Patent Publication Number: US-2021170112-A1

Title: Injection instrument set

Description:
TECHNICAL FIELD 
     The present invention relates to an injection instrument set. 
     Priority is claimed on Japanese Patent Application No. 2018-129914, filed Jul. 9, 2018, the content of which is incorporated herein by reference. 
     BACKGROUND ART 
     In recent years, regenerative medicine in which cells or aggregates thereof obtained by inducing differentiation from stem cells such as iPS cells are transplanted into an affected tissue has attracted attention. 
     Conventionally, in regenerative medicine, cells, drugs, and the like are injected into the affected tissue using an injection instrument. As an injection instrument, an injection instrument having an injection needle is known (refer to, for example, Patent Literature 1 and 2). The injection needle is formed in a tubular shape and is inserted into an injection target such as an affected tissue. Thus, the injection instrument injects an injection liquid containing cells, drugs, and the like into the injection target. 
     CITATION LIST 
     Patent Literature 
     
         
         [Patent Literature 1] 
       
    
     Published Japanese Translation No. 2013-514114 of the PCT International Publication
     [Patent Literature 2]   

     Published Japanese Translation No. 2013-544600 of the PCT International Publication
     [Patent Literature 3]   

     Japanese Unexamined Patent Application, First Publication No. 2016-5543 
     SUMMARY OF INVENTION 
     Technical Problem 
     However, the injection instruments described in Patent Literature 1 and 2have a constitution in which an injection needle is inserted perpendicularly into a shallow portion. Therefore, the injection needle may pass beyond a shallow portion when the injection liquid needs to be injected into a shallow portion of an injection target, and the injection liquid may not be injected into this shallow portion. 
     Therefore, it is conceivable to insert the injection needle at an angle into the shallow portion. However, an operation in which the injection needle is inserted at an angle is unstable. Therefore, in the conventional injection instrument, it has been difficult to inject the injection liquid into a shallow portion. Further, in the injection needle and injection instrument set described in Patent Literature 3, since a syringe is disposed in an oblique direction, it is necessary to inject the injection liquid in the oblique direction, and since an inclined surface of a support block has a constant angle, it is difficult to make the injection needle correspond to the shallow portion according to a thickness of the tissue (the injection target). 
     An aspect of the present invention is in view of the above circumstances and is to provide an injection instrument set in which, when an injection liquid is injected into a shallow portion of an injection target, a syringe is not disposed in an oblique direction, a nearby side can be easily seen, an injection angle is easily changed according to a thickness of a tissue, and thus drugs or cells can be injected over a wide area and shallowly without passing beyond the tissue. 
     Solution to Problem 
     In order to solve the problems and achieve the object, the present invention has adopted the following aspects. 
     (1) An injection instrument set according to an aspect of the present invention includes: a tubular injection instrument in which an injection liquid is accommodated; and a guide member disposed on a surface of an injection target of the injection liquid, wherein the injection instrument has an injection needle which is inserted into the injection target and injects the injection liquid into the injection target, and the guide member includes: a guide passage which is disposed at a predetermined angle with respect to a surface of the guide member in contact with the injection target, allows the injection needle to be inserted, and guides the injection needle to the surface of the injection target; and an anti-slip portion disposed at a portion at which the guide member comes into contact with the surface of the injection target. 
     According to the aspect (1), the injection instrument having the injection needle and the guide member having the guide passage disposed obliquely with respect to the surface of the injection target are provided, and when the injection liquid is injected into a shallow portion of the injection target, an inclination angle of the guide passage is reduced, and the injection needle is inserted into the guide passage and inserted obliquely into the shallow portion. Further, the injection needle is guided by the guide passage and is obliquely inserted into the shallow portion by mounting the guide member on the surface (a tissue surface) of the injection target. Therefore, an insertion operation of the injection needle can be performed stably. In addition, the connection portion allows the syringe to be held in a state close to upright rather than in an oblique direction, and thus a field of view at the nearby side is widened. Therefore, the injection needle can be easily disposed in the shallow portion. Thus, in the above-described aspect (1), the injection liquid can be easily injected into the shallow portion of the injection target. 
     (2) In the aspect (1), the guide member may be formed of a transparent material. 
