To close the tray a tear away or break through lid may be provided as medical blister type packaging. Alternatively, the lid formed of a corresponding plastic sheet may be arranged as medical clamshell type packaging. 
     Medical tray type packaging may differ from traditional pharmaceutical blister packaging for unit-dose packaging of tablets in that, for protection of the device, the tray is not collapsible. The device therefore cannot be pushed-though for extraction. Consequently, a process for extraction of a device from a tray can be more complex. It may comprise removal/perforation of the lid and a user reaching into part of the channel and gripping the device. The channel may be narrow and difficult to access, particularly for users who have and illness reducing their dexterity. 
     In spite of the effort already invested in the development of said packaging, further improvements are desirable. 
    
    
     
       BRIEF DESCRIPTION OF THE FIGURES 
       Aspects, features and advantages of embodiments of the present disclosure will become apparent from the following description of embodiments in reference to the appended drawings in which like numerals denote like elements. 
         FIG.  1    is an exploded schematic perspective diagram showing an embodiment packaging and an embodiment injection device, wherein a positioning recess of the injection device is shown in hidden line. 
         FIG.  2    is a side schematic diagram showing the embodiment packaging of  FIG.  1    accommodating the injection device of  FIG.  1   , wherein the injection device is shown in hidden line. 
         FIG.  3    is a plan schematic diagram showing embodiments of the packaging of  FIG.  1   . 
         FIG.  4    is a plan view showing a planform of embodiment packaging. 
         FIG.  5    is a side view showing the embodiment packaging of  FIG.  4   . 
         FIG.  6    is a front sectional view showing the embodiment packaging of  FIG.  4   . 
         FIG.  7    is a perspective view showing the embodiment packaging of  FIG.  4   . 
         FIG.  8    is a front sectional view showing an embodiment positioning rib of the packaging accommodated in an embodiment positioning recess of an embodiment injection device. 
         FIG.  9    is a front sectional view showing an embodiment positioning rib of the packaging accommodated in an embodiment positioning recess of an embodiment injection device. 
         FIG.  10    is a front sectional view showing an embodiment positioning rib of packaging accommodated in an embodiment positioning recess of an embodiment injection device. 
         FIG.  11    is a side sectional view showing an embodiment positioning rib of the packaging accommodated in an embodiment positioning recess of an embodiment injection device. 
         FIGS.  12  and  13    are perspective views showing a portion of the embodiment packaging of  FIG.  4   . 
         FIG.  14    is a perspective cut-away view showing abutment between stacked packaging of the embodiment packaging of  FIG.  4    and an injection device accommodated in the packaging. 
         FIG.  15    is a perspective cut away view showing stacked packaging extending in a longitudinal direction, the packaging of the embodiment packaging of  FIG.  4   . 
         FIG.  16    is a perspective cut away view showing a peripheral lateral wall of stacked packaging, the packaging of the embodiment packaging of  FIG.  4   . 
         FIG.  17    is a perspective view showing stacked packaging, the packaging of the embodiment packaging of  FIG.  4   . 
     
    
    
