Patent Publication Number: US-5296477-A

Title: Aminoalkyl benzoxazine and benzthiazine compounds having a high 5-HT1A affinity

Description:
This application is a division of our prior-filed copending U.S. application Ser. No. 07/945,492, filed Sep. 16, 1992, now allowed, which in turn is a division of Ser. No. 07/765,959, filed Sep. 26, 1991, now U.S. Pat. No. 5,196,434. 
    
    
     The present invention relates to new heterocycle-substituted alkylamines, to a process for preparing these and to pharmaceutical compositions containing them. 
     A large number of heterocycle-substituted alkylamines containing a benzoxazolinone, benzothiazolinone or benzoxazinone unit have already been described. 
     The Applicant has now discovered new heterocycle-substituted alkylamines with a totally different chemical structure which possess the property of binding with a very high affinity to 5-HT 1A  serotoninergic receptors. This affinity is coupled with an excellent specificity and that renders them usable in the treatment of diseases of the serotoninergic system, and more especially depression, stress, anxiety and schizophrenia, at lower doses than the compounds of the prior art. This feature, combined with their low toxicity, renders the compounds of the invention usable with a great safety which is especially advantageous in view of the frailty of the populations at which this type of treatment is aimed. 
     More specifically, the present invention relates to the compounds of general formula (I): ##STR2## in which: R 1  represents a hydrogen atom or a lower alkyl group, 
     n represents 1 or 2, 
     A represents an oxygen or sulfur atom, 
     X represents a CH 2  group or a single bond, 
     R 2  represents a hydrogen atom or a lower alkyl or lower acyl group while R 3  represents a group (CH 2 ) p  R 4 , with p an integer between 1 and 6, and R 4  represents: 
     either a nitrile group, and in this case R 3  represents a group (CH 2 ) p-1  R 4  or a halogen atom or an amino group optionally substituted with: 
     a (lower alkyl)sulfonyl group, 
     a phenylsulfonyl group optionally substituted on the phenyl ring with one or more lower alkyl, lower alkoxy, hydroxyl or trifluoromethyl groups or a halogen atom, 
     one or two (C 1  -C 6 ) acyl groups optionally substituted with a lower alkyl, lower alkoxy or hydroxyl group, a halogen atom or a phenyl, thienyl, benzothienyl, indolyl, furyl or benzofuryl group, the phenyl, thienyl, benzothienyl, indolyl, furyl and benzofuryl groups themselves optionally being substituted with one or more lower alkyl, lower alkoxy or hydroxyl groups or a halogen atom, 
     one or two linear or branched (C 1  -C 6 ) alkyl groups, 
     or R 4  represents any one of the following groups: ##STR3##  in which: Y and Y&#39;, which may be identical or different, represent a hydrogen atom, a halogen atom or a lower alkyl, lower alkoxy or hydroxyl group, 
     m is an integer equal to 1 or 2, 
     their enantiomers, diastereoisomers and epimers as well as their addition salts with a pharmaceutically acceptable acid or a pharmaceutically acceptable base when R 1  =H. 
     Among pharmaceutically acceptable acids, hydrochloric, sulfuric, tartaric, maleic, fumaric, oxalic, methanesulfonic, camphoric, ethanesulfonic and citric acids, and the like, may be mentioned without implied limitation. Among pharmaceutically acceptable bases, sodium, potassium and calcium hydroxides, as well as sodium, potassium and calcium carbonates, and the like, may be mentioned without implied limitation. 
     The invention also encompasses the process for preparing the compounds of general formula (I), wherein a derivative of formula (II): ##STR4## with Hal representing a halogen atom and R 1 , A and X having the same definition as in the formula (I), and n&#39; represents 1 or 3, is used as a starting material, which compound is treated with a trialkylsilane in an acid medium to yield a compound of formula (III): ##STR5## with A, X, R 1 , n and Hal as defined above, which is condensed: 
     either with an amine of formula: ##STR6## with R 2  and R 3  having the same definition as above, to yield a compound of formula (I): ##STR7## with R 1 , X, A, n, R 2  and R 3  having the same definition as above, the isomers of which are separated, where appropriate, and purified if necessary by chromatography or crystallization, 
     or an amine of formula: 
     
         H.sub.2 NR.sub.3                                           (IV/a) 
    
     in which R 3  has the same definition as above, to yield a compound of formula (I/a): ##STR8## a special case of the compounds of formula (I), in which X, A, R 1 , n and R 3  have the same definition as in the formula (I) and R 2  in this case represents a hydrogen atom, which is purified, if so desired, by chromatography and/or crystallization, the isomers of which are separated, where appropriate, and which is treated, if so desired, with a compound of formula (IV/b) in an alkaline medium: 
     
         Hal.sub.a --R.sub.2                                        (IV/b) 
    
     in which Hal a  represents a halogen atom and R 2  has the same meaning as above, to yield a compound of formula (I), which is purified if necessary by chromatography and/or crystallization and the isomers of which are separated, where appropriate, which compound of formula (I) or (I/a), irrespective of the process according to which it has been obtained, may be, if so desired, salified with a pharmaceutically acceptable acid or base. 
     The compounds for which R 3  =H may be used as intermediates in the synthesis of the compounds of formula (I). In this case, the compound of formula (I/a1): ##STR9## where X, R 1  and A have the same definition as in the formula (I) and R&#39;2 represents a hydrogen atom or a lower alkyl group, or one of its addition salts with a pharmaceutically acceptable acid or, where appropriate, base, is treated 
     either with a compound of formula (V): 
     
         R.sub.4 --(CH.sub.2)p--Hal&#39;                                (V) 
    
     in which Hal&#39; represents a halogen atom and R 4  and p have the same definition as above, in the presence of an alkaline agent, to yield a compound of formula (I/b): ##STR10## a special case of the compounds of formula (I) for which R 1 , X, A, n, p, R&#39; 2  and R 4  have the same meaning as above, the isomers of which compound of formula (I/b) are separated, where appropriate, which is purified, if so desired, by a technique of chromatography or of crystallization and which is treated, when R&#39; 2  represents a hydrogen atom and R 2  a lower alkyl group, with a derivative of formula (VI): 
     
         R.sub.2 --Hal&#34;                                             (VI) 
    
     in which R 2  has the same meaning as in the formula (I) and Hal&#34; represents a halogen atom, to obtain a compound of formula (I), the isomers of which are separated and which is purified if necessary by a technique of chromatography or of crystallization, 
     either with a compound of formula (V) as defined above, to yield a compound of formula (I), which is purified if necessary by chromatography and/or crystallization after separation of the isomers, where appropriate, 
     or with a compound of formula (VII): 
     
         Par--(CH.sub.2)p-1Hal&#39;&#34;                                    (VII) 
    
     in which p has the same meaning as in the formula (I), Hal&#39;&#34; represents a halogen atom and Par represents either a CN group or a group CH 2  Hal 4 , where Hal4 represents a halogen atom, to yield a compound of formula (I/d): ##STR11## in which X, A, R 1 , n, p, Par and R&#39; 2  have the same definition as above, the isomers of which are separated, where appropriate, which is purified if necessary by chromatography and/or crystallization and which is treated, if so desired, either by catalytic hydrogenation or with an alkali metal mixed hydride in a C 1  -C 6  aliphatic alcohol medium when Par Par represents a CN group, or with an excess of ammonia when Par represents a group CH 2  Hal 4 , where Hal 4  has the same definition as above, to yield a compound of formula (I/e): ##STR12## in which R 1 , X, A, n, R&#39; 2  and p have the same definition as above, the isomers of which are separated, where appropriate, which is purified, if so desired, by chromatography and/or crystallization and which is reacted with a compound of formula (VIII): 
     
         R&#39;.sub.4 SO.sub.2 Hal&#34;&#34;                                    (VIII) 
    
     in which R&#39; 4  is a lower alkyl group or a phenyl group optionally substituted with one or more lower alkyl, lower alkoxy, hydroxyl or trifluoromethyl groups or a halogen atom and Hal&#34;&#34; is a halogen atom, to yield a compound of formula (I/f): ##STR13## in which R 1 , X, A, n, p, R&#39; 2  and R&#39; 4  have the same definition as above, the isomers of which are separated, where appropriate, and which is purified if necessary by a technique selected from crystallization and/or chromatography, which compounds of formula (I/b), (I/d), (I/e) or (I/f), irrespective of the process according to which they have been obtained, may be salified by adding a pharmaceutically acceptable base or acid. 
     The compounds of formula (I) possess advantageous pharmacological properties. 
     Binding tests showed that the compounds of the invention behave as very potent ligands of 5-HT 1A  receptors. This affinity is accompanied by a very great selectivity with respect to other receptors, in particular D 2  and α 2 , in contrast to the behavior observed with the compounds of the prior art. 
     The compounds of the invention are of low toxicity, and possess good activity in the pigeon conflict test, confirming the activity detected by binding. Some of them possess, moreover, an excellent analgesic activity, others a noteworthy hypnotic, antihypertensive or normolipemic activity. 
     The compounds of the invention hence find their application in the treatment of distress, anxiety, depression, schizophrenia, psychoses, dementia, senile dementia, aggressiveness and agitation, but also, for some of the compounds, in painful manifestations in all their forms, sleep disorders, arterial hypertension, glaucoma and the prevention of atheroma. 
     The subject of the present invention is also pharmaceutical compositions containing as active principle at least one compound of general formula (I) or one of its addition salts with a pharmaceutically acceptable acid or, where appropriate, with a pharmaceutically acceptable base, alone or in combination with one or more non-toxic, inert excipients or vehicles. 
     Among the pharmaceutical compositions according to the invention, there may be mentioned, more especially, those which are suitable for oral, parenteral or nasal administration, simple or sugar-coated tablets, sublingual tablets, sachets, packets, hard gelatin capsules, sublingual preparations, troches, suppositories, creams, ointments, skin gels, and the like. 
     The dosage varies according to the patient&#39;s age and weight and the nature and severity of the condition, as well as the administration route. The latter may be oral, nasal, rectal or parenteral. 
     Generally speaking, single doses range between 0.05 and 30 mg for conditions affecting mental behavior and between 1 mg and 500 mg for the treatment of pain and of arterial hypertension, that is to say, taken in one to three doses per 24 hours. 
    
