Patent Publication Number: US-2012024742-A1

Title: Light blocking container with content viewing window and contrast background

Description:
FIELD OF THE INVENTION 
     The present invention relates to containers for housing compositions, such as compositions containing active pharmaceutical agents (APAs) and the like. 
     BACKGROUND 
     Certain drug products that contain compositions with active pharmaceutical agents, such as those in liquid or powder form, may be stored in containers clear, white or opaque containers. Desirably, the user of the drug product is able to view the contents of the interior of the container to determine amount remaining and whether there is enough of the composition to administer a dosage. Many active pharmaceutical agents (APAs) are housed in either colored glass containers, or in opaque plastic containers, which may present difficulties to the user in determining the level of APA compound contained therein. This is especially problematic when the composition containing the APA is a light or clear colored liquid, which may be difficult to see when housed in a clear container. 
     Storing APA containing compositions in light colored or clear containers may also affect photosensitive APAs, which must be kept below a particular level of light exposure in order to prevent degradation or unwanted reactions. In particular, certain APA containing compositions may experience lessened efficacy, increased degradation products or even a complete loss of efficacy, after exposure to ultraviolet rays from light. It is important for such compositions to be housed in a container that shields the APA from exposure to light. 
     It is desired to provide a container which allows a user to effectively and accurately view the contents of APA containing compositions and yet also protect photosensitive APA containing compositions, if such compositions are contained therein. 
     SUMMARY OF THE INVENTION 
     In several aspects of the invention, there is provided a container for housing a composition comprising at least one active pharmaceutical agent, the container comprising an interior for housing the composition comprising at least one active pharmaceutical agent; a container wall having an inner surface and an outer surface, wherein the inner surface is in communication with the interior; and a viewing window extending through the container wall so as to permit viewing of the interior from the outside of the container; wherein the container wall includes a colorant so as to define a background in the interior, the background defining a contrasting backdrop to the composition when viewed through the viewing window. The composition may be a light or clear liquid. The composition may include at least one active pharmaceutical agent, such as mometasone furoate, such as mometasone furoate monohydrate or mometasone furoate anhydrous, budesonide, montelukast, oxymetazoline, azelastine, fluticasone furoate, fluticasone propionate and combinations or pharmaceutically acceptable salts thereof. 
     The outer surface may include titanium and/or at least one material selected from the group consisting of high density polyethylene, polypropylene, polyester, cyclic olefin copolymer and combinations thereof. The inner surface may include a material selected from the group consisting of high density polyethylene, polypropylene, polyester, cyclic olefin copolymer and combinations thereof. The window may include a material selected from the group consisting of polypropylene, cyclic olefin copolymer and combinations thereof. A particularly useful material for the window is a cyclic olefin copolymer. 
     Other embodiments provide a container for housing a composition comprising at least one active pharmaceutical agent, the container comprising an interior region, which comprises a main body portion; and a bottom portion having a tapered interior surface; and a viewing window extending from the bottom of the main body portion to the top of the main body portion, allowing a user to view the interior region wherein the main body portion includes a colorant so as to define a background in the interior region, the background defining a contrasting backdrop to the composition when viewed through the viewing window. 
     Still other embodiments provide a drug product comprising a composition comprising at least one active pharmaceutical agent; an interior for housing the composition; a container wall having an inner surface and an outer surface, wherein the inner surface is in communication with the interior; and a viewing window extending through the container wall so as to permit viewing of the interior from the outside of the container; wherein the container wall includes a colorant so as to define a background in the interior, the background defining a contrasting backdrop to the composition when viewed through the viewing window. The composition may be a light or clear liquid and it may include at least one photosensitive active pharmaceutical agent, such as mometasone furoate, such as mometasone furoate monohydrate or mometasone furoate anhydrous, budesonide, montelukast, oxymetazoline, azelastine, fluticasone furoate, fluticasone propionate and combinations or pharmaceutically acceptable salts thereof. The at least one photosensitive active pharmaceutical agent may be mometasone furoate, such as mometasone furoate monohydrate, montelukast, oxymetazoline, azelastine, fluticasone furoate, fluticasone propionate and combinations or pharmaceutically acceptable salts thereof. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  is one embodiment of a container formed in accordance with the subject invention. 
         FIG. 2  is a cross-sectional view of a container of  FIG. 1 . 
         FIG. 3  is a cross-sectional view of a container formed in accordance with a second embodiment of the subject invention. 
