Patent Publication Number: US-2013251730-A1

Title: Compounds and Mixtures Influencing Inflammatory States

Description:
BACKGROUND OF THE INVENTION 
     1. Field of Invention 
     The present invention belongs to the area pharmaceutical and cosmetic compositions and refers to novel compounds, mixtures and preparations comprising new compounds with excellent anti-inflammatory properties. 
     2. State of the Art 
     There is a constant need to provide inflammation-inhibiting substances for the protection of cells or tissues (of people and animals), in particular of the skin, above all for use in cosmetic preparations, pharmaceutical preparations, foodstuffs or semi-luxury products. In particular there is a constant need to find new substances with anti-inflammatory activity, which support the natural defence mechanisms against inflammation in physiological systems (of people and animals). In this respect, there is particularly great interest in substances from natural extracts. Particularly attractive for use in foods are plants or parts or extracts of plants, which have a long history of edible consumption. 
     In the context of the present text, the term “skin” comprises not only the (human or animal) skin in the usual sense, but rather cell layers in general which cover internal and/or external surfaces on/in the human or animal body. Accordingly, in the context of the present text, the term “skin” comprises surface and glandular epithelia, i.e. in particular also mucous membranes, e.g. the oral mucosa, the gastric mucosa and the intestinal mucosa. As barrier organs of the (human) body, the mucous membranes are exposed to external influences to a particular extent. They line the various body cavities which are either in contact with the external environment (e.g. mouth and throat) or the internal organs of a body (e.g. intestinal lumen). 
     Many intrinsic factors (e.g. genetic predisposition) and extrinsic factors (e.g. damage to the skin barrier, influence of UV light, skin-irritant or allergy-triggering substances) can lead to skin irritation or dysfunctions of the skin. 
     In the context of the present text “skin irritation” is understood to mean any change in the skin, which triggers indisposition (“sensorial malaise”), and/or is characterized by symptoms of dry, reddened and/or inflamed skin. The term “sensorial malaise” also includes states which are associated with pruritus or pains. 
     Skin irritation can include the following skin conditions: sensitive skin, for example sensitive scalp, easily damaged skin, atopic skin (atopy) and irritated or inflamed skin, which can appear in the form of skin reddening (erythema). 
     Skin irritation can in particular also concern or comprise
         irritation of the mucous membranes in the oral cavity, for example periodontitis and gingivitis (as described in detail below),   irritation and infections of the airways, for example rhinosinusitis (common cold), sinusitis and pharyngitis/tonsillitis, and   irritation of the gastrointestinal tract.       

     The problem of sensitive skin affects a growing number of adults and children. It is believed that a proportion of up to 50% of the population have sensitive skin (see L. Misery et al., Ann. Dermatol. Venereol. 2005, 132, 425-429). Sensitive skin describes skin which has a decreased threshold for irritant substances, and also hyper-reactive, intolerant and also atopic skin. In the case of people with sensitive or easily damaged skin, the so-called “stinging” (Engl. “to sting”=burn, stab, be painful) can be observed. Typical symptoms which are associated with “stinging” or “sensitive skin” in general are skin reddening, tingling, feelings of tension and burning of the skin and pruritus. They can be triggered by certain ambient influences, e.g. massage, influence of surfactants, weather (heat, cold, dryness or high atmospheric humidity), thermal or UV radiation (e.g. emanating from the sun) or even by psychological stress. 
     Sensitive scalp is also characterized by skin reddening, tingling, burning and stinging. Triggers are for example soap, shampoos or other hair care products, surfactants, water with a high calcium carbonate content and/or (mechanical) stress. Erythema and hyperseborrhoea (excessive sebaceous secretion) of the scalp and dandruff are often accompanied by the said symptoms. 
     Atopy (atopic syndrome) is observed (with a rising trend) in ca. 10-20% of the population in industrialized countries. This is a hypersensitivity of the skin to substances from the environment with an increased tendency to development of hypersensitivity reactions of the immediate type (allergies) towards substances from the natural environment. It is believed that atopy has genetic causes. Atopy can appear as atopic dermatitis. In this case, the skin barrier is damaged, and the skin is often inflamed and itches. 
     Periodontitis (as an example of an inflammatory reaction of the gums or the oral mucosa) is an inflammation of the periodontium (dental periosteum), i.e. the tissue which surrounds and supports the teeth. The periodontium consists of various tissues: gingival epithelium (gingiva; gum), connective tissue of the gingiva, dental periosteum (periodontium, desmodontium), dental cement and surrounding alveolar bone. The dental periosteum lies between the surface of the root and the alveolar bone and is a cell-rich connective tissue which holds the teeth in the osseous tooth socket, the alveolus. 53 to 74% of the periodontal gap consists of collagen and oxytalan fibre bundles. Periodontal fibres which are present in the dental cement and in the alveolar bone hold the tooth in the alveolar bone. The main characteristics of periodontitis comprise inflammation of the gum, loss of stability, formation of pockets in the dental periosteum and degradation of the alveolar bone. 
     The main cause of periodontitis is plaque. This consists of certain components of the saliva, food residues and bacteria and degradation products thereof. This specific form of infectious disease is in most cases caused by  Porphyromonas gingivalis, Bacteroides forsythus  and  Actinobacillus actinomycetemcomitans . The continuous release of bacterial toxins, in particular lipopolysaccharide (LPS), leads to a non-specific immune defence reaction. LPS-stimulated macrophages release prostaglandin E2 (PGE2) and pro-inflammatory mediators, such as for example interleukins (e.g. IL-1 beta) and TNF-alpha, in the affected tissue of the patient. The pro-inflammatory mediators trigger the release of further PGE2s and matrix-destroying metalloproteinases (matrix metalloproteinases, MMPs) from the invasive fibroblasts, which destroy the extracellular matrix of the surrounding connective tissue. This in turn allows bacteria which are actually in contact with the exposed gum to penetrate deeper into the underlying connective tissue and there to drive the inflammatory process further, so that eventually the junction between the top layer of the epithelium and the root is lost. As a result a pocket in the gum is formed. The body&#39;s reaction to this is an inflammation of the gum and the dental periosteum with damage to the alveolar bone. In the final stage of periodontitis, the person affected is at risk of tooth loss. 
     However, in addition to bacteria, chemical or mechanical damage can also cause irritation or inflammatory reactions of the gum or the oral mucosa. Pro-inflammatory mediators, in particular interleukins such as IL-1 alpha and PGE2, are released in this process. 
     Irritation and infections of the airways affect the respiratory tract (of people or animals). The respiratory tract is subdivided into three sections:
     (i) the upper airways, incl. nose and paranasal sinuses and pharynx,   (ii) the lower airways with larynx and trachea and   (iii) the lungs with bronchi, bronchioles, pulmonary alveoli, etc.   

     “Irritation and infections of the upper airways” designate in particular an acute infection, which affects the upper airways, nose, sinus, pharynx and/or larynx. In the United States of America, ca. one billion acute diseases of the upper airways are recorded each year. Irritation and infections of the upper airways include rhinosinusitis (common cold), sinusitis, pharyngitis/tonsillitis, laryngitis and sometimes bronchitis. The symptoms of these infections often include swelling of the nasal mucosae, cough, nasal catarrh, sore throat, fever, sneezing and pressure sensation. The symptoms as a rule start 1 to 3 days after contact with pathogenic germs, mostly viruses. The symptoms typically cease in 7 to 10 days, but can also persist for longer. 
     A commonly occurring (airway) infection is pharyngitis. Pharyngitis is in most cases a painful inflammation of the pharynx and is thus commonly also described as sore throat. Inflammation of the tonsils, tonsil inflammation or tonsillitis can arise at the same time. 
     For infections of the upper airways there are essentially three therapeutic approaches: symptomatic, remedial and preventive. Symptomatic therapy aims to alleviate symptoms and pain. Remedial therapies are intended to treat the pharyngitis by preventing its spreading and accelerate the healing process. Preventive therapy is intended to prevent the outbreak of an infection. 
     Remedial therapies are most effective against bacterial infections, e.g. streptococci. Many preventive therapies are also remedial. 
     With viral infections, the recovery from a pharyngeal inflammation as a rule occurs spontaneously within a few days. Hence the favourite method is symptomatic therapy. 
     Various non-antibiotic therapies for throat inflammation have been tested in controlled studies. Analgesic therapies are among the most effective here. 
     The symptomatic therapies for infections of the upper airways include: formulations whose purpose is to act remedially or symptomatically and which can present in the following forms:
         solid galenical forms (such as for example tablets (with and without coating, with and without modified release), sugar-coated tablets (with and without coating, with and without modified release), capsules (soft or hard gelatine capsules with and without modified release), granules (with and without modified release), powders (with and without modified release), suppositories (with and without coating, with and without modified release), lozenges and chewing gums),   liquid forms (such as for example solutions, suspensions, emulsions, syrups (colloquially cough syrup), mouthwashes, gargle solutions, throat sprays or nasal sprays, nasal drops, nasal rinse solutions, nasal powders, nasal ointments or ear drops, ear sprays, ear rinse solutions, ear powders and aural tampons),   semisolid forms (such as for example hydrophobic ointments including for example: hydrocarbon gels, lipogels, silicone gels, oleogels and water-absorbing ointments including for example absorption bases, hydrophilic ointments, hydrophilic gels (hydrogels) or pastes,   Inhalants (such as for example compressed gas dispenser inhalers, powder inhalers, inhalers with atomisers, and inhalation concentrates for inhalation), and   active substance-containing plasters or other therapeutic systems.       

     The gastrointestinal tract (also called digestive tract) is the system of internal organs which take up and digest the food, in order to absorb nutrient substances therefrom, to obtain energy and to excrete the food components remaining. Accordingly, the main functions of the digestive tract are food uptake, digestion, absorption and excretion. 
     The upper digestive tract consists of the mouth, pharynx, oesophagus and stomach. The mouth contains the oral mucosae, which contain the openings of the saliva glands, the tongue and the teeth. Behind the mouth lies the pharynx, which leads to a hollow muscular tube, the oesophagus, which in turn leads into the stomach. The small intestine is joined to the stomach. The lower digestive tract consists of the intestines and the anus. The intestines consist of the intestine, the small intestine, which consists of three parts, duodenum, jejunum and ileum, the large intestine, which also consists of three sections, caecum with vermiform appendix (blind gut), the colon (rising colon, transverse colon and descending colon) and the rectum. 
     The commonest inflammatory conditions of the digestive tracts include gastro-oesophageal reflux diseases, heartburn and gastric ulcers. The therapy usually includes firstly reduction of the symptoms and reduction of the inflammation in the tissue and secondly longer-term therapies in order to prevent reappearance of the symptoms. 
     Other inflammatory diseases of the digestive system, inter alia, are milder inflammatory diseases such as irritable bowel syndrome (IBS) and inflammatory diseases of unknown aetiology and chronic inflammatory intestinal diseases (IBD), such as for example chronic colitis (ulcerative colitis). 
     There is a particularly great need for suitable applications for the prevention or treatment of chronic inflammatory intestinal diseases, in particular chronic colitis (ulcerative colitis). 
     Chronic inflammation can appear as a cause of various diseases and living conditions. It can be associated with the most diverse conditions such as arthritis, some types of cancer, colitis, diabetes mellitus, coronary heart disease, obesity, Alzheimer&#39;s disease and immune dysfunction. 
     There are essentially two enzymatic pathways for regulating inflammation. The lipoxygenase pathway (5-LOX) results in the production of leukotrienes, which have a pro-inflammatory action. The second pathway is the cyclooxygenase pathway (COX-1 and COX-2). A high level of COX-2 indicates inflammation. Further inflammation markers are tumour necrosis factor (TNF-α), nuclear factor κB (NF-κB), interleukin-6 (IL-6), interleukin-17 (IL-17) and interleukin-1-β (IL1β). The enzymes, cytokines and metabolites thereof increase the production of prostaglandins and leukotrienes, which function as intercellular mediators, and are connected with the inflammatory process. Regulation of the enzymes LOX-5 and COX-2 in particular can have a positive effect in the development/suppression of inflammation. 
     A diet which is based on much sugar and starch, and fat and trans fatty acids, has a direct connection with chronic inflammation. Oxidation of multiply unsaturated fats and fatty acids in vitro and in vivo leads to the formation of reactive oxygen species (radicals), and to the form ation of nitrogen oxides. These compounds can initiate and/or promote the first phase of an inflammatory process. Damage to the DNA can result from this. 
     Over its whole length, particularly in the region of the intestine, the gastrointestinal tract is susceptible to inflammation, hence it is very important to inhibit corresponding processes and to prevent inflammation. Without treatment, harmful processes can lead to irritation, acute and chronic inflammation, and onwards to cancer. 
     Chronic inflammatory diseases of the digestive tract mucosa represent a considerable health political problem. Younger people in particular are falling ill, whose whole lifestyle is severely affected thereby, and who have to rely on medical care throughout their life. The aetiology/pathogenesis of the chronic inflammatory diseases of the digestive tract is not completely clear. However, it is believed to be a cause of the onset of a disorder of the intestinal barrier. 
     Ulcerative colitis and Crohn&#39;s disease are inflammations of the intestine, which exhibit characteristic accompanying symptoms such as diarrhoea, blood in stools, abdominal pains and cramps, and weight loss. At the same time, the intestinal mucosa appears red and swollen and often bleeds on the slightest touch. 
     The epithelial cells of the mucosa represent the cell layer closest to the surface. The intestinal epithelial cells constitute the greatest contact area of the body with the outside world. They absorb food and at the same time prevent the penetration of pathogenic organisms. The latter is promoted by chronic physiological inflammation. This is subject to a range of control and regulatory mechanisms in order to avoid on one hand the penetration of pathogenic germs and on the other hand damage due to the inflammatory mediators themselves. For this, the epithelial cells interact with the cells of the mucosa-associated immune system. 
     Intestinal epithelial cells possibly have an important role in the pathogenesis of chronic inflammatory intestinal diseases. The main model for the onset of chronic inflammatory intestinal diseases describes the following scenario: a defect in the structural integrity of the intestinal epithelium leads to an invasion of antigens from the intestinal lumen. In genetically predisposed patients, this process can trigger a chronic inflammation through activation of the mucosa-associated lymphatic tissue. A disorder of the cell-cell contact due to genetic modification of the N-adherin or keratin 8 triggers a chronic intestinal inflammation. Epithelial cells possess a large number of receptors for signal uptake. These in particular include receptors for the recognition of bacterial motifs, so-called pattern recognition receptors. 
     One such recognition receptor for bacterial motifs is the so-called NOD2/CARD15 protein. NOD2/CARD15 is a member of the NBS-LRR protein family (for nucleotide-binding site and leucine-rich repeat), the members whereof all play a part in the intracellular recognition of microbes and components thereof and which also include for example Apaf-1 and CARD4/NOD1, which possibly also can play a part in certain patients. When bacterial components bind to NOD2/CARD15, this normally leads to activation of the pro-inflammatory transcription factor NF-κB. 
     Adherent  E. coli  strains have been found in ulcerations in patients with Crohn&#39;s disease. In general, in patients with IBD or IBS, considerably more bacteria are directly adjacent to the intestinal epithelial cells than in the normal mucosa, which is protected from contact with bacteria by a mucus layer. This observation supports the hypothesis of the importance of bacterial translocation in the pathogenesis of IBD. 
     The currently available therapies for the treatment of Crohn&#39;s disease and ulcerative colitis can alleviate, but not cure, the disease symptoms. Most therapies end with a resistance to the antibiotic and surgical intervention. 
     In Biosci. BioTech. Biochem Japan, 67(9) S. 2038-2041 (2003) Makabe et al. showed that compound from  Myrsine sequinii , in particularly myrsonic acids have some anti-inflammatory properties. However, performance differed seriously between the various species and the document is silent with respect to the activity of the compounds in view of the broad range of different inflammation parameters. 
     JP 2007/077122 describes the use of plant proanthocyanidins, for example from apple, pear, apricot, grape, guava, hops, barley or adzuki bean for the prevention of intestinal inflammation, especially in the case of ulcerative colitis. The recommended daily intake is 100 to 2500 mg apple extract or corresponding quantities of apple proanthocyanidins. The effect of the apple proanthocyanidins was confirmed in mice with acute ulcerative colitis caused by dextran sulphate (DSS, 2.5%) over a period of 20 days. 
     Models of the DSS-induced colitis (acute or chronic) are rapid, simple to perform, well reproducible and inexpensive. They enable the real-time study of the inflammatory process from onset up to remission and are thus very suitable for studies of epithelial regeneration and wound healing and for drug screening. 
     The S3 Guideline “Diagnosis and Therapy of Crohn&#39;s disease” summarizes the results (on the treatment of the aforesaid diseases) of an evidence-based consensus conference of the German Society for Digestive and Metabolic Diseases with the competence field Chronic inflammatory intestinal diseases (Z Gastroenterol 2008; 46: 1094-1146). For the therapy of such diseases, inter alia budesonide, systemically active steroids, sulfasalazine, azathioprine/6-mercaptopurine, methotrexate and anti-TNF-alpha antibodies have until now been used. 
     Overall, however, there is still a need for suitable uses for the prophylaxis and/or treatment of inflammation. 
     SUMMARY OF THE INVENTION 
     Object of the present invention is a compound of the formula (X) 
     
       
         
         
             
             
         
       
     
     or any salt of a compound of the formula (X) or any mixture containing or consisting of two or more different compounds of the formula (X), two or more different salts of compounds of the formula (X) or one or more different compounds of the formula (X) and one or more different salts of compounds of the formula (X), wherein for
     R1, R2 and R3 independently of one another in every compound of the formula (X) the following applies:   R1 means hydrogen or methyl,   R2 means an organic residue with 5 carbon atoms and one oxygen atom or none and   R3 means an organic residue with 10 carbon atoms and one or more oxygen atoms,   or   R1 and R2 together with the carbon atoms in positions 4 and 5 and the oxygen atom bound to the carbon atom in position 4 form a ring and comprise 5 carbon atoms and one oxygen atom or none, and   R3 means an organic residue with 10 carbon atoms and one or more oxygen atoms,
 
for use in a method for the prophylaxis and/or treatment of inflammation, in particular of inflammation of the (human or animal) skin, in particular in a method
       for reducing the release of TNF-alpha, and/or   for reducing the release of an interleukin, preferably of IL-1, IL-6 and/or IL-8, and/or   for reducing the release of a prostaglandin, preferably of PGE2, and/or   for reducing the release of interferon-gamma and/or NF-κB,
 
particularly preferably in a method
   for reducing the release of TNF-alpha, and/or   for reducing the release of an interleukin, preferably of IL-1, IL-6 and/or IL-8, and/or   for reducing the release of a prostaglandin, preferably of PGE2.   
       

     Essentially therefore, the present invention relates to the aforementioned compounds, salts or mixtures thereof as anti-inflammatory active substances. 
     For the term “skin”, the aforesaid respectively applies. The skin to be treated according to the invention is thus preferably human or animal external skin (in the conventional sense) and/or a mucous membrane, in particular the oral mucosa, the gastric mucosa and/or the intestinal mucosa, in particular for the prophylaxis and/or treatment of one or more of the diseases or symptoms described above. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       The present invention will be explained in greater detail with reference to the accompanying drawings in which 
         FIGS. 1   a  and  1   b  are chromatograms of the invention according to Example 4, 
         FIG. 2   a  is a graph showing test results of the invention according to Example 1, 
         FIG. 2   b  is a graph showing test results of the invention according to Example 4, 
         FIG. 3   a  is a graph showing test results of the invention according to Example 1, 
         FIGS. 3   b  and  3   c  are graphs showing test results of the invention according to Example 4, 
         FIG. 3   d  is a graph showing test results of the invention according to Example 2, and 
         FIG. 3   e  is a graph showing test results of the invention according to Example 3. 
     
    
    
     DESCRIPTION OF THE PREFERRED EMBODIMENTS 
     Preferably the method for the prophylaxis and/or treatment of inflammation is
     (a) a method for the prophylaxis and/or treatment of chronic inflammatory diseases, in particular intestinal diseases,
 
and/or
   (b) a method for strengthening damaged or undamaged skin, in particular mucosa,
 
and/or
   (c) a method for reducing tissue damage, in particular tissue damage in the intestine,
 
and/or
   (d) a method for recreating a normal cellular composition in the intestine,
 
and/or
   (e) a method for recreating or stabilizing the function of skin, in particular of mucosa.   

     Preferred Compounds of Formula X 
     Particularly advantageous and therefore preferred according to the invention is a use as described above, wherein for the groups R1, R2 and R3 in the compound of the formula (X) or independently of one another in one, several or all, preferably all, compound(s) of the formula (X) the following applies:
     R3 means   

     
       
         
         
             
             
         
       
         
          wherein the dotted line which links the carbon atoms designated as B and C means that a single bond or a double bond is present between these carbon atoms, and 
          the dotted line which links the carbon atoms designated as E and G means an individual double bond, which is positioned either between the carbon atoms designated as F and G or between the carbon atoms designated as E and F, 
         R7, for the case where the double bond is positioned between the carbon atoms designated as E and F, means a hydroxy group or, for the case where the double bond is positioned between the carbon atoms designated as F and G, is absent, 
         R5 and R6 mean a hydrogen atom and a hydroxy group or together mean an oxygen atom, the dashed line marks the bond which links R3 with the carbon atom in position 3; 
         R1 means hydrogen or methyl and 
         R2 means 
       
    
     
       
         
         
             
             
         
       
         
          wherein R4 means hydrogen or a hydroxy group and the dashed line marks the bond which links R2 with the carbon atom in position 5 or 
         R1 and R2 together mean 
       
    
     
       
         
         
             
             
         
       
         
          wherein the dashed line (a) marks the bond which links the tertiary carbon atom with the oxygen atom bound to the carbon atom in position 4 and the dashed line (b) marks the bond which links the secondary carbon atom with the carbon atom in position 5. 
       
    
     Particularly preferable is a use according to the invention (as described above), wherein one, several or all compound(s) of the formula (X) is selected or are each selected independently of one another from the group consisting of the following compounds (1) to (10): 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
         
         Erionic acid A corresponds to: 4-hydroxy-3-((E)-7-hydroxy-3,7-dimethyl-4-oxo-oct-5-enyl)-5-((E)-4-hydroxy-3-methyl-but-2-enyl)-benzoic acid (1) 
         Erionic acid B corresponds to: 3-hydroxy-8-((E)-7-hydroxy-3,7-dimethyl-4-oxo-oct-5-enyl)-2,2-dimethyl-chroman-6-carboxylic acid (2) 
         Erionic acid C corresponds to: 3-(3,7-dimethyl-4-oxo-oct-6-enyl)-4-hydroxy-5-((E)-4-hydroxy-3-methyl-but-2-enyl)-benzoic acid (3) 
         Erionic acid D corresponds to: 8-((E)-3,7-dimethyl-4-oxo-oct-5-enyl)-3-hydroxy-2,2-dimethyl-chroman-6-carboxylic acid (4) 
         Erionic acid E corresponds to: 4-hydroxy-3-((E)-7-hydroxy-3,7-dimethyl-4-oxo-oct-5-enyl)-5-(3-methyl-but-2-enyl)-benzoic acid (5) 
         Erionic acid F corresponds to: 3-(3,7-dimethyl-4-oxo-oct-6-enyl)-4-hydroxy-5-(3-methyl-but-2-enyl)-benzoic acid (6) 
         Eriolic acid A corresponds to: 3-((E)-4-hydroxy-3,7-dimethyl-octa-2,6-dienyl)-5-((E)-4-hydroxy-3-methyl-but-2-enyl)-4-methoxy-benzoic acid (7) 
         Eriolic acid B corresponds to: 4-hydroxy-3-((E)-4-hydroxy-3,7-dimethyl-octa-2,6-dienyl)-5-(3-methyl-but-2-enyl)-benzoic acid (8) 
         Eriolic acid C corresponds to: 4-hydroxy-3-((E)-4-hydroxy-3,7-dimethyl-octa-2,6-dienyl)-5-((E)-4-hydroxy-3-methyl-but-2-enyl)-benzoic acid (9) and 
         Eriolic acid D corresponds to: 3-((E)-4-hydroxy-3,7-dimethyl-octa-2,6-dienyl)-4-methoxy-5-(3-methyl-but-2-enyl)-benzoic acid (10). 
       
