Patent Publication Number: US-2023148930-A1

Title: Biosensor

Description:
TECHNICAL FIELD 
     The present invention relates to a biosensor. 
     BACKGROUND ART 
     In a medical institution such as a hospital or a clinic, a nursing facility, or a home, a biosensor for measuring biological information such as an electrocardiogram, pulse wave, electroencephalogram, or myoelectricity is used. The biosensor is provided with a bio-electrode for acquiring biological information of a subject by contacting with a living body, and when measuring the biological information, the biosensor is affixed to a skin of the subject, and the bio-electrode is brought into contact with the skin of the subject. The biological information is measured by acquiring an electric signal relating to the biological information with a bio-electrode. 
     As such a biosensor, for example, a patch-type biological device which includes a wiring board stored in a storage space defined by an upper exterior body and a lower exterior body, and a coin battery mounted on the wiring board, power being supplied from the coin battery to a wireless communication unit, and data acquired by the wireless communication unit being transmitted, is disclosed (See, for example, Patent Document 1). 
     PRIOR ART DOCUMENT 
     Patent Document 
     
         
         [Patent Document 1] Japanese Unexamined Patent Application Publication No. 2019-203881 
       
    
     SUMMARY OF THE INVENTION 
     Problems to be Solved by the Invention 
     In a biosensor having a battery such as a coin battery or a controller for controlling an operation of the biosensor inside, as in the case of the conventional patch-type biosensor, when the biosensor is used, there is a possibility that the resistance of a conductive member such as a wiring arranged between the battery and the controller rises due to contact with pressure to a skin of the subject, movement of the living body (body movement), or the like, and the voltage supplied from the battery drops. In particular, when the supply voltage from the battery falls below an operable voltage of the controller, there is a case where the operation of the biosensor is stopped and the biological information cannot be measured. 
     An object of the present invention is to provide a biosensor in which a voltage can be stably supplied from a battery to a controller. 
     Means for Solving the Problem 
     According to an aspect of the present invention, a biosensor, which operates by power supplied from a battery, includes an electrode portion positioned on at least a side of one terminal of the battery; and a conductive adhesive tape having conductivity provided between the one terminal and the electrode portion, a fluctuation width of a resistance value of the conductive adhesive tape being 1.60Ω or less in absolute value when an iron ball having a weight of 33 g is dropped vertically from a height of 30 cm to apply a load to a surface of the conductive adhesive tape. 
     Effect of the Invention 
     According to an aspect of the present invention, in the biosensor a voltage can be stably supplied from the battery to the controller. 
    
    
     
       BRIEF DESCRIPTION OF DRAWINGS 
         FIG.  1    is a perspective view showing a configuration of a biosensor according to an embodiment of the present invention. 
         FIG.  2    is an exploded perspective view of  FIG.  1   . 
         FIG.  3    is a cross-sectional view cut along I-I in  FIG.  1   . 
         FIG.  4    is a plan view showing a configuration of a sensor portion. 
         FIG.  5    is an exploded perspective view of a part of the sensor portion of  FIG.  4   . 
         FIG.  6    is an explanatory diagram showing a layout of the sensor portion of  FIG.  4   . 
         FIG.  7    is a partial cross-sectional view cut along II-II in  FIG.  4   . 
         FIG.  8    is a diagram showing an example of another configuration of a first conductive adhesive tape and a second conductive adhesive tape. 
         FIG.  9    is a diagram showing an example of yet another configuration of the first conductive adhesive tape and the second conductive adhesive tape. 
         FIG.  10    is an explanatory diagram showing a state in which the biosensor is affixed to a skin of a living body (subject). 
         FIG.  11    is an explanation diagram illustrating a three-point bending test. 
         FIG.  12    is a diagram showing a relationship between time and voltage in the biosensor of Example 1. 
         FIG.  13    is a diagram showing a relationship between time and voltage in the biosensor of Example 2. 
         FIG.  14    is a diagram showing a relationship between time and voltage in the biosensor of Example 3. 
         FIG.  15    is a diagram showing a relationship between time and voltage in the biosensor of Example 4. 
         FIG.  16    is a diagram showing a relationship between time and voltage in the biosensor of Example 5. 
         FIG.  17    is a diagram showing a relationship between time and voltage in the biosensor of Example 6. 
         FIG.  18    is a diagram showing a relationship between time and voltage in the biosensor of Comparative example 1. 
         FIG.  19    is a diagram showing a relationship between time and voltage in the biosensor of Comparative example 2. 
         FIG.  20    is a diagram showing a relationship between time and voltage in the biosensor of Comparative example 3. 
     
    
    