    
     The examples which follow illustrate the invention and in no way limit the latter. 
     The 1H nuclear magnetic resonance spectra were recorded using TMS (tetramethylsilane) as an internal reference. The chemical shifts are expressed in parts per million (ppm). The infrared spectra were run in the form of a potassium bromide disk containing approximately 1% of the product to be analyzed. 
     The preparations do not form part of the invention, but are useful for carrying out the synthesis of the compounds of the invention. 
     PREPARATION 1 
     6-(Bromoacetyl)benzothiazolinone 
     210 g (1.60 mol) of aluminum chloride are introduced into a 500-cm 3  ground-necked flask surmounted by a condenser, and 43 cm 3  of dimethylformamide are then added dropwise and with magnetic stirring via a dropping funnel. 30.2 g (0.2 mol) of benzothiazolinone are then added and, while the reaction medium homogenizes, the temperature is stabilized at 70° C. using an oil bath. 19.8 cm 3  (0.24 mol) of bromoacetyl chloride are then introduced gradually. After the addition, the mixture is left stirring for one hour at a temperature of 70° C. The reaction medium is hydrolyzed by pouring it onto crushed ice and the precipitate obtained is drained, washed copiously with water and dried. The product is recrystallized in dioxane. 
     Yield: 65% 
     Melting point: 235° C. with decomposition 
     PREPARATION 2 
     6-(2-Bromoethyl)benzothiazolinone 
     In a 500-cm 3  ground-necked flask surmounted by a condenser, and placed in an oil bath, 40.8 g (0.15 mol) of 6-(bromoacetyl)benzothiazolinone are dissolved in 90 cm 3  of trifluoroacetic acid with magnetic stirring and while the temperature is stabilized at 60° C. 52.7 cm 3  (0.33 mol) of triethylsilane are introduced dropwise via a dropping funnel. After the addition, the heating is stopped and the mixture is then left stirring vigorously for 30 hours. The reaction medium is hydrolyzed by pouring it into ice-cold water, and the precipitate obtained is drained and washed with water until the filtrate is neutral and then with hexane. The product is dried and recrystallized in absolute ethanol. 
     Yield: 80% 
     Melting point: 179°-180° C. 
     PREPARATION 3 
     3-Methylbenzothiazolinone 
     In a 2-liter flask, 75.6 g (0.5 mol) of benzothiazolinone are dissolved in a solution containing 20 g of sodium hydroxide (0.5 mol) in approximately 800 cm 3  of water. The solution is filtered. With magnetic stirring, 47.5 cm 3  of methylsulfate (0.5 mol) are introduced dropwise with a dropping funnel. After the addition, the mixture is left stirring for 20 hours at room temperature. The medium is alkalinized with a slight excess of sodium hydroxide and left stirring for one hour. The precipitate obtained is drained and washed with water until the filtrate is neutral. The product is dried. It is recrystallized in propanol. 
     Yield: 88% 
     Melting point: 72°-74° C. 
     PREPARATION 4 
     3-Methyl-6-(bromoacetyl)benzothiazolinone 
     210 g (1.60 mol) of aluminum chloride are introduced into a 500-cm 3  ground-necked flask surmounted by a condenser, and 43 cm 3  of dimethylformamide are then added dropwise and with magnetic stirring via a dropping funnel. 33 g (0.20 mol) of 3-methylbenzothiazolinone are then added and, while the reaction medium homogenizes, the temperature is stabilized at 70° C. using an oil bath. 19.8 cm 3  (0.24 mol) of bromoacetyl chloride are then added gradually. After the addition, the mixture is left stirring for one hour at a temperature of 70° C. The reaction medium is hydrolyzed by pouring it onto crushed ice and the precipitate obtained is drained, washed with water until the filtrate is neutral and dried. The product is recrystallized in 95° strength alcohol. 
     Yield: 66% 
     Melting point: 164°-165° C. 
     PREPARATION 5 
     3-Methyl-6-(2-bromoethyl)benzothiazolinone 
     In a 500-cm 3  ground-necked flask surmounted by a condenser and placed in an oil bath, 42.9 g (0.15 mol) of 3-methyl-6-(bromoacetyl)benzothiazolinone are dissolved in 77 cm 3  of trifluoroacetic acid with magnetic stirring and while the temperature is stabilized at 60° C. 52.7 cm 3  (0.33 mol) of triethylsilane are introduced dropwise via a dropping funnel. After the addition, the heating is stopped and the mixture is left stirring vigorously for 30 hours. The reaction medium is hydrolyzed by pouring it into ice-cold water, and the precipitate obtained is drained and washed with water until the filtrate is neutral and then with hexane. The product is dried and recrystallized in cyclohexane. 
     Yield: 86% 
     Melting point: 97°-98° C. 
     PREPARATION 6 
     7-(Bromoacetyl)benzoxazinone 
     0.01 mol of 7-acetylbenzoxazinone, described in Application EP 223,674, is dissolved in 100 cm 3  of methylene chloride. 0.011 mol of bromine is added dropwise and with stirring via a dropping funnel, and stirring is maintained for 13 hours. The mixture is filtered and evaporated to dryness and the residue is recrystallized. 
     PREPARATION 7 
     6-(2-Bromoethyl)-3-oxo-2,3-dihydro-1,4-benzoxazine 
     This product is advantageously obtained either by catalytic hydrogenation of 6-(bromoacetyl)-3-oxo-2,3-dihydro-1,4-benzoxazine, described in French Patent Application 2,035,749, in an acetic acid medium in the presence of palladinized charcoal, or by the action of trialkylsilane on this compound in a trifluoroacetic acid medium. 
     PREPARATION 8 
     4-Methyl-7-(2-bromoethyl)-3-oxo-2,3-dihydro-1,4-benzoxazine 
     0.01 mol of 4-methyl-7-acetyl-3-oxo-2,3-dihydro-1,4-benzoxazine, obtained in European Patent Application 0,223,674, is dissolved in methylene chloride. 0.012 mol of bromine is added with stirring via a dropping funnel. 
     Stirring is maintained for two hours, and the reaction medium is then left in a oil bath at 40° C. with stirring for 2 hours. The mixture is filtered. The solvent is evaporated off. The residue is recrystallized. 
     The 4-methyl-7-(bromoacetyl)-3-oxo-2,3-dihydrobenzoxazine is converted to 4-methyl-7-(2-bromoethyl)-3-oxo-2,3-dihydro-1,4-benzoxazine by catalytic hydrogenation in an acetic acid medium in the presence of palladinized charcoal, or by the action of trialkylsilane in a trifluoroacetic acid medium. 
     PREPARATION 9 
     6-(2-Propylaminoethyl)-3-oxo-2,3-dihydro-1,4-benzoxazine 
     In a round-bottomed flask equipped with a mechanical stirrer and a calcium chloride guard tube, 0.01 mol of n-propylamine and 0.015 mol of triethylamine are added to a solution of 6-(2-bromoethyl)-3-oxo-2,3-dihydro-1,4-benzoxazine in 40 cm 3  of dimethylformamide. The mixture is heated to reflux for 15 hours and the precipitate formed is drained in the heated state. The residue is evaporated under vacuum and the product is recrystallized. 
     PREPARATION 10 
     6-(4-Bromobutyl)benzothiazolinone 
     Using the procedure described in Preparation 2, but replacing 6-(bromoacetyl)benzothiazolinone by 6-(4-bromobutyryl)benzothiazolinone, the product of the title is obtained. 
     PREPARATION 11 
     3-Methyl-6-(4-bromobutyl)benzothiazolinone 
     Using the procedure described in Preparation 5, but replacing 6-(bromoacetyl)-3-methylbenzothiazolinone by 3-methyl-6-(4-bromobutyryl)benzothiazolinone, the product of the title is obtained. 
     PREPARATION 12 
     7-(4-Bromobutyl)-4-methyl-2,3-dihydro-3-oxobenzoxazine 
     Using the procedure described in Preparation 2, but replacing 6-(bromoacetyl)benzothiazolinone by 7-(4-bromobutyryl)-4-methyl-2,3-dihydro-3-oxobenzoxazine, described in Application EP 0,223,674, the product of the title is obtained. 
     PREPARATION 13 
     6-(4-Bromobutyl)benzoxazolinone 
     Using the procedure described in Preparation 2, but replacing 6-(bromoacetyl)benzothiazolinone by 6-(4-bromobutyryl)benzoxazolinone, described in Patent Application EP 0,281,309, the product of the title is obtained. 
     PREPARATION 14 
