Patent Publication Number: US-2023146180-A1

Title: Pesticidally active cyclic amine compounds

Description:
The present invention relates to pesticidally active, in particular insecticidally or acaricidally active cyclic amine compounds, preferably azetidinyl, piperidinyl and piperazinyl aryl carbonyl compounds, having preferably acaricidal activity, to processes for their preparation, to compositions comprising those compounds, and to their use for controlling animal pests, including arthropods and in particular insects or representatives of the order  Acarina.    
     WO2015032280, CN106316931, WO2017195703, WO2019039429, WO 2019082808, JP 2019077618, and JP 2019085371 describe certain piperidinyl and piperazinyl pyridinyl carbonyl compounds for use for controlling pests that damage plants. 
     There have now been found novel pesticidally active azetidinyl, piperidinyl and piperazinyl aryl carbonyl compounds. 
     The present invention accordingly relates, in a first aspect, to a compound of the formula (I) 
     
       
         
         
             
             
         
       
     
     wherein 
     R 1  is CN, C(═S)NH 2  or C 1 -C 6 -haloalkyl; 
     R 2  is H, OH, halogen, C 1 -C 6 -alkoxy or C 1 -C 6 -haloalkoxy; 
     R 3  is H, halogen, cyano, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 2 -C 6 -haloalkynyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halocycloalkyl, C 1 -C 6 -alkoxy, or C 1 -C 6 -haloalkyoxy; 
     R 4  is H, halogen, cyano, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 2 -C 6 -haloalkynyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halocycloalkyl, C 1 -C 6 -alkoxy, or C 1 -C 6 -haloalkyoxy; 
     R 5  is phenyl, phenyl substituted with 1 to 3 substituents R 6 , heteroaryl (which is either a 5 or 6 membered monocyclic or a 9 or 10 membered bicyclic), heteroaryl (which is either a 5 or 6 membered monocyclic or a 9 or 10 membered bicyclic) substituted with 1 to 3 substituents R 7 ; 
     Q is a cyclic amine represented by the formula IIa or a cyclic amine represented by the formula IIb, 
     
       
         
         
             
             
         
       
     
     wherein the arrow indicates the connection to the carbonyl group; 
     p 1  is 0, 1 or 2 and indicates the number of methylene groups; 
     p 2  is 0, 1 or 2 and indicates the number of methylene groups; 
     q is 1 or 2 and indicates the number of methylene groups; 
     q 2  is 1 or 2 and indicates the number of methylene groups; 
     X is hydrogen, hydroxyl, C 1 -C 6 -alkoxy, cyano or halogen; 
     Y is cyano, C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkylsulfanyl-C 1 -C 6 -alkyl, C 1 -C 6 -alkylsulfinyl-C 1 -C 6 -alkyl, C 1 -C 6 -alkylsulfonyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkenylsulfanyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkenylsulfinyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkenylsulfonyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkynylsulfanyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkynylsulfinyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkynylsulfonyl-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxycarbonyl, C 1 -C 6 -alkoxycarbonylamino, R a R b NC(O), R c C(O)NR d , R e SO 2 NR f , R g O—N═CR h , 4 to 6 membered non-aromatic heterocyclic ring system in which one or two carbons are replaced independently by nitrogen, oxygen, sulfur, or sulfonyl, phenyl, phenyl substituted with 1 to 3 substituents R 8 , 5 or 6 membered monocyclic heteroaryl, or 5 or 6 membered monocyclic heteroaryl substituted with 1 to 3 substituents R 9 ; or X and Y together form a double bond to a nitrogen which is substituted with a group R m O; A is cyano, C 1 -C 6 -cyanoalkyl, C 2 -C 6 -cyanoalkenyl, C 3 -C 6 -cyanocycloalkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -haloalkenyl, C 3 -C 6 -halocycloalkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxycarbonyl, C 2 -C 6 -alkenyloxycarbonyl, C 2 -C 6 -alkynyloxycarbonyl, C 1 -C 6 -alkylsulfanyl-C 1 -C 6 -alkyl, C 1 -C 6 -alkylsulfinyl-C 1 -C 6 -alkyl, C 1 -C 6 -alkylsulfonyl-C 1 -C 6 -alkyl, R i SO 2 , R j R k NSO 2 , phenyl, phenyl substituted with 1 to 3 substituents R 10 , heteroaryl (which is either a 5 or 6 membered monocyclic or a 9 or 10 membered bicyclic), or heteroaryl (which is either a 5 or 6 membered monocyclic or a 9 or 10 membered bicyclic) substituted with 1 to 3 substituents R 11 ; 
     R a  and R b  are independently selected from hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 2 -C 6 -haloalkynyl, C 3 -C 6 -cycloalkyl and C 3 -C 6 -halocycloalkyl and C 1 -C 6 -alkylsulfonyl; 
     R c  and R d  are independently selected from hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 2 -C 6 -haloalkynyl, C 3 -C 6 -cycloalkyl and C 3 -C 6 -halocycloalkyl; 
     R f  is hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 2 -C 6 -haloalkynyl, C 3 -C 6 -cycloalkyl or C 3 -C 6 -halocycloalkyl; 
     R e  and R i  are independently selected from C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 2 -C 6 -haloalkynyl, C 3 -C 6 -cycloalkyl and C 3 -C 6 -halocycloalkyl; 
     R g  and R h  are independently selected from hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 2 -C 6 -haloalkynyl, C 3 -C 6 -cycloalkyl and C 3 -C 6 -halocycloalkyl; 
     R j  and R k  are independently selected from hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 2 -C 6 -haloalkynyl, C 3 -C 6 -cycloalkyl and C 3 -C 6 -halocycloalkyl; 
     R m  is hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 2 -C 6 -haloalkynyl, C 3 -C 6 -cycloalkyl or C 3 -C 6 -halocycloalkyl; and 
     R 6 , R 7 , R 8 , R 9 , R 10 , R 11  are independently selected from halogen, cyano, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -haloalkenyl, C 2 -C 6 -alkynyl, C 2 -C 6 -haloalkynyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halocycloalkyl, C 1 -C 6 -alkoxy, C 1 -C 6 -haloalkoxy, C 1 -C 6 -alkylsulfonyl and C 1 -C 6 -haloalkylsulfanyl; or an agrochemically acceptable salt, stereoisomer, enantiomer, tautomer and N-oxide of the compound of formula I. 
     Compounds of formula (I) which have at least one basic centre can form, for example, acid addition salts, for example with strong inorganic acids such as mineral acids, for example perchloric acid, sulfuric acid, nitric acid, nitrous acid, a phosphorus acid or a hydrohalic acid, with strong organic carboxylic acids, such as C 1 -C 4 alkanecarboxylic acids which are unsubstituted or substituted, for example by halogen, for example acetic acid, such as saturated or unsaturated dicarboxylic acids, for example oxalic acid, malonic acid, succinic acid, maleic acid, fumaric acid or phthalic acid, such as hydroxycarboxylic acids, for example ascorbic acid, lactic acid, malic acid, tartaric acid or citric acid, or such as benzoic acid, or with organic sulfonic acids, such as C 1 -C 4 alkane- or arylsulfonic acids which are unsubstituted or substituted, for example by halogen, for example methane- or p-toluenesulfonic acid. Compounds of formula (I) which have at least one acidic group can form, for example, salts with bases, for example mineral salts such as alkali metal or alkaline earth metal salts, for example sodium, potassium or magnesium salts, or salts with ammonia or an organic amine, such as morpholine, piperidine, pyrrolidine, a mono-, di- or tri-lower-alkylamine, for example ethyl-, diethyl-, triethyl- or dimethylpropylamine, or a mono-, di- or trihydroxy-lower-alkylamine, for example mono-, di- or triethanolamine. 
     In each case, the compounds of formula (I) according to the invention are in free form, in oxidized form as a N-oxide or in salt form, e.g. an agronomically usable salt form. 
     N-oxides are oxidized forms of tertiary amines or oxidized forms of nitrogen containing heteroaromatic compounds. They are described for instance in the book “Heterocyclic N-oxides” by A. Albini and S. Pietra, CRC Press, Boca Raton 1991. 
     The compounds of formula (I) according to the invention also include hydrates which may be formed during the salt formation. 
     The term “C 1 -C n -alkyl” as used herein refers to a saturated straight-chain or branched hydrocarbon radical attached via any of the carbon atoms having 1 to n carbon atoms, for example, any one of the radicals methyl, ethyl, n-propyl, n-butyl, n-pentyl, 2-methylbutyl, 3-methylbutyl, 2,2-dimethylpropyl, 1-ethylpropyl, n-hexyl, n-pentyl, 1,1-dimethylpropyl, 1,2-dimethylpropyl, 1-methylpentyl, 2-methylpentyl, 3-methylpentyl, 4-methylpentyl, 1,1-dimethylbutyl, 1,2-dimethylbutyl, 1,3-dimethylbutyl, 2,2-dimethylbutyl, 2,3-dimethylbutyl, 3,3-dimethylbutyl, 1-ethylbutyl, 2-ethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1-ethyl-1-methylpropyl, or 1-ethyl-2-methylpropyl. 
     The term “C 2 -C n -alkenyl” as used herein refers to a straight or branched alkenyl chain having from two to n carbon atoms and one or two double bonds, for example, ethenyl, prop-I-enyl, but-2-enyl. 
     The term “C 2 -C n -alkynyl” as used herein refers to a straight or branched alkynyl chain having from two to n carbon atoms and one triple bond, for example, ethynyl, prop-2-ynyl, but-3-ynyl, 
     The term “C 3 -C n -cycloalkyl” as used herein refers to 3-n membered cycloalkyl groups such as cyclopropane, cyclobutane, cyclopentane and cyclohexane. 
     The term “C 1 -C n -alkoxy” as used herein refers to a straight-chain or branched saturated alkyl radical having 1 to n carbon atoms (as mentioned above) which is attached via an oxygen atom, i.e., for example, any one of the radicals methoxy, ethoxy, n-propoxy, 1-methylethoxy, n-butoxy, 1-methylpropoxy, 2-methylpropoxy or 1,1-dimethylethoxy. The term “haloC 1 -C n -alkoxy” as used herein refers to a C 1 -C n -alkoxy radical where one or more hydrogen atoms on the alkyl radical is replaced by the same or different halo atom(s)—examples include trifluoromethoxy, 2-fluoroethoxy, 3-fluoropropoxy, 3,3,3-trifluoropropoxy, 4-chlorobutoxy. 
     Halogen is generally fluorine, chlorine, bromine or iodine. This also applies, correspondingly, to halogen in combination with other meanings, such as haloalkyl. 
     The term “C 1 -C n -haloalkyl” as used herein refers to a straight-chain or branched saturated alkyl radical attached via any of the carbon atoms having 1 to n carbon atoms (as mentioned above), where some or all of the hydrogen atoms in these radicals may be replaced by fluorine, chlorine, bromine and/or iodine, i.e., for example, any one of chloromethyl, dichloromethyl, trichloromethyl, fluoromethyl, difluoromethyl, trifluoromethyl, chlorofluoromethyl, dichlorofluoromethyl, chlorodifluoromethyl, 2-fluoroethyl, 2-chloroethyl, 2-bromoethyl, 2-iodoethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 2-chloro-2-fluoroethyl, 2-chloro-2,2-difluoroethyl, 2,2-dichloro-2-fluoroethyl, 2,2,2-trichloroethyl, pentafluoroethyl, 2-fluoropropyl, 3-fluoropropyl, 2,2-difluoropropyl, 2,3-difluoropropyl, 2-chloropropyl, 3-chloropropyl, 2,3-dichloropropyl, 2-bromopropyl, 3-bromopropyl, 3,3,3-trifluoropropyl, 3,3,3-trichloropropyl, 2,2,3,3,3-pentafluoropropyl, heptafluoropropyl, 1-(fluoromethyl)-2-fluoroethyl, 1-(chloromethyl)-2-chloroethyl, 1-(bromomethyl)-2-bromoethyl, 4-fluorobutyl, 4-chlorobutyl, 4-bromobutyl or nonafluorobutyl. According a term “C 1 -C 2 fluoroalkyl” would refer to a C 1 -C 2 alkyl radical which carries 1, 2, 3, 4, or 5 fluorine atoms, for example, any one of difluoromethyl, trifluoromethyl, 1-fluoroethyl, 2-fluoroethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, 1,1,2,2-tetrafluoroethyl or pentafluoroethyl. Similarly, the term “C 2 -C n -haloalkenyl” or “C 2 -C n -haloalkynyl” as used herein refers to a C 2 -C n -alkenyl or C 2 -C n -alkynyl moiety respectively substituted with one or more halo atoms which may be the same or different. Similarly, the term “C 3 -C n -halocycloalkyl” as used herein refers to a C 3 -C n -cycloakyl group substituted with one or more halo atoms which may be the same or different. 
     The term “C 1 -C n -cyanoalkyl” as used herein refers to C 1 -C n -alkyl radical having 1 to n carbon atoms (as mentioned above), where one of the hydrogen atoms in the radical is be replaced by a cyano group: for example, cyanomethyl, 2-cyanoethyl, 2-cyanopropyl, 3-cyanopropyl, 1-(cyanomethyl)-2-ethyl, 1-(methyl)-2-cyanoethyl, 4-cyanobutyl, and the like. Similarly, the term “C 1 -C n -cyanoalkenyl” or “C 1 -C n -cyanoalkynyl” refers to a C 2 -C n -alkenyl or C 1 -C n -alkynyl moiety respectively substituted with one of the hydrogen atoms in the corresponding moiety being replaced by a cyano group. 
     The term “C 1 -C n -alkylsulfanyl-C 1 -C n -alkyl” as used herein refers to an alkyl radical wherein one of the carbon atoms is replaced by a sulfur atom. 
     The term “C 1 -C n -alkylsulfinyl-C 1 -C n -alkyl” as used herein refers to an alkyl radical wherein one of the carbon atoms is replaced by a S(═O) group. 
     The term “C 1 -C n -alkylsulfonyl-C 1 -C n -alkyl” as used herein refers to an alkyl radical wherein one of the carbon atoms is replaced by a S(═O) 2  group. 
     The term “4 to 6 membered non-aromatic heterocyclic ring system in which one or two carbons is replaced by nitrogen, oxygen, sulfur, or sulfonyl,” as used herein refers to a cyclic group where one or two carbon atoms in the ring are replaced independently by nitrogen, oxygen, sulfur, or sulfonyl, and the ring is attached via a carbon, or a nitrogen atom to remainder of the compound. Examples are azetidinyl, oxetanyl, thietanyl, pyrrolidinyl, tetrahydrofuranyl, 2-oxopyrrolidinyl, 2-oxotetrahydrofuranyl, 1,1-dioxo-1,2-thiazolidinyl, 1,3-dioxolanyl, 1,3-dithiolanyl, 2-oxooxazolidinyl, piperidinyl, tetrahydropyranyl, 2-oxopiperidinyl, 1,1-dioxothiazinanyl, 2-oxotetrahydropyranyl, 1,3-dioxolanyl, 1,3-dithianyl, 2-oxo-1,3-oxazinanyl. 
     The term “phenyl-C 1 -C n -alkyl” as used herein refers to an alkyl radical substituted with a phenyl ring. 
     If there is substitution on the phenyl-C 1 -C n -alkyl group, the substitution is on the phenyl ring. 
     The term “C 1 -C n -alkoxy-C 1 -C n -alkyl” as used herein refers to an alkyl radical substituted with C 1 -C n -alkoxy group. Examples are methoxymethyl, methoxyethyl, ethoxymethyl and propoxymethyl. 
     The term “C 1 -C n -alkoxycarbonyl” as used herein refers to a C 1 -C n -alkoxy group connected to a carbonyl (C═O) radical, through which the C 1 -C n -alkoxycarbonyl is attached to the remainder of the compound. Examples are methoxycarbonyl, ethoxycarbonyl, isopropoxycarbonyl and tertiary butyloxycarbonyl. 
     The term “C 1 -C 6 -alkoxycarbonylamino” as used herein refers to a C 1 -C n -alkoxycarbonyl group connected to an amino (NH) radical, through which the C 1 -C n -alkoxycarbonylamino is attached to the remainder of the compound. Examples are 
     The term “C 2 -C n -alkenyloxycarbonyl” as used herein refers to a C 2 -C n -alkenyl group connected with an oxygen atom to a carbonyl (C═O) radical, and where the attachment to the remainder of the compound is through the carbon atom of the carbonyl. Examples are vinyloxycarbonyl and allyloxycarbonyl. 
     The term “C 2 -C n -alkynyloxycarbonyl” as used herein refers to a C 2 -C n -alkynyl group connected with an oxygen atom to a carbonyl (C═O) radical, and where the attachment to the remainder of the compound is through the carbon atom of the carbonyl. Examples are propargyloxycarbonyl (2-prop-2-ynoxycarbonyl) and 2-pent-3-ynoxycarbonyl, 
     Substituents R g O—N═CR h  have the general formula below 
     
       
         
         
             
             
         
       
     
     The term “5 or 6 membered monocyclic heteroaryl” as used herein refers to a 5 or 6 membered aromatic ring having 1 to 3 carbon atoms replaced independently by nitrogen, sulfur, or oxygen. Examples are pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, pyrrolyl, pyrazolyl, imidazolyl, triazolyl (e.g. 1.2.4 triazoyl), furanyl, thiophenyl, oxazolyl, isoxazolyl, oxadiazolyl, thiazolyl, isothiazolyl, and thiadiazolyl. Examples are heteroaryls J-1 to J-35 shown in Scheme A below. Preferred heteroaryl is J-1, J-16, J-18 or, J-20. 
     The term “9 or 10 membered bicyclic heteroaryl” as used herein refers to a 9 or 10 membered aromatic ring made up of two rings, having 1 to 3 carbon atoms replaced independently by nitrogen, sulfur, or oxygen (the heteroatoms can be in one ring or distributed amongst the two). Examples are purinyl, quinolinyl, cinnolinyl, quinoxalinyl, indolyl, indazolyl, benzimidazolyl, benzothiophenyl and benzothiazolyl. 
     Scheme A: Heteroaryl J-1 to J-35 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     As used herein, the term “controlling” refers to reducing the number of pests, eliminating pests and/or preventing further pest damage such that damage to a plant or to a plant derived product is reduced. 
     As used herein, the term “pest” refers to insects, and molluscs that are found in agriculture, horticulture, forestry, the storage of products of vegetable origin (such as fruit, grain and timber); and those pests associated with the damage of man-made structures. The term pest encompasses all stages in the life cycle of the pest. 
     As used herein, the term “effective amount” refers to the amount of the compound, or a salt thereof, which, upon single or multiple applications provides the desired effect. 
     The staggered line as used herein, for example, in formula IV-aa and IV-ba, represent the point of connection/attachment to the rest of the compound. 
     An effective amount is readily determined by the skilled person in the art, by the use of known techniques and by observing results obtained under analogous circumstances. In determining the effective amount a number of factors are considered including, but not limited to: the type of plant or derived product to be applied; the pest to be controlled &amp; its lifecycle; the particular compound applied; the type of application; and other relevant circumstances. 
     Embodiments according to the invention are provided as set out below. 
     In an embodiment of each aspect of the invention, R 1  is
         A. CN, C(═S)NH 2  or C 1 -C 3 -haloalkyl; or   B. CN, C(═S)NH 2 , difluoromethyl or trifluoromethyl; or   C. CN.       

     In an embodiment of each aspect of the invention, R 2  is
         A. hydrogen, halogen, C 1 -C 6 -alkoxy or C 1 -C 6 -haloalkoxy; or   B. hydrogen, halogen, C 1 -C 3 -alkoxy or C 1 -C 3 -haloalkoxy; or   C. hydrogen, fluorine, chlorine, methoxy, difluoromethoxy, or trifluoromethoxy; or   D. hydrogen.       

     In an embodiment of each aspect of the invention, R 3  is
         A. hydrogen, OH, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halocycloalkyl, C 1 -C 6 -alkoxy or C 1 -C 6 -haloalkyloxy; or   B. hydrogen, halogen, C 1 -C 6 -alkyl, or C 1 -C 6 -haloalkyl, C 1 -C 6 -alkoxy or C 1 -C 6 -haloalkyloxy; or   C. hydrogen, halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -alkoxy or C 1 -C 3 -haloalkyloxy; or   D. hydrogen, chlorine, fluorine, methyl, ethyl, methoxy, ethoxy, difluoromethyl, trifluoromethyl, or pentafluoroethyl; or   E. hydrogen, methyl, ethyl, methoxy, ethoxy, difluoromethyl, trifluoromethyl, or pentafluoroethyl; or   F. methyl, methoxy, ethoxy, difluoromethyl or trifluoromethyl.       

     In an embodiment of each aspect of the invention, R 4  is
         A. hydrogen, cyano, halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 3 -cycloalkyl, C 3 -C 3 -halocycloalkyl, C 1 -C 3 -alkoxy or C 1 -C 3 -haloalkyloxy; or   B. hydrogen, cyano, or halogen; or   C. hydrogen, cyano, fluorine or chlorine; or   D. hydrogen or cyano.       

     In an embodiment of each aspect of the invention, R 5  is
         A. phenyl, phenyl substituted with 1 to 3 substituents R 6 , 5 or 6 membered monocyclic heteroaryl or 5 or 6 membered monocyclic heteroaryl substituted with 1 to 3 substituents R 7 ; or   B. phenyl or phenyl substituted with 1 to 3 substituents R 6 ; or   C. phenyl substituted with 1 to 3 substituents R 6 .       

     In an embodiment of each aspect of the invention, Q is
         A. a cyclic amine represented by the formula IIa, where both p 1  and p 2  are both 0 or 1; X is hydrogen, hydroxyl, C 1 -C 3 -alkoxy, cyano, or halogen; and Y is cyano, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkylsulfanyl-C 1 -C 6 -alkyl, C 1 -C 6 -alkylsulfinyl-C 1 -C 6 -alkyl, C 1 -C 6 -alkylsulfonyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkenylsulfanyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkenylsulfinyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkenylsulfonyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkynylsulfanyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkynylsulfinyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkynylsulfonyl-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxycarbonyl, C 1 -C 6 -alkoxycarbonylamino, R a R b NC(O), R e SO 2 NR f , R g O—N═CR h , 4 to 6 membered non-aromatic heterocyclic ring system in which one or two carbons are replaced independently by nitrogen or sulfonyl, phenyl, phenyl substituted with 1 to 3 substituents R 8 , 5 or 6 membered monocyclic heteroaryl, or 5 or 6 membered monocyclic heteroaryl substituted with 1 to 3 substituents R 9 ; or X and Y together form a double bond to a nitrogen which is substituted with a group R m O; or       

     
       
         
         
             
             
         
       
         
         
           
             B. a cyclic amine represented by the formula IIa, where both p 1  and p 2  are both 0 or 1; X is hydrogen or, hydroxyl; Y is C 1 -C 3 -alkylsulfanyl-C 1 -C 3 -alkyl, C 1 -C 3 -alkylsulfinyl-C 1 -C 3 -alkyl, C 1 -C 3 -alkylsulfonyl-C 1 -C 3 -alkyl, C 3 -C 4 -alkenylsulfanyl-C 1 -C 3 -alkyl, C 3 -C 4 -alkenylsulfinyl-C 1 -C 3 -alkyl, C 3 -C 4 -alkenylsulfonyl-C 1 -C 3 -alkyl, C 3 -C 4 -alkynylsulfanyl-C 1 -C 3 -alkyl, C 3 -C 4 -alkynylsulfinyl-C 1 -C 3 -alkyl, C 3 -C 4 -alkynylsulfonyl-C 1 -C 3 -alkyl, R a R b NC(O), R e SO 2 NR f , R g O—N═CR h , 4 to 6 membered non-aromatic heterocyclic ring system in which one or two carbons are replaced independently by nitrogen or sulfonyl, 5 or 6 membered monocyclic heteroaryl, or 5 or 6 membered monocyclic heteroaryl substituted with 1 to 3 substituents R 9 ; or X and Y together form a double bond to a nitrogen which is substituted with a group R m O; or 
             C. a cyclic amine represented by the formula IIa, where both p 1  and p 2  are both 0 or 1; X is hydrogen or, hydroxyl; Y is C 1 -C 3 -alkylsulfanyl-C 1 -C 3 -alkyl, C 1 -C 3 -alkylsulfinyl-C 1 -C 3 -alkyl, C 1 -C 3 -alkylsulfonyl-C 1 -C 3 -alkyl, C 3 -C 4 -alkenylsulfanyl-C 1 -C 3 -alkyl, C 3 -C 4 -alkenylsulfinyl-C 1 -C 3 -alkyl, C 3 -C 4 -alkenylsulfonyl-C 1 -C 3 -alkyl, C 3 -C 4 -alkynylsulfanyl-C 1 -C 3 -alkyl, C 3 -C 4 -alkynylsulfinyl-C 1 -C 3 -alkyl, C 3 -C 4 -alkynylsulfonyl-C 1 -C 3 -alkyl, R a R b NC(O), R e SO 2 NR f , R g O—N═CR h , 4 to 6 membered non-aromatic heterocyclic ring system in which one or two carbons are replaced independently by nitrogen or sulfonyl, 5 or 6 membered monocyclic heteroaryl, or 5 or 6 membered monocyclic heteroaryl selected from J-1 to J-35 substituted with 1 to 3 substituents R 9 ; or X and Y together form a double bond to a nitrogen which is substituted with a group R m O; or 
             D. a cyclic amine represented by the formula IIa, where both p 1  and p 2  are both 0 or 1; X is hydrogen or, hydroxyl; Y is C 1 -C 3 -alkylsulfanyl-methyl, C 1 -C 3 -alkylsulfinyl-methyl, C 1 -C 3 -alkylsulfonyl-methyl, C 3 -C 4 -alkenylsulfanyl-methyl, C 3 -C 4 -alkenylsulfinyl-methyl, C 3 -C 4 -alkenylsulfonyl-methyl, C 3 -C 4 -alkynylsulfanyl-methyl, C 3 -C 4 -alkynylsulfinyl-methyl, C 3 -C 4 -alkynylsulfonyl-methyl, methanesulfonylamido, ethanesulfonylamido, 1,1-dioxo-1,2-thiazolidin-2-yl, 1,2,4-oxadiazole-3-yl, 2-pyridyl, substituted 2-pyridyl or, substituted 1,2,4-oxadiazole-3-yl, where the substituents for each are 1 to 3 substituents independently selected from chlorine and methyl; or X and Y together form a double bond to a nitrogen which is substituted with methoxy or ethoxy; or 
             E. a cyclic amine represented by the formula IIa, where both p 1  and p 2  are each 1; X is hydrogen; Y is C 1 -C 3 -alkylsulfanyl-methyl, C 1 -C 3 -alkylsulfinyl-methyl, C 1 -C 3 -alkylsulfonyl-methyl, C 3 -C 4 -alkenylsulfanyl-methyl, C 3 -C 4 -alkenylsulfinyl-methyl, C 3 -C 4 -alkenylsulfonyl-methyl, C 3 -C 4 -alkynylsulfanyl-methyl, C 3 -C 4 -alkynylsulfinyl-methyl, C 3 -C 4 -alkynylsulfonyl-methyl, methanesulfonylamido, ethanesulfonylamido, 1,1-dioxo-1,2-thiazolidin-2-yl, 1,2,4-oxadiazole-3-yl, 2-pyridyl, substituted 2-pyridyl or, substituted 1,2,4-oxadiazole-3-yl, where the substituents for each are 1 to 3 substituents independently selected from chlorine and methyl; or X and Y together form a double bond to a nitrogen which is substituted with methoxy or ethoxy; or 
             F. cyclic amine represented by the formula IIb; where both q 1  and q 2  are 1; and A is cyano, C 1 -C 6 -cyanoalkyl, C 2 -C 6 -cyanoalkenyl, C 3 -C 6 -cyanocycloalkyl, C 1 -C 6 -haloalkyl, C 2 -C 6 -haloalkenyl, C 3 -C 6 -halocycloalkyl, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxycarbonyl, C 2 -C 6 -alkenyloxycarbonyl, C 2 -C 6 -alkynyloxycarbonyl, C 1 -C 6 -alkylsulfanyl-C 1 -C 6 -alkyl, C 1 -C 6 -alkylsulfinyl-C 1 -C 6 -alkyl, R i SO 2 , R j R k NSO 2 , phenyl, phenyl substituted with 1 to 3 substituents R 10 , heteroaryl (which is either a 5 or 6 membered monocyclic or a 9 or 10 membered bicyclic), or heteroaryl (which is either a 5 or 6 membered monocyclic or a 9 or 10 membered bicyclic) substituted with 1 to 3 substituents R 11 ; 
           
         
       
    
     
       
         
         
             
             
         
       
         
         
           
             G. cyclic amine represented by the formula IIb; where both q 1  and q 2  are 1; and A is cyano, C 1 -C 3 -cyanoalkyl, C 2 -C 4 -cyanoalkenyl, C 3 -C 4 -cyanocycloalkyl, C 1 -C 3 -haloalkyl, C 2 -C 3 -haloalkenyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy-C 1 -C 3 -alkyl, C 1 -C 3 -alkoxycarbonyl, C 2 -C 4 -alkenyloxycarbonyl, C 2 -C 4 -alkynyloxycarbonyl, C 1 -C 3 -alkylsulfanyl-C 1 -C 3 -alkyl, C 1 -C 3 -alkylsulfinyl-C 1 -C 3 -alkyl, R i SO 2 , R j R k NSO 2 , phenyl, phenyl substituted with 1 to 3 substituents R 10 , heteroaryl (which is either a 5 or 6 membered monocyclic or a 9 or 10 membered bicyclic), or heteroaryl (which is either a 5 or 6 membered monocyclic or a 9 or 10 membered bicyclic) substituted with 1 to 3 substituents R 11 ; 
             H. cyclic amine represented by the formula IIb; where both q 1  and q 2  are 1; and A is cyano, C 1 -C 3 -cyanoalkyl, C 1 -C 3 -haloalkyl, C 2 -C 3 -haloalkenyl, C 1 -C 3 -alkoxy-C 1 -C 3 -alkyl, C 1 -C 3 -alkoxycarbonyl, C 1 -C 3 -alkylsulfanyl-C 1 -C 3 -alkyl, C 1 -C 3 -alkylsulfinyl-C 1 -C 3 -alkyl, R i SO 2 , or 5 or 6 membered monocyclic heteroaryl substituted with 1 to 3 substituents R 11 ; 
             l. cyclic amine represented by the formula IIb; where both q 1  and q 2  are 1; and A is cyano, C 1 -C 3 -cyanoalkyl, C 1 -C 3 -haloalkyl, C 2 -C 3 -haloalkenyl, C 1 -C 3 -alkoxy-C 1 -C 3 -alkyl, C 1 -C 3 -alkoxycarbonyl, C 1 -C 3 -alkylsulfanyl-C 1 -C 3 -alkyl, C 1 -C 3 -alkylsulfinyl-C 1 -C 3 -alkyl, R i SO 2 ), or 6 membered monocyclic heteroaryl substituted with 1 to 3 substituents independently selected from fluorine and chlorine, or 
             J. cyclic amine represented by the formula IIb; where both q 1  and q 2  are 1; and A is cyano, cyanomethyl, cyanoethyl, 2,2,2-trifluoroethyl, vinyloxycarbonyl, butyloxycarbonyl, methylsulfanylmethyl, ethylsulfanylethyl, methylsulfanylethyl (i.e CH 3 SCH 2 CH 2 ), ethylsulfinylethyl, ethylsulfinylmethyl, ethylsulfonylethyl, ethylsulfonylmethyl, methylsulfonylmethyl, 4-chloro-phenyl, or pyridyl substituted with 1 to 3 substituents independently selected from fluorine, chlorine, trifluoromethyl and difluoromethyl; or 
             K. cyclic amine represented by the formula IIb; where both q 1  and q 2  are 1; and A is cyano, cyanomethyl, cyanoethyl, CH 3 SCH 2 CH 2 , or pyridyl substituted with 1 to 3 substituents independently selected from fluorine, chlorine, trifluoromethyl and difluoromethyl. 
           
         
       
    
     In an embodiment of each aspect of the invention, X is
         A. hydrogen, hydroxyl, C 1 -C 3 -alkoxy, cyano or halogen; or   B. hydrogen, hydroxyl, or C 1 -C 3 -alkoxy; or   C. hydrogen, or hydroxyl; or   D. hydrogen.       

     In an embodiment of each aspect of the invention, R a  and R b  are independently selected from
         A. hydrogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -haloalkenyl, C 2 -C 4 -alkynyl, C 2 -C 4 -haloalkynyl, C 3 -C 4 -cycloalkyl and C 3 -C 4 -halocycloalkyl and C 1 -C 3 -alkylsulfonyl; or   B. hydrogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 4 -cycloalkyl and C 3 -C 4 -halocycloalkyl and C 1 -C 3 -alkylsulfonyl; or   C. hydrogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, or C 1 -C 3 -alkylsulfonyl; or   D. hydrogen, C 1 -C 3 -alkyl, or C 1 -C 3 -alkylsulfonyl; or   E. hydrogen, methyl, ethyl, methylsulfonyl, or ethylsulfonyl.       

     In an embodiment of each aspect of the invention, R c  and R d  are independently selected from
         A. C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -haloalkenyl, C 2 -C 4 -alkynyl, C 2 -C 4 -haloalkynyl, C 3 -C 4 -cycloalkyl and C 3 -C 4 -halocycloalkyl; or   B. C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 4 -cycloalkyl and C 3 -C 4 -halocycloalkyl; or   C. C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl and C 3 -C 4 -halocycloalkyl; or   D. C 1 -C 3 -alkyl and C 1 -C 3 -haloalkyl; or   E. methyl, ethyl, difluoromethyl and trifluoromethyl.       

     In an embodiment of each aspect of the invention, R f  is
         A. hydrogen, C 1 -C 3 -alkyl, or C 3 -C 4 -cycloalkyl; or   B. hydrogen or C 1 -C 3 -alkyl; or   C. hydrogen, methyl and ethyl.       

     In an embodiment of each aspect of the invention, R e  is
         A. C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -haloalkenyl, C 2 -C 4 -alkynyl, C 2 -C 4 -haloalkynyl, C 3 -C 4 -cycloalkyl or C 3 -C 4 -halocycloalkyl; or   B. C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -haloalkenyl, C 2 -C 4 -alkynyl, C 2 -C 4 -haloalkynyl, C 3 -C 4 -cycloalkyl or C 3 -C 4 -halocycloalkyl; or   C. C 1 -C 3 -alkyl or C 1 -C 3 -haloalkyl; or   D. methyl, ethyl, difluoromethyl or trifluoromethyl.       

     In an embodiment of each aspect of the invention, R i  is
         A. C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -haloalkenyl, C 2 -C 4 -alkynyl, C 2 -C 4 -haloalkynyl, C 3 -C 4 -cycloalkyl or C 3 -C 4 -halocycloalkyl; or   B. C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -haloalkenyl, C 2 -C 4 -alkynyl, C 2 -C 4 -haloalkynyl, C 3 -C 4 -cycloalkyl or C 3 -C 4 -halocycloalkyl; or   C. C 1 -C 3 -alkyl or C 1 -C 3 -haloalkyl; or   D. methyl, ethyl, difluoromethyl or trifluoromethyl.       

     In an embodiment of each aspect of the invention, R g  and R h  are independently selected from
         A. C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -haloalkenyl, C 2 -C 4 -alkynyl, C 2 -C 4 -haloalkynyl, C 3 -C 4 -cycloalkyl and C 3 -C 4 -halocycloalkyl; or   B. C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 4 -cycloalkyl and C 3 -C 4 -halocycloalkyl; or   C. C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl and C 3 -C 4 -halocycloalkyl; or   D. C 1 -C 3 -alkyl and C 1 -C 3 -haloalkyl; or   E. methyl, ethyl, difluoromethyl and trifluoromethyl; or   F. methyl and ethyl.       

     In an embodiment of each aspect of the invention, R j  and R k  are independently selected from
         A. C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -haloalkenyl, C 2 -C 4 -alkynyl, C 2 -C 4 -haloalkynyl, C 3 -C 4 -cycloalkyl and C 3 -C 4 -halocycloalkyl; or   B. C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 4 -cycloalkyl and C 3 -C 4 -halocycloalkyl; or   C. C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl and C 3 -C 4 -halocycloalkyl; or   D. C 1 -C 3 -alkyl and C 1 -C 3 -haloalkyl; or   E. methyl, ethyl, difluoromethyl and trifluoromethyl; or   F. methyl and ethyl.       

     In an embodiment of each aspect of the invention, R m  is
         A. C 1 -C 4 -alkyl; or   B. methyl, ethyl, or propyl; or   C. methy or ethyl;       

     In an embodiment of each aspect of the invention, R 6  is selected from
         A. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -haloalkenyl, C 2 -C 4 -alkynyl, C 2 -C 4 -haloalkynyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy; C 1 -C 3 -haloalkoxy; C 1 -C 3 -alkylsulfonyl and C 1 -C 3 -haloalkylsulfanyl; or   B. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy; C 1 -C 3 -haloalkoxy; C 1 -C 3 -alkylsulfonyl and C 1 -C 3 -haloalkylsulfanyl; or   C. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -alkoxy; C 1 -C 3 -haloalkoxy, C 1 -C 3 -alkylsulfonyl and C 1 -C 3 -haloalkylsulfanyl; or   D. fluorine, chlorine, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy. trifluoromethylsulfanyl and methylsulfonyl.       

     In an embodiment of each aspect of the invention, R 7  is selected from
         A. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -haloalkenyl, C 2 -C 4 -alkynyl, C 2 -C 4 -haloalkynyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy; C 1 -C 3 -haloalkoxy; C 1 -C 3 -alkylsulfonyl and C 1 -C 3 -haloalkylsulfanyl; or   B. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy; C 1 -C 3 -haloalkoxy; C 1 -C 3 -alkylsulfonyl and C 1 -C 3 -haloalkylsulfanyl; or   C. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy and C 1 -C 3 -haloalkoxy; or   D. halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -alkoxy and C 1 -C 3 -haloalkoxy; or   E. halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -alkoxy and C 1 -C 3 -haloalkoxy; or   F. halogen, C 1 -C 3 -alkyl and C 1 -C 3 -haloalkyl and C 1 -C 3 -haloalkoxy; or   G. fluorine, chlorine, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trifluoromethoxy and difluoromethoxy.       

     In an embodiment of each aspect of the invention, R 8  is selected from
         A. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -haloalkenyl, C 2 -C 4 -alkynyl, C 2 -C 4 -haloalkynyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy; C 1 -C 3 -haloalkoxy; C 1 -C 3 -alkylsulfonyl and C 1 -C 3 -haloalkylsulfanyl; or   B. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy; C 1 -C 3 -haloalkoxy; C 1 -C 3 -alkylsulfonyl and C 1 -C 3 -haloalkylsulfanyl; or   C. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy and C 1 -C 3 -haloalkoxy; or   D. halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -alkoxy and C 1 -C 3 -haloalkoxy; or   E. halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -alkoxy and C 1 -C 3 -haloalkoxy; or   F. halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl and C 1 -C 3 -haloalkoxy; or   G. fluorine, chlorine, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trifluoromethoxy and difluoromethoxy.       

     In an embodiment of each aspect of the invention, R g  is selected from
         A. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -haloalkenyl, C 2 -C 4 -alkynyl, C 2 -C 4 -haloalkynyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy; C 1 -C 3 -haloalkoxy; C 1 -C 3 -alkylsulfonyl and C 1 -C 3 -haloalkylsulfanyl; or   B. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy; C 1 -C 3 -haloalkoxy; C 1 -C 3 -alkylsulfonyl and C 1 -C 3 -haloalkylsulfanyl; or   C. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy and C 1 -C 3 -haloalkoxy; or   D. halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -alkoxy and C 1 -C 3 -haloalkoxy; or   E. halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -alkoxy and C 1 -C 3 -haloalkoxy; or   F. halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl and C 1 -C 3 -haloalkoxy; or   G. fluorine, chlorine, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trifluoromethoxy and difluoromethoxy; or   H. fluorine, chlorine, methyl and ethyl       

     In an embodiment of each aspect of the invention, R 10  is selected from
         A. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -haloalkenyl, C 2 -C 4 -alkynyl, C 2 -C 4 -haloalkynyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy; C 1 -C 3 -haloalkoxy; C 1 -C 3 -alkylsulfonyl and C 1 -C 3 -haloalkylsulfanyl; or   B. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy; C 1 -C 3 -haloalkoxy; C 1 -C 3 -alkylsulfonyl and C 1 -C 3 -haloalkylsulfanyl; or   C. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy and C 1 -C 3 -haloalkoxy; or   D. halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -alkoxy and C 1 -C 3 -haloalkoxy; or   E. halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -alkoxy and C 1 -C 3 -haloalkoxy; or   F. halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl and C 1 -C 3 -haloalkoxy; or   G. fluorine, chlorine, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trifluoromethoxy and difluoromethoxy       

     In an embodiment of each aspect of the invention, R 11  is selected from
         A. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -haloalkenyl, C 2 -C 4 -alkynyl, C 2 -C 4 -haloalkynyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy; C 1 -C 3 -haloalkoxy; C 1 -C 3 -alkylsulfonyl and C 1 -C 3 -haloalkylsulfanyl; or   B. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy; C 1 -C 3 -haloalkoxy; C 1 -C 3 -alkylsulfonyl and C 1 -C 3 -haloalkylsulfanyl; or   C. halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 4 -cycloalkyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy and C 1 -C 3 -haloalkoxy; or   D. halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -alkoxy and C 1 -C 3 -haloalkoxy; or   E. halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -alkoxy and C 1 -C 3 -haloalkoxy; or   F. halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl and C 1 -C 3 -haloalkoxy; or   G. fluorine, chlorine, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trifluoromethoxy and difluoromethoxy; or   H. fluorine, chlorine, methyl, ethyl.       

     The present invention, accordingly, makes available a compound of formula (I) having the substituents Q, R 1 , R 2 , R 3 , R 4  and R 5 , as defined above in all combinations/each permutation. Accordingly, made available, for example, is a compound of formula (I) with Q being embodiment K (i.e Q is cyclic amine represented by the formula IIb; where both q 1  and q 2  are 1; and A is cyano, cyanomethyl, cyanoethyl, CH 3 SCH 2 CH 2 , or pyridyl substituted with 1 to 3 substituents independently selected from fluorine, chlorine, trifluoromethyl and difluoromethyl); R 1  being of the first aspect (i.e. R 1  is CN, C(═S)NH 2  or C 1 -C 6 -haloalkyl); R 2  being embodiment D (i.e. R 2  is hydrogen); R 3  being embodiment A (i.e. R 3  is hydrogen, OH, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halocycloalkyl, C 1 -C 6 -alkoxy, or C 1 -C 6 -haloalkyloxy); R 4  being embodiment B (i.e. R 4  is hydrogen, cyano, or halogen); and R 5  being embodiment B (i.e. R 5  is phenyl, or phenyl substituted with 1 to 3 substituents R 6 ; with R 6  being embodiment C (i.e. R 6  is halogen, cyano, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 1 -C 3 -alkoxy; C 1 -C 3 -haloalkoxy, C 1 -C 3 -alkylsulfonyl, or C 1 -C 3 -haloalkylsulfanyl)). 
     The compounds of formula I can be represented by formulae Ia and Ib 
     
       
         
         
             
             
         
       
     
     wherein the substituents X, Y, R 1 , R 2 , R 3 , R 4  and R 5  in formula Ia are as defined for formula I; and the substituents A, R 1 , R 2 , R 3 , R 4  and R 5  in formula Ib are as defined for formula I. 
     In an embodiment of each aspect of the invention, the compound of formula (Ia) has as X hydrogen, hydroxyl, C 1 -C 6 -alkoxy, cyano or halogen; as Y cyano, C 1 -C 6 -alkoxy-C 1 -C 6 -alkyl, C 1 -C 6 -alkylsulfanyl-C 1 -C 6 -alkyl, C 1 -C 6 -alkylsulfinyl-C 1 -C 6 -alkyl, C 1 -C 6 -alkylsulfonyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkenylsulfanyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkenylsulfinyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkenylsulfonyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkynylsulfanyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkynylsulfinyl-C 1 -C 6 -alkyl, C 3 -C 6 -alkynylsulfonyl-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxycarbonyl, C 1 -C 6 -alkoxycarbonylamino, R a R b NC(O), R e SO 2 NR f , R g O—N═CR h , 4 to 6 membered non-aromatic heterocyclic ring system in which one or two carbons are replaced independently by nitrogen or sulfonyl, phenyl, phenyl substituted with 1 to 3 substituents R 8 , 5 or 6 membered monocyclic heteroaryl, or 5 or 6 membered monocyclic heteroaryl substituted with 1 to 3 substituents R 9 ; or X and Y together form a double bond to a nitrogen which is substituted with a group R m O; as R 1  CN, C(═S)NH 2  or C 1 -C 3 -haloalkyl; as R 2  hydrogen, halogen, C 1 -C 6 -alkoxy, or C 1 -C 6 -haloalkoxy; as R 3  hydrogen, OH, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halocycloalkyl, C 1 -C 6 -alkoxy, or C 1 -C 6 -haloalkyloxy; as R 4  hydrogen, cyano, halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 3 -cycloalkyl, C 3 -C 3 -halocycloalkyl, C 1 -C 3 -alkoxy, or C 1 -C 3 -haloalkyloxy; and as R 5  phenyl, phenyl substituted with 1 to 3 substituents R 6 , 5 or 6 membered monocyclic heteroaryl, or 5 or 6 membered monocyclic heteroaryl substituted with 1 to 3 substituents R 7 ; wherein R a , R b , R e , R f , R g , R h , R m , R 6 , R 7 , R 8 , R 9  are as defined in the first aspect. 
     In an embodiment of each aspect of the invention, the compound of formula (Ib) has as A cyano, C 1 -C 3 -cyanoalkyl, C 2 -C 4 -cyanoalkenyl, C 3 -C 4 -cyanocycloalkyl, C 1 -C 3 -haloalkyl, C 2 -C 3 -haloalkenyl, C 3 -C 4 -halocycloalkyl, C 1 -C 3 -alkoxy-C 1 -C 3 -alkyl, C 1 -C 3 -alkoxycarbonyl, C 2 -C 4 -alkenyloxycarbonyl, C 2 -C 4 -alkynyloxycarbonyl, C 1 -C 3 -alkylsulfanyl-C 1 -C 3 -alkyl, C 1 -C 3 -alkylsulfinyl-C 1 -C 3 -alkyl, R i SO 2 , R j R k NSO 2 , phenyl, phenyl substituted with 1 to 3 substituents R 10 , heteroaryl (which is either a 5 or 6 membered monocyclic or a 9 or 10 membered bicyclic), or heteroaryl (which is either a 5 or 6 membered monocyclic or a 9 or 10 membered bicyclic) substituted with 1 to 3 substituents R 11 ; as R 1  CN, C(═S)NH 2  or C 1 -C 3 -haloalkyl; as R 2  hydrogen, halogen, C 1 -C 6 -alkoxy or C 1 -C 6 -haloalkoxy; as R 3  hydrogen, OH, halogen, C 1 -C 6 -alkyl, C 1 -C 6 -haloalkyl, C 3 -C 6 -cycloalkyl, C 3 -C 6 -halocycloalkyl, C 1 -C 6 -alkoxy or C 1 -C 6 -haloalkyloxy; as R 4  hydrogen, cyano, halogen, C 1 -C 3 -alkyl, C 1 -C 3 -haloalkyl, C 3 -C 3 -cycloalkyl, C 3 -C 3 -halocycloalkyl, C 1 -C 3 -alkoxy, or C 1 -C 3 -haloalkyloxy; and as R 5  phenyl, phenyl substituted with 1 to 3 substituents R 6 , 5 or 6 membered monocyclic heteroaryl, or 5 or 6 membered monocyclic heteroaryl substituted with 1 to 3 substituents R 7 ; wherein R i , R j , R k , R 6 , R 7 , R 10 , R 11  are as defined in the first aspect. 
     In an embodiment of each aspect of the invention, the compound of formula (Ia) has as X hydrogen; as Y C 1 -C 3 -alkylsulfanyl-methyl, C 1 -C 3 -alkylsulfinyl-methyl, C 1 -C 3 -alkylsulfonyl-methyl, C 3 -C 4 -alkenylsulfanyl-methyl, C 3 -C 4 -alkenylsulfinyl-methyl, C 3 -C 4 -alkenylsulfonyl-methyl, C 3 -C 4 -alkynylsulfanyl-methyl, C 3 -C 4 -alkynylsulfinyl-methyl, C 3 -C 4 -alkynylsulfonyl-methyl, methanesulfonylamido, ethanesulfonylamido, 1,1-dioxo-1,2-thiazolidin-2-yl, 1,2,4-oxadiazole-3-yl, 2-pyridyl, substituted 2-pyridyl or, substituted 1,2,4-oxadiazole-3-yl, where the substituents for each are 1 to 3 substituents independently selected from chlorine and methyl; or X and Y together form a double bond to a nitrogen which is substituted with methoxy or ethoxy; as R 1  CN; as R 2  hydrogen; as R 3  methyl, methoxy, ethoxy, difluoromethyl, or trifluoromethyl; as R 4  hydrogen or cyano; as R 5  phenyl substituted with 1 to 3 substituents R 6 ; wherein R 6  is fluorine, chlorine, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy. trifluoromethylsulfanyl, or methylsulfonyl. 
     In an embodiment of each aspect of the invention, the compound of formula (Ib) has as A cyano, cyanomethyl, cyanoethyl, CH 3 SCH 2 CH 2 , or pyridyl substituted with 1 to 3 substituents independently selected from fluorine, chlorine, trifluoromethyl and difluoromethyl; as R 1  CN; as R 2  hydrogen; as R 3  methyl, methoxy, ethoxy, difluoromethyl or trifluoromethyl; as R 4  hydrogen or cyano; as R 5  phenyl substituted with 1 to 3 substituents R 6 ; wherein R 6  is fluorine, chlorine, methyl, ethyl, isopropyl, trifluoromethyl, difluoromethyl, trifluoromethoxy, difluoromethoxy. trifluoromethylsulfanyl, or methylsulfonyl. 
     In a second aspect, the present invention makes available a composition comprising a compound of formula (I) as defined in the first aspect, one or more auxiliaries and diluent, and optionally one or more other active ingredient. 
     In a third aspect, the present invention makes available a method of combating and controlling insects, acarines, nematodes or molluscs which comprises applying to a pest, to a locus of a pest, or to a plant susceptible to attack by a pest an insecticidally, acaricidally, nematicidally or molluscicidally effective amount of a compound as defined in the first aspect or a composition as defined in the second aspect. 
     In a fourth aspect, the present invention makes available a method for the protection of plant propagation material from the attack by insects, acarines, nematodes or molluscs, which comprises treating the propagation material or the site, where the propagation material is planted, with an effective amount of a compound of formula (I) as defined in the first aspect or a composition as defined in the second aspect. 
     In a fifth aspect, the present invention makes available a plant propagation material, such as a seed, comprising, or treated with or adhered thereto, a compound of formula (I) as defined in the first aspect or a composition as defined in the second aspect. 
     The present invention in a further aspect provides a method of controlling parasites in or on an animal in need thereof comprising administering an effective amount of a compound of the first aspect. The present invention further provides a method of controlling ectoparasites on an animal in need thereof comprising administering an effective amount of a compound of formula (I) as defined om the first aspect. The present invention further provides a method for preventing and/or treating diseases transmitted by ectoparasites comprising administering an effective amount of a compound of formula (I) as defined in the first aspect, to an animal in need thereof. 
     Compounds of formula (I) can be prepared by those skilled in the art following known methods. More specifically compounds of formulae I, and intermediates therefore can be prepared as described below in the schemes and examples. Certain stereogenic centers have been left unspecified for the clarity and are not intended to limit the teaching of the schemes in any way. 
     The process according to the invention for preparing compounds of formula (I) is carried out by methods known to those skilled in the art. 
     The compounds of formula (I) are new and can be prepared by reacting an acid III in which R 1 , R 2 , R 3 , R 4  and R 5  are as previously defined with an amine IV-a or IV-b in which X, Y, A, p 1 , p 2 , q 1  and q 2  are as previously defined using known amide coupling reagents, such as 1-[bis(dimethylamino)-methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluorophosphate (HATU) and a base, for example Hunig&#39;s base, in a suitable solvent, for example dimethylformamide (DMF) or dimethylacetamide (DMA) according to scheme 1. Piperidines IV-a or piperazines IV-b are commercially available, known from the literature or can be prepared by the person skilled in the art. 
     
