Patent Publication Number: US-5294720-A

Title: 1,4-diamino-2,3-dihydroxybutanes

Description:
This is a continuation-in-part of application Ser. No. 07/531,971 filed Jun. 1, 1990, now abandoned. 
    
    
     FIELD OF THE INVENTION 
     This invention relates to 1,4-diamino 2,3-dihydroxybutanes, a process to prepare these compounds, compositions comprising such compounds and a method of treating viral infection. 
     BACKGROUND OF THE INVENTION 
     Current treatments for viral diseases usually involve administration of compounds that inhibit viral DNA synthesis. Current treatments for AIDS (Dagani, Chem. Eng. News, Nov. 23, 1987 pp. 41-49) involve administration of compounds such as 2&#39;,3&#39;-dideoxycytidine, trisodium phosphonoformate, ammonium 21-tungsto-9-antimoniate, 1-b-D-ribofuranoxyl-1,2,4-triazole-3-carboxamide, 3&#39;-azido-3&#39;-deoxythymidine, and adriamycin that inhibit viral DNA synthesis; compounds such as AL-721 and polymannoacetate which may prevent HIV from penetrating the host cell; and compounds which treat the opportunistic infections caused by the immunosupression resulting from HIV infection. None of the current AIDS treatments have proven to be totally effective in treating and/or reversing the disease. In addition, many of the compounds currently used to treat AIDS cause adverse side effects including low platelet count, renal toxicity and bone marrow cytopenia. 
     Proteases are enzymes which cleave proteins at specific peptide bonds. Many biological functions are controlled or mediated by proteases and their complementary protease inhibitors. For example, the protease renin cleaves the peptide angiotensinogen to produce the peptide angiotensin I. Angiotensin I is further cleaved by the protease angiotension converting enzyme (ACE) to form the hypotensive peptide angiotensin II. Inhibitors of renin and ACE are known to reduce high blood pressure in vivo. However, no therapeutically useful renin protease inhibitors have been developed, due to problems of oral availability and in vivo stability. The genomes of retroviruses encode a protease that is responsible for the proteolytic processing of one or more polyprotein precursors such as the pol and gag gene products. See Wellink, Arch. Virol. 98, 1 (1988). Retroviral proteases most commonly process the gag precursor into the core proteins, and also process the pol precursor into reverse transcriptase and retroviral protease. 
     The correct processing of the precursor polyproteins by the retroviral protease is necessary for the assembly of the infectious virions. It has been shown that in vitro mutagenesis that produces protease-defective virus leads to the production of immature core forms which lack infectivity. See Crawford, J. Virol. 53, 899 (1985); Katoh et al., Virology 145 280 (1985). Therefore, retroviral protease inhibition provides an attractive possible target for antiviral therapy. See Mitsuya, Nature 325 775 (1987). 
     Moore, Biochem. Biophys. Res. Commun., 159 420 (1989) discloses peptidyl inhibitors of HIV protease. Erickson, European Patent Application No. WO 89/10752 discloses derivatives of peptides which are inhibitors of HIV protease. 
     U.S. Pat. No. 4,652,552 discloses methyl ketone derivatives of tetrapeptides as inhibitors of viral proteases. U.S. Pat. No. 4,644,055 discloses halomethyl derivatives of peptides as inhibitors of viral proteases. European Patent Application No. WO 87/07836 discloses L-glutamic acid gamma-monohydroxamate as an antiviral agent. 
     The ability to inhibit a protease provides a method for blocking viral replication and therefore a treatment for diseases, and AIDS in particular, that may have fewer side effects when compared to current treatments. The topic of this patent application is 1,4-dimino-2,3-dihydroxybutanes and the development of processes for the preparation of these diols which compounds are capable of inhibiting viral protease and which compounds are believed to serve as a means of combating viral diseases such as AIDS. The diols of this invention provide significant improvements over protease inhibitors that are known in the art. A large number of compounds have been reported to be renin inhibitors, but have suffered from lack of adequate bio-availability and are thus not useful as therapeutic agents. This poor activity has been ascribed to the unusually high molecular weight of renin inhibitors, to inadequate solubility properties, and to the presence of a number of peptide bonds, which are vulnerable to cleavage by mammalian proteases. The diols described herein have a distinct advantage in this regard, in that many do not contain peptide bonds, are of low molecular weight, and can be hydrophilic yet still inhibit the viral protease enzyme. 
     Additionally, many compounds that inhibit renin do not inhibit HIV protease. The structure-activity requirements of renin inhibitors differ from those of HIV protease inhibitors. The diols of the invention are particularly useful as HIV protease inhibitors. 
     Other HIV protease inhibitors have been reported, but to date very few have shown activity against viral replication in human cells. This lack of cellular activity is probably due to the factors discussed above for renin inhibitors. Unlike other HIV protease inhibitors, diols disclosed herein show potent inhibition of viral replication in human cells. 
     An additional advantage of the diols disclosed herein is that some of them are symmetrical. The symmetrical diols may offer improved binding potency to the HIV protease enzyme relative to dissymmetric counterparts, and are more readily prepared from inexpensive starting materials. 
     The 1,2-diol unit is one of the most ubiquitous functional groups in nature, and consequently a wealth of methods leading to its synthesis have been developed. Foremost in this arsenal are the catalytic osmylation of olefins (Behrens and Sharpless, J. Org. Chem., (1985), 50, 5696), ring opening of epoxides (Wai et al., J. Am. Chem. Soc. (1989), 111, 1123), reduction or alkylation of a-hydroxy/alkoxy carbonyls (Davis et al., J. Org. Chem., (1989), 54, 2021). Common to all of these approaches is the preexistence of the central carbon-carbon bond of the diol function. Methods that lead directly to a 1,2-diol via formation of this bond are less common and include the reaction of an a-alkoxy anion (Cohen and Lin, J. Am. Chem. Soc., (1984), 106, 1130), with a carbonyl, and the reductive coupling of two carbonyls (i.e., pinacol coupling) (Pons and Santelli, Tetrahedron, (1988), 44, 4295). 
     Of all these methods, pinacol coupling is conceptually one of the simplest methods for the synthesis of 1,2-diols. Consequently, a number of methods have been developed which utilize this reaction for the preparation of these compounds. For example, McMurry et al., report the preparation of a 1,2-diol by pinacol coupling of a dialdehyde in the presence of TiCl 3  (dimethoxyethane) 2  Zn-Cu in dimethoxyethane (McMurry et al., Tetrahedron Lett., (1988), 30, 1173). In a recent review article, Pons and Santelli describe many other methods leading to 1,2-diols which rely on low valent titanium complexes (Pons and Santelli, Tetrahedron, (1988), 44, 4295). Finally, Freudenberger et al., J. Am. Chem. Soc., (1989), 111, 8014-8016 disclose a method which utilizes a vanadium (II) complex, [V 2  C 13  (THF) 6  ] 2  [ZN 2  Cl 6  ] to couple aldehydes. 
     While these methods are generally useful for the preparation of 1,2-diols, none of these teach how amino moieties can be incorporated into the diols. Furthermore, none of the methods disclosed in the prior art teach to make four stereocenters in a selective manner. 
     EP 402 646 discloses retroviral protease inhibiting compounds of the formula: A-X-B where A and B are independently substituted amino, substituted carbonyl, functionalized imino, functionalized alkyl, functionalized acyl, functionalized heterocyclic or functionalized (heterocyclic) alkyl and X is a linking group. 
     SUMMARY OF THE INVENTION 
     There is provided by this invention a compound of the formula: ##STR1## wherein: 
     R 1  through R 4  and R 7  through R 10  are independently selected from the following groups: 
     hydrogen; 
     C 1  -C 8  alkyl substituted with 0-3 R 11  ; 
     C 2  -C 8  alkenyl substituted with 0-3 R 11  ; 
     C 3  -C 8  alkynyl substituted with 0-3 R 11  ; 
     C 3  -C 8  cycloalkyl substituted with 0-3 R 11  ; 
     C 6  -C 10  bicycloalkyl substituted with 0-3 R 11  ; aryl substituted with 0-3 R 12  ; 
     a C 6  -C 14  carbocyclic residue substituted with 0-3 R 12  ; 
     a heterocyclic ring system substituted with 0-2 R 12 , composed of 5 to 10 atoms including at least one nitrogen, oxygen or sulfur atom; 
     R 2A  through R 4A  and R 7A  through R 9A  are independently selected from the following groups: 
     hydrogen; 
     C 1  -C 4  alkyl substituted with halogen or C 1  -C 2  alkoxy; 
     benzyl substituted with halogen or C 1  -C 2  alkoxy; 
     R 5  and R 6  are independently selected from the following groups: 
     hydrogen; 
     C 1  -C 6  alkoxycarbonyl; 
     C 1  -C 6  alkylcarbonyl; 
     benzoyl; 
     phenoxycarbonyl; or 
     phenylaminocarbony; wherein said alkyl residues are substituted with 0-3 R 11 , and said aryl residues are 
     substituted with 0-3 R 12  ; or any other group that, when administered to a mammalian subject, cleaves to form the original diol in which R 5  and R 6  are hydrogen; 
     R 11  is selected from one or more of the following: 
     keto, halogen, cyano, --NR 13  R 14 , --CO 2  R 13 , --OC(═O)R 13 , --OR 13 , C 2  -C 6  alkoxyalkyl, --S(O) m  R 13 , --NHC(═NH)NHR 13 , --C(═NH)NHR 13 , --C(═O)NR 13  R 14 , --NR 14  C(═O)R 13  --, NR 14  C(═O)OR 14 , --OC(═O)NR 13  R 14 , --NR 13  C(═O)NR 13  R 14 , NR 14  SO 2  NR 13  R 14 , --NR 14  SO 2  R 13 , SO 2  NR 13  R 14 , C 1  -C 4  alkyl, C 2  -C 4  alkenyl, C 3  -C 6  cycloalkyl, C 3  -C 6  cycloalkylmethyl; 
     a C 5  -C 14  carbocyclic residue substituted with 0-3 R 12  ; 
     aryl substituted with 0-3 R 12  ; 
     or a heterocyclic ring system substituted with 0-2 R 12 , composed of 5 to 10 atoms including at least one nitrogen, oxygen or sulfur atom; 
     R 12 , when a substituent on carbon, is selected from one or more of the following: 
     phenyl, benzyl, phenethyl, phenoxy, benzyloxy, halogen, hydroxy, nitro, cyano, C 1  -C 4  alkyl, C 3  -C 6  cycloalkyl, C 3  -C 6  cycloalkylmethyl, C 7  -C 10  arylalkyl, alkoxy, --NR 13  R 14 , C 2  -C 6  alkoxyalkyl, C 1  -C 4  hydroxyalkyl, methylenedioxy, ethylenedioxy, C 1  -C 4  haloalkyl, C 1  -C 4  haloalkoxy, C 1  -C 4  alkoxycarbonyl, C 1  -C 4  alkylcarbonyloxy, C 1  -C 4  alkylcarbonyl, C 1  -C 4  alkylcarbonylamino, --S(O) m  R 13 , --SO 2  NR 13  R 14 , --NHSO 2  R 14  ; 
     or R 12  may be a 3- or 4-carbon chain attached to adjacent carbons on the ring to form a fused 5- or 6-membered ring, said 5- or 6-membered ring being optionally substituted on the aliphatic carbons with halogen, C 1  -C 4  alkyl, C 1  -C 4  alkoxy, hydroxy, or NR 13  R 14  ; or, when R 12  is attached to a saturated carbon atom it may be carbonyl or thiocarbonyl; 
     and R 12 , when a substituent on nitrogen, is selected from one or more of the following: 
     phenyl, benzyl, phenethyl, hydroxy, C 1  -C 4  hydroxyalkyl, C 1  -C 4  alkoxy, , C 1  -C 4  alkyl, C 3  -C 6  cycloalkyl, C 3  -C 6  cycloalkylmethyl, --NR 13  R 14 , C 2  -C 6  alkoxyalkyl, C 1  -C 4  haloalkyl, C 1  -C 4  alkoxycarbonyl, C 1  -C 4  alkylcarbonyloxy, C 1  -C 4  alkylcarbonyl, 
     R 13  is H, phenyl, benzyl or C 1  -C 6  alkyl; 
     R 14  is H or C 1  -C 4  alkyl; 
     or R 13  R 14  can join to form (CH 2 ) 4 , (CH 2 ) 5 , (CH 2  CH 2  N(R 15 )CH 2  CH 2 ), or (CH 2  CH 2  OCH 2  CH 2 ); 
     R 15  is H or CH 3  ; 
     m is 0, 1 or 2; 
     n and n 1  are independently 0 or 1; 
     W and W1 are independently selected from the following: 
     --NR 16  C(═Q)NR 16  --; 
     --C(═Q)NR 16  --; 
     --C(═Q)O--; 
     --NR 16  C(═Q)O--; 
     --OC(═Q)NR 16  --; 
     --NR 16  C(═Q)--; 
     --C(═Q)--; 
     --C(═Q)CH 2  --; 
     --NR 16  SO 2  NR 16  -- 
     --NR 16  SO 2  -- 
     --SO 2  NR 16  -- 
     --SO 2  --; 
     --QCH 2  --; 
     --Q--; 
     --(CH 2 ) p  NR 16  --; 
     --CH 2  CH 2  --; 
     --CH═CH--; 
     --CH(OH)CH(OH)--; 
     --CH(OH)CH 2  --; 
     --CH 2  CH(OH)--; 
     --CH(OH)--; 
     --NH--NH--; 
     --C(═O)NH--NH--; 
     --C(Cl)═N--; 
     --C(--OR 16 )═N--; . 
     --C(--NR 16  R 17 )═N--; 
     --OP(═O)(Q 1  R 16 )O--; 
     --P(═O)(Q 1  R 16 )O--; 
     --SO 2  NHC(═O)NH--; 
     X and X 1  are independently selected from the following: 
     --C(═Q)NR 16  --; 
     --C(═Q)O--; 
     --C(═Q)--; 
     --CH 2  C(═Q)--; 
     --CH 2  C(═Q)CH 2  --; 
     --C(═Q)CH 2  --; 
     --SO 2  NR 16  -- 
     --SO 2  --; 
     --CH 2  QCH 2  --; 
     --CH 2  Q--; 
     --CH 2  NR 6  --; 
     --CH 2  CH 2  --; 
     --CH═CH--; 
     --CH(OH)CH(OH)--; 
     --CH(OH)CH 2  --; 
     --CH 2  CH(OH)--; 
     --CH(OH)--; 
     --C(═O)NH--NH--; 
     --C(--OR 16 )═N--; 
     --C(--NR 16  R 17 )═N--; 
     --C(L)═N--; 
     Y and Y 1  are independently selected from the following: 
     --C(═Q)NR 16  --; 
     --(CH 2 )PC(═Q)NR 16  --; 
     --SO 2  NR 16  --; 
     --CH 2  NR 16  --; 
     --C(L)═N--; 
     --C(--OR 16 )═N--; 
     --C(--NR 16  R 17 )═N--; 
     --NR 12  C(═O)NR 16  --; 
     --(CH 2 ) p  NR 12  C(═O)NR 16  --; 
     --OC(═O)NR 16  --; 
     --(CH 2 ) p  OC(═O)NR 16  --; 
     R 16  is H, benzyl or C 1  -C 4  alkyl; 
     R 17  is H or C 1  -C 4  alkyl; 
     p is 1 or 2; 
     Q is selected from oxygen or sulfur; 
     Q 1  is selected from oxygen, sulfur, NR 14  or a direct bond; 
     and pharmaceutically acceptable salts and prodrugs thereof. 
     There is provided a process to prepare the compound of formula I comprising contacting an aldehyde of the formula: ##STR2## with an aldehyde of the formula: ##STR3## in the presence of Caulton&#39;s reagent to form the compound of Claim 1 wherein R 5  and R 6  are H and optionally contacting one or both of the alcohols with a derivatizing agent; wherein: 
     R 1  through R 4  and R 7  through R 10  are independently selected from the following groups: 
     hydrogen; 
     C 1  -C 8  alkyl substituted with 0-3 R 11  ; 
     C 2  -C 8  alkenyl substituted with 0-3 R 11  ; 
     C 3  -C 8  alkynyl substituted with 0-3 R 11  ; 
     C 3  -C 8  cycloalkyl substituted with 0-3 R 11  ; 
     C 6  -C 10  bicycloalkyl substituted with 0-3 R 11  ; 
     aryl substituted with 0-3 R 12  ; 
     a C 6  -C 14  carbocyclic residue substituted with 0-3 R 12  ; 
     a heterocyclic ring system substituted with 0-2 R 12 , composed of 5 to 10 atoms including at least one nitrogen, oxygen or sulfur atom; 
     R 2A  through R 4A  and R 7A  through R 9A  are independently selected from the following groups: 
     hydrogen; 
     C 1  -C 4  alkyl substituted with halogen or C 1  -C 2  alkoxy; 
     benzyl substituted with halogen or C 1  -C 2  alkoxy; 
     R 5  and R 6  are independently selected from the following groups: 
     hydrogen; 
     C 1  -C 6  alkoxycarbonyl; 
     C 1  -C 6  alkylcarbonyl; 
     benzoyl; 
     phenoxycarbonyl; or 
     phenylaminocarbony; wherein said alkyl residues are substituted with 0-3 R 11 , and said aryl residues are 
     substituted with 0-3 R 12  ; or any other group that, when administered to a mammalian subject, cleaves to form the original diol in which R 5  and R 6  are hydrogen; 
     R 11  is selected from one or more of the following: 
     keto, halogen, cyano, --NR 13  R 14 , --CO 2  R 13 , --OC(═O)R 13 , --OR 13 , C 2  -C 6  alkoxyalkyl, --S(O) m  R 13 , --NHC(═NH)NHR 13 , --C(═NH)NHR 13 , --C(═O)NR 13  R 14 , --NR 14  C(═O)R 13  --, NR 14  C(═O)OR 14 , --OC(═O)NR 13  R 14 , --NR 13  C(═O)NR 13  R 14 , --NR 14  SO 2  NR 13  R 14 , --NR 14  SO 2  R 13 , --SO 2  NR 13  R 14 , C 1  -C 4  alkyl, C 2  -C 4  alkenyl, C 3  -C 6  cycloalkyl, C 3  -C 6  cycloalkylmethyl; 
     a C 5  -C 14  carbocyclic residue substituted with 0-3 R 12  ; 
     aryl substituted with 0-3 R 12  ; 
     or a heterocyclic ring system substituted with 0-2 R 12 , composed of 5 to 10 atoms including at least one nitrogen, oxygen or sulfur atom. 
     R 12 , when a substituent on carbon, is selected from one or more of the following: 
     phenyl, benzyl, phenethyl, phenoxy, benzyloxy, halogen, hydroxy, nitro, cyano, C 1  -C 4  alkyl, C 3  -C 6  cycloalkyl, C 3  -C 6  cycloalkylmethyl,C 7  -C 10  arylalkyl, alkoxy, --NR 13  R 14 , C 2  -C 6  alkoxyalkyl, C 1  -C 4  hydroxyalkyl, methylenedioxy, ethylenedioxy, C 1  -C 4  haloalkyl, C 1  -C 4  haloalkoxy, C 1  -C 4  alkoxycarbonyl, C 1  -C 4  alkylcarbonyloxy, C 1  -C 4  alkylcarbonyl, C 1  -C 4  alkylcarbonylamino, --S(O) m  R 13 , --SO 2  NR 13  R 14 , --NHSO 2  R 14  ; 
     or R 12  may be a 3- or 4- carbon chain attached to adjacent carbons on the ring to form a fused 5- or 6-membered ring, said 5- or 6- membered ring being optionally substituted on the aliphatic carbons with halogen, C 1  -C 4  alkyl, C 1  -C 4  alkoxy, hydroxy, or NR 13  R 14  ; or, when R 12  is attached to a saturated carbon atom it may be carbonyl or thiocarbonyl; 
     and R 12 , when a substituent on nitrogen, is selected from one or more of the following: 
     phenyl, benzyl, phenethyl, hydroxy, C 1  -C 4  hydroxyalkyl, C 1  -C 4  alkoxy, , C 1  -C 4  alkyl, C 3  -C 6  cycloalkyl, C 3  -C 6  cycloalkylmethyl, --NR 13  R 14 , C 2  -C 6  alkoxyalkyl, C 1  -C 4  haloalkyl, C 1  -C 4  alkoxycarbonyl, C 1  -C 4  alkylcarbonyloxy, C 1  -C 4  alkylcarbonyl, 
     R 13  is H, phenyl, benzyl or C 1  -C 6  alkyl; 
     R 14  is H or C 1  -C 4  alkyl; 
     or R 13  R 14  can join to form (CH 2 ) 4 , (CH 2 ) 5 , (CH 2  CH 2  N(R 15 )CH 2  CH 2 ), or (CH 2  CH 20  CH 2  CH 2 ); 
     R 15  is H or CH 3  ; 
     m is 0, 1 or 2; 
     n and n 1  are independently 0 or 1; 
     W and W1 are independently selected from the following: 
     --NR 16  C(═Q)NR 16  --; 
     --C(═Q)NR 16  --; 
     --C(═Q)O--; 
     --NR 16  C(═Q)O--; 
     --OC(═Q)NR 16  --; 
     --NR 16  C(═Q)--; 
     --C(═Q)--; 
     --C(═Q)CH 2  --; 
     --NR 16  SO 2  NR 16  -- 
     --NR 16  SO 2  -- 
     --SO 2  NR 16  -- 
     --SO 2  --; 
     --QCH 2  --; 
     --Q--; 
     --(CH 2 ) p  NR 16  --; 
     --CH 2  CH 2  --; 
     --CH═CH--; 
     --CH(OH)CH(OH)--; 
     --CH(OH)CH 2  --; 
     --CH 2  CH(OH)--; 
     --CH(OH)--; 
     --NH--NH--; 
     --C(═O)NH--NH--; 
     --C(Cl)═N--; 
     --C(--OR 16 )═N--; 
     --C(--NR 16  R 17 )═N--; 
     --OP(═O)(Q 1  R 16 )O--; 
     --P(═O)(Q 1  R 16 )O--; 
     --SO 2  NHC(═O)NH--; 
     X and X 1  are independently selected from the following: 
     --C(═Q)NR 16  --; 
     --C(═Q)O--; 
     --C(═Q)--; 
     --CH 2  C(═Q)--; 
     --CH 2  C(═Q)CH 2  --; 
     --C(═Q)CH 2  --; 
     --SO 2  NR 16  -- 
     --SO 2  --; 
     --CH 2  QCH 2  --; 
     --CH 2  Q--; 
     --CH 2  NR 16  --; 
     --CH 2  CH 2  --; 
     --CH═CH--; 
     --CH(OH)CH(OH)--; 
     --CH(OH)CH 2  --; 
     --CH 2  CH(OH)--; 
     --CH(OH)--; 
     --C(═O)NH--NH--; 
     --C(--OR 16 )═N--; 
     --C(--NR 16  R 16 )═N--; 
     --C(L)═N--. 
     Y and Y 1  are independently selected from the following: 
     --C(═Q)NR 16  --; 
     --(CH 2 ) p  C(═Q)NR 16  --; 
     --SO 2  NR 16  --; 
     --CH 2  NR 16  --; 
     --C(L)═N--; 
     --C(--OR 16 )═N--; 
     --C(--NR 16  R 16 )═N--; 
     --NR 12  C(═O)NR 16  --; 
     --(CH 2 ) p  NR 12  C(═O)NR 16  --; 
     --OC(═O)NR 16  --; 
     --(CH 2 ) p  OC(═O)NR 16  --; 
     R 16  is H, benzyl or C 1  -C 4  alkyl; 
     R 17  is H Or C 1  -C 4  alkyl; 
     p is 1 or 2; 
     Q is selected from oxygen or sulfur; 
     L is Cl or Br; 
     Q 1  is selected from oxygen, sulfur, NR 14  or a direct bond; 
     and pharmaceutically acceptable salts and prodrugs thereof. Suitable derivatizing agents include, but are not limited to, acyl chlorides or anhydrides, diphenyl carbonates, and isocyanates using techniques well known to those skilled in the art. 
     A process for preparing an intermediate compound of the formula: ##STR4## comprising: (a) reacting an organometallic derivative R 18  M or R 19  M in the presence of copper (I) salts and an ether-containing, aprotic solvent system with a diepoxide of the formula: ##STR5## 
     (b) reacting the product of step (a) of the formula: ##STR6## with R 22  R 23  R 24  P and C 1  -C 6  dialkyl azodicarboxylate in the presence of an azide anion and an aprotic organic solvent generally at a temperature between -20° to 100° C.; wherein: 
     R 18  and R 19  are independently C 2  -C 8  alkyl, C 3  -C 8  cycloalkyl substituted with 0-3 R 25 , a C 6  -C 10  carbocyclic aromatic residue, for example phenyl or naphthyl, substituted with 0-3 R 26  ; 
     a heterocyclic ring system substituted with 0-2 R 26 , composed of 5 to 10 atoms including at least one nitrogen, oxygen or sulfur atom; for example, pyridyl, pyrimidinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, tetrazolyl, benzofuranyl, benzothiophenyl, indolyl, indolenyl, quinolinyl, isoquinolinyl or benzimidazolyl, piperidinyl, pyrrolidinyl, pyrrolinyl, tetrahydrofuranyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, decahydroquinolinyl or octahydroisoquinolinyl; 
     R 25  is selected from one or more of the following groups: keto, halogen, R 27  R 28  N, CO 2  R 27 , OCO 2  R 27 , OR 27 , S(O) n  R 27 , NHC(═NH)NHR 27 , C(═NH)NHR 27 , C(═O)NHR 27 , or cyano; C 3  -C 8  cycloalkyl substituted with 0-3 R 25 , a C 6  -C 10  carbocyclic aromatic residue, for example phenyl or naphthyl, substituted with 0-3 R 26  ; 
     a heterocyclic ring system substituted with 0-2 R 26 , composed of 5 to 10 atoms including at least one nitrogen, oxygen or sulfur atom; for example, pyridyl, pyrimidinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, tetrazolyl, benzofuranyl, benzothiophenyl, indolyl, indolenyl, quinolinyl, isoquinolinyl or benzimidazolyl, piperidinyl, pyrrolidinyl, pyrrolinyl, tetrahydrofuranyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, decahydroquinolinyl or octahydroisoquinolinyl; 
     R 26  is selected from one or more of the following groups: phenyl, phenoxy, benzyloxy, halogen, hydroxy, nitro, cyano, C 1  -C 4  alkyl, C 1  -C 4  alkoxy, C 2  -C 6  alkoxyalkyl,methylenedioxy, ethylenedioxy, C 1  -C 4  haloalkyl, C 1  -C 4  haloalkoxy, C 1  -C 4  alkoxycarbonyl, C 1  -C 4  alkylcarbonyloxy, C 1  -C 4  alkylcarbonyl, alkylsulfonyl, SO 2  NR 27  R 28 , and R 27  SO 2  NH; 
     R 20  and R 21  are independently H, C 1  -C 8  alkyl, a C 6  -C 10  carbocyclic aromatic residue, for example phenyl or naphthyl, substituted with 0-3 R 26 , or C 1  -C 3  alkyl substituted with a C 6  -C 10  carbocyclic aromatic residue, for example phenyl or naphthyl, substituted with 0-3 R 26  ; 
     M is lithium or magnesium; 
     R 22 , R 23  and R 24  are independently phenyl or C 1  -C 6  alkyl. 
     Also provided by this invention are the intermediates of Formula III, IV, and V. 
     A process for the preparation of saturated 3-7 membered nitrogen containing heterocycles, comprising, carrying out an intramolecular Mitsunobo reaction on a precursor molecule containing a protected nitrogen atom and a hydroxyl group separated by 2-6 atoms. 
     A process for preparing an intermediate compound of the formula: ##STR7## comprising, carrying out an intermediate Mitsunobu reaction on a compound of the formula: ##STR8## wherein: Z is COOCH 2  Ph. A process for preparing a compound of formula: ##STR9## comprising: 
     (a) preparation of the required catalyst by mixing VCl 3  (THF) 3  with freshly prepared zinc-copper couple under strictly anhydrous, deoxygenated conditions in an, aprotic solvent at room temperature; and 
     (b) reacting the product of step (a) with an aldehyde of formula (1) in an aprotic solvent at -78° C. 100° C. where the ratio of zinc-copper couple: VCl 3  (THF) 3  : aldehyde is 1-3:1-3:1. 
     There are provided methods for treatment of viral infections which comprises administering to a host in need of such treatment a pharmaceutically effective antiviral amount of the compound of the following formula: ##STR10## wherein: 
     R 1  through R 4  and R 7  through R 10  are independently selected from the following groups: 
     hydrogen; 
     C 1  -C 8  alkyl substituted with 0-3 R 11  ; 
     C 2  -C 8  alkenyl substituted with 0-3 R 11  ; 
     C 3  -C 8  alkynyl substituted with 0-3 R 11  ; 
     C 3  -C 8  cycloalkyl substituted with 0-3 R 11  ; 
     C 6  -C 10  bicycloalkyl substituted with 0-3 R 11  ; 
     aryl substituted with 0-3 R 12  ; 
     a C 6  -C 14  carbocyclic residue substituted with 0-3 R 12  ; 
     a heterocyclic ring system substituted with 0-2 R 12 , composed of 5 to 10 atoms including at least one nitrogen, oxygen or sulfur atom; 
     R 2A  through R 4A  and R 7A  through R 9A  are independently selected from the following groups: hydrogen; 
     C 1  -C 4  alkyl substituted with halogen or C 1  -C 2  alkoxy; 
     benzyl substituted with halogen or C 1  -C 2  alkoxy; 
     R 5  and R 6  are independently selected from the following groups: 
     hydrogen; 
     C 1  -C 6  alkoxycarbonyl; 
     C 1  -C 6  alkylcarbonyl; 
     benzoyl; 
     phenoxycarbonyl; or 
     phenylaminocarbony; wherein said alkyl residues are substituted with 0-3 R 11 , and said aryl residues are 
     substituted with 0-3 R 12  ; or any other group that, when administered to a mammalian subject, cleaves to form the original diol in which R 5  and R 6  are hydrogen; 
     R 11  is selected from one or more of the following: 
     keto, halogen, cyano, --NR 13  R 14 , --CO 2  R 13 , --OC(═O)R 13 , --OR 13 , C 2  -C 6  alkoxyalkyl, --S(O) m  R 13 , --NHC(═NH)NHR 13 , --C(═NH)NHR 13 , --C(═O)NR 13  R 14 , --NR 14  C(═O)R 13  --, NR 14  C(═O)OR 14 , --OC(═O)NR 13  R 14 , --NR 13  C(═O)NR 13  R 14 , NR 14  SO 2  NR 13  R 14 , --NR 14  SO 2  R 13 , --SO 2  NR 13  R 14 , C 1  -C 4  alkyl, C 2  -C 4  alkenyl, C 3  -C 6  cycloalkyl, C 3  -C 6  cycloalkylmethyl; 
     a C 5  -C 14  carbocyclic residue substituted with 0-3 R 12  ; 
     aryl substituted with 0-3 R 12  ; 
     or a heterocyclic ring system substituted with 0-2 R 12 , composed of 5 to 10 atoms including at least one nitrogen, oxygen or sulfur atom; 
     R 12 , when a substituent on carbon, is selected from one or more of the following: 
     phenyl, benzyl, phenethyl, phenoxy, benzyloxy, halogen, hydroxy, nitro, cyano, C 1  -C 4  alkyl, C 3  -C 6  cycloalkyl, C 3  -C 6  cycloalkylmethyl,C 7  -C 10  arylalkyl, alkoxy, --NR 13  R 14 , C 2  -C 6  alkoxyalkyl, C 1  -C 4  hydroxyalkyl, methylenedioxy, ethylenedioxy, C 1  -C 4  haloalkyl, C 1  -C 4  haloalkoxy, C 1  -C 4  alkoxycarbonyl, C 1  -C 4  alkylcarbonyloxy, C 1  -C 4  alkylcarbonyl, C 1  -C 4  alkylcarbonylamino, --S(O) m  R 13 , --SO 2  NR 13  R 14 , --NHSO 2  R 14  ; 
     or R 12  may be a 3- or 4- carbon chain attached to adjacent carbons on the ring to form a fused 5- or 6-membered ring, said 5- or 6-membered ring being optionally substituted on the aliphatic carbons with halogen, C 1  -C 4  alkyl, C 1  -C 4  alkoxy, hydroxy, or NR 13  R 14  ; or, when R 12  is attached to a saturated carbon atom it may be carbonyl or thiocarbonyl; 
     and R 12 , when a subsistent on nitrogen, is selected from one or more of the following: 
     phenyl, benzyl, phenethyl, hydroxy, C 1  -C 4  hydroxyalkyl, C 1  -C 4  alkoxy, , C 1  -C 4  alkyl, C 3-C   6  cycloalkyl, C 3  -C 6  cycloalkylmethyl, --NR 13  R 14 , C 2  -C 6  alkoxyalkyl, C 1  -C 4  haloalkyl, C 1  -C 4  alkoxycarbonyl, C 1  -C 4  alkylcarbonyloxy, C 1  -C 4  alkylcarbonyl; 
     R 13  is H, phenyl, benzyl or C 1  -C 6  alkyl; 
     R 14  is H or C 1  -C 4  alkyl; 
     or R 13  R 14  can join to form (CH 2 ) 4 , (CH 2 ) 5 , (CH 2  CH 2  N(R 15 )CH 2  CH 2 ), or (CH 2  CH 2  OCH 2  CH 2 ); 
     R 15  is H or CH 3  ; 
     m is 0, 1 or 2; 
     n and n 1  are independently 0 or 1; 
     W and W1 are independently selected from the following: 
     --NR 16  C(═Q)NR 16  --; 
     --C(═Q)NR 16  --; 
     --C(═Q)O--; 
     --NR 16  C(═Q)O--; 
     --OC(═Q)NR 16  --; 
     --NR 16  C(═Q)--; 
     --C(═Q)--; 
     --C(═Q)CH 2  --; 
     --NR 16  SO 2  NR 16  -- 
     --NR 16  SO 2  -- 
     --SO 2  NR 16  -- 
     --SO 2  --; 
     --QCH 2  --; 
     --Q--; 
     --(CH 2 ) p  NR 16  --; 
     --CH 2  CH 2  --; 
     --CH═CH--; 
     --CH(OH)CH(OH)--; 
     --CH(OH)CH 2  --; 
     --CH 2  CH(OH)--; 
     --CH(OH)--; 
     --NH--NH--; 
     --C(═O)NH--NH--; 
     --C(Cl)═N--; 
     --C(--OR 16 )═N--; 
     --C(--NR 16  R 17 )═N--; 
     --OP(═O)(Q 1  R 16 )O--; 
     --P(═O)(Q 1  R 16 )O--; 
     --SO 2  NHC(═O)NH--; 
     X and X 1  are independently selected from the following: 
     --C(═Q)NR 16  --; 
     --C(═Q)O--; 
     --C(═Q)--; 
     --CH 2  C(═Q)--; 
     --CH 2  C(═Q)CH 2  --; 
     --C(═Q)CH 2  --; 
     --SO 2  NR 16  -- 
     --SO 2  --; 
     --CH 2  QCH 2  --; 
     --CH 2  Q--; 
     --CH 2  NR 16  --; 
     --CH 2  CH 2  --; 
     --CH═CH--; 
     --CH(OH)CH(OH)--; 
     --CH(OH)CH 2  --; 
     --CH 2  CH(OH)--; 
     --CH(OH)--; 
     --C(═O)NH--NH--; 
     --C(--OR 16 )═N--; 
     --C(--NR 16  R 17 )═N--; 
     --C(L)═N--; 
     Y and Y 1  are independently selected from the following: 
     --C(═Q)NR 16  --; 
     --(CH 2 )PC(═Q)NR 16  --; 
     --SO 2  NR 16  --; 
     --CH 2  NR 16  --; 
     --C(L)═N--; 
     --C(--OR 16 )═N--; 
     --C(--NR 16  R 17 )═N--; 
     --NR 12  C(═O)NR 16  --; 
     --(CH 2 ) p  NR 12  C(═O)NR 16  --; 
     --OC(═O)NR 16  --; 
     --(CH 2 ) p  OC(═O)NR 16  --; 
     R 16  is H, benzyl or C 1  -C 4  alkyl; 
     R 17  is H or C 1  -C 4  alkyl; 
     p is 1 or 2; 
     Q is selected from oxygen or sulfur; 
     L is Cl or Br; 
     Q 1  is selected from oxygen, sulfur, NR 14  or a direct bond; and pharmaceutically acceptable salts and prodrugs thereof. 
     PREFERRED EMBODIMENTS 
     Compounds preferred for use in the method of this invention include the following: ##STR11## 
     R 1  and R 10  are independently selected from the following: 
     hydrogen; 
     C 1  -C 6  alkyl substituted with 0-2 R 11  ; 
     C 3  -C 6  cycloalkyl substituted with 0-2 R 11  ; 
     C 6  -C 10  bicycloalkyl substituted with 0-2 R 11  ; 
     aryl substituted with 0-3 R 12  ; 
     a C 6  -C 14  carbocyclic residue substituted with 0-2 R 12  ; 
     a heterocyclic ring system substituted with 0-2 R 12 , composed of 5 to 10 atoms including at least one nitrogen, oxygen or sulfur atom; 
     R 3  and R 8  are independently selected from the following groups: 
     hydrogen; 
     C 1  -C 5  alkyl substituted with 0-2 R 11  ; 
     C 2  -C 4  alkenyl substituted with 0-2 R 11  ; 
     C 3  -C 6  cycloalkyl substituted with 0-2 R 11  ; 
     with the proviso that the total number of non-hydrogen atoms comprising R 3  is less than or equal to 6, and the total number of non-hydrogen atoms comprising R 8  is less than or equal to 6; 
     R 4  and R 7  are independently selected from the following groups: 
     hydrogen; 
     C 1  -C 4  alkyl substituted with 0-3 R 11  ; 
     C 2  -C 3  alkenyl substituted with 0-3 R 11  ; 
     R 3A , R 4A , R 7A  and R 8A  are independently selected from the following groups: 
     hydrogen; 
     C 1  -C 2  alkyl; 
     R 4  and R 6  are independently selected from the following groups: 
     hydrogen, or any other group that, when administered to a mammalian subject, cleaves to form the original diol in which R 5  and R 6  are hydrogen; 
     R 11  is selected from one or more of the following: 
     keto, halogen, cyano, --NR 13  R 14 , --CO 2  R 13 , --OC(═O)R 13 , --OR 13 , C 2  -C 6  alkoxyalkyl, --S(O) m  R 13 , --NHC(═NH)NHR 13 , --C(═NH)NHR 13 , --C(═O)NR 13  R 14 , --NR 14  C(═O)R 13  --, NR 14  C(═O)OR 14 , --OC(═O)NR 13  R 14 , NR 13  C(═O)NR 13  R 14 , --NR 14  SO 2  NR 13  R 14 , --NR 14  SO 2  R 13 , --SO 2  NR 13  R 14 , C 1  -C 4  alkyl, C 2  -C 4  alkenyl, C 3  -C 6  cycloalkyl, C 3  -C 6  cycloalkylmethyl; 
     a C 5  -C 14  carbocyclic residue substituted with 0-3 R 12  ; 
     aryl substituted with 0-3 R 12  ; 
     or a heterocyclic ring system substituted with 0-2 R 12 , composed of 5 to 10 atoms including at least one nitrogen, oxygen or sulfur atom; 
     R 12 , when a substituent on carbon, is selected from one or more of the following: 
     phenyl, benzyl, phenethyl, phenoxy, benzyloxy, halogen, hydroxy, nitro, cyano, C 1  -C 4  alkyl, C 3  -C 6  cycloalkyl, C 3  -C 6  cycloalkylmethyl,C 7  -C 10  arylalkyl, alkoxy, --NR 13  R 14 , C 2  -C 6  alkoxyalkyl, C 1  -C 4  hydroxyalkyl, methylenedioxy, ethylenedioxy, C 1  -C 4  haloalkyl, C 1  -C 4  haloalkoxy, C 1  -C 4  alkoxycarbonyl, C 1  C 4  alkylcarbonyloxy, C 1  -C 4  alkylcarbonyl, C 1  -C 4  alkylcarbonylamino, --S(O) m  R 13 , --SO 2  NR 13  R 14 , --NHSO 2  R 14  ; 
     or R 12  may be a 3- or 4-carbon chain attached to adjacent carbons on the ring to form a fused 5- or 6-membered ring, said 5- or 6-membered ring being optionally substituted on the aliphatic carbons with halogen, C 1  -C 4  alkyl, C 1  -C 4  alkoxy, hydroxy, or NR 13  R 14  ; or, when R 12  is attached to a saturated carbon atom it may be carbonyl or thiocarbonyl; and R 12 , when a substituent on nitrogen, is selected from one or more of the following: 
     benzyl, hydroxy, C 1  -C 4  alkoxy, C 1  -C 5  hydroxyalkyl, C 1  -C 4  alkyl, C 3  -C 6  cycloalkyl, C 3  -C 6  cycloalkylmethyl, C 1  -C 4  alkoxycarbonyl, C 1  -C 4  alkylcarbonyloxy, C 1  -C 4  alkylcarbonyl, 
     R 13  is H, benzyl or C 1  -C 4  alkyl; 
     R 14  is H or C 1  -C 4  alkyl; 
     or R 13  R 14  can join to form (CH 2 ) 4 , (CH 2 ) 5 , (CH 2  CH 2  N(R 15 )CH 2  CH 2 ), or (CH 2  CH 2  OCH 2  CH 2 ); 
     R 15  is H or CH 3  ; 
     m is 0, 1 or 2; 
     W and W1 are independently selected from the following: 
     --NR 16  C(═Q)NR 16  --; 
     --C(═Q)NR 16  --; 
     --OC(═Q)NR 16  --; 
     --NR 16  SO 2  NR 16  -- 
     --SO 2  NR 16  -- 
     --(CH 2 ) p  NR 16  --; 
     --P(═O)(Q 1  R 16 )O--; 
     --SO 2  NHC(═O)NH--; 
     Y and Y 1  are independently selected from the following: 
     --C(═Q)NR 16  --; 
     --NR 12  C(═O)NR 16  --; 
     --OC(═O)NR 16  --; or 
     --(CH 2 ) p  NR 13  --; 
     R 16  is H or C 1  -C 2  alkyl; 
     R 17  is H or C 1  -C 2  alkyl; 
     p is 1 or 2; 
     Q is selected from oxygen or sulfur; 
     Q 1  is selected from oxygen, sulfur, NR 14  or a direct bond; 
     and pharmaceutically acceptable salts and prodrugs thereof. 
     More preferred for greater activity and/or ease of synthesis is a compound of Formula I, wherein: ##STR12## 
     R 1  and R 10  are independently selected from the following: 
     hydrogen; 
     C 1  -C 6  alkyl substituted with 0-1 R 18  ; 
     C 2  -C 4  alkenyl substituted with 0-1 R 18  ; 
     aryl substituted with 0-1 R 19  ; 
     a heterocyclic ring system, substituted with 0-1 R 19 , selected from pyridyl, pyrimidinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, tetrazolyl, benzofuranyl, benzothiophenyl, indolyl, indolenyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, pyrrolidinyl,tetrahydrofuranyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, or decahydroisoquinolinyl; 
     wherein R 18  is chosen from the following group: 
     keto, halogen, cyano, --NR 13  R 14 , --C 02  R 13 , --OC(═O)R 13 , --OR 13 , C 2  -C 6  alkoxyalkyl, --S(O) m  R 13 , --NHC(═NH)NHR 13 , --C(═O)NR 13  R 14 , --NR 14  C(═O)R 13  --, NR 14  C(═O)OR 14 , --OC(═O)NR 13  R 14 , NR 13  C(═O)NR 13  R 14 , --NR 14  so2NR 13  R 14 , --NR 14  SO 2  R 13 , --SO 2  NR 13  R 14 , C 1  -C 4  alkyl, C 2  -C 4  alkenyl, or C 3  -C 6  cycloalkyl; 
     a C 5  -C 14  carbocyclic residue substituted with 0-3 R 19  ; 
     aryl substituted with 0-2 R 19  ; 
     or a heterocyclic ring system substituted with 0-2 R 19 , selected from selected from pyridyl, pyrimidinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, tetrazolyl, benzofuranyl, benzothiophenyl, indolyl, indolenyl, quinolinyl, isoquinolinyl, benzimidazolyl, piperidinyl, pyrrolidinyl,tetrahydrofuranyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, or decahydroisoquinolinyl; 
     wherein R 19 , when a substituent on carbon, is selected from the following: 
     halogen, hydroxy, nitro, cyano, methyl, methoxy, --NR 13  R 14 , C 1  -C 4  haloalkyl, C 1  -C 2  alkoxycarbonyl, C 1  -C 2  alkylcarbonyloxy, C 1  -C 2  alkylcarbonylamino, SO 2  NR 13  R 14 , or --NHSO 2  R 14  ; 
     and R 19 , when a substituent on nitrogen, is C 1  -C 4  alkyl; 
     R 3  and R 8  are independently selected from the following groups: 
     hydrogen; 
     C 1  -C 5  alkyl substituted with 0-3 halogen or 0-1 R 20  ; 
     C 2  -C 4  alkenyl substituted with 0-3 halogen or 0-1 R 20  ; 
     C 3  -C 6  - cycloalkyl substituted with 0-3 halogen or 0-1 R 20  ; 
     wherein R 20  is selected from the following groups: 
     keto, amino, methylamino, dimethylamino, --C(═O)NH 2 , C(═O)NMe2, C(═O)NHMe, or C 3  -C 5  cycloalkyl; 
     with the proviso that the total number of non-hydrogen atoms comprising R 3  is less than or equal to 6, and the total number of non-hydrogen atoms comprising R 8  is less than or equal to 6; 
     R 4  and R 7  are independently selected from the following groups: 
     C 1  -C 4  alkyl substituted with 0-3 halogen or 0-1 R 21 , wherein R 21  is selected from the following groups: 
     keto, halogen, cyano, --NR 13  R 14 , --CO 2  R 13 , --OC(═O)R 13 , --OR 13 , C 2  -C 4  alkoxyalkyl, --S(O) m  R 13 , --C 3  -C 6  cycloalkyl; 
     a C 5  -C 10  carbocyclic residue substituted with 0-1 R 22  ; 
     aryl substituted with 0-1 R 22  ; 
     or a heterocyclic ring system, substituted with 0-1 R 22 , selected from pyridyl, thienyl, indolyl, piperazyl, N-methylpiperazyl, or imidazolyl; 
     wherein R 22  is selected from one or more of the following groups: 
     benzyl, benzyloxy, halogen, hydroxy, nitro, C 1  -C 4  alkyl, C 1  -C 4  alkoxy, amino, methylamino, dimethylamino, haloalkyl, haloalkoxy, --C(═O) 2  R 14 , or --OC(O 2 )R 14  ; 
     R 3A , R 4A , R 7A  and R 8A  are hydrogen; 
     R 5  and R 6  are independently selected from the following groups: hydrogen, or any other group that, when administered to a mammalian subject, cleaves to form the original diol in which R 5  and R 6  are hydrogen; 
     R 13  and R 14  are independently selected from H or C 1  -C 2  alkyl; 
     m is 0, 1 or 2; 
     n and n 1  are 0; 
     W and W1 are independently selected from the following: 
     --NR 16  C(═Q)NR 16  --; 
     --C(═O)NR 16  --; 
     --OC(═O)NR 16  --; 
     --(CH 2 ) p  NR 16  --; 
     Y and Y 1  are independently selected from the following: 
     --C(═O)NR 16  --; 
     --NR 12  C(═O)NR 16  --; 
     --OC(═O)NR 16  --; or 
     --(CH 2 ) p  NR 16  --; 
     R 16  is H or methyl; 
     p is 1 or 2; 
     Q is selected from oxygen or sulfur; and pharmaceutically acceptable salts and prodrugs thereof. 
     Specific examples of compounds useful in various embodiments of the invention include compounds of the formula: 
     a) (S,R,R,S)--N-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3-dihydroxy-5-(1H-pyrrol-1-yl)-1-[(1H -pyrrol-1-yl)methyl]pentyl]-N 2  -formyl-L-valinamide 
     b) (S,R,R,S)--N-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3-dihydroxy-5-phenyl-1-(phenylmethyl)pentyl]-N 2  -[[N-[(1H -benzimidazol-2-yl)methyl]-N-methylamino]carbonyl]-L-valinamide 
     c) (S,R,R,S)-N-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3-dihydroxy-5-(4-pyridinyl)-1-(4-pyridinylmethyl)pentyl]-N 2  -formyl-L-valinamide 
     d) [S,R,R,S(2S*,3S*)]-(1,1-dimethylethyl) [2,3-dihydroxy-4-[(3-hydroxy-4-methoxy-2-(1-methylethyl)-1-oxobutyl]amino]-5-(4-pyridinyl)-1-(4-pyridinylmethyl)pentyl]carbamate 
     e) (S,R,R,S)-N-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3-dihydroxy5-(4-pyridinyl)-1-(4-pyridinylmethyl)pentyl]-N 2  -[(phenylmethoxy)carbonyl]-L-valinamide 
     f) (S,R,R,S)-N 2  -[[1(dimethylamino)cyclopropyl]carbonyl]-N-[4-[[(1,1-dimethyl-ethoxy)carbonyl]amino]-2,3-dihydroxy-5-phenyl-1-(phenylmethyl)pentyl]-N-L-valinamide 
     g) (S,R,R,S)-N-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3-dihydroxy1-(phenylmethyl)hexyl]-N 2  -(N-methyl-L-alanyl)-L-valinamide 
     h) (S,R,R,S)-(1,1-dimethylethyl) [4-[[[2-[(dimethylamino)methyl]-1H -imidazol-5-yl]carbonyl]amino]-2,3-dihydroxy-5-phenyl-1-(phenylmethyl)-pentyl]carbamate 
     i) (S,R,R,S)-N 2  -[[[2-[(dimethylamino)carbonyl]phenyl]methoxy]carbon yl]-N-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3-dihydroxy-5-phenyl-1-(phenylmethyl)pentyl]-L-valinamide 
     j) (S,R,R,S)-N,N&#39;-[2,3-dihydroxy-1,4-bis(phenylmethyl)-1,4-butanediyl]bis[N.sub.2 -(4-aminobenzoyl)-L-valinamide] 
     k) (S,R,R,S)-N 2  -[[[4-(dimethylamino)phenyl]methoxy]carbonyl]-N-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3-dihydroxy-5-phenyl-1-(phenylmethyl)pentyl]-L-valinamide 
     l) (S,R,R,S)-N 2  -[[[4-[(dimethylamino)methyl]phenyl]methoxy]carbonyl]-N-[4-[[(1,1-dimethylethoxy)carbonyl]amino]-2,3-dihydroxy-5-phenyl-1-(phenylmethyl)pentyl]-L-valinamide. 
     The compounds herein described may have asymmetric centers. All chiral, diastereomeric and racemic forms are included in the present invention. Many geometric isomers of olefins, C═N double bonds, and the like can also be present in the compounds described herein, and all such stable isomers are contemplated in the present invention. 
     When any variable (for example, R 1  through R 17 , R 2A  through R 9A , m, n, p, Q, W, X, Y, Z, etc.) occurs more than one time in any constituent or in formula (I), its definition on each occurrence is independent of its definition at every other occurrence. Also, combinations of substituents and/or variables are permissible only if such combinations result in stable compounds. 
     As used herein, &#34;alkyl&#34; is intended to include both branched and straight-chain saturated aliphatic hydrocarbon groups having the specified number of carbon atoms; &#34;alkoxy&#34; represents an alkyl group of indicated number of carbon atoms attached through an oxygen bridge; &#34;cycloalkyl&#34; is intended to include saturated ring groups, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl; and &#34;biycloalkyl&#34; is intended to include saturated bicyclic ring groups such as [3.3.0]bicyclooctane, [4.3.0] bicyclononane, [4.4.0]bicyclodecane (decalin), [2.2.2]bicyclooctane, and so forth. &#34;Alkenyl&#34; is intended to include hydrocarbon chains of either a straight or branched configuration and one or more unsaturated carbon-carbon bonds which may occur in any stable point along the chain, such as ethenyl, propenyl and the like; and &#34;alkynyl&#34; is intended to include hydrocarbon chains of either a straight or branched configuration and one or more triple carbon-carbon bonds which may occur in any stable point along the chain, such as ethynyl, propynyl and the like. &#34;Halo&#34; as used herein refers to fluoro, chloro, bromo and iodo; and &#34;counterion&#34; is used to represent a small, negatively charged species such as chloride, bromide, hydroxide, acetate, sulfate and the like. 
     As used herein, &#34;aryl&#34; or &#34;aromatic residue&#34; is intended to mean phenyl or naphthyl; &#34;carbocyclic&#34; is intended to mean any stable 5- to 7-membered monocyclic or bicyclic or 7- to 14-membered bicyclic or tricyclic carbon ring, any of which may be saturated, partially unsaturated, or aromatic. 
     As used herein, the term heterocycle is intended to mean a stable 5- to 7-membered monocyclic or bicyclic or 7- to 10-membered bicyclic heterocyclic ring which is either saturated or unsaturated, and which consists of carbon atoms and from 1 to 3 heteroatoms selected from the group consisting of N, O and S and wherein the nitrogen and sulfur heteroatoms may optionally be oxidized, and the nitrogen may optionally be quaternized, and including any bicyclic group in which any of the above-defined heterocyclic rings is fused to a benzene ring. The heterocyclic ring may be attached to its pendant group at any heteroatom or carbon atom which results in a stable structure. The heterocyclic rings described herein may be substituted on carbon or on a nitrogen atom if the resulting compound is stable. Examples of such heterocycles include, but are not limited to, pyridyl, pyrimidinyl, furanyl, thienyl, pyrrolyl, pyrazolyl, imidazolyl, tetrazolyl, benzofuranyl, benzothiophenyl, indolyl, indolenyl, quinolinyl, isoquinolinyl or benzimidazolyl, piperidinyl, 4-piperidonyl, pyrrolidinyl, 2-pyrrolidonyl, pyrrolinyl, tetrahydrofuranyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, decahydroquinolinyl or octahydroisoquinolinyl. The term &#34;substituted&#34;, as used herein, means that an one or more hydrogen on the designated atom is replaced with a selection from the indicated group, provided that the designated atom&#39;s normal valency is not exceeded, and that the substitution results in a stable compound. 