     According to the aspect (2), since a state of the injection target can be visually observed, it is possible to perform an injection operation of the injection liquid while the state of the injection target is easily grasped. Thus, in the above-described aspect (2), the injection operation of the injection liquid can be efficiently performed. 
     (3) In the aspect (1) or (2), the guide member may have a positioning portion which comes into contact with the injection instrument when the injection needle is inserted and disposes an injection position of the injection liquid due to the injection needle in a shallow portion of the injection target. 
     According to the aspect (3), when the injection needle is inserted, an injection position is reliably placed in the shallow portion of the injection target. Therefore, in the above-described aspect (3), the injection liquid can be more easily injected into the shallow portion of the injection target. 
     (4) In any one of the aspects (1) to (3), the injection instrument may have a plurality of injection needles, and the guide member may have a plurality of guide passages corresponding to the plurality of injection needles. 
     According to the aspect (4), it is possible to inject a large amount of the injection liquid over a wide range as compared with a case in which one injection needle and one guide passage are provided. Therefore, in the above-described aspect (4), the injection liquid can be efficiently injected into the shallow portion of the injection target. 
     (5) In any one of the aspects (1) to (4), the guide passage may allow the injection needle to be inserted from both sides of the guide member in a predetermined first direction and may extend in the first direction, and one guide passage and the other guide passage of the guide passages on the both sides may be alternately disposed in a second direction intersecting the first direction. 
     According to the aspect (5), it is possible to shorten a length of the guide member in the first direction as compared with a case in which the guide passages on both sides are disposed to face each other. Therefore, in the above-described aspect (5), it is possible to reduce a size of the guide member. 
     (6) In any one of the aspects (1) to (5), a tip end of the injection needle may be closed, and a plurality of discharge holes spirally disposed in a lengthwise direction of the injection needle may be disposed in a peripheral surface of a portion of the injection needle which is disposed in a shallow portion of the injection target. 
     According to the aspect (6), when the injection liquid is injected, the injection liquid is spirally discharged from a plurality of discharge holes into the shallow portion, and thus the injection liquid can be injected into a wide range of the shallow portion. Therefore, in the above-described aspect (6), the injection liquid can be efficiently injected into the shallow portion of the injection target. 
     (7) In any one of the aspects (1) to (6), a diameter of an insertion side end portion of the injection needle of the guide passage may expand from an inner side to an outer side of the insertion side end portion in an axial direction. 
     According to the aspect (7), an insertion range of the injection needle of the guide passage expands. Therefore, in the above-described aspect (7), the injection needle can be easily inserted into the guide passage. 
     (8) In any one of the aspects (1) to (7), the guide member may be fixed to the surface of the injection target and may be mounted in a state in which the guide member is able to be disposed between a vibration suppression device configured to curb vibration of the injection target and the surface of the injection target. 
     According to the aspect (8), when the vibration suppression device is fixed to and disposed on the surface of the injection target, the guide member is disposed in a state in which it is fixed to the surface of the injection target. Therefore, it is not necessary to press the guide member so that the guide member does not move when the injection needle is inserted and when the injection liquid is injected. Thus, in the above-described aspect (8), the insertion operation of the injection needle and the injection operation of the injection liquid can be efficiently performed. 
     (9) In any one of the aspects (1) to (8), the injection instrument may include the injection needle, a mounting portion on which the injection needle is mounted, and an injection instrument main body which is connected to the mounting portion via a connection portion and delivers the injection liquid to the injection needle via the connection portion and the mounting portion, and the connection portion may be bent. 
     According to the aspect (9), when the injection needle is inserted, the connection portion can be disposed to be bent upward with respect to the surface of the injection target, and the insertion operation can be performed by holding the injection instrument main body. At this time, since the injection instrument main body is more upright than when the connection portion is not bent, the nearby side is visible and the injection instrument main body is sufficiently separated from the injection target and surroundings thereof. Therefore, the hand holding the injection instrument main body coming into contact with the injection target and the surroundings thereof is curbed, safety is ensured even during use in surgery, and the injection needle can be easily inserted. 
     Advantageous Effects of Invention 
     According to the aspects of the present invention, an injection liquid can be easily injected into a shallow portion of an injection target by a simple operation. 
