Patent Publication Number: US-2012046292-A1

Title: Diacylethylenediamine compound

Description:
TECHNICAL FIELD 
     The present invention relates to a diacylethylenediamine compound which is useful as an active ingredient of a pharmaceutical composition, for example, a pharmaceutical composition for treating obesity. 
     BACKGROUND ART 
     Obesity is a state in which there is an imbalance between energy intake and energy consumption in a biological body, and in which excess energy is over-accumulated in the adipose tissues as neutral fats, mainly triglycerides, and is deeply related to the onset and progress of diseases such as insulin resistance, diabetes, arteriosclerosis, non-alcoholic steatohepatitis, or hypertension. Further, it is known that accumulation of excess triglycerides in the liver, muscles, and the like, as well as the adipose tissues, causes dysfunction in these tissues. Recently, the number of patients suffering from obesity is increasing as lifestyles have changed, but the methods for treating obesity are limited. Therefore, there is a demand for the development of a new drug for treating obesity. 
     DGAT is an enzyme involved in a final step of a triglyceride biosynthesis pathway, that is, a reaction for producing triglyceride from diacylglycerol and fatty acyl-CoA, and the subtypes, DGAT1 and DGAT2, have been reported. It has been clarified that the amino acid sequence of DGAT1 has a low homology with DGAT2 and has a high homology with ACAT (Proc. Nat. Acad. Sci. 95:13018-13023, 1998; J. Biol. Chem. 276:38870-38876, 2001). As a phenotype of a DGAT1 knockout mice, resistance to high-fat diet-induced obesity, improved insulin resistance, increased leptin sensitivity, decrease in the amount of fat in the liver, and increased energy consumption, and the like have been reported (Nature Genetics 25: 87-90, 2000; J. Clin. Invest. 109:1049-1055, 2002). In addition, DGAT1 hetero-knockout mice show an intermediate phenotype between a wild type and homo-deficient mice (Arterioscler. Thromb. Vase. Biol. 25; 482-486, 2005), and accordingly, DGAT1 inhibition is considered to be promising as a target for drug therapy for obesity, type II diabetes mellitus, fatty liver, and other related diseases derived from these diseases. 
     For example, it has been reported that a compound represented by the following formula has a DGAT1 inhibitory action (Patent Document 1). 
     
       
         
         
             
             
         
       
     
     [refer to the patent publication for the symbols in the formula]. 
     Furthermore, it has been reported that a compound represented by the following formula has a DGAT1 inhibitory action (Patent Document 2). 
     
       
         
         
             
             
         
       
     
     [refer to the patent publication for the symbols in the formula]. 
     Furthermore, it has been reported that a compound represented by the following formula has a DGAT1 inhibitory action (Patent Document 3). 
     
       
         
         
             
             
         
       
     
     [refer to the patent publication for the symbols in the formula]. 
     Moreover, in addition to the above, a compound having a DGAT1 inhibitory action has been reported (Patent Document 4, Patent Document 5, Patent Document 6, and Patent Document 7). 
     Furthermore, there have been reports on several diacylethylenediamines (Patent Document 8 and Non-Patent Document 1). 
     However, there is no disclosure or suggestion of the compound of the formula (I) or a salt thereof according to the present invention in any of the above literature. 
     RELATED ART 
     Patent Document 
     
         
         [Patent Document 1] Pamphlet of International Publication WO 2006/082952 
         [Patent Document 2] Pamphlet of International Publication WO 2008/011130 
         [Patent Document 3] Pamphlet of International Publication WO 2008/011131 
         [Patent Document 4] Pamphlet of International Publication WO 2007/141517 
         [Patent Document 5] Pamphlet of International Publication WO 2007/138304 
         [Patent Document 6] Pamphlet of International Publication WO 2007/138311 
         [Patent Document 7] Pamphlet of International Publication WO 2006/064189 
         [Patent Document 8] Pamphlet of International Publication WO 2009/076618 
       
    
     Non-Patent Document 
     
         
         [Non-Patent Document 1] Chemical Research in Chinese Universities, 2009, Vol. 25, No. 2, pp. 178 to 182 
       
    
     SUMMARY OF THE INVENTION 
     Problems to Be Solved by the Invention 
     A diacylethylenediamine compound which is useful as an active ingredient of a pharmaceutical composition, for example, a pharmaceutical composition for treating obesity is provided. 
     Means for Solving the Problems 
     The present inventors have extensively studied a compound having a DGAT1 inhibitory action, and as a result, they have found that the diacylethylenediamine compound of the present invention has a DGAT1 inhibitory action, thereby completing the present invention. 
     That is, the present invention relates to a compound of the formula (I) or a salt thereof, and a pharmaceutical composition comprising a compound of the formula (I) or a salt thereof, and a pharmaceutically acceptable excipient. 
     
       
         
         
             
             
         
       
     
     (wherein A represents aryl which may be substituted, cycloalkyl which may be substituted, an aromatic heterocycle which may be substituted, a non-aromatic heterocycle which may be substituted, or a group represented by the formula (II): 
     
       
         
         
             
             
         
       
     
     in which R 11  and R 12  are the same as or different from each other, and represent —H, C 1-6  alkyl, aryl which may be substituted, or C 3-8  cycloalkyl which may be substituted, provided that R 11  and R 12  are not —H at the same time, and 
     R 11  and R 12  may be combined with the nitrogen atom to which they bind to form cyclic amino which may be substituted, 
     Ring B 1  represents phenylene, pyridinediyl, naphthalenediyl, or 1,2,3,4-tetrahydronaphthalenediyl, each of which may be substituted with at least one group selected from the group consisting of —OH, C 1-6  alkyl which may be substituted with at least one halogen atom, —O—C 1-6  alkyl which may be substituted with at least one halogen atom, C 3-8  cycloalkyl, and halogen, 
     W represents —O—, a bond, —O—C 1-6  alkylene, —NH—, or C 1-6  alkylene, 
     Ring B 2  represents cyclohexanediyl, cyclopentanediyl, or a bridged ring, each of which may be substituted with C 1-6  alkyl, and in the case where W is a bond, it may represent piperidinediyl or 8-azabicyclo[3.2.1]octanediyl, 
     Y represents a bond, C 1-6  alkylene, or —O—C 1-6  alkylene, and 
     Z represents —CO 2 H or a biological equivalent thereof; carbamoyl which may be substituted with one or two groups selected from C 1-6  alkyl (in which the C 1-6  alkyl may be substituted with amino or carboxyl), phenyl and benzyl; —CO-(cyclic amino which may be substituted with one or two C 1-6  alkyl groups); —OH; amino which may be substituted with one or two C 1-6  alkyl groups; —NH—C(═O)—C 1-6  alkyl; or —NH—C(═O)—C 3-8  cycloalkyl). 
     In this regard, when the symbols in any of the chemical formulae in the present specification are also used in other formulae, the same symbols denote the same meanings, unless there is no specific instruction. 
     Furthermore, the present invention relates to a pharmaceutical composition for preventing or treating obesity, including a compound or a salt thereof of the formula (I). Further, the pharmaceutical composition includes an agent for preventing or treating obesity, including the compound of the formula (I) or a salt thereof. 
     In addition, the present invention relates to use of the compound of the formula (I) or a salt thereof for the manufacture of a pharmaceutical composition for preventing or treating obesity, the compound of the formula (I) or a salt thereof for use in the prevention or treating of obesity and a method for preventing or treating obesity, comprising administering to a subject an effective amount of the compound of the formula (I) or a salt thereof. Here, the “subject” refers to humans or other animals in need of the prevention or treatment thereof; and in a certain embodiment, humans in need of the prevention or treatment thereof. 
     Effects of the Invention 
     The compound of the formula (I) or a salt thereof has a DGAT1 inhibitory action, and can be used as an agent for preventing and/or treating obesity. 
    
    
     EMBODIMENTS FOR CARRYING OUT THE INVENTION 
     Hereinafter, the present invention will be described in detail. 
     In the present specification, the “alkyl” includes a straight alkyl and a branched alkyl. Accordingly, the “C 1-6  alkyl” is a straight or a branched alkyl having 1 to 6 carbon atoms, for example, methyl, ethyl, propyl, isopropyl, butyl, tert-butyl, pentyl, hexyl, or the like, in another embodiment, methyl, ethyl, propyl, or isopropyl, in a further embodiment, methyl or ethyl, and in a further embodiment, methyl. 
     The “alkylene” is a divalent group formed by the removal of any one hydrogen atom of the “alkyl” above. Accordingly, the “C 1-6  alkylene” is a straight or a branched alkylene having 1 to 6 carbon atoms, for example, methylene, ethylene, trimethylene, tetramethylene, pentamethylene, hexamethylene, methylmethylene, dimethylmethylene, ethylmethylene, methylethylene, dimethylethylene, ethylethylene, or the like, in another embodiment, methylene or ethylene, and in a further embodiment, methylene. 
     The “aryl” is a monocyclic to tricyclic aromatic hydrocarbon ring group having 6 to 14 carbon atoms. Specific examples thereof include phenyl and naphthyl, in another embodiment, phenyl, and in a further embodiment, naphthyl. 
     The “cycloalkyl” is a saturated hydrocarbon ring group having 3 to 8 ring members, the cycloalkyl may have a bridge and may be fused with a benzene ring, and a proportion of the bonds may be unsaturated. Specific examples thereof include cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, cyclooctadienyl, norbornyl, bicyclo[2.2.2]octyl, bicyclo[3.1.1]heptyl, bicyclo[4.1.0]heptyl, bicyclo[3.2.1]octyl, adamantyl, indanyl, indenyl, 1,2-dihydronaphthyl, 1,2,3,4-tetrahydronaphthyl, and the like. 
     The “bridged ring” is a divalent group of a saturated hydrocarbon ring having 6 to 10 ring members containing a bridge. Specific examples thereof include divalent groups such as bicyclo[3.1.0]hexane, norbornane, bicyclo[2.2.2]octane, bicyclo[3.1.1]heptane, bicyclo[4.1.0]heptane, bicyclo[3.2.1]octane, adamantane, and the like. 
     The “aromatic heterocycle” is an aromatic heterocycle group having 5 to 6 ring members, containing at least one hetero atom selected from O, N, and S as a ring-constituting atom, and the aromatic heterocycle may be fused with a benzene ring or a thiophene ring. Specific examples thereof include pyrrolyl, furyl, thienyl, pyrazolyl, imidazolyl, oxazolyl, thiazolyl, oxadiazolyl, thiadiazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyradyl, indolyl, isoindolyl, benzofuryl, benzothienyl, indazolyl, benzoimidazolyl, benzooxazolyl, benzothiazolyl, quinolyl, isoquinolyl, cinnolinyl, phthalazinyl, quinazolinyl, quinoxalinyl, thienopyridyl, thienopyrimidinyl, thienopyrazyl, and the like. 
     The “non-aromatic heterocycle” is a non-aromatic heterocycle group having 3 to 7 ring members, containing at least one hetero atom selected from O, N, and S as a ring-constituting atom, the non-aromatic heterocycle may be fused with a benzene ring, a thiophene ring, or a cyclohexane ring, and a proportion of the bonds may be unsaturated. Further, the sulfur atom that is a ring-constituting atom may be oxidized. Specific examples of the non-aromatic heterocycle include aziridinyl, azetidinyl, piperidinyl, azepanyl, oxetanyl, tetrahydrofuryl, tetrahydropyranyl, thietanyl, tetrahydrothienyl, tetrahydrothiopyranyl, 1,1-dioxidetetrahydrothiopyranyl, oxazolidinyl, thiazolidinyl, 1,1-dioxidethiazolidinyl, isoxazolidinyl, isothiazolidinyl, 1,1-dioxideisothiazolidinyl, piperazinyl, morpholinyl, thiomorpholinyl, 1,1-dioxidethiomorpholinyl, dioxanyl, indolinyl, isoindolinyl, dihydroquinolyl, tetrahydroquinolyl, dihydroisoquinolyl, tetrahydroisoquinolyl, decahydroisoquinolyl, tetrahydrothienopyridyl, tetrahydrobenzoazepine, tetrahydrobenzodiazepine, dihydrobenzofuryl, dihydrobenzothienyl, dihydrobenzopyranyl, dihydrobenzothiopyranyl, dihydrobenzodioxynyl, benzodioxolyl, and the like. 
     The “cyclic amino” is a non-aromatic heterocycle group having a nitrogen atom among the above “non-aromatic heterocycles”, which has a bonding arm on the nitrogen atom, and specific examples thereof include pyrrolidin-1-yl, piperidin-1-yl, azepan-1-yl, oxazolidin-3-yl, thiazolidin-3-yl, 1,1-dioxidethiazolidin-3-yl, isoxazolidin-2-yl, isothiazolidin-2-yl, 1,1-dioxideisothiazolidin-2-yl, piperazin-1-yl, morpholin-4-yl, thiomorpholin-4-yl, 1,1-dioxidethiomorpholin-4-yl, indolin-1-yl, isoindolin-2-yl, 1,2,3,4-tetrahydroquinolin-1-yl, 1,2,3,4-tetrahydroisoquinolin-2-yl, decahydroquinolin-1-yl, decahydroquinolin-2-yl, 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-5-yl, and the like. 
     The “halogen” means —F, —Cl, —Br, or —I, in another embodiment, —F, —Cl, or —Br, in a further embodiment, —F or —Cl, and in a further embodiment, —F. 
     The “—CO 2 H or a biological equivalent thereof” means —CO 2 H, or another atom or an atom group, which is electronically or sterically configuration equivalent to —CO 2 H, is capable of releasing acidic protons, and has common biological properties. Example thereof include —CO 2 H, —CO—NH—OH, —CO—NH—O—C 1-6  alkyl, —CO—NH—CN, —CO—NH—SO 2 —C 1-6  alkyl, —CO—NH—SO 2 —N(C 1-6  alkyl) 2 , or tetrazolyl, oxadiazolonyl, oxadiazolethionyl, oxathiadiazolyl, thiadiazolonyl, triazolethionyl, hydroxyisoxazole, and the like, in another embodiment, —CO 2 H, —CO—NH—SO 2 —C 1-6  alkyl, —CO—NH—SO 2 —N(C 1-6  alkyl) 2 , and tetrazolyl, and in a further embodiment, —CO 2 H. 
     An embodiment of “phenylene” is 1,4-phenylene, an embodiment of “pyridinediyl” is pyridine-2,5-diyl or pyridine-3,6-diyl, an embodiment of “naphthalenediyl” is naphthalene-2,6-diyl or naphthalene-3,7-diyl, an embodiment of “1,2,3,4-tetrahydronaphthalenediyl” is 1,2,3,4-tetrahydronaphthalene-2,6-diyl or 1,2,3,4-tetrahydronaphthalene-3,7-diyl, an embodiment of “cyclohexanediyl” is cyclohexane-1,4-diyl, an embodiment of “cyclopentanediyl” is cyclopentane-1,3-diyl, an embodiment of “piperidinediyl” is piperidine-1,4-diyl, and an embodiment of “8-azabicyclo[3.2.1]octanediyl” is 8-azabicyclo[3.2.1]octane-3,8-diyl. 
     In the present specification, the expression “which may be substituted” represents “which is not substituted” or “which is substituted with 1 to 5 substituents”. Further, if it has a plurality of substituents, the substituents may be the same as or different from each other. 
     Examples of the acceptable substituent in the “aryl which may be substituted”, “cycloalkyl which may be substituted”, “aromatic heterocycle which may be substituted”, and “non-aromatic heterocycle which may be substituted” in A of the formula (I) include the following: 
     (1) halogen, 
     (2) C 1-6  alkyl which may be substituted with at least one group selected from the group consisting of halogen, aryl, —OH, —O—C 1-6  alkyl, —O-aryl, C 3-8  cycloalkyl, and oxo, 
     (3) —O—C 1-6  alkyl or —S—C 1-6  alkyl, each of which may be substituted with at least one group selected from the group consisting of halogen, C 3-8  cycloalkyl, —O—C 1-6  alkyl, aryl (in which the aryl may be substituted with at least one halogen atom), and a non-aromatic heterocycle, 
     (4) aryl or —O-aryl, each of which may be substituted with at least one group selected from the group consisting of halogen, C 1-6  alkyl (in which the C 1-6  alkyl may be substituted with at least one halogen atom), —O—C 1-6  alkyl (in which the C 1-6  alkyl may be substituted with at least one halogen atom), C 3-8  cycloalkyl, and cyano, 
     (5) C 3-8  cycloalkyl or —O—C 3-8  cycloalkyl, each of which may be substituted with at least one C 1-6  alkyl group, 
     (6) an aromatic heterocycle or —O-aromatic heterocycle, each of which may be substituted with at least one group selected from the group consisting of halogen, C 1-6  alkyl, and C 3-8  cycloalkyl, 
     (7) amino or cyclic amino, each of which may be substituted with at least one group selected from the group consisting of C 1-6  alkyl (in which the C 1-6  alkyl may be substituted with at least one aryl) and aryl, 
     (8) —CO—C 1-6  alkyl or —SO 2 —C 1-6  alkyl, each of which may be substituted with at least one halogen atom, and 
     (9) —OH. 
     Examples of the acceptable substituent in the “aryl which may be substituted”, “cycloalkyl which may be substituted”, and “cyclic amino which may be substituted” in R 11  or R 12  of the formula (I) include: 
     (1) halogen, 
     (2) C 1-6  alkyl which may be substituted with at least one group selected from the group consisting of halogen, aryl, —OH, —O—C 1-6  alkyl, —O-aryl, C 3-8  cycloalkyl, and oxo, 
     (3) —O—C 1-6  alkyl or —S—C 1-6  alkyl, each of which may be substituted with at least one group selected from the group consisting of halogen, C 3-8  cycloalkyl, —O—C 1-6  alkyl, aryl (in which the aryl may be substituted with at least one halogen atom), and a non-aromatic heterocycle, 
     (4) aryl or —O-aryl, each of which may be substituted with at least one group selected from the group consisting of halogen, C 1-6  alkyl (in which the C 1-6  alkyl may be substituted with at least one halogen atom), —O—C 1-6  alkyl (in which the C 1-6  alkyl may be substituted with at least one halogen atom), C 3-8  cycloalkyl, and cyano, and 
     (5) C 3-8  cycloalkyl or —O—C 3-8  cycloalkyl, each of which may be substituted with at least one C 1-6  alkyl group. 
     Embodiments of the compound of the formula (I) or a salt thereof are shown below. 
     (1) The compound or a salt thereof, wherein A is aryl which may be substituted, cycloalkyl which may be substituted, an aromatic heterocycle which may be substituted, a non-aromatic heterocycle which may be substituted, or a group represented by the formula (II), R 11  and R 12  are the same as or different from each other and are —H, aryl which may be substituted, or C 3-8  cycloalkyl which may be substituted, provided that R 11  and R 12  are not —H at the same time, in which R 11  and R 12  may be combined with the nitrogen atom to which the bind to form cyclic amino which may be substituted; in another embodiment, the compound or a salt thereof, wherein A is phenyl, naphthyl, thienyl, or benzothienyl, each of which may be substituted with at least one group selected from the group consisting of fluoro, chloro, methyl, and cyclopropyl; in a further embodiment, the compound or a salt thereof, wherein A is naphthyl; in a further embodiment, the compound or a salt thereof, wherein A is thienyl which may be substituted with halogen; in the further embodiment, the compound or a salt thereof, wherein A is benzothienyl which may be substituted with halogen; and in a further embodiment, the compound or a salt thereof, wherein A is phenyl which may be substituted with at least one group selected from the group consisting of chloro, methyl, and cyclopropyl. 
     (2) The compound or a salt thereof, wherein Ring B 1  is a group represented by the formula (III): 
     
       
         
         
             
             
         
       
     
     wherein X 1  represents N or CR 3 , X 2  represents N or CR 4 , and R 1 , R 2 , R 3  and R 4  are the same as or different from each other and represent —H, —OH, C 1-6  alkyl which may be substituted with at least one halogen atom, —O—C 1-6  alkyl which may be substituted with at least one halogen atom, or C 3-8  cycloalkyl or halogen; in another embodiment, the compound or a salt thereof, wherein Ring B 1  is 1,4-phenylene which may be substituted with at least one halogen atom; and in a further embodiment, the compound or a salt thereof, wherein Ring B 1  is 1,4-phenylene which may be substituted with one or two fluorine atoms. 
     (3) The compound or a salt thereof, wherein W is —O— or a bond; and in another embodiment, the compound or a salt thereof, wherein W is —O—. 
     (4) The compound or a salt thereof, wherein Ring B 2  is cyclohexane-1,4-diyl. 
     (5) The compound or a salt thereof, wherein Y is a bond or C 1-6  alkylene, in another embodiment, the compound or a salt thereof, wherein Y is a bond or methylene; in another embodiment, the compound or a salt thereof, wherein Y is a bond; and in a further embodiment, the compound or a salt thereof, wherein Y is methylene. 
     (6) The compound or a salt thereof, wherein Z is —CO 2 H or a biological equivalent thereof, or —CONH 2 , and in another embodiment, the compound or a salt thereof, wherein Z is —CO 2 H. 
     (7) The compound or a salt thereof, which is a combination of two or more of the groups described in (1) to (6) above. 
     The compound or a salt thereof as described above in (7), which is a combination of two or more of the groups described in (1) to (6) above, is included in the present invention, but the specific examples thereof also include the following embodiments. 
     (8) The compound or a salt thereof, wherein A is aryl which may be substituted, cycloalkyl which may be substituted, an aromatic heterocycle which may be substituted, a non-aromatic heterocycle which may be substituted, or a group represented by the formula (II), and R 11  and R 12  are the same as or different from each other and are —H, aryl which may be substituted, or C 3-8  cycloalkyl which may be substituted, provided that R 11  and R 12  are not —H at the same time, in which R 11  and R 12  may be combined with nitrogen atom to which they bind form a cyclic amino which may be substituted, Ring B 1  is a group represented by the formula (III), X 1  is N or CR 3 , X 2  is N or CR 4 , and R 1 , R 2 , R 3  and R 4  are the same as or different from each other and are —H, —OH, C 1-6  alkyl which may be substituted with at least one halogen atom, —O—C 1-6  alkyl which may be substituted with at least one halogen atom, C 3-8  cycloalkyl or halogen, W is —O— or a bond, Ring B 2  is cyclohexane-1,4-diyl, Y is a bond or C 1-6  alkylene, and Z is —CO 2 H or a biological equivalent thereof, or —CONH 2 . 
     (9) The compound or a salt thereof, wherein Ring B 1  is 1,4-phenylene which may be substituted with at least one halogen atom, W is —O—, Ring B 2  is cyclohexane-1,4-diyl, Y is a bond or methylene, and Z is —CO 2 H. 
     (10) The compound or a salt thereof according to (9), wherein Ring B 1  is 1,4-phenylene which may be substituted with one or two fluorine atoms. 
     (11) The compound or a salt thereof according to (10), wherein Y is a bond. 
     Examples of the specific compounds encompassed by the compound of the formula (I) or a salt thereof include:
     cis-4-[4-({2-[(4-cyclopropylbenzoyl)amino]ethyl}carbamoyl)phenoxy]cyclohexanecarboxylic acid,   cis-4-(4-{[2-(2-naphthoylamino)ethyl]carbamoyl}phenoxy)cyclohexanecarboxylic acid,   cis-4-[4-({2-[(4-chloro-3-methylbenzoyl)amino]ethyl}carbamoyl)phenoxy]cyclohexanecarboxylic acid,   cis-4-(3-fluoro-4-{[2-(2-naphthoylamino)ethyl]carbamoyl}phenoxy)cyclohexanecarboxylic acid,   cis-4-(3,5-difluoro-4-{[2-(2-naphthoylamino)ethyl]carbamoyl}phenoxy)cyclohexanecarboxylic acid,   cis-4-(2,3-difluoro-4-{[2-(2-naphthoylamino)ethyl]carbamoyl}phenoxy)cyclohexanecarboxylic acid,   cis-4-(2,5-difluoro-4-{[2-(2-naphthoylamino)ethyl]carbamoyl}phenoxy)cyclohexanecarboxylic acid,   cis-4-{4-[(2-{[(3-chloro-1-benzothiophen-2-yl)carbonyl]amino}ethyl)carbamoyl]phenoxy}cyclohexanecarboxylic acid,   cis-4-{4-[(2-{[(5-chlorothiophen-2-yl)carbonyl]amino}ethyl)carbamoyl]-2,3-difluorophenoxy}cyclohexanecarboxylic acid,   cis-4-{3-fluoro-4-[(2-{[(5-fluoro-1-benzothiophen-2-yl)carbonyl]amino}ethyl)carbamoyl]phenoxy}cyclohexanecarboxylic acid,   [cis-4-(2,5-difluoro-4-{[2-(2-naphthoylamino)ethyl]carbamoyl}phenoxy)cyclohexyl]acetic acid, and   

     salts thereof. 
     The compound of the formula (I) may exist in the form of tautomers or geometrical isomers depending on the kind of substituents. In the present specification, the compound of the formula (I) shall be described in only one form of isomers, yet the present invention includes other isomers, each of separatedisomers, or a mixture thereof. In addition, the compound of the formula (I) may have asymmetric carbon atoms or axial asymmetry in some cases, and correspondingly, it may exist in the form of optical isomers. The present invention includes both an separated form of the optical isomers of the compound of the formula (I) or a mixture thereof. 
     Moreover, the present invention also includes a pharmaceutically acceptable prodrug of the compound of the formula (I). The pharmaceutically acceptable prodrug is a compound having a group that can be converted into an amino group, a hydroxyl group, a carboxyl group, or the like through solvolysis or under physiological conditions. Examples of the group forming the prodrug include the groups described in Prog. Med., 5, 2157-2161 (1985) and Pharmaceutical Research and Development, Hirokawa Publishing Company (1990), Vol. 7, Drug Design 163-198. 
     Furthermore, the salt of the compound of the formula (I) is a pharmaceutically acceptable salt of the compound of the formula (I) and may form an acid addition salt or a salt with a base depending on the kind of substituents. Specific examples thereof include acid addition salts with inorganic acids such as hydrochloric acid, hydrobromic acid, hydroiodic acid, sulfuric acid, nitric acid, phosphoric acid, and the like, and with organic acids such as formic acid, acetic acid, propionic acid, oxalic acid, malonic acid, succinic acid, fumaric acid, maleic acid, lactic acid, malic acid, mandelic acid, tartaric acid, dibenzoyltartaric acid, ditolyltartaric acid, citric acid, methanesulfonic acid, ethanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, aspartic acid, glutamic acid, and the like, and salts with inorganic bases such as sodium, potassium, magnesium, calcium, aluminum, and the like or organic bases such as methylamine, ethylamine, ethanolamine, lysine, ornithine, and the like, salts with various amino acids or amino acid derivatives such as acetylleucine and the like, ammonium salts, etc. 
     In addition, the present invention also includes various hydrates or solvates, and polymorphic crystalline forms of the compound of the formula (I) and a salt thereof. In addition, the present invention also includes compounds labeled with various radioactive or non-radioactive isotopes. 
     (Preparation Methods) 
     The compound of the formula (I) and a salt thereof can be prepared using the characteristics based on the basic structure or the type of substituents thereof and by applying various known synthesis methods. During the preparation, replacing the relevant functional group with a suitable protective group (a group that can be easily converted into the functional group) at the stage from starting material to an intermediate may be effective depending on the type of the functional group in the production technology in some cases. The protective group for such a functional group may include, for example, the protective groups described in “Greene&#39;s Protective Groups in Organic Synthesis (4 th  Ed., 2006)”, P. G. M. Wuts and T. W. Greene, and one of these may be selected and used as necessary depending on the reaction conditions. In this kind of method, a desired compound can be obtained by introducing the protective group, by carrying out the reaction and by eliminating the protective group as necessary. 
     In addition, the prodrug of the compound of the formula (I) can be produced by introducing a specific group or by carrying out the reaction using the resulting compound of the formula (I) at the stage from a starting material to an intermediate, just as in the case of the above-mentioned protective group. The reaction can be carried out using methods known to those skilled in the art, such as ordinary esterification, amidation, dehydration, and the like. 
     Hereinbelow, the representative preparation methods for the compound of the formula (I) will be described. Each of the production processes may also be carried out with reference to the References appended in the present description. Further, the preparation methods of the compound of the formula (I) are not limited to the examples as shown below. 
     (Production Process 1) 
     
       
         
         
             
             
         
       
     
     (wherein —CO 2 R represents an ester group such as an alkyl ester, a benzyl ester, and the like (for example, methoxycarbonyl, ethoxycarbonyl, tert-butoxycarbonyl, benzyloxycarbonyl, and the like). 
     The present production process is a method for preparing a compound (I-a) that is the compound of the present invention by hydrolyzing the compound 1a. 
     The hydrolysis reaction can be carried out with reference to “Greene&#39;s Protective Groups in Organic Synthesis (4 th  Ed, 2006)” as described above. 
     (Production Process 2) 
     
       
         
         
             
             
         
       
     
     (wherein Z 1  represents —CONH 2  or a biological equivalent of —CO 2 H). 
     The present production process is a step in which a carboxyl group of a compound (I-a) that is the compound of the present invention prepared by Production Process 1 is converted to a biological equivalent of a carboxamide or carboxylic group. 
     For example, in the case where Z 1  is —CO—NH—SO 2 —C 1-6  alkyl or —CO—NH—SO 2 —N(C 1-6  alkyl) 2 , the compound can be prepared by a condensation reaction with a corresponding sulfonamide or the like, and for example, in the case where Z 1  is —CONH 2 , the compound can be prepared by a condensation reaction using ammonium chloride, ammonium hydroxide, an aqueous ammonia solution, or the like. Further, for example, in the case where Z 1  is tetrazolyl, carboxamide is induced, followed by dehydration by an ordinary method to induce a nitrile, which is reacted with sodium azide, thereby preparing the compound. In addition, a carboxyl group can be converted to a biological equivalent thereof by a method apparent to a person skilled in the art. 
     (Starting Material Synthesis 1) 
     