     By &#34;stable compound&#34; or &#34;stable structure&#34; is meant herein a compound that is sufficiently robust to survive: 
     isolation to a useful degree of purity from a reaction mixture, and formulation into an efficacious therapeutic agent. 
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     Synthesis 
     Compounds of formula (I) are synthesized according to the procedures discussed below. In addition to disclosing known methods for the preparation of these compounds, the present invention provides several novel processes for their synthesis. The first of these is an improved process for the preparation of compounds of formula (I) via the reductive coupling of aldehydes. A second is the stereoselective synthesis of compounds of formula (I) via a modified coupling method. A third is the stereospecific synthesis of compounds of formula (I) from mannitol. The present invention also provides novel processes for the preparation of key intermediates used in the mannitol route. 
     Reductive Coupling of Aldehydes 
     A preferred method for the preparation of compounds of formula (I) is the reductive coupling of aldehydes. This method utilizes a catalyst which contains vanadium(II); however, other low valent metals (such as titanium and samarium) and pinacol reagents (such as magnesium) can also be used with advantage. It is based on a process disclosed by Pederson et al. for the preparation of diols. Freudenberger, J. H.; Konradi, A. W.; Pedersen, S. F., J. Am. Chem. Soc. 1989, 111, 8014; and Konradi, A. W.; Pedersen, S. F., J. Org. Chem. 1990, 55, 4506. The preferred catalyst is Caulton&#39;s Reagent, [V 2  Cl 3  (THF) 6  ] 2  [ZN 2  Cl 6  ]. Preparation of this reagent has been disclosed. Bouma et al. Inorg. Chem., 23, 2715-2718. The process is shown in Scheme I. ##STR13## In the operation of this process, an aldehyde of Formula (1) and an aldehyde of Formula (2) are reacted, in a solvent, in the presence of Caulton&#39;s Reagent to give a compound of Formula (I) where R 5 , R 6  =H. Many of the compounds of formula (I) are available through the operation of the process of Pederson et al. on the corresponding aldehydes. However, the improved process for the reductive coupling of aldhydes, discussed below, is preferred over the method of Pederson et al. Improved Process for the Reductive Coupling of Aldehydes. 
     Another aspect of the present invention is an improvement of the process disclosed by Pederson et al. for the preparation of 1,4-diamino-2,3-diols. The improvement results in a process which is easier to operate than that of Pederson et al., affords reagents of higher quality and reliability than those of the method of Pederson et al., and results in a higher yield of product than that obtained by Pederson et al. 
     In practicing the improved reductive coupling process of the present invention, the catalyst is prepared by placing VCl 3  (THF) 3  in a dry, oxygen-free flask. Zinc-copper couple is then added and the two solids are stirred vigorously. An organic solvent is then added and the mixture is stirred for about 10 minutes, resulting in a deep green solution and black suspension. Next, a solution of the aldehyde in the same solvent as that used for the catalyst, is added to the catalyst over 2-3 minutes. The progress of the reaction is monitored by Thin Layer Chromatography (silica gel with 50% hexane/ethyl acetate as eluent) until it is determined that the reaction is over. The reaction mixture is then subjected to an aqueous work-up and, if necessary, the product obtained is further purified. 
     The zinc-copper couple utilized in the improved process is prepared following a known procedure, except that filtration with schlenkware was used instead of decanting solvent. L. Fieser and M. Fieser, Reagents for Organic Synthesis, Volume I, pp. 1292-1293, Wiley, New York, 1967. The use of a glovebag or drybox instead of schlenkware would be equally satisfactory. The solvents used for the preparation of this reagent are sparged with argon for about 30 minutes before use. The zinc-copper couple obtained is in the form of a free-flowing black powder with a few clumps. The zinc-copper couple prepared in this way is superior to commercially obtained or activated zinc dust. This material reduced V(III) to V(II) in dichloromethane within 10 minutes, whereas the use of commercial zinc dust or activated zinc required several hours and frequently did not provide the color change, described above, which is characteristic of complete reduction. 
     The improved reductive coupling process operates over a temperature range of from -78° to 100° C. The preferred range is from 0° to 40° C. The most preferred range is from 15° to 25° C. 
     The use of a solvent is required in practicing the improved reductive coupling process. It is anticipated that any polar, aprotic solvent will be useful. Preferred solvents are hydrocarbons, halogenated hydrocarbons and ethers. Particularly preferred are halogenated hydrocarbons such as dichloromethane and dichloroethane. 
     The improved reductive coupling process may be run over a time period of 0.1 to 24 hours. It is usually run over the time period of 0.3 to 2 hours. However, as expressed above, in practice it is most desirable to moniter the progress of the reaction by thin layer chromatography. 
     In practicing the improved reductive coupling process, it is important that the glassware and reagents be dry and free of reactive gases such as oxygen and carbon dioxide. Also, moisture, oxygen and carbon dioxide should be rigorously excluded from the reaction as it is carried out. To accomplish this, it is desirable to perform the reaction under an atmosphere of argon or nitrogen. It is desirable that the aldehyde(s) utilized in the improved reductive coupling process be freshly prepared or purified prior to use. 
     The molar ratio of each reagent is also important. The process operates where the ratio of zinc-copper couple:VCl 3  (THF) 3  :aldehyde is 1-3:1-3:1 respectively. The preferred ratio of reagents is 1-1.5:2-2.5:1. The most preferred ratio is 1-1.2:2-2.2:1. 
     The preferred reagents for the aqueous work-up step of the improved reductive coupling process is 10% disodium tartrate. If the product does not contain an acid-sensitive functionality 1N HCl may be used. 
     If necessary, the 1,4-diamino-2,3-dihydroxybutanes obtained from the improved reductive coupling process can be further purified by recrystallization or chromatography or any method commonly used in organic synthesis. 
     Stereoselective Preparation of Compounds of Formula (I) 
     Another aspect of the present invention is a method for the stereoselective preparation of compounds of formula (1) via modification of the method of Pederson et al. The reductive coupling of an aldehyde using the disclosed procedure of Pederson et al. can be expected to produce a number of stereo isomers. ##STR14## Thus, if an aldehyde, such as depicted in the equation above, with s configuration at the one stereo center is used as the substrate in this reaction, three stereo isomers can be expected to form: (1s,2s,3s,4s), (1s,2r,3r,4s), and (1s,2r,3s,4s). One aspect of the present discovery is the surprising observation that under certain reaction conditions, e.g., changing the reaction solvent, one of these isomers is selectively produced. In addition, the isomer selectivity can be controlled by changing the reaction conditions. This is useful because, even though it is believed all isomers have some level of activity in inhibiting viral protease, certain isomers are more effective, and this aspect of the present invention allows for the selective preparation of the more desirable isomer. 
     The practice of this aspect of the invention involves using a modified version of the reductive coupling method described by Pederson et al. The usual method to carry out the reductive coupling of aldehydes in the presence of Caulton&#39;s reagent is to add the reagent under inert atmosphere to a solution of the aldehyde in a nonpolar halocarbon solvent, usually dichloromethane. This procedure produces predominantly the (1s,2r,3r,4s) isomer. However, if a polar, nonprotic solvent such as dimethylformamide (DMF) is added to the aldehyde solution, before the addition of Caulton&#39;s reagent, the predominant isomer is the (1s,2s,3s,4s) isomer. Pederson et al., J. Am. Chem. Soc., 1989, 111, 8014-8016, reports the use of Caulton&#39;s reagent for reductive coupling of aldehydes. 
     Derivatization of Diols 
     Optionally, after carrying out any of the above described coupling reactions, the product diol (formula (I), R 5 , R 6  =H) can then be converted to a derivative (R 5  not equal to H, R 6  =H; R 6  not equal to H, R 5  =H; or R 5  and R 6  not equal to H) by contacting the diol product with a derivatizing agent in the presence of a suitable base The monofunctionalized compounds (e.g., R 5  =H, R 6  not equal to H) can be prepared by employing less than or equal to one molar equivalent of derivatizing agent; and the difunctionalized compounds (R 5 , R 6  not equal to H) can be prepared by employing more than two molar equivalents of derivatizing agent. Suitable derivatizing agents include, but are not limited to, acyl chlorides or anhydrides, diphenyl carbonates, and isocyanates using techniques well known to those skilled in the art. Suitable bases are organic and inorganic bases including, but not limited to, aliphatic amines, heterocyclic amines, metal carbonates and metal hydrides. 
     Preparation of Aldehydes of Formula (1) and Formula (2) 
     It is anticipated that all aldehydes will work equally well in the process shown in Scheme I and the process described above for the stereoselective synthesis of compounds of formula (1). The method works particularly well with aldehydes that contain an activating group 3,4 or 5 atoms distant from the aldehyde carbon, as discussed by Pederson et al. Aldehydes without activating groups can be coupled using higher temperatures and/or longer reaction times. Different aldehydes can be cross-coupled either by mixing two activated aldehydes and separating the statistical mixture of products, or by reacting an unactivated aldehyde with an activated aldehyde as discussed in the references of Pederson et al. Where the aldehyde of formula (1) has a structure identical to that of formula (2), the resultant compound of formula (I) is a symmetrical 1,4-diamino-2,3-dihydroxybutane. Where the aldehyde of formula (1) has a structure different from that of formula (2), the resultant compound of formula (I) is an unsymmetrical 1,4-diamino-2,3-dihydroxybutane. 
     Aldehydes of formula (1) and aldehydes of formula (2) can be obtained commercially or can be prepared in a number of ways well known to one skilled in the art of organic synthesis. Preferred methods include but are not limited to those described below for aldehydes of formula (1): 
     Method A ##STR15## 
     Compounds wherein Z is H, n is zero, and Y is --C(═Q)NR 12  --, and the other variables are as described above, can be prepared by reaction of the amine (II) with a carboxylic acid or derivative (III): ##STR16## wherein P is hydrogen or optionally an alcohol protecting group, R 10  is hydrogen or an aliphatic or substituted aromatic group, and the carboxylic acid or ester is activated to nucleophilic attack by methods well known in the art (Bodansky and Bodansky, The Practice of Peptide Chemistry, Springer-Verlag, Berlin, 1984, Chapter II, pp. 89-150), with the preferred method employing 1,1&#39;-carbonyldiimidazole as the activating agent, THF as solvent, and 0°-40° C. as temperature, and P═H. If a protecting group is necessary, the preferred group is the 2-methoxyethoxymethyl group. Greene, Protecting Groups in Organic Chemistry, Wiley, New York, 1981. Removal of the protecting group if employed, followed by oxidation (see below), provides aldehydes of formulae (V) or (VI). ##STR17## 
     Method B 
     Thioamides of structure (VII) and (VIII) can be made from the above protected hydroxyamides (IV) followed by treatment with a thionation reagent (Bodansky and Bodansky, The Practice of Peptide Chemistry, Springer-Verlag, Berlin, 1984, Chapter II, pp. 89-150), and deprotection followed by oxidation to the aldehyde. A preferred thionation reagent is Lawesson&#39;s reagent, and a preferred protecting group is the 2-methoxyethoxymethyl group (Greene, Protecting Groups in Organic Chemistry, Wiley, New York, 1981). ##STR18## 
     Method C 
     Compounds of structure (XI) and (XII) wherein Y is --SO 2  NR 12  -- can be prepared by the reaction of (II) with an activated sulfonate such as (IX), obtained as described by Bodansky and Bodansky, to produce optionally protected alcohols (X): ##STR19## wherein Act is an activating group, preferably chloride, and P is, optionally, a protecting group. Removal of the protecting group if employed, followed by oxidation (see below), provides aldehydes (XI) or (XII). ##STR20## 
     Method D 
     Compounds wherein Y is --CH 2  NR 12  -- can be prepared by the reaction of (11) with an alkylating agent such as (XIII): ##STR21## Wherein LG is a leaving group such as halogen or OSO 2  R, as is described in the art. Bodansky and Bodansky. The preferred method employs a tosylate or iodide as leaving group, and a secondary amine as the nucleophile, i.e., R 2  is not hydrogen. A preferred method for the preparation of compounds wherein R 12  is hydrogen is simply by LiAlH 4  reduction of the amides of formula (V), if hydride-sensitive functionality is not present. A final preferred method is the reaction of amines (II) with aldehydes (XXXIII), followed by reduction of the imine by catalyic hydrogenation or by borohydride reduction of the intermediate imine. ##STR22## Removal of the protecting group, if employed, followed by oxidation (see below), provides aldehydes (XV) and (XVI) ##STR23## 
     Method E 
     E} When Y is --C(Cl)═N--, --C(--OR 11 )═N--, or --C(--NR 11  R 12 )═N-- the aldehydes of Scheme I can be advantageously prepared by reaction of secondary amides or thioamides (XVII) with halogenating agents to produce imidoyl halides (X). Bodanszky and Bodansky. The synthesis of amides and thioamides (XVII) is described above (formula II, R 12  =H; see Method A). The imidoyl halides so produced can then be reacted with alcohols to produce imidates (XIX). Gautier, Miocque and Farnoux, in The Chemistry of Amidines and Imidates, Patai, Ed., Wiley, London, 1975, pp. 398-405. Alternatively, they can be reacted with amines to produce amidines (XX) as shown. Gautier, Miocque and Farnoux, in The Chemistry of Amidines and Imidates, Patai, Ed., Wiley, London, 1975, pp. 297-301. Preferred halogenating reagents include phosphorous pentachloride and phosphorous oxychloride. ##STR24## Cleavage of the protecting group and oxidation to the aldehyde as described below produces (XXI), with the indicated Y values. ##STR25## 
     Method F 
     When Y is --NR 12  C(═O)NR 12  --, the compounds of the invention can be prepared by reacting amine (II) with a derivatizing agent to form the isocyanate or carbamate, followed by reaction with a primary or secondary amine (XXIV), optionally in the presence of a base to produce the protected alcohol derivative (XXVI). Satchell and Satchell, Chem. Soc. Rev., 4, 231-250 (1975). 
     When Y is --OC(═O)NR 12 , the compounds of the invention can be prepared by reacting amine (II) with a derivatizing agent to form the isocyanate, followed by reaction with an alcohol (XXIII) in the presence of a base to produce the protected alcohol (XXV). ##STR26## Cleavage of the protecting group and oxidation to the aldehyde as described below produces (XXII), with the indicated Y values. ##STR27## 
     Method G: Oxidation of Alcohol Intermediates 
     The alcohols or protected alcohols discussed above and represented here by formula (XXVIII), ##STR28## can be readily transformed to aldehydes of formulae (1) or (2). The alcohols represented by formula (XXVIII) can be oxidized directly to the aldehydes of formulae (1) or (2) using methods that are well known in the art. March, Advanced Organic Chemistry, Wiley, New York, 1985, pp. 1057-1060. The protected alcohols represented formula (XXVIII) must be deprotected prior to oxidation; this is done using methods that are well known to those in the art. For a recent review, see Tidwell, Synthesis 857 (1990). Preferred methods of oxidation include pyridinium dichromate, pyridinium chlorochromate, pyridine/sulfur trioxide, and activated dimethyl sulfoxide. The most preferred method employs dimethylsulfoxide/oxalyl chloride, also known as Swern oxidation in dichloromethane or tetrahydrofuran/dichloromethane at -60° C., followed by treatment with a base such as triethylamine. Tidwell, Synthesis 857 (1990). 
     While the most preferred method of oxidation is gentle and specific, there are functional groups within the contemplated scope that may not survive such oxidation. Examples of these are primary alcohols, amines, indoles, sulfides, thiols. If necessary, these groups can be protected prior to oxidation of the aldehyde. Alternatively, the reductive conditions described below may be used to prepare the aldehyde when oxidative conditions cause difficulties with certain functional groups. 
     Amine (VIII) can be reacted with any of the above electrophiles, (III, IX or XIII) to form N-methoxyamide (XXIX). It is known that (XXIX) can be reduced cleanly to aldehyde by stoichiometric lithium aluminum hydride, provided that sensitive functionality is not present. Fehrentz and Castro, Synthesis 676 (1990). ##STR29## 
     Finally, there are functional groups within the contemplated scope that will survive neither lithium aluminum hydride nor oxidation. In this occasion, reduction of aminoester (XXX) with one equivalent of diisobutyl aluminum hydride at low temperature, followed by quenching at low temperature, can provide an alternative to the above conditions. Kawamura et al., Chem. Pharm. Bull 17, 1902 (1969). ##STR30## 
     Stereospecific Synthesis of Compounds of Formula (I) 
     This invention also provides a process for the steriospecific synthesis of certain compounds of formula (I) from mannitol. This process is shown in Scheme II. By steriospecific is meant this process yields one diastereomer based on the stereochemistry of the starting material. The process relies on the key intermediate 1,2,5,6-diepoxy-3,4-O-(alkylidene)hexane. This intermediate is prepared from the hexitol derivative, 2,3-O-alkylidinehexitol, which is itself derived from mannitol. The intermediate may be either the D- or L-stereoisomer; the choice of stereoisomer of the starting material determines the stereochemistry of the final product. This intermediate is prepared in two steps, by conversion of the 1,6-hydroxy groups of 2,3-O-alkylidinehexitol to suitable leaving groups, followed by reaction with a base to effect epoxide formation. The intermediate, 1,2,5,6-diepoxy-3,4-O-(alkylidene)hexane, thus prepared is then used to prepare certain compounds of Formula (I). In the next step of this process, each epoxide group of the intermediate, 1,2,5,6-diepoxy-3,4-O-(alkylidene)hexane, is reacted with an organometallic reagent to give a 2,5-dihydroxy derivative. The resulting hydroxy groups or their derivatives are then converted to amino synthons, e.g., by reaction with azide ion in the presence of compounds such as triphenylphosphine and dialkylazodicarboxylate. This procedure gives a 2,5-diazido derivative. Next, the amino synthons are converted to amino groups, e.g., by catalytic hydrogenation of azide residues. Then, the amino groups are derivatized, e.g., by reaction with an electrophile as shown in Scheme II. Finally, the alkylidine protecting group is removed to yield a product which is a compound of formula (I). Optionally, the dihydroxy groups may be derivatized as discussed above. ##STR31## 
     Synthesis of Dihydroxy Intermediate 
     Another aspect of the present invention is the preparation of the dihydroxy intermediate, 2 in Scheme II, from the addition of a cuprate to the diepoxide intermediate, 1,2,5,6-diepoxy-3,4-O-(alkylidene)hexane, represented by formula 1 in Scheme II. This is a novel process which is useful for the preparation of intermediates which are themselves useful for the preparation of compounds of formula (I). In practicing this aspect of the invention, a solution of an organometallic reagent in an organic solvent is added to a solution of a copper salt in an organic solvent in a reaction vessel. The resulting mixture is then stirred forming an organocuprate. Next, a solution of the diepoxide intermediate, 1,2,5,6-diepoxy-3,4-O-(alkylidene)hexane, represented by formula 1 in Scheme II, in an organic solvent is added to the formed organocuprate to give the dihydroxy product represented by formula 2 in Scheme II. This is stirred until the reaction is complete and is then subjected to a standard aqueous work-up, which isolates the desired product in an organic solvent. Evaporation of the organic solvent affords the desired product which is represented by formula 2  in Scheme II. If necessary, the product obtained from the practice of this aspect of the invention may purified using well known techniques. 
     The metal of the organometallic reagent can be lithium or magnesium. The preferred metal is lithium. The copper salt may be any copper salt which provides a source of copper(I). Preferred copper salts are copper(I) bromide, copper(I) chloride, copper(I) iodide and copper(I) bromide-dimethyl sulfide complex. Most preferred is copper(I) bromide-dimethyl sulfide complex. The solvent used in this process may be any aprotic solvent. Preferred solvents are dialkyl ethers and mixtures of dialkyl ethers with tetrahydrofuran. The solvent most preferred for use in this process is diethyl ether. The use of tetrahydrofuran by itself is not desirable. Solvents which are incompatible with this process are protic solvents. 
     In practicing this process it is important to rigorously exclude moisture and reactive gases such as oxygen and carbon dioxide. All reagents and solvents utilized in this process should be moisture free and free of reactive gases. The reaction vessels and containers should be similarly free of moisture and reactive gases. The reaction should be performed under an atmosphere of an inert gas such as nitrogen or argon. 
     In practicing this aspect of the invention, the reaction may be carried at over a temperature range of -78° to 25° C. The preferred temperature range is -78° to -20° C. It is desirable to add the solution of the organometallic reagent to the solution of the copper salt at about -20° C. After adding the 1,2,5,6-diepoxy-3,4-O-(alkylidene)hexane it is desirable to stir the resultant mixture at 0° C. The reaction may be carried out over a time period of 5 minutes to 18 hours. The usual reaction time is between 5 minutes and 1 hour. 
     If necessary, the compounds provided by this aspect of the invention may be purified by any technique useful for the purification of such compounds. Preferred methods include recrystallization and chromatography. 
     The intermediate represented by formula 5 in Scheme II may also be prepared according to the method shown in Scheme III. In this method, 1,2,5,6-diepoxy-3,4-O-(alkylidene)hexane is reacted sequentially with lithium bis(trimethylsilyl)amide, tetrabutylammonium fluoride and N-(benzyloxycarbonyl)succinimide to give the N-protected diaminodiol intermediate represented by formula 8 in Scheme III. This intermediate is then reacted with triphenylphoshine and diethyl azodicarboxylate to give the bisaziradine intermediate, 9. Finally, reaction of 9 with an organocuprate affords intermediate, 5, which can be further elaborated to compounds of formula (I) as shown in Scheme II. 
     Synthesis of Aziridines 
     Another aspect of the present invention is a novel process for the conversion of the N-protected diamino diol, represented by formula 8 in Scheme III, to the bisaziridine intermediate, 9. The process of the present invention is analogous to the Mitsunobu reaction and may be viewed as an intramolecular Mitsunobu reaction. The Mitsunobo reaction is a known method for the conversion of a hydroxy group to another functional group, e.g., to an amino group. Mitsunobu, O., Synthesis 1981, 1. The process of the present invention is distinguished from the known Mitsunobu reaction by being an intramolecular reaction which yields an aziridine. No references were found in the literature which disclose the synthesis of an aziridine ring via an intramolecular Mitsunobu reaction in which the amino group is protected with benzyloxy carbonyl. The Benzyloxy-carbonylgroup is readily deprotected by simple hydrogenolysis. Other protecting groups such as tosylamides are removed with difficulty and need drastic conditions. ##STR32## 
     In addition to the utility of this process for the preparation of bisaziridine intermediate 9 of Scheme III, it is also anticipated that this process will have utility for the synthesis of any molecule containing an aziridine ring. The only requirement which must be met in using this process for the synthesis of such molecules is that there be available a suitable precurser molecule which contains at least one functional group pair. A functional group pair is defined as a hydroxy group and an amino group beta to the hydroxy group. Practicing this process on a precurser molecule containing a single functional group pair would give rise to a product containing a single aziridine group. Practicing this process on a precurser molecule containing two functional pair groups, such as formula 8 of Scheme III, gives a product containing two aziridine groups. Similarly, precurser compounds with three or four functional group pairs would give products containing three or four aziridine groups respectively. 
     In practicing this aspect of the invention, diethyl azodicarboxylate is added to a solution of the precurser molecule, e.g., compound 8 in Scheme III, and triphenylphoshine in an anhydrous organic solvent. The reaction is stirred and its progress is monitored by thin layer chromatography (10:1:10, ethyl acetate/ethyl alcohol/hexane) until it is complete. The reaction mixture is then concentrated to a small volume and the product is purified, if necessary. 
     The ratio of triphenyl phosphine:diethyl azodicarboxylate:diol utilized in this process may be 1-4:1-4:1 respectively. A preferred ratio of reagents is 1-2:1-2:1. The most preferred ratio is 1:1:1. 
     The process requires the use of a reaction solvent. Polar aprotic solvents may be used. Preferred solvents include tetrahydrofuran, benzene and toluene. The most preferred solvent is tetrahydrofuran. Protic solvents are incompatible with this process. 
     In practicing this process it is important to rigorously exclude moisture and reactive gases such as oxygen and carbon dioxide. All reagents and solvents utilized in this process should be moisture free and free of reactive gases. The reaction vessels and containers should be similarly free of moisture and reactive gases. The process should be performed under an atmosphere of an inert gas such as nitrogen or argon. 
     This process operates over a temperature range of 25° to 85° C. The preferred temperature range is 55° to 85° C. The most preferred temperature range is 70° to 85° C. 
     The process may be carried out over a time range of 5 minutes to 24 hours. The process is usually carried out over a time range of 5 minutes to 30 minutes. 
     The aziridine products provided by this aspect of the invention can be further purified, if necessary, by recrystallization or chromatography. 
     It is further anticipated that this process would be useful for the preparation of saturated 3-7 membered nitrogen containing heterocycles by carrying out an intramolecular Mitsunobo reaction on a precurser molecule containing a protected nitrogen atom and a hydroxyl group separated by 2-6 atoms. 
     Hydrogenation of Bis(N-CBZ)-diaminodiols 
     The compounds of formula (I) obtained by any of the above methods can be further elaborated to give other compounds of formula (I). For example, compounds of formula (I) which are bis(N-CBZ)-diaminodiols can be hydrogenated to remove the CBZ protecting group and give the corresponding diaminodiol which may then be further elaborated at the amine residues. The hydrogenation to remove the CBZ protecting group can be carried out using any of the catalysts, solvents and reaction conditions commonly employed to effect removal of this group. A preferred method is to take up the bis(N-CBZ)-diaminodiol in a minimum amount of tetrahydrofuran to permit some solubility, add one volume of ethanol, and optionally 1°-100° volume % acetic acid, and 0.1 weight equivalents of 10% palladium on carbon, and stir under hydrogen at ambient temperature and pressure for 24  hours, occasionally evacuating the reaction flask and refilling with hydrogen. The reaction mixture is worked-up using standard techniques and, if necessary, the diaminodiol obtained is further purified. 
     Coupling of Diaminodiols 
     The diaminodiols of formula (I) obtained as described above or from any other source can be further elaborated by reacting them with any one of the many known electrophiles. Coupling reactions of the diaminodiols with activated esters are a particularly useful method for elaborating these compounds. Many conditions and reagents are available to effect coupling. Some preferred methods are exemplified in the Example section. For example, the diaminodiols of formula (I) can be reacted with suitably protected peptides, suitably protected amino acids or carboxylic acids in the presence of dicyclohexylcarbodiimide (DCC) and 1-hydroxybenzotriazole hydrate using procedures commonly employed in peptide synthesis to give the corresponding diamidodiol. The diaminodiols of formula (I) can be reacted with suitably protected peptides, suitably protected amino acids or carboxylic acids in the presence of Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate (BOP) to give the corresponding diamidodiol. The diaminodiols of formula (I) can be coupled with carbonyldiimidazole. The diaminodiols of formula (I) can be reacted with activated esters such as N-hydroxysuccinimide esters and p-nitrophenylesters to give the corresponding diamidodiol. The diaminodiols of formula (I) can be reacted with isocyanates to give the corresponding urea. The diaminodiols of formula (I) can be reacted with epoxides to give the corresponding addition product. 
     Biochemistry 
     The compounds of formula (I) prepared were then tested as described herein to determine their ability to inhibit HIV protease activity. 
     It is believed the antiviral compounds of this invention can be administered as treatment for viral infections by any means that produces contact of the active agent with the agent&#39;s site of action in the body of a mammal. They can be administered by any conventional means available for use in conjunction with pharmaceuticals, either as individual therapeutic agents or in a combination of therapeutic agents. They can be administered alone, but generally administered with a pharmaceutical carrier selected on the basis of the chosen route of administration and standard pharmaceutical practice. 
     The dosage administered will, of course, vary depending upon known factors, such as the pharmacodynamic characteristics of the particular agent and its mode and route of administration; the age, health and weight of the recipient; the nature and extent of the symptoms; the kind of concurrent treatment; the frequency of treatment; and the effect desired. A daily dosage of active ingredient can be expected to be about 0.001 to 1000 milligrams per kilogram of body weight. 
     Dosage forms (compositions suitable for administration contain from about 1 milligram to about 100 milligrams of active ingredient per unit. In these pharmaceutical compositions the active ingredient will ordinarily be present in an amount of about 0.5-95% by weight based on the total weight of the composition. 
     The active ingredient can be administered orally in solid dosage forms, such as capsules, tablets, and powders, or in liquid dosage forms, such as elixirs, syrups, and suspensions. It can also be administered parenterally, in sterile liquid dosage forms. 
     Gelatin capsules contain the active ingredient and powdered carriers, such as lactose, starch, cellulose derivatives, magnesium stearate, stearic acid, and the like. Similar diluents can be used to make compressed tablets. Both tablets and capsules can be manufactured as sustained release products to provide for continuous release of medication over a period of hours. Compressed tablets can be sugar coated or film coated to mask any unpleasant taste and protect the tablet from the atmosphere, or enteric coated for selective disintegration in the gastrointestinal tract. 
     Liquid dosage forms for oral administration can contain coloring and flavoring to increase patient acceptance. 
     In general, water, a suitable oil, saline, aqueous dextrose (glucose), and related sugar solutions and glycols such as propylene glycol or polyethylene glycols are suitable carriers for parenteral solutions. Solutions for parenteral administration preferably contain a water soluble salt of the active ingredient, suitable stabilizing agents, and if necessary, buffer substances. Antioxidizing agents such as sodium bisulfite, sodium sulfite, or ascorbic acid, either alone or combined, are suitable stabilizing agents. Also used are citric acid and its salts and sodium EDTA. In addition, parenteral solutions can contain preservatives, such as benzalkonium chloride, methyl- or propyl-paraben, and chlorobutanol. 
     Suitable pharmaceutical carriers are described in Remington&#39;s Pharmaceutical Sciences, A. Osol, a standard reference text in this field. 
     Useful pharmaceutical dosage-forms for administration of the compounds of this invention can be illustrated as follows: 
     Capsules 
     A large number of unit capsules are prepared by filling standard two-piece hard gelatin capsules each with 100 milligrams of powdered active ingredient, 150 milligrams of lactose, 50 milligrams of cellulose, and 6 milligrams magnesium stearate. 
     Soft Gelatin Capsules 
     A mixture of active ingredient in a digestable oil such as soybean oil, cottonseed oil or olive oil was prepared and injected by means of a positive displacement pump into gelatin to form soft gelatin capsules containing 100 milligrams of the active ingredient. The capsules are washed and dried. 
     Tablets 
     A large number of tablets are prepared by conventional procedures so that the dosage unit was 100 milligrams of active ingredient, 0.2 milligrams of colloidal silicon dioxide, 5 milligrams of magnesium stearate, 275 milligrams of microcrystalline cellulose, 11 milligrams of starch and 98.8 milligrams of lactose. Appropriate coatings may be applied to increase palatability or delay absorption. 
     EXAMPLES 
     Procedure I: Preparation of Intermediates ##STR33## 
     N-Carbobenzyloxyalanine (6.63 g, 29.7 mmol; Sigma Chemical Company) was dissolved in 30 mL THF in a 100 mL oven-dried flask under N 2  and stirred at room temperature while adding 1,1&#39;-carbonyl diimidazole (4.82 g, 29.7 mmol; Aldrich Chemical Company) neat. Copious bubbling occurred, indicating CO 2  formation. The mixture was stirred 30 minutes and (s)-2-amino-1-phenylpropanol (4.5 g, 29.7 mmol; Sigma Chemical Company) was added neat. Stirring was continued for 18 hours. The mixture was poured into a separatory funnel and the flask rinsed with dichloromethane. 100 mL of dichloromethane was added, and 50 mL saturated aqueous disodium-L-tartaric acid. The funnel was shaken, the aqueous layer removed, the organic layer washed with saturated bicarbonate and brine, and dried with magnesium sulfate. Filtration and solvent removal yielded a white solid. Recrystallization by dissolving in hot ethyl acetate, filtering, and adding hexane until cloudy provided 6.76 g (64%) white crystals with properties consistent with alcohol (III). 
     Melting Point: 120°-121° C. 
     NMR (300 MHz, CDCl 3 ); δ, ppm: 7.1-7.5 (m, 10 H); 6.45 (broad d, 1H, NH); 5.35 (d, 1H, NH); 5.1 (broad s, 2H, OCH 2  Ph); 4.1-4.2 (m, 2H, alanine a-CH); 3.6 (m, 2H, CH 2  OH); 2.85 (m, 2H, phenylalaninol b-CH 2 ); 1.2-1.4 (d, 3H, methyl). 
     Using the above conditions, the following a-aminoalcohols were prepared: ##STR34## 
     Melting Point: 158°-160° C. 
     NMR (300 MHz, CDCl 3 ): 7.1-7.6 (m, 10 H); 6.2 (broad d,1H, NH); 5.25 (d, 1H, NH); 5.1 (broad s, 2H, OCH 2  Ph); 4.2 (m, 1H, isoleucine a-CH); 3.95 (dd, 1H, isoleucine a-CH); 3.6 (m, 2H, CH 20  H); 2.85 (m, 2H, phenylalaninol b-CH 2 ); 1.85 (m, 2H, isoleucine methylene)1.3 (m, 1H, isoleucine methine); 0.8-1.1 (m, 6H, methyls). ##STR35## 
     Melting Point 173°-180° C. 
     NMR (300 MHz, DMSO-d6): (m, 7.65, 1H, NH); 7.2-7.-4 (11H, m, aromatic and NH); 5.05 (2H, m, OCH 2 ); 3.9 (m, 1H, CH 2  OH); 3.8 (dd, 1H, isoleucine a-CH); 3.35-3.5 (m, 2H, CH 2  OH); 2.6-2.9 (m, 2H, phenylalaninol b-CH 2 ); 1.6 (m, 2H, isoleucine methylene)1.3 (m, 1H, isoleucine methine); 0.8-1.1 (m, 6H, methyls). ##STR36## 
     Melting point 147.5°-149.5° C. 
     NMR (300 MHz, DMSO-d6): 7.65 (d, 1H, NH); 7.2-7.4 (6H, m, aromatic and NH); 5.05 (2H, m, OCH 2 ); 4.7 (dd, 1H, isoleucine a-CH); 3.8 (m, 1H, methionine a-CH); 3.25-3.4 (m, 2H, CH 2  OH); 2.3-2.5 (m, 2H, methione g-CH 2 ); 1.9 (s, 3H, SCH 3 ); and 0.7-1.9, aliphatics. ##STR37## 
     NMR (300 MH 2 , CDCl 3 ): 7.2-7.2 (m,10H, aromatic); 6.2 (d, 1H, NH); 5.1-5.2 (m, 3H, OCH 2 , NH); 4.15 (m, 1H, phenylalaninol a-CH) 3.95 (dd, 1H, valine a-CH); 3.5-3.7 (m, 2H, CH 2  OH); 2.8-2.9 (m, 2H, phenylalaninol β-CH 2 ); 2.1 (m, 1H, valine b-CH); 0.9 (d, 3H, methyl); 0.8 (d, 3H, methyl). 
     Procedure II: Synthesis of Aldehydes ##STR38## 
     A nitrogen-filled, oven-dried 500 mL flask was charged with 35 mL CH 2  C 12  and 2.90 g oxalyl chloride (25.25 mmol) under N 2  and cooled to -60. Dry dimethylsulfoxide (2.42 g, 33.6 mmol) in 40 mL CH 2  Cl 2  was added over about 10 min. The mixture was stirred 15 min at -60, and alcohol C (6.00 g, 16.8 mmol) was added in 100 mL 1:1 THF/CH 2  Cl 2 . After stirring 25 min at -60, triethylamine (6.8 g, 67.2 mmol) was added in 20 mL CH 2  C 12 . Stirred 30 min at -60 and quenched with 20% aqueous KHSO 4  (150 mL) at -60. A white solid formed as water froze. Added 180 mL hexane and warmed to RT. Separated aqueous layer and washed with ether. Combined organic layers, filtered off white solid (presumably unreacted, insoluble starting alcohol) and washed with sat. aq. NaHCO 3 , water and brine, and dried over MgSO 4 . Yield: 5.12 g white solid. Analytically pure sample can be obtained by recrystallization from EtOAc/hexane, but the aldehyde is very readily epimerized at the a-carbon, and a small amount of the S,R isomer is generally observed after workup or other manipulation. Additionally, variable amounts of aldehyde trimers oligermers may be observed if the aldehyde is exposed to strong acids in organic solvents. 
     Melting Point: 125°-126° C. 
     NMR (300 MH 2 , CDCl 3 ): 9.6 (br s, 1H, CHO); 7.1-7.4 (m, 10H, aromatic); 6.5 (br, 1H, NH); 5.1-5.2 (m, 3H, NH and OCH 2 ); 4.65 (m, 1H, phenylalaninal a-CH); 4.25 (m, 1H, alanine a-CH); 3.15 (m, 2H, phenylalaninal β-CH 2 ); 1.35 (d, 3H, CH 3 ). 
     Using the above procedure, the following aminoaldehydes were prepared: ##STR39## 
     Melting Point 116°-117° C. 
     NMR (300 MH 2 , CDCl 3 ): 9.6 (br s, 1H, CHO); 7.1-7.5 (m, 10H, aromatic); 6.45 (br d, 1H, NH); 5.1-5.2 (m, 3H, NH and OCH 2 ); 4.65 (m, 1H, phenylalaninal a-CH); 4.1 (m, 1H, isoleucine a-CH); 3.15 (m, 2H, phenylalaninal β-CH 2 ); 1.85 (m, 2H, isoleucine methylene) 1.4 (m, 1H, isoleucine β-CH 2 ); 0.8-1.1 (m, 6H, methyls). 
     MS (FAB): M+H (measured) 397.21; (calculated) 397.17 ##STR40## 
     NMR (300 MH 2 , CDCl 3 ): 9.6 (br s, 1H, CHO); 7.1-7.4 (m, 10H, aromatic); 6.4 (br d, 1H, NH); 5.1-5.2 (m, 3H, NH and OCH 2 ); 4.75 (m, 1H, phenylalaninal a-CH); 4.0 (m, 1H, valine a-CH); 3.15 (m, 2H, phenylalaninal β-CH 2 ); 2.1 (m, 1H, valine β-CH); 0.8-1.0 (m, 6H, methyls). 
     MS (FAB): M+H (measured) 383.13; (calculated) 383.20 ##STR41## 
     NMR (300 MH 2 , CDCl 3 ): 9.6 (br s, 1H, CHO). ##STR42## 
     NMR (300 MH 2 , CDCl 3 ): 9.6 (br s, 1H, CHO); 7.1-7.5 (m, 10H, aromatic); 6.45 (br d, 1H, NH); 5.1-5.2 (m, 3H, NH and OCH 2 ); 4.7 (m, 1H, 4-chlorophenylalaninal a-CH); 4.1 (m, 1H, isoleucine a-CH); 3.1 (m, 2H, 4-chlorophenylalaninal β-CH 2 ); 1.85 (m, 2H, isoleucine methylene) 1.4 (m, 1H, isoleucine β-CH 2 ); 0.8-1.1 (m, 6H, methyls). ##STR43## 
     NMR (300 MH 2 , DMSO-d6; mixture of isomers; major isomer): 9.4 (s, 1H, CHO). 
     Procedure III: Preparation of Aldehydes 
     Method A ##STR44## 
     1,1-Dimethylethyl 1-formyl-2-phenylethylcarbamate 
     Step 1: A solution of 11.0 g (41.5 mmol) of N-tertbutoxycarbonyl-L-phenylalanine (Sigma Chemical Co., St. Louis, Mo.) in 100 mL of CHCl 3  at 0° C. was treated with 4.6 mL of N-methylmorpholine followed by 5.4 mL of isobutylchloroformate. After stirring for 10 minutes the reaction mixture was treated with 4.05 grams of N,O-dimethylhydroxylaminehydrochloride followed by 5.8 mL of triethylamine. Upon stirring at 0° C. for 1 hour followed by 16 hours at room temperature, the reaction mixture was worked up by washing with 2×50 mL of 0.2N HCl, 2×50 mL of 0.5N NaOH and 50 mL of saturated NaCL. The organic layer was dried with MgSO 4  and concentrated under reduced pressure to yield 12.4 grams of an oil which was used in the next step without further purification. This material showed NMR (CDCl 3 ): 1.4 (s, 9H), 3.0 (m, 2H), 3.2 (s, 3H), 3.65 (s,3H), 4.95 (m, 1H), 5.2 (m, 1H), 7.2 (m,5H); MS cal 309.18 f 309.33. 
     Step 2: The above material was dissolved in 250 mL of ether, cooled to 0° C. and treated with 9.5 grams (250 mmol) of lithium aluminum hydride. After warming to room temperature and stirring for 1 hour the reaction was quenched with a solution of 0.35 mole KHSO 4  in 200 mL of water. The organic layer was separated and the aqueous layer was extracted with 200 mL of ether. The combined ether layers were washed with 2×100 mL 10% HCl, 100 mL NaHCO 3  and dried over MgSO 4 . Upon concentration under reduced pressure, 9.8 g of a pale yellow oil was obtained which solidified upon standing in the refrigerator. The product showed NMR(CDCl 3 ): 1.4 (s, 9H), 2.9 (m, 2H),7.2 (m,5H), 9.6 (s,1H). 
     A sample prepared in another experiment was purified by chromatography to yield a pure sample which showed the following NMR (CDCL 3 ): 1.4(S&lt;9H), 3.1 (d,J=10HZ,2H), 4.4 (m,1H), 5.05 (m,1H), 7.05 (m,5H), 9.6(s,1H). 
     Method B ##STR45## 
     1,1-Dimethylethyl 1-formyl-4-thia-pentylcarbamate 
     Step 1: A method similar to that reported in Organic Synthesis, volume 67, 69 (1988) was used. Thus, 9.75 grams of N,O-dimethyhydroxylamine hydrochloride in 60 mL of CH 2  C 12  was cooled below 5° C. and treated with 7.35 mL of triethylamine through an addition funnel to keep the temperature below 5° C. This material was maintained below 5° C. and added to the reaction mixture 2 minutes after the addition of 7.73 mL of methylchloroformate to a solution at -20° C. of 24.9 grams of N-tert-butoxycarbonyl-L-methionine (Sigma Chemical Co., St. Louis, Mo.) in 400 mL of CH 2  C 12  containing 10.97 mL of N-methylmorpholine. After the addition, the reaction mixture was warmed to room temperature and stirred for 4 hours. At the end of this period the reaction mixture was worked up as described above (Method A, Step 1) to yield 24.39 grams of an oil which was used in the next step without further purification. The product showed NMR(CDCl 3 ): 1.4 (s,9H), 1.95 (m, 2H), 2.55 (t, J=8Hz, 2H), 2.8 (s, 6H),4.35 (m,1H). 
     Step 2: This material was dissolved in 80 mL of ether and added to a suspension of 4.5 grams of lithium aluminum hydride in 400 mL of ether at -45° C. at such a rate that the temperature remained below -35° C. Upon completion of the addition, the reaction mixture was warmed to 5° C., then cooled to -35° C. and treated with 24.85 grams of NaHSO 4  in 65 mL of water at such a rate that temperature was below 2° C. The resulting slurry was stirred for 1 hour and then filtered through a pad of celite. The celite pad was washed with 2×100 mL of ether and the combined ether layers were washed with 3×100 mL of 1N HCl, 2×100 mL NaHCO 3  and 100 mL of saturated NaCl. The organic layer was dried over MgSO4 and concentrated under reduced pressure to yield 17.67 grams of an oil which was used without further purification. The product showed NMR (CDCl 3 ): 1.4 (S, 9H), 1.9 (m,2H), 2.08 (s, 3H), 2.55 (t, J=10Hz, 2H), 4.25 (m, 1H), 5.2 (m, 1H). 
     The following aldehydes were prepared by the method of Method B: 
     1,1-Dimethylethyl 2-oxoethylcarbamate ##STR46## 
     NMR (CDCl 3 ): 1.45 (S, 9H), 4.05 (d, J=8Hz, 2H), 5.3 (m, 1H), 9.65 (s, 1H). 