         FIG. 4  is a cross-sectional view of a container with a viewing window formed in accordance with a second embodiment of the subject invention. 
         FIG. 5  is a side view of a container formed in accordance with another embodiment of the subject invention. 
         FIG. 6  is a cross-sectional view of a container of  FIG. 5 . 
     
    
    
     DETAILED DESCRIPTION 
     With reference to the figures, several embodiments of the present invention are directed to a container, which may be used to house liquids, including chemical compounds, and in particular APA-containing compositions. Any APA-containing composition may be housed in the container, and in particular, the APA-containing compositions may include APAs in liquid form. Further, the APA-containing compositions may include light or dark colored compounds, or substantially transparent compounds. The APA-containing composition may be a photosensitive compound. As used herein, the term “photosensitive” may include any composition that reacts or degrades in the presence of light, and in particular may include compounds that react in the presence of ultraviolet rays. The term “photosensitive” is not limited to compounds that become completely ineffective in the presence of light, and may include compounds that only slightly react and/or lose effectiveness after exposure to light. 
     The composition may be a light or clear liquid and it may include at least one active pharmaceutical agent, such as mometasone furoate, such as mometasone furoate monohydrate or mometasone furoate anhydrous, budesonide, montelukast, oxymetazoline, azelastine, fluticasone furoate, fluticasone propionate and combinations or pharmaceutically acceptable salts thereof. Photosensitive compounds may be suitable with various embodiments of the present invention, including, but not limited to, mometasone furoate monohydrate, which is sold under the trademark NASONEX® and is sold by Schering Corporation of Kenilworth, N.J. Another example of a photosensitive compound is oxymetazoline, which is sold under the trademark AFRIN® by Schering Corporation of Kenilworth, N.J. Another example of a photosensitive compound is fluticasone furoate, which is sold under the trademark VERAMYST® by GlaxoSmithKline. 
     The container described herein may be used to simply store the APA-containing compositions, or it may be used in conjunction with a delivery system. Such delivery systems include droppers, sprayers, injectors, and the like. The container described herein is particularly well-suited to be used in conjunction with a nasal dispensing device, however it will be understood that the container may be any type or shape of container, including but not limited to nasal dispensing devices. Nasal dispensers of this type are well known in the art. Examples of such dispensers are shown, for example, in U.S. Pat. Nos. 4,274,560; 4,944,429; and 5,433,343; the entire disclosures of which are incorporated herein by reference. 
     With reference to  FIG. 1 , there is provided a container  10 , designed to house a APA-containing composition therein. The APA-containing composition may be colored or it may be clear. In several embodiments, the APA-containing composition is a light-colored or substantially clear liquid composition. The container  10  may be any shape, including cylindrical, box-shaped, irregular, or any other desired shape. The container  10  includes a container wall  20 , which forms the region into which the composition may be housed. The container wall  20  may be made of any desired materials, including glass or polymeric materials. Suitable materials for the container wall  20  include high density polyethylene (HDPE), polypropylene, polyester (such as PET, PETg), COC, and other similar materials In general, it is desirable to use a material that provides a good vapor barrier, while maintaining acceptable clarity levels and is not brittle. The container wall  20  may be made of a polymeric material such as HDPE. 
     The container  10  includes a top portion  40  and a bottom portion  50 . The container wall  20  and the bottom portion  50  may be formed as separate pieces or may be formed as one piece. It is desired that the container  10  be fluid-tight to ensure safety and efficacy of the APA composition contained therein. The container wall  20  desirably provides a color to its interior, and more desirably is opaque. The container wall  20  may include one or more colorants or opacifiers to provide the colored or opaque look of the interior of the container  10 . The interior of the container wall  20  may be a color that is contrasting to the color of the APA-containing composition contained therein. By the term “contrasting” is it understood that the interior of the container wall  20  is any color that is sufficiently different than the color of the APA-containing compound. For example, the APA-containing composition may be light or white in color, and the interior of the container wall  20  may be dark colored. Alternatively, the APA-containing compound may be dark colored, and the interior of the container wall  20  may be light or white in color. As used herein, the term “dark colored” does not necessarily refer to a black or similar color. The term “dark colored” refers to a color that is darker than the color of the APA composition or the interior of the container wall  20 . For slightly colored APA compositions, the interior of the container  10  may be any darker color, for example, a reddish or brown color as desired, and vice versa. Regardless of whether the APA-containing compound is light or dark in color, the interior of the container wall  20  and the APA composition should form a contrast in colors. 