       
         
         
             
             
         
       
     
     (wherein A 1  represents aryl, cycloalkyl, an aromatic heterocycle, or a non-aromatic heterocycle, each of which may be substituted). 
     The present production process is a method for preparing a compound 2c, in which A is aryl, cycloalkyl, an aromatic heterocycle, or a non-aromatic heterocycle, among the compounds 1a that are the starting compounds of Production Process 1. 
     (First Step) 
     The present step is a step in which ethylenediamine is added to the compound 2a prepared by the method described in Pamphlet of International Publication WO 2007/115935 or a method in accordance therewith. A compound 2b can be prepared by, for example, condensing ethylenediamine having one amino group protected with the compound 2a, and removing the protecting group of the amino group. 
     The condensation reaction can be carried out using the compound 2a and ethylenediamine having one amino group protected in equivalent amounts or with either thereof in an excess amount, and stirring them under any temperature condition from cooling to heating, preferably at −20° C. to 60° C., usually for 0.1 hours to 5 days, in a solvent which is inert to the reaction, in the presence of a condensing agent. The solvent as used herein is not particularly limited, but examples thereof include aromatic hydrocarbons such as benzene, toluene, xylene, and the like, halogenated hydrocarbons such as dichloromethane, 1,2-dichloroethane, chloroform, and the like, ethers such as diethyl ether, tetrahydrofuran (THF), dioxane, dimethoxyethane, and the like, N,N-dimethylformamide (DMF), dimethylsulfoxide (DMSO), ethyl acetate, acetonitrile, water, or a mixture thereof. Examples of the condensing agent include 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide, dicyclohexylcarbodiimide, 1,1′-carbonyldiimidazole, diphenylphosphoryl azide, phosphorus oxychloride, and the like, but are not limited thereto. It may be preferable in some cases for the reaction to use an additive such as 1-hydroxybenzotriazole and the like. It may be preferable in some cases for the progress of the reaction to use an organic base such as triethylamine, N,N-diisopropylethylamine, N-methylmorpholine, and the like, or an inorganic base such as potassium carbonate, sodium carbonate, potassium hydroxide, and the like. 
     The reaction for removing the protecting group of an amino group can be carried out with reference to “Greene&#39;s Protective Groups in Organic Synthesis (4 th  Ed., 2006)” as described above. 
     (Second Step) 
     The present step is a step for acylating the compound 2b. 
     Acylation can be carried out using the compound 2b and a corresponding carboxylic acid (A 1 -CO 2 H), by employing the method of the preceding paragraph of First Step in the present Production Process, or alternatively by converting the corresponding carboxylic acid to a reactive derivative, and then reacting the reactive derivative with the compound 2b. Examples of the reactive derivative of the carboxylic acid include acid halides obtained by the reaction with a halogenating agent such as phosphorus oxychloride, thionyl chloride, and the like, mixed acid anhydrides obtained by the reaction with isobutyl chloroformate or the like, active esters obtained by condensation with 1-hydroxybenzotriazole or the like, and others. The reaction of the reactive derivative and the compound 2b can be carried out by stirring them under any temperature condition from cooling to heating, preferably at −20° C. to 60° C., usually for 0.1 hours to 5 days, in a solvent which is inert to the reaction. The solvent as used herein is not particularly limited, but examples thereof include halogenated hydrocarbons, ethers, aromatic hydrocarbons, or a mixture thereof. 
     (Starting Material Synthesis 2) 
     
       
         
         
             
             
         
       
     
     The present Production Process is a process for preparing a compound 3a in which A is a group represented by the formula (II), among the compounds 1a that are starting compounds of Production Process 1. 
     The present Production Process is a process for preparing a compound 3c by adding an aminocarbonyl group to the compound 2b. 
     In the case of using an amine (HN(—R 11 )(—R 12 )), 1,1′-carbonyldiimidazole, phosgene, triphosgene, or the like can be used as a carbonyl source. This reaction can be carried out using the compound 2b, the corresponding amine, and the carbonyl source in equivalent amounts or with any one thereof in an excess amount, and stirring the mixture under any temperature condition from cooling to heating, preferably under any temperature condition from room temperature to refluxing, usually for 0.1 hours to 5 days, in a solvent which is inert to the reaction. The solvent as used herein is not particularly limited, but examples thereof include ethers, halogenated hydrocarbons, N,N-dimethylformamide, N,N-dimethylacetamide, dimethylsulfoxide, or a mixture thereof. It may be preferable for the progress of the reaction to use a base such as triethylamine, N,N-diisopropylethylamine, N-methylmorpholine, pyridine, and the like. 
     Furthermore, in the case where one of —R 11  and —R 12  is —H (for example, a case where —R 12  is —H), a corresponding isocyanate (R 11 —N═C═O) can be used, and in this case, the reaction can be carried out using the compound 2b and a corresponding isocyanate in equivalent amounts or with either thereof in an excess amount, and stirring the mixture under any temperature condition from cooling to heating, preferably under any temperature condition from heating to refluxing, usually for 0.1 hours to 5 days, in a solvent which is inert to the reaction. The solvent as used herein is not particularly limited, but examples thereof include ethers, halogenated hydrocarbons, N,N-dimethylformamide, N,N-dimethylacetamide, dimethylsulfoxide, or a mixture thereof. Further, the isocyanate can also be produced by, for example, by Curtius rearrangement using the corresponding carboxylic acid and diphenylphosphoryl azide, and then used. 
     (Starting Material Synthesis 3) 
     
       
         
         
             
             
         
       
     
     The present Production Process is a process for preparing compound 4e, in which W is —O—, among the compounds 1a that are the starting compounds of Production Process 1. 
     (First Step) 
     The present step is a step in which the compound 4a prepared in accordance with the method described in Journal of Medicinal Chemistry, 1993, Vol. 36, No. 24, pp. 3968-3970, or a method equivalent thereto is condensed with the compound 4b. 
     The condensation reaction can be carried out using the method described in First Step of the preceding paragraph or the method described in Second Step in Starting Material Synthesis 1. 
     (Second Step) 
     The present step is a step in which the compound 4c and the compound 4d are condensed. 
     For the condensation reaction, a Mitsunobu reaction that is usually employed by a person skilled in the art can be used. The Mitsunobu reaction can be carried out using the compound 4c and the compound 4d in equivalent amounts or with either thereof in an excess amount, using a mixture thereof and an activating agent prepared from a phosphorous compound such as tributylphosphine, triphenylphosphine, and the like and an azodicarbonyl compound such as ethyl azodicarboxylate, 1,1′-(azodicarbonyl)dipiperidine, and the like, or a reagent such as cyanomethylenebutylphosphorane and the like, under any temperature condition from cooling to heating, preferably under any temperature condition from heating to heating, usually for 0.1 hours to 5 days, in a solvent which is inert to the reaction. The solvent as used herein is not particularly limited, but examples thereof include halogenated hydrocarbons, ethers, aromatic hydrocarbons, or a mixture thereof. 
     Furthermore, when carrying out the present step, an alkylation reaction may be employed. When carrying out the alkylation reaction, the reaction can be carried out by converting a hydroxyl group of the compound 4c or the compound 4d to a leaving group, for example, halogen such as chlorine, bromine, iodine, and the like, or sulfonyloxy such as methanesulfonyloxy, ethanesulfonyloxy, benzenesulfonyloxy, 4-methylbenzenesulfonyloxy, trifluoromethanesulfonyloxy, and the like, and stirring them under any temperature condition from cooling to heating, preferably under any temperature condition from room temperature to heating, usually for 0.1 hours to 5 days, in the presence of a suitable base, in a solvent which is inert to the reaction. 
     The compounds of the formula (I) can be isolated and purified as their free compounds, salts, hydrates, solvates, or polymorphic crystalline forms thereof. The salts of the compound of the formula (I) can be prepared by carrying out the treatment of a conventional salt forming reaction. 
     Isolation and purification are carried out by employing ordinary chemical operations such as extraction, fractional crystallization, various types of fractional chromatography, and the like. 
     Various isomers can be prepared by selecting an appropriate starting compound or separated by using the difference in the physicochemical properties between the isomers. For example, the optical isomers can be obtained by means of a general method for designing optical resolution of racemic products (for example, fractional crystallization for inducing diastereomer salts with optically active bases or acids, chromatography using a chiral column or the like, and others), and further, the isomers can also be prepared from an appropriate optically active starting compound. 
     The pharmacological activity of the compound of the formula (I) was confirmed by the tests shown below. 
     Test Example 1 
     DGAT1 Inhibitory Activity Test 
     (1) Production of Bacmid-hDGAT1 
     A base sequence encoding a human DGAT1 (hDGAT1) (1467 bases of CDS in Genbank Accession No. NM — 012079) was cloned and ligated to pFastBac™1 (Invitrogen) to produce a pFastBac1-hDGAT1. From this plasmid, an engineered baculovirus liquid (Bacmid-hDGAT1) was prepared using a Bac-to-Bac (registered trademark) Baculovirus Expression System (Invitrogen). 
     (2) Preparation of Sf9 Cell-Derived DGAT1-Expressing Microsomal Fraction 
     Sf9 cells were seeded into a 225-cm 2  Flask Angled Neck (CORNING) to a confluency of 80%, and statically cultured in an incubator at 27° C. using an EX-CELL™ 420 INSECT SERUM-FREE MEDIUM (SAFC Biosciences, Inc.). After 24 hours, the culture medium was taken out, and a liquid obtained by diluting 1.67 mL of an engineered baculovirus medium (Bacmid-hDGAT1) with 3.33 mL of an EX-CELL™ 420 INSECT SERUM-FREE MEDIUM was added thereto, and the resultant was cultured under shaking in an incubator at 27° C. for 1 hour. Thereafter, 25 mL of an EX-CELL™ 420 INSECT SERUM-FREE MEDIUM was added thereto, followed by culturing in an incubator at 27° C. for 72 hours. The infected cells were harvested, diluted with 1.5 mL of a buffer A (40 mM phosphate buffer (pH 7.2) including 100 mM sucrose and 50 mM KCl) containing a Complete Protease Inhibitor Cocktail (Roche Diagnostics K. K.), and then subjected to sonication using a SONIFER 250 (BRANSON Ultrasonic Corp.). This suspension was centrifuged at 10000×g for 5 minutes and the supernatant was recovered. This supernatant was centrifuged at 100000×g for 60 minutes and the resulting precipitate was dissolved in 600 μL of a buffer A and then subjected to sonication again, to prepare a suspension. This suspension was taken as a hDGAT1-expressing Sf9 cell microsome. 
     (3) DGAT1 Activity Measurement 
     For the DGAT1 activity, a test substance in DMSO (final DMSO concentration 2%) in which 100 mM Tris-HCl (pH 8.0), 2 mM MgCl 2 , 0.01% BSA, a hDGAT1-expressing Sf9 cell microsome, 200 μM dioleoyl glycerol or dipalmitoyl glycerol, 8.9 μM [ 14 C] oleoyl-CoA, and 1.68% acetone were added to a phospholipid FlashPlate (PerkinElmer Life Science). The reaction was carried out at 30° C. for 60 minutes, and then twice the amount (100 μL), relative to the reaction liquid, of a mixture of isopropyl alcohol:0.1 M carbonate buffer (pH 9.0) at a ratio of 1:1 was added thereto to stop the reaction. The next day, the count was measured with a TopCount microplate scintillation counter (PerkinElmer Life Science). 
     The count without addition of the test substance was taken as a control (TG with addition of DMSO). The count without addition of the test substance and the microsome was taken as a Blank TG. The DGAT1 inhibitory rate of the test substance was calculated by the following calculation equation: 
       Inhibitory Rate (%)=(TG with addition of test substance−Blank TG)÷(TG with addition of DMSO−Blank TG)×100
 
     The DGAT1 inhibitory rates were calculated when the concentrations of the test substance in the reaction liquid were 1, 10, 100, and 1000 nM. Linear regression was performed using the inhibitory rates obtained, and a test substance concentration (IC 50 ) required to inhibit the DGAT1 activity by 50% was calculated by an SAS 8.2 software package (SAS Institute Japan, Ltd., Tokyo, Japan). 
     As a result, some of the compounds of the formula (I) showed a DGAT1 inhibitory action at an IC 50  value of 50 nM or less in the above test. The results of the present test of some of the compounds of the formula (I) are shown in Table 1. 
     
       
         
           
               
               
               
             
               
                   
                 TABLE 1 
               
               
                   
                   
               
               
                   
                 Example  
                 IC 50 / 
               
               
                   
                 No. 
                 nM 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                 6 
                 20 
               
               
                   
                 18 
                 21 
               
               
                   
                 20 
                 2.1 
               
               
                   
                 56 
                 14 
               
               
                   
                 63 
                 0.4 
               
               
                   
                 79 
                 2.3 
               
               
                   
                 82 
                 9.9 
               
               
                   
                 83 
                 5.2 
               
               
                   
                 106 
                 5.3 
               
               
                   
                 135 
                 5.8 
               
               
                   
                 148 
                 4.2 
               
               
                   
                 169 
                 2.7 
               
               
                   
                 187 
                 8.1 
               
               
                   
                 245 
                 14 
               
               
                   
                 299 
                 6.7 
               
               
                   
                 300 
                 5.6 
               
               
                   
                 454 
                 1.0 
               
               
                   
                 469 
                 1.7 
               
               
                   
                 480 
                 5.2 
               
               
                   
                 490 
                 3.8 
               
               
                   
                 531 
                 0.1 
               
               
                   
                 571 
                 1.6 
               
               
                   
                 604 
                 32 
               
               
                   
                   
               
            
           
         
       