       
         
         
             
             
         
       
     
     Alternatively the compounds of formula (I) can be prepared by reacting an acid chloride V in which R 1 , R 2 , R 3 , R 4  and R 5  are as previously defined with an amine IV-a or IV-b in which X, Y, A, p 1 , p 2  q 1  and q 2  are as previously defined in the presence of a base, for example triethylamine or pyridine, and a suitable solvent, for example dichloromethane (DCM), tetrahydrofuran (THF) or toluene, according to scheme 2. 
     
       
         
         
             
             
         
       
     
     The acid chloride V in which R 1 , R 2 , R 3 , R 4  and R 5  are as previously defined can be prepared from the corresponding acid III in which R 1 , R 2 , R 3 , R 4  and R 5  are as previously defined by treatment with for example, oxalyl chloride or thionyl chloride in the presence of catalytic quantities of DMF in inert solvents such as DCM or THE at temperatures between 20° C. to 100° C., preferably 25° C. according to scheme 3. 
     
       
         
         
             
             
         
       
     
     The acid III in which R 1 , R 2 , R 3 , R 4  and R 5  are as previously defined can be prepared by hydrolysis of the corresponding ester VI in which R 1 , R 2 , R 3 , R 4  and R 5  are as previously defined and R 12 =C 1 -C 6 -alkyl, under basic conditions, for example using an inorganic base such as lithium hydroxide, sodium hydroxide, potassium hydroxide or potassium carbonate in water, methanol, ethanol or THF, according to scheme 4. 
     
       
         
         
             
             
         
       
     
     The ester VI in which R 1 , R 2 , R 3 , R 4  and R 5  are as previously defined can be prepared by palladium catalyzed cross-coupling reaction of compound VII in which in which R 1 , R 2 , R 3 , R 4  are as previously defined and LG 1  is a leaving group, for example iodine, bromine, chlorine or a sulfonate, such as trifluoromethanesulfonate with a boronic acid VIII or a stannane reagent IX. Palladium catalyzed cross-coupling reaction are known to the person skilled in the art. These reactions can be performed in various organic or aqueous solvents compatible to these conditions, by temperatures from below 0° C. up to the boiling point of the solvent system and various palladium catalysts, for example tetrakis(triphenylphosphine)palladium(0) or palladium (II) acetate and triphenylphosphine. 
     
       
         
         
             
             
         
       
     
     The compounds of formula (I) according to the following Tables 1 to 20 can be prepared according to the methods described above. The examples which follow are intended to illustrate the invention and show preferred compounds of formula (I), in the form of a compound of formula (I-a). 
     
       
         
         
             
             
         
       
     
     Each of Tables 1 to 20, which follow the Table M below, comprises 864 compounds of the formula (I-a) in which R 1 , R 3  and R 6  have the values given in each row in Table M, and Y and X have the values given in the relevant Tables 1 to 20. 
     Thus compound 1.1 corresponds to a compound of formula (I-a) where R 1 , R 3  and R 6  are as defined in row 1 of Table M and where Y and X are as defined in Table 1; compound 14.14 corresponds to a compound of formula (I-a) where R 1 , R 3  and R 6  are as defined in row 14 of Table M and where Y and X are as defined in Table 14; and so on. 
     
       
         
           
               
               
               
               
               
             
               
                   
                 TABLE M 
               
               
                   
                   
               
               
                   
                 Comp. No 
                 R 1   
                 R 3   
                 R 6   
               
               
                   
                   
               
             
            
               
                   
                 M.1. 
                 CN 
                 H 
                 — 
               
               
                   
                 M.2. 
                 CN 
                 H 
                 2-F 
               
               
                   
                 M.3. 
                 CN 
                 H 
                 3-F 
               
               
                   
                 M.4. 
                 CN 
                 H 
                 4-F 
               
               
                   
                 M.5. 
                 CN 
                 H 
                 2-Cl 
               
               
                   
                 M.6. 
                 CN 
                 H 
                 3-Cl 
               
               
                   
                 M.7. 
                 CN 
                 H 
                 4-Cl 
               
               
                   
                 M.8. 
                 CN 
                 H 
                 2-Br 
               
               
                   
                 M.9. 
                 CN 
                 H 
                 3-Br 
               
               
                   
                 M.10. 
                 CN 
                 H 
                 4-Br 
               
               
                   
                 M.11. 
                 CN 
                 H 
                 2-CH 3   
               
               
                   
                 M.12. 
                 CN 
                 H 
                 3-CH 3   
               
               
                   
                 M.13. 
                 CN 
                 H 
                 4-CH 3   
               
               
                   
                 M.14. 
                 CN 
                 H 
                 2-CF 3   
               
               
                   
                 M.15. 
                 CN 
                 H 
                 3-CF 3   
               
               
                   
                 M.16. 
                 CN 
                 H 
                 4-CF 3   
               
               
                   
                 M.17. 
                 CN 
                 H 
                 2-OCF 3   
               
               
                   
                 M.18. 
                 CN 
                 H 
                 3-OCF 3   
               
               
                   
                 M.19. 
                 CN 
                 H 
                 4-OCF 3   
               
               
                   
                 M.20. 
                 CN 
                 H 
                 2-SCF 3   
               
               
                   
                 M.21. 
                 CN 
                 H 
                 3-SCF 3   
               
               
                   
                 M.22. 
                 CN 
                 H 
                 4-SCF 3   
               
               
                   
                 M.23. 
                 CN 
                 H 
                 2-CN 
               
               
                   
                 M.24. 
                 CN 
                 H 
                 3-CN 
               
               
                   
                 M.25. 
                 CN 
                 H 
                 4-CN 
               
               
                   
                 M.26. 
                 CN 
                 H 
                 4-SO 2 CH 3   
               
               
                   
                 M.27. 
                 CN 
                 H 
                 2,3-F 2   
               
               
                   
                 M.28. 
                 CN 
                 H 
                 2,4-F 2   
               
               
                   
                 M.29. 
                 CN 
                 H 
                 2,5-F 2   
               
               
                   
                 M.30. 
                 CN 
                 H 
                 2,6-F 2   
               
               
                   
                 M.31. 
                 CN 
                 H 
                 3,4-F 2   
               
               
                   
                 M.32. 
                 CN 
                 H 
                 3,5-F 2   
               
               
                   
                 M.33. 
                 CN 
                 H 
                 2,4-Cl 2   
               
               
                   
                 M.34. 
                 CN 
                 H 
                 2,5-Cl 2   
               
               
                   
                 M.35. 
                 CN 
                 H 
                 3,4-Cl 2   
               
               
                   
                 M.36. 
                 CN 
                 H 
                 2,3,4-F 3   
               
               
                   
                 M.37. 
                 CN 
                 H 
                 2,3,5-F 3   
               
               
                   
                 M.38. 
                 CN 
                 H 
                 2,3,6-F 3   
               
               
                   
                 M.39. 
                 CN 
                 H 
                 3,4,5-F 3   
               
               
                   
                 M.40. 
                 CN 
                 H 
                 2,4,6-F 3   
               
               
                   
                 M.41. 
                 CN 
                 H 
                 2-F, 3-Cl 
               
               
                   
                 M.42. 
                 CN 
                 H 
                 2-Cl, 4-F 
               
               
                   
                 M.43. 
                 CN 
                 H 
                 2-F, 3-CF 3   
               
               
                   
                 M.44. 
                 CN 
                 H 
                 2-F, 4-CF 3   
               
               
                   
                 M.45. 
                 CN 
                 H 
                 2-F, 5-CF 3   
               
               
                   
                 M.46. 
                 CN 
                 H 
                 3-F, 4-CF 3   
               
               
                   
                 M.47. 
                 CN 
                 H 
                 3-F, 5-CF 3   
               
               
                   
                 M.48. 
                 CN 
                 H 
                 4-F, 3-CF 3   
               
               
                   
                 M.49. 
                 CN 
                 H 
                 3,4-F 2 , 5-CF 3   
               
               
                   
                 M.50. 
                 CN 
                 H 
                 2-Cl, 3-CF 3   
               
               
                   
                 M.51. 
                 CN 
                 H 
                 2-Cl, 4-CF 3   
               
               
                   
                 M.52. 
                 CN 
                 H 
                 2-Cl, 5-CF 3   
               
               
                   
                 M.53. 
                 CN 
                 H 
                 3-Cl, 5-CF 3   
               
               
                   
                 M.54. 
                 CN 
                 H 
                 4-Cl, 3-CF 3   
               
               
                   
                 M.55. 
                 CN 
                 CH 3   
                 — 
               
               
                   
                 M.56. 
                 CN 
                 CH 3   
                 2-F 
               
               
                   
                 M.57. 
                 CN 
                 CH 3   
                 3-F 
               
               
                   
                 M.58. 
                 CN 
                 CH 3   
                 4-F 
               
               
                   
                 M.59. 
                 CN 
                 CH 3   
                 2-Cl 
               
               
                   
                 M.60. 
                 CN 
                 CH 3   
                 3-Cl 
               
               
                   
                 M.61. 
                 CN 
                 CH 3   
                 4-Cl 
               
               
                   
                 M.62. 
                 CN 
                 CH 3   
                 2-Br 
               
               
                   
                 M.63. 
                 CN 
                 CH 3   
                 3-Br 
               
               
                   
                 M.64. 
                 CN 
                 CH 3   
                 4-Br 
               
               
                   
                 M.65. 
                 CN 
                 CH 3   
                 2-CH 3   
               
               
                   
                 M.66. 
                 CN 
                 CH 3   
                 3-CH 3   
               
               
                   
                 M.67. 
                 CN 
                 CH 3   
                 4-CH 3   
               
               
                   
                 M.68. 
                 CN 
                 CH 3   
                 2-CF 3   
               
               
                   
                 M.69. 
                 CN 
                 CH 3   
                 3-CF 3   
               
               
                   
                 M.70. 
                 CN 
                 CH 3   
                 4-CF 3   
               
               
                   
                 M.71. 
                 CN 
                 CH 3   
                 2-OCF 3   
               
               
                   
                 M.72. 
                 CN 
                 CH 3   
                 3-OCF 3   
               
               
                   
                 M.73. 
                 CN 
                 CH 3   
                 4-OCF 3   
               
               
                   
                 M.74. 
                 CN 
                 CH 3   
                 2-SCF 3   
               
               
                   
                 M.75. 
                 CN 
                 CH 3   
                 3-SCF 3   
               
               
                   
                 M.76. 
                 CN 
                 CH 3   
                 4-SCF 3   
               
               
                   
                 M.77. 
                 CN 
                 CH 3   
                 2-CN 
               
               
                   
                 M.78. 
                 CN 
                 CH 3   
                 3-CN 
               
               
                   
                 M.79. 
                 CN 
                 CH 3   
                 4-CN 
               
               
                   
                 M.80. 
                 CN 
                 CH 3   
                 4-SO 2 CH 3   
               
               
                   
                 M.81. 
                 CN 
                 CH 3   
                 2,3-F 2   
               
               
                   
                 M.82. 
                 CN 
                 CH 3   
                 2,4-F 2   
               
               
                   
                 M.83. 
                 CN 
                 CH 3   
                 2,5-F 2   
               
               
                   
                 M.84. 
                 CN 
                 CH 3   
                 2,6-F 2   
               
               
                   
                 M.85. 
                 CN 
                 CH 3   
                 3,4-F 2   
               
               
                   
                 M.86. 
                 CN 
                 CH 3   
                 3,5-F 2   
               
               
                   
                 M.87. 
                 CN 
                 CH 3   
                 2,4-Cl 2   
               
               
                   
                 M.88. 
                 CN 
                 CH 3   
                 2,5-Cl 2   
               
               
                   
                 M.89. 
                 CN 
                 CH 3   
                 3,4-Cl 2   
               
               
                   
                 M.90. 
                 CN 
                 CH 3   
                 2,3,4-F 3   
               
               
                   
                 M.91. 
                 CN 
                 CH 3   
                 2,3,5-F 3   
               
               
                   
                 M.92. 
                 CN 
                 CH 3   
                 2,3,6-F 3   
               
               
                   
                 M.93. 
                 CN 
                 CH 3   
                 3,4,5-F 3   
               
               
                   
                 M.94. 
                 CN 
                 CH 3   
                 2,4,6-F 3   
               
               
                   
                 M.95. 
                 CN 
                 CH 3   
                 2-F, 3-Cl 
               
               
                   
                 M.96. 
                 CN 
                 CH 3   
                 2-Cl, 4-F 
               
               
                   
                 M.97. 
                 CN 
                 CH 3   
                 2-F, 3-CF 3   
               
               
                   
                 M.98. 
                 CN 
                 CH 3   
                 2-F, 4-CF 3   
               
               
                   
                 M.99. 
                 CN 
                 CH 3   
                 2-F, 5-CF 3   
               
               
                   
                 M.100. 
                 CN 
                 CH 3   
                 3-F, 4-CF 3   
               
               
                   
                 M.101. 
                 CN 
                 CH 3   
                 3-F, 5-CF 3   
               
               
                   
                 M.102. 
                 CN 
                 CH 3   
                 4-F, 3-CF 3   
               
               
                   
                 M.103. 
                 CN 
                 CH 3   
                 3,4-F 2 , 5-CF 3   
               
               
                   
                 M.104. 
                 CN 
                 CH 3   
                 2-Cl, 3-CF 3   
               
               
                   
                 M.105. 
                 CN 
                 CH 3   
                 2-Cl, 4-CF 3   
               
               
                   
                 M.106. 
                 CN 
                 CH 3   
                 2-Cl, 5-CF 3   
               
               
                   
                 M.107. 
                 CN 
                 CH 3   
                 3-Cl, 5-CF 3   
               
               
                   
                 M.108. 
                 CN 
                 CH 3   
                 4-Cl, 3-CF 3   
               
               
                   
                 M.109. 
                 CN 
                 CH 2 CH 3   
                 — 
               
               
                   
                 M.110. 
                 CN 
                 CH 2 CH 3   
                 2-F 
               
               
                   
                 M.111. 
                 CN 
                 CH 2 CH 3   
                 3-F 
               
               
                   
                 M.112. 
                 CN 
                 CH 2 CH 3   
                 4-F 
               
               
                   
                 M.113. 
                 CN 
                 CH 2 CH 3   
                 2-Cl 
               
               
                   
                 M.114. 
                 CN 
                 CH 2 CH 3   
                 3-Cl 
               
               
                   
                 M.115. 
                 CN 
                 CH 2 CH 3   
                 4-Cl 
               
               
                   
                 M.116. 
                 CN 
                 CH 2 CH 3   
                 2-Br 
               
               
                   
                 M.117. 
                 CN 
                 CH 2 CH 3   
                 3-Br 
               
               
                   
                 M.118. 
                 CN 
                 CH 2 CH 3   
                 4-Br 
               
               
                   
                 M.119. 
                 CN 
                 CH 2 CH 3   
                 2-CH 3   
               
               
                   
                 M.120. 
                 CN 
                 CH 2 CH 3   
                 3-CH 3   
               
               
                   
                 M.121. 
                 CN 
                 CH 2 CH 3   
                 4-CH 3   
               
               
                   
                 M.122. 
                 CN 
                 CH 2 CH 3   
                 2-CF 3   
               
               
                   
                 M.123. 
                 CN 
                 CH 2 CH 3   
                 3-CF 3   
               
               
                   
                 M.124. 
                 CN 
                 CH 2 CH 3   
                 4-CF 3   
               
               
                   
                 M.125. 
                 CN 
                 CH 2 CH 3   
                 2-OCF 3   
               
               
                   
                 M.126. 
                 CN 
                 CH 2 CH 3   
                 3-OCF 3   
               
               
                   
                 M.127. 
                 CN 
                 CH 2 CH 3   
                 4-OCF 3   
               
               
                   
                 M.128. 
                 CN 
                 CH 2 CH 3   
                 2-SCF 3   
               
               
                   
                 M.129. 
                 CN 
                 CH 2 CH 3   
                 3-SCF 3   
               
               
                   
                 M.130. 
                 CN 
                 CH 2 CH 3   
                 4-SCF 3   
               
               
                   
                 M.131. 
                 CN 
                 CH 2 CH 3   
                 2-CN 
               
               
                   
                 M.132. 
                 CN 
                 CH 2 CH 3   
                 3-CN 
               
               
                   
                 M.133. 
                 CN 
                 CH 2 CH 3   
                 4-CN 
               
               
                   
                 M.134. 
                 CN 
                 CH 2 CH 3   
                 4-SO 2 CH 3   
               
               
                   
                 M.135. 
                 CN 
                 CH 2 CH 3   
                 2,3-F 2   
               
               
                   
                 M.136. 
                 CN 
                 CH 2 CH 3   
                 2,4-F 2   
               
               
                   
                 M.137. 
                 CN 
                 CH 2 CH 3   
                 2,5-F 2   
               
               
                   
                 M.138. 
                 CN 
                 CH 2 CH 3   
                 2,6-F 2   
               
               
                   
                 M.139. 
                 CN 
                 CH 2 CH 3   
                 3,4-F 2   
               
               
                   
                 M.140. 
                 CN 
                 CH 2 CH 3   
                 3,5-F 2   
               
               
                   
                 M.141. 
                 CN 
                 CH 2 CH 3   
                 2,4-Cl 2   
               
               
                   
                 M.142. 
                 CN 
                 CH 2 CH 3   
                 2,5-Cl 2   
               
               
                   
                 M.143. 
                 CN 
                 CH 2 CH 3   
                 3,4-Cl 2   
               
               
                   
                 M.144. 
                 CN 
                 CH 2 CH 3   
                 2,3,4-F 3   
               
               
                   
                 M.145. 
                 CN 
                 CH 2 CH 3   
                 2,3,5-F 3   
               
               
                   
                 M.146. 
                 CN 
                 CH 2 CH 3   
                 2,3,6-F 3   
               
               
                   
                 M.147. 
                 CN 
                 CH 2 CH 3   
                 3,4,5-F 3   
               
               
                   
                 M.148. 
                 CN 
                 CH 2 CH 3   
                 2,4,6-F 3   
               
               
                   
                 M.149. 
                 CN 
                 CH 2 CH 3   
                 2-F, 3-Cl 
               
               
                   
                 M.150. 
                 CN 
                 CH 2 CH 3   
                 2-Cl, 4-F 
               
               
                   
                 M.151. 
                 CN 
                 CH 2 CH 3   
                 2-F, 3-CF 3   
               
               
                   
                 M.152. 
                 CN 
                 CH 2 CH 3   
                 2-F, 4-CF 3   
               
               
                   
                 M.153. 
                 CN 
                 CH 2 CH 3   
                 2-F, 5-CF 3   
               
               
                   
                 M.154. 
                 CN 
                 CH 2 CH 3   
                 3-F, 4-CF 3   
               
               
                   
                 M.155. 
                 CN 
                 CH 2 CH 3   
                 3-F, 5-CF 3   
               
               
                   
                 M.156. 
                 CN 
                 CH 2 CH 3   
                 4-F, 3-CF 3   
               
               
                   
                 M.157. 
                 CN 
                 CH 2 CH 3   
                 3,4-F 2 , 5-CF 3   
               
               
                   
                 M.158. 
                 CN 
                 CH 2 CH 3   
                 2-Cl, 3-CF 3   
               
               
                   
                 M.159. 
                 CN 
                 CH 2 CH 3   
                 2-Cl, 4-CF 3   
               
               
                   
                 M.160. 
                 CN 
                 CH 2 CH 3   
                 2-Cl, 5-CF 3   
               
               
                   
                 M.161. 
                 CN 
                 CH 2 CH 3   
                 3-Cl, 5-CF 3   
               
               
                   
                 M.162. 
                 CN 
                 CH 2 CH 3   
                 4-Cl, 3-CF 3   
               
               
                   
                 M.163. 
                 CN 
                 CF 3   
                 — 
               
               
                   
                 M.164. 
                 CN 
                 CF 3   
                 2-F 
               
               
                   
                 M.165. 
                 CN 
                 CF 3   
                 3-F 
               
               
                   
                 M.166. 
                 CN 
                 CF 3   
                 4-F 
               
               
                   
                 M.167. 
                 CN 
                 CF 3   
                 2-Cl 
               
               
                   
                 M.168. 
                 CN 
                 CF 3   
                 3-Cl 
               
               
                   
                 M.169. 
                 CN 
                 CF 3   
                 4-Cl 
               
               
                   
                 M.170. 
                 CN 
                 CF 3   
                 2-Br 
               
               
                   
                 M.171. 
                 CN 
                 CF 3   
                 3-Br 
               
               
                   
                 M.172. 
                 CN 
                 CF 3   
                 4-Br 
               
               
                   
                 M.173. 
                 CN 
                 CF 3   
                 2-CH 3   
               
               
                   
                 M.174. 
                 CN 
                 CF 3   
                 3-CH 3   
               
               
                   
                 M.175. 
                 CN 
                 CF 3   
                 4-CH 3   
               
               
                   
                 M.176. 
                 CN 
                 CF 3   
                 2-CF 3   
               
               
                   
                 M.177. 
                 CN 
                 CF 3   
                 3-CF 3   
               
               
                   
                 M.178. 
                 CN 
                 CF 3   
                 4-CF 3   
               
               
                   
                 M.179. 
                 CN 
                 CF 3   
                 2-OCF 3   
               
               
                   
                 M.180. 
                 CN 
                 CF 3   
                 3-OCF 3   
               
               
                   
                 M.181. 
                 CN 
                 CF 3   
                 4-OCF 3   
               
               
                   
                 M.182. 
                 CN 
                 CF 3   
                 2-SCF 3   
               
               
                   
                 M.183. 
                 CN 
                 CF 3   
                 3-SCF 3   
               
               
                   
                 M.184. 
                 CN 
                 CF 3   
                 4-SCF 3   
               
               
                   
                 M.185. 
                 CN 
                 CF 3   
                 2-CN 
               
               
                   
                 M.186. 
                 CN 
                 CF 3   
                 3-CN 
               
               
                   
                 M.187. 
                 CN 
                 CF 3   
                 4-CN 
               
               
                   
                 M.188. 
                 CN 
                 CF 3   
                 4-SO 2 CH 3   
               
               
                   
                 M.189. 
                 CN 
                 CF 3   
                 2,3-F 2   
               
               
                   
                 M.190. 
                 CN 
                 CF 3   
                 2,4-F 2   
               
               
                   
                 M.191. 
                 CN 
                 CF 3   
                 2,5-F 2   
               
               
                   
                 M.192. 
                 CN 
                 CF 3   
                 2,6-F 2   
               
               
                   
                 M.193. 
                 CN 
                 CF 3   
                 3,4-F 2   
               
               
                   
                 M.194. 
                 CN 
                 CF 3   
                 3,5-F 2   
               
               
                   
                 M.195. 
                 CN 
                 CF 3   
                 2,4-Cl 2   
               
               
                   
                 M.196. 
                 CN 
                 CF 3   
                 2,5-Cl 2   
               
               
                   
                 M.197. 
                 CN 
                 CF 3   
                 3,4-Cl 2   
               
               
                   
                 M.198. 
                 CN 
                 CF 3   
                 2,3,4-F 3   
               
               
                   
                 M.199. 
                 CN 
                 CF 3   
                 2,3,5-F 3   
               
               
                   
                 M.200. 
                 CN 
                 CF 3   
                 2,3,6-F 3   
               
               
                   
                 M.201. 
                 CN 
                 CF 3   
                 3,4,5-F 3   
               
               
                   
                 M.202. 
                 CN 
                 CF 3   
                 2,4,6-F 3   
               
               
                   
                 M.203. 
                 CN 
                 CF 3   
                 2-F, 3-Cl 
               
               
                   
                 M.204. 
                 CN 
                 CF 3   
                 2-Cl, 4-F 
               
               
                   
                 M.205. 
                 CN 
                 CF 3   
                 2-F, 3-CF 3   
               
               
                   
                 M.206. 
                 CN 
                 CF 3   
                 2-F, 4-CF 3   
               
               
                   
                 M.207. 
                 CN 
                 CF 3   
                 2-F, 5-CF 3   
               
               
                   
                 M.208. 
                 CN 
                 CF 3   
                 3-F, 4-CF 3   
               
               
                   
                 M.209. 
                 CN 
                 CF 3   
                 3-F, 5-CF 3   
               
               
                   
                 M.210. 
                 CN 
                 CF 3   
                 4-F, 3-CF 3   
               
               
                   
                 M.211. 
                 CN 
                 CF 3   
                 3,4-F 2 , 5-CF 3   
               
               
                   
                 M.212. 
                 CN 
                 CF 3   
                 2-Cl, 3-CF 3   
               
               
                   
                 M.213. 
                 CN 
                 CF 3   
                 2-Cl, 4-CF 3   
               
               
                   
                 M.214. 
                 CN 
                 CF 3   
                 2-Cl, 5-CF 3   
               
               
                   
                 M.215. 
                 CN 
                 CF 3   
                 3-Cl, 5-CF 3   
               
               
                   
                 M.216. 
                 CN 
                 CF 3   
                 4-Cl, 3-CF 3   
               
               
                   
                 M.217. 
                 CN 
                 CHF 2   
                 — 
               
               
                   
                 M.218. 
                 CN 
                 CHF 2   
                 2-F 
               
               
                   
                 M.219. 
                 CN 
                 CHF 2   
                 3-F 
               
               
                   
                 M.220. 
                 CN 
                 CHF 2   
                 4-F 
               
               
                   
                 M.221. 
                 CN 
                 CHF 2   
                 2-Cl 
               
               
                   
                 M.222. 
                 CN 
                 CHF 2   
                 3-Cl 
               
               
                   
                 M.223. 
                 CN 
                 CHF 2   
                 4-Cl 
               
               
                   
                 M.224. 
                 CN 
                 CHF 2   
                 2-Br 
               
               
                   
                 M.225. 
                 CN 
                 CHF 2   
                 3-Br 
               
               
                   
                 M.226. 
                 CN 
                 CHF 2   
                 4-Br 
               
               
                   
                 M.227. 
                 CN 
                 CHF 2   
                 2-CH 3   
               
               
                   
                 M.228. 
                 CN 
                 CHF 2   
                 3-CH 3   
               
               
                   
                 M.229. 
                 CN 
                 CHF 2   
                 4-CH 3   
               
               
                   
                 M.230. 
                 CN 
                 CHF 2   
                 2-CF 3   
               
               
                   
                 M.231. 
                 CN 
                 CHF 2   
                 3-CF 3   
               
               
                   
                 M.232. 
                 CN 
                 CHF 2   
                 4-CF 3   
               
               
                   
                 M.233. 
                 CN 
                 CHF 2   
                 2-OCF 3   
               
               
                   
                 M.234. 
                 CN 
                 CHF 2   
                 3-OCF 3   
               
               
                   
                 M.235. 
                 CN 
                 CHF 2   
                 4-OCF 3   
               
               
                   
                 M.236. 
                 CN 
                 CHF 2   
                 2-SCF 3   
               
               
                   
                 M.237. 
                 CN 
                 CHF 2   
                 3-SCF 3   
               
               
                   
                 M.238. 
                 CN 
                 CHF 2   
                 4-SCF 3   
               
               
                   
                 M.239. 
                 CN 
                 CHF 2   
                 2-CN 
               
               
                   
                 M.240. 
                 CN 
                 CHF 2   
                 3-CN 
               
               
                   
                 M.241. 
                 CN 
                 CHF 2   
                 4-CN 
               
               
                   
                 M.242. 
                 CN 
                 CHF 2   
                 4-SO 2 CH 3   
               
               
                   
                 M.243. 
                 CN 
                 CHF 2   
                 2,3-F 2   
               
               
                   
                 M.244. 
                 CN 
                 CHF 2   
                 2,4-F 2   
               
               
                   
                 M.245. 
                 CN 
                 CHF 2   
                 2,5-F 2   
               
               
                   
                 M.246. 
                 CN 
                 CHF 2   
                 2,6-F 2   
               
               
                   
                 M.247. 
                 CN 
                 CHF 2   
                 3,4-F 2   
               
               
                   
                 M.248. 
                 CN 
                 CHF 2   
                 3,5-F 2   
               
               
                   
                 M.249. 
                 CN 
                 CHF 2   
                 2,4-Cl 2   
               
               
                   
                 M.250. 
                 CN 
                 CHF 2   
                 2,5-Cl 2   
               
               
                   
                 M.251. 
                 CN 
                 CHF 2   
                 3,4-Cl 2   
               
               
                   
                 M.252. 
                 CN 
                 CHF 2   
                 2,3,4-F 3   
               
               
                   
                 M.253. 
                 CN 
                 CHF 2   
                 2,3,5-F 3   
               
               
                   
                 M.254. 
                 CN 
                 CHF 2   
                 2,3,6-F 3   
               
               
                   
                 M.255. 
                 CN 
                 CHF 2   
                 3,4,5-F 3   
               
               
                   
                 M.256. 
                 CN 
                 CHF 2   
                 2,4,6-F 3   
               
               
                   
                 M.257. 
                 CN 
                 CHF 2   
                 2-F, 3-Cl 
               
               
                   
                 M.258. 
                 CN 
                 CHF 2   
                 2-Cl, 4-F 
               
               
                   
                 M.259. 
                 CN 
                 CHF 2   
                 2-F, 3-CF 3   
               
               
                   
                 M.260. 
                 CN 
                 CHF 2   
                 2-F, 4-CF 3   
               
               
                   
                 M.261. 
                 CN 
                 CHF 2   
                 2-F, 5-CF 3   
               
               
                   
                 M.262. 
                 CN 
                 CHF 2   
                 3-F, 4-CF 3   
               
               
                   
                 M.263. 
                 CN 
                 CHF 2   
                 3-F, 5-CF 3   
               
               
                   
                 M.264. 
                 CN 
                 CHF 2   
                 4-F, 3-CF 3   
               
               
                   
                 M.265. 
                 CN 
                 CHF 2   
                 3,4-F 2 , 5-CF 3   
               
               
                   
                 M.266. 
                 CN 
                 CHF 2   
                 2-Cl, 3-CF 3   
               
               
                   
                 M.267. 
                 CN 
                 CHF 2   
                 2-Cl, 4-CF 3   
               
               
                   
                 M.268. 
                 CN 
                 CHF 2   
                 2-Cl, 5-CF 3   
               
               
                   
                 M.269. 
                 CN 
                 CHF 2   
                 3-Cl, 5-CF 3   
               
               
                   
                 M.270. 
                 CN 
                 CHF 2   
                 4-Cl, 3-CF 3   
               
               
                   
                 M.271. 
                 CN 
                 CF 2 CF 3   
                 — 
               
               
                   
                 M.272. 
                 CN 
                 CF 2 CF 3   
                 2-F 
               
               
                   
                 M.273. 
                 CN 
                 CF 2 CF 3   
                 3-F 
               
               
                   
                 M.274. 
                 CN 
                 CF 2 CF 3   
                 4-F 
               
               
                   
                 M.275. 
                 CN 
                 CF 2 CF 3   
                 2-Cl 
               
               
                   
                 M.276. 
                 CN 
                 CF 2 CF 3   
                 3-Cl 
               
               
                   
                 M.277. 
                 CN 
                 CF 2 CF 3   
                 4-Cl 
               
               
                   
                 M.278. 
                 CN 
                 CF 2 CF 3   
                 2-Br 
               
               
                   
                 M.279. 
                 CN 
                 CF 2 CF 3   
                 3-Br 
               
               
                   
                 M.280. 
                 CN 
                 CF 2 CF 3   
                 4-Br 
               
               
                   
                 M.281. 
                 CN 
                 CF 2 CF 3   
                 2-CH 3   
               
               
                   
                 M.282. 
                 CN 
                 CF 2 CF 3   
                 3-CH 3   
               
               
                   
                 M.283. 
                 CN 
                 CF 2 CF 3   
                 4-CH 3   
               
               
                   
                 M.284. 
                 CN 
                 CF 2 CF 3   
                 2-CF 3   
               
               
                   
                 M.285. 
                 CN 
                 CF 2 CF 3   
                 3-CF 3   
               
               
                   
                 M.286. 
                 CN 
                 CF 2 CF 3   
                 4-CF 3   
               
               
                   
                 M.287. 
                 CN 
                 CF 2 CF 3   
                 2-OCF 3   
               
               
                   
                 M.288. 
                 CN 
                 CF 2 CF 3   
                 3-OCF 3   
               
               
                   
                 M.289. 
                 CN 
                 CF 2 CF 3   
                 4-OCF 3   
               
               
                   
                 M.290. 
                 CN 
                 CF 2 CF 3   
                 2-SCF 3   
               
               
                   
                 M.291. 
                 CN 
                 CF 2 CF 3   
                 3-SCF 3   
               
               
                   
                 M.292. 
                 CN 
                 CF 2 CF 3   
                 4-SCF 3   
               
               
                   
                 M.293. 
                 CN 
                 CF 2 CF 3   
                 2-CN 
               
               
                   
                 M.294. 
                 CN 
                 CF 2 CF 3   
                 3-CN 
               
               
                   
                 M.295. 
                 CN 
                 CF 2 CF 3   
                 4-CN 
               
               
                   
                 M.296. 
                 CN 
                 CF 2 CF 3   
                 4-SO 2 CH 3   
               
               
                   
                 M.297. 
                 CN 
                 CF 2 CF 3   
                 2,3-F 2   
               
               
                   
                 M.298. 
                 CN 
                 CF 2 CF 3   
                 2,4-F 2   
               
               
                   
                 M.299. 
                 CN 
                 CF 2 CF 3   
                 2,5-F 2   
               
               
                   
                 M.300. 
                 CN 
                 CF 2 CF 3   
                 2,6-F 2   
               
               
                   
                 M.301. 
                 CN 
                 CF 2 CF 3   
                 3,4-F 2   
               
               
                   
                 M.302. 
                 CN 
                 CF 2 CF 3   
                 3,5-F 2   
               
               
                   
                 M.303. 
                 CN 
                 CF 2 CF 3   
                 2,4-Cl 2   
               
               
                   
                 M.304. 
                 CN 
                 CF 2 CF 3   
                 2,5-Cl 2   
               
               
                   
                 M.305. 
                 CN 
                 CF 2 CF 3   
                 3,4-Cl 2   
               
               
                   
                 M.306. 
                 CN 
                 CF 2 CF 3   
                 2,3,4-F 3   
               
               
                   
                 M.307. 
                 CN 
                 CF 2 CF 3   
                 2,3,5-F 3   
               
               
                   
                 M.308. 
                 CN 
                 CF 2 CF 3   
                 2,3,6-F 3   
               
               
                   
                 M.309. 
                 CN 
                 CF 2 CF 3   
                 3,4,5-F 3   
               
               
                   
                 M.310. 
                 CN 
                 CF 2 CF 3   
                 2,4,6-F 3   
               
               
                   
                 M.311. 
                 CN 
                 CF 2 CF 3   
                 2-F, 3-Cl 
               
               
                   
                 M.312. 
                 CN 
                 CF 2 CF 3   
                 2-Cl, 4-F 
               
               
                   
                 M.313. 
                 CN 
                 CF 2 CF 3   
                 2-F, 3-CF 3   
               
               
                   
                 M.314. 
                 CN 
                 CF 2 CF 3   
                 2-F, 4-CF 3   
               
               
                   
                 M.315. 
                 CN 
                 CF 2 CF 3   
                 2-F, 5-CF 3   
               
               
                   
                 M.316. 
                 CN 
                 CF 2 CF 3   
                 3-F, 4-CF 3   
               
               
                   
                 M.317. 
                 CN 
                 CF 2 CF 3   
                 3-F, 5-CF 3   
               
               
                   
                 M.318. 
                 CN 
                 CF 2 CF 3   
                 4-F, 3-CF 3   
               
               
                   
                 M.319. 
                 CN 
                 CF 2 CF 3   
                 3,4-F 2 , 5-CF 3   
               
               
                   
                 M.320. 
                 CN 
                 CF 2 CF 3   
                 2-Cl, 3-CF 3   
               
               
                   
                 M.321. 
                 CN 
                 CF 2 CF 3   
                 2-Cl, 4-CF 3   
               
               
                   
                 M.322. 
                 CN 
                 CF 2 CF 3   
                 2-Cl, 5-CF 3   
               
               
                   
                 M.323. 
                 CN 
                 CF 2 CF 3   
                 3-Cl, 5-CF 3   
               
               
                   
                 M.324. 
                 CN 
                 CF 2 CF 3   
                 4-Cl, 3-CF 3   
               
               
                   
                 M.325. 
                 CN 
                 OCH 3   
                 — 
               
               
                   
                 M.326. 
                 CN 
                 OCH 3   
                 2-F 
               
               
                   
                 M.327. 
                 CN 
                 OCH 3   
                 3-F 
               
               
                   
                 M.328. 
                 CN 
                 OCH 3   
                 4-F 
               
               
                   
                 M.329. 
                 CN 
                 OCH 3   
                 2-Cl 
               
               
                   
                 M.330. 
                 CN 
                 OCH 3   
                 3-Cl 
               
               
                   
                 M.331. 
                 CN 
                 OCH 3   
                 4-Cl 
               
               
                   
                 M.332. 
                 CN 
                 OCH 3   
                 2-Br 
               
               
                   
                 M.333. 
                 CN 
                 OCH 3   
                 3-Br 
               
               
                   
                 M.334. 
                 CN 
                 OCH 3   
                 4-Br 
               
               
                   
                 M.335. 
                 CN 
                 OCH 3   
                 2-CH 3   
               
               
                   
                 M.336. 
                 CN 
                 OCH 3   
                 3-CH 3   
               
               
                   
                 M.337. 
                 CN 
                 OCH 3   
                 4-CH 3   
               
               
                   
                 M.338. 
                 CN 
                 OCH 3   
                 2-CF 3   
               
               
                   
                 M.339. 
                 CN 
                 OCH 3   
                 3-CF 3   
               
               
                   
                 M.340. 
                 CN 
                 OCH 3   
                 4-CF 3   
               
               
                   
                 M.341. 
                 CN 
                 OCH 3   
                 2-OCF 3   
               
               
                   
                 M.342. 
                 CN 
                 OCH 3   
                 3-OCF 3   
               
               
                   
                 M.343. 
                 CN 
                 OCH 3   
                 4-OCF 3   
               
               
                   
                 M.344. 
                 CN 
                 OCH 3   
                 2-SCF 3   
               
               
                   
                 M.345. 
                 CN 
                 OCH 3   
                 3-SCF 3   
               
               
                   
                 M.346. 
                 CN 
                 OCH 3   
                 4-SCF 3   
               
               
                   
                 M.347. 
                 CN 
                 OCH 3   
                 2-CN 
               
               
                   
                 M.348. 
                 CN 
                 OCH 3   
                 3-CN 
               
               
                   
                 M.349. 
                 CN 
                 OCH 3   
                 4-CN 
               
               
                   
                 M.350. 
                 CN 
                 OCH 3   
                 4-SO 2 CH 3   
               
               
                   
                 M.351. 
                 CN 
                 OCH 3   
                 2,3-F 2   
               
               
                   
                 M.352. 
                 CN 
                 OCH 3   
                 2,4-F 2   
               
               
                   
                 M.353. 
                 CN 
                 OCH 3   
                 2,5-F 2   
               
               
                   
                 M.354. 
                 CN 
                 OCH 3   
                 2,6-F 2   
               
               
                   
                 M.355. 
                 CN 
                 OCH 3   
                 3,4-F 2   
               
               
                   
                 M.356. 
                 CN 
                 OCH 3   
                 3,5-F 2   
               
               
                   
                 M.357. 
                 CN 
                 OCH 3   
                 2,4-Cl 2   
               
               
                   
                 M.358. 
                 CN 
                 OCH 3   
                 2,5-Cl 2   
               
               
                   
                 M.359. 
                 CN 
                 OCH 3   
                 3,4-Cl 2   
               
               
                   
                 M.360. 
                 CN 
                 OCH 3   
                 2,3,4-F 3   
               
               
                   
                 M.361. 
                 CN 
                 OCH 3   
                 2,3,5-F 3   
               
               
                   
                 M.362. 
                 CN 
                 OCH 3   
                 2,3,6-F 3   
               
               
                   
                 M.363. 
                 CN 
                 OCH 3   
                 3,4,5-F 3   
               
               
                   
                 M.364. 
                 CN 
                 OCH 3   
                 2,4,6-F 3   
               
               
                   
                 M.365. 
                 CN 
                 OCH 3   
                 2-F, 3-Cl 
               
               
                   
                 M.366. 
                 CN 
                 OCH 3   
                 2-Cl, 4-F 
               
               
                   
                 M.367. 
                 CN 
                 OCH 3   
                 2-F, 3-CF 3   
               
               
                   
                 M.368. 
                 CN 
                 OCH 3   
                 2-F, 4-CF 3   
               
               
                   
                 M.369. 
                 CN 
                 OCH 3   
                 2-F, 5-CF 3   
               
               
                   
                 M.370. 
                 CN 
                 OCH 3   
                 3-F, 4-CF 3   
               
               
                   
                 M.371. 
                 CN 
                 OCH 3   
                 3-F, 5-CF 3   
               
               
                   
                 M.372. 
                 CN 
                 OCH 3   
                 4-F, 3-CF 3   
               
               
                   
                 M.373. 
                 CN 
                 OCH 3   
                 3,4-F 2 , 5-CF 3   
               
               
                   
                 M.374. 
                 CN 
                 OCH 3   
                 2-Cl, 3-CF 3   
               
               
                   
                 M.375. 
                 CN 
                 OCH 3   
                 2-Cl, 4-CF 3   
               
               
                   
                 M.376. 
                 CN 
                 OCH 3   
                 2-Cl, 5-CF 3   
               
               
                   
                 M.377. 
                 CN 
                 OCH 3   
                 3-Cl, 5-CF 3   
               
               
                   
                 M.378. 
                 CN 
                 OCH 3   
                 4-Cl, 3-CF 3   
               
               
                   
                 M.379. 
                 CN 
                 OCH 2 CH 3   
                 — 
               
               
                   
                 M.380. 
                 CN 
                 OCH 2 CH 3   
                 2-F 
               
               
                   
                 M.381. 
                 CN 
                 OCH 2 CH 3   
                 3-F 
               
               
                   
                 M.382. 
                 CN 
                 OCH 2 CH 3   
                 4-F 
               
               
                   
                 M.383. 
                 CN 
                 OCH 2 CH 3   
                 2-Cl 
               
               
                   
                 M.384. 
                 CN 
                 OCH 2 CH 3   
                 3-Cl 
               
               
                   
                 M.385. 
                 CN 
                 OCH 2 CH 3   
                 4-Cl 
               
               
                   
                 M.386. 
                 CN 
                 OCH 2 CH 3   
                 2-Br 
               
               
                   
                 M.387. 
                 CN 
                 OCH 2 CH 3   
                 3-Br 
               
               
                   
                 M.388. 
                 CN 
                 OCH 2 CH 3   
                 4-Br 
               
               
                   
                 M.389. 
                 CN 
                 OCH 2 CH 3   
                 2-CH 3   
               
               
                   
                 M.390. 
                 CN 
                 OCH 2 CH 3   
                 3-CH 3   
               
               
                   
                 M.391. 
                 CN 
                 OCH 2 CH 3   
                 4-CH 3   
               
               
                   
                 M.392. 
                 CN 
                 OCH 2 CH 3   
                 2-CF 3   
               
               
                   
                 M.393. 
                 CN 
                 OCH 2 CH 3   
                 3-CF 3   
               
               
                   
                 M.394. 
                 CN 
                 OCH 2 CH 3   
                 4-CF 3   
               
               
                   
                 M.395. 
                 CN 
                 OCH 2 CH 3   
                 2-OCF 3   
               
               
                   
                 M.396. 
                 CN 
                 OCH 2 CH 3   
                 3-OCF 3   
               
               
                   
                 M.397. 
                 CN 
                 OCH 2 CH 3   
                 4-OCF 3   
               
               
                   
                 M.398. 
                 CN 
                 OCH 2 CH 3   
                 2-SCF 3   
               
               
                   
                 M.399. 
                 CN 
                 OCH 2 CH 3   
                 3-SCF 3   
               
               
                   
                 M.400. 
                 CN 
                 OCH 2 CH 3   
                 4-SCF 3   
               
               
                   
                 M.401. 
                 CN 
                 OCH 2 CH 3   
                 2-CN 
               
               
                   
                 M.402. 
                 CN 
                 OCH 2 CH 3   
                 3-CN 
               
               
                   
                 M.403. 
                 CN 
                 OCH 2 CH 3   
                 4-CN 
               
               
                   
                 M.404. 
                 CN 
                 OCH 2 CH 3   
                 4-SO 2 CH 3   
               
               
                   
                 M.405. 
                 CN 
                 OCH 2 CH 3   
                 2,3-F 2   
               
               
                   
                 M.406. 
                 CN 
                 OCH 2 CH 3   
                 2,4-F 2   
               
               
                   
                 M.407. 
                 CN 
                 OCH 2 CH 3   
                 2,5-F 2   
               
               
                   
                 M.408. 
                 CN 
                 OCH 2 CH 3   
                 2,6-F 2   
               
               
                   
                 M.409. 
                 CN 
                 OCH 2 CH 3   
                 3,4-F 2   
               
               
                   
                 M.410. 
                 CN 
                 OCH 2 CH 3   
                 3,5-F 2   
               
               
                   
                 M.411. 
                 CN 
                 OCH 2 CH 3   
                 2,4-Cl 2   
               
               
                   
                 M.412. 
                 CN 
                 OCH 2 CH 3   
                 2,5-Cl 2   
               
               
                   
                 M.413. 
                 CN 
                 OCH 2 CH 3   
                 3,4-Cl 2   
               
               
                   
                 M.414. 
                 CN 
                 OCH 2 CH 3   
                 2,3,4-F 3   
               
               
                   
                 M.415. 
                 CN 
                 OCH 2 CH 3   
                 2,3,5-F 3   
               
               
                   
                 M.416. 
                 CN 
                 OCH 2 CH 3   
                 2,3,6-F 3   
               
               
                   
                 M.417. 
                 CN 
                 OCH 2 CH 3   
                 3,4,5-F 3   
               
               
                   
                 M.418. 
                 CN 
                 OCH 2 CH 3   
                 2,4,6-F 3   
               
               
                   
                 M.419. 
                 CN 
                 OCH 2 CH 3   
                 2-F, 3-Cl 
               
               
                   
                 M.420. 
                 CN 
                 OCH 2 CH 3   
                 2-Cl, 4-F 
               
               
                   
                 M.421. 
                 CN 
                 OCH 2 CH 3   
                 2-F, 3-CF 3   
               
               
                   