    
    
     
       BRIEF DESCRIPTION OF DRAWINGS 
         FIG. 1  is a diagram showing a situation when an injection instrument set according to an embodiment of the present invention is used. 
         FIG. 2  is a cross-sectional view along line A-A of a mounting portion of  FIG. 1 . 
         FIG. 3  is a side view of an injection needle of  FIG. 1 . 
         FIG. 4  is a cross-sectional view along line B-B of  FIG. 3 . 
         FIG. 5  is a plan view of a guide member of  FIG. 1 . 
         FIG. 6  is a cross-sectional view along line C-C of  FIG. 5 . 
         FIG. 7  is an enlarged view of a portion D in  FIG. 6 . 
     
    
    
     DESCRIPTION OF EMBODIMENTS 
     Hereinafter, an embodiment of the present invention will be described with reference to the drawings. 
       FIG. 1  is a diagram showing a situation when an injection instrument set according to an embodiment of the present invention is used. 
     The injection instrument set  1  of the embodiment is used for transplanting regenerated myocardial cells into a myocardium (a shallow portion)  12  of a heart (an injection target)  11 . The regenerated myocardial cells are derived from, for example, iPS cells. The myocardium  12  is a portion formed on the surface side of the heart  11 . 
     The injection instrument set  1  transplants the regenerated myocardial cells into the myocardium  12  by injecting a liquid (an injection liquid) containing the regenerated myocardial cells into the myocardium  12 . The injection instrument set  1  includes an injection instrument  2 , a guide member  7 , and an auxiliary member  8 . 
     The injection instrument  2  is an instrument for injecting an injection liquid into the myocardium  12 . The injection instrument  2  includes an injection instrument main body  3 , a connection portion  4 , a mounting portion  5 , and a plurality of (three) injection needles  6 . 
     The injection instrument main body  3  includes a syringe  31  and a plunger  32 . 
     The syringe  31  is formed in a tubular shape. The plunger  32  is fitted inside the syringe  31  from the base end side of the syringe  31 . The plunger  32  is formed inside the syringe  31  to be movable in an axial direction of the syringe  31 . An injection liquid is accommodated inside the syringe  31  between the syringe  31  and the plunger  32 . The injection liquid is discharged from a tip end of the syringe  31  by the plunger  32  being manually pressed and moved to the tip end side inside the syringe  31 . 
     The connection portion  4  connects the syringe  31  with the mounting portion  5 . The connection portion  4  is formed in a tubular shape. The connection portion  4  is formed to be bent. A base end of the connection portion  4  is connected to a tip end of the syringe  31  by a Luer taper method. The inside of the connection portion  4  communicates with the inside of the syringe  31 . The inside of the connection portion  4  is formed so that the injection liquid discharged from the syringe  31  can pass therethrough. 
     The mounting portion  5  is a portion on which the plurality of injection needles  6  are mounted. The mounting portion  5  includes a base portion  51  and a mounting portion main body  52 . 
     The base portion  51  is formed in a tubular shape. A base end of the base portion  51  is coupled to a tip end of the connection portion  4 . The base end of the base portion  51  is screwed into the tip end of the connection portion  4  via an O-ring (not shown). The inside of the base portion  51  allows the injection liquid delivered from the connection portion  4  to pass therethrough. 
     The mounting portion main body  52  is formed to protrude from the tip end side of the base portion  51 . The mounting portion main body  52  is formed in a rectangular parallelepiped shape with a radial direction of the base portion  51  as a longitudinal direction. The base end side of the plurality of injection needles  6  is mounted on the mounting portion main body  52 . The inside of each of the injection needles  6  communicates with the inside of the base portion  51 . Accordingly, the injection liquid passing through the inside of the base portion  51  can be delivered to the inside of each of the injection needles  6 . 
     The plurality of injection needles  6  are mounted in parallel on the mounting portion main body  52 . The plurality of injection needles  6  are disposed to be spaced apart from each other at substantially equal intervals. The base end side of each of the injection needles  6  is mounted on the mounting portion main body  52 . Each of the injection needles  6  is formed in a tubular shape. The inside of each of the injection needles  6  is formed so that the injection liquid delivered from the mounting portion  5  can pass therethrough. Each of the injection needles  6  is formed to be inserted into the heart  11  (inside the heart  11 ). Each of the injection needles  6  is formed so that the injection liquid inside the injection needle  6  can be injected into the heart  11  in a state in which it is inserted into the heart  11 . 