     1,1-Dimethylethyl 1-formylethylcarbamate: ##STR47## 
     NMR (CDCl 3 ): 1.35 (d, J=10Hz, 3H), 1.45 (s, 9H), 4.2 (m, 1H), 5.15 (m, 1H), 9.55 (s, 1H). 
     1,1-Dimethylethyl 1-formyl-2-methylpropylcarbamate ##STR48## 
     NMR (CDCl 3 ): 0.95 (d, J=7Hz, 1.5H), 1.05 (d, j=7Hz, 1.5H), 1.45 (S, 9H), 2.3 (m, 1H), 4.25 (m, 1H), 5.15 (m, 1H), 9.65 (s, 1H). 
     1,1-Dimethylethyl 1-formyl-3-methylbutylcarbamate ##STR49## 
     NMR (CDCL 3 ): 0.95 (m, 6H), 1.4 (s, 9H), 1.6 (m, 1H), 4.2 (m, 1H), 5.0 (m, 1H) 9.55 (s, 1H). 
     1,1-Dimethylethyl 2-formyl-1-pyrrolidinecarbamate ##STR50## 
     1.48 (s, 9H), 1.72-2.20 (m, 4H), 3.23-3.72 (m, 3H) 
     1,1-Dimethylethyl 2-oxoethyl-1-phenylcarbamate ##STR51## 
     NMR (CDCL 3 ): 1.4 (s), 7.2 (m), 9.45 (s). 
     Benzyl 1-formyl-2-phenylethylcarbamate ##STR52## 
     NMR (CDCl 3 ): 3.15 (d, J=6Hz, 2H), 4.5 (d, j=12.6Hz, 1H), 5.1 (s, 2H), 5.35 (m, 1H), 7.1-7.4 (m, 10H), 9.6 (s, 1H). 
     1,1-Dimethylethyl 1-formyl-3-phenylpropylcarbamate ##STR53## 
     NMR (CDCL 3 ): 1.45 (s, 9H), 1.9 (m, 2H), 2.75 (m, 2H), 4.25 (m, 1H), 5.1 (m, 1H), 7.2 (m, 5H), 9.55 (s, 1H). 
     1,1-Dimethylethyl 1-formyl-2-(4-fluorophenyl)ethylcarbamate ##STR54## 
     NMR (CDCL 3 ): 1.45 (s, 9H), 3.1 (m, 2H), 4.4 m, 1H), 5.05 (m, 1H), 7.0 (m, 4H), 9.65 (s, 1H). 
     1,1-Dimethylethyl 1-formyl-2-(4-iodophenyl)ethylcalrbamate ##STR55## 
     NMR (CDCL 3 ): 1.4 (s, 9H), 3.1 (m, 2H), 4.4 (s, 1H), 5.1 (m, 1H), 6.9 (d, j=8Hz, 1H), 7.2 (m, 2H), 7.6 (d, j=8Hz, 1H), 9.6 (s, 1H). 
     1,1-Dimethylethyl 1-formyl-2-(4-benzyloxyphenyl)ethylcarbamate ##STR56## 
     NMR (CDCl 3 ): 1.45 (s,9H), 3.05 (d, J=12Hz, 2H), 4.4 (m, 1H), 5.05 (s, 2H), 6.9 (d, J=12Hz, 2H), 7.05 (d, j=12Hz, 2H), 7.3 (m, 5H),9.6 (s,1H). 
     Coupling of Aldehydes With Caulton&#39;s Reagent 
     EXAMPLE 1A AND 1B ##STR57## 
     Bis (1,1)-dimethylethyl) (2,3-dihydroxy-1,4-bis(2-(methylthio)ethyl)-1,4-butanediyl)biscarbamate 
     To a solution of 1,1-dimethylethyl 1-formyl-4-thiabutylcarbamate, from Method B, in 1 mL of CH 2  Cl 2 , under argon, was added 5 mL of the Caultons reagent (prepared via the method reported by Bouma et al, Inorg. Chem., 23, 2715-2718 (1984)) followed by 10 drops of DMF. After stirring over night the reaction mixture was treated with 1 mL of 20% KOH, filtered through celite and the celite pad was rinsed with CH 2  Cl 2 . The organic layer was separated from the combined filtrates, dried and concentrated under reduced pressure to afford the crude product. This material was chromatographed over silica gel using 20% EtOAc/hexane to afford a fraction containing 33.6 mg of an isomer of the desired product as a crystalline solid. A second fraction was found to contain 12 mg of another isomer of the desired product as a crystalline solid (Example 1B,). Example 1B had MS: cal 469.24 F 469.19. 
     EXAMPLE 2A ##STR58## 
     Bis(1,1-dimethylethyl) (2,3-dihydroxy-1,4-(phenylmethyl)-1,4-butanediyl)biscarbamate (1S,2S,3S,4S) 
     A solution of 1.06 g 1,1-dimethylethyl 1-formyl-2-phenylethylcarbamate, from Method A, in 10 mL of CH 2  Cl 2 , was treated with 3 mL of DMF followed by 10 mL of Caulton&#39;s reagent and stirred for 16 hour. At the end of the period the reaction mixture was treated with 10 mL of 20% NaOH, stirred for 15 minutes and then diluted with 50 mL of ether. After filtering through a celite pad, the celite pad was washed with 3×50 mL of ether and the organic layer was separated from the filtrate. Upon washing with 2×20 mL of NaCl solution, drying over Na 2  SO 4  and concentration under reduced pressure the organic layer gave a crude product which was chromatographed over 50 grams of silica gel using 2:1 Hex:EtOAc as eluant. This afforded 0.35 g of the desired product. mp=210-213; NMR: (CDCl 3 ) 1.4 (s,18H), 3.0 (dd,J=10 Hz,2H), 3.2 (m 4H), 4.05 (m,2H), 4.4 (m,4H), 7.2 (m,10H). Upon D 2  O exchange, the multiplet at 4.4 became a doublet (d, J=10 Hz, 4H); MS Cal 501.3 F500.85; Anal Cal C: 67.18, H: 8.05, N: 5.60 F C: 66.92, H: 8.31, N: 5.64. The product of this reaction had the stereochemistry, 1S,2S,3S,4S; this was determined as described below. 
     The stereochemistry of each of the nitrogen bearing carbon atoms is known to be S since the starting material was the L-isomer. The stereochemistry of the hydroxy bearing carbon atoms was determined by conversion of the diol to its corresponding oxazolidinone and measuring the coupling constant between the ring protons. See J. Med. Chem. 30, 1978-83 (1987). The procedure was carried out as follows: to 100 mg of the diol, 4 mL of 4N HCl in dioxane was added and after stirring for 15 min the volatile material was evaporated by blowing nitrogen. Upon subjecting the residual product to high vacuum under KOH it was dissolved in 4 mL of CHCl 3 , cooled to 0° C. and 0.28 mL of triethylamine was added. To this, 0.206 mL of 10% phosgene solution in toluene was added and stirred for 16 hour. At the end of this period the reaction mixture was diluted with 75 mL of EtOAc, washed with 10 mL 1N HCl, 10 mL of NaHCO 3 , dried and concentrated under reduced pressure to give a product which was purified by flash chromatography to give 22.3 mg of the desired oxazolidinone that crystallized to afford 15.8 mg of material. NMR (CDCl 3 ) of this material showed a coupling of 7.5 Hz between the protons attached to the oxygen and nitrogen bearing carbon atoms. This coupling constant is consistent with each of the hydroxy bearing carbons being in the S configuration. Thus, this molecule was assigned the stereochemistry 1s,2s,3s,4s. 
     EXAMPLE 2B ##STR59## 
     Bis(1,1-dimethylethyl) (2.3-dihydroxy-1,4-(phenylmethyl)-1,4)-butanediyl)biscarbamate (1S,2R,3R,4S) 
     To 10 mL of Caulton&#39;s reagent, 1.06 g (4 mmol) of 1 1-formyl-2-phenylethylcarbamate, from Method A, was added and after all the aldehyde dissolved 3 mL of DMF was added. The reaction mixture was then treated in a manner similar to Example 2A to give 0.41 g of the desired compound as a solid mp 202°-204°, NMR(CDCl 3 ): 1.4 (s, 18H), 2.9 (m, 4H), 3.4 (s, 2H), 4.0 (s, 2H), 4.8 (d, J=10Hz, 2H), 7.2 (m, 10H). MS cal. 501.3 Found 501.05. Elemental Analysis cal C:67.18, H:8.05, N:5.60; Found C:66.94, H:8.15, N:5.60. This material was shown to have the stereochemistry 1s,2r,3r,4s by the method described in Example 2A; the oxazolidinone produced showed a coupling constant of 5.5 Hz between the protons attached to oxygen and nitrogen bearing carbon atoms. 
     EXAMPLE 2C ##STR60## 
     Bis(1,1-dimethylethyl) (2,3-dihydroxy-1,4-(phenylmethyl)-1,4-butanediyl)biscarbamate (1S,2S,3R,4S) 
     The 1s,2s,3r,4s isomer was prepared by adding a solution of 1.0013 grams of 1,1-Dimethylethyl 1-formyl-2-phenylethylcarbamate, from Method A, in 2 mL of dry CH 2  Cl 2 , to 15 mL of Caulton&#39;s reagent followed by 3 mL of DMF. This was stirred for 16 h, treated with 10 mL of 20% KOH solution and stirred for 1 hour and filtered through a pad of celite. The organic layer from the filtrate was dried with Na2SO 4  and concentrated under reduced pressure to give a crude product. This material was chromatographed over 80 grams of silica gel eluting with 20% EtOAc to give 0.166 g of product, mp=172°-174° C. MS: calcd. 501.30, found 501.66. 
     EXAMPLE 2D ##STR61## 
     Bis(1,1-dimethylethyl) (2,3-dihydroxy-1,4-(phenylmethyl)-1,4-butanediyl)biscarbamate (1S,2R,3R,4S) 
     To 0.997 gram (4 mmol) of 1,1-dimethylethyl 1-formyl-2-phenylethylcarbamate, from Method A, under argon, 10 mL of dry CH 2  Cl 2  was added and after all the aldehyde has dissolved 10 mL of Caulton&#39;s reagent was added. The reaction was then treated in a manner similar to that described in Example 16 to give 0.332 g of the desired product with NMR identical to that of Example 2B. 
     EXAMPLE 3 ##STR62## 
     Bis(1,1-dimethylethyl) (2,3-dihydroxy-1,4-butanediyl)biscarbamate 
     1,1-Dimethylethyl 2-oxoethylcarbamate was couple a described in Example 2B to give from 0.997 grams of the aldehyde 39 mg of the desired product. NMR (CDCl 3 , D 2  O) 1.45 (s, 18H), 3.2-3.5 (m, 4H), 3.6 (t, J=10Hz, 4H), 5.15 (m, 2H); MS Calcd 321.20, F321.29. 
     EXAMPLE 4 ##STR63## 
     Bis(1,1-dimethylethyl) (2,3-dihydroxy-1,4-dimethyl-1,4-butanediyl)biscarbamate 
     1,1-Dimethylethyl 2-oxoethylcarbamate was coupled as described in Example 2B to give from 0.693 g of the aldehyde 0.342 g of the desired product. NMR (CDCl 3 , D 2  O): 1.2 (d, J=10Hz, 6H), 1.4 (s, 18H), 3.35 (s, 2H), 3.85 (m, 2H), 4.95 (m, 2H); MS Calcd 349.23; F 349.35. 
     EXAMPLE 5 ##STR64## 
     Bis(1,1-dimethylethyl) (2,3-dihydroxy-1,4-(1-methylethyl)-1,4-butanediyl)biscarbamate 
     1,1-Dimethylethyl 1-formyl-2-methylpropylcarbamate was coupled as described in Example 2D to give, from 0.845 g of aldehyde, 0.160 g of the desired product, mp 156-159; NMR (CDCl 3 , D 2  O): 1.0 (d, J=10Hz) 1,45 (s, 18H), 2.0 (m, 2H), 3.2 (t, J=10Hz, 2H), 3.65 (s, 2H),5.0 (d, J=10Hz, 2H). 
     EXAMPLE 6 ##STR65## 
     Bis(1,1-dimethylethyl) (2,3-dihydroxy-1,4-(2-methylpropyl)-1,4-butanediyl)biscarbamate 
     1,1-Dimethylethyl 1-formyl-3-methylbutylcarbamate was coupled as described in Example 2D to give, from 0.933 g of the aldehyde, 0.1799 g of the desired product, mp 152-153, NMR (CDCl 3 , D 2  O): 0.95 (m,12H), 1,4 (s,18H),1.6-1.8 (m, 6H), 3.2 (s, 2H), 3.8 (m, 2H), 4.95 (m, 2H); Elemental Analysis: Cal C:61.08 H:10.25 N:6.48; Found C:60.79 H:10.31 N:6.51; Ms Cal 433.33 F 432.96. 
     EXAMPLE 7 ##STR66## 
     Bis(1,1-dimethylethyl) 2,2&#39;-(1,2-dihydroxy-1,2-ethanediyl)-1-bis(pyrrolidinecarboxylate) 
     1,1-Dimethylethyl 2-formyl-1-pyrrolidinecarbamate was coupled as described in Example 2D to give, from 1.99 grams of the aldehyde, 1.14 grams of the desired product. NMR (CDCl 3 ) 1.45 (s, 18H), 1.6-2.0 (m, 8H), 3.35 (m, 2H), 3.45 (m, 2H), 3.6 (m, 2H), 3.95 (m, 2H); MS Calc 401.27 Found 401.34. 
     EXAMPLE 8 ##STR67## 
     Bis (1,1-dimethylethyl) (2,3-dihydroxy-1,4-diphenyl-1,4-butanediyl)biscarbamate 
     1,1-Dimethylethyl 2-oxoethyl-1-phenylcarbamate was as described in Example 2D to give, from 1.13 grams of the aldehyde, 0.51 grams of the product which upon crystallization from EtOAc gave 0.089 g of the desired product. NMR (CDCl 3 , D 2  O): 1.4 (s, 9H), 3.8(m, 2H), 7.2 (m, 5H); MS Calcd 473.27 Found 473.35. 
     EXAMPLE 9 ##STR68## 
     Bis(Dimethylethyl) (2,3-dihydroxy-1,4-(phenylmethyl)-1,4-butanediyl)biscarbamate 
     Benzyl 1-formyl-2-phenylethylcarbamate was coupled as described in Example 2D to give, from 2.02 grams of the aldehyde, 0.407 grams of the desired product, mp 201°-205° C.; NMR (DMSO-d 6 ) 2.7 (m, 4H), 3.3 (s, 2H), 4.2 (m, 4H), 7.2 (m, 2OH). Material prepared in another similar experiment showed MS Cal 569.27 Found 569.31. 
     EXAMPLE 10 ##STR69## 
     Bis(1,1-dimethylethyl) (2,3-dihydroxy-1,4-(2-phenylmethyl)-1,4-butanediyl)biscarbamate 
     1,1-Dimethylethyl 1 -phenylpropylcarbamate was coupled as described in Example 2D to give, from 2.86 grams of the aldehyde, 0.75 grams of the desired product, mp 174°-175° C. NMR (CDCl 3 , CD 3  OD): 1.35 (s,18H), 1.8 (m, 4H), 2.6 (t, J=10Hz, 4H), 3.4 (s, 2H), 3.6 (m, 2H), 7.1 (m, 10H); MS Cal 529.33 Found 529.44. 
     EXAMPLE 11 ##STR70## 
     Bis(1,1-dimethylethyl) (2,3-dihydroxy-1,4-(4-fluorophenyl)methyl)-1,4-butanediyl)biscarbamate 
     1,1-Dimethylethyl 1-formyl-2-(4-fluorophenyl)ethylcarbamate was coupled as described in Example 2D to give, from 2.99 grams of the aldehyde, 1.38 grams of the desired product, which upon crystallization afforded 0.172 g of a solid mp 189°-91° C., NMR (CDCl 3 , D 2  O): 1.3 (2 peaks), 2.8 (m, 4H), 3.4 (m, 2H), 3.7 (m, 2H), 7.0 (m, 10H); MS calcd 537.28 Found 537.41. 
     EXAMPLE 12 ##STR71## 
     Bis(1,1-dimethylethyl) (2,3-dihydroxy-1,4-(4fluorophenyl)methyl)-1,4-butanediyl)biscarbamate 
     1,1-Dimethylethyl 1-formyl-2-(4-iodophenyl)ethylcarbamate was coupled as described in Example 2D to give, from 1.13 grams of aldehyde, 0.66 grams of the desired product, mp 191-194 NMR (CDCl 3 ): 1.3 (s, 18H), 2.8 (m, 4H), 3.4 (m, 2H), 3.7(m,2H), 6.95 (d, J=10Hz, 2H), 7.2 (m, 4H), 7.55 (d, J=10Hz, 2H). 
     EXAMPLE 13 ##STR72## 
     Bis(1,1-dimethylethyl) (2,3-dihydroxy-1,4-(4-hydroxyphenyl)methyl-1,4-butaneidyl)biscarbamate 
     1,1-Dimethylethyl 1-formyl-2-(4-benzyloxyphenyl)ethyl carbamate was coupled as described in Example 2B to give, from 1.42 g of the aldehyde, 0.238 g of the o-benzyl protected intermediate. This material was not characterized further but was subjected to the following conditions to remove the benzyl protecting group. It was dissolved in 20 mL of MeOH:EtOAc 1:1, treated with 50 mg of 10% Pd/C and H 2  gas was bubbled through for 3.5 hour. At the end of this period the reaction mixture was filtered through a celite pad and concentrated under reduced pressure to yield the crude product which was purified by chromatography over 25 grams of silica gel using 1:2 Hex:EtOAc to afford 62.3 mg of the desired product, mp 110-112; NMR (CDCl 3 ) 1.35 (s, 18H), 2.8 (m, 4H), 3.4 (s, 2H), 3.7 (m, 2H), 6.7 d,J=15Hz, 4H), 7.0 (d, J=15Hz, 4H); MS Calcd 533.29 F 532.82. 
     EXAMPLE 14 ##STR73## 
     N,N&#39;-((2,3-dihydroxy-1,4-(phenylmethyl)-1,4-butanediyl))bisacetamide 
     100 mg (0.2 mM) of bis (1,1-dimethylethyl) (2,3-dihydroxy-1,4-(phenylmethyl)-1,4-butanediyl)biscarbamate, (1S,2R,3R,4S), from Example 2D, was stirred in 2 ml of 4N HCl in dioxane. The dioxane and HCl were removed under vacuum and the residual material was taken up in 2 ml of CHCl 3 , and treated with 55 microliters of triethylamine and 57 microliters of acetic anhydride. The resultant mixture was stirred for one hour and was then worked up by diluting with 50 ml of ethyl acetate, washing the organic layer with IN HCl, saturated NaHCO 3 , and drying the organic layer over magnesium sulfate. Filtration and evaporation gave 92.7 mg of crude product. Preparative plate chromatography (with ethyl acetate as the eluant) gave 36.2 mg of product. 
     EXAMPLE 15 ##STR74## 
     2,5-Diamino-1,6-diphenyl-3,4-hexanediol dihydrochloride 
     20 mg of bis(1,1-dimethylethyl) (2,3-dihydroxy-1,4-(phenylmethyl)-1,4-butanediyl)biscarbamate, (1S,2S,3S,4S), from Example 2A, was treated with 2 ml of 4N HCl in dioxane. After stirring for 15 minutes, the HCl and dioxane were removed under vacuum. Thin Layer Chromatography (1:1, Hexane/Ethyl acetate) showed that all of the starting material was converted. Treatment with Ninhydrin demonstrated the presence of the amino groups. NMR showed that the Boc groups were gone. 
     EXAMPLE 16 ##STR75## 
     2,5-Diamino-1,6-diphenyl-3,4-hexanediol dihydrochloride 
     20 mg of Bis(1,1-dimethylethyl (2,3-dihydroxy-1,4-(phenylmethyl)-1,4-butanediyl)biscarbamate (1S,2R,3R,4S), from Example 2B, was treated as described in Example 15. 
     EXAMPLE 17 ##STR76## 
     2,5-Diamino-3,4-hexanediol dihydrochloride 
     20 mg of Bis(1,1-dimethylethyl) (2,3-dihydroxy-1,4-dimethyl-1,4-butanediyl)biscarbamate from Example 4 was treated as described in Example 15. 
     EXAMPLE 18 ##STR77## 
     Bis(Boc-Thr-Ala-Thr-Ala), N,N&#39;((2,3-dihydroxy-1,4-(phenylmethyl)-1,4-butanediyl))biscarbamate 
     29.4 mg of Bis(1,1-dimethylethyl) (2,3-dihydroxy-1,4-(phenylmethyl)-1.4-butanediyl)biscarbamate (1S,2S,3S,4S), from Example 2C, was reacted with Boc-Thr-Ala-Thr-Ala-O-Succinamide and triethylamine in 2 ml of acetonitrile. Filtration gave 0.1083 g of product which was tested without further purification. 
     EXAMPLE 19 ##STR78## 
     Alternative Synthesis of Product of Example 2B From D-Mannitol via Cuprate Addition 
     Synthesis of carbamic acid, ((2,3-dihydroxy-1,4-(phenylmethyl)-1,4-butanediyl))-bis-, bis(1,1-dimethylethyl) ester, (1S,2R,3R,4S) from d-mannitol: 
     1,6-Di-O-(p-toluenesulfonyl)-2,3-O-isopropylidene-D-mannitol 2 
     A solution of 6.667 g (30 mmol) of 2,3-O-isopropylidene-D-mannitol 1 (purchased from Aldrich Chemical Co.) in 30 mL pyridine was cooled to -20° C. and treated with 12.582 g (66 mmol) of p-toluenesulfonyl chloride and the stirring continued for 20 minutes at -20 C., 20 minutes at 0° C. and 20 minutes at room temperature. The reaction mixture was diluted with dichloromethane and washed with 1N HCl and saturated NaHCO 3 . The extract after drying over anhydrous magnesium sulfate was concentrated and the residue purified (325 g, silica gel column chromatography using 2:3 EtOAc: Hexane as the eluting solvent) to provide 10.425 g (66% yield) of compound 2. This material showed NMR (CDCl 3 ): d 1.278 (s, 6H), 2.458 (s, 6H), 3.783 (m, 4H), 4.095 (q, 2H, J AB  =10.66Hz, J Ax  =5.67Hz), 4.33 (q, 2H, J AB  =10.6Hz, J BX  =1.98), 7.35 (d, 2H, J=1.74Hz), 7.81 (d, 2H, J=1.76Hz). 
     1,2,5,6-Diepoxy-3,4-O-(isoproylidene)hexane 3 
     A solution of 10.425 g (19.65 mmol) of compound 2 in 200 mL of anhydrous methanol was cooled at 0° C. and treated with 10.86 g (78.58 mmol) of K 2  CO 3 . The ice bath was removed and the contents stirred at room temperature for 20 minutes. The mixture was filtered and the filtrate was concentrated. The residue was dissolved in dichloromethane and the extract was washed with water and brine. The residue after removal of the solvent was purified (200 g silica gel column using 1:5 EtOAc: Hexane as the eluting solvent) to provide 2.95 g (80% yield) of compound 3. This material showed NMR (CDCl 3 ) d 1.45 (s, 6H), 2.4 (q, 2H, J AB  =4.94Hz, J AX  =2.65Hz), 2.86 (q, 2H, J AB  =4.94Hz, J BX  =4.2Hz), 3.13 (m, 2H), 3.85 (dd, 2H, J 1  =2.3Hz, J 2  =1.46) 
     1,6-Diphenyl-3,4-O-isopropylidene-2,5-hexanediol 4 
     A suspension of 9.25 g (45 mmol) of cuprous bromide-dimethyl sulfide complex in 40 mL anhydrous ether was stirred at -20° C. and 1.8M 50 mL (1.8M, 90 mmol) solution of phenyllithium was added dropwise. The contents were stirred for 30 minutes at -20° C. and then warmed up to 0° C. A solution of 2.807 g of compound in 20 mL anhydrous ether was added to the above mixture and the contents stirred for 30 minutes at 0° C. The excess reagent was quenched with saturated ammonium chloride and warmed up to room temperature. The contents were then filtered and the filtrate and the washings were washed with water and brine. The ether extract after drying over anhydrous magnesium sulfate was concentrated and the residue was purified (150 g silica gel column using 1:5 followed by 1:4 EtOAc: Hexane as the eluting solvent) to provide 4.577 g (89%) of compound 4. This material showed NMR (CDCl 3 ): d 1.455 (s, 6H), 2.7 (q, 2H, J AB  =13.8Hz, J AX  =7.9Hz), 3.15 (q, 2H, J AB  =13.8Hz, J BX  =2.5Hz), 3.75 (m, 4H), 7.28 (m, 10H). 
     2,5-Diazido-1,6-diphenyl-3,4 -O-(isopropylidene)hexane 5 
     A solution of 900 mg (2.63 mmol) of compound 4, 2.76 g (10.52 mmol) of triphenylphosphine in 20 mL of dry tetrahydrofuran was stirred with 250 mg of molecular sieves 2A at -78° C. 22.9 mL (0.46M, 10.52 mmol) solution of hydrazoic acid in xylene was added to the above mixture and stirred for 5 minutes at -78° C. This was followed by the addition of 1.66 mL (10.52 mmol) of diethylazodicarboxylate. The mixture was then allowed to warm up to room temperature in the same bath and stirred for 18h. The excess reagents were quenched by the addition of 0.4 mL (10 mmol) of methanol at 0° C. After stirring the mixture for 30 minutes at room temperature, it was concentrated to a small volume and purified (33 g silica gel column using hexane followed by 1:40 EtOAc: Hexane as the eluting solvent) to provide 836 mg of mixture of 5 and undesired side products. The mixture was difficult to purify at this stage and used directly in the next step. 
     2,5-Diazido-1,6-diphenyl-3,4-hexanediol 6 
     A solution of 570 mg of the mixture (as mentioned in the previous experiment) in 5 mL of ethanol and 1.67 mL of water was stirred with 1.67 g of Bio-Rad AG-50-W-X8 acid exchange resin at 70° C. bath for 18 h. The contents were filtered and washed with methanol. The filtrate and the washings were combined and concentrated. The residue was extracted with dichloromethane and dried over anhydrous magnesium sulfate. The residue after removal of the solvent was purified (20 g silica gel column using 1:3 EtOAc: hexane as the eluting solvent) to provide 102 mg (11% yield from 4) of 6. This material showed NMR (CDCl 3 ): d 2.95 (q, 2H, J AB  13.7Hz, J AX  =7.9Hz), 3.06 (q, 2H, J AB  =13.7Hz, J BX  =6.3Hz), 3.55 (m, 2H), 3.62 (bs, 2H), 7.3 (m, 10H). 
     2,5-Diamino-1,6 -diphenyl-3,4-hexanediol-7 
     A solution of 67 mg (0.19 mmol) of 6 in 4 mL of methanol was stirred with 30 mg of 10% palladium on carbon under 1 atmospheric hydrogen pressure for 18 hours at room temperature. The mixture was filtered through a 0.45 micron Millipore filter and the residue washed with methanol. The filtrate and the washings were concentrated to provide 45 mg (79% yield) of 7. This material showed NMR (CDCl 3 ): d 2.64 (m, 8H), 7.283 (m, 10H). 
     2,5-(N,N-Di-tert-butoxycarbonyl)diamino-1,6-dipheny-3,4-hexanediol 8 
     A solution of 45 mg (0.015 mmol) of compound 7 in 2 mL of absolute ethanol was stirred with 152 mg (0.58 mmol) of N-(tert-butoxycarbonyl)phthalimide for 18 hours at room temperature. The reaction mixture was diluted with 20 mL water and extracted with three 20 mL portions of dichloromethane. The dichloromethane extract was washed with 0.3N NaOH and brine. The residue after removal of the solvent was purified (33 g silica gel coulmn using 7% isopropanol in hexane as the eluting solvent) to provide 26 mg of pure and 12 mg of slightly contaminated 8 (total yield 51%). 
     This material has identical spectral data with the compound described in Example 2B. 
     EXAMPLE 19B 
     Alternative Synthesis of Product of Example 2B From D-Mannitol via Cuprate Addition 
     (2S,3R,4R,5S)-1,2,5,6-Diepoxy-3,4-O-(isopropylidene)hexane 1: This compound was prepared following the literature procedure (Y. L. Merrer et al, Heterocycles, 25, 541, 1987). This material showed NMR (CDCl 3 ): d 1 45 (s, 6H), 2.4 (q, 2H, J AB  =4.94Hz, J AX  =2.65Hz), 2.86 (q, 2H, J AB  =4.94Hz, J BX  =4.2Hz), 3.13 (m, 2H), 3.85 (dd, 2H, J 1  =2.3Hz, J 2  =1.46) 
     (2S,3R,4R,5S)-1,6-Diphenyl-3,4-0-isopropylidene-2,5-hexanediol 2: A suspension of 18.5 g (90 mmol) of cuprous bromide-dimethyl sulfide complex in 80 mL anhydrous ether was stirred at -20° C. and 1.8M 100 mL (1.8M, 180 mmol) solution of phenyllithium was added dropwise. The contents were stirred for 30 minutes at -20° C. and then warmed up to 0° C. A solution of 5.614 g of compound in 40 mL anhydrous ether was added to the above mixture and the contents stirred for 30 minutes at 0° C. The excess reagent was quenched with saturated ammonium chloride and warmed up to room temperature. The contents were then filtered and the filtrate and the washings were washed with water and brine. The ether extract after drying over anhydrous magnesium sulfate was concentrated and the residue was purified (325 g silica gel column using 1:10 followed by, 1:5 followed by 1:4 EtOAc: Hexane as the eluting solvents) to provide 8.035 g (78%) of compound 2. This material showed NMR (CDCl 3 ): d 1.455 (s, 6H), 2.7 (q, 2H, J AB  =13.8Hz, J AX  =7.9Hz), 3.15 (q, 2H, J AB  =13.8Hz, J BX  =2.5Hz), 3.75 (m, 4H), 7.28 (m, 10H). 
     (2S,3R,4R,5S)-2,5-Diazido-1,6-diphenyl-3,4-O-(isopropylidene)hexane 3: A solution of 16.781 g (49.00 mmol) of compound 2, 38.6 g (147 mmol) of triphenylphosphine in 300 mL of dry tetrahydrofuran was cooled in an ice bath and 23.1 ml (147 mmol) of diethylazodicarboxylate was added to the stirred mixture behind shield. 31.7 mL (147 mmol) of diphenylphosphorylazide (Caution--this reagent should be stored at 0° C. and handled with care. Some azides may be explosive!) was added to the above mixture and the contents were further stirred at 0° C. for 5 minutes. The mixture was then allowed to warm up to room temperature in the same bath and stirred for 1 h. TLC in 1:5 ethyl acetate/hexane indicates disappearance of compound 2 and formation of 3. The excess reagents were quenched by the addition of 6.0 mL (150 mmol) of methanol at 0° C. After stirring the mixture for 30 minutes at room temperature, it was concentrated to a small volume (NOTE: do not concentrate to the extent that solids separate. Also small amount of dichloromethane is needed to keep the contents in solution while loading on silica gel column. Use of more than necessary amount of dichloromethane results inefficient separation.) and purified [800 g silica gel column using hexane (500 mL) followed by 1:40 EtOAc: Hexane (1000 mL) and finally 1:20 ethyl acetate/hexane elutes the desired compound (3000 mL)] to provide 15.523 g of mixture of 3 and undesired side products. The mixture was difficult to purify at this stage and used directly in the next step. 
     (2S,3R,4R,5S)-2,5-Diamino-1,6-diphenyl-3,4-O-(isopropylidene)hexane 4: The above material (15.523 g) was divided in 3 equal portions and each portion dissolved in 75 mL absolute ethanol, flushed with nitrogen and each portion stirred with 1.5 g of 10% palladium on carbon under hydrogen (hydrogen balloon) for 18h. TLC 1:10 ethyl acetate/hexane solvent indicates disappearance of starting material. (If incomplete add 0.5 g of 10% palladium on carbon and stir under fresh balloon of hydrogen). Combined yield of 12.516 g was obtained. 
     (2S,3R,4R,5S)-2,5-(N-(Benzyloxy)carbonyl)diamino)-1,6-diphenyl-3,4-O-(isopropylidene)hexane 5: A solution of 13.67 g (40.2 mmol) of compound 4 in 100 ml dimethylformamide was stirred in ice-bath and treated with 21.93 g (88 mmol) of benzyloxycarnonyloxysuccinimide. The ice-bath was removed and the contents were stirred for 18 hours at room temperature. The excess reagent was quenched by treatment with 0.61 ml (10 mmol). The contents were diluted with water and extracted with dichloromethane (3× of ethanolamine. The mixture after complete removal of solvents was purified (500 g silica gel column using 1:5 followed by 1:4 EtOAc:Hexane) to provide 20.457 g (83.6% yield) compound 5. 
     (2S,3R,4R,5S)-2,5-Di-(N-((Benzyloxy)carbonyl)amino)-3,4-dihydroxy-1,6-diphenylhexane 6:A solution of 20.457 g (33.61 mmol) of compound 4 in 50 ml 90% aqueous trifluoroacetic acid was stirred in ice-bath and then at room temperature. for 18h. The reaction mixture was poured with stirring in 560 ml of 1M ice-cold sodium hydroxide and then rest of the trifluoroacetic acid was quenched with sat. sodium bicarbonate. The precipitated solid was filtered dried under vacuum and crystallized from chloroform to provide 15.02 g (77% yield) of compound 6 (M. P. 209-210). 
     (2S,3R,4R,5S)-2,5-diamino-3,4-dihydroxy-1,6-diphenylhexane 7:A solution of 10.432 g (18.36 mmol) of compound 6 in 500 ml THF and 500 ml ethyl alcohol was stirred with 1.043 g of 10% palladium on carbon at room temperature. for 18h over 1 atmosphere hydrogen pressure. The mixture was filtered through celite pad and the filtrate was concentrated to provide 6.06 g yield) of compound 7. The oil was triturated with diethyl ether and the white solid was filtered and washed to provide pure 7 (M. P. 92-94). 
     EXAMPLE 19C 
     Alternative Synthesis of Aziridine Product of Example 2B From D-Mannitol via Biszairidine Intermediate 
     1,6-Di(N,-(benzyloxycarbonyl)amino)-2,5-dihydroxy-3,4-O-(isopropylidene)hexanediol 8 
     In a 250 mL Round Bottom Flask was placed 20 mL of 1M (20 mmol) of Lithium Bis (trimethylsilyl)amide and the contents cooled in ice bath and 1.87 g(10 mmol) of diepoxide 1 in 3 ml of THF was added to the above mixture and the contents were stirred for 18h while allowing the contents to warm up to room temperature. It was cooled back in an ice-bath and quenched with 20 ml (20 mmol) of 1M HCl in anhydrous ether. It was stirred for 5 minutes and then treated with 40 mL of 1M tetrabutylammonium fluoride in THF at 0° C. and then immediately warmed-up to room temperature and stirred for additional 2 hours. It was then cooled to 0° C. and then treated with 5.98 g (24 mmol) of N-(benzyloxycarbonyl)succinimide, stirred for 15 minutes, ice-bath was removed and the contents stirred at room temperature for 18h. It was concentrated and the residue dissolved in dichloromethane and the extract washed twice with water and once with brine. The residue after removal of dichloromethane was chromatographed (130 g silica gel, 2:3 followed by 1:1 ethyl acetate/hexane) to provide 2.44 g (yield 50%) of 8. 
     (2S,3R,4R,5S)-1,2:5,6-(N,N&#39;-Dibenzyloxycarbonyl)diimino-3,4-O-(isopropylidene)hexanediol 9 
     In a 500 mL Round Bottom Flask was placed 12.147 g (24.89 g mmol) of above compound, 15.669 g (59.7 mmol) of triphenylphosphine and dissolved in 150 mL of anhydrous THF. To the above mixture was added 9.40 mL (59.7 mmol) of diethyl azodicarboxylate and refluxed for 30 minutes under nitrogen. TLC indicated completion of the reaction(10:1:10 ethyl acetate/ethyl alcohol/hexane and 1:2 ethyl acetate/hexane). It was concentrated to a small volume and chromatographed (325 g silica gel column, 1:3 followed by 1:2 ethyl acetate/hexane as the eluting solvent) to provide 7.147 g (yield, 64%) of compound 9. 
     (2S,3R,4R,5S)-2,5-Di(N-((benzyloxy)carbonyl)diamino)-1,6-diphenyl-3,4-O-(isopropylidene)hexane 5 
     In a 50 mL R. B. Flask under nitrogen and in a glove . was placed 1.37 g (6.66 mmol) of cuprous bromide-dimethylsulfide complex and suspended in 2 mL ether and cooled to -20° C. and 6.66 mL (13.33 mmol) 2M solution of phenyllithium in 70:30 cyclohexane/ether was added dropwise to the mixture at -20° C. The mixture stirred at -20° C. for 30 minutes and then warmed to 0° C. 754 mg of above bisaziridine derivative in 2 mL ether and 6 mL THF was added to to the mixture at 0° C and stirred for 30 minutes at 0° C. TLC in 1:3 ethyl acetate/hexane indicated disappearance of the starting material. The excess reagent was quenched with saturated ammonium chloride, the mixture filtered, diluted with 20 mL of water and extracted with 2×25 mL of dichloromethane. The mixture was chromatgraphed (33 g silica gel column and 1:5 ethyl acetate/hexane as the eluting solvent) to provide 475 mg (47%) of 5. This intermediate is identical to compound 5 of Example 19B from which the final compound can be prepared according to the route provided by that Example. 
     EXAMPLES 20 AND 21 
     EXAMPLE 20 
     Synthesis of 2,5-(N-2-Pyridylacetyl-L-Ile)diamino-1,6-diphenyl-3,4-hexanediol ##STR79## 
     EXAMPLE 21 
     Synthesis of 2,5-(N-2-Pyridyl-L-Ile,N&#39;-2-pyridyl-D-Ile)diamino-1,6-diphenyl-3,4-hexanediol ##STR80## 
     Step 1: 2-Pyridylacetyl-Ile allyl ester ##STR81## 
     2-Pyridylacetyl-Ile allyl ester 
     A mixture of 1.717 g (5 mmol) pyridylacetic acid hydrochloride, 868 mg (5 mmol) of isoleucine allyl ester p-toluene sulfonate salt, molecular sieves 4° A type in dimethylformamide were stirred at 0° C. and 1.74 ml (10 mmol) of diisopropylethylamine was added to generate free amines. After stirring the contents at 0° C. for 15 minutes it was treated with 1.23 g (6 mmol) of dicyclohexylcarbodiimide and the contents were warmed up to room temperature. The mixture was stirred for 18 h, filtered and the residue purified (130 g, silica gel column chromatography using 1:1 EtOAc:hexane as the eluting solvent) to provide 712 mg (49% yield) of 2 pyridylacetyl-Ile allyl ester. This material showed  1  H NMR (CDCl 3 ): d 0.87 (d, 3H, J=6.9Hz), 0.894 (t, 3H, J=7.4Hz), 1.15 (m, 1H), 1.42 (m, 1H), 1.92 (m, 1H), 4.6 (m, 3H), 5.2-5.7 (m, 2H), 5.85 (m, 1H), 7.25 (m, 1H), 7.668 (d×t, 1H, J 1  =3.84, J=7 7Hz), 8.01 (bm, 1H), 8.577 (bd, 1H). 
     Step 2: 2-Pyridylacetyl-Ile ##STR82## 
     2-Pyridylacetyl-Ile 
     A mixture of 276 mg (0.95 mmol) of 2-pyridylacetyl 1- ester in 2 ml of 1,4-dioxane was stirred at room temperature and 1 ml of 1.0N sodium hydroxide was added in three equal portions after 15 minute intervals and the contents were stirred at room temperature for a total of 2 hours. The mixture was neutralized with addition of 1.0 ml (1 mmol) of 1N HCl. The mixture was diluted with 5 ml water and extracted with dichloromethane. The aqueous layer was saturated with solid sodium sulfate while stirring with 20 ml of chloroform. The combined organic extracts after removal of solvents provided 174 mg (74% yield) of 2-pyridylacetyl-Ile. This material showed  1  H NMR (CDCl 3 ): d 0.927 (d, 3H, J=6.8Hz), 0.927 (t, 3H, J=7.3Hz), 1.05-2.0 (bm, 3H), 3.872 (AB, 2H, JAB=13.8Hz), 4.539 (d×d, 1H, J 1  =5.21Hz, J 2  =8.22 Hz), 7.32 (d×d×d, 1H), 7.52 (bm, 1H), 7.785 (d×t, 1H, J 1  =7.71Hz, J 2  =1.8Hz), 8.53 (d×d×d, 1H). 
     Step 3: A solution of 101 mg (0.336 mmol) of 2,5-diamino-1,6-diphenyl-3,4-hexanediol and 168 mg (0.67 mmol) of 2-pyridylacetyl-Ile in 5 ml of dichloromethane was stirred with 25 mg of molecular sieves and 166 mg (0.8 mmol) of dicyclohexylcarbodiimide at room temperature for 18 h and filtered. The residue after removal of solvent was purified (33 silica gel column using 4%, 7% and 10% methanol in chloroform) to provide 46.5 mg (18%) of desired coupled product and 39.5 mg (15.3%) of a diastereomer to which was assigned structure 21 based on the spectral data. The compound of Example 20 had C-2 symmetry and showed  13  C NMR (CDCl 3 ): d 11.452, 15.643, 24.242, 35.975, 38.200, 44.912, 52.358, 58.680, 72.775, 122.273, 124.083, 126.171, 128.200, 129.299, 137.291, 138.056, 149.138, 149.138, 155.166, 169.740, 171.149. The compound of Example 21 had no C-2 symmetry and showed twice the number of  13  C NMR resonances (CDCl 3 ) d 11.454, 11.572, 14.380, 15.669, 24.234, 26.144, 35.891, 36.354, 38.102, 38.241, 44.837, 44.863, 52.504, 52.699, 57.485, 58.802, 72.897, 73.037, 122.197, 122.293, 124.065, 124.118, 126.140, 126.241, 128.220, 128.267, 128.381, 129.310, 137.209, 137.292, 138.121, 138.186, 149.167, 149.190, 155.205, 155.253, 169.673, 169.853, 171.319, 171.596. 
     EXAMPLE 23 
     Improved Method to Couple Aldehydes: Synthesis of Compound of Example 9 
     Bis(dimethylethyl) (2,3-dihydroxy-1,4-(phenylmethyl)-1,4-butanediyl)biscarbamate 
     Step A: Preparation of V(Cl 3  (THF) 3   
     V(Cl) 3  (Aldrich, 25 g) was added to 400 mL argon-sparged THF and the suspension heated to reflux under air-free conditions. After 24 hours, the mixture was cooled to room temperature and filtered under rigorously air-free conditions (schlenkware, glove bag or dry box), rinsed 4 times with 50 mL pentane, transferred to a schlenk tube and evacuated at 0.1 torr for 1 hour. 
     The tris-THF adduct is a bright salmon color, between pink and red. If caution is taken to avoid exposure to air, this material can be kept for months in a schlenk tube. On very brief exposure to air, however, the material turns to dusty orange, then tan, and must be discarded. 
     Step B: Preparation of An·Cu 
     Zinc-copper couple was prepared following the of Fieser and Fieser 3  (L. Fieser and M. Fieser, Reagents for Organic Synthesis, Volume I, pp. 1292-1293, Wiley, New York, 1967), except that filtration with schlenkware was used instead of decanting solvent. The use of a glovebag or drybox would be equally satisfactory. Also, solvents were sparged with argon for 30 minutes before use. A free-flowing black powder with few clumps was isolated. This material reduced V(III) to V(II) in dichloromethane within 10 minutes, whereas the use of commercial zinc dust or activated zinc required several hours and frequently did not provide the color change characteristic of complete reduction (see below). 
     Step C: Coupling Procedure 
     VCl 3  (THF) 3  (1.32 g, 3.53 mmol) was weighed into an argon-filled 35 mL RBF using a schlenk tube. Zinc-copper couple (138 mg, 2.12 mmol), weighed quickly in air, was added. The flask was fitted with a dropping funnel previously filled with argon and the two solids were stirred vigorously. Dry dichloromethane (8 mL) was added via the funnel, and the mixture was stirred for 10 minutes, by which time it had turned deep green with suspended black. 
     1,1-Dimethylethyl 1-formyl-3-phenylpropylcarbamate (1.00 g, 3.53 mmol), freshly prepared by Swern oxidation of the requisite alcohol, was added over 2-3 minutes in 4 mL dichloromethane. Stirring at room temperature and following by TLC (50% EtOAc/hexane) indicated complete loss of aldehyde starting material after 1.5 hours. 
     Notes: after addition of CH 2  Cl 2 , rigorous exclusion of air is necessary; before addition, exercise reasonable care. When exposed to even small amounts of air, the reduced material rapidly oxidizes to a deep wine-red. If this happens, discard the reaction and start over. 
     If the characteristic deep green color--best seen by holding a white sheet of paper behind the flask and looking at the gas-solvent interface--does not appear within 10-30 minutes, it is best to discard the reaction and re-prepare the reagents. 
     The reaction mixture was poured into a separatory funnel containing 50 mL dichloromethane and 100 mL 10% aqueous disodium tartrate (1N HCl can be used if acid-sensitive functionality is not present). After gentle shaking, separating, and washing the aqueous layer two times with 25 mL dichloromethane, the combined organic layers were washed with saturated sodium bicarbonate and dried with magnesium sulfate. Solvent was removed, the crude solid was taken up in minimum CHCl 3 , and 0.5 volumes hexane added. On sitting overnight, copious white crystals formed. Isolated 0.62 g (62%) product diol, mp 202°-204° C. Spectral data are consistent with the assigned structure. 
     EXAMPLES 24-98 
     Examples 24-98 were prepared by one of the methods described below. The method of preparation and physical data are shown in Table I. 
     Method 2C (Coupling of Aldehydes) 
     The improved coupling method, exemplified in Step C of Example 23, was used to prepare a number of the compounds shown in Table I. 
     Method 3 (Hydrogenation of Bis-N-CBZ-Diaminodiols) 
     The (bis-N-CBZ)-diaminodiols obtained either by vanadium coupling reaction or D-mannitol route can be hydrogenated and further elaborated at the amine residues. Table I shows examples prepared via this route. 
     Synthesis of Compound of Example 39 
     In a 200 ml R.B. Flask a suspension of 3.432 g (4.32 mmol) of the above intermediate in 25 ml ethanol and 25 ml methanol was stirred with a suspension of 343 mg 10% palladium on carbon under 1 atmospheric hydrogen pressure at room temperature for 18 hours. The suspension of starting material went into solution. The mixture was filtered through a celite pad and and the residue washed with ethanol. The filtrate and the washings were concentrated and the residue purified (130 g silica gel column using first 3% and finally 6% methanol in chloroform as the eluting solvent) to provide 1.848 g (81.3%) of 39 as a white solid. 
     Method 4 (Coupling of Diaminodiols) 
     The diamines obtained via Method 3 can be further elaborated by reaction with various electrophiles. Some preferred reaction conditions that provide active compounds are given below. Many other conditions and reagents can, of course, be employed. 
     4C: DICYCLOHEXYLCARBODIIMIDE (DCC) COUPLING 
     Dicyclohexylcarbodiimide (DCC) coupling in the presence 1-hydroxybenzotriazole hydrate was carried out according to standard procedure in peptide synthesis. A representative synthesis is described below. 
     Synthesis of Compound of Example 26 
     A solution of 101 mg (0.336 mmol) of 2,5-diamino-1,6-diphenyl-3,4-hexanediol, 108 mg (08 mmol) of 1-hydroxybenzotriazole and 168 mg (0.67 mmol) of 2-pyridylacetyl-Ile in 5 ml of dichloromethane was stirred with 25 mg of molecular sieves and 166 mg (0.8 mmol) of dicyclohexylcarbodiimide at room temperature for 18 h and filtered. The residue after removal of solvent was purified (33 g silica gel column using 4%, 7%, and 10% methanol in chloroform) to provide 86 mg (33% yield) of 26. The compound has C-2 symmetry and showed  13  C NMR (CDCl3): d 11.452, 15.643, 24.242, 35.975, 38.200, 44.912, 52.358, 58.680, 72.775, 122.273, 124.083, 126.171, 128.200, 129.299, 137.291, 138.056, 149.138, 149.138, 155.166, 169.740, 171. 
     4B: BOP COUPLING 
     BOP-Benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluorophosphate coupling was carried out according to the procedure by B. Castro et al. (Tetrahedron Lett., 1975, 14, 1219-1222). A representative synthesis is described below. 
     Synthesis of Compound of Example 81 
     BOC-Thiozolidine-4-carboxylic acid (0.94 g; 0.40 mmol) and [NH 2  CH(isopropyl)-C(O)--N--CH(OH)--]2 (0.100 g; 0.20 mmol) were dissolved in 10 ml of DMF, and BOP (0.177 g; 0.4 mmol) and triethylamine (0.056 ml; 0.40 mmol) were added in aliquots to maintain a pH of 7-8. The reaction was stirred for 18 hours. The residue after removal of solvent was purified by column chromatography on Sephadex LH-20 in methanol to provide 81 as amorphous solid (0.137 g). FAB/MS calculated for C 4  6H68N6O10S2 (928.44). Found 929.64 (M+H). 
     4C: CARBONYLDIIMIDAZOLE COUPLING 
     Synthesis of Compound of Example 88 
     N-MSOC-isoleucine (393 mg, 2.1 equivalents) was dissolved in THF; added carbonyldiimidazole (227 mg, 2.1 equivalents) at room temperature. Stirred under TLC showed loss of starting material. The reaction mixture was diluted with chloroform and 10% aqueous disodium L-tartrate was added. The layers were separated and the aqueous layer washed 1× with chloroform. Washed combined organic layers with saturated aqueous sodium bicarbonate and brine, dried with magnesium sulfate, filtered and removed solvent to obtain 540 mg white solid. Recrystallized from hot chloroform/hexane to obtain 343 mg fine white crystals; NMR consistent with 88. Melting point 222°-225° C. (dec). 
     4D: N-HYDROXYSUCCINIMIDE ESTER COUPLING 
     N-hydroxysuccinimide esters, available from Sigma Chemical Company or Advanced ChemTech, were used. 
     SYNTHESIS OF COMPOUND OF EXAMPLE 89 
     In a 300 ml R.B. flask a solution of 6.000 g (20mmol) of diamino diol in 60 ml of dimethylformamide was cooled in an ice bath. The mixture was treated with 14.070 g (44mmol) of Z-Isoleucine succinimide ester (available from Sigma Chemical Company or Advanced ChemTech) and stirred at room temperature for 18 hours. A precipitate had formed and was dissolved by adding one liter of chloroform. The mixture was then washed with water and the organic layer separated, dried over magnesium sulfate, filtered, and concentrated. The residue was dissolved in one liter of chloroform and the hexane added to precipitate out the desired product; however, after filtration the solid was contaminated with N-Hydroxysuccinimide. It was further purified (750 g silica gel column using first 1% followed by 1.5% methanol in chloroform as the eluting solvent) to provide 9.723 g (61.2%) of 89. 
     4E: p-NITROPHENYLESTER COUPLING 
     (1) With hydroxybenzotriazole hydrate: 
     Synthesis of Compound of Example 92 
     Diaminodiol of example 63 (250 mg, 1.0 equivalent), was dissolved in 5 mL DMF and N-CBZ-asparagine-p-nitrophenylester (373 mg, 2 equivalents, Sigma Chemical Company) and 1-hydroxybenzotriazole hydrate (135 mg, 2 equivalents) were added and the mixture was stirred overnight. The reaction mixture was triturated with THF for one hour, the solid was filtered off, washed with THF and chloroform, and collected to obtain 400 mg white crystals. NMR of the material is consistent with the structure. 
     (2) Without hydroxybenzotriazole hydrate: 
     Synthesis of Compound of Example 90 
     Diaminodiol of example 15 (200 mg, 1.0 equivalent) was dissolved in 5 mL DMF and N-CBZ-(d)-phenylalanine-p-nitrophenylester (332 mg, 2 equivalents, Sigma Chemical Company) was added and the mixture was stirred overnight. One volume of water was added, the solid was filtered off and washed with 1:1 water/DMF, then with water and finally with ether, and collected to obtain 320 mg white crystals. NMR showed the material to be consistent with the structure. 
     4F: CONDENSATION WITH ISOCYANATES 
     Synthesis of Compound of Example 67 
     In a 500 ml R.B. Flask, 2.500 g (4.75mmol) of the above intermediate in 100 ml dimethylformamide was cooled in an ice bath. The mixture was treated with 1.29 ml (10.45 mmol) of benzyl isocyanate via syringe and the mixture allowed to warm to room temperature where a precipitate started forming within 5 minutes. Within 30 minutes 100 ml more dimethylformamide was added to aid stirring. After stirring the mixture at room temperature a total of 2 hours the mixture was filtered and the solid washed with first dimethylformamide and then chloroform. The solid was transferred and dried to provide 3.230 g (85.7%) of 67 as a white solid. 
     4G: CONDENSATION WITH EPOXIDES 
     Epoxides can be condensed with diaminodiols. A representative example is given below. 
     SYNTHESIS OF COMPOUND OF EXAMPLE 71 
     The corresponding epoxide was prepared from 1-adamantyl bromomethyl ketone by reduction with sodium borohydride in absolute ethanol and treatment with potassium tert-butoxide. The adamantyl ethylene oxide was reacted with [NH 2  -Val-Phe[CH(OH)-]] 2  in methanol refluxing at 70 degrees Celsius overnight and chromatogrammed using Sephadex LH-20 column. (2 equivalents of oxide was used for every 1 equivalent of diol). 
     