                 M.422. 
                 CN 
                 OCH 2 CH 3   
                 2-F, 4-CF 3   
               
               
                   
                 M.423. 
                 CN 
                 OCH 2 CH 3   
                 2-F, 5-CF 3   
               
               
                   
                 M.424. 
                 CN 
                 OCH 2 CH 3   
                 3-F, 4-CF 3   
               
               
                   
                 M.425. 
                 CN 
                 OCH 2 CH 3   
                 3-F, 5-CF 3   
               
               
                   
                 M.426. 
                 CN 
                 OCH 2 CH 3   
                 4-F, 3-CF 3   
               
               
                   
                 M.427. 
                 CN 
                 OCH 2 CH 3   
                 3,4-F 2 , 5-CF 3   
               
               
                   
                 M.428. 
                 CN 
                 OCH 2 CH 3   
                 2-Cl, 3-CF 3   
               
               
                   
                 M.429. 
                 CN 
                 OCH 2 CH 3   
                 2-Cl, 4-CF 3   
               
               
                   
                 M.430. 
                 CN 
                 OCH 2 CH 3   
                 2-Cl, 5-CF 3   
               
               
                   
                 M.431. 
                 CN 
                 OCH 2 CH 3   
                 3-Cl, 5-CF 3   
               
               
                   
                 M.432. 
                 CN 
                 OCH 2 CH 3   
                 4-Cl, 3-CF 3   
               
               
                   
                 M.433. 
                 C(═S)NH 2   
                 H 
                 — 
               
               
                   
                 M.434. 
                 C(═S)NH 2   
                 H 
                 2-F 
               
               
                   
                 M.435. 
                 C(═S)NH 2   
                 H 
                 3-F 
               
               
                   
                 M.436. 
                 C(═S)NH 2   
                 H 
                 4-F 
               
               
                   
                 M.437. 
                 C(═S)NH 2   
                 H 
                 2-Cl 
               
               
                   
                 M.438. 
                 C(═S)NH 2   
                 H 
                 3-Cl 
               
               
                   
                 M.439. 
                 C(═S)NH 2   
                 H 
                 4-Cl 
               
               
                   
                 M.440. 
                 C(═S)NH 2   
                 H 
                 2-Br 
               
               
                   
                 M.441. 
                 C(═S)NH 2   
                 H 
                 3-Br 
               
               
                   
                 M.442. 
                 C(═S)NH 2   
                 H 
                 4-Br 
               
               
                   
                 M.443. 
                 C(═S)NH 2   
                 H 
                 2-CH 3   
               
               
                   
                 M.444. 
                 C(═S)NH 2   
                 H 
                 3-CH 3   
               
               
                   
                 M.445. 
                 C(═S)NH 2   
                 H 
                 4-CH 3   
               
               
                   
                 M.446. 
                 C(═S)NH 2   
                 H 
                 2-CF 3   
               
               
                   
                 M.447. 
                 C(═S)NH 2   
                 H 
                 3-CF 3   
               
               
                   
                 M.448. 
                 C(═S)NH 2   
                 H 
                 4-CF 3   
               
               
                   
                 M.449. 
                 C(═S)NH 2   
                 H 
                 2-OCF 3   
               
               
                   
                 M.450. 
                 C(═S)NH 2   
                 H 
                 3-OCF 3   
               
               
                   
                 M.451. 
                 C(═S)NH 2   
                 H 
                 4-OCF 3   
               
               
                   
                 M.452. 
                 C(═S)NH 2   
                 H 
                 2-SCF 3   
               
               
                   
                 M.453. 
                 C(═S)NH 2   
                 H 
                 3-SCF 3   
               
               
                   
                 M.454. 
                 C(═S)NH 2   
                 H 
                 4-SCF 3   
               
               
                   
                 M.455. 
                 C(═S)NH 2   
                 H 
                 2-CN 
               
               
                   
                 M.456. 
                 C(═S)NH 2   
                 H 
                 3-CN 
               
               
                   
                 M.457. 
                 C(═S)NH 2   
                 H 
                 4-CN 
               
               
                   
                 M.458. 
                 C(═S)NH 2   
                 H 
                 4-SO 2 CH 3   
               
               
                   
                 M.459. 
                 C(═S)NH 2   
                 H 
                 2,3-F 2   
               
               
                   
                 M.460. 
                 C(═S)NH 2   
                 H 
                 2,4-F 2   
               
               
                   
                 M.461. 
                 C(═S)NH 2   
                 H 
                 2,5-F 2   
               
               
                   
                 M.462. 
                 C(═S)NH 2   
                 H 
                 2,6-F 2   
               
               
                   
                 M.463. 
                 C(═S)NH 2   
                 H 
                 3,4-F 2   
               
               
                   
                 M.464. 
                 C(═S)NH 2   
                 H 
                 3,5-F 2   
               
               
                   
                 M.465. 
                 C(═S)NH 2   
                 H 
                 2,4-Cl 2   
               
               
                   
                 M.466. 
                 C(═S)NH 2   
                 H 
                 2,5-Cl 2   
               
               
                   
                 M.467. 
                 C(═S)NH 2   
                 H 
                 3,4-Cl 2   
               
               
                   
                 M.468. 
                 C(═S)NH 2   
                 H 
                 2,3,4-F 3   
               
               
                   
                 M.469. 
                 C(═S)NH 2   
                 H 
                 2,3,5-F 3   
               
               
                   
                 M.470. 
                 C(═S)NH 2   
                 H 
                 2,3,6-F 3   
               
               
                   
                 M.471. 
                 C(═S)NH 2   
                 H 
                 3,4,5-F 3   
               
               
                   
                 M.472. 
                 C(═S)NH 2   
                 H 
                 2,4,6-F 3   
               
               
                   
                 M.473. 
                 C(═S)NH 2   
                 H 
                 2-F, 3-Cl 
               
               
                   
                 M.474. 
                 C(═S)NH 2   
                 H 
                 2-Cl, 4-F 
               
               
                   
                 M.475. 
                 C(═S)NH 2   
                 H 
                 2-F, 3-CF 3   
               
               
                   
                 M.476. 
                 C(═S)NH 2   
                 H 
                 2-F, 4-CF 3   
               
               
                   
                 M.477. 
                 C(═S)NH 2   
                 H 
                 2-F, 5-CF 3   
               
               
                   
                 M.478. 
                 C(═S)NH 2   
                 H 
                 3-F, 4-CF 3   
               
               
                   
                 M.479. 
                 C(═S)NH 2   
                 H 
                 3-F, 5-CF 3   
               
               
                   
                 M.480. 
                 C(═S)NH 2   
                 H 
                 4-F, 3-CF 3   
               
               
                   
                 M.481. 
                 C(═S)NH 2   
                 H 
                 3,4-F 2 , 5-CF 3   
               
               
                   
                 M.482. 
                 C(═S)NH 2   
                 H 
                 2-Cl, 3-CF 3   
               
               
                   
                 M.483. 
                 C(═S)NH 2   
                 H 
                 2-Cl, 4-CF 3   
               
               
                   
                 M.484. 
                 C(═S)NH 2   
                 H 
                 2-Cl, 5-CF 3   
               
               
                   
                 M.485. 
                 C(═S)NH 2   
                 H 
                 3-Cl, 5-CF 3   
               
               
                   
                 M.486. 
                 C(═S)NH 2   
                 H 
                 4-Cl, 3-CF 3   
               
               
                   
                 M.487. 
                 C(═S)NH 2   
                 CH 3   
                 — 
               
               
                   
                 M.488. 
                 C(═S)NH 2   
                 CH 3   
                 2-F 
               
               
                   
                 M.489. 
                 C(═S)NH 2   
                 CH 3   
                 3-F 
               
               
                   
                 M.490. 
                 C(═S)NH 2   
                 CH 3   
                 4-F 
               
               
                   
                 M.491. 
                 C(═S)NH 2   
                 CH 3   
                 2-Cl 
               
               
                   
                 M.492. 
                 C(═S)NH 2   
                 CH 3   
                 3-Cl 
               
               
                   
                 M.493. 
                 C(═S)NH 2   
                 CH 3   
                 4-Cl 
               
               
                   
                 M.494. 
                 C(═S)NH 2   
                 CH 3   
                 2-Br 
               
               
                   
                 M.495. 
                 C(═S)NH 2   
                 CH 3   
                 3-Br 
               
               
                   
                 M.496. 
                 C(═S)NH 2   
                 CH 3   
                 4-Br 
               
               
                   
                 M.497. 
                 C(═S)NH 2   
                 CH 3   
                 2-CH 3   
               
               
                   
                 M.498. 
                 C(═S)NH 2   
                 CH 3   
                 3-CH 3   
               
               
                   
                 M.499. 
                 C(═S)NH 2   
                 CH 3   
                 4-CH 3   
               
               
                   
                 M.500. 
                 C(═S)NH 2   
                 CH 3   
                 2-CF 3   
               
               
                   
                 M.501. 
                 C(═S)NH 2   
                 CH 3   
                 3-CF 3   
               
               
                   
                 M.502. 
                 C(═S)NH 2   
                 CH 3   
                 4-CF 3   
               
               
                   
                 M.503. 
                 C(═S)NH 2   
                 CH 3   
                 2-OCF 3   
               
               
                   
                 M.504. 
                 C(═S)NH 2   
                 CH 3   
                 3-OCF 3   
               
               
                   
                 M.505. 
                 C(═S)NH 2   
                 CH 3   
                 4-OCF 3   
               
               
                   
                 M.506. 
                 C(═S)NH 2   
                 CH 3   
                 2-SCF 3   
               
               
                   
                 M.507. 
                 C(═S)NH 2   
                 CH 3   
                 3-SCF 3   
               
               
                   
                 M.508. 
                 C(═S)NH 2   
                 CH 3   
                 4-SCF 3   
               
               
                   
                 M.509. 
                 C(═S)NH 2   
                 CH 3   
                 2-CN 
               
               
                   
                 M.510. 
                 C(═S)NH 2   
                 CH 3   
                 3-CN 
               
               
                   
                 M.511. 
                 C(═S)NH 2   
                 CH 3   
                 4-CN 
               
               
                   
                 M.512. 
                 C(═S)NH 2   
                 CH 3   
                 4-SO 2 CH 3   
               
               
                   
                 M.513. 
                 C(═S)NH 2   
                 CH 3   
                 2,3-F 2   
               
               
                   
                 M.514. 
                 C(═S)NH 2   
                 CH 3   
                 2,4-F 2   
               
               
                   
                 M.515. 
                 C(═S)NH 2   
                 CH 3   
                 2,5-F 2   
               
               
                   
                 M.516. 
                 C(═S)NH 2   
                 CH 3   
                 2,6-F 2   
               
               
                   
                 M.517. 
                 C(═S)NH 2   
                 CH 3   
                 3,4-F 2   
               
               
                   
                 M.518. 
                 C(═S)NH 2   
                 CH 3   
                 3,5-F 2   
               
               
                   
                 M.519. 
                 C(═S)NH 2   
                 CH 3   
                 2,4-Cl 2   
               
               
                   
                 M.520. 
                 C(═S)NH 2   
                 CH 3   
                 2,5-Cl 2   
               
               
                   
                 M.521. 
                 C(═S)NH 2   
                 CH 3   
                 3,4-Cl 2   
               
               
                   
                 M.522. 
                 C(═S)NH 2   
                 CH 3   
                 2,3,4-F 3   
               
               
                   
                 M.523. 
                 C(═S)NH 2   
                 CH 3   
                 2,3,5-F 3   
               
               
                   
                 M.524. 
                 C(═S)NH 2   
                 CH 3   
                 2,3,6-F 3   
               
               
                   
                 M.525. 
                 C(═S)NH 2   
                 CH 3   
                 3,4,5-F 3   
               
               
                   
                 M.526. 
                 C(═S)NH 2   
                 CH 3   
                 2,4,6-F 3   
               
               
                   
                 M.527. 
                 C(═S)NH 2   
                 CH 3   
                 2-F, 3-Cl 
               
               
                   
                 M.528. 
                 C(═S)NH 2   
                 CH 3   
                 2-Cl, 4-F 
               
               
                   
                 M.529. 
                 C(═S)NH 2   
                 CH 3   
                 2-F, 3-CF 3   
               
               
                   
                 M.530. 
                 C(═S)NH 2   
                 CH 3   
                 2-F, 4-CF 3   
               
               
                   
                 M.531. 
                 C(═S)NH 2   
                 CH 3   
                 2-F, 5-CF 3   
               
               
                   
                 M.532. 
                 C(═S)NH 2   
                 CH 3   
                 3-F, 4-CF 3   
               
               
                   
                 M.533. 
                 C(═S)NH 2   
                 CH 3   
                 3-F, 5-CF 3   
               
               
                   
                 M.534. 
                 C(═S)NH 2   
                 CH 3   
                 4-F, 3-CF 3   
               
               
                   
                 M.535. 
                 C(═S)NH 2   
                 CH 3   
                 3,4-F 2 , 5-CF 3   
               
               
                   
                 M.536. 
                 C(═S)NH 2   
                 CH 3   
                 2-Cl, 3-CF 3   
               
               
                   
                 M.537. 
                 C(═S)NH 2   
                 CH 3   
                 2-Cl, 4-CF 3   
               
               
                   
                 M.538. 
                 C(═S)NH 2   
                 CH 3   
                 2-Cl, 5-CF 3   
               
               
                   
                 M.539. 
                 C(═S)NH 2   
                 CH 3   
                 3-Cl, 5-CF 3   
               
               
                   
                 M.540. 
                 C(═S)NH 2   
                 CH 3   
                 4-Cl, 3-CF 3   
               
               
                   
                 M.541. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 — 
               
               
                   
                 M.542. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2-F 
               
               
                   
                 M.543. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 3-F 
               
               
                   
                 M.544. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 4-F 
               
               
                   
                 M.545. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2-Cl 
               
               
                   
                 M.546. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 3-Cl 
               
               
                   
                 M.547. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 4-Cl 
               
               
                   
                 M.548. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2-Br 
               
               
                   
                 M.549. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 3-Br 
               
               
                   
                 M.550. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 4-Br 
               
               
                   
                 M.551. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2-CH 3   
               
               
                   
                 M.552. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 3-CH 3   
               
               
                   
                 M.553. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 4-CH 3   
               
               
                   
                 M.554. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2-CF 3   
               
               
                   
                 M.555. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 3-CF 3   
               
               
                   
                 M.556. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 4-CF 3   
               
               
                   
                 M.557. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2-OCF 3   
               
               
                   
                 M.558. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 3-OCF 3   
               
               
                   
                 M.559. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 4-OCF 3   
               
               
                   
                 M.560. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2-SCF 3   
               
               
                   
                 M.561. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 3-SCF 3   
               
               
                   
                 M.562. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 4-SCF 3   
               
               
                   
                 M.563. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2-CN 
               
               
                   
                 M.564. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 3-CN 
               
               
                   
                 M.565. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 4-CN 
               
               
                   
                 M.566. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 4-SO 2 CH 3   
               
               
                   
                 M.567. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2,3-F 2   
               
               
                   
                 M.568. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2,4-F 2   
               
               
                   
                 M.569. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2,5-F 2   
               
               
                   
                 M.570. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2,6-F 2   
               
               
                   
                 M.571. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 3,4-F 2   
               
               
                   
                 M.572. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 3,5-F 2   
               
               
                   
                 M.573. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2,4-Cl 2   
               
               
                   
                 M.574. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2,5-Cl 2   
               
               
                   
                 M.575. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 3,4-Cl 2   
               
               
                   
                 M.576. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2,3,4-F 3   
               
               
                   
                 M.577. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2,3,5-F 3   
               
               
                   
                 M.578. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2,3,6-F 3   
               
               
                   
                 M.579. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 3,4,5-F 3   
               
               
                   
                 M.580. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2,4,6-F 3   
               
               
                   
                 M.581. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2-F, 3-Cl 
               
               
                   
                 M.582. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2-Cl, 4-F 
               
               
                   
                 M.583. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2-F, 3-CF 3   
               
               
                   
                 M.584. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2-F, 4-CF 3   
               
               
                   
                 M.585. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2-F, 5-CF 3   
               
               
                   
                 M.586. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 3-F, 4-CF 3   
               
               
                   
                 M.587. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 3-F, 5-CF 3   
               
               
                   
                 M.588. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 4-F, 3-CF 3   
               
               
                   
                 M.589. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 3,4-F 2 , 5-CF 3   
               
               
                   
                 M.590. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2-Cl, 3-CF 3   
               
               
                   
                 M.591. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2-Cl, 4-CF 3   
               
               
                   
                 M.592. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 2-Cl, 5-CF 3   
               
               
                   
                 M.593. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 3-Cl, 5-CF 3   
               
               
                   
                 M.594. 
                 C(═S)NH 2   
                 CH 2 CH 3   
                 4-Cl, 3-CF 3   
               
               
                   
                 M.595. 
                 C(═S)NH 2   
                 CF 3   
                 — 
               
               
                   
                 M.596. 
                 C(═S)NH 2   
                 CF 3   
                 2-F 
               
               
                   
                 M.597. 
                 C(═S)NH 2   
                 CF 3   
                 3-F 
               
               
                   
                 M.598. 
                 C(═S)NH 2   
                 CF 3   
                 4-F 
               
               
                   
                 M.599. 
                 C(═S)NH 2   
                 CF 3   
                 2-Cl 
               
               
                   
                 M.600. 
                 C(═S)NH 2   
                 CF 3   
                 3-Cl 
               
               
                   
                 M.601. 
                 C(═S)NH 2   
                 CF 3   
                 4-Cl 
               
               
                   
                 M.602. 
                 C(═S)NH 2   
                 CF 3   
                 2-Br 
               
               
                   
                 M.603. 
                 C(═S)NH 2   
                 CF 3   
                 3-Br 
               
               
                   
                 M.604. 
                 C(═S)NH 2   
                 CF 3   
                 4-Br 
               
               
                   
                 M.605. 
                 C(═S)NH 2   
                 CF 3   
                 2-CH 3   
               
               
                   
                 M.606. 
                 C(═S)NH 2   
                 CF 3   
                 3-CH 3   
               
               
                   
                 M.607. 
                 C(═S)NH 2   
                 CF 3   
                 4-CH 3   
               
               
                   
                 M.608. 
                 C(═S)NH 2   
                 CF 3   
                 2-CF 3   
               
               
                   
                 M.609. 
                 C(═S)NH 2   
                 CF 3   
                 3-CF 3   
               
               
                   
                 M.610. 
                 C(═S)NH 2   
                 CF 3   
                 4-CF 3   
               
               
                   
                 M.611. 
                 C(═S)NH 2   
                 CF 3   
                 2-OCF 3   
               
               
                   
                 M.612. 
                 C(═S)NH 2   
                 CF 3   
                 3-OCF 3   
               
               
                   
                 M.613. 
                 C(═S)NH 2   
                 CF 3   
                 4-OCF 3   
               
               
                   
                 M.614. 
                 C(═S)NH 2   
                 CF 3   
                 2-SCF 3   
               
               
                   
                 M.615. 
                 C(═S)NH 2   
                 CF 3   
                 3-SCF 3   
               
               
                   
                 M.616. 
                 C(═S)NH 2   
                 CF 3   
                 4-SCF 3   
               
               
                   
                 M.617. 
                 C(═S)NH 2   
                 CF 3   
                 2-CN 
               
               
                   
                 M.618. 
                 C(═S)NH 2   
                 CF 3   
                 3-CN 
               
               
                   
                 M.619. 
                 C(═S)NH 2   
                 CF 3   
                 4-CN 
               
               
                   
                 M.620. 
                 C(═S)NH 2   
                 CF 3   
                 4-SO 2 CH 3   
               
               
                   
                 M.621. 
                 C(═S)NH 2   
                 CF 3   
                 2,3-F 2   
               
               
                   
                 M.622. 
                 C(═S)NH 2   
                 CF 3   
                 2,4-F 2   
               
               
                   
                 M.623. 
                 C(═S)NH 2   
                 CF 3   
                 2,5-F 2   
               
               
                   
                 M.624. 
                 C(═S)NH 2   
                 CF 3   
                 2,6-F 2   
               
               
                   
                 M.625. 
                 C(═S)NH 2   
                 CF 3   
                 3,4-F 2   
               
               
                   
                 M.626. 
                 C(═S)NH 2   
                 CF 3   
                 3,5-F 2   
               
               
                   
                 M.627. 
                 C(═S)NH 2   
                 CF 3   
                 2,4-Cl 2   
               
               
                   
                 M.628. 
                 C(═S)NH 2   
                 CF 3   
                 2,5-Cl 2   
               
               
                   
                 M.629. 
                 C(═S)NH 2   
                 CF 3   
                 3,4-Cl 2   
               
               
                   
                 M.630. 
                 C(═S)NH 2   
                 CF 3   
                 2,3,4-F 3   
               
               
                   
                 M.631. 
                 C(═S)NH 2   
                 CF 3   
                 2,3,5-F 3   
               
               
                   
                 M.632. 
                 C(═S)NH 2   
                 CF 3   
                 2,3,6-F 3   
               
               
                   
                 M.633. 
                 C(═S)NH 2   
                 CF 3   
                 3,4,5-F 3   
               
               
                   
                 M.634. 
                 C(═S)NH 2   
                 CF 3   
                 2,4,6-F 3   
               
               
                   
                 M.635. 
                 C(═S)NH 2   
                 CF 3   
                 2-F, 3-Cl 
               
               
                   
                 M.636. 
                 C(═S)NH 2   
                 CF 3   
                 2-Cl, 4-F 
               
               
                   
                 M.637. 
                 C(═S)NH 2   
                 CF 3   
                 2-F, 3-CF 3   
               
               
                   
                 M.638. 
                 C(═S)NH 2   
                 CF 3   
                 2-F, 4-CF 3   
               
               
                   
                 M.639. 
                 C(═S)NH 2   
                 CF 3   
                 2-F, 5-CF 3   
               
               
                   
                 M.640. 
                 C(═S)NH 2   
                 CF 3   
                 3-F, 4-CF 3   
               
               
                   
                 M.641. 
                 C(═S)NH 2   
                 CF 3   
                 3-F, 5-CF 3   
               
               
                   
                 M.642. 
                 C(═S)NH 2   
                 CF 3   
                 4-F, 3-CF 3   
               
               
                   
                 M.643. 
                 C(═S)NH 2   
                 CF 3   
                 3,4-F 2 , 5-CF 3   
               
               
                   
                 M.644. 
                 C(═S)NH 2   
                 CF 3   
                 2-Cl, 3-CF 3   
               
               
                   
                 M.645. 
                 C(═S)NH 2   
                 CF 3   
                 2-Cl, 4-CF 3   
               
               
                   
                 M.646. 
                 C(═S)NH 2   
                 CF 3   
                 2-Cl, 5-CF 3   
               
               
                   
                 M.647. 
                 C(═S)NH 2   
                 CF 3   
                 3-Cl, 5-CF 3   
               
               
                   
                 M.648. 
                 C(═S)NH 2   
                 CF 3   
                 4-Cl, 3-CF 3   
               
               
                   
                 M.649. 
                 C(═S)NH 2   
                 CHF 2   
                 — 
               
               
                   
                 M.650. 
                 C(═S)NH 2   
                 CHF 2   
                 2-F 
               
               
                   
                 M.651. 
                 C(═S)NH 2   
                 CHF 2   
                 3-F 
               
               
                   
                 M.652. 
                 C(═S)NH 2   
                 CHF 2   
                 4-F 
               
               
                   
                 M.653. 
                 C(═S)NH 2   
                 CHF 2   
                 2-Cl 
               
               
                   
                 M.654. 
                 C(═S)NH 2   
                 CHF 2   
                 3-Cl 
               
               
                   
                 M.655. 
                 C(═S)NH 2   
                 CHF 2   
                 4-Cl 
               
               
                   
                 M.656. 
                 C(═S)NH 2   
                 CHF 2   
                 2-Br 
               
               
                   
                 M.657. 
                 C(═S)NH 2   
                 CHF 2   
                 3-Br 
               
               
                   
                 M.658. 
                 C(═S)NH 2   
                 CHF 2   
                 4-Br 
               
               
                   
                 M.659. 
                 C(═S)NH 2   
                 CHF 2   
                 2-CH 3   
               
               
                   
                 M.660. 
                 C(═S)NH 2   
                 CHF 2   
                 3-CH 3   
               
               
                   
                 M.661. 
                 C(═S)NH 2   
                 CHF 2   
                 4-CH 3   
               
               
                   
                 M.662. 
                 C(═S)NH 2   
                 CHF 2   
                 2-CF 3   
               
               
                   
                 M.663. 
                 C(═S)NH 2   
                 CHF 2   
                 3-CF 3   
               
               
                   
                 M.664. 
                 C(═S)NH 2   
                 CHF 2   
                 4-CF 3   
               
               
                   
                 M.665. 
                 C(═S)NH 2   
                 CHF 2   
                 2-OCF 3   
               
               
                   
                 M.666. 
                 C(═S)NH 2   
                 CHF 2   
                 3-OCF 3   
               
               
                   
                 M.667. 
                 C(═S)NH 2   
                 CHF 2   
                 4-OCF 3   
               
               
                   
                 M.668. 
                 C(═S)NH 2   
                 CHF 2   
                 2-SCF 3   
               
               
                   
                 M.669. 
                 C(═S)NH 2   
                 CHF 2   
                 3-SCF 3   
               
               
                   
                 M.670. 
                 C(═S)NH 2   
                 CHF 2   
                 4-SCF 3   
               
               
                   
                 M.671. 
                 C(═S)NH 2   
                 CHF 2   
                 2-CN 
               
               
                   
                 M.672. 
                 C(═S)NH 2   
                 CHF 2   
                 3-CN 
               
               
                   
                 M.673. 
                 C(═S)NH 2   
                 CHF 2   
                 4-CN 
               
               
                   
                 M.674. 
                 C(═S)NH 2   
                 CHF 2   
                 4-SO 2 CH 3   
               
               
                   
                 M.675. 
                 C(═S)NH 2   
                 CHF 2   
                 2,3-F 2   
               
               
                   
                 M.676. 
                 C(═S)NH 2   
                 CHF 2   
                 2,4-F 2   
               
               
                   
                 M.677. 
                 C(═S)NH 2   
                 CHF 2   
                 2,5-F 2   
               
               
                   
                 M.678. 
                 C(═S)NH 2   
                 CHF 2   
                 2,6-F 2   
               
               
                   
                 M.679. 
                 C(═S)NH 2   
                 CHF 2   
                 3,4-F 2   
               
               
                   
                 M.680. 
                 C(═S)NH 2   
                 CHF 2   
                 3,5-F 2   
               
               
                   
                 M.681. 
                 C(═S)NH 2   
                 CHF 2   
                 2,4-Cl 2   
               
               
                   
                 M.682. 
                 C(═S)NH 2   
                 CHF 2   
                 2,5-Cl 2   
               
               
                   
                 M.683. 
                 C(═S)NH 2   
                 CHF 2   
                 3,4-Cl 2   
               
               
                   
                 M.684. 
                 C(═S)NH 2   
                 CHF 2   
                 2,3,4-F 3   
               
               
                   
                 M.685. 
                 C(═S)NH 2   
                 CHF 2   
                 2,3,5-F 3   
               
               
                   
                 M.686. 
                 C(═S)NH 2   
                 CHF 2   
                 2,3,6-F 3   
               
               
                   
                 M.687. 
                 C(═S)NH 2   
                 CHF 2   
                 3,4,5-F 3   
               
               
                   
                 M.688. 
                 C(═S)NH 2   
                 CHF 2   
                 2,4,6-F 3   
               
               
                   
                 M.689. 
                 C(═S)NH 2   
                 CHF 2   
                 2-F, 3-Cl 
               
               
                   
                 M.690. 
                 C(═S)NH 2   
                 CHF 2   
                 2-Cl, 4-F 
               
               
                   
                 M.691. 
                 C(═S)NH 2   
                 CHF 2   
                 2-F, 3-CF 3   
               
               
                   
                 M.692. 
                 C(═S)NH 2   
                 CHF 2   
                 2-F, 4-CF 3   
               
               
                   
                 M.693. 
                 C(═S)NH 2   
                 CHF 2   
                 2-F, 5-CF 3   
               
               
                   
                 M.694. 
                 C(═S)NH 2   
                 CHF 2   
                 3-F, 4-CF 3   
               
               
                   
                 M.695. 
                 C(═S)NH 2   
                 CHF 2   
                 3-F, 5-CF 3   
               
               
                   
                 M.696. 
                 C(═S)NH 2   
                 CHF 2   
                 4-F, 3-CF 3   
               
               
                   
                 M.697. 
                 C(═S)NH 2   
                 CHF 2   
                 3,4-F 2 , 5-CF 3   
               
               
                   
                 M.698. 
                 C(═S)NH 2   
                 CHF 2   
                 2-Cl, 3-CF 3   
               
               
                   
                 M.699. 
                 C(═S)NH 2   
                 CHF 2   
                 2-Cl, 4-CF 3   
               
               
                   
                 M.700. 
                 C(═S)NH 2   
                 CHF 2   
                 2-Cl, 5-CF 3   
               
               
                   
                 M.701. 
                 C(═S)NH 2   
                 CHF 2   
                 3-Cl, 5-CF 3   
               
               
                   
                 M.702. 
                 C(═S)NH 2   
                 CHF 2   
                 4-Cl, 3-CF 3   
               
               
                   
                 M.703. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 — 
               
               
                   
                 M.704. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2-F 
               
               
                   
                 M.705. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 3-F 
               
               
                   
                 M.706. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 4-F 
               
               
                   
                 M.707. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2-Cl 
               
               
                   
                 M.708. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 3-Cl 
               
               
                   
                 M.709. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 4-Cl 
               
               
                   
                 M.710. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2-Br 
               
               
                   
                 M.711. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 3-Br 
               
               
                   
                 M.712. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 4-Br 
               
               
                   
                 M.713. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2-CH 3   
               
               
                   
                 M.714. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 3-CH 3   
               
               
                   
                 M.715. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 4-CH 3   
               
               
                   
                 M.716. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2-CF 3   
               
               
                   
                 M.717. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 3-CF 3   
               
               
                   
                 M.718. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 4-CF 3   
               
               
                   
                 M.719. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2-OCF 3   
               
               
                   
                 M.720. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 3-OCF 3   
               
               
                   
                 M.721. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 4-OCF 3   
               
               
                   
                 M.722. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2-SCF 3   
               
               
                   
                 M.723. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 3-SCF 3   
               
               
                   
                 M.724. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 4-SCF 3   
               
               
                   
                 M.725. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2-CN 
               
               
                   
                 M.726. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 3-CN 
               
               
                   
                 M.727. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 4-CN 
               
               
                   
                 M.728. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 4-SO 2 CH 3   
               
               
                   
                 M.729. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2,3-F 2   
               
               
                   
                 M.730. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2,4-F 2   
               
               
                   
                 M.731. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2,5-F 2   
               
               
                   
                 M.732. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2,6-F 2   
               
               
                   
                 M.733. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 3,4-F 2   
               
               
                   
                 M.734. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 3,5-F 2   
               
               
                   
                 M.735. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2,4-Cl 2   
               
               
                   
                 M.736. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2,5-Cl 2   
               
               
                   
                 M.737. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 3,4-Cl 2   
               
               
                   
                 M.738. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2,3,4-F 3   
               
               
                   
                 M.739. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2,3,5-F 3   
               
               
                   
                 M.740. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2,3,6-F 3   
               
               
                   
                 M.741. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 3,4,5-F 3   
               
               
                   
                 M.742. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2,4,6-F 3   
               
               
                   
                 M.743. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2-F, 3-Cl 
               
               
                   
                 M.744. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2-Cl, 4-F 
               
               
                   
                 M.745. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2-F, 3-CF 3   
               
               
                   
                 M.746. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2-F, 4-CF 3   
               
               
                   
                 M.747. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2-F, 5-CF 3   
               
               
                   
                 M.748. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 3-F, 4-CF 3   
               
               
                   
                 M.749. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 3-F, 5-CF 3   
               
               
                   
                 M.750. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 4-F, 3-CF 3   
               
               
                   
                 M.751. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 3,4-F 2 , 5-CF 3   
               
               
                   
                 M.752. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2-Cl, 3-CF 3   
               
               
                   
                 M.753. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2-Cl, 4-CF 3   
               
               
                   
                 M.754. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 2-Cl, 5-CF 3   
               
               
                   
                 M.755. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 3-Cl, 5-CF 3   
               
               
                   
                 M.756. 
                 C(═S)NH 2   
                 CF 2 CF 3   
                 4-Cl, 3-CF 3   
               
               
                   
                 M.757. 
                 C(═S)NH 2   
                 OCH 3   
                 — 
               
               
                   
                 M.758. 
                 C(═S)NH 2   
                 OCH 3   
                 2-F 
               
               
                   
                 M.759. 
                 C(═S)NH 2   
                 OCH 3   
                 3-F 
               
               
                   
                 M.760. 
                 C(═S)NH 2   
                 OCH 3   
                 4-F 
               
               
                   
                 M.761. 
                 C(═S)NH 2   
                 OCH 3   
                 2-Cl 
               
               
                   
                 M.762. 
                 C(═S)NH 2   
                 OCH 3   
                 3-Cl 
               
               
                   
                 M.763. 
                 C(═S)NH 2   
                 OCH 3   
                 4-Cl 
               
               
                   
                 M.764. 
                 C(═S)NH 2   
                 OCH 3   
                 2-Br 
               
               
                   
                 M.765. 
                 C(═S)NH 2   
                 OCH 3   
                 3-Br 
               
               
                   
                 M.766. 
                 C(═S)NH 2   
                 OCH 3   
                 4-Br 
               
               
                   
                 M.767. 
                 C(═S)NH 2   
                 OCH 3   
                 2-CH 3   
               
               
                   
                 M.768. 
                 C(═S)NH 2   
                 OCH 3   
                 3-CH 3   
               
               
                   
                 M.769. 
                 C(═S)NH 2   
                 OCH 3   
                 4-CH 3   
               
               
                   
                 M.770. 
                 C(═S)NH 2   
                 OCH 3   
                 2-CF 3   
               
               
                   
                 M.771. 
                 C(═S)NH 2   
                 OCH 3   
                 3-CF 3   
               
               
                   
                 M.772. 
                 C(═S)NH 2   
                 OCH 3   
                 4-CF 3   
               
               
                   
                 M.773. 
                 C(═S)NH 2   
                 OCH 3   
                 2-OCF 3   
               
               
                   
                 M.774. 
                 C(═S)NH 2   
                 OCH 3   
                 3-OCF 3   
               
               
                   
                 M.775. 
                 C(═S)NH 2   
                 OCH 3   
                 4-OCF 3   
               
               
                   
                 M.776. 
                 C(═S)NH 2   
                 OCH 3   
                 2-SCF 3   
               
               
                   
                 M.777. 
                 C(═S)NH 2   
                 OCH 3   
                 3-SCF 3   
               
               
                   
                 M.778. 
                 C(═S)NH 2   
                 OCH 3   
                 4-SCF 3   
               
               
                   
                 M.779. 
                 C(═S)NH 2   
                 OCH 3   
                 2-CN 
               
               
                   
                 M.780. 
                 C(═S)NH 2   
                 OCH 3   
                 3-CN 
               
               
                   
                 M.781. 
                 C(═S)NH 2   
                 OCH 3   
                 4-CN 
               
               
                   
                 M.782. 
                 C(═S)NH 2   
                 OCH 3   
                 4-SO 2 CH 3   
               
               
                   
                 M.783. 
                 C(═S)NH 2   
                 OCH 3   
                 2,3-F 2   
               
               
                   
                 M.784. 
                 C(═S)NH 2   
                 OCH 3   
                 2,4-F 2   
               
               
                   
                 M.785. 
                 C(═S)NH 2   
                 OCH 3   
                 2,5-F 2   
               
               
                   
                 M.786. 
                 C(═S)NH 2   
                 OCH 3   
                 2,6-F 2   
               
               
                   
                 M.787. 
                 C(═S)NH 2   
                 OCH 3   
                 3,4-F 2   
               
               
                   
                 M.788. 
                 C(═S)NH 2   
                 OCH 3   
                 3,5-F 2   
               
               
                   
                 M.789. 
                 C(═S)NH 2   
                 OCH 3   
                 2,4-Cl 2   
               
               
                   
                 M.790. 
                 C(═S)NH 2   
                 OCH 3   
                 2,5-Cl 2   
               
               
                   
                 M.791. 
                 C(═S)NH 2   
                 OCH 3   
                 3,4-Cl 2   
               
               
                   
                 M.792. 
                 C(═S)NH 2   
                 OCH 3   
                 2,3,4-F 3   
               
               
                   
                 M.793. 
                 C(═S)NH 2   
                 OCH 3   
                 2,3,5-F 3   
               
               
                   
                 M.794. 
                 C(═S)NH 2   
                 OCH 3   
                 2,3,6-F 3   
               
               
                   
                 M.795. 
                 C(═S)NH 2   
                 OCH 3   
                 3,4,5-F 3   
               
               
                   
                 M.796. 
                 C(═S)NH 2   
                 OCH 3   
                 2,4,6-F 3   
               
               
                   
                 M.797. 
                 C(═S)NH 2   
                 OCH 3   
                 2-F, 3-Cl 
               
               
                   
                 M.798. 
                 C(═S)NH 2   
                 OCH 3   
                 2-Cl, 4-F 
               
               
                   
                 M.799. 
                 C(═S)NH 2   
                 OCH 3   
                 2-F, 3-CF 3   
               
               
                   
                 M.800. 
                 C(═S)NH 2   
                 OCH 3   
                 2-F, 4-CF 3   
               
               
                   
                 M.801. 
                 C(═S)NH 2   
                 OCH 3   
                 2-F, 5-CF 3   
               
               
                   
                 M.802. 
                 C(═S)NH 2   
                 OCH 3   
                 3-F, 4-CF 3   
               
               
                   
                 M.803. 
                 C(═S)NH 2   
                 OCH 3   
                 3-F, 5-CF 3   
               
               
                   
                 M.804. 
                 C(═S)NH 2   
                 OCH 3   
                 4-F, 3-CF 3   
               
               
                   
                 M.805. 
                 C(═S)NH 2   
                 OCH 3   
                 3,4-F 2 , 5-CF 3   
               
               
                   
                 M.806. 
                 C(═S)NH 2   
                 OCH 3   
                 2-Cl, 3-CF 3   
               
               
                   
                 M.807. 
                 C(═S)NH 2   
                 OCH 3   
                 2-Cl, 4-CF 3   
               
               
                   
                 M.808. 
                 C(═S)NH 2   
                 OCH 3   
                 2-Cl, 5-CF 3   
               
               
                   
                 M.809. 
                 C(═S)NH 2   
                 OCH 3   
                 3-Cl, 5-CF 3   
               
               
                   
                 M.810. 
                 C(═S)NH 2   
                 OCH 3   
                 4-Cl, 3-CF 3   
               
               
                   
                 M.811. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 — 
               
               
                   
                 M.812. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2-F 
               
               
                   
                 M.813. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 3-F 
               
               
                   
                 M.814. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 4-F 
               
               
                   
                 M.815. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2-Cl 
               
               
                   
                 M.816. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 3-Cl 
               
               
                   
                 M.817. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 4-Cl 
               
               
                   
                 M.818. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2-Br 
               
               
                   
                 M.819. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 3-Br 
               
               
                   
                 M.820. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 4-Br 
               
               
                   
                 M.821. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2-CH 3   
               
               
                   
                 M.822. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 3-CH 3   
               
               
                   
                 M.823. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 4-CH 3   
               
               
                   
                 M.824. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2-CF 3   
               
               
                   
                 M.825. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 3-CF 3   
               
               
                   
                 M.826. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 4-CF 3   
               
               
                   
                 M.827. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2-OCF 3   
               
               
                   
                 M.828. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 3-OCF 3   
               
               
                   
                 M.829. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 4-OCF 3   
               
               
                   
                 M.830. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2-SCF 3   
               
               
                   
                 M.831. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 3-SCF 3   
               
               
                   
                 M.832. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 4-SCF 3   
               
               
                   
                 M.833. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2-CN 
               
               
                   
                 M.834. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 3-CN 
               
               
                   
                 M.835. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 4-CN 
               
               
                   
                 M.836. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 4-SO 2 CH 3   
               
               
                   
                 M.837. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2,3-F 2   
               
               
                   
                 M.838. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2,4-F 2   
               
               
                   
                 M.839. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2,5-F 2   
               
               
                   
                 M.840. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2,6-F 2   
               
               
                   
                 M.841. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 3,4-F 2   
               
               
                   
                 M.842. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 3,5-F 2   
               
               
                   
                 M.843. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2,4-Cl 2   
               
               
                   
                 M.844. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2,5-Cl 2   
               
               
                   
                 M.845. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 3,4-Cl 2   
               
               
                   
                 M.846. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2,3,4-F 3   
               
               
                   
                 M.847. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2,3,5-F 3   
               
               
                   
                 M.848. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2,3,6-F 3   
               
               
                   
                 M.849. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 3,4,5-F 3   
               
               
                   
                 M.850. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2,4,6-F 3   
               
               
                   
                 M.851. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2-F, 3-Cl 
               
               
                   
                 M.852. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2-Cl, 4-F 
               
               
                   
                 M.853. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2-F, 3-CF 3   
               
               
                   
                 M.854. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2-F, 4-CF 3   
               
               
                   
                 M.855. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2-F, 5-CF 3   
               
               
                   
                 M.856. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 3-F, 4-CF 3   
               
               
                   
                 M.857. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 3-F, 5-CF 3   
               
               
                   
                 M.858. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 4-F, 3-CF 3   
               
               
                   
                 M.859. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 3,4-F 2 , 5-CF 3   
               
               
                   
                 M.860. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2-Cl, 3-CF 3   
               
               
                   
                 M.861. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2-Cl, 4-CF 3   
               
               
                   
                 M.862. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 2-Cl, 5-CF 3   
               
               
                   
                 M.863. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 3-Cl, 5-CF 3   
               
               
                   
                 M.864. 
                 C(═S)NH 2   
                 OCH 2 CH 3   
                 4-Cl, 3-CF 3   
               
               
                   
                   
               
            
           
         
       
     
     Table 1: This table discloses the 864 compounds 1.1 to 1.864 of the formula (I-a), wherein Y is 5-methyl-1,2,4-oxadiazole-3-yl, X is hydrogen and R 1 , R 3 , and R 6  are as defined in Table M. For example, compound No. 1.1 has the following structure: 
     
       
         
         
             
             
         
       
     
     Table 2: This table discloses the 864 compounds 2.1 to 2.864 of the formula (I-a), wherein Y is 1-methyl-1,2,4-triazole-3-yl, X is hydrogen and R 1 , R 3 , and R 6  are as defined in Table M. 
     Table 3: This table discloses the 864 compounds 3.1 to 3.864 of the formula (I-a), wherein Y is 3,5-dichloropyridine-2-yl, X is hydrogen and R 1 , R 3 , and R 6  are as defined in Table M. 
     Table 4: This table discloses the 864 compounds 4.1 to 4.864 of the formula (I-a), wherein Y is 3-chloro-5-(trifluoromethyl)pyridine-2-yl, X is hydrogen and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 5: This table discloses the 864 compounds 5.1 to 5.864 of the formula (I-a), wherein Y is phenyl, X is hydrogen and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 6: This table discloses the 864 compounds 6.1 to 6.864 of the formula (I-a), wherein Y is phenyl, X is hydroxy and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 7: This table discloses the 864 compounds 7.1 to 7.864 of the formula (I-a), wherein Y is 4-chloro-phenyl-1-yl, X is hydrogen and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 8: This table discloses the 864 compounds 8.1 to 8.864 of the formula (I-a), wherein Y is 4-chloro-phenyl-1-yl, X is hydroxyl and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 9: This table discloses the 864 compounds 9.1 to 9.864 of the formula (I-a), wherein Y is methylsulfanylmethyl, X is hydrogen and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 10: This table discloses the 864 compounds 10.1 to 10.864 of the formula (I-a), wherein Y is methylsulfinylmethyl, X is hydrogen and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 11: This table discloses the 84 compounds 11.1 to 11.864 of the formula (I-a), wherein Y is methylsulfonylmethyl, X is hydrogen and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 12: This table discloses the 864 compounds 12.1 to 12.864 of the formula (I-a), wherein Y is ethylsulfanylmethyl, X is hydrogen and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 13: This table discloses the 864 compounds 13.1 to 13.864 of the formula (I-a), wherein Y is ethylsulfinylmethyl, X is hydrogen and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 14: This table discloses the 864 compounds 14.1 to 14.864 of the formula (I-a), wherein Y is ethylsulfonylmethyl, X is hydrogen and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 15: This table discloses the 864 compounds 15.1 to 15.864 of the formula (I-a), wherein Y is 1,1-dioxo-1,2-thiazolidin-2-yl, X is hydrogen and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 16: This table discloses the 864 compounds 16.1 to 16.864 of the formula (I-a), wherein Y is (E)-methoxyiminomethyl, X is hydrogen and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 17: This table discloses the 864 compounds 17.1 to 17.864 of the formula (I-a), wherein Y is (E)-ethoxyiminomethyl, X is hydrogen and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 18: This table discloses the 864 compounds 18.1 to 18.864 of the formula (I-a), wherein Y is N,N-dimethyl-carboxamide, X is hydrogen and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 19: This table discloses the 864 compounds 19.1 to 19.864 of the formula (I-a), wherein Y is methanesulfonamido, X is hydrogen and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 20: This table discloses the 864 compounds 20.1 to 20.864 of the formula (I-a), wherein Y is cyano, X is hydrogen and R 1 , R 3  and R 6  are as defined in Table M. 
     Specific examples of compounds of the present invention are represented by the formula (I-b) in the following Tables 21 to 35: 
     
       
         
         
             
             
         
       
     
     wherein R 1 , R 3  and Rr are as defined above in table M. 
     Each of Tables 21 to 35 below, comprises 864 compounds of the formula (I-b) in which R 1 , R 3  and R 6  have the values given in each row in Table M, and A has the values given in the relevant Tables 21 to 35. Thus compound 21.1 corresponds to a compound of formula (I-b) where R 1 , R 3  and R 6  are as defined in row 1 of Table M and where A is as defined in Table 21; compound 30.14 corresponds to a compound of formula (I-b) where R 1 , R 3  and R 6  are as defined in row 14 of Table M and where A is as defined in Table 30; and so on. 
     Table 21: This table discloses the 864 compounds 21.1 to 21.864 of the formula (I-b), wherein A is 3,5-dichloropyridine-2-yl, and R 1 , R 3  and R 6  are as defined in Table M. For example, compound No. 1.1 has the following structure: 
     
       
         
         
             
             
         
       
     
     Table 22: This table discloses the 864 compounds 22.1 to 22.864 of the formula (I-b), wherein A is 3-chloro-5-(trifluoromethyl)pyridine-2-yl, and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 23: This table discloses the 864 compounds 23.1 to 23.864 of the formula (I-b), wherein A is 3-chloro-pyridine-2-yl, and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 24: This table discloses the 864 compounds 24.1 to 24 864 of the formula (I-b), wherein A is cyano, and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 25: This table discloses the 864 compounds 25.1 to 25.864 of the formula (I-b), wherein A is cyanomethyl and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 26: This table discloses the 864 compounds 26.1 to 6.864 of the formula (I-b), wherein A is cyanoethyl, and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 27: This table discloses the 864 compounds 27.1 to 27.864 of the formula (I-b), wherein A is 2,2,2-trifluoroethyl, and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 28: This table discloses the 864 compounds 28.1 to 28.864 of the formula (I-b), wherein A is vinyloxycarbonyl, and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 29: This table discloses the 864 compounds 29.1 to 29.864 of the formula (I-b), wherein A is tert.butyloxycarbonyl and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 30: This table discloses the 864 compounds 30.1 to 30.864 of the formula (I-b), wherein A is 4-fluoro-phenyl, and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 31: This table discloses the 84 compounds 31.1 to 31.864 of the formula (I-b), wherein A is 4-chloro-phenyl, and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 32: This table discloses the 864 compounds 32.1 to 32.864 of the formula (I-b), wherein A is 2,4-dichloro-phenyl, and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 33: This table discloses the 864 compounds 33.1 to 33.864 of the formula (I-b), wherein A is ethylsulfanylethyl, and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 34: This table discloses the 864 compounds 34.1 to 34.864 of the formula (I-b), wherein A is ethylsulfinylethyl, and R 1 , R 3  and R 6  are as defined in Table M. 
     Table 35: This table discloses the 864 compounds 35.1 to 35.864 of the formula (I-b), wherein A is ethylsulfonylethyl, and R 1 , R 3  and R 6  are as defined in Table M. 
     Also made available are certain intermediate compounds of formulae III, V, VI, some of which are novel. 
     Accordingly, made available herein are:
         compounds of formulae III-a       

     
       
         
         
             
             
         
       
         
         
           
             wherein R 1 , R 3  and R 6  are defined in each row of Table M and R 4  is hydrogen or R 1 , R 3  and R 6  are defined in each row of Table M and R 4  is cyano; 
             compounds of V-a 
           
         
       
    
     
       
         
         
             
             
         
       
         
         
           
             wherein R 1 , R 3  and R 6  are defined in each row of Table M and R 4  is hydrogen or R 1 , R 3  and R 6  are defined in each row of Table M and R 4  is cyano; 
             compounds of VI-a 
           
         
       
    
     
       
         
         
             
             
         
       
         
