Patent Publication Number: US-10779754-B2

Title: Glycemic health metric determination and application

Description:
This application claims the benefit of priority to U.S. Provisional Patent Appl. No. 61/428,066 titled “QUANTIFYING GLYCEMIC CONTROL USING LOG-SQUARE METRIC,” filed on Dec. 29, 2010, and U.S. Nonprovisional patent application Ser. No. 13/326,890 titled “GLYCEMIC HEALTH METRIC DETERMINATION AND APPLICATION,” filed on Dec. 15, 2011, both of which assigned to the assignee of claimed subject matter, and incorporated herein by reference in its entirety. 
    
    
     BACKGROUND 
     1. Field 
     Subject matter disclosed herein relates to techniques to determine a metric quantifying a glycemic health of a patient. 
     2. Information 
     The pancreas of a normal healthy person produces and releases insulin into the blood stream in response to elevated blood plasma glucose levels. Beta cells (β-cells), which reside in the pancreas, produce and secrete insulin into the blood stream as it is needed. If β-cells become incapacitated or die, which is a condition known as Type 1 diabetes mellitus (or in some cases, if β-cells produce insufficient quantities of insulin, a condition known as Type 2 diabetes), then insulin may be provided to a body from another source to maintain life or health. 
     Traditionally, because insulin cannot be taken orally, insulin has been injected with a syringe. More recently, the use of infusion pump therapy has been increasing in a number of medical situations, including for delivering insulin to diabetic individuals. For example, external infusion pumps may be worn on a belt, in a pocket, or the like, and they can deliver insulin into a body via an infusion tube with a percutaneous needle or a cannula placed in subcutaneous tissue. 
     To determine an appropriate therapy for treating a patient&#39;s diabetic conditions, a blood glucose concentration is typically measured using one or more techniques such as, for example, metered blood glucose measurements (e.g. using finger sticks) or continuous glucose monitoring from processing signals generated by a blood glucose sensor inserted into subcutaneous tissue. While contemporaneous measurements of blood glucose concentration may be an effective metric for determining an appropriate therapy for addressing an immediate condition (e.g., determining a size of an insulin bolus to be given to a patient), measurements of blood glucose alone do not necessarily provide an indication of a patient&#39;s glycemic health over a time period, for example. Other metrics for assessing a patients&#39; overall glycemic health may include a measurement of hemoglobin A1c (or HbA1c), which is one form of glycohemoglobin. Here, such a hemoglobin is irreversibly glycated at one or both N-terminal valine residues of a β-chain of hemoglobin A0. Glycation of hemoglobin in a patient is typically quantified as a percentage of total hemoglobin. 
     A strong relationship exists between hemoglobin A1c levels in a diabetes patient and risks of micro-vascular complications. Accordingly, hemoglobin A1c measurements have become an integral component of the treatment of diabetes patients. 
     SUMMARY 
     Briefly, example embodiments may relate to methods, systems, apparatuses, and/or articles, etc. for a method comprising: at a special purpose computing apparatus, computing a profile of a blood glucose concentration of a patient based, at least in part, on observations of said blood glucose concentration collected at a blood glucose monitoring device; applying a cost or loss function to said computed profile to compute a metric representative of a glycemic health of the patient, said cost or loss function being based, at least in part, on a log-square metric; and affecting a therapy applied to said patient based, at least in part, on said computed metric. The computed metric may comprise a unidimensional metric in a particular embodiment. In another embodiment, affecting the therapy may comprise setting a target blood glucose level or target blood glucose range of said patient based, at least in part, on the computed metric. In one alternative implementation, the method may further comprise triggering an alarm in response to said computed metric. 
     In another implementation, the blood glucose concentration profile may comprise an estimated probability distribution function. Alternatively, the blood glucose concentration profile may comprise a histogram of blood glucose concentration measurements. In yet another alternative, the blood glucose concentration profile may comprise blood glucose concentration measurements. In another implementation, the log-square metric has the form: 
     
       
         
           
             
               g 
               ⁡ 
               
                 ( 
                 x 
                 ) 
               
             
             = 
             
               
                 [ 
                 
                   log 
                   ⁡ 
                   
                     ( 
                     
                       x 
                       
                         G 
                         c 
                       
                     
                     ) 
                   
                 
                 ] 
               
               2 
             
           
         
       
     
     In another implementation, the computed metric may comprise a bi-dimensional metric, and the method may further comprise: applying a first portion of said loss or cost function to said blood glucose concentration profile to derive a hyperglycemia component of said computed metric; and applying a second portion of said loss or cost function to said blood glucose concentration to derive a hypoglycemia component of said computed metric. 
     In another implementation, the method further comprises: defining the blood glucose concentration profile for a recurring period; computing the metric based, at least in part, on the recurring period; and affecting the therapy for the recurring period in the future based, at least in part, on the computed metric. Here, the recurring period may comprise a time of day. Alternatively, the recurring period may comprise a day of week. In another embodiment, defining the blood glucose concentration profile for a recurring period further comprises computing the profile for the recurring period based on observations of said blood glucose concentration collected only during said recurring period. 
     In a particular implementation, affecting the therapy applied to said patient further comprises affecting a closed-loop insulin delivery system based, at least in part, on said computed metric. For example, affecting the closed-loop insulin delivery system may further comprise affecting periodic command based, at least in part, on the computed metric. 
     In another implementation, an apparatus may comprise one or more processors to: for a plurality of patients, determine an associated plurality of unidimensional metrics indicative of glycemic health of the patients, said unidimensional metrics being computed based, at least in part, on an application of a cost or loss function to profiles of blood glucose concentration of said patients; and rank the patients for treatment according to a triage policy based, at least in part, on the unidimensional metrics. In one alternative aspect, the apparatus may further comprise communication interface components to receive information from a communication network, the one or more processors further to: compute said unidimensional metrics based, at least in part, on messages received through said communication interface components from computing platforms co-located with said patients. In a particular implementation, the messages may comprise measurements of blood glucose concentration collected at glucose monitoring devices. Alternatively, the messages may comprise unidimensional metrics computed at the computing platforms co-located with the patients. 
     In another embodiment, an article comprises a non-transitory storage medium comprising machine-readable instructions stored thereon which are executable by a special purpose computing apparatus to: determine an associated plurality of unidimensional metrics indicative of glycemic health of the patients, the unidimensional metrics being computed based, at least in part, on an application of a cost or loss function to profiles of blood glucose concentration of the patients; and rank the patients for treatment according to a triage policy based, at least in part, on the unidimensional metrics. 
     In another embodiment, an article comprises a non-transitory storage medium comprising machine-readable instructions stored thereon which are executable by a special purpose computing apparatus to: compute a profile of a blood glucose concentration of a patient based, at least in part, on observations of the blood glucose concentration collected at a blood glucose monitoring device; apply a cost or loss function to the computed profile to compute a metric representative of a glycemic health of the patient, the cost or loss function being based, at least in part, on a log-square metric; and affect a therapy applied to the patient based, at least in part, on the computed metric. In a particular implementation, the instructions are executable by the special purpose computing apparatus to affect the therapy by generating commands in an infusion system. 
     In another embodiment, an article comprises a non-transitory storage medium comprising machine-readable instructions stored thereon which are executable by a special purpose computing apparatus to: for a plurality of patients, determine an associated plurality of unidimensional metrics indicative of glycemic health of the patients, the unidimensional metrics being computed based, at least in part, on an application of a cost or loss function to profiles of blood glucose concentration of said patients; and rank the patients for treatment according to a triage policy based, at least in part, on said unidimensional metrics. 
     In another implementation, an apparatus comprises: means for computing a profile of a blood glucose concentration of a patient based, at least in part, on observations of said blood glucose concentration; means for applying a cost or loss function to said computed profile to compute a metric representative of a glycemic health of the patient, the cost or loss function being based, at least in part, on a log-square metric; and means for affecting a therapy applied to said patient based, at least in part, on the computed metric. 
     In another embodiment, an apparatus comprises: for a plurality of patients, means for determining an associated plurality of unidimensional metrics indicative of glycemic health of the patients, said unidimensional metrics being computed based, at least in part, on an application of a cost or loss function to profiles of blood glucose concentration of the patients; and means for ranking the patients for treatment according to a triage policy based, at least in part, on the unidimensional metrics. 
     In another embodiment, a method comprises: at a special purpose computing apparatus, for a plurality of patients, determining an associated plurality of unidimensional metrics indicative of glycemic health of the patients, the unidimensional metrics being computed based, at least in part, on an application of a cost or loss function to profiles of blood glucose concentration of the patients, the profiles of blood glucose concentration being obtained for the patients under multiple predefined therapies; and ranking the predefined therapies based, at least in part, on the unidimensional metrics. In one particular implementation, the predefined therapies are defined, at least in part, by closed-loop system design features. 
     Other alternative example embodiments are described herein and/or illustrated in the accompanying Drawings. Additionally, particular example embodiments may be directed to an article comprising a storage medium including machine-readable instructions stored thereon which, if executed by a special purpose computing device and/or processor, may be directed to enable the special purpose computing device/processor to execute at least a portion of described method(s) according to one or more particular implementations. In other particular example embodiments, a sensor may be adapted to generate one or more signals responsive to a measured blood glucose concentration in a body while a special purpose computing device and/or processor may be adapted to perform at least a portion of described method(s) according to one or more particular implementations based upon the one or more signals generated by the sensor. 
    