     3-Methyl-6-(4-bromobutyl)benzoxazolinone 
     Using the procedure described in Preparation 13, but replacing 6-(4-bromobutyryl)benzoxazolinone by 3-methyl-6-(4-bromobutyryl)benzoxazolinone, the product of the title is obtained. 
     EXAMPLE 1 
     3-Methyl-6-(2-aminoethyl)benzothiazolinone (hydrochloride) 
     In a 250 cm 3  ground-necked flask, 8.1 g (0.03 mol) of 3-methyl-6-(2-bromoethyl)benzothiazolinone and 0.9 g of potassium iodide are dissolved in 120 cm 3  of methanol and 30 cm 3  of chloroform. A stream of gaseous ammonia is bubbled into the solution to the point of saturation, equivalent to approximately 2.6 g of ammonia, and a reflux condenser is then fitted. The temperature is stabilized at 50° C. with an oil bath and the mixture is left stirring magnetically for 72 hours. After cooling, the reaction mixture is evaporated on a water bath under vacuum. The residue is ground with distilled water acidified with 5% HCl solution, and then drained. The filtrate is recovered, washed with ethyl acetate and then alkalinized with 10% sodium hydroxide solution. It is extracted with chloroform, leaving the 2 phases agitating for 1/2 hour, and the organic phase is washed with distilled water and then dried over calcium chloride. The organic phase is evaporated on a water bath under vacuum, the residue is then taken up in absolute ethanol, a stream of gaseous HCl is bubbled through and the mixture is then evaporated to dryness on a water bath under vacuum. The product is dried and then recrystallized in absolute ethanol. 
     Yield: 32% 
     Melting point: 228°-230° C. 
     Molecular weight: 244.75 g/mol 
     Percentage composition: Calculated: C 49.07; H 5.35; N 11.45. Found: C 49.17; H 5.38; N 11.48. 
     Infrared spectrometry: 3100-2800 cm -1  : ν(C--H). 2750-2400 cm -1  : ν(NH+). 1680 cm -1  : ν(C═O) --O--CO--NR--. 1600-1580 cm -1  : ν(C═C) aromatic. 
     Nuclear magnetic resonance spectrometry: Solvent: DMSO-d 6 . δ=3.00 ppm unresolved peaks; (4H). δ=3.38 ppm singlet; (3H) NCH 3 . δ=7.28 ppm unresolved peaks; (2H) H4,5 aromatic. δ=7.55 ppm unresolved peaks; (1H) H7 aromatic. δ=8.17 ppm signal; (3H) (NH3+). 
     The base is obtained by dissolution of the hydrochloride in water, alkalinization and three extractions with chloroform. The chloroform phases are combined, dried over calcium chloride and evaporated to dryness. The residue may be used without further purification as a starting material. 
     EXAMPLE 2 
     3-Methyl-6-{2-[N-(4-phthalimidobutyl)amino]ethyl}benzothiazolinone 
     In a round-bottomed flask, 2.2 mmol of 3-methyl-6-(2-aminoethyl)benzothiazolinone, obtained in the previous example, are dissolved in 20 ml of dimethyl-formamide in the presence of 2.4 mmol of N-(4-bromo-butyl)phthalimide, 6.6 mmol of potassium carbonate and a catalytic amount of potassium iodide. The mixture is left stirring at 60° C. for 6 hours. After cooling, the solvent is evaporated off and/or extracted with chloroform after adding water. 
     After washing, drying and evaporation of the organic phase, the expected product is obtained after purification by chromatography on a silica column, followed by crystallization. 
       1  H Nuclear Magnetic Resonance: Solvent: DMSO-d 6 . δ=1.75 ppm N--(CH 2 ) 2  --CH 2  --CH 2  -phthalimido 2H, multiplet. δ=3.38 ppm 3H, CH 3  singlet; (3H) NCH 3 . δ=3.62 ppm N--(CH 2 ) 3  --CH 2  -phthalimido 2H, triplet. 
     Infrared: 3100-2800 cm -1  : νCH. 1680 cm -1  : νCO (SCON). 
     EXAMPLE 3 
     3-Methyl-6-{2-[N-(4-phthalimidobutyl)-N-n-propylamino]ethyl}benzothiazolinone 
     1.5 mmol of 3-methyl-6-{2-[N-(4-phthalimidobutyl)amino]ethyl}benzothiazolinone, obtained in Example 2, is dissolved in 15 ml of dimethylformamide in the presence of 4.4 mmol of 1-iodopropane and 4.4 mmol of potassium carbonate. After 24 hours&#39; stirring at 60° C., the solvent is evaporated off and the reaction medium is taken up with 10 ml of water and extracted with chloroform. The organic phase is dried and evaporated and the expected product is obtained after purification by chromatography on a silica column, followed by crystallization. 
       1  H Nuclear Magnetic Resonance: Solvent: DMSO-d 6 . δ=0.88 ppm N--(CH 2 ) 2  --CH 3  ; triplet (3H). δ=1.75 ppm N--(CH 2 ) 2  --CH 2  --CH 2  -phthalimido; (2H), multiplet. δ=3.38 ppm (3H), N--CH 3 , singlet. δ=3.62 ppm N--(CH 2 ) 3  --CH 2  -phthalimido (2H), triplet. 
     Infrared: 3100-2800 cm -1  : νCH. 1680 cm -1  : νCO (SCON). 
     EXAMPLE 4 
     3-Methyl-6-{2-[N-(3-phthalimidopropyl)amino]ethyl}benzothiazolinone 
     Using the procedure described in Example 2, but replacing N-(4-bromobutyl)phthalimide by N-(3-bromopropyl)phthalimide, the product of the title is obtained. 
       1  H Nuclear Magnetic Resonance: Solvent: DMSO-d 6 . δ=3.38 ppm, 3H, CH 3 , singlet, N--CH 3 . δ=3.78 ppm, 2H, N(CH 2 ) 2  --CH 2  -phthalimido. 
     Infrared: 3100-2800 cm -1  : νCH. 1680 cm -1  : νCO (SCON). 
     EXAMPLE 5 
     3-Methyl-6-{2-[N-(3-phthalimidopropyl)-N-n-propylamino]ethyl}benzothiazolinone 
     Using the procedure described in Example 3, but replacing 3-methyl-6-{2-[N-(4-phthalimidobutyl)amino]-ethyl}benzothiazolinone by 3-methyl-6-{2-[N-(3-phthalimidopropyl)amino]ethyl}benzothiazolinone, obtained in Example 4, the expected product is obtained. 
       1  H Nuclear Magnetic Resonance: Solvent: DMSO-d6. δ=0.89 ppm, 3H, N--CH 2  --CH 2  --CH 3 , triplet. δ=3.38 ppm, 3H, N--CH 3 , singlet. 
     Infrared: 3100-2800 cm -1  : νCH. 1680 cm -1  : νCO (SCON). 
     EXAMPLE 6 
     3-Methyl-6-{2-[N-(2-phthalimidoethyl)amino]ethyl}benzothiazolinone 
     Using the procedure described in Example 2, but replacing N-(4-bromobutyl)phthalimide by N-(2-bromoethyl)phthalimide and leaving the reactants stirring for 40 hours, the expected product is obtained.  1  H Nuclear Magnetic Resonance: Solvent: DMSO-d 6 . δ=3.39 ppm, 3H, CH 3 , singlet, N-CH 3 . δ=3.80 ppm, 2H, N(CH 2 ) 2  --CH 2  -phthalimido. 
     Infrared: 3100-2800 cm -1  : νCH. 1680 cm -1  : νCO (SCON). 
     EXAMPLE 7 
     3-Methyl-6-{2-[N-(2-phthalimidoethyl)-N-n-propylamino]-ethyl}benzothiazolinone 
     Using the procedure described in Example 3, but replacing 3-methyl-6-{2-[N-(4-phthalimidobutyl)amino]-ethyl}benzothiazolinone by 3-methyl-6-{2-[N-(2-phthalimidoethyl)amino]ethyl}benzothiazolinone, the product of the title is obtained. 
       1  H Nuclear Magnetic Resonance: Solvent: DMSO-d 6 . δ=3.39 ppm, 3H, CH 3 , singlet, N--CH 3 . 
     Infrared: 3100-2800 cm -1  : νCH. 1680 cm -1  : νCO (SCON). 
     EXAMPLE 8 
     3-[4-{N-[2-(3-methylbenzothiazolinon-6-yl)ethyl]amino}butyl]-2,4-dioxo-3-azaspiro[4.5]decane 
     Using the procedure described in Example 2, but replacing N-(4-bromobutyl)phthalimide by N-(4-bromo-butyl)-2,4-dioxo-3-azaspiro[4.5]decane and leaving the reactants stirring for 24 hours, the product of the title is obtained. 
       1  H Nuclear Magnetic Resonance: Solvent: DMSO-d 6 . δ=2.59 ppm, 4H, singlet, N(CO--CH 2 ) 2 . δ=3.50 ppm, 3H, singlet, N--CH 3 . 
     Infrared: 3000-2800 cm -1  : νCH. 1600-1680 cm -1  : νCO (overlapping). 
     EXAMPLE 9 
     3-[4-{N-[2-(3-methylbenzothiazolinon-6-yl)ethyl]-N-propylamino}butyl]-2,4-dioxo-3-azaspiro[4.5]decane 
     Using the procedure described in Example 3, but replacing the compound obtained in Example 2 by the compound obtained in Example 8, the product of the title is obtained. 
     EXAMPLE 10 
     3-[4-{N-[2-(3-methylbenzothiazolinon-6-yl)ethyl]amino}butyl]-2,4-dioxo-3-azabicyclo[3.3.0]octane 
     Using the procedure described in Example 2, but replacing N-(4-bromobutyl)phthalimide by N-(4-bromobutyl)-2,4-dioxo-3-azabicyclo[3.3.0]octane and leaving the reactants stirring for 24 hours, the product of the title is obtained. 
     1H Nuclear Magnetic Resonance: Solvent: DMSO-d 6 . δ=3.39 ppm, 3H, N--CH 3 . δ=3.49 ppm, 2H, triplet, CH 2  --N (azabicyclooctane). 
     Infrared: 3100-2800 cm -1  : νCH. 1680 cm -1  : νCO (SCON). 
     EXAMPLE 11 
