Patent Publication Number: US-2012041376-A1

Title: Catheter, catheter fixture, catheter kit and catheter manufacturing method

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     This application is a continuation of PCT international application Ser. No. PCT/JP2010/057098 filed on Apr. 21, 2010 which designates the United States, incorporated herein by reference, and which claims the benefit of priority from Japanese Patent Application No. 2009-104530, filed on Apr. 22, 2009, incorporated herein by reference. 
    
    
     BACKGROUND OF THE INVENTION 
     1. Field of the Invention 
     The present invention relates to a catheter inserted inside the body of mammals including human beings, a catheter fixture, a catheter kit and a catheter manufacturing method. 
     2. Description of the Related Art 
     Conventionally, a catheter is inserted into the body of a mammal including human beings to, for example, administer a drug inside the body utilizing this catheter. In this case, the elongated tubular catheter is moved in its axial direction and inserted in tissues of the body (see, for example, Japanese National Publication of International Patent Application No. 2003-504132). 
     SUMMARY OF THE INVENTION 
     A catheter kit according to an aspect of the present invention includes an elongated tubular catheter having at least one drug discharge hole in a side of the catheter, the catheter having a first engaging structure in a distal end part closer to a distal end side than the drug discharge hole; and a catheter fixture that is separated from the catheter, the catheter fixture having a second engaging structure that engages with the first engaging structure, the catheter fixture being fixed to the distal end part of the catheter with when the first engaging structure and the second engaging structure engage, the catheter fixture being wider than a diameter of the catheter in a direction perpendicular to an axis of the catheter in a fixed state. 
     A catheter kit according to another aspect of the present invention includes an elongated tubular catheter having at least one drug discharge hole in a side, having a first engaging structure in a distal end part closer to a distal end side than the drug discharge hole, and having a first flange that is a flange provided in a position closer to a proximal end side than a position of the drug discharge hole; and a catheter fixture that is separated from the catheter, the catheter fixture having a second engaging structure that engages with the first engaging structure, and having a second flange that is a flange provided in a position closer to the distal end side than a position of the drug discharge hole. 
     A method according to still another aspect of the present invention is for manufacturing a catheter to be inserted in an organ to administer a drug to a drug administration target inside the organ, and includes acquiring positions of the organ and the drug administration target using an in-vivo observation device; determining an insertion route of the catheter to the organ, based on the acquired positions of the organ and the drug administration target; and forming a drug discharge hole in a side of the catheter which meets the drug administration target, based on the positions of the organ and the drug administration target and the determined insertion route. 
     The above and other features, advantages and technical and industrial significance of this invention will be better understood by reading the following detailed description of presently preferred embodiments of the invention, when considered in connection with the accompanying drawings. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  is a schematic view schematically illustrating an organ and a tumor to which a catheter according to a first embodiment of the present invention is inserted; 
         FIG. 2  is a view illustrating a manufacturing process of a catheter according to the first embodiment of the present invention; 
         FIG. 3  is a view illustrating an example of a preparation process of a catheter illustrated in  FIG. 2 ; 
         FIG. 4  is an explanatory view illustrating that a catheter is fixed to an organ by means of a catheter and catheter fixture according to the first embodiment of the present invention; 
         FIG. 5  is a view illustrating an example of separation process of a catheter and catheter fixture fixed to an organ; 
         FIG. 6  is a schematic view illustrating a separating position of a catheter and catheter fixture according to the first embodiment of the present invention; 
         FIG. 7  is a view illustrating a configuration of a catheter fixture according to a second embodiment of the present invention; 
         FIG. 8  is a schematic view illustrating a separating position of a catheter and catheter fixture according to the second embodiment of the present invention; 
         FIG. 9  is a perspective view illustrating a configuration of a catheter fixture according to a third embodiment of the present invention; 
         FIG. 10  is a perspective view illustrating a configuration of a catheter fixture according to a modification of the third embodiment of the present invention; 
         FIG. 11  is a schematic view illustrating a configuration and fixing process of a catheter and catheter fixture according to a fourth embodiment of the present invention; 
         FIG. 12  is a schematic view illustrating a configuration of a gripping part according to a first modification of the fourth embodiment of the present invention; 
         FIG. 13  is a schematic view illustrating a configuration of a gripping part according to a second modification of the fourth embodiment of the present invention; 
         FIG. 14  is a schematic view illustrating a configuration and fixing process of a catheter and catheter fixture according to a fifth embodiment of the present invention; 
         FIG. 15  is a schematic view illustrating a configuration of a catheter and catheter fixture according to a sixth embodiment of the present invention; 
         FIG. 16  is a schematic view illustrating a configuration of a catheter and catheter fixture according to a modification of the sixth embodiment of the present invention; 
         FIG. 17  is a schematic view illustrating a configuration and fixing process of a catheter and catheter fixture according to a seventh embodiment of the present invention; 
         FIG. 18  is a schematic view illustrating a configuration of a catheter according to a modification of the seventh embodiment of the present invention; 
         FIG. 19  is a schematic view illustrating a configuration and fixing process of a catheter and catheter fixture according to an eighth embodiment of the present invention; and 
         FIG. 20  is a schematic view illustrating a configuration of a catheter and catheter fixture according to a ninth embodiment of the present invention. 