     The guide member  7  is a member for assisting an injection operation of the injection liquid by the injection instrument  2 . The guide member  7  is disposed on the surface  13  of the heart  11  (the myocardium  12 ). The guide member  7  is subjected to an anti-slip treatment on a portion thereof which comes into contact with the surface  13  of the heart  11 . The guide member  7  is detachably mounted on a stabilizer (a vibration suppression device)  15 . 
     The stabilizer  15  is fixed to and disposed on the surface  13  of the heart  11 . The stabilizer  15  includes a U-shaped adsorption portion  16 . The adsorption portion  16  is adsorbed and fixed to the surface  13  of the myocardium  12 . Thus, the stabilizer  15  curbs vibration of the heart  11 . 
     The guide member  7  is formed in a plate shape of a transparent material such as an acrylic resin. Most of the guide member  7  is detachably mounted between U-shaped side portions  161  and  161  of the adsorption portion  16  of the stabilizer  15 . A part of the guide member  7  near an outer periphery thereof is disposed on a root portion  162  of the adsorption portion  16  of the stabilizer  15 . In addition, “transparent” may mean light transmission to an extent that, for example, blood vessels and the like of the heart  11  can be visually observed through the material. 
     The auxiliary member  8  is formed in a plate shape. The auxiliary member  8  is disposed below the root portion  162  of the adsorption portion  16  of the stabilizer  15 . The auxiliary member  8  is coupled to one end of the guide member  7 . In this state, the guide member  7  and the auxiliary member  8  detachably sandwich the root portion  162  of the adsorption portion  16 . Thus, the guide member  7  is detachably mounted on the stabilizer  15  using the auxiliary member  8 . 
       FIG. 2  is a cross-sectional view along line A-A of the mounting portion of  FIG. 1 . 
     As shown in  FIG. 2 , a plurality of (three) mounting holes  53  are provided inside the mounting portion  5 . The plurality of mounting holes  53  are formed to linearly pass through the inside of the mounting portion  5  (the inside of the base portion  51  and the mounting portion main body  52 ) from the base end side to the tip end side of the mounting portion  5 . The plurality of mounting holes  53  are disposed in parallel in a radial direction of the mounting portion main body  52 . The tip end side of each of the injection needles  6  is fitted into each of the mounting holes  53 . Accordingly, the plurality of injection needles  6  are mounted on the mounting portion main body  52 . 
       FIG. 3  is a side view of the injection needle of  FIG. 1 . In addition, in  FIG. 3 , a part of the tip end side of the injection needle  6  is shown in a cross-sectional view. 
     As shown in  FIG. 3 , the injection needle  6  includes an injection needle main body  61  and a tip end portion  62 . The injection needle main body  61  is formed in a tubular shape. A plurality of discharge holes  64  are provided in a peripheral surface  63  of the injection needle main body  61 . A portion of the injection needle main body  61  in which the discharge hole  64  is formed is a portion to be disposed in the myocardium  12  when the injection needle  6  is inserted. The plurality of discharge holes  64  are spirally provided in the peripheral surface  63  in a lengthwise direction  6 A (an axial direction) of the injection needle  6 . The plurality of discharge holes  64  are formed to discharge the injection liquid accommodated in the inside  69  of the injection needle main body  61  to the myocardium  12 . 
     The tip end portion  62  is provided on the tip side of the injection needle main body  61 . The tip end portion  62  forms a tip end portion of the injection needle  6 . The tip end portion  62  is formed to be tapered from a base end to a tip end of the tip end portion  62 . A tip end  65  of the injection needle  6  is a closed blind end. 
       FIG. 4  is a cross-sectional view along line B-B of  FIG. 3 . 
     As shown in  FIG. 4 , the plurality of discharge holes  64  are disposed at equal intervals in a circumferential direction  6 B of the injection needle  6  when seen in the length direction  6 A of the injection needle  6 . Specifically, the discharge holes  64  are disposed at intervals of  120  ° in the circumferential direction  6 B of the injection needle  6 . 