    
     The benzoic acids of the formula (X) to be used according to the invention can contain one or more asymmetric carbon atoms. These can each be present in the (R) or (S) configuration. These stereoisomers can be present as enantiomers, diastereomers or epimers, in particular as (R), (S), (R,R), (R,S), (S,R) or (S,S)-configured compounds or as any mixture of these compounds, for example as a racemate, or also as any mixture of the corresponding diastereomers. 
     Particularly preferable according to the invention is a mixture (as described above), containing or consisting of two or more different compounds of the formula (X), preferably of two, three, four, five, six, seven, eight, nine or ten different compounds of the formula (X), preferably selected from the group consisting of the compounds (1) to (10). 
     Herba Santa 
     The aforementioned compounds (7) and (9) are two commercially available compounds (for example supplied by the firm Ambinter) identified in Herba Santa. However no references to an anti-inflammatory action of these compounds are known in the state of the art. It was particularly surprising that the compounds of the formula (X) from Herba Santa to be used according to the invention are particularly well suited for use as anti-inflammatory active substances. 
     Herba Santa (also Yerba Santa, mountain balm) in general designates  Eriodictyon  ssp., in particular  Eriodictyon californicum  (H. &amp; A.) Torr and  Eriodictyon angustifolium  (from the Hydrophyllaceae family). Herba Santa foliage has already long been used as a medicinal plant on account of its medicinal action. Traditionally, the plants, which were originally found in Mexico and the west of the USA, were used by American indigenous inhabitants and later by Spanish settlers (Heinsen, 1972; Munz, 1973; Barrett and Gifford, 1933; Immel, 2006). The antibacterial action of extracts from  Eriodictyon californicum  was described by Salle et al. in 1951 (Arch. Biochem. Biophys. 1951, 32, 121-123). The main substances contained in  Eriodictyon  sp. include various flavanones, inter alia homo-eriodictyol, hesperetin, sterubin, chrysoeriol and luteolin (Hadleyy and Gisvold, 1942; Ley et al., J. Agric. Food Chem., 2005). The different biological actions of Herba Santa were previously mainly attributed to the flavanones contained, the composition and structures whereof had already been studied. Scarcely anything is so far known in the literature concerning the properties of the components from Herba Santa which do not have a flavanoid structure. In particular, nothing is known concerning an antiinflammatory action of the compounds to be used according to the invention. The compounds (1) to (10) also occurring in various  Eriodictyon  sp. were only recently described for the first time. Their capabilities as antioxidants are presented in DE 10 2009 020729 A1. However, nothing was hitherto known concerning (additional) anti-inflammatory properties. 
     Hydroxyflavones 
     Particularly preferable according to the invention is a mixture for use in a method for the prophylaxis and/or treatment of inflammation (as described above), comprising a compound of the formula (X), a salt of the formula (X) or a mixture thereof (as respectively described above) and additionally
         a hydroxyflavone of the formula (Y)       

     
       
         
         
             
             
         
       
         
         
           
             or a salt of a hydroxyflavone of the formula (Y) 
             or a mixture containing or consisting of two or more different hydroxyflavones of the formula (Y), two or more different salts of hydroxyflavones of the formula (Y) or one or more different hydroxyflavones of the formula (Y) and one or more different salts of hydroxyflavones of the formula (Y),
 
wherein for Q1, Q2, Q3, Q4, Q5, Q6, Q7, Q8 and Q9 independently of one another in each hydroxyflavone of the formula (Y) the following applies:
 
Q1 to Q9 independently of one another mean hydrogen atoms, hydroxy groups, methyl, ethyl, 1-propyl, methoxy, ethoxy, 1-propyloxy or 2-propyloxy groups, with the proviso that at least one of the residues Q1 to Q9 represents a hydroxy group,
 
and wherein preferably the following applies:
 
Q2, Q4, Q5, Q8 and Q9 represent hydrogen atoms,
 
Q1, Q3 and Q6 independently of one another mean hydrogen atoms, hydroxy or methoxy groups, with the proviso that at least one of the residues Q1 and Q3 represents a hydroxy group,
 
and
 
Q7 represents a hydroxy group.
 
           
         
       
    
     The hydroxyflavones of the formula (Y) can be present as mono- or (in the case of several hydroxy groups) multivalent anions, wherein as counter-cations the singly positively charged cations of the first main and transition group, the ammonium ion, a trialkylammonium ion, the divalently charged cations of the second main and transition group, and the trivalent cations of the 3 rd  main and transition group, preferably, Na + , K + , NH 4   + , Ca 2+ , Al 3+  and Zn 2+ , are used. 
     The hydroxyflavones of the formula (Y) can be present as (2S) or (2R) enantiomers or as a mixture of both. Preferably the hydroxyflavones of the formula (Y) are present as the (2S) enantiomer or as a mixture enriched in (2S) enantiomer. 
     Without thereby limiting the invention, the following compounds may be mentioned by way of example: 2-(4-hydroxyphenyl)-5,7-dihydroxychroman-4-one (naringenin), 2-(3,4-dihydroxyphenyl)-5,7-di hydroxychroman-4-one (eriodictyol), 2-(3,4-di hydroxyphenyl)-5-hydroxy-7-methoxychroman-4-one (eriodictyol 7-methyl ether), 2-(3,4-dihydroxyphenyl)-7-hydroxy-5-methoxychroman-4-one (eriodictyol 5-methyl ether), 2-(4-hydroxy-3-methoxyphenyl)-5,7-dihydroxychroman-4-one (homoeriodictyol) and 2-(3-hydroxy-4-methoxyphenyl)-5,7-dihydroxychroman-4-one (hesperetin), (2S) or (2R) enantiomers thereof or mixtures thereof, and mono- or multivalent phenolate salts thereof with Na + , K + , NH 4   + , Ca 2+ , Mg 2+  or Al 3+  as counter-cations. 
     The structures of preferred examples of hydroxyflavones of the formula (Y) are shown below (see compounds (11) to (16)): 
     
       
         
         
             
             
         
       
     
     Particularly preferable is a mixture (as described above) comprising one, several or all compounds of the formula (Y) selected from the group consisting of homoeriodictyol, sterubin, eriodictyol, hesperetin, chrysoeriol and luteolin. 
     Particularly preferably, such a mixture contains at least homoeriodictyol as a compound of the formula (Y). 
     Mixtures 
     According to a preferable embodiment of the present invention, a mixture (as described above) is provided for the use, wherein
         the proportion of the total quantity of compounds of the formula (X) and salts of compounds of the formula (X) in the mixture, based on the total weight of the mixture, is 1 to 99 wt. %, preferably 10 to 99 wt. %, particularly preferably 20 to 80 wt. %, and/or   the proportion of the total quantity of compounds of the formula (Y) and salts of compounds of the formula (Y) in the mixture, based on the total weight of the mixture, is 1 to 99 wt. %, preferably 10 to 99 wt. %, particularly preferably 20 to 80 wt. %,
 
wherein preferably the proportion of the total quantity of compounds of the formula (X), compounds of the formula (Y), salts of compounds of the formula (X) and salts of compounds of the formula (Y) in the mixture, based on the total weight of the mixture, is 0.0001 to 100 wt. %, preferably 0.001 to 100 wt. %, particularly preferably 0.1 to 90 wt. %, more preferably 1 to 90 wt. %. According to an especially preferred embodiment, the proportion is 10 to 90 wt. %, in particular 25 to 90 wt. % (preferably up to 100 wt. %), more preferably 45 to 90 wt. % (preferably up to 100 wt. %).
       

     Surprisingly, in our own studies it was found that certain extracts prepared from Herba Santa foliage or fractions therefrom are particularly suitable for treating inflammatory processes, for example with inflammation in the gastrointestinal tract or gingivitis, and/or preventing these. Hence, according to a further aspect of the present invention, a mixture is stated for the use described according to the invention, wherein the mixture comprises a plant extract or consists thereof, preferably an extract from  Eriodictyon  ssp., particularly preferably an extract from  Eriodictyon californicum  and/or  Eriodictyon angustifolium , wherein the proportion of the total quantity of compounds of the formula (X) and salts of compounds of the formula (X) in the mixture, based on the total weight of the mixture, is preferably 0.1 to 100 wt. %, more preferably 1 to 100 wt. %, particularly preferably 10 to 100 wt. %, and more preferably from 10 to 90 wt. %. 
     Particularly preferably, the ratio of the total quantity of compounds of the formula (X) and salts of compounds of the formula (X) to the total quantity of compounds of the formula (Y) and salts of compounds of the formula (Y) in a mixture described herein usable according to the invention lies in the range from 0.00001:1 to 1:0.00001, in particular in the range from 0.0001:1 to 1:0.0001, preferably in the range from 0.001:1 to 1:0.001, preferably in the range from 0.01:1 to 1:0.01, particularly preferably in the range from 0.1:1 to 1:0.1, and more preferably in the range from 0.5:1 to 1:0.5, each based on the weight. 
     According to a preferable embodiment of the present invention, a mixture described herein comprises as compounds of the formula (Y) homoeriodictyol and sterubin or salt(s) thereof. Here, as regards preferable quantity data and ratios, the aforesaid respectively applies. 
     In a preferable embodiment of such a mixture, the mixture contains a total quantity of homoeriodictyol and sterubin (and/or salts thereof) which is greater than the total quantity of compounds of the formula (X) (and optionally salts thereof). 
     Preparations 
     The present invention also relates to preparations, in particular preparations used for food or enjoyment, pharmaceutical preparations, cosmetic preparations or dermatological preparations for use in a method for the prophylaxis and/or treatment of inflammation, comprising a compound, a salt or a mixture as defined above, for use in a method for the prophylaxis and/or treatment of inflammation. 
     Preferably these are preparations for the prophylaxis and/or treatment of inflammation of the skin (as described above), in particular in a method
         for reducing the release of TNF-alpha, and/or   for reducing the release of an interleukin, preferably of IL-1, IL-6 and/or IL-8, and/or   for reducing the release of a prostaglandin, preferably of PGE2, and/or   for reducing the release of interferon-gamma and/or NF-κB,
 
particularly preferably in a method
   for reducing the release of TNF-alpha, and/or   for reducing the release of an interleukin, preferably of IL-1, IL-6 and/or IL-8, and/or   for reducing the release of a prostaglandin, preferably of PGE2.       

     Preferably here this is also
     (a) a method for the prophylaxis and/or treatment of chronic inflammatory diseases, in particular intestinal diseases, and/or   (b) a method for strengthening damaged or undamaged skin, in particular mucosa, and/or   (c) a method for reducing tissue damage, in particular tissue damage in the intestine, and/or   (d) a method for recreating a normal cellular composition in the intestine, and/or   (e) a method for recreating or stabilizing the function of skin, in particular of mucosa.   

     Moreover, the aforesaid also respectively applies, in particular as regards the contained compounds of the formula (X) or salts thereof and the optionally contained compounds of the formula (Y) or salts thereof. 
     Preferably a preparation described above contains a mixture preferred according to the invention (as described above). 
     Preparation of the Mixtures 
     A mixture according to the invention or a mixture usable according to the invention, preferably a mixture described above as preferable, is preferably producible by a method with the following steps:
     (a) Extraction of plant material from  Eriodictyon  ssp., preferably from  Eriodictyon californicum  and/or  Eriodictyon angustifolium , so that a mixture is formed which contains compounds of the formula (X), optionally compounds of the formula (Y) and other extracted compounds, and   (b) Concentration of extracted compounds of the formula (X) and/or salts of the extracted compounds of the formula (X) and optionally compounds of the formula (Y) and/or salts of the extracted compounds of the formula (Y) in the mixture by partial or complete removal of other extracted compounds and optionally removal of extractants and/or solvents,
 
preferably so that the proportion of the total quantity of compounds of the formula (X) and salts of compounds of the formula (X) in the mixture based on the total weight of the mixture is 0.1 to 100 wt. %, more preferably 1 to 100 wt. %, particularly preferably 10 to 100 wt. %, more preferably from 10 to 90 wt. %.
   

     Preferably the plant material here is selected from the group consisting of:
           Eriodictyon altissimum  P. V. Wells—Indian Knob mountain balm     Eriodictyon angustifolium  Nutt.—Narrow-leaved Yerba Santa     Eriodictyon californicum  (Hook. &amp; Arm.) Torr.—California Yerba Santa     Eriodictyon capitatum  Eastw.—Lompoc Yerba Santa     Eriodictyon crassifolium  Benth.—Thick-Leaved Yerba Santa     Eriodictyon tomentosum  Benth     Eriodictyon traskiae  and     Eriodictyon trichocalyx  (Syn.:  Eriodictyon lanatum  (Brand) Abrams)—Hairy Yerba Santa       

     According to a preferable aspect of the present invention, a mixture described herein or a preparation described herein comprises or consists of an appropriately concentrated extract from Herba santa, preferably from plant material as described above. 
     In the context of the present invention, an extract from fresh or dried Herba Santa plants or plant parts is preferable, particularly preferably from plants or plant parts with a solids content of 90 wt. % or more. Particularly preferably, the extract is from above-ground plant parts, in particular from leaves, buds, stems, bark, flowers and/or fruit of  E. angustifolium  or  E. californicum.    
     Extracts from Herba Santa foliage (as described above) can be obtained by extraction methods known per se from the fresh or dried foliage of the plants. These for example include maceration or percolation. As the extraction medium, for example water and ethanol or mixtures thereof can be used. Instead of ethanol, methanol and other water-soluble solvents can also be used. Likewise, ethyl acetate can be used as a solvent. Selection of the temperature and mechanical disintegration of the fruit can promote the extraction. According to the state of the art, the mechanical disintegration of the dried foliage e.g. with stirrers, homogenizers or ultrasound is also advisable. Further, other extraction-promoting substances, such as acids, bases and enzymes, can be used. 
     In the context of the present text, the term “Herba Santa foliage” in particular comprises leaves, buds, bark, flowers, fruit and stems of  Eriodictyon angustifolium, E. californicum, E. trichocalyx, E. traskiae , and  E. crassifolium.    
     The identification and quantification of flavones and bisprenylated benzoic acid derivatives in different  Eriodictyon  sp. can be effected by means of RP-HPLC-UV/Vis and RP-HPLC-MS/MS after the methanolic extraction, as performed in the context of our own studies. The flavonoid contents, or contents of bisprenylated benzoic acid derivatives can be determined by means of external calibration with use of standard substances. The appended  FIGS. 1   a  and  1   b  respectively show by way of example the flavonoid or erionic/eriolic acid profile of extracts studied ( FIG. 1   a : LC-MS chromatogram of the flavonoid fraction from  Eriodictyon angustifolium  extract;  FIG. 1   b : LC-MS chromatogram of the erionic acid fraction from  Eriodictyon angustifolium  extract; each after fractionation over Sephadex LH-20). 
     In the light of the above explanations, a preparation according to the invention or a mixture according to the invention (as respectively described above) preferably comprises or consists of (i) Herba Santa foliage, (ii) an optionally concentrated extract prepared therefrom or (iii) a fraction thereof. 
     Additives for the Mixtures 
     In the mixtures or preparations according to the invention, as well as the components described above, one or more further substances can be contained. Preferably one or more (further) substances which are suitable for influencing inflammatory states of the skin, in particular for prophylactic and/or therapeutic uses as described above, are contained. Furthermore, one or more substances for the treatment of a deficiency phenomenon arising during inflammation of the skin (in particular a deficiency of potassium, sodium, iron, calcium, vitamin D and/or folic acid) can be contained. 
     In the mixtures or preparations according to the invention, one or more further components selected from the following group are preferably (also) contained: probiotic bacteria (e.g. lactobacilli, bifidobacteria and enterococci), prebiotics (e.g. inulin and fructooligosaccharides), synbiotics (pro- and prebiotics), ballast substances (e.g. cellulose, starch, resistant starch and fibres, such as for example apple fibres), whey proteins, soya proteins, minerals (in particular Ca, Mg, with a combination of Ca, Mg and inulin being particularly preferable), tocopherols (e.g. vitamin E, vitamin E acetate), vanilla, vanilla extracts, omega-3 fatty acids (preferably fish oil), citrus, apple, grape seed, green tea, rosemary, tarragon, thyme, horseradish and mace extracts, tannins, tomato, melon and rose hip extracts (in particular lycopene-containing extracts), betacarotene; aubergines, rhubarb, red onions, red cabbage, black carrot, superfruits, in particular agai, noni, goji, pomegranate, mangosteen, currrants, strawberries, aronia, blueberries and/or elderberries, preferably in the form of dried fruit, extracts or fruit preparations; soya isoflavones, nonsteroidal antiinflammatory drugs, antibiotics, budesonide, systemically active steroids, sulfasalazine, azathioprine/6-mercaptopurine, methotrexate, anti-TNF-alpha antibodies, bisabolol, sodium laurylsulphate, chlorhexidine, metal fluorides (e.g. aluminium and tin fluoride), organic and inorganic fluorides, flavourings, essential oils, cooling active substances, in particular menthol, extracts or pure substances from eucalyptus, thyme, wintergreen, spearmint and peppermint. 
     Final Preparations for Customers 
     Preparations according to the invention (in particular the preparations designated above as preferable) are preferably selected from the group consisting of:
         Fruit juice-containing drinks; vegetable juice-containing drinks; bakery products; confectionery; snacks; instant products; soups; sauces; spice mixtures; ice cream; fruit preparations; desserts; dairy products; soya products; cereals; food supplements, medicinal products and pharmaceutical products.   Fruit juice-containing drinks here are in particular fruit juices and smoothies (whole fruit drinks). Vegetable juice-containing drinks are in particular juices of red beet and black carrot.   Bakery products are in particular cakes, waffles and biscuits.   Confectionery is in particular lozenges and chewing gums, fruit gums, chewing sweets, (breath freshening) sweets, boiled sweets, hard caramels, chocolate creams, sweets and chocolate.   Instant products are in particular instant meals and other instant products, e.g. drink powders and granules.   Fruit preparations are in particular jams, preserves and fruit sauces.   Desserts are in particular puddings and jellies.   Dairy products comprise in particular quark, yoghurt, milk drinks and whey preparations.   Cereals are in particular cornflakes, muesli and muesli bars.   Further preferable preparations, in particular food supplements, medicinal products and pharmaceutical products, are   Solid galenical forms (such as for example tablets (with and without coating, with and without modified release), sugar-coated tablets (with and without coating, with and without modified release), capsules (soft or hard gelatine capsules with and without modified release) granules (with and without modified release), powders (with and without modified release), suppositories (with and without coating, with and without modified release), lozenges and chewing gums),   Liquid forms (such as for example solutions, suspensions, emulsions, syrups (colloquially cough syrup), mouthwashes, gargle solutions, throat sprays or nasal sprays, nasal drops, nasal rinse solutions, nasal powders, nasal ointments or ear drops, ear sprays, ear rinse solutions, ear powders and aural tampons),   Semisolid forms (such as for example hydrophobic ointments including for example: hydrocarbon gels, lipogels, silicone gels, oleogels and water-absorbing ointments including for example absorption bases, hydrophilic ointments, hydrophilic gels (hydrogels) or pastes,   Inhalants (such as for example compressed gas dispenser inhalers, powder inhalers, inhalers with atomisers, and inhalation concentrates for inhalation),   Active substance-containing plasters or other therapeutic systems and   Cosmetic and/or dermatological preparations, which (except for the substances to be used according to the invention) are constituted as usual and are used for cosmetic, in particular dermatological sun protection, for the treatment, care and cleansing of the skin and/or the hair or as a make-up product in decorative cosmetics. Accordingly, such preparations can be present as for example cleaning agents such as for example soap, syndet, liquid wash, shower and bath preparation, skin care agents such as for example emulsion (as solution, dispersion, suspension; cream, lotion or milk depending on production method and ingredients of the type W/O, O/W or multiple emulsion, PIT emulsion, emulsion foam, micro- or nanoemulsion, Pickering emulsion), ointment, paste, gel (including hydro-, hydrodispersion- and oleogel), alcoholic or aqueous/alcoholic solution, oil, toner, balsam, serum, powder, wipe, Eau de Toilette, Eau de Cologne, perfume, wax, including the presentation as stick, roll-on, (pump-)spray, aerosol (foaming, non-foaming or after-foaming), skin care products (as described above), as foot care products (including keratolytic agents and deodorants), as insect repellents, as sunscreen agents, as self-tanning agents and/or aftersun preparations, skin care products as shaving products or after-shave, as depilatory agents, as hair care products such as for example shampoo (including shampoo for normal hair, for greasy hair, for dry, stressed (damaged) hair, 2-in-1 shampoo, antidandruff shampoo, baby shampoo, shampoo for dry scalp, shampoo concentrate), conditioner, hair mask, hair lotion, hair conditioner, hair cream, pomade, permanent wave and fixing agents, hair straighteners (straighteners, relaxers), hair setting lotions, styling aids (e.g. gel or wax); bleaching agents, hair dyes such as for example temporary, direct and semipermanent hair dyes, permanent hair dyes), skin care products as decorative toiletry products, such as for example nail care products (nail varnish and nail varnish remover), decorative cosmetics (e.g. powder, eyeshadow, eye pencil, lipstick), skin care products as deodorant and/or antiperspirant; mouthwash and oral waterjet, and   Oral care products (e.g. toothpaste, tooth cream, tooth gel, tooth powder, tooth cleaning fluid or foam, mouthwash, tooth cream and mouthwash as 2-in-1 product, mouth spray, dental floss or dental care chewing gum). Such oral or dental care products as a rule contain abrasive systems (abrasive or polishing ingredients), such as silicates, calcium carbonate, calcium phosphate, aluminium oxide and/or hydroxyapatite, surfactant substances, e.g. sodium laurylsulphate, sodium laurylsarcosinate and/or cocamidopropyl betaine, humectants such as glycerol and/or sorbitol, thickeners, e.g. carboxymethylcelluloses, polyethylene glycols, carrageenan and/or Laponite®, sweeteners such as saccharin, flavour/taste correctants for unpleasant taste sensations, taste-modulating substances (e.g. inositol phosphate, nucleotides, e.g. guanosine monophosphate, adenosine monophosphate or other substances, e.g. sodium glutamate or 2-phenoxypropionic acid), cooling active substances, e.g. menthol derivatives (e.g. L-menthyl lactate, L-menthyl alkyl carbonates, menthone ketals), icilin and icilin derivatives, stabilizers and active substances, e.g. sodium fluoride, sodium monofluorophosphate, tin difluoride, quaternary ammonium fluorides, zinc citrate, zinc sulphate, tin pyrophosphate, tin dichloride, mixtures of various pyrophosphates, triclosan, cetylpyridinium chloride, aluminium lactate, potassium citrate, potassium nitrate, potassium chloride, strontium chloride, hydrogen peroxide, flavourings, sodium bicarbonate and/or odour correctants, and   Chewing gums or dental care gums consisting of a chewing gum base containing elastomers, e.g. polyvinyl acetates (PVA), polyethylenes, (low or medium molecular weight) polyisobutenes (PIB), polybutadienes, isobutene-isoprene copolymers, polyvinyl ethyl ethers (PVE), polyvinyl butyl ethers, copolymers of vinyl esters and vinyl ethers, styrene/butadiene copolymers (SBR) or vinyl elastomers, e.g. based on vinyl acetate/vinyl laurate, vinyl acetate/vinyl stearate or ethylene/vinyl acetate, and mixtures of the said elastomers such as for example described in EP 0 242 325, U.S. Pat. No. 4,518,615, U.S. Pat. No. 5,093,136, U.S. Pat. No. 5,266,336 U.S. Pat. No. 5,601,858 or U.S. Pat. No. 6,986,709. In addition, chewing gum bases contain further ingredients, e.g. (mineral) fillers (e.g. calcium carbonate, titanium dioxide, silicon dioxide, talc, aluminium oxide, dicalcium phosphate, tricalcium phosphate, magnesium hydroxide and mixtures thereof, plasticizers (e.g. lanolin, stearic acid, sodium stearate, ethyl acetate, diacetin (glycerol diacetate), triacetin (glycerol triacetate) and triethyl citrate), emulsifiers (e.g. phosphatides, such as lecithin and mono and diglycerides of fatty acids, e.g. glycerol monostearate), antioxidants, waxes (e.g. paraffin waxes, candelilla waxes, carnauba wax, microcrystalline waxes and polyethylene waxes), fats or fatty oils (e.g. hardened (hydrogenated) plant or animal fats) and mono, di- or triglycerides.       