     
    
    
     DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS 
     Hereinafter, a catheter, a catheter fixture, a catheter kit and a catheter manufacturing method according to embodiments of the present invention will be described with reference to the drawings. 
     First Embodiment 
     First, a catheter and a catheter manufacturing method will be described with reference to  FIG. 1  to  FIG. 3 .  FIG. 1  illustrates a state where there is a tumor  2  of a drug administration target inside an organ  1  of the body. Meanwhile, an operator acquires shapes and positions of the organ  1  and tumor  2  using an in-vivo observation device C 1  such as an MRI, CT, roentgen device or ultrasonic detector. 
     Then, the operator specifies an insertion route  3  for administering a drug to the tumor  2  based on the shapes and positions of the organ  1  and tumor output on a display device C 2  connected to the in-vivo observation device C 1 . This insertion route  3  may be specified automatically using a processing device C 3  connected to the in-vivo observation device C 1 , or may be specified arbitrarily on a display screen according to an operation of the display device C 2  by the operator. 
     Then, the processing device C 3  calculates a parameter showing relative positions of the organ  1  and tumor  2  along the insertion route  3 , based on the specified insertion route  3 . For example, a distance La between a projecting position  4  of the catheter from the organ  1  and a projecting position  6  of the catheter from the tumor  2 , a distance Lb between the projecting position  4  of the catheter from the organ  1  and an insertion position  7  of the catheter to the tumor  2  and a distance Lc between the projecting position  4  of the catheter from the organ  1  and an insertion position  5  of the catheter to the organ  1  are calculated. In addition, these parameters may be calculated by the operator depending on display content on the display screen of the display device C 2 . 
     Meanwhile, as illustrated in ( 1 ) of  FIG. 2 , a catheter body  8  has an elongated, cylindrical shape having a sharp tip  10 , and an internal passage  9  in which, for example, a drug flows. Further, a penetration hole  11  which is a first engaging structure is provided at a distal end part  12 . In addition, as illustrated in  FIG. 3 , with the catheter body  8 , mark lines  14  and scales  15  which serve as an indication for a punching operation are provided in a punching area  13  in which drug discharge holes will be formed. Further, a mark M 1  is provided on a proximal end side of the distal end part  12 , and serves as an indication upon an operation of separating only the distal end part  12 . 
     As illustrated in ( 1 ) of  FIG. 2 , with the catheter body  8  in which the penetration hole  11  and internal passage  9  are formed, one or a plurality of drug discharge holes  16  are punched in the side of the catheter body  8  as illustrated in ( 2 ) of  FIG. 2  based on the above parameters to manufacture a catheter suitable for the organ  1  and tumor  2  for which the positional relationship along the insertion route  3  is learned. With this punching, while a tube wall is penetrated in front of the catheter body  8  using, for example, a reamer, the tube wall ahead of the internal passage  9  is not penetrated. In this case, the drug discharge holes  16  are positioned using the mark lines  14  and scales  15  illustrated in  FIG. 3 . In addition, when the catheter is inserted and positioned in the organ  1 , the positions of the drug discharge holes  16  are determined such that the drug discharge holes  16  are positioned inside the tumor  2 . 
