Patent Publication Number: US-2020275834-A1

Title: Ophthalmologic information processing apparatus, ophthalmologic system, ophthalmologic information processing method, and recording medium

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     The present application is a continuation application of International Patent Application No. PCT/JP2018/038121, filed Oct. 12, 2018, which claims priority to Japanese Patent Application No. 2017-225888, filed Nov. 24, 2017. The contents of these applications are incorporated herein by reference in their entirety. 
    
    
     FIELD 
     The disclosure relates to an ophthalmologic information processing apparatus, an ophthalmologic system, an ophthalmologic information processing method, and a recording medium. 
     BACKGROUND 
     Age-related macular degeneration (AMD) is one of the causative diseases of visual disturbance. AMD is a disease in which a macular region is impaired directly or indirectly by aging. AMD is classified into exudative age-related macular degeneration (exudative AMD) and atrophic age-related macular degeneration (atrophic AMD). Exudative AMD is a disease in which a retina is damaged by invasion of choroidal neovascularization from the choroid to the lower layer of retinal pigment epithelium layer (hereinafter, RPE) or invasion of choroidal neovascularization between the retina and the RPE. Atrophic AMD is a disease in which the retina is damaged by gradual atrophy of the RPE and vision is gradually decreased. 
     Photo dynamic therapy (PDT), drug therapy, laser coagulation and the like are known as effective treatments of exudative AMD. On the other hand, effective treatment for atrophic AMD is not well established at present. Therefore, understanding the state of atrophic AMD is extremely important. 
     In atrophic AMD, so-called geographic atrophy (GA) is found in a predetermined region centered on a fovea. GA is specified from fundus images, fluorescein fluorescence fundus angiograms, fundus autofluorescnece inspection images, or the like, or GA is specified from tomographic images of the retina obtained using optical coherence tomography (for example, U.S. Unexamined Patent Application Publication No. 2015/0201829, Japanese Unexamined Patent Publication No. 2015-136626, Japanese Unexamined Patent Publication No. 2016-107148). The state of atrophic AMD can be understood by observing the specified GA (for example, Japanese Unexamined Patent Application Publication (Translation of PCT Application) No. 2014-505552). Further, Japanese Unexamined Patent Publication No. 2014-083266 and Japanese Unexamined Patent Publication No. 2014-083268 disclose methods for displaying trend analysis result of the layer thickness data obtained by analyzing data acquired using optical coherence tomography. 
     SUMMARY 
     In order to grasp the state of atrophic AMD (age-related macular degeneration), follow-up observation of morphology (form) (shape, size) or distribution of the regions with geographic atrophy (geographic atrophy regions) is effective. However, in the conventional techniques, the morphology or the distribution of the geographic atrophy region could not be observed in detail. Therefore, temporal change in the morphology or the distribution of the geographic atrophy region could not be grasped easily. Thereby, it was difficult to make an accurate diagnosis of atrophic AMD. 
     According to some embodiments of the present invention, a new technique for easy follow-up observation of morphology or distribution of an atrophy region in a fundus can be provided. 
     One aspect of some embodiments is an ophthalmologic information processing apparatus, including: an analyzer configured to specify one or more atrophy regions in a fundus of a subject&#39;s eye by analyzing data of the fundus acquired using optical coherence tomography; and a display controller configured to cause a plurality of images, each of which represents the one or more atrophy regions specified by the analyzer, to be displayed on a display means in chronological order, based on the plurality of data acquired at different timings. 
     Another aspect of some embodiments is an ophthalmologic system, including: a data acquisition unit configured to acquire the data by scanning the subject&#39;s eye using optical coherence tomography; the display means; and the ophthalmologic information processing apparatus according to the above. 
     Further, another aspect of some embodiments is an ophthalmologic information processing method, including: an analysis step of specifying one or more atrophy regions in a fundus of a subject&#39;s eye by analyzing data of the fundus acquired using optical coherence tomography; and a display step of causing a plurality of images, each of which represents the one or more atrophy regions specified in analysis step, to be displayed on a display means in chronological order, based on the plurality of data acquired at different timings. 
     Further, another aspect of some embodiments is a recording medium storing a program of causing a computer to execute each step of the ophthalmologic information processing method according to the above. 
    
    
     
       BRIEF EXPLANATION OF THE DRAWINGS 
         FIG. 1  is a schematic diagram illustrating an example of a configuration of an ophthalmologic system according to embodiments. 
         FIG. 2  is a schematic diagram illustrating an example of a configuration of an ophthalmologic apparatus according to the embodiments. 
         FIG. 3  is a schematic diagram illustrating an example of the configuration of the ophthalmologic information processing apparatus according to the embodiments. 
         FIG. 4  is a schematic diagram illustrating an example of the configuration of the ophthalmologic information processing apparatus according to the embodiments. 
         FIG. 5  is a schematic diagram illustrating an example of an operation flow of the ophthalmologic information processing apparatus according to the embodiments. 
         FIG. 6  is a schematic diagram illustrating an example of an operation flow of the ophthalmologic information processing apparatus according to the embodiments. 
         FIG. 7  is a schematic diagram for explaining an operation of the ophthalmologic information processing apparatus according to the embodiments. 
         FIG. 8  is a schematic diagram for explaining an operation of the ophthalmologic information processing apparatus according to the embodiments. 
         FIG. 9A  is a schematic diagram for explaining an operation of the ophthalmologic information processing apparatus according to the embodiments. 
         FIG. 9B  is a schematic diagram for explaining an operation of the ophthalmologic information processing apparatus according to the embodiments. 
         FIG. 10  is a schematic diagram for explaining an operation of the ophthalmologic information processing apparatus according to the embodiments. 
         FIG. 11  is a schematic diagram for explaining an operation of the ophthalmologic information processing apparatus according to the embodiments. 
         FIG. 12  is a schematic diagram for explaining an operation of the ophthalmologic information processing apparatus according to the embodiments. 
         FIG. 13  is a schematic diagram for explaining an operation of the ophthalmologic information processing apparatus according to the embodiments. 
         FIG. 14  is a schematic diagram for explaining an operation of the ophthalmologic information processing apparatus according to the embodiments. 
         FIG. 15  is a schematic diagram for explaining an operation of the ophthalmologic information processing apparatus according to the embodiments. 
         FIG. 16  is a schematic diagram illustrating an example of a configuration of the ophthalmologic information processing apparatus according to a modification example of the embodiments. 
         FIG. 17  is a schematic diagram for explaining an operation of the ophthalmologic information processing apparatus according to a modification example of the embodiments. 
         FIG. 18  is a schematic diagram for explaining an operation of the ophthalmologic information processing apparatus according to a modification example of the embodiments. 
         FIG. 19  is a schematic diagram illustrating an example of an operation flow of the ophthalmologic information processing apparatus according to a modification example of the embodiments. 
         FIG. 20  is a schematic diagram for explaining an operation of the ophthalmologic information processing apparatus according to a modification example of the embodiments. 
         FIG. 21  is a schematic diagram illustrating an example of the configuration of the ophthalmologic apparatus according to a modification example of the embodiments. 
     
    
    
     DETAILED DESCRIPTION 
     Referring now to the drawings, exemplary some embodiments of an ophthalmologic information processing apparatus, an ophthalmologic system, an ophthalmologic information processing method, a program, and a recording medium according to some embodiments of the present invention are described below. Any of the contents of the documents cited in the present specification and arbitrary known techniques may be applied to the embodiments below. 
     An ophthalmologic system according to the embodiments includes an ophthalmologic information processing apparatus. An ophthalmologic information processing method according to the embodiments is performed by the ophthalmologic information processing apparatus. The ophthalmologic information processing method according to the embodiments can be executed by a computer according to a program. 
     The ophthalmologic information processing apparatus according to the embodiments can perform predetermined analysis processing and predetermined display processing on data of a fundus of a subject&#39;s eye optically acquired using the ophthalmologic apparatus. The ophthalmologic apparatus according to some embodiments has the function of acquiring a front image of the fundus of the subject&#39;s eye. Examples of the ophthalmologic apparatus having the function of acquiring the front image of the fundus of the subject&#39;s eye include an optical coherence tomography (OCT, hereafter) apparatus, a fundus camera, a scanning laser ophthalmoscope (SLO), a slit lamp microscope, a surgical microscope, and the like. The ophthalmologic apparatus according to some embodiments has the function of measuring optical characteristics of the subject&#39;s eye. Examples of the ophthalmologic apparatus having the function of measuring optical characteristics of the subject&#39;s eye include a refractometer, a keratometer, a tonometer, a wave front analyzer, a specular microscope, a perimeter, and the like. The ophthalmologic apparatus according to some embodiments has the function of a laser treatment apparatus used for laser therapy. 
     [Ophthalmologic System] 
       FIG. 1  shows a block diagram of an example of the configuration of the ophthalmologic system according to the embodiments. The ophthalmologic system  1  according to the embodiments includes an ophthalmologic apparatus  10 , an ophthalmologic information processing apparatus (ophthalmologic image processing apparatus, ophthalmologic analysis apparatus)  100 , an operating apparatus  180 , and a display apparatus  190 . 
     The ophthalmologic apparatus  10  optically acquires data of the subject&#39;s eye. The ophthalmologic apparatus  10  optically acquires the data of the fundus of the subject&#39;s eye by scanning the fundus of the subject&#39;s eye. For example, the ophthalmologic apparatus  10  acquires three-dimensional OCT data of the fundus of the subject&#39;s eye using OCT. The ophthalmologic apparatus  10  can obtain an image of the fundus of the subject&#39;s eye from the acquired data of the subject&#39;s eye. The images of the fundus include a tomographic image of the fundus, and a front image of the fundus. Examples of the tomographic image of the fundus include a B scan image, and the like. Examples of the front image of the fundus include a C scan image, a shadowgram, a projection image, and the like. The ophthalmologic apparatus  10  sends the acquired data of the subject&#39;s eye to the ophthalmologic information processing apparatus  100 . 
