Patent Publication Number: US-10781246-B2

Title: Compositions and methods for anti-staphylococcal biologic agents

Description:
This application is a national stage application under 35 U.S.C. § 371 of PCT Application No. PCT/US2016/035931, filed Jun. 4, 2016, which claims the benefit of U.S. Provisional Patent Application Ser. No. 62/171,788, filed Jun. 5, 2015, which is hereby incorporated by reference in its entirety. 
    
    
     FIELD OF THE INVENTION 
     The present invention is directed to staphylococcal leukotoxin binding molecules and fusion constructs. The present invention is further directed to methods of treating, preventing, and diagnosing staphylococcal infection in a subject using the binding molecules and fusion constructs described herein. 
     BACKGROUND 
     Bacterial infections caused by  Staphylococcus  bacteria (i.e., a “staph infection”) are very common in the general population. About 25% of individuals commonly carry  Staphylococcus  bacteria on their skin or in their nose. Most of the time, these bacteria do not cause or problem or may cause a relatively minor skin infection. However, staph infections can turn deadly if the bacteria invade deeper into an individual&#39;s body, for example, entering the bloodstream, joints, bones, lungs or heart. In the past, a lethal staph infection might have occurred in a person who was hospitalized or had a chronic illness or weakened immune system. Now, it is increasingly common for an otherwise healthy individual to develop life-threatening staph infections. Importantly, many staph infections have become recalcitrant to antibiotic treatment due to infection with strains that exhibit true antibiotic resistance or reduced susceptibility to existing antibiotics. Such reductions in antibiotic effectiveness are typically more pronounced in patients with weakened immune systems due to immune senescence or immune compromization caused by co-morbidities or co-administered pharmaceutical agents or other medical procedures. 
       Staphylococcus aureus , often referred to as “staph,”  Staph. aureus ,” or “ S. aureus ,” is a major human pathogen, producing a multitude of virulence factors making it able to cause several types of infection, from superficial lesions to toxinoses and life-threatening systemic conditions such as endocarditis, osteomyelitis, pneumonia, meningitis and sepsis (reviewed in Miller and Cho, “Immunity Against  Staphylococcus aureus  Cutaneous Infections,”  Nat. Rev. Immunol.  11:505-518 (2011)). Although most individuals encounter  S. aureus  shortly after birth (Holtfreter et al., “Towards the Immune Proteome of  Staphylococcus aureus —The Anti- S. aureus  Antibody Response,”  Int. J. Med. Microbiol.  300:176-192 (2010)) and possess both antibodies against  S. aureus  and the ability to increase anti- S. aureus  titers after infection, these antibodies are often not protective against recurrent  S. aureus  infections (Foster TJ, “Immune Evasion by Staphylococci,”  Nat. Rev. Microbiol.  3:948-958 (2005)). In the United States alone, an annual mortality of more than 20,000 is attributed to methicillin-resistant  S. aureus  (MRSA), exceeding deaths caused by influenza, viral hepatitis, and HIV/AIDS (Foster, TJ., “Immune Evasion by Staphylococci,”  Nat. Rev. Microbiol.  3:948-958 (2005); Klevens et al., “The Impact of Antimicrobial-Resistant, Health Care-Associated Infections on Mortality in the United States,”  Clin. Infect. Dis.  47:927-930 (2008)). 
     The pathogen produces a variety of molecules that presumably facilitate survival in or on the human host. Bi-component, pore-forming leukotoxins are among the secreted virulence factors produced by  S. aureus . These toxins are secreted as water soluble monomers which oligomerize, and insert pores into the plasma membrane of host cells, most notably polymorphonuclear leukocytes (PMNs) and mononuclear phagocytes (Alonzo F. and Torres V., “ Staphylococcus aureus  Bi-component leukotoxins,”  Microbiol. Mol. Biol. Rev.  78(2): 199-230 (2014)). These pores disrupt cellular osmotic balance and membrane potential leading to death of the targeted cells. In the case of Leukotoxin ED (LukED), the targeting, binding, and killing of host phagocytic cells occurs via the cellular target CCR5, CXCR1 and CXCR2 located on the surface of the phagocytes (Alonzo III et al., “ Staphylococcus aureus  Leucocidin ED Contributes to Systemic Infection by Targeting Neutrophils and Promoting Bacterial Growth In Vivo,”  Mol. Microbiol.  83:423-435 (2012); Alonzo III et al. “CCR5 is a Receptor for  Staphylococcus aureus  Leukotoxin ED,”  Nature  493(7430)51-55 (2012); and Reyes-Robles et al., “ Staphylococcus aureus  Leukotoxin ED Targets the Chemokine Receptors CXCR1 and CXCR2 to Kill Leukocytes and Promote Infection,”  Cell Host  &amp;  Microbe  14:453-459 (2013)). Indeed, when the cellular target of LukED, CCR5, is not present on host immune cells, the host animal is resistant to the otherwise lethal  S. aureus  infection (Alonzo III et al. “CCR5 is a Receptor for  Staphylococcus aureus  Leukotoxin ED,”  Nature  493(7430):51-55 (2012)). In recent studies, the Duffy antigen receptor for chemokines (DARC) was also identified as a receptor for LukED and is necessary for LukED-mediated hemolysis of erythrocytes (Spaan et al., “ Staphylococcus aureus  Targets the Duffy Antigen Receptor for Chemokines (DARC) to Lyse Erythrocytes,” Cell Host &amp; Microbe 18(3): p. 363-370 (2015)). 
     Leukotoxin AB (LukAB) can also kill host phagocytic cells, and its cytolytic activity can be exerted both from the outside and the inside of the cell, i.e., after the microorganism is phagocytosed into the host cell (Dumont et al., “ Staphylococcus aureus  LukAB Cytotoxin Kills Human Neutrophils by Targeting the CD11b Subunit of the Integrin Mac-1 ,” PNAS  110(26):10794-10799 (2013)). Due to the contribution both of these leukotoxins have to pathogenesis, they have been considered critical  S. aureus  virulence factors (Alonzo III and Torres, “Bacterial Survival Amidst an Immune Onslaught: The Contribution of the  Staphylococcus aureus  Leukotoxins,”  PLOS Path  9(2):e1003143 (2013)). 
     Another critical factor for the pathogenic success of  S. aureus  depends on the properties of its surface proteins (Clarke et al., “Surface Adhesins of  Staphylococcus aureus,” Adv. Microb. Physiol.  51:187-224 (2006); Patti et al., “MSCRAMM-Mediated Adherence of Microorganisms to Host Tissues,”  Annu. Rev. Microbiol.  48:585-617 (1994); and Patti et al., “Microbial Adhesins Recognizing Extracellular Matrix Macromolecules,”  Curr. Opin. Cell Biol.  6:752-758 (1994)).  S. aureus  employs microbial surface components recognizing adhesive matrix molecules (MSCRAMMs) that adhere to and colonize host tissues via recognition of collagen, heparin-related polysaccharides, fibrinogen, and/or fibronectin of host cells.  S. aureus  expresses a subset of MSCRAMMs containing a serine-aspartate dipeptide repeat (SDR) domain, including clumping factor A (ClfA), clumping factor B (ClfB), SdrC, SdrD, and SdrE (Becherelli et al. “Protective Activity of the CnaBE3 Domain Conserved Among  Staphylococcus aureus  Sdr Proteins,”  PLoS One  8(9): e74718 (2013)).  S. epidermidis  also expresses three members of this family, SdrF, SdrG, and SdrH (McCrea et al., “The Serine-Aspartate Repeat (Sdr) Protein Family in  Staphylococcus Epidermidis,” Microbiology  146:1535-1546 (2000)). These proteins share a similar structure comprising an N-terminal ligand-binding A domain followed by the SDR domain, which contains between 25-275 serine-aspartate dipeptide repeats. The C-terminal portion of these proteins contains the LPXTG-motif, which facilitates cell wall anchoring by the transpeptidase sortase A. The serine-aspartate dipeptide regions in these proteins are modified by the sequential addition of glycans by two glycosyltransferases. First, SdgB appends N-acetylglucosamine (GlcNAc) on serine residues within the serine-aspartate dipeptide regions, followed by SdgA modification of the glycoprotein, resulting in disaccharide moieties. This glycosylation protects SDR-containing staphylococcal proteins from Cathepsin G-mediated degradation (Hazenbos et al., “Novel Staphylococcal Glycosyltransferases SdgA and SdgB Mediate Immunogenicity and Protection of Virulence-Associated Cell Wall Proteins,”  PLoS Pathog  9(10):e1003653 (2013)). 
     Protein A, located on the surface of  S. aureus , also contributes to staphylococcal escape from protective host immune responses by capturing the Fc domain of host IgG, as well as the Fab domain of the VH3 clan of IgG and IgM (Sjodahl et al., “Repetitive Sequences in Protein A from  Staphylococcus aureus . Arrangement of Five Regions Within the Protein, Four Being Highly Homologous and Fc-Binding,”  Eur. J. Biochem.  73:343-351 (1997); and Cary et al., “The Murine Clan V(H) III Related 7183, J606 and S107 and DNA4 Families Commonly Encode for Binding to a Bacterial B cell Superantigen,”  Mol. Immunol.  36:769-776 (1999)). In addition,  S. aureus  expresses a second immunoglobulin binding protein referred to as the second binding protein for immunoglobulins (Sbi) (Zhang et al., “A Second IgG-Binding Protein in  Staphylococcus aureus,” Microbiology  144:985-991 (1998) and Atkins et al., “ S. aureus  IgG-binding Proteins SpA and Sbi: Host Specificity and mechanisms of Immune Complex Formation,”  Mol. Immunol.  45:1600-1611 (2008)). Sbi is either secreted or associated with the cell envelope (Smith et al., “The Sbi Protein is a Multifunctional Immune Evasion Factor of  Staphylococcus aureus” Infection  &amp;  Immunity  79:3801-3809 (2011) and Smith et al., “The Immune Evasion Protein Sbi of  Staphylococcus aureus  Occurs both Extracellularly and Anchored to the Cell Envelope by Binding to Lipotechoic Acid”  Mol. Microbiol.  83:789-804 (2012)) and shares a pair of conserved helices with Protein A involved in binding to the Fc region of IgG proteins (Atkins et al., “ S. aureus  IgG-binding Proteins SpA and Sbi: Host Specificity and mechanisms of Immune Complex Formation,”  Mol. Immunol.  45:1600-1611 (2008)). Binding of IgGs to these proteins via the CH3 region of the Fc is thought to sequester antibodies on the cell surface of  S. aureus  in an orientation that prevents effective Fc-mediated opsonization of bacteria by neutrophils and therein serve as key immune evasion factors. 
       S. aureus  also secretes a number of proteases that have been implicated in immune evasion. Rooijakkers et al. demonstrated that  S. aureus  secretion of staphylokinase, a plasminogen activator protein, led to the activation of plasmin that cleaved both surface-bound IgG and complement C3b, ultimately reducing immune-mediated  S. aureus  destruction (Rooijakkers et al., “Anti-Opsonic Properties of Staphylokinase,”  Microbes and Infection  7:476-484 (2005)).  S. aureus  also secretes the serine protease glutamyl endopeptidase V8 (GluV8) that can directly cleave human IgG1 in the lower hinge region between E233 and L234 (EU numbering (Edelman et al., “The Covalent Structure of an Entire GammaG Immunoglobulin Molecule,”  PNAS  63:78-85 (1969), Brezski et al., “Human Anti-IgG1 Hinge Autoantibodies Reconstitute the Effector Functions of Proteolytically Inactivated IgGs,”  J. Immunol.  181:3183-3192 (2008)). It was also recently demonstrated that human anti- S. aureus  IgGs are rapidly cleaved when bound to the surface of  S. aureus  (Fernandez Falcon et al., “Protease Inhibitors Decrease IgG Shedding From  Staphylococcus aureus , Increasing Complement Activation and Phagocytosis Efficiency,”  J. Med. Microbiol.  60:1415-1422 (2011)). 
     Taken together, these studies indicate that  S. aureus  utilizes a number of mechanisms that could adversely affect standard IgG1-based monoclonal antibody (mAb) therapeutics, either by directly cleaving the mAb, sequestering of the mAb by Protein A or Sbi binding on the  Staph  cell surface, or by killing off the very effector cells required for therapeutic efficacy. It is therefore not surprising that presently there are no mAb-based therapies targeting  S. aureus  that have achieved final approval for use in humans. Thus, there remains a need for methods and compositions that can treat staphylococcal infection, which (i) evade protein A and Sbi binding, (ii) escape staph-induced proteolysis, (iii) can neutralize leukotoxins and (iv) are capable of opsonizing and delivering  S. aureus  to phagocytes. The present application meets these and other needs. 
     SUMMARY 
     A first aspect of the present disclosure is directed to a binding molecule comprising one or more modified fibronectin type III (FN3) domains, each modified FN3 domain having one or more loop regions that comprise one or more staphylococcal leukotoxin binding regions. 
     Another aspect of the present disclosure is directed to a binding molecule comprising one or more modified fibronectin type III (FN3) domains, each modified FN3 domain having one or more loop regions that comprise one or more staphylococcal hemolysin binding regions. 
     A second aspect of the present disclosure is directed to a fusion construct. The fusion construct comprises a first portion comprising one or more binding molecules described herein, and a second portion coupled to said first portion. The second portion of the fusion construct comprises a second binding molecule, a pharmaceutically active moiety, a prodrug, a pharmaceutically-acceptable carrier, a diagnostic moiety, a cell penetrating enhancer moiety, and/or a half-life extending modulating moiety. 
     Another aspect of the present disclosure is directed to a pharmaceutical composition comprising the binding molecules and/or fusion constructs as described herein. 
     Other aspects of the present disclosure are directed to methods of treating, preventing, and diagnosing a staphylococcal infection in a subject using the binding molecules, fusion constructs, and/or pharmaceutical compositions described herein. 
     Another aspect of the present disclosure is directed to a recombinant Leukocidin B (LukB) polypeptide comprising an amino acid sequence corresponding to amino acid residues 1-109 of SEQ ID NO: 1026 coupled to amino acid residues 152-305 of SEQ ID NO: 1026, where the LukB polypeptide does not comprise one or more amino acid residues corresponding to amino acid residues 110-151 of SEQ ID NO: 1026. 
     Another aspect of the present disclosure is directed to a recombinant Leukocidin A (LukA) polypeptide comprising an amino acid sequence corresponding to amino acid residues 1-134 of SEQ ID NO: 1018 coupled to amino acid residues 175-324 of SEQ ID NO: 1018, where the LukA polypeptide does not comprise one or more amino acid residues corresponding to amino acid residues 135-174 of SEQ ID NO: 1018. 
     Another aspect of the present disclosure is directed to a vaccine composition. The vaccine composition comprises a recombinant Leukocidin B (LukB) polypeptide comprising an amino acid sequence corresponding to amino acid residues 1-109 of SEQ ID NO: 1026 coupled to amino acid residues 152-305 of SEQ ID NO: 1026, wherein said LukB polypeptide does not comprise one or more amino acid residues corresponding to amino acid residues 110-151 of SEQ ID NO: 1026. The vaccine composition further comprises a recombinant Leukocidin A (LukA) polypeptide comprising an amino acid sequence corresponding to amino acid residues 1-134 of SEQ ID NO: 1018 coupled to amino acid residues 177-324 of SEQ ID NO: 1018, wherein said LukA polypeptide does not comprise one or more amino acid residues corresponding to amino acid residues 135-174 of SEQ ID NO: 1018. 
     The staphylococcal leukotoxin binding molecules described herein are small (about 10 kDa), simple, and highly stable single domain proteins that do not contain cysteine, disulfides or glycosylated residues. These molecules have excellent biophysical properties (e.g., greater than 100 mg/mL expression, greater than 170 mg/mL solubility, greater than 82° C. melting temperature, low predicted immunogenicity, and stable in serum for more than one month), and can be engineered for improved stability. Other advantages over conventional therapeutics include the ability to administer locally, orally, or a cross the blood-brain barrier, the ability to express in  E. coli  allowing for increased expression of protein as a function of resources versus mammalian cell expression, the ability to be engineered into bispecific molecules that bind to multiple targets or multiple epitopes of the same target, the ability to be conjugated to drugs, polymers, and probes, the ability to be formulated to high concentrations, and the ability of such molecules to effectively penetrate diseased tissues. Accordingly, the binding molecules described herein comprising one or more staphylococcal leukotoxin binding domains offer a unique therapeutic, prophylactic, and diagnostic approach to combatting staphylococcal infection. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIGS. 1A-1F  define a minimal epitope target for mAb 5133 and mAb 5133-FN3 fusion proteins.  FIGS. 1A, 1B, and 1C  show specific binding of mAb 5133 to the SdgB glycosylated form of SdrC4, ClfA, and ClfB, respectively.  FIG. 1D  shows mAb5133 binding to glycosylated streptavidin-bound SD peptide in a concentration dependent manner. The graph of  FIG. 1E  serves as a control showing that equivalent amounts of the glycosylated and non-glycosylated forms of the SD peptide are bound to the streptavidin-coated plates.  FIG. 1F  shows the binding of a series of mAb5133 fusion proteins to the glycosylated SD peptide. 
         FIGS. 2A-2C  depict target antigen engagement by mAb 5133 and mAb 5133-FN3 fusion proteins including simultaneous target engagement ( FIG. 2A ), target binding stoichiometry ( FIG. 2B ), and binding affinity ( FIG. 2C ). 
         FIGS. 3A-3D  show that target engagement by mAb 5133-FN3 fusion proteins can be altered by the length of linker coupling the mAb and FN3 portions of the fusion proteins.  FIG. 3A  shows variation in LukAB and LukE binding affinity due to changes in linker length.  FIG. 3B  is a matrix showing linker length mediated variation in fusion construct efficacy in a mouse model of  S. aureus  kidney infection.  FIGS. 3C and 3D  show the linker length-mediated variation in in vivo fusion protein binding to LukE ( FIG. 3C ) and LukAB ( FIG. 3D ) as well as linker length mediated variation in potential therapeutic efficacy for LukE ( FIG. 3C ) and LukAB ( FIG. 3D ) as measured by the number of colony forming units in a mouse model of  S. aureus  kidney infection. 
         FIGS. 4A-4C  show the correlation of toxin binding and neutralizing activity of a representative set of variants of three FN3 binding molecules containing LukE binding regions, i.e., Luk26 ( FIG. 4A ), Luk27 ( FIG. 4B ), and Luk38 ( FIG. 4C ). 
         FIG. 5  shows the correlation of toxin binding and neutralizing activity of a representative set of FN3 variants targeting leukotoxin LukAB. 
         FIG. 6  shows that the potential therapeutic efficacy of mAb 5133-FN3 fusion proteins is improved over mAb-5133 in a mouse kidney infection model. Therapeutic efficacy was determined by measuring the number of colony forming units (CFU) and assessing the presence of kidney abscess lesions. 
         FIGS. 7A-7B  are graphs showing that mAb 5133 and mAb 5133-FN3 fusion proteins exhibit enhanced therapeutic efficacy in a mouse renal abscess infection model over mAbs or mAb-FN3 fusion proteins targeting non-SDR adhesin protein antigens. 
         FIG. 8  is a graph showing that the efficacy of mAb5133 and mAb 5133-FN3 fusion proteins is enhanced in the presence of sub-therapeutic concentrations of vancomycin in a mouse kidney infection model. 
         FIG. 9  is a graph showing improved efficacy of mAb 5133-FN3 fusion proteins compared to mAb-5133 alone in a mouse bacteremia model. The top panel of  FIG. 9  shows the amount of colony forming units present in blood of mice infected with  S. aureus  and administered the identified antibody or antibody-FN3 fusion construct. The bottom panel of  FIG. 9  is depicts the amount of colony forming units present in the spleen of mice infected with  S. aureus  and administered the identified antibody or antibody-FN3 fusion construct. 
         FIG. 10  is a graph showing that the efficacy of mAb 5133-FN3 fusion proteins is improved over the sum of its composite parts in a mouse kidney infection model. 
         FIGS. 11A-11B  are graphs showing that the efficacy of mAb 5133-FN3 fusion proteins is improved over mAb-5133 in a mouse skin infection model as assessed by skin lesion volume ( FIG. 11A ) and bacterial burden in the skin lesion ( FIG. 11B ). 
         FIG. 12  is a graph showing that the mAb5133-FN3 fusion protein affords protection against  S. aureus  mediated extracellular cytolysis of primary human neutrophils. 
         FIG. 13  is a graph showing that the mAb5133-FN3 fusion protein affords protection against  S. aureus  mediated intracellular cytolysis of primary human neutrophils. 
         FIGS. 14A-14D  show that mAb5133-FN3 fusion proteins enhance opsonophagocytotic death of various  S. aureus  strains including, USA300 LAC ( FIG. 14A ), USA300 FRP, 18807, 18808, and 18809 ( FIG. 14B ), BK4645b (MSSA) ( FIG. 14C ), and USA500 BK2395 ( FIG. 14D ) in primary human neutrophils. 
         FIG. 15  shows the binding of a series of monoclonal antibodies to  S. aureus  protein A to exemplify binding via the Fc (Fragment, crystallizable) and/or Fab (fragment, antigen-binding) regions. 
         FIG. 16  is a graph showing that mAb5133-FN3 fusion proteins afford improved protection from LukAB-dependent extracellular killing of primary human neutrophils. 
         FIGS. 17A-17C  show that mAb5133-FN3 fusion proteins afford improved protection from extracellular killing of primary human neutrophils by non-cognate leukotoxin pairs LukE/LukF-PV and LukE/HlgB.  FIG. 17A  is a graph showing cytolytic activity of non-cognate leukotoxins LukE/LukF-PV and LukE/HlgB against primary human neutrophils. The top and bottom graphs of  FIG. 17B  show the relative activity of CNTO3930 and two mAb5133-FN3 fusion proteins in protecting primary human neutrophils from LukE/LukF-PV mediated cytolysis, as determined by the percent cell death (top graph) and release of LDH (bottom graph). The top and bottom graphs of  FIG. 17C  show the relative activity of CNTO3930 and two mAb5133-FN3 fusion proteins in protecting primary human neutrophils from LukE/HlgB mediated cytolysis, as determined by percent cell death (top graph) and the release of LDH (bottom graph). 
         FIGS. 18A-18B  demonstrate that mAb 5133-FN3 fusion proteins that bind LukE and neutralize the cytolytic activity that LukED exerts towards hPMNs, also neutralize the hemolytic activity of LukED on human erythrocytes.  FIG. 18A  shows a dose-dependent decrease in LukED mediated hemolysis with mAb5133-FN3 fusion protein treatment. The data is shown as percent hemolysis observed as compared to the 100% value observed with Triton X-100.  FIG. 18B  shows a dose-dependent decrease in LukED mediated hemolysis observed with mAb5133-FN3 fusion protein treatment. In this graph, the data is shown as percent hemolysis observed as compared to the 100% value observed with LukED treatment alone. 
         FIGS. 19A-19B  depict the interaction of a LukAB-specific FN3 protein (Luk17 FN3) with LukAB as determined by solution phase hydrogen/deuterium exchange (HDX)-Mass Spectrometry (MS).  FIG. 19A  is a differential heat map of LukB (SEQ ID NO: 11) resulting from HDX mapping in the presence or absence of the Luk17 FN3 protein. The LukB peptide regions,  260 IDWNRHGFWG 269  (amino acid residues 260-269 of SEQ ID NO: 11) and  201 LTRNGNLWAKDNFTPKDKMPVTVS 224  (amino acid residues 201-224 of SEQ ID NO: 11), identified in the map as Protected LukB peptide #1 and Protected LukB peptide #2, respectfully, contain residues of a LukAB neutralizing epitope bound by Luk17 FN3.  FIG. 19B  shows the localization of these linear sequences on a published, three-dimensional structure of LukAB as determined by X-ray crystallography (PDB entry 4tw1). 
         FIGS. 20A-20B  depict the identification of potential neutralization epitopes on leukocidin LukE by solution phase hydrogen/deuterium exchange (HDX)-Mass Spectrometry (MS).  FIG. 20A  is a differential heat map of LukE (SEQ ID NO: 1055) resulting from HDX mapping in the presence of absence of Luk26 FN3). The LukE peptide regions,  69 TSFSDVKGSGYELT 82  (amino acid residues 69-82 of SEQ ID NO: 1055) and  255 LFPRTGIYAERKHNAFVNRNF 275  (amino acid residues 255-275 of SEQ ID NO: 1055), and  244 YGRN 247  (amino acid residues 244-247 of SEQ ID NO: 1055) identified in the map as Major protected LukE peptides and Minor protected LukE peptides, respectively, contain residue of a LukE neutralizing epitope that is bound by Luk26 FN3.  FIG. 20B  shows the localization of these linear sequences on a published, three-dimensional structure of LukE as determined by X-ray crystallography. 
         FIGS. 21A-21F  depict the characterization of the neutralization epitope of the Luk17 FN3 protein on LukAB by x-ray crystallography.  FIG. 21A  shows the overall structure of the LukAB/S17/214F ternary complex as determined by X-ray crystallography. In this Figure LukA is shown in dark gray, LukB is shown in white, Fab214 is shown in light gray, and S17 is shown in black.  FIG. 21B  shows the alternate conformation of the pore-forming segments of LukA and LukB as determined for octameric and heterodimeric X-ray structures of LukAB. The left-hand portion of this figure is a structure overlay of LukB (white). The two A and B segments are colored black and dark gray in the dimer and octamer structures. The switch points for the two different conformations are identical.  FIG. 21C  shows the relative location of the Luk17 FN3 (S17) protein and Fab 214F binding sites on LukAB with respect to the membrane spanning segment in the LukAB octameric form. Shown is a structure of a composite of the LukAB/S17/214F structure and the LukAB octameric structure (PDB ID 4tw1). Binding of S17 and 214F is compatible with both dimer and octamer. The switching segments (dark gray) in the octamer form the inner pore whereas both S17 and 214F bind the exterior of the octamer.  FIG. 21D  shows minimal components of the LukAB neutralization epitope for the Luk17 FN3 protein as determined from the structure of the LukAB/S17/214F ternary complex, and the corresponding paratope of the Luk17 FN3 protein is shown in  FIG. 21E . Black underlined labels indicate residues for which mutations have most impact upon binding and the other black labels indicate residues with intermediate effects. Some epitope residues were not mutated or had minimal effect (gray label).  FIG. 21F  shows representational electron density at the LukB epitope/Luk17 FN3 paratope interface. The white labels in this Figure depict the S17 paratope residues while the black labels depict the LukB epitope residues. 
         FIGS. 22A-22B  depict the mutational mapping of LukB to confirm the neutralization epitope of the Luk17 FN3 protein.  FIG. 22A  shows the calculated affinity constant (K D ) and values for the Luk17 FN3 protein as determined by Bio-Layer Interferometry (BLI) for a series of site-directed substitution mutant variants of LukB. The amino acid number is per PDB ID#4tw1 (SEQ ID NO: 1026).  FIG. 22B  shows the calculated dissociation constant (K dis ) values for the Luk17 FN3 protein as determined by BLI for the same series of LukB variants. The amino acid number is per the sequence of PDB entry4tw1 (SEQ ID NO: 1026). 
         FIGS. 23A-23C  depict the mutational mapping of LukE to confirm the neutralization epitope of the Luk26 FN3 protein.  FIG. 23A  shows the calculated affinity constant (K D ) and values for the Luk26 FN3 protein as determined by BLI for a series of site-directed substitution mutant variants of LukE. The amino acid number is per PDB ID#3ROH (SEQ ID NO: 1054).  FIG. 23B  shows the calculated dissociation constant (K dis ) values for the Luk26 FN3 protein as determined by BLI for the same series of LukE variants. The amino acid number is per PDB ID#3ROH (SEQ ID NO: 1054).  FIG. 23C  shows the localization of residues that contribute to the LukED neutralization epitope for the Luk26 FN3 protein mapped on to the three-dimensional surface of a published high-resolution crystal structure of LukE. The amino acid number is per the sequence of PDB entry3ROH (SEQ ID NO: 1054). For clarity, an alignment of the LukED neutralization epitope regions within the recombinant LukE sequence used in the HDX mapping (Example 20; SEQ ID No: 1055), the recombinant LukE sequence used in the mutational analysis (Example 23; SEQ ID No: 1056), and the sequence of published LukE structure (PDB entry 3ROH; SEQ ID NO: 1054) is shown in  FIG. 23C . Note that the numbering of the SEQ ID NO: 1054 is based on Thr 30  being identified as the first residue for which electron density is apparent in the published LukE crystal structure (Nocadello et al., “Crystal structures of the components of the  Staphylococcus aureus  leukotoxin ED”  Acta. Cryst. D 72: 113-120 (2016), which is hereby incorporated by reference in its entirety; PDB entry 3roh). 
         FIGS. 24A-24C  define a further minimal epitope for mAb 5133 and characterize the interaction of mAB 5133 with N-acetyl-D-glucosamine as determined by x-ray crystallography.  FIG. 24A  shows the binding of mAb 5133 to a series of synthetic serine-aspartate (SD) repeat peptides with variable glycosylation characteristics as determined in an ELISA format assay.  FIG. 24B  shows a ribbon format structure of the complex of SM1B229 and GlcNAc. The SM1B229 heavy chain is shown in gray, the light chain is shown in white, and GlcNac is shown in black. Hydrogen bonding interactions are shown as dashed lines.  FIG. 24C  shows the electrostatic surface potential of the structure of the complex of SM1B229 and GlcNAc. The positive electrostatic surface potential shaded darker, and negative electrostatic surface potential shaded lighter. GlcNac is shown in white. The variable heavy (VH) region (amino acid residues 1-120 of SEQ ID NO: 1082) and variable light (VL) region (amino acid residues 1-107 of SEQ ID NO: 1083) of the SM1B229 are depicted beneath the structure. The underlined regions are the CDRs of each chain. CDR3 of the VH region (bold and underlined) forms a basic pocket for GlcNac binding. 
         FIG. 25  shows the binding of fibronectin type III (FN3) domain proteins and controls to  S. aureus  alpha hemolysin and human serum albumin as determined in an ELISA format assay. 
         FIGS. 26A-26D  depict the characterization of stem domain mutant variants of LukAB that retain the neutralization epitope of the FN3 domain protein Luk17.  FIG. 26A  shows the binding of a toxoid LukAB to Luk17-His-SA (SEQ ID NO: 1153) and TENCON-His-SA (SEQ ID NO: 1152) FN3 binding domain proteins as determined by Bio-Layer Interferometry (BLI).  FIG. 26B  shows the binding of the LukAB mut1  stem domain mutant variant to Luk17-His-SA and TENCON-His-SA FN3 binding domain proteins as determined by BLI.  FIG. 26C  shows the binding of the LukAB mut2  stem domain mutant variant to Luk17-His-SA and TENCON-His-SA FN3 binding domain proteins as determined by BLI.  FIG. 26D  shows the binding of the LukAB mut3  stem domain mutant variant to Luk17-His-SA and TENCON-His-SA FN3 binding domain proteins as determined by BLI. 
         FIGS. 27A-27I  demonstrate that anti-LukE FN3 domain proteins with extended serum exposure protect mice from lethal doses of leukotoxin LukED.  FIG. 27A  shows western blot analysis of the relative levels of FN3 domain proteins detected in sera from mice at two and twenty four hours after test article administration. No parental FN3 domain proteins are detected at either time point. In contrast, FN3 domain fusion proteins that exhibit an extended serum residence time (and therein exposure) are detected as full length proteins both two and twenty four hours after test article administration.  FIG. 27B  shows the relative protection observed with a series of FN3 domain proteins following administration of a lethal dose of LukED toxin to mice. Four hours post dosing, 100% protection is observed for the SAFN3-LukE26 fusion protein that bears an amino-terminal FN3 domain protein that binds serum albumin and a carboxyl terminal FN3 domain protein that binds LukED and neutralizes its cytolytic activity.  FIG. 27C  shows that this 100% protection is conserved on re-challenge of the SAFN3-LukE26 dosed animals 4.5 hours after the initial lethal intoxication challenge with LukED.  FIG. 27D  shows the relative protection observed with a series of FN3 domain proteins following administration of a lethal dose of LukED toxin to mice. Four hours post dosing, 100% protection is observed for the SABD-LukE26 fusion protein that bears an amino-terminal serum albumin binding domain and a carboxyl terminal FN3 domain protein that binds LukED and neutralizes its cytolytic activity.  FIG. 27E  shows that this 100% protection is conserved on re-challenge of the SABD-LukE26 dosed animals 4.5 hours after the initial lethal intoxication challenge with LukED.  FIG. 27F  shows the relative protection observed with a series of FN3 domain proteins following administration of a lethal dose of LukED toxin to mice. Four hours post dosing, 100% protection is observed for the TFFN3-LukE26 fusion protein that bears an amino-terminal FN3 domain protein that binds transferrin and a carboxyl terminal FN3 domain protein that binds LukED and neutralizes its cytolytic activity.  FIGS. 27G and 27H  show the relative activity of a series of FN3 domain proteins in neutralizing the ex vivo cytolytic activity of LukED against freshly prepared human PMNs as measure by LDH release ( FIG. 27G ) and cell death ( FIG. 27H ). As expected, neutralization of the cytolytic activity of LukED is observed with all FN3 domain proteins that contain the LukE26 entity. Finally,  FIG. 27I  shows the extent of protection of mice following administration of sequential lethal doses of the LukED leukocidin 5, 24 and 48 hours post dosing of SABD-Luk26 at a 1×, 10× and 100× molar ratio of SABD-Luk26 over LukED. 
     
    
    
     DETAILED DESCRIPTION 
     A first aspect of the present disclosure is directed to a binding molecule comprising one or more modified fibronectin type III (FN3) domains, where each modified FN3 domain has one or more loop regions that comprise one or more staphylococcal leukotoxin binding regions. 
     The FN3 domain is an evolutionary conserved protein domain that is about 100 amino acids in length and possesses a beta sandwich structure. The beta sandwich structure of human FN3 comprises seven beta-strands, referred to as strands A, B, C, D, E, F, G, with six connecting loops, referred to as loops AB, BC, CD, DE, EF, and FG that exhibit structural homology to immunoglobulin binding domains. Three of the six loops, i.e., loops DE, BC, and FG, correspond topologically to the complementarity determining regions of an antibody, i.e., CDR1, CDR2, and CDR3. The remaining three loops are surface exposed in a manner similar to antibody CDR3. In accordance with the present disclosure, one or more of the loop regions of each FN3 domain of the binding molecule are modified to comprise one or more staphylococcal leukotoxin binding regions. 
     The modified FN3 domain of the binding molecule of the present disclosure can be a FN3 domain derived from any of the wide variety of animal, yeast, plant, and bacterial extracellular proteins containing these domains. In one embodiment, the FN3 domain is derived from a mammalian FN3 domain. Exemplary FN3 domains include, for example and without limitation, any one of the 15 different FN3 domains present in human tenascin C, or the 15 different FN3 domains present in human fibronectin (FN) (e.g., the 10 th  fibronectin type III domain). Exemplary FN3 domains also include non-natural synthetic FN3 domains, such as those described in U.S. Pat. Publ. No. 2010/0216708 to Jacobs et al., which is hereby incorporated by reference in its entirety. Individual FN3 domains are referred to by domain number and protein name, e.g., the 3 rd  FN3 domain of tenascin (TN3), or the 10 th  FN3 domain of fibronectin (FN10). 
     In one embodiment, the FN3 domain of the binding molecule is derived from the non-naturally occurring FN3 domain of Tencon (SEQ ID NO: 1017). Tencon was designed from a consensus sequence of fifteen FN3 domains from human tenascin-C (Jacobs et al., “Design of Novel FN3 Domains With High Stability by a Consensus Sequence Approach,”  Protein Engineering, Design, and Selection  25:107-117 (2012), the disclosure of which is hereby incorporated by reference in its entirety). In another embodiment, the FN3 domain of the binding molecule is derived from the non-naturally occurring FN3 domain of Tencon-25 (SEQ ID NO: 1) as disclosed in Diem et al., “Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions,”  Protein Engineering, Design, and Selection  10:419-429 (2014), which is hereby incorporated by reference in its entirety). 
     Tencon domains, like other FN3 domains, have a beta-sandwich structure with the seven beta-strands, i.e., A, B, C, D, E, F, and G, linked by six loops, i.e., AB, BC, CD, DE, EF, and FG loops (Bork and Doolittle,  Proc. Natl. Acad. Sci. USA  89:8990-8992 (1992) and U.S. Pat. No. 6,673,901 to Koide et al., which are hereby incorporated by reference in their entirety). These loops span at or about amino acid residues 13-16 of SEQ ID NO: 1 (AB loop), amino acid residues 22-28 of SEQ ID NO: 1 (BC loop), amino acid residues 38-43 of SEQ ID NO:1 (CD loop), amino acid residues 51-54 of SEQ ID NO:1 (DE loop), amino acid residues 60-64 of SEQ ID NO: 1 (EF loop), and amino acid residues 75-81 of SEQ ID NO: 1 (FG loop). In accordance with the present disclosure, one or more of these loop regions or selected residues within one or more of these loop regions are modified for staphylococcal leukotoxin binding specificity and affinity. Suitable modifications include amino acid residue substitutions, insertions, and/or deletions. In one aspect, amino acid residues in at least one, at least two, at least three, at least four, at least five, or all six of the loop regions are altered for staphylococcal leukotoxin binding specificity and affinity. In one embodiment, one or more amino acid modifications within the loop regions at or about residues 22-28 (BC loop), 38-43 (CD loop), 51-54 (DE loop), and 75-81 (FG loop) of SEQ ID NO: 1 form the staphylococcal leukotoxin binding region. In another embodiment, one or more amino acid modification within the loop regions at or about residues 38-43 (CD loop) and 75-81 (FG loop) form the staphylococcal leukotoxin binding region. The modified one or more loop regions preferably interact with their target staphylococcal leukotoxin protein similar to an antibody CDR interaction with the protein. 
     As discussed above, FN3 domains contain two sets of CDR-like loops on the opposite faces of the molecule. The two sets of loops are separated by beta-strands that form the center of the FN3 structure. Like the loops, these beta-strands can be altered to enhance target molecule binding specificity and affinity. Preferably, some or all of the surface exposed residues in the beta strands are randomized without affecting (or minimally affecting) the inherent stability of the FN3 domain. One or more of the beta-strands can interact with a target protein. The beta-strands in a FN3 binding molecule provide a flat binding surface (compared to a curved binding surface found in protein scaffolds containing adjacent loops) that affects the target proteins, or specific epitopes on those target proteins, that can be bound effectively by the domain. In one aspect, at least a portion of one or more beta-strands of the FN3 domain is modified to interact with a staphylococcal leukotoxin protein. Suitable modifications include amino acid substitutions, insertions, and/or deletions. For example, one or more amino acid residues of the A beta strand (i.e., amino acid residues corresponding to residues 1-12 of SEQ ID NO: 1), the B beta strand (i.e., amino acid residues corresponding to residues 17-21 of SEQ ID NO: 1), the C beta strand (i.e., amino acid residues corresponding to residues 29-37 of SEQ ID NO: 1), the D beta strand (i.e., amino acid residues corresponding to residues 44-50 of SEQ ID NO: 1), the E beta strand (i.e., amino acid residues corresponding to residues 55-59 of SEQ ID NO: 1), the F beta strand (i.e., amino acid residues corresponding to residues 65-74 of SEQ ID NO: 1), or the G beta strand (i.e., amino acid residues corresponding to residues 82-89 of SEQ ID NO: 1) may be modified to generate staphylococcal leukotoxin binding domains or to enhance the specificity or affinity of leukotoxin binding. In one embodiment, one or more amino acid residues of the C beta strand and/or the F beta strand are modified for binding to a staphylococcal leukotoxin protein. 
     In one embodiment, the binding molecules of the present disclosure specifically bind to one or more staphylococcal leukotoxins, also referred to herein as staphylococcal leukocidins. Staphylococcal leukotoxins are a family bi-component toxins released by  S. aureus , which damage membranes of host defense cells and erythrocytes by the synergistic action of two non-associated proteins or subunits, i.e., the S-subunit and F-subunit (see Menestrina et al., “Mode of Action of Beta-Barrel Pore-Forming Toxins of the Staphylococcal Alpha-Hemolysin Family,”  Toxicol.  39(11):1661-1672 (2001). The binding molecules as described herein bind to one or more staphylococcal leukotoxins selected from leukotoxin A (LukA), leukotoxin B (LukB), leukotoxin AB (LukAB), leukotoxin D (LukD), leukotoxin E (LukE), leukotoxin ED (LukED), Panton-Valentine leukocidin S (LukS-PV), Panton-Valentine leukocidin F (LukF-PV), Panton-Valentine leukocidin (LukSF/PVL), gamma hemolysin A (HlgA), gamma hemolysin C (HlgC), gamma hemolysin B (HlgB), gamma hemolysin AB (HlgAB), and gamma-hemolysin BC (HlgBC). In one embodiment, the binding molecule binds to one or more of the staphylococcal leukotoxins selected from LukAB, LukD or LukE. In another embodiment, the binding molecules hereof are capable of specifically binding to a fragment of the above-mentioned proteins, where the fragment at least comprises a neutralizing epitope of the leukotoxin protein. Binding of the binding molecule of the present disclosure to a neutralizing epitope of the leukotoxin protein substantially or completely eliminates leukotoxin cytolytic and/or hemolytic activity. Neutralizing epitopes generally include regions of the leukotoxin protein involved in binding to a host cell membrane or receptor, regions of the leukotoxin protein involved in interacting with other leukotoxin proteins and oligomer formation, and regions of the leukotoxin protein involved in pore formation. The binding molecules of the present disclosure neutralize leukotoxin activity by at least 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 96%, 98%, 99%, or 100% when compared to leukotoxin activity in the absence of the binding molecule. 
     As used herein “specifically binds” or “specific binding” refers to the ability of the FN3 containing binding molecule of the disclosure to bind to a predetermined antigen, i.e., a staphylococcal leukotoxin with a dissociation constant (K D ) of about 1×10 −6  M or less, for example about 1×10 −7  M or less, about 1×10 −8 M or less, about 1×10 −9  M or less, about 1×10 −10 M or less, about 1×10 −11 M or less, about 1×10 −12 M or less, or about 1×10 −13  M or less. Typically the leukotoxin binding FN3 domain binds to its target leukotoxin(s) with a K D  that is at least ten fold less than its K D  for a nonspecific antigen (for example BSA or casein) as measured by surface plasmon resonance using for example a Proteon Instrument (BioRad). Thus, a monospecific, bispecific, or multispecific leukotoxin FN3 domain containing molecule as described herein specifically binds to each target leukotoxin with a binding affinity (K D ) of at least 1×10 −6  M or less. The isolated modified FN3 domain of the disclosure that specifically binds to a staphylococcal leukotoxin may, however, have cross-reactivity to other related bi-component toxins, for example to related S-subunit or F-subunit leukotoxins. 
     In one aspect, the binding molecule comprises a modified FN3 domain having one or more loop regions that comprise one or more LukE binding regions. This binding molecule is capable of binding a staphylococcal LukE protein having the amino acid sequence of SEQ ID NO: 1055 or fragments or homologs thereof. The LukE protein exemplified by SEQ ID NO: 1055 corresponds to the native mature LukE protein sequence modified to contain an N-terminal histidine tag. Accordingly, the amino acid residue at position 12 of SEQ ID NO: 1055 corresponds to the first amino acid residue of the mature LukE protein. 
     In one embodiment, binding of the LukE binding molecule to LukE effectively neutralizes LukE cytolytic and/or hemolytic activity, e.g., by inhibiting LukE and LukD interaction, inhibiting LukE binding to the plasma membrane of leukocytes, and/or inhibiting LukED pore formation. In accordance with this embodiment, the LukE binding molecule binds to one or more epitopes of LukE within a region of LukE comprising or consisting of amino acid residues corresponding to residues 22-33 of SEQ ID NO: 1055 (residues involved in LukE-LukD protein interaction), amino acid residues corresponding to residues 123-128 of SEQ ID NO: 1055 (residues involved in LukED membrane penetration), or amino acid residues corresponding to residues 137-142 of SEQ ID NO: 1055 (residues involved in LukED membrane penetration). In another embodiment, the LukE binding molecule binds to one or more epitopes of LukE within a region of LukE involved in LukE cell targeting. These regions comprise amino acid residues corresponding to residues 68-86 of SEQ ID NO: 1055, amino acid residues corresponding to residues 151-161 of SEQ ID NO: 1055, amino acid residues corresponding to residues 175-189 of SEQ ID NO: 1055, amino acid residues corresponding to residues 193-207 of SEQ ID NO: 1055, and amino acid residues corresponding to residues 248-278 of SEQ ID NO: 1055. As demonstrated in the Examples herein, amino acid residues 69-84 of SEQ ID NO: 1055 (corresponding to amino acid residues 86-101 of SEQ ID NO: 1054), and amino acid residues 252-275 of SEQ ID NO: 1055 (corresponding to amino acid residues 269-292 of SEQ ID NO: 1054) contain neutralizing epitopes of LukE. 
     In one embodiment, a LukE binding molecule as described herein comprises a C strand and a CD loop region having the amino acid sequence 
     DSFX 32 IX 34 YX 36 EX 38 X 39 X 40 X 41 X 42 E (SEQ ID NO: 993), where 
     X 32  is any amino acid residue, 
     X 34  is E or a functionally equivalent amino acid residue, 
     X 36  is any amino acid residue, 
     X 38  is any amino acid residue, 
     X 39  is W or a functionally equivalent amino acid residue, 
     X 40  is any amino acid residue, 
     X 41  is W or a functionally equivalent amino acid residue, 
     X 42  is any amino acid residue; 
     and an F strand and FG loop region having the amino acid sequence of TX 66 YX 68 VX 70 IX 72 GVKG X 77  X 78  X 79  SX 81  (SEQ ID NO: 994), where 
     X 66  is any amino acid residue, 
     X 68  is any amino acid residue, 
     X 70  is F or a functionally equivalent amino acid residue, 
     X 72  is G or a functionally equivalent amino acid residue, 
     X 77  is any amino acid residue, 
     X 78  is any amino acid residue, 
     X 79  is any amino acid residue, 
     X 81  is any amino acid residue. 
     In one embodiment, the LukE binding molecule as described herein comprises the a C strand and a CD loop region of SEQ ID NO: 993 and the F strand and FG loop region of SEQ ID NO: 994 as described above and binds to a neutralizing epitope of LukE in one of the regions of LukE noted above, i.e., amino acid residues 22-33, 123-128, 137-142, 68-86, 151-161, 175-189, 193-207, and 248-278 of SEQ ID NO:1055. 
     In another embodiment, the LukE binding molecule as described herein comprises the amino acid sequence of LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF X 32 I X 34 Y X 36 E X 38  X 39  X 40  X 41  X 42 EAI 
     X 46 LTVPGSERSYDLTGLKPGT X 66 Y X 68 V X 70 1 X 72 GVKG X 77  X 78  X 79  S X 81  X 82 L X 84 A 
     X 86 FTT (SEQ ID NO: 989), where 
     X 32  is any amino acid residue, 
     X 34  is E or a functionally equivalent amino acid residue, 
     X 36  is any amino acid residue, 
     X 38  is any amino acid residue, 
     X 39  is W or a functionally equivalent amino acid residue, 
     X 40  is any amino acid residue, 
     X 41  is W or a functionally equivalent amino acid residue, 
     X 42  is any amino acid residue, 
     X 46  is any amino acid residue, 
     X 66  is any amino acid residue, 
     X 68  is any amino acid residue, 
     X 70  is F or a functionally equivalent amino acid residue, 
     X 72  is G or a functionally equivalent amino acid residue, 
     X 77  is any amino acid residue, 
     X 78  is any amino acid residue, 
     X 79  is any amino acid residue, 
     X 81  is any amino acid residue, 
     X 82  is any amino acid residue, 
     X 84  is any amino acid residue, and 
     X 86  is any amino acid residue. 
     In accordance with this aspect, exemplary LukE binding molecules comprise any one of the amino acid sequences of SEQ ID NOs: 25 (Luk26) and 739-814. 
     In some embodiments, these LukE binding molecules comprise an initiator methionine residue linked to the N-terminus or a cysteine residue linked to the C-terminus to facilitate expression and/or conjugation to another moiety (e.g., another leukotoxin binding FN3 domain, a half-life extending moiety, or other therapeutic moiety). 
     In another embodiment, the LukE binding molecule as described herein binds LukE with one or more amino acid residues corresponding to residues E34, W39, W41, F70, and G72 of SEQ ID NO: 25 (Luk26). Accordingly, the FN3 domain binding molecule containing a LukE binding region comprises an amino acid sequence that is at least 70%, 75%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to the amino acid sequence of SEQ ID NO: 25, where residues E34, W39, W41, F70, and G72 of SEQ ID NO: 25 remain fixed or are substituted with functionally equivalent amino acid residues. 
     In another embodiment, a LukE binding molecule described herein comprises a C strand and a CD loop region having the amino acid sequence 
     DSFX 32 IX 34 YX 36 EX 38 X 39 X 40 X 41 GE (SEQ ID NO: 995) where 
     X 32  is any amino acid residue, 
     X 34  is any amino acid residue, 
     X 36  is any amino acid residue, 
     X 38  is W or a functionally equivalent amino acid residue, 
     X 39  is any amino acid residue, 
     X 40  is any amino acid residue, and 
     X 41  is any amino acid residue; 
     and an F strand and FG loop region having the amino acid sequence of TEYX 68 VX 70 IX 72 GVKGG X 78  X 79  SX 81  (SEQ ID NO: 996), where 
     X 68  is L or a functionally equivalent amino acid residue, 
     X 70  is D or a functionally equivalent amino acid residue, 
     X 72  is Y or a functionally equivalent amino acid residue, 
     X 78  is any amino acid residue, 
     X 79  is W or a functionally equivalent amino acid residue, and 
     X 81  is Y or a functionally equivalent amino acid residue. 
     In one embodiment, the LukE binding molecule as described herein comprises the a C strand and a CD loop region of SEQ ID NO: 995 and the F strand and FG loop region of SEQ ID NO: 996 as described above and binds to a neutralizing epitope of LukE in one of the regions of LukE noted above, i.e., amino acid residues 22-33, 123-128, 137-142, 68-86, 151-161, 175-189, 193-207, and 248-278 of SEQ ID NO:1055. 
     In one embodiment, the LukE binding molecule as described herein comprises the amino acid sequence of LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF X 32 I X 34 Y X 36 E X 38  X 39  X 40  X 41  GEAI VLTVPGSERSYDLTGLKPGT EY X 68 V X 70 1 X 72 GVKG G X 78  X 79  S X 81  PLSAIFTT (SEQ ID NO: 990) where, 
     X 32  is any amino acid residue, 
     X 34  is any amino acid residue, 
     X 36  is any amino acid residue, 
     X 38  is W or a functionally equivalent amino acid residue, 
     X 39  is any amino acid residue, 
     X 40  is any amino acid residue, 
     X 41  is any amino acid residue, 
     X 68  is L or a functionally equivalent amino acid residue, 
     X 70  is D or a functionally equivalent amino acid residue, 
     X 72  is Y or a functionally equivalent amino acid residue, 
     X 78  is any amino acid residue, 
     X 79  is W or a functionally equivalent amino acid residue, and 
     X 81  is Y or a functionally equivalent amino acid residue. 
     In accordance with this embodiment, exemplary LukE binding molecules include any one of the amino acid sequences of SEQ ID Nos: 26 (Luk27) and 815-827. In some embodiments, these LukE binding molecules comprise an initiator methionine residue linked to the N-terminus or a cysteine residue linked to the C-terminus to facilitate expression and/or conjugation to another moiety (e.g., another leukotoxin binding FN3 domain, a half-life extending moiety, or other therapeutic moiety). 
     In one embodiment, the LukE binding molecule as described herein binds LukE with one or more amino acid residues corresponding to residues W38, L68, D70, Y72, W79, and Y81 of SEQ ID NO: 26 (Luk27). Accordingly, the FN3 domain containing a LukE binding region comprises an amino acid sequence that is at least 70%, 75%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to the amino acid sequence of SEQ ID NO: 26, where residues W38, L68, D70, Y72, W79, and Y81 of SEQ ID NO: 26 remain fixed or are substituted with functionally equivalent amino acid residues. 
     In another embodiment, the LukE binding molecule described herein comprises a FG loop region having the amino acid sequence X 75  X 76  X 77  X 78  X 79  X 80 X 81  X 82  X 83  X 84  X 85  X 86  (SEQ ID NO: 997) where 
     X 75  is any amino acid residue, 
     X 76  is any amino acid residue, 
     X 77  is I or a functionally equivalent amino acid residue, 
     X 78  is any amino acid residue, 
     X 79  is any amino acid residue, 
     X 80  is G or a functionally equivalent amino acid residue, 
     X 81  is W or a functionally equivalent amino acid residue, 
     X 82  is L or a functionally equivalent amino acid residue, 
     X 83  is D or a functionally equivalent amino acid residue, 
     X 84  is F or a functionally equivalent amino acid residue, 
     X 85  is V or a functionally equivalent amino acid residue, and 
     X 86  is F or a functionally equivalent amino acid residue. 
     In one embodiment, the FG loop region of SEQ ID NO: 997 can contain one or more amino acid insertions. For example, amino acid insertions of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more amino acid residues can be made at or around positions X 75  and X 76  of SEQ ID NO: 997 or SEQ ID NO: 991. Likewise, amino acid insertions of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or more amino acid residues can be made at or around positions X 78  and X 79  of SEQ ID NO: 997 or SEQ ID NO: 991. 
     In one embodiment, the LukE binding molecule as described herein comprises the FG loop region of SEQ ID NO: 997 as described above and binds to a neutralizing epitope of LukE in one of the regions of LukE noted above, i.e., amino acid residues 22-33, 123-128, 137-142, 68-86, 151-161, 175-189, 193-207, and 248-278 of SEQ ID NO:1055. 
     In accordance with this embodiment, the LukE binding molecule as described herein comprises the amino acid sequence of LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFLIQYQESEKVGEAIVLTVPGSERSYDLTG LKPGTEYTVSIYGV X 75  X 76  X 77  X 78  X 79  X 80 X 81  X 82  X 83  X 84  X 85  X 86  SNPLSAIFTT (SEQ ID NO: 991), where 
     X 75  is any amino acid residue, 
     X 76  is any amino acid residue, 
     X 77  is I or a functionally equivalent amino acid residue 
     X 78  is any amino acid residue, 
     X 79  is any amino acid residue, 
     X 80  is G or a functionally equivalent amino acid residue 
     X 81  is W or a functionally equivalent amino acid residue 
     X 82  is L or a functionally equivalent amino acid residue, 
     X 83  is D or a functionally equivalent amino acid residue, 
     X 84  is F or a functionally equivalent amino acid residue, 
     X 85  is V or a functionally equivalent amino acid residue, and 
     X 86  is F or a functionally equivalent amino acid residue. 
     In accordance with this embodiment, exemplary LukE binding molecules comprise any one of the amino acid sequences of SEQ ID Nos: 37 (Luk38) and 828-839. In some embodiments, these LukE binding molecules comprise an initiator methionine residue linked to the N-terminus or a cysteine residue linked to the C-terminus to facilitate expression and/or conjugation to another moiety (e.g., another leukotoxin binding FN3 domain, a half-life extending moiety, or other therapeutic moiety). 
     In another embodiment, the LukE binding molecule as described herein binds LukE with one or more amino acid residues corresponding to residues 177, G80, W81, L82, D83, F84, V85, and F86 of SEQ ID NO: 37 (Luk38). In one embodiment, the FN3 domain containing a LukE binding region comprises an amino acid sequence that is at least 70%, 75%, 80%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to the amino acid sequence of SEQ ID NO: 37. 
     Additional exemplary LukE binding molecules are disclosed herein. Accordingly, an exemplary LukE binding molecule of the present disclosure comprises any one of the amino acid sequences of SEQ ID NOs: 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 113, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 155, 363, 364, 366, 367, 368, 369, 375, 376, 388, and 586, or an amino acid sequence that is at least 70%, 75%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to any one of the amino acid sequences of SEQ ID NOs: 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 113, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 155, 363, 364, 366, 367, 368, 369, 375, 376, 388, and 586. In some embodiments, these LukE binding molecules comprise an initiator methionine residue linked to the N-terminus or a cysteine residue linked to the C-terminus to facilitate expression and/or conjugation to another moiety (e.g., another leukotoxin binding FN3 domain, a half-life extending moiety, or other therapeutic moiety). 
     In another aspect, the binding molecule described herein comprises a FN3 domain having one or more modified loop regions that comprise one or more LukA and/or LukB binding regions. This binding molecule is capable of binding a LukA protein having the amino acid sequence of SEQ ID NO: 671 or a fragment or homolog thereof, and/or a LukB protein having the amino acid sequence of SEQ ID NO: 11 or a fragment or homolog thereof. In one embodiment, the binding molecule neutralizes LukAB activity, e.g., by inhibiting LukA and LukB interaction or by inhibiting LukAB binding to the host immune cells. In accordance with this embodiment, the binding molecule binds to one or more neutralizing epitopes of LukA and/or neutralizing epitopes of LukB. As described in more detail in the Examples herein, amino acid residues 201-224 and 260-269 of SEQ ID NO: 11 comprise regions of LukB that contain neutralizing epitopes. 
     In one embodiment, a LukAB binding molecule as described herein comprises a C strand and a CD loop region having the amino acid sequence DSFX 32 IX 34 YX 36 EX 38 X 39 X 40 X 41 X 42 E (SEQ ID NO: 998), where X 32  is W or a functionally equivalent amino acid residue, 
     X 34  is any amino acid residue, 
     X 36  is E or a functionally equivalent amino acid residue, 
     X 38  is K or a functionally equivalent amino acid residue, 
     X 39  is F or a functionally equivalent amino acid residue, 
     X 40  is Y or a functionally equivalent amino acid residue, 
     X 41  is R or a functionally equivalent amino acid residue, and 
     X 42  is any amino acid residue; 
     and an F strand and FG loop region having the amino acid sequence of TX 66 YX 68 VX 70 IX 72 GVKG X 77  X 78  X 79  SX 81  (SEQ ID NO: 999), where 
     X 66  is any amino acid residue, 
     X 68  is K or a functionally equivalent amino acid residue, 
     X 70  is W or a functionally equivalent amino acid residue, 
     X 72  is any amino acid residue, 
     X 77  is any amino acid residue, 
     X 78  is any amino acid residue, 
     X 79  is any amino acid residue, and 
     X 81  is W or a functionally equivalent amino acid residue. 
     In one embodiment, the LukAB binding molecule as described herein comprises the C strand and a CD loop region of SEQ ID NO: 998, and the F strand and FG loop region of SEQ ID NO: 999 as described above and binds to a neutralizing epitope of LukB in one of the regions of LukB identified above, i.e., amino acid residues 201-224 and/or 260-269 of SEQ ID NO:11. 
     In accordance with this embodiment, an exemplary LukAB binding molecule as described herein comprises the amino acid sequence of LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF X 32 I X 34 Y X 36 E X 38  X 39  X 40  X 41  X 42 EAI X 46 LTVPGSERSYDLTGLKPGTX 66 Y X 68 V X 70 1 X 72 GVKG X 77  X 78  X 79  S X 81  X 82 L X 84 A X 86 FTT (SEQ ID NO: 992), where 
     X 32  is W or a functionally equivalent amino acid residue, 
     X 34  is any amino acid residue, 
     X 36  is E or a functionally equivalent amino acid residue, 
     X 38  is K or a functionally equivalent amino acid residue, 
     X 39  is F or a functionally equivalent amino acid residue, 
     X 40  is Y or a functionally equivalent amino acid residue, 
     X 41  is R or a functionally equivalent amino acid residue, 
     X 42  is any amino acid residue, 
     X 42  is any amino acid residue, 
     X 46  is any amino acid residue, 
     X 66  is any amino acid residue, 
     X 68  is K or a functionally equivalent amino acid residue, 
     X 70  is W or a functionally equivalent amino acid residue, 
     X 72  is any amino acid residue, 
     X 77  is any amino acid residue, 
     X 78  is any amino acid residue, 
     X 79  is any amino acid residue, 
     X 81  is W or a functionally equivalent amino acid residue, 
     X 82  is any amino acid residue 
     X 84  is any amino acid residue, and 
     X 86  is any amino acid residue. 
     In accordance with this embodiment, exemplary LukAB binding molecules comprise any one of the amino acid sequences of SEQ ID Nos: 14 (Luk17) and 672-738. In some embodiments, these LukAB binding molecules comprise an initiator methionine residue linked to the N-terminus or a cysteine residue linked to the C-terminus to facilitate expression and/or conjugation to another moiety (e.g., another leukotoxin binding FN3 domain, a half-life extending moiety, or other therapeutic moiety). 
     In another embodiment, the LukAB binding molecule as described herein binds LukAB with one or more amino acid residues corresponding to residues W32, T34, E36, K38, F39, Y40, R41, A44, V46, E66, K68, W70, V72, W81, and P82 of SEQ ID NO: 14 (Luk17). In one embodiment, the FN3 domain containing a LukAB binding region comprises an amino acid sequence that is at least 70%, 75%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to the amino acid sequence of SEQ ID NO: 14, where amino acid residues W32, T34, E36, K38, F39, Y40, R41, A44, V46, E66, K68, W70, V72, W81, and P82 of SEQ ID NO: 14 remain fixed or are substituted with functionally equivalent amino acid residues. 
     Additional exemplary LukAB binding molecules are disclosed herein. Accordingly, an exemplary LukAB binding molecule of the present disclosure comprises any one of the amino acid sequences of SEQ ID NOs: 15, 16, 17, 145, 156, 158, 167, 214, 226, 247, 282, 286, 316, 370, 386, 388, 392, 446, 454, 462, 530, 540, 568, 574, 584, 587, 588, 589, 590, 591, 592, 593, 594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612, 613, 614, 615, 616, 617, 618, 619, 620, 621, 622, 623, 624, 625, 626, 627, 628, 629, 630, 631, 632, 633, 634, 635, 636, 637, 638, 639, 640, 641, 642, 643, 644, 645, 646, 647, 648, 649, 650, 651, 652, 653, 654, 655, 656, 657, 658, 659, 660, 661, 662, 663, 664, 665, 666 as well as an amino acid sequence that is at least 70%, 75%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to any one of the amino acid sequences of SEQ ID NOs: 15, 16, 17, 145, 156, 158, 167, 214, 226, 247, 282, 286, 316, 370, 386, 388, 392, 446, 454, 462, 530, 540, 568, 574, 584, 587, 588, 589, 590, 591, 592, 593, 594, 595, 596, 597, 598, 599, 600, 601, 602, 603, 604, 605, 606, 607, 608, 609, 610, 611, 612, 613, 614, 615, 616, 617, 618, 619, 620, 621, 622, 623, 624, 625, 626, 627, 628, 629, 630, 631, 632, 633, 634, 635, 636, 637, 638, 639, 640, 641, 642, 643, 644, 645, 646, 647, 648, 649, 650, 651, 652, 653, 654, 655, 656, 657, 658, 659, 660, 661, 662, 663, 664, 665, 666 In some embodiments, these LukAB binding molecules comprise an initiator methionine residue linked to the N-terminus or a cysteine residue linked to the C-terminus to facilitate expression and/or conjugation to another moiety (e.g., another leukotoxin binding FN3 domain, a half-life extending moiety, or other therapeutic moiety). 
     Another aspect of the present disclosure is directed to a binding molecule comprising one or more modified fibronectin type III (FN3) domains, where the modified FN3 domain contains one or more loop regions that comprise one or more staphylococcal hemolysin binding regions. In one embodiment, the binding molecule described herein comprises a FN3 domain having one or more modified loop regions that comprise one or more staphylococcal alpha-hemolysin (Hla) binding regions. This binding molecule is capable of binding an Hla protein having the amino acid sequence of SEQ ID NO: 1086 or fragments or homologs thereof. In one embodiment, the binding molecule neutralizes Hla activity, e.g., Hla mediated pore formation and cell death. In accordance with this embodiment, the binding molecule binds to one or more neutralizing epitopes of Hla. 
     In accordance with this embodiment, exemplary Hla binding molecules comprise any one of the amino acid sequences of SEQ ID Nos: 1097, 1099, 1112, 1142, and 1100, as well as amino acid sequences that are at least 70%, 75%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, or 99% identical to any one of the amino acid sequences of SEQ ID NOs: 1097, 1099, 1112, 1142, and 1100. In some embodiments, these Hla binding molecules comprise an initiator methionine residue linked to the N-terminus or a cysteine residue linked to the C-terminus to facilitate expression and/or conjugation to another moiety (e.g., another leukotoxin binding FN3 domain, a half-life extending moiety, or other therapeutic moiety). 
     In one embodiment, the binding molecule as disclosed herein is a monospecific binding molecule. In another embodiment, the binding molecule as disclosed herein is a bispecific binding molecule. A bispecific binding molecule of the present disclosure is a molecule comprising a first FN3 domain having a first staphylococcal leukotoxin binding region and a second FN3 domain having a second staphylococcal leukotoxin binding region that is distinct from the first staphylococcal leukotoxin binding region. In another embodiment, the binding molecule of the present disclosure is a multispecific binding molecule. A multispecific binding molecule as described herein is a molecule having at least a first, a second, and a third FN3 domain, each FN3 domain having a distinct staphylococcal leukotoxin binding region, i.e., the binding molecule comprises at least first, second, and third staphylococcal leukotoxin binding regions that are each distinct from each other. Bispecific and multispecific binding molecules as disclosed herein can be generated by covalently linking any first staphylococcal leukotoxin binding FN3 domain and any second or third or more staphylococcal leukotoxin binding FN3 domains directly or via a linker. Suitable linkers include peptides composed of repetitive modules of one or more of the amino acids, such as glycine and serine or alanine and proline. Exemplary linker peptides include, e.g., (Gly-Gly) n , (Gly-Ser) n , (Gly 3 -Ser) n , (Ala-Pro) n  whereinn is an integer from 1-25. The length of the linker may be appropriately adjusted as long as it does not affect the function of the binding molecule. The standard 15 amino acid (Gly 4 -Ser) 3  linker peptide has been well-characterized (e.g., within the context of an antibody single-chain Fv (scFv) domain) and has been shown to adopt an unstructured, flexible conformation. In addition, this linker peptide does not interfere with assembly and binding activity of the domains it connects (Freund et al., “Characterization of the Linker Peptide of the Single-Chain Fv Fragment of an Antibody by NMR Spectroscopy,”  FEBS  320:97 (1993), the disclosure of which is hereby incorporated by reference in its entirety). 
     In one embodiment, a bispecific binding molecule of the present disclosure comprises a first FN3 domain having a staphylococcal LukE binding region, e.g., any of the FN3 domain LukE binding regions described supra, coupled to a second FN3 domain having a different leukotoxin binding region. In one embodiment, the second FN3 domain comprises a LukAB binding region, e.g., any of the FN3 domain LukAB binding regions described supra. In one embodiment, the bi-specific binding molecule has a FN3 domain binding LukE that comprises an amino acid sequence of any one of SEQ ID NOs: 989, 990, or 991, and the FN3 domain binding LukAB that comprises an amino acid sequence of SEQ ID NO: 992. In another embodiment, the FN3 domain binding LukE comprises any one of the amino acid sequences selected from SEQ ID NOs: 25-59, 113,116-136, 155, 363, 364, 366-369, 375, 376, 388, 586, and 739-839, and the FN3 domain binding LukAB comprises any one of the amino acid sequences selected from SEQ ID NOs: 14, 15, 16, 17, 145, 156, 158, 167, 214, 226, 247, 282, 286, 316, 370, 386, 388, 392, 446, 454, 462, 530, 540, 568, 574, 584, 587-666 and 672-738. 
     The FN3 domains specifically binding a staphylococcal leukotoxin as described herein can be modified to improve their properties such as thermal stability and reversibility of thermal folding and unfolding. Several methods have been applied to increase the apparent thermal stability of proteins and enzymes, including rational design based on comparison to highly similar thermostable sequences, design of stabilizing disulfide bridges, mutations to increase alpha-helix propensity, engineering of salt bridges, alteration of the surface charge of the protein, directed evolution, and composition of consensus sequences (Lehmann and Wyss,  Curr Opin Biotechnol,  12: 371-375 (2001), which is hereby incorporated by reference in its entirety). High thermal stability may increase the yield of the expressed protein, improve solubility or activity, decrease immunogenicity, and minimize the need of a cold chain in manufacturing. Residues that can be substituted to improve thermal stability of Tencon (SEQ ID NO: 1017) or Tencon 25 (SEQ ID NO: 1) include, without limitation, residues at positions 11, 14, 17, 37, 46, 73, or 86, and are described in U.S. Patent Publication No. 2011/0274623 to Jacobs et al., which is hereby incorporated by reference in its entirety. Substitutions corresponding to these residues can be incorporated to the FN3 domains or the monospecific, bispecific, or multispecific FN3 domain containing binding molecules of the disclosure. 
     The binding molecule of the present disclosure is preferably an “isolated” binding molecule. “Isolated” when used to describe the binding molecule disclosed herein, means a binding molecule that has been identified, separated and/or recovered from a component of its production environment. Preferably, the isolated binding molecule is free of association with all other components from its production environment. Contaminant components of its production environment, such as that resulting from recombinant transfected cells, are materials that would typically interfere with diagnostic or therapeutic uses for the polypeptide, and may include enzymes, hormones, and other proteinaceous or non-proteinaceous solutes. In preferred embodiments, the binding molecule will be purified (1) to a degree sufficient to obtain at least 15 residues of N-terminal or internal amino acid sequence by use of a spinning cup sequenator, or (2) to homogeneity by SDS-PAGE under non-reducing or reducing conditions using Coomassie blue or, preferably, silver stain. Ordinarily, however, an isolated binding molecule will be prepared by at least one purification step. 
     As described supra, amino acid sequence modifications of the binding molecules described herein are contemplated. For example, it may be desirable to improve the binding affinity and/or other biological properties of the binding molecule. Amino acid sequence variants of the binding molecules are prepared by introducing appropriate nucleotide changes into the binding molecules nucleic acid, or by peptide synthesis. Such modifications include, for example, deletions from, and/or insertions into, and/or substitutions of, residues within the amino acid sequences of the binding molecules. Any combination of deletion, insertion, and substitution is made to arrive at the final construct, provided that the final construct possesses the desired characteristics, such as abolishment of protein A binding and FcγRI binding, or protease-resistance. 
     Exemplary modifications are for example conservative substitutions or functionally equivalent amino acid residue substitution and include those that will result in variants with similar characteristics to those of the parent binding molecules and fusion constructs described infra. Conservative substitutions are those that take place within a family of amino acids that are related in their side chains. Genetically encoded amino acids can be divided into four families: (1) acidic (aspartate, glutamate); (2) basic (lysine, arginine, histidine); (3) nonpolar (alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan); and (4) uncharged polar (glycine, asparagine, glutamine, cysteine, serine, threonine, tyrosine). Phenylalanine, tryptophan, and tyrosine are sometimes classified jointly as aromatic amino acids. Alternatively, the amino acid repertoire can be grouped as (1) acidic (aspartate, glutamate); (2) basic (lysine, arginine histidine), (3) aliphatic (glycine, alanine, valine, leucine, isoleucine, serine, threonine), with serine and threonine optionally grouped separately as aliphatic-hydroxyl; (4) aromatic (phenylalanine, tyrosine, tryptophan); (5) amide (asparagine, glutamine); and (6) sulfur-containing (cysteine and methionine) (Stryer (ed.), Biochemistry, 2nd ed, WH Freeman and Co., 1981, which is hereby incorporated by reference in its entirety). Non-conservative substitutions can be made to the binding molecules that involve substitutions of amino acid residues between different classes of amino acids to improve properties of the binding molecules and fusion constructs. Whether a change in the amino acid sequence of a polypeptide or fragment thereof results in a functional homolog can be readily determined by assessing the ability of the modified binding molecule to produce a response in a fashion similar to the unmodified binding molecule using assays described herein. 
     Another aspect of the present disclosure is directed to a fusion construct comprising a first portion comprising one or more binding molecules as described herein, and a second portion coupled to said first portion. The second portion of the fusion construct may comprise a second binding molecule, a pharmaceutically active moiety, a prodrug, a pharmaceutically-acceptable carrier, a diagnostic moiety, a cell penetrating enhancer moiety, a half-life extending modulating moiety, and any combination thereof. 
     In accordance with this aspect of the present disclosure, the first and second portions of the fusion construct are covalently coupled either directly or via a linker as described supra. The first and second portions may be directly fused and generated by standard cloning and expression techniques. Alternatively, well known chemical coupling methods may be used to attach the portions directly or via a peptide or other linker to recombinantly produce fusion constructs as described herein. 
     In one embodiment, the second portion of the fusion construct of the present disclosure comprises a half-life extending moiety. Exemplary half-life extending moieties include, without limitation, albumin, albumin variants (see e.g., U.S. Pat. No. 8,822,417 to Andersen et al., U.S. Pat. No. 8,314,156 to Desai et al., and U.S. Pat. No. 8,748,380 to Plumridge et al., which are hereby incorporated by reference in their entirety), albumin-binding proteins and/or domains, transferrin and fragments and analogues thereof (see e.g., U.S. Pat. No. 7,176,278 to Prior et al., which are hereby incorporated by reference in their entirety), Fc regions and variant Fc regions (see e.g., U.S. Pat. No. 8,546,543 to Lazar et al., U.S. Patent Publication No. 20150125444 to Tsui, and U.S. Pat. No. 8,722,615 to Seehra et al., which are hereby incorporated by reference in their entirety). 
     Other second portion half-life extending moieties of the fusion construct include, without limitation, polyethylene glycol (PEG) molecules, such as PEG5000 or PEG20,000, fatty acids and fatty acid esters of different chain lengths, for example laurate, myristate, stearate, arachidate, behenate, oleate, arachidonate, octanedioic acid, tetradecanedioic acid, octadecanedioic acid, docosanedioic acid, and the like, polylysine, octane, carbohydrates (dextran, cellulose, oligo- or polysaccharides) for desired properties. A pegyl moiety may for example be added to the bispecific or monospecific molecules of the disclosure by adding a cysteine residue to the C-terminus of the molecule and attaching a pegyl group to the cysteine using methods well known in the art. 
     In another embodiment, the second portion of the fusion construct comprises a pharmaceutically active moiety, such as, e.g., a cytokine, a toxin, a chemokine, an antibacterial peptide, an antibiotic, an enzyme, a peptide or protein with specific target binding characteristics, a fluorescent dye, a photosensitizer, a radionuclide, a contrast agent for medical imaging, a toxic compound, a pro-coagulant factor, an enzyme for pro-drug activation, an albumin binder, an albumin, an IgG binder or polyethylene glycol. 
     In another embodiment, the second portion of the fusion construct comprises a cell penetrating peptide (CPPs). CPPs translocate across the plasma membrane of eukaryotic cells by a seemingly energy-independent pathway and have been used successfully for intracellular delivery of macromolecules, including antibodies, peptides, proteins, and nucleic acids, with molecular weights several times greater than their own. Several commonly used CPPs, including polyarginines, transportant, protamine, maurocalcine, and M918 are known in the art (see Stewart et al., “Cell-Penetrating Peptides as Delivery Vehicles for Biology and Medicine,”  Organic Biomolecular Chem  6:2242-2255 (2008), which is hereby incorporated by reference in its entirety). In another embodiment, the second portion of the fusion construct comprises a cell penetrating enhancer moiety. Suitable cell penetrating enhancer moieties include, without limitation, oligo-arginyl derivatives (Bersani et al.,  Bioconjug. Chem.  23(7):1415-25 (2012), which is hereby incorporated by reference in its entirety), and corona-like (guanidyl)-oligosaccharidic derivatives (see WO2012/097876 To Caliceti et al., which is hereby incorporated by reference in its entirety). 
     In another embodiment, the second portion of the fusion construct comprises a diagnostic moiety. Suitable diagnostic moieties are those that facilitate the detection, quantitation, separation, and/or purification of the fusion construct. Suitable diagnostic moieties include, without limitation, purification tags (e.g., poly-histidine (His 6 ), glutathione-S-transferase (GST-), or maltose-binding protein (MBP-)), fluorescent tags (e.g., chelates (europium chelates), fluorescein and its derivatives, rhodamine and its derivatives, dansyl, Lissamine, phycoerythrin and Texas Red), an enzymatic tag, a radioisotope or radioactive label, a contrast agent suitable for imaging, or a photosensitize. 
     In another embodiment, the second portion of the fusion construct comprises a second binding molecule. In one aspect, the second binding molecule is an antibody or antibody binding domain thereof. As used herein, an “antibody” includes any protein or peptide containing molecule that comprises at least a portion of an immunoglobulin molecule, such as but not limited to, at least one, at least two, or at least three complementarity determining region (CDR) of a heavy or light chain, a heavy chain or light chain variable region, a heavy chain or light chain constant region, a framework region, or any portion thereof. Antibodies encompass full antibodies, digestion fragments, specified portions and variants thereof, including, without limitation, portions of antibodies that mimic the structure and/or function of an antibody or specified fragment or portion thereof, including, without limitation, single chain antibodies, single domain antibodies (i.e., antibody fragments comprising merely one variable domain, which might be VHH, VH or VL, that specifically bind an antigen or epitope independently of other V regions or domains). Functional fragments include antigen-binding fragments that bind to a particular target. For example, antibody fragments capable of binding to a particular target or portions thereof, include, but are not limited to, Fab (e.g., by papain digestion), Fab′ (e.g., by pepsin digestion and partial reduction) and F(ab′) 2  (e.g., by pepsin digestion), facb (e.g., by plasmin digestion), pFc′ (e.g., by pepsin or plasmin digestion), Fd (e.g., by pepsin digestion, partial reduction and reaggregation), Fv or scFv (e.g., by molecular biology techniques) fragments. 
     Such fragments can be produced by enzymatic cleavage, synthetic or recombinant techniques, as known in the art and/or as described herein. Antibodies can also be produced in a variety of truncated forms using antibody genes in which one or more stop codons have been introduced upstream of the natural stop site. For example, a combination gene encoding a F(ab′) 2  heavy chain portion can be designed to include DNA sequences encoding the CH 1  domain and/or hinge region of the heavy chain. The various portions of antibodies can be joined together chemically by conventional techniques, or can be prepared as a contiguous protein using genetic engineering techniques. 
     Furthermore, the term “antibody” encompasses monoclonal and polyclonal antibodies, as well as human, humanized, or chimeric antibodies, and derivatives or variants of the antibodies described herein which display the same specificity as the described antibodies. Examples of “antibody variants” include humanized variants of non-human antibodies, “affinity matured” antibodies (see e.g., Hawkins et al., “Selection of Phage Antibodies by Binding Affinity. Mimicking Affinity Maturation,”  J. Mol. Biol.  254:889-896 (1992) and Lowman et al., “Selecting High-Affinity Binding Proteins by Monovalent Phage Display,”  Biochemistry  30:10832-10837 (1991), each of which is hereby incorporated by reference in its entirety) and antibody mutants with altered effector function(s) (see, e.g., U.S. Pat. No. 5,648,260 to Winter et al., Kontermann and DUbel, A NTIBODY  E NGINEERING , Springer, 2 nd  ed. 2010, and Little, R ECOMBINANT  A NTIBODIES FOR  I MMUNOTHERAPY , Cambridge University Press, 2009, each of which is hereby incorporated by reference in its entirety). 
     In another embodiment, the second binding molecule comprises an antibody mimetic, i.e., an organic compound, often a peptide, polypeptide, or protein that binds specifically to an antigen, but is structurally unrelated to an antibody. Exemplary antibody mimetics include, without limitation, affibodies (scaffold based on the Z domain of Protein A), affilins (scaffold based on the structure of gamma crystallin or ubiquitin), affimers (scaffold based on the structure of cystatins), affitins (scaffold derived from the DNA binding protein Sac7d), alphabodies (scaffold based on a coiled coil structure), anticalins (scaffold derived from lipocalins), avimers (scaffold derived from A domains of various membrane receptors), DARPins (scaffold derived from ankyrin repeat motif), fynomers (scaffold derived from SH3 domain of Fyn), and Kunitz domain (scaffold derived from Kunitz domains of various protease inhibitors). 
     The second binding molecule may be a monospecific, bispecific, or multi-specific binding molecule, i.e., the second binding molecule has one, two, or multiple distinct binding sites for binding one or more distinct protein targets. The second binding molecule may be a monovalent, bivalent, or multi-valent, i.e., the second binding molecule has one, two, or multiple binding sites for a particular target molecule. For example, the second binding molecule may comprise an antibody that is monospecific, bispecific, or tri-specific, and the antibody may be monovalent, bivalent, or multi-valent. In one embodiment, the antibody is a mono-specific, bivalent antibody. 
     In one embodiment, the carboxy terminus of the second binding molecule is coupled to the amino terminus of the binding molecule of the present disclosure. In another embodiment the carboxy terminus of the second binding molecule is coupled to the carboxy terminus of the binding molecule of the present disclosure. When the second binding molecule comprises an antibody, one or more of the same or distinct binding molecules may be coupled to the light chain and/or the heavy chain of the antibody, or binding fragments thereof. In one embodiment, one or more of the same or distinct binding molecules are coupled to one or more of the heavy chains of an antibody. In another embodiment, one or more of the same or distinct binding molecules are coupled to one or more of the light chains of an antibody. In another embodiment, one or more distinct binding molecules are coupled to one or more of the light chains and the heavy chains of an antibody. 
     In one aspect, the second binding molecule is resistant to proteolytic degradation by a staphylococcal protease that cleaves wild-type IgG1 (such as the staphylococcal protease,  Staphylococcus aureus  V8 protease, that cleaves wild-type IgG1 between or at residues 222-237 (EU numbering) within SEQ ID NO: 60) (see U.S. Pat. No. 8,871,204 to Strohl et al., which is hereby incorporated by reference in its entirety). 
     In one aspect, the second binding molecule is not capable of specific binding to human FcγRI, is not capable of specific binding to Protein A, and is not capable of specific binding to Sbi. In one aspect, the second binding molecule is capable of specific binding to FcRn. 
     In one embodiment, the second binding molecule of the fusion construct has binding specificity for a staphylococcal protein. In one embodiment, the second binding molecule has binding specificity for a staphylococcal virulence factor. As used herein a “virulence factor” refers to a molecule expressed by staphylococcal protein that enables the bacteria to achieve colonization of a niche in the host (including adhesion to cells), immunoevasion (i.e., evasion of the host&#39;s immune response), immunosuppression (i.e., inhibition of the host&#39;s immune response), entry into and exit out of cells (if the pathogen is an intracellular one), and/or obtain nutrition from the host. The virulence factor may be encoded on mobile genetic elements, such as bacteriophages, and can easily be spread through horizontal gene transfer. Non-limiting examples of  Staphylococcus aureus  virulence factors include hyaluronidase, protease, coagulase, lipases, deoxyribonucleases, enterotoxins and other toxins. For purposes of this disclosure, staphylococcal surface proteins, such as SDR-containing proteins, e.g., ClfA, ClfB, SdrC, SdrD, SdrE, SdrF, SdrG and SdrH, are also considered virulence factors. 
     In one embodiment, the second binding molecule of the fusion construct of the present disclosure is capable of binding to a glycosylated staphylococcal surface protein. Exemplary second binding molecules that bind a glycosylated staphylococcal surface protein include the antibodies and antibody binding domain fragments disclosed in U.S. Pat. Nos. 8,460,666 and 8,211,431 to Throsby et al., which is hereby incorporated by reference in its entirety. In one embodiment, the antibody or antibody binding domain that binds a glycosylated staphylococcal surface protein has an immunoglobulin heavy chain comprising an amino acid sequence selected from SEQ ID NOs: 60, 62, 64 or 66. In another embodiment, the antibody or antibody binding domain that binds a glycosylated staphylococcal surface protein has an immunoglobulin light chain comprising an amino acid sequence of SEQ ID NOs: 61, 63, 65 or 67. Alternatively, the second binding molecule comprises an antibody having (a) a heavy chain having the amino acid sequence of SEQ ID NOs:60, 62, 64 or 66; and (b) a light chain having the amino acid sequence of SEQ ID NOs:61, 63, 65 or 67. In another embodiment, the second binding molecule comprises an antibody having (1) a heavy chain having the amino acid sequence of SEQ ID NO:60, and a light chain having the amino acid sequence of SEQ ID NO:61; (2) a heavy chain having the amino acid sequence of SEQ ID NO:62, and a light chain having the amino acid sequence of SEQ ID NO:63; (3) a heavy chain having the amino acid sequence of SEQ ID NO:64, and a light chain having the amino acid sequence of SEQ ID NO:65; (4) a heavy chain having the amino acid sequence of SEQ ID NO:66, and a light chain having the amino acid sequence of SEQ ID NO:67; (5) a heavy chain having the amino acid sequence of SEQ ID NO:68, and a light chain having the amino acid sequence of SEQ ID NO:69; (6) a heavy chain having the amino acid sequence of SEQ ID NO:70, and a light chain having the amino acid sequence of SEQ ID NO:71; (7) a heavy chain having the amino acid sequence of SEQ ID NO:72, and a light chain having the amino acid sequence of SEQ ID NO:73; (8) a heavy chain having the amino acid sequence of SEQ ID NO:74, and a light chain having the amino acid sequence of SEQ ID NO:75; (9) a heavy chain having the amino acid sequence of SEQ ID NO:76, and a light chain having the amino acid sequence of SEQ ID NO:77; or (10) a heavy chain having the amino acid sequence of SEQ ID NO:78, and a light chain having the amino acid sequence of SEQ ID NO:79. 
     In one embodiment, the fusion construct of the present disclosure comprises a binding molecule having a LukE binding region coupled to an immunoglobulin heavy chain, where the heavy chain comprises a variable region that binds to a glycosylated staphylococcal surface protein. Exemplary fusion constructs according to this aspect of the present disclosure comprise an amino acid sequence of any one of SEQ ID NOs: 848-851, 900, or 903. In one embodiment, these exemplary fusion constructs further comprise an immunoglobulin light chain variable region. Suitable light chains include, without limitation, light chains having an amino acid sequence of any one of SEQ ID NO: 61, 63, 65 or 67. 
     In another embodiment, the fusion construct of the present disclosure comprises a binding molecule having a LukE binding region coupled to an immunoglobulin light chain, where the light chain comprises a variable region that binds to a glycosylated staphylococcal surface protein. An exemplary fusion construct according to this aspect comprises an amino acid sequence of SEQ ID NO: 980. In one embodiment, these exemplary fusion constructs further comprise an immunoglobulin heavy chain variable region or heavy chain. Suitable heavy chains include, without limitation, heavy chains having an amino acid sequence of any one of SEQ ID NOs: 60, 62, 64 or 66. 
     In one embodiment, the fusion construct of the present disclosure comprises a binding molecule having a LukAB binding region coupled to an immunoglobulin heavy chain, where the heavy chain comprises a variable region that binds to a glycosylated staphylococcal surface protein. Exemplary fusion constructs according to this aspect of the present disclosure comprise an amino acid sequence of any one of SEQ ID NOs: 70 and 72. In one embodiment, these exemplary fusion constructs further comprise an immunoglobulin light chain. Suitable light chains include, without limitation, light chains having an amino acid sequence of any one of SEQ ID NO: 61, 63, 65 or 67. 
     In another embodiment, the fusion construct of the present disclosure comprises a binding molecule having a LukAB binding region coupled to an immunoglobulin light chain, where the light chain comprises a variable region that binds to a glycosylated staphylococcal surface protein. Exemplary fusion constructs according to this aspect of the present disclosure comprise an amino acid sequence of SEQ ID NO: 979. In one embodiment, these exemplary fusion constructs further comprise an immunoglobulin heavy chain variable region or heavy chain. Suitable heavy chains include, without limitation, heavy chains having an amino acid sequence of any one of SEQ ID NO: 60, 62, 64 or 66. 
     In another embodiment, the fusion construct of the present disclosure comprises a binding molecule having a LukE binding region and a LukAB binding region coupled to an immunoglobulin heavy chain, where the heavy chain comprises a variable region that binds to a glycosylated staphylococcal surface protein. Exemplary fusion constructs according to this aspect of the disclosure comprise an amino acid sequence of any one of SEQ ID NOs: 852-859, 887, 888, 893, 894, 906, 920, 931-956, 961, 976, and 984-988. In one embodiment, these exemplary fusion constructs further comprise an immunoglobulin light chain variable region or light chain comprising a glycosylated staphylococcal surface protein binding domain. Suitable immunoglobulin light chains include, without limitation, light chains having an amino acid sequence of any one of SEQ ID NO: 61, 63, 65 or 67. 
     Another aspect of the present disclosure is directed to nucleic acid molecules encoding the binding molecules and fusion constructs described herein. The nucleic acid molecules of the present disclosure include isolated polynucleotides, portions of expression vectors or portions of linear DNA sequences, including linear DNA sequences used for in vitro transcription/translation, vectors compatible with prokaryotic, eukaryotic or filamentous phage expression, secretion and/or display of the compositions or directed mutagens thereof. 
     In one embodiment isolated polynucleotides of the present disclosure include those encoding the binding molecules described supra. Exemplary isolated polynucleotide molecules include those encoding a FN3 domain that comprises a LukE binding region having any one of the amino acid sequences of SEQ ID NOs: 25-59, 113,116-136, 155, 363, 364, 366-369, 375, 376, 388, 586, and 739-839. In another embodiment, exemplary polynucleotides include those encoding a FN3 domain that comprises a LukAB binding region having any one of the amino acid sequences of SEQ ID NOs: 14, 15, 16, 17, 145, 156, 158, 167, 214, 226, 247, 282, 286, 316, 370, 386, 388, 392, 446, 454, 462, 530, 540, 568, 574, 584, 587-666 and 672-738. In another embodiment, exemplary polynucleotides include those encoding a FN3 domain that comprises an Hla binding region having any one of the amino acid sequences of SEQ ID Nos: 1097, 1099, 1112, 1142, and 1100. 
     In other embodiment, exemplary polynucleotides include isolated polynucleotides encoding the antibody-binding molecule fusion constructs described herein. For example, exemplary isolated polynucleotides include those encoding a fusion construct comprising a binding molecule having a LukE binding domain coupled to an immunoglobulin heavy chain comprising a glycosylated staphylococcal surface protein binding domain (e.g., polynucleotides encoding amino acid sequences of SEQ ID NOs: 848-851, 900 or 903), and a LukE binding domain coupled to an immunoglobulin light chain comprising a glycosylated staphylococcal surface protein binding domain (e.g., a polynucleotide encoding an amino acid sequence of SEQ ID NO: 980). Exemplary isolated polynucleotides also include those encoding a fusion construct comprising a binding molecule having a LukAB binding domain coupled to an immunoglobulin heavy chain comprising a glycosylated staphylococcal surface protein binding domain (e.g., polynucleotides encoding amino acid sequences of SEQ ID NOs: 70 and 72), and a LukAB binding domain coupled to an immunoglobulin light chain comprising a glycosylated staphylococcal surface protein binding domain (e.g., a polynucleotide encoding an amino acid sequence of SEQ ID NO: 979). Exemplary isolated polynucleotides also include those encoding a fusion construct comprising a binding molecule having LukE and LukAB binding domains coupled to a immunoglobulin heavy chain comprising a glycosylated staphylococcal surface protein binding region (e.g., polynucleotides encoding amino acid sequences of SEQ ID NOs: 852-859, 887, 888, 893, 894, 906, 920, 931-956, 961, 976, and 984-988). 
     The polynucleotides of the disclosure may be produced by chemical synthesis such as solid phase polynucleotide synthesis on an automated polynucleotide synthesizer and assembled into complete single or double stranded molecules. Alternatively, the polynucleotides of the disclosure may be produced by other techniques such a PCR followed by routine cloning. Techniques for producing or obtaining polynucleotides of a given known sequence are well known in the art. 
     The polynucleotides described herein may comprise at least one non-coding sequence, such as a promoter or enhancer sequence, intron, polyadenylation signal, a cis sequence facilitating RepA binding, and the like. The polynucleotide sequences may also comprise additional sequences encoding additional amino acids that encode for example a marker or a tag sequence such as a histidine tag or an HA tag to facilitate purification or detection of the protein, a signal sequence, a fusion protein partner such as RepA, Fc or bacteriophage coat protein such as pIX or pIII. 
     Another embodiment of the disclosure is a vector comprising at least one polynucleotides as described herein. Such vectors may be plasmid vectors, viral vectors, vectors for baculovirus expression, transposon based vectors or any other vector suitable for introduction of the polynucleotides of the invention into a given organism or genetic background by any means. Such vectors may be expression vectors comprising nucleic acid sequence elements that can control, regulate, cause or permit expression of a polypeptide encoded by such a vector. Such elements may comprise transcriptional enhancer binding sites, RNA polymerase initiation sites, ribosome binding sites, and other sites that facilitate the expression of encoded polypeptides in a given expression system. Such expression systems may be cell-based, or cell-free systems well known in the art. 
     Another embodiment of the present disclosure is a host cell comprising the above described vectors. The binding molecules and/or fusion constructs disclosed herein can be optionally produced by a cell line, a mixed cell line, an immortalized cell or clonal population of immortalized cells, as well known in the art (see e.g., Ausubel et al., ed., Current Protocols in Molecular Biology, John Wiley &amp; Sons, Inc., NY, N.Y. (1987-2001); Sambrook et al., Molecular Cloning: A Laboratory Manual, 2 nd  Edition, Cold Spring Harbor, N.Y. (1989); Harlow and Lane, Antibodies, a Laboratory Manual, Cold Spring Harbor, N.Y. (1989); Colligan et al., eds., Current Protocols in Immunology, John Wiley &amp; Sons, Inc., NY (1994-2001); Colligan et al., Current Protocols in Protein Science, John Wiley &amp; Sons, NY, N.Y., (1997-2001), which are hereby incorporated by reference in their entirety). 
     The host cell chosen for expression may be of mammalian origin or may be selected from COS-1, COS-7, HEK293, BHK21, CHO, BSC-1, He G2, SP2/0, HeLa, myeloma, lymphoma, yeast, insect or plant cells, or any derivative, immortalized or transformed cell thereof. Alternatively, the host cell may be selected from a species or organism incapable of glycosylating polypeptides, e.g. a prokaryotic cell or organism, such as BL21, BL21(DE3), BL21-GOLD(DE3), XL1-Blue, JM109, HMS174, HMS174(DE3), and any of the natural or engineered  E. coli  spp,  Klebsiellaspp ., or  Pseudomonas  spp strains. 
     Another aspect of the disclosure is directed to a method of producing and isolating the binding molecules and fusion constructs as described herein. This method involves culturing the isolated host cell of the disclosure under conditions such that the binding molecules or fusion constructs are expressed, and purifying the expressed binding molecules or fusion constructs from the host cell culture. 
     The binding molecules and fusion constructs described herein can be purified from recombinant cell cultures by well-known methods, for example by protein A purification, ammonium sulfate or ethanol precipitation, acid extraction, anion or cation exchange chromatography, phosphocellulose chromatography, hydrophobic interaction chromatography, affinity chromatography, hydroxylapatite chromatography and lectin chromatography, or high performance liquid chromatography (HPLC). 
     Purified or isolated binding molecules and fusion constructs as described herein may be linked to one of a variety of non-proteinaceous polymers, e.g., polyethylene glycol, polypropylene glycol, polyoxyalkylenes, or copolymers of polyethylene glycol and polypropylene glycol. The binding molecules and/or fusion constructs may also be entrapped in microcapsules prepared, for example, by coacervation techniques or by interfacial polymerization (for example, hydroxymethylcellulose or gelatine-microcapsules and poly (methylmethacylate) microcapsules, respectively), in colloidal drug delivery systems (for example, liposomes, albumin microspheres, microemulsions, nanoparticles and nanocapsules), or in macroemulsions. Such techniques are disclosed in R EMINGTON&#39;S  P HARMACEUTICAL  S CIENCES , 16th edition, Oslo, A., Ed., (1980), which is hereby incorporated by reference in its entirety. 
     For therapeutic use, the binding molecules and fusion constructs as described herein may be prepared as pharmaceutical compositions containing an effective amount of the binding molecules as an active ingredient in a pharmaceutically acceptable carrier. The term “carrier” refers to a diluent, adjuvant, excipient, or vehicle with which the active compound is administered. Such vehicles can be liquids, such as water and oils, including those of petroleum, animal, vegetable or synthetic origin, such as peanut oil, soybean oil, mineral oil, sesame oil and the like. For example, 0.4% saline and 0.3% glycine can be used. These solutions are sterile and generally free of particulate matter. They may be sterilized by conventional, well-known sterilization techniques (e.g., filtration). The compositions may contain pharmaceutically acceptable auxiliary substances as required to approximate physiological conditions such as pH adjusting and buffering agents, stabilizing, thickening, lubricating and coloring agents, etc. The concentration of binding molecule or fusion construct as described herein in such pharmaceutical formulation can vary widely, i.e., from less than about 0.5%, usually at or at least about 1% to as much as 15 or 20% by weight and will be selected primarily based on required dose, fluid volumes, viscosities, etc., according to the particular mode of administration selected. Suitable vehicles and formulations, inclusive of other human proteins, e.g., human serum albumin, are described, for example, in e.g. R EMINGTON: THE  S CIENCE AND  P RACTICE OF  P HARMACY , 21 st  Edition, Troy, D. B. ed., Lipincott Williams and Wilkins, 2006, Part 5, Pharmaceutical Manufacturing pp 691-1092, see especially pp. 958-989, which is hereby incorporated by reference in its entirety. 
     The binding molecules and fusion constructs described herein can be used in non-isolated or isolated form. Furthermore, the binding molecules and fusion constructs hereof can be used alone or in a mixture comprising at least one other binding molecule or fusion construct hereof. In other words, the binding molecules and fusion constructs can be used in combination, e.g., as a pharmaceutical composition comprising two or more binding molecules hereof, two or more fusion constructs, a binding molecule and fusion construct, and variants or fragments thereof. For example, binding molecules and/or fusion constructs having different, but complementary activities can be combined in a single therapy to achieve a desired therapeutic effect, but alternatively, binding molecules and fusion constructs having identical activities can also be combined in a single therapy to achieve a desired prophylactic, therapeutic or diagnostic effect. Optionally, the mixture further comprises at least one other therapeutic agent. In one aspect, the other therapeutic agent may be an anti-infective agent, an antibiotic agent, and/or an antimicrobial agent that is useful in the prophylaxis and/or treatment of a staphylococcal infection. In another aspect, the other therapeutic agent may be any agent that is useful in the prophylaxis and/or treatment of a condition associated with a staphylococcal infection. 
     The binding molecules, fusion constructs, or pharmaceutical compositions containing the same can be used for the treatment, prevention or amelioration of a staphylococcal infection. The staphylococcal infection may be caused by any  Staphylococcus  spp. In one aspect, the staphylococcal infection is caused by  Staphylococcus aureus , including methicillin-resistant  S. aureus  (MRSA) and methicillin-sensitive  S. aureus  (MSSA). Accordingly, the present disclosure provides a method for the treatment, prevention or amelioration of a staphylococcal infection that involves administering to a subject in need thereof a binding molecule, fusion construct, or compositions containing the same as described herein. 
     In accordance with this aspect, the target “subject” encompasses any animal, for example, a mammal, such as a human. In the context of administering a composition of the disclosure for purposes of preventing a staphylococcal infection in a subject, the target subject encompasses any subject that is at risk of becoming infected with  Staphylococcus  or developing a staphylococcal infection. Susceptible subjects include infants and juveniles, as well as immunocompromised juvenile, adults, and elderly adults. However, any infant, juvenile, adult, or elderly adult or immunocompromised individual at risk for developing a staphylococcal infection can be treated in accordance with the methods described herein. In the context of administering a composition of the disclosure for purposes of treating a staphylococcal infection in a subject, the target subject encompasses any subject infected with  Staphylococcus . Particularly suitable subjects include those at risk of infection, susceptible to infection, or those infected with methicillin-resistant  S. aureus  (MRSA) or methicillin sensitive  S. aureus  (MSSA). Other suitable subjects include those subjects which may have or are at risk for developing a condition resulting from a  Staphylococcus  infection, i.e., a staphylococcal associated condition, such as, for example, skin wounds and infections, tissue abscesses, folliculitis, osteomyelitis, pneumonia, scalded skin syndrome, septicemia, septic arthritis, myocarditis, endocarditis, and toxic shock syndrome. 
     In one embodiment, the binding molecules, fusion constructs, or pharmaceutical compositions containing the same are administered prophylactically to prevent, delay, or inhibit the development of staphylococcal infection in a subject at risk of developing a staphylococcal infection or associated condition. In one aspect, prophylactic administration of one or more binding molecules described herein is effective to fully prevent  S. aureus  infection in an individual. In other embodiments, prophylactic administration is effective to prevent the full extent of infection that would otherwise develop in the absence of such administration, i.e., substantially prevent, inhibit, or minimize staphylococcal infection in an individual. 
     In another embodiment, the binding molecules, fusion constructs, or pharmaceutical compositions as described herein are administered therapeutically to an individual having a staphylococcal infection to inhibit the progression and further development of the infection, i.e., to inhibit and/or prevent the spread of the infection to other cells in an individual, decrease infection, and to treat or alleviate one or more symptoms of infection. 
     Therapeutically effective amounts of the binding molecules and fusion constructs described herein are determined in accordance with standard procedures, which take numerous factors into account, including, for example, the concentrations of the binding molecules or fusion constructs in a pharmaceutical composition, the mode and frequency of administration, the severity of the  Staphylococcus  infection to be treated (or prevented), and subject details, such as age, weight and overall health and immune condition. General guidance can be found, for example, in the publications of the International Conference on Harmonization and in REMINGTON&#39;S PHARMACEUTICAL SCIENCES (Mack Publishing Company 1990), which is hereby incorporated by reference in its entirety. A clinician may administer a composition comprising the binding molecules or fusion constructs described herein in a single dose or in accordance with a multi-dosing protocol until a dosage is reached that provides the desired or required prophylactic or therapeutic effect. The progress of this therapy can be easily monitored by conventional assays. In prophylactic applications, a relatively low dosage is administered at relatively infrequent intervals over a long period of time. In therapeutic applications, a relatively high dosage at relatively short intervals (e.g., as little as 15 minutes, 30 minutes, 60 minutes, 90 minutes or even 2 or 3 hours) is sometimes required until progression of the disease is reduced or terminated, and preferably until the subject shows partial or complete amelioration of symptoms of disease. 
     The therapeutically effective amount, i.e., the dosage sufficient for a subject having a staphylococcal infection that is sufficient to slow or prevent the spread or severity of staphylococcal infection, and/or the dosage sufficient to prevent, alleviate (either partially or completely) a staphylococcal infection associated condition. Such therapeutically effective amounts vary by individual, but may range from 0.1 to 10 mg/kg body weight, for example 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 mg/kg, but may even higher, for example 15, 20, 30, 40, 50, 60, 70, 80, 90 or 100 mg/kg. A fixed unit dose may also be given, for example, 50, 100, 200, 500 or 1000 mg, or the dose may be based on the patient&#39;s surface area, e.g., 400, 300, 250, 200, or 100 mg/m 2 . Usually between 1 and 8 doses, (e.g., 1, 2, 3, 4, 5, 6, 7 or 8) may be administered to treat infection, but 10, 12, 20 or more doses may be given depending on the severity of infection. Administration of binding molecules or fusion constructs of the present disclosure may be repeated after one day, two days, three days, four days, five days, six days, one week, two weeks, three weeks, one month, five weeks, six weeks, seven weeks, two months, three months, four months, five months, six months or longer. Repeated courses of treatment are also possible, as is chronic administration. The repeated administration may be at the same dose or at a different dose. 
     The therapeutic compositions of the present disclosure can be administered alone or as part of a combination therapy in conjunction with one or more other active agents, depending upon the nature of the  Staphylococcus  infection that is being treated. Such additional active agents include anti-infective agents, antibiotic agents, and antimicrobial agents that are readily known in the art. 
     The mode of administration of the binding molecules, fusion constructs, and pharmaceutical compositions described herein may be any suitable route that delivers the binding molecule(s) or fusion construct(s) to the host, such as parenteral administration, e.g., intradermal, intramuscular, intraperitoneal, intravenous or subcutaneous, pulmonary; transmucosal (oral, intranasal, intravaginal, rectal); using a formulation in a tablet, capsule, solution, powder, gel, particle; and contained in a syringe, an implanted device, osmotic pump, cartridge, micropump; or other means appreciated by the skilled artisan, as well known in the art. Site specific administration may be achieved by, for example, intrarticular, intrabronchial, intraabdominal, intracapsular, intracartilaginous, intracavitary, intracelial, intracerebellar, intracerebroventricular, intracolic, intracervical, intragastric, intrahepatic, intracardial, intraosteal, intrapelvic, intrapericardiac, intraperitoneal, intrapleural, intraprostatic, intrapulmonary, intrarectal, intrarenal, intraretinal, intraspinal, intrasynovial, intrathoracic, intrauterine, intravascular, intravesical, intralesional, vaginal, rectal, buccal, sublingual, intranasal, or transdermal delivery. 
     The binding molecules and fusion constructs provided herein can also be used in methods for diagnosing a staphylococcal infection in a subject. In one aspect, the method for diagnosing a staphylococcal infection involves contacting a binding molecule or fusion construct as described herein with a sample from the subject to be diagnosed, and detecting at least the presence or the absence of one or more staphylococcal leukotoxins in the sample. In another aspect, the method for diagnosing a staphylococcal infection involves contacting a binding molecule or fusion construct as described herein with a sample from the subject to be diagnosed, and detecting the presence or the absence of one or more staphylococcal leukotoxins in the sample and the presence or absence of one or more other staphylococcal proteins, such as, e.g., a glycosylated staphylococcal surface protein. A staphylococcal infection is diagnosed in the subject based on this detection. In other words, the detection of the one or more staphylococcal leukotoxins alone or in combination with another staphylococcal protein indicates a positive diagnosis of a staphylococcal infection. 
     In accordance with this aspect, the sample from the subject may comprise a blood, tissue, cell, serum, or any other biological sample. 
     Another aspect relates to a method for the detection of a staphylococcal infection in a sample. This method involves contacting the binding molecule or fusion construct as described herein with a sample, and detecting the presence or the absence of a at least one or more staphylococcal leukotoxins. Optionally, the presence or absence of one or more staphylococcal leukotoxins and one or more additional staphylococcal proteins, e.g., glycosylated staphylococcal surface proteins, can be detected using one or more of the fusion constructs described herein. Detection of the one or more staphylococcal leukotoxins alone or in combination with another staphylococcal protein indicates the presence of  Staphylococcus  in the sample. In accordance with this aspect, the sample may be any biological sample obtained from the environment, an animal, or a human. 
     Methods described herein involving the detection of a staphylococcal leukotoxin alone or in combination with another staphylococcal protein in a sample from a subject or elsewhere involve the use of a detectably labeled binding molecule or fusion construct. Accordingly, in one aspect the binding molecule or fusion construct as described herein may be coupled to a detectable label. Suitable detectable labels are well known in the art and include detectable tags (e.g., a poly-histidine (His 6 ) tag, a glutathione-S-transferase (GST-) tag, or a maltose-binding protein (MBP-) tag); radioactive labels (e.g., carbon ( 14 C) or phosphorous ( 32 P)); fluorescent labels (e.g., fluorescein and derivatives thereof, fluorescein isothiocyanate, rhodamine and derivatives thereof, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin); luminescent labels (e.g., luminol); bioluminescent labels (e.g., luciferase, luciferin, and aequorin); or enzymatic labels (e.g., luciferin, 2,3-dihydrophthalazinediones, malate dehydrogenase, urease, peroxidases (e.g., horseradish peroxidase), alkaline phosphatase, β-galactosidase, glucoamylase, lysozyme, saccharide oxidases (e.g., glucose oxidase, galactose oxidase, and glucose-6-phosphate dehydrogenase), heterocyclic oxidases (e.g., uricase and xanthine oxidase), lactoperoxidase, microperoxidase). Alternatively, the binding molecule can be bound by a detectable label, for example, bound by a secondary antibody that contains a detectable label. 
     Detection assays for detecting the labeled binding molecule or fusion construct bound to a staphylococcal leukotoxin and/or another staphylococcal protein in a sample are well known in the art and include, for example, immunoprecipitation, enzyme-linked immunosorbent assay (ELISA), radioimmunoassay (RIA), or fluorescent activated cell sorting (FACS). 
     Furthermore, the binding molecules and fusion constructs of the present disclosure can be used for the prevention of a staphylococcal infection. This method involves contacting the binding molecule or fusion construct as described herein with a sample from a subject, and detecting a staphylococcal leukotoxin and/or another staphylococcal protein, e.g., a glycosylated staphylococcal surface protein as a result of the contacting. If a staphylococcal leukotoxin and/or another staphylococcal protein is detected in the subject sample, then an agent suitable for preventing staphylococcal infection is administered to the subject. Exemplary prophylactic agents include, but are not limited to, the binding molecules described herein, one or more antibiotics (e.g., mupirocin, nafcillin, cefazolin, dicloxacillin, clindamycin, vancomycin, linezolid, rifampin, sulfamethoxazole-trimethoprim), and/or other anti-infective agents that are effective against staphylococcal infection. 
     Another aspect of the present disclosure is directed to Leukocidin B (LukB) and Leukocidin A (LukA) polypeptides comprising stem domain mutations and/or deletions. The stem domains of the bi-component leukocidins are structural domains involved in the formation of the active oligomeric, pore forms of the toxins that pierce the host cell membrane and cause cell death via osmotic lysis. As demonstrated in the Examples herein, the stem domain variants of LukA and LukB retain the neutralizing epitope recognized by the LukAB binding molecule (Luk17) described herein. Accordingly, since the stem domain variants do not exhibit cytolytic activity, yet present a neutralizing epitope, they make ideal components of a  S. aureus  vaccine composition. 
     In one embodiment, the recombinant LukB polypeptide stem domain variant comprises an amino acid sequence corresponding to amino acid residues 1-109 of SEQ ID NO: 1026 coupled to amino acid residues 152-305 of SEQ ID NO: 1026. The LukB polypeptide does not comprise one or more amino acid residues corresponding to amino acid residues 110-151 of SEQ ID NO: 1026. In other words, one or more amino acid residues corresponding to amino acid residues 110-151 of SEQ ID NO: 1026 is deleted or mutated, thereby rendering the stem domain of the LukB polypeptide inactive or non-functional. When two or more amino acid residues are deleted or mutated, the two or more amino acid residues may be contiguous or non-contiguous. For example, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, or 42 contiguous or non-contiguous amino acid residues within the stretch of amino acid residues corresponding to 110-151 of SEQ ID NO: 1026 are deleted or mutated in the LukB polypeptide as described herein. In one embodiment, the LukB polypeptide comprises a deletion of amino acid residues corresponding to amino acid residues 122-126 of SEQ ID NO: 1026. In another embodiment, the LukB polypeptide comprises a deletion of amino acid residues corresponding to amino acid residues 130-134 of SEQ ID NO: 1026. In another embodiment, the LukB polypeptide comprises a deletion of amino acid residues corresponding to amino acid residues 108-150 of SEQ ID NO: 1026. In another embodiment, the LukB polypeptide comprises a deletion of amino acid residues corresponding to amino acid residues 110-150 of SEQ ID NO: 1026. In another embodiment, the LukB polypeptide comprises a deletion of amino acid residues corresponding to amino acid residues 110-151 of SEQ ID NO: 1026. The remaining portions of the LukB polypeptide, e.g., amino acid residues corresponding to and comprising residues 1-109 of SEQ ID NO: 1026 and 152-305 of SEQ ID NO: 1026 can be coupled directly or via a short linker. Suitable linkers include, without limitation, glycine-rich (e.g. G 3-5 ) or glycine/serine-rich (e.g. GSG, GSGS, (SGG) 2 , GS N G) linker sequences. 
     Exemplary LukB polypeptides in accordance with this aspect of the disclosure include, without limitation, LukB polypeptides comprising an amino acid sequence of SEQ ID NO: 1029, SEQ ID NO: 1030, SEQ ID NO: 1031, SEQ ID NO: 1032, SEQ ID NO: 1150, or SEQ ID NO: 1151. 
     The recombinant Leukocidin A (LukA) polypeptide stem domain variant comprises an amino acid sequence corresponding to amino acid residues 1-134 of SEQ ID NO: 1018 coupled to amino acid residues 175-324 of SEQ ID NO: 1018. The LukA polypeptide does not comprise one or more amino acid residues corresponding to amino acid residues 135-174 of SEQ ID NO: 1018. In other words, one or more amino acid residues corresponding to amino acid residues 135-174 of SEQ ID NO: 1018 is deleted or mutated, thereby rendering the stem domain of the LukA polypeptide inactive or non-functional. When two or more amino acid residues are mutated or deleted, the two or more amino acid residues may be contiguous or non-contiguous. For example, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, or 40 contiguous or non-contiguous amino acid residues within the stretch of amino acid residues corresponding to 135-174 of SEQ ID NO: 1018 are deleted or mutated in the LukA polypeptide as described herein. In one embodiment, the LukA polypeptide comprises a deletion of amino acid residues corresponding to amino acid residues 144-149 of SEQ ID NO: 1018. In another embodiment, the LukA polypeptide comprises a deletion of amino acid residues corresponding to amino acid residues 135-174 of SEQ ID NO: 1018. The remaining portions of the LukA polypeptide, i.e., amino acid residues corresponding to residues 1-134 or SEQ ID NO: 1018 and 175-324 of SEQ ID NO: 1018 can be coupled directly or via a suitable linker. Suitable linkers include, without limitation, glycine-rich (e.g. G 3-5 ) or glycine/serine-rich (e.g. GSG, GSGS, (SGG) 2 , GS N G) linker sequences. 
     The recombinant LukA polypeptide as described herein may further comprise a glutamic acid to alanine substitution at the amino acid residue corresponding to amino acid residue 323 of SEQ ID NO: 1018 (DuMont et al., “Identification of a Crucial Residue Required for  Staphylococcus aureus  LukAB Cytotoxicity and Receptor Recognition,”  Infect Immun.  82(3):1268-76 (2014), which is hereby incorporated by reference in its entirety). 
     Exemplary LukA polypeptides in accordance with this aspect of the disclosure include, without limitation, LukA polypeptides comprising an amino acid sequence of SEQ ID NO: 1022, SEQ ID NO: 1023, SEQ ID NO: 1024, SEQ ID NO: 1025, or SEQ ID NO: 1149. 
     Another aspect of the present disclosure is directed to a vaccine composition comprising the LukB and LukA stem domain variants as described supra. In other words, the vaccine composition comprises a recombinant Leukocidin B (LukB) polypeptide comprising an amino acid sequence corresponding to amino acid residues 1-109 of SEQ ID NO: 1026 coupled to amino acid residues 152-305 of SEQ ID NO: 1026, wherein said LukB polypeptide does not comprise one or more amino acid residues corresponding to amino acid residues 110-151 of SEQ ID NO: 1026. The vaccine composition further comprises a recombinant Leukocidin A (LukA) polypeptide comprising an amino acid sequence corresponding to amino acid residues 1-134 of SEQ ID NO: 1018 coupled to amino acid residues 177-324 of SEQ ID NO: 1018, wherein said LukA polypeptide does not comprise one or more amino acid residues corresponding to amino acid residues 135-174 of SEQ ID NO: 1018. Exemplary LukB and LukA stem domain variants are described supra. 
     The vaccine composition may further comprise one or more adjuvants. Suitable adjuvants are known in the art and include, without limitation, flagellin, Freund&#39;s complete or incomplete adjuvant, aluminum hydroxide, lysolecithin, pluronic polyols, polyanions, peptides, oil emulsion, dinitrophenol, iscomatrix, and liposome polycation DNA particles. 
     The vaccine composition as described herein may be prepared by formulating the recombinantly produced LukA and LukB stem domain variants with a pharmaceutically acceptable carrier and optionally a pharmaceutically acceptable excipient. As used herein, the terms “pharmaceutically acceptable carrier” and “pharmaceutically acceptable excipient” (e.g., additives such as diluents, immunostimulants, adjuvants, antioxidants, preservatives and solubilizing agents) are nontoxic to the cell or mammal being exposed thereto at the dosages and concentrations employed. Examples of pharmaceutically acceptable carriers include water, e.g., buffered with phosphate, citrate and another organic acid. Representative examples of pharmaceutically acceptable excipients that may be useful include antioxidants such as ascorbic acid; low molecular weight (less than about 10 residues) polypeptides; proteins, such as serum albumin, gelatin, or immunoglobulins; adjuvants; hydrophilic polymers such as polyvinylpyrrolidone; amino acids such as glycine, glutamine, asparagine, arginine or lysine; monosaccharides, disaccharides, and other carbohydrates including glucose, mannose, or dextrins; chelating agents such as EDTA; sugar alcohols such as mannitol or sorbitol; salt forming counterions such as sodium; and/or nonionic surfactants such as TWEEN®, polyethylene glycol (PEG), and PLURONICS®. 
     Another aspect of the present disclosure relates to a method of immunizing a subject against a  Staphylococcus aureus  infection. This method involves administering the vaccine composition comprising the LukA and LukB stem domain variants, in an amount effective to immunize against  S. aureus  infection in the subject. A suitable subject for treatment in accordance with this aspect of the present invention is a subject at risk of developing a  S. aureus  infection. 
     In accordance with this aspect, a therapeutically effective amount of the vaccine composition for administration to a subject to immunize against  S. aureus  infection is the amount necessary to generate a humoral (i.e., antibody mediated) immune response. The generated humoral response is sufficient to prevent or at least reduce the extent of  S. aureus  infection that would otherwise develop in the absence of such response. Preferably, administration of a therapeutically effective amount of the vaccine composition described herein induces a neutralizing immune response against  S. aureus  in the subject. To effectuate an effective immune response in a subject, the composition may further contain one or more additional  S. aureus  antigens or an adjuvant as described supra. In an alternative embodiment, the adjuvant is administered separately from the composition to the subject, either before, after, or concurrent with administration of the composition of the present invention. 
     For purposes of this aspect the disclosure, the target “subject” encompasses any animal, preferably a mammal, more preferably a human. In the context of administering a vaccine composition for purposes of preventing a  S. aureus  infection in a subject, the target subject encompasses any subject that is at risk of being infected by  S. aureus . Particularly susceptible subjects include infants and juveniles, as well as immunocompromised juvenile, adults, and elderly adults. However, any infant, juvenile, adult, or elderly adult or immunocompromised individual at risk for  S. aureus  infection can be treated in accordance with the methods and vaccine composition described herein. Particularly suitable subjects include those at risk of infection with methicillin-resistant  S. aureus  (MRSA) or methicillin sensitive  S. aureus  (MSSA). 
     Therapeutically effective amounts of the vaccine composition comprising LukA and LukB for immunization will depend on whether an adjuvant is co-administered, with higher dosages being required in the absence of adjuvant. The amount of LukAB for administration sometimes varies from 1 μg-500 μg per patient and more usually from 5-500 μg per injection for human administration. Occasionally, a higher dose of 1-2 mg per injection is used. Typically about 10, 20, 50 or 100 μg is used for each human injection. The timing of injections can vary significantly from once a day, to once a year, to once a decade. Generally an effective dosage can be monitored by obtaining a fluid sample from the subject, generally a blood serum sample, and determining the titer of antibody developed against LukAB, using methods well known in the art and readily adaptable to the specific antigen to be measured. Ideally, a sample is taken prior to initial dosing and subsequent samples are taken and titered after each immunization. Generally, a dose or dosing schedule which provides a detectable titer at least four times greater than control or “background” levels at a serum dilution of 1:100 is desirable, where background is defined relative to a control serum or relative to a plate background in ELISA assays. 
     EXAMPLES 
     Examples are provided below to illustrate the present disclosure. These examples are not meant to constrain the present disclosure to any particular application or theory of operation. 
     Example 1: Definition of a Minimal Epitope Target for mAb 5133 and mAb 5133-Based Fusion Proteins 
     The specificity of mAb 5133 for glycosylated forms of recombinant variants of the  S. aureus  SdrC protein, a member of the Serine-Aspartate Repeat (SDR) family, was previously demonstrated in a series of western blot analyses (PCT Application Publication No. WO2015089073 to Torres et al., which is hereby incorporated by reference in its entirety). Specifically, following incubation of purified, recombinant SdrC proteins with whole cell lysates prepared from  S. aureus  strain JE2 (Fey et al., “A Genetic Resource for Rapid and Comprehensive Phenotype Screening of Nonessential  Staphylococcus aureus  Genes,”  mBio  4(1):e00537-12 (2013), which is hereby incorporated by reference in its entirety), specific protein bands were detected via western blot in contrast to those detected following incubation with lysates prepared from  S. aureus  NE105, an otherwise-isogenic derivative of JE2 that lacks expression of the SdgB glycosyltransferase (PCT Application Publication No. WO2015089073 to Torres et al., which is hereby incorporated by reference). Further, incubation of purified, recombinant SdrC proteins with a recombinant form of the SdgB glycosyltransferase similarly yielded the mAb 5133 specific epitope in a manner that was dependent on the presence of uridine diphosphate N-acetylglucosamine (UDP-GlcNac) (PCT Application Publication No. WO2015089073 to Torres et al., which is hereby incorporated by reference). In order to further define a minimal epitope for mAb 5133, a synthetic peptide was employed as an in vitro substrate for the SdgB glycosyltransferase that contains ten (10) copies of the Serine-Aspartate dipeptide sequence but lacks any additional protein sequence derived from any of the five members of the SDR family of proteins of  S. aureus  (Cheng et al., “Variation of Serine-Aspartate Repeats in Membrane Proteins Possibly Contributes to Staphylococcal Microevolution,”  PLoS ONE  7(4): e34756 (2012); Becherelli et al., “Protective Activity of the CnaBE3 Domain Conserved Among  Staphylococcus aureus  Sdr Proteins,”  PLoS One  8(9): e74718 (2013), which are hereby incorporated by reference in their entirety). 
     Procedure. Recombinant variants of the  S. aureus  SDR family members Clumping Factor A (ClfA) and Clumping Factor B (ClfB) were engineered in vector pET29a(+) such that each bears an amino-terminal S-tag (Merck KGaA; Raines et al., “The S-Tag Fusion System for Protein Purification,”  Methods Enzymol.  326:362-367 (2000), which is hereby incorporated by reference in its entirety), thrombin cleavage site, a carboxyl-terminal poly-histidine affinity tag, and correspond to SEQ ID NOs: 668 and 669, respectively. These recombinant proteins were purified to apparent homogeneity following inducible over-expression in  Escherichia coli  and purification via Ni-NTA agarose resin (Qiagen 1018244) plus S•Tag™ Thrombin Purification Kit (EMD Millipore 69232). A recombinant form of the  S. aureus  SdgB glycosyltransferase bearing a C-terminal poly-histidine (His) 6  affinity tag (SEQ ID NO: 99) was similarly expressed in  E. coli  and purified via Ni-NTA affinity chromatography. For in vitro glycosylation reactions, 100 g of recombinant SDR proteins [SdrC4/SEQ ID NO: 100, ClfA/SEQ ID NO: 668 and ClfB/SEQ ID NO: 669) were incubated +/−30 μg of Uridine diphosphate N-acetylglucosamine (UDP-GlcNac), +/−4 μg of recombinant SdgB/SEQ ID NO:99 in a final volume of 100 μl 100 mM Tris pH 7.5 or 100 μl 100 mM Tris pH 7.5 plus 10% glycerol at 37 C.° for 1 hour. High binding 96-well ELISA plates (Nunc) were coated with recombinant proteins SDR proteins +/− SdgB-mediated glycosylation at 5 μg/mL in PBS and incubated overnight at 4° C. Plates were washed three times with ELISA wash buffer (0.15M NaCl, 0.02% Tween-20) and blocked with blocking buffer (Superblock Thermo 37515) for one hour at ambient temperature. In separate dilution plates, test articles were serially diluted three-fold in blocking buffer starting at 1 μM or 10 μM. ELISA plates were washed three times with ELISA wash buffer and antibody dilutions were transferred from the dilution plates to the ELISA plates and incubated for one hour at ambient temperature. ELISA plates were washed three times with ELISA wash buffer and a secondary goat anti-human Fc gamma-specific-HRP (Jackson Immunoresearch 109-035-098) was diluted 1:10,000 in blocking buffer and added to the plates. Plates were incubated with secondary antibody for one hour at ambient temperature then washed four times with ELISA wash buffer. POD Chemiluminescence substrate (Roche-cat#11582950001) was then added to the plates and absorbance was read immediately on the Perkin Elmer EnVision Multilabel Reader at 405 nm. The data were analyzed using GraphPad Prism. Values were transformed to a log scale and fit using a non-linear regression sigmoidal dose-response equation resulting in an eleven point binding curve for each antibody against each antigen. 
     For peptide studies, a twenty eight (28) residue peptide of the amino acid sequence: (N-terminus)-SDSDSDSDSDSDSDSDSDSDHHHHHHHH-(C-terminus) (SEQ ID NO: 670) was synthesized (New England Peptide, Inc., Gardner, Mass.). The peptide contains ten copies of the SD dipeptide repeat element followed by an eight residue poly-Histidine sequence and was additionally modified such as to bear an amino-terminal biotin moiety. This peptide is herein referred to as the “SD peptide” and has a measured molecular weight of 3475 Daltons. For in vitro glycosylation reactions, 100 g of the SD peptide was incubated with 4 μg of recombinant SdgB protein in 100 μl of 100 mM Tris pH 7.5 containing 10% glycerol and 30 μg of uridine diphosphate N-acetylglucosamine (UDP-GlcNac) at 37 C.° for 1 hour. Analysis of the extent of in vitro glycosylation was determined by matrix-assisted laser desorption/ionization (MALDI) analysis. The binding of mAb 5133 and mAb 5133-based fusion proteins to the SD peptide (+/− glycosylation) was determined using a plate-based ELISA format wherein the SD peptide (+/− glycosylation) was captured on high binding 96-well ELISA plates (Nunc) coated with streptavidin at 5 μg/mL in PBS and incubated overnight at 4° C. Detection of bound test articles was performed using an HRP-conjugated F(ab′)2 fragment donkey anti-human IgG (H+L) (Jackson Immunoresearch 709-006-149 lot 112932) and detection of streptavidin plate-bound SD peptide (+/− glycosylation) by use of an HRP-conjugated anti-polyhistidine antibody (R&amp;D Systems MAB050H polyhistidine HRP MAb Clone AD1.1.10). POD Chemiluminescence substrate (Roche-cat#11582950001) was then added to the plates and absorbance was read immediately on the Perkin Elmer EnVision Multilabel Reader at 405 nm. The data were analyzed using GraphPad Prism. Values were transformed to a log scale and fit using a non-linear regression sigmoidal dose-response equation resulting in an eleven point binding curve for each antibody against the SD peptide (+/− glycosylation) antigen. 
     Results. 
       FIG. 1  shows the binding of mAb 5133 (Table 1: Construct 1) to recombinant  S. aureus  SDR proteins +/− SdgB-mediated glycosylation as determined by ELISA assay.  FIG. 1A  shows specific binding of mAb 5133 to the SdgB glycosylated form of SdrC4 (SEQ ID NO: 100) as previously reported based on western blot analyses (PCT Application Publication No. WO2015089073 to Torres et al., which is hereby incorporated by reference). Similarly,  FIGS. 1B and 1C  show specific binding of mAb 5133 to the SdgB glycosylated forms of two additional  S. aureus  SDR proteins, ClfA (SEQ ID NO: 668) ( FIG. 1B ) and ClfB (SEQ ID NO: 669) ( FIG. 1C ) with no apparent binding to the purified, recombinant proteins as prepared from  E. coli . These data further substantiate that the antigen epitope recognized by mAb 5133 is a specifically glycosylated form of the SDR proteins as generated by incubation of the proteins in the presence of SdgB and UDP-GlcNac. 
     MALDI analysis of in vitro SdgB-mediated glycosylation of the SD peptide revealed a series of discrete species that differ by ˜203 Daltons indicative of the addition of individual GlcNac units to Serine residues with up to ten apparent sites of glycosylation per monomer peptide. As shown in  FIG. 1D , mAb 5133 recognizes streptavidin-bound SD peptide in a concentration-dependent manner that is wholly dependent on prior glycosylation by the SdgB enzyme.  FIG. 1E  serves as a control to show that equivalent amounts of the glycosylated and non-glycosylated forms of the SD peptide are bound to the streptavidin-coated plates when detected using a HRP-conjugated anti-polyhistidine antibody.  FIG. 1F  shows the binding of a series of mAb 5133-based fusion proteins to the SdgB glycosylated SD peptide immobilized on plates via streptavidin capture. Importantly, these data indicate that the fusion of dual, tandem FN3 domains (Table 1: Constructs 11, 12, 13 &amp; 14) to the carboxyl-terminus of the heavy chain portion of the parental mAb sequences does not have any detectable impact on the affinity of the test articles for the glycosylated SD peptide antigen as mediated by the mAb 5133 derived V-region. Further, elimination of Protein-A binding of mAb-FN3 fusion proteins (as conferred by introduction of CH3 mutations H435R/Y436F) has no detectable impact on the affinity of the test articles for the glycosylated SD peptide antigen (Table 1: Constructs 11 &amp; 12). 
     Summary. 
     These data indicate (i) that the epitope target of mAb 5133 and mAb 5133-FN3 fusion proteins can be defined minimally as a peptide sequence containing as few as ten copies of the SD repeat sequence that has been modified by the  S. aureus  SdgB glycosyltransferase in the presence of UDP-GlcNac, and (ii) that no other sequences from the SdrC protein, or other  S. aureus  SDR family members [Clumping Factor A (ClfA), Clumping Factor B (ClfB), SdrD or SdrE], are necessary components of the minimal antigen epitope recognized by mAb 5133. 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Characteristics of Antibody and Antibody-FN3 Fusion Constructs 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                   
                 Light Chain 
               