     In ( 2 ) of  FIG. 2 , three drug discharge holes  16  are punched in the side of the catheter body  8 . That is, the inner wall of the penetration hole  11  at the catheter distal end on the proximal end side meets the projecting position  4  of the catheter from the organ  1 , a distal end rim of the drug discharge hole closest to the distal end side meets the projecting position  6  of the catheter from the tumor  2 , and the proximal end rim of the drug discharge hole closest to the proximal end side meets the insertion position  7  of the catheter to the tumor  2 . Further, the distance La illustrated in  FIG. 1  is equal to a distance La′ between the inner wall of the penetration hole  11  of the catheter distal end on the proximal end side and the distal end rim of the drug discharge hole closest to the distal end side. Further, the distance Lb illustrated in  FIG. 1  is equal to a distance Lb′ between the inner wall of the penetration hole  11  of the catheter distal end on the proximal end side and the proximal end rim of the drug discharge hole closest to the proximal end side. That is, based on La=La′ and Lb=Lb′, the positions of the drug discharge holes  16  are within the range of Lb′-La′. By providing the drug discharge holes  16  within the range of this Lb′-La′, the drug discharge holes  16  are positioned inside the tumor  2 . 
     In addition, taking deformation or a margin of the organ  1  into account, the relationships of La=La′ and Lb=Lb′ may be intentionally changed. Further, the positions of the drug administration holes  16  vary depending on a treatment policy of, for example, concentrating administration of a drug on the center of the tumor  2 . In any case, the drug discharge holes  16  are formed in positions from which a drug is administered inside the tumor  2 , based on the above parameters. 
     Then, the operator fixes a flange  18  to the catheter body  8 . In a state where the catheter is inserted in the organ  1 , this flange  18  abuts on the surface of the organ  1  at the insertion position, and, upon this abuttal, all drug discharge holes  16  need to be positioned inside the tumor  2 . Hence, the flange  18  abuts on the organ  1  at a position at which all drug discharge holes  16  are positioned inside the tumor  2 . In this case, the fixing position of the flange  18  is closer to the proximal end side than the drug discharge hole  16  closest to the proximal end side among the drug discharge holes  16  formed in the catheter body  8 . 
     More specifically, as illustrated in ( 3 ) of  FIG. 2 , a ring-shaped flange fixing member  17  for fixing the flange  18  to the catheter body  8  is first inserted from the catheter distal end side. The flange fixing member  17  after the insertion is adhered and fixed to the proximal end side of the catheter to function as a stopper at a position at which the flange  18  is positioned (see ( 4 ) of  FIG. 2 ). Further, as illustrated in ( 4 ) of  FIG. 2 , the flange  18  is inserted in the catheter body  8  from the distal end side of the catheter, and is adhered and fixed to the flange fixing member  17 . By this means, as illustrated in ( 5 ) of  FIG. 2 , a catheter  19  having the catheter body  8  and flange  18  is formed. 
     Meanwhile, a distance Lc′ between the inner wall of the penetration hole  11  of the catheter distal end part on the proximal end side and the surface of the flange  18  on the distal end side (abutting surface with respect to the organ  1 ) is equal to the distance Lc illustrated in  FIG. 1 . By this means, by inserting the catheter  19  until the flange  18  abuts on the organ  1 , it is possible to position all drug discharge holes  16  inside the tumor  2 . 
     Although the catheter  19  can be manufactured like a custom-made catheter in this way, this is not the case when the catheters  19  are mass-produced according to the specification set in advance. Meanwhile, the catheter  19  has the drug administration holes  16  and flange  18  in the catheter body  8  as described above. 
     In addition, the catheter  19  is preferably sterilized. 
     The catheter  19  manufactured in this way is inserted in the organ  1  along the insertion route  3  illustrated in  FIG. 1 . The distal end part of the catheter  19  projecting from this organ  1  is fixed by a catheter fixture  20 . 