     MODE FOR CARRYING OUT THE INVENTION 
     In the following, embodiments of the present disclosure will be described in detail. To facilitate understanding of the description, in each drawing, to the same elements, the same reference numeral will be assigned, and a duplicate explanation may be omitted. Moreover, a scale of each member in the drawings may be different from the actual scale. In the specification of the present application, a three-dimensional orthogonal coordinate system in three axes (in an X-axis direction, a Y-axis direction, and a Z-axis direction) is used. A transverse direction of the biosensor is set to be the X-axis direction, the longitudinal direction of the biosensor is set to be the Y-axis direction, and the height direction (in the thickness direction) of the biosensor is set to be the Z-axis direction. A direction opposite to the side (sticking side) on which the biosensor is affixed to the living body (subject) is set to be a +Z-axis direction, and the side (sticking side) on which the biosensor is affixed to the living body (subject) is set to be a −Z-axis direction. In the following description, for convenience of illustration, the +Z-axis side will be referred to as an upper side or above, and the −Z-axis side will be referred to as a lower side or below. However, they do not represent a universal vertical relationship. In this specification, a hyphen “-” indicating a numerical value range means to include numerical values described before and after the hyphen as the lower limit value and the upper limit value, unless otherwise stated. 
     &lt;Biosensor&gt; 
     A biosensor according to the present embodiment will be described. In the present embodiment, as an example, a case of a patch-type biosensor brought into contact with a living body to measure biological information will be described. The term “living body” includes a human body (human) and an animal, such as a cow, a horse, a pig, a chicken, a dog, and a cat. The biosensor is affixed to a part of the living body (for example, skin, scalp, or forehead). The biosensor can be suitably used for a living body, especially a human body. 
       FIG.  1    is a perspective view illustrating a configuration of a biosensor according to the present embodiment.  FIG.  2    is an exploded perspective view of  FIG.  1   .  FIG.  3    is a cross-sectional view of I-I in  FIG.  1   . As shown in  FIG.  1   , the biosensor  1  is a plate-like (sheet-like) member that is approximately elliptically formed in a plan view. As shown in  FIGS.  2  and  3   , the biosensor  1  includes a biological adhesive layer  10 , a foamed sheet  20 , a casing  30 , an electrode  40 , and a sensor portion  50 , and is constituted by laminating the biological adhesive layer  10 , the foamed sheet  20 , and the casing  30  in this order from the biological adhesive layer  10  side toward the casing  30  side. The biological adhesive layer  10 , the foamed sheet  20 , and the casing  30  have substantially the same outer shape in a plan view. The electrode  40  is provided on the surface of the biological adhesive layer  10  on the side of affixing to the skin  2  (−Z-axis direction). The sensor portion  50  is disposed on the biological adhesive layer  10  and is housed in a storage space S formed of the foamed sheet  20  and the casing  30 . 
     [Biological Adhesive Layer] 
     As shown in  FIG.  3   , the biological adhesive layer  10  includes a substrate  11 , a sticking adhesive layer  12 , and a sensor adhesive layer  13 . 
     (Substrate) 
     As shown in  FIG.  3   , the substrate  11  is provided on the sticking adhesive layer  12 , so that a surface on the side of the foamed sheet  20  and the casing  30  is exposed. The outer shape of both sides of the substrate  11  in the width direction (X-axis direction) is substantially the same as the outer shape of both sides of the foamed sheet  20  and the casing  30  in the width direction (X-axis direction). The length (Y-axis direction) of the substrate  11  is formed shorter than the length (Y-axis direction) of the foamed sheet  20  and the casing  30 . 
     The substrate  11  can be formed of a flexible resin having appropriate elasticity, flexibility, and toughness. As a material for forming the substrate  11 , for example, a thermoplastic resin including a polyester-based resin, such as polyethylene terephthalate (PET), polybutylene terephthalate (PBT), polytrimethylene terephthalate, polyethylene naphthalate, and polybutylene naphthalate; an acrylic-based resin, such as polyacrylic acid, polymethacrylic acid, polymethyl acrylate, polymethyl methacrylate (PMMA), polyethyl methacrylate, and polybutyl acrylate; a polyolefin-based resin, such as polyethylene and polypropylene; a polystyrene-based resin, such as polystyrene, imide-modified polystyrene, acrylonitrile-butadiene styrene (ABS) resin, imide-modified ABS resin, styrene-acrylonitrile copolymerization (SAN) resin, and acrylonitrile-ethylene-propylene-diene styrene (AES) resin; a polyimide-based resin; a polyurethane-based resin; a silicone-based resin; and a polyvinyl chloride-based resin, such as polyvinyl chloride resin, and vinyl chloride-vinyl acetate copolymer resin, may be used. Among them, a polyolefin-based resin and PET are preferably used. The above-described thermoplastic resins are waterproof (with low moisture permeability). Thus, when the substrate  11  is formed of the above-described thermoplastic resins, it is possible to prevent perspiration or water vapor generated from the skin  2  from entering a flexible substrate  51  side of the sensor portion  50  through the substrate  11  in the state where the biosensor  1  is affixed to the skin  2  of the living body. 
     Since the sensor portion  50  is disposed on the upper surface of the substrate  11 , the substrate  11  is preferably formed in a flat plate shape. 
     The thickness of the substrate  11  can be selected appropriately and optionally, and is for example, preferably 1 μm-300 μm, more preferably 5 μm-100 μm, and even more preferably 10 μm-50 μm. 
     (Sticking Adhesive Layer) 
     As shown in  FIG.  3   , the sticking adhesive layer  12  is provided on the lower surface of the substrate  11  on the sticking side (−Z-axis direction), and is a layer that is brought into contact with the living body. The sticking adhesive layer  12  preferably has moisture permeability. Water vapor or the like generated from the skin  2 , to which the biosensor  1  is affixed, can be released to the foamed sheet  20  through the sticking adhesive layer  12 . Further, since the foamed sheet  20  has a bubble structure as will be described later, water vapor can be discharged to the outside of the biosensor  1  through a casing adhesive layer  22 . Thus, it is possible to prevent perspiration or water vapor from accumulating at the interface between the skin  2  on which the biosensor  1  is mounted and the sticking adhesive layer  12 . As a result, it is possible to prevent the adhesive force of the sticking adhesive layer  12  from being weakened by the moisture accumulated at the interface between the skin  2  and the sticking adhesive layer  12 , and peeling of the biosensor  1  from the skin can be suppressed. 
     The sticking adhesive layer  12  preferably has pressure sensitive adhesiveness. Since the sticking adhesive layer  12  has pressure sensitive adhesiveness, the biosensor  1  can be easily affixed to the skin  2  by pressing the biosensor  1  against the skin  2  of the living body. 
     The material of the sticking adhesive layer  12  is not particularly limited, as long as the material has a pressure-sensitive adhesiveness. The material includes a biocompatible material, and the like. Suitable materials forming the sticking adhesive layer  12  include, for example, an acrylic pressure-sensitive adhesive, and a silicone pressure-sensitive adhesive. The material preferably includes an acrylic pressure-sensitive adhesive. 
     The acrylic pressure-sensitive adhesive preferably includes an acrylic polymer as a main component. The acrylic polymer can function as a pressure sensitive adhesive component. For the acrylic polymer, a polymer obtained by polymerizing monomer components including a (meth)acrylic ester, such as isononyl acrylate or methoxyethyl acrylate, as a main component, and a monomer that can be copolymerized with (meth)acrylic ester, such as acrylic acid, as an optional component, may be used. 
     Preferably, the acrylic pressure-sensitive adhesive further includes a carboxylic acid ester. The carboxylic acid ester functions as a pressure-sensitive adhesive force regulator to reduce a pressure-sensitive adhesive force of the acrylic polymer to adjust the pressure-sensitive adhesive force of the sticking adhesive layer  12 . For the carboxylic acid ester, a carboxylic acid ester compatible with acrylic polymers may be used. For the carboxylic acid ester, a trifatty acid glyceryl or the like may be used. 
     The acrylic pressure-sensitive adhesive may contain a crosslinking agent, as necessary. The crosslinking agents are cross-linking components that cross-link acrylic polymers. Suitable crosslinking agents include, for example, a polyisocyanate compound (a polyfunctional isocyanate compound), an epoxy compound, a melamine compound, a peroxide compound, a urea compound, a metal alkoxide compound, a metal chelate compound, a metal salt compound, a carbodiimide compound, an oxazoline compound, an aziridine compound, and an amine compound. Among the above-described compounds, the polyisocyanate compound is preferable. The above-described crosslinking agents may be used singly, or a combination of two or more crosslinking agents may be used. 
     The sticking adhesive layer  12  preferably has excellent biocompatibility. For example, when the sticking adhesive layer  12  is subjected to a keratin peeling test, a keratin peeling area ratio is preferably 0%-50%, and more preferably 1%-15%. When the keratin peeling area ratio is 0%-50%, the load on the skin  2  can be suppressed even when the sticking adhesive layer  12  is affixed to the skin  2 . 