               
                 Construct 
                 SEQ ID 
                   
                   
                   
                 Heavy Chain 
                 FN3 
               
               
                 No. 
                 NO: 
                 Description 
                 V-region 
                 Heavy Chain 
                 FN3 domains 
                 domains 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 1 
                 60 HC 
                 CR5133 
                 anti- 
                 IgG1 wt 
                 none 
                 none 
               
               
                   
                 61 LC 
                   
                 glycosylated 
                   
                   
                   
               
               
                   
                   
                   
                 SDR- 
                   
                   
                   
               
               
                   
                   
                   
                 containing 
                   
                   
                   
               
               
                   
                   
                   
                 proteins 
                   
                   
                   
               
               
                 2 
                 62 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 none 
                 none 
               
               
                   
                 63 LC 
                 PRASA 
                 glycosylated 
                 L234V/ 
                   
                   
               
               
                   
                   
                   
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                   
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                   
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A 
                   
                   
               
               
                 3 
                 64 HC 
                 CR5133 A6 
                 anti- 
                 H435R/ 
                 none 
                 none 
               
               
                   
                 65 LC 
                   
                 glycosylated 
                 Y436F 
                   
                   
               
               
                   
                   
                   
                 SDR- 
                   
                   
                   
               
               
                   
                   
                   
                 containing 
                   
                   
                   
               
               
                   
                   
                   
                 proteins 
                   
                   
                   
               
               
                 4 
                 66 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 none 
                 none 
               
               
                   
                 67 LC 
                 PRASA A6 
                 glycosylated 
                 L234V/ 
                   
                   
               
               
                   
                   
                   
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                   
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                   
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 5 
                 68 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 none 
                 anti-LukD 
               
               
                   
                 69 LC 
                 PRASA A6 
                 glycosylated 
                 L234V/ 
                   
                   
               
               
                   
                   
                 LC-L4-D 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                   
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                   
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 6 
                 70 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 anti-LukAB 
                 none 
               
               
                   
                 71 LC 
                 PRASA A6 
                 glycosylated 
                 L234V/ 
                   
                   
               
               
                   
                   
                 HC-L4-AB 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                   
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                   
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 7 
                 72 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 anti-LukAB 
                 anti-LukD 
               
               
                   
                 73 LC 
                 PRASA A6 
                 glycosylated 
                 L234V/ 
                   
                   
               
               
                   
                   
                 LC-L4-D 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 HC-L4-AB 
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                   
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 8 
                 74 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 anti-LukD 
                 none 
               
               
                   
                 75 LC 
                 PRASA A6 
                 glycosylated 
                 L234V/ 
                   
                   
               
               
                   
                   
                 HC-L4-D 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                   
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                   
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 9 
                 76 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 anti-LukAB 
                 none 
               
               
                   
                 77 LC 
                 PRASA A6 
                 glycosylated 
                 L234V/ 
                 anti-LukD 
                   
               
               
                   
                   
                 HC L4-AB- 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 L4-D 
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                   
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 10 
                 78 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 anti-LukD 
                 none 
               
               
                   
                 79 LC 
                 PRASA A6 
                 glycosylated 
                 L234V/ 
                 anti-LukAB 
                   
               
               
                   
                   
                 HC L4-D- 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 L4-AB 
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                   
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 11 
                 856 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 anti-LukE 
                 none 
               
               
                   
                 67 LC 
                 PRASA A6 
                 glycosylated 
                 L234V/ 
                 anti-LukAB 
                   
               
               
                   
                   
                 HC-L4-E- 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 L4-AB 
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                   
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 12 
                 952 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 anti-LukE 
                 none 
               
               
                   
                 67 LC 
                 PRASA A6 
                 glycosylated 
                 L234V/ 
                 anti-LukAB 
                   
               
               
                   
                   
                 HC-L4-E- 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 L1-AB 
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                   
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 13 
                 965 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 anti-LukE 
                 none 
               
               
                   
                 63 LC 
                 PRASA HC- 
                 glycosylated 
                 L234V/ 
                 anti-LukAB 
                   
               
               
                   
                   
                 L4-E-L1- 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 AB-FLAG 
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                   
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 14 
                 970 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 anti-LukE 
                 none 
               
               
                   
                 63 LC 
                 PRASA HC- 
                 glycosylated 
                 L234V/ 
                 anti-LukAB 
                   
               
               
                   
                   
                 L4-E-L4- 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 AB-FLAG 
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                   
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 15 
                 848 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 anti-LukE 
                 none 
               
               
                   
                 71 LC 
                 PRASA A6 
                 glycosylated 
                 L234V/ 
                   
                   
               
               
                   
                   
                 HC-L4-E 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                   
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                   
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 16 
                 868 HC 
                 ProA3 
                 anti-Protein A 
                 E223P/ 
                 anti-LukE 
                 none 
               
               
                   
                 841 LC 
                 PRASA A6 
                   
                 L234V/ 
                 anti-LukAB 
                   
               
               
                   
                   
                 HC-L4-E- 
                   
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 L4-AB 
                   
                 deleted) 
                   
                   
               
               
                   
                   
                   
                   
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 17 
                 880 HC 
                 ProA9 
                 anti-Protein A 
                 E223P/ 
                 anti-LukE 
                 none 
               
               
                   
                 842 LC 
                 PRASA A6 
                   
                 L234V/ 
                 anti-LukAB 
                   
               
               
                   
                   
                 HC-L4-E- 
                   
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 L4-AB 
                   
                 deleted) 
                   
                   
               
               
                   
                   
                   
                   
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 18 
                 921 HC 
                 IsdB 
                 anti-IsdB 
                 E223P/ 
                 anti-LukE 
                 none 
               
               
                   
                 844 LC 
                 PRASA A6 
                 (CSD7) 
                 L234V/ 
                 anti-LukAB 
                   
               
               
                   
                   
                 HC-L4-E- 
                   
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 L4-AB 
                   
                 deleted) 
                   
                   
               
               
                   
                   
                   
                   
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 19 
                 925 HC 
                 LTA 
                 anti-LTA 
                 E223P/ 
                 anti-LukE 
                 none 
               
               
                   
                 846 LC 
                 PRASA A6 
                 (Pagibaximab) 
                 L234V/ 
                 anti-LukAB 
                   
               
               
                   
                   
                 HC-L4-E- 
                   
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 L4-AB 
                   
                 deleted) 
                   
                   
               
               
                   
                   
                   
                   
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 20 
                 927 HC 
                 RSV 
                 anti-RSV 
                 E223P/ 
                 anti-LukE 
                 none 
               
               
                   
                 843 LC 
                 PRASA A6 
                 (CNTO3930) 
                 L234V/ 
                 anti-LukAB 
                   
               
               
                   
                   
                 HC-L4-E- 
                   
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 L4-AB 
                   
                 deleted) 
                   
                   
               
               
                   
                   
                   
                   
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 21 
                 104 HC 
                 CNTO3930 
                 anti-RSV 
                 IgG1 wt 
                 none 
                 none 
               
               
                   
                 105 LC 
                   
                 (CNTO3930) 
                   
                   
                   
               
               
                 22 
                 887 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 anti-LukE 
                 none 
               
               
                   
                 71 LC 
                 PRASA HC- 
                 glycosylated 
                 L234V/ 
                 anti-LukAB 
                   
               
               
                   
                   
                 L4-E-L4-AB 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                   
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                   
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A 
                   
                   
               
               
                 23 
                 923 HC 
                 CR6526 
                 Unknown 
                 E223P/ 
                 anti-LukE 
                 none 
               
               
                   
                 845 LC 
                 PRASA A6 
                   
                 L234V/ 
                 anti-LukAB 
                   
               
               
                   
                   
                 HC-L4-E- 
                   
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 L4-AB 
                   
                 deleted) 
                   
                   
               
               
                   
                   
                   
                   
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 24 
                 918 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 anti-LukE 
                 none 
               
               
                   
                 67 LC 
                 PRASA A6 
                 glycosylated 
                 L234V/ 
                 anti-LukAB 
                   
               
               
                   
                   
                 HC-L4-E- 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 L4-AB 
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                 FLAG 
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 25 
                 919 HC 
                 cMyc 
                 anti- 
                 E223P/ 
                 anti-LukE 
                 none 
               
               
                   
                 67 LC 
                 CR5133 
                 glycosylated 
                 L234V/ 
                 anti-LukAB 
                   
               
               
                   
                   
                 PRASA A6 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 HC-L4-E- 
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                 L4-AB 
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 26 
                 920 HC 
                 cMyc 
                 anti- 
                 E223P/ 
                 anti-LukE 
                 none 
               
               
                   
                 67 LC 
                 CR5133 
                 glycosylated 
                 L234V/ 
                 anti-LukAB 
                   
               
               
                   
                   
                 PRASA A6 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 HC-L4-E- 
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                 L4-AB 
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                 FLAG 
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 27 
                 977 HC 
                 RSV 
                 anti-RSV 
                 E223P/ 
                 wt-TENCON 
                 none 
               
               
                   
                 843 LC 
                 PRASA A6 
                 (CNTO3930) 
                 L234V/ 
                   
                   
               
               
                   
                   
                 HC-L4- 
                   
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 wtTENCON 
                   
                 deleted) 
                   
                   
               
               
                   
                   
                   
                   
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 28 
                 858 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 anti-LukE 
                 none 
               
               
                   
                 67 LC 
                 PRASA A6 
                 glycosylated 
                 L234V/ 
                 anti-LukAB 
                   
               
               
                   
                   
                 HC-L4-E- 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 L4-AB 
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                   
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 29 
                 1000 HC 
                 ProA3 
                 Anti-Protein A 
                 E223P/ 
                 None 
                 None 
               
               
                   
                 841 LC 
                 PRASA A6 
                   
                 L234V/ 
                   
                   
               
               
                   
                   
                   
                   
                 L235A (G236- 
                   
                   
               
               
                   
                   
                   
                   
                 deleted) 
                   
                   
               
               
                   
                   
                   
                   
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 30 
                 1001 HC 
                 ProA3 IgG1 
                 Anti-Protein A 
                 IgG1 WT 
                 None 
                 None 
               
               
                   
                 841 LC 
                   
                   
                   
                   
                   
               
               
                 31 
                 1002 HC 
                 ProA3 
                 Anti-Protein A 
                 E223P/ 
                 None 
                 None 
               
               
                   
                 841 LC 
                 PRASA 
                   
                 L234V/ 
                   
                   
               
               
                   
                   
                   
                   
                 L235A (G236- 
                   
                   
               
               
                   
                   
                   
                   
                 deleted) 
                   
                   
               
               
                   
                   
                   
                   
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                 32 
                 1003 HC 
                 LTA IgG1 
                 Anti-LTA 
                 IgG1 WT 
                 None 
                 None 
               
               
                   
                 846 LC 
                   
                 (Pagibaximab) 
                   
                   
                   
               
               
                 33 
                 1004 HC 
                 LTA 
                 Anti-LTA 
                 E223P/ 
                 None 
                 None 
               
               
                   
                 846 LC 
                 PRASA A6 
                 (Pagibaximab) 
                 L234V/ 
                   
                   
               
               
                   
                   
                   
                   
                 L235A (G236- 
                   
                   
               
               
                   
                   
                   
                   
                 deleted) 
                   
                   
               
               
                   
                   
                   
                   
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 34 
                 1078 HC 
                 anti-LukAB 
                 anti-LukAB 
                 mIgG1 WT 
                 None 
                 None 
               
               
                   
                 1079 LC 
                 mIgG1 
                   
                   
                   
                   
               
               
                 35 
                 1080 HC 
                 anti-LukAB 
                 anti-LukAB 
                 hIgG1 Fab 
                 None 
                 None 
               
               
                   
                 1081 LC 
                 Fab 
                   
                   
                   
                   
               
               
                 36 
                 1082 HC 
                 anti-gSDR 
                 anti-gSDR 
                 hIgG1 Fab 
                 None 
                 None 
               
               
                   
                 1083 LC 
                 Fab 
                   
                   
                   
                   
               
               
                 37 
                 848 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 anti-LukE 
                 anti-LukAB 
               
               
                   
                 979 LC 
                 PRASA A6 
                 glycosylated 
                 L234V/ 
                   
                   
               
               
                   
                   
                 LC-L4-AB 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 HC-L4-E 
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                   
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
                   
                   
               
               
                 38 
                 70 HC 
                 CR5133 
                 anti- 
                 E223P/ 
                 anti-LukAB 
                 anti-LukE 
               
               
                   
                 980 LC 
                 PRASA A6 
                 glycosylated 
                 L234V/ 
                   
                   
               
               
                   
                   
                 LC-L4-E 
                 SDR- 
                 L235A (G236- 
                   
                   
               
               
                   
                   
                 HC-L4-AB 
                 containing 
                 deleted) 
                   
                   
               
               
                   
                   
                   
                 proteins 
                 S239D/ 
                   
                   
               
               
                   
                   
                   
                   
                 K326A/ 
                   
                   
               
               
                   
                   
                   
                   
                 E333A/ 
                   
                   
               
               
                   
                   
                   
                   
                 H435R/ 
                   
                   
               
               
                   
                   
                   
                   
                 Y436F 
               
               
                   
               
               
                 Abbreviations: 
               
               
                 PRASA - heavy chain mutations that eliminate GluV8-mediated protease cleavage in the hinge region; 
               
               
                 A6 - Fc region mutations that that eliminate protein-A binding; 
               
               
                 HC - heavy chain; 
               
               
                 LC - light chain. 
               
            
           
         
       