     As illustrated in ( 1 ) of  FIG. 4 , the catheter fixture  20  has a slide bar  21  and a slider  23  which are base members. The slide bar  21  has a penetration hole  22  having a size which allows the distal end part  12  of the catheter  19  to pass therethrough. By contrast with this, the slider  23  has a shape bent in a nearly L-shape, and has in a lateral portion of the L-shape a penetration hole  28  through which the slide bar  21  penetrates. The slider  23  can move in the axial direction of the slide bar  21  through the penetration hole  28 . A lock bar  24  is provided to stand near the penetration hole  28 , an engaging groove  26  which is a second engaging structure engaging with the first engaging structure is formed on the upper part of the lock bar  24 , and an elastic ball  25  is provided at the distal end of the engaging groove  26 . Further, in the vertical portion of the L-shape, a protecting part  27  is formed which prevents the tip  10  of the catheter  19  from damaging other organs and tissues. 
     Further, positioning of the catheter  19  and catheter fixture  20  will be described with reference to  FIG. 4 . As illustrated in ( 2 ) of  FIG. 4 , when the catheter  19  is inserted until the flange  18  of the catheter  19  abuts on the surface of the organ  1 , the catheter  19  penetrates the organ  1  and tumor  2  and the distal end part  12  projects on the opposite side of the organ  1 . Hereinafter, the catheter fixture  20  is positioned in a position at which the distal end part  12  of the catheter  19  passes the penetration hole  22  of the slide bar  21 , and the distal end part  12  penetrates the penetration hole  22 . Then, when the slider  23  is moved upward along the axis of the slide bar  21 , as illustrated in ( 3 ) of  FIG. 4 , the front end portion of the lock bar  24  is inserted in the penetration hole  11  and the elastic ball  25  has a greater diameter than the penetration hole  11  and elastically deforms and passes the penetration hole  11 . As a result, the engaging groove  26  engages and positions the lock bar  24  and catheter  19 , respectively. Further, the catheter  19  and catheter fixture  20  are fixed fast across the organ  1 . 
     Meanwhile, the positional relationship of the catheter  19  and organ  1  is determined by the catheter fixture  20  on the distal end side, and is determined by the flange  18  on the proximal end side. Consequently, the relative positional relationship of the catheter  19  and organ  1  is fixed by the catheter fixture  20  and flange  18 , and the catheter  19  is not misaligned in the axial direction with respect to the organ  1 . 
     Then, when administration of a drug is finished through the catheter  19 , the operator removes the catheter  19  and catheter fixture  20  to the outside of the body. That is, as illustrated in ( 1 ) of  FIG. 5 , for example, the catheter is cut at a mark M 1  portion which serves as an indication of the mark M 1  formed between the distal end part  12  of the catheter  19  and punching area  13 . Further, as illustrated in ( 2 ) of  FIG. 5 , a catheter  19   a  from which the distal end part  12  is separated off is pulled out from the organ  1 . Further, as illustrated in ( 3 ) of  FIG. 5 , a catheter fixture  20   a  engaged with the distal end part  12  is pulled out. 
     In addition, the separating position is not limited to the position of the mark M 1 , and the catheter may be separated at a position P 2  on the organ  1  side of the flange  18  as illustrated in  FIG. 6 . 
     Second Embodiment 
     Next, a second embodiment of the present invention will be described with reference to  FIG. 7 . As illustrated in ( 1 ) of  FIG. 7 , with this second embodiment, a catheter fixture  30  is formed by further providing a flange  31  to the above catheter fixture  20  on the organ  1  side. Although, with the first embodiment, the slide bar  21  has a function of a flange on the distal end side with respect to the organ  1 , even when this slide bar  21  is not arranged near the organ  1  side, it is possible to reliably fix the catheter  19  to the organ  1  by providing a dedicated flange  31  on the organ  1  side. This flange  31  is provided with a penetration hole  32  through which the catheter  19  projecting from the organ  1  passes, and the catheter  19  passes this penetration hole  32  and penetration hole  22 . In this case, when the flange  31  is provided, the positions of the drug discharge holes  16  on the catheter  19  need to be changed. In ( 2 ) of  FIG. 7 , illustrated is a mode of use of the catheter fixture  30  according to the second embodiment. 