         TABLE I
  ##STR83##
         MP      IC.sub.50 IC.sub.90 PHYS-     GAG CELLS ICAL METH-
 EXAMPLE R.sup.1
  -W R.sup.3 R.sup.4 mg/ml mg/ml DATA OD                             24
  ##STR84##
  2-butyl Ph 0.056   1 232-234 4A
  25
 ##STR85##
  2-butyl Ph 0.69  &gt;30 191- 194 4A
  27
 ##STR86##
  2-butyl Ph 0.177 &gt;30 207-213 4A
  28
 ##STR87##
  2-butyl
  ##STR88##
  0.155 2.4  (777.99) 4A
  29
 ##STR89##
  2-propyl Ph 0.041  0.95 248-252 4A
  30
 ##STR90##
  2-butyl Ph 0.082 2.8  (765.45) 4A
  31
 ##STR91##
  2-butyl Ph 0.03  2.9 256-260 4A
  32
 ##STR92##
  2-butyl Ph &gt;9 &gt;30 NMR 4A
  33
 ##STR93##
  2-methyl-propane Ph &gt;9 &gt;30 179-182 4A
  34
 ##STR94##
  2-butyl Ph &gt;9 &gt;30  (775.51) 4A
  35
 ##STR95##
  2-butyl Ph 0.019 0.3 247-250 4F
  36
 ##STR96##
  2-butyl Ph 0.085  0.95 NMR 4A
  37
 ##STR97##
  2-butyl Ph 0.024  0.15 NMR 4D
  38
 ##STR98##
   2-butyl Ph 0.055 &gt;30 NMR 4D  39 H.sub.2 N 2-butyl Ph 0.937  10 184-190
 4D;3
  40
 ##STR99##
  2-butyl Ph 0.03  2.2 228-232 4D
  41
 ##STR100##
  2-butyl Ph 0.21  2.8 NMR 4A
  42
 ##STR101##
  2-propyl Ph 0.025  0.05 216-221 4D
  43
 ##STR102##
  2-butyl Ph 0.055  0.11 263-266 4D
  44
 ##STR103##
  2-butyl Ph 0.028  0.09 200-206 4AwithoutHOBT
  45
 ##STR104##
  2-butyl Ph 1.24  8.9 141-144 4F
  46
 ##STR105##
  ##STR106##
  Ph 0.245 &gt;30 241-244 4E
  47
 ##STR107##
  ##STR108##
  Ph 1.12  &gt;30 264-267 4E
  48
 ##STR109##
  2-propyl
  ##STR110##
  &gt;9 &gt;30 160-164 1B;4D
  49
 ##STR111##
  2-propyl Ph 0.036 0.2 217-220 4A
  50
 ##STR112##
  2-propyl Ph 0.01  0.6 194-197 4F
  51
 ##STR113##
  2-butyl Ph 0.019 &gt;30 257-260 4A
  52
 ##STR114##
  2-butyl Ph 0.004 2.7 226-230 4F
  53
 ##STR115##
  ##STR116##
  Ph 0.2  2.6 NMR 4C
  54
 ##STR117##
  2-butyl
  ##STR118##
  3.4  5.0 130-134 2C
  55
 ##STR119##
  ##STR120##
  Ph &gt;9 &gt;30 &gt;250 4C
  56
 ##STR121##
  2-butyl Ph 0.03  2.2 228-232 4D
  57
 ##STR122##
  2-propyl Ph 0.044 8.9 &gt;250sintersat 220 4C
  58
 ##STR123##
  2-propyl Ph 0.31  &gt;30 198-199 4C
  59
 ##STR124##
  H.sub.2 CCHCH.sub.2  Ph 0.58  &gt;30 119-123 4C
  60
 ##STR125##
  CH.sub.3 SCH.sub.2 CH.sub.2  Ph 0.82  &gt;30 229-236 4C
  61
 ##STR126##
  2-propyl Ph 0.04  2.9 212-216 4D;3
  62
 ##STR127##
  2-propyl Ph 0.05  - &gt;245 4D  63 H.sub.2 N 2-propyl Ph   215-216 2C  64
  ##STR128##
  2-propyl Ph &gt;9 &gt;30  .sup. 65.sup.
  ##STR129##
  2-butyl Ph  &gt;10.4 &gt;30 147-151 4A  .sup.  66.sup.
  ##STR130##
  2-propyl Ph   235-238 4A
  67
 ##STR131##
  2-propyl Ph   288-292 4F
  68
 ##STR132##
  2-propyl
  ##STR133##
  &gt;9 &gt;30 190-192 4F
  69
 ##STR134##
  2-butyl Ph 0.065 -- 212-215 4D;3
  70
 ##STR135##
  2-propyl Ph    4E
  71
 ##STR136##
  2-propyl Ph &gt;11  &gt;30  (855.63) 4G
  72
 ##STR137##
  2-propyl Ph  &gt;9.2 &gt;30  (739.37) 4G
  73
 ##STR138##
  methyl Ph 1.62  &gt;30 (1071.6) 4B
  74
 ##STR139##
  2-propyl Ph 3.72    (937.55) 4B
  75
 ##STR140##
  2-propyl Ph 1.22   (NMR) 4B
  76
 ##STR141##
  2-propyl Ph 0.296 &gt;30  (937.71) 4B
  77
 ##STR142##
  2-propyl Ph 0.15    (737.55) 4B
  78
 ##STR143##
  2-propyl Ph 0.061   (869.67) 4B
  79
 ##STR144##
  2-propyl Ph 0.185   (669.60) 4B
  80
 ##STR145##
  2-propyl Ph  13 &gt;30  (929.64) 4B
  81
 ##STR146##
  2-propyl Ph 0.201 &gt;30  (729.59) 4B
  82
 ##STR147##
  2-propyl Ph 0.625 &gt;30  (993.81) 4B
  83
 ##STR148##
  2-propyl Ph 0.317 &gt;30  (725.66) 4B
  84
 ##STR149##
  CH.sub.3 Ph 0.151 &gt;30 236-237 2C
  85
 ##STR150##
  2-propyl Ph 0.007 &gt;30 229-233 4D;3
  86
 ##STR151##
  2-propyl Ph 0.3  &gt;30 162-168sintersat 94 4D;3
  87
 ##STR152##
  2-propyl Ph 3.3  &gt;30 M.P.&gt;245sinters120-130 4D;3
  88
 ##STR153##
  2-butyl Ph 0.039 8.5 222-225 4C
  89
 ##STR154##
  2-propyl Ph 0.04  &gt;30 M.P.&gt;245 4E
  90
 ##STR155##
  2-propyl Ph 0.67  30 M.P.&gt;245 4E
  91
 ##STR156##
  2-propyl Ph 0.042 0.2 239-241 4E
  92
 ##STR157##
  2-propyl Ph 0.08  &gt;30 &gt;245 4E
  93
 ##STR158##
  2-propyl Ph 0.099 1.0 237-238 4D
  94
 ##STR159##
  2-propyl
  ##STR160##
  0.123 &gt;30  (979.2) 2C
  95
 ##STR161##
  2-propyl Ph 12.5   &gt;30  209 4A
  96
 ##STR162##
  2-propyl Ph 0.100 0.7  274 4A
  97
 ##STR163##
  2-propyl Ph 0.250 0.9 168-170 4A
  98
 ##STR164##
  2-propyl Ph 0.050 0.3
 Physical Data indicates melting point range; parantheticals indicate
 parent ion of mass spec; NMR indicates compound gave satisfactory nmr.
 Method indicates method of preparation as described above under Examples
 24-98.
 .sup. indicates that the diol is protected as an acetonide.
 .sup.  indicates that this compound is a stereoisomer of the compound of
 Example 20.
 