     3-Methyl-6-[2-{N-[4-(4,4-dimethyl-2,6-dioxo-1-piperidyl)butyl]amino}ethyl]benzothiazolinone 
     Using the procedure described in Example 2, but replacing N-(4-bromobutyl)phthalimide by N-(4-bromobutyl)-4,4-dimethyl-2,6-dioxopiperidine and leaving the reactants stirring for 24 hours, the expected product is obtained. 
       1  H Nuclear Magnetic Resonance: Solvent: DMSO-d 6 . δ=1.06 ppm, 6H, singlet C(CH 3 ) 2 . δ=3.39 ppm, N--CH 3 , 3H, singlet. 
     Infrared: 1680 cm -1  : νCO (SCON). 
     EXAMPLE 12 
     3-Methyl-6-[2-{N-[4-(4,4-dimethyl-2-oxo-1-piperidyl)butyl]amino}ethyl]benzothiazolinone 
     Using the procedure described in Example 2, but replacing N-(4-bromobutyl)phthalimide by 1-(4-bromo-butyl)-4,4-dimethyl-2-oxopiperidine and leaving the reactants stirring for 24 hours, the expected product is obtained. 
     EXAMPLE 13 
     3-Methyl-6-[2-{N-[4-(2-oxo-1-piperidyl)butyl]amino}-ethyl]benzothiazolinone 
     Using the procedure described in Example 2, but replacing N-(4-bromobutylphthalimide) by 1-(4-bromo-butyl)-2-oxopiperidine and leaving the reactants stirring for 24 hours, the expected product is obtained. 
     EXAMPLE 14 
     3-Methyl-6-[2-(N-methyl-N-benzylamino)ethyl]benzothiazolinone 
     0.04 mol of N-methyl-N-benzylamine and 0.02 mol of 3-methyl-6-(2-bromoethyl)benzothiazolinone, the latter being dissolved beforehand in 120 cm 3  of dioxane, are introduced into a 100-cm 3  ground-necked flask fitted with a reflux condenser. The mixture is heated to reflux for 96 hours with magnetic stirring. After cooling, the reaction mixture is filtered and the filtrate is then evaporated on a water bath under vacuum. The residue is taken up with 50 cm 3  and alkalinized with 10 cm 3  of normal sodium hydroxide solution. 
     The mixture is extracted three times with 60 cm 3  of chloroform. The organic solutions are combined, dried over calcium chloride, filtered and evaporated on a water bath under vacuum. The residue is taken up with petroleum ether, drained, dried and recrystallized. 
       1  H Nuclear Magnetic Resonance: Solvent: DMSO-d 6 . δ=2.22 ppm, N--CH 3  (CH 2  --N--CH 3 ), singlet 3H. δ=3.37 ppm, N--CH 3  (benzothiazolinone), singlet 3H. δ=3.53 ppm, N--CH 2  --C 6  H 5 , 2H, singlet. 
     EXAMPLE 15 
     3-Methyl-6-[2-(N-methylamino)ethyl]benzothiazolinone (hydrochloride) 
     Using the procedure described in Example 1, but replacing ammonia by N-methylamine, the product of the title is obtained. 
       1  H Nuclear Magnetic Resonance: Solvent: D 2  O (hydrochloride). δ=2.84 ppm, singlet 3H, N--CH 3 . δ=3.29 ppm, singlet 3H, N--CH 3 . 
     Infrared: 3100-2600 cm -1  : νNH and νCH. 1680 cm -1  : νCO (SCON). 
     EXAMPLE 16 
     3-Methyl-6-(2-propylaminoethyl)benzothiazolinone hydrochloride 
     Using the procedure described in Example 16, but replacing isopropylamine by n-propylamine, the product of the title is obtained. 
     Spectral characteristics: 
     Infrared: 3100-2650 cm -1  : νNH and νCH. 1680 cm -1  : νCO (SCON). 
     EXAMPLE 17 
     3-Methyl-6-[2-(N-methyl-N-cyanomethylamino)ethyl]benzothiazolinone 
     In a round-bottomed flask, 6.8 mmol of 3-methyl-6-[2-(N-methylamino)ethyl]benzothiazolinone -(N-methylamino)ethyl]benzothiazolinone are dissolved in 50 ml of dioxane in the presence of 20 mmol of chloro-acetonitrile, 20 mmol of potassium carbonate and a catalytic amount of potassium iodide. The mixture is stirred at 60° C. for 48 hours. After cooling, the solvent is evaporated off and the reaction mixture is extracted with chloroform after adding water. After washing, drying and evaporation of the organic phase, the expected product is obtained after purification by chromatography on a silica column, followed by crystallization. 
       1  H Nuclear Magnetic Resonance, DMSO-d 6 . δ=3.39 ppm, singlet, 3H, N--CH 3 . 
     Infrared: 1680 cm -1  : νCO (SCON). 
     EXAMPLE 18 
     3-Methyl-6-{2-[N-methyl-N-(2-aminoethyl)amino]ethyl}benzothiazolinone 
     In a ground-necked flask, 6 mmol of 3-methyl-6-[2-(N-methylamino)ethyl]benzothiazolinone are dissolved in 50 ml of dioxane, 20 mmol of 1-chloro-2-bromoethane and 20 mmol of potassium carbonate. The mixture is stirred for 48 hours at a temperature of 60° C. After cooling, the mixture is evaporated and the reaction medium is extracted with chloroform after adding water. After washing, drying and evaporation of the organic phase, 3-methyl-6-{2-[N-methyl-N-(2-chloroethyl)amino]ethyl}benzothiazolinone is obtained, which product is transferred to a ground-necked flask. A catalytic amount of potassium iodide, 25 cm 3  of methanol and 10 cm 3  of chloroform are added. A stream of gaseous ammonia is bubbled into the solution to the point of saturation and a reflux condenser is then fitted. The temperature is stabilized at 50° C. with an oil bath and the mixture is then left stirring magnetically for 72 hours. After cooling, the reaction mixture is evaporated on a water bath under vacuum. The residue is ground with distilled water acidified with 5% HCl solution, and then drained. The filtrate is recovered, washed with ethyl acetate and then alkalinized with 10% sodium hydroxide solution. It is extracted with chloroform, leaving the 2 phases agitating for 1/2 hour, and the organic phase is washed with distilled water and then dried over calcium chloride. The organic phase is evaporated on a water bath under vacuum, the residue is then taken up in absolute ethanol, a stream of gaseous HCl is bubbled through and the mixture is then evaporated to dryness on a water bath under vacuum. The product is dried and then recrystallized. 
       1  H Nuclear Magnetic Resonance: δ=3.38 ppm, singlet, 3H, N--CH 3 . 
     Infrared: 1680 cm -1  : νCO (SCON). 
     EXAMPLE 19 
     3-Methyl-6-[2-{N-methyl-N-[2-(para-tolylsulfonylamino)ethyl]amino}ethyl]benzothiazolinone 
     4 mmol of 3-methyl-6-{2-[N-methyl-N-(2-aminoethyl)amino]ethyl}benzothiazolinone, obtained in Example 19, are dissolved in 50 ml of dichloromethane cooled in ice, and 11.4 mmol of triethylamine are added dropwise, followed by 4 mmol of tosyl chloride dissolved in dichloromethane. 
     The mixture is left stirring for 30 minutes at room temperature. The solvent is then evaporated off and the expected product is obtained after purification by chromatography on a silica column. 
     Nuclear Magnetic Resonance: 1H (CDCl 3 ). δ=3.39 ppm, singlet, 3H, N--CH 3 . 
     Infrared: 1680 cm -1  : νCO (SCON). 
     EXAMPLE 20 
     3-Methyl-6-[2-(N-propyl-N-cyanomethylamino)ethyl]benzothiazolinone 
     Using the procedure described in Example 18, but replacing 3-methyl-6-[2-(N-methylamino)ethyl]benzothiazolinone by 3-methyl-6-[2-(N-propylamino)ethyl]-benzothiazolinone, the product of the title is obtained. 
     Nuclear Magnetic Resonance: 1H (CDCl 3 ). δ=3.39 ppm, singlet, 3H, N--CH 3 . 
     Infrared: 1680 cm -1  : νCO (SCON). 
     EXAMPLE 21 
     3-Methyl-6-{2-[N-propyl-N-(2-aminoethyl)amino]ethyl}benzothiazolinone 
     Using the procedure described in Example 19, but replacing 3-methyl-6-[2-(N-methyl-N-cyanomethylamino)-ethyl]benzothiazolinone by 3-methyl-6-[2-(N-propyl-N-cyanomethylamino)ethyl]benzothiazolinone, the product of the title is obtained. 
     EXAMPLE 22 
     3-Methyl-6-[2-{N-propyl-N-[2-(para-tolylsulfonylamino)ethyl]amino}ethyl]benzothiazolinone 
     Using the procedure described in Example 20, but replacing 3-methyl-6-{2-[N-methyl-N-(2-aminoethyl)amino]ethyl}benzothiazolinone by 3-methyl-6-{2-[N-propyl-N-(2-aminoethyl)amino]ethyl}benzothiazolinone, the product of the title is obtained. 
     EXAMPLE 23 
     3-Methyl-6-[2-{N-propyl-N-[3-para-tolylsulfonylamino)-propyl]amino}ethyl]benzothiazolinone 
     Using the procedure described in Example 19, but replacing 1-chloro-2-bromoethane by 1-chloro-3-bromopropane and 3-methyl-6-[2-(N-methylamino)ethyl]benzothiazolinone by 3-methyl-6-[2-(N-n-propylamino)ethyl]-benzothiazolinone, 3-methyl-6-{2-[N-methyl-N-(3-aminopropyl)amino]ethyl}benzothiazolinone is obtained, which product is treated as in Example 20 with tosyl chloride to yield the product of the title. 