     The moisture permeability of the sticking adhesive layer  12  is preferably 300 g/m 2 ·day or more, more preferably 600 g/m 2 ·day or more, and even more preferably 1,000 g/m 2 ·day or more. Moreover, the moisture permeability of the sticking adhesive layer  12  is 10,000 g/m 2 ·day or less. If the moisture permeability of the sticking adhesive layer  12  is 300 g/m 2 ·day or more, perspiration or the like generated from the skin  2  can be transmitted appropriately from the substrate  11  to the outside even when the sticking adhesive layer  12  is affixed to the skin  2 , thereby the load to the skin  2  can be reduced. 
     The thickness of the sticking adhesive layer  12  can be appropriately selected. The thickness is preferably 10 μm-300 μm. When the thickness of the sticking adhesive layer  12  is 10 μm-300 μm, the biosensor  1  can be made thinner. 
     The sensor adhesive layer  13  is stuck to the upper surface of the substrate  11  and is a layer for bonding the substrate  11  to the flexible substrate  51  of the sensor portion  50 . The material for forming the sensor adhesive layer  13  is preferably a material having pressure-sensitive adhesiveness, the same material as the sticking adhesive layer  12  can be used, and an acrylic pressure-sensitive adhesive is preferably used. 
     The thickness of the sensor adhesive layer  13  can be set optionally and appropriately, and is preferably 10 μm-300 μm. When the thickness of the sensor adhesive layer  13  is 10 μm-300 μm, the biosensor  1  can be made thinner. 
     [Foamed Sheet] 
     The foamed sheet  20  has a foamed sticking layer  21  and a casing adhesive layer  22  provided on the upper surface thereof. 
     (Foamed Sticking Layer) 
     As shown in  FIG.  3   , the foamed sticking layer  21  includes a foamed substrate  211  and a substrate adhesive layer  212  provided on the surface of the foamed substrate  211  on the living body side (−Z-axis direction). When the foamed substrate  211  and the sticking adhesive layer  12  are sufficiently bonded, the foamed sticking layer  21  may not include the substrate adhesive layer  212 , and the foamed substrate  211  may be bonded to the sticking adhesive layer  12 . 
     ((Foamed Substrate)) 
     The foamed substrate  211  can be formed using a foam having a foaming structure of open cell, closed cell, or semi-closed cell having flexibility, waterproofness, and moisture permeability. Thereby, water vapor due to perspiration or the like generated from the living body to which the biosensor  1  is affixed can be discharged to the outside of the biosensor  1  through the foamed substrate  211 . 
     As the material for forming the foamed substrate  211 , for example, a thermoplastic resin such as a polyurethane resin, a polystyrene resin, a polyolefin resin, a silicone resin, an acrylic resin, a vinyl chloride resin, or a polyester resin may be used. Among the above-described resins, a polyester resin is preferable, and PET is suitably used. 
     The thickness of the foamed substrate  211  can be suitably selected, and can be, for example, 0.5 mm-1.5 mm. 
     ((Substrate Adhesive Layer)) 
     As shown in  FIG.  3   , the substrate adhesive layer  212  is stuck to the lower surface of the foamed substrate  211  and has a function of bonding the substrate  11  to the foamed substrate  211 . 
     The substrate adhesive layer  212  preferably has moisture permeability. Water vapor or the like generated from the skin  2  to which the biosensor  1  is affixed can be released to the foamed substrate  211  through the substrate adhesive layer  212 . Further, since the foamed substrate  211  has a bubble structure as described above, water vapor can be discharged to the outside of the biosensor  1  through the casing adhesive layer  22 . Thus, it is possible to prevent perspiration or water vapor from accumulating at the interface between the skin  2  on which the biosensor  1  is mounted and the sticking adhesive layer  12 . As a result, it is possible to prevent the adhesive force of the sticking adhesive layer  12  from being weakened by the moisture accumulated at the interface between the skin  2  and the sticking adhesive layer  12 , and the biosensor  1  can be prevented from peeling off from the skin  2 . 
     The material for forming the substrate adhesive layer  212  is preferably a material having pressure-sensitive adhesiveness, and the same material as that of the sticking adhesive layer  12  can be used. As the material for forming the substrate adhesive layer  212 , an acrylic pressure-sensitive adhesive is preferably used. 
     The moisture permeability of the substrate adhesive layer  212  is preferably 1 g/m 2 ·day or more, more preferably 10 g/m 2 ·day or more. The moisture permeability of the substrate adhesive layer  212  is 10,000 g/m 2 ·day or less. When the moisture permeability of the substrate adhesive layer  212  is 10 g/m 2 ·day or more, when the sticking adhesive layer  12  is affixed to the skin  2 , perspiration or the like transmitted from the biological adhesive layer  10  can be permeated to the outside, so that the load on the skin  2  can be suppressed. 
     The thickness of the substrate adhesive layer  212  can be set appropriately and as desired, and is preferably 10 μm-300 μm. When the thickness of the substrate adhesive layer  212  is 10 μm-300 μm, the thickness of the biosensor  1  can be reduced. 
     (Casing Adhesive Layer) 
     As shown in  FIG.  3   , the casing adhesive layer  22  is provided in a state of being stuck to the upper surface of the foamed substrate  211 . The casing adhesive layer  22  is stuck at a position corresponding to a flat surface on the sticking side (−Y-axis direction) of the casing  30  on the upper surface of the foamed substrate  211 , and has a function of bonding the foamed substrate  211  to the casing  30 . 
     As the material for forming the casing adhesive layer  22 , a silicon-based adhesive, a silicon tape or the like can be used. 
     The casing adhesive layer  22  preferably has moisture permeability. Since the foamed substrate  211  has an open cell structure, water vapor entering through the casing adhesive layer  22  can be discharged to the outside of the biosensor  1 . 
     The thickness of the casing adhesive layer  22  can be set appropriately, and is, for example, 0.5 mm-1.5 mm. 
     The humidity permeability of the casing adhesive layer  22  is preferably 65 g/m 2 ·day-4,000 g/m 2 ·day, more preferably 90 g/m 2 ·day-2,000 g/m 2 ·day, even more preferably 800 g/m 2 ·day-1,700 g/m 2 ·day, and most preferably 850 g/m 2 ·day-1,660 g/m 2 ·day. If the moisture permeability of the casing adhesive layer  22  is within the above preferred range, the stress at the interface between the skin  2  and the sticking adhesive layer  12  provided on the surface of the substrate  11  on the sticking side (−Z-axis direction) can be relaxed, so that the peeling of the biosensor  1  from the skin  2  can be suppressed. 
     (Casing) 
     As shown in  FIG.  3   , the casing  30  is stuck to the upper surface of the foamed sheet  20 . The casing  30  has a substantially dome-shaped projection portion  31  protruding in the height direction (+Z-axis direction) of the biosensor  1  at the center in the longitudinal direction (Y-axis direction). The lower surface of the casing  30  (the surface on the sticking side) is formed flat. A storage space S for storing the sensor portion  50  is formed inside (on the sticking side) of the projection portion  31 . 
     As the material for forming the casing  30 , a material having flexibility such as silicone rubber, fluororubber, or urethane rubber can be used. The material protects the sensor portion  50  arranged in the storage space S of the casing  30 , and absorbs an impact applied to the biosensor  1  from the upper surface side, to reduce the impact applied to the sensor portion  50 . 
     The thickness of the top side and the side wall of the projection portion  31  of the casing  30  is preferably greater than the thickness of the flat portions  32   a  and  32   b  provided on both ends in the longitudinal direction L of the casing  30 . Thus, the flexibility of the projection portion  31  can be made lower than that of the flat portions  32   a  and  32   b , and the sensor portion  50  can be protected from an external force applied to the biosensor  1 . 
     Preferably, the thickness of the top side and side wall of the projection portion  31  is 1.5 mm-3 mm, and the thickness of the flat portions  32   a  and  32   b  is 0.5 mm-1 mm. 
     Since the thin flat portions  32   a  and  32   b  are more flexible than the projection portion  31 , when the biosensor  1  is affixed to the skin  2 , the flat portions can be easily deformed following deformation of the surface of the skin  2  caused by body movement such as stretching, bending and twisting. Thus, the stress applied to the flat portions  32   a  and  32   b  when the surface of the skin  2  is deformed can be relaxed, and the biosensor  1  can be made unlikely to peel off from the skin  2 . 
     The outer peripheral portions of the flat portions  32   a  and  32   b  preferably have a shape in which the thickness gradually decreases toward the end. Thus, the flexibility of the outer peripheral portions of the flat portions  32   a  and  32   b  can be further enhanced, and the wearing feeling when the biosensor  1  is affixed to the skin  2  can be improved as compared with the case where the thickness of the outer peripheral portions of the flat portions  32   a  and  32   b  is not reduced. 
     (Electrode) 