     DETAILED DESCRIPTION OF EMBODIMENTS 
     Before describing embodiments of the packaging, it is to be understood that the packing is not limited to the details of construction or process steps set forth in the following description. It will be apparent to those skilled in the art having the benefit of the present disclosure that the packaging is capable of other embodiments and of being practiced or being carried out in various ways. 
     Accordingly, the embodiments are merely examples and should not be construed to narrow the scope or spirit of the subject matter described herein in any way. Moreover, the embodiments may be combined in any suitable combination to provide further embodiments. 
     The present disclosure may be better understood in view of the following explanations: 
     As used herein, the terms “package” or “packaging” may encompass any arrangement to wrap or protect an injection device. Packaging can be rigid or flexible. Packaging may include blister packs, medical clamshell, clamshell trays, medical trays and other like arrangements. The packaging may be sterile or nonsterile. 
     As used herein, the term “injection device” may include a device for the injection of a medicament to a body of a human or animal subject and includes devices configured for various delivery methods, such as intradermal, subcutaneous, intramuscular, intravenous, intraosseous, intraperitoneal, intrathecal, epidural, intracardiac, intraarticular, intracavernous, intravitreal or other like method. Injection device includes syringes of all types, devices that contain said syringes such as auto-injectors, pen-injectors and other like devices. 
     As used herein, the term “auto-injector” may include any device configured to deliver a dose of a medicament from a prefilled syringe. The auto-injector may be configured to deliver a single dose of a medicament. Auto-injectors may include a device comprising a prefilled syringe that contains a medicament. The prefilled syringe may be embedded in the auto-injector, for example for a disposable device. In other embodiments, the prefilled syringe may be insertable in and removable from the auto-injector, for example for a multi-use device. The syringe may be spring, gas or otherwise actuated for said delivery. A presently available example is the DAI™ by SHL Group and the Ypsomate™ by Ypsomed. 
     As used herein, the term “pen-injector” may include any device configured to deliver a dose of a medicament from a cartridge. The delivery may be via spring, gas or otherwise actuated. 
     As used herein, the terms “grip” or “gripping” may include to hold by clasping or grasping with digits of hands of a user with a pincer type action. Grip includes a manner of gripping suitable for removing an injection device as defined herein from a channel as defined herein. Grip includes a user&#39;s opposed digits pressing against the injection device such that frictional forces are greater that the weight of the injection device or the force retaining the injection device in the channel. 
     The term “digits” may include reference to one or two fingers and an opposed thumb. The fingers are typically selected from the index finger, middle finger, ring finger. The size of user&#39;s fingers and thumb are within conventionally accepted ranges. In an example, user fingers and thumbs may be idealised as having a hemispherical tip that extends into a nominal circular cross-sectioned body. For fingers the body may have a diameter that may be 10-20 mm. For thumbs the body may have a diameter that may be 10-30 mm. Further hand dimensions may be as defined by http://usability.gtri.gatech.edu/eou_info/hand_anthro.php or similar hand/finger anthropometry study. 
     As used herein “user” is intended to refer to a healthcare professional, a medical practitioner, human end user or other human user associated therewith. 
     As used herein, the term “medicament” may include a substance, which may be in liquid form. The medicament can include a substance for use in the treatment or prevention of a disorder that causes reduced dexterity of a user, examples include multiple sclerosis, rheumatoid arthritis, muscular atrophy, Parkinson&#39;s disease, celiac disease, Alzheimer&#39;s disease. 
     In an embodiment medicament comprises Glatiramer acetate (GA). GA is a mixture of polypeptides which do not all have the same amino acid sequence GA is marketed under the tradename Copaxone®. GA comprises the acetate salts of polypeptides containing L-glutamic acid, L-alanine, L-tyrosine and L-lysine at average molar fractions of 0.141, 0.427, 0.095 and 0.338, respectively. The average molecular weight of Copaxone® is between 5,000 and 9,000 daltons. (“Copaxone”, Physician&#39;s Desk Reference, (2005), Medical Economics Co., Inc., (Montvale, N.J.), 3115.) Chemically, glatiramer acetate is designated L-glutamic acid polymer with L-alanine, L-lysine, L-tyrosine, acetate (salt). 
     In an embodiment medicament comprises an anti-TNFα antibody, preferably the anti-TNFα antibody is adalimumab. Adalimumab is marketed under the trade name Humira® and is described in U.S. Pat. No. 6,090,382. 
     In an embodiment the medicament comprises Follicle-stimulating hormone (FSH), also known as follitropin alfa. FHS is for the treatment of infertility. FSH is marketed under the following brands: Ovaleap® (Teva Pharma); Gonal-f® (Merck Serono); Puregon (Merck Sharp and Dohme), Bemfola (Finox Biotech), Elonva (Merck Sharp and Dohme). FSH is for use in the treatment of the following indications: anovulation (including polycystic ovarian syndrome) in women who have been unresponsive to treatment with clomifene citrate; stimulation of multifollicular development in women undergoing superovulation for assisted reproductive technologies (ART) such as in vitro fertilisation (IVF), gamete intra-fallopian transfer and zygote intra-fallopian transfer; FSH in association with a luteinising hormone (LH) preparation is for the stimulation of follicular development in women with severe LH and FSH deficiency, in clinical trials these patients were defined by an endogenous serum LH level &lt;1.2 IU/L; FSH is for use in the stimulation of spermatogenesis in men who have congenital or acquired hypogonadotropic hypogonadism with concomitant human chorionic gonadotropin (hCG) therapy. 
     In an embodiment the medicament comprises Reslizumab. Reslizumab is marketed as Cinqair®. Reslizumab is an interleukin-5 antagonist monoclonal antibody (IgG4 kappa) for use in add-on maintenance treatment of patients with severe asthma aged 18 years and older, and with an eosinophilic phenotype (1). Reslizumab is an FDA approved antibody. The market authorisation holder is Teva Respiratory LLC. 
     In an embodiment the medicament comprises an anti-CGRP antibody, which may be referred to as Fremanusumab. The anti-CGRP antibody may be produced by expression vectors having deposit numbers of ATCC PTA-6867 and ATCC PTA-6866 as disclosed in application WO2007054809. 
     As used herein, the term “contiguous” may refer to a close proximity, including within 1-2 mm or 1-4 mm or other amount, without actually touching. 
     As used herein, the term “channel” may include a cut-out or groove like portion of the packaging that provides a containing function in respect of the injection device. The channel may include a U-section, V-section or other suitably profiled section. The channel may extend around a portion of an accommodated injection device to cover the portion of said device. The channel may be arranged to abut and/or to be contiguous an accommodated injection device. The channel may substantially conform to the shape of the injection device. The channel may be formed with longitudinal walls adjoined by a base wall. A base wall of the channel can be distinguished from a longitudinal/lateral wall by a portion of the channel that comprises a directional vector of extension with a longitudinal/lateral component greater than a depth component. 
     As used herein, the term “recess” may include a cut-out or groove like portion of the packaging. In embodiments a handling recess may be arranged to provide user access, via one or more digits of a hand of a user, to a depth position of the channel to enable gripping of an injection device accommodated in the channel. The handling recess may be arranged adjacent to and extend orthogonal the channel (and therefore an accommodated injection device). In embodiments a positioning recess is arranged to receive a rib of the channel to locate the device in the channel. The recess may include a U-section, V-section or other suitably profiled section. The recess can be formed with longitudinal/lateral walls adjoined by an adjoining wall. An adjoining wall of the recess can herein be distinguished from a longitudinal/lateral wall by a portion of the recess that comprises a directional vector of extension with a lateral/longitudinal component greater than a depth component. 
     As used herein, the term “longitudinal” refers to a direction aligned to a length of the channel, and thus a longitudinal axis of an accommodated injection device. 
     As used herein, the term “lateral” refers to a direction aligned to a width of the channel, and thus a width of an accommodated injection device. The lateral direction is orthogonal to the longitudinal direction. 
     As used herein, the term “depth” refers to a direction aligned to a depth of the channel, and thus a depth of an accommodated injection device. The depth direction refers to the depth of the packaging when viewed from a packaging planform in a laterally and longitudinally extending plane. 
     In the accompanying figures the longitudinal, lateral and depth directions are designated by respective ‘L’, ‘W’ and ‘D’. 
     The term “above” with reference to the packaging refers to a position located above the planform when viewed in the depth direction. The term “below” with reference to the packaging refers to a position located below a base of the packaging when viewed in the opposed depth direction. The term “top” refers to a portion of the packaging that forms part of the planform when viewed from above. The term “bottom” refers to a portion of the packaging that abuts a support surface, such as a table, when the injection device is to be extracted from the channel. 
     The terms “proximal” and “distal” when used in reference to the injection device refer to a longitudinal position in respect of a delivery end of the device. When used in reference to the packaging they refer to a longitudinal position associated with the delivery end of an injection device accommodated in the channel. 
     The term “concave” when used in reference to the formation of the packaging may refer to a surface that is arranged to extend inwardly, including curved (e.g. a C-shape) and/or linear (e.g. a U-shape). The term “convex” when used in reference to the formation of the packaging may refer to a surface that is arranged to extend inwardly, including curved (e.g. a C-shape) and/or linear (e.g. a U-shape). 
     The present disclosure provides packaging suitable for a medical injection device, which includes suitability in that the packaging is dimensioned to accommodate a typical injection device, and thus includes suitability for injection training devices with dimensions corresponding to those of the associated injection device. Suitability for a medical injection device also includes that the packaging may be certified to various standards for leakage, ageing and porosity. Said standards may include the US Food and Drugs Association (FDA) Consensus Standards, as defined by the Institute of Packaging Professionals, Medical device Packaging Technical Committee, including D3078:1994; F1608:2000; and F1980:2002. 
     Referring to  FIG.  1    and  FIG.  2   , embodiment packaging  2  for an injection device  4  comprises a channel  6  that extends in the longitudinal direction L to accommodate the injection device. The channel  6  is formed by a first longitudinal wall  8  and a second longitudinal wall  10 , which are interposed by an adjoining base wall  12 . 
     A handling recess  14  enables handling of the injection device  4  accommodated in the channel  6 . The handling recess  14  extends in the lateral direction and is formed through the first longitudinal wall  8 . 
     A positioning rib  22  is arranged to protrude from the base wall  12  into the channel  6 . The positioning rib  22  is adapted to position the injection device  4  in the channel  6  via insertion into a complementary positioning recess  24  of the injection device  4 . 
     The positioning rib  22  is arranged offset laterally from the handling recess  14 . In respect of the positioning rib arranged offset laterally from the handling recess  14 , meant that the rib occupies a distinct lateral position from that of the handling recess, e.g. there is a portion of the base wall  12  of the channel  6  arranged therebetween. 