    
     Tables II to XVI include additional preferred embodiments of the invention. However, these embodiments are not exemplified herein. 
     
                                           TABLE II                                
__________________________________________________________________________
 ##STR165##                                                               
EX                                                                        
NO.                                                                       
   R.sup.1    R.sup.2    R.sup.3   R.sup.4                                
__________________________________________________________________________
 99                                                                       
   CH.sub.3 C(O)                                                          
              CH.sub.3 C(O)                                               
                         PhCH.sub.2                                       
                                   PhCH.sub.2                             
100                                                                       
   CH.sub.3 C(O)                                                          
              CH.sub.3 C(O)                                               
                         4-HOC.sub.6 H.sub.4 CH.sub.2                     
                                   4-HOC.sub.6 H.sub.4 CH.sub.2           
101                                                                       
   CH.sub.3 C(O)                                                          
              CH.sub.3 C(O)                                               
                         3,4-dichloro-benzyl                              
                                   PhCH.sub.2                             
102                                                                       
   CH.sub.3 C(O)                                                          
              CH.sub.3 C(O)                                               
                         CH.sub.3 SCH.sub.2                               
                                   CH.sub.3 SCH.sub.2                     
103                                                                       
   CH.sub.3 C(O)                                                          
              CH.sub.3 C(O)                                               
                         CH.sub.3 SCH.sub.2                               
                                   PhCH.sub.2                             
104                                                                       
   CH.sub.3 C(O)                                                          
              CH.sub.3 C(O)                                               
                         (CH.sub.3).sub.2 CHCH.sub.2                      
                                   (CH.sub.3).sub.2 CHCH.sub. 2           
105                                                                       
   CH.sub.3 C(O)                                                          
              CH.sub.3 C(O)                                               
                         3-indolyl 3-indolyl                              
106                                                                       
   CH.sub.3 C(O)                                                          
              CH.sub.3 C(O)                                               
                         CH.sub.3 OC(O)(CH.sub.2).sub.5                   
                                   CH.sub.3 OC(O)(CH.sub.2).sub.5         
107                                                                       
   CH.sub.3 C(O)                                                          
              CH.sub.3 C(O)                                               
                         (CH.sub.3).sub.2 N(CH.sub.2).sub.3               
                                   (CH.sub.3).sub.2 N(CH.sub.2).sub.3     
108                                                                       
   CH.sub.3 (CH.sub.2)NHC(O)                                              
              CH.sub.3 (CH.sub.2)NHC(O)                                   
                         PhCH.sub.2                                       
                                   PhCH.sub.2                             
109                                                                       
   PhNHC(O)   PhNHC(O)   PhCH.sub.2                                       
                                   PhCH.sub.2                             
110                                                                       
   PhC(O)     PhC(O)     PhCH.sub.2                                       
                                   PhCH.sub.2                             
111                                                                       
   4-ClC.sub.6 H.sub.4 C(O)                                               
              4-ClC.sub.6 H.sub.4 C(O)                                    
                         PhCH.sub.2                                       
                                   PhCH.sub.2                             
112                                                                       
   3-MeC.sub.6 H.sub.4 C(O)                                               
              CH.sub.3 C(O)                                               
                         PhCH.sub.2                                       
                                   PhCH.sub.2                             
113                                                                       
   PhCH.sub.2 OC(O)                                                       
              PhCH.sub.2 OC(O)                                            
                         PhCH.sub.2                                       
                                   PhCH.sub.2                             
__________________________________________________________________________
 
    
     
                                           TABLE III                               
__________________________________________________________________________
 ##STR166##                                                               
Ex.                                                                       
No.                                                                       
   R.sup.7     R.sup.8     R.sup.3           R.sup.4                      
__________________________________________________________________________
114                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           PhCH.sub.2        PhCH.sub.2                   
115                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                            ##STR167##                                    
                                              ##STR168##                  
116                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           4-HOC.sub.6 H.sub.4 CH.sub.2                   
                                             4-HOC.sub.6 H.sub.4 CH.sub.2 
                                             1                            
117                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                            ##STR169##       PhCH.sub.2                   
118                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub. 3 C                                        
                           4-cyanobenzyl     4-cyanobenzyl                
119                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           2-nitrobenzyl     PhCH.sub.2                   
120                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           CF.sub.3 CH.sub.2 CF.sub.3 CH.sub.2            
121                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           CH.sub.3 (CH.sub.2).sub.6                      
                                             CH.sub.3 (CH.sub.2).sub.6    
122                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           (CH.sub.3).sub.2 CCHCH.sub.2                   
                                             (CH.sub.3).sub.2 CCHCH.sub.2 
                                             5                            
123                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           CH.sub.2 CHCH.sub.2                            
                                             CH.sub.2 CHCH.sub.2          
124                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           CH.sub.3 O.sub.2 C(CH.sub.2).sub.4             
                                             CH.sub.3 O.sub.2 C(CH.sub.2).
                                             sub.4                        
125                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           2-naphthyl        2-naphthyl                   
126                        122(naphthylmethyl)                            
                                             123(naphthylmethyl)          
127                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           1-naphthyl        1-naphthyl                   
128                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           cyclohexylmethyl  cyclohexylmethyl             
129                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           1-naphthyl        3,4-dichlorobenzyl           
130                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           2-(pyridylmethyl) 2-(pyridylmethyl)            
131                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           3-(pyridylmethyl) 3-(pyridylmethyl)            
132                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           4-(pyridylmethyl) 4-(pyridylmethyl)            
133                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           4-pyridazylmethyl)                             
                                             4-pyridazylmethyl)           
134                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           4-(imidazolylmethyl)                           
                                             4-(imidazolylmethyl)         
135                                                                       
   PhCH.sub.2  PhCH.sub.2  PhCH.sub.2        PhCH.sub.2                   
136                                                                       
   PhCH.sub.2  PhCH.sub.2  4-HOC.sub.6 H.sub.4 CH.sub.2                   
                                             4-HOC.sub.6 H.sub.4 CH.sub.2 
137                                                                       
   PhCH.sub.2  PhCH.sub.2  CH.sub.3 SCH.sub.2                             
                                             CH.sub.3 SCH.sub.2           
138                                                                       
   PhCH.sub.2  PhCH.sub.2  2-thiophenyl      2-thiophenyl                 
139                                                                       
   PhCH.sub.2  PhCH.sub.2  HS(CH.sub.2).sub.4                             
                                             HS(CH.sub.2).sub.4           
140                                                                       
   PhCH.sub.2  PhCH.sub.2  4-(benzyloxy)benzyl                            
                                             4-(benzyloxy)benzyl          
141                                                                       
   PhCH.sub.2  PhCH.sub.2  3-(methane-sulfonyl)benzyl                     
                                             3-(methane-sulfonyl)benzyl   
142                                                                       
   PhCH.sub.2  PhCH.sub.2  3,4-methylene-dioxybenzyl                      
                                             3,4-methylene-dioxybenzyl    
143                                                                       
   PhCH.sub.2  PhCH.sub.2                                                 
                            ##STR170##                                    
                                              ##STR171##                  
144                                                                       
   PhCH.sub.2  PhCH.sub.2  CH.sub.3 NHC(O)CH.sub.2 CH.sub.2               
                                              ##STR172##                  
145                                                                       
   PhCH.sub.2  PhCH.sub. 2 cyclohexylmethyl  cyclohexylmethyl             
146                                                                       
   PhCH.sub.2  PhCH.sub.2  cyclopropylmethyl cyclopropylmethyl            
147                                                                       
   PhCH.sub.2  PhCH.sub.2                                                 
                            ##STR173##                                    
                                              ##STR174##                  
148                                                                       
   (4-CF.sub.3)C.sub.6 H.sub.4 CH.sub.2                                   
               (4-CF.sub.3)C.sub.6 H.sub.4 CH.sub.2                       
                           PhCH.sub.2        PhCH.sub.2                   
149                                                                       
   2-C.sub.5 H.sub.5 NCH.sub.2                                            
               2-C.sub.5 H.sub.5 NCH.sub.2                                
                           PhCH.sub.2        PhCH.sub.2                   
150                                                                       
   4-[(CH.sub.3).sub.3 C]C.sub.6 H.sub.4 CH.sub.2                         
               4-[(CH.sub.3).sub.3 C]C.sub.6 H.sub.4 CH.sub.2             
                           PhCH.sub.2        PhCH.sub.2                   
151                                                                       
   (CH.sub.3).sub.2 CCHCH.sub.2                                           
               (CH.sub.3).sub.2 CCHCH.sub.2                               
                           PhCH.sub.2        PhCH.sub.2                   
152                                                                       
   4-[SO.sub.2 NH.sub.2 ]C.sub.6 H.sub.4 CH.sub.2                         
               4-[SO.sub.2 NH.sub.2 ]C.sub.6 H.sub.4 CH.sub.2             
                           PhCH.sub.2        PhCH.sub.2                   
153                                                                       
   PhCH.sub.2  PhCH.sub.2  CH.sub.3 CH.sub.2 CH.sub.2                     
                                             CH.sub.3 CH.sub.2 CH.sub.2   
154                                                                       
   (CH.sub.3).sub.3 C                                                     
               (CH.sub.3).sub.3 C                                         
                           CH.sub.3 CH.sub.2 CH.sub.2                     
                                             CH.sub.3 CH.sub.2 CH.sub.2   
155                                                                       
   4-[ SO.sub.2 NH.sub.2 ]C.sub.6 H.sub.4 CH.sub.2                        
               4-[SO.sub.2 NH.sub.2 ]C.sub.6 H.sub.4 CH.sub.2             
                           CH.sub.3 CH.sub.2 CH.sub.2                     
                                             CH.sub.3 CH.sub.2 CH.sub.2   
__________________________________________________________________________
 
    
     
                                           TABLE IV                                
__________________________________________________________________________
 ##STR175##                                                               
EX.                                                                       
NO.                                                                       
   R.sup.7 X.sup.1  R.sup.8 X.sup.2                                       
__________________________________________________________________________
156                                                                       
   PhC(O)           PhC(O)                                                
157                                                                       
   (CH.sub.3).sub.3 CC(O)                                                 
                    (CH.sub.3).sub.3 CC(O)                                
158                                                                       
   2-pyridylcarbonyl                                                      
                    2-pyridylcarbonyl                                     
159                                                                       
   HValVal          ValValOH                                              
160                                                                       
   HSerAlaAla       ValValOH                                              
161                                                                       
   BocSerAlaAla     ValValOMe                                             
162                                                                       
   HAlaAla          ValValOMe                                             
163                                                                       
   HValSerGlnAsn    IleValOH                                              
164                                                                       
   AcLeuVal         ValLeuOMe                                             
165                                                                       
   AcLysVal         ValLysAc                                              
166                                                                       
   ValBocValVal     ArgValOMe                                             
167                                                                       
   HArgGlyVal       ValGlyArgOH                                           
168                                                                       
   cyclohexylcarbonyl                                                     
                    cyclohexylcarbonyl                                    
169                                                                       
   PhC(O)           CH.sub.3 (CO)                                         
170                                                                       
   PhNHC(O)         PhNH(CO)                                              
171                                                                       
   PhCH.sub.2 NHC(O)                                                      
                    PhCH.sub.2 NHC(O)                                     
172                                                                       
   4-BrC.sub.6 H.sub.4 CH(CH.sub.3)NHC(O)                                 
                    4-BrC.sub.6 H.sub.4 CH(CH.sub.3)NHC(O)                
173                                                                       
   Ph(CS)           Ph(C S)                                               
174                                                                       
   CH.sub.3         CH.sub.3                                              
175                                                                       
   PhSO.sub.2       PhSO.sub.2                                            
176                                                                       
   2-pyridylmethylaminocarbonyl                                           
                    2-pyridylmethylaminocarbonyl                          
177                                                                       
   2-pyridylacetyl-Asn                                                    
                    2-pyridylacetyl-Asn                                   
178                                                                       
   2-pyridylacetyl-Val                                                    
                    2-pyridylacetyl-Asn                                   
179                                                                       
   2-pyridylacetyl-Leu                                                    
                    2-pyridylacetyl-Leu                                   
180                                                                       
   2-pyridylacetyl-Gln                                                    
                    2-pyridylacetyl-Gln                                   
181                                                                       
   phenylacetyl-Ile phenylacetyl-Ile                                      
182                                                                       
   phenylacetyl-Asn phenylacetyl-Asn                                      
183                                                                       
   phenylacetyl-Gln phenylacetyl-Gln                                      
184                                                                       
   phenylacetyl-Val phenylacetyl-Val                                      
185                                                                       
   phenylacetyl-Leu phenylacetyl-Leu                                      
186                                                                       
   quinoline-2-carbonyl-Asn                                               
                    quinoline-2-carbonyl-Asn                              
187                                                                       
   qunioline-2-carbonyl-Gln                                               
                    qunioline-2-carbonyl-Ile                              
188                                                                       
   quinoline-2-carbonyl-Ile                                               
                    quinoline-2-carbonyl-Ile                              
189                                                                       
   quinoline-2-carbonyl-Leu                                               
                    quinoline-2-carbonyl-Val                              
190                                                                       
   2-pipecolinyl-Ile                                                      
                    2-pipecolinyl-Asn                                     
191                                                                       
   2-pipecolinyl-Asn                                                      
                    2-pipecolinyl-Asn                                     
192                                                                       
   2-pipecolinyl-Ile                                                      
                    2-pipecolinyl-Ile                                     
193                                                                       
   t-butylacetyl-Asn                                                      
                    t-butylacetyl-Asn                                     
194                                                                       
   t-butylacetyl-Asn                                                      
                    t-butylacetyl-Ile                                     
195                                                                       
   t-butylacetyl-Ile                                                      
                    t-butylacetyl-Ile                                     
196                                                                       
   isoquinoline-3-formyl-Asn                                              
                    isoquinoline-3-formyl-Asn                             
197                                                                       
   isoquinoline-3-formyl-Asn                                              
                    isoquinoline-3-formyl-Ile                             
198                                                                       
   isoquinoline-3-formyl-Ile                                              
                    isoquinoline-3-formyl-Ile                             
199                                                                       
   2-naphthoyl-Asn  2-naphthoyl-Asn                                       
200                                                                       
   2-naphthoyl-Gln  2-naphthoyl-Ile                                       
201                                                                       
   2-naphthoyl-Ile  2-naphthoyl-Ile                                       
202                                                                       
   2-naphthoyl-Ile  2-naphthoyl-Asn                                       
203                                                                       
   2-naphthoyl-Val  2-naphthoyl-Ile                                       
204                                                                       
   cyclohexylacetyl-Asn                                                   
                    cyclohexylacetyl-Asn                                  
205                                                                       
   cyclohexylacetyl-Ile                                                   
                    cyclohexylacetyl-Ile                                  
206                                                                       
   cyclohexylacetyl-Asn                                                   
                    cyclohexylacetyl-Ile                                  
__________________________________________________________________________
 
    
     
                                           TABLE V                                 
__________________________________________________________________________
 ##STR176##                                                               
Ex.                                                                       
No.                                                                       
   R.sup.1          W         R.sup.3       R.sup.4         R.sup.18      
__________________________________________________________________________
207                                                                       
   2-pyridylmethyl  A(O)      2-propyl      benzyl          H             
208                                                                       
   2-pyridylmethyl  B(O)      2-butyl       4-imidazolylmethyl            
                                                            H             
209                                                                       
   benzyl           C(O)      2-butyl       cyclohexylmethyl              
                                                            H             
210                                                                       
   benzyl           D(O)      2-propyl      benzyl          H             
211                                                                       
   benzyl           E(O)      2-propyl      benzyl          CH.sub.3      
213                                                                       
   benzyl           F(O)      benzyl        benzyl          H             
214                                                                       
   n-propyl         G(O)      2-propyl      benzyl          H             
215                                                                       
   naphthyl         H(O)      2-propyl      benzyl          H             
216                                                                       
   phenyl           I(O)      2-propyl      benzyl          H             
217                                                                       
   thiophenyl       J(O)      2-propyl      benzyl          H             
218                                                                       
   trifluoromethyl  K(O)      2-propyl      benyzl          H             
219                                                                       
   benzyl           L(O)CH.sub.2                                          
                              2-propyl      benzyl          H             
220                                                                       
   2-pyridylmethyl  M(O)NH    2-butyl       benzyl          H             
221                                                                       
   benzyl           N(O)NH    2-butyl       benzyl          H             
222                                                                       
   benzyl           O(O)NH    2-butyl       benzyl          CH.sub.3      
223                                                                       
   benzyl           P(O)NH    2-butyl       Q(-trifluoromethylbenzyl      
                                                            H             
224                                                                       
   benzyl           R(O)NH    cyclobutyl    benzyl          H             
225                                                                       
   benzyl           S(O)NH    cyclobutylmethyl                            
                                            benzyl          H             
226                                                                       
   methyl           T(O)NH    2-butyl       benzyl          H             
227                                                                       
   phenylethyl      U(O)NH    2-butyl       benzyl          H             
228                                                                       
   benzyl           V(O)NHNH  2-propyl      benzyl          H             
229                                                                       
   benzyl           W(O)O     2-propyl      benzyl          H             
230                                                                       
   benzyl           X(S)      2-propyl      benzyl          H             
231                                                                       
   benzyl           Y(S)NH    2-propyl      benzyl          H             
232                                                                       
   benzyl           C(Cl)N    2-propyl      benzyl          H             
233                                                                       
   2-pyridylmethyl  C(NHMe)N  2-propyl      benzyl          H             
234                                                                       
   3-methylpropyl   C(NHMe)N  2-propyl      benzyl          H             
235                                                                       
   benzyl           C(NHMe)N  2-propyl      benzyl          H             
236                                                                       
   benzyl           C(NHMe)N  2-propyl      benzyl          CH.sub.3      
237                                                                       
   benzyl           C(NHMe)N  2-propyl      Z((HCF.sub.2 O)C.sub.6        
                                            H4CH.sub.2                    
238                                                                       
   2-pyridylethyl   C(OCH.sub.2 CH.sub.3)N                                
                              2-propyl      benzyl          H             
239                                                                       
   3-naphthylmethyl C(OCH.sub.2 CH.sub.3)N                                
                              2-propyl      benzyl          H             
240                                                                       
   AA(-t-butylbenzyl                                                      
                    C(OCH.sub.2 CH.sub.3)N                                
                              2-propyl      benzyl          H             
241                                                                       
   benzyl           C(OCH.sub.2 CH.sub.3)N                                
                              2-propyl      benzyl          H             
242                                                                       
   benzyl           C(OCH.sub.2 CH.sub.3)N                                
                              2-propyl      BB(-ytrifluoromethylbenzyl    
                                                            H             
243                                                                       
   benzyl           C(OCH.sub.2 CH.sub.3)N                                
                              2-propyl      CC(-chlorobenzyl              
                                                            H             
244                                                                       
   benzyl           C(OCH.sub.2 CH.sub.3)N                                
                              2-propyl      cyclohexylmethyl              
                                                            H             
245                                                                       
   benzyl           C(OCH.sub.2 CH.sub.3)N                                
                              cyclobutyl    benzyl          H             
246                                                                       
   benzyl           C(OCH.sub.2 CH.sub.3)N                                
                              cyclobutylmethyl                            
                                            benzyl          H             
247                                                                       
   benzyl           C(OCH.sub.2 CH.sub.3)N                                
                              cyclopropyl   benzyl          H             
248                                                                       
   benzyl           C(OCH.sub.3)N                                         
                              2-propyl      benzyl          H             
249                                                                       
   benzyl           CH.sub.2 OCH.sub.2                                    
                              2-propyl      benzyl          H             
250                                                                       
   benzyl           CH.sub.2 CH.sub.2                                     
                              2-propyl      benzyl          H             
251                                                                       
   benzyl           CH.sub.2 CHOH                                         
                              2-propyl      benzyl          H             
252                                                                       
   benzyl           CH.sub.2 O                                            
                              2-propyl      benzyl          H             
253                                                                       
   benzyl           CH.sub.2 OH                                           
                              2-propyl      benzyl          H             
254                                                                       
   benzyl           CHCH      2-propyl      benzyl          H             
255                                                                       
   benzyl           CHOHCH.sub.2                                          
                              2-propyl      benzyl          H             
256                                                                       
   benzyl           CHOHCHOH  2-propyl      benzyl          H             
257                                                                       
   benzyl           HNC(S)NH  2-propyl      benzyl          H             
258                                                                       
   benzyl           HNSO.sub.2                                            
                              2-butyl       benzyl          H             
259                                                                       
   benzyl           HNSO.sub.2 NH                                         
                              2-butyl       benzyl          H             
260                                                                       
   benzyl           DD(       2-propyl      benzyl          H             
261                                                                       
   benzyl           NHNH      2-propyl      benzyl          H             
262                                                                       
   (CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 )                        
                    NHC(O)NH  2-butyl       benzyl          H             
263                                                                       
   (CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 )                                
                    NHC(O)NH  2-butyl       benzyl          H             
264                                                                       
   2-hydroxy-3,3-dimethylpropyl                                           
                    NHC(O)NH  2-butyl       benzyl          H             
265                                                                       
   2-hydroxy-3,3-dimethylpropyl                                           
                    NHC(O)NH  2-butyl       benzyl          CH.sub.3      
266                                                                       
   2-hydroxyindanylmethyl                                                 
                    NHC( O)NH 2-butyl       benzyl          H             
267                                                                       
   3,5-dimethoxyphenyl                                                    
                    NHC(O)NH  2-butyl       benzyl          H             
268                                                                       
   3-hydroxy-n-propyl                                                     
                    NHC(O)NH  2-butyl       benzyl          H             
269                                                                       
   270-nitrobenzyl  NHC(O)NH  2-butyl       benzyl          H             
271                                                                       
   4-benzyloxyphenylmethyl                                                
                    NHC(O)NH  2-butyl       benzyl          H             
272                                                                       
   4-cyano-n-butyl  NHC(O)NH  2-butyl       benzyl          H             
273                                                                       
   4-phenoxyphenylmethyl                                                  
                    NHC(O)NH  2-butyl       benzyl          H             
274                                                                       
   4-t-butylphenylmethyl                                                  
                    NHC(O)NH  2-butyl       benzyl          H             
275                                                                       
   adamantyl        NHC(O)NH  2-butyl       benzyl          H             
276                                                                       
   benzyl           NHC(O)NH  2-butyl       benzyl          H             
277                                                                       
   benzyl           NHC(O)NH  2-butyl       benzyl          CH.sub.3      
278                                                                       
   benzyl           NHC(O)NH  2-propyl      benzyl          H             
279                                                                       
   benzyl           NHC(O)NH  2-propyl      2-naphthylmethyl              
                                                            H             
280                                                                       
   benzyl           NHC(O)NH  2-propyl      3-naphthylmethyl              
                                                            H             
281                                                                       
   benzyl           NHC(O)NH  2-propyl      1-adamantylmethul             
                                                            H             
282                                                                       
   benzyl           NHC(O)NH  2-propyl      FF(-hydroxybenzyl             
                                                            H             
283                                                                       
   benzyl           NHC(O)NH  2-propyl      2-imidazolylethyl             
                                                            H             
284                                                                       
   benzyl           NHC(O)NH  2-propyl      4-pyridinylmethyl             
                                                            H             
285                                                                       
   benzyl           NHC(O)NH  2-propyl      4-bromophenyl   H             
286                                                                       
   benzyl           NHC(O)NH  2-propyl      cycloheptylmethyl             
                                                            H             
287                                                                       
   benzyl           NHC(O)NH  2-propyl      2-thiophenylmethyl            
                                                            H             
288                                                                       
   benzyl           NHC(O)NH  2-propyl      3-pyrrazolylmethyl            
                                                            H             
289                                                                       
   benzyl           NHC(O)NH  2-propyl      GG((trifluoromethane-         
                                                            H             
                                            sulfonyl)propyl               
290                                                                       
   benzyl           NHC(O)NH  2-propyl      HH((1-          H             
                                            methyl)piperidinylmethyl      
291                                                                       
   benzyl           NHC(O)NH  2-thiazolylmethyl                           
                                            benzyl          H             
292                                                                       
   benzyl           NHC(O)NH  benzyl        benzyl          H             
293                                                                       
   benzyl           NHC(O)NH  CH.sub.2 CF3  benzyl          H             
294                                                                       
   benzyl           NHC(O)NH  CH.sub.2 CH.sub.2 C(O)NH2                   
                                            benzyl          H             
295                                                                       
   benzyl           NHC(O)NH  CH.sub.2 CH.sub.2 OH                        
                                            benzyl          H             
296                                                                       
   benzyl           NHC(O)NH  CH.sub.2 CHOHCH.sub.3                       
                                            benzyl          H             
297                                                                       
   benzyl           NHC(O)NH  cyclobutyl    benzyl          H             
298                                                                       
   benzyl           NHC(O)NH  cyclobutyl    benzyl          CH.sub.3      
299                                                                       
   benzyl           NHC(O)NH  cyclobutylmethyl                            
                                            benzyl          H             
300                                                                       
   benzyl           NHC(O)NH  cyclopentylmethyl                           
                                            benzyl          H             
301                                                                       
   benzyl           NHC(O)NH  cyclopropyl   benzyl          H             
302                                                                       
   benzyl           NHC(O)NH  cyclopropylmethyl                           
                                            benzyl          H             
303                                                                       
   cis-2-decahydronaphthylmethyl                                          
                    NHC(O)NH  2-butyl       benzyl          H             
304                                                                       
   cis-2-decahydronaphthylmethyl                                          
                    NHC(O)NH  2-butyl       benzyl          CH.sub.3      
305                                                                       
   benzyl           O         2-propyl      benzyl          H             
306                                                                       
   (CH.sub.2 CH.sub.2 CH)CH.sub.2 CH.sub.2                                
                    OC(O)NH   2-butyl       benzyl          H             
307                                                                       
   1-piperidylethyl OC(O)NH   2-butyl       benzyl          H             
308                                                                       
   2-benzimidazolylmethyl                                                 
                    OC(O)NH   2-butyl       benzyl          H             
309                                                                       
   2-naphthylmethyl OC(O)NH   2-butyl       benzyl          H             
310                                                                       
   2-pyridylmethyl  OC(O)NH   2-butyl       benzyl          H             
311                                                                       
   2-quinazolinylmethyl                                                   
                    OC(O)NH   2-butyl       benzyl          H             
312                                                                       
   3,4-methylene-   OC(O)NH   2-butyl       benzyl          H             
   dioxyphenylmethyl                                                      
313                                                                       
   3-chlorobenzyl   OC(O)NH   2-butyl       benzyl          H             
314                                                                       
   3-phenylpropyl   OC(O)NH   2-butyl       benyzl          H             
315                                                                       
   II(-acetamidobenzyl                                                    
                    OC(O)NH   2-butyl       benzyl          H             
316                                                                       
   4-imidazolylmethyl                                                     
                    OC(O)NH   2-butyl       benzyl          H             
317                                                                       
   4-methanesulfonylbenzyl                                                
                    OC(O)NH   2-butyl       benzyl          H             
318                                                                       
   4-methoxybenzyl  OC(O)NH   2-butyl       benzyl          H             
319                                                                       
   4-pyridylmethyl  OC(O)NH   2-butyl       benzyl          H             
320                                                                       
   4-trifluoromethylbenzyl                                                
                    OC(O)NH   2-butyl       benzyl          H             
321                                                                       
   9-fluorenylmethyl                                                      
                    OC(O)NH   2-butyl       benzyl          H             
322                                                                       
   adamantylmethyl  OC(O)NH   2-butyl       benzyl          H             
323                                                                       
   benzyl           OC(O)NH   1-methoxy-2-propyl                          
                                            benzyl          H             
324                                                                       
   benzyl           OC(O)NH   325-hydroxycyclo-                           
                                            benzyl          H             
                              pentylmethyl                                
326                                                                       
   benzyl           OC(O)NH   2,2,2-tri-chloroethyl                       
                                            benzyl          H             
327                                                                       
   benzyl           OC(O)NH   2,2,2-tri-fluoroethyl                       
                                            benzyl          H             
328                                                                       
   benzyl           OC(O)NH   2-butyl       benzyl          H             
329                                                                       
   benzyl           OC(O)NH   2-propyl      benzyl          H             
330                                                                       
   benzyl           OC(O)NH   2-propyl      benzyl          CH.sub.3      
331                                                                       
   benzyl           OC(O)NH   2-propyl      3-naphthylmethyl              
                                                            H             
332                                                                       
   benzyl           OC(O)NH   2-propyl      KK(-phenoxybenzyl             
                                                            H             
333                                                                       
   benzyl           OC(O)NH   2-propyl      LL(-benzyloxybenzyl           
                                                            H             
334                                                                       
   benzyl           OC(O)NH   2-propyl      MM(-(5-tetrazolyl)benzyl      
                                                            H             
335                                                                       
   benzyl           OC(O)NH   2-propyl      NN(,5&#39;-bis(trifluore-         
                                                            H             
                                            methyl)benzyl                 
336                                                                       
   benzyl           OC(O)NH   2-propyl      OO(-trifluoromethylbenzyl     
                                                            H             
337                                                                       
   benzyl           OC(O)NH   2-propyl      2-phenylethyl   H             
338                                                                       
   benzyl           OC(O)NH   2-propyl      2-benzimidazolylmethyl        
                                                            H             
339                                                                       
   benzyl           OC(O)NH   2-propyl      PP((4-chlorophenyl)ethyl      
                                                            H             
340                                                                       
   benzyl           OC(O)NH   2-propyl      2-decahydronaphthylmethyl     
                                                            H             
341                                                                       
   benzyl           OC(O)NH   2-propyl      QQ((3,4-methylene-            
                                                            H             
                                            dioxyphenyl)ethyl             
342                                                                       
   benzyl           OC(O)NH   RR((dimethylamino)-                         
                                            benzyl          H             
                              1-propyl                                    
343                                                                       
   benzyl           OC(O)NH   benzyl        benzyl          H             
344                                                                       
   benzyl           OC(O)NH   CH.sub.2 NHC(O)NHCH.sub.3                   
                                            4-pyridylmethyl H             
345                                                                       
   benzyl           OC(O)NH   CH.sub. 2 NHSO.sub.2 CH.sub.3               
                                            benzyl          H             
346                                                                       
   benzyl           OC(O)NH   cyclobutyl    benzyl          H             
347                                                                       
   benzyl           OC(O)NH   cyclobutylmethyl                            
                                            benzyl          H             
348                                                                       
   benzyl           OC(O)NH   cyclopropyl   2-pyridylmethyl H             
349                                                                       
   benzyl           OC(O)NH   cyclopropylmethyl                           
                                            benzyl          H             
350                                                                       
   benzyl           OC(O)NH   methyl        benzyl          H             
351                                                                       
   CH.sub.3 SO.sub.2 CH.sub.2 CH.sub.2                                    
                    OC(O)NH   2-butyl       benzyl          H             
352                                                                       
   cyclopentylethyl OC(O)NH   2-butyl       2-pyridylmethyl H             
353                                                                       
   F.sub.2 HCOC.sub.6 H4CH.sub.2                                          
                    OC(O)NH   2-butyl       3-pyridylmethyl H             
354                                                                       
   N,N-dimethylamino-3-propyl                                             
                    OC(O)NH   2-butyl       benzyl          H             
355                                                                       
   benzyl           OCH.sub.2 2-propyl      benzyl          H             
356                                                                       
   benzyl           OP(O)(OMe)O                                           
                              2-propyl      2-pyridylmethyl H             
357                                                                       
   benzyl           SO.sub.2  2-propyl      benzyl          H             
358                                                                       
   2,4-difluorophenyl                                                     
                    SO.sub.2 NH                                           
                              2-butyl       2-pyridylmethyl H             
359                                                                       
   SS(-methylphenyl SO.sub.2 NH                                           
                              2-butyl       benzyl          H             
360                                                                       
   benzyl           SO.sub.2 NH                                           
                              TT((methylamino)ethyl                       
                                            benzyl          H             
361                                                                       
   benzyl           SO.sub.2 NH                                           
                              2-furanylmethyl                             
                                            benzyl          H             
362                                                                       
   benzyl           SO.sub.2 NH                                           
                              2-propyl      benzyl          H             
363                                                                       
   benzyl           SO.sub.2 NH                                           
                              2-propyl      benzyl          Et            
364                                                                       
   benzyl           SO.sub.2 NH                                           
                              2-propyl      UU(-trifluoromethylbenzyl     
                                                            H             
365                                                                       
   benzyl           SO.sub.2 NH                                           
                              2-propyl      VV(,4&#39;-difluorobenzyl         
                                                            H             
366                                                                       
   benzyl           SO.sub.2 NH                                           
                              2-propyl      3-phenylpropyl  H             
367                                                                       
   benzyl           SO.sub.2 NH                                           
                              2-propyl      1-pyrrolylethyl H             
368                                                                       
   benzyl           SO.sub.2 NH                                           
                              2-propyl      WW((4-chlorophenyl)ethyl      
                                                            H             
369                                                                       
   benzyl           SO.sub.2 NH                                           
                              2-propyl      1-phenylethyl   H             
370                                                                       
   benzyl           SO.sub.2 NH                                           
                              3-hydroxy-1-propyl                          
                                            1-phenylethyl   H             
371                                                                       
   benzyl           SO.sub.2 NH                                           
                              cyclobutyl    benzyl          H             
372                                                                       
   benzyl           SO.sub.2 NH                                           
                              cyclopropyl   benzyl          H             
373                                                                       
   benzyl           SO.sub.2 NH                                           
                              methylthiomethyl                            
                                            1-phenylethyl   H             
374                                                                       
   cyclohexylethyl  SO.sub.2 NH                                           
                              2-butyl       2-pyridylmethyl H             
375                                                                       
   nonafluorobutyl  SO.sub.2 NH                                           
                              2-butyl       benzyl          H             
376                                                                       
   phenyl           SO.sub.2 NH                                           
                              2-butyl       2-pyridylmethyl H             
377                                                                       
   trifluoromethyl  SO.sub.2 NH                                           
                              2-butyl       benzyl          H             
378                                                                       
   2,4-difluorophenyl                                                     
                    SO.sub.2 NHC(O)NH                                     
                              2-butyl       benzyl          H             
379                                                                       
   XX(-methylphenyl SO.sub.2 NHC(O)NH                                     
                              YY((dimethyl- 3-pyridylmethyl H             
                              amino)ethyl                                 
380                                                                       
   ZZ(-methylphenyl SO.sub.2 NHC(O)NH                                     
                              2-butyl       benzyl          H             
381                                                                       
   AAA(-methylphenyl                                                      
                    SO.sub.2 NHC(O)NH                                     
                              2-butyl       4-pyridylmethyl H             
382                                                                       
   BBB(-methylphenyl                                                      
                    SO.sub.2 NHC(O)NH                                     
                              benzyl        benzyl          H             
383                                                                       
   CCC(-methylphenyl                                                      
                    SO.sub.2 NHC(O)NH                                     
                              CH.sub.2 CH.sub.2 OH                        
                                            benzyl          H             
384                                                                       
   DDD(-methylphenyl                                                      
                    SO.sub.2 NHC(O)NH                                     
                              cyclobutyl    benzyl          H             
385                                                                       
   EEE(-methylphenyl                                                      
                    SO.sub.2 NHC(O)NH                                     
                              cyclohexylmethyl                            
                                            4-pyridylmethyl H             
386                                                                       
   FFF(-methylphenyl                                                      
                    SO.sub.2 NHC(O)NH                                     
                              cyclopropyl   benzyl          H             
387                                                                       
   benzyl           SO.sub.2 NHC(O)NH                                     
                              2-butyl       benzyl          H             
388                                                                       
   cyclohexylethyl  SO.sub.2 NHC(O)NH                                     
                              2-butyl       2-pyridylmethyl H             
389                                                                       
   methyl           SO.sub.2 NHC(O)NH                                     
                              2-butyl       benzyl          H             
390                                                                       
   nonafluorobutyl  SO.sub.2 NHC(O)NH                                     
                              2-butyl       benzyl          H             
391                                                                       
   phenyl           SO.sub.2 NHC(O)NH                                     
                              2-butyl       3-pyridylmethyl H             
392                                                                       
   phenyl           SO.sub.2 NHC(O)NH                                     
                              2-butyl       benzyl          H             
393                                                                       
   phenyl           SO.sub.2 NHC(O)NH                                     
                              2-butyl       GGG(-chlorobenzyl             
                                                            H             
394                                                                       
   phenyl           SO.sub.2 NHC(O)NH                                     
                              2-butyl       3-naphthylmethyl              
                                                            H             
395                                                                       
   phenyl           SO.sub.2 NHC(O)NH                                     
                              2-butyl       HHH((4-fluorophenyl)ethyl     
                                                            H             
396                                                                       
   phenyl           SO.sub.2 NHC(O)NH                                     
                              2-butyl       2-phenylethyl   H             
397                                                                       
   phenyl           SO.sub.2 NHC(O)NH                                     
                              2-butyl       III(-carbomethoxybenzyl       
                                                            H             
398                                                                       
   phenyl           SO.sub.2 NHC(O)NH                                     
                              2-butyl       2-pyridylmethyl CH.sub.3      
399                                                                       
   phenyl           SO.sub.2 NHC(O)NH                                     
                              cyclopropyl   benzyl          H             
400                                                                       
   trifluoromethyl  SO.sub.2 NHC(O)NH                                     
                              2-butyl       benzyl          H             
401                                                                       
   trifluoromethyl  SO.sub.2 NHC(O)NH                                     
                              2-butyl       benzyl          H             
402                                                                       
   trifluoromethyl  SO.sub.2 NHC(O)NH                                     
                              cyclobutyl    3-pyridylmethyl H             
403                                                                       
   trifluoromethyl  SO.sub.2 NHC(O)NH                                     
                              cyclopropyl   4-pyridylmethyl H             
__________________________________________________________________________
 