     In some embodiments, the ophthalmologic apparatus  10  and the ophthalmologic information processing apparatus  100  are connected via a data communication network. The ophthalmologic information processing apparatus  100  according to some embodiments receives data from one of a plurality of ophthalmologic apparatuses  10  selectively connected via the data communication network. 
     The ophthalmologic information processing apparatus  100  performs analysis processing on each of a plurality of data in time series (in chronological order) of the fundus of the subject&#39;s eye acquired on different dates (time or timings) by the ophthalmologic apparatus  10 . The ophthalmologic information processing apparatus  100  stores each of the obtained plurality of analysis results in the storage unit (not shown) in association with a subject or a subject&#39;s eye and an acquired date (acquired date and time). The ophthalmologic information processing apparatus  100  according to some embodiments causes the obtained plurality of analysis results to be displayed in chronological order. The ophthalmologic information processing apparatus  100  according to some embodiments generates statistical information obtained from the plurality of analysis results. The analysis results include not only information obtained by performing analysis processing but also information obtained by processing the obtained information. 
     The ophthalmologic information processing apparatus  100  specifies a geographic atrophy region (atrophy region) by analyzing the data of the subject&#39;s eye, and forms an image for identifiably displaying the specified geographic atrophy region. The ophthalmologic information processing apparatus  100  according to some embodiments controls the display apparatus  190  to identifiably display the geographic atrophy region in the front image of the fundus or the tomographic image of the fundus. 
     The ophthalmologic information processing apparatus  100  causes a region corresponding to the geographic atrophy region in the front image of the fundus formed from the acquired data of the subject&#39;s eye to be highlighted (displayed in highlighted manner). The ophthalmologic information processing apparatus  100  according to some embodiments forms the front image of the fundus from the acquired data of the subject&#39;s eye, performs position matching between the formed front image and the specified geographic atrophy region, and causes the front image of the fundus, on which the image representing the geographic atrophy region is overlaid, to be displayed, the image having been performed position matching. 
     The ophthalmologic information processing apparatus  100  causes the region corresponding to the geographic atrophy region in the tomographic image of the fundus formed from the acquired data of the subject&#39;s eye to be highlighted. The ophthalmologic information processing apparatus  100  according to some embodiments forms the tomographic image of the fundus from the acquired data of the subject&#39;s eye, performs position matching between the formed tomographic image and the specified geographic atrophy region, and causes the tomographic image of the fundus, on which the image representing the geographic atrophy region is overlaid, to be displayed, the image having been performed position matching. 
     The ophthalmologic information processing apparatus  100  obtains parameters representing morphology or distribution of the geographic atrophy region for each of a plurality of geographic atrophy regions specified from a plurality of data of the fundus. Examples of the parameter include an area of each geographic atrophy region, an outer perimeter of each geographic atrophy region, a total value of area(s) of the geographic atrophy region(s), a total value of outer perimeter(s) of the geographic atrophy region(s), the number of the geographic atrophy regions, a fraction (density) of the geographic atrophy region(s) occupied in a predetermined region, information representing positional relationship of the geographic atrophy region with respect to a reference position, and the like. The ophthalmologic information processing apparatus  100  according to some embodiments causes the obtained parameter to be displayed on the display apparatus  190  in chronological order. The ophthalmologic information processing apparatus  100  according to some embodiments causes statistical information of the obtained parameter(s) to be displayed on the display apparatus  190 . 
     The operating apparatus  180  and the display apparatus  190  provide the function for exchanging information between the ophthalmologic information processing apparatus  100  and the user, such as displaying information, inputting information, and inputting operation instructions, as a user interface unit. The operating apparatus  180  includes an operating device such as a lever, a button, a key, and pointing device. The operating apparatus  180  according to some embodiments includes a microphone for inputting information using sound. The display apparatus  190  includes a display device such as a flat-panel display. In some embodiments, the functions of the operating apparatus  180  and the display apparatus  190  are realized using a device in which a device having an input function such as a touch panel display and a device having a display function are integrated. In some embodiments, the operating apparatus  180  and the display apparatus  190  include a graphical user interface (GUI) for inputting and outputting information. 
     The ophthalmologic information processing apparatus  100  causes the parameter(s) representing the morphology or the distribution of the one or more geographic atrophy regions designated using the operating apparatus  180  among the specified plurality of geographic atrophy regions to be displayed on the display apparatus  190  in chronological order. The ophthalmologic information processing apparatus  100  according to some embodiments causes statistical information of parameters, the parameters representing morphology or distribution of one or more geographic atrophy regions designated using the operating apparatus  180  among the specified plurality of geographic atrophy regions, to be displayed on the display apparatus  190 . 
     [Ophthalmologic Apparatus] 
       FIG. 2  shows a block diagram of an example of the configuration of the ophthalmologic apparatus  10  according to the embodiments. 
     The ophthalmologic apparatus  10  includes an optical system for acquiring OCT data of the subject&#39;s eye. The ophthalmologic apparatus  10  has a function of performing swept source OCT, but the embodiments are not limited to this. For example, the type of OCT is not limited to swept source OCT, and it may be the spectral domain OCT or the like. The swept source OCT is a technique that splits light from a wavelength sweep type (i.e., a wavelength scanning type) light source into measurement light and reference light; superposes the measurement light returning from the object to be measured with the reference light to generate interference light; detects the interference light with a balanced photodiode or the like; and applies the Fourier transform etc. to the detection data acquired through the tuning of wavelengths and the scanning of the measurement light to form an image. The spectral domain OCT is a technique that splits light from a low coherence light source into measurement light and reference light; superposes the measurement light returning from the object to be measured with the reference light to generate interference light; detects the spectral distribution of the interference light with a spectrometer; and applies the Fourier transform etc. to the detected spectral distribution to form an image. 
     The ophthalmologic apparatus  10  includes a controller  11 , a data acquisition unit  12 , an image forming unit  13 , and a communication unit  14 . 
     The controller  11  controls each part of the ophthalmologic apparatus  10 . In particular, the controller  11  controls the data acquisition unit  12 , the image forming unit  13 , and the communication unit  14 . 
     The data acquisition unit  12  acquires data (three-dimensional OCT data) of the subject&#39;s eye by scanning the subject&#39;s eye using OCT. The data acquisition unit  12  includes an interference optical system  12 A and a scan optical system  12 B. 
     The interference optical system  12 A splits light from the light source (wavelength sweep type light source) into measurement light and reference light, makes returning light of the measurement light through the subject&#39;s eye and the reference light having traveled through a reference optical path interfere with each other to generate interference light, and detects the interference light. The interference optical system  12 A includes at least a fiber coupler and a light receiver such as a balanced photodiode. The fiber coupler splits the light from the light source into the measurement light and the reference light, and makes returning light of the measurement light through the subject&#39;s eye and the reference light having traveled through a reference optical path interfere with each other to generate interference light. The light receiver detects the interference light generated by the fiber coupler. The interference optical system  12 A may include the light source. 
     The scan optical system  12 B changes an incident position of the measurement light on the fundus of the subject&#39;s eye by deflecting the measurement light generated by the interference optical system  12 A, under the control of the controller  11 . The scan optical system  12 B includes, for example, an optical scanner disposed at a position optically conjugate with a pupil of the subject&#39;s eye. The optical scanner includes, for example, a galvano mirror that scans with the measurement light in the horizontal direction, a galvano mirror that scans with the measurement light in the vertical direction, and a mechanism that independently drives the galvano mirrors. With this, it is possible to scan the measurement light in an arbitrary direction in the fundus plane. 
     A detection result (detection signal) of the interference light obtained by the interference optical system  12 A is an interference signal representing the spectrum of the interference light. 
     The image forming unit  13  forms image data of a tomographic image of the fundus of the subject&#39;s eye based on the data of the subject&#39;s eye acquired by the data acquisition unit  12 , under the control of the controller  11 . This processing includes noise removal (noise reduction), filtering, fast Fourier transform (FFT), and the like. The image data acquired in this manner is a data set including a group of image data formed by imaging the reflection intensity profiles of a plurality of A lines. Here, the A lines are the paths of the measurement light in the subject&#39;s eye. In order to improve the image quality, it is possible to repeatedly perform scan with the same pattern a plurality of times to collect a plurality of data sets, and to compose (i.e., average) the plurality of data sets. 
     The image forming unit  13  can form a B scan image, a C scan image, a projection image, a shadowgram, etc., by performing various renderings on the acquired three-dimensional OCT data. An image in an arbitrary cross section such as the B scan image or the C scan image is formed by selecting pixels (voxels) on a designated cross section from the three-dimensional OCT data. The projection image is formed by projecting the three-dimensional OCT data in a predetermined direction (Z direction, depth direction, A scan direction). The shadowgram is formed by projecting a part of the three-dimensional OCT data (for example, partial data corresponding to a specific layer) in a predetermined direction. 
     The ophthalmologic apparatus  10  according to some embodiments includes a data processor that performs various kinds of data processing (e.g., image processing) and various kinds of analysis processing on the image formed by the image forming unit  13 . For example, the data processor performs various correction processes such as brightness correction and dispersion correction of images. The data processor can form volume data (voxel data) of the subject&#39;s eye by performing known image processing such as interpolation processing for interpolating pixels between tomographic images. In the case of displaying an image based on the volume data, the data processor performs rendering processing on the volume data so as to form a pseudo three-dimensional image viewed from a specific line-of-sight direction. 
     Each of the controller  11  and the image forming unit  13  includes a processor. The processor includes, for example, a circuit(s) such as, for example, a CPU (central processing unit), a GPU (graphics processing unit), an ASIC (application specific integrated circuit), and a PLD (programmable logic device). Examples of PLD include a simple programmable logic device (SPLD), a complex programmable logic device (CPLD), and a field programmable gate array (FPGA). The functions of the image forming unit  13  are realized by an image forming processor. In some embodiments, both of the functions of the controller  11  and the image forming unit  13  are realized by a single processor. In some embodiments, in case that the ophthalmologic apparatus  10  includes the data processor, the functions of the data processor are also realized by a processor. 