       FIG. 5  is a plan view of the guide member of  FIG. 1 . The guide member  7  of  FIGS. 1 and 5  shows a part of an upper portion of the guide member  7  in which the plurality of mounting holes  53  are disposed. A planar shape of the guide member  7  is, for example, a circle or a rectangle. 
     As shown in  FIG. 5 , recessed portions  71  are provided in both side portions of the guide member  7  in a predetermined first direction  7 A (a left-right direction in  FIG. 5 ). Both recessed portions  71  and  71  are formed by cutting out upper surface side portions of both side portions. Guide passage groups  10  are respectively provided on both sides of the guide member  7  in the first direction  7 A. The guide passage groups  10  and  10  on both sides are provided on both sides of an intermediate portion  72  in the first direction  7 A which is a portion (the intermediate portion  72 ) between the recessed portions  71  and  71  of the guide member  7 . 
     Each of the guide passage groups  10  is constituted of a plurality of (three) guide passages  9 . Each of the plurality of guide passages  9  corresponds to each of the plurality of (three) injection needles  6 . Each of the plurality of guide passages  9  on both sides is provided so that the injection needle  6  can be inserted therein. The plurality of guide passages  9  on both sides are provided to extend in the first direction  7 A. The plurality of guide passages  9  are alternately disposed in a second direction  7 B (a vertical direction in  FIG. 5 ) intersecting the first direction  7 A. 
       FIG. 6  is a cross-sectional view along line C-C of  FIG. 5 . In  FIG. 6 , the heart  11  and the injection instrument  2  are illustrated by a virtual line (an alternating two dots-dashed line). 
     As shown in  FIG. 6 , each of the guide passages  9  is disposed obliquely with respect to the surface  13  of the myocardium  12 . Each of the guide passages  9  is provided to linearly pass through the inside of the intermediate portion  72  from a side surface  73  of the intermediate portion  72  of the guide member  7  in the first direction  7 A (an inner surface of the recessed portion  71  in the first direction  7 A) toward a bottom surface  75  of the guide member  7 . The bottom surface  75  of the guide member  7  is a surface which comes into contact with the surface  13  of the myocardium  12  when the guide member  7  is disposed on the surface  13  of the myocardium  12 . Each of the guide passages  9  is formed so that the injection needle  6  can be inserted from the side surface  73  side of the intermediate portion  72  and can be guided to the surface  13  of the myocardium  12 . An inclination angle of the guide passage  9  may be changed according to a thickness of the myocardium  12 . 
     A plurality of grooves  77  are provided on an outer peripheral edge portion of the bottom surface  75  of the guide member  7  as an anti-slip treatment (an anti-slip portion) which prevents the guide member  7  from being shifted on the surface  13 . The plurality of grooves  77  are formed to be arranged and disposed on the entire edge portion of the bottom surface  75 . The plurality of grooves  77  may be formed linearly or in waves. Further, the anti-slip portion may be a plurality of point-shaped protrusions other than the grooves. 
     The mounting portion main body  52  of the injection instrument  2  is formed to be disposed in the recessed portion  71  when the injection needle  6  is inserted. A tip end surface  55  of the mounting portion main body  52  is formed to come into contact with the side surface  73  of the intermediate portion  72  of the guide member  7  when an injection position of the injection needle  6  is disposed at a predetermined portion of the myocardium  12 . The tip end surface  55  of the mounting portion main body  52  and the side surface  73  of the intermediate portion  72  correspond to positioning portions of the embodiment. The injection position of the injection liquid with respect to the injection needle  6  is a portion of the injection needle main body  61  on the tip end side and is a portion of the injection needle  6  in which the plurality of discharge holes  64  are provided. The predetermined portion of the myocardium  12  is, for example, an intermediate portion of the myocardium  12  in a thickness direction. A length of the injection needle  6  is set to a length which reaches the intermediate portion of the myocardium  12  in the thickness direction when the injection needle  6  is inserted diagonally. 
       FIG. 7  is an enlarged view of a portion D in  FIG. 6 . 