     
     Test Example 2 
     Inhibitory Action on Increase in Triglyceride (TG) by Fat Administration 
     8- to 15-week male C57BL/6J mice were fasted for four hours, and the test substances were administered to the mice. The test substance was administered after suspending it in a 0.5% methyl cellulose solution. After 20 hours, fat (intralipid 20%, Terumo (Fresenius), 10 mL/kg) was orally administered thereto. Immediately before and after 2 hours from administration of the fat, blood was collected from the tail vein to obtain plasma. For measurement of the TG in plasma, a TG increase in the plasma by fat administration was calculated using a Triglyceride E Test Wako (Wako Pure Chemical Industries Ltd.). Using the TG increase in the plasma in a group to which 0.5% methyl cellulose had been administered as a control, the TG increase inhibitory rate when the test substance had been administered was determined. 
     As a result, among the Example Compounds below, the compound of Example 79 showed a TG increase inhibitory rate of 79% with an administration amount of 0.3 mg/kg, the compound of Example 169 showed a TG increase inhibitory rate of 75% with an administration amount of 0.3 mg/kg, the compound of Example 454 showed a TG increase inhibitory rate of 106% with an administration amount of 0.3 mg/kg, the compound of Example 469 showed a TG increase inhibitory rate of 109% with an administration amount of 0.3 mg/kg, and the compound of Example 490 showed a TG increase inhibitory rate of 92% with an administration amount of 0.3 mg/kg. 
     Test Example 3 
     Anti-Obesity Action in DIO Mice 
     High-fat diet formula (Research Diet D12492, 60 kcal % fat) were given to 9-week male C57BL/6J mice. For acclimatization of the mice, the solvent used in the test from the 4 th  week was administered thereto. From the 5 th  week, the test substance was orally administered once or twice daily. The test substance was administered after suspending it in a 0.5% methyl cellulose solution. Administration was performed repeatedly for 2 or 4 weeks, and variation in the weights due to the test substance administration was observed. By taking the increase in the weight in the group to which the solvent had been administered within a test period as 100%, the weight increase inhibitory rate of the test substance was calculated. 
     As a result, among the Example Compounds below, the compound of Example 454 showed a weight increase inhibitory rate of 93% with an administration of once per day, an administration period of 2 weeks, and an administration amount of 1 mg/kg, and the compound of Example 490 showed a weight increase inhibitory rate of 98% with an administration of once per day, an administration period of 2 weeks, and an administration amount of 1 mg/kg. 
     As a result of the tests above, it was confirmed that the compound of the formula (I) has an anti-obesity action in a diet-induced obesity model, and can be therefore used for preventing and/or treating obesity, type II diabetes mellitus, fatty liver, or the like. 
     A pharmaceutical composition containing one or two or more kinds of the compound of the formula (I) or a salt thereof as an active ingredient can be prepared using excipients that are usually used in the art, that is, excipients for pharmaceutical preparation, carriers for pharmaceutical preparation, and the like according to the methods usually used. 
     Administration can be accomplished either by oral administration via tablets, pills, capsules, granules, powders, solutions, and the like, or parenteral administration injections, such as intraarticular, intravenous, or intramuscular injections, and the like, suppositories, ophthalmic solutions, eye ointments, transdermal liquid preparations, ointments, transdermal patches, transmucosal liquid preparations, transmucosal patches, inhalers, and the like. 
     The solid composition for use in the oral administration according to the present invention is used in the form of tablets, powders, granules, or the like. In such a solid composition, one or more active ingredient(s) are mixed with at least one inactive excipient, such as lactose, mannitol, glucose, hydroxypropyl cellulose, microcrystalline cellulose, starch, polyvinylpyrrolidone, and/or magnesium aluminometasilicate. In a conventional method, the composition may contain inactive additives, such as a lubricant such as magnesium stearate, a disintegrating agent such as sodium carboxymethyl starch and the like, a stabilizer, or a solubilization assisting agent. If necessary, tablets or pills may be coated with sugar or a film of a gastric or enteric coating substance. 
     The liquid composition for oral administration contains pharmaceutically acceptable emulsions, solutions, suspensions, syrups, elixirs, or the like, and also contains generally used inert diluents, for example, purified water or ethanol. In addition to the inert diluent, the liquid composition may also contain auxiliary agents, such as a solubilization assisting agent, a moistening agent, and a suspending agent, sweeteners, flavors, aromatics, and antiseptics. 
     The injections for parenteral administration include sterile aqueous or non-aqueous solution preparations, suspensions and emulsions. The aqueous solvent includes, for example, distilled water for injection and physiological saline. Examples of the non-aqueous solvent include palcohols such as ethanol. Such a composition may further contain a tonicity agent, an antiseptic, a moistening agent, an emulsifying agent, a dispersing agent, a stabilizing agent, or a solubilizing aid. These are sterilized, for example, by filtration through a bacteria retaining filter, blending of a bactericide, or irradiation. In addition, these can also be used by preparing a sterile solid composition, and dissolving or suspending it in sterile water or a sterile solvent for injection prior to its use. 
     The agent for external use includes ointments, plasters, creams, jellies, patches, sprays, lotions, eye drops, eye ointments, and the like. The agents contain generally used ointment bases, lotion bases, aqueous or non-aqueous liquid preparations, suspensions, emulsions, and the like. 
     As the transmucosal agents such as an inhaler, a transnasal agent, and the like, those in the form of a solid, liquid, or semi-solid state are used, and can be prepared in accordance with a conventionally known method. For example, a known excipient, and also a pH adjusting agent, an antiseptic, a surfactant, a lubricant, a stabilizing agent, a thickening agent, or the like may be appropriately added thereto. For their administration, an appropriate device for inhalation or blowing can be used. For example, a compound may be administered alone or as a powder of formulated mixture, or as a solution or suspension in combination with a pharmaceutically acceptable carrier, using a conventionally known device or sprayer, such as a measured administration inhalation device, and the like. A dry powder inhaler or the like may be for single or multiple administration use, and a dry powder or a powder-containing capsule may be used. Alternatively, this may be in a form such as a pressurized aerosol spray which uses an appropriate ejection agent, for example, a suitable gas such as chlorofluoroalkane, hydrofluoroalkane, carbon dioxide, and the like, or other forms. 
     In oral administration, the daily dose is generally from about 0.001 to 100 mg/kg, preferably from 0.1 to 30 mg/kg, and more preferably 0.1 to 10 mg/kg, per body weight, administered in one portion or in 2 to 4 divided portions. In the case of intravenous administration, the daily dose is suitably administered from about 0.0001 to 10 mg/kg per body weight, once a day or two or more times a day. In addition, a transmucosal agent is administered at a dose from about 0.001 to 100 mg/kg per body weight, once a day or two or more times a day. The dose is appropriately decided in response to the individual case by taking the symptoms, the age, and the gender, and the like into consideration. 
     Although varying depending on administration routes, dosage forms, administration sites, or the types of excipients and additives, the pharmaceutical composition of the present invention contains 0.01 to 100% by weight, and in a certain embodiment, 0.01 to 50% by weight of one or more kinds of the compound of the formula (I) or a salt thereof, which is an active ingredient. 
     The compound of the formula (I) can be used in combination with various agents for treating or preventing the diseases, in which the compound of the formula (I) is considered effective, as described above. The combined preparation may be administered simultaneously or separately and continuously, or at a desired time interval. The preparations to be co-administered may be prepared individually or may be a pharmaceutical composition including various agents for treating or preventing the diseases, in which the compound of the formula (I) is considered effective, as described above, and the compound of the formula (I). 
     EXAMPLES 
     Hereinbelow, the preparation methods for the compound of the formula (I) will be described in more detail with reference to Examples. Further, the present invention is not limited to the compounds described in the Examples as described below. Furthermore, the production processes for the starting compounds will be described in Preparation Examples. Further, the preparation methods for the compound of the formula (I) are not limited to the preparation methods of the specific Examples as below, but the compound of the formula (I) can be prepared by any combination of the preparation methods or the methods that are apparent to a person skilled in the art. 
     Furthermore, the following abbreviations may be used in some cases in Examples, Preparation Examples, and Tables below. 
     Pr: Preparation Example No. (in which the Preparation Example Compound having “/Cl” described after the Preparation Example No. denotes that the Preparation Example Compound was isolated as hydrochloride, and the Preparation Example Compound having “/TF” described after the Preparation Example No. denotes that the Preparation Example Compound was isolated as trifluoroacetate. Further, the compound in which “*” is attached to the Preparation Example No. denotes that the compound is an optically active form), Ex: Example No. (in which the compound in which “*” is attached to the Example No. denotes that the compound is an optically active form), No: Compound No., Structure: Chemical Structural Formula (Me: methyl, Et: ethyl, iPr: isopropyl, tBu: tert-butyl, nPen: normal pentyl, Ph: phenyl, and Bn: benzyl), Syn: Preparation method (the numeral shows that this compound was prepared by the same preparation method as the compound having the Example No. described in this section), PSy: Preparation method (the numeral shows that this compound was prepared by the same preparation method as the compound having the Preparation Example No. described in this section), Data: Physical data (which show the data of the compound as follows. EI: EI-MS; ESP: ESI-MS (Pos); ESN: ESI-MS (Neg); FP: FAB-MS (Pos); FN: FAB-MS (Neg); NMR1: δ (ppm) of the characteristic peak in  1 H-NMR in DMSO-d 6 ; NMR2: δ (ppm) of the characteristic peak in  1 H-NMR in CDCl 3 ). 
     Preparation Example 1 
     To a mixture of ethyl trans-4-hydroxycyclohexanecarboxylate (8 g), benzyl 4-hydroxybenzoate (11.69 g), 1,1′-(azodicarbonyl)dipiperidine (15.24 g), and THF (150 ml) was added dropwise tributylphosphine (14.9 ml) under ice-cooling, followed by stirring at room temperature for 2 hours, and then stirring at 60° C. for 10 hours. The reaction mixture was returned to room temperature, then filtered, and washed with THF, and then the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate=85:15) to obtain 8.55 g of benzyl 4-{[cis-4-(ethoxycarbonyl)cyclohexyl]oxy}benzoate as a colorless oil. 
     Preparation Example 2 
     To a mixture of benzyl 4-{[cis-4-(ethoxycarbonyl)cyclohexyl]oxy}benzoate (8.5 g) and EtOH (150 ml) was added 10% palladium on activated carbon (850 mg), followed by stirring at room temperature for 4 hours under a hydrogen atmosphere (balloon pressure). The reaction mixture was filtered through Celite and washed with EtOH, and then the resulting filtrate was concentrated under reduced pressure to obtain 5.8 g of 4-{[cis-4-(ethoxycarbonyl)cyclohexyl]oxy}benzoic acid as a colorless solid. 
     Preparation Example 3 
     To a mixture of 4-{[cis-4-(ethoxycarbonyl)cyclohexyl]oxy}benzoic acid (4 g), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride (3.4 g), 1-hydroxybenzotriazole monohydrate (2.7 g), triethylamine (2.9 ml), and DMF (60 ml) was added tert-butyl (2-aminoethyl)carbamate (2.6 ml), followed by stirring at room temperature for 14 hours. To the reaction mixture was added water, and the precipitated solid was collected by filtration and then washed with diisopropyl ether to obtain 5.34 g of ethyl cis-4-[4-({2-[(tert-butoxycarbonyl)amino]ethyl}carbamoyl)phenoxy]cyclohexanecarboxylate as a colorless solid. 
     Preparation Example 4 
     To a mixture of ethyl cis-4-[4-({2-[(tert-butoxycarbonyl)amino]ethyl}carbamoyl)phenoxy]cyclohexanecarboxylate (5.34 g) and dioxane (80 ml) was added 4 M hydrogen chloride/dioxane (40 ml), followed by stirring at room temperature for 3 hours. The reaction mixture was concentrated under reduced pressure and the residue was washed with diisopropyl ether to obtain 4.55 g of ethyl cis-4-{4-[(2-aminoethyl)carbamoyl]phenoxy}cyclohexanecarboxylate hydrochloride as a colorless solid. 
     Preparation Example 5 
     To a mixture of ethyl 4-{4-[(2-aminoethyl)carbamoyl]phenoxy}cyclohexanecarboxylate hydrochloride (150 mg), chloroform (5 ml), and triethylamine (0.17 ml) was added phenyl isocyanate (0.053 ml), followed by stirring at room temperature for 1 hour. To the reaction mixture was added a saturated aqueous sodium hydrogen carbonate solution, followed by carrying out a separation of the layers, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:methanol (MeOH)=90:10) to obtain 164 mg of ethyl 4-[4-({2-[(anilinocarbonyl)amino]ethyl}carbamoyl)phenoxy]cyclohexanecarboxylate as a colorless solid. 
     Preparation Example 6 
     To a mixture of ethyl cis-4-{4-[(2-aminoethyl)carbamoyl]phenoxy}cyclohexanecarboxylate hydrochloride (200 mg), triethylamine (0.08 ml), and methylene chloride (10 ml) was added carbonyldiimidazole (100 mg) at 0° C., followed by stirring at 0° C. for 10 minutes, and then 4-phenylpiperidine (110 mg) was added thereto, followed by stirring at room temperature for 3 days. To the reaction mixture was added water, followed by carrying out a separation of the layers using chloroform, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:MeOH=100:0 to 95:5) to obtain 288 mg of ethyl cis-4-{4-[(2-{[(4-phenylpiperidin-1-yl)carbonyl]amino}ethyl)carbamoyl]phenoxy}cyclohexanecarboxylate as a colorless solid. 
     Preparation Example 7 
     A mixture of ethyl 4-{4-[(2-aminoethyl)carbamoyl]phenoxy}cyclohexanecarboxylate hydrochloride (100 mg), 4-phenylcyclohexanecarboxylic acid (66 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride (67 mg), 1-hydroxybenzotriazole monohydrate (54 mg), and THF (1.5 ml) was stirred at room temperature for 9 hours. To the reaction mixture was added a saturated aqueous sodium hydrogen carbonate solution, followed by carrying out a separation of the layers using chloroform, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform) to obtain 123 mg of ethyl 4-{4-[(2-{[(4-phenylcyclohexyl)carbonyl]amino}ethyl)carbamoyl]phenoxy}cyclohexanecarboxylate as a colorless solid. 
     Preparation Example 8 
     To a mixture of ethyl trans-4-{4-[(2-aminoethyl)carbamoyl]phenoxy}cyclohexanecarboxylate hydrochloride (100 mg), chloroform (10 ml), and triethylamine (0.14 ml) was added benzoyl chloride (0.038 ml) at 0° C., followed by stirring at 0° C. for 1 hour. The reaction mixture was added to a saturated aqueous sodium hydrogen carbonate solution, followed by carrying out a separation of the layers using chloroform, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was washed with diisopropylether to obtain 118 mg of ethyl trans-4-(4-({[2-(benzoylamino)ethyl]carbamoyl}phenoxy)cyclohexanecarboxylate as a colorless solid. 
     Preparation Example 9 
     A mixture of N-(2-aminoethyl)-4-chlorobenzamide hydrochloride (400 mg), 2-fluoro-4-hydroxybenzoic acid (320 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride (500 mg), 1-hydroxybenzotriazole monohydrate (400 mg), triethylamine (0.4 ml), and DMF (10 ml) was stirred at room temperature overnight. To the reaction mixture was added water, followed by carrying out a separation of the layers using chloroform, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:MeOH=100:0 to 95:5) to obtain 410 mg of N-{2-[(4-chlorobenzoyl)amino]ethyl}-2-fluoro-4-hydroxybenzamide as a colorless solid. 
     Preparation Example 10 
     To a mixture of N-{2-[(4-chlorobenzoyl)amino]ethyl}-2-fluoro-4-hydroxybenzamide (400 mg), ethyl trans-4-hydroxycyclohexanecarboxylate (220 mg), triphenylphosphine (350 mg), and THF (4 ml) was added a 2.2 M diethyl azodicarboxylate solution in toluene (0.58 ml) at room temperature, followed by stirring at 60° C. overnight. To the reaction mixture was added water, followed by carrying out a separation of the layers using ethyl acetate, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:MeOH=100:0 to 95:5) to obtain 457 mg of ethyl cis-4-[4-({2-[(4-chlorobenzoyl)amino]ethyl}carbamoyl)-3-fluorophenoxy]cyclohexanecarboxylate as a colorless solid. 
     Preparation Example 11 
     To a mixture of ethyl cis-4-hydroxycyclohexanecarboxylate (800 mg), triphenylphosphine (1.34 g), THF (15 ml), and 4-fluorophenol (521 mg) was added dropwise a 2.2 M diethyl azodicarboxylate solution in toluene (2.3 ml) over 10 minutes under ice-cooling, followed by stirring at 60° C. for 4 hours. The reaction mixture was added to a saturated aqueous sodium hydrogen carbonate solution, followed by carrying out a separation of the layers using ethyl acetate. Thereafter, the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was crudely purified by silica gel column chromatography (hexane:ethyl acetate=85:15). To a mixture of the crude product (685 mg), THF (5 ml), and EtOH (5 ml) was added a 1 M aqueous sodium hydroxide solution, followed by stirring at room temperature for 14 hours. The solvent was evaporated under reduced pressure, and then to the residue was added water, followed by carrying out a separation of the layers using ethyl acetate. Then, the aqueous layer was adjusted to pH 3 by the addition of 1 M hydrochloric acid, followed by carrying out a separation of the layers using ethyl acetate. The organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure to obtain 242 mg of trans-4-(4-fluorophenoxy)cyclohexanecarboxylic acid as a colorless solid. 
     Preparation Example 12 
     A mixture of 3-fluoro-4-hydroxybenzoic acid (5 g), benzyl bromide (4.19 ml), DMF (33 ml), and potassium carbonate (4.9 g) was stirred at 40° C. for 6 hours. The reaction mixture was left to stand for cooling, then diluted with ethyl acetate, washed with water, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:ethyl acetate=100:0 to 50:50) to obtain 1.7 g of benzyl 3-fluoro-4-hydroxybenzoate as a colorless solid. 
     Preparation Example 13 
     To a mixture of 4-[(cis-4-carbamoylcyclohexyl)oxy]-N-{2-[(4-chlorobenzoyl)amino]ethyl}benzamide (330 mg) and THF (20 ml) was added anhydrous trifluoroacetic acid (0.29 ml), followed by stirring at room temperature for 30 minutes, and then anhydrous trifluoroacetic acid (0.07 ml) was added thereto, followed by stirring for 10 minutes. To the reaction mixture was added a saturated aqueous sodium hydrogen carbonate solution, followed by carrying out a separation of the layers using ethyl acetate. Thereafter, the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. To the resulting residue were added diisopropylether and EtOH, and then the solid was collected by filtration and washed with EtOH to obtain 168 mg of 4-chloro-N-[2-({4-[(cis-4-cyanocyclohexyl)oxy]benzoyl}amino)ethyl]benzamide as a colorless solid. 
     Preparation Example 14 
     To a mixture of methyl 4-(4-oxocyclohexyl)benzoate (1.3 g) and toluene (10 ml) was added (tert-butoxycarbonylmethylene)triphenylphosphorane (2.5 g), followed by stirring at 105° C. for 24 hours. To the reaction mixture were added ethyl acetate and water, followed by carrying out a separation of the layers, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=100:0 to 90:10) to obtain 1.35 g of methyl 4-[4-(2-tert-butoxy-2-oxoethylidene)cyclohexyl]benzoate as a colorless solid. 
     Preparation Example 15 
     To a mixture of methyl 4-[4-(2-tert-butoxy-2-oxoethylidene)cyclohexyl]benzoate (1.3 g), MeOH (20 ml), and THF (6 ml) was added 10% palladium on activated carbon (130 mg), followed by stirring at room temperature for 4 hours under a hydrogen atmosphere (3 atm). The reaction mixture was filtered through Celite and washed with MeOH, and then the resulting filtrate was concentrated under reduced pressure to obtain 1.11 g of {4-[4-(methoxycarbonyl)phenyl]cyclohexyl}acetic acid as a colorless solid. 
     Preparation Example 16 
     To a mixture of {4-[4-(methoxycarbonyl)phenyl]cyclohexyl}acetic acid (1.1 g) and methylene chloride (15 ml) was added oxalic chloride (0.7 ml) at 0° C., followed by stirring at room temperature for 3 hours. This reaction mixture was concentrated under reduced pressure, and then tert-butanol (15 ml) and diisopropylethylamine (1.4 ml) were added thereto, followed by stirring at room temperature overnight. The reaction mixture was concentrated under reduced pressure and diluted with ethyl acetate, and then this mixture was washed sequentially with a saturated aqueous sodium hydrogen carbonate solution and a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=100:0 to 80:20) to obtain 1.14 g of methyl 4-[4-(2-tert-butoxy-2-oxoethyl)cyclohexyl]benzoate as a colorless solid. 
     Preparation Example 17 
     To a mixture of methyl 4-[4-(2-tert-butoxy-2-oxoethyl)cyclohexyl]benzoate (1.1 g), THF (11 ml), and MeOH (11 ml) was added a 1 M aqueous sodium hydroxide solution (5 ml) at room temperature, followed by stirring at room temperature for 5 hours and then at 50° C. for 1 hour. The reaction mixture was returned to room temperature, and then concentrated under reduced pressure. Water was added, and then a 10% aqueous citric acid solution was added thereto until the pH became 5. The precipitated solid was collected by filtration to obtain 835 mg of 4-[4-(2-tert-butoxy-2-oxoethyl)cyclohexyl]benzoic acid as a colorless solid. 
     Preparation Example 18 
     A mixture of ethyl 3-chloro-4-hydroxybenzoate (2 g), potassium iodide (165 mg), bromomethylcyclobutane (1.7 ml), potassium carbonate (2.8 g), and DMF (50 ml) was stirred at 60° C. for 5 hours. The reaction mixture was left to stand for cooling, then diluted with ethyl acetate, washed sequentially with water and a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to obtain an oil. To a mixture of this oil, THF (20 ml), and MeOH (20 ml) was added a 1 M aqueous sodium hydroxide solution (20 ml), followed by stirring overnight. To the reaction mixture was added 1 M hydrochloric acid (20 ml), followed by concentrating under reduced pressure to remove the organic solvent. The precipitated solid was collected by filtration to obtain 1.31 g of 3-chloro-4-(cyclobutylmethoxy)benzoic acid as a colorless solid. 
     Preparation Example 19 
     A mixture of 4-fluoro-3-hydroxybenzoic acid (2 g), potassium iodide (250 mg), bromomethylcyclopropane (3.7 ml), potassium carbonate (5.3 g), and DMF (27 ml) was stirred at 60° C. overnight. To the reaction mixture was added ethyl acetate, then washed sequentially with water and a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to obtain an oil. To a mixture of this oil, THF (30 ml), and MeOH (30 ml) was added a 1 M aqueous sodium hydroxide solution (30 ml), followed by stirring for 5 hours. To the reaction mixture was added 1 M hydrochloric acid (30 ml), and then concentrated under reduced pressure to remove the organic solvent. The precipitated solid was collected by filtration to obtain 2.55 g of 3-(cyclopropylmethoxy)-4-fluorobenzoic acid as a colorless solid. 
     Preparation Example 20 
     A mixture of ethyl 4-bromo-3-fluorobenzoate (1 g), cyclopropylboronic acid monohydrate (643 mg), tetrakistriphenylphosphinepalladium (235 mg), potassium phosphate (3.1 g), toluene (10 ml), and water (1 ml) was thoroughly stirred at 110° C. overnight. To the reaction mixture was added water, followed by carrying out a separation of the layers using ethyl acetate, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was crudely purified by silica gel column chromatography (hexane:ethyl acetate=85:15), and then to a mixture of the crude product, THF (20 ml), and MeOH (20 ml) was added a 1 M aqueous sodium hydroxide solution (20 ml), followed by stirring at room temperature overnight. To the reaction mixture was added 1 M hydrochloric acid (20 ml), followed by concentrating under reduced pressure to remove the organic solvent. The precipitated solid was collected by filtration to obtain 600 mg of 4-cyclopropyl-3-fluorobenzoic acid as a colorless solid. 
     Preparation Example 21 
     A mixture of ethyl 4-bromo-3-chlorobenzoate (1 g), cyclopropylboronic acid monohydrate (602 mg), tetrakistriphenylphosphinepalladium (220 mg), potassium phosphate (2.8 g), toluene (10 ml), and water (1 ml) was stirred under reflux overnight. To the reaction mixture was added water, followed by carrying out a separation of the layers using ethyl acetate, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=100:0 to 90:10) to obtain 770 mg of ethyl 3-chloro-4-cyclopropylbenzoate as a colorless oil. 
     Preparation Example 22 
     To a mixture of ethyl 3-chloro-4-cyclopropylbenzoate (760 mg), THF (10 ml), and EtOH (10 ml) was added a 1 M aqueous sodium hydroxide solution (10 ml), followed by stirring at room temperature overnight. The reaction mixture was concentrated under reduced pressure, diluted with water, and then adjusted to pH 2 by the addition of 1 M hydrochloric acid (20 ml). The precipitated solid was collected by filtration to obtain 666 mg of 3-chloro-4-cyclopropylbenzoic acid as a colorless solid. 
     Preparation Example 23 
     To a mixture of 3-fluorophenol (400 mg), ethyl cis-4-hydroxycyclohexanecarboxylate (770 mg), triphenylphosphine (1.4 g), and THF (5 ml) was added a 2.2 M diethyl azodicarboxylate solution in toluene (2 ml) under ice-cooling, followed by stirring at room temperature overnight. To the reaction mixture were added ethyl acetate (20 ml) and a saturated aqueous sodium chloride solution (20 ml), followed by carrying out a separation of the layers, and the organic layer was dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. To the residue were added hexane (16 ml) and ethyl acetate (4 ml), and the precipitate was separated by filtration. Then, the resulting filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=100:0 to 93:7) to obtain 357 mg of ethyl trans-4-(3-fluorophenoxy)cyclohexanecarboxylate as a colorless oil. 
     Preparation Example 24 
     To a mixture of ethyl trans-4-(3-fluorophenoxy)cyclohexanecarboxylate (350 mg), THF (4 ml), and EtOH (4 ml) was added a 1 M aqueous sodium hydroxide solution (4 ml), followed by stirring at room temperature overnight. The reaction mixture was concentrated under reduced pressure to remove the organic solvent, and then 1 M hydrochloric acid (5 ml) was added thereto, followed by stirring for a while. The precipitated solid was collected by filtration to obtain 278 mg of trans 4-(3-fluorophenoxy)cyclohexanecarboxylic acid as a colorless solid. 
     Preparation Example 116 
     A mixture of 6-hydroxynicotinic acid (1.5 g), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride (2.5 g), 1-hydroxybenzotriazole monohydrate (2.0 g), triethylamine (2.5 ml), tert-butyl (2-aminoethyl)carbamate (1.8 ml), and DMF (30 ml) was stirred at room temperature overnight. To the reaction mixture was added water, followed by carrying out a separation of the layers using a mixed solvent (3:1) of chloroform and isopropanol, and the organic layer was dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:MeOH=100:0 to 90:10) and the resulting product was solidified by the addition of hexane-ethyl acetate (=1:1), and then the solid was collected by filtration and washed to obtain 1.91 g of tert-butyl (2-{[(6-hydroxypyridin-3-yl)carbonyl]amino}ethyl)carbamate as a colorless solid. 
     Preparation Example 117 
     To a mixture of tert-butyl (2-{[(6-hydroxypyridin-3-yl)carbonyl]amino}ethyl)carbamate (1.9 g), ethyl trans-4-hydroxycyclohexanecarboxylate (1.3 g), triphenylphosphine (2.7 g), and THF (50 ml) was added a 2.2 M diethyl azodicarboxylate solution in toluene (3.7 ml) at 0° C., followed by stirring at room temperature overnight. To the reaction mixture was added water, followed by carrying out a separation of the layers using chloroform, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:MeOH=100:0 to 95:5) to obtain 1.41 g of ethyl cis-4-{[5-({2-[(tert-butoxycarbonyl)amino]ethyl}carbamoyl)pyridin-2-yl]oxy}cyclohexanecarboxylate as a colorless solid. 
     Preparation Example 118 
     A mixture of benzyl 4-{[cis-4-(ethoxycarbonyl)cyclohexyl]oxy}-2-hydroxybenzoate (530 mg), iodomethane (0.4 ml), potassium carbonate (220 mg), and DMF (5 ml) was stirred at room temperature for 3.5 hours, and then stirred at 45° C. for 1 hour. Thereafter, potassium carbonate (175 mg) was added thereto, followed by stirring at room temperature overnight. To the reaction mixture was added water (20 ml), followed by carrying out a separation of the layers using ethyl acetate, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to obtain 605 mg of benzyl 4-{[cis-4-(ethoxycarbonyl)cyclohexyl]oxy}-2-methoxybenzoate as a brownoil. 
     Preparation Example 119 
     A mixture of benzyl 2-chloro-4-{[cis-4-(ethoxycarbonyl)cyclohexyl]oxy}benzoate (500 mg), cyclopropylboronic acid monohydrate (190 mg), tetrakistriphenylphosphinepalladium (70 mg), potassium phosphate (894 mg), toluene (5 ml), and water (0.5 ml) was stirred under reflux overnight. To the reaction mixture was added water, followed by carrying out a separation of the layers using ethyl acetate, and the organic layer was dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=90:10) to obtain 320 mg of benzyl 2-cyclopropyl-4-{[cis-4-(ethoxycarbonyl)cyclohexyl]oxy}benzoate as a colorless oil. 
     Preparation Example 120 
     To a mixture of benzyl 4-fluoro-2-(trifluoromethyl)benzoate (4.1 g), 2-(methylsulfonyl)ethanol (2.53 g), and DMF (50 ml) was added potassium tert-butoxide (4.67 g) under ice-cooling, followed by stirring at room temperature for 3 hours. To the reaction mixture were added 1 M hydrochloric acid and water, followed by carrying out a separation of the layers using ethyl acetate, and the organic layer was washed with water and a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=90:10 to 80:20) to obtain 1.19 g of benzyl 4-hydroxy-2-(trifluoromethyl)benzoate as a pale yellow oil. 
     Preparation Example 121 
     To a mixture of 2-chloro-4-{[cis-4-(ethoxycarbonyl)cyclohexyl]oxy}benzoic acid (1.8 g), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride (1.37 g), 1-hydroxybenzotriazole monohydrate (1.10 g), triethylamine (1.15 ml), and DMF (50 ml) was added tert-butyl (2-aminoethyl)carbamate (0.96 ml), followed by stirring at room temperature overnight. To the reaction mixture was added water (200 ml), and the precipitated solid was collected by filtration. To a mixture of this solid and dioxane (30 ml) was added 4 M hydrogen chloride/dioxane (15 ml), followed by stirring at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure and the residue was washed with a mixed solvent of hexane-diisopropylether to obtain 2.09 g of ethyl cis-4-{4-[(2-aminoethyl)carbamoyl]-3-chlorophenoxy}cyclohexanecarboxylate hydrochloride as a colorless solid. 
     Preparation Example 122 
     To a mixture of methyl [trans-4-(4-hydroxyphenyl)cyclohexyl]acetate (1.25 g), methylene chloride (25 ml), and N-ethyl-N-isopropylpropan-2-amine (1.05 ml) was added trifluoromethanesulfonyl chloride (0.636 ml) at 0° C., followed by stirring at room temperature overnight. To the reaction mixture was added a saturated aqueous sodium hydrogen carbonate solution, followed by carrying out a separation of the layers using chloroform, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=100:0 to 50:50) to obtain 1.38 g of methyl [trans-4-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)cyclohexyl]acetate as a colorless solid. 
     Preparation Example 123 
     A mixture of methyl [trans-4-(4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)cyclohexyl]acetate (200 mg), DMF (10 ml), N-(2-aminoethyl-4-chloro-3-methylbenzamide hydrochloride (200 mg), a 1,1′-bis(diphenylphosphino)ferrocene palladium(II) dichloride/dichloromethane complex (90 mg), and triethylamine (0.2 ml) was stirred at 90° C. for 18 hours under 1 atm of carbon monoxide. The reaction mixture was returned to room temperature, and then water (50 ml) was added thereto. The precipitated solid was collected by filtration. This solid was purified by silica gel column chromatography (chloroform:MeOH=100:0 to 95:5 to 90:10) to obtain 96 mg of methyl {trans-4-[4-({2-[(4-chloro-3-methylbenzoyl)amino]ethyl}carbamoyl)phenyl]cyclohexyl}acetate as a brown solid. 
     Preparation Example 124 
     To a mixture of cis-4-(hydroxymethyl)cyclohexanecarboxylic acid (5 g) and ethanol (50 ml) was added concentrated sulfuric acid (0.3 ml) at room temperature, followed by stirring under reflux for 8 hours. The reaction mixture was returned to room temperature and concentrated under reduced pressure. The residue was added to a saturated aqueous sodium hydrogen carbonate solution, followed by carrying out a separation of the layers using chloroform, and the organic layer was dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to obtain 5.8 g of ethyl cis-4-(hydroxymethyl)cyclohexanecarboxylate as a colorless oil. 
     Preparation Example 125 
     To a mixture of ethyl 1-methyl-4-oxocyclohexanecarboxylate (3 g) and ethanol (30 ml) was added sodium borohydride (616 mg) at 0° C., followed by stirring for 2 hours. To the reaction mixture were added water and ethyl acetate, followed by carrying out a separation of the layers using ethyl acetate, and the organic layer was washed sequentially with a saturated aqueous sodium hydrogen carbonate solution and a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=100:0 to 90:10 to 80:20) to obtain 1.27 g of ethyl cis-4-hydroxy-1-methylcyclohexanecarboxylate as a colorless oil. 
     Preparation Example 126 
     A mixture of ethyl cis-4-[4-({2-[(4-hydroxybenzoyl)amino]ethyl}carbamoyl)phenoxy]cyclohexanecarboxylate (50 mg), DMF (2 ml), potassium carbonate (30 mg), and 2-chlorobenzyl bromide (0.019 ml) was stirred at 60° C. overnight. To the reaction mixture was added water, followed by carrying out a separation of the layers using chloroform, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:MeOH=100:0 to 95:5), and then the precipitated solid was washed with diisopropylether to obtain 53 mg of ethyl cis-4-(4-{[2-({4-[(2-chlorobenzyl)oxy]benzoyl}amino)ethyl]carbamoyl}phenoxy)cyclohexanecarboxylate as a colorless solid. 
     Preparation Example 127 
     A mixture of benzyl 4-fluorobenzoate (1.5 g), DMSO (10 ml), methyl piperidin-4-ylacetate hydrochloride (1.26 g), and potassium carbonate (1.81 mg) was stirred at 100° C. for 20 hours. The reaction mixture was added to water, followed by carrying out a separation of the layers using ethyl acetate, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=80:20) to obtain 1.475 g of benzyl 4-[4-(2-methoxy-2-oxoethyl)piperidin-1-yl]benzoate as a colorless solid. 
     Preparation Example 128 
     To a mixture of tert-butyl 4-{[cis-4-(ethoxycarbonyl)cyclohexyl]oxy}-2,5-difluorobenzoate (4 g) and dioxane (40 ml) was added a 4 M hydrogen chloride solution in dioxane (60 ml), followed by stirring at room temperature for 1 hour and then stirring at 60° C. for 5 hours. The reaction mixture was concentrated under reduced pressure and the residue was washed with diisopropyl ether to obtain 3.36 g of 4-{[cis-4-(ethoxycarbonyl)cyclohexyl]oxy}-2,5-difluorobenzoic acid as a colorless solid. 
     Preparation Example 129 
     To a mixture of tert-butyl 4-(benzyloxy)-2,5-difluorobenzoate (7.47 g) and THF (101 ml) was added 10% palladium on activated carbon (747 mg), followed by stirring at room temperature for 5 hours under a hydrogen atmosphere (balloon pressure). The reaction mixture was filtered through Celite and washed with ethanol, and then the resulting filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:ethyl acetate=98:2 to 50:50) to obtain 4 g of tert-butyl 2,5-difluoro-4-hydroxybenzoate as a colorless solid. 
     Preparation Example 130 
     To a mixture of tert-butyl (2-aminoethyl)carbamate (4.88 ml), triethylamine (4.49 ml), and DMF (100 ml) was added 2-naphthoyl chloride (5.59 g), followed by stirring at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure, then water (200 ml) was added thereto, and the precipitated solid was collected by filtration. To a mixture of this solid and dioxane (200 ml) was added 4 M hydrogen chloride solution in dioxane (100 ml), followed by stirring at room temperature overnight. 
     The reaction mixture was filtered, and the solid was collected by filtration and then washed with diisopropylether to obtain 7.7 g of N-(2-aminoethyl)-2-naphthamide hydrochloride as a colorless solid. 
     Preparation Example 131 
     To a mixture of tert-butyl (2-aminoethyl)carbamate (4.34 ml), triethylamine (4.5 ml), and methylene chloride (50 ml) was added 2-chlorophenyl isocyanate (3.8 g), followed by stirring at room temperature for 2 hours. The reaction mixture was concentrated under reduced pressure, then water (200 ml) was added thereto, and the precipitated solid was collected by filtration. To a mixture of this solid and dioxane (20 ml) was added a 4 M hydrogen chloride solution in dioxane (50 ml), followed by stirring at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure and the residue was washed with diisopropyl ether to obtain 5.89 g of 1-(2-aminoethyl)-3-(2-chlorophenyl)urea hydrochloride as a colorless solid. 
     Preparation Example 132 
     To a mixture of benzyl alcohol (2.23 ml) and THF (30 ml) was added potassium tert-butoxide (4.67 g) at 5° C., followed by stirring for 0.5 hours. To this reaction mixture was added a mixture of tert-butyl 3,4,5-trifluorobenzoate (5 g) and THF (50 ml) at −65° C., followed by stirring at −65° C. for 1 hour and then stirring at room temperature for 5 hours. To the reaction mixture was added water (150 ml), followed by carrying out a separation of the layers using ether, and the organic layer was washed sequentially with water and a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. To a mixture of this residue and THF (80 ml) was added 10% palladium on activated carbon (500 mg), followed by stirring at room temperature for 2 hours under a hydrogen atmosphere (balloon pressure). The reaction mixture was filtered through Celite and washed with THF, and then the resulting filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:ethyl acetate=98:2 to 50:50) to obtain 3.22 g of tert-butyl 3,5-difluoro-4-hydroxybenzoate as a colorless solid. 
     Preparation Example 133 
     To a mixture of diisopropylamine (0.94 ml) and THF (10 ml) was added a 1.6 M n-butyllithium hexanesolution (4.4 ml) at −55° C. over 5 minutes, and then a solution of 2-chloro-3-cyclopropylthiophene (960 mg) in THF (5 ml) was added thereto at −68° C. over 10 minutes, followed by stirring for 50 minutes. Thereafter, to the reaction mixture was added dry ice, followed by returning to room temperature. To the reaction mixture were added water (30 ml) and a 1 M aqueous sodium hydroxide solution (10 ml), and then the aqueous layer was washed with hexane. To the aqueous layer was added 1 M hydrochloric acid (30 ml), followed by carrying out a separation of the layers using ethyl acetate, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure to obtain 765 mg of 5-chloro-4-cyclopropylthiophene-2-carboxylic acid as a pale yellow solid. 
     Preparation Example 134 
     To a mixture of methyl 4-chloro-3-hydroxybenzoate (500 mg), 5-chloro-2,3-difluoropyridine (801 mg), and DMF (10 ml) was added potassium carbonate (1.48 g), followed by stirring at 80° C. for 16 hours. The reaction mixture was returned to room temperature, and water was added thereto, followed by carrying out a separation of the layers using ethyl acetate. The organic layer was washed sequentially with water and a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=100:0 to 90:10) to obtain 521 mg of methyl 4-chloro-3-[(5-chloro-3-fluoropyridin-2-yl)oxy]benzoate as a colorless solid. 
     Preparation Example 135 
     A mixture of ethyl 3-chloro-4-(trifluoromethyl)benzoate (1 g), potassium cyclopropyltrifluoroborate (644 mg), 2-dichlorohexylphosphino-2′,4′,6′-triisopropylbiphenyl (189 mg), potassium carbonate (1.64 g), palladium(II) acetate (44 mg), THF (12 ml), and water (1.2 ml) was stirred at 100° C. for 12 hours using a microwave reactor. To the reaction mixture was added water, followed by carrying out a separation of the layers using ethyl acetate, and the organic layer was dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was crudely purified by silica gel column chromatography (hexane:ethyl acetate=95:5) to obtain an oil. Using this oil, the same operation was carried out, and then to the resulting oil were added MeOH (15 ml), EtOH (15 ml), and a 1 M aqueous sodium hydroxide solution (15 ml), followed by stirring at room temperature overnight. To the reaction mixture was added 1 M hydrochloric acid (15 ml), followed by concentrating under reduced pressure, and the organic solvent was evaporated. The precipitated solid was collected by filtration to obtain 120 mg of 3-cyclopropyl-4-(trifluoromethyl)benzoic acid as a colorless solid. 
     Preparation Example 136 
     To a mixture of N-{2-[(4-aminobenzoyl)amino]ethyl}-2-naphthamide hydrochloride (200 mg), ethyl 4-cyclohexanonecarboxylate (108 mg), sodium acetate (50 mg), and methylene chloride (5 ml) was added acetic acid (0.05 ml), followed by stirring at room temperature for 1 hour, and then sodium triacetoxyborohydride (180 mg) was added thereto, followed by stirring for 2 hours. Thereafter, DMF (2 ml) was added thereto, followed by stirring overnight. To the reaction mixture was added a saturated aqueous sodium hydrogen carbonate solution, followed by carrying out a separation of the layers using ethyl acetate, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:MeOH=100:0 to 95:5) to obtain 96 mg of ethyl 4-[(4-{[2-(2-naphthoylamino)ethyl]carbamoyl}phenyl)amino]cyclohexanecarboxylate as a colorless oil. 
     Preparation Example 137 
     To a mixture of benzyl 4-[(4-hydroxycyclohexyl)oxy]benzoate (800 mg), tert-butyl bromoacetate (726 mg), and THF (10 ml) was added 60% oily sodium hydride (110 mg), followed by stirring at room temperature for 16 hours. To the reaction mixture was added a saturated aqueous ammonium chloride solution, followed by carrying out a separation of the layers using ethyl acetate, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=95:5 to 75:25) to obtain 272 mg of benzyl 4-{[4-(2-tert-butoxy-2-oxoethoxy)cyclohexyl]oxy}benzoate as a colorless oil. 
     Preparation Example 138 
     A mixture of benzyl 4-(1,4-dioxaspiro[4.5]decan-8-yloxy)benzoate (3.0 g), 1 M hydrochloric acid (20 ml), THF (20 ml), and EtOH (20 ml) was stirred at room temperature overnight, and then stirred at 45° C. for 40 minutes. The reaction mixture was left to stand to room temperature, and 1 M hydrochloric acid (7.5 ml) was added thereto, followed by stirring at room temperature for 4.5 hours. The reaction mixture was concentrated under reduced pressure to remove EtOH and THF, followed by carrying out a separation of the layers using ethyl acetate. The organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=95:5 to 65:35) to obtain 2.5 g of benzyl 4-[(4-oxocyclohexyl)oxy]benzoate as a colorless oil. 
     Preparation Example 139 
     To a mixture of benzyl 4-[(dimethoxyphosphoryl)methyl]benzoate (1.44 g) and THF (6.8 ml) was added potassium tert-butoxide (448 mg) under ice-cooling, followed by stirring at 0° C. for 1 hour, and then ethyl 4-oxocyclohexanecarboxylate (680 mg) was added thereto, followed by stirring at 0° C. for 3 hours. To the reaction mixture were added ethyl acetate and water, followed by carrying out a separation of the layers using ethyl acetate, and the organic layer was washed sequentially with water and a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=90:10) to obtain an oil. To a mixture of this oil and THF (10 ml) was added 10% palladium on activated carbon (5 mg), followed by stirring at room temperature for 3 hours under a hydrogen atmosphere (balloon pressure). The reaction mixture was filtered through Celite and washed with THF, and then the resulting filtrate was concentrated under reduced pressure. To the resulting residue was added hexane (5 ml), and the precipitated solid was collected by filtration to obtain 10 mg of 4-{[4-(ethoxycarbonyl)cyclohexyl]methyl}benzoic acid as a colorless solid. 
     Preparation Example 140 
     A mixture of N-(2-{[4-(1,4-dioxaspiro[4.5]decan-8-yloxy)benzoyl]amino}ethyl)-2-naphthamide (2.0 g), water (20 ml), and acetic acid (100 ml) was stirring at 65° C. for 0.5 hours. The reaction mixture was concentrated under reduced pressure, then water was added thereto, and the precipitated solid was collected by filtration and washed with diisopropylether to obtain 1.8 g of N-[2-({4-[(4-oxocyclohexyl)oxy]benzoyl}amino)ethyl]-2-naphthamide as a colorless solid. 
     Example 1 
     To a mixture of ethyl trans-4-(4-{[2-(benzoylamino)ethyl]carbamoyl}phenoxy)cyclohexanecarboxylate (102 mg), EtOH (3 ml), and THF (3 ml) was added a 1 M aqueous sodium hydroxide solution (0.9 ml) at room temperature, followed by stirring at room temperature for 5 hours. The reaction mixture was concentrated under reduced pressure, and water was added thereto, followed by adjusting to pH 3 by the addition of 1 M hydrochloric acid. The precipitated solid was collected by filtration to obtain 85 mg of trans-4-(4-{[2-(benzoylamino)ethyl]carbamoyl}phenoxy)cyclohexanecarboxylic acid as a colorless solid. 
     Example 2 
     To a mixture of ethyl cis-4-{4-[(2-aminoethyl)carbamoyl]phenoxy}cyclohexanecarboxylate hydrochloride (100 mg), chloroform (1 ml), and triethylamine (0.11 ml) was added trans-2-phenylcyclopropyl isocyanate (45 mg), followed by stirring at room temperature for 3 hours, and then the reaction mixture was concentrated under reduced pressure to obtain a residue. To this residue were added EtOH (3 ml) and THF (3 ml), and then a 1 M aqueous sodium hydroxide solution (0.5 ml) was added thereto, followed by stirring at room temperature overnight. To the reaction mixture was added 1 M hydrochloric acid (2.5 ml), followed by stirring, and the precipitated solid was collected by filtration to obtain 110 mg of rel-cis-4-(4-{[2-({[(1R,2S)-2-phenylcyclopropyl]carbamoyl}amino)ethyl]carbamoyl}phenoxy)cyclohexanecarboxylic acid as a colorless solid. 
     Example 3 
     To a mixture of ethyl cis-4-{-4-[(2-aminoethyl)carbamoyl]phenoxy}cyclohexanecarboxylate hydrochloride (100 mg), 1-benzofuran-5-carboxylic acid (53 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride (65 mg), 1-hydroxybenzotriazole monohydrate (45 mg), and DMF (2 ml) was added triethylamine (0.12 ml), followed by stirring at room temperature for 6 hours. To the reaction mixture was added water (8 ml), followed by stirring, and then the precipitated solid was collected by filtration and dried to obtain a colorless solid. To this solid were added EtOH (3 ml) and THF (3 ml), and then a 1 M aqueous sodium hydroxide solution (1 ml) was added thereto, followed by stirring at room temperature overnight. To the reaction mixture was added 1 M hydrochloric acid (1.1 ml), followed by stirring, then concentrating under reduced pressure, and removal of EtOH and THF by evaporation. The precipitated solid was collected by filtration and washed with water to obtain 105 mg of cis-4-[4-({2-[(1-benzofuran-5-ylcarbonyl)amino]ethyl}carbamoyl)phenoxy]cyclohexanecarboxylic acid as a colorless solid. 
     Example 4 
     To a mixture of ethyl cis-4-{4-[(2-aminoethyl)carbamoyl]-2-fluorophenoxy}cyclohexanecarboxylate hydrochloride (52 mg), methylene chloride (2 ml), and triethylamine (0.05 ml) was added 3-fluoro-4-(trifluoromethyl)benzoyl chloride (0.027 ml) at 0° C., followed by stirring at room temperature overnight. The reaction mixture was concentrated under reduced pressure, then water was added thereto, and the precipitated solid was collected by filtration. To this solid were added MeOH (2 ml) and THF (2 ml), and then a 1 M aqueous sodium hydroxide solution (2 ml) was added thereto, followed by stirring at 50° C. for 2 hours. To the reaction mixture was added 1 M hydrochloric acid (2 ml), followed by removal of the solvent by concentrating under reduced pressure and evaporating the solvent, and the precipitated solid was collected by filtration to obtain 58 mg of cis-4-{2-fluoro-4-[(2-{[3-fluoro-4-(trifluoromethyl)benzoyl]amino}ethyl)carbamoyl]phenoxy}cyclohexanecarboxylic acid as a colorless solid. 
     Example 5 
     To a mixture of ethyl cis-4-{4-[(2-aminoethyl)carbamoyl]phenoxy}cyclohexanecarboxylate hydrochloride (100 mg), methylene chloride (5 ml), and triethylamine (0.045 ml) was added carbonyldiimidazole (48 mg) at 0° C., followed by stirring at 0° C. for 10 minutes, and then 1-phenylpiperazine (0.049 ml) was added thereto, followed by stirring at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform:MeOH=97.5:2.5) to obtain a colorless solid. To this solid were added EtOH (3 ml) and THF (3 ml), and then a 1 M aqueous sodium hydroxide solution (3 ml) was added thereto, followed by stirring at room temperature for 6 hours. To the reaction mixture was added 1 M hydrochloric acid (3 ml), then removal of EtOH and THF by concentrating under reduced pressure, and the precipitated solid was collected by filtration to obtain 70 mg of cis-4-{4-[(2-{[(4-phenylpiperazin-1-yl)carbonyl]amino}ethyl)carbamoyl]phenoxy}cyclohexanecarboxylic acid as a colorless solid. 
     Example 6 
     To a mixture of tert-butyl {4-[4-({2-[(4-chlorobenzoyl)amino]ethyl}carbamoyl)phenyl]cyclohexyl}acetate (197 mg) and methylene chloride (3 ml) was added trifluoroacetic acid (1 ml) at 0° C., followed by stirring at room temperature for 3 hours. The reaction mixture was concentrated under reduced pressure, then water was added thereto, and the precipitated solid was collected by filtration to obtain 140 mg of {4-[4-({2-[(4-chlorobenzoyl)amino]ethyl}carbamoyl)phenyl]cyclohexyl}acetic acid as a colorless solid. 
     Example 7 
     To a mixture of cis-4-[4-({2-[(4-chlorobenzoyl)amino]ethyl}carbamoyl)phenoxy]cyclohexanecarboxylic acid (100 mg), THF (4 ml), and DMF (1 ml) was added carbonyldiimidazole (55 mg), followed by stirring at 60° C. for 40 minutes, and methanesulfonamide (40 mg) and 1,8-diazabicyclo[5.4.0]undeca-7-ene (0.045 ml) were added thereto under ice-cooling, followed by stirring at room temperature for 3 days. To the reaction mixture were added 1 M hydrochloric acid (10 ml) and ethyl acetate (10 ml), and the insoluble materials were collected by filtration to obtain 41 mg of 4-chloro-N-(2-{[4-({cis-4-[(methylsulfonyl)carbamoyl]cyclohexyl}oxy)benzoyl]amino}ethyl)benzamide as a colorless solid. 
     Example 8 
     A mixture of cis-4-[4-({2-[(4-chlorobenzoyl)amino]ethyl}carbamoyl)phenoxy]cyclohexanecarboxylic acid (400 mg), ammonium chloride (60 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride (225 mg), 1-hydroxybenzotriazole monohydrate (160 mg), DMF (5 ml), and triethylamine (0.16 ml) was stirred at room temperature for 5 hours. To the reaction mixture was added water (10 ml), and the solid was collected by filtration and washed with water to obtain 372 mg of 4-[(cis-4-carbamoylcyclohexyl)oxy]-N-{2-[(4-chlorobenzoyl)amino]ethyl}benzamide as a colorless solid. 
     Example 9 
     A mixture of 4-chloro-N-[2-({4-[(cis-4-cyanocyclohexyl)oxy]benzoyl}amino)ethyl]benzamide (298 mg), sodium azide (220 mg), triethylamine hydrochloride (480 mg), and 1-methyl-2-pyrrolidinone (3 ml) was stirred at 140° C. for 11 hours. To the reaction mixture were added water and chloroform, and the insoluble materials were collected by filtration, and the solid was purified by silica gel column chromatography (chloroform:MeOH=95:5 to 80:20), and then the precipitated solid was washed with ethyl acetate to obtain 16 mg of 4-chloro-N-{2-[(4-{[cis-4-(1H-tetrazol-5-yl)cyclohexyl]oxy}benzoyl)amino]ethyl}benzamide as a brown solid. 
     Example 200 
     A mixture of N-(2-aminoethyl)-4-chlorobenzamide hydrochloride (32 mg), 4-{[cis-4-(ethoxycarbonyl)cyclohexyl]oxy}-2-methoxybenzoic acid (58 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride (35 mg), 1-hydroxybenzotriazole monohydrate (30 mg), THF (3 ml), and triethylamine (0.075 ml) was stirred at room temperature for 16 hours. To the reaction mixture was added water, followed by carrying out a separation of the layers using ethyl acetate, and the organic layer was washed sequentially with a saturated aqueous sodium hydrogen carbonate solution, 1 M hydrochloric acid, and a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. To the residue were added EtOH (2 ml), THF (2 ml), and a 1 M aqueous sodium hydroxide solution (0.6 ml), followed by stirring at 45° C. for 3 hours. To the reaction mixture were added 1 M hydrochloric acid (0.6 ml) and water (5 ml), followed by stirring and then removal of EtOH and THF by concentrating under reduced pressure. The residue was subjected to extraction with ethyl acetate, and the organic layer was washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. To the residue were added ethyl acetate and hexane, and the precipitated solid was collected by filtration and washed with water to obtain 46 mg of cis-4-[4-({2-[(4-chlorobenzoyl)amino]ethyl}carbamoyl)-3-methoxyphenoxy]cyclohexanecarboxylic acid as a colorless solid. 
     Example 201 
     To a mixture of N-{2-[(4-hydroxybenzoyl)amino]ethyl}-2-naphthamide (170 mg), methyl (trans-4-hydroxycyclohexyl)acetate (80 mg), triphenylphosphine (140 mg), and THF (2 ml) was added a 2.2 M diethyl azodicarboxylate solution in toluene (0.24 ml) at room temperature, followed by stirring at room temperature overnight. The reaction mixture was added to a saturated aqueous sodium hydrogen carbonate solution, followed by carrying out a separation of the layers using chloroform, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:MeOH=100:0 to 95:5), and to the resulting product were added EtOH (5 ml), THF (5 ml), and a 1 M aqueous sodium hydroxide solution (2 ml), followed by stirring at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and EtOH and THF was evaporated. To the residue was added water, followed by adjusting to pH 4 by the addition of a 10% aqueous citric acid solution, and the precipitated solid was collected by filtration. This solid was purified by silica gel column chromatography (chloroform:MeOH=100:0 to 90:10) to obtain 20 mg of [cis-4-(4-{[2-(2-naphthoylamino)ethyl]carbamoyl}phenoxy)cyclohexyl]acetic acid as a colorless solid. 
     Example 202 
     To a mixture of ethyl cis-4-(4-{[2-(2-naphthoylamino)ethyl]carbamoyl}phenoxy)cyclohexanecarboxylate (100 mg) and methylene chloride (3 ml) was added a 1.0 M diisobutylaluminum hydride solution in toluene (0.5 ml) under ice-cooling, followed by stirring at the same temperature for 45 minutes. Thereafter, a 1.0 M diisobutylaluminum hydride solution in toluene (0.5 ml) was added thereto, followed by stirring for 15 minutes, and a 1.0 M diisobutylaluminum hydride solution in toluene (0.5 ml) was added thereto again, followed by stirring for 1 hour. To the reaction mixture were added 1 M hydrochloric acid (5 ml) and a saturated aqueous potassium sodium tartrate solution (5 ml), followed by carrying out a separation of the layers using ethyl acetate, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:MeOH=98:2 to 90:10), to the resulting product were added ethyl acetate and hexane, and the precipitated solid was collected by filtration to obtain 20 mg of N-{2-[(4-{[cis-4-(hydroxymethyl)cyclohexyl]oxy}benzoyl)amino]ethyl}-2-naphthamide as a colorless solid. 
     Example 203 
     A mixture of cis-4-(4-{[2-(2-naphthoylamino)ethyl]carbamoyl}phenoxy)cyclohexanecarboxylic acid (50 mg), methaneamine hydrochloride (10 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride (30 mg), 1-hydroxybenzotriazole monohydrate (22 mg), DMF (1 ml), and triethylamine (0.05 ml) was stirred at room temperature overnight. To the reaction mixture was added water, and the precipitated solid was collected by filtration to obtain 48 mg of N-{2-[(4-{[cis-4-(methylcarbamoyl)cyclohexyl]oxy}benzoyl)amino]ethyl}-2-naphthamide as a colorless solid. 
     Example 204 
     A mixture of cis-4-(4-{[2-(2-naphthoylamino)ethyl]carbamoyl}phenoxy)cyclohexanecarboxylic acid (50 mg), tert-butyl (2-aminoethyl)carbamate (20 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride (30 mg), 1-hydroxybenzotriazole monohydrate (22 mg), DMF (1 ml), and triethylamine (0.04 ml) was stirred at room temperature overnight. To the reaction mixture was added water, and the precipitated solid was collected by filtration. To this solid were added dioxane (1 ml) and 4 M hydrochloric acid/ethyl acetate (1 ml), followed by stirring at room temperature for 4 hours. The reaction mixture was concentrated under reduced pressure, and the residue was solidified with diisopropylether and washed to obtain 28 mg of N-(2-{[4-({cis-4-[(2-aminoethyl)carbamoyl]cyclohexyl}oxy)benzoyl]amino}ethyl)-2-naphthamide hydrochloride as a colorless solid. 
     Example 205 
     A mixture of cis-4-(4-{[2-(2-naphthoylamino)ethyl]carbamoyl}phenoxy)cyclohexanecarboxylic acid (50 mg), glycine ethyl ester hydrochloride (18 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride (30 mg), 1-hydroxybenzotriazole monohydrate (22 mg), DMF (1 ml), and triethylamine (0.05 ml) was stirred at room temperature overnight. To the reaction mixture was added water, and the precipitated solid was collected by filtration. To this solid were added EtOH (2 ml), THF (2 ml), and a 1 M aqueous sodium hydroxide solution (0.5 ml), followed by stirring at 50° C. for 4 hours. The reaction mixture was concentrated under reduced pressure to remove EtOH and THF. To the residue was added water, followed by adjusting to pH 4 by the addition of a 10% aqueous citric acid solution, and the precipitated solid was collected by filtration to obtain 34 mg of N-{[cis-4-(4-{[2-(2-naphthoylamino)ethyl]carbamoyl}phenoxy)cyclohexyl]carbonyl}glycine as a colorless solid. 
     Example 206 
     A mixture of cis-4-(4-{[2-(2-naphthoylamino)ethyl]carbamoyl}phenoxy)cyclohexanecarboxylic acid (50 mg), 3-hydroxybutan-2-one (14 mg), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide monohydrochloride (30 mg), 1-hydroxybenzotriazole monohydrate (22 mg), DMF (1 ml), and triethylamine (0.04 ml) was stirred at room temperature overnight. To the reaction mixture was added water, and the precipitated solid was collected by filtration. To this solid were added acetic acid (2 ml) and ammonium acetate (50 mg), followed by refluxing overnight. To the reaction mixture were added water and a saturated aqueous sodium hydrogen carbonate solution, followed by carrying out a separation of the layers using chloroform, and the organic layer was washed with a saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (chloroform:MeOH=100:0 to 90:10) to obtain 4 mg of N-{2-[(4-{[cis-4-(4,5-dimethyl-1,3-oxazol-2-yl)cyclohexyl]oxy}benzoyl)amino]ethyl}-2-naphthamide as a colorless solid. 
     Example 207 
     To a mixture of N-[2-({4-[(4-oxocyclohexyl)oxy]benzoyl}amino)ethyl]-2-naphthamide (100 mg) and methanol (10 ml) was added sodium borohydride (9 mg) at 0° C., followed by stirring for 0.5 hours. The reaction mixture was concentrated under reduced pressure, and then 1 M hydrochloric acid was added thereto, followed by extracting with chloroform. The organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was washed with diisopropylether to obtain 48 mg of N-[2-({4-[(4-hydroxy cyclohexyl)oxy]benzoyl}amino)ethyl]-2-naphthamide as a colorless solid. 
     Example 208 
     To a mixture of N-[2-({4-[(4-oxocyclohexyl)oxy]benzoyl}amino)ethyl]-2-naphthamide (100 mg) and ether (10 ml) was added a 3.0 M methylmagnesium bromide ether solution (0.4 ml) at 0° C., followed by stirring for 0.5 hours. The reaction mixture was concentrated under reduced pressure, and then 1 M hydrochloric acid was added thereto, followed by carrying out a separation of the layers using chloroform. The organic layer was dried over anhydrous magnesium sulfate and then concentrated under reduced pressure. The residue was washed with diisopropyl ether to obtain 56 mg of N-[2-({4-[(4-hydroxy-4-methylcyclohexyl)oxy]benzoyl}amino)ethyl]-2-naphthamide as a colorless solid. 
     Example 209 
     A mixture of tert-butyl [cis-4-(4-{[2-(2-naphthoylamino)ethyl]carbamoyl}phenoxy)cyclohexyl]carbamate (623 mg) and 4 M hydrogen chloride/ethyl acetate (7 ml) was stirred at room temperature overnight. The reaction mixture was concentrated under reduced pressure, and to the resulting residue were added ethyl acetate, ethanol, and water at 100° C. to make a solution, followed by being left to cool at room temperature. Thereafter, the precipitated solid was collected by filtration to obtain 368 mg of N-[2-({4-[(cis-4-aminocyclohexyl)oxy]benzoyl}amino)ethyl]-2-naphthamide hydrochloride as a colorless solid. 
     Example 210 
     To a mixture of N-[2-({4-[(cis-4-aminocyclohexyl)oxy]benzoyl}amino)ethyl]-2-naphthamide hydrochloride (70 mg) and methylene chloride (3 ml) were added triethylamine (0.065 ml) and acetyl chloride (0.016 ml), followed by stirring at room temperature for 3 hours. Thereafter, the solvent was evaporated, to the residue was added water, followed by stirring for a while, and the solid was collected by filtration to obtain 69 mg of N-[2-({4-[(cis-4-acetamidecyclohexyl)oxy]benzoyl}amino)ethyl]-2-naphthamide as a colorless solid. 
     The chemical structural formulae of Preparation Example Compounds are shown in Tables 2 to 42 below. Further, the chemical structural formulae of Example Compounds are shown in Tables 43 to 133 below. 
     Moreover, the preparation methods and the physical data of Preparation Example Compounds are shown in Tables 134 to 144 below. Further, the preparation methods and the physical data of Example Compounds are shown in Tables 145 to 169 below. 
     
