Patent Publication Number: US-2021161707-A1

Title: Dispenser for precise extraction of a semi-solid product

Description:
CROSS-REFERENCE 
     This application is a continuation application of PCT/IB2019/000903, filed Aug. 9, 2019, and claims the benefit of U.S. Provisional Application No. 62/717,197, filed Aug. 10, 2018, all of which are incorporated herein by reference in their entirety. 
    
    
     BACKGROUND OF THE INVENTION 
     A great variety of semi-solid drugs or cosmetics are currently being sold and tested for the treatment of a multitude of medical conditions or for cosmetic reasons. Such semi-solid may comprise products, creams, or gels. The use of such semi-solids to treat their respective medical conditions may comprise applying a set amount of the product to a specific portion of the body. 
     SUMMARY OF THE INVENTION 
     One aspect provided herein is a dispenser for precise secretion of a semi-solid product from a product tube having a shoulder and a dispensing tip, the dispenser comprising: a collar comprising: an aperture configured to accept the dispensing tip; and a proximal surface configured to contact the shoulder of the product tube; and a first surface generally perpendicular to the proximal surface, wherein the first surface comprises at least one hyperacuity target extending from the proximal surface by a dispensing offset length; and wherein the at least one hyperacuity target provides a visual indication corresponding to the dispensing measurement distance and a secreted volume of the semi-solid product. 
     In some embodiments, the at least one hyperacuity target comprises a first hyperacuity target and a second hyperacuity target. In some embodiments, the first hyperacuity target and the second hyperacuity target further extend towards each other to form a hyperacuity target separation gap between a first proximal point on the first hyperacuity target and a second proximal point on the second hyperacuity target. 
     In some embodiments, the hyperacuity target separation gap is about 2 mm to about 60 mm. In some embodiments, the hyperacuity target separation gap is at least about 2 mm. In some embodiments, the hyperacuity target separation gap is at most about 60 mm. In some embodiments, the hyperacuity target separation gap is about 2 mm to about 4 mm, about 2 mm to about 8 mm, about 2 mm to about 10 mm, about 2 mm to about 15 mm, about 2 mm to about 20 mm, about 2 mm to about 30 mm, about 2 mm to about 40 mm, about 2 mm to about 50 mm, about 2 mm to about 60 mm, about 4 mm to about 8 mm, about 4 mm to about 10 mm, about 4 mm to about 15 mm, about 4 mm to about 20 mm, about 4 mm to about 30 mm, about 4 mm to about 40 mm, about 4 mm to about 50 mm, about 4 mm to about 60 mm, about 8 mm to about 10 mm, about 8 mm to about 15 mm, about 8 mm to about 20 mm, about 8 mm to about 30 mm, about 8 mm to about 40 mm, about 8 mm to about 50 mm, about 8 mm to about 60 mm, about 10 mm to about 15 mm, about 10 mm to about 20 mm, about 10 mm to about 30 mm, about 10 mm to about 40 mm, about 10 mm to about 50 mm, about 10 mm to about 60 mm, about 15 mm to about 20 mm, about 15 mm to about 30 mm, about 15 mm to about 40 mm, about 15 mm to about 50 mm, about 15 mm to about 60 mm, about 20 mm to about 30 mm, about 20 mm to about 40 mm, about 20 mm to about 50 mm, about 20 mm to about 60 mm, about 30 mm to about 40 mm, about 30 mm to about 50 mm, about 30 mm to about 60 mm, about 40 mm to about 50 mm, about 40 mm to about 60 mm, or about 50 mm to about 60 mm. In some embodiments, the hyperacuity target separation gap is about 2 mm, about 4 mm, about 8 mm, about 10 mm, about 15 mm, about 20 mm, about 30 mm, about 40 mm, about 50 mm, or about 60 mm. 
     In some embodiments, a distal edge of at least one of the first hyperacuity target and the second hyperacuity target are generally perpendicular to the proximal surface. In some embodiments, the distal edge of the first hyperacuity target and the distal edge of the second hyperacuity target are generally parallel or collinear. In some embodiments, the dispensing offset length is greater than a distance from the shoulder of the product tube to a distal point of the dispensing tip. 
     In some embodiments, the dispensing offset length is about 1 mm to about 100 mm. In some embodiments, the dispensing offset length is at least about 1 mm. In some embodiments, the dispensing offset length is at most about 100 mm. In some embodiments, the dispensing offset length is about 1 mm to about 5 mm, about 1 mm to about 10 mm, about 1 mm to about 20 mm, about 1 mm to about 30 mm, about 1 mm to about 40 mm, about 1 mm to about 50 mm, about 1 mm to about 60 mm, about 1 mm to about 70 mm, about 1 mm to about 80 mm, about 1 mm to about 90 mm, about 1 mm to about 100 mm, about 5 mm to about 10 mm, about 5 mm to about 20 mm, about 5 mm to about 30 mm, about 5 mm to about 40 mm, about 5 mm to about 50 mm, about 5 mm to about 60 mm, about 5 mm to about 70 mm, about 5 mm to about 80 mm, about 5 mm to about 90 mm, about 5 mm to about 100 mm, about 10 mm to about 20 mm, about 10 mm to about 30 mm, about 10 mm to about 40 mm, about 10 mm to about 50 mm, about 10 mm to about 60 mm, about 10 mm to about 70 mm, about 10 mm to about 80 mm, about 10 mm to about 90 mm, about 10 mm to about 100 mm, about 20 mm to about 30 mm, about 20 mm to about 40 mm, about 20 mm to about 50 mm, about 20 mm to about 60 mm, about 20 mm to about 70 mm, about 20 mm to about 80 mm, about 20 mm to about 90 mm, about 20 mm to about 100 mm, about 30 mm to about 40 mm, about 30 mm to about 50 mm, about 30 mm to about 60 mm, about 30 mm to about 70 mm, about 30 mm to about 80 mm, about 30 mm to about 90 mm, about 30 mm to about 100 mm, about 40 mm to about 50 mm, about 40 mm to about 60 mm, about 40 mm to about 70 mm, about 40 mm to about 80 mm, about 40 mm to about 90 mm, about 40 mm to about 100 mm, about 50 mm to about 60 mm, about 50 mm to about 70 mm, about 50 mm to about 80 mm, about 50 mm to about 90 mm, about 50 mm to about 100 mm, about 60 mm to about 70 mm, about 60 mm to about 80 mm, about 60 mm to about 90 mm, about 60 mm to about 100 mm, about 70 mm to about 80 mm, about 70 mm to about 90 mm, about 70 mm to about 100 mm, about 80 mm to about 90 mm, about 80 mm to about 100 mm, or about 90 mm to about 100 mm. In some embodiments, the dispensing offset length is about 1 mm, about 5 mm, about 10 mm, about 20 mm, about 30 mm, about 40 mm, about 50 mm, about 60 mm, about 70 mm, about 80 mm, about 90 mm, or about 100 mm. 
     In some embodiments, the product tube further comprises a cap, and wherein the aperture is further configured to accept the cap. 
     In some embodiments, the aperture has a diameter of about 3 mm to about 50 mm. In some embodiments, the aperture has a diameter of at least about 3 mm. In some embodiments, the aperture has a diameter of at most about 50 mm. In some embodiments, the aperture has a diameter of about 3 mm to about 4 mm, about 3 mm to about 5 mm, about 3 mm to about 6 mm, about 3 mm to about 8 mm, about 3 mm to about 10 mm, about 3 mm to about 20 mm, about 3 mm to about 30 mm, about 3 mm to about 40 mm, about 3 mm to about 50 mm, about 4 mm to about 5 mm, about 4 mm to about 6 mm, about 4 mm to about 8 mm, about 4 mm to about 10 mm, about 4 mm to about 20 mm, about 4 mm to about 30 mm, about 4 mm to about 40 mm, about 4 mm to about 50 mm, about 5 mm to about 6 mm, about 5 mm to about 8 mm, about 5 mm to about 10 mm, about 5 mm to about 20 mm, about 5 mm to about 30 mm, about 5 mm to about 40 mm, about 5 mm to about 50 mm, about 6 mm to about 8 mm, about 6 mm to about 10 mm, about 6 mm to about 20 mm, about 6 mm to about 30 mm, about 6 mm to about 40 mm, about 6 mm to about 50 mm, about 8 mm to about 10 mm, about 8 mm to about 20 mm, about 8 mm to about 30 mm, about 8 mm to about 40 mm, about 8 mm to about 50 mm, about 10 mm to about 20 mm, about 10 mm to about 30 mm, about 10 mm to about 40 mm, about 10 mm to about 50 mm, about 20 mm to about 30 mm, about 20 mm to about 40 mm, about 20 mm to about 50 mm, about 30 mm to about 40 mm, about 30 mm to about 50 mm, or about 40 mm to about 50 mm. In some embodiments, the aperture has a diameter of about 3 mm, about 4 mm, about 5 mm, about 6 mm, about 8 mm, about 10 mm, about 20 mm, about 30 mm, about 40 mm, or about 50 mm. 
     In some embodiments, the first surface further comprises a cavity configured surround at least a portion of the product tube. In some embodiments, the aperture of the collar comprises a threaded feature. In some embodiments, the dispenser comprises plastic, wood, metal, fiberglass, carbon fiber, resin, or any combination thereof. 