     The processor realizes, for example, the function according to the embodiments by reading out a computer program stored in a storage circuit or a storage device and executing the computer program. At least a part of the storage circuit or the storage apparatus may be included in the processor. Further, at least a part of the storage circuit or the storage apparatus may be provided outside of the processor. 
     The storage apparatus etc. stores various types of data. Examples of the data stored in the storage apparatus etc. include data (measurement data, photographic data, etc.) acquired by the data acquisition unit  12  and information related to the subject and the subject&#39;s eye. The storage apparatus etc. may store a variety of computer programs and data for the operation of each part of the ophthalmologic apparatus  10 . 
     The communication unit  14  performs communication interface processing for sending or receiving information with the ophthalmologic information processing apparatus  100  under the control of the controller  11 . 
     The ophthalmologic apparatus  10  according to some embodiments sends the image data of the subject&#39;s eye formed by the image forming unit  13  to the ophthalmologic information processing apparatus  100 . 
     The ophthalmologic apparatus  10  according to some embodiments includes a fundus camera for acquiring an image of the fundus of the subject&#39;s eye, a scanning laser ophthalmoscope for acquiring an image of the fundus of the subject&#39;s eye, or a slit lamp microscope. In some embodiments, the fundus image acquired by the fundus camera is a fluorescein fluorescence fundus angiogram or a fundus autofluorescnece inspection image. 
     [Ophthalmologic Information Processing Apparatus] 
       FIGS. 3 and 4  show block diagrams of examples of the configuration of the ophthalmologic information processing apparatus  100  according to the embodiments.  FIG. 3  shows a functional block diagram of the ophthalmologic information processing apparatus  100 .  FIG. 4  shows a functional block diagram of an analyzer  200  of  FIG. 3 . 
     The ophthalmologic information processing apparatus  100  performs analysis processing on each of the plurality of data in time series of the fundus of the subject&#39;s eye acquired on different dates by the ophthalmologic apparatus  10 . The ophthalmologic information processing apparatus  100  stores each of the plurality of analysis results obtained by performing analysis processing in a storage unit  112  described after, in association with the subject or the subject&#39;s eye and an inspection date (inspection date and time). The ophthalmologic information processing apparatus  100  according to some embodiments stores each of the obtained plurality of analysis results in the storage apparatus connected via a predetermined network, in association with the subject&#39;s eye and the inspection date. The ophthalmologic information processing apparatus  100  caused the plurality of analysis results obtained by performing analysis processing to be displayed in chronological order. 
     The ophthalmologic information processing apparatus  100  analyzes the data of the fundus of the subject&#39;s eye acquired by the ophthalmologic apparatus  10  to specify a geographic atrophy region on the fundus. The ophthalmologic information processing apparatus  100  causes the specified geographic atrophy region in the front image or the tomographic image of the fundus to be displayed on the display apparatus  190  so as to be identifiable. The ophthalmologic information processing apparatus  100  causes images representing the plurality of geographic atrophy regions specified based on the plurality of the data of the fundus of the subject&#39;s eye with different inspection dates to be displayed on the display apparatus  190  in chronological order. The ophthalmologic information processing apparatus  100  obtains parameters representing morphology or distribution of the geographic atrophy region for each of the specified plurality of geographic atrophy regions, and causes the obtained parameters to be displayed on the display apparatus  190  in chronological order. The ophthalmologic information processing apparatus  100  causes statistical information of the obtained parameter(s) to be displayed on the display apparatus  190 . 
     The ophthalmologic information processing apparatus  100  includes a controller  110 , an image forming unit  120 , a data processor  130 , and a communication unit  140 . 
     The image forming unit  120  forms a B scan image, a C scan image, a projection image, a shadowgram, or the like from the three-dimensional OCT data acquired by the ophthalmologic apparatus  10  under the control of the controller  110 . The image forming unit  120  can form the above image in the same manner as the image forming unit  13 . 
     The data processor  130  performs various kinds of data processing (e.g., image processing) and various kinds of analysis processing on an image formed by the image forming unit  120 . For example, the data processor  130  performs various correction processes such as brightness correction and dispersion correction of images. The data processor  130  can form volume data (voxel data) of the subject&#39;s eye by performing known image processing such as interpolation processing for interpolating pixels between tomographic images. In the case of displaying an image based on the volume data, the data processor  130  performs rendering processing on the volume data so as to form a pseudo three-dimensional image viewed from a specific line-of-sight direction. 
     The data processor  130  performs predetermined data processing on the formed image of the subject&#39;s eye. The processing unit  130  includes the analyzer  200  and a position matching processor  210 . 
     The analyzer  200  performs predetermined analysis processing on the image data of the fundus of the subject&#39;s eye formed by the image forming unit  120  (or the image data of the fundus of the subject&#39;s eye acquired by the ophthalmologic apparatus  10 ). Examples of the analysis processing according to some embodiments include specifying processing of the geographic atrophy region in the fundus, generating processing of the distribution information of the geographic atrophy region, generating processing of the morphology information of the geographic atrophy region, statistical processing of the distribution information or the morphology information, generating processing of the distribution information of layer thickness in the fundus, and the like. 
     The analyzer  200  include a segmentation processor  201 , a region specifying unit  202 , a distribution information generator  203 , a morphology information generator  204 , and a layer thickness distribution information generator  205 . Each part of the analyzer  200  performs the following processing on each of the plurality of data of the fundus of the subject&#39;s eye. 
     The segmentation processor  201  specifies a plurality of layer regions in the A scan direction based on the data of the subject&#39;s eye acquired by the ophthalmologic apparatus  10 . The segmentation processor  201  according to some embodiments analyzes the three-dimensional OCT data to specify a plurality of partial data sets corresponding to a plurality of tissues of the subject&#39;s eye. The segmentation processing is image processing for specifying specific tissues and/or tissue boundaries. For example, the segmentation processor  201  obtains the gradients of the pixel values (i.e., brightness values) in each A scan image included in the OCT data, and specifies a position where the gradient value is large to be a tissue boundary. Note that the A scan image is one-dimensional image data extending in the depth direction of the fundus. The depth direction of the fundus is defined as, for example, the Z direction, the incident direction of the OCT measurement light, the axial direction, the optical axis direction of the interference optical system, or the like. 
     In a typical example, the segmentation processor  201  specifies a plurality of partial data sets corresponding to a plurality of layer tissues of the fundus by analyzing the three-dimensional OCT data representing the fundus (the retina, the choroid, etc.) and the vitreous body. Each partial data set is defined by the boundaries of the layer tissue. Examples of the layer tissue specified as the partial data set include a layer tissue constituting the retina. Examples of the layer tissue constituting the retina include the inner limiting membrane, the nerve fiber layer, the ganglion cell layer, the inner plexiform layer, the inner nuclear layer, the outer plexiform layer, the outer nuclear layer, the external limiting membrane, the photoreceptor layer, the retinal pigment epithelium layer, and the like. The segmentation processor  201  can specify a partial data set corresponding to the Bruch membrane, the choroid, the sclera, the vitreous body, or the like. The segmentation processor  201  according to some embodiments specifies a partial data set corresponding to the site of lesion. Examples of the site of lesion include a detachment part, an edema, a bleeding site, a tumor, a drusen, and the like. 
     The segmentation processor  201  according to some embodiments specifies, as the Bruch membrane, a layer tissue for a predetermined number of pixels on the sclera side with respect to the RPE, and acquires, as the partial data set of the Bruch membrane, the partial data set corresponding to the layer tissue. 
     The region specifying unit  202  specifies a region corresponding to two layer tissues for specifying the geographic atrophy region by analyzing a plurality of partial data sets of the layer tissues specified by the segmentation processor  201 . The region specifying unit  202  according to some embodiments specifies a first region and a second region, the first region corresponding to a layer tissue on the sclera side with respect to a region corresponding to the Bruch membrane, the second region corresponding to a layer region from a region corresponding to the inner limiting membrane to a region corresponding to the RPE. In some embodiments, the second region is a region corresponding to a layer tissue on the cornea side from the region corresponding to the Bruch membrane. 
     The distribution information generator  203  obtains a contrast ratio for each A scan based on the pixel values in the first region and the second region which are specified by the region specifying unit  202 , and generates two-dimensional distribution information of the contrast ratio in the fundus plane (plane orthogonal to the A scan direction). In some embodiments, the distribution information generator  203  generates the distribution information of the ratio of the integrated value of the pixel values of the first region specified by the region specifying unit  202  and the integrated value of the pixel values of the second region specified by the layer region specifying unit  202 , for each A scan. The distribution information generator  203  according to some embodiments obtains, as the contrast ratio, the ratio of the integrated value of the pixel values in the A scan direction of the second region to the integrated value of the pixel values in the A scan direction of the first region, and generates the two-dimensional distribution information of the obtained contrast ratio. The two-dimensional distribution information of the contrast ratio is hereinafter referred to as a contrast map. 
     The analyzer  200  specifies a position where the contrast ratio is large, as a position where signal components are attenuated due to the geographic atrophy, in the contrast map generated by the distribution information generator  203 . The analyzer  200  specifies the geographic atrophy region based on the specified position. For example, the analyzer  200  specifies, as the geographic atrophy region, a region including positions where the contrast ratio is equal to or larger than a predetermined threshold value, in the contrast map generated by the distribution information generator  203 . Techniques related to such a method for specifying a geographic atrophy region are disclosed in U.S. Unexamined Patent application Publication No. 2015/0201829, Japanese Unexamined Patent Application Publication No. 2015-136626, or Japanese Unexamined Patent Application Publication No. 2016-107148. 