     The container wall  20  includes at least one viewing window  30 , which extends from approximately the bottom region  50  to approximately the top region  40 . The viewing window  30  is substantially transparent, and extends through the entire thickness of the container wall  20  so as to permit viewing of the contents of the container  10  from the outside. The viewing window  30  may have a sufficient length to allow the top surface of the APA-containing composition housed in the interior  60  of the container  10  to be viewed. The container wall  20  and the viewing window  30  may be made of the same materials or they may be made of different materials. For example, the viewing window  30  may be made from monolayer or multi-layered cyclic olefin copolymer (COC), HDPE, COC, polypropylene, or combinations thereof. In one embodiment, the viewing window  30  is a multi-layered configuration, which includes more than one layer of material. In other embodiments, the viewing window may be made from COC with an over-molded PET layer. 
     The container wall  20  and the viewing window  30  may be co-molded together or may be attached together as two separate pieces. In one particular embodiment, the container wall  20  may include an outer casing made from three layers of HDPE and a viewing window  30  made from COC. In this embodiment, the materials used may be bonded together naturally. In another embodiment, the container wall  20  may be covered by an opaque label, the label having an open portion forming the viewing window  30 . In other embodiments, the container wall  20  may include a plurality of layers of HDPE with a clarified polypropylene stripe forming the viewing window  30 . 
     As may be seen in  FIG. 2 , the container  10  includes a container wall  20  having an interior surface  25  and an exterior surface  26 . The container  10  includes an interior region  60 , which houses the APA composition. The container  10  further includes a viewing window  30 , which is integrally formed with the container wall  20 , which may extend the entire thickness of the container wall  20  (i.e., from the interior surface  25  to the exterior surface  26 ). When the interior surface  25  of the container wall  20  is opaque, the user may still view the interior  60  of the container  10  through the viewing window  30 . 
     In such embodiments incorporating a viewing window  30 , the interior surface  25  of the container wall  20  may be a contrasting colored and/or opaque wall, which blocks a substantial amount of light from entering the interior  60  of the container  10 . As explained above, the interior surface  25  of the container wall  20  and the APA composition housed in the interior  60  should form a contrast in colors. The interior surface  25  of the container wall  20  may include one or more colorants or opacifiers, to create the contrasting or opaque interior surface  25  of the container wall  20 . In addition, the container wall  20  may include one or more UV protectant materials to further protect the APA containing composition contained therein. If desired, exterior surface  26  of the container wall  20  may include indicia or other markings identifying the materials contained therein. 
     The incorporation of a contrasting colored and/or opaque interior surface  25  creates a shadowing effect into the interior  60  of the container  10 , which increases the visibility of the APA compositions when viewed through the viewing window  30 . This allows the user to more clearly see the APA composition housed in the interior  60  of the container  10 , and more accurately determine whether there is enough of the composition to administer a dosage, or whether more should be obtained. The viewing window  30  may have a width that is substantially less than the overall circumference of the container wall  20 . In particular, the viewing window  30  should have a width that is less than 5% of the circumference of the container wall  20 . 
     In embodiments where the APA-containing composition housed within the container  10  is photosensitive, it has been found that as long as the viewing window  30  is of a small dimension and thickness with respect to the container  10 , there will not be an excessive level of light that enters the container  10 . The overall dimensions (width, height, thickness) of the viewing window  30  along with the inherent materials thereof affect the ability of the viewing window  30  to transmit light therethrough. A low level of light exposure to photosensitive compositions may not significantly or harmfully reduce the effectiveness of such photosensitive compositions. 
     The interior surface  25  of the container wall  20  and the viewing window  30  may come into contact with the APA-containing composition in the container  10 . As such, it is desired that these components be made from a material that is compatible with the APA-containing composition, and in particular should be void of any contaminants that may harm the APA composition. If desired, the container  10  may include one or more liners covering the interior surface  25  of the container wall  20  and/or the viewing window  30 . 