     Another aspect provided herein is a product tube for precise secretion of a semi-solid product comprising: a product tube body configured to contain the semi-solid product; a nozzle configured to secrete the semi-solid product from the product tube body; and at least one hyperacuity target extending beyond the nozzle by a dispensing measurement distance. In some embodiments, the at least one hyperacuity target provides a visual indication corresponding to the dispensing measurement distance and a secreted volume of the semi-solid product. 
     In some embodiments, the at least one hyperacuity target comprises a first hyperacuity target and a second hyperacuity target. 
     In some embodiments, the secreted volume is about 1 ul (microliter) to about 10 ul. In some embodiments, the secreted volume is at least about 1 ul. In some embodiments, the secreted volume is at most about 10 ul. In some embodiments, the secreted volume is about 1 ul to about 2 ul, about 1 ul to about 3 ul, about 1 ul to about 4 ul, about 1 ul to about 5 ul, about 1 ul to about 6 ul, about 1 ul to about 7 ul, about 1 ul to about 8 ul, about 1 ul to about 9 ul, about 1 ul to about 10 ul, about 2 ul to about 3 ul, about 2 ul to about 4 ul, about 2 ul to about 5 ul, about 2 ul to about 6 ul, about 2 ul to about 7 ul, about 2 ul to about 8 ul, about 2 ul to about 9 ul, about 2 ul to about 10 ul, about 3 ul to about 4 ul, about 3 ul to about 5 ul, about 3 ul to about 6 ul, about 3 ul to about 7 ul, about 3 ul to about 8 ul, about 3 ul to about 9 ul, about 3 ul to about 10 ul, about 4 ul to about 5 ul, about 4 ul to about 6 ul, about 4 ul to about 7 ul, about 4 ul to about 8 ul, about 4 ul to about 9 ul, about 4 ul to about 10 ul, about 5 ul to about 6 ul, about 5 ul to about 7 ul, about 5 ul to about 8 ul, about 5 ul to about 9 ul, about 5 ul to about 10 ul, about 6 ul to about 7 ul, about 6 ul to about 8 ul, about 6 ul to about 9 ul, about 6 ul to about 10 ul, about 7 ul to about 8 ul, about 7 ul to about 9 ul, about 7 ul to about 10 ul, about 8 ul to about 9 ul, about 8 ul to about 10 ul, or about 9 ul to about 10 ul. In some embodiments, the secreted volume is about 1 ul, about 2 ul, about 3 ul, about 4 ul, about 5 ul, about 6 ul, about 7 ul, about 8 ul, about 9 ul, or about 10 ul. 
     In some embodiments, the secreted amount is about 1 mg (milligram) to about 10 mg. In some embodiments, the secreted amount is at least about 1 mg. In some embodiments, the secreted amount is at most about 10 mg. In some embodiments, the secreted amount is about 1 mg to about 2 mg, about 1 mg to about 3 mg, about 1 mg to about 4 mg, about 1 mg to about 5 mg, about 1 mg to about 6 mg, about 1 mg to about 7 mg, about 1 mg to about 8 mg, about 1 mg to about 9 mg, about 1 mg to about 10 mg, about 2 mg to about 3 mg, about 2 mg to about 4 mg, about 2 mg to about 5 mg, about 2 mg to about 6 mg, about 2 mg to about 7 mg, about 2 mg to about 8 mg, about 2 mg to about 9 mg, about 2 mg to about 10 mg, about 3 mg to about 4 mg, about 3 mg to about 5 mg, about 3 mg to about 6 mg, about 3 mg to about 7 mg, about 3 mg to about 8 mg, about 3 mg to about 9 mg, about 3 mg to about 10 mg, about 4 mg to about 5 mg, about 4 mg to about 6 mg, about 4 mg to about 7 mg, about 4 mg to about 8 mg, about 4 mg to about 9 mg, about 4 mg to about 10 mg, about 5 mg to about 6 mg, about 5 mg to about 7 mg, about 5 mg to about 8 mg, about 5 mg to about 9 mg, about 5 mg to about 10 mg, about 6 mg to about 7 mg, about 6 mg to about 8 mg, about 6 mg to about 9 mg, about 6 mg to about 10 mg, about 7 mg to about 8 mg, about 7 mg to about 9 mg, about 7 mg to about 10 mg, about 8 mg to about 9 mg, about 8 mg to about 10 mg, or about 9 mg to about 10 mg. In some embodiments, the secreted amount is about 1 mg, about 2 mg, about 3 mg, about 4 mg, about 5 mg, about 6 mg, about 7 mg, about 8 mg, about 9 mg, or about 10 mg. 
     In some embodiments, an accuracy of the secreted volume is about 0.1 ul to about 10 ul. In some embodiments, the accuracy is at least about 0.1 ul. In some embodiments, the accuracy is at most about 10 ul. In some embodiments, the accuracy is about 0.1 ul to about 0.2 ul, about 0.1 ul to about 0.5 ul, about 0.1 ul to about 1 ul, about 0.1 ul to about 2 ul, about 0.1 ul to about 3 ul, about 0.1 ul to about 4 ul, about 0.1 ul to about 5 ul, about 0.1 ul to about 6 ul, about 0.1 ul to about 7 ul, about 0.1 ul to about 8 ul, about 0.1 ul to about 10 ul, about 0.2 ul to about 0.5 ul, about 0.2 ul to about 1 ul, about 0.2 ul to about 2 ul, about 0.2 ul to about 3 ul, about 0.2 ul to about 4 ul, about 0.2 ul to about 5 ul, about 0.2 ul to about 6 ul, about 0.2 ul to about 7 ul, about 0.2 ul to about 8 ul, about 0.2 ul to about 10 ul, about 0.5 ul to about 1 ul, about 0.5 ul to about 2 ul, about 0.5 ul to about 3 ul, about 0.5 ul to about 4 ul, about 0.5 ul to about 5 ul, about 0.5 ul to about 6 ul, about 0.5 ul to about 7 ul, about 0.5 ul to about 8 ul, about 0.5 ul to about 10 ul, about 1 ul to about 2 ul, about 1 ul to about 3 ul, about 1 ul to about 4 ul, about 1 ul to about 5 ul, about 1 ul to about 6 ul, about 1 ul to about 7 ul, about 1 ul to about 8 ul, about 1 ul to about 10 ul, about 2 ul to about 3 ul, about 2 ul to about 4 ul, about 2 ul to about 5 ul, about 2 ul to about 6 ul, about 2 ul to about 7 ul, about 2 ul to about 8 ul, about 2 ul to about 10 ul, about 3 ul to about 4 ul, about 3 ul to about 5 ul, about 3 ul to about 6 ul, about 3 ul to about 7 ul, about 3 ul to about 8 ul, about 3 ul to about 10 ul, about 4 ul to about 5 ul, about 4 ul to about 6 ul, about 4 ul to about 7 ul, about 4 ul to about 8 ul, about 4 ul to about 10 ul, about 5 ul to about 6 ul, about 5 ul to about 7 ul, about 5 ul to about 8 ul, about 5 ul to about 10 ul, about 6 ul to about 7 ul, about 6 ul to about 8 ul, about 6 ul to about 10 ul, about 7 ul to about 8 ul, about 7 ul to about 10 ul, or about 8 ul to about 10 ul. In some embodiments, the accuracy is about 0.1 ul, about 0.2 ul, about 0.5 ul, about 1 ul, about 2 ul, about 3 ul, about 4 ul, about 5 ul, about 6 ul, about 7 ul, about 8 ul, or about 10 ul. 
     In some embodiments, the first hyperacuity target and the second hyperacuity target further extend towards each other to form a hyperacuity target separation gap between a first proximal point on the first hyperacuity target and a second proximal point on the second hyperacuity target. In some embodiments, the hyperacuity target separation gap is about 2 mm to about 60 mm. In some embodiments, the hyperacuity target separation gap is at least about 2 mm. In some embodiments, the distal edge of the first hyperacuity target and the distal edge of the second hyperacuity target are generally parallel or collinear. 
     In some embodiments, the dispensing measurement distance is about 1 mm to about 15 mm. In some embodiments, the dispensing measurement distance is at least about 1 mm. In some embodiments, the dispensing measurement distance is at most about 15 mm. In some embodiments, the dispensing measurement distance is about 1 mm to about 2 mm, about 1 mm to about 3 mm, about 1 mm to about 4 mm, about 1 mm to about 5 mm, about 1 mm to about 6 mm, about 1 mm to about 7 mm, about 1 mm to about 8 mm, about 1 mm to about 10 mm, about 1 mm to about 12 mm, about 1 mm to about 15 mm, about 2 mm to about 3 mm, about 2 mm to about 4 mm, about 2 mm to about 5 mm, about 2 mm to about 6 mm, about 2 mm to about 7 mm, about 2 mm to about 8 mm, about 2 mm to about 10 mm, about 2 mm to about 12 mm, about 2 mm to about 15 mm, about 3 mm to about 4 mm, about 3 mm to about 5 mm, about 3 mm to about 6 mm, about 3 mm to about 7 mm, about 3 mm to about 8 mm, about 3 mm to about 10 mm, about 3 mm to about 12 mm, about 3 mm to about 15 mm, about 4 mm to about 5 mm, about 4 mm to about 6 mm, about 4 mm to about 7 mm, about 4 mm to about 8 mm, about 4 mm to about 10 mm, about 4 mm to about 12 mm, about 4 mm to about 15 mm, about 5 mm to about 6 mm, about 5 mm to about 7 mm, about 5 mm to about 8 mm, about 5 mm to about 10 mm, about 5 mm to about 12 mm, about 5 mm to about 15 mm, about 6 mm to about 7 mm, about 6 mm to about 8 mm, about 6 mm to about 10 mm, about 6 mm to about 12 mm, about 6 mm to about 15 mm, about 7 mm to about 8 mm, about 7 mm to about 10 mm, about 7 mm to about 12 mm, about 7 mm to about 15 mm, about 8 mm to about 10 mm, about 8 mm to about 12 mm, about 8 mm to about 15 mm, about 10 mm to about 12 mm, about 10 mm to about 15 mm, or about 12 mm to about 15 mm. In some embodiments, the dispensing measurement distance is about 1 mm, about 2 mm, about 3 mm, about 4 mm, about 5 mm, about 6 mm, about 7 mm, about 8 mm, about 10 mm, about 12 mm, or about 15 mm. 
