Patent Publication Number: US-2002009730-A1

Title: Human stress array

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS  
     [0001] This application is a continuation-in-part of application Ser. No. 09/441,920 filed Nov. 17, 1999; application Ser. No. 09/440,305 filed Nov. 17, 1999; and application Ser. No. 09/222,256 filed Dec. 28, 1998; which applications are all continuation-in-part applications of application Ser. No. 09/053,375 filed on Mar. 31, 1998, the disclosure of which is herein incorporated by reference. 
    
    
     
       INTRODUCTION  
       [0002] 1. Technical Field  
       [0003] The field of this invention is biopolymeric arrays.  
       [0004] 2. Background of the Invention  
       [0005] “Biochips” or arrays of binding agents, such as oligonucleotides and peptides, have become an increasingly important tool in the biotechnology industry and related fields. These binding agent arrays, in which a plurality of binding agents are deposited onto a solid support surface in the form of an array or pattern, find use in a variety of applications, including drug screening, nucleic acid sequencing, mutation analysis, and the like. One important use of biochips is in the analysis of differential gene expression, where the expression of genes in different cells, normally a cell of interest and a control, is compared and any discrepancies in expression are identified. In such assays, the presence of discrepancies indicates a difference in the classes of genes expressed in the cells being compared.  
       [0006] In methods of differential gene expression, arrays find use by serving as a substrate to which is bound nucleic acid “probe” fragments. One then obtains “targets” from analogous cells, tissues or organs of a healthy and diseased organism. The targets are then hybridized to the immobilized set of nucleic acid “probe” fragments. Differences between the resultant hybridization patterns are then detected and related to differences in gene expression in the two sources.  
       [0007] A variety of different array technologies have been developed in order to meet the growing need of the biotechnology industry, as evidenced by the extensive number of patents and references listed in the relevant literature section below.  
       [0008] Despite the wide variety of array technologies currently in preparation or available on the market, there is a continued need to identify new array devices to meet the needs of specific research applications.  
       [0009] Relevant Literature  
       [0010] Patents and patent applications describing arrays of biopolymeric compounds and methods for their fabrication include: 5,242,974; 5,384,261; 5,405,783; 5,412,087; 5,424,186; 5,429,807; 5,436,327; 5,445,934; 5,472,672; 5,527,681; 5,529,756; 5,545,531; 5,554,501; 5,556,752; 5,561,071; 5,599,895; 5,624,711; 5,639,603; 5,658,734; 5,700,637; 5,744,305; 5,770,456; WO 93/17126; WO 95/11995; WO 95/35505; EP 742 287; and EP 799 897.  
       [0011] Patents and patent application describing methods of using arrays in various applications include: 5,143,854; 5,288,644; 5,324,633; 5,432,049; 5,470,710; 5,492,806; 5,503,980; 5,510,270; 5,525,464; 5,547,839; 5,580,732; 5,661,028; WO 95/21265; WO 96/31622; WO 97/10365; WO 97/27317; EP 373 203; and EP 785 280.  
       [0012] Other references of interest include: Atlas Human cDNA Expression Array I (Apr. 1997) CLONTECHniques XII: 4-7; Lockhart et al., Nature Biotechnology (1996) 14: 1675-1680; Shena et al., Science (1995) 270: 467-470; Schena et al., Proc. Nat&#39;l Acad. Sci. USA (1996)93:10614-10619; Shalon et al., Genome Res. (1996) 6: 639-645; Milosavljevic et al., Genome Res. (1996) 6:132-141; Nguyen et al., Genomics (1995)29: 207-216; Piétu et al., Genome Res. (1996) 6: 492-503; Zhao et al., Gene (1995) 166:207-213; Chalifour et al., Anal. Biochem. (1994) 216:299-304; Heller et al., Proc. Nat=l Acad. Sci. USA (1997) 94: 2150-2155; and Schena, M., BioAssays (1996) 18: 427-431.  
       SUMMARY OF THE INVENTION  
       [0013] Human stress arrays and kits including the same, as well as methods for their preparation and use in hybridization assays, are provided. The subject arrays have a plurality of probe polynucleotide spots each made up of a unique polynucleotide(s) that corresponds to a human gene associated with a stress response. The subject arrays find use in the expression analysis of human stress genes.  
       DEFINITIONS  
       [0014] The term “nucleic acid” as used herein means a polymer composed of nucleotides, e.g. deoxyribonucleotides or ribonucleotides.  
       [0015] The terms “ribonucleic acid” and “RNA” as used herein means a polymer composed of ribonucleotides.  
       [0016] The terms “deoxyribonucleic acid” and “DNA” as used herein means a polymer composed of deoxyribonucleotides.  
       [0017] The term “oligonucleotide” as used herein denotes single stranded nucleotide multimers of from about 10 to 100 nucleotides in length.  
       [0018] The term “polynucleotide” as used herein refers to single or double stranded polymer composed of nucleotide monomers of greater than about 120 nucleotides in length up to about 1000 nucleotides in length.  
       [0019] “Human stress genes” and “human stress related genes” are those genes that have been identified by those of skill in the art as genes whose products modulate cellular responses to various stressors, including heat shock, irradiation, infection, and treatment with cytotoxic or genotoxic compounds. Preferably, the human stress genes are genes that are well characterized, i.e. at least genes in which at least the partial sequence is known and the function of the expression product of the gene is at least partially understood. Specific human stress genes of interest include those listed in Table 1, infra. A gene is considered to be the same as a gene listed in Table 1 even if it: (a) has a different name or accession number in a gene sequence database, e.g. GENBANK; (b) has at least 90% homology (as determined using the FASTA program with default settings) to the sequence of one of the GENBANK accession numbers listed in Table 1; or (c) belongs to the same gene cluster as defined in NCBI in Unigene database available on the World Wide Web.  
       [0020] The “unique” polynucleotide sequences of each probe spot on the arrays of the subject invention are distinctive or different with respect to every other unique polynucleotide sequence on the arrays that corresponds to a human stress gene, as that term is defined herein. In other words, for at least 80% of the genes on the array, and more usually at least 90% of the genes on the array, any two different unique polynucleotides corresponding to a human stress gene on the array, (i.e. any two unique polynucleotides taken from different, non-identical spots on the array), are not homologous. By not homologous is meant that the sequence identity between the two given unique polynucleotides is less than about 90%, usually less than about 85% and more usually less than about 80% as measured by the FASTA program using default settings. Moreover, each polynucleotide sequence on the array is statistically chosen to ensure that the probability of homology to any sequence of that type is very low. Morever, each unique sequence on the array is statistically chosen to insure that probability of homology to any other known sequence associated with human stress genes is very low, whether or not the other sequence is represented on the array. An important feature of the individual polynucleotide probe compositions of the subject arrays is that they are only a fragment of the entire cDNA of the human stress gene to which they correspond. In other words, for each gene represented on the array, the entire cDNA sequence of the gene is not represented on the array. Instead, the sequence of only a portion or fragment of the entire cDNA is represented on the array by this unique polynucleotide.  
       [0021] The term “polynucleotide probe composition” refers to the nucleic acid composition that makes up each of the probe spots on the array that correspond to a particular human stress gene. Thus, the term ‘polynucleotide probe composition’ includes nucleic acid compositions of unique polynucleotides but excludes control or calibrating polynucleotides (e.g. polynucleotides corresponding to housekeeping genes) which may also be present on the array, as described in greater detail infra. The polynucleotide compositions are made up of single stranded polynucleotides (i.e. polynucleotides that are not hybridized to each other), where all of the polynucleotides in the probe composition may be identical to each other or there may be two or more different polynucleotides (i.e. polynucleotides of different nucleotide sequence) in each probe composition, e.g. where the two different polynucleotides are complementary to each other.  
       DESCRIPTION OF THE SPECIFIC EMBODIMENTS  
       [0022] Human stress arrays, as well as methods for their preparation and use, are provided. In the subject human stress arrays, a plurality of polynucleotide probe spots is stably associated with the surface of a solid support. Each different polynucleotide probe spot is made up of a unique polynucleotide that corresponds to a human stress gene of interest. The subject arrays find particular use in gene expression assays of human stress genes. In further describing the subject invention, the human stress arrays themselves are first discussed, followed by a description of methods for their preparation. Next, a review of representative applications in which the subject arrays may be employed is provided.  
       [0023] It is to be understood that the invention is not limited to the particular embodiments of the invention described below, as variations of the particular embodiments may be made and still fall within the scope of the appended claims. It is also to be understood that the terminology employed is for the purpose of describing particular embodiments, and is not intended to be limiting. Instead, the scope of the present invention will be established by the appended claims.  
       [0024] In this specification and the appended claims, the singular forms “a,” “an,” and “the” include plural reference unless the context clearly dictates otherwise. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood to one of ordinary skill in the art to which this invention belongs.  
       [0025] Arrays of the Subject Invention-General Description  
       [0026] Array Structure  
       [0027] The arrays of the subject invention have a plurality of polynucleotide probe spots stably (i.e. immobilized such that the probe maintains its position relative to the surface of the array under washing conditions, as described infra) associated with a surface of a solid support. Each probe spot on the array comprises a polynucleotide probe sample or polynucleotide probe composition of known identity, usually of known sequence, as described in greater detail below. The polynucleotide probe spots on the array may be any convenient shape, but will typically be circular, elliptoid, oval, annular, or some other analogously curved shape, where the shape may, in certain embodiments, be a result of the particular method employed to produce the array. The density of the all of the spots on the solid surface, i.e. both probe spots and non-probe spots, e.g. calibration spots, control spots, etc., is at least about 5/cm 2  and usually at least about 10/cm 2  but does not exceed about 1000/cm 2 , and in many embodiments does not exceed about 500/cm 2 , where in certain preferred embodiments, the density does not exceed about 400/cm 2 , usually does not exceed about 300/cm 2 , and more usually does not exceed about 60/cm 2 . The spots may be arranged in any convenient pattern across or over the surface of the array, such as in rows and columns so as to form a grid, in a circular pattern, and the like, where generally the pattern of spots will be present in the form of a grid across the surface of the solid support.  
       [0028] In the subject arrays, the spots of the pattern are stably associated with the surface of a solid support, where the support may be a flexible or rigid solid support. By stably associated is meant that the polynucleotides of the spots maintain their position relative to the solid support under hybridization and washing conditions. As such, the polynucleotide members which make up the spots can be non-covalently or covalently stably associated with the support surface. Examples of non-covalent association include non-specific adsorption, binding based on electrostatic (e.g. ion, ion pair interactions), hydrophobic interactions, hydrogen bonding interactions, specific binding through a specific binding pair member covalently attached to the support surface, and the like. Examples of covalent binding include covalent bonds formed between the spot polynucleotides and a functional group present on the surface of the rigid support, e.g. —OH, where the functional group may be naturally occurring or present as a member of an introduced linking group, as described in greater detail below.  
       [0029] The array is present on either a flexible or rigid substrate. By flexible is meant that the support is capable of being bent, folded or similarly manipulated without breakage. Examples of solid materials which are flexible solid supports with respect to the present invention include membranes, flexible plastic films, and the like. By rigid is meant that the support is solid and does not readily bend, i.e. the support is not flexible. As such, the rigid substrates of the subject arrays are sufficient to provide physical support and structure to the polymeric targets present thereon under the assay conditions in which the array is employed, particularly under high throughput handling conditions. Furthermore, when the rigid supports of the subject invention are bent, they are prone to breakage.  
       [0030] The solid supports upon which the subject patterns of spots are present in the subject arrays may take a variety of configurations ranging from simple to complex, depending on the intended use of the array. Thus, the substrate could have an overall slide or plate configuration, such as a rectangular or disc configuration. In many embodiments, the substrate will have a rectangular cross-sectional shape, having a length of from about 10 mm to 200 mm, usually from about 40 to 150 mm and more usually from about 75 to 125 mm and a width of from about 10 mm to 200 mm, usually from about 20 mm to 120 mm and more usually from about 25 to 80 mm, and a thickness of from about 0.01 mm to 5.0 mm, usually from about 0.1 mm to 2 mm and more usually from about 0.2 to 1 mm.  
       [0031] The substrates of the subject arrays may be fabricated from a variety of materials. The materials from which the substrate is fabricated should ideally exhibit a low level of non-specific binding during hybridization events. In many situations, it will also be preferable to employ a material that is transparent to visible and/or UV light. For flexible substrates, materials of interest include: nylon, both modified and unmodified, nitrocellulose, polypropylene, and the like, where a nylon membrane, as well as derivatives thereof, is of particular interest in this embodiment. For rigid substrates, specific materials of interest include: glass; plastics, e.g. polytetrafluoroethylene, polypropylene, polystyrene, polycarbonate, and blends thereof, and the like; metals, e.g. gold, platinum, and the like; etc.  
       [0032] The substrates of the subject arrays comprise at least one surface on which the pattern of probe spots is present, where the surface may be smooth or substantially planar, or have irregularities, such as depressions or elevations. The surface on which the pattern of spots is present may be modified with one or more different layers of compounds that serve to modify the properties of the surface in a desirable manner. Such modification layers, when present, will generally range in thickness from a monomolecular thickness to about 1 mm, usually from a monomolecular thickness to about 0.1 mm and more usually from a monomolecular thickness to about 0.001 mm. Modification layers of interest include: inorganic and organic layers such as metals, metal oxides, polymers, small organic molecules and the like. Polymeric layers of interest include layers of: peptides, proteins, polynucleic acids or mimetics thereof, e.g. peptide nucleic acids and the like; polysaccharides, phospholipids, polyurethanes, polyesters, polycarbonates, polyureas, polyamides, polyethyleneamines, polyarylene sulfides, polysiloxanes, polyimides, polyacetates, and the like, where the polymers may be hetero- or homopolymeric, and may or may not have separate functional moieties attached thereto, e.g. conjugated.  
       [0033] The total number of probe spots on the substrate will vary depending on the number of different polynucleotide probes one wishes to display on the surface, as may be desired depending on the particular application in which the subject arrays are to be employed. Generally, the pattern present on the surface of the array will comprise at least about 10 distinct spots, usually at least about 20 distinct spots, and more usually at least about 50 distinct spots, where the number of spots may be as high as 10,000 or higher, but will usually not exceed about 5,000 distinct spots, and more usually will not exceed about 3,000 distinct spots. In many embodiments, it is preferable to have each distinct probe composition presented in duplicate, i.e. so that there are two spots for each distinct polynucleotide probe composition of the array. In certain embodiments, the number of spots will range from about 100 to 600, usually 200 to 500.  
       [0034] In the arrays of the subject invention (particularly those designed for use in high throughput applications, such as high throughput analysis applications), a single pattern of spots may be present on the array or the array may comprise a plurality of different spot patterns, each pattern being as defined above. When a plurality of different spot patterns are present, the patterns may be identical to each other, such that the array comprises two or more identical spot patterns on its surface, or the spot patterns may be different, e.g. in arrays that have two or more different types of target nucleic acids represented on their surface, e.g an array that has a pattern of spots corresponding to human stress genes and a pattern of spots corresponding to key human genes. Where a plurality of spot patterns are present on the array, the number of different spot patterns is at least 2, usually at least 6, more usually at least 24 or 96, where the number of different patterns will generally not exceed about 384.  