     With reference to  FIG. 3 , one embodiment of the container is depicted, which includes a multi-layered wall arrangement. This multi-wall arrangement may be useful, for example, when the colorant or opacifier used has potential to contaminate or otherwise harm the APA composition contained therein. In this embodiment, there is provided a container  110 , having multiple layers to allow for enhanced viewing of the APA compound and simultaneously protect the contents from contamination. The container  110  may have at least two layers, or three layers. The container  110  includes a first layer  112 , a second layer  114 , and optionally a third layer  116 . More layers may be incorporated if desired. The first layer  112  is located closest to the interior  118  of the container  110 , while the second layer  114  is disposed at a location further away from the interior  118  of the container  110 . The container  110  may be any shape, including cylindrical, box-shaped, irregular, or any other desired shape. The container  110  includes an interior region  118 , which is configured to house the APA-containing composition. The interior  118  (and the APA-containing composition housed therein) may be in contiguous contact with an inner surface  111  of the first layer  112 . Thus, the inner surface  111  of the first layer  112  should be made of a material that is inert to the APA-containing composition. 
     In one embodiment, the first layer  112  is sufficiently transparent to permit viewing therethrough, and is made from inert material that will not contaminate the APA-containing composition. As with the embodiment described above, the first layer  112  may be made of plastic, glass, or any other desired material. Suitable materials for the first layer  112  include HDPE, COC, polypropylene, PET, and combinations thereof. Since the first layer  112  is in contact with the APA-containing composition, it preferably does not include any material which may potentially contaminate the APA-containing composition housed therein. The second layer  114  may contain a light-protecting element, and may be made of plastic or other material. As with the embodiment described above, the second layer  114  may be made of plastic, glass, or any other desired material. Suitable materials for the second layer  114  include HDPE, COC, polypropylene, PET, and combinations thereof. The second layer  114  may include a light-protecting material, such as colorants or UV-protectant material. In several embodiments, the second layer  114  is a contrasting-colored layer and/or opaque layer, which substantially restricts light into the interior  118  of the container. As explained above, the term “contrasting” refers to a color that is in contrast to the color of the composition housed in the interior  118  of the container  110 . The second layer  114  includes an inner surface  115  and an outer surface  117 . The inner surface  115  of the second layer  114  is in contact with the outer surface  113  of the first layer  112 . 
     The container may be a mono-layer and may be dark colored as to provide a contract for the composition contained therein. 
     Finally, if desired, the container  110  may include an optional third layer  116 . The optional third layer  116  may be made from any desired material, and in one embodiment is made from a plastic material, such as HDPE, COC, polypropylene, PET, and combinations thereof. The optional third layer  116  includes an inner surface  119  and an outer surface  121 . The inner surface  119  of the third layer  116  is in contact with the outer surface  117  of the second layer  114 . The outer surface  121  of the third layer  116  is exposed to the outside of the container  110 . While the third layer  116  is most desirably transparent, the third layer  116  may or may not include a light-protecting material or colorant, depending on the user&#39;s preference. Any of the three layers, including the first layer  112 , the second layer  114 , and the optional third layer  116 , may be any color or have any opacity level. In several embodiments, at least one of the layers  112 ,  114 ,  116  is sufficiently contrasting to the APA composition to be housed therein and/or opaque to form the contrasting effect described above. 
     The layers, including the first layer  112 , the second layer  114 , and the optional third layer  116 , may be formed via any desired process. In one embodiment, the layers  112 ,  114 ,  116  are made from plastic and are co-extruded in the arrangement described above. In this fashion, the first layer  112 , which is in contact with the APA-containing composition, avoids potential leach-through of the colorant material formed with the second layer  114 . In another embodiment, the various layers may be formed separately and then applied to each other. For example, in one method of formation, the first layer  112  may be formed first, and the second layer  114  then applied to the outer surface  113  of the first layer  112 . Similarly, if desired, the optional third layer  116  may then be applied to the outer surface  117  of the second layer  114 . Any method for application of the various layers may be used. For example, the second layer  114  may be applied to the outer surface  113  of the first layer  112  as a paste, or it may be applied as a sticker onto the outer surface  113  of the first layer  112 . Similarly, the third layer  116  may be applied to the outer surface  117  of the second layer  114  as a paste or as a sticker. Again, in this fashion, the first layer  112  avoids potential leach-through of the light-protecting material of the second layer  114 . 