     The morphology information generator  204  generates morphology information representing morphology of the specified geographic atrophy region. Examples of the morphology information include the area of the geographic atrophy region(s), the outer perimeter of the geographic atrophy region(s), and the like. The morphology information generator  204  can obtain the area of the geographic atrophy region(s) or the outer perimeter of the geographic atrophy region(s) by applying a known method to the image in which the geographic atrophy region(s) is(are) depicted. The morphology information generator  204  according to some embodiments generates the morphology information for each of the specified geographic atrophy regions. The morphology information generator  204  according to some embodiments generates, as the morphology information, the total value of morphological parameters (areas, outer perimeters) for each of the specified geographic atrophy regions. In some embodiments, the morphology information includes the number of the specified geographic atrophy regions. 
     The layer thickness distribution information generator  205  specifies a thickness in the A scan direction of each of the layer tissues by analyzing the partial data sets of the plurality of the layer tissues specified by the segmentation processor  201 , and generates the two-dimensional distribution information of the layer thickness of the each layer in the fundus plane. The layer thickness distribution information generator  205  according to some embodiments generates the two-dimensional distribution information (distribution information of the plane orthogonal to the A scan direction) of the layer thickness of the one or more layer tissues designated using the operating apparatus  180 . The layer thickness distribution information generator  205  according to some embodiments generates the two-dimensional distribution information of the layer thickness of at least one of the inner limiting membrane, the nerve fiber layer (NFL), the ganglion cell layer (GCL), the inner plexiform layer (IPL), the inner nuclear layer (INL), the outer plexiform layer (OPL), the outer nuclear layer (ONL), the external limiting membrane (ELM), the retinal pigment epithelium layer (RPE), the choroid, the sclera, and the choroidal-scleral interface (CSI), or two or more adjacent layers. 
     The analyzer  200  performs trend analysis processing based on a plurality of analysis processing results obtained by performing the above analysis processing on each of the plurality of data of the fundus of the subject&#39;s eye. The trend analysis processing includes processing for generating information indicating temporal change in the plurality of analysis processing results. Examples of the information indicating the temporal change include a graph in which each analysis processing result is plotted in chronological order, a graph in which each analysis processing result is plotted on the time axis, an analysis map representing the distribution of the analysis processing result at each position in the fundus plane, and the like. In some embodiments, the information indicating temporal change includes a regression line or a regression curve obtained by regression analysis, a p-value, a predicted value of the analysis result at predetermined future time, event information, information indicating temporal change based on normal eye data, and the like. In some embodiments, a target for the analysis processing is designated using the operating apparatus  180 . 
     The position matching processor  210  performs position matching (registration) between a front image of the fundus formed by the image forming unit  120  and an image representing the geographic atrophy region specified by the analyzer  200 . The position matching processor  210  performs position matching between the tomographic image of the fundus formed by the image forming unit  120  and the image representing the geographic atrophy region specified by the analyzer  200 . The position matching processor  210  can perform position matching using known processing such as affine transformation for performing enlargement, reduction, rotation, or the like of the image. 
     The position matching processing includes, for example, processing for detecting characteristic sites from the both images and processing for performing position matching of the both images on the base of the both characteristic sites. In some embodiments, the position matching processing includes processing for specifying a position in the image representing the geographic atrophy region in the front image or the tomographic image using position information of the geographic atrophy region in the front image or the tomographic image of the fundus and processing for performing position matching of the image representing the specified geographic atrophy region with respect to the front image or the tomographic image. 
     The communication unit  140  performs communication interface processing for sending or receiving information with the communication unit  14  of the ophthalmologic information processing apparatus  100  under the control of the controller  110 . 
     The controller  110  controls each part of the ophthalmologic information processing apparatus  100 . In particular, the controller  110  controls the image forming unit  120 , the data processor  130 , and the communication unit  140 . The controller  110  includes the main controller  111  and a storage unit  112 . The main controller  111  includes the display controller  111 A. 
     The display controller  111 A causes the various information to be displayed on the display apparatus  190 . For example, the display controller  111 A causes the fundus image (front image, tomographic image) of the subject&#39;s eye formed by the image forming unit  120  or the image of the data processing result (including the analysis processing result) by the data processor  130  to be displayed on the display apparatus  190 . In particular, the display controller  111 A causes the fundus image of the subject&#39;s eye to be displayed on the display apparatus  190 , and causes the region corresponding to the geographic atrophy region in the fundus image to be displayed on the display apparatus  190  so as to be identifiable. The display controller  111 A according to some embodiments causes the fundus image of the subject&#39;s eye to be displayed on the display apparatus  190 , and causes the region corresponding to the geographic atrophy region in the fundus image to be highlighted on the display apparatus  190 . For example, the display controller  111 A causes the geographic atrophy region or its background region such that the brightness of the pixels in the geographic atrophy region or its background region is higher than the brightness of the pixels in the other regions to be displayed. The display controller  111 A according to some embodiments causes an image in which the image representing the geographic atrophy region performed position matching by the position matching processor  210  is overlaid on the fundus image to be displayed on the display apparatus  190 . 
     Further, the display controller  111 A can cause the images representing the geographic atrophy regions specified from the plurality of the data of the fundus with different inspection dates to be displayed on the display apparatus  190  in chronological order. The display controller  111 A according to some embodiments causes a plurality of geographic atrophy region images to be displayed on the display apparatus  190  in chronological order. In each of the plurality of geographic atrophy region images, the image representing the geographic atrophy region in which position matching is performed by the position matching processor  210  is overlaid on the fundus image or the tomographic image. 
     Further, the display controller  111 A causes the morphology information generated by the morphology information generator  204  to be displayed on the display apparatus  190 . The display controller  111 A according to some embodiments causes the morphology information generated by the morphology information generator  204  to be displayed on the display apparatus  190  in association with the geographic atrophy region corresponding to the morphology information. The display controller  111 A according to some embodiments causes a plurality of morphology information generated based on the time-series plurality of the data of the fundus by the morphology information generator  204  to be displayed on the display apparatus  190  in chronological order. The display controller  111 A according to some embodiments causes the morphology information (the morphology information of each geographic atrophy region, the total value of the morphology information of the one or more geographic atrophy regions) to be displayed on the display apparatus  190  in chronological order. Here, the morphology information corresponds to the one or more geographic atrophy regions for each of the one or more geographic atrophy regions designated using the operating apparatus  180 . 
     The controller  110  controls each part of the ophthalmologic system  1  based on operation instruction signal corresponding to the operation content of the user on the operating apparatus  180 . 
     Each of the controller  110 , the image forming unit  120 , and the data processor  130  includes a processor. The functions of the image forming unit  120  is realized by an image forming processor. The functions of the data processor  130  is realized by a data processing processor. In some embodiments, at least two functions of the controller  110 , the image forming unit  120 , and the data processor  130  are realized by a single processor. 
     The storage unit  112  stores various kinds of data. Examples of the data stored in the storage unit  112  include data (measurement data, photographic data, etc.) acquired by the ophthalmologic apparatus  10 , image data formed by the image forming unit  120 , data processing result(s) obtained by the data processor  130 , information related to the subject and the subject&#39;s eye, and the like. The storage unit  112  may store a variety of computer programs and data for the operation of each part of the ophthalmologic information processing apparatus  100 . 
     The operating apparatus  180  is an example of the “designating unit” according to the embodiments. The display apparatus  190  is an example of the “display means” according to the embodiments. The geographic atrophy region is an example of the “atrophy region” according to the embodiments. 
     Operation Example 
     Examples of the operation of the ophthalmologic information processing apparatus  100  according to some embodiments will be described. 
       FIG. 5  shows an example of the operation of the ophthalmologic information processing apparatus  100  according to the embodiments.  FIG. 5  shows a flowchart of an example of the operation of the ophthalmologic information processing apparatus  100 . In  FIG. 5 , it is assumed that the three-dimensional OCT data of the subject&#39;s eye acquired by the ophthalmologic apparatus  10  has already stored in the ophthalmologic information processing apparatus  100  (storage unit  112 ). 
     (S 1 : Select Subject) 
     The user selects a subject by inputting the subject ID using the operating apparatus  180 . 
     (S 2 : Display Inspection Data) 
     The storage unit  112  stores a database in which the inspection data of the subject is associated in advance corresponding to the subject ID. The controller  110  searches the database using the subject ID input in step S 1  as a search key, and acquires the inspection data corresponding to the subject ID. The display controller  111 A causes the inspection data corresponding to the subject ID acquired by searching the database to be displayed on the display apparatus  190 . The inspection data includes one or more fundus images of the subject&#39;s eye acquired in the past inspection. 
     (S 3 : Select Image of Subject&#39;s Eye) 
     The ophthalmologic information processing apparatus  100  causes the user to select the image of the subject&#39;s eye to be analyzed among the one or more images of the subject&#39;s eye in the inspection data of the subject displayed on the display apparatus  190  in step S 2 . The subject operates the operating apparatus  180  to select the image of the subject&#39;s eye to be analyzed. The controller  110  receives the operation instruction signal corresponding to the operation content of the operating apparatus  180  by the user. 
     (S 4 : Display) 
     The display controller  111 A selects the image of the subject&#39;s eye designated based on the operation instruction signal input in step S 3  to cause the selected image of the subject&#39;s eye to be displayed on the display apparatus  190 . 
     (S 5 : Perform Region Analysis?) 
     Next, the controller  110  determines whether or not to perform analysis of the geographic atrophy region for the image of the subject&#39;s eye displayed in step S 4 . The controller  110  can determine whether or not to perform analysis of the geographic atrophy region based on the operation instruction signal corresponding to the operation content to instruct analysis execution on the operating apparatus  180 . 
     When it is determined that the analysis of the geographic atrophy region is to be performed (S 5 : Y), the operation of the ophthalmologic information processing apparatus  100  proceeds to step S 6 . When it is determined that the analysis of the geographic atrophy region is not to be performed (S 5 : N), the operation of the ophthalmologic information processing apparatus  100  proceeds to step S 9 . 