       
         
           
               
               
             
               
                 TABLE 2 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                     4/ Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 8 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 3 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                  9 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 11 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 15 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                   
                 TABLE 4 
               
               
                   
                   
               
               
                   
                 Pr 
                 Structure 
               
               
                   
                   
               
             
            
               
                   
                 16 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 17 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 18 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 19 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 20 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 21 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 22 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                 23 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 5 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 24 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 25 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 26 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 27 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                     28/ Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 29 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                     30/ Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 31 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 6 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 32 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 33 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 34 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 35 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 36 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 37 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 38 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 7 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 39 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 40 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 41 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 42 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 43 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 44 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 45 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 8 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 46 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 47 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 48 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 49 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 50 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 51 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 52 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 53 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 9 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 54 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 55 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 56 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 57 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 58 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 59 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 60 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 10 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 61 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 62 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 63 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 64 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 65 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 66 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 67 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 68 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 11 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 69 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 70 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 71 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 72 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 73 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 74 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 75 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 76 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 12 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 77 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 78 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 79 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 80 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 81 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 82 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 83 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                     84/ Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 13 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 85 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 86 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 87 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 88 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 89 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 90 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 91 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 14 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 92 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 93 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 94 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 95 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 96 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 97 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 15 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                  98 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                  99 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 100 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 101 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 102 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 103 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                     104/ Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 105 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 106 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 16 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 107 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 108 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                     109/ Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 110 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 111 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 112 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 113 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 114 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 115 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 17 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 116 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 117 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 118 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 119 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 120 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                     121/ Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 122 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 123 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 18 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 124 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 125 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 126 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 127 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 128 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 129 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 130 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                     131/ Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 19 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 132 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 133 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 134 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 135 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 136 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 137 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 138 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 139 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 20 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 140 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                     141/ TF 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 142 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 143 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 144 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 145 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 146 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 147 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 21 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 148 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 149 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 150 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 151 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 152 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 153 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 154 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 155 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 156 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 22 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 157 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 158 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 159 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 160 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 161 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 162 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 163 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                     164/ Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 165 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 23 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 166 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 167 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 168 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 169 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 170 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 171 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 172 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 173 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 24 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 174 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 175 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 176 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 177 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                     178/ Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 179 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                     180/ Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 181 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 25 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 182 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 183 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 184 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                     185/ Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                     186/ Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                     187/ Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 188 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 26 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 189 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 190 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 191 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 192 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 193 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 194 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 195 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 27 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                     196/ Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 197 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 198 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 199 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 200 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                     201/ Cl  
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 202 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 28 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 203 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 204 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 205 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 206 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 207 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 208 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 29 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                 209 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 210 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 211 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 212* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 213* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 214 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 30 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 215 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 216/Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 217 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 218 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 219/Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 220 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 31 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 221 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 222 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 223 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 224 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 225/Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 226 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 227 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 228/Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 32 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 229 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 230 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 231/Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 232 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 233 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 234 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 235 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 236/Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 33 
               
               
                   
               
               
                   
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                   
                 237 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 238 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 239 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 240 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 241 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 242 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 243 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 244 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 34 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 245 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 246 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 247/Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 248 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 249 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 250/Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 251 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 35 
               
               
                   
               
               
                   
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                   
                 252 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 253 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 254 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 255 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 256 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 257 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 258 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 36 
               
               
                   
               
               
                   
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                   
                 259 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 260 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 261 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 262/Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 263 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 264 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 265 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 266 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 267 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 37 
               
               
                   
                   
               
               
                   
                   
                 Pr 
                 Structure 
               
               
                   
                   
               
             
            
               
                   
                   
                 268 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                   
                 269 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                   
                 270 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                   
                 271 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                   
                 272 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                   
                 273 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                   
                 274 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
               
                   
                   
                 275 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 38 
               
               
                   
               
               
                   
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                   
                 276 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 277 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 278 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 279 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 280 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 281 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 282 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 283 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 39 
               
               
                   
               
               
                   
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                 284 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 285 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 286 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 287 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 288* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 289* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 290* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                   
                 291* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 40 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 292 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 293 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 294 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 295 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 296/Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 297 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 298 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 299 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 300 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 41 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 301 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 302 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 303 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 304 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 305 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 306 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 307 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 308 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 309 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 42 
               
               
                   
               
               
                 Pr 
                 Structure 
               
               
                   
               
             
            
               
                 310 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 311 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 312 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 313 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 314 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 43 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 3 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 4 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 5 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 6 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 44 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                  8 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                  9 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 11 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 15 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 45 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 16 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 17 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 18 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 19 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 20 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 21 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 22 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 46 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 23 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 24 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 25 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 26 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 27 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 28 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 29 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 47 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 30 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 31 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 32 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 33 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 34 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 35 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 36 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 37 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 48 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 38 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 39 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 40 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 41 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 42 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 43 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 44 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 45 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 49 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 46 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 47 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 48 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 49 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 50 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 51 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 52 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 53 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 50 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 54 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 55 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 56 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 57 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 58 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 59 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 60 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 61 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 51 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 62 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 63 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 64 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 65 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 66 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 67 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 68 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 69 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 52 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 70 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 71 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 72 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 73 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 74 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 75 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 76 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 53 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 77 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 78 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 79 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 80 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 81 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 82 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 83 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 84 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 54 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 85 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 86 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 87 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 88 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 89 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 90 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 91 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 92 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 55 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                 93 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 94 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 95 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 96 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 97 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 98 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 99 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 100 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 56 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 101 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 102 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 103 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 104 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 105 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 106 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 107 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 108 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 57 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 109 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 110 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 111 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 112 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 113 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 114 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 115 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 116 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 58 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 117 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 118 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 119 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 120 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 121 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 122 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 123 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 59 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 124 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 125 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 126 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 127 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 128 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 129 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 130 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 60 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 131 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 132 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 133 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 134 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 135 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 136 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 137 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 61 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 138 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 139 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 140 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 141 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 142 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 143 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 144 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 62 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 145 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 146 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 147 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 148 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 149 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 150 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 151 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 63 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 152 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 153 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 154 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 155 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 156 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 157 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 158 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 64 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 159 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 160 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 161 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 162 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 163 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 164 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 165 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 65 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 166 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 167 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 168 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 169 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 170 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 171 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 172 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 66 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 173 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 174 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 175 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 176 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 177 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 178 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 179 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 67 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 180 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 181 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 182 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 183 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 184 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 185 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 186 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 68 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 187 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 188 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 189 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 190 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 191 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 192 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 193 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 69 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 194 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 195 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 196 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 197 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 198 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 199 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 200 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 201 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 70 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 202 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 203 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 204/Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 205 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 206 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 207 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 208 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 209/Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 71 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 210 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 211 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 212 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 213 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 214 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 215 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 216 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 217 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 72 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 218 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 219 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 220 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 221 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 222 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 223 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 224 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 73 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 225 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 226 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 227 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 228 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 229 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 230 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 231 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 232 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 74 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 233 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 234 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 235 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 236 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 237 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 238 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 239 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 240 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 75 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 241 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 242 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 243 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 244 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 245 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 246 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 247 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 248 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 76 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 249 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 250 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 251 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 252 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 253 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 254 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 255 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 77 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 256 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 257 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 258 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 259 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 260 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 261 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 262 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 263 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 78 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 264 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 265 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 266 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 267 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 268 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 269 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 270 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 271 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 79 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 272 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 273 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 274 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 275 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 276 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 277 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 278 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 80 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 279 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 280 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 281 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 282 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 283 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 284 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 285 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 286 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 81 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 287 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 288 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 289 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 290 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 291 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 292 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 293 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 294 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 82 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 295 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 296 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 297 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 298 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 299 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 300 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 301 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 302 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 83 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 303 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 304 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 305 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 306 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 307 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 308 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 309 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 84 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 310 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 311 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 312 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 313 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 314 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 315 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 316 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                  317* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 85 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                  318* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                  319* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                  320* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 321 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 322 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 323 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 324 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 325 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 86 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 326 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 327 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 328 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 329 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 330 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 331 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 332 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 87 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 333 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 334 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 335 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 336 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 337 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 338 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 339 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 88 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 340 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 341 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 342 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 343 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 344 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 345 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 346 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 89 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 347 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 348 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 349 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 350 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 351 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 352 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 353 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 90 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 354 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 355 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 356 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 357 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 358 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 359 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 360 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 361 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 91 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 362 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 363 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 364 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 365 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 366 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 367 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 368 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 369 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 92 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 370 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 371 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 372 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 373 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 374 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 375 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 376 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 93 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 377 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 378 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 379 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 380 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 381 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 382 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 383 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 94 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 384 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 385 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 386 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 387 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 388 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 389 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 95 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 390 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 391 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 392 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 393 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 394 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 395 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 396 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 96 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 397 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 398 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 399 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 400 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 401 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 402 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 403 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 404 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 97 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 405 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 406 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 407 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 408* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 409* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 410 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 98 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 411 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 412 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 413 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 414 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 415 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 416 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 417* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 418 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 99 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 419 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 420 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 421 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 422 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 423 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 424 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 425 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 100 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 426 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 427 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 428 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 429 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 430 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 431 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 432 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 433 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 101 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 434 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 435 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 436 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 437 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 438 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 439 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 440 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 102 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 441 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 442 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 443 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 444 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 445 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 446 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 447 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 103 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 448 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 449 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 450 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 451 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 452 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 453 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 104 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 454 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 455 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 456 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 457 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 458 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 459 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 105 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 460 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 461 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 462 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 463 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 464 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 465 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 466 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 106 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 467 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 468 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 469 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 470 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 471 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 472 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 473 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 107 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 474 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 475 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 476 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 477 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 478 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 479 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 108 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 480 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 481 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 482 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 483 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 484 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 485 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 486 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 109 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 487 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 488 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 489 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 490 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 491 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 492 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 493 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 494 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 110 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 495 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 496 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 497 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 498 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 499 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 500 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 501 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 111 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 502 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 503 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 504 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 505 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 506 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 507 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 112 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 508 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 509 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 510 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 511 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 512 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 113 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 513 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 514 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 515 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 516 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 517 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 114 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 518 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 519 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 520 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 521 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 522 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 523 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 115 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 524 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 525 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 526 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 527 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 528 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 529 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 116 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 530 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 531 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 532 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 533 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 534 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 535 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 536 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 117 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 537 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 538 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 539 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 540 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 541 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 542 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 543 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 118 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 544 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 545 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 546 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 547 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 548 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 549 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 119 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 550 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 551 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 552 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 553 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 554 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 555 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 120 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 556  
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 557 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 558 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 559 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 560 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 561  
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 121 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 562 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 563 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 564 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 565 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 566 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 567 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 568 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 122 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 569 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 570 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 571 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 572 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 573 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 574 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 575 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 123 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 576 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 577 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 578 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 579 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 580 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 581 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 582 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 124 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 583 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 584 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 585 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 586 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 587 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 588 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 589 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 125 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 590 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 591 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 592 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 593 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 594 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 595 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 596 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 126 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 597 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 598 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 599 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 600 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 601 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 602 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 603 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 127 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 604 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 605 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 606 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 607 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 608 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 609 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 128 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 610 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 611 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 612 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 613 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 614 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 615 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 616 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 129 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 617 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 618 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 619 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 620 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 621 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 622 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 130 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 623 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 624 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 625 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 626 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 627 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 628 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 131 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 629 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 630 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 631 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 632* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 633 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 634 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 635 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 636 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 132 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 637 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 638 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 639 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 640 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 641 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 642 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 643 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 644 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                 TABLE 133 
               
               
                   
               
               
                 Ex 
                 Structure 
               
               
                   
               
             
            
               
                 645 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 646 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 647 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 648 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 649 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 650 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 651 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 652 
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 134 
               
               
                   
               
               
                 Pr  
                 PSy 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 1 
                 1 
                 NMR2: 1.26 (3H, t), 1.60-1.81 (4H, m), 1.89-2.06 (4H, m),  
               
               
                   
                   
                 2.36-2.45 (1H, m), 4.15 (2H, q), 4.54-4.60 (1H, m), 5.34  
               
               
                   
                   
                 (2H, s), 6.91 (2H, d), 7.30-7.46 (5H, m), 8.01 (2H, d). 
               
               
                 2 
                 2 
                 NMR2: 1.27 (3H, t), 1.64-1.83 (4H, m), 1.91-2.08 (4H, m),  
               
               
                   
                   
                 2.38-2.46 (1H,m), 4.15 (2H, q), 4.57-4.63 (1H, m), 6.94 
               
               
                   
                   
                 (2H, d), 8.04 (2H, d). 
               
               
                 3 
                 3 
                 ESP: 435. 
               
               
                 4 
                 4 
                 ESP: 335. 
               
               
                 5 
                 5 
                 ESP: 454. 
               
               
                 6 
                 6 
                 ESP: 522. 
               
               
                 7 
                 7 
                 ESP: 521. 
               