     As shown in  FIG.  3   , the electrode  40  is stuck to the lower surface of the sticking adhesive layer  12  provided on the lower surface of the substrate  11  on the sticking side (−Z-axis direction). When the biosensor  1  is affixed to the skin  2 , the electrode  40  is brought into contact with the skin  2 , so that a biological signal can be detected. The biological signal is, for example, an electric signal representing an electrocardiogram, an electroencephalogram, or a pulse. Note that the electrode  40  may be embedded in the substrate  11  in a state of being exposed contactably with the skin. 
     The electrode  40  can be formed by using an electrode sheet in which a cured product of a conductive composition containing a conductive polymer and a binder resin, a metal, an alloy, or the like is formed in a sheet shape. 
     For the conductive polymer, for example, a polythiophene-based conductive polymer, a polyaniline-based conductive polymer, a polypyrrole-based conductive polymer, a polyacetylene-based conductive polymer, a polyphenylene-based conductive polymer and derivatives thereof, and a complex thereof may be used. The above-described conductive polymers may be used singly, or a combination of two or more conductive polymers may be used. Among them, a complex obtained by doping polyaniline as a dopant to polythiophene is preferably used. Among the complexes of polythiophene and polyaniline, PEDOT/PSS obtained by doping polystyrene sulfonic acid (poly4-styrene sulfonate; PSS) to poly3,4-dioxythiophene (PEDOT), is more preferably used because of a lower contact impedance with the living body and the high electric conductivity. 
     Further, the electrode  40  may be embedded in the lower surface of the sticking adhesive layer  12  in a state of being exposed to the sticking adhesive layer  12  contactably with the living body. 
     The electrode  40  may have a plurality of through holes on the contact surface with the skin  2 . Thereby, the electrode  40  can expose the sticking adhesive layer  12  to the sticking side from the through holes in the state of being stuck to the sticking adhesive layer  12 , so that adhesiveness of the electrode  40  with the skin  2  can be enhanced. 
     (Sensor Portion) 
       FIG.  4    is a plan view illustrating a configuration of the sensor portion  50 , and  FIG.  5    is an exploded perspective view of a part of the sensor portion  50 . The dashed line in  FIG.  4    represents the outer shape of the casing  30 . As shown in  FIGS.  4  and  5   , the sensor portion  50  includes a flexible substrate  51  on which various components for acquiring biological information are mounted, a sensor body  52 , wirings  53   a  and  53   b  connected to the sensor body  52  in the longitudinal direction of the sensor body  52 , a battery  54 , a positive electrode pattern (first electrode portion)  55 , a negative electrode pattern (second electrode portion)  56 , and a conductive adhesive tape  57 . Between a pad portion  522   a  and a pad portion  522   b  of the sensor portion  50 , the positive electrode pattern  55 , the conductive adhesive tape  57 , the battery  54 , the conductive adhesive tape  57 , and the negative electrode pattern  56  are laminated in this order from the pad portion  522   a  side to the pad portion  522   b  side. In the present embodiment, the positive terminal of the battery  54  is set to be in the −Z-axis direction and the negative terminal is set to be in the +Z-axis direction. However, the positive terminal and the negative terminal may be reversed, i.e. the positive terminal may be in the +Z-axis direction and the negative terminal may be in the −Z-axis direction. 
     The flexible substrate  51  is made of a resin, and the flexible substrate  51  is integrally formed with the sensor body  52  and the wirings  53   a  and  53   b.    
     An end of each of the wirings  53   a  and  53   b  is connected to the electrode  40 , as shown in  FIG.  3   . As shown in  FIG.  4   , the other end of the wiring  53   a  is connected to a switch or the like mounted to a component mounting portion  521  along the outer periphery of the sensor body  52 . The other end of the wiring  53   b  is connected to a switch or the like mounted on the component mounting portion  521  in the same manner as the wiring  53   a . The wirings  53   a  and  53   b  may be formed on any of wiring layers on the front surface side and the rear surface side of the flexible substrate  51 . 
     As shown in  FIG.  4   , the sensor body  52  includes the component mounting portion  521  that is a controller and includes the battery mounting portion  522 . 
     The component mounting portion  521  includes various components mounted on the flexible substrate  51 , such as a CPU and an integrated circuit for processing biological signals acquired from a living body to generate biological signal data; a switch for activating the biosensor  1 ; a flash memory for storing the biological signals; or a light emitting element. Examples of circuits using various components will be omitted. The component mounting portion  521  is operated by power supplied from the battery  54  mounted on the battery mounting portion  522 . 
     The component mounting portion  521  by wire or wirelessly communicates with an external device such as an operation checking device for checking an initial operation, or a readout device for reading biological information from the biosensor  1 . 
     The battery mounting portion  522  supplies power to the integrated circuit mounted on the component mounting portion  521 . The battery  54  is mounted on the battery mounting portion  522 , as shown in  FIG.  5   . 
       FIG.  6    is an explanatory diagram showing a layout of the sensor portion  50  shown in  FIG.  4   . As shown in  FIG.  6   , the battery mounting portion  522  is disposed between the wiring  53   a  and the component mounting portion  521 , and includes the pad portions  522   a  and  522   b  and a constriction portion  522   c.    
     As shown in  FIG.  6   , the pad portion  522   a  is provided between the wiring  53   a  and the component mounting portion  521 , located on the positive terminal side of the battery  54 , and has the positive electrode pattern  55  to which the positive terminal is connected. 
     As shown in  FIG.  6   , the pad portion  522   b  is provided separated from the pad portion  522   a  by a predetermined distance along a direction orthogonal to the longitudinal direction (in the vertical direction in  FIG.  3   ) with respect to the pad portion  522   a . The pad portion  522   b  is located on the negative terminal (second terminal) side of the battery  54  and has the negative electrode pattern  56  to which the negative terminal is connected. 
     As shown in  FIG.  6   , the constriction portion  522   c  is disposed between the pad portions  522   a  and  522   b  to connect the pad portions  522   a  and  522   b  to each other. 
     As shown in  FIG.  5   , the battery  54  is arranged between the positive and negative electrode patterns  55  and  56 . The battery  54  has positive and negative terminals. For the battery  54 , a publicly-known battery may be used. The battery  54  may be a coin-type battery, such as CR2025. 
     The positive electrode pattern  55  is located on the positive terminal side of the battery  54  and is connected to the positive terminal. As shown in  FIG.  6   , the positive electrode pattern  55  has a rectangular shape with chamfered corners. 
     The negative electrode pattern  56  is located on the negative terminal side of the battery  54  and is connected to the negative terminal. As shown in  FIG.  6   , the negative electrode pattern  56  has a shape substantially corresponding to the size of the circular shape of the negative terminal of the battery  54 . The diameter of the negative electrode pattern  56  is, for example, equal to the diameter of the battery  54  and approximately equal to the diagonal length of the positive electrode pattern  55 . 
     The conductive adhesive tape  57  is a conductive adhesive that is disposed between the battery  54  and the positive electrode pattern  55  and also is disposed between the battery  54  and the negative electrode pattern  56 . The conductive adhesive tape may also generally be referred to as a conductive adhesive sheet, a conductive adhesive film, or the like. 
     In the conductive adhesive tape  57 , when an iron ball having a weight of 33 g is dropped vertically from a height of 30 cm to apply a load to the surface, the fluctuation width of the resistance value is set to be 1.60Ω or less in absolute value. The inventor of the present application has focused on that by suppressing the fluctuation of the resistance value when a predetermined load is applied to the surface of the conductive adhesive tape  57 , a change in a size of a conductive path can be suppressed even if a load is applied to the conductive adhesive tape  57 . The present inventor has found that when the fluctuation width of the resistance value of the conductive adhesive tape  57  is 1.60Ω or less in absolute value, the change in the size of the conductive path can be suppressed even if the predetermined load is applied to the conductive adhesive tape  57 , and a stable conduction can be secured. 
     The conductive adhesive tape  57  preferably has a bending load per unit bending deflection of 0.035 N/cm or less. When the rigidity of the conductive adhesive tape  57  for joining the battery to the positive electrode pattern  55  or to the negative electrode pattern  56  is reduced and the bending load per unit bending deflection is a predetermined value or less, a change in a size of a conductive path can be suppressed even if a load is applied to the conductive adhesive tape  57 , resistance fluctuation of the conductive adhesive tape  57  is suppressed and a stable conduction can be secured. 