     The positioning rib  22  is arranged extending in a longitudinal field  15  defined by the handling recess  14 . By arranged within (or extending in) a longitudinal field it is meant that part or all of the positioning rib  22  occupies the same longitudinal position as the handling recess  14 . The handling recess  14  thus defines a longitudinal field/locus that is bounded/marked off by the longitudinal extremities of the handling recess. 
     The injection device  4  and channel  6  are complementary in shape such that the injection device  4  can be suitably accommodated in the channel  6 . 
     The injection device  4  includes a body  29 , which extends longitudinally between a distal end  30  and proximal end  32 , the proximal end  32  is adapted for delivery of the medicament. Said adaptation may comprises a subcutaneous delivery member (not shown) or a connector (an example includes a Luer connector) for receiving said member or other suitable configuration. Example of subcutaneous delivery members include a hypodermic needle. A removable end cap  35  may be arranged at the proximal end  32  to protect the subcutaneous delivery member. 
     The injection device  4  includes the positioning recess  24  arranged in the body  29  to extend in the longitudinal direction between the distal end  30  and proximal end  32 . The positioning recess  24  includes a first recess end  34  and a second recess end  36 . The positioning recess  24  is complementary in shape to the positioning rib  22 . The first recess end  34  and second recess end  36  are longitudinally disposed to receive in abutment and/or contiguously a corresponding first rib end  26  and second rib end  28  of the positioning rib  22 . 
     The positioning recess  24  includes first longitudinal wall  25 , a second longitudinal wall  27  adjoined by a base wall  29 . The first recess end  34  and a second recess end  36  comprise a respective distal lateral  31  and a proximal lateral wall  33  that adjoins the walls  25 ,  27  and  29 . The walls  25 ,  27 ,  29 ,  31  that form the sides and ends of the positioning rib are generally planar, although alternative configurations are included in the disclosure, including curved. The configuration of said walls of the positioning recess generally corresponds to those of the positioning rib  22  as will be discussed. 
     The positioning recess  24  includes a delivery window for visual feedback of medicament delivery. The delivery window is formed as at least part of a base wall  29  of the positioning recess  24 . 
     The injection device  4  includes a further positioning recess  38  corresponding to the positioning recess  24  (the disclosure also includes embodiments with a single such recess). The further positioning recess  38  is arranged on the body  29  longitudinally aligned and opposed to the positioning recess  24 . With one of the positioning recesses  24 ,  38  receiving the positioning rib  22  of the packaging  2 , the delivery window of the other positioning recess  24 ,  38  can be observed when viewing from the planform of the packaging  2 . A user may be notified of the operative state of the injection device before/whilst removing the injective device  4  from the packaging  2 . 
     The injection device  4  includes a label  52  arranged on the body  29 . The label  52  may include instructions for operation of the injection device (IFU) and/or a dosage regimen selected for the medicament. The label  52  is arranged relative to the or each positioning recess  24 ,  38  to be visible when viewing the planform of the packaging  2  accommodating the device  4 . For example, the label  52  is orientated equidistantly (or approximately equidistantly, which may include an offset of ±10 or 20%) about a longitudinal axis  11  that extends through a positioning recess  24 ,  38  or is otherwise suitably arranged. A user may thus be notified of the label before/whilst removing the injection device  4  from the packaging  2 . The label  52  is arranged at a different longitudinal position to the positioning recess  24 ,  38 . Since the positioning recess is aligned to the handling recess  14 , it is ensured that a user does not obscure the label when gripping an accommodated device  4 . The disclosure includes embodiments with alternatively arranged label. A label may refer to a portion of material adhered to the body, or otherwise attached thereto. A label may be formed in the body by printing, embossing, moulding, stamping or otherwise. 
     The handling recess  14  is arranged to ensure the proximal end  32  of the injection device  4  is not gripped during extraction. Gripping of the proximal end  32  may result in one or more of: damage to the user; damage to the subcutaneous delivery member; dislodging of the end cap. In other embodiments the handing recess  14  can be arranged to control gripping at any part of the injection device  4 . 
     In embodiments the injection device  4  may be replaced with a corresponding injection device training device, which can include the same components, geometric shape of the injection device and operability but without medicament delivery capability. Typically the device is dimensioned with a longitudinal length of 10-30 cm and a cross-sectional area of 0.8-20 cm 2 . 
     Referring to  FIG.  3    embodiment arrangements of the positioning rib with respect to the longitudinal field  15  include: the positioning rib  22   a  with both ends aligned to the periphery of the longitudinal field  15 ; the positioning rib  22   b ,  22   c  with one end aligned to the periphery of the longitudinal field  15  and the other arranged outside of the longitudinal field  15 ; the positioning rib  22   d  with both ends arranged outside of the longitudinal field  15  and the rib extending in the longitudinal field  15 ; the positioning rib  22   e ,  22   f  with both ends arranged outside of the longitudinal field  15  and the rib extending outside the longitudinal field  15 ; the positioning rib  22   g  with both ends aligned to the periphery of the longitudinal field  15  and formed of several protrusions; the positioning rib  22   h  with neither end aligned to the periphery of the longitudinal field  15  and arranged within of the longitudinal field  15 . It will be understood that in such embodiments the positioning recess  26  is correspondingly arranged to locate the ends of the injection device  4  in the desired position in the channel  6 . 
     With further reference to  FIGS.  1  and  2   , the handling recess  14  is formed by a first lateral wall  16  and a second lateral wall  18 , which are interposed by an adjoining wall  20 . The positioning rib  22  comprises a first rib end  26  a and second rib end  28  and extends laterally therebetween. 
     The first rib  26  end and second rib end  28  are aligned in the longitudinal direction to the respective first lateral wall  16  and second lateral  18  wall of the handling recess  14 . The positioning rib  22  is therefore arranged entirely within the longitudinal field  15  of the handling recess  14 . 
     In respect of the first rib end  26  and second rib end  28  arranged aligned longitudinally to the respective first lateral wall  16  and second lateral wall  18  of the handling recess  14 , it is to be understood that a portion that forms an end lateral wall of the rib, which may include a portion interconnecting the rib and base wall  12  of the channel  6  or a portion interconnecting the end lateral wall of the rib with a top adjoining wall of the rib (e.g. a round or chamfered or other like connection), overlaps a longitudinal position of part of the associated lateral wall  16 ,  18 . 
     In embodiments with an inclined first lateral wall  16  and/or an inclined second lateral wall  18  (an example of which is shown in the embodiment of  FIGS.  3 - 6   ) it is to be understood that the associated rib end can be longitudinally aligned to a longitudinal field  15  that spans the longitudinal distance of the incline. 
     In variant embodiments, one or both of the first rib end  26  and second rib end  28  are arranged outside of the longitudinal field  15  defined by the handling recess  14 . The positioning rib  22  thus has a greater longitudinal length than the longitudinal field  15  of the handling recess  14 . In an embodiment, one or both of the first rib end  26  and second rib end  28  are arranged within the longitudinal field  15  of the handling recess  14  and aligned to the adjoining wall  20  of the handling recess  14 . The positioning rib  22  thus has a lesser longitudinal length than the longitudinal field  15  of the handling recess  14 . 
     Referring to  FIGS.  4 - 13    an example comprises features within the scope of the preceding embodiments. The channel  6  includes the first longitudinal wall  8  and second longitudinal wall  10  arranged to extend along inclined planes that intersect at an apex arranged depth D below a base of the packaging  2 . The inclined planes are truncated by the adjoining base wall  12 . The inclination of the planes relative to the depth direction is 2-5°, however in other embodiments it may be 2-20° or other suitable amount. The adjoining base wall  12  is generally aligned in a plane extending in the longitudinal L and lateral W directions. Thus the channel  6  has a generally truncated V-shaped cross-section. The longitudinal walls  8 ,  10  and base wall  12  may adjoin along a straight edge or with a round, which may have a radius of 0.5-4 mm, or other profile including a chamfer. 
     In variant embodiments, which are not illustrated, the channel may have other suitable sections. One example is a U-shaped section, wherein first longitudinal wall and second longitudinal wall arranged aligned to each other and to the depth direction. Another example is a section which is profiled to conform to that of the injection device, e.g. a partially circular or curved cross section to conform to that of the embodiment injection device shown in  FIG.  1   . In such an example the section may follow that of the injection device such that it is either in abutment or continuous thereto. In other embodiments the aforedescribed channel sections may be combined. 
     Referring to  FIG.  6   , the first longitudinal wall  8  includes a first face  40 , which faces the channel  6 , and a second face  42 , which faces away from the channel  6 . The second longitudinal wall  10  includes a first face  44 , which faces the channel  6 , and a second face  46 , which faces away from the channel  6 . 
     A peripheral longitudinal wall  50  is arranged adjacent the first longitudinal wall  8 . The peripheral longitudinal wall  50  forms a peripheral wall of the packaging  2 . The peripheral longitudinal wall  50 , comprises a first face  54 , which faces away from channel  6 , and a second face  56 , which faces the channel  6 . The peripheral longitudinal wall  50  is inclined to the first longitudinal wall  8 , such that both walls extend along inclined planes that intersect at an apex arranged above the packaging  2 . The inclination of the planes relative to the depth direction may be 1-5° or other amount. The inclined planes are truncated by a top adjoining wall  64 , which adjoins the peripheral longitudinal wall  50  first longitudinal wall  8 . The inclination of the walls  8 ,  50  may aid in stacking, in the depth direction, of like packaging. 
     An additional first longitudinal wall  58  is arranged adjacent the second longitudinal wall  10 . The first longitudinal wall  58  forms an adjacent channel  48  for accommodating a further injection device. In the embodiment three such channels are provided. The first longitudinal wall  58 , comprises a first face  60 , which faces the channel  48 , and a second face  62 , which faces away from the channel  48 . The first longitudinal wall  58  is inclined to the second longitudinal wall  10 , such that both walls extend along inclined planes that intersect at an apex arranged above the packaging  2 . The inclination of the planes relative to the depth direction may be 1-5° or other amount. The inclined planes are truncated by a top adjoining wall  64 , which adjoins the first longitudinal wall  58  and second longitudinal wall  10 . The inclination of the walls  10 ,  58  may aid in stacking, in the depth direction, of like packaging. 
     The adjacent channel  48  and further channel and associated forming walls may comprise a similar configuration to that of the channel  8 , thus for brevity they are not described herein. For convenience the peripheral longitudinal wall  50  and first longitudinal wall  58  may be referred to generally as a further longitudinal wall when referring to the channel  8 . 
     In variant embodiments, which are not illustrated, there may be any suitable number of channels for accommodation of injection devices, including 1-6. The peripheral wall and/or first longitudinal wall adjacent the second longitudinal wall may be omitted, e.g. in an embodiment with only a single channel. In embodiments when present they may be alternatively arranged, including aligned in the depth direction. 