     Nuclear Magnetic Resonance: 1H (CDCl 3 ). δ=3.38 ppm, singlet, 3H, N--CH 3   
     Infrared: 1760 cm -1  : νCO (SCON). 
     EXAMPLE 24 
     3-Methyl-6-[2-{N-propyl-N-[4-(para-tolylsulfonylamino)-butyl]amino}ethyl]benzothiazolinone 
     Using the procedure described in Example 24, but replacing 1-chloro-3-bromopropane by 1-chlorobromobutane, the product of the title is obtained. 
     EXAMPLE 25 
     3-Methyl-6-(4-aminobutyl)benzothiazolinone (hydrochoride) 
     Using the procedure described in Example 1, but replacing 3-methyl-6-(2-bromoethyl)benzothiazolinone by 3-methyl-6-(4-chlorobutyl)benzothiazolinone, 3-methyl-6-(4-aminobutyl)benzothiazolinone (hydrochloride) is obtained. 
     EXAMPLES 26 TO 37 
     Using the procedure described in Examples 2 to 13, but replacing 3-methyl-6-(2-aminoethyl)benzothiazolinone by 3-methyl-6-(4-aminobutyl)benzothiazolinone of Example 33, the following are obtained: 
     EXAMPLE 26 
     3-Methyl-6-{4-[N-(4-phthalimidobutyl)amino]butyl}benzothiazolinone 
     EXAMPLE 27 
     3-Methyl-6-{4-[N-(4-phthalimidobutyl)-N-n-propylamino]butyl}benzothiazolinone 
     EXAMPLE 28 
     3-Methyl-6-{4-[N-(3-phthalimidopropyl)amino]butyl}benzothiazolinone 
     EXAMPLE 29 
     3-Methyl-6-{4-[N-(3-phthalimidopropyl)-N-propylamino]butyl}benzothiazolinone 
     EXAMPLE 30 
     3-Methyl-6-{4-[N-(2-phthalimidoethyl)-N-n-propylamino]butyl }benzothiazolinone 
     EXAMPLE 31 
     3-Methyl-6-{4-[N-(2-phthalimidoethyl)amino]butyl}benzothiazolinone 
     EXAMPLE 32 
     3-[4-{N-[4-(3-methylbenzothiazolinon-6-yl)butyl]amino}-butyl]-2,4-dioxo-3-azaspiro[4.5]decane 
     EXAMPLE 33 
     3-[4-{N-[4-(3-methylbenzothiazolinon-6-yl)butyl]-N-n-propylamino}butyl]-2,4-dioxo-3-azaspiro[4.5]decane 
     EXAMPLE 34 
     3-[4-{N-[4-(3-methylbenzothiazolinon-6-yl)butyl]amino}-butyl]-2,4-dioxo-3-azabicyclo[3.3.0.]octane 
     EXAMPLE 35 
     3-Methyl-6-[4-{N-[4-(4,4-dimethyl-2,6-dioxo-1-piperidyl)-butyl]amino}butyl]benzothiazolinone 
     EXAMPLE 36 
     3-Methyl-6-[4-{N-[4-(4,4-dimethyl-2-oxo-1-piperidyl)-butyl]amino}butyl]benzothiazolinone 
     EXAMPLE 37 
     3-Methyl-6-[4-{N-[4-(2-oxo-1-piperidyl)butyl]amino}butyl]benzothiazolinone 
     EXAMPLE 38 
     3-Methyl-6-[4-(N-methyl-N-benzylamino)butyl]benzothiazolinone 
     Using the procedure described in Example 14, but replacing 3-methyl-6-(2-bromoethyl)benzothiazolinone by 3-methyl-6-(4-bromobutyl)benzothiazolinone, the product of the title is obtained. 
     EXAMPLE 39 
     3-Methyl-6-[4-(N-methylamino)butyl]benzothiazolinone 
     Using the procedure described in Example 15, but replacing 3-methyl-6-[2-(N-methyl-N-benzylamino)ethyl]benzothiazolinone by 3-methyl-6-[4-(N-methyl-N-benzylamino)butyl]benzothiazolinone, obtained in the previous example, the product of the title is obtained. 
     EXAMPLES 40 TO 42 
     Using the procedure described in Examples 18 to 20, but replacing 3-methyl-6-[2-(N-methylamino)ethyl]benzothiazolinone by 3-methyl-6-[4-(N-methylamino)butyl]benzothiazolinone, the following are obtained: 
     EXAMPLE 40 
     3-Methyl-6-[4-(N-methyl-N-cyanomethylamino)butyl]benzothiazolinone 
     EXAMPLE 41 
     3-Methyl-6-{4-[N-methyl-N-(2-aminoethyl)amino]butyl}benzothiazolinone 
     EXAMPLE 42 
     3-Methyl-6-[4-{N-methyl-N-[2-(para-tolylsulfonylamino)ethyl]amino}butyl]benzothiazolinone 
     EXAMPLE 43 
     7-{2-[N-(4-phthalimidobutyl)amino]ethyl}benzothiazolinone 
     Using the procedure described in Example 2, but replacing 3-methyl-6-(2-aminoethyl)benzothiazolinone by 7-(2-aminoethyl)benzothiazolinone, described in Example 8 of European Patent Application 174,811, the product of the title is obtained. 
     Using the same procedure as in Examples 3 to 13, but employing 7-(2-aminoethyl)benzothiazolinone as a starting material, the following are obtained: 
     EXAMPLE 44 
     7-{2-[N-(4-phthalimidobutyl)-N-n-propylamino]ethyl}benzothiazolinone 
     EXAMPLE 45 
     7-{2-[N-(3-phthalimidopropyl)amino]ethyl}-benzothiazolinone 
     EXAMPLE 46 
     7-{2-[N-(3-phthalimidopropyl)-N-n-propylamino]ethyl}benzothiazolinone 
     EXAMPLE 47 
     7-{2-[N-(2-phthalimidoethyl)amino]ethyl}benzothiazolinone 
     EXAMPLE 48 
     7-{2-[N-(2-phthalimidoethyl)-N-n-propylamino]ethyl}-benzothiazolinone 
     EXAMPLE 49 
     3-[4-{N-[2-(benzothiazolinon-7-yl)ethyl]amino}butyl]-2,4-dioxo-3-azaspiro[4.5]decane 
     EXAMPLE 50 
     3-[4-{N-[2-(benzothiazolinon-7-yl)ethyl]-N-n-propyl-amino}butyl]-2,4-dioxo-3-azaspiro[4.5]decane 
     EXAMPLE 51 
     3-[4-{N-[2-(benzothiazolinon-7-yl)ethyl]amino}butyl]-2,4-dioxo-3-azabicyclo[3.3.0]octane 
     EXAMPLE 52 
     7-[2-{N-[4-(4,4-dimethyl-2,6-dioxo-1-piperidyl)butyl]amino}ethyl]benzothiazolinone 
     EXAMPLE 53 
     7-[2-{N-[4-(4,4-dimethyl-2-oxo-1-piperidyl)butyl]amino}ethyl]benzothiazolinone 
     EXAMPLE 54 
     7-[2-{N-[4-(2-oxo-1-piperidyl)butyl]amino}ethyl]benzothiazolinone 
     EXAMPLE 55 
     4-Methyl-7-(4-aminobutyl)-2,3-dihydro-3-oxo-1,4-benzoxazine 
     Employing 4-methyl-7-(4-bromobutyl)-2,3-dihydro-3-oxobenzoxazine in Example 1 instead of 3-methyl-6-(2-bromoethyl)benzothiazolinone, the product of the title is obtained. 
     EXAMPLES 56 TO 67 
     Using the procedure described in Examples 2 to 13, but employing 7-(4-aminobutyl)-4-methyl-2,3-dihydro-3-oxobenzoxazine instead of 3-methyl-6-(2-bromoethyl)benzothiazolinone, the following are obtained: 
     EXAMPLE 56 
     4-Methyl-7-{4-[N-(4-phthalimidobutyl)amino]butyl}-2,3-dihydro-3-oxo-1,4-benzoxazine 
     EXAMPLE 57 
     4-Methyl-7-{4-[N-(4-phthalimidobutyl)-N-n-propylamino]butyl}-2,3-dihydro-3-oxo-1,4-benzoxazine 
     EXAMPLE 58 
     4-Methyl-7-{4-[N-(3-phthalimidopropyl)amino]butyl}-2,3-dihydro-3-oxo-1,4-benzoxazine 
     EXAMPLE 59 
     4-Methyl-7-{4-[N-(3-phthalimidopropyl)-N-n-propylamino]-butyl}-2,3-dihydro-3-oxo-1,4-benzoxazine 
     EXAMPLE 60 
     4-Methyl-7-{4-[N-(2-phthalimidoethyl)amino]butyl}-2,3-dihydro-3-oxo-1,4-benzoxazine 
     EXAMPLE 61 
     4-Methyl-7-{4-[N-(2-phthalimidoethyl)-N-n-propylamino]butyl}-2,3-dihydro-3-oxo-1,4-benzoxazine 
     EXAMPLE 62 
     3-[4-{N-[4-(4-methyl-2,3-dihydro-3-oxo-1,4-benzoxazin-7-yl)butyl]amino}butyl]-2,4-dioxo-3-azaspiro[4.5]decane 
     EXAMPLE 63 
     3-[4-{N-[4-(4-methyl-2,3-dihydro-3-oxo-1,4-benzoxazin-7-yl)butyl]-N-n-propylamino}butyl]-2,4-dioxo-3-azaspiro-[4.5]decane 
     EXAMPLE 64 
     3-[4-{N-[4-(4-methyl-2,3-dihydro-3-oxo-1,4-benzoxazin-7-yl)butyl]amino}butyl]-2,4-dioxo-3-azabicyclo[3.3.0]-octane 
     EXAMPLE 65 
     4-Methyl-7-[4-{N-[4-(4,4-dimethyl-2,6-dioxo-1-piperidyl)butyl]amino}butyl]-2,3-dihydro-3-oxo-1,4-benzoxazine 
     EXAMPLE 66 
     4-Methyl-7-[4-{N-[4-(4,4-dimethyl-2-oxo-1-piperidyl)butyl]amino}butyl]-2,3-dihydro-3-oxo-1,4-benzoxazine 
     EXAMPLE 67 
     4-Methyl-7-[4-{N-[4-(2-oxo-1-piperidyl)butyl]amino}-butyl]-2,3-dihydro-3-oxo-1,4-benzoxazine 
     EXAMPLES 68 TO 71 
     Employing as in Examples 14 to 17 4-methyl-7-(4-bromobutyl)-2,3-dihydro-3-oxo-1,4-benzoxazine as a starting material instead of 3-methyl-6-(2-bromoethyl)benzothiazolinone, the following is obtained: 
     EXAMPLE 68 
     4-Methyl-7-[4-(N-methyl-N-benzylamino)butyl]-2,3-dihydro-3-oxo-1,4-benzoxazine which on catalytic hydrogenation yields: 
     EXAMPLE 69 
     4-Methyl-7-[4-(N-methylamino)butyl]-2,3-dihydro-3-oxo-1,4-benzoxazine 
     EXAMPLE 70 
     4-Methyl-7-[4-(isopropylaminobutyl)-2,3-dihydro-3-oxo-1,4-benzoxazine 
     EXAMPLE 71 
     4-Methyl-7-[4-n-propylaminobutyl)-2,3-dihydro-3-oxo-1,4-benzoxazine 
     EXAMPLE 72 
     4-Methyl-7-[4-(N-methyl-N-cyanomethylamino)butyl]-2,3-dihydro-3-oxo-1,4-benzoxazine 
     Using the procedure described in Example 18, but replacing 3-methyl-6-[2-(N-methylamino)ethyl]benzothiazolinone by 4-methyl-7-[4-(N-methylamino)butyl]-2,3-dihydro-3-oxo-1,4-benzoxazine, the product of the title is obtained. 