     Here, the bending load per unit bending deflection can be obtained by calculating a bending load per unit bending deflection using the three-point bending test in accordance with JIS K7171. Specifically, a conductive adhesive tape  57  having a predetermined size (for example, 2 cm in width x 15 cm in length) is prepared. The conductive adhesive tape  57  is reinforced by sandwiching with PET films (thickness: 38 μm) from both sides. Thus, a laminate in which the conductive adhesive tape  57  is sandwiched by the PET film is produced. The three-point bending test is performed using the laminate, and the deflection up to 1 cm of a deflection-load curve with the deflection (unit: cm) in the X-axis and the load (unit: N) in the Y-axis is regarded as an initial inclination, and the inclination of the laminate is calculated. The obtained inclination of the laminate is obtained as a bending load per unit bending deflection of the conductive adhesive tape  57 . When a plurality of laminates (for example, 9) are produced, the bending load per unit bending deflection may be an average value of bending loads per unit bending deflection of the plurality of laminates (for example, 9). It should be noted that the distance between the two fulcrums where the conductive adhesive tape  57  is to be installed and the lowering (compression) speed of the indenter can be appropriately selected in accordance with the size of the laminate or the like, for example, when the size of the conductive adhesive tape  57  is 2 cm in width x 15 cm in length, the distance between the fulcrums is set to 5 cm and the compression speed is set to 1 cm/min. 
     The conductive adhesive tape  57  includes a first conductive adhesive tape  57 A disposed between the positive terminal of the battery  54  and the positive electrode pattern  55 , and a second conductive adhesive tape  57 B disposed between the negative terminal of the battery  54  and the negative electrode pattern  56 . In the following description, the first conductive adhesive tape  57 A and the second conductive adhesive tape  57 B may be collectively referred to simply as the conductive adhesive tape  57 . 
       FIG.  7    is a partial cross-sectional view of II-II in  FIG.  4   . As shown in  FIG.  7   , the first conductive adhesive tape  57 A is provided between the positive terminal of the battery  54  and the positive electrode pattern  55 , and electrically connects the positive terminal and the positive electrode pattern  55 . The second conductive adhesive tape  57 B is provided between the negative terminal of the battery  54  and the negative electrode pattern  56 , and electrically connects the second terminal and the negative electrode pattern  56 . 
     The first conductive adhesive tape  57 A is composed of an adhesive layer  71 A, and the second conductive adhesive tape  57 B is composed of an adhesive layer  71 B. Both the first conductive adhesive tape  57 A and the second conductive adhesive tape  57 B are so-called double-sided adhesive type conductive adhesive tapes in which both surfaces of the adhesive layers  71 A and  71 B are adhesive surfaces. The surfaces of the adhesive layers  71 A and  71 B may be referred to as adhesive surfaces. The first conductive adhesive tape  57 A and the second conductive adhesive tape  57 B are so-called substrate-less conductive double-sided adhesive tapes which are not provided with a conductive substrate such as a metal foil. 
     [Adhesive Layer] 
     The adhesive layers  71 A and  71 B have conductivity (electric conductivity) while providing adhesive surfaces of the conductive adhesive tapes. When the adhesive surfaces of the adhesive layers  71 A and  71 B are adhered to an adherend such as a conductor, electric conduction between the adherend and the adhesive layers  71 A and  71 B is ensured. 
     As shown in  FIG.  7   , the adhesive layers  71 A and  71 B include an adhesive resin  711  and conductive fine particles (conductive fillers)  712 . The adhesive layers  71 A and  71 B may contain other components (additives) to the extent that the purpose of the conductive adhesive tape  57  is not impaired. 
     The thickness of the adhesive layers  71 A and  71 B is preferably 20 μm-80 μm, more preferably 30 μm-70 μm, and even more preferably 35 μm-60 μm. When the thickness of the adhesive layers  71 A and  71 B is within the above preferred range, the conductive adhesive tape  57  can be made thin, so that flexibility can be enhanced. 
     (Adhesive Resin) 
     The adhesive resin  711  has a function of securing the adhesive force of the adhesive layers  71 A and  71 B. The adhesive resin  711  is formed using an adhesive polymer. Examples of the adhesive polymer include an acrylic polymer, a silicone polymer, a urethane polymer, a rubber polymer, a vinyl alkyl ether polymer, a polyester polymer, a polyamide polymer, a fluorine polymer, and an epoxy polymer. Among the above-described polymers, an acrylic polymer is preferably used in view of ease of designing the polymer, ease of adjusting the adhesive force, and ensuring dispersibility of the conductive particles. The above-described adhesive polymers may be used singly, or a combination of two or more adhesive polymers may be used. In the following description, a case where the adhesive polymer is composed of an acrylic polymer or contains an acrylic polymer will be described. 
     The content (lower limit value) of the adhesive resin  711 , with respect to the total mass (100 mass %) of the adhesive layers  71 A and  71 B, is preferably 20 mass % or more, more preferably 25 mass % or more, and even more preferably 30 mass % or more. The content (upper limit value) of the adhesive resin  711 , based on the total mass (100 mass %) of the adhesive layers  71 A and  71 B, is preferably 60 mass % or less, and more preferably 55 mass % or less. 
     When the adhesive resin  711  is formed containing an acrylic polymer, the content (lower limit value) of the acrylic polymer, with respect to the total mass (100 mass %) of the adhesive resin  711 , is preferably 50 mass % or more, and more preferably 60 mass % or more. The content (upper limit value) of the acrylic polymer, with respect to the total mass (100 mass %) of the resin component, is preferably 100 mass % or less, and more preferably 90 mass % or less. 
     The acrylic polymer is not particularly limited, but is preferably an acrylic polymer composed of, for example, a (meth)acrylic acid alkyl ester having a 1-20 carbon number linear or branched alkyl group (Hereinafter referred to simply as (meth)acrylic acid alkyl ester) and a polar group-containing monomer, as monomer components. In this specification, the term “(meth)acrylic” refers to “acrylic”, “methacrylic”, or both. 
     The weight average molecular weight (Mw) of the acrylic polymer is preferably 300,000-1,000,000, and more preferably 400,000-800,000, in view of being able to exhibit more of the effect of the adhesive resin  711 . The weight-average molecular weight (Mw) can be controlled by the type and the amount of the polymerization initiator and the chain transfer agent, the temperature and the time of the polymerization, the monomer concentration, the monomer dropping rate, or the like. The weight-average molecular weight can be measured by, for example, Gel Permeation Chromatography (GPC). 
     [Conductive Particles] 
     As shown in  FIG.  7   , the conductive fine particles  712  are contained in the adhesive resin  711  in a dispersed state. 
     As the conductive fine particles  712 , particles having conductivity such as metal powder are used. The materials for forming the conductive particles include, for example, metals such as nickel, iron, chromium, cobalt, aluminum, antimony, molybdenum, copper, silver, platinum, or gold, alloys or oxides thereof, or particles (powder) made of a conductive material such as a carbon material, e.g., carbon black; coated particles in which surfaces of particles, such as polymer beads, glass and ceramics, are coated with a conductive material; or the like. The coated particles also include particles in which surfaces of particles made of a conductive material are coated with another type of conductive material. Among these particles, metals and coated particles are preferable, and nickel and silver are preferably used as the metals. 
     The shape of the conductive fine particles  712  may be spherical, spiky (chestnut), flaky (thin piece), filamentous, or the like, and may be selected as appropriate. When the conductive fine particles  712  are spherical, the conductive fine particles  712  are easily dispersed uniformly in the adhesive resin  711 , so that the adhesive force is easily secured and the conductive path by the conductive fine particles  712  in the adhesive layer  71  is easily formed. Therefore, the shape of the conductive fine particles  712  is preferably spherical. 
     The aspect ratio of the conductive fine particles  712  is preferably 1.0-1.5, and more preferably 1.0-1.1. The aspect ratio of the conductive fine particles  712  can be measured by, for example, a scanning electron microscope (SEM). 
     The particle diameter d 50  of the conductive fine particles  712  is preferably smaller than the thickness of the adhesive layers  71 A and  71 B. That is, the relation “the thickness of the adhesive layers  71 A and  71 B&gt;d 50 ” is preferably satisfied. d 50  is a 50% cumulative value (median diameter) in the particle size distribution. d 50  is measured by, for example, a laser diffraction/scattering method. When two or more kinds of conductive fine particles  712  are contained in the adhesive layers  71 A and  71 B, d 50  is calculated from the distribution obtained by mixing all kinds of conductive fine particles  712 . 