     In some embodiments, the product tube comprises comprising plastic, wood, metal, fiberglass, carbon fiber, resin, or any combination thereof. 
     Another aspect provided herein is a system for precise secretion of a semi-solid product comprising: a product tube having a shoulder and a dispensing tip; and a dispenser comprising: a collar comprising: an aperture configured to accept the dispensing tip; a proximal surface configured to contact the shoulder of the product tube; and a first surface generally perpendicular to the proximal surface, wherein the first surface comprises at least one hyperacuity target extending from the proximal surface by a dispensing measurement distance; wherein at least one of the first hyperacuity target and the second hyperacuity target provide a visual indication corresponding to the dispensing measurement distance and a secreted volume of the semi-solid product. 
     In some embodiments, the at least one hyperacuity target comprises a first hyperacuity target and a second hyperacuity target. 
     In some embodiments, the secreted volume is about 1 ul (microliter) to about 10 ul. In some embodiments, the secreted volume is at least about 1 ul. In some embodiments, the secreted volume is at most about 10 ul. In some embodiments, the secreted volume is about 1 ul to about 2 ul, about 1 ul to about 3 ul, about 1 ul to about 4 ul, about 1 ul to about 5 ul, about 1 ul to about 6 ul, about 1 ul to about 7 ul, about 1 ul to about 8 ul, about 1 ul to about 9 ul, about 1 ul to about 10 ul, about 2 ul to about 3 ul, about 2 ul to about 4 ul, about 2 ul to about 5 ul, about 2 ul to about 6 ul, about 2 ul to about 7 ul, about 2 ul to about 8 ul, about 2 ul to about 9 ul, about 2 ul to about 10 ul, about 3 ul to about 4 ul, about 3 ul to about 5 ul, about 3 ul to about 6 ul, about 3 ul to about 7 ul, about 3 ul to about 8 ul, about 3 ul to about 9 ul, about 3 ul to about 10 ul, about 4 ul to about 5 ul, about 4 ul to about 6 ul, about 4 ul to about 7 ul, about 4 ul to about 8 ul, about 4 ul to about 9 ul, about 4 ul to about 10 ul, about 5 ul to about 6 ul, about 5 ul to about 7 ul, about 5 ul to about 8 ul, about 5 ul to about 9 ul, about 5 ul to about 10 ul, about 6 ul to about 7 ul, about 6 ul to about 8 ul, about 6 ul to about 9 ul, about 6 ul to about 10 ul, about 7 ul to about 8 ul, about 7 ul to about 9 ul, about 7 ul to about 10 ul, about 8 ul to about 9 ul, about 8 ul to about 10 ul, or about 9 ul to about 10 ul. In some embodiments, the secreted volume is about 1 ul, about 2 ul, about 3 ul, about 4 ul, about 5 ul, about 6 ul, about 7 ul, about 8 ul, about 9 ul, or about 10 ul. 
     In some embodiments, the secreted amount is about 1 mg (milligram) to about 10 mg. In some embodiments, the secreted amount is at least about 1 mg. In some embodiments, the secreted amount is at most about 10 mg. In some embodiments, the secreted amount is about 1 mg to about 2 mg, about 1 mg to about 3 mg, about 1 mg to about 4 mg, about 1 mg to about 5 mg, about 1 mg to about 6 mg, about 1 mg to about 7 mg, about 1 mg to about 8 mg, about 1 mg to about 9 mg, about 1 mg to about 10 mg, about 2 mg to about 3 mg, about 2 mg to about 4 mg, about 2 mg to about 5 mg, about 2 mg to about 6 mg, about 2 mg to about 7 mg, about 2 mg to about 8 mg, about 2 mg to about 9 mg, about 2 mg to about 10 mg, about 3 mg to about 4 mg, about 3 mg to about 5 mg, about 3 mg to about 6 mg, about 3 mg to about 7 mg, about 3 mg to about 8 mg, about 3 mg to about 9 mg, about 3 mg to about 10 mg, about 4 mg to about 5 mg, about 4 mg to about 6 mg, about 4 mg to about 7 mg, about 4 mg to about 8 mg, about 4 mg to about 9 mg, about 4 mg to about 10 mg, about 5 mg to about 6 mg, about 5 mg to about 7 mg, about 5 mg to about 8 mg, about 5 mg to about 9 mg, about 5 mg to about 10 mg, about 6 mg to about 7 mg, about 6 mg to about 8 mg, about 6 mg to about 9 mg, about 6 mg to about 10 mg, about 7 mg to about 8 mg, about 7 mg to about 9 mg, about 7 mg to about 10 mg, about 8 mg to about 9 mg, about 8 mg to about 10 mg, or about 9 mg to about 10 mg. In some embodiments, the secreted amount is about 1 mg, about 2 mg, about 3 mg, about 4 mg, about 5 mg, about 6 mg, about 7 mg, about 8 mg, about 9 mg, or about 10 mg. 
     In some embodiments, an accuracy of the secreted volume is about 0.1 ul to about 10 ul. In some embodiments, the accuracy is at least about 0.1 ul. In some embodiments, the accuracy is at most about 10 ul. In some embodiments, the accuracy is about 0.1 ul to about 0.2 ul, about 0.1 ul to about 0.5 ul, about 0.1 ul to about 1 ul, about 0.1 ul to about 2 ul, about 0.1 ul to about 3 ul, about 0.1 ul to about 4 ul, about 0.1 ul to about 5 ul, about 0.1 ul to about 6 ul, about 0.1 ul to about 7 ul, about 0.1 ul to about 8 ul, about 0.1 ul to about 10 ul, about 0.2 ul to about 0.5 ul, about 0.2 ul to about 1 ul, about 0.2 ul to about 2 ul, about 0.2 ul to about 3 ul, about 0.2 ul to about 4 ul, about 0.2 ul to about 5 ul, about 0.2 ul to about 6 ul, about 0.2 ul to about 7 ul, about 0.2 ul to about 8 ul, about 0.2 ul to about 10 ul, about 0.5 ul to about 1 ul, about 0.5 ul to about 2 ul, about 0.5 ul to about 3 ul, about 0.5 ul to about 4 ul, about 0.5 ul to about 5 ul, about 0.5 ul to about 6 ul, about 0.5 ul to about 7 ul, about 0.5 ul to about 8 ul, about 0.5 ul to about 10 ul, about 1 ul to about 2 ul, about 1 ul to about 3 ul, about 1 ul to about 4 ul, about 1 ul to about 5 ul, about 1 ul to about 6 ul, about 1 ul to about 7 ul, about 1 ul to about 8 ul, about 1 ul to about 10 ul, about 2 ul to about 3 ul, about 2 ul to about 4 ul, about 2 ul to about 5 ul, about 2 ul to about 6 ul, about 2 ul to about 7 ul, about 2 ul to about 8 ul, about 2 ul to about 10 ul, about 3 ul to about 4 ul, about 3 ul to about 5 ul, about 3 ul to about 6 ul, about 3 ul to about 7 ul, about 3 ul to about 8 ul, about 3 ul to about 10 ul, about 4 ul to about 5 ul, about 4 ul to about 6 ul, about 4 ul to about 7 ul, about 4 ul to about 8 ul, about 4 ul to about 10 ul, about 5 ul to about 6 ul, about 5 ul to about 7 ul, about 5 ul to about 8 ul, about 5 ul to about 10 ul, about 6 ul to about 7 ul, about 6 ul to about 8 ul, about 6 ul to about 10 ul, about 7 ul to about 8 ul, about 7 ul to about 10 ul, or about 8 ul to about 10 ul. In some embodiments, the accuracy is about 0.1 ul, about 0.2 ul, about 0.5 ul, about 1 ul, about 2 ul, about 3 ul, about 4 ul, about 5 ul, about 6 ul, about 7 ul, about 8 ul, or about 10 ul. 
     In some embodiments, the first hyperacuity target and the second hyperacuity target further extend towards each other to form a hyperacuity target separation gap between a first proximal point on the first hyperacuity target and a second proximal point on the second hyperacuity target. In some embodiments, the hyperacuity target separation gap is about 2 mm to about 60 mm. In some embodiments, the hyperacuity target separation gap is at least about 2 mm. In some embodiments, a distal edge of at least one of the first hyperacuity target and the second hyperacuity target are generally perpendicular to the proximal surface. In some embodiments, the distal edge of the first hyperacuity target and the distal edge of the second hyperacuity target are generally parallel or collinear. In some embodiments, the dispensing measurement distance is a greater than a distance from the shoulder of the semi-solid product tube to a distal point of the dispensing tip. 