     Referring to  FIG.  5   , the first lateral wall  16  and the second lateral wall  18  of the handling recess  14  extend along inclined planes  19  that intersect at an apex  21 . The apex  21  is arranged below the packaging  2 , e.g. a base thereof. The extension of the lateral walls  16 ,  18  is truncated by the adjoining wall  20 . The inclination of the planes  19  relative to the depth direction may be 30-55° or other amount. The inclination of the lateral walls  16 ,  18  provides a wider mouth at a top of the handling recess  14 , which may aid a user when inserting a digit into said recess, e.g. by providing a shape that corresponds to the digit and/or by guiding the digit to a central location of the handling recess from which it is most appropriate to grip the injection device  4 . The inclination of the lateral walls  16 ,  18  (compared to lateral walls that extend from the same mouth separation and that are aligned in the depth direction) may provide a rigid region proximal the adjoining wall  20 . 
     The lateral walls  16 ,  18  adjoin the adjoining wall  20  with a round, which may have a radius of 5-20 cm or other amount. The round may provide a more rigid region proximal the adjoining wall  20  and may conform to a shape of a digit of a user. 
     The base wall  12  of the channel  6  has a greater depth than the adjoining wall  20  of the handling recess  14 . The base wall thus forms a reinforcing rib that extends in the longitudinal direction and protrudes in the opposed depth direction adjacent the channel  6 . Such an arrangement may provide a rigid region proximal the adjoining wall  20 , when compared to an embodiment (which is also included in the disclosure) wherein the base wall  12  of the channel  6  has the same depth as the adjoining wall  20  of the handling recess  14 . 
     In variant embodiments, which are not illustrated, the first and second lateral walls  16 ,  18  may be alternatively arranged, including aligned in the depth direction. The adjoining wall  20  may be alternatively arranged, including arranged at the same depth as and/or inclined to the base wall  12 . One or more of the adjoining wall  20 , first and second lateral walls  16 ,  18  may be alternatively profiled, including curved or stepped or straight edged. 
     Referring to  FIG.  3   , in an embodiment the adjoining wall  20  may include a reinforcing rib  23  protruding into the handling recess  14 . The reinforcing rib  23  may provide additional stiffening of the handling recess  14 . The reinforcing rib  23  extends longitudinally from the first and second lateral walls  16 ,  18 . The reinforcing rib  23  is laterally offset from the first longitudinal wall  8 . The offset may enable a user to more conveniently insert their digits into the handling recess  14  to grip the injection device  4 . The reinforcing rib  23  has a lateral width of less than between the first longitudinal wall  8  and second longitudinal wall  50 . In variant embodiments, which are not illustrated, the reinforcing rib may be alternatively arranged, including centrally aligned and extending from only one of the first and second lateral walls  16 ,  18 . 
     Referring to  FIG.  7   , the handling recess  14  is formed through the further longitudinal wall  50  (in addition to the previously discussed first longitudinal wall  8 ) the first and second lateral walls  16 ,  18  and adjoining wall  20  thus bridge said longitudinal walls. Such an arrangement may provide a handling recess  14  which has enhanced rigidity compared to an arrangement without said bridging. 
     The packaging includes a second handling recess  82 . The second handling recess  82  is formed through the first longitudinal wall  58  and second longitudinal wall  10 . The second handling recess  82  is complementary to the handling recess  14 , and is thus comprises like components, which for brevity are not described. The second handling recess  82  is longitudinally aligned to the handling recess  14 . The second handling recess  82  and first handling recess  14  may each be used by opposed digits of a user when gripping an injection device  4  accommodated in the channel  6  as will be discussed. The disclosure also includes handling recesses that are not complementary, including differing geometry and longitudinal alignment. 
     Referring to  FIGS.  3  and  6   , the first longitudinal wall  58  and second longitudinal wall  10  comprise respective opposed indentations  66 ,  68  adapted for gripping of the packaging  2 . Said adaption comprises a gripping wall  70  arranged with a local depth that extends in the global lateral W direction. The gripping walls  70  may be separated by 4-12 mm or other suitable distance. The gripping wall is dimensioned to fit a digit of a user, e.g. a length in the longitudinal direction L of 2-4 cm an adjoining semi-circular section arranged distal the top adjoining wall  64 . Such an arrangement provides a narrowing portion, which may be more convenient to grip then portions of the walls  10 ,  58  without the indentations, e.g. the narrowing portion enables a greater lateral force to be applied by opposed digits. The indentations extend in the global depth direction from the top adjoining wall  64 . Such an arrangement may reduce air locking of stacked packaging since the indentation provides a conduit for pressure relief that extends from the top adjoining wall  64  to a particular depth. 
     In a variant embodiment, which is not illustrated, the indentations may have other arrangements, including discrete from the adjoining wall  64  and/or with an alternatively profiled gripping wall. In embodiments packaging  2  comprising indentations  64 ,  66  that are formed without the previously described positioning rib  22  and/or handling recess  14 . 
     The indentations  66 ,  68  may aid in separating like packaging  2  stacked in the depth direction. The stack may be suppled in an open topped container wherein only the planform of the packaging is user accessible. 
     Referring to  FIG.  8   , the positioning rib  22  has a generally U-shaped cross-section. The lateral position of the rib is central in the channel  6 , although the disclosure also includes an eccentric lateral arrangement. The positioning rib  22  includes a first longitudinal wall  72  and a second longitudinal wall  74  interposed by an adjoining top wall  77 . The first longitudinal wall  72  and the second longitudinal wall  74  adjoin the base wall  12  of the channel  6 . 
     The first longitudinal wall  72  and a second longitudinal wall  74  are aligned in the depth direction D. In a variant embodiment, which is not illustrated, the first longitudinal wall and the second longitudinal wall of the positioning rib extend along inclined planes (e.g. with a 5-20° incline relative to the depth direction) that intersect at an apex truncated by the adjoining top wall. Such tapering of the positioning rib  22  may facilitate easier locating with the positioning recess  24  and subsequent insertion. The first longitudinal wall  72  and a second longitudinal wall  74  are generally planar, although alternative configurations are included in the disclosure, including curved. 
     A round adjoins the top wall  77  with the first longitudinal wall  72  and the second longitudinal wall  74 . The round may have a radius of 1-3 mm or other suitable amount. Compared to an embodiment (which is also included in the disclosure) with straight edged adjoining walls, embodiments with a round may reduce air locking when the positioning rib  22  is accommodated in the positioning recess  24  of the injection device  4 . The round may aid in guiding the rib into the recess during insertion of the injection device  4  into the channel  6 . In embodiments the edge is alternatively profiled, including chamfered. 
     A round adjoins the base wall  12  of the channel  6  and the positioning rib  22 . The round may have a radius of 1-3 mm or other suitable amount. The round may reduce air locking when the positioning rib  22  is accommodated in the positioning recess  24  of the injection device  4 . The round may increase flexural rigidity of the rib  22  compared to an embodiment (which is also included in the disclosure) with straight edged adjoining walls. In embodiments the edge is alternatively profiled, including chamfered. 
     Referring to  FIG.  4   , the positioning rib  22  includes, arranged at the respective first rib end  26  and second rib end  28  a proximal lateral wall  76  and a distal lateral wall  79 . The proximal lateral wall  76  and a distal lateral wall  79  may be similarly configured as for the adjacent first longitudinal wall  72  and a second longitudinal wall  74  in terms of orientation in the depth direction and connection with adjoining edges and optional taper. The proximal lateral wall  76  and distal lateral wall  79  are generally planar, although alternative configurations are included in the disclosure, including curved, including by a full round. 
     Referring to  FIG.  8   , the adjoining top wall  77  of the positioning rib  22  is generally planar in the lateral direction W. The base wall  29  of the positioning recess  24  is convex in the lateral direction W. The positioning recess  24  and positioning rib  22  are thus adapted to form a laterally extending concave shaped gap  9  between the top wall  77  of the positioning rib  22  and the base wall  29  of the positioning recess  24  when in an arrangement with the positioning recess  24  accommodating the positioning rib  22 . 
     Referring to  FIG.  9   , the adjoining top wall  77  of the positioning rib  22  is convex in the lateral direction W. The base wall  29  of the positioning recess  24  is convex in the lateral direction W. The positioning recess  24  and positioning rib  22  are thus adapted to form a laterally extending convex shaped gap  9  between the top wall  77  of the positioning rib  22  and the base wall  29  of the positioning recess  24  when in an arrangement with the positioning recess  24  accommodating the positioning rib  22 . 
     Referring to  FIG.  10   , the adjoining top wall  77  of the positioning rib  22  is generally planar in the lateral direction W. The base wall  29  of the positioning recess  24  is concave in the lateral direction W. The positioning recess  24  and positioning rib  22  are thus adapted to form a laterally extending convex shaped gap  9  between the top wall  77  of the positioning rib  22  and the base wall  29  of the positioning recess  24  when in an arrangement with the positioning recess  24  accommodating the positioning rib  22 . 
     Referring to  FIG.  11   , the adjoining top wall  77  of the positioning rib  22  is concave in the longitudinal direction L. The base wall  29  of the positioning recess  24  is generally planar in the lateral direction W. The positioning recess  24  and positioning rib  22  are thus adapted to form a longitudinally extending convex shaped gap  9  between the top wall  77  of the positioning rib  22  and the base wall  29  of the positioning recess  24  when in an arrangement with the positioning recess  24  accommodating the positioning rib  22 . 
     The embodiment of  FIG.  11    may be combined with any of those associated with  FIGS.  8 - 10   . In an embodiment, which is not illustrated, the longitudinally extending convex shape gap may be alternatively formed, including by a longitudinally concave base wall of the positioning recess and a generally planar adjoining top wall of the positioning rib or combinations thereof. 
     In the preceding embodiments, the lateral concavity may be formed with radii of 2-10 mm, or be alternatively curved, including with a maximum depth from the longitudinal walls  72 ,  74  of 0.25-2 mm or 0.5-1 mm or 5-20% of the width of the rib. In the preceding embodiments, the longitudinal concavity may be formed with radii of 0.1-0.5 m, or be alternatively curved, including with a maximum depth from the lateral walls  76 ,  79  of 0.5-3 mm or 0.5-2 mm or 5-20% of the length of the rib. The lateral/longitudinal convexity can be arranged with the equivalent dimensions as for the concavity, which for brevity is not repeated. In general the geometric extent of the concavity/convexity is selected to prevent the rib/recess flexing into each other. 
     As used herein the term “concave shaped gap” or “convex shaped gap” may refer to a shape of a gap between and formed one or both opposed surfaces of the positioning rib and position rib. The concave/convex shaped gap may extend in the lateral and/or longitudinal directions. 