    
     
       BRIEF DESCRIPTION OF THE FIGURES 
       Non-limiting and non-exhaustive features are described with reference to the following figures, wherein like reference numerals refer to like and/or analogous parts throughout the various figures: 
         FIG. 1  is table showing Spearman ranking coefficients according to an embodiment; 
         FIG. 2  is a plot of a profile of a blood glucose concentration laid over a cost or loss function according to an embodiment; 
         FIG. 3  is a plot of a probability density function on a logarithmic scale laid over a cost or loss function formulated as a log-square metric according to an embodiment; 
         FIG. 4  is a table of alternative cost or loss functions applicable to a blood glucose concentration profile for computing a metric indicative of glycemic health according to alternative embodiments; 
         FIG. 5  is a table of Spearman rank coefficients for use in balancing three hypoglycemic-biased metrics and three hyperglycemic-biased metrics for use in determining a cost or loss function according to an embodiment; 
         FIGS. 6( a ) through 6( d )  are plots illustrating application of a loss or cost function to blood glucose concentration profiles of a population of patients according to an embodiment; 
         FIG. 7  is a schematic diagram of a system for managing the glycemic health of multiple patients according to an embodiment; 
         FIG. 8  is a schematic diagram of an example closed loop glucose control system in accordance with an embodiment. 
         FIG. 9  is a front view of example closed loop hardware located on a body in accordance with an embodiment. 
         FIG. 10( a )  is a perspective view of an example glucose sensor system for use in accordance with an embodiment. 
         FIG. 10( b )  is a side cross-sectional view of a glucose sensor system of  FIG. 10( a )  for an embodiment. 
         FIG. 10( c )  is a perspective view of an example sensor set for a glucose sensor system of  FIG. 10( a )  for use in accordance with an embodiment. 
         FIG. 10( d )  is a side cross-sectional view of a sensor set of  FIG. 10( c )  for an embodiment. 
         FIG. 11  is a cross sectional view of an example sensing end of a sensor set of  FIG. 10( d )  for use in accordance with an embodiment. 
         FIG. 12  is a top view of an example infusion device with a reservoir door in an open position, for use according to an embodiment. 
         FIG. 13  is a side view of an example infusion set with an insertion needle pulled out, for use according to an embodiment. 
     
    
    