       FIG. 8  is a view describing a separating position of the catheter  19  and catheter fixture  30  according to this second embodiment. As illustrated in  FIG. 8 , the catheter can be separated at the position of the mark M 1  similar to the first embodiment. Further, it is possible to separate the catheter at a position P 13  on the organ  1  side of the flange  18 . In addition, the catheter may be separated at a position P 12  on the distal end side of the penetration hole  32  of the flange  31  or at a position P 11  on the proximal end side of the penetration hole  22  of the slide bar  20 . When the catheter  19  is removed, if the catheter is separated at the position P 11 , the distance which the catheter  19  passes through the organ  1  is the distance L 2  and is greater than the distance L 1  illustrated in  FIG. 6 , and therefore the catheter is preferably separated at the positions P 12 , P 13  or the position of the mark M 1  to reduce invasion. 
     Third Embodiment 
     Next, a third embodiment of the present invention will be described. With the third embodiment, engagement of the first engaging structure and second engaging structure can be manipulated from the outside of the body.  FIG. 9  is a perspective view illustrating a configuration of a catheter fixture according to the third embodiment of the present invention. Although a catheter fixture  40  illustrated in  FIG. 9  has a slider  41  having a shape bent in a nearly L-shape similar to the catheter fixture  20 , with this slider  41 , a cylindrical cap  41   a  into which a tube  42  is inserted is formed in the lateral portion of the L-shape. In the tube  42 , a wire  43  which extends from the cap  41   a  to the outside of the body is inserted. A latch part  44  at the tip of the wire  43  is embedded in the bottom of the tube  41   a  and latched. Hence, when the operator pulls the wire  43  from the outside of the body, the cap  41   a  slides on the surface of the tube  42 , the entire slider  41  moves downward as illustrated in  FIG. 9  and the engaging groove  26  of the lock bar  24  engages with the penetration hole  11 . 
     In addition, near the distal end of the tube  42  and on the insertion route  3  of the catheter  19 , the tube  42  has a holding part  46  in which a penetration hole  45  through which the catheter  19  penetrates is formed. Further, the other end of the wire  43  forms a ratchet mechanism  47  which is disposed outside the body or the surface of the body, and this ratchet mechanism  47  fixes the position of the wire  43  in one direction. Further, this ratchet mechanism  47  can cancel the engaged state of the catheter  19  and catheter fixture  40  by canceling the ratchet operation of the ratchet mechanism  47  and pushing the wire  43  toward the distal end side. In addition, similar to the slide bar  21  according to the first embodiment, the tube  42  has the function of the flange which abuts on the organ  1 . 
     Further, as illustrated in  FIG. 10 , a configuration is possible where, instead of the wire  43 , a slider  51  is movable bidirectionally by discharging and suctioning a fluid. That is, the distal end of a tube  52  corresponding to the tube  42  is inserted in a cap  51   a  of the slider  50 , and, at this distal end, a stretching part  53  is formed which is stretched in the cap  51   a  by a fluid discharged and suctioned in the internal passage. The other end of the tube  52  is provided with a fluid pump  57  which discharges and suctions a fluid, and the fluid pump  57  discharges and suctions the fluid in and from the tube  52  to stretch the stretching part  53 . The distal end of the stretching part  53  is latched with the cap  51   a  at a latch part  54  in the cap  51   a . Following stretching of this stretching part  53 , when the cap  51   a  moves in up and down directions as illustrated in  FIG. 10 , the entire slider  51  moves in the up and down directions and the engaging groove  26  of the lock bar  24  engages or disengages with the penetration hole  11 . Further, this engaged state is maintained by stopping the flow of the fluid by the fluid pump  57 . 
     The state where the engaging groove  26  of the lock bar  24  engages with the penetration hole  11  is a state where the catheter  19  is fixed to the organ  1 , and, in this state, a drug is administered to the tumor inside the organ  1  from a drug administration pump  58  connected to the proximal end side of the catheter  19  through the drug discharge holes  16 . In addition, similar to  FIG. 9 , near the distal end of the tube  52  and on the insertion route  3  of the catheter  19 , the tube  52  has a holding part  56  in which a penetration hole  55  through which the catheter  19  penetrates is formed. 