               
                 8 
                 8 
                 ESP: 439. 
               
               
                 9 
                 9 
                 ESN: 335. 
               
               
                 10 
                 10 
                 ESP: 491. 
               
               
                 11 
                 11 
                 EI: 238 
               
               
                 12 
                 12 
                 ESN: 245. 
               
               
                 13 
                 13 
                 ESN: 424. 
               
               
                 14 
                 14 
                 NMR2: 1.49 (9H, s), 1.60-1.70 (2H, m), 1.96-2.10 (3H, m),  
               
               
                   
                   
                 2.28-2.42 (2H, m), 2.84 (1H, tt), 3.90 (3H, s), 3.91-3.99  
               
               
                   
                   
                 (1H, m), 5.62 (1H, s), 7.27 (2H, d), 7.96 (2H, d). 
               
               
                 15 
                 15 
                 NMR2: 1.13-1.27 (1.4H, m), 1.42-1.60 (1.4H, m), 1.66-2.00  
               
               
                   
                   
                 (5.9H, m), 2.29-2.38 (1.7H, m), 2.48-2.59 (1.3H, m), 2.62-2.72  
               
               
                   
                   
                 (0.3H, m), 3.89-3.91 (3H, m), 7.27 (1.4H, d), 7.30 (0.6H, d),  
               
               
                   
                   
                 7.94-7.99 (2H, m). 
               
               
                 16 
                 16 
                 NMR2: 1.09-1.22 (1.4H, m), 1.48-1.57 (1.4H, m), 1.61-1.94  
               
               
                   
                   
                 (5.9H, m), 2.18 (1.4H, d), 2.24-2.36 (0.9H, m) 2.52 (0.7H, tt),  
               
               
                   
                   
                 2.60-2.70 (0.3H, m), 3.89-3.91 (3H, m), 7.27 (1.4H, d), 7.30  
               
               
                   
                   
                 (0.6H, d), 7.94-7.98 (2H, m). 
               
               
                 17  
                 17 
                 NMR1: 1.05-1.19 (1.4H, m), 1.41-1.54 (1.4H, m), 1.55-1.84  
               
               
                   
                   
                 (5.9H, m), 2.09-2.18 (1.7H, m), 2.32-2.36 (0.6H, m), 2.51-2.56  
               
               
                   
                   
                 (1H, m), 7.34 (1.4H, d), 7.39 (0.6H, d), 7.83-7.87 (2H, m). 
               
               
                 18  
                 18 
                 ESN: 239. 
               
               
                 19  
                 19 
                 ESN: 209. 
               
               
                 20 
                 20 
                 ESN: 179. 
               
               
                 21 
                 21 
                 NMR2: 0.73-0.78 (2H, m), 1.07-1.13 (2H, m), 1.39 (3H, t),  
               
               
                   
                   
                 2.24-2.32 (1H, m), 4.36 (2H, q), 6.93 (1H, d), 7.82 (1H, dd), 
               
               
                   
                   
                 8.02 (1H, d). 
               
               
                 22  
                 22 
                 NMR1: 0.77-0.82 (2H, m), 1.06-1.12 (2H, m), 2.19-2.27  
               
               
                   
                   
                 (1H, m), 7.12 (1H, d), 7.77 (1H, dd), 7.88 (1H, d). 
               
               
                 23 
                 23 
                 FP: 267. 
               
               
                 24  
                 24 
                 FN: 237. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 135 
               
               
                   
               
               
                 Pr  
                 PSy 
                 Data 
               
               
                   
               
             
            
               
                 25 
                 1 
                 NMR2: 1.26 (3H, t), 1.45-1.67 (4H, m), 2.05-2.23 (4H, m),  
               
               
                   
                   
                 2.31-2.40 (1H, m), 4.14 (2H, q), 4.25-4.34 (1H, m), 5.33 
               
               
                   
                   
                 (2H, s), 6.89 (2H, d), 7.30-7.46 (5H, m), 8.01 (2H, d). 
               
               
                 26 
                 2 
                 NMR2: 1.27 (3H, t), 1.47-1.69 (4H, m), 2.06-2.24 (4H, m),  
               
               
                   
                   
                 2.32-2.41(1H, m), 4.15 (2H, q), 4.28-4.37 (1H, m),6.92 (2H, d), 
               
               
                   
                   
                 8.04 (2H, d). 
               
               
                 27 
                 3  
                 NMR2: 1.27 (3H, t), 1.43 (9H, s), 1.44-1.68 (4H, m),  
               
               
                   
                   
                 2.04-2.22 (4H,m), 2.30-2.40 (1H, m), 3.34-3.44 (2H, m),  
               
               
                   
                   
                 3.50-3.57 (2H, m), 4.14 (2H, q), 4.23-4.32 (1H, m), 4.92-5.01  
               
               
                   
                   
                 (1H, m), 6.89 (2H, d), 6.96-7.04 (1H, m), 7.76 (2H, d). 
               
               
                 28 
                 4 
                 NMR1: 1.18 (3H, t), 1.35-1.62 (4H, m), 1.90-2.11 (4H, m),  
               
               
                   
                   
                 2.31-2.41 (1H, m), 2.93-3.01 (2H, m), 3.44-3.52 (2H, m), 4.07  
               
               
                   
                   
                 (2H, q), 4.38-4.47 (1H, m), 7.02 (2H, d), 7.84 (2H, d),  
               
               
                   
                   
                 7.93 (2H, bs). 
               
               
                 29 
                 3 
                 NMR2: 1.27 (3H, t), 1.43 (9H, s), 1.44-1.80 (4H, m),  
               
               
                   
                   
                 1.90-2.22(4H, m), 2.31-2.45 (1H, m), 3.36-3.44 (2H, m),  
               
               
                   
                   
                 3.51-3.57 (2H, m), 4.11-4.18 (2H, m), 4.28 (0.5H, tt)  
               
               
                   
                   
                 4.53-4.57 (0.5H, m), 4.93-5.00 (1H, m), 6.87-6.93(2H, m), 
               
               
                   
                   
                 6.97-7.04 (1H, m), 7.75 (2H, d). 
               
               
                 30 
                 4 
                 NMR1: 1.18 (3H, t), 1.42 (1H, dq), 1.55 (1H, dq), 1.64-1.85  
               
               
                   
                   
                 (4H, m), 1.91-1.98 (1H, m), 2.03-2.11 (1H, m), 2.36 (0.5H, tt),  
               
               
                   
                   
                 2.47-2.51 (0.5H, m), 2.97 (2H, t), 3.49 (2H, q), 4.03-4.10,  
               
               
                   
                   
                 (2H, m) 4.43 (0.5H, tt), 4.62-4.67 (0.5H, m), 6.99-7.04  
               
               
                   
                   
                 (2H, m), 7.82-7.86 (2H, m), 7.93 (2H, bs), 8.52-8.57 (1H, m). 
               
               
                 31 
                 9 
                 ESP: 499. 
               
               
                 32 
                 8 
                 ESP: 439. 
               
               
                 33 
                 8 
                 ESP: 473. 
               
               
                 34 
                 8 
                 ESP: 439. 
               
               
                 35 
                 8 
                 ESN: 471. 
               
               
                 36 
                 7 
                 ESP: 555. 
               
               
                 37 
                 7 
                 ESP: 555. 
               
               
                 38 
                 8 
                 ESP: 483. 
               
               
                 39 
                 8 
                 ESP: 483. 
               
               
                 40 
                 7 
                 ESP: 541. 
               
               
                 41 
                 8 
                 ESP: 473. 
               
               
                 42 
                 8 
                 ESP: 473. 
               
               
                 43 
                 7 
                 ESP: 527. 
               
               
                 44 
                 7 
                 ESP: 555. 
               
               
                 45 
                 7 
                 ESP: 555. 
               
               
                 46 
                 7 
                 ESP: 457. 
               
               
                 47 
                 7  
                 ESP: 479. 
               
               
                 48 
                 9  
                 ESN: 335. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 136 
               
               
                   
                   
               
               
                   
                 Pr 
                 PSy 
                 Data 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 49 
                 10 
                 ESP: 491. 
               
               
                   
                 50 
                 7 
                 ESP: 445. 
               
               
                   
                 51  
                 7  
                 ESP: 445. 
               
               
                   
                 52 
                 7 
                 ESP: 479. 
               
               
                   
                 53 
                 7  
                 ESP: 507. 
               
               
                   
                 54 
                 8  
                 ESP: 445. 
               
               
                   
                 55 
                 8 
                 ESP: 469. 
               
               
                   
                 56 
                 8 
                 ESP: 457. 
               
               
                   
                 57 
                 8 
                 ESP: 523. 
               
               
                   
                 58  
                 7 
                 ESP: 555. 
               
               
                   
                 59  
                 7 
                 ESP: 517. 
               
               
                   
                 60  
                 7 
                 ESP: 517. 
               
               
                   
                 61  
                 7 
                 ESP: 507. 
               
               
                   
                 62 
                 7 
                 ESP: 507. 
               
               
                   
                 63  
                 7 
                 ESP: 479. 
               
               
                   
                 64 
                 7 
                 ESP: 503. 
               
               
                   
                 65  
                 7 
                 ESP: 515. 
               
               
                   
                 66 
                 8 
                 ESP: 525. 
               
               
                   
                 67  
                 8  
                 ESP: 489. 
               
               
                   
                 68 
                 7 
                 ESP: 489. 
               
               
                   
                 69 
                 9 
                 ESP: 320. 
               
               
                   
                 70  
                 10 
                 ESP: 474. 
               
               
                   
                 71 
                 9 
                 ESP: 320. 
               
               
                   
                 72  
                 10 
                 ESP: 474. 
               
               
                   
                 73 
                 9 
                 ESP: 333. 
               
               
                   
                 74 
                 10  
                 ESP: 487. 
               
               
                   
                 75  
                 9 
                 ESP: 487. 
               
               
                   
                 76 
                 1 
                 ESP: 397. 
               
               
                   
                 77  
                 2 
                 ESP: 307. 
               
               
                   
                 78 
                 7 
                 ESP: 541. 
               
               
                   
                 79 
                 7 
                 ESP: 557. 
               
               
                   
                 80 
                 8 
                 ESP: 525. 
               
               
                   
                 81 
                 1 
                 ESP: 401. 
               
               
                   
                 82 
                 2 
                 ESN: 309. 
               
               
                   
                 83  
                 3 
                 ESP: 453. 
               
               
                   
                 84 
                 4 
                 ESP: 353. 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 137 
               
               
                   
               
               
                 Pr 
                 PSy 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 85  
                 7 
                 ESP: 487. 
               
               
                 86 
                 7  
                 ESP: 513. 
               
               
                 87 
                 7 
                 ESP: 541. 
               
               
                 88 
                 9 
                 ESP: 349. 
               
               
                 89 
                 10 
                 ESP: 503. 
               
               
                 90 
                 9 
                 ESN: 351. 
               
               
                 91 
                 10 
                 ESN: 505. 
               
               
                 92 
                 9 
                 ESN: 351. 
               
               
                 93 
                 10 
                 ESN: 505. 
               
               
                 94  
                 7 
                 ESP: 521. 
               
               
                 95 
                 8 
                 ESP: 521. 
               
               
                 96  
                 8 
                 ESP: 521. 
               
               
                 97  
                 8 
                 ESP: 497. 
               
               
                 98 
                 7 
                 ESP: 531. 
               
               
                 99  
                 7 
                 ESP: 501. 
               
               
                 100  
                 12 
                 ESN: 245. 
               
               
                 101 
                 1 
                 ESP: 401. 
               
               
                 102 
                 2 
                 ESN: 309. 
               
               
                 103 
                 3 
                 ESP: 453. 
               
               
                 104 
                 4 
                 ESP: 353. 
               
               
                 105  
                 12 
                 ESP: 243. 
               
               
                 106  
                 1 
                 ESP: 397. 
               
               
                 107 
                 2 
                 ESP: 307. 
               
               
                 108 
                 3 
                 ESP: 449. 
               
               
                 109 
                 4 
                 NMR1: 1.18 (3H, t), 1.60-1.89 (8H, m), 2.35 (3H, s), 2.89-3.01 
               
               
                   
                   
                 (2H, m), 3.44-3.51 (2H ,m), 4.08 (2H, q), 4.56-4.65 (1H, m),  
               
               
                   
                   
                 6.77-6.85(2H, m), 7.42 (1H, d), 7.94 (2H, bs), 8.22-8.32 
               
               
                   
                   
                 (1H, m). 
               
               
                   
                   
                 ESP: 349. 
               
               
                 110 
                 18 
                 ESN: 223. 
               
               
                 111 
                 19 
                 ESN: 223. 
               
               
                 112 
                 21 
                 FP: 221. 
               
               
                 113 
                 22 
                 FP: 207. 
               
               
                 114 
                 23 
                 FP: 267. 
               
               
                 115 
                 24 
                 FP: 237. 
               
               
                 116 
                 116 
                 ESN: 280. 
               
               
                 117 
                 117 
                 NMR1: 1.17 (3H, t), 1.36 (9H, s), 1.66-1.87 (8H, m),  
               
               
                   
                   
                 2.44-2.48 (1H, m), 3.08 (2H, q), 3.26 (2H, q), 4.04 (2H, q), 
               
               
                   
                   
                 5.19-5.24 (1H, m), 6.86 (1H, d), 6.92 (1H, t), 8.08 (1H, dd), 
               
               
                   
                   
                 8.44 (1H, t), 8.60 (1H, d). 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 138 
               
               
                   
               
               
                 Pr  
                 PSy 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 118 
                 118 
                 ESN: 411. 
               
               
                 119 
                 119 
                 ESP: 423. 
               
               
                 120 
                 120 
                 ESN: 295. 
               
               
                 121 
                 121 
                 ESP: 369. 
               
               
                 122 
                 122 
                 ESN: 379. 
               
               
                 123 
                 123 
                 ESP: 471. 
               
               
                 124 
                 124 
                 NMR2: 1.23-1.36 (2H, m), 1.26 (3H, t), 1.45-1.67 (6H, m),  
               
               
                   
                   
                 1.97-2.06 (2H, m), 2.53-2.59 (1H, m), 3.50 (2H, d), 
               
               
                   
                   
                 4.14 (2H, q). 
               
               
                 125 
                 125 
                 NMR2: 1.15 (3H, s), 1.15-1.24 (2H, m), 1.26 (3H, t), 1.30-1.39  
               
               
                   
                   
                 (2H, m), 1.58 (1H, s), 1.83-1.90 (2H, m), 2.18-2.26 (2H, m),  
               
               
                   
                   
                 3.55-3.64 (1H, m), 4.15 (2H, q). 
               
               
                 126 
                 126 
                 ESP: 579. 
               
               
                 127 
                 127 
                 ESP: 368. 
               
               
                 128 
                 128 
                 ESN: 327. 
               
               
                 129 
                 129 
                 ESN: 229. 
               
               
                 130 
                 130 
                 NMR1: 3.01-3.06 (2H, m), 3.55-3.62 (2H, m), 7.57-7.65  
               
               
                   
                   
                 (2H, m), 7.97-8.04 (4H, m), 8.08 (2H, s), 8.55 (1H, s), 
               
               
                   
                   
                 8.91-9.56 (1H, m). 
               
               
                 131 
                 131 
                 NMR1: 2.82-2.96 (2H, m), 3.27-3.42 (2H, m), 6.93-6.99  
               
               
                   
                   
                 (1H, m), 7.22-7.27 (1H, m), 7.37-7.43 (1H, m), 7.59-7.67  
               
               
                   
                   
                 (1H, m), 8.08-8.28 (4H, m). 
               
               
                 132 
                 132 
                 ESN: 229. 
               
               
                 133 
                 133 
                 NMR1: 0.72-0.78 (2H, m), 0.94-1.02 (2H, m), 1.86-1.96  
               
               
                   
                   
                 (1H, m), 7.25 (1H, s), 12.9-13.7 (1H, br). 
               
               
                 134 
                 134 
                 ESP: 315. 
               
               
                 135 
                 135 
                 ESN: 229. 
               
               
                 136 
                 136 
                 ESP: 487. 
               
               
                 137 
                 137 
                 NMR1: 1.99-2.08 (2H, m), 2.10-2.20 (2H, m), 2.31-2.47  
               
               
                   
                   
                 (4H, m), 4.90-4.97 (1H, m), 5.32 (2H, s), 7.15 (2H, d), 7.32-7.48  
               
               
                   
                   
                 (5H, m), 7.96 (2H,d). 
               
               
                 138 
                 138 
                 NMR1: 1.20-2.06 (8H, m), 1.42 (9H, s), 3.38-3.51  
               
               
                   
                   
                 (0.7, m), 3.99 (1.3H, d), 4.15 (0.7H, d), 4.45-4.66 (1H, m), 
               
               
                   
                   
                 4.79-4.92 (0.3H, m), 5.31 (2H, s), 7.03-7.11 (2H, m), 
               
               
                   
                   
                 7.32-7.48(5H, m), 7.90-7.95 (2H, m). 
               
               
                 139 
                 139 
                 ESN: 289. 
               
               
                 140 
                 140 
                 ESP: 431. 
               
               
                 141 
                 4 
                 ESP: 336. 
               
               
                 142 
                 7 
                 ESP: 508. 
               
               
                 143  
                 7 
                 ESP: 518. 
               
               
                 144  
                 7  
                 ESN: 480. 
               
               
                 145 
                 8 
                 ESP: 501. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 139 
               
               
                   
               
               
                 Pr 
                 PSy 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 146 
                 8 
                 ESP: 541. 
               
               
                 147  
                 7 
                 ESP: 505. 
               
               
                 148 
                 7 
                 ESP: 501. 
               
               
                 149 
                 2  
                 ESP: 323. 
               
               
                 150 
                 1 
                 ESN: 397. 
               
               
                 151 
                 12 
                 NMR1: 5.34 (2H, s), 6.34 (1H, d), 6.38 (1H, dd), 7.32-7.50  
               
               
                   
                   
                 (5H, m), 7.67 (1H, d), 10.38-10.62 (1H, br), 10.69 (1H, s). 
               
               
                 152 
                 2 
                 ESN: 391. 
               
               
                 153  
                 1 
                 NMR2: 1.26 (3H, t), 1.61-1.82 (4H, m), 1.86-2.04 (4H, m), 2.35- 
               
               
                   
                   
                 2.45 (1H, m), 4.15 (2H, q), 4.50-4.56 (1H, m), 5.34 (2H, s),  
               
               
                   
                   
                 6.78-6.82 (m, 1H), 6.97 (1H, d), 7.31-7.47 (5H, m), 7.89 (1H, d). 
               
               
                 154  
                 12 
                 ESP: 262, 264. 
               
               
                 155 
                 10 
                 ESN: 471. 
               
               
                 156  
                 10 
                 ESN: 471. 
               
               
                 157  
                 9 
                 NMR1: 1.18 (3H, t), 1.62-1.88 (8H, m), 2.42-2.55 (1H, m), 3.33- 
               
               
                   
                   
                 3.48 (4H, m), 4.06 (2H, q), 4.67-4.78 (1H, m), 7.21-7.35 (2H, m), 
               
               
                   
                   
                 7.45-7.61 (3H, m), 7.85 (2H, d), 8.43-8.68 (2H, m) 
               
               
                 158  
                 2 
                 ESP: 361. 
               
               
                 159 
                 1  
                 ESN: 449. 
               
               
                 160  
                 12 
                 NMR2: 5.37 (2H, s), 7.2-7.55 (7H, m), 7.82-7.96 (1H, m) 
               
               
                 161 
                 2 
                 ESN: 325, 327. 
               
               
                 162 
                 2 
                 ESN: 307. 
               
               
                 163 
                 9 
                 ESP: 523. 
               
               
                 164 
                 121 
                 NMR1: 2.37 (3H, s), 2.90-3.03 (2H, m), 3.47-3.59 (2H, m), 7.52 
               
               
                   
                   
                 (1H, d), 7.77 (1H, dd), 7.95 (1H, d), 8.16 (2H, s), 8.83-8.89 (1H, s). 
               
               
                 165 
                 2 
                 FP: 329. 
               
               
                 166  
                 1 
                 FP: 419. 
               
               
                 167 
                 12 
                 ESP: 265. 
               
               
                 168 
                 8 
                 ESP: 517. 
               
               
                 169 
                 8 
                 ESP: 557. 
               
               
                 170 
                 7 
                 ESN: 539. 
               
               
                 171 
                 7 
                 ESP: 551. 
               
               
                 172 
                 7 
                 ESP: 541. 
               
               
                 173 
                 7 
                 ESP: 521. 
               
               
                 174  
                 7 
                 ESP: 513. 
               
               
                 175 
                 8 
                 ESP: 490. 
               
               
                 176 
                 7 
                 ESN: 488. 
               
               
                 177 
                 7 
                 ESP: 514. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 140 
               
               
                   
               
               
                 Pr 
                 PSy 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 178 
                 4 
                 ESP: 371. 
               
               
                 179 
                 3 
                 ESP: 471. 
               
               
                 180 
                 4 
                 ESP: 371. 
               
               
                 181 
                 3 
                 ESP: 471. 
               
               
                 182 
                 2 
                 ESP: 329. 
               
               
                 183 
                 1 
                 FP: 419. 
               
               
                 184 
                 12 
                 EI: 264. 
               
               
                 185 
                 121 
                 NMR1: 2.97-3.01(2H, m), 3.53-3.62(2H, m), 
               
               
                   
                   
                 7.60-7.71(3H, m), 7.96(2H, s), 8.21-8.26(2H, s), 
               
               
                   
                   
                 9.23-9.29(1H, m). 
               
               
                 186 
                 121 
                 ESP: 375. 
               
               
                 187 
                 4 
                 ESP: 349. 
               
               
                 188 
                 3 
                 ESP: 449. 
               
               
                 189 
                 2 
                 NMR2: 1.27(3H, t), 1.38-1.49(2H, m), 
               
               
                   
                   
                 1.58-1.67(2H, m), 1.70-1.79(2H, m), 1.90-2.00(1H, m), 
               
               
                   
                   
                 2.01-2.10(2H, m), 2.56-2.63(1H, m), 3.87(2H, d), 
               
               
                   
                   
                 4.15(2H, m), 6.92(2H, d), 8.04(2H, m). 
               
               
                 190 
                 1 
                 ESP: 397. 
               
               
                 191 
                 7 
                 ESP: 467. 
               
               
                 192 
                 7 
                 ESP: 493. 
               
               
                 193 
                 7 
                 ESP: 481. 
               
               
                 194 
                 7 
                 ESP: 495. 
               
               
                 195 
                 8 
                 ESP: 497. 
               
               
                 196 
                 4 
                 ESP: 349. 
               
               
                 197 
                 3 
                 NMR2: 1.23(3H, s), 1.28(3H, t), 1.44(9H, s), 
               
               
                   
                   
                 1.62-1.80(4H, m), 1.83-1.99(4H, m), 3.38-3.44(2H, m), 
               
               
                   
                   
                 3.52-3.58(2H, m), 4.17(2H, q), 4.46-4.52(1H, m), 
               
               
                   
                   
                 4.95-5.02(1H, m), 6.91(2H, d), 7.01(1H, s), 
               
               
                   
                   
                 7.77(2H, d). 
               
               
                 198 
                 2 
                 ESP: 3 07. 
               
               
                 199 
                 1 
                 NMR2: 1.23(3H, s), 1.27(3H, t), 1.66(2H, tt), 
               
               
                   
                   
                 1.76(2H, tt), 1.84-1.99(4H, m), 4.17(2H, q), 
               
               
                   
                   
                 4.48-4.53(1H, m), 5.34(2H, s), 6.91(2H, d), 
               
               
                   
                   
                 7.32-7.47(5H, m), 8.02(2H, d). 
               
               
                 200 
                 8 
                 ESN: 465. 
               
               
                 201 
                 4 
                 ESP: 319. 
               
               
                 202 
                 123 
                 NMR2: 1.17(2H, q), 1.43(9H, s), 1.52(2H, q), 
               
               
                   
                   
                 1.83-1.95(5H, m), 2.27(2H, d), 2.52(1H, tt), 
               
               
                   
                   
                 3.37-3.44(2H, m), 3.53-3.59(2H, m), 3.69(3H, s), 
               
               
                   
                   
                 4.97(1H, s), 7.05(1H, s), 7.26(2H, d), 7.74(2H, d). 
               
               
                 203 
                 8 
                 ESN: 489. 
               
               
                 204 
                 8 
                 ESN: 489. 
               
               
                 205 
                 8 
                 ESN: 471. 
               
               
                 206 
                 7 
                 ESP: 545. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 141 
               
               
                   
               
               
                 Pr 
                 PSy 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 207 
                 7 
                 ESP: 563. 
               
               
                 208 
                 7 
                 ESP: 497. 
               
               
                 209 
                 7 
                 ESN: 453. 
               
               
                 210 
                 126 
                 ESP: 579. 
               
               
                 211 
                 126 
                 ESP: 579. 
               
               
                 212 
                 7 
                 ESP: 559. 
               
               
                 213 
                 7 
                 ESP: 559. 
               
               
                 214 
                 7 
                 ESP: 481. 
               
               
                 215 
                 2 
                 ESP: 278. 
               
               
                 216 
                 121 
                 ESP: 371. 
               
               
                 217 
                 1 
                 ESP: 385. 
               
               
                 218 
                 7 
                 ESP: 549. 
               
               
                 219 
                 121 
                 NMR1: 2.95-3.07(2H, m), 3.48-3.60(2H, m), 
               
               
                   
                   
                 7.33-7.41(1H, m), 7.82(m, dd), 7.92-8.06(3H, br), 
               
               
                   
                   
                 8.08(1H, dd), 8.13(1H, s), 9.06-9.14(1H, m). 
               
               
                 220 
                 7 
                 ESP: 554. 
               
               
                 221 
                 7 
                 ESP: 540. 
               
               
                 222 
                 7 
                 ESP: 526. 
               
               
                 223 
                 9 
                 ESN: 333. 
               
               
                 224 
                 8 
                 ESP: 507. 
               
               
                 225 
                 121 
                 ESP: 353. 
               
               
                 226 
                 2 
                 ESN: 309. 
               
               
                 227 
                 1 
                 NMR2: 1.38-1.49(2H, m), 1.55-1.69(4H, m), 
               
               
                   
                   
                 1.86-2.07(3H, m), 2.28(2H, d), 3.68(3H, s), 
               
               
                   
                   
                 4.55-4.61(1H, m), 5.36(2H, s), 6.60-6.72(2H, m), 
               
               
                   
                   
                 7.31-7.42(3H, m), 7.43-7.47(2H, m), 7.91(1H, t). 
               
               
                 228 
                 121 
                 ESP: 353. 
               
               
                 229 
                 2 
                 ESN: 309. 
               
               
                 230 
                 1 
                 NMR2: 1.43-1.69(6H, m), 1.85-1.98(1H, m), 
               
               
                   
                   
                 1.98-2.08(2H, m), 2.28(2H, d), 3.67(3H, s), 
               
               
                   
                   
                 4.62-4.67(1H, m), 5.33(2H, s), 6.97(1H, t), 
               
               
                   
                   
                 7.32-7.45(5H, m), 7.74-7.83(2H, m). 
               
               
                 231 
                 121 
                 ESP:371. 
               
               
                 232 
                 128 
                 NMR1: 1.27-1.39(2H, m), 1.45-1.71(4H, m), 
               
               
                   
                   
                 1.78-1.94(3H, m), 2.25(2H, d), 3.59(3H, s), 
               
               
                   
                   
                 4.72-4.82(1H, m), 7.17-7.29(1H, m), 
               
               
                   
                   
                 7.55-7.67(1H, m). 
               
               
                   
                   
                 ESN: 327. 
               
               
                 233 
                 1 
                 NMR2: 1.41-1.72(15H, m), 1.83-1.98(1H, m), 
               
               
                   
                   
                 1.98-2.08(2H, m), 2.28(2H, d), 3.68(3H, s), 
               
               
                   
                   
                 4.55-4.62(1H, m), 6.63-6.71(1H, m), 
               
               
                   
                   
                 7.54-7.63(1H, m). 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 142 
               
               
                   
               
               
                 Pr 
                 PSy 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 234 
                 1 
                 NMR1: 1.24-1.97(9H, m), 2.25(2H, d), 3.58(3H, s), 
               
               
                   
                   
                 4.65-4.73(1H, m), 5.31(2H, s), 7.05(2H, d), 
               
               
                   
                   
                 7.32-7.47(5H, m), 7.92(2H, d). 
               
               
                 235 
                 2 
                 ESN: 291. 
               
               
                 236 
                 121 
                 ESP: 335. 
               
               
                 237 
                 2 
                 NMR1: 1.18(3H, t), 1.36-1.61(4H, m), 
               
               
                   
                   
                 1.90-1.97(2H, m), 2.03-2.09(2H, m), 2.35(1H, tt), 
               
               
                   
                   
                 4.06(2H, q), 4.46(1H, tt), 6.85(1H, dd), 
               
               
                   
                   
                 6.92(1H, dd), 7.78(1H, t). 
               
               
                 238 
                 1 
                 NMR2: 1.26(3H, t), 1.45-1.67(4H, m), 
               
               
                   
                   
                 2.06-2.21(4H, m), 2.35(1H, tt), 4.14(2H, q), 
               
               
                   
                   
                 4.26(1H, tt), 5.35(2H, s), 6.61(1H, dd), 
               
               
                   
                   
                 6.68(1H, dd), 7.30-7.41(3H, m), 7.43-7.47(2H, m), 
               
               
                   
                   
                 7.90(1H, t). 
               
               
                 239 
                 128 
                 ESP: 328. 
               
               
                 240 
                 127 
                 ESP: 384. 
               
               
                 241 
                 128 
                 ESN: 326. 
               
               
                 242 
                 127 
                 ESP: 384. 
               
               
                 243 
                 2 
                 ESN: 327. 
               