       [0035] Where the array comprises a plurality of spot patterns on its surface, preferably the array comprises a plurality of reaction chambers, wherein each chamber has a bottom surface having associated therewith an pattern of spots and at least one wall, usually a plurality of walls surrounding the bottom surface. Such array configurations and the preparation thereof is further described in U.S. patent application Ser. No. 08/974,298 filed on Nov. 19, 1997, the disclosure of which is herein incorporated by reference. Of particular interest in many embodiments are arrays in which the same pattern of spots in reproduced in 24 or 96 different reaction chambers across the surface of the array.  
       [0036] Within any given pattern of spots on the array, there may be a single spot that corresponds to a given target or a number of different spots that correspond to the same target, where when a plurality of different spots are present that correspond to the same target, the probe compositions of each spot that corresponds to the same target may be identical of different. In other words, a plurality of different targets are represented in the pattern of spots, where each target may correspond to a single spot or a plurality of spots, where the probe composition among the plurality of spots corresponding to the same target may be the same or different. Where a plurality of spots (of the same or different composition) corresponding to the same target is present on the array, the number of spots in this plurality will be at least about 2 and may be as high as 10, but will usually not exceed about 5. The number of different targets represented on the array is at least about 2, usually at least about 10 and more usually at least about 20, where in many embodiments the number of different targets, e.g. genes, represented on the array is at least about 50. The number of different targets represented on the array may be as high as 1000 or higher, but will usually not exceed about 800 and more usually will not exceed about 700. In many preferred embodiments, the number of different targets represented on the array ranges from about 100 to 400, usually from about 200 to 300. A target is considered to be represented on an array if it is able to hybridize to one or more probe compositions on the array.  
       [0037] The amount of polynucleotide present in each spot will be sufficient to provide for adequate hybridization and detection of target nucleic acid during the assay in which the array is employed. Generally, the amount of polynucleotide in each spot will be at least about 0.1 ng, usually at least about 0.5 ng and more usually at least about 1 ng, where the amount may be as high as 1000 ng or higher, but will usually not exceed about 20 ng and more usually will not exceed about 10 ng. The copy number of each polynucleotide in a spot will be sufficient to provide enough hybridization sites for target molecule to yield a detectable signal, and will generally range from about 0.01 fmol to 50 fmol, usually from about 0.05 fmol to 20 fmol and more usually from about 0.1 fmol to 5 fmol. Where the spot has an overall circular dimension, the diameter of the spot will generally range from about 10 to 5,000 μm, usually from about 20 to 2,000 μm and more usually from about 50 to 1000 μm.  
       [0038] A critical feature of the subject arrays is that all of the probe polynucleotide spots of the array correspond to human stress genes of interest, particularly genes that have been identified by those of skill in the art as genes whose products modulate cellular responses to various stressors, including heat shock, irradiation, infection, and treatment with cytotoxic or genotoxic compounds. As such, each polynucleotide probe spot on the array will correspond to a human stress gene of interest. Each probe spot on the array may correspond to a different human stress gene. Alternatively, two or more, usually no more than four, and more usually no more than three, different probe spots may correspond to the same human stress gene, i.e. a human stress gene may be represented by one or a plurality of different probe spots on the array. Furthermore, any given human stress gene may be represented by two or more identical probe spots on the array, e.g. a particular probe spot may be presented on the array once or in duplicate, triplicate, etc, as mentioned above. The number of different human stress genes represented on the array may vary, where in certain embodiments the number of different human stress genes represented on the array will range from about 50 to 1000, usually from about 100 to 700 and more usually from about 100 to 400; while in other embodiments the number will range from about 50 to 2000, usually from about 100 to 1500. A human stress gene is considered to be represented on a given array if a target nucleic acid derived from the human stress gene is able to hybridize to at least one probe spot on the array. Human stress genes that may be represented on the arrays include: genes that express products which are known to modulate the cellular response to stress factors, such as stressors, heat shock, irradiation, infection, and treatment with cytotoxic or genotoxic compounds, and the like. Specific human stress genes that may be represented on the arrays of the subject invention include those listed in Table 1, Table 2 and/or Table 3, infra. In many preferred embodiments, the subject human stress arrays will include at least 20, usually at least 50 and more usually at least 100 of the genes listed in one or more of these tables (i.e. at least 20, usually at least 50 and more usually at least 100 of the genes listed in Table 1 are represented on the array), where in certain preferred embodiments, all of the genes listed in Tables 1, 2 or 3 are present on the array. In one embodiment, the array is made up of polynucleotide probes having a sequence that is identical to and/or complementary to, or at least partially includes, each of the specific gene regions listed in Col. 3 of Table 1.  
       [0039] The average length of the probe polynucleotides on the array is chosen to be of sufficient length to provide a strong and reproducible signal, as well as tight and robust hybridization. In certain embodiments, the average length of the polynucleotides of the array will typically range from about 120 to 1000 nt and usually from about 150 to 800 nt, where in many embodiments, the average length ranges from about 200 to 700 nt, and usually 200 to 600 nt. In yet other embodiments, the length of the probes ranges from 50 to 120 nt, as disclosed in U.S. patent application Ser. No. 09/440,829, the disclosure of which is herein incorporated by reference. The length of each polynucleotide on the array is less than the length of the mRNA to which it corresponds. As such, the polynucleotide represents only a fraction of the full length cDNA to which it corresponds.  
       [0040] The polynucleotide probe compositions that make up each spot on the array will be substantially, usually completely, free of non-nucleic acids, i.e. the probe compositions will not comprise non-nucleic acid biomolecules found in cells, such as proteins, lipids, and polysaccharides. In other words, the oligonucleotide spots of the arrays are substantially, if not entirely, free of non-nucleic acid cellular constituents. By substantially free is meant that the probe composition is at least about 90%, usually at least about 95% and more usually at least about 98% dry weight nucleic acid.  
       [0041] The polynucleotide probes may be nucleic acid, e.g. RNA, DNA, or nucleic acid mimetics, e.g. such as nucleic acids comprising non-naturally occurring heterocyclic nitrogenous bases, peptide-nucleic acids, locked nucleic acids (see Singh &amp; Wengel, Chem. Commun. (1998) 1247-1248); and the like. Nucleic acid mimetics that may be polynucleotide probes on the present arrays include nucleic acids chemically modified from the native phosphodiester structure in order to increase their intracellular stability and binding affinity. A number of such modifications have been described in the literature which alter the chemistry of the backbone, sugars or heterocyclic bases. Among useful changes in the backbone chemistry are phosphorothioates; phosphorodithioates, where both of the non-bridging oxygens are substituted with sulfur; phosphoroamidites; alkyl phosphotriesters and boranophosphates. Achiral phosphate derivatives include 3′-O′-5′-S-phosphorothioate, 3′-S-5′-O-phosphorothioate, 3′-CH 2 -5′-O-phosphonate and 3′-NH-5′-O-phosphoroamidate. Peptide nucleic acids replace the entire ribose phosphodiester backbone with a peptide linkage. Sugar modifications are also used to enhance stability and affinity. The α-anomer of deoxyribose may be used, where the base is inverted with respect to the natural β-anomer. The 2′-OH of the ribose sugar may be altered to form 2′-O-methyl or 2′-O-allyl sugars, which provides resistance to degradation without comprising affinity. Modification of the heterocyclic bases must maintain proper base pairing. Some useful substitutions include deoxyuridine for deoxythymidine; 5-methyl-2′-deoxycytidine and 5-bromo-2′-deoxycytidine for deoxycytidine. 5-propynyl-2′-deoxyuridine and 5-propynyl-2′-deoxycytidine have been shown to increase affinity and biological activity when substituted for deoxythymidine and deoxycytidine, respectively.  
       [0042] As mentioned above, the subject arrays typically comprise one or more additional spots of polynucleotides which are not human stress genes. Other spots which may be present on the substrate surface include spots comprising genomic DNA, housekeeping genes, negative and positive control genes, and the like. These latter types of spots comprise polynucleotides that are not “unique” as that term is defined and used herein, i.e. they are “common.” In other words, they are calibrating or control genes whose function is not to tell whether a particular “key” human stress gene of interest is expressed, i.e. whether a particular human stress gene is expressed in a particular sample, but rather to provide other useful information, such as background or basal level of expression, and the like. For example, spots comprising genomic DNA may be provided in the array, where such spots may serve as orientation marks. Spots comprising plasmid and bacteriophage genes, genes from the same or another species which are not expressed and do not cross hybridize with the cDNA target, and the like, may be present and serve as negative controls. Specific negative controls of interest include: M13 mp18(+) strand DNA, lambda DNA and pUC18. In addition, spots comprising housekeeping genes and other control genes from the same or another species may be present, which spots serve in the normalization of mRNA abundance and standardization of hybridization signal intensity in the sample assayed with the array. Specific housekeeping genes of interest include: ubiquitin, phospholipase A2, hypoxanthine-guanine phosphoribosyl transferase, glyceraldehyde 3-phosphate dehydrogenase, tubulina alpha, HLA class I histocompatibility antigen, C-4 alpha chain, beta-actin, 23 kDa highly basic protein and ribosomal protein S9.  
       [0043] Polynucleotide Probes of the Arrays  
       [0044] Each probe spot of the pattern present on the surface of the substrate is made up of a unique polynucleotide probe composition. By “polynucleotide probe composition” is meant a collection or population of single stranded polynucleotides capable of participating in a hybridization event under appropriate hybridization conditions, where each of the individual polynucleotides may be the same—have the same nucleotide sequence—or have different sequences, for example the probe composition may consist of 2 different single stranded polynucleotides that are complementary to each other (i.e. the two different polynucleotides in the spot are complementary but physically separated so as to be single stranded, i.e. not hybridized to each other). In many embodiments, the probe compositions will comprise two complementary, single stranded polynucleotides. In the polynucleotide probe compositions, the sequence of the polynucleotides are chosen so that each distinct unique polynucleotide does not cross-hybridize with any other distinct unique polynucleotide of another probe spot on the array, i.e. the polynucleotide of any other polynucleotide composition that corresponds to a human stress gene. As such, the nucleotide sequence of each unique polynucleotide of a probe composition will have less than 90% homology, usually less than 85% homology, and more usually less than 80% homology with any other different polynucleotide of a probe composition of the array, where homology is determined by sequence analysis comparison using the FASTA program using default settings. The sequence of unique polynucleotides in the probe compositions are not conserved sequences found in a number of different genes (at least two), where a conserved sequence is defined as a stretch of from about 40 to 200 nucleotides which have at least about 90% sequence identity, where sequence identity is measured as above. The polynucleotide will generally be a deoxyribonucleic acid having a length of from about 120 to 1000, usually from 120 to 700 nt, and more usually 200 to 600 nt in certain embodiments; while in other embodiments the length will range from 50 to 120 nt, as described above. The polynucleotide will not cross-hybridize with any other polynucleotide on the array under standard hybridization conditions and usually stringent hybridization conditions. An example of stringent hybridization conditions is hybridization at 50° C. or higher and 0.1×SSC (15 mM sodium chloride/1.5 mM sodium citrate). Another example of stringent hybridization conditions is overnight incubation at 42° C. in a solution: 50% formamide, 5×SSC (150 mM NaCl, 15 mM trisodium citrate), 50 mM sodium phosphate (pH7.6), 5×Denhardt&#39;s solution, 10% dextran sulfate, and 20 μg/ml denatured, sheared salmon sperm DNA, followed by washing the filters in 0.1×SSC at about 65° C. Stringent hybridization conditions are hybridization conditions that are at least as stringent as the above representative conditions. Other stringent hybridization conditions are known in the art and may also be employed to identify nucleic acids of this particular embodiment of the invention. Again, the length of the polynucleotide will be shorter than the mRNA to which it corresponds.  
       [0045] Array Preparation  
       [0046] The subject arrays can be prepared using any convenient means. One means of preparing the subject arrays is to first synthesize the polynucleotides for each spot and then deposit the polynucleotides as a spot on the support surface. The polynucleotides may be prepared using any convenient methodology, such as automated solid phase synthesis protocols, restriction digestion of a gene fragment insert cloned into a vector, preparative PCR and like, where preparative PCR or enzymatic synthesis is preferred in view of the length and the large number of polynucleotides that must be generated for each array. In the case of automated solid phase synthesis, each polynucleotide can be represented by several overlapping or non-overlapping oligonucleotides from 10 to 100 nucleotides in length, which cover all or a partial sequence of a gene or polynucleotide. See U.S. patent application Ser. No. 60/104,179, the disclosure of which is herein incorporated by reference.  
       [0047] For preparative PCR, primers flanking either side of the portion of the gene of interest will be employed to produce amplified copy numbers of the portion of interest. Methods of performing preparative PCR are well known in the art, as summarized in PCR, Essential Techniques (Ed. J. F. Burke, John Wiley &amp; Sons)(1996). Alternatively, if a gene fragment of interest is cloned into a vector, vector primers can be used to amplify the gene fragment of interest to produce the polynucleotide.  
       [0048] In determining the portion of the gene to be amplified and subsequently placed on the array, regions of the gene having a sequence unique to that gene should preferably be amplified. Different methods may be employed to choose the specific region of the gene to be amplified. Thus, one can use a random approach based on availability of a gene of interest. However, instead of using a random approach which is based on availability of a gene of interest, a rational design approach may also be employed to choose the optimal sequence for the hybridization array. Preferably, the region of the gene that is selected and amplified is chosen based on the following criteria. First, the sequence that is chosen should yield a polynucleotide that does not cross-hybridize with any other polynucleotide that is present on the array. Second, the sequence should be chosen such that the polynucleotide has a low probability of cross-hybridizing with a polynucleotide having a nucleotide sequence found in any other gene, whether or not the gene is to be represented on the array. As such, sequences that are avoided include those found in: highly expressed gene products, structural RNAs, repeated sequences found in the sample to be tested with the array and sequences found in vectors. A further consideration is to select sequences which provide for minimal or no secondary structure, structure which allows for optimal hybridization but low non-specific binding, equal or similar thermal stabilities, and optimal hybridization characteristics.  
       [0049] The prepared polynucleotides may be spotted on the support using any convenient methodology, including manual techniques, e.g. by micro pipette, ink jet, pins, etc., and automated protocols. See U.S. Pat. No. 5,770,151 and WO 95/35505, the disclosures of which are herein incorporated by reference, for discussions of representative ways of spotting polynucleotides on a support. Of particular interest is the use of an automated spotting device, such as the Beckman Biomek 2000 (Beckman Instruments). As mentioned above, the polynucleotide probe compositions that are spotted onto the array surface are made up of single stranded polynucleotides, where all the polynucleotides may be identical to each other or a population of complementary polynucleotides may be present in each spot.  