     
     Example 2: Target Antigen Engagement by mAb 5133 and mAb 5133-FN3 Fusion Proteins; Simultaneous Target Engagement, Target Binding Stoichiometry and Binding Affinity 
     The roles that individual SDR proteins and the leukotoxins LukAB and LukED play in establishing and/or maintaining  S. aureus  infections in different tissue sites is predicted to vary. In some settings, glycosylated forms of the SDR proteins may be important in serving as adhesins to host tissues or soluble factors in the systemic blood circulation or other fluids in either the host extracellular environment or sub-cellular bodies in the host intracellular environment via specific host surface receptors (Hazenbos et al., “Novel Staphylococcal Glycosyltransferases SdgA and SdgB Mediate Immunogenicity and Protection of Virulence-Associated Cell Wall Proteins,”  PLoS Pathog.  9(10):e1003653 (2013); Thomer et al., “N-Acetylglucosaminylation of Serine-Aspartate Repeat Proteins Promotes  Staphylococcus aureus  Bloodstream Infection,”  J. Biol. Chem.  289(6):3478-86 (2014), which are hereby incorporated by reference in their entirety). In contrast, the leukotoxins LukAB and LukED likely play distinct roles in mediating invasive disease through their targeted cytolytic activity against specific classes of immune cells (Yoong &amp; Torres, “The Effects of  Staphylococcus aureus  Leukotoxins on the Host: Cell Lysis and Beyond,”  Curr. Opin. Microbiol.  16(1):63-9 (2013), which is hereby incorporated by reference in its entirety). Similarly, the roles of these different virulence factors in facilitating  S. aureus  survival in, or escape from, the intracellular environment of host cells (e.g., the phagolysosome) is not fully characterized although it has been established that LukAB facilitates the escape of bacteria engulfed within human polymorphonuclear leukocytes (PMNs) (Dumont et al., “ Staphylococcus aureus  Elaborates Leukocidin AB to Mediate Escape From Within Human Neutrophils,”  Infect. Immun.  81(5):1830-41 (2013), which is hereby incorporated by reference in its entirety). Considering the possibility that both SDR family proteins and the leukotoxins LukAB and LukED are important common virulence factors in some infection settings, it was important to demonstrate that mAb 5133-FN3 fusion proteins can engage multiple protein targets simultaneously. Herein, the interaction of mAb 5133-FN3 fusion proteins with purified target antigen proteins is described as determined using the Biacore surface plasmon resonance (SPR) methodology. 
     Procedure. 
     The leukotoxin binding FN3 domains of the mAb5133-FN3 fusion proteins used in this and in other Examples described herein were developed as described in PCT Application Publication No. WO2015089073 to Torres et al., which is hereby incorporated by reference in its entirety. Characteristics of the mAB5133-FN3 fusion constructs utilized herein are provided in Table 1. In these studies mAb 5133-based mAbs and mAb-5133-FN3 fusion proteins were captured as ligands on goat anti-human Fc antibody (Jackson ImmunoResearch product #109-005-098) modified CM4 sensor chips (Biacore Life Sciences product BR-1005-34) using the Biacore T200 instrument. Binding studies employed as target analytes (i) a single SdgB glycosylated preparation of the SdrC4 protein (SEQ ID NO: 100) as the V-region target antigen referred to herein as SdrC4GlcNac, (ii) a recombinant polyhistidine-tagged variant of LukE (SEQ ID NO: 13) prepared from  S. aureus , and (iii) a recombinant polyhistidine-tagged, toxoid variant of LukAB (LukA variant of SEQ ID NO: 10 and LukB of SEQ ID NO: 11) prepared from  S. aureus  that bears an E323A mutation (DuMont et al., “Identification of a Crucial Residue Required for  Staphylococcus aureus  LukAB Cytotoxicity and Receptor Recognition,”  Infect Immun.  82(3): 1268-76 (2014), which is hereby incorporated by reference in its entirety). Binding studies employed 0. μM filtered, de-gassed PBS/Tween/EDTA, pH7.4 buffer (Bio-Rad Phosphate buffered saline, pH 7.4, 0.005% Tween 20 (GE Healthcare product BR100054), 3 mM EDTA) as both the ligand immobilization running buffer (IRB) and the Biacore running buffer (BRB). The kinetic binding data was obtained using the “single cycle kinetics” mode on the Biacore T200 instrument at an analyte flow rate of 60 μL/minute and dissociation monitored for 900 seconds. In summary, data analysis was performed by (i) subtracting the curves generated by buffer injection (average) from the reference-subtracted curves for analyte injections to correct for buffer contribution to the signal and instrument noise (Myszka, “Improving Biosensor Analysis,”  J. Mol. Recognition.  12:279-284 (1999), which is hereby incorporated by reference in its entirety) and (ii) the resulting processed data generated for kinetic and affinity determinations analyzed using the T200 BIAevaluation software with kinetic data analyzed using a simple 1:1 binding model for LukAB and LukE and a two-state model for SdrC4GlcNac (Jonsson &amp; Malmqvist, “Real Time Biospecific Interaction Analysis: The Integration of Surface Plasmon Resonance Detection, General Biospecific Interface Chemistry and Microfluidics Into One Analytical System,”  Advances in Biosensor,  2:291-336 (1992); Morton &amp; Myszka, “Kinetic Analysis of Macromolecular Interactions Using Surface Plasmon Resonance Biosensors,”  Methods in Enzymol.  295:268-294 (1998); Svitel et al., “Probing the Functional Heterogeneity of Surface Binding Sites by Analysis of Experimental Binding Traces and the Effect of Mass Transport Limitation,”  Biophysical Journal,  92:1742-1758 (2007); Drake et al., “Characterizing High-Affinity Antigen/Antibody Complexes by Kinetic- and Equilibrium-Based Methods,”  Anal Biochem  328(1):35-43 (2004), which are hereby incorporated by reference in their entirety). 
     Results. 
     Test article ligands captured on CM4 sensor chips via the goat anti-human Fc antibody were mAb 5133 PRASA A6 (Table 1: construct 4/SEQ ID NO: 66 HC plus SEQ ID NO:67 LC), mAb 5133 PRASA A6 HC-L4-AB (Table 1: construct 6/SEQ ID NO: 70 HC plus SEQ ID NO:71 LC), mAb 5133 PRASA A6 HC-L4-E (Table 1: construct 15/SEQ ID NO: 848 HC plus SEQ ID NO:71 LC) and mAb 5133 PRASA A6 HC-L4-E-L4-AB (Table 1: construct 11/SEQ ID NO:856 HC plus SEQ ID NO:67 LC). In an initial phase of target binding (Phase A), SdrC4GlcNac (glycosylated SdrC4 protein at 450 nM) was bound to the immobilized ligands until apparent saturation. As shown in the Phase A of binding in  FIG. 2A , all CM4 sensor bound ligands bound the glycosylated SdrC4 protein as reflected in the increase in Response Units (RUs) from baseline. As shown in Phase B in  FIG. 2A , addition of LukE (at 1 μM) to the flow solution resulted in further increases in RUs for test article ligands constructs 15 and 11 that bear LukE-targeted FN3 domains. Finally, as shown in the Phase C in  FIG. 2A , addition of LukAB (at 100 nM) to the flow solution resulted in further increases in the observed RUs for test article construct 6 (mAb 5133 PRASA A6 HC-L4-AB) and construct 11 (mAb 5133 PRASA A6 HC-L4-E-L4-AB); again, this was expected as they each bear LukAB-targeted FN3 domains. In contrast, no apparent binding of LukAB by construct 4 (mAb 5133 PRASA A6) or construct 15 (mAb 5133 PRASA A6 HC-L4-E) was detected, consistent with the absence of LukAB-targeted FN3 domains in these proteins. 
     Analysis of these binding data allows for the quantitative assessment of the binding stoichiometry of each target antigen and these data are shown in  FIG. 2B . In all cases wherein the test articles contained a FN3 domain specific for LukE, a binding stoichiometry of &gt;1 (range of 1.2-1.5) was observed indicating that some portion of the total immobilized ligands engaged two copies of the LukE antigen simultaneously. Similarly, in all cases wherein the test articles contained a FN3 domain specific for LukAB, a binding stoichiometry of &gt;1 (range of 1.4-1.8) was observed indicating that some portion of the total immobilized ligands engaged two copies of the LukAB antigen simultaneously. 
     Finally, analysis of these binding data also allows for the determination of the binding affinity of each target antigen and these data are shown in  FIG. 2C . For test articles bearing the mAb5133-derived V-region, the affinity of binding to the glycosylated SdrC4 protein was observed to be fairly consistent with K D  values in the 0.63-0.99 nM range. Similarly, for test articles containing a FN3 domain specific for LukE, the affinity of binding to LukE was observed to be fairly consistent with K D  values in the 0.88-1.01 nM range. In contrast, for test articles containing a FN3 domain specific for LukAB, the binding affinity of Construct 11 (12 pM) was determined to be approximately six-fold higher than that observed for Construct 6 (70 pM). These data indicate that local sequence context can impact the affinity of FN3 domains for target antigens. Specifically, the affinity of the Luk17 FN3 domain appears to be enhanced when appended downstream of Luk26 in Construct 11 (mAb 5133 PRASA A6 HC-L4-E-L4-AB) when compared to its appendage to the carboxyl-terminus of mAb 5133 in Construct 6 (mAb 5133 PRASA A6 HC-L4-AB). Changes in the affinity of FN3 binding domains for their target antigens based on their local sequence context in mAb-FN3 fusion proteins are non-obvious and cannot be predicted a priori. 
     Summary. 
     These data provide evidence that mAb 5133-FN3 fusion proteins targeting LukAB and LukE can engage both toxin targets simultaneously while engaged via the V-region of the antibody portion with the SD-GlcNac antigen. This feature of mAb 5133-FN3 fusion proteins may be of significance in host tissues and/or organelles in some disease states mediated by  S. aureus  wherein roles for the glycosylated forms of the SDR family of adhesin proteins plus leukotoxins AB and/or ED are important in establishing and/or maintaining infection. Similarly, the apparent ability of mAb 5133-FN3 fusion proteins to bind both LukAB and LukE simultaneously may also be important in  S. aureus  disease states where both leukotoxins are expressed. The apparent binding stoichiometry of &gt;1 for each toxin target antigen would presumably enable higher neutralization than afforded if the binding of a single LukAB molecule precluded binding of a second LukAB molecule or the binding of a single LukE molecule precluded binding of a second LukE molecule. Finally, the observation that the context of a FN3 domain in mAb-FN3 fusion proteins can have a significant impact on target affinity suggests that target engagement of mAb-FN3 fusion proteins may be optimized through modulating sequence context through exploring appendage at different positions to the light and/or heavy chains of the mAb and through exploring FN3 domain order in mAb-FN3 fusion proteins bearing tandem FN3 domains. Each of these findings was unexpected and could not be predicted a priori. 
     Example 3: Target Engagement by mAb 5133-FN3 Fusion Proteins: The Affinity of the FN3 Components for Leukotoxin Targets and In Vivo Efficacy can be Modulated by Alteration of Linker Lengths 
     The length and nature of the linker sequences used in multi-specific fusion proteins can affect the activity and/or in vivo efficacy of the individual components, presumably by altering target (antigen) interactions and/or factors that influence in vivo pharmacokinetics-pharmacodynamics (PK-PD). Described herein is the synthesis and characterization of a series of 24 derivatives of a single mAb 5133-FN3 fusion protein (Construct 11 in Table 1; SEQ ID NO: 856 HC plus SEQ ID NO:67 LC), where the linker length between the carboxyl-terminus of the mAb heavy chain and the first FN3 domain (targeting LukE) is varied from zero to four copies of the G 4 S linker (hereinafter referred to as ‘Linker 1’), and similarly, the linker length between the carboxyl-terminus of the first FN3 domain (targeting LukE) and the amino-terminus of the second FN3 domain (targeting LukAB) is varied from zero to four copies of the G 4 S linker (hereinafter referred to as ‘Linker 2’). 
     Procedure. 
     Derivatives of the mAb 5133-FN3 fusion protein Construct 11 (CR5133 PRASA A6 HC-L4-E-L4-AB; SEQ ID NO:856 HC plus SEQ ID NO:67 LC) with variable linker lengths were synthesized by standard molecular methods and purified proteins prepared from transiently transfected Human Embryonic Kidney (HEK) 293 cells. The binding affinity of each leukotoxin target, i.e., LukE (SEQ ID NO: 13), and a LukAB toxoid variant (SEQ ID NOs: 10 and 11) that bears a mutation corresponding to E323A in the wild-type toxin (DuMont et al., “Identification of a Crucial Residue Required for  Staphylococcus aureus  LukAB Cytotoxicity and Receptor Recognition,”  Infect Immun.  82(3): 1268-76 (2014), which is hereby incorporated by reference in its entirety), was determined by ELISA. Briefly, 100 μl of a 5 μg/mL solution of streptavidin (in PBS) was added per well of a 96 well White Maxisorp plate (Nunc-cat#436110) and incubated overnight at 4° C. Wells were washed 3× with TBST (50 mM Tris HCl, pH 7.4, 150 mM NaCl, 0.1% Tween 20) and blocked with 300 μL/well with StartingBlock T20 (Pierce cat#37543) and incubated 45-60 minutes at room temperature (RT). The plate was washed 3 times with TBST and 0.2 μg of biotinylated versions of the leukotoxin target antigens (in 100 μL) added to each test well and the plate incubated 45-60 minutes at RT with gentle shaking. The plate was washed 3 times with TBST. In separate dilution plates, test articles were serially diluted three-fold in blocking buffer starting at 10 μM. ELISA plates were washed three times with ELISA wash buffer and antibody dilutions were transferred from the dilution plates to the ELISA plates and incubated for one hour at ambient temperature with gentle shaking. ELISA plates were washed three times with ELISA wash buffer and a secondary goat anti-human Fc gamma-specific-HRP (Jackson Immunoresearch 109-035-098) was diluted 1:10,000 in blocking buffer and added to the plates. Plates were incubated with secondary antibody for one hour at ambient temperature then washed four times with ELISA wash buffer. POD Chemiluminescence substrate (Roche-cat#11582950001) was then added to the plates and absorbance was read immediately on the Perkin Elmer EnVision Multilabel Reader at 405 nm. The data were analyzed using GraphPad Prism. Values were transformed to a log scale and fit using a non-linear regression sigmoidal dose-response equation resulting in an eleven point binding curve for each antibody against each antigen. 
     A mouse model of  S. aureus  kidney infections was used to assess the relative in vivo efficacy of the mAb-FN3 fusion linker variants. Briefly, female 5-6 week old Swiss Webster ND4 mice (Harlan Laboratories, Indianapolis, Ind.) were administered test articles (8 per group) via intra-peritoneal (IP injection) 24 hours prior to infection. Mice were subsequently infected with a pre-determined fixed concentration (˜10{circumflex over ( )}6 Log 10 CFU per mouse) of  S. aureus  Newman injected in a 100 μL volume retro-orbitally (under isoflurane anesthesia) using a 28 G, ½ inch needle. This concentration corresponded to the lowest bacterial inoculum that typically yields a robust kidney infection as defined by the resulting bacterial burden based on determinations of colony forming units (CFUs) measured from homogenates of explanted kidneys and the visual observation and enumeration of kidney surface abscess lesions. In all cases, test articles were administered 24 hours prior to infection. Mice were euthanized, and kidneys harvested 96 hour post infection. Kidneys were scored for severity of infection via visual lesion count. The kidneys were explanted, weighed, homogenized, and the resulting homogenates serially diluted and plated on bacterial growth media (Tryptic Soy Agar (TSA)) to determine terminal viable bacterial burdens per individual kidneys via the CFU endpoint. Mice were monitored daily for health observations. The kidney severity abscess score was recorded as: 1-2 visible lesions=severity score 1, 3-9 visible lesions=severity score 2, and &gt;=10 visible lesions=severity score 3. 
     Results. 
     The influence of varying linker lengths on leukotoxin binding affinity could not be predicted a priori and the data in  FIG. 3A  exemplifies the nonobvious impact that such variations of Linker 1 and Linker 2 have on the binding affinity for both toxin antigens. For instance, with regard to Linker position 1, variants with no copies of the G 4 S linker (0×0, 0×1, 0×2, 0×3 and 0×4) between the carboxyl-terminus of the mAb heavy chain and the first FN3 domain (targeting LukE) exhibit near equivalent binding affinities for LukE and LukAB as the 4×4 variant with the exception that the 0×0 variant exhibits somewhat weaker binding to LukAB. In contrast, with regard to Linker position 2, variants with no copies of the G 4 S linker (0×0, 1×0, 2×0, 3×0 and 4×0) between the carboxyl-terminus of the first FN3 domain (targeting LukE) and the amino-terminus of the second FN3 domain (targeting LukAB) all exhibit significantly reduced binding to LukAB when compared to the 4×4 variant, and variable reductions in affinity for binding to LukE compared to the 4×4 variant with the exception of the 0×0 variant. Overall, the lack of discernible trends between toxin binding affinities and the lengths of Linker 1 and Linker 2 highlights the impact that each linker can have on the binding to each of the toxin targets, and therefore, the need to neutrally assess a broad panel of linker variants in optimizing these mAb-FN3 fusion proteins with regard to their binding affinities for the toxin targets. 
     Similarly, the influence of varying linker lengths on in vivo efficacy could not be predicted a priori and the data in  FIGS. 3B, 3C, and 3D  exemplifies the nonobvious impact that such variations of Linker 1 and/or Linker 2 have on the efficacy in a mouse model of  S. aureus  kidney infections. For instance, the 1×4 and 4×4 variants exhibit equivalent (high) efficacy and retain potent binding to both LukE and LukAB ( FIGS. 3C and 3D , respectively). In contrast, while the 3×2, 3×3 and 3×4 variants exhibit potent binding to both LukE and LukAB, they exhibit weak or no in vivo efficacy ( FIGS. 3C and 3D , respectively). Hence, the relationship between linker length and efficacy cannot simply be explained by changes in toxin binding affinity as differences in linker composition will likely impact factors that influence in vivo pharmacokinetics-pharmacodynamics (PK-PD). Again, these data highlight the need to neutrally assess a broad panel of linker variants in optimizing these mAb-FN3 fusion proteins with regard to in vivo efficacy. 
     Summary. 
     The influence of varying linker lengths of mAb 5133-FN3 fusion proteins on in vitro and in vivo activities could not be predicted a priori. As exemplified herein through studies of leukotoxin target binding, toxin neutralization and in vivo efficacy of a broad panel of linker variants of a single mAb 5133-FN3 fusion protein, the nonobvious impact that such variations of Linker 1 and/or Linker 2 have on in vitro, ex vivo and in vivo activity was borne out. These studies highlight the potential for optimizing the activity of mAb 5133-FN3 fusion proteins through varying the G 4 S linker length employed between the carboxyl-terminus of the mAb heavy chain and the first FN3 domain and, where relevant, the linker length between the carboxyl-terminus of the first FN3 domain and the amino-terminus of the second FN3 domain. 
     Example 4: Correlation of Toxin Binding and Neutralizing Activity of FN3 Variants Targeting the LukE Component of Leukotoxin LukED 
     The specificity in leukotoxin binding and neutralization observed for some FN3 variants implies that they interact in a highly specific manner. In an effort to define key molecular interactions between the FN3 protein and the LukE subunit, mutant derivatives of a series of three LukE-specific FN3 variants, specifically Luk26 (SEQ ID NO: 25), Luk27 (SEQ ID NO: 26) and Luk38 (SEQ ID NO: 37) were prepared in which residues that differ from the parental, wild-type TENCON FN3 protein (SEQ ID NO: 1) were each individually changed to Alanine to create a so-called ‘Alanine Scan’ set of variants across the putative LukE binding surface. Each variant was then assessed for (i) retention of binding to purified, recombinant LukE protein as determined in an ELISA format assay, and (ii) for LukED toxin neutralization activity in assays employing isolated primary human neutrophils. 
     Procedure. 
     Binding of the FN3 variants to purified, recombinant LukE protein (SEQ ID NO: 13) was determined by ELISA. Briefly, 100 μl of a 5 μg/mL solution of streptavidin (in PBS) was added per well of a 96 well White Maxisorp plate (Nunc-cat#436110) and incubated overnight at 4° C. Wells were then washed 3× with TBST (50 mM Tris HCl, pH 7.4, 150 mM NaCl, 0.1% Tween 20) and blocked with 300 μL/well with StartingBlock T20 (Pierce cat#37543) and incubated 45-60 minutes at room temperature (RT). The plate was then washed 3 times with TBST and 0.2 μg of a biotinylated preparation of LukE protein (in 100 μL) was added to each test well and the plate incubated 45-60 minutes at RT with gentle shaking. The plate was then washed 3 times with TBST. In separate dilution plates, test articles were serially diluted three-fold in blocking buffer starting at 1 μM. 100 μL of titrated test articles were added to test wells and the plate incubated 45-60 minutes at RT with gentle shaking. The plate was then washed 3 times with TBST. For detection of bound test articles, 100 μL/well of a polyclonal anti-FN3-HRP antibody diluted 1:5000 in Starting block T20 was added and the plate incubated for 45-60 min at RT with gentle shaking. The plate was then washed 3 times with TBST. To detect bound anti-FN3-HRP antibody, 100 μL/well of the POD Chemiluminescence substrate (Roche-cat#11582950001) was added immediately prior to reading plates and the plates read using a Paradigm or Envision reader within 15 minutes of the substrate addition. The data were analyzed using GraphPad Prism. Values were transformed to a log scale and fit using a non-linear regression sigmoidal dose-response equation resulting in an eleven point binding curve for each antibody against each antigen. 
     For LukED neutralization studies, the FN3 domain test articles (10 μg/mL in 100 μL reactions were incubated with purified, recombinant LukED (SEQ ID NOs: 12 &amp; 13) for 30 mins at 4° C. Freshly isolated human primary polymorphonuclear leukocytes (hPMNs, 200,000 cells in RPMI+10 mM HEPES+0.1% HSA) were added to the mixture of toxin and FN3 domain protein to a final volume of 100 μl. Ethidium bromide was then added to the cells at 1:2000 final dilution and plates were read 30 and 60 mins post toxin addition. Following 1 hour intoxication in a 37° C. CO 2  incubator, 25 μl of supernatant was carefully transferred to a new plate after spinning the plate down at 1500 RPM for 10 mins. Cell Titer reagent (Promega) was added to the remaining cells and incubated for 1.5 hours. The 25 μl of supernatant were mixed with equal amounts of CytoTox-ONE™ Assay reagent (Promega) that rapidly measures the release of lactate dehydrogenase (LDH) from cells with a damaged membrane. LDH released into the culture medium was measured with a 10-minute coupled enzymatic assay that results in the conversion of resazurin into a fluorescent resorufin product. For the neutralization experiments, LukED was used at a concentration of 72.5 nM (2.5 μg/mL per subunit). 
     Results. 
     As shown in  FIG. 4A , there appears to be a reasonable correlation between LukE binding affinity and LukED toxin neutralization activity (as represented via the Cell Titer endpoint) in the ‘Alanine scan’ set of derivatives of the Luk26 FN3 protein. In no instance was LukE binding retained and neutralization lost. In contrast, two variants (W39A and W41A) exhibited a near total loss of LukE binding and LukED neutralization while other variants (e.g., E34A, F70A and G72A) exhibited reduced binding affinity and partial loss of LukED neutralization activity. These data identify key residues that appear to mediate highly specific LukE binding by Luk26 and therein define components of the FN3 paratope. 
     Similarly, as shown in  FIG. 4B , there appears to be a reasonable correlation between LukE binding affinity and LukED toxin neutralization activity (as represented via the Cell Titer endpoint) in the ‘Alanine scan’ set of derivatives of the Luk27 FN3 protein. Again, in no instance was LukE binding retained and neutralization lost. In contrast, one variant (D70A) exhibited a near total loss of LukE binding and LukED neutralization while other variants (e.g., W38A, L68A, Y72A, W79A and Y81A) exhibited reduced binding affinity and partial loss of LukED neutralization activity. These data identify key residues that appear to mediate highly specific LukE binding by Luk27 and therein define components of the FN3 paratope. 
     Finally, as shown in  FIG. 4C , there appears to be a reasonable correlation between LukE binding affinity and LukED toxin neutralization activity (as represented via the Cell Titer endpoint) in the ‘Alanine scan’ set of derivatives of the Luk38 FN3 protein. Two variants (W81A and D83A) exhibited a near total loss of LukE binding and LukED neutralization while another variant (F86A) exhibited reduced binding affinity and partial loss of LukED neutralization activity. In other variants (e.g., I77A, G80A, F84A, V85A and F86A), LukE binding appeared to be significantly retained while LukED neutralization activity was significantly reduced. These data identify key residues that appear to mediate highly specific LukE binding by Luk38 and therein define components of the FN3 paratope. 
     Summary. 
     These data show that the Luk26, Luk27 and Luk38 FN3 domain proteins bind and neutralize LukED through a series of specific molecular interactions at their respective paratope-epitope surfaces. Further, the identification of residues in these LukE-specific FN3 proteins that when mutated to Alanine have no apparent impact on either LukE binding or LukED neutralization provides opportunities to further enhance the potency of LukE binding and LukED neutralization by changing these residues to alternate amino acids. 
     Example 5: Correlation of Toxin Binding and Neutralizing Activity of an FN3 Variant Targeting Leukotoxin LukAB 
     The specificity in leukotoxin binding and neutralization observed for some FN3 variants implies that they interact in a highly specific manner. In an effort to define key molecular interactions between the FN3 protein and the LukAB toxin, mutant derivatives of Luk17 (SEQ ID NO: 14) were prepared in which residues that differ from the parental, wild-type TENCON FN3 protein (SEQ ID NO: 1) were each individually changed to Alanine to create a so-called ‘Alanine Scan’ set of variants across the putative LukAB binding surface. Each variant was then assessed for (i) retention of binding to purified, recombinant LukAB protein as determined in an ELISA format assay, and (ii) for LukAB toxin neutralization activity in assays employing isolated primary human neutrophils. 
     Procedure. 
     Binding of the FN3 variants to a purified, recombinant polyhistidine-tagged, toxoid variant of LukAB (SEQ ID NOs: 10 and 11) prepared from  S. aureus  that bears a mutation corresponding to E323A in the wild-type toxin sequence (DuMont et al., “Identification of a Crucial Residue Required for  Staphylococcus aureus  LukAB Cytotoxicity and Receptor Recognition,”  Infect. Immun.  82(3): 1268-76 (2014), which is hereby incorporated by reference in its entirety) was determined by ELISA. Briefly, 100 μl of a 5 μg/mL solution of streptavidin (in PBS) was added per well of a 96 well White Maxisorp plate (Nunc-cat#436110) and incubated overnight at 4° C. Wells were then washed 3× with TBST (50 mM Tris HCl, pH 7.4, 150 mM NaCl, 0.1% Tween 20) and blocked with 300 μL/well with StartingBlock T20 (Pierce cat#37543) and incubated 45-60 minutes at room temperature (RT). The plate was then washed 3 times with TBST and 0.2 μg of a biotinylated preparation of LukAB (E323A) protein (in 100 μL) was added to each test well and the plate incubated 45-60 minutes at RT with gentle shaking. The plate was then washed 3 times with TBST. In separate dilution plates, test articles were serially diluted three-fold in blocking buffer starting at 10 μM. 100 μL of titrated test articles were added to test wells and the plate incubated 45-60 minutes at RT with gentle shaking. The plate was then washed 3 times with TBST. For detection of bound test articles, 100 μL/well of a polyclonal anti-FN3-HRP antibody diluted 1:5000 in Starting block T20 was added and the plate incubated for 45-60 min at RT with gentle shaking. The plate was then washed 3 times with TBST. To detect bound anti-FN3-HRP antibody, 100 μL/well of the POD Chemiluminescence substrate (Roche-cat#11582950001) was added immediately prior to reading plates and the plates read using a Paradigm or Envision reader within 15 minutes of the substrate addition. The data were analyzed using GraphPad Prism. Values were transformed to a log scale and fit using a non-linear regression sigmoidal dose-response equation resulting in an eleven point binding curve for each antibody against each antigen. 
     For LukAB toxin neutralization studies, the FN3 domain test articles (40 μg per mL in a 100 μL reaction volume were incubated with purified, recombinant LukAB (SEQ ID NOs: 671 &amp; 11) for 30 mins at 4° C. Freshly isolated human polymorphonuclear neutrophils (hPMNs, 200,000 cells in RPMI+10 mM HEPES+0.1% HSA) were added to the mixture of toxin and FN3 domain protein to a final volume of 100 μl. Ethidium bromide was then added to the cells at 1:2000 final dilution and plates were read 30 and 60 mins post toxin addition. Following 1 hour intoxication in a 37° C. CO 2  incubator, 25 μl of supernatant was carefully transferred to a new plate after spinning the plate down 1500 RPM for 10 mins. Cell Titer reagent (Promega) was added to the remaining cells and incubated for 1.5 hours. The 25 μl of supernatant were mixed with equal amounts of CytoTox-ONE™ Assay reagent (Promega) that rapidly measures the release of lactate dehydrogenase (LDH) from cells with a damaged membrane. LDH released into the culture medium was measured with a 10-minute coupled enzymatic assay that results in the conversion of resazurin into a fluorescent resorufin product. For the neutralization experiments, LukAB was used at a final concentration of 33.75 nM (1.25 μg/mL of each subunit). 
     Results. 
     As shown in  FIG. 5 , there appears to be a good correlation between LukAB binding affinity and LukAB toxin neutralization activity (as represented by the ethidium bromide uptake endpoint) in the ‘Alanine scan’ set of derivatives of the Luk17 FN3 protein. In no instance was significant LukAB binding retained and toxin neutralization lost. In contrast, a series of variants (E36A, K38A, F39A, R41A and W70A) exhibited a near total loss of LukAB binding and LukAB neutralization while other variants (W32A, Y40A, K68A and W81A) exhibited reduced binding affinity and partial loss of LukED neutralization activity. These data identify key residues that appear to mediate highly specific LukAB binding by Luk17 and therein define components of the FN3 paratope. 
     Summary. 
     These data show that the Luk17 FN3 domain protein binds and neutralizes LukAB through a series of specific molecular interactions at the paratope-epitope surface. Further, the identification of residues in Luk17 that when mutated to Alanine have no apparent impact on either LukAB binding or neutralization provides opportunities to further enhance the potency of LukAB binding and neutralization by changing these residues to alternate amino acids. 
     Example 6: mAb 5133-FN3 Fusion Proteins have Improved Efficacy Compared to mAb-5133 in a Mouse Kidney Infection Model 
     In understanding the relative contributions of the variable (V) region and/or the anti-toxin FN3 components of mAb 5133-based FN3 fusion proteins with regard to efficacy in animal models of human  S. aureus  infections, a series of test articles were compared with regard to their relative efficacy in a mouse renal (kidney) infection model of disease. Specifically, a series of test articles were evaluated “head-to-head” that bear the same mAb 5133-derived V-region (targeting glycosylated forms of the SDR family of adhesins) but differ in their FN3 domain composition with regard to targeting of LukE alone or LukE and LukAB in combination. As an isotype IgG1 control, non-antistaphylococcal antibody, CNTO3930 (Construct 21 in Table 1; SEQ ID NO:104 HC plus SEQ ID NO:105 LC) was employed that targets the respiratory syncytial virus F (RSV-F) protein. 
     Procedure. 
     Female 5-6 week old Swiss Webster ND4 mice (Harlan Laboratories, Indianapolis, Ind.) were administered test articles (8 per group) via intra-peritoneal (IP) injection in a fixed dose volume of 200 μL/mouse 24 hours prior to infection. Mice were subsequently infected with a pre-determined fixed concentration (˜6.7×10{circumflex over ( )}6 Log 10  CFU per mouse) of  S. aureus  Newman (Baba et al., “Genome Sequence of  Staphylococcus aureus  Strain Newman and Comparative Analysis of Staphylococcal Genomes: Polymorphism and Evolution of Two Major Pathogenicity Islands,”  J Bacteriol.  190(1):300-310 (2008), which is hereby incorporated by reference in its entirety) injected in a 100 μL volume retro-orbitally (under isoflurane anesthesia) using a 28 G, ½ inch needle. This infectious dose corresponds to the lowest bacterial inoculum that typically yields a robust kidney infection as defined by the resulting bacterial burden. Bacterial burden is determined by colony forming units (CFUs) measured from homogenates of explanted kidneys and the visual observation and enumeration of kidney surface lesions. In all cases, test articles were administered 24 hours prior to infection and mice euthanized and kidneys harvested 96 hour post infection. Mice were monitored daily for health observations. Kidneys were scored for severity of infection via visual lesion (abscess) count with the aid of a dissecting microscope, and then explanted, weighed, homogenized, and the resulting homogenates serially diluted and plated on bacterial growth media (Tryptic Soy Agar (TSA)) to determine terminal viable bacterial burdens per individual kidneys via the CFU endpoint. Mice were monitored daily for health observations. Statistical analysis of both the lesion data and bacterial burden (CFU) data was performed by calculating p-values using the Dunn&#39;s Method. Test articles evaluated were CNTO3930 (Construct 21 in Table 1; SEQ ID NO:104 HC plus SEQ ID NO:105 LC), mAb 5133 PRASA A6 (Construct 4 in Table 1; SEQ ID NO:66 HC plus SEQ ID NO:67 LC), mAb 5133 PRASA A6 HC-L4-E (Construct 15 in Table 1; SEQ ID NO:848 HC plus SEQ ID NO:71 LC) and mAb 5133 PRASA A6 HC-L4-E-L4-AB (Construct 11 in Table 1; SEQ ID NO:856 HC plus SEQ ID NO:67 LC). All test articles were administered IP at a dose of 500 μg per animal 24 hours prior to infection. 
     Results. 
       FIG. 6  shows the reductions in kidney severity scores, the total kidney surface lesions per group and the viable bacterial burdens per individual kidneys recovered for each dosed animal. As expected, treatment with the isotype control anti-RSV antibody (CNTO3930, Lane 1) resulted in the highest mean bacterial burden in the kidneys with a mean log 10 CFU/g kidney of 7.0 and with the highest visual evidence of lesions on each kidney harvested from the group of eight animals (16/16). Treatment with mAb 5133 PRASA A6 (Lane 2), reduced the bacterial burden in the kidney by minus 0.8 log 10 CFU/g compared to CNTO3930 and lowered kidney lesion incidence to 50% (8/16). Treatment with mAb 5133 PRASA A6 HC-L4-E (Lane 3) further reduced the bacterial burden in the kidney, specifically minus 1.8 log 10  CFU/g compared to CNTO3930 and lowered the kidney lesion incidence further to 25% (4/16). However, treatment with mAb 5133 PRASA A6 HC-L4-E-L4-AB (Lane 4) resulted in the highest overall efficacy as determined by either the bacterial burden in the kidney or lesion incidence. Specifically, treatment with mAb 5133 PRASA A6 HC-L4-E-L4-AB further reduced the bacterial burden in the kidney by minus 2.6 log 10  CFU/g compared to CNTO3930 and reduced kidney lesion incidence beyond the limit of detection (0/16). 
     Summary. 
     These data show that both the V-region and anti-toxin FN3 components of mAb5133-based FN3 fusion proteins are important contributors towards the overall efficacy observed in this mouse model of kidney infection. Treatment with mAb 5133 PRASA A6 resulted in efficacy improved over the non-antistaphylococcal mAb (CNTO3930) with a reduction in kidney lesion incidence of 50% and a reduced bacterial burden in the kidney of minus 0.8 log 10  CFU/g tissue. However, addition of a single FN3 fusion protein targeting LukE as exemplified in mAb 5133 PRASA A6 HC-L4-E resulted in a further reduction in kidney lesion incidence (25%) and a further reduction in bacterial burden in the kidney of minus 1.8 log 10  CFU/g tissue. However, addition of dual, tandem FN3 fusion proteins targeting LukE and LukAB as exemplified in mAb 5133 PRASA A6 HC-L4-E-L4-AB resulted in the highest overall reduction in bacterial burden in the kidney (minus 2.6 log 10  CFU/g tissue compared to CNTO3930) and a reduction in kidney lesion incidence beyond the limit of detection (0/16). In toto, these data suggest that both the V-region and anti-toxin FN3 components of mAb5133-based FN3 fusion proteins contribute towards efficacy in this mouse kidney infection model and further that mAb5133-based FN3 fusion proteins targeting both LukE and LukAB exhibit the best overall efficacy. Finally, these data suggest that the antigenic target of mAb 5133 (glycosylated forms of the SDR family of adhesins) and leukotoxins ED and AB are all contributory virulence factors in this mouse kidney infection model. 
     Example 7: mAb 5133 and mAb 5133-FN3 Fusion Proteins Exhibit Improved Efficacy in a Murine Renal Abscess Infection Model Compared to mAbs or mAb-FN3 Fusion Proteins Targeting Non-SDR  S. aureus  Protein Antigens 
     In understanding the relative contributions of the V-region and/or the anti-leukotoxin FN3 components of mAb 5133-based FN3 fusion proteins with regard to efficacy in animal models of human  S. aureus  infections, a series of test articles were compared for their relative efficacy in a mouse renal (kidney) infection model of disease. Specifically, a series of test articles were evaluated “head-to-head” which differ only in their V-region component but are otherwise identical in their anti-toxin FN3 components as fused to the heavy chain of the mAb entity of the mAb-FN3 fusion protein. These included anti-staphylococcal antibodies targeting the iron regulated surface determinant  B  (IsdB) protein, (Ebert et al., “A Fully Human Monoclonal Antibody to  Staphylococcus aureus  Iron Regulated Surface Determinant B (IsdB) With Functional Activity In Vitro and In Vivo,”  Human Antibodies  19(4): 113-28 (2010); Pancari et al., “Characterization of the Mechanism of Protection Mediated by CS-D7, a Monoclonal Antibody to  Staphylococcus aureus  Iron Regulated Surface Determinant B (IsdB),”  Frontiers in Cellular and Infection Microbiology  2(36): 1-13 (2012), which are hereby incorporated by reference in their entirety), the immunoglobulin-G binding protein Protein-A, lipoteichoic acid (Weisman et al., “Phase 1/2 Double-Blind, Placebo-Controlled, Dose Escalation, Safety, and Pharmacokinetic Study of Pagibaximab (BSYX-A110), an Antistaphylococcal Monoclonal Antibody for the Prevention of Staphylococcal Bloodstream Infections, in Very-Low-Birth-Weight Neonates,”  Antimicrob Agents  &amp;  Chemotherapy  53(7):2879-86 (2009), which is hereby incorporated by reference in its entirety) or an uncharacterized  S. aureus  cell surface antigen (mAb CR6526-based FN3 fusion protein). As controls, the anti-RSV V-region derived from CNTO3930 that targets the respiratory syncytial virus F (RSV-F) protein was included in the context of both a mAb-FN3 fusion protein and as an isotype IgG1 control antibody, CNTO3930. 
     Procedure. 
     Female 5-6 week old Swiss Webster ND4 mice (Harlan Laboratories, Indianapolis, Ind.) were administered test articles (8 per group) via intra-peritoneal (IP injection) 24 hours prior to infection. Mice were subsequently infected with a pre-determined fixed concentration (˜10{circumflex over ( )}6 Log 10 CFU per mouse) of  S. aureus  Newman (Baba et al., “Genome Sequence of  Staphylococcus aureus  Strain Newman and Comparative Analysis of Staphylococcal Genomes: Polymorphism and Evolution of Two Major Pathogenicity Islands,”  J Bacteriol.  190(1):300-310 (2008), which is hereby incorporated by reference in its entirety) injected in a 100 μL volume retro-orbitally (under isoflurane anesthesia) using a 28 G, ½ inch needle. The administered concentration corresponds to the lowest bacterial inoculum that typically yields a robust kidney infection as defined by the resulting bacterial burden. Bacterial burden is determined by colony forming units (CFUs) measured from homogenates of explanted kidneys and the visual observation and enumeration of kidney surface lesions. In all cases, test articles were administered 24 hours prior to infection and mice euthanized and kidneys harvested 96 hour post infection. Kidneys were scored for severity of infection via visual lesion count. The kidneys were then explanted, weighed, homogenized, and the resulting homogenates serially diluted and plated on bacterial growth media (Tryptic Soy Agar (TSA)) to determine terminal viable bacterial burdens per individual kidneys via the CFU endpoint. Mice were monitored daily for health observations. The kidney severity abscess score was recorded as: 1-2 visible lesions=severity score 1, 3-9 visible lesions=severity score 2, and &gt;=10 visible lesions=severity score 3. Statistical analysis of both the lesion data and bacterial burden (CFU) data was performed by calculating p-values using the Dunn&#39;s Method. Test articles evaluated were CNTO3930 (Construct 21 in Table 1; SEQ ID NO:104 HC plus SEQ ID NO:105 LC), mAb 5133 PRASA A6 (Construct 4 in Table 1; SEQ ID NO:66 HC plus SEQ ID NO:67 LC), ProA3 PRASA A6 HC-L4-E-L4-AB (Construct 16 in Table 1; SEQ ID NO:HC 868 plus SEQ ID NO:841 LC), ProA9 PRASA A6 HC-L4-E-L4-AB (Construct 17 in Table 1; SEQ ID NO:HC 880 plus SEQ ID NO:842 LC), IsdB PRASA A6 HC-L4-E-L4-AB (Construct 18 in Table 1; SEQ ID NO:HC 921 plus SEQ ID NO:844 LC), mAb 6526 PRASA A6 HC-L4E-L4-AB (Construct 23 in Table 1; SEQ ID NO:HC 923 plus SEQ ID NO: 845 LC), RSV PRASA A6 HC-L4-E (Construct 20 in Table 1; SEQ ID NO:927 HC plus SEQ ID NO:843 LC), LTA PRASA A6 HC-L4E-L4-AB (Construct 19 in Table 1; SEQ ID NO:HC 925 plus SEQ ID NO:846 LC) and mAb 5133 PRASA A6 HC-L4-E-L4-AB (Construct 11 in Table 1; SEQ ID NO:856 HC plus SEQ ID NO:67 LC). All test articles were administered IP at a dose of 500 μg per animal 24-hours prior to infection. 
     Results. 
       FIG. 7  shows the reductions in kidney severity scores, the total kidney surface lesions per group and the viable bacterial burdens per individual kidneys recovered for each dosed animal. As expected, treatment with the isotype control anti-RSV antibody (CNTO3930, Lane 1 in  FIGS. 7A and 7B ) resulted in the highest mean bacterial burden in the kidneys with a mean log 10 CFU/g kidney of 8.2 ( FIG. 7A ) or 7.0 ( FIG. 7B ) and with visual evidence of lesions on each kidney harvested from the group of eight animals (16/16). Treatment with mAb 5133 PRASA A6 (Lane 2 in  FIGS. 7A and 7B ), reduced the bacterial burden in the kidney by minus 0.5-0.7 log 10 CFU/g compared to CNTO3930 and lowered kidney abscess lesion incidence to 87.5% (14/16). Treatment with mAb-FN3 fusion proteins which differ only in their V-region component but are otherwise identical in their anti-toxin FN3 components as fused to the heavy chain of the mAb entity resulted in efficacy enhanced over mAb 5133 PRASA A6 only in some specific cases. Specifically, treatment with mAb-FN3 fusion targeting staphylococcal antigens Protein-A (Lanes 3 &amp; 4 in  FIG. 7A ) or LTA (Lane 3 in  FIG. 7B ) resulted in minimal if any enhancement in efficacy as evidenced by kidney surface lesions per group and the viable bacterial burdens per individual kidneys recovered for each dosed animal. In contrast, mAb-FN3 fusion proteins targeting either IsdB (Lane 5 in  FIG. 7A ), the unknown surface antigen of mAb 6526 (Lane 6 in  FIG. 7A ) or glycosylated forms of the SDR family of adhesin proteins (Lane 8 in  FIG. 7A  and Lane 4 of  FIG. 7B ) exhibited efficacy significantly improved over the other mAb-FN3 fusion proteins and mAb 5133 PRASA A6. Of these, the mAb 5133-based mAb-FN3 fusion protein targeting the SDR family of adhesin proteins (mAb 5133 PRASA A6 HC-L4-E-L4-AB; Construct 11 in Table 1) was the most efficacious of all reducing the bacterial burden in the kidney by minus 1.9 to 2.5 log 10  CFU/g compared to CNTO3930 and reducing kidney lesion incidence by 50 to 62.5% (8/16 to 6/16). 
     Summary. 
     These data support show that the V-region target of mAb 5133 and mAb 5133-based FN3 fusion proteins affords efficacy improved over other anti-staphylococcal mAbs and mAb-FN3 fusion proteins targeting different  S. aureus  surface-expressed antigens including Protein-A, lipoteichoic acid, Iron Sulfur Determinant B (IsdB) and that targeted by mAb CR-6526. 
     Example 8: The Efficacy of mAb5133 and mAb 5133-FN3 Fusion Proteins is Enhanced in the Presence of Sub-Therapeutic Concentrations of Vancomycin in a Mouse Kidney Infection Model 
     Patients with serious, diagnosed  S. aureus  infections that may benefit clinically from administration of an anti-staphylococcal biologic agent will likely be receiving antibiotic therapy. Hence, it is of interest to understand whether the co-administration of an anti-staphylococcal biologic agent either interferes with antibiotic activity, has no impact, or possibly enhances antibiotic effectiveness. To address this, a series of biologic test articles were administered to mice in the context of sub-therapeutic doses of the commonly used, first-line anti-MRSA antibiotic, vancomycin, and efficacy assessed in a mouse renal (kidney) infection model of disease. As an isotype IgG1 control, non-antistaphylococcal antibody, CNTO3930 (SEQ ID NO: 104 HC plus SEQ ID NO: 105 LC) was employed that targets the respiratory syncytial virus F (RSV-F) protein. 
     Procedure. 
     Female 5-6 week old Swiss Webster ND4 mice (Harlan Laboratories, Indianapolis, Ind.) were administered test articles (8 per group) via intra-peritoneal (IP injection) 24 hours prior to infection. Mice were subsequently infected with a pre-determined fixed concentration (˜10{circumflex over ( )}6 Log 10 CFU per mouse) of  S. aureus  Newman (Baba et al., “Genome Sequence of  Staphylococcus aureus  Strain Newman and Comparative Analysis of Staphylococcal Genomes: Polymorphism and Evolution of Two Major Pathogenicity Islands,”  J. Bacteriol.  190(1):300-310 (2008), which is hereby incorporated by reference in its entirety), injected in a 100 μL volume retro-orbitally (under isoflurane anesthesia) using a 28 G, ½ inch needle. The administered concentration corresponds to the lowest bacterial inoculum that typically yields a robust kidney infection as defined by the resulting bacterial burden. Bacterial burden is reflected by determinations of colony forming units (CFUs) measured from homogenates of explanted kidneys and the visual observation and enumeration of kidney surface (abscess) lesions. In all cases, test articles were administered 24 hours prior to infection and mice euthanized and kidneys harvested 96 hour post infection. Kidneys were scored for severity of infection via visual lesion count. The kidneys were then explanted, weighed, homogenized, and the resulting homogenates serially diluted and plated on bacterial growth media (Tryptic Soy Agar (TSA)) to determine terminal viable bacterial burdens per individual kidneys via the CFU endpoint. Mice were monitored daily for health observations. Statistical analysis of both the lesion data and bacterial burden (CFU) data was performed by calculating p-values using the Dunn&#39;s Method. Test articles evaluated were CNTO3930 (Construct 21 in Table 1; SEQ ID NO:104 HC plus SEQ ID NO:105 LC), mAb 5133 PRASA (Construct 2 in Table 1; SEQ ID NO: 62 HC plus SEQ ID NO:63 LC), mAb 5133 PRASA A6 HC-L4-E (Construct 15 in Table 1; SEQ ID NO:848 plus SEQ ID NO:71 LC) and mAb 5133 PRASA A6 HC-L4-E-L4-AB (Construct 11 in Table 1; SEQ ID NO:856 HC plus SEQ ID NO:67 LC). All test articles were administered IP at a dose of 500 μg per animal 24-hours prior to infection. Where administered, vancomycin was dosed at 3.125 mgs/kg IP one and three hours post-infection. 
     Results. 
       FIG. 8  shows the reduction in total kidney surface lesions per group and the viable bacterial burdens per individual kidneys recovered for each dosed animal. As expected, treatment with the isotype control anti-RSV antibody (CNTO3930,  FIG. 8 , Lane 1) resulted in the highest mean bacterial burden in the kidneys with a mean log 10 CFU/g kidney of 7.0 and with visual evidence of lesions on each kidney harvested from the group of eight animals (16/16). Combination of a sub-therapeutic dose of vancomycin (3.125 mgs/kg one and three hours post-infection) with CNTO3930 resulted in enhanced efficacy with lesion score reduced to 75% (12/16) and mean bacterial burden reduced by minus 0.9 log 10 CFU/g kidney ( FIG. 8 , Lane 2). Treatment with mAb 5133 PRASA ( FIG. 8 , Lane 3) resulted in a reduction in bacterial burden in the kidneys with a mean log 10 CFU/g kidney of minus 1.3 compared to CNTO3930 and a reduction in kidney lesions to 37.5% (6/16) compared to CNTO3930. Combination of a sub-therapeutic dose of vancomycin (3.125 mgs/kg one and three hours post-infection) with mAb513 PRASA resulted in enhanced efficacy with lesion score reduced to 18.75% (3/16) and mean bacterial burden reduced by minus 1.8 or 2.7 log 10 CFU/g kidney ( FIG. 8 , Lane 4) compared to CNTO3930 and CNTO3930 plus vancomycin, respectively. Treatment with the mAb-FN3 fusion protein mAb 5133 PRASA A6 HC-L4-LukE protein ( FIG. 8 , Lane 5) resulted in a reduction in bacterial burden in the kidneys with a mean log 10 CFU/g kidney of minus 1.2 compared to CNTO3930 and a reduction in kidney lesions to 50% (8/16) compared to CNTO3930. Combination of a sub-therapeutic dose of vancomycin (3.125 mgs/kg one and three hours post-infection) with mAb 5133 PRASA A6 HC-L4-LukE resulted in further enhanced efficacy with no apparent kidney lesions (0/16) and mean bacterial burden reduced by minus 1.7 or 2.6 log 10 CFU/g kidney ( FIG. 8 , Lane 6) compared to CNTO3930 and CNTO3930 plus vancomycin, respectively. Treatment with the mAb-FN3 fusion protein mAb 5133 PRASA A6 HC-L4-LukE-L4-LukAB protein ( FIG. 8 , Lane 7) resulted in a reduction in bacterial burden in the kidneys with a mean log 10 CFU/g kidney of minus 1.6 compared to CNTO3930 and a reduction in kidney lesions to 12.5% (2/16) compared to CNTO3930. Finally, combination of a sub-therapeutic dose of vancomycin (3.125 mgs/kg one and three hours post-infection) with mAb 5133 PRASA A6 HC-L4-LukE-L4-LukAB resulted in further enhanced efficacy with no apparent kidney lesions (0/16) and mean bacterial burden reduced by minus 1.8 or 2.7 log 10 CFU/g kidney ( FIG. 8 , Lane 8) compared to CNTO3930 and CNTO3930 plus vancomycin, respectively. 
     Summary. 
     These data show that biologic agents that target glycosylated forms of the SDR family of adhesin proteins and neutralize leukotoxins LukAB and LukED may be used in combination with standard-of-care antibiotic agents like vancomycin to afford enhanced therapeutic benefit for patients diagnosed with serious  S. aureus  infections. 
     Example 9: Improved Efficacy of mAb 5133-FN3 Fusion Proteins Compared to mAb-5133 in a Mouse Bacteremia Model 
     In understanding the relative contributions of the V-region and/or the anti-leukotoxin FN3 components of mAb 5133-based FN3 fusion proteins with regard to efficacy in animal models of human  S. aureus  infections, a series of test articles were compared for their relative efficacy in a mouse model of bacteremia disease. Specifically, a series of test articles were evaluated “head-to-head” that bear the same mAb 5133-derived V-region (targeting glycosylated forms of the SDR family of adhesins) but differ in their FN3 domain composition. As an isotype IgG1 control, non-antistaphylococcal antibody, CNTO3930 (SEQ ID NO: 104 HC plus SEQ ID NO: 105 LC) was employed that targets the respiratory syncytial virus F (RSV-F) protein. 
     Procedure. 
     Female 5-6 week old Swiss Webster ND4 mice (Harlan Laboratories, Indianapolis, Ind.) were administered test articles (4-8 per group) via the retro-orbital (RO) route in a fixed dose volume of 100 μL/mouse 4 hours prior to infection. Mice were subsequently infected with a fixed concentration (1×10 5.4  Log 10  CFU per mouse) of  S. aureus  Newman injected in a 200 μL volume via the intra-peritoneal (IP) route using a 27 G, ½ inch needle. Two hours later, mice were euthanized by CO 2  asphyxiation and immediately bled by cardiac puncture into lithium heparin tubes and neat blood plus serial dilutions in phosphate buffered saline (PBS) immediately plated on Tryptic Soy Agar (TSA) plates. Then 2-5 mLs of sterile saline was injected via the intra-peritoneal (IP) route, gently mixed by inverting the mouse several times, and the peritoneal fluid collected by opening the peritoneum and withdrawing the fluid using a 1 cc syringe. After collecting the peritoneal fluid, the spleen was collected, weighed, and homogenized. Spleen homogenates and the peritoneal fluid were serially diluted with sterile saline and plated on bacterial growth media (TSA) to determine the terminal viable bacterial burdens in both peritoneal fluid and spleens. Statistical analysis was performed by unpaired t-test using GraphPad Prism, version 5.0. Test articles evaluated were CNTO3930 (Construct 21 in Table 1; SEQ ID NO:104 HC plus SEQ ID NO:105 LC), mAb 5133 PRASA A6 (Construct 4 in Table 1; SEQ ID NO:66 HC plus SEQ ID NO:67 LC), mAb 5133 PRASA A6 HC-L4-E-L1-AB (Construct 12 in Table 1; SEQ ID NO: 952 HC plus SEQ ID NO:67 LC), mAb 5133 PRASA A6 HC-L4-E-L1-AB-FLAG (Construct 13 in Table 1; SEQ ID NO:965 HC plus SEQ ID NO:63 LC), mAb 5133 PRASA A6 HC-L4-E-L4-AB-FLAG (Construct 14 in Table 1; SEQ ID NO:970 HC plus SEQ ID NO:63 LC) and mAb 5133 PRASA A6 HC-L4-E-L4-AB (Construct 11 in Table 1; SEQ ID NO:856 HC plus SEQ ID NO:67 LC). All test articles were administered RO at a dose of 500 μg per animal. 
     Results. 
       FIG. 9  shows the reduction in viable bacterial burden in the blood and spleen per individual animal. As expected, treatment with the isotype control anti-RSV antibody (CNTO3930,  FIG. 9 , Lane 1) resulted in the highest mean bacterial burden in both the blood ( FIG. 9 , top panel) and spleen ( FIG. 9 , bottom panel). Treatment with mAb 5133 PRASA A6 ( FIG. 9 , Lane 2), reduced the bacterial burden in both the blood and spleen, but this reduction was not significant relative to CNTO3930 treatment with calculated p values of 0.23 and 0.08 for blood and spleen, respectively. In contrast, treatment with all mAb 5133-based FN3 fusion proteins targeting LukE and LukAB ( FIG. 9 , Lanes 3, 4, 5 and 6) resulted in reductions in bacterial burden in both the blood (top panel) and spleen (bottom panel) compared to CNTO3930 with calculated p values in the 0.006 to 0.0001 range. 
     Summary. 
     These data show that mAb 5133-FN3 fusion proteins that target glycosylated forms of the SDR family of adhesin proteins and neutralize leukotoxins LukAB and LukED may have therapeutic utility in the treatment of  S. aureus  mediated bacteremia. 
     Example 10: Improved Efficacy of mAb 5133-FN3 Fusion Proteins Compared to the Sum of its Composite Parts 
     In understanding the relative contributions of the V-region and/or the anti-toxin FN3 components of mAb 5133-based FN3 fusion proteins with regard to efficacy in animal models of human  S. aureus  infections, a series of test articles were compared for their relative efficacy in a mouse renal (kidney) infection model of disease. Specifically, a series of test articles were evaluated “head-to-head” that bear the same mAb 5133-derived V-region (targeting glycosylated forms of the SDR family of adhesins) but differ in their FN3 domain composition. As an isotype IgG1 control, non-antistaphylococcal antibody, CNTO3930 (SEQ ID NO: 104 HC plus SEQ ID NO: 105 LC) was employed that targets the respiratory syncytial virus F (RSV-F) protein. 
     Procedure. 
     Female 5-6 week old Swiss Webster ND4 mice (Harlan Laboratories, Indianapolis, Ind.) were administered test articles (8 per group) via intra-peritoneal (IP) injection in a fixed dose volume of 200 μL/mouse 24 hours prior to infection. Mice were subsequently infected with a pre-determined fixed concentration (˜6.8×10{circumflex over ( )}6 Log 10  CFU per mouse) of  S. aureus  Newman (Baba et al., “Genome Sequence of  Staphylococcus aureus  Strain Newman and Comparative Analysis of Staphylococcal Genomes: Polymorphism and Evolution of Two Major Pathogenicity Islands,”  J. Bacteriol.  190(1):300-310 (2008), which is hereby incorporated by reference in its entirety) injected in a 100 μL volume retro-orbitally (under isoflurane anesthesia) using a 28 G, ½ inch needle. This infectious dose corresponds to the lowest bacterial inoculum that typically yields a robust kidney infection as defined by the resulting bacterial burden. In all cases, test articles were administered 24 hours prior to infection and mice euthanized and kidneys harvested 96 hour post infection. Mice were monitored daily for health observations. Kidneys were scored for severity of infection via visual lesion (abscess) count with the aid of a dissecting microscope, and then explanted, weighed, homogenized, and the resulting homogenates serially diluted and plated on bacterial growth media (Tryptic Soy Agar (TSA)) to determine terminal viable bacterial burdens per individual kidney via the CFU endpoint. The kidney severity abscess score was recorded as: 1-2 visible lesions=severity score 1, 3-9 visible lesions=severity score 2, and &gt;=10 visible lesions=severity score 3. Mice were monitored daily for health observations. Statistical analysis of both the lesion data and bacterial burden (CFU) data was performed by calculating p-values using the Dunn&#39;s Method. Test articles evaluated were CNTO3930 (Construct 21 in Table 1; SEQ ID NO:104 HC plus SEQ ID NO:105 LC), mAb 5133 PRASA A6 (Construct 4 in Table 1; SEQ ID NO:66 HC plus SEQ ID NO:67 LC), mAb 5133 PRASA A6 HC-L4-AB (Construct 6 in Table 1; SEQ ID NO:70 HC plus SEQ ID NO:71 LC), mAb 5133 PRASA A6 HC-L4-E (Construct 15 in Table 1; SEQ ID NO: 848 HC plus SEQ ID NO:71 LC) and mAb 5133 PRASA A6 HC-L4-E-L4-AB (Construct 11 in Table 1; SEQ ID NO:856 HC plus SEQ ID NO:67 LC). All test articles were administered IP at a dose of 250 μg per animal, alone or in combination, 24 hours prior to infection. 
     Results. 
       FIG. 10  shows the reductions in kidney severity scores, the total visible kidney surface lesions per group and the viable bacterial burdens per individual kidney recovered for each dosed animal. As expected, treatment with the isotype control anti-RSV antibody (CNTO3930,  FIG. 10 , Lane 1) resulted in the highest mean bacterial burden in the kidneys with a mean log 10 CFU/g kidney of 6.9 and with the highest visual evidence of lesions on each kidney harvested from the group of eight animals (16/16). Treatment with mAb 5133 PRASA A6 ( FIG. 10 , Lane 2), reduced the bacterial burden in the kidney by minus 0.2 log 10 CFU/g compared to CNTO3930 and lowered kidney lesion incidence to 87.5% (14/16). Treatment with mAb 5133 PRASA A6 HC-L4-AB ( FIG. 10 , Lane 3) reduced the bacterial burden in the kidney by minus 0.2 log 10  CFU/g compared to CNTO3930 and lowered the kidney lesion incidence further to 62.5% (10/16). Treatment with mAb 5133 PRASA A6 HC-L4-E ( FIG. 10 , Lane 4) reduced the bacterial burden in the kidney by minus 1.3 log 10  CFU/g compared to CNTO3930 and lowered the kidney lesion incidence further to 56.25% (9/16). Combination of mAb 5133 PRASA A6 HC-L4-AB with mAb 5133 PRASA A6 HC-L4-E ( FIG. 10 , Lane 5), each dosed at 250 μg/animal (500 μg total per animal), further reduced the bacterial burden in the kidney by minus 1.7 log 10  CFU/g compared to CNTO3930 and lowered the kidney lesion incidence further to 50% (8/16). However, treatment with mAb 5133 PRASA A6 HC-L4-E-L4-AB (Lane 6) afforded maximal efficacy dosed at 250 μg/animal with the bacterial burden in the kidney reduced by minus 2.6 log 10  CFU/g compared to CNTO3930 and lowering of the kidney lesion incidence to 37.5% (6/16). 
     Summary. 
     These data show that mAb 5133-FN3 fusion proteins bearing a tandem appendage of FN3 domains targeting both the leukotoxins ED and AB confer efficacy in this mouse model of kidney infection that is enhanced over mAb 5133-FN3 fusion proteins individually targeting leukotoxins ED and AB. Further, the efficacy of mAb 5133 PRASA A6 HC-L4-E-L4-AB dosed at 250 μg/animal is enhanced over the efficacy of mAb 5133 PRASA A6 HC-L4-AB dosed in combination with mAb 5133 PRASA A6 HC-L4-E (each dosed at 250 μg/animal) in support of the notion that the efficacy of mAb 5133 PRASA A6 HC-L4-E-L4-AB is improved over the sum of its composite parts (mAb 5133 PRASA A6 HC-L4-AB and mAb 5133 PRASA A6 HC-L4-E). 
     Example 11: Improved Efficacy of mAb 5133-FN3 Fusion Proteins Compared to mAb5133 in a Mouse Skin Infection Model 
     In understanding the relative contributions of the V-region and/or the anti-toxin FN3 components of mAb 5133-based FN3 fusion proteins with regard to efficacy in animal models of human  S. aureus  infections, a series of test articles were compared for their relative efficacy in a mouse model of skin infection. Specifically, a series of test articles were evaluated “head-to-head” that bear the same mAb 5133-derived V-region (targeting glycosylated forms of the SDR family of adhesins) but differ in their FN3 domain composition. As an isotype IgG1 control, non-antistaphylococcal antibody, CNTO3930 (SEQ ID NO: 104 HC plus SEQ ID NO: 105 LC) was employed that targets the respiratory syncytial virus F (RSV-F) protein. 
     Procedure. 
     These studies employed SKH-1 Elite mice (Charles River Laboratories, Wilmington, Mass.) which are an outbred hairless, immunocompetent strain. Female 8-10 weeks old mice were administered test articles (8 per group) via intra-peritoneal (IP) injection in a fixed dose volume of 200 μL/mouse 4 hours before or after infection. Mice were subsequently infected under isoflurane anesthesia with a pre-determined fixed concentration (˜6.6×10 6  Log 10 CFU per mouse) of  S. aureus  MRSA strain JE2 (Fey et al., “A Genetic Resource for Rapid and Comprehensive Phenotype Screening of Nonessential  Staphylococcus aureus  Genes,”  mBio  4(1):e00537-12 (2013), which is hereby incorporated by reference in its entirety) as a 0.1% suspension of dextrin microcarrier beads (Cytodex 1®, Sigma-Aldrich Chemical Company, St. Louis, Mo.) in a 200 μL volume by subcutaneous (SC) injection with a 27 G, ½ inch needle. Three days after infection, animals were euthanized by CO 2  asphyxiation. Skin lesions were measured (length and width) by electronic digital caliper (Mitutoyo Corporation, Aurora, Ill.) and the corresponding skin was aseptically collected, serially diluted in sterile saline, and plated on TSA plates to determine bacterial burden. A lesion volume score was calculated from the following equation: LV=(π/6)(L×W2), where LV=lesion volume, L=length of the lesion in mm, and W=width of the lesion in mm (Bunce et al.,  Infect and Immunity,  60:2636-2640 (1992), which is hereby incorporated by reference in its entirety). Statistical analysis performed by unpaired t-test using GraphPad Prism, version 5.0. Test articles evaluated were CNTO3930 (Construct 21 in Table 1; SEQ ID NO: 104 HC plus SEQ ID NO: 105 LC), mAb 5133 PRASA A6 (Construct 4 in Table 1; SEQ ID NO:66 HC plus SEQ ID NO:67 LC), mAb 5133 PRASA A6 HC-L4-E-L1-AB (Construct 12 in Table 1; SEQ ID NO:952 HC plus SEQ ID NO:67 LC) and mAb 5133 PRASA A6 HC-L4-E-L4-AB (Construct 11 in Table 1; SEQ ID NO:856 HC plus SEQ ID NO:67 LC). All test articles were administered IP at a dose of 500 μg per animal. 
     Results. 
       FIG. 11  shows the efficacy of the evaluated test articles in this mouse model of human  S. aureus  skin infections as assessed by skin lesion volume ( FIG. 11A ) or bacterial burden in skin lesions ( FIG. 11B ) when dose either 4 hours prior to or 4 hours after infection. As expected, treatment with the isotype control anti-RSV antibody (CNTO3930, Lane 1) resulted in the largest mean skin lesion volumes ( FIG. 11A ) and highest bacterial burden in skin lesions ( FIG. 11B ) corresponding to 6.0 to 6.2×log 10  CFU/g of skin. Treatment with mAb 5133 PRASA A6 (Lane 2), significantly reduced the mean skin lesion volume compared to CNTO3930 with a calculated p values of 0.004 to 0.005 ( FIG. 11A , lanes 3 and 4) but while the bacterial burden in skin lesions ( FIG. 11B , lanes 3 and 4) was reduced by minus 0.8 and 0.1 log 10  CFU/g when dosed pre- and post-infection, respectively, the efficacy observed was not considered statistically significant when compared to the efficacy observed with CNTO3930 (p values 0.26 and 0.96). In contrast, treatment with both mAb5133-based FN3 fusion proteins resulted in statistically significant reductions in both skin lesion volumes ( FIG. 11A ) and bacterial burden in skin lesions ( FIG. 11B ) compared to CNTO3930 when dosed either 4 hour pre- or 4 hours post-infection with calculated p values in the range 0.003 to 0.0001. 
     Summary. 
     These data indicate that mAb 5133-FN3 fusion proteins that target glycosylated forms of the SDR family of adhesin proteins and neutralize leukotoxins LukAB and LukED in exposed skin tissue, indicating therapeutic utility in the treatment of  S. aureus  mediated skin infections. 
     Example 12: mAb5133-FN3 Fusion Proteins Provide Improved Protection from Staphylococcal Mediated Extracellular Killing of Primary Human Neutrophils 
     Leukotoxins are capable of killing key classes of human immune cells, including neutrophils both from the outside of the cell via a process triggered by engagement with specific receptors on the immune cell surface and are also capable of killing from the inside of the cell through leukotoxin-mediated escape from the phagolysosome (Alonzo and Torres, “The Bicomponent Pore-forming Leucocidins of  Staphylococcus aureus,” Microbiol Mol Biol Rev.  78(2):199-230 (2014), which is hereby incorporated by reference in its entirety). The studies described herein exemplify the ability of mAb5133-FN3 fusion proteins that bind and neutralize leukotoxins LukED and LukAB to afford protection of primary human neutrophils from extracellular killing mediated by a  S. aureus  USA 300 CA-MRSA strain BK18807 (Kennedy et al., “Epidemic Community-associated Methicillin-resistant  Staphylococcus aureus : Recent Clonal Expansion and Diversification,”  Proc. Natl. Acad. Sci. U.S.A  105:1327-1332 (2008), which is hereby incorporated by reference in its entirety). As an isotype IgG1 control, non-antistaphylococcal antibody, CNTO3930 (SEQ ID No: 104 HC plus SEQ DI NO: 105 LC) was employed that targets the respiratory syncytial virus F (RSV-F) protein 
     Procedure. 
       S. aureus  BK18807 was grown overnight in RPMI+CAS medium and then sub-cultured 1:100 in RPMI+CAS and grown for a further 5 hours. The culture was thereafter normalized to 1×10 9  CFU/mL with RPMI+CAS. The bacterial suspension (85 μL) (˜8.5×10 7  CFU) was then mixed with 180 μL of a 2.5 mg/mL stock concentration of each test article (450 μg each) and 455 μL of RPMI+10 mM HEPES added to yield a final volume of 720 μL. 96-well plates were coated with 20% human serum for 20 mins at 37 C.°+5% CO 2  and then washed twice with RPMI plus 10 mM HEPES and 0.1% HSA (RPMI-HH). 80 μl of a freshly purified human primary polymorphonuclear leukocytes (PMNs) were then added to each test well corresponding to ˜250,000 cells per well and the plate incubated at room temperature (RT) for 30 mins. 20 μl of the opsonized suspension of bacteria were then added to each PMN containing well to yield a multiplicity of infection (MOI) of ˜10, and the plate incubated for 120 mins at 37 C ° in 5% CO 2 . Plates were then centrifuged for 5 mins at 1,500 RPM. For assessment of cytolysis by lactate dehydrogenase (LDH) release, 25 μL of the supernatants from each test well were transferred into a new black, clear bottom 96-well plate. 25 μL of CytoTox-ONE™ Assay reagent (Promega) was added and the plate incubated in the dark for 15 mins. CytoTox-ONE™ Assay reagent measures the release of LDH from cells with a damaged membrane via a coupled enzymatic assay that results in the conversion of resazurin into a fluorescent resorufin product detected via plate reading in a spectrometer. These experiments were performed with purified human primary polymorphonuclear leukocytes (PMNs) from six independent donors. Test articles evaluated were CNTO3930 (Construct 21 in Table 1; SEQ ID NO: 104 HC plus SEQ ID NO: 105 LC), mAb 5133 PRASA A6 (Construct 4 in Table 1; SEQ ID NO: 66 HC plus SEQ ID NO: 67 LC), mAb 5133 PRASA A6 HC-L4-E-L4-AB (Construct 11 in Table 1; SEQ ID NO: 856 HC plus SEQ ID NO: 67 LC), mAb 5133 PRASA A6 HC-L4-E-L4-AB-FLAG (Construct 24 in Table 1; SEQ ID NO: 918 HC plus SEQ ID NO: 67 LC), c-Myc-mAb 5133 PRASA A6 HC-L4-E-L4-AB (Construct 25 in Table 1; SEQ ID NO: 919 HC plus SEQ ID NO: 67 LC) and c-Myc-mAb 5133 PRASA A6 HC-L4-E-L4-AB-FLAG (Construct 26 in Table 1; SEQ ID NO: 920 HC plus SEQ ID NO: 67 LC). 
     Results. 
       FIG. 12  shows the relative impact of pre-incubation of the test articles with  S. aureus  BK18807 in protecting primary human neutrophils from cytolysis as determined by release of LDH. As expected, CNTO3930 (Lane 1) afforded the least protection as it bears a V-region specific for the RSV-F protein and has no appended FN3 domains capable of binding and neutralizing the cytolytic leukotoxins. Similarly, mAb 5133 (Lane 2) afforded minimal PMN protection indicating that V-region surface engagement of the glycosylated forms of SDR proteins is not significantly protective in this assay. In contrast, all of the four tested mAb5133-FN3 fusion proteins that bear FN3 domains that bind and neutralize LukED and LukAB exhibit maximal PMN protection (Lanes 3 to 6). 
     Summary. 
     These data indicate that mAb 5133-FN3 fusion proteins that bind and neutralize the cytolytic activity of leukotoxins LukAB and LukED are capable of protecting human primary neutrophils from leukotoxin-mediated killing. This activity of mAb 5133-FN3 fusion protein targeting LukED and/or LukAB may be of therapeutic utility in the context of  S. aureus  mediated human infections. 
     Example 13: mAb5133-FN3 Fusion Proteins Provide Improved Protection from Staphylococcal Mediated Intracellular Killing of Primary Human Neutrophils 
     Leukotoxins are capable of killing key classes of human immune cells, including neutrophils both from the outside of the cell via a process triggered by engagement with specific receptors on the immune cell surface and are also capable of killing from the inside of the cell through leukotoxin-mediated escape from the phagolysosome (Alonzo and Torres, “The Bicomponent Pore-forming Leucocidins of  Staphylococcus aureus,” Microbiol Mol Biol Rev.  78(2):199-230 (2014), which is hereby incorporated by reference in its entirety). The studies described herein exemplify the ability of mAb5133-FN3 fusion proteins that bind and neutralize leukotoxins LukED and LukAB to afford protection to primary human neutrophils from intracellular killing mediated by  S. aureus  USA 300 MRSA strain LAC (Chambers, H. F., “Community-associated MRSA-resistance and Virulence Converge,”  N. Engl. J. Med.  352:1485-1487 (2005), which is hereby incorporated by reference in its entirety). As an isotype IgG1 control, non-antistaphylococcal antibody, CNTO3930 (SEQ ID NO: 104 HC plus SEQ ID NO: 105 LC) was employed that targets the respiratory syncytial virus F (RSV-F) protein. 
     Procedure. 
       S. aureus  LAC and a variant deleted for the lukAB genes (LAC ALukAB) were grown overnight in RPMI+CAS medium and then sub-cultured 1:100 in RPMI+CAS and grown for a further 5 hours. The cultures were thereafter normalized to 1×10 9  CFU/mL with phosphate buffered saline (PBS) and further diluted in PBS in accord with the target multiplicity of infection (MOI). 96-well plates were coated with 20% human serum at 37° C. in 5% CO 2  and then washed twice with RPMI+10 mM HEPES. Freshly purified human primary polymorphonuclear leukocytes (PMNs) were re-suspended in RPMI plus 10 mM HEPES and 0.1% HSA (RPMI-HH), was added to each test well corresponding to ˜250,000 per well. The plate was incubated at room temperature (RT) for 30 mins. Leukotoxin containing supernatants were prepared as a filtrate of culture supernatant from cultures of  S. aureus  LAC WT and AlukAB grown for 5 hours at 37° C. in RPMI+CAS following a 1:100 dilution of an overnight culture. Opsonization of  S. aureus  LAC was initiated by combining bacteria at a target MOI of 1.0 (5×10 6  CFU/mL in 23.6 μL), 47.25 μL of filtered  S. aureus  LAC culture supernatant (as an exogenous source of leukotoxins), 945 μL of 2.5 mg/mL stocks of test article plus 3709.15 mL of RPMI plus 10 mM HEPES to yield a final volume of 4725 μL. Per well, 50 μL of the opsonized bacteria mixture was combined with 50 μL of the fresh PMN suspension and synchronization effected by centrifuging the plates for 1,500 RPM for 7 minutes. Plates were incubated for 120 minutes at 37° C. in 5% CO 2 . Following incubation, plates were then spun at 1,400 RPM for 7 minutes. For assessment of cytolysis by lactate dehydrogenase (LDH) release, 25 μL of the supernatants from each test well were transferred into a new black, clear bottom 96-well plate. 25 μL of CytoTox-ONE™ Assay reagent (Promega) was added and the plate was incubated in the dark for 15 mins. CytoTox-ONE™ Assay reagent measures the release of LDH from cells with a damaged membrane via a coupled enzymatic assay that results in the conversion of resazurin into a fluorescent resorufin product detected via plate reading in a spectrometer. These experiments were performed with purified human primary polymorphonuclear leukocytes (PMNs) from six independent donors. Test articles evaluated were CNTO3930 (Construct 21 in Table 1; SEQ ID NO: 104 HC plus SEQ ID NO: 105 LC), mAb 5133 PRASA A6 (Construct 4 in Table 1; SEQ ID NO: 66 HC plus SEQ ID NO: 67 LC) and mAb 5133 PRASA A6 HC-L4-E-L4-AB (Construct 11 in Table 1; SEQ ID NO: 856 HC plus SEQ ID NO: 67 LC). 
     Results. 
       FIG. 13  shows the relative activity of the test articles in protecting primary human neutrophils from cytolysis mediated by  S. aureus  LAC and LACALukAB strains as determined by release of LDH. As expected, CNTO3930 (Lane 2) afforded the least protection from  S. aureus  LAC mediated killing compared to the buffer-alone control (Lane 1) as it bears a V-region specific for the RSV-F protein and has no appended FN3 domain capable of binding and neutralizing the cytolytic leukotoxins. However, note that genetic inactivation of the LukAB leukotoxin eliminates PMN killing in this assay (Lanes 1 to 4). Similarly, mAB 5133 PRASA A6 (Lane 3) afforded little protection indicating that V-region surface engagement of the glycosylated forms of SDR proteins is not a protective mechanism in this intracellular killing assay. In contrast, mAb 5133 PRASA A6 HC-L4-E-L4-AB (Lane 4) afforded complete protection from  S. aureus  LAC mediated killing with an overall reduction equivalent to that seen with the  S. aureus  LACALukAB strain. 
     Summary. 
     These data indicate that mAb 5133-FN3 fusion proteins that bind and neutralize the cytolytic activity of leukotoxins LukAB are capable of protecting human primary neutrophils from leukotoxin-mediated killing following engulfment into the intracellular environment. This activity of mAb 5133-FN3 fusion protein targeting LukAB may be of therapeutic utility in the context of  S. aureus  mediated human infections. 
     Example 14: mAb5133-FN3 Fusion Proteins Improve Opsonophagocytotic Killing of  Staphylococcus aureus  by Primary Human Neutrophils 
     Key classes of human immune cells including neutrophils kill  S. aureus  through opsonophagocytosis, a process where bacteria are engulfed into phagolysosome bodies and killed through the action of lytic and digestive enzymes. In counteracting this,  S. aureus  senses the acidic pH and the content of the phagolysosome environment, up-regulates the expression of key virulence determinants including leukotoxin AB, and kills the phagocyte from within following LukAB-mediated escape from the phagolysosome (Alonzo and Torres, “The Bicomponent Pore-forming Leucocidins of  Staphylococcus aureus,” Microbiol Mol Biol Rev.  78(2): 199-230 (2014), which is hereby incorporated by reference in its entirety). The studies described herein exemplify the ability of mAb5133-FN3 fusion proteins that bind and neutralize leukotoxins LukED and LukAB to enhance opsonophagocytotic killing by primary human neutrophils. As a negative control, RSV PRASA A6 HC-L4-wtTENCON fusion protein (Construct 27 in Table 1; SEQ ID NO: 977 HC plus SEQ ID NO: 843 LC) was used. This construct targets the respiratory syncytial virus F (RSV-F) protein via its V-region and bears a parental (wild-type consensus) FN3 domain that exhibits no leukotoxin binding or neutralization activities. 
     Procedure. 
     These studies employed a variety of MRSA of the USA300 lineage (LAC, FPR, 18807, 18808 and 18809), a USA500 lineage strain (BK2395), and a MSSA strain (BK4645b).  S. aureus  strains were grown overnight in RPMI+CAS medium and then sub-cultured 1:100 in RPMI+CAS and grown for a further 5 hours. The cultures were thereafter normalized to 1×10 9  CFU/mL with RPMI+CAS. Leukotoxin containing supernatants were prepared as filtrates of culture supernatants from cultures of  S. aureus  μgrown for 5 hours at 37° C. in RPMI+CAS following a 1:100 dilution of an overnight culture. To effect opsonization, pre-determined aliquots of bacteria necessary to achieve the desired MOI were combined with test articles plus or minus the addition of culture supernatant (11 μL) and RPMI-HEPES added to bring the volume to 440 μL (with each test article at a final concentration of 1.25 mg/mL). 96-well plates were coated with 20% human serum at 37° C. in 5% CO 2  and then washed twice with RPMI plus 10 mM HEPES and 0.1% HSA (RPMI-HH). A fresh preparation of purified human primary polymorphonuclear leukocytes (PMNs), re-suspended in RPMI plus 10 mM HEPES and 0.1% HSA (RPMI-HH) was added to each test well corresponding to ˜250,000 per well. The plate was incubated at room temperature (RT) for 30 mins. 20 μL of the opsonized  S. aureus  mixture was added per well and synchronization effected by centrifuging the plates for 1,500 RPM for 7 minutes. Plates were incubated for 120 minutes at 37° C. in 5% CO 2 . Following incubation, 11 μL of 1% saponin was added to each well and the plate incubated on ice for 20 mins. Thereafter, an aliquot from each well was serially diluted in phosphate buffered saline and aliquots plated on TSA plates to determine the remaining viable  S. aureus  cells through determination of colony forming units (CFUs). These experiments were performed with purified human primary polymorphonuclear leukocytes (PMNs) from six independent donors. Test articles evaluated were RSV PRASA A6 HC-L4-wtTENCON (Construct 27 in Table 1; SEQ ID NO: 977 HC plus SEQ ID NO: 843 LC), mAb 5133 PRASA A6 (Construct 4 in Table 1; SEQ ID NO: 66 HC plus SEQ ID NO: 67 LC), mAb 5133 PRASA A6 HC-L4-E (Construct 15 in Table 1; SEQ ID NO: 848 HC plus SEQ ID NO: 71 LC), mAb 5133 PRASA A6 HC-L4-E-L4-AB (Construct 28 in Table 1; SEQ ID NO: 858 HC plus SEQ ID NO: 67 LC) and mAb 5133 PRASA A6 HC-L4-E-L4-AB (Construct 11 in Table 1; SEQ ID NO: 856 HC plus SEQ ID NO: 67 LC). 
     Results. 
       FIGS. 14A-14D  shows the relative activity of the different test articles in enhancing opsonophagocytotic killing of a number of different  S. aureus  strains by primary human neutrophils. In  FIG. 14A , data is shown for an opsonophagocytotic killing (OPK) assay undertaken with the MRSA LAC strain at a MOI of 1+/−0.5% LAC culture supernatant (as an exogenous source secreted leukotoxins). As expected, RSV PRASA A6 HC-L4-wtTENCON (Lanes 1 and 6 in  FIG. 14A ) afforded the least protection from opsonophagocytotic killing of the CA-MRSA LAC strain as it bears a V-region specific for the RSV-F protein and has no appended FN3 domain capable of binding and neutralizing the cytolytic leukotoxins. In contrast, mAB 5133 PRASA A6 (Lane 2 in  FIG. 14A ) afforded marked OPK enhancement in the absence of adding culture supernatant indicating that V-region surface engagement of the glycosylated forms of SDR proteins is protective. However, this protection is eliminated when the assay is performed in the presence of culture supernatant (Lane 7 in  FIG. 14A ). In contrast, a series of mAb5133-FN3 fusion proteins that bind and neutralize the cytolytic activity of LukAB and/or LukED exhibited enhanced opsonophagocytotic killing in the presence or absence of culture supernatant (Lanes 3-5 and 8-10 in  FIG. 14A ) with the best overall protection observed with mAb5133-FN3 fusion proteins that bind and neutralize the cytolytic activity of both LukAB and LukED. Similar observations are seen in OPK assays employing a variety of  S. aureus  strains including additional USA300 lineage MRSA strains FPR, 18807, 18808 and 18809 ( FIG. 14B ), a MSSA strain BK4645b ( FIG. 14C ) an a USA500 lineage MRSA strain BK2395 ( FIG. 14D ). 
     Summary. 
     These data indicate that mAb 5133-FN3 fusion proteins that bind and neutralize the cytolytic activity of both leukotoxins LukED and LukAB afford the best enhancement of opsonophagocytotic killing mediated by human neutrophils. This activity of mAb 5133-FN3 fusion protein targeting both leukotoxins LukED and LukAB may be of therapeutic utility in the context of  S. aureus  mediated human infections. 
     Example 15: Identification and Characterization of Monoclonal Antibodies Targeting  S. aureus  Protein-A 
       S. aureus  protein A (SpA) is a key immune evasion factor which is either expressed and assembled on the cell surface or is secreted by the bacteria. Protein A binds the Fc (Fragment, crystallizable) domain of immunoglobulins as well as the fragment antigen-binding (Fab) domains of VH3 class IgGs and IgM (Forsgren A., “Protein A from  Staphylococcus aureus  VI. Reaction with Subunits from Guinea Pig γ1- and γ2-globulin”,  J. Immunol.  100: 927-30 (1968); Silverman G. J. and Goodyear, C. S., “Confounding B-cell Defences: Lessons from a Staphylococcal Superantigen”,  Nat. Rev. Immunol.  6: 465-75 (2006), which are hereby incorporated by reference in their entirety). This Fc binding activity of Protein A enables  S. aureus  to escape opsonophagocytic killing, whereas crosslinking of VH3-type IgM B cell receptors disrupts the development of adaptive immune responses (Falugi F., et al. “The Role of Protein A in the Evasion of Host Adaptive Immune Responses by  Staphylococcus aureus”, mBio  4: e00575-613 (2013), which is hereby incorporated by reference in its entirety). In exploring the relative contribution(s) of Fc-mediated binding by Protein A in limiting opsonophagocytic killing mediated by antibodies that target other cell surface localized  S. aureus  antigens, a series of monoclonal antibodies were identified that bind Protein A specifically via their Fab domains and these were subsequently engineered to remove Protein A binding mediated by Fc interactions. 
     Procedure. 
     Fab domains with high affinity for recombinant Protein A (ProSpec-TanyTechnoGene Ltd.) were identified via phage display and converted to human IgG1 mAbs. In the screening process, VH3 class Fabs were de-selected by selective restriction digestion. Three Protein A specific mAbs were selected for further characterization: ProA3 (SEQ ID NO: 1001 HC plus SEQ ID NO: 841 LC), SM1F5 (SEQ ID NO: 1007 HC plus SEQ ID NO: 1016 LC) and SM1F9 (SEQ ID NO: 1012 HC plus SEQ ID NO: 842 LC) and these were subsequently engineered to exhibit GluV8 protease resistance via introduction of the PRASA hinge region mutations (see Table 1) and/or Protein A binding via their Fc region via introduction of the A6 mutations (see Table 1). Characterization of Protein A binding was determined by ELISA. Briefly, plates were coated with streptavidin (5 μg/mL in PBS, 50 μL per well) and incubated overnight at 4° C. Plates were washed three times with ELISA wash buffer (0.15M NaCl, 0.02% Tween-20) and then coated with biotinylated Protein A at 2 μg/mL (50 L per well) in PBS for one hour at room temperature. Plates were then washed three times with ELISA wash buffer and then blocked with ELISA blocking buffer (3% BSA in PBS, 200 μL per well). Test articles were then added in a 3-fold dilution series starting at 10 μg/mL and the plates incubated at room temperature for one hour. Plates were then washed three times with ELISA wash buffer and 50 mL per well of HRP-conjugated goat anti-human kappa light chain (Millipore AP502P) added at a 1:15,000 dilution in 3% BSA in PBS and the plates incubated for one hour at room temperature. Plates were then washed five times with ELISA wash buffer and bound HRP detected using the 3,3′,5,5′-Tetramethylbenzidine (TMB; Fitzgerald) as a chromogenic substrate. Test Articles used were ProA3 PRASA A6 (Construct 29 in Table 1), ProA3 IgG1 (Construct 30 in Table 1), ProA3 PRASA (Construct 31 in Table 1), anti-LTA (Pagibaximab) IgG1 (Construct 32 in Table 1) and anti-LTA (Pagibaximab) PRASA A6 (Construct 33 in Table 1). 
     Results. 
     The binding of a monoclonal antibody to Protein A solely via Fc interaction is exemplified in  FIG. 15  by comparison of the ELISA binding curves for IgG1 wild-type pagibaximab and an engineered PRASA A6 variant that both target lipoteichoic acid via their Fab domains. As expected, no detectable binding to Protein A is observed in the case of the PRASA A6 variant. By way of example, the enhanced binding of monoclonal antibodies that target Protein A via their Fab domains is exemplified in  FIG. 15  in studies of a series of ProA3 related test articles. For these molecules, equivalent binding is observed for the IgG1 and PRASA variants with apparent tighter binding to plate-immobilized Protein A observed for the PRASA A6 variant. 
     Summary. 
     While the reasons underlying the apparent higher binding affinity for plate-immobilized Protein A exhibited by the PRASA A6 variant of the anti-Protein A antibody ProA3 are unclear, these data exemplify the identification of IgG antibodies capable of binding  S. aureus  protein A via the Fab region that is distinct from normal Fc-mediated interactions. 
     Example 16: mAb5133-FN3 Fusion Proteins Provide Improved Protection from LukAB-Dependent Extracellular Killing of Primary Human Neutrophils 
     Leukotoxins are capable of killing key classes of human immune cells, including neutrophils both from the outside of the cell via a process triggered by engagement with specific receptors on the immune cell surface and are also capable of killing from the inside of the cell through leukotoxin-mediated escape from the phagolysosome (Alonzo and Torres, “The bicomponent pore-forming leucocidins of  Staphylococcus aureus,” Microbiol. Mol. Biol. Rev.  78(2):199-230 (2014), which is hereby incorporated by reference in its entirety). The studies described herein exemplify the ability of mAb5133-FN3 fusion proteins that bind and neutralize leukotoxins LukED and LukAB to afford protection of primary human neutrophils from extracellular killing mediated by a number of  S. aureus  strains and the dependence of this phenomenon on the expression of LukAB. These studies employed otherwise-isogenic pairs of strains that either produce LukAB or fail to do so due to an engineered deletion of the lukAB operon; specifically (i)  S. aureus  strain Newman (Baba et al., “Genome Sequence of  Staphylococcus aureus  Strain Newman and Comparative Analysis of Staphylococcal Genomes: Polymorphism and Evolution of Two Major Pathogenicity Islands,”  J. Bacteriol.  190(1):300-310 (2008), which is hereby incorporated by reference in its entirety) labeled ‘Newman-WT’ and a lukAB deletion derivative thereof (‘Newman−ΔAB’), (ii)  S. aureus  USA 300 MRSA strain LAC (Chambers, H. F., “Community-associated MRSA-resistance and virulence converge,”  N. Engl. J. Med.  352:1485-1487 (2005), which is hereby incorporated by reference in its entirety) labeled ‘LAC-WT’ and a lukAB deletion derivative thereof (‘LAC-ΔAB’), (iii)  S. aureus  USA 300 MRSA strain BK18807, a 2005 isolate from a bacteremia patient (Kennedy et al., “Epidemic community-associated methicillin-resistant  Staphylococcus aureus : recent clonal expansion and diversification,”  Proc. Natl. Acad. Sci. U.S.A  105:1327-1332 (2008), which is hereby incorporated by reference in its entirety) labeled ‘18807-WT’ and a lukAB deletion derivative thereof (‘18807-ΔAB’), (iv)  S. aureus  USA 300 MRSA strain BK18808, a 2005 isolate from a patient with endocarditis (Kennedy et al., “Epidemic community-associated methicillin-resistant  Staphylococcus aureus : recent clonal expansion and diversification,”  Proc. Natl. Acad. Sci. U.S.A  105:1327-1332 (2008), which is hereby incorporated by reference in its entirety) labeled ‘18808-WT’ and a lukAB deletion derivative thereof (‘18808-ΔAB’), and (v)  S. aureus  USA 300 MRSA strain BK18809, a 2005 isolate from a bacteremia patient (Kennedy et al., “Epidemic community-associated methicillin-resistant  Staphylococcus aureus : recent clonal expansion and diversification,”  Proc. Natl. Acad. Sci. U.S.A  105:1327-1332 (2008), which is hereby incorporated by reference in its entirety) labeled ‘18809-WT’ and a lukAB deletion derivative thereof (‘18809-ΔAB’). 
     Procedure. 
       S. aureus  strains were grown overnight in RPMI+CAS medium and then sub-cultured 1:100 in RPMI+CAS and grown for a further 5 hours. The culture was thereafter normalized to 1×10 9  CFU/mL with PBS. 96-well plates were coated with 20% human serum for 20 mins at 37° C.+5% CO 2  and then washed twice with RPMI plus 10 mM HEPES (RPMI-H). 75 μl of a freshly prepared preparation of purified human primary polymorphonuclear leukocytes (PMNs) was then added to each test well corresponding to ˜200,000 cells per well and the plate incubated at room temperature (RT) for 30 mins. 10 μL of Test Articles (at 1.25 mg/mL) were added to appropriate wells to achieve a final concentration of 125 μg/mL. 20 μL of pre-diluted bacteria were then added per well to yield a multiplicity of infection (MOI) of ˜25. Following a two hour incubation at 37° C. in 5% CO 2 , the plates were centrifuged for 5 mins at 1,500 RPM at 4° C. and assessment of cytolysis determined by lactate dehydrogenase (LDH) release. For this, 25 μL of the supernatants from each test well were transferred into a new black, clear bottom 96-well plate and 25 μL of CytoTox-ONE™ Assay reagent (Promega) was added and the plate incubated in the dark for 15 mins. CytoTox-ONE™ Assay reagent measures the release of LDH from cells with a damaged membrane via a coupled enzymatic assay that results in the conversion of resazurin into a fluorescent resorufin product detected via plate reading in a spectrometer. Test articles evaluated were CNTO3930 (Construct 21 in Table 1; SEQ ID NO: 104 HC plus SEQ ID NO: 105 LC), mAb 5133 PRASA A6 (Construct 4 in Table 1; SEQ ID NO: 66 HC plus SEQ ID NO: 67 LC), mAb 5133 PRASA A6 HC-L4-E-L4-AB (Construct 11 in Table 1; SEQ ID NO: 856 HC plus SEQ ID NO: 67 LC) and mAb 5133 PRASA A6 HC-L4-E-L1-AB (Construct 12 in Table 1; SEQ ID NO: 952 HC plus SEQ ID NO: 67 LC). 
     Results. 
       FIG. 16  shows the relative activity of the test articles in protecting primary human neutrophils from cytolysis following incubation with a series of pairs of otherwise-isogenic strains that differ only in the expression of the LukAB leukotoxin—as determined by release of LDH. 
     In these studies, CNTO3930 and mAb 5133 PRASA A6 afforded the least protection of primary human neutrophils from killing mediated by all LukAB producing strains as indicated by the maximal LDH release observed. That this killing is dependent on LukAB production is supported by the observation that no LDH release is observed in the presence of either CNTO3930 or mAb 5133 PRASA A6 when strains lacking LukAB expression are employed. In contrast, both mAb5133-FN3 fusion proteins studied that bind and neutralize LukAB, i.e., mAb 5133 PRASA A6 HC-L4-E-L4-AB and mAb 5133 PRASA A6 HC-L4-E-L1-AB, afforded protection of primary human neutrophils from killing mediated by all LukAB producing strains as indicated by reduced LDH release with mAb 5133 PRASA A6 HC-L4-E-L4-AB typically affording somewhat enhanced protection over mAb 5133 PRASA A6 HC-L4-E-L1-AB. As expected, killing in the presence of mAb 5133 PRASA A6 HC-L4-E-L4-AB and mAb 5133 PRASA A6 HC-L4-E-L1-AB was observed to be dependent on the production of LukAB. 
     Summary. 
     These data indicate that mAb 5133-FN3 fusion proteins that bind and neutralize the cytolytic activity of leukotoxins LukAB are capable of protecting human primary neutrophils from leukotoxin-mediated killing. This activity of mAb 5133-FN3 fusion proteins targeting LukAB may be of therapeutic utility in the context of  S. aureus  mediated human infections. 
     Example 17: mAb5133-FN3 Fusion Proteins Protect Primary Human Neutrophils from Extracellular Killing by Non-Cognate Leukotoxin Pairs LukE/LukF-PV and LukE/HlgB 
     Based on the genetic arrangements of genes encoding leukocidins and the co-regulation of loci encoding S and F subunits and the purification and characterization of native proteins, five cognate leukocidins have been identified in  S. aureus : LukAB, LukS-PV/LukF-PV, LukED, HlgAB and HlgCB (Alonzo and Torres, “The bicomponent pore-forming leucocidins of  Staphylococcus aureus,” Microbiol. Mol. Biol. Rev.  78(2): 199-230 (2014), which is hereby incorporated by reference in its entirety). However, with the exception of LukAB that is produced as a native heterodimer, a number of studies have reported that active leukocidins can be prepared through combination of non-cognate pairs of recombinant S and F subunits (Gravet et al., “Characterization of a novel structural member, LukE-LukD, of the bi-component staphylococcal leukotoxins family,”  FEBS Letters  436: 202-208 (1998); Morinaga et al., “Purification, Cloning and Characterization of Variant LukE-LukD with Strong Leukocidal Activity of Staphylococcal Bi-Component Leukotoxin Family,”  Microbiol. Immunol.  47(1): 81-90 (2003); Rouha et al., “Five birds, one stone: Neutralization of alpha-hemolysin and four bi-component leukocidins of  Staphylococcus aureus  with a single monoclonal antibody,” MAbs. 7(1): 243-54 (2015), which are hereby incorporated by reference in their entirety) and include the non-cognate pairs LukE/LukF-PV and LukE/HlgB. The studies described herein exemplify the ability of mAb5133-FN3 fusion proteins that bind and neutralize leukotoxins LukED (and LukAB) to afford protection of primary human neutrophils from extracellular killing mediated by LukE/LukF-PV and LukE/HlgB. 
     Procedure. 
     Recombinant variants of LukE, LukF-PV and HlgB subunits were individually prepared from  S. aureus . To demonstrate the leukocidal activity of the non-cognate leukocidins LukE/LukF-PV and LukE/HlgB, individual subunits were combined on an equal weight basis with 200,000 freshly purified human primary polymorphonuclear leukocytes (PMNs) in RPMI+10 mM HEPES in a total volume of 100 μL and incubated for one hour at 37° C. in a CO 2  incubator. 25 μl of supernatant was then carefully transferred to a new plate after spinning the plate down at 1500 RPM for 10 mins and cell lysis determined using the Cell Titer reagent (Promega) based on quantitation of the ATP present, an indicator of metabolically active cells. To determine the relative activity of mAb5133-FN3 fusion proteins in neutralizing the cytolytic activity of LukE/LukF-PV and LukE/HlgB leukotoxins against human PBMCs, 2.5 μg of LukE and 2.5 μg of HlgB, or 5 μg of LukE plus 5 μg of HlgLukF-PV, were combined with increasing concentrations of each test article and incubated on ice for 20 minutes. Freshly isolated primary human neutrophils (hPMNs, 200,000 cells in 70 μl of RPMI+10 mM HEPES+0.1% HSA) were then added and the mixtures incubated for 1-hour at 37° C. in a 5% CO 2  incubator. The reaction plates were then centrifuged for 5 mins at 1,500 RPM at 4° C. and assessment of cytolysis determined by lactate dehydrogenase (LDH) release. For this, 25 μL of the supernatants from each test well were transferred into a new black, clear bottom 96-well plate, 25 μL of CytoTox-ONE™ Assay reagent (Promega) was added, and the plate incubated in the dark for 15 mins. CytoTox-ONE™ Assay reagent measures the release of LDH from cells with a damaged membrane via a coupled enzymatic assay that results in the conversion of resazurin into a fluorescent resorufin product detected via plate reading in a spectrometer. Test articles evaluated were CNTO3930 (Construct 21 in Table 1; SEQ ID NO: 104 HC plus SEQ ID NO: 105 LC), mAb 5133 PRASA A6 HC-L4-E-L4-AB (Construct 11 in Table 1; SEQ ID NO: 856 HC plus SEQ ID NO: 67 LC) and mAb 5133 PRASA A6 HC-L4-E-L1-AB (Construct 12 in Table 1; SEQ ID NO: 952 HC plus SEQ ID NO: 67 LC). As additional controls, purified LukED toxin (at a final concentration of 2.5 μg/mL) was added to reactions containing either CNTO3930 or mAb 5133 PRASA A6 HC-L4-E-L1-AB. 
     Results.  FIG. 17A  shows the relative cytolytic activity of the cognate LukED and non-cognate LukE/LukF-PV and LukE/HlgB leukotoxins for primary human neutrophils with concentration-dependent lysis observed for all test articles with the apparent potency under these conditions LukE/HlgB&gt;LukED&gt;LukE/LukF-PV.  FIG. 17B  shows the relative activity of CNTO3930 and two mAb5133-FN3 fusion proteins in protecting primary human neutrophils from LukE/LukF-PV mediated cytolysis, as determined by the release of LDH. As expected, the anti-RSV CNTO3930 antibody affords no apparent protection from LukE/LukF-PV cytolysis and overall cell killing was not impacted by addition of LukED. In contrast, both mAb 5133 PRASA A6 HC-L4-E-L4-AB and mAb 5133 PRASA A6 HC-L4-E-L1-AB afforded concentration-dependent protection from LukE/LukF-PV mediated cytolysis with the addition of LukED to mAb 5133 PRASA A6 HC-L4-E-L1-AB exhibiting somewhat reduced overall neutralization activity. Similarly, as shown in  FIG. 17C  (top and bottom panels), the anti-RSV CNTO3930 antibody affords no apparent protection from LukE/HlgB mediated cytolysis, and overall cell killing was not impacted by addition of LukED. In contrast, both mAb 5133 PRASA A6 HC-L4-E-L4-AB and mAb 5133 PRASA A6 HC-L4-E-L1-AB afforded concentration-dependent protection from LukE/HlgB mediated cytolysis with the addition of LukED to mAb 5133 PRASA A6 HC-L4-E-L1-AB exhibiting somewhat reduced overall neutralization activity. 
     Summary. 
     These data indicate that mAb 5133-FN3 fusion proteins that bind LukE and neutralize the cytolytic activity of the LukED leukocidin are also capable of protecting human primary neutrophils from cytolytic killing mediated by two non-cognate leukocidins bearing the LukE subunit—namely, LukE/LukF-PV and LukE/HlgB. This broader leukocidin-neutralizing activity of mAb 5133-FN3 fusion proteins targeting LukE may be of therapeutic utility in the context of  S. aureus  mediated human infections. 
     Example 18: Neutralization of LukED Mediated Hemolysis of Human Red Blood Cells by mAb5133-FN3 Fusion Proteins 
     A key feature of the pathogenesis of  S. aureus  in the bloodstream is the scavenging of iron through the production of toxins that lyse erythrocytes, releasing hemoglobin, the most abundant iron source in mammals. In recent studies the Duffy antigen receptor for chemokines (DARC) was identified as the receptor for the  S. aureus  hemolytic leukocidins LukED and HlgAB (Spaan et al., “ Staphylococcus aureus  Targets the Duffy Antigen Receptor for Chemokines (DARC) to Lyse Erythrocytes,”  Cell Host  &amp; Microbe  18(3): p. 363-370 (2015), which is hereby incorporated by reference in its entirety). Herein it is demonstrated that a mAb5133-FN3 fusion protein that exhibits LukED toxin neutralization activity as determined in assays employing freshly isolated hPMNs (see EXAMPLE 4), also protects human erythrocytes (red blood cells) from LukED-mediated hemolysis. 
     Procedure. 
     A constant concentration of 4.8 μg/mL per subunit of recombinant LukED (corresponding to the mouse LD 90  concentration) in a volume of 40 μL was incubated with increasing concentrations of either mAb 5133 PRASA A6 (Construct 4 in Table 1; SEQ IDs #66 HC plus 67 LC) or mAb 5133 PRASA A6 HC-L4-E-L4-AB (Construct 11 in Table 1; SEQ IDs #856 HC plus 67 LC) in a total volume of 80 μL for 30 mins on ice. Blood from fresh human leukopaks was washed three times in 0.9% saline and red blood cells (RBCs) at 8×10 7  cells in 0.9% saline in a volume of 80 μL were added to the toxin-test article mixture in a 96-well plate. Two control reactions were also run in parallel: (i) LukED and RBCs alone with no test articles, and (ii) RBCs alone with 0.2% Triton-X100 with no test articles or LukED. After 30 mins of intoxication/incubation at 37° C. in the presence of 5% CO 2 , plates were spun down for 10 minutes at 1780 g at 4° C. 100 μL of the cell free lysates were then transferred to a new 96-well plate and the OD 405  nm was measured as a measure of hemolysis. The data shown in  FIGS. 18A and 18B  is compiled from the results of studies using three individual blood donors. The extent of hemolysis (expressed as a %) was determined using the following formulation: 
     
       
         
           
             ( 
             
               ( 
               
                 
                   
                     
                       OD 
                       
                         405 
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                         m 
                       
                     
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                       Cells 
                       ⁢ 
                       
                           
                       
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                       ⁢ 
                       
                           
                       
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                       average 
                     
                   
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                     Triton 
                     ⁢ 
                     
                         
                     
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                     Toxin 
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     Results. 
       FIG. 18B  shows the % hemolysis observed with LukED in the presence of mAb 5133 PRASA A6 or mAb 5133 PRASA A6 HC-L4-E-L4-AB as compared to the 100% value observed with LukED alone. As expected, only the mAb 5133 PRASA A6 HC-L4-E-L4-AB test article that bears a LukED neutralizing FN3 domain is observed to protect erythrocytes from LukED mediated hemolysis.  FIG. 18A  shows the % hemolysis observed with LukED in the presence of mAb 5133 PRASA A6 or mAb 5133 PRASA A6 HC-L4-E-L4-AB as compared to the 100% value observed with Triton-X100 alone. Similarly, only the mAb 5133 PRASA A6 HC-L4-E-L4-AB test article that bears a LukED neutralizing FN3 domain is observed to protect erythrocytes from LukED mediated hemolysis. 
     Summary. 
     These data indicate that mAb 5133-FN3 fusion proteins that bind LukE and neutralize the cytolytic activity of the LukED leucocidin versus hPMNs also neutralize the hemolytic activity of the LukED leucocidin versus human erythrocytes. LukED cytolysis of hPMNs is thought to be mediated following target cell engagement via the CXCR1/CXCR2 receptors whereas the hemolysis of erythrocytes is mediated following target cell engagement via the DARC receptor. Hence, these data support the notion that neutralization of the cytolytic activities of LukED mediated by mAb 5133-FN3 fusion proteins can be independent of the nature of target cell engagement as conferred by specific target cell receptors. 
     Example 19: Identification of Potential Neutralization Epitopes on Leukocidin LukAB by Solution Phase Hydrogen/Deuterium Exchange (HDX)-Mass Spectrometry (MS) 
     For higher order structural studies, hydrogen-deuterium exchange coupled with mass spectrometry analysis, referred to herein as HDX-MS, has proven a valid method in the identification of binding surfaces between interacting proteins (Hamuro et al., “Rapid Analysis of Protein Structure and Dynamics by Hydrogen/Deuterium Exchange Mass Spectrometry,”  J. of Biomolecular Techniques  14: 171-182 (2003) and Hom et al., “The Role of Protein Dynamics in Increasing Binding Affinity for an Engineered Protein-Protein Interaction Established by H/D Exchange Mass Spectrometry,”  Biochemistry  45: 8488-8498 (2006), which are hereby incorporated by reference in their entirety). Herein are described studies to identify the potential binding epitope(s) for the Luk17 FN3 protein (SEQ ID NO: 14) on the LukAB heterodimer by solution phase HDX-MS methods using a recombinant toxoid variant (LukA E323A) of LukAB protein produced from  Staphylococcus aureus  (SEQ ID NOs: 10 &amp; 11). Recombinant LukAB heterodimer in the absence or presence of Luk17 FN3 was incubated in a deuterated water solution for predetermined times resulting in deuterium incorporation at exchangeable hydrogen atoms. Regions bound to the Luk17 FN3 protein were inferred to be those sites relatively protected from hydrogen-deuterium exchange and thus contain a lower fraction of deuterium than the reference LukAB protein in studies in which more than 99% of the LukAB protein was mapped to specific peptides. 
     Procedures. 
     Pepsin/protease type XIII digestion and LC-MS: for pepsin/protease type XIII digestion, 5 μg of LukAB in 125 μL control buffer (50 mM phosphate, 100 mM sodium chloride at pH 7.4) was denatured by adding 63 μL of 5 M guanidine hydrochloride (final pH 2.5) and incubating the mixture for 3 min. The mixture was then subjected to on-column pepsin/protease type XIII digestion and the resultant peptides were analyzed using an Ultra Performance Liquid Chromatography Mass Spectrometry (UPLC-MS) system comprised of a Waters Acquity UPLC coupled to a Q Exactive™ Hybrid Quadrupole-Orbitrap Mass Spectrometer (Thermo). The peptides were separated on a 50 mm×1 mm C8 column with a 16.5 min gradient from 2-32% solvent B (0.1% formic acid in acetonitrile). Solvent A was 0.02% trifluoroacetic acid and 0.08% formic acid in water. The injection valve and pepsin/protease type XIII column and their related connecting tubes were housed inside a cooling box maintained at 11° C. And the second switching valve, C8 column and their related connecting stainless steel tubes were housed inside a chilled circulating box maintained at 0° C. Peptide identification was done through searching MS/MS data against the LukAB sequence using the Mascot software package (Koenig et al., “Robust prediction of the MASCOT score for an improved quality assessment in mass spectrometric proteomics,”  J. Proteome Res.  7 (9): 3708-17 (2008), which is hereby incorporated by reference in its entirety). The mass tolerance for the precursor and product ions was 20 ppm and 0.05 Da, respectively. 
     H/D Exchange: 5 μL LukAB (10 μg) or 5 μL of the complex of LukAB and Luk17 FN3 protein (10 &amp; 7.35 rig, respectively) were incubated with 120 μL deuterium oxide labeling buffer (50 mM phosphate, 100 mM sodium chloride at pH 7.4) for 0 sec, 60 sec, 300 sec, 1800 sec, 7200 sec, and 14400 sec. Deuterium exchange was quenched by adding 63 μL of 5 M guanidine hydrochloride (final pH is 2.5) and the quenched sample was then subjected to on-column pepsin/protease type XIII digestion and LC-MS analysis as described above. The mass spectra were recorded in MS only mode. Raw MS data was processed using HDX WorkBench software for the analysis of H/D exchange MS data (Pascal et al., “Software for the Analysis of H/D Exchange MS Data,”  J Am. Soc. Mass Spectrometry  23 (9), 1512-1521 (2012), which is hereby incorporated by reference in its entirety). The deuterium levels were calculated using the average mass difference between the deuterated peptide and its native form (to). 
     Results. 
     To establish at the peptide level interaction site(s) on LukAB targeted by the Luk17 FN3 protein, LukAB was incubated in deuterium oxide either alone or in complex with the Luk17 FN3 protein. The deuterium exchange was carried at room temperature for 0 s, 60 sec, 300 sec, 1800 sec, 7200 sec, and 14400 sec. The deuterium levels of the identified peptides were monitored from the mass shift on LC/MS. LukA did not show any significant reduction in deuterium uptakes upon binding to the Luk17 FN3 protein. In contrast, while most of the LukB peptides displayed identical or similar deuterium levels with and without the Luk17 FN3 protein molecule, two discrete peptides of LukB had significant decreased deuterium incorporation upon Luk17 FN3 protein binding. Specifically, the LukB peptide region  260 IDWNRHGFWG 269  (amino acid residue 260-269 of SEQ ID NO: 11) experienced strong deuterium protection. This strongly protected region is thus assigned as a potential component of the epitope for the Luk17 FN3 protein. In addition, the HDX-MS analysis also showed one marginally protected segment,  201 LTRNGNLWAKDNFTPKDKMPVTVS 224  (amino acid residues 201-224 of SEQ ID NO: 11). These two regions protected by solution phase interaction of the Luk17 FN3 protein with LukB (SEQ ID NO: 11) are highlighted in black ( 260 IDWNRHGFWG 269 ; peptide #1) and dark grey ( 201 LTRNGNLWAKDNFTPKDKMPVTVS 224 ; peptide #2) in the differential LukB heat map schematic shown in  FIG. 19  A. 
     These two putative LukAB/Luk17 FN3 protein interaction sites were mapped onto the published octameric crystal structure of the bi-component toxin LukAB (aka, LukGH) (Badarau et al., “Structure-Function Analysis of Heterodimer Formation, Oligomerization, and Receptor Binding of the  Staphylococcus aureus  Bi-component Toxin LukGH,”  J. Biol. Chem.  290, 142-156 (2015), which is hereby incorporated by reference in its entirety) and are shown in  FIG. 19  B. Interestingly, the two identified linear peptides of LukB lie in close proximity to each other in the three dimensional crystal structure. This conclusion is further substantiated by mapping of the same peptides on a heterodimeric LukAB structure described herein (see EXAMPLE 21). These data suggest that the LukAB neutralization epitope of the Luk17 FN3 protein is defined by residues encompassed within the LukB peptide sequences  260 IDWNRHGFWG 269  and  201 LTRNGNLWAKDNFTPKDKMPVTVS 224  (of SEQ ID NO: 11). 
     Summary. 
     These data indicate that the Luk17 FN3 protein binds LukAB via specific interaction(s) with the LukB subunit. Based on models for the association of LukAB with the target cell receptor CD11b (Badarau et al., “Structure-Function Analysis of Heterodimer Formation, Oligomerization, and Receptor Binding of the  Staphylococcus aureus  Bi-component Toxin LukGH,”  J. Biol. Chem.  290, 142-156 (2015), which is hereby incorporated by reference in its entirety) (see EXAMPLE 21) and subsequent association at the target cell membrane in forming an octameric pore, it is assumed that Luk17 FN3 protein mediated neutralization of the cytolytic activity of LukAB occurs through perturbation of LukAB binding to target cells and/or the conformational transitions of LukAB associated with octameric pore formation in target cell membranes. 
     Example 20: Identification of Potential LukED Neutralization Epitopes on the Leukocidin LukE Subunit by Solution Phase Hydrogen/Deuterium Exchange (HDX)-Mass Spectrometry (MS) 
     Herein are described studies to identify the potential binding epitope(s) for the Luk26 FN3 protein (SEQ ID NO: 25) on the LukE subunit structure by solution phase HDX-MS methods using recombinant LukE protein produced from  Staphylococcus aureus  (SEQ ID NO: 1055). In these studies, recombinant LukE protein in the absence or presence of the Luk26 FN3 protein was incubated in a deuterated water solution for predetermined times resulting in deuterium incorporation at exchangeable hydrogen atoms. Regions bound to the Luk26 FN3 protein were inferred to be those sites relatively protected from exchange and thus contain a lower fraction of deuterium than the reference LukE protein in studies in which more than 99% of the LukE protein was mapped to specific peptides. 
     Procedures. 
     Pepsin/protease type XIII digestion and LC-MS: for pepsin/protease type XIII digestion, 5 μg of LukE protein in 125 μL control buffer (50 mM phosphate, 100 mM sodium chloride at pH 7.4) was denatured by adding 63 μL of 5 M guanidine hydrochloride (final pH 2.5) and incubating the mixture for 3 min. The mixture was then subjected to on-column pepsin/protease type XIII digestion and the resultant peptides were analyzed using an Ultra Performance Liquid Chromatography Mass Spectrometry (UPLC-MS) system comprised of a Waters Acquity UPLC coupled to a Q Exactive™ Hybrid Quadrupole-Orbitrap Mass Spectrometer (Thermo). The peptides were separated on a 50 mm×1 mm C8 column with a 16.5 min gradient from 2-32% solvent B (0.1% formic acid in acetonitrile). Solvent A was 0.02% trifluoroacetic acid and 0.08% formic acid in water. The injection valve and pepsin/protease type XIII column and their related connecting tubes were housed inside a cooling box maintained at 11° C. And the second switching valve, C8 column and their related connecting stainless steel tubes were housed inside a chilled circulating box maintained at 0° C. Peptide identification was done through searching MS/MS data against the LukAB sequence using the Mascot software package (Koenig et al., “Robust prediction of the MASCOT score for an improved quality assessment in mass spectrometric proteomics,”,  J. Proteome Res.  7 (9): 3708-17 (2008), which is hereby incorporated by reference in its entirety). The mass tolerance for the precursor and product ions was 20 ppm and 0.05 Da, respectively. 
     H/D Exchange: 5 μL of LukE (5 μg) protein alone or 5 μL of LukE plus the Luk26 FN3 protein (5 and 3.93 μg, respectively) were incubated with 120 μL deuterium oxide labeling buffer (50 mM phosphate, 100 mM sodium chloride at pH 7.4) for 0 sec, 60 sec, 300 sec, 1800 sec, 7200 sec, and 14400 sec. Deuterium exchange was quenched by adding 63 μL of 5 M guanidine hydrochloride (final pH is 2.5) and the quenched sample was then subjected to on-column pepsin/protease type XIII digestion and LC-MS analysis as described above. The mass spectra were recorded in MS only mode. Raw MS data was processed using HDX WorkBench software for the analysis of H/D exchange MS data (Pascal et al., “Software for the Analysis of H/D Exchange MS Data,”  J. Am. Soc. Mass Spectrometry  23 (9), 1512-1521 (2012), which is hereby incorporated by reference in its entirety). The deuterium levels were calculated using the average mass difference between the deuterated peptide and its native form (to). 
     Results. 
     To establish at the peptide level interaction site(s) on LukE targeted by the Luk26 FN3 protein, LukE was incubated in deuterium oxide either alone or in complex with the Luk26 FN3 protein. The deuterium exchange was carried at room temperature for 0 s, 60 sec, 300 sec, 1800 sec, 7200 sec, and 14400 sec. The deuterium levels of the identified peptides were monitored from the mass shift on LC/MS. While most of the LukE peptides displayed identical or similar deuterium levels with and without Luk26 Fn3 protein, two peptide segments showed significantly decreased deuterium incorporation upon binding. Specifically, LukE shows significant reduction in deuterium uptake upon binding to Luk26 Fn3 protein at peptide regions,  69 TSFSDVKGSGYELT 82  and  255 LFPRTGIYAERKHNAFVNRNF 275 —as per the amino acid numbering used in SEQ ID No: 1055 (these regions correspond to amino acid residues 86-99 of SEQ ID NO: 1054 and 272-292 of SEQ ID NO: 1054, respectively). These two regions protected by the Luk26 FN3 protein are highlighted in black in the differential heat map schematic shown in  FIG. 20  A. These regions are thus assigned as the major interaction sites for the Luk26 Fn3 protein on LukE. In addition, the HDX-MS analysis also showed one marginally protected segment,  244 YGRN 247  (of SEQ ID NO: 1055) and is highlighted in dark grey in the differential heat map schematic shown in  FIG. 20  A. This region corresponds to amino acid residues 261-264 of SEQ ID NO: 1054) 
     These putative LukE/Luk26 FN3 protein interaction sites were mapped on the published high-resolution crystal structure of Luk E (Nocadello et al., “Crystal structures of the components of the  Staphylococcus aureus  leukotoxin ED”  Acta. Cryst. D 72: 113-120 (2016) PDB entry 3roh, which is hereby incorporated by reference in its entirety). These interaction sites were found to lie in close proximity to each other in the three dimensional structure (see highlighted regions of  FIG. 20B ) and comprise elements of the so-called ‘rim’ domain of LukE. Subsequent mutational mapping of LukE indicated that residues of each of the putative LukE/Luk26 FN3 protein interaction site impacted binding to the Luk26 FN3 protein (see EXAMPLE 23 infra). 
     Summary. 
     These data indicate that the Luk26 FN3 protein binds LukE via specific interaction(s) in the rim domain region and this binding is sufficient to neutralize the cytolytic (EXAMPLE 4) and hemolytic activity (EXAMPLE 19) of LukED. As the rim domains of leukotoxins are thought to be important for interaction with the lipid bilayer of target cell membranes and for interaction with specific target cell membrane-bound receptors, it is possible that the binding of the Luk26 FN3 protein to LukE perturbs either receptor engagement, membrane binding and/or the formation of LukED heterodimers and/or higher oligomers at the surface of the membrane. In the case of LukED, Luk26 FN3 protein mediate blocking of receptor engagement could occur via perturbation of interaction with the Duffy antigen receptor for chemokines (DARC) on red blood and endothelial cells (Spaan et al., “ Staphylococcus aureus  Targets the Duffy Antigen Receptor for Chemokines (DARC) to Lyse Erythrocytes,”  Cell Host Microbe  18(3):363-70 (2015), which is hereby incorporated by reference in its entirety) or via perturbation of interactions with the chemokine receptors CXCR1 and CXCR2 on neutrophils (Spaan et al., “ Staphylococcus aureus  Leukotoxin ED Targets the Chemokine Receptors CXCR1 and CXCR2 to Kill Leukocytes and Promote Infection,”,  Cell Host Microbe  14(4): 453-459 (2013), which is hereby incorporated by reference in its entirety). 
     Example 21: Characterization of the Neutralization Epitope of the Luk17 FN3 Protein on LukAB by X-Ray Crystallography 
     Herein are described studies to identify the binding epitope for the Luk17 FN3 protein on leukotoxin LukAB by determination of a high resolution X-ray crystal structure of a ternary complex (1:1:1) comprised of the Luk17 FN3 protein, LukAB and a LukAB-specific Fab (fragment, antigen-binding). 
     Procedures. 
     Proteins. The proteins used for the structural studies described herein are (i) a recombinant toxoid variant (LukA E323A) of LukAB protein produced from  Staphylococcus aureus  (SEQ ID NOs: 10 &amp; 11) referred to herein as ‘LukAB’, (ii) a poly-histidine tagged variants of the Luk17 FN3 protein (SEQ ID NO: 1053) referred to herein as ‘S17’, and (iii) a recombinant Fab (SEQ ID NOs: 1078 HC plus 1079 LC; construct 34 in Table 1) derived from a LukAB-specific mAb (SEQ ID NOs: 1080 HC plus 1081 LC; construct 35 in Table 1) and herein referred to as ‘214F’. LukAB was purified at a final concentration of 5 mg/mL in 10 mM Na acetate, pH 5.5. The Luk17 FN3 protein purified at a final concentration of 8.4 mg/mL in 25 mM Tris, pH 7.4, 50 mM NaCl. 214F was purified at a final concentration of 1.91 mg/mL in 20 mM MES, 200 mM NaCl, pH 6.0. 
     Complex Formation, Crystallization and X-Ray Data Collection. 
     A ternary complex consisting of LukAB, the Luk17 FN3 protein and 214F was prepared by incubation of LukAB with excess Luk17 FN3 and 214F. The complex was purified by cation exchange chromatography on a Mono S5/50 GL column (GE Healthcare) pre-equilibrated in 20 mM HEPES pH 7.5, 10% glycerol. After loading the sample on the column, the ternary complex was eluted with a linear gradient of 20 mM HEPES pH 7.5, 10% glycerol, 1 M NaCl. Fractions were analyzed by SDS-PAGE to confirm the presence of the ternary complex. Fractions containing the purified LukAB/Luk17 FN3/214F complex were pooled and concentrated to 13.42 mg/mL in 20 mM HEPES pH 7.5, 100 mM NaCl, 10% glycerol. Crystallization screening and optimization was performed using a Mosquito crystallization robot (TTP Labtech) with seeding using seeds of the ternary complex. A crystal was harvested from 0.1 M MES pH 6.5, 26% PEG 3350, 0.2M diammonium tartrate and mixed with cryoprotectant solution composed of 0.1 M MES pH 6.5, 25% PEG 3350, 0.2 M diammonium tartrate, 20% glycerol. The crystal was flash-cooled in liquid nitrogen. The diffraction data were collected at Advanced Photo Source (beamline 17-ID) at the Argonne National Laboratory. The X-ray data were processed with “XDS” (Kabsch, W.,  Acta. Crystallogr. D. Biol. Crystallogr.  66(2): 125-132 (2010), which is hereby incorporated by reference in its entirety) to a resolution of 3 Å. The details of the X-ray data are summarized in Table 2 below. 
     Structure Determination. 
     The structure of the ternary complex was solved by molecular replacement with Phaser (Read, “Pushing the boundaries of molecular replacement with maximum likelihood,”  Acta. Crystallogr. D. Biol. Crystallogr.  57(10): 1373-1382 (2001), which is hereby incorporated by reference in its entirety) in several steps. The LukAB dimer from pdb ID 4tw1 (Badarau et al., “Structure-Function Analysis of Heterodimer Formation, Oligomerization, and Receptor Binding of the  Staphylococcus aureus  Bi-component Toxin LukGH,”  J. Biol. Chem.  290, 142-156 (2015), which is hereby incorporated by reference in its entirety) was used as a template after the pore forming segments were manually removed. The 214F Fab was located using a homology model of the Fv generated in MOE (CCG, Montreal) and the two constant domains from 3na9 (Luo et al., “Coevolution of antibody stability and Vkappa CDR-L3 canonical structure,”  J. Mol. Biol.  402(4): 708-719 (2010), which is hereby incorporated by reference in its entirety). Finally, the S17 was located using a homology model based upon a monomer from pdb id 3tes (Jacobs et al., “Design of novel FN3 domains with high stability by a consensus sequence approach,”  Protein Eng. Des. Sel.  25(3): 107-117 (2012), which is hereby incorporated by reference in its entirety). Refinement was carried out with Phenix (Adams et al., “Recent developments in the PHENIX software for automated crystallographic structure determination,”  J. Synchrotron Radiat.  11(1): 53-55 (2004), which is hereby incorporated by reference in its entirety) and model fitting with COOT (Emsley et al., “Coot: model-building tools for molecular graphics,”  Acta. Crystallogr. D. Biol. Crystallogr.  60(12 Pt 1): 2126-2132 (2004), which is hereby incorporated by reference in its entirety). The refinement statistics are summarized in Table 2. All graphics was generated with Pymol (Schrodinger LLC., www.pymol.org) and all other calculations were carried out in CCP4 (Collaborative Computational Project 1994). 
     
       
         
           
               
             
               
                 TABLE 2 
               
               
                   
               
               
                 X-ray data statistics and refinement statistics for high  
               
               
                 resolution X-ray crystal structure of a ternary complex  
               
               
                 (1:1:1) comprised of the Luk17 FN3 protein,  
               
               
                 LukAB and a LukAB-specific 
               
               
                   
               
             
            
               
                 Data collection 
               
            
           
           
               
               
               
               
            
               
                   
                 Wavelength (Å) 
                 1.000  
                 (APS) 
               
            
           
           
               
               
               
            
               
                   
                 Temperature (K) 
                 95 
               
               
                   
                 Space group 
                 C 222 1   
               
               
                   
                 Unit cell axes (Å) 
                 92.98, 173.74, 174.31 
               
               
                   
                 Unit cell angles (°) 
                 90, 90, 90 
               
               
                   
                 Molecules/asymmetric unit 
                 1 LukAB/S17/214F complex 
               
            
           
           
               
               
               
               
            
               
                   
                 Resolution (Å) 
                 50-3.00 
                 (3.08-2.80)* 
               
               
                   
                 No. measured reflections 
                 106,449 
                 (7,215) 
               
               
                   
                 No. unique reflections 
                 27,208 
                 (1,888) 
               
               
                   
                 Completeness (%) 
                 95.0 
                 (90.5) 
               
               
                   
                 Redundancy 
                 3.9 
                 (3.8) 
               
               
                   
                 R merge   
                 0.150 
                 (1.000) 
               
               
                   
                 R p.i.m.   
                 0.079 
                 (0.515) 
               
               
                   
                 CC1/2 
                 0.99 
                 (0.62) 
               
               
                   
                 &lt;I/σ&gt; 
                 10.5  
                 (1.9) 
               
            
           
           
               
               
               
            
               
                   
                 B-factor (Wilson) (Å 2 ) 
                 63.8 
               
            
           
           
               
            
               
                 Structure Refinement 
               
            
           
           
               
               
               
               
            
               
                   
                 Resolution (Å) 
                 49.16-3.00  
                 (3.11-3.00) 
               
               
                   
                 No. reflections in refinement 
                 27,197  
                 (2,604) 
               
            
           
           
               
               
               
            
               
                   
                 Number of atoms 
                 8,641 
               
               
                   
                 Number of solvent atoms 
                 0 
               
            
           
           
               
               
               
               
            
               
                   
                 R cryst  (%) 
                 19.6  
                 (32.4) 
               
               
                   
                 R free  (5% data) (%) 
                 24.7  
                 (38.8) 
               
            
           
           
               
               
               
            
               
                   
                 RMSD bond lengths (Å) 
                 0.003 
               
               
                   
                 RMSD bond angles (°) 
                 0.53 
               
               
                   
                 RMS B-factor bonded (Å 2 ) 
                 9.2 
               
               
                   
                 Mean B factors (Å 2 ) 
                 63.6 
               
               
                   
                 Ramachadran plot 
                   
               
               
                   
                 Favored (%) 
                 94.2 
               
               
                   
                 Allowed (%) 
                 5.6 
               
               
                   
                 Outliers (%) 
                 0.2 
               
               
                   
                   
               
               
                   
                 *Values for highest resolution shell are in ( )&#39;s. 
               
               
                   
                 Fab (fragment, antigen-binding) designated ‘214F’ 
               
            
           
         
       
     
     Results. 
     The overall structure of the LukAB/S17/214F ternary complex is shown in  FIG. 21A . The structural model includes one LukAB heterodimer (residues of 16-305 of LukA, residues 41-323 of LukB—numbering as per PDB ID 4tw1), one 214F molecule (residues 1-213 of the light chain, residues 1-224 of the heavy chain) and one S17 molecule (residues 1-94 of centyrin S17 including the initiation methionine (Ml) and two His residues of the C-terminal 6×-His Tag)). 
     The LukAB in the ternary complex is a heterodimer with the LukA/LukB interface corresponding to interface 2 of the previously determined LukAB structure and is consistent with a published mutational analysis of the subunit interface (Badarau et al., “Structure-Function Analysis of Heterodimer Formation, Oligomerization, and Receptor Binding of the  Staphylococcus aureus  Bi-component Toxin LukGH,”  J. Biol. Chem.  290, 142-156 (2015, which is hereby incorporated by reference in its entirety). The LukA and LukB monomer structures are very similar to those in the octamer structure (rmsds of 0.36 Å for 223 LukA Ca atoms and 0.34 Å for 224 LukB Ca atoms, respectively) except for the loop segments involved in the octamer formation. As is shown in  FIG. 21B , the pore-forming segments (residues 132-175 and 106-153 of LukA and LukB, respectively) adopt very different conformations in the isolated dimer. Interestingly, the switch points for the two conformations in LukA and LukB are identical in sequence as well as structure. 
     The binding sites for S17 and Fab 214F on LukAB are distant from the switching segments;  FIG. 21C . Thus, both molecules should be capable of binding the LukAB octamer as well as the LukAB heterodimer. The parental mAb of Fab 214F is known not to exhibit neutralizing activity against LukAB. In contrast, S17 exhibits LukAB neutralizing activity (EXAMPLE 5). Based on the localization of the S17 epitope on the octameric structure ( FIG. 21C ), it seems likely that S17 perturbs interaction with host cells either by blocking interaction with host cell receptors or sterically preventing insertion of the octameric pore into the membrane. 
     S17 binds the so-called rim domain of the LukB subunit ( FIGS. 21A-21B ) and does not make any apparent contact with the LukA subunit. Based on S17/LukB crystal contacts, the S17 binding epitope on LukAB is minimally composed of LukB residues: Y73, W74, N191, N192, R193, K195, N206, L207, W208, W262, N263, R264, H265, G266, F267, Y270 of SEQ ID NO: 11 ( FIG. 21D ). These epitope residues are largely consistent with the epitope segments identified by HDX mapping (EXAMPLE 19) and are also consistent with mutational analysis results (EXAMPLE 22).  FIG. 21F  shows representational electron density at the LukB epitope/Luk17 FN3 paratope interface. 
     S17 binds LukB via amino acid residues exposed on its concave surface corresponding to residues that are variant with respect to the parental FN3 binding protein (SEQ ID NO: 1). Based on S17/LukB crystal contacts, the residues that define the S17 paratope for binding LukB are Ml, W33, T35, E37, K39, F40, Y41, R42, A45, V47, E67, K69, W71, V73, W82 &amp; P83 and are highlighted in  FIG. 21E . These structural paratope residues are also consistent with mutational studies (EXAMPLE 5 &amp;  FIG. 5 ; note that the S17 numbering is shifted herein by one residue from EXAMPLE 5 as the amino-terminal methionine is included). Of note, key Luk17 FN3 paratope residues identified via the analysis on the LukAB binding and neutralization of site-directed variants of the Luk17 FN3 protein (see EXAMPLE 5 &amp;  FIG. 5 ) align with Luk17 FN3 paratope residues identified in the crystal structure. For example, Arg42, Glu37 and Lys39 in Luk17 FN3 (SEQ ID No: 1053; corresponding to Arg41, Glu36 and Lys38 in SEQ ID No: 14 and EXAMPLE 5) make specific crystal contacts with residues of the identified LukAB neutralization epitope for Luk17 FN3. 
     Summary. 
     The structure of the LukAB/S17/214F ternary complex reveals a complete LukAB heterodimer with the octamer-forming segments in very different conformations from those observed in a previously published octameric LukAB structure (Badarau et al., “Structure-Function Analysis of Heterodimer Formation, Oligomerization, and Receptor Binding of the  Staphylococcus aureus  Bi-component Toxin LukGH,”  J. Biol. Chem.  290: 142-156 (2015), which is hereby incorporated by reference in its entirety). The structurally defined epitope for the S17 (Luk17 FN3) protein on LukB is consistent with data from solution phase HDX mapping studies of LukAB (EXAMPLE 19) and the characterization of site-directed variants of LukB (EXAMPLE 22). Finally, the structure may also indicate an interesting neutralization mechanism for S17 wherein the interaction of LukAB with the target cell receptor (CD11b) and/or cell membrane is sterically blocked. In addition, it is possible that S17 binding prevents the normal conformational changes LukAB undergoes in transitioning from a heterodimer to an octameric, membrane embedded pore. 
     Example 22: Mutational Mapping of LukB to Confirm the LukAB Neutralization Epitope of the Luk17 FN3 Protein 
     Further to the characterization of site-directed mutants of the Luk17 FN3 protein in terms of LukAB binding and neutralization characteristics (EXAMPLE 5), herein are described equivalent studies to confirm specific Luk17 FN3/LukB interactions at the paratope/epitope interface as identified by determination of a high resolution X-ray crystal structure of a ternary complex (1:1:1) comprised of the Luk17 FN3 protein, LukAB and the ‘214F’ LukAB-specific Fab (see EXAMPLE 21). 
     Procedures. 
     The proteins used for the studies described herein are (i) site-directed LukB mutant variants of a recombinant toxoid variant of the LukAB protein (LukA E323A) that bear poly-histidine and streptavidin binding sequences at the amino-terminus of the LukA sequence and correspond to SEQ ID NOs: 1033-1052 (LukB variants) combined with SEQ ID NO: 1021 (LukA), and (ii) a variant of the Luk17 FN3 protein that bears a carboxyl-terminal poly-histidine sequence (SEQ ID NO: 1053). Recombinant LukAB variants were purified by nickel affinity chromatography as soluble heterodimers from an  E. coli  strain expressing biotin ligase. The Luk17 FN3 protein was purified from  E. coli  by nickel affinity chromatography. 
     Determination of Affinity (K D ) and Dissociation (K dis ) Constants. 
     K D  and K dis  values for the LukAB variants bearing site-directed mutations in LukB were determined by Bio-Layer Interferometry (BLI) using an Octet RED  384 instrument (forteBIO Inc.) running the basic kinetics protocol (“Biomolecular Binding Kinetics Assays on the Octet Platform”, at outlined in Application Note 14 from Pall forteBIO Corp. accessible via the ForteBIO websiste, which is hereby incorporated by reference in its entirety). Briefly, biotinylated LukAB mutant proteins were loaded onto Dip and Read™ Streptavidin (SA) Biosensor pins at a 10 μg/mL concentration in PBS pH7.2 for 10 minutes. A baseline was then set by washing with phosphate buffered saline (PBS, pH 7.2) for 1 minute. The association rate for the Luk17 FN3 protein was then measured by addition of a 10 ug/mL concentration in PBS (pH7.2) over a period of 10 minutes. The Luk17 FN3 protein dissociation rate was then measured following washing with PBS (pH7.2) for 5 minutes. Curve fitting to determine K D  values used the initial 60 seconds of association and dissociation steps to analyze on and off rates. 
     Results. 
     Based on Luk17 FN3/LukB crystal contacts, the Luk17 FN3 binding epitope on LukAB is minimally composed of LukB residues: Y73, W74, N191, N192, R193, K195, N206, L207, W208, W262, N263, R264, H265, G266, F267, Y270 of SEQ ID NO: 11 ( FIG. 21D ).  FIGS. 22A and 22B , respectively, show the calculated affinity (K D ) and dissociation (K dis ) constants for a series of LukAB variants in which LukB epitope residues were mutated to either X or Y with residue numbering consistent with the LukAB structure from pdb ID 4tw1 (Badarau et al., “Structure-Function Analysis of Heterodimer Formation, Oligomerization, and Receptor Binding of the  Staphylococcus aureus  Bi-component Toxin LukGH,”  J. Biol. Chem.  290, 142-156 (2015), which is hereby incorporated by reference in its entirety). 
     Considering the extent of the of the Luk17 FN3/LukB interaction surface as identified in the LukAB/Luk17 FN3 (S17)/214F crystal structure (EXAMPLE 21), it was not anticipated that individual site-directed (substitution) mutants of either the LukB epitope or the Luk17 FN3 protein paratope would negate binding in total. However, it was anticipated that mutations that disrupt key paratope-epitope interactions would have a significant impact on the affinity of the interaction between LukAB and the Luk17 FN3 protein. Of the LukB site-directed mutants evaluated, Tyr73Ala, Trp74Ala, Arg264Glu and Trp268Ala were observed to have the most significant impact on Luk17 FN3 affinity (as reflected in K D  values;  FIG. 22A ) with Tyr73Ala and Arg264Glu exhibiting the most significant impact on dissociation characteristics (as reflected in K dis  values;  FIG. 22B ). 
     Summary. 
     Mutational analysis of the Luk17 FN3 (S17) protein binding characteristics of LukAB variants described herein substantiate the importance of LukB residues identified via X-ray crystallization studies of the LukAB/S17/214F ternary complex as key components of the LukAB neutralization epitope of the Luk17 FN3 (S17) protein (EXAMPLE 21). Of the LukB site-directed mutants evaluated, Tyr73Ala, Trp74Ala, Arg264Glu and Trp268Ala were observed to have the most significant impact on Luk17 FN3 affinity (as reflected in K D  values) with Tyr73Ala and Arg264Glu exhibiting the most significant impact on dissociation characteristics (as reflected in K dis  values). 
     Example 23: Mutational Mapping of LukE to Confirm the LukED Neutralization Epitope of the Luk26 FN3 Protein 
     Further to the characterization of site-directed mutants of the Luk26 FN3 protein in terms of LukE binding and LukED neutralization characteristics (EXAMPLE 4,  FIG. 4A ), herein are described equivalent studies to confirm specific Luk26 FN3/LukE interactions at the apparent paratope/epitope interface as identified by solution phase hydrogen/deuterium exchange (HDX)-Mass Spectrometry (MS) mapping (EXAMPLE 20). 
     Procedures. 
     The proteins used for the studies described herein are (i) site-directed mutant variants of a recombinant form of LukE that bears poly-histidine and streptavidin binding sequences at the amino-terminus of the LukE sequence (SEQ ID NO: 1056) and correspond to SEQ ID NOs: 1057-1076, and (ii) a variant of the Luk26 FN3 protein that bears a carboxyl-terminal poly-histidine sequence (SEQ ID NO: 1077). Recombinant LukE variants were purified by nickel affinity chromatography as soluble proteins from an  E. coli  strain expressing biotin ligase. The Luk26 FN3 protein was purified from  E. coli  by nickel affinity chromatography. 
     Determination of Affinity (K D ) and Dissociation (K dis ) Constants. 
     K D  and K dis  values for the LukED variants bearing site-directed mutations in LukE were determined by Bio-Layer Interferometry (BLI) using an Octet RED  384 instrument (forteBIO Inc.) running the basic kinetics protocol (“Biomolecular Binding Kinetics Assays on the Octet Platform”, at outlined in Application Note 14 from Pall forteBIO Corp. accessible via the ForteBIO website, which is hereby incorporated by reference in its entirety). Briefly, biotinylated LukE mutant proteins were loaded onto Dip and Read™ Streptavidin (SA) Biosensor pins at a 10 μg/mL concentration in PBS pH7.2 for 10 minutes. A baseline was then set by washing with phosphate buffered saline (PBS, pH 7.2) for 1 minute. The association rate for the Luk26 FN3 protein was then measured by addition of a 10 ug/mL concentration in PBS (pH7.2) over a period of 10 minutes. The Luk26 FN3 protein dissociation rate was then measured following washing with PBS (pH7.2) for 5 minutes. Curve fitting to determine K D  values used the initial 60 seconds of association and dissociation steps to analyze on and off rates. 
     Results. 
     Based on the LukE residues identified as potential components of the Luk26 FN3 binding epitope by HDX mapping ( FIG. 20A ) and mapping of putative LukED neutralization epitopes onto the published crystal structure of LukE ( FIG. 20B ), a series of site-directed (substitution) mutants of LukE were prepared and characterized in terms of their binding to the Luk26 FN3 protein. Specifically, LukE variants were made in the LukE peptide regions  86 TSFSDVKGSGYELT 99  and  272 LFPRTGIYAERKHNAFVNRNF 292  (as per the amino acid numbering used in PDB entry 3ROH; SEQ ID No: 1054). Considering the extent of the apparent Luk26 FN3/LukE interaction surface, it was not anticipated that individual site-directed (substitution) mutants of either the LukE epitope or the Luk26 FN3 protein paratope would negate binding in total. However, it was anticipated that mutations that disrupt key paratope-epitope interactions would have a significant impact on the affinity of the interaction between LukE and the Luk26 FN3 protein. Of the LukE site-directed mutants evaluated, mutations of residues corresponding to the peptide region  86 TSFSDVKGSGYELT 99  (as per SEQ ID NO: 1054) had the most consistent impact on Luk26 FN3 binding affinity (as reflected in lower K D  values ( FIG. 23A ) and higher K dis  values ( FIG. 23B )) with the Ser89Ala, Val91Ala, Lys92Ala, Gly93Arg, Tyr96Ala, Leu98Ala and Thr99Ala mutant variants (numbering per SEQ ID NO: 1054) all exhibiting weaker binding compared to the wild-type (parental) LukE protein ( FIGS. 23A-23B ). In addition, this apparent epitope component may be extended beyond the linear LukE region identified by HDX mapping as an Arg101Ala variant of LukE was also found to exhibit significantly weaker Luk26 FN3 binding and enhanced dissociation characteristics. In contrast, mutation of residues in the  272 LFPRTGIYAERKHNAFVNRNF 292  peptide region in general had a less significant impact on Luk26 FN3 binding ( FIGS. 23A-23B ). However, the contribution of residues from this linear LukE sequence to the Luk26 FN3 epitope is apparent through the lower binding affinity and higher dissociation rate observed for the Tyr269Ala, Phe287Ala and Arg290Ala variants of LukE. 
     Localization of the specific residues inferred from these data to represent components of the LukE binding and LukED neutralization epitope for the Luk26 FN3 were mapped on the published crystal structure of LukE (Nocadello et al., “Crystal structures of the components of the  Staphylococcus aureus  leukotoxin ED,”  Acta. Cryst. D 72: 113-120 (2016) which is hereby incorporated by reference in its entirety; PDB entry 3ROH) and are highlighted in schematic from in  FIG. 23C . Of note, the identified epitope residues are localized to structural elements of the so-called rim domain of LukE. For clarity, alignment of the recombinant LukE sequences SEQ ID NOs: 1055 and 1056 with the sequence of the LukE protein of the published LukE structure (PDB entry 3ROH; SEQ ID NO: 1054) are included in  FIG. 23C . 
     Summary. 
     Analysis of the Luk26 FN3 protein binding characteristics of the LukE variants described herein substantiate the importance of key residues in the rim domain of LukE in forming the LukE binding and LukED neutralization epitope for the Luk26 FN3 protein. Specifically, residues Ser89, Val91, Lys92, Gly93Arg, Tyr96, Leu98 and Thr99, Tyr269, Phe287 and Arg290 of SEQ ID NO: 1054 define a minimal epitope for the Luk26 FN3 protein. As the rim domains of leukotoxins are thought to be important for interaction with the lipid bilayer of target cell membranes and for interaction with specific target cell membrane-bound receptors, it is possible that the binding of the Luk26 FN3 protein to LukE perturbs either receptor engagement, membrane binding and/or the formation of LukED heterodimers and/or higher oligomers at the surface of the membrane. In the case of LukED, Luk26 FN3 protein mediate blocking of receptor engagement could occur via perturbation of interaction with the Duffy antigen receptor for chemokines (DARC) on red blood and endothelial cells (Spaan et al., “ Staphylococcus aureus  Targets the Duffy Antigen Receptor for Chemokines (DARC) to Lyse Erythrocytes,”  Cell Host Microbe  18(3):363-70 (2015), which is hereby incorporated by reference in its entirety) or via perturbation of interactions with the chemokine receptors CXCR1 and CXCR2 on neutrophils (Spaan et al., “ Staphylococcus aureus  Leukotoxin ED Targets the Chemokine Receptors CXCR1 and CXCR2 to Kill Leukocytes and Promote Infection,”  Cell Host Microbe  14(4): 453-459 (2013), which is hereby incorporated by reference in its entirety). 
     Example 24: Definition of a Further Minimal Epitope for mAb 5133 and Characterization of the Interaction of mAb 5133 with N-Acetyl-D-Glucosamine as Determined by X-Ray Crystallography 
     The specificity of mAb 5133 for glycosylated forms of recombinant variants of the  S. aureus  SdrC protein, a member of the Serine-Aspartate Repeat (SDR) family, was demonstrated in WO2015089073 to Torres et al., which is hereby incorporated by reference in its entirety. Specifically, following incubation of purified, recombinant SdrC proteins with whole cell lysates prepared from  S. aureus  strain JE2 (Fey et al., “A Genetic Resource for Rapid and Comprehensive Phenotype Screening of Nonessential  Staphylococcus aureus  Genes”,  mBio  Volume 4 Issue 1 e00537-12 (2013), which is hereby incorporated by reference in its entirety), specific protein bands were detected via western blot in contrast to those detected following incubation with lysates prepared from  S. aureus  NE105, an otherwise-isogenic derivative of JE2 that lacks expression of the SdgB glycosyltransferase (see WO2015089073 at EXAMPLE 14, which is hereby incorporate by reference in its entirety). Further, incubation of purified, recombinant SdrC proteins with a recombinant form of the SdgB glycosyltransferase similarly yielded the mAb 5133 specific epitope in a manner that was dependent on the presence of uridine diphosphate N-acetylglucosamine (UDP-GlcNac) (PCT/US2014/069347; EXAMPLE 15). 
     In EXAMPLE 1 herein, the minimal epitope for mAb 5133 was further defined through studies of mAb5133 binding to a synthetic peptide in the presence or absence of in vitro glycosylation with recombinant  S. aureus  SdgB glycosyltransferase which indicated that (i) that the epitope target of mAb 5133 and mAb 5133-FN3 fusion proteins can be defined minimally as a peptide sequence containing as few as ten copies of the SD repeat sequence that has been modified by the  S. aureus  SdgB glycosyltransferase in the presence of UDP-GlcNac, and (ii) that no other sequences from the SdrC protein, or other  S. aureus  SDR family members [Clumping Factor A (ClfA), Clumping Factor B (ClfB), SdrD or SdrE], are necessary components of the minimal antigen epitope recognized by mAb 5133. 
     As demonstrated herein, that a minimal epitope for mAb 5133 can be further defined as a single GlcNac modified Serine residue in the context of a peptide comprised often SD repeat units. Further, specifics of the interaction of mAb 5133 with the GlcNac moiety are apparent from a high-resolution structure of the variable region of mAb 5133 determined in the presence of GlcNac. 
     Procedures. 
     Peptides, Proteins &amp; Reagents. 
     For peptide studies, a series of twenty eight (28) residue peptides were synthesized and purified (New England Peptide, Inc., Gardner, Mass.) with the following sequences: 
     
       
         
           
               
            
               
                 (i) 
               
               
                 (SEQ ID NO: 670) 
               
               
                 (N)-LC-Biotin-SDSDSDSDSDSDSDSDSDSDHHHHHHHH-(C) 
               
               
                   
               
               
                 referred to herein as the ‘SD peptide’; 
               
               
                   
               
               
                 (ii) 
               
               
                 (SEQ ID NO: 1084) 
               
               
                 (N)-LC-Biotin-TDTDTDTDTDTDTDTDTDTDHHHHHHHH-(C) 
               
               
                   
               
               
                 referred to herein as the ‘TD peptide’; 
               
               
                   
               
               
                 (iii) 
               
               
                 (SEQ ID NO: 1085) 
               
               
                 (N)-LC-Biotin-SDSDSDSDSDSDSDSDSDS GlcNac DHHHHHHHH- 
               
               
                   
               
               
                 (C) referred to herein as the ‘SD-GlcNac peptide’. 
               