     A convex shaped gap  9  may prevent/reduce a portion of the portioning rib  22  flexing into the base wall  29  of the positioning recess  24  of the injection device  4 , for instance when in use the top wall  77  of the positioning rib is subject to a compression load. Flexing of the top wall  77  into the base wall  29  may damage the injection device, particularly if the base wall  29  comprises the aforedescribed delivery window, e.g. by marking or otherwise obscuring the peripheral surface. 
     In the illustrated embodiments the first longitudinal wall  25  and second longitudinal wall  27  of the positioning recess  24  abut the corresponding first longitudinal wall  72  and second longitudinal wall  74  of the positioning rib  22 . It will be understood that portions of one or more of the side, end, top and base walls of the positioning rib/recess may be arranged contiguous and/or in abutment to provide the intended positioning of the injection device  4  in the packaging  2 . 
     Referring to  FIGS.  4  and  7   , the channel  6  includes closing portions comprising a laterally extending proximal end wall  78  and a laterally extending distal end wall  80 . The packaging  2  and injection device  4  including the respective positioning rib  22  and positioning recess  24  arranged to locate the injection device  4  in the channel  6  with the distal end  30  and proximal end  32  thereof apart from the respective distal end wall  80  proximal end wall  78 . Separating the ends of the injection device from the ends of the channel may reduce risk of damage of the injection device, e.g. a delicate end cap  35  of the proximal end  32  of the injection device  4  is maintained out of abutment with the packaging  2 , wherein abutment may effect transfer of load, in case of an impact, to dislodge the endcap. Dislodging of the end cap  35  may cause damage to the subcutaneous delivery member and/or could make the injection device dangerous to handle. 
     The separation between the proximal end  32  of the injection device  4  and proximal end wall  78  of the packaging  2  may be less than the longitudinal displacement to separate the end cap  35  from the proximal end  32 . Separation of the end cap  35  within the packaging  2  may thereby be prevented. 
     During insertion of the injection device  4  into the packaging  2 , the proximal end wall  78  and distal end wall  80  may provide a coarse alignment for the injection device  4  in the channel  6 , with fine alignment being subsequently provided by the engagement of the positioning rib  22  and positioning recess  24 . In an embodiment the aforedescribed tapering of the proximal end wall  78  and distal end wall  80  of the positioning rib  22  may transition during said insertion (via engagement with the positioning recess  24 ) the injection device  4  from abutment from one of the proximal or distal end wall  78 ,  80  to a positioning rib  22  controlled longitudinal location. 
     In variant embodiments, which are not illustrated, one or both of the proximal end wall  78  and distal end wall  80  may be omitted. 
     The positioning recess  24  is longitudinally offset with respect to the longitudinal axis of the injection device  4 . In a like manner, the positioning rib  22  is longitudinally with respect to the longitudinal axis of the channel  6  of the packaging  2 . With such a configuration (compared to the rib and recess being arranged longitudinally centred) the longitudinal orientation of the injection device  4  in the packaging can be controlled, e.g. with the proximal end  32  of the injection device  4  arranged at the intended proximal end of the packaging  2 . The arrangement may be further controlled by the inclusion of the proximal end wall  78  and the distal end wall  80  of the channel  2 , which can be disposed to block accommodation of the positioning rib  22  in the positioning recess  24  when the proximal end  32  of the injection device  4  is arranged proximal the distal end of the packaging (or the converse). It is to be understood that the disclosure also includes centrally aligned positioning ribs and/or recesses. 
     The positioning rib  22  and positioning recess  24  can be transitioned between a separated position and an accommodated position (as shown in  FIGS.  9  and  10   ), in which the positioning rib  22  is accommodated in the positioning recess  24  to position the injection device  4  in the channel  6 . 
     In the accommodated position the positioning recess  24  stiffens the packaging  2 . Since the geometry of the positioning recess  24  corresponds to the positioning rib  22 , the positioning recess  24  can restrain displacement of portions of the accommodated positioning rib  22 , said portion can include one or more of the rib: proximal lateral wall  76 ; distal lateral wall  79 ; first longitudinal wall  72 ; second longitudinal wall  74 ; adjoining top wall  77  (generally in embodiments which do not comprise a adjoining top wall  77 ). 
     In the accommodated position the positioning rib  22  and positioning recess  24  may be adapted with various fits. In an embodiment said fit includes a locating fit that does not require an insertion and/or extraction force to transition to/from the accommodated position. Such a fit can be achieved by arranging the positioning rib  22  and positioning recess  24  to have entirely corresponding dimensions and/or the positioning recess  24  to have corresponding dimensions that are greater than those of the positioning rib  22  (or the positioning rib  22  to have corresponding dimensions that are less than those of the positioning rib  24 ). 
     In an embodiment said fit includes a force-fit that implements an insertion and/or extraction force to transition to/from the accommodated position. Such a fit can be achieved by arranging the positioning rib  22  to be in an at least partially compressed state when arranged in the accommodated position. The compressed state can be achieved by dimensioning the positioning recess  24  to be smaller than the positioning rib  22 , which may include forming part or all of the longitudinal length and/or lateral width of the positioning recess  24  to be less (e.g. by 1-5%) than the corresponding dimension of the positioning rib  22 . The compressed state can be achieved by forming the positioning rib  22  to be displaceable in the accommodated position, including via elastic and/or plastic material deformation. 
     In like embodiments the force-fit is achieved by arranging the positioning recess  24  to be in an at least partially expanded state when arranged in the accommodated position, which in further embodiments may be combined with the positioning rib  22  in the compressed state. 
     In embodiments a force-fit is achieved by arranging the positioning rib  22  and positioning recess  24  to have entirely corresponding dimensions whereby a material friction coefficient provides the extraction/insertion force. 
     In an embodiment the force-fit includes an extraction force, to transition from the accommodated position to the separated position, less than a weight of the packaging  2 . In an embodiment the mass of the packaging may be 100 grams, wherein the extraction force is less than 1 Newton. It will be understood that the force may vary depending on the configuration (and thus the mass) of the packaging  2 , e.g. it can be less than 0.5, 1.5 or 2 Newton. With such an arrangement the packaging  2  may remain in abutment with an abutment surface (e.g. a table) when the device  4  is extracted from the channel  6 , and thus the positioning rib  22  retracted from the positioning recess  24 . 
     In embodiments: the positioning rib  22  has a nominal longitudinal length of up to 1.5 or 1 or 0.5% less than that of that of the positioning recess  24 ; the positioning rib  22  has a nominal lateral width of up to 4 or 6 or 8% less than that of that of the positioning recess  24 . 
     In embodiments: the positioning rib  22  has a nominal longitudinal length of 38.6 mm and a nominal lateral width of 5.2 mm; and the positioning recess  24  has a nominal longitudinal length of 38.8 mm and a nominal lateral width of 5.4 mm. In embodiments each of the described dimensions may be may be ±1% or 5% or 10%. The total distance between the positioning rib  22  and positioning recess  24  in the lateral and longitudinal direction may be 0.2 mm±1% or 5% or 10%. 
     In embodiments the positioning rib  22  is operatively arranged for stiffening of the handling recess  14 , e.g. the positioning rib  22  increases the resistance of the packaging to bending moment applied about a laterally extending axis. The handling recess  14  may be stiffened in terms of a flexural rigidity extending longitudinally along said recess. The positioning rib  22  thus compensates for the loss of stiffness due to the formation of the handling recess  14  through the associated walls. Suitable arrangements of the positioning rib  22  may include the geometric configuration of the rib (e.g. one or more of the length, depth, width) specifically selected for stiffening. Said arraignment may include the positioning of the rib (e.g. aligned to the handling recess  14 ). 
     In embodiments the positioning rib  22  has a depth ‘d’ of about 25% or 20-30% of a depth of the recess  14  (i.e. the nominal depth of the adjoining wall  20  from the top adjoining wall  64  of the handling recess  14 ). In embodiments the positioning rib  22  has a longitudinal length ‘l’ about 24% or 20-30% or 15-35% of a longitudinal length of the channel  6 . In embodiments the positioning rib  22  has a lateral width ‘w’ of about 3% or 2-4% of a longitudinal length of the channel  6 . In embodiments the positioning rib  22  has a lateral width of about 20% or 15-25% of a lateral width of the channel  6 . In embodiments j is about 8% or 6-10% or 4-15% or 2-20% of the product of w and d 3 . 
     Referring to  FIGS.  4 ,  7  and  12    the channel  6  includes laterally extending abutment ribs  84 ,  85 . The abutment ribs  84 ,  85  are arranged to abut the injection device  4  accommodated in the channel  6 . The abutment ribs  84 ,  85  include curved protrusions that protrude into the channel  6 . The abutment ribs  84 ,  85  may stiffen sections of the channel. The abutment ribs  84  are arranged within the longitudinal field  15  of the lateral walls  16 ,  18  of the handling recess  14 . The abutment rib  85  is arranged at the distal end of the channel  6 . The abutment ribs  84 ,  85  are formed of a single protrusion. 
     The abutment ribs  84 ,  85  may prevent/reduce lateral movement of the injection device  4  accommodated in the channel  6 . The abutment ribs  84 ,  85  may control portions of the body  29  of the device  4  abutted by the packaging. The portion abutted may receive wear due to friction, thus the abutment ribs  84 ,  85  may localise such wear. In an example, the wear may be directed away from the label  52  so as to avoid obscuring instructions thereof. 
     In variant embodiments, which are not illustrated, the abutment ribs may be alternatively arranged, e.g. the abutment ribs may be protrude with other suitable shapes including V-shaped or Square-shaped. The abutment ribs may be formed of multiple adjacent protrusions. The abutment ribs may be alternatively located, including at the proximal end of the channel. 
     Referring to  FIGS.  12  and  13   , the channel  6  includes longitudinally extending cut-outs  86  arranged adjacent each longitudinal wall  72 ,  74  of the positioning rib  22 . The cut-outs  86  project as cavities from the base  12  of the channel in the depth direction D, hence in the opposed direction to the positioning rib  22 . The cut-outs  86  may enhance stiffness proximal the handling recess  14 . The cut-outs  86  may facilitate more convenient gripping of an injection device  4  accommodated in the channel  6  by enabling a user to partially insert their digits into the cut-outs when gripping the device  4 . 
     Referring to  FIG.  14   , the cut-outs  86  may protrude to abut the body  29  of an injection device  4  accommodated in adjacent like packaging  3 , which is stacked in the depth direction beneath the packaging  2 . The cut-outs  86  may restrain the abutted injection device  4 . 
     Referring to  FIGS.  14 - 17   , the packaging may be adapted to provide various stacking configurations. Referring to  FIG.  17   , the packaging  2  is adapted to enable insertion into corresponding adjacent packaging  3 . The insertion is to a first depth with the packaging  2 ,  3  both correspondingly arranged in a first position. The first depth comprises a substantial portion (e.g. at least 60-90%) of the depth of the packaging such that packaging without an injection device accommodated therein can be conveniently stacked and stowed. 