         
           
             wherein R 1 , R 3  and R 6  are defined in each row of Table M, R 4  is hydrogen and R 12  is selected from methyl, ethyl, propyl, iso-propyl, butyl, iso-butyl and tert-butyl. or R 1 , R 3  and R 6  are defined in each row of Table M, R 4  is cyano and R 12  is selected from methyl, ethyl, propyl, iso-propyl, butyl, iso-butyl and tert-butyl; 
             compounds of formula IV-Aa 
           
         
       
    
     
       
         
         
             
             
         
       
         
         
           
             wherein X and Y are as defined in any one of Tables 1 to 20; and compounds of formula IV-ba 
           
         
       
    
     
       
         
         
             
             
         
       
     
     Wherein A is as defined in any one of Tables 21 to 35. 
     In further aspect, the present invention accordingly makes available compounds of formulae III, V and VI, wherein in each case, R 1 , R 2 , R 3 , R 4  and R 5  are as defined for formula I in the first aspect, and R 12  for formula VI, is C 1 -C 6 -alkyl. Furthermore, the corresponding embodiments for R 1 , R 2 , R 3 , R 4  and R 5  illustrated for formula I also apply to the compounds of formulae III, V and VI. R 12 , for formula VI, is preferably methyl, ethyl, or propyl; more preferably methyl. 
     The compounds of formula (I) according to the invention are preventively and/or curatively valuable active ingredients in the field of pest control, even at low rates of application, which have a very favorable biocidal spectrum and are well tolerated by warm-blooded species, fish and plants. The active ingredients according to the invention act against all or individual developmental stages of normally sensitive, but also resistant, animal pests, such as insects or representatives of the order  Acarina . The insecticidal or acaricidal activity of the active ingredients according to the invention can manifest itself directly, i. e. in destruction of the pests, which takes place either immediately or only after some time has elapsed, for example during ecdysis, or indirectly, for example in a reduced oviposition and/or hatching rate. 
     Examples of the above mentioned animal pests are: 
     from the order  Acarina , for example,  Acalitus  spp,  Aculus  spp,  Acaricalus  spp,  Aceria  spp,  Acarus siro, Amblyomma  spp.,  Argas  spp.,  Boophilus  spp.,  Brevipalpus  spp.,  Bryobia  spp,  Calipitrimerus  spp.,  Chorioptes  spp.,  Dermanyssus gallinae, Dermatophagoides  spp,  Eotetranychus  spp,  Eriophyes  spp.,  Hemitarsonemus  spp,  Hyalomma  spp.,  Ixodes  spp.,  Olygonychus  spp,  Ornithodoros  spp.,  Polyphagotarsone latus, Panonychus  spp.,  Phyllocoptruta oleivora, Phytonemus  spp,  Polyphagotarsonemus  spp,  Psoroptes  spp.,  Rhipicephalus  spp.,  Rhizoglyphus  spp.,  Sarcoptes  spp.,  Steneotarsonemus  spp,  Tarsonemus  spp. and  Tetranychus  spp.; 
     from the order  Anoplura , for example, 
       Haematopinus  spp.,  Linognathus  spp.,  Pediculus  spp.,  Pemphigus  spp. and  Phylloxera  spp.; 
     from the order  Coleoptera , for example, 
       Agriotes  spp.,  Amphimallon majale, Anomala orientalis, Anthonomus  spp.,  Aphodius  spp,  Astylus atromaculatus, Ataenius  spp,  Atomaria linearis, Chaetocnema tibialis, Cerotoma  spp,  Conoderus  spp,  Cosmopolites  spp.,  Cotinis nitida, Curculio  spp.,  Cyclocephala  spp,  Dermestes  spp.,  Diabrotica  spp.,  Diloboderus abderus, Epilachna  spp.,  Eremnus  spp.,  Heteronychus arator, Hypothenemus hampei, Lagria vilosa, Leptinotarsa decemlineata, Lissorhoptrus  spp.,  Liogenys  spp,  Maecolaspis  spp,  Maladera castanea, Megascelis  spp,  Melighetes aeneus, Melolontha  spp.,  Myochrous armatus, Orycaephilus  spp.,  Otiorhynchus  spp.,  Phyllophaga  spp,  Phlyctinus  spp.,  Popillia  spp.,  Psylliodes  spp.,  Rhyssomatus aubtilis, Rhizopertha  spp.,  Scarabeidae, Sitophilus  spp.,  Sitotroga  spp.,  Somaticus  spp,  Sphenophorus  spp,  Sternechus subsignatus, Tenebrio  spp.,  Tribolium  spp. and  Trogoderma  spp.; 
     from the order  Diptera , for example,  Aedes  spp.,  Anopheles  spp,  Antherigona soccata, Bactrocea oleae, Bibio hortulanus, Bradysia  spp,  Calliphora erythrocephala, Ceratitis  spp.,  Chrysomyia  spp.,  Culex  spp.,  Cuterebra  spp.,  Dacus  spp.,  Delia  spp,  Drosophila melanogaster, Fannia  spp.,  Gastrophilus  spp.,  Geomyza tripunctata, Glossina  spp.,  Hypoderma  spp.,  Hyppobosca  spp.,  Liriomyza  spp.,  Lucilia  spp.,  Melanagromyza  spp.,  Musca  spp.,  Oestrus  spp.,  Orseolia  spp.,  Oscinella frit, Pegomyia hyoscyami, Phorbia  spp.,  Rhagoletis  spp,  Rivelia quadrifasciata, Scatella  spp,  Sciara  spp.,  Stomoxys  spp.,  Tabanus  spp.,  Tannia  spp. and  Tipula  spp.; 
     from the order  Hemiptera , for example, 
       Acanthocoris scabrator, Acrosternum  spp,  Adelphocoris lineolatus, Aleurodes  spp.,  Amblypelta nitida, Bathycoelia thalassina, Blissus  spp,  Cimex  spp.,  Clavigralla tomentosicollis, Creontiades  spp,  Distantiella theobroma, Dichelops furcatus, Dysdercus  spp.,  Edessa  spp,  Euchistus  spp.,  Eurydema pulchrum, Eurygaster  spp.,  Halyomorpha halys, Horcias nobilellus, Leptocorisa  spp.,  Lygus  spp,  Margarodes  spp,  Murgantia histrionic, Neomegalotomus  spp,  Nesidiocoris tenuis, Nezara  spp.,  Nysius simulans, Oebalus insularis, Piesma  spp.,  Piezodorus  spp,  Rhodnius  spp.,  Sahlbergella singularis, Scaptocoris castanea, Scotinophara  spp.,  Thyanta  spp,  Triatoma  spp.,  Vatiga illudens; Acyrthosium pisum, Adalges  spp,  Agalliana ensigera, Agonoscena targionii, Aleurodicus  spp,  Aleurocanthus  spp,  Aleurolobus barodensis, Aleurothrixus floccosus, Aleyrodes brassicae, Amarasca biguttula, Amritodus atkinsoni, Aonidiella  spp.,  Aphididae, Aphis  spp.,  Aspidiotus  spp.,  Aulacorthum solani, Bactericera cockerelli, Bemisia  spp,  Brachycaudus  spp,  Brevicoryne brassicae, Cacopsylla  spp,  Cavariella aegopodii  Scop.,  Ceroplaster  spp.,  Chrysomphalus aonidium, Chrysomphalus dictyospermi, Cicadella  spp,  Cofana spectra, Cryptomyzus  spp,  Cicadulina  spp,  Coccus hesperidum, Dalbulus maidis, Dialeurodes  spp,  Diaphorina citri, Diuraphis noxia, Dysaphis  spp,  Empoasca  spp.,  Eriosoma larigerum, Erythroneura  spp.,  Gascardia  spp.,  Glycaspis brimblecombei, Hyadaphis pseudobrassicae, Hyalopterus  spp,  Hyperomyzus pallidus, Idioscopus clypealis, Jacobiasca lybica, Laodelphax  spp.,  Lecanium corni, Lepidosaphes  spp.,  Lopaphis erysimi, Lyogenys maidis, Macrosiphum  spp.,  Mahanarva  spp,  Metcalfa pruinosa, Metopolophium dirhodum, Myndus crudus, Myzus  spp.,  Neotoxoptera  sp,  Nephotettix  spp.,  Nilaparvata  spp.,  Nippolachnus piri  Mats,  Odonaspis ruthae, Oregma lanigera Zehnter, Parabemisia myricae, Paratrioza cockerelli, Parlatoria  spp.,  Pemphigus  spp.,  Peregrinus maidis, Perkinsiella  spp,  Phorodon humuli, Phylloxera  spp,  Planococcus  spp.,  Pseudaulacaspis  spp.,  Pseudococcus  spp.,  Pseudatomoscelis seriatus, Psylla  spp.,  Pulvinaria aethiopica, Quadraspidiotus  spp.,  Quesada gigas, Recilia dorsalis, Rhopalosiphum  spp.,  Saissetia  spp.,  Scaphoideus  spp.,  Schizaphis  spp.,  Sitobion  spp.,  Sogatella furcifera, Spissistilus festinus, Tarophagus Proserpina, Toxoptera  spp,  Trialeurodes  spp,  Tridiscus sporoboli, Trionymus  spp,  Trioza erytreae, Unaspis citri, Zygina flammigera, Zyginidia scutellaris;    
     from the order Hymenoptera, for example, 
       Acromyrmex, Arge  spp,  Atta  spp.,  Cephus  spp.,  Diprion  spp.,  Diprionidae, Gilpinia polytoma, Hoplocampa  spp.,  Lasius  spp.,  Monomorium pharaonis, Neodiprion  spp.,  Pogonomyrmex  spp,  Slenopsis invicta, Solenopsis  spp. and  Vespa  spp.; 
     from the order  Isoptera , for example, 
       Coptotermes  spp,  Corniternes cumulans, Incisitermes  spp,  Macrotermes  spp,  Mastotermes  spp,  Microtermes  spp,  Reticulitermes  spp.;  Solenopsis geminate    
     from the order  Lepidoptera , for example, 
       Acleris  spp.,  Adoxophyes  spp.,  Aegeria  spp.,  Agrotis  spp.,  Alabama argillaceae, Amylois  spp.,  Anticarsia gemmatalis, Archips  spp.,  Argyresthia  spp,  Argyrotaenia  spp.,  Autographa  spp.,  Bucculatrix thurberiella, Busseola fusca, Cadra cautella, Carposina nipponensis, Chilo  spp.,  Choristoneura  spp.,  Chrysoteuchia topiaria, Clysia ambiguella, Cnaphalocrocis  spp.,  Cnephasia  spp.,  Cochylis  spp.,  Coleophora  spp.,  Colias lesbia, Cosmophila flava, Crambus  spp,  Crocidolomia binotalis, Cryptophlebia leucotreta, Cydalima perspectalis, Cydia  spp.,  Diaphania perspectalis, Diatraea  spp.,  Diparopsis castanea, Earias  spp.,  Elasmopalpus lignosellus, Eldana saccharina, Ephestia  spp.,  Epinotia  spp,  Estigmene acrea, Etiella zinckinella, Eucosma  spp.,  Eupoecilia ambiguella, Euproctis  spp.,  Euxoa  spp.,  Feltia jaculiferia, Grapholita  spp.,  Hedya nubiferana, Heliothis  spp.,  Hellula undalis, Herpetogramma  spp,  Hyphantria cunea, Keiferia lycopersicella, Lasmopalpus lignosellus, Leucoptera scitella, Lithocollethis  spp.,  Lobesia botrana, Loxostege bifidalis, Lymantria  spp.,  Lyonetia  spp.,  Malacosoma  spp.,  Mamestra brassicae, Manduca sexta, Mythimna  spp,  Noctua  spp,  Operophtera  spp.,  Orniodes indica, Ostrinia nubilalis, Pammene  spp.,  Pandemis  spp.,  Panolis flammea, Papaipema nebris, Pectinophora gossypiela, Perileucoptera coffeella, Pseudaletia unipuncta, Phthorimaea operculella, Pieris rapae, Pieris  spp.,  Plutella xylostella, Prays  spp.,  Pseudoplusia  spp,  Rachiplusia nu, Richia albicosta, Scirpophaga  spp.,  Sesamia  spp.,  Sparganothis  spp.,  Spodoptera  spp.,  Sylepta  derogate,  Synanthedon  spp.,  Thaumetopoea  spp.,  Tortrix  spp.,  Trichoplusia ni, Tuta absoluta  and  Yponomeuta  spp.; 
     from the order  Mallophaga , for example, 
       Damalinea  spp. and  Trichodectes  spp.; 
     from the order Orthoptera, for example, 
       Blatta  spp.,  Blattella  spp.,  Gryllotalpa  spp.,  Leucophaea maderae, Locusta  spp.,  Neocurtilla hexadactyla, Periplaneta  spp.,  Scapteriscus  spp and  Schistocerca  spp.; 
     from the order Psocoptera, for example, 
       Liposcelis  spp.; 
     from the order  Siphonaptera , for example, 
       Ceratophyllus  spp.,  Ctenocephalides  spp. and  Xenopsylla cheopis;    
     from the order Thysanoptera, for example, 
       Calliothrips phaseoli, Frankliniella  spp.,  Heliothrips  spp,  Hercinothrips  spp.,  Parthenothrips  spp,  Scirtothrips aurantii, Sericothrips variabilis, Taeniothrips  spp.,  Thrips  spp; 
     from the order Thysanura, for example,  Lepisma saccharina.    
     In a further aspect, the invention may also relate to a method of controlling damage to plant and parts thereof by plant parasitic nematodes (Endoparasitic-, Semiendoparasitic- and Ectoparasitic nematodes), especially plant parasitic nematodes such as root knot nematodes,  Meloidogyne hapla, Meloidogyne incognita, Meloidogyne javanica, Meloidogyne arenaria  and other  Meloidogyne  species; cyst-forming nematodes,  Globodera rostochiensis  and other  Globodera  species;  Heterodera avenae, Heterodera glycines, Heterodera schachtii, Heterodera trifolii  and other  Heterodera  species; Seed gall nematodes,  Anguina  species; Stem and foliar nematodes,  Aphelenchoides  species; Sting nematodes,  Belonolaimus longicaudatus  and other  Belonolaimus  species; Pine nematodes,  Bursaphelenchus xylophilus  and other  Bursaphelenchus  species; Ring nematodes,  Criconema  species,  Criconemella  species,  Criconemoides  species,  Mesocriconema  species; Stem and bulb nematodes,  Ditylenchus destructor, Ditylenchus dipsaci  and other  Ditylenchus  species; Awl nematodes,  Dolichodorus  species; Spiral nematodes,  Heliocotylenchus multicinctus  and other  Helicotylenchus  species; Sheath and sheathoid nematodes,  Hemicycliophora  species and  Hemicriconemoides  species;  Hirshmanniella  species; Lance nematodes,  Hoploaimus  species; false rootknot nematodes,  Nacobbus  species; Needle nematodes,  Longidorus elongatus  and other  Longidorus  species; Pin nematodes,  Pratylenchus  species; Lesion nematodes,  Pratylenchus neglectus, Pratylenchus penetrans, Pratylenchus curvitatus, Pratylenchus goodeyi  and other  Pratylenchus  species; Burrowing nematodes,  Radopholus similis  and other  Radopholus  species; Reniform nematodes,  Rotylenchus robustus, Rotylenchus reniformis  and other  Rotylenchus  species;  Scutellonema  species; Stubby root nematodes,  Trichodorus primitivus  and other  Trichodorus  species,  Paratrichodorus  species; Stunt nematodes,  Tylenchorhynchus claytoni, Tylenchorhynchus dubius  and other  Tylenchorhynchus  species; Citrus nematodes,  Tylenchulus  species; Dagger nematodes,  Xiphinema  species; and other plant parasitic nematode species, such as  Subanguina  spp.,  Hypsoperine  spp.,  Macroposthonia  spp.,  Melinius  spp.,  Punctodera  spp. and  Quinisulcius  spp. 
     The compounds of the invention may also have activity against the molluscs. Examples of which include, for example,  Ampullariidae; Arion  ( A. ater, A. circumscriptus, A. hortensis, A. rufus );  Bradybaenidae  ( Bradybaena fruticum );  Cepaea  ( C. hortensis, C. Nemoralis );  ochlodina; Deroceras  ( D. agrestis, D. empiricorum, D. laeve, D. reticulatum );  Discus  ( D. rotundatus );  Euomphalia; Galba  ( G. trunculata );  Helicelia  ( H. itala, H. obvia );  Helicidae Helicigona arbustorum );  Helicodiscus; Helix  ( H. aperta );  Limax  ( L. cinereoniger, L. flavus, L. marginatus, L. maximus, L. tenellus );  Lymnaea; Milax  ( M. gagates, M. marginatus, M. sowerbyi );  Opeas; Pomacea  ( P. canaticulata );  Vallonia  and  Zanitoides.    
     The active ingredients according to the invention can be used for controlling, i. e. containing or destroying, pests of the abovementioned type which occur in particular on plants, especially on useful plants and ornamentals in agriculture, in horticulture and in forests, or on organs, such as fruits, flowers, foliage, stalks, tubers or roots, of such plants, and in some cases even plant organs which are formed at a later point in time remain protected against these pests. 
     Suitable target crops are, in particular, cereals, such as wheat, barley, rye, oats, rice, maize or sorghum; beet, such as sugar or fodder beet; fruit, for example pomaceous fruit, stone fruit or soft fruit, such as apples, pears, plums, peaches, almonds, cherries or berries, for example strawberries, raspberries or blackberries; leguminous crops, such as beans, lentils, peas or soya; oil crops, such as oilseed rape, mustard, poppies, olives, sunflowers, coconut, castor, cocoa or ground nuts; cucurbits, such as pumpkins, cucumbers or melons; fibre plants, such as cotton, flax, hemp orjute; citrus fruit, such as oranges, lemons, grapefruit or tangerines; vegetables, such as spinach, lettuce, asparagus, cabbages, carrots, onions, tomatoes, potatoes or bell peppers; Lauraceae, such as avocado, Cinnamonium or camphor; and also tobacco, nuts, coffee, eggplants, sugarcane, tea, pepper, grapevines, hops, the plantain family and latex plants. 
     In a particular embodiment, a compound of the formula (I) controls mites, rust mites and spider mites in crops, tress and plants selected from vegetables (especially tomatoes and cucurbits), citrus, pome fruits, stone fruit, tree nuts, cotton, tropical crops, avocados, ornamentals, beans, soybean, strawberry and grapes. 
     The compositions and/or methods of the present invention may be also used on any ornamental and/or vegetable crops, including flowers, shrubs, broad-leaved trees and evergreens. 
     For example the invention may be used on any of the following ornamental species:  Ageratum  spp.,  Alonsoa  spp.,  Anemone  spp.,  Anisodontea capsenisis, Anthemis  spp.,  Antirrhinum  spp.,  Aster  spp.,  Begonia  spp. (e.g.  B. elatior, B. semperflorens, B. tubereux ),  Bougainvillea  spp.,  Brachycome  spp.,  Brassica  spp. (ornamental),  Calceolaria  spp.,  Capsicum annuum, Catharanthus roseus, Canna  spp.,  Centaurea  spp.,  Chrysanthemum  spp.,  Cineraria  spp. ( C. maritime ),  Coreopsis  spp.,  Crassula coccinea, Cuphea ignea, Dahlia  spp.,  Delphinium  spp.,  Dicentra spectabilis, Dorotheantus  spp.,  Eustoma grandiflorum, Forsythia  spp.,  Fuchsia  spp.,  Geranium gnaphalium, Gerbera  spp.,  Gomphrena globosa, Heliotropium  spp.,  Helianthus  spp.,  Hibiscus  spp.,  Hortensia  spp.,  Hydrangea  spp.,  Hypoestes phyllostachya, Impatiens  spp. (I.  Walleriana ),  Iresines  spp.,  Kalanchoe  spp.,  Lantana camara, Lavatera trimestris, Leonotis leonurus, Lilium  spp.,  Mesembryanthemum  spp.,  Mimulus  spp.,  Monarda  spp.,  Nemesia  spp.,  Tagetes  spp.,  Dianthus  spp. (carnation),  Canna  spp.,  Oxalis  spp.,  Bellis  spp.,  Pelargonium  spp. ( P. peltatum, P. Zonale ),  Viola  spp. (pansy),  Petunia  spp.,  Phlox  spp.,  Plecthranthus  spp.,  Poinsettia  spp.,  Parthenocissus  spp. ( P. quinquefolia, P. tricuspidata ),  Primula  spp.,  Ranunculus  spp.,  Rhododendron  spp.,  Rosa  spp. (rose),  Rudbeckia  spp.,  Saintpaulia  spp.,  Salvia  spp.,  Scaevola aemola, Schizanthus wisetonensis, Sedum  spp.,  Solanum  spp.,  Surfinia  spp.,  Tagetes  spp.,  Nicotinia  spp.,  Verbena  spp.,  Zinnia  spp. and other bedding plants. 
     For example the invention may be used on any of the following vegetable species:  Allium  spp. ( A. sativum, A. cepa, A. oschaninii, A. Porrum, A. ascalonicum, A. fistulosum ),  Anthriscus cerefolium, Apium graveolus, Asparagus officinalis, Beta vulgarus, Brassica  spp. ( B. Oleracea, B. Pekinensis, B. rapa ),  Capsicum annuum, Cicer arietinum, Cichorium endivia, Cichorum  spp. ( C. intybus, C. endivia ),  Citrillus lanatus, Cucumis  spp. ( C. sativus, C. melo ),  Cucurbita  spp. ( C. pepo, C. maxima ),  Cyanara  spp. ( C. scolymus, C. cardunculus ),  Daucus carota, Foeniculum vulgare, Hypericum  spp.,  Lactuca sativa, Lycopersicon  spp. ( L. esculentum, L. lycopersicum ),  Mentha  spp.,  Ocimum basilicum, Petroselinum crispum, Phaseolus  spp. ( P. vulgaris, P. coccineus ),  Pisum sativum, Raphanus sativus, Rheum rhaponticum, Rosemarinus  spp.,  Salvia  spp.,  Scorzonera hispanica, Solanum melongena, Spinacea oleracea, Valerianella  spp. ( V. locusta, V. eriocarpa ) and  Vicia faba.    
     Preferred ornamental species include African violet,  Begonia, Dahlia, Gerbera, Hydrangea, Verbena, Rosa, Kalanchoe, Poinsettia, Aster, Centaurea, Coreopsis, Delphinium, Monarda, Phlox, Rudbeckia, Sedum, Petunia, Viola, Impatiens, Geranium, Chrysanthemum, Ranunculus, Fuchsia, Salvia, Hortensia , rosemary, sage, St. Johnswort, mint, sweet pepper, tomato and cucumber. 
     The active ingredients according to the invention are especially suitable for controlling  Aphis craccivora, Diabrotica balteata, Heliothis virescens, Myzus persicae, Plutella xylostella  and  Spodoptera littoralis  in cotton, vegetable, maize, rice and soya crops. The active ingredients according to the invention are further especially suitable for controlling  Mamestra  (preferably in vegetables),  Cydia pomonella  (preferably in apples),  Empoasca  (preferably in vegetables, vineyards),  Leptinotarsa  (preferably in potatos) and  Chilo supressalis  (preferably in rice). 
     The compounds of formula (I) are particularly suitable for control of mites, spider mites and rust mites, for example,  Acarapis  spp;  Acarapis woodi; Acarus siro; Acarus  spp;  Aceria sheldoni; Aculops pelekassi; Aculops  spp;  Aculus schlechtendali; Aculus  spp;  Amblyseius fallacis; Brevipalpus  spp;  Brevipalpus phoenicis; Bryobia praetiosa; Bryobia rubrioculus; Caloglyphus  spp;  Cheyletiella blakei; Cheyletiella  spp;  Cheyletiella yasguri; Chorioptes bovis; Chorioptes  spp;  Cytodites  spp;  Demodex bovis; Demodex caballi; Demodex canis; Demodex caprae; Demodex equi; Demodex ovis; Demodex  spp;  Demodex suis; Dermanyssus gallinae; Dermanyssus  spp;  Eotetranychus  spp;  Eotetranychus willamettei; Epitrimerus pyri; Eriophyes ribis; Eriophyes  spp;  Eriophyes vitis; Eutetranychus  spp;  Halotydeus destructor; Hemitarsonemus  spp;  Knemidocoptes  spp;  Laminosioptes  spp;  Listrophorus  spp;  Myobia  spp;  Neoschongastia xerothermobia; Neotrombicula autumnalis; Neotrombicula desaleri; Notoedres cati; Notoedres  spp;  Oligonychus coffeae; Oligonychus ilicis; Oligonychus  spp;  Ornithocheyletia  spp;  Ornithonyssus bursa; Ornithonyssus  spp;  Ornithonyssus sylviarum; Otodectes cynotis; Otodectes  spp;  Panonychus citri; Panonychus  spp;  Panonychus ulmi; Phyllocoptruta oleivora; Phyllocoptruta  spp.;  Phytoseiulus  spp.;  Pneumonyssoides caninum; Polyphagotarsonemus latus; Polyphagotarsonemus  spp;  Psorergates ovis; Psorergates  spp;  Psoroptes cuniculi; Psoroptes equi; Psoroptes ovis; Psoroptes  spp;  Pterolichus  spp;  Raillietia  spp;  Rhizoglyphus  spp;  Sarcoptes bovis; Sarcoptes canis; Sarcoptes caprae; Sarcoptes equi; Sarcoptes ovis; Sarcoptes rupicaprae; Sarcoptes  spp;  Sarcoptes suis; Steneotarsonemus spinki; Steneotarsonemus  spp;  Sternostoma  spp;  Tarsonemus  spp;  Tetranychus cinnabarinus; Tetranychus kanzawai; Tetranychus  spp;  Tetranychus urticae; Trombicula akamushi; Trombicula  spp;  Typhlodromus occidentalis; Tyrophagus  spp;  Varroa jacobsoni; Varroa  spp;  Vasates lycopersici ; and  Zetzellia mali.    
     In an embodiment, a compound of formula (I) are especially suitable for controlling one or more of:  Aceria sheldoni; Aculus lycopersici; Aculus pelekassi; Aculus schlechtendali; Brevipalpus phoenicis; Brevipalpus  spp.;  Bryobia rubrioculus; Eotetranychus carpini; Eotetranychus  spp.;  Epitrimerus pyri; Eriophyes piri; Eriophyes  spp.;  Eriophyes vitis; Eutetranychus africanus; Eutetranychus orientalis; Oligonychus pratensis; Panonychus citri; Panonychus ulmi; Phyllocoptes vitis; Phyllocoptruta oleivora; Polyphagotarsonemus latus; Tetranychus cinnabarinus; Tetranychus kanzawai; Tetranychus  spp.; and  Tetranychus urticae.    
     In a further embodiment, a compound of formula (I) are more especially suitable for controlling one or more of:  Aceria sheldoni; Aculus pelekassi; Brevipalpus phoenicis; Brevipalpus  spp.;  Eriophyes piri; Eriophyes vitis; Eutetranychus africanus; Eutetranychus orientalis; Oligonychus pratensis; Panonychus ulmi; Phyllocoptes vitis; Phyllocoptruta oleivora; Polyphagotarsonemus latus; Tetranychus cinnabarinus; Tetranychus kanzawai; Tetranychus  spp.; and  Tetranychus urticae.    
     The term “crops” is to be understood as including also crop plants which have been so transformed by the use of recombinant DNA techniques that they are capable of synthesising one or more selectively acting toxins, such as are known, for example, from toxin-producing bacteria, especially those of the genus  Bacillus.    
     Toxins that can be expressed by such transgenic plants include, for example, insecticidal proteins, for example insecticidal proteins from  Bacillus cereus  or  Bacillus popilliae ; or insecticidal proteins from  Bacillus thuringiensis , such as δ-endotoxins, e.g. Cry1Ab, Cry1Ac, Cry1F, Cry1 Fa2, Cry2Ab, Cry3A, Cry3Bb1 or Cry9C, or vegetative insecticidal proteins (Vip), e.g. Vip1, Vip2, Vip3 or Vip3A; or insecticidal proteins of bacteria colonising nematodes, for example  Photorhabdus  spp. or  Xenorhabdus  spp., such as  Photorhabdus luminescens, Xenorhabdus nematophilus ; toxins produced by animals, such as scorpion toxins, arachnid toxins, wasp toxins and other insect-specific neurotoxins; toxins produced by fungi, such as Streptomycetes toxins, plant lectins, such as pea lectins, barley lectins or snowdrop lectins; agglutinins; proteinase inhibitors, such as trypsin inhibitors, serine protease inhibitors, patatin, cystatin, papain inhibitors; ribosome-inactivating proteins (RIP), such as ricin, maize-RIP, abrin, luffin, saporin or bryodin; steroid metabolism enzymes, such as 3-hydroxysteroidoxidase, ecdysteroid-UDP-glycosyl-transferase, cholesterol oxidases, ecdysone inhibitors, HMG-COA-reductase, ion channel blockers, such as blockers of sodium or calcium channels, juvenile hormone esterase, diuretic hormone receptors, stilbene synthase, bibenzyl synthase, chitinases and glucanases. 
     In the context of the present invention there are to be understood by δ-endotoxins, for example Cry1Ab, Cry1Ac, Cry1F, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1 or Cry9C, or vegetative insecticidal proteins (Vip), for example Vip1, Vip2, Vip3 or Vip3A, expressly also hybrid toxins, truncated toxins and modified toxins. Hybrid toxins are produced recombinantly by a new combination of different domains of those proteins (see, for example, WO 02/15701). Truncated toxins, for example a truncated Cry1Ab, are known. In the case of modified toxins, one or more amino acids of the naturally occurring toxin are replaced. In such amino acid replacements, preferably non-naturally present protease recognition sequences are inserted into the toxin, such as, for example, in the case of Cry3A055, a cathepsin-G-recognition sequence is inserted into a Cry3A toxin (see WO 03/018810). 
     Examples of such toxins or transgenic plants capable of synthesising such toxins are disclosed, for example, in EP-A-0 374 753, WO 93/07278, WO 95/34656, EP-A-0 427 529, EP-A-451 878 and WO 03/052073. 
     The processes for the preparation of such transgenic plants are generally known to the person skilled in the art and are described, for example, in the publications mentioned above. Cry1-type deoxyribonucleic acids and their preparation are known, for example, from WO 95/34656, EP-A-0 367 474, EP-A-0 401 979 and WO 90/13651. 
     The toxin contained in the transgenic plants imparts to the plants tolerance to harmful insects. Such insects can occur in any taxonomic group of insects, but are especially commonly found in the beetles ( Coleoptera ), two-winged insects ( Diptera ) and moths ( Lepidoptera ). 
     Transgenic plants containing one or more genes that code for an insecticidal resistance and express one or more toxins are known and some of them are commercially available. Examples of such plants are: YieldGard® (maize variety that expresses a Cry1Ab toxin); YieldGard Rootworm® (maize variety that expresses a Cry3Bb1 toxin); YieldGard Plus® (maize variety that expresses a Cry1Ab and a Cry3Bb1 toxin); Starlink® (maize variety that expresses a Cry9C toxin); Herculex I® (maize variety that expresses a Cry1 Fa2 toxin and the enzyme phosphinothricine N-acetyltransferase (PAT) to achieve tolerance to the herbicide glufosinate ammonium); NuCOTN 33B® (cotton variety that expresses a Cry1Ac toxin); Bollgard I® (cotton variety that expresses a Cry1Ac toxin); Bollgard II® (cotton variety that expresses a Cry1Ac and a Cry2Ab toxin); VipCot® (cotton variety that expresses a Vip3A and a Cry1Ab toxin); NewLeaf® (potato variety that expresses a Cry3A toxin); NatureGard®, Agrisure® GT Advantage (GA21 glyphosate-tolerant trait), Agrisure® CB Advantage (Bt11 corn borer (CB) trait) and Protecta®. 
     Further examples of such transgenic crops are: 
     1. Bt11 Maize from Syngenta Seeds SAS, Chemin de I&#39;Hobit 27, F-31 790 St. Sauveur, France, registration number C/FR/96/05/10. Genetically modified  Zea mays  which has been rendered resistant to attack by the European corn borer ( Ostrinia nubilalis  and  Sesamia nonagrioides ) by transgenic expression of a truncated Cry1Ab toxin. Bt11 maize also transgenically expresses the enzyme PAT to achieve tolerance to the herbicide glufosinate ammonium. 
     2. Bt176 Maize from Syngenta Seeds SAS, Chemin de I&#39;Hobit 27, F-31 790 St. Sauveur, France, registration number C/FR/96/05/10. Genetically modified  Zea mays  which has been rendered resistant to attack by the European corn borer ( Ostrinia nubilalis  and  Sesamia nonagrioides ) by transgenic expression of a Cry1Ab toxin. Bt176 maize also transgenically expresses the enzyme PAT to achieve tolerance to the herbicide glufosinate ammonium. 
     3. MIR604 Maize from Syngenta Seeds SAS, Chemin de I&#39;Hobit 27, F-31 790 St. Sauveur, France, registration number C/FR/96/05/10. Maize which has been rendered insect-resistant by transgenic expression of a modified Cry3A toxin. This toxin is Cry3A055 modified by insertion of a cathepsin-G-protease recognition sequence. The preparation of such transgenic maize plants is described in WO 03/018810. 
     4. MON 863 Maize from Monsanto Europe S.A. 270-272 Avenue de Tervuren, B-1150 Brussels, Belgium, registration number C/DE/02/9. MON 863 expresses a Cry3Bb1 toxin and has resistance to certain  Coleoptera  insects. 
     5. IPC 531 Cotton from Monsanto Europe S.A. 270-272 Avenue de Tervuren, B-1150 Brussels, Belgium, registration number C/ES/96/02. 
     6. 1507 Maize from Pioneer Overseas Corporation, Avenue Tedesco, 7 B-1160 Brussels, Belgium, registration number C/NL/00/10. Genetically modified maize for the expression of the protein Cry1F for achieving resistance to certain  Lepidoptera  insects and of the PAT protein for achieving tolerance to the herbicide glufosinate ammonium. 
     7. NK603×MON 810 Maize from Monsanto Europe S.A. 270-272 Avenue de Tervuren, B-1150 Brussels, Belgium, registration number C/GB/02/M3/03. Consists of conventionally bred hybrid maize varieties by crossing the genetically modified varieties NK603 and MON 810. NK603×MON 810 Maize transgenically expresses the protein CP4 EPSPS, obtained from  Agrobacterium  sp. strain CP4, which imparts tolerance to the herbicide Roundup® (contains glyphosate) and also a Cry1Ab toxin obtained from  Bacillus thuringiensis  subsp.  kurstaki  which brings about tolerance to certain  Lepidoptera , include the European corn borer. 
     Transgenic crops of insect-resistant plants are also described in BATS (Zentrum für Biosicherheit und Nachhaltigkeit, Zentrum BATS, Clarastrasse 13, 4058 Basel, Switzerland) Report 2003, (http://bats.ch). 
     The term “crops” is to be understood as including also crop plants which have been so transformed by the use of recombinant DNA techniques that they are capable of synthesising antipathogenic substances having a selective action, such as, for example, the so-called “pathogenesis-related proteins” (PRPs, see e.g. EP-A-0 392 225). Examples of such antipathogenic substances and transgenic plants capable of synthesising such antipathogenic substances are known, for example, from EP-A-0 392 225, WO 95/33818 and EP-A-0 353 191. The methods of producing such transgenic plants are generally known to the person skilled in the art and are described, for example, in the publications mentioned above. 
     Crops may also be modified for enhanced resistance to fungal (for example  Fusarium, Anthracnose , or  Phytophthora ), bacterial (for example  Pseudomonas ) or viral (for example potato leafroll virus, tomato spotted wilt virus, cucumber mosaic virus) pathogens. 
     Crops also include those that have enhanced resistance to nematodes, such as the soybean cyst nematode. 
     Crops that are tolerance to abiotic stress include those that have enhanced tolerance to drought, high salt, high temperature, chill, frost, or light radiation, for example through expression of NF-YB or other proteins known in the art. 
     Antipathogenic substances which can be expressed by such transgenic plants include, for example, ion channel blockers, such as blockers for sodium and calcium channels, for example the viral KP1, KP4 or KP6 toxins; stilbene synthases; bibenzyl synthases; chitinases; glucanases; the so-called “pathogenesis-related proteins” (PRPs; see e.g. EP-A-0 392 225); antipathogenic substances produced by microorganisms, for example peptide antibiotics or heterocyclic antibiotics (see e.g. WO 95/33818) or protein or polypeptide factors involved in plant pathogen defence (so-called “plant disease resistance genes”, as described in WO 03/000906). 
     Further areas of use of the compositions according to the invention are the protection of stored goods and store rooms and the protection of raw materials, such as wood, textiles, floor coverings or buildings and also in the hygiene sector, especially the protection of humans, domestic animals and productive livestock against pests of the mentioned type. 
     The present invention provides a compound of the first aspect for use in therapy. The present invention provides a compound of the first aspect, for use in controlling parasites in or on an animal. The present invention further provides a compound of the first aspect, for use in controlling ectoparasites on an animal. The present invention further provides a compound of the first aspect, for use in preventing and/or treating diseases transmitted by ectoparasites. 
     The present invention provides the use of a compound of the first aspect, for the manufacture of a medicament for controlling parasites in or on an animal. The present invention further provides the use of a compound of the first aspect, for the manufacture of a medicament for controlling ectoparasites on an animal. The present invention further provides the use of a compound of the first aspect, for the manufacture of a medicament for preventing and/or treating diseases transmitted by ectoparasites. 
     The present invention provides the use of a compound of the first aspect, in controlling parasites in or on an animal. The present invention further provides the use of a compound of the first aspect, in controlling ectoparasites on an animal. 
     The term “controlling” when used in context of parasites in or on an animal refers to reducing the number of pests or parasites, eliminating pests or parasites and/or preventing further pest or parasite infestation. 
     The term “treating” when used used in context of parasites in or on an animal refers to restraining, slowing, stopping or reversing the progression or severity of an existing symptom or disease. The term “preventing” when used used in context of parasites in or on an animal refers to the avoidance of a symptom or disease developing in the animal. 
     The term “animal” when used used in context of parasites in or on an animal may refer to a mammal and a non-mammal, such as a bird or fish. In the case of a mammal, it may be a human or non-human mammal. Non-human mammals include, but are not limited to, livestock animals and companion animals. Livestock animals include, but are not limited to, cattle, camellids, pigs, sheep, goats and horses. Companion animals include, but are not limited to, dogs, cats and rabbits. 
     A “parasite” is a pest which lives in or on the host animal and benefits by deriving nutrients at the host animal&#39;s expense. An “endoparasite” is a parasite which lives in the host animal. An “ectoparasite” is a parasite which lives on the host animal. Ectoparasites include, but are not limited to,  acari , insects and crustaceans (e.g. sea lice). The  Acari  (or  Acarina ) sub-class comprises ticks and mites. Ticks include, but are not limited to, members of the following genera:  Rhipicaphalus , for example,  Rhipicaphalus  ( Boophilus )  microplus  and  Rhipicephalus sanguineus; Amblyomrna; Dermacentor; Haemaphysalis; Hyalomma; Ixodes; Rhipicentor; Margaropus; Argas; Otobius ; and  Ornithodoros . Mites include, but are not limited to, members of the following genera:  Chorioptes , for example  Chorioptes bovis; Psoroptes , for example  Psoroptes ovis; Cheyletiella; Dermanyssus ; for example  Dermanyssus gallinae; Ortnithonyssus; Demodex , for example  Demodex canis; Sarcoptes , for example  Sarcoptes scabiei ; and  Psorergates . Insects include, but are not limited to, members of the orders:  Siphonaptera, Diptera, Phthiraptera, Lepidoptera, Coleoptera  and  Homoptera . Members of the  Siphonaptera  order include, but are not limited to,  Ctenocephalides felis  and  Ctenocephatides canis . Members of the  Diptera  order include, but are not limited to,  Musca  spp.; bot fly, for example  Gasterophilus intestinalis  and  Oestrus ovis ; biting flies; horse flies, for example  Haematopota  spp. and  Tabunus  spp.;  haematobia , for example  haematobia irritans; Stomoxys; Lucilia ; midges; and mosquitoes. Members of the  Phthiraptera  class include, but are not limited to, blood sucking lice and chewing lice, for example  Bovicola Ovis  and  Bovicola Bovis.    
     The term “effective amount” when used used in context of parasites in or on an animal refers to the amount or dose of the compound of the invention, or a salt thereof, which, upon single or multiple dose administration to the animal, provides the desired effect in or on the animal. The effective amount can be readily determined by the attending diagnostician, as one skilled in the art, by the use of known techniques and by observing results obtained under analogous circumstances. In determining the effective amount a number of factors are considered by the attending diagnostician, including, but not limited to: the species of mammal; its size, age and general health; the parasite to be controlled and the degree of infestation; the specific disease or disorder involved; the degree of or involvement or the severity of the disease or disorder; the response of the individual; the particular compound administered; the mode of administration; the bioavailability characteristics of the preparation administered; the dose regimen selected; the use of concomitant medication; and other relevant circumstances. 
     The compounds of the invention may be administered to the animal by any route which has the desired effect including, but not limited to topically, orally, parenterally and subcutaneously. Topical administration is preferred. Formulations suitable for topical administration include, for example, solutions, emulsions and suspensions and may take the form of a pour-on, spot-on, spray-on, spray race or dip. In the alternative, the compounds of the invention may be administered by means of an ear tag or collar. 
     Salt forms of the compounds of the invention include both pharmaceutically acceptable salts and veterinary acceptable salts, which can be different to agrochemically acceptable salts. Pharmaceutically and veterinary acceptable salts and common methodology for preparing them are well known in the art. See, for example, Gould, P. L., “Salt selection for basic drugs”, International Journal of Pharmaceutics, 33: 201-217 (1986); Bastin, R. J., et al. “Salt Selection and Optimization Procedures for Pharmaceutical New Chemical Entities”, Organic Process Research and Development, 4: 427-435 (2000); and Berge, S. M., et al., “Pharmaceutical Salts”, Journal of Pharmaceutical Sciences, 66: 1-19, (1977). One skilled in the art of synthesis will appreciate that the compounds of the invention are readily converted to and may be isolated as a salt, such as a hydrochloride salt, using techniques and conditions well known to one of ordinary skill in the art. In addition, one skilled in the art of synthesis will appreciate that the compounds of the invention are readily converted to and may be isolated as the corresponding free base from the corresponding salt. 
     The present invention also provides a method for controlling pests (such as mosquitoes and other disease vectors; see also http://www.who.int/malaria/vector_control/irs/en/). In one embodiment, the method for controlling pests comprises applying the compositions of the invention to the target pests, to their locus or to a surface or substrate by brushing, rolling, spraying, spreading or dipping. By way of example, an IRS (indoor residual spraying) application of a surface such as a wall, ceiling or floor surface is contemplated by the method of the invention. In another embodiment, it is contemplated to apply such compositions to a substrate such as non-woven or a fabric material in the form of (or which can be used in the manufacture of) netting, clothing, bedding, curtains and tents. 
     In one embodiment, the method for controlling such pests comprises applying a pesticidally effective amount of the compositions of the invention to the target pests, to their locus, or to a surface or substrate so as to provide effective residual pesticidal activity on the surface or substrate. Such application may be made by brushing, rolling, spraying, spreading or dipping the pesticidal composition of the invention. By way of example, an IRS application of a surface such as a wall, ceiling or floor surface is contemplated by the method of the invention so as to provide effective residual pesticidal activity on the surface. In another embodiment, it is contemplated to apply such compositions for residual control of pests on a substrate such as a fabric material in the form of (or which can be used in the manufacture of) netting, clothing, bedding, curtains and tents. 
     Substrates including non-woven, fabrics or netting to be treated may be made of natural fibres such as cotton, raffia, jute, flax, sisal, hessian, or wool, or synthetic fibres such as polyamide, polyester, polypropylene, polyacrylonitrile or the like. The polyesters are particularly suitable. The methods of textile treatment are known, e.g. WO 2008/151984, WO 2003/034823, U.S. Pat. No. 5,631,072, WO 2005/64072, WO2006/128870, EP 1724392, WO 2005113886 or WO 2007/090739. 
     Further areas of use of the compositions according to the invention are the field of tree injection/trunk treatment for all ornamental trees as well all sort of fruit and nut trees. 
     In the field of tree injection/trunk treatment, the compounds according to the present invention are especially suitable against wood-boring insects from the order  Lepidoptera  as mentioned above and from the order  Coleoptera , especially against woodborers listed in the following tables A and B: 
     
       
         
           
               
             
               
                 TABLE A 
               
             
            
               
                   
               
               
                 Examples of exotic woodborers of economic importance. 
               
            
           
           
               
               
               
            
               
                 Family 
                 Species 
                 Host or Crop Infested 
               
               
                   
               
               
                 Buprestidae 
                 
                   Agrilus planipennis 
                 
                 Ash 
               
               
                 Cerambycidae 
                 
                   Anoplura glabripennis 
                 
                 Hardwoods 
               
               
                 Scolytidae 
                 
                   Xylosandrus crassiusculus 
                 
                 Hardwoods 
               
               
                   
                 
                   X. mutilatus 
                 
                 Hardwoods 
               
               
                   
                 
                   Tomicus piniperda 
                 
                 Conifers 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE B 
               
             
            
               
                   
               
               
                 Examples of native woodborers of economic importance. 
               