            
           
         
       
     
     Each peptide bears an eight residue poly-Histidine sequence and is additionally modified with an amino-terminal biotin moiety attached via a long chain (LC) linker. The ‘SD-GlcNac peptide’ was synthesized with a single GlcNac introduced on the carboxyl-terminal serine residue. 
     For in vitro glycosylation reactions, 100 g of either peptide was incubated with 4 μg of recombinant SdgB protein in 100 μL of 100 mM Tris pH 7.5 containing 10% glycerol and 30 μg of uridine diphosphate N-acetylglucosamine (UDP-GlcNac) at 37 C° for 1 hour. Analysis of the extent of in vitro glycosylation was determined by matrix-assisted laser desorption/ionization (MALDI) analysis. The binding of mAb 5133 to the SD, TD and SD-GlcNAc peptides (+/− in vitro SdgB mediated glycosylation) was determined using a plate-based ELISA format wherein the biotinylated peptides were captured on high binding 96-well ELISA plates (Nunc) coated with streptavidin at 5 μg/mL in PBS and incubated overnight at 4° C. Detection of bound test articles was performed using an HRP-conjugated F(ab′)2 fragment donkey anti-human IgG (H+L) (Jackson Immunoresearch 709-006-149 lot 112932) and detection of streptavidin plate-bound SD peptide (+/− glycosylation) by use of an HRP-conjugated anti-polyhistidine antibody (R&amp;D Systems MAB050H polyhistidine HRP MAb Clone AD1.1.10). POD Chemiluminescence substrate (Roche-cat#11582950001) was then added to the plates and absorbance was read immediately on the Perkin Elmer EnVision Multilabel Reader at 405 nm. The data were analyzed using GraphPad Prism. Values were transformed to a log scale and fit using a non-linear regression sigmoidal dose-response equation resulting in an eleven point binding curve for each antibody against the SD peptides (+/− glycosylation) antigen. 
     A recombinant form of the SdgB glycosyltransferase (SEQ ID NO: 99) was purified as described in EXAMPLE 1. SM1B229 (SEQ ID NOs: 1082 HC and 1083 LC; construct 36 in Table 1), a Fab variant of mAb 5133, was produced by transient expression in HEK 293 cells, and purified by Ni-affinity chromatography, SEC, and ion exchange in a final buffer of 20 mM MES pH 6.5, 0.15 M NaCl. N-Acetylglucosamine (GlcNAc) was purchased from Sigma-Aldrich (Catalog number A8625). For co-crystallization, the SM1B229 Fab was mixed with concentrated GlcNAc to a final concentration of 100 mM. The final sample was 16 mg/mL SM1B229 Fab in 20 mM MES pH 6.5, 0.15 M NaCl, 100 mM GlcNAc. 
     Crystallization. 
     Crystallization screening was performed with seeding using crystal seeds of SM1B229 Fab in 20% PEG 3350, 0.1 M ammonium nitrate, 0.1 M potassium formate. 
     Data Collection and Processing. 
     A crystal was harvested from 20.2% PEG3350, 0.2 M sodium fluoride and mixed with cryo-protectant solution composed of 21.6% PEG 3350, 0.2 M sodium fluoride, 20% glycerol. The crystal was flash-cooled in liquid nitrogen. The SM1B229+GlcNAc X-ray diffraction data were collected at the Advanced Photon Source (APS, Argonne National Laboratory on beamline IMCA-CAT and detected with a Pilatus 6M detector. Diffraction intensities were processed with the X-ray Detector Software (XDS) software package. 
     Structure Determination and Analysis. 
     Molecular replacement was performed using Phaser (Read, “Pushing the boundaries of molecular replacement with maximum likelihood,”  Acta. Crystallogr. D. Biol. Crystallogr.  57(10): 1373-1382 (2001), which is hereby incorporated by reference in its entirety) with a search model composed of the free SM1B229 Fab structure. Refinement was carried out with Phenix (Adams et al., “Recent developments in the PHENIX software for automated crystallographic structure determination”,  J. Synchrotron Radiat.  11(1): 53-55 (2004), which is hereby incorporated by reference in its entirety) and model fitting with COOT (Emsley et al., “Coot: model-building tools for molecular graphics,”  Acta. Crystallogr. D. Biol. Crystallogr.  60(12 Pt 1): 2126-2132 (2004), which is hereby incorporated by reference in its entirety). The refinement statistics are summarized in Table 3. All graphics was generated with Pymol (Schrodinger LLC., www.pymol.org) and all other calculations were carried out in CCP4 (Collaborative Computational project 1994). The SM1B229 Fab/GlcNac co-crystal structure was solved to 2.50 Å resolution. 
     
       
         
           
               
             
               
                 TABLE 3 
               
               
                   
               
               
                 shows X-ray data statistics and refinement  
               
               
                 statistics for a structure determined for 
               
               
                 SM1B229 (a Fab variant of mAb 5133)  
               
               
                 in the presence of GlcNac 
               
               
                   
               
             
            
               
                 Data collection 
               
            
           
           
               
               
            
               
                 Content 
                 SM1B229 + GlcNAc 
               
               
                 Mother Liquor 
                 20.2% PEG3350, 0.2M NaF 
               
               
                 Cryo 
                 21.6% PEG 3350, 0.2M NaF, 20% glycerol 
               
               
                 Source/Detector 
                 APS IMCA-CAT/Pilatus 6M 
               
               
                 Wavelength (Å) 
                 1.000 
               
               
                 Temperature (K) 
                 100 
               
               
                 Distance (mm) 
                 300 
               
               
                 Total rotation (°) 
                 180 
               
               
                 Exp (sec)/0.5° 
                 0.50 
               
               
                 Space group 
                 P1 
               
               
                 Unit cell axes (Å) 
                 78.19, 81.42, 89.82 
               
               
                 Unit cell angles (°) 
                 84.422, 66.391, 69.181 
               
               
                 Molecules/asym. unit 
                 4 
               
               
                 V m  (Å 3 /Da)/solv. (%) 
                 2.45/50 
               
            
           
           
               
               
               
            
               
                 Resolution (Å) 
                 50-2.47 
                 (2.53-2.47) 
               
               
                 No. measured reflections 
                 76613 
                 (2518) 
               
               
                 No. unique reflections 
                 49804 
                 (1746) 
               
               
                 Completeness (%) 
                 72.9 
                 (34.5) 
               
               
                 Redundancy 
                 1.54 
                 (1.44) 
               
               
                 R-merge 
                 7.6 
                 59.6 
               
            
           
           
               
               
            
               
                 R p.i.m.   
                 0.076 
               
            
           
           
               
               
               
            
               
                 &lt;I/σ&gt; (avg) 
                 7.05 
                 (1.10) 
               
            
           
           
               
               
            
               
                 B-factor (Wilson) (Å 2 ) 
                 39.05 
               
            
           
           
               
            
               
                 Structure Refinement 
               
            
           
           
               
               
               
            
               
                 Resolution (Å) 
                 41.10-2.50 
                 (2.56-2.50) 
               
               
                 No. reflections in refinement 
                 47751 
                 (4651) 
               
            
           
           
               
               
            
               
                 Number of atoms 
                 13353 
               
               
                 Number of solvent atoms 
                 331 
               
            
           
           
               
               
               
            
               
                 Re cryst  (%) 
                 21.49 
                 (31.17) 
               
               
                 R free  (%) 
                 28.40 
                 (37.08) 
               
            
           
           
               
               
            
               
                 RMSD bond lengths (Å) 
                 0.01 
               
               
                 RMSD bond angles (°) 
                 1.318 
               
               
                 Mean B factors (Å 2 ) 
                 41.61 
               
               
                 Ramachandran plot 
                   
               
               
                 Favored (%) 
                 96.8 
               
               
                 Allowed (%) 
                 2.9 
               
               
                 Outliers (%) 
                 0.3 
               
               
                   
               
            
           
         
       
     
     Results. 
     To further define a minimal epitope for mAb 5133, a series of synthetic peptides with or without in vitro glycosylation with the SdgB glycosyltransferase were employed. As is shown in  FIG. 24A , no mAb 5133 binding is apparent with the SD peptide in the absence of glycosylation. In contrast, potent binding is observed following in vitro modification with the SdgB glycosyltransferase in the presence of UDP-GlcNac. As expected, no binding of mAb 5133 is apparent with either the TD peptide with or without prior treatment with SdgB and no glycosylation of the TD peptide was apparent via MALDI analysis. These data substantiate the specificity of the SdgB glycosyltransferase in appending GlcNac specifically to the serine residues of SD repeat peptides or proteins. Finally, the chemical introduction of a single GlcNac moiety on the carboxyl-terminal Serine residue of the ‘SD-GlcNac’ peptide was observed to create a binding epitope for mAb 5133 with an apparent binding affinity approximately ˜400-fold weaker than that observed with the SdgB-modified SD peptide. 
     The X-ray crystal structure of SM1B229 (a Fab variant of mAb 5133) in complex with N-Acetylglucosamine (GlcNAc) was determined at 2.50 Å resolution. Table 3 shows the X-ray data statistics and refinement statistics for a structure determined for SM1B229 (a Fab variant of mAb 5133) in the presence of GlcNac. There are four molecules per asymmetric unit (heavy chain ID&#39;s: H, A, C, E; light chain ID&#39;s: L, B, D, F). GlcNAc was found only in two copies: HL and AB, where the GlcNAc molecule binds to chain H and chain A. The variable regions of HL and AB superimpose with rmsd=0.27 and GlcNAc is in the same orientation for both copies. Structural analysis was performed with copy AB. As is shown in  FIG. 24B , GlcNAc is positioned in the binding pocket formed by residues R98-H109 of the H3-CDR (F). Binding to GlcNAc is mediated by hydrogen bonding interactions from side-chain hydroxyl groups of T103 and Y106 and main-chain hydrogen bonding from G100, Y105, and Y106. There is also a stacking interaction between Y106 and the glucopyranosyl ring of GlcNAc ( FIG. 24B-24C ). The light chain is not involved in the interaction. 
     GlcNAc modification of serine residues creates an antigen that is predicted to be highly polar and acidic. The electrostatic surface potential of SM1B229 reveals a basic pocket that is formed by CDR-H3, composed of the amino acids indicated in the variable heavy region sequence shown in  FIG. 24C  (see bold and underlined sequence). Tyr32(VH) and Tyr91(VL) line and complete the pocket. In addition to the identified binding site for GlcNAc, the surrounding basic CDR-H3 (Arg and/or His) residues that line the pocket likely interact with the acidic aspartate residue(s) of the SDR protein. 
     Summary. 
     The studies described herein further define a minimal binding epitope for mAb 5133 as a single GlcNac modified serine residue in the context of an SD repeat sequence. The structure of SM1B229 (a Fab variant of mAb 5133) in complex with GlcNAc reveals unique interactions with features of the GlcNac moiety. Finally, inspection of the antigen binding pocket reveals residues that are predicted to engage the acidic aspartate residues of the antigen and implies that multiple Ser GlcNaC Asp units may be accommodated. 
     Example 25: Characterization of Fibronectin Type III (FN3) Domains that Bind Alpha Hemolysin (Hla) of  Staphylococcus aureus    
     Herein is described the characterization of fibronectin type III (FN3) domain variants which bind the alpha hemolysin (Hla) protein of  Staphylococcus aureus.    
     Procedures. 
     Protein Reagents. 
     Test articles included in these studies included recombinant, purified polyhistidine-tagged versions of Luk967 (SEQ ID NO: 1097), Luk969 (SEQ ID NO: 1099), Luk982 (SEQ ID NO: 1112), Luk1012 (SEQ ID NO: 1142), Luk970 (SEQ ID NO: 1100) that were selected as Hla binders and the parental control FN3 binding domain protein TENCON parent (SEQ ID NO: 1241); all were purified from  E coli  using standard methods by nickel affinity chromatography. A poly-histidine tagged variant of a toxoid (H35L) form of Hla (Menzies et al., “Site-directed mutagenesis of the alpha-toxin gene of  Staphylococcus aureus : role of histidines in toxin activity in vitro and in a murine model,”  Infect. Immun.  62:1843-47 (1994), which is hereby incorporated by reference in its entirety) was purified from  E. coli  by nickel affinity chromatography and corresponds to SED ID NO: 1086. For ELISA assays, Hla H35L  was biotinylated in vitro using the SureLINK™ Chromophoric Biotin Labeling Kit (KPL, Inc.). Human serum albumin (HSA) conjugated with biotin (10-20 moles Biotin per mole of albumin) was purchased from Rockland Immunochemicals Inc. (Product #009-0633). A mouse monoclonal [8B7] specific to alpha-hemolysin was purchased from IBT Bioservices (Product #0210-001). Finally, an HRP-conjugated monoclonal antibody specific for the detection of poly-histidine sequences was purchased from R&amp;D Systems (Product #MAB050H). 
     ELISA assays. The relative binding of the FN3 domain proteins and control test articles to purified, recombinant Hla H35L  protein and HSA was determined by ELISA. Briefly, 100l of a 5 μg/mL solution of streptavidin (in PBS) was added per well of a 96 well White Maxisorp plate (Nunc-cat#436110) and incubated overnight at 4° C. Wells were then washed 3× with TBST (50 mM Tris.HCl, pH 7.4, 150 mM NaCl, 0.1% Tween 20) and blocked with 300 μL/well with StartingBlock T20 (Pierce cat#37543) and incubated 45-60 minutes at room temperature (RT). The plate was then washed 3 times with TBST and 0.2 μg of biotinylated versions of the target antigens (HSA or Hla H35L  in 100 μL) were added to each test well and the plate incubated 45-60 minutes at RT with gentle shaking. The plate was then washed 3 times with TBST. Test articles were diluted to 1 μM in StartingBlock T20 and 100 μL added to test wells and the plate incubated 45-60 minutes at RT with gentle shaking. The plate was then washed 3 times with TBST. For detection of bound FN3 domain test articles, 100 μL/well of a polyclonal anti-FN3-HRP antibody diluted 1:5000 in Starting block T20 was added and the plate incubated for 45-60 min at RT with gentle shaking. The plate was then washed 3 times with TBST. For detection of bound test articles, 100 μL/well of a peroxidase-conjugated, F(ab′)2 fragment of a goat anti-mouse IgG, FC-γ fragment specific antibody (Jackson Immuno Research product 115-036-071) diluted 1:5000 in Starting block T20 was added and the plate incubated for 45-60 min at RT with gentle shaking. The plate was then washed 3 times with TBST. To detect bound F(ab′)2 fragment of the goat anti-mouse antibody, 100 μL/well of the POD Chemiluminescence substrate (Roche-cat#11582950001) was added immediately prior to reading plates and the plates read using an Envision reader within 15 minutes of the substrate addition. 
     Results. 
       FIG. 25A  shows the relative ELISA signal detected for each of the test articles for both HSA and the Hla H35L  proteins. As expected, the FN3 domain proteins exhibit a range of apparent potency in binding the Hla H35L  protein but show minimal if any detectable binding to HSA. Specific binding of the ‘8B7’ mouse monoclonal antibody to the Hla H35L  protein is also apparent although the signal is weaker than some of the FN3 domain proteins under the conditions tested. Finally, as a control, detection of the plate-bound Hla H35L  protein is shown through detection using the anti-His monoclonal antibody. 
     Summary. 
     These data indicate that FN3 domain variants can be identified that exhibit specific binding to the  S. aureus  Hla (alpha hemolysin) protein. Based on the past characterization of related FN3 domain variants that selectively bind other toxin proteins of  S. aureus  (see WO2015089073 to Torres, which is hereby incorporated by reference in its entirety), it is anticipated that a subset of the FN3 domain variants described herein will neutralize the cytolytic activity of Hla. 
     Example 26: Characterization of Stem Domain Mutant Variants of LukAB that Retain the Neutralization Epitope of the FN3 Domain Protein Luk17 
     The so-called stem domains of the bi-component leukocidins of  S. aureus  are a key structural element necessary for the formation of the active oligomeric, pore forms of the toxins that pierce the host cell membrane and trigger cell death via osmotic lysis. Examination of the amino acid sequences of the  S. aureus  LukE and LukD sequences previously revealed glycine-rich motifs that localize to the stem domains of the monomer subunits of each leukocidin and leukocidin variants bearing in-frame deletions in these sequences and those of related leukocidins were found to be both inactive as toxins and exhibited a dominant-negative phenotype (Reyes-Robles et al., “Exploiting dominant-negative toxins to combat  Staphylococcus aureus  pathogenesis,”  EMBO Reports  17(3): 428-40 (2016), which is hereby incorporated by reference in its entirety). Determination of a heterodimeric structure of LukAB in a pre-pore conformation (see EXAMPLE 21) led to the design of more extensive stem loop deletion variants and their characterization is described herein. Critically it is demonstrated herein that such mutants retain the LukAB neutralization epitope recognized by the Luk17 FN3 domain protein (see EXAMPLES 21 and 22) and therein have potential utility as protein antigens in vaccine compositions. 
     Procedures. 
     Proteins &amp; Reagents. 
     Variants of LukA and LukB that bear in-frame deletions+/− insertions in the stem domain were designed and are described in Table 4. In each case, these stem mutants were created in the context of a toxoid variant of the LukAB protein (LukA E323A) (DuMont et al., “Identification of a Crucial Residue Required for  Staphylococcus aureus  LukAB Cytotoxicity and Receptor Recognition,”  Infect Immun.  82(3):1268-76 (2014), which is hereby incorporated by reference in its entirety) and were further engineered to bear poly-histidine sequences at the amino-terminus of the LukA subunit. Recombinant LukAB stem mutant proteins were purified from  E. coli  cells co-expressing each subunit and purified by nickel affinity chromatography as soluble heterodimers from  E. coli . For these studies, variants of the anti-LukAB Luk17 FN3 domain protein and the parental TENCON control FN3 domain protein were engineered that bear carboxyl-terminal extensions including both poly-histidine and streptavidin binding sequences and correspond to SEQ ID NOs: 1153 and 1152, respectively, and are herein referred to as Luk17-His-SA and TENCON-His-SA. Both proteins were purified by nickel affinity chromatography from an  E. coli  strain expressing biotin ligase. 
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 LukA and LukB Stem Domain Mutants 
               
            
           
           
               
               
               
               
               
            
               
                 SEQ ID 
                   
                   
                   
                   
               
               
                 NO: 
                 Subunit 
                 Stem Deletion* 
                 Insertion 
                 Construct Name 
               
               
                   
               
               
                 1149 
                 LukA 
                 Ser 144 -Gly 149   
                 None 
                 LukAB mut1   
               
               
                 1150 
                 LukB 
                 Gly 122 -Ser 126   
                 None 
                   
               
               
                 1149 
                 LukA 
                 Ser 144 -Gly 149   
                 None 
                 LukAB mut2   
               
               
                 1151 
                 LukB 
                 Gly 130 -Gly 134   
                 None 
                   
               
               
                 1022 
                 LukA 
                 Ser 135 -Gln 174   
                 (-SerGlyGly) 2   
                 LukAB mut3   
               
               
                 1029 
                 LukB 
                 Ser 110 -Pro 151   
                 (-SerGlyGly) 2   
               
               
                   
               
               
                 *Amino acid numbering as per PDB file 4TW1 
               
            
           
         
       
     
     Luk17 FN3 Domain Binding Studies. 
     Binding of the biotinylated variants of the Luk17-His-SA and TENCON-His-SA FN3 domain proteins to LukAB and the LukAB stem mutant variants was determined by Bio-Layer Interferometry (BLI) using an Octet RED  384 instrument (forteBIO Inc.). Briefly, the Luk17-His-SA and TENCON-His-SA proteins were loaded onto Dip and Read™ Streptavidin (SA) Biosensor pins at a 10 μg/mL concentration in PBS pH7.2 for 5 minutes. A baseline was then set by washing with phosphate buffered saline (PBS, pH 7.2) for 1 minute. Thereafter, either LukAB or stem domain LukAB variants were loaded at a 10 ug/mL concentration in PBS (pH7.2) and association measured over a period of 5 minutes. The baseline was then reset by washing with phosphate buffered saline (PBS, pH 7.2) for 1 minute. 
     Results. 
       FIG. 26A  shows the association between the Luk17-His-SA and TENCON-His-SA proteins for the LukAB toxoid protein (LukA E323A). As expected, in contrast to Luk17-His-SA, no binding is detected with the parental control FN3 domain protein TENCON-His-SA.  FIGS. 26B-26C  show the association between the Luk17-His-SA and TENCON-His-SA proteins for the LukAB mut1  and LukAB mut2  stem domain variants (DuMont et al.,  Infect Immun.  82(3): 1268-76 (2014), which is hereby incorporated by reference in its entirety) that bear targeted in-frame deletions of short glycine rich sequences in the stem domains of both LukA and LukB (Table 4). In each case, binding of the Luk17-His-SA protein is observed with no apparent binding of the TENCON-His-SA protein indicating that the LukAB neutralization epitope for the Luk17 FN3 protein is preserved in the LukAB mut1  and LukAB mut2  stem domain variants. 
     Similarly,  FIG. 26D  shows the association between the Luk17-His-SA and TENCON-His-SA proteins for the LukAB mut3  variant in which entire stem domains of LukA and LukB have been replaced with a short, flexible peptide insertion sequence, i.e., (SerGlyGly) 2 . This stem mutant variant and related variants (see SEQ IDs 1023, 1024, 1025, 1030, 1031 and 1032) were designed through analysis of the heterodimeric structure of LukAB in a pre-pore conformation (see EXAMPLE 21). Again, binding of the Luk17-His-SA protein is observed with no apparent binding of the TENCON-His-SA protein indicating that the LukAB neutralization epitope for the Luk17 FN3 protein is preserved in the LukAB mut3  stem domain variants. 
     Summary. 
     The studies described herein establish the potential of structure-based, designed variants of the LukAB leukotoxin as vaccine antigens. Specifically, LukAB variants that possess in-frame deletions in the loop sequences important for the formation of the active oligomeric pore forms necessary for localization in or at the host cell membrane retain a LukAB neutralization epitope for the Luk17 FN3 protein. Use of such LukAB variants as protein antigens in vaccine compositions is therein expected to elicit the generation antibodies that similarly bind and neutralize the cytolytic activity of LukAB. 
     Example 27: Anti-LukE FN3 Domain Proteins with Extended Serum Exposure Protect Mice from Lethal Doses of Leukotoxin LukED 
     FN3 domain proteins have molecular weights in the 10-11 kDa range and are rapidly cleared from the bloodstream via renal clearance as they are significantly below the glomerular filtration molecular weight cut-off of ˜70 kDa. Hence, the measured half-lives of FN3 domain proteins in serum are short (&lt;1 hour). Herein, is described the characterization of designed fusion proteins wherein the parental FN3 domain proteins are genetically fused with partner protein domains that confer the property of extending the serum exposure of the fusion proteins. In one example, the anti-LukE FN3 domain protein Luk26 is fused with an FN3 domain protein that binds serum albumin. In a second example, the anti-LukE FN3 domain protein Luk26 is fused with an FN3 domain protein that binds transferrin. In a third example, the anti-LukE FN3 domain protein Luk26 is fused with a serum albumin binding domain protein. For each example, equivalent fusion proteins were also made to the parental FN3 domain protein, TENCON. In all cases, four copies of a G 4 S linker were employed at the fusion juncture and poly-histidine sequences were added at the carboxyl terminus to facilitate purification. Serum albumin and transferrin are two of the most highly abundant proteins in the blood and it was assumed that fusion of FN3 domain proteins to high affinity binding domains for each of these serum proteins would result in extension of the residence time (and therein exposure) in the serum of the fusion proteins when compared to the parental FN3 domain proteins. 
     Procedures. 
     Test Articles. 
     Table 5 provides details of the test articles employed in the studies described herein. In all cases, proteins were purified from  E. coli  by nickel affinity chromatography using standard methods and endotoxin contaminants removed using a commercial kit (Acrodisc® Units with Mustang® E Membrane, Pall Corp.). 
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 Test Articles Deployed. 
               
            
           
           
               
               
               
               
            
               
                 SEQ ID 
                   
                   
                 MW  
               
               
                 NO: 
                 Description 
                 Abbreviation 
                 (Da) 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 1177 
                 Parental FN3 domain protein 
                 TENCON 
                 10,670 
               
               
                 1077 
                 Anti-LukE FN3 domain protein 
                 LukE26 
                 10,660 
               
               
                 1171 
                 Anti-serum albumin FN3 domain- 
                 SAFN3- 
                 21,876 
               
               
                   
                 TENCON fusion protein 
                 TENCON 
                   
               
               
                 1172 
                 Serum albumin binding domain- 
                 SABD-TENCON 
                 17,842 
               
               
                   
                 TENCON fusion protein 
                   
                   
               
               
                 1173 
                 Anti-transferrin FN3 domain- 
                 TFFN3- 
                 21,636 
               
               
                   
                 TENCON fusion protein 
                 TENCON 
                   
               
               
                 1174 
                 Anti-serum albumin FN3 domain- 
                 SAFN3-LukE26 
                 21,866 
               
               
                   
                 LukE26 fusion protein 
                   
                   
               
               
                 1175 
                 Serum albumin binding domain- 
                 SABD-LukE26 
                 17,832 
               
               
                   
                 LukE26 fusion protein 
                   
                   
               
               
                 1176 
                 Anti-transferrin FN3 domain- 
                 TFFN3- 
                 21,626 
               
               
                   
                 LukE26 fusion protein 
                 LukE26 
               
               
                   
               
            
           
         
       
     
     Detection of Test Articles in Serum. 
     Test articles were formulated in phosphate buffered saline (pH 7.2) and 500 μs of each (in a volume of 100 μL) was administered to female, 5-6 week old Swiss Webster ND4 mice via the retro-orbital (RO) route with a group of three animals employed per test article. 50 μL of blood was collected from each animal two hours post-dosing via the tail and +24 hour blood samples obtained via terminal cardiac puncture. At each time-point, the blood was collected into serum separator tubes, allowed to sit for at least 30 minutes, and then centrifuged for 5 minutes at 4500 rpm. Serum samples were then collected and frozen at −80° C. for subsequent analysis. For analysis by western blot, an aliquot of each serum sample was thawed on ice and the serum pooled for each test article for the +2 and +24 hour samples by combination of sera from each of the three animals per group. Each sample was diluted 1:10 in PBS and 2 μL loaded per lane on an SDS-PAGE gel. Separated proteins were transferred to a nitrocellulose membrane and the test articles detected by use of a fluorescently conjugated (IRDye® 680LT Infrared Dye (LICOR)) preparation of a rabbit monoclonal antibody specific for the framework of the TENCON FN3 binding domain protein and that is cross-reactive with the Luk26 FN3 domain protein. 
     LukED Neutralization Studies. 
     The FN3 domain test articles, starting at 7.2 μM, were titrated against a constant dose (LD 90 ) of purified LukED on freshly isolated human PMNs. Freshly isolated human PMNs (hPMNs, 200,000) from healthy donors were intoxicated for 1 hour in a final volume of 100 μl in RPMI+10 mM HEPES+0.1% human serum albumin. Following a 1 hour intoxication in a 37° C. CO 2  incubator, 25 μl of supernatant was carefully transferred to a new plate after spinning the plate down at 1500 RPM for 10 mins. Cell Titer reagent (Promega) was added to the remaining cells and incubated for 1.5 hours. The 25 μl of supernatant were mixed with equal amounts of CytoTox-ONE™ Assay reagent (Promega) that rapidly measures the amount of released of lactate dehydrogenase (LDH) from cells with a damaged membrane. LDH released into the culture medium was measured with a 10-minute coupled enzymatic assay that results in the conversion of resazurin into a fluorescent resorufin product. For these ex vivo neutralization experiments, purified LukED was used at a final concentration of 72.5 nM (2.5 μg/mL per subunit). 
     LukED Intoxication Studies. 
     5 week old ND4 mice were treated with 130 μl of a 138. μM normalized stock of each test article via intravenous (IV) retroorbital administration in groups of 3 mice. After an hour, mice were intoxicated with purified toxin at 6 μg per subunit of LukED (lethal dose) IV and then monitored for signs of imminent death: labored breathing, ruffled fur, and paralysis/lack of movement. Mice that survived the first intoxication were then given a second lethal dose of LukED IV approximately 4.5 hours after the first lethal dose of LukED (for a total of 24 μg in 5 hrs). Mice were monitored for the same signs of imminent death as previously described. In a further study, mice were treated with SABD-LukE26 at doses corresponding to a 1×, 10× and 100× molar ratio to the administered LukED toxin and then challenged 5, 24 and 48 hours post-dosing. 
     Results. 
       FIG. 27A  shows the analysis of serum samples from mice dosed with each of the test articles. As expected, neither the TENCON (Lanes 1) nor the LukE26 FN3 binding domain (Lanes 2) proteins were detected either +2 hours or +24 hours post administration. In contrast, each of the FN3 domain fusion proteins was detected both+2 hours and +24 hours post administration with the LukE26 fusion proteins exhibiting somewhat lower overall levels+24 hours post administration. These data indicate that fusion of either the TENCON or LukE26 FN3 binding domain proteins to either of the three protein fusion partners results in the expected increased residence time (and therein exposure) in the blood. 
       FIG. 27B  shows the relative protection of mice following administration of a lethal dose of the LukED leukocidin one hour post dosing of SAFN3-TENCON, SAFN3-LukE26 and parental FN3 domain proteins. As expected based on the test article composition and serum exposure, only protection was observed with the SAFN3-LukE26 protein. Mice protected by administration of the SAFN3-LukE26 protein were then re-challenged approximately 4.5 hours after the first LukED challenge (for a total of 24 μg in 5 hrs) and FIG.  27 C shows the relative protection of mice observed. Again, 100% protection was observed in the SAFN3-LukE26 μgroup. 
       FIG. 27D  shows the relative protection of mice following administration of a lethal dose of the LukED leukocidin one hour post dosing of SABD-TENCON, SABD-LukE26 and parental FN3 domain proteins. As expected based on the test article composition and serum exposure, only protection was observed with the SABD-LukE26 protein. Mice protected by administration of the SABD-LukE26 protein were then re-challenged approximately 4.5 hours after the first LukED challenge (for a total of 24 μg in 5 hrs) and  FIG. 27E  shows the relative protection of mice observed. Again, 100% protection was observed in the SABD-LukE26 μgroup. 
       FIG. 27F  shows the relative protection of mice following administration of a lethal dose of the LukED leukocidin one hour post dosing of TFFN3-LukE26, TFFN3-TENCON and parental FN3 domain proteins. As expected based on the test article composition and serum exposure, only protection is observed with the TFFN3-LukE26 protein. 
       FIGS. 27G-27H  shows the extent of protection of LukED-mediated hPMN cytolysis observed in the presence of the test articles as determined by LDH release ( FIG. 27G ) and ATP quantitation as a measure of viable cells ( FIG. 27H ). As expected, only protection from of LukED-mediated hPMN cytolysis is observed with the four LukE26 bearing test articles. 
     Finally,  FIG. 27I  shows the extent of protection of mice following administration of sequential lethal doses of the LukED leukocidin 5, 24 and 48 hours post dosing of SABD-Luk26 at a 1×, 10× and 100× molar ratio of SABD-Luk26 over LukED. In this study, no protection is observed on challenge with LukED 5-hours post-dosing at a 1:1 molar ratio of SABD-Luk26 and LukED. In contrast, 100% protection is observed at both 5- and 24-hours post-dosing at 10:1 and 100:1 molar ratios of SABD-Luk26:LukED and for the 100:1 dose, 100% protection is observed to extend beyond 48 hours. 
     Summary. 
     The studies described herein establish that FN3 domain proteins that bind LukE and neutralize the cytolytic activity of LukED ex vivo are able to protect mice from lethal intoxication mediated by LukED toxin if they are fused to protein domains that bind serum proteins such as to extend their serum residence time and therein exposure. In the context of the design and development of protein biologics that neutralize the cytolytic activity of bacterial toxins, a number of fusion partners can be envisaged for toxin-targeting FN3 domain proteins that should extend serum residence time and exposure including appendage to immunoglobulins via the light and/or heavy chain sequences as exemplified elsewhere in this application. 
     
       
         
           
               
             
               
                 TABLE 6 
               
             
            
               
                   
               
               
                 Nucleic Acid and Amino Acid Sequences of the Disclosure 
               
            
           
           
               
               
               
               
               
            
               
                 SEQ ID 
                   
                   
                   
                   
               
               
                 NO: 
                 Type 
                 Species 
                 Description 
                 Sequence 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 1 
                 PRT 
                 Artificial 
                 Tencon-25 
                 LPAPKNLVVSEVTEDSARLSWTAPDAAFDSFLI 
               
               
                   
                   
                   
                   
                 QYQESEKVGEAIVLTVPGSERSYDLTGLKPGTE 
               
               
                   
                   
                   
                   
                 YTVSIYGVKGGHRSNPLSAIFTT 
               
               
                   
               
               
                 2 
                 PRT 
                 Artificial 
                 Linker 
                 GGGGSGGGGSGGGGSGGGGS 
               
               
                   
               
               
                 3 
                 PRT 
                 Artificial 
                 Tencon BC loop 
                 TAPDAA 
               
               
                   
               
               
                 4 
                 PRT 
                 Artificial 
                 Tencon FG loop 
                 KGGHRSN 
               
               
                   
               
               
                 5 
                 DNA 
                 Artificial 
                 POP2222 
                 CGGCGGTTAGAACGCGGCTAC 
               
               
                   
               
               
                 6 
                 DNA 
                 Artificial 
                 POP2250 
                 CGGCGGTTAGAACGCGGCTACAATTAATAC 
               
               
                   
               
               
                 7 
                 DNA 
                 Artificial 
                 DidLigRev 
                 CATGATTACGCCAAGCTCAGAA 
               
               
                   
               
               
                 8 
                 DNA 
                 Artificial 
                 MDD40 
                 AGCCGCCGCCACCGGTTAATGGTGATGGTG 
               
               
                   
                   
                   
                   
                 ATGGTGACCACCGGTGGTGAAGATCGCAGA 
               
               
                   
                   
                   
                   
                 CAG 
               
               
                   
               
               
                 9 
                 DNA 
                 Artificial 
                 MDD62 
                 AAGAAGGAGAACCGGTATGCTGCCGGCGCC 
               
               
                   
                   
                   
                   
                 GAAAAACCTGGTTGTTTCTCGTGTTACC 
               
               
                   
               
               
                 10 
                 PRT 
                 
                   S. aureus 
                 
                 LukA 
                 HHHHHHNSAHKDSQDQNKKEHVDKSQQKD 
               
               
                   
                   
                   
                   
                 KRNVTNKDKNSTAPDDIGKNGKITKRTETVY 
               
               
                   
                   
                   
                   
                 DEKTNILQNLQFDFIDDPTYDKNVLLVKKQGS 
               
               
                   
                   
                   
                   
                 IHSNLKFESHKEEKNSNWLKYPSEYHVDFQV 
               
               
                   
                   
                   
                   
                 KRNRKTEILDQLPKNKISTAKVDSTFSYSSGG 
               
               
                   
                   
                   
                   
                 KFDSTKGIGRTSSNSYSKTISYNQQNYDTIASG 
               
               
                   
                   
                   
                   
                 KNNNWHVHWSVIANDLKYGGEVKNRNDELL 
               
               
                   
                   
                   
                   
                 FYRNTRIATVENPELSFASKYRYPALVRSGFN 
               
               
                   
                   
                   
                   
                 PEFLTYLSNEKSNEKTQFEVTYTRNQDILKNR 
               
               
                   
                   
                   
                   
                 PGIHYAPPILEKNKDGQRLIVTYEVDWKNKTV 
               
               
                   
                   
                   
                   
                 KVVDKYSDDNKPYKAG 
               
               
                   
               
               
                 11 
                 PRT 
                 
                   S. aureus 
                 
                 LukB 
                 KINSEIKQVSEKNLDGDTKMYTRTATTSDSQK 
               
               
                   
                   
                   
                   
                 NITQSLQFNFLTEPNYDKETVFIKAKGTIGSGL 
               
               
                   
                   
                   
                   
                 RILDPNGYWNSTLRWPGSYSVSIQNVDDNNN 
               
               
                   
                   
                   
                   
                 TNVTDFAPKNQDESREVKYTYGYKTGGDFSI 
               
               
                   
                   
                   
                   
                 NRGGLTGNITKESNYSETISYQQPSYRTLLDQS 
               
               
                   
                   
                   
                   
                 TSHKGVGWKVEAHLINNMGHDHTRQLTNDS 
               
               
                   
                   
                   
                   
                 DNRTKSEIFSLTRNGNLWAKDNFTPKDKMPV 
               
               
                   
                   
                   
                   
                 TVSEGFNPEFLAVMSHDKKDKGKSQFVVHYK 
               
               
                   
                   
                   
                   
                 RSMDEFKIDWNRHGFWGYWSGENHVDKKEE 
               
               
                   
                   
                   
                   
                 KLSALYEVDWKTHNVKFVKVLNDNEKK 
               
               
                   
               
               
                 12 
                 PRT 
                 
                   S. aureus 
                 
                 LukD 
                 MGSSHHHHHHSSGLVPAGSHMLAQHITPVSE 
               
               
                   
                   
                   
                   
                 KKVDDKITLYKTTATSDNDKLNISQILTFNFIK 
               
               
                   
                   
                   
                   
                 DKSYDKDTLVLKAAGNINSGYKKPNPKDYN 
               
               
                   
                   
                   
                   
                 YSQFYWGGKYNVSVSSESNDAVNVVDYAPK 
               
               
                   
                   
                   
                   
                 NQNEEFQVQQTLGYSYGGDINISNGLSGGLN 
               
               
                   
                   
                   
                   
                 GSKSFSETINYKQESYRTTIDRKTNHKSIGWG 
               
               
                   
                   
                   
                   
                 VEAHKIMNNGWGPYGRDSYDPTYGNELFLG 
               
               
                   
                   
                   
                   
                 GRQSSSNAGQNFLPTHQMPLLARGNFNPEFIS 
               
               
                   
                   
                   
                   
                 VLSHKQNDTKKSKIKVTYQREMDRYTNQWN 
               
               
                   
                   
                   
                   
                 RLHWVGNNYKNQNTVTFTSTYEVDWQNHTV 
               
               
                   
                   
                   
                   
                 KLIGTDSKETNPGV 
               
               
                   
               
               
                 13 
                 PRT 
                 
                   S. aureus 
                 
                 LukE 
                 MGSSHHHHHHSSGLVPAGSHMLNTNIENIGD 
               
               
                   
                   
                   
                   
                 GAEVIKRTEDVSSKKWGVTQNVQFDFVKDK 
               
               
                   
                   
                   
                   
                 KYNKDALIVKMQGFINSRTSFSDVKGSGYELT 
               
               
                   
                   
                   
                   
                 KRMIWPFQYNIGLTTKDPNVSLINYLPKNKIE 
               
               
                   
                   
                   
                   
                 TTDVGQTLGYNIGGNFQSAPSIGGNGSFNYSK 
               
               
                   
                   
                   
                   
                 TISYTQKSYVSEVDKQNSKSVKWGVKANEFV 
               
               
                   
                   
                   
                   
                 TPDGKKSAHDRYLFVQSPNGPTGSAREYFAP 
               
               
                   
                   
                   
                   
                 DNQLPPLVQSGFNPSFITTLSHEKGSSDTSEFEI 
               
               
                   
                   
                   
                   
                 SYGRNLDITYATLFPRTGIYAERKHNAFVNRN 
               
               
                   
                   
                   
                   
                 FVVRYEVNWKTHEIKVKGHN 
               
               
                   
               
               
                 14 
                 PRT 
                 Artificial 
                 Luk17 LukAB 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 15 
                 PRT 
                 Artificial 
                 Luk19 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYHAIHRLNHF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLAG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVLPDAFVSSNPLSAIFTT 
               
               
                   
               
               
                 16 
                 PRT 
                 Artificial 
                 Luk20 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYHAIHRLNHF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVLPDAFVSSNPLSAIFTT 
               
               
                   
               
               
                 17 
                 PRT 
                 Artificial 
                 Luk24 LukAB 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 QIGYFELWPNGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYEVFIRGVKGGLYSYPLSAIFTT 
               
               
                   
               
               
                 18 
                 PRT 
                 Artificial 
                 Luk8 LukD 
                 LPAPKNLVVSRVTEDSARLSWKRKPWAPIFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVWDHAGPKYEIESNPLSAIFTT 
               
               
                   
               
               
                 19 
                 PRT 
                 Artificial 
                 Luk9 LukD 
                 LPAPKNLVVSRVTEDSARLSWDRTYSLLNYF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVGGQHPTYESNPLSAIFTT 
               
               
                   
               
               
                 20 
                 PRT 
                 Artificial 
                 Luk10 LukD 
                 LPAPKNLVVSRVTEDSARLSWAASENAFVFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVGGKLHNQFEWLSNPLSAIFTT 
               
               
                   
               
               
                 21 
                 PRT 
                 Artificial 
                 Luk11 LukD 
                 LPAPKNLVVSRVTEDSARLSWRAKPWAPKFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVSAIKPGHTSNPLSAIFTT 
               
               
                   
               
               
                 22 
                 PRT 
                 Artificial 
                 Luk12 LukD 
                 LPAPKNLVVSRVTEDSARLSWRAKPWAPKFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVKASEKFIESNPLSAIFTT 
               
               
                   
               
               
                 23 
                 PRT 
                 Artificial 
                 Luk21 LukD 
                 LPAPKNLVVSRVTEDSARLSWVTKPWAEYFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVWDHAGPKYEIESNPLSAIFTT 
               
               
                   
               
               
                 24 
                 PRT 
                 Artificial 
                 Luk22 LukD 
                 LPAPKNLVVSRVTEDSARLSWRAKPWAPKFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYAVSIYGVKASEKFIESNPLSAIFTT 
               
               
                   
               
               
                 25 
                 PRT 
                 Artificial 
                 Luk26 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 26 
                 PRT 
                 Artificial 
                 Luk27 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFP 
               
               
                   
                   
                   
                 binding FN3 
                 IVYQEWQFYGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYLVDIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 27 
                 PRT 
                 Artificial 
                 Luk28 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIQYWEWWPPGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYGVIILGVKGGWYSNPLSAIFTT 
               
               
                   
               
               
                 28 
                 PRT 
                 Artificial 
                 Luk29 LukE 
                 LPAPKNLVVSRVTEDSARLSWDEQFVSNFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVFVPWDGFSEINYSNPLSAIFTT 
               
               
                   
               
               
                 29 
                 PRT 
                 Artificial 
                 Luk30 LukE 
                 LPAPKNLVVSRVTEDSARLSWAFNWNYFAFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVVALNTGNKKSNPLSAIFTT 
               
               
                   
               
               
                 30 
                 PRT 
                 Artificial 
                 Luk31 LukE 
                 LPAPNNLVVSRVTEDSARLSWDWDKYYTNR 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVLVRDYIRAAEWYSNPLSA 
               
               
                   
                   
                   
                   
                 IFTT 
               
               
                   
               
               
                 31 
                 PRT 
                 Artificial 
                 Luk32 LukE 
                 LPAPKNLVVSRVTEDSARLSWYHENAYLLFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVVYDLTPEKRSSNPLSAIFTT 
               
               
                   
               
               
                 32 
                 PRT 
                 Artificial 
                 Luk33 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVAFIPDEIEFSNPLSAIFTT 
               
               
                   
               
               
                 33 
                 PRT 
                 Artificial 
                 Luk34 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGPKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVVVVPHEFEFSNPLSAIFTT 
               
               
                   
               
               
                 34 
                 PRT 
                 Artificial 
                 Luk35 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVAHIPWEFEWSKPLSAIFTT 
               
               
                   
               
               
                 35 
                 PRT 
                 Artificial 
                 Luk36 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVADVPDEYEFSNPLSAIFTT 
               
               
                   
               
               
                 36 
                 PRT 
                 Artificial 
                 Luk37 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVVGWPLFIQSNPLSAIFTT 
               
               
                   
               
               
                 37 
                 PRT 
                 Artificial 
                 Luk38 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVELIYHGWLDFVFSNPLSAIFTT 
               
               
                   
               
               
                 38 
                 PRT 
                 Artificial 
                 Luk39 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVRVFYFSVEPTWFSNPLSAIFTT 
               
               
                   
               
               
                 39 
                 PRT 
                 Artificial 
                 Luk40 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVSYAGEPLLWIYSNPLSAIFTT 
               
               
                   
               
               
                 40 
                 PRT 
                 Artificial 
                 Luk41 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVSEVPYSEYWFSNPLSAIFTT 
               
               
                   
               
               
                 41 
                 PRT 
                 Artificial 
                 Luk42 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVVWGYRLTTEHSNPLSAIFTT 
               
               
                   
               
               
                 42 
                 PRT 
                 Artificial 
                 Luk43 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVNSFGRPTLNLFSNPLSAIFTT 
               
               
                   
               
               
                 43 
                 PRT 
                 Artificial 
                 Luk44 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVEWLQYYGETLFSNPLSAIFTT 
               
               
                   
               
               
                 44 
                 PRT 
                 Artificial 
                 Luk45 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVAWLTNAYEWEFSNPLSAIFTT 
               
               
                   
               
               
                 45 
                 PRT 
                 Artificial 
                 Luk46 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WIHYEESTWAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYGVVIVGVKGGLKSHPLSAIFTT 
               
               
                   
               
               
                 46 
                 PRT 
                 Artificial 
                 Luk47 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GIQYFETTESGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYVVFISGVKGGPLSWPLSAIFTT 
               
               
                   
               
               
                 47 
                 PRT 
                 Artificial 
                 Luk48 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 HIEYGEWWPTGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYGVLIVGVKGGFRSSPLSAIFTT 
               
               
                   
               
               
                 48 
                 PRT 
                 Artificial 
                 Luk49 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIVYAEHWPAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYNVTIPGVKGGKYSDPLSAIFTT 
               
               
                   
               
               
                 49 
                 PRT 
                 Artificial 
                 Luk50 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 VIPYSEWWPVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYGVYIVGVKGGTWSAPLSAIFTT 
               
               
                   
               
               
                 50 
                 PRT 
                 Artificial 
                 Luk51 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 QIHYFESEPGGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYVVFIIGVKGGWSSLPLSAIFTT 
               
               
                   
               
               
                 51 
                 PRT 
                 Artificial 
                 Luk52 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WIQYGEAQEFGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYIVFITGVKGGNKSYPLSAIFTT 
               
               
                   
               
               
                 52 
                 PRT 
                 Artificial 
                 Luk53 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFT 
               
               
                   
                   
                   
                 binding FN3 
                 IQYFEAEANGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYLVFIVGVKGGHSSLPLSAIFTT 
               
               
                   
               
               
                 53 
                 PRT 
                 Artificial 
                 Luk54 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAVFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 RIEYSEWWPIGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYGVVIAGVKGGGYSVPLSAIFTT 
               
               
                   
               
               
                 54 
                 PRT 
                 Artificial 
                 Luk55 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WIQYFESAGEGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYLVFIVGVKGGVPSYPLSAIFTT 
               
               
                   
               
               
                 55 
                 PRT 
                 Artificial 
                 Luk56 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 YIQYIELEIGEAIVLTVPGSERSYDLTGLKPGTE 
               
               
                   
                   
                   
                 domain 
                 YGVFISGVKGGWNSYPLSAIFTT 
               
               
                   
               
               
                 56 
                 PRT 
                 Artificial 
                 Luk57 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFNSF 
               
               
                   
                   
                   
                 binding FN3 
                 YIEYFEWFPAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYAVIIHGVKGGQRSTPLSAIFTT 
               
               
                   
               
               
                 57 
                 PRT 
                 Artificial 
                 Luk58 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 DIEYDESAHFGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYIVFIYGVKGGYASIPLSAIFTT 
               
               
                   
               
               
                 58 
                 PRT 
                 Artificial 
                 Luk59 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 DISYNEFAWSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYVVYIHGVKGGPTSYPLSAIFTT 
               
               
                   
               
               
                 59 
                 PRT 
                 Artificial 
                 Luk60 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 DIQYWEWWPFGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYGVIILGVKGGFRSTPLSAIFTT 
               
               
                   
               
               
                 60 
                 PRT 
                 Human 
                 CR5133 Heavy 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRDY 
               
               
                   
                   
                   
                 Chain 
                 YMTWIRQAPGKGPEWVSHISGSGSTIYYADS 
               
               
                   
                   
                   
                   
                 VRGRFTISRDNAKSSLYLQMDSLQADDTAVY 
               
               
                   
                   
                   
                   
                 YCARGGRATSYYWVHWGPGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSV 
               
               
                   
                   
                   
                   
                 VTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP 
               
               
                   
                   
                   
                   
                 KSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDT 
               
               
                   
                   
                   
                   
                 LMISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQD 
               
               
                   
                   
                   
                   
                 WLNGKEYKCKVSNKALPAPIEKTISKAKGQP 
               
               
                   
                   
                   
                   
                 REPQVYTLPPSRDELTKNQVSLTCLVKGFYPS 
               
               
                   
                   
                   
                   
                 DIAVEWESNGQPENNYKTTPPVLDSDGSFFLY 
               
               
                   
                   
                   
                   
                 SKLTVDKSRWQQGNVFSCSVMHEALHNHYT 
               
               
                   
                   
                   
                   
                 QKSLSLSPGK 
               
               
                   
               
               
                 61 
                 PRT 
                 Human 
                 CR5133 Light 
                 EIVLTQSPATLSLSPGERATLSCRASQSVSGYL 
               
               
                   
                   
                   
                 Chain 
                 GWYQQKPGQAPRLLIYGASSRATGIPDRFSGS 
               
               
                   
                   
                   
                   
                 GSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTF 
               
               
                   
                   
                   
                   
                 GGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTAS 
               
               
                   
                   
                   
                   
                 VVCLLNNFYPREAKVQWKVDNALQSGNSQE 
               
               
                   
                   
                   
                   
                 SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYA 
               
               
                   
                   
                   
                   
                 CEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 62 
                 PRT 
                 Human 
                 CR5133 PRASA 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRDY 
               
               
                   
                   
                   
                 Heavy Chain 
                 YMTWIRQAPGKGPEWVSHISGSGSTIYYADS 
               
               
                   
                   
                   
                   
                 VRGRFTISRDNAKSSLYLQMDSLQADDTAVY 
               
               
                   
                   
                   
                   
                 YCARGGRATSYYWVHWGPGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSV 
               
               
                   
                   
                   
                   
                 VTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP 
               
               
                   
                   
                   
                   
                 KSCDKTHTCPPCPAPPVAGPDVFLFPPKPKDT 
               
               
                   
                   
                   
                   
                 LMISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQD 
               
               
                   
                   
                   
                   
                 WLNGKEYKCKVSNAALPAPIAKTISKAKGQP 
               
               
                   
                   
                   
                   
                 REPQVYTLPPSRDELTKNQVSLTCLVKGFYPS 
               
               
                   
                   
                   
                   
                 DIAVEWESNGQPENNYKTTPPVLDSDGSFFLY 
               
               
                   
                   
                   
                   
                 SKLTVDKSRWQQGNVFSCSVMHEALHNHYT 
               
               
                   
                   
                   
                   
                 QKSLSLSPGK 
               
               
                   
               
               
                 63 
                 PRT 
                 Human 
                 CR5133 PRASA 
                 EIVLTQSPATLSLSPGERATLSCRASQSVSGYL 
               
               
                   
                   
                   
                 Light Chain 
                 GWYQQKPGQAPRLLIYGASSRATGIPDRFSGS 
               
               
                   
                   
                   
                   
                 GSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTF 
               
               
                   
                   
                   
                   
                 GGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTAS 
               
               
                   
                   
                   
                   
                 VVCLLNNFYPREAKVQWKVDNALQSGNSQE 
               
               
                   
                   
                   
                   
                 SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYA 
               
               
                   
                   
                   
                   
                 CEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 64 
                 PRT 
                 Human 
                 CR5133 A6 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRDY 
               
               
                   
                   
                   
                 Heavy Chain 
                 YMTWIRQAPGKGPEWVSHISGSGSTIYYADS 
               
               
                   
                   
                   
                   
                 VRGRFTISRDNAKSSLYLQMDSLQADDTAVY 
               
               
                   
                   
                   
                   
                 YCARGGRATSYYWVHWGPGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSV 
               
               
                   
                   
                   
                   
                 VTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP 
               
               
                   
                   
                   
                   
                 KSCDKTHTCPPCPAPELLGGPSVFLFPPKPKDT 
               
               
                   
                   
                   
                   
                 LMISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQD 
               
               
                   
                   
                   
                   
                 WLNGKEYKCKVSNKALPAPIEKTISKAKGQP 
               
               
                   
                   
                   
                   
                 REPQVYTLPPSRDELTKNQVSLTCLVKGFYPS 
               
               
                   
                   
                   
                   
                 DIAVEWESNGQPENNYKTTPPVLDSDGSFFLY 
               
               
                   
                   
                   
                   
                 SKLTVDKSRWQQGNVFSCSVMHEALHNRFT 
               
               
                   
                   
                   
                   
                 QKSLSLSPGK 
               
               
                   
               
               
                 65 
                 PRT 
                 Human 
                 CR5133 A6 Light 
                 EIVLTQSPATLSLSPGERATLSCRASQSVSGYL 
               
               
                   
                   
                   
                 Chain 
                 GWYQQKPGQAPRLLIYGASSRATGIPDRFSGS 
               
               
                   
                   
                   
                   
                 GSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTF 
               
               
                   
                   
                   
                   
                 GGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTAS 
               
               
                   
                   
                   
                   
                 VVCLLNNFYPREAKVQWKVDNALQSGNSQE 
               
               
                   
                   
                   
                   
                 SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYA 
               
               
                   
                   
                   
                   
                 CEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 66 
                 PRT 
                 Human 
                 CR5133 PRASA 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRDY 
               
               
                   
                   
                   
                 A6 Heavy Chain 
                 YMTWIRQAPGKGPEWVSHISGSGSTIYYADS 
               
               
                   
                   
                   
                   
                 VRGRFTISRDNAKSSLYLQMDSLQADDTAVY 
               
               
                   
                   
                   
                   
                 YCARGGRATSYYWVHWGPGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSV 
               
               
                   
                   
                   
                   
                 VTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP 
               
               
                   
                   
                   
                   
                 KSCDKTHTCPPCPAPPVAGPDVFLFPPKPKDT 
               
               
                   
                   
                   
                   
                 LMISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQD 
               
               
                   
                   
                   
                   
                 WLNGKEYKCKVSNAALPAPIAKTISKAKGQP 
               
               
                   
                   
                   
                   
                 REPQVYTLPPSRDELTKNQVSLTCLVKGFYPS 
               
               
                   
                   
                   
                   
                 DIAVEWESNGQPENNYKTTPPVLDSDGSFFLY 
               
               
                   
                   
                   
                   
                 SKLTVDKSRWQQGNVFSCSVMHEALHNRFT 
               
               
                   
                   
                   
                   
                 QKSLSLSPGK 
               
               
                   
               
               
                 67 
                 PRT 
                 Human 
                 CR5133 PRASA 
                 EIVLTQSPATLSLSPGERATLSCRASQSVSGYL 
               
               
                   
                   
                   
                 A6 Light Chain 
                 GWYQQKPGQAPRLLIYGASSRATGIPDRFSGS 
               
               
                   
                   
                   
                   
                 GSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTF 
               
               
                   
                   
                   
                   
                 GGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTAS 
               
               
                   
                   
                   
                   
                 VVCLLNNFYPREAKVQWKVDNALQSGNSQE 
               
               
                   
                   
                   
                   
                 SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYA 
               
               
                   
                   
                   
                   
                 CEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 68 
                 PRT 
                 Artificial 
                 CR5133 PRASA 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRDY 
               
               
                   
                   
                   
                 A6 LC-D Heavy 
                 YMTWIRQAPGKGPEWVSHISGSGSTIYYADS 
               
               
                   
                   
                   
                 Chain 
                 VRGRFTISRDNAKSSLYLQMDSLQADDTAVY 
               
               
                   
                   
                   
                   
                 YCARGGRATSYYWVHWGPGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSV 
               
               
                   
                   
                   
                   
                 VTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP 
               
               
                   
                   
                   
                   
                 KSCDKTHTCPPCPAPPVAGPDVFLFPPKPKDT 
               
               
                   
                   
                   
                   
                 LMISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQD 
               
               
                   
                   
                   
                   
                 WLNGKEYKCKVSNAALPAPIAKTISKAKGQP 
               
               
                   
                   
                   
                   
                 REPQVYTLPPSRDELTKNQVSLTCLVKGFYPS 
               
               
                   
                   
                   
                   
                 DIAVEWESNGQPENNYKTTPPVLDSDGSFFLY 
               
               
                   
                   
                   
                   
                 SKLTVDKSRWQQGNVFSCSVMHEALHNRFT 
               
               
                   
                   
                   
                   
                 QKSLSLSPGK 
               
               
                   
               
               
                 69 
                 PRT 
                 Artificial 
                 CR5133 PRASA 
                 EIVLTQSPATLSLSPGERATLSCRASQSVSGYL 
               
               
                   
                   
                   
                 A6 LC-D Light 
                 GWYQQKPGQAPRLLIYGASSRATGIPDRFSGS 
               
               
                   
                   
                   
                 Chain 
                 GSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTF 
               
               
                   
                   
                   
                   
                 GGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTAS 
               
               
                   
                   
                   
                   
                 VVCLLNNFYPREAKVQWKVDNALQSGNSQE 
               
               
                   
                   
                   
                   
                 SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYA 
               
               
                   
                   
                   
                   
                 CEVTHQGLSSPVTKSFNRGECGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSLPAPKNLVVSRVTEDSARLSW 
               
               
                   
                   
                   
                   
                 RAKPWAPKFDSFLIQYQESEKVGEAIVLTVPG 
               
               
                   
                   
                   
                   
                 SERSYDLTGLKPGTEYTVSIYGVKASEKFIESN 
               
               
                   
                   
                   
                   
                 PLSAIFTT 
               
               
                   
               
               
                 70 
                 PRT 
                 Artificial 
                 CR5133 PRASA 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRDY 
               
               
                   
                   
                   
                 A6 HC-AB 
                 YMTWIRQAPGKGPEWVSHISGSGSTIYYADS 
               
               
                   
                   
                   
                 Heavy Chain 
                 VRGRFTISRDNAKSSLYLQMDSLQADDTAVY 
               
               
                   
                   
                   
                   
                 YCARGGRATSYYWVHWGPGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSV 
               
               
                   
                   
                   
                   
                 VTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP 
               
               
                   
                   
                   
                   
                 KSCDKTHTCPPCPAPPVAGPDVFLFPPKPKDT 
               
               
                   
                   
                   
                   
                 LMISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQD 
               
               
                   
                   
                   
                   
                 WLNGKEYKCKVSNAALPAPIAKTISKAKGQP 
               
               
                   
                   
                   
                   
                 REPQVYTLPPSRDELTKNQVSLTCLVKGFYPS 
               
               
                   
                   
                   
                   
                 DIAVEWESNGQPENNYKTTPPVLDSDGSFFLY 
               
               
                   
                   
                   
                   
                 SKLTVDKSRWQQGNVFSCSVMHEALHNRFT 
               
               
                   
                   
                   
                   
                 QKSLSLSPGKGGGGSGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FWITYEEKFYRGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 71 
                 PRT 
                 Artificial 
                 CR5133 PRASA 
                 EIVLTQSPATLSLSPGERATLSCRASQSVSGYL 
               
               
                   
                   
                   
                 A6 HC-AB Light 
                 GWYQQKPGQAPRLLIYGASSRATGIPDRFSGS 
               
               
                   
                   
                   
                 Chain 
                 GSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTF 
               
               
                   
                   
                   
                   
                 GGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTAS 
               
               
                   
                   
                   
                   
                 VVCLLNNFYPREAKVQWKVDNALQSGNSQE 
               
               
                   
                   
                   
                   
                 SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYA 
               
               
                   
                   
                   
                   
                 CEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 72 
                 PRT 
                 Artificial 
                 CR5133 PRASA 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRDY 
               
               
                   
                   
                   
                 A6 LC-D HC-AB 
                 YMTWIRQAPGKGPEWVSHISGSGSTIYYADS 
               
               
                   
                   
                   
                 Heavy Chain 
                 VRGRFTISRDNAKSSLYLQMDSLQADDTAVY 
               
               
                   
                   
                   
                   
                 YCARGGRATSYYWVHWGPGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSV 
               
               
                   
                   
                   
                   
                 VTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP 
               
               
                   
                   
                   
                   
                 KSCDKTHTCPPCPAPPVAGPDVFLFPPKPKDT 
               
               
                   
                   
                   
                   
                 LMISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQD 
               
               
                   
                   
                   
                   
                 WLNGKEYKCKVSNAALPAPIAKTISKAKGQP 
               
               
                   
                   
                   
                   
                 REPQVYTLPPSRDELTKNQVSLTCLVKGFYPS 
               
               
                   
                   
                   
                   
                 DIAVEWESNGQPENNYKTTPPVLDSDGSFFLY 
               
               
                   
                   
                   
                   
                 SKLTVDKSRWQQGNVFSCSVMHEALHNRFT 
               
               
                   
                   
                   
                   
                 QKSLSLSPGKGGGGSGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FWITYEEKFYRGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 73 
                 PRT 
                 Artificial 
                 CR5133 PRASA 
                 EIVLTQSPATLSLSPGERATLSCRASQSVSGYL 
               
               
                   
                   
                   
                 A6 LC-D HC-AB 
                 GWYQQKPGQAPRLLIYGASSRATGIPDRFSGS 
               
               
                   
                   
                   
                 Light Chain 
                 GSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTF 
               
               
                   
                   
                   
                   
                 GGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTAS 
               
               
                   
                   
                   
                   
                 VVCLLNNFYPREAKVQWKVDNALQSGNSQE 
               
               
                   
                   
                   
                   
                 SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYA 
               
               
                   
                   
                   
                   
                 CEVTHQGLSSPVTKSFNRGECGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSLPAPKNLVVSRVTEDSARLSW 
               
               
                   
                   
                   
                   
                 RAKPWAPKFDSFLIQYQESEKVGEAIVLTVPG 
               
               
                   
                   
                   
                   
                 SERSYDLTGLKPGTEYTVSIYGVKASEKFIESN 
               
               
                   
                   
                   
                   
                 PLSAIFTT 
               
               
                   
               
               
                 74 
                 PRT 
                 Artificial 
                 CR5133 PRASA 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRDY 
               
               
                   
                   
                   
                 A6 HC-D Heavy 
                 YMTWIRQAPGKGPEWVSHISGSGSTIYYADS 
               
               
                   
                   
                   
                 Chain 
                 VRGRFTISRDNAKSSLYLQMDSLQADDTAVY 
               
               
                   
                   
                   
                   
                 YCARGGRATSYYWVHWGPGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSV 
               
               
                   
                   
                   
                   
                 VTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP 
               
               
                   
                   
                   
                   
                 KSCDKTHTCPPCPAPPVAGPDVFLFPPKPKDT 
               
               
                   
                   
                   
                   
                 LMISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQD 
               
               
                   
                   
                   
                   
                 WLNGKEYKCKVSNAALPAPIAKTISKAKGQP 
               
               
                   
                   
                   
                   
                 REPQVYTLPPSRDELTKNQVSLTCLVKGFYPS 
               
               
                   
                   
                   
                   
                 DIAVEWESNGQPENNYKTTPPVLDSDGSFFLY 
               
               
                   
                   
                   
                   
                 SKLTVDKSRWQQGNVFSCSVMHEALHNRFT 
               
               
                   
                   
                   
                   
                 QKSLSLSPGKGGGGSGGGGSGGGGSGGGGSL 
               
               
                   
                   
                   
                   
                 PAPKNLVVSRVTEDSARLSWRAKPWAPKFDS 
               
               
                   
                   
                   
                   
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYTVSIYGVKASEKFIESNPLSAIFTT 
               
               
                   
               
               
                 75 
                 PRT 
                 Artificial 
                 CR5133 PRASA 
                 EIVLTQSPATLSLSPGERATLSCRASQSVSGYL 
               
               
                   
                   
                   
                 A6 HC-D Light 
                 GWYQQKPGQAPRLLIYGASSRATGIPDRFSGS 
               
               
                   
                   
                   
                 Chain 
                 GSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTF 
               
               
                   
                   
                   
                   
                 GGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTAS 
               
               
                   
                   
                   
                   
                 VVCLLNNFYPREAKVQWKVDNALQSGNSQE 
               
               
                   
                   
                   
                   
                 SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYA 
               
               
                   
                   
                   
                   
                 CEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 76 
                 PRT 
                 Artificial 
                 CR5133 PRASA 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRDY 
               
               
                   
                   
                   
                 A6 HC AB-D 
                 YMTWIRQAPGKGPEWVSHISGSGSTIYYADS 
               
               
                   
                   
                   
                 Heavy Chain 
                 VRGRFTISRDNAKSSLYLQMDSLQADDTAVY 
               
               
                   
                   
                   
                   
                 YCARGGRATSYYWVHWGPGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSV 
               
               
                   
                   
                   
                   
                 VTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP 
               
               
                   
                   
                   
                   
                 KSCDKTHTCPPCPAPPVAGPDVFLFPPKPKDT 
               
               
                   
                   
                   
                   
                 LMISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQD 
               
               
                   
                   
                   
                   
                 WLNGKEYKCKVSNAALPAPIAKTISKAKGQP 
               
               
                   
                   
                   
                   
                 REPQVYTLPPSRDELTKNQVSLTCLVKGFYPS 
               
               
                   
                   
                   
                   
                 DIAVEWESNGQPENNYKTTPPVLDSDGSFFLY 
               
               
                   
                   
                   
                   
                 SKLTVDKSRWQQGNVFSCSVMHEALHNRFT 
               
               
                   
                   
                   
                   
                 QKSLSLSPGKGGGGSGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FWITYEEKFYRGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYKVWIVGVKGGQGSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSLPAPKNLVVSRVTED 
               
               
                   
                   
                   
                   
                 SARLSWRAKPWAPKFDSFLIQYQESEKVGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYTVSIYGVKAS 
               
               
                   
                   
                   
                   
                 EKFIESNPLSAIFTT 
               
               
                   
               
               
                 77 
                 PRT 
                 Artificial 
                 CR5133 PRASA 
                 EIVLTQSPATLSLSPGERATLSCRASQSVSGYL 
               
               
                   
                   
                   
                 A6 HC AB-D 
                 GWYQQKPGQAPRLLIYGASSRATGIPDRFSGS 
               
               
                   
                   
                   
                 Light Chain 
                 GSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTF 
               
               
                   
                   
                   
                   
                 GGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTAS 
               
               
                   
                   
                   
                   
                 VVCLLNNFYPREAKVQWKVDNALQSGNSQE 
               
               
                   
                   
                   
                   
                 SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYA 
               
               
                   
                   
                   
                   
                 CEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 78 
                 PRT 
                 Artificial 
                 CR5133 PRASA 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRDY 
               
               
                   
                   
                   
                 A6 HC D-AB 
                 YMTWIRQAPGKGPEWVSHISGSGSTIYYADS 
               
               
                   
                   
                   
                 Heavy Chain 
                 VRGRFTISRDNAKSSLYLQMDSLQADDTAVY 
               
               
                   
                   
                   
                   
                 YCARGGRATSYYWVHWGPGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSV 
               
               
                   
                   
                   
                   
                 VTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP 
               
               
                   
                   
                   
                   
                 KSCDKTHTCPPCPAPPVAGPDVFLFPPKPKDT 
               
               
                   
                   
                   
                   
                 LMISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQD 
               
               
                   
                   
                   
                   
                 WLNGKEYKCKVSNAALPAPIAKTISKAKGQP 
               
               
                   
                   
                   
                   
                 REPQVYTLPPSRDELTKNQVSLTCLVKGFYPS 
               
               
                   
                   
                   
                   
                 DIAVEWESNGQPENNYKTTPPVLDSDGSFFLY 
               
               
                   
                   
                   
                   
                 SKLTVDKSRWQQGNVFSCSVMHEALHNRFT 
               
               
                   
                   
                   
                   
                 QKSLSLSPGKGGGGSGGGGSGGGGSGGGGSL 
               
               
                   
                   
                   
                   
                 PAPKNLVVSRVTEDSARLSWRAKPWAPKFDS 
               
               
                   
                   
                   
                   
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYTVSIYGVKASEKFIESNPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFWITYEEKFYRGEAIV 
               
               
                   
                   
                   
                   
                 LTVPGSERSYDLTGLKPGTEYKVWIVGVKGG 
               
               
                   
                   
                   
                   
                 QGSWPLSAIFTT 
               
               
                   
               
               
                 79 
                 PRT 
                 Artificial 
                 CR5133 PRASA 
                 EIVLTQSPATLSLSPGERATLSCRASQSVSGYL 
               
               
                   
                   
                   
                 A6 HC D-AB 
                 GWYQQKPGQAPRLLIYGASSRATGIPDRFSGS 
               
               
                   
                   
                   
                 Light Chain 
                 GSGTDFTLTISRLEPEDFAVYYCQQYGSSPLTF 
               
               
                   
                   
                   
                   
                 GGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTAS 
               
               
                   
                   
                   
                   
                 VVCLLNNFYPREAKVQWKVDNALQSGNSQE 
               
               
                   
                   
                   
                   
                 SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYA 
               
               
                   
                   
                   
                   
                 CEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 80 
                 DNA 
                 Artificial 
                 BC6 
                 GTGACACGGCGGTTAGAACGCGGCTACAAT 
               
               
                   
                   
                   
                   
                 TAATACATAACCCCATCCCCCTGTTGACAAT 
               
               
                   
                   
                   
                   
                 TAATCATCGGCTCGTATAATGTGTGGAATTG 
               
               
                   
                   
                   
                   
                 TGAGCGGATAACAATTTCACACAGGAAACA 
               
               
                   
                   
                   
                   
                 GGATCTACCATGCTGCCGGCGCCGAAAAAC 
               
               
                   
                   
                   
                   
                 CTGGTTGTTTCTGAAGTTACCGAAGACTCTC 
               
               
                   
                   
                   
                   
                 TGCGTCTGTCTTGGNNNNNNNNNNNNNNNN 
               
               
                   
                   
                   
                   
                 NNTTYGACTCTTTCCTGATCCAGTACCAGGA 
               
               
                   
                   
                   
                   
                 ATCTGAAAAAGTTGGTGAAGCGATCAACCT 
               
               
                   
                   
                   
                   
                 GACCGTTCCGGGTTCTGAACGTTCTTACGAC 
               
               
                   
                   
                   
                   
                 CTGACCGGTCTGAAACCGGGTACCGAATAC 
               
               
                   
                   
                   
                   
                 ACCGTTTCTATCTACGGTGTTCTTAGAAGCT 
               
               
                   
                   
                   
                   
                 TCCCAAAGGC 
               
               
                   
               
               
                 81 
                 DNA 
                 Artificial 
                 BC7 
                 GTGACACGGCGGTTAGAACGCGGCTACAAT 
               
               
                   
                   
                   
                   
                 TAATACATAACCCCATCCCCCTGTTGACAAT 
               
               
                   
                   
                   
                   
                 TAATCATCGGCTCGTATAATGTGTGGAATTG 
               
               
                   
                   
                   
                   
                 TGAGCGGATAACAATTTCACACAGGAAACA 
               
               
                   
                   
                   
                   
                 GGATCTACCATGCTGCCGGCGCCGAAAAAC 
               
               
                   
                   
                   
                   
                 CTGGTTGTTTCTGAAGTTACCGAAGACTCTC 
               
               
                   
                   
                   
                   
                 TGCGTCTGTCTTGGNNNNNNNNNNNNNNNN 
               
               
                   
                   
                   
                   
                 NNNNNTTYGACTCTTTCCTGATCCAGTACCA 
               
               
                   
                   
                   
                   
                 GGAATCTGAAAAAGTTGGTGAAGCGATCAA 
               
               
                   
                   
                   
                   
                 CCTGACCGTTCCGGGTTCTGAACGTTCTTAC 
               
               
                   
                   
                   
                   
                 GACCTGACCGGTCTGAAACCGGGTACCGAA 
               
               
                   
                   
                   
                   
                 TACACCGTTTCTATCTACGGTGTTCTTAGAA 
               
               
                   
                   
                   
                   
                 GCTTCCCAAAGGC 
               
               
                   
               
               
                 82 
                 DNA 
                 Artificial 
                 BC8 
                 GTGACACGGCGGTTAGAACGCGGCTACAAT 
               
               
                   
                   
                   
                   
                 TAATACATAACCCCATCCCCCTGTTGACAAT 
               
               
                   
                   
                   
                   
                 TAATCATCGGCTCGTATAATGTGTGGAATTG 
               
               
                   
                   
                   
                   
                 TGAGCGGATAACAATTTCACACAGGAAACA 
               
               
                   
                   
                   
                   
                 GGATCTACCATGCTGCCGGCGCCGAAAAAC 
               
               
                   
                   
                   
                   
                 CTGGTTGTTTCTGAAGTTACCGAAGACTCTC 
               
               
                   
                   
                   
                   
                 TGCGTCTGTCTTGGNNNNNNNNNNNNNNNN 
               
               
                   
                   
                   
                   
                 NNNNNNNNTTYGACTCTTTCCTGATCCAGT 
               
               
                   
                   
                   
                   
                 ACCAGGAATCTGAAAAAGTTGGTGAAGCGA 
               
               
                   
                   
                   
                   
                 TCAACCTGACCGTTCCGGGTTCTGAACGTTC 
               
               
                   
                   
                   
                   
                 TTACGACCTGACCGGTCTGAAACCGGGTAC 
               
               
                   
                   
                   
                   
                 CGAATACACCGTTTCTATCTACGGTGTTCTT 
               
               
                   
                   
                   
                   
                 AGAAGCTTCCCAAAGGC 
               
               
                   
               
               
                 83 
                 DNA 
                 Artificial 
                 BC9 
                 GTGACACGGCGGTTAGAACGCGGCTACAAT 
               
               
                   
                   
                   
                   
                 TAATACATAACCCCATCCCCCTGTTGACAAT 
               
               
                   
                   
                   
                   
                 TAATCATCGGCTCGTATAATGTGTGGAATTG 
               
               
                   
                   
                   
                   
                 TGAGCGGATAACAATTTCACACAGGAAACA 
               
               
                   
                   
                   
                   
                 GGATCTACCATGCTGCCGGCGCCGAAAAAC 
               
               
                   
                   
                   
                   
                 CTGGTTGTTTCTGAAGTTACCGAAGACTCTC 
               
               
                   
                   
                   
                   
                 TGCGTCTGTCTTGGNNNNNNNNNNNNNNNN 
               
               
                   
                   
                   
                   
                 NNNNNNNNNNNTTYGACTCTTTCCTGATCC 
               
               
                   
                   
                   
                   
                 AGTACCAGGAATCTGAAAAAGTTGGTGAAG 
               
               
                   
                   
                   
                   
                 CGATCAACCTGACCGTTCCGGGTTCTGAAC 
               
               
                   
                   
                   
                   
                 GTTCTTACGACCTGACCGGTCTGAAACCGG 
               
               
                   
                   
                   
                   
                 GTACCGAATACACCGTTTCTATCTACGGTGT 
               
               
                   
                   
                   
                   
                 TCTTAGAAGCTTCCCAAAGGC 
               
               
                   
               
               
                 84 
                 DNA 
                 Artificial 
                 130mer-L17A 
                 CGGCGGTTAGAACGCGGCTACAATTAATAC 
               
               
                   
                   
                   
                   
                 ATAACCCCATCCCCCTGTTGACAATTAATCA 
               
               
                   
                   
                   
                   
                 TCGGCTCGTATAATGTGTGGAATTGTGAGC 
               
               
                   
                   
                   
                   
                 GGATAACAATTTCACACAGGAAACAGGATC 
               
               
                   
                   
                   
                   
                 TACCATGCTG 
               
               
                   
               
               
                 85 
                 DNA 
                 Artificial 
                 POP2222ext 
                 CGG CGG TTA GAA CGC GGC TAC AAT TAA 
               
               
                   
                   
                   
                   
                 TAC 
               
               
                   
               
               
                 86 
                 DNA 
                 Artificial 
                 LS1114 
                 CCA AGA CAG ACG GGC AGA GTC TTC GGT 
               
               
                   
                   
                   
                   
                 AAC GCG AGA AAC AAC CAG GTT TTT CGG 
               
               
                   
                   
                   
                   
                 CGC CGG CAG CAT GGT AGA TCC TGT TTC 
               
               
                   
               
               
                 87 
                 DNA 
                 Artificial 
                 LS1115 
                 CCG AAG ACT CTG CCC GTC TGT CTT GG 
               
               
                   
               
               
                 88 
                 DNA 
                 Artificial 
                 LS1117 
                 CAG TGG TCT CAC GGA TTC CTG GTA CTG 
               
               
                   
                   
                   
                   
                 GAT CAG GAA AGA GTC GAA 
               
               
                   
               
               
                 89 
                 DNA 
                 Artificial 
                 SDG10 
                 CATGCGGTCTCTTCCGAAAAAGTTGGTGAA 
               
               
                   
                   
                   
                   
                 GCGATCGTCCTGACCGTTCCGGGT 
               
               
                   
               
               
                 90 
                 DNA 
                 Artificial 
                 SDG24 
                 GGTGGTGAAGATCGCAGACAGCGGGTTAG 
               
               
                   
               
               
                 91 
                 DNA 
                 Artificial 
                 SDG28 
                 AAGATCAGTTGCGGCCGCTAGACTAGAACC 
               
               
                   
                   
                   
                   
                 GCTGCCACCGCCGGTGGTGAAGATCGCAGAC 
               
               
                   
               
               
                 92 
                 PRT 
                 Artificial 
                 TCL19 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF X I 
               
               
                   
                   
                   
                   
                   X Y X E XXXX GEAIVLTVPGSERSYDLTGLKPGTE 
               
               
                   
                   
                   
                   
                 Y X V X I X GVKGG XX S X PLSAIFTT; 
               
               
                   
                   
                   
                   
                 wherein “X” is an equal mixture of 18 amino acids (no 
               
               
                   
                   
                   
                   
                 cysteine or methionine) 
               
               
                   
               
               
                 93 
                 PRT 
                 Artificial 
                 TCL19 C strand 
                 DSFXIXYXE, wherein “X” is an equal mixture of 18 
               
               
                   
                   
                   
                   
                 acids (no cysteine or methionine) 
               
               
                   
               
               
                 94 
                 PRT 
                 Artificial 
                 TCL19 F strand 
                 TEYXVXIXGV, wherein “X” is an equal mixture 
               
               
                   
                   
                   
                   
                 of 18 amino acids (no cysteine or methionine) 
               
               
                   
               
               
                 95 
                 PRT 
                 Artificial 
                 TCL19 C strand + 
                 DSFXIXYXEXXXXGE, wherein “X” is an equal 
               
               
                   
                   
                   
                 CD loop 
                 mixture of 18 amino acids (no cysteine or 
               
               
                   
                   
                   
                   
                 methionine) 
               
               
                   
               
               
                 96 
                 PRT 
                 Artificial 
                 TCL19 F strand + 
                 TEYXVXIXGVKGGXXSX, wherein “X” is an 
               
               
                   
                   
                   
                 FG loop 
                 equal mixture of 18 amino acids (no cysteine or 
               
               
                   
                   
                   
                   
                 methionine) 
               
               
                   
               
               
                 97 
                 PRT 
                 Artificial 
                 TCL19 A strand + 
                 LPAPKXLXVXXVXXXXAXLXWXAPDAAF, 
               
               
                   
                   
                   
                 AB loop + B 
                 wherein “X” is an equal mixture of 18 amino acids 
               
               
                   
                   
                   
                 strand + BC loop 
                 (no cysteine or methionine) 
               
               
                   
               
               
                 98 
                 PRT 
                 Artificial 
                 TCL19 E strand 
                 XYXLT, wherein “X” is an equal mixture of 18 
               
               
                   
                   
                   
                   
                 amino acids (no cysteine or methionine) 
               
               
                   
               
               
                 99 
                 PRT 
                 
                   S. aureus 
                 
                 SdgB 
                 MKETAAAKFERQHMDSPDLGTLVPRGSMA 
               
               
                   
                   
                   
                 glycosyltransferase 
                 MNYFVGNSLGVNLTGIEKAIINRLNLFKEMG 
               
               
                   
                   
                   
                   
                 RPAQCVFLSWNRYLYRNAQNYITSSDYINMY 
               
               
                   
                   
                   
                   
                 DFFQEATYLERNEPFDWLSYWTDECHYTLK 
               
               
                   
                   
                   
                   
                 HVENSHDFRIYDQERFLMYAHFQDPKYRILD 
               
               
                   
                   
                   
                   
                 YVNHFDSQRRKVKRDFYDVRGFLSCSRILVD 
               
               
                   
                   
                   
                   
                 KQQTLCEFFYNPEDDTKLEKYFSYKDGKPEV 
               
               
                   
                   
                   
                   
                 QKIIVYYANKQYFFNNETELGAFFIKQLYQH 
               
               
                   
                   
                   
                   
                 GDLFFSDRNVYTAPIFNLTPESIPVVAVLHST 
               
               
                   
                   
                   
                   
                 HIKNIDALDSSPFKNVYKAMFENLSRYRAIIV 
               
               
                   
                   
                   
                   
                 STEQQKLDVEKRINHTIPVVNIPVGYSETIDTP 
               
               
                   
                   
                   
                   
                 VQTLDQRSVKLISVARYSPEKQLHQQIELIKR 
               
               
                   
                   
                   
                   
                 LVSYVPKIELHMYGFGSESKKLNELIQKYGLE 
               
               
                   
                   
                   
                   
                 NHVYLRGFLSNLDQEYSDAYLSLITSNMEGF 
               
               
                   
                   
                   
                   
                 SLALLESLAHGVPVISYDIKYGPNELITSDFNG 
               
               
                   
                   
                   
                   
                 YLITKNDEDALFDKVKYVIDHPEVQQRLSKG 
               
               
                   
                   
                   
                   
                 SLAKAQQYSKASLIKQWDQFVRLILEHHHHHH 
               
               
                   
               
               
                 100 
                 PRT 
                 
                   S. aureus 
                 
                 SdrC4 
                 MAEHTNGELNQSKNETTAPSENKTTKKVDS 
               
               
                   
                   
                   
                   
                 RQLKDNTQTATADQPKVTMSDSATVKETSS 
               
               
                   
                   
                   
                   
                 NMQSPQNATANQSTTKTSNVTTNDKSSTTYS 
               
               
                   
                   
                   
                   
                 NETDKSNLTQAKDVSTTPKTTTIKPRTLNRM 
               
               
                   
                   
                   
                   
                 AVNTVAAPQQGTNVNDKVHFSNIDIAIDKGH 
               
               
                   
                   
                   
                   
                 VNQTTGKTEFWATSSDVLKLKANYTIDDSVK 
               
               
                   
                   
                   
                   
                 EGDTFTFKYGQYFRPGSVRLPSQTQNLYNAQ 
               
               
                   
                   
                   
                   
                 GNIIAKGIYDSTTNTTTYTFTNYVDQYTNVRG 
               
               
                   
                   
                   
                   
                 SFEQVAFAKRKNATTDKTAYKMEVTLGNDT 
               
               
                   
                   
                   
                   
                 YSEEIIVDYGNKKAQPLISSTNYINNEDLSRN 
               
               
                   
                   
                   
                   
                 MTAYVNQPKNTYTKQTFVTNLTGYKFNPNA 
               
               
                   
                   
                   
                   
                 KNFKIYEVTDQNQFVDSFTPDTSKLKDVTDQ 
               
               
                   
                   
                   
                   
                 FDVIYSNDNKTATVDLMKGQTSSNKQYIIQQ 
               
               
                   
                   
                   
                   
                 VAYPDNSSTDNGKIDYTLDTDKTKYSWSNSY 
               
               
                   
                   
                   
                   
                 SNVNGSSTANGDQKKYNLGDYVWEDTNKD 
               
               
                   
                   
                   
                   
                 GKQDANEKGIKGVYVILKDSNGKELDRTTTD 
               
               
                   
                   
                   
                   
                 ENGKYQFTGLSNGTYSVEFSTPAGYTPTTAN 
               
               
                   
                   
                   
                   
                 VGTDDAVDSDGLTTTGVIKDADNMTLDSGF 
               
               
                   
                   
                   
                   
                 YKTPKYSLGDYVWYDSNKDGKQDSTEKGIK 
               
               
                   
                   
                   
                   
                 GVKVTLQNEKGEVIGTTETDENGKYRFDNLD 
               
               
                   
                   
                   
                   
                 SGKYKVIFEKPAGLTQTGTNTTEDDKDADGG 
               
               
                   
                   
                   
                   
                 EVDVTITDHDDFTLDNGYYEEETSDSDSDSD 
               
               
                   
                   
                   
                   
                 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 
               
               
                   
                   
                   
                   
                 SDSDSDSDSNSDSDSDSDSDSDSDSDSDSDSD 
               
               
                   
                   
                   
                   
                 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 
               
               
                   
                   
                   
                   
                 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 
               
               
                   
                   
                   
                   
                 SDSDSDSDSDSDSDSDSDSDSDNDSDSDSDSD 
               
               
                   
                   
                   
                   
                 SDAGKHTPAKPMSTVKDQHKTAKALEHHHH 
               
               
                   
                   
                   
                   
                 HH 
               
               
                   
               
               
                 101 
                 PRT 
                 
                   S. aureus 
                 
                 SdrC5 
                 MTPKYSLGDYVWYDSNKDGKQDSTEKGIKG 
               
               
                   
                   
                   
                   
                 VKVTLQNEKGEVIGTTETDENGKYRFDNLDS 
               
               
                   
                   
                   
                   
                 GKYKVIFEKPAGLTQTGTNTTEDDKDADGGE 
               
               
                   
                   
                   
                   
                 VDVTITDHDDFTLDNGYYEEETSDSDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSDSNSDSDSDSDSDSDSDSDSDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSDSDSDSDSDSDSDSDNDSDSDSDSDS 
               
               
                   
                   
                   
                   
                 DAGKHTPAKPMSTVKDQHKTAKALPETGLE 
               
               
                   
                   
                   
                   
                 HHHHHH 
               
               
                   
               
               
                 102 
                 PRT 
                 Human 
                 Pagibaximab 
                 EVMLVESGGGLVQPKGSLKLSCAASGFTFNN 
               
               
                   
                   
                   
                 Heavy Chain 
                 YAMNWVRQAPGKGLEWVARIRSKSNNYAT 
               
               
                   
                   
                   
                   
                 FYADSVKDRFTISRDDSQSMLYLQMNNLKTE 
               
               
                   
                   
                   
                   
                 DTAMYYCVRRGASGIDYAMDYWGQGTSLT 
               
               
                   
                   
                   
                   
                 VSSASTKGPSVFPLAPSSKSTSGGTAALGCLV 
               
               
                   
                   
                   
                   
                 KDYFPEPVTVSWNSGALTSGVHTFPAVLQSS 
               
               
                   
                   
                   
                   
                 GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT 
               
               
                   
                   
                   
                   
                 KVDKKVEPKSCDKTHTCPPCPAPELLGGPSV 
               
               
                   
                   
                   
                   
                 FLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE 
               
               
                   
                   
                   
                   
                 VKFNWYVDGVEVHNAKTKPREEQYNSTYR 
               
               
                   
                   
                   
                   
                 VVSVLTVLHQDWLNGKEYKCKVSNKALPAP 
               
               
                   
                   
                   
                   
                 IEKTISKAKGQPREPQVYTLPPSRDELTKNQV 
               
               
                   
                   
                   
                   
                 SLTCLVKGFYPSDIAVEWESNGQPENNYKTT 
               
               
                   
                   
                   
                   
                 PPVLDSDGSFFLYSKLTVDKSRWQQGNVFSC 
               
               
                   
                   
                   
                   
                 SVMHEALHNHYTQKSLSLSPGK 
               
               
                   
               
               
                 103 
                 PRT 
                 Human 
                 Pagibaximab 
                 DIVLSQSPAILSASPGEKVTMTCRASSSVNYM 
               
               
                   
                   
                   
                 Light Chain 
                 HWYQQKPGSSPKPWISATSNLASGVPARFSG 
               
               
                   
                   
                   
                   
                 SGSGTSYSLTISRVEAEDAATYYCQQWSSNPP 
               
               
                   
                   
                   
                   
                 TFGGGTMLEIKRTVAAPSVFIFPPSDEQLKSG 
               
               
                   
                   
                   
                   
                 TASVVCLLNNFYPREAKVQWKVDNALQSGN 
               
               
                   
                   
                   
                   
                 SQESVTEQDSKDSTYSLSSTLTLSKADYEKHK 
               
               
                   
                   
                   
                   
                 VYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 104 
                 PRT 
                 Human 
                 CNTO3930 
                 QITLKESGPTLVKPTQTLTLTCTFSGFSLSTSG 
               
               
                   
                   
                   
                 Heavy Chain 
                 MGVSWIRQPPGKALEWLAHIYWDDDKRYNP 
               
               
                   
                   
                   
                   
                 SLKSRLTITKDTSKNQVVLTMTNMDPVDTAT 
               
               
                   
                   
                   
                   
                 YYCARLYGFTYGFAYWGQGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSS 
               
               
                   
                   
                   
                   
                 VVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 
               
               
                   
                   
                   
                   
                 EPKSCDKTHTCPPCPAPELLGGPSVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNKALPAPIEKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNHYTQKSLSLSPGK 
               
               
                   
               
               
                 105 
                 PRT 
                 Human 
                 CNTO3930 
                 DIVMTQSPDSLAVSLGERATINCRASQSVDY 
               
               
                   
                   
                   
                 Light Chain 
                 NGISYMHWYQQKPGQPPKLLIYAASNPESGV 
               
               
                   
                   
                   
                   
                 PDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQ 
               
               
                   
                   
                   
                   
                 IIEDPWTFGQGTKVEIKRTVAAPSVFIFPPSDE 
               
               
                   
                   
                   
                   
                 QLKSGTASVVCLLNNFYPREAKVQWKVDNA 
               
               
                   
                   
                   
                   
                 LQSGNSQESVTEQDSKDSTYSLSSTLTLSKAD 
               
               
                   
                   
                   
                   
                 YEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 106 
                 PRT 
                 Human 
                 CNTO3929 
                 QITLKESGPTLVKPTQTLTLTCTFSGFSLSTSG 
               
               
                   
                   
                   
                 Heavy Chain 
                 MGVSWIRQPPGKALEWLAHIYWDDDKRYNP 
               
               
                   
                   
                   
                   
                 SLKSRLTITKDTSKNQVVLTMTNMDPVDTAT 
               
               
                   
                   
                   
                   
                 YYCARLYGFTYGFAYWGQGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSS 
               
               
                   
                   
                   
                   
                 VVTVPSSSLGTQTYICNVNHKPSNTKVDKKA 
               
               
                   
                   
                   
                   
                 EPKSCDKTHTCPPCPAPELLGGPSVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNKALPAPIEKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNHYTQKSLSLSPGK 
               
               
                   
               
               
                 107 
                 PRT 
                 Human 
                 CNTO3929 
                 DIVMTQSPDSLAVSLGERATINCRASQSVDY 
               
               
                   
                   
                   
                 Light Chain 
                 NGISYMHWYQQKPGQPPKLLIYAASNPESGV 
               
               
                   
                   
                   
                   
                 PDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQ 
               
               
                   
                   
                   
                   
                 IIEDPWTFGQGTKVEIKRTVAAPSVFIFPPSDE 
               
               
                   
                   
                   
                   
                 QLKSGTASVVCLLNNFYPREAKVQWKVDNA 
               
               
                   
                   
                   
                   
                 LQSGNSQESVTEQDSKDSTYSLSSTLTLSKAD 
               
               
                   
                   
                   
                   
                 YEKHKVYACEVTHQGLSLPVTKSFNRGEC 
               
               
                   
               
               
                 108 
                 PRT 
                 
                   S. aureus 
                 
                 HlgA 
                 NSAHHHHHHGSENKIEDIGQGAEIIKRTQDIT 
               
               
                   
                   
                   
                   
                 SKRLAITQNIQFDFVKDKKYNKDALVVKMQ 
               
               
                   
                   
                   
                   
                 GFISSRTTYSDLKKYPYIKRMIWPFQYNISLKT 
               
               
                   
                   
                   
                   
                 KDSNVDLINYLPKNKIDSADVSQKLGYNIGG 
               
               
                   
                   
                   
                   
                 NFQSAPSIGGSGSFNYSKTISYNQKNYVTEVE 
               
               
                   
                   
                   
                   
                 SQNSKGVKWGVKANSFVTPNGQVSAYDQYL 
               
               
                   
                   
                   
                   
                 FAQDPTGPAARDYFVPDNQLPPLIQSGFNPSFI 
               
               
                   
                   
                   
                   
                 TTLSHERGKGDKSEFEITYGRNMDATYAYVT 
               
               
                   
                   
                   
                   
                 RHRLAVDRKHDAFKNRNVTVKYEVNWKTH 
               
               
                   
                   
                   
                   
                 EVKIKSITPK 
               
               
                   
               
               
                 109 
                 PRT 
                 
                   S. aureus 
                 
                 HlgB 
                 NSAHHHHHHGSEGKITPVSVKKVDDKVTLY 
               
               
                   
                   
                   
                   
                 KTTATADSDKFKISQILTFNFIKDKSYDKDTL 
               
               
                   
                   
                   
                   
                 VLKATGNINSGFVKPNPNDYDFSKLYWGAK 
               
               
                   
                   
                   
                   
                 YNVSISSQSNDSVNVVDYAPKNQNEEFQVQN 
               
               
                   
                   
                   
                   
                 TLGYTFGGDISISNGLSGGLNGNTAFSETINY 
               
               
                   
                   
                   
                   
                 KQESYRTTLSRNTNYKNVGWGVEAHKIMNN 
               
               
                   
                   
                   
                   
                 GWGPYGRDSFHPTYGNELFLAGRQSSAYAG 
               
               
                   
                   
                   
                   
                 QNFIAQHQMPLLSRSNFNPEFLSVLSHRQDG 
               
               
                   
                   
                   
                   
                 AKKSKITVTYQREMDLYQIRWNGFYWAGAN 
               
               
                   
                   
                   
                   
                 YKNFKTRTFKSTYEIDWENHKVKLLDTKETE 
               
               
                   
                   
                   
                   
                 NNK 
               
               
                   
               
               
                 110 
                 PRT 
                 
                   S. aureus 
                 
                 HlgC 
                 NSAHHHHHHGSANDTEDIGKGSDIEIIKRTED 
               
               
                   
                   
                   
                   
                 KTSNKWGVTQNIQFDFVKDKKYNKDALILK 
               
               
                   
                   
                   
                   
                 MQGFISSRTTYYNYKKTNHVKAMRWPFQYN 
               
               
                   
                   
                   
                   
                 IGLKTNDKYVSLINYLPKNKIESTNVSQTLGY 
               
               
                   
                   
                   
                   
                 NIGGNFQSAPSLGGNGSFNYSKSISYTQQNYV 
               
               
                   
                   
                   
                   
                 SEVEQQNSKSVLWGVKANSFATESGQKSAF 
               
               
                   
                   
                   
                   
                 DSDLFVGYKPHSKDPRDYFVPDSELPPLVQS 
               
               
                   
                   
                   
                   
                 GFNPSFIATVSHEKGSSDTSEFEITYGRNMDV 
               
               
                   
                   
                   
                   
                 THAIKRSTHYGNSYLDGHRVHNAFVNRNYT 
               
               
                   
                   
                   
                   
                 VKYEVNWKTHEIKVKGQN 
               
               
                   
               
               