     Using the procedure described in Examples 19 and 20 with the product of Example 72, the following are obtained: 
     EXAMPLE 73 
     4-Methyl-7-{4-[N-methyl-N-(2-aminoethyl)amino]butyl}-2,3-dihydro-3-oxo-1,4-benzoxazine 
     EXAMPLE 74 
     4-Methyl-7-[4-{N-methyl-N-[2-(para-tolylsulfonylamino)ethyl]amino}butyl]-2,3-dihydro-3-oxo-1,4-benzoxazine 
     EXAMPLE 75 
     4-Methyl-7-[4-{N-n-propyl-N-[3-(para-tolylsulfonylamino)propyl]amino}butyl]-2,3-dihydro-3-oxo-1,4-benzoxazine 
     Using the procedure described in Example 24, but replacing 3-methyl-6-(2-propylaminoethyl)benzothiazolinone by 4-methyl-7-(4-propylaminobutyl)-2,3-dihydro-3-oxo-1,4-benzoxazine, the product of the title is obtained. 
     EXAMPLE 76 
     4-Methyl-7-[4-{N-n-propyl-N-[4-(para-tolylsulfonylamino)butyl]amino}butyl]-2,3-dihydro-3-oxo-1,4-benzoxazine 
     Using the procedure described in Example 75, but replacing 1-chloro-3-bromopropane by 1-chloro-4-bromobutane, the product of the title is obtained. 
     EXAMPLE 77 
     7-(2-Aminoethyl)-3-oxo-2,3-dihydro-1,4-benzoxazine 
     In a 250-cm 3  ground-necked flask, 0.01 mol of 7-(2-bromoethyl)-3-oxo-2,3-dihydro-1,4-benzoxazine and 0.3 g of potassium iodide are dissolved in 30 cm 3  of dimethylformamide. 
     A stream of gaseous ammonia is bubbled into the solution to the point of saturation and a reflux condenser is fitted. The temperature is stabilized at 50° C. with an oil bath and the mixture is then left stirring magnetically for 72 hours. After cooling, the reaction mixture is evaporated on a water bath under vacuum. The residue is ground in distilled water acidified with 5% HCl solution, and then drained. The filtrate is recovered, washed with ethyl acetate and then alkalinized with 10% sodium hydroxide solution. It is extracted with chloroform, leaving the 2 phases agitating for 1/2 hour, and the organic phase is washed with distilled water and then dried over calcium chloride. The organic phase is evaporated on a water bath under vacuum, the residue is then taken up in absolute ethanol, a stream of gaseous HCl is bubbled through and the mixture is then evaporated to dryness on a water bath under vacuum. The product is dried and then recrystallized. 
     EXAMPLE 78 
     4-Methyl-7-(2-propylaminoethyl)-3-oxo-2,3-dihydro-1,4-benzoxazine 
     Using the procedure described in Preparation 9, but replacing 6-(2-bromoethyl)-3-oxo-2,3-dihydro-1,4-benzoxazine by 4-methyl-7-(2-bromoethyl)-3-oxo-2,3-dihydro-1,4-benzoxazine, the product of the title is obtained. 
     EXAMPLES 79 TO 90 
     Using the procedure described in Examples 2 to 13, but employing 7-(2-aminoethyl)-4-methyl-3-oxo-2,3-dihydro-1,4-benzoxazine instead of 3-methyl-6-(2-bromoethyl)benzothiazolinone, the following are obtained: 
     EXAMPLE 79 
     4-Methyl-7-{2-[N-(4-phthalimidobutyl)amino]ethyl}-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 80 
     4-Methyl-7-{2-[N-(4-phthalimidobutyl)-N-n-propylamino]ethyl}-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 81 
     4-Methyl-7-{2-[N-(3-phthalimidopropyl)amino]ethyl}-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 82 
     4-Methyl-7-{2-[N-(3-phthalimidopropyl)-N-n-propylamino]ethyl}-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 83 
     4-Methyl-7-{2-[N-(2-phthalimidoethyl)amino]ethyl}-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 84 
     4-Methyl-7-{2-[N-(2-phthalimidoethyl)-N-n-propylamino]ethyl}-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 85 
     3-[4-{N-[2-(4-methyl-3-oxo-2,3-dihydro-1,4-benzoxazin-7-yl)ethyl]amino}butyl]-2,4-dioxo-3-azaspiro[4.5]decane 
     EXAMPLE 86 
     3-[4-{N-[2-(4-methyl-3-oxo-2,3-dihydro-1,4-benzoxazin-7-yl)ethyl]-N-n-propylamino}butyl]-2,4-dioxo-3-azaspiro[4.5]decane 
     EXAMPLE 87 
     3-[4-{N-[2-(4-methyl-3-oxo-2,3-dihydro-1,4-benzoxazin-7-yl)ethyl]amino}butyl]-2,4-dioxo-3-azabicyclo[3.3.0]octane 
     EXAMPLE 88 
     4-Methyl-7-[2-{N-[4-(4,4-dimethyl-2,6-dioxo-1-piperidyl)-butyl]amino}ethyl]-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 89 
     4-Methyl-7-[2-{N-[4-(4,4-dimethyl-2-oxo-1-piperidyl)-butyl]amino}ethyl]-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 90 
     4-Methyl-7-[2-{N-[4(2-oxo-1-oxo1-piperidyl)-butyl]amino}-ethyl]-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 91 
     4-Methyl-7-[2-{N-propyl-N-cyanomethylamino}-ethyl]-3-oxo-2,3-dihydro-1,4-benzoxazine 
     Using the procedure described in Example 18, but replacing 3-methyl-6-[2-(N-methylamino)ethyl]benzothiazolinone by 4-methyl-7-[2-(N-propylamino)ethyl]-3-oxo-2,3-dihydro-1,4-benzoxazine, the product of the title is obtained. 
     Using the procedure described in Examples 19 and 20 with the product of Example 91, the following are obtained, respectively: 
     EXAMPLE 92 
     4-Methyl-7-{2-[N-propyl-N-(2-aminoethyl)amino]ethyl}-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 93 
     4-Methyl-7-[2-{N-propyl-N-[2-(para-tolylsulfonylamino)-ethyl]amino}ethyl]-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 94 
     4-Methyl-7-[2-{N-propyl-N-[3-(para-tolylsulfonylamino)-propyl]amino}ethyl]-3-oxo-2,3-dihydro-1,4-benzoxazine 
     Using the procedure described in Example 24, but replacing 3-methyl-6-(2-propylaminoethyl)benzothiazolinone by 4-methyl-7-(2-propylaminoethyl)-3-oxo-2,3-dihydro-1,4-benzoxazine, the product of the title is obtained. 
     EXAMPLE 95 
     4-Methyl-7-[2-{N-propyl-N-[4-(para-tolylsulfonylamino)-butyl]amino}ethyl]-3-oxo-2,3-dihydro-1,4-benzoxazine 
     Using the procedure described in Example 94, but replacing 1-chloro-3-bromopropane by 1-chloro-4-bromobutane, the product of the title is obtained. 
     EXAMPLE 96 
     6-(2-Aminoethyl)-3-oxo-2,3-dihydro-1,4-benzoxazine 
     In a 250-cm 3  ground-necked flask, 0.01 mol of 6-(2-bromoethyl)-3-oxo-2,3-dihydro-1,4-benzoxazine and 0.3 g of potassium iodide are dissolved in 30 cm 3  of dimethylformamide. 
     A stream of gaseous ammonia is bubbled into the solution to the point of saturation and a reflux condenser is fitted. The temperature is stabilized at 50° C. with an oil bath and the mixture is then left stirring magnetically for 72 hours. After cooling, the reaction mixture is evaporated on a water bath under vacuum. The residue is ground with distilled water acidified with 5% HCl solution, and then drained. The filtrate is recovered, washed with ethyl acetate and then alkalinized with 10% sodium hydroxide solution. It is extracted with chloroform, leaving the 2 phases agitating for 1/2 hour, and the organic phase is washed with distilled water and then dried over calcium chloride. The organic phase is evaporated on a water bath under vacuum, the residue is then taken up in absolute ethanol, a stream of gaseous HCl is passed through and the mixture is then evaporated to dryness on a water bath under vacuum. The product is dried and then recrystallized. 
     EXAMPLES 97 TO 109 
     Using the procedure described in Examples 2 to 13, but employing 6-(2-aminoethyl)-3-oxo-2,3-dihydro-1,4-benzoxazine instead of 3-methyl-6-(2-bromoethyl)benzothiazolinone, the following are obtained: 
     EXAMPLE 97 
     6-{2-[N-(4-phthalimidobutyl)amino]ethyl}-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 98 
     6-{2-[N-(4-phthalimidobutyl)-N-n-propylamino]ethyl}-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 99 
     6-{2-[N-(3-phthalimidopropyl)amino]ethyl}-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 100 
     6-{2-[N-(3-phthalimidopropyl)-N-n-propylamino]ethyl}-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 101 
     6-{2-[N-(2-phthalimidoethyl)amino]ethyl}-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 102 
     6-{2-[N-(2-phthalimidoethyl)-N-n-propylamino]ethyl}-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 103 
     3-[4-{N-[2-(3-oxo-2,3-dihydro-1,4-benzoxazin-6-yl)-ethyl]amino}butyl]-2,4-dioxo-3-azaspiro[4.5]decane 
     EXAMPLE 104 
     3-[4-{N-[2-(3-oxo-2,3-dihydro-1,4-benzoxazin-6-yl)-ethyl]-N-n-propylamino}butyl]-2,4-dioxo-3-azaspiro[4.5]decane 