     (S 6 : Specify Atrophy Region) 
     When it is determined that the analysis of the geographic atrophy region is to be performed in step S 5  (S 5 : Y), the controller  110  controls the analyzer  200  to specify the geographic atrophy region by performing analysis of the geographic atrophy region. Details of step S 6  will be described later. The controller  110  stores region specific information for specifying a position or a shape of the geographic atrophy region on the fundus in the storage unit  112  in association with the subject or the subject&#39;s eye and the inspection date. 
     (S 7 : Perform Analysis of Morphology) 
     Subsequently, the controller  110  controls the morphology information generator  204  to calculate an area and an outer perimeter of each of the geographic atrophy regions specified in step S 6 . The morphology information generator  204  generates the morphology information including the total value of the areas of the geographic atrophy regions, the total value of the outer perimeters of the geographic atrophy regions, and the number of the specified geographic atrophy regions. The controller  110  stores the morphology information generated in step S 7  along with the above region specific information in the storage unit  112  in association with the subject or the subject&#39;s eye and the inspection date. 
     The controller  110  according to some embodiments controls the layer thickness distribution information generator  205  to generate the two-dimensional distribution information of the layer thickness of each layer in the fundus. The controller  110  stores the distribution information generated in step S 7  along with the above region specific information in the storage unit  112  in association with the subject or the subject&#39;s eye and the inspection date. 
     (S 8 : Display) 
     Next, the controller  110  controls the position matching processor  210  to perform position matching between the front image of the fundus formed by the image forming unit  120  in advance and the image representing the geographic atrophy region specified in step S 6 . The display controller  111 A causes the image representing the geographic atrophy region superimposed on the front image of the fundus to be displayed on the display apparatus  190 . Here, the front image of the fundus may be a shadowgram ranging from RPE to the Bruch membrane. Further, the display controller  111 A causes the morphology information generated in step S 7  to be displayed on the display apparatus  190  in association with the geographic atrophy region corresponding to the morphology information. 
     In the same manner, the controller  110  controls the position matching processor  210  to perform position matching between the tomographic image of the fundus formed by the image forming unit  120  in advance and the image representing the geographic atrophy region specified in step S 6 . The display controller  111 A causes the image representing the geographic atrophy region superimposed on the tomographic image of the fundus to be displayed on the display apparatus  190 . Further, the display controller  111 A causes the morphology information generated in step S 7  to be displayed on the display apparatus  190  in association with the geographic atrophy region corresponding to the morphology information. This terminates the operation of the ophthalmologic information processing apparatus  100  (END). 
     (S 9 : Perform Trend Analysis?) 
     When it is not determined that the analysis of the geographic atrophy region is to be performed in step S 5  (S 5 : N), the controller  110  determines whether or not to perform trend analysis on the image of the subject&#39;s eye displayed in step S 4 . The controller  110  can determine whether or not to perform trend analysis based on the operation instruction signal corresponding to the operation content for instructing analysis execution on the operating apparatus  180 . 
     When it is determined that the trend analysis is to be performed (S 9 : Y), the operation of the ophthalmologic information processing apparatus  100  proceeds to step S 10 . When it is determined that the trend analysis is not to be performed (S 9 : N), the ophthalmologic information processing apparatus  100  terminates the operation (END). 
     (S 10 : Perform Trend Analysis Processing) 
     When it is determined that the trend analysis is to be performed in step S 9  (S 9 : Y), the controller  110  controls the analyzer  200  to perform trend analysis processing. In step S 10 , in case that a predetermined analysis processing result of the data of the subject&#39;s eye is not obtained, the specification of the geographic atrophy region in step S 6  and the morphology analysis in step S 7  may be performed as necessary. For example, the analyzer  200  generates a trend graph of the areas of the geographic atrophy regions or a trend graph of the outer perimeters of the geographic atrophy regions. 
     (S 11 : Display in Chronological Order) 
     The display controller  111 A causes a plurality of atrophy region images to be displayed on the display apparatus  190  in chronological order. In each of the plurality of atrophy region images, the image representing the geographic atrophy region is overlaid on the fundus image or the tomographic image. Further, the display controller  111 A causes a plurality of two-dimensional distribution information of the layer thickness in the fundus plane generated by the layer thickness distribution information generator  205  to be displayed in a predetermined display region of the display apparatus  190  in chronological order. 
     (S 12 : Display Trend Graph) 
     The display controller  111 A causes the trend graph, which is generated in step S 10 , to be displayed in the predetermined display region of the display apparatus  190 . This terminates the operation of the ophthalmologic information processing apparatus  100  (END). 
     Next, an example of the operation of step S 6  in  FIG. 5  will be described while referring to  FIGS. 6 to 12 . 
       FIG. 6  shows a flow chart of an example of the operation of step S 6  in  FIG. 5 .  FIG. 7  is an operation explanatory diagram for step S 22 .  FIG. 8  is an operation explanatory diagram for step S 23 .  FIG. 9A  is an operation explanatory diagram for step S 24 .  FIG. 9B  is an operation explanatory diagram for step S 25 .  FIG. 10  is an operation explanatory diagram for step S 26 .  FIGS. 11 and 12  are operation explanatory diagrams for step S 27 . 
     (S 21 : Acquire B Scan Image) 
     When it is determined that the analysis of the geographic atrophy region is to be performed (S 5 : Y), the controller  110  reads out the data of the fundus of the subject&#39;s eye stored in the storage unit  112 , and controls the image forming unit  120  to form a B scan image based on the read data. In some embodiments, in step S 21 , the B scan image is acquired from the ophthalmologic apparatus  10 . 
     (S 22 : Perform Segmentation Processing) 
     The controller  110  controls the segmentation processor  201  to perform segmentation processing on the B scan image acquired in step S 21 . The segmentation processor  201  specifies a plurality of layer regions in the A scan direction for the B scan image acquired in step S 21 . As shown in  FIG. 7 , the segmentation processor  201  specifies the inner limiting membrane  300 , the nerve fiber layer, the ganglion cell layer, the inner plexiform layer, the inner nuclear layer, the outer plexiform layer, the outer nuclear layer, the external limiting membrane, the photoreceptor layer, the RPE  301  which constitute the retina, in the B scan image IMG 1 . Further, the segmentation processor  201  specifies, as the Bruch membrane  302 , a layer tissue for a predetermined number of pixels on the sclera side with respect to the specified RPE  301 . 
     (S 23 : Generate Contrast Map) 
     Subsequently, the controller  110  controls the data processor  130  to generate the contrast map using the result of the segmentation processing in step S 22 . That is, the region specifying unit  202  specifies the first region and the second region by analyzing the partial data sets of the plurality of layer regions specified by the segmentation processor  201 . The first region corresponds to the layer tissues on the sclera side from the region corresponding to the Bruch membrane  302 . The second region corresponds to the layer tissues from the region corresponding to the inner limiting membrane  300  to the region corresponding to the RPE  301 . 
     The distribution information generator  203  obtains, as the contrast ratio, the ratio of the integrated value of the pixel values in the A scan direction of the second region to the integrated value of the pixel values in the A scan direction of the first region, and generates the two-dimensional distribution information of the obtained contrast ratio ( FIG. 8 ). 
     (S 24 : Perform Smoothing Processing) 
     Next, the controller  110  controls the data processor  130  to perform smoothing processing on the contrast map generated in step S 23 . Focusing on the fact that the change in pixel value between adjacent pixels generally tends to be small and that the noise component superimposed on the pixel value is also similar, the contrast map from which the noise component is removed by performing smoothing processing can be obtained ( FIG. 9A ). 
     (S 25 : Perform Binarization Processing) 
     Subsequently, the controller  110  controls the data processor  130  to perform binarization processing on the contrast map obtained after the smoothing processing in step S 24 . Thereby, a binarized map as shown in  FIG. 9B  is obtained. 
     (S 26 : Search Region) 
     The controller  110  controls the analyzer  200  to search a region by applying a known region expansion method to the binarized map obtained in step S 25  ( FIG. 10 ). 
     (S 27 : Extract Contour) 
     The controller  110  controls the analyzer  200  to extract the contour of the region by performing known contour extraction processing on the region obtained by searching in step S 26  ( FIG. 11 ). The analyzer  200  specifies the geographic atrophy region based on the extracted contour ( FIG. 12 ). This terminates the processing of step S 6  in  FIG. 5  (END). 
       FIG. 13  shows an example of the analysis information displayed on the display apparatus  190  in step S 8  in some embodiments. 
     For example, in step S 8 , the display controller  111 A causes the image IMGX representing the geographic atrophy region superimposed on the shadowgram (the front image of the fundus) IMG 2  to be displayed on the display apparatus  190 . 
     Further, the display controller  111 A can cause the morphology information  350  including the total value of the area(s) of the geographic atrophy region(s), the total value of the outer perimeter(s) of the geographic atrophy region(s), and the number of the geographic atrophy region(s) to be displayed on the display apparatus  190 . The display controller  111 A according to some embodiments causes the morphology information of each of the geographic atrophy regions to be displayed on the display apparatus  190  in association with the geographic atrophy region corresponding to the morphology information. Thereby, the morphology of each of the geographic atrophy regions can be observed in detail. 
       FIG. 14  shows another example of the analysis information displayed on the display apparatus  190  in step S 8  in some embodiments. 
     For example, in step S 8 , the display controller  111 A causes the image IMGY (image of B scan cross section) representing the geographic atrophy region superimposed on the B scan image IMG 3  of the fundus to be displayed on the display apparatus  190 . Thereby, the morphology of the geographic atrophy region can be observed in the B scan image in detail. 
       FIG. 15  shows an example of the trend analysis information displayed on the display apparatus  190  in steps S 11  and S 12  in some embodiments. 