     The above relationship of d 50  allows the adhesive layers  71 A and  71 B to have higher conductivity and more excellent adhesion. When d 50  is greater than or equal to the thickness of the adhesive layer  71 , more than half of the conductive fine particles  712  are larger than the thickness of the adhesive layers  71 A and  71 B, and protrusions are formed on the surfaces of the adhesive layers  71 A and  71 B. Therefore, the contact area between the adhesive layers  71 A and  71 B and the adherend may be reduced, resulting in a decrease in adhesiveness, and the appearance may be poor. The specific range of d 50  is preferably 2 μm-20 μm, more preferably 3 μm-15 μm, and even more preferably 4 μm-10 μm. 
     The upper limit value of the content of the conductive fine particles  712 , with respect to the total mass (100 mass %) of the adhesive layers  71 A and  71 B, is preferably 70 mass % or less, more preferably 65 mass % or less, and even more preferably 60 mass % or less. The lower limit value of the content of the conductive fine particles  712  is preferably 15 mass % or more, more preferably 20 mass % or more, and even more preferably 25 mass % or more. When the content of the conductive fine particles  712  is within the above preferred range, the conductivity of the adhesive layers  71 A and  71 B can be ensured without lowering the adhesive strength of the adhesive layers  71 A and  71 B. 
     The adhesive layers  71 A and  71 B may include conductive fibers  713  as conductive fillers, as shown in  FIG.  8   . 
     The conductive fiber  713  may be any fiber having conductivity, and a publicly known fiber may be used. As the conductive fibers  713 , metal fibers such as gold, silver, platinum, copper, nickel, tin, zinc, palladium, indium tin oxide, or copper sulfide; carbon fibers such as carbon nanotubes; fibers composed of conductive polymers; fibers composed of polymers in which fibrous or granular conductive fillers are dispersed; or conductive coated fibers in which a surface of a fiber base material is coated with a conductive material, can be used. As the fiber base material, publicly known fibers can be used regardless of presence or absence of conductivity, for example, synthetic fibers such as polyester fibers, nylon fibers, acrylic fibers, polyethylene fibers, polypropylene fibers, vinyl chloride fibers, aramid fibers, polysulfone fibers, polyether fibers, or polyurethane fibers; natural fibers such as cotton, hemp, or silk; semi-synthetic fibers such as acetate; or regenerated fibers such as rayon or cupra, can be used. The above-described fibers may be used singly, or a combination of two or more fibers may be used. Examples of the conductive material for coating the surface of the fiber base material include a metal, and a conductive polymer. As the metal, a metal similar to the metal used for the metal fiber can be used. Among them, metal is preferable from the viewpoint of conductivity, durability, flexibility, and the like. Examples of the method for coating the metal include vapor deposition, sputtering, electroplating, electroless plating, and the like. 
     The fiber diameter of the conductive fiber  713  is preferably less than 1.1 μm, more preferably 300 nm-1.0 μm, even more preferably 400 nm-700 nm. If the content of the conductive fibers  713  is within the above preferred range, the conductivity of the adhesive layer  71  can be ensured without lowering the adhesive force of the adhesive layers  71 A and  71 B. 
     The fiber length of the conductive fiber  713  is not particularly limited, and can be appropriately selected according to the type, thickness, volume, and the like of the adhesive layers  71 A and  71 B. The fiber diameter and the fiber length of the conductive fiber  713  can be measured by a scanning electron microscope. 
     The adhesive layers  71 A and  71 B may include a conductive substrate as shown in  FIG.  9   . A conductive double-sided adhesive tape provided with a conductive substrate in the adhesive layers  71 A and  71 B is referred to as a so-called conductive double-sided adhesive tape with a substrate. That is, the conductive adhesive tape  57  may be constituted by providing the adhesive layers  71  on both surfaces of the conductive substrate  714 . 
     Further, the adhesive layer  71  may include other layers such as an intermediate layer, or an undercoat layer, in addition to the conductive fibers and the conductive substrate, to the extent that the purpose of the conductive adhesive tape  57  is not impaired. 
     When the battery  54  is attached to the biosensor  1 , the first conductive adhesive tape  57 A and the second conductive adhesive tape  57 B are attached to the entire positive electrode pattern  55  and the entire negative electrode pattern  56 , respectively. Then, the positive terminal and the negative terminal of the battery  54  are respectively stuck to the positive electrode pattern  55  and the negative electrode pattern  56  via the first conductive adhesive tape  57 A and the second conductive adhesive tape  57 B, so that the battery  54  is mounted on the battery mounting portion  522 . The sensor body  52  shown in  FIG.  4    shows a state in which the battery  54  is sandwiched between the positive electrode pattern  55  and the negative electrode pattern  56  with the constriction portion  522   c  being bent, so that the battery is mounted on the battery mounting portion  522 . 
     As shown in  FIG.  3   , for the biosensor  1 , in order to protect the biological adhesive layer  10  and the electrode  40  on the sticking surface side (−Z-axis direction), a release paper  60  is preferably stuck until the biosensor  1  is affixed to the living body. The adhesive force of the sticking adhesive layer  12  of the biological adhesive layer  10  can be maintained by peeling the release paper  60  from the biological adhesive layer  10  and the electrode  40  when the biosensor  1  is used. 
       FIG.  10    is an explanatory diagram showing a state in which the biosensor  1  of  FIG.  1    is affixed to a chest of a living body P. For example, the biosensor  1  is affixed to a skin of a subject P, the longitudinal direction (Y-axis direction) aligned with the sternum of the subject P, with one electrode  40  on the upper side and the other electrode  40  on the lower side. The biosensor  1  acquires a biological signal such as an electrocardiogram signal from the subject P by means of the electrode  40  in a state where the electrode  40  is pressed to the skin of the subject P by sticking the sticking adhesive layer  12  in  FIG.  3    to the skin of the subject P. The biosensor  1  stores the acquired biological signal data in a nonvolatile memory such as a flash memory mounted on the component mounting portion  521 . 
     As described above, the biosensor  1  includes the positive electrode pattern  55  and the negative electrode pattern  56 , and in the conductive adhesive tape  57 , when an iron ball having a weight of 33 g is dropped vertically from a height of 30 cm to apply a load to the surface, the fluctuation width of the resistance value is set to be 1.60Ω or less in absolute value. Thus, by suppressing the fluctuation of the resistance value when a load is applied to the surface of the conductive adhesive tape  57 , a stable conduction can be secured. Therefore, the biosensor  1  can suppress a resistance fluctuation of the conductive adhesive tape  57  and an increase in the resistance even when the biosensor  1  is pressed against the skin  2  of the subject or the subject moves during the use of the biosensor  1 , thereby suppressing a decrease in the supply voltage from the battery  54  to the component mounting portion  521 . Therefore, the biosensor  1  can stably supply a voltage from the battery  54  to the component mounting portion  521  by suppressing the decrease in the supply voltage from the battery  54  to the component mounting portion  521 . 
     Therefore, the biosensor  1  can prevent the operation of the component mounting portion  521  from stopping even when the biosensor  1  is pressed against the skin of the subject or the subject moves during the use of the biosensor  1 , so that biological information can be stably measured from the skin  2 . 
     The biosensor  1  may include a positive electrode pattern  55  and a negative electrode pattern  56  as electrode portions in the sensor portion  50 , and a first conductive adhesive tape  57 A and a second conductive adhesive tape  57 B as the conductive adhesive tape  57 . When the positive terminal and the negative terminal of the battery  54  are provided in mutually opposite directions, the first conductive adhesive tape  57 A can be disposed between the positive terminal of the battery  54  and the positive electrode pattern  55 , and the second conductive adhesive tape  57 B can be disposed between the negative terminal of the battery  54  and the negative electrode pattern  56 , in the biosensor  1 . Thus, the biosensor  1  can form a laminate in which the positive electrode pattern  55 , the first conductive adhesive tape  57 A, the battery  54 , the second conductive adhesive tape  57 B, and the negative electrode pattern  56  are laminated in this order between the pad portion  522   a  and the pad portion  522   b  of the sensor portion  50 . Therefore, when the battery  54  is a battery in which the positive terminal and the negative terminal are arranged in opposite directions to each other, such as a button type battery, the biosensor  1  can compactly store the sensor portion  50  in the biosensor  1 , and can suppress a resistance fluctuation of the conductive adhesive tape  57  and an increase in the resistance of the conductive adhesive tape  57  even when a load is applied to the inside of the casing due to pressure against the skin of the subject or body movement during use. 