               
                 244 
                 1 
                 ESP: 419. 
               
               
                 245 
                 2 
                 NMR1: 1.25-1.97(9H, m), 2.26(2H, d), 3.59(3H, s), 
               
               
                   
                   
                 4.75-4.82(1H, m), 7.09-7.16(1H, m), 
               
               
                   
                   
                 7.60-7.67(1H, m). 
               
               
                 246 
                 1 
                 NMR1: 1.21-1.95(9H, m), 2.25(2H, d), 3.59(3H, s), 
               
               
                   
                   
                 4.77-4.83(1H, m), 5.35(2H, s), 7.14-7.20(1H, m), 
               
               
                   
                   
                 7.32-7.48(5H, m), 7.66-7.73(1H, m). 
               
               
                 247 
                 121 
                 ESP: 255. 
               
               
                 248 
                 2 
                 ESN: 308. 
               
               
                 249 
                 127 
                 ESP: 400. 
               
               
                 250 
                 4 
                 ESP: 371. 
               
               
                 251 
                 3 
                 ESP: 471. 
               
               
                 252 
                 128 
                 ESN: 327. 
               
               
                 253 
                 1 
                 NMR2: 1.27(3H, t), 1.57(9H, s), 1.59-1.80(4H, m), 
               
               
                   
                   
                 1.94-2.10(4H, m), 2.34-2.42(1H, m), 4.16(2H, q), 
               
               
                   
                   
                 4.48-4.54(1H, m), 7.52(2H, d). 
               
               
                 254 
                 2 
                 ESP: 329. 
               
               
                 255 
                 1 
                 ESP: 419 
               
               
                 256 
                 2 
                 ESP: 318. 
               
               
                 257 
                 127 
                 ESP: 408. 
               
               
                 258 
                 128 
                 ESN: 327. 
               
               
                 259 
                 1 
                 NMR2: 1.28(3H, t), 1.52-1.67(14H, m), 
               
               
                   
                   
                 2.07-2.22(3H, m), 2.32-2.41(1H, m), 4.15(2H, q), 
               
               
                   
                   
                 4.21-4.30(1H, m), 6.67(1H, dd), 7.58(1H, dd). 
               
               
                 260 
                 2 
                 ESN: 327. 
               
               
                 261 
                 1 
                 ESP: 419. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 143 
               
               
                   
               
               
                 Pr 
                 PSy 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 262 
                 121 
                 NMR1: 2.92-3.02(2H, m), 3.44-3.53(2H, m), 
               
               
                   
                   
                 7.21(1H, d), 7.85(1H, d), 8.16(2H, s), 
               
               
                   
                   
                 9.03-9.12(1H, m). 
               
               
                 263 
                 24 
                 EI: 23 8. 
               
               
                 264 
                 23 
                 ESP: 267. 
               
               
                 265 
                 21 
                 NMR1: 0.65-0.70(2H, m), 0.93-1.00(2H, m), 
               
               
                   
                   
                 1.86-1.95(1H, m), 6.63(1H, d), 7.34(1H, d). 
               
               
                 266 
                 133 
                 NMR1: 0.72-0.82(2H, m), 1.13-1.21(2H, m), 
               
               
                   
                   
                 2.14-2.23(1H, m), 7.57(1H, s), 12.9-13.7(1H, br). 
               
               
                 267 
                 21 
                 NMR1: 0.62-0.67(2H, m), 1.04-1.10(2H, m), 
               
               
                   
                   
                 2.05-2.13(1H, m), 6.96(1H, d), 7.38(1H, d). 
               
               
                 268 
                 24 
                 ESN: 227. 
               
               
                 269 
                 20 
                 ESN: 175. 
               
               
                 270 
                 20 
                 ESN: 179. 
               
               
                 271 
                 20 
                 ESN: 191. 
               
               
                 272 
                 19 
                 ESN: 205. 
               
               
                 273 
                 18 
                 ESN: 219. 
               
               
                 274 
                 20 
                 ESN: 191. 
               
               
                 275 
                 20 
                 ESN: 205. 
               
               
                 276 
                 20 
                 ESN: 245. 
               
               
                 277 
                 20 
                 ESP: 203. 
               
               
                 278 
                 20 
                 NMR1: 0.77-0.92(2H, m), 1.01-1.14(2H, m), 
               
               
                   
                   
                 2.03-2.15(1H, m), 6.95(1H, dd), 7.54(1H, dd). 
               
               
                 279 
                 20 
                 ESN: 211. 
               
               
                 280 
                 20 
                 ESN: 211. 
               
               
                 281 
                 19 
                 ESN: 225. 
               
               
                 282 
                 22 
                 ESP: 301. 
               
               
                 283 
                 20 
                 ESN: 217. 
               
               
                 284 
                 20 
                 ESN: 195. 
               
               
                 285 
                 20 
                 ESN: 167. 
               
               
                 286 
                 135 
                 ESN: 245. 
               
               
                 287 
                 20 
                 ESN:211. 
               
               
                 288 
                 22 
                 NMR1: 1.57(3H, d), 5.61(1H, q), 6.98(2H, d), 
               
               
                   
                   
                 7.26(1H, t), 7.35(2H, t), 7.41(2H, d), 
               
               
                   
                   
                 7.79(2H, d). 
               
               
                 289 
                 1 
                 NMR2: 1.66(3H, d), 5.30(2H, s), 5.38(2H, q), 
               
               
                   
                   
                 6.86(2H, d), 7.30-7.42(10H, m), 7.93(2H, d). 
               
               
                 290 
                 22 
                 NMR1: 1.57(3H, d), 5.61(1H, q), 6.97(2H, d), 
               
               
                   
                   
                 7.26(1H, t), 7.35(2H, t), 7.41(2H, d), 
               
               
                   
                   
                 7.79(2H, d). 
               
               
                 291 
                 1 
                 NMR2: 1.66(3H, d), 5.30(2H, s), 5.38(2H, q), 
               
               
                   
                   
                 6.87(2H, d), 7.30-7.43(10H, m), 7.93(2H, d). 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 144 
               
               
                   
                   
               
               
                   
                 Pr 
                 PSy 
                 Data 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 292 
                 124 
                 NMR2: 1.42(3H, t), 4.43(2H, q), 7.78(1H, d), 
               
               
                   
                   
                   
                 8.03(1H, d), 8.17(1H, s). 
               
               
                   
                 293 
                 2 
                 ESN: 341. 
               
               
                   
                 294 
                 1 
                 ESP: 433. 
               
               
                   
                 295 
                 12 
                 ESN: 277. 
               
               
                   
                 296 
                 4 
                 ESP: 334. 
               
               
                   
                 297 
                 9 
                 ESP: 434. 
               
               
                   
                 298 
                 9 
                 ESP: 547. 
               
               
                   
                 299 
                 2 
                 ESN: 349. 
               
               
                   
                 300 
                 125 
                 ESN: 325. 
               
               
                   
                 301 
                 1 
                 ESP: 369. 
               
               
                   
                 302 
                 2 
                 ESN: 277. 
               
               
                   
                 303 
                 2 
                 ESN: 263. 
               
               
                   
                 304 
                 1 
                 ESP: 355. 
               
               
                   
                 305 
                 2 
                 ESN: 263. 
               
               
                   
                 306 
                 1 
                 ESP: 355. 
               
               
                   
                 307 
                 9 
                 ESP: 389. 
               
               
                   
                 308 
                 9 
                 ESP: 487. 
               
               
                   
                 309 
                 1 
                 ESP: 291. 
               
               
                   
                 310 
                 1 
                 ESP: 381. 
               
               
                   
                 311 
                 9 
                 ESP: 532. 
               
               
                   
                 312 
                 2 
                 FN: 334. 
               
               
                   
                 313 
                 1 
                 ESP: 426. 
               
               
                   
                 314 
                 9 
                 ESP: 475. 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 145 
               
               
                   
                   
               
               
                   
                 Ex 
                 Syn 
                 Data 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 1 
                 1 
                 ESN: 409. 
               
               
                   
                 2 
                 2 
                 ESP: 466. 
               
               
                   
                 3 
                 3 
                 ESP: 451. 
               
               
                   
                 4 
                 4 
                 ESP: 515. 
               
               
                   
                 5 
                 5 
                 ESN: 493. 
               
               
                   
                 6 
                 6 
                 ESP: 443. 
               
               
                   
                 7 
                 1 
                 ESP: 522. 
               
               
                   
                 8 
                 8 
                 ESP: 444. 
               
               
                   
                 9 
                 9 
                 ESP: 469. 
               
               
                   
                 10 
                 1 
                 ESN: 424. 
               
               
                   
                 11 
                 1 
                 ESN: 409. 
               
               
                   
                 12 
                 1 
                 ESP: 493. 
               
               
                   
                 13 
                 1 
                 ESN: 443. 
               
               
                   
                 14 
                 1 
                 ESP: 411. 
               
               
                   
                 15 
                 1 
                 NMR1: 1.62-1.86(8H, m), 2.32-2.44(1H, m), 
               
               
                   
                   
                   
                 3.39-3.43(4H, m), 4.59-4.65(1H, m), 6.99(2H, d), 
               
               
                   
                   
                   
                 7.54(2H, d), 7.79(2H, d), 7.86(2H, d), 
               
               
                   
                   
                   
                 8.43-8.48(1H, m), 8.66-8.72(1H, m). 
               
               
                   
                   
                   
                 ESN: 443. 
               
               
                   
                 16 
                 1 
                 ESP: 527. 
               
               
                   
                 17 
                 1 
                 ESP: 527. 
               
               
                   
                 18 
                 1 
                 NMR1: 1.33(3H, t), 1.55-1.70(4H, m), 
               
               
                   
                   
                   
                 1.75-1.86(4H, m), 2.16-2.23(1H, m), 
               
               
                   
                   
                   
                 3.38-3.42(4H, m), 4.06(2H, q), 
               
               
                   
                   
                   
                 4.54-4.60(1H, m), 6.94(2H, d), 6.99(2H, d), 
               
               
                   
                   
                   
                 7.82-7.87(4H, m), 8.80-8.90(2H, m). 
               
               
                   
                   
                   
                 ESP: 455. 
               
               
                   
                 19 
                 1 
                 ESP: 455. 
               
               
                   
                 20 
                 1 
                 ESP: 513. 
               
               
                   
                 21 
                 1 
                 ESP: 445. 
               
               
                   
                 22 
                 1 
                 ESP: 445. 
               
               
                   
                 23 
                 1 
                 ESP: 499. 
               
               
                   
                 24 
                 1 
                 ESP: 527. 
               
               
                   
                 25 
                 1 
                 ESP: 527. 
               
               
                   
                 26 
                 1 
                 ESP: 429. 
               
               
                   
                 27 
                 1 
                 ESP: 451. 
               
               
                   
                 28 
                 1 
                 ESP: 494. 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 146 
               
               
                   
               
               
                 Ex 
                 Syn 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 29 
                 1 
                 NMR1: 1.62-1.83(8H, m), 2.34-2.41(1H, m), 
               
               
                   
                   
                 3.40-3.43(4H, m), 4.60-4.65(1H, m), 6.85(1H, dd), 
               
               
                   
                   
                 6.90(1H, dd), 7.54(2H, d), 7.61(1H, t), 
               
               
                   
                   
                 7.86(2H, d), 8.16-8.20(1H, m), 8-63-8.68(1H, m). 
               
               
                   
                   
                 ESP: 463. 
               
               
                 30 
                 1 
                 ESP: 463. 
               
               
                 31 
                 2 
                 ESP: 460. 
               
               
                 32 
                 5 
                 ESN: 492. 
               
               
                 33 
                 3 
                 ESP: 425. 
               
               
                 34 
                 3 
                 ESP: 469. 
               
               
                 35 
                 3 
                 ESP: 503. 
               
               
                 36 
                 3 
                 ESP: 475. 
               
               
                 37 
                 3 
                 ESP: 463. 
               
               
                 38 
                 1 
                 ESN: 415. 
               
               
                 39 
                 1 
                 ESN: 415. 
               
               
                 40 
                 1 
                 ESN: 449. 
               
               
                 41 
                 1 
                 NMR1: 1.62-1.85(8H, m), 2.34-2.42(1H, m), 
               
               
                   
                   
                 3.42-3.45(4H, m), 4.60-4.65(1H, m), 6.99(2H, d), 
               
               
                   
                   
                 7.80(2H, d), 7.86(2H, d), 8.04(2H, d), 
               
               
                   
                   
                 8.44-8.49(1H, m), 8.82-8.86(1H, m). 
               
               
                   
                   
                 ESP: 479. 
               
               
                 42 
                 1 
                 ESP: 417. 
               
               
                 43 
                 1 
                 ESP: 441. 
               
               
                 44 
                 1 
                 ESP: 429. 
               
               
                 45 
                 1 
                 NMR1: 1.62-1.85(8H, m), 2.34-2.41(1H, m), 
               
               
                   
                   
                 3.39-3.45(4H, m), 4.60-4.65(1H, m), 7.00(2H, d), 
               
               
                   
                   
                 7.47(2H, d), 7.80(2H, d), 7.97(2H, d), 
               
               
                   
                   
                 8.43-8.47(1H, m), 8.70-8.74(1H, m). 
               
               
                   
                   
                 ESP: 495. 
               
               
                 46 
                 1 
                 ESP: 527. 
               
               
                 47 
                 3 
                 ESP: 441. 
               
               
                 48 
                 3 
                 ESP: 445. 
               
               
                 49 
                 3 
                 ESP: 450. 
               
               
                 50 
                 3 
                 ESP: 450. 
               
               
                 51 
                 5 
                 ESN: 450. 
               
               
                 52 
                 3 
                 ESN: 463. 
               
               
                 53 
                 3 
                 ESP: 467. 
               
               
                 54 
                 3 
                 ESP: 481. 
               
               
                 55 
                 3 
                 ESP: 525. 
               
               
                 56 
                 2 
                 ESP: 460. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 147 
               
               
                   
                   
               
               
                   
                 Ex 
                 Syn 
                 Data 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 57 
                 2 
                 ESP: 460. 
               
               
                   
                 58 
                 3 
                 ESP: 503. 
               
               
                   
                 59 
                 3 
                 ESP: 441. 
               
               
                   
                 60 
                 3 
                 ESP: 427. 
               
               
                   
                 61 
                 3 
                 ESP: 446. 
               
               
                   
                 62 
                 3 
                 ESP: 446. 
               
               
                   
                 63 
                 3 
                 ESP: 521. 
               
               
                   
                 64 
                 1 
                 NMR1: 1.73(3H, t), 1.62-1.84(8H, m), 
               
               
                   
                   
                   
                 2.35-2.42(1H, m), 3.37-3.42(4H, m), 4.18(2H, q), 
               
               
                   
                   
                   
                 4.60-4.65(1H, m), 6.99(2H, d), 7.21(1H, d), 
               
               
                   
                   
                   
                 7.80(2H, d), 7.82(1H, dd), 7.93(1H, d), 
               
               
                   
                   
                   
                 8.42-8.47(1H, m), 8.55-8.59(1H, m). 
               
               
                   
                   
                   
                 ESP: 489. 
               
               
                   
                 65 
                 1 
                 ESP: 489. 
               
               
                   
                 66 
                 1 
                 ESP: 479. 
               
               
                   
                 67 
                 1 
                 NMR1: 1.62-1.84(8H, m), 2.34-2.41(1H, m), 
               
               
                   
                   
                   
                 3.39-3.43(4H, m), 4.60-4.65(1H, m), 7.00(2H, d), 
               
               
                   
                   
                   
                 7.74-7.84(4H, m), 8.07(1H, d), 8.43-8.47(1H, m), 
               
               
                   
                   
                   
                 8.77-8.82(1H, m). 
               
               
                   
                   
                   
                 ESP: 479. 
               
               
                   
                 68 
                 3 
                 ESP: 451. 
               
               
                   
                 69 
                 3 
                 ESP: 455. 
               
               
                   
                 70 
                 3 
                 ESP: 519. 
               
               
                   
                 71 
                 3 
                 ESP: 447. 
               
               
                   
                 72 
                 3 
                 ESP: 459. 
               
               
                   
                 73 
                 3 
                 ESP: 459. 
               
               
                   
                 74 
                 3 
                 ESP: 485. 
               
               
                   
                 75 
                 3 
                 ESP: 513. 
               
               
                   
                 76 
                 3 
                 ESP: 428. 
               
               
                   
                 77 
                 3 
                 ESP: 475. 
               
               
                   
                 78 
                 3 
                 ESP: 475. 
               
               
                   
                 79 
                 1 
                 NMR1: 0.68-0.74(2H, m), 0.95-1.01(2H, m), 
               
               
                   
                   
                   
                 1.50-1.70(4H, m), 1.74-1.90(4H, m), 1.95(1H, tt), 
               
               
                   
                   
                   
                 2.05-2.11(1H, m), 3.42-3.48(4H, m), 
               
               
                   
                   
                   
                 4.51-4.56(1H, m), 7.00(2H, d), 7.10(2H, d), 
               
               
                   
                   
                   
                 7.79(2H, d), 7.87(2H, d), 9.04-9.28(2H, m). 
               
               
                   
                   
                   
                 ESP: 451. 
               
               
                   
                 80 
                 1 
                 ESP: 475. 
               
               
                   
                 81 
                 1 
                 ESP: 487. 
               
               
                   
                 82 
                 1 
                 ESP: 497. 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 148 
               
               
                   
               
               
                 Ex 
                 Syn 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 83 
                 1 
                 NMR1: 1.54-1.72(4H, m), 1.75-1.88(4H, m), 
               
               
                   
                   
                 2.15-2.23(1H, m), 3.45-3.54(4H, m), 
               
               
                   
                   
                 4.54-4.59(1H, m), 7.01(2H, d), 7.55-7.62(2H, m), 
               
               
                   
                   
                 7.87(2H, d), 7.94-8.01(4H, m), 8.51(1H, s), 
               
               
                   
                   
                 8.91-8.99(1H, m), 9.28-9.38(1H, m). 
               
               
                   
                   
                 ESP 461. 
               
               
                 84 
                 1 
                 ESN: 459. 
               
               
                 85 
                 3 
                 ESP: 446. 
               
               
                 86 
                 3 
                 ESP: 446. 
               
               
                 87 
                 3 
                 ESP: 446. 
               
               
                 88 
                 3 
                 ESP: 446. 
               
               
                 89 
                 3 
                 ESP: 561. 
               
               
                 90 
                 3 
                 ESP: 553. 
               
               
                 91 
                 3 
                 ESP: 453. 
               
               
                 92 
                 3 
                 NMR1: 1.59-1.86(8H, m), 2.30-2.45(1H, m), 
               
               
                   
                   
                 3.22-3.48(4H, m), 4.59-4.68(1H, m), 6.99(2H, d), 
               
               
                   
                   
                 7.25(2H, d), 7.34(1H, t), 7.79(2H, d), 
               
               
                   
                   
                 7.91(2H, d), 8.41-8.48(1H, m), 8.60-8.66(1H, m), 
               
               
                   
                   
                 12.02-12.27(1H, m). 
               
               
                   
                   
                 ESP: 477. 
               
               
                 93 
                 3 
                 ESP: 467. 
               
               
                 94 
                 3 
                 ESP: 511. 
               
               
                 95 
                 3 
                 ESP: 455. 
               
               
                 96 
                 3 
                 ESP: 451. 
               
               
                 97 
                 7 
                 ESP: 551. 
               
               
                 98 
                 1 
                 ESP: 446. 
               
               
                 99 
                 1 
                 ESP: 446. 
               
               
                 100 
                 3 
                 ESP: 525. 
               
               
                 101 
                 3 
                 ESP: 528. 
               
               
                 102 
                 3 
                 ESP: 533. 
               
               
                 103 
                 1 
                 NMR1: 1.55-1.86(8H, m), 2.29(3H, s), 
               
               
                   
                   
                 2.30-2.42(1H, m), 3.20-3.53(4H, m), 
               
               
                   
                   
                 4.53-4.64(1H, m), 6.74-6.84(2H, m), 7.31(1H, d), 
               
               
                   
                   
                 7.55(2H, d), 7.87(2H, d), 8.15-8.24(1H, m), 
               
               
                   
                   
                 8.57-8.68(1H, m), 12.02-12.30(1H, bs). 
               
               
                   
                   
                 ESP: 459. 
               
               
                 104 
                 3 
                 ESP: 495. 
               
               
                 105 
                 3 
                 ESP: 463. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 149 
               
               
                   
               
               
                 Ex 
                 Syn 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 106 
                 3 
                 NMR1: 1.59-1.88(8H, m), 2.30-2.44(4H, m), 
               
               
                   
                   
                 3.36-3.47(4H, m), 4.58-4.67(1H, m), 7.01(2H, d), 
               
               
                   
                   
                 7.47-7.55(1H, m), 7.64-7.72(1H, m), 
               
               
                   
                   
                 7.75-7.88(3H, m), 8.40-8.50(1H, m), 
               
               
                   
                   
                 8.59-8.70(1H, m), 12.02-12.30(1H, bs). 
               
               
                   
                   
                 ESP: 459. 
               
               
                 107 
                 3 
                 ESP: 425. 
               
               
                 108 
                 3 
                 NMR1: 1.60-1.84(8H, m), 2.32-2.42(1H, m), 
               
               
                   
                   
                 3.38-3.44(4H, m), 4.60-4.64(1H, m), 7.00(2H, d), 
               
               
                   
                   
                 7.77-7.87(5H, m), 8.42-8.44(1H, m), 
               
               
                   
                   
                 8.80-8.84(1H, m). 
               
               
                   
                   
                 ESP: 479. 
               
               
                 109 
                 3 
                 ESP: 465. 
               
               
                 110 
                 3 
                 NMR1: 1.58-1.86(8H, m), 2.30-2.45(1H, m), 
               
               
                   
                   
                 3.22-3.48(4H, m), 4.58-4.66(1H, m), 6.99(2H, d), 
               
               
                   
                   
                 7.54(1H, d), 7.62(1H, t), 7.76-7.83(3H, d), 
               
               
                   
                   
                 7.88(1H, d), 8.43-8.49(1H, m), 8.75-8.81(1H, m), 
               
               
                   
                   
                 12.02-12.27(1H, m). 
               
               
                   
                   
                 ESP: 495. 
               
               
                 111 
                 2 
                 ESP: 510. 
               
               
                 112 
                 2 
                 ESP: 494. 
               
               
                 113 
                 1 
                 ESP: 459. 
               
               
                 114 
                 3 
                 ESN: 505. 
               
               
                 115 
                 3 
                 ESP: 515. 
               
               
                 116 
                 3 
                 ESP: 509. 
               
               
                 117 
                 3 
                 ESP: 455. 
               
               
                 118 
                 3 
                 NMR1: 1.58-1.86(12H, m), 2.01-2.16(2H, m), 
               
               
                   
                   
                 2.30-2.45(1H, m), 2.63-2.81(1H, m), 
               
               
                   
                   
                 3.22-3.48(4H, m), 4.00(2H, d), 4.58-4.65(1H, m), 
               
               
                   
                   
                 6.94-7.02(4H, m), 7.77-7.83(4H, m), 
               
               
                   
                   
                 8.40-8.48(2H, m), 12.02-12.27(1H, m). 
               
               
                   
                   
                 ESP: 495. 
               
               
                 119 
                 3 
                 NMR1: 1.35(3H, t), 1.61-1.85(8H, m), 
               
               
                   
                   
                 2.31-2.43(1H, m), 3.22-3.48(4H, m), 4.16(2H, q), 
               
               
                   
                   
                 4.59-4.65(1H, m), 6.99(2H, d), 7.23(1H, t), 
               
               
                   
                   
                 7.65-7.71(2H, m), 7.79(2H, d), 8.42-8.47(1H, m), 
               
               
                   
                   
                 8.51-8.57(1H, m), 12.01-12.32(1H, m). 
               
               
                   
                   
                 ESP: 473. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 150 
               
               
                   
               
               
                 Ex 
                 Syn 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 120 
                 3 
                 NMR1: 0.31-0.38(2H, m), 0.55-0.61(2H, m), 
               
               
                   
                   
                 1.19-1.30(1H, m), 1.61-1.85(8H, m), 
               
               
                   
                   
                 2.31-2.43(1H, m), 3.22-3.45(4H, m), 3.95(2H, d), 
               
               
                   
                   
                 4.59-4.65(1H, m), 6.99(2H, d), 7.20(1H, d), 
               
               
                   
                   
                 7.63-7.72(2H, m), 7.79(2H, d), 8.42-8.49(1H, m), 
               
               
                   
                   
                 8.51-8.59(1H, m), 12.01-12.36(1H, m). 
               
               
                   
                   
                 ESP: 499. 
               
               
                 121 
                 3 
                 NMR1: 0.31-0.38(2H, m), 0.55-0.61(2H, m), 
               
               
                   
                   
                 1.19-1.30(1H, m), 1.61-1.85(8H, m), 
               
               
                   
                   
                 2.31-2.43(1H, m), 3.22-3.45(4H, m), 3.95(2H, d), 
               
               
                   
                   
                 4.59-4.65(1H, m), 6.99(2H, d), 7.18(1H, d), 
               
               
                   
                   
                 7.76-7.84(3H, m), 7.93(1H, d), 8.43-8.49(1H, m), 
               
               
                   
                   
                 8.56-8.62(1H, m). 
               
               
                   
                   
                 ESP: 515. 
               
               
                 122 
                 3 
                 ESP: 499. 
               
               
                 123 
                 3 
                 ESP: 480. 
               
               
                 124 
                 3 
                 ESP: 484. 
               
               
                 125 
                 1 
                 NMR1: 1.62-1.85(8H, m), 2.34-2.42(1H, m), 
               
               
                   
                   
                 3.40-3.44(4H, m), 4.60-4.64(1H, m), 6.99(2H, d), 
               
               
                   
                   
                 7.71(1H, t), 7.77-7.82(3H, m), 7.92(1H, d), 
               
               
                   
                   
                 8.43-8.47(1H, m), 8.78-8.83(1H, m). 
               
               
                   
                   
                 ESN: 511. 
               
               
                 126 
                 1 
                 NMR1: 1.62-1.85(8H, m), 2.34-2.42(1H, m), 
               
               
                   
                   
                 3.40-3.44(4H, m), 4.60-4.64(1H, m), 6.99(2H, d), 
               
               
                   
                   
                 7.70(1H, dd), 7.79(2H, d), 7.93(1H, dd), 
               
               
                   
                   
                 8.12(1H, d), 8.43-8.48(1H, m), 8.80-8.85(1H, m). 
               
               
                   
                   
                 ESN: 527. 
               
               
                 127 
                 1 
                 ESN: 495. 
               
               
                 128 
                 3 
                 ESP: 497. 
               
               
                 129 
                 3 
                 NMR1: 1.62-1.83(8H, m), 2.31-2.43(1H, m), 
               
               
                   
                   
                 3.42-3.48(4H, m), 4.64-4.73(1H, m), 7.28(1H, t), 
               
               
                   
                   
                 7.62-7.72(2H, m), 7.93-8.03(2H, m), 8.11(1H, s), 
               
               
                   
                   
                 8.53-8.58(1H, m), 8.91-8.96(1H, m), 
               
               
                   
                   
                 12.11-12.23(1H, m). 
               
               
                   
                   
                 ESP: 531. 
               
               
                 130 
                 4 
                 ESP: 513. 
               
               
                 131 
                 3 
                 ESP: 531. 
               
               
                 132 
                 3 
                 NMR1: 1.62-1.83(8H, m), 2.31-2.43(1H, m), 
               
               
                   
                   
                 3.42-3.48(4H, m), 4.65-4.70(1H, m), 7.28(1H, t), 
               
               
                   
                   
                 7.60-7.72(3H, m), 7.92(1H, dd), 8.11(1H, d), 
               
               
                   
                   
                 8.51-8.58(1H, m), 8.79-8.86(1H, m), 
               
               
                   
                   
                 12.07-12.23(1H, m). 
               
               
                   
                   
                 ESP: 547. 
               
               
                 133 
                 3 
                 ESP: 469. 
               
               
                 134 
                 3 
                 ESP: 487. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 151 
               
               
                   
               
               
                 Ex 
                 Syn 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 135 
                 3 
                 NMR1: 0.73-0.80(2H, m), 1.02-1.09(2H, m), 
               
               
                   
                   
                 1.63-1.87(8H, m), 2.14-2.25(1H, m), 
               
               
                   
                   
                 2.31-2.42(1H, m), 3.28-3.43(4H, m), 
               
               
                   
                   
                 4.64-4.71(1H, m), 7.09(1H, d), 7.28(1H, t), 
               
               
                   
                   
                 7.62-7.72(3H, m), 7.88(1H, s), 8.51-8.57(1H, m), 
               
               
                   
                   
                 8.61-8.68(1H, m), 12.05-12.23(1H, m). 
               
               
                   
                   
                 ESP: 503. 
               
               
                 136 
                 3 
                 ESP: 491. 
               
               
                 137 
                 3 
                 NMR1: 1.37(3H, t), 1.63-1.86(8H, m), 
               
               
                   
                   
                 2.31-2.43(1H, m), 3.41-3.45(4H, m), 4.18(2H, q), 
               
               
                   
                   
                 4.63-4.71(1H, m), 7.21(1H, d), 7.28(1H, t), 
               
               
                   
                   
                 7.61-7.72(2H, m), 7.81(1H, dd), 7.93(1H, d), 
               
               
                   
                   
                 8.51-8.62(2H, m), 12.01-12.37(1H, m). 
               
               
                   
                   
                 ESP: 507./509. 
               
               
                 138 
                 3 
                 NMR1: 1.62-1.83(8H, m), 2.31-2.43(1H, m), 
               
               
                   
                   
                 3.42-3.48(4H, m), 4.63-4.73(1H, m), 7.28(1H, t), 
               
               
                   
                   
                 7.62-7.85(4H, m), 8.07(1H, s), 8.49-8.58(1H, m), 
               
               
                   
                   
                 8.73-8.83(1H, m), 12.07-12.24(1H, m). 
               