     Preferable preparations according to the invention used for food or enjoyment are: 
     Confectionery such as for example lozenges and chewing gums, fruit gums, chewing sweets, (breath freshening) sweets, boiled sweets, hard caramels, chocolate creams, sweets and chocolate, bakery products such as cakes, waffles and biscuits, snacks, instant meals and other instant products (drink powders and granules), ice cream, fruit preparations (jams, preserves and fruit sauces), desserts (puddings, jellies), dairy products (quark, yoghurts, probiotic yoghurts, milk drinks, whey preparations) and cereals (cornflakes, muesli and muesli bars). 
     Especially preferred preparations according to the invention used for food or enjoyment are fruit gums, fruit preparations (jams, preserves and fruit sauces), dairy products (quark, yoghurts, probiotic yoghurts, milk drinks, whey preparations) and cereals (cornflakes, muesli and muesli bars), wherein in turn the dairy products yoghurts, probiotic yoghurts and milk drinks are most preferred. 
     Additives for the Preparations 
     As further components for preparations according to the invention used in particular for food or enjoyment, normal primary, auxiliary and additive substances for food or luxury consumables can be used, e.g. water, mixtures of fresh or processed, plant or animal primary or raw substances (e.g. raw, roast, dried, fermented, smoked and/or boiled meat, bones, cartilage, fish, vegetables, fruit, spices, nuts, vegetable or fruit juices or pastes or mixtures thereof), digestible or non-digestible carbohydrates (e.g. amylose, amylopectin, inulin, xylans, cellulose), natural or hardened fats (e.g. tallow, lard, palm fat, coconut fat, hardened plant fat), oils (e.g. sunflower oil, peanut oil, maize oil, olive oil, fish oil, soya oil, sesame oil), fatty acids or salts thereof (e.g. potassium stearate), proteinogenic or non-proteinogenic amino acids and related compounds (e.g. γ-amino-butyric acid, taurine), peptides (e.g. glutathione), native or processed proteins (e.g. gelatine), enzymes (e.g. peptidases), nucleic acids, nucleotides, taste correctants for unpleasant taste sensations, further taste modulators for further, as a rule not unpleasant taste sensations, other taste-modulating substances (e.g. inositol phosphate, nucleotides such as guanosine monophosphate, adenosine monophosphate or other substances such as sodium glutamate or 2-phenoxypropionic acid), emulsifiers (e.g. lecithins, diacylglycerols, gum Arabic), stabilizers (e.g. carrageenan, alginate), preservatives (e.g. benzoic acid, sorbic acid), antioxidants (e.g. tocopherol, ascorbic acid), chelators (e.g. citric acid), organic or inorganic acidulants (e.g. malic acid, acetic acid, citric acid, tartaric acid, phosphoric acid), bitter substances (e.g. quinine, caffeine, limonin, amarogentin, humolone, lupolone, catechins, tannins), mineral salts (e.g. sodium chloride, potassium chloride, magnesium chloride, sodium phosphate), substances preventing enzymatic browning (e.g. sulphite, ascorbic acid), essential oils, plant extracts, natural or synthetic dyes or pigments (e.g. carotenoids, flavonoids, anthocyans, chlorophyll and derivatives thereof), spices, trigeminally active substances or plant extracts, containing such trigeminally active substances, cooling active substances such as for example menthol, menthol derivatives (e.g. L-menthol, L-menthyl lactate, L-menthyl glutarate, L-menthyl succinate) or cubebol, synthetic, natural or nature-identical flavourings or aromatic substances and odour correcta nts. 
     Preparations according to the invention, used in particular for food or enjoyment can additionally contain one or more taste correctants, preferably selected from the following list: nucleotides (e.g. adenosine 5′-monophosphate, cytidine 5′-monophosphate) or pharmaceutically acceptable salts thereof, lactisols, sodium salts (e.g. sodium chloride, sodium lactate, sodium citrate, sodium acetate, sodium gluconate), further hydroxy-flavanones (e.g. eriodictyol, homoeriodictyol or sodium salts thereof), in particular according to US 2002/0188019, hydroxybenzamides as per DE 10 2004 041 496 (e.g. 2,4-dihydroxybenzoic acid vanillylamide, 2,4-dihydroxybenzoic acid N-(4-hydroxy-3-methoxybenzyl)amide, 2,4,6-trihydroxybenzoic acid N-(4-hydroxy-3-methoxybenzyl)-amide, 2-hydroxybenzoic acid N-4-(hydroxy-3-methoxybenzyl)amide, 4-hydroxybenzoic acid N-(4-hydroxy-3-methoxybenzyl)amide, 2,4-dihydroxybenzoic acid N-(4-hydroxy-3-methoxybenzyl)amide monosodium salt, 2,4-dihydroxybenzoic acid N-2-(4-hydroxy-3-methoxyphenyl)ethylamide, 2,4-dihydroxybenzoic acid N-(4-hydroxy-3-ethoxybenzyl)-amide, 2,4-dihydroxybenzoic acid N-(3,4-dihydroxybenzyl)amide and 2-hydroxy-5-methoxy-N-[2-(4-hydroxy-3-methoxyphenyl)ethyl]amide (aduncamide), 4-hydroxybenzoic acid vanillylamide), bitter-masking hydroxydeoxybenzoins according to WO 2006/106023 and the documents based thereon (Symrise) (e.g. 2-(4-hydroxy-3-methoxyphenyl)-1-(2,4,6-trihydroxyphenyl)ethanone, 1-(2,4-dihydroxyphenyl)-2-(4-hydroxy-3-methoxy-phenyl)ethanone, 1-(2-hydroxy-4-methoxyphe-nyl)-2-(4-hydroxy-3-methoxyphenyl)ethanone), amino acids (e.g. gamma-aminobutyric acid as per WO 2005/096841 for reduction or masking of an unpleasant taste sensation such as bitterness), malic acid glycosides as per WO 2006/003107, salty-tasting mixtures as per WO 2007/045566, diacetyl trimers as per WO 2006/058893, divanillin, mixtures of whey proteins with lecithins and/or bitter-masking substances such as gingerdiones according to WO 2007/003527. 
     Preparations according to the invention used in particular for food or enjoyment can additionally contain one or more alkamides, preferably selected from the group consisting of: 2E,4E-decadienoic acid N-isobutylamide (pellitorin), 2E,4Z-decadienoic acid N-isobutylamide (cispellitorin), 2Z,4Z-decadienoic acid N-isobutylamide, 2Z,4E-decadienoic acid N-isobutylamide, 2E,4E-decadienoic acid N-([2S]-2-methylbutyl)amide, 2E,4E-decadienoic acid N-([2S]-2-methylbutylamide, 2E,4E-decadienoic acid N-([2R]-2-methylbutylamide), 2E,4Z-decadienoic acid N-(2-methylbutyl)amide, 2E,4E-decadienoic acid N-piperide (achilleamide), 2E,4E-decadienoic acid N-piperide (sarmentin), 2E-decenoic acid N-isobutylamide, 3E-decenoic acid N-isobutylamide, 3E-nonenoic acid N-isobutylamide, 2E,6Z,8E-decatrienoic acid N-isobutylamide (spilanthol), 2E,6Z,8E-decatrienoic acid N-([2S]-2-methylbutyl)amide (homospilanthol), 2E,6Z,8E-decatrienoic acid N-([2R]-2-methylbutyl)amide, 2E-decen-4-ynic acid N-isobutylamide, 2Z-decen-4-ynic acid N-isobutylamide, sanshoole. 
     Preparations according to the invention, used in particular for prophylaxis and supplementation of food and for the therapy of disease states and for toiletries can preferably contain substances or combinations of substances from the following groups. 
     Fillers (e.g. cellulose, calcium carbonate), free-flow and anticaking agents (e.g. talc, magnesium stearate), coatings (e.g. polyvinyl acetate phthalate, hydroxypropyl-methylcellulose phthalate), disintegrants (e.g. starch, crosslinked polyvinylpyrrolidone), plasticizers (e.g. triethyl citrate, dibutyl phthalate) substances for granulation (lactose, gelatine), retardation (e.g. poly(meth)acrylic acid methyl/ethyl/2-trimethylaminoethyl ester copolymers in dispersion, vinyl acetate/crotonic acid copolymers) and compacting (e.g. microcrystalline cellulose, lactose), solvent, suspension or dispersion agents (e.g. water, ethanol), emulsifiers (e.g. cetyl alcohol, lecithin), substances for modification of the rheological properties (silicon dioxide, sodium alginate), substances for microbial stabilization (e.g. benzalkonium chloride, potassium sorbate), preservatives and antioxidants (e.g. DL-alpha-tocopherol, ascorbic acid), substances for modification of the pH (lactic acid, citric acid), propellant or inert gases (e.g. fluorinated chlorohydrocarbons, carbon dioxide), colorants (iron oxides, titanium dioxide), ointment bases (e.g. paraffins, beeswax), inter alia as described in the technical literature (e.g. Schmidt, Christin. Active and Auxiliary Substances for Individual and Bulk Formulation, and Large-scale Manufacture. 1999; Wissenschaftliche Verlagsgesellschaft mbH Stuttgart or Bauer, Frömming Fuhrer. Textbook of Pharmaceutical Technology. 8 th  Edition, 2006. Wissenschaftliche Verlagsgesellschaft mbH Stuttgart). 
     Depending on the embodiment according to the invention and desired purpose, mixtures according to the invention (as described above) can also contain one or more of the components mentioned above in connection with preparations according to the invention. 
     INDUSTRIAL APPLICATION 
     A further aspect of the present invention relates to a compound, a salt, a mixture or a preparation, as respectively described or defined above, for use in a method for the treatment of animal or human skin which requires treatment with anti-inflammatory active substances. Regarding the selection of the compounds or the salts and the preferable composition of the mixtures and preparations, the aforesaid respectively applies. 
     The compounds (1) to (16) described herein advantageously possess a particularly strong anti-inflammatory action. The compounds (1) to (16) are advantageously suitable for supporting the natural defence mechanisms against inflammatory processes in physiological systems (of people and animals). Further, these compounds advantageously occur in plants with a long edible consumption history (e.g. Herba Santa) owing to which they are particularly suitable for use in foods. 
     Particularly advantageous according to the invention therefore is a mixture or a preparation as described above, where this comprises one, two, three, four, five, six, seven, eight, nine or all compounds (1) to (10) and also one, two, three, four, five or all compounds (11) to (16) or consists thereof. Particularly preferable here is a mixture or a preparation, which comprises all of the compound (1) to (16) or consists thereof. 
     Such a mixture or preparation wherein one, several or all compounds of the group of the compounds (1) to (16) are components of a plant extract, preferably an extract from eriodictyon ssp., particularly preferably an extract from  eriodictyon californicum  and/or  eriodictyon angustifolium , is particularly preferable. 
     It was particularly surprising that the compounds of the formula (X) to be used according to the invention or salts thereof can mediate or possess strong anti-inflammatory effects. Compounds, salts, mixtures and preparations according to the invention (as respectively described above) are advantageously capable of positively influencing inflammatory parameters in monocytes. In cell models wherein irritated and inflammatory phenomena of the mucous membranes, especially of gingiva and the gastrointestinal tract, are simulated, these exhibit an anti-inflammatory action. In particular, the following inflammatory parameters are positively influenced according to the invention: PGE2, IL-1, TNF, IL-6 and IL 8, in particular PGE2. Appropriate experiments on this were performed as described in TS1 (see below, “Example TS: Test study”). Thus for example from a concentration of 1 μg/ml, eriol-/erion-containing fractions already exhibit a highly significant action on some of the abovementioned parameters. Concentrations of 10 μg/ml and more are particularly suitable. A total extract from Herba Santa foliage which contains compounds usable according to the invention or individual extracts therefrom for example exhibits significant effects on individual parameters from a concentration of 1 μg/ml and highly significant effects up to 250 μg/ml. 
     For salts of compounds of the formula (X) usable according to the invention, that stated further above respectively applies as regards the preferable meanings of the residues. The carboxylic acid group which is bound to the carbon atom in position 1 (according to the numbering shown in formula (X)) is then present deprotonated. In addition, one or more hydroxy groups (if present) are optionally also present deprotonated. Here, as well as the deprotonated compound(s) of the formula (X), a corresponding quantity of counter-cations are present, where these are preferably selected from the group consisting of: singly positively charged cations of the first main and transition group, ammonium ions, trialkylammonium ions, doubly positively charged cations of the second main and transition group and triply positively charged cations of the third main and transition group, and mixtures thereof. The maximum degree of deprotonation of a compound of the formula (X) on which such as salt is based is found from the carboxyl group and the hydroxy groups of this compound lying adjacent thereto. In turn, from the number of deprotonated groups, the corresponding number of counter-cations is obtained (depending on their charge). Thus for example for a compound of the formula (X) with one carboxyl and one hydroxy group on which such as salt is based, it is found that with complete deprotonation of the groups a doubly negatively charged anion is present, from which in turn the number of positive charges is found (here: two), which must be provided by the countercation(s). Particularly preferably, these counter-cations are cations selected from the group consisting of Na + , K + , NH 4   + , Ca 2+ , Mg 2+ , Al 3+  and Zn 2+ . 
     Particularly preferable therefore is a salt of a compound of the formula (X) or a mixture (as respectively described above) containing or consisting of
         one, two or more different salts of compounds of the formula (X), preferably of compounds of the formula (X) previously designated as preferable, and optionally   one, two or more different salts of compounds of the formula (Y), preferably of compounds of the formula (Y) previously designated as preferable, or   one or more different compounds of the formula (X) and/or one or more different salts of compounds of the formula (X), and optionally   one or more different compounds of the formula (Y) and/or one or more different salts of compounds of the formula (Y),
 
wherein the counter-cation(s) of one, several or all of the salts of compounds of the formula (X) and/or compounds of the formula (Y) is or are selected from the group consisting of Na + , K + , NH 4   + , Ca 2+ , Mg 2+ , Al 3+  and Zn 2+ .
       

     As aforesaid, one, several or all of the compounds of the formula (X) or salts of compounds of the formula (X) to be used according to the invention, and optionally one, several or all of the compounds of the formula (Y) or salts of compounds of the formula (Y) can also be used in the form of plant extracts, in particular in the form of extracts from  Eriodictyon  ssp., in particular from  Eriodictyon californicum  and/or  Eriodictyon angustifolium , optionally after treatment with a base for conversion of the compound(s) of the formula (X) or (Y) into a salt. 
     Preferably the dried plant parts (see above) used in the context of the present invention e.g. fresh or dried roots, root bark, tubers, onions, other under- or aboveground storage organs, accessory fruit, fruit, seeds, bark, wood, pulp, bast, stems, stalks, leaves or flower [parts], preferably the stems, stalks, leaves and flower [parts], preferably in comminuted form, are extracted with a solvent suitable for food and luxury consumables at temperatures in the range between the freezing point and the boiling point of the particular solvent or solvent mixture, then filtered and the filtrate wholly or partially concentrated, preferably by distillation, or freeze- or spray-drying. The crude product thus obtained can then be still further worked up, for example back-extracted, purified via distribution, absorption, exclusion, affinity or ion chromatography, distilled, sublimed, purified with adsorbents such as activated charcoal, bentonite, diatomaceous earth, etc., treated enzymatically (e.g. with glycosidases to increase yield of non-sugar-containing molecules), with acid (e.g. under pressure), with suitable basic solutions e.g. of hydroxides, carbonates or hydrogen carbonates of sodium, potassium, calcium, magnesium and zinc, with acidic ion exchangers or with steam, as a rule at pressures from 0.01 mbar to 100 bar, preferably at 1 mbar to 20 bar, treated with an auxiliary and carrier substance and optionally dried (e.g. spray dried) and/or taken up in a solvent suitable for food and luxury consumables and/or for cosmetic and dermatological uses. 
     Suitable solvents for the extraction are in particular water, ethanol, methanol, propylene glycol, glycerine, acetone, dichloromethane, ethyl acetate, diethyl ether, hexane, heptane, triacetin, plant oils or fats, supercritical carbon dioxide and mixtures thereof. 
     Preferable auxiliary or carrier substances are maltodextrin, starch, natural or synthetic polysaccharides and/or plant gums such as modified starches or gum Arabic, colouring agents, e.g. permitted food dyes, colouring plant extracts, stabilizers, preservatives, antioxidants and viscosity-modifying substances. 
     Particularly preferable is a mixture according to the invention (as described above), wherein the mixture comprises a plant extract or consists thereof, preferably an extract from  Eriodictyon  ssp., particularly preferably an extract from  Eriodictyon californicum  and/or  Eriodictyon angustifolium . A mixture preferred according to the invention or a mixture preferably to be used according to the invention (as described above) according to one embodiment of the present invention particularly preferably comprises or consists of (1.) an extract from  Eriodictyon californicum , (2.) an extract from  Eriodictyon angustifolium  or (3.) an extract from  Eriodictyon californicum  and  Eriodictyon angustifolium , i.e. an extract from plants or plant parts from both  Eriodictyon californicum  and also  Eriodictyon angustifolium , or (4.) a mixture of an extract from  Eriodictyon californicum  and an extract from  Eriodictyon angustifolium.    
     Particularly preferably, a mixture according to the invention or a mixture preferably to be used according to the invention (as respectively described above) consists of an extract from  Eriodictyon  ssp., particularly preferably of an extract from  Eriodictyon californicum  and/or  Eriodictyon angustifolium . The production of a plant extract from  Eriodictyon californicum  and/or  Eriodictyon angustifolium  is described later herein. 
     As described above, one aspect of the present invention relates in particular to a preparation used for food or enjoyment, in particular a food, luxury consumable or drink, or a cosmetic or dermatological preparation, in particular a preparation suitable for the treatment, protection and/or care of the skin, nails and/or hair and of the oral cavity (in particular of the gingiva and the teeth), or a pharmaceutical preparation, for the treatment of inflammatory states of the body of warm-blooded animals. As regards the composition of such a preparation, reference is essentially made to the above explanations. 
     According to a preferable embodiment of the present invention, the proportion of the total quantity of compounds of the formula (X) and (optionally) compounds of the formula (Y) and salts thereof in the preparation lies in the range from 0.0001 to 30 wt. %, preferably in the range from 0.001 to 20 wt. %, particularly preferably in the range from 0.001 to 5 wt. %, based on the total weight of the preparation. 
     Preparations according to the invention, in particular preparations according to the invention used for food or enjoyment, in the context of the present invention can in particular be embodied as compositions suitable for consumption (as described below). The preparations used for food or enjoyment in the sense of the present invention can also be used as semifinished goods for the production of further preparations used for food or enjoyment. 
     The preparations according to the invention used for food or enjoyment and corresponding semifinished goods and preparations or compositions suitable for consumption are as a rule products which are intended to be introduced into the human oral cavity, to remain there for a certain time and then either be consumed (e.g. ready-to-eat foods, see below) or removed again from the oral cavity (e.g. chewing gums). Thus these products include all articles or substances which are intended to be ingested by people, in the processed, partially processed or unprocessed state. In particular, compositions suitable for consumption are articles which products which are added to foods during the production, processing or modification thereof and are intended to be introduced into the human oral cavity, in particular with the said food. Accordingly, such compositions can in turn be contained in (further) ready-to-use or ready-to-eat preparations used for food or enjoyment (in the context of the present text, ready-to-use or ready-to-eat preparations used for food or enjoyment are in particular foods, especially ready-to-eat foods (see below)). In addition, such compositions can be a component of a semifinished product which optionally can in turn be used for the production of ready-to-use or ready-to-eat preparations used for food or enjoyment. 
     Preparations used for food or enjoyment in the sense of the present invention are in particular ready-to-use or ready-to-eat preparations, in particular foods, especially ready-to-eat foods, e.g. bakery products (e.g. bread, dry biscuits, cakes, other pastries), confectionery (e.g. chocolates, chocolate bar products, other products in bars, fruit gum, hard and soft caramels, chewing gum), alcoholic or non-alcoholic drinks (e.g. coffee, tea, wine, wine-containing drinks, beer, beer-containing drinks, liqueurs, spirits, brandies, fruit-containing soft drinks, isotonic drinks, refreshment drinks, nectars, fruit and vegetable juices, fruit or vegetable juice preparations), instant drinks (e.g. instant cocoa drinks, instant tea drinks, instant coffee drinks), meat products (e.g. ham, fresh sausage or raw sausage preparations, spiced or marinated fresh or pickled meat products), eggs or egg products (dried egg, egg white, egg yolk), cereal products (e.g. breakfast cereals, muesli bars, prefermented prepared rice products), dairy products (e.g. milk drinks, milk-based ice cream, yoghurt, kefir, cream cheese, soft cheese, hard cheese, dried milk powder, whey, butter, buttermilk, partially or fully hydrolyzed milk protein-containing products), products from soya protein or other soya bean fractions (e.g. soya milk and products prepared therefrom, soya lecithin-containing preparations, fermented products such as tofu or tempe or products prepared therefrom, soya sauces), fruit preparations (e.g. preserves, fruitflavoured ice cream, fruit sauces, fruit fillings), vegetable preparations (e.g. ketchup, sauces, dried vegetables, deep-frozen vegetables, prefermented vegetables, vegetables marinated in vinegar, preserved vegetables), nibbles (e.g. baked or fried potato crisps or potato dough products, bread dough products, maize- or peanut-based extruded products), fat and oil-based products or emulsions thereof (e.g. mayonnaise, remoulade, dressings, spice preparations), other ready-to-serve meals and soups (e.g. dried soups, instant soups, prefermented soups), spices, spice mixtures and in particular seasonings), which are for example used in the snacks field. 
     Preferable carrier substances contained in such (preferably spray dried) compositions according to the invention are silicon dioxide (silicic acid, silica gel), carbohydrates and/or carbohydrate polymers (polysaccharides), cyclodextrins, starches, degraded starches (starch hydrolyzates), chemically or physically modified starches, modified celluloses, gum Arabic, ghatti gum, tragacanth, karaya, carrageenan, guar gum, carob flour, alginates, pectin, inulin or xanthan gum. 
     Preferable starch hydrolysates are maltodextrins and dextrins, where here again maltodextrins with DE values in the range 5 to 20 are particularly preferable. Here it is unimportant what plant originally provided the starch for the production of the starch hydrolyzates. Maize-based starches and starches from tapioca, rice, wheat or potatoes in particular are suitable and readily available. Here previously described carrier substances (e.g. silicon dioxide) can advantageously function as free-flow agents. 
     The preparations according to the invention, which as well as one or more compounds of the formula (X) and/or salts thereof or a suitable mixture also contain one or more solid carrier substances can for example be produced by mechanical mixing processes, wherein at the same time a comminution of the particles can take place, or by means of spray-drying. As described above, compositions according to the invention which contain solid carrier substances and are produced by means of spray-drying are preferable; concerning the spray-drying, reference is made to U.S. Pat. No. 3,159,585, U.S. Pat. No. 3,971,852, U.S. Pat. No. 4,532,145 or U.S. Pat. No. 5,124,162. 
     Preferable preparations containing carrier substances (as described above) which have been produced by means of spray-drying preferably have a mean particle size in the range from 30 to 300 μm and preferably a residual moisture content of 5 wt. % or less. 
     According to one embodiment of the present invention, the weight ratio of the total mass of compounds of the formula (X) and optionally of the formula (Y) and salts thereof in a preparation described herein containing one or more (suitable for consumption, solid) carrier substances (as described above) to the total mass of (suitable for consumption, solid) carrier substances preferably lies in the range from 1:10 to 1:100000, preferably in the range from  1:50 (preferably from  1:100) to 1:20000, particularly preferably in the range from 1:100 (preferably from 1:1000) to 1:5000, based on the dry mass of the preparation. 
     In a preparation (as described above) containing one or more (suitable for consumption, solid) carrier substances (as described above), the proportion of the total quantity of compounds of the formula (X) and optionally of the formula (Y), salts thereof and (suitable for consumption, solid) carrier substances, based on the total weight of the preparation, preferably lies in the range from 70 to 100 wt. %, preferably in the range from 85 to 100 wt. %. 
     The preparations according to the invention used for food or enjoyment, as well as normally used animal or plant raw materials, can additionally contain water, squalane or squalene, natural oils (e.g. olive oil, sunflower oil, soya oil, peanut oil, rape oil, almond oil, palm oil, coconut oil, palm nut oil, borage seed oil and more of the like), natural ester oils (e.g. jojoba oil), fats, waxes and other natural fatty substances, carbohydrates, for example glucose, sucrose or lactose, sweeteners, for example aspartame, cyclamate, saccharin, xylitol or sorbitol, bitter substances, for example caffeine or quinine, bitterness-suppressing substances, for example lactisol, flavour-intensifying substances, for example sodium glutamate or inositol phosphate, amino acids, for example glycine, alanine, leucine, isoleucine, valine, proline, lysine, asparagine, aspartic acid, glutamine, glutamic acid, tryptophan, phenylalanine, tyrosine, threonine, serine, cystine, cysteine, methionine, hydroxyproline, arginine or histidine, peptides, proteins, enzymes, fruit acids, preferably lactic acid, malic acid or citric acid, as well as emulsifiers, which can advantageously be selected from the group of the ionic, nonionic, polymeric, phosphatecontaining and zwitterionic emulsifiers, and in particular one or more thickeners, which can advantageously be selected from the group of the polysaccharides or derivatives thereof, e.g. hyaluronic acid, guar gum, carob flour, xanthan gum or allulose derivatives, and natural, nature-identical or synthetic aromas and salts, for example sodium chloride or potassium chloride. 
     The cosmetic and dermatological preparations according to the invention can contain cosmetic auxiliary agents and/or additives such as are normally used in such preparations, e.g. sunscreens (e.g. organic or inorganic light filter substances, preferably micropigments), preservatives, bactericides, fungicides, virucides, cooling active substances, plant extracts, inflammation-inhibiting active substances, wound healing accelerating substances (e.g. chitin or chitosan and derivatives thereof), film-forming substances (e.g. polyvinylpyrrolidones or chitosan or derivatives thereof), common antioxidants, vitamins (e.g. vitamin C and derivatives, tocopherols and derivatives, vitamin A and derivatives), 2-hydroxycarboxylic acids (e.g. citric acid, malic acid, L-, D-, or dl-lactic acid), skin lighteners (e.g. kojic acid, hydroquinone or arbutin), skin colorants (e.g. walnut extracts or dihydroxyacetone), perfumes, substances for prevention of foaming, colorants, pigments which have a colorant action, thickeners, surfactant substances, emulsifiers, plasticizing, moistening and/or humectant substances (e.g. glycerine or urea), fats, oils, unsaturated fatty acids or derivatives thereof (e.g. linolic acid, alpha-linolenic acid, gammalinolenic acid or arachidonic acid and their respective natural or synthetic esters), waxes or other normal components of a cosmetic or dermatological formulation such as alcohols, polyols, polymers, foam stabilizers, electrolytes, organic solvents, silicone derivatives or chelating agents (e.g. ethylendiaminetetraacetic acid and derivatives). 
     The particular quantities to be used can easily be determined by those skilled in the art by simple testing, depending on the nature of the particular product. 
     Preferably preparations according to the invention (as described above) additionally contain one or more antioxidants, where the antioxidant or antioxidants is/are not a compound or compounds of the formula (X) or a salt thereof. In particular, as such antioxidants, all antioxidants suitable or usual for the respective use can be used. The antioxidant or antioxidants is or are preferably selected from the group consisting of amino acids (e.g. glycine, histidine, 3,4-dihydroxyphenylalanine, tyrosine, tryptophan) and derivatives thereof, imidazoles (e.g. urocanic acid) and derivatives thereof, peptides (D,L-carnosine, D-carnosine, L-carnosine, anserine) and derivatives thereof, carotenoids, carotenes (e.g. beta-carotene, alpha-carotene, lycopene) and derivatives thereof, chlorogenic acid and derivatives thereof, lipoic acid and derivatives thereof, aurothioglucose, propylthiouracil and other thiols (e.g. thioredoxin, glutathione, cysteine, cystine, cystamine and glycosyl and N-acyl derivatives thereof or alkyl esters thereof) and salts thereof, dilauryl thiodipropionate, distearyl thiodipropionate, thiodipropionic acid and derivatives thereof and phenolic acid amides of phenolic benzylamines (e.g. homovanillic acid, 3,4-dihydroxyphenylacetic acid, ferulic acid, sinapinic acid, caffeic acid, dihydroferulic acid, dihydrocaffeic acid, vanillomandelic acid- or 3,4-dihydroxymandelic acid amides of 3,4-dihydroxybenzyl, 2,3,4-trihydroxybenzyl- or 3,4,5-trihydroxybenzyl-amine), catechol oximes or catechol oxime ethers (e.g. 3,4-dihydroxybenzaldoxime or 3,4-dihydroxybenzaldehyde Oethyloxime), also (metal) chelators (e.g. 2-hydroxyfatty acids, phytic acid, lactoferrin), humic acid, bile acids, bile extracts, bilirubin, biliverdin, folic acid and derivatives thereof, ubiquinone and ubiquinol and derivatives thereof, vitamin C and derivatives thereof (e.g. ascorbyl palmitate, magnesium ascorbyl phosphate, ascorbyl acetate), tocopherols and derivatives (e.g. alphatocopherol, vitamin E acetate), vitamin A and derivatives (e.g. vitamin A palmitate), rutinic acid and derivatives thereof, flavonoids (e.g. quercetin, alpha-glucosylrutin) and derivatives thereof, phenolic acids (e.g. gallic acid, ferulic acid) and derivatives thereof (e.g. gallic acid propyl ester, ethyl ester and octyl ester), furfurylideneglucitol, dibutylhydroxytoluene, butylhydroxyanisole, uric acid and derivatives thereof, mannose and derivatives thereof, zinc and derivatives thereof (e.g. ZnO, ZnSO 4 ), selenium and derivatives thereof (e.g. selenomethionine), stilbene and derivatives thereof (e.g. stilbene oxide, resveratrol) and the derivatives of these named (active) substances suitable in the context of the present invention. 
     Furthermore, a preparation according to the invention (as described above), in particular a cosmetic or dermatological preparation according to the invention, can include one or more UV-A and/or UV-B filter substances. The filter substance or substances here are preferably selected from the group consisting of 3-benzylidenecamphor derivatives (e.g. 3-(4-methylbenzylidene)-dl-camphor), aminobenzoic acid derivatives (e.g. 4-(N,N-dimethylamino)benzoic acid 2-ethylhexyl ester or menthyl anthranilate), 4-methoxycinnamates (e.g. 2-ethylhexyl p-methoxycinnamate or isoamyl p-methoxycinnamate), benzophenones (e.g. 2-hydroxy-4-methoxybenzophenone), singly or multiply sulphonated UV filters [e.g. 2-phenylbenzimidazol-5-sulphonic acid, sulisobenzone or 1,4-bis(benzimidazolyl)benzene-4,4′,6,6′-tetrasulphonic acid or 3,3′-(1,4-phenylene-dimethylidene)-bis(7,7-dimethyl-2-oxo-bicyclo[2,2,1]heptane-1-methanesulphonic acid) and salts thereof], salicylates (e.g. 2-ethylhexyl salicylate or homomethyl salicylate), triazines {e.g. 2,4-bis-[4-(2-ethylhexyloxy)-2-hydroxyphenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, 4,4′-([6-([(1,1-dimethylethyl)aminocarbonyl]phenylamino)-1,3,5-triazin-2,4-diyl]-diimino)bisbenzoic acid bis-(2-ethylhexyl) ester)}, 2-cyanopropenoic acid derivatives (e.g. 2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate, dibenzoyl derivatives (e.g. 4-tert-butyl-4′-methoxydibenzoylmethane), polymerbound UV filters (e.g. polymers of N-[2-(or 4)-(2-oxo-3-bornylidene)methyl]benzylacrylamide) or pigments (e.g. titanium dioxides, zirconium dioxides, iron oxides, silicon dioxides, manganese oxides, aluminium oxides, cerium oxides or zinc oxides). Such a preparation according to the invention is preferably a sunscreen for skin and/or hair. 
     Accordingly, the present invention particularly preferably relates to a preparation according to the invention (as described above) additionally comprising
     (II) one or more antioxidants, wherein the antioxidant or antioxidants is or are not a compound(s) of the formula (x) or a salt thereof and is or are preferably selected from the group consisting of beta-carotene, lycopene, chlorogenic acid, 2-hydroxy fatty acids, bilirubin, folic acid, ubiquinone, ubiquinol, vitamin C and derivatives thereof, in particular ascorbyl palmitate, magnesium ascorbyl phosphate and ascorbyl acetate; tocopherols and derivatives thereof, in particular alpha-tocopherol and vitamin E acetate; vitamin A and derivatives thereof, in particular vitamin A palmitate; rutinic acid, quercetin, ferulic acid, dibutylhydroxytoluene, butylhydroxyanisole and uric acid, and/or   (III) one or more UV-A and/or UV-B filter substances, where one, several or all of the UV-A and/or UV-B filter substances is or are preferably selected from the group consisting of 3-(4-methylbenzylidene)-dl-camphor, menthyl anthranilate, 2-ethylhexyl p-methoxycinnamate, isoamyl p-methoxycinnamate, 2-hydroxy-4-methoxy-benzophenone, 2-phenylbenzimidazol-5-sulphonic acid and salts thereof, 1,4-bis(benzimidazolyl)benzene-4,4′,6,6′-tetrasulphonic acid and salts thereof, 2-ethylhexyl salicylate, homomenthyl salicylate, 2,4-bis-[4-(2-ethylhexyloxy)-2-hydroxyphenyl]-6-(4-methoxyphenyl)-1,3,5-triazine, 4,4′-([6-([(1,1-dimethylethyl)-amino-carbonyl]phenylamino)-1,3,5-triazin-2,4-diyl]diimino)bisbenzoic acid bis-(2-ethylhexyl) ester), 2-ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate, 4-tert-butyl-4′-methoxydibenzoylmethane, titanium dioxide, silicon dioxide and zinc oxide.   