     In some embodiments, the dispensing measurement distance is about 1 mm to about 15 mm. In some embodiments, the dispensing measurement distance is at least about 1 mm. In some embodiments, the dispensing measurement distance is at most about 15 mm. In some embodiments, the dispensing measurement distance is about 1 mm to about 2 mm, about 1 mm to about 3 mm, about 1 mm to about 4 mm, about 1 mm to about 5 mm, about 1 mm to about 6 mm, about 1 mm to about 7 mm, about 1 mm to about 8 mm, about 1 mm to about 10 mm, about 1 mm to about 12 mm, about 1 mm to about 15 mm, about 2 mm to about 3 mm, about 2 mm to about 4 mm, about 2 mm to about 5 mm, about 2 mm to about 6 mm, about 2 mm to about 7 mm, about 2 mm to about 8 mm, about 2 mm to about 10 mm, about 2 mm to about 12 mm, about 2 mm to about 15 mm, about 3 mm to about 4 mm, about 3 mm to about 5 mm, about 3 mm to about 6 mm, about 3 mm to about 7 mm, about 3 mm to about 8 mm, about 3 mm to about 10 mm, about 3 mm to about 12 mm, about 3 mm to about 15 mm, about 4 mm to about 5 mm, about 4 mm to about 6 mm, about 4 mm to about 7 mm, about 4 mm to about 8 mm, about 4 mm to about 10 mm, about 4 mm to about 12 mm, about 4 mm to about 15 mm, about 5 mm to about 6 mm, about 5 mm to about 7 mm, about 5 mm to about 8 mm, about 5 mm to about 10 mm, about 5 mm to about 12 mm, about 5 mm to about 15 mm, about 6 mm to about 7 mm, about 6 mm to about 8 mm, about 6 mm to about 10 mm, about 6 mm to about 12 mm, about 6 mm to about 15 mm, about 7 mm to about 8 mm, about 7 mm to about 10 mm, about 7 mm to about 12 mm, about 7 mm to about 15 mm, about 8 mm to about 10 mm, about 8 mm to about 12 mm, about 8 mm to about 15 mm, about 10 mm to about 12 mm, about 10 mm to about 15 mm, or about 12 mm to about 15 mm. In some embodiments, the dispensing measurement distance is about 1 mm, about 2 mm, about 3 mm, about 4 mm, about 5 mm, about 6 mm, about 7 mm, about 8 mm, about 10 mm, about 12 mm, or about 15 mm. 
     In some embodiments, the product tube further comprises a cap, and wherein the aperture is further configured to accept the cap. In some embodiments, the aperture has a diameter of about 3 mm to about 50 mm. In some embodiments, the aperture has a diameter of at least about 3 mm. In some embodiments, the first surface further comprises a cavity configured surround at least a portion of the product tube. In some embodiments, the aperture of the collar comprises a threaded feature. In some embodiments, the dispenser comprises plastic, wood, metal, fiberglass, carbon fiber, resin, or any combination thereof. 
     Another aspect provided herein is a kit comprising: two or more product tubes containing a semi-solid product, each product tube having a semi-solid product; and a dispenser. In some embodiments, the kit further comprises at least one of an applicator, an instruction manual, a mirror, and a wipe. 
     Another aspect provided herein is a method for precise secretion of a semi-solid product comprising: providing a product tube having a shoulder and a dispensing tip; providing a dispenser; aligning the shoulder of the product tube against the proximal surface of the dispenser; and compressing the product tube to secrete the semi-solid product until the semi-solid product is level with a proximal portion of the first hyperacuity target, a proximal portion of the second hyperacuity target, or both. In some embodiments, the method further comprises removing the secreted semi-solid product from the product tube. In some embodiments, removing the secreted semi-solid product from the product tube comprises removing the secreted semi-solid product from the product tube with an applicator or a finger. In some embodiments, the method further comprises applying the semi-solid product to a patient. In some embodiments, the product tube further comprises a cap, and wherein the method further comprises removing the cap. In some embodiments, the cap is removed before inserting the dispensing tip of the product tube within the aperture of the dispenser. In some embodiments, the cap is removed after inserting the dispensing tip of the product tube within the aperture of the dispenser. In some embodiments, the method further comprises replacing the cap onto the product tube after removing the secreted semi-solid product from the product tube. 
     Another aspect provided herein is a method for precise secretion of a semi-solid product comprising: providing a product tube; and compressing the product tube to secrete the semi-solid product until the semi-solid product is level with a proximal portion of the first hyperacuity target, a proximal portion of the second hyperacuity target, or both. 
     In some embodiments, the method further comprises removing the secreted semi-solid product from the product tube. In some embodiments, removing the secreted semi-solid product from the product tube comprises removing the secreted semi-solid product from the product tube with an applicator or a finger. In some embodiments, the method further comprises applying the semi-solid to a patient. In some embodiments, the product tube further comprises a cap, and wherein the method further comprises removing the cap. In some embodiments, the method further comprises replacing the cap onto the product tube after removing the secreted semi-solid product from the product tube. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       The novel features of the disclosure are set forth with particularity in the appended claims. A better understanding of the features and advantages of the present disclosure will be obtained by reference to the following detailed description that sets forth illustrative embodiments, in which the principles of the disclosure are utilized, and the accompanying drawings of which: 
         FIG. 1  is a front view illustration of an exemplary (e.g., first) dispenser, per some embodiments herein; 
         FIG. 2  is a top view illustration of an exemplary (e.g., first) dispenser, per some embodiments herein; 
         FIG. 3  is a front view illustration of an exemplary (e.g., second) dispenser(e.g., comprising a recess), per some embodiments herein; 
         FIG. 4  is a front view illustration of an exemplary (e.g., first) semi solid product tube, per some embodiments herein; 
         FIG. 5  is a front view illustration of an exemplary (e.g., first) system comprising a semi solid product dispenser and a product tube, per some embodiments herein; 
         FIG. 6  is an image of an exemplary (e.g., first) system comprising a semi solid product dispenser and a product tube, per some embodiments herein; 
         FIG. 7  is another image of an exemplary (e.g., first) system comprising a semi solid product dispenser and a product tube, per some embodiments herein; 
         FIG. 8  is an image of an exemplary (e.g., first) system comprising a semi solid product dispenser and a product tube, per some embodiments herein; 
         FIG. 9  is a front view illustration of an exemplary (e.g., second) dispenser, per some embodiments herein; 
         FIG. 10  is a perspective view illustration of an exemplary (e.g., second) dispenser, per some embodiments herein; 
         FIG. 11  is a perspective view illustration of an exemplary (e.g., second) dispenser, per some embodiments herein; 
         FIG. 12  is a top view illustration of an exemplary (e.g., second) dispenser, per some embodiments herein; 
         FIG. 13  is a side view illustration of an exemplary (e.g., second) dispenser, per some embodiments herein; 
         FIG. 14  is a front view illustration of an exemplary (e.g., third) dispenser, per some embodiments herein; 
         FIG. 15  is a front view illustration of an exemplary (e.g., fourth) dispenser, per some embodiments herein; 
         FIG. 16  is a front view illustration of an exemplary (e.g., second) semi solid product tube, per some embodiments herein; 
         FIG. 17  is an exploded front view illustration of the exemplary (e.g., second) semi solid product tube comprising a cap, per some embodiments herein; 
         FIG. 18  is a collapsed front view illustration of the exemplary (e.g., second) semi solid product tube, per some embodiments herein; 
         FIG. 19  is a top view illustration of the exemplary (e.g., second) semi solid product tube, per some embodiments herein; 
         FIG. 20  is a side view illustration of the exemplary (e.g., second) semi solid product tube, per some embodiments herein; 
         FIG. 21  is a top view illustration of an exemplary (e.g., third) semi solid product tube, per some embodiments herein; 
         FIG. 22  is a top view illustration of an exemplary (e.g., fourth) semi solid product tube, per some embodiments herein; 
         FIG. 23  is a front view illustration of an exemplary (e.g., first) system comprising a semi solid product dispenser and a product tube, per some embodiments herein; 
         FIG. 24  is a front exploded view illustration of an exemplary (e.g., first) system, per some embodiments herein; 
         FIG. 25  is a front collapsed view illustration of an exemplary (e.g., first) system, per some embodiments herein; 
         FIG. 26  is a front view illustration of an exemplary (e.g., second) system comprising a semi solid product dispenser and a product tube, per some embodiments herein; and 
         FIG. 27  is a front view illustration of an exemplary (e.g., third) system comprising a semi solid product dispenser and a product tube, per some embodiments herein. 
     