     DETAILED DESCRIPTION 
     As discussed above, contemporaneous measurements of a blood glucose concentration in a patient may be used for determining an insulin therapy for treating the patient&#39;s diabetic condition. Measurements of a blood glucose concentration may be useful in determining an insulin therapy for treating a diabetic&#39;s immediate condition. Measurements of blood glucose alone, however, may not completely characterize the patient&#39;s glycemic health, or take into consideration any possible long-term effects from application of a particular insulin therapy over a time period, for example. 
     In particular embodiments of insulin therapy infusion of insulin may be controlled so as to control/maintain a patient&#39;s blood glucose concentration at a target level or within a target range, thus reducing the risk that a patient&#39;s blood glucose level transition to dangerous extreme levels. Maintaining a patient&#39;s blood glucose concentration at a target level or within a target range may reduce the risk of hypoglycemia or hyperglycemia if a patient, non-medical professional or medical professional is not fully attentive to acting to affect a system for effective glycemic management. 
     Depending on a patient&#39;s particular physiology, a target or set-point glucose level may be established. For example, such a target or set-point glucose level may be defined based, at least in part, on guidelines established by the American Diabetes Association (ADA) and/or clinical judgment of a patient&#39;s physician. Here, for example, the ADA has recommended a pre-prandial blood glucose concentration of between 80-130 mg/dl, which is in the normal glycemic range. Alternatively, target or set-point glucose level may be fixed at 120 mg/dl, for example. In yet another alternative, a target or set-point blood glucose concentration may vary over time depending on particular patient conditions. It should be understood, however, that these are merely examples of a target or set-point blood glucose concentration, and claimed subject matter is not limited in this respect. 
     While techniques for establishing target level or target range for a patient&#39;s blood glucose concentration may consider immediate risks of a patient being in either a hypoglycemic or hyperglycemic state, these techniques typically do not consider longer-term effects of a patient being in a hypoglycemic or hyperglycemic state. As mentioned above, a concentration of hemoglobin A 1c  is typically used as a metric for glycemic health. However, concentration of hemoglobin A 1c  in a patient is correlated with central tendency (e.g., average) blood glucose concentration and not a statistical dispersion of blood glucose concentration (standard deviation). Concentration of hemoglobin A 1c  in a patient does not quantify an extent of exposure to glycemic variation (hypoglycemia and hyperglycemia). Other indicators indicative of or correlated with hypoglycemic or hyperglycemic conditions may include, for example, J-index, glycemic risk assessment diabetes equation (GRADE), M-value (e.g., using 100 mg/dl blood glucose concentration as an ideal), versions of the index of glycemic control (e.g., denoted in specific examples as IGC 1  and IGC 2  herein), coefficient of variation (CV), Kovatchev&#39;s low/high blood glucose index (LBGI, HBGI) and total risk index (RI=LBGI+HBGI), % Hypo (e.g., &lt;70 mg/dl), % Hyper (e.g., &gt;140 mg/dl), AUC below 70 mg/dl, AUC above 140 mg/dl, total AUC hypo , AUC hyper , AUC), interquartile range, and Cameron et al.&#39;s loss function. One or more of these metrics may be applied to a closed-loop glycemic management system as shown in Fraser Cameron, B. Wayne Bequette, Darrell M. Wilson, Bruce A. Buckingham, Hyunjin Lee, and Günter Niemeyer “A Closed-Loop Artificial Pancreas Based on Risk Management,” Journal of Diabetes Science and Technology, Volume 5, Issue 2, March 2011. From a virtual population of 10,000 patients, a distribution of 4,000 patient-months of data was collected, a table of Spearman&#39;s rank correlation coefficients was created as shown in  FIG. 1 . 
     As can be observed, some metrics are strongly correlated with hyperglycemia, including mean blood glucose concentration and A 1c . Mean blood glucose concentration and A 1c  metrics are also shown to be negatively correlated with hypoglycemia. Accordingly, use of such metrics to assess glycemic control in an insulin infusion therapy may lead to a tendency toward increased hypoglycemia and/or decreased hyperglycemia. Other metrics are strongly correlated with hypoglycemia and negatively correlated with hyperglycemia. As discussed below in a particular implementation, application of a log square cost function to a blood glucose concentration profile may lead to an insulin therapy providing an improved balance of the immediate risks of hypoglycemia and long-term risks of hyperglycemia. 
     In one aspect, particular embodiments described herein are directed to techniques for computing a metric enabling an improved control of insulin infusion so as to balance short-term risks and long-term risks associated with particular insulin therapies. In one particular embodiment, a technique for computing such a metric may comprise: characterizing a profile of a patient&#39;s blood glucose concentration; applying one or more cost or loss functions to the blood glucose concentration profile to provide a unidimensional value representative of glycemic health of the patient; and affecting a therapy applied to said patient based, at least in part, on the unidimensional value. In a particular embodiment, recognizing that a patient&#39;s blood glucose concentration may be roughly statistically distributed according to a lognormal distribution, a cost or loss function for application to a blood glucose concentration may be derived according to a log-square metric. 
     In one aspect, a unidimensional metric J may be computed as a convolution of a function representing a profile of a patient&#39;s blood glucose concentration with a cost or loss function to represent a patient&#39;s glycemic health in expression (1) as follows:
 
 J=∫   −∞   ∞   g ( x )f( x ) dx,   (1)
 
     where:
         x is a patient&#39;s blood glucose concentration;   f(x) is a function representing a profile of the patient&#39;s blood glucose concentration; and   g(x) is cost or loss function associated with the patient&#39;s blood glucose concentration being at level x.       

     It should be understood that expression (1) provides merely a single mathematical example of how a blood glucose concentration profile may be convolved with a loss or cost function for computing a unidimensional metric and that other implementations (e.g., in a special purpose computing apparatus programmed with instructions) may be employed without deviating from claimed subject matter. 
     Here, a unidimensional metric J may enable convenient assessment of a patient&#39;s health, and may allow for determination of an insulin infusion therapy that balances short-term and long-term risks of hypoglycemia and hyperglycemia. Here, a unidimensional metric may comprise a single value having a magnitude on a particular scale or range of values, such as a numerical value on a particular scale or range of numerical values. In one particular example, a unidimensional metric may be expressed as a percentage, a value normalized to a range between 0.0 and 1.0, etc. In a particular implementation, a value of J is an indication of glycemic health where a low value represents relatively good or normal glycemic health while a higher value represents poorer glycemic health. In particular implementations, f(x) may represent a patient&#39;s blood glucose profile over a longer time period (e.g., a month or longer) or just a few hours. 
     In one particular implementation, a f(x) may comprise a probability density function of a patient&#39;s blood glucose concentration which is determined or estimated using any one of several techniques. In particular example, a probability density function of patient&#39;s blood glucose concentration may be constructed from a histogram of blood glucose measurements taken over time using, for example, metered blood glucose reference samples or measurements obtained from a blood glucose sensor in a continuous blood glucose monitoring system. Alternatively, a probability density function of patient&#39;s blood glucose concentration may be modeled using any one of several functions used to model a biological process such as, for example, a normal distribution, lognormal distribution, just to name a couple of examples. Parameters for these models of a probability density function of patient&#39;s blood glucose concentration (e.g., mean, standard deviation) may be estimated from past observations of the patient&#39;s blood glucose concentration using well known techniques. 
     In another particular implementation, a patient&#39;s blood glucose concentration profile f(x) may represent actual measurements blood glucose concentration (e.g., from metered blood glucose measurements or sensor glucose measurements from a continuous glucose monitoring system) collected over a time period. 
       FIGS. 2 and 3  are example plots of a patient&#39;s blood glucose concentration laid over a loss or cost function that may be used to compute unidimensional metric J in particular embodiments. In this particular example,  FIG. 2 , represents the patient&#39;s blood glucose concentration profile as a probability density function in plot  102 . Plot  104  represents a quadratic loss or cost function. Here, plots  102  and  104  are shown in a linear domain. Plot  102  is indicative of a skewed probability density function which is not normal, and plot  104 , if applied as g(x) as shown above in relation (1), gives significantly more weight to hyperglycemia in computing metric J than it does to hypoglycemia. Alternatively, as illustrated in  FIG. 3 , plot  106  may represent a patient&#39;s blood glucose concentration as a lognormal probability density function. Plot  108 , representing a quadratic loss or cost function, may be applied against the blood glucose concentration profile of plot  106 . 
     To account for a skewed blood glucose concentration profile (e.g., represented as a skewed probability distribution of a patient&#39;s blood glucose concentration approaching a lognormal distribution as illustrated in  FIGS. 2 and 3 ,), a loss or cost function g(x) to be used in computing J in relation (1) may comprise a log-square metric form shown in expression (2) as follows: 
     
       
         
           
             
               
                 
                   
                     
                       g 
                       ⁡ 
                       
                         ( 
                         x 
                         ) 
                       
                     
                     = 
                     
                       
                         [ 
                         
                           log 
                           ⁡ 
                           
                             ( 
                             
                               x 
                               
                                 G 
                                 c 
                               
                             
                             ) 
                           
                         
                         ] 
                       
                       2 
                     
                   
                   , 
                 
               
               
                 
                   ( 
                   2 
                   ) 
                 
               
             
           
         
       
         
         
           
             Where G c  is a parameter that determines a local minimum or center of a curve in a linear scaled domain. 
           