     Further, in the biosensor  1 , the conductive adhesive tape  57  may be provided with an adhesive layer  71  containing an adhesive resin  711  and conductive fine particles  712 . Since the rigidity of the conductive adhesive tape  57  depends mainly on the adhesive layer  71 , as the conductive adhesive tape  57  is constituted with the adhesive layer  71 , the bending load per unit bending deflection of the conductive adhesive tape  57  can be easily reduced. Therefore, the biosensor  1  can more easily suppress a fluctuation of the resistance of the conductive adhesive tape  57  even when a load is applied to the inside of the casing due to pressure against the skin of the subject or body movement during use. 
     Further, in the biosensor  1 , the conductive adhesive tape  57  can be constituted without including a substrate in the adhesive resin  711 . Since the flexibility of the adhesive resin  711  can be easily increased, the rigidity of the conductive adhesive tape  57  can be reduced. Therefore, when a load is applied to the surface of the conductive adhesive tape  57 , the conductive adhesive tape  57  is easily deformed, so that it is possible to suppress the resistance fluctuation and suppress more stably the increase in the resistance of the conductive adhesive tape  57 . 
     The conductive adhesive tape  57  can be configured containing conductive fibers in the biosensor  1 . The plurality of conductive fibers can be dispersed while the conductive fibers can easily contact each other in the adhesive resin  711 . Therefore, in the biosensor  1 , even if a load is applied to the surface of the conductive adhesive tape  57 , the conductive adhesive tape  57  easily maintains the conductivity, and the fluctuation of the resistance can be more stably suppressed. 
     In the biosensor  1 , an average fiber diameter of the conductive fibers contained in the conductive adhesive tape  57  is preferably less than 1.1 μm. Thus, the conductivity of the adhesive layer  71  can be ensured without lowering the adhesive force of the adhesive layer  71 . Therefore, the conductive adhesive tape  57  can suppress a resistance fluctuation more stably while maintaining the adhesive force and the conductivity. 
     In the biosensor  1 , a thickness of the adhesive layer  71  contained in the conductive adhesive tape  57  can be set to 20 μm-80 μm. Thus, since the conductive adhesive tape  57  can be made thin, the rigidity of the conductive adhesive tape  57  can be reduced, and it can be easily deformed. Further, the conductive adhesive tape  57  can be made thinner. Therefore, when a load is applied to the surface of the conductive adhesive tape  57 , the fluctuation of the resistance can be more easily suppressed, and the conductive adhesive tape  57  can be formed thin. 
     As described above, since the biosensor  1  can stably supply a voltage from the battery to the controller, for example, it can be suitably used for a wearable device for health care such as a biosensor. 
     In the present embodiment, the fluctuation width of the resistance value of the first conductive adhesive tape  57 A and the second conductive adhesive tape  57 B when a load under a predetermined condition is applied may be set to 1.60Ω or less in absolute value. 
     In this embodiment, the conductive adhesive tape  57  may be disposed at only one of between the positive terminal of the battery  54  and the positive electrode pattern  55  and between the negative terminal of the battery  54  and the negative electrode pattern  56 , and a conductive adhesive or the like may be used for the other of the above. 
     EXAMPLES 
     Embodiments will be described in more detail with reference to practical examples and comparative examples. However, the embodiments are not limited to these practical examples and comparative examples. 
     Example 1 
     [Preparation of Conductive Adhesive Tape] 
     A conductive adhesive tape 1 (Product name: 9707, manufactured by 3M Japan Limited) was prepared. The conductive adhesive tape 1 was an adhesive tape containing conductive fine particles (Material: Ag, Average Particle Size: 5 μm, and Filling Rate: 56 wt %) dispersed in an adhesive resin, and was a substrate-less conductive adhesive tape containing no substrate. 
     (Measurement of Thickness of Conductive Adhesive Tape) 
     The thickness of the adhesive layer was measured using a dial gauge specified in JIS B 7503. A contact surface of the dial gauge was flat and a diameter thereof was 5 mm. Using a test piece having a width of 150 mm, the thicknesses at 5 points were measured at equal intervals in the width direction with the dial gauge having a scale of 1/1000 mm, and an average value of the measured results was defined as the thickness of the adhesive layer. Since the conductive adhesive tape 1 was composed of the adhesive layer, the thickness of the adhesive layer was set to be the thickness of the conductive adhesive tape 1. 
     (Measurement of Bending Load Per Unit Bending Deflection) 
     The size of the conductive adhesive tape 1 was 2 cm in width and 15 cm in length. The conductive adhesive tape 1 was reinforced by sandwiching both sides of the conductive adhesive tape 1 with a PET film (thickness: 38 μm), and  9  test pieces, in which the conductive adhesive tape 1 was sandwiched with the PET film and laminated, were prepared. The test pieces were subjected to a three-point bending test at 23° C. using a small measuring device (EZ-Test, by Shimadzu Corporation) in accordance with a three-point bending test conforming to JIS K7171. An example of the three-point bending test is shown in  FIG.  11   . As shown in  FIG.  11   , a test piece  80  was placed on two fulcrums  81  so that a central portion of the test piece  80  was in the middle between the two fulcrums  81 , and an indenter  82  was placed on the central portion of the test piece  80 . The distance L between the fulcrums  81  was 5 cm, and the lowering (compression) speed of the indenter was 1 cm/min. The indenter was lowered to deflect the test piece  80 . When the deflection (unit: cm) was on the X-axis and the load (unit: N) was on the Y-axis, the obtained deflection (X)-load (Y) curve with the deflection up to 1 cm was regarded as an initial inclination, and the inclination of the test piece  80  was calculated. The obtained inclination was defined as a bending load per unit bending deflection. The bending load per unit bending deflection was an average value of the bending loads per unit bending deflection of the  9  test pieces  80 . 
     (Calculation of Resistance Fluctuation Value) 
     The size of the test piece of the conductive adhesive tape 1 was 1 cm in width and 1 cm in length, and an iron ball weighing 33 g was dropped from a position of 30 cm directly above the conductive adhesive tape 1, with an electric current of about 50 mA flowing through the test piece. The resistance fluctuation was calculated from the voltage fluctuation when the iron ball collided with the test piece, and the peak resistance value was measured. The resistance fluctuation value was calculated from the difference between the peak resistance value and the resistance value before the ball was dropped. When the resistance fluctuation value of the conductive adhesive tape was 1.60Ω or less, it was evaluated that the voltage stability of the conductive adhesive tape was excellent (“A” in TABLE 1), and when the resistance fluctuation value of the conductive adhesive tape exceeded 1.60Ω, it was evaluated that the voltage stability of the conductive adhesive tape was poor (“B” in TABLE 1). 
     [Preparation of Biosensor] 
     Both terminals of the battery and two electrode pads formed on the flexible substrate were bonded through the conductive adhesive tape 1, to prepare the sensor portion. A biological adhesive layer was prepared, in which an adhesive layer for sticking was formed on the side of the sticking surface of the substrate, and an adhesive layer was formed on the side opposite to the side of the sticking surface of the substrate. Further, a foamed sheet was prepared in which an adhesive layer for a casing is provided on an upper surface of a foamed sticking layer formed by laminating a foamed substrate and the adhesive layer for the substrate. After the pair of electrodes were stuck to the sticking surface side of the biological adhesive layer, the sensor portion was installed on the upper surface of the biological adhesive layer. The biosensor was prepared by installing the foamed sheet and the casing on the upper surface of the biological adhesive layer so that the sensor portion is arranged in a space formed of the foamed sheet and the casing. 
     (Evaluation of Fluctuation of Power Supply Voltage) 
     Two seconds after a current started to flow from a coin-shaped battery of the biosensor, a load (pressure: 20 N/cm 2 ) was applied to the casing located above the coin-shaped battery in the affixing direction for about 6.5 seconds, and then the pressure application was stopped. The fluctuation of the power supply voltage during this period was measured.  FIG.  12    shows the measurement results of the power supply voltage. In  FIG.  12   , the power supply voltage of the battery is indicated by a thick solid line, and the voltage applied to the component mounting portion (controller) such as the CPU where the sensor portion is installed is indicated by a thin solid line. 
     Examples 2-6 
     The same procedure as in Example 1 was performed except that the conductive adhesive tape 1 in Example 1 was changed to the following conductive adhesive tapes 2-6.  FIGS.  13  to  17    show the results of measuring the fluctuation of the power supply voltage of the biosensors prepared with the conductive adhesive tapes 2-6 in Examples 2-6.
         Conductive adhesive tape 2 (Product name CN4490, manufactured by 3M Japan Limited)   Conductive adhesive tape 3 (Product name 9725, manufactured by 3M Japan Limited)   Conductive adhesive tape 4 (Product name 9720S, manufactured by 3M Japan Limited)   Conductive adhesive tape 5 (Product name No. 7025, manufactured by Teraoka Seisakusho Co., Ltd.)   Conductive adhesive tape 6 (Product name T4420 W, manufactured by Dexerials Corporation)       