     With this third embodiment, the catheter fixture  40  or  50  and catheter  19  can be engaged and disengaged from the outside of the body by moving the slider  41  or  51 , that is, the catheter fixture  40  or  50  using the cap  41   a  or  51   a  and tube  42  or  52  and using the wire  43  or fluid in this tube  42  or  52 , so that it is possible to easily exchange the catheter  19  without opening the abdominal cavity again. 
     Fourth Embodiment 
     Next, a fourth embodiment of the present invention will be described. Although, with the above first to third embodiments, the catheter fixture and catheter are disposed by opening the abdominal cavity, with this fourth embodiment, the catheter  19  can be inserted and fixed by, for example, a manipulation using a laparoscope. 
     That is, as illustrated in ( 1 ) of  FIG. 11 , a catheter  69  has an engaging groove  66  which is a first engaging structure, in a proximal end part of a distal end part  62  corresponding to the distal end part  12  according to the first embodiment, drug discharge holes  16  formed in a punching area  63  and a flange  68  corresponding to the flange  18  according to the first embodiment. A catheter fixture  70  has at its distal end a gripping part  71  such as a pair of forceps which grips the engaging groove  66  and which is the second engaging structure. 
     Further, when the catheter  69  is fixed to the organ  1 , as illustrated in ( 2 ) of  FIG. 11 , the catheter  69  is first inserted in the organ  1  until the flange  68  abuts on the organ  1 , and exposes the engaging groove  66  on the discharge side. Then, as illustrated in ( 3 ) of  FIG. 11 , a catheter fixture  70  is moved to the vicinity of the engaging groove  66  by bending the gripping part  71 . Further, as illustrated in ( 4 ) of  FIG. 11 , the gripping part  71  grips the engaging groove  66  to engage and fix the catheter  69  and the catheter fixture  70  to the organ  1 . In addition, similar to, for example, a treatment tool used for an endoscope, the catheter fixture  70  has an opening/closing and rotating mechanism which opens/closes and rotates the gripping part  71  positioned at the distal end from the outside of the body, and a bending mechanism which bends the holding part near the gripping part  71  from the outside of the body. 
     In addition, as illustrated in  FIG. 12 , a protecting part  72  may be provided which extends from the proximal end part of the gripping part  71  and which corresponds to the protecting part  27  according to the first embodiment. Further, as illustrated in  FIG. 13 , a hook  81  may be used instead of the gripping part  71 . In this case, by engaging the hook  81  with the engaging groove  66  and closing an opening/closing part  82 , the engaged state is maintained. 
     Fifth Embodiment 
     Next, a fifth embodiment of the present invention will be described. Although the above first engaging structure is one penetration hole  11  or one engaging groove  66  provided in the catheter body  8 , with this fifth embodiment, as illustrated in ( 1 ) of  FIG. 14 , a plurality of engaging wire rods  101  and  102  are provided which extend from a distal end of a catheter  99  corresponding to the catheter  19  according to the first embodiment, and, as illustrated in ( 2 ) of  FIG. 14 , a plurality of engaging parts  121  and  122  are provided which engage with respective distal end parts of a plurality of engaging wire rods  101  and  102  and the catheter  99  is fixed to the organ  1  by engaging the engaging parts  121  and  122  with the engaging wire rods  101  and  102 , respectively. 
     As illustrated in ( 1 ) of  FIG. 14 , in addition to the internal passage  9  in which a drug flows, a catheter body  98  of this catheter  99  allows penetration of the engaging wire rods  101  and  102  respectively in internal passages  111  and  112  provided in the catheter  99  along this internal passage  9 . Penetration holes  101   a  and  102   a  are provided at each tip of each engaging wire rod  101  and  102 . 
     In a state where each engaging wire rod  101  and  102  is accommodated in each internal passage  111  and  112 , this catheter  99  is inserted until a flange  108  abuts on the organ  1  as illustrated in ( 2 ) of  FIG. 14 . Then, each engaging wire rod  101  and  102  accommodated in each internal passage  111  and  112  is projected and penetrates in the organ  1  to project outside the organ  1 . Meanwhile, an opening at the distal end of each internal passage  111  and  112  diagonally opens in a radial direction, and each engaging wire rod  101  and  102  widens and projects outside the organ  1 . Further, the opening at the distal end of each internal passage  111  and  112  is provided in a distal end part  92  corresponding to the distal end part  12  according to the first embodiment. Further, the drug discharge holes  16  are provided in a punching area  93  corresponding to the punching area  13  according to the first embodiment. 