         
       
    
     In a particular implementation, G c  may be selected to according to an optimization to balance Spearman rank coefficients with three hypoglycemic-biased metrics (% Hypo, LBGI and AUC hypo ) and three hyperglycemic-biased metrics (mean, % Hyper and HBGI). Using values shown in the particular example of the table shown in  FIG. 5 , a value of G c  is selected as 120 mg/dl. In other implementations, a value of G c  may be selected to balance different glycemic risks according to different metrics as shown as examples in Table 1 as follows: 
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 1 
               
               
                   
                   
               
               
                   
                 Metric 
                 Centering Value (G c ) 
                 Rank Correlation 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 A1c 
                 20 
                 mg/dl 
                 99% 
               
               
                   
                 GRADE 
                 40 
                 mg/dl 
                 100%  
               
               
                   
                 M-Value 
                 45 
                 mg/dl 
                 99% 
               
               
                   
                 Risk Index 
                 115 
                 mg/dl 
                 99% 
               
               
                   
                 Cameron et al. 
                 115 
                 mg/dl 
                 100%  
               
               
                   
                 AUC 
                 120 
                 mg/dl 
                 97% 
               
               
                   
                   
               
            
           
         
       
     
     It should be understood that the particular values for G c  and rank correlation are merely example values presented for the purpose of illustration, and that claimed subject matter is not limited to these particular values. For example, retrospective analysis, health care outcome analysis, clinician subjective assessments, randomized clinical trials, and other sources of data can be leveraged to develop more insight around determining an optimal value for G c  for a patient or group of patients, etc. 
     In a recent exercise eight key opinion leaders (KOLs, e.g., physicians and other clinicians) were asked to rank the order of priority in which they would prefer to see a group of five representative patients which having had their blood glucose concentration continuously monitored with blood glucose sensors. The data was shown to them first as the A 1c  and standard deviation of observed blood glucose concentration (SD). Then they were shown additional data including a probability distribution indicating a duration of time that measured blood glucose concentration remained below 70 mg/dl, between 70 and 140 mg/dl, and above 140 mg/dl. Finally, the KOLs where shown time series data for seven days of blood glucose sensor use for each patient.  FIGS. 6( c ) and 6( d )  show a representative population overlaid on quant plots for application of cost or loss function g(x) using a log-square metric according to expression (1), an isoquant for the 2.5-percentile equal to 70 mg/dl, an isoquant for the 97.5-percentile equal to 200 mg/dl, and contours for population distribution percentiles (25, 50, 75, and 97.5%). KOL rankings correlated well with the log-square metric (Spearman&#39;s rank correlation of 0.7). KOL rankings also indicated a bias to treat hypoglycemia first, giving a patient with a median glucose of almost 200 mg/dl the third place instead of the first place as a log-square ranking may indicate. The KOL ranking may reflect an urgency to treat the immediate threat of hypoglycemia, and not necessarily address the quality of glycemic control. Sustained hyperglycemia as exhibited by subject  3  in the KOL ranking indicates poor glycemic control (possibly leading to long-term health risks), but it does not imply an immediate threat to the patient&#39;s life (as with hypoglycemia). 
     Other alternative cost or loss functions applicable for g(x) in relation (1) are shown in the table of  FIG. 4 . It should be understood, however, that these are merely examples of functions that may provide a cost or loss function for application to a profile of a patient&#39;s blood glucose concentration in determining a metric representative of glycemic health, and claimed subject matter is not limited in this respect. 
       FIG. 7  is a schematic diagram of a system  50  comprising a computing environment according to an embodiment for use in determining and applying a unidimensional metric for indicating glycemic health. Computing platforms  52  may be communicatively coupled to computing platform  56  through network  58 . Computing platforms  52  and  56  may have communication interface components to facilitate communication with other devices through network  58  including, for example, modems network adapters and/or the like. Network  58  may comprise any one of several combinations of wired and wireless communication infrastructure including, for example, wired and wireless wide area network infrastructure and/or local area network infrastructure. In a particular implementation, network  58  may provide Internet protocol infrastructure to facilitate communication between computing platform  56  and computing platforms  52  in TCP/IP sessions, HTML, XML or other web service paradigms, for example. 
     Computing platforms  52  and  56  may comprise processors, memory, input/output devices, display devices, etc., to enable or support applications. For example, a memory may store instructions that are executable by a processor to perform one or more functions, tasks, processes, etc. In particular implementations, computing platforms  52  and  56  may comprise any one of several types of computing devices such as, for example, a server, personal computing, notebook computer, cell phone, smart phone, just to provide a few examples. Computing platforms  52  and  56  may comprise a graphical user interface (GUI) that facilitates user interaction with applications. 
     In a particular implementation, computing platforms  52  may be communicatively coupled (e.g., wired or wirelessly) to blood glucose monitoring device  54  to receive measurements of a patient&#39;s blood glucose concentration. Blood glucose monitoring device  54  may comprise a blood glucose meter capable of receiving blood glucose samples (e.g., from test strips). In another embodiment, blood glucose monitoring device  54  may comprise a blood glucose sensor and monitor for providing continuous blood glucose concentration measurements from processing signals from a blood glucose sensor as described below in a particular implementation with reference to  FIGS. 8 through 11 . 
     Computing platforms  52  may be coupled to corresponding blood glucose monitoring devices  54  using a wired or wireless link such as, for example, a universal serial bus, Bluetooth link, ultra wideband link, IEEE Std. 802.11 link, just to provide a few examples. In one example, a monitoring device  54  may comprise a memory (not shown) to store a history of blood glucose concentration measurements to be downloaded to a computing platform  52 . Alternatively, a blood glucose monitoring device  54  may forward blood glucose concentration measurements to a computing platform  52  as such blood glucose measurements are received in real-time. 
     In one implementation, system  50  may be located in a hospital environment where computing platforms  52  are co-located with patients at different locations communicate with a central computing platform  56  to centrally collect and process patient data. In another implementation, system  50  may be more geographically distributed in that central computing platform  50  may be located in doctor&#39;s office or medical clinic while computing platforms  52  are located in patients&#39; homes. Here, a unidimensional metric J may be computed for each patient to assess the patient&#39;s glycemic health. In one implementation, the centrally computed unidimensional metrics may allow for tailoring insulin therapies to the particular needs of the patients. In another implementation, the centrally computed unidimensional metrics may be incorporating in a process for triaging patients so that patients having the most severe conditions are treated with a priority over patients with least severe conditions. For example, patients with a higher computed unidimensional metric J may be treated with priority over patients with a lower computed unidimensional metric J. In another implementation, computing platforms  52  may have sufficient software program resources to compute a unidimensional metric J based, at least in part, on blood glucose measurements collected for a single patient at a blood glucose monitoring device  54  and without interaction with a central computing platform  56 . 
     In another embodiment, unidimensional metric J may be computed using a brief history of blood glucose measurements (e.g., over a three hour period) to obtain a snapshot of a patient&#39;s glycemic health. Here, a patient&#39;s glycemic health may be evaluated for different recurring conditions, time of day, time of week, etc. For example, a diabetic patient&#39;s dietary or exercise habits during typical week days may be different from the patient&#39;s dietary or exercise habits on the weekend, affecting the patient&#39;s glycemic health. It may be of interest, for example, to assess the patient&#39;s glycemic health on particular periodically repeating periods such as, for example, time of day (e.g., morning before first meal, afternoon following lunch time, in the evening before or after bedtime, etc.), day of week (e.g., Mondays following a weekend of altered exercise and dietary habits), time of month, time of year (e.g., during or following the holiday season), just to provide a few example of periodically repeating periods. 
     In one particular example, a unidimensional metric J to indicate glycemic health over a periodically repeating period may be computed based, at least in part, on a profile f(x) based, at least in part, on blood glucose concentration measurements as discussed above (e.g., either from metered blood glucose samples or from a blood glucose sensor in a continuous blood glucose monitoring system) collected over the periodically repeating period. For computing unidimensional metric J for Mondays, in a particular example, a patient&#39;s blood glucose concentration profile f(x) may comprise blood glucose concentration measurements collected over the 24-hour period on Mondays over multiple weeks. Similarly, for computing unidimensional metric J for a time of day (e.g., from 9 am to noon), a patient&#39;s blood glucose concentration profile f(x) may comprise blood glucose concentration measurements collected during this particular time over multiple days. Similarly, for computing unidimensional metric J for a time of year (e.g., holiday period from late November to early January), a patient&#39;s blood glucose concentration profile f(x) may comprise blood glucose concentration measurements collected during this time of the year over multiple years. Here, a patient&#39;s blood glucose concentration profile may be determined from blood glucose concentration measurements or observations limited to such measurements or observations obtained during the particular periodically repeating period of interest. 
     In one particular implementation, a blood glucose concentration profile f(x) characterizing blood glucose concentration for use in computing a metric may be expressed as follows:
         f(x)=f(x|ξ), where ξ represents a particular recurring condition or period of interest.       