       [0050] Methods of Using the Subject Arrays  
       [0051] The subject arrays find use in a variety of different applications in which one is interested in detecting the occurrence of one or more binding events between target nucleic acids and probes on the array and then relating the occurrence of the binding event(s) to the presence of a target(s) in a sample, i.e. the expression of a particular human stress gene in a sample. In general, the device will be contacted with the sample suspected of containing the target human stress gene under conditions sufficient for binding of any target present in the sample to a complementary polynucleotide present on the array. Generally, the sample will be a fluid sample and contact will be achieved by introduction of an appropriate volume of the fluid sample onto the array surface, where introduction can via inlet port, deposition, dipping the array into a fluid sample, and the like.  
       [0052] Generation of Labeled Target  
       [0053] Targets may be generated by methods known in the art, mRNA can be labeled and used directly as a target, or converted to a labeled cDNA target. Generally, such methods include the use of oligonucleotide primers. Primers that may be employed include oligo dT, random primers, e.g. random hexamers and gene specific primers, as described in U.S. patent application Ser. No. 08/859,998, the disclosure of which is herein incorporated by reference. Where gene specific primers are employed, the gene specific primers are preferably those primers that correspond to the different polynucleotide spots on the array. Thus, one will preferably employ gene specific primers for each different polynucleotide that is present on the array, so that if the gene is expressed in the particular cell or tissue being analyzed, labeled target will be generated from the sample for that gene. In this manner, if a particular human stress gene present on the array is expressed in a particular sample, the appropriate target will be generated and subsequently identified.  
       [0054] A variety of different protocols may be used to generate the labeled target nucleic acids, as is known in the art, where such methods typically rely on the enzymatic generation of the labeled target using the initial primer. Labeled primers can be employed to generate the labeled target. Alternatively, label can be incorporated during first strand synthesis or subsequent synthesis, labeling or amplification steps in order to produce labeled target. Representative methods of producing labeled target are disclosed in U.S. patent application Ser. No. 08/859,998, the disclosure of which is herein incorporated by reference. Alternatively, the label can be introduced by chemical cDNA synthesis.  
       [0055] Hybridization and Detection  
       [0056] As mentioned above, following preparation of the target nucleic acid from the tissue or cell of interest, the labeled target nucleic acid is then contacted with the array under hybridization conditions, where such conditions can be adjusted, as desired, to provide for an optimum level of specificity in view of the particular assay being performed. Suitable hybridization conditions are well known to those of skill in the art and reviewed in Maniatis et al, supra and WO 95/21944, e.g. stringent conditions (e.g. at 50° C. or higher and 0.1×SSC (15 mM sodium chloride/01.5 mM sodium citrate). In analyzing the differences in the population of labeled target nucleic acids generated from two or more physiological sources using the arrays described above, each population of labeled target nucleic acids are separately contacted to identical probe arrays or together to the same array under conditions of hybridization, preferably under stringent hybridization conditions, such that labeled target nucleic acids hybridize to complementary probes on the substrate surface.  
       [0057] Where all of the target sequences comprise the same label, different arrays will be employed for each physiological source (where different could include using the same array at different times). Alternatively, where the labels of the targets are different and distinguishable for each of the different physiological sources being assayed, the opportunity arises to use the same array at the same time for each of the different target populations. Examples of distinguishable labels are well known in the art and include: two or more different emission wavelength fluorescent dyes, like Cy3 and Cy5, two or more isotopes with different energy of emission, like  32 P and  33 P, light scattering particles with different scattering spectra, labels which generate signals under different treatment conditions, like temperature, pH, treatment by additional chemical agents, etc., or generate signals at different time points after treatment. Using one or more enzymes for signal generation allows for the use of an even greater variety of distinguishable labels, based on different substrate specificity of enzymes (alkaline phosphatase/peroxidase).  
       [0058] Following hybridization, non-hybridized labeled nucleic acid is removed from the support surface conveniently by washing, generating a pattern of hybridized nucleic acid on the substrate surface. A variety of wash solutions are known to those of skill in the art and may be used.  
       [0059] The resultant hybridization patterns of labeled nucleic acids may be visualized or detected in a variety of ways, with the particular manner of detection being chosen based on the particular label of the target nucleic acid, where representative detection means include scintillation counting, autoradiography, fluorescence measurement, colorimetric measurement, light emission measurement, light scattering and the like.  
       [0060] Following detection or visualization, the hybridization patterns may be compared to identify differences between the patterns. Where arrays in which each of the different probes corresponds to a known gene are employed, any discrepancies can be related to a differential expression of a particular gene in the physiological sources being compared.  
       [0061] Utility  
       [0062] The subject methods find use in, among other applications, in differential human stress gene expression assays. Thus, one may use the subject methods in the differential expression analysis of human stress genes in: (a) diseased and normal tissue, e.g. neoplastic and normal tissue, (b) different tissue or tissue types; (c) developmental stage; (d) response to external or internal stimulus; (e) response to treatment; and the like. The subject arrays therefore find use in broad scale expression screening for research into the role of human stress genes in normal and diseased conditions, as well as in high throughput drug screening and drug discovery and research, such as the effect of a particular active agent on the expression pattern of genes in a particular cell, where such information can be used to reveal drug toxicity, carcinogenicity, etc., environmental monitoring, disease research and the like.  
       [0063] Kits  
       [0064] Also provided are kits for performing analyte binding assays using the subject devices, where kits for carrying out differential gene expression analysis assays are preferred. Such kits according to the subject invention will at least comprise a human stress array according to the subject invention. The kits may further comprise one or more additional reagents employed in the various methods, such as primers for generating target nucleic acids, dNTPs and/or rNTPs, which may be either premixed or separate, one or more uniquely labeled dNTPs and/or rNTPs, such as biotinylated or Cy3 or Cy5 tagged dNTPs, or other post synthesis labeling reagent, such as chemically active derivatives of fluorescent dyes, biotin, digoxigenin, or strept/avidin-label conjugate or antibody-label conjugate, enzymes, such as reverse transcriptases, DNA polymerases, and the like, various buffer mediums, e.g. hybridization and washing buffers, labeled target purification reagents and components, like spin columns, etc., signal generation and detection reagents, e.g. streptavidin-alkaline phosphatase conjugate, chemifluorescent or chemiluminescent substrate, and the like.  
       [0065] The following examples are offered by way of illustration and not by way of limitation.  
       EXPERIMENTAL 
     
    
    
     EXAMPLE 1  
     Generation of Human Stress cDNA Array  
     [0066] 236 cDNA fragments corresponding to 236 different human stress genes as listed in Table 1 were amplified from quick-clone cDNA (CLONTECH) in 236 separate test tubes using a combination of sense and antisense gene-specific primers capable of amplifying the specific gene fragments of interest as specified in Table 1. Amplification was conducted in a 100-μl volume containing 2 μl of mixture of 10 Quick-clone cDNA from placenta, brain, liver, lung, leukocytes, spleen, skeletal muscle, testis, kidney and ovary (CLONTECH), 40 mM Tricine-KOH (pH 9.2 at 22° C.), 3.5 mM Mg(OAc) 2 , 10 mM KOAc, 75 μg/ml BSA, 200 μM of each dATP, dGTP, dCTP and dTTP, 0.2 μM of each sense and antisense gene-specific primers and 2 μl of KlenTaq Polymerase mix. Temperature parameters of the PCR reactions were as follows: 1 min at 95° C. followed by 20-35 cycles of 95° C. for 15 sec and 68° C. for 2 min; followed by a 10-min final extension at 68° C. PCR products were examined on 1.2% agarose/EtBr gels in 1×TBE buffer. As a DNA size marker a 1 Kb DNA Ladder was used. ds cDNA was then precipitated by addition of a half volume of 4M ammonium acetate (about 35 μl) and 3.7 volumes of 95% ethanol (about 260 μl). After vortexing, the tube was immediately centrifuged at 14,000 r.p.m. in a microcentrifuge for 20 min. The pellet was washed with 80% ethanol without vortexing, centrifuged as above for 10 min, air dried, and dissolved in 10 μl of deionized water. Yield of ds cDNA after the amplification step was about 5 μg. The ds cDNA fragments for all 236 genes were cloned into pAtlas 1A-cloning vector (Clontech) using blunt end ligation by T4 DNA polymerase and identity of the clones was confirmed by sequence analysis. The ds cDNA inserts with the sequence corresponding 236 genes were amplified by PCR using a combination of antisense and sense gene-specific primers, as described above. The ds cDNA was denatured by adding 1 μl of 10×denaturing solution (1 M NaOH, 10 mM EDTA) and incubating at 65° C. for 20 min. All cDNA probes were transferred in 384-well plate and loaded on positively charged nylon membrane (Schleher &amp; Schull) using 384 pin tool and Biomek 2000 (Beckman) robot.  
     [0067] The resultant array has 236 different human stress genes represented on it. The specific human stress genes represented on the array are listed in Table 1. Also provided in Table 1 is the specific region of each gene that is represented on the array. See Col. 3 of Table 1. Thus, Table 1 also provides the sequence for each polynucleotide probe on the array. For example, the array comprises a polynucleotide probe to MDM2 protein, where the probe has a DNA sequence that is either complementary or identical to the sequence of the mRNA from the 920-1232 nucleotide of the sense strand counting from the 5′ end of the mRNA sequence, where the entire sequence has been deposited in GENBANK under accession nos. Z12020 and M92424 and is therefore readily available.  