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     While eye drops have been used to dispense controlled liquid volumes of a medicament, such devices are incapable of properly dispensing semi-solid drugs or cosmetic products. Further, such eye drops exhibit poor accuracies, whereby the liquid volume per drop may range from 30-50 microliters, and whereby the number of dispensed drops cannot be easily controlled. Additionally, inhalers and syringes have been developed for dosing aqueous medicaments through controlled dosing orifice sizes and timed control. Such solutions, however, may not be configured for proper dispensing of semi-solid products, gels, ointments, or creams. 
     Accurate dosing of small amounts of semi-solid products has been difficult to achieve due to the high viscosity and non-Newtonian aspects of such semi-solids. Further, as such dosing mechanisms are currently large and expensive, their use for the treatment of temporary conditions, or for short-term clinical trials are limited. Excessive application of many semi-solid products may cause unwanted side-effects. For example, excessive application of eye products may blur vision by creating thick layers that mixes into the tear film. Insufficient application of many products may slow or prevent proper treatment. Additionally, controlled dispensed volumes may further improve the application accuracy for proper treatment. For example, excessive eye medicament applied to the eye may be accidentally applied to the eye-lid margin. Finally, many such medicaments are sensitive to dirt, particulate, and oils, and must be transferred directly to the treatment site without contact with non-applicator surfaces, to avoid contamination. 
     Many semi-solid products are stored and dispensed from product tubes, which are often improper for accurate dosing. As such product tubes may be formed of metal, plastic, or both, the internal dispensing pressure may continue or reverse once the force applied by the user terminates. 
     As such, provided herein are intuitive, cost-effective dispensing aids, systems, and method which enable accurately control the semi-solid product dosing. 
     Dispenser for precise secretion of a semi-solid product from a product tube 
     Described herein, per  FIGS. 1-3 , is an exemplary (e.g., first) dispenser 100 for precise secretion of a semi-solid product from a product tube (not shown). In various embodiments, the semi-solid is an ointment, a cream, or a gel, or other suitable formulation. 
     In some embodiments, the product tube has a shoulder and a dispensing tip. In some embodiments, the product tube further comprises a cap. 
     The first dispenser  100  may comprise a collar  110  and a first surface  120 . The collar  110  may comprise an aperture  112  and a proximal surface  111  (e.g., proximal to a receiving end of aperture  112 , such as for receiving a product tube, or tip thereof, therethrough). The aperture  112  may be configured to accept the dispensing tip (e.g., through the receiving end thereof, such as configured proximal to the proximal surface  111 ). The aperture  112  may be configured to accept the cap. The proximal surface  111  may be configured to contact the shoulder of the product tube. In some embodiments, the aperture  112  has a diameter  113  of about 3 mm to about 50 mm. In some embodiments, the aperture  112  has a diameter  113  of at least about 3 mm. The aperture diameter  113  may be measured as a minimum aperture diameter  113 , or an average aperture diameter  113 . In some embodiments, the aperture  112  of the collar  110  comprises a threaded feature. In some embodiments, the first dispenser  100  comprises plastic, wood, metal, fiberglass, carbon fiber, resin, or any combination thereof. 
     In certain embodiments, a dispenser provided herein comprises a first surface  120 , such as wherein the first surface  120  may be generally perpendicular to the proximal surface  111 . The first surface  120  may comprise at least one hyperacuity target  130 ,  140 . The at least one hyperacuity target  130 ,  140  may comprise a first hyperacuity target  130  and a second hyperacuity target  140 . In some embodiments, a distal edge of at least one of the first hyperacuity target  130  and the second hyperacuity target  140  are generally perpendicular to the proximal surface  111 . In some embodiments, the distal edge of the first hyperacuity target  130  and the distal edge of the second hyperacuity target  140  are generally parallel or collinear. At least one of the first hyperacuity target  130  and the second hyperacuity target  140  may provide a visual indication corresponding to the dispensing measurement distance and a secreted volume of the semi-solid product. At least one of the first hyperacuity target  130  and the second hyperacuity target  140  may provide a visual indication corresponding to the dispensing measurement distance and a secreted amount or dosage of the semi-solid product. The at least one hyperacuity target  130 ,  140  may terminate at a set distance from the nozzle of the product tube to prevent contact between the at least one hyperacuity target  130 ,  140  and the semi-solid product. Preventing contact may enable sterility of the semi-solid product. 
     The visual indication may comprise a hyperacuity visual indication, wherein a human eye automatically employs Vernier acuity to identify a very small misalignment between two or more visual stimuli (such as two lines segments). This Vernier acuity of the human eye has been shown to be able to discriminate misalignment of 3-6 sec arc. As this phenomenon enables sensitivity of an order of magnitude greater than visual acuity (the smallest number or letter human eye can recognize) hyperacuity may be implemented to enable simple and precise alignment measurements. 
     In some embodiments, the first hyperacuity target  130  and the second hyperacuity target  140  further extend towards each other. In some embodiments, the first hyperacuity target  130  and the second hyperacuity target  140  further extend towards each other to form a hyperacuity target separation gap  160 . The separation gap  160  may be measured between a first proximal point and a second proximal point. The separation gap  160  may be measured as a minimum distance between the first proximal point  131  on the first hyperacuity target  130  and the second proximal point  141  on the second hyperacuity target  140 . The separation gap  160  may be measured as a minimum normal distance between the first proximal point  131  on the first hyperacuity target  130  and the second proximal point  141  on the second hyperacuity target  140 . The separation gap  160  may be measured as a minimum normal distance between the first hyperacuity target  130  and the second hyperacuity target  140 . In some embodiments, the hyperacuity target separation gap  160  is about 2 mm to about 60 mm. In some embodiments, the hyperacuity target separation gap  160  is at least about 2 mm. The separation gap may be designed to prevent contact between the first hyperacuity target  130  and the semi-solid product, the second hyperacuity target  140  and the semi-solid product, or both. Preventing contact may enable sterility of the semi-solid product. 
     The first hyperacuity target  130  may extend from the proximal surface  111  by a dispensing offset length  150 . The second hyperacuity target  140  may extend from the proximal surface  111  by the dispensing offset length  150 . In some embodiments, the dispensing offset length  150  is a greater than a distance from the shoulder of the product tube to a distal point of the dispensing tip. In some embodiments, the dispensing offset length  150  is about 1 mm to about 100 mm. In some embodiments, the dispensing offset length  150  is at least about 1 mm. The dispensing offset length  150  may be measured as a maximum distance between the proximal surface  111  and a first distal point on the first hyperacuity target  130  or a second distal point on the second hyperacuity target  140 . The dispensing offset length  150  may be measured as a maximum normal distance between the proximal surface  111  and the first distal point on the first hyperacuity target  130  or the second distal point on the second hyperacuity target  140 . In some embodiments, the first distal point is the first proximal point  131 . In some embodiments, the second distal point is the second proximal point  141 . In some embodiments, the dispensing offset length  150  corresponds to the secreted volume of the semi-solid product. In some embodiments, the secreted volume is about 1 ul to about 10 ul. In some embodiments, the secreted volume is about 1 mg to about 10 mg. In some embodiments, the secreted volume accuracy is about 0.1 ul to about 10 ul. In some embodiments, the secreted volume corresponds to a viscosity, a melting temperature, a kinematic viscosity, or any combination thereof of the semi-solid product. 