     Here, ƒ(x|ξ) may represent a profile of a patient&#39;s blood glucose concentration profile based only on observations of the patient&#39;s blood glucose concentration obtained during recurring condition period ξ. For example, as discussed above, f(x|ξ) may comprise an estimated probability distribution or a histogram derived from observations of the patient&#39;s blood glucose concentration obtained during recurring condition period ξ, or merely measurements of the patient&#39;s blood glucose concentration obtained during recurring condition period ξ. 
     As discussed above, unidimensional metric J may be computed according to a cost or loss function g(x) so as to indicate a patient&#39;s glycemic health based, at least in part, on factors or risks indicative of hypoglycemia or hyperglycemia. Application of a particular cost or loss function g(x) as a log-square metric as shown in expression (2) may quantify effects of a blood glucose concentration being in a hypoglycemic or hyperglycemic region (e.g., being below or above G c ). While providing a convenient indicator of a patient&#39;s glycemic health, application of the log-square metric shown in expression (2) as loss or cost function g(x) in expression (1) to compute J, by itself, may not indicate whether a relatively high value for J (indicating a diminished glycemic health, for example) is brought about by hypoglycemia, hyperglycemia, or a mixture of hypoglycemic and hyperglycemic. 
     In one implementation, a “one sided” loss or cost function may be selectively applied for isolating and quantifying effects of hyperglycemia to the exclusion of effects of hypoglycemia, or quantifying effects of hypoglycemia to the exclusion of effects of hyperglycemia. Here, application of g(x) according to expression (3) below may isolate and quantify effects of hyperglycemia to the exclusion of effects of hypoglycemia: 
     
       
         
           
             
               
                 
                   
                     
                       
                         
                           
                             g 
                             ⁡ 
                             
                               ( 
                               x 
                               ) 
                             
                           
                           = 
                             
                           ⁢ 
                           
                             
                               [ 
                               
                                 log 
                                 ⁡ 
                                 
                                   ( 
                                   
                                     x 
                                     
                                       G 
                                       c 
                                     
                                   
                                   ) 
                                 
                               
                               ] 
                             
                             2 
                           
                         
                         , 
                         
                           
                             for 
                             ⁢ 
                             
                                 
                             
                             ⁢ 
                             x 
                           
                           ≥ 
                           
                             G 
                             c 
                           
                         
                       
                     
                   
                   
                     
                       
                         
                           = 
                             
                           ⁢ 
                           0 
                         
                         , 
                         
                           
                             for 
                             ⁢ 
                             
                                 
                             
                             ⁢ 
                             x 
                           
                           &lt; 
                           
                             
                               G 
                               c 
                             
                             . 
                           
                         
                       
                     
                   
                 
               
               
                 
                   ( 
                   3 
                   ) 
                 
               
             
           
         
       
     
     By convolving a patient&#39;s blood glucose concentration profile f(x) in expression (1) to compute metric J with g(x) as provided in a one-sided loss or cost function according to either expression (3), we can compute and quantify the effect of hyperglycemia in isolation. Similarly, application of g(x) according to expression (4) below may isolate and quantify effects of hypoglycemia to the exclusion of effects of hyperglycemia: 
     
       
         
           
             
               
                 
                   
                     
                       
                         
                           
                             g 
                             ⁡ 
                             
                               ( 
                               x 
                               ) 
                             
                           
                           = 
                             
                           ⁢ 
                           
                             
                               [ 
                               
                                 log 
                                 ⁡ 
                                 
                                   ( 
                                   
                                     x 
                                     
                                       G 
                                       c 
                                     
                                   
                                   ) 
                                 
                               
                               ] 
                             
                             2 
                           
                         
                         , 
                         
                           
                             for 
                             ⁢ 
                             
                                 
                             
                             ⁢ 
                             x 
                           
                           ≤ 
                           
                             G 
                             c 
                           
                         
                       
                     
                   
                   
                     
                       
                         
                           = 
                             
                           ⁢ 
                           0 
                         
                         , 
                         
                           
                             for 
                             ⁢ 
                             
                                 
                             
                             ⁢ 
                             x 
                           
                           &gt; 
                           
                             
                               G 
                               c 
                             
                             . 
                           