                       TABLE 1                               FRAGMENT               LENGTH, bp       GENE NAME   GENBANK #   (start-end)                  MDM2 PROTEIN (p53-associated gene) +   Z12020; M92424    920-1232       MDM2-A + MDM2-C       p53 cellular tumor antigen   M14694; M14695   690-964       basic transcription factor 62 kDa subunit   M95809   1449-1831       basic transcription factor 44 kDa subunit   Z30094   606-843       DNA-binding protein PO-GA   L14922   3196-3413       TCF5 [HEAT SHOCK FACTOR PROTEIN   M64673   294-572       1] CCAAT enhancer-binding protein beta       [HG99]       recA-like protein HsRad51; DNA REPAIR   D13804    867-1159       PROTEIN RAD51 HOMOLOG       excision repair protein ERCC6   L0479 1   1772-2194       MAP kinase kinase; DUAL SPECIFICITY   L05624    842-1217       MITOGEN-ACTIVATED PROTEIN       KINASE KINASE 1 (EC 2.7.1.-); ERK       ACTIVATOR KINASE 1); MAPK/ERK       KINASE 1 (MEK1)       replication factor C 36-kDa subunit   L07540    708-1051       replication factor C 38-kDa subunit   L07541   438-762       ERCC5 excision repair protein; DNA-   L20046; X69978   1374-1638       REPAIR PROTEIN COMPLEMENTING       XP-G CELLS (XERODERMA       PIGMENTOSUM GROUP G       COMPLEMENTING PROTEIN)       Rad   L24564   489-780       Ku (p70/p80) subunit; ATP-DEPENDENT   M30938   2340-2764       DNA HELICASE II, 86-kDa SUBUNIT;       LUPUS KU AUTOANTIGEN PROTEIN       P86; THYROID-LUPUS AUTOANTIGEN       (TLAA); CTC BOX BINDING FACTOR 85-       kDa SUBUNIT (CTCBF) (CTC85);       NUCLEAR FACTOR IV (KU80) (XRCC5)       cyclic AMP response element-binding protein   M31630   316-636       (HB 16) 3′ end       DNA repair helicase (ERCC3); DNA-   M31899   2109-2466       REPAIR PROTEIN COMPLEMENTING       XP-B CELLS; XERODERMA       PIGMENTOSUM GROUP B       COMPLEMENTING PROTEIN; BASAL       TRANSCRIPTION FACTOR 2 89-kDa       SUBUNIT (BTF2-p89); TFIIH 89-kDa       SUBUNIT       Ku protein subunit; ATP-DEPENDENT DNA   M32865; S38729   1729-1974       HELICASE II 70-kDa SUBUNIT; LUPUS       KU AUTOANTIGEN PROTEIN P70;       THYROID-LUPUS AUTO-ANTIGEN       (TLAA); CTC BOX BINDING FACTOR 75-       kDa SUBUNIT (CTCBF) (CTC75) (XRCC6)       active transcription factor CREB   M34356   433-780       DNA-repair protein (XRCC1)   M36089   1226-1539       replication protein A 70-kDa subunit (RP-A)   M63488   1498-1838       (RE-A); SINGLE-STRANDED DNA-       BINDING PROTEIN       HHR6A (yeast RAD 6 homologue)   M74524   175-433       replication factor C 40-kDa subunit (A1)   M87338    882-1286       replication factor C 37-kDa subunit   M87339    98-355       melanoma differentiation associated protein 6   U09579; L25610   1745-2063       (mda-6); CYCLIN-DEPENDENT KINASE       INHIBITOR 1; CDK-INTERACTING       PROTEIN 1 (CIP1) (WAF1) (CDKN1A)       (CDKN1) (SDI1) (PIC1) (CAP20)       DNA polymerase alpha-subunit   X06745   3721-4093       single-stranded DNA-binding protein pur-   M96684   563-855       alpha       DNA topoisomerase I   J03250   2388-2796       DNA topoisomerase II alpha   J04088   2459-2883       6-O-methylguanine-DNA methyltransferase   M29971   241-546       (MGMT); METHYLATED-DNA--       PROTEIN-CYSTEINE       METHYLTRANSFERASE       DNA excision repair protein ERCC2 5′ end;   X52221; HT1175   1520-1821       DNA-REPMR PROTEIN       COMPLEMENTING XP-D CELLS;       XERODERMA PIGMENTOSUM GROUP D       COMPLEMENTING PROTEIN       glutathione reductase   HT1483    719-1057       glutathione 5-transferase 12   HT1790    72-420       DNA excision repair protein ERCC1   M13194; HT1848   625-938       glutathione 5-transferase M1   HT2041   504-906       glutathione 5-transferase pi   HT2042   203-511       glutathione S-transferase A1   HT2168   257-583       glutathione peroxidase   HT2859   454-745       superoxide dismutase 1 cytosolic   K00065; HT3218   198-496       DNA mismatch repair protein hmlh 1   U07418; HT3337   1765-2020       xeroderma pigmentosum group C repair   HT4209   582-885       complementing protein p58/HHR23B       xeroderma pigmentosum group C repair   D21235; HT4247   355-632       complementing protein HHR23A; UV       EXCISION REPAIR PROTEIN PROTEIN       RAD23       glutathione 5-transferase T1   HT4547   617-914       heat-shock protein 40   D49547   1400-1782       STRESS-ACTIVATED protein kinase   L26318    952-1263       (JNK1) (EC 2.7.1.-); C-JUN N-TERMINAL       KINASE 1 (JNK-46)       p38 mitogen activated protein (MAP) kinase;   L35253; L35263    925-1204       CYTOKINE SUPPRESSIVE ANTI-       INFLAMMATORY DRUG BINDING       PROTEIN; CSAID BINDING PROTEIN)       (CSBP); MAX-INTERACTING PROTEIN 2       (MAP KINASE MXI2)       chaperonin (HSP6O)   M34664   533-839       growth arrest and DNA-damage-inducible   M60974   526-886       protein (gadd45)       extracellular signal-regulated kinase 2   M84489   1241-1522       GADD153 = growth arrest and DNA-damage-   S40706; S62138   480-789       inducible       DNA-DEPENDENT PROTEIN KINASE   U35835; U47077   2250-2680       (DNA-PK) + DNA-PK CATALYTIC       SUBUNIT (XRCC7)       breast cancer susceptibility (BRCA2)   U43746   10056-10346       heat shock protein hsp86   X07270   380-577       heat shock protein HSP27   X54079   423-683       VIMENTIN   X56134 [M14144]   1164-1604       EXTRACELLULAR SIGNAL-   X60188    754-1094       REGULATED KINASE 1 (ERK1) protein       serine/threonine kinase (EC 2.7.1.-);       INSULIN- STIMULATED MAP2 KINASE;       MAP KINASE 1 (MAPK 1) (P44-ERK1)       (ERT2); MICROmBULE-ASSOCIATED       PROTEIN-2 KINASE (P44-MAPK)       EXTRACELLULAR SIGNAL-   X80692    806-1267       REGULATED KINASE 3 (EC 2.7.1.-)       (ERK3); MAP KINASE ISOFORM P97       (P97-MAPK)       sTRESS-ACTIVATED PROTEIN KINASE   L31951    638-1000       JNK2 (EC 2.7.1.-); C-JUN N-TERMINAL       KINASE 2 (JNK-55)       STRESS-ACTIVATED PROTEIN KINASE   U34819; U07620   1018-1413       JNK3 (EC 2.7.1.-); C-JUN N-TERMINAL       KINASE 3 (JNK3); MAP KINASE P49 3F12       heat shock protein (HSP 70)   M11717   1962-2225       DNA damage repair and recombination   U12134   1528-1733       protein RAD52       ataxia telangiectasia (ATM)   U33841   8938-9135       DUAL-SPECIFICITY MITOGEN-   U39657   1060-1389       ACTIVATED PROTEIN KINASE KINASE       6 (EC 2.7.1.-); MAP KINASE KINASE 6)       (MAPKK 6); MAPKIERK KINASE 6       (SAPKK3)       Rad50 (Rad50)   U63139   5117-5435       DNA ligase IV;   X83441   2787-3074       POLYDEOXYRIBONUCLEOTIDE       SYNTHASE (ATP)       DNA ligase III;   X84740   2460-2780       POLYDEOXYRIBONUCLEOTIDE       SYNTHASE (ATP)       MUSCLE-SPECIFIC DNASE I-LIKE   X90392; L40817; U06846   2038-2427       (DNase X)       cdc42 homolog (G25K) [brain isoform +   M35543; [M57298]   295-494       placental isoform]       p21-activated protein kinase (Pak2)   U24153   335-671       EXTRACELLULAR SIGNAL-   U25278   1010-1267       REGULATED KINASE 5 (EC 2.7.1.-)       (ERK5) (ERK4) (BMK1 KINASE)       MITOGEN-ACTIVATED PROTEIN   U53442   1119-1356       KINASE P38 BETA (EC 2.7.1.-) (MAP       KINASE P38 BETA)       FKBP-RAPAMYSIN ASSOCIATED   L34075   6750-7088       PROTEIN (FRAP)       EXTRACELLULAR SIGNAL-   X59727   2678-2994       REGULATED KINASE 4 (EC 2.7.1.-)       (ERK4) (MAP KINASE 1SOFORM P63)       (P63-MAPK).       EXTRACELLULAR SIGNAL-   X79483   530-831       REGULATED KINASE 6 (EC 2.7.1.-)       (ERK6) (ERK5)       PCNA (CYCLIN)   M15796; [J04718]   157-436       MEKKINASE3   U78876   1195-1453       BCL-2 BINDING ATHANOGENE-1 (BAG-   583171; [Z35491]   511-830       1) (GLUCOCORTICOID RECEPTOR-       ASSOCIATED PROTEIN RAP46).       C-fos   K00650   2949-3181       DUAL SPECIFICITY MITOGEN-   L11285   344-687       ACTIVATED PROTEIN KLIINASE KINASE       2 (EC 2.7.1.-) (MAP KINASE KINASE 2)       (MAPKK 2) (ERK ACTIVATOR KINASE       2) (MAPKJERK KIINASE 2) (MEK2).       DUAL SPECIFICITY MITOGEN-   U25265   603-845       ACTIVATED PROTEIN KINASE KINASE       5 (EC 2.7.1.-) (MAP KINASE KTNASE 5)       (MAPKK 5) (MAPK/ERK KINASE 5).       glutathione-S-transferase homolog   U90313    97-345       DNA MISMATCH REPAIR PROTEIN   U04045; [L47583]   2152-2365       MSH2       DNA MISMATCH REPAIR PROTEIN   U54777   2200-2475       MSH6 (mutS - ALPHA 160 KD SUBUNIT)       (G/T MISMATCH BINDING PROTEIN)       (GTBP) (GTMBP) (P160)       NUCLEOSIDE DIPHOSPHATE KINASE A   X17620   245-492       (EC 2.7.4.6) (NDK A) (NDP KINASE A)       (TUMOR METASTATIC PROCESS-       ASSOCIATED PROTEIN) (METASTASIS       INHIBITION FACTOR NM23) (NM23-H1).       NCK, ASH AND PHOSHPHOLIPASE C   AB005216   1003-1274       GAMMA-BINDING PROTIEN       NAP4(AB0052 16)       DNA POLYMERASE BETA (DPOB)   D29013    812-1103       DNA TOPOISOMERASE II, BETA   X68060   3597-3877       (TOP2B)       DIMETHYLANILINE   Z11737   1364-1641       MONOOXYGENASE (N-OXIDE       FORMING) 4 (EC 1.14.13.8) (HEPATIC       FLAVIN-CONTAINING       MONOOXYGENASE 4) (FMO 4)       (DIMETHYLANILINE OXIDASE 4)       DNA-REPAIR PROTEIN   L77890   1998-2269       COMPLEMENTING XP-F CELLS       (XERODERMA PIGMENTOSUM GROUP       F COMPLEMENTING PROTEIN) (DNA       EXCISION REPAIR PROTEIN ERCC-4)       78 KD GLUCOSE REGULATED PROTEIN   M19645   675-977       PRECURSOR (GRP 78)       (IMMUNOGLOBULIN HEAVY CHAIN       BINDING PROTEIN) (BIP)       V(D)J RECOMBINATION ACTIVATING   M94633   1296-1644       PROTEIN 2 (RAG2) (RAG-2)       DNA MISMATCH REPAIR PROTEIN   U13695   183-419       PMSl (PMSI PROTEIN HOMOLOG 1)       DNA MISMATCH REPAIR PROTEIN   U13696   2354-2579       PMS2 (PMS 1 PROTEIN HOMOLOG 2)       REPLICATION PROTEIN A 30 KD   U24186   135-424       SUBUNIT (RP-A) (RE-A) (REPLICATION       FACTOR-A PROTEIN 4)       mutY HOMOLOG (HMYH)   U63329   124-370       BETA CRYSTALLIN A4 (H5U59057).   U59057   229-570       T-COMPLEX PROTEIN 1, EPSILON   D43950   326-610       SUBUNIT (TCP- 1 -EPSILON)(CCT-       EPSILON) (HUMKGI DD)       BETA CRYSTALLIN BI (CRYBB1)   U35340   229-481       (H5U35340).       BETA CRYSTALLIN B2 (BP)   L10035   270-593       (HUMCRYB2B).       BETA CRYSTALLIN B3 (9CRYBB3 OR   U71216   163-375       CRYB3) (H5U71216).       B LYMPHOCYTE GERMINAL CENTER   U07349   137-398       KINASE (HSU07349)       CYTOCHROME P450 IIA6 (EC 1.14.14.1)   M33318; [X13930;   1007-1332           X13897];       (COUMARIN 7-HYDROXYLASE) (11A3)   M33317       (P450(I)) (PHENOBARIBITAL-       iNDUCIBLE)       CYTOCHROME P450 11A7 (EC 1.14.14.1)       (P450-IIA4)       CYTOCHROME P450 11C9 (EC 1.14.14.1)   M21940; M15331;   627-917       (P450 PB-I) (P450 MP-4) (S-   [M21939]M61858;           [L07093];       MEPHENYTOIN 4-HYDROXYLASE) +   M61853; M61854       CYTOCHROME P450 IIC10 (EC 1.14. 14.1)       (P450 MP-8) (8-MEPHENYTOIN 4-       ITYDROXYLASE) (FRAGMENT)       INTERFERON-INDUCIBLE RNA-   M35663; [U50648]   758-984       DEPENT)ENT PROTEiN KINASE (P68       KINASE)       10 KD HEAT SHOCK PROTEIN,   U07550   101-385       MITOCHONDRIAL (HSP 10) (10 KD       CHAPERONIN) (CPN 10).       HEAT SHOCK PROTEIN 27 (heart)   U15590   502-768       PROTEIN DISULFIDE ISOMERASE PS   D49489   1118-1397       PRECURSOR (EC 5.3.4.1) (HUMPS).       HEAT SHOCK PROTEIN HSP 90-BETA   M16660   135-386       (HSP 84) (HSP 90)       HEAT SHOCK 70 KD PROTEIN 6 (HEAT   X51757; M11236   1814-2229       SHOCK 70 KD PROTEIN B′). HEAT       SHOCK 70 KD PROTEIN 7 (HEAT SHOCK       70 KD PROTEIN B) (FRAGMENT).       HEAT SHOCK COGNATE 71 KD   Y00371   526-754       PROTEIN.       HEAT SHOCK-RELATED 70 KD   L26336   1246-1548       PROTEIN 2 (HEAT SHOCK 70 KD       PROTEIN 2).       CYTOCHROME P450 IIE1 (EC 1.14.14.1)   J02625   674-961       (P450-3) (ETHANOL INDUCIBLE) CYP2E1       CYTOCHROME P450 IIF1 (EC 1.14.14.1)   J02906   442-719       CYP2F1.       UDP-GLUCURONOSYLTRANSFERASE   J04093   444-677       1-6 PRECURSOR, MICROSOMAL (EC       2.4.1.17) (UDPGT) (UGT-IF) (UGT1*6)       (UGTI-06) (UGT 1.6) (UGT 1A6) (UGT1F)       (PHENOL SPECIFIC) UGTI OR GNTI.       GLUTATH10NE 5-TRANSFERASE MU 3   305459   252-479       (EC 2.5.1.18) (GSTM3-3) (CLASS-MU)       GSTM3 OR GST5.       CYTOCHROME P450 IAl (EC 1.14.14.1)   K03191    787-1029       (P450-P1) (P450 FORM 6) (P450-C) (TCDD-       INDUCIBLE).       PEROXISOME PROLIFERATOR   L02932   221-475       ACTIVATED RECEPTOR ALPHA (PPAR-       ALPHA) PPARA OR PPAR       PROTEIN DISULFIDE ISOMERASE-   D49490   1233-1548       RELATED PROTEIN PRECURSOR (EC       5.3.4.1) (PDIR) (HUMPDIR).       SOLUBLE EPOXIDE HYDROLASE (SEH)   L05779    913-1202       (EC 3.3.2.3) (EPOXIDE HYDRATASE)       (CYTOSOLIC EPOXIDE HYDROLASE)       (CEH) EPHX2.       LIVER CARIBOXYLESTERASE   L07765   1100-1342       PRECURSOR (EC 3.1.1.1) (ACYL       COENZYME A:CHOLESTEROL       ACYLTRANSFERASE) (ACAT)       (MONOCYTE/MACROPHAGE SERINE       ESTERASE) (HMSE) CES2.       SERUM   L48513    790-1071       PARAOXONASE/ARYLESTERASE 2 (EC       3.1.1.2) (EC 3.1.8.1) (PON 2) (SERUM       ARYLDIAKYLPHOSPHATASE 2) (A-       ESTERASE 2) (AROMATIC ESTERASE 2)       PON2.       SERUM   L48516   638-947       PARAOXONASE/ARYLESTERASE 3 (EC       3.1.1.2) (EC 3.1.81) (PON 3) (SERUM       ARYLDIAKYLPHOSPHATASE 3) (A-       ESTERASE 3) (AROMATIC ESTERASE 3)       (FRAGMENT) PON3.       CYTOCHROME P450 XXIB (EC   M12792; [M23280]   603-885       1.14.99.10) (STEROID 21-       HYDROXYLASE) (P450-C21B) CYP2IB       ORCYP21 ORCYP21A2.       CYTOCHROME P450 XIA1,   M14565   1076-1391       MITOCHONDRIAL PRECURSOR (EC       1.14.15.6) (P450(SCC)) (CHOLESTEROL       SIDE-CHAIN CLEAVAGE ENZYME)       (CHOLESTEROL DESMOLASE)       CYPi lAl.       CYTOCHROME P450 11D6 (EC 1.14.14.1)   M20403   899-1169       (P450-DB1) (DEBRISOQUINE 4-       HYDROXYLASE) CYP2D6.       UDP-GLUCURONOSYLTRANSFERASE   M57899    788-1019       1-1 PRECURSOR, MICROSOMAL (EC       2.4.1.17) (UDPGT) (UGT- IA) (UGT1*1)       (UGT1-01) (UGTI.1) (UGT1A1)       (BILIRUBIN SPECIFIC ISOZYME 1)       (UGTIA) (IIUG-BRi) UGTI OR GNT1.       UDP-GLUCURONOSYLTRANSFERASE   M57951   393-661       1-4 PRECURSOR, MICROSOMAL (EC       2.4.1.17) (UDPGT) (UGT- ID) (UGT 1*4)       (UGT 1-04) (UGT1 .4) (UGTIA4) (UGT1D)       (BILIRUBIN SPECIFIC ISOZYME 2)       (HUG-BR2) UGT1 OR GNT1.       STE20-LIKE KIINASE OXIDANT STRESS   D63780   424-711       KINASE (YSK1, STE20 and SPS1       RELATED KINASE)       SERUM   M63012    843-1099       PARAOXONASE/ARYLESTERASE 1 (EC       3.1.1.2) (EC 3.1.8.1) (PON 1) (SERUM       ARYLDIAKYLPHOSPHATASE 1) (A-       ESTERASE 1) (AROMATIC ESTERASE 1)       PONI OR PON.       