                 111 
                 PRT 
                 
                   S. aureus 
                 
                 LukF-PV 
                 NSAHHHHHHGSAQHITPVSEKKVDDKITLYK 
               
               
                   
                   
                   
                   
                 TTATSDSDKLKISQILTFNFIKDKSYDKDTLIL 
               
               
                   
                   
                   
                   
                 KAAGNIYSGYTKPNPKDTISSQFYWGSKYNIS 
               
               
                   
                   
                   
                   
                 INSDSNDSVNVVDYAPKNQNEEFQVQQTVG 
               
               
                   
                   
                   
                   
                 YSYGGDINISNGLSGGGNGSKSFSETINYKQE 
               
               
                   
                   
                   
                   
                 SYRTSLDKRTNFKKIGWDVEAHKIMNNGWG 
               
               
                   
                   
                   
                   
                 PYGRDSYHSTYGNEMFLGSRQSNLNAGQNF 
               
               
                   
                   
                   
                   
                 LEYHKMPVLSRGNFNPEFIGVLSRKQNAAKK 
               
               
                   
                   
                   
                   
                 SKITVTYQREMDRYTNFWNQLHWIGNNYKD 
               
               
                   
                   
                   
                   
                 ENRATHTSIYEVDWENHTVKLIDTQSKEKNP 
               
               
                   
                   
                   
                   
                 MS 
               
               
                   
               
               
                 112 
                 PRT 
                 
                   S. aureus 
                 
                 LukS-PV 
                 NSAHHHHHHGSDNNIENIGDGAEVVKRTEDT 
               
               
                   
                   
                   
                   
                 SSDKWGVTQNIQFDFVKDKKYNKDALILKM 
               
               
                   
                   
                   
                   
                 QGFINSKTTYYNYKNTDHIKAMRWPFQYNIG 
               
               
                   
                   
                   
                   
                 LKTNDPNVDLINYLPKNKIDSVNVSQTLGYNI 
               
               
                   
                   
                   
                   
                 GGNFNSGPSTGGNGSFNYSKTISYNQQNYISE 
               
               
                   
                   
                   
                   
                 VERQNSKSVQWGIKANSFITSLGKMSGHDPN 
               
               
                   
                   
                   
                   
                 LFVGYKPYSQNPRDYFVPDNELPPLVHSGFN 
               
               
                   
                   
                   
                   
                 PSFIATVSHEKGSGDTSEFEITYGRNMDVTHA 
               
               
                   
                   
                   
                   
                 TRRTTHYGNSYLEGSRIHNAFVNRNYTVKYE 
               
               
                   
                   
                   
                   
                 VNWKTHEIKVKGHN 
               
               
                   
               
               
                 113 
                 PRT 
                 Artificial 
                 Luk82 LukE, 
                 LPAPKNLVVSRVTEDSARLSWSNRAITTFDSF 
               
               
                   
                   
                   
                 LukF binding 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYTVSIYGVEYRFRPKYTGSNPLSAIFTT 
               
               
                   
               
               
                 114 
                 PRT 
                 Artificial 
                 Luk83 LukF 
                 LPAPKNLVVSRVTEDSARLSWFRPSEDISSFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVAFPTDAKSNPLSAIFTT 
               
               
                   
               
               
                 115 
                 PRT 
                 Artificial 
                 Luk85 LukF 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 HINYNEEALVGEAIVLTVPGSERSCDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYGVEIEGVKGGPWSWPLSAIFTT 
               
               
                   
               
               
                 116 
                 PRT 
                 Artificial 
                 Luk86 LukE, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukF binding 
                 YIRYNEIDLHGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYQVPIAGVKVCIISKPLSAIFTT 
               
               
                   
               
               
                 117 
                 PRT 
                 Artificial 
                 Luk87 LukE 
                 LPAPKNLVVSRVTEDSARLSWANTEPSYFAF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVVWVTWGKSNPLSAIFTT 
               
               
                   
               
               
                 118 
                 PRT 
                 Artificial 
                 Luk88 LukE 
                 LPAPKNLVVSRVTEDSARLSWTLEWSLIFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVQRSVAWYFLLLASNPLSAIFTT 
               
               
                   
               
               
                 119 
                 PRT 
                 Artificial 
                 Luk90 LukE 
                 LPAPKNLVVSRVTEDSARLSWRTYPTLFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVWPRNIQPWSNPLSAIFTT 
               
               
                   
               
               
                 120 
                 PRT 
                 Artificial 
                 Luk92 LukE 
                 LPAPKNLVVSRVTEDSARLSWKRVKWVSYQ 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                 domain 
                 GLKPGTEYTVSIYGVASIDETVGVSNPLSAIFTT 
               
               
                   
               
               
                 121 
                 PRT 
                 Artificial 
                 Luk93 LukE, 
                 LPAPKNLVVSRVTEDSARLSWWRRISRFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYTVSIYGVDREVYDEWSSNPLSAIFTT 
               
               
                   
               
               
                 122 
                 PRT 
                 Artificial 
                 Luk94 LukE 
                 LPAPKNLVVSRVTEDSARLSWYRRFLLFIFFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVGEQWGEASDLSNPLSAIFTT 
               
               
                   
               
               
                 123 
                 PRT 
                 Artificial 
                 Luk95 LukE 
                 LPAPKNLVVSRVTEDSARLSWQHSQYFVLFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVLYRQWRDSNPLSAIFTT 
               
               
                   
               
               
                 124 
                 PRT 
                 Artificial 
                 Luk96 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVEHWPSWWHLNFSNPLSAIFTT 
               
               
                   
               
               
                 125 
                 PRT 
                 Artificial 
                 Luk97 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVIDIIHINSWNDHSNPLSAIFTT 
               
               
                   
               
               
                 126 
                 PRT 
                 Artificial 
                 Luk98 LukE 
                 LPAPKNLVVSRVTEDSARLSWNRHSHEFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVRIWVLKLNESNPLSAIFTT 
               
               
                   
               
               
                 127 
                 PRT 
                 Artificial 
                 Luk99 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 EIIYYERHDNGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYLVWIPGVKGGLTSWPLSAIFTT 
               
               
                   
               
               
                 128 
                 PRT 
                 Artificial 
                 Luk100 LukE, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 PITYGEYRSVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYIVDIYGVKGGLFSYPLSAIFTT 
               
               
                   
               
               
                 129 
                 PRT 
                 Artificial 
                 Luk101 LukE 
                 LPAPKNLVVSRVTEDSARLSWDTEPEWFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVQRVEIRALYRSYSNPLSAIFTT 
               
               
                   
               
               
                 130 
                 PRT 
                 Artificial 
                 Luk102 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVSHRFWKHVYFYSNPLSAIFTT 
               
               
                   
               
               
                 131 
                 PRT 
                 Artificial 
                 Luk103 LukE 
                 LPAPKNLVVSRVTEDSARLSWIIGLSRFDSFLI 
               
               
                   
                   
                   
                 binding FN3 
                 QYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVDFAHQDFFRGYASNPLSAIFTT 
               
               
                   
               
               
                 132 
                 PRT 
                 Artificial 
                 Luk104 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVQWWVVAFHHAPSNPLSAIFTT 
               
               
                   
               
               
                 133 
                 PRT 
                 Artificial 
                 Luk106 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVVAWIFTKVLNASNPLSAIFTT 
               
               
                   
               
               
                 134 
                 PRT 
                 Artificial 
                 Luk107 LukE 
                 LPAPKNLVVSRVTEDSARLSWKGPNSPPSQF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVWKWRTRAHSNPLSAIFTT 
               
               
                   
               
               
                 135 
                 PRT 
                 Artificial 
                 Luk108 LukE 
                 LPAPKNLVVSRVTEDSARLSWFYYYLGKFGF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVVNWRWWPDDSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 136 
                 PRT 
                 Artificial 
                 Luk109 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVIINRFWAWYLASSNPLSAIFTT 
               
               
                   
               
               
                 137 
                 PRT 
                 Artificial 
                 Luk110 LukS, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukF binding 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYTVSIYGVGFPTFLNYWQFGSNPLSAIFTT 
               
               
                   
               
               
                 138 
                 PRT 
                 Artificial 
                 Luk112 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 EIHYYEFRHHGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYAFWIYGVKGGGSSWPLSAIFTT 
               
               
                   
               
               
                 139 
                 PRT 
                 Artificial 
                 Luk113 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WIEYHEEYETGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVWIAGVKGGKWSWPLSAIFTT 
               
               
                   
               
               
                 140 
                 PRT 
                 Artificial 
                 Luk114 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 EIHYQELPQKGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYVVWIWGVKGGLTSDPLSAIFTT 
               
               
                   
               
               
                 141 
                 PRT 
                 Artificial 
                 Luk116 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 EIHYQEYPAFGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYIVWIWGVKGGWTSWPLSAIFTT 
               
               
                   
               
               
                 142 
                 PRT 
                 Artificial 
                 Luk117 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 EIHYQETISVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYWVLIWGVKGGAASDPLSAIFTT 
               
               
                   
               
               
                 143 
                 PRT 
                 Artificial 
                 Luk119 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 SIDYFEEYQKGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVWIFGVKGGIRSWPLSAIFTT 
               
               
                   
               
               
                 144 
                 PRT 
                 Artificial 
                 Luk120 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 EINYWEAYIHGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVWIHGVKGGGNSYPLSAIFTT 
               
               
                   
               
               
                 145 
                 PRT 
                 Artificial 
                 Luk122 HlgA, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukAB binding 
                 EIHYYEFAIKGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYAVWIYGVKGGNSSWPLSAIFTT 
               
               
                   
               
               
                 146 
                 PRT 
                 Artificial 
                 Luk123 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 EIDYFEEYSHGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVWINGVKGGIYSYPLSAIFTT 
               
               
                   
               
               
                 147 
                 PRT 
                 Artificial 
                 Luk124 HlgA, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukD binding 
                 TIDYVESYALGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYWVWIWGVKGGSLSYPMSAIFTT 
               
               
                   
               
               
                 148 
                 PRT 
                 Artificial 
                 Luk125 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 PIIYYEHHNFGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYAVPIPGVKGGWQSLPLSAIFTT 
               
               
                   
               
               
                 149 
                 PRT 
                 Artificial 
                 Luk126 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 YIDYQEWPSVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYSVFIHGVKGGWLSKPLSAIFTT 
               
               
                   
               
               
                 150 
                 PRT 
                 Artificial 
                 Luk128 HlgA, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukD binding 
                 DIQYFEEYAIGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYWVWISGVKGGNFSKPLSAIFTT 
               
               
                   
               
               
                 151 
                 PRT 
                 Artificial 
                 Luk129 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 NINYPEEFHGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYEVWIWGVKGGSSSNPLSAIFTT 
               
               
                   
               
               
                 152 
                 PRT 
                 Artificial 
                 Luk130 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 NIHYLEWEVNGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYIVEIWGVKGGYSSWPLSAIFTT 
               
               
                   
               
               
                 153 
                 PRT 
                 Artificial 
                 Luk132 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 YIEYWEWDPVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYPVFISGVKGGYPSVPLSAIFTT 
               
               
                   
               
               
                 154 
                 PRT 
                 Artificial 
                 Luk133 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFI 
               
               
                   
                   
                   
                 binding FN3 
                 IHYGEGPEFGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYSVHIPGVKGGWLSWPLSAIFTT 
               
               
                   
               
               
                 155 
                 PRT 
                 Artificial 
                 Luk134 HlgA, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukE binding 
                 TIVYLEWVVLGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYIVDIYGVKGGWTSRPLSAIFTT 
               
               
                   
               
               
                 156 
                 PRT 
                 Artificial 
                 Luk136 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukAB, LukD 
                 TIDYFEEYVVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 binding FN3 
                 GTEYWVCIVGVKGGTPSPPLSAIFTT 
               
               
                   
                   
                   
                 domain 
                   
               
               
                   
               
               
                 157 
                 PRT 
                 Artificial 
                 Luk138 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 HIWYQEFEVRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYDVEIWGVKGGSHSWTLSAIFTT 
               
               
                   
               
               
                 158 
                 PRT 
                 Artificial 
                 Luk139 HlgA, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFNSF 
               
               
                   
                   
                   
                 LukAB 
                 EIHYGEWEYGGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 binding FN3 
                 PGTEYTVWIYGVKGGDSSWPLSAIFTT 
               
               
                   
                   
                   
                 domain 
                   
               
               
                   
               
               
                 159 
                 PRT 
                 Artificial 
                 Luk140 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 EIHYQETKKSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVLIWGVKGGTASNPLSAIFTT 
               
               
                   
               
               
                 160 
                 PRT 
                 Artificial 
                 Luk143 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 DIQYDERTEEGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVTIPGVKGGWYSWPLSAIFTT 
               
               
                   
               
               
                 161 
                 PRT 
                 Artificial 
                 Luk144 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WIDYFEEWVNGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYWVWIQGVKGGVHSPPLSAIFTT 
               
               
                   
               
               
                 162 
                 PRT 
                 Artificial 
                 Luk148 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 EIHYQELNRVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVLIWGVKGGDSSEPLSAIFTT 
               
               
                   
               
               
                 163 
                 PRT 
                 Artificial 
                 Luk151 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GITYTEVYWWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVTIPGVKGGWISAPLSAIFTT 
               
               
                   
               
               
                 164 
                 PRT 
                 Artificial 
                 Luk155 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 SIRYFEFIKPGEAIWLGVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYHVQIRGVKGGRESYPLWADFTT 
               
               
                   
               
               
                 165 
                 PRT 
                 Artificial 
                 Luk156 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 EIQYHETRYSGEAIWLWVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYSVYIPGVKGGNVSFPLKAHFTT 
               
               
                   
               
               
                 166 
                 PRT 
                 Artificial 
                 Luk158 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AISYKESGRIGEAISLIVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYWVYINGVKGGITSFPLNAWFTT 
               
               
                   
               
               
                 167 
                 PRT 
                 Artificial 
                 Luk159 HlgA, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukAB binding 
                 GIDYKETGYTGEAIELEVPGSEHSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVTIGGVKGGYSSWPLVALFTT 
               
               
                   
               
               
                 168 
                 PRT 
                 Artificial 
                 Luk160 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 VIWYTENPSLGEAIKLSVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYVVEIWGVKGGRGSVPLFAIFTT 
               
               
                   
               
               
                 169 
                 PRT 
                 Artificial 
                 Luk163 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 YIEYWEPTSDGEAIALNVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVEIWGVKGGPRSPPLSAWFTT 
               
               
                   
               
               
                 170 
                 PRT 
                 Artificial 
                 Luk164 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 DIEYGEPEKIGEAIWLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVFIYGVKGGALSRPLTATSTT 
               
               
                   
               
               
                 171 
                 PRT 
                 Artificial 
                 Luk166 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WIQYFEIQPWGEAILLDVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYSVIIWGVKGGPKSQPLYAWFTT 
               
               
                   
               
               
                 172 
                 PRT 
                 Artificial 
                 Luk167 LukD 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 VIIYSEDTIPGEAIVLWVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYYVQIEGVKGGHESFPLVANFTT 
               
               
                   
               
               
                 173 
                 PRT 
                 Artificial 
                 Luk174 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 DIEYGEPEKIGEAIWLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVFIYGVKGGALSRPLTATFTT 
               
               
                   
               
               
                 174 
                 PRT 
                 Artificial 
                 Luk176 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 VIYYHEFPYGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYYVRILGVKGGGLSYPLSAIFTT 
               
               
                   
               
               
                 175 
                 PRT 
                 Artificial 
                 Luk177 LukD 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIYYREWGSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYLVITGVKGGNPSYPLSAIFTT 
               
               
                   
               
               
                 176 
                 PRT 
                 Artificial 
                 Luk178 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIHYFEAYAGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVWIFGVKGGLYSYPLSAIFTT 
               
               
                   
               
               
                 177 
                 PRT 
                 Artificial 
                 Luk179 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 EINYFEAWDGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVWISGVKGGRYSYPLSAIFTT 
               
               
                   
               
               
                 178 
                 PRT 
                 Artificial 
                 Luk180 HlgA 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 EIHYYEPIYVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYIVWIYGVKGGYSSWPLSAIFTT 
               
               
                   
               
               
                 179 
                 PRT 
                 Artificial 
                 Luk182 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 YILYIENDWQGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVVIHGVKGGWISPPLSAIFTT 
               
               
                   
               
               
                 180 
                 PRT 
                 Artificial 
                 Luk183 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 TIWYWEFLHNGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYFVEIYGVKGGSVSVPLSAIFTT 
               
               
                   
               
               
                 181 
                 PRT 
                 Artificial 
                 Luk184 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 TIIYHELNTAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYLVIIHGVKGGPISSPLSAIFTT 
               
               
                   
               
               
                 182 
                 PRT 
                 Artificial 
                 Luk185 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 RIVYREWFHYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYYVVIHGVKGGYISKPLSAIFTT 
               
               
                   
               
               
                 183 
                 PRT 
                 Artificial 
                 Luk186 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 HITYTEYSFVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVEIYGVKGGFISSPLSAIFTT 
               
               
                   
               
               
                 184 
                 PRT 
                 Artificial 
                 Luk187 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 RILYFEYKRLGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVGIHGVKGGYISRPLSAIFTT 
               
               
                   
               
               
                 185 
                 PRT 
                 Artificial 
                 Luk188 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 HIHYWEFNPAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVGIHGVKGGGISWPLSAIFTT 
               
               
                   
               
               
                 186 
                 PRT 
                 Artificial 
                 Luk189 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSL 
               
               
                   
                   
                   
                 binding FN3 
                 KIFYFEFIYLGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYHVTIHGVKGGTISLPLSAIFTT 
               
               
                   
               
               
                 187 
                 PRT 
                 Artificial 
                 Luk190 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 HIFYYEFSNYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVIIHGVKGGQISVPLSAIFTT 
               
               
                   
               
               
                 188 
                 PRT 
                 Artificial 
                 Luk191 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYWEWYHGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYNVVIHGVKGGYISLPLSAIFTT 
               
               
                   
               
               
                 189 
                 PRT 
                 Artificial 
                 Luk192 HlgC 
                 LPAPKNLDVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 VIFYYEEKPIGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYFVEIYGVKGGYISNPLSAIFTT 
               
               
                   
               
               
                 190 
                 PRT 
                 Artificial 
                 Luk193 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 NIFYHETRPLGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVAIYGVKGGYISLPLSAIFTT 
               
               
                   
               
               
                 191 
                 PRT 
                 Artificial 
                 Luk194 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 TIHYWEFSDNGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYLVGIYGVKGGQISQPLSAIFTT 
               
               
                   
               
               
                 192 
                 PRT 
                 Artificial 
                 Luk195 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukD binding 
                 HIIYYEYPAGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYHVIIHGVKGGFVSVPLSAIFTT 
               
               
                   
               
               
                 193 
                 PRT 
                 Artificial 
                 Luk196 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 NIIYIENPYWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVIIHGVKGGYISEPLSAIFTT 
               
               
                   
               
               
                 194 
                 PRT 
                 Artificial 
                 Luk197 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TILYWEVQANGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYVVGIYGVKGGYISLPLSAIFTT 
               
               
                   
               
               
                 195 
                 PRT 
                 Artificial 
                 Luk198 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 QIFYTEEKTWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVWIHGVKGGWISAPLSAIFTT 
               
               
                   
               
               
                 196 
                 PRT 
                 Artificial 
                 Luk199 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TILYAEHSNKGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVGIYGVKGGFISWPLSAIFTT 
               
               
                   
               
               
                 197 
                 PRT 
                 Artificial 
                 Luk201 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYLEHNDEGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYWVAIHGVKGGYISQPLSAIFTT 
               
               
                   
               
               
                 198 
                 PRT 
                 Artificial 
                 Luk202 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 RIWYHETWRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYPVVIHGVKGGFISTPLSAIFTT 
               
               
                   
               
               
                 199 
                 PRT 
                 Artificial 
                 Luk203 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 TIIYVEYETWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYIVAIHGVKGGYISIPLSAIFTT 
               
               
                   
               
               
                 200 
                 PRT 
                 Artificial 
                 Luk204 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 PIIYWELWSIGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYFVEIYGVKGGTISTPLSAIFTT 
               
               
                   
               
               
                 201 
                 PRT 
                 Artificial 
                 Luk205 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 SILYWEWVANGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYFVEIYGVKGGWLSLPLSAIFTT 
               
               
                   
               
               
                 202 
                 PRT 
                 Artificial 
                 Luk206 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIFYFEQFSRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVAIHGVKGGFVSRPLSAIFTT 
               
               
                   
               
               
                 203 
                 PRT 
                 Artificial 
                 Luk208 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 TIWYWEWYHLGEAIVLTVPGSELSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYWVEIYGVKGGFISQPLSAIFTT 
               
               
                   
               
               
                 204 
                 PRT 
                 Artificial 
                 Luk210 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 PIFYFEYLGNGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVGIHGVKGGVISTPLSAIFTT 
               
               
                   
               
               
                 205 
                 PRT 
                 Artificial 
                 Luk211 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 TIIYFEWKRLGEAIVPTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVGIYGVKGGPISVPLSAIFTT 
               
               
                   
               
               
                 206 
                 PRT 
                 Artificial 
                 Luk212 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 TILYTEREFYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVGIYGVKGGNISEPLSAIFTT 
               
               
                   
               
               
                 207 
                 PRT 
                 Artificial 
                 Luk213 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 HIFYHETDAYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKGGFISSPLSAIFTT 
               
               
                   
               
               
                 208 
                 PRT 
                 Artificial 
                 Luk214 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIHYWEYDANGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYLVAIYGVKGGLISVPLSAIFTT 
               
               
                   
               
               
                 209 
                 PRT 
                 Artificial 
                 Luk215 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TILYHESVTNGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVGIYGVKGGYISDPLSAIFTT 
               
               
                   
               
               
                 210 
                 PRT 
                 Artificial 
                 Luk216 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 RIHYFEESITGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 FN3 domain 
                 TEYFVAIYGVKGGSISDPLSAIFTT 
               
               
                   
               
               
                 211 
                 PRT 
                 Artificial 
                 Luk218 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 SIIYWEYRWQGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYIVPIHGVKGGEISPPLSAIFTT 
               
               
                   
               
               
                 212 
                 PRT 
                 Artificial 
                 Luk219 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 TIWYWVYRTSGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYFVAIHGVKGGEISVPLSAIFTT 
               
               
                   
               
               
                 213 
                 PRT 
                 Artificial 
                 Luk220 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIFYWEESPPGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVAIYGVKGGYISLPLSAIFTT 
               
               
                   
               
               
                 214 
                 PRT 
                 Artificial 
                 Luk221 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS, LukD, 
                 AIFYHELEHHGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 LukAB binding 
                 GTEYFVAIHGVKGGQISWPLSAIFTT 
               
               
                   
                   
                   
                 FN3 domain 
                   
               
               
                   
               
               
                 215 
                 PRT 
                 Artificial 
                 Luk222 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 SILYWEEEFGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 FN3 domain 
                 TEYFVAIHGVKGGYISRPLSAIFTT 
               
               
                   
               
               
                 216 
                 PRT 
                 Artificial 
                 Luk223 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VILYWEEENQGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIHGVKGGHISEPLSAIFTT 
               
               
                   
               
               
                 217 
                 PRT 
                 Artificial 
                 Luk224 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYTEHGVSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYWVPIHGVKGGTISQPLSAIFTT 
               
               
                   
               
               
                 218 
                 PRT 
                 Artificial 
                 Luk225 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 QIFYHEFLTIGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYIVAIYGVKGGQISDPLSAIFTT 
               
               
                   
               
               
                 219 
                 PRT 
                 Artificial 
                 Luk226 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 TIHYAEWHLDGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYFVAIHGVKGGYISEPLSAIFTT 
               
               
                   
               
               
                 220 
                 PRT 
                 Artificial 
                 Luk227 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 RIYYHEWQATGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYLVVIHGVKGGWISSPLSAIFTT 
               
               
                   
               
               
                 221 
                 PRT 
                 Artificial 
                 Luk228 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIPYYEYAVFGEATVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYHVIIHGVKGGYISLPLSAIFTT 
               
               
                   
               
               
                 222 
                 PRT 
                 Artificial 
                 Luk229 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 YIFYLEWNQIGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIYGVKGGFISDPLSAIFTT 
               
               
                   
               
               
                 223 
                 PRT 
                 Artificial 
                 Luk230 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFI 
               
               
                   
                   
                   
                 binding FN3 
                 IFYTESHFYGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYWVAIYGVKGGEFSFPLSAIFTT 
               
               
                   
               
               
                 224 
                 PRT 
                 Artificial 
                 Luk231 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 RILYWEYVTAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKGGYISIPLSAIFTT 
               
               
                   
               
               
                 225 
                 PRT 
                 Artificial 
                 Luk233 HlgC 
                 LPAPKNLVVSRVTEDSACLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIQYWEYSGIGEAIVLTVPGSERSYGLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVGIAGVKGGWISLPLSAIFTT 
               
               
                   
               
               
                 226 
                 PRT 
                 Artificial 
                 Luk235 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukAB binding 
                 SIIYHEWDKNGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIYGVKGGYISRPLSAIFTT 
               
               
                   
               
               
                 227 
                 PRT 
                 Artificial 
                 Luk236 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 NIFYWEYILPGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYWVIIHGVKGGHISDPLSAIFTT 
               
               
                   
               
               
                 228 
                 PRT 
                 Artificial 
                 Luk237 HlgC 
                 MLPPPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FQIIYWEYAETGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYIVIIHGVKGGEISRPLSAIFTT 
               
               
                   
               
               
                 229 
                 PRT 
                 Artificial 
                 Luk238 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIFYHETVKSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKRGQISEPLSAIFTT 
               
               
                   
               
               
                 230 
                 PRT 
                 Artificial 
                 Luk239 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 HISYWEYAVYGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYFVGIYGVKGGWISSPLSAIFTT 
               
               
                   
               
               
                 231 
                 PRT 
                 Artificial 
                 Luk240 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 PIFYDEEAHNGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKGGTISIPLSAIFTT 
               
               
                   
               
               
                 232 
                 PRT 
                 Artificial 
                 Luk241 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIYYFESYAVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIYGVKGGWISWPLSAIFTT 
               
               
                   
               
               
                 233 
                 PRT 
                 Artificial 
                 Luk242 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VIFYHETEVDGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYVVIIHGVKGGFISYPLSAIFTT 
               
               
                   
               
               
                 234 
                 PRT 
                 Artificial 
                 Luk243 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 QIMYFEFQALGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYLVLIHGVKGGLISPPLSAIFTT 
               
               
                   
               
               
                 235 
                 PRT 
                 Artificial 
                 Luk244 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 NIYYWEFLENGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVAIHGVKGGFISWPLSAIFTT 
               
               
                   
               
               
                 236 
                 PRT 
                 Artificial 
                 Luk245 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 TIHYWEFRPGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVAIFGVKGGSISVPLSAIFTT 
               
               
                   
               
               
                 237 
                 PRT 
                 Artificial 
                 Luk246 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VIHYFEASPPGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYYVVIYGVKGGYISPPLSAIFTT 
               
               
                   
               
               
                 238 
                 PRT 
                 Artificial 
                 Luk247 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYHEYVQVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIYGVKGGQISDPLSAIFTT 
               
               
                   
               
               
                 239 
                 PRT 
                 Artificial 
                 Luk248 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 NIIYWEYVDVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYLVPIYGVKGGLISEPLSAIFTT 
               
               
                   
               
               
                 240 
                 PRT 
                 Artificial 
                 Luk249 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIVYWEQKFYGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYFVGIYGVKGGFISLPLSAIFTT 
               
               
                   
               
               
                 241 
                 PRT 
                 Artificial 
                 Luk250 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VIFYDEWRGVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYFVPIQGVKGGYVSDPLSAIFTT 
               
               
                   
               
               
                 242 
                 PRT 
                 Artificial 
                 Luk251 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIHYHEYQQIGEAIVLTVPGSERSYDLIGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIYGVKGGFISQPLSAIFTT 
               
               
                   
               
               
                 243 
                 PRT 
                 Artificial 
                 Luk252 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIFYLEWPAKGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKGGWISPPLSAIFTT 
               
               
                   
               
               
                 244 
                 PRT 
                 Artificial 
                 Luk253 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 NIVYWEYNPVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYFVGIYGVKGGNISKPLSAIFTT 
               
               
                   
               
               
                 245 
                 PRT 
                 Artificial 
                 Luk254 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 GIFYLEHDWRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVIIHGVKGGSISVPLSAIFTT 
               
               
                   
               
               
                 246 
                 PRT 
                 Artificial 
                 Luk255 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TILYWEYEQQGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIHGVKGGEISQPLSAIFTT 
               
               
                   
               
               
                 247 
                 PRT 
                 Artificial 
                 Luk257 LukD, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukAB binding 
                 TIIYIEHVDWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVEIYGVKGGKISAPLSAIFTT 
               
               
                   
               
               
                 248 
                 PRT 
                 Artificial 
                 Luk258 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 TIYYFESVDWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYYVYIYGVKGGWISVPLSAIFTT 
               
               
                   
               
               
                 249 
                 PRT 
                 Artificial 
                 Luk259 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 QIIYWESQYWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYIVVIHGVKGGGISDPLSAIFTT 
               
               
                   
               
               
                 250 
                 PRT 
                 Artificial 
                 Luk260 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 RIIYYEWESAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIHGVKGGFISFPLSAIFTT 
               
               
                   
               
               
                 251 
                 PRT 
                 Artificial 
                 Luk261 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 NIFYWEFQKKGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYIVIIYGVKGGFISPPLSAIFTT 
               
               
                   
               
               
                 252 
                 PRT 
                 Artificial 
                 Luk262 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 HIFYLEKTNYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYLVIIHGVKGGPISGPLSAIFTT 
               
               
                   
               
               
                 253 
                 PRT 
                 Artificial 
                 Luk263 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GIWYWEYVRNGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYFVPIYGVKGGDTSPPLSAIFTT 
               
               
                   
               
               
                 254 
                 PRT 
                 Artificial 
                 Luk264 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VIFYHEYFTVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIHGVKGGLISAPLSAIFTT 
               
               
                   
               
               
                 255 
                 PRT 
                 Artificial 
                 Luk265 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 QIIYFENEYGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVAIYGVKGGYLSVPLSAIFTT 
               
               
                   
               
               
                 256 
                 PRT 
                 Artificial 
                 Luk266 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 RIGYLENPWDGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVFIYGVKGGHISNPLSAIFTT 
               
               
                   
               
               
                 257 
                 PRT 
                 Artificial 
                 Luk267 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFI 
               
               
                   
                   
                   
                 binding FN3 
                 IHYFEYEPPGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYFVGIYGVKGGWVSEPLSAIFTT 
               
               
                   
               
               
                 258 
                 PRT 
                 Artificial 
                 Luk268 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYPEYSARGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKGGFVSEPLSAIFTT 
               
               
                   
               
               
                 259 
                 PRT 
                 Artificial 
                 Luk269 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 NIIYWEYEVAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVSIQGVKGGAISPPLSAIFTT 
               
               
                   
               
               
                 260 
                 PRT 
                 Artificial 
                 Luk270 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 QIVYFEHPSYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVGIYGVKGGEISAPLSAIFTT 
               
               
                   
               
               
                 261 
                 PRT 
                 Artificial 
                 Luk271 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 NIVYFEWAANGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYFVGIYGVKGGAISLPLSAIFTT 
               
               
                   
               
               
                 262 
                 PRT 
                 Artificial 
                 Luk272 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 NIFYWEDTLKGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYVVAIHGVKGGTISHPLSAIFTT 
               
               
                   
               
               
                 263 
                 PRT 
                 Artificial 
                 Luk273 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 VINYWEFQPAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVAIHGVKGGQISKPLSAIFTT 
               
               
                   
               
               
                 264 
                 PRT 
                 Artificial 
                 Luk274 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIIYWELVWNGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYCVPIHGVKGGLISPPLSAIFTT 
               
               
                   
               
               
                 265 
                 PRT 
                 Artificial 
                 Luk275 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS, LukD 
                 VIFYEEWQVGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 binding FN3 
                 GTEYFVAIYGVKGGAISQPLSAIFTT 
               
               
                   
                   
                   
                 domain 
                   
               
               
                   
               
               
                 266 
                 PRT 
                 Artificial 
                 Luk276 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 YIHYFEYEIRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVSIYGVKGGLISSPLSAIFTT 
               
               
                   
               
               
                 267 
                 PRT 
                 Artificial 
                 Luk277 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYLEYDQGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVTIHGVKGGYISEPLSAIFTT 
               
               
                   
               
               
                 268 
                 PRT 
                 Artificial 
                 Luk278 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 PIFYWEFAVSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYSVVIHGVKGGVISEPLSAIFTT 
               
               
                   
               
               
                 269 
                 PRT 
                 Artificial 
                 Luk279 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 QIIYFEFFIGGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 FN3 domain 
                 TEYFVVIHGVKGGDLSAPLSAIFTT 
               
               
                   
               
               
                 270 
                 PRT 
                 Artificial 
                 Luk280 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 SIIYWEFASNGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIYGVKGGEISNPLSAIFTT 
               
               
                   
               
               
                 271 
                 PRT 
                 Artificial 
                 Luk281 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYFEFQTHGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVPITGVKGGWYSDPLSAIFTT 
               
               
                   
               
               
                 272 
                 PRT 
                 Artificial 
                 Luk282 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFI 
               
               
                   
                   
                   
                 binding FN3 
                 IIYWEYRTCGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYFVEIYGVKGGNTSPPLSAIFTT 
               
               
                   
               
               
                 273 
                 PRT 
                 Artificial 
                 Luk283 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSI 
               
               
                   
                   
                   
                 LukS binding 
                 TIHYFEPHTGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVPIYGVKGGYISQPLSAIFTT 
               
               
                   
               
               
                 274 
                 PRT 
                 Artificial 
                 Luk285 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 PILYWENITTGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKGGFISGPLSAIFTT 
               
               
                   
               
               
                 275 
                 PRT 
                 Artificial 
                 Luk286 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 PIFYWEFQAAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVEIYGVKGGWTSFPLSAIFTT 
               
               
                   
               
               
                 276 
                 PRT 
                 Artificial 
                 Luk287 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 VIVYWEWQCNGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYFVFIHGVKGGITSAPLSAIFTT 
               
               
                   
               
               
                 277 
                 PRT 
                 Artificial 
                 Luk288 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIHYWEPQGIGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVGIHGVKGGWISFPLSAIFTT 
               
               
                   
               
               
                 278 
                 PRT 
                 Artificial 
                 Luk289 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFI 
               
               
                   
                   
                   
                 binding FN3 
                 IPYWEYQYAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVGIYGVKGGSISEPLSAIFTT 
               
               
                   
               
               
                 279 
                 PRT 
                 Artificial 
                 Luk290 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYIEPQFEGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 FN3 domain 
                 TEYIVVIHGVKGGYISKPLSAIFTT 
               
               
                   
               
               
                 280 
                 PRT 
                 Artificial 
                 Luk291 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 NIIYWEYDPHGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYIVSIYGVKGGYISPPLSAIFTT 
               
               
                   
               
               
                 281 
                 PRT 
                 Artificial 
                 Luk292 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIEYWEWIDKGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVGIYGVKGGYISWPLSAIFTT 
               
               
                   
               
               
                 282 
                 PRT 
                 Artificial 
                 Luk293 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS, LukD, 
                 SILYHEWSGWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 LukAB binding 
                 PGTEYFVFIHGVKGGYISPPLSAIFTT 
               
               
                   
                   
                   
                 FN3 domain 
                   
               
               
                   
               
               
                 283 
                 PRT 
                 Artificial 
                 Luk294 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 QILYWETAKSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVEIYGVKGGWISWPLSAIFTT 
               
               
                   
               
               
                 284 
                 PRT 
                 Artificial 
                 Luk296 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 TIHYYEFKYQGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVVIHGVKGGFISPPLSAIFTT 
               
               
                   
               
               
                 285 
                 PRT 
                 Artificial 
                 Luk298 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIIYLEGNWSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVSIYGVKGGFISEPLSAIFTT 
               
               
                   
               
               
                 286 
                 PRT 
                 Artificial 
                 Luk299 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS, LukAB 
                 KIFYWEWPHSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 binding FN3 
                 GTEYFVAIHGVKGGWISKPLSAIFTT 
               
               
                   
                   
                   
                 domain 
                   
               
               
                   
               
               
                 287 
                 PRT 
                 Artificial 
                 Luk300 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 TISYWEYAGYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVGIHGVKGGWISKPLSAIFTT 
               
               
                   
               
               
                 288 
                 PRT 
                 Artificial 
                 Luk301 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 HISYWEYYARGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYFVGIYGVKGGVISPPLSAIFTT 
               
               
                   
               
               
                 289 
                 PRT 
                 Artificial 
                 Luk302 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 KIWYLETGFRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVPIYGVKGGYISQPLSAIFTT 
               
               
                   
               
               
                 290 
                 PRT 
                 Artificial 
                 Luk303 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 NIQYWEWNLGGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYFVAIYGVKGGAISDPLSAIFTT 
               
               
                   
               
               
                 291 
                 PRT 
                 Artificial 
                 Luk304 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WIGYTELYEFGEAISLLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYSVAIAGVKGGAYSHPLHALFTT 
               
               
                   
               
               
                 292 
                 PRT 
                 Artificial 
                 Luk305 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 YIKYAEHVVWGEAIDLLVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYEVGIAGVKGGTVSVPLSARFTT 
               
               
                   
               
               
                 293 
                 PRT 
                 Artificial 
                 Luk306 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFI 
               
               
                   
                   
                   
                 LukS binding 
                 ILYDEIWPSGEAISLGVPGSERSYDLTGLKPGT 
               
               
                   
                   
                   
                 FN3 domain 
                 EYFVAIHGVKGGNISDPLDAKFTT 
               
               
                   
               
               
                 294 
                 PRT 
                 Artificial 
                 Luk307 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYTESRYYGEAIDLLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYHVRISGVKGGAFSTPLWAAATT 
               
               
                   
               
               
                 295 
                 PRT 
                 Artificial 
                 Luk308 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WIGYGERLRFGEAIDLLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYHVGISGVKGGWFSNPLRAIFTT 
               
               
                   
               
               
                 296 
                 PRT 
                 Artificial 
                 Luk309 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 KIFYLESDWEGEAIALWVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYFVFIHGVKGGYISIPLHANFTT 
               
               
                   
               
               
                 297 
                 PRT 
                 Artificial 
                 Luk310 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYTETAKWGEAITLLVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYRVGIGGVKGGGWSWPLDAIFTT 
               
               
                   
               
               
                 298 
                 PRT 
                 Artificial 
                 Luk311 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WISYVEPDDGEAIELLVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYIVQIDGVKGGTTSVPLNARFTT 
               
               
                   
               
               
                 299 
                 PRT 
                 Artificial 
                 Luk312 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WIGYSEYPEYGEAIDLVVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYRVGITGVKGGWISKPLNATFTT 
               
               
                   
               
               
                 300 
                 PRT 
                 Artificial 
                 Luk313 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYNEIGKWGEAIDLIVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYAVGIDGVKGGSISEPLPASFTT 
               
               
                   
               
               
                 301 
                 PRT 
                 Artificial 
                 Luk314 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIFYTEFNFKGEAIPLDVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVSIHGVKGGEISPPLEALFTT 
               
               
                   
               
               
                 302 
                 PRT 
                 Artificial 
                 Luk315 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WISYQEPDEIGEAIELIVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYFVQIDGVKGGTWSIPLNAYFTT 
               
               
                   
               
               
                 303 
                 PRT 
                 Artificial 
                 Luk317 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYHEFPTWGEAIDLLVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYQVRISGVKGGTTSQPLQAAAT 
               
               
                   
               
               
                 304 
                 PRT 
                 Artificial 
                 Luk318 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS, HlgA 
                 WIGYHETVGFGEAIALLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 binding FN3 
                 GTEYAVAIDGVKGGWFSHPLVAYFTT 
               
               
                   
                   
                   
                 domain 
                   
               
               
                   
               
               
                 305 
                 PRT 
                 Artificial 
                 Luk319 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYFERFNWGEAIDLLVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYQVQIDGVKGGDISIPLSARFTT 
               
               
                   
               
               
                 306 
                 PRT 
                 Artificial 
                 Luk320 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYSEWEQLGEAIDLIVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYQVGIAGVKGGSSSFPLGAEFTT 
               
               
                   
               
               
                 307 
                 PRT 
                 Artificial 
                 Luk321 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WIGYQEAATWGEAIDLSVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYHVGIVGVKGGGVSTPLVAPFTT 
               
               
                   
               
               
                 308 
                 PRT 
                 Artificial 
                 Luk322 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYYESHRGGEAIDLLVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYTVGITGVKGGTISYPLHAIFTT 
               
               
                   
               
               
                 309 
                 PRT 
                 Artificial 
                 Luk323 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTEPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WIAYPEPGFQGEAISLLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYEVQIAGVKGGHVSWPLVATFTT 
               
               
                   
               
               
                 310 
                 PRT 
                 Artificial 
                 Luk324 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIAYEEVRAEGEAIELLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYVVGIDGVKGGGFSSPLVAHFTT 
               
               
                   
               
               
                 311 
                 PRT 
                 Artificial 
                 Luk326 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WIAYYERTQQGEAIELLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVGIDGVKGGEVSQPLKAHFTT 
               
               
                   
               
               
                 312 
                 PRT 
                 Artificial 
                 Luk327 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIFYLEWLYHGEAIKLYVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYYVVIHGVKGGFVSTPLFATFTT 
               
               
                   
               
               
                 313 
                 PRT 
                 Artificial 
                 Luk329 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukF binding 
                 WIGYWEGIGYGEAITLLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYNVGIDGVKGGDFSTPLWARFTT 
               
               
                   
               
               
                 314 
                 PRT 
                 Artificial 
                 Luk330 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYHEFSTYGEAIDLLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYTVKIAGVKGGATSVPLVATFTT 
               
               
                   
               
               
                 315 
                 PRT 
                 Artificial 
                 Luk331 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS, LukD 
                 AIFYFEDDERGEAIVLNVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 binding FN3 
                 GTEYHVIIHGVKGGQISSPLYATFTT 
               
               
                   
                   
                   
                 domain 
                   
               
               
                   
               
               
                 316 
                 PRT 
                 Artificial 
                 Luk332 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS, LukAB 
                 WIAYGEWEYPGEAIELLVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 binding FN3 
                 PGTEYHVGIDGVKGGRVSYPLRAQFTT 
               
               
                   
                   
                   
                 domain 
                   
               
               
                   
               
               
                 317 
                 PRT 
                 Artificial 
                 Luk333 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 RIHYWEGLFVGEAIVLSVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYAVPIYGVKGGSISKPLYALFTT 
               
               
                   
               
               
                 318 
                 PRT 
                 Artificial 
                 Luk334 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 HIGYHEAEGFGEAIALLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYPVGISGVKGGFVSFPLWARFTT 
               
               
                   
               
               
                 319 
                 PRT 
                 Artificial 
                 Luk335 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYNEIVNHGEAIDLVVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYRVSIGGVKGGHWSVPLWARFTT 
               
               
                   
               
               
                 320 
                 PRT 
                 Artificial 
                 Luk336 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYHEWIGPGEAISLLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYWVGIAGVKGGWSSRPLSATFTT 
               
               
                   
               
               
                 321 
                 PRT 
                 Artificial 
                 Luk337 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYEEPLYFGEAIDLLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYRVHIGGVKGGRVSIPLEAEFTT 
               
               
                   
               
               
                 322 
                 PRT 
                 Artificial 
                 Luk338 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIAYEEDNAQGEAIELLVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYDVKIDGVKGGRVSTPLVARFTT 
               
               
                   
               
               
                 323 
                 PRT 
                 Artificial 
                 Luk339 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 VIFYWEGQWNGEAILLDVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYIVPIHGVKGGWISLPLVATFTT 
               
               
                   
               
               
                 324 
                 PRT 
                 Artificial 
                 Luk340 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYHESPYAGEAIDLVVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYAVGIAGVKGGGYSIPLRAIFTT 
               
               
                   
               
               
                 325 
                 PRT 
                 Artificial 
                 Luk342 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYSEPTIYGEAIDLLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVGITGVKGGWNSRPLSAIFTT 
               
               
                   
               
               
                 326 
                 PRT 
                 Artificial 
                 Luk343 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIFYTETHWFGEAINLPVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYGVIIHGVKGGYISDPLWAAFTT 
               
               
                   
               
               
                 327 
                 PRT 
                 Artificial 
                 Luk344 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WISYVEPVFSGEAIELLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYIVGIGGVKGGGWSIPLEAHFTT 
               
               
                   
               
               
                 328 
                 PRT 
                 Artificial 
                 Luk345 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 SIFYIEAKFRGEAIRLGVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYFVWIHGVKGGEISDPLEAPFTT 
               
               
                   
               
               
                 329 
                 PRT 
                 Artificial 
                 Luk346 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIAYYEIVGWGEAITLLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTKYVVLIDGVKGGLLSQPLHAEFAT 
               
               
                   
               
               
                 330 
                 PRT 
                 Artificial 
                 Luk347 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYHETTRFGEAIDLLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYVVAIQGVKGGHVSQPLRAPFTT 
               
               
                   
               
               
                 331 
                 PRT 
                 Artificial 
                 Luk348 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 SIIYLEASFRGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYFVSIYGVKGGHFSPPLDAIFTT 
               
               
                   
               
               
                 332 
                 PRT 
                 Artificial 
                 Luk349 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WIGYREWIQWGEAISLLVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYRVGITGVNGGVTSVPLHAKFTT 
               
               
                   
               
               
                 333 
                 PRT 
                 Artificial 
                 Luk350 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukF binding 
                 WIAYHEGLSWGEAIDLLVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYTVSIDGVKGGYTSEPLRASFTT 
               
               
                   
               
               
                 334 
                 PRT 
                 Artificial 
                 Luk351 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYDETLTYGEAITLLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYTVGIDGVKGGRNSVPLKATFTT 
               
               
                   
               
               
                 335 
                 PRT 
                 Artificial 
                 Luk353 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYHEPRAWGEAIDLLVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYLVGIGGVKGGKQSKPLVAKFTT 
               
               
                   
               
               
                 336 
                 PRT 
                 Artificial 
                 Luk354 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYTEQKNHGEAIDLLVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYEVNIAGVKGGGWSIPLNAWFTT 
               
               
                   
               
               
                 337 
                 PRT 
                 Artificial 
                 Luk355 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 KIVYVEIHYRGEAIHLSVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYHVVIHGVKGGGISLPLDAPFTT 
               
               
                   
               
               
                 338 
                 PRT 
                 Artificial 
                 Luk356 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDATFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYSEDQRTGEAIDLVVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYRVAIAGVKGGYISQPLSANFTT 
               
               
                   
               
               
                 339 
                 PRT 
                 Artificial 
                 Luk357 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 TIHYFESLLTGEAISLVVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYLVPIYGVKGGFISQPLIAIFTT 
               
               
                   
               
               
                 340 
                 PRT 
                 Artificial 
                 Luk358 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AINYYEYYPAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIYGVKGGYISPPLSAIFTT 
               
               
                   
               
               
                 341 
                 PRT 
                 Artificial 
                 Luk361 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 SIYYYEYYANGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVAIYGVKGGYVSDPLSAIFTT 
               
               
                   
               
               
                 342 
                 PRT 
                 Artificial 
                 Luk362 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 PIYYLEYSFTGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYAVYIYGVKGGWISDPLSAIFTT 
               
               
                   
               
               
                 343 
                 PRT 
                 Artificial 
                 Luk363 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 RIYYYEWASYGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYFVGIYGVKGGHISRPLSAIFTT 
               
               
                   
               
               
                 344 
                 PRT 
                 Artificial 
                 Luk364 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 RIFYHEYSYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYLVIIHSVKGGSVSSPLSAIFTT 
               
               
                   
               
               
                 345 
                 PRT 
                 Artificial 
                 Luk365 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIYYYEYWYGGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYWVGIYGVKGGYISSPLSAIFTT 
               
               
                   
               
               
                 346 
                 PRT 
                 Artificial 
                 Luk366 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIFYYEFNWGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYWVGIYGVKGGYISYPLSAIFTT 
               
               
                   
               
               
                 347 
                 PRT 
                 Artificial 
                 Luk368 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIYYFESINLGDAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYYVYIYGVKGGYISYPLSAIFTT 
               
               
                   
               
               
                 348 
                 PRT 
                 Artificial 
                 Luk369 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 RIFYYEYGGGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYHVGIYGVKGGYISPPLSAIFTT 
               
               
                   
               
               
                 349 
                 PRT 
                 Artificial 
                 Luk370 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 SIYYFEYWTYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYYVYIYGVKGGYISDPLSAIFTT 
               
               
                   
               
               
                 350 
                 PRT 
                 Artificial 
                 Luk371 HlgC 
                 LPAPKNLVVSRVIEDSARLSWTAPDAAFDSFT 
               
               
                   
                   
                   
                 binding FN3 
                 IFYYEYDSGEAIVLTVPGSERSYDLTGLKPGT 
               
               
                   
                   
                   
                 domain 
                 EYTVAIFGVKGGYISAPLSAIFTT 
               
               
                   
               
               
                 351 
                 PRT 
                 Artificial 
                 Luk372 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 LIGYEEYANAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVFIYGVKGGYYSYPLSAIFTT 
               
               
                   
               
               
                 352 
                 PRT 
                 Artificial 
                 Luk373 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 HIYYFEYINLGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVYIHGVKGGFVSDPLSAIFTT 
               
               
                   
               
               
                 353 
                 PRT 
                 Artificial 
                 Luk374 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 VIEYWEYRLAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVGIYGVKGGAVSLPLSAIFTT 
               
               
                   
               
               
                 354 
                 PRT 
                 Artificial 
                 Luk375 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 HIDYWEYVFLGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVSITGVKGGRYSYPLSAIFTT 
               
               
                   
               
               
                 355 
                 PRT 
                 Artificial 
                 Luk376 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIPYYEYWWSGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYWVGIYGVKGGYISSPLSAIFTT 
               
               
                   
               
               
                 356 
                 PRT 
                 Artificial 
                 Luk377 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WINYWEYYPHGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYFVGIYGVKGGSYSHPLSAIFTT 
               
               
                   
               
               
                 357 
                 PRT 
                 Artificial 
                 Luk378 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIFYHEDAYTGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKGGFLSRPLSAIFTT 
               
               
                   
               
               
                 358 
                 PRT 
                 Artificial 
                 Luk379 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 YILYHEYEYSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVAIYGVKGGLYSAPLSAIFTT 
               
               
                   
               
               
                 359 
                 PRT 
                 Artificial 
                 Luk380 HlgC, 
                 LPAPKNLVVSRVNEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 DIVYGVGEAIVLTVPGSERSYDLTGLKPGTEY 
               
               
                   
                   
                   
                 FN3 domain 
                 YVPIAGVKGGGVSWPLSAIFTT 
               
               
                   
               
               
                 360 
                 PRT 
                 Artificial 
                 Luk381 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 RIYYYEYYKYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIYGVKGGEISDPLSAIFTT 
               
               
                   
               
               
                 361 
                 PRT 
                 Artificial 
                 Luk382 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GIIYDETAQYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYLVPIHGVKGGTISYPLSAIFTT 
               
               
                   
               
               
                 362 
                 PRT 
                 Artificial 
                 Luk390 LukD 
                 LPAPKNLVVSRVTEDSARLSWTYIHHGFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVVWGYWNPTQYSNPLSAIFTT 
               
               
                   
               
               
                 363 
                 PRT 
                 Artificial 
                 Luk394 LukE 
                 LPAPKNLVVSRVTEDSARLSWDQYRLNFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVNWGYFLAPEISNPLSAIFTT 
               
               
                   
               
               
                 364 
                 PRT 
                 Artificial 
                 Luk399 LukE 
                 LPAPKNLVVSRVTEDSARLSWPGQTRKFNIF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVVGIFLTFGSNPLSAIFTT 
               
               
                   
               
               
                 365 
                 PRT 
                 Artificial 
                 Luk409 LukD 
                 LPAPKNLVVSRVTEDSARLSWKYTLYQHYF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVLAWWSFGSNPLSAIFTT 
               
               
                   
               
               
                 366 
                 PRT 
                 Artificial 
                 Luk412 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GIGYLEYPWYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVDIYGVKGGWWSYPLSAIFTT 
               
               
                   
               
               
                 367 
                 PRT 
                 Artificial 
                 Luk414 LukE 
                 LPAPNLLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WIDYIETYYYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYLVDIYGVKGGWYSLPLSAIFTT 
               
               
                   
               
               
                 368 
                 PRT 
                 Artificial 
                 Luk415 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 EISYTEYGISGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYFVDIYGVKGGYLSYPLSAIFTT 
               
               
                   
               
               
                 369 
                 PRT 
                 Artificial 
                 Luk417 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 NIDYFEYYEFGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVDIYGVKGGSWSLPLSAIFTT 
               
               
                   
               
               
                 370 
                 PRT 
                 Artificial 
                 Luk420 LukAB 
                 LPAPKNLVVSRVTEDSARLSWWLGRFNFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVKQWIISEESLSNPLSAIFTT 
               
               
                   
               
               
                 371 
                 PRT 
                 Artificial 
                 Luk428 LukF 
                 LPAPKNLVVSRVTEDSARLSWGIKEETIIFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVNIIELHLWSNPLSAIFTT 
               
               
                   
               
               
                 372 
                 PRT 
                 Artificial 
                 Luk438 HlgC 
                 LPAPKNLVVSRVTEDSARLSWWRKPKRWRH 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                 domain 
                 GLKPGTEYTVSIYGVAPDTPTPVIISNPLSAIFTT 
               
               
                   
               
               
                 373 
                 PRT 
                 Artificial 
                 Luk445 HlgA 
                 LPAPKNLVVSRVTEDSARLSWEVNTKTSNKF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVGYWLTNVVLASNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 374 
                 PRT 
                 Artificial 
                 Luk447 LukD 
                 LPAPKNLVVSRVTEDSARLSWGIDDYFVHFF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVSIHFEFTTYSRSNPLSAIFTT 
               
               
                   
               
               
                 375 
                 PRT 
                 Artificial 
                 Luk449 LukE, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 HlgA binding 
                 DISYDEYPEFGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVDIIGVKGGEISLPLSAIFTT 
               
               
                   
               
               
                 376 
                 PRT 
                 Artificial 
                 Luk452 LukE, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 HlgA binding 
                 NIHYAEYPDFGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYIVDIWGVKGGLGSWPLSAIFTT 
               
               
                   
               
               
                 377 
                 PRT 
                 Artificial 
                 Luk460 LukF 
                 LPAPKNLVVSRVTEDSARLSWIWGGESFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVGQIGFIYRPEGSNPLSAIFTT 
               
               
                   
               
               
                 378 
                 PRT 
                 Artificial 
                 Luk461 LukF 
                 LPAPKNLVVSRVTEDSARLSWLGPTATVFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVWSLLHHRFSNPLSAIFTT 
               
               
                   
               
               
                 379 
                 PRT 
                 Artificial 
                 Luk462 LukF 
                 LPAPKNLVVSRVTEDSARLSWHPIWVDFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVRGDGFEVILHSNPLSAIFTT 
               
               
                   
               
               
                 380 
                 PRT 
                 Artificial 
                 Luk463 LukF 
                 LPAPKNLVVSRVTEDSARLSWKWFKTTAFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVLHASEIHQWESSNPLSAIFTT 
               
               
                   
               
               
                 381 
                 PRT 
                 Artificial 
                 Luk464 LukF 
                 LPAPKNLVVSRVTEDSARLSWWWPVAPFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVGAINYVYFPTWSNPLSAIFTT 
               
               
                   
               
               
                 382 
                 PRT 
                 Artificial 
                 Luk465 LukF 
                 LPAPKNLVVSRVTEDSARLSWVTDPGTNFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVWSWVHSRYSNPLSAIFTT 
               
               
                   
               
               
                 383 
                 PRT 
                 Artificial 
                 Luk467 LukF 
                 LPAPKNLVVSRVTEDSARLSWPWLQYPFFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVGYLDWHIFQLASNPLSAIFTT 
               
               
                   
               
               
                 384 
                 PRT 
                 Artificial 
                 Luk468 LukF 
                 LPAPKNLVVSRVTEDSARLSWQPSHGEFANF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVQPWYRGGHIYDFSNPLS 
               
               
                   
                   
                   
                   
                 AIFTT 
               
               
                   
               
               
                 385 
                 PRT 
                 Artificial 
                 Luk470 LukF 
                 LPAPKNLVVSRVTEDSARLSWINYSDPDFFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVYHWWYRGTPVVSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 386 
                 PRT 
                 Artificial 
                 Luk473 LukF, 
                 LPAPKNLVVSRVTEDSARLSWLEGFFPQPLFD 
               
               
                   
                   
                   
                 LukD, LukAB 
                 SFLIQYLESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 binding FN3 
                 KPGTEYTVSIYGVPWYHHRWWFASNPLSAIF 
               
               
                   
                   
                   
                 domain 
                 TT 
               
               
                   
               
               
                 387 
                 PRT 
                 Artificial 
                 Luk475 LukF 
                 LPAPKNLVVSRVTEDSARLSWKQHTNTHYQ 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYQESEKVGEAIVLTVPVSERSYDLT 
               
               
                   
                   
                   
                 domain 
                 GLKPGTEYTVSIYGVRWIDNHLKFNVHSNPL 
               
               
                   
                   
                   
                   
                 SAIFTT 
               
               
                   
               
               
                 388 
                 PRT 
                 Artificial 
                 Luk476 LukF, 
                 LPAPKNLVVSRVTEDSARLSWLEGFFPQPLFD 
               
               
                   
                   
                   
                 LukS, LukD, 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 LukE, LukAB, 
                 KPGTEYTVSIYGVPWYHHRWWFASNPLSAIF 
               
               
                   
                   
                   
                 HlgB, HlgC 
                 TT 
               
               
                   
                   
                   
                 binding FN3 
                   
               
               
                   
                   
                   
                 domain 
                   
               
               
                   
               
               
                 389 
                 PRT 
                 Artificial 
                 Luk478 HlgC 
                 LPAPKNLVVSRVTEDSARLSWLEGFFPQPLFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVASRWHSFPVTTSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 390 
                 PRT 
                 Artificial 
                 Luk479 LukF, 
                 LPAPKNLVVSRVTEDSARLSWLEGFFPQPLFD 
               
               
                   
                   
                   
                 LukD binding 
                 SFLIQYQESEKVGEAIVLTVPGSERSYGLTGL 
               
               
                   
                   
                   
                 FN3 domain 
                 KPGTEYTVSIYGVPWYHHRWWFASNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 391 
                 PRT 
                 Artificial 
                 Luk483 LukF 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 RIFYYERFTWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYPVHIWGVKGGIDSRPLSAIFTT 
               
               
                   
               
               
                 392 
                 PRT 
                 Artificial 
                 Luk486 LukD, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukAB binding 
                 AIRYGEETVHGEAIALIVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYPVAIAGVKGGTWSIPLSAIFTT 
               
               
                   
               
               
                 393 
                 PRT 
                 Artificial 
                 Luk487 LukF 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIHYLEFHYAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVVIYGVKGDLISGPLSAIFTT 
               
               
                   
               
               
                 394 
                 PRT 
                 Artificial 
                 Luk498 LukD 
                 LPAPKNLVVSRVTEDSARLSWLPGPFRRFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVVNHEWYHAFSNPLSAIFTT 
               
               
                   
               
               
                 395 
                 PRT 
                 Artificial 
                 Luk499 LukS 
                 LPAPKNLVVSRVTEDSARLSWIGRELIWFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVVTHEWRSEFSNPLSAIFTT 
               
               
                   
               
               
                 396 
                 PRT 
                 Artificial 
                 Luk500 LukS 
                 LPAPKNLVVSRVTEDSARLSWKKPSYYIFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVVNHEWYHAFSNPLSAIFTT 
               
               
                   
               
               
                 397 
                 PRT 
                 Artificial 
                 Luk505 LukS 
                 LPAPKNLVVSRVTEDSARLSWQQAARWFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVVTREWFHSFSNPLSAIFTT 
               
               
                   
               
               
                 398 
                 PRT 
                 Artificial 
                 Luk507 LukS 
                 LPAPKNLVVSRVTEDSARLSWQHHGFRLFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVFTHEWFHEFSNPLSAIFTT 
               
               
                   
               
               
                 399 
                 PRT 
                 Artificial 
                 Luk510 LukS 
                 LPAPKNLVVSRVTEDSARLSWDEYSVTTWW 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                 domain 
                 GLKPGTEYTVSIYGVNELYRPWVASNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 400 
                 PRT 
                 Artificial 
                 Luk513 LukS 
                 LPAPKNLVVSRVTEDSARLSWWTGGWRRNP 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                 domain 
                 GLKPGTEYTVSIYGVQLHRTIIAGESNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 401 
                 PRT 
                 Artificial 
                 Luk516 LukS 
                 LPAPKNLVVSRVTEDSARLSWVGANSRHWF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVAVSEWFHSFSNPLSAIFTT 
               
               
                   
               
               
                 402 
                 PRT 
                 Artificial 
                 Luk517 LukS 
                 LPAPKNLVVSRVTEDSARLSWVNHLEGEAW 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                 domain 
                 GLKPGTEYTVSIYGVQTHEWWHKFSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 403 
                 PRT 
                 Artificial 
                 Luk519 LukS 
                 LPAPKNLVVSRVTEDSARLSWDLEHHNYHY 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                 domain 
                 GLKPGTEYTVSIYGVWFLQPAIHPPSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 404 
                 PRT 
                 Artificial 
                 Luk520 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIFYYEYWSNGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYWVGIHGVKGGLISHPLSAIFTT 
               
               
                   
               
               
                 405 
                 PRT 
                 Artificial 
                 Luk521 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFI 
               
               
                   
                   
                   
                 LukS binding 
                 ITYEEATLNGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 FN3 domain 
                 TEYTVGITGVKGGLGSYPLSAIFTT 
               
               
                   
               
               
                 406 
                 PRT 
                 Artificial 
                 Luk522 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYLEQRFQGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYAVIIHGVKGGWISFPLSAIFTT 
               
               
                   
               
               
                 407 
                 PRT 
                 Artificial 
                 Luk523 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 NIPYLERQLYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYTVTIGGVKGGAPSRPLSAIFTT 
               
               
                   
               
               
                 408 
                 PRT 
                 Artificial 
                 Luk524 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 FIFYLEYAHPGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYHVIIHGVKGGLISEPLSAIFTT 
               
               
                   
               
               
                 409 
                 PRT 
                 Artificial 
                 Luk525 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 YIFYWESVTGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYIVIIHGVKGGLISDPLSAIFTT 
               
               
                   
               
               
                 410 
                 PRT 
                 Artificial 
                 Luk526 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 PIFYDEHHQWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYWVAIYGVKGGYYSSPLSAIFTT 
               
               
                   
               
               
                 411 
                 PRT 
                 Artificial 
                 Luk527 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 HIFYWEPNEVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVEIYGVKGGEISYPLSAIFTT 
               
               
                   
               
               
                 412 
                 PRT 
                 Artificial 
                 Luk528 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIDYREETPKGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYWVIILGVKGGGDSFPLSAIFTT 
               
               
                   
               
               
                 413 
                 PRT 
                 Artificial 
                 Luk529 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GIYYGEWNPKGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYWVIISGVKGGPQSIPLSAIFTT 
               
               
                   
               
               
                 414 
                 PRT 
                 Artificial 
                 Luk530 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukD binding 
                 GIFYHEIEENGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 FN3 domain 
                 TEYFVAIHGVKGGVISTPLSAIFTT 
               
               
                   
               
               
                 415 
                 PRT 
                 Artificial 
                 Luk531 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 RIFYYELYHAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVIIHGVKGGQISLPLSAIFTT 
               
               
                   
               
               
                 416 
                 PRT 
                 Artificial 
                 Luk532 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYLELESSGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 FN3 domain 
                 TEYNVIIHGVKGGFISSPLSAIFTT 
               
               
                   
               
               
                 417 
                 PRT 
                 Artificial 
                 Luk533 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 PIFYVELRNPGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYHVVIHGVKGGFISHPLSAIFTT 
               
               
                   
               
               
                 418 
                 PRT 
                 Artificial 
                 Luk534 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYTEWNEFGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVIIHGVKGGQISVPLSAIFTT 
               
               
                   
               
               
                 419 
                 PRT 
                 Artificial 
                 Luk535 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VIFYLEPTTQGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVIIHGVKGGPVSGPLSAIFTT 
               
               
                   
               
               
                 420 
                 PRT 
                 Artificial 
                 Luk536 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIAYIETDGWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVPIHGVKGGYISQPLSAIFTT 
               
               
                   
               
               
                 421 
                 PRT 
                 Artificial 
                 Luk537 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIFYHEHKIRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVIIHGVKGGYISLPLSAIFTT 
               
               
                   
               
               
                 422 
                 PRT 
                 Artificial 
                 Luk538 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 PIFYLERANRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVIIHGVKGGTISDPLSAIFTT 
               
               
                   
               
               
                 423 
                 PRT 
                 Artificial 
                 Luk539 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIFYLETLYHGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVVIHGVKGGHSSPLSAIFTT 
               
               
                   
               
               
                 424 
                 PRT 
                 Artificial 
                 Luk540 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 HIEYPEDTEQGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYNVHITGVKGGSKSAPLSAIFTT 
               
               
                   
               
               
                 425 
                 PRT 
                 Artificial 
                 Luk541 LukS, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukD binding 
                 NILYTETEQSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYIVIIHGVKGGFISGPLSAIFTT 
               
               
                   
               
               
                 426 
                 PRT 
                 Artificial 
                 Luk542 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 TIFYPEFRGDGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYGVIIHGVKGGGDSNPLSAIFTT 
               
               
                   
               
               
                 427 
                 PRT 
                 Artificial 
                 Luk543 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIFYTETFHYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVVIHGVKGGDISAPLSAIFTT 
               
               
                   
               
               
                 428 
                 PRT 
                 Artificial 
                 Luk544 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIHYLEEFWLGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIYGVKGGFISVPLSAIFTT 
               
               
                   
               
               
                 429 
                 PRT 
                 Artificial 
                 Luk545 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VIAYIEERWSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVLIHGVKGGFISNPLSAIFTT 
               
               
                   
               
               
                 430 
                 PRT 
                 Artificial 
                 Luk546 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 SIYYGEWPHGGEAIVLTVPGSERSYDLTSLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVLIIGVKGGQLSHPLSAIFTT 
               
               
                   
               
               
                 431 
                 PRT 
                 Artificial 
                 Luk547 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYLESSGTGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 FN3 domain 
                 TEYLVIIHGVKGGRISNPLSAIFTT 
               
               
                   
               
               
                 432 
                 PRT 
                 Artificial 
                 Luk548 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS, LukD 
                 AIYYGEWHPDGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 binding FN3 
                 PGTEYWVFILGVKGGQNSQPLSAIFTT 
               
               
                   
                   
                   
                 domain 
                   
               
               
                   
               
               
                 433 
                 PRT 
                 Artificial 
                 Luk549 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYAESGNWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVFIWGVKGGHESHPLSAIFTT 
               
               
                   
               
               
                 434 
                 PRT 
                 Artificial 
                 Luk550 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIFYAETDTKGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVIIHGVKGGSISVPLSAIFTT 
               
               
                   
               
               
                 435 
                 PRT 
                 Artificial 
                 Luk551 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 RIFYQEYSNHGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVPIYGVKGGFISRPLSAIFTT 
               
               
                   
               
               
                 436 
                 PRT 
                 Artificial 
                 Luk552 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 QIFYDENLWLGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIHGVKGGFISQPLSAIFTT 
               
               
                   
               
               
                 437 
                 PRT 
                 Artificial 
                 Luk553 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 HIFYAEHEKWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYWVAIHGVKGGHISRPLSAIFTT 
               
               
                   
               
               
                 438 
                 PRT 
                 Artificial 
                 Luk554 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 SIFYLETFRRGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 FN3 domain 
                 TEYLVIIHGVKGGYVSDPLSAIFTT 
               
               
                   
               
               
                 439 
                 PRT 
                 Artificial 
                 Luk555 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 SIFYPETNYQGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVVIHGVKGGYISDPLSAIFTT 
               
               
                   
               
               
                 440 
                 PRT 
                 Artificial 
                 Luk556 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIFYIEEETNGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 FN3 domain 
                 TEYQVIIHGVKGGFISLPLSAIFTT 
               
               
                   
               
               
                 441 
                 PRT 
                 Artificial 
                 Luk557 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VIFYPEVNFRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVIIHGVKGGYISTPLSAIFTT 
               
               
                   
               
               
                 442 
                 PRT 
                 Artificial 
                 Luk558 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIFYHEWWKSGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYHVVIHGVKGGHISTPLSAIFTT 
               
               
                   
               
               
                 443 
                 PRT 
                 Artificial 
                 Luk559 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIHYPETRPTGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIYGVKGGWISPPLSAIFTT 
               
               
                   
               
               
                 444 
                 PRT 
                 Artificial 
                 Luk560 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 HIFYIEHVQVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVIIHGVKGGIISPPLSAIFTT 
               
               
                   
               
               
                 445 
                 PRT 
                 Artificial 
                 Luk561 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYYPELYFHGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYLVVIHGVKGGFISPPLSAIFTT 
               
               
                   
               
               
                 446 
                 PRT 
                 Artificial 
                 Luk562 LukS, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukAB binding 
                 AIFYKEYTHGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYWVIIHSVKGGSISYPLSAIFTT 
               
               
                   
               
               
                 447 
                 PRT 
                 Artificial 
                 Luk563 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 QIFYPEHYQDGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVVIHGVKGGWISSPLSAIFTT 
               
               
                   
               
               
                 448 
                 PRT 
                 Artificial 
                 Luk564 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYIEFRYPGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 FN3 domain 
                 TEYFVAIHGVKGGYISDPLSAIFTT 
               
               
                   
               
               
                 449 
                 PRT 
                 Artificial 
                 Luk565 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 HIFYLETWGSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKGGLISSPLSAIFTT 
               
               
                   
               
               
                 450 
                 PRT 
                 Artificial 
                 Luk566 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIFYYEHADAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVIIHGVKGGYISKPLSAIFTT 
               
               
                   
               
               
                 451 
                 PRT 
                 Artificial 
                 Luk567 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIFYQEDSDHGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIHGVKGGTISKPLSAIFTT 
               
               
                   
               
               
                 452 
                 PRT 
                 Artificial 
                 Luk568 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 RIFYIEEHDVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYIVIIHGVKGGYISDPLSAIFTT 
               
               
                   
               
               
                 453 
                 PRT 
                 Artificial 
                 Luk569 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TILYPETQTIGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 FN3 domain 
                 TEYFVGIHGVKGGIISDPLSAIFTT 
               
               
                   
               
               
                 454 
                 PRT 
                 Artificial 
                 Luk570 LukS, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFI 
               
               
                   
                   
                   
                 LukD, LukAB 
                 IYYGEWREHGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 binding FN3 
                 GTEYFVLIQGVKGGQTSGPLSAIFTT 
               
               
                   
                   
                   
                 domain 
                   
               
               
                   
               
               
                 455 
                 PRT 
                 Artificial 
                 Luk571 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 KIFYLEPKENGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVIITGVKGGFISEPLSAIFTT 
               
               
                   
               
               
                 456 
                 PRT 
                 Artificial 
                 Luk572 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIHYDEWENGGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYWVIIIGVKGGVRSNPLSAIFTT 
               
               
                   
               
               
                 457 
                 PRT 
                 Artificial 
                 Luk575 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 PIFYVEIPQPGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 FN3 domain 
                 TEYFVIIHGVKGGGISDPLSAIFTT 
               
               
                   
               
               
                 458 
                 PRT 
                 Artificial 
                 Luk576 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VILYHEYWASGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKGGFLSDPLSAIFTT 
               
               
                   
               
               
                 459 
                 PRT 
                 Artificial 
                 Luk577 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 HIFYCEHWTSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIHGVKGGEISAPLSAIFTT 
               
               
                   
               
               
                 460 
                 PRT 
                 Artificial 
                 Luk578 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYQEHLGYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYVVVIHGVKGGWISSPLSAIFTT 
               
               
                   
               
               
                 461 
                 PRT 
                 Artificial 
                 Luk579 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIIYEETANGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKGGHISSPLSAIFTT 
               
               
                   
               
               
                 462 
                 PRT 
                 Artificial 
                 Luk580 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS, LukAB 
                 QIFYPETQKYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 binding FN3 
                 GTEYFVVIHGVKGGFISSPLSAIFTT 
               
               
                   
                   
                   
                 domain 
                   
               
               
                   
               
               
                 463 
                 PRT 
                 Artificial 
                 Luk581 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VIFYGEYENGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVIIVGVKGGFDSKPLSAIFTT 
               
               
                   
               
               
                 464 
                 PRT 
                 Artificial 
                 Luk582 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 NIFYHETVDKGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVVSGVKGGYISDPLSAIFTT 
               
               
                   
               
               
                 465 
                 PRT 
                 Artificial 
                 Luk583 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 QIFYREESKYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVPIHGVKGGEISDPLSAIFTT 
               
               
                   
               
               
                 466 
                 PRT 
                 Artificial 
                 Luk584 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 QIFYQEVVEWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKGGWISDPLSAIFTT 
               
               
                   
               
               
                 467 
                 PRT 
                 Artificial 
                 Luk585 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYPETWIAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVVIHGVKGGIISWPLSAIFTT 
               
               
                   
               
               
                 468 
                 PRT 
                 Artificial 
                 Luk587 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VIPYQEYLGWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYWVGIYGVKGGFISPPLSAIFTT 
               
               
                   
               
               
                 469 
                 PRT 
                 Artificial 
                 Luk588 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIFYYEHQVAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIHGVKGGWISSPLSAIFTT 
               
               
                   
               
               
                 470 
                 PRT 
                 Artificial 
                 Luk589 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIIYAEEQRNGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVIIHGVKGGFISPPLSAIFTT 
               
               
                   
               
               
                 471 
                 PRT 
                 Artificial 
                 Luk590 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 SIFYLEERLTGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 FN3 domain 
                 TEYLVVIHGVKGGVISDPLSAIFTT 
               
               
                   
               
               
                 472 
                 PRT 
                 Artificial 
                 Luk592 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYYEAVHQGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKGGNISVPLSAIFTT 
               
               
                   
               
               
                 473 
                 PRT 
                 Artificial 
                 Luk593 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIFYVELVWKGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKGGYISDPLSAIFTT 
               
               
                   
               
               
                 474 
                 PRT 
                 Artificial 
                 Luk594 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VIHYGEYENGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIHGVKGGFISDPLSAIFTT 
               
               
                   
               
               
                 475 
                 PRT 
                 Artificial 
                 Luk595 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIIYFETKAYGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 FN3 domain 
                 TEYWVIIHGVKGGYISVPLSAIFTT 
               
               
                   
               
               
                 476 
                 PRT 
                 Artificial 
                 Luk596 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VIFYDEEWSKGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYAVFIYGVKGGAISEPLSAIFTT 
               
               
                   
               
               
                 477 
                 PRT 
                 Artificial 
                 Luk597 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 YIHYLETDPGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVSIYGVKGGWISPPLSAIFTT 
               
               
                   
               
               
                 478 
                 PRT 
                 Artificial 
                 Luk598 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VIFYDEDRPQGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKGGYLSIPLSAIFTT 
               
               
                   
               
               
                 479 
                 PRT 
                 Artificial 
                 Luk599 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 YIFYREETPHGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYWVLILGVKGGGISEPLSAIFTT 
               
               
                   
               
               
                 480 
                 PRT 
                 Artificial 
                 Luk601 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYIEDNKVGEAIVLTVPGSVRSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKGGIISEPLSAIFTT 
               
               
                   
               
               
                 481 
                 PRT 
                 Artificial 
                 Luk602 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VIFYQELNRDGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVIIHGVKGGFISPPLSAIFTT 
               
               
                   
               
               
                 482 
                 PRT 
                 Artificial 
                 Luk603 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 HIFYLEFWYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYNVIIHGVKGGWISEPLSAIFTT 
               
               
                   
               
               
                 483 
                 PRT 
                 Artificial 
                 Luk604 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 QIFYGEWPQEGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVVILGVKGGQASPPLSAIFTT 
               
               
                   
               
               
                 484 
                 PRT 
                 Artificial 
                 Luk605 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS, LukD 
                 RIHYLEHAARGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 binding FN3 
                 GTEYFVAIYGVKGGYISFPLSAIFTT 
               
               
                   
                   
                   
                 domain 
                   
               
               
                   
               
               
                 485 
                 PRT 
                 Artificial 
                 Luk606 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIHYLESYPRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVAIYGVKGGYLSPPLSAIFTT 
               
               
                   
               
               
                 486 
                 PRT 
                 Artificial 
                 Luk607 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 QIFYHEWVPWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYFVVIHGVKGGTISFPLSAIFTT 
               
               
                   
               
               
                 487 
                 PRT 
                 Artificial 
                 Luk608 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 NIFYGEYENGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVFIIGVKGGPDSLPLSAIFTT 
               
               
                   
               
               
                 488 
                 PRT 
                 Artificial 
                 Luk609 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 DIRYWEGPGYGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYRVRIVGVKGGKRSEPLSAIFTT 
               
               
                   
               
               
                 489 
                 PRT 
                 Artificial 
                 Luk610 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 FIYYGEYDPVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVIIQGVKGGQASGPLSAIFTT 
               
               
                   
               
               
                 490 
                 PRT 
                 Artificial 
                 Luk611 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 HIAYAEFWRYGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYWVNIAGVKGGEWSKPLSAIFTT 
               
               
                   
               
               
                 491 
                 PRT 
                 Artificial 
                 Luk612 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYQEESKYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKGGAISQPLSAIFTT 
               
               
                   
               
               
                 492 
                 PRT 
                 Artificial 
                 Luk613 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 NIFYIETDKPGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 FN3 domain 
                 TEYFVAIHGVKGGFISEPLSAIFTT 
               
               
                   
               
               
                 493 
                 PRT 
                 Artificial 
                 Luk614 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 HlgA, LukS 
                 QIFYTEPVGHGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 binding FN3 
                 GTEYFVAIHGVKGGTISPPLSAIFTT 
               
               
                   
                   
                   
                 domain 
                   
               
               
                   
               
               
                 494 
                 PRT 
                 Artificial 
                 Luk615 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 HIFYIEHRLQGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVLIHGVKGGFISPPLSAIFTT 
               
               
                   
               
               
                 495 
                 PRT 
                 Artificial 
                 Luk616 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 HIFYHEGLKSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVVIHGVKGGTISNPLSAIFTT 
               
               
                   
               
               
                 496 
                 PRT 
                 Artificial 
                 Luk617 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VIFYHETRVTGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVVIHGVKGGYISEPLSAIFTT 
               
               
                   
               
               
                 497 
                 PRT 
                 Artificial 
                 Luk618 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 SIFYQEAVEGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVPIHGVKGGWISQPLSAIFTT 
               
               
                   
               
               
                 498 
                 PRT 
                 Artificial 
                 Luk619 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 QILYVEEFTRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYVVIIHGVKGGYISKPLSAIFTT 
               
               
                   
               
               
                 499 
                 PRT 
                 Artificial 
                 Luk620 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TYIEALGFGEAIVLTVPGSERSYDLTGLKPGT 
               
               
                   
                   
                   
                 FN3 domain 
                 EYFVAIYGVKGGYISEPLSAIFTT 
               
               
                   
               
               
                 500 
                 PRT 
                 Artificial 
                 Luk621 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VIFYLEHWNPGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVPIHGVKGGSISPPLSAIFTT 
               
               
                   
               
               
                 501 
                 PRT 
                 Artificial 
                 Luk622 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIFYVEWEVVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVVIHGVKGGVISNPLSAIFTT 
               
               
                   
               
               
                 502 
                 PRT 
                 Artificial 
                 Luk623 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 RIFYLEESKNGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYQVVIHGVKGGVISPPLSAIFTT 
               
               
                   
               
               
                 503 
                 PRT 
                 Artificial 
                 Luk624 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 AIFYNEDHKSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVVIHGVKGGYISKPLSAIFTT 
               
               
                   
               
               
                 504 
                 PRT 
                 Artificial 
                 Luk625 HlgC, 
                 LPAPKNLVVSRVPEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 LIDYQEWHEGEAIHLLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYAVIIVGVKGGKGSHPLSAIFTT 
               
               
                   
               
               
                 505 
                 PRT 
                 Artificial 
                 Luk626 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPYAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYYETTIPGEAIDLVVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYGVGIDGVKGGRYSHPLSAIFTT 
               
               
                   
               
               
                 506 
                 PRT 
                 Artificial 
                 Luk627 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIFYKEEAIPGEAIALIVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYFVPIHGVKGGYISTPLSAIFTT 
               
               
                   
               
               
                 507 
                 PRT 
                 Artificial 
                 Luk628 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIDYTELHNWGEAIHLFVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVLIVGVKGGTGSIPLSAIFTT 
               
               
                   
               
               
                 508 
                 PRT 
                 Artificial 
                 Luk629 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 YITYEEEWWTGEAIFLDVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYLVTIKGVKGGPWSQPLSAIFTT 
               
               
                   
               
               
                 509 
                 PRT 
                 Artificial 
                 Luk630 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIWYHEWGPVGEAILLYVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYPVAIHGVKGGGTSHPLSAIFTT 
               
               
                   
               
               
                 510 
                 PRT 
                 Artificial 
                 Luk631 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 RIFYEELRYKGEAIWLFVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYHVHIWGVKGGYFSRPLSAIFTT 
               
               
                   
               
               
                 511 
                 PRT 
                 Artificial 
                 Luk632 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFI 
               
               
                   
                   
                   
                 binding FN3 
                 IDYWEQWNTGEAIHLYVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYSVYIVGVKGGYASWPLSAIFTT 
               
               
                   
               
               
                 512 
                 PRT 
                 Artificial 
                 Luk633 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WIGYDENHLYGEAIDLVVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYTVSIAGVKGGLESFPLSAIFTT 
               
               
                   
               
               
                 513 
                 PRT 
                 Artificial 
                 Luk634 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPEAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 HISYWEFPLGGEAIGLWVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVIIAGVKGGEFSNPLSAIFTT 
               
               
                   
               
               
                 514 
                 PRT 
                 Artificial 
                 Luk635 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFI 
               
               
                   
                   
                   
                 LukS binding 
                 IEYHEWFAKGEAIGLVVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYSVIIVGVKGGAYSFPLSAIFTT 
               
               
                   
               
               
                 515 
                 PRT 
                 Artificial 
                 Luk636 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 LIDYWEGEFDGEAIHLFVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYDVFIVGVKGGHGSDPLSAIFTT 
               
               
                   
               
               
                 516 
                 PRT 
                 Artificial 
                 Luk637 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 QIPYYELDSVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVGIYGVKGGYISPPLSAIFTT 
               
               
                   
               
               
                 517 
                 PRT 
                 Artificial 
                 Luk638 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 YIGYGEYDPTGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVLISGVKGGYYSDPLSAIFTT 
               
               
                   
               
               
                 518 
                 PRT 
                 Artificial 
                 Luk639 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 VIYYLESVARGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVPIYGVKGGYISYPLSAIFTT 
               
               
                   
               
               
                 519 
                 PRT 
                 Artificial 
                 Luk640 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIPYWESYYSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYVVAIYGVKGGYISSPLSAIFTT 
               
               
                   
               
               
                 520 
                 PRT 
                 Artificial 
                 Luk641 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GIYYGEYHSGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVLIDGVKGGLYSGPLSAIFTT 
               
               
                   
               
               
                 521 
                 PRT 
                 Artificial 
                 Luk642 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 YIVYAEYYWYGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYYVYIAGVKGGYGSDPLSAIFTT 
               
               
                   
               
               
                 522 
                 PRT 
                 Artificial 
                 Luk643 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIPYYESNLGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYWVGIYGVKGGHISSPLSAIFTT 
               
               
                   
               
               
                 523 
                 PRT 
                 Artificial 
                 Luk644 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TILYYELIDSGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 FN3 domain 
                 TEYFVGIYGVKGGYISLPLSAIFTT 
               
               
                   
               
               
                 524 
                 PRT 
                 Artificial 
                 Luk645 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 WISYGEYWPSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYFVLIRGVKGGDYSNPLSAIFTT 
               
               
                   
               
               
                 525 
                 PRT 
                 Artificial 
                 Luk646 LukD 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 RIFYGEYDGGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYGVYIYGVKGGYISQPLSAIFTT 
               
               
                   
               
               
                 526 
                 PRT 
                 Artificial 
                 Luk647 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 SIYYGEWDPTGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVLIVGVKGGSTSAPLSAIFTT 
               
               
                   
               
               
                 527 
                 PRT 
                 Artificial 
                 Luk648 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WIGYEEYYLVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYLVWIKGVKGGYVGRPLSAIFTT 
               
               
                   
               
               
                 528 
                 PRT 
                 Artificial 
                 Luk649 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GIAYSERVRYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVGISGVKGGPYSEPLSAIFTT 
               
               
                   
               
               
                 529 
                 PRT 
                 Artificial 
                 Luk650 HlgC, 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 LukS binding 
                 TIHYYESYTVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 FN3 domain 
                 GTEYWVGIYGVKGGYISEPLSAIFTT 
               
               
                   
               
               
                 530 
                 PRT 
                 Artificial 
                 Luk651 HlgA, 
                 LPAPKNLVLSRVTEDSARLSWAQATYYQFDS 
               
               
                   
                   
                   
                 LukD, LukAB 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 binding FN3 
                 PGTEYTVSIYGVLEVIPKLRYKVYSNPLSAIFTT 
               
               
                   
                   
                   
                 domain 
                   
               
               
                   
               
               
                 531 
                 PRT 
                 Artificial 
                 Luk652 HlgA 
                 LPAPKNLVVSRVTEDSARLSWSEVEDIPFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVLHYNRGQHPWHSNPLSAIFTT 
               
               
                   
               
               
                 532 
                 PRT 
                 Artificial 
                 Luk653 HlgA 
                 LPAPKNLVVSRVTEDSARLSWNLEVAFYFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVEHLDEVWWTANLSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 533 
                 PRT 
                 Artificial 
                 Luk654 HlgA, 
                 LPAPKNLVVSRVTEDSARLSWSHFPNDWFDS 
               
               
                   
                   
                   
                 LukD binding 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 FN3 domain 
                 PGTEYTVSIYGVHYWQFDIQSNPLSAIFTT 
               
               
                   
               
               
                 534 
                 PRT 
                 Artificial 
                 Luk655 HlgA 
                 LPAPKNLVVCRVTEDSARLSWRTYTSDAGFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVHEHAHIQYWHWSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 535 
                 PRT 
                 Artificial 
                 Luk656 HlgA 
                 LPAPKNLVVSRVTEDSARLSWKREQWANYF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVWEHLYKELWSYTSNPLS 
               
               
                   
                   
                   
                   
                 AIFTT 
               
               
                   
               
               
                 536 
                 PRT 
                 Artificial 
                 Luk657 LukF 
                 LPAPKNLVVSRVTEDSARLSWSELEARTHFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVSEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVAQQLVAWRGSNPLSAIFTT 
               
               
                   
               
               
                 537 
                 PRT 
                 Artificial 
                 Luk658 LukD 
                 LPAPKNLVVSRVTEDSARLSWKRARLDLPFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVDAWIPTVGSNPLSAIFTT 
               
               
                   
               
               
                 538 
                 PRT 
                 Artificial 
                 Luk659 HlgA 
                 LPAPKNLVVSRVTEDSARLSWINYWVLNYFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVEVWPQDHEWIDSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 539 
                 PRT 
                 Artificial 
                 Luk660 HlgA 
                 LPAPKNLVVSRVTEDSARLSWYREVDFTTFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVSSYYILHSNPLSAIFTT 
               
               
                   
               
               
                 540 
                 PRT 
                 Artificial 
                 Luk661 LukAB 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LITYREQIFAGEVIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYPVCIYGVKGGPISDPLSAIFTT 
               
               
                   
               
               
                 541 
                 PRT 
                 Artificial 
                 Luk662 LukS 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 VINYREVINEGEAIILHVPGSERSYRPERSETG 
               
               
                   
                   
                   
                 domain 
                 YRIHRHHSWC 
               
               
                   
               
               
                 542 
                 PRT 
                 Artificial 
                 Luk663 LukD 
                 LPAPKNLVVSRVTEDSARLSWVVHNHLAFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVEPYVYAQYESNPLSAIFTT 
               
               
                   
               
               
                 543 
                 PRT 
                 Artificial 
                 Luk664 HlgC 
                 LPAPKNLVVSRVTEDSARLSWKRKSGAPFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVHGWDPGSDSNPLSAIFTT 
               
               
                   
               
               
                 544 
                 PRT 
                 Artificial 
                 Luk665 HlgC 
                 LPAPKNLVVSRVTEDSARLSWWHVRGHDFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVVWLPTTDSNPLSAIFTT 
               
               
                   
               
               
                 545 
                 PRT 
                 Artificial 
                 Luk666 HlgC 
                 LPAPKNLVVSRVTEDSARLSWSPDRARFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVWSWDNDDASNPLSAIFTT 
               
               
                   
               
               
                 546 
                 PRT 
                 Artificial 
                 Luk667 HlgC 
                 LPAPKNLVVSRVTEDSARLSWFAGLQLFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVDWTVEEQSYHLWSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 547 
                 PRT 
                 Artificial 
                 Luk668 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTIPHYTFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVPGKYIEPRWHFSNPLSAIFTT 
               
               
                   
               
               
                 548 
                 PRT 
                 Artificial 
                 Luk669 HlgC 
                 LPAPKNLVVSRVTEDSARLSWKRYSWLFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVLTWDPNDPSNPLSAIFTT 
               
               
                   
               
               
                 549 
                 PRT 
                 Artificial 
                 Luk670 HlgC 
                 LPAPKNLVVSRVTEDSARLSWKTIVTTIFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVDHRGFPFWQYWSSNPLSAIFTT 
               
               
                   
               
               
                 550 
                 PRT 
                 Artificial 
                 Luk671 LukS 
                 LPAPKNLVVSRVTEDSARLSWYARRIYFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVETPNPYYDSNPLSAIFTT 
               
               
                   
               
               
                 551 
                 PRT 
                 Artificial 
                 Luk672 HlgC 
                 LPAPKNLVVSRVTEDSARLSWNLEQSTFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVTTYRITVPVRDHSNPLSAIFTT 
               
               
                   
               
               
                 552 
                 PRT 
                 Artificial 
                 Luk673 LukS 
                 LPAPKNLVVSRVTEDSARLSWRAAGTGFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVNWQPDYWTWPSNPLSAIFTT 
               
               
                   
               
               
                 553 
                 PRT 
                 Artificial 
                 Luk674 HlgC 
                 LPAPKNLVVSRVTEDSARLSWPISHLSFDSFLI 
               
               
                   
                   
                   
                 binding FN3 
                 QYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVWHQTVGRWFSNPLSAIFTT 
               
               
                   
               
               
                 554 
                 PRT 
                 Artificial 
                 Luk675 HlgC 
                 LPAPKNLVVSRVTEDSARLSWVRKKVNRFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVRNWKPNDPSNPLSAIFTT 
               
               
                   
               
               
                 555 
                 PRT 
                 Artificial 
                 Luk676 HlgC 
                 LPAPKNLVVSRVTEDSARLSWVSATQHPFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVDNWDPTDPSNPLSAIFTT 
               
               
                   
               
               
                 556 
                 PRT 
                 Artificial 
                 Luk677 HlgC 
                 LPAPKNLVVSRVTEDSARLSWPIALRDFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVISWDPTDPSNPLSAIFTT 
               
               
                   
               
               
                 557 
                 PRT 
                 Artificial 
                 Luk678 HlgC 
                 LPAPKNLVVSRVTEDSARLSWWDAEWFAPH 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                 domain 
                 GLKPGTEYTVSIYGVGLLKWPNYAVLSNPLS 
               
               
                   
                   
                   
                   
                 AIFTT 
               
               
                   
               
               
                 558 
                 PRT 
                 Artificial 
                 Luk679 HlgC 
                 LPAPKNLVVSRVTEDSARLSWPNNQRYYQPF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVLSWNPHHWSNPLSAIFTT 
               
               
                   
               
               
                 559 
                 PRT 
                 Artificial 
                 Luk680 HlgC 
                 LPAPKNLVVSRVTEDSARLSWYDARVTDEFF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVDDLLTNHLLAISNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 560 
                 PRT 
                 Artificial 
                 Luk681 HlgC 
                 LPAPKNLVVSRVTEDSARLSWKKRNTLKIFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVETWDPNDWSNPLSAIFTT 
               
               
                   
               
               
                 561 
                 PRT 
                 Artificial 
                 Luk682 HlgC 
                 LPAPKNLVVSRVTEDSARLSWLNRVKPNDFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVITWHPGHWSNPLSAIFTT 
               
               
                   
               
               
                 562 
                 PRT 
                 Artificial 
                 Luk683 LukD 
                 LPAPKNLVVSRVTEDSARLSWLTVRFTKFEF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLIVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVRSSKPRASNPLSAIFTT 
               
               
                   
               
               
                 563 
                 PRT 
                 Artificial 
                 Luk684 HlgC 
                 LPAPKNLVVSRVTEDSARLSWPNYRKVVSVF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVHTWHPGHYSNPLSAIFTT 
               
               
                   
               
               
                 564 
                 PRT 
                 Artificial 
                 Luk685 HlgC 
                 LPAPKNLVVSRVTEDSARLSWGNRQQVRSAF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVVGWHPNHPSNPLSAIFTT 
               
               
                   
               
               
                 565 
                 PRT 
                 Artificial 
                 Luk686 HlgC 
                 LPARKTWLFLVLPKTLRVCLGPRRTRRSTLF 
               
               
                   
                   
                   
                 binding FN3 
                 GLRTQRLLSGGKRLACWCRVLNVLTT 
               
               
                   
                   
                   
                 domain 
                   
               
               
                   
               
               
                 566 
                 PRT 
                 Artificial 
                 Luk687 HlgC, 
                 LPARKTWLFLVLPKTLRVCLGPRRTRRSTLS 
               
               
                   
                   
                   
                 LukS binding 
                 GLHTQRRHPGVKRSA 
               
               
                   
                   
                   
                 FN3 domain 
                   
               
               
                   
               
               
                 567 
                 PRT 
                 Artificial 
                 Luk688 HlgC 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GIEGGEYYYVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYGVPIGGVKGGPNSHPLSAIFTT 
               
               
                   
               
               
                 568 
                 PRT 
                 Artificial 
                 Luk689 LukD, 
                 LPAPKNLVVSRVTEDSARLSWWFYLTSWFAF 
               
               
                   
                   
                   
                 LukAB binding 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 FN3 domain 
                 LKPGTEYTVSIYGVLKVDPHVRSNPLSAIFTT 
               
               
                   
               
               
                 569 
                 PRT 
                 Artificial 
                 Luk690 HlgB 
                 LPAPKNLVVSRVTEDSARLSWYHVNFGFFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVYEDYPVIIFNNRSNPLSAIFTT 
               
               
                   
               
               
                 570 
                 PRT 
                 Artificial 
                 Luk691 LukF 
                 LPAPKNLVVSRVTEDSARLSWEDIKNKRFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVRGLANPFRVSNPLSAIFTT 
               
               
                   
               
               
                 571 
                 PRT 
                 Artificial 
                 Luk692 HlgB, 
                 LPAPKNLVVSRVTEDSARLSWWRYGPWFHF 
               
               
                   
                   
                   
                 LukD binding 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 FN3 domain 
                 LKPGTEYTVSIYGVRTHVRPPQWVSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 572 
                 PRT 
                 Artificial 
                 Luk693 HlgB, 
                 LPAPKAAVVSRVTEDSARLSWWRYGPWFHF 
               
               
                   
                   
                   
                 LukD binding 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 FN3 domain 
                 LKPGTEYTVSIYGVRTHVRPPQWVSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 573 
                 PRT 
                 Artificial 
                 Luk694 HlgB 
                 LPAPKNLVVSRVTEDSARLSWTNYYLESRHF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVRGQFGWYIEASNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 574 
                 PRT 
                 Artificial 
                 Luk695 LukD, 
                 LPAPKNLVVSRVTEDSARLSWLNWEQYITFD 
               
               
                   
                   
                   
                 LukAB binding 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 FN3 domain 
                 KPGTEYTVSIYGVWIIRDRSHWLNPSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 575 
                 PRT 
                 Artificial 
                 Luk696 HlgB 
                 LPAPKNLWLFLVLPKTLPVCLGGVMARGSTS 
               
               
                   
                   
                   
                 binding FN3 
                 TLS 
               
               
                   
                   
                   
                 domain 
                   
               
               
                   
               