                         
                       
                     
                   
                 
               
               
                 
                   ( 
                   4 
                   ) 
                 
               
             
           
         
       
     
     By convolving a patient&#39;s blood glucose concentration profile f(x) in expression (1) to compute metric J with g(x) as provided in a one-sided loss or cost function according to either expression (4), we can compute and quantify the effect of hypoglycemia in isolation. While the particular examples of a one-sided loss or cost function in expressions (3) and (4) employ a log-square metric loss or cost function, it should be understood that such an application of a log-square metric is presented merely as an example, and that a one-sided loss or cost function may be derived from different expressions without deviating from claimed subject matter. 
     As discussed above, computation of unidimensional metric J may facilitate evaluation of a patient&#39;s glycemic health for different recurring conditions, time of day, time of week, etc. While convolving a patient&#39;s blood glucose concentration profile f(x) with cost or loss function g(x) according to relation (2) may identify recurring conditions, time of day, time of week, etc., where glycemic health is affected (e.g., as indicated by a high number for J over a period in question), this computation of J may not be indicative of either hyperglycemia or hypoglycemia. In one implementation, in periods or conditions under which a computed metric J indicates a decline in glycemic health for a particular blood glucose concentration profile f(x), the particular blood glucose concentration profile f(x) may be convolved again separately with one-sided loss or cost functions g(x) as set forth in expressions (3) and (4). The results of convolutions of f(x) separately with loss or cost functions g(x) as set forth in expressions (3) and (4) may be indicative of the effects of hyperglycemia in isolation and hypoglycemia, respectively. 
     In another implementation, a particular blood glucose concentration profile f(x) may be convolved separately with loss or cost functions g(x) as set forth in expressions (3) and (4) to provide a bi-dimensional metric indicative of the effects of hyperglycemia and hypoglycemia, separately, in two distinct dimensions. For example, two values J Hyper  and J Hypo , indicating glycemic health or risk in a hyperglycemia and hypoglycemia dimensions, respectively, may be computed using a log-square metric cost or loss function in expression (5) as follows: 
     
       
         
           
             
               
                 
                   
                     
                       
                         J 
                         Hyper 
                       
                       = 
                       
                         
                           ∫ 
                           
                             G 
                             c 
                           
                           ∞ 
                         
                         ⁢ 
                         
                           
                             
                               [ 
                               
                                 log 
                                 ⁡ 
                                 
                                   ( 
                                   
                                     x 
                                     
                                       G 
                                       c 
                                     
                                   
                                   ) 
                                 
                               
                               ] 
                             
                             2 
                           
                           ⁢ 
                           
                             f 
                             ⁡ 
                             
                               ( 
                               x 
                               ) 
                             
                           
                           ⁢ 
                           d 
                           ⁢ 
                           
                               
                           
                           ⁢ 
                           x 
                         
                       
                     
                     , 
                     and 
                   
                   ⁢ 
                   
                     
 
                   
                   ⁢ 
                   
                     
                       J 
                       Hypo 
                     
                     = 
                     
                       
                         ∫ 
                         
                           - 
                           ∞ 
                         
                         
                           G 
                           c 
                         
                       
                       ⁢ 
                       
                         
                           
                             [ 
                             
                               log 
                               ⁡ 
                               
                                 ( 
                                 
                                   x 
                                   
                                     G 
                                     c 
                                   
                                 
                                 ) 
                               
                             
                             ] 
                           
                           2 
                         
                         ⁢ 
                         
                           f 
                           ⁡ 
                           
                             ( 
                             x 
                             ) 
                           
                         
                         ⁢ 
                         d 
                         ⁢ 
                         
                             
                         
                         ⁢ 
                         
                           x 
                           . 
                         
                       
                     
                   
                 
               
               
                 
                   ( 
                   5 
                   ) 
                 
               
             
           
         
       
     