    
     
                                           TABLE VI                                
__________________________________________________________________________
 ##STR177##                                                               
Ex.                                                                       
No.                                                                       
   R.sup.1                                                                
          W       X        R.sup.2 R.sup.3                                
                                          R.sup.4                         
                                                R.sup.18                  
__________________________________________________________________________
404                                                                       
   benzyl C(O)NH  C(O)NH   benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
405                                                                       
   benzyl C(O)NH  C(O)O    benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
406                                                                       
   benzyl C(O)NH  C(O)     benzyl  2-butyl                                
                                          2-pyridyl-                      
                                                H                         
                                          methyl                          
407                                                                       
   benzyl C(O)NH  CH.sub.2 C(O)                                           
                           benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
408                                                                       
   benzyl C(O)NH  CH.sub.2 C(O)CH.sub.2                                   
                           benzyl  2-butyl                                
                                          3-pyridyl-                      
                                                H                         
                                          methyl                          
409                                                                       
   benzyl C(O)NH  C(Q)CH.sub.2                                            
                           benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
410                                                                       
   benzyl C(O)NH  SO.sub.2 NH                                             
                           benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
411                                                                       
   benzyl C(O)NH  SO.sub.2 benzyl  2-butyl                                
                                          4-pyridyl-                      
                                                H                         
                                          methyl                          
412                                                                       
   benzyl C(O)NH  CH.sub.2 OCH.sub.2                                      
                           benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
413                                                                       
   benzyl C(O)NH  CH.sub.2 O                                              
                           benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
414                                                                       
   benzyl C(O)NH  CH.sub.2 NCH.sub.3                                      
                           benzyl  2-butyl                                
                                          2-pyridyl-                      
                                                H                         
                                          methyl                          
415                                                                       
   benzyl C(O)NH  CH.sub.2 NH                                             
                           benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
416                                                                       
   benzyl C(O)NH  CH.sub.2 CH.sub.2                                       
                           benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
417                                                                       
   benzyl C(O)NH  CHCH     benzyl  2-butyl                                
                                          3-pyridyl-                      
                                                H                         
                                          methyl                          
418                                                                       
   benzyl C(O)NH  CH(OH)CH(OH)                                            
                           benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
419                                                                       
   benzyl C(O)NH  CH(OH)CH.sub.2                                          
                           benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
420                                                                       
   benzyl C(O)NH  CH.sub.2 CH(OH)                                         
                           benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
421                                                                       
   benzyl C(O)NH  CH(OH)   benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
422                                                                       
   benzyl C(O)NH  C(N[Me]2)N                                              
                           benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
423                                                                       
   benzyl C(O)NH  C(OEt)N  benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
424                                                                       
   benzyl C(O)NH  C(Cl)N   benzyl  2-butyl                                
                                          2-pyridyl-                      
                                                H                         
                                          methyl                          
425                                                                       
   benzyl C(O)NH  SO.sub.2 NH                                             
                           benzyl  2-butyl                                
                                          benzyl                          
                                                CH.sub.3                  
426                                                                       
   benzyl NHC(O)NH                                                        
                  C(O)NH   benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
427                                                                       
   2-pyridyl-                                                             
          NHC(O)NH                                                        
                  C(O)NH   benzyl  2-butyl                                
                                          3-pyridyl-                      
                                                H                         
   methyl                                 methyl                          
428                                                                       
   2-pyrimidinyl                                                          
          NHC(O)NH                                                        
                  C(O)NH   benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
429                                                                       
   benzyl NHC(O)NH                                                        
                  C(O)NH   3-(methyl-                                     
                                   2-butyl                                
                                          benzyl                          
                                                H                         
                           amino)propyl                                   
430                                                                       
   naphthyl                                                               
          NHC(O)NH                                                        
                  C(O)NH   benzyl  cyclopropyl                            
                                          benzyl                          
                                                H                         
431                                                                       
   benzyl NHC(O)NH                                                        
                  C(O)NH   benzyl  cyclopropyl                            
                                          4-chloro-                       
                                                H                         
                                          benzyl                          
432                                                                       
   benzyl NHC(O)NH                                                        
                  C(O)NH   benzyl  2-butyl                                
                                          4-pyridyl                       
                                                H                         
433                                                                       
   benzyl NHC(O)NH                                                        
                  C(O)NH   2-acetamido-                                   
                                   2-butyl                                
                                          benzyl                          
                                                H                         
434                                                                       
   benzyl NHC(O)NH                                                        
                  C(O)NH   2-(dimethyl-                                   
                                   2-propyl                               
                                          benzyl                          
                                                H                         
                           aminoethyl)                                    
435                                                                       
   benzyl NHC(O)NH                                                        
                  C(O)NH   benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
436                                                                       
   benzyl NHC(O)NH                                                        
                  SO.sub.2 NH                                             
                           benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
437                                                                       
   benzyl NHC(O)NH                                                        
                  SO.sub.2 NH                                             
                           3-(methyl-                                     
                                   n-propyl                               
                                          benzyl                          
                                                H                         
                           amino)propyl                                   
438                                                                       
   benzyl NHC(O)NH                                                        
                  SO.sub.2 NH                                             
                           isobutyl                                       
                                   2-propyl                               
                                          benzyl                          
                                                H                         
439                                                                       
   naphthyl                                                               
          NHC(O)NH                                                        
                  SO.sub.2 NH                                             
                           benzyl  2-butyl                                
                                          benzyl                          
                                                CH.sub.3                  
440                                                                       
   benzyl NHC(O)NH                                                        
                  SO.sub.2 NH                                             
                           benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
441                                                                       
   benzyl OC(O)NH C(O)NH   benzyl  2-butyl                                
                                          2-pyridyl-                      
                                                H                         
                                          methyl                          
442                                                                       
   2-pyridyl-                                                             
          OC(O)NH C(O)O    benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
   methyl                                                                 
443                                                                       
   benzyl OC(O)NH C(O)     benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
444                                                                       
   benzyl OC(O)NH CH.sub.2 C(O)                                           
                           benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
445                                                                       
   benzyl OC(O)NH CH.sub.2 C(O)CH.sub.2                                   
                           benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
446                                                                       
   benzyl OC(O)NH C(O)CH.sub.2                                            
                           benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
447                                                                       
   benzyl OC(O)NH SO.sub.2 NH                                             
                           benzyl  2-butyl                                
                                          benzyl                          
                                                H                         
__________________________________________________________________________
 
    
     
                                           TABLE VII                               
__________________________________________________________________________
 ##STR178##                                                               
Ex. No.                                                                   
     R.sup.1  W       R.sup.3   R.sup.4  R.sup.18                         
__________________________________________________________________________
448                                                                       
449  benzyl   C(S)    2-propyl  benzyl   H                                
450  benzyl   C(S)NH  2-propyl  benzyl   H                                
451  benzyl   HNSO.sub.2 NH                                               
                      2-butyl   2-pyridylmethyl                           
                                         H                                
452  benzyl   SO.sub.2                                                    
                      2-propyl  benzyl   H                                
453  2,4-difluoro-                                                        
              SO.sub.2 NH                                                 
                      2-butyl   3-pyridylmethyl                           
                                         H                                
     phenyl                                                               
454  4&#39;-methylphenyl                                                      
              SO.sub.2 NH                                                 
                      2-butyl   benzyl   H                                
455  benzyl   SO.sub.2 NH                                                 
                      2-(methyl-                                          
                                benzyl   H                                
                      amino)ethyl                                         
456  benzyl   SO.sub.2 NH                                                 
                      2-furanylmethyl                                     
                                4-pyridylmethyl                           
                                         H                                
457  benzyl   SO.sub.2 NH                                                 
                      2-propyl  benzyl   H                                
458  benzyl   SO.sub.2 NH                                                 
                      2-propyl  benzyl   Et                               
459  benzyl   SO.sub.2 NH                                                 
                      2-propyl  3&#39;-trifluoro-                             
                                         H                                
                                methylbenzyl                              
460  benzyl   SO.sub.2 NH                                                 
                      2-propyl  2&#39;,4&#39;-difluoro-                           
                                         H                                
                                benzyl                                    
461  benzyl   SO.sub.2 NH                                                 
                      2-propyl  3-phenylpropyl                            
                                         H                                
462  benzyl   SO.sub.2 NH                                                 
                      2-propyl  1-pyrrolylethyl                           
                                         H                                
463  benzyl   SO.sub.2 NH                                                 
                      2-propyl  2-(4-chloro-                              
                                         H                                
                                phenyl)ethyl                              
464  benzyl   SO.sub.2 NH                                                 
                      2-propyl  1-phenylethyl                             
                                         H                                
465  benzyl   SO.sub.2 NH                                                 
                      3-hydroxy-1-propyl                                  
                                1-phenylethyl                             
                                         H                                
466  benzyl   SO.sub.2 NH                                                 
                      cyclobutyl                                          
                                2-pyridylmethyl                           
                                         H                                
467  benzyl   SO.sub.2 NH                                                 
                      cyclopropyl                                         
                                benzyl   H                                
468  benzyl   SO.sub.2 NH                                                 
                      methylthiomethyl                                    
                                1-phenylethyl                             
                                         H                                
469  cyclohexylethyl                                                      
              SO.sub.2 NH                                                 
                      2-butyl   benzyl   H                                
470  nonafluorobutyl                                                      
              SO.sub.2 NH                                                 
                      2-butyl   benzyl   H                                
471  phenyl   SO.sub.2 NH                                                 
                      2-butyl   2-pyridylmethyl                           
                                         H                                
472  trifluoromethyl                                                      
              SO.sub.2 NH                                                 
                      2-butyl   benzyl   H                                
473  benzyl   NHC(S)NH                                                    
                      2-butyl   benzyl   H                                
474  benzyl   NHC(S)NH                                                    
                      2-butyl   3-pyridylmethyl                           
                                         CH.sub.3                         
475  benzyl   NHC(S)NH                                                    
                      2-propyl  benzyl   H                                
476  benzyl   NHC(S)NH                                                    
                      2-propyl  2-naphthylmethyl                          
                                         H                                
477  benzyl   CH.sub.2 O                                                  
                      2-propyl  benzyl   H                                
478  benzyl   CH.sub.2 OCH.sub.2                                          
                      2-propyl  2-pyridylmethyl                           
                                         H                                
479  benzyl   CH.sub.2 CH.sub.2                                           
                      2-propyl  benzyl   H                                
480  benzyl   CHCH    2-propyl  benzyl   H                                
__________________________________________________________________________
 
    
     
                                           TABLE VIII                              
__________________________________________________________________________
 ##STR179##                                                               
Ex.                                                                       
No. R.sup.1                                                               
        W       X      R.sup.2                                            
                              R.sup.3                                     
                                   R.sup.4                                
                                          R.sup.18                        
__________________________________________________________________________
481                                                                       
482                                                                       
483 benzyl                                                                
        C(O)NH  C(O)NH benzyl 2-butyl                                     
                                   benzyl H                               
484 benzyl                                                                
        C(O)NH  C(O)O  benzyl 2-butyl                                     
                                   4-chloro-                              
                                          H                               
                                   benzyl                                 
485 benzyl                                                                
        C(O)NH  C(O)   benzyl 2-butyl                                     
                                   benzyl H                               
486 benzyl                                                                
        C(O)NH  CH.sub.2 C(O)                                             
                       benzyl 2-butyl                                     
                                   2-pyridyl-                             
                                          H                               
                                   methyl                                 
487 benzyl                                                                
        NHC(O)NH                                                          
                C(O)NH 2-(dimethyl-                                       
                              2-propyl                                    
                                   benzyl H                               
                       aminoethyl)                                        
488 benzyl                                                                
        NHC(O)NH                                                          
                C(O)NH benzyl 2-butyl                                     
                                   benzyl H                               
489 benzyl                                                                
        NHC(O)NH                                                          
                SO.sub.2 NH                                               
                       benzyl 2-butyl                                     
                                   benzyl H                               
__________________________________________________________________________
 
    
     
                                           TABLE IX                                
__________________________________________________________________________
 ##STR180##                                                               
Ex.                                                                       
No.                                                                       
   R.sup.1   W         R.sup.3    R.sup.4     R.sup.18                    
__________________________________________________________________________
490                                                                       
491                                                                       
   benzyl    SO.sub.2 NH                                                  
                       2-propyl   1-phenylethyl                           
                                              H                           
492                                                                       
   benzyl    SO.sub.2 NH                                                  
                       3-hydroxy-1-propyl                                 
                                  1-phenylethyl                           
                                              H                           
493                                                                       
   benzyl    SO.sub.2 NH                                                  
                       methylthiomethyl                                   
                                  1-phenylethyl                           
                                              H                           
494                                                                       
   phenyl    SO.sub.2 NHC(O)NH                                            
                       2-butyl    2-phenylethyl                           
                                              H                           
495                                                                       
   phenyl    SO.sub.2 NHC(O)NH                                            
                       2-butyl    3&#39;-carbomethoxybenzyl                   
                                              H                           
496                                                                       
   benzyl    OC(O)NH   2-propyl   3-naphthylmethyl                        
                                              H                           
497                                                                       
   benzyl    OC(O)NH   2-propyl   4&#39;-(5-tetra-                            
                                              H                           
                                  zolyl)benzyl                            
498                                                                       
   benzyl    OC(O)NH   2-propyl   4&#39;-benzyloxybenzyl                      
                                              H                           
499                                                                       
   benzyl    OC(O)NH   2-propyl   4&#39;-phenoxybenzyl                        
                                              H                           
500                                                                       
   benzyl    C(O)NH    2-butyl    4&#39;-trifluoro-                           
                                              H                           
                                  methylbenzyl                            
501                                                                       
   2-pyridylmethyl                                                        
             C(O)NH    2-butyl    benzyl      H                           
502                                                                       
   benzyl    C(O)NH    2-butyl    benzyl      H                           
503                                                                       
   benzyl    C(O)NH    2-butyl    2-pyridylmethyl                         
                                              CH.sub.3                    
504                                                                       
   benzyl    C(O)NH    cyclobutyl benzyl      H                           
505                                                                       
   benzyl    C(O)NH    cyclobutylmethyl                                   
                                  benzyl      H                           
506                                                                       
   benzyl    C(O)NH    2-butyl    benzyl      H                           
507                                                                       
   phenylethyl                                                            
             C(O)NH    2-butyl    3-pyridylmethyl                         
                                              H                           
508                                                                       
   benzyl    C(O)NHNH  2-propyl   benzyl      H                           
509                                                                       
   benzyl    C(O)O     2-propyl   benzyl      H                           
510                                                                       
   benzyl    CH.sub.2 OCH.sub.2                                           
                       2-propyl   benzyl      H                           
511                                                                       
   benzyl    CH.sub.2 CH.sub.2                                            
                       2-propyl   4-pyridylmethyl                         
                                              H                           
512                                                                       
   benzyl    CH.sub.2 O                                                   
                       2-propyl   benzyl      H                           
513                                                                       
   benzyl    CHCH      2-propyl   benzyl      H                           
514                                                                       
   benzyl    HNSO.sub.2 NH                                                
                       2-butyl    benzyl      H                           
515                                                                       
   benzyl    NN        2-propyl   benzyl      H                           
516                                                                       
   benzyl    NHNH      2-propyl   benzyl      H                           
517                                                                       
   adamantyl NHC(O)NH  2-butyl    2-pyridylmethyl                         
                                              H                           
518                                                                       
   benzyl    NHC(O)NH  2-butyl    benzyl      H                           
519                                                                       
   benzyl    NHC(O)NH  2-butyl    benzyl      CF.sub.3                    
520                                                                       
   benzyl    NHC(O)NH  2-propyl   benzyl      H                           
521                                                                       
   benzyl    NHC(O)NH  benzyl     3-pyridylmethyl                         
                                              H                           
522                                                                       
   benzyl    NHC(O)NH  CH.sub.2 CF.sub.3                                  
                                  benzyl      H                           
523                                                                       
   benzyl    NHC(O)NH  CH.sub.2 CH.sub.2 C(O)NH                           
                                  benzyl      H                           
524                                                                       
   benzyl    NHC(O)NH  cyclobutyl benzyl      H                           
525                                                                       
   benzyl    NHC(O)NH  cyclobutyl benzyl      CF.sub.3                    
526                                                                       
   benzyl    NHC(O)NH  cyclobutylmethyl                                   
                                  4-pyridylmethyl                         
                                              H                           
527                                                                       
   benzyl    NHC(O)NH  cyclopentylmethyl                                  
                                  benzyl      H                           
528                                                                       
   benzyl    NHC(O)NH  cyclopropyl                                        
                                  benzyl      H                           
529                                                                       
   benzyl    NHC(O)NH  cyclopropylmethyl                                  
                                  benzyl      H                           
530                                                                       
   cis-2-deca-                                                            
             NHC(O)NH  2-butyl    benzyl      H                           
   hydronaphthylmethyl                                                    
531                                                                       
   cis-2-deca-                                                            
             NHC(O)NH  2-butyl    benzyl      CF.sub.3                    
   hydronaphthylmethyl                                                    
532                                                                       
   2-hydroxy-3,3-                                                         
             NHC(O)NH  2-butyl    benzyl      H                           
   dimethylpropyl                                                         
533                                                                       
   2-hydroxy-3,3-                                                         
             NHC(O)NH  2-butyl    benzyl      CF.sub.3                    
   dimethylpropyl                                                         
534                                                                       
   2-hydroxy-                                                             
             NHC(O)NH  2-butyl    2-pyridylmethyl                         
                                              H                           
   indanylmethyl                                                          
535                                                                       
   benzyl    OC(O)NH   1-methoxy-2-propyl                                 
                                  benzyl      H                           
536                                                                       
   benzyl    OC(O)NH   2&#39;-hydroxy-                                        
                                  benzyl      H                           
                       cyclopentylmethyl                                  
537                                                                       
   benzyl    OC(O)NH   2,2,2-trichloroethyl                               
                                  3-pyridylmethyl                         
                                              H                           
538                                                                       
   benzyl    OC(O)NH   2,2,2-trichloroethyl                               
                                  benzyl      H                           
539                                                                       
   benzyl    OC(O)NH   2-butyl    benzyl      H                           
540                                                                       
   benzyl    OC(O)NH   2-propyl   benzyl      H                           
541                                                                       
   benzyl    OC(O)NH   2-propyl   benzyl      CF.sub.3                    
542                                                                       
   2-benzimida-                                                           
             OC(O)NH   2-butyl    benzyl      H                           
   zolylmethyl                                                            
543                                                                       
   2-naphthyl-                                                            
             OC(O)NH   2-butyl    4-pyridylmethyl                         
                                              H                           
   methyl                                                                 
544                                                                       
   2-pyridylmethyl                                                        
             OC(O)NH   2-butyl    benzyl      H                           
545                                                                       
   CH.sub.3 SO.sub.2 CH.sub.2 CH.sub.2                                    
             OC(O)NH   2-butyl    benzyl      H                           
546                                                                       
   cyclopentylethyl                                                       
             OC(O)NH   2-butyl    benzyl      H                           
547                                                                       
   F.sub.2 HCOC.sub.6 H.sub.4 CH.sub.2                                    
             OC(O)NH   2-butyl    benzyl      H                           
548                                                                       
   2,4-difluoro-                                                          
             SO.sub.2 NH                                                  
                       2-butyl    benzyl      H                           
   phenyl                                                                 
549                                                                       
   4&#39;-methylphenyl                                                        
             SO.sub.2 NH                                                  
                       2-butyl    benzyl      H                           
550                                                                       
   benzyl    SO.sub.2 NH                                                  
                       2-(methylamino)ethyl                               
                                  benzyl      H                           
551                                                                       
   benzyl    SO.sub.2 NH                                                  
                       2-furanylmethyl                                    
                                  2-pyridylmethyl                         
                                              H                           
552                                                                       
   benzyl    SO.sub.2 NH                                                  
                       2-propyl   benzyl      H                           
553                                                                       
   benzyl    SO.sub.2 NH                                                  
                       cyclobutyl benzyl      H                           
554                                                                       
   benzyl    SO.sub.2 NH                                                  
                       cyclopropyl                                        
                                  benzyl      H                           
555                                                                       
   4&#39;-methylphenyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       2-(dimethylamino)-                                 
                                  benzyl      H                           
                       ethyl                                              
556                                                                       
   4&#39;-methylphenyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       2-butyl    benzyl      H                           
557                                                                       
   4&#39;-methylphenyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       2-butyl    benzyl      H                           
558                                                                       
   4&#39;-methylphenyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       benzyl     benzyl      H                           
559                                                                       
   4&#39;-methylphenyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       CH.sub.2 CH.sub.2 OH                               
                                  3-pyridylmethyl                         
                                              H                           
560                                                                       
   4&#39;-methylphenyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       cyclobutyl benzyl      H                           
561                                                                       
   phenyl    SO.sub.2 NHC(O)NH                                            
                       2-butyl    4-pyridylmethyl                         
                                              CF.sub.3                    
562                                                                       
   phenyl    SO.sub.2 NHC(O)NH                                            
                       cyclopropyl                                        
                                  benzyl      H                           
563                                                                       
   trifluoromethyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       2-butyl    benzyl      H                           
564                                                                       
   trifluoromethyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       2-butyl    benzyl      H                           
565                                                                       
   trifluoromethyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       cyclobutyl benzyl      H                           
566                                                                       
   trifluoromethyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       cyclopropyl                                        
                                  benzyl      H                           
__________________________________________________________________________
 
    
     
                                           TABLE X                                 
__________________________________________________________________________
 ##STR181##                                                               
Ex.                                                                       
No.                                                                       
   R.sup.1  W       X        R.sup.2  R.sup.3                             
                                            R.sup.4 R.sup.12              
__________________________________________________________________________
567                                                                       
568                                                                       
   benzyl   C(O)NH  C(O)NH   benzyl   2-butyl                             
                                            benzyl  H                     
569                                                                       
   benzyl   C(O)NH  C(O)O    benzyl   2-propyl                            
                                            benzyl  H                     
570                                                                       
   benzyl   C(O)NH  CH.sub.2 C(O)CH.sub.2                                 
                             4-chlorophenyl                               
                                      cyclopropyl                         
                                            benzyl  H                     
571                                                                       
   benzyl   C(O)NH  C(O)CH.sub.2                                          
                             benzyl   ethyl benzyl  H                     
572                                                                       
   benzyl   C(O)NH  SO.sub.2 NH                                           
                             benzyl   cyclobutyl                          
                                            benzyl  H                     
573                                                                       
   benzyl   C(O)NH  CH.sub.2 NCH.sub.3                                    
                             2-(dimethyl-                                 
                                      2-butyl                             
                                            benzyl  H                     
                             aminoethyl)                                  
574                                                                       
   benzyl   C(O)NH  CH.sub.2 NH                                           
                             benzyl   2-butyl                             
                                            benzyl  H                     
575                                                                       
   benzyl   C(O)NH  CH.sub.2 CH.sub.2                                     
                             naphthyl 2-butyl                             
                                            4-fluoro-                     
                                                    H                     
                                            phenyl                        
576                                                                       
   benzyl   C(O)NH  CHCH     benzyl   2-butyl                             
                                            benzyl  H                     
577                                                                       
   benzyl   C(O)NH  CH(OH)CH(OH)                                          
                             2-acetamido                                  
                                      2-butyl                             
                                            naphthyl                      
                                                    H                     
578                                                                       
   3-trifluoro-                                                           
            C(O)NH  CH(OH)CH.sub.2                                        
                             benzyl   2-butyl                             
                                            benzyl  H                     
   methylbenzyl                                                           
579                                                                       
   benzyl   C(O)NH  CH.sub.2 CH(OH)                                       
                             benzyl   2-butyl                             
                                            4-meth- H                     
                                            oxyphenyl                     
580                                                                       
   benzyl   C(O)NH  CH(OH)   4-methanesulfonyl                            
                                      2-butyl                             
                                            benzyl  H                     
581                                                                       
   benzyl   C(O)NH  SO.sub.2 NH                                           
                             benzyl   2-butyl                             
                                            2,4-di- CH.sub.3              
                                            chlorophenyl                  
582                                                                       
   benzyl   NHC(O)NH                                                      
                    C(O)NH   benzyl   2-butyl                             
                                            benzyl  H                     
583                                                                       
   2-pyridyl-                                                             
            NHC(O)NH                                                      
                    C(O)NH   benzyl   2-butyl                             
                                            benzyl  H                     
   methyl                                                                 
584                                                                       
   2,4-dimethoxy-                                                         
            NHC(O)NH                                                      
                    C(O)NH   benzyl   2-butyl                             
                                            benzyl  H                     
   benzyl                                                                 
585                                                                       
   benzyl   NHC(O)NH                                                      
                    C(O)NH   3-(methyl-                                   
                                      2-butyl                             
                                            benzyl  H                     
                             amino)-propyl                                
586                                                                       
   naphthyl NHC(O)NH                                                      
                    C(O)NH   benzyl   cyclopropyl                         
                                            benzyl  H                     
587                                                                       
   benzyl   NHC(O)NH                                                      
                    C(O)NH   2-imi-   cyclopropyl                         
                                            4-chloro-                     
                                                    H                     
                             dazolylmethyl  benzyl                        
588                                                                       
   benzyl   NHC(O)NH                                                      
                    C( O)NH  benzyl   2-butyl                             
                                            4-pyridyl                     
                                                    H                     
589                                                                       
   benzyl   NHC(O)NH                                                      
                    C(O)NH   2-acetamido                                  
                                      2-butyl                             
                                            benzyl  H                     
590                                                                       
   benzyl   NHC(O)NH                                                      
                    C(O)NH   2-(dimethyl-                                 
                                      2-propyl                            
                                            benzyl  H                     
                             aminoethyl)                                  
591                                                                       
   benzyl   NHC(O)NH                                                      
                    C(O)NH   benzyl   2-butyl                             
                                            benzyl  H                     
592                                                                       
   benzyl   NHC(O)NH                                                      
                    SO.sub.2 NH                                           
                             benzyl   2-butyl                             
                                            benzyl  H                     
593                                                                       
   benzyl   NHC(O)NH                                                      
                    SO.sub.2 NH                                           
                             3-(methyl-                                   
                                      n-propyl                            
                                            benzyl  H                     
                             amino)propyl                                 
594                                                                       
   benzyl   NHC(O)NH                                                      
                    SO.sub.2 NH                                           
                             isobutyl 2-propyl                            
                                            benzyl  H                     
595                                                                       
   naphthyl NHC(O)NH                                                      
                    SO.sub.2 NH                                           
                             benzyl   2-butyl                             
                                            benzyl  H                     
596                                                                       
   benzyl   NHC(O)NH                                                      
                    SO.sub.2 NH                                           
                             3-indolylmethyl                              
                                      2-butyl                             
                                            benzyl  CH.sub.3              
597                                                                       
   benzyl   OC(O)NH C(O)NH   benzyl   2-butyl                             
                                            benzyl  H                     
598                                                                       
   benzyl   OC(O)NH C(O)O    benzyl   2-propyl                            
                                            benzyl  H                     
599                                                                       
   benzyl   OC(O)NH CH.sub.2 C(O)CH.sub.2                                 
                             4-chlorophenyl                               
                                      cyclopropyl                         
                                            benzyl  H                     
600                                                                       
   adamantyl                                                              
            OC(O)NH C(O)CH.sub.2                                          
                             benzyl   ethyl benzyl  H                     
601                                                                       
   benzyl   OC(O)NH SO.sub.2 NH                                           
                             benzyl   cyclobutyl                          
                                            benzyl  H                     
602                                                                       
   benzyl   OC(O)NH CH.sub.2 NCH.sub.3                                    
                             2-(dimethyl-                                 
                                      2-butyl                             
                                            benzyl  H                     
                             aminoethyl)                                  
603                                                                       
   cyclohexylmethyl                                                       
            OC(O)NH CH.sub.2 NH                                           
                             benzyl   2-butyl                             
                                            benzyl  H                     
604                                                                       
   benzyl   OC(O)NH CH.sub.2 CH.sub.2                                     
                             naphthyl 2-butyl                             
                                            4-fluoro-                     
                                                    H                     
                                            phenyl                        
__________________________________________________________________________
 
    
     
                                           TABLE XI                                
__________________________________________________________________________
 ##STR182##                                                               
Ex.                                                                       
No.                                                                       
   R.sup.1   W         R.sup.3   R.sup.4     R.sup.18                     
__________________________________________________________________________
605                                                                       
   2-pyridylmethyl                                                        
             C(O)      2-propyl  benzyl      H                            
606                                                                       
   benzyl    C(O)      2-butyl   cyclohexylmethyl                         
                                             H                            
607                                                                       
   benzyl    C(O)      2-propyl  benzyl      H                            
608                                                                       
   trifluoromethyl                                                        
             C(O)      2-propyl  2-pyridylmethyl                          
                                             H                            
609                                                                       
   benzyl    C(O)CH.sub.2                                                 
                       2-propyl  benzyl      H                            
610                                                                       
   2-pyridylmethyl                                                        
             C(O)NH    2-butyl   3-pyridylmethyl                          
                                             H                            
611                                                                       
   benzyl    C(O)NH    2-butyl   benzyl      H                            
612                                                                       
   benzyl    C(O)NH    2-butyl   benzyl      CH.sub.3                     
613                                                                       
   benzyl    C(O)NH    2-butyl   4&#39;-trifluoro-                            
                                             H                            
                                 methylbenzyl                             
614                                                                       
   benzyl    C(O)NH    cyclobutyl                                         
                                 benzyl      H                            
615                                                                       
   benzyl    C(O)NH    cyclobutylmethyl                                   
                                 benzyl      H                            
616                                                                       
   methyl    C(O)NH    2-butyl   3-pyridylmethyl                          
                                             H                            
617                                                                       
   phenylethyl                                                            
             C(O)NH    2-butyl   benzyl      H                            
618                                                                       
   benzyl    C(O)NHNH  2-propyl  benzyl      H                            
619                                                                       
   benzyl    C(O)O     2-propyl  benzyl      H                            
620                                                                       
   benzyl    C(S)      2-propyl  4-pyridylmethyl                          
                                             H                            
621                                                                       
   benzyl    C(S)NH    2-propyl  benzyl      H                            
622                                                                       
   benzyl    C(Cl)N    2-propyl  benzyl      H                            
623                                                                       
   2-pyridylmethyl                                                        
             C(NHMe)N  2-propyl  benzyl      H                            
624                                                                       
   3-methylpropyl                                                         
             C(NHMe)N  2-propyl  benzyl      H                            
625                                                                       
   benzyl    C(NHMe)N  2-propyl  2-pyridylmethyl                          
                                             H                            
626                                                                       
   benzyl    C(NHMe)N  2-propyl  benzyl      CH.sub.3                     
627                                                                       
   benzyl    C(NHMe)N  2-propyl  4-(HCF.sub.2 O)C.sub.6 H.sub.4 CH.sub.2  
628                                                                       
   benzyl    C(OCH.sub.2 CH.sub.3)N                                       
                       2-propyl  benzyl      H                            
629                                                                       
   benzyl    C(OCH.sub.2 CH.sub.3)N                                       
                       2-propyl  4&#39;-trifluoro-                            
                                             H                            
                                 methylbenzyl                             
630                                                                       
   benzyl    C(OCH.sub.2 CH.sub.3)N                                       
                       2-propyl  4&#39;-chlorobenzyl                          
                                             H                            
631                                                                       
   benzyl    CH.sub.2 OCH.sub.2                                           
                       2-propyl  benzyl      H                            
632                                                                       
   benzyl    CH.sub.2 CH.sub.2                                            
                       2-propyl  benzyl      H                            
633                                                                       
   benzyl    CH.sub.2 CHOH                                                
                       2-propyl  3-pyridylmethyl                          
                                             H                            
634                                                                       
   benzyl    CH.sub.2 O                                                   
                       2-propyl  benzyl      H                            
635                                                                       
   benzyl    CH.sub.2 OH                                                  
                       2-propyl  benzyl      H                            
636                                                                       
   benzyl    CHCH      2-propyl  benzyl      H                            
637                                                                       
   benzyl    CHOHCH.sub.2                                                 
                       2-propyl  4-pyridylmethyl                          
                                             H                            
638                                                                       
   benzyl    CHOHCHOH  2-propyl  benzyl      H                            
639                                                                       
   benzyl    HNC(S)NH  2-propyl  benzyl      H                            
640                                                                       
   benzyl    HNSO.sub.2                                                   
                       2-butyl   benzyl      H                            
641                                                                       
   benzyl    HNSO.sub.2 NH                                                
                       2-butyl   benzyl      H                            
642                                                                       
   benzyl    NN        2-propyl  2-pyridylmethyl                          
                                             H                            
643                                                                       
   benzyl    NHNH      2-propyl  benzyl      H                            
644                                                                       
   2-hydroxy-3,3-                                                         
             NHC(O)NH  2-butyl   benzyl      H                            
   dimethylpropyl                                                         
645                                                                       
   4-t-butyl-                                                             
             NHC(O)NH  2-butyl   benzyl      H                            
   phenylmethyl                                                           
646                                                                       
   adamantyl NHC(O)NH  2-butyl   benzyl      H                            
647                                                                       
   benzyl    NHC(O)NH  2-butyl   2-pyridylmethyl                          
                                             H                            
648                                                                       
   benzyl    NHC(O)NH  2-butyl   benzyl      CH.sub.3                     
649                                                                       
   benzyl    NHC(O)NH  2-propyl  benzyl      H                            
650                                                                       
   benzyl    NHC(O)NH  2-propyl  3-pyrrazolylmethyl                       
                                             H                            
651                                                                       
   benzyl    NHC(O)NH  2-propyl  3-(trifluoro-                            
                                             H                            
                                 methanesulfonyl)propyl                   
652                                                                       
   benzyl    NHC(O)NH  2-propyl  4-(1-methyl)piperi-                      
                                             H                            
                                 dinylmethyl                              
653                                                                       
   benzyl    NHC(O)NH  2-thiozolylmethyl                                  
                                 benzyl      H                            
654                                                                       
   benzyl    NHC(O)NH  cyclobutyl                                         
                                 3-pyridylmethyl                          
                                             CH.sub.3                     
655                                                                       
   benzyl    NHC(O)NH  cyclobutylmethyl                                   
                                 benzyl      H                            
656                                                                       
   2-pyridylmethyl                                                        
             OC(O)NH   2-butyl   benzyl      H                            
657                                                                       
   9-fluorenylmethyl                                                      
             OC(O)NH   2-butyl   4-pyridylmethyl                          
                                             H                            
658                                                                       
   adamantylmethyl                                                        
             OC(O)NH   2-butyl   benzyl      H                            
659                                                                       
   benzyl    OC(O)NH   1-methoxy-2-propyl                                 
                                 benzyl      H                            
660                                                                       
   benzyl    OC(O)NH   2&#39;-hydroxy-                                        
                                 benzyl      H                            
                       cyclopentylmethyl                                  
661                                                                       
   benzyl    OC(O)NH   2-propyl  benzyl      CH.sub.3                     
662                                                                       
   benzyl    OC(O)NH   2-propyl  3-naphthylmethyl                         
                                             H                            
663                                                                       
   benzyl    OC(O)NH   2-propyl  4&#39;-phenoxybenzyl                         
                                             H                            
664                                                                       
   benzyl    OC(O)NH   2-propyl  4&#39;-benzyloxybenzyl                       
                                             H                            
665                                                                       
   benzyl    OC(O)NH   2-propyl  4&#39;-(5-tetra-                             
                                             H                            
                                 zolyl)benzyl                             
666                                                                       
   benzyl    OCH.sub.2 2-propyl  benzyl      H                            
667                                                                       
   benzyl    OP( O)(OMe)O                                                 
                       2-propyl  benzyl      H                            
668                                                                       
   benzyl    SO.sub.2  2-propyl  2-pyridylmethyl                          
                                             H                            
669                                                                       
   2,4-difluorophenyl                                                     
             SO.sub.2 NH                                                  
                       2-butyl   benzyl      H                            
670                                                                       
   4&#39;-methylphenyl                                                        
             SO.sub.2 NH                                                  
                       2-butyl   benzyl      H                            
671                                                                       
   benzyl    SO.sub.2 NH                                                  
                       2-propyl  3-pyridylmethyl                          
                                             Et                           
672                                                                       
   benzyl    SO.sub.2 NH                                                  
                       2-propyl  3&#39;-tri-     H                            
                                 fluoromethylbenzyl                       
673                                                                       
   benzyl    SO.sub.2 NH                                                  
                       2-propyl  2&#39;,4&#39;-difluorobenzyl                     
                                             H                            
674                                                                       
   nonafluorobutyl                                                        
             SO.sub.2 NH                                                  
                       2-butyl   benzyl      H                            
675                                                                       
   phenyl    SO.sub.2 NH                                                  
                       2-butyl   benzyl      H                            
676                                                                       
   trifluoromethyl                                                        
             SO.sub.2 NH                                                  
                       2-butyl   4-pyridylmethyl                          
                                             H                            
677                                                                       
   2,4-difluorophenyl                                                     
             SO.sub.2 NHC(O)NH                                            
                       2-butyl   benzyl      H                            
678                                                                       
   4&#39;-methylphenyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       2-(dimethyl-                                       
                                 benzyl      H                            
                       amino)ethyl                                        
679                                                                       
   4&#39;-methylphenyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       2-butyl   benzyl      H                            
680                                                                       
   4&#39;-methylphenyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       CH.sub.2 CH.sub.2 OH                               
                                 4-pyridylmethyl                          
                                             H                            
681                                                                       
   4&#39;-methylphenyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       cyclobutyl                                         
                                 benzyl      H                            
682                                                                       
   4&#39;-methylphenyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       cyclohexylmethyl                                   
                                 benzyl      H                            
683                                                                       
   methyl    SO.sub.2 NHC(O)NH                                            
                       2-butyl   3-pyridylmethyl                          
                                             H                            
684                                                                       
   phenyl    SO.sub.2 NHC(O)NH                                            
                       2-butyl   benzyl      H                            
685                                                                       
   phenyl    SO.sub.2 NHC(O)NH                                            
                       2-butyl   benzyl      H                            
686                                                                       
   phenyl    SO.sub.2 NHC(O)NH                                            
                       2-butyl   2&#39;-chlorobenzyl                          
                                             H                            
687                                                                       
   phenyl    SO.sub.2 NHC(O)NH                                            
                       2-butyl   3-naphthylmethyl                         
                                             H                            
688                                                                       
   phenyl    SO.sub.2 NHC(O)NH                                            
                       2-butyl   2-(4-fluoro-                             
                                             H                            
                                 phenyl)ethyl                             
689                                                                       
   phenyl    SO.sub.2 NHC(O)NH                                            
                       2-butyl   2-phenylethyl                            
                                             H                            
690                                                                       
   phenyl    SO.sub.2 NHC(O)NH                                            
                       2-butyl   3&#39;-carbomethoxybenzyl                    
                                             H                            
691                                                                       
   phenyl    SO.sub.2 NHC(O)NH                                            
                       2-butyl   benzyl      CH.sub.3                     
692                                                                       
   phenyl    SO.sub.2 NHC(O)NH                                            
                       cyclopropyl                                        
                                 4-pyridylmethyl                          
                                             H                            
693                                                                       
   trifluoromethyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       2-butyl   benzyl      H                            
694                                                                       
   trifluoromethyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       2-butyl   benzyl      H                            
695                                                                       
   trifluoromethyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       cyclobutyl                                         
                                 2-pyridylmethyl                          
                                             H                            
696                                                                       
   trifluoromethyl                                                        
             SO.sub.2 NHC(O)NH                                            
                       cyclopropyl                                        
                                 benzyl      H                            
__________________________________________________________________________
 