     As illustrated in ( 2 ) of  FIG. 14 , each engaging part  121  and  122  which engages with each engaging wire rod  101  and  102  has flanges  121   a  and  122   a  which correspond to the slide bar  21  or flange  31  according to the first embodiment, lock parts  121   b  and  122   b  which correspond to the lock bar  24  according to the first embodiment, protecting parts  121   c  and  122   c  which correspond to the protecting part  27  according to the first embodiment and penetration holes  121   d  and  122   d  which correspond to the penetration hole  22  or penetration hole  32 . After each engaging wire rod  101  and  102  projects, the tip of each engaging wire rod  101  and  102  passes in each penetration hole  121   d  and  122   d , each lock part  121   b  and  122   b  passes in penetration holes  101   a  and  102   a  provided at the tip of each engaging wire rod  101  and  102  and each engaging wire rod  101  and  102  is extended from outside the body to fix the catheter  99  to the organ  1 . Meanwhile, the first engaging structure is the penetration holes  101   a  and  102   a , and the second engaging structure is the lock parts  121   b  and  122   b.    
     With this fifth embodiment, each engaging wire rod  101  and  102  in the engaged state is extended and the catheter  99  is reliably and flexibly fixed to the organ  1 . Further, the distal end side of the catheter  99  is fixed at a plurality of points in a dispersed manner, so that the catheter  99  can be more reliably fixed to the organ  1 . 
     Sixth Embodiment 
     Next, a sixth embodiment of the present invention will be described. With this sixth embodiment, the insertion direction of the catheter with respect to the organ  1  can be changed based on an arrangement relationship of surrounding organs. That is, with this sixth embodiment, as illustrated in  FIG. 15 , a bent part  210  is provided on a proximal end part side of the drug administration holes  16 . With a catheter  209  illustrated in  FIG. 15 , the bent part  210  adopting an accordion structure is provided on the proximal end side of a flange  208 , and, in  FIG. 15 , the invasion direction of the catheter  209  is left and right directions, and the insertion direction of the catheter  209  to the organ  1  is up and down directions. In addition, at the distal end of the catheter  209 , an engaging part  131  is provided which is the same as the engaging parts  121  and  122  illustrated in  FIG. 14 , such that the penetration hole  11  provided at the tip of the catheter  209  and a locking part  131   b  of the engaging part  131  engage. 
     In addition, as illustrated in  FIG. 16 , a bent part  220  of an L-shaped pipe may be provided instead of the bent part  210  adopting the accordion structure. Further, in  FIG. 16 , instead of the engaging part  131 , a gripping part  221  and protecting part  227  respectively corresponding to the gripping part  71  and protecting part  72  illustrated in  FIG. 12  grip and engage with the distal end of a catheter  219 . 
     Seventh Embodiment 
     Next, a seventh embodiment of the present invention will be described. Although, with the above first to sixth embodiments, all catheters adopt a structure of a closed distal end, with this seventh embodiment, a catheter having the open distal end is used. 
     That is, as illustrated in  FIG. 17 , a catheter  309  forms a thin pipe having an open distal end and the diameter of about 1 mm, and, as illustrated in ( 1 ) of  FIG. 17 , the drug administration holes  16  are inserted in the organ  1  until the drug administration holes  16  are positioned in the tumor  2  of the organ  1 . Then, as illustrated in ( 2 ) of  FIG. 17 , using a catheter fixture  310  having a gripping part  311  formed with a pair of forceps at the distal end, the gripping part  311  grips the distal end portion of the catheter  309  projecting from the organ  1  and further strongly sandwiches the distal end portion to crush and block the internal passage of the catheter  309 , and the gripping part  311  maintains this gripping state. In this state, a drug which flows in the internal passage of the catheter  309  can be discharged from the drug discharge holes  16 . 