     Comparative Examples 1-3 
     The same procedure as in Example 1 was performed except that the conductive adhesive tape 1 in Example 1 was changed to the following conductive adhesive tapes 7-9.  FIGS.  18  to  20    show the results of measuring the fluctuation of the power supply voltage of the biosensors prepared with the conductive adhesive tapes 7-9 in Comparative Examples 1-3.
         Conductive adhesive tape 7 (Product name No. 792, manufactured by Teraoka Seisakusho Co., Ltd.)   Conductive adhesive tape 8 (Product name X7001, manufactured by 3M Japan Limited)   Conductive adhesive tape 9 (Product name Al-25DC, manufactured by 3M Japan Limited)       

     TABLE 1 shows types of the conductive adhesive tapes obtained in respective Examples and Comparative Examples, measurement results of resistance fluctuation values, and evaluation results of voltage stability. 
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                 Inclination 
                   
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                 by 
                   
                   
               
               
                   
                   
                   
                 Conductive fine 
                 Conductive 
                   
                   
                 bending 
                   
                   
               
               
                   
                   
                   
                 particles 
                 fiber 
                   
                 Thickness 
                 load per 
                   
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Average 
                 Average 
                 Filler 
                 of 
                 unit 
                   
                   
               
               
                   
                   
                   
                   
                 particle 
                 fiber 
                 filling 
                 conductive 
                 bending 
                 Resistance 
                   
               
               
                   
                   
                   
                   
                 diameter 
                 diameter 
                 rate 
                 adhesive 
                 deflection 
                 fluctuation 
                 Voltage 
               
               
                   
                 Type 
                 Substrate 
                 Element 
                 [μm] 
                 [μm] 
                 [wt %] 
                 tape [μm] 
                 [N/cm] 
                 value [Ω] 
                 stability 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Ex. 1 
                 Conductive 
                 Substrate 
                 Ag 
                 5 
                 — 
                 56 
                 50 
                 0.02 
                 0.06 
                 A 
               
               
                   
                 adhesive 
                 less 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 tape 1 
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Ex. 2 
                 Conductive 
                 Non- 
                 Ni 
                 6 
                 0.4 
                 26 
                 50 
                 0.02 
                 0.04 
                 A 
               
               
                   
                 adhesive 
                 woven 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 tape 2 
                 fabric 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Ex. 3 
                 Conductive 
                 Non- 
                 Ni 
                 4 
                 0.7 
                 36 
                 50 
                 0.02 
                 0.01 
                 A 
               
               
                   
                 adhesive 
                 woven 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 tape 3 
                 fabric 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Ex. 4 
                 Conductive 
                 Non- 
                 Ni 
                 4 
                 0.5 
                 28 
                 30 
                 0.01 
                 0.01 
                 A 
               
               
                   
                 adhesive 
                 woven 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 tape 4 
                 fabric 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Ex. 5 
                 Conductive 
                 Substrate 
                 Ni 
                 4 
                 — 
                 49 
                 35 
                 0.02 
                 0.05 
                 A 
               
               
                   
                 adhesive 
                 less 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 tape 5 
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Ex. 6 
                 Conductive 
                 Substrate 
                 Ni 
                 6 
                 — 
                 57 
                 35 
                 0.01 
                 0.23 
                 A 
               
               
                   
                 adhesive 
                 less 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 tape 6 
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Comp. 
                 Conductive 
                 Rolled 
                 Ni 
                 5 
                 — 
                 87 
                 90 
                 0.08 
                 3.20 
                 B 
               
               
                 ex. 1 
                 adhesive 
                 copper 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 tape 7 
                 foil 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Comp. 
                 Conductive 
                 Woven 
                 Cu 
                 3 
                 1.1 
                 40 
                 110 
                 0.04 
                 3.12 
                 B 
               
               
                 ex. 2 
                 adhesive 
                 fabric 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 tape 8 
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Comp. 
                 Conductive 
                 Aluminum 
                 Ni 
                 3 
                 — 
                 59 
                 85 
                 0.04 
                 1.68 
                 B 
               
               
                 ex. 3 
                 adhesive 
                 foil 
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 tape 9 
               
               
                   
               
            
           
         
       
     
     In Examples 1-6, as shown in TABLE 1, the resistance fluctuation value of the conductive adhesive tape was 0.23Ω or less, and as shown in  FIGS.  12  to  17   , the power supply voltage was within the range of 2.7 V-2.9 V, the voltage applied to the controller was about 2.1 V, and the voltage stability was excellent. On the other hand, in Comparative Examples 1-3, as shown in TABLE 1, the resistance fluctuation value of the conductive adhesive tape was about 1.7Ω or more, and as shown in  FIGS.  18  to  20   , the power supply voltage fluctuated within the range of 2.1 V-2.8 V, the voltage applied to the controller fluctuated within the range of 2.1 V-2.5 V, and the voltage stability was poor. 
     Therefore, in the conductive adhesive tapes of Examples 1-6, different from the conductive adhesive tapes of Comparative Examples 1-3, fluctuation in resistance can be suppressed by setting the bending load per unit bending deflection to 0.02 N/cm or less. Therefore, in the biosensor according to the present embodiment, when the predetermined conductive adhesive tape is used to connect the battery (cell) and the substrate, an increase in the resistance value can be suppressed, so that the contact impedance of the biosensor with the living body can be maintained low, and the electric signal obtained from the living body can be detected with high sensitivity and stability. Therefore, the biosensor can be effectively used to stably measure an electrocardiogram for a long period of time (for example, 24 hours) continuously while being in close contact with a skin of a subject. 
     As described above, the embodiments have been described, but the above-described embodiments are presented as examples, and the present invention is not limited to the above-described embodiments. The above-described embodiments can be implemented in various other embodiments, and various combinations, omissions, substitutions, changes, and the like can be made without departing from the scope of the invention. These embodiments and variations thereof are included in the scope and the outline of the invention, and are also included in the scope of the invention and the equivalent scope thereof recited in claims. 
     The present application claims priority under Japanese Patent Application No. 2020-059657, filed Mar. 30, 2020 with the Japan Patent Office, and the entire contents of Japanese Patent Application No. 2020-059657 are incorporated herein by reference. 
     REFERENCE SINGS LIST 
     
         
           1  Biosensor 
           2  Skin 
           10  Biological adhesive layer 
           11  Substrate 
           12  Sticking adhesive layer 
           13  Sensor adhesive layer 
           20  Foamed sheet 
           21  Foamed sticking layer 
           211  Foamed substrate 
           212  Substrate adhesive layer 
           22  Casing adhesive layer 
           30  Casing 
           40  Electrode 
           50  Sensor portion 
           51  Flexible substrate (Resin substrate) 
           52  Sensor Body 
           521  Component mounting portion (controller) 
           522  Battery mounting portion 
           54  Battery 
           55  Positive electrode pattern (first electrode portion) 
           56  Negative electrode pattern (second electrode portion) 
           57  Conductive adhesive tape 
           57 A First conductive adhesive tape 
           57 B Second conductive adhesive tape 
           71 A,  71 B Adhesive layer 
           711  Adhesive resin 
           712  Conductive fine particles (Conductive filler) 
           713  Conductive fibers