     As shown in  FIG. 7 , an insertion side end portion  91  of the injection needle  6  of the guide passage  9  is formed by expanding a diameter thereof from the inner side to the outer side of the insertion side end portion  91  in an axial direction  9 A (an axial direction of the guide passage  9 ). In other words, a diameter  9 B of the insertion side end portion  91  is formed to increase from the inner side to the outer side of the insertion side end portion  91  in the axial direction  9 A. The insertion side end portion  91  is an end portion of both end portions (opening end portions on both sides) of the guide passage  9  on the side on which the injection needle  6  is inserted. 
     Next, a method of injecting an injection liquid using the injection instrument set  1  will be described. The injection liquid is accommodated inside the syringe  31  of the injection instrument main body  3 . 
     First, a user places the stabilizer  15  on the surface  13  of the heart  11  (that is, the surface  13  of the myocardium  12 ). Thus, the guide member  7  is disposed on the surface  13  of the heart  11  together with the stabilizer  15 . 
     Then, the user disposes the connection portion  4  to be bent upward with respect to the surface  13  of the heart  11  and holds the injection instrument main body  3 . Next, the user inserts the plurality of injection needles  6  into the plurality of guide passages  9  of the guide member  7  and obliquely inserts the plurality of injection needles into the inside of the myocardium  12 . 
     Next, the user brings the tip end surface  55  of the mounting portion main body  52  of the injection instrument  2  into contact with the side surface  73  of the intermediate portion  72  of the guide member  7 . Thus, the injection position of the injection liquid with respect to the injection needle  6  is disposed at a predetermined portion of the myocardium  12 . 
     Next, the user presses the plunger  32  of the injection instrument main body  3  and moves it to the tip end side inside the syringe  31 . Thus, the injection liquid is discharged from the tip end of the syringe  31 . The injection liquid discharged from the tip end of the syringe  31  is delivered to the inside  69  of each of the injection needles  6  through the inside of the connection portion  4  and the mounting portion  5 . The injection liquid delivered to the inside  69  of each of the injection needles  6  is discharged to the myocardium  12  from the plurality of discharge holes  64 . Accordingly, the injection liquid is injected into the myocardium  12 . 
     Next, an action and an effect of the injection instrument set  1  of the embodiment will be described. 
     The injection instrument set  1  of the embodiment includes the injection instrument  2  formed in a tubular shape and including an injection needle  6  which is inserted into the heart  11  as an injection target and injects an injection liquid, and the guide member  7  disposed on the surface  13  of the heart  11 . The guide passage  9  disposed obliquely with respect to the surface  13  of the heart  11  is provided in the guide member  7 . The guide passage  9  is formed to allow the injection needle  6  to be inserted and guided to the surface  13  of the heart  11 . 
     Thus, when the injection liquid is injected into the myocardium  12  which is a shallow portion of the heart  11 , the injection needle  6  is inserted into the guide passage  9  and inserted obliquely into the myocardium  12 . Further, the injection needle  6  is guided by the guide passage  9  and is obliquely inserted into the myocardium  12  by mounting the guide member  7  on the surface  13  of the heart  11 . Therefore, an insertion operation of the injection needle  6  can be stably performed. Therefore, the injection needle  6  can be easily disposed in the myocardium  12 . Therefore, the injection instrument set  1  of the embodiment can easily inject the injection liquid into the myocardium  12 . Further, since the injection needle  6  can be easily disposed in the myocardium  12 , it is possible to prevent the injection needle  6  from being inserted into the myocardium  12 . 
     In the injection instrument set  1  of the embodiment, the guide member  7  is formed of a transparent material. 
     Thus, since a state of the heart  11  can be visually observed, it is possible to inject the injection liquid while the state of the heart  11  is easily grasped. Specifically, for example, since the blood vessels or the like of the heart  11  can be visually observed through the transparent guide member  7 , it is possible to perform the injection operation of the injection liquid while the blood vessels are avoided. Therefore, the injection instrument set  1  of the embodiment can efficiently perform the injection operation of the injection liquid. In addition, when a problem such as bleeding occurs during the injection operation, it can be immediately recognized and can be dealt with promptly. 