     EXAMPLE 105 
     3-[4-{N-[2-(3-oxo-2,3-dihydro-1,4-benzoxazin-6-yl)-ethyl]amino}butyl]-2,4-dioxo-3-azabicyclo[3.3.0]octane 
     EXAMPLE 106 
     6-[2-{N-[4-(4,4-dimethyl-2,6-dioxo-1-piperidyl)butyl]-amino}ethyl]-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 107 
     6-[2-{N-[4-(4,4-dimethyl-2-oxo-1-piperidyl)butyl]amino}-ethyl]-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 108 
     6-[2-{N-[4-(2-oxo-1-piperidyl)butyl]amino}ethyl]-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 109 
     6-[2-(N-methyl-N-cyanomethylamino)ethyl]-3-oxo-2,3-dihydro-1,4-benzoxazine 
     Using the procedure described in Example 17, but replacing 3-methyl-6-[2-(N-methylamino)ethyl]benzothiazolinone by 6-[2-(N-methylamino)ethyl]-3-oxo-2,3-dihydro-1,4-benzoxazine, the product of the title is obtained. 
     Using the procedure described in Examples 18 and 19 with the product of Example 109, the following are obtained: 
     EXAMPLE 110 
     6-{2-[N-propyl-N-(2-aminoethyl)amino]ethyl}-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 111 
     6-[2-{N-propyl-N-[2-(para-tolylsulfonylamino)ethyl]amino}ethyl]-3-oxo-2,3-dihydro-1,4-benzoxazine 
     EXAMPLE 112 
     6-[2-{N-n-propyl-N-[3-(para-tolylsulfonylamino)propyl]-amino}ethyl]-3-oxo-2,3-dihydro-1,4-benzoxazine 
     Using the procedure described in Example 24, but replacing 3-methyl-6-(2-propylaminoethyl)benzothiazolinone by 6-(2-propylaminoethyl)-3-oxo-2,3-dihydro-1,4-benzoxazine, the product of the title is obtained. 
     EXAMPLE 113 
     6-[2-{N-n-propyl-N-[4-(para-tolylsulfonylamino)butyl]-amino}ethyl]-3-oxo-2,3-dihydro-1,4-benzoxazine 
     Using the procedure described in Example 112, but replacing 1-chloro-3-bromopropane by 1-chloro-4-bromobutane, the product of the title is obtained. 
     EXAMPLE 114 
     3-Methyl-6-[2-{N-[4-(3-oxo-2,3-dihydro-2-benzisothiazolyl 1,1-dioxide)butyl]amino}ethyl]benzothiazolinone 
     Replacing N-(4-bromobutyl)phthalimide in Example 2 by 3-oxo-2,3-dihydro-2-(4-bromobutyl)benisothiazole 1,1-dioxide, the product of the title is obtained. 
     EXAMPLE 115 
     3-Methyl-6-[2-{N-[4-(3-oxo-2,3-dihydro-2-benzisothiazolyl 1,1-dioxide)butyl]-N-n-propylamino}ethyl]benzothiazolinone 
     Using the procedure described in Example 3, but employing the product obtained in Example 114 instead of 3-methyl-6-{2-[N-(4-phthalimidobutyl)amino]ethyl}benzothiazolinone, the product of the title is obtained. 
     EXAMPLE 116 
     3-Methyl-6-[2-{N-[3-(3-oxo-2,3-dihydro-2-benzisothiazolyl 1,1-dioxide)propyl]amino}ethyl]benzothiazolinone PG,43 
     By replacing N-(4-bromobutyl)phthalimide in Example 2 by 3-oxo-2,3-dihydro-2-(3-bromopropyl)benzisothiazole 1,1-dioxide, the product of the title is obtained. 
     EXAMPLE 117 
     3-Methyl-6-[2-{N-[3-(3-oxo-2,3-dihydro-2-benzisothiazolyl 1,1-dioxide)propyl]-N-n-propylamino}ethyl]benzothiazolinone 
     Using the procedure described in Example 3, but employing the product obtained in Example 116 instead of 3-methyl-6-{2-[N-(4-phthalimidobutyl)amino]ethyl}benzothiazolinone, the product of the title is obtained. 
     EXAMPLE 118 
     3-Methyl-6-[2-{N-[2-(3-oxo-2,3-dihydro-2-benzisothiazolyl 1,1-dioxide)ethyl]amino}ethyl]benzothiazolinone 
     By replacing N-(4-bromobutyl)phthalimide in Example 2 by 3-oxo-2,3-dihydro-2-(2-bromoethyl)-benzisothiazole 1,1-dioxide, the product of the title is obtained. 
     EXAMPLE 119 
     3-Methyl-6-[2-{N-[2-(3-oxo-2,3-dihydro-2-benzisothiazolyl 1,1-dioxide)ethyl]-N-n-propylamino}ethyl]benzothiazolinone 
     Using the procedure described in Example 3, but employing the product obtained in Example 118 instead of 3-methyl-6-{2-[N-(4-phthalimidobutyl)amino]ethyl}benzothiazolinone, the product of the title is obtained. 
     EXAMPLE 120 
     3-Methyl-6-(4-aminobutyl)benzoxazolinone (hydrochloride) 
     Using the procedure described in Example 1, but replacing 3-methyl-6-(2-bromoethyl)benzothiazolinone by 3-methyl-6-(4-chlorobutyl)benzothiazolinone, 3-methyl-6-(4-aminobutyl)benzothiazolinone (hydrochloride) is obtained. 
     EXAMPLES 121 to 132 
     Using the procedure described in Examples 2 to 13, but replacing 3-methyl-6-(2-aminoethyl)benzothiazolinone by 3-methyl-6-(4-aminobutyl)benzoxazolinone of Example 120, the following are obtained: 
     EXAMPLE 121 
     3-Methyl-6-{4-[N-(4-phthalimidobutyl)amino]butyl}-benzoxazolinone 
     EXAMPLE 122 
     3-Methyl-6-{4-[N-(4-phthalimidobutyl)-N-n-propylamino]-butyl}benoxazolinone 
     EXAMPLE 123 
     3-Methyl-6-{4-[N-(3-phthalimidopropyl)amino]butyl}-benoxazolinone 
     EXAMPLE 124 
     3-Methyl-6-{4-[N-(3-phthalimidopropyl)-N-propylamino]butyl}-benoxazolinone 
     EXAMPLE 125 
     3-Methyl-6-{4-[N-(2-phthalimidoethyl)-N-n-propylamino]butyl}-benoxazolinone 
     EXAMPLE 126 
     3-Methyl-6-{4-[N-(2-phthalimidoethyl)amino]butyl}-benoxazolinone 
     EXAMPLE 127 
     3-[4-{N-[4-(3-methylbenzoxazolinon-6-yl)butyl]amino}-butyl]-2,4-dioxo-3-azaspiro[4.5]decane 
     EXAMPLE 128 
     3-[4-{N-[4-(3-methylbenzoxazolinon-6-yl)butyl]N-n-propylamino}butyl]-2,4-dioxo-3-azaspiro[4.5]decane 
     EXAMPLE 129 
     3-[4-{N-[4-(3-methylbenzoxazolinon-6-yl)butyl]amino}-butyl]-2,4-dioxo-3-azabicyclo[3.3.0]octane 
     EXAMPLE 130 
     3-Methyl-6-[4-{N-[4-(4,4-dimethyl-2,6-dioxo-1-piperidyl)-butyl]amino}butyl]benzoxazolinone 
     EXAMPLE 131 
     3-Methyl-6-[4-{N-[4-(4,4-dimethyl-2-oxo-1-piperidyl)butyl]amino}butyl]benzoxazolinone 
     EXAMPLE 132 
     3-Methyl-6-[4-{N-[4-(2-oxo-1-piperidyl)butyl]amino}-butyl]benzoxazolinone 
     EXAMPLES 133 to 144 
     Using the procedure described in Examples 2 to 13, but replacing 3-methyl-6-(2-aminoethyl)benzothiazolinone by 3-methyl-6-(2-aminoethyl)benzoxazolinone described in Application EP 110,781, the following are obtained: 
     EXAMPLE 133 
     3-Methyl-6-{4-[N-(4-phthalimidobutyl)amino]ethyl}-benzoxazolinone 
     EXAMPLE 134 
     3-Methyl-6-{4-[N-(4-phthalimidobutyl)-N-n-propylamino]ethyl}benzoxazolinone 
     EXAMPLE 135 
     3-Methyl-6-{4-[N-(3-phthalimidopropyl)amino]ethyl}benzoxazolinone 
     EXAMPLE 136 
     3-Methyl-6-{4-[N-(3-phthalimidopropyl)-N-propylamino]ethyl}benzoxazolinone 
     EXAMPLE 137 
     3-Methyl-6-{4-[N-(2-phthalimidoethyl)-N-n-propylamino]ethyl}benzoxazolinone 
     EXAMPLE 138 
     3-Methyl-6-{4-[N-(2-phthalimidoethyl)amino]ethyl}benzoxazolinone 
     EXAMPLE 139 
     3-[4-{N-[4-(3-methylbenzoxazolinon-6-yl)ethyl]amino}-butyl]-2,4-dioxo-3-azaspiro[4.5]decane 
     EXAMPLE 140 
     3-[4-{N-[4-(3-methylbenzoxazolinon-6-yl)ethyl]-N-n-propylamino}butyl]-2,4-dioxo-3-azaspiro[4.5]decane 
     EXAMPLE 141 
     3-[4-{N-[4-(3-methylbenzoxazolinon-6-yl)ethyl]amino}butyl]-2,4-dioxo-3-azabicyclo[3.3.0]octane 
     EXAMPLE 142 
     3-Methyl-6-[4-{N-[4-(4,4-dimethyl-2,6-dioxo-1-piperidyl)-butyl]amino}ethyl]benzoxazolinone 
     EXAMPLE 143 
     3-Methyl-6-[4-{N-[4-(4,4-dimethyl-2-oxo-1-piperidyl)-butyl]amino}ethyl]benzoxazolinone 
     EXAMPLE 144 
     3-Methyl-6-[4-{N-[4-(2-oxo-1-piperidyl)butyl]amino}-ethyl]benzoxazolinone 
     EXAMPLE 145 
     3-[4-{N-methyl-N-[2-(3-methylbenzothiazolinon-6-yl)-ethyl]amino}butyl]-2,4-dioxo-3-azaspiro[4.5]decane-hydrochloride 
     In a ground-necked flask surmounted by a reflux condenser, 10 -2  mol of 3-methyl-6-[2-(N-methylamino)ethyl]benzoxazolinone, obtained in Example 15, and 1.2×10 -2  mol of triethylamine are dissolved in acetone, and the mixture is brought to reflux for 15 minutes. 0.02 mol of N-(4-bromobutyl)-2,4-dioxo-3-azaspiro[4.5]-decane is added and refluxing is maintained for 24 hours. The precipitate formed is drained, the filtrate is evaporated to dryness, the residue is taken up with dilute hydrochloric acid solution, the acidic medium is washed with toluene and then, after alkalinization, the aqueous phase is extracted several times with chloroform. 
     The organic phases are combined and evaporated to dryness, the residue is taken up with anhydrous ether and the requisite amount of ethereal hydrogen chloride is added. The product is drained, dried and recrystallized. 