     While expression (5) applies a log-square loss or cost function, it should be understood that other loss or cost functions may be used without deviating from claimed subject matter. Separately identifying effects of hyperglycemic and hypoglycemic conditions contributing to glycemic health according to expression (5) may enable more effective therapies for managing a patient&#39;s glycemic health. As a discussed above, unidimensional metric J may be computed for a patient&#39;s blood glucose concentration profile f(x) over different recurring conditions, times of day, day of week, time of year, etc. Application of a one-sided loss or cost function g(x) (e.g., as in expression (3) or (4)) in computing J or application of a bi-dimensional metric may allow for further identification of how glycemic health is being effected in these different recurring conditions, times of day, day of week, time of year, etc. (e.g., by hypoglycemia or hypoglycemia). By identifying a patient as experiencing either hyperglycemia or hypoglycemia for a particular recurring condition, time of day, day of week, time of year, etc, a patient&#39;s therapy or behavior may be altered to address the particular hyperglycemic or hypoglycemic state. To counteract a particular hyperglycemic or hypoglycemic state for a particular recurring condition, for example, a patient may alter diet, exercise or insulin therapy (e.g., insulin infusion basal rate), or reduce stress, just to name a few examples. 
     In a particular implementation, a bi-dimensional metric may be used to adjust a patient&#39;s target blood glucose concentration level or range. For example, as described in U.S. patent application Ser. No. 12/820,944, filed on Jun. 22, 2010 and assigned to the assignee of claimed subject matter, a closed-loop blood glucose monitoring and insulin deliver system may establish a target blood glucose concentration level or target range. This target range may be adjusted upward, for example, if the patient is tending to be hypoglycemic for a particular recurring period, or adjusted downward if the patient is tending to be hyperglycemic. Such an adjustment of a target glucose level or target range may allow for a better balance of the immediate risks of a hypoglycemic condition with the longer-term risks of a hyperglycemic condition. 
       FIG. 8  is a block diagram of an example closed loop glucose control system  105  in accordance with an embodiment. Particular embodiments may include a glucose sensor system  110 , a controller  112 , an insulin delivery system  114 , and a glucagon delivery system  115 , etc. as shown in  FIG. 8 . In certain example embodiments, glucose sensor system  110  may generate a sensor signal  116  representative of blood glucose levels  118  in body  120 , and glucose sensor system  110  may provide sensor signal  116  to controller  112 . Controller  112  may receive sensor signal  116  and generate commands  122  that are communicated at least to insulin delivery system  114  and/or glucagon delivery system  115 . Insulin delivery system  114  may receive commands  122  and infuse insulin  124  into body  120  in response to commands  122 . Likewise, glucagon delivery system  115  may receive commands  122  from controller  112  and infuse glucagon  125  into body  120  in response to commands  122 . 
     Glucose sensor system  110  may include, by way of example but not limitation, a glucose sensor; sensor electrical components to provide power to a glucose sensor and to generate sensor signal  116 ; a sensor communication system to carry sensor signal  116  to controller  112 ; a sensor system housing for holding, covering, and/or containing electrical components and a sensor communication system; any combination thereof, and so forth. 
     Controller  112  may include, by way of example but not limitation, electrical components, other hardware, firmware, and/or software, etc. to generate commands  122  for insulin delivery system  114  and/or glucagon delivery system  115  based at least partly on sensor signal  116 . Controller  112  may also include a controller communication system to receive sensor signal  116  and/or to provide commands  122  to insulin delivery system  114  and/or glucagon delivery system  115 . In particular example implementations, controller  112  may include a user interface and/or operator interface (not shown) comprising a data input device and/or a data output device. Such a data output device may, for example, generate signals to initiate an alarm and/or include a display or printer for showing a status of controller  112  and/or a patient&#39;s vital indicators, monitored historical data, combinations thereof, and so forth. Such a data input device may comprise dials, buttons, pointing devices, manual switches, alphanumeric keys, a touch-sensitive display, combinations thereof, and/or the like for receiving user and/or operator inputs. It should be understood, however, that these are merely examples of input and output devices that may be a part of an operator and/or user interface and that claimed subject matter is not limited in these respects. 
     Insulin delivery system  114  may include an infusion device and/or an infusion tube to infuse insulin  124  into body  120 . Similarly, glucagon delivery system  115  may include an infusion device and/or an infusion tube to infuse glucagon  125  into body  120 . In alternative embodiments, insulin  124  and glucagon  125  may be infused into body  120  using a shared infusion tube. In other alternative embodiments, insulin  124  and/or glucagon  125  may be infused using an intravenous system for providing fluids to a patient (e.g., in a hospital or other medical environment). While an intravenous system is employed, glucose may be infused directly into a bloodstream of a body instead of or in addition to infusing glucagon into interstitial tissue. It should also be understood that certain example embodiments for closed loop glucose control system  105  may include an insulin delivery system  114  without a glucagon delivery system  115  (or vice versa). 
     In particular example embodiments, an infusion device (not explicitly identified in  FIG. 8 ) may include electrical components to activate an infusion motor according to commands  122 ; an infusion communication system to receive commands  122  from controller  112 ; an infusion device housing (not shown) to hold, cover, and/or contain the infusion device; any combination thereof; and so forth. 
     In particular example embodiments, controller  112  may be housed in an infusion device housing, and an infusion communication system may comprise an electrical trace or a wire that carries commands  122  from controller  112  to an infusion device. In alternative embodiments, controller  112  may be housed in a sensor system housing, and a sensor communication system may comprise an electrical trace or a wire that carries sensor signal  116  from sensor electrical components to controller electrical components. In other alternative embodiments, controller  112  may have its own housing or may be included in a supplemental device. In yet other alternative embodiments, controller  112  may be co-located with an infusion device and a sensor system within one shared housing. In further alternative embodiments, a sensor, a controller, and/or infusion communication systems may utilize a cable; a wire; a fiber optic line; RF, IR, or ultrasonic transmitters and receivers; combinations thereof; and/or the like instead of electrical traces, just to name a few examples. 
       FIGS. 9 through 13  illustrate example glucose control systems in accordance with certain embodiments.  FIG. 9  is a front view of example closed loop hardware located on a body in accordance with certain embodiments.  FIGS. 10( a )-10( d )  and  11  show different views and portions of an example glucose sensor system for use in accordance with certain embodiments.  FIG. 12  is a top view of an example infusion device with a reservoir door in an open position in accordance with certain embodiments.  FIG. 13  is a side view of an example infusion set with an insertion needle pulled out in accordance with certain embodiments. 
     Particular example embodiments may include a sensor  126 , a sensor set  128 , a telemetered characteristic monitor  130 , a sensor cable  132 , an infusion device  134 , an infusion tube  136 , and an infusion set  138 , any or all of which may be worn on a body  120  of a user or patient, as shown in  FIG. 9 . As shown in  FIGS. 10( a ) and 10( b ) , telemetered characteristic monitor  130  may include a monitor housing  131  that supports a printed circuit board  133 , battery or batteries  135 , antenna (not shown), a sensor cable connector (not shown), and so forth. A sensing end  140  of sensor  126  may have exposed electrodes  142  that may be inserted through skin  146  into a subcutaneous tissue  144  of a user&#39;s body  120 , as shown in  FIGS. 10( d )  and  11 . Electrodes  142  may be in contact with interstitial fluid (ISF) that is usually present throughout subcutaneous tissue  144 . 
     Sensor  126  may be held in place by sensor set  128 , which may be adhesively secured to a user&#39;s skin  146 , as shown in  FIGS. 10( c ) and 10( d ) . Sensor set  128  may provide for a connector end  27  of sensor  26  to connect to a first end  129  of sensor cable  132 . A second end  137  of sensor cable  132  may connect to monitor housing  131 . Batteries  135  that may be included in monitor housing  131  provide power for sensor  126  and electrical components  139  on printed circuit board  133 . Electrical components  139  may sample a current of sensor signal  116  (e.g., of  FIG. 8 ) to provide digital sensor values (Dsig) and store Dsig values in a memory. Digital sensor values Dsig may be periodically transmitted from a memory to controller  112 , which may be included in an infusion device. 
     In a particular implementation, controller  112  may perform additional filtering and processing on values for Dsig to compute continuous sensor blood glucose measurements as described in U.S. patent application Ser. No. 12/345,477, filed on Dec. 29, 2008, and Ser. No. 12/347,716, filed on Dec. 31, 2008, assigned to the assignee of claimed subject matter and incorporated herein by reference. These continuous blood glucose measurements may then be used for determining a patient&#39;s blood glucose concentration profile f(x) for use in computing unidimensional metric J as set forth in expression (1) above, for example. For example, these sensor blood glucose measurements may themselves be directly convolved with g(x) to produce J according to relation (1). Alternatively, sensor blood glucose measurements may be used to estimate parameters of a probability density function modeling a patient&#39;s blood glucose concentration. 