     In the injection instrument set  1  of the embodiment, the positioning portions (the tip end surface  55  of the mounting portion main body  52  of the injection instrument  2  and the side surface  73  of the intermediate portion  72  of the guide member  7 ) which are in contact with each other when the injection needle  6  is inserted and dispose the injection position of the injection needle  6  in the myocardium  12  are provided on the injection instrument  2  and the guide member  7 . Thus, when the injection needle  6  is inserted, the injection position is reliably disposed in the myocardium  12 . Therefore, the injection instrument set  1  of the embodiment can more easily inject the injection liquid into the myocardium  12 . 
     In the injection instrument set  1  of the embodiment, the injection instrument  2  includes the plurality of injection needles  6 , and the guide member  7  has the plurality of guide passages  9  corresponding to the plurality of injection needles  6 . 
     Thus, when compared with a case in which one injection needle  6  and one guide passage  9  are provided, it is possible to inject a large amount of the injection liquid over a wide area. Therefore, the injection instrument set  1  of the embodiment can efficiently inject the injection liquid into the myocardium  12 . 
     In the injection instrument set  1  of the embodiment, the guide passage  9  extends in the first direction  7 A and is provided so that the injection needles  6  can be inserted from both sides of the guide member  7  in the predetermined first direction  7 A. The guide passages  9  on both sides are alternately disposed in the second direction  7 B intersecting the first direction  7 A. Thus, the length of the guide member  7  in the first direction  7 A can be shortened as compared with the case in which the guide passages  9  on both sides are disposed to face each other. Therefore, the injection instrument set  1  of the embodiment can have a reduced size for the guide member  7 . 
     Further, in the injection instrument set  1  of the embodiment, since the guide passages  9  are provided on both sides of the guide member  7  in the first direction  7 A, the insertion position of the injection needle  6  can be determined to be one side or the other side in the first direction  7 A according to the state of the heart  11  or the like. Therefore, the injection instrument set  1  of the embodiment can improve usability. 
     In the injection instrument set  1  of the embodiment, the tip end  65  of the injection needle  6  is formed to be closed. 
     In the injection needle  6 , the plurality of discharge holes  64  are spirally provided in the peripheral surface  63  of the portion disposed on the myocardium  12  in the lengthwise direction  6 A of the injection needle  6  when the injection needle  6  is inserted. Therefore, when the injection liquid is injected, since the injection liquid is discharged into the myocardium  12  from the plurality of discharge holes  64 , the injection liquid can be injected into a wide range of the myocardium  12 . Thus, the injection instrument set  1  of the embodiment can efficiently inject the injection liquid into the myocardium  12 . 
     In the injection instrument set  1  of the embodiment, the insertion side end portion  91  of the injection needle  6  of the guide passage  9  is formed by expanding the diameter from the inner side to the outer side of the insertion side end portion  91  in the axial direction  9 A. Thus, the insertion range of the injection needle  6  of the guide passage  9  expands. Therefore, in the injection instrument set  1  of the embodiment, the injection needle  6  can be easily inserted into the guide passage  9 . 
     In the injection instrument set  1  of the embodiment, the guide member  7  is fixed to and disposed on the surface  13  of the heart  11  and is mounted on the stabilizer  15  (the vibration suppression device) which curbs the vibration of the heart  11  in a state in which it is able to be disposed on the surface  13  of the heart  11 . Therefore, the guide member  7  is disposed on the surface  13  of the heart  11  together with the stabilizer  15  when the stabilizer  15  is disposed on the surface  13  of the heart  11 . Therefore, the user does not need to press the guide member  7  so that the guide member  7  does not move when the injection needle  6  is inserted and when the injection liquid is injected. Thus, the injection instrument set  1  of the embodiment can efficiently perform the insertion operation of the injection needle  6  and the injection operation of the injection liquid. 
     Further, in the injection instrument set  1  of the embodiment, the guide member  7  is detachably mounted on the stabilizer  15 . Therefore, during maintenance of the guide member  7  and the stabilizer  15 , maintenance can be performed in a state in which both are separated by removing the guide member  7  from the stabilizer  15 . Thus, the injection instrument set  1  of the embodiment can improve workability of the maintenance operation of the guide member  7  and the stabilizer  15 . 