               
                   
                   
                 ESP: 497./499. 
               
               
                 139 
                 3 
                 ESP: 469. 
               
               
                 140 
                 3 
                 ESP: 499. 
               
               
                 141 
                 3 
                 ESP: 517. 
               
               
                 142 
                 3 
                 NMR1: 0.33-0.38(2H, m), 0.56-0.63(2H, m), 
               
               
                   
                   
                 1.19-1.31(1H, m), 1.61-1.87(8H, m), 
               
               
                   
                   
                 2.31-2.43(1H, m), 3.22-3.45(4H, m), 3.98(2H, d), 
               
               
                   
                   
                 4.65-4.70(1H, m), 7.19(1H, d), 7.28(1H, t), 
               
               
                   
                   
                 7.61-7.72(2H, m), 7.79(1H, dd), 7.93(1H, d), 
               
               
                   
                   
                 8.51-8.61(2H, m). 
               
               
                   
                   
                 ESP: 533. 
               
               
                 143 
                 3 
                 ESP: 477. 
               
               
                 144 
                 3 
                 ESP: 529. 
               
               
                 145 
                 1 
                 NMR1: 1.59-1.85(8H, m), 2.27-2.36(1H, m), 
               
               
                   
                   
                 2.37(3H, s), 3.39-3.43(4H, m), 4.57-4.63(1H, m), 
               
               
                   
                   
                 7.00(2H, d), 7.44(1H, d), 7.73(1H, d), 7.81(2H, d), 
               
               
                   
                   
                 7.90(1H, s), 8.53-8.63(1H, m), 8.78-8.88(1H, m). 
               
               
                   
                   
                 ESP: 459. 
               
               
                 146 
                 1 
                 NMR1: 0.74-0.79(2H, m), 1.02-1.09(2H, m), 
               
               
                   
                   
                 1.62-1.85(8H, m), 2.19(1H, tt), 3.33-2.42(1H, m), 
               
               
                   
                   
                 3.38-3.42(4H, m), 4.60-4.65(1H, m), 6.99(2H, d), 
               
               
                   
                   
                 7.09(1H, d), 7.71(1H, d), 7.79(2H, d), 7.88(1H, s), 
               
               
                   
                   
                 8.41-8.46(1H, m), 8.62-8.67(1H, m). 
               
               
                   
                   
                 ESP: 485. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 152 
               
               
                   
               
               
                 Ex 
                 Syn 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 147 
                 1 
                 NMR1: 1.62-1.85(8H, m), 2.34-2.42(1H, m), 
               
               
                   
                   
                 3.41-3.46(4H, m), 4.60-4.65(1H, m), 7.00(2H, d), 
               
               
                   
                   
                 7.80(2H, d), 7.94-8.02(2H, m), 8.12(1H, s), 
               
               
                   
                   
                 8.43-8.48(1H, m), 8.91-8.95(1H, m). 
               
               
                   
                   
                 ESP: 513. 
               
               
                 148 
                 3 
                 ESP: 534. 
               
               
                 149 
                 1 
                 ESP: 475. 
               
               
                 150 
                 3 
                 ESP: 518. 
               
               
                 151 
                 3 
                 NMR1: 1.60-1.97(12H, m), 2.01-2.16(2H, m), 
               
               
                   
                   
                 2.31-2.42(1H, m), 2.63-2.79(1H, m), 3.22-3.48(4H, m), 
               
               
                   
                   
                 4.10(2H, d), 4.58-4.65(1H, m), 6.99(2H, d), 
               
               
                   
                   
                 7.22(1H, d), 7.76-7.84(3H, m), 7.92(1H, d), 
               
               
                   
                   
                 8.41-8.48(1H, m), 8.51-8.60(1H, m), 
               
               
                   
                   
                 12.02-12.37(1H, m). 
               
               
                   
                   
                 ESP: 529. 
               
               
                 152 
                 3 
                 NMR1: 0.76-0.81(2H, m), 0.99-1.06(2H, m), 
               
               
                   
                   
                 1.61-1.85(8H, m), 2.04-2.11(1H, m), 2.31-2.43(1H, m), 
               
               
                   
                   
                 3.22-3.45(4H, m), 4.59-4.65(1H, m), 6.99(2H, d), 
               
               
                   
                   
                 7.06(1H, t), 7.55-7.62(2H, m), 7.79(2H, d), 
               
               
                   
                   
                 8.41-8.49(1H, m), 8.57-8.62(1H, m), 
               
               
                   
                   
                 12.02-12.27(1H, m). 
               
               
                   
                   
                 ESP: 469. 
               
               
                 153 
                 3 
                 ESP: 469. 
               
               
                 154 
                 1 
                 NMR1: 1.58-1.84(8H, m), 2.29-2.44(1H, m), 
               
               
                   
                   
                 3.30-3.50(4H, m), 4.59-4.68(1H, m), 6.92-7.00(1H, m), 
               
               
                   
                   
                 7.03-7.10(1H, m), 7.40(1H, d), 7.56(2H, d), 
               
               
                   
                   
                 7.87(2H, d), 8.36-8.45(1H, m), 8.58-8.66(1H, m). 
               
               
                   
                   
                 ESN: 477. 
               
               
                 155 
                 1 
                 ESN: 477. 
               
               
                 156 
                 3 
                 NMR1: 1.62-1.85(8H, m), 2.31-2.45(1H, m), 
               
               
                   
                   
                 3.42-3.45(4H, m), 4.59-4.65(1H, m), 6.82-6.94(2H, m), 
               
               
                   
                   
                 7.62(1H, t), 7.86(2H, d), 8.03(2H, d), 
               
               
                   
                   
                 8.15-8.22(1H, m), 8.36-8.53(1H, m), 
               
               
                   
                   
                 12.00-12.31(1H, m). 
               
               
                   
                   
                 ESN: 495. 
               
               
                 157 
                 4 
                 NMR1: 1.62-1.85(8H, m), 2.31-2.45(1H, m), 
               
               
                   
                   
                 3.42-3.45(4H, m), 4.59-4.65(1H, m), 6.82-6.95(2H, m), 
               
               
                   
                   
                 7.61(1H, t), 7.82-7.97(3H, m), 8.15-8.22(1H, m), 
               
               
                   
                   
                 8.84-8.90(1H, m), 12.00-12.31(1H, m). 
               
               
                   
                   
                 ESP: 515. 
               
               
                 158 
                 3 
                 NMR1: 1.62-1.83(8H, m), 2.31-2.43(1H, m), 
               
               
                   
                   
                 3.42-3.48(4H, m), 4.59-4.66(1H, m), 6.80-6.93(2H, m), 
               
               
                   
                   
                 7.61(1H, t), 7.93-8.02(3H, m), 8.11(1H, s), 
               
               
                   
                   
                 8.15-8.22(1H, m), 8.87-8.93(1H, m). 
               
               
                   
                   
                 ESP: 531. 
               
               
                 159 
                 3 
                 NMR1: 1.61-1.85(8H, m), 2.31-2.45(1H, m), 
               
               
                   
                   
                 3.41-3.45(4H, m), 4.59-4.65(1H, m), 6.81-6.94(2H, m), 
               
               
                   
                   
                 7.61(1H, t), 7.71(1H, t), 7.80(1H, d), 7.92(1H, dd), 
               
               
                   
                   
                 8.15-8.21(1H, m), 8.72-8.79(1H, m), 
               
               
                   
                   
                 12.04-12.32(1H, m). 
               
               
                   
                   
                 ESP: 531. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 153 
               
               
                   
               
               
                 Ex 
                 Syn 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 160 
                 3 
                 NMR1: 1.62-1.83(8H, m), 2.31-2.43(1H, m), 
               
               
                   
                   
                 3.42-3.48(4H, m), 4.59-4.66(1H, m), 6.81-6.94(2H, m), 
               
               
                   
                   
                 7.61(1H, t), 7.70(1H, d), 7.92(1H, dd), 8.11(1H, d), 
               
               
                   
                   
                 8.15-8.22(1H, m), 8.87-8.93(1H, m), 12.03-12.22(1H, m). 
               
               
                   
                   
                 ESP: 547. 
               
               
                 161 
                 3 
                 NMR1: 0.75-0.81(2H, m), 0.99-1.06(2H, m), 
               
               
                   
                   
                 1.61-1.85(8H, m), 2.04-2.13(1H, m), 2.31-2.42(1H, m), 
               
               
                   
                   
                 3.28-3.45(4H, m), 4.59-4.67(1H, m), 6.83-6.93(2H, m), 
               
               
                   
                   
                 7.06(1H, t), 7.54-7.64(3H, m), 8.11-8.20(1H, m), 
               
               
                   
                   
                 8.53-8.59(1H, m), 12.06-12.25(1H, m). 
               
               
                   
                   
                 ESP: 487. 
               
               
                 162 
                 3 
                 NMR1: 0.75-0.79(2H, m), 1.02-1.09(2H, m), 
               
               
                   
                   
                 1.61-1.84(8H, m), 2.15-2.25(1H, m), 2.31-2.42(1H, m), 
               
               
                   
                   
                 3.28-3.45(4H, m), 4.60-4.67(1H, m), 6.83-6.93(2H, m), 
               
               
                   
                   
                 7.09(1H, d), 7.61(1H, t), 7.70(1H, dd), 7.87(1H, d), 
               
               
                   
                   
                 8.13-8.20(1H, m), 8.58-8.64(1H, m), 
               
               
                   
                   
                 12.10-12.23(1H, m). 
               
               
                   
                   
                 ESP: 503. 
               
               
                 163 
                 3 
                 NMR1: 1.36(3H, t), 1.61-1.85(8H, m), 2.31-2.45(1H, m), 
               
               
                   
                   
                 3.41-3.45(4H, m), 4.16(2H, q), 4.58-4.65(1H, m), 
               
               
                   
                   
                 6.80-6.95(2H, m), 7.23(1H, t), 7.61(1H, d), 
               
               
                   
                   
                 7.64-7.73(2H, m), 8.12-8.21(1H, m), 8.46-8.58(1H, m), 
               
               
                   
                   
                 12.01-12.27(1H, m). 
               
               
                   
                   
                 ESP: 491. 
               
               
                 164 
                 3 
                 NMR1: 1.36(3H, t), 1.61-1.85(8H, m), 2.31-2.45(1H, m), 
               
               
                   
                   
                 3.41-3.45(4H, m), 4.17(2H, q), 4.58-4.65(1H, m), 
               
               
                   
                   
                 6.82-6.95(2H, m), 7.21(1H, d), 7.61(1H, d), 
               
               
                   
                   
                 7.80(1H, d), 7.92(1H, s), 8.12-8.21(1H, m), 
               
               
                   
                   
                 8.49-8.58(1H, m), 12.07-12.25(1H, m). 
               
               
                   
                   
                 ESP: 507. 
               
               
                 165 
                 3 
                 NMR1: 1.61-1.85(8H, m), 2.31-2.45(1H, m), 
               
               
                   
                   
                 3.41-3.45(4H, m), 4.58-4.65(1H, m), 6.82-6.94(2H, m) 
               
               
                   
                   
                 7.61(1H, d), 7.76(1H, d), 7.81(1H, dd), 8.07(1H, d), 
               
               
                   
                   
                 8.14-8.21(1H, m), 8.72-8.78(1H, m), 12.04-12.25(1H, m). 
               
               
                   
                   
                 ESP: 497, 499. 
               
               
                 166 
                 3 
                 ESP: 513. 
               
               
                 167 
                 3 
                 NMR1: 1.62-1.85(8H, m), 2.31-2.45(1H, m), 
               
               
                   
                   
                 3.42-3.45(4H, m), 4.58-4.66(1H, m), 6.82-6.94(2H, m), 
               
               
                   
                   
                 7.24(2H, d), 7.35(1H, d), 7.61(1H, t), 7.90(2H, d), 
               
               
                   
                   
                 8.13-8.22(1H, m), 8.56-8.63(1H, m), 12.00-12.35(1H, m). 
               
               
                   
                   
                 ESP: 495. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 154 
               
               
                   
               
               
                 Ex 
                 Syn 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 168 
                 3 
                 ESP: 469. 
               
               
                 169 
                 4 
                 NMR1: 1.62-1.85(8H, m), 2.31-2.45(1H, m), 
               
               
                   
                   
                 3.42-3.54(4H, m), 4.60-4.67(1H, m), 6.83-6.94(2H, m), 
               
               
                   
                   
                 7.56-7.67(3H, m), 7.91-8.04(4H, m), 8.17-8.24(1H, m), 
               
               
                   
                   
                 8.44(1H, s), 8.72-8.77(1H, m), 12.00-12.27(1H, br). 
               
               
                   
                   
                 ESP 479. 
               
               
                 170 
                 3 
                 ESP: 533. 
               
               
                 171 
                 3 
                 ESP: 517. 
               
               
                 172 
                 3 
                 ESP: 531. 
               
               
                 173 
                 3 
                 ESP: 547. 
               
               
                 174 
                 1 
                 ESP: 493. 
               
               
                 175 
                 1 
                 ESP: 493. 
               
               
                 176 
                 1 
                 ESP: 493. 
               
               
                 177 
                 3 
                 ESP: 462. 
               
               
                 178 
                 3 
                 ESP: 462. 
               
               
                 179 
                 3 
                 NMR1: 1.60-1.97(12H, m), 2.01-2.13(2H, m), 
               
               
                   
                   
                 2.31-2.42(1H, m), 2.63-2.79(1H, m), 3.22-3.48(4H, m), 
               
               
                   
                   
                 4.0(2H, d), 4.58-4.65(1H, m), 6.99(2H, d), 7.24(1H, d), 
               
               
                   
                   
                 7.64-7.70(2H, m), 7.79(2H, d), 8.42-8.49(1H, m), 
               
               
                   
                   
                 8.51-8.57(1H, m), 12.01-12.32(1H, m). 
               
               
                   
                   
                 ESP: 513. 
               
               
                 180 
                 3 
                 ESP: 513. 
               
               
                 181 
                 3 
                 ESP: 535. 
               
               
                 182 
                 3 
                 ESP: 527. 
               
               
                 183 
                 1 
                 NMR1: 1.33(3H, t), 1.60-1.84(8H, m), 2.30(3H, s), 
               
               
                   
                   
                 2.32-2.40(1H, m), 3.34-3.41(4H, m), 4.07(2H, q), 
               
               
                   
                   
                 4.54-4.60(1H, m), 6.75-6.80(2H, m), 6.97(2H, d), 
               
               
                   
                   
                 7.30(1H, d), 7.80(2H, d), 8.15-8.20(1H, m), 
               
               
                   
                   
                 8.36-8.41(1H, m). 
               
               
                   
                   
                 ESP: 469. 
               
               
                 184 
                 1 
                 NMR1: 1.37(3H, t), 1.60-1.83(8H, m), 2.30(3H, s), 
               
               
                   
                   
                 3.36-3.40(4H, m), 4.18(2H, q), 4.54-4.60(1H, m), 
               
               
                   
                   
                 6.75-6.81(2H, m), 7.21(1H, d), 7.30(1H, d), 
               
               
                   
                   
                 7.81(1H, d), 7.92(1H, s), 8.16-8.21(1H, m), 
               
               
                   
                   
                 8.49-8.54(1H, m). 
               
               
                   
                   
                 ESP: 503. 
               
               
                 185 
                 1 
                 NMR1: 1.52-1.81(8H, m), 2.10-2.20(1H, m), 2.30(3H, s), 
               
               
                   
                   
                 2.37(3H, s), 3.37-3.43(4H, m), 4.48-4.53(1H, m), 
               
               
                   
                   
                 6.72-6.78(2H, m), 7.31(1H, d), 7.50(1H, d), 7.69(1H, d), 
               
               
                   
                   
                 7.85(1H, s), 8.29-8.36(1H, m), 8.71-8.77(1H, m). 
               
               
                   
                   
                 ESP: 473. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 155 
               
               
                   
               
               
                 Ex 
                 Syn 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 186 
                 3 
                 NMR1: 0.67-0.78(2H, m), 0.95-1.50(2H, m), 
               
               
                   
                   
                 1.57-1.86(8H, m), 1.88-2.02(1H, m), 2.30(3H, s), 
               
               
                   
                   
                 2.31-2.43(1H, m), 3.26-3.50(4H, m), 4.53-4.62(1H, m), 
               
               
                   
                   
                 6.74-6.82(2H, m), 7.15(2H, d), 7.26-7.34(1H, m), 
               
               
                   
                   
                 7.74(2H, d), 8.15-8.23(1H, m), 8.40-8.50(1H, m). 
               
               
                   
                   
                 ESP: 465. 
               
               
                 187 
                 3 
                 NMR1: 1.56-1.86(8H, m), 2.30(3H, s), 2.31-2.41(1H, m), 
               
               
                   
                   
                 3.30-3.52(4H, m), 4.52-4.61(1H, m), 6.74-6.82(2H, m), 
               
               
                   
                   
                 7.28-7.35(1H, m), 7.84(2H, d), 8.03(2H, d), 
               
               
                   
                   
                 8.18-8.26(1H, m), 8.75-8.83(1H, m). 
               
               
                   
                   
                 ESP: 493. 
               
               
                 188 
                 3 
                 NMR1: 1.57-1.86(8H, m), 2.30(3H, s), 2.32-2.43(1H, m), 
               
               
                   
                   
                 3.30-3.50(4H, m), 4.53-4.61(1H, m), 6.74-6.83(2H, m), 
               
               
                   
                   
                 7.27-7.34(1H, m), 7.74-7.86(2H, m), 8.05-8.10(1H, m), 
               
               
                   
                   
                 8.17-8.25(1H, m), 8.70-8.80(1H, m). 
               
               
                   
                   
                 ESP: 493. 
               
               
                 189 
                 3 
                 NMR1: 0.27-0.37(2H, m), 0.51-0.62(2H, m), 
               
               
                   
                   
                 1.14-1.30(1H, m), 1.56-1.87(8H, m), 2.30(3H, s), 
               
               
                   
                   
                 2.32-2.42(1H, m), 3.28-3.48(4H, m), 3.83-3.90(2H, m), 
               
               
                   
                   
                 4.52-4.62(1H, m), 6.74-6.83(2H, m), 6.96(2H, d), 
               
               
                   
                   
                 7.27-7.34(1H, m), 7.78(2H, d), 8.15-8.24(1H, m), 
               
               
                   
                   
                 8.34-8.43(1H, m). 
               
               
                   
                   
                 ESP: 495. 
               
               
                 190 
                 4 
                 NMR1: 1.57-1.85(8H, m), 2.30(3H, s), 2.31-2.41(1H, m), 
               
               
                   
                   
                 3.25-3.48(4H, m), 4.53-4.61(1H, m), 6.74-6.82(2H, m), 
               
               
                   
                   
                 7.27-7.34(1H, m), 7.46(2H, d), 7.95(2H, d), 
               
               
                   
                   
                 8.16-8.24(1H, m), 8.63-8.71(1H, m). 
               
               
                   
                   
                 ESP: 509. 
               
               
                 191 
                 3 
                 NMR1: 1.20-1.42(2H, m), 1.58-1.90(10H, m), 
               
               
                   
                   
                 1.90-2.11(1H, m), 2.31(3H, s), 2.32-2.44(1H, m), 
               
               
                   
                   
                 3.26-3.46(6H, m), 3.84-3.93(4H, m), 4.54-4.62(1H, m), 
               
               
                   
                   
                 6.74-6.82(2H, m), 6.98(2H, d), 7.28-7.34(1H, m), 
               
               
                   
                   
                 7.80(2H, d), 8.14-8.23(1H, m), 8.36-8.44(1H, m). 
               
               
                   
                   
                 ESP: 539. 
               
               
                 192 
                 2 
                 NMR1: 1.57-1.86(8H, m), 2.24-2.42(4H, m), 
               
               
                   
                   
                 3.20-3.46(4H, m), 4.53-4.62(1H, m), 6.72-6.82(2H, m), 
               
               
                   
                   
                 6.90-6.98(1H, m), 7.08-7.16(1H, m), 7.18-7.42(3H, m), 
               
               
                   
                   
                 8.04-8.20(3H, m). 
               
               
                   
                   
                 ESP: 474. 
               
               
                 193 
                 3 
                 ESP: 527. 
               
               
                 194 
                 3 
                 ESP: 499. 
               
               
                 195 
                 3 
                 ESP: 509. 
               
               
                 196 
                 3 
                 ESP: 497. 
               
               
                 197 
                 3 
                 ESP: 497. 
               
               
                 198 
                 3 
                 ESP: 527. 
               
               
                 199 
                 3 
                 ESP: 527. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 156 
               
               
                   
                   
               
               
                   
                 Ex 
                 Syn 
                 Data 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 200 
                 200 
                 ESP: 475. 
               
               
                   
                 201 
                 201 
                 ESP: 475. 
               
               
                   
                 202 
                 202 
                 ESP: 447. 
               
               
                   
                 203 
                 203 
                 ESP: 474. 
               
               
                   
                 204 
                 204 
                 ESP: 503. 
               
               
                   
                 205 
                 205 
                 ESP: 518. 
               
               
                   
                 206 
                 206 
                 ESP: 512. 
               
               
                   
                 207 
                 207 
                 ESP: 433. 
               
               
                   
                 208 
                 208 
                 ESP: 447. 
               
               
                   
                 209 
                 209 
                 ESN: 430. 
               
               
                   
                 210 
                 210 
                 ESP: 474. 
               
               
                   
                 211 
                 3 
                 ESP: 464. 
               
               
                   
                 212 
                 3 
                 ESP: 517. 
               
               
                   
                 213 
                 3 
                 ESP: 480. 
               
               
                   
                 214 
                 3 
                 ESP: 521. 
               
               
                   
                 215 
                 3 
                 ESP: 513, 515. 
               
               
                   
                 216 
                 3 
                 ESP: 491. 
               
               
                   
                 217 
                 3 
                 ESP: 461. 
               
               
                   
                 218 
                 3 
                 ESP: 463, 465. 
               
               
                   
                 219 
                 3 
                 ESP: 513, 515. 
               
               
                   
                 220 
                 3 
                 ESP: 529, 531. 
               
               
                   
                 221 
                 3 
                 ESP: 477. 
               
               
                   
                 222 
                 3 
                 ESP: 477. 
               
               
                   
                 223 
                 3 
                 ESP: 491. 
               
               
                   
                 224 
                 3 
                 ESP: 527. 
               
               
                   
                 225 
                 3 
                 ESP: 543. 
               
               
                   
                 226 
                 4 
                 ESP: 511. 
               
               
                   
                 227 
                 3 
                 ESP: 527. 
               
               
                   
                 228 
                 3 
                 ESP: 527. 
               
               
                   
                 229 
                 3 
                 ESP: 477. 
               
               
                   
                 230 
                 3 
                 ESP: 489, 491. 
               
               
                   
                 231 
                 3 
                 ESP: 493, 495. 
               
               
                   
                 232 
                 3 
                 ESP: 499. 
               
               
                   
                 233 
                 3 
                 ESP: 465. 
               
               
                   
                 234 
                 3 
                 ESP: 475. 
               
               
                   
                 235 
                 3 
                 ESP: 465. 
               
               
                   
                 236 
                 3 
                 ESP: 469. 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 157 
               
               
                   
                   
               
               
                   
                 Ex 
                 Syn 
                 Data 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 237 
                 3 
                 ESP: 443. 
               
               
                   
                 238 
                 3 
                 ESP: 463. 
               
               
                   
                 239 
                 3 
                 ESP: 497. 
               
               
                   
                 240 
                 3 
                 ESP: 439 
               
               
                   
                 241 
                 3 
                 ESP: 479, 481. 
               
               
                   
                 242 
                 3 
                 ESP: 509. 
               
               
                   
                 243 
                 3 
                 ESP: 487. 
               
               
                   
                 244 
                 1 
                 ESN: 478. 
               
               
                   
                 245 
                 1 
                 ESN: 488. 
               
               
                   
                 246 
                 1 
                 ESN: 450. 
               
               
                   
                 247 
                 1 
                 ESN: 471. 
               
               
                   
                 248 
                 1 
                 ESP: 513. 
               
               
                   
                 249 
                 1 
                 ESP: 477. 
               
               
                   
                 250 
                 1 
                 ESN: 471. 
               
               
                   
                 251 
                 3 
                 ESP: 485. 
               
               
                   
                 252 
                 3 
                 ESP: 499. 
               
               
                   
                 253 
                 3 
                 ESP: 503. 
               
               
                   
                 254 
                 3 
                 ESP: 478. 
               
               
                   
                 255 
                 3 
                 ESP: 548. 
               
               
                   
                 256 
                 3 
                 ESP: 532. 
               
               
                   
                 257 
                 3 
                 ESP: 498. 
               
               
                   
                 258 
                 3 
                 ESP: 483. 
               
               
                   
                 259 
                 3 
                 ESP: 495. 
               
               
                   
                 260 
                 2 
                 ESP: 528. 
               
               
                   
                 261 
                 2 
                 ESP: 474. 
               
               
                   
                 262 
                 200 
                 ESP: 485. 
               
               
                   
                 263 
                 1 
                 ESN: 457. 
               
               
                   
                 264 
                 1 
                 ESN: 457. 
               
               
                   
                 265 
                 1 
                 ESP: 513. 
               
               
                   
                 266 
                 3 
                 ESP: 459. 
               
               
                   
                 267 
                 3 
                 ESP: 483. 
               
               
                   
                 268 
                 3 
                 ESP: 465. 
               
               
                   
                 269 
                 4 
                 ESP: 475. 
               
               
                   
                 270 
                 4 
                 ESP: 495. 
               
               
                   
                 271 
                 3 
                 ESP: 511. 
               
               
                   
                 272 
                 3 
                 ESP: 495. 
               
               
                   
                 273 
                 3 
                 ESP: 503. 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 158 
               
               
                   
               
               
                 Ex 
                 Syn 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 274 
                 3 
                 ESP: 503. 
               
               
                 275 
                 3 
                 ESP: 519, 521. 
               
               
                 276 
                 3 
                 ESP: 499. 
               
               
                 277 
                 3 
                 ESP: 469. 
               
               
                 278 
                 200 
                 ESP: 461. 
               
               
                 279 
                 3 
                 ESP: 439. 
               
               
                 280 
                 3 
                 ESP: 453. 
               
               
                 281 
                 3 
                 ESP: 473. 
               
               
                 282 
                 1 
                 ESP: 495. 
               
               
                 283 
                 1 
                 ESP: 489. 
               
               
                 284 
                 1 
                 ESP: 529. 
               
               
                 285 
                 1 
                 ESN: 511. 
               
               
                 286 
                 1 
                 ESP: 523. 
               
               
                 287 
                 1 
                 ESP: 513. 
               
               
                 288 
                 1 
                 ESP: 493. 
               
               
                 289 
                 1 
                 ESP: 485. 
               
               
                 290 
                 3 
                 ESP: 465. 
               
               
                 291 
                 3 
                 ESP: 479. 
               
               
                 292 
                 3 
                 ESP: 483. 
               
               
                 293 
                 3 
                 ESP: 489. 
               
               
                 294 
                 3 
                 ESN: 491. 
               
               
                 295 
                 1 
                 ESN: 460. 
               
               
                 296 
                 1 
                 ESP: 460. 
               
               
                 297 
                 1 
                 ESP: 486. 
               
               
                 298 
                 1 
                 ESP: 457. 
               
               
                 299 
                 4 
                 NMR1: 1.6-1.84(8H, m), 2.32-2.44(1H, m), 
               
               
                   
                   
                 3.40-3.52(4H, m), 4.58-4.66(1H, m), 6.77-6.85(2H, m), 
               
               
                   
                   
                 7.56-7.66(2H, m), 7.91-8.05(4H, m), 8.45(1H, s), 
               
               
                   
                   
                 8.66-8.72(2H, m), 12-12.3(1H, br). 
               
               
                   
                   
                 ESP: 497. 
               
               
                 300 
                 4 
                 NMR1: 1.6-1.94(8H, m), 2.32-2.45(1H, m), 
               
               
                   
                   
                 3.42-3.6(4H, m), 4.67-4.76(1H, m), 7.10-7.20(1H, m), 
               
               
                   
                   
                 7.39-7.50(1H, m), 7.55-7.67(2H, m), 7.90-8.10(4H, m), 
               
               
                   
                   
                 8.36-8.43(1H, m), 8.45(1H, s), 8.70-8.83(1H, m), 
               
               
                   
                   
                 12.00-12.30(1H, br). 
               
               
                   
                   
                 ESP: 497. 
               
               
                 301 
                 4 
                 ESN: 479. 
               
               
                 302 
                 4 
                 ESN: 479. 
               
               
                 303 
                 3 
                 ESN: 485. 
               
               
                 304 
                 3 
                 ESN: 513. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 159 
               
               
                   
               
               
                 Ex 
                 Syn 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 305 
                 3 
                 ESN: 529. 
               
               
                 306 
                 3 
                 ESN: 493. 
               
               
                 307 
                 3 
                 ESN: 485. 
               
               
                 308 
                 3 
                 ESN: 480. 
               
               
                 309 
                 3 
                 ESP: 467. 
               
               
                 310 
                 3 
                 ESP: 495. 
               
               
                 311 
                 3 
                 ESP: 509. 
               
               
                 312 
                 3 
                 ESP: 529, 531. 
               
               
                 313 
                 3 
                 ESP: 546. 
               
               
                 314 
                 200 
                 ESP: 546. 
               
               
                 315 
                 3 
                 ESP: 491. 
               
               
                 316 
                 4 
                 ESP: 501. 
               
               
                 317 
                 3 
                 ESP: 485. 
               
               
                 318 
                 3 
                 ESP: 485. 
               
               
                 319 
                 3 
                 ESP: 485. 
               
               
                 320 
                 3 
                 ESP: 485. 
               