     Particularly preferable is such a preparation according to the invention, wherein
         the proportion of the total quantity of component (II) in the preparation, based on the total weight of the preparation, is 0.0001 to 30 wt. %, preferably 0.001 to 20 wt. %, particularly preferably 0.001 to 5 wt. %,
 
and/or
   the proportion of the total quantity of component (Ill) in the preparation, based on the total weight of the preparation, is 0.1 to 30 wt. %, preferably 0.5 to 10 wt. %.       

     The (pharmaceutical) preparations in the sense of the present invention used for the treatment of inflammatory states of warm-blooded animals can also be used as semifinished goods for the production of further pharmaceutical preparations used for the treatment of inflammatory states of warm-blooded animals. 
     The pharmaceutical preparations according to the invention used for the treatment of inflammatory states of warm-blooded animals, and corresponding semifinished goods are as a rule products which are intended to be introduced into the body of warm-blooded animals or used on the body of warm-blooded animals. 
     The pharmaceutical preparations according to the invention used for the treatment of inflammatory states of warm-blooded animals in the sense of the present invention are preferably ready-to-use preparations, in particular medicaments and medicinal products, preferably in the following forms: solid galenical forms (such as for example tablets (with and without coating, with and without modified release), sugar-coated tablets (with and without coating, with and without modified release), capsules (soft or hard gelatine capsules with and without modified release) granules (with and without modified release), powders (with and without modified release), suppositories (with and without coating, with and without modified release) lozenges and chewing gums), and liquid forms (such as for example solutions, suspensions, emulsions, syrups (colloquially cough syrup), mouthwashes, gargle solutions, throat sprays or nasal sprays, nasal drops, nasal rinse solutions, nasal powders, nasal ointments or ear drops, ear sprays, ear rinse solutions, ear powders and aural tampons), and semisolid forms (such as for example hydrophobic ointments including for example: hydrocarbon gels, lipogels, silicone gels, oleogels and water-absorbing ointments including for example absorption bases, hydrophilic ointments, hydrophilic gels (hydrogels) or pastes, and inhalants (such as for example compressed gas dispenser inhalers, powder inhalers, inhalers with atomisers, and inhalation concentrates for the preparation of inhalations), and active substance-containing plasters or other therapeutic systems. 
     The pharmaceutical preparations according to the invention can contain (further) pharmaceutical auxiliary and/or additive substances, such as are normally used in such preparations, e.g. active substances from the group of the non-steroidal anti-inflammatories, antibiotics, systemically active steroids, anti-TNF-alpha antibodies or other biotechnologically produced active substances and/or pure substances such as budesonide, sulfasalazine, azathioprine/6-mercaptopurine or methotrexate. And for example fillers (e.g. cellulose, calcium carbonate), free-flow and anticaking agents (e.g. talc, magnesium stearate), coatings (e.g. polyvinyl acetate phthalate, hydroxypropyl-methylcellulose phthalate), disintegrants (e.g. starch, crosslinked polyvinylpyrrolidone), plasticizers (e.g. triethyl citrate, dibutyl phthalate) substances for granulation (lactose, gelatine), retardation (e.g. poly(meth)acrylic acid methyl/ethyl/2-trimethylaminoethyl ester copolymers in dispersion, vinyl acetate/crotonic acid copolymers) and compacting (e.g. microcrystalline cellulose, lactose), solvent, suspension or dispersion agents (e.g. water, ethanol), emulsifiers (e.g. cetyl alcohol, lecithin), substances for modification of the rheological properties (silicon dioxide, sodium alginate), substances for microbial stabilization (e.g. benzalkonium chloride, potassium sorbate), preservatives and antioxidants (e.g. DL-alpha-tocopherol, ascorbic acid), substances for modification of the pH (lactic acid, citric acid), propellant or inert gases (e.g. fluorinated chlorohydrocarbons, carbon dioxide), colorants (iron oxides, titanium dioxide), ointment bases (e.g. paraffins, beeswax), inter alia as described in the technical literature (e.g. Schmidt, Christin. Active and Auxiliary Substances for Individual and Bulk Formulation, and Large-scale Manufacture. 1999; Wissenschaftliche Verlagsgesellschaft mbH Stuttgart or Bauer, Fromming Fuhrer. Textbook of Pharmaceutical Technology. 8 th  Edition, 2006. Wissenschaftliche Verlagsgesellschaft mbH Stuttgart). 
     The particular quantities to be used can easily be determined by those skilled in the art by simple testing, depending on the nature of the particular product. 
     According to one aspect of the present invention, a preparation according to the invention wherein the proportion of the total quantity of compounds of the formula (X) and optionally of the formula (Y) and salts thereof in the preparation lies in the range from 0.0001 to 30 wt. %, preferably in the range from 0.001 to 20 wt. %, and particularly preferably in the range from 0.001 to 5 wt. %, based on the total weight of the preparation, is preferable. 
     (Further) preferable methods for the production of a preferable mixture or preparation according to the invention (as described above) are described below. 
     Such a method preferably comprises the steps
     (a) extraction of plant material (as described above), preferably as described above as preferable, and   (b) concentration of extracted compounds of the formula (X) and optionally additionally of the formula (Y) and/or salts thereof (as described above) by partial or complete removal of other extracted compounds and optionally removal of extractants and/or solvents, preferably so that the proportion of the total quantity of compounds of the formula (X) and optionally (Y) and salts thereof in the mixture obtained, based on the total weight of the mixture, is 0.0001, preferably 15 to 100 wt. %, preferably 25 to 90 wt. % (preferably 100 wt. %), and particularly preferably 45 to 85 wt. % (preferably 100 wt. %).   

     For example, a mixture or preparation according to the invention (as described above) can also be produced by a method according to the invention (as described above), wherein the method is carried out following the method described in the publication in WO2004041804 (for the obtention of a crude extract from  Eriodictyon californicum  and/or  Eriodictyon angustifolium ). 
     The steps of such a method according to the invention (partly based on the method according to WO2004041804) are briefly summarized below:
     (a) Plant material from  Eriodictyon californicum  and/or  Eriodictyon angustifolium  is singly or multiply extracted with a non-water-miscible extractant (optionally with heating up to the relevant boiling point).   (b) The crude extract thus obtained (containing compounds of the formula X and/or of the formula Y to be used according to the invention and other extracted compounds such as for example rosmarinic acid) is separated from the plant material.   (c) The crude extract (containing compounds of the formula X and/or of the formula Y to be used according to the invention and other extracted compounds such as for example rosmarinic acid) is preferably concentrated and interim stocked.   (d) Precipitated solids (waxes) are optionally removed.   (e) The (optionally dewaxed) crude extract (containing compounds of the formula (X) and optionally of the formula (Y) to be used according to the invention and other extracted compounds such as for example rosmarinic acid) is optionally treated with activated charcoal and separated from the solid.   

     Through the following further steps, the compounds of the formula (X) and optionally of the formula (Y) to be used according to the invention can be further concentrated in the organic phase:
     (f) (Preferably complete) removal of the organic solvent of the organic phase by evaporative or permeative methods.   (g) Taking up of the residue (comprising compounds of the formula (X) and optionally of the formula (Y) to be used according to the invention) in methanol.   (h) Removal of the methanol-insoluble components of the mixture (comprising compounds of the formula (X) and optionally of the formula (Y) to be used according to the invention and other extracted compounds) by filtration.   

     In the mixture present according to this method after step e), the proportion of the total quantity of compounds of the formula (X) and optionally of the formula (Y) and salts thereof, based on the dry mass of the mixture (j), according to a preferable embodiment of the present invention lies in the range from 1 to 35 wt. %, preferably in the range from 20 to 35 wt. %. 
     In the mixture (h) present according to this method according to the invention after step h), the proportion of the total quantity of compounds of the formula (X) and optionally of the formula (Y) and salts thereof, based on the dry mass of the mixture (h), preferably lies in the range from 40 to 100 wt. %, preferably in the range from 45 to 85 wt. %. 
     The mixtures (e) and (h) and the mixtures present after the steps f) and g), in particular mixture (h), can each be mixtures according to the invention (as described above). 
     Evaporative or pervaporative methods can for example be distillation, sublimation, steam distillation, freeze drying, pervaporative membrane methods or spray-drying, and particular appropriate auxiliary and/or carrier substances can be added thereto. 
     According to an alternative embodiment of a method according to the invention for the production of a mixture as described above, a methanolic crude extract is obtained from  Eriodictyon  ssp., preferably  Eriodictyon californicum  and/or  Eriodictyon angustifolium , which contains extracted compounds of the formula (X) and optionally of the formula (Y) and other extracted compounds (in particular rosmarinic acid). Herein also, the extracted compounds of the formula (X) and optionally of the formula (Y) and/or salts of these extracted compounds in the mixture are concentrated by partial or complete removal of other extracted compounds and optionally removal of extractants and/or solvents (each time preferably analogously to the previously described method design), so that the proportion of the total quantity of compounds of the formula (X) and optionally of the formula (Y) and salts thereof in the mixture, based on the dry mass of the mixture, for example preferably lies in the range from 40 to 100 wt. %, particularly preferably 45 to 85 wt. %. 
     Such concentration is preferably attained by FCPC (Fast Centrifugal Partition Chromatography, Guido F. Pauli, Samuel M. Pro, J. Brent Friesen Countercurrent Separation of Natural Products  J. Nat. Prod.  2008, 71, 1489-1508) and/or HTLC (High Temperature Liquid Chromatography; WO2006111476) and/or preparative HPLC (High Pressure Liquid Chromatography). 
     According to a preferable embodiment of the present invention, the extracts or mixtures described herein are incorporated in the form of emulsions into liposomes, for example starting from phosphatidylcholine, into microspheres, into nanospheres or also into capsules, granules or extrudates, for example of starch, starch derivates, cellulose or cellulose derivates (for example hydroxypropylcellulose), other polysaccharides (for example alginates), natural fats, natural waxes (for example beeswax, carnauba wax) or of proteins, for example gelatine. 
     In connection with the present invention, a prophylactic and/or therapeutic method as described above, with the following step, is also described: 
     Contacting of (human or animal) tissue and/or of the (human or animal) cells with an inflammation-inhibiting effective quantity of a compound of the formula (X), a salt of a compound of the formula (X), an above-described mixture, in particular of a mixture which additionally comprises a compound of the formula (Y) and/or a salt thereof, as respectively described above, or of a preparation as described above. 
     The contacting of the tissue or the cells with one or more compounds of the formula (X) and optionally additionally one or more compounds of the formula (Y) and/or salts thereof or a mixture or preparation according to the invention (as respectively described above) here—depending on the tissue to be treated or the cells to be treated—can also be effected by external (e.g. topical) or internal use (e.g. oral application). 
     The following examples serve to clarify the invention, without thereby restricting this. 
     EXAMPLES 
     Preparation Examples 
     Example 1 
     Production of a Methanolic Extract from  Eriodictyon angustifolium    
     Boiling water was poured over 500 g of dried leaves of  Eriodictyon angustifolium  and stirred for one hour in order to swell the plant material and prepare it for the further extraction. The plant material was filtered off, dried and extracted twice with 2.01 methanol each time at room temperature for one hour with stirring. The methanolic extract was filtered off, dried under vacuum and stored overnight in the high vacuum drying oven to remove residual solvent. The extraction yielded 84.53 g of dark green extract. 
     Example 2 
     Isolation of the Individual Compounds from  Eriodictyon angustifolium  by Means of FCPC 
     The methanolic extract of  E. angustifolium  according to Example 1 was separated and fractionated by means of FCPC using a two-phase solvent system (heptane/ethyl acetate/methanol/water 5:4:4:5). As well as flavones described in the literature, four compounds of the formula (X) could be isolated. Structure elucidation was effected by means of one- and two-dimensional NMR experiments. The retention times are shown in Table 1, the FCPC conditions in Table 2 and analytical data in Tables 3a and 3b. 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Retention time for various Erionic acids 
               
            
           
           
               
               
               
               
            
               
                   
                   
                 Molecular weight 
                 Retention time 
               
               
                   
                 Compound 
                 [g/mol] 
                 [min] 
               
               
                   
                   
               
               
                   
                 Erionic acid F (6) 
                 358 
                 17.0-19.0 (ascending) 
               
               
                   
                 Erionic acid C (3) 
                 374 
                 64.0-69.0 (ascending) 
               
               
                   
                 Erionic acid A (1) 
                 390 
                 52.0-54.0 (descending) 
               
               
                   
                 Erionic acid B (2) 
                 390 
                 55.0-56.0 (descending) 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2 
               
               
                   
               
               
                 FCPC conditions 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                 FCPC 
                 bench scale FCPC model, version A 
               
               
                   
                 (Kromaton Technologies, Angers, France) 
               
               
                 Rotor 
                 200 ml (semi-preparative) 
               
               
                 Injector 
                 Kronlab High Speed Valve (Kronlab 
               
               
                   
                 Chromatography Technology, Dinslaken) 
               
               
                 Injection loop 
                 10 ml 
               
               
                 Pumps 
                 Knauer HPLC pump 64 (Knauer Berlin) 
               
               
                 Pulse damper 
                 Type 55073 (BESTA-Technik, Wilhelmsfeld) 
               
               
                 Detector 
                 ELSD SEDEX 75 Light scattering detector 
               
               
                   
                 (S.E.D.E.R.E, Alfortville, Cedex, France) 
               
               
                 Fraction collector 
                 Labocol Vario 2000 (Labomatic, Weil am Rhein) 
               
               
                 Software 
                 PrepCon (SCPA GmbH, Weye-Leeste); 
               
               
                   
                 Version 5.03.009, SCPA GmbH 2003 
               
               
                 Solvent system 
                 upper phase: heptane/ethyl acetate (5/4) 
               
               
                   
                 lower phase: methanol/water (4/5) 
               
               
                 Ascending mode 
                 methanol/water as stationary phase 
               
               
                 Descending mode 
                 heptane/ethyl acetate as stationary phase 
               
               
                 Stock solution 
                 60 mg/10 ml stationary/mobile Phase (1:1) 
               
               
                 Flow rate 
                 8 ml/min (ascending mode) 
               
               
                   
                 10 ml/min (descending mode) 
               
               
                 Fractionation 
                 40 fractions of 8 ml (ascending mode) 
               
               
                   
                 30 fractions of 10 ml (descending mode) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 3a 
               
             
            
               
                   
               
               
                 Analytical data 
               
            
           
           
               
               
               
            
               
                   
                 Erionic acid F (6) 
                 Erionic acid C (3) 
               
               
                   
                 (400 MHz, CH3OD) 
                 (400 MHz, CH3OD) 
               
            
           
           
               
               
               
               
               
            
               
                 Pos. 
                 δ c , mult. 
                 δ H  (J in Hz) 
                 δ c , mult. 
                 δ H  (J in Hz) 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 1 
                 123.2 
                   
                 n.d. 
                   
               
               
                 2 
                 130.8 
                 7.63, d (2.1) 
                 131.1 a   
                 6.92, s 
               
               
                 3 
                 129.4 
                   
                 130.3 
               
               
                 4 
                 158.4 
                   
                 158.4 
               
               
                 5 
                 129.4 
                   
                 125.6 
               
               
                 6 
                 130.5 
                 7.71, d (2.1) 
                 130.8 a   
                 6.92, s 
               
               
                 7 
                 170.8 
                   
                 171.1 
               
               
                 8 
                 29.0 
                 2.61, m 
                 29.2 
                 2.59, m 
               
               
                 9 
                 33.8 
                 1.95, m 
                 33.9 
                 1.95, m 
               
               
                   
                   
                 1.61, m 
                   
                 1.61, m 
               
               
                 10 
                 46.2 
                 2.65, m 
                 46.5 
                 2.66, m 
               
               
                 9 
                 33.8 
                 1.95, m 
                 33.9 
                 1.95, m 
               
               
                   
                   
                 1.61, m 
                   
                 1.61, m 
               
               
                 11 
                 216.1 
                   
                 217.4 
               
               
                 12 
                 44.5 
                 3.18, m 
                 42.2 
                 3.19, m 
               
               
                 13 
                 117.2 
                 5.23, dd (7.1, 7.1) 
                 117.5 
                 5.24, m 
               
               
                 14 
                 136.7 
                   
                 136.8 
               
               
                 15 
                 25.9 
                 1.77, s a   
                 25.9 
                 1.72, s 
               
               
                 16 
                 16.9 
                 1.12, d (7.0) 
                 16.9 
                 1.12, d (7.0) 
               
               
                 17 
                 17.9 a   
                 1.72, s a   
                 18.3 
                 1.61, s 
               
               
                 18 
                 29.4 
                 3.33, d (7.3) 
                 29.2 
                 3.40, d (7.4) 
               
               
                 19 
                 123.0 
                 5.32, dd (7.3, 7.3) 
                 124.2 
                 5.61, dd (7.4, 7.4) 
               
               
                 20 
                 134.2 
                   
                 137.8 
               
               
                 21 
                 26.0 
                 1.72, s b   
                 69.1 
                 3.99, s 
               
               
                 22 
                 18.1 a   
                 1.60, s b   
                 13.9 
                 1.76, s 
               
               
                   
               
               
                   a,b interchangeable signals 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 3b 
               
             
            
               
                   
               
               
                 Analytical data 
               
            
           
           
               
               
               
            
               
                   
                 Erionic acid A (1) 
                 Erionic acid B (2) 
               
               
                   
                 (400 MHz, DMSO) 
                 (600 MHz, CH 3 OD) 
               
            
           
           
               
               
               
               
               
            
               
                   
                 δ c , mult. 
                 δ H  (J in Hz) 
                 δ c , mult. 
                 δ H  (J in Hz) 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                 1 
                 127.7 a   
                   
                 130.3 a   
                   
               
               
                 2 
                 128.7 b   
                 7.52, s 
                 130.4 a   
                 7.57, d (2.1) 
               
               
                 3 
                 128.3 a   
                   
                 129.6 a   
               
               
                 4 
                 156.5 
                   
                 155.0 b   
               
               
                 5 
                 121.0 
                   
                 131.4 a   
               
               
                 6 
                 128.9 b   
                 7.52, s 
                 130.4 a   
                 7.56, d (2.1) 
               
               
                 7 
                 169.1 
                   
                 170.2 
               
               
                 8 
                 27.4 
                 2.55, m 
                 28.9 
                 2.58, m 
               
               
                 9 
                 32.6 
                 1.83, m 
                 34.6 
                 1.96, m 
               
               
                   
                   
                 1.51, m 
                   
                 1.61, m 
               
               
                 10 
                 42.7 
                 2.85, ddq 
                 44.4 
                 2.86, ddq 
               
               
                   
                   
                 (6.8, 6.8, 6.8) 
                   
                 (6.8, 6.8, 6.9) 
               
               
                 11 
                 203.4 
                   
                 207.0 
               
               
                 12 
                 123.8 
                 6.27, d (15.8) 
                 125.6 
                 6.29, d (15.8) 
               
               
                 13 
                 154.3 
                 6.83, d (15.8) 
                 154.9 b   
                 6.83, d (15.8) 
               
               
                 14 
                 69.1 
                   
                 71.2 
               
               
                 15 
                 29.0 
                 1.22, s a   
                 29.3 
                 1.30, s a   
               
               
                 16 
                 16.2 
                 1.07, d (6.9) 
                 16.8 
                 1.13, d (6.9) 
               
               
                 17 
                 29.0 
                 1.23, s a   
                 29.3 
                 1.29, s a   
               
               
                 18 
                 27.6 
                 3.33, d (7.3) 
                 32.4 
                 3.02, dd (5.4, 16.5) 
               
               
                   
                   
                   
                   
                 2.74, dd (7.8, 16.5) 
               
               
                 19 
                 120.8 
                 5.50, dd (7.3, 7.3) 
                 70.5 
                 3.75, dd (7.8, 5.4) 
               
               
                 20 
                 136.2 
                   
                 78.4 
               
               
                 21 
                 66.1 
                 3.83, s 
                 24.3 c   
                 1.36, s a   
               
               
                 22 
                 13.1 
                 1.65, s 
                 21.0 c   
                 1.25, s a   
               
               
                   
               
               
                   a,b interchangeable signals 
               
            
           
         
       
     
     Example 3 
     Isolation of the Individual Compounds from  Eriodictyon angustifolium  by Means of High Temperature Liquid Chromatography (HTLC) 
     The methanolic extract of  E. angustifolium  according to Example 1 was separated and fractionated by means of HTLC using a polymer-based semi-preparative column with water-ethanol gradients under isothermal conditions (120° C.). In addition to flavones described in the literature, four substances could be isolated. The results are shown in Table 4, the HTLC conditions in Table 5 and analytical data in Tables 6. 
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 Retention time for various Erionic acids 
               
            
           
           
               
               
               
               
            
               
                   
                   
                 Molecular weight 
                 Retention time 
               
               
                   
                 Compound 
                 [g/mol] 
                 [min] 
               
               
                   
                   
               
               
                   
                 Erionic acid C (3) 
                 374 
                 14.5-15.3 
               
               
                   
                 Erionic acid D (4) 
                 374 
                 15.4-16.5 
               
               
                   
                 Erionic acid E (5) 
                 374 
                 17.0-17.7 
               
               
                   
                 Erionic acid F (6) 
                 358 
                 22.0-23.0 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 5 
               
               
                   
               
               
                 HTLC conditions 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                 Pumps 
                 2 SunChrom HPLC pumps SunFlow 100 (SunChrom, 
               
               
                   
                 Friedrichsdorf, Germany) 
               
               
                 Injector 
                 100 μl loop; Midas, Spark, A J Emmen, 
               
               
                   
                 The Netherlands 
               
               
                 HPLC oven 
                 Polaratherm Series 9000 (Selerity Technologies 
               
               
                   
                 Inc., Salt Lake City, USA) 
               
               
                 Detectors 
                 Light scattering detector (ELSD) Sedex 85 LT-ELSD 
               
               
                   
                 (Sedere, Alfortville, Cedex, France); Diode array 
               
               
                   
                 detector (DAD) SunChrom SpectraFlow, wavelengths 
               
               
                   
                 200-400 nm (SunChrom, Friedrichsdorf, Germany) 
               
               
                 Column 
                 Hamilton PRP-1 reversed phase; 250 × 10 mm 
               
               
                   
                 semi-preparative; 10 μm particle size 
               
               
                   
                 (Hamilton, Bonaduz, Switzerland) 
               
               
                 Flow rate 
                 3 ml/min 
               
               
                 Fraction collector 
                 Labocol Vario 2000 (Labomatic, Weil am Rhein) 
               
               
                 Software 
                 PrepCon (SCPA GmbH, Weye-Leeste); 
               
               
                   
                 Version 5.03.009, SCPA GmbH 2003 
               
               
                 Stock solution 
                 400 mg/ml  E. angustifolium  extract (Y) in 
               
               
                   
                 ethanol/water (1:1) 
               
               
                 Injection volume 
                 100 μl 
               
               
                 Column 
                 Hamilton PRP-1 250 × 10 mm 
               
               
                 Temperature 
                 120° C. isothermal 
               
            
           
           
               
               
               
            
               
                 Eluent 
                 A: water 
                 C: ethanol 
               
            
           
           
               
               
               
               
            
               
                 Gradient 
                  0 min: 
                 100% A  
                  0% C 
               
               
                   
                 30 min: 
                 50% A  
                  50% C 
               
               
                   
                 50 min: 
                 0% A 
                 100% C 
               
               
                   
                 60 min: 
                 0% A 
                 100% C 
               
            
           
           
               
               
            
               
                 Detection 
                 ELSD (3.5 bar N2, 45° C., gain 6); DAD 210 nm, 
               
               
                   
                 250 nm, 280 nm, 320 nm 
               
               
                   
               
            
           
         
       
     
     The following analytical data for erionic acid C (3) and erionic acid F (6) correspond to those stated in Example 2. 
     