     With reference to  FIGS. 8, 9 and 12 , a controller  112  may process digital sensor values Dsig and generate commands  122  for infusion device  134 . Infusion device  134  may respond to commands  122  and actuate a plunger  148  that forces insulin  124  out of a reservoir  150  that is located inside an infusion device  134 . Glucose may be infused from a reservoir responsive to commands  122  using a similar and/or analogous device (not shown). In alternative implementations, glucose may be administered to a patient orally. 
     In particular example embodiments, a connector tip  154  of reservoir  150  may extend through infusion device housing  152 , and a first end  151  of infusion tube  136  may be attached to connector tip  154 . A second end  153  of infusion tube  136  may connect to infusion set  138  (e.g., of  FIGS. 9 and 13 ). Insulin  124  may be forced through infusion tube  136  into infusion set  138  and into body  116 . Infusion set  138  may be adhesively attached to a user&#39;s skin  146 . As part of infusion set  138 , a cannula  156  may extend through skin  146  and terminate in subcutaneous tissue  144  to complete fluid communication between a reservoir  150  and subcutaneous tissue  144  of a user&#39;s body  116 . 
     In one implementation, a unidimensional (e.g., J) or bi-dimensional metric (e.g., J Hypo  in combination with J Hyper ) may be used in real-time control of a closed-loop system (e.g., as shown in  FIG. 8 ) to provide insulin and/or glucagon. For example, a controller  112  may compute a control signal on a periodic basis to be used in formulating commands for a pump to infuse insulin and/or glucagon. Here, application of a unidimensional or bi-dimensional metric in formulating real-time commands in a closed loop system may allow for an improved balancing of the immediate risk of hypoglycemia and the long-term risks of hyperglycemia, for example. 
     In another example implementation, a unidimensional or bi-dimensional metric as discussed above may be used for triggering an alarm for a patient under certain conditions. As discussed above, during particular times of day, days of week, etc. a patient may be likely to encounter greater risks hyperglycemia or hypoglycemia than other times of day, days of week, etc. Under such a condition, an alarm signal may be triggered if a unidimensional or bi-dimensional metric as discussed above exceeds a threshold value. The alarm signal may initiate an audible or visual signal to cue the patient, or automatically initiate a change in therapy provided by a closed-loop system, for example. 
     In yet another example implementation, a unidimensional or bi-dimensional metric as discussed above may be used for performing optimization studies for the evaluation and design of control algorithms (e.g., control algorithms such as a closed-loop system for providing insulin and/or glucagon based, at least in part, on sensor glucose measurements. Here, a unidimensional or bi-dimensional metric may be conveniently computed over data sets covering large numbers individuals. The different therapies may then be ranked based upon an average value of J, for example. 
     In example alternative embodiments, as pointed out above, a closed-loop system in particular implementations may be a part of a hospital-based glucose management system. Given that insulin therapy during intensive care has been shown to dramatically improve wound healing and reduce blood stream infections, renal failure, and polyneuropathy mortality, irrespective of whether subjects previously had diabetes (See, e.g., Van den Berghe G. et al. NEJM 345: 1359-67, 2001), particular example implementations may be used in a hospital setting to control a blood glucose level of a patient in intensive care. In such alternative embodiments, because an intravenous (IV) hookup may be implanted into a patient&#39;s arm while the patient is in an intensive care setting (e.g., ICU), a closed loop glucose control may be established that piggy-backs off an existing IV connection. Thus, in a hospital or other medical-facility based system, IV catheters that are directly connected to a patient&#39;s vascular system for purposes of quickly delivering IV fluids, may also be used to facilitate blood sampling and direct infusion of substances (e.g., insulin, glucose, anticoagulants, etc.) into an intra-vascular space. 
     Moreover, glucose sensors may be inserted through an IV line to provide, e.g., real-time glucose levels from the blood stream. Therefore, depending on a type of hospital or other medical-facility based system, such alternative embodiments may not necessarily utilize all of the described system components. Examples of components that may be omitted include, but are not limited to, sensor  126 , sensor set  128 , telemetered characteristic monitor  130 , sensor cable  132 , infusion tube  136 , infusion set  138 , and so forth. Instead, standard blood glucose meters and/or vascular glucose sensors, such as those described in co-pending U.S. Patent Application Publication No. 2008/0221509 (U.S. patent application Ser. No. 12/121,647; to Gottlieb, Rebecca et al.; entitled “MULTILUMEN CATHETER”), filed 15 May 2008, may be used to provide blood glucose values to an infusion pump control, and an existing IV connection may be used to administer insulin to an patient. Other alternative embodiments may also include fewer, more, and/or different components than those that are described herein and/or illustrated in the accompanying Drawings. 
     Controller  112 , and computing devices  52  and  56  may comprise one or more processors capable of executing instructions to thereby render controller  112 , or computing devices  52  and  56  a special purpose computing device to perform algorithms, functions, methods, etc.; to implement attributes, features, etc.; and so forth that are described herein. Such processor(s) may be realized as microprocessors, digital signal processors (DSPs), application specific integrated circuits (ASICs), programmable logic devices (PLDs), controllers, micro-controllers, a combination thereof, and so forth, just to name a few examples. Alternatively, an article may comprise at least one storage medium (e.g., such as one or more memories) having stored thereon instructions  1706  that are executable by one or more processors. 
     Unless specifically stated otherwise, as is apparent from the preceding discussion, it is to be appreciated that throughout this specification discussions utilizing terms such as “processing”, “computing”, “calculating”, “determining”, “assessing”, “estimating”, “identifying”, “obtaining”, “representing”, “receiving”, “transmitting”, “storing”, “analyzing”, “measuring”, “detecting”, “controlling”, “delaying”, “initiating”, “providing”, “performing”, “generating”, “altering” and so forth may refer to actions, processes, etc. that may be partially or fully performed by a specific apparatus, such as a special purpose computer, special purpose computing apparatus, a similar special purpose electronic computing device, and so forth, just to name a few examples. In the context of this specification, therefore, a special purpose computer or a similar special purpose electronic computing device may be capable of manipulating or transforming signals, which are typically represented as physical electronic and/or magnetic quantities within memories, registers, or other information storage devices; transmission devices; display devices of a special purpose computer; or similar special purpose electronic computing device; and so forth, just to name a few examples. In particular example embodiments, such a special purpose computer or similar may comprise one or more processors programmed with instructions to perform one or more specific functions. Accordingly, a special purpose computer may refer to a system or a device that includes an ability to process or store data in the form of signals. Further, unless specifically stated otherwise, a process or method as described herein, with reference to flow diagrams or otherwise, may also be executed or controlled, in whole or in part, by a special purpose computer. 
     It should be understood that aspects described above are examples only and that embodiments may differ there from without departing from claimed subject matter. Also, it should be noted that although aspects of the above systems, methods, apparatuses, devices, processes, etc. have been described in particular orders and in particular arrangements, such specific orders and arrangements are merely examples and claimed subject matter is not limited to the orders and arrangements as described. It should additionally be noted that systems, devices, methods, apparatuses, processes, etc. described herein may be capable of being performed by one or more computing platforms. 
     In addition, instructions that are adapted to realize methods, processes, etc. that are described herein may be capable of being stored on a storage medium as one or more machine readable instructions. If executed, machine readable instructions may enable a computing platform to perform one or more actions. “Storage medium” as referred to herein may relate to media capable of storing information or instructions which may be operated on, or executed by, one or more machines (e.g., that include at least one processor). For example, a storage medium may comprise one or more storage articles and/or devices for storing machine-readable instructions or information. Such storage articles and/or devices may comprise any one of several media types including, for example, magnetic, optical, semiconductor, a combination thereof, etc. storage media. By way of further example, one or more computing platforms may be adapted to perform one or more processes, methods, etc. in accordance with claimed subject matter, such as methods, processes, etc. that are described herein. However, these are merely examples relating to a storage medium and a computing platform and claimed subject matter is not limited in these respects. 
     Although there have been illustrated and described what are presently considered to be example features, it will be understood by those skilled in the art that various other modifications may be made, and equivalents may be substituted, without departing from claimed subject matter. Additionally, many modifications may be made to adapt a particular situation to the teachings of claimed subject matter without departing from central concepts that are described herein. Therefore, it is intended that claimed subject matter not be limited to particular examples disclosed, but that such claimed subject matter may also include all aspects falling within the scope of appended claims, and equivalents thereof.