     The adaptation may comprise a general correspondence of adjacent portions of the packaging  2 ,  3  including by tapering and rounding as discussed previously. Referring to  FIG.  17   , the adaptation includes grooves  88  arranged through an exterior face of a distal  90  and proximal  92  peripheral lateral wall. Adjoining walls  94  adjoin the proximal peripheral lateral wall  92  and proximal end wall  78  of the channel  6 , and the distal peripheral lateral wall  90  and distal end wall  80  of the channel  6 . The grooves  88  form corresponding protrusions  96  on opposed interior faces of the peripheral lateral walls  90 ,  92 . A protrusion  96  of the packaging  2  is insertable into the groove  88  of packaging  3  for said stacking. 
     The grooves  88  extend in the depth direction to proximal a base of the peripheral walls  90 ,  92 . The grooves have a generally curved cross section, which may aid insertion of a corresponding protrusion. 
     Referring to  FIGS.  15  and  16   , the packaging  2  is adapted to enable insertion into corresponding adjacent packaging  3  to a second depth, which is less that the first depth, with the packaging  2 ,  3  arranged in a second position. In the second position the packaging  3  is rotated about the depth axis by 180° relative the packaging  2 . In this position a base  98  of the groove  88  of packaging  2  abuts the adjoining walls  94  of packaging  3  to provide a stable abutment. The abutment may prevent excessive contact between an injection device  4  arranged in the packaging  3  and the stacked packaging  2 . 
     The abutment of the base  98  of the groove  88  of packaging  2  with the adjoining wall  94  of packaging  3  with the packaging  2 ,  3  arranged in the second position and the insertion of the protrusion  96  of packaging  2  in to groove  88  of packaging  3  with the packaging  2 ,  3  arranged in the first position can be achieved by eccentrically arranging the grooves  88  with respect to width. In the illustrated embodiment the eccentric arrangement comprises the groove  88  arranged proximal an end channel  6 , rather than at the centre along the peripheral wall. 
     In embodiments, which are not illustrated, the grooves may be alternatively and/or additionally arranged, e.g. including though the peripheral longitudinal wall  50  or the channel  6 . Reference to grooves can include formation on the interior or exterior face of a peripheral wall, or other wall. The grooves may be alternatively shaped, e.g. including a linear rather that curved cross section. 
     In variant embodiments, the positioning rib  22  may be formed of more than one protrusion. An example includes a separate first protrusion and second protrusion arranged at the respective first rib end  26  and at the second rib end  28 . Reference to a positioning rib herein may therefore refer to a rib formed of one or a plurality of separated protrusions. 
     The packaging may be formed by thermoforming, vacuum forming, casting or other forming process known to the skilled person. Typically the single plastic sheet in planar form is thermoformed to the desired profile via a mould and other associated equipment known to the skilled person. Suitable materials for the plastic sheet include polystyrene. Suitable gauges for the plastic sheet prior to forming include 0.6 mm. 
     An embodiment method of stowing embodiment injection device  4  (or a like configured injection device training device) in packaging  2  as disclosed herein may include arranging said the injection device  4  in an aligned position with the first recess end  34  and the second end  36  of the positioning recess  24  and/or  38  thereof longitudinally aligned with the respective first lateral wall  16  and the second lateral wall  18  handling recess  14 . The user may displace the injection device  4  arranged in said aligned position in the depth direction to insert it into the channel  6 , which may include the positioning rib  22  and positioning recess  24  or  38  arranged in the accommodated position. 
     Referring to an embodiment comprising: a second positioning recess  38  arranged opposed and longitudinally aligned to the positioning recess  24 ; and the associated first rib  26  ends and second rib ends  28  arranged aligned in the longitudinal direction to the respective first lateral wall  16  and second lateral  18  wall of the handling recess  14 . A user may in the aligned position align the first rib  26  end and second rib end  28  of the positioning recess  38 , with said recess  38  arranged visible from above the packaging, with the first lateral wall  16  and second lateral  18  wall of the recess  14 , which therefore ensures longitudinal alignment of the positioning rib  22  and positioning recess  24 . Thus the arrangement of the positioning recess  38  and handling recess  14  may be used as a longitudinal guide during insertion. 
     In an embodiment method of extracting an injection device  4  (or a like configured injection device training device) stowed in packaging  2  as disclosed herein may include inserting a digit (not shown) of a user into the handling recess  14 . The insertion may include movement of said digit in the depth and/or lateral direction. The method may include gripping said device and extracting it from the channel  6 . Extracting the device  4  from the channel  6  may include transitioning the positioning rib  22  and positioning recess  24  from the accommodated position to the separated position, including by displacement of the injection device in the opposed depth direction. Gripping the device  4  may include the application of a force in the lateral direction to the device by said digit arranged in the handling recess  14 . In embodiments comprising the handling recess  14  and a complementary second handling recess  82 , gripping the device  4  may include the application of opposed lateral force by opposed digits, each arranged in one of the recesses  14 ,  82 . 
     From the described embodiments it will be understood that the packaging  2  may enable convenient extraction of the injection device  4 . The handling recess  14  conveniently enables a user to accesses the channel  6  for gripping, by opposed digits, of the accommodated injection device  4 . The injection device may by extracted without complex movements, such as rotation of the device and/or a hand of the user. It will thus be understood that the packaging is suited for use by users with a disorder that effects dexterity. Thus the injection device  4  preferably includes a medicament for treatment or prevention of such an illness. 
     To close the channel  6 ,  48  of the packaging  2  and/or secure the injection device  4  therein various arraignments (not shown) may be provided, which may be referred to as a lid. 
     In an embodiment a tear away or break through lid may be provided as medical blister type packaging. A lidding film may provide a peel-open feature that can be peeled open using two-hands, including by a knuckle-roll-peel technique. The lidding film can be made from plastic, aluminium, medical grade papers, or other suitable material. A lidding film of a blister pack may be permeable to gas porous to allow sterilization but not permeable to microorganisms. A presently available example plastic material is Tyvek® by DuPoint™. The lidding film may be made from a completely non-permeable or non-breathable film. In instances where a non-breathable film is used, sterilization can be via an electron beam or similar. 
     In an embodiment, the lid may comprise a thick plastic sheet, which may correspond to that forming the channel  6 ,  48 , thus providing a medical tray or medical clamshell type packaging. 
     Embodiments are also provided according to the following clauses: 
     Clause 1. Packaging  2  for an injection device  4 , the packaging may include a channel  6  extending longitudinally to accommodate the injection device, the channel including a longitudinal wall  8  adjoining a base wall  12 ; a handling recess  14  extending laterally and formed through the longitudinal wall  8 , a positioning rib  22  extending longitudinally and protruding from the base wall into or away from the channel for insertion into a positioning recess  24  of the injection device, the positioning rib arranged offset laterally from the recess. The positioning rib may and extend in and/or outside of a longitudinal field  15  defined by the handling recess. 
     Clause 2. The packaging of clause 1 or another embodiment disclosed herein, wherein the handling recess  14  including a first lateral wall  16  and a second lateral wall  18  interposed by an adjoining wall  20 . The positioning rib  22  may include a first rib end  26  a and second rib end  28 . The first rib end may be arranged: aligned longitudinally to the first lateral wall; arranged outside of the longitudinal field  15  defined by the handling recess; arranged within of the longitudinal field  15  defined by the handling recess. The second rib end may be arranged: aligned longitudinally to the second lateral wall; arranged outside of the longitudinal field  15  defined by the handling recess; arranged within of the longitudinal field  15  defined by the handling recess. Any combination of the preceding first and second rib end arrangements is included within the disclosure. The entire rib may extend outside of or within the longitudinal field  15  defined by the handling recess. 
     Clause 3. The packaging of either of clauses 1 or 2 or another embodiment disclosed herein, wherein the positioning rib  22  is formed as a single protrusion. 
     Clause 4. The packaging of any of clauses 2-3 or another embodiment disclosed herein, wherein the first lateral wall  16  and the second lateral wall  18  of the handling recess  14  extend along inclined planes  19  that intersect at an apex  21  and are truncated by the by the adjoining wall  20 . 
     Clause 5. The packaging of any preceding clause or another embodiment disclosed herein, wherein the positioning rib  22  has a lateral width ‘w’ a depth ‘d’ and the handling recess has a depth ‘j’, wherein j is 4-15% of the product of w and d 3 . 
     Clause 6. The packaging of any preceding clause or another embodiment disclosed herein, wherein the positioning rib  22  includes a first longitudinal wall  72  and a second longitudinal wall  74  interposed by an adjoining top wall  77 , the first longitudinal wall  72  and the second longitudinal wall  74  adjoining the base wall  12  of the channel  2 . 
     Clause 7. The packaging of clause 6 or another embodiment disclosed herein, wherein a top wall  77  of the positioning rib  22  is concave in the lateral direction. 
     Clause 8. The packaging of either clause 6 or clause 7 or another embodiment disclosed herein, wherein a round adjoins the adjoining top wall ( 77 ) with the first longitudinal wall ( 72 ) and the second longitudinal wall ( 74 ). 
     Clause 9. The packaging of any of clauses 6-8 or another embodiment disclosed herein, wherein a round adjoins the base wall  12  of the channel  6  and the positioning rib  22 . 
     Clause 10. The packaging of any preceding clause or another embodiment disclosed herein, wherein the positioning rib  22  is dimensioned with: a longitudinal length of 38.6 mm and a lateral width of 5.2 mm±5, or 10% or 20%. 
     Clause 11. The packaging of clause 2 or another embodiment disclosed herein, wherein the base wall  12  of the channel  6  is arranged with a greater depth than the adjoining wall  20  of the handling recess  14 . 
     Clause 12. The packaging of any preceding clause or another embodiment disclosed herein, wherein a further longitudinal wall  50  extends contiguous the longitudinal wall  8  of the channel  12 , the handling recess  14  formed through the further longitudinal wall  50 . 
     Clause 13. The packaging of clause 12 or another embodiment disclosed herein, wherein the further longitudinal wall  50  and longitudinal wall  8 , comprise opposed indentations  66 ,  68  adapted for gripping of the packaging, the indentations extending in a depth direction from a top adjoining wall  64 , that interposes and adjoins the further longitudinal wall  50  and longitudinal wall  8 . 
     Clause 14. The packaging of any preceding clause or another embodiment disclosed herein, wherein a top wall  77  of the positioning rib  22  is concave shaped and/or another shape suitable for preventing the top wall flexing into an adjacent surface of the positioning recess of the injection device. The concave shape may extend in the lateral and/or longitudinal direction. The concave shape may extend generally between outer walls (e.g. lateral or longitudinal wall that defines the rib). The concave shape may be generally curved and/or partially linear. 
     Clause 15. The packaging of any preceding clause or another embodiment disclosed herein, wherein the base wall of the channel includes longitudinally extending cut-outs  86  arranged on one or both sides of the positioning rib  22 . The cut-outs may protrude in an opposed direction to the positioning rib  22 . 