            
           
           
               
               
               
            
               
                 Family 
                 Species 
                 Host or Crop Infested 
               
               
                   
               
               
                 Buprestidae 
                 
                   Agrilus anxius 
                 
                 Birch 
               
               
                   
                 
                   Agrilus politus 
                 
                 Willow, Maple 
               
               
                   
                 
                   Agrilus sayi 
                 
                 Bayberry, Sweetfern 
               
               
                   
                 
                   Agrilus vittaticolllis 
                 
                 Apple, Pear, Cranberry, 
               
               
                   
                   
                 Serviceberry, Hawthorn 
               
               
                   
                 
                   Chrysobothris  
                 
                 Apple, Apricot, Beech, Boxelder, 
               
               
                   
                 
                   femorata 
                 
                 Cherry, Chestnut, Currant, Elm, 
               
               
                   
                   
                 Hawthorn, Hackberry, Hickory, 
               
               
                   
                   
                 Horsechestnut, Linden, Maple, 
               
               
                   
                   
                 Mountain-ash, Oak, Pecan, Pear, 
               
               
                   
                   
                 Peach, Persimmon, Plum, Poplar, 
               
               
                   
                   
                 Quince, Redbud, Serviceberry, 
               
               
                   
                   
                 Sycamore, Walnut, Willow 
               
               
                   
                 
                   Texania campestris 
                 
                 Basswood, Beech, Maple, Oak, 
               
               
                   
                   
                 Sycamore, Willow, Yellow- 
               
               
                   
                   
                 poplar 
               
               
                 Cerambycidae 
                 
                   Goes pulverulentus 
                 
                 Beech, Elm, Nuttall, Willow,  
               
               
                   
                   
                 Black oak, Cherrybark oak,  
               
               
                   
                   
                 Water oak, Sycamore 
               
               
                   
                 
                   Goes tigrinus 
                 
                 Oak 
               
               
                   
                 
                   Neoclytus acuminatus 
                 
                 Ash, Hickory, Oak, Walnut,  
               
               
                   
                   
                 Birch, Beech, Maple, Eastern 
               
               
                   
                   
                 hophornbeam, Dogwood, 
               
               
                   
                   
                 Persimmon, Redbud, Holly, 
               
               
                   
                   
                 Hackberry, Black locust, 
               
               
                   
                   
                 Honeylocust, Yellow-poplar, 
               
               
                   
                   
                 Chestnut, Osage-orange,  
               
               
                   
                   
                 Sassafras, Lilac, Mountain- 
               
               
                   
                   
                 mahogany, Pear, Cherry,  
               
               
                   
                   
                 Plum, Peach, Apple, Elm, 
               
               
                   
                   
                 Basswood, Sweetgum 
               
               
                   
                 
                   Neoptychodes  
                 
                 Fig, Alder, Mulberry, Willow,  
               
               
                   
                 
                   trilineatus 
                 
                 Netleaf hackberry 
               
               
                   
                 
                   Oberea ocellata 
                 
                 Sumac, Apple, Peach, Plum,  
               
               
                   
                   
                 Pear, Currant, Blackberry 
               
               
                   
                 
                   Oberea tripunctata 
                 
                 Dogwood, Viburnum, Elm, 
               
               
                   
                   
                 Sourwood, Blueberry, 
               
               
                   
                   
                 Rhododendron, Azalea, Laurel, 
               
               
                   
                   
                 Poplar, Willow, Mulberry 
               
               
                   
                 
                   Oncideres cingulata 
                 
                 Hickory, Pecan, Persimmon,  
               
               
                   
                   
                 Elm, Sourwood, Basswood,  
               
               
                   
                   
                 Honeylocust, Dogwood,  
               
               
                   
                   
                 Eucalyptus, Oak, 
               
               
                   
                   
                 Hackberry, Maple, Fruit trees 
               
               
                   
                 
                   Saperda calcarata 
                 
                 Poplar 
               
               
                   
                 
                   Strophiona nitens 
                 
                 Chestnut, Oak, Hickory, Walnut, 
               
               
                   
                   
                 Beech, Maple 
               
               
                 Scolytidae 
                 
                   Corthylus  
                 
                 Maple, Oak, Yellow-poplar,  
               
               
                   
                 
                   columbianus 
                 
                 Beech, Boxelder, Sycamore,  
               
               
                   
                   
                 Birch, Basswood, Chestnut, Elm 
               
               
                   
                 
                   Dendroctonus  
                 
                 Pine 
               
               
                   
                 
                   frontalis 
                 
                   
               
               
                   
                 
                   Dryocoetes betulae 
                 
                 Birch, Sweetgum, Wild cherry, 
               
               
                   
                   
                 Beech, Pear 
               
               
                   
                 
                   Monarthrum  
                 
                 Oak, Maple, Birch, Chestnut, 
               
               
                   
                 
                   fasciatum 
                 
                 Sweetgum, Blackgum, Poplar, 
               
               
                   
                   
                 Hickory, Mimosa, Apple,  
               
               
                   
                   
                 Peach, Pine 
               
               
                   
                 
                   Phloeotribus  
                 
                 Peach, Cherry, Plum, Black  
               
               
                   
                 
                   liminaris 
                 
                 cherry, Elm, Mulberry,  
               
               
                   
                   
                 Mountain-ash 
               
               
                   
                 
                   Pseudopityophthorus  
                 
                 Oak, American beech, Black  
               
               
                   
                 
                   pruinosus 
                 
                 cherry, Chickasaw plum,  
               
               
                   
                   
                 Chestnut, Maple, Hickory,  
               
               
                   
                   
                 Hornbeam, Hophornbeam 
               
               
                 Sesiidae 
                 
                   Paranthrene simulans 
                 
                 Oak, American chestnut 
               
               
                   
                 
                   Sannina uroceriformis 
                 
                 Persimmon 
               
               
                   
                 
                   Synanthedon exitiosa 
                 
                 Peach, Plum, Nectarine, Cherry, 
               
               
                   
                   
                 Apricot, Almond, Black cherry 
               
               
                   
                 
                   Synanthedon pictipes 
                 
                 Peach, Plum, Cherry, Beach,  
               
               
                   
                   
                 Black Cherry 
               
               
                   
                 
                   Synanthedon  
                 
                 Tupelo 
               
               
                   
                 
                   rubrofascia 
                 
                   
               
               
                   
                 
                   Synanthedon scitula 
                 
                 Dogwood, Pecan, Hickory, Oak, 
               
               
                   
                   
                 Chestnut, Beech, Birch, Black  
               
               
                   
                   
                 cherry, Elm, Mountain-ash,  
               
               
                   
                   
                 Viburnum, Willow, Apple,  
               
               
                   
                   
                 Loquat, Ninebark, Bayberry 
               
               
                   
                 
                   Vitacea polistiformis 
                 
                 Grape 
               
               
                   
               
            
           
         
       
     
     The present invention may be also used to control any insect pests that may be present in turfgrass, including for example beetles, caterpillars, fire ants, ground pearls, millipedes, sow bugs, mites, mole crickets, scales, mealybugs, ticks, spittlebugs, southern chinch bugs and white grubs. The present invention may be used to control insect pests at various stages of their life cycle, including eggs, larvae, nymphs and adults. 
     In particular, the present invention may be used to control insect pests that feed on the roots of turfgrass including white grubs (such as  Cyclocephala  spp. (e.g. masked chafer,  C. lurida ),  Rhizotrogus  spp. (e.g. European chafer,  R. majalis ),  Cotinus  spp. (e.g. Green June beetle,  C. nitida ),  Popillia  spp. (e.g. Japanese beetle,  P. japonica ),  Phyllophaga  spp. (e.g. May/June beetle),  Ataenius  spp. (e.g. Black turfgrass  ataenius, A. spretulus ),  Maladera  spp. (e.g. Asiatic garden beetle,  M. castanea ) and  Tomarus  spp.), ground pearls ( Margarodes  spp.), mole crickets (tawny, southern and short-winged;  Scapteriscus  spp.,  Gryllotalpa africana ) and leatherjackets (European crane fly,  Tipula  spp.). 
     The present invention may also be used to control insect pests of turfgrass that are thatch dwelling, including armyworms (such as fall armyworm  Spodoptera frugiperda  and common armyworm  Pseudaletia unipuncta ), cutworms, billbugs ( Sphenophorus  spp., such as  S. venatus verstitus  and  S. parvulus ) and sod webworms (such as  Crambus  spp. and the tropical sod webworm,  Herpetogramma phaeopteralis ). 
     The present invention may also be used to control insect pests of turfgrass that live above the ground and feed on the turfgrass leaves, including chinch bugs (such as southern chinch bugs,  Blissus insularis ), Bermudagrass mite ( Eriophyes cynodoniensis ), rhodesgrass mealybug ( Antonina graminis ), two-lined spittlebug ( Propsapia bicincta ), leafhoppers, cutworms (Noctuidae family), and greenbugs. 
     The present invention may also be used to control other pests of turfgrass such as red imported fire ants ( Solenopsis invicta ) that create ant mounds in turf. 
     In the hygiene sector, the compositions according to the invention are active against ectoparasites such as hard ticks, soft ticks, mange mites, harvest mites, flies (biting and licking), parasitic fly larvae, lice, hair lice, bird lice and fleas. 
     Examples of such parasites are: 
     Of the order  Anoplurida: Haematopinus  spp.,  Linognathus  spp.,  Pediculus  spp. and  Phtirus  spp.,  Solenopotes  spp. 
     Of the order  Mallophagida: Trimenopon  spp.,  Menopon  spp.,  Trinoton  spp.,  Bovicola  spp.,  Werneckiella  spp.,  Lepikentron  spp.,  Damalina  spp.,  Trichodectes  spp. and  Felicola  spp. 
     Of the order  Diptera  and the suborders Nematocerina and Brachycerina, for example  Aedes  spp.,  Anopheles  spp.,  Culex  spp.,  Simulium  spp.,  Eusimulium  spp.,  Phlebotomus  spp.,  Lutzomyia  spp.,  Culicoides  spp.,  Chrysops  spp.,  Hybomitra  spp.,  Atylotus  spp.,  Tabanus  spp.,  Haematopota  spp.,  Philipomyia  spp.,  Braula  spp.,  Musca  spp.,  Hydrotaea  spp.,  Stomoxys  spp.,  Haematobia  spp.,  Morellia  spp.,  Fannia  spp.,  Glossina  spp.,  Calliphora  spp.,  Lucilia  spp.,  Chrysomyia  spp.,  Wohlfahrtia  spp.,  Sarcophaga  spp.,  Oestrus  spp.,  Hypoderma  spp.,  Gasterophilus  spp.,  Hippobosca  spp.,  Lipoptena  spp. and  Melophagus  spp. 
     Of the order  Siphonapterida , for example  Pulex  spp.,  Ctenocephalides  spp.,  Xenopsylla  spp.,  Ceratophyllus  spp. 
     Of the order  Heteropterida , for example  Cimex  spp.,  Triatoma  spp.,  Rhodnius  spp.,  Panstrongylus  spp. 
     Of the order  Blattarida , for example  Blatta orientalis, Periplaneta americana, Blattelagermanica  and  Supella  spp. 
     Of the subclass Acaria (Acarida) and the orders Meta- and Meso- stigmata , for example  Argas  spp.,  Ornithodorus  spp.,  Otobius  spp.,  Ixodes  spp.,  Amblyomma  spp.,  Boophilus  spp.,  Dermacentor  spp.,  Haemophysalis  spp.,  Hyalomma  spp.,  Rhipicephalus  spp.,  Dermanyssus  spp.,  Raillietia  spp.,  Pneumonyssus  spp.,  Sternostoma  spp. and  Varroa  spp. 
     Of the orders  Actinedida  ( Prostigmata ) and  Acaridida  ( Astigmata ), for example  Acarapis  spp.,  Cheyletiella  spp.,  Ornithocheyletia  spp.,  Myobia  spp.,  Psorergates  spp.,  Demodex  spp.,  Trombicula  spp.,  Listrophorus  spp.,  Acarus  spp.,  Tyrophagus  spp.,  Caloglyphus  spp.,  Hypodectes  spp.,  Pterolichus  spp.,  Psoroptes  spp.,  Chorioptes  spp.,  Otodectes  spp.,  Sarcoptes  spp.,  Notoedres  spp.,  Knemidocoptes  spp.,  Cytodites  spp. and  Laminosioptes  spp. 
     The compositions according to the invention are also suitable for protecting against insect infestation in the case of materials such as wood, textiles, plastics, adhesives, glues, paints, paper and card, leather, floor coverings and buildings. 
     The compositions according to the invention can be used, for example, against the following pests: beetles such as  Hylotrupes bajulus, Chlorophorus pilosis, Anobium punctatum, Xestobium rufovillosum, Ptilinuspecticornis, Dendrobium pertinex, Ernobius mollis, Priobium carpini, Lyctus brunneus, Lyctus africanus, Lyctus planicollis, Lyctus linearis, Lyctus pubescens, Trogoxylon aequale, Minthesrugicollis, Xyleborus  spec.,  Tryptodendron  spec.,  Apate monachus, Bostrychus capucins, Heterobostrychus brunneus, Sinoxylon  spec. and  Dinoderus minutus  and also hymenopterans such as  Sirexjuvencus, Urocerus gigas, Urocerus gigas taignus and Urocerus augur ; termites such as  Kalotermes flavicollis, Cryptotermes brevis, Heterotermes indicola, Reticulitermes flavipes, Reticulitermes santonensis, Reticulitermes lucifugus, Mastotermes darwiniensis, Zootermopsis nevadensis  and  Coptotermes formosanus ; and bristletails such as  Lepisma saccharina . The compounds of formulae I and I′a, or salts thereof, are especially suitable for controlling one or more pests selected from the family: Noctuidae, Plutellidae, Chrysomelidae, Thripidae, Pentatomidae, Tortricidae, Delphacidae, Aphididae, Noctuidae, Crambidae, Meloidogynidae and Heteroderidae. In a preferred embodiment of each aspect, a compound TX (where the abbreviation “TX” means “one compound selected from the compounds defined in Tables 1 to 35 and Tables P1 to P8) controls one or more of pests selected from the family: Noctuidae, Plutellidae, Chrysomelidae, Thripidae, Pentatomidae, Tortricidae, Delphacidae, Aphididae, Noctuidae, Crambidae, Meloidogynidae and Heteroderidae. 
     The compounds of formulae I and I′a, or salts thereof, are especially suitable for controlling one or more of pests selected from the genus:  Spodoptera  spp,  Plutella  spp,  Frankliniella  spp,  Thrips  spp,  Euschistus  spp,  Cydia  spp,  Nilaparvata  spp,  Myzus  spp,  Aphis  spp,  Diabrotica  spp,  Rhopalosiphum  spp,  Pseudoplusia  spp and  Chilo  spp. In a preferred embodiment of each aspect, a compound TX (where the abbreviation “TX” means “one compound selected from the compounds defined in Tables 1 to 35 and Tables P1 to P8) controls one or more of pests selected from the genus:  Spodoptera  spp,  Plutella  spp,  Frankliniella  spp,  Thrips  spp,  Euschistus  spp,  Cydia  spp,  Nilaparvata  spp,  Myzus  spp,  Aphis  spp,  Diabrotica  spp,  Rhopalosiphum  spp,  Pseudoplusia  spp and  Chilo  spp. 
     The compounds of formulae I and I′a, or salts thereof, are especially suitable for controlling one or more of  Spodoptera littoralis, Plutella xylostella, Frankliniella occidentalis, Thrips tabaci, Euschistus heros, Cydia pomonella, Nilaparvata lugens, Myzus persicae, Chrysodeixis includens, Aphis craccivora, Diabrotica balteata, Rhopalosiphum padi  and  Chilo suppressalis.    
     In a preferred embodiment of each aspect, a compound TX (where the abbreviation “TX” means “one compound selected from the compounds defined in Tables 1 to 35 and Tables P1 to P8) controls one or more of  Spodoptera littoralis, Plutella xylostella, Frankliniella occidentalis, Thrips tabaci, Euschistus heros, Cydia pomonella, Nilaparvata lugens, Myzus persicae, Chrysodeixis includens, Aphis craccivora, Diabrotica balteata, Rhopalosiphum Padia  and  Chilo Suppressalis , such as  Spodoptera littoralis +TX,  Plutella xylostella +TX;  Frankliniella occidentalis +TX,  Thrips tabaci +TX,  Euschistus heros +TX,  Cydia pomonella +TX,  Nilaparvata lugens +TX,  Myzus persicae +TX,  Chrysodeixis includens +TX,  Aphis craccivora +TX,  Diabrotica balteata +TX,  Rhopalosiphum Padi +TX and  Chilo suppressalis +TX. 
     In an embodiment, of each aspect, one compound from Tables 1 to 35 and Tables P1 to P8 is suitable for controlling  Spodoptera littoralis, Plutella xylostella, Frankliniella occidentalis, Thrips tabaci, Euschistus heros, Cydia pomonella, Nilaparvata lugens, Myzus persicae, Chrysodeixis includens, Aphis craccivora, Diabrotica balteata, Rhopalosiphum Padia  and  Chilo Suppressalis  in cotton, vegetable, maize, cereal, rice and soya crops. 
     In an embodiment, one compound from Tables 1 to 35 and Table P1 to P8 is suitable for controlling  Mamestra  (preferably in vegetables),  Cydia pomonella  (preferably in apples),  Empoasca  (preferably in vegetables, vineyards),  Leptinotarsa  (preferably in potatos) and  Chilo supressalis  (preferably in rice). 
     Compounds according to the invention may possess any number of benefits including, inter alia, advantageous levels of biological activity for protecting plants against insects or superior properties for use as agrochemical active ingredients (for example, greater biological activity, an advantageous spectrum of activity, an increased safety profile (against non-target organisms above and below ground (such as fish, birds and bees), improved physico-chemical properties, or increased biodegradability). In particular, it has been surprisingly found that certain compounds of formula (I) may show an advantageous safety profile with respect to non-target arthropods, in particular pollinators such as honey bees, solitary bees and bumble bees. Most particularly,  Apis mellifera.    
     The compounds according to the invention can be used as pesticidal agents in unmodified form, but they are generally formulated into compositions in various ways using formulation adjuvants, such as carriers, solvents and surface-active substances. The formulations can be in various physical forms, e.g. in the form of dusting powders, gels, wettable powders, water-dispersible granules, water-dispersible tablets, effervescent pellets, emulsifiable concentrates, microemulsifiable concentrates, oil-in-water emulsions, oil-flowables, aqueous dispersions, oily dispersions, suspo-emulsions, capsule suspensions, emulsifiable granules, soluble liquids, water-soluble concentrates (with water or a water-miscible organic solvent as carrier), impregnated polymer films or in other forms known e.g. from the Manual on Development and Use of FAO and WHO Specifications for Pesticides, United Nations, First Edition, Second Revision (2010). Such formulations can either be used directly or diluted prior to use. The dilutions can be made, for example, with water, liquid fertilisers, micronutrients, biological organisms, oil or solvents. 
     The formulations can be prepared e.g. by mixing the active ingredient with the formulation adjuvants in order to obtain compositions in the form of finely divided solids, granules, solutions, dispersions or emulsions. The active ingredients can also be formulated with other adjuvants, such as finely divided solids, mineral oils, oils of vegetable or animal origin, modified oils of vegetable or animal origin, organic solvents, water, surface-active substances or combinations thereof. 
     The active ingredients can also be contained in very fine microcapsules. Microcapsules contain the active ingredients in a porous carrier. This enables the active ingredients to be released into the environment in controlled amounts (e.g. slow-release). Microcapsules usually have a diameter of from 0.1 to 500 microns. They contain active ingredients in an amount of about from 25 to 95% by weight of the capsule weight. The active ingredients can be in the form of a monolithic solid, in the form of fine particles in solid or liquid dispersion or in the form of a suitable solution. The encapsulating membranes can comprise, for example, natural or synthetic rubbers, cellulose, styrene/butadiene copolymers, polyacrylonitrile, polyacrylate, polyesters, polyamides, polyureas, polyurethane or chemically modified polymers and starch xanthates or other polymers that are known to the person skilled in the art. Alternatively, very fine microcapsules can be formed in which the active ingredient is contained in the form of finely divided particles in a solid matrix of base substance, but the microcapsules are not themselves encapsulated. 
     The formulation adjuvants that are suitable for the preparation of the compositions according to the invention are known per se. As liquid carriers there may be used: water, toluene, xylene, petroleum ether, vegetable oils, acetone, methyl ethyl ketone, cyclohexanone, acid anhydrides, acetonitrile, acetophenone, amyl acetate, 2-butanone, butylene carbonate, chlorobenzene, cyclohexane, cyclohexanol, alkyl esters of acetic acid, diacetone alcohol, 1,2-dichloropropane, diethanolamine, p-diethylbenzene, diethylene glycol, diethylene glycol abietate, diethylene glycol butyl ether, diethylene glycol ethyl ether, diethylene glycol methyl ether, N,N-dimethylformamide, dimethyl sulfoxide, 1,4-dioxane, dipropylene glycol, dipropylene glycol methyl ether, dipropylene glycol dibenzoate, diproxitol, alkylpyrrolidone, ethyl acetate, 2-ethylhexanol, ethylene carbonate, 1,1,1-trichloroethane, 2-heptanone, alpha-pinene, d-limonene, ethyl lactate, ethylene glycol, ethylene glycol butyl ether, ethylene glycol methyl ether, gamma-butyrolactone, glycerol, glycerol acetate, glycerol diacetate, glycerol triacetate, hexadecane, hexylene glycol, isoamyl acetate, isobornyl acetate, isooctane, isophorone, isopropylbenzene, isopropyl myristate, lactic acid, laurylamine, mesityl oxide, methoxy-propanol, methyl isoamyl ketone, methyl isobutyl ketone, methyl laurate, methyl  octanoate , methyl oleate, methylene chloride, m-xylene, n-hexane, n-octylamine, octadecanoic acid, octylamine acetate, oleic acid, oleylamine, o-xylene, phenol, polyethylene glycol, propionic acid, propyl lactate, propylene carbonate, propylene glycol, propylene glycol methyl ether, p-xylene, toluene, triethyl phosphate, triethylene glycol, xylenesulfonic acid, paraffin, mineral oil, trichloroethylene, perchloroethylene, ethyl acetate, amyl acetate, butyl acetate, propylene glycol methyl ether, diethylene glycol methyl ether, methanol, ethanol, isopropanol and alcohols of higher molecular weight, such as amyl alcohol, tetrahydrofurfuryl alcohol, hexanol, octanol, ethylene glycol, propylene glycol, glycerol, N-methyl-2-pyrrolidone and the like. 
     Suitable solid carriers are, for example, talc, titanium dioxide, pyrophyllite clay, silica, attapulgite clay, kieselguhr, limestone, calcium carbonate, bentonite, calcium montmorillonite, cottonseed husks, wheat flour, soybean flour, pumice, wood flour, ground walnut shells, lignin and similar substances. 
     A large number of surface-active substances can advantageously be used in both solid and liquid formulations, especially in those formulations which can be diluted with a carrier prior to use. Surface-active substances may be anionic, cationic, non-ionic or polymeric and they can be used as emulsifiers, wetting agents or suspending agents or for other purposes. Typical surface-active substances include, for example, salts of alkyl sulfates, such as diethanolammonium lauryl sulfate; salts of alkylarylsulfonates, such as calcium dodecylbenzenesulfonate; alkylphenol/alkylene oxide addition products, such as nonylphenol ethoxylate; alcohol/alkylene oxide addition products, such as tridecylalcohol ethoxylate; soaps, such as sodium stearate; salts of alkylnaphthalenesulfonates, such as sodium dibutylnaphthalenesulfonate; dialkyl esters of sulfosuccinate salts, such as sodium di(2-ethylhexyl)sulfosuccinate; sorbitol esters, such as sorbitol oleate; quaternary amines, such as lauryltrimethylammonium chloride, polyethylene glycol esters of fatty acids, such as polyethylene glycol stearate; block copolymers of ethylene oxide and propylene oxide; and salts of mono- and di-alkylphosphate esters; and also further substances described e.g. in McCutcheon&#39;s Detergents and Emulsifiers Annual, MC Publishing Corp., Ridgewood N.J. (1981). 
     Further adjuvants that can be used in pesticidal formulations include crystallisation inhibitors, viscosity modifiers, suspending agents, dyes, anti-oxidants, foaming agents, light absorbers, mixing auxiliaries, antifoams, complexing agents, neutralising or pH-modifying substances and buffers, corrosion inhibitors, fragrances, wetting agents, take-up enhancers, micronutrients, plasticisers, glidants, lubricants, dispersants, thickeners, antifreezes, microbicides, and liquid and solid fertilisers. 
     The compositions according to the invention can include an additive comprising an oil of vegetable or animal origin, a mineral oil, alkyl esters of such oils or mixtures of such oils and oil derivatives. The amount of oil additive in the composition according to the invention is generally from 0.01 to 10%, based on the mixture to be applied. For example, the oil additive can be added to a spray tank in the desired concentration after a spray mixture has been prepared. Preferred oil additives comprise mineral oils or an oil of vegetable origin, for example rapeseed oil, olive oil or sunflower oil, emulsified vegetable oil, alkyl esters of oils of vegetable origin, for example the methyl derivatives, or an oil of animal origin, such as fish oil or beef tallow. Preferred oil additives comprise alkyl esters of C 8 -C 22  fatty acids, especially the methyl derivatives of C 12 -C 18  fatty acids, for example the methyl esters of lauric acid, palmitic acid and oleic acid (methyl laurate, methyl palmitate and methyl oleate, respectively). Many oil derivatives are known from the Compendium of Herbicide Adjuvants, 10 th  Edition, Southern Illinois University, 2010. 
     The inventive compositions generally comprise from 0.1 to 99% by weight, especially from 0.1 to 95% by weight, of compounds of the present invention and from 1 to 99.9% by weight of a formulation adjuvant which preferably includes from 0 to 25% by weight of a surface-active substance. Whereas commercial products may preferably be formulated as concentrates, the end user will normally employ dilute formulations. 
     The rates of application vary within wide limits and depend on the nature of the soil, the method of application, the crop plant, the pest to be controlled, the prevailing climatic conditions, and other factors governed by the method of application, such as the time of application and the target crop. As a general guideline compounds may be applied at a rate of from 1 to 2000 I/ha, especially from 10 to 1000 I/ha. 
     Preferred formulations can have the following compositions (weight %): 
     Emulsifiable Concentrates:
         active ingredient: 1 to 95%, preferably 60 to 90%   surface-active agent: 1 to 30%, preferably 5 to 20%   liquid carrier: 1 to 80%, preferably 1 to 35%       

     Dusts:
         active ingredient: 0.1 to 10%, preferably 0.1 to 5%   solid carrier: 99.9 to 90%, preferably 99.9 to 99%       

     Suspension Concentrates:
         active ingredient: 5 to 75%, preferably 10 to 50%   water: 94 to 24%, preferably 88 to 30%   surface-active agent: 1 to 40%, preferably 2 to 30%       

     Wettable Powders:
         active ingredient: 0.5 to 90%, preferably 1 to 80%   surface-active agent: 0.5 to 20%, preferably 1 to 15%   solid carrier: 5 to 95%, preferably 15 to 90%       

     Granules:
         active ingredient: 0.1 to 30%, preferably 0.1 to 15%   solid carrier: 99.5 to 70%, preferably 97 to 85%       

     The following Examples further illustrate, but do not limit, the invention. 
     
       
         
           
               
               
               
               
             
               
                   
               
               
                 Wettable powders 
                 a) 
                 b) 
                 c) 
               
               
                   
               
             
            
               
                 active ingredients 
                 25% 
                 50% 
                 75% 
               
               
                 sodium lignosulfonate 
                  5% 
                  5% 
                 — 
               
               
                 sodium lauryl sulfate 
                  3% 
                 — 
                  5% 
               
               
                 sodium diisobutylnaphthalenesulfonate 
                 — 
                  6% 
                 10% 
               
               
                 phenol polyethylene glycol ether (7-8  
                 — 
                  2% 
                 — 
               
               
                 mol of ethylene oxide) 
                   
                   
                   
               
               
                 highly dispersed silicic acid 
                  5% 
                 10% 
                 10% 
               
               
                 Kaolin 
                 62% 
                 27% 
                 — 
               
               
                   
               
            
           
         
       
     
     The combination is thoroughly mixed with the adjuvants and the mixture is thoroughly ground in a suitable mill, affording wettable powders that can be diluted with water to give suspensions of the desired concentration. 
     
       
         
           
               
               
               
               
             
               
                   
               
               
                 Powders for dry seed treatment 
                 a) 
                 b) 
                 c) 
               
               
                   
               
             
            
               
                 active ingredients 
                 25% 
                 50% 
                 75% 
               
               
                 light mineral oil 
                  5% 
                  5% 
                  5% 
               
               
                 highly dispersed silicic acid 
                  5% 
                  5% 
                 — 
               
               
                 Kaolin 
                 65% 
                 40% 
                 — 
               
               
                 Talcum 
                 — 
                   
                 20% 
               
               
                   
               
            
           
         
       
     
     The combination is thoroughly mixed with the adjuvants and the mixture is thoroughly ground in a suitable mill, affording powders that can be used directly for seed treatment. 
     
       
         
           
               
             
               
                   
               
               
                 Emulsifiable concentrate 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                 active ingredients 
                 10% 
               
               
                   
                 octylphenol polyethylene glycol ether (4-5 mol of  
                  3% 
               
               
                   
                 ethylene oxide) 
                   
               
               
                   
                 calcium dodecylbenzenesulfonate 
                  3% 
               
               
                   
                 castor oil polyglycol ether (35 mol of ethylene  
                  4% 
               
               
                   
                 oxide) 
                   
               
               
                   
                 Cyclohexanone 
                 30% 
               
               
                   
                 xylene mixture 
                 50% 
               
               
                   
                   
               
            
           
         
       
     
     Emulsions of any required dilution, which can be used in plant protection, can be obtained from this concentrate by dilution with water. 
     
       
         
           
               
               
               
               
               
             
               
                   
                   
               
               
                   
                 Dusts 
                 a) 
                 b) 
                 c) 
               
               
                   
                   
               
             
            
               
                   
                 Active ingredients 
                  5% 
                  6% 
                  4% 
               
               
                   
                 Talcum 
                 95% 
                 — 
                 — 
               
               
                   
                 Kaolin 
                 — 
                 94% 
                 — 
               
               
                   
                 mineral filler 
                 — 
                 — 
                 96% 
               
               
                   
                   
               
            
           
         
       
     
     Ready-for-use dusts are obtained by mixing the combination with the carrier and grinding the mixture in a suitable mill. Such powders can also be used for dry dressings for seed. 
     
       
         
           
               
               
               
             
               
                   
                   
               
               
                   
                 Extruder granules 
                   
               
               
                   
                   
               
             
            
               
                   
                 Active ingredients 
                 15% 
               
               
                   
                 sodium lignosulfonate 
                  2% 
               
               
                   
                 carboxymethylcellulose 
                  1% 
               
               
                   
                 Kaolin 
                 82% 
               
               
                   
                   
               
            
           
         
       
     
     The combination is mixed and ground with the adjuvants, and the mixture is moistened with water. The mixture is extruded and then dried in a stream of air. 
     
       
         
           
               
               
               
             
               
                   
                   
               
               
                   
                 Coated granules 
                   
               
               
                   
                   
               
             
            
               
                   
                 Active ingredients 
                  8% 
               
               
                   
                 polyethylene glycol (mol. wt. 200) 
                  3% 
               
               
                   
                 Kaolin 
                 89% 
               
               
                   
                   
               
            
           
         
       
     
     The finely ground combination is uniformly applied, in a mixer, to the kaolin moistened with polyethylene glycol. Non-dusty coated granules are obtained in this manner. 
     Suspension Concentrate 
       
                                                active ingredients   40%           propylene glycol   10%           nonylphenol polyethylene glycol ether     6%           (15 mol of ethylene oxide)               Sodium lignosulfonate   10%           carboxymethylcellulose    1%           silicone oil (in the form of a 75% emulsion in     1%           water)               Water   32%                        
The finely ground combination is intimately mixed with the adjuvants, giving a suspension concentrate from which suspensions of any desired dilution can be obtained by dilution with water. Using such dilutions, living plants as well as plant propagation material can be treated and protected against infestation by microorganisms, by spraying, pouring or immersion.
 
     Flowable Concentrate for Seed Treatment 
     
       
         
           
               
               
             
               
                   
               
             
            
               
                 active ingredients 
                  40% 
               
               
                 propylene glycol 
                   5% 
               
               
                 copolymer butanol PO/EO 
                   2% 
               
               
                 Tristyrenephenole with 10-20 moles EO 
                   2% 
               
               
                 1,2-benzisothiazolin-3-one (in the form  
                 0.5% 
               
               
                 of a 20% solution in water) 
                   
               
               
                 monoazo-pigment calcium salt 
                   5% 
               
               
                 Silicone oil (in the form of a 75% emulsion in  
                 0.2% 
               
               
                 water) 
                   
               
               
                 Water 
                 45.3%  
               
               
                   
               
            
           
         
       
     
     The finely ground combination is intimately mixed with adjuvants, giving a suspension concentrate from which suspensions of any desired dilution can be obtained by dilution with water. Using such dilutions, living plants as well as plant propagation material can be treated and protected against infestation by microorganisms, by spraying, pouring or immersion. 
     Slow Release Capsule Suspension 
     28 parts of the combination are mixed with 2 parts of an aromatic solvent and 7 parts of toluene diisocyanate/polymethylene-polyphenylisocyanate-mixture (8:1). This mixture is emulsified in a mixture of 1.2 parts of polyvinylalcohol, 0.05 parts of a defoamer and 51.6 parts of water until the desired particle size is achieved. To this emulsion a mixture of 2.8 parts 1,6-diaminohexane in 5.3 parts of water is added. The mixture is agitated until the polymerization reaction is completed. The obtained capsule suspension is stabilized by adding 0.25 parts of a thickener and 3 parts of a dispersing agent. The capsule suspension formulation contains 28% of the active ingredients. The medium capsule diameter is 8-15 microns. The resulting formulation is applied to seeds as an aqueous suspension in an apparatus suitable for that purpose. 
     Formulation types include an emulsion concentrate (EC), a suspension concentrate (SC), a suspo-emulsion (SE), a capsule suspension (CS), a water dispersible granule (WG), an emulsifiable granule (EG), an emulsion, water in oil (EO), an emulsion, oil in water (EW), a micro-emulsion (ME), an oil dispersion (OD), an oil miscible flowable (OF), an oil miscible liquid (OL), a soluble concentrate (SL), an ultra-low volume suspension (SU), an ultra-low volume liquid (UL), a technical concentrate (TK), a dispersible concentrate (DC), a wettable powder (WP), a soluble granule (SG) or any technically feasible formulation in combination with agriculturally acceptable adjuvants. 
    
    
     PREPARATORY EXAMPLES 
     Lcms Methods: 
     Method 1: 
     Spectra were recorded on a ZQ Mass Spectrometer from Waters (Single quadrupole mass spectrometer); Instrument Parameter: Ionisation method: Electrospray Polarity: positive (negative) ions; Capillary (kV) 3.00, Cone (V) 30.00, Extractor (V) 2.00, Gas Temperature (° C.) 350, Drying Gas Flow (mL/min) 9.8, Neb press 45 psig, Mass range: 90 to 1000 Da. 
     LC: HP 1100 HPLC from Agilent: solvent degasser, quaternary pump (ZCQ)/binary pump (ZDQ), heated column compartment and diode-array detector. Column: porpshell 120 C 18 , 2.7 m particle size, 120 Angström, 4.6×50 mm; Temp: 30° C. DAD Wavelength range (nm): 190 to 400 Solvent Gradient: A=water+n 0.1% HCOOH. B=Acetonitrile+0.8% HCOOH 
     
       
         
           
               
               
               
               
               
             
               
                   
                   
               
               
                   
                 Time (min) 
                 A % 
                 B %  
                 Flow (ml/min) 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 0.00 
                 85.0 
                 15.0 
                 0.6 
               
               
                   
                 4.00 
                 5.00 
                 95.00 
                 0.6 
               
               
                   
                 10.00 
                 5.00 
                 95.00 
                 0.6 
               
               
                   
                   
               
            
           
         
       
     
     Method 2: 
     Spectra were recorded on a ACQUITY Mass Spectrometer from Waters Corporations (SQD or SQDII Single quadrupole mass spectrometer) equipped with an electrospray source (Polarity: positive or negative ions, Capillary: 3.0 kV, Cone: 30V, Extractor: 3.00 V, Source Temperature: 150° C., Desolvation Temperature: 400° C., Cone Gas Flow: 60 L/hr, Desolvation Gas Flow: 700 L/hr, Mass range: 140 to 800 Da) and an ACQUITY UPLC from Waters Corporations with solvent degasser, binary pump, heated column compartment and diode-array detector. Column: Waters UPLC HSS T3, 1.8 μm, 30×2.1 mm, Temp: 60° C., DAD Wavelength range (nm): 210 to 400, Solvent Gradient: A=Water/Methanol 9:1+0.1% formic acid, B=Acetonitrile+0.1% formic acid, gradient: 0-100% B in 2.5 min; Flow (ml/min) 0.75. 
     Method 3: 
     Spectra were recorded on a Mass Spectrometer from Waters (SQD, SQDII Single quadrupole mass spectrometer) equipped with an electrospray source (Polarity: positive and negative ions, Capillary: 3.00 kV, Cone range: 30 V, Extractor: 2.00 V, Source Temperature: 150° C., Desolvation Temperature: 350° C., Cone Gas Flow: 50 I/h, Desolvation Gas Flow: 650 I/h, Mass range: 100 to 900 Da) and an Acquity UPLC from Waters: Binary pump, heated column compartment, diode-array detector and ELSD detector. Column: Waters UPLC HSS T3, 1.8 m, 30×2.1 mm, Temp: 60° C., DAD Wavelength range (nm): 210 to 500, Solvent Gradient: A=water+5% MeOH+0.05% HCOOH, B=Acetonitrile+0.05% HCOOH, gradient: 10-100% B in 1.2 min; Flow (ml/min) 0.85. 
     The following abbreviations are used in the experimental description below: s=singlet, d=doublet, t=triplet, q=quartet, m=multiplet, RT=retention time, min=minutes. 
     Example P1: 5-[4-(5-methyl-1,2,4-oxadiazol-3-yl)Piperidine-1-carbonyl]-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]benzonitrile (Compound P1.1) 
     
       
         
         
             
             
         
       
     
     Step 1: Methyl 4-hydroxy-5-iodo-2-(trifluoromethyl)benzoate 
     
       
         
         
             
             
         
       
     
     Methyl 4-hydroxy-2-(trifluoromethyl)benzoate (10.5 g, 47.7 mmol), iodine (18.0 g, 70.9 mmol) and potassium carbonate (13.2 g, 95.5 mmol) were added to THE (150 mL). The reaction mixture was heated under reflux for 16 hours. Then sodium thiosulfate solution was added. The mixture was extracted with ethyl acetate, and the organic phase was washed three times with brine. The solvent was evaporated and the residue was purified by chromatography (petroleum ether: ethyl acetate=5:1) to give a white solid (6.90 g, 41.8%).  1 H-NMR [ppm] in DMSO-d6: 11.75 (s, 1H), 8.23 (s, 1H), 7.23 (s, 1H), 3.81 (s, 3H). LC-MS (method 1): RT=4.34 min; [M−H] − =344.9. 
     Step 2: Methyl 5-cyano-4-hydroxy-2-(trifluoromethyl)benzoate 
     
       
         
         
             
             
         
       
     
     Methyl 4-hydroxy-5-iodo-2-methyl-benzoate (2.50 g, 8.56 mmol) and copper (I) cyanide (1.94 g, 21.7 mmol) were stirred in 1-methylpyrrolidin-2-one (20 mL) at 110° C. for 12 hours. The mixture was poured into water and extracted with ethyl acetate (50 mL), dried over Na 2 SO 4 , filtered and concentrated under vacuum. The crude product was purified by column chromatography on silica gel (ethyl acetate/petroleum ether=1/5) to give a white solid (1.30 g, 73.4%).  1 H-NMR [ppm] in DMSO-d6: 12.75 (bs, 1H), 8.23 (s, 1H), 7.40 (s, 1H), 3.83 (s, 3H). LC-MS (method 1): RT=3.88 min; [M−H]−=244. 
     Step 3: Methyl 5-cyano-2-(trifluoromethyl)-4-(trifluoromethylsulfonyloxy)benzoate 
     
       
         
         
             
             
         
       
     
     Into the reaction vessel was added methyl 5-cyano-4-hydroxy-2-(trifluoromethyl)benzoate (1.00 g, 4.08 mmol), dichloromethane (20 mL), and pyridine (0.968 g, 12.2 mmol), The reaction mixture was cooled to 0° C. and triflic anhydride (2.88 g, 10.2 mmol). The reaction mixture was allowed to warm to room temperature, stirred at room temperature for 30 minutes, cooled to 0° C. Dichloromethane (30 mL) and water (50 mL) were added. The organic phase was collected, dried over Na 2 SO 4 , concentrated under reduced pressure, and subjected to silica gel chromatography purification (ethyl acetate/petroleum ether=1:10) to give colorless oil (1.38 g, 90.0%).  1 H-NMR [ppm] in DMSO-d6: 8.70 (s, 1H), 8.46 (s, 1H), 3.92 (s, 3H). 
     Step 4: Methyl 5-cyano-2-(trifluoromethyl)-4-[4-(trifluoromethyl)phenyl]benzoate 
     
       
         
         
             
             
         
       
     
     A mixture of methyl 5-cyano-2-(trifluoromethyl)-4-(trifluoromethylsulfonyloxy)benzoate (1.75 g, 4.64 mmol), [4-(trifluoromethyl)phenyl]boronic acid (1.76 g, 9.28 mmol), tetrakis(triphenylphosphine)-palladium(0) (0.536 g, 0.464 mmol), potassium carbonate (1.6 g, 11.6 mmol) in 1,4-dioxane (30.0 mL) was stirred at 110° C. under nitrogen atmosphere for 16 hours. The reaction mixture was poured into water and extracted with ethyl acetate three times. The combined organic layers were dried over Na2SO 4 , filtered and concentrated under vacuum. The crude product was purified by column chromatography on silica gel to give a white solid (1.50 g, 86.6%).  1 H-NMR [ppm] in DMSO-d6: 8.53 (s, 1H), 8.17 (s, 1H), 7.90-8.10 (m, 4H), 3.93 (s, 3H). 
     Step 5: 5-Cyano-2-(trifluoromethyl)-4-[4-(trifluoromethyl)phenyl]benzoate 
     
       
         
         
             
             
         
       
     
     Sodium hydroxide (0.643 g, 16.1 mmol) in water (5 mL) was added dropwise to a solution of methyl 5-cyano-2-(trifluoromethyl)-4-[4-(trifluoromethyl)phenyl]benzoate (2.00 g, 5.36 mmol) in methanol (10 mL) and water (5 mL). Tetrahydrofuran (10 mL) was added after 5 minutes. The mixture was stirred at room temperature for 2 hours. The reaction mixture was poured into aqueous hydrochloric acid and extracted with ethyl acetate (50 mL), dried over Na 2 SO 4 , filtered and concentrated under vacuum to give white solid (1.40 g, 72.7%).  1 H-NMR [ppm] in DMSO-d6: 8.46 (s, 1H), 8.11 (s, 1H), 7.90-8.10 (m, 4H). This material was used for next step. 
     Step 6: 5-[4-(5-Methyl-1,2,4-oxadiazol-3-yl)piperidine-1-carbonyl]-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]benzonitrile (Compound P1.1) 
     
       
         
         
             
             
         
       
     
     To a solution of 5-cyano-2-(trifluoromethyl)-4-[4-(trifluoromethyl)phenyl]benzoic acid (200 mg, 0.557 mmol) in dichloromethane (10.0 mL) was added the hydrochloride salt of 5-methyl-3-(4-piperidyl)-1,2,4-oxadiazole (126 mg, 0.618 mmol, 1.11 eq) which was synthesized as described in Nippon Soda patent application WO 2017195703. Subsequently HATU (234 mg, 0.615 mmol, 1.11eq) and diisopropyl-ethyl-amine (216 mg, 1.68 mmol, 3.01 eq) were added. The reaction mixture was stirred at room temperature for 21 hours and then poured into an aqueous NaHCO 3  solution. The mixture was extracted three times with ethyl acetate. The water layer was acidified with 2N hydrochloric acid and extracted three times with ethyl acetate. The combined organic layers were washed with brine, dried over Na 2 SO 4 , filtered and concentrated under reduced pressure. The residue was purified via chromatography (ethyl acetate/petroleum ether=1:2) to give 205 mg (yield: 72%) of 5-[4-(5-methyl-1,2,4-oxadiazol-3-yl)piperidine-1-carbonyl]-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]benzonitrile as a white solid.  1 H-NMR [ppm] in CDCl 3 : 7.85 (d, 2H), 7.82-7.74 (m, 2H), 7.70 (d, 2H), 4.64 (s, 1H), 3.49 (d, 1H), 3.31-3.02 (m, 3H), 2.59 (d, 3H), 2.19 (d, 1H), 2.06-1.79 (m, 3H). 7.74-7.88 (m, 4H), 7.70 (d, 2H), 4.60 (t, 1H), 3.50 (t, 1H), 3.02-3.40 (m, 3H), 2.57 (d, 3H), 2.10-2.25 (m, 1H), 1.79-2.06 (m, 3H). LC-MS (method 1): RT=4.80 min; [M+H] + =509. 
     Example P2: 5-[4-(3,5-Dichloro-2-pyridyl)piperazine-1-carbonyl]-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]benzonitrile (Compound P2.1) 
     
       
         
         
             
             
         
       
     
     To a solution of 5-cyano-2-(trifluoromethyl)-4-[4-(trifluoromethyl)phenyl]benzoic acid (158 mg, 0.44 mmol) in DMF (5 mL) was added 4-(3,5-dichloro-2-pyridyl)piperazine (108 mg, 0.463 mmol), HATU (201 mg, 0.528 mmol) and diisopropylethylamine (227 mg, 1.76 mmol). The reaction mixture was stirred at room temperature for 16 hours. Then the mixture was poured into water and extracted with ethyl acetate three times. The combined organic layer were washed two times with water and once with brine, dried over Na 2 SO 4  and the solvent was removed. The crude product was purified by chromatography on silica gel (ethyl acetate/petroleum ether=1:1) to give the product (187 mg, 74%) as a white solid.  1 H-NMR [ppm] in CDCl 3 : 8.16 (s, 1H), 7.88 (s, 1H), 7.76-7.85 (m, 3H), 7.71 (d, 2H), 7.70 (s, 1H), 3.85-4.10 (m, 2H), 3.25-3.53 (m, 6H). LC-MS (method 1): RT=5.51 min; [M+H] + =574. 
     Example P3: 5-[4-(3,5-Dichloro-2-pyridyl)piperazine-1-carbonyl]-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]benzenecarbothioamide (Compound P8.1) 
     
       
         
         
             
             
         
       
     
     To a solution of 5-[4-(3,5-dichloro-2-pyridyl)piperazine-1-carbonyl]-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]benzonitrile (0.134 g, 0.234 mmol) in DMF (2.3 mL) was added magnesium dichloride (0.062 g, 0.304 mmol, 1.3 eq). The mixture was stirred for 1 hour at room temperature. Then sodium hydrosulfide (0.05 g, 0.888 mmol, 3.8 eq) was added and stirring was continued for 1 hour at room temperature. The reaction mixture was treated with saturated aqueous NHCl 4  solution and then extracted three times with ethyl acetate. The organic phase was dried over Na2SO 4  and the solvent was removes solvent under reduced pressure. The residue was purified by chromatography to give the desired product (130 mg, 91%) as a white foam.  1 H-NMR [ppm] in CDCl 3 : 8.18 (s, 1H), 7.62-7.80 (m, 7H), 7.01 (bs, 1H), 6.97 (bs, 1H), 3.85-4.10 (m, 2H), 3.25-3.60 (m, 6H). LC-MS (method 2): RT=1.25 min; [M+H] + =607. 
     Example P4: 5-[4-(3,5-Dichloro-2-pyridyl)piperazine-1-carbonyl]-4-ethoxy-2-[4-(trifluoromethyl)-phenyl]-benzonitrile (Compound P2.5) 
     
       
         
         
             
             
         
       
     
     Step 1: Ethyl 4-amino-5-cyano-2-hydroxy-benzoate 
     
       
         
         
             
             
         
       
     
     To a solution of sodium ethoxide (1.1 eq.) in ethanol (20% w/w) was added slowly propanedinitrile (1.32 g, 20 mmol, 1 eq) at 4° C. and the mixture was stirred for 15 minutes. Then a solution ethyl (2E)-2-(ethoxymethylene)-3-oxo-butanoate (3.72 g, 20 mmol) in ethanol (50 mL) was added under ice cooling. The reaction mixture was heated to reflux for 1 hour. After cooling the reaction mixture was diluted with ethyl acetate and water. The phases were separated and the aqueous phase was extracted three times with ethyl acetate. The combined organic layer was washed two times with water and once with brine, dried over Na 2 SO 4  and the solvent was removed. 2.45 g (59% yield) of ethyl 4-amino-5-cyano-2-hydroxy-benzoate were obtained as a white solid.  1 H NMR [ppm] in DMSO: 10.98 (s, 1H), 7.89 (s, 1H), 6.79 (s, 2H), 6.20 (s, 1H), 4.28 (q, 2H), 1.30 (t, 3H). LC-MS (method 1): RT=3.98 min; [M+H] + =207. 
     Step 2: Ethyl 5-cyano-2-hydroxy-4-iodo-benzoate 
     
       
         
         
             
             
         
       
     
     To a solution of boron trifluoride diethyl etherate (568 mg, 4 mmol) in THE (5 mL) was added a solution of ethyl 4-amino-5-cyano-2-hydroxy-benzoate (412 mg, 4 mmol) in THE (5 mL) at 0° C. Then the mixture was cooled to −10° C., tert-butyl nitrite (268 mg, 2.6 mmol) was added and the reaction mixture was stirred at −10° C. for 0.5 hours. Then sodium iodide (390 mg, 2.6 mmol) in acetone (10 mL) was added and the mixture was stirred at room temperature for 1.5 hours. The reaction mixture was diluted with ethyl acetate and water. The phases were separated, and the aqueous phase was extracted three times with ethyl acetate. The combined organic layer was washed two times with water and once with brine, dried over Na 2 SO 4  and the solvent was removed. The crude product was purified by chromatography on silica gel (ethyl acetate/petroleum ether=1:2) to afford the product (599 mg, 94.5%) as a white solid.  1 H NMR [ppm] in DMSO-d6: 11.36 (s, 1H), 8.07 (s, 1H), 7.63 (s, 1H), 4.32 (q, 2H), 1.32 (t, 3H). LC-MS (method 1): RT=4.76 min; [M+H] + =318. 
     Step 3: Ethyl 5-cyano-2-ethoxy-4-iodo-benzoate 
     
       
         
         
             
             
         
       
     
     To a solution of ethyl 5-cyano-2-hydroxy-4-iodo-benzoate (1.17 g, 3.7 mmol) in acetone (50 mL) was added iodoethane (867 mg, 5.56 mmol) and potassium carbonate (767 mg, 5.56 mmol). The mixture was stirred and heated to reflux for 5 hours. After cooling, the reaction mixture was diluted with ethyl acetate and water. The phases were separated and the aqueous phase was extracted three times with ethyl acetate. The combined organic layer was washed two times with water and once with brine, dried over Na 2 SO 4  and the solvent was removed. The crude product was purified by chromatography on silica gel (ethyl acetate/petroleum ether=1:5) to afford the product (372 mg, 29%) as a white solid.  1 H NMR [ppm] in CDCl 3 : 7.99 (s, 1H), 7.45 (s, 1H), 4.35 (q, 2H), 4.16 (q, 2H), 1.49 (t, 3H), 1.38 (t, 3H). LC-MS (method 1): RT=4.683 min; [M+H] + =346. 
     Step 4: Ethyl 5-cyano-2-ethoxy-6-[4-(trifluoromethyl)phenyl]pyridine-3-carboxylate 
     
       
         
         
             
             
         
       
     
     A mixture of ethyl 5-cyano-2-ethoxy-6-iodo-pyridine-3-carboxylate (370 mg, 1.07 mmol), 1-[4-(trifluoromethyl)phenyl]boronic acid (408 mg, 2.14 mmol), Pd(PPh 3 ) 4  (247 mg, 0.21 mmol) and potassium carbonate (443 mg, 3.21 mmol) in 1,4-dioxane (20.0 mL) was stirred under nitrogen at 90° C. for 16 hours. Then the mixture was poured into water and extracted with ethyl acetate three times. The combined organic layer was washed two times with water and once with brine, dried over Na 2 SO 4  and the solvent was removed. The crude product was purified by chromatography on silica gel (ethyl acetate/petroleum ether=1:5) to give the product (380 mg, 97.5%) as a white solid.  1 H NMR [ppm] in CDCl 3 : 8.22 (s, 1H), 7.77 (d, 2H), 7.68 (d, 2H), 7.01 (s, 1H), 4.40 (q, 2H), 4.22 (q, 2H), 1.52 (t, 3H), 1.41 (t, 3H). LC-MS (method 1): RT=3.615 min; [M+H] + =364. 
     Step 5: 5-Cyano-2-ethoxy-4-[4-(trifluoromethyl)phenyl]benzoic Acid 
     
       
         
         
             
             
         
       
     