CATECHOL 0-METHYLTRANSFERASE,   M65212   481-742       MEMBRANE-BOUND FORM (EC 2.1.1.6)       (MB-COMT) (CONTAINS: CATECHOL 0-       METHYLTRANSFERASE, SOLUBLE       FORM (S-COMT)) COMT.       AMINE OXIDASE (FLAYIN-   M68840   268-516       CONTAINING) A (EC 1.4.3.4)       (MONOAMINE OXIDASE) (MAO-A)       MAOA.       AMINE OXIDASE (FLAVIN-   M69177   130-358       CONTAINING) B (EC 1.4.3.4)       (MONOAMINE OXIDASE) (MAO-B)       MAOB.       EUKARYOTIC PEPTIDE CHAIN   M75715   441-673       RELEASE FACTOR SUBUNIT 1 (ERF1)       (TB3-1) (Cli PROTEIN) RFI.       UDP-GLUCURONOSYLTRANSFERASE   M84127   110-380       1-3 PRECURSOR, MICROSOMAL (BC       2.4.1.17) (UDPGT) (UGT-1C) (UGT1*3)       (UGT 1-03) (UGT 1.3) (UGT 1A3) (UGT1 C)       UGTI ORGNT1.       STRUCTURE-SPECIFIC RECOGNITION   M86737   695-933       PROTEIN 1 (SSRPI) (RECOMBINATION       SIGNAL SEQUENCE RECOGNITION       PROTEIN) (T160) SSRPI.       IJDP-GLUCURONOSYLTRANSFERASE   S55985   546-773       1-2 PRECURSOR, MICROSOMAL (BC       2.4.1.17) (UDPGT) (UGT-1B) (UGT1*2)       (UGT 1-02) (UGT1 .2) (UGTI A2) (UGT iB)       (HLUGP4) UGT 1 OR GNT 1.       TH10PURJNE 5-METHYLTRANSFERASE   S62904   154-423       (EC 2.1.1.67) (TH10PURTh4E       METI{YLTRANSFERASE) TPMT.       MELOTIC RECOMBINATION PROTEIN   D63882   573-898       DMC1/LIM15 HOMOLOG       ACYL-COA DEHYDROGENASE,   U12778   668-904       SHORT/BRANCHED CHAIN SPECIFIC       PRECURSOR (EC 1.3.99.-) (SBCAD) (2-       METHYL BRANCHED CHAIN ACYL-       COA DEHYDROGENASE) (2-MEBCAD)       ACADSB.       ARYLAMINE N-ACETYLTRANSFERASE,   X14672; X17059    800-1082       POLYMORPHIC (EC 2.3.1.5) (PNAT)       ARYLAMINE N-ACETYLTRANSFERASE,       MONOMORPHIC (EC 2.3.1.5) (MNAT)       GLUTATH10NE PEROXIDASE-   X53463   369-595       GASTROINTESTINAL (EC 1.11.1.9)       (GSHPX-GI) (GLUTATH10NE       PEROXIDASE-RELATED PROTEIN 2)       (GPRP) GPX2.       CYTOCHROME P450 XIB1 PRECURSOR   X55764   351-614       (P450C1 1) (STEROID 11-BETA-       HYDROXYLASE) (EC 1.14.15.4) CYPI IBi       OR SI 1BH.       CYTOCHROME P450 IVAI 1 (EC 1.14.14.1)   X71480   148-385       (FRAGMENT) CYP4A-1 1.       BLEOMYCIN HYDROLASE (EC 3.4.22.-)   X92106   1171-1408       (BLM HYDROLASE).       NADH-CYTOCHROME B5 REDUCTASE   Y09501   307-556       (EC 1.6.2.2) (B5R) DIAl.       COPROPORPHYRINOGEN III OXIDASE   Z28409   602-982       PRECURSOR (EC 1.3.3.3)       (COPROPORPHYRINOGENASE)       (COPROGEN OXIDASE) (COX) CPO.       HEAT-SHOCK PROTEIN 110 KD   D86956    903-1153       (KIAAO20 1)       GAMMA CRYSTALLIN C (GAMMA   U66582; M11971;    5-249       [M11970]       CRYSTALLIN 2 OR ⅓) (CRYGC) OR       (CRYG3). GAMMA CRYSTALLIN B       (GAMMA CRYSTALLIN 1-2) (CRYGB)       OR (CRYG2) (HUMCRYGX1).       HEAT SHOCK TRANSCRIPTION   D87673   542-794       FACTOR 4.       CYTOCHROMEP450IVB1 (EC 1.14.14.1)   J02871   1015-1273       (P450-HP)       EXTRACELLULAR SUPEROXIDE   J02947    870-1150       DISMUTASE PRECURSOR (CU-ZN) (EC       1.15.1.1) (EC-SOD) 50D3.       DNAJ PROTEIN HOMOLOG 2 (DNAJ2   D13388    798-1095       OR HDJ2)       DNA MISMATCH REPAIR PROTEIN   J04810   2807-3170       MSH3 (DIVERGENT UPSTREAM       PROTEIN) (MISMATCH REPAIR       PROTEIN 1) (MRP1) (DUP) (DUG)       PROTEIN DISULFIDE ISOMERASE-   J05016   1009-1263       RELATED PROTEIN PRECURSOR       (ERP72)       REPLICATION PROTEIN A 32 KD   J05249   195-420       SUBUNIT (RP-A) (RE-A) (REPLICATION       FACTOR-A PROTEIN 2)       MU-CRYSTALLIN HOMOLOG (CRYM)   L02950   420-714       (HUMMUCRYS).       MULTIDRUG RESISTANCE-   L05628   1891-2137       ASSOCIATED PROTEIN I       REPLICATION PROTEIN A 14 KD   L07493    30-256       SUBUNIT (RP-A) (RE-A) (REPLICATION       FACTOR A PROTEIN 3)       CALNEXIN PRECURSOR (MAJOR   L10284; [L18887; M94859;   1146-1380       HISTOCOMYATIBILITY COMPLEX   M98452]       CLASS 1 ANTIGEN-BINDING PROTEIN       P88) (P90) (1P90)       CYCLOPHILIN.A0   L11667   431-720       HEAT SHOCK 70 KD PROTEIN 4   L12723   1606-1994       (HSP7ORY).       QUINONE OXIDOREDUCTASE (EC   L13278; [S58039]    11-261       1.6.5.5) (NADPH:QUINONE REDUCTASE)       (ZETA-CRYSTALLIN).       T-COMPLEX PROTEIN 1, THETA   D13627   1025-1264       SUBUNIT (TCP- 1 -THETA)(CCT-THETA)       (HUMRSC548).       REGULATED PROTEIN) (GRE 75)   L15189   289-543       (PEPTIDE-BINDING PROTEIN 74)       (PBP74) (MORTALIN) (MOT).       P23 PROGESTERONE RECEPTOR   L24804; [L24805]   240-649       ASSOCIATED PROTEIN (HUMPRA)       FLAP ENDONUCLEASE.1   L37374   559-794       (MATURATION FACTOR 1) (MF1) (FEN-       1)       DNA NUCLEOTIDYLEXOTRANSFERASE   M11722   1555-1843       (TERMINAL ADDITION ENZYME)       (TERMINAL       DEOXYNUCLEOTIDYLTRANSFERASE)       (TERMINAL TRANSFERASE) (DNTT)       (TDT)       POLY (ADP-RIBOSE) POLYMERASE   M18112   2663-2900       (PARE) (ADPRT) (NAD (+) ADP-       RIBOSYLTRANSFERASE) (POLY (ADP-       RIBOSE) SYNTHETASE) (PPOL)       V(D)J RECOMBINATION ACTIVATING   M29474    841-1145       PROTEIN 1 (RAG1) (RAG-1)       FK506-BINDING PROTEIN (FKBP)   M34539; [M80199;   302-565       (FKBP 12) (PEPTIDYL-PROLYL CIS-   M80706; M92423; J05340;       TRANS ISOMERASE) (PPIASE)   X55741; X52220]       (ROTAMASE)       DNA LIGASE I   M36067   1739-2049       (POLYDEOXYRIBONUCLEOTIDE       SYNTHASE (ATP)) (DNL1) (LIG1)       RAPAMYC1N-BINDTNG PROTEIN (FKBP-   M65128   135-370       13)       DNA-REPAIR PROTEIN   D14533   1086-1316       COMPLEMENTING XP-A CELLS       (XERODERMA PIGMENTOSUM GROUP       A COMPLEMENTING PROTEIN)       HEAT SHOCK FACTOR PROTEIN 2 (11SF   M65217   1437-1671       2) (HEAT SHOCK TRANSCRIPTION       FACTOR 2)(HSTF 2).       DNA-3 METHYLADENINE   M74905   459-699       GLYCOSYLASE (3-METHYLADENINE       DNA GLYCOSYLASE) (ADPG) (3-       ALKYLADENINE DNA GLYCOSYLASE)       (N-METHYLPURINE-DNA       GLYCOSIRASE) (MPG) (MAGI) (3MeAG)       DNA POLYMERASE DELTA CATALYTIC   M80397   1629-1913       CHAIN       CALRETICIJLIN PRECURSOR (CRP55)   M84739   214-501       (CALREGULIN) (HACBP) (ERP6O)(52 KD       RIBONUCLEOPROTEIN AUTOANTIGEN       RO/SS-A)       TRANSFORMATION -SENSITIVE   M86752   1333-1646       PROTEIN (LEF SSP 3521)       ALPHA CRYSTALLIN B CHAIN   S45630   368-669       (ALPHA(B)-CRYSTAILIN) (ROSENTHAL       FIBER COMPONENT).       HEAT SHOCK PROTEIN H5P72   S67070    69-378       HOMOLOG (FRAGMENT).       ALPHA CRYSTALLIN A CHAIN   U05569    54-374       (H5U05569).       NICOTINAMIDE N-   U08021   124-385       METHYLTRANSFERASE (EC 2.1.1.1)       IJDP-GLUCURONOSYLTRANSFERASE   U08854; X63359; U06641;   1268-1509       2B15 PRECURSOR, MICROSOMAL (EC   105428; Y00317       2.4.1.17) (UDPGT) (UDPGTH-3) UGT2B15.       UDP-GLUCURONOSYLTRANSFERASE       2B10 PRECURSOR, MICROSOMAL (EC       2.4.1.17) (UDPGT) UGT2B 10. UDP-       GLUCURONOSYLTRANSFERASE 2B8       PRECURSOR, MICROSOMAL (EC       2.4.1.17)       PROBABLE PROTEIN DISULFIDE   D16234; [Z49835; D83485;    788-1019       ISOMERASE ER-60 PRECURSOR (EC   U42068]       5.3.4.1) (ERP6O) (58KDA MICROSOMAL       PROTEIN) (phospholipase C-alpha)       PHENOL-SULFATING PHENOL   U09031; U28170; L19956   202-465       SULFOTRANSFERASE 1 (EC 2.8.2.1) (P-       PST) (THERMOSTABLE PHENOL       SULFOTRANSFERASE) (TS-PST)       (HAST1/HAST2) (ST1A3) STP1 OR STP.       PHENOL-SULFATING PHENOL       SULFOTRANSFERASE 2 (EC 2.8.2.1) (P-       PST) (ST1A2) STP2. MONOAMINE-       SULFATING PHENOL SU       DIHYDROPYRIMIDINE   U09178   2257-2590       DEHYDROGENASE (NADP+)       PRECURSOR (EC 1.3.1.2) (DPD)       (DIHYDROURACIL DEHYDROGENASE)       (DIHYDROTHYMINE       DEHYDROGENASE) DPYD.       X-LINKED HELICASE II (X-LINKED   U09820   4521-4849       NUCLEAR PROTEIN) (XNP) (RAD54L)       (XH2)       TUMOR NECROSIS FACTOR TYPE 1   U12595    716-1013       RECEPTOR ASSOCIATED       PROTEIN(TRAP l)(HSU 12595)       TUMOR NECROSIS FACTOR TYPE 1   U12596   1882-2202       RECEPTOR ASSOCIATED       PROTEIN(TRAP2) (HSUI 2596)       DAMAGE-SPECIFIC DNA BINDING   U18299   371-645       PROTEIN piT? SUBUNIT; IMPLICATED       iN XERODERMA PIGMENTOSUM       GROUP E (DDBI)       DAMAGE-SPECIFIC DNA BINDING   U18300   1042-1316       PROTEIN p48 SUBUNIT; IMPLICATED IN       XERODERMA PIGMENTOSUM GROUP E       (DDB2)       COCKAYNE SYNDROME GROUP A; WD-   U28413   296-599       REPEAT PROTEIN (CSA PROTEIN)       HSC70-1NTERACTING PROTEIN   U28918   493-737       (PROGESTERONE RECEPTOR-       ASSOCIATED P48 PROTEIN)       T-COMPLEX PROTEIN 1, DELTA   U38846   1063-1356       SUBUNIT (TCP- I-DELTA)(CCT-DELTA)       (STIMULATOR OF TAR RNA BINDING)       (H5U38846).       7,8-DIHYDRO-8-OXOGUANINE   D16581   221-455       TRIPHOSPHATASE (mutT       HOMOMOLOG) (8-OXO-DGTPASE)       (MTH1)       DNA REPAIR PROTEIN XRCC4   U40622   718-969       DNA TOPOISOMERASE III (TOP3) U43431   1534-1785       G/T MISMATCH-SPECIFIC THYMINE   U51166    830-1093       DNA GLYCOSYLASE (TDG)       150 KDA OXYGEN-REGULATED   U65785   1471-1761       PROTEIN ORP 150 (HSU65785)       DNA REPAIR PROTEIN XRCC9   U70310   1715-2008       48 kDa FKBP-ASSOCIATED PROTEIN   U73704    954-1228       FAP48       ENDONUCLEASE III HOMOLOG 1   U79718   192-455       (HNTH1) (OCTS3)       T-COMPLEX PROTEIN 1, ETA SUBUNIT   U83843    885-1144       (TCP-1-ETA) (CCT-ETA)(HIV-1 NEF       INTERACTING PROTEIN) (HSU83843).       CATALASE (EC 1.11.1.6) CAT.   X04076   957-1214       PORPHOBILINOGEN DEAMINASE (EC   X04808   736-998       4.3.1.8) (HYDROXYMETHYLBILANE       SYNTHASE) (HMBS) (PRE-       UROPORPHYRINOGEN SYNTHASE)       DNA-REPAIR PROTEIN   D21089   1767-2092       COMPLEMENTING XP-C CELLS       (XERODERMA PIGMENTOSUM GROUP       C COMPLEMENTING PROTEIN) (p 125)       HEME OXYGENASE 1 (EC 1.14.99.3) (HO-   X06985    791-1056       1) (HSOXYGR).       SUPEROXIDE DISMUTASE PRECURSOR   X07834; [X59445]    89-348       (MN) (EC 1.15.1.1) 50D2       ENDOPLASMIN PRECURSOR (94 KD   X15187; [M33716]   1357-1645       GLUCOSE-REGULATED       PROTEIN)(GRP94) (GP96 HOMOLOG)       (TUMOR REJECTION ANTIGEN 1)       (LISTRAI).       URACIL-DNA GLYCOSYLASE   X15653   547-772       PRECURSOR (UNGl)       NCK MELANOMA CYTOPLASMIC SRC   X17576   404-675       HOMOLOGUE (HSNCK)       5,6-DIHYDROXYINDOLE-2-   X51420    909-1145       CARBOXYLIC ACID OXIDASE       PRECURSOR (DHICA OXIDASE)       (TYROSINASE-RELATED PROTEIN 1)       (TRP-1) (CATALASE B)       (GLYCOPROTEIN-75) (GP75)       URACIL-DNA GLYCOSYLASE 2 (UNG2)   X52486    882-1118       T-COMPLEX PROTEIN 1, ALPHA   X52882    993-1336       SUBUNIT (TCP-1-ALPHA)(CCT-ALPHA)       CCT1 OR CCTA OR TCP1       40S RIBOSOMAL PROTEIN S3   X55715   315-621       (POSSIBLE dRpase)       DNA-(APURINIC OR APYRIMIDINIC   X59764; [X66133]   524-768       SITE) LYASE (AP ENDONUCLEASE 1)       (APEX NUCLEASE) (APEN) (REF-1       PROTEIN) (APEl)       HEME OXYGENASE 2 (EC 1.14.99.3) (HO-   D21243; [S34389]   508-763       2)       47 KD HEAT SHOCK PROTEIN   X61598; D83174   539-777       PRECURSOR (COLLAGEN-BINDING       PROTEIN 1) (COLLIGIN 1) + Collagen       binding protein 2 (HUMCBP2).       T-COMPLEX PROTEIN 1, GAMMA   X74801; [U17104]    32-270       SUBUNIT (TCP- 1 -GAMMA)(CCT-       GAMMA) (CCT3) OR (CCTG) OR (TRICS)       (I- SHUMAPC).       DNA REPAIR PROTEIN RAD54   X97795   1001-1284       HOMOLOG       BASIC TRANSCRIPTION FACTOR 2,52   Y07595   466-830       KD SUBUNIT (BTF2pS2)       RAD5 1-LIKE PROTEIN (POSSIBLE   Y08837   203-266       XRCC2)       8-OXYGUANINE DNA GLYCOSYLASE   Y11838   380-646       HOMOLOG 1 (mutM HOMOLOG) (OGH1)       (HOGGI) (FaPyG)       CYTOCHROME P450 1A2 (EC 1.14.14.1)   Z00036   1221-1509       (P450-P3) (P450-4).5 15       BASIC TRANSCRIPTION FACTOR 2,34   Z30093   585-899       KD SUBUNIT (BTF2p34)       DIMETHYLANILINE   L37080   1086-1376       MONOOXYGENASE (N-OXIDE       FORMING) 5 (EC 1.14.13.8) (HEPATIC       FLAVIN-CONTAINING       MONOOXYGENASE 5) (FMO 5)       (DIMETHYLANILINE OXIDASE 5)       UBIQUITJN-LIKE PROTEIN (NEDD8)   D23662   222-546       MULTIDRUG RESISTANCE PROTEIN 3   M23234   1798-2094       (P-GLYCOPROTE1N 3)       DIMETHYLANILINE   M64082   721-966       MONOOXYGENASE (N-OXIDE       FORMING) 1 (EC 1.14.13.8) (FETAL       HEPATIC FLAVIN-CONTAINING       MONOOXYGENASE 1) (FMO 1)       (DIMETHYLANILINE OXIDASE 1)       HHR6B (YEAST RAD6 HOMOLOG)   M74525   523-761       (UBIQITIN-CON.TUGATING ENZYME)       (UBCB)       IMMUNOPHILLIN (FKBP52)   M88279   554-837       HEAT SHOCK PROTEIN HSP40HEAT   U40992    13-300       SHOCK PROTEIN HSP40 HOMOLOG.       54 KDA PROGESTERONE RECEPTOR-   U42031    829-1147       ASSOCIATED PROTEIN FKBP54       HEMATOPOJETIC PROGENITOR   U66464   264-536       KINASE ACTIVATOR OF SAPK/JNK       (HPK1) (H5U66464)       SPS1/STE20 HOMOLOGUE, KHS,   U77129   1376-1633       ACTIVATOR OFJUN N-TERMINAL       KINASE (H5U77 129)                  
 
     EXAMPLE 2  
     Alternative Human Stress Array  
     [0068] An alternative array to that described in Example 1 displays probes obtained from the list of genes appearing in Table 2.  