     Clause 16. The packaging of any preceding clause or another embodiment disclosed herein, wherein the channel  6  includes laterally extending abutment ribs  84 . The abutment ribs may be arranged proximal the ends of the positioning rib  22 . 
     Clause 17. Packaging  2  for an injection device  4 , the packaging may include the packaging of any preceding clause or another embodiment disclosed herein. The packaging may include: a channel  6  extending longitudinally to accommodate the injection device, the channel including a longitudinal wall  8  adjoining a base wall  12 ; a handling recess  14  extending laterally and formed through the longitudinal wall  8 , a positioning rib  22  extending longitudinally and protruding from the base wall into the channel for insertion into a positioning recess  24  of the injection device, the positioning rib arranged offset laterally from the handling recess and arranged longitudinally in the channel to stiffen the handling recess, including a flexural rigidity longitudinally along the handling recess. 
     Clause 18. Packaging  2  for an injection device  4 . The packaging may include the packaging of any preceding clause or another embodiment disclosed herein. The packaging comprising: a channel  6  extending longitudinally to accommodate the injection device, the channel including a longitudinal wall  8  adjoining a base wall  12 ; a positioning rib  22  extending longitudinally and protruding from the base wall into the channel for insertion into a positioning recess  24  of the injection device, wherein a top wall  77  of the positioning rib  22  is concave shaped. 
     Clause 19. A system comprising the packaging  2  of any preceding clause or another embodiment disclosed herein, and an injection device  4 , or injection device training device, for accommodating in the channel  6  of the packaging, wherein said device comprises a positioning recess  24  to accommodate the positioning rib  22 . 
     Clause 20. The system of clause 19 or another embodiment disclosed herein, wherein, with the positioning recess  24  accommodating the positioning rib  22 , the positioning recess  24  of the device  4  and the adjoining top wall  77  of the positioning rib  22  are adapted to form a convex shaped gap between the adjoining top wall of the positioning rib and an opposed surface  29  of the positioning recess  24 . The convex shaped gap may be in the lateral or longitudinal direction. 
     Clause 21. The system of either clause 19 or clause 20 or another embodiment disclosed herein, wherein the positioning recess  24  of the device  4  and positioning rib  22  of the packaging  2  are arranged to locate the device in the channel  6  with: a distal end  30  of the device arranged apart from a distal end wall  80  of the channel  6 ; and/or a proximal end  32  of the device arranged apart from a proximal end wall  78  of the channel  6 . 
     Clause 22. The system of any of clauses 19-20 or another embodiment disclosed herein, wherein the positioning recess  24  of the device  4  are arranged to prevent accommodation of the injection device  4  in the channel  6  with: a distal end  30  of the device arranged proximal the proximal end wall  78  of the channel  6 ; and/or a proximal end  32  of the device arranged proximal the distal end wall  80  of the channel  6 . 
     Clause 23. The system of any of clauses 19-21 or another embodiment disclosed herein, wherein the positioning recess  24  of the device  4  is arranged to be contiguous and/or in abutment with an accommodated positioning rib  24  of the packaging  2 . 
     Clause 24. The system of any of clauses 19-23 or another embodiment disclosed herein, wherein the device  4  comprises a further positioning recess  38  arranged longitudinally aligned and opposed positioning recess  24 . 
     Clause 25. The system of any of clauses 19-24 or another embodiment disclosed herein, wherein injection device  4  comprises a label  52 , the positioning rib  22 , positioning recess  24  and label  52  arranged with the label visible from a planform of the packaging (e.g. when viewed in the depth direction from above the packaging), with the positioning rib  22  accommodated in the positioning recess  24  (e.g. with the injection device accommodated in the channel). 
     Clause 26. The system of any of clauses 19-25 or another embodiment disclosed herein, wherein injection device  4  comprises a label  52 , wherein the label  52  is longitudinally offset from the positioning rib  22 . 
     Clause 27. The system of any of clauses 19-26 or another embodiment disclosed herein, wherein the positioning rib  22  and positioning recess  24  are adapted with a force-fit connection, wherein the force-fit connection includes an extraction force less than a weight of the packaging  2 . 
     Clause 28. A pre-packaged injection device  4 , or injection device training device, arranged with a positioning recess  24  thereof accommodating a positioning rib  22  of the packaging  2  of any of clauses 1-25 or another embodiment disclosed herein. 
     Clause 29. The system of any of clauses 19-27 or the pre-packaged injection device of clause 26 or another embodiment disclosed herein, wherein the injection device comprises a medicament as disclosed herein. 
     Clause 30. The system of any of clauses 19-27 or 29 or the pre-packaged injection device clause 26 or another embodiment disclosed herein, wherein the injection device is for use in the treatment or prevention of a disorder as disclosed herein. 
     Clause 31. Use of the packaging  2  of any of clauses 1-19 or another embodiment disclosed herein, for accommodating an injection device or an injection device training device. 
     Clause 32. Use of an injection device  4  for accommodating and restraining the positioning rib  22  of the packaging  2  of any of clauses 1-19 or another embodiment disclosed herein. 
     Clause 33. The injection device of any preceding clause including a medicament as disclosed herein. 
     Clause 34. An injection device comprising a positioning recess  24  adapted to accommodate the positioning rib  22  of the packaging  2  of any of clauses 1-19 or another embodiment disclosed herein. The injection device may include a medicament as disclosed herein, e.g. arranged in a container thereof. 
     Clause 33. A method of stowing an injection device  4  or injection device training device, in packaging  2 . The packaging may be according to any of clauses 1-32 or another embodiment as disclosed herein, the method may include arranging said device with a positioning recess  24 ,  38  thereof arranged within a longitudinal field  15  defined by a handling recess  14  of the packaging  2 , the handling recess  14  extending laterally an arranged through a longitudinal wall  6 , the longitudinal wall  6  forming a longitudinally extending channel  4  to accommodate the injection device, inserting the aligned device into the channel. 
     Clause 34. The method of clause 34 or another embodiment disclosed herein, including inserting a positioning rib  22  of the channel  6  of the packaging  2  into a positioning recess  24  of the device, the positioning rib arranged within a longitudinal field of the handling channel  14 . 
     Clause 35. A method of stiffening injection device packaging  2 . The packaging may be according to any of clauses 1-34 or another embodiment as disclosed herein, the method may include accommodating a positioning rib  22  of packaging within a positioning recess  24  of an injection device  4 , wherein the positioning recess cooperates with the positioning rib to support the positioning rib, the positioning rib arranged longitudinally in a channel  6  to accommodate the injection device, the positioning rib to increase a flexural rigidity longitudinally along a laterally extending handling recess. 
     Clause 36. A method of extracting an injection device  4 , or injection device training device, stowed in packaging  2 . The packaging may be according to any of clauses 1-34 or another embodiment as disclosed herein, the method may include inserting a digit of a user into a laterally extending handling recess  8 , the recess arranged through a longitudinal wall  8 , the longitudinal wall  8  forming a longitudinally extending channel  6  to accommodate said device, the channel comprising a longitudinally extending rib  22  operatively arranged to stiffen the handling recess. The method may include gripping said device with the digit and extracting it from the channel. 
     Clause 37. Packaging  2  for an injection device  4 , the packaging may include the packaging of any preceding clause or another embodiment disclosed herein. The packaging may be arranged to be insertable into corresponding packaging to a first depth, wherein the packaging and corresponding packaging have a first orientation, which comprises corresponding orientation. The first orientation may include the corresponding packaging with a distal end thereof arranged proximal a distal end of the packaging. The packaging may be arranged to be insertable into corresponding packaging to a second depth, wherein the packaging and corresponding packaging have an alternative second orientation. The second orientation may include the corresponding packaging with a distal end thereof arranged proximal a proximal end of the packaging. The packaging may include a groove  88  forming a corresponding protrusion  96  for insertion into a corresponding groove  88  of the corresponding packaging. The protrusion  96  of the packaging may be insertable in to the groove of the corresponding packaging in the first orientation. In the second orientation, a base  98  of the groove  88  of the packaging may abut a wall  94  of the corresponding packaging to restrict insertion to the second depth. In the first orientation the base  98  of the groove  88  of the packaging may restrict insertion depth. 
     In the claims, any reference signs placed between parentheses shall not be construed as limiting the claim. The word ‘comprising’ does not exclude the presence of other elements or steps then those listed in a claim. Furthermore, the terms “a” or “an,” as used herein, are defined as one or more than one. Also, the use of introductory phrases such as “at least one” and “one or more” in the claims should not be construed to imply that the introduction of another claim element by the indefinite articles “a” or “an” limits any particular claim containing such introduced claim element to inventions containing only one such element, even when the same claim includes the introductory phrases “one or more” or “at least one” and indefinite articles such as “a” or “an.” The same holds true for the use of definite articles. Unless stated otherwise, terms such as “first” and “second” are used to arbitrarily distinguish between the elements such terms describe. Thus, these terms are not necessarily intended to indicate temporal or other prioritization of such elements. The mere fact that certain measures are recited in mutually different claims does not indicate that a combination of these measures cannot be used to advantage. 
     Unless otherwise explicitly stated as incompatible, or the physics or otherwise of the embodiments, example or claims prevent such a combination, the features of the foregoing embodiments and examples, and of the following claims may be integrated together in any suitable arrangement, especially ones where there is a beneficial effect in doing so. This is not limited to only any specified benefit, and instead may arise from an “ex post facto” benefit. This is to say that the combination of features is not limited by the described forms, particularly the form (e.g. numbering) of the example(s), embodiment(s), or dependency of the claim(s). Moreover, this also applies to the phrase “in one embodiment”, “according to an embodiment” and the like, which are merely a stylistic form of wording and are not to be construed as limiting the following features to a separate embodiment to all other instances of the same or similar wording. This is to say, a reference to ‘an’, ‘one’ or ‘some’ embodiment(s) may be a reference to any one or more, and/or all embodiments, or combination(s) thereof, disclosed. Also, similarly, the reference to “the” embodiment may not be limited to the immediately preceding embodiment. 
     Unless otherwise stated, an object which is said to extend in a particular direction is to be construed as having a component of a directional vector that extends in said direction and does on preclude the extension in alternative directions. 
     The foregoing description of one or more implementations provides illustration and description, but is not intended to be exhaustive or to limit the scope of the invention to the precise form disclosed. Modifications and variations are possible in light of the above teachings or may be acquired from practice of various implementations of the present disclosure. 
     LIST OF REFERENCES 
     