     In the injection instrument set  1  of the embodiment, the injection instrument  2  includes the injection needle  6  and the mounting portion  5  on which the injection needle  6  is mounted. Further, the injection instrument  2  is connected to the mounting portion  5  via the connection portion  4  and includes the injection instrument main body  3  which delivers the injection liquid to the injection needle  6  via the connection portion  4  and the mounting portion  5 . The connection portion  4  is formed to be bent. Therefore, when the injection needle  6  is inserted, the connection portion  4  is disposed to be bent upward with respect to the surface  13  of the heart  11 , and the insertion operation is performed by holding the injection instrument main body. At this time, since the injection instrument main body  3  stands up more than when the connection portion  4  is not bent, the nearby side is visible, and the injection instrument main body  3  is sufficiently separated from the heart  11  and surroundings thereof. Thus, the hand holding the injection instrument main body  3  coming into contact with the heart  11  and the surroundings thereof is curbed, safety is ensured even during use in surgery, and the insertion operation of the injection needle  6  can be easily performed. 
     In the injection instrument set  1  of the embodiment, the groove  77  is provided in the bottom surface  75  of the guide member  7 . Therefore, when the guide member  7  is disposed on the surface  13  of the myocardium  12 , it is possible to curb slipping of the guide member  7  on the surface  13  of the myocardium  12 . Therefore, since the guide member  7  is stably disposed on the surface  13  of the myocardium  12 , it is possible to stably perform the insertion operation of the injection needle  6  and the injection operation of the injection liquid. Thus, the injection instrument set  1  of the embodiment can efficiently perform the insertion operation of the injection needle  6  and the injection operation of the injection liquid. 
     Although the embodiment of the present invention has been described in detail with reference to the drawings, the specific constitution is not limited to the embodiment, and design changes to the extent that the gist of the present invention is not deviated from are included in the present invention. 
     In the injection instrument set  1  of the embodiment, although the insertion side end portion  91  of the guide passage  9  is formed by expanding the diameter thereof, the insertion side end portion  91  may be formed by increasing the diameter using a separate member. 
     Specifically, for example, a member having a tubular fitting portion in the guide passage  9  can be used as the separate member. The fitting portion is detachably fitted to the insertion side end portion  91  of the guide passage  9  and is formed so that the injection needle  6  can be inserted therein. The insertion side end portion of the injection needle  6  of the fitting portion is formed by expanding a diameter thereof. Therefore, it is possible to easily insert the injection needle  6  into the fitting portion. Thus, the injection needle  6  can be easily inserted into the guide passage  9  by inserting the injection needle  6  into the guide passage  9  via the fitting portion. 
     In the injection instrument set  1  of the embodiment, although the guide member  7  is mounted on the stabilizer  15 , the guide member  7  does not necessarily have to be mounted on the stabilizer  15 . 
     In addition, for example, a grip portion which can be gripped by the user may be provided on the upper surface of the guide member  7 . In this case, the guide member  7  is disposed on the surface  13  of the heart  11 , and the guide member  7  is pressed by gripping the grip portion in this state. Thus, since it is possible to curb movement of the guide member  7 , the insertion operation of the injection needle  6  and the injection operation of the injection liquid can be efficiently performed. 
     In addition, it is possible to replace components in the above-described embodiment with well-known components as appropriate without departing from the spirit of the present invention, and the above-described embodiment and modified examples may be appropriately combined. 
     REFERENCE SIGNS LIST 
       1  Injection instrument set 
       2  Injection instrument 
       3  Injection instrument main body 
       4  Connection portion 
       5  Mounting portion 
       6  Injection needle 
       6 A Lengthwise direction 
       7  Guide member 
       7 A First direction 
       7 B Second direction 
       9  Guide passage 
       9 A Axial direction 
       11  Heart (injection target) 
       12  Myocardium (shallow portion) 
       13  Surface of heart (surface of injection target) 
       15  Stabilizer (vibration suppression device) 
       55  Tip end surface of mounting portion main body of injection instrument (positioning portion) 
       63  Peripheral surface 
       64  Discharge hole 
       65  Tip end 
       73  Side surface of intermediate portion of guide member (positioning portion) 
       91  Insertion side end portion