                           TABLE 2                       Clon ID   Gene Name   Gen Bank Acc #   Sprot Acc #                      interleukin 7 receptor alpha subunit (IL7R-alpha;                1   IL7RA); CDW127 antigen   M29696   P16871        4   myc proto-oncogene   V00568   P01106; P01107           interleukin 2 receptor alpha subunit (IL2 receptor   X01057; X01058;        5   alpha; IL2RA); TAG antigen; CD25 antigen   X01402   P01589        9   insulin-like growth factor II (IGF2); somatomedin A   M29645   P01344           tumor necrosis factor receptor superfamily member           1B (TNFRSF1B); tumor necrosis factor receptor 2           (TNFR2); tumor necrosis factor beta receptor        13   (TNFBR); CD120B antigen   M32315; M55994   P20333           p53-binding mouse double minute 2 homolog        14   (MDM2)   Z12020; M92424   Q00987; Q13226        19   interleukin 1 beta (ILl-beta; ILIB); catabolin   K02770   P01584        34   transforming growth factor beta (TGF-beta; TGFB)   X02812; J05114 P01137        37   mybproto-oncogene   M15024   P10242        38   p53 cellular tumor antigen   M14694; M14695   P04637           transforming growth factor beta 2 (TGF-beta 2;   M19154; M22045;        39   TGFB2)   M22046;Y00083   P08112; Q15581           interleukin 4 receptor alpha subunit (IL4R-alpha;        46   IL4RA); CD124 antigen   X52425   P24394           interferon aiphalbeta/omega receptor subunit 2        50   (IFN-alpha receptor 2; IFNAR2)   X77722   P48551           interferon gamma-induced monokine (MIG); small        51   inducible cytokine subfamily B member 9 (SCYB9) X72755   Q07325           interleukin 2 receptor gamma subunit (IL2R-           gamma; IL2RG); cytokine receptor common gamma        54   chain   D11086   P31785           interferon gamma receptor 1 (IFNR-gamma 1;        58   IFNGR1); immune interferon receptor 1   J03143   P15260        61   adenosine Al receptor (ADORA1)   556143   P30542        62   orphan hormone nuclear receptor   Z30425   Q14994        63   adenosine A3 receptor (ADORA3)   X76981   P33765        66   thrombin receptor (TR); F2R; PAR1   M62424   P25116           transforming growth factor beta receptor III (TGF        67   beta receptor III; TGFR3); betaglycan   L07594   Q03167        72   GATA-binding protein 2 (GATA2)   M68891   P23769           CCAAT-binding transcription factor subunit B           (CBFB); CBFA; NF-Y protein subunit A (NF-YA);        76   HAP2   M59079   P23511           retinoic acid receptor beta (RAR-beta; RARB);        77   hepatitis B virus-activated protein (HAP)   X07282; Y00291   P10826           MYB-related protein B (B-MYB); avian           myeloblastosis viral oncogene homolog-like 2        78   (MYBL2)   X13293   P10244        79   tyrosine kinase receptor tie-I   X60957; 589716   P35590        81   inhibitor of DNA-binding protein 3 (103); HEIR1   X69111   Q02535; 075641           basic transcription element-binding protein 2        83   (BTEB2); GC-box binding protein 2   014520   Q13887        84   basic transcription factor 62-kDa subunit (BTF2)   M95809   P32780        88   DNA-binding protein SMBP-2; glial factor-1 (GF-1)   L14754   P38935           SWI/SN F related matrix-associated actin-           dependent regulator of chromatin subfamily a           member 1 (SMARCA1); sucrose nonfermenting 2        90   homolog-like protein 1 (SN F2L1)   M881 63   P28370           interferon consensus sequence-binding protein        96   (ICSBP)   M91196   Q02556        98   CACCC-box DNA-binding protein   L04282   Q15552       104   activating transcription factor 3 (ATF3)   L19871   P18847           neurotrophic tyrosine kinase receptor-related 3;       107   TKT   X74764   Q16832       109   prostaglandin E2 receptor EP4 subtype (PTGER4)   L25124; D28472   P35408           thyroid hormone receptor alpha 2 (THRA2); erbA       119   alpha2proto-oncogene   J03239   P10827       123   amino-terminal enhancer of split (AES)   X73358   Q08117; Q12808           DNA-binding protein HIPI16; ATPase; SNF2/SW12-       124   related protein   L34673   Q14527           zinc finger protein 9 (ZFN9); cellular nucleic acid-       127   binding protein (CNBP)   M28372   P20694           v-erbA related protein 3 (EAR3); transcription factor           COUP2 (TFCOUP2); nuclear receptor subfamily 2   Xl 2795; Xl 6155;       129   group F member 2 (NR2F2)   X58241   P10589           cut-like protein 1 (CUTL1); CCAAT displacement       130   protein (CDP)   L12579   Q13948           basic transcription factor 244-kDa subunit       132   (BTF2p44)   Z30094   Q13888           signal transducer and activator of transcription 3       134   (STAT3); acute-phase response factor (APRF)   L29277   P40763           SWI/SN F-related matrix-associated actin-           dependent regulator of chromatin subfamily A           member 4 (SMARCA4); sucrose nonfermenting 2           homolog-like 4 (SNF2L4); brahma-related gene 1       136   (BRGI)   D26156   P51532       142   transcriptional repressor NF-X1   U15306   Q12986           transcription factor DP2 (Humdp2); E2F       143   dimerization partner 2   U18422   Q14188; Q14187       144   glia maturation factor beta (GMF-beta; GMFB)   M86492   P17774           cAMP-responsive element-binding protein 1       147   (CREB1)   L05515   Q02930; Q05886           protein-tyrosine phosphatase gamma (R-PTP-       149   gamma)   L09247   P23470           activator 1140-kDa subunit (A1 140-kDa subunit);           replication factor C large subunit; DNA-binding       151   protein PO-GA   L14922   P35251           heat shock transcription factor 1 (HSTF1; HSF1);       152   transcription factor 5 (TCF5)   M64673   Q00613       153   c-jun proto-oncogene   J04111   P05412           interleukin 1 receptor type 1 (IL1R1); IL1R-alpha;       154   p80;CDW121Aantigen   M27492   P14778           macrophage-specific colony-stimulating factor       156   (CSF-1; MOSE)   M37435   P09603           insulin-like growth factor 2 receptor (IGF2R); cation-           independent mannose-6-phosphate receptor       158   (MPIR)   Y00285; J03528   P11717           CXC chemokine receptor type 4 (CXCR4); stromal           cell-derived factor 1 receptor (SDF1 receptor);           fusin; leukocyte-derived seven transmembrane       164   domain receptor (LESTR); LCR1   D10924   P30991; P56438           CC chemokine receptor type 1 (CMKBRI;           CCCKR1; CCR1); macrophage inflammatory           protein 1 alpha receptor (MIP1-alpha receptor;       165   MIPI-alphaR)   D10925   P32246           macrophage inflammatory protein 1 beta (MIP1-           beta); T-cell activation protein 2 (AT2); PAT 744;           H400; SIS-gamma; lymphocyte activation gene 1           protein (LAG 1); HC21; small inducible cytokine           subfamily A member 4 (SCYA4); G 26 T-       P13236; P22617;       171   lymphocyte secreted protein   J04130   Q13704           glucose-6-phosphate isomerase (GPI); neuroleukin           (NLK); phosphoglucose isomerase (PGI);       174   phosphohexose isomerase (PHI)   K03515   P06744           angiopoietin 1 receptor; tyrosine-protein kinase           receptor TIE-2; tyrosine-protein kinase receptor           TEK; p140 TEK; tunica interna endothelial cell       175   kinase   L06139   Q02763       178   interleukin 13 (IL13)   L06801   P35225       187   thrombopoietin (THPO); megakaryocyte colony   L36052; L36051;   P40225           stimulating factor; c-mpl ligand; megakaryocyte   U11025           growth &amp; development factor (MGDF)           uromodulin; Tamm-Horsfall urinary glycoprotein       193   (THP)   M17778   P07911           platelet-derived growth factor receptor alpha       196   (PDGFR-alpha; PDGFRA); CD14QA antigen   M21574   P16234           platelet-derived growth factor receptor beta subunit       197   (PDGFR-beta; PDGFRB); CD140B antigen   M21616   P09619           bone morphogenetic protein 1 (BMPI); procollagen       198   C proteinase 2 (PCP2)   M22488; U50330   P13497; Q13292       199   bone morphogenetic protein 2A (BMP2A)   M22489   P12643           macrophage inflammatory protein 1 alpha (MIP1-           alpha); tonsillar lymphocyte LD78 alpha protein;           GOS19-1 protein; PAT 464.2; SIS-beta; small       201   inducible cytokine subfamily A member 3 (SCYA3)   M23452   P10147; P16619           small inducible cytokine subfamily A member 2           (SCYA2); monocyte chemotactic protein 1 (MCP1);       202   monocyte chemotactic &amp; activating factor (MOAF)   M24545   P13500           insulin-like growth factor binding protein 1 (IGF-           binding protein 1; IGFBPI); placental protein 12       208   (PP12)   M31145   P08833           tumor necrosis factor alpha-induced protein 6       209   (TNFAIP6); TSG6   M31165   P98066           vascular endothelial growth factor (VEGF); vascular       210   permeability factor (VPF)   M32977; M27281   P15692           insulin-like growth factor-binding protein 2 (IGF-       211   binding protein 2; IGFBP2; IBP2)   M35410   P18065; Q14619           ribon uclease/angiogenin inhibitor (RAI; RN H);       212   placental ribonuclease inhibitor   M36717   P13489           fibroblast growth factor receptori (FGFRI); basic   X66945; M34641;           fibroblast growth factor receptor (BFGFR); fins-like M34186; M37722;           tyrosine kinase 2 (FLT2); heparin-binding growth   M83887; M63888;   P11362; P17049;       214   factor receptor alpha A (HBGFR-alpha A)   M63889   Q02063; Q02065           plelotrophin (PTN); osteoblast specific factor 1           (OSF1); heparin-binding neurite growth-promoting           factor 1 (HBNF1; NEGF1); heparin-binding growth-           associated molecule (HB-GAM); heparin-binding   X52946; D90226;       216   growth factor 8 (HBGF8)   M57399   P21246           interleukin 11 (ILl1); adipogenesis inhibitory factor       218   (AGIF)   M57765   P20809           stem cell factor (SCF); mast cell growth factor       222   (MGF); c-kit ligand   M59964   P21583           tumor necrosis factor receptor superfamily member       235   7 (TNFRSF7); CD27L antigen receptor   M63928   P26842       247   thymosin beta 10 (TMSB10; THYB10); PTMB10   M92381   P13472       248   connective tissue growth factor (CTGF)   M92934   P29279       252   related to receptor tyrosine kinase (RYK)   S59184   P34925           Duffy blood group antigen; FY glycoprotein (GPFY);       255   glycoprotein D (GPD); DARC   U01839   Q16570; Q16300           SL cytokine; FMS-related tyrosine kinase 3 ligand       263   (FLT3 ligand; FLT3LG)   U04806; U03858   P49771           caspase 3 (CASP3); apopain; cysteine protease           GPP32; YAMA protein; SREBP deavage activity 1       266   protein (SCA1)   U13737   P42574           calgranulin A (GALA); migration inhibitory factor-           related protein 8 (MRP8); leukocyte LI complex           light chain; SiQO calcium-binding protein A8       276   (S100A8); cystic fibrosis antigen (OFAG)   X06234   P05109           platelet-derived growth factor A subunit (PDGFA;       277   PDGF1)   X06374   P04085           fins-related tyrosine kinase 1 (ELT1); vascular           endothelial growth factor receptor 1 (VEGERI);       P17948; P16057;       285   vascular permeability factor receptor   X51602   060722           placental growth factor (PLGF; PGF); vascular       290   endothelial growth factor-related protein   X54936   P49763           tumor necrosis factor receptor superfamily member       294   5 (TN FRSFS); 0040 antigen   X60592   P25942           corticotropin-releasing factor receptor 1 (CRFR;           GRE 1); corticotropin-releasing hormone receptor 1       296   (CRHR1)   X72304   P34998; Q13008                   P07602; P07292;           prosaposin (PSAP); variant Gaucher disease &amp;       P15793; P78538;           variant metachromatic leukodystrophy protein;       P78546; P78547;       301   sphingolipid activator protein 1 (SAP1); GLBA   D00422   Q92739       302   protein kinase G delta (PKC-delta)   D10495   015144           GA-binding protein alpha subunit (GABP-alpha;           GABPA); transcription factor E4TF1-47; nuclear       305   respiratory factor 2 alpha subunit   D13316   006546; 012939                   Q06545           GA-binding protein transcription factor alpha       307   subunit (GABPA); E4TFIA; E4TFI-60   013318   Q06546; Q12939           DNA damage repair &amp; recombination protein 51       308   homolog (RAD51)   D13804   006609           alpha 1 catenin (GTNNA1); cadherin-associated   Q13866; Q14705;       309   protein   L23805; L22080   P35221                   P41134; Q16377                   Q16371; Q00651;       310   inhibitor of DNA binding 1 