               
                 576 
                 PRT 
                 Artificial 
                 Luk697 HlgB 
                 LPAPKNLVVSRVTEDSARLSWERFGPWFHFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVKTQPEQEFKSNPLSAIFTT 
               
               
                   
               
               
                 577 
                 PRT 
                 Artificial 
                 Luk698 HlgB 
                 LPAPKNLVVSRVTEDSARLSWWRYGPWFHF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVRTHVRPPQWISYPLSAIFTT 
               
               
                   
               
               
                 578 
                 PRT 
                 Artificial 
                 Luk699 HlgB 
                 LPAPKNLVVSRVTEDSARLSWWRYGPWFHF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVKQHHSLFHSNPLSAIFTT 
               
               
                   
               
               
                 579 
                 PRT 
                 Artificial 
                 Luk700 LukD 
                 LPAPKNLVVSRVTEDSARLSWNQQLNYQYF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVWYRWWSGSNPLSAIFTT 
               
               
                   
               
               
                 580 
                 PRT 
                 Artificial 
                 Luk701 HlgB 
                 LPAPKNLVVSRVTEDSARLSWWRYGPWFHF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVRTHNNQPGHYTSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 581 
                 PRT 
                 Artificial 
                 Luk702 HlgB 
                 LPAPKNLVVSRVTEDSARLSWWRYGPWFHF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVRTHVRPPQWVSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 582 
                 PRT 
                 Artificial 
                 Luk703 HlgB, 
                 LPAPKALVVSRVTEDSARLSWWRYGPWFHF 
               
               
                   
                   
                   
                 LukD binding 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 FN3 domain 
                 LKPGTEYTVSIYGVRTHVRPPQWVSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 583 
                 PRT 
                 Artificial 
                 Luk704 LukD 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 PILYQERWWKGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYGVPITGVKGGGVSFPLSAIFTT 
               
               
                   
               
               
                 584 
                 PRT 
                 Artificial 
                 Luk705 LukAB 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 HIWYRESWYFGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYYVVIRGVKGGSLSWPLSAIFTT 
               
               
                   
               
               
                 585 
                 PRT 
                 Artificial 
                 Luk706 HlgB 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 PISYYEQPRRGEAIWLFVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVYITGVKGGTWSFPLTATFTT 
               
               
                   
               
               
                 586 
                 PRT 
                 Artificial 
                 Luk707 LukE 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GIEYYETKTKGEAINLFVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYYVIILGVKGGEPSSPLVAPFTT 
               
               
                   
               
               
                 587 
                 PRT 
                 Artificial 
                 Luk708 LukAB 
                 LPAPKNLVVSRVTEDSARLSWKDVGEWKFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVHQLTITYSPTSNPLSAIFTT 
               
               
                   
               
               
                 588 
                 PRT 
                 Artificial 
                 Luk709 LukAB 
                 LPAPKNLVVSRVTEDSARLSWKRSYHPNFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVIDVPTVYHPGRSNPLSAIFTT 
               
               
                   
               
               
                 589 
                 PRT 
                 Artificial 
                 Luk710 LukAB 
                 LPAPKNLVVSRVTEDSARLSWLKKVSKFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVGEFPDRIYWGASNPLSAIFTT 
               
               
                   
               
               
                 590 
                 PRT 
                 Artificial 
                 Luk711 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYYWVQTIFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVGNLPDIFYKLPSNPLSAIFTT 
               
               
                   
               
               
                 591 
                 PRT 
                 Artificial 
                 Luk712 LukAB 
                 LPAPKNLVVSRVTEDSARLSWSKKLENFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVYHTHLIFSNPLSAIFTT 
               
               
                   
               
               
                 592 
                 PRT 
                 Artificial 
                 Luk713 LukAB 
                 LPAPKNLVVSRVTEDSARLSWHDLTIWPFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVVIEFEAWSNPLSAIFTT 
               
               
                   
               
               
                 593 
                 PRT 
                 Artificial 
                 Luk714 LukAB 
                 LPAPKNLVVSRVTEDSARLSWFPWTEWSAFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVENWLVLATATWSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 594 
                 PRT 
                 Artificial 
                 Luk715 LukAB 
                 LPAPKNLVVSRVTEDSARLSWVEWWIRPIEF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVWQQLYVEILISNPLSAIFTT 
               
               
                   
               
               
                 595 
                 PRT 
                 Artificial 
                 Luk716 LukAB 
                 LPAPKNLVVSRVTEDSARLSWSSQRTLPREF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVHVIIHSGSSNPLSAIFTT 
               
               
                   
               
               
                 596 
                 PRT 
                 Artificial 
                 Luk717 LukAB 
                 LPAPKNLVVSRVTEDSARLSWTSRLEDFWFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVGSEVYFRYYEHWSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 597 
                 PRT 
                 Artificial 
                 Luk718 LukAB 
                 LPAPKNLVVSRVTEDSARLSWQVNRNAQFH 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                 domain 
                 GLKPGTEYTVSIYGVAHPKLVWFAPPSNPLS 
               
               
                   
                   
                   
                   
                 AIFTT 
               
               
                   
               
               
                 598 
                 PRT 
                 Artificial 
                 Luk719 LukAB 
                 LPAPKNLVVSRVTEDSARLSWTFLEKWFIFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVVKHHDHDPEYPSNPLSAIFTT 
               
               
                   
               
               
                 599 
                 PRT 
                 Artificial 
                 Luk720 LukAB 
                 LPAPKNLVVSRVTEDSARLSWRHPRIQGGHF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVIHPFWWSPSNPLSAIFTT 
               
               
                   
               
               
                 600 
                 PRT 
                 Artificial 
                 Luk721 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYNAKKITPFF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVYPEVQHTTSNPLSAIFTT 
               
               
                   
               
               
                 601 
                 PRT 
                 Artificial 
                 Luk722 LukAB 
                 LPAPKNLVVSRVTEDSARLSWTEPWQEFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVILPTLHKSNPLSAIFTT 
               
               
                   
               
               
                 602 
                 PRT 
                 Artificial 
                 Luk723 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYRFPRIHFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVHTNIDLHNYNYLSNPLSAIFTT 
               
               
                   
               
               
                 603 
                 PRT 
                 Artificial 
                 Luk724 LukAB 
                 LPAPKNLVVSRVTEDSARLSWAERHPWFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVLRQNINIQDTNYSNPLSAIFTT 
               
               
                   
               
               
                 604 
                 PRT 
                 Artificial 
                 Luk725 LukAB 
                 LPAPKNLVVSRVTEDSARLSWPWWEGWTFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVKIRTLKASRSNPLSAIFTT 
               
               
                   
               
               
                 605 
                 PRT 
                 Artificial 
                 Luk726 LukAB 
                 LPAPKNLVVSRVTEDSARLSWAANFIDFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVYSPKLRWDLLNYSNPLSAIFTT 
               
               
                   
               
               
                 606 
                 PRT 
                 Artificial 
                 Luk727 LukAB 
                 LPAPKNLVVSRVTEDSARLSWFKQEFEFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVYYPEYYPREPWPSNPLSAIFTT 
               
               
                   
               
               
                 607 
                 PRT 
                 Artificial 
                 Luk728 LukAB 
                 LPAPKNLVVSRVTEDSARLSWEDEGTQFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVHWYWYWQRSNPLSAIFTT 
               
               
                   
               
               
                 608 
                 PRT 
                 Artificial 
                 Luk729 LukAB 
                 LPAPKNLVVSRVTEDSARLSWFGNQTGARSF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVYYQFRRTVRNSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 609 
                 PRT 
                 Artificial 
                 Luk730 LukAB 
                 LPAPKNLVVSRVTEDSARLSWGENRFVLSFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVLYHARHTWWLQQSNPLS 
               
               
                   
                   
                   
                   
                 AIFTT 
               
               
                   
               
               
                 610 
                 PRT 
                 Artificial 
                 Luk731 LukAB 
                 LPAPKNLVVSRVTEDSARLSWEKQQLKKWS 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                 domain 
                 GLKPGTGYTVSIYGVEHSNTRKRHSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 611 
                 PRT 
                 Artificial 
                 Luk732 LukAB 
                 LPAPKNLVVSRVTEDSARLSWKINDNSGYFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVAHRYENNPTLWSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 612 
                 PRT 
                 Artificial 
                 Luk733 LukAB 
                 LPAPKNLVVSRVTEDSARLSWPAFRWQPPGF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVGGFLYPWNYPTSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 613 
                 PRT 
                 Artificial 
                 Luk734 LukAB 
                 LPAPKNLVVSRVTEDSARLSWISEKPTTSLFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVWPRAIHYAYWFNSNPLSA 
               
               
                   
                   
                   
                   
                 IFTT 
               
               
                   
               
               
                 614 
                 PRT 
                 Artificial 
                 Luk735 LukAB 
                 LPAPKNLVVSRVTEDSARLSWQKSFQLTPFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVVVEYKWAATNPSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 615 
                 PRT 
                 Artificial 
                 Luk736 LukAB 
                 LPAPKNLVVSRVTEDSARLSWNASLNANHFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVVTSESNYGSNPLSAIFTT 
               
               
                   
               
               
                 616 
                 PRT 
                 Artificial 
                 Luk737 LukAB 
                 LPAPKNLVVSRVTEDSARLSWTNTARLNKFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVAITHSHHHHSSNPLSAIFTT 
               
               
                   
               
               
                 617 
                 PRT 
                 Artificial 
                 Luk738 LukAB 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 HILYWEPTPIGEAILLNVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYNVEIDGVKGGNPSDPLSAIFTT 
               
               
                   
               
               
                 618 
                 PRT 
                 Artificial 
                 Luk739 LukAB 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 SISYREGGQHGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYSVYILGVKGGDESEPLSAIFTT 
               
               
                   
               
               
                 619 
                 PRT 
                 Artificial 
                 Luk740 LukAB 
                 LPAPKNLVVSRVTEDSARLSWPWWNKHFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVIQWKKKPFSNPLSAIFTT 
               
               
                   
               
               
                 620 
                 PRT 
                 Artificial 
                 Luk741 LukAB 
                 LPAPKNLVVSRVTEDSARLSWPWWNKHFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVGEHDWYLLNYAESNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 621 
                 PRT 
                 Artificial 
                 Luk742 LukAB 
                 LPAPKNLVVSRVTEDSARLSWWAFSYLQFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVVEVRENSWNHSSNPLSAIFTT 
               
               
                   
               
               
                 622 
                 PRT 
                 Artificial 
                 Luk743 LukAB 
                 LPAPKNLVVSRVTEDSARLSWRETHNPQFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVIQWKKKPFSNPLSAIFTT 
               
               
                   
               
               
                 623 
                 PRT 
                 Artificial 
                 Luk744 LukAB 
                 LPAPKNLVVSRVTEDSARLSWTTRVDEFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVKWYNWKKNVNTESNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 624 
                 PRT 
                 Artificial 
                 Luk745 LukAB 
                 LPAPKNLVVSRVTEDSARLSWSQKDINFFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVLWYNWKKNWDNSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 625 
                 PRT 
                 Artificial 
                 Luk746 LukAB 
                 LPAPKNLVVSRVTEDSARLSWFTTNNHWFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVIQWKKKPFSNPLSAIFTT 
               
               
                   
               
               
                 626 
                 PRT 
                 Artificial 
                 Luk747 LukAB 
                 LPAPKNLVVSRVTEDSARLSWGRAREPASFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVLTVLFIDSSNPLSAIFTT 
               
               
                   
               
               
                 627 
                 PRT 
                 Artificial 
                 Luk748 LukAB 
                 LPAPKNLVVSRVTEDSVRLSWYNWKKKRLK 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                 domain 
                 GLKPGTEYTVSIYGVPNLWDIWNWVLSNPLS 
               
               
                   
                   
                   
                   
                 AIFTT 
               
               
                   
               
               
                 628 
                 PRT 
                 Artificial 
                 Luk749 LukAB 
                 LPAPKNLVVSRVTEDSARLSWGTFNLEVYIF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVVSANWHGHSNPLSAIFTT 
               
               
                   
               
               
                 629 
                 PRT 
                 Artificial 
                 Luk750 LukAB 
                 LPAPKNLVVSRVTEDSARLSWPQIFNELWEF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVWWYNRKKKRQSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 630 
                 PRT 
                 Artificial 
                 Luk751 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYNEQKKPINF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVWWYNRKKKRQSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 631 
                 PRT 
                 Artificial 
                 Luk752 LukAB 
                 LPAPKNLVVSRVTEDSARLSWRGKYSVVDF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVPWYNWKKKYVISNPLSA 
               
               
                   
                   
                   
                   
                 IFTT 
               
               
                   
               
               
                 632 
                 PRT 
                 Artificial 
                 Luk753 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYNTKKNPVFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVWLIKSLNAWFSNPLSAIFTT 
               
               
                   
               
               
                 633 
                 PRT 
                 Artificial 
                 Luk754 LukAB 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 VIIYEEVQWRGEAIRLFVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYDVNIRGVKGGGSSAPLSAIFTT 
               
               
                   
               
               
                 634 
                 PRT 
                 Artificial 
                 Luk755 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYNWKKKPGY 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                 domain 
                 GLKPGTEYTVSIYGVVHYHEWLASNPLSAIFTT 
               
               
                   
               
               
                 635 
                 PRT 
                 Artificial 
                 Luk756 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYTVKKKPQKF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVLDAYPIAEWPAQSNPLSA 
               
               
                   
                   
                   
                   
                 IFTT 
               
               
                   
               
               
                 636 
                 PRT 
                 Artificial 
                 Luk757 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYNTKKKPQFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVNEFILRWEGSNPLSAIFTT 
               
               
                   
               
               
                 637 
                 PRT 
                 Artificial 
                 Luk758 LukAB 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 YIGYYELIGAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYGVGIQGVKGGSYSAPLSAIFTT 
               
               
                   
               
               
                 638 
                 PRT 
                 Artificial 
                 Luk759 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYDRKVEFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVGVDGWGYLLLVSNPLSAIFTT 
               
               
                   
               
               
                 639 
                 PRT 
                 Artificial 
                 Luk760 LukAB 
                 LPAPKNLVVSRVTEDSARLSWIVPRTFHFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVWSQYITHWLPKSNPLSAIFTT 
               
               
                   
               
               
                 640 
                 PRT 
                 Artificial 
                 Luk761 LukAB 
                 LPAPKNLVVSRVTEDSARLSWNYRVATFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVSVELLSSNPLSAIFTT 
               
               
                   
               
               
                 641 
                 PRT 
                 Artificial 
                 Luk762 LukAB 
                 LPAPKNLVVSRVTEDSARLSWQPHRYEFYQF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVADFEFELHSNPLSAIFTT 
               
               
                   
               
               
                 642 
                 PRT 
                 Artificial 
                 Luk763 LukAB 
                 LPAPKNLVVSRVTEDSARLSWIPSYHLFAFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVNDAEQRYHHSNPLSAIFTT 
               
               
                   
               
               
                 643 
                 PRT 
                 Artificial 
                 Luk764 LukAB 
                 LPAPKNLVVSRVTEDSARLSWPINKTTSPFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVVEAHYDAFISNPLSAIFTT 
               
               
                   
               
               
                 644 
                 PRT 
                 Artificial 
                 Luk765 LukAB 
                 LPAPKNLVVSRVTEDSARLSWRKKLWEAEF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVILPDSFHVHHCNPLSAIFTT 
               
               
                   
               
               
                 645 
                 PRT 
                 Artificial 
                 Luk766 LukAB 
                 LPAPKNLVVSRVTEDSARLSWKRPQWRRLF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVGVNWPASVSSNPLSAIFTT 
               
               
                   
               
               
                 646 
                 PRT 
                 Artificial 
                 Luk767 LukAB 
                 LPAPKNLVVSRVTEDSARLSWIWDAIGPHFF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVSWFIRITASNPLSAIFTT 
               
               
                   
               
               
                 647 
                 PRT 
                 Artificial 
                 Luk768 LukAB 
                 LPAPKNLVVSRVTEDSARLSWRGLEPRWGFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVPWYEHLRILNATSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 648 
                 PRT 
                 Artificial 
                 Luk769 LukAB 
                 LPAPKNLVVSRVTEDSARLSWDWWSNPIKFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVINWHWYQTHRTSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 649 
                 PRT 
                 Artificial 
                 Luk770 LukAB 
                 LPAPKNLVVSRVTEDSARLSWEQWHAGVNP 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                 domain 
                 GLKPGTEYTVSIYGVSYYVRVLQFALFSNPLS 
               
               
                   
                   
                   
                   
                 AIFTT 
               
               
                   
               
               
                 650 
                 PRT 
                 Artificial 
                 Luk771 LukAB 
                 LPAPKNLVVSRVTEDSARLSWAQVETQIHFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGESDLLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVSHYRRHVPRHSNPLSAIFTT 
               
               
                   
               
               
                 651 
                 PRT 
                 Artificial 
                 Luk772 LukAB 
                 LPAPKNLVVSRVTEDSARLSWIAYYYGQTFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVWHENYAKWPDPSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 652 
                 PRT 
                 Artificial 
                 Luk773 LukAB 
                 LPAPKNLVVSRVTEDSARLSWWHWLTHHFF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVFFRWQDPLHDLISNPLSA 
               
               
                   
                   
                   
                   
                 IFTT 
               
               
                   
               
               
                 653 
                 PRT 
                 Artificial 
                 Luk774 LukAB 
                 LPAPKNLVVSRVTEDSARLSWKYKEHFQIFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVERIWWQYRSNPLSAIFTT 
               
               
                   
               
               
                 654 
                 PRT 
                 Artificial 
                 Luk775 LukAB 
                 LPAPKNLVVSRVTEDSARLSWVGDAYFNHLF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVEARPKPRLSNPLSAIFTT 
               
               
                   
               
               
                 655 
                 PRT 
                 Artificial 
                 Luk776 LukAB 
                 LPAPKNLVVSRVTEDSARLSWNKRVPNFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVIQWKKKPFSNPLSAIFTT 
               
               
                   
               
               
                 656 
                 PRT 
                 Artificial 
                 Luk777 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYNEQKKRSFF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVPIRRSGWDVRSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 657 
                 PRT 
                 Artificial 
                 Luk778 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYNTKKKPVFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVKVDDWPDYWQSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 658 
                 PRT 
                 Artificial 
                 Luk779 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYNVKKTFQFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVAAVWYTPNTQSNPLSAIFTT 
               
               
                   
               
               
                 659 
                 PRT 
                 Artificial 
                 Luk780 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYNSKKKVQF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVIESHWWQLKWPSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 660 
                 PRT 
                 Artificial 
                 Luk781 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYNTKKKTAFF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVDEVGYLHIETSNPLSAIFTT 
               
               
                   
               
               
                 661 
                 PRT 
                 Artificial 
                 Luk782 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYNEKKIFQFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGAKGPNFPSQNDPSSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 662 
                 PRT 
                 Artificial 
                 Luk783 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYNWKKKRLK 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                 domain 
                 GLKPGTEYTVSIYGVASPVYTGLYLGSNPLSA 
               
               
                   
                   
                   
                   
                 IFTT 
               
               
                   
               
               
                 663 
                 PRT 
                 Artificial 
                 Luk784 LukAB 
                 LPAPKNLVVSRVTEDSARLSWYTVKKKPQKF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVGDQLLEIGRTGSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 664 
                 PRT 
                 Artificial 
                 Luk785 LukAB 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 FIGYREVPFLGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYIVLIWGVKGGIPSQPLSAIFTT 
               
               
                   
               
               
                 665 
                 PRT 
                 Artificial 
                 Luk786 LukAB 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 FIPYREEAPLGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYDVIIVGVKGGYPSKPLSAIFTT 
               
               
                   
               
               
                 666 
                 PRT 
                 Artificial 
                 Luk787 LukAB 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WIVYHELVHSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYPVFIVGVKGGWYSPPLSAIFTT 
               
               
                   
               
               
                 667 
                 PRT 
                 Artificial 
                 TCL24 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 XIXYXEXXXXGEAIXLXVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYXVXIXGVKGGXXSXPLXAXFTT 
               
               
                   
               
               
                 668 
                 PRT 
                 
                   S. aureus 
                 
                 ClfA 
                 GSMASENSVTQSDSASNESKSNDSSSVSAAP 
               
               
                   
                   
                   
                   
                 KTDDTNVSDTKTSSNTNNGETSVAQNPAQQE 
               
               
                   
                   
                   
                   
                 TTQSSSTNATTEETPVTGEATTTTTNQANTPA 
               
               
                   
                   
                   
                   
                 TTQSSNTNAEELVNQTSNETTFNDTNTVSSV 
               
               
                   
                   
                   
                   
                 NSPQNSTNAENVSTTQDTSTEATPSNNESAPQ 
               
               
                   
                   
                   
                   
                 STDASNKDVVNQAVNTSAPRMRAFSLAAVA 
               
               
                   
                   
                   
                   
                 ADAPAAGTDITNQLTNVTVGIDSGTTVYPHQ 
               
               
                   
                   
                   
                   
                 AGYVKLNYGFSVPNSAVKGDTFKITVPKELN 
               
               
                   
                   
                   
                   
                 LNGVTSTAKVPPIMAGDQVLANGVIDSDGNV 
               
               
                   
                   
                   
                   
                 IYTFTDYVNTKDDVKATLTMPAYIDPENVKK 
               
               
                   
                   
                   
                   
                 TGNVTLATGIGSTTANKTVLVDYEKYGKFYN 
               
               
                   
                   
                   
                   
                 LSIKGTIDQIDKTNNTYRQTIYVNPSGDNVIAP 
               
               
                   
                   
                   
                   
                 VLTGNLKPNTDSNALIDQQNTSIKVYKVDNA 
               
               
                   
                   
                   
                   
                 ADLSESYFVNPENFEDVTNSVNITFPNPNQYK 
               
               
                   
                   
                   
                   
                 VEFNTPDDQITTPYIVVVNGHIDPNSKGDLAL 
               
               
                   
                   
                   
                   
                 RSTLYGYNSNIIWRSMSWDNEVAFNNGSGSG 
               
               
                   
                   
                   
                   
                 DGIDKPVVPEQPDEPGEIEPIPEDSDSDPGSDS 
               
               
                   
                   
                   
                   
                 GSDSNSDSGSDSGSDSTSDSGSDSASDSDSAS 
               
               
                   
                   
                   
                   
                 DSDSASDSDSASDSDSASDSDSDNDSDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSASDSDSDSDSDSDSDSDSDSDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSDSDSDSDSESDSDSESDSDSDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSDSDSDSASDSDSGSDSDSSSDSDSES 
               
               
                   
                   
                   
                   
                 DSNSDSESGSNNNVVPPNSPKNGTNASNKNE 
               
               
                   
                   
                   
                   
                 AKDSKEPLPDTLEHHHHHH 
               
               
                   
               
               
                 669 
                 PRT 
                 
                   S. aureus 
                 
                 ClfB 
                 GSMASEQSNDTTQSSKNNASADSEKNNMIET 
               
               
                   
                   
                   
                   
                 PQLNTTANDTSDISANTNSANVDSTTKPMST 
               
               
                   
                   
                   
                   
                 QTSNTTTTEPASTNETPQPTAIKNQATAAKM 
               
               
                   
                   
                   
                   
                 QDQTVPQEANSQVDNKTTNDANSIATNSELK 
               
               
                   
                   
                   
                   
                 NSQTLDLPQSSPQTISNAQGTSKPSVRTRAVR 
               
               
                   
                   
                   
                   
                 SLAVAEPVVNAADAKGTNVNDKVTASNFKL 
               
               
                   
                   
                   
                   
                 EKTTFDPNQSGNTFMAANFTVTDKVKSGDY 
               
               
                   
                   
                   
                   
                 FTAKLPDSLTGNGDVDYSNSNNTMPIADIKST 
               
               
                   
                   
                   
                   
                 NGDVVAKATYDILTKTYTFVFTDYVNNKENI 
               
               
                   
                   
                   
                   
                 NGQFSLPLFTDRAKAPKSGTYDANINIADEM 
               
               
                   
                   
                   
                   
                 FNNKITYNYSSPIAGIDKPNGANISSQIIGVDT 
               
               
                   
                   
                   
                   
                 ASGQNTYKQTVFVNPKQRVLGNTWVYIKGY 
               
               
                   
                   
                   
                   
                 QDKIEESSGKVSATDTKLRIFEVNDTSKLSDS 
               
               
                   
                   
                   
                   
                 YYADPNDSNLKEVTDQFKNRIYYEHPNVASI 
               
               
                   
                   
                   
                   
                 KFGDITKTYVVLVEGHYDNTGKNLKTQVIQE 
               
               
                   
                   
                   
                   
                 NVDPVTNRDYSIFGWNNENVVRYGGGSADG 
               
               
                   
                   
                   
                   
                 DSAVNPKDPTPGPPVDPEPSPDPEPEPTPDPEP 
               
               
                   
                   
                   
                   
                 SPDPEPEPSPDPDPDSDSDSDSGSDSDSGSDSD 
               
               
                   
                   
                   
                   
                 SESDSDSDSDSDSDSDSDSESDSDSESDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSDSDSDSDSDSDSDSDSDSDSDSESDS 
               
               
                   
                   
                   
                   
                 DSESDSESDSDSDSDSDSDSDSDSDSDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDS 
               
               
                   
                   
                   
                   
                 DSDSDSDSDSDSRVTPPNNEQKAPSNPKGEV 
               
               
                   
                   
                   
                   
                 NHSNKVSKQHKTDALPETLEHHHHHH 
               
               
                   
               
               
                 670 
                 PRT 
                 Artificial 
                 SD peptide 
                 BIOTIN- 
               
               
                   
                   
                   
                   
                 SDSDSDSDSDSDSDSDSDSDHHHHHHHH 
               
               
                   
               
               
                 671 
                 PRT 
                 
                   S. aureus 
                 
                 LukA wt 
                 NSAHHHHHHGSHKDSQDQNKKEHVDKSQQ 
               
               
                   
                   
                   
                   
                 KDKRNVTNKDKNSTAPDDIGKNGKITKRTET 
               
               
                   
                   
                   
                   
                 VYDEKTNILQNLQFDFIDDPTYDKNVLLVKK 
               
               
                   
                   
                   
                   
                 QGSIHSNLKFESHKEEKNSNWLKYPSEYHVD 
               
               
                   
                   
                   
                   
                 FQVKRNRKTEILDQLPKNKISTAKVDSTFSYS 
               
               
                   
                   
                   
                   
                 SGGKFDSTKGIGRTSSNSYSKTISYNQQNYDT 
               
               
                   
                   
                   
                   
                 IASGKNNNWHVHWSVIANDLKYGGEVKNR 
               
               
                   
                   
                   
                   
                 NDELLFYRNTRIATVENPELSFASKYRYPALV 
               
               
                   
                   
                   
                   
                 RSGFNPEFLTYLSNEKSNEKTQFEVTYTRNQ 
               
               
                   
                   
                   
                   
                 DILKNRPGIHYAPPILEKNKDGQRLIVTYEVD 
               
               
                   
                   
                   
                   
                 WKNKTVKVVDKYSDDNKPYKEG 
               
               
                   
               
               
                 672 
                 PRT 
                 Artificial 
                 Luk17W32A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 AITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 673 
                 PRT 
                 Artificial 
                 Luk17T34A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WIAYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 674 
                 PRT 
                 Artificial 
                 Luk17E36A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYAEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 675 
                 PRT 
                 Artificial 
                 Luk17K38A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEAFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 676 
                 PRT 
                 Artificial 
                 Luk17F39A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKAYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 677 
                 PRT 
                 Artificial 
                 Luk17Y40A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFARGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 678 
                 PRT 
                 Artificial 
                 Luk17R41A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 679 
                 PRT 
                 Artificial 
                 Luk17K68A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYAVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 680 
                 PRT 
                 Artificial 
                 Luk17W70A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVAIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 681 
                 PRT 
                 Artificial 
                 Luk17V72A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIAGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 682 
                 PRT 
                 Artificial 
                 Luk17Q78A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGAGSWPLSAIFTT 
               
               
                   
               
               
                 683 
                 PRT 
                 Artificial 
                 Luk17G79A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQASWPLSAIFTT 
               
               
                   
               
               
                 684 
                 PRT 
                 Artificial 
                 Luk17W81A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSAPLSAIFTT 
               
               
                   
               
               
                 685 
                 PRT 
                 Artificial 
                 Luk17G42A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRAEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 686 
                 PRT 
                 Artificial 
                 Luk17V46A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIALTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 687 
                 PRT 
                 Artificial 
                 Luk17E66A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTAYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 688 
                 PRT 
                 Artificial 
                 Luk17G77A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGAQGSWPLSAIFTT 
               
               
                   
               
               
                 689 
                 PRT 
                 Artificial 
                 Luk17P82A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWALSAIFTT 
               
               
                   
               
               
                 690 
                 PRT 
                 Artificial 
                 Luk17S84A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLAAIFTT 
               
               
                   
               
               
                 691 
                 PRT 
                 Artificial 
                 Luk17I86A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAAFTT 
               
               
                   
               
               
                 692 
                 PRT 
                 Artificial 
                 Luk17W32S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 SITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 693 
                 PRT 
                 Artificial 
                 Luk17T34S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WISYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 694 
                 PRT 
                 Artificial 
                 Luk17E36S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYSEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 695 
                 PRT 
                 Artificial 
                 Luk17K38S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEESFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 696 
                 PRT 
                 Artificial 
                 Luk17F39S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKSYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 697 
                 PRT 
                 Artificial 
                 Luk17Y40S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFSRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 698 
                 PRT 
                 Artificial 
                 Luk17R41S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 699 
                 PRT 
                 Artificial 
                 Luk17K68S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYSVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 700 
                 PRT 
                 Artificial 
                 Luk17W70S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVSIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 701 
                 PRT 
                 Artificial 
                 Luk17V72S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWISGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 702 
                 PRT 
                 Artificial 
                 Luk17Q78S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGSGSWPLSAIFTT 
               
               
                   
               
               
                 703 
                 PRT 
                 Artificial 
                 Luk17G79S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQSSWPLSAIFTT 
               
               
                   
               
               
                 704 
                 PRT 
                 Artificial 
                 Luk17W81S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSSPLSAIFTT 
               
               
                   
               
               
                 705 
                 PRT 
                 Artificial 
                 Luk17G42S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRSEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 706 
                 PRT 
                 Artificial 
                 Luk17A44S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGESIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 707 
                 PRT 
                 Artificial 
                 Luk17V46S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAISLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 708 
                 PRT 
                 Artificial 
                 Luk17E66S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTSYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 709 
                 PRT 
                 Artificial 
                 Luk17G77S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGSQGSWPLSAIFTT 
               
               
                   
               
               
                 710 
                 PRT 
                 Artificial 
                 Luk17P82S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWSLSAIFTT 
               
               
                   
               
               
                 711 
                 PRT 
                 Artificial 
                 Luk17S84S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 712 
                 PRT 
                 Artificial 
                 Luk17I86S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSASFTT 
               
               
                   
               
               
                 713 
                 PRT 
                 Artificial 
                 Luk17W32L 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 LITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 714 
                 PRT 
                 Artificial 
                 Luk17T34Q 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WIQYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 715 
                 PRT 
                 Artificial 
                 Luk17E36Q 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYQEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 716 
                 PRT 
                 Artificial 
                 Luk17F39E 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKEYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 717 
                 PRT 
                 Artificial 
                 Luk17Y40K 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFKRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 718 
                 PRT 
                 Artificial 
                 Luk17R41V 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 719 
                 PRT 
                 Artificial 
                 Luk17K68T 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYTVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 720 
                 PRT 
                 Artificial 
                 Luk17V72Y 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIYGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 721 
                 PRT 
                 Artificial 
                 Luk17Q78H 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGHGSWPLSAIFTT 
               
               
                   
               
               
                 722 
                 PRT 
                 Artificial 
                 Luk17G79R 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQRSWPLSAIFTT 
               
               
                   
               
               
                 723 
                 PRT 
                 Artificial 
                 Luk17W81N 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSNPLSAIFTT 
               
               
                   
               
               
                 724 
                 PRT 
                 Artificial 
                 Luk17wtFG 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGHRSNPLSAIFTT 
               
               
                   
               
               
                 725 
                 PRT 
                 Artificial 
                 Luk17S38FG 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVELIYHGWLDFVFSNPLSAIFTT 
               
               
                   
               
               
                 726 
                 PRT 
                 Artificial 
                 Luk17W32D 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 DITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 727 
                 PRT 
                 Artificial 
                 Luk17W32T 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 TITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 728 
                 PRT 
                 Artificial 
                 Luk17W32Q 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 QITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 729 
                 PRT 
                 Artificial 
                 Luk17W81D 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSDPLSAIFTT 
               
               
                   
               
               
                 730 
                 PRT 
                 Artificial 
                 Luk17W81L 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSLPLSAIFTT 
               
               
                   
               
               
                 731 
                 PRT 
                 Artificial 
                 Luk17W81T 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSTPLSAIFTT 
               
               
                   
               
               
                 732 
                 PRT 
                 Artificial 
                 Luk17W81Q 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 WITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSQPLSAIFTT 
               
               
                   
               
               
                 733 
                 PRT 
                 Artificial 
                 Luk17W32LW81S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 LITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSSPLSAIFTT 
               
               
                   
               
               
                 734 
                 PRT 
                 Artificial 
                 Luk17W32TW81S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 TITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSSPLSAIFTT 
               
               
                   
               
               
                 735 
                 PRT 
                 Artificial 
                 Luk17W32SW81S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 SITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSSPLSAIFTT 
               
               
                   
               
               
                 736 
                 PRT 
                 Artificial 
                 Luk17W32DW81D 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 DITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSDPLSAIFTT 
               
               
                   
               
               
                 737 
                 PRT 
                 Artificial 
                 Luk17W32TW81T 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 TITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSTPLSAIFTT 
               
               
                   
               
               
                 738 
                 PRT 
                 Artificial 
                 Luk17W32QW81Q 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 QITYEEKFYRGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYKVWIVGVKGGQGSQPLSAIFTT 
               
               
                   
               
               
                 739 
                 PRT 
                 Artificial 
                 Luk26H32A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 AIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 740 
                 PRT 
                 Artificial 
                 Luk26E34A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIAYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 741 
                 PRT 
                 Artificial 
                 Luk26A36S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYSEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 742 
                 PRT 
                 Artificial 
                 Luk26P38A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEAWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 743 
                 PRT 
                 Artificial 
                 Luk26W39A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPAVWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 744 
                 PRT 
                 Artificial 
                 Luk26V40A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWAWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 745 
                 PRT 
                 Artificial 
                 Luk26W41A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 746 
                 PRT 
                 Artificial 
                 Luk26V68A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYAVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 747 
                 PRT 
                 Artificial 
                 Luk26F70A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVAIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 748 
                 PRT 
                 Artificial 
                 Luk26G72A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIAGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 749 
                 PRT 
                 Artificial 
                 Luk26H78A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGANSTPLSAIFTT 
               
               
                   
               
               
                 750 
                 PRT 
                 Artificial 
                 Luk26N79A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHASTPLSAIFTT 
               
               
                   
               
               
                 751 
                 PRT 
                 Artificial 
                 Luk26T81A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSAPLSAIFTT 
               
               
                   
               
               
                 752 
                 PRT 
                 Artificial 
                 Luk26G42A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWAEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 753 
                 PRT 
                 Artificial 
                 Luk26V46A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIALTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 754 
                 PRT 
                 Artificial 
                 Luk26E66A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTAYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 755 
                 PRT 
                 Artificial 
                 Luk26G77A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGAHNSTPLSAIFTT 
               
               
                   
               
               
                 756 
                 PRT 
                 Artificial 
                 Luk26P82A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTALSAIFTT 
               
               
                   
               
               
                 757 
                 PRT 
                 Artificial 
                 Luk26S84A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLAAIFTT 
               
               
                   
               
               
                 758 
                 PRT 
                 Artificial 
                 Luk26I86A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAAFTT 
               
               
                   
               
               
                 759 
                 PRT 
                 Artificial 
                 Luk26H32S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 SIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 760 
                 PRT 
                 Artificial 
                 Luk26E34S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HISYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 761 
                 PRT 
                 Artificial 
                 Luk26A36S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYSEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 762 
                 PRT 
                 Artificial 
                 Luk26P38S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAESWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 763 
                 PRT 
                 Artificial 
                 Luk26W39S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPSVWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 764 
                 PRT 
                 Artificial 
                 Luk26V40S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWSWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 765 
                 PRT 
                 Artificial 
                 Luk26W41S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVSGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 766 
                 PRT 
                 Artificial 
                 Luk26V68S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 767 
                 PRT 
                 Artificial 
                 Luk26F70S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVSIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 768 
                 PRT 
                 Artificial 
                 Luk26G72S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFISGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 769 
                 PRT 
                 Artificial 
                 Luk26H78S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGSNSTPLSAIFTT 
               
               
                   
               
               
                 770 
                 PRT 
                 Artificial 
                 Luk26N79S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHSSTPLSAIFTT 
               
               
                   
               
               
                 771 
                 PRT 
                 Artificial 
                 Luk26T81S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSSPLSAIFTT 
               
               
                   
               
               
                 772 
                 PRT 
                 Artificial 
                 Luk26G42S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWSEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 773 
                 PRT 
                 Artificial 
                 Luk26A44S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGESIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 774 
                 PRT 
                 Artificial 
                 Luk26V46S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAISLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 775 
                 PRT 
                 Artificial 
                 Luk26E66S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTSYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 776 
                 PRT 
                 Artificial 
                 Luk26G77S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGSHNSTPLSAIFTT 
               
               
                   
               
               
                 777 
                 PRT 
                 Artificial 
                 Luk26P82S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTSLSAIFTT 
               
               
                   
               
               
                 778 
                 PRT 
                 Artificial 
                 Luk26S84S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 779 
                 PRT 
                 Artificial 
                 Luk26I86S 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSASFTT 
               
               
                   
               
               
                 780 
                 PRT 
                 Artificial 
                 Luk26H32L 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 LIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 781 
                 PRT 
                 Artificial 
                 Luk26E34Q 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIQYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 782 
                 PRT 
                 Artificial 
                 Luk26A36Q 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYQEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 783 
                 PRT 
                 Artificial 
                 Luk26W39E 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPEVWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 784 
                 PRT 
                 Artificial 
                 Luk26V40K 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWKWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 785 
                 PRT 
                 Artificial 
                 Luk26W41V 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 786 
                 PRT 
                 Artificial 
                 Luk26V68T 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYTVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 787 
                 PRT 
                 Artificial 
                 Luk26G72Y 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIYGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 788 
                 PRT 
                 Artificial 
                 Luk26N79R 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHRSTPLSAIFTT 
               
               
                   
               
               
                 789 
                 PRT 
                 Artificial 
                 Luk26T81N 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSNPLSAIFTT 
               
               
                   
               
               
                 790 
                 PRT 
                 Artificial 
                 Luk26wtFG 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHRSNPLSAIFTT 
               
               
                   
               
               
                 791 
                 PRT 
                 Artificial 
                 Luk26S38FG 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVELIYHGWLDFVFSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 792 
                 PRT 
                 Artificial 
                 Luk26V68D 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYDVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 793 
                 PRT 
                 Artificial 
                 Luk26V68T 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYTVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 794 
                 PRT 
                 Artificial 
                 Luk26V68Q 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYQVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 795 
                 PRT 
                 Artificial 
                 Luk26W39Q 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPQVWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 796 
                 PRT 
                 Artificial 
                 Luk26W39T 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPTVWGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 797 
                 PRT 
                 Artificial 
                 Luk26S84D 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLDAIFTT 
               
               
                   
               
               
                 798 
                 PRT 
                 Artificial 
                 Luk26S84T 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLTAIFTT 
               
               
                   
               
               
                 799 
                 PRT 
                 Artificial 
                 Luk26S84Q 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYVVFIGGVKGGHNSTPLQAIFTT 
               
               
                   
               
               
                 800 
                 PRT 
                 Artificial 
                 Luk26W41Q 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVQGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 801 
                 PRT 
                 Artificial 
                 Luk26W41T 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVTGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 802 
                 PRT 
                 Artificial 
                 Luk26V68DS84D 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYDVFIGGVKGGHNSTPLDAIFTT 
               
               
                   
               
               
                 803 
                 PRT 
                 Artificial 
                 Luk26V68DS84T 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYDVFIGGVKGGHNSTPLTAIFTT 
               
               
                   
               
               
                 804 
                 PRT 
                 Artificial 
                 Luk26V68TS84D 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYTVFIGGVKGGHNSTPLDAIFTT 
               
               
                   
               
               
                 805 
                 PRT 
                 Artificial 
                 Luk26V68TS84T 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYTVFIGGVKGGHNSTPLTAIFTT 
               
               
                   
               
               
                 806 
                 PRT 
                 Artificial 
                 Luk26V68QS84Q 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYQVFIGGVKGGHNSTPLQAIFTT 
               
               
                   
               
               
                 807 
                 PRT 
                 Artificial 
                 Luk26V68QS84D 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYQVFIGGVKGGHNSTPLDAIFTT 
               
               
                   
               
               
                 808 
                 PRT 
                 Artificial 
                 Luk26V68QS84T 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYQVFIGGVKGGHNSTPLTAIFTT 
               
               
                   
               
               
                 809 
                 PRT 
                 Artificial 
                 Luk26V68DS84Q 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYDVFIGGVKGGHNSTPLQAIFTT 
               
               
                   
               
               
                 810 
                 PRT 
                 Artificial 
                 Luk26V68TS84Q 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPWVWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYTVFIGGVKGGHNSTPLQAIFTT 
               
               
                   
               
               
                 811 
                 PRT 
                 Artificial 
                 Luk26W39QW41Q 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPQVQGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 812 
                 PRT 
                 Artificial 
                 Luk26W39QW41T 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPQVTGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 813 
                 PRT 
                 Artificial 
                 Luk26W39TW41Q 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPTVQGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 814 
                 PRT 
                 Artificial 
                 Luk26W39TW41T 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 HIEYAEPTVTGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 815 
                 PRT 
                 Artificial 
                 Luk27P32A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 AIVYQEWQFYGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYLVDIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 816 
                 PRT 
                 Artificial 
                 Luk27V34A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 PIAYQEWQFYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYLVDIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 817 
                 PRT 
                 Artificial 
                 Luk27Q36A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 PIVYAEWQFYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYLVDIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 818 
                 PRT 
                 Artificial 
                 Luk27W38A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 PIVYQEAQFYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYLVDIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 819 
                 PRT 
                 Artificial 
                 Luk27Q39A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 PIVYQEWAFYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYLVDIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 820 
                 PRT 
                 Artificial 
                 Luk27F40A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 PIVYQEWQAYGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYLVDIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 821 
                 PRT 
                 Artificial 
                 Luk27Y41A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 PIVYQEWQFAGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYLVDIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 822 
                 PRT 
                 Artificial 
                 Luk27L68A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 PIVYQEWQFYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYAVDIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 823 
                 PRT 
                 Artificial 
                 Luk27D70A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 PIVYQEWQFYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYLVAIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 824 
                 PRT 
                 Artificial 
                 Luk27Y72A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 PIVYQEWQFYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYLVDIAGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 825 
                 PRT 
                 Artificial 
                 Luk27S78A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 PIVYQEWQFYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYLVDIYGVKGGAWSYPLSAIFTT 
               
               
                   
               
               
                 826 
                 PRT 
                 Artificial 
                 Luk27W79A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 PIVYQEWQFYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYLVDIYGVKGGSASYPLSAIFTT 
               
               
                   
               
               
                 827 
                 PRT 
                 Artificial 
                 Luk27Y81A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 PIVYQEWQFYGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYLVDIYGVKGGSWSAPLSAIFTT 
               
               
                   
               
               
                 828 
                 PRT 
                 Artificial 
                 Luk38E75A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYTVSIYGVALIYHGWLDFVFSNPLSAIFTT 
               
               
                   
               
               
                 829 
                 PRT 
                 Artificial 
                 Luk38L76A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYTVSIYGVEAIYHGWLDFVFSNPLSAIFTT 
               
               
                   
               
               
                 830 
                 PRT 
                 Artificial 
                 Luk38I77A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYTVSIYGVELAYHGWLDFVFSNPLSAIFTT 
               
               
                   
               
               
                 831 
                 PRT 
                 Artificial 
                 Luk38Y78A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYTVSIYGVELIAHGWLDFVFSNPLSAIFTT 
               
               
                   
               
               
                 832 
                 PRT 
                 Artificial 
                 Luk38H79A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYTVSIYGVELIYAGWLDFVFSNPLSAIFTT 
               
               
                   
               
               
                 833 
                 PRT 
                 Artificial 
                 Luk38G80A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYTVSIYGVELIYHAWLDFVFSNPLSAIFTT 
               
               
                   
               
               
                 834 
                 PRT 
                 Artificial 
                 Luk38W81A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYTVSIYGVELIYHGALDFVFSNPLSAIFTT 
               
               
                   
               
               
                 835 
                 PRT 
                 Artificial 
                 Luk38L82A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYTVSIYGVELIYHGWADFVFSNPLSAIFTT 
               
               
                   
               
               
                 836 
                 PRT 
                 Artificial 
                 Luk38D83A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYTVSIYGVELIYHGWLAFVFSNPLSAIFTT 
               
               
                   
               
               
                 837 
                 PRT 
                 Artificial 
                 Luk38F84A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYTVSIYGVELIYHGWLDAVFSNPLSAIFTT 
               
               
                   
               
               
                 838 
                 PRT 
                 Artificial 
                 Luk38V85A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYTVSIYGVELIYHGWLDFAFSNPLSAIFTT 
               
               
                   
               
               
                 839 
                 PRT 
                 Artificial 
                 Luk38F86A 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYTVSIYGVELIYHGWLDFVASNPLSAIFTT 
               
               
                   
               
               
                 840 
                 PRT 
                 Human 
                 CR-5133LC 
                 EIVLTQSPATLSLSPGERATLSCRASQSVSGYL 
               
               
                   
                   
                   
                   
                 GWYQQKPGQAPRLLIYGASSRATGIPDRFSG 
               
               
                   
                   
                   
                   
                 SGSGTDFTLTISRLEPEDFAVYYCQQYGSSPL 
               
               
                   
                   
                   
                   
                 TFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGT 
               
               
                   
                   
                   
                   
                 ASVVCLLNNFYPREAKVQWKVDNALQSGNS 
               
               
                   
                   
                   
                   
                 QESVTEQDSKDSTYSLSSTLTLSKADYEKHK 
               
               
                   
                   
                   
                   
                 VYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 841 
                 PRT 
                 Human 
                 ProteinA3LC 
                 EIVLTQSPATLSLSPGERATLSCRASQSVADD 
               
               
                   
                   
                   
                   
                 LAWYQQKPGQAPRLLIYFASNRATGIPARFS 
               
               
                   
                   
                   
                   
                 GSGSGTDFTLTISSLEPEDFAVYYCQQRYGW 
               
               
                   
                   
                   
                   
                 PWTFGQGTKVEIKRTVAAPSVFIFPPSDEQLK 
               
               
                   
                   
                   
                   
                 SGTASVVCLLNNFYPREAKVQWKVDNALQS 
               
               
                   
                   
                   
                   
                 GNSQESVTEQDSKDSTYSLSSTLTLSKADYEK 
               
               
                   
                   
                   
                   
                 HKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 842 
                 PRT 
                 Human 
                 ProteinA9LC 
                 EIVLTQSPATLSLSPGERATLSCRASQSVSNAL 
               
               
                   
                   
                   
                   
                 AWYQQKPGQAPRLLIYGAGNRATGIPARFSG 
               
               
                   
                   
                   
                   
                 SGSGTDFTLTISSLEPEDFAVYYCQQRHNWPR 
               
               
                   
                   
                   
                   
                 TFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSG 
               
               
                   
                   
                   
                   
                 TASVVCLLNNFYPREAKVQWKVDNALQSGN 
               
               
                   
                   
                   
                   
                 SQESVTEQDSKDSTYSLSSTLTLSKADYEKHK 
               
               
                   
                   
                   
                   
                 VYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 843 
                 PRT 
                 Human 
                 RSVLC 
                 DIVMTQSPDSLAVSLGERATINCRASQSVDY 
               
               
                   
                   
                   
                   
                 NGISYMHWYQQKPGQPPKLLIYAASNPESGV 
               
               
                   
                   
                   
                   
                 PDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQ 
               
               
                   
                   
                   
                   
                 IIEDPWTFGQGTKVEIKRTVAAPSVFIFPPSDE 
               
               
                   
                   
                   
                   
                 QLKSGTASVVCLLNNFYPREAKVQWKVDNA 
               
               
                   
                   
                   
                   
                 LQSGNSQESVTEQDSKDSTYSLSSTLTLSKAD 
               
               
                   
                   
                   
                   
                 YEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 844 
                 PRT 
                 Human 
                 CSD7LC 
                 EIVMTQSPATLSVSPGERATLSCRASQYVSDN 
               
               
                   
                   
                   
                   
                 LAWYQQKPGQAPRLLIYGASTRATGVPARFS 
               
               
                   
                   
                   
                   
                 GSGSGTEFTLTISSLQSEDFAVYYCQQYNNW 
               
               
                   
                   
                   
                   
                 RPVTFGQGTRLEIKRTVAAPSVFIFPPSDEQLK 
               
               
                   
                   
                   
                   
                 SGTASVVCLLNNFYPREAKVQWKVDNALQS 
               
               
                   
                   
                   
                   
                 GNSQESVTEQDSKDSTYSLSSTLTLSKADYEK 
               
               
                   
                   
                   
                   
                 HKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 845 
                 PRT 
                 Human 
                 CR-6526LC 
                 QSALTQPPSASGSPGQSVTISCTGTSSDVGGY 
               
               
                   
                   
                   
                   
                 NYVSWYQQRPGKAPKLMIYDVSNRPSGVSD 
               
               
                   
                   
                   
                   
                 RFSGSKSGNTASLTISGLQAEDEADYYCSSYT 
               
               
                   
                   
                   
                   
                 TGSTLVVFGGGTKLTVLGQPKAAPSVTLFPPS 
               
               
                   
                   
                   
                   
                 SEELQANKATLVCLISDFYPGAVTVAWKADS 
               
               
                   
                   
                   
                   
                 SPVKAGVETTTPSKQSNNKYAASSYLSLTPE 
               
               
                   
                   
                   
                   
                 QWKSHRSYSCQVTHEGSTVEKTVAPTECS 
               
               
                   
               
               
                 846 
                 PRT 
                 Human 
                 PagibaximabLC 
                 DIVLSQSPAILSASPGEKVTMTCRASSSVNYM 
               
               
                   
                   
                   
                   
                 HWYQQKPGSSPKPWISATSNLASGVPARFSG 
               
               
                   
                   
                   
                   
                 SGSGTSYSLTISRVEAEDAATYYCQQWSSNPP 
               
               
                   
                   
                   
                   
                 TFGGGTMLEIKRTVAAPSVFIFPPSDEQLKSG 
               
               
                   
                   
                   
                   
                 TASVVCLLNNFYPREAKVQWKVDNALQSGN 
               
               
                   
                   
                   
                   
                 SQESVTEQDSKDSTYSLSSTLTLSKADYEKHK 
               
               
                   
                   
                   
                   
                 VYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 847 
                 PRT 
                 Human 
                 CR-6171LC 
                 QSVLTQPPSLSVSPGQTASISCSGDKLGDKYV 
               
               
                   
                   
                   
                   
                 SWYQQRPGQSPVLVIYHDTKRPSGIPERFSGT 
               
               
                   
                   
                   
                   
                 NSGNTATLTISGTQILDEADYYCQVWDRSTV 
               
               
                   
                   
                   
                   
                 VFGGGTQLTVLGQPKAAPSVTLFPPSSEELQA 
               
               
                   
                   
                   
                   
                 NKATLVCLISDFYPGAVTVAWKADSSPVKA 
               
               
                   
                   
                   
                   
                 GVETTTPSKQSNNKYAASSYLSLTPEQWKSH 
               
               
                   
                   
                   
                   
                 RSYSCQVTHEGSTVEKTVAPTECS 
               
               
                   
               
               
                 848 
                 PRT 
                 Human 
                 CR-5133HC66 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                   
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 849 
                 PRT 
                 Human 
                 CR-5133HC67 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                   
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSLPAPKNLVVSRVTEDSARLSWTAPDA 
               
               
                   
                   
                   
                   
                 AFDSFHIEYAEPWVWGEAIVLTVPGSERSYD 
               
               
                   
                   
                   
                   
                 LTGLKPGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 850 
                 PRT 
                 Human 
                 CR-5133HC68 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                   
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFPIVYQEWQFYGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYLVDIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 851 
                 PRT 
                 Human 
                 CR-5133HC69 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                   
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSLPAPKNLVVSRVTEDSARLSWTAPDA 
               
               
                   
                   
                   
                   
                 AFDSFPIVYQEWQFYGEAIVLTVPGSERSYDL 
               
               
                   
                   
                   
                   
                 TGLKPGTEYLVDIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 852 
                 PRT 
                 Human 
                 CR-5133HC70 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                   
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFWITYEEKFYRGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYKVWIVGVKGGQGSWPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSMLPAPKNL 
               
               
                   
                   
                   
                   
                 VVSRVTEDSARLSWTAPDAAFDSFHIEYAEP 
               
               
                   
                   
                   
                   
                 WVWGEAIVLTVPGSERSYDLTGLKPGTEYV 
               
               
                   
                   
                   
                   
                 VFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 853 
                 PRT 
                 Human 
                 CR-5133HC71 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                   
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFWITYEEKFYRGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYKVWIVGVKGGQGSWPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSLPAPKNLV 
               
               
                   
                   
                   
                   
                 VSRVTEDSARLSWTAPDAAFDSFHIEYAEPW 
               
               
                   
                   
                   
                   
                 VWGEAIVLTVPGSERSYDLTGLKPGTEYVVFI 
               
               
                   
                   
                   
                   
                 GGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 854 
                 PRT 
                 Human 
                 CR-5133HC72 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                   
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFWITYEEKFYRGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYKVWIVGVKGGQGSWPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSMLPAPKNL 
               
               
                   
                   
                   
                   
                 VVSRVTEDSARLSWTAPDAAFDSFPIVYQEW 
               
               
                   
                   
                   
                   
                 QFYGEAIVLTVPGSERSYDLTGLKPGTEYLV 
               
               
                   
                   
                   
                   
                 DIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 855 
                 PRT 
                 Human 
                 CR-5133HC73 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                   
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFWITYEEKFYRGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYKVWIVGVKGGQGSWPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSLPAPKNLV 
               
               
                   
                   
                   
                   
                 VSRVTEDSARLSWTAPDAAFDSFPIVYQEWQ 
               
               
                   
                   
                   
                   
                 FYGEAIVLTVPGSERSYDLTGLKPGTEYLVDI 
               
               
                   
                   
                   
                   
                 YGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 856 
                 PRT 
                 Human 
                 CR-5133HC74 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                   
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSMLPAPKNL 
               
               
                   
                   
                   
                   
                 VVSRVTEDSARLSWTAPDAAFDSFWITYEEK 
               
               
                   
                   
                   
                   
                 FYRGEAIVLTVPGSERSYDLTGLKPGTEYKV 
               
               
                   
                   
                   
                   
                 WIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 857 
                 PRT 
                 Human 
                 CR-5133HC75 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                   
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSLPAPKNLVVSRVTEDSARLSWTAPDA 
               
               
                   
                   
                   
                   
                 AFDSFHIEYAEPWVWGEAIVLTVPGSERSYD 
               
               
                   
                   
                   
                   
                 LTGLKPGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSGGGGSMLPAPKNLVV 
               
               
                   
                   
                   
                   
                 SRVTEDSARLSWTAPDAAFDSFWITYEEKFY 
               
               
                   
                   
                   
                   
                 RGEAIVLTVPGSERSYDLTGLKPGTEYKVWI 
               
               
                   
                   
                   
                   
                 VGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 858 
                 PRT 
                 Human 
                 CR-5133HC76 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                   
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFPIVYQEWQFYGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYLVDIYGVKGGSWSYPLSAIFT 
               
               
                   
                   
                   
                   
                 TGGGGSGGGGSGGGGSGGGGSMLPAPKNLV 
               
               
                   
                   
                   
                   
                 VSRVTEDSARLSWTAPDAAFDSFWITYEEKF 
               
               
                   
                   
                   
                   
                 YRGEAIVLTVPGSERSYDLTGLKPGTEYKVW 
               
               
                   
                   
                   
                   
                 IVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 859 
                 PRT 
                 Human 
                 CR-5133HC77 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                   
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSLPAPKNLVVSRVTEDSARLSWTAPDA 
               
               
                   
                   
                   
                   
                 AFDSFPIVYQEWQFYGEAIVLTVPGSERSYDL 
               
               
                   
                   
                   
                   
                 TGLKPGTEYLVDIYGVKGGSWSYPLSAIFTTG 
               
               
                   
                   
                   
                   
                 GGGSGGGGSGGGGSGGGGSMLPAPKNLVVS 
               
               
                   
                   
                   
                   
                 RVTEDSARLSWTAPDAAFDSFWITYEEKFYR 
               
               
                   
                   
                   
                   
                 GEAIVLTVPGSERSYDLTGLKPGTEYKVWIV 
               
               
                   
                   
                   
                   
                 GVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 860 
                 PRT 
                 Human 
                 ProteinA3HC78 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SMLPAPKNLVVSRVTEDSARLSWTAPDAAFD 
               
               
                   
                   
                   
                   
                 SFHIEYAEPWVWGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                   
                 LKPGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 861 
                 PRT 
                 Human 
                 ProteinA3HC79 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYAEPWVWGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYVVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 862 
                 PRT 
                 Human 
                 ProteinA3HC80 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SMLPAPKNLVVSRVTEDSARLSWTAPDAAFD 
               
               
                   
                   
                   
                   
                 SFPIVYQEWQFYGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYLVDIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 863 
                 PRT 
                 Human 
                 ProteinA3HC81 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FPIVYQEWQFYGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYLVDIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 864 
                 PRT 
                 Human 
                 ProteinA3HC82 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SMLPAPKNLVVSRVTEDSARLSWTAPDAAFD 
               
               
                   
                   
                   
                   
                 SFWITYEEKFYRGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYKVWIVGVKGGQGSWPLSAIFTTGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSGGGGSGGGGSMLPAPKNLVVSRV 
               
               
                   
                   
                   
                   
                 TEDSARLSWTAPDAAFDSFHIEYAEPWVWGE 
               
               
                   
                   
                   
                   
                 AIVLTVPGSERSYDLTGLKPGTEYVVFIGGVK 
               
               
                   
                   
                   
                   
                 GGHNSTPLSAIFTT 
               
               
                   
               
               
                 865 
                 PRT 
                 Human 
                 ProteinA3HC83 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SMLPAPKNLVVSRVTEDSARLSWTAPDAAFD 
               
               
                   
                   
                   
                   
                 SFWITYEEKFYRGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYKVWIVGVKGGQGSWPLSAIFTTGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSGGGGSGGGGSLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFHIEYAEPWVWGE 
               
               
                   
                   
                   
                   
                 AIVLTVPGSERSYDLTGLKPGTEYVVFIGGVK 
               
               
                   
                   
                   
                   
                 GGHNSTPLSAIFTT 
               
               
                   
               
               
                 866 
                 PRT 
                 Human 
                 ProteinA3HC84 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SMLPAPKNLVVSRVTEDSARLSWTAPDAAFD 
               
               
                   
                   
                   
                   
                 SFWITYEEKFYRGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYKVWIVGVKGGQGSWPLSAIFTTGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSGGGGSGGGGSMLPAPKNLVVSRV 
               
               
                   
                   
                   
                   
                 TEDSARLSWTAPDAAFDSFPIVYQEWQFYGE 
               
               
                   
                   
                   
                   
                 AIVLTVPGSERSYDLTGLKPGTEYLVDIYGVK 
               
               
                   
                   
                   
                   
                 GGSWSYPLSAIFTT 
               
               
                   
               
               
                 867 
                 PRT 
                 Human 
                 ProteinA3HC85 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SMLPAPKNLVVSRVTEDSARLSWTAPDAAFD 
               
               
                   
                   
                   
                   
                 SFWITYEEKFYRGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYKVWIVGVKGGQGSWPLSAIFTTGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSGGGGSGGGGSLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFPIVYQEWQFYGEA 
               
               
                   
                   
                   
                   
                 IVLTVPGSERSYDLTGLKPGTEYLVDIYGVKG 
               
               
                   
                   
                   
                   
                 GSWSYPLSAIFTT 
               
               
                   
               
               
                 868 
                 PRT 
                 Human 
                 ProteinA3HC86 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SMLPAPKNLVVSRVTEDSARLSWTAPDAAFD 
               
               
                   
                   
                   
                   
                 SFHIEYAEPWVWGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                   
                 LKPGTEYVVFIGGVKGGHNSTPLSAIFTTGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSGGGGSGGGGSMLPAPKNLVVSRV 
               
               
                   
                   
                   
                   
                 TEDSARLSWTAPDAAFDSFWITYEEKFYRGE 
               
               
                   
                   
                   
                   
                 AIVLTVPGSERSYDLTGLKPGTEYKVWIVGV 
               
               
                   
                   
                   
                   
                 KGGQGSWPLSAIFTT 
               
               
                   
               
               
                 869 
                 PRT 
                 Human 
                 ProteinA3HC87 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYAEPWVWGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYVVFIGGVKGGHNSTPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFWITYEEKFYRGEA 
               
               
                   
                   
                   
                   
                 IVLTVPGSERSYDLTGLKPGTEYKVWIVGVK 
               
               
                   
                   
                   
                   
                 GGQGSWPLSAIFTT 
               
               
                   
               
               
                 870 
                 PRT 
                 Human 
                 ProteinA3HC88 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SMLPAPKNLVVSRVTEDSARLSWTAPDAAFD 
               
               
                   
                   
                   
                   
                 SFPIVYQEWQFYGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYLVDIYGVKGGSWSYPLSAIFTTGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSGGGGSGGGGSMLPAPKNLVVSRV 
               
               
                   
                   
                   
                   
                 TEDSARLSWTAPDAAFDSFWITYEEKFYRGE 
               
               
                   
                   
                   
                   
                 AIVLTVPGSERSYDLTGLKPGTEYKVWIVGV 
               
               
                   
                   
                   
                   
                 KGGQGSWPLSAIFTT 
               
               
                   
               
               
                 871 
                 PRT 
                 Human 
                 ProteinA3HC89 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FPIVYQEWQFYGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYLVDIYGVKGGSWSYPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFWITYEEKFYRGEA 
               
               
                   
                   
                   
                   
                 IVLTVPGSERSYDLTGLKPGTEYKVWIVGVK 
               
               
                   
                   
                   
                   
                 GGQGSWPLSAIFTT 
               
               
                   
               
               
                 872 
                 PRT 
                 Human 
                 ProteinA9HC90 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFHIEYAEPWVWGEAIVLTVPGSE 
               
               
                   
                   
                   
                   
                 RSYDLTGLKPGTEYVVFIGGVKGGHNSTPLS 
               
               
                   
                   
                   
                   
                 AIFTT 
               
               
                   
               
               
                 873 
                 PRT 
                 Human 
                 ProteinA9HC91 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 874 
                 PRT 
                 Human 
                 ProteinA9HC92 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFPIVYQEWQFYGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYLVDIYGVKGGSWSYPLSA 
               
               
                   
                   
                   
                   
                 IFTT 
               
               
                   
               
               
                 875 
                 PRT 
                 Human 
                 ProteinA9HC93 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFPIVYQEWQFYGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYLVDIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 876 
                 PRT 
                 Human 
                 ProteinA9HC94 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFWITYEEKFYRGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYKVWIVGVKGGQGSWPLS 
               
               
                   
                   
                   
                   
                 AIFTTGGGGSGGGGSGGGGSGGGGSMLPAPK 
               
               
                   
                   
                   
                   
                 NLVVSRVTEDSARLSWTAPDAAFDSFHIEYA 
               
               
                   
                   
                   
                   
                 EPWVWGEAIVLTVPGSERSYDLTGLKPGTEY 
               
               
                   
                   
                   
                   
                 VVFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 877 
                 PRT 
                 Human 
                 ProteinA9HC95 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFWITYEEKFYRGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYKVWIVGVKGGQGSWPLS 
               
               
                   
                   
                   
                   
                 AIFTTGGGGSGGGGSGGGGSGGGGSLPAPKN 
               
               
                   
                   
                   
                   
                 LVVSRVTEDSARLSWTAPDAAFDSFHIEYAE 
               
               
                   
                   
                   
                   
                 PWVWGEAIVLTVPGSERSYDLTGLKPGTEYV 
               
               
                   
                   
                   
                   
                 VFIGGVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 878 
                 PRT 
                 Human 
                 ProteinA9HC96 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFWITYEEKFYRGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYKVWIVGVKGGQGSWPLS 
               
               
                   
                   
                   
                   
                 AIFTTGGGGSGGGGSGGGGSGGGGSMLPAPK 
               
               
                   
                   
                   
                   
                 NLVVSRVTEDSARLSWTAPDAAFDSFPIVYQ 
               
               
                   
                   
                   
                   
                 EWQFYGEAIVLTVPGSERSYDLTGLKPGTEY 
               
               
                   
                   
                   
                   
                 LVDIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 879 
                 PRT 
                 Human 
                 ProteinA9HC97 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFWITYEEKFYRGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYKVWIVGVKGGQGSWPLS 
               
               
                   
                   
                   
                   
                 AIFTTGGGGSGGGGSGGGGSGGGGSLPAPKN 
               
               
                   
                   
                   
                   
                 LVVSRVTEDSARLSWTAPDAAFDSFPIVYQE 
               
               
                   
                   
                   
                   
                 WQFYGEAIVLTVPGSERSYDLTGLKPGTEYL 
               
               
                   
                   
                   
                   
                 VDIYGVKGGSWSYPLSAIFTT 
               
               
                   
               
               
                 880 
                 PRT 
                 Human 
                 ProteinA9HC98 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFHIEYAEPWVWGEAIVLTVPGSE 
               
               
                   
                   
                   
                   
                 RSYDLTGLKPGTEYVVFIGGVKGGHNSTPLS 
               
               
                   
                   
                   
                   
                 AIFTTGGGGSGGGGSGGGGSGGGGSMLPAPK 
               
               
                   
                   
                   
                   
                 NLVVSRVTEDSARLSWTAPDAAFDSFWITYE 
               
               
                   
                   
                   
                   
                 EKFYRGEAIVLTVPGSERSYDLTGLKPGTEYK 
               
               
                   
                   
                   
                   
                 VWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 881 
                 PRT 
                 Human 
                 ProteinA9HC99 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSMLPAPKNL 
               
               
                   
                   
                   
                   
                 VVSRVTEDSARLSWTAPDAAFDSFWITYEEK 
               
               
                   
                   
                   
                   
                 FYRGEAIVLTVPGSERSYDLTGLKPGTEYKV 
               
               
                   
                   
                   
                   
                 WIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 882 
                 PRT 
                 Human 
                 ProteinA9HC100 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFPIVYQEWQFYGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYLVDIYGVKGGSWSYPLSA 
               
               
                   
                   
                   
                   
                 IFTTGGGGSGGGGSGGGGSGGGGSMLPAPKN 
               
               
                   
                   
                   
                   
                 LVVSRVTEDSARLSWTAPDAAFDSFWITYEE 
               
               
                   
                   
                   
                   
                 KFYRGEAIVLTVPGSERSYDLTGLKPGTEYK 
               
               
                   
                   
                   
                   
                 VWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 883 
                 PRT 
                 Human 
                 ProteinA9HC101 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFPIVYQEWQFYGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYLVDIYGVKGGSWSYPLSAIFT 
               
               
                   
                   
                   
                   
                 TGGGGSGGGGSGGGGSGGGGSMLPAPKNLV 
               
               
                   
                   
                   
                   
                 VSRVTEDSARLSWTAPDAAFDSFWITYEEKF 
               
               
                   
                   
                   
                   
                 YRGEAIVLTVPGSERSYDLTGLKPGTEYKVW 
               
               
                   
                   
                   
                   
                 IVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 884 
                 PRT 
                 Human 
                 RSVHC102 
                 QITLKESGPTLVKPTQTLTLTCTFSGFSLSTSG 
               
               
                   
                   
                   
                   
                 MGVSWIRQPPGKALEWLAHIYWDDDKRYNP 
               
               
                   
                   
                   
                   
                 SLKSRLTITKDTSKNQVVLTMTNMDPVDTAT 
               
               
                   
                   
                   
                   
                 YYCARLYGFTYGFAYWGQGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSS 
               
               
                   
                   
                   
                   
                 VVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 
               
               
                   
                   
                   
                   
                 EPKSCDKTHTCPPCPAPELLGGPSVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNKALPAPIEKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNHYTQKSLSLSPGKGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSLPAPKNLVVSRVTEDSARLSWTAPD 
               
               
                   
                   
                   
                   
                 AAFDSFLIQYQESEKVGEAIVLTVPGSERSYD 
               
               
                   
                   
                   
                   
                 LTGLKPGTEYTVSIYGVKGGHRSNPLSAIFTT 
               
               
                   
               
               
                 885 
                 PRT 
                 Human 
                 RSVHC103 
                 QITLKESGPTLVKPTQTLTLTCTFSGFSLSTSG 
               
               
                   
                   
                   
                   
                 MGVSWIRQPPGKALEWLAHIYWDDDKRYNP 
               
               
                   
                   
                   
                   
                 SLKSRLTITKDTSKNQVVLTMTNMDPVDTAT 
               
               
                   
                   
                   
                   
                 YYCARLYGFTYGFAYWGQGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSS 
               
               
                   
                   
                   
                   
                 VVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 
               
               
                   
                   
                   
                   
                 EPKSCDKTHTCPPCPAPELLGGPSVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNKALPAPIEKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSLPAPKNLVVSRVTEDSARLSWTAPDA 
               
               
                   
                   
                   
                   
                 AFDSFLIQYQESEKVGEAIVLTVPGSERSYDL 
               
               
                   
                   
                   
                   
                 TGLKPGTEYTVSIYGVKGGHRSNPLSAIFTT 
               
               
                   
               
               
                 886 
                 PRT 
                 Human 
                 RSVHC104 
                 QITLKESGPTLVKPTQTLTLTCTFSGFSLSTSG 
               
               
                   
                   
                   
                   
                 MGVSWIRQPPGKALEWLAHIYWDDDKRYNP 
               
               
                   
                   
                   
                   
                 SLKSRLTITKDTSKNQVVLTMTNMDPVDTAT 
               
               
                   
                   
                   
                   
                 YYCARLYGFTYGFAYWGQGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSS 
               
               
                   
                   
                   
                   
                 VVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 
               
               
                   
                   
                   
                   
                 EPKSCDKTHTCPPCPAPPVAGPDVFLFPPKPK 
               
               
                   
                   
                   
                   
                 DTLMISRTPEVTCVVVDVSHEDPEVKFNWYV 
               
               
                   
                   
                   
                   
                 DGVEVHNAKTKPREEQYNSTYRVVSVLTVL 
               
               
                   
                   
                   
                   
                 HQDWLNGKEYKCKVSNAALPAPIAKTISKAK 
               
               
                   
                   
                   
                   
                 GQPREPQVYTLPPSRDELTKNQVSLTCLVKG 
               
               
                   
                   
                   
                   
                 FYPSDIAVEWESNGQPENNYKTTPPVLDSDG 
               
               
                   
                   
                   
                   
                 SFFLYSKLTVDKSRWQQGNVFSCSVMHEAL 
               
               
                   
                   
                   
                   
                 HNHYTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSLPAPKNLVVSRVTEDSARLSWTAPDA 
               
               
                   
                   
                   
                   
                 AFDSFLIQYQESEKVGEAIVLTVPGSERSYDL 
               
               
                   
                   
                   
                   
                 TGLKPGTEYTVSIYGVKGGHRSNPLSAIFTT 
               
               
                   
               
               
                 887 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC113 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNHYTQKSLSLSPGKGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSMLPAPKNL 
               
               
                   
                   
                   
                   
                 VVSRVTEDSARLSWTAPDAAFDSFWITYEEK 
               
               
                   
                   
                   
                   
                 FYRGEAIVLTVPGSERSYDLTGLKPGTEYKV 
               
               
                   
                   
                   
                   
                 WIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 888 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC114 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNHYTQKSLSLSPGKGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSLPAPKNLVVSRVTEDSARLSWTAPD 
               
               
                   
                   
                   
                   
                 AAFDSFHIEYAEPWVWGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYVVFIGGVKGGHNSTPLSAIFT 
               
               
                   
                   
                   
                   
                 TGGGGSGGGGSGGGGSGGGGSMLPAPKNLV 
               
               
                   
                   
                   
                   
                 VSRVTEDSARLSWTAPDAAFDSFWITYEEKF 
               
               
                   
                   
                   
                   
                 YRGEAIVLTVPGSERSYDLTGLKPGTEYKVW 
               
               
                   
                   
                   
                   
                 IVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 889 
                 PRT 
                 Human 
                 ProteinA3HC115 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNHY 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SMLPAPKNLVVSRVTEDSARLSWTAPDAAFD 
               
               
                   
                   
                   
                   
                 SFHIEYAEPWVWGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                   
                 LKPGTEYVVFIGGVKGGHNSTPLSAIFTTGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSGGGGSGGGGSMLPAPKNLVVSRV 
               
               
                   
                   
                   
                   
                 TEDSARLSWTAPDAAFDSFWITYEEKFYRGE 
               
               
                   
                   
                   
                   
                 AIVLTVPGSERSYDLTGLKPGTEYKVWIVGV 
               
               
                   
                   
                   
                   
                 KGGQGSWPLSAIFTT 
               
               
                   
               
               
                 890 
                 PRT 
                 Human 
                 ProteinA3HC116 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNHY 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYAEPWVWGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYVVFIGGVKGGHNSTPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFWITYEEKFYRGEA 
               
               
                   
                   
                   
                   
                 IVLTVPGSERSYDLTGLKPGTEYKVWIVGVK 
               
               
                   
                   
                   
                   
                 GGQGSWPLSAIFTT 
               
               
                   
               
               
                 891 
                 PRT 
                 Human 
                 ProteinA9HC117 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNHYTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFHIEYAEPWVWGEAIVLTVPGSE 
               
               
                   
                   
                   
                   
                 RSYDLTGLKPGTEYVVFIGGVKGGHNSTPLS 
               
               
                   
                   
                   
                   
                 AIFTTGGGGSGGGGSGGGGSGGGGSMLPAPK 
               
               
                   
                   
                   
                   
                 NLVVSRVTEDSARLSWTAPDAAFDSFWITYE 
               
               
                   
                   
                   
                   
                 EKFYRGEAIVLTVPGSERSYDLTGLKPGTEYK 
               
               
                   
                   
                   
                   
                 VWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 892 
                 PRT 
                 Human 
                 ProteinA9HC118 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNHYTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSMLPAPKNL 
               
               
                   
                   
                   
                   
                 VVSRVTEDSARLSWTAPDAAFDSFWITYEEK 
               
               
                   
                   
                   
                   
                 FYRGEAIVLTVPGSERSYDLTGLKPGTEYKV 
               
               
                   
                   
                   
                   
                 WIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 893 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC119 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGGGGGSGGGGSGGGGSG 
               
               
                   
                   
                   
                   
                 GGGSMLPAPKNLVVSRVTEDSARLSWTAPD 
               
               
                   
                   
                   
                   
                 AAFDSFHIEYAEPWVWGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYVVFIGGVKGGHNSTPLSAIFT 
               
               
                   
                   
                   
                   
                 TGGGGSGGGGSGGGGSGGGGSMLPAPKNLV 
               
               
                   
                   
                   
                   
                 VSRVTEDSARLSWTAPDAAFDSFWITYEEKF 
               
               
                   
                   
                   
                   
                 YRGEAIVLTVPGSERSYDLTGLKPGTEYKVW 
               
               
                   
                   
                   
                   
                 IVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 894 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC120 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNHYTQKSLSLSPGGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSMLPAPKNL 
               
               
                   
                   
                   
                   
                 VVSRVTEDSARLSWTAPDAAFDSFWITYEEK 
               
               
                   
                   
                   
                   
                 FYRGEAIVLTVPGSERSYDLTGLKPGTEYKV 
               
               
                   
                   
                   
                   
                 WIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 895 
                 PRT 
                 Human 
                 RSVHC121 
                 QITLKESGPTLVKPTQTLTLTCTFSGFSLSTSG 
               
               
                   
                   
                   
                   
                 MGVSWIRQPPGKALEWLAHIYWDDDKRYNP 
               
               
                   
                   
                   
                   
                 SLKSRLTITKDTSKNQVVLTMTNMDPVDTAT 
               
               
                   
                   
                   
                   
                 YYCARLYGFTYGFAYWGQGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSS 
               
               
                   
                   
                   
                   
                 VVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 
               
               
                   
                   
                   
                   
                 EPKSCDKTHTCPPCPAPPVAGPDVFLFPPKPK 
               
               
                   
                   
                   
                   
                 DTLMISRTPEVTCVVVDVSHEDPEVKFNWYV 
               
               
                   
                   
                   
                   
                 DGVEVHNAKTKPREEQYNSTYRVVSVLTVL 
               
               
                   
                   
                   
                   
                 HQDWLNGKEYKCKVSNAALPAPIAKTISKAK 
               
               
                   
                   
                   
                   
                 GQPREPQVYTLPPSRDELTKNQVSLTCLVKG 
               
               
                   
                   
                   
                   
                 FYPSDIAVEWESNGQPENNYKTTPPVLDSDG 
               
               
                   
                   
                   
                   
                 SFFLYSKLTVDKSRWQQGNVFSCSVMHEAL 
               
               
                   
                   
                   
                   
                 HNRFTQKSLSLSPGKGGGGSGGGGSGGGGSG 
               
               
                   
                   
                   
                   
                 GGGSMLPAPKNLVVSRVTEDSARLSWTAPD 
               
               
                   
                   
                   
                   
                 AAFDSFLIQYQESEKVGEAIVLTVPGSERSYD 
               
               
                   
                   
                   
                   
                 LTGLKPGTEYTVSIYGVKGGHRSNPLSAIFTT 
               
               
                   
               
               
                 896 
                 PRT 
                 Human 
                 RSVHC122 
                 QITLKESGPTLVKPTQTLTLTCTFSGFSLSTSG 
               
               
                   
                   
                   
                   
                 MGVSWIRQPPGKALEWLAHIYWDDDKRYNP 
               
               
                   
                   
                   
                   
                 SLKSRLTITKDTSKNQVVLTMTNMDPVDTAT 
               
               
                   
                   
                   
                   
                 YYCARLYGFTYGFAYWGQGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSS 
               
               
                   
                   
                   
                   
                 VVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 
               
               
                   
                   
                   
                   
                 EPKSCDKTHTCPPCPAPPVAGPDVFLFPPKPK 
               
               
                   
                   
                   
                   
                 DTLMISRTPEVTCVVVDVSHEDPEVKFNWYV 
               
               
                   
                   
                   
                   
                 DGVEVHNAKTKPREEQYNSTYRVVSVLTVL 
               
               
                   
                   
                   
                   
                 HQDWLNGKEYKCKVSNAALPAPIAKTISKAK 
               
               
                   
                   
                   
                   
                 GQPREPQVYTLPPSRDELTKNQVSLTCLVKG 
               
               
                   
                   
                   
                   
                 FYPSDIAVEWESNGQPENNYKTTPPVLDSDG 
               
               
                   
                   
                   
                   
                 SFFLYSKLTVDKSRWQQGNVFSCSVMHEAL 
               
               
                   
                   
                   
                   
                 HNRFTQKSLSLSPGKGGGGSGGGGSGGGGSG 
               
               
                   
                   
                   
                   
                 GGGSLPAPKNLVVSRVTEDSARLSWTAPDAA 
               
               
                   
                   
                   
                   
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                   
                 GLKPGTEYTVSIYGVKGGHRSNPLSAIFTTGG 
               
               
                   
                   
                   
                   
                 GGSGGGGSGGGGSGGGGSLPAPKNLVVSRV 
               
               
                   
                   
                   
                   
                 TEDSARLSWTAPDAAFDSFLIQYQESEKVGE 
               
               
                   
                   
                   
                   
                 AIVLTVPGSERSYDLTGLKPGTEYTVSIYGVK 
               
               
                   
                   
                   
                   
                 GGHRSNPLSAIFTT 
               
               
                   
               
               
                 897 
                 PRT 
                 Human 
                 RSVHC123 
                 QITLKESGPTLVKPTQTLTLTCTFSGFSLSTSG 
               
               
                   
                   
                   
                   
                 MGVSWIRQPPGKALEWLAHIYWDDDKRYNP 
               
               
                   
                   
                   
                   
                 SLKSRLTITKDTSKNQVVLTMTNMDPVDTAT 
               
               
                   
                   
                   
                   
                 YYCARLYGFTYGFAYWGQGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSS 
               
               
                   
                   
                   
                   
                 VVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 
               
               
                   
                   
                   
                   
                 EPKSCDKTHTCPPCPAPPVAGPDVFLFPPKPK 
               
               
                   
                   
                   
                   
                 DTLMISRTPEVTCVVVDVSHEDPEVKFNWYV 
               
               
                   
                   
                   
                   
                 DGVEVHNAKTKPREEQYNSTYRVVSVLTVL 
               
               
                   
                   
                   
                   
                 HQDWLNGKEYKCKVSNAALPAPIAKTISKAK 
               
               
                   
                   
                   
                   
                 GQPREPQVYTLPPSRDELTKNQVSLTCLVKG 
               
               
                   
                   
                   
                   
                 FYPSDIAVEWESNGQPENNYKTTPPVLDSDG 
               
               
                   
                   
                   
                   
                 SFFLYSKLTVDKSRWQQGNVFSCSVMHEAL 
               
               
                   
                   
                   
                   
                 HNRFTQKSLSLSPGKGGGGSGGGGSGGGGSG 
               
               
                   
                   
                   
                   
                 GGGSMLPAPKNLVVSRVTEDSARLSWTAPD 
               
               
                   
                   
                   
                   
                 AAFDSFLIQYQESEKVGEAIVLTVPGSERSYD 
               
               
                   
                   
                   
                   
                 LTGLKPGTEYTVSIYGVKGGHRSNPLSAIFTT 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSGGGGSMLPAPKNLVV 
               
               
                   
                   
                   
                   
                 SRVTEDSARLSWTAPDAAFDSFLIQYQESEK 
               
               
                   
                   
                   
                   
                 VGEAIVLTVPGSERSYDLTGLKPGTEYTVSIY 
               
               
                   
                   
                   
                   
                 GVKGGHRSNPLSAIFTT 
               
               
                   
               
               
                 898 
                 PRT 
                 Human 
                 ProteinA3HC124 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SMLPAPKNLVVSRVTEDSARLSWTAPDAAFD 
               
               
                   
                   
                   
                   
                 SFWITYEEKFYRGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 899 
                 PRT 
                 Human 
                 ProteinA9HC125 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFWITYEEKFYRGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYKVWIVGVKGGQGSWPLS 
               
               
                   
                   
                   
                   
                 AIFTT 
               
               
                   
               
               
                 900 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC126 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFLIQYQESEKVGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYTVSIYGVELIYHGWLDFVFS 
               
               
                   
                   
                   
                   
                 NPLSAIFTT 
               
               
                   
               
               
                 901 
                 PRT 
                 Human 
                 ProteinA3HC127 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SMLPAPKNLVVSRVTEDSARLSWTAPDAAFD 
               
               
                   
                   
                   
                   
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYTVSIYGVELIYHGWLDFVFSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 902 
                 PRT 
                 Human 
                 ProteinA9HC128 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFLIQYQESEKVGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYTVSIYGVELIYHGWLDFV 
               
               
                   
                   
                   
                   
                 FSNPLSAIFTT 
               
               
                   
               
               
                 903 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC129 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSLPAPKNLVVSRVTEDSARLSWTAPDA 
               
               
                   
                   
                   
                   
                 AFDSFLIQYQESEKVGEAIVLTVPGSERSYDL 
               
               
                   
                   
                   
                   
                 TGLKPGTEYTVSIYGVELIYHGWLDFVFSNPL 
               
               
                   
                   
                   
                   
                 SAIFTT 
               
               
                   
               
               
                 904 
                 PRT 
                 Human 
                 ProteinA3HC130 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYTVSIYGVELIYHGWLDFVFSNPLSAIFTT 
               
               
                   
               
               
                 905 
                 PRT 
                 Human 
                 ProteinA9HC131 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFLIQYQESEKVGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYTVSIYGVELIYHGWLDFVFS 
               
               
                   
                   
                   
                   
                 NPLSAIFTT 
               
               
                   
               
               
                 906 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC132 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFWITYEEKFYRGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYKVWIVGVKGGQGSWPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSMLPAPKNL 
               
               
                   
                   
                   
                   
                 VVSRVTEDSARLSWTAPDAAFDSFLIQYQES 
               
               
                   
                   
                   
                   
                 EKVGEAIVLTVPGSERSYDLTGLKPGTEYTVS 
               
               
                   
                   
                   
                   
                 IYGVELIYHGWLDFVFSNPLSAIFTT 
               
               
                   
               
               
                 907 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC133 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFWITYEEKFYRGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYKVWIVGVKGGQGSWPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSLPAPKNLV 
               
               
                   
                   
                   
                   
                 VSRVTEDSARLSWTAPDAAFDSFLIQYQESE 
               
               
                   
                   
                   
                   
                 KVGEAIVLTVPGSERSYDLTGLKPGTEYTVSI 
               
               
                   
                   
                   
                   
                 YGVELIYHGWLDFVFSNPLSAIFTT 
               
               
                   
               
               
                 908 
                 PRT 
                 Human 
                 ProteinA3HC134 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SMLPAPKNLVVSRVTEDSARLSWTAPDAAFD 
               
               
                   
                   
                   
                   
                 SFWITYEEKFYRGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYKVWIVGVKGGQGSWPLSAIFTTGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSGGGGSGGGGSMLPAPKNLVVSRV 
               
               
                   
                   
                   
                   
                 TEDSARLSWTAPDAAFDSFLIQYQESEKVGE 
               
               
                   
                   
                   
                   
                 AIVLTVPGSERSYDLTGLKPGTEYTVSIYGVE 
               
               
                   
                   
                   
                   
                 LIYHGWLDFVFSNPLSAIFTT 
               
               
                   
               
               
                 909 
                 PRT 
                 Human 
                 ProteinA3HC135 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SMLPAPKNLVVSRVTEDSARLSWTAPDAAFD 
               
               
                   
                   
                   
                   
                 SFWITYEEKFYRGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYKVWIVGVKGGQGSWPLSAIFTTGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSGGGGSGGGGSLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFLIQYQESEKVGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYTVSIYGVELI 
               
               
                   
                   
                   
                   
                 YHGWLDFVFSNPLSAIFTT 
               
               
                   
               
               
                 910 
                 PRT 
                 Human 
                 ProteinA9HC136 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFWITYEEKFYRGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYKVWIVGVKGGQGSWPLS 
               
               
                   
                   
                   
                   
                 AIFTTGGGGSGGGGSGGGGSGGGGSMLPAPK 
               
               
                   
                   
                   
                   
                 NLVVSRVTEDSARLSWTAPDAAFDSFLIQYQ 
               
               
                   
                   
                   
                   
                 ESEKVGEAIVLTVPGSERSYDLTGLKPGTEYT 
               
               
                   
                   
                   
                   
                 VSIYGVELIYHGWLDFVFSNPLSAIFTT 
               
               
                   
               
               
                 911 
                 PRT 
                 Human 
                 ProteinA9HC137 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFWITYEEKFYRGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYKVWIVGVKGGQGSWPLS 
               
               
                   
                   
                   
                   
                 AIFTTGGGGSGGGGSGGGGSGGGGSLPAPKN 
               
               
                   
                   
                   
                   
                 LVVSRVTEDSARLSWTAPDAAFDSFLIQYQE 
               
               
                   
                   
                   
                   
                 SEKVGEAIVLTVPGSERSYDLTGLKPGTEYTV 
               
               
                   
                   
                   
                   
                 SIYGVELIYHGWLDFVFSNPLSAIFTT 
               
               
                   
               
               
                 912 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC138 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFLIQYQESEKVGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYTVSIYGVELIYHGWLDFVFS 
               
               
                   
                   
                   
                   
                 NPLSAIFTTGGGGSGGGGSGGGGSGGGGSML 
               
               
                   
                   
                   
                   
                 PAPKNLVVSRVTEDSARLSWTAPDAAFDSFW 
               
               
                   
                   
                   
                   
                 ITYEEKFYRGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                   
                 TEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 913 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC139 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSLPAPKNLVVSRVTEDSARLSWTAPDA 
               
               
                   
                   
                   
                   
                 AFDSFLIQYQESEKVGEAIVLTVPGSERSYDL 
               
               
                   
                   
                   
                   
                 TGLKPGTEYTVSIYGVELIYHGWLDFVFSNPL 
               
               
                   
                   
                   
                   
                 SAIFTTGGGGSGGGGSGGGGSGGGGSMLPAP 
               
               
                   
                   
                   
                   
                 KNLVVSRVTEDSARLSWTAPDAAFDSFWITY 
               
               
                   
                   
                   
                   
                 EEKFYRGEAIVLTVPGSERSYDLTGLKPGTEY 
               
               
                   
                   
                   
                   
                 KVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 914 
                 PRT 
                 Human 
                 ProteinA3HC140 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SMLPAPKNLVVSRVTEDSARLSWTAPDAAFD 
               
               
                   
                   
                   
                   
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYTVSIYGVELIYHGWLDFVFSNPLSAI 
               
               
                   
                   
                   
                   
                 FTTGGGGSGGGGSGGGGSGGGGSMLPAPKN 
               
               
                   
                   
                   
                   
                 LVVSRVTEDSARLSWTAPDAAFDSFWITYEE 
               
               
                   
                   
                   
                   
                 KFYRGEAIVLTVPGSERSYDLTGLKPGTEYK 
               
               
                   
                   
                   
                   
                 VWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 915 
                 PRT 
                 Human 
                 ProteinA3HC141 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGKGGGGSGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYTVSIYGVELIYHGWLDFVFSNPLSAIFT 
               
               
                   
                   
                   
                   
                 TGGGGSGGGGSGGGGSGGGGSMLPAPKNLV 
               
               
                   
                   
                   
                   
                 VSRVTEDSARLSWTAPDAAFDSFWITYEEKF 
               
               
                   
                   
                   
                   
                 YRGEAIVLTVPGSERSYDLTGLKPGTEYKVW 
               
               
                   
                   
                   
                   
                 IVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 916 
                 PRT 
                 Human 
                 ProteinA9HC142 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFLIQYQESEKVGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYTVSIYGVELIYHGWLDFV 
               
               
                   
                   
                   
                   
                 FSNPLSAIFTTGGGGSGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FWITYEEKFYRGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 917 
                 PRT 
                 Human 
                 ProteinA9HC143 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFLIQYQESEKVGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYTVSIYGVELIYHGWLDFVFS 
               
               
                   
                   
                   
                   
                 NPLSAIFTTGGGGSGGGGSGGGGSGGGGSML 
               
               
                   
                   
                   
                   
                 PAPKNLVVSRVTEDSARLSWTAPDAAFDSFW 
               
               
                   
                   
                   
                   
                 ITYEEKFYRGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                   
                 TEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 918 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC144 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSMLPAPKNL 
               
               
                   
                   
                   
                   
                 VVSRVTEDSARLSWTAPDAAFDSFWITYEEK 
               
               
                   
                   
                   
                   
                 FYRGEAIVLTVPGSERSYDLTGLKPGTEYKV 
               
               
                   
                   
                   
                   
                 WIVGVKGGQGSWPLSAIFTTDYKDDDDK 
               
               
                   
               
               
                 919 
                 PRT 
                 Human 
                 CR- 
                 EQKLISEEDLEVQLVETGGGLVKPGGSLRLSC 
               
               
                   
                   
                   
                 5133HC145 
                 SASRFSFRDYYMTWIRQAPGKGPEWVSHISG 
               
               
                   
                   
                   
                   
                 SGSTIYYADSVRGRFTISRDNAKSSLYLQMDS 
               
               
                   
                   
                   
                   
                 LQADDTAVYYCARGGRATSYYWVHWGPGT 
               
               
                   
                   
                   
                   
                 LVTVSSASTKGPSVFPLAPSSKSTSGGTAALG 
               
               
                   
                   
                   
                   
                 CLVKDYFPEPVTVSWNSGALTSGVHTFPAVL 
               
               
                   
                   
                   
                   
                 QSSGLYSLSSVVTVPSSSLGTQTYICNVNHKP 
               
               
                   
                   
                   
                   
                 SNTKVDKKVEPKSCDKTHTCPPCPAPPVAGP 
               
               
                   
                   
                   
                   
                 DVFLFPPKPKDTLMISRTPEVTCVVVDVSHED 
               
               
                   
                   
                   
                   
                 PEVKFNWYVDGVEVHNAKTKPREEQYNSTY 
               
               
                   
                   
                   
                   
                 RVVSVLTVLHQDWLNGKEYKCKVSNAALPA 
               
               
                   
                   
                   
                   
                 PIAKTISKAKGQPREPQVYTLPPSRDELTKNQ 
               
               
                   
                   
                   
                   
                 VSLTCLVKGFYPSDIAVEWESNGQPENNYKT 
               
               
                   
                   
                   
                   
                 TPPVLDSDGSFFLYSKLTVDKSRWQQGNVFS 
               
               
                   
                   
                   
                   
                 CSVMHEALHNRFTQKSLSLSPGKGGGGSGG 
               
               
                   
                   
                   
                   
                 GGSGGGGSGGGGSMLPAPKNLVVSRVTEDS 
               
               
                   
                   
                   
                   
                 ARLSWTAPDAAFDSFHIEYAEPWVWGEAIVL 
               
               
                   
                   
                   
                   
                 TVPGSERSYDLTGLKPGTEYVVFIGGVKGGH 
               
               
                   
                   
                   
                   
                 NSTPLSAIFTTGGGGSGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FWITYEEKFYRGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 920 
                 PRT 
                 Human 
                 CR- 
                 EQKLISEEDLEVQLVETGGGLVKPGGSLRLSC 
               
               
                   
                   
                   
                 5133HC146 
                 SASRFSFRDYYMTWIRQAPGKGPEWVSHISG 
               
               
                   
                   
                   
                   
                 SGSTIYYADSVRGRFTISRDNAKSSLYLQMDS 
               
               
                   
                   
                   
                   
                 LQADDTAVYYCARGGRATSYYWVHWGPGT 
               
               
                   
                   
                   
                   
                 LVTVSSASTKGPSVFPLAPSSKSTSGGTAALG 
               
               
                   
                   
                   
                   
                 CLVKDYFPEPVTVSWNSGALTSGVHTFPAVL 
               
               
                   
                   
                   
                   
                 QSSGLYSLSSVVTVPSSSLGTQTYICNVNHKP 
               
               
                   
                   
                   
                   
                 SNTKVDKKVEPKSCDKTHTCPPCPAPPVAGP 
               
               
                   
                   
                   
                   
                 DVFLFPPKPKDTLMISRTPEVTCVVVDVSHED 
               
               
                   
                   
                   
                   
                 PEVKFNWYVDGVEVHNAKTKPREEQYNSTY 
               
               
                   
                   
                   
                   
                 RVVSVLTVLHQDWLNGKEYKCKVSNAALPA 
               
               
                   
                   
                   
                   
                 PIAKTISKAKGQPREPQVYTLPPSRDELTKNQ 
               
               
                   
                   
                   
                   
                 VSLTCLVKGFYPSDIAVEWESNGQPENNYKT 
               
               
                   
                   
                   
                   
                 TPPVLDSDGSFFLYSKLTVDKSRWQQGNVFS 
               
               
                   
                   
                   
                   
                 CSVMHEALHNRFTQKSLSLSPGKGGGGSGG 
               
               
                   
                   
                   
                   
                 GGSGGGGSGGGGSMLPAPKNLVVSRVTEDS 
               
               
                   
                   
                   
                   
                 ARLSWTAPDAAFDSFHIEYAEPWVWGEAIVL 
               
               
                   
                   
                   
                   
                 TVPGSERSYDLTGLKPGTEYVVFIGGVKGGH 
               
               
                   
                   
                   
                   
                 NSTPLSAIFTTGGGGSGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FWITYEEKFYRGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYKVWIVGVKGGQGSWPLSAIFTTDYKD 
               
               
                   
                   
                   
                   
                 DDDK 
               
               
                   
               
               
                 921 
                 PRT 
                 Human 
                 CSD7HC151 
                 QVQLQESGPGLVKPSETLSLTCTVSGGSIRSSS 
               
               
                   
                   
                   
                   
                 YYWGWFRQTPGKGLEWLGNVFFSGSAYYNP 
               
               
                   
                   
                   
                   
                 SLKNRVTISIDTSENQSSLKLTSVTAADTAVY 
               
               
                   