     An exemplary second dispenser  300  is shown in  FIG. 3 , wherein the first surface  120  further comprises a recess  370  configured to receive and/or surround at least a portion of the product tube. As shown, in some instances, the recess  370  is tapered. Alternatively, in some embodiments, the recess  370  has a planar shape comprising a circle, a square, or any polygon. Various embodiments of the dispenser  300  is further illustrated in  FIGS. 9-13  wherein dispenser  300  comprises a tube fastener  910 . As shown, the tube fastener  910  comprises a ledge. Alternatively in some embodiments, the tube fastener  910  comprises a clip, a channel, or any other element configured to releasably constrain a product tube. 
     Moreover,  FIGS. 10-13  illustrate further three dimensional representations of other aspects of exemplary dispensers described herein (e.g., such as in  FIGS. 1-3 ). For example,  FIG. 10  illustrates a view of an exemplary device from above, viewed along the first surface, directed at the proximal surface, and into and through the aperture.  FIG. 11  illustrates a view of an exemplary device from above and from the direction of the hyperacuity target(s) into and through the aperture from the direction opposite the proximal surface of the collar.  FIG. 12  illustrates a view of an exemplary device from the end of the device past the hyperacuity target(s) and into and through the aperature (from the side opposite the proximal surface).  FIG. 13  illustrates a side view of an exemplary device comprising a recess within the first surface. 
       FIG. 14  shows an exemplary dispenser  1400  comprising a single hyperacuity target  1440 , such as having a single indication feature  1441 (e.g., corresponding to a similar structure as a proximal point in other devices illustrated herein). As shown, in some instances, an upper surface of the single hyperacuity target  1440  is generally parallel with the collar  1411  of the dispenser  1400 .  FIG. 15  shows an exemplary dispenser  1500  comprising a single hyperacuity target  1540  having two indication features  1541 . Alternatively, in some embodiments, the dispenser comprises more than two indication features  1441   1541 . As shown, in some instances, an upper surface of a lower hyperacuity target  1540  is generally parallel with the collar  1411  of the dispenser  1400 , such as while a left (or right, depending on the side the hyperacuity target is configured) surface of an upper hyperacuity target  1540  is generally perpendicular to the collar  1411  of the third dispenser  1400 . 
     In some embodiments, the dispenser  100 ,  900 ,  1400 ,  1500  comprises a single-use dispenser. 
     Product tube for precise secretion of a semi-solid product 
     Another aspect provided herein, per  FIG. 4 , is an exemplary (e.g., semi-solid) product tube  400  for precise secretion of a semi-solid. The semi-solid may comprise an ointment, a cream, or a gel. In some instances, such a product tube is an integrated product comprising a dispenser, such as discussed herein, and a product tube, such as otherwise discussed herein. 
     In some embodiments, the (e.g., semi-solid) product tube  400  comprises a product tube body  420 , a nozzle  490 , and at least one hyperacuity target  430 ,  440 . The at least one hyperacuity target  430 ,  440  may comprise a first hyperacuity target  430  and a second hyperacuity target  440 . At least one of the first hyperacuity target  430  and the second hyperacuity target  440  may provide a visual indication corresponding to the dispensing measurement distance and a secreted volume of the semi-solid product. In some embodiments, the first semi-solid product tube  400  comprises a single-use product tube  400 . 
     The product tube body  420  may be configured to contain the semi-solid product. The nozzle  490  may be configured to secrete the semi-solid product from the product tube body  420 . The nozzle  490  may have an inner diameter. In some embodiments, the first semi-solid product tube  400  comprises comprising plastic, wood, metal, fiberglass, carbon fiber, resin, or any combination thereof. 
     In some embodiments, the first hyperacuity target  430  and the second hyperacuity target  440  further extend towards each other. In some embodiments, the first hyperacuity target  430  and the second hyperacuity target  440  further extend towards each other to form a hyperacuity target separation gap  460 . The separation gap  460  may be measured between a first proximal point and a second proximal point. The separation gap  460  may be measured as a minimum distance between the first proximal point  431  on the first hyperacuity target  430  and the second proximal point  441  on the second hyperacuity target  440 . The separation gap  460  may be measured as a minimum normal distance between the first proximal point  431  on the first hyperacuity target  430  and the second proximal point  441  on the second hyperacuity target  440 . The separation gap  460  may be measured as a minimum normal distance between the first hyperacuity target  430  and the second hyperacuity target  440 . In some embodiments, the hyperacuity target separation gap  460  is about 2 mm to about 60 mm. In some embodiments, the hyperacuity target separation gap  460  is at least about 2 mm. The at least one hyperacuity target  430 ,  440  may terminate at a set distance from the nozzle  490  of the product tube to prevent contact between the at least one hyperacuity target  430   440  and the semi-solid product. The separation gap may be designed to prevent contact between the first hyperacuity target  430  and the semi-solid product, the second hyperacuity target  440  and the semi-solid product, or both. 
     The first hyperacuity target  430  may extend from the nozzle  490  by a dispensing measurement distance  480 . The second hyperacuity target  440  may extend from the nozzle  490  by the dispensing measurement distance  480 . In some embodiments, the dispensing measurement distance  480  is a greater than a distance from the shoulder of the product tube to a distal point of the dispensing tip. In some embodiments, the dispensing measurement distance  480  is about 1 mm to about 15 mm. In some embodiments, the dispensing measurement distance  480  is about 1 mm to about 7 mm. In some embodiments, the dispensing measurement distance  480  is at least about 1 mm. The dispensing measurement distance  480  may be measured as a maximum distance between the nozzle  490  and a first distal point on the first hyperacuity target  430  or a second distal point on the second hyperacuity target  440 . The dispensing measurement distance  480  may be measured as a maximum normal distance between the nozzle  490  and the first distal point on the first hyperacuity target  430  or the second distal point on the second hyperacuity target  440 . In some embodiments, the first distal point is the first proximal point  431 . In some embodiments, the second distal point is the second proximal point  441 . In some embodiments, the dispensing measurement distance  480  corresponds to the secreted volume of the semi-solid product. In some embodiments, the secreted volume corresponds to a viscosity, a melting temperature, a kinematic viscosity, or any combination thereof of the semi-solid product. In some embodiments, the secreted volume (e.g., of any product tube, dispenser, or combination thereof) is about 1 ul to about 10 ul. In some embodiments, the secreted volume is about 1 mg to about 10 mg. In some embodiments, the secreted volume accuracy is about 0.1 ul to about 10 ul. In some embodiments, the secreted volume of the semi-solid product corresponds to the dispensing measurement distance (D)  480  and the inner diameter of the nozzle  490  (ID). In some embodiments, the secreted volume of the semi-solid product is equal to: 
     