       
         
           
               
             
               
                 TABLE 6 
               
             
            
               
                   
               
               
                 Analytical data 
               
            
           
           
               
               
               
            
               
                   
                 Erionic acid D (4) 
                 Erionic acid E (5) 
               
               
                   
                 (400 MHz, CH3OD) 
                 (400 MHz, CH 3 OD) 
               
            
           
           
               
               
               
               
               
            
               
                 Pos. 
                 δ c , mult. 
                 δ H  (J in Hz) 
                 δ c , mult. 
                 δ H  (J in Hz) 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 1 
                 130.6 a   
                   
                 123.3 
                   
               
               
                 2 
                 130.6 a   
                 7.60, d (2.2) 
                 131.0 a   
                 7.60, d (2.2) 
               
               
                 3 
                 130.6 a   
                   
                 130.3 
               
               
                 4 
                 156.2 
                   
                 158.1 
               
               
                 5 
                 120.9/120.8 
                   
                 128.9 
               
               
                 6 
                 131.3 
                 7.61, d (2.2) 
                 130.8 a   
                 7.63, d (2.2) 
               
               
                 7 
                 171.0 
                   
                 171.5 
               
               
                 8 
                 28.9/28.8 
                 2.56, m 
                 29.3 
                 2.62, m 
               
               
                 9 
                 34.0/34.0 
                 1.94, m 
                 34.4 
                 1.97, m 
               
               
                   
                   
                 1.60, m 
                   
                 1.63, m 
               
               
                 10 
                 46.3/46.3 
                 2.63, m 
                 44.5 
                 2.89, ddq 
               
               
                   
                   
                   
                   
                 (6.9, 6.9, 6.9) 
               
               
                 11 
                 215.6/215.5 
                   
                 207.1 
               
               
                 12 
                 41.9 
                 3.17, m 
                 125.8 
                 6.34, d (15.9) 
               
               
                 13 
                 117.3 
                 5.23, m 
                 155.5 
                 6.88, d (15.9) 
               
               
                 14 
                 136.6 
                   
                 71.2 
               
               
                 15 
                 25.9 
                 1.72, s 
                 29.3 
                 1.31, s 
               
               
                 16 
                 16.7 
                 1.11, d (6.9) 
                 17.2 
                 1.15, d (7.0) 
               
               
                 17 
                 18.3 
                 1.60, s 
                 29.3 
                 1.31, s 
               
               
                 18 
                 32.2 
                 3.05/3.06, dd/dd 
                 29.7 
                 3.31 (masked by 
               
               
                   
                   
                 (16.7, 5.2) 
                   
                 solvents), 
               
               
                   
                   
                 2.76, dd (16.6, 7.2) 
               
               
                 19 
                 70.0/70.0 
                 3.78, m 
                 123.4 
                 5.33, dd (7.4, 7.4) 
               
               
                 20 
                 79.1/79.1 
                   
                 134.5 
               
               
                 21 
                     26.1/26.0 b   
                 1.37/1.36 a   
                 26.2 
                 1.77, s 
               
               
                 22 
                     21.6/21.3 b   
                 1.30/1.29 a   
                 18.0 
                 1.71, s 
               
               
                   
               
               
                   a,b interchangeable signals 
               
            
           
         
       
     
     Example 4 
     Production of a Extract of Erionic Acid from  E. angustifolium  by Means of Gel Permeation Chromatography 
     From 0.5 g of the methanolic extract of  E. angustifolium  according to Example 1, the flavanones were removed with a flow rate of 2.5 ml/min over a Sephadex-LH 20 column. After evaporation an extract (“FF”) rich in flavonoids was obtained. The remaining part was dried under vacuum and stored overnight in the high vacuum drying oven to remove residual solvent. The flavonoidfree dry extract thus obtained had a content of 46% of benzoic acid derivatives to be used according to the invention. 
     Gel Permeation Chromatography Conditions 
     
         
         Stock solution: 0.5 g/20 ml methanol 
         Column: Kronlab 3.5×60 cm 
         Column material: Sephadex LH-20 
         Solvent: Methanol 
         Flow rate: 2.5 ml/min 
         Detection (UV): 210 nm 
       
    
       FIG. 1  shows typical LC-MS chromatograms (a) of the extract rich in erionic acid thus obtained and (b) of the extract rich in flavonoids respectively. 
     Example 5 
     Production of a Methanolic Extract from  Eriodictyon californicum    
     Boiling water was poured over 150 g of dried leaves of  Eriodictyon californicum  and stirred for one hour in order to swell the plant material and prepare it for the further extraction. The plant material was filtered off, dried and extracted twice with 1.5 l of methanol each time at room temperature for one hour with stirring. The extract was filtered, dried under vacuum and stored overnight in the high vacuum drying oven to remove residual solvent. The extraction yielded 32.65 g of dark green extract. 
     Example 6 
     Isolation Of the Individual Compounds from  Eriodictyon californicum  by Means of HTLC 
     The methanolic extract of  E. californicum  according to Example 5 was separated and fractionated by means of HTLC using a polymer-based semi-preparative column with water-ethanol gradients under isothermal conditions (120° C.). In addition to flavones known from the literature, four compounds of the formula (X) could be isolated. The results are shown in Table 7, the HTLC conditions in Table 8 and analytical data in Tables 9a and 9b. 
     
       
         
           
               
             
               
                 TABLE 7 
               
             
            
               
                   
               
               
                 Retention time for various Eriolic acids 
               
            
           
           
               
               
               
               
            
               
                   
                   
                 Molecular weight 
                 Retention time 
               
               
                   
                 Compound 
                 [g/mol] 
                 [min] 
               
               
                   
                   
               
               
                   
                 Eriolic acid A (7) 
                 388 
                 15.0-16.5 
               
               
                   
                 Eriolic acid B (8) 
                 358 
                 21.0-22.9 
               
               
                   
                 Eriolic acid C (9) 
                 374 
                 13.5-14.8 
               
               
                   
                 Eriolic acid D (10) 
                 372 
                 20.0-21.0 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 8 
               
               
                   
               
               
                 HTLC conditions 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                 Pumps 
                 2 SunChrom HPLC pumps SunFlow 100 (SunChrom, 
               
               
                   
                 Friedrichsdorf, Germany) 
               
               
                 Injector 
                 100 μl loop; Midas, Spark, A J Emmen, 
               
               
                   
                 The Netherlands 
               
               
                 HPLC oven 
                 Polaratherm Series 9000 (Selerity Technologies 
               
               
                   
                 Inc., Salt Lake City, USA) 
               
               
                 Detectors 
                 Light scattering detector (ELSD) Sedex 85 LT-ELSD 
               
               
                   
                 (Sedere, Alfortville, Cedex, France); Diode array 
               
               
                   
                 detector (DAD) SunChrom SpectraFlow, wavelengths 
               
               
                   
                 200-400 nm (SunChrom, Friedrichsdorf, Germany) 
               
               
                 Column 
                 Hamilton PRP-1 reversed phase; 250 × 10 mm 
               
               
                   
                 semi-preparative; 10 μm particle size 
               
               
                   
                 (Hamilton, Bonaduz, Switzerland) 
               
               
                 Flow rate 
                 3 ml/min 
               
               
                 Fraction collector 
                 Labocol Vario 2000 (Labomatic, Weil am Rhein) 
               
               
                 Software 
                 PrepCon (SCPA GmbH, Weye-Leeste); 
               
               
                   
                 Version 5.03.009, SCPA GmbH 2003 
               
               
                 Stock solution 
                 300 mg/ml  E. californicum  extract (Y) in 
               
               
                   
                 ethanol/water (1:1) 
               
               
                 Injection volume 
                 100 μl 
               
               
                 Column 
                 Hamilton PRP-1 250 × 10 mm 
               
               
                 Temperature 
                 120° C. isothermal 
               
            
           
           
               
               
               
            
               
                 Eluent 
                 A: water 
                 C: ethanol 
               
            
           
           
               
               
               
               
            
               
                 Gradient 
                  0 min: 
                 100% A  
                  0% C 
               
               
                   
                 30 min: 
                 50% A  
                  50% C 
               
               
                   
                 50 min: 
                 0% A 
                 100% C 
               
               
                   
                 60 min: 
                 0% A 
                 100% C 
               
            
           
           
               
               
            
               
                 Detection 
                 ELSD (3.5 bar N2, 45° C., gain 6); DAD 210 nm, 
               
               
                   
                 250 nm, 280 nm, 320 nm 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 9a 
               
             
            
               
                   
               
               
                 Analytical data 
               
            
           
           
               
               
               
            
               
                   
                 Eriolic acid A (7) 
                 Eriolic acid B (8) 
               
               
                   
                 (400 MHz, CH3OD) 
                 (400 MHz, CH 3 OD) 
               
            
           
           
               
               
               
               
               
            
               
                 Pos. 
                 δ c , mult. 
                 δ H  (J in Hz) 
                 δ c , mult. 
                 δ H  (J in Hz) 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 1 
                 129.6 
                   
                 123.1 
                   
               
               
                 2 
                 131.0 
                 7.72, s 
                 130.3 
                 7.64, d (2.2) 
               
               
                 3 
                 135.7 
                   
                 128.8 
               
               
                 4 
                 161.4 
                   
                 158.2 
               
               
                 5 
                 135.7 
                   
                 129.2 
               
               
                 6 
                 130.9 
                 7.72, s 
                 130.3 
                 7.63, d (2.2) 
               
               
                 7 
                 170.6 
                   
                 170.9 
               
               
                 8 
                 28.8 b   
                 3.43, d (7.1) 
                 29.0 
                 3.38, d (7.4) 
               
               
                 9 
                 125.5 
                 5.50, dd (7.2, 7.2) 
                 124.9 
                 5.50, dd (7.4, 7.4) 
               
               
                 10 
                 139.6 
                   
                 139.6 
               
               
                 11 
                 78.6 
                 3.98, dd (7.0, 7.0) 
                 78.7 
                 3.99, dd (7.0, 7.0) 
               
               
                 12 
                 34.8 
                 2.26, dd (7.0, 7.0) 
                 34.8 
                 2.26, dd (7.0, 7.0) 
               
               
                 13 
                 121.7 
                 5.07, dd (7.0, 7.0) 
                 121.7 
                 5.08, dd (7.0, 7.0) 
               
               
                 14 
                 134.0 
                   
                 134.0 
               
               
                 15 
                 26.0 
                 1.63, s 
                 26.0 
                 1.64, s 
               
               
                 16 
                 11.8 
                 1.74, s 
                 11.6 
                 1.72, s 
               
               
                 17 
                 18.0 
                 1.60, s 
                 17.9 a   
                 1.59, s 
               
               
                 18 
                 28.9 a   
                 3.45, d (7.1) 
                 29.4 
                 3.33, d (7.1) 
               
               
                 19 
                 124.5 
                 5.57, dd (7.3, 7.3) 
                 123.0 
                 5.32, dd (7.3, 7.3) 
               
               
                 20 
                 137.5 
                   
                 134.1 
               
               
                 21 
                 68.7 
                 3.98, s 
                 26.0 
                 1.76, s 
               
               
                 22 
                 13.9 
                 1.78, s 
                 18.0 a   
                 1.72, s 
               
               
                 23 
                 61.6 
               
               
                   
               
               
                   a,b  interchangeable signals 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 9b 
               
             
            
               
                   
               
               
                 Analytical data 
               
            
           
           
               
               
               
            
               
                   
                 Eriolic acid C (9) 
                 Eriolic acid D (10) 
               
               
                   
                 (400 MHz, CH3OD) 
                 (400 MHz, CH 3 OD) 
               
            
           
           
               
               
               
               
               
            
               
                 Pos. 
                 δ c , mult. 
                 δ H  (J in Hz) 
                 δ c  mult. 
                 δ H  (J in Hz) 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 1 
                 123.4 
                   
                 128.4 
                   
               
               
                 2 
                 130.4 
                 7.65, s 
                 130.8 
                 7.71, d (2.2) 
               
               
                 3 
                 128.8 
                   
                 135.5 
               
               
                 4 
                 158.1 
                   
                 161.3 
               
               
                 5 
                 128.8 
                   
                 136.1 
               
               
                 6 
                 130.4 
                 7.65, s 
                 130.8 
                 7.70, d (2.2) 
               
               
                 7 
                 171.1 
                   
                 170.7 
               
               
                 8 
                 29.1 a   
                 3.38, d (7.2) 
                 28.8 
                 3.43, d (7.3) 
               
               
                 9 
                 124.7 
                 5.55, dd (7.4, 7.4) 
                 125.5 
                 5.50, dd (7.2, 7.2) 
               
               
                 10 
                 139.6 
                   
                 139.5 
               
               
                 11 
                 78.6 
                 3.99, dd (7.1, 7.1) 
                 78.6 
                 3.98, dd (7.0, 7.0) 
               
               
                 12 
                 34.8 
                 2.26, dd (7.1, 7.1) 
                 34.8 
                 2.26, dd (7.0, 7.0) 
               
               
                 13 
                 121.6 
                 5.09, dd (7.1, 7.1) 
                 121.6 
                 5.06, dd (7.0, 7.0) 
               
               
                 14 
                 134.0 
                   
                 133.9 
               
               
                 15 
                 26.0 
                 1.64, s 
                 26.0 a   
                 1.63, s 
               
               
                 16 
                 11.6 
                 1.72, s 
                 11.7 
                 1.74, s 
               
               
                 17 
                 18.0 
                 1.60, s 
                 18.0 b   
                 1.59, s 
               
               
                 18 
                 28.9 a   
                 3.40, d (7.4) 
                 29.2 
                 3.38, d (7.3) 
               
               
                 19 
                 124.1 
                 5.61, dd (7.4, 7.4) 
                 123.7 
                 5.28, dd (7.3, 7.3) 
               
               
                 20 
                 137.4 
                   
                 133.9 
               
               
                 21 
                 68.8 
                 3.99, s 
                 25.9 a   
                 1.75, s 
               
               
                 22 
                 13.8 
                 1.76, s 
                 17.9 b   
                 1.74, s 
               
               
                 23 
                   
                   
                 61.5 
                 3.76, s 
               
               
                   
               
               
                   a,b interchangeable signals 
               
            
           
         
       
     
     Example 7 
     Production of a Concentrated Extract from  Eriodictyon californicum  by Means of Precipitation 
     5.0 g of an extract of  E. californicum  prepared analogously to Example 5 were dissolved in 100 ml ethyl acetate. By addition of 10 ml of 3% sodium hydroxide solution with stirring, the homoeriodictyol contained was precipitated out. The remaining solution was dried over sodium sulphate and concentrated. The sterubin also contained in the extract was precipitated out by storage of the extract in the refrigerator for 12 hours. After filtration, the filtrate was dried under vacuum and stored overnight in the high vacuum drying oven to remove residual solvent. The flavonoid-depleted dry extract thus obtained contained benzoic acid derivatives to be used according to the invention in a proportion of 50%. 
     Example 8 
     Production of a Concentrated Extract from  E. californicum  by Means of Gel Permeation Chromatography 
     From 0.5 g of the methanolic extract of  E. californicum  according to Example 5, the flavanoids were removed with a flow rate of 2.5 ml/min over a Sephadex-LH 20 column, and the remaining extract dried under vacuum and stored overnight in the high vacuum drying oven to remove residual solvent. The purified dry extract thus obtained had a content of the benzoic acid derivates to be used according to the invention of 75%.
     Stock solution: 0.5 g/20 ml methanol   Column: Kronlab 3.5×60 cm   Column material: Sephadex LH-20   Solvent: Methanol   Flow rate: 2.5 ml/min   Detection (UV): 210 nm   

     Example 9 
     Production of a Concentrated Extract by Means of Gel Permeation Chromatography 
     An extract prepared according to WO2004041804 which had already been depleted of homoeriodictyol and sterubin by the method described therein was fractionated over a Sephadex LH-20 column analogously to Example 4 to remove the residual flavonoids, dried under vacuum and stored overnight in the high vacuum drying oven to remove residual solvent. The flavanoidfree dry extract thus obtained had a content of the benzoic acid derivatives to be used according to the invention of 62%. 
     Formulation Examples 
     The following tables show formulation examples comprising the products of the present invention. 
     
       
         
           
               
             
               
                 TABLE I 
               
             
            
               
                   
               
               
                 Low-fat yoghurt, sweetened (Amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredient 
                 A 
                 B 
                 C 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Sucrose 
                 10 
                 8 
                 6 
               
               
                 Tagatose 
                 — 
                 — 
                 0.5 
               
               
                 Fructose 
                 — 
                 — 
                 0.05 
               
               
                 Hesperetin 
                 — 
                 0.1 
                 0.005 
               
               
                 Phloretin 
                 — 
                 — 
                 0.005 
               
               
                 Strawberry flavour 
                 — 
                 0.25 
                 — 
               
               
                 Peach flavour 
                 0.3 
                 — 
                 0.4 
               
               
                 Herba Santa extract ( E. angustifolium ) 
                 0.4 
                 0.4 
               
               
                 as per Example 1 (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract ( E. angustifolium ) 
                   
                   
                 0.1 
               
               
                 as per Ex. 4 (10% in ethanol) 
               
            
           
           
               
               
            
               
                 Yoghurt, 0.1% fat 
                 Ad 100 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE II 
               
             
            
               
                   
               
               
                 Low fat yoghurt, reduced sugar (amounts in % b.w.) 
               
            
           
           
               
               
               
               
               
            
               
                 Ingredient 
                 A 
                 B 
                 C 
                 D 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Tagatose 
                 0.482 
                 0.482 
                 0.482 
                   
               
               
                 Sucralose 
                 0.003 
                 0.003 
                 0.003 
               
               
                 Aspartame 
                 0.00 
                 0.00 
                 0.00 
               
               
                 Acesulfam K 
                 0.01 
                 0.01 
                 0.01 
               
               
                 Rebaudioside A 
                   
                   
                   
                 0.00 
               
               
                   Rubus suavissimus  extract 
                   
                   
                   
                 0.00 
               
               
                 Hesperetin 
                   
                 0.01 
                 0.00 
                 0.00 
               
               
                 Phloretin 
                 — 
                 — 
                 0.00 
                 0.00 
               
               
                 Strawberry flavour 
                 — 
                 0.2 
                 — 
                 0.2 
               
               
                 Raspberry flavour 
                 0.3 
                 — 
                 0.4 
               
               
                 Herba Santa extract ( E. californicum ) 
                 0.3 
                   
                   
                 0.4 
               
               
                 as per Ex. 5 (10% in ethanol) 
               
               
                 Concentrated Herba Santa 
                   
                 0.1% 
                 0.1% 
               
               
                 extract ( E. californicum ) 
               
               
                 as per Ex. 8 (10% in ethanol) 
               
            
           
           
               
               
            
               
                 Yoghurt, 0.1% fat 
                 Ad 100 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE III 
               
             
            
               
                   
               
               
                 Low fat yoghurt drink, sweetened (amounts in % b.w.) 
               
            
           
           
               
               
               
               
               
            
               
                   
                 Ingredient 
                 A 
                 B 
                 C 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 Sucrose 
                 7 
                 4 
                 5 
               
               
                   
                 Tagatose 
                 — 
                 — 
                 0.5 
               
               
                   
                 Fructose 
                 — 
                 — 
                 0.05 
               
               
                   
                 Hesperetin 
                 — 
                 0.1 
                 0.005 
               
               
                   
                 Phloretin 
                 — 
                 — 
                 0.005 
               
               
                   
                 Strawberry flavour 
                 — 
                 0.15 
                 — 
               
               
                   
                 Red fruit flavour 
                 0.2 
                 — 
                 0.25 
               
               
                   
                 Colouring food: fruit juice 
                 5 
                 5 
                 5 
               
               
                   
                 Herba Santa extract 
                 0.35 
                 0.2 
               
               
                   
                 ( E. angustifolium ) as per 
               
               
                   
                 Example 1 (10% in ethanol) 
               
               
                   
                 Concentrated Herba Santa 
                   
                   
                 0.15 
               
               
                   
                 extract ( E. angustifolium ) 
               
               
                   
                 as per Ex. 4 (10% in ethanol) 
               
               
                   
                 Yoghurt, 0.1% fat 
                 60 
                 60 
                 60 
               
            
           
           
               
               
               
            
               
                   
                 Water 
                 Ad 100 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE IV 
               
             
            
               
                   
               
               
                 Sugar-free hard caramels (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                   
                 Ingredient 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Palatinit, type M 
                 Ad 100 
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Water 
                 24.82 
                 24.82 
               
               
                   
                 Peppermint flavour 
                 0.15 
                 0.05 
               
               
                   
                 Hesperetin 
                   
                 0.10 
               
               
                   
                 Trans-pellitorin (10% in ethanol) 
                 0.01 
               
               
                   
                 Herba Santa extract 
                 0.1 
               
               
                   
                 ( E. angustifolium ) as per 
               
               
                   
                 Ex. 1 (10% in ethanol) 
               
               
                   
                 Concentrated Herba Santa 
                   
                 0.05 
               
               
                   
                 extract ( E. angustifolium ) 
               
               
                   
                 as per Ex. 4 (10% in ethanol) 
               
               
                   
                   
               
            
           
         
       
     
     Palatinit was mixed with water and the mixture was melted at 165° C. then cooled to 115° C. Flavouring and extract produced according to the invention, and trans-pellitorin in case A and hesperetin in case B, were added, and after thorough mixing poured into moulds, and after solidification were removed from the foil and then individually packed. 
     
       
         
           
               
             
               
                 TABLE V 
               
             
            
               
                   
               
               
                 Black, green or herb tea (amounts in % b.w.) 
               