     Ethyl 5-cyano-2-ethoxy-4-[4-(trifluoromethyl)phenyl]benzoate (1.3 g, 3.58 mmol) was dissolved in tetrahydrofuran (10 mL) and potassium hydroxide (429 mg, 10.7 mmol, 3.0 eq.) dissolved in water (2 mL) was added. The reaction mixture was stirred at room temperature for 16 hours. Then the reaction mixture was diluted with ethyl acetate and 2 N hydrochloric acid. The mixture was extracted three times with ethyl acetate. The combined organic layer was washed two times with water and once with brine, dried over Na 2 SO 4  and the solvent was removed to give the crude product (1.2 g, 100%) as a white solid witch was used directly for the next step. 
     Step 6: 5-[4-(3,5-Dichloro-2-pyridyl)piperazine-1-carbonyl]-4-ethoxy-2-[4-(trifluoromethyl)-phenyl]-benzonitrile (Compound P2.5) 
     
       
         
         
             
             
         
       
     
     To a solution of 5-cyano-2-ethoxy-4-[4-(trifluoromethyl)phenyl]benzoic acid (121 mg, 0.36 mmol) in DMF (5 mL) was added 1-(3,5-dichloro-2-pyridyl)piperazine (99 mg, 0.43 mmol), HATU (163 mg, 0.43 mmol) and diisopropylethylamine (139 mg, 1.08 mmol). The reaction mixture was stirred at room temperature for 16 hours. Then the mixture was poured into water and extracted with ethyl acetate three times. The combined organic layer was washed two times with water and once with brine, dried over Na 2 SO 4  and the solvent was removed. The crude product was purified by chromatography on silica gel (ethyl acetate/petroleum ether=1/1) to give the product (140 mg, 71%) as a white solid.  1 H NMR [ppm] in CDCl 3 : 8.16 (d, 1H), 7.74 (d, 2H), 7.71 (s, 1H), 7.64-7.68 (m, 3H), 6.97 (s, 1H), 4.15-4.25 (m, 2H), 3.80-4.20 (m, 2H), 1.48 (t, 3H). LC-MS (method 1): RT=5.627 min; [M+H] + =550. 
     Example P5: 4-Ethoxy-5-[4-(ethylsulfanylmethyl)piperidine-1-carbonyl]-2-[4-(trifluoromethyl)phenyl]-benzonitrile (Compound P1.46) 
     
       
         
         
             
             
         
       
     
     To a solution of 5-cyano-2-ethoxy-4-[4-(trifluoromethyl)phenyl]benzoic acid (140 mg, 0.42 mmol) in DMF (5 mL) was added 4-(ethylsulfanylmethyl)piperidine hydrochloride (117 mg, 0.598 mmol), HATU (190 mg, 0.5 mmol) and diisopropylethylamine (163 mg, 1.62 mmol). The reaction mixture was stirred at room temperature for 16 hours. Then the mixture was poured into water and extracted with ethyl acetate three times. The combined organic layer was washed two times with water and once with brine, dried over Na 2 SO 4  and the solvent was removed. The crude product was purified by chromatography on silica gel (ethyl acetate/petroleum ether=1:1) to give the product (127 mg, 64%) as a white solid.  1 H NMR [ppm] in CDCl 3 : 7.76 (d, 2H), 7.60-7.70 (m, 3H), 6.94 (d, 1H), 4.78 (t, 1H), 4.09-4.25 (m, 2H), 3.49 (d, 1H), 2.90-3.10 (m, 1H), 2.79 (q, 1H), 2.42-2.59 (m, 4H), 1.90-2.05 (m, 1H), 1.69-1.85 (m, 2H), 1.40-1.51 (m, 3H), 1.20-1.30 (m, 5H). LC-MS (method 1): RT=5.32 min; [M+H] + =477. 
     Example P6: 4-Ethoxy-5-[4-(ethylsulfanylmethyl)piperidine-1-carbonyl]-2-[4-(trifluoromethyl)phenyl]-benzonitrile (Compound P3.7) 
     
       
         
         
             
             
         
       
     
     Step 1: tert-Butyl 3-(acetylsulfanylmethyl)azetidine-1-carboxylate 
     
       
         
         
             
             
         
       
     
     Acetyl sulfanyl sodium (85.0%, 0.462 g, 4.00 mmol) was added to the tert-butyl 3-(bromomethyl)-azetidine-1-carboxylate (0.500 g, 2.00 mmol) in acetone (10.0 mL) at room temperature and the mixture was stirred at room temperature for 16 hours. Then the mixture was poured into dilute hydrochloric acid and extracted with ethyl acetate three times. The combined organic layers were dried over Na 2 SO 4 , filtered and concentrated under vacuum. The crude product was purified by column chromatography on silica gel (petroleum ether/ethyl acetate=20:1) to afford 315 mg (yield: 64%) tert-butyl 3-(acetylsulfanylmethyl)-azetidine-1-carboxylate.  1 H NMR [ppm] in CDCl 3 : 3.98 (t, 2H), 3.56 (dd, 2H), 3.09 (d, 2H), 2.62-2.78 (m, 1H), 2.34 (s, 3H), 1.42 (d, 9H). LC-MS (method 1): RT=4.25 min; [M+Na] + =268. 
     Step 2: tert-Butyl 3-(sulfanylmethyl)azetidine-1-carboxylate 
     
       
         
         
             
             
         
       
     
     Sodium borohydride (0.308 g, 8.15 mmol) was added to tert-butyl 3-(acetylsulfanylmethyl)azetidine-1-carboxylate (1.00 g, 4.08 mmol) in methanol (10.0 mL) and stirred for 16 hours at room temperature. Then the mixture was poured into dilute hydrochloric acid and extracted with ethyl acetate three times. The combined organic layers were dried over Na 2 SO 4 , filtered and concentrated under vacuum. The crude product was purified by column chromatography on silica gel (petroleum ether/ethyl acetate=20:1) to afford 528 mg (yield: 64%) tert-butyl 3-(sulfanylmethyl)azetidine-1-carboxylate.  1 H NMR [ppm] in CDCl 3 : 4.02 (t, 2H), 3.60 (dd, 2H), 2.73 (t, 2H), 2.61-2.65 (m, 1H), 1.43 (s, 9H), 1.30 (t, 1H). LC-MS (method 1): RT=4.11 min; [M+Na] + =226. 
     Step 3: tert-Butyl 3-(propylsulfanylmethyl)azetidine-1-carboxylate 
     
       
         
         
             
             
         
       
     
     1-Iodopropane (0.627 g, 3.69 mmol) was added to tert-butyl 3-(sulfanylmethyl)azetidine-1-carboxylate (500 mg, 2.46 mmol) and K 2 CO 3  (1.02 g, 7.38 mmol) in acetone (10.0 mL) and the reaction mixture was stirred for 16 hours at room temperature. Then the mixture was poured into dilute hydrochloric acid and extracted with ethyl acetate three times. The combined organic layers were dried over Na 2 SO 4 , filtered and concentrated under vacuum. The crude product was purified by column chromatography on silica gel (petroleum ether/ethyl acetate=20:1) to afford 331 mg (yield: 52%) of tert-butyl 3-(propylsulfanylmethyl)azetidine-1-carboxylate.  1 H NMR [ppm] in CDCl 3 : 4.02 (t, 2H), 3.60 (dd, 2H), 2.60-2.75 (m, 3H), 2.47 (t, 2H), 1.54-1.63 (m, 2H), 1.43 (s, 9H), 0.98 (t, 3H). 
     Step 4: Trifluoroacetic acid salt of 3-(propylsulfanylmethyl)azetidine 
     
       
         
         
             
             
         
       
     
     tert-Butyl 3-(propylsulfanylmethyl)azetidine-1-carboxylate (500 mg, 2.04 mmol) and 2,2,2-trifluoroacetic acid (0.929 g, 8.15 mmol) in dichloromethane (15.0 mL) was stirred at room temperature for 16 hours. The reaction mixture was concentrated under vacuum and used for the next step.  1 H NMR [ppm] in DMSO-d6: 4.17 (s, 2H), 3.90 (s, 2H), 3.13 (t, 1H), 2.78 (d, 2H), 2.48 (t, 2H), 1.64-1.52 (m, 2H), 0.98 (t, 3H). 
     Step 5: 5-[3-(propylsulfanylmethyl)azetidine-1-carbonyl]-4-(trifluoromethyl)-2-[4-(trifluoromethyl)-phenyl]benzonitrile 
     
       
         
         
             
             
         
       
     
     To a solution of 5-cyano-2-(trifluoromethyl)-4-[4-(trifluoromethyl)phenyl]benzoic acid (150 mg, 0.418 mmol) in DMF (5 mL) was added the trifluoroacetic acid salt of 3-(propylsulfanylmethyl)azetidine (162 mg, 0.626 mmol, 1.5eq). Subsequently HATU (238 mg, 0.626 mmol, 1.5 eq.) and diisopropylethylamine (162 mg, 1.25 mmol, 3.00 eq.) were added. The reaction mixture was stirred at room temperature for 16 hours and then poured into an aqueous NaHCO 3  solution. The mixture was extracted three times with ethyl acetate. The water layer was acidified with 2N hydrochloric acid and extracted three times with ethyl acetate. The combined organic layers were washed with brine, dried over Na 2 SO 4 , filtered and concentrated under reduced pressure. The residue was purified via chromatography (petroleum ether/ethyl acetate=1:1) to afford 121 mg (yield: 60%) of 5-[3-(propylsulfanylmethyl)azetidine-1-carbonyl]-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]-benzonitrile were obtained as a colorless gum.  1 H-NMR [ppm] in CDCl 3 ): 7.85 (s, 1H), 7.77-7.83 (m, 3H), 7.69 (d, 2H), 4.33 (t, 1H), 4.05 (t, 1H), 3.92 (dd, 1H), 3.66 (dd, 1H), 2.65-2.99 (m, 3H), 2.40-2.60 (m, 2H), 1.55-1-70 (m, 2H), 0.98 (t, 3H). LC-MS (method 1): RT=5.38 min; [M+H] + =487. 
     Step 6: 5-[3-(Propylsulfinylmethyl)azetidine-1-carbonyl]-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]-benzonitrile (Compound P3.7) 
     
       
         
         
             
             
         
       
     
     3-Chloro-perbenzoic acid (0.034 g, 0.197 mmol, 0.8 eq) was added to 5-[3-(propylsulfanylmethyl)-azetidine-1-carbonyl]-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]benzonitrile (120 mg, 0.247 mmol) in dichloromethane (20 mL) and stirred for 2 hours at room temperature. Then the mixture was poured into a saturated solution of NaHCO 3  and Na 2 SO 3  in water and extracted with ethyl acetate three times. The combined organic layers were dried over Na 2 SO 4 , filtered and concentrated under vacuum. The crude product was purified by column chromatography on silica gel (ethyl acetate/petroleum ether=1:2) to give 41 mg (yield: 33%) of 5-[3-(propylsulfinylmethyl)azetidine-1-carbonyl]-4-(trifluoromethyl)-2-[4-(trifluoromethyl)phenyl]benzonitrile as a colorless gum.  1 H-NMR [ppm] in DMSO-d6): 8.32 (s, 1H), 8.09 (s, 1H), 7.88-7.96 (m, 4H), 4.24 (t, 1H), 4.05-4.15 (m, 1H), 3.68-3.97 (m, 1H), 3.82 (dd, 1H), 2.96-3.20 (m, 3H), 2.60-2.75 (m, 2H), 1.53-1.71 (m, 2H), 0.98 (t, 3H). LC-MS (method 1): RT=4.36 min; [M+H] + =503. 
     Example P7: 4-Methyl-5-[4-(5-methyl-1,2,4-oxadiazol-3-yl)piperazine-1-carbonyl]-2-[4-(trifluoromethyl)phenyl]benzene-1,3-dicarbonitrile (Compound P6.1) 
     
       
         
         
             
             
         
       
     
     Step 1: Ethyl 4-amino-3,5-dicyano-2-methyl-benzoate 
     
       
         
         
             
             
         
       
     
     A solution of ethyl acetoacetate (1.3 mL, 0.01 mmol) in methanol was cooled to 0° C., then treated with aqueous formaldehyde (1 mL). The reaction mixture was stirred for 3 hours and then a solution of malononitrile (1.2 g, 0.2 mmol) in methanol (30 mL) was added gradually with stirring over a period of 1 hour after which time a morpholine solution (0.8 mL, 0.1 mmol) in methanol (20 mL) was added to the mixture. This mixture was cooled with ice for 3 hours, then allowed to stand at room temperature for 48 hours. The solid was filtered off and washed with a small amount of methanol to give the target compound (1.8 g, 78%).  1 H-NMR [ppm] in CDCl 3 : 8.02 (s, 1H), 7.17 (s, 2H), 4.26 (q, 2H), 2.65 (s, 3H), 1.35 (t, 3H). MS (ESI) [M+H] + =230.0. 
     Step 2: Ethyl 3,5-dicyano-4-iodo-2-methyl-benzoate 
     
       
         
         
             
             
         
       
     
     Ethyl 4-amino-3,5-dicyano-2-methyl-benzoate (1.90 g, 8.3 mmol) was suspended in H 2 SO 4  (40 mL, 50%), cooled to −5° C. and stirred for 1 hour. A solution of sodium nitrite (0.86 g, 12.5 mmol) in water (5 mL) was added slowly, and the mixture stirred for 30 minutes at 0° C. The yellow slurry was then slowly added to an ice-cooled solution of potassium iodide (13.8 g, 83 mmol) in water (230 mL). The ice bath was then removed, and the foamy suspension was stirred for 2 hours at room temperature. Dichloromethane (100 mL) was added, followed by a saturated Na 2 S 2 O 3  solution. The organic layer was separated, and the aqueous layer was extracted with dichloromethane. The combined dichloromethane layer was dried over Na 2 SO 4 , the solvent was evaporated to yield ethyl 3,5-dicyano-4-iodo-2-methyl-benzoate. (0.8 g, 28%).  1 H-NMR [ppm] in CDCl 3 : 8.27 (s, 1H), 4.20 (q, 2H), 2.50 (s, 3H), 1.42 (t, 3H). MS (ESI) [M+H] + =341.1. 
     Step 3: Ethyl 3,5-dicyano-2-methyl-4-[4-(trifluoromethyl)phenyl]benzoate 
     
       
         
         
             
             
         
       
     
     The mixture of ethyl 3,5-dicyano-4-iodo-2-methyl-benzoate (0.74 g, 2.18 mmol), [4-(trifluoromethyl)phenyl]boronic acid (0.62 g, 3.26 mmol), sodium carbonate (0.46 g, 4.33 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.25 g, 0.218 mmol) in toluene (20 mL)/water (6 mL) was stirred at 80° C. overnight. The reaction mixture was cooled to room temperature and extracted with ethyl acetate. The organic layer was separated, washed with brine (20 mL), dried over magnesium sulfate and concentrated in vacuum. Purification through column chromatography (ethyl acetate/petroleum ether=2:1) gave the target compound (0.7 g, 90%).  1 H-NMR [ppm] in CDCl 3 : 8.45 (s, 1H), 7.84 (d, 2H), 7.64 (d, 2H), 4.46 (q, 2H), 2.97 (s, 3H), 1.45 (t, 3H). MS (ESI) [M+H] + =359.3. 
     Step 4: 3,5-dicyano-2-methyl-4-[4-(trifluoromethyl)phenyl]benzoic Acid 
     
       
         
         
             
             
         
       
     
     A solution of ethyl 3,5-dicyano-2-methyl-4-[4-(trifluoromethyl)phenyl]benzoate (0.56 g, 1.56 mmol) in methanol (10 mL), sodium hydroxide (75 mg, 1.88 mmol) was added. The mixture was stirred at room temperature for 2 hours. Then the pH was adjusted to 2-3 by addition of hydrochloric acid and the mixture was extracted with ethyl acetate. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in vacuum to give the product (0.5 g, 97%).  1 H-NMR [ppm] in DMSO-d6: 8.57 (s, 1H), 8.02 (d, 2H), 7.87 (d, 2H), 2.83 (s, 3H). MS (ESI) [M+H] + =331.3. 
     Step 5: 4-Methyl-5-[4-(5-methyl-1,2,4-oxadiazol-3-yl)piperazine-1-carbonyl]-2-[4-(trifluoromethyl)-phenyl]benzene-1,3-dicarbonitrile (Compound P6.1) 
     
       
         
         
             
             
         
       
     
     A mixture of 3,5-dicyano-2-methyl-4-[4-(trifluoromethyl)phenyl]benzoic acid (250 mg, 0.757 mmol), 5-methyl-3-(4-piperidyl)-1,2,4-oxadiazole (127 mg, 0.757 mmol) which was synthesized as described in Nippon Soda patent application WO 2017195703, diisopropylethylamine (294 mg, 2.27 mmol) and HATU (431 mg, 1.14 mol) in dichloromethane (10 mL) was stirred at room temperature for 4 hours. The mixture was poured into water (50 mL) and the mixture extracted three times with ethyl acetate (50 mL each), the combined organic phases were dried over Na 2 SO 4  and concentrated. The material was purified by chromatography (ethyl acetate/petroleum ether=1:2) to give the title compound as solid (230 mg, 63%).  1 H-NMR [ppm] in CDCl 3 : 7.84 (d, 2H), 7.76, 7.79 (2s, 1H), 7.63 (d, 2H), 4.63 (t, 1H), 3.53 (d, 1H), 3.10-3.30 (m, 3H), 2.64, 2.59 (2s, 3H), 2.58 (s, 3H), 1.75-2.25 (m, 4H). MS (ESI) [M+H] + =480.2. 
     The compounds in Tables P1, P2, P3, P4, P5, P6, P7 and P8 were prepared as described in the examples above or similar methodology. 
     Table P1: Compounds of Formula (I-c) 
     
       
         
         
             
             
         
       
     
     The compounds in Table P1 can be prepared as described in the examples above or similar methodology. The following abbreviations are used in the table below: RT=retention time, min=minutes m.p.=melting point or melting range. 
     
       
         
           
               
               
               
               
               
               
               
             
               
                 TABLE P1 
               
               
                   
               
               
                 Comp. 
                   
                   
                   
                 LC-MS 
                   
                 m.p. 
               
               
                 No 
                 Y 
                 R 3   
                 [M + H] +   
                 RT (min) 
                 Method 
                 [° C.] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 P1.1 
                 5-methyl-1,2,4- 
                 CF 3   
                 509 
                 4.80 
                 1 
                 91-92 
               
               
                   
                 oxadiazole-3-yl 
               
               
                 P1.2 
                 CH 2 SCH 2 CH 3   
                 CF 3   
                 501 
                 5.47 
                 1 
                 118-120 
               
               
                 P1.3 
                 CH 2 S(═O)CH 2 CH 3   
                 CF 3   
                 517 
                 4.34 
                 1 
                 85-88 
               
               
                 P1.4 
                 CH 2 SO 2 CH 2 CH 3   
                 CF 3   
                 533 
                 4.63 
                 1 
                 87-89 
               
               
                 P1.5 
                 1,1-dioxo-1,2- 
                 CF 3   
                 546 
                 4.61 
                 1 
                 92-94 
               
               
                   
                 thiazolidin-2-yl 
               
               
                 P1.6 
                 5-methyl-1,2,4- 
                 CH 3   
                 455 
                 4.56 
                 1 
                 90-92 
               
               
                   
                 oxadiazole-3-yl 
               
               
                 P1.7 
                 CH 2 SCH 2 CH 3   
                 CH 3   
                 447 
                 5.24 
                 1 
                 95-97 
               
               
                 P1.8 
                 1,1-dioxo-1,2- 
                 CH 3   
                 492 
                 4.36 
                 1 
                 208-210 
               
               
                   
                 thiazolidin-2-yl 
               
               
                 P1.9 
                 5-methyl-1,2,4- 
                 H 
                 441 
                 4.45 
                 1 
               
               
                   
                 oxadiazole-3-yl 
               
               
                 P1.10 
                 CH 2 SCH 2 CH 3   
                 H 
                 433 
                 5.16 
                 1 
                 96-98 
               
               
                 P1.11 
                 1,1-dioxo-1,2- 
                 H 
                 478 
                 4.26 
                 1 
                 92-94 
               
               
                   
                 thiazolidin-2-yl 
               
               
                 P1.12 
                 CH 2 SCH 3   
                 CF 3   
                 487 
                 5.30 
                 1 
                 148-150 
               
               
                 P1.13 
                 CH 2 S(═O)CH 3   
                 CF 3   
                 503 
                 4.24 
                 1 
                  98-100 
               
               
                 P1.14 
                 CH 2 SO 2 CH 3   
                 CF 3   
                 519 
                 4.55 
                 1 
                 186-188 
               
               
                 P1.15 
                 CH 2 SCH 2 CH═CH 2   
                 CF 3   
                 513 
                 5.53 
                 1 
                 110-112 
               
               
                 P1.16 
                 CH 2 S(═O)CH 2 CH═CH 2   
                 CF 3   
                 529 
                 4.47 
                 1 
               
               
                 P1.17 
                 CH 2 SO 2 CH 2 CH═CH 2   
                 CF 3   
                 545 
                 4.75 
                 1 
                 96-98 
               
               
                 P1.18 
                 CH 2 SCH 2 CHCH 
                 CF 3   
                 511 
                 5.25 
                 1 
               
               
                 P1.19 
                 CH 2 S(═O)CH 2 CHCH 
                 CF 3   
                 527 
                 4.46 
                 1 
               
               
                 P1.20 
                 CH 2 SO 2 CH 2 CHCH 
                 CF 3   
                 543 
                 4.73 
                 1 
               
               
                 P1.21 
                 CH 2 SCH 2 CH 2 CH 3   
                 CF 3   
                 515 
                 5.68 
                 1 
                 112-114 
               
               
                 P1.22 
                 CH 2 S(═O)CH 2 CH 2 CH 3   
                 CF 3   
                 531 
                 4.54 
                 1 
                 91-93 
               
               
                 P1.23 
                 CH 2 SO 2 CH 2 CH 2 CH 3   
                 CF 3   
                 547 
                 4.63 
                 1 
                 93-95 
               
               
                 P1.24 
                 CH 2 SCH 3   
                 CH 3   
                 433 
                 5.11 
                 1 
                 120-122 
               
               
                 P1.25 
                 CH 2 S(═O)CH 3   
                 CH 3   
                 449 
                 3.99 
                 1 
                 167-169 
               
               
                 P1.26 
                 CH 2 SO 2 CH 3   
                 CH 3   
                 465 
                 5.11 
                 1 
                 161-163 
               
               
                 P1.27 
                 CH 2 SCH 2 CH═CH 2   
                 CH 3   
                 459 
                 5.37 
                 1 
                 100-102 
               
               
                 P1.28 
                 CH 2 S(═O)CH 2 CH═CH 2   
                 CH 3   
                 475 
                 4.25 
                 1 
               
               
                 P1.29 
                 CH 2 SO 2 CH 2 CH═CH 2   
                 CH 3   
                 491 
                 4.56 
                 1 
                 90-92 
               
               
                 P1.30 
                 CH 2 SCH 2 CHCH 
                 CH 3   
                 457 
                 5.10 
                 1 
               
               
                 P1.31 
                 CH 2 S(═O)CH 2 CHCH 
                 CH 3   
                 473 
                 4.25 
                 1 
                 63-65 
               
               
                 P1.32 
                 CH 2 SO 2 CH 2 CHCH 
                 CH 3   
                 489 
                 4.53 
                 1 
               
               
                 P1.33 
                 CH 2 SCH 2 CH 2 CH 3   
                 CH 3   
                 461 
                 5.56 
                 1 
                 118-120 
               
               
                 P1.34 
                 CH 2 S(═O)CH 2 CH 2 CH 3   
                 CH 3   
                 477 
                 4.26 
                 1 
               
               
                 P1.35 
                 CH 2 SO 2 CH 2 CH 2 CH 3   
                 CH 3   
                 493 
                 4.60 
                 1 
                  99-101 
               
               
                 P1.36 
                 (E)-N-methoxy-imino- 
                 CF 3   
                 484 
                 5.04 
                 1 
                 130-132 
               
               
                   
                 methyl 
               
               
                 P1.37 
                 (E)-N-ethoxy-imino- 
                 CF 3   
                 498 
                 5.22 
                 1 
                 115-117 
               
               
                   
                 methyl 
               
               
                 P1.38 
                 methylsulfonyl- 
                 CF 3   
                   
                   
                 1 
                 188-190 
               
               
                   
                 carbamoyl 
               
               
                 P1.39 
                 dimethylcarbamoyl 
                 CF 3   
                 498 
                 4.47 
                 1 
                 143-145 
               
               
                 P1.40 
                 ethyl(methyl)carbamoyl 
                 CF 3   
                   
                   
                 1 
               
               
                 P1.41 
                 methanesulfonamido 
                 CF 3   
                 520 
                 4.48 
                 1 
                 215-217 
               
               
                 P1.42 
                 ethanesulfonamido 
                 CF 3   
                 534 
                 4.60 
                 1 
                 224-226 
               
               
                 P1.43 
                 5-methyl-1,2,4- 
                 OCH 3   
                 471 
                 4.47 
                 1 
               
               
                   
                 oxadiazole-3-yl 
               
               
                 P1.44 
                 CH 2 SCH 2 CH 3   
                 OCH 3   
                 463 
                 5.14 
                 1 
                 162-164 
               
               
                 P1.45 
                 5-methyl-1,2,4- 
                 OCH 2 CH 3   
                 485 
                 4.66 
                 1 
               
               
                   
                 oxadiazole-3-yl 
               
               
                 P1.46 
                 CH 2 SCH 2 CH 3   
                 OCH 2 CH 3   
                 477 
                 5.32 
                 1 
                 68-70 
               
               
                 P1.47 
                 ethoxycarbonyl 
                 CF 3   
                 499 
                 5.09 
                 1 
               
               
                 P1.48 
                 tert-butoxy- 
                 CF 3   
                   
                 5.11 
                 1 
                 168-170 
               
               
                   
                 carbonylamino 
               
               
                 P1.49 
                 trifluoromethyl- 
                 CF 3   
                 538 
                 4.66 
                 1 
                 215-217 
               
               
                   
                 sulfonylamino 
               
               
                 P1.50 
                 1-methyl-1,2,4-triazol- 
                 CF 3   
                 508 
                 4.36 
                 1 
               
               
                   
                 3-yl 
               
               
                 P1.51 
                 phenyl 
                 CF 3   
                 503 
                 5.51 
                 1 
                 154-156 
               
               
                 P1.52 
                 ethoxymethyl 
                 CF 3   
                 485 
                 5.23 
                 1 
                 110-112 
               
               
                 P1.53 
                 cyano 
                 CF 3   
                 452 
                 5.25 
                 1 
                 102-104 
               
               
                   
               
            
           
         
       
     
     Table P2: Compounds of Formula (I-d) 
     
       
         
         
             
             
         
       
     
     The compounds in Table P2 can be prepared as described in the examples above or similar methodology. The following abbreviations are used in the table below: RT=retention time, min=minutes, m.p.=melting point. 
     
       
         
           
               
               
               
               
               
               
               
             
               
                 TABLE P2 
               
               
                   
               
               
                 Comp. 
                   
                   
                   
                 LC-MS 
                   
                 m.p. 
               
               
                 No 
                 A 
                 R 3   
                 [M + H] +   
                 RT (min) 
                 Method 
                 [° C.] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 P2.1 
                 3,5-dichloro-2-pyridyl 
                 CF 3   
                 573 
                 5.69 
                 1 
                 79-80 
               
               
                 P2.2 
                 3,5-dichloro-2-pyridyl 
                 CH 3   
                 519 
                 5.55 
                 1 
                 135-137 
               
               
                 P2.3 
                 3,5-dichloro-2-pyridyl 
                 H 
                 505 
                 5.43 
                 1 
                 160-162 
               
               
                 P2.4 
                 3,5-dichloro-2-pyridyl 
                 OCH 3   
                 536 
                 5.45 
                 1 
                 222-224 
               
               
                 P2.5 
                 3,5-dichloro-2-pyridyl 
                 OCH 2 CH 3   
                 549 
                 5.63 
                 1 
                 97-99 
               
               
                 P2.6 
                 cyano 
                 CF 3   
                 453 
                 1.03 
                 2 
                 152-155 
               
               
                 P2.7 
                 CH 2 CN 
                 CF 3   
                 467 
                 4.63 
                 2 
                 138-140 
               
               
                 P2.8 
                 CH 2 CH 2 CN 
                 CF 3   
                 481 
                 4.27 
                 1 
                 140-142 
               
               
                 P2.9 
                 2,2,2-trifluoroethyl 
                 CF 3   
                 510 
                 1.17 
                 2 
                 142-144 
               
               
                 P2.10 
                 3,3-dichloroallyl 
                 CF 3   
                 536 
                 4.52 
                 1 
                 148-150 
               
               
                 P2.11 
                 CH 2 CH 2 SCH 3   
                 CF 3   
                 502 
                 3.95 
                 1 
                 114-116 
               
               
                 P2.12 
                 CH 2 CH 2 S(═O)CH 3   
                 CF 3   
                 518 
                 3.71 
                 1 
                 94-96 
               
               
                 P2.13 
                 methylsulfonyl 
                 CF 3   
                 506 
                 4.64 
                 1 
                 200-202 
               
               
                 P2.14 
                 trifluoromethyl- 
                 CF 3   
                 560 
                 5.21 
                 1 
                 217-219 
               
               
                   
                 sulfonyl 
               
               
                 P2.15 
                 tert-butoxy-carbonyl 
                 CF 3   
                 n/a 
                 1.19 
                 2 
                 159-161 
               
               
                 P2.16 
                 trifluoromethyl- 
                 CF 3   
                 524 
                 4.97 
                 1 
                 193-195 
               
               
                   
                 carbonyl 
               
               
                 P2.17 
                 methoxyethyl 
                 CF 3   
                 486 
                 3.81 
                 1 
               
               
                   
               
            
           
         
       
     
     Table P: Compounds of Formula (I-e) 
     
       
         
         
             
             
         
       
     
     The compounds in Table P3 can be prepared as described in the examples above or similar methodology. The following abbreviations are used in the table below: RT=retention time, min=minutes; m.p.=melting point. 
     
       
         
           
               
               
               
               
               
               
               
             
               
                 TABLE P3 
               
               
                   
               
               
                 Comp. 
                   
                   
                   
                 LC-MS 
                   
                 m.p. 
               
               
                 No 
                 Y 
                 R 3   
                 [M + H] +   
                 RT (min) 
                 Method 
                 [° C.] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 P3.1 
                 CH 2 SCH 3   
                 CF 3   
                 459 
                 5.01 
                 1 
                 120-122 
               
               
                 P3.2 
                 CH 2 S(═O)CH 3   
                 CF 3   
                 475 
                 4.07 
                 1 
                 142-144 
               
               
                 P3.3 
                 CH 2 SO 2 CH 3   
                 CF 3   
                 491 
                 4.39 
                 1 
                 167-169 
               
               
                 P3.4 
                 CH 2 SCH 2 CH 3   
                 CF 3   
                 473 
                 5.78 
                 1 
                 97-99 
               
               
                 P3.5 
                 CH 2 S(═O)CH 2 CH 3   
                 CF 3   
                 489 
                 4.20 
                 1 
                 75-77 
               
               
                 P3.6 
                 CH 2 SO 2 CH 2 CH 3   
                 CF 3   
                 505 
                 4.50 
                 1 
                 150-152 
               
               
                 P3.7 
                 CH 2 S(═O)CH 2 CH 2 CH 3   
                 CF 3   
                 503 
                 4.36 
                 1 
               
               
                 P3.8 
                 CH 2 SO 2 CH 2 CH 2 CH 3   
                 CF 3   
                 519 
                 4.66 
                 1 
                 80-82 
               
               
                 P3.9 
                 CH 2 SCH 2 CH 2 CH 3   
                 CF 3   
                 487 
                 5.38 
                 1 
               
               
                   
               
            
           
         
       
     
     Table P4: Compounds of Formula (I-e) 
     
       
         
         
             
             
         
       
     
     The compounds in Table P2 can be prepared as described in the examples above or similar methodology. The following abbreviations are used in the table below: RT=retention time, min=minutes, m.p.=melting point. 
     
       
         
           
               
               
               
               
               
               
               
             
               
                 TABLE P4 
               
               
                   
               
               
                 Comp. 
                   
                   
                   
                 LC-MS 
                   
                 m.p. 
               
               
                 No 
                 R m   
                 R 3   
                 [M + H] +   
                 RT (min) 
                 Method 
                 [° C.] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 P4.1 
                 methyl 
                 CF 3   
                 470 
                 4.93 
                 1 
                 136-138 
               
               
                 P4.2 
                 ethyl 
                 CF 3   
                 484 
                 5.11 
                 1 
                 118-120 
               
               
                   
               
            
           
         
       
     
     Table P5: Compounds of Formula (I-q) 
     
       
         
         
             
             
         
       
     
     The compound in Table P5 can be prepared as described in the examples above or similar methodology. The following abbreviations are used in the table below: RT=retention time, min=minutes; m.p.=melting point. 
     
       
         
           
               
               
               
               
               
               
               
               
             
               
                 TABLE P5 
               
               
                   
               
               
                 Comp. 
                   
                   
                   
                   
                 LC-MS 
                   
                 m.p. 
               
               
                 No 
                 Y 
                 X 
                 R 3   
                 [M + H] +   
                 RT (min) 
                 Method 
                 [° C.] 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 P5.1 
                 phenyl 
                 OH 
                 CF 3   
                 519 
                 4.4 
                 1 
                 221-223 
               
               
                 P5.2 
                 4-Cl-phenyl 
                 OH 
                 CF 3   
                 553 
                 5.2 
                 1 
                 250-251 
               
               
                 P5.3 
                 4-Cl-phenyl 
                 OCH 3   
                 CF 3   
                 567 
                 1.29 
                 2 
                 103-105 
               
               
                   
               
            
           
         
       
     
     Table P6: Compounds of Formula (I-h) 
     
       
         
         
             
             
         
       
     
     The compound in Table P6 can be prepared as described in the examples above or similar methodology. The following abbreviations are used in the table below: RT=retention time, min=minutes; m.p.=melting point. 
     
       
         
           
               
               
               
               
               
               
               
             
               
                 TABLE P6 
               
               
                   
               
               
                 Comp. 
                   
                   
                   
                 LC-MS 
                   
                 m.p. 
               
               
                 No 
                 Y 
                 R 3   
                 [M + H] +   
                 RT (min) 
                 Method 
                 [° C.] 
               
               
                   
               
             
            
               
                 P6.1 
                 5-methyl-1,2,4- 
                 CH 3   
                 480 
                 4.46 
                 1 
                 118-120 
               
               
                   
                 oxadiazole-3-yl 
               
               
                   
               
            
           
         
       
     
     Table P7: Compounds of Formula (I-i) 
     
       
         
         
             
             
         
       
     
     The compound in Table P7 can be prepared as described in the examples above or similar methodology. The following abbreviations are used in the table below: RT=retention time, min=minutes; m.p.=melting point. 
     
       
         
           
               
               
               
               
               
               
               
             
               
                 TABLE P7 
               
               
                   
               
               
                 Comp. 
                   
                   
                   
                 LC-MS 
                   
                 m.p. 
               
               
                 No 
                 A 
                 R 3   
                 [M + H] +   
                 RT (min) 
                 Method 
                 [° C.] 
               
               
                   
               
             
            
               
                 P7.1 
                 3,5-dichloro- 
                 CH 3   
                 544 
                 5.31 
                 1 
                 185-187 
               
               
                   
                 2-pyridyl 
               
               
                   
               
            
           
         
       
     
     Table P8: Compounds of Formula (I-j) 
     
       
         
         
             
             
         
       
     
     The compound in Table P8 can be prepared as described in the examples above or similar methodology. The following abbreviations are used in the table below: RT=retention time, min=minutes; m.p.=melting point. 
     
       
         
           
               
               
               
               
               
               
               
             
               
                 TABLE P8 
               
               
                   
               
               
                 Comp. 
                   
                   
                   
                 LC-MS 
                   
                 m.p. 
               
               
                 No 
                 A 
                 R 3   
                 [M + H] +   
                 RT (min) 
                 Method 
                 [° C.] 
               
               
                   
               
             
            
               
                 P8.1 
                 3,5-dichloro- 
                 CF 3   
                 607 
                 1.25 
                 2 
                   
               
               
                   
                 2-pyridyl 
               
               
                   
               
            
           
         
       
     
     The intermediates in Table U1 are new and useful for the synthesis of some compounds of the general structure I. They can be prepared as described in the examples above or similar methodology. The following abbreviations are used in the table below: s=singlet, d=doublet, t=triplet, q=quartet, m=multiplet. 
     
       
         
           
               
               
               
             
               
                 TABLE U1 
               
               
                   
               
               
                 Comp. No 
                 Structure 
                   1 H-NMR: δ in [ppm] 
               
               
                   
               
             
            
               
                 U1.1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 In DMSO-d6: 8.53 (s, 1H), 8.17 (s, 1H), 7.9-8.1 (m, 4H), 3.93 (s, 3H). 
               
               
                   
               
               
                 U1.2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 In DMSO-d6: 8.46 (s, 1H), 8.11 (s, 1H), 7.8-8.0 (m, 4H). 
               
               
                   
               
               
                 U1.3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 In DMSO-d6: 8.33 (s, 1H) , 7.94 (d, 2H), 7.86 (d, 2H), 7.71 (s, 1H), 3.33 (s, 3H), 2.65 (s, 3H). 
               
               
                   
               
               
                 U1.4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 In DMSO-d6: 8.31 (s, 1H), 7.94 (d, 2H), 7.86 (d, 2H), 7.78 (s, 1H), 2.66 (s, 3H). 
               
               
                   
               
               
                 U1.5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 In DMSO-d6: 8.20 (s, 1H), 7.95 (d, 2H), 7.89 (d, 2H), 7.40 (s, 1H), 4.30 (q, 2H), 3.99 (s, 3H), 1.30 (dd, 3H). 
               
               
                   
               
               
                 U1.6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 In CDCl 3 : 8.58 (s, 1H), 7.81 (d, 2H), 7.70 (d, 2H), 7.14 (s, 1H), 4.18 (s, 3H).  
               
               
                   
               
               
                 U1.7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 In CDCl 3 : 8.22 (s, 1H), 7.77 (d, 2H), 7.68 (d, 2H), 7.01 (s, 1H), 4.40 (q, 2H), 4.22 (q, 2H), 1.52 (t, 3H), 1.41 (t, 3H).  
               
               
                   
               
               
                 U1.8 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 In DMSO-d6: 8.44 (s, 1H), 8.30 (d, 1H), 7.93 (d, 2H), 7.79-7.90 (m, 3H), 3.91 (s, 3H).  
               
               
                   
               
               
                 U1.9 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 In CDCl 3 : 8.45 (s, 1H), 7.84 (d, 2H), 7.64 (d, 2H), 4.46 (q, 2H), 2.97 (s, 3H), 1.45 (t, 3H).  
               
               
                   
               
               
                 U1.10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 In DMSO-d6: 8.57 (s, 1H), 8.02 (d, 2H), 7.87 (d, 2H), 2.83 (s, 3H). 
               
               
                   
               
            
           
         
       
     