       
         
           
             D 
             × 
             
               
                 π 
                  
                 
                   ( 
                   
                     ID 
                     2 
                   
                   ) 
                 
               
               2 
             
           
         
       
     
       FIGS. 16-20  show illustrations of an exemplary product tube  1600  (e.g., integrated product tube with dispenser and/or product tube input into a dispenser, such as described herein) comprising a first product tube body (or a dispenser body)  1610 , a second product tube body  1611 , and a nozzle  1620 . In some embodiments, such as illustrated in  FIGS. 17-18  the second semi-solid product tube  1600  further comprises a cap  1630 , which may be placed over the nozzle  1620  when the semi-solid is not being dispensed, such as illustrated in  FIG. 18 . The cap  1630  may be configured to cover and protect the nozzle  1620 . 
       FIG. 19  further illustrates a view of an exemplary (e.g,. integrated) product tube from the end of the product tube past the hyperacuity target(s) and into the nozzle of the product tube.  FIG. 20  illustrates a side view of an exemplary product tube integrated with hyperacuity target(s) and first product tube body  1610 . 
       FIG. 21  shows an illustration of an exemplary (e.g., integrated) (e.g., semi-solid) product tube  2100  comprising a first product tube (or dispenser body) body  2110 , a second product tube body  2111 , and a cap  1630  covering a nozzle, wherein the first product tube body  2110  comprises a single hyperacuity target  2150 .  FIG. 22  shows an illustration of an exemplary (e.g., integrated) (e.g., semi-solid) product tube  2200  comprising a first product tube body (or dispenser body)  2210 , a second product tube body  2211 , a nozzle  1620 , wherein the first product tube body  2210  comprises two hyperacuity targets  2250 . 
     In some embodiments, the cap  1630  removably attaches to the product tube body  1611 . In some embodiments, the cap  1630  removably attaches to the product tube body  1611  though a snap feature, a screw, a press fit, a hook and loop fastener, a tie, a sticker, or any combination thereof. 
     System for precise secretion of a semi-solid product 
     Another aspects provided herein, per  FIGS. 5-8 , are systems for precise secretion of a semi-solid product. 
     As shown in  FIG. 5 , the exemplary first system  500  for precise secretion of a semi-solid product comprises a product tube  510 , and a second dispenser  300 . In some embodiments, the product tube  510  has a shoulder  511  and a dispensing tip  512 . In some embodiments, the product tube  510  further comprises a cap. The semi-solid  530  may comprise an ointment, a cream, or a gel. 
     The second dispenser  300  may comprise a collar and a first surface comprising a first hyperacuity target and a second hyperacuity target. The collar may comprise an aperture and a proximal surface. The aperture may be configured to accept the dispensing tip  512 . The aperture may be configured to accept the cap. The proximal surface may be configured to contact the  512  of the product tube  510 . 
     In some embodiments, the first surface further comprises a cavity configured surround at least a portion of the product tube  510 . In some embodiments, the aperture of the collar comprises a threaded feature. In some embodiments, the second dispenser  300  comprises plastic, wood, metal, fiberglass, carbon fiber, resin, or any combination thereof. 
     At least one of the first hyperacuity target and the second hyperacuity target may provide a visual indication corresponding to the dispensing measurement distance and a secreted volume of the semi-solid product  530 . 
     The first hyperacuity target may extend from the proximal surface  511  by a dispensing offset length  550 . The second hyperacuity target may extend from the proximal surface  511  by the dispensing offset length  550 . In some embodiments, the dispensing offset length  550  is a greater than a distance from the shoulder of the product tube to a distal point of the dispensing tip. In some embodiments, the dispensing offset length  550  is about 1 mm to about 100 mm. In some embodiments, the dispensing offset length  550  is at least about 1 mm. The dispensing offset length  550  may be measured as a maximum distance between the proximal surface  511  and a first distal point on the first hyperacuity target or a second distal point on the second hyperacuity target. The dispensing offset length  550  may be measured as a maximum normal distance between the proximal surface  511  and the first distal point on the first hyperacuity target or the second distal point on the second hyperacuity target. In some embodiments, the first distal point is the first proximal point. In some embodiments, the second distal point is the second proximal point. In some embodiments, the dispensing offset length  550  corresponds to the secreted volume of the semi-solid product  530 . In some embodiments, the secreted volume is about 1 ul to about 10 ul. In some embodiments, the secreted volume is about 1 mg to about 10 mg. In some embodiments, the secreted volume accuracy is about 0.1 ul to about 10 ul. In some embodiments, the secreted volume corresponds to a viscosity, a melting temperature, a kinematic viscosity, or any combination thereof of the semi-solid product  530 . 
     The first hyperacuity target may extend from the nozzle by a dispensing measurement distance  580 . The second hyperacuity target may extend from the nozzle by the dispensing measurement distance  580 . In some embodiments, the dispensing measurement distance  580  is a greater than a distance  580  from the shoulder of the product tube to a distal point of the dispensing tip. In some embodiments, the dispensing measurement distance  580  is about 1 mm to about 15 mm. In some embodiments, the dispensing measurement distance  580  is at least about 1 mm. The dispensing measurement distance  580  may be measured as a maximum distance  580  between the nozzle and a first distal point on the first hyperacuity target or a second distal point on the second hyperacuity target. The dispensing measurement distance  580  may be measured as a maximum normal distance  580  between the nozzle and the first distal point on the first hyperacuity target or the second distal point on the second hyperacuity target. In some embodiments, the first distal point is the first proximal point. In some embodiments, the second distal point is the second proximal point. In some embodiments, the dispensing measurement distance  580  corresponds to the secreted volume of the semi-solid product  530 . In some embodiments, the secreted volume corresponds to a viscosity, a melting temperature, a kinematic viscosity, or any combination thereof of the semi-solid product  530 . In some embodiments, the secreted volume is about 1 ul to about 10 ul. In some embodiments, the secreted volume is about 1 mg to about 10 mg. In some embodiments, the secreted volume accuracy is about 0.1 ul to about 10 ul. In some embodiments, the secreted volume of the semi-solid product  530  corresponds to the dispensing measurement distance  580  (D) and the inner diameter of the nozzle (ID). In some embodiments, the secreted volume of the semi-solid product  530  is equal to: 
     