            
           
           
               
               
               
               
               
               
            
               
                 Ingredient 
                 A 
                 B 
                 C 
                 D 
                 E 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Black tea (Ceylon) leaves 
                 99.4 
                 — 
                 — 
                 — 
                 — 
               
               
                 Green tea (China), leaves 
                 — 
                 99.2 
                 — 
                 — 
                 — 
               
               
                 Mate tea (Peru), leaves 
                 — 
                 — 
                 99.5 
                 — 
               
               
                 Rooibos tea (South Africa), leaves 
                 — 
                 — 
                 — 
                 99.6 
                 — 
               
               
                 Honeybush tea (South Africa), leaves 
                 — 
                 — 
                 — 
                 — 
                 99.6 
               
               
                 Herba Santa extract 
                 0.3 
                 0.8 
                 — 
                 0.4 
                 0.2 
               
               
                 ( E. angustifolium ) as per Ex. 1 
               
               
                 Herba Santa extract 
                 0.3 
                 — 
                 0.5 
                 — 
                 0.2 
               
               
                 ( E. californicum ) as per Ex. 5 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE VI 
               
             
            
               
                   
               
               
                 Soya drink 
               
            
           
           
               
               
               
               
               
            
               
                   
                 Ingredient 
                 A 
                 B 
                 C 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 Sucrose 
                 5 
                 5 
                 3.5 
               
               
                   
                 Tagatose 
                 — 
                 — 
                 0.5 
               
               
                   
                 Fructose 
                 — 
                 — 
                 0.05 
               
               
                   
                 Hesperetin 
                 — 
                 — 
                 0.005 
               
               
                   
                 Phloretin 
                 — 
                 — 
                 0.005 
               
               
                   
                 Chocolate flavour 
                 — 
                 0.15 
                 — 
               
               
                   
                 Vanilla flavour 
                 0.1 
                 — 
                 0.1 
               
               
                   
                 Herba Santa extract 
                 0.08 
                 0.1 
               
               
                   
                 ( E. angustifolium ) as per 
               
               
                   
                 Example 1 (10% in ethanol) 
               
               
                   
                 Concentrated Herba Santa 
                   
                   
                 0.05 
               
               
                   
                 extract ( E. californicum ) 
               
               
                   
                 as per Ex. 8 (10% in ethanol) 
               
            
           
           
               
               
               
            
               
                   
                 Unsweetened soya milk base 
                 Ad 100 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE VII 
               
             
            
               
                   
               
               
                 Fruity muesli bars (amounts in % b.w.) 
               
            
           
           
               
               
               
            
               
                   
                 Ingredients 
                 A 
               
               
                   
                   
               
            
           
           
               
               
               
            
               
                   
                 Saccharose 
                 15.992 
               
               
                   
                 Glucose syrup 
                 14.0 
               
               
                   
                 Sorbitol P300 
                 5.0 
               
               
                   
                 Plant fat 
                 5.0 
               
               
                   
                 Water 
                 3.0 
               
               
                   
                 Rolled oats 
                 7.3 
               
               
                   
                 Oat flakes 
                 7.0 
               
               
                   
                 Cornflakes 
                 4.5 
               
               
                   
                 Rice crispies 
                 15.0 
               
               
                   
                 Currants 
                 3 
               
               
                   
                 Dried blueberries 
                 20 
               
               
                   
                 Citric acid powder 
                 0.2 
               
               
                   
                 Concentrated Herba Santa extract as per Ex. 4 
                 0.008 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE VIII 
               
             
            
               
                   
               
               
                 Chewing gum for bad breath (amounts in % b.w.) 
               
            
           
           
               
               
               
               
               
            
               
                 Ingredients 
                 A 
                 B 
                 C 
                 D 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Chewing gum base 
                 21.00 
                 21.00 
                 21.00 
                 21.00 
               
               
                 Glucose syrup 
                 16.80 
                 16.80 
                 16.50 
                 16.50 
               
               
                 Glycerine 
                 0.50 
                 0.50 
                 0.50 
                 0.50 
               
               
                 Sugar powder 
                 60.00 
                 60.00 
                 60.40 
                 60.40 
               
               
                 Spearmint flavour 
                 1.50 
                 1.50 
                 1.50 
                 1.50 
               
               
                 Herba Santa extract ( E. angustifolium ) 
                 0.2 
               
               
                 as per Ex. 1 10% in ethanol 
               
               
                 Herba Santa extract ( E. californicum ) 
                   
                 0.2 
               
               
                 as per Ex. 5 10% in ethanol 
               
               
                 Concentrated extract from  E. angustifolium   
                   
                   
                 0.1 
               
               
                 as per Ex. 4 - 10% in ethanol 
               
               
                 Concentrated extract from  E. californicum   
                   
                   
                   
                 0.1 
               
               
                 as per Ex. 7 - 10% in ethanol 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE IX 
               
             
            
               
                   
               
               
                 Sugar-free chewing gum for bad breath (amounts in % b.w.) 
               
            
           
           
               
               
               
               
               
            
               
                 Ingredients 
                 A 
                 B 
                 C 
                 D 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Chewing gum base 
                 30.00 
                 30.00 
                 30.00 
                 30.00 
               
               
                 Sorbitol, powder 
                 38.25 
                 38.25 
                 38.40 
                 38.40 
               
               
                 Palatinit 
                 9.50 
                 9.50 
                 9.50 
                 9.50 
               
               
                 Xylitol 
                 2.00 
                 2.00 
                 2.00 
                 2.00 
               
               
                 Mannitol 
                 3.00 
                 3.00 
                 3.00 
                 3.00 
               
               
                 Aspartame 
                 0.10 
                 0.10 
                 0.10 
                 0.10 
               
               
                 Acesulfam K 
                 0.10 
                 0.10 
                 0.10 
                 0.10 
               
               
                 Emulgum/emulsifier 
                 0.30 
                 0.30 
                 0.30 
                 0.30 
               
               
                 Sorbitol 70%, in water 
                 14.00 
                 14.00 
                 14.00 
                 14.00 
               
               
                 Glycerine 
                 1.00 
                 1.00 
                 1.00 
                 1.00 
               
               
                 Cinnamon/menthol flavour 
                 1.50 
                 1.50 
                 1.50 
                 1.50 
               
               
                 Herba Santa extract ( E. angustifolium ) 
                 0.25 
               
               
                 as per Ex. 1 - 10% in ethanol 
               
               
                 Herba Santa extract ( E. californicum ) 
                   
                 0.2 
               
               
                 as per Ex. 5 - 10% in ethanol 
               
               
                 Concentrated extract from  E. angustifolium   
                   
                   
                 0.1 
               
               
                 as per Ex. 4 - 10% in ethanol 
               
               
                 Concentrated extract from  E. californicum   
                   
                   
                   
                 0.1 
               
               
                 as per Ex. 7 - 10% in ethanol 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE X 
               
             
            
               
                   
               
               
                 Ready-to-use mouthwash solution with fluoride 
               
               
                 for bad breath (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredients 
                 A 
                 B 
                 C 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Ethanol 
                 7.00 
                 7.00 
                 7.00 
               
               
                 Glycerine 
                 12.00 
                 12.00 
                 12.00 
               
               
                 Na fluoride 
                 0.05 
                 0.05 
                 0.05 
               
               
                 Pluronic F-127 ® (BASF, 
                 1.40 
                 1.40 
                 1.40 
               
               
                 surface-active substance) 
               
               
                 Na phosphate buffer pH 7.0 
                 1.10 
                 1.10 
                 1.10 
               
               
                 Sorbic acid 
                 0.20 
                 0.20 
                 0.20 
               
               
                 Na saccharinate 
                 0.10 
                 0.10 
                 0.10 
               
               
                 Cinnamon/menthol flavour 
                 0.15 
                 0.15 
                 0.15 
               
               
                 Herba Santa extract ( E. angustifolium ) 
                 0.3 
               
               
                 as per Ex. 1 10% in ethanol 
               
               
                 Herba Santa extract ( E. californicum ) 
                   
                 0.3 
               
               
                 as per Ex. 5 10% in ethanol 
               
               
                 Concentrated extract from  E. angustifolium   
                   
                   
                 0.08 
               
               
                 as per Ex. 4 10% in ethanol 
               
               
                 Colorant 
                 0.01 
                 0.01 
                 0.01 
               
            
           
           
               
               
            
               
                 Dist. water 
                 Ad 100 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XI 
               
             
            
               
                   
               
               
                 Mouthwash solution (concentrate) for 
               
               
                 bad breath (amounts in % b.w.) 
               
            
           
           
               
               
               
               
               
            
               
                   
                 Ingredients 
                 A 
                 B 
                 C 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 Ethanol, 95% 
                 80.00 
                 80.00 
                 80.00 
               
               
                   
                 Na cyclamate 
                 0.15 
                 0.15 
                 0.15 
               
               
                   
                 Eucalyptus/wintergreen flavour 
                 3.50 
                 3.50 
                 3.50 
               
               
                   
                 Colorant 
                 0.01 
                 0.01 
                 0.01 
               
               
                   
                 Herba Santa extract 
                 0.50 
               
               
                   
                 ( E. angustifolium ) as per Ex. 1 
               
               
                   
                 Concentrated extract from 
                   
                 0.1 
               
               
                   
                   E. angustifolium  as per Ex. 4 
               
               
                   
                 Concentrated extract from 
                   
                   
                 0.1 
               
               
                   
                   E. californicum  as per Ex. 7 
               
            
           
           
               
               
               
            
               
                   
                 Demin. water 
                 Ad 100 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XII 
               
             
            
               
                   
               
               
                 Mouthwash solution with fluoride for 
               
               
                 bad breath (amounts in % b.w.) 
               
            
           
           
               
               
               
            
               
                 Ingredient 
                 INCI 
                 A 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Ethyl alcohol 
                 Ethyl alcohol 
                 10.00 
               
               
                 Cremophor CO 40 
                 Cremophor CO 40 (PEG 
                 1.00 
               
               
                   
                 40 hydrogenated castor oil) 
               
               
                 Benzoic acid 
                 Benzoic acid 
                 0.12 
               
               
                 Aroma (PF1, PF2, PF3 or PF4) 
                 Flavour 
                 0.25 
               
               
                 Demin. water 
                 Water (deionized) 
                 83.28 
               
               
                 Sorbitol 70% 
                 Sorbitol 70% 
                 5.00 
               
               
                 Sodium saccharin 
                 Sodium saccharin 450 
                 0.07 
               
               
                 Sodium fluoride 
                 Sodium fluoride 
                 0.18 
               
            
           
           
               
               
            
               
                 Herba Santa extract ( E. angustifolium ) 
                 0.10 
               
               
                 as per Ex. 1 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XIII 
               
             
            
               
                   
               
               
                 Toothpaste (amounts in % b.w.) 
               
            
           
           
               
               
               
            
               
                 Ingredient 
                 INCI 
                 A 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Demin. water 
                 Water (deionized) 
                 26.31 
               
               
                 Sorbitol 70% 
                 Sorbitol 70% 
                 70.0 
               
               
                 Solbrol M (Na salt) 
                 Solbrol M (Sodium salt) 
                 0.15 
               
               
                   
                 (methylparaben) 
               
               
                 Trisodium phosphate 
                 Trisodium phosphate 
                 0.10 
               
               
                 Saccharin 
                 Saccharin 
                 0.20 
               
               
                 Sodium 
                 Sodium monofluorophosphate 
                 1.14 
               
               
                 monofluorophosphate 
               
               
                 PEG 1500 
                 PEG 1500 
                 5.00 
               
               
                 Sident 9 (abrasive silica gel) 
                 Sident 9 (abrasive silica) 
                 10.00 
               
               
                 Sident 22 S (thickener) 
                 Sident 22 S (thickening silica) 
                 8.00 
               
               
                 Sodium 
                 Sodium carboxymethylcellulose 
                 1.10 
               
               
                 carboxymethylcellulose 
               
               
                 Titanium (IV) oxide 
                 Titanium (IV) oxide 
                 0.50 
               
               
                 Sodium laurylsulphate (SLS) 
                 Sodium laurylsulphate (SLS) 
                 1.50 
               
               
                 Aroma (PF1, PF2, PF3 or PF4) 
                 Flavour 
                 1.00 
               
            
           
           
               
               
            
               
                 Concentrated Herba Santa extract ( E. californicum ) 
                 0.40 
               
               
                 as per Ex. 7 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XIV 
               
             
            
               
                   
               
               
                 Anti-plaque toothpaste (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                   
                 Ingredient 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Carrageenan 
                 0.90 
                 0.90 
               
               
                   
                 Glycerol 
                 15.00 
                 15.00 
               
               
                   
                 Sorbitol 70%, in water 
                 25.00 
                 25.00 
               
               
                   
                 PEG 1000 
                 3.00 
                 3.00 
               
               
                   
                 Na fluoride 
                 0.24 
                 0.24 
               
               
                   
                 Tetrapotassium diphosphate 
                 4.50 
                 4.50 
               
               
                   
                 Tetrasodium diphosphate 
                 1.50 
                 1.50 
               
               
                   
                 Na saccharinate 
                 0.40 
                 0.40 
               
               
                   
                 Precipit. silica gel 
                 20.00 
                 20.00 
               
               
                   
                 Titanium dioxide 
                 1.00 
                 1.00 
               
               
                   
                 Triclosan 
                 0.30 
                 0.30 
               
               
                   
                 PHB methyl ester 
                 0.10 
                 0.10 
               
               
                   
                 Spearmint flavour (containing 
                 1.00 
                 1.20 
               
               
                   
                 60 wt. % L-carvone and 25 wt. % 
               
               
                   
                 L-menthol) 
               
               
                   
                 Concentrated Herba Santa 
                 0.30 
                 — 
               
               
                   
                 extract ( E. californicum ) as 
               
               
                   
                 per Ex. 7 (10% in ethanol) 
               
               
                   
                 Herba Santa extract 
                 — 
                 0.50 
               
               
                   
                 ( E. californicum ) as 
               
               
                   
                 per Ex. 1 (10% in ethanol) 
               
               
                   
                 Sodium dodecylsulphate 
                 1.30 
                 1.30 
               
            
           
           
               
               
               
               
            
               
                   
                 Demin. water 
                 Ad 100 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XV 
               
             
            
               
                   
               
               
                 Tooth cream for pain-sensitive teeth (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                   
                 Ingredient 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Na carboxymethylcellulose 
                 0.70 
                 0.70 
               
               
                   
                 Xanthan gum 
                 0.50 
                 0.50 
               
               
                   
                 Glycerol 
                 15.00 
                 15.00 
               
               
                   
                 Sorbitol 70%, in water 
                 12.00 
                 12.00 
               
               
                   
                 Potassium nitrate 
                 5.00 
                 5.00 
               
               
                   
                 Sodium monofluorophosphate 
                 0.80 
                 0.80 
               
               
                   
                 PHB methyl ester 
                 0.15 
                 0.15 
               
               
                   
                 PHB propyl ester 
                 0.05 
                 0.05 
               
               
                   
                 Na saccharinate 
                 0.20 
                 0.20 
               
               
                   
                 Flavour (PF1, PF2, PF3 or PF4) 
                 1.00 
                 1.00 
               
               
                   
                 Herba Santa extract ( E. angustifolium ) 
                 0.50 
                 — 
               
               
                   
                 as per Ex. 1 (10% in ethanol) 
               
               
                   
                 Herba Santa extract ( E. californicum ) 
                 — 
                 0.25 
               
               
                   
                 as per Ex. 5 (10% in ethanol) 
               
               
                   
                 Ca carbonate 
                 35.00 
                 35.00 
               
               
                   
                 Silicon dioxide 
                 1.00 
                 1.00 
               
               
                   
                 Sodium dodecylsulphate (SDS) 
                 1.50 
                 1.50 
               
            
           
           
               
               
               
               
            
               
                   
                 Demin. water 
                 Ad 100 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XVI 
               
             
            
               
                   
               
               
                 Gelatine capsules for bad breath for direct 
               
               
                 consumption (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredients 
                 A 
                 B 
                 C 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Gelatine casing 
                 Glycerine 
                 2.014 
                 2.014 
                 2.014 
               
               
                   
                 Gelatine 240 Bloom 
                 7.91 
                 7.91 
                 7.91 
               
               
                   
                 Sucralose 
                 0.065 
                 0.065 
                 0.065 
               
               
                   
                 Allura Red 
                 0.006 
                 0.006 
                 0.006 
               
               
                   
                 Brilliant Blue 
                 0.005 
                 0.005 
                 0.005 
               
               
                 Core filling 
                 Plant oil triglycerides 
                 82.00 
                 74.00 
                 60.00 
               
               
                   
                 Flavour B 
                 7.9 
                 15.50 
                 29.5 
               
               
                   
                 Herba Santa extract 
                 0.10 
                 0.50 
                 — 
               
               
                   
                 ( E. angustifolium ) 
               
               
                   
                 as per Ex. 1 
               
               
                   
                 (10% in ethanol) 
               
               
                   
                 Herba Santa extract 
                 0.10 
                 — 
                 0.50 
               
               
                   
                 ( E. californicum ) as 
               
               
                   
                 per Ex. 5 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     Flavour B had the following composition (data in weight %): 0.1% neotame (powder), 0.05% aspartame, 29.3% peppermint oil (Avensis), 29.3% peppermint oil (Piperita; Willamette), 2.97% sucralose, 2.28% triacetin, 5.4% diethyl tartrate, 12.1% peppermint oil (Yakima), 0.7% ethanol, 3.36% 2-hydroxyethyl menthyl carbonate, 3.0% 2-hydroxypropyl menthyl carbonate, 0.27% vanillin, 5.5% D-limonene, 5.67% L-menthyl acetate. 
     The gelatine capsule, which is suitable for direct consumption, has a diameter of 5 mm; the weight ratio between core and casing material is about 90:10. The capsules open in the mouth in less than 10 secs, and dissolve completely within 50 secs. 
     
       
         
           
               
             
               
                 TABLE XVII 
               
             
            
               
                   
               
               
                 Syndet - soap-free cleansing bar (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredient 
                 INCI 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Zetesap 813 A 
                 Disodium lauryl sulpho- 
                 92.0 
                 91.9 
               
               
                   
                 succinate, sodium lauryl 
               
               
                   
                 sulphate, corn starch, 
               
               
                   
                 cetearyl alcohol, paraffin, 
               
               
                   
                 titanium dioxide 
               
               
                 Amphotensid GB 2009 
                 Disodium cocoamphodiacetate 
                 6.0 
                 6.0 
               
               
                 Allantoin 
                 Allantoin 
                 1.0 
                 1.0 
               
               
                 Perfume oil P2, 
                 Fragrance 
                 1.0 
                 — 
               
               
                 P4, P6 or P7 
               
               
                 Perfume oil P1, 
                 Fragrance 
                 — 
                 1.0 
               
               
                 P3 or P5 
               
            
           
           
               
               
               
            
               
                 Herba Santa extract ( E. angustifolium ) 
                 0.5 
                 — 
               
               
                 as per Example 1 (10% in EtoH) 
               
               
                 Concentrated Herba Santa extract ( E. angustifolium ) 
                 — 
                 0.1 
               
               
                 as per Example 4 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XVIII 
               
             
            
               
                   
               
               
                 Soap bar (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredient 
                 INCI 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Demin. water 
                 Water 
                 2.5 
                 2.5 
               
               
                 Soap base mix 
                 Sodium tallowates/ 
                 95.5 
                 95.8 
               
               
                   
                 palmitates 
               
               
                 Titanium dioxide 
                 Titanium dioxide 
                 1.0 
                 1.0 
               
               
                 Perfume oil P2, 
                 Fragrance 
                 0.8 
                 — 
               
               
                 P4, P6 or P7 
               
               
                 Perfume oil P1, 
                 Fragrance 
                 — 
                 0.5 
               
               
                 P3 or P5 
               
            
           
           
               
               
               
            
               
                 Concentrated Herba Santa extract ( E. angustifolium ) 
                 0.2 
                 — 
               
               
                 as per Example 4 (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract ( E. californicum ) 
                 — 
                 0.2 
               
               
                 as per Example 7 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XIX 
               
             
            
               
                   
               
               
                 Antimicrobial soap bar (amounts in % b.w.) 
               
            
           
           
               
               
               
            
               
                 Ingredients 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Sodium soap from tallow 
                 60.0 
                 60.0 
               
               
                 Sodium soap from palm oil 
                 27.0 
                 27.0 
               
               
                 Glycerol 
                 2.0 
                 2.0 
               
               
                 Sodium chloride 
                 0.5 
                 0.5 
               
               
                 1-hydroxyethane-1,1-diphosphoric 
                 0.3 
                 0.3 
               
               
                 acid, tetrasodium salt 
               
               
                 Alpha-tocopherol 
                 0.1 
                 0.1 
               
               
                 Pigment yellow 1 
                 0.02 
                 0.02 
               
            
           
           
               
               
            
               
                 Water 
                 Ad 100 
               
            
           
           
               
               
               
            
               
                 Perfume oil P2, P4, P6 or P7 
                 3.0 
                 — 
               
               
                 Perfume oil P1, P3 or P5 
                 — 
                 3.0 
               
               
                 Herba Santa extract (E.) 
                 0.5 
               
               
                 as per Example 1 (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract ( E. angustifolium ) 
                 — 
                 0.2 
               
               
                 as per Example 7 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XX 
               
             
            
               
                   
               
               
                 Liquid soap (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredient 
                 INCI 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Tagat O 2 
                 PEG-20 Glyceryl oleate 
                 2.5 
                 2.5 
               
               
                 Coconut fatty acid 
                 Cocamide DEA 
                 5.0 
                 5.0 
               
               
                 diethanolamide 
               
               
                 Abil B 8842 
                 Cyclomethicone 
                 0.5 
                 0.5 
               
               
                 Sodium laurylether 
                 Sodium laureth sulphate 
                 35.0 
                 35.0 
               
               
                 sulphate, 28% 
               
               
                 Tego-betaine L7 
                 Cocamidopropyl betaine 
                 5.0 
                 5.0 
               
               
                 Soap, 25% 
                 Coconut acid, potassium 
                 20.0 
                 20.0 
               
               
                   
                 salt, potassium oleate 
               
            
           
           
               
               
               
            
               
                 Water 
                 Water 
                 Ad 100 
               
            
           
           
               
               
               
               
            
               
                 Preservative 
                 DMDM hydantoin 
                   
                   
               
               
                 Perfume oil P2, 
                 Fragrance 
                 0.4 
                 — 
               
               
                 P4, P6 or P7 
               
               
                 Perfume oil P1, 
                 Fragrance 
                 — 
                 0.4 
               
               
                 P3 or P5 
               
            
           
           
               
               
               
            
               
                 Concentrated Herba Santa extract ( E. angustifolium ) 
                 0.4 
                 0.3 
               
               
                 as per Ex. 4 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXI 
               
             
            
               
                   
               
               
                 Liquid soap (Syndet) (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredients 
                 INCI 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Elfan OS 46 
                 Sodium olefin C14-C16 
                 35.5 
                 35.5 
               
               
                   
                 sulphonate 
               
               
                 Armoteric LB 
                 Lauryl betaine 
                 8.0 
                 8.0 
               
               
                 Elfan SG 
                   
                 10.0 
                 10.0 
               
               
                 Elfacos GT 282 L 
                 Talloweth-60 myristyl glycol 
                 3.0 
                 3.0 
               
               
                 PCL-Liquid 100 
                 cetearyl ethylhexanoate 
                 4.0 
                 4.0 
               
            
           
           
               
               
               
            
               
                 Water 
                 water 
                 Ad 100 
               
            
           
           
               
               
               
               
            
               
                 Perfume oil P2, 
                 Fragrance 
                 0.4 
                 — 
               
               
                 P4, P6 or P7 
               
               
                 Perfume oil P1, 
                 Fragrance 
                 — 
                 0.4 
               
               
                 P3 or P5 
               
            
           
           
               
               
               
            
               
                 Herba Santa extract ( E. angustifolium ) 
                 0.5 
                   
               
               
                 as per Ex. 1 (10% in ethanol) 
               
               
                 Herba Santa extract ( E. californicum ) 
                   
                 0.3 
               
               
                 as per Ex. 5 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXII 
               
             
            
               
                   
               
               
                 Shampoo 
               
            
           
           
               
               
               
               
            
               
                   
                 Ingredients 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Sodium lauryl ether sulphate 
                 12 
                 12 
               
               
                   
                 (e.g. Texapon NSO) 
               
               
                   
                 Cocamidopropylbetaine (e.g. Dehyton K) 
                 2 
                 2 
               
               
                   
                 Sodium chloride 
                 1.4 
                 1.4 
               
               
                   
                 Citric acid 
                 1.3 
                 1.3 
               
               
                   
                 Phenoxyethanol, methyl, ethyl, 
                 0.5 
                 0.5 
               
               
                   
                 butyl and propylparaben 
               
               
                   
                 Perfume oil P2, P4, P6 or P7 
                 0.3 
                 — 
               
               
                   
                 Perfume oil P1, P3 or P5 
                 — 
                 0.3 
               
               
                   
                 Herba Santa extract ( E. californicum ) 
                 0.25 
                 — 
               
               
                   
                 as per Ex. 5 (10% in ethanol) 
               
               
                   
                 Herba Santa extract ( E. californicum ) 
                   
                 0.15 
               
               
                   
                 as per Ex. 7 (10% in ethanol) 
               
            
           
           
               
               
               
               
            
               
                   
                 Water 
                 Ad 100 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXIII 
               
             
            
               
                   
               
               
                 2 in 1 - Shampoo (all amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredients 
                 INCI 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Demineralized water 
                 Water 
                 Ad 100 
               
            
           
           
               
               
               
               
            
               
                 Plantacare PS 10 
                 Sodium laureth sulphate, 
                 20.0 
                 20.0 
               
               
                   
                 lauryl glucoside 
               
               
                 Euperlan PK 771 
                 Glycol distearate, 
                 6.0 
                 6.0 
               
               
                   
                 sodium lauryl sul- 
               
               
                   
                 phate, cocamide MEA, 
               
               
                   
                 laureth-10 
               
               
                 Dragocid liquid 
                 Phenoxyethanol, methyl- 
                 0.5 
                 0.5 
               
               
                   
                 paraben, ethylparaben, 
               
               
                   
                 butylparaben, 
               
               
                   
                 propylparaben, 
               
               
                   
                 isobutylparaben 
               
               
                 Sodium chloride 
                 Sodium chloride 
                 1.4 
                 1.4 
               
               
                 Citric acid monohydrate 
                 Citric acid 
                 0.1 
                 0.1 
               
               
                 (crystalline) 
               
               
                 Perfume oil P2, 
                 Fragrance 
                 0.5 
                 — 
               