       
         
           
               
               
             
               
                   
                   
               
             
            
               
                   
                 2 Packaging 
               
               
                   
                   6, 48 Channel 
               
               
                   
                     8, 58 First longitudinal wall 
               
               
                   
                       40, 60 First face 
               
               
                   
                       42, 62 Second face 
               
               
                   
                       66 Indentation 
               
               
                   
                         70 Gripping wall 
               
               
                   
                     10 Second longitudinal wall 
               
               
                   
                       44 First face 
               
               
                   
                       46 Second face 
               
               
                   
                       68 Indentation 
               
               
                   
                         70 Gripping wall 
               
               
                   
                     50 Peripheral longitudinal wall 
               
               
                   
                       54 First face 
               
               
                   
                       56 Second face 
               
               
                   
                     64 Top adjoining wall 
               
               
                   
                     12 Base wall 
               
               
                   
                     22 Positioning rib 
               
               
                   
                       26 First rib end 
               
               
                   
                         76 Proximal lateral wall 
               
               
                   
                       28 Second rib end 
               
               
                   
                         79 Distal lateral wall 
               
               
                   
                       72 First longitudinal wall 
               
               
                   
                       74 Second longitudinal wall 
               
               
                   
                       77 Adjoining top wall 
               
               
                   
                     78 Proximal end wall 
               
               
                   
                     80 Distal end wall 
               
               
                   
                   14, 82 Handling recess 
               
               
                   
                     15 Longitudinal field 
               
               
                   
                     16 First lateral wall 
               
               
                   
                     18 Second lateral wall 
               
               
                   
                     20 Adjoining wall 
               
               
                   
                       23 Reinforcing rib 
               
               
                   
                 4 Injection device 
               
               
                   
                   29 Body 
               
               
                   
                     24, 38 Positioning recess 
               
               
                   
                       25 First longitudinal wall 
               
               
                   
                       27 Second longitudinal wall 
               
               
                   
                       29 Base wall 
               
               
                   
                       34 First recess end 
               
               
                   
                         31 Proximal lateral wall 
               
               
                   
                       36 Second recess end 
               
               
                   
                         33 Distal lateral wall 
               
               
                   
                       52 label 
               
               
                   
                   30 Distal end 
               
               
                   
                   32 Proximal end 
               
               
                   
                     35 End cap 
               
               
                   
                   11 Longitudinal axis