     As depicted in  FIG. 4 , the multi-wall container  110  may include a narrow viewing window  120 , which extends through at least a portion of each of the layers  112 ,  114 ,  116  of the container  110 , and allows the user to view the interior  118  from the outside. As explained above, the viewing window  120  allows for a shadow effect, giving the user a clearer and more accurate view of the light-colored contents in the interior  118 . The viewing window  120  may either be integrally formed with the layers  112 ,  114 ,  116 , or the viewing window  120  may be a separate piece and fitted into the container  110 . The viewing window  120  may be made from any material. In one embodiment, the viewing window  120  is made from a polymeric material, such as HDPE, COC, polypropylene, PET, and combinations thereof. The inner surface  122  of the viewing window  120  may be in contact with the interior  118 , and thus may be in contact with the APA-containing composition contained therein. Thus, to avoid contamination of the APA-containing composition, the viewing window  120  should be made of an inert material, or it should be void of contaminants. 
     In a various embodiments, the viewing window  120  extends through each of the layers of the container, such that it allows the user to view the interior  118  through the outside. The viewing window  120  may be any shape or design, including linear, circular, box shaped, curved, irregular, or any other desired shape which will allow viewing through the viewing window  120 . Desirably, the viewing window  120  is located at a position close to the bottom of the container  110 , so that the user will be able to view low levels of any contents contained in the container  110 . The viewing window  120  may have sufficient length to allow the top surface of the APA-containing composition housed in the interior  118  of the container  110  to be viewed. With the ability to view the top surface of the APA-containing composition, the amount of the APA-containing composition may effectively be evaluated. Since the container  110  includes the viewing window  120 , the user may view the contents of the container  110  without having to open the container  110  and expose the APA-containing composition to potentially harmful elements outside the container  110 . 
     In such embodiments incorporating a viewing window, any of the layers, including the first layer  112 , the second layer  114 , and/or the third layer  116  may be a contrasting colored layer as described above, which blocks a substantial amount of light from entering the interior  118  of the container  110 . The second layer  114  may be a contrasting colored and/or opaque layer. The second layer  114  may be opaque, thus blocking all light from passing through it. The second layer  114  may include one or more colorants or opacifiers, to create the contrasting or opaque second layer  114 . In addition, the second layer  114  may include one or more UV protectant materials to further protect the APA containing composition contained therein. 
     As explained above, the incorporation of a contrasting colored or opaque layer in conjunction with the viewing window  120  creates a shadow into the interior  118  of the container  110 , which increases the visibility of APA-containing compositions contained therein through the clear viewing window  120 . This allows the user to more clearly see the interior  118  of the container  110 , and more accurately determine whether there is enough of the white or light-colored APA-containing composition to administer, or whether more should be obtained. 
     The container  110  may include one or more UV protectant materials applied to the surface of any of the three layers  112 ,  114 ,  116 . The use of UV protectant materials may be useful when the APA-containing composition housed in the container  110  is a photosensitive composition. The UV protectant materials may be applied to the surfaces  112 ,  114 ,  116  at any time, and may be applied in any desired form, including by spraying, extruding, dipping, coating, or other similar methods. 
     The invention described herein may further include an access opening and/or delivery system. This embodiment may be used in either the single-wall or multi-wall design described above. For description purposes only, reference will be made to the multi-wall container  110 , although it should be appreciated that the embodiments described herein may be used with the single-wall container  10  described above. The container  110  may include an access opening, providing access into the interior  118  of the inner casing  110 . The access opening is normally covered, such that the APA-containing composition cannot be removed unless the user physically manipulates the container  110  to remove the APA-containing composition. 
     In one embodiment, a dispensing (e.g., nasal dispenser) or dropping mechanism as explained above may be fixed to the container  110  so as to have access to the interior  118  via the access opening. In this configuration, there may be a nasal dispenser in communication with the interior  118  of the container  110 . The dispenser may be configured to urge doses of the APA-containing composition from the interior  118  and into the nasal cavity of the user. The dispenser and the container  110  collectively define a device for dispensing doses of liquid into a user&#39;s nasal cavity. In other embodiments, the container  110  may include a lid or other mechanism to allow the user to seal off the interior  118  (e.g., seal off the access opening) of the container  110 . 
     In some embodiments, the container  110  may be used in conjunction with a dual component system. For example, the system may include multiple casings, where the container  110  of the present invention forms the inner casing, and thus housing the APA containing composition, and having a separate outer casing surrounding the inner casing. 