    
     
                                           TABLE XII                               
__________________________________________________________________________
 ##STR183##                                                               
Ex.                                                                       
No.                                                                       
   R.sup.1 W       X        R.sup.2   R.sup.3   R.sup.4                   
                                                      R.sup.18            
__________________________________________________________________________
697                                                                       
   benzyl  OC(O)NH C(O)NH   benzyl    2-butyl   benzyl                    
                                                      H                   
698                                                                       
   benzyl  OC(O)NH C(O)O    benzyl    2-butyl   benzyl                    
                                                      H                   
699                                                                       
   benzyl  OC(O)NH C(O)     2-(dimethyl-                                  
                                      2-butyl   benzyl                    
                                                      H                   
                            amino)ethyl                                   
700                                                                       
   benzyl  OC(O)NH CH.sub.2 C(O)                                          
                            benzyl    2-propyl  benzyl                    
                                                      H                   
701                                                                       
   benzyl  OC(O)NH CH.sub.2 C(O)CH.sub.2                                  
                            benzyl    2-propyl  4-chloro-                 
                                                      H                   
                                                benzyl                    
702                                                                       
   benzyl  OC(O)NH C(Q)CH.sub.2                                           
                            benzyl    2-propyl  benzyl                    
                                                      H                   
703                                                                       
   benzyl  OC(O)NH SO.sub.2 NH                                            
                            3-(methyl-                                    
                                      ethyl     2-pyridyl                 
                                                      H                   
                            amino)propyl        methyl                    
704                                                                       
   benzyl  OC(O)NH SO.sub.2 benzyl    2-thiazolyl-                        
                                                benzyl                    
                                                      H                   
                                      methyl                              
705                                                                       
   benzyl  OC(O)NH CH.sub.2 OCH.sub.2                                     
                            benzyl    cyclobutyl                          
                                                benzyl                    
                                                      H                   
706                                                                       
   benzyl  OC(O)NH CH.sub.2 O                                             
                            benzyl    cyclobutyl-                         
                                                3-pyridyl                 
                                                      H                   
                                      methyl    methyl                    
707                                                                       
   benzyl  OC(O)NH CH.sub.2 NCH.sub.3                                     
                            cyclohexylmethyl                              
                                      2-butyl   benzyl                    
                                                      CH.sub.3            
708                                                                       
   benzyl  OC(O)NH CH.sub.2 NH                                            
                            benzyl    3-cyanopropy                        
                                                benzyl                    
                                                      H                   
709                                                                       
   benzyl  HNC(O)NH                                                       
                   CH.sub.2 CH.sub.2                                      
                            benzyl    2-butyl   3-indolyl                 
                                                      H                   
710                                                                       
   benzyl  C(O)NH  CHCH     benzyl    1-methoxy-2-                        
                                                4-pyridyl-                
                                                      H                   
                                      propyl    methyl                    
711                                                                       
   2-pyridyl-                                                             
           OC(O)NH CH(OH)CH(OH)                                           
                            benzyl    2&#39;-hydroxycyclo-                    
                                                benzyl                    
                                                      H                   
   methyl                             pentylmethyl                        
712                                                                       
   benzyl  OC(O)NH CH(OH)CH.sub.2                                         
                            benzyl    2-propyl  4-fluoro-                 
                                                      H                   
                                                benzyl                    
713                                                                       
   naphthyl                                                               
           OC(O)NH CH.sub.2 CH(OH)                                        
                            4-pyridyl-                                    
                                      2-propyl  benzyl                    
                                                      H                   
                            methyl                                        
714                                                                       
   benzyl  OC(O)NH CH(OH)   benzyl    benzyl    naphthyl                  
                                                      H                   
715                                                                       
   2,3-di- OC(O)NH C(N[Me].sub.2)N                                        
                            4-imida-  2-propyl  benzyl                    
                                                      H                   
   fluorobenzyl             zolylmethyl                                   
716                                                                       
   benzyl  OC(O)NH C(OEt) N benzyl    2-propyl  benzyl                    
                                                      H                   
717                                                                       
   1-cyclo-                                                               
           OC(O)NH C(Cl)N   benzyl    2-propyl  benzyl                    
                                                      H                   
   hexenylmethyl                                                          
__________________________________________________________________________
 
    
     
                                           TABLE XIII                              
__________________________________________________________________________
 ##STR184##                                                               
Ex.                                                                       
No.                                                                       
   R.sup.1      W         R.sup.3                                         
                                 R.sup.4  Y                               
__________________________________________________________________________
718                                                                       
   2-pyridylmethyl                                                        
                C(O)      2-propyl                                        
                                 benzyl   C(Cl)N                          
719                                                                       
   benzyl       C(O)      2-butyl                                         
                                 cyclohexylmethyl                         
                                          C(OEt)N                         
720                                                                       
   benzyl       C(O)CH.sub.2                                              
                          2-propyl                                        
                                 benzyl   C(OEt)N                         
721                                                                       
   2-pyridylmethyl                                                        
                C(O)NH    2-butyl                                         
                                 2-pyridyl-methyl                         
                                          C(NMe.sub.2)N                   
722                                                                       
   benzyl       C(O)NH    2-butyl                                         
                                 benzyl   C(NHMe)N                        
723                                                                       
   benzyl       C(O)NH    2-butyl                                         
                                 benzyl   C(Cl)N                          
724                                                                       
   benzyl       C(O)NH    2-butyl                                         
                                 4&#39;-trifluoro                             
                                          C(NHMe)N                        
                                 methylbenzyl                             
725                                                                       
   benzyl       C(O)NHNH  2-propyl                                        
                                 benzyl   C(NHMe)N                        
726                                                                       
   benzyl       C(O)O     2-propyl                                        
                                 benzyl   C(OMe)N                         
727                                                                       
   benzyl       C(S)      2-propyl                                        
                                 3-pyridyl-methyl                         
                                          C(NHMe.sub.2)N                  
728                                                                       
   benzyl       C(S)NH    2-propyl                                        
                                 benzyl   C(NHMe)N                        
729                                                                       
   benzyl       C(Cl)N    2-propyl                                        
                                 benzyl   C(OEt)N                         
730                                                                       
   2-pyridylmethyl                                                        
                C(NHMe)N  2-propyl                                        
                                 benzyl   C(OEt)N                         
731                                                                       
   3-methylpropyl                                                         
                C(NHMe)N  2-propyl                                        
                                 benzyl   C(NHMe)N                        
732                                                                       
   benzyl       C(NHMe)N  2-propyl                                        
                                 benzyl   C(NHMe)N                        
733                                                                       
   2-pyridylethyl                                                         
                C(OCH.sub.2 CH.sub.3)N                                    
                          2-propyl                                        
                                 benzyl   C(NHMe)N                        
734                                                                       
   benzyl       C(OCH.sub.3)N                                             
                          2-propyl                                        
                                 benzyl   C(OEt)N                         
735                                                                       
   benzyl       CH.sub.2 OCH.sub.2                                        
                          2-propyl                                        
                                 benzyl   C(OEt)N                         
736                                                                       
   benzyl       CH.sub.2 CH.sub.2                                         
                          2-propyl                                        
                                 4-pyridyl-methyl                         
                                          C(NMe.sub.2)N                   
737                                                                       
   benzyl       CH.sub.2 CHOH                                             
                          2-propyl                                        
                                 benzyl   C(NMe)N                         
738                                                                       
   benzyl       CH.sub.2 O                                                
                          2-propyl                                        
                                 benzyl   C(OEt)N                         
739                                                                       
   benzyl       CH.sub.2 OH                                               
                          2-propyl                                        
                                 2-pyridyl-methyl                         
                                          C(OEt)N                         
740                                                                       
   benzyl       CHCH      2-propyl                                        
                                 benzyl   C(NHMe)N                        
741                                                                       
   benzyl       CHOHCH.sub.2                                              
                          2-propyl                                        
                                 benzyl   C(NHMe)N                        
742                                                                       
   benzyl       CHOHCHOH  2-propyl                                        
                                 3-pyridyl-methyl                         
                                          C(OEt)N                         
743                                                                       
   benzyl       HNC(S)NH  2-propyl                                        
                                 benzyl   C(OMe)N                         
744                                                                       
   benzyl       HNSO.sub.2                                                
                          2-butyl                                         
                                 benzyl   C(OEt)N                         
745                                                                       
   benzyl       HNSO.sub.2 NH                                             
                          2-butyl                                         
                                 benzyl   C(OEt)N                         
746                                                                       
   benzyl       NN        2-propyl                                        
                                 4-pyridyl-methyl                         
                                          C(NHMe)N                        
747                                                                       
   benzyl       NHNH      2-propyl                                        
                                 benzyl   C(NHMe)N                        
748                                                                       
   (CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2)                         
                NHC(O)NH  2-butyl                                         
                                 benzyl   C(NHMe)N                        
749                                                                       
   (CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2)                                 
                NHC(O)NH  2-butyl                                         
                                 benzyl   C(OEt)N                         
750                                                                       
   2-hydroxy-3,3-                                                         
                NHC(O)NH  2-butyl                                         
                                 benzyl   C(OMe)N                         
   dimethylpropyl                                                         
751                                                                       
   2-hydroxy-3,3-                                                         
                NHC(O)NH  2-butyl                                         
                                 benzyl   C(Cl)N                          
   dimethylpropyl                                                         
752                                                                       
   2-hydroxy-   NHC(O)NH  2-butyl                                         
                                 benzyl   C(NHMe)N                        
   indanylmethyl                                                          
753                                                                       
   adamantyl    NHC(O)NH  2-butyl                                         
                                 benzyl   C(OEt)N                         
754                                                                       
   benzyl       NHC(O)NH  2-butyl                                         
                                 2-pyridyl-methyl                         
                                          C(OEt)N                         
755                                                                       
   benzyl       NHC(O)NH  2-butyl                                         
                                 benzyl   C(Cl)N                          
756                                                                       
   benzyl       NHC(O)NH  2-propyl                                        
                                 benzyl   C(NHMe)N                        
757                                                                       
   benzyl       NHC(O)NH  2-propyl                                        
                                 2-naphthyl                               
                                          C(NHMe)N                        
                                 methyl                                   
758                                                                       
   benzyl       O         2-propyl                                        
                                 benzyl   C(OEt)N                         
759                                                                       
   2-benzimida- OC(O)NH   2-butyl                                         
                                 3-pyridyl-methyl                         
                                          C(OEt)N                         
   zolylmethyl                                                            
760                                                                       
   2-naphthylmethyl                                                       
                OC(O)NH   2-butyl                                         
                                 benzyl   C(OEt)N                         
761                                                                       
   2-pyridylmethyl                                                        
                OC(O)NH   2-butyl                                         
                                 benzyl   C(OEt)N                         
762                                                                       
   benzyl       OC(O)NH   1-methoxy-                                      
                                 benzyl   C(NMe.sub.2)N                   
                          2-propyl                                        
763                                                                       
   benzyl       OC(O)NH   2-butyl                                         
                                 benzyl   C(NHMe)N                        
764                                                                       
   benzyl       OC(O)NH   2-propyl                                        
                                 4-pyridyl-methyl                         
                                          C(NHMe)N                        
765                                                                       
   benzyl       OC(O)NH   2-propyl                                        
                                 benzyl   C(Cl)N                          
766                                                                       
   benzyl       OCH.sub.2 2-propyl                                        
                                 benzyl   C(OMe)N                         
767                                                                       
   benzyl       OP(O)(OMe)O                                               
                          2-propyl                                        
                                 benzyl   C(OEt)N                         
768                                                                       
   benzyl       SO.sub.2  2-propyl                                        
                                 benzyl   C(NHMe)N                        
769                                                                       
   2,4-di-      SO.sub.2 NH                                               
                          2-butyl                                         
                                 benzyl   C(NHMe)N                        
   fluorophenyl                                                           
770                                                                       
   4&#39;-methylphenyl                                                        
                SO.sub.2 NH                                               
                          2-butyl                                         
                                 benzyl   C(NHMe)N                        
771                                                                       
   benzyl       SO.sub.2 NH                                               
                          2-(methyl-                                      
                                 benzyl   C(NHMe)N                        
                          amino)ethyl                                     
772                                                                       
   benzyl       SO.sub.2 NH                                               
                          2-furanyl-                                      
                                 benzyl   C(NHMe)N                        
                          methyl                                          
773                                                                       
   benzyl       SO.sub.2 NH                                               
                          2-propyl                                        
                                 2-pyridyl-methyl                         
                                          C(NHMe)N                        
774                                                                       
   benzyl       SO.sub.2 NH                                               
                          2-propyl                                        
                                 benzyl   C(Cl)N                          
775                                                                       
   benzyl       SO.sub.2 NHC(O)NH                                         
                          2-butyl                                         
                                 benzyl   C(OEt)N                         
776                                                                       
   cyclohexylethyl                                                        
                SO.sub.2 NHC(O)NH                                         
                          2-butyl                                         
                                 3-pyridyl-methyl                         
                                          C(OEt)N                         
777                                                                       
   methyl       SO.sub.2 NHC(O)NH                                         
                          2-butyl                                         
                                 benzyl   C(OMe)N                         
778                                                                       
   nonafluorobutyl                                                        
                SO.sub.2 NHC(O)NH                                         
                          2-butyl                                         
                                 benzyl   C(OMe)N                         
779                                                                       
   phenyl       SO.sub.2 NHC(O)NH                                         
                          2-butyl                                         
                                 4-pyridyl-methyl                         
                                          C(NHMe)N                        
780                                                                       
   phenyl       SO.sub.2 NHC(O)NH                                         
                          2-butyl                                         
                                 benzyl   C(NMe.sub.2)N                   
781                                                                       
   trifluoromethyl                                                        
                SO.sub.2 NHC(O)NH                                         
                          cyclopropyl                                     
                                 benzyl   C(NHMe)N                        
__________________________________________________________________________
 
    
     
                                           TABLE XIV                               
__________________________________________________________________________
 ##STR185##                                                               
Ex.                                                                       
No.                                                                       
   R.sup.1 W       X     R.sup.2   R.sup.3                                
                                          R.sup.4                         
                                              Y                           
__________________________________________________________________________
782                                                                       
   2-pyridylmethyl                                                        
           C(O)NH  C(O)NH                                                 
                         benzyl    2-butyl                                
                                          benzyl                          
                                              C(NMe.sub.2)N               
783                                                                       
   benzyl  C(O)NH  C(O)NH                                                 
                         3-(dimethyl-                                     
                                   cyclobutyl                             
                                          benzyl                          
                                              C(NHMe)N                    
                         amino)propyl                                     
784                                                                       
   benzyl  C(O)NH  C(O)NH                                                 
                         cyclopentylmethyl                                
                                   2-butyl                                
                                          benzyl                          
                                              C(Cl)N                      
785                                                                       
   benzyl  C(O)NH  C(O)NH                                                 
                         benzyl    cyclopropyl                            
                                          benzyl                          
                                              C(NHMe)N                    
786                                                                       
   benzyl  C(O)NHNH                                                       
                   C(O)NH                                                 
                         4-chloro- 2-propyl                               
                                          benzyl                          
                                              C(NHMe)N                    
                         benzyl                                           
787                                                                       
   benzyl  C(O)O   C(O)NH                                                 
                         3,3,3-triflouro-                                 
                                   2-propyl                               
                                          benzyl                          
                                              C(OMe)N                     
                         ethyl                                            
788                                                                       
   benzyl  C(S)    C( O)NH                                                
                         2-imidazol-                                      
                                   2-propyl                               
                                          benzyl                          
                                              C(NMe.sub.2)N               
                         ylmethyl                                         
__________________________________________________________________________
 
    
     
         TABLE XV
  ##STR186##
  Ex.       No. R.sup.1 W R.sup.3 R.sup.4 R.sup.8 R.sup.10
  789 2-pyridylethyl C(O) 2-propyl benzyl 3-(dimethyl- 2,4-di-
 amino)-1-propyl fluorophenyl 790 2-pyridylmethylC(O) 2-butyl 4-imidazolyl
 - benzyl 4&#39;-methyl-     methyl  phenyl 791 benzyl C(O) 2-butyl cyclohexyl
 methyl CH.sub.2 NHC(O)NHCH.sub.3 benzyl 792 benzyl C(O) 2-propyo benzyl
 CH.sub.2 NHSO.sub.2 CH.sub.3 benzyl 793 benzyl C(O) 2-propyl 2-pyridyl-
 cyclobutyl benzyl     methyl 794 benzyl C(O) benzyl benzyl cyclobutylmeth
 yl benzyl 795 n-propyl C(O) 2-propyl benzyl cyclopropyl benzyl 796
 naphthyl C(O) 2-propyl 3-pyridyl- cyclopropylmethyl benzyl     methyl
 797 phenyl C(O) 2-propyl benzyl methyl benzyl 798 thiophenyl C(O)
 2-propyl benzyl 2-butyl benzyl 799 trifluoromethyl C(O) 2-propyl benzyl
 2-butyl benzyl 800 benzyl C(O)CH.sub.2 2-propyl benzyl 2-butyl benzyl
 801 2-pyridylmethyl C(O)NH 2-butyl 3-pyridyl- 2-propyl benzyl     methyl
 802 benzyl C(O)NH 2-butyl benzyl 2-propyl benzyl 803 benzyl C(O)NH
 2-butyl benzyl 2-propyl benzyl 804 benzyl C(O)NH cyclobutyl 4-pyridyl-
 2-butyl benzyl     methyl 805 benzyl C(O)NH cyclobutyl- benzyl 2-butyl
 cyclohexyl-    methyl   ethyl 806 methyl C(O)NH 2-butyl benzyl 2-(methyl-
  nonafluoro-      amino)ethyl butyl 807 phenylethyl C(O)NH 2-butyl
 benzyl 2-furanylmethyl phenyl 808 benzyl C(O)NHNH 2-propyl benzyl
 2-propyl trifluoro-       methyl 809 benzyl C(O)O 2-propyl benzyl
 2-propyl 2,4-di-       fluorophenyl 810 benzyl C(S) 2-propyl benzyl
 2-propyl 4&#39;-methyl-       phenyl 811 benzyl C(S)NH 2-propyl benzyl
 2-propyl 4&#39;-methyl-       phenyl 812 benzyl C(Cl)N 2-propyl benzyl
 2-propyl 4&#39;-methyl-       phenyl 813 2-pyridyl- C(NHMe)N 2-propyl benzyl
 2-propyl 4&#39;-methyl-  methyl     phenyl 814 3-methylpropyl C(NHMe)N
 2-propyl benzyl 2-propyl 4&#39;-methyl-       phenyl 815 benzyl C(NHMe)N
 2-propyl benzyl 2-propyl 4&#39;-methyl-       phenyl 816 benzyl C(NHMe)N
 2-propyl benzyl 3-hydroxy-1- 4&#39;-methyl-      propyl phenyl 817 2-pyridyle
 thyl C(OCH.sub.2 CH.sub.3)N 2-propyl benzyl cyclobutyl 4&#39;-methyl-
 phenyl 818 3-naphthylmethyl C(OCH.sub.2 CH.sub.3)N 2-propyl benzyl
 cyclopropyl benzyl 819 4&#39;-t-butylbenzyl C(OCH.sub.2 CH.sub.3)N 2-propyl
 benzyl methylthiomethyl cyclohexyl-       ethyl 820 benzyl C(OCH.sub.2
 CH.sub.3)N 2-propyl benzyl 2-butyl methyl 821 benzyl C(OCH.sub.2
 CH.sub.3)N 2-propyl 4&#39;-trifluoro- 2-butyl nonafluoro-     methylbenzyl
 butyl 822 benzyl C(OCH.sub.2 CH.sub.3)N 2-propyl 4&#39;-chloro- 2-butyl
 phenyl     benzyl 823 benzyl C(OCH.sub.2 CH.sub.3)N 2-propyl cyclohexyl-
 2-butyl phenyl     methyl 824 benzyl C(OCH.sub.2 CH.sub.3)N cyclobutyl
 benzyl 2-butyl phenyl 825 benzyl C(OCH.sub.2 CH.sub.3)N cyclobutyl-
 benzyl 2-(dimethyl- phenyl    methyl  amino)ethyl 826 benzyl C(OCH.sub.2
 CH.sub.3)N cyclopropyl benzyl 2-butyl phenyl 827 benzyl C(OCH.sub.3)N
 2-propyl benzyl 2-butyl phenyl 828 benzyl CH.sub.2 OCH.sub.2 2-propyl
 benzyl benzyl phenyl 829 benzyl CH.sub.2 CH.sub.2 2-propyl benzyl
 CH.sub.2 CH.sub.2 OH phenyl 830 benzyl CH.sub.2 CHOH 2-propyl benzyl
 cyclobutyl phenyl 831 benzyl CH.sub.2 O 2-propyl benzyl cyclohexylmethyl
 trifluoromethyl 832 benzyl CH.sub.2 OH 2-propyl benzyl cyclopropyl
 trifluoromethyl 833 benzyl CHCH 2-propyl benzyl 2-butyl trifluoromethyl
 834 benzyl CHOHCH.sub.2 2-propyl benzyl 2-butyl trifluoromethyl 835
 benzyl CHOHCHOH 2-propyl benzyl 2-butyl 2-pyridyl-       ethyl 836
 benzyl HN(S)NH 2-propyl benzyl 2-butyl 2-pyridyl-       methyl 837
 benzyl HNSO.sub.2 2-butyl benzyl 2-butyl benzyl 838 benzyl HNSO.sub.2 NH
 2-butyl benzyl 2-butyl benzyl 839 benzyl NN 2-propyl benzyl 2-butyl
 benzyl 840 benzyl NHNH 2-propyl benzyl 2-butyl benzyl 841 (CH.sub.2
 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2) NHC(O)NH 2-butyl benzyl 2-butyl
 n-propyl 842 (CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2) NHC(O)NH 2-butyl
 benzyl 2-butyl naphthyl 843 2-hydroxy- NHC(O)NH 2-butyl benzyl 2-butyl
 phenyl  indanylmethyl 844 3,5-dimeth- NHC(O)NH 2-butyl benzyl 2-butyl
 thiophenyl  oxyphenyl 845 3-hydroxy-n- NHC(O)NH 2-butyl benzyl cyclopropy
 l trifluoromethyl  propyl 846 4&#39;-nitrobenzyl NHC(O)NH 2-butyl benzyl
 2-butyl benzyl 847 4-benzyloxy- NHC(O)NH 2-butyl benzyl 2-butyl 2-pyridyl
 -  phenylmethyl     methyl 848 4-cyano-n-butyl NHC(O)NH 2-butyl benzyl
 cyclobutyl benzyl 849 4-phenoxy- NHC(O)NH 2-butyl benzyl cyclopropyl
 benzyl  phenylmethyl 850 4-t-butylphenyl- NHC(O)NH 2-butyl benzyl
 cyclobutyl benzyl  methyl 851 adamantyl NHC(O)NH 2-butyl benzyl 2-propylb
 enzyl 852 benzyl NHC(O)NH 2-butyl benzyl 2-butyl methyl 853 benzyl
 NHC(O)NH 2-butyl benzyl 2-butyl phenylethyl 854 benzyl NHC(O)NH 2-propyl
 benzyl 2-propyl benzyl 855 benzyl NHC(O)NH 2-propyl 2-naphth- 2-propyl
 benzyl     ylmethyl 856 benzyl NHC(O)NH 2-propyl 3-naphth- benzyl benzyl
     ylmethyl 857 benzyl NHC(O)NH 2-propyl 1-adamantyl- 2-propyl benzyl
   methyl 858 benzyl NHC(O)NH 2-propyl 4&#39;-hydroxy- 2-propyl benzyl
 benzyl 859 benzyl NHC(O)NH 2-propyl 2-imidazolyl- 2-propyl 2-pyridyl-
  ethyl  methyl 860 benzyl NHC(O)NH 2-propyl 4-pyridinyl- 2-propyl
 3-methyl     methyl  propyl 861 benzyl NHC(O)NH 2-propyl 4-bromophenyl
 2-propyl benzyl 862 benzyl NHC(O)NH 2-propyl cycloheptyl- 2-propyl
 benzyl     methyl 863 benzyl NHC(O)NH 2-propyl 2-thiophenyl- 2-butyl
 2-pyridyl-     methyl  ethyl 864 benzyl NHC(O)NH 2-propyl 3-pyrrazolyl-
 2-butyl 3-naphth-    methyl  methyl 865 benzyl NHC(O)NH benzyl benzyl
 2-butyl 4&#39;-t-butyl-       benzyl 866 benzyl NHC(O)NH CH.sub.2 CF.sub.3
 benzyl cyclobutyl benzyl 867 benzyl NHC(O)NH CH.sub.2 CH.sub.2
  C(O)NH.sub.2 benzyl cyclobutylmethyl benzyl 868 benzyl NHC(O)NH
 CH.sub.2 CH.sub.2 OH benzyl 2-butyl benzyl 869 benzyl NHC(O)NH CH.sub.2
 CHOHCH.sub.3 benzyl 2-butyl benzyl 870 benzyl NHC(O)NH cyclobutyl benzyl
 2-propyl benzyl 871 benzyl NHC(O)NH cyclobutyl benzyl 2-propyl benzyl
 872 benzyl NHC(O)NH cyclobutyl- benzyl 2-propyl benzyl    methyl 873
 benzyl NHC(O)NH cyclopentyl- benzyl 2-propyl benzyl    methyl 874 benzyl
 NHC(O)NH cyclopropyl benzyl 2-propyl benzyl 875 benzyl NHC(O)NH cycloprop
 yl- benzyl 2-propyl benzyl    methyl 876 cis-2-deca- NHC(O)NH2-butyl
 benzyl 2-propyl benzyl  hydronaphthylmethyl 877 cis-2-deca- NHC(O)NH
 2-butyl benzyl 2-propyl benzyl  hydronaphthylmethyl 878 benzyl O
 2-propyl benzyl 2-propyl benzyl 879 (CH.sub.2 CH.sub.2 CH)CH.sub.2
 CH.sub.2 OC(O)NH 2-butyl benzyl 2-propyl benzyl 880 1-piperidylethyl
 OC(O)NH 2-butyl benzyl 2-propyl benzyl 881 2-benzimidazolyl- OC(O)NH
 2-butyl benzyl 2-propyl benzyl  methyl 882 2-naphthylmethyl OC(O)NH
 2-butyl benzyl 2-propyl benzyl 883 2-pyridylmethyl OC(O)NH 2-butyl
 benzyl 2-propyl benzyl 884 2-quinazolinyl- OC(O)NH 2-butyl benzyl
 2-propyl benzyl  methyl 885 3,4-methylene- OC(O)NH 2-butyl benzyl
 2-propyl benzyl  dioxyphenylmethyl 886 3-chlorobenzyl OC(O)NH 2-butyl
 benzyl cyclobutylbenzyl 887 3-phenylpropyl OC(O)NH 2-butyl benzyl
 cyclobutyl- (CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2)      methyl
 888 4&#39;-acetamido- OC(O)NH 2-butyl benzyl cyclopropyl (CH.sub.2 CH.sub.2
 OCH.sub.2 CH.sub.2)  benzyl 889 4-imidazolyl- OC(O)NH 2-butyl benzyl
 2-propyl 2-hydroxy-  methyl     indanylmethyl 890 4-methane- OC(O)NH
 2-butyl benzyl 2-propyl 3,5-dimethoxy-  sulfonylbenzyl     phenyl 891
 4-methoxybenzyl OC(O)NH 2-butyl benzyl 2-propyl 3-hydroxy-
 n-propyl 892 4-pyridylmethyl OC(O)NH 2-butyl benzyl 2-propyl 4&#39;-nitro-
     benzyl 893 4-trifluoro- OC(O)NH 2-butyl benzyl 2-propyl 4-benzyl-
 methylbenzyl     oxyphenylmethyl 894 9-fluorenyl- OC(O)NH 2-butyl benzyl
 2-propyl 4-cyano-n-  methyl     butyl 895 adamantylmethyl OC(O)NH
 2-butyl benzyl 2-propyl 4-phenoxy-       phenylmethyl 896 benzyl OC(O)NH
 1-methoxy-2- benzyl 2-propyl 4-t-butyl-    propyl   phenylmethyl 897
 benzyl OC(O)NH 2&#39;-hydroxy- benzyl 2-propyl adamantyl    cyclopentylmethyl
  989 benzyl OC(O)NH 2,2,2-trichlor- benzyl 2-propyl benzyl    oethyl 899
 benzyl OC(O)NH 2,2,2-trifluor- benzyl 2-butyl benzyl    oethyl 900
 benzyl OC(O)NH 2-butyl benzyl 2-butyl benzyl 901 benzyl OC(O)NH 2-propylb
 enzyl 2-propyl benzyl 902 benzyl OC(O)NH 2-propylbenzyl 2-propyl benzyl
 903 benzyl OC(O)NH 2-propyl3-naphth- 2-butyl benzyl  ylmethyl 904 benzyl
 OC(O)NH 2-propyl4&#39;-phenoxy- 2-butyl benzyl  benzyl 905 benzyl OC(O)NH
 2-propyl4&#39;-benzyl- 2-butyl benzyl  oxybenzyl 906 benzyl OC(O)NH 2-propyl4
 &#39;-(5-tetra- 2-butyl benzyl  zolyl)benzyl 907 benzyl OC(O)NH 2-propyl
 3&#39;,5&#39;-bis(tri- 2-butyl benzyl  fluoremethyl)-  benzyl 908 benzyl OC(O)NH
 2-propyl 4&#39;-trifluoro- 2-butyl benzyl  methylbenzyl 909 benzyl OC(O)NH
 2-propyl 2-phenylethyl 2-butyl benzyl 910 benzyl OC(O)NH 2-propyl
 2-benzimi- 2-butyl benzyl  dazolylmethyl 911 benzyl OC(O)NH 2-propyl
 2-(4-chloro- 2-butyl benzyl  phenyl)ethyl 912 benzyl OC(O)NH 2-propyl
 2-decahydro- 2-butyl benzyl  naphthylmethyl 913 benzyl OC(O)NH 2-propyl
 2-(3,4-methylene- 2-butyl benzyl  dioxyphenyl)ethyl 914 benzyl OC( O)NH
 3-(dimethyl- benzyl 2-butyl benzyl    amino)-1-propyl 915 benzyl OC(O)NH
 benzyl benzyl 2-butyl benzyl 916 benzyl OC(O)NH CH.sub.2
  NHC(O)NHCH.sub.3 benzyl 2-propyl benzyl 917 benzyl OC(O)NH CH.sub.2
 NHSO.sub.2 CH.sub.3 benzyl 2-propyl benzyl 918 benzyl OC(O)NH cyclobutyl
 benzyl 2-propyl benzyl 919 benzyl OC(O)NH cyclobutyl- benzyl 2-propyl
 benzyl    methyl 920 benzyl OC(O)NH cyclopropyl benzyl 2-propyl benzyl
 921 benzyl OC(O)NH cyclopropyl- benzyl 2-propyl benzyl    methyl 922
 benzyl OC(O)NH methyl benzyl 2-propyl cis-2-deca-       hydronaphthyl-
     methyl 923 CH.sub.3 SO.sub.2 CH.sub.2 CH.sub.2 OC(O)NH 2-butyl
 benzyl 2-propyl cis-2-deca-       hydronaphthyl-       methyl 924
 cyclopentylethyl OC(O)NH 2-butyl benzyl 2-propyl benzyl 925 F.sub.2
 HCOC.sub.6 H.sub.4 CH.sub.2 OC(O)NH 2-butyl benzyl 2-propyl (CH.sub.2
 CH.sub.2 CH)CH.sub.2 CH.sub.2 926 benzyl OCH.sub.2 2-propyl benzyl
 2-propyl 1-piperidyl-       ethyl 927 benzyl OP(O)(OMe)O 2-propyl benzyl
 benzyl 2-benzimidazolyl-       methyl 928 benzyl SO.sub.2 2-propyl
 benzyl CH.sub. 2 CF.sub.3 2-naphthyl-       methyl 930 2,4-difluoro-
 SO.sub.2 NH 2-butyl benzyl CH.sub.2 CH.sub.2 C(O)NH.sub.2 2-pyridyl
 phenyl     methyl 931 4&#39;-methylphenyl SO.sub.2 NH 2-butyl benzyl
 CH.sub.2 CH.sub.2 OH 2-quinazolinyl-       methyl 932 benzyl SO.sub.2 NH
 2-(methyl- benzyl CH.sub.2 CHOHCH.sub.3 3,4-methylene-    amino)ethyl
 dioxyphenylmethyl 933 benzyl SO.sub.2
  NH 2-furanylmethyl benzyl cyclobutyl 3-chlorobenzyl 934 benzyl SO.sub.2
 NH 2-propyl benzyl cyclobutyl 3-phenylpropyl 936 benzyl SO.sub.2 NH
 2-propyl benzyl cyclobutylmethyl 4&#39;-acetamidobenzyl 937 benzyl SO.sub.2
 NH 2-propyl 3&#39;-trifluoro- cyclopentylmethyl 4-imidazolyl-     methylbenzy
 l  methyl 938 benzyl SO.sub.2 NH 2-propyl 2&#39;,4&#39;-difluoro- cyclopropyl
 4-methanesulfonyl-     benzyl  benzyl 939 benzyl SO.sub.2 NH 2-propyl
 3-phenyl- cyclopentylmethyl 4-methoxy-     phenylpropyl  benzyl 940
 benzyl SO.sub.2 NH 2-propyl 1-pyrrolyl- 2-butyl 4-pyridyl-     ethyl
 methyl 941 benzyl SO.sub.2 NH 2-propyl 2-(4-chloro- 2-butyl 4-trifluoro-
     phenyl)ethyl  methylbenzyl 942 benzyl SO.sub.2
  NH 2-propyl 1-phenylethyl 2-propyl 9-fluoroenyl-       methyl 943
 benzyl SO.sub.2 NH 3-hydroxy-1- 1-phenylethyl 2-butyl adamantyl-
 propyl   methyl 944 benzyl SO.sub.2 NH cyclobutyl benzyl 2-butyl benzyl
 945 benzyl SO.sub.2 NH cyclopropyl benzyl 2-butyl benzyl 946 benzyl
 SO.sub.2
  NH methylthiomethyl 1-phenylethyl 2-butyl benzyl 947 cyclohexylethyl
 SO.sub.2 NH 2-butyl benzyl 2-butyl benzyl 948 nonafluorobutyl SO.sub.2
 NH 2-butyl benzyl 2-butyl benzyl 949 phenyl SO.sub.2 NH 2-butyl benzyl
 2-butyl benzyl 950 trifluoromethyl SO.sub.2 NH 2-butyl benzyl 2-butyl
 benzyl 951 2,4-difluoro- SO.sub.2 NHC(O)NH2-butyl benzyl 2-butyl benzyl
 phenyl 952 4&#39;-methylphenyl SO.sub.2 NHC(O)NH2-(dimethyl- benzyl 2-butyl
 benzyl    amino)ethyl 953 4&#39;-methylphenyl SO.sub.2 NHC(O)NH2-butyl
 benzyl 2-butyl benzyl 954 4&#39;-methylphenyl SO.sub.2 NHC(O)NH2-butyl
 benzyl 2-butyl benzyl 955 4&#39;-methylphenyl SO.sub.2 NHC(O)NHbenzyl benzyl
 2-butyl benzyl 956 4&#39;-methylphenyl SO.sub.2 NHC(O)NHCH.sub.2 CH.sub.2 OH
 benzyl 2-butyl benzyl 957 4&#39;-methylphenyl SO.sub.2 NHC(O)NHcyclobutyl
 benzyl 2-butyl benzyl 958 4&#39;-methylphenyl SO.sub.2
  NHC(O)NHcyclohexylmethyl benzyl 2-butyl benzyl 959 4&#39;-methylphenyl
 SO.sub.2 NHC(O)NHcyclopropyl benzyl 2-butyl benzyl 960 benzyl SO.sub.2
 NHC(O)NH2-butyl benzyl 1-methoxy-2- benzyl      propyl 961 cyclohexylethy
 l SO.sub.2
  NHC(O)NH2-butyl benzyl 2&#39;-hydroxy- benzyl      cyclopentylmethyl 962
 methyl SO.sub.2
  NHC(O)NH2-butyl benzyl 2,2,2-tri- benzyl      chloroethyl 963 nonafluoro
 butyl SO.sub.2
  NHC(O)NH 2-butyl benzyl 2,2,2-tri- benzyl      fluoroethyl 964 phenyl
 SO.sub.2 NHC(O)NH 2-butyl benzyl 2-butyl benzyl 965 phenyl SO.sub.2
 NHC(O)NH 2-butyl benzyl 2-propyl benzyl 966 phenyl SO.sub.2 NHC(O)NH
 2-butyl 2&#39;-chloro- 2-propyl benzyl     benzyl 967 phenyl SO.sub.2
 NHC(O)NH 2-butyl 3-naphthyl- 2-propyl benzyl     methyl 968 phenyl
 SO.sub.2 NHC(O)NH 2-butyl 2-(4-fluoro- 2-propyl benzyl     phenyl)ethyl
 969 phenyl SO.sub.2 NHC(O)NH 2-butyl 2-phenylethyl 2-propyl benzyl 970
 phenyl SO.sub.2
  NHC(O)NH 2-butyl 3&#39;-carbo- 2-propyl benzyl     methoxybenzyl 971 phenyl
 SO.sub.2 NHC(O)NH 2-butyl benzyl 2-propyl CH.sub.3 SO.sub.2 CH.sub.2
 CH.sub.2 972 phenyl SO.sub.2 NHC(O)NH cyclopropyl benzyl 2-propyl
 cyclophenyl       ethyl 973 trifluoromethyl SO.sub.2 NHC(O)NH 2-butyl
 benzyl 2-propyl F.sub.2 HCOC.sub.6 H.sub.4 CH.sub.2 974 trifluoromethyl
 SO.sub.2 NHC(O)NH 2-butyl benzyl 2-propyl benzyl 975 trifluoromethyl
 SO.sub.2 NHC(O)NH cyclobutyl benzyl 2-propyl benzyl 976 trifluoromethyl
 SO.sub.2
  NHC(O)NH cyclopropyl benzyl 2-propyl benzyl
 