     For example, in steps S 11  and S 12 , the display controller  111 A causes the plurality of atrophy region images to be displayed in a first chronological image display region (first time-series image display region) AR 1  of the display apparatus  190  in chronological order. In each of the plurality of atrophy region images, the image representing the geographic atrophy region specified as described above is overlaid on the fundus image (or the tomographic image). Further, the display controller  111 A causes the plurality of layer thickness maps (two-dimensional distribution information of the layer thickness) in the fundus plane to be displayed in a second chronological image display region (second time-series image display region) AR 2  of the display apparatus  190  in chronological order. The plurality of layer thickness maps are generated by the layer thickness distribution information generator  205 . In some embodiments, the layer thickness map displayed in the second chronological image display region AR 2  is displayed to correspond to the atrophy region image displayed in the first chronological image display region AR 1 . For example, the layer thickness map and the atrophy region image on the same inspection date displayed so as to be vertically aligned. 
     Further, the display controller  111 A causes a trend graph GP 1  and a trend graph GP 2  to be displayed in an analysis result display region AR 3  of the display apparatus  190 . The trend graph GP 1  represents the temporal change in the total values of the areas of the specified geographic atrophy regions. The trend graph GP 2  represents the temporal change in the total values of the outer perimeters of the specified geographic atrophy regions. 
     In the trend graph GP 1 , the horizontal axis represents time (for example, the age of the subject), and the vertical axis represents the total value of the areas of all the specified geographic atrophy regions. In the trend graph GP 1 , regression straight lines of the total value are displayed. In some embodiments, the predicted value of the total value at a desired time is displayed in the trend graph GP 1 . In some embodiments, the scale of the horizontal axis of the trend graph GP 1  or the display start timing (the first inspection date on which a trend is displayed) of the trend graph GP 1  is designated by the user using the operating apparatus  180 . In some embodiments, when a plot value on the trend graph GP 1  is designated using the operating apparatus  180 , the atrophy region image or the layer thickness map corresponding to the designated plot value is highlighted. In some embodiments, when a plot value on the trend graph GP 2  is designated using the operating apparatus  180 , a plotted position on the trend graph GP 1  corresponding to the designated plot value is highlighted. 
     In the trend graph GP 2 , the horizontal axis represents time (for example, the age of the subject), and the vertical axis represents the total value of the outer perimeters of all the specified geographic atrophy regions. In the trend graph GP 2 , regression straight lines of the total value are displayed. In some embodiments, the predicted value of the total value at a desired time is displayed in the trend graph GP 2 . In some embodiments, the scale of the horizontal axis of the trend graph GP 2  or the display start timing (the first inspection date on which a trend is displayed) of the trend graph GP 2  is designated by the user using the operating apparatus  180 . In some embodiments, when a plot value on the trend graph GP 2  is designated using the operating apparatus  180 , the atrophy region image or the layer thickness map corresponding to the designated plot value is highlighted. In some embodiments, when a plot value on the trend graph GP 1  is designated using the operating apparatus  180 , a plotted position on the trend graph GP 2  corresponding to the designated plot value is highlighted. 
     In some embodiments, the changed contents of the display conditions (scale of horizontal axis, display start date) for the trend graph GP 1  are reflected in the display conditions for the trend graph GP 2  so as to be always displayed under the same display conditions. 
     The analyzer  200  according to some embodiments specifies the geographic atrophy region (designated atrophy region) designated by the user using the operating apparatus  180 . The display controller  111 A causes the specified geographic atrophy region to be displayed on the display apparatus  190  so as to be identifiable in at least one of the plurality of atrophy region images displayed in chronological order. 
     The display controller  111 A according to some embodiments causes the image (trend graph etc.) representing the temporal change in the morphology information in the geographic atrophy region designated by the user using the operating apparatus  180  to be displayed on the display apparatus  190 . 
     Modification Example 
     The configuration according to some embodiments is not limited to the above configuration. 
     First Modification Example 
     The relative position of the geographic atrophy region with respect to the macular region (fovea) is effective for the diagnosis of atrophic AMD. The ophthalmologic information processing apparatus according to a modification example of some embodiments analyzes the data of the fundus of the subject&#39;s eye acquired by the ophthalmologic apparatus to generate position information representing a position or a distance of the geographic atrophy region with respect to the macular region (fovea) on the fundus. 
     In the following, the ophthalmologic information processing apparatus according to the modification example of the embodiments will be described focusing on differences from the ophthalmologic information processing apparatus according to the above embodiments. The difference between the configuration of the ophthalmologic information processing apparatus according to the present modification example and the configuration of the ophthalmologic information processing apparatus  100  described above is the analyzer. 
       FIG. 16  shows a block diagram of an example of the configuration of the analyzer  200   a  according to the modification example of the embodiments. In  FIG. 16 , parts similar to those in  FIG. 4  are denoted by the same reference symbols, and description thereof is omitted as appropriate. 
     In the present modification example, an analyzer  200   a  according to the modification example shown in  FIG. 16  is provided instead of the analyzer  200  in the data processor  130  shown in  FIG. 3 . The analyzer  200   a  differs from the analyzer  200  in that a position information generator  206   a  is added to the analyzer  200 . 
     The analyzer  200   a  specifies a region corresponding to the fovea by analyzing three-dimensional OCT data of the subject&#39;s eye using a known method, and specifies a region having a predetermined radius around the fovea as the macular region. 
     The position information generator  206   a  generates the position information. The position information represents a relative position of a representative position of the geographic atrophy region with respect to a representative position of the macular region specified by the analyzer  200   a , position information representing a distance between both the representative positions, vector information indicating a movement direction or a movement distance of the representative position of the geographic atrophy region in a predetermined period, or vector information indicating a movement direction or a movement distance of the representative position of the geographic atrophy region with respect to the representative position of the macular region in a predetermined period. Examples of the representative position of the macular region include a position of the fovea, a position of the center of gravity of the macular region, the closest (or farthest) position to the geographic atrophy region in the outline of the macular region, and the like. Examples of the representative position of the geographic atrophy region include a center position of the geographic atrophy region, a position of the center of gravity of the geographic atrophy region, the closest (or farthest) position to the macular region (or the fovea) in the outline of the geographic atrophy region, and the like. The display controller  111 A according to the modification example of some embodiments causes the position information, which is generated by the position information generator  206   a , to be displayed on the display apparatus  190  in association with the geographic atrophy region corresponding to the position information. 
     The display controller  111 A according to some embodiments causes the image (trend graph of the position information) representing the temporal change in the position information to be displayed on the display apparatus  190 . 
       FIG. 17  shows an example of the analysis information displayed on the display apparatus  190  in the modification example of the embodiments. 
     For example, the display controller  111 A causes the image IMGX representing the geographic atrophy region and the image IMGZ representing the position (range) of the macular region specified by the analyzer  200   a  superimposed on the shadowgram (the front image of the fundus) IMG 2  to be displayed on the display apparatus  190 . The image IMGZ may be an image representing a position of the fovea. 
     Further, the display controller  111 A can cause the position information representing the relative position of the geographic atrophy region with respect to the macular region, in addition to the morphology information including the total value of the area(s) of the geographic atrophy region(s), the total value of the outer perimeter(s) of the geographic atrophy region(s), or the number of the geographic atrophy region(s) to be displayed on the display apparatus  190 . The display controller  111 A according to some embodiments causes the position information of each of the geographic atrophy regions to be displayed on the display apparatus  190  in association with the geographic atrophy region corresponding to the position information. Thereby, the position of each of the geographic atrophy regions can be observed in detail. 
       FIG. 18  shows another example of the analysis information displayed on the display apparatus  190  in the modification example of the embodiments. 
     For example, the display controller  111 A causes the image IMGY (image of B scan cross section) representing the geographic atrophy region and the image IMGZ 1  representing the position (range) of the macular region specified by the analyzer  200   a  superimposed on the B scan image IMG 3  of the fundus to be displayed on the display apparatus  190 . Thereby, the position of geographic atrophy region with respect of the macular region can be observed in the B scan image in detail. 
     Second Modification Example 
     The ophthalmologic information processing apparatus  100  according to some embodiments cause a difference from a atrophy region image as a reference of the one or more atrophy region images to be displayed on the display apparatus  190  so as to be identifiable. 
     In the following, the ophthalmologic information processing apparatus according to the modification example of the embodiments will be described focusing on differences from the ophthalmologic information processing apparatus according to the above embodiments. The difference between the configuration of the ophthalmologic information processing apparatus according to the present modification example and the configuration of the ophthalmologic information processing apparatus  100  described above is the analyzer. 
     The analyzer according to the present modification example performs difference specifying processing for specifying a difference from a reference image, the reference image being one of the plurality of atrophy region images, for at least one of the plurality of atrophy region images. The display controller according to the present modification example causes a region corresponding to the difference described above in the at least one atrophy region image described above to be displayed on the display apparatus  190  so as to be identifiable. In the modification example according to some embodiments, the reference image is an atrophy region image generated using the data of the fundus of the subject&#39;s eye acquired on the earliest inspection date. 
       FIG. 19  shows a flow chart of an operation example of the ophthalmologic information apparatus according to the present modification example. In  FIG. 19 , like reference numerals designate like parts as in  FIG. 5 , and the same description may not be repeated. In  FIG. 19 , as in  FIG. 5 , it is assumed that the three-dimensional OCT data of the subject&#39;s eye acquired by the ophthalmologic apparatus has already stored in the ophthalmologic information processing apparatus (storage unit  112 ). 
     Steps S 1  to S 9  are the same as those in  FIG. 5 . 
     (S 31 : Acquire Analysis Data) 
     When it is determined that the trend analysis is to be performed in step S 9  (S 9 : Y), the controller  110  reads out one or more analysis data (including the atrophy region image) for performing trend analysis from the storage unit  112 . In step S 31 , the controller  110  controls the analyzer  200  to perform trend analysis processing, as in step S 10 . Further, as in step S 10 , in case that a predetermined analysis processing result of the data of the subject&#39;s eye is not obtained, the specification of the geographic atrophy region in step S 6  and the morphology analysis in step S 7  may be performed as necessary. For example, the analyzer  200  specifies a geographic atrophy region, or generates a trend graph of the area of the geographic atrophy region or a trend graph of the outer perimeter of the geographic atrophy region. 