               
                 321 
                 3 
                 ESN: 525. 
               
               
                 322 
                 3 
                 ESN: 492. 
               
               
                 323 
                 2 
                 ESN: 476. 
               
               
                 324 
                 5 
                 ESN: 508. 
               
               
                 325 
                 5 
                 ESP: 508. 
               
               
                 326 
                 3 
                 NMR1: 1.55-1.89(8H, m), 2.29-2.46(1H, m), 
               
               
                   
                   
                 3.37-3.48(4H, m), 4.57-4.69(1H, m), 6.99(2H, d), 
               
               
                   
                   
                 7.38-7.52(2H, d), 7.81(2H, d), 7.90-8.12 (3H, m), 
               
               
                   
                   
                 8.43-8.56(1H, m), 8.83-8.99(1H, m), 
               
               
                   
                   
                 12.06-12.26(1H, m). 
               
               
                   
                   
                 ESP: 467. 
               
               
                 327 
                 3 
                 ESP: 467. 
               
               
                 328 
                 3 
                 ESP: 481. 
               
               
                 329 
                 3 
                 ESP: 495. 
               
               
                 330 
                 3 
                 ESP: 535. 
               
               
                 331 
                 3 
                 ESP: 519. 
               
               
                 332 
                 3 
                 ESP: 491. 
               
               
                 333 
                 3 
                 ESP: 487. 
               
               
                 334 
                 3 
                 ESP: 457. 
               
               
                 335 
                 3 
                 ESP: 501. 
               
               
                 336 
                 3 
                 ESP: 501. 
               
               
                 337 
                 3 
                 ESP: 501. 
               
               
                 338 
                 3 
                 ESP: 489, 491. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 160 
               
               
                   
                   
               
               
                   
                 Ex 
                 Syn 
                 Data 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 339 
                 3 
                 ESP: 515, 517. 
               
               
                   
                 340 
                 3 
                 ESP: 537, 539. 
               
               
                   
                 341 
                 3 
                 ESP: 569. 
               
               
                   
                 342 
                 3 
                 ESP: 441. 
               
               
                   
                 343 
                 3 
                 ESP: 590, 592. 
               
               
                   
                 344 
                 3 
                 ESP: 530. 
               
               
                   
                 345 
                 3 
                 ESP: 443. 
               
               
                   
                 346 
                 3 
                 ESP: 491. 
               
               
                   
                 347 
                 4 
                 ESP: 475. 
               
               
                   
                 348 
                 3 
                 ESP: 485. 
               
               
                   
                 349 
                 3 
                 ESP: 537. 
               
               
                   
                 350 
                 3 
                 ESP: 475. 
               
               
                   
                 351 
                 3 
                 ESP: 509. 
               
               
                   
                 352 
                 3 
                 ESP: 485. 
               
               
                   
                 353 
                 3 
                 ESP: 547. 
               
               
                   
                 354 
                 1 
                 ESP: 439. 
               
               
                   
                 355 
                 1 
                 ESP: 465. 
               
               
                   
                 356 
                 1 
                 ESP: 453. 
               
               
                   
                 357 
                 1 
                 ESP: 467. 
               
               
                   
                 358 
                 1 
                 ESP: 469. 
               
               
                   
                 359 
                 200 
                 ESP: 545. 
               
               
                   
                 360 
                 2 
                 ESN: 488. 
               
               
                   
                 361 
                 3 
                 ESP: 507. 
               
               
                   
                 362 
                 3 
                 ESP: 491. 
               
               
                   
                 363 
                 3 
                 ESP: 485. 
               
               
                   
                 364 
                 3 
                 ESP: 457. 
               
               
                   
                 365 
                 3 
                 ESP: 475. 
               
               
                   
                 366 
                 3 
                 ESP: 481. 
               
               
                   
                 367 
                 3 
                 ESP: 495. 
               
               
                   
                 368 
                 3 
                 ESP: 479. 
               
               
                   
                 369 
                 3 
                 ESP: 521. 
               
               
                   
                 370 
                 3 
                 ESP: 605. 
               
               
                   
                 371 
                 3 
                 ESP: 464. 
               
               
                   
                 372 
                 3 
                 ESN: 480, 482. 
               
               
                   
                 373 
                 3 
                 ESP: 505. 
               
               
                   
                 374 
                 3 
                 ESP: 519. 
               
               
                   
                 375 
                 3 
                 ESP: 535. 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 161 
               
               
                   
                   
               
               
                   
                 Ex 
                 Syn 
                 Data 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 376 
                 3 
                 ESP: 501. 
               
               
                   
                 377 
                 3 
                 ESP: 479. 
               
               
                   
                 378 
                 3 
                 ESP: 519, 521. 
               
               
                   
                 379 
                 3 
                 ESN: 455. 
               
               
                   
                 380 
                 3 
                 ESN: 473. 
               
               
                   
                 381 
                 3 
                 ESN: 473. 
               
               
                   
                 382 
                 1 
                 ESN: 451. 
               
               
                   
                 383 
                 1 
                 ESN: 475. 
               
               
                   
                 384 
                 1 
                 ESN: 475. 
               
               
                   
                 385 
                 1 
                 ESN: 457. 
               
               
                   
                 386 
                 1 
                 ESP: 517. 
               
               
                   
                 387 
                 1 
                 ESP: 535. 
               
               
                   
                 388 
                 4 
                 ESP: 479. 
               
               
                   
                 389 
                 3 
                 ESP: 495. 
               
               
                   
                 390 
                 3 
                 ESP: 507. 
               
               
                   
                 391 
                 3 
                 ESP: 481. 
               
               
                   
                 392 
                 4 
                 ESP: 461. 
               
               
                   
                 393 
                 3 
                 ESP: 501. 
               
               
                   
                 394 
                 3 
                 ESP: 485. 
               
               
                   
                 395 
                 3 
                 ESP: 485. 
               
               
                   
                 396 
                 3 
                 ESP: 535. 
               
               
                   
                 397 
                 3 
                 ESP: 521. 
               
               
                   
                 398 
                 3 
                 ESP: 535. 
               
               
                   
                 399 
                 3 
                 ESP: 539. 
               
               
                   
                 400 
                 3 
                 ESP: 513. 
               
               
                   
                 401 
                 3 
                 ESP: 513. 
               
               
                   
                 402 
                 3 
                 ESP: 509. 
               
               
                   
                 403 
                 3 
                 ESP: 482. 
               
               
                   
                 404 
                 1 
                 ESP: 469. 
               
               
                   
                 405 
                 1 
                 ESP: 551. 
               
               
                   
                 406 
                 1 
                 ESP: 551. 
               
               
                   
                 407 
                 1 
                 ESP: 551. 
               
               
                   
                 408 
                 1 
                 ESP: 531. 
               
               
                   
                 409 
                 1 
                 ESP: 531. 
               
               
                   
                 410 
                 3 
                 ESP: 491. 
               
               
                   
                 411 
                 3 
                 ESP: 509. 
               
               
                   
                 412 
                 3 
                 ESP: 527. 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 162 
               
               
                   
               
               
                 Ex 
                 Syn 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 413 
                 5 
                 ESP: 522. 
               
               
                 414 
                 5 
                 ESP: 452. 
               
               
                 415 
                 5 
                 ESP: 480. 
               
               
                 416 
                 5 
                 ESP: 432. 
               
               
                 417 
                 5 
                 ESP: 466. 
               
               
                 418 
                 2 
                 ESP: 444. 
               
               
                 419 
                 2 
                 ESP: 440. 
               
               
                 420 
                 2 
                 ESP: 494. 
               
               
                 421 
                 5 
                 ESP: 466. 
               
               
                 422 
                 5 
                 ESP: 528. 
               
               
                 423 
                 5 
                 ESP: 529. 
               
               
                 424 
                 5 
                 ESP: 529. 
               
               
                 425 
                 5 
                 ESP: 544. 
               
               
                 426 
                 5 
                 ESP: 544. 
               
               
                 427 
                 5 
                 ESP: 544. 
               
               
                 428 
                 3 
                 ESP: 497. 
               
               
                 429 
                 3 
                 ESP: 523. 
               
               
                 430 
                 3 
                 ESP: 493. 
               
               
                 431 
                 3 
                 ESP: 505. 
               
               
                 432 
                 3 
                 ESP: 505. 
               
               
                 433 
                 3 
                 ESP: 531. 
               
               
                 434 
                 3 
                 ESP: 547. 
               
               
                 435 
                 3 
                 ESP: 537. 
               
               
                 436 
                 3 
                 ESP: 537. 
               
               
                 437 
                 4 
                 ESP: 515. 
               
               
                 438 
                 4 
                 ESP: 515, 517. 
               
               
                 439 
                 3 
                 NMR1: 0.91(3H, d), 1.10-1.22(2H, m), 1.48-1.71(7H, m), 
               
               
                   
                   
                 1.74-1.88(4H, m), 2.11-2.19(1H, m), 2.66-2.77(2H, m), 
               
               
                   
                   
                 3.36-3.44(4H, m), 3.77-3.84(2H, m), 4.51-4.59(1H, m), 
               
               
                   
                   
                 6.90(2H, d), 6.99(2H, d), 7.75(2H, d), 7.85(2H, d), 
               
               
                   
                   
                 8.71-8.80(1H, m), 8.82-8.91(1H, m). 
               
               
                   
                   
                 ESP: 508. 
               
               
                 440 
                 200 
                 ESN: 458. 
               
               
                 441 
                 3 
                 ESP: 517. 
               
               
                 442 
                 3 
                 ESP: 528. 
               
               
                 443 
                 3 
                 ESP: 571. 
               
               
                 444 
                 3 
                 ESP: 501. 
               
               
                 445 
                 3 
                 ESP: 505. 
               
               
                 446 
                 3 
                 ESP: 517. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 163 
               
               
                   
               
               
                 Ex 
                 Syn 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 447 
                 3 
                 ESP: 523. 
               
               
                 448 
                 3 
                 ESP: 501. 
               
               
                 449 
                 3 
                 ESP: 501. 
               
               
                 450 
                 3 
                 ESP: 501. 
               
               
                 451 
                 3 
                 ESP: 485. 
               
               
                 452 
                 3 
                 ESP: 535. 
               
               
                 453 
                 3 
                 ESP: 481. 
               
               
                 454 
                 4 
                 NMR1: 1.62-1.88(8H, m), 2.34-2.44(1H, m), 
               
               
                   
                   
                 3.43-3.52(4H, m), 4.66-4.73(1H. m), 7.27(1H, q), 
               
               
                   
                   
                 7.51(1H, q), 7.56-7.64(2H,m), 7.90-8.03(4H, m), 
               
               
                   
                   
                 8.28-8.34(1H, m), 8.44(1H, s), 8.71-8.77(1H, m), 
               
               
                   
                   
                 11.99-12.33(1H, m). 
               
               
                   
                   
                 ESP: 497. 
               
               
                 455 
                 4 
                 ESP: 515. 
               
               
                 456 
                 4 
                 ESP: 515, 517. 
               
               
                 457 
                 3 
                 ESP: 497. 
               
               
                 458 
                 3 
                 ESP: 497. 
               
               
                 459 
                 3 
                 ESP: 497. 
               
               
                 460 
                 3 
                 ESP: 493. 
               
               
                 461 
                 3 
                 ESP: 487. 
               
               
                 462 
                 3 
                 ESP: 531. 
               
               
                 463 
                 3 
                 ESP: 503. 
               
               
                 464 
                 3 
                 NMR1: 1.59-1.87(8H, m), 2.34-2.44(1H, m), 
               
               
                   
                   
                 3.38-3.50(4H, m), 4.67-4.73(1H, m), 7.14(1H, t), 
               
               
                   
                   
                 7.39-7.49(3H, m), 7.91-7.96(1H, m), 7.99-8.07(2H, m), 
               
               
                   
                   
                 8.36-8.43(1H, m), 8.84-8.90(1H, m), 2.06-12.26(1H, m). 
               
               
                   
                   
                 ESP: 503. 
               
               
                 465 
                 3 
                 NMR1: 1.61-1.87(8H, m), 2.33-2.44(1H, m), 
               
               
                   
                   
                 3.37-3.50(4H, m), 4.65-4.73(1H, m), 7.27(1H, q), 
               
               
                   
                   
                 7.40-7.54(3H, m), 7.92-7.96(1H, m), 8.00-8.06(2H, m), 
               
               
                   
                   
                 8.28-8.34(1H, m), 8.84-8.90(1H, m), 
               
               
                   
                   
                 12.06-12.28(1H, m). 
               
               
                   
                   
                 ESP: 503. 
               
               
                 466 
                 3 
                 ESP: 485. 
               
               
                 467 
                 3 
                 ESP: 431. 
               
               
                 468 
                 3 
                 ESP: 493. 
               
               
                 469 
                 3 
                 NMR1: 1.60-1.86(8H, m), 2.32-2.44(1H, m), 
               
               
                   
                   
                 3.44-3.54(4H, m), 4.58-4.66(1H, m), 7.00(2H, d), 
               
               
                   
                   
                 7.55-7.65(2H, m), 7.81(2H, d), 7.86-7.93(1H, m), 
               
               
                   
                   
                 8.07-8.15(1H, m), 8.42-8.56(2H, m), 
               
               
                   
                   
                 11.8-12.6(1H, br). 
               
               
                   
                   
                 ESP: 501. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 164 
               
               
                   
               
               
                 Ex 
                 Syn 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 470 
                 3 
                 NMR1: 1.60-1.86(8H, m), 2.30-2.44(1H, m), 
               
               
                   
                   
                 3.38-3.48(4H, m), 4.56-4.66(1H, m), 7.00(2H, d), 
               
               
                   
                   
                 7.28-7.36(1H, m), 7.81(2H, d), 7.91-8.01(2H, m), 
               
               
                   
                   
                 8.05(1H, s), 8.44-8.51(1H, m), 8.87-8.94(1H, m), 
               
               
                   
                   
                 11.9-12.3(1H, br). 
               
               
                   
                   
                 ESP: 485. 
               
               
                 471 
                 3 
                 ESP: 551. 
               
               
                 472 
                 3 
                 ESP: 498. 
               
               
                 473 
                 3 
                 ESP: 451. 
               
               
                 474 
                 3 
                 ESP: 493. 
               
               
                 475 
                 5 
                 ESN: 484. 
               
               
                 476 
                 5 
                 ESN: 484. 
               
               
                 477 
                 5 
                 ESN: 484. 
               
               
                 478 
                 5 
                 ESP: 542, 544. 
               
               
                 479 
                 5 
                 ESP: 564, 566. 
               
               
                 480 
                 5 
                 ESP: 564, 566. 
               
               
                 481 
                 5 
                 ESP: 564, 566. 
               
               
                 482 
                 5 
                 ESP: 546, 548. 
               
               
                 483 
                 5 
                 ESP: 546, 548. 
               
               
                 484 
                 3 
                 ESP: 503. 
               
               
                 485 
                 3 
                 ESP: 503. 
               
               
                 486 
                 3 
                 NMR1: 1.64-1.88(8H, m), 2.33-2.43(1H, m), 
               
               
                   
                   
                 3.40-3.52(4H, m), 4.65-4.73(1H, m), 7.27(1H, q), 
               
               
                   
                   
                 7.48-7.58(2H, m), 7.80-7.88(2H, m), 8.09(1H, d), 
               
               
                   
                   
                 8.27-8.33(1H, m), 8.38(1H, d), 8.63-8.69(1H, m), 
               
               
                   
                   
                 12.08-12.27(1 H, m). 
               
               
                   
                   
                 ESP: 503. 
               
               
                 487 
                 3 
                 ESP: 485. 
               
               
                 488 
                 3 
                 ESP: 485. 
               
               
                 489 
                 3 
                 ESP: 487, 489. 
               
               
                 490 
                 3 
                 NMR1: 1.64-1.87(8H, m), 2.35-2.44(1H, m), 
               
               
                   
                   
                 3.35-3.50(4H, m), 4.67-4.75(1H, m), 7.14(1H, t), 
               
               
                   
                   
                 7.18(1H, d), 7.40(1H, t), 7.60(1H, d), 
               
               
                   
                   
                 8.34-8.43(1H, m), 8.67-8.80(1H, m), 
               
               
                   
                   
                 12.06-12.26(1H, m). 
               
               
                   
                   
                 ESP: 487, 489. 
               
               
                 491 
                 3 
                 ESP: 487. 
               
               
                 492 
                 3 
                 ESP: 469, 471. 
               
               
                 493 
                 3 
                 ESP: 469, 471. 
               
               
                 494 
                 1 
                 ESP: 453. 
               
               
                 495 
                 1 
                 ESP: 521. 
               
               
                 496 
                 5 
                 ESN: 434. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 165 
               
               
                   
                   
               
               
                   
                 Ex 
                 Syn 
                 Data 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 497 
                 5 
                 ESP: 460. 
               
               
                   
                 498 
                 5 
                 ESP: 480. 
               
               
                   
                 499 
                 3 
                 ESN: 478. 
               
               
                   
                 500 
                 3 
                 ESN: 492. 
               
               
                   
                 501 
                 5 
                 ESP: 462. 
               
               
                   
                 502 
                 5 
                 ESP: 488. 
               
               
                   
                 503 
                 5 
                 ESN: 526. 
               
               
                   
                 504 
                 5 
                 ESN: 544. 
               
               
                   
                 505 
                 5 
                 ESN: 452. 
               
               
                   
                 506 
                 5 
                 ESN: 470. 
               
               
                   
                 507 
                 5 
                 ESN: 484. 
               
               
                   
                 508 
                 3 
                 ESP: 483. 
               
               
                   
                 509 
                 3 
                 ESP: 483. 
               
               
                   
                 510 
                 3 
                 ESP: 483. 
               
               
                   
                 511 
                 3 
                 ESP: 483. 
               
               
                   
                 512 
                 3 
                 ESP: 499, 501. 
               
               
                   
                 513 
                 3 
                 ESP: 499, 501. 
               
               
                   
                 514 
                 3 
                 ESP: 499, 501. 
               
               
                   
                 515 
                 3 
                 ESP: 465. 
               
               
                   
                 516 
                 3 
                 ESP: 537, 539. 
               
               
                   
                 517 
                 3 
                 ESP: 537, 539. 
               
               
                   
                 518 
                 3 
                 ESP: 537, 539. 
               
               
                   
                 519 
                 3 
                 ESP: 521. 
               
               
                   
                 520 
                 3 
                 ESP: 521. 
               
               
                   
                 521 
                 3 
                 ESP: 537, 539. 
               
               
                   
                 522 
                 3 
                 ESP: 537, 539. 
               
               
                   
                 523 
                 3 
                 ESP: 537, 539. 
               
               
                   
                 524 
                 3 
                 ESP: 521. 
               
               
                   
                 525 
                 3 
                 ESP: 521. 
               
               
                   
                 526 
                 3 
                 ESP: 521. 
               
               
                   
                 527 
                 3 
                 ESP: 521. 
               
               
                   
                 528 
                 3 
                 ESP: 519. 
               
               
                   
                 529 
                 3 
                 ESP: 519. 
               
               
                   
                 530 
                 3 
                 ESP: 519. 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 166 
               
               
                   
               
               
                 Ex 
                 Syn 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 531 
                 200 
                 NMR1: 1.60-1.86(8H, m), 2.30-2.44(1H, m), 
               
               
                   
                   
                 3.38-3.50(4H, m), 4.58-4.68(1H, m), 6.82-6.94(2H, m), 
               
               
                   
                   
                 7.31-7.39(1H, m), 7.63(1H, t), 7.77-7.83(1H, m), 
               
               
                   
                   
                 8.03(1H, s), 8.04-8.10(1H, m), 8.14-8.22(1H, m), 
               
               
                   
                   
                 8.88-8.96(1H, m), 11.9-12.4(1H, br). 
               
               
                   
                   
                 ESP: 503. 
               
               
                 532 
                 3 
                 ESP: 503. 
               
               
                 533 
                 3 
                 ESP: 519. 
               
               
                 534 
                 3 
                 ESP: 519. 
               
               
                 535 
                 3 
                 ESP: 519. 
               
               
                 536 
                 3 
                 ESP: 503. 
               
               
                 537 
                 3 
                 ESP: 503. 
               
               
                 538 
                 3 
                 ESP: 537. 
               
               
                 539 
                 3 
                 ESP: 537. 
               
               
                 540 
                 3 
                 ESP: 537. 
               
               
                 541 
                 3 
                 ESP: 491. 
               
               
                 542 
                 3 
                 ESP: 526. 
               
               
                 543 
                 3 
                 ESP: 512. 
               
               
                 544 
                 3 
                 ESP: 498. 
               
               
                 545 
                 3 
                 ESN: 542. 
               
               
                 546 
                 3 
                 ESN: 528. 
               
               
                 547 
                 3 
                 ESN: 514. 
               
               
                 548 
                 3 
                 ESN: 482. 
               
               
                 549 
                 3 
                 ESP: 503. 
               
               
                 550 
                 3 
                 NMR1: 1.60-1.88(8H, m), 2.30-2.44(1H, m), 
               
               
                   
                   
                 3.39-3.53(4H, m), 4.66-4.77(1H, m), 7.14(1H, t), 
               
               
                   
                   
                 7.31-7.53(3H, m), 7.83(1H, d), 8.15(1H, d), 
               
               
                   
                   
                 8.37-8.44(1H, m), 8.96-9.04(1H, m), 
               
               
                   
                   
                 11.9-12.3(1H, br). 
               
               
                   
                   
                 ESP: 521. 
               
               
                 551 
                 3 
                 ESP: 521. 
               
               
                 552 
                 3 
                 ESP: 521. 
               
               
                 553 
                 3 
                 ESP: 530. 
               
               
                 554 
                 3 
                 NMR1: 0.91(3H, d), 1.08-1.22(2H, m), 
               
               
                   
                   
                 1.48-1.87(11H, m), 2.34-2.43(1H, m), 
               
               
                   
                   
                 2.66-2.79(2H, m), 3.36-3.44(4H, m), 
               
               
                   
                   
                 3.76-3.86(2H, m), 4.65-4.72(1H, m), 6.92(2H, d), 
               
               
                   
                   
                 7.27(1H, q), 7.50(1H, q), 7.69(2H, d), 
               
               
                   
                   
                 8.22-8.29(2H, m), 12.08-12.28(1H, m). 
               
               
                   
                   
                 ESP: 544. 
               
               
                 555 
                 3 
                 ESP: 516. 
               
               
                 556 
                 3 
                 ESP: 503. 
               
               
                 557 
                 3 
                 ESP: 503. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 167 
               
               
                   
               
               
                 Ex 
                 Syn 
                 Data 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                 558 
                 3 
                 ESP: 521. 
               
               
                 559 
                 3 
                 ESP: 521. 
               
               
                 560 
                 3 
                 ESP: 521. 
               
               
                 561 
                 3 
                 ESN: 514. 
               
               
                 562 
                 3 
                 ESN: 528. 
               
               
                 563 
                 3 
                 ESN: 542. 
               
               
                 564 
                 3 
                 ESP: 503. 
               
               
                 565 
                 5 
                 ESP: 454. 
               
               
                 566 
                 1 
                 ESP: 526. 
               
               
                 56 
                 1 
                 ESP: 512. 
               
               
                 568 
                 1 
                 ESP: 498. 
               
               
                 569 
                 1 
                 ESP: 493. 
               
               
                 570 
                 4 
                 ESP: 493. 
               
               
                 571 
                 4 
                 NMR1: 1.22-1.37(2H, m), 1.49-1.67(4H, m), 
               
               
                   
                   
                 1.71-1.91(3H, m), 2.14(2H, d), 3.40-3.52(4H, m), 
               
               
                   
                   
                 4.69-4.78(1H. m), 7.25(1H, q), 7.51(1H, q), 
               
               
                   
                   
                 7.56-7.64(2H, m), 7.90-8.00(4H, m), 
               
               
                   
                   
                 8.28-8.33(1H, m), 8.44(1H, s), 8.72-8.77(1H, m), 
               
               
                   
                   
                 11.90-12.08(1H, m). 
               
               
                   
                   
                 ESP: 511. 
               
               
                 572 
                 3 
                 ESP: 483. 
               
               
                 573 
                 3 
                 ESP: 499. 
               
               
                 574 
                 3 
                 ESP: 499. 
               
               
                 575 
                 3 
                 ESP: 561. 
               
               
                 576 
                 3 
                 ESP: 473. 
               
               
                 577 
                 3 
                 ESP: 465. 
               
               
                 578 
                 5 
                 ESN: 470. 
               
               
                 579 
                 5 
                 ESN: 510. 
               
               
                 580 
                 5 
                 ESN: 556. 
               
               
                 581 
                 5 
                 ESN: 522. 
               
               
                 582 
                 3 
                 ESN: 460. 
               
               
                 583 
                 3 
                 ESN: 461. 
               
               
                 584 
                 3 
                 ESN: 460. 
               
               
                 585 
                 3 
                 ESN: 460. 
               
               
                 586 
                 3 
                 ESN: 466. 
               
               
                 587 
                 3 
                 ESN: 467. 
               
               
                 588 
                 3 
                 ESN: 460. 
               
               
                 589 
                 3 
                 ESN: 507. 
               
               
                 590 
                 200 
                 ESP: 479. 
               
               
                 591 
                 200 
                 ESP: 496. 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 168 
               
               
                   
                   
               
               
                   
                 Ex 
                 Syn 
                 Data 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 592 
                 200 
                 ESP: 494. 
               
               
                   
                 593 
                 200 
                 ESP: 496. 
               
               
                   
                 594 
                 200 
                 ESP: 494. 
               
               
                   
                 595 
                 200 
                 ESP: 497. 
               
               
                   
                 596 
                 3 
                 ESP: 496. 
               
               
                   
                 597 
                 200 
                 ESP: 511. 
               
               
                   
                 598 
                 3 
                 ESP: 501. 
               
               
                   
                 599 
                 203 
                 ESP: 488. 
               
               
                   
                 600 
                 203 
                 ESP: 530. 
               
               
                   
                 601 
                 203 
                 ESP: 543. 
               
               
                   
                 602 
                 200 
                 ESP: 536, 538. 
               
               
                   
                 603 
                 200 
                 ESN: 493. 
               
               
                   
                 604 
                 200 
                 ESP: 536, 538. 
               
               
                   
                 605 
                 200 
                 ESN: 493. 
               
               
                   
                 606 
                 200 
                 ESP: 518, 520. 
               
               
                   
                 607 
                 200 
                 ESN: 475. 
               
               
                   
                 608 
                 200 
                 ESP: 478. 
               
               
                   
                 609 
                 200 
                 ESP: 476. 
               
               
                   
                 610 
                 203 
                 ESP: 536. 
               
               
                   
                 611 
                 203 
                 ESP: 550. 
               
               
                   
                 612 
                 3 
                 ESN: 460. 
               
               
                   
                 613 
                 4 
                 ESP: 497. 
               
               
                   
                 614 
                 3 
                 ESP: 495, 497. 
               
               
                   
                 615 
                 3 
                 ESP: 487. 
               
               
                   
                 616 
                 3 
                 ESP: 530. 
               
               
                   
                 617 
                 3 
                 ESN: 496. 
               
               
                   
                 618 
                 200 
                 ESN: 495. 
               
               
                   
                 619 
                 3 
                 ESN: 457. 
               
               
                   
                 620 
                 200 
                 ESP: 486. 
               
               
                   
                 621 
                 3 
                 ESP: 503. 
               
               
                   
                 622 
                 3 
                 ESP: 537, 539. 
               
               
                   
                 623 
                 3 
                 ESP: 521. 
               
               
                   
                 624 
                 3 
                 ESP: 487. 
               
               
                   
                 625 
                 3 
                 ESP: 495, 497. 
               
               
                   
                 626 
                 3 
                 ESP: 487. 
               
               
                   
                 627 
                 3 
                 ESP: 503. 
               
               
                   
                 628 
                 3 
                 ESN: 449. 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 169 
               
               
                   
                   
               
               
                   
                 Ex 
                 Syn 
                 Data 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 629 
                 200 
                 ESP: 497. 
               
               
                   
                 630 
                 200 
                 ESP: 487, 489. 
               
               
                   
                 631 
                 200 
                 ESP: 503. 
               
               
                   
                 632 
                 5 
                 ESN: 478. 
               
               
                   
                 633 
                 200 
                 ESP: 511. 
               
               
                   
                 634 
                 200 
                 ESP: 509. 
               
               
                   
                 635 
                 200 
                 ESP: 501. 
               
               
                   
                 636 
                 200 
                 ESP: 510. 
               
               
                   
                 637 
                 1 
                 ESP: 460. 
               
               
                   
                 638 
                 202 
                 ESP: 477. 
               
               
                   
                 639 
                 200 
                 ESP: 447. 
               
               
                   
                 640 
                 200 
                 ESN: 443. 
               
               
                   
                 641 
                 200 
                 ESP: 487. 
               
               
                   
                 642 
                 200 
                 ESN: 435. 
               
               
                   
                 643 
                 200 
                 ESP: 447. 
               
               
                   
                 644 
                 200 
                 ESP: 445. 
               
               
                   
                 645 
                 200 
                 ESP: 487. 
               
               
                   
                 646 
                 200 
                 ESP: 437. 
               
               
                   
                 647 
                 6 
                 ESP: 491. 
               
               
                   
                 648 
                 201 
                 ESP: 515. 
               
               
                   
                 649 
                 200 
                 ESP: 459. 
               
               
                   
                 650 
                 3 
                 ESN: 466. 
               
               
                   
                 651 
                 1 
                 ESP: 459. 
               
               
                   
                 652 
                 210 
                 ESP: 500. 
               
               
                   
                   
               
            
           
         
       
     
     INDUSTRIAL APPLICABILITY 
     The compound of the formula (I) or a salt thereof has a DGAT1 inhibitory action, and can be therefore used as an agent for preventing and/or treating obesity, type II diabetes mellitus, fatty liver, and diseases associated with these diseases.