protein (101)   D13889   Q00652                   P46966; P46968;       314   defender against cell death 1 protein (DAD1)   Q15057   Q08552; Q70364           TYRO3 tyrosine-protein kinase receptor; RSE;       316   SKY; DTK   Q17517   Q06418           bone marrow stromal antigen 1 (BST-1); ADP-           ribosyl cyclase 2; cyclic ADP-ribose hydrolase 2       317   (GADPR hydrolase 2); GD157 antigen   Q21878   Q10588       323   LIM domain kinase 1 (LIMKI)   Q26309   P53667           neuroblastoma suppression of tumorigenicity           protein 1 (NBL1); differential screening-selected       328   gene aberrant in neuroblastoma (DAN)   D28124   P41271           excision repair cross-complementing rodent repair           deficiency complementation group 6 (ERCC6);       334   Cockayne syndrome protein 2 type B (CSB)   L04791   Q03468           mitogen-activated protein kinase kinase 1 (MAP           kinase kinase I; MAPKKI; MAP2K1; PRKMK1);       335   MAPK/ERK kinase 1 (MEK1)   L05624   Q02750           replication factor C 36-kDa subunit (RFC36);       341   activator 1 36-kDa subunit   L07540   P40937           replication factor C 38-kDa subunit (RFC38);       342   activator 1 38-kDa subunit   L07541   P40938       344   MAX-interacting protein 1 (MXI1)   L07648   P50539; Q15887           sex-determining region Y protein (SRY); testis-       347   determining factor (TOF)   L10101   Q05066           MOESIN-ezrin-radixin-like protein (MERLIN); L11353; Z22664;       348   schwannomin (SCH); neurofibromatosis 2 (NF2)   X72657; L27133   P35240           focal adhesion kinase (FADK); proline-rich tyrosine       350   kinase 2 (PYK2)   LI 3616   Q05397       351   tyrosine-protein kinase ack   L13738   Q07912       352   early response protein NAKI; TR3 orphan receptor   L13740   P22736           RAR-related orphan receptor alpha (ROR-alpha;       353   RORA); RZRA   U04897; L14611   P35397; P45445           tight junction protein 1 (TJPI); zonula occludens       357   (ZOI)   L14837   Q07157           nucleoside diphosphate kinase B (NDP kinase B;           NDKB); expressed in non-metastatic cells 2 protein           (NME2); myc purine-binding transcription factor       359   (PUF); NM23B   L16785; M36981 P22392           relA proto-oncogene; nuclear factor of kappa light       360   polypeptide gene enhancer in B-cells 3 (NFKB3)   L19067   Q04206           xeroderma pigmentosum group G complementing           protein (XPG); X-ray repair-complementing           defective repair in Chinese hamster cells 5       365   (XRCC5)   L20046; X69978   P28715           serine/threonine-protein kinase NRK2;       367   serine/threonine kinase 2 (STK2)   L20321   P51957           ras-related associated with diabetes protein           (RRAD); ras associated with diabetes protein 1       374   (RAD1)   L24564   P55042           calcium/calmodulin-dependent protein kinase type       375   IV catalytic subunit (CAMK IV); CAM kinase-GR   L24959   Q16566           growth factor receptor-bound protein 2 (GRB2);   P29354; Q63057;       377   abundant SRC homology protein (ASH)   L2951 1; M96995   Q14450       378   nuclear factor l-X (NFI-X)   L31881   Q13050           mitogen-activated protein kinase kinase kinase 11           (MAPKKK11; MAP3K11); mixed lineage kinase 3       379   (MLK3); SPRK; protein tyrosine kinase 1 (PTKI)   L32976   Q16584           cyclin-dependent kinase 10 (CDKl 0); CDC2-related       380   protein kinase PISSLRE   L33264   Q15130; Q15131       381   RNA polymerase II elongation factor SIII p15   L34587   Q15369           subunit           guanine nucleotide-binding protein alpha       387   stimulating activity polypeptide 1 (GNASI)   M14631   P04895       391   T-lymphocyte maturation-associated protein MAL   M15800   P21145       393   homeobox protein B7 (HOXB7); HOX2C; HHO.C1   M16937   P09629; Q15957           INT-2 proto-oncogene protein (fibroblast growth       397   factor-3) (FGF-3) (HBGF-3)   M17446   P08620           B-lymphocyte CD19 antigen; B-lymphocyte surface       398   antigen B4; leu-12   M21097   P15391           protein kinase C alpha polypeptide (PKC-alpha;       399   PKCA)   M22199   Q15137           prothymosin alpha (PTMA); thymosin alpha       402   (TMSA)   M26708   Q15249; Q15592       406   ras-related protein RAB2   M28213   P08886           stem cell protein (SCL); T-cell leukemia/lymphoma-           5 protein (TOLS); T-cell acute lymphocytic       411   leukemia-I protein (TAL1)   M29038   P17542           Ku (p701p80) subunit; ATP-dependent DNA           helicase II 86-kDa subunit: lupus ku autoantigen           protein; thyroid-lupus autoantigen (TLAA); CTC box           binding factor 85-kDa subunit (CTCBF; CTC85);       417   nuclear factor IV   M30938   P13010           transcription factor E2-alpha (E2A); immunoglobulin           enhancer binding factor E12; transcription factor-3       420   (TCF3)   M31523   P15923           activating transcription factor 2 (ATF2); cAMP           response element DNA-binding protein 1       421   (CREBP1); HB16   M31630   P15336           xeroderma pigmentosum group B complementing           protein (XPB); excision repair cross-complementing           rodent repair deficiency complementation group 3           (ERCC3); basal transcription factor 2 89-kDa       422   subunit (BTF2p89; TFIIH 89-kDa subunit)   M31899   P19447           G22P1; Ku 70-kDa subunit (KU70); 70-kDa thyroid       424   autoantigen (TLAA)   M32865; S38729   P12956           cadherin 2 (CDH2); neural cadherin (N-cadherin;   M34064; X57548;       426   NOAD)   X54315; S42303   P19022; 014923       427   cAMP-response element binding protein 1 (CREBI) M34356   P16220; P21934           transcription initiation factor lID; TATA-box factor;       429   TATA sequence-binding protein (TBP)   M34960   Q16845           X-ray repair-complementing defective repair in       432   Chinese hamster cells 1 (XRCC1)   M36089   P18887           early growth response protein 1 (EGR1); KROX24;           nerve growth factor-induced clone A (NGFIA);       458   Z1F268; TIS8; G0S30   X52541; M62829   P18146       459   transcription factor ETR10l   M62831   Q03827           replication protein A 70-kDa subunit (RPA7O;           REPAI; RF-A); single-stranded DNA-binding       460   protein   M63488   P27694           aryl hydrocarbon receptor nuclear translocator       464   (ARNT); hypoxia-inducible factor 1 beta (HIFi-beta) M69238   P27540           retinoic acid receptor alpha (RAR-alpha; RARA);   X06538; X06614;   P1 0276; Q13440;       466   PML-RAR protein M73779   Q13441; Q15156           dipeptidyl peptidase IV (DPP IV; DPP4 ); T-cell           activation CD26 antigen; TPlO3; adenosine       469   deaminase complexing protein 2 (ADABP; ADCP2)   M74777   P27487           clusterin (CLU); complement-associated protein           SP-40; complement lysis inhibitor (CLI);           apolipoprotein J (APOJ); testosterone-repressed           prostate message 2 (TRPM2); sulfated glycoprotein   P10909; P11380;       470   2 (SGP2) M74816   P11381           transcriptional repressor protein yin &amp; yang 1 (YY1);           delta transcription factor; DNA-binding protein NF-       473   E1; UCRBP   M76541   P25490; Q14935           transcription factor HTF4; transcription factor 12       478   (TCF12); E-box-binding protein HEB   M80627   Q99081               M84820; X63522;       487   retinoic acid receptor beta (RXR-beta; RXRB)   S54072   P28702; P28703           activator 1 40-kDa subunit (Al 40-kDa subunit);       491   replication factor C 40-kDa subunit (RFC40); RFC2   M87338   P35250           activator 1 37-kDa subunit; replication factor C 37-       492   kDa subunit (RFC37); RFC4 M87339   P35249           interferon-stimulated gene factor 3 gamma subunit           (ISGF3 gamma; ISGF3G); interferon-alpha-           responsive transcription factor subunit (IFN-alpha-       493   responsive transcription factor subunit   M87503   Q00978           homeobox protein 2.1 (HOX2A); HOXB5; HU1;       497   HHO.C10   M92299   P09067; P09069           tristetraproline (TTP); TIS11; ZFP36; growth factor-       498   inducible nuclear protein 475 (NUP475)   M92843   P26651       499   flil proto-oncogene   M93255   Q01543           follicle-stimulating hormone receptor (FSHR);       500   follitropin receptor   M95489   P23945           special AT-rich sequence-binding protein 1       505   (SATB1)   M97287   Q01826           neuro epithelioma transforming gene 1 (NEP1;       511   NET1); guanine nucleotide regulatory protein   U02081   Q12773       512   guanine nucleotide regulatory protein tim 1   U02082   Q12774       513   neu differentiation factor   U02326   Q12780       526   cell division cycle 20 homolog (CDC20)   U05340   Q12834           interferon gamma (IFN-gamma) receptor beta           subunit; IFN-gamma accessory factor 1 (AE1); IFN-       527   gamma transducer 1 (IFNGT1)   U05875   P38484           proto-oncogene tyrosine-protein kinase Ick; p56-Ick;           lymphocyte-specific protein tyrosine kinase (LSK);       531   T-cell-specific protein-tyrosine kinase   U07236   P06239           epidermal growth factor receptor substrate 15       533   (EPS15); AF-1 P protein   U07707; Z29064   P42566           cytoplasmic nuclear factor of activated T-cells 1       536   (NF-ATC1)   U08015   Q12865           nuclear factor erythroid 2-related factor 1 (NFE2-           related factor 1); erythroid-derived 2 nuclear factor-           like 1 (NFE2L1; NRF1); transcription factor 11           (TOFu); HBZ17; locus control region factor 1       539   (LORF1)   U08853   Q14494; Q12877       540   serine kinase   U09564   Q12890           cyclin-dependent kinase inhibitor 1 A (CDKN 1A);           melanoma differentiation-associated protein 6           (MDA6); CDK-interacting protein 1 (dP1); WAF1;       541   SDI1   U09579; L25610   P38936           Janus tyrosine-protein kinase 3 (JAK3); leukocyte   P52333; Q13259;       542   janus kinase (LJAK)   U09607   Q13260; Q13611           45-kDa interleukin enhancer-binding factor 2 (ILF2);       543   45-kDa nuclear factor (NF45)   U10323   Q12905           epidermal growth factor receptor kinase substrate       549   EPS8   U12535   Q12929           caspase 2 (CASP2); neural precursor cell-           expressed developmentally down-regulated protein       550   2 (NEDD2); ICHi   U13021; U13022   P42575; P42576           CD151 antigen; platelet-endothelial cell tetraspan       558   antigen 3(PETA3); SEAl   U14650   P48509; Q14826       561   delta-like protein (DLK)   U15979; Z12172   P80370       567   DNA polymerase alpha catalytic subunit (POLA)   X06745   P09884       569   ski oncogene   X15218   P12755           neural cell adhesion molecule 1 (NOAMI); CD56           antigen: NCAM 140-kDa isoform (NCAM140) +       P13591; Q16180;           NCAM phosphatidylinositol-linked isoform; NOAM       Q15829 + P13592;       571   120-kDa isoform (NCAM120)   571824 + X16841   P13593       573   Wilms&#39; tumor protein (WT33; WT1)   X51630   P19544       575   120-kDa nucleolar protein 1 (NOLl; NOP120)   X55504   P46087       576   zinc finger X-chromosomal protein (ZFX)   X59738   P17010           thioredoxin peroxidase 2 (TDPX2); thioredoxin-           dependent peroxide reductase 2; proliferation-           associated gene (PAG); natural killer cell enhancing       582   factor A (NKEFA)   X67951   Q06830; P35703           macMARCKS; MAROKS-related protein (MRP);       583   MARCKS-like protein (MLP)   X70326   P49006           glutamate receptor 5 (GLUR5); lonotropic glutamate           receptor kainatel (GRIK1); excitatory amino acid       604   receptor 3 (EAA3)   L19058   P39086; Q13001       608   inhibinalpha(INHA)   M13981   P05111           beta 2 adrenergic receptor (ADRB2; ADRB2R;   P07550; Q14823;       610   B2AR)   M15169   Q13714           insulin-like growth factor-binding protein 3 (IGE-       615   binding protein 3; IGFBP3; IBP3)   M31159; M35878   P17936       620   cellular retinoic acid-binding protein II (CRABP2)   M68867   P29373           cell division cycle 25 homolog A (CDC25A); M-       633   phase inducer phosphatase 1 (MPh)   M81933   P30304       634   GuS-specific cyclin 03 (GCND3)   M92287   P30281           purine-rich element-binding protein A (PURA);           purine-rich single-stranded DNA-binding protein       635   alpha (PUR-alpha)   M96684   Q00577       637   DNA topoisomerase 1 (TOP 1)   J03250   P11387; Q9UJN0       638   DNA topoisomerase II alpha (TOP2A)   J04088   P11388           6-O-methylguanine-DNA methyltransferase           (MGMT); methylated-DNA-protein-cysteine       640   