                   
                   
                   
                 YCARPQAYSHDSSGHSPFDLWGRGTLVTVSS 
               
               
                   
                   
                   
                   
                 ASTKGPSVFPLAPSSKSTSGGTAALGCLVKD 
               
               
                   
                   
                   
                   
                 YFPEPVTVSWNSGALTSGVHTFPAVLQSSGL 
               
               
                   
                   
                   
                   
                 YSLSSVVTVPSSSLGTQTYICNVNHKPSNTKV 
               
               
                   
                   
                   
                   
                 DKKVEPKSCDKTHTCPPCPAPPVAGPDVFLFP 
               
               
                   
                   
                   
                   
                 PKPKDTLMISRTPEVTCVVVDVSHEDPEVKF 
               
               
                   
                   
                   
                   
                 NWYVDGVEVHNAKTKPREEQYNSTYRVVS 
               
               
                   
                   
                   
                   
                 VLTVLHQDWLNGKEYKCKVSNAALPAPIAK 
               
               
                   
                   
                   
                   
                 TISKAKGQPREPQVYTLPPSRDELTKNQVSLT 
               
               
                   
                   
                   
                   
                 CLVKGFYPSDIAVEWESNGQPENNYKTTPPV 
               
               
                   
                   
                   
                   
                 LDSDGSFFLYSKLTVDKSRWQQGNVFSCSV 
               
               
                   
                   
                   
                   
                 MHEALHNRFTQKSLSLSPGKGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFHIEYAEPWVWGEAIVLTVP 
               
               
                   
                   
                   
                   
                 GSERSYDLTGLKPGTEYVVFIGGVKGGHNST 
               
               
                   
                   
                   
                   
                 PLSAIFTTGGGGSGGGGSGGGGSGGGGSMLP 
               
               
                   
                   
                   
                   
                 APKNLVVSRVTEDSARLSWTAPDAAFDSFWI 
               
               
                   
                   
                   
                   
                 TYEEKFYRGEAIVLTVPGSERSYDLTGLKPGT 
               
               
                   
                   
                   
                   
                 EYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 922 
                 PRT 
                 Human 
                 CSD7HC152 
                 QVQLQESGPGLVKPSETLSLTCTVSGGSIRSSS 
               
               
                   
                   
                   
                   
                 YYWGWFRQTPGKGLEWLGNVFFSGSAYYNP 
               
               
                   
                   
                   
                   
                 SLKNRVTISIDTSENQSSLKLTSVTAADTAVY 
               
               
                   
                   
                   
                   
                 YCARPQAYSHDSSGHSPFDLWGRGTLVTVSS 
               
               
                   
                   
                   
                   
                 ASTKGPSVFPLAPSSKSTSGGTAALGCLVKD 
               
               
                   
                   
                   
                   
                 YFPEPVTVSWNSGALTSGVHTFPAVLQSSGL 
               
               
                   
                   
                   
                   
                 YSLSSVVTVPSSSLGTQTYICNVNHKPSNTKV 
               
               
                   
                   
                   
                   
                 DKKVEPKSCDKTHTCPPCPAPPVAGPDVFLFP 
               
               
                   
                   
                   
                   
                 PKPKDTLMISRTPEVTCVVVDVSHEDPEVKF 
               
               
                   
                   
                   
                   
                 NWYVDGVEVHNAKTKPREEQYNSTYRVVS 
               
               
                   
                   
                   
                   
                 VLTVLHQDWLNGKEYKCKVSNAALPAPIAK 
               
               
                   
                   
                   
                   
                 TISKAKGQPREPQVYTLPPSRDELTKNQVSLT 
               
               
                   
                   
                   
                   
                 CLVKGFYPSDIAVEWESNGQPENNYKTTPPV 
               
               
                   
                   
                   
                   
                 LDSDGSFFLYSKLTVDKSRWQQGNVFSCSV 
               
               
                   
                   
                   
                   
                 MHEALHNHYTQKSLSLSPGKGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFHIEYAEPWVWGEAIVLTVP 
               
               
                   
                   
                   
                   
                 GSERSYDLTGLKPGTEYVVFIGGVKGGHNST 
               
               
                   
                   
                   
                   
                 PLSAIFTTGGGGSGGGGSGGGGSGGGGSMLP 
               
               
                   
                   
                   
                   
                 APKNLVVSRVTEDSARLSWTAPDAAFDSFWI 
               
               
                   
                   
                   
                   
                 TYEEKFYRGEAIVLTVPGSERSYDLTGLKPGT 
               
               
                   
                   
                   
                   
                 EYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 923 
                 PRT 
                 Human 
                 CR- 
                 QVQLQESGGGVVQPGRSLRLSCAASGFTFSS 
               
               
                   
                   
                   
                 6526HC153 
                 YGMHWVRQAPGKGLEWVAVISYDGSNKYY 
               
               
                   
                   
                   
                   
                 ADSVKGRFTISRDNSKNTLYLQMNSLRAEDT 
               
               
                   
                   
                   
                   
                 AVYYCAKNGANAFDIWGQGTMVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSS 
               
               
                   
                   
                   
                   
                 VVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 
               
               
                   
                   
                   
                   
                 EPKSCDKTHTCPPCPAPPVAGPDVFLFPPKPK 
               
               
                   
                   
                   
                   
                 DTLMISRTPEVTCVVVDVSHEDPEVKFNWYV 
               
               
                   
                   
                   
                   
                 DGVEVHNAKTKPREEQYNSTYRVVSVLTVL 
               
               
                   
                   
                   
                   
                 HQDWLNGKEYKCKVSNAALPAPIAKTISKAK 
               
               
                   
                   
                   
                   
                 GQPREPQVYTLPPSRDELTKNQVSLTCLVKG 
               
               
                   
                   
                   
                   
                 FYPSDIAVEWESNGQPENNYKTTPPVLDSDG 
               
               
                   
                   
                   
                   
                 SFFLYSKLTVDKSRWQQGNVFSCSVMHEAL 
               
               
                   
                   
                   
                   
                 HNRFTQKSLSLSPGKGGGGSGGGGSGGGGSG 
               
               
                   
                   
                   
                   
                 GGGSMLPAPKNLVVSRVTEDSARLSWTAPD 
               
               
                   
                   
                   
                   
                 AAFDSFHIEYAEPWVWGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYVVFIGGVKGGHNSTPLSAIFT 
               
               
                   
                   
                   
                   
                 TGGGGSGGGGSGGGGSGGGGSMLPAPKNLV 
               
               
                   
                   
                   
                   
                 VSRVTEDSARLSWTAPDAAFDSFWITYEEKF 
               
               
                   
                   
                   
                   
                 YRGEAIVLTVPGSERSYDLTGLKPGTEYKVW 
               
               
                   
                   
                   
                   
                 IVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 924 
                 PRT 
                 Human 
                 CR- 
                 QVQLQESGGGVVQPGRSLRLSCAASGFTFSS 
               
               
                   
                   
                   
                 6526HC154 
                 YGMHWVRQAPGKGLEWVAVISYDGSNKYY 
               
               
                   
                   
                   
                   
                 ADSVKGRFTISRDNSKNTLYLQMNSLRAEDT 
               
               
                   
                   
                   
                   
                 AVYYCAKNGANAFDIWGQGTMVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSS 
               
               
                   
                   
                   
                   
                 VVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 
               
               
                   
                   
                   
                   
                 EPKSCDKTHTCPPCPAPPVAGPDVFLFPPKPK 
               
               
                   
                   
                   
                   
                 DTLMISRTPEVTCVVVDVSHEDPEVKFNWYV 
               
               
                   
                   
                   
                   
                 DGVEVHNAKTKPREEQYNSTYRVVSVLTVL 
               
               
                   
                   
                   
                   
                 HQDWLNGKEYKCKVSNAALPAPIAKTISKAK 
               
               
                   
                   
                   
                   
                 GQPREPQVYTLPPSRDELTKNQVSLTCLVKG 
               
               
                   
                   
                   
                   
                 FYPSDIAVEWESNGQPENNYKTTPPVLDSDG 
               
               
                   
                   
                   
                   
                 SFFLYSKLTVDKSRWQQGNVFSCSVMHEAL 
               
               
                   
                   
                   
                   
                 HNHYTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSMLPAPKNL 
               
               
                   
                   
                   
                   
                 VVSRVTEDSARLSWTAPDAAFDSFWITYEEK 
               
               
                   
                   
                   
                   
                 FYRGEAIVLTVPGSERSYDLTGLKPGTEYKV 
               
               
                   
                   
                   
                   
                 WIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 925 
                 PRT 
                 Human 
                 PagibaximabHC155 
                 EVMLVESGGGLVQPKGSLKLSCAASGFTFNN 
               
               
                   
                   
                   
                   
                 YAMNWVRQAPGKGLEWVARIRSKSNNYAT 
               
               
                   
                   
                   
                   
                 FYADSVKDRFTISRDDSQSMLYLQMNNLKTE 
               
               
                   
                   
                   
                   
                 DTAMYYCVRRGASGIDYAMDYWGQGTSLT 
               
               
                   
                   
                   
                   
                 VSSASTKGPSVFPLAPSSKSTSGGTAALGCLV 
               
               
                   
                   
                   
                   
                 KDYFPEPVTVSWNSGALTSGVHTFPAVLQSS 
               
               
                   
                   
                   
                   
                 GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT 
               
               
                   
                   
                   
                   
                 KVDKKVEPKSCDKTHTCPPCPAPPVAGPDVF 
               
               
                   
                   
                   
                   
                 LFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV 
               
               
                   
                   
                   
                   
                 KFNWYVDGVEVHNAKTKPREEQYNSTYRV 
               
               
                   
                   
                   
                   
                 VSVLTVLHQDWLNGKEYKCKVSNAALPAPI 
               
               
                   
                   
                   
                   
                 AKTISKAKGQPREPQVYTLPPSRDELTKNQVS 
               
               
                   
                   
                   
                   
                 LTCLVKGFYPSDIAVEWESNGQPENNYKTTP 
               
               
                   
                   
                   
                   
                 PVLDSDGSFFLYSKLTVDKSRWQQGNVFSCS 
               
               
                   
                   
                   
                   
                 VMHEALHNRFTQKSLSLSPGKGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSMLPAPKNLVVSRVTEDSAR 
               
               
                   
                   
                   
                   
                 LSWTAPDAAFDSFHIEYAEPWVWGEAIVLTV 
               
               
                   
                   
                   
                   
                 PGSERSYDLTGLKPGTEYVVFIGGVKGGHNS 
               
               
                   
                   
                   
                   
                 TPLSAIFTTGGGGSGGGGSGGGGSGGGGSML 
               
               
                   
                   
                   
                   
                 PAPKNLVVSRVTEDSARLSWTAPDAAFDSFW 
               
               
                   
                   
                   
                   
                 ITYEEKFYRGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                   
                 TEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 926 
                 PRT 
                 Human 
                 PagibaximabHC156 
                 EVMLVESGGGLVQPKGSLKLSCAASGFTFNN 
               
               
                   
                   
                   
                   
                 YAMNWVRQAPGKGLEWVARIRSKSNNYAT 
               
               
                   
                   
                   
                   
                 FYADSVKDRFTISRDDSQSMLYLQMNNLKTE 
               
               
                   
                   
                   
                   
                 DTAMYYCVRRGASGIDYAMDYWGQGTSLT 
               
               
                   
                   
                   
                   
                 VSSASTKGPSVFPLAPSSKSTSGGTAALGCLV 
               
               
                   
                   
                   
                   
                 KDYFPEPVTVSWNSGALTSGVHTFPAVLQSS 
               
               
                   
                   
                   
                   
                 GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT 
               
               
                   
                   
                   
                   
                 KVDKKVEPKSCDKTHTCPPCPAPPVAGPDVF 
               
               
                   
                   
                   
                   
                 LFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV 
               
               
                   
                   
                   
                   
                 KFNWYVDGVEVHNAKTKPREEQYNSTYRV 
               
               
                   
                   
                   
                   
                 VSVLTVLHQDWLNGKEYKCKVSNAALPAPI 
               
               
                   
                   
                   
                   
                 AKTISKAKGQPREPQVYTLPPSRDELTKNQVS 
               
               
                   
                   
                   
                   
                 LTCLVKGFYPSDIAVEWESNGQPENNYKTTP 
               
               
                   
                   
                   
                   
                 PVLDSDGSFFLYSKLTVDKSRWQQGNVFSCS 
               
               
                   
                   
                   
                   
                 VMHEALHNHYTQKSLSLSPGKGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSMLPAPKNLVVSRVTEDSAR 
               
               
                   
                   
                   
                   
                 LSWTAPDAAFDSFHIEYAEPWVWGEAIVLTV 
               
               
                   
                   
                   
                   
                 PGSERSYDLTGLKPGTEYVVFIGGVKGGHNS 
               
               
                   
                   
                   
                   
                 TPLSAIFTTGGGGSGGGGSGGGGSGGGGSML 
               
               
                   
                   
                   
                   
                 PAPKNLVVSRVTEDSARLSWTAPDAAFDSFW 
               
               
                   
                   
                   
                   
                 ITYEEKFYRGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                   
                 TEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 927 
                 PRT 
                 Human 
                 RSVHC157 
                 QITLKESGPTLVKPTQTLTLTCTFSGFSLSTSG 
               
               
                   
                   
                   
                   
                 MGVSWIRQPPGKALEWLAHIYWDDDKRYNP 
               
               
                   
                   
                   
                   
                 SLKSRLTITKDTSKNQVVLTMTNMDPVDTAT 
               
               
                   
                   
                   
                   
                 YYCARLYGFTYGFAYWGQGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSS 
               
               
                   
                   
                   
                   
                 VVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 
               
               
                   
                   
                   
                   
                 EPKSCDKTHTCPPCPAPPVAGPDVFLFPPKPK 
               
               
                   
                   
                   
                   
                 DTLMISRTPEVTCVVVDVSHEDPEVKFNWYV 
               
               
                   
                   
                   
                   
                 DGVEVHNAKTKPREEQYNSTYRVVSVLTVL 
               
               
                   
                   
                   
                   
                 HQDWLNGKEYKCKVSNAALPAPIAKTISKAK 
               
               
                   
                   
                   
                   
                 GQPREPQVYTLPPSRDELTKNQVSLTCLVKG 
               
               
                   
                   
                   
                   
                 FYPSDIAVEWESNGQPENNYKTTPPVLDSDG 
               
               
                   
                   
                   
                   
                 SFFLYSKLTVDKSRWQQGNVFSCSVMHEAL 
               
               
                   
                   
                   
                   
                 HNRFTQKSLSLSPGKGGGGSGGGGSGGGGSG 
               
               
                   
                   
                   
                   
                 GGGSMLPAPKNLVVSRVTEDSARLSWTAPD 
               
               
                   
                   
                   
                   
                 AAFDSFHIEYAEPWVWGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYVVFIGGVKGGHNSTPLSAIFT 
               
               
                   
                   
                   
                   
                 TGGGGSGGGGSGGGGSGGGGSMLPAPKNLV 
               
               
                   
                   
                   
                   
                 VSRVTEDSARLSWTAPDAAFDSFWITYEEKF 
               
               
                   
                   
                   
                   
                 YRGEAIVLTVPGSERSYDLTGLKPGTEYKVW 
               
               
                   
                   
                   
                   
                 IVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 928 
                 PRT 
                 Human 
                 RSVHC158 
                 QITLKESGPTLVKPTQTLTLTCTFSGFSLSTSG 
               
               
                   
                   
                   
                   
                 MGVSWIRQPPGKALEWLAHIYWDDDKRYNP 
               
               
                   
                   
                   
                   
                 SLKSRLTITKDTSKNQVVLTMTNMDPVDTAT 
               
               
                   
                   
                   
                   
                 YYCARLYGFTYGFAYWGQGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSS 
               
               
                   
                   
                   
                   
                 VVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 
               
               
                   
                   
                   
                   
                 EPKSCDKTHTCPPCPAPPVAGPDVFLFPPKPK 
               
               
                   
                   
                   
                   
                 DTLMISRTPEVTCVVVDVSHEDPEVKFNWYV 
               
               
                   
                   
                   
                   
                 DGVEVHNAKTKPREEQYNSTYRVVSVLTVL 
               
               
                   
                   
                   
                   
                 HQDWLNGKEYKCKVSNAALPAPIAKTISKAK 
               
               
                   
                   
                   
                   
                 GQPREPQVYTLPPSRDELTKNQVSLTCLVKG 
               
               
                   
                   
                   
                   
                 FYPSDIAVEWESNGQPENNYKTTPPVLDSDG 
               
               
                   
                   
                   
                   
                 SFFLYSKLTVDKSRWQQGNVFSCSVMHEAL 
               
               
                   
                   
                   
                   
                 HNHYTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSMLPAPKNL 
               
               
                   
                   
                   
                   
                 VVSRVTEDSARLSWTAPDAAFDSFWITYEEK 
               
               
                   
                   
                   
                   
                 FYRGEAIVLTVPGSERSYDLTGLKPGTEYKV 
               
               
                   
                   
                   
                   
                 WIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 929 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGVAVQPGRSLRLSCAASGFSFRD 
               
               
                   
                   
                   
                 6171HC159 
                 YGMHWVRQAAGKGLEWVAFIWPHGVNRFY 
               
               
                   
                   
                   
                   
                 ADSMEGRFTISRDDSKNMLYLEMNNLRTEDT 
               
               
                   
                   
                   
                   
                 ALYYCTRDQDYVPRKYFDLWGRGTLVTVSS 
               
               
                   
                   
                   
                   
                 ASTKGPSVFPLAPSSKSTSGGTAALGCLVKD 
               
               
                   
                   
                   
                   
                 YFPEPVTVSWNSGALTSGVHTFPAVLQSSGL 
               
               
                   
                   
                   
                   
                 YSLSSVVTVPSSSLGTQTYICNVNHKPSNTKV 
               
               
                   
                   
                   
                   
                 DKKVEPKSCDKTHTCPPCPAPPVAGPDVFLFP 
               
               
                   
                   
                   
                   
                 PKPKDTLMISRTPEVTCVVVDVSHEDPEVKF 
               
               
                   
                   
                   
                   
                 NWYVDGVEVHNAKTKPREEQYNSTYRVVS 
               
               
                   
                   
                   
                   
                 VLTVLHQDWLNGKEYKCKVSNAALPAPIAK 
               
               
                   
                   
                   
                   
                 TISKAKGQPREPQVYTLPPSRDELTKNQVSLT 
               
               
                   
                   
                   
                   
                 CLVKGFYPSDIAVEWESNGQPENNYKTTPPV 
               
               
                   
                   
                   
                   
                 LDSDGSFFLYSKLTVDKSRWQQGNVFSCSV 
               
               
                   
                   
                   
                   
                 MHEALHNRFTQKSLSLSPGKGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFHIEYAEPWVWGEAIVLTVP 
               
               
                   
                   
                   
                   
                 GSERSYDLTGLKPGTEYVVFIGGVKGGHNST 
               
               
                   
                   
                   
                   
                 PLSAIFTTGGGGSGGGGSGGGGSGGGGSMLP 
               
               
                   
                   
                   
                   
                 APKNLVVSRVTEDSARLSWTAPDAAFDSFWI 
               
               
                   
                   
                   
                   
                 TYEEKFYRGEAIVLTVPGSERSYDLTGLKPGT 
               
               
                   
                   
                   
                   
                 EYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 930 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGVAVQPGRSLRLSCAASGFSFRD 
               
               
                   
                   
                   
                 6171HC160 
                 YGMHWVRQAAGKGLEWVAFIWPHGVNRFY 
               
               
                   
                   
                   
                   
                 ADSMEGRFTISRDDSKNMLYLEMNNLRTEDT 
               
               
                   
                   
                   
                   
                 ALYYCTRDQDYVPRKYFDLWGRGTLVTVSS 
               
               
                   
                   
                   
                   
                 ASTKGPSVFPLAPSSKSTSGGTAALGCLVKD 
               
               
                   
                   
                   
                   
                 YFPEPVTVSWNSGALTSGVHTFPAVLQSSGL 
               
               
                   
                   
                   
                   
                 YSLSSVVTVPSSSLGTQTYICNVNHKPSNTKV 
               
               
                   
                   
                   
                   
                 DKKVEPKSCDKTHTCPPCPAPPVAGPDVFLFP 
               
               
                   
                   
                   
                   
                 PKPKDTLMISRTPEVTCVVVDVSHEDPEVKF 
               
               
                   
                   
                   
                   
                 NWYVDGVEVHNAKTKPREEQYNSTYRVVS 
               
               
                   
                   
                   
                   
                 VLTVLHQDWLNGKEYKCKVSNAALPAPIAK 
               
               
                   
                   
                   
                   
                 TISKAKGQPREPQVYTLPPSRDELTKNQVSLT 
               
               
                   
                   
                   
                   
                 CLVKGFYPSDIAVEWESNGQPENNYKTTPPV 
               
               
                   
                   
                   
                   
                 LDSDGSFFLYSKLTVDKSRWQQGNVFSCSV 
               
               
                   
                   
                   
                   
                 MHEALHNHYTQKSLSLSPGKGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFHIEYAEPWVWGEAIVLTVP 
               
               
                   
                   
                   
                   
                 GSERSYDLTGLKPGTEYVVFIGGVKGGHNST 
               
               
                   
                   
                   
                   
                 PLSAIFTTGGGGSGGGGSGGGGSGGGGSMLP 
               
               
                   
                   
                   
                   
                 APKNLVVSRVTEDSARLSWTAPDAAFDSFWI 
               
               
                   
                   
                   
                   
                 TYEEKFYRGEAIVLTVPGSERSYDLTGLKPGT 
               
               
                   
                   
                   
                   
                 EYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 931 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC161 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFHIEYAEPWVWGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYVVFIGGVKG 
               
               
                   
                   
                   
                   
                 GHNSTPLSAIFTTMLPAPKNLVVSRVTEDSAR 
               
               
                   
                   
                   
                   
                 LSWTAPDAAFDSFWITYEEKFYRGEAIVLTVP 
               
               
                   
                   
                   
                   
                 GSERSYDLTGLKPGTEYKVWIVGVKGGQGS 
               
               
                   
                   
                   
                   
                 WPLSAIFTT 
               
               
                   
               
               
                 932 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC162 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFHIEYAEPWVWGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYVVFIGGVKG 
               
               
                   
                   
                   
                   
                 GHNSTPLSAIFTTGGGGSMLPAPKNLVVSRV 
               
               
                   
                   
                   
                   
                 TEDSARLSWTAPDAAFDSFWITYEEKFYRGE 
               
               
                   
                   
                   
                   
                 AIVLTVPGSERSYDLTGLKPGTEYKVWIVGV 
               
               
                   
                   
                   
                   
                 KGGQGSWPLSAIFTT 
               
               
                   
               
               
                 933 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC163 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFHIEYAEPWVWGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYVVFIGGVKG 
               
               
                   
                   
                   
                   
                 GHNSTPLSAIFTTGGGGSGGGGSMLPAPKNL 
               
               
                   
                   
                   
                   
                 VVSRVTEDSARLSWTAPDAAFDSFWITYEEK 
               
               
                   
                   
                   
                   
                 FYRGEAIVLTVPGSERSYDLTGLKPGTEYKV 
               
               
                   
                   
                   
                   
                 WIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 934 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC164 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFHIEYAEPWVWGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYVVFIGGVKG 
               
               
                   
                   
                   
                   
                 GHNSTPLSAIFTTGGGGSGGGGSGGGGSMLP 
               
               
                   
                   
                   
                   
                 APKNLVVSRVTEDSARLSWTAPDAAFDSFWI 
               
               
                   
                   
                   
                   
                 TYEEKFYRGEAIVLTVPGSERSYDLTGLKPGT 
               
               
                   
                   
                   
                   
                 EYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 935 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC165 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFHIEYAEPWVWGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYVVFIGGVKG 
               
               
                   
                   
                   
                   
                 GHNSTPLSAIFTTGGGGSGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSMLPAPKNLVVSRVTEDSARLSWTAPDAAF 
               
               
                   
                   
                   
                   
                 DSFWITYEEKFYRGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                   
                 LKPGTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 936 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC166 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSMLPAPKNLVV 
               
               
                   
                   
                   
                   
                 SRVTEDSARLSWTAPDAAFDSFHIEYAEPWV 
               
               
                   
                   
                   
                   
                 WGEAIVLTVPGSERSYDLTGLKPGTEYVVFIG 
               
               
                   
                   
                   
                   
                 GVKGGHNSTPLSAIFTTMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFWITYEEKFYRGEA 
               
               
                   
                   
                   
                   
                 IVLTVPGSERSYDLTGLKPGTEYKVWIVGVK 
               
               
                   
                   
                   
                   
                 GGQGSWPLSAIFTT 
               
               
                   
               
               
                 937 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC167 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSMLPAPKNLVV 
               
               
                   
                   
                   
                   
                 SRVTEDSARLSWTAPDAAFDSFHIEYAEPWV 
               
               
                   
                   
                   
                   
                 WGEAIVLTVPGSERSYDLTGLKPGTEYVVFIG 
               
               
                   
                   
                   
                   
                 GVKGGHNSTPLSAIFTTGGGGSMLPAPKNLV 
               
               
                   
                   
                   
                   
                 VSRVTEDSARLSWTAPDAAFDSFWITYEEKF 
               
               
                   
                   
                   
                   
                 YRGEAIVLTVPGSERSYDLTGLKPGTEYKVW 
               
               
                   
                   
                   
                   
                 IVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 938 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC168 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSMLPAPKNLVV 
               
               
                   
                   
                   
                   
                 SRVTEDSARLSWTAPDAAFDSFHIEYAEPWV 
               
               
                   
                   
                   
                   
                 WGEAIVLTVPGSERSYDLTGLKPGTEYVVFIG 
               
               
                   
                   
                   
                   
                 GVKGGHNSTPLSAIFTTGGGGSGGGGSMLPA 
               
               
                   
                   
                   
                   
                 PKNLVVSRVTEDSARLSWTAPDAAFDSFWIT 
               
               
                   
                   
                   
                   
                 YEEKFYRGEAIVLTVPGSERSYDLTGLKPGTE 
               
               
                   
                   
                   
                   
                 YKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 939 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC169 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSMLPAPKNLVV 
               
               
                   
                   
                   
                   
                 SRVTEDSARLSWTAPDAAFDSFHIEYAEPWV 
               
               
                   
                   
                   
                   
                 WGEAIVLTVPGSERSYDLTGLKPGTEYVVFIG 
               
               
                   
                   
                   
                   
                 GVKGGHNSTPLSAIFTTGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SMLPAPKNLVVSRVTEDSARLSWTAPDAAFD 
               
               
                   
                   
                   
                   
                 SFWITYEEKFYRGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 940 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC170 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSMLPAPKNLVV 
               
               
                   
                   
                   
                   
                 SRVTEDSARLSWTAPDAAFDSFHIEYAEPWV 
               
               
                   
                   
                   
                   
                 WGEAIVLTVPGSERSYDLTGLKPGTEYVVFIG 
               
               
                   
                   
                   
                   
                 GVKGGHNSTPLSAIFTTGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFWITYEEKFYRGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYKVWIVGVKGGQGSWPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 941 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC171 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSMLPAP 
               
               
                   
                   
                   
                   
                 KNLVVSRVTEDSARLSWTAPDAAFDSFHIEY 
               
               
                   
                   
                   
                   
                 AEPWVWGEAIVLTVPGSERSYDLTGLKPGTE 
               
               
                   
                   
                   
                   
                 YVVFIGGVKGGHNSTPLSAIFTTMLPAPKNLV 
               
               
                   
                   
                   
                   
                 VSRVTEDSARLSWTAPDAAFDSFWITYEEKF 
               
               
                   
                   
                   
                   
                 YRGEAIVLTVPGSERSYDLTGLKPGTEYKVW 
               
               
                   
                   
                   
                   
                 IVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 942 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC172 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSMLPAP 
               
               
                   
                   
                   
                   
                 KNLVVSRVTEDSARLSWTAPDAAFDSFHIEY 
               
               
                   
                   
                   
                   
                 AEPWVWGEAIVLTVPGSERSYDLTGLKPGTE 
               
               
                   
                   
                   
                   
                 YVVFIGGVKGGHNSTPLSAIFTTGGGGSMLP 
               
               
                   
                   
                   
                   
                 APKNLVVSRVTEDSARLSWTAPDAAFDSFWI 
               
               
                   
                   
                   
                   
                 TYEEKFYRGEAIVLTVPGSERSYDLTGLKPGT 
               
               
                   
                   
                   
                   
                 EYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 943 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC173 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSMLPAP 
               
               
                   
                   
                   
                   
                 KNLVVSRVTEDSARLSWTAPDAAFDSFHIEY 
               
               
                   
                   
                   
                   
                 AEPWVWGEAIVLTVPGSERSYDLTGLKPGTE 
               
               
                   
                   
                   
                   
                 YVVFIGGVKGGHNSTPLSAIFTTGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSMLPAPKNLVVSRVTEDSARLSWTAPDAAF 
               
               
                   
                   
                   
                   
                 DSFWITYEEKFYRGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                   
                 LKPGTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 944 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC174 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSMLPAP 
               
               
                   
                   
                   
                   
                 KNLVVSRVTEDSARLSWTAPDAAFDSFHIEY 
               
               
                   
                   
                   
                   
                 AEPWVWGEAIVLTVPGSERSYDLTGLKPGTE 
               
               
                   
                   
                   
                   
                 YVVFIGGVKGGHNSTPLSAIFTTGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFWITYEEKFYRGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYKVWIVGVKGGQGSWPLS 
               
               
                   
                   
                   
                   
                 AIFTT 
               
               
                   
               
               
                 945 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC175 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSMLPAP 
               
               
                   
                   
                   
                   
                 KNLVVSRVTEDSARLSWTAPDAAFDSFHIEY 
               
               
                   
                   
                   
                   
                 AEPWVWGEAIVLTVPGSERSYDLTGLKPGTE 
               
               
                   
                   
                   
                   
                 YVVFIGGVKGGHNSTPLSAIFTTGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSGGGGSMLPAPKNLVVSRVTEDSA 
               
               
                   
                   
                   
                   
                 RLSWTAPDAAFDSFWITYEEKFYRGEAIVLT 
               
               
                   
                   
                   
                   
                 VPGSERSYDLTGLKPGTEYKVWIVGVKGGQ 
               
               
                   
                   
                   
                   
                 GSWPLSAIFTT 
               
               
                   
               
               
                 946 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC176 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYAEPWVWGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYVVFIGGVKGGHNSTPLSAIFTTMLPA 
               
               
                   
                   
                   
                   
                 PKNLVVSRVTEDSARLSWTAPDAAFDSFWIT 
               
               
                   
                   
                   
                   
                 YEEKFYRGEAIVLTVPGSERSYDLTGLKPGTE 
               
               
                   
                   
                   
                   
                 YKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 947 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC177 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYAEPWVWGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYVVFIGGVKGGHNSTPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SMLPAPKNLVVSRVTEDSARLSWTAPDAAFD 
               
               
                   
                   
                   
                   
                 SFWITYEEKFYRGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 948 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC178 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYAEPWVWGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYVVFIGGVKGGHNSTPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFWITYEEKFYRGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYKVWIVGVKGGQGSWPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 949 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC179 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYAEPWVWGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYVVFIGGVKGGHNSTPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSMLPAPKNLVVSRVTEDSAR 
               
               
                   
                   
                   
                   
                 LSWTAPDAAFDSFWITYEEKFYRGEAIVLTVP 
               
               
                   
                   
                   
                   
                 GSERSYDLTGLKPGTEYKVWIVGVKGGQGS 
               
               
                   
                   
                   
                   
                 WPLSAIFTT 
               
               
                   
               
               
                 950 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC180 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYAEPWVWGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYVVFIGGVKGGHNSTPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFWITYEEKFYRGEA 
               
               
                   
                   
                   
                   
                 IVLTVPGSERSYDLTGLKPGTEYKVWIVGVK 
               
               
                   
                   
                   
                   
                 GGQGSWPLSAIFTT 
               
               
                   
               
               
                 951 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC181 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TTMLPAPKNLVVSRVTEDSARLSWTAPDAAF 
               
               
                   
                   
                   
                   
                 DSFWITYEEKFYRGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                   
                 LKPGTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 952 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC182 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFWITYEEKFYRGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYKVWIVGVKGGQGSWPLS 
               
               
                   
                   
                   
                   
                 AIFTT 
               
               
                   
               
               
                 953 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC183 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSMLPAPKNLVVSRVTEDSA 
               
               
                   
                   
                   
                   
                 RLSWTAPDAAFDSFWITYEEKFYRGEAIVLT 
               
               
                   
                   
                   
                   
                 VPGSERSYDLTGLKPGTEYKVWIVGVKGGQ 
               
               
                   
                   
                   
                   
                 GSWPLSAIFTT 
               
               
                   
               
               
                 954 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC184 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSMLPAPKNLVVSRV 
               
               
                   
                   
                   
                   
                 TEDSARLSWTAPDAAFDSFWITYEEKFYRGE 
               
               
                   
                   
                   
                   
                 AIVLTVPGSERSYDLTGLKPGTEYKVWIVGV 
               
               
                   
                   
                   
                   
                 KGGQGSWPLSAIFTT 
               
               
                   
               
               
                 955 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC185 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGGGGGSGGGGSGGGGSG 
               
               
                   
                   
                   
                   
                 GGGSMLPAPKNLVVSRVTEDSARLSWTAPD 
               
               
                   
                   
                   
                   
                 AAFDSFPIVYQEWQFYGEAIVLTVPGSERSYD 
               
               
                   
                   
                   
                   
                 LTGLKPGTEYLVDIYGVKGGSWSYPLSAIFTT 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSGGGGSMLPAPKNLVV 
               
               
                   
                   
                   
                   
                 SRVTEDSARLSWTAPDAAFDSFWITYEEKFY 
               
               
                   
                   
                   
                   
                 RGEAIVLTVPGSERSYDLTGLKPGTEYKVWI 
               
               
                   
                   
                   
                   
                 VGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 956 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC186 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNHYTQKSLSLSPGGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFPIVYQEWQFYGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYLVDIYGVKGGSWSYPLSAIFT 
               
               
                   
                   
                   
                   
                 TGGGGSGGGGSGGGGSGGGGSMLPAPKNLV 
               
               
                   
                   
                   
                   
                 VSRVTEDSARLSWTAPDAAFDSFWITYEEKF 
               
               
                   
                   
                   
                   
                 YRGEAIVLTVPGSERSYDLTGLKPGTEYKVW 
               
               
                   
                   
                   
                   
                 IVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 957 
                 PRT 
                 Human 
                 RSVHC187 
                 QITLKESGPTLVKPTQTLTLTCTFSGFSLSTSG 
               
               
                   
                   
                   
                   
                 MGVSWIRQPPGKALEWLAHIYWDDDKRYNP 
               
               
                   
                   
                   
                   
                 SLKSRLTITKDTSKNQVVLTMTNMDPVDTAT 
               
               
                   
                   
                   
                   
                 YYCARLYGFTYGFAYWGQGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSS 
               
               
                   
                   
                   
                   
                 VVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 
               
               
                   
                   
                   
                   
                 EPKSCDKTHTCPPCPAPPVAGPDVFLFPPKPK 
               
               
                   
                   
                   
                   
                 DTLMISRTPEVTCVVVDVSHEDPEVKFNWYV 
               
               
                   
                   
                   
                   
                 DGVEVHNAKTKPREEQYNSTYRVVSVLTVL 
               
               
                   
                   
                   
                   
                 HQDWLNGKEYKCKVSNAALPAPIAKTISKAK 
               
               
                   
                   
                   
                   
                 GQPREPQVYTLPPSRDELTKNQVSLTCLVKG 
               
               
                   
                   
                   
                   
                 FYPSDIAVEWESNGQPENNYKTTPPVLDSDG 
               
               
                   
                   
                   
                   
                 SFFLYSKLTVDKSRWQQGNVFSCSVMHEAL 
               
               
                   
                   
                   
                   
                 HNHYTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSLPAPKNLVVSRVTEDSARLSWTAPDA 
               
               
                   
                   
                   
                   
                 AFDSFLIQYQESEKVGEAIVLTVPGSERSYDL 
               
               
                   
                   
                   
                   
                 TGLKPGTEYTVSIYGVKGGHRSNPLSAIFTTG 
               
               
                   
                   
                   
                   
                 GGGSGGGGSGGGGSGGGGSLPAPKNLVVSR 
               
               
                   
                   
                   
                   
                 VTEDSARLSWTAPDAAFDSFLIQYQESEKVG 
               
               
                   
                   
                   
                   
                 EAIVLTVPGSERSYDLTGLKPGTEYTVSIYGV 
               
               
                   
                   
                   
                   
                 KGGHRSNPLSAIFTT 
               
               
                   
               
               
                 958 
                 PRT 
                 Human 
                 RSVHC188 
                 QITLKESGPTLVKPTQTLTLTCTFSGFSLSTSG 
               
               
                   
                   
                   
                   
                 MGVSWIRQPPGKALEWLAHIYWDDDKRYNP 
               
               
                   
                   
                   
                   
                 SLKSRLTITKDTSKNQVVLTMTNMDPVDTAT 
               
               
                   
                   
                   
                   
                 YYCARLYGFTYGFAYWGQGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSS 
               
               
                   
                   
                   
                   
                 VVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 
               
               
                   
                   
                   
                   
                 EPKSCDKTHTCPPCPAPPVAGPDVFLFPPKPK 
               
               
                   
                   
                   
                   
                 DTLMISRTPEVTCVVVDVSHEDPEVKFNWYV 
               
               
                   
                   
                   
                   
                 DGVEVHNAKTKPREEQYNSTYRVVSVLTVL 
               
               
                   
                   
                   
                   
                 HQDWLNGKEYKCKVSNAALPAPIAKTISKAK 
               
               
                   
                   
                   
                   
                 GQPREPQVYTLPPSRDELTKNQVSLTCLVKG 
               
               
                   
                   
                   
                   
                 FYPSDIAVEWESNGQPENNYKTTPPVLDSDG 
               
               
                   
                   
                   
                   
                 SFFLYSKLTVDKSRWQQGNVFSCSVMHEAL 
               
               
                   
                   
                   
                   
                 HNHYTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFLIQYQESEKVGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYTVSIYGVKGGHRSNPLSAIFT 
               
               
                   
                   
                   
                   
                 TGGGGSGGGGSGGGGSGGGGSMLPAPKNLV 
               
               
                   
                   
                   
                   
                 VSRVTEDSARLSWTAPDAAFDSFLIQYQESE 
               
               
                   
                   
                   
                   
                 KVGEAIVLTVPGSERSYDLTGLKPGTEYTVSI 
               
               
                   
                   
                   
                   
                 YGVKGGHRSNPLSAIFTT 
               
               
                   
               
               
                 959 
                 PRT 
                 Human 
                 RSVHC189 
                 QITLKESGPTLVKPTQTLTLTCTFSGFSLSTSG 
               
               
                   
                   
                   
                   
                 MGVSWIRQPPGKALEWLAHIYWDDDKRYNP 
               
               
                   
                   
                   
                   
                 SLKSRLTITKDTSKNQVVLTMTNMDPVDTAT 
               
               
                   
                   
                   
                   
                 YYCARLYGFTYGFAYWGQGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSS 
               
               
                   
                   
                   
                   
                 VVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 
               
               
                   
                   
                   
                   
                 EPKSCDKTHTCPPCPAPELLGGPSVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNKALPAPIEKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNHYTQKSLSLSPGKGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSLPAPKNLVVSRVTEDSARLSWTAPD 
               
               
                   
                   
                   
                   
                 AAFDSFLIQYQESEKVGEAIVLTVPGSERSYD 
               
               
                   
                   
                   
                   
                 LTGLKPGTEYTVSIYGVKGGHRSNPLSAIFTT 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSGGGGSLPAPKNLVVS 
               
               
                   
                   
                   
                   
                 RVTEDSARLSWTAPDAAFDSFLIQYQESEKV 
               
               
                   
                   
                   
                   
                 GEAIVLTVPGSERSYDLTGLKPGTEYTVSIYG 
               
               
                   
                   
                   
                   
                 VKGGHRSNPLSAIFTT 
               
               
                   
               
               
                 960 
                 PRT 
                 Human 
                 RSVHC190 
                 QITLKESGPTLVKPTQTLTLTCTFSGFSLSTSG 
               
               
                   
                   
                   
                   
                 MGVSWIRQPPGKALEWLAHIYWDDDKRYNP 
               
               
                   
                   
                   
                   
                 SLKSRLTITKDTSKNQVVLTMTNMDPVDTAT 
               
               
                   
                   
                   
                   
                 YYCARLYGFTYGFAYWGQGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSS 
               
               
                   
                   
                   
                   
                 VVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 
               
               
                   
                   
                   
                   
                 EPKSCDKTHTCPPCPAPELLGGPSVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNKALPAPIEKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNHYTQKSLSLSPGKGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFLIQYQESEKVGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYTVSIYGVKGGHRSNPLSAIFT 
               
               
                   
                   
                   
                   
                 TGGGGSGGGGSGGGGSGGGGSMLPAPKNLV 
               
               
                   
                   
                   
                   
                 VSRVTEDSARLSWTAPDAAFDSFLIQYQESE 
               
               
                   
                   
                   
                   
                 KVGEAIVLTVPGSERSYDLTGLKPGTEYTVSI 
               
               
                   
                   
                   
                   
                 YGVKGGHRSNPLSAIFTT 
               
               
                   
               
               
                 961 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC200 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPELLGGPSVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNKALPAPIEKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFHIEYAEPWVWGEAIVLTVPGSE 
               
               
                   
                   
                   
                   
                 RSYDLTGLKPGTEYVVFIGGVKGGHNSTPLS 
               
               
                   
                   
                   
                   
                 AIFTTGGGGSGGGGSGGGGSGGGGSMLPAPK 
               
               
                   
                   
                   
                   
                 NLVVSRVTEDSARLSWTAPDAAFDSFWITYE 
               
               
                   
                   
                   
                   
                 EKFYRGEAIVLTVPGSERSYDLTGLKPGTEYK 
               
               
                   
                   
                   
                   
                 VWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 962 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC201 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPELLGGPSVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNKALPAPIEKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNHYTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFHIEYAEPWVWGEAIVLTVPGSE 
               
               
                   
                   
                   
                   
                 RSYDLTGLKPGTEYVVFIGGVKGGHNSTPLS 
               
               
                   
                   
                   
                   
                 AIFTTGGGGSGGGGSGGGGSGGGGSMLPAPK 
               
               
                   
                   
                   
                   
                 NLVVSRVTEDSARLSWTAPDAAFDSFWITYE 
               
               
                   
                   
                   
                   
                 EKFYRGEAIVLTVPGSERSYDLTGLKPGTEYK 
               
               
                   
                   
                   
                   
                 VWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 963 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC212 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNHYTQKSLSLSPGKGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFWITYEEKFYRGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYKVWIVGVKGGQGSWPLS 
               
               
                   
                   
                   
                   
                 AIFTT 
               
               
                   
               
               
                 964 
                 PRT 
                 Human 
                 CR- 
                 EQKLISEEDLEVQLVETGGGLVKPGGSLRLSC 
               
               
                   
                   
                   
                 5133HC230 
                 SASRFSFRDYYMTWIRQAPGKGPEWVSHISG 
               
               
                   
                   
                   
                   
                 SGSTIYYADSVRGRFTISRDNAKSSLYLQMDS 
               
               
                   
                   
                   
                   
                 LQADDTAVYYCARGGRATSYYWVHWGPGT 
               
               
                   
                   
                   
                   
                 LVTVSSASTKGPSVFPLAPSSKSTSGGTAALG 
               
               
                   
                   
                   
                   
                 CLVKDYFPEPVTVSWNSGALTSGVHTFPAVL 
               
               
                   
                   
                   
                   
                 QSSGLYSLSSVVTVPSSSLGTQTYICNVNHKP 
               
               
                   
                   
                   
                   
                 SNTKVDKKVEPKSCDKTHTCPPCPAPPVAGP 
               
               
                   
                   
                   
                   
                 DVFLFPPKPKDTLMISRTPEVTCVVVDVSHED 
               
               
                   
                   
                   
                   
                 PEVKFNWYVDGVEVHNAKTKPREEQYNSTY 
               
               
                   
                   
                   
                   
                 RVVSVLTVLHQDWLNGKEYKCKVSNAALPA 
               
               
                   
                   
                   
                   
                 PIAKTISKAKGQPREPQVYTLPPSRDELTKNQ 
               
               
                   
                   
                   
                   
                 VSLTCLVKGFYPSDIAVEWESNGQPENNYKT 
               
               
                   
                   
                   
                   
                 TPPVLDSDGSFFLYSKLTVDKSRWQQGNVFS 
               
               
                   
                   
                   
                   
                 CSVMHEALHNHYTQKSLSLSPGKGGGGSGG 
               
               
                   
                   
                   
                   
                 GGSGGGGSGGGGSMLPAPKNLVVSRVTEDS 
               
               
                   
                   
                   
                   
                 ARLSWTAPDAAFDSFHIEYAEPWVWGEAIVL 
               
               
                   
                   
                   
                   
                 TVPGSERSYDLTGLKPGTEYVVFIGGVKGGH 
               
               
                   
                   
                   
                   
                 NSTPLSAIFTTGGGGSMLPAPKNLVVSRVTED 
               
               
                   
                   
                   
                   
                 SARLSWTAPDAAFDSFWITYEEKFYRGEAIV 
               
               
                   
                   
                   
                   
                 LTVPGSERSYDLTGLKPGTEYKVWIVGVKGG 
               
               
                   
                   
                   
                   
                 QGSWPLSAIFTT 
               
               
                   
               
               
                 965 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC231 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNHYTQKSLSLSPGKGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFWITYEEKFYRGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYKVWIVGVKGGQGSWPLS 
               
               
                   
                   
                   
                   
                 AIFTTDYKDDDDK 
               
               
                   
               
               
                 966 
                 PRT 
                 Human 
                 CR- 
                 EQKLISEEDLEVQLVETGGGLVKPGGSLRLSC 
               
               
                   
                   
                   
                 5133HC232 
                 SASRFSFRDYYMTWIRQAPGKGPEWVSHISG 
               
               
                   
                   
                   
                   
                 SGSTIYYADSVRGRFTISRDNAKSSLYLQMDS 
               
               
                   
                   
                   
                   
                 LQADDTAVYYCARGGRATSYYWVHWGPGT 
               
               
                   
                   
                   
                   
                 LVTVSSASTKGPSVFPLAPSSKSTSGGTAALG 
               
               
                   
                   
                   
                   
                 CLVKDYFPEPVTVSWNSGALTSGVHTFPAVL 
               
               
                   
                   
                   
                   
                 QSSGLYSLSSVVTVPSSSLGTQTYICNVNHKP 
               
               
                   
                   
                   
                   
                 SNTKVDKKVEPKSCDKTHTCPPCPAPPVAGP 
               
               
                   
                   
                   
                   
                 DVFLFPPKPKDTLMISRTPEVTCVVVDVSHED 
               
               
                   
                   
                   
                   
                 PEVKFNWYVDGVEVHNAKTKPREEQYNSTY 
               
               
                   
                   
                   
                   
                 RVVSVLTVLHQDWLNGKEYKCKVSNAALPA 
               
               
                   
                   
                   
                   
                 PIAKTISKAKGQPREPQVYTLPPSRDELTKNQ 
               
               
                   
                   
                   
                   
                 VSLTCLVKGFYPSDIAVEWESNGQPENNYKT 
               
               
                   
                   
                   
                   
                 TPPVLDSDGSFFLYSKLTVDKSRWQQGNVFS 
               
               
                   
                   
                   
                   
                 CSVMHEALHNHYTQKSLSLSPGKGGGGSGG 
               
               
                   
                   
                   
                   
                 GGSGGGGSGGGGSMLPAPKNLVVSRVTEDS 
               
               
                   
                   
                   
                   
                 ARLSWTAPDAAFDSFHIEYAEPWVWGEAIVL 
               
               
                   
                   
                   
                   
                 TVPGSERSYDLTGLKPGTEYVVFIGGVKGGH 
               
               
                   
                   
                   
                   
                 NSTPLSAIFTTGGGGSMLPAPKNLVVSRVTED 
               
               
                   
                   
                   
                   
                 SARLSWTAPDAAFDSFWITYEEKFYRGEAIV 
               
               
                   
                   
                   
                   
                 LTVPGSERSYDLTGLKPGTEYKVWIVGVKGG 
               
               
                   
                   
                   
                   
                 QGSWPLSAIFTTDYKDDDDK 
               
               
                   
               
               
                 967 
                 PRT 
                 Human 
                 CR- 
                 EQKLISEEDLEVQLVETGGGLVKPGGSLRLSC 
               
               
                   
                   
                   
                 5133HC233 
                 SASRFSFRDYYMTWIRQAPGKGPEWVSHISG 
               
               
                   
                   
                   
                   
                 SGSTIYYADSVRGRFTISRDNAKSSLYLQMDS 
               
               
                   
                   
                   
                   
                 LQADDTAVYYCARGGRATSYYWVHWGPGT 
               
               
                   
                   
                   
                   
                 LVTVSSASTKGPSVFPLAPSSKSTSGGTAALG 
               
               
                   
                   
                   
                   
                 CLVKDYFPEPVTVSWNSGALTSGVHTFPAVL 
               
               
                   
                   
                   
                   
                 QSSGLYSLSSVVTVPSSSLGTQTYICNVNHKP 
               
               
                   
                   
                   
                   
                 SNTKVDKKVEPKSCDKTHTCPPCPAPPVAGP 
               
               
                   
                   
                   
                   
                 DVFLFPPKPKDTLMISRTPEVTCVVVDVSHED 
               
               
                   
                   
                   
                   
                 PEVKFNWYVDGVEVHNAKTKPREEQYNSTY 
               
               
                   
                   
                   
                   
                 RVVSVLTVLHQDWLNGKEYKCKVSNAALPA 
               
               
                   
                   
                   
                   
                 PIAKTISKAKGQPREPQVYTLPPSRDELTKNQ 
               
               
                   
                   
                   
                   
                 VSLTCLVKGFYPSDIAVEWESNGQPENNYKT 
               
               
                   
                   
                   
                   
                 TPPVLDSDGSFFLYSKLTVDKSRWQQGNVFS 
               
               
                   
                   
                   
                   
                 CSVMHEALHNRFTQKSLSLSPGKGGGGSGG 
               
               
                   
                   
                   
                   
                 GGSGGGGSGGGGSMLPAPKNLVVSRVTEDS 
               
               
                   
                   
                   
                   
                 ARLSWTAPDAAFDSFHIEYAEPWVWGEAIVL 
               
               
                   
                   
                   
                   
                 TVPGSERSYDLTGLKPGTEYVVFIGGVKGGH 
               
               
                   
                   
                   
                   
                 NSTPLSAIFTTGGGGSMLPAPKNLVVSRVTED 
               
               
                   
                   
                   
                   
                 SARLSWTAPDAAFDSFWITYEEKFYRGEAIV 
               
               
                   
                   
                   
                   
                 LTVPGSERSYDLTGLKPGTEYKVWIVGVKGG 
               
               
                   
                   
                   
                   
                 QGSWPLSAIFTT 
               
               
                   
               
               
                 968 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC234 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFWITYEEKFYRGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYKVWIVGVKGGQGSWPLS 
               
               
                   
                   
                   
                   
                 AIFTTDYKDDDDK 
               
               
                   
               
               
                 969 
                 PRT 
                 Human 
                 CR- 
                 EQKLISEEDLEVQLVETGGGLVKPGGSLRLSC 
               
               
                   
                   
                   
                 5133HC235 
                 SASRFSFRDYYMTWIRQAPGKGPEWVSHISG 
               
               
                   
                   
                   
                   
                 SGSTIYYADSVRGRFTISRDNAKSSLYLQMDS 
               
               
                   
                   
                   
                   
                 LQADDTAVYYCARGGRATSYYWVHWGPGT 
               
               
                   
                   
                   
                   
                 LVTVSSASTKGPSVFPLAPSSKSTSGGTAALG 
               
               
                   
                   
                   
                   
                 CLVKDYFPEPVTVSWNSGALTSGVHTFPAVL 
               
               
                   
                   
                   
                   
                 QSSGLYSLSSVVTVPSSSLGTQTYICNVNHKP 
               
               
                   
                   
                   
                   
                 SNTKVDKKVEPKSCDKTHTCPPCPAPPVAGP 
               
               
                   
                   
                   
                   
                 DVFLFPPKPKDTLMISRTPEVTCVVVDVSHED 
               
               
                   
                   
                   
                   
                 PEVKFNWYVDGVEVHNAKTKPREEQYNSTY 
               
               
                   
                   
                   
                   
                 RVVSVLTVLHQDWLNGKEYKCKVSNAALPA 
               
               
                   
                   
                   
                   
                 PIAKTISKAKGQPREPQVYTLPPSRDELTKNQ 
               
               
                   
                   
                   
                   
                 VSLTCLVKGFYPSDIAVEWESNGQPENNYKT 
               
               
                   
                   
                   
                   
                 TPPVLDSDGSFFLYSKLTVDKSRWQQGNVFS 
               
               
                   
                   
                   
                   
                 CSVMHEALHNHYTQKSLSLSPGKGGGGSGG 
               
               
                   
                   
                   
                   
                 GGSGGGGSGGGGSMLPAPKNLVVSRVTEDS 
               
               
                   
                   
                   
                   
                 ARLSWTAPDAAFDSFHIEYAEPWVWGEAIVL 
               
               
                   
                   
                   
                   
                 TVPGSERSYDLTGLKPGTEYVVFIGGVKGGH 
               
               
                   
                   
                   
                   
                 NSTPLSAIFTTGGGGSGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FWITYEEKFYRGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 970 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC236 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNHYTQKSLSLSPGKGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHNSTPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSMLPAPKNL 
               
               
                   
                   
                   
                   
                 VVSRVTEDSARLSWTAPDAAFDSFWITYEEK 
               
               
                   
                   
                   
                   
                 FYRGEAIVLTVPGSERSYDLTGLKPGTEYKV 
               
               
                   
                   
                   
                   
                 WIVGVKGGQGSWPLSAIFTTDYKDDDDK 
               
               
                   
               
               
                 971 
                 PRT 
                 Human 
                 CR- 
                 EQKLISEEDLEVQLVETGGGLVKPGGSLRLSC 
               
               
                   
                   
                   
                 5133HC237 
                 SASRFSFRDYYMTWIRQAPGKGPEWVSHISG 
               
               
                   
                   
                   
                   
                 SGSTIYYADSVRGRFTISRDNAKSSLYLQMDS 
               
               
                   
                   
                   
                   
                 LQADDTAVYYCARGGRATSYYWVHWGPGT 
               
               
                   
                   
                   
                   
                 LVTVSSASTKGPSVFPLAPSSKSTSGGTAALG 
               
               
                   
                   
                   
                   
                 CLVKDYFPEPVTVSWNSGALTSGVHTFPAVL 
               
               
                   
                   
                   
                   
                 QSSGLYSLSSVVTVPSSSLGTQTYICNVNHKP 
               
               
                   
                   
                   
                   
                 SNTKVDKKVEPKSCDKTHTCPPCPAPPVAGP 
               
               
                   
                   
                   
                   
                 DVFLFPPKPKDTLMISRTPEVTCVVVDVSHED 
               
               
                   
                   
                   
                   
                 PEVKFNWYVDGVEVHNAKTKPREEQYNSTY 
               
               
                   
                   
                   
                   
                 RVVSVLTVLHQDWLNGKEYKCKVSNAALPA 
               
               
                   
                   
                   
                   
                 PIAKTISKAKGQPREPQVYTLPPSRDELTKNQ 
               
               
                   
                   
                   
                   
                 VSLTCLVKGFYPSDIAVEWESNGQPENNYKT 
               
               
                   
                   
                   
                   
                 TPPVLDSDGSFFLYSKLTVDKSRWQQGNVFS 
               
               
                   
                   
                   
                   
                 CSVMHEALHNHYTQKSLSLSPGKGGGGSGG 
               
               
                   
                   
                   
                   
                 GGSGGGGSGGGGSMLPAPKNLVVSRVTEDS 
               
               
                   
                   
                   
                   
                 ARLSWTAPDAAFDSFHIEYAEPWVWGEAIVL 
               
               
                   
                   
                   
                   
                 TVPGSERSYDLTGLKPGTEYVVFIGGVKGGH 
               
               
                   
                   
                   
                   
                 NSTPLSAIFTTGGGGSGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FWITYEEKFYRGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYKVWIVGVKGGQGSWPLSAIFTTDYKD 
               
               
                   
                   
                   
                   
                 DDDK 
               
               
                   
               
               
                 972 
                 PRT 
                 Human 
                 CR- 
                 EQKLISEEDLEVQLVETGGGLVKPGGSLRLSC 
               
               
                   
                   
                   
                 5133HC238 
                 SASRFSFRDYYMTWIRQAPGKGPEWVSHISG 
               
               
                   
                   
                   
                   
                 SGSTIYYADSVRGRFTISRDNAKSSLYLQMDS 
               
               
                   
                   
                   
                   
                 LQADDTAVYYCARGGRATSYYWVHWGPGT 
               
               
                   
                   
                   
                   
                 LVTVSSASTKGPSVFPLAPSSKSTSGGTAALG 
               
               
                   
                   
                   
                   
                 CLVKDYFPEPVTVSWNSGALTSGVHTFPAVL 
               
               
                   
                   
                   
                   
                 QSSGLYSLSSVVTVPSSSLGTQTYICNVNHKP 
               
               
                   
                   
                   
                   
                 SNTKVDKKVEPKSCDKTHTCPPCPAPPVAGP 
               
               
                   
                   
                   
                   
                 DVFLFPPKPKDTLMISRTPEVTCVVVDVSHED 
               
               
                   
                   
                   
                   
                 PEVKFNWYVDGVEVHNAKTKPREEQYNSTY 
               
               
                   
                   
                   
                   
                 RVVSVLTVLHQDWLNGKEYKCKVSNAALPA 
               
               
                   
                   
                   
                   
                 PIAKTISKAKGQPREPQVYTLPPSRDELTKNQ 
               
               
                   
                   
                   
                   
                 VSLTCLVKGFYPSDIAVEWESNGQPENNYKT 
               
               
                   
                   
                   
                   
                 TPPVLDSDGSFFLYSKLTVDKSRWQQGNVFS 
               
               
                   
                   
                   
                   
                 CSVMHEALHNRFTQKSLSLSPGKGGGGSGG 
               
               
                   
                   
                   
                   
                 GGSGGGGSGGGGSMLPAPKNLVVSRVTEDS 
               
               
                   
                   
                   
                   
                 ARLSWTAPDAAFDSFHIEYAEPWVWGEAIVL 
               
               
                   
                   
                   
                   
                 TVPGSERSYDLTGLKPGTEYVVFIGGVKGGH 
               
               
                   
                   
                   
                   
                 NSTPLSAIFTTGGGGSMLPAPKNLVVSRVTED 
               
               
                   
                   
                   
                   
                 SARLSWTAPDAAFDSFWITYEEKFYRGEAIV 
               
               
                   
                   
                   
                   
                 LTVPGSERSYDLTGLKPGTEYKVWIVGVKGG 
               
               
                   
                   
                   
                   
                 QGSWPLSAIFTTDYKDDDDK 
               
               
                   
               
               
                 973 
                 PRT 
                 Human 
                 CR- 
                 DYKDDDDKEVQLVETGGGLVKPGGSLRLSC 
               
               
                   
                   
                   
                 5133HC239 
                 SASRFSFRDYYMTWIRQAPGKGPEWVSHISG 
               
               
                   
                   
                   
                   
                 SGSTIYYADSVRGRFTISRDNAKSSLYLQMDS 
               
               
                   
                   
                   
                   
                 LQADDTAVYYCARGGRATSYYWVHWGPGT 
               
               
                   
                   
                   
                   
                 LVTVSSASTKGPSVFPLAPSSKSTSGGTAALG 
               
               
                   
                   
                   
                   
                 CLVKDYFPEPVTVSWNSGALTSGVHTFPAVL 
               
               
                   
                   
                   
                   
                 QSSGLYSLSSVVTVPSSSLGTQTYICNVNHKP 
               
               
                   
                   
                   
                   
                 SNTKVDKKVEPKSCDKTHTCPPCPAPPVAGP 
               
               
                   
                   
                   
                   
                 DVFLFPPKPKDTLMISRTPEVTCVVVDVSHED 
               
               
                   
                   
                   
                   
                 PEVKFNWYVDGVEVHNAKTKPREEQYNSTY 
               
               
                   
                   
                   
                   
                 RVVSVLTVLHQDWLNGKEYKCKVSNAALPA 
               
               
                   
                   
                   
                   
                 PIAKTISKAKGQPREPQVYTLPPSRDELTKNQ 
               
               
                   
                   
                   
                   
                 VSLTCLVKGFYPSDIAVEWESNGQPENNYKT 
               
               
                   
                   
                   
                   
                 TPPVLDSDGSFFLYSKLTVDKSRWQQGNVFS 
               
               
                   
                   
                   
                   
                 CSVMHEALHNRFTQKSLSLSPGKGGGGSGG 
               
               
                   
                   
                   
                   
                 GGSGGGGSGGGGSMLPAPKNLVVSRVTEDS 
               
               
                   
                   
                   
                   
                 ARLSWTAPDAAFDSFHIEYAEPWVWGEAIVL 
               
               
                   
                   
                   
                   
                 TVPGSERSYDLTGLKPGTEYVVFIGGVKGGH 
               
               
                   
                   
                   
                   
                 NSTPLSAIFTTGGGGSGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FWITYEEKFYRGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 974 
                 PRT 
                 Human 
                 CR- 
                 DYKDDDDKEVQLVETGGGLVKPGGSLRLSC 
               
               
                   
                   
                   
                 5133HC240 
                 SASRFSFRDYYMTWIRQAPGKGPEWVSHISG 
               
               
                   
                   
                   
                   
                 SGSTIYYADSVRGRFTISRDNAKSSLYLQMDS 
               
               
                   
                   
                   
                   
                 LQADDTAVYYCARGGRATSYYWVHWGPGT 
               
               
                   
                   
                   
                   
                 LVTVSSASTKGPSVFPLAPSSKSTSGGTAALG 
               
               
                   
                   
                   
                   
                 CLVKDYFPEPVTVSWNSGALTSGVHTFPAVL 
               
               
                   
                   
                   
                   
                 QSSGLYSLSSVVTVPSSSLGTQTYICNVNHKP 
               
               
                   
                   
                   
                   
                 SNTKVDKKVEPKSCDKTHTCPPCPAPPVAGP 
               
               
                   
                   
                   
                   
                 DVFLFPPKPKDTLMISRTPEVTCVVVDVSHED 
               
               
                   
                   
                   
                   
                 PEVKFNWYVDGVEVHNAKTKPREEQYNSTY 
               
               
                   
                   
                   
                   
                 RVVSVLTVLHQDWLNGKEYKCKVSNAALPA 
               
               
                   
                   
                   
                   
                 PIAKTISKAKGQPREPQVYTLPPSRDELTKNQ 
               
               
                   
                   
                   
                   
                 VSLTCLVKGFYPSDIAVEWESNGQPENNYKT 
               
               
                   
                   
                   
                   
                 TPPVLDSDGSFFLYSKLTVDKSRWQQGNVFS 
               
               
                   
                   
                   
                   
                 CSVMHEALHNHYTQKSLSLSPGKGGGGSGG 
               
               
                   
                   
                   
                   
                 GGSGGGGSGGGGSMLPAPKNLVVSRVTEDS 
               
               
                   
                   
                   
                   
                 ARLSWTAPDAAFDSFHIEYAEPWVWGEAIVL 
               
               
                   
                   
                   
                   
                 TVPGSERSYDLTGLKPGTEYVVFIGGVKGGH 
               
               
                   
                   
                   
                   
                 NSTPLSAIFTTGGGGSGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FWITYEEKFYRGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYKVWIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 975 
                 PRT 
                 Human 
                 CR- 
                 DYKDDDDKEVQLVETGGGLVKPGGSLRLSC 
               
               
                   
                   
                   
                 5133HC241 
                 SASRFSFRDYYMTWIRQAPGKGPEWVSHISG 
               
               
                   
                   
                   
                   
                 SGSTIYYADSVRGRFTISRDNAKSSLYLQMDS 
               
               
                   
                   
                   
                   
                 LQADDTAVYYCARGGRATSYYWVHWGPGT 
               
               
                   
                   
                   
                   
                 LVTVSSASTKGPSVFPLAPSSKSTSGGTAALG 
               
               
                   
                   
                   
                   
                 CLVKDYFPEPVTVSWNSGALTSGVHTFPAVL 
               
               
                   
                   
                   
                   
                 QSSGLYSLSSVVTVPSSSLGTQTYICNVNHKP 
               
               
                   
                   
                   
                   
                 SNTKVDKKVEPKSCDKTHTCPPCPAPPVAGP 
               
               
                   
                   
                   
                   
                 DVFLFPPKPKDTLMISRTPEVTCVVVDVSHED 
               
               
                   
                   
                   
                   
                 PEVKFNWYVDGVEVHNAKTKPREEQYNSTY 
               
               
                   
                   
                   
                   
                 RVVSVLTVLHQDWLNGKEYKCKVSNAALPA 
               
               
                   
                   
                   
                   
                 PIAKTISKAKGQPREPQVYTLPPSRDELTKNQ 
               
               
                   
                   
                   
                   
                 VSLTCLVKGFYPSDIAVEWESNGQPENNYKT 
               
               
                   
                   
                   
                   
                 TPPVLDSDGSFFLYSKLTVDKSRWQQGNVFS 
               
               
                   
                   
                   
                   
                 CSVMHEALHNRFTQKSLSLSPGKGGGGSGG 
               
               
                   
                   
                   
                   
                 GGSGGGGSGGGGSMLPAPKNLVVSRVTEDS 
               
               
                   
                   
                   
                   
                 ARLSWTAPDAAFDSFHIEYAEPWVWGEAIVL 
               
               
                   
                   
                   
                   
                 TVPGSERSYDLTGLKPGTEYVVFIGGVKGGH 
               
               
                   
                   
                   
                   
                 NSTPLSAIFTTGGGGSMLPAPKNLVVSRVTED 
               
               
                   
                   
                   
                   
                 SARLSWTAPDAAFDSFWITYEEKFYRGEAIV 
               
               
                   
                   
                   
                   
                 LTVPGSERSYDLTGLKPGTEYKVWIVGVKGG 
               
               
                   
                   
                   
                   
                 QGSWPLSAIFTT 
               
               
                   
               
               
                 976 
                 PRT 
                 Human 
                 CR- 
                 DYKDDDDKEVQLVETGGGLVKPGGSLRLSC 
               
               
                   
                   
                   
                 5133HC242 
                 SASRFSFRDYYMTWIRQAPGKGPEWVSHISG 
               
               
                   
                   
                   
                   
                 SGSTIYYADSVRGRFTISRDNAKSSLYLQMDS 
               
               
                   
                   
                   
                   
                 LQADDTAVYYCARGGRATSYYWVHWGPGT 
               
               
                   
                   
                   
                   
                 LVTVSSASTKGPSVFPLAPSSKSTSGGTAALG 
               
               
                   
                   
                   
                   
                 CLVKDYFPEPVTVSWNSGALTSGVHTFPAVL 
               
               
                   
                   
                   
                   
                 QSSGLYSLSSVVTVPSSSLGTQTYICNVNHKP 
               
               
                   
                   
                   
                   
                 SNTKVDKKVEPKSCDKTHTCPPCPAPPVAGP 
               
               
                   
                   
                   
                   
                 DVFLFPPKPKDTLMISRTPEVTCVVVDVSHED 
               
               
                   
                   
                   
                   
                 PEVKFNWYVDGVEVHNAKTKPREEQYNSTY 
               
               
                   
                   
                   
                   
                 RVVSVLTVLHQDWLNGKEYKCKVSNAALPA 
               
               
                   
                   
                   
                   
                 PIAKTISKAKGQPREPQVYTLPPSRDELTKNQ 
               
               
                   
                   
                   
                   
                 VSLTCLVKGFYPSDIAVEWESNGQPENNYKT 
               
               
                   
                   
                   
                   
                 TPPVLDSDGSFFLYSKLTVDKSRWQQGNVFS 
               
               
                   
                   
                   
                   
                 CSVMHEALHNHYTQKSLSLSPGKGGGGSGG 
               
               
                   
                   
                   
                   
                 GGSGGGGSGGGGSMLPAPKNLVVSRVTEDS 
               
               
                   
                   
                   
                   
                 ARLSWTAPDAAFDSFHIEYAEPWVWGEAIVL 
               
               
                   
                   
                   
                   
                 TVPGSERSYDLTGLKPGTEYVVFIGGVKGGH 
               
               
                   
                   
                   
                   
                 NSTPLSAIFTTGGGGSMLPAPKNLVVSRVTED 
               
               
                   
                   
                   
                   
                 SARLSWTAPDAAFDSFWITYEEKFYRGEAIV 
               
               
                   
                   
                   
                   
                 LTVPGSERSYDLTGLKPGTEYKVWIVGVKGG 
               
               
                   
                   
                   
                   
                 QGSWPLSAIFTT 
               
               
                   
               
               
                 977 
                 PRT 
                 Human 
                 RSVHC65 
                 QITLKESGPTLVKPTQTLTLTCTFSGFSLSTSG 
               
               
                   
                   
                   
                   
                 MGVSWIRQPPGKALEWLAHIYWDDDKRYNP 
               
               
                   
                   
                   
                   
                 SLKSRLTITKDTSKNQVVLTMTNMDPVDTAT 
               
               
                   
                   
                   
                   
                 YYCARLYGFTYGFAYWGQGTLVTVSSASTK 
               
               
                   
                   
                   
                   
                 GPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP 
               
               
                   
                   
                   
                   
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSS 
               
               
                   
                   
                   
                   
                 VVTVPSSSLGTQTYICNVNHKPSNTKVDKKV 
               
               
                   
                   
                   
                   
                 EPKSCDKTHTCPPCPAPPVAGPDVFLFPPKPK 
               
               
                   
                   
                   
                   
                 DTLMISRTPEVTCVVVDVSHEDPEVKFNWYV 
               
               
                   
                   
                   
                   
                 DGVEVHNAKTKPREEQYNSTYRVVSVLTVL 
               
               
                   
                   
                   
                   
                 HQDWLNGKEYKCKVSNAALPAPIAKTISKAK 
               
               
                   
                   
                   
                   
                 GQPREPQVYTLPPSRDELTKNQVSLTCLVKG 
               
               
                   
                   
                   
                   
                 FYPSDIAVEWESNGQPENNYKTTPPVLDSDG 
               
               
                   
                   
                   
                   
                 SFFLYSKLTVDKSRWQQGNVFSCSVMHEAL 
               
               
                   
                   
                   
                   
                 HNRFTQKSLSLSPGKGGGGSGGGGSGGGGSG 
               
               
                   
                   
                   
                   
                 GGGSLPAPKNLVVSRVTEDSARLSWTAPDAA 
               
               
                   
                   
                   
                   
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                   
                 GLKPGTEYTVSIYGVKGGHRSNPLSAIFTT 
               
               
                   
               
               
                 978 
                 PRT 
                 Human 
                 CR- 
                 EIVLTQSPATLSLSPGERATLSCRASQSVSGYL 
               
               
                   
                   
                   
                 5133LC290 
                 GWYQQKPGQAPRLLIYGASSRATGIPDRFSG 
               
               
                   
                   
                   
                   
                 SGSGTDFTLTISRLEPEDFAVYYCQQYGSSPL 
               
               
                   
                   
                   
                   
                 TFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGT 
               
               
                   
                   
                   
                   
                 ASVVCLLNNFYPREAKVQWKVDNALQSGNS 
               
               
                   
                   
                   
                   
                 QESVTEQDSKDSTYSLSSTLTLSKADYEKHK 
               
               
                   
                   
                   
                   
                 VYACEVTHQGLSSPVTKSFNRGECGGGGSGG 
               
               
                   
                   
                   
                   
                 GGSGGGGSGGGGSMLPAPKNLVVSRVTEDS 
               
               
                   
                   
                   
                   
                 ARLSWTAPDAAFDSFLIQYQESEKVGEAIVLT 
               
               
                   
                   
                   
                   
                 VPGSERSYDLTGLKPGTEYTVSIYGVKGGHR 
               
               
                   
                   
                   
                   
                 SNPLSAIFTT 
               
               
                   
               
               
                 979 
                 PRT 
                 Human 
                 CR- 
                 EIVLTQSPATLSLSPGERATLSCRASQSVSGYL 
               
               
                   
                   
                   
                 5133LC291 
                 GWYQQKPGQAPRLLIYGASSRATGIPDRFSG 
               
               
                   
                   
                   
                   
                 SGSGTDFTLTISRLEPEDFAVYYCQQYGSSPL 
               
               
                   
                   
                   
                   
                 TFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGT 
               
               
                   
                   
                   
                   
                 ASVVCLLNNFYPREAKVQWKVDNALQSGNS 
               
               
                   
                   
                   
                   
                 QESVTEQDSKDSTYSLSSTLTLSKADYEKHK 
               
               
                   
                   
                   
                   
                 VYACEVTHQGLSSPVTKSFNRGECGGGGSGG 
               
               
                   
                   
                   
                   
                 GGSGGGGSGGGGSMLPAPKNLVVSRVTEDS 
               
               
                   
                   
                   
                   
                 ARLSWTAPDAAFDSFWITYEEKFYRGEAIVL 
               
               
                   
                   
                   
                   
                 TVPGSERSYDLTGLKPGTEYKVWIVGVKGG 
               
               
                   
                   
                   
                   
                 QGSWPLSAIFTT 
               
               
                   
               
               
                 980 
                 PRT 
                 Human 
                 CR- 
                 EIVLTQSPATLSLSPGERATLSCRASQSVSGYL 
               
               
                   
                   
                   
                 5133LC292 
                 GWYQQKPGQAPRLLIYGASSRATGIPDRFSG 
               
               
                   
                   
                   
                   
                 SGSGTDFTLTISRLEPEDFAVYYCQQYGSSPL 
               
               
                   
                   
                   
                   
                 TFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGT 
               
               
                   
                   
                   
                   
                 ASVVCLLNNFYPREAKVQWKVDNALQSGNS 
               
               
                   
                   
                   
                   
                 QESVTEQDSKDSTYSLSSTLTLSKADYEKHK 
               
               
                   
                   
                   
                   
                 VYACEVTHQGLSSPVTKSFNRGECGGGGSGG 
               
               
                   
                   
                   
                   
                 GGSGGGGSGGGGSMLPAPKNLVVSRVTEDS 
               
               
                   
                   
                   
                   
                 ARLSWTAPDAAFDSFHIEYAEPWVWGEAIVL 
               
               
                   
                   
                   
                   
                 TVPGSERSYDLTGLKPGTEYVVFIGGVKGGH 
               
               
                   
                   
                   
                   
                 NSTPLSAIFTT 
               
               
                   
               
               
                 981 
                 PRT 
                 Human 
                 RSVLC343 
                 DIVMTQSPDSLAVSLGERATINCRASQSVDY 
               
               
                   
                   
                   
                   
                 NGISYMHWYQQKPGQPPKLLIYAASNPESGV 
               
               
                   
                   
                   
                   
                 PDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQ 
               
               
                   
                   
                   
                   
                 IIEDPWTFGQGTKVEIKRTVAAPSVFIFPPSDE 
               
               
                   
                   
                   
                   
                 QLKSGTASVVCLLNNFYPREAKVQWKVDNA 
               
               
                   
                   
                   
                   
                 LQSGNSQESVTEQDSKDSTYSLSSTLTLSKAD 
               
               
                   
                   
                   
                   
                 YEKHKVYACEVTHQGLSSPVTKSFNRGECG 
               
               
                   
                   
                   
                   
                 GGGSGGGGSGGGGSGGGGSMLPAPKNLVVS 
               
               
                   
                   
                   
                   
                 RVTEDSARLSWTAPDAAFDSFLIQYQESEKV 
               
               
                   
                   
                   
                   
                 GEAIVLTVPGSERSYDLTGLKPGTEYTVSIYG 
               
               
                   
                   
                   
                   
                 VKGGHRSNPLSAIFTT 
               
               
                   
               
               
                 982 
                 PRT 
                 Human 
                 RSVLC344 
                 DIVMTQSPDSLAVSLGERATINCRASQSVDY 
               
               
                   
                   
                   
                   
                 NGISYMHWYQQKPGQPPKLLIYAASNPESGV 
               
               
                   
                   
                   
                   
                 PDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQ 
               
               
                   
                   
                   
                   
                 IIEDPWTFGQGTKVEIKRTVAAPSVFIFPPSDE 
               
               
                   
                   
                   
                   
                 QLKSGTASVVCLLNNFYPREAKVQWKVDNA 
               
               
                   
                   
                   
                   
                 LQSGNSQESVTEQDSKDSTYSLSSTLTLSKAD 
               
               
                   
                   
                   
                   
                 YEKHKVYACEVTHQGLSSPVTKSFNRGECG 
               
               
                   
                   
                   
                   
                 GGGSGGGGSGGGGSGGGGSMLPAPKNLVVS 
               
               
                   
                   
                   
                   
                 RVTEDSARLSWTAPDAAFDSFWITYEEKFYR 
               
               
                   
                   
                   
                   
                 GEAIVLTVPGSERSYDLTGLKPGTEYKVWIV 
               
               
                   
                   
                   
                   
                 GVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 983 
                 PRT 
                 Human 
                 RSVLC345 
                 DIVMTQSPDSLAVSLGERATINCRASQSVDY 
               
               
                   
                   
                   
                   
                 NGISYMHWYQQKPGQPPKLLIYAASNPESGV 
               
               
                   
                   
                   
                   
                 PDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQ 
               
               
                   
                   
                   
                   
                 IIEDPWTFGQGTKVEIKRTVAAPSVFIFPPSDE 
               
               
                   
                   
                   
                   
                 QLKSGTASVVCLLNNFYPREAKVQWKVDNA 
               
               
                   
                   
                   
                   
                 LQSGNSQESVTEQDSKDSTYSLSSTLTLSKAD 
               
               
                   
                   
                   
                   
                 YEKHKVYACEVTHQGLSSPVTKSFNRGECG 
               
               
                   
                   
                   
                   
                 GGGSGGGGSGGGGSGGGGSMLPAPKNLVVS 
               
               
                   
                   
                   
                   
                 RVTEDSARLSWTAPDAAFDSFHIEYAEPWV 
               
               
                   
                   
                   
                   
                 WGEAIVLTVPGSERSYDLTGLKPGTEYVVFIG 
               
               
                   
                   
                   
                   
                 GVKGGHNSTPLSAIFTT 
               
               
                   
               
               
                 984 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC355 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFGIGYLEYPWYGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYFVDIYGVKGGWWSYPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSMLPAPKNL 
               
               
                   
                   
                   
                   
                 VVSRVTEDSARLSWTAPDAAFDSFWITYEEK 
               
               
                   
                   
                   
                   
                 FYRGEAIVLTVPGSERSYDLTGLKPGTEYKV 
               
               
                   
                   
                   
                   
                 WIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 985 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC356 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFNIDYFEYYEFGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYFVDIYGVKGGSWSLPLSAIFT 
               
               
                   
                   
                   
                   
                 TGGGGSGGGGSGGGGSGGGGSMLPAPKNLV 
               
               
                   
                   
                   
                   
                 VSRVTEDSARLSWTAPDAAFDSFWITYEEKF 
               
               
                   
                   
                   
                   
                 YRGEAIVLTVPGSERSYDLTGLKPGTEYKVW 
               
               
                   
                   
                   
                   
                 IVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 986 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC357 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFNIHYAEYPDFGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYIVDIWGVKGGLGSWPLSAIFT 
               
               
                   
                   
                   
                   
                 TGGGGSGGGGSGGGGSGGGGSMLPAPKNLV 
               
               
                   
                   
                   
                   
                 VSRVTEDSARLSWTAPDAAFDSFWITYEEKF 
               
               
                   
                   
                   
                   
                 YRGEAIVLTVPGSERSYDLTGLKPGTEYKVW 
               
               
                   
                   
                   
                   
                 IVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 987 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC358 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHASTPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSMLPAPKNL 
               
               
                   
                   
                   
                   
                 VVSRVTEDSARLSWTAPDAAFDSFWITYEEK 
               
               
                   
                   
                   
                   
                 FYRGEAIVLTVPGSERSYDLTGLKPGTEYKV 
               
               
                   
                   
                   
                   
                 WIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 988 
                 PRT 
                 Human 
                 CR- 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                 5133HC359 
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFHIEYAEPWVWGEAIVLTVPGSERS 
               
               
                   
                   
                   
                   
                 YDLTGLKPGTEYVVFIGGVKGGHSSTPLSAIF 
               
               
                   
                   
                   
                   
                 TTGGGGSGGGGSGGGGSGGGGSMLPAPKNL 
               
               
                   
                   
                   
                   
                 VVSRVTEDSARLSWTAPDAAFDSFWITYEEK 
               
               
                   
                   
                   
                   
                 FYRGEAIVLTVPGSERSYDLTGLKPGTEYKV 
               
               
                   
                   
                   
                   
                 WIVGVKGGQGSWPLSAIFTT 
               
               
                   
               
               
                 989 
                 PRT 
                 Artificial 
                 Luk26 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 Consensus 
                 X 32 I X 34 Y X 36 E X 38  X 39  X 40  X 41  X 42 EAI 
               
               
                   
                   
                   
                 Sequence 
                 X 46 LTVPGSERSYDLTGLKPGT X 66 Y X 68 V X 70 I 
               
               
                   
                   
                   
                   
                 X 72 GVKG X 77  X 78  X 79  S X 81  X 82 L X 84 A X 86 FTT 
               
               
                   
                   
                   
                   
                 X 32  is any amino acid residue, X 34  is E, X 36  is any 
               
               
                   
                   
                   
                   
                 amino acid residue, X 38  is any amino acid residue, 
               
               
                   
                   
                   
                   
                 X 39  is W or a functionally equivalent amino acid 
               
               
                   
                   
                   
                   
                 residue, X 40  is any amino acid residue, X 41  is W, 
               
               
                   
                   
                   
                   
                 X 42  is any amino acid residue, X 46  is any amino 
               
               
                   
                   
                   
                   
                 acid residue, X 66  is any amino acid residue, X 68  is 
               
               
                   
                   
                   
                   
                 any amino acid residue, X 70  is F, X 72  is G, X 77  is 
               
               
                   
                   
                   
                   
                 any amino acid residue, X 78  is any amino acid 
               
               
                   
                   
                   
                   
                 residue, X 79  is any amino acid residue, X 81  is any 
               
               
                   
                   
                   
                   
                 amino acid residue, X 82  is any amino acid residue, 
               
               
                   
                   
                   
                   
                 X 84  is any amino acid residue, and X 86  is any amino 
               
               
                   
                   
                   
                   
                 acid residue. 
               
               
                   
               
               
                 990 
                 PRT 
                 Artificial 
                 Luk27 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 Consensus 
                 X 32 I X 34 Y X 36 E X 38  X 39  X 40  X 41  GEAI 
               
               
                   
                   
                   
                 Sequence 
                 VLTVPGSERSYDLTGLKPGT EY X 68 V X 70 I 
               
               
                   
                   
                   
                   
                 X 72 GVKG G X 78  X 79  S X 81  PLSAIFTT 
               
               
                   
                   
                   
                   
                 X 32  is any amino acid residue, X 34  is any amino 
               
               
                   
                   
                   
                   
                 acid residue, X 36  is any amino acid residue, X 38  is 
               
               
                   
                   
                   
                   
                 W, X 39  is any amino acid residue, X 40  is any amino 
               
               
                   
                   
                   
                   
                 acid residue 
               
               
                   
                   
                   
                   
                 X 41  is any amino acid residue, X 68  is L, X 70  is D, 
               
               
                   
                   
                   
                   
                 X 72  is Y, X 78  is any amino acid residue, 
               
               
                   
                   
                   
                   
                 X 79  is W, and X 81  is Y. 
               
               
                   
               
               
                 991 
                 PRT 
                 Artificial 
                 Luk38 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 Consensus 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 Sequence 
                 GTEYTVSIYGV X 75  X 76  X 77  X 78  X 79  X 80 X 81  X 82   
               
               
                   
                   
                   
                   
                 X 83  X 84  X 85  X 86  SNPLSAIFTT 
               
               
                   
                   
                   
                   
                 X 75  is any amino acid residue, X 76  is any amino 
               
               
                   
                   
                   
                   
                 acid residue, X 77  is I, X 78  is any amino acid 
               
               
                   
                   
                   
                   
                 residue, X 79  is any amino acid residue, 
               
               
                   
                   
                   
                   
                 X 80  is G, X 81  is W, X 82  is L, X 83  is D, 
               
               
                   
                   
                   
                   
                 X 84  is F, X 85  is V, and X 86  is F. 
               
               
                   
               
               
                 992 
                 PRT 
                 Artificial 
                 Luk17 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 Consensus 
                 X 32 I X 34 Y X 36 E X 38  X 39  X 40  X 41  X 42 EAI 
               
               
                   
                   
                   
                   
                 X 46 LTVPGSERSYDLTGLKPGTX 66 Y X 68 V X 70 I 
               
               
                   
                   
                   
                   
                 X 72 GVKG X 77  X 78  X 79  S X 81  X 82 L X 84 A X 86 FTT 
               
               
                   
                   
                   
                   
                 X 32  is W, X 34  is any amino acid residue, 
               
               
                   
                   
                   
                   
                 X 36  is E, X 38  is K, X 39  is F, X 40  is Y, X 41  is R, 
               
               
                   
                   
                   
                   
                 X 42  is any amino acid residue, X 42  is any amino 
               
               
                   
                   
                   
                   
                 acid residue, X 46  is any amino acid residue, X 66  is 
               
               
                   
                   
                   
                   
                 any amino acid residue, X 68  is K, X 70  is W, X 72  is 
               
               
                   
                   
                   
                   
                 any amino acid residue, X 77  is any amino acid 
               
               
                   
                   
                   
                   
                 residue, X 78  is any amino acid residue, X 79  is any 
               
               
                   
                   
                   
                   
                 amino acid residue, X 81  is W, X 82  is any amino acid 
               
               
                   
                   
                   
                   
                 residue 
               
               
                   
                   
                   
                   
                 X 84  is any amino acid residue, and X 86  is any amino 
               
               
                   
                   
                   
                   
                 acid residue. 
               
               
                   
               
               
                 993 
                 PRT 
                 Artificial 
                 Luk26 
                 DSFX 32 IX 34 YX 36 EX 38 X 39 X 40 X 41 X 42 E 
               
               
                   
                   
                   
                 C strand/CD 
                 X 32  is any amino acid residue, X 34  is E, 
               
               
                   
                   
                   
                 loop region 
                 X 36  is any amino acid residue, X 38  is any amino 
               
               
                   
                   
                   
                 consensus 
                 acid residue, X 39  is W, X 40  is any amino acid 
               
               
                   
                   
                   
                   
                 residue, X 41  is W, X 42  is any amino acid residue. 
               
               
                   
               
               
                 994 
                 PRT 
                 Artificial 
                 Luk26 
                 TX 66 YX 68 VX 70 IX 72 GVKG X 77  X 78  X 79  SX 81   
               
               
                   
                   
                   
                 F strand and 
                 X 66  is any amino acid residue, X 68  is any amino 
               
               
                   
                   
                   
                 FG loop region 
                 acid residue, X 70  is F, X 72  is G, X 77  is any amino 
               
               
                   
                   
                   
                 consensus 
                 acid residue, X 78  is any amino acid residue, X 79  is 
               
               
                   
                   
                   
                   
                 any amino acid residue, X 81  is any amino acid 
               
               
                   
                   
                   
                   
                 residue. 
               
               
                   
               
               
                 995 
                 PRT 
                 Artificial 
                 Luk27 
                 DSFX 32 IX 34 YX 36 EX 38 X 39 X 40 X 41 GE 
               
               
                   
                   
                   
                 C strand/CD 
                 X 32  is any amino acid residue, X 34  is any amino 
               
               
                   
                   
                   
                 loop region 
                 acid residue, X 36  is any amino acid residue, X 38  is 
               
               
                   
                   
                   
                 consensus 
                 W, X 39  is any amino acid residue, X 40  is any amino 
               
               
                   
                   
                   
                   
                 acid residue, and X 41  is any amino acid residue; 
               
               
                   
               
               
                 996 
                 PRT 
                 Artificial 
                 Luk27 
                 TEYX 68 VX 70 IX 72 GVKGG X 78  X 79  SX 81   
               
               
                   
                   
                   
                 F strand and 
                 X 68  is L, X 70  is D, X 72  is Y, X 78  is any amino acid 
               
               
                   
                   
                   
                 FG loop region 
                 residue, X 79  is W, and X 81  is Y. 
               
               
                   
                   
                   
                 consensus 
                   
               
               
                   
               
               
                 997 
                 PRT 
                 Artificial 
                 Luk38 
                 X 75  X 76  X 77  X 78  X 79  X 80 X 81  X 82  X 83  X 84  X 85  X 86   
               
               
                   
                   
                   
                 FG loop region 
                 X 75  is any amino acid residue, X 76  is any amino 
               
               
                   
                   
                   
                 consensus 
                 acid residue, X 77  is I, X 78  is any amino acid 
               
               
                   
                   
                   
                   
                 residue, X 79  is any amino acid residue, X 80  is G, X 81   
               
               
                   
                   
                   
                   
                 is W, X 82  is L, X 83  is D, X 84  is F, X 85  is V, and X 86  is 
               
               
                   
                   
                   
                   
                 F. 
               
               
                   
               
               
                 998 
                 PRT 
                 Artificial 
                 Luk17 
                 DSFX 32 IX 34 YX 36 EX 38 X 39 X 40 X 41 X 42 E 
               
               
                   
                   
                   
                 C strand/CD 
                 X 32  is W, X 34  is any amino acid residue, X 36  is E, 
               
               
                   
                   
                   
                 loop region 
                 X 38  is K, X 39  is F, X 40  is Y, X 41  is R, and X 42  is any 
               
               
                   
                   
                   
                 consensus 
                 amino acid residue; 
               
               
                   
               
               
                 999 
                 PRT 
                 Artificial 
                 Luk17 
                 TX 66 YX 68 VX 70 IX 72 GVKG X 77  X 78  X 79  SX 81   
               
               
                   
                   
                   
                 F strand and 
                 X 66  is any amino acid residue, X 68  is K, X 70  is W, 
               
               
                   
                   
                   
                 FG loop region 
                 X 72  is any amino acid residue, X 77  is any amino 
               
               
                   
                   
                   
                 consensus 
                 acid residue, X 78  is any amino acid residue, X 79  is 
               
               
                   
                   
                   
                   
                 any amino acid residue, and X 81  is W. 
               