     (S 32 : Specify Difference from Reference Image) 
     Next, the controller  110  specifies, as the reference image, the atrophy region image in which an image, which represents the geographic atrophy region specified using the data of the fundus of the subject&#39;s eye acquired on the earliest inspection date, is overlaid on the fundus image or the tomographic image. The controller  110  controls the analyzer to perform difference specifying processing on the atrophy region image included in the analysis data acquired in step S 31  with respect to the reference image. 
     (S 33 : Next Analysis Data?) 
     When there is next analysis data to be performed (S 33 : Y), the operation the ophthalmologic information processing apparatus  100  proceeds to step S 31 . When there is not next analysis data to be performed (S 33 : N), the operation of the ophthalmologic information processing apparatus  100  proceeds to step S 34 . 
     In the modification example according to some embodiments, in step S 32 , the atrophy region image acquired immediately before the atrophy region image of the difference specifying processing target in step S 31  is set as the reference image. Thereby, the analyzer can subsequently perform difference specifying processing described above on the plurality of atrophy region images by specifying the difference of the atrophy region images using the atrophy region image obtained immediately before the reference image. 
     (S 34 : Perform Identification Processing on Difference Region) 
     When there is not next analysis data to be performed (S 33 : N), the controller  110  controls the data processor or the like to perform identification processing on a difference region specified in step S 32 . For example, in order that the difference region is displayed so as to be identifiable, the data processor changes image data corresponding to the difference region so as to change the pixel value of the difference region. 
     (S 35 : Display in Chronological Order) 
     The display controller  111 A causes the plurality of atrophy region images to be displayed in a predetermined display region of the display apparatus  190  in chronological order (in time series). In each of the plurality of atrophy region images, the image representing the geographic atrophy region, on which the identification processing is performed on the difference region in step S 34 , is overlaid on the fundus image or the tomographic image. Further, the display controller  111 A causes the plurality of two-dimensional distribution information of the layer thickness in the fundus plane generated by the layer thickness distribution information generator  205  to be displayed in a predetermined display region of the display apparatus  190  in chronological order. 
     (S 36 : Display Trend Graph) 
     The display controller  111 A causes the trend graph generated in step S 10  to be displayed in the predetermined display region of the display apparatus  190 . This terminates the operation of the ophthalmologic information processing apparatus  100  (END). 
       FIG. 20  shows an example of the atrophy region image according to the modification of some embodiments. In  FIG. 20 , parts similar to those in  FIG. 13  are denoted by the same reference symbols, and description thereof is omitted as appropriate. 
     For example, the display controller  111 A causes the image IMGX 1  representing the geographic atrophy region superimposed on the shadowgram (the front image of the fundus) IMG 2  to be displayed on the display apparatus  190 . In the image IMGX 1  representing the geographic atrophy region, the difference region IMGW with reference to the reference image is depicted so as to be identifiable. 
     Further, the display controller  111 A can cause the morphology information  350  including the total value of the area(s) of the geographic atrophy region(s), the total value of the outer perimeter(s) of the geographic atrophy region(s), and the number of the geographic atrophy region(s) to be displayed on the display apparatus  190 . The display controller  111 A according to some embodiments causes the morphology information of each of the geographic atrophy regions to be displayed on the display apparatus  190  in association with the geographic atrophy region corresponding to the morphology information. Thereby, the morphology of each of the geographic atrophy regions can be observed in detail. Further, the shape of the difference region with reference to the reference image can be grasped in detail. 
     Third Modification Example 
     The ophthalmologic apparatus according to some embodiments has at least one of the function of the ophthalmologic information processing apparatus  100 , the function of the operating apparatus  180 , and the function of the display apparatus  190 , in addition to the function of the ophthalmologic apparatus  10 . 
     In the following, the ophthalmologic apparatus according to a modification example of some embodiments will be described focusing on differences from the ophthalmologic apparatus according to the above embodiments. 
       FIG. 21  shows a block diagram of an example of the configuration of the ophthalmologic apparatus  10   b  according to the modification example of the embodiments. In  FIG. 21 , components similar to those in  FIG. 2  are given the same reference numerals. The description of such components is basically omitted. 
     The difference between the configuration of the ophthalmologic apparatus  10   b  according to the present modification example and the configuration of ophthalmologic apparatus  10  according to the above embodiments is that the ophthalmologic apparatus  10   b  has the function of the ophthalmologic information processing apparatus  100 , the function of the operating apparatus  180 , and the function of the display apparatus  190 . The ophthalmologic apparatus  10   b  includes a controller  11   b , the data acquisition unit  12 , the image forming unit  13 , an ophthalmologic information processor  15   b , an operating unit  16   b , and a display unit  17   b.    
     The controller  11   b  controls each part of the ophthalmologic apparatus  10   b . In particular, the controller  11   b  controls the data acquisition unit  12 , the image forming unit  13 , the ophthalmologic information processor  15   b , the operating unit  16   b , and the display unit  17   b.    
     The ophthalmologic information processor  15   b  has the same configuration as the ophthalmologic information processing apparatus  100 , and has the same function as the ophthalmologic information processing apparatus  100 . The operating unit  16   b  has the same configuration as the operating apparatus  180 , and has the same function as the operating apparatus  180 . The display unit  17   b  has the same configuration as the display apparatus  190 , and has the same function as the display apparatus  190 . 
     According to the present modification example, an ophthalmologic apparatus capable of observing in detail the morphology and the distribution of the geographic atrophy region in a compact configuration can be provided. 
     Effects 
     Hereinafter, the effects of the ophthalmologic information processing apparatus, the ophthalmologic system, the ophthalmologic information processing method, and the program according to some embodiments will be described. 
     An ophthalmologic information processing apparatus ( 100 ) according to some embodiments includes an analyzer ( 200 ,  200   a ), and a display controller ( 111 A). The analyzer is configured to specify one or more atrophy regions (geographic atrophy regions) in a fundus of a subject&#39;s eye by analyzing data of the fundus acquired using optical coherence tomography. The display controller is configured to cause a plurality of images, each of which represents the one or more atrophy regions specified by the analyzer, to be displayed on a display means (display apparatus  190 ) in chronological order, based on the plurality of data acquired at different timings. 
     According to such a configuration, the plurality of images representing the one or more atrophy regions specified based on the plurality of data of the fundus acquired at different timings, is displayed on the display means in chronological order. Thereby, the morphology or the distribution of the atrophy region such as a geographic atrophy region can be easily performed follow-up observation. 
     The ophthalmologic information processing apparatus according to some embodiments includes a position matching processor ( 210 ). The position matching processor is configured to perform position matching between a fundus image of the subject&#39;s eye and the image representing the one or more atrophy regions. The display controller is configured to cause a plurality of atrophy region images, in each of which the image representing the one or more atrophy regions, which has been performed position matching by the position matching processor, is overlaid on the fundus image, to be displayed on the display means in chronological order. 
     According to such a configuration, the plurality of the atrophy region images, in each of which the image representing the atrophy region such as a geographic atrophy region is overlaid on the fundus image, is displayed on the display means in chronological order. Thereby, the morphology or the distribution of the atrophy region on the fundus can be easily performed follow-up observation, and accurate diagnosis of the atrophic AMD can be assisted. 
     In the ophthalmologic information processing apparatus according to some embodiments, the analyzer is configured to perform difference specifying processing for specifying a difference from a reference image, the reference image being one of the plurality of atrophy region images, for at least one of the plurality of atrophy region images. The display controller is configured to cause a region corresponding to the specified difference as described above in the at least one atrophy region image to be displayed on the display means so as to be identifiable. 
     According to such a configuration, the difference with reference to the reference image is displayed on the display means so as to be identifiable in the atrophy region image. Therefore, change in the morphology or the distribution of the atrophy region can be easily grasped. Thereby, an accurate diagnosis of atrophic AMD can be assisted. 
     In the ophthalmologic information processing apparatus according to some embodiments, the analyzer is configured to sequentially perform the difference specifying processing on the plurality of atrophy region images by specifying the difference of the atrophy region images using the atrophy region image obtained immediately before as the reference image. 
     According to such a configuration, the difference from the atrophy region image obtained immediately before is displayed on the display means so as to be identifiable in the plurality of atrophy region images. Therefore, change in the morphology or the distribution of the atrophy region can be easily grasped. Thereby, an accurate diagnosis of atrophic AMD can be assisted. 
     In the ophthalmologic information processing apparatus according to some embodiments, the analyzer is configured to specify a position of a macular region in the fundus based on the data of the fundus described above. The display controller is configured to cause an image representing the position of the macular region specified by the analyzer to be overlaid and displayed on the atrophy region image. 
     According to such a configuration, the progress of the atrophy AMD can be easily grasped. Thereby, an accurate diagnosis of progressive atrophic AMD can be assisted. 
     In the ophthalmologic information processing apparatus according to some embodiments, the analyzer includes a segmentation processor ( 201 ) and a distribution information generator ( 203 ). The segmentation processor is configured to specify a plurality of layer regions in an A scan direction based on data of the fundus described above. The distribution information generator is configured to generate distribution information on ratio (contrast map) between integrated values of pixel values in the A scan direction of the layer regions located on a sclera side with reference to a Bruch membrane and integrated values of pixel values in the A scan direction of the layer regions located on a cornea side with reference to the Bruch membrane, the layer regions being specified by the segmentation processor. The analyzer is configured to specify the atrophy region based on the distribution information. 