     In another embodiment, a container has a tapered bottom portion to reduce the amount of APA overage. As depicted in  FIGS. 5 and 6 , there is provided a container  200 , having an interior  215 , designed for housing a APA-containing composition  240 . The APA containing composition  240  may be liquid in form, but other forms are contemplated such as powders. The container  200  includes a main body portion  210  and a base portion  230 . The main body portion  210  and the base portion  230  may be made of the same materials or may be made of different materials, which may include any material compatible with the APA containing composition  240  housed therein. The main body portion  210  and the base portion  230  may be made of polymeric materials, such as HDPE, COC, PET, polypropylene and combinations thereof. The main body portion  210  and the base portion  230  may be colored or they may be clear. In one embodiment, the main body portion  210  and the base portion  230  are a color that is in contrast to the color of the composition housed therein, and may be opaque. As with the containers described above, the container  200  may include indicia on its body indicating the contents housed therein. 
     The main body portion  210  and the base portion  230  may be formed together as a single-piece molded unit, or they may be formed as separately molded pieces and fitted together. As will be appreciated by one of skill in the art, in view of the components of each portion of the container  200 , forming the main body portion  210  and the base portion  230  as separate pieces may offer significant manufacturing advantages. The main body portion  210  and the base portion  230  may be attached together by any known means, including by ultrasonic welding, mechanical attachment, adhesives, or other desired means. When fitted together, the main body portion  210  and the base portion  230  form an integrally connected container  200 , which is fluid-tight to safely and effectively house the APA containing composition  240  housed therein. 
     The main body portion  210  includes a visible viewing window  220 , which allows the user to view the contents in the interior  215  of the container  200 . The viewing window  220  may be in the form of a vertical stripe, however other geometric configurations are contemplated, including ovals, blocks, and other desired figures. The viewing window  220  may be disposed on any side of the main body portion  210 , including the front, back, or side. There may be more than one viewing window  220  disposed on the main body portion  210  if desired. It is desired that the viewing window  220  be of a relatively thin size, to allow viewing of the contents in the container  200 , while allowing the main body portion  210  to form the majority of the container  200  body. In one embodiment, the thickness of the viewing window  220  is less than approximately 5% of the circumference of the container  200  body. The viewing window  220  may have any desired length, and in one embodiment, the viewing window begins at or near the location where the base portion  230  is joined with the main body portion  210 . The viewing window  220  may be of a sufficient length that it extends at or near the top of the main body portion  210 . In one embodiment, the container  200  body includes a label or sticker applied to the outer surface, the label being sufficiently opaque or contrasting colored and further including a viewing window  220  as part of the label. 
     In one particular embodiment, as can be seen in  FIG. 6 , the base portion  230  includes a tapered bottom  235 . The tapered bottom  235  may extend towards the interior  215  as much as desired. The tapered bottom  235  may extend approximately to the area where the base portion  230  and the main body portion  210  are joined. The APA containing composition  240  is housed in the interior  215  of the container  200 , and is further contained in the area formed by the tapered bottom  235  of the base portion  230 . 
     The tapered bottom  235  of the base portion  230  is useful in reducing the amount of overage of APA containing composition  240  that may be left in the container  200  after the user believes that the container  200  is empty. This configuration is especially useful when a delivery system (not shown) is attached to the container  200 , and is particularly useful when the delivery system includes a spray attachment. In typical spray bottle configurations, the delivery system includes a hose that extends into the container. The hose typically is unable to effectively remove the composition that rests at the very bottom of the container. With a typical configuration, the bottom is flat, which leaves a large region for excess composition to remain. In some instances, it has been found that there may be enough composition left to administer as many as 8-10 dosages remaining unused in such typical containers. 
     In contrast, with the tapered bottom  235  of the present invention, the base region  230  provides much less area in the interior  215  of the container  200 , and thus greatly reduces the amount of APA containing composition  240  remaining in the container  200  after use. In fact, it has been determined that there is typically remaining enough of the composition  240  to provide about 2-4 dosages unused in the container  200 . The invention provided herein thus reduces the wasted amount of APA containing composition  240  to about 25% of the prior art devices. In addition, the viewing window  220  may be configured to extend only to the top of the tapered bottom  235 , so the user is not aware that the small amount of composition  240  remains, and thus will not attempt to provide a dosage when the level of composition  240  is not sufficiently high to reach the delivery system. 
     The descriptions of the embodiments of the invention have been presented for purpose of illustration and description. They are not intended to be exhaustive or to limit the invention to the precise forms disclosed, and obviously many modifications and variations are possible in light of the above teaching.