     In addition, as illustrated in  FIG. 18 , an opening  409   a  formed by diagonally cutting the distal end and having a sharp shape may be used. In this case, even if the diameter of a catheter  409  is thick, it is possible to smoothly insert the catheter  409  in the organ  1 . 
     Further, similar to the protecting part  72  illustrated in  FIG. 12 , a protecting part which extends from the proximal end part of the gripping part  311  to the vicinity of the distal end of the catheter  309  or catheter  409  may be provided to prevent the distal end of the catheter  309  or catheter  409  from damaging other organs or tissues. 
     With this seventh embodiment, the catheter having an open distal end can be used as is, so that a configuration is simple and the catheter and catheter fixture can be engaged at the same time when a drug administering catheter is formed. 
     Eighth Embodiment 
     Next, an eighth embodiment of the present invention will be described. With this eighth embodiment, as illustrated in ( 1 ) of  FIG. 19 , a catheter  509  is provided at its distal end with an engaging groove  506  which is a first engaging structure instead of the penetration hole  11 , and a catheter fixture  510  has a gripping part  511  having convex parts  521  and  522  and flanges  531  and  532  which are the second engaging structure which engages with this engaging groove  506 . As illustrated in ( 1 ) of  FIG. 19 , the catheter  509  is first inserted in the organ  1  until a flange  508  abuts on the organ  1 , and the engaging groove  506  of the distal end part is projected to the outside of the organ  1 . 
     Further, in a state where the gripping part  511  provided at the distal end of the catheter fixture  510  is opened, the gripping part  511  is moved to the vicinity of the distal end of the catheter  509 , the convex parts  521  and  522  are engaged with the engaging groove  506  and flanges  531  and  532  abut on the organ  1  (see ( 2 ) of  FIG. 19 ). Further, as illustrated in ( 3 ) of  FIG. 19 , to maintain this engaged state, a cylindrical fixing part  540  inserted on the outer side from the proximal end side of a catheter fixture  510  is slid and fixed to the gripping part  511 . By this means, the engaged state of the catheter  509  and catheter fixture  510  are reliably maintained, and the catheter  509  is fixed to the organ  1 . 
     With this eighth embodiment, even when the diameter of the catheter  509  is small, it is possible to reliably fix the catheter  509  to the organ  1  without providing a penetration hole. 
     Ninth Embodiment 
     Next, a ninth embodiment of the present invention will be described. Although, with this ninth embodiment, as illustrated in  FIG. 20 , the same catheter  609  as in the eighth embodiment is used, the catheter  609  has a greater diameter than the eighth embodiment, so that it is possible to provide a penetration hole  611  in the distal end part of the catheter  609 . A catheter fixture  610  is a fixing bar which serves as the slide bar  21  and lock bar  24 , and has at the distal end part an engaging groove  606  which engages with a penetration hole  611  and an elastic ball  625  at the distal-most end part. 
     When the catheter  609  is inserted in the organ  1  until a flange  608  of the catheter  609  abuts on the organ  1 , the distal end part projects outside the organ  1  and penetration hole  611  projects. The elastic ball  625  is elastically deformed and inserted in this penetration hole  611 , and the engaging groove  606  engages with the penetration hole  611 . By this means, the catheter  609  and catheter fixture  610  engage, and the catheter  609  is fixed to the organ  1 . 
     In addition, similar to the protecting part  72  illustrated in  FIG. 12 , the catheter fixture  610  is provided with a protecting part which extends from the proximal end part of the engaging groove  606  to the vicinity of the distal end of the catheter  609  to prevent the distal end of the catheter  609  from damaging other organs and tissues. 
     With this ninth embodiment, it is possible to fix the catheter  609  to the organ  1  with a simple configuration. 
     In addition, although, with the above first to ninth embodiments, the tumor  2  inside the organ  1  is a drug administration target, the drug administration target is not limited to the tumor  2  and may be a site of lesion or blood vessel concentrating part such as the spleen. 
     Additional advantages and modifications will readily occur to those skilled in the art. Therefore, the invention in its broader aspects is not limited to the specific details and representative embodiments shown and described herein. Accordingly, various modifications may be made without departing from the spirit or scope of the general inventive concept as defined by the appended claims and their equivalents.