               
                   
               
               
                 1000 
                 PRT 
                 Human 
                 ProteinA3HC41 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNRF 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGK 
               
               
                   
               
               
                 1001 
                 PRT 
                 Human 
                 ProteinA3HC39 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPELLGGPSVFLFPPKPKDT 
               
               
                   
                   
                   
                   
                 LMISRTPEVTCVVVDVSHEDPEVKFNWYVD 
               
               
                   
                   
                   
                   
                 GVEVHNAKTKPREEQYNSTYRVVSVLTVLH 
               
               
                   
                   
                   
                   
                 QDWLNGKEYKCKVSNKALPAPIEKTISKAKG 
               
               
                   
                   
                   
                   
                 QPREPQVYTLPPSRDELTKNQVSLTCLVKGF 
               
               
                   
                   
                   
                   
                 YPSDIAVEWESNGQPENNYKTTPPVLDSDGS 
               
               
                   
                   
                   
                   
                 FFLYSKLTVDKSRWQQGNVFSCSVMHEALH 
               
               
                   
                   
                   
                   
                 NHYTQKSLSLSPGK 
               
               
                   
               
               
                 1002 
                 PRT 
                 Human 
                 ProteinA3HC40 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPPVAGPDVFLFPPKPKDTL 
               
               
                   
                   
                   
                   
                 MISRTPEVTCVVVDVSHEDPEVKFNWYVDG 
               
               
                   
                   
                   
                   
                 VEVHNAKTKPREEQYNSTYRVVSVLTVLHQ 
               
               
                   
                   
                   
                   
                 DWLNGKEYKCKVSNAALPAPIAKTISKAKGQ 
               
               
                   
                   
                   
                   
                 PREPQVYTLPPSRDELTKNQVSLTCLVKGFYP 
               
               
                   
                   
                   
                   
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
                   
                   
                   
                 YSKLTVDKSRWQQGNVFSCSVMHEALHNHY 
               
               
                   
                   
                   
                   
                 TQKSLSLSPGK 
               
               
                   
               
               
                 1003 
                 PRT 
                 Human 
                 PagibaximabHC68 
                 EVMLVESGGGLVQPKGSLKLSCAASGFTFNN 
               
               
                   
                   
                   
                   
                 YAMNWVRQAPGKGLEWVARIRSKSNNYAT 
               
               
                   
                   
                   
                   
                 FYADSVKDRFTISRDDSQSMLYLQMNNLKTE 
               
               
                   
                   
                   
                   
                 DTAMYYCVRRGASGIDYAMDYWGQGTSLT 
               
               
                   
                   
                   
                   
                 VSSASTKGPSVFPLAPSSKSTSGGTAALGCLV 
               
               
                   
                   
                   
                   
                 KDYFPEPVTVSWNSGALTSGVHTFPAVLQSS 
               
               
                   
                   
                   
                   
                 GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT 
               
               
                   
                   
                   
                   
                 KVDKKVEPKSCDKTHTCPPCPAPELLGGPSV 
               
               
                   
                   
                   
                   
                 FLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE 
               
               
                   
                   
                   
                   
                 VKFNWYVDGVEVHNAKTKPREEQYNSTYR 
               
               
                   
                   
                   
                   
                 VVSVLTVLHQDWLNGKEYKCKVSNKALPAP 
               
               
                   
                   
                   
                   
                 IEKTISKAKGQPREPQVYTLPPSRDELTKNQV 
               
               
                   
                   
                   
                   
                 SLTCLVKGFYPSDIAVEWESNGQPENNYKTT 
               
               
                   
                   
                   
                   
                 PPVLDSDGSFFLYSKLTVDKSRWQQGNVFSC 
               
               
                   
                   
                   
                   
                 SVMHEALHNHYTQKSLSLSPGK 
               
               
                   
               
               
                 1004 
                 PRT 
                 Human 
                 PagibaximabHC23 
                 EVMLVESGGGLVQPKGSLKLSCAASGFTFNN 
               
               
                   
                   
                   
                   
                 YAMNWVRQAPGKGLEWVARIRSKSNNYAT 
               
               
                   
                   
                   
                   
                 FYADSVKDRFTISRDDSQSMLYLQMNNLKTE 
               
               
                   
                   
                   
                   
                 DTAMYYCVRRGASGIDYAMDYWGQGTSLT 
               
               
                   
                   
                   
                   
                 VSSASTKGPSVFPLAPSSKSTSGGTAALGCLV 
               
               
                   
                   
                   
                   
                 KDYFPEPVTVSWNSGALTSGVHTFPAVLQSS 
               
               
                   
                   
                   
                   
                 GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT 
               
               
                   
                   
                   
                   
                 KVDKKVEPKSCDKTHTCPPCPAPPVAGPDVF 
               
               
                   
                   
                   
                   
                 LFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV 
               
               
                   
                   
                   
                   
                 KFNWYVDGVEVHNAKTKPREEQYNSTYRV 
               
               
                   
                   
                   
                   
                 VSVLTVLHQDWLNGKEYKCKVSNAALPAPI 
               
               
                   
                   
                   
                   
                 AKTISKAKGQPREPQVYTLPPSRDELTKNQVS 
               
               
                   
                   
                   
                   
                 LTCLVKGFYPSDIAVEWESNGQPENNYKTTP 
               
               
                   
                   
                   
                   
                 PVLDSDGSFFLYSKLTVDKSRWQQGNVFSCS 
               
               
                   
                   
                   
                   
                 VMHEALHNRFTQKSLSLSPGK 
               
               
                   
               
               
                 1005 
                 PRT 
                 Human 
                 PagibaximabHC69 
                 EVMLVESGGGLVQPKGSLKLSCAASGFTFNN 
               
               
                   
                   
                   
                   
                 YAMNWVRQAPGKGLEWVARIRSKSNNYAT 
               
               
                   
                   
                   
                   
                 FYADSVKDRFTISRDDSQSMLYLQMNNLKTE 
               
               
                   
                   
                   
                   
                 DTAMYYCVRRGASGIDYAMDYWGQGTSLT 
               
               
                   
                   
                   
                   
                 VSSASTKGPSVFPLAPSSKSTSGGTAALGCLV 
               
               
                   
                   
                   
                   
                 KDYFPEPVTVSWNSGALTSGVHTFPAVLQSS 
               
               
                   
                   
                   
                   
                 GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT 
               
               
                   
                   
                   
                   
                 KVDKKVEPKSCDKTHTCPPCPAPPVAGPDVF 
               
               
                   
                   
                   
                   
                 LFPPKPKDTLMISRTPEVTCVVVDVSHEDPEV 
               
               
                   
                   
                   
                   
                 KFNWYVDGVEVHNAKTKPREEQYNSTYRV 
               
               
                   
                   
                   
                   
                 VSVLTVLHQDWLNGKEYKCKVSNAALPAPI 
               
               
                   
                   
                   
                   
                 AKTISKAKGQPREPQVYTLPPSRDELTKNQVS 
               
               
                   
                   
                   
                   
                 LTCLVKGFYPSDIAVEWESNGQPENNYKTTP 
               
               
                   
                   
                   
                   
                 PVLDSDGSFFLYSKLTVDKSRWQQGNVFSCS 
               
               
                   
                   
                   
                   
                 VMHEALHNHYTQKSLSLSPGK 
               
               
                   
               
               
                 1006 
                 PRT 
                 Human 
                 PagibaximabHC686 
                 EVMLVESGGGLVQPKGSLKLSCAASGFTFNN 
               
               
                   
                   
                   
                   
                 YAMNWVRQAPGKGLEWVARIRSKSNNYAT 
               
               
                   
                   
                   
                   
                 FYADSVKDRFTISRDDSQSMLYLQMNNLKTE 
               
               
                   
                   
                   
                   
                 DTAMYYCVRRGASGIDYAMDYWGQGTSLT 
               
               
                   
                   
                   
                   
                 VSSASTKGPSVFPLAPSSKSTSGGTAALGCLV 
               
               
                   
                   
                   
                   
                 KDYFPEPVTVSWNSGALTSGVHTFPAVLQSS 
               
               
                   
                   
                   
                   
                 GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT 
               
               
                   
                   
                   
                   
                 KVDKKVEPKSCDKTHTCPPCPAPELLGGPSV 
               
               
                   
                   
                   
                   
                 FLFPPKPKDTLMISRTPEVTCVVVDVSHEDPE 
               
               
                   
                   
                   
                   
                 VKFNWYVDGVEVHNAKTKPREEQYNSTYR 
               
               
                   
                   
                   
                   
                 VVSVLTVLHQDWLNGKEYKCKVSNKALPAP 
               
               
                   
                   
                   
                   
                 IEKTISKAKGQPREPQVYTLPPSRDELTKNQV 
               
               
                   
                   
                   
                   
                 SLTCLVKGFYPSDIAVEWESNGQPENNYKTT 
               
               
                   
                   
                   
                   
                 PPVLDSDGSFFLYSKLTVDKSRWQQGNVFSC 
               
               
                   
                   
                   
                   
                 SVMHEALHNRFTQKSLSLSPGK 
               
               
                   
               
               
                 1007 
                 PRT 
                 Human 
                 ProteinA5HC42 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGGIIPIFGTANYAQ 
               
               
                   
                   
                   
                   
                 KFQGRVTITADESTSTAYMELSSLRSEDTAVY 
               
               
                   
                   
                   
                   
                 YCARTELRASWGDFDYWGQGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPELLGGPSVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNKALPAPIEKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNHYTQKSLSLSPGK 
               
               
                   
               
               
                 1008 
                 PRT 
                 Human 
                 ProteinA5HC43 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGGIIPIFGTANYAQ 
               
               
                   
                   
                   
                   
                 KFQGRVTITADESTSTAYMELSSLRSEDTAVY 
               
               
                   
                   
                   
                   
                 YCARTELRASWGDFDYWGQGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNHYTQKSLSLSPGK 
               
               
                   
               
               
                 1009 
                 PRT 
                 Human 
                 ProteinAA5HC44 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGGIIPIFGTANYAQ 
               
               
                   
                   
                   
                   
                 KFQGRVTITADESTSTAYMELSSLRSEDTAVY 
               
               
                   
                   
                   
                   
                 YCARTELRASWGDFDYWGQGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGK 
               
               
                   
               
               
                 1010 
                 PRT 
                 Human 
                 ProteinA5HC45 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGGIIPIFGTANYAQ 
               
               
                   
                   
                   
                   
                 KFQGRVTITADESTSTAYMELSSLRSEDTAVY 
               
               
                   
                   
                   
                   
                 YCARTELRASWGDFDYWGQGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPELLGGPSVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNKALPAPIEKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGK 
               
               
                   
               
               
                 1011 
                 PRT 
                 Human 
                 ProteinA3HC46 
                 QVQLVQSGAEVKKPGSSVKVSCKASGGTFSS 
               
               
                   
                   
                   
                   
                 YAISWVRQAPGQGLEWMGWISAINGNTNYA 
               
               
                   
                   
                   
                   
                 QKFQGRVTITADESTSTAYMELSSLRSEDTAV 
               
               
                   
                   
                   
                   
                 YYCARIWNFLLDYWGQGTLVTVSSASTKGPS 
               
               
                   
                   
                   
                   
                 VFPLAPSSKSTSGGTAALGCLVKDYFPEPVTV 
               
               
                   
                   
                   
                   
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVT 
               
               
                   
                   
                   
                   
                 VPSSSLGTQTYICNVNHKPSNTKVDKKVEPK 
               
               
                   
                   
                   
                   
                 SCDKTHTCPPCPAPELLGGPSVFLFPPKPKDT 
               
               
                   
                   
                   
                   
                 LMISRTPEVTCVVVDVSHEDPEVKFNWYVD 
               
               
                   
                   
                   
                   
                 GVEVHNAKTKPREEQYNSTYRVVSVLTVLH 
               
               
                   
                   
                   
                   
                 QDWLNGKEYKCKVSNKALPAPIEKTISKAKG 
               
               
                   
                   
                   
                   
                 QPREPQVYTLPPSRDELTKNQVSLTCLVKGF 
               
               
                   
                   
                   
                   
                 YPSDIAVEWESNGQPENNYKTTPPVLDSDGS 
               
               
                   
                   
                   
                   
                 FFLYSKLTVDKSRWQQGNVFSCSVMHEALH 
               
               
                   
                   
                   
                   
                 NRFTQKSLSLSPGK 
               
               
                   
               
               
                 1012 
                 PRT 
                 Human 
                 ProteinAA9HC47 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPELLGGPSVFLFPP 
               
               
                   
                   
                   
                   
                 KPKDTLMISRTPEVTCVVVDVSHEDPEVKFN 
               
               
                   
                   
                   
                   
                 WYVDGVEVHNAKTKPREEQYNSTYRVVSVL 
               
               
                   
                   
                   
                   
                 TVLHQDWLNGKEYKCKVSNKALPAPIEKTIS 
               
               
                   
                   
                   
                   
                 KAKGQPREPQVYTLPPSRDELTKNQVSLTCL 
               
               
                   
                   
                   
                   
                 VKGFYPSDIAVEWESNGQPENNYKTTPPVLD 
               
               
                   
                   
                   
                   
                 SDGSFFLYSKLTVDKSRWQQGNVFSCSVMH 
               
               
                   
                   
                   
                   
                 EALHNHYTQKSLSLSPGK 
               
               
                   
               
               
                 1013 
                 PRT 
                 Human 
                 ProteinA9HC48 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPELLGGPSVFLFPP 
               
               
                   
                   
                   
                   
                 KPKDTLMISRTPEVTCVVVDVSHEDPEVKFN 
               
               
                   
                   
                   
                   
                 WYVDGVEVHNAKTKPREEQYNSTYRVVSVL 
               
               
                   
                   
                   
                   
                 TVLHQDWLNGKEYKCKVSNKALPAPIEKTIS 
               
               
                   
                   
                   
                   
                 KAKGQPREPQVYTLPPSRDELTKNQVSLTCL 
               
               
                   
                   
                   
                   
                 VKGFYPSDIAVEWESNGQPENNYKTTPPVLD 
               
               
                   
                   
                   
                   
                 SDGSFFLYSKLTVDKSRWQQGNVFSCSVMH 
               
               
                   
                   
                   
                   
                 EALHNRFTQKSLSLSPGK 
               
               
                   
               
               
                 1014 
                 PRT 
                 Human 
                 ProteinA9HC49 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNHYTQKSLSLSPGK 
               
               
                   
               
               
                 1015 
                 PRT 
                 Human 
                 ProteinA9HC50 
                 EVQLVQSGAEVKKPGESLKISCKGSGYSFTSY 
               
               
                   
                   
                   
                   
                 WIGWVRQMPGKGLEWMGIIYPGDSDTRYSP 
               
               
                   
                   
                   
                   
                 SFQGQVTISADKSISTAYLQWSSLKASDTAM 
               
               
                   
                   
                   
                   
                 YYCARWSYSQYSGWLDYWGQGTLVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGK 
               
               
                   
               
               
                 1016 
                 PRT 
                 Human 
                 ProteinA5LC 
                 DIQMTQSPSSLSASVGDRVTITCRASQSISSYL 
               
               
                   
                   
                   
                   
                 NWYQQKPGKAPKLLIYAASSLQSGVPSRFSG 
               
               
                   
                   
                   
                   
                 SGSGTDFTLTISSLQPEDFATYYCQQSYSTPLT 
               
               
                   
                   
                   
                   
                 FGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGT 
               
               
                   
                   
                   
                   
                 ASVVCLLNNFYPREAKVQWKVDNALQSGNS 
               
               
                   
                   
                   
                   
                 QESVTEQDSKDSTYSLSSTLTLSKADYEKHK 
               
               
                   
                   
                   
                   
                 VYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 1017 
                 PRT 
                 Artificial 
                 Tencon 
                 LPAPKNLVVSEVTEDSLRLSWTAPDAAFDSF 
               
               
                   
                   
                   
                   
                 LIQYQESEKVGEAINLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYTVSIYGVKGGHRSNPLSAEFTT 
               
               
                   
               
               
                 1018 
                 PRT 
                 Artificial 
                 LukA (PDB 
                 NSAHKDSQDQNKKEHVDKSQQKDKRNVTN 
               
               
                   
                   
                   
                 Entry 4tw1) 
                 KDKNSTAPDDIGKNGKITKRTETVYDEKTNIL 
               
               
                   
                   
                   
                   
                 QNLQFDFIDDPTYDKNVLLVKKQGSIHSNLK 
               
               
                   
                   
                   
                   
                 FESHKEEKNSNWLKYPSEYHVDFQVKRNRK 
               
               
                   
                   
                   
                   
                 TEILDQLPKNKISTAKVDSTFSYSSGGKFDST 
               
               
                   
                   
                   
                   
                 KGIGRTSSNSYSKTISYNQQNYDTIASGKNNN 
               
               
                   
                   
                   
                   
                 WHVHWSVIANDLKYGGEVKNRNDELLFYR 
               
               
                   
                   
                   
                   
                 NTRIATVENPELSFASKYRYPALVRSGFNPEF 
               
               
                   
                   
                   
                   
                 LTYLSNEKSNEKTQFEVTYTRNQDILKNRPGI 
               
               
                   
                   
                   
                   
                 HYAPPILEKNKDGQRLIVTYEVDWKNKTVK 
               
               
                   
                   
                   
                   
                 VVDKYSDDNKPYKEG 
               
               
                   
               
               
                 1019 
                 PRT 
                 Artificial 
                 LukA (HDX) 
                 NSAHHHHHHGSHKDSQDQNKKEHVDKSQQ 
               
               
                   
                   
                   
                   
                 KDKRNVTNKDKNSTAPDDIGKNGKITKRTET 
               
               
                   
                   
                   
                   
                 VYDEKTNILQNLQFDFIDDPTYDKNVLLVKK 
               
               
                   
                   
                   
                   
                 QGSIHSNLKFESHKEEKNSNWLKYPSEYHVD 
               
               
                   
                   
                   
                   
                 FQVKRNRKTEILDQLPKNKISTAKVDSTFSYS 
               
               
                   
                   
                   
                   
                 SGGKFDSTKGIGRTSSNSYSKTISYNQQNYDT 
               
               
                   
                   
                   
                   
                 IASGKNNNWHVHWSVIANDLKYGGEVKNR 
               
               
                   
                   
                   
                   
                 NDELLFYRNTRIATVENPELSFASKYRYPALV 
               
               
                   
                   
                   
                   
                 RSGFNPEFLTYLSNEKSNEKTQFEVTYTRNQ 
               
               
                   
                   
                   
                   
                 DILKNRPGIHYAPPILEKNKDGQRLIVTYEVD 
               
               
                   
                   
                   
                   
                 WKNKTVKVVDKYSDDNKPYKAG 
               
               
                   
               
               
                 1020 
                 PRT 
                 Artificial 
                 LukA (Loop 
                 MNSAHHHHHHGSHKDSQDQNKKEHVDKSQ 
               
               
                   
                   
                   
                 Mutants) 
                 QKDKRNVTNKDKNSTAPDDIGKNGKITKRTE 
               
               
                   
                   
                   
                   
                 TVYDEKTNILQNLQFDFIDDPTYDKNVLLVK 
               
               
                   
                   
                   
                   
                 KQGSIHSNLKFESHKEEKNSNWLKYPSEYHV 
               
               
                   
                   
                   
                   
                 DFQVKRNRKTEILDQLPKNKISTAKVDSTFSY 
               
               
                   
                   
                   
                   
                 SSGGKFDSTKGIGRTSSNSYSKTISYNQQNYD 
               
               
                   
                   
                   
                   
                 TIASGKNNNWHVHWSVIANDLKYGGEVKNR 
               
               
                   
                   
                   
                   
                 NDELLFYRNTRIATVENPELSFASKYRYPALV 
               
               
                   
                   
                   
                   
                 RSGFNPEFLTYLSNEKSNEKTQFEVTYTRNQ 
               
               
                   
                   
                   
                   
                 DILKNRPGIHYAPPILEKNKDGQRLIVTYEVD 
               
               
                   
                   
                   
                   
                 WKNKTVKVVDKYSDDNKPYKAG 
               
               
                   
               
               
                 1021 
                 PRT 
                 Artificial 
                 LukA (Point 
                 MNSAHHHHHHHHHHGGGLNDIFEAQKIEWH 
               
               
                   
                   
                   
                 Mutants) 
                 EGSHKDSQDQNKKEHVDKSQQKDKRNVTN 
               
               
                   
                   
                   
                   
                 KDKNSTAPDDIGKNGKITKRTETVYDEKTNIL 
               
               
                   
                   
                   
                   
                 QNLQFDFIDDPTYDKNVLLVKKQGSIHSNLK 
               
               
                   
                   
                   
                   
                 FESHKEEKNSNWLKYPSEYHVDFQVKRNRK 
               
               
                   
                   
                   
                   
                 TEILDQLPKNKISTAKVDSTFSYSSGGKFDST 
               
               
                   
                   
                   
                   
                 KGIGRTSSNSYSKTISYNQQNYDTIASGKNNN 
               
               
                   
                   
                   
                   
                 WHVHWSVIANDLKYGGEVKNRNDELLFYR 
               
               
                   
                   
                   
                   
                 NTRIATVENPELSFASKYRYPALVRSGFNPEF 
               
               
                   
                   
                   
                   
                 LTYLSNEKSNEKTQFEVTYTRNQDILKNRPGI 
               
               
                   
                   
                   
                   
                 HYAPPILEKNKDGQRLIVTYEVDWKNKTVK 
               
               
                   
                   
                   
                   
                 VVDKYSDDNKPYKAG 
               
               
                   
               
               
                 1022 
                 PRT 
                 Artificial 
                 LukA mut3 
                 MNSAHHHHHHGSHKDSQDQNKKEHVDKSQ 
               
               
                   
                   
                   
                   
                 QKDKRNVTNKDKNSTAPDDIGKNGKITKRTE 
               
               
                   
                   
                   
                   
                 TVYDEKTNILQNLQFDFIDDPTYDKNVLLVK 
               
               
                   
                   
                   
                   
                 KQGSIHSNLKFESHKEEKNSNWLKYPSEYHV 
               
               
                   
                   
                   
                   
                 DFQVKRNRKTEILDQLPKNKISGGSGGNYDTI 
               
               
                   
                   
                   
                   
                 ASGKNNNWHVHWSVIANDLKYGGEVKNRN 
               
               
                   
                   
                   
                   
                 DELLFYRNTRIATVENPELSFASKYRYPALVR 
               
               
                   
                   
                   
                   
                 SGFNPEFLTYLSNEKSNEKTQFEVTYTRNQDI 
               
               
                   
                   
                   
                   
                 LKNRPGIHYAPPILEKNKDGQRLIVTYEVDW 
               
               
                   
                   
                   
                   
                 KNKTVKVVDKYSDDNKPYKAG 
               
               
                   
               
               
                 1023 
                 PRT 
                 Artificial 
                 LukA mut4 
                 MNSAHHHHHHGSHKDSQDQNKKEHVDKSQ 
               
               
                   
                   
                   
                   
                 QKDKRNVTNKDKNSTAPDDIGKNGKITKRTE 
               
               
                   
                   
                   
                   
                 TVYDEKTNILQNLQFDFIDDPTYDKNVLLVK 
               
               
                   
                   
                   
                   
                 KQGSIHSNLKFESHKEEKNSNWLKYPSEYHV 
               
               
                   
                   
                   
                   
                 DFQVKRNRKTEILDQLPKNKISGGSGNYDTIA 
               
               
                   
                   
                   
                   
                 SGKNNNWHVHWSVIANDLKYGGEVKNRND 
               
               
                   
                   
                   
                   
                 ELLFYRNTRIATVENPELSFASKYRYPALVRS 
               
               
                   
                   
                   
                   
                 GFNPEFLTYLSNEKSNEKTQFEVTYTRNQDIL 
               
               
                   
                   
                   
                   
                 KNRPGIHYAPPILEKNKDGQRLIVTYEVDWK 
               
               
                   
                   
                   
                   
                 NKTVKVVDKYSDDNKPYKAG 
               
               
                   
               
               
                 1024 
                 PRT 
                 Artificial 
                 LukA mut5 
                 MNSAHHHHHHGSHKDSQDQNKKEHVDKSQ 
               
               
                   
                   
                   
                   
                 QKDKRNVTNKDKNSTAPDDIGKNGKITKRTE 
               
               
                   
                   
                   
                   
                 TVYDEKTNILQNLQFDFIDDPTYDKNVLLVK 
               
               
                   
                   
                   
                   
                 KQGSIHSNLKFESHKEEKNSNWLKYPSEYHV 
               
               
                   
                   
                   
                   
                 DFQVKRNRKTEILDQLPKNSGGSGQNYDTIA 
               
               
                   
                   
                   
                   
                 SGKNNNWHVHWSVIANDLKYGGEVKNRND 
               
               
                   
                   
                   
                   
                 ELLFYRNTRIATVENPELSFASKYRYPALVRS 
               
               
                   
                   
                   
                   
                 GFNPEFLTYLSNEKSNEKTQFEVTYTRNQDIL 
               
               
                   
                   
                   
                   
                 KNRPGIHYAPPILEKNKDGQRLIVTYEVDWK 
               
               
                   
                   
                   
                   
                 NKTVKVVDKYSDDNKPYKAG 
               
               
                   
               
               
                 1025 
                 PRT 
                 Artificial 
                 LukA mut6 
                 MNSAHHHHHHGSHKDSQDQNKKEHVDKSQ 
               
               
                   
                   
                   
                   
                 QKDKRNVTNKDKNSTAPDDIGKNGKITKRTE 
               
               
                   
                   
                   
                   
                 TVYDEKTNILQNLQFDFIDDPTYDKNVLLVK 
               
               
                   
                   
                   
                   
                 KQGSIHSNLKFESHKEEKNSNWLKYPSEYHV 
               
               
                   
                   
                   
                   
                 DFQVKRNRKTEILDQLPKNSGGSGGQNYDTI 
               
               
                   
                   
                   
                   
                 ASGKNNNWHVHWSVIANDLKYGGEVKNRN 
               
               
                   
                   
                   
                   
                 DELLFYRNTRIATVENPELSFASKYRYPALVR 
               
               
                   
                   
                   
                   
                 SGFNPEFLTYLSNEKSNEKTQFEVTYTRNQDI 
               
               
                   
                   
                   
                   
                 LKNRPGIHYAPPILEKNKDGQRLIVTYEVDW 
               
               
                   
                   
                   
                   
                 KNKTVKVVDKYSDDNKPYKAG 
               
               
                   
               
               
                 1026 
                 PRT 
                 Artificial 
                 LukB (PDB 
                 KINSEIKQVSEKNLDGDTKMYTRTATTSDSQ 
               
               
                   
                   
                   
                 Entry 4tw1) 
                 KNITQSLQFNFLTEPNYDKETVFIKAKGTIGS 
               
               
                   
                   
                   
                   
                 GLRILDPNGYWNSTLRWPGSYSVSIQNVDDN 
               
               
                   
                   
                   
                   
                 NNTNVTDFAPKNQDESREVKYTYGYKTGGD 
               
               
                   
                   
                   
                   
                 FSINRGGLTGNITKESNYSETISYQQPSYRTLL 
               
               
                   
                   
                   
                   
                 DQSTSHKGVGWKVEAHLINNMGHDHTRQLT 
               
               
                   
                   
                   
                   
                 NDSDNRTKSEIFSLTRNGNLWAKDNFTPKDK 
               
               
                   
                   
                   
                   
                 MPVTVSEGFNPEFLAVMSHDKKDKGKSQFV 
               
               
                   
                   
                   
                   
                 VHYKRSMDEFKIDWNRHGFWGYWSGENHV 
               
               
                   
                   
                   
                   
                 DKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
               
               
                 1027 
                 PRT 
                 Artificial 
                 LukB (HDX) 
                 KINSEIKQVSEKNLDGDTKMYTRTATTSDSQ 
               
               
                   
                   
                   
                   
                 KNITQSLQFNFLTEPNYDKETVFIKAKGTIGS 
               
               
                   
                   
                   
                   
                 GLRILDPNGYWNSTLRWPGSYSVSIQNVDDN 
               
               
                   
                   
                   
                   
                 NNTNVTDFAPKNQDESREVKYTYGYKTGGD 
               
               
                   
                   
                   
                   
                 FSINRGGLTGNITKESNYSETISYQQPSYRTLL 
               
               
                   
                   
                   
                   
                 DQSTSHKGVGWKVEAHLINNMGHDHTRQLT 
               
               
                   
                   
                   
                   
                 NDSDNRTKSEIFSLTRNGNLWAKDNFTPKDK 
               
               
                   
                   
                   
                   
                 MPVTVSEGFNPEFLAVMSHDKKDKGKSQFV 
               
               
                   
                   
                   
                   
                 VHYKRSMDEFKIDWNRHGFWGYWSGENHV 
               
               
                   
                   
                   
                   
                 DKKEEKLSALYEVDWKTHNVKFVKVLNDNE 
               
               
                   
                   
                   
                   
                 KK 
               
               
                   
               
               
                 1028 
                 PRT 
                 Artificial 
                 LukB 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                 (Mutants) 
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRNGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWNRHGFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1029 
                 PRT 
                 Artificial 
                 LukB mut3 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESGGSGGSYRTLLDQS 
               
               
                   
                   
                   
                   
                 TSHKGVGWKVEAHLINNMGHDHTRQLTNDS 
               
               
                   
                   
                   
                   
                 DNRTKSEIFSLTRNGNLWAKDNFTPKDKMPV 
               
               
                   
                   
                   
                   
                 TVSEGFNPEFLAVMSHDKKDKGKSQFVVHY 
               
               
                   
                   
                   
                   
                 KRSMDEFKIDWNRHGFWGYWSGENHVDKK 
               
               
                   
                   
                   
                   
                 EEKLSALYEVDWKTHNVKFVKVLNDNEKK 
               
               
                   
               
               
                 1030 
                 PRT 
                 Artificial 
                 LukB mut4 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESGGSGSYRTLLDQST 
               
               
                   
                   
                   
                   
                 SHKGVGWKVEAHLINNMGHDHTRQLTNDS 
               
               
                   
                   
                   
                   
                 DNRTKSEIFSLTRNGNLWAKDNFTPKDKMPV 
               
               
                   
                   
                   
                   
                 TVSEGFNPEFLAVMSHDKKDKGKSQFVVHY 
               
               
                   
                   
                   
                   
                 KRSMDEFKIDWNRHGFWGYWSGENHVDKK 
               
               
                   
                   
                   
                   
                 EEKLSALYEVDWKTHNVKFVKVLNDNEKK 
               
               
                   
               
               
                 1031 
                 PRT 
                 Artificial 
                 LukB mut5 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESGGSGPSYRTLLDQS 
               
               
                   
                   
                   
                   
                 TSHKGVGWKVEAHLINNMGHDHTRQLTNDS 
               
               
                   
                   
                   
                   
                 DNRTKSEIFSLTRNGNLWAKDNFTPKDKMPV 
               
               
                   
                   
                   
                   
                 TVSEGFNPEFLAVMSHDKKDKGKSQFVVHY 
               
               
                   
                   
                   
                   
                 KRSMDEFKIDWNRHGFWGYWSGENHVDKK 
               
               
                   
                   
                   
                   
                 EEKLSALYEVDWKTHNVKFVKVLNDNEKK 
               
               
                   
               
               
                 1032 
                 PRT 
                 Artificial 
                 LukB mut6 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQSGGSGPSYRTLLDQSTS 
               
               
                   
                   
                   
                   
                 HKGVGWKVEAHLINNMGHDHTRQLTNDSD 
               
               
                   
                   
                   
                   
                 NRTKSEIFSLTRNGNLWAKDNFTPKDKMPVT 
               
               
                   
                   
                   
                   
                 VSEGFNPEFLAVMSHDKKDKGKSQFVVHYK 
               
               
                   
                   
                   
                   
                 RSMDEFKIDWNRHGFWGYWSGENHVDKKE 
               
               
                   
                   
                   
                   
                 EKLSALYEVDWKTHNVKFVKVLNDNEKK 
               
               
                   
               
               
                 1033 
                 PRT 
                 Artificial 
                 LukB_Y74A 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGAWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRNGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWNRHGFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1034 
                 PRT 
                 Artificial 
                 LukB_W75A 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYANSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRNGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWNRHGFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1035 
                 PRT 
                 Artificial 
                 LukB_R194A 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNATKSEIFSLTRNGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWNRHGFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1036 
                 PRT 
                 Artificial 
                 LukB_K196A 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTASEIFSLTRNGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWNRHGFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1037 
                 PRT 
                 Artificial 
                 LukB_R204A 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTANGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWNRHGFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1038 
                 PRT 
                 Artificial 
                 LukB_N205A 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRAGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWNRHGFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1039 
                 PRT 
                 Artificial 
                 LukB_N207A 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRNGALWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWNRHGFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1040 
                 PRT 
                 Artificial 
                 LukB_W209A 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRNGNLAAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWNRHGFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1041 
                 PRT 
                 Artificial 
                 LukB_D262A 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRNGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIAWNRHGFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1042 
                 PRT 
                 Artificial 
                 LukB_D262R 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRNGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIRWNRHGFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1043 
                 PRT 
                 Artificial 
                 LukB_W263A 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRNGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDANRHGFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1044 
                 PRT 
                 Artificial 
                 LukB_N264A 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRNGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWARHGFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1045 
                 PRT 
                 Artificial 
                 LukB_R265A 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRNGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWNAHGFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1046 
                 PRT 
                 Artificial 
                 LukB_R265E 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRNGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWNEHGFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1047 
                 PRT 
                 Artificial 
                 LukB_H266A 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRNGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWNRAGFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1048 
                 PRT 
                 Artificial 
                 LukB_G267R 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRNGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWNRHRFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1049 
                 PRT 
                 Artificial 
                 LukB_G267A 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRNGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWNRHAFWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1050 
                 PRT 
                 Artificial 
                 LukB_F268A 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRNGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWNRHGAWGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1051 
                 PRT 
                 Artificial 
                 LukB_W269A 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRNGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWNRHGFAGYWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1052 
                 PRT 
                 Artificial 
                 LukB_Y271A 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRGGLTGNITKESNYSETISYQQPSYRTL 
               
               
                   
                   
                   
                   
                 LDQSTSHKGVGWKVEAHLINNMGHDHTRQL 
               
               
                   
                   
                   
                   
                 TNDSDNRTKSEIFSLTRNGNLWAKDNFTPKD 
               
               
                   
                   
                   
                   
                 KMPVTVSEGFNPEFLAVMSHDKKDKGKSQF 
               
               
                   
                   
                   
                   
                 VVHYKRSMDEFKIDWNRHGFWGAWSGENH 
               
               
                   
                   
                   
                   
                 VDKKEEKLSALYEVDWKTHNVKFVKVLND 
               
               
                   
                   
                   
                   
                 NEKK 
               
               
                   
               
               
                 1053 
                 PRT 
                 Artificial 
                 Luk17 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FWITYEEKFYRGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYKVWIVGVKGGQGSWPLSAIFTTGGHH 
               
               
                   
                   
                   
                   
                 HHHH 
               
               
                   
               
               
                 1054 
                 PRT 
                 Artificial 
                 LukE (PDB 
                 MFKKKMLAATLSVGLIAPLASPIQESRANTNI 
               
               
                   
                   
                   
                 Entry 3rohA) 
                 ENIGDGAEVIKRTEDVSSKKWGVTQNVQFDF 
               
               
                   
                   
                   
                   
                 VKDKKYNKDALIVKMQGFINSRTSFSDVKGS 
               
               
                   
                   
                   
                   
                 GYELTKRMIWPFQYNIGLTTKDPNVSLINYLP 
               
               
                   
                   
                   
                   
                 KNKIETTDVGQTLGYNIGGNFQSAPSIGGNGS 
               
               
                   
                   
                   
                   
                 FNYSKTISYTQKSYVSEVDKQNSKSVKWGV 
               
               
                   
                   
                   
                   
                 KANEFVTPDGKKSAHDRYLFVQSPNGPTGSA 
               
               
                   
                   
                   
                   
                 REYFAPDNQLPPLVQSGFNPSFITTLSHEKGSS 
               
               
                   
                   
                   
                   
                 DTSEFEISYGRNLDITYATLFPRTGIYAERKHN 
               
               
                   
                   
                   
                   
                 AFVNRNFVVRYEVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1055 
                 PRT 
                 Artificial 
                 LukE (HDX) 
                 NSAHHHHHHGSNTNIENIGDGAEVIKRTEDV 
               
               
                   
                   
                   
                   
                 SSKKWGVTQNVQFDFVKDKKYNKDALIVK 
               
               
                   
                   
                   
                   
                 MQGFINSRTSFSDVKGSGYELTKRMIWPFQY 
               
               
                   
                   
                   
                   
                 NIGLTTKDPNVSLINYLPKNKIETTDVGQTLG 
               
               
                   
                   
                   
                   
                 YNIGGNFQSAPSIGGNGSFNYSKTISYTQKSY 
               
               
                   
                   
                   
                   
                 VSEVDKQNSKSVKWGVKANEFVTPDGKKSA 
               
               
                   
                   
                   
                   
                 HDRYLFVQSPNGPTGSAREYFAPDNQLPPLV 
               
               
                   
                   
                   
                   
                 QSGFNPSFITTLSHEKGSSDTSEFELSYGRNLD 
               
               
                   
                   
                   
                   
                 ITYATLFPRTGIYAERKHNAFVNRNFVVRYK 
               
               
                   
                   
                   
                   
                 VNWKTHEIKVKGHN 
               
               
                   
               
               
                 1056 
                 PRT 
                 Artificial 
                 LukE 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                 (Mutants) 
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKGSGYELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLFPRTGIYAERKHNAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1057 
                 PRT 
                 Artificial 
                 LukE_S105A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFADVKGSGYELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLFPRTGIYAERKHNAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1058 
                 PRT 
                 Artificial 
                 LukE_V107A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDAKGSGYELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLFPRTGIYAERKHNAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1059 
                 PRT 
                 Artificial 
                 LukE_K108A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVAGSGYELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLFPRTGIYAERKHNAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1060 
                 PRT 
                 Artificial 
                 LukE_G109R 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKRSGYELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLFPRTGIYAERKHNAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1061 
                 PRT 
                 Artificial 
                 LukE_Y112A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKGSGAELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLFPRTGIYAERKHNAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1062 
                 PRT 
                 Artificial 
                 LukE_L114A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKGSGYEATKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLFPRTGIYAERKHNAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1063 
                 PRT 
                 Artificial 
                 LukE_T115A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKGSGYELAKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLFPRTGIYAERKHNAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1064 
                 PRT 
                 Artificial 
                 LukE_R117A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKGSGYELTKAMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLFPRTGIYAERKHNAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1065 
                 PRT 
                 Artificial 
                 LukE_I283A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKGSGYELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DATYATLFPRTGIYAERKHNAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1066 
                 PRT 
                 Artificial 
                 LukE_Y285A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKGSGYELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITAATLFPRTGIYAERKHNAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1067 
                 PRT 
                 Artificial 
                 LukE_T287A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKGSGYELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYAALFPRTGIYAERKHNAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1068 
                 PRT 
                 Artificial 
                 LukE_F289A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKGSGYELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLAPRTGIYAERKHNAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1069 
                 PRT 
                 Artificial 
                 LukE_T292A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKGSGYELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLFPRAGIYAERKHNAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1070 
                 PRT 
                 Artificial 
                 LukE_Y295A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKGSGYELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLFPRTGIAAERKHNAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1071 
                 PRT 
                 Artificial 
                 LukE_E297A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKGSGYELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLFPRTGIYAARKHNAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1072 
                 PRT 
                 Artificial 
                 LukE_K299A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKGSGYELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLFPRTGIYAERAHNAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1073 
                 PRT 
                 Artificial 
                 LukE_H300A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKGSGYELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLFPRTGIYAERKANAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1074 
                 PRT 
                 Artificial 
                 LukE_N301A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKGSGYELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLFPRTGIYAERKHAAFVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1075 
                 PRT 
                 Artificial 
                 LukE_F303A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKGSGYELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLFPRTGIYAERKHNAAVNRNFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1076 
                 PRT 
                 Artificial 
                 LukE_R306A 
                 MGSSGLNDIFEAQKIEWHEGGHHHHHHHHH 
               
               
                   
                   
                   
                   
                 HSSGLVPRGSHMLENTNIENIGDGAEVIKRTE 
               
               
                   
                   
                   
                   
                 DVSSKKWGVTQNVQFDFVKDKKYNKDALIV 
               
               
                   
                   
                   
                   
                 KMQGFINSRTSFSDVKGSGYELTKRMIWPFQ 
               
               
                   
                   
                   
                   
                 YNIGLTTKDPNVSLINYLPKNKIETTDVGQTL 
               
               
                   
                   
                   
                   
                 GYNIGGNFQSAPSIGGNGSFNYSKTISYTQKS 
               
               
                   
                   
                   
                   
                 YVSEVDKQNSKSVKWGVKANEFVTPDGKKS 
               
               
                   
                   
                   
                   
                 AHDRYLFVQSPNGPTGSAREYFAPDNQLPPL 
               
               
                   
                   
                   
                   
                 VQSGFNPSFITTLSHEKGSSDTSEFEISYGRNL 
               
               
                   
                   
                   
                   
                 DITYATLFPRTGIYAERKHNAFVNANFVVRY 
               
               
                   
                   
                   
                   
                 EVNWKTHEIKVKGHN 
               
               
                   
               
               
                 1077 
                 PRT 
                 Artificial 
                 Luk26 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYAEPWVWGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYVVFIGGVKGGHNSTPLSAIFTTGGHH 
               
               
                   
                   
                   
                   
                 HHHH 
               
               
                   
               
               
                 1078 
                 PRT 
                 Artificial 
                 LukABHC111 
                 EVQLQQSGAELVKPGASVKISCKASGYAFSS 
               
               
                   
                   
                   
                   
                 SWMNWLKQRPGKGLEWIGRIYPGDGDTNYN 
               
               
                   
                   
                   
                   
                 GKFKGKATLTADKSSSTAYMQLSSLTSEDSA 
               
               
                   
                   
                   
                   
                 VYFCARYGYDYDGEYYYAMDYWGQGTSVT 
               
               
                   
                   
                   
                   
                 VSSAKTTPPSVYPLAPGSAAQTNSMVTLGCL 
               
               
                   
                   
                   
                   
                 VKGYFPEPVTVTWNSGSLSSGVHTFPAVLES 
               
               
                   
                   
                   
                   
                 DLYTLSSSVTVPSSPRPSETVTCNVAHPASST 
               
               
                   
                   
                   
                   
                 KVDKKIVPRDCGCKPCICTVPEVSSVFIFPPKP 
               
               
                   
                   
                   
                   
                 KDVLTITLTPKVTCVVVDISKDDPEVQFSWF 
               
               
                   
                   
                   
                   
                 VDDVEVHTAQTQPREEQFNSTFRSVSELPIM 
               
               
                   
                   
                   
                   
                 HQDWLNGKEFKCRVNSAAFPAPIEKTISKTK 
               
               
                   
                   
                   
                   
                 GRPKAPQVYTIPPPKEQMAKDKVSLTCMITD 
               
               
                   
                   
                   
                   
                 FFPEDITVEWQWNGQPAENYKNTQPIMNTN 
               
               
                   
                   
                   
                   
                 GSYFVYSKLNVQKSNWEAGNTFTCSVLHEG 
               
               
                   
                   
                   
                   
                 LHNHHTEKSLSHSPGK 
               
               
                   
               
               
                 1079 
                 PRT 
                 Artificial 
                 LukABLC111 
                 DIVMTQSPTTMAASPGERITITCSAHSNLISNY 
               
               
                   
                   
                   
                   
                 LHWYQQKPGFSPKLLIYRTSNLASGVPARFS 
               
               
                   
                   
                   
                   
                 GSGSGTSYSLTIGTMEAEDVATYFCQQGSSIP 
               
               
                   
                   
                   
                   
                 FTFGSGTKLEIKRADAAPTVSIFPPSSEQLTSG 
               
               
                   
                   
                   
                   
                 GASVVCFLNNFYPKDINVKWKIDGSERQNGV 
               
               
                   
                   
                   
                   
                 LNSWTDQDSKDSTYSMSSTLTLTKDEYERHN 
               
               
                   
                   
                   
                   
                 SYTCEATHKTSTSPIVKSFNRNEC 
               
               
                   
               
               
                 1080 
                 PRT 
                 Artificial 
                 FabHC214 
                 EVQLQQSGAELVKPGASVKISCKASGYAFSS 
               
               
                   
                   
                   
                   
                 SWMNWLKQRPGKGLEWIGRIYPGDGDTNYN 
               
               
                   
                   
                   
                   
                 GKFKGKATLTADKSSSTAYMQLSSLTSEDSA 
               
               
                   
                   
                   
                   
                 VYFCARYGYDYDGEYYYAMDYWGQGTSVT 
               
               
                   
                   
                   
                   
                 VSSASTKGPSVFPLAPSSKSTSGGTAALGCLV 
               
               
                   
                   
                   
                   
                 KDYFPEPVTVSWNSGALTSGVHTFPAVLQSS 
               
               
                   
                   
                   
                   
                 GLYSLSSVVTVPSSSLGTQTYICNVNHKPSNT 
               
               
                   
                   
                   
                   
                 KVDKKVEPKSCHHHHHH 
               
               
                   
               
               
                 1081 
                 PRT 
                 Artificial 
                 FabLC214 
                 DIVMTQSPTTMAASPGERITITCSAHSNLISNY 
               
               
                   
                   
                   
                   
                 LHWYQQKPGFSPKLLIYRTSNLASGVPARFS 
               
               
                   
                   
                   
                   
                 GSGSGTSYSLTIGTMEAEDVATYFCQQGSSIP 
               
               
                   
                   
                   
                   
                 FTFGSGTKLEIKRTVAAPSVFIFPPSDEQLKSG 
               
               
                   
                   
                   
                   
                 TASVVCLLNNFYPREAKVQWKVDNALQSGN 
               
               
                   
                   
                   
                   
                 SQESVTEQDSKDSTYSLSSTLTLSKADYEKHK 
               
               
                   
                   
                   
                   
                 VYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 1082 
                 PRT 
                 Artificial 
                 FabHC229 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                   
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSSAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCHHHHHH 
               
               
                   
               
               
                 1083 
                 PRT 
                 Artificial 
                 FabLC229 
                 EIVLTQSPATLSLSPGERATLSCRASQSVSGYL 
               
               
                   
                   
                   
                   
                 GWYQQKPGQAPRLLIYGASSRATGIPDRFSG 
               
               
                   
                   
                   
                   
                 SGSGTDFTLTISRLEPEDFAVYYCQQYGSSPL 
               
               
                   
                   
                   
                   
                 TFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGT 
               
               
                   
                   
                   
                   
                 ASVVCLLNNFYPREAKVQWKVDNALQSGNS 
               
               
                   
                   
                   
                   
                 QESVTEQDSKDSTYSLSSTLTLSKADYEKHK 
               
               
                   
                   
                   
                   
                 VYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 1084 
                 PRT 
                 Artificial 
                 TD peptide 
                 LCBiot- 
               
               
                   
                   
                   
                   
                 TDTDTDTDTDTDTDTDTDTDHHHHHHHH- 
               
               
                   
                   
                   
                   
                 OH 
               
               
                   
               
               
                 1085 
                 PRT 
                 Artificial 
                 SD-GlcNAc 
                 LCBiot- 
               
               
                   
                   
                   
                 peptide 
                 SDSDSDSDSDSDSDSDSD(SGlcNAc)DHHHHH 
               
               
                   
                   
                   
                   
                 HHH-OH 
               
               
                   
               
               
                 1086 
                 PRT 
                 Artificial 
                 Hla H35L 
                 MKTRIVSSVTTTLLLGSILMNPVANAADSDIN 
               
               
                   
                   
                   
                 toxoid 
                 IKTGTTDIGSNTTVKTGDLVTYDKENGMLKK 
               
               
                   
                   
                   
                   
                 VFYSFIDDKNHNKKLLVIRTKGTIAGQYRVY 
               
               
                   
                   
                   
                   
                 SEEGANKSGLAWPSAFKVQLQLPDNEVAQIS 
               
               
                   
                   
                   
                   
                 DYYPRNSIDTKEYMSTLTYGFNGNVTGDDTG 
               
               
                   
                   
                   
                   
                 KIGGLIGANVSIGHTLKYVQPDFKTILESPTDK 
               
               
                   
                   
                   
                   
                 KVGWKVIFNNMVNQNWGPYDRDSWNPVYG 
               
               
                   
                   
                   
                   
                 NQLFMKTRNGSMKAADNFLDPNKASSLLSS 
               
               
                   
                   
                   
                   
                 GFSPDFATVITMDRKASKQQTNIDVIYERVRD 
               
               
                   
                   
                   
                   
                 DYQLHWTSTNWKGTNTKDKWIDRSSERYKI 
               
               
                   
                   
                   
                   
                 DWEKEEMTNHHHHHH 
               
               
                   
               
               
                 1087 
                 PRT 
                 Artificial 
                 Luk957 Hla 
                 LPAPKNLVVSRVTEDSARLSWGEAPIWVAFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVFQPNNFHSNPLSAIFTT 
               
               
                   
               
               
                 1088 
                 PRT 
                 Artificial 
                 Luk958 Hla 
                 LPAPKNLVVSRVTEDSARLSWEANAWDDVN 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYRESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                 domain 
                 GLKPGTEYTVSIYGVWNQTHYRWPSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 1089 
                 PRT 
                 Artificial 
                 Luk959 Hla 
                 LPAPKNLVVSRVTEDSARLSWTYIFPIFDSFLI 
               
               
                   
                   
                   
                 binding FN3 
                 QYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVLQYFEFTSNPLSAIFTT 
               
               
                   
               
               
                 1090 
                 PRT 
                 Artificial 
                 Luk960 Hla 
                 LPAPKNLVVSRVTEDSARLSWDSEELFLFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTIPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVWGHWDWYWKTSNPLSAIFTT 
               
               
                   
               
               
                 1091 
                 PRT 
                 Artificial 
                 Luk961 Hla 
                 LPAPKNLVVSRVTEDSARLSWDSEELFLFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVWGHWDWYWKTSNPLSAIFTT 
               
               
                   
               
               
                 1092 
                 PRT 
                 Artificial 
                 Luk962 Hla 
                 LPAPKNLVVSRVTEDSARLSWKVEHEFDSFLI 
               
               
                   
                   
                   
                 binding FN3 
                 QYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVGDSQWYFWRFSNPLSAIFTT 
               
               
                   
               
               
                 1093 
                 PRT 
                 Artificial 
                 Luk963 Hla 
                 LPAPKNLVVSRVTEDSARLSWGEEVHWLFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTSLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVAGYAHWFTTWSNPLSAIFTT 
               
               
                   
               
               
                 1094 
                 PRT 
                 Artificial 
                 Luk964 Hla 
                 LPAPKNLVVSRVTEDSARLSWAPSHFPRSFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVLTVATIRWQSNPLSAIFTT 
               
               
                   
               
               
                 1095 
                 PRT 
                 Artificial 
                 Luk965 Hla 
                 LPAPKNLVVSRVTEDSARLSWDEQLWIQFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVVPWLPNYWQVSNPLSAIFTT 
               
               
                   
               
               
                 1096 
                 PRT 
                 Artificial 
                 Luk966 Hla 
                 LPAPKNLVVSRVTEDSARLSWWSENWVNWF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVWEVKNRIRWLSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 1097 
                 PRT 
                 Artificial 
                 Luk967 Hla 
                 LPAPKNLVVSRVTEDSARLSWEANAWDDVN 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                 domain 
                 GLKPGTEYTVSIYGVWNQTHYRWPSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 1098 
                 PRT 
                 Artificial 
                 Luk968 Hla 
                 LPAPKNLVVSRVTEDSARLSWVDKRHPDFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVHGFLQWYWSTSNPLSAIFTT 
               
               
                   
               
               
                 1099 
                 PRT 
                 Artificial 
                 Luk969 Hla 
                 LPAPKNLVVSRVTEDSARLSWNSEIAEQFFFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVWGHWDWYWKTSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 1100 
                 PRT 
                 Artificial 
                 Luk970 Hla 
                 LPAPKNLVVSRVTEDSARLSWNRGLIPFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKLG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVGTYYPWWPLSNPLSAIFTT 
               
               
                   
               
               
                 1101 
                 PRT 
                 Artificial 
                 Luk971 Hla 
                 LPAPKNLVVSRVTEDSARLSWSPWFFGQFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVIELGQQYSFTSNPLSAIFTT 
               
               
                   
               
               
                 1102 
                 PRT 
                 Artificial 
                 Luk972 Hla 
                 LPAPKNLVVSRVTEDSARLSWNSEIAEQFFFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVWGHWDWYWKTSNPLSAI 
               
               
                   
                   
                   
                   
                 VTT 
               
               
                   
               
               
                 1103 
                 PRT 
                 Artificial 
                 Luk973 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GIGYPEFYRKGEAIQLRVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVSDLTTHWWLLSNPLSAIFTT 
               
               
                   
               
               
                 1104 
                 PRT 
                 Artificial 
                 Luk974 Hla 
                 LPAPKNLVVSRVTEDSARLSWGEEVHWLFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVAGYAHWFTTWSNPLSAIFTT 
               
               
                   
               
               
                 1105 
                 PRT 
                 Artificial 
                 Luk975 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AISYQELDPEGEAINLSVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTKYLVTIDGVKGGKASKPLPANFTT 
               
               
                   
               
               
                 1106 
                 PRT 
                 Artificial 
                 Luk976 Hla 
                 LPAPKNLVVSRVTEDSARLSWDTLTPWIIFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVQPWQVYYQYSNPLSAIFTT 
               
               
                   
               
               
                 1107 
                 PRT 
                 Artificial 
                 Luk977 Hla 
                 LPAPKNLVVSRVTEDSARLSWGASIERSRWF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 QKPGTEYTVSIYGVHNVPNLFVQGSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 1108 
                 PRT 
                 Artificial 
                 Luk978 Hla 
                 LPAPKNLVVSRVTEDSARLSWKAYHFIFDSFL 
               
               
                   
                   
                   
                 binding FN3 
                 IQYQESEKVGEAIVLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVRSDYVYWASNPLSAIFTT 
               
               
                   
               
               
                 1109 
                 PRT 
                 Artificial 
                 Luk979 Hla 
                 LPAPKNLVVSRVTEDSARLSWQIFPAFARFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVIFGPHTFQSNPLSAIFTT 
               
               
                   
               
               
                 1110 
                 PRT 
                 Artificial 
                 Luk980 Hla 
                 LPAPKNLVVSRVTEDSARLSWRISFPHFDSFLI 
               
               
                   
                   
                   
                 binding FN3 
                 QYQESEKVGEAIVLTVRGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYTVSIYGVLWYWRAYSNPLSAIFTT 
               
               
                   
               
               
                 1111 
                 PRT 
                 Artificial 
                 Luk981 Hla 
                 LPAPKNLVVSRVTEDSARLSWEANAWDDVN 
               
               
                   
                   
                   
                 binding FN3 
                 FDSFLIQYQESEKVGDAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                 domain 
                 GLKPGTEYTVSIYGVWNQTHYRWPSNPLSAI 
               
               
                   
                   
                   
                   
                 FTT 
               
               
                   
               
               
                 1112 
                 PRT 
                 Artificial 
                 Luk982 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIGYPEYHDAGEAIHLFVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYVVAIRGVKGGHASEPLHAHFTT 
               
               
                   
               
               
                 1113 
                 PRT 
                 Artificial 
                 Luk983 Hla 
                 LPAPKNLVVSRVTEDSARLSWKRNGVFEVNF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYQESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVWNQTHYRWPSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 1114 
                 PRT 
                 Artificial 
                 Luk984 Hla 
                 LPAPKNLVVSRVTEDSARLSWFVTWRNGFFD 
               
               
                   
                   
                   
                 binding FN3 
                 SFLIQYQESEKVGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                 domain 
                 KPGTEYTVSIYGVVHQYYPHYWFSNPLSAIFTT 
               
               
                   
               
               
                 1115 
                 PRT 
                 Artificial 
                 Luk985 Hla 
                 LPAPKNLVVSRVTEDSARLSWKRNGVFEVNF 
               
               
                   
                   
                   
                 binding FN3 
                 DSFLIQYRESEKVGEAIVLTVPGSERSYDLTG 
               
               
                   
                   
                   
                 domain 
                 LKPGTEYTVSIYGVWNQTHYRWPSNPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 1116 
                 PRT 
                 Artificial 
                 Luk986 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYTVSIYGVITLLFNGAVLSNPLSAIFTT 
               
               
                   
               
               
                 1117 
                 PRT 
                 Artificial 
                 Luk987 Hla 
                 LPAPKNLVVSRVTEDSARLSWVDKRHPDFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVSGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVHGFLQWYWSTSNPLSAIFTT 
               
               
                   
               
               
                 1118 
                 PRT 
                 Artificial 
                 Luk988 Hla 
                 LPAPKNLVVSRVTEDSARLSWAPSHFPRSFDS 
               
               
                   
                   
                   
                 binding FN3 
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVSIYGVLTVATIRWQSDPLSAIFTT 
               
               
                   
               
               
                 1119 
                 PRT 
                 Artificial 
                 Luk989 Hla 
                 LPAPKNLFVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 FIRYVEYGQPGEAIPLDVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYGVSINGVKGGNRSSPLFARFTT 
               
               
                   
               
               
                 1120 
                 PRT 
                 Artificial 
                 Luk990 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 SISYKEWWAVGEAIFLHVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYHVPISGVKGGDKSLPAHFTT 
               
               
                   
               
               
                 1121 
                 PRT 
                 Artificial 
                 Luk991 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GIHYGELWWNGEAIALVVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYKVWIPGVKGGSQSKPLWAFFTT 
               
               
                   
               
               
                 1122 
                 PRT 
                 Artificial 
                 Luk992 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 YIYYVEKPDPGEAIELYVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYRVRIEGVKGGDHSFPLVAGFTT 
               
               
                   
               
               
                 1123 
                 PRT 
                 Artificial 
                 Luk993 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFI 
               
               
                   
                   
                   
                 binding FN3 
                 IEYWEERQRGEAIGLTVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYRVIIVGVKGGTYSVPLEAFFTT 
               
               
                   
               
               
                 1124 
                 PRT 
                 Artificial 
                 Luk994 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GIEYHEPSKWGEAIGLNVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYSVQIKGVKGGWWSHPLPAAFTT 
               
               
                   
               
               
                 1125 
                 PRT 
                 Artificial 
                 Luk995 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 YIKYGEGNHGEAIWLFVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYYVEIVGVKGGFPSQPLHAQFTT 
               
               
                   
               
               
                 1126 
                 PRT 
                 Artificial 
                 Luk996 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 KIDYIEIDVEGEAIYLFVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEFRVRIPGVKGGDHSVPLAAAFTT 
               
               
                   
               
               
                 1127 
                 PRT 
                 Artificial 
                 Luk997 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFI 
               
               
                   
                   
                   
                 binding FN3 
                 ISYPEYWAIGEAIPLFVPGSERSYDLTGLKPGT 
               
               
                   
                   
                   
                 domain 
                 EYIVIIPGVKGGKGSNPLWAIFTT 
               
               
                   
               
               
                 1128 
                 PRT 
                 Artificial 
                 Luk998 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 EIGYFAEVDPGEAIQLDVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYAVNIPGVKGGYKSDPLNAHSTT 
               
               
                   
               
               
                 1129 
                 PRT 
                 Artificial 
                 Luk999 Hla 
                 LPAPKNLVVSRVTEDSVRLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 DIPYQELNRKGEAIQLTVPGSESSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYKVHIRGVKGGKQSLPLIAGFTT 
               
               
                   
               
               
                 1130 
                 PRT 
                 Artificial 
                 Luk1000 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 EITYHEIYKFGEAITLQVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYRVRITGVKGGWKSQPLVAKFTT 
               
               
                   
               
               
                 1131 
                 PRT 
                 Artificial 
                 Luk1001 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 DIRYDEEGYWGEAIPLHVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYTVWIYGVKGGRKSVPLVAEFTT 
               
               
                   
               
               
                 1132 
                 PRT 
                 Artificial 
                 Luk1002 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 NIRYKEPHRQGEAIPLIVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYNVHIHGVKGGKWSIPLYAWFTT 
               
               
                   
               
               
                 1133 
                 PRT 
                 Artificial 
                 Luk1003 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 DISYWEQVWQGEAIVLVVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 domain 
                 PGTEYPVFIRGVKGGSQSGPLRAFFTT 
               
               
                   
               
               
                 1134 
                 PRT 
                 Artificial 
                 Luk1004 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 YIYYYEFFRNGEAIVLFVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYWVRIKGVKGGRDSHPLYAGFTT 
               
               
                   
               
               
                 1135 
                 PRT 
                 Artificial 
                 Luk1005 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 SIGYHEVQQTGEAIRLFVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYEVEIRGVKGGTTSIPLWAHFTT 
               
               
                   
               
               
                 1136 
                 PRT 
                 Artificial 
                 Luk1006 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GITYEEPHEIGEAIFLVVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYYVEIQGVKGGDPSDPLNAAFTT 
               
               
                   
               
               
                 1137 
                 PRT 
                 Artificial 
                 Luk1007 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIHYREWSIWGEAIDLVVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYIVIIPGVKGGYVSNPLFAFFTTT 
               
               
                   
               
               
                 1138 
                 PRT 
                 Artificial 
                 Luk1008 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 HIYYSERQRIGEAIILVVPGSERSYDLTGLKPG 
               
               
                   
                   
                   
                 domain 
                 TEYIVKINGVKGGIISQPLIAPFTT 
               
               
                   
               
               
                 1139 
                 PRT 
                 Artificial 
                 Luk1009 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 NITYVEPVTEGEAISLVVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYSVKIHGVKGGPASNPLYAKFTT 
               
               
                   
               
               
                 1140 
                 PRT 
                 Artificial 
                 Luk1010 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 KIKYKEERHIGEAIHLGVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYEVYIVGVKGGSSSSPLFAHFTT 
               
               
                   
               
               
                 1141 
                 PRT 
                 Artificial 
                 Luk1011 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 RITYWEDNSTGEAILLVVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYRVAIVGVKGGDDSWPLLATFTT 
               
               
                   
               
               
                 1142 
                 PRT 
                 Artificial 
                 Luk1012 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 FILYVEYSVNGEAIELSVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYDVIIGGVKGGNHSKPLVAFFTT 
               
               
                   
               
               
                 1143 
                 PRT 
                 Artificial 
                 Luk1013 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 AIHYREWFIWGEAIDLVVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYIVIIPGVKGGYVSNPLFAFFTT 
               
               
                   
               
               
                 1144 
                 PRT 
                 Artificial 
                 Luk1014 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GIGYRELGGLGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYYVVIPGVKGGGLSLPLSAIFTT 
               
               
                   
               
               
                 1145 
                 PRT 
                 Artificial 
                 Luk1015 Hla 
                 LPAPKNLVVSRVTEDSARLSWTALDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GIPYRELGRGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYVVYITGVKGGMISTPLSAIFTT 
               
               
                   
               
               
                 1146 
                 PRT 
                 Artificial 
                 Luk1016 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GIPYRELGRGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYVVYITGVKGGMISTPLSAIFTT 
               
               
                   
               
               
                 1147 
                 PRT 
                 Artificial 
                 Luk1017 Hla 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 WIHYREVPVPGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYFVYIMGVKGGTFSAPLSAIFTT 
               
               
                   
               
               
                 1148 
                 PRT 
                 Artificial 
                 Luk1018 Hla 
                 LPAPKNLVVSRVTEDSACLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 binding FN3 
                 GIPYRELGRGGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                 domain 
                 GTEYVVYITGVKGGMISTPLSAIFTT 
               
               
                   
               
               
                 1149 
                 PRT 
                 Artificial 
                 LukA mut1 
                 MNSAHHHHHHHHHHGGGLNDIFEAQKIEWH 
               
               
                   
                   
                   
                   
                 EGSHKDSQDQNKKEHVDKSQQKDKRNVTN 
               
               
                   
                   
                   
                   
                 KDKNSTAPDDIGKNGKITKRTETVYDEKTNIL 
               
               
                   
                   
                   
                   
                 QNLQFDFIDDPTYDKNVLLVKKQGSIHSNLK 
               
               
                   
                   
                   
                   
                 FESHKEEKNSNWLKYPSEYHVDFQVKRNRK 
               
               
                   
                   
                   
                   
                 TEILDQLPKNKISTAKVDSTFKFDSTKGIGRTS 
               
               
                   
                   
                   
                   
                 SNSYSKTISYNQQNYDTIASGKNNNWHVHW 
               
               
                   
                   
                   
                   
                 SVIANDLKYGGEVKNRNDELLFYRNTRIATV 
               
               
                   
                   
                   
                   
                 ENPELSFASKYRYPALVRSGFNPEFLTYLSNE 
               
               
                   
                   
                   
                   
                 KSNEKTQFEVTYTRNQDILKNRPGIHYAPPIL 
               
               
                   
                   
                   
                   
                 EKNKDGQRLIVTYEVDWKNKTVKVVDKYS 
               
               
                   
                   
                   
                   
                 DDNKPYKAG 
               
               
                   
               
               
                 1150 
                 PRT 
                 Artificial 
                 LukB mut1 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTIN 
               
               
                   
                   
                   
                   
                 RGGLTGNITKESNYSETISYQQPSYRTLLDQS 
               
               
                   
                   
                   
                   
                 TSHKGVGWKVEAHLINNMGHDHTRQLTNDS 
               
               
                   
                   
                   
                   
                 DNRTKSEIFSLTRNGNLWAKDNFTPKDKMPV 
               
               
                   
                   
                   
                   
                 TVSEGFNPEFLAVMSHDKKDKGKSQFVVHY 
               
               
                   
                   
                   
                   
                 KRSMDEFKIDWNRHGFWGYWSGENHVDKK 
               
               
                   
                   
                   
                   
                 EEKLSALYEVDWKTHNVKFVKVLNDNEKK 
               
               
                   
               
               
                 1151 
                 PRT 
                 Artificial 
                 LukB mut2 
                 MKINSEIKQVSEKNLDGDTKMYTRTATTSDS 
               
               
                   
                   
                   
                   
                 QKNITQSLQFNFLTEPNYDKETVFIKAKGTIG 
               
               
                   
                   
                   
                   
                 SGLRILDPNGYWNSTLRWPGSYSVSIQNVDD 
               
               
                   
                   
                   
                   
                 NNNTNVTDFAPKNQDESREVKYTYGYKTGG 
               
               
                   
                   
                   
                   
                 DFSINRNITKESNYSETISYQQPSYRTLLDQST 
               
               
                   
                   
                   
                   
                 SHKGVGWKVEAHLINNMGHDHTRQLTNDS 
               
               
                   
                   
                   
                   
                 DNRTKSEIFSLTRNGNLWAKDNFTPKDKMPV 
               
               
                   
                   
                   
                   
                 TVSEGFNPEFLAVMSHDKKDKGKSQFVVHY 
               
               
                   
                   
                   
                   
                 KRSMDEFKIDWNRHGFWGYWSGENHVDKK 
               
               
                   
                   
                   
                   
                 EEKLSALYEVDWKTHNVKFVKVLNDNEKK 
               
               
                   
               
               
                 1152 
                 PRT 
                 Artificial 
                 TENCON_HIS_SA 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYTVSIYGVKGGHRSNPLSAIFTTGGHHH 
               
               
                   
                   
                   
                   
                 HHHGGGLNDIFEAQKIEWHE 
               
               
                   
               
               
                 1153 
                 PRT 
                 Artificial 
                 Luk17_HIS_SA 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FWITYEEKFYRGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYKVWIVGVKGGQGSWPLSAIFTTGGHH 
               
               
                   
                   
                   
                   
                 HHHHGGGLNDIFEAQKIEWHE 
               
               
                   
               
               
                 1154 
                 PRT 
                 Artificial 
                 Luk19_HIS_SA 
                 MLPAPKNLVVSRVTEDSARLSWYHAIHRLN 
               
               
                   
                   
                   
                   
                 HFDSFLIQYQESEKVGEAIVLTVPGSERSYDL 
               
               
                   
                   
                   
                   
                 AGLKPGTEYTVSIYGVLPDAFVSSNPLSAIFTT 
               
               
                   
                   
                   
                   
                 GGHHHHHHGGGLNDIFEAQKIEWHE 
               
               
                   
               
               
                 1155 
                 PRT 
                 Artificial 
                 Luk26_HIS_SA 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYAEPWVWGEAIVLTVPGSERSYDLTGL 
               
               
                   
                   
                   
                   
                 KPGTEYVVFIGGVKGGHNSTPLSAIFTTGGHH 
               
               
                   
                   
                   
                   
                 HHHHGGGLNDIFEAQKIEWHE 
               
               
                   
               
               
                 1156 
                 PRT 
                 Artificial 
                 Luk31_HIS_SA 
                 MLPAPNNLVVSRVTEDSARLSWDWDKYYTN 
               
               
                   
                   
                   
                   
                 RFDSFLIQYQESEKVGEAIVLTVPGSERSYDL 
               
               
                   
                   
                   
                   
                 TGLKPGTEYTVSIYGVLVRDYIRAAEWYSNP 
               
               
                   
                   
                   
                   
                 LSAIFTTGGHHHHHHGGGLNDIFEAQKIEWHE 
               
               
                   
               
               
                 1157 
                 PRT 
                 Artificial 
                 Luk32_HIS_SA 
                 MLPAPKNLVVSRVTEDSARLSWYHENAYLL 
               
               
                   
                   
                   
                   
                 FDSFLIQYQESEKVGEAIVLTVPGSERSYDLT 
               
               
                   
                   
                   
                   
                 GLKPGTEYTVSIYGVVYDLTPEKRSSNPLSAI 
               
               
                   
                   
                   
                   
                 FTTGGHHHHHHGGGLNDIFEAQKIEWHE 
               
               
                   
               
               
                 1158 
                 PRT 
                 Artificial 
                 Luk163_HIS_SA 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FYIEYWEPTSDGEAIALNVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYFVEIWGVKGGPRSPPLSAWFTTGGHH 
               
               
                   
                   
                   
                   
                 HHHHGGGLNDIFEAQKIEWHE 
               
               
                   
               
               
                 1159 
                 PRT 
                 Artificial 
                 Luk174_HIS_SA 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FDIEYGEPEKIGEAIWLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYWVFIYGVKGGALSRPLTATFTTGGHH 
               
               
                   
                   
                   
                   
                 HHHHGGGLNDIFEAQKIEWHE 
               
               
                   
               
               
                 1160 
                 PRT 
                 Artificial 
                 Luk187_HIS_SA 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FRILYFEYKRLGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYFVGIHGVKGGYISRPLSAIFTTGGHHH 
               
               
                   
                   
                   
                   
                 HHHGGGLNDIFEAQKIEWHE 
               
               
                   
               
               
                 1161 
                 PRT 
                 Artificial 
                 Luk188_HIS_SA 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIHYWEFNPAGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYFVGIHGVKGGGISWPLSAIFTTGGHHH 
               
               
                   
                   
                   
                   
                 HHHGGGLNDIFEAQKIEWHE 
               
               
                   
               
               
                 1162 
                 PRT 
                 Artificial 
                 Luk311_HIS_SA 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FWISYVEPDDGEAIELLVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYIVQIDGVKGGTTSVPLNARFTTGGHHH 
               
               
                   
                   
                   
                   
                 HHHGGGLNDIFEAQKIEWHE 
               
               
                   
               
               
                 1163 
                 PRT 
                 Artificial 
                 HC431 
                 QVQLQQSGAELMNPGASVKISCKSTGYKFSS 
               
               
                   
                   
                   
                   
                 YWIEWVKQRPGHGLEWMGEILPGSGSTNHN 
               
               
                   
                   
                   
                   
                 EKFKGKAIFTADASSNTAYMELSSLTSEDSAV 
               
               
                   
                   
                   
                   
                 YYCARTISTATDWFAYWGQGTLVTVSAAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNRFTQKSLSLSPGKGGGGSGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFWITYEEKFYRGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYKVWIVGVKGGQGSWPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 1164 
                 PRT 
                 Artificial 
                 LC431 
                 DVLMTQTPLSLPVSLGDQASISCRSSQTIVYS 
               
               
                   
                   
                   
                   
                 DGNTYLEWYLQKPGQSPKLLIYKVSNRFSGV 
               
               
                   
                   
                   
                   
                 PDRVSGSGSGTDFTLKISRVEAEDLGVYYCF 
               
               
                   
                   
                   
                   
                 QGSHVPYTFGGGTKLEIKRTVAAPSVFIFPPS 
               
               
                   
                   
                   
                   
                 DEQLKSGTASVVCLLNNFYPREAKVQWKVD 
               
               
                   
                   
                   
                   
                 NALQSGNSQESVTEQDSKDSTYSLSSTLTLSK 
               
               
                   
                   
                   
                   
                 ADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 1165 
                 PRT 
                 Artificial 
                 HC432 
                 EVQLQQSGGGLVKPGGSLKLSCAASGFTFSS 
               
               
                   
                   
                   
                   
                 YAMSWVRQTPEKRLEWVATITGGGTYTYYL 
               
               
                   
                   
                   
                   
                 DSVKGRFTISRDNAKTSLYLQMSSLRSEDTA 
               
               
                   
                   
                   
                   
                 MYYCARHRDGNYGCFDVWGAGTTVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNRFTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFWITYEEKFYRGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYKVWIVGVKGGQGSWPLS 
               
               
                   
                   
                   
                   
                 AIFTT 
               
               
                   
               
               
                 1166 
                 PRT 
                 Artificial 
                 LC432 
                 DIVLTQSPAIMSASLGERVTMTCTASSSVSSS 
               
               
                   
                   
                   
                   
                 YLHWYQQKPGSSPKLWVYSTSNLASGVPAR 
               
               
                   
                   
                   
                   
                 FSGSGSGSSYSLTISSMEPEDTATYYCHQYHR 
               
               
                   
                   
                   
                   
                 SPQTFGGGTKLEIKRTVAAPSVFIFPPSDEQLK 
               
               
                   
                   
                   
                   
                 SGTASVVCLLNNFYPREAKVQWKVDNALQS 
               
               
                   
                   
                   
                   
                 GNSQESVTEQDSKDSTYSLSSTLTLSKADYEK 
               
               
                   
                   
                   
                   
                 HKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 1167 
                 PRT 
                 Artificial 
                 HC505 
                 QVQLQQSGAELMNPGASVKISCKSTGYKFSS 
               
               
                   
                   
                   
                   
                 YWIEWVKQRPGHGLEWMGEILPGSGSTNHN 
               
               
                   
                   
                   
                   
                 EKFKGKAIFTADASSNTAYMELSSLTSEDSAV 
               
               
                   
                   
                   
                   
                 YYCARTISTATDWFAYWGQGTLVTVSAAST 
               
               
                   
                   
                   
                   
                 KGPSVFPLAPSSKSTSGGTAALGCLVKDYFPE 
               
               
                   
                   
                   
                   
                 PVTVSWNSGALTSGVHTFPAVLQSSGLYSLS 
               
               
                   
                   
                   
                   
                 SVVTVPSSSLGTQTYICNVNHKPSNTKVDKK 
               
               
                   
                   
                   
                   
                 VEPKSCDKTHTCPPCPAPPVAGPDVFLFPPKP 
               
               
                   
                   
                   
                   
                 KDTLMISRTPEVTCVVVDVSHEDPEVKFNWY 
               
               
                   
                   
                   
                   
                 VDGVEVHNAKTKPREEQYNSTYRVVSVLTV 
               
               
                   
                   
                   
                   
                 LHQDWLNGKEYKCKVSNAALPAPIAKTISKA 
               
               
                   
                   
                   
                   
                 KGQPREPQVYTLPPSRDELTKNQVSLTCLVK 
               
               
                   
                   
                   
                   
                 GFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
                   
                   
                   
                 GSFFLYSKLTVDKSRWQQGNVFSCSVMHEA 
               
               
                   
                   
                   
                   
                 LHNHYTQKSLSLSPGKGGGGSGGGGSGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSMLPAPKNLVVSRVTEDSARLSWTAP 
               
               
                   
                   
                   
                   
                 DAAFDSFWITYEEKFYRGEAIVLTVPGSERSY 
               
               
                   
                   
                   
                   
                 DLTGLKPGTEYKVWIVGVKGGQGSWPLSAIF 
               
               
                   
                   
                   
                   
                 TT 
               
               
                   
               
               
                 1168 
                 PRT 
                 Artificial 
                 LC505 
                 DVLMTQTPLSLPVSLGDQASISCRSSQTIVYS 
               
               
                   
                   
                   
                   
                 DGNTYLEWYLQKPGQSPKLLIYKVSNRFSGV 
               
               
                   
                   
                   
                   
                 PDRVSGSGSGTDFTLKISRVEAEDLGVYYCF 
               
               
                   
                   
                   
                   
                 QGSHVPYTFGGGTKLEIKRTVAAPSVFIFPPS 
               
               
                   
                   
                   
                   
                 DEQLKSGTASVVCLLNNFYPREAKVQWKVD 
               
               
                   
                   
                   
                   
                 NALQSGNSQESVTEQDSKDSTYSLSSTLTLSK 
               
               
                   
                   
                   
                   
                 ADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 1169 
                 PRT 
                 Artificial 
                 HC506 
                 EVQLQQSGGGLVKPGGSLKLSCAASGFTFSS 
               
               
                   
                   
                   
                   
                 YAMSWVRQTPEKRLEWVATITGGGTYTYYL 
               
               
                   
                   
                   
                   
                 DSVKGRFTISRDNAKTSLYLQMSSLRSEDTA 
               
               
                   
                   
                   
                   
                 MYYCARHRDGNYGCFDVWGAGTTVTVSSA 
               
               
                   
                   
                   
                   
                 STKGPSVFPLAPSSKSTSGGTAALGCLVKDYF 
               
               
                   
                   
                   
                   
                 PEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
                   
                   
                   
                 LSSVVTVPSSSLGTQTYICNVNHKPSNTKVDK 
               
               
                   
                   
                   
                   
                 KVEPKSCDKTHTCPPCPAPPVAGPDVFLFPPK 
               
               
                   
                   
                   
                   
                 PKDTLMISRTPEVTCVVVDVSHEDPEVKFNW 
               
               
                   
                   
                   
                   
                 YVDGVEVHNAKTKPREEQYNSTYRVVSVLT 
               
               
                   
                   
                   
                   
                 VLHQDWLNGKEYKCKVSNAALPAPIAKTISK 
               
               
                   
                   
                   
                   
                 AKGQPREPQVYTLPPSRDELTKNQVSLTCLV 
               
               
                   
                   
                   
                   
                 KGFYPSDIAVEWESNGQPENNYKTTPPVLDS 
               
               
                   
                   
                   
                   
                 DGSFFLYSKLTVDKSRWQQGNVFSCSVMHE 
               
               
                   
                   
                   
                   
                 ALHNHYTQKSLSLSPGKGGGGSGGGGSGGG 
               
               
                   
                   
                   
                   
                 GSGGGGSMLPAPKNLVVSRVTEDSARLSWT 
               
               
                   
                   
                   
                   
                 APDAAFDSFWITYEEKFYRGEAIVLTVPGSER 
               
               
                   
                   
                   
                   
                 SYDLTGLKPGTEYKVWIVGVKGGQGSWPLS 
               
               
                   
                   
                   
                   
                 AIFTT 
               
               
                   
               
               
                 1170 
                 PRT 
                 Artificial 
                 LC506 
                 DIVLTQSPAIMSASLGERVTMTCTASSSVSSS 
               
               
                   
                   
                   
                   
                 YLHWYQQKPGSSPKLWVYSTSNLASGVPAR 
               
               
                   
                   
                   
                   
                 FSGSGSGSSYSLTISSMEPEDTATYYCHQYHR 
               
               
                   
                   
                   
                   
                 SPQTFGGGTKLEIKRTVAAPSVFIFPPSDEQLK 
               
               
                   
                   
                   
                   
                 SGTASVVCLLNNFYPREAKVQWKVDNALQS 
               
               
                   
                   
                   
                   
                 GNSQESVTEQDSKDSTYSLSSTLTLSKADYEK 
               
               
                   
                   
                   
                   
                 HKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 1171 
                 PRT 
                 Artificial 
                 Luk047001 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                 (SAFN3- 
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 TENCON) 
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFLIQYQESEKVGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYTVSIYGVKG 
               
               
                   
                   
                   
                   
                 GHRSNPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1172 
                 PRT 
                 Artificial 
                 Luk047002 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                 (SABD- 
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                 TENCON) 
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFLIQYQESEKVGEAIVLTVPG 
               
               
                   
                   
                   
                   
                 SERSYDLTGLKPGTEYTVSIYGVKGGHRSNP 
               
               
                   
                   
                   
                   
                 LSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1173 
                 PRT 
                 Artificial 
                 Luk047003 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                 (TFFN3- 
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 TENCON) 
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFLIQYQESEKVGEAIV 
               
               
                   
                   
                   
                   
                 LTVPGSERSYDLTGLKPGTEYTVSIYGVKGG 
               
               
                   
                   
                   
                   
                 HRSNPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1174 
                 PRT 
                 Artificial 
                 Luk047004 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                 (SAFN3- 
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 LukE26) 
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFHIEYAEPWVWGE 
               
               
                   
                   
                   
                   
                 AIVLTVPGSERSYDLTGLKPGTEYVVFIGGVK 
               
               
                   
                   
                   
                   
                 GGHNSTPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1175 
                 PRT 
                 Artificial 
                 Luk047005 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                 (SABD- 
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                 LukE26) 
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFHIEYAEPWVWGEAIVLTVP 
               
               
                   
                   
                   
                   
                 GSERSYDLTGLKPGTEYVVFIGGVKGGHNST 
               
               
                   
                   
                   
                   
                 PLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1176 
                 PRT 
                 Artificial 
                 Luk047006 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                 (TFFN3- 
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                 LukE26) 
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFHIEYAEPWVWGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYVVFIGGVKG 
               
               
                   
                   
                   
                   
                 GHNSTPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1177 
                 PRT 
                 Artificial 
                 TENCON_HIS 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FLIQYQESEKVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYTVSIYGVKGGHRSNPLSAIFTTGGHHH 
               
               
                   
                   
                   
                   
                 HHH 
               
               
                   
               
               
                 1178 
                 PRT 
                 Artificial 
                 Luk047007 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFWITYEEKFYRGEA 
               
               
                   
                   
                   
                   
                 IVLTVPGSERSYDLTGLKPGTEYKVWIVGVK 
               
               
                   
                   
                   
                   
                 GGQGSWPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1179 
                 PRT 
                 Artificial 
                 Luk047008 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFWITYEEKFYRGEAIVLTVP 
               
               
                   
                   
                   
                   
                 GSERSYDLTGLKPGTEYKVWIVGVKGGQGS 
               
               
                   
                   
                   
                   
                 WPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1180 
                 PRT 
                 Artificial 
                 Luk047009 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFWITYEEKFYRGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYKVWIVGVKG 
               
               
                   
                   
                   
                   
                 GQGSWPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1181 
                 PRT 
                 Artificial 
                 Luk047010 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWYHAIHRLNHFDSFLIQYQESEKV 
               
               
                   
                   
                   
                   
                 GEAIVLTVPGSERSYDLAGLKPGTEYTVSIYG 
               
               
                   
                   
                   
                   
                 VLPDAFVSSNPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1182 
                 PRT 
                 Artificial 
                 Luk047011 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWYHAIHRLNHFDSFLIQYQESEKVGEAIVLT 
               
               
                   
                   
                   
                   
                 VPGSERSYDLAGLKPGTEYTVSIYGVLPDAF 
               
               
                   
                   
                   
                   
                 VSSNPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1183 
                 PRT 
                 Artificial 
                 Luk047012 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWYHAIHRLNHFDSFLIQYQESEKVG 
               
               
                   
                   
                   
                   
                 EAIVLTVPGSERSYDLAGLKPGTEYTVSIYGV 
               
               
                   
                   
                   
                   
                 LPDAFVSSNPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1184 
                 PRT 
                 Artificial 
                 Luk047013 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFPIVYQEWQFYGEA 
               
               
                   
                   
                   
                   
                 IVLTVPGSERSYDLTGLKPGTEYLVDIYGVKG 
               
               
                   
                   
                   
                   
                 GSWSYPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1185 
                 PRT 
                 Artificial 
                 Luk047014 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFPIVYQEWQFYGEAIVLTVP 
               
               
                   
                   
                   
                   
                 GSERSYDLTGLKPGTEYLVDIYGVKGGSWSY 
               
               
                   
                   
                   
                   
                 PLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1186 
                 PRT 
                 Artificial 
                 Luk047015 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFPIVYQEWQFYGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYLVDIYGVKG 
               
               
                   
                   
                   
                   
                 GSWSYPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1187 
                 PRT 
                 Artificial 
                 Luk047016 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPNNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWDWDKYYTNRFDSFLIQYQESEKV 
               
               
                   
                   
                   
                   
                 GEAIVLTVPGSERSYDLTGLKPGTEYTVSIYG 
               
               
                   
                   
                   
                   
                 VLVRDYIRAAEWYSNPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1188 
                 PRT 
                 Artificial 
                 Luk047017 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPNNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWDWDKYYTNRFDSFLIQYQESEKVGEAIVL 
               
               
                   
                   
                   
                   
                 TVPGSERSYDLTGLKPGTEYTVSIYGVLVRD 
               
               
                   
                   
                   
                   
                 YIRAAEWYSNPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1189 
                 PRT 
                 Artificial 
                 Luk047018 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPNNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWDWDKYYTNRFDSFLIQYQESEKV 
               
               
                   
                   
                   
                   
                 GEAIVLTVPGSERSYDLTGLKPGTEYTVSIYG 
               
               
                   
                   
                   
                   
                 VLVRDYIRAAEWYSNPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1190 
                 PRT 
                 Artificial 
                 Luk047019 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWYHENAYLLFDSFLIQYQESEKVG 
               
               
                   
                   
                   
                   
                 EAIVLTVPGSERSYDLTGLKPGTEYTVSIYGV 
               
               
                   
                   
                   
                   
                 VYDLTPEKRSSNPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1191 
                 PRT 
                 Artificial 
                 Luk047020 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWYHENAYLLFDSFLIQYQESEKVGEAIVLT 
               
               
                   
                   
                   
                   
                 VPGSERSYDLTGLKPGTEYTVSIYGVVYDLTP 
               
               
                   
                   
                   
                   
                 EKRSSNPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1192 
                 PRT 
                 Artificial 
                 Luk047021 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWYHENAYLLFDSFLIQYQESEKVGE 
               
               
                   
                   
                   
                   
                 AIVLTVPGSERSYDLTGLKPGTEYTVSIYGVV 
               
               
                   
                   
                   
                   
                 YDLTPEKRSSNPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1193 
                 PRT 
                 Artificial 
                 Luk047022 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFLIQYQESEKVGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYTVSIYGVELI 
               
               
                   
                   
                   
                   
                 YHGWLDFVFSNPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1194 
                 PRT 
                 Artificial 
                 Luk047023 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFLIQYQESEKVGEAIVLTVPG 
               
               
                   
                   
                   
                   
                 SERSYDLTGLKPGTEYTVSIYGVELIYHGWL 
               
               
                   
                   
                   
                   
                 DFVFSNPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1195 
                 PRT 
                 Artificial 
                 Luk047024 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFLIQYQESEKVGEAIV 
               
               
                   
                   
                   
                   
                 LTVPGSERSYDLTGLKPGTEYTVSIYGVELIY 
               
               
                   
                   
                   
                   
                 HGWLDFVFSNPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1196 
                 PRT 
                 Artificial 
                 Luk047025 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFYIEYWEPTSDGEAI 
               
               
                   
                   
                   
                   
                 ALNVPGSERSYDLTGLKPGTEYFVEIWGVKG 
               
               
                   
                   
                   
                   
                 GPRSPPLSAWFTTGGHHHHHH 
               
               
                   
               
               
                 1197 
                 PRT 
                 Artificial 
                 Luk047026 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFYIEYWEPTSDGEAIALNVP 
               
               
                   
                   
                   
                   
                 GSERSYDLTGLKPGTEYFVEIWGVKGGPRSP 
               
               
                   
                   
                   
                   
                 PLSAWFTTGGHHHHHH 
               
               
                   
               
               
                 1198 
                 PRT 
                 Artificial 
                 Luk047027 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFYIEYWEPTSDGEAI 
               
               
                   
                   
                   
                   
                 ALNVPGSERSYDLTGLKPGTEYFVEIWGVKG 
               
               
                   
                   
                   
                   
                 GPRSPPLSAWFTTGGHHHHHH 
               
               
                   
               
               
                 1199 
                 PRT 
                 Artificial 
                 Luk047028 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFDIEYGEPEKIGEAI 
               
               
                   
                   
                   
                   
                 WLTVPGSERSYDLTGLKPGTEYWVFIYGVKG 
               
               
                   
                   
                   
                   
                 GALSRPLTATFTTGGHHHHHH 
               
               
                   
               
               
                 1200 
                 PRT 
                 Artificial 
                 Luk047029 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFDIEYGEPEKIGEAIWLTVPG 
               
               
                   
                   
                   
                   
                 SERSYDLTGLKPGTEYWVFIYGVKGGALSRP 
               
               
                   
                   
                   
                   
                 LTATFTTGGHHHHHH 
               
               
                   
               
               
                 1201 
                 PRT 
                 Artificial 
                 Luk047030 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFDIEYGEPEKIGEAIW 
               
               
                   
                   
                   
                   
                 LTVPGSERSYDLTGLKPGTEYWVFIYGVKGG 
               
               
                   
                   
                   
                   
                 ALSRPLTATFTTGGHHHHHH 
               
               
                   
               
               
                 1202 
                 PRT 
                 Artificial 
                 Luk047031 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFRILYFEYKRLGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYFVGIHGVKG 
               
               
                   
                   
                   
                   
                 GYISRPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1203 
                 PRT 
                 Artificial 
                 Luk047032 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFRILYFEYKRLGEAIVLTVPG 
               
               
                   
                   
                   
                   
                 SERSYDLTGLKPGTEYFVGIHGVKGGYISRPL 
               
               
                   
                   
                   
                   
                 SAIFTTGGHHHHHH 
               
               
                   
               
               
                 1204 
                 PRT 
                 Artificial 
                 Luk047033 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFRILYFEYKRLGEAIV 
               
               
                   
                   
                   
                   
                 LTVPGSERSYDLTGLKPGTEYFVGIHGVKGG 
               
               
                   
                   
                   
                   
                 YISRPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1205 
                 PRT 
                 Artificial 
                 Luk047034 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFHIHYWEFNPAGEA 
               
               
                   
                   
                   
                   
                 IVLTVPGSERSYDLTGLKPGTEYFVGIHGVKG 
               
               
                   
                   
                   
                   
                 GGISWPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1206 
                 PRT 
                 Artificial 
                 Luk047035 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFHIHYWEFNPAGEAIVLTVP 
               
               
                   
                   
                   
                   
                 GSERSYDLTGLKPGTEYFVGIHGVKGGGISW 
               
               
                   
                   
                   
                   
                 PLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1207 
                 PRT 
                 Artificial 
                 Luk047036 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFHIHYWEFNPAGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYFVGIHGVKG 
               
               
                   
                   
                   
                   
                 GGISWPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1208 
                 PRT 
                 Artificial 
                 Luk047037 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFHIFYHETDAYGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYFVVIHGVKG 
               
               
                   
                   
                   
                   
                 GFISSPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1209 
                 PRT 
                 Artificial 
                 Luk047038 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFHIFYHETDAYGEAIVLTVP 
               
               
                   
                   
                   
                   
                 GSERSYDLTGLKPGTEYFVVIHGVKGGFISSP 
               
               
                   
                   
                   
                   
                 LSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1210 
                 PRT 
                 Artificial 
                 Luk047039 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFHIFYHETDAYGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYFVVIHGVKG 
               
               
                   
                   
                   
                   
                 GFISSPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1211 
                 PRT 
                 Artificial 
                 Luk047040 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFWISYVEPDDGEAI 
               
               
                   
                   
                   
                   
                 ELLVPGSERSYDLTGLKPGTEYIVQIDGVKGG 
               
               
                   
                   
                   
                   
                 TTSVPLNARFTTGGHHHHHH 
               
               
                   
               
               
                 1212 
                 PRT 
                 Artificial 
                 Luk047041 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFWISYVEPDDGEAIELLVPGS 
               
               
                   
                   
                   
                   
                 ERSYDLTGLKPGTEYIVQIDGVKGGTTSVPLN 
               
               
                   
                   
                   
                   
                 ARFTTGGHHHHHH 
               
               
                   
               
               
                 1213 
                 PRT 
                 Artificial 
                 Luk047042 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFWISYVEPDDGEAIE 
               
               
                   
                   
                   
                   
                 LLVPGSERSYDLTGLKPGTEYIVQIDGVKGGT 
               
               
                   
                   
                   
                   
                 TSVPLNARFTTGGHHHHHH 
               
               
                   
               
               
                 1214 
                 PRT 
                 Artificial 
                 Luk047043 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFGIGYLEYPWYGEA 
               
               
                   
                   
                   
                   
                 IVLTVPGSERSYDLTGLKPGTEYFVDIYGVKG 
               
               
                   
                   
                   
                   
                 GWWSYPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1215 
                 PRT 
                 Artificial 
                 Luk047044 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFGIGYLEYPWYGEAIVLTVP 
               
               
                   
                   
                   
                   
                 GSERSYDLTGLKPGTEYFVDIYGVKGGWWS 
               
               
                   
                   
                   
                   
                 YPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1216 
                 PRT 
                 Artificial 
                 Luk047045 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFGIGYLEYPWYGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYFVDIYGVKG 
               
               
                   
                   
                   
                   
                 GWWSYPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1217 
                 PRT 
                 Artificial 
                 Luk047046 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFNIDYFEYYEFGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYFVDIYGVKG 
               
               
                   
                   
                   
                   
                 GSWSLPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1218 
                 PRT 
                 Artificial 
                 Luk047047 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFNIDYFEYYEFGEAIVLTVPG 
               
               
                   
                   
                   
                   
                 SERSYDLTGLKPGTEYFVDIYGVKGGSWSLP 
               
               
                   
                   
                   
                   
                 LSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1219 
                 PRT 
                 Artificial 
                 Luk047048 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFNIDYFEYYEFGEAIV 
               
               
                   
                   
                   
                   
                 LTVPGSERSYDLTGLKPGTEYFVDIYGVKGG 
               
               
                   
                   
                   
                   
                 SWSLPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1220 
                 PRT 
                 Artificial 
                 Luk047049 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFDISYDEYPEFGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYLVDIIGVKGG 
               
               
                   
                   
                   
                   
                 EISLPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1221 
                 PRT 
                 Artificial 
                 Luk047050 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFDISYDEYPEFGEAIVLTVPG 
               
               
                   
                   
                   
                   
                 SERSYDLTGLKPGTEYLVDIIGVKGGEISLPLS 
               
               
                   
                   
                   
                   
                 AIFTTGGHHHHHH 
               
               
                   
               
               
                 1222 
                 PRT 
                 Artificial 
                 Luk047051 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFDISYDEYPEFGEAIV 
               
               
                   
                   
                   
                   
                 LTVPGSERSYDLTGLKPGTEYLVDIIGVKGGE 
               
               
                   
                   
                   
                   
                 ISLPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1223 
                 PRT 
                 Artificial 
                 Luk047052 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFNIHYAEYPDFGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYIVDIWGVKG 
               
               
                   
                   
                   
                   
                 GLGSWPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1224 
                 PRT 
                 Artificial 
                 Luk047053 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFNIHYAEYPDFGEAIVLTVPG 
               
               
                   
                   
                   
                   
                 SERSYDLTGLKPGTEYIVDIWGVKGGLGSWP 
               
               
                   
                   
                   
                   
                 LSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1225 
                 PRT 
                 Artificial 
                 Luk047054 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFNIHYAEYPDFGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYIVDIWGVKG 
               
               
                   
                   
                   
                   
                 GLGSWPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1226 
                 PRT 
                 Artificial 
                 Luk047055 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFVIFYGEYENGGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYFVIIVGVKGG 
               
               
                   
                   
                   
                   
                 FDSKPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1227 
                 PRT 
                 Artificial 
                 Luk047056 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFVIFYGEYENGGEAIVLTVP 
               
               
                   
                   
                   
                   
                 GSERSYDLTGLKPGTEYFVIIVGVKGGFDSKP 
               
               
                   
                   
                   
                   
                 LSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1228 
                 PRT 
                 Artificial 
                 Luk047057 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFVIFYGEYENGGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYFVIIVGVKGG 
               
               
                   
                   
                   
                   
                 FDSKPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1229 
                 PRT 
                 Artificial 
                 Luk047058 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFQIFYQEVVEWGEA 
               
               
                   
                   
                   
                   
                 IVLTVPGSERSYDLTGLKPGTEYFVVIHGVKG 
               
               
                   
                   
                   
                   
                 GWISDPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1230 
                 PRT 
                 Artificial 
                 Luk047059 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFQIFYQEVVEWGEAIVLTVP 
               
               
                   
                   
                   
                   
                 GSERSYDLTGLKPGTEYFVVIHGVKGGWISD 
               
               
                   
                   
                   
                   
                 PLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1231 
                 PRT 
                 Artificial 
                 Luk047060 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFQIFYQEVVEWGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYFVVIHGVKG 
               
               
                   
                   
                   
                   
                 GWISDPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1232 
                 PRT 
                 Artificial 
                 Luk047061 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFAIFYVELVWKGEA 
               
               
                   
                   
                   
                   
                 IVLTVPGSERSYDLTGLKPGTEYFVVIHGVKG 
               
               
                   
                   
                   
                   
                 GYISDPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1233 
                 PRT 
                 Artificial 
                 Luk047062 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFAIFYVELVWKGEAIVLTVP 
               
               
                   
                   
                   
                   
                 GSERSYDLTGLKPGTEYFVVIHGVKGGYISDP 
               
               
                   
                   
                   
                   
                 LSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1234 
                 PRT 
                 Artificial 
                 Luk047063 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFAIFYVELVWKGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYFVVIHGVKG 
               
               
                   
                   
                   
                   
                 GYISDPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1235 
                 PRT 
                 Artificial 
                 Luk047064 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFVIFYHETRVTGEAI 
               
               
                   
                   
                   
                   
                 VLTVPGSERSYDLTGLKPGTEYLVVIHGVKG 
               
               
                   
                   
                   
                   
                 GYISEPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1236 
                 PRT 
                 Artificial 
                 Luk047065 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFVIFYHETRVTGEAIVLTVPG 
               
               
                   
                   
                   
                   
                 SERSYDLTGLKPGTEYLVVIHGVKGGYISEPL 
               
               
                   
                   
                   
                   
                 SAIFTTGGHHHHHH 
               
               
                   
               
               
                 1237 
                 PRT 
                 Artificial 
                 Luk047066 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFVIFYHETRVTGEAIV 
               
               
                   
                   
                   
                   
                 LTVPGSERSYDLTGLKPGTEYLVVIHGVKGG 
               
               
                   
                   
                   
                   
                 YISEPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1238 
                 PRT 
                 Artificial 
                 Luk047067 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FHIEYWEQSIVGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYRVWIYGVKGGNDSWPLSAIFTTGGGG 
               
               
                   
                   
                   
                   
                 SGGGGSGGGGSGGGGSMLPAPKNLVVSRVT 
               
               
                   
                   
                   
                   
                 EDSARLSWTAPDAAFDSFLIDYWEGEFDGEA 
               
               
                   
                   
                   
                   
                 IHLFVPGSERSYDLTGLKPGTEYDVFIVGVKG 
               
               
                   
                   
                   
                   
                 GHGSDPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1239 
                 PRT 
                 Artificial 
                 Luk047068 
                 MTIDEWLLKEAKEKAIEELKKAGITSDYYFD 
               
               
                   
                   
                   
                   
                 LINKAKTVEGVNALKDEILKAGGGGSGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSMLPAPKNLVVSRVTEDSARL 
               
               
                   
                   
                   
                   
                 SWTAPDAAFDSFLIDYWEGEFDGEAIHLFVP 
               
               
                   
                   
                   
                   
                 GSERSYDLTGLKPGTEYDVFIVGVKGGHGSD 
               
               
                   
                   
                   
                   
                 PLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1240 
                 PRT 
                 Artificial 
                 Luk047069 
                 MLPAPKNLVVSRVTEDSARLSWTAPDAAFDS 
               
               
                   
                   
                   
                   
                 FAIEYEELRDWGEAIVLTVPGSERSYDLTGLK 
               
               
                   
                   
                   
                   
                 PGTEYSVSITGVKGGAESWPLSAIFTTGGGGS 
               
               
                   
                   
                   
                   
                 GGGGSGGGGSGGGGSMLPAPKNLVVSRVTE 
               
               
                   
                   
                   
                   
                 DSARLSWTAPDAAFDSFLIDYWEGEFDGEAI 
               
               
                   
                   
                   
                   
                 HLFVPGSERSYDLTGLKPGTEYDVFIVGVKG 
               
               
                   
                   
                   
                   
                 GHGSDPLSAIFTTGGHHHHHH 
               
               
                   
               
               
                 1241 
                 PRT 
                 Artificial 
                 TENCON 
                 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSF 
               
               
                   
                   
                   
                 parent 
                 LIQYQESEKVGEAIVLTVPGSERSYDLTGLKP 
               
               
                   
                   
                   
                   
                 GTEYTVSIYGVKGGHRSNPLSAIFTT 
               
               
                   
               
               
                 1242 
                 PRT 
                 Human 
                 CR-5133 VH 
                 EVQLVETGGGLVKPGGSLRLSCSASRFSFRD 
               
               
                   
                   
                   
                   
                 YYMTWIRQAPGKGPEWVSHISGSGSTIYYAD 
               
               
                   
                   
                   
                   
                 SVRGRFTISRDNAKSSLYLQMDSLQADDTAV 
               
               
                   
                   
                   
                   
                 YYCARGGRATSYYWVHWGPGTLVTVSS 
               
               
                   
               
               
                 1243 
                 PRT 
                 Human 
                 CR-5133 VL 
                 EIVLTQSPATLSLSPGERATLSCRASQSVSGYL 
               
               
                   
                   
                   
                   
                 GWYQQKPGQAPRLLIYGASSRATGIPDRFSG 
               
               
                   
                   
                   
                   
                 SGSGTDFTLTISRLEPEDFAVYYCQQYGSSPL 
               
               
                   
                   
                   
                   
                 TFGGGTKLEIK 
               
               
                   
               
            
           
         
       
     
     Although preferred embodiments have been depicted and described in detail herein, it will be apparent to those skilled in the relevant art that various modifications, additions, substitutions, and the like can be made without departing from the spirit of the disclosure and these are therefore considered to be within the scope of the disclosure as defined in the claims which follow.