               
                 P4, P6 or P7 
               
               
                 Perfume oil P1, 
                 Fragrance 
                 — 
                 0.5 
               
               
                 P3 or P5 
               
            
           
           
               
               
               
            
               
                 Concentrated Herba Santa extract ( E. angustifolium ) 
                 0.15 
                 — 
               
               
                 as per Ex. 4 (10% in ethanol) 
               
               
                 Herba Santa extract ( E. californicum ) 
                 — 
                 0.15 
               
               
                 as per Ex. 8 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXIV 
               
             
            
               
                   
               
               
                 Anti-dandruff shampoo (all amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredients 
                 INCI 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Climbazole 
                 Climbazole 
                 0.50 
                 0.50 
               
               
                 Phenoxyethanol, 
                 Phenoxyethanol, methylparaben, 
                 0.70 
                 0.70 
               
               
                 methylparaben, 
                 ethylparaben, butylparaben, 
               
               
                 Ethylparaben, 
                 propylparaben, isobutylparaben 
               
               
                 Butylparaben, 
               
               
                 Propylparaben, 
               
               
                 Isobutylparaben 
               
            
           
           
               
               
               
            
               
                 Herba Santa extract ( E. angustifolium ) 
                 0.60 
                 — 
               
               
                 as per Ex. 1 (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract ( E. angustifolium ) 
                 — 
                 0.40 
               
               
                 as per Ex. 4 (10% in ethanol) 
               
            
           
           
               
               
               
               
            
               
                 Sodium laureth sulphate 
                 Sodium laureth sulphate 
                 37.00 
                 37.00 
               
               
                 Cocamidopropyl betaine 
                 Cocamidopropyl betaine 
                 8.00 
                 8.00 
               
               
                 PEG-6 
                 PEG-6 caprylic/capric glycerides 
                 2.50 
                 2.50 
               
               
                 Laureth -2 
                 Laureth-2 
                 2.00 
                 2.00 
               
               
                 Thyme extract 
                 Water (aqua), glycerol, 
                 0.50 
                 0.50 
               
               
                   
                   Thymus vulgaris  (thyme), 
               
               
                   
                 flower/leaf extract 
               
               
                 Rosemary extract 
                 
                   Rosmarinus officinalis 
                 
                 0.50 
                 0.50 
               
               
                   
                 (rosemary) leaf water, 
               
               
                   
                 water (aqua), butylene 
               
               
                   
                 glycol, pentylene glycol 
               
               
                 Bisabolol 
                 Bisabolol 
                 0.10 
                 0.10 
               
               
                 Panthenol 
                 Panthenol 
                 0.50 
                 0.50 
               
               
                 Perfume oil P2, 
                 Fragrance 
                 0.50 
                 — 
               
               
                 P4, P6 or P7 
               
               
                 Perfume oil P1, 
                 Fragrance 
                 — 
                 0.50 
               
               
                 P3 or P5 
               
               
                 Water 
                 Water (aqua) 
                 46.30 
                 46.30 
               
               
                 Polyquaternium-10 
                 Polyquaternium-10 
                 0.40 
                 0.40 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXV 
               
             
            
               
                   
               
               
                 Shower gel (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredients 
                 INCI 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Demin. water 
                 Water 
                 Ad 100 
               
            
           
           
               
               
               
               
            
               
                 Plantacare PS 10 
                 Sodium laureth sulphate, 
                 20.0 
                 20.0 
               
               
                   
                 lauryl glucoside 
               
               
                 Dragocid Liquid 
                 Phenoxyethanol, 
                 0.5 
                 0.5 
               
               
                   
                 methylparaben, 
               
               
                   
                 ethylparaben, 
               
               
                   
                 butylparaben, 
               
               
                   
                 propylparaben, 
               
               
                   
                 isobutylparaben 
               
               
                 Sodium chloride 
                 Sodium chloride 
                 1.4 
                 1.4 
               
               
                 Citric acid monohydrate 
                 Citric acid 
                 1.3 
                 1.3 
               
               
                 (crystalline) 
               
               
                 Perfume oil P2, 
                 Fragrance 
                 0.6 
                 — 
               
               
                 P4, P6 or P7 
               
               
                 Perfume oil P1, 
                 Fragrance 
                 — 
                 0.6 
               
               
                 P3 or P5 
               
            
           
           
               
               
               
            
               
                 Herba Santa extract ( E. angustifolium ) 
                 0.1 
                   
               
               
                 as per Example 1 (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract ( E. angustifolium ) 
                   
                 0.05 
               
               
                 as per Example 4 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXVI 
               
             
            
               
                   
               
               
                 Shaving foam (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                   
                 Ingredients 
                 A 
                 B 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Demin. water 
                 77.2 
                 77.22 
               
               
                   
                 Triethanolamine 
                 4.0 
                 4.0 
               
               
                   
                 Edenor L2 SM (stearic acid, 
                 5.3 
                 5.3 
               
               
                   
                 palmitic acid) (Cognis) 
               
               
                   
                 Laureth-23 
                 3.0 
                 3.0 
               
               
                   
                 Stearyl alcohol 
                 0.5 
                 0.5 
               
               
                   
                 Euxyl ® K220 (methylisothiazolinone, 
                 0.8 
                 0.8 
               
               
                   
                 ethylhexylglycerol) 
               
               
                   
                 Sodium lauryl sulphate 
                 3.0 
                 3.0 
               
               
                   
                 Extrapone seaweed/alga (water, 
                 1.0 
                 1.0 
               
               
                   
                 propylene glycol, potassium iodide, 
               
               
                   
                   Fucus Vesiculosus  Extract) 
               
               
                   
                 Dragosantol (bisabolol, farnesol) 
                 0.1 
                 0.1 
               
               
                   
                 Perfume oil P2, P4, P6 or P7 
                 1.0 
                 — 
               
               
                   
                 Perfume oil P1, P3 or P5 
                 — 
                 1 
               
               
                   
                 Herba Santa extract ( E. californicum ) 
                 0.1 
                 — 
               
               
                   
                 as per Example 5 (10% in EtOH) 
               
               
                   
                 Concentrated Herba Santa extract as 
                 — 
                 0.08 
               
               
                   
                 per Example 8 (10% in ethanol) 
               
               
                   
                 Propane, butane 4.2 bar 
                 4.0 
                 4.0 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXVII 
               
             
            
               
                   
               
               
                 Aftershave (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredients 
                 INCI 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 SymSol ® PF-3 
                 Water (aqua), pentylene 
                 3.00 
                 3.00 
               
               
                   
                 glycol, sodium lauryl 
               
               
                   
                 sulphoacetate, sodium 
               
               
                   
                 oleoyl sarcosinate, so- 
               
               
                   
                 dium chloride, disodium 
               
               
                   
                 sulphoacetate, sodium 
               
               
                   
                 oleate, sodium sulphate 
               
               
                 SymSitive ® 1609 
                 Pentylene glycol, 
                 1.00 
                 1.00 
               
               
                   
                 4-t-butylcyclo-hexanol 
               
               
                 Frescolat ® ML 
                 Menthyl lactate 
                 0.30 
                 0.30 
               
               
                 Glycerol 99.5 P. 
                 Glycerol 
                 5.00 
                 5.00 
               
            
           
           
               
               
               
            
               
                 Water 
                 Water (aqua) 
                 Ad 100 
               
            
           
           
               
               
               
               
            
               
                 Extrapone ® Glacier 
                 Glycerol, Water (aqua) 
                 1.00 
                 1.00 
               
               
                 Water GW 
               
               
                 SymCalmin ® 
                 Butylene glycol, pentylene 
                 0.50 
                 0.50 
               
               
                   
                 glycol, hydroxyphenyl 
               
               
                   
                 propamidobenzoic acid 
               
               
                 Dragosine ® 
                 Carnosine 
                 0.10 
                 0.10 
               
               
                 Hydrolite ® 5 
                 Pentylene glycol 
                 5.00 
                 5.00 
               
               
                 Ethanol 96% 
                 Alcohol denat. 
                 5.00 
                 5.00 
               
               
                 Colour pigment 
                 Colour pigment 
                 0.05 
                 0.05 
               
               
                 Perfume oil P2, P4, 
                 Perfume 
                 0.15 
                 — 
               
               
                 P6 or P7 
               
               
                 Perfume oil P1, P3 
                 Perfume 
                 — 
                 0.15 
               
               
                 or P5 
               
            
           
           
               
               
               
            
               
                 Herba Santa extract ( E. angustifolium ) 
                 0.15 
                 — 
               
               
                 as per Example 1 (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract ( E. angustifolium ) 
                 — 
                 0.08 
               
               
                 as per Example 4 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXVIII 
               
             
            
               
                   
               
               
                 Deodorant formulation (Roll-on gel) (amounts in % b.w.) 
               
            
           
           
               
               
               
            
               
                 Ingredients 
                 A 
                 B 
               
               
                   
               
               
                 1,3-Butylene glycol 
                 2.00 
                 2.00 
               
               
                 PEG-40-hydrogen. castor oil 
                 2.00 
                 2.00 
               
               
                 Hydroxyethylcellulose 
                 0.50 
                 0.50 
               
               
                 Preservative (phenoxyethanol) 
                 0.30 
                 0.30 
               
               
                 Perfume oil P2, P4, P6 or P7 
                 0.30 
                 — 
               
               
                 Perfume oil P1, P3 or P5 
                 — 
                 0.30 
               
               
                 Herba Santa extract ( E. angustifolium ) 
                 0.30 
                 — 
               
               
                 as per Example 1 (10% in EtoH) 
               
               
                 Concentrated Herba Santa extract ( E. angustifolium ) 
                 — 
                 0.10 
               
               
                 as per Example 4 (10% in ethanol) 
               
            
           
           
               
               
            
               
                 Water 
                 Ad 100 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXIX 
               
             
            
               
                   
               
               
                 Deodorant stick (amounts in % b.w.) 
               
            
           
           
               
               
               
            
               
                   
                 Weight 
                 Weight 
               
               
                 Ingredients 
                 % 
                 % 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Sodium stearate 
                 8.00 
                 8.00 
               
               
                 PPG-3 myristyl ether 
                 70.00 
                 70.00 
               
               
                 1,2-propylene glycol 
                 10.00 
                 10.00 
               
               
                 1,1-dimethyl-3-phenylpropanol 
                 0.20 
                 0.25 
               
               
                 2-butyloctanoic acid 
                 0.20 
                 0.20 
               
               
                 Perfume oil P2, P4, P6 or P7 
                 0.60 
                 — 
               
               
                 Perfume oil P1, P3 or P5 
                 — 
                 0.60 
               
               
                 Herba Santa extract ( E. angustifolium ) 
                 0.30 
                 — 
               
               
                 as per Example 1 (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract ( E. californicum ) 
                 — 
                 0.20 
               
               
                 as per Example 7 (10% in ethanol) 
               
            
           
           
               
               
            
               
                 Water 
                 Ad 100 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXX 
               
             
            
               
                   
               
               
                 Antiperspirants (amounts in % b.w.) 
               
            
           
           
               
               
               
            
               
                 Ingredients 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Reach AZP-908 SUF 
                 24.00 
                 22.00 
               
            
           
           
               
               
            
               
                 Cyclomethicone (pentamer) 
                 Ad 100 
               
            
           
           
               
               
               
            
               
                 Polydecene (Silkflo 364 NF) 
                 17.50 
                 20.00 
               
               
                 Neo Heliopan OS (ethylhexyl salicylate) 
                 2.50 
                 1.00 
               
               
                 L-menthyl lactate (Frescolate ML) 
                 0.25 
                 — 
               
               
                 Polyethylene 
                 3.00 
                 3.00 
               
               
                 Hydrogen. castor oil 
                 2.00 
                 2.00 
               
               
                 Promyristyl PM-3 
                 7.00 
                 7.00 
               
               
                 PEG-8 distearate 
                 3.00 
                 3.00 
               
               
                 Silicon dioxide (Cab-O-Sil M-5) 
                 1.00 
                 1.00 
               
               
                 Stearyl alcohol 
                 15.00 
                 10.00 
               
               
                 Octyldodecanol 
                 — 
                 8.00 
               
               
                 Perfume oil P2, P4, P6 or P7 
                 0.80 
                 — 
               
               
                 Perfume oil P1, P3 or P5 
                 — 
                 0.80 
               
               
                 Herba Santa extract ( E. angustifolium ) 
                 0.30 
                 — 
               
               
                 as per Example 1 (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract ( E. angustifolium ) 
                 — 
                 0.30 
               
               
                 as per Example 4 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXXI 
               
             
            
               
                   
               
               
                 O/W lotion (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredients 
                 INCI 
                 A 
                 B 
               
               
                   
               
               
                 Paraffin oil 
                 Paraffin oil 
                 5.00 
                 5.00 
               
               
                 Isopropyl palmitate 
                 Isopropyl palmitate 
                 5.00 
                 5.00 
               
               
                 Cetyl alcohol 
                 Cetyl alcohol 
                 2.00 
                 2.00 
               
               
                 Beeswax 
                 Beeswax 
                 2.00 
                 2.00 
               
               
                 Ceteareth-20 
                 Ceteareth-20 
                 2.00 
                 2.00 
               
               
                 PEG-20 glyceryl 
                 PEG-20 glyceryl 
                 1.50 
                 1.50 
               
               
                 stearate 
                 stearate 
               
               
                 Glycerol 
                 Glycerol 
                 3.00 
                 3.00 
               
               
                 Perfume oil P2, 
                 Perfume 
                 0.30 
                 — 
               
               
                 P4, P6 or P7 
               
               
                 Perfume oil P1, 
                 Perfume 
                 — 
                 0.30 
               
               
                 P3 or P5 
               
            
           
           
               
               
               
            
               
                 Herba Santa extract ( E. californicum ) 
                 0.25 
                 — 
               
               
                 as per Example 5 (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract ( E. californicum ) 
                 — 
                 0.10 
               
               
                 as per Example 7 (10% in ethanol) 
               
            
           
           
               
               
               
               
            
               
                 Methylparaben 
                 Methylparabens 
                 0.30 
                 0.30 
               
            
           
           
               
               
               
            
               
                 Water 
                 Water 
                 Ad 100 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXXII 
               
             
            
               
                   
               
               
                 Body lotion (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredients 
                 INCI 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Cetearyl alcohol 
                 Cetearyl alcohol 
                 2.00 
                 2.00 
               
               
                 Ethylhexyl isononanoate 
                 Ethylhexyl isononanoate 
                 5.00 
                 5.00 
               
               
                 Cetearyl ethylhexanoate, 
                 Cetearyl ethylhexanoate, 
                 3.00 
                 3.00 
               
               
                 isopropyl myristate 
                 isopropyl myristate 
               
               
                 Glyceryl oleate citrate, 
                 Glyceryl oleate citrate, 
                 4.00 
                 4.00 
               
               
                 caprylic/capric triglyceride 
                 caprylic/capric triglyceride 
               
               
                 Water 
                 Water (aqua) 
                 79.50 
                 79.50 
               
               
                 Carbomer 
                 Carbomer 
                 0.30 
                 0.30 
               
               
                 Sodium benzoate 
                 Sodium benzoate 
                 0.10 
                 0.10 
               
               
                 Propylene glycol 
                 Propylene glycol 
                 5.00 
                 5.00 
               
               
                 Triethylene glycol, 
                 Triethylene glycol, imida- 
                 0.30 
                 0.30 
               
               
                 imidazolidinylurea, 
                 zolidinylurea, methylpara- 
               
               
                 methylparaben, 
                 ben, propylparaben, dehy- 
               
               
                 propylparaben, dehy- 
                 droacetic acid 
               
               
                 droacetic acid 
               
               
                 Sodium hydroxide 
                 Sodium hydroxide 30% 
                 0.30 
                 0.30 
               
               
                 Soln. (30%) 
                 solution 
               
               
                 Perfume oil P2, P4, 
                 Perfume 
                 0.30 
                 — 
               
               
                 P6 or P7 
               
               
                 Perfume oil P1, P3 or P5 
                 Perfume 
                 — 
                 0.30 
               
            
           
           
               
               
               
            
               
                 Herba Santa extract ( E. angustifolium ) as per 
                 0.10 
                 — 
               
               
                 Example 1 (10% in ethanol) 
               
               
                 Herba Santa extract ( E. californicum ) as per 
                 — 
                 0.10 
               
               
                 Example 5 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXXIII 
               
             
            
               
                   
               
               
                 Hand and body cream (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredients 
                 INCI 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Dracorin ® GOC 
                 Glyceryl oleate citrate, 
                 2.00 
                 2.00 
               
               
                   
                 caprylic/capric triglycerides 
               
               
                 PCL-Solid 
                 Stearyl heptanoate, stearyl 
                 2.50 
                 2.50 
               
               
                   
                 caprylate 
               
               
                 Lanette ® O 
                 Cetearyl alcohol 
                 1.50 
                 1.50 
               
               
                 Cutina ® GMS-V 
                 Glyceryl stearate 
                 1.00 
                 1.00 
               
               
                 Dragoxat ® 89 
                 Ethylhexyl isononanoate 
                 3.00 
                 3.00 
               
               
                 PCL-Liquid 100 
                 Cetearyl ethylhexanoate 
                 7.00 
                 7.00 
               
               
                 Isodragol ® 
                 Triisononanoin 
                 4.00 
                 4.00 
               
               
                 Xiameter ® PMX-0345 
                 Cyclopentasiloxane (and) 
                 0.50 
                 0.50 
               
               
                 Cyclosiloxane 
                 cyclohexasiloxane 
               
            
           
           
               
               
               
            
               
                 Water 
                 Water (aqua) 
                 Ad 100 
               
            
           
           
               
               
               
               
            
               
                 Carbopol ® Ultrez 21 
                 Acrylates/C10-30 alkyl acry- 
                 0.20 
                 0.20 
               
               
                   
                 late crosspolymer 
               
               
                 Keltrol ® CG-RD 
                 Xanthan gum 
                 0.10 
                 0.10 
               
               
                 Glycerol 85 P. 
                 Glycerol 
                 3.00 
                 3.00 
               
               
                 DragoBetaGlucan 
                 Water (aqua), butylene 
                 1.50 
                 1.50 
               
               
                   
                 glycol, glycerol,  Avena sa - 
               
               
                   
                   tiva  (oat) kernel extract 
               
               
                 Potassium sorbate 
                 Potassium sorbate 
                 0.10 
                 0.10 
               
               
                 euxyl ® K300 
                 Methyl, butyl, ethyl, propyl, 
                 0.80 
                 0.80 
               
               
                   
                 isobutylparaben, 
               
               
                   
                 phenoxyethanol. 
               
               
                 Sodium hydroxide 
                 Sodium hydroxide 
                 0.50 
                 0.50 
               
               
                 10% solution 
               
               
                 Perfume oil P2, 
                 Perfume 
                 0.20 
                 — 
               
               
                 P4, P6 or P7 
               
               
                 Perfume oil P1, 
                 Perfume 
                 — 
                 0.20 
               
               
                 P3 or P5 
               
            
           
           
               
               
               
            
               
                 Herba Santa extract ( E. angustifolium ) as per 
                 0.20 
                 — 
               
               
                 Example 1 (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract ( E. angustifolium ) 
                 — 
                 0.15 
               
               
                 as per Example 4 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXXIV 
               
             
            
               
                   
               
               
                 Face cream (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                   
                   
                 Weight 
                 Weight 
               
               
                 Ingredients 
                 INCI 
                 % 
                 % 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Emulsiphos ® 
                 Potassium cetyl 
                 1.50 
                 1.50 
               
               
                   
                 phosphate, hydrogenated 
               
               
                   
                 palm glycerides 
               
               
                 Cutina ® GMS-V 
                 Glyceryl stearate 
                 1.70 
                 1.70 
               
               
                 Lanette ® O 
                 Cetearyl alcohol 
                 3.00 
                 3.00 
               
               
                 Tegosoft ® MM 
                 Myristyl myristate 
                 1.00 
                 1.00 
               
               
                 PCL-Liquid 100 
                 Cetearyl ethylhexanoate 
                 1.00 
                 1.00 
               
               
                 Isodragol ® 
                 Triisononanoin 
                 3.00 
                 3.00 
               
               
                 Dragoxat ® 89 
                 Ethylhexyl isononanoate 
                 4.00 
                 4.00 
               
               
                 Avocado oil 
                 
                   Persea gratissima 
                 
                 3.00 
                 3.00 
               
               
                   
                 (avocado) oil 
               
               
                 Abil ® 350 
                 Dimethicone 
                 0.50 
                 0.50 
               
               
                 Covi-ox ® T-70 
                 Tocopherol 
                 0.10 
                 0.10 
               
               
                 Edeta ® BD 
                 Disodium EDTA 
                 0.10 
                 0.10 
               
               
                 Carbopol ® 
                 Acrylates/C10-30 alkyl 
                 0.30 
                 0.30 
               
               
                 Ultrez 21 
                 acrylate crosspolymer 
               
               
                 Keltrol ® CG-RD 
                 Xanthan gum 
                 0.15 
                 0.15 
               
            
           
           
               
               
               
            
               
                 Water 
                 Water (aqua) 
                 Ad 100 
               
            
           
           
               
               
               
               
            
               
                 Glycerol 99.5 P. 
                 Glycerol 
                 4.00 
                 4.00 
               
               
                 Propylene glycol- 
                 Propylene glycol 
                 3.00 
                 3.00 
               
               
                 1,2 99 P GC 
               
               
                 Euxyl ® K712 
                 Sodium benzoate, 
                 0.80 
                 0.80 
               
               
                   
                 potassium sorbate 
               
               
                 SymMatrix ® 
                 Maltodextrin, 
                 0.50 
                 0.50 
               
               
                   
                 
                   Rubus fruticosus 
                 
               
               
                   
                 (blackberry) 
               
               
                   
                 leaf extract 
               
               
                 Sodium hydroxide 
                 Sodium hydroxide 
                 0.50 
                 0.50 
               
               
                 10% solution 
               
               
                 Perfume oil P2, 
                 Perfume 
                 0.30 
                 — 
               
               
                 P4, P6 or P7 
               
               
                 Perfume oil P1, 
                 Perfume 
                 — 
                 0.30 
               
               
                 P3 or P5 
               
            
           
           
               
               
               
            
               
                 Concentrated Herba Santa extract ( E. angustifolium ) 
                 0.10 
                 — 
               
               
                 as per Example 4 (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract ( E. californicum ) 
                 — 
                 0.10 
               
               
                 as per Example 8 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXXV 
               
             
            
               
                   
               
               
                 Anti-wrinkle cream (amounts in % b.w.) 
               