     The activity of the compositions according to the invention can be broadened considerably, and adapted to prevailing circumstances, by adding other insecticidally, acaricidally and/or fungicidally active ingredients. The mixtures of the compounds of formula (I) with other insecticidally, acaricidally and/or fungicidally active ingredients may also have further surprising advantages which can also be described, in a wider sense, as synergistic activity. For example, better tolerance by plants, reduced phytotoxicity, insects can be controlled in their different development stages or better behaviour during their production, for example during grinding or mixing, during their storage or during their use. 
     Suitable additions to active ingredients here are, for example, representatives of the following classes of active ingredients: organophosphorus compounds, nitrophenol derivatives, thioureas, juvenile hormones, formamidines, benzophenone derivatives, ureas, pyrrole derivatives, carbamates, pyrethroids, chlorinated hydrocarbons, acylureas, pyridylmethyleneamino derivatives, macrolides, neonicotinoids and  Bacillus thuringiensis  preparations. 
     The following mixtures of a compound of formula (I) with an active substances are preferred (the abbreviation “TX” means “one compound selected from the compounds defined in Tables 1 to 35 and Tables P1 to P8): 
     an adjuvant selected from the group of substances consisting of petroleum oils (alternative name) (628)+TX, 
     an insect control active substance selected from Abamectin+TX, Acequinocyl+TX, Acetamiprid+TX, Acetoprole+TX, Acrinathrin+TX, Acynonapyr+TX, Afidopyropen+TX, Afoxolaner+TX, Alanycarb+TX, Allethrin+TX, Alpha-Cypermethrin+TX, Alphamethrin+TX, Amidoflumet+TX, Aminocarb+TX, Azocyclotin+TX, Bensultap+TX, Benzoximate+TX, Benzpyrimoxan+TX, Betacyfluthrin+TX, Beta-cypermethrin+TX, Bifenazate+TX, Bifenthrin+TX, Binapacryl+TX, Bioallethrin+TX, Bioallethrin S)-cyclopentylisomer+TX, Bioresmethrin+TX, Bistrifluron+TX, Broflanilide+TX, Brofluthrinate+TX, Bromophos-ethyl+TX, Buprofezine+TX, Butocarboxim+TX, Cadusafos+TX, Carbaryl+TX, Carbosulfan+TX, Cartap+TX, CAS number: 1632218-00-8+TX, CAS number: 1808115-49-2+TX, CAS number: 2032403-97-5+TX, CAS number: 2044701-44-0+TX, CAS number: 2128706-05-6+TX, CAS number: 2246757-58-2 (or 2249718-27-0)+TX, CAS number: 907187-07-9+TX, Chlorantraniliprole+TX, Chlordane+TX, Chlorfenapyr+TX, Chloroprallethrin+TX, Chromafenozide+TX, Clenpirin+TX, Cloethocarb+TX, Clothianidin+TX, 2-chlorophenyl N-methylcarbamate (CPMC)+TX, Cyanofenphos+TX, Cyantraniliprole+TX, Cyclaniliprole+TX, Cyclobutrifluram+TX, Cycloprothrin+TX, Cycloxaprid+TX, Cycloxaprid+TX, Cyenopyrafen+TX, Cyetpyrafen+TX, Cyflumetofen+TX, Cyfluthrin+TX, Cyhalodiamide+TX, Cyhalothrin+TX, Cypermethrin+TX, Cyphenothrin+TX, Cyproflanilide+TX, Cyromazine+TX, Deltamethrin+TX, Diafenthiuron+TX, Dialifos+TX, Dibrom+TX, Dicloromezotiaz+TX, Diflovidazine+TX, Diflubenzuron+TX, dimpropyridaz+TX, Dinactin+TX, Dinocap+TX, Dinotefuran+TX, Dioxabenzofos+TX, Emamectin (or Emamectin Benzoate)+TX, Empenthrin+TX, Epsilon-momfluorothrin+TX, Epsilon-metofluthrin+TX, Esfenvalerate+TX, Ethion+TX, Ethiprole+TX, Etofenprox+TX, Etoxazole+TX, Famphur+TX, Fenazaquin+TX, Fenfluthrin+TX, Fenitrothion+TX, Fenobucarb+TX, Fenothiocarb+TX, Fenoxycarb+TX, Fenpropathrin+TX, Fenpyroxymate+TX, Fensulfothion+TX, Fenthion+TX, Fentinacetate+TX, Fenvalerate+TX, Fipronil+TX, Flometoquin+TX, Flonicamid+TX, Fluacrypyrim+TX, Fluazaindolizine+TX, Fluazuron+TX, Flubendiamide+TX, Flubenzimine+TX, Flucitrinate+TX, Flucycloxuron+TX, Flucythrinate+TX, Fluensulfone+TX, Flufenerim+TX, Flufenprox+TX, Flufiprole+TX, Fluhexafon+TX, Flumethrin+TX, Fluopyram+TX, Flupentiofenox+TX, Flupyradifurone+TX, Flupyrimin+TX, Fluralaner+TX, Fluvalinate+TX, Fluxametamide+TX, Fosthiazate+TX, Gamma-Cyhalothrin+TX, Gossyplure™+TX, Guadipyr+TX, Halofenozide+TX, Halofenozide+TX, Halfenprox+TX, Heptafluthrin+TX, Hexythiazox+TX, Hydramethylnon+TX, Imicyafos+TX, Imidacloprid+TX, Imiprothrin+TX, Indoxacarb+TX, Iodomethane+TX, Iprodione+TX, Isocycloseram+TX, Isothioate+TX, Ivermectin+TX, Kappa-bifenthrin+TX, Kappa-tefluthrin+TX, Lambda-Cyhalothrin+TX, Lepimectin+TX, Lufenuron+TX, Metaflumizone+TX, Metaldehyde+TX, Metam+TX, Methomyl+TX, Methoxyfenozide+TX, Metofluthrin+TX, Metolcarb+TX, Mexacarbate+TX, Milbemectin+TX, Momfluorothrin+TX, Niclosamide+TX, Nicofluprole+TX; Nitenpyram+TX, Nithiazine+TX, Omethoate+TX, Oxamyl+TX, Oxazosulfyl+TX, Parathion-ethyl+TX, Permethrin+TX, Phenothrin+TX, Phosphocarb+TX, Piperonylbutoxide+TX, Pirimicarb+TX, Pirimiphos-ethyl+TX, Pirimiphos-methyl+TX, Polyhedrosis virus+TX, Prallethrin+TX, Profenofos+TX, Profenofos+TX, Profluthrin+TX, Propargite+TX, Propetamphos+TX, Propoxur+TX, Prothiophos+TX, Protrifenbute+TX, Pyflubumide+TX, Pymetrozine+TX, Pyraclofos+TX, Pyrafluprole+TX, Pyridaben+TX, Pyridalyl+TX, Pyrifluquinazon+TX, Pyrimidifen+TX, Pyriminostrobin+TX, Pyriprole+TX, Pyriproxyfen+TX, Resmethrin+TX, Sarolaner+TX, Selamectin+TX, Silafluofen+TX, Spinetoram+TX, Spinosad+TX, Spirodiclofen+TX, Spiromesifen+TX, Spiropidion+TX, Spirotetramat+TX, Sulfoxaflor+TX, Tebufenozide+TX, Tebufenpyrad+TX, Tebupirimiphos+TX, Tefluthrin+TX, Temephos+TX, Tetrachlorantraniliprole+TX, Tetradiphon+TX, Tetramethrin+TX, Tetramethylfluthrin+TX, Tetranactin+TX, Tetraniliprole+TX, Theta-cypermethrin+TX, Thiacloprid+TX, Thiamethoxam+TX, Thiocyclam+TX, Thiodicarb+TX, Thiofanox+TX, Thiometon+TX, Thiosultap+TX, Tioxazafen+TX, Tolfenpyrad+TX, Toxaphene+TX, Tralomethrin+TX, Transfluthrin+TX, Triazamate+TX, Triazophos+TX, Trichlorfon+TX, Trichloronate+TX, Trichlorphon+TX, Triflumezopyrim+TX, Tyclopyrazoflor+TX, Zeta-Cypermethrin+TX, Extract of seaweed and fermentation product derived from melasse+TX, Extract of seaweed and fermentation product derived from melasse comprising urea+TX, amino acids+TX, potassium and molybdenum and EDTA-chelated manganese+TX, Extract of seaweed and fermented plant products+TX, Extract of seaweed and fermented plant products comprising phytohormones+TX, vitamins+TX, EDTA-chelated copper+TX, zinc+TX and iron+TX, Azadirachtin+TX,  Bacillus aizawai +TX,  Bacillus chitinosporus  AQ746 (NRRL Accession No B-21 618)+TX,  Bacillus firmus +TX,  Bacillus kurstaki +TX,  Bacillus mycoides  AQ726 (NRRL Accession No. B-21664)+TX,  Bacillus pumilus  (NRRL Accession No B-30087)+TX,  Bacillus pumilus  AQ717 (NRRL Accession No. B-21662)+TX,  Bacillus  sp. AQ178 (ATCC Accession No. 53522)+TX,  Bacillus  sp. AQ175 (ATCC Accession No. 55608)+TX,  Bacillus  sp. AQ177 (ATCC Accession No. 55609)+TX,  Bacillus subtilis  unspecified+TX,  Bacillus subtilis  AQ153 (ATCC Accession No. 55614)+TX,  Bacillus subtilis  AQ30002 (NRRL Accession No. B-50421)+TX,  Bacillus subtilis  AQ30004 (NRRL Accession No. B-50455)+TX,  Bacillus subtilis  AQ713 (NRRL Accession No. B-21661)+TX,  Bacillus subtilis  AQ743 (NRRL Accession No. B-21665)+TX,  Bacillus thuringiensis  AQ52 (NRRL Accession No. B-21619)+TX,  Bacillus thuringiensis  BD #32 (NRRL Accession No B-21530)+TX,  Bacillus thuringiensis  subspec.  kurstaki  BMP 123+TX,  Beauveria bassiana +TX, D-limonene+TX,  Granulovirus +TX, Harpin+TX,  Helicoverpa armigera  Nucleopolyhedrovirus+TX,  Helicoverpa zea  Nucleopolyhedrovirus+TX,  Heliothis virescens  Nucleopolyhedrovirus+TX,  Heliothis punctigera  Nucleopolyhedrovirus+TX,  Metarhizium  spp.+TX,  Muscodor albus  620 (NRRL Accession No. 30547)+TX,  Muscodor roseus  A3-5 (NRRL Accession No. 30548)+TX, Neem tree based products+TX,  Paecilomyces fumosoroseus +TX,  Paecilomyces lilacinus +TX,  Pasteuria nishizawae +TX,  Pasteuria penetrans +TX,  Pasteuria ramosa +TX,  Pasteuria thornei +TX,  Pasteuria usgae +TX, P-cymene+TX,  Plutella xylostella  Granulosis virus+TX,  Plutella xylostella  Nucleopolyhedrovirus+TX, Polyhedrosis virus+TX,  pyrethrum +TX, QRD 420 (a terpenoid blend)+TX, QRD 452 (a terpenoid blend)+TX, QRD 460 (a terpenoid blend)+TX,  Quillaja saponaria +TX,  Rhodococcus globerulus  AQ719 (NRRL Accession No B-21663)+TX,  Spodoptera frugiperda  Nucleopolyhedrovirus+TX,  Streptomyces galbus  (NRRL Accession No. 30232)+TX,  Streptomyces  sp. (NRRL Accession No. B-30145)+TX, Terpenoid blend+TX and  Verticillium  spp.; 
     an algicide selected from the group of substances consisting of bethoxazin [CCN]+TX, copper dioctanoate (IUPAC name) (170)+TX, copper sulfate (172)+TX, cybutryne [CCN]+TX, dichlone (1052)+TX, dichlorophen (232)+TX, endothal (295)+TX, fentin (347)+TX, hydrated lime [CCN]+TX, nabam (566)+TX, quinoclamine (714)+TX, quinonamid (1379)+TX, simazine (730)+TX, triphenyltin acetate (IUPAC name) (347) and triphenyltin hydroxide (IUPAC name) (347)+TX; 
     an anthelmintic selected from the group of substances consisting of abamectin (1)+TX, crufomate (1011)+TX, Cyclobutrifluram+TX, doramectin (alternative name) [CCN]+TX, emamectin (291)+TX, emamectin benzoate (291)+TX, eprinomectin (alternative name) [CCN]+TX, ivermectin (alternative name) [CCN]+TX, milbemycin oxime (alternative name) [CCN]+TX, moxidectin (alternative name) [CCN]+TX, piperazine [CCN]+TX, selamectin (alternative name) [CCN]+TX, spinosad (737) and thiophanate (1435)+TX; 
     an avicide selected from the group of substances consisting of chloralose (127)+TX, endrin (1122)+TX, fenthion (346)+TX, pyridin-4-amine (IUPAC name) (23) and strychnine (745)+TX; a bactericide selected from the group of substances consisting of 1-hydroxy-1H-pyridine-2-thione (IUPAC name) (1222)+TX, 4-(quinoxalin-2-ylamino)benzenesulfonamide (IUPAC name) (748)+TX, 8-hydroxyquinoline sulfate (446)+TX, bronopol (97)+TX, copper dioctanoate (IUPAC name) (170)+TX, copper hydroxide (IUPAC name) (169)+TX, cresol [CCN]+TX, dichlorophen (232)+TX, dipyrithione (1105)+TX, dodicin (1112)+TX, fenaminosulf (1144)+TX, formaldehyde (404)+TX, hydrargaphen (alternative name) [CCN]+TX, kasugamycin (483)+TX, kasugamycin hydrochloride hydrate (483)+TX, nickel bis(dimethyldithiocarbamate) (IUPAC name) (1308)+TX, nitrapyrin (580)+TX, octhilinone (590)+TX, oxolinic acid (606)+TX, oxytetracycline (611)+TX, potassium hydroxyquinoline sulfate (446)+TX, probenazole (658)+TX, streptomycin (744)+TX, streptomycin sesquisulfate (744)+TX, tecloftalam (766)+TX, and thiomersal (alternative name) [CCN]+TX; 
     a biological agent selected from the group of substances consisting of  Adoxophyes orana  GV (alternative name) (12)+TX,  Agrobacterium radiobacter  (alternative name) (13)+TX,  Amblyseius  spp. (alternative name) (19)+TX,  Anagrapha falcifera  NPV (alternative name) (28)+TX,  Anagrus atomus  (alternative name) (29)+TX,  Aphelinus abdominalis  (alternative name) (33)+TX,  Aphidius colemani  (alternative name) (34)+TX,  Aphidoletes aphidimyza  (alternative name) (35)+TX,  Autographa californica  NPV (alternative name) (38)+TX,  Bacillus firmus  (alternative name) (48)+TX,  Bacillus sphaericus  Neide (scientific name) (49)+TX,  Bacillus thuringiensis  Berliner (scientific name) (51)+TX,  Bacillus thuringiensis  subsp.  aizawai  (scientific name) (51)+TX,  Bacillus thuringiensis  subsp.  israelensis  (scientific name) (51)+TX,  Bacillus thuringiensis  subsp.  japonensis  (scientific name) (51)+TX,  Bacillus thuringiensis  subsp.  kurstaki  (scientific name) (51)+TX,  Bacillus thuringiensis  subsp.  tenebrionis  (scientific name) (51)+TX,  Beauveria bassiana  (alternative name) (53)+TX,  Beauveria brongniartii  (alternative name) (54)+TX,  Chrysoperla carnea  (alternative name) (151)+TX,  Cryptolaemus montrouzieri  (alternative name) (178)+TX,  Cydia pomonella  GV (alternative name) (191)+TX,  Dacnusa sibirica  (alternative name) (212)+TX,  Diglyphus isaea  (alternative name) (254)+TX,  Encarsia formosa  (scientific name) (293)+TX,  Eretmocerus eremicus  (alternative name) (300)+TX,  Helicoverpa zea  NPV (alternative name) (431)+TX,  Heterorhabditis bacteriophora  and  H. megidis  (alternative name) (433)+TX,  Hippodamia convergens  (alternative name) (442)+TX,  Leptomastix dactylopii  (alternative name) (488)+TX,  Macrolophus caliginosus  (alternative name) (491)+TX,  Mamestra brassicae  NPV (alternative name) (494)+TX,  Metaphycus helvolus  (alternative name) (522)+TX,  Metarhizium anisopliae  var.  acridum  (scientific name) (523)+TX,  Metarhizium anisopliae  var.  anisopliae  (scientific name) (523)+TX,  Neodiprion sertifer  NPV and  N. lecontei  NPV (alternative name) (575)+TX,  Orius  spp. (alternative name) (596)+TX,  Paecilomyces fumosoroseus  (alternative name) (613)+TX,  Phytoseiulus persimilis  (alternative name) (644)+TX,  Spodoptera exigua  multicapsid nuclear polyhedrosis virus (scientific name) (741)+TX,  Steinernema bibionis  (alternative name) (742)+TX,  Steinernema carpocapsae  (alternative name) (742)+TX,  Steinernema feltiae  (alternative name) (742)+TX,  Steinernema glaseri  (alternative name) (742)+TX,  Steinernema riobrave  (alternative name) (742)+TX,  Steinernema riobravis  (alternative name) (742)+TX,  Steinernema scapterisci  (alternative name) (742)+TX,  Steinernema  spp. (alternative name) (742)+TX,  Trichogramma  spp. (alternative name) (826)+TX,  Typhlodromus occidentalis  (alternative name) (844) and  Verticillium lecanii  (alternative name) (848)+TX; 
     a soil sterilant selected from the group of substances consisting of iodomethane (IUPAC name) (542) and methyl bromide (537)+TX; 
     a chemosterilant selected from the group of substances consisting of apholate [CCN]+TX, bisazir (alternative name) [CCN]+TX, busulfan (alternative name) [CCN]+TX, diflubenzuron (250)+TX, dimatif (alternative name) [CCN]+TX, hemel [CCN]+TX, hempa [CCN]+TX, metepa [CCN]+TX, methiotepa [CCN]+TX, methyl apholate [CCN]+TX, morzid [CCN]+TX, penfluron (alternative name) [CCN]+TX, tepa [CCN]+TX, thiohempa (alternative name) [CCN]+TX, thiotepa (alternative name) [CCN]+TX, tretamine (alternative name) [CCN] and uredepa (alternative name) [CCN]+TX; 
     an insect pheromone selected from the group of substances consisting of (E)-dec-5-en-1-yl acetate with (E)-dec-5-en-1-ol (IUPAC name) (222)+TX, (E)-tridec-4-en-1-yl acetate (IUPAC name) (829)+TX, (E)-6-methylhept-2-en-4-ol (IUPAC name) (541)+TX, (E,Z)-tetradeca-4,10-dien-1-yl acetate (IUPAC name) (779)+TX, (Z)-dodec-7-en-1-yl acetate (IUPAC name) (285)+TX, (Z)-hexadec-11-enal (IUPAC name) (436)+TX, (Z)-hexadec-11-en-1-yl acetate (IUPAC name) (437)+TX, (Z)-hexadec-13-en-11-yn-1-yl acetate (IUPAC name) (438)+TX, (Z)-icos-13-en-10-one (IUPAC name) (448)+TX, (Z)-tetradec-7-en-1-al (IUPAC name) (782)+TX, (Z)-tetradec-9-en-1-ol (IUPAC name) (783)+TX, (Z)-tetradec-9-en-1-yl acetate (IUPAC name) (784)+TX, (7E,9Z)-dodeca-7,9-dien-1-yl acetate (IUPAC name) (283)+TX, (9Z,11E)-tetradeca-9,11-dien-1-yl acetate (IUPAC name) (780)+TX, (9Z,12E)-tetradeca-9,12-dien-1-yl acetate (IUPAC name) (781)+TX, 14-methyloctadec-1-ene (IUPAC name) (545)+TX, 4-methylnonan-5-ol with 4-methylnonan-5-one (IUPAC name) (544)+TX, alpha-multistriatin (alternative name) [CCN]+TX, brevicomin (alternative name) [CCN]+TX, codlelure (alternative name) [CCN]+TX, codlemone (alternative name) (167)+TX, cuelure (alternative name) (179)+TX, disparlure (277)+TX, dodec-8-en-1-yl acetate (IUPAC name) (286)+TX, dodec-9-en-1-yl acetate (IUPAC name) (287)+TX, dodeca-8+TX, 10-dien-1-yl acetate (IUPAC name) (284)+TX, dominicalure (alternative name) [CCN]+TX, ethyl 4-methyloctanoate (IUPAC name) (317)+TX, eugenol (alternative name) [CCN]+TX, frontalin (alternative name) [CCN]+TX, gossyplure (alternative name) (420)+TX, grandlure (421)+TX, grandlure I (alternative name) (421)+TX, grandlure II (alternative name) (421)+TX, grandlure III (alternative name) (421)+TX, grandlure IV (alternative name) (421)+TX, hexalure [CCN]+TX, ipsdienol (alternative name) [CCN]+TX, ipsenol (alternative name) [CCN]+TX, japonilure (alternative name) (481)+TX, lineatin (alternative name) [CCN]+TX, litlure (alternative name) [CCN]+TX, looplure (alternative name) [CCN]+TX, medlure [CCN]+TX, megatomoic acid (alternative name) [CCN]+TX, methyl eugenol (alternative name) (540)+TX, muscalure (563)+TX, octadeca-2,13-dien-1-yl acetate (IUPAC name) (588)+TX, octadeca-3,13-dien-1-yl acetate (IUPAC name) (589)+TX, orfralure (alternative name) [CCN]+TX, oryctalure (alternative name) (317)+TX, ostramone (alternative name) [CCN]+TX, siglure [CCN]+TX, sordidin (alternative name) (736)+TX, sulcatol (alternative name) [CCN]+TX, tetradec-11-en-1-yl acetate (IUPAC name) (785)+TX, trimedlure (839)+TX, trimedlure A (alternative name) (839)+TX, trimedlure B 1  (alternative name) (839)+TX, trimedlure B 2  (alternative name) (839)+TX, trimedlure C (alternative name) (839) and trunc-call (alternative name) [CCN]+TX; 
     an insect repellent selected from the group of substances consisting of 2-(octylthio)ethanol (IUPAC name) (591)+TX, butopyronoxyl (933)+TX, butoxy(polypropylene glycol) (936)+TX, dibutyl adipate (IUPAC name) (1046)+TX, dibutyl phthalate (1047)+TX, dibutyl succinate (IUPAC name) (1048)+TX, diethyltoluamide [CCN]+TX, dimethyl carbate [CCN]+TX, dimethyl phthalate [CCN]+TX, ethyl hexanediol (1137)+TX, hexamide [CCN]+TX, methoquin-butyl (1276)+TX, methylneodecanamide [CCN]+TX, oxamate [CCN] and picaridin [CCN]+TX; a molluscicide selected from the group of substances consisting of bis(tributyltin) oxide (IUPAC name) (913)+TX, bromoacetamide [CCN]+TX, calcium arsenate [CCN]+TX, cloethocarb (999)+TX, copper acetoarsenite [CCN]+TX, copper sulfate (172)+TX, fentin (347)+TX, ferric phosphate (IUPAC name) (352)+TX, metaldehyde (518)+TX, methiocarb (530)+TX, niclosamide (576)+TX, niclosamide-olamine (576)+TX, pentachlorophenol (623)+TX, sodium pentachlorophenoxide (623)+TX, tazimcarb (1412)+TX, thiodicarb (799)+TX, tributyltin oxide (913)+TX, trifenmorph (1454)+TX, trimethacarb (840)+TX, triphenyltin acetate (IUPAC name) (347) and triphenyltin hydroxide (IUPAC name) (347)+TX, pyriprole [394730-71-3] + TX; 
     a nematicide selected from the group of substances consisting of AKD-3088 (compound code)+TX, 1,2-dibromo-3-chloropropane (IUPAC/Chemical Abstracts name) (1045)+TX, 1,2-dichloropropane (IUPAC/Chemical Abstracts name) (1062)+TX, 1,2-dichloropropane with 1,3-dichloropropene (IUPAC name) (1063)+TX, 1,3-dichloropropene (233)+TX, 3,4-dichlorotetrahydrothiophene 1,1-dioxide (IUPAC/Chemical Abstracts name) (1065)+TX, 3-(4-chlorophenyl)-5-methylrhodanine (IUPAC name) (980)+TX, 5-methyl-6-thioxo-1,3,5-thiadiazinan-3-ylacetic acid (IUPAC name) (1286)+TX, 6-isopentenylaminopurine (alternative name) (210)+TX, abamectin (1)+TX, acetoprole [CCN]+TX, alanycarb (15)+TX, aldicarb (16)+TX, aldoxycarb (863)+TX, AZ 60541 (compound code)+TX, benclothiaz [CCN]+TX, benomyl (62)+TX, butylpyridaben (alternative name)+TX, cadusafos (109)+TX, carbofuran (118)+TX, carbon disulfide (945)+TX, carbosulfan (119)+TX, chloropicrin (141)+TX, chlorpyrifos (145)+TX, cloethocarb (999)+TX, Cyclobutrifluram+TX, cytokinins (alternative name) (210)+TX, dazomet (216)+TX, DBCP (1045)+TX, DCIP (218)+TX, diamidafos (1044)+TX, dichlofenthion (1051)+TX, dicliphos (alternative name)+TX, dimethoate (262)+TX, doramectin (alternative name) [CCN]+TX, emamectin (291)+TX, emamectin benzoate (291)+TX, eprinomectin (alternative name) [CCN]+TX, ethoprophos (312)+TX, ethylene dibromide (316)+TX, fenamiphos (326)+TX, fenpyrad (alternative name)+TX, fensulfothion (1158)+TX, fosthiazate (408)+TX, fosthietan (1196)+TX, furfural (alternative name) [CCN]+TX, GY-81 (development code) (423)+TX, heterophos [CCN]+TX, iodomethane (IUPAC name) (542)+TX, isamidofos (1230)+TX, isazofos (1231)+TX, ivermectin (alternative name) [CCN]+TX, kinetin (alternative name) (210)+TX, mecarphon (1258)+TX, metam (519)+TX, metam-potassium (alternative name) (519)+TX, metam-sodium (519)+TX, methyl bromide (537)+TX, methyl isothiocyanate (543)+TX, milbemycin oxime (alternative name) [CCN]+TX, moxidectin (alternative name) [CCN]+TX,  Myrothecium verrucaria  composition (alternative name) (565)+TX, NC-184 (compound code)+TX, oxamyl (602)+TX, phorate (636)+TX, phosphamidon (639)+TX, phosphocarb [CCN]+TX, sebufos (alternative name)+TX, selamectin (alternative name) [CCN]+TX, spinosad (737)+TX, terbam (alternative name)+TX, terbufos (773)+TX, tetrachlorothiophene (IUPAC/Chemical Abstracts name) (1422)+TX, thiafenox (alternative name)+TX, thionazin (1434)+TX, triazophos (820)+TX, triazuron (alternative name)+TX, xylenols [CCN]+TX, YI-5302 (compound code) and zeatin (alternative name) (210)+TX, fluensulfone [318290-98-1] + TX, fluopyram+TX; 
     a nitrification inhibitor selected from the group of substances consisting of potassium ethylxanthate [CCN] and nitrapyrin (580)+TX; 
     a plant activator selected from the group of substances consisting of acibenzolar (6)+TX, acibenzolar-S-methyl (6)+TX, probenazole (658) and  Reynoutria sachalinensis  extract (alternative name) (720)+TX; 
     a rodenticide selected from the group of substances consisting of 2-isovalerylindan-1,3-dione (IUPAC name) (1246)+TX, 4-(quinoxalin-2-ylamino)benzenesulfonamide (IUPAC name) (748)+TX, alpha-chlorohydrin [CCN]+TX, aluminium phosphide (640)+TX, antu (880)+TX, arsenous oxide (882)+TX, barium carbonate (891)+TX, bisthiosemi (912)+TX, brodifacoum (89)+TX, bromadiolone (including alpha-bromadiolone)+TX, bromethalin (92)+TX, calcium cyanide (444)+TX, chloralose (127)+TX, chlorophacinone (140)+TX, cholecalciferol (alternative name) (850)+TX, coumachlor (1004)+TX, coumafuryl (1005)+TX, coumatetralyl (175)+TX, crimidine (1009)+TX, difenacoum (246)+TX, difethialone (249)+TX, diphacinone (273)+TX, ergocalciferol (301)+TX, flocoumafen (357)+TX, fluoroacetamide (379)+TX, flupropadine (1183)+TX, flupropadine hydrochloride (1183)+TX, gamma-HCH (430)+TX, HCH (430)+TX, hydrogen cyanide (444)+TX, iodomethane (IUPAC name) (542)+TX, lindane (430)+TX, magnesium phosphide (IUPAC name) (640)+TX, methyl bromide (537)+TX, norbormide (1318)+TX, phosacetim (1336)+TX, phosphine (IUPAC name) (640)+TX, phosphorus [CCN]+TX, pindone (1341)+TX, potassium arsenite [CCN]+TX, pyrinuron (1371)+TX, scilliroside (1390)+TX, sodium arsenite [CCN]+TX, sodium cyanide (444)+TX, sodium fluoroacetate (735)+TX, strychnine (745)+TX, thallium sulfate [CCN]+TX, warfarin (851) and zinc phosphide (640)+TX; a synergist selected from the group of substances consisting of 2-(2-butoxyethoxy)ethyl piperonylate (IUPAC name) (934)+TX, 5-(1,3-benzodioxol-5-yl)-3-hexylcyclohex-2-enone (IUPAC name) (903)+TX, farnesol with nerolidol (alternative name) (324)+TX, MB-599 (development code) (498)+TX, MGK 264 (development code) (296)+TX, piperonyl butoxide (649)+TX, piprotal (1343)+TX, propyl isomer (1358)+TX, S 421  (development code) (724)+TX, sesamex (1393)+TX, sesasmolin (1394) and sulfoxide (1406)+TX; 
     an animal repellent selected from the group of substances consisting of anthraquinone (32)+TX, chloralose (127)+TX, copper naphthenate [CCN]+TX, copper oxychloride (171)+TX, diazinon (227)+TX, dicyclopentadiene (chemical name) (1069)+TX, guazatine (422)+TX, guazatine acetates (422)+TX, methiocarb (530)+TX, pyridin-4-amine (IUPAC name) (23)+TX, thiram (804)+TX, trimethacarb (840)+TX, zinc naphthenate [CCN] and ziram (856)+TX; a virucide selected from the group of substances consisting of imanin (alternative name) [CCN] and ribavirin (alternative name) [CCN]+TX; 
     a wound protectant selected from the group of substances consisting of mercuric oxide (512)+TX, octhilinone (590) and thiophanate-methyl (802)+TX; 
     a biologically active substance selected from 1,1-bis(4-chloro-phenyl)-2-ethoxyethanol+TX, 2,4-dichlorophenyl benzenesulfonate+TX, 2-fluoro-N-methyl-N-1-naphthylacetamide+TX, 4-chlorophenyl phenyl sulfone+TX, acetoprole+TX, aldoxycarb+TX, amidithion+TX, amidothioate+TX, amiton+TX, amiton hydrogen oxalate+TX, amitraz+TX, aramite+TX, arsenous oxide+TX, azobenzene+TX, azothoate+TX, benomyl+TX, benoxa-fos+TX, benzyl benzoate+TX, bixafen+TX, brofenvalerate+TX, bromo-cyclen+TX, bromophos+TX, bromopropylate+TX, buprofezin+TX, butocarboxim+TX, butoxycarboxim+TX, butylpyridaben+TX, calcium polysulfide+TX, camphechlor+TX, carbanolate+TX, carbophenothion+TX, cymiazole+TX, chino-methionat+TX, chlorbenside+TX, chlordimeform+TX, chlordimeform hydrochloride+TX, chlorfenethol+TX, chlorfenson+TX, chlorfensulfide+TX, chlorobenzilate+TX, chloromebuform+TX, chloromethiuron+TX, chloropropylate+TX, chlorthiophos+TX, cinerin I+TX, cinerin II+TX, cinerins+TX, closantel+TX, coumaphos+TX, crotamiton+TX, crotoxyphos+TX, cufraneb+TX, cyanthoate+TX, DCPM+TX, DDT+TX, demephion+TX, demephion-O+TX, demephion-S+TX, demeton-methyl+TX, demeton-O+TX, demeton-O-methyl+TX, demeton-S+TX, demeton-S-methyl+TX, demeton-S-methylsulfon+TX, dichlofluanid+TX, dichlorvos+TX, dicliphos+TX, dienochlor+TX, dimefox+TX, dinex+TX, dinex-diclexine+TX, dinocap-4+TX, dinocap-6+TX, dinocton+TX, dino-penton+TX, dinosulfon+TX, dinoterbon+TX, dioxathion+TX, diphenyl sulfone+TX, disulfiram+TX, DNOC+TX, dofenapyn+TX, doramectin+TX, endothion+TX, eprinomectin+TX, ethoate-methyl+TX, etrimfos+TX, fenazaflor+TX, fenbutatin oxide+TX, fenothiocarb+TX, fenpyrad+TX, fen-pyroximate+TX, fenpyrazamine+TX, fenson+TX, fentrifanil+TX, flubenzimine+TX, flucycloxuron+TX, fluenetil+TX, fluorbenside+TX, FMC 1137+TX, formetanate+TX, formetanate hydrochloride+TX, formparanate+TX, gamma-HCH+TX, glyodin+TX, halfenprox+TX, hexadecyl cyclopropanecarboxylate+TX, isocarbophos+TX, jasmolin I+TX, jasmolin II+TX, jodfenphos+TX, lindane+TX, malonoben+TX, mecarbam+TX, mephosfolan+TX, mesulfen+TX, methacrifos+TX, methyl bromide+TX, metolcarb+TX, mexacarbate+TX, milbemycin oxime+TX, mipafox+TX, monocrotophos+TX, morphothion+TX, moxidectin+TX, naled+TX, 4-chloro-2-(2-chloro-2-methyl-propyl)-5-[(6-iodo-3-pyridyl)methoxy]pyridazin-3-one+TX, nifluridide+TX, nikkomycins+TX, nitrilacarb+TX, nitrilacarb 1:1 zinc chloride complex+TX, omethoate+TX, oxydeprofos+TX, oxydisulfoton+TX, pp′-DDT+TX, parathion+TX, permethrin+TX, phenkapton+TX, phosalone+TX, phosfolan+TX, phosphamidon+TX, polychloroterpenes+TX, polynactins+TX, proclonol+TX, promacyl+TX, propoxur+TX, prothidathion+TX, prothoate+TX, pyrethrin I+TX, pyrethrin II+TX, pyrethrins+TX, pyridaphenthion+TX, pyrimitate+TX, quinalphos+TX, quintiofos+TX, R-1492+TX, phosglycin+TX, rotenone+TX, schradan+TX, sebufos+TX, selamectin+TX, sophamide+TX, SSI-121+TX, sulfiram+TX, sulfluramid+TX, sulfotep+TX, sulfur+TX, diflovidazin+TX, tau-fluvalinate+TX, TEPP+TX, terbam+TX, tetradifon+TX, tetrasul+TX, thiafenox+TX, thiocarboxime+TX, thiofanox+TX, thiometon+TX, thioquinox+TX, thuringiensin+TX, triamiphos+TX, triarathene+TX, triazophos+TX, triazuron+TX, trifenofos+TX, trinactin+TX, vamidothion+TX, vaniliprole+TX, bethoxazin+TX, copper dioctanoate+TX, copper sulfate+TX, cybutryne+TX, dichlone+TX, dichlorophen+TX, endothal+TX, fentin+TX, hydrated lime+TX, nabam+TX, quinoclamine+TX, quinonamid+TX, simazine+TX, triphenyltin acetate+TX, triphenyltin hydroxide+TX, crufomate+TX, piperazine+TX, thiophanate+TX, chloralose+TX, fenthion+TX, pyridin-4-amine+TX, strychnine+TX, 1-hydroxy-1H-pyridine-2-thione+TX, 4-(quinoxalin-2-ylamino)benzenesulfonamide+TX, 8-hydroxyquinoline sulfate+TX, bronopol+TX, copper hydroxide+TX, cresol+TX, dipyrithione+TX, dodicin+TX, fenaminosulf+TX, formaldehyde+TX, hydrargaphen+TX, kasugamycin+TX, kasugamycin hydrochloride hydrate+TX, nickel bis(dimethyldithiocarbamate)+TX, nitrapyrin+TX, octhilinone+TX, oxolinic acid+TX, oxytetracycline+TX, potassium hydroxyquinoline sulfate+TX, probenazole+TX, streptomycin+TX, streptomycin sesquisulfate+TX, tecloftalam+TX, thiomersal+TX,  Adoxophyes orana  GV+TX,  Agrobacterium radiobacter +TX,  Amblyseius  spp.+TX,  Anagrapha falcifera  NPV+TX,  Anagrus atomus +TX,  Aphelinus abdominalis +TX,  Aphidius colemani +TX,  Aphidoletes aphidimyza +TX,  Autographa californica  NPV+TX,  Bacillus sphaericus  Neide+TX,  Beauveria brongniartii +TX,  Chrysoperla carnea +TX,  Cryptolaemus montrouzieri +TX,  Cydia pomonella  GV+TX,  Dacnusa sibirica +TX,  Diglyphus isaea +TX,  Encarsia formosa +TX,  Eretmocerus eremicus +TX,  Heterorhabditis bacteriophora  and  H. megidis +TX,  Hippodamia convergens +TX,  Leptomastix dactylopii +TX,  Macrolophus caliginosus +TX,  Mamestra brassicae  NPV+TX,  Metaphycus helvolus +TX,  Metarhizium anisopliae  var.  acridum +TX,  Metarhizium anisopliae  var.  anisopliae +TX,  Neodiprion sertifer  NPV and  N. lecontei  NPV+TX,  Orius  spp.+TX,  Paecilomyces fumosoroseus +TX,  Phytoseiulus persimilis +TX,  Steinernema bibionis +TX,  Steinernema carpocapsae +TX,  Steinernema feltiae +TX,  Steinernema glaseri +TX,  Steinernema riobrave +TX,  Steinernema riobravis +TX,  Steinernema scapterisci +TX,  Steinernema  spp.+TX,  Trichogramma  spp.+TX,  Typhlodromus occidentalis +TX,  Verticillium lecanii +TX, apholate+TX, bisazir+TX, busulfan+TX, dimatif+TX, hemel+TX, hempa+TX, metepa+TX, methiotepa+TX, methyl apholate+TX, morzid+TX, penfluron+TX, tepa+TX, thiohempa+TX, thiotepa+TX, tretamine+TX, uredepa+TX, (E)-dec-5-en-1-yl acetate with (E)-dec-5-en-1-ol+TX, (E)-tridec-4-en-1-yl acetate+TX, (E)-6-methylhept-2-en-4-ol+TX, (E,Z)-tetradeca-4,10-dien-1-yl acetate+TX, (Z)-dodec-7-en-1-yl acetate+TX, (Z)-hexadec-11-enal+TX, (Z)-hexadec-11-en-1-yl acetate+TX, (Z)-hexadec-13-en-11-yn-1-yl acetate+TX, (Z)-icos-13-en-10-one+TX, (Z)-tetradec-7-en-1-al+TX, (Z)-tetradec-9-en-1-ol+TX, (Z)-tetradec-9-en-1-yl acetate+TX, (7E,9Z)-dodeca-7,9-dien-1-yl acetate+TX, (9Z,11E)-tetradeca-9,11-dien-1-yl acetate+TX, (9Z,12E)-tetradeca-9,12-dien-1-yl acetate+TX, 14-methyloctadec-1-ene+TX, 4-methylnonan-5-ol with 4-methylnonan-5-one+TX, alpha-multistriatin+TX, brevicomin+TX, codlelure+TX, codlemone+TX, cuelure+TX, disparlure+TX, dodec-8-en-1-yl acetate+TX, dodec-9-en-1-yl acetate+TX, dodeca-8+TX, 10-dien-1-yl acetate+TX, dominicalure+TX, ethyl 4-methyloctanoate+TX, eugenol+TX, frontalin+TX, grandlure+TX, grandlure I+TX, grandlure II+TX, grandlure III+TX, grandlure IV+TX, hexalure+TX, ipsdienol+TX, ipsenol+TX, japonilure+TX, lineatin+TX, litlure+TX, looplure+TX, medlure+TX, megatomoic acid+TX, methyl eugenol+TX, muscalure+TX, octadeca-2,13-dien-1-yl acetate+TX, octadeca-3,13-dien-1-yl acetate+TX, orfralure+TX, oryctalure+TX, ostramone+TX, siglure+TX, sordidin+TX, sulcatol+TX, tetradec-11-en-1-yl acetate+TX, trimedlure+TX, trimedlure A+TX, trimedlure B 1 +TX, trimedlure B 2 +TX, trimedlure C+TX, trunc-call+TX, 2-(octylthio)-ethanol+TX, butopyronoxyl+TX, butoxy(polypropylene glycol)+TX, dibutyl adipate+TX, dibutyl phthalate+TX, dibutyl succinate+TX, diethyltoluamide+TX, dimethyl carbate+TX, dimethyl phthalate+TX, ethyl hexanediol+TX, hexamide+TX, methoquin-butyl+TX, methylneodecanamide+TX, oxamate+TX, picaridin+TX, 1-dichloro-1-nitroethane+TX, 1,1-dichloro-2,2-bis(4-ethylphenyl)-ethane+TX, 1,2-dichloropropane with 1,3-dichloropropene+TX, 1-bromo-2-chloroethane+TX, 2,2,2-trichloro-1-(3,4-dichloro-phenyl)ethyl acetate+TX, 2,2-dichlorovinyl 2-ethylsulfinylethyl methyl phosphate+TX, 2-(1,3-dithiolan-2-yl)phenyl dimethylcarbamate+TX, 2-(2-butoxyethoxy)ethyl thiocyanate+TX, 2-(4,5-dimethyl-1,3-dioxolan-2-yl)phenyl methylcarbamate+TX, 2-(4-chloro-3,5-xylyloxy)ethanol+TX, 2-chlorovinyl diethyl phosphate+TX, 2-imidazolidone+TX, 2-isovalerylindan-1,3-dione+TX, 2-methyl(prop-2-ynyl)aminophenyl methylcarbamate+TX, 2-thiocyanatoethyl laurate+TX, 3-bromo-1-chloroprop-1-ene+TX, 3-methyl-1-phenylpyrazol-5-yl dimethyl-carbamate+TX, 4-methyl(prop-2-ynyl)amino-3,5-xylyl methylcarbamate+TX, 5,5-dimethyl-3-oxocyclohex-1-enyl dimethylcarbamate+TX, acethion+TX, acrylonitrile+TX, aldrin+TX, allosamidin+TX, allyxycarb+TX, alpha-ecdysone+TX, aluminium phosphide+TX, aminocarb+TX, anabasine+TX, athidathion+TX, azamethiphos+TX,  Bacillus thuringiensis  delta endotoxins+TX, barium hexafluorosilicate+TX, barium polysulfide+TX, barthrin+TX, Bayer 22/190+TX, Bayer 22408+TX, beta-cyfluthrin+TX, beta-cypermethrin+TX, bioethanomethrin+TX, biopermethrin+TX, bis(2-chloroethyl) ether+TX, borax+TX, bromfenvinfos+TX, bromo-DDT+TX, bufencarb+TX, butacarb+TX, butathiofos+TX, butonate+TX, calcium arsenate+TX, calcium cyanide+TX, carbon disulfide+TX, carbon tetrachloride+TX, cartap hydrochloride+TX, cevadine+TX, chlorbicyclen+TX, chlordane+TX, chlordecone+TX, chloroform+TX, chloropicrin+TX, chlorphoxim+TX, chlorprazophos+TX, cis-resmethrin+TX, cismethrin+TX, clocythrin+TX, copper acetoarsenite+TX, copper arsenate+TX, copper oleate+TX, coumithoate+TX, cryolite+TX, CS 708+TX, cyanofenphos+TX, cyanophos+TX, cyclethrin+TX, cythioate+TX, d-tetramethrin+TX, DAEP+TX, dazomet+TX, decarbofuran+TX, diamidafos+TX, dicapthon+TX, dichlofenthion+TX, dicresyl+TX, dicyclanil+TX, dieldrin+TX, diethyl 5-methylpyrazol-3-yl phosphate+TX, dilor+TX, dimefluthrin+TX, dimetan+TX, dimethrin+TX, dimethylvinphos+TX, dimetilan+TX, dinoprop+TX, dinosam+TX, dinoseb+TX, diofenolan+TX, dioxabenzofos+TX, dithicrofos+TX, DSP+TX, ecdysterone+TX, El 1642+TX, EMPC+TX, EPBP+TX, etaphos+TX, ethiofencarb+TX, ethyl formate+TX, ethylene dibromide+TX, ethylene dichloride+TX, ethylene oxide+TX, EXD+TX, fenchlorphos+TX, fenethacarb+TX, fenitrothion+TX, fenoxacrim+TX, fenpirithrin+TX, fensulfothion+TX, fenthion-ethyl+TX, flucofuron+TX, fosmethilan+TX, fospirate+TX, fosthietan+TX, furathiocarb+TX, furethrin+TX, guazatine+TX, guazatine acetates+TX, sodium tetrathiocarbonate+TX, halfenprox+TX, HCH+TX, HEOD+TX, heptachlor+TX, heterophos+TX, HHDN+TX, hydrogen cyanide+TX, hyquincarb+TX, IPSP+TX, isazofos+TX, isobenzan+TX, isodrin+TX, isofenphos+TX, isolane+TX, isoprothiolane+TX, isoxathion+TX, juvenile hormone I+TX, juvenile hormone II+TX, juvenile hormone III+TX, kelevan+TX, kinoprene+TX, lead arsenate+TX, leptophos+TX, lirimfos+TX, lythidathion+TX, m-cumenyl methylcarbamate+TX, magnesium phosphide+TX, mazidox+TX, mecarphon+TX, menazon+TX, mercurous chloride+TX, mesulfenfos+TX, metam+TX, metam-potassium+TX, metam-sodium+TX, methanesulfonyl fluoride+TX, methocrotophos+TX, methoprene+TX, methothrin+TX, methoxychlor+TX, methyl isothiocyanate+TX, methylchloroform+TX, methylene chloride+TX, metoxadiazone+TX, mirex+TX, naftalofos+TX, naphthalene+TX, NC-170+TX, nicotine+TX, nicotine sulfate+TX, nithiazine+TX, nornicotine+TX, 0-5-dichloro-4-iodophenyl O-ethyl ethylphosphonothioate+TX, O,O-diethyl 0-4-methyl-2-oxo-2H-chromen-7-yl phosphorothioate+TX, O,O-diethyl 0-6-methyl-2-propylpyrimidin-4-yl phosphorothioate+TX, O,O,O ′,O′-tetrapropyl dithiopyrophosphate+TX, oleic acid+TX, para-dichlorobenzene+TX, parathion-methyl+TX, pentachlorophenol+TX, pentachlorophenyl laurate+TX, PH 60-38+TX, phenkapton+TX, phosnichlor+TX, phosphine+TX, phoxim-methyl+TX, pirimetaphos+TX, polychlorodicyclopentadiene isomers+TX, potassium arsenite+TX, potassium thiocyanate+TX, precocene I+TX, precocene II+TX, precocene III+TX, primidophos+TX, profluthrin+TX, promecarb+TX, prothiofos+TX, pyrazophos+TX, pyresmethrin+TX, quassia+TX, quinalphos-methyl+TX, quinothion+TX, rafoxanide+TX, resmethrin+TX, rotenone+TX, kadethrin+TX, ryania+TX, ryanodine+TX, sabadilla)+TX, schradan+TX, sebufos+TX, SI-0009+TX, thiapronil+TX, sodium arsenite+TX, sodium cyanide+TX, sodium fluoride+TX, sodium hexafluorosilicate+TX, sodium pentachlorophenoxide+TX, sodium selenate+TX, sodium thiocyanate+TX, sulcofuron+TX, sulcofuron-sodium+TX, sulfuryl fluoride+TX, sulprofos+TX, tar oils+TX, tazimcarb+TX, TDE+TX, tebupirimfos+TX, temephos+TX, terallethrin+TX, tetrachloroethane+TX, thicrofos+TX, thiocyclam+TX, thiocyclam hydrogen oxalate+TX, thionazin+TX, thiosultap+TX, thiosultap-sodium+TX, tralomethrin+TX, transpermethrin+TX, triazamate+TX, trichlormetaphos-3+TX, trichloronat+TX, trimethacarb+TX, tolprocarb+TX, triclopyricarb+TX, triprene+TX, veratridine+TX, veratrine+TX, XMC+TX, zetamethrin+TX, zinc phosphide+TX, zolaprofos+TX and meperfluthrin+TX, tetramethylfluthrin+TX, bis(tributyltin) oxide+TX, bromoacetamide+TX, ferric phosphate+TX, niclosamide-olamine+TX, tributyltin oxide+TX, pyrimorph+TX, trifenmorph+TX, 1,2-dibromo-3-chloropropane+TX, 1,3-dichloropropene+TX, 3,4-dichlorotetrahydrothio-phene 1,1-dioxide+TX, 3-(4-chlorophenyl)-5-methylrhodanine+TX, 5-methyl-6-thioxo-1,3,5-thiadiazinan-3-ylacetic acid+TX, 6-isopentenylaminopurine+TX, 2-fluoro-N-(3-methoxyphenyl)-9H-purin-6-amine+TX, benclothiaz+TX, cytokinins+TX, DCIP+TX, furfural+TX, isamidofos+TX, kinetin+TX,  Myrothecium verrucaria  composition+TX, tetrachlorothiophene+TX, xylenols+TX, zeatin+TX, potassium ethylxanthate+TX, acibenzolar+TX, acibenzolar-S-methyl+TX,  Reynoutria sachalinensis  extract+TX, alpha-chlorohydrin+TX, antu+TX, barium carbonate+TX, bisthiosemi+TX, brodifacoum+TX, bromadiolone+TX, bromethalin+TX, chlorophacinone+TX, cholecalciferol+TX, coumachlor+TX, coumafuryl+TX, coumatetralyl+TX, crimidine+TX, difenacoum+TX, difethialone+TX, diphacinone+TX, ergocalciferol+TX, flocoumafen+TX, fluoroacetamide+TX, flupropadine+TX, flupropadine hydrochloride+TX, norbormide+TX, phosacetim+TX, phosphorus+TX, pindone+TX, pyrinuron+TX, scilliroside+TX, -sodium fluoroacetate+TX, thallium sulfate+TX, warfarin+TX, -2-(2-butoxyethoxy)ethyl piperonylate+TX, 5-(1,3-benzodioxol-5-yl)-3-hexylcyclohex-2-enone+TX, farnesol with nerolidol+TX, verbutin+TX, MGK 264+TX, piperonyl butoxide+TX, piprotal+TX, propyl isomer+TX, S421+TX, sesamex+TX, sesasmolin+TX, sulfoxide+TX, anthraquinone+TX, copper naphthenate+TX, copper oxychloride+TX, dicyclopentadiene+TX, thiram+TX, zinc naphthenate+TX, ziram+TX, imanin+TX, ribavirin+TX, chloroinconazide+TX, mercuric oxide+TX, thiophanate-methyl+TX, azaconazole+TX, bitertanol+TX, bromuconazole+TX, cyproconazole+TX, difenoconazole+TX, diniconazole-+TX, epoxiconazole+TX, fenbuconazole+TX, fluquinconazole+TX, flusilazole+TX, flutriafol+TX, furametpyr+TX, hexaconazole+TX, imazalil-+TX, imiben-conazole+TX, ipconazole+TX, metconazole+TX, myclobutanil+TX, paclobutrazole+TX, pefurazoate+TX, penconazole+TX, prothioconazole+TX, pyrifenox+TX, prochloraz+TX, propiconazole+TX, pyrisoxazole+TX, -simeconazole+TX, tebucon-azole+TX, tetraconazole+TX, triadimefon+TX, triadimenol+TX, triflumizole+TX, triticonazole+TX, ancymidol+TX, fenarimol+TX, nuarimol+TX, bupirimate+TX, dimethirimol+TX, ethirimol+TX, dodemorph+TX, fenpropidin+TX, fenpropimorph+TX, spiroxamine+TX, tridemorph+TX, cyprodinil+TX, mepanipyrim+TX, pyrimethanil+TX, fenpiclonil+TX, fludioxonil+TX, benalaxyl+TX, furalaxyl+TX, -metalaxyl-+TX, Rmetalaxyl+TX, ofurace+TX, oxadixyl+TX, carbendazim+TX, debacarb+TX, fuberidazole-+TX, thiabendazole+TX, chlozolinate+TX, dichlozoline+TX, myclozoline-+TX, procymidone+TX, vinclozoline+TX, boscalid+TX, carboxin+TX, fenfuram+TX, flutolanil+TX, mepronil+TX, oxycarboxin+TX, penthiopyrad+TX, thifluzamide+TX, dodine+TX, iminoctadine+TX, azoxystrobin+TX, dimoxystrobin+TX, enestroburin+TX, fenaminstrobin+TX, flufenoxystrobin+TX, fluoxastrobin+TX, kresoxim-methyl+TX, metominostrobin+TX, trifloxystrobin+TX, orysastrobin+TX, picoxystrobin+TX, pyraclostrobin+TX, pyrametostrobin+TX, pyraoxystrobin+TX, ferbam+TX, mancozeb+TX, maneb+TX, metiram+TX, propineb+TX, zineb+TX, captafol+TX, captan+TX, fluoroimide+TX, folpet+TX, tolylfluanid+TX, bordeaux mixture+TX, copper oxide+TX, mancopper+TX, oxine-copper+TX, nitrothal-isopropyl+TX, edifenphos+TX, iprobenphos+TX, phosdiphen+TX, tolclofos-methyl+TX, anilazine+TX, benthiavalicarb+TX, blasticidin-S+TX, chloroneb-+TX, chloro-tha-lonil+TX, cyflufenamid+TX, cymoxanil+TX, cyclobutrifluram+TX, diclocymet+TX, diclomezine-+TX, dicloran+TX, diethofencarb+TX, dimethomorph-+TX, flumorph+TX, dithianon+TX, ethaboxam+TX, etridiazole+TX, famoxadone+TX, fenamidone+TX, fenoxanil+TX, ferimzone+TX, fluazinam+TX, fluopicolide+TX, flusulfamide+TX, fluxapyroxad+TX,-fenhexamid+TX, fosetyl-aluminium-+TX, hymexazol+TX, iprovalicarb+TX, cyazofamid+TX, methasulfocarb+TX, metrafenone+TX, pencycuron+TX, phthalide+TX, polyoxins+TX, propamocarb+TX, pyribencarb+TX, proquinazid+TX, pyroquilon+TX, pyriofenone+TX, quinoxyfen+TX, quintozene+TX, tiadinil+TX, triazoxide+TX, tricyclazole+TX, triforine+TX, validamycin+TX, valifenalate+TX, zoxamide+TX, mandipropamid+TX, flubeneteram+TX, isopyrazam+TX, sedaxane+TX, benzovindiflupyr+TX, pydiflumetofen+TX, 3-difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid (3′,4′,5′-trifluoro-biphenyl-2-yl)-amide+TX, isoflucypram+TX, isotianil+TX, dipymetitrone+TX, 6-ethyl-5,7-dioxo-pyrrolo[4,5][1,4]dithiino[1,2-c]isothiazole-3-carbonitrile+TX, 2-(difluoromethyl)-N-[3-ethyl-1,1-dimethyl-indan-4-yl]pyridine-3-carboxamide+TX, 4-(2,6-difluorophenyl)-6-methyl-5-phenyl-pyridazine-3-carbonitrile+TX, (R)-3-(difluoromethyl)-1-methyl-N-[1,1,3-trimethylindan-4-yl]pyrazole-4-carboxamide+TX, 4-(2-bromo-4-fluoro-phenyl)-N-(2-chloro-6-fluoro-phenyl)-2,5-dimethyl-pyrazol-3-amine+TX, 4-(2-bromo-4-fluorophenyl)-N-(2-chloro-6-fluorophenyl)-1, 3-dimethyl-1H-pyrazol-5-amine+TX, fluindapyr+TX, coumethoxystrobin (jiaxiangjunzhi)+TX, Ivbenmixianan+TX, dichlobentiazox+TX, mandestrobin+TX, 3-(4,4-difluoro-3,4-dihydro-3,3-dimethylisoquinolin-1-yl)quinolone+TX, 2-[2-fluoro-6-[(8-fluoro-2-methyl-3-quinolyl)oxy]phenyl]propan-2-ol+TX, oxathiapiprolin+TX, tert-butyl N-[6-[[[(1-methyltetrazol-5-yl)-phenyl-methylene]amino]oxymethyl]-2-pyridyl]carbamate+TX, pyraziflumid+TX, inpyrfluxam+TX, trolprocarb+TX, mefentrifluconazole+TX, ipfentrifluconazole+TX, 2-(difluoromethyl)-N-[(3R)-3-ethyl-1,1-dimethyl-indan-4-yl]pyridine-3-carboxamide+TX, N′-(2,5-dimethyl-4-phenoxy-phenyl)-N-ethyl-N-methyl-formamidine+TX, N′-[4-(4,5-dichlorothiazol-2-yl)oxy-2,5-dimethyl-phenyl]-N-ethyl-N-methyl-formamidine+TX, [2-[3-[2-[1-[2-[3,5-bis(difluoromethyl)pyrazol-1-yl]acetyl]-4-piperidyl]thiazol-4-yl]-4,5-dihydroisoxazol-5-yl]-3-chloro-phenyl] methanesulfonate+TX, but-3-ynyl N-[6-[[(Z)-[(1-methyltetrazol-5-yl)-phenyl-methylene]amino]oxymethyl]-2-pyridyl]carbamate+TX, methyl N-[[5-[4-(2,4-dimethylphenyl)triazol-2-yl]-2-methyl-phenyl]methyl]carbamate+TX, 3-chloro-6-methyl-5-phenyl-4-(2,4,6-trifluorophenyl)pyridazine+TX, pyridachlometyl+TX, 3-(difluoromethyl)-1-methyl-N-[1,1,3-trimethylindan-4-yl]pyrazole-4-carboxamide+TX, 1-[2-[[1-(4-chlorophenyl)pyrazol-3-yl]oxymethyl]-3-methyl-phenyl]-4-methyl-tetrazol-5-one+TX, 1-methyl-4-[3-methyl-2-[[2-methyl-4-(3,4,5-trimethylpyrazol-1-yl)phenoxy]methyl]phenyl]tetrazol-5-one+TX, aminopyrifen+TX, ametoctradin+TX, amisulbrom+TX, penflufen+TX, (Z,2E)-5-[1-(4-chlorophenyl)pyrazol-3-yl]oxy-2-methoxyimino-N,3-dimethyl-pent-3-enamide+TX, florylpicoxamid+TX, fenpicoxamid+TX, tebufloquin+TX, ipflufenoquin+TX, quinofumelin+TX, isofetamid+TX, N-[2-[2,4-dichloro-phenoxy]phenyl]-3-(difluoromethyl)-1-methyl-pyrazole-4-carboxamide+TX, N-[2-[2-chloro-4-(trifluoromethyl)phenoxy]phenyl]-3-(difluoromethyl)-1-methyl-pyrazole-4-carboxamide+TX, benzothiostrobin+TX, phenamacril+TX, 