     According to such a configuration, the atrophy region such as a geographic atrophy region is specified from the data acquired using optical coherence tomography and the image of the specified atrophy region is displayed on the display means in chronological order. Thereby, the morphology or the distribution of the atrophy region such as a geographic atrophy region can be easily performed follow-up observation while reducing the burden on the subject. 
     In the ophthalmologic information processing apparatus according to some embodiments, the analyzer includes a morphology information generator ( 204 ). The morphology information generator is configured to generate morphology information representing morphology of the atrophy region by analyzing the data of the fundus described above. The display controller is configured to cause a plurality of the morphology information to be displayed on the display means in chronological order. 
     According to such a configuration, the morphology or the distribution of the atrophy region such as a geographic atrophy region can be easily performed follow-up observation, and the morphology of the atrophy region can be observed in detail. The display controller may cause the morphology information to be displayed on the display means in association with the atrophy region corresponding to the morphology information. 
     In the ophthalmologic information processing apparatus according to some embodiments, the morphology information includes at least one of an area of the atrophy region, and an outer perimeter of the atrophy region. 
     According to such a configuration, the temporal change in the area or the outer perimeter of the atrophy region is displayed. Thereby, the morphology or the distribution of the atrophy region can be easily performed follow-up observation in detail. 
     In the ophthalmologic information processing apparatus according to some embodiments, the display controller is configured to cause at least one of the area of the atrophy region and the outer perimeter of the atrophy region to be displayed on the display means in chronological order for each of the plurality of atrophy regions specified by the analyzer. 
     According to such a configuration, the morphology or the distribution of each of the atrophy regions such as geographic atrophy regions can be easily performed follow-up observation, and the morphology of the atrophy region can be observed in detail. 
     In the ophthalmologic information processing apparatus according to some embodiments, the morphology information includes a total value of the areas of the one or more atrophy regions specified by the analyzer or a total value of the outer perimeters of the one or more atrophy regions specified by the analyzer. 
     According to such a configuration, the morphology or the distribution of the atrophy region can be quantitatively performed follow-up observation and can be observed in detail. 
     In the ophthalmologic information processing apparatus according to some embodiments, the morphology information includes number of the atrophy regions. 
     According to such a configuration, the morphology or the distribution of the atrophy region can be quantitatively performed follow-up observation and can be observed in detail. 
     In the ophthalmologic information processing apparatus according to some embodiments, the display controller is configured to cause an image representing temporal change in the morphology information generated based on a plurality of the morphology information to be displayed on the display means. 
     According to such a configuration, the morphology or the distribution of the atrophy region such as a geographic atrophy region can be easily performed follow-up observation, and the morphology of the atrophy region can be observed in detail. 
     The ophthalmologic information processing apparatus according to some embodiments includes a designating unit (operating apparatus  180 ). The designating unit is used for designating the atrophy region specified by the analyzer. The display controller is configured to cause an image representing temporal change in the morphology information in the atrophy region designated by the designating unit to be displayed on the display means. 
     According to such a configuration, the temporal change in the morphology information on the atrophy region designated by the designating unit can be easily grasped. Thereby, an accurate diagnosis of the atrophy region of interest can be assisted. 
     In the ophthalmologic information processing apparatus according to some embodiments, the analyzer includes a position information generator ( 206   a ). The position information generator is configured to generate position information representing a position or a distance of the atrophy region with respect to a macular region in the fundus by analyzing the data of the fundus described above. The display controller is configured to cause an image representing temporal change in the position information generated based on a plurality of the position information to be displayed on the display means. 
     According such a configuration, the change in positional relationship between the macular region and the atrophy region can be easily grasped. 
     The ophthalmologic information processing apparatus according to some embodiments includes a designating unit (operating apparatus  180 ). The designating unit is used for designating the atrophy region specified by the analyzer. The analyzer is configured to specify a region corresponding to a designated atrophy region which is designated among the plurality of images, each of which represents the one or more atrophy regions, by the designating unit. The display controller is configured to cause the designated atrophy region to be displayed on the display means so as to be identifiable in at least one of the plurality of images, each of which represents the one or more atrophy regions. 
     According to such a configuration, alone the atrophy region(s) designated using the designating unit can be displayed so as to be identifiable in the plurality of atrophy region images. Thereby, while focusing on a desired atrophy region, the change in the morphology or the distribution can be grasped. 
     The ophthalmologic information processing apparatus according to some embodiments includes a layer thickness distribution generator ( 205 ). The layer thickness distribution information generator is configured to specify a layer thickness of one or more layer tissues in an A scan direction based on the data of the fundus described above, and to generate distribution information of the specified layer thickness. The display controller is configured to cause the distribution information of the layer thickness generated by the layer thickness distribution information generator to be displayed on the display means in chronological order. 
     According to such a configuration, the distribution of the layer thickness in the fundus can be easily performed follow-up observation, and the change in the distribution of the layer thickness can be observed in detail. 
     An ophthalmologic system according to some embodiments includes a data acquisition unit ( 12 ) configured to acquire the data of the fundus described above by scanning the subject&#39;s eye using optical coherence tomography, the display means, and the ophthalmologic information processing apparatus described in any one of the above. 
     According to such a configuration, the plurality of images representing the one or more atrophy regions specified based on the plurality of data of the fundus acquired at different timings, is displayed on the display means in chronological order. Thereby, the ophthalmologic system capable of easily performing follow-up observation for the morphology or the distribution of the atrophy region such as a geographic atrophy region can be provided. 
     An ophthalmologic information processing method includes an analysis step and a display step. The analysis step is performed to specify one or more atrophy regions in a fundus of a subject&#39;s eye by analyzing data of the fundus acquired using optical coherence tomography. The display step is performed to cause a plurality of images, each of which represents the one or more atrophy regions specified in analysis step, to be displayed on a display means (display apparatus  190 ) in chronological order, based on the plurality of data acquired at different timings. 
     According to such a configuration, the plurality of images representing the one or more atrophy regions specified based on the plurality of data of the fundus acquired at different timings, is displayed on the display means in chronological order. Thereby, the morphology or the distribution of the atrophy region such as a geographic atrophy region can be easily performed follow-up observation. 
     The ophthalmologic information processing method according to some embodiments includes a position matching step. The position matching step is performed to perform position matching between a fundus image of the subject&#39;s eye and the image representing the one or more atrophy regions. The display step is performed to cause a plurality of atrophy region images, in each of which the image representing the one or more atrophy regions, which has been performed position matching in the position matching step, is overlaid on the fundus image, to be displayed on the display means in chronological order. 
     According to such a configuration, the plurality of the atrophy region images, in each of which the image representing the atrophy region such as a geographic atrophy region is overlaid on the fundus image, is displayed on the display means in chronological order. Thereby, the morphology or the distribution of the atrophy region on the fundus can be easily performed follow-up observation, and accurate diagnosis of the atrophic AMD can be assisted. 
     In the ophthalmologic information processing method according to some embodiments, the analysis step includes a segmentation processing step and a distribution information generating step. The segmentation processing step is performed to specify a plurality of layer regions in an A scan direction based on the data of the fundus describe above. The distribution information generating step is performed to generate distribution information on ratio (contrast map) between integrated values of pixel values in the A scan direction of the layer regions located on a sclera side with reference to a Bruch membrane and integrated values of pixel values in the A scan direction of the layer regions located on a cornea side with reference to the Bruch membrane, the layer regions being specified in the segmentation processing step. The analysis step is performed to specify the atrophy region based on the distribution information. 
     According to such a configuration, the atrophy region such as a geographic atrophy region is specified from the data acquired using optical coherence tomography and the image of the specified atrophy region is displayed on the display means in chronological order. Thereby, the morphology or the distribution of the atrophy region such as a geographic atrophy region can be easily performed follow-up observation while reducing the burden on the subject. 
     In the ophthalmologic information processing method according to some embodiments, the analysis step is performed to generate morphology information representing morphology of the atrophy region by analyzing the data of the fundus described above. The display step is performed to cause an image representing temporal change in the morphology information generated based on a plurality of the morphology information to be displayed on the display means. 
     According to such a configuration, the morphology or the distribution of the atrophy region such as a geographic atrophy region can be easily performed follow-up observation, and the morphology of the atrophy region can be observed in detail. 
     A program according to some embodiments causes a computer to execute each step of the ophthalmologic information processing method described in any of the above. 
     According to such a configuration, the computer causes the plurality of images, each of which represents the one or more atrophy regions specified based on the plurality of data of the fundus acquired at different timing, to be displayed on the display means in chronological order. Thereby, the program for easily performing follow-up observation for the morphology or the distribution of the atrophy region such as a geographic atrophy region can be provided. 
     A program for realizing the ophthalmologic information processing method according to some embodiments can be stored in any kind of computer non-transitory recording medium. The recording medium may be an electronic medium using magnetism, light, magneto-optical, semiconductor, or the like. Typically, the recording medium is a magnetic tape, a magnetic disk, an optical disk, a magneto-optical disk, a flash memory, a solid state drive, or the like. 
     The computer program may be transmitted and received through a network such as the Internet, LAN, etc. 
     Configurations described above are merely examples for preferably implementing the present invention. One who intends to implement the present invention may arbitrarily modify (omission, replacement, addition, etc.) within the scope of the invention. 
     The invention has been described in detail with particular reference to preferred embodiments thereof and examples, but it will be understood that variations and modifications can be effected within the spirit and scope of the invention covered by the claims which may include the phrase “at least one of A, B and C” as an alternative expression that means one or more of A, B and C may be used, contrary to the holding in Superguide v. DIRECTV, 69 USPQ2d 1865 (Fed. Cir. 2004). 
     While certain embodiments have been described, these embodiments have been presented by way of example only, and are not intended to limit the scope of the inventions. Indeed, the novel embodiments described herein may be embodied in a variety of other forms; furthermore, various omissions, substitutions and changes in the form of the embodiments described herein may be made without departing from the spirit of the inventions. The accompanying claims and their equivalents are intended to cover such forms or modifications as would fall within the scope and spirit of the inventions.