     Yield: 35% 
     Melting point: 173°-174° C. 
     Spectral characteristics: 
     Infrared: 1600-1680 cm -1  : νCO. 1750 cm -1  : νCO (SCON). 
     1H Nuclear Magnetic Resonance: 2.60 ppm, singlet: 4H 2(NCH 2  CO). 2.80 ppm, singlet: 3H (amine). 3.50 ppm, singlet: 3H (amide). 
     EXAMPLE 146 
     3-[4-{N-methyl-N-[2-(3-methylbenzothiazolinon-6-yl)-ethyl]amino}butyl]-2,4-dioxo-3-azabicyclo[3.3.0]octane hydrochloride 
     Using the procedure described in Example 145, but replacing N-(4-bromobutyl)2,4-dioxo-3-azaspiro[4.5]decane by N-(4-bromobutyl)-2,4-dioxo-3-azabicyclo-[3.3.0]octane, the product of the title is obtained. 
     Yield: 45% 
     Melting point: 130°-132° C. 
     Spectral characteristics: 
     Infrared: 1600-1700 cm -1  : νCO. 1760 cm -1  : νCO (SCON). 
     1H Nuclear Magnetic Resonance: 2.80 ppm, singlet: 3H (CH 3 ). 
     EXAMPLE 147 
     3-[4-{N-methyl-N-[4-(3-methylbenzothiazolinon-6-yl)-butyl]amino}butyl]-2,4-dioxo-3-azaspiro[4.5]decane hydrochloride 
     Using the procedure described in Example 145, but replacing 3-methyl-6-[2-(N-methylamino)ethyl]benzothiazolinone by 3-methyl-6-[4-(N-methylamino)butyl]-benzothiazolinone, obtained in Example 38, the product of the title is obtained. 
     EXAMPLE 148 
     3-[4-{N-methyl-N-[4-(3-methylbenzothiazolinon-6-yl)-butyl]amino}butyl]-2,4-dioxo-3-azabicyclo[3.3.0]octane hydrochloride 
     Using the procedure described in Example 146, but replacing 6-[2-(N-methylamino)ethyl]benzothiaoxazolinone by 6-[4-(N-methylamino)butyl]benzothiazolinone, the product of the title is obtained. 
     EXAMPLE 149 
     3-[3-{N-methyl-N-[2-(3-methylbenzothiazolinon-6-yl)ethyl]-amino}propyl]-2,4-dioxo-3-azabicyclo[4.5]decane hydrochloride 
     Using the procedure described in Example 145, but replacing N-(4-bromobutyl)-2,4-dioxo-3-azaspiro[4.5]decane by N-(3-bromopropyl)-2,4-dioxo-3-azaspiro[4.5]-decane, the product of the title is obtained. 
     EXAMPLE 150 
     3-[3-{N-methyl-N-[2-(3-methylbenzothiazolinon-6-yl)ethyl]amino}propyl]-2,4-dioxo-3-azabicyclo[3.3.0]octane hydrochloride 
     Using the procedure described in Example 146, but replacing N-(4-bromobutyl)-2,4-dioxo-3-azabicyclo[3.3.0]-octane by N-(3-bromopropyl)-2,4-dioxo-3-azabicyclo[3.3.0]octane, the product of the title is obtained. 
     PHARMACOLOGICAL STUDY OF THE COMPOUNDS OF THE INVENTION 
     EXAMPLE 151 
     In Vitro Affinity Test for 5-HT 1A , D 2  and α 2  Receptors 
     The in vitro affinity tests for 5-HT 1A , D 2  and α 2  receptors were carried out according to conventional binding techniques. 
     The results of these studies show that the compounds of the invention possess a K0.5 of the order of 10 -10  M with respect to 5-HT 1A  receptors. This very great affinity is complemented by a very great selectivity. In effect, the ratio of the 5-HT 1A  /D2 affinities is equal to 100. That of the 5-HT 1A  /α2 affinities is equal to 10 4 . 
     EXAMPLE 152 
     Acute Toxicity 
     The acute toxicity was assessed after oral administration of a dose of 650 mg.kg -1  to batches of 8 mice (26±2 grams). The animals were observed at regular intervals during the first day and daily during the two weeks following the treatment. 
     It is apparent that most of the compounds of the invention are completely non-toxic. Most of them cause no deaths after administration at a dose of 650 mg.kg -1 , and no disorders are generally observed after administration of this dose. 
     EXAMPLE 153 
     Study of Anxiolytic Activity--Pigeon Conflict Test 
     Six White Carneaux pigeons not previously used in experiments are trained to peck a Plexiglass key which is transilluminated by red or white lights. The response key is mounted on the front wall of the experimental chamber. The pigeons are brought to 85% of their normal weight before the beginning of the experiment, which is carried out using the method of successive approximations (Frester 1953). At the start, each peck of the key (illuminated with a red or white light) which exceeds a force of 0.15N permits access to a mixture of cereals via an automatic dispenser located under the key. After several days, the cereals are no longer delivered until the thirtieth peck on the key. When this response to the 30th strike is obtained, and when it occurs regularly, permitting the delivery of feed, the color of the light of the key is alternated every three minutes (from white to red and vice versa). The measurement of the level of response to the 30th strike remains operative during each light phase. 
     During this phase and throughout the experiment, a daily session is composed of 5 cycles of 3 minutes of each light sequence, these sequences being separated by a 30-second interval during which the luminous keys are extinguished and the responses have no effect. Consequently, a sequence lasts approximately 35 to 40 minutes. When these levels of responses are stable and indentical for each color during a period of 5 days (this requires 3 to 4 weeks), every 30th response in one of the colored phases simultaneously brings about a release of feed and a brief (200-millisecond) and moderate (1.3 mA) electric shock delivered by electrodes placed on the pubic pones. The level of reponses is reduced at first, then returns to the initial value. 
     The administration of the products of the invention is carried out after a stable level of response is obtained over a period of 5 days. 
     The intramuscular injection of the products of the invention at a dose of 0.3 mg/kg -1  brings about a significant increase in responses whether or not followed by electric shocks, demonstrating the anxiolytic activity of these products. 
     EXAMPLE 154 
     Pharmaceutical Compositions 
     Tablets intended for the treatment of conditions affecting the mind, containing 5 mg of 3-[4-{N-[2-(3-methylbenzothiazolinon-6-yl)ethyl]amino}butyl]-2,4-dioxo-3-azaspiro[4.5]decane. 
     
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Preparation formula for 1,000 tablets.                                    
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3-[4-{N-[2-(3-Methylbenzothiazolinon-6-yl)ethyl]                          
                            5 g                                           
amino-butyl]-2,4-dioxo-3-azaspiro[4.5]decane                              
Wheat starch                20 g                                          
Corn starch                 20 g                                          
Lactose                     65 g                                          
Magnesium stearate          2 g                                           
Silica                      1 g                                           
Hydroxypropylcellulose      2 g                                           
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     Tablets intended for the treatment of pain, containing 2,5 mg of 3-methyl-6-{2-[4-(3-trifluoromethyl-phenyl)-1-piperazinyl]ethyl}benzothiazolinone hydrochloride. 
     
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Preparation formula for 1,000 tablets                                     
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3-Methyl-6-{2-[4-(3-trifluoromethylphenyl)-1-piperazinyl]                 
                             2,5   g                                      
ethyl}benzothiazolinone hydrochloride                                     
Wheat starch                 15    g                                      
Corn starch                  15    g                                      
Lactose                      65    g                                      
Magnesium stearate           2     g                                      
Silica                       1     g                                      
Hydroxypropylcellulose       2     g                                      
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