5-amino-1,3,4-thiadiazole-2-thiol zinc salt (2:1)+TX, fluopyram+TX, flutianil+TX, fluopimomide+TX, pyrapropoyne+TX, picarbutrazox+TX, 2-(difluoromethyl)-N-(3-ethyl-1,1-dimethyl-indan-4-yl)pyridine-3-carboxamide+TX, 2-(difluoromethyl)-N-((3R)-1, 1, 3-trimethylindan-4-yl) pyridine-3-carboxamide+TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile+TX, metyltetraprole+TX, 2-(difluoromethyl)-N-((3R)-1, 1, 3-trimethylindan-4-yl) pyridine-3-carboxamide+TX, α-(1, 1-dimethylethyl)-α-[4′-(trifluoromethoxy) [1, 1′-biphenyl]-4-yl]-5-pyrimidinemethanol+TX, fluoxapiprolin+TX, enoxastrobin+TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy] benzonitrile+TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-sulfanyl-1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy] benzonitrile+TX, 4-[[6-[2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(5-thioxo-4H-1,2,4-triazol-1-yl)propyl]-3-pyridyl]oxy]benzonitrile+TX, trinexapac+TX, coumoxystrobin+TX, zhongshengmycin+TX, thiodiazole copper+TX, zinc thiazole+TX, amectotractin+TX, iprodione+TX, N-octyl-N′-[2-(octylamino)ethyl]ethane-1,2-diamine+TX; N′-[5-bromo-2-methyl-6-[(1S)-1-methyl-2-propoxy-ethoxy]-3-pyridyl]-N-ethyl-N-methyl-formamidine+TX, N′-[5-bromo-2-methyl-6-[(1R)-1-methyl-2-propoxy-ethoxy]-3-pyridyl]-N-ethyl-N-methyl-formamidine+TX, N′-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine+TX, N′-[5-chloro-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine+TX, N′-[5-bromo-2-methyl-6-(1-methyl-2-propoxy-ethoxy)-3-pyridyl]-N-isopropyl-N-methyl-formamidine+TX (these compounds may be prepared from the methods described in WO2015/155075); N′-[5-bromo-2-methyl-6-(2-propoxypropoxy)-3-pyridyl]-N-ethyl-N-methyl-formamidine+TX (this compound may be prepared from the methods described in IPCOM000249876D); N-isopropyl-N′-[5-methoxy-2-methyl-4-(2,2,2-trifluoro-1-hydroxy-1-phenyl-ethyl)phenyl]-N-methyl-formamidine+TX, N′-[4-(1-cyclopropyl-2,2,2-trifluoro-1-hydroxy-ethyl)-5-methoxy-2-methyl-phenyl]-N-isopropyl-N-methyl-formamidine+TX (these compounds may be prepared from the methods described in WO2018/228896); N-ethyl-N′-[5-methoxy-2-methyl-4-[(2-trifluoromethyl)oxetan-2-yl]phenyl]-N-methyl-formamidine+TX, N-ethyl-N′-[5-methoxy-2-methyl-4-[(2-trifluoromethyl)tetrahydrofuran-2-yl]phenyl]-N-methyl-formamidine+TX (these compounds may be prepared from the methods described in WO2019/110427); N-[(1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide+TX, N-[(1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl]-8-fluoro-quinoline-3-carboxamide+TX, N-[(1R)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide+TX, N-[(1S)-1-benzyl-3,3,3-trifluoro-1-methyl-propyl]-8-fluoro-quinoline-3-carboxamide+TX, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide+TX, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-7,8-difluoro-quinoline-3-carboxamide+TX, 8-fluoro-N-[(1R)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide+TX, 8-fluoro-N-[(1S)-1-[(3-fluorophenyl)methyl]-1,3-dimethyl-butyl]quinoline-3-carboxamide+TX, N-[(1R)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide+TX, N-[(1S)-1-benzyl-1,3-dimethyl-butyl]-8-fluoro-quinoline-3-carboxamide+TX, N-((1R)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide+TX, N-((1S)-1-benzyl-3-chloro-1-methyl-but-3-enyl)-8-fluoro-quinoline-3-carboxamide+TX (these compounds may be prepared from the methods described in WO2017/153380); 1-(6,7-dimethylpyrazolo[1,5-a]pyridin-3-yl)-4,4,5-trifluoro-3,3-dimethyl-isoquinoline+TX, 1-(6,7-dimethylpyrazolo[1,5-a]pyridin-3-yl)-4,4,6-trifluoro-3,3-dimethyl-isoquinoline+TX, 4,4-difluoro-3,3-dimethyl-1-(6-methylpyrazolo[1,5-a]pyridin-3-yl)isoquinoline+TX, 4,4-difluoro-3,3-dimethyl-1-(7-methylpyrazolo[1,5-a]pyridin-3-yl)isoquinoline+TX, 1-(6-chloro-7-methyl-pyrazolo[1,5-a]pyridin-3-yl)-4,4-difluoro-3,3-dimethyl-isoquinoline+TX (these compounds may be prepared from the methods described in WO2017/025510); 1-(4,5-dimethylbenzimidazol-1-yl)-4,4,5-trifluoro-3,3-dimethyl-isoquinoline+TX, 1-(4,5-dimethylbenzimidazol-1-yl)-4,4-difluoro-3,3-dimethyl-isoquinoline+TX, 6-chloro-4,4-difluoro-3,3-dimethyl-1-(4-methylbenzimidazol-1-yl)isoquinoline+TX, 4,4-difluoro-1-(5-fluoro-4-methyl-benzimidazol-1-yl)-3,3-dimethyl-isoquinoline+TX, 3-(4,4-difluoro-3,3-dimethyl-1-isoquinolyl)-7,8-dihydro-6H-cyclopenta[e]benzimidazole+TX (these compounds may be prepared from the methods described in WO2016/156085); N-methoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]cyclopropanecarboxamide+TX, N,2-dimethoxy-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide+TX, N-ethyl-2-methyl-N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide+TX, 1-methoxy-3-methyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea+TX, 1,3-dimethoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea+TX, 3-ethyl-1-methoxy-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]urea+TX, N-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]propanamide+TX, 4,4-dimethyl-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolidin-3-one+TX, 5,5-dimethyl-2-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]isoxazolidin-3-one+TX, ethyl 1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]pyrazole-4-carboxylate+TX, N,N-dimethyl-1-[[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methyl]-1,2,4-triazol-3-amine+TX. The compounds in this paragraph may be prepared from the methods described in WO 2017/055473, WO 2017/055469, WO 2017/093348 and WO 2017/118689; 2-[6-(4-chlorophenoxy)-2-(trifluoromethyl)-3-pyridyl]-1-(1,2,4-triazol-1-yl)propan-2-ol+TX (this compound may be prepared from the methods described in WO 2017/029179); 2-[6-(4-bromophenoxy)-2-(trifluoromethyl)-3-pyridyl]-1-(1,2,4-triazol-1-yl)propan-2-ol+TX (this compound may be prepared from the methods described in WO 2017/029179); 3-[2-(1-chlorocyclopropyl)-3-(2-fluorophenyl)-2-hydroxy-propyl]imidazole-4-carbonitrile+TX (this compound may be prepared from the methods described in WO 2016/156290); 3-[2-(1-chlorocyclopropyl)-3-(3-chloro-2-fluoro-phenyl)-2-hydroxy-propyl]imidazole-4-carbonitrile+TX (this compound may be prepared from the methods described in WO 2016/156290); (4-phenoxyphenyl)methyl 2-amino-6-methyl-pyridine-3-carboxylate+TX (this compound may be prepared from the methods described in WO 2014/006945); 2,6-Dimethyl-1H,5H-[1,4]dithiino[2,3-c:5,6-c′]dipyrrole-1,3,5,7(2H,6H)-tetrone+TX (this compound may be prepared from the methods described in WO 2011/138281); N-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzenecarbothioamide+TX; N-methyl-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide+TX; (Z,2E)-5-[1-(2,4-dichlorophenyl)pyrazol-3-yl]oxy-2-methoxyimino-N,3-dimethyl-pent-3-enamide+TX (this compound may be prepared from the methods described in WO 2018/153707); N′-(2-chloro-5-methyl-4-phenoxy-phenyl)-N-ethyl-N-methyl-formamidine+TX; N′-[2-chloro-4-(2-fluorophenoxy)-5-methyl-phenyl]-N-ethyl-N-methyl-formamidine+TX (this compound may be prepared from the methods described in WO 2016/202742); 2-(difluoromethyl)-N-[(3S)-3-ethyl-1,1-dimethyl-indan-4-yl]pyridine-3-carboxamide+TX (this compound may be prepared from the methods described in WO 2014/095675); (5-methyl-2-pyridyl)-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methanone+TX, (3-methylisoxazol-5-yl)-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]methanone+TX (these compounds may be prepared from the methods described in WO 2017/220485); 2-oxo-N-propyl-2-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide+TX (this compound may be prepared from the methods described in WO 2018/065414); ethyl 1-[[5-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]-2-thienyl]methyl]pyrazole-4-carboxylate+TX (this compound may be prepared from the methods described in WO 2018/158365); 2,2-difluoro-N-methyl-2-[4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]phenyl]acetamide+TX, N-[(E)-methoxyiminomethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide+TX, N—[(Z)-methoxyiminomethyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide+TX, N—[N-methoxy-C-methyl-carbonimidoyl]-4-[5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl]benzamide+TX (these compounds may be prepared from the methods described in WO 2018/202428); 
     microbials including:  Acinetobacter Iwoffii +TX,  Acremonium alternatum +TX+TX,  Acremonium cephalosporium +TX+TX,  Acremonium diospyri +TX,  Acremonium obclavatum +TX,  Adoxophyes orana granulovirus  (AdoxGV) (Capex®)+TX,  Agrobacterium radiobacter  strain K84 (Galltrol-A®)+TX,  Alternaria alternate +TX,  Alternaria cassia +TX,  Alternaria destruens  (Smolder®)+TX,  Ampelomyces quisqualis  (AQ10®)+TX,  Aspergillus flavus  AF36 (AF36®)+TX,  Aspergillus flavus  NRRL 21882 (Aflaguard®)+TX,  Aspergillus  spp.+TX,  Aureobasidium pullulans +TX,  Azospirillum +TX, (MicroAZ®+TX, TAZO B®)+TX,  Azotobacter +TX,  Azotobacter chroocuccum  (Azotomeal®)+TX,  Azotobacter  cysts (Bionatural Blooming Blossoms®)+TX,  Bacillus amyloliquefaciens +TX,  Bacillus cereus +TX,  Bacillus chitinosporus  strain CM-1+TX,  Bacillus chitinosporus  strain AQ746+TX,  Bacillus licheniformis  strain HB-2 (Biostart™ Rhizoboost®)+TX,  Bacillus licheniformis  strain 3086 (EcoGuard®+TX, Green Releaf®)+TX,  Bacillus circulans +TX,  Bacillus firmus  (BioSafe®+TX, BioNem-WP®+TX, VOTiVO®)+TX,  Bacillus firmus  strain 1-1582+TX,  Bacillus macerans +TX,  Bacillus marismortui +TX,  Bacillus megaterium +TX,  Bacillus mycoides  strain AQ726+TX,  Bacillus papillae  (Milky Spore Powder®)+TX,  Bacillus pumilus  spp.+TX,  Bacillus pumilus  strain GB34 (Yield Shield®)+TX,  Bacillus pumilus  strain AQ717+TX,  Bacillus pumilus  strain QST 2808 (Sonata®+TX, Ballad Plus®)+TX,  Bacillus spahericus  (VectoLex®)+TX,  Bacillus  spp.+TX,  Bacillus  spp. strain AQ175+TX,  Bacillus  spp. strain AQ177+TX,  Bacillus  spp. strain AQ178+TX,  Bacillus subtilis  strain QST 713 (CEASE®+TX, Serenade®+TX, Rhapsody®)+TX,  Bacillus subtilis  strain QST 714 (JAZZ®)+TX,  Bacillus subtilis  strain AQ153+TX,  Bacillus subtilis  strain AQ743+TX,  Bacillus subtilis  strain QST3002+TX,  Bacillus subtilis  strain QST3004+TX,  Bacillus subtilis  var.  amyloliquefaciens  strain FZB24 (Taegro®+TX, Rhizopro®)+TX,  Bacillus thuringiensis  Cry 2Ae+TX,  Bacillus thuringiensis  Cry1 Ab+TX,  Bacillus thuringiensis aizawai  GC 91 (Agree®)+TX,  Bacillus thuringiensis israelensis  (BMP123®+TX, Aquabac®+TX, VectoBac®)+TX,  Bacillus thuringiensis kurstaki  (Javelin®+TX, Deliver®+TX, CryMax®+TX, Bonide®+TX, Scutella WP®+TX, Turilav WP®+TX, Astuto®+TX, Dipel WP®+TX, Biobit®+TX, Foray®)+TX,  Bacillus thuringiensis kurstaki  BMP 123 (Baritone®)+TX,  Bacillus thuringiensis kurstaki  HD-1 (Bioprotec-CAF/3P®)+TX,  Bacillus thuringiensis  strain BD #32+TX,  Bacillus thuringiensis  strain AQ52+TX,  Bacillus thuringiensis  var.  aizawai  (XenTari®+TX, DiPel®)+TX, bacteria spp. (GROWMEND@+TX, GROWSWEET®+TX, Shootup®)+TX, bacteriophage of Clavipacter  michiganensis  (AgriPhage®)+TX, Bakflor®+TX,  Beauveria bassiana  (Beaugenic®+TX, Brocaril WP®)+TX,  Beauveria bassiana  GHA (Mycotrol ES®+TX, Mycotrol O®+TX, BotaniGuard®)+TX,  Beauveria brongniartii  (Engerlingspilz®+TX, Schweizer  Beauveria ®+TX, Melocont®)+TX,  Beauveria  spp.+TX,  Botrytis cineria +TX,  Bradyrhizobium japonicum  (TerraMax®)+TX,  Brevibacillus brevis +TX,  Bacillus thuringiensis tenebrionis  (Novodor®)+TX, BtBooster+TX,  Burkholderia cepacia  (Deny®+TX, Intercept®+TX, Blue Circle®)+TX,  Burkholderia gladii +TX,  Burkholderia gladioli +TX,  Burkholderia  spp.+TX, Canadian thistle fungus (CBH Canadian Bioherbicide®)+TX,  Candida  butyri+TX,  Candida famata +TX,  Candida fructus +TX,  Candida glabrata +TX,  Candida guilliermondii +TX,  Candida melibiosica +TX,  Candida oleophila  strain O+TX,  Candida parapsilosis +TX,  Candida pelliculosa +TX,  Candida pulcherrima +TX,  Candida reukaufii +TX,  Candida saitoana  (Bio-Coat®+TX, Biocure®)+TX,  Candida sake +TX,  Candida  spp.+TX,  Candida tenius +TX,  Cedecea dravisae +TX,  Cellulomonas flavigena +TX,  Chaetomium cochliodes  (Nova-Cide®)+TX,  Chaetomium globosum  (Nova-Cide®)+TX,  Chromobacterium subtsugae  strain PRAA4-1T (Grandevo®)+TX,  Cladosporium cladosporioides +TX,  Cladosporium oxysporum +TX,  Cladosporium chlorocephalum +TX,  Cladosporium  spp.+TX,  Cladosporium tenuissimum +TX,  Clonostachys rosea  (EndoFine®)+TX,  Colletotrichum acutatum +TX,  Coniothyrium minitans  (Cotans WG®)+TX,  Coniothyrium  spp.+TX,  Cryptococcus albidus  (YIELDPLUS®)+TX,  Cryptococcus humicola +TX,  Cryptococcus infirmominiatus +TX,  Cryptococcus laurentii +TX,  Cryptophlebia leucotreta granulovirus  (Cryptex®)+TX,  Cupriavidus campinensis +TX,  Cydia pomonella granulovirus  (CYD-X®)+TX,  Cydia pomonella granulovirus  (Madex®+TX, Madex Plus®+TX, Madex Max/Carpovirusine®)+TX,  Cylindrobasidium laeve  (Stumpout®)+TX, Cylindrocladium+TX,  Debaryomyces hansenii +TX,  Drechslera hawaiinensis +TX,  Enterobacter cloacae +TX,  Enterobacteriaceae +TX,  Entomophtora virulenta  (Vektor®)+TX,  Epicoccum nigrum +TX,  Epicoccum purpurascens +TX,  Epicoccum  spp.+TX,  Filobasidium floriforme +TX,  Fusarium acuminatum +TX,  Fusarium chlamydosporum +TX,  Fusarium oxysporum  (Fusaclean®/Biofox C®)+TX,  Fusarium proliferatum +TX,  Fusarium  spp.+TX,  Galactomyces geotrichum +TX,  Gliocladium catenulatum  (Primastop®+TX, Prestop®)+TX,  Gliocladium roseum +TX,  Gliocladium  spp. (SoilGard®)+TX,  Gliocladium virens  (Soilgard®)+TX,  Granulovirus  (Granupom®)+TX,  Halobacillus halophilus +TX,  Halobacillus litoralis +TX,  Halobacillus trueperi +TX,  Halomonas  spp.+TX,  Halomonas subglaciescola +TX,  Halovibrio variabilis +TX,  Hanseniaspora uvarum +TX,  Helicoverpa armigera  nucleopolyhedrovirus (Helicovex®)+TX,  Helicoverpa zea  nuclear polyhedrosis virus (Gemstar®)+TX, Isoflavone- formononetin  (Myconate®)+TX,  Kloeckera apiculata +TX,  Kloeckera  spp.+TX,  Lagenidium giganteum  (Laginex®)+TX,  Lecanicillium longisporum  (Vertiblast®)+TX,  Lecanicillium muscarium  (Vertikil®)+TX,  Lymantria dispar  nucleopolyhedrosis virus (Disparvirus®)+TX,  Marinococcus halophilus +TX,  Meira geulakonigii +TX,  Metarhizium anisopliae  (Met52®)+TX,  Metarhizium anisopliae  (Destruxin WP®)+TX,  Metschnikowia fruticola  (Shemer®)+TX,  Metschnikowia pulcherrima +TX,  Microdochium dimerum  (Antibot®)+TX,  Micromonospora coerulea +TX,  Microsphaeropsis ochracea +TX,  Muscodor albus  620 (Muscudor®)+TX,  Muscodor roseus  strain A3-5+TX,  Mycorrhizae  spp. (AMykor®+TX, Root Maximizer®)+TX,  Myrothecium verrucaria  strain AARC-0255 (DiTera®)+TX, BROS PLUS®+TX,  Ophiostoma piliferum  strain D97 (Sylvanex®)+TX,  Paecilomyces farinosus +TX,  Paecilomyces fumosoroseus  (PFR-97®+TX, PreFeRal®)+TX,  Paecilomyces linacinus  (Biostat WP®)+TX,  Paecilomyces lilacinus  strain 251 (MeloCon WG®)+TX,  Paenibacillus polymyxa +TX,  Pantoea agglomerans  (BlightBan C 9 -1®)+TX,  Pantoea  spp.+TX,  Pasteuria  spp. (Econem®)+TX,  Pasteuria nishizawae +TX,  Penicillium aurantiogriseum +TX,  Penicillium billai  (Jumpstart®+TX, TagTeam®)+TX,  Penicillium brevicompactum +TX,  Penicillium frequentans +TX,  Penicillium griseofulvum +TX,  Penicillium purpurogenum +TX,  Penicillium  spp.+TX,  Penicillium viridicatum +TX,  Phlebiopsis gigantean  (Rotstop®)+TX, phosphate solubilizing bacteria (Phosphomeal®)+TX,  Phytophthora cryptogea +TX,  Phytophthora palmivora  (Devine®)+TX,  Pichia anomala +TX,  Pichia guilermondii +TX,  Pichia membranaefaciens +TX,  Pichia onychis +TX,  Pichia stipites +TX,  Pseudomonas aeruginosa +TX,  Pseudomonas aureofasciens  (Spot-Less Biofungicide®)+TX,  Pseudomonas cepacia +TX,  Pseudomonas chlororaphis  (AtEze®)+TX,  Pseudomonas corrugate +TX,  Pseudomonas fluorescens  strain A506 (BlightBan A506®)+TX,  Pseudomonas putida +TX,  Pseudomonas reactans +TX,  Pseudomonas  spp.+TX,  Pseudomonas syringae  (Bio-Save®)+TX,  Pseudomonas viridiflava +TX,  Pseudomons fluorescens  (Zequanox®)+TX,  Pseudozyma flocculosa  strain PF-A22 UL (Sporodex L®)+TX,  Puccinia canaliculata +TX,  Puccinia thlaspeos  (Wood Warrior®)+TX,  Pythium paroecandrum +TX,  Pythium oligandrum  (Polygandron®+TX, Polyversum®)+TX,  Pythium periplocum +TX,  Rhanella aquatilis +TX,  Rhanella  spp.+TX,  Rhizobia  (Dormal®+TX, Vault®)+TX,  Rhizoctonia +TX,  Rhodococcus globerulus  strain AQ719+TX,  Rhodosporidium diobovatum +TX,  Rhodosporidium toruloides +TX,  Rhodotorula  spp.+TX,  Rhodotorula glutinis +TX,  Rhodotorula graminis +TX,  Rhodotorula mucilagnosa +TX,  Rhodotorula rubra +TX,  Saccharomyces cerevisiae +TX,  Salinococcus roseus +TX,  Sclerotinia minor +TX,  Sclerotinia minor  (SARRITOR®)+TX,  Scytalidium  spp.+TX,  Scytalidium uredinicola +TX,  Spodoptera exigua  nuclear polyhedrosis virus (Spod-X®+TX, Spexit®)+TX,  Serratia marcescens +TX,  Serratia plymuthica +TX,  Serratia  spp.+TX,  Sordaria fimicola +TX,  Spodoptera littoralis  nucleopolyhedrovirus (Littovir®)+TX,  Sporobolomyces roseus +TX,  Stenotrophomonas maltophilia +TX,  Streptomyces ahygroscopicus +TX,  Streptomyces albaduncus +TX,  Streptomyces exfoliates +TX,  Streptomyces galbus +TX,  Streptomyces griseoplanus +TX,  Streptomyces griseoviridis  (Mycostop®)+TX,  Streptomyces lydicus  (Actinovate®)+TX,  Streptomyces lydicus  WYEC-108 (ActinoGrow®)+TX,  Streptomyces violaceus +TX,  Tilletiopsis minor +TX,  Tilletiopsis  spp.+TX,  Trichoderma asperellum  (T34 Biocontrol®)+TX,  Trichoderma gamsii  (Tenet®)+TX,  Trichoderma atroviride  (Plantmate®)+TX,  Trichoderma hamatum  TH 382+TX,  Trichoderma harzianum rifai  (Mycostar®)+TX,  Trichoderma harzianum  T-22 (Trianum-P®+TX, PlantShield HCO+TX, RootShield®+TX, Trianum-G®)+TX,  Trichoderma harzianum  T-39 (Trichodex®)+TX,  Trichoderma inhamatum +TX,  Trichoderma koningii +TX,  Trichoderma  spp. LC 52 (Sentinel®)+TX,  Trichoderma lignorum +TX,  Trichoderma longibrachiatum +TX,  Trichoderma polysporum  (Binab T®)+TX,  Trichoderma taxi +TX,  Trichoderma virens +TX,  Trichoderma virens  (formerly  Gliocladium virens  GL-21) (SoilGuard®)+TX,  Trichoderma viride +TX,  Trichoderma viride  strain ICC 080 (Remedier®)+TX,  Trichosporon pullulans +TX,  Trichosporon  spp.+TX,  Trichothecium  spp.+TX,  Trichothecium roseum +TX,  Typhula phacorrhiza  strain 94670+TX,  Typhula phacorrhiza  strain 94671+TX,  Ulocladium atrum +TX,  Ulocladium oudemansii  (Botry-Zen®)+TX,  Ustilago maydis +TX, various bacteria and supplementary micronutrients (Natural II®)+TX, various fungi (Millennium Microbes®)+TX,  Verticillium chlamydosporium +TX,  Verticillium lecanii  (Mycotal®+TX, Vertalec®)+TX, Vip3Aa20 (VIPtera®)+TX,  Virgibaclillus marismortui +TX,  Xanthomonas campestris  pv.  Poae  (Camperico®)+TX,  Xenorhabdus bovienii +TX,  Xenorhabdus nematophilus;    
     Plant extracts including: pine oil (Retenol®)+TX, azadirachtin (Plasma Neem Oil®+TX, AzaGuard®+TX, MeemAzal®+TX, Molt-X®+TX, Botanical IGR (Neemazad®+TX, Neemix®)+TX, canola oil (Lilly Miller Vegol®)+TX,  Chenopodium ambrosioides  near  ambrosioides  (Requiem®)+TX,  Chrysanthemum  extract (Crisant®)+TX, extract of neem oil (Trilogy®)+TX, essentials oils of  Labiatae  (Botania®)+TX, extracts of clove rosemary peppermint and thyme oil (Garden insect killer®)+TX, Glycinebetaine (Greenstim®)+TX, garlic+TX, lemongrass oil (GreenMatch®)+TX, neem oil+TX,  Nepeta cataria  (Catnip oil)+TX,  Nepeta catarina +TX, nicotine+TX, oregano oil (MossBuster®)+TX,  Pedaliaceae  oil (Nematon®)+TX,  pyrethrum +TX,  Quillaja saponaria  (NemaQ®)+TX,  Reynoutria sachalinensis  (Regalia®+TX, Sakalia®)+TX, rotenone (Eco Roten®)+TX, Rutaceae plant extract (Soleo®)+TX, soybean oil (Ortho ecosense®)+TX, tea tree oil (Timorex Gold®)+TX, thymus oil+TX, AGNIQUE® MMF+TX, BugOil®+TX, mixture of rosemary sesame pepermint thyme and cinnamon extracts (EF 300®)+TX, mixture of clove rosemary and peppermint extract (EF 400®)+TX, mixture of clove peppermint garlic oil and mint (Soil Shot®)+TX, kaolin (Screen®)+TX, storage glucam of brown algae (Laminarin®); 
     pheromones including: blackheaded fireworm pheromone (3M Sprayable Blackheaded Fireworm Pheromone®)+TX, Codling Moth Pheromone (Paramount dispenser-(CM)/Isomate C-Plus®)+TX, Grape Berry Moth Pheromone (3M MEC-GBM Sprayable Pheromone®)+TX, Leafroller pheromone (3M MEC—LR Sprayable Pheromone®)+TX, Muscamone (Snip7 Fly Bait®+TX, Starbar Premium Fly Bait®)+TX, Oriental Fruit Moth Pheromone (3M oriental fruit moth sprayable Pheromone®)+TX, Peachtree Borer Pheromone (Isomate-P®)+TX, Tomato Pinworm Pheromone (3M Sprayable pheromone®)+TX, Entostat powder (extract from palm tree) (Exosex CM®)+TX, (E+TX,Z+TX,Z)-3+TX,8+TX,11 Tetradecatrienyl acetate+TX, (Z+TX,Z+TX,E)-7+TX,11+TX,13-Hexadecatrienal+TX, (E+TX,Z)-7+TX,9-Dodecadien-1-yl acetate+TX, 2-Methyl-1-butanol+TX, Calcium acetate+TX, Scenturion®+TX, Biolure®+TX, Check-Mate®+TX, Lavandulyl senecioate; Macrobials including:  Aphelinus abdominalis +TX,  Aphidius ervi  ( Aphelinus -System®)+TX,  Acerophagus papaya +TX,  Adalia bipunctata  (Adalia-System®)+TX,  Adalia bipunctata  (Adaline®)+TX,  Adalia bipunctata  (Aphidalia®)+TX,  Ageniaspis citricola +TX,  Ageniaspis fuscicollis +TX,  Amblyseius andersoni  (Anderline®+TX  andersoni -System®)+TX,  Amblyseius californicus  (Amblyline®+TX, Spical®)+TX,  Amblyseius cucumeris  (Thripex®+TX, Bugline  cucumeris ®)+TX,  Amblyseius fallacis  (Fallacis®)+TX,  Amblyseius swirskii  (Bugline swirskii®+TX, Swirskii-Mite®)+TX,  Amblyseius womersleyi  (WomerMite®)+TX,  Amitus hesperidum +TX,  Anagrus atomus +TX,  Anagyrus fusciventris +TX,  Anagyrus kamali +TX,  Anagyrus loecki +TX,  Anagyrus pseudococci  (Citripar®)+TX,  Anicetus benefices +TX,  Anisopteromalus calandrae +TX,  Anthocoris nemoralis  (Anthocoris-System®)+TX,  Aphelinus abdominalis  (Apheline®+TX, Aphiline®)+TX,  Aphelinus asychis +TX,  Aphidius colemani  (Aphipar®)+TX,  Aphidius ervi  (Ervipar®)+TX,  Aphidius gifuensis +TX,  Aphidius matricariae  (Aphipar-M®)+TX,  Aphidoletes aphidimyza  (Aphidend®)+TX,  Aphidoletes aphidimyza  (Aphidoline®)+TX,  Aphytis lingnanensis +TX,  Aphytis melinus +TX,  Aprostocetus hagenowii +TX,  Atheta coriaria  (Staphyline®)+TX,  Bombus  spp.+TX,  Bombus terrestris  (Natupol Beehive®)+TX,  Bombus terrestris  (Beeline®+TX, Tripol®)+TX,  Cephalonomia stephanoderis +TX,  Chilocorus nigritus +TX,  Chrysoperla carnea  (Chrysoline®)+TX,  Chrysoperla carnea  (Chrysopa®)+TX,  Chrysoperla rufilabris +TX,  Cirrospilus ingenuus +TX,  Cirrospilus quadristriatus +TX,  Citrostichus phyllocnistoides +TX,  Closterocerus chamaeleon +TX,  Closterocerus  spp.+TX,  Coccidoxenoides perminutus  (Planopar®)+TX,  Coccophagus cowperi +TX,  Coccophagus lycimnia +TX,  Cotesia flavipes +TX,  Cotesia plutellae +TX,  Cryptolaemus montrouzieri  (Cryptobug®+TX, Cryptoline®)+TX,  Cybocephalus nipponicus +TX,  Dacnusa sibirica +TX,  Dacnusa sibirica  (Minusa®)+TX,  Diglyphus isaea  (Diminex®)+TX,  Delphastus catalinae  (Delphastus®)+TX,  Delphastus pusillus +TX,  Diachasmimorpha krausii +TX,  Diachasmimorpha longicaudata +TX,  Diaparsis jucunda +TX,  Diaphorencyrtus aligarhensis +TX,  Diglyphus isaea +TX,  Diglyphus isaea  (Miglyphus®+TX, Digline®)+TX,  Dacnusa sibirica  (DacDigline®+TX, Minex®)+TX,  Diversinervus  spp.+TX,  Encarsia citrina +TX,  Encarsia formosa  ( Encarsia  max®+TX, Encarline®+TX, En-Strip®)+TX,  Eretmocerus eremicus  (Enermix®)+TX,  Encarsia guadeloupae +TX,  Encarsia haitiensis +TX,  Episyrphus balteatus  (Syrphidend®)+TX,  Eretmoceris siphonini +TX,  Eretmocerus californicus +TX,  Eretmocerus eremicus  (Ercal®+TX, Eretline e®)+TX,  Eretmocerus eremicus  (Bemimix®)+TX,  Eretmocerus hayati +TX,  Eretmocerus mundus  (Bemipar®+TX, Eretline m®)+TX,  Eretmocerus siphonini +TX,  Exochomus quadripustulatus +TX,  Feltiella acarisuga  (Spidend®)+TX,  Feltiella acarisuga  (Feltiline®)+TX,  Fopius arisanus +TX,  Fopius ceratitivorus +TX,  Formononetin  (Wirless Beehome®)+TX,  Franklinothrips vespiformis  (Vespop®)+TX,  Galendromus occidentalis +TX,  Goniozus legneri +TX,  Habrobracon hebetor +TX,  Harmonia axyridis  (HarmoBeetle®)+TX,  Heterorhabditis  spp. (Lawn Patrol®)+TX,  Heterorhabditis bacteriophora  (NemaShield HB®+TX, Nemaseek®+TX, Terranem-Nam®+TX, Terranem®+TX, Larvanem®+TX, B-Green®+TX, NemAttack®+TX, Nematop®)+TX,  Heterorhabditis megidis  (Nemasys H®+TX, BioNem H®+TX, Exhibitline hm®+TX, Larvanem-M®)+TX,  Hippodamia convergens +TX,  Hypoaspis aculeifer  (Aculeifer-System®+TX, Entomite-A®)+TX,  Hypoaspis miles  (Hypoline m®+TX, Entomite-M®)+TX,  Lbalia leucospoides +TX,  Lecanoideus floccissimus +TX,  Lemophagus errabundus +TX,  Leptomastidea abnormis +TX,  Leptomastix dactylopii  (Leptopar®)+TX,  Leptomastix epona +TX,  Lindorus lophanthae +TX,  Lipolexis oregmae +TX,  Lucilia caesar  (Natufly®)+TX,  Lysiphlebus testaceipes +TX,  Macrolophus caliginosus  (Mirical-N®+TX, Macroline c®+TX, Mirical®)+TX,  Mesoseiulus longipes +TX,  Metaphycus flavus +TX,  Metaphycus lounsburyi +TX,  Micromus angulatus  (Milacewing®)+TX,  Microterys flavus +TX,  Muscidifurax raptorellus  and  Spalangia cameroni  (Biopar®)+TX,  Neodryinus typhlocybae +TX,  Neoseiulus californicus +TX,  Neoseiulus cucumeris  (THRYPEX®)+TX,  Neoseiulus fallacis +TX,  Nesideocoris tenuis  (NesidioBug®+TX, Nesibug®)+TX,  Ophyra aenescens  (Biofly®)+TX,  Orius insidiosus  (Thripor-I@+TX, Oriline i®)+TX,  Orius laevigatus  (Thripor-L®+TX, Oriline I®)+TX,  Orius majusculus  (Oriline m®)+TX,  Orius strigicollis  (Thripor-S®)+TX,  Pauesia juniperorum +TX,  Pediobius foveolatus +TX,  Phasmarhabditis hermaphrodita  (Nemaslug®)+TX,  Phymastichus coffea +TX,  Phytoseiulus macropilus +TX,  Phytoseiulus persimilis  (Spidex®+TX, Phytoline p®)+TX,  Podisus maculiventris  (Podisus®)+TX,  Pseudacteon curvatus +TX,  Pseudacteon obtusus +TX,  Pseudacteon tricuspis +TX,  Pseudaphycus maculipennis +TX,  Pseudleptomastix mexicana +TX,  Psyllaephagus pilosus +TX,  Psyttalia concolor  (complex)+TX,  Quadrastichus  spp.+TX,  Rhyzobius lophanthae +TX,  Rodolia cardinalis +TX,  Rumina decollate +TX,  Semielacher petiolatus +TX,  Sitobion avenae  (Ervibank®)+TX,  Steinernema carpocapsae  (Nematac C®+TX, Millenium®+TX, BioNem C®+TX, NemAttack@+TX, Nemastar®+TX, Capsanem®)+TX,  Steinernema feltiae  (NemaShield®+TX, Nemasys F®+TX, BioNem F®+TX,  Steinernema -System®+TX, NemAttack®+TX, Nemaplus®+TX, Exhibitline sf®+TX, Scia-rid®+TX, Entonem®)+TX,  Steinernema kraussei  (Nemasys L®+TX, BioNem L®+TX, Exhibitline srb®)+TX,  Steinernema riobrave  (BioVector®+TX, BioVektor®)+TX,  Steinernema scapterisci  (Nematac S®)+TX,  Steinernema  spp.+TX,  Steinernematid  spp. (Guardian Nematodes®)+TX,  Stethorus punctillum  (Stethorus®)+TX,  Tamarixia radiate +TX,  Tetrastichus setifer +TX,  Thripobius semiluteus +TX,  Torymus sinensis +TX,  Trichogramma brassicae  (Tricholine b®)+TX,  Trichogramma brassicae  (Tricho-Strip®)+TX,  Trichogramma evanescens +TX,  Trichogramma minutum +TX,  Trichogramma ostriniae +TX,  Trichogramma platneri +TX,  Trichogramma pretiosum +TX,  Xanthopimpla stemmator;    
     other biologicals including: abscisic acid+TX, bioSea®+TX,  Chondrostereum purpureum  (Chontrol Paste®)+TX,  Colletotrichum gloeosporioides  (Collego®)+TX,  Copper Octanoate  (Cueva®)+TX, Delta traps (Trapline d®)+TX,  Erwinia amylovora  (Harpin) (ProAct®+TX, Ni-HIBIT Gold CST®)+TX, Ferri-phosphate (Ferramol®)+TX, Funnel traps (Trapline y®)+TX, Gallex®+TX, Grower&#39;s Secret®+TX, Homo-brassonolide+TX, Iron Phosphate (Lilly Miller Worry Free Ferramol Slug &amp; Snail Bait®)+TX, MCP hail trap (Trapline f®)+TX,  Microctonus hyperodae +TX,  Mycoleptodiscus terrestris  (Des-X®)+TX, BioGain®+TX, Aminomite®+TX, Zenox®+TX, Pheromone trap (Thripline ams®)+TX, potassium bicarbonate (MilStop®)+TX, potassium salts of fatty acids (Sanova®)+TX, potassium silicate solution (Sil-Matrix®)+TX, potassium iodide+potassiumthiocyanate (Enzicur®)+TX, SuffOil-X®+TX, Spider venom+TX,  Nosema locustae  (Semaspore Organic Grasshopper Control®)+TX, Sticky traps (Trapline YF®+TX, Rebell Amarillo®)+TX and Traps (Takitrapline y+b®)+TX; and a safener, such as benoxacor+TX, cloquintocet (including cloquintocet-mexyl)+TX, cyprosulfamide+TX, dichlormid+TX, fenchlorazole (including fenchlorazole-ethyl)+TX, fenclorim+TX, fluxofenim+TX, furilazole+TX, isoxadifen (including isoxadifen-ethyl)+TX, mefenpyr (including mefenpyr-diethyl)+TX, metcamifen+TX and oxabetrinil+TX. 
     The references in brackets behind the active ingredients, e.g. [3878-19-1] refer to the Chemical Abstracts Registry number. The above described mixing partners are known. Where the active ingredients are included in “The Pesticide Manual” [The Pesticide Manual—A World Compendium; Thirteenth Edition; Editor: C. D. S. TomLin; The British Crop Protection Council], they are described therein under the entry number given in round brackets hereinabove for the particular compound; for example, the compound “abamectin” is described under entry number (1). Where “[CCN]” is added hereinabove to the particular compound, the compound in question is included in the “Compendium of Pesticide Common Names”, which is accessible on the internet [A. Wood; Compendium of Pesticide Common Names, Copyright © 1995-2004]; for example, the compound “acetoprole” is described under the internet address http://www.alanwood.net/pesticides/acetoprole.html. 
     Most of the active ingredients described above are referred to hereinabove by a so-called “common name”, the relevant “ISO common name” or another “common name” being used in individual cases. If the designation is not a “common name”, the nature of the designation used instead is given in round brackets for the particular compound; in that case, the IUPAC name, the IUPAC/Chemical Abstracts name, a “chemical name”, a “traditional name”, a “compound name” or a “development code” is used or, if neither one of those designations nor a “common name” is used, an “alternative name” is employed. “CAS Reg. No” means the Chemical Abstracts Registry Number. 
     The active ingredient mixture of the compounds of formula (I) selected from the compounds defined in the Tables 1 to 35 and Table P1 to P8 with active ingredients described above comprises a compound selected from one compound defined in the Tables 1 to 35 and Table P1 to P8 and an active ingredient as described above preferably in a mixing ratio of from 100:1 to 1:6000, especially from 50:1 to 1:50, more especially in a ratio of from 20:1 to 1:20, even more especially from 10:1 to 1:10, very especially from 5:1 and 1:5, special preference being given to a ratio of from 2:1 to 1:2, and a ratio of from 4:1 to 2:1 being likewise preferred, above all in a ratio of 1:1, or 5:1, or 5:2, or 5:3, or 5:4, or 4:1, or 4:2, or 4:3, or 3:1, or 3:2, or 2:1, or 1:5, or 2:5, or 3:5, or 4:5, or 1:4, or 2:4, or 3:4, or 1:3, or 2:3, or 1:2, or 1:600, or 1:300, or 1:150, or 1:35, or 2:35, or 4:35, or 1:75, or 2:75, or 4:75, or 1:6000, or 1:3000, or 1:1500, or 1:350, or 2:350, or 4:350, or 1:750, or 2:750, or 4:750. Those mixing ratios are by weight. 
     The mixtures as described above can be used in a method for controlling pests, which comprises applying a composition comprising a mixture as described above to the pests or their environment, with the exception of a method for treatment of the human or animal body by surgery or therapy and diagnostic methods practised on the human or animal body. 
     The mixtures comprising a compound of formula (I) selected from the compounds defined in the Tables 1 to 35 and Table P1 to P8 and one or more active ingredients as described above can be applied, for example, in a single “ready-mix” form, in a combined spray mixture composed from separate formulations of the single active ingredient components, such as a “tank-mix”, and in a combined use of the single active ingredients when applied in a sequential manner, i.e. one after the other with a reasonably short period, such as a few hours or days. The order of applying the compounds of formula (I) and the active ingredients as described above is not essential for working the present invention. 
     The compositions according to the invention can also comprise further solid or liquid auxiliaries, such as stabilizers, for example unepoxidized or epoxidized vegetable oils (for example epoxidized coconut oil, rapeseed oil or soya oil), antifoams, for example silicone oil, preservatives, viscosity regulators, binders and/or tackifiers, fertilizers or other active ingredients for achieving specific effects, for example bactericides, fungicides, nematocides, plant activators, molluscicides or herbicides. 
     The compositions according to the invention are prepared in a manner known per se, in the absence of auxiliaries for example by grinding, screening and/or compressing a solid active ingredient and in the presence of at least one auxiliary for example by intimately mixing and/or grinding the active ingredient with the auxiliary (auxiliaries). These processes for the preparation of the compositions and the use of the compounds I for the preparation of these compositions are also a subject of the invention. 
     The application methods for the compositions, that is the methods of controlling pests of the abovementioned type, such as spraying, atomizing, dusting, brushing on, dressing, scattering or pouring—which are to be selected to suit the intended aims of the prevailing circumstances—and the use of the compositions for controlling pests of the abovementioned type are other subjects of the invention. Typical rates of concentration are between 0.1 and 1000 ppm, preferably between 0.1 and 500 ppm, of active ingredient. The rate of application per hectare is generally 1 to 2000 g of active ingredient per hectare, in particular 10 to 1000 g/ha, preferably 10 to 600 g/ha. 
     A preferred method of application in the field of crop protection is application to the foliage of the plants (foliar application), it being possible to select frequency and rate of application to match the danger of infestation with the pest in question. Alternatively, the active ingredient can reach the plants via the root system (systemic action), by drenching the locus of the plants with a liquid composition or by incorporating the active ingredient in solid form into the locus of the plants, for example into the soil, for example in the form of granules (soil application). In the case of paddy rice crops, such granules can be metered into the flooded paddy-field. 
     The compounds of formula (I) of the invention and compositions thereof are also be suitable for the protection of plant propagation material, for example seeds, such as fruit, tubers or kernels, or nursery plants, against pests of the abovementioned type. The propagation material can be treated with the compound prior to planting, for example seed can be treated prior to sowing. Alternatively, the compound can be applied to seed kernels (coating), either by soaking the kernels in a liquid composition or by applying a layer of a solid composition. It is also possible to apply the compositions when the propagation material is planted to the site of application, for example into the seed furrow during drilling. These treatment methods for plant propagation material and the plant propagation material thus treated are further subjects of the invention. Typical treatment rates would depend on the plant and pest/fungi to be controlled and are generally between 1 to 200 grams per 100 kg of seeds, preferably between 5 to 150 grams per 100 kg of seeds, such as between 10 to 100 grams per 100 kg of seeds. 
     The term seed embraces seeds and plant propagules of all kinds including but not limited to true seeds, seed pieces, suckers, corns, bulbs, fruit, tubers, grains, rhizomes, cuttings, cut shoots and the like and means in a preferred embodiment true seeds. 
     The present invention also comprises seeds coated or treated with or containing a compound of formula I. The term “coated or treated with and/or containing” generally signifies that the active ingredient is for the most part on the surface of the seed at the time of application, although a greater or lesser part of the ingredient may penetrate into the seed material, depending on the method of application. When the said seed product is (re)planted, it may absorb the active ingredient. In an embodiment, the present invention makes available a plant propagation material adhered thereto with a compound of formula I. Further, it is hereby made available, a composition comprising a plant propagation material treated with a compound of formula I. 
     Seed treatment comprises all suitable seed treatment techniques known in the art, such as seed dressing, seed coating, seed dusting, seed soaking and seed pelleting. The seed treatment application of the compound formula (I) can be carried out by any known methods, such as spraying or by dusting the seeds before sowing or during the sowing/planting of the seeds. 
     The compounds of the invention can be distinguished from other similar compounds by virtue of greater efficacy at low application rates and/or different pest control, which can be verified by the person skilled in the art using the experimental procedures, using lower concentrations if necessary, for example 10 ppm, 5 ppm, 2 ppm, 1 ppm or 0.2 ppm; or lower application rates, such as 300, 200 or 100, mg of Al per m 2 . The greater efficacy can be observed by an increased safety profile (against non-target organisms above and below ground (such as fish, birds and bees), improved physico-chemical properties, or increased biodegradability). 
     In each aspect and embodiment of the invention, “consisting essentially” and inflections thereof are a preferred embodiment of “comprising” and its inflections, and “consisting of” and inflections thereof are a preferred embodiment of “consisting essentially of” and its inflections. 
     The disclosure in the present application makes available each and every combination of embodiments disclosed herein. 
     It should be noted that the disclosure herein in respect of a compound of formula I applies equally in respect of a compound of each of formulae Ia, Ib, and Tables 1 to 35. 
     BIOLOGICAL EXAMPLES 
     The Examples which follow serve to illustrate the invention. Certain compounds of the invention can be distinguished from known compounds by virtue of greater efficacy at low application rates, which can be verified by the person skilled in the art using the experimental procedures outlined in the Examples, using lower application rates if necessary, for example 50 ppm, 24 ppm, 12.5 ppm, 6 ppm, 3 ppm, 1.5 ppm, 0.8 ppm or 0.2 ppm. 
     Example B1:  Diabrotica balteata  (Corn Root Worm) 
     Maize sprouts placed onto an agar layer in 24-well microtiter plates were treated with aqueous test solutions prepared from 10′000 ppm DMSO stock solutions by spraying. After drying, the plates were infested with L2 larvae (6 to 10 per well). The samples were assessed for mortality and growth inhibition in comparison to untreated samples 4 days after infestation. 
     The following compounds gave an effect of at least 80% control in at least one of the two categories (mortality or growth inhibition) at an application rate of 200 ppm: P1.2, P2.1, P2.2, P2.5, P2-17, P3.4, P7.1, P8.1 
     Example B2:  Euschistus heros  (Neotropical Brown Stink Bug) 
     Soybean leaves on agar in 24-well microtiter plates were sprayed with aqueous test solutions prepared from 10′000 ppm DMSO stock solutions. After drying the leaves were infested with N2 nymphs. The samples were assessed for mortality and growth inhibition in comparison to untreated samples 5 days after infestation. 
     The following compounds gave an effect of at least 80% control in at least one of the two categories (mortality or growth inhibition) at an application rate of 200 ppm: P2.1., P8.1 
     Example B3:  Plutella xylostella  (Diamond Back Moth) 
     24-well microtiter plates with artificial diet were treated with aqueous test solutions prepared from 10′000 ppm DMSO stock solutions by pipetting. After drying,  Plutella  eggs were pipetted through a plastic stencil onto a gel blotting paper and the plate was closed with it. The samples were assessed for mortality and growth inhibition in comparison to untreated samples 8 days after infestation. The following compounds gave an effect of at least 80% control in at least one of the two categories (mortality or growth inhibition) at an application rate of 200 ppm: P1.2, P1.15, P1.51, P2.1, P2.2, P2.5, P2.10, P2.15, P2.16, P5.1, P5.2, P5.3, P7.1, P8.1 
     Example B4:  Myzus persicae  (Green Peach Aphid). Intrinsic Activity 
     Test compounds prepared from 10′000 ppm DMSO stock solutions were applied by pipette into 24-well microtiter plates and mixed with sucrose solution. The plates were closed with a stretched Parafilm. A plastic stencil with 24 holes was placed onto the plate and infested pea seedlings were placed directly on the Parafilm. The infested plate was closed with a gel blotting paper and another plastic stencil and then turned upside down. The samples were assessed for mortality 5 days after infestation. 
     The following compounds resulted in at least 80% mortality at a test rate of 12 ppm: P1.3, P1.4, P1.22, P1.26 
     Example B5:  Tetranychus urticae  (Two-Spotted Spider Mite): Feeding/Contact Activity 
     Bean leaf discs on agar in 24-well microtiter plates were sprayed with aqueous test solutions prepared from 10′000 ppm DMSO stock solutions. After drying the leaf discs were infested with a mite population of mixed ages. The samples were assessed for mortality on mixed population (mobile stages) 8 days after infestation. 
     The following compounds resulted in at least 80% mortality at an application rate of 200 ppm: P1.1, P1.2, P1.3, P1.4, P1.5, P1.6, P1.7, P1.8, P1.10, P1.11, P1.12, P1.13, P1.14, P1.15, P1.16, P1.17, P1.18, P1.19, P1.20, P1.21, P1.22, P1.23, P1.24, P1.25, P1.26, P1.27, P1.28, P1.29, P1.30, P1.31, P1.33, P1.34, P1.35, P1.36, P1.37, P1.39, P1.40, P1.41, P1.42, P1.43, P1.44, P1.45, P1.46, P1.49, P1.50, P1.52, P2.1, P2.2, P2.3, P2.4, P2.5, P2.6, P2.7, P2.8, P2.9, P2.10, P2.11, P2.12, P2.13, P2.17, P3.1, P3.2, P3.3, P3.4, P3.5, P3.6, P3.7, P3.8, P3.9, P4.1, P4.2, P5.2, P6.1, P7.1., P8.1