       
         
           
             D 
             × 
             
               
                 π 
                  
                 
                   ( 
                   
                     ID 
                     2 
                   
                   ) 
                 
               
               2 
             
           
         
       
     
       FIGS. 6-7  show images of the exemplary system  500  for precise secretion of a semi-solid product.  FIG. 8  shows an image of the insertion of the product tube  510  into the second dispenser  300  of the exemplary system  500  for precise secretion of a semi-solid product. 
       FIGS. 23-25  display illustrations of the exemplary first system  500   2300  comprising a semi-solid product dispenser  300  and a product tube  510 . Per  FIGS. 24-25 , in some embodiments, the system  500  further comprises a cap  1630 . The cap  1630  may be configured to cover and protect a nozzle of the product tube  510 . 
       FIG. 26  is a front view illustration of an exemplary second system  2600  comprising the third solid product dispenser  1400 , a product tube  510 , and a cap  1630  covering the nozzle of the a product tube  510 .  FIG. 27  is a front view illustration of an exemplary system  2700  comprising the fourth solid product dispenser  1500 , a product tube  510 , and a cap  1630  covering the nozzle of the a product tube  510 . 
     In some embodiments, the cap  1630  removably attaches to the product tube  510 . In some embodiments, the cap  1630  removably attaches to the product tube  510  though a snap feature, a screw, a press fit, a hook and loop fastener, a tie, a sticker, or any combination thereof. 
     Semi-solid product dispensing kits 
     Another aspect provided herein is a kit comprising two or more product tubes, each product tube having a product and a dispenser. Each of the two or more semi-solid product tubes may comprise the same semi-solid product or different semi-solid products. In some embodiments, the kit further comprises an applicator. The applicator may comprise at least one of a Q-tip, a swab, a tissue, and a brush. In some embodiments, the kit further comprises an at least one of an instruction manual, a mirror and a wipe. The wipe may comprise one or more of a tissue, a towel, a paper, and a q-tip and a brush. 
     Methods for precise secretion of a semi-solid product 
     Provided herein is a first method for precise secretion of a semi-solid product comprising: providing a product tube; inserting the dispensing tip of the product tube within the aperture of the dispenser; aligning the shoulder of the product tube against the proximal surface of the dispenser; and compressing the product tube to secrete the semi-solid product until the semi-solid product is level with a proximal portion of the first hyperacuity target, a proximal portion of the second hyperacuity target, or both. 
     In some embodiments, the method further comprises removing the secreted semi-solid product from the product tube. In some embodiments, removing the secreted semi-solid product from the product tube comprises removing the secreted semi-solid product from the product tube with an applicator or a finger. In some embodiments, the method further comprises applying the semi-solid product to a patient. In some embodiments, the product tube further comprises a cap, and wherein the method further comprises removing the cap. In some embodiments, the cap is removed before inserting the dispensing tip of the product tube within the aperture of the dispenser. In some embodiments, the cap is removed after inserting the dispensing tip of the product tube within the aperture of the dispenser. In some embodiments, the method further comprises replacing the cap onto the product tube after removing the secreted semi-solid product from the product tube. In some embodiments, the semi-solid product generally maintains its cylindrical shape once it is secreted from the nozzle of the product tube. 
     Also provided herein is a second method for precise secretion of a semi-solid product comprising: providing a product tube; and compressing the product tube to secrete the semi-solid product until the semi-solid product is level with a proximal portion of the first hyperacuity target, a proximal portion of the second hyperacuity target, or both. 
     In some embodiments, the method further comprises removing the secreted semi-solid product from the product tube. In some embodiments, removing the secreted semi-solid product from the product tube comprises removing the secreted semi-solid product from the product tube with an applicator or a finger. In some embodiments, the method further comprises applying the semi-solid product to a patient. In some embodiments, the product tube further comprises a cap, and wherein the method further comprises removing the cap. In some embodiments, the method further comprises replacing the cap onto the product tube after removing the secreted semi-solid product from the product tube. In some embodiments, the semi-solid product generally maintains its cylindrical shape once it is secreted from the nozzle of the product tube. 
     TERMS AND DEFINITIONS 
     Unless otherwise defined, all technical terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs. 
     As used herein, the singular forms “a,” “an,” and “the” include plural references unless the context clearly dictates otherwise. Any reference to “or” herein is intended to encompass “and/or” unless otherwise stated. 
     As used herein, the term “generally” refers to an amount that is identical to the stated amount or near the stated amount by 15 degrees, 10 degrees, 5, degrees, or 1 degree, including increments therein. 
     As used herein, the term “about” refers to an amount that is near the stated amount by 10%, 5%, or 1%, including increments therein. 
     As used herein, the phrases “at least one”, “one or more”, and “and/or” are open-ended expressions that are both conjunctive and disjunctive in operation. For example, each of the expressions “at least one of A, B and C”, “at least one of A, B, or C”, “one or more of A, B, and C”, “one or more of A, B, or C” and “A, B, and/or C” means A alone, B alone, C alone, A and B together, A and C together, B and C together, or A, B and C together. 
     While preferred embodiments of the present disclosure have been shown and described herein, it will be obvious to those skilled in the art that such embodiments are provided by way of example only. Numerous variations, changes, and substitutions will now occur to those skilled in the art without departing from the disclosure. It should be understood that various alternatives to the embodiments of the disclosure described herein may be employed in practicing the disclosure. 
     EXAMPLES 
     Example 1 
     Dispensing Repeatability 
     The relationship between ointment weight and volume was measured at 5 microliter=4.5 mg. As such to dispense 4.5 mg of an exemplary ophthalmic ointment from a tube tip having an internal diameter of 1.27 mm, the dispenser was configured to extrude a 5 microliter sample having a length of about 4 mm. 
     To evaluate the repeatability of an ophthalmic product amount (mg) dispensed from the dispenser, two subjects dispensed an amount of 4 mg of a product from a product tube using the dispenser described herein. The dispensed amount was weighed per Tables 1 and 2 below: 
     
       
         
           
               
               
               
             
               
                   
                 TABLE 1 
               
               
                   
                   
               
               
                   
                 Subject 
                 Amount Dispensed (mg) 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                 1 
                 4.6 
               
               
                   
                 1 
                 4.3 
               
               
                   
                 1 
                 4.6 
               
               
                   
                 1 
                 4.8 
               
               
                   
                 1 
                 4.1 
               
               
                   
                 1 
                 4.6 
               
               
                   
                 1 
                 5.9 
               
               
                   
                 1 
                 4.7 
               
               
                   
                 1 
                 5 
               
               
                   
                 2 
                 5.3 
               
               
                   
                 2 
                 4.6 
               
               
                   
                 2 
                 4.6 
               
               
                   
                 2 
                 4.5 
               
               
                   
                 2 
                 4.3 
               
               
                   
                 2 
                 4.5 
               
               
                   
                 2 
                 4.5 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 2 
               
               
                   
                   
               
               
                   
                 Subject 
                 1 
                 2 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 Average 
                 4.73 
                 4.61 
               
               
                   
                 Standard Deviation 
                 0.51 
                 0.32 
               
               
                   
                 % Difference 
                 10.77 
                 6.90