    
     
                                           TABLE XVI                               
__________________________________________________________________________
 ##STR187##                                                               
Ex.                                                                       
No.                                                                       
   R.sup.1         W         R.sup.3       R.sup.4       R.sup.8          
__________________________________________________________________________
 977                                                                      
   2-pyridylethyl  C(O)      2-propyl      benzyl        t-butyl          
 978                                                                      
   2-pyridylmethyl C(O)      2-butyl       4-imidazolylmethyl             
                                                         t-butyl          
 979                                                                      
   benzyl          C(O)      2-butyl       cyclohexylmethyl               
                                                         t-butyl          
 980                                                                      
   2-pyridyl-methyl                                                       
                   C(O)      2-propyl      benzyl        t-butyl          
 981                                                                      
   benzyl          C(O)      2-propyl      2-pyridyl-methyl               
                                                         t-butyl          
 982                                                                      
   3-pyridyl-methyl                                                       
                   C(O)      2-propyl      benzyl        t-butyl          
 983                                                                      
   n-propyl        C(O)      2-propyl      benzyl        t-butyl          
 984                                                                      
   naphthyl        C(O)      2-propyl      3-pyridyl-methyl               
                                                         t-butyl          
 985                                                                      
   phenyl          C(O)      2-propyl      benzyl        t-butyl          
 986                                                                      
   thiophenyl      C(O)      2-propyl      benzyl        t-butyl          
 987                                                                      
   trifluoromethyl C(O)      2-propyl      3-pyridyl-methyl               
                                                         t-butyl          
 988                                                                      
   benzyl          C(O)CH.sub.2                                           
                             2-propyl      benzyl        t-butyl          
 989                                                                      
   2-pyridylmethyl C(O)NH    2-butyl       2-pyridyl-methyl               
                                                         t-butyl          
 990                                                                      
   benzyl          C(O)NH    2-butyl       3-pyridyl-methyl               
                                                         t-butyl          
 991                                                                      
   benzyl          C(O)NH    2-butyl       benzyl        t-butyl          
 992                                                                      
   benzyl          C(O)NH    cyclobutyl    benzyl        t-butyl          
 993                                                                      
   benzyl          C(O)NH    cyclobutylmethyl                             
                                           benzyl        t-butyl          
 994                                                                      
   methyl          C(O)NH    2-butyl       3-pyridyl-methyl               
                                                         t-butyl          
 995                                                                      
   phenylethyl     C(O)NH    2-butyl       benzyl        t-butyl          
 996                                                                      
   benzyl          C(O)NHNH  2-propyl      3-pyridyl-methyl               
                                                         t-butyl          
 997                                                                      
   benzyl          C(O)O     2-propyl      benzyl        t-butyl          
 998                                                                      
   benzyl          C(S)      2-propyl      benzyl        t-butyl          
 999                                                                      
   benzyl          C(S)NH    2-propyl      3-pyridyl-methyl               
                                                         t-butyl          
1000                                                                      
   benzyl          C(Cl)N    2-propyl      benzyl        t-butyl          
1001                                                                      
   2-pyridylmethyl C(NHMe)N  2-propyl      benzyl        t-butyl          
1002                                                                      
   3-methylpropyl  C(NHMe)N  2-propyl      benzyl        t-butyl          
1003                                                                      
   benzyl          C(NHMe)N  2-propyl      benzyl        t-butyl          
1004                                                                      
   benzyl          C(NHMe)N  2-propyl      3-pyridyl-methyl               
                                                         t-butyl          
1005                                                                      
   2-pyridylethyl  C(OCH.sub.2 CH.sub.2)N                                 
                             2-propyl      benzyl        t-butyl          
1006                                                                      
   3-naphthylmethyl                                                       
                   C(OCH.sub.2 CH.sub.2)N                                 
                             2-propyl      benzyl        t-butyl          
1007                                                                      
   4&#39;-t-butylbenzyl                                                       
                   C(OCH.sub.2 CH.sub.2)N                                 
                             2-propyl      3-pyridyl-methyl               
                                                         t-butyl          
1008                                                                      
   benzyl          C(OCH.sub.2 CH.sub.2)N                                 
                             2-propyl      benzyl        t-butyl          
1009                                                                      
   benzyl          C(OCH.sub.2 CH.sub.2)N                                 
                             2-propyl      4&#39;-ytrifluoromethylbenzyl      
                                                         t-butyl          
1010                                                                      
   benzyl          C(OCH.sub.2 CH.sub.2)N                                 
                             2-propyl      4&#39;-chlorobenzyl                
                                                         t-butyl          
1011                                                                      
   benzyl          C(OCH.sub.2 CH.sub.2)N                                 
                             2-propyl      cyclohexylmethyl               
                                                         t-butyl          
1012                                                                      
   benzyl          C(OCH.sub.2 CH.sub. 2)N                                
                             cyclobutyl    benzyl        t-butyl          
1013                                                                      
   benzyl          C(OCH.sub.2 CH.sub.2)N                                 
                             cyclobutylmethyl                             
                                           3-pyridyl-methyl               
                                                         t-butyl          
1014                                                                      
   benzyl          C(OCH.sub.2 CH.sub.2)N                                 
                             cyclopropyl   benzyl        t-butyl          
1015                                                                      
   benzyl          C(OCH.sub.2)N                                          
                             2-propyl      benzyl        t-butyl          
1016                                                                      
   benzyl          CH.sub.2 OCH.sub.2                                     
                             2-propyl      3-pyridyl-methyl               
                                                         t-butyl          
1017                                                                      
   benzyl          CH.sub.2 CH.sub.2                                      
                             2-propyl      benzyl        t-butyl          
1018                                                                      
   benzyl          CH.sub.2 CHOH                                          
                             2-propyl      4-pyridyl-methyl               
                                                         t-butyl          
1019                                                                      
   benzyl          CH.sub.2 O                                             
                             2-propyl      benzyl        t-butyl          
1020                                                                      
   benzyl          CH.sub.2 OH                                            
                             2-propyl      2-pyridyl-methyl               
                                                         t-butyl          
1021                                                                      
   benzyl          CHCH      2-propyl      benzyl        t-butyl          
1022                                                                      
   benzyl          CHOHCH.sub.2                                           
                             2-propyl      3-pyridyl-methyl               
                                                         t-butyl          
1023                                                                      
   benzyl          CHOHCHOH  2-propyl      benzyl        t-butyl          
1024                                                                      
   benzyl          HNC(S)NH  2-propyl      4-pyridyl-methyl               
                                                         t-butyl          
1025                                                                      
   benzyl          HNSO.sub.2                                             
                             2-butyl       benzyl        t-butyl          
1026                                                                      
   benzyl          HNSO.sub.2 NH                                          
                             2-butyl       benzyl        t-butyl          
1027                                                                      
   benzyl          NN        2-propyl      benzyl        t-butyl          
1028                                                                      
   benzyl          NHNH      2-propyl      4-pyridyl-methyl               
                                                         t-butyl          
1029                                                                      
   (CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 CH.sub.2 )                        
                   NHC(O)NH  2-butyl       benzyl        t-butyl          
1030                                                                      
   (CH.sub.2 CH.sub.2 OCH.sub.2 CH.sub.2 )                                
                   NHC(O)NH  2-butyl       4-pyridyl-methyl               
                                                         t-butyl          
1031                                                                      
   2-hydroxyindanyl-methyl                                                
                   NHC(O)NH  2-butyl       benzyl        t-butyl          
1032                                                                      
   3,5-dimethoxyphenyl                                                    
                   NHC(O)NH  2-butyl       4-pyridyl-methyl               
                                                         t-butyl          
1033                                                                      
   3-hydroxy-n-propyl                                                     
                   NHC(O)NH  2-butyl       benzyl        t-butyl          
1034                                                                      
   4&#39;-nitrobenzyl  NHC(O)NH  2-butyl       benzyl        t-butyl          
1035                                                                      
   4-benzyloxyphenylmethyl                                                
                   NHC(O)NH  2-butyl       4-pyridyl-methyl               
                                                         t-butyl          
1036                                                                      
   4-cyano-n-butyl NHC(O)NH  2-butyl       benzyl        t-butyl          
1037                                                                      
   4-phenoxyphenyl-methyl                                                 
                   NHC(O)NH  2-butyl       benzyl        t-butyl          
1038                                                                      
   4-t-butylphenyl-methyl                                                 
                   NHC(O)NH  2-butyl       benzyl        t-butyl          
1039                                                                      
   adamantyl       NHC(O)NH  2-butyl       benzyl        t-butyl          
1040                                                                      
   benzyl          NHC(O)NH  2-butyl       4-pyridyl-methyl               
                                                         t-butyl          
1041                                                                      
   benzyl          NHC(O)NH  2-butyl       benzyl        t-butyl          
1042                                                                      
   benzyl          NHC(O)NH  2-propyl      3-pyridyl-methyl               
                                                         t-butyl          
1043                                                                      
   benzyl          NHC(O)NH  2-propyl      2-naphthylmethyl               
                                                         t-butyl          
1044                                                                      
   benzyl          NHC(O)NH  2-propyl      3-naphthylmethyl               
                                                         t-butyl          
1045                                                                      
   benzyl          NHC(O)NH  2-propyl      1-adamantylmethul              
                                                         t-butyl          
1046                                                                      
   benzyl          NHC(O)NH  2-propyl      4&#39;-hydroxybenzyl               
                                                         2-propyl         
1047                                                                      
   benzyl          NHC(O)NH  2-propyl      2-imidazolylethyl              
                                                         2-propyl         
1048                                                                      
   benzyl          NHC(O)NH  2-propyl      4-pyridinylmethyl              
                                                         2-propyl         
1049                                                                      
   benzyl          NHC(O)NH  2-propyl      4-bromophenyl 2-propyl         
1050                                                                      
   benzyl          NHC(O)NH  2-propyl      cycloheptylmethyl              
                                                         2-propyl         
1051                                                                      
   benzyl          NHC(O)NH  2-propyl      2-thiophenylmethyl             
                                                         2-propyl         
1052                                                                      
   benzyl          NHC(O)NH  2-propyl      3-pyrrazolylmethyl             
                                                         2-propyl         
1053                                                                      
   benzyl          NHC(O)NH  benzyl        benzyl                         
1054                                                                      
   benzyl          NHC(O)NH  CH.sub.2 CF.sub.3                            
                                           benzyl        2-propyl         
1055                                                                      
   benzyl          NHC(O)NH  CH.sub.2 CH.sub.2 C(O)NH.sub.2               
                                           benzyl        2-propyl         
1056                                                                      
   benzyl          NHC(O)NH  CH.sub.2 CH.sub.2 OH                         
                                           benzyl        2-propyl         
1057                                                                      
   benzyl          NHC(O)NH  CH.sub.2 CHOHCH.sub.2                        
                                           benzyl        2-propyl         
1058                                                                      
   benzyl          NHC(O)NH  cyclobutyl    4-pyridyl-methyl               
                                                         2-propyl         
1059                                                                      
   benzyl          NHC(O)NH  cyclobutyl    benzyl        2-propyl         
1060                                                                      
   benzyl          NHC(O)NH  cyclobutylmethyl                             
                                           benzyl        2-propyl         
1061                                                                      
   benzyl          NHC(O)NH  cyclopentylmethyl                            
                                           3-pyridyl-methyl               
                                                         2-propyl         
1062                                                                      
   benzyl          NHC(O)NH  cyclopropyl   benzyl        2-propyl         
1063                                                                      
   benzyl          NHC(O)NH  cyclopropylmethyl                            
                                           benzyl        2-propyl         
1064                                                                      
   cis-2-decahydronaphthylmethyl                                          
                   NHC(O)NH  2-butyl       3-pyridyl-methyl               
                                                         2-propyl         
1065                                                                      
   cis-2-decahydronaphthylmethyl                                          
                   NHC(O)NH  2-butyl       benzyl        2-propyl         
1066                                                                      
   benzyl          O         2-propyl      benzyl        2-propyl         
1067                                                                      
   (CH.sub.2 CH.sub.2 CH)CH.sub.2 CH.sub.2                                
                   OC(O)NH   2-butyl       3-pyridyl-methyl               
                                                         2-propyl         
1068                                                                      
   1-piperidylethyl                                                       
                   OC(O)NH   2-butyl       benzyl        2-propyl         
1069                                                                      
   2-benzimidazolylmethyl                                                 
                   OC(O)NH   2-butyl       benzyl        2-propyl         
1070                                                                      
   2-naphthylmethyl                                                       
                   OC(O)NH   2-butyl       benzyl        2-propyl         
1071                                                                      
   2-pyridylmethyl OC(O)NH   2-butyl       3-pyridyl-methyl               
                                                         2-propyl         
1072                                                                      
   2-quinazolinylmethyl                                                   
                   OC(O)NH   2-butyl       benzyl        2-propyl         
1073                                                                      
   3,4-methylenedioxyphenylmethyl                                         
                   OC(O)NH   2-butyl       benzyl        2-propyl         
1074                                                                      
   3-chlorobenzyl  OC(O)NH   2-butyl       benzyl        2-propyl         
1075                                                                      
   3-phenylpropyl  OC(O)NH   2-butyl       3-pyridyl-methyl               
                                                         2-propyl         
1076                                                                      
   4&#39;-acetamidobenzyl                                                     
                   OC(O)NH   2-butyl       benzyl        2-propyl         
1077                                                                      
   4-imidazolylmethyl                                                     
                   OC(O)NH   2-butyl       benzyl        2-propyl         
1078                                                                      
   4-methanesulfonylbenzyl                                                
                   OC(O)NH   2-butyl       benzyl        2-propyl         
1079                                                                      
   4-methoxybenzyl OC(O)NH   2-butyl       benzyl        2-propyl         
1080                                                                      
   4-pyridylmethyl OC(O)NH   2-butyl       benzyl        2-propyl         
1081                                                                      
   4-trifluoromethylbenzyl                                                
                   OC(O)NH   2-butyl       benzyl        2-propyl         
1082                                                                      
   9-fluorenylmethyl                                                      
                   OC(O)NH   2-butyl       benzyl        2-propyl         
1083                                                                      
   adamantylmethyl OC(O)NH   2-butyl       benzyl        iso-butyl        
1084                                                                      
   benzyl          OC(O)NH   1-methoxy-2-propyl                           
                                           benzyl        iso-butyl        
1085                                                                      
   benzyl          OC(O)NH   2&#39;-hydroxycyclopentylmethyl                  
                                           benzyl        iso-butyl        
1086                                                                      
   benzyl          OC(O)NH   2,2,2-trichloroethyl                         
                                           benzyl        iso-butyl        
1087                                                                      
   benzyl          OC(O)NH   2,2,2-trifluoroethyl                         
                                           benzyl        iso-butyl        
1088                                                                      
   benzyl          OC(O)NH   2-butyl       benzyl        iso-butyl        
1089                                                                      
   benzyl          OC(O)NH   2-propyl      3-pyridyl-methyl               
                                                         iso-butyl        
1090                                                                      
   3-pyridyl-methyl                                                       
                   OC(O)NH   2-propyl      benzyl        iso-butyl        
1091                                                                      
   3-pyridyl-methyl                                                       
                   OC(O)NH   2-propyl      3-naphthylmethyl               
                                                         iso-butyl        
1092                                                                      
   benzyl          OC(O)NH   2-propyl      4&#39;-phenoxybenzyl               
                                                         iso-butyl        
1093                                                                      
   benzyl          OC(O)NH   2-propyl      4&#39;-benzyloxybenzyl             
                                                         iso-butyl        
1094                                                                      
   benzyl          OC(O)NH   2-propyl      4&#39;-(5-tetrazolyl)benzyl        
                                                         iso-butyl        
1095                                                                      
   benzyl          OC(O)NH   2-propyl      3&#39;,5&#39;-        iso-butyl        
                                           bis(trifluoremethyl)benzyl     
1096                                                                      
   benzyl          OC(O)NH   2-propyl      4&#39;-trifluoromethylbenzyl       
                                                         iso-butyl        
1097                                                                      
   benzyl          OC(O)NH   2-propyl      2-phenylethyl iso-butyl        
1098                                                                      
   benzyl          OC(O)NH   2-propyl      2-benzimidazolylmethyl         
                                                         iso-butyl        
1099                                                                      
   benzyl          OC(O)NH   2-propyl      2-(4-chlorophenyl)ethyl        
                                                         iso-butyl        
1100                                                                      
   benzyl          OC(O)NH   2-propyl      2-decahydronaphthylmethyl      
                                                         iso-butyl        
1101                                                                      
   benzyl          OC(O)NH   2-propyl      2-(3,4-       iso-butyl        
                                           methylenedioxyphenyl)ethyl     
1102                                                                      
   benzyl          OC(O)NH   3-(dimethylamino)-                           
                                           benzyl        iso-butyl        
                             1-propyl                                     
1103                                                                      
   benzyl          OC(O)NH   benzyl        benzyl        iso-butyl        
1104                                                                      
   benzyl          OC(O)NH   CH.sub.2 NHC(O)NHCH.sub.2                    
                                           3-pyridyl-methyl               
                                                         iso-butyl        
1105                                                                      
   benzyl          OC(O)NH   CH.sub.2 NHSO.sub.2 CH.sub.2                 
                                           benzyl        iso-butyl        
1106                                                                      
   benzyl          OC(O)NH   cyclobutyl    3-pyridyl-methyl               
                                                         iso-butyl        
1107                                                                      
   benzyl          OC(O)NH   cyclobutylmethyl                             
                                           benzyl        iso-butyl        
1108                                                                      
   benzyl          OC(O)NH   cyclopropyl   benzyl        iso-butyl        
1109                                                                      
   benzyl          OC(O)NH   cyclopropylmethyl                            
                                           3-pyridyl-methyl               
                                                         iso-butyl        
1110                                                                      
   benzyl          OC(O)NH   methyl        benzyl        iso-butyl        
1111                                                                      
   CH.sub.2 SO.sub.2 CH.sub.2 CH.sub.2                                    
                   OC(O)NH   2-butyl       3-pyridyl-methyl               
                                                         iso-butyl        
1112                                                                      
   cyclopentylethyl                                                       
                   OC(O)NH   2-butyl       benzyl        iso-butyl        
1113                                                                      
   F2HCOC6H4CH.sub.2                                                      
                   OC(O)NH   2-butyl       3-pyridyl-methyl               
                                                         iso-butyl        
1114                                                                      
   benzyl          OCH.sub.2 2-propyl      benzyl        iso-butyl        
1115                                                                      
   benzyl          OP(O)(OMe)O                                            
                             2-propyl      3-pyridyl-methyl               
                                                         iso-butyl        
1116                                                                      
   benzyl          SO.sub.2  2-propyl      benzyl        iso-butyl        
1117                                                                      
   2,4-difluorophenyl                                                     
                   SO.sub.2 NH                                            
                             2-butyl       benzyl        iso-butyl        
1118                                                                      
   4&#39;-methylphenyl SO.sub.2 NH                                            
                             2-butyl       benzyl        iso-butyl        
1119                                                                      
   benzyl          SO.sub.2 NH                                            
                             2-(methylamino)ethyl                         
                                           benzyl        iso-butyl        
1120                                                                      
   benzyl          SO.sub.2 NH                                            
                             2-furanylmethyl                              
                                           benzyl        iso-butyl        
1121                                                                      
   3-pyridyl-methyl                                                       
                   SO.sub.2 NH                                            
                             2-propyl      3-pyridyl-methyl               
                                                         iso-butyl        
1122                                                                      
   benzyl          SO.sub.2 NH                                            
                             2-propyl      benzyl        t-butyl          
1123                                                                      
   3-pyridyl-methyl                                                       
                   SO.sub.2 NH                                            
                             2-propyl      3&#39;-trifluoromethylbenzyl       
1124                                                                      
   benzyl          SO.sub.2 NH                                            
                             2-propyl      2&#39;,4&#39;-difluorobenzyl           
                                                         t-butyl          
1125                                                                      
   benzyl          SO.sub.2 NH                                            
                             2-propyl      3-phenylpropyl                 
                                                         t-butyl          
1126                                                                      
   benzyl          SO.sub.2 NH                                            
                             2-propyl      1-pyrrolylethyl                
                                                         t-butyl          
1127                                                                      
   2-pyridyl-methyl                                                       
                   SO.sub.2 NH                                            
                             2-propyl      2-(4-chlorophenyl)ethyl        
                                                         t-butyl          
1128                                                                      
   benzyl          SO.sub.2 NH                                            
                             2-propyl      1-phenylethyl t-butyl          
1129                                                                      
   3-pyridyl-methyl                                                       
                   SO.sub.2 NH                                            
                             3-hydroxy-1-propyl                           
                                           1-phenylethyl t-butyl          
1130                                                                      
   benzyl          SO.sub.2 NH                                            
                             cyclobutyl    benzyl        t-butyl          
1131                                                                      
   benzyl          SO.sub.2 NH                                            
                             cyclopropyl   benzyl        t-butyl          
1132                                                                      
   benzyl          SO.sub.2 NH                                            
                             methylthiomethyl                             
                                           1-phenylethyl t-butyl          
1133                                                                      
   2-pyridyl-methyl                                                       
                   SO.sub.2 NH                                            
                             2-butyl       benzyl        t-butyl          
1134                                                                      
   nonafluorobutyl SO.sub.2 NH                                            
                             2-butyl       benzyl        t-butyl          
1135                                                                      
   phenyl          SO.sub.2 NH                                            
                             2-butyl       benzyl        t-butyl          
1136                                                                      
   trifluoromethyl SO.sub.2 NH                                            
                             2-butyl       benzyl        t-butyl          
1137                                                                      
   2,4-difluorophenyl                                                     
                   SO.sub.2 NHC(O)NH                                      
                             2-butyl       benzyl        t-butyl          
1138                                                                      
   4&#39;-methylphenyl SO.sub.2 NHC(O)NH                                      
                             2-(dimethylamino)ethyl                       
                                           benzyl        t-butyl          
1139                                                                      
   4&#39;-methylphenyl SO.sub.2 NHC(O)NH                                      
                             2-butyl       2-pyridyl-methyl               
                                                         t-butyl          
1140                                                                      
   4&#39;-methylphenyl SO.sub.2 NHC(O)NH                                      
                             2-butyl       benzyl        t-butyl          
1141                                                                      
   4&#39;-methylphenyl SO.sub.2 NHC(O)NH                                      
                             benzyl        2-pyridyl-methyl               
                                                         t-butyl          
1142                                                                      
   4&#39;-methylphenyl SO.sub.2 NHC(O)NH                                      
                             CH.sub.2 CH.sub.2 OH                         
                                           benzyl        t-butyl          
1143                                                                      
   4&#39;-methylphenyl SO.sub.2 NHC(O)NH                                      
                             cyclobutyl    benzyl        t-butyl          
1144                                                                      
   4&#39;-methylphenyl SO.sub.2 NHC(O)NH                                      
                             cyclohexylmethyl                             
                                           benzyl        t-butyl          
1145                                                                      
   4&#39;-methylphenyl SO.sub.2 NHC(O)NH                                      
                             cyclopropyl   2-pyridyl-methyl               
                                                         t-butyl          
1146                                                                      
   benzyl          SO.sub.2 NHC(O)NH                                      
                             2-butyl       benzyl        t-butyl          
1147                                                                      
   cyclohexylethyl SO.sub.2 NHC(O)NH                                      
                             2-butyl       benzyl        t-butyl          
1148                                                                      
   methyl          SO.sub.2 NHC(O)NH                                      
                             2-butyl       benzyl        t-butyl          
1149                                                                      
   nonafluorobutyl SO.sub.2 NHC(O)NH                                      
                             2-butyl       2-pyridyl-methyl               
                                                         t-butyl          
1150                                                                      
   phenyl          SO.sub.2 NHC(O)NH                                      
                             2-butyl       benzyl        t-butyl          
1151                                                                      
   phenyl          SO.sub.2 NHC(O)NH                                      
                             2-butyl       benzyl        t-butyl          
1152                                                                      
   phenyl          SO.sub.2 NHC(O)NH                                      
                             2-butyl       2&#39;-chlorobenzyl                
                                                         t-butyl          
1153                                                                      
   phenyl          SO.sub.2 NHC(O)NH                                      
                             2-butyl       3-naphthylmethyl               
                                                         t-butyl          
1154                                                                      
   phenyl          SO.sub.2 NHC(O)NH                                      
                             2-butyl       2-(4-fluorophenyl)ethyl        
                                                         t-butyl          
1155                                                                      
   phenyl          SO.sub.2 NHC(O)NH                                      
                             2-butyl       2-phenylethyl t-butyl          
1156                                                                      
   phenyl          SO.sub.2 NHC(O)NH                                      
                             2-butyl       3&#39;-carbomethoxybenzyl          
                                                         t-butyl          
1157                                                                      
   phenyl          SO.sub.2 NHC(O)NH                                      
                             2-butyl       benzyl        t-butyl          
1158                                                                      
   phenyl          SO.sub.2 NHC(O)NH                                      
                             cyclopropyl   2-pyridyl-methyl               
                                                         t-butyl          
1159                                                                      
   trifluoromethyl SO.sub.2 NHC(O)NH                                      
                             2-butyl       benzyl        t-butyl          
1160                                                                      
   trifluoromethyl SO.sub.2 NHC(O)NH                                      
                             2-butyl       benzyl        t-butyl          
1161                                                                      
   trifuloromethyl SO.sub.2 NHC(O)NH                                      
                             cyclobutyl    2-pyridyl-methyl               
                                                         t-butyl          
1162                                                                      
   trifluoromethyl SO.sub.2 NHC(O)NH                                      
                             cyclopropyl   benzyl        t-butyl          
1163                                                                      
   Benzimidazolylmethyl                                                   
                   N(CH.sub.2)C(O)NH                                      
                             2-propyl      4-pyridyl-methyl               
                                                         t-butyl          
1164                                                                      
   Benzimidazolylmethyl                                                   
                   NC(O)NH   2-propyl      4-pyridyl-methyl               
                                                         t-butyl          
1165                                                                      
   (CH.sub.2)2NCH(CH.sub.2)                                               
                   C(O)NH    2-propyl      4-fluoro-benzyl                
                                                         t-butyl          
1166                                                                      
   2-amino-2-propyl                                                       
                   C(O)NH    CF.sub.3      benzyl        t-butyl          
1167                                                                      
   dimethylaminomethyl                                                    
                   C(O)NH    2-propyl      benzyl        t-butyl          
1168                                                                      
   dimethylaminomethyl                                                    
                   C(O)NH    2-propyl      benzyl        t-propyl         
1169                                                                      
   4-amino-benzyl  C(O)NH    2-propyl      benzyl        t-butyl          
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     Standard procedures were used for detecting and comparing the activity of the compounds of this invention. The results are summarized in Table VII. 
     CELL FREE PROTEASE INHIBITION ASSAY 
     Materials 
     HIV gag polyprotein corresponding to all of p17 and 78 amino acids of p24, produced by in vitro translation using rabbit reticulocyte lysate and mRNA prepared in vitro from plasmid encoding full length gag polyprotein linerized with the restriction enzyme Pst 1. (See S. Erickson-Viitanen et al., Aids Research and Human Retroviruses, 5 (6), 577 (1989) for plasmid construction, and basis for assay). 
     Source of protease: Either (A) crude E. coli lysate of bacteria harboring a plasmid containing HIV protease under the control of the lac promotor, used at a final concentration of 0.5 mg/ml, or (B) inclusion bodies of E. coli harboring plasmid containing HIV protease under the control of the T7 promotor (Cheng et al., Gene, in press (1990). Such inclusion bodies were solubilized in 8M urea, 50 mM Tris pH 8.0. Protease activity was recovered by dilution of the inclusion bodies 20-fold in buffer containing 50 mM Sodium Acetate, pH 5.5, 1 mM EDTA, 10% glycerol and 5% ethylene glycol. This protease source was used at a final concentration of 0.00875 mg/ml. 
     Inhibitory compounds were dissolved in sufficient DMSO to make a 25 mM stock concentration. All further dilutions were done in DMSO. 
     Set Up 
     Into sterile test tubes were placed the following: 
     1 uL inhibitor dilutions 
     14 ul HIV protease in Phosphate Buffered Saline (Gibco) 
     5 ul of in vitro translation products. 
     Reactions were incubated at 30° C., then quenched by the addition of Sample buffer. See U. K. Laemmli, Nature, 1970, 227:680-685. 
     One fourth of each sample was analyzed on an 8-16% gradient denaturing acrylamide gel (Novex, Inc), according to Laemmli. Following electrophoresis, gels were fixed, impregnated with Enhance (Du Pont NEN, Boston, Mass.) and dried according to manufacturers instructions (NEN). Dried fluorographs were exposed to film and/or quantitated using an Ambis radioanalytic scanner. 
     Each group of test compounds was compared to the values obtained for pepstatin, a well known inhibitor of acid proteases. Inhibitory concentration for 50% inhibition (IC 50 ) is determined from plots of log concentration inhibitor versus % inhibition of protease activity. 
     Biological Activity: IC 50  is the concentration necessary for reducing the activity of the enzyme by 50%. 
     HIV YIELD REDUCTION CELL ASSAY 
     Materials 
     MT2, a human T-cell line, was cultured in RPMI medium supplemented with 5% (v/v) heat inactivated fetal calf serum (FCS), L-glutamine and gentamycin. Human immunodeficiency virus strains, HIV(3B) and HIV(Rf) were propagated in H-9 cells in RPMI with 5% FCS. Poly-L-lysine (Sigma) coated cell culture plates were prepared according to the method of Harada et al. (Science 1985 229:563-566). MTT, 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyltetrazolium bromide, was obtained from Sigma. 
     Method 
     Test compounds were dissolved in dimethylsulfoxide to 5 mg/ml and serially diluted into RPMI medium to ten times the desired final concentration. MT-2 cells (5×10E5/ml) in 2.3 ml were mixed with 0.3 ml of the appropriate test compound solution and allowed to sit for 30 minutes at room temperature. HIV(3b) or HIV(Rf) (˜5×10E5 plaque forming units/ml) in 0.375 ml was added to the cell and compound mixtures and incubated for one hour at 36° C. The mixtures were centrifuged at 1000 rpm for 10 minutes and the supernatants containing unattached virus were discarded. The cell pellets were suspended in fresh RPMI containing the appropriate concentrations of test compound and placed in a 36° C., 4% CO 2  incubator. Virus was allowed to replicate for 3 days. Cultures were centrifuged for 10 minutes at 1000 rpm and the supernatants containing cell free progeny virus were removed for plaque assay. 
     The virus titers of the progeny virus produced in the presence or absence of test compounds were determined by plaque assay. Progeny virus suspensions were serially diluted in RPMI and 1.0 ml of each dilution was added to 9 ml of MT-2 cells in RPMI. Cells and virus were incubated for 3 hours at 36° C. to allow for efficient attachment of the virus to cells. Each virus and cell mixture was aliquoted equally to two wells of a six well poly-L-lysine coated culture plate and incubated overnight at 36° C., 4% CO 2 . Liquid and unattached cells were removed prior to the addition of 1.5 ml of RPMI with 0.75% (w/v) Seaplaque agarose (FMC Corp) and 5% FCS. Plates were incubated for 3 days and a second RPMI/agarose overlay was added. After an additional 3 days at 36° C., 4% CO 2 , a final overlay of phosphate-buffered saline with 0.75% Seaplaque agarose and 1 mg MTT/ml was added. The plates were incubated overnight at 36° C. Clear plaques on a purple background were counted and the number of plaque forming units of virus was calculated for each sample. The antiviral activity of test compounds was determined by the percent reduction in the virus titer with respect to virus grown in the absence of any inhibitors. 
     HIV LOW MULTIPLICITY ASSAY 
     Materials 
     MT-Z2, a human T-cell line, was cultured in RPMI medium supplemented with 5% (v/v) heat inactivated fetal calf serum (FCS), L-glutamine and gentamycin (GIBCO). Human immunodeficiency virus strains HIV(3b) and HIV (Rf) were propagated in H-9 cells in RPMI with 5% FCS. XTT, benzene-sulfonic acid, 3,3&#39;-[1-[(phenylamino)carbonyl]-3,4-tetrazolium]bis(4-methoxy-6-nitro)-, sodium salt, was obtained from Starks Associates, Inc. 
     Method 
     Test compounds were dissolved in dimethyl-sulfoxide to 5 mg/ml and serially diluted into RPMI medium to ten times the desired final concentration. MT-2 cells (5×10E4/0.1 ml) were added to each well of a 96 well culture plate and 0.02 ml of the appropriate test compound solution was added to the cells such that each compound concentration was present in two wells. The cells and compounds were allowed to sit for 30 minutes at room temperature. HIV(3b) or HIV(Rf) (˜5×10E5 plaque forming units/ml) was diluted in medium and added to the cell and compound mixtures to give a multiplicity of infection of 0.01 plaque forming unit/cell. The mixtures were incubated for 7 days at 36° C., during which time the virus replicated and caused the death of unprotected cells. The percentage of cells protected from virus induced cell death was determined by the degree of metabolism of the tetrazolium dye, XTT. In living cells, XTT was metabolized to a colored formazan product which was quantitated spectrophoto-metrically at 450 rm. The amount of colored formazan was proportional to the number of cells protected from virus by the test compound. The concentration of compound protecting either 50% (IC 50 ) or 90% (IC 90 ) with respect to an uninfected cell culture was determined. 
     
                       TABLE XVII                                                  
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         Cell Free   Cell Assay                                           
Compound # Assay         IC.sub.50                                        
                                 IC.sub.90                                
______________________________________                                    
Example 1A 12            2*      6*                                       
Example 1B 37            5*      NA                                       
Example 2A 12            10      30                                       
Example 2B 0.17           1.9     3.0                                     
Example 2C 31            --      --                                       
Example 3  383           --      --                                       
Example 4  435           --      --                                       
Example 5  65            --      --                                       
Example 6  4.8           NA      NA                                       
Example 7  502           --      --                                       
Example 8  590           --      --                                       
Example 9  0.52          NA      NA                                       
Example 10 600           --      --                                       
Example 11 20            NA      NA                                       
Example 12 4.1           NA      NA                                       
Example 13 3.3            2.3    25                                       
Example 14 480           NA      NA                                       
Example 15 260           --      --                                       
Example 16 260           --      --                                       
Example 17 278           --      --                                       
Example 18 2.3           6*      12*                                      
Example 20 0.01          &lt;1      &lt;1                                       
Example 21 0.002         6       --                                       
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