            
           
           
               
               
               
            
               
                 Ingredients 
                 A 
                 B 
               
               
                   
               
               
                 Glyceryl stearate citrate 
                 1.00 
                 1.00 
               
               
                 Glyceryl laurate 
                 1.00 
                 1.00 
               
               
                 Cetearyl alcohol, 
                 2.00 
                 2.00 
               
               
                 Myristyl myristate 
                 1.00 
                 1.00 
               
               
                 Cetearyl ethylhexanoate 
                 4.00 
                 4.00 
               
               
                 Mineral oil 
                 4.00 
                 4.00 
               
               
                 Cyclopentasiloxane, cyclohexasiloxane 
                 0.50 
                 0.50 
               
               
                 Acrylate/C10-30 alkylarylate crosspolymer 
                 0.20 
                 0.20 
               
               
                 Preservative (phenoxyethanol) 
                 1.00 
                 1.00 
               
            
           
           
               
               
            
               
                 Water 
                 Ad 100 
               
            
           
           
               
               
               
            
               
                 Xanthan gum 
                 0.10 
                 0.10 
               
               
                 1,2-hexanediol 
                 2.00 
                 2.00 
               
               
                 Sodium hydroxide 10% soln. 
                 0.10 
                 0.10 
               
               
                   Narcissus Tazetta  extract 
                 1.00 
                 1.00 
               
               
                 Perfume oil P2, P4, P6 or P7 
                 0.30 
                 — 
               
               
                 Perfume oil P1, P3 or P5 
                 — 
                 0.30 
               
               
                 Concentrated Herba Santa extract ( E. angustifolium ) 
                 0.10 
                 — 
               
               
                 as per Example 4 (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract ( E. californicum ) 
                 — 
                 0.10 
               
               
                 as per Example 8 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXXVI 
               
             
            
               
                   
               
               
                 Washing and cleansing gel (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredient 
                 INCI 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Water 
                 Water (aqua) 
                 Ad 100 
               
            
           
           
               
               
               
               
            
               
                 Pionier ® NP 37 G 
                 Sodium carbomer 
                 1.50 
                 1.50 
               
               
                 SymSol ® PF-3 
                 Water (aqua), pentylene glycol, 
                 5.00 
                 5.00 
               
               
                   
                 sodium lauryl sulphoacetate, 
               
               
                   
                 sodium oleoyl sarcosinate, 
               
               
                   
                 sodium chloride, disodium 
               
               
                   
                 sulphoacetate, sodium oleate, 
               
               
                   
                 sodium sulphate 
               
               
                 Hydroviton ® 24 
                 Water (aqua), pentylene glycol, 
                 1.00 
                 1.00 
               
               
                   
                 glycerol, sodium lactate, 
               
               
                   
                 lactic acid, serine, urea, 
               
               
                   
                 sorbitol, sodium chloride, 
               
               
                   
                 allantoin 
               
               
                 Extrapone ® Silk GW 
                 Water (aqua), glycerol, 
                 1.00 
                 1.00 
               
               
                   
                 hydrolyzed silk 
               
               
                 Hydrolite ® 5 
                 Pentylene glycol 
                 4.00 
                 4.00 
               
               
                 Preservative 
                 Phenoxyethanol 
               
               
                 Actipearls Red Star # 
                 Water (aqua), propylene glycol, 
                 1.00 
                 1.00 
               
               
                 DH10402/6 
                 algin, gellan gum, xanthan 
               
               
                   
                 gum, calcium chloride, CI 
               
               
                   
                 12490 (Pigment Red 5), mica 
               
               
                   
                 (CI 77019), titanium dioxide 
               
               
                   
                 (CI 77891) 
               
               
                 Perfume oil P2, 
                 Perfume 
                 0.50 
                 — 
               
               
                 P4, P6 or P7 
               
               
                 Perfume oil P1, 
                 Perfume 
                 — 
                 0.50 
               
               
                 P3 or P5 
               
            
           
           
               
               
               
            
               
                 Herba Santa extract ( E. angustifolium ) 
                 0.2  
                 — 
               
               
                 as per Example 1 (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract ( E. californicum ) 
                 — 
                 0.25 
               
               
                 as per Example 7 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXXVII 
               
             
            
               
                   
               
               
                 Sunscreen spray (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredient 
                 INCI 
                 A 
                 B 
               
               
                   
               
               
                 Demineralized water 
                 Water (aqua) 
                 69.40  
                 69.40  
               
               
                 Glycerol 
                 Glycerol 
                 4.00 
                 4.00 
               
               
                 1,3 Butylene glycol 
                 Butylene glycol 
                 5.00 
                 5.00 
               
               
                 D-Panthenol 
                 Panthenol 
                 0.50 
                 0.50 
               
               
                 Lara Care A-200 
                 Galactoarabinan 
                 0.25 
                 0.25 
               
               
                 Baysilon oil M 10 
                 Dimethicone 
                 1.00 
                 1.00 
               
               
                 Edeta BD 
                 Disodium EDTA 
                 0.10 
                 0.10 
               
               
                 Copherol 1250 
                 Tocopheryl acetate 
                 0.50 
                 0.50 
               
               
                 Cetiol OE 
                 Dicaprylyl ether 
                 3.00 
                 3.00 
               
               
                 Neo Heliopan ® HMS 
                 Homosalate 
                 5.00 
                 5.00 
               
               
                 Neo Heliopan ® AV 
                 Ethylhexyl 
                 6.00 
                 6.00 
               
               
                   
                 methoxycinnamate 
               
               
                 Neo Heliopan ® 357 
                 Butyl methoxydibenzoyl- 
                 1.00 
                 1.00 
               
               
                   
                 methane 
               
               
                 Corapan TQ 
                 Diethylhexyl naphthalate 
                 2.00 
                 2.00 
               
               
                 Alpha Bisabolol 
                 Bisabolol 
                 0.10 
                 0.10 
               
               
                 Pemulen TR-2 
                 Acrylates/C10-30 alkyl 
                 0.25 
                 0.25 
               
               
                   
                 acrylate crosspolymer 
               
               
                 Phenoxyethanol 
                 Phenoxyethanol 
                 0.70 
                 0.70 
               
               
                 Solbrol M 
                 Methylparaben 
                 0.20 
                 0.20 
               
               
                 Solbrol P 
                 Propylparaben 
                 0.10 
                 0.10 
               
               
                 NaOH, 10% 
                 Sodium hydroxide 
                 0.60 
                 0.60 
               
               
                 Perfume oil P2, P4, P6 
                 Fragrance 
                 0.20 
                 — 
               
               
                 or P7 
               
               
                 Perfume oil P1, P3 or 
                 Fragrance 
                 — 
                 0.20 
               
               
                 P5 
               
            
           
           
               
               
               
            
               
                 Concentrated Herba Santa extract ( E. californicum ) 
                 0.10 
                 — 
               
               
                 as per Example 8 (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract ( E. angustifolium ) 
                 — 
                 0.10 
               
               
                 as per Example 4 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXVIII 
               
             
            
               
                   
               
               
                 Sunscreen milk (W/O) (amount in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredients 
                 INCI 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 Dehymuls PGPH 
                 Polyglyceryl-2 dipoly- 
                 3.00 
                 3.00 
               
               
                   
                 hydroxystearate 
               
               
                 Beeswax 8100 
                 Beeswax 
                 1.00 
                 1.00 
               
               
                 Monomuls 90-0-18 
                 Glyceryl oleate 
                 1.00 
                 1.00 
               
               
                 Zinc stearate 
                 Zinc stearate 
                 1.00 
                 1.00 
               
               
                 Cetiol SN 
                 Cetearyl isononanoate 
                 5.00 
                 5.00 
               
               
                 Cetiol OE 
                 Dicaprylyl ether 
                 5.00 
                 5.00 
               
               
                 Tegosoft TN 
                 C12-15 alkyl benzoate 
                 4.00 
                 4.00 
               
               
                 Vitamin E 
                 Tocopherol 
                 0.50 
                 0.50 
               
               
                 Neo Heliopan ® OS 
                 Ethylhexyl salicylate 
                 5.00 
                 5.00 
               
               
                 Neo Heliopan ® AV 
                 Ethylhexyl methoxycinnamate 
                 7.50 
                 7.50 
               
               
                 Uvinul ® T150 
                 Ethylhexyl triazone 
                 1.50 
                 1.50 
               
            
           
           
               
               
               
            
               
                 Demin. water 
                 Water (aqua) 
                 Ad 100 
               
            
           
           
               
               
               
               
            
               
                 Trilon BD 
                 Disodium EDTA 
                 0.10 
                 0.10 
               
               
                 Glycerol 
                 Glycerol 
                 5.00 
                 5.00 
               
               
                 Solbrol M 
                 Methylparaben 
                 0.20 
                 0.20 
               
               
                 Phenoxyethanol 
                 Phenoxyethanol 
                 0.70 
                 0.70 
               
               
                 Solbrol P 
                 Propylparaben 
                 0.10 
                 0.10 
               
               
                 Neo Heliopan ® AP 10% 
                 Disodium phenyl 
                 15.00 
                 15.00 
               
               
                 solution, neutralized 
                 dibenzimidazole 
               
               
                 with NaOH 
                 tetrasulphonate 
               
               
                 Perfume oil P2, P4, P6 or 
                 Perfume 
                 0.25 
                 — 
               
               
                 P7 
               
               
                 Perfume oil P1, P3 or P5 
                 Perfume 
                 — 
                 0.25 
               
            
           
           
               
               
               
            
               
                 Herba Santa extract ( E. angustifolium ) 
                 0.15 
                 — 
               
               
                 as per Example 1 (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract ( E. angustifolium ) 
                 — 
                 0.1 
               
               
                 as per Example 4 (10% in ethanol) 
               
            
           
           
               
               
               
               
            
               
                 Alpha bisabolol 
                 Bisabolol 
                 0.10 
                 0.10 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXXIX 
               
             
            
               
                   
               
               
                 After-Sun Gel (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredients 
                 INCI 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 SymSol ® PF-3 
                 Water (aqua), pentylene 
                 3.000 
                 3.000 
               
               
                   
                 glycol, sodium lauryl 
               
               
                   
                 sulphoacetate, sodium 
               
               
                   
                 oleoyl sarcosinate, 
               
               
                   
                 sodium chloride, 
               
               
                   
                 disodium sulphoacetate, 
               
               
                   
                 sodium oleate, sodium 
               
               
                   
                 sulphate 
               
               
                 Glycerol 99.5 P. 
                 Glycerol 
                 5.000 
                 5.000 
               
               
                 SymHelios ® 1031 
                 Benzylidene dimethoxy- 
                 0.100 
                 0.100 
               
               
                   
                 dimethylindanone 
               
               
                 Water 
                 Water (aqua) 
                 q.s.p. 100 
                 q.s.p. 100 
               
               
                 Pemulen ® TR-2 
                 Acrylates/C10-30 alkyl 
                 1.000 
                 1.000 
               
               
                   
                 acrylate crosspolymer 
               
               
                 D-Panthenol 75 W 
                 Panthenol 
                 0.500 
                 0.500 
               
               
                 SymFinity ® 1298 
                 
                   Echinacea Purpurea 
                 
                 0.100 
                 0.100 
               
               
                   
                 extract 
               
               
                 Extrapone ® 
                 Water (aqua), glycerol, 
                 1.000 
                 1.000 
               
               
                 Pearl GW 
                 hydrolyzed pearl, 
               
               
                   
                 xanthan gum 
               
               
                 Sodium hydroxide 
                 Sodium hydroxide 
                 2.500 
                 2.500 
               
               
                 10% soln. 
               
               
                 Preservatives 
                 Methyl, butyl, ethyl, 
                 1.000 
                 1.000 
               
               
                   
                 propylparaben, 
               
               
                   
                 phenoxyethanol 
               
               
                 Ethanol 96% 
                 Alcohol denat. 
                 15.000 
                 15.000 
               
               
                 Perfume oil P2, 
                 Perfume 
                 0.20 
                 — 
               
               
                 P4, P6 or P7 
               
               
                 Perfume oil P1, 
                 Perfume 
                 — 
                 0.20 
               
               
                 P3 or P5 
               
            
           
           
               
               
               
            
               
                 Herba Santa extract ( E. angustifolium ) 
                 0.1 
                 — 
               
               
                 as per Example 1 (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract 
                 — 
                 0.05 
               
               
                 ( E. angustifolium ) as per Example 
               
               
                 4 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXXX 
               
             
            
               
                   
               
               
                 After-sun lotion (amounts in % b.w.) 
               
            
           
           
               
               
               
            
               
                 Ingredients 
                 A 
                 B 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Acrylat/C10-30 alkyl acrylate crosspolymer 
                 0.4 
                 0.4 
               
               
                 Cetearyl ethylhexanoate 
                 15.0 
                 15.0 
               
               
                 Bisabolol 
                 0.2 
                 0.2 
               
               
                 Tocopheryl acetate 
                 1.0 
                 1.0 
               
               
                 Panthenol 
                 1.0 
                 1.0 
               
               
                 Alcohol 
                 15.0 
                 15.0 
               
               
                 Glycerol 
                 3.0 
                 3.0 
               
               
                 Perfume oil P2, P4, P6 or P7 
                 0.30 
                 — 
               
               
                 Perfume oil P1, P3 or P5 
                 — 
                 0.30 
               
               
                 Herba Santa extract ( E. angustifolium ) 
                 0.25 
                 — 
               
               
                 as per Example 1 (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract ( E. angustifolium ) 
                 — 
                 0.15 
               
               
                 as per Example 4 (10% in ethanol) 
               
               
                 Pentylene glycol 
                 4.0 
                 4.0 
               
               
                 Preservatives (methyl, butyl, ethyl, 
                 1.0 
                 1.0 
               
               
                 propylparaben, phenoxyethanol) 
               
            
           
           
               
               
            
               
                 Demin. water 
                 Ad 100 
               
            
           
           
               
               
               
            
               
                 Triethanolamine 
                 0.2 
                 0.2 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE XXXXI 
               
             
            
               
                   
               
               
                 Solution for wet wipes (amounts in % b.w.) 
               
            
           
           
               
               
               
               
            
               
                 Ingredients 
                 INCI 
                 A 
                 B 
               
               
                   
               
               
                 SymSol ® PF-3 
                 Water (aqua), pentylene 
                 2.00 
                 2.00 
               
               
                   
                 glycol, sodium lauryl 
               
               
                   
                 sulphoacetate, sodium 
               
               
                   
                 oleoyl sarcosinate, sodium 
               
               
                   
                 chloride, disodium 
               
               
                   
                 sulphoacetate, sodium 
               
               
                   
                 oleate, sodium sulphate 
               
               
                 Dragosantol ® 100 
                 Bisabolol 
                 0.10 
                 0.10 
               
               
                 Glycerol 99.5 P. 
                 Glycerol 
                 5.00 
                 5.00 
               
            
           
           
               
               
               
            
               
                 Water 
                 Water (aqua) 
                 Ad 100 
               
            
           
           
               
               
               
               
            
               
                 Hydrolite ® 5 
                 Pentylene glycol 
                 5.00 
                 5.00 
               
               
                 Preservative 
                 Phenoxyethanol 
               
               
                 D-Panthenol 75 W 
                 Panthenol 
                 0.80 
                 0.80 
               
               
                 DragoCalm ® 
                 Water (aqua), glycerol, 
                 1.00 
                 1.00 
               
               
                   
                   Avena sativa  (oat) 
               
               
                   
                 kernel extract 
               
               
                   Hamamelis  Distillate 
                 
                   Hamamelis virginiana 
                 
                 1.0  
                 1.00 
               
               
                   
                 (witch hazel) water, 
               
               
                   
                 water (aqua), alcohol 
               
               
                 Allplant Essence ® Org. Rose 
                 
                   Pelargonium graveolens 
                 
                 1.00 
                 1.00 
               
               
                 Geranium P 
                 flower/leaf/stem water 
               
               
                 Perfume oil P2, P4, P6 or P7 
                 Perfume 
                 0.10 
                 — 
               
               
                 Perfume oil P1, P3 or P5 
                 Perfume 
                 — 
                 0.10 
               
            
           
           
               
               
               
            
               
                 Herba Santa extract as per Example 1 
                 0.30 
                 — 
               
               
                 ( E. angustifolium ) (10% in ethanol) 
               
               
                 Concentrated Herba Santa extract ( E. californicum ) 
                 — 
                 0.20 
               
               
                 as per Example 8 (10% in ethanol) 
               
               
                   
               
            
           
         
       
     
     Test Studies 
     Example TS1 
     Test Study Anti-Inflammatory Action in LPS-Induced Human Monocytes 
     The anti-inflammatory test was performed in a cell culture system using human monocytes. Human monocytes are one of the main cell types which are involved in inflammatory processes in tissues; they are the cells which are mainly influenced by the lipopolysaccharides (LPS) produced by gram-negative bacteria. Further, they represent the first step in the cascade of the inflammatory reactions, in that they release various cytokines, e.g. interleukin-1beta, interleukin-6, interleukin-8 and tumour necrosis factor alpha (TNFα), but also other inflammation parameters (e.g. prostaglandin E2). The parameters measured here are recognized inflammation mediators. The use of primary human monocytes enables a realistic portrayal of the pathophysiological situation. 
     For the experiments, human primary monocytes were sown into 24-well plates (ca. 500,000 cells/ml in 1 ml). The cell viability was determined by means of the AlamarBlue method or by measurement of the intracellular ATP level. 
     The cells were incubated with the stimulus (LPS) for 24 hrs. Solutions of the Herba Santa extract according to Example 1 and an extract rich in erionic acid according to Example 4 were added 30 mins before the treatment with LPS. After 24 hrs, the supernatant was removed, centrifuged and investigated according to the operating instructions of the particular manufacturer of the immunoassay used. The results are shown in  FIG. 2   a  (Herba Santa extract according to Example 1) and  FIG. 2   b  (extract rich in erionic acid according to Example 4). 
     Adding of the Herba Santa extract according to Example 1 to cells treated with LBS led to a serious reduction of the determined inflammation markers. The effect using the extract rich in erionic acid according to Example 4 were even more significant. 
     Example TS2 
     Anti-Inflammatory Action in Human Gingival Fibroblastic Cells (HGF-1) 
     Human gingival fibroblastic cells (HGF-1) were sowed out in 24-well plates with 15,000 cells per well and cultivated for 3 to 5 days. DNEM containing 10% FBS, 1% penicillin/streptomycin and 4% glutamine was used as the medium. For determination of the anti-inflammatory action the cells were incubated with 10 μg/ml PG-LPS for 6 and 9 hrs. Subsequently, the release of IL-6 and IL-8 per magnetic bead was determined (Procarta, Affimetrix) using a MAGPIX equipment (Merck-Millipore) and analysed using the Milliplex software (Merck Millipore). In each case 4 samples with two technical replicates were measured. In addition to this control the cells were co-incubated with
     (a) 10 μg/ml PG-LPS and also with   (b) solutions of the Herba Santa extract according to Example 1 (HS, containing 21.7% HED, 0.1 μM, 1 μM and 10 μM calculated on HED);   (c) the flavonoid fraction (“FF”) obtained as a by-product according to Example 4 (containg 41.5% HED, 0,1 μM, 1 μM and 10 μM calculated on HED);   (d) the extract rich in erionic acid (“ES”) according to Example 4 or isolated erionic acid B (according to Example 2) and   (e) erionic acid C according to Example 3 (each 0,1 μM, 1 μM and 10 μM).   

     After incubation the cell culture medium was transferred into an Eppendorf reaction vessel and at 4° C. for 10 min subjected to centrifugation (1000×g) in order to separate the cell depris. The upper layer was stored at −80° C. until the analysis started. The results of the release of IL-6 and 
     IL-8 after 6 and 9 hrs are shown in  FIGS. 3   a  to  3   e . In some of the tested concentrations and after certain times of treatment adding of the Herba Santa extract according to Example 1 also led to a reduction of IL-6 and IL-8 release ( FIG. 3   a ). Adding of the extracts FF and ES led to a significant reduction in IL release ( FIGS. 3   b ,  3   c ); the same is true for the addition of erionic acid B ( FIG. 3   d ). The most significant reduction could be shown for erinoic acid C ( FIG. 3   e ): at higher concentration the release of IL-6 and IL-8 was almost completely inhibited. 
     In the following Tables 3a to 3e the asterisks mean: *p&lt;0,05, **p&lt;0,01, ***p&lt;0,001. 
     
       
         
           
               
             
               
                 TABLE 3a 
               
             
            
               
                   
               
               
                 Release of IL-6 and IL-8 by HGF-1 cells after stimulation with 10 μg/ml 
               
               
                 PG-LPS or respectively co-incubation with Herba Santa extract of Example 
               
               
                 1 (HS, concentration calculated on contained Homoeriodictyol, HED) 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                 IL-6 
                   
                 IL-8 
               
               
                   
                 IL-6 
                 Standard 
                 IL-8 
                 Standard 
               
               
                 Test Compound 
                 T/C [%] 
                 Deviation 
                 T/C [%] 
                 Deviation 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 10 μg/ml LPS control - 6 h 
                 100.00 
                 35.66 
                 98.91 
                 9.06 
               
               
                 10 μg/ml LPS + 0.1 μM HED in HS - 6 h 
                 74.54 
                 18.31 
                 117.33* 
                 9.78 
               
               
                 10 μg/ml LPS + 1 μM HED in HS - 6 h 
                 61.90** 
                 13.48 
                 120.57 
                 34.88 
               
               
                 10 μg/ml LPS + 10 μM HED in HS - 6 h 
                 47.97** 
                 15.55 
                 131.33** 
                 37.98 
               
               
                 10 μg/ml LPS-control - 9 h 
                 100.00 
                 10.50 
                 100.00 
                 13.67 
               
               
                 10 μg/ml LPS + 0.1 μM HED in HS - 9 h 
                 127.27 
                 56.92 
                 101.45 
                 15.92 
               
               
                 10 μg/ml LPS + 1 μM HED in HS - 9 h 
                 127.80* 
                 26.77 
                 139.93* 
                 33.49 
               
               
                 10 μg/ml LPS + 10 μM HED in HS - 9 h 
                 73.12 
                 20.93 
                 62.92*** 
                 8.38 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 3b 
               
             
            
               
                   
               
               
                 Release of IL-6 and IL-8 by HGF-1 cells after stimulation with 10 μg/ml PG- 
               
               
                 LPS or respectively co-incubation with the flavonoid extract (FF) of Example 4 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                 IL-6 
                   
                 IL-8 
               
               
                   
                 IL-6 
                 Standard 
                 IL-8 
                 Standard 
               
               
                 Test Compound 
                 T/C [%] 
                 Deviation 
                 T/C [%] 
                 Deviation 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 10 μg/ml LPS-Control - 6 h 
                 100.00 
                 35.66 
                 98.91 
                 9.06 
               
               
                 10 μg/ml LPS + 0.1 μM HED in FF - 6 h 
                 56.58** 
                 12.39 
                 79.04 
                 51.34 
               
               
                 10 μg/ml LPS + 1 μM HED in FF - 6 h 
                 32.93*** 
                 9.55 
                 40.99*** 
                 7.95 
               
               
                 10 μg/ml LPS + 10 μM HED in flavonoid 
                 63.65* 
                 12.09 
                 41.76*** 
                 9.50 
               
               
                 fraction - 6 h 
               
               
                 10 μg/ml LPS-Control - 9 h 
                 100.00 
                 10.50 
                 100.00 
                 13.67 
               
               
                 10 μg/ml LPS + 0.1 μM HED in FF - 9 h 
                 60.87** 
                 22.17 
                 46.73*** 
                 16.38 
               
               
                 10 μg/ml LPS + 1 μM HED in FF - 9 h 
                 55.88* 
                 36.35 
                 38.73*** 
                 36.35 
               
               
                 10 μg/ml LPS + 10 μM HED in FF - 9 h 
                 57.15*** 
                 24.38 
                 57.23*** 
                 18.80 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 3c 
               
             
            
               
                   
               
               
                 Release of IL-6 and IL-8 by HGF-1 cells after stimulation with 10 μg/ml PG-LPS 
               
               
                 or respectively co-incubation with the extract rich in erionic acid (ES) of Example 4 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                 IL-6 
                   
                 IL-8 
               
               
                   
                 IL-6 
                 Standard 
                 IL-8 
                 Standard 
               
               
                 Test Compound 
                 T/C [%] 
                 Deviation 
                 T/C [%] 
                 Deviation 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 10 μg/ml LPS-Control - 6 h 
                 100.00 
                 35.66 
                 98.91 
                 9.06 
               
               
                 10 μg/ml LPS + 1 μg/ml ES - 6 h 
                 101.00 
                 5.25 
                 117.56 
                 25.82 
               
               
                 10 μg/ml LPS + 10 μg/ml ES - 6 h 
                 69.31* 
                 14.01 
                 68.29** 
                 13.30 
               
               
                 10 μg/ml LPS + 100 μg/ml ES - 6 h 
                 67.24* 
                 13.42 
                 50.18** 
                 11.27 
               
               
                 10 μg/ml LPS-Control - 9 h 
                 100.00 
                 10.50 
                 100.00 
                 13.67 
               
               
                 10 μg/ml LPS + 1 μg/ml ES - 9 h 
                 38.86*** 
                 11.18 
                 67.36* 
                 25.84 
               
               
                 10 μg/ml LPS + 10 μg/ml ES - 9 h 
                 46.62** 
                 13.47 
                 78.74 
                 16.33 
               
               
                 10 μg/ml LPS + 100 μg/ml ES - 9 h 
                 42.00*** 
                 13.20 
                 21.99*** 
                 5.38 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 3d 
               
             
            
               
                   
               
               
                 Release of IL-6 and IL-8 by HGF-1 cells after stimulation with 10 μg/ml 
               
               
                 PG-LPS or respectively co-incubation with the erionic acid B of Example 2 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                 IL-6 
                   
                 IL-8 
               
               
                   
                 IL-6 
                 Standard 
                 IL-8 
                 Standard 
               
               
                 Test Compound 
                 T/C [%] 
                 Deviation 
                 T/C [%] 
                 Deviation 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 10 μg/ml LPS-Control - 6 h 
                 100.00 
                 35.66 
                 98.91 
                 9.06 
               
               
                 10 μg/ml LPS + 1 μg/ml erionic acid B - 6 h 
                 61.93* 
                 19.98 
                 79.91 
                 14.03 
               
               
                 10 μg/ml LPS + 10 μg/ml erionic acid B - 6 h 
                 102.30 
                 2.56 
                 134.54** 
                 19.89 
               
               
                 10 μg/ml LPS + 100 μg/ml erionic acid B - 6 h 
                 41.30** 
                 5.29 
                 46.30** 
                 19.81 
               
               
                 10 μg/ml LPS-Control - 9 h 
                 100.00 
                 10.50 
                 100.00 
                 13.67 
               
               
                 10 μg/ml LPS + 1 μg/ml erionic acid B - 9 h 
                 77.51* 
                 13.53 
                 77.33 
                 49.22 
               
               
                 10 μg/ml LPS + 10 μg/ml erionic acid B - 9 h 
                 61.47*** 
                 10.05 
                 71.35 
                 28.24 
               
               
                 10 μg/ml LPS + 100 μg/ml erionic acid B - 9 h 
                 102.74 
                 25.02 
                 116.34 
                 40.91 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 3e 
               
             
            
               
                   
               
               
                 Release of IL-6 and IL-8 by HGF-1 cells after stimulation with 10 μg/ml 
               
               
                 PG-LPS or respectively co-incubation with the erionic acid C of Example 3 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                 IL-6 
                   
                 IL-8 
               
               
                   
                 IL-6 
                 Standard 
                 IL-8 
                 Standard 
               
               
                 Test Compound 
                 T/C [%] 
                 Deviation 
                 T/C [%] 
                 Deviation 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 10 μg/ml LPS-Control - 6 h 
                 100.00 
                 35.66 
                 98.91 
                 9.06 
               
               
                 10 μg/ml LPS + 1 μg/ml erionic acid C - 6 h 
                 76.66 
                 22.32 
                 94.59 
                 23.76 
               
               
                 10 μg/ml LPS + 10 μg/ml erionic acid C - 6 h 
                 65.22* 
                 32.24 
                 62.47* 
                 25.75 
               
               
                 10 μg/ml LPS + 100 μg/ml erionic acid C - 6 h 
                 5.11*** 
                 3.41 
                 0.67*** 
                 0.64 
               
               
                 10 μg/ml LPS-Control - 9 h 
                 100.00 
                 10.50 
                 100.00 
                 13.67 
               
               
                 10 μg/ml LPS + 1 μg/ml erionic acid C - 9 h 
                 53.26** 
                 22.53 
                 39.13*** 
                 13.83 
               
               
                 10 μg/ml LPS + 10 μg/ml erionic acid C - 9 h 
                 56.22*** 
                 15.62 
                 39.00*** 
                 13.38 
               
               
                 10 μg/ml LPS + 100 μg/ml erionic acid C - 9 h 
                 7.67*** 
                 6.85 
                 1.49*** 
                 1.83