methyltransferase   M29971   P16455           xeroderma pigmentosum group D complementing           protein (XPD); X-ray repair-complementing           defective repair in Chinese hamster cells 2       642   (XRCC2)   X52221   P18074       644   rafi proto-oncogene   X03484   P04049       645   glutathione reductase (GSR)   X15722   P00390                   P00519; Q16133;       646   c-abl proto-oncogene   M14752   Q13869; Q13870           cyclin Dl (CCND 1); parathyroid adenomatosis       647   protein 1 (PRADI)   X59798   P24385           microsomal glutathione 5-transferase 1 (MGSTI);       648   GST12   J03746   P10620           excision repair cross-complementing rodent repair       649   deficiency complementation group 1 (ERC01)   M13194   P07992           glutathione S-transferase mul (GSTMI; GST1); HB       651   subunit 4; GTH4   X68676; S01719   P09488           glutathione S-transferase pi (GSTP1); GST3; fatty       652   acid ethyl ester synthase III (FAEES3)   X08058; M24485   P09211           glutathione S-transferase A1 (GTH1; GSTA1); HA       653   subunit 1; GST-epsilon   M25627   P08263; Q14750       654   cyclin D2 (CCND2)   M90813; 013639   P30279; Q13955           ras homolog gene family member A (RHOA;           ARHA); aplysia ras-related homolog 12 (ARH12;       657   RHOH12)   L25080   P06749       658   glutathione peroxidase 1 (GSHPX1; GPX1)   Y00483; M21304   P07203                   Z23115; L20121;       660   apoptosis regulator bcl-x   L20122   Q07817; Q92976       661   cytosohic superoxide dismutase 1 (5001)   K00065; X02317   P00441           mutL protein homologi (MLHI; hMLHI); colon       662   cancer nonpolyposis type 2 protein (COCA2)   U07418   P40692           UV excision repair protein RAD23 homolog B           (hHR23B); xeroderma pigmentosum group C           repair-complementing complex 58-kDa protein           (XPC repair-complementing complex 58-kDa       667   protein)   D21090   P54727           UV excision repair protein RAD23 homolog A       668   (RAD23A; hHR23A)   Q21235   P54725       670   cyclin H (CCNH); M015-associated protein   U11791; U12685   P51946       671   glutathione S-transferase theta 1 (GSTT1)   X79389   P30711; Q00226       675   integrin beta 5 (ITGB5)   J05633   P18084           integrin alpha E (ITGAE); 00103 antigen; mucosal       677   lymphocyte antigen 1 alpha (hMLI)   L25851   P38570           integrin beta 2 (ITGB2); cell surface adhesion           glycoproteins LFA-1/CR3/p150,95 beta subunit;           CD18 antigen; complement receptor 03 beta       679   subunit   M15395   P05107; Q16418           integrin beta 1 (ITGB1); fibronectin receptor beta           subunit (FNRB); very late antigen 4 beta subunit       688   (VLA4); CD29 antigen   X07979   P05556                   P23229; Q14646;       689   integrin alpha 6 (ITGA6); CD49F antigen; VLA6   X53586; X59512   Q16508; Q08443       692   integrin alpha 7B (IGA7B)   X74295   Q13683           40-kDa heat shock protein 1 (HSPFI); HSP40;       695   DNAJB1   Q49547   P25685       698   transcription factor Spi (TSFP1)   J03133   P08047       701   protein kinase C theta (PKC-theta)   L07032   Q04759           mitogen-activated protein kinase 8 (MAPK8;           PRKM8); c-jun N-terminal kinase 1 (JNKI); stress-   P45983; Q15709;       702   activated protein kinase gamma (SAPK-gamma)   L26318   Q15712; Q15713           cyclin-dependent kinase 4 inhibitor 2 (CDK4I;           CDKN2); p16-INK4; multiple tumor suppressor 1       703   (MTS1)   L27211   P42771; Q15191           mitogen-activated protein kinase p38 (MAP kinase           p38); cytokine suppressive anti-inflammatory drug-           binding protein (OSAID binding protein; CSBP);   Q16539; Q14084;       704   MAX-interacting protein 2 (MX12)   L35253; L35263   Q13083           mitogen-activated protein kinase kinase 3 (MAP           kinase kinase 3; MAPKK3; MAP2K3; PRKMK3);       705   MAPKIERK kinase 3 (MEK3)   L36719   P46734           mitogen-activated protein kinase kinase 4 (MAP           kinase kinase 4; MKK4; PRKMK4); c-jun N-terminal           kinase kinase 1 (JNKK1); JNK-activating kinase 1;       706   SAPKIERK kinase 1 (SERK1; SEK1)   L36870   P45985       708   N-myc proto-oncogene   M13228   P04198           retinoblastoma-associated protein 1 (RB1);       709   phosphoprotein 110 (ppl 10)   M15400   P06400; P78499       710   c-yes proto-oncogene; YESI   M15990   P07947       714   G2/mitotic-specific cyclin Bi (CONBI)   M25753   P14635       715   protein kinase C beta 1 (PRKCB1)   X06318   P05771           cAMP-dependent protein kinase type II beta       716   regulatory subunit (PRKAR2B; PKR2)   M31158   P31323           heat shock 60-kDa protein (HSP60); HSPDI; 60-           kDa chaperonin; mitochondrial matrix protein P1;       717   p60 lymphocyte protein; HUCHA60; GroEL protein   M34664   P10809       719   growth arrest &amp; DNA damage-inducible protein   M60974   P24522           (GADD45); DNA damage-inducible transcript 1           (DDIT1)           cAMP-dependent protein kinase type 1 beta       721   regulatory subunit (PRKAR1B)   M65066   P31321                   P24864; Q14091;       723   G1/S-specific cyclin E (CONE)   M73812   Q92501                   P25054; Q15162;       724   adenomatous polyposis coli protein (APO); DP2.5   M74088; M73548   Q15163           mitogen-activated protein kinase 1 (MAP kinase 1;           MAPK1; PRKM 1); extracellular signal-regulated       727   kinase 2 (ERK2)   M84489   P28482       730   Sp2 protein   M97190   Q02086       731   Sp3 protein   M97191   Q02447           growth arrest &amp; DNA damage-inducible protein 153           (GADDIS3); DNA damage-inducible transcript 3       732   (DDIT3); C/EBP homologous protein (CHOP)   S40706; S62138   P35638           receptor (TNFRSF)-interacting serine-threonine       741   kinase 1 (RIPKI); receptor-1nteracting protein (RIP) U25994; U50062   Q13546; Q13180           DNA-activated protein kinase catalytic polypeptide           (PRKDC); DNA-dependent protein kinase 1           (DNAPK1); hyper-radiosensitivity of murine SCID           mutation complementing protein 1 (HYRC1);   Q13337; P78527;       745   XRCC7   U35835; U47077   Q14175           cyclin-dependent kinase 4 inhibitor 2D (CDKN2D);       746   p19-INK4D   U40343; U20498   P55273; Q13102       748   breast cancer type 2 susceptibility protein (BROA2)   U43746   P51587       749   G2/mitotic-specific cyclin G1 (CCNG1; CYOGI)   U47413   P51959       753   cyclin A1 (CONA1)   U66838   P78396           90-kDa heat-shock protein A (HSP90A); HSP86;       755   HSPCA   X07270   P07900           cAMP-dependent catalytic protein kinase alpha       756   (PRKAC-alpha; PRKACA)   X07767   P17612           fos-related antigen 2 (FRA2); fos-like antigen 2       758   (FOSL2)   X16706   P15408       760   ezrin; cytovillin 2; villin 2 (VIL2)   X51521   P15311; P23714           27-kDa heat shock protein (HSP27); stress-           responsive protein 27 (SRP27); estrogen-regulated       761   24-kDa protein; HSPB1   X54079   P04792       764   junD proto-oricogene   X56681   P17535       765   c-src kinase (CSK); protein-tyrosine kinase cyl   X59932   P41240           mitogen-activated protein kinase 3 (MAP kinase 3;           MAPK3; PRKM3); extracellular signal-regulated       766   kinase 1 (ERKI); ERT2   X60188   P27361                   X56134; M14144;       767   vimentin (VIM)   Z19554   P08670           mitogen-activated protein kinase 6 (MAP kinase 6;           MAPK6; PRKM6); p97-MAPK; extracellular signal-       769   regulated kinase 3 (ERK3)   X80692   Q16659       770   fas-activated serine/threonine kinase (FAST)   X86779   Q14296           beta 1 catenin (CTNNB); cadherin-associated       771   protein   X87838; Z19054   P35222           menage a trois 1 protein (MNAT1; MAT1); CDK-           activating kinase assembly factor (OAK assembly       773   factor); CDK7/cyclin H assembly factor   X92669   P51948           mitogen-activated protein kinase 9 (MAP kinase 9;   P45984; Q15708;       779   MAPK9; PRKM9); c-jun N-terminal kinase 2 (JNK2) L31951   015710; 015711       780   protein-tyrosine phosphatase 1 E   L34583   Q15674           caspase 1 (CASP1); IL1-beta convertase (IL1BC); U13699; M87507;       783   IL1-beta-converting enzyme (ICE)   X65019   P29466           BCL2/adenovirus E1B 19-koa-interacting protein 3       786   (BNIP3; NIP3)   U15174   Q12983; 014620       787   caspase 6 (CASP6); MCH2-alpha; MCH2-beta   U20536; U20537   P55212               U23765; U16811;       788   BCL2 homologous antagonist/killer 1 (BAK1)   X8421 3   016611; 092533           caspase 4 (GASP4); GASPS; ICH2 cysteine           protease; ICH3; TX protease; TY protease;       789   ICE(REL) III   U28014; U28015   P49662; P51878           mitogen-activated protein kinase 10 (MAP kinase           10; MAPK10; PRKM10); MAP kinase p493F12; c-       791   jun N-terminal kinase 3 alpha 2 (JNK3A2)   U34819; U07620   P53779; Q15707           caspase 7 (CASP7); MCH3; ICE-like apoptotic       792   protease 3 (ICE-LAP3); GMH-1   U37448   P55210; 013364           inhibitor of apoptosis proteini (HIAP1; API1) + IAP           homolog C; TNFR2-TRAF signaling complex       793   protein 1; MIHO   U45878 + U37546   Q13489; Q16628           inhibitor of apoptosis protein 2 (hIAP2; IAP2); IAP           homolog B; TNFR2-TRAF signaling complex       794   protein 2; MIHC   U45879; U37547   Q13490; Q16516           inhibitor of apoptosis protein 3 (API3; IAP3); X-           linked inhibitor of apotosis protein (X-linked IAP;       795   XIAP); IAP-like protein (HILP)   U45880; U32974   P98170           caspase 10 (CASP10); MCH4; ICE-like apoptotic       799   protease 4 (ICE-LAP4); FADO-like ICE 2 (FLICE2)   U60519   Q92851; Q99845           caspase 8 (CASP8); MORTI -associated CED3           homolog (MACH); FADO-homologous IGE/CED-3-   U60520; U58143;   Q14790; Q15780;       800   like protease (FADO-like ICE; FLICE); MCH5   X98172   Q15806       801   interferon regulatory factor 1 (IRF1)   X14454   P10914       802   FAN protein   X96586   Q92636       808   zinc-finger DNA-binding protein   Q45132   Q13029           5-hydroxytryptamine receptor 3A receptor (HTR3A);       809   serotonin receptor   D49394   P46098       812   CDC-like kinase 2 (CLK2)   L29216   P49760       813   CDC-like kinase 3 (CLK3)   L29220   P49761       814   CDC-like kinase 1 (GLK1)   L29222   P49759       817   heat shock 70-kDa protein 1 (HSP70.1; HSPA1)   M11717   P08107; P19790       819   insulin-like growth factor 1 (IGF1); somatomedin C   M27544; M37484   P01343; 014620           protein C inhibitor (PROd; PCI); plasma serine           protease inhibitor; plasminogen activator inhibitor 3       822   (PLANH3; PAI3)   M68516; J02639   P05154           wee1Hu 00K tyrosine 15-kinase; wee-I-like protein       829   kinase   U10564   P30291           DNA damage repair &amp; recombination protein 52       830   homolog (RAD52)   U12134   P43351; Q13205       834   3′5′-cAMP phosphodiesterase HPDE4A6   U18087   P27815       835   CD40 receptor-associated factor 1 (CRAF1)   U21092   Q13114       838   CBL-B   U26710   Q13191           90-kDs TATA box-binding protein-associated factor           RNA polymerase III C (TAF3C); transcription factor       840   TFIIIB 90-kDa subunit (TFIIIB90)   U28838   Q13223           transcription initiation factor lID 31-kDa subunit           (TFIID); TATA-box-binding protein-associated factor           RNA polymerase II G 32-kDa subunit (TAFII32;       841   TAF2G); TAFII31   U30504   Q16594           cytoplasmic dynein light chain 1 (hDLC1; DLC1);           protein inhibitor of neuronal nitric oxide synthase       843   (PIN)   U32944   Q15701       845   ataxia telangiectasia mutated protein (ATM)   U33841   Q13315           erythrocyte urea transporter (UTE; UT1); solute           carrier family 14 member 1 (SLC14A1); HUT11;       846   RACH1   U35735   Q13336           mitogen-activated protein kinase kinase 6 (MAP           kinase kinase 6; MAPKK6; MAP2K6; PRKMK6);       849   MAPK/ERK kinase 6 (MEK6); SAPKK3   U39657   P52564       851   C-1 protein; prefoldin 4 (PFDN4; PFD4)   U41816   Q92779           ubiquitin-conjugating enzyme E21 (UBE21); UBC9       855   homolog   U45328   P50550; Q15698           mothers against decapentaplegic homolog 1           (MADHI; SMAD1); TGF-beta signaling protein 1       859   (BSP1)   U57456   Q15797       860   BCL2-like 2 (BCL2L2); BCL-W; K1AA0271   U59747   Q92843       863   neogenin   U61262   Q92859           DNA damage repair &amp; recombination protein 50       864   homolog (RAD50)   U63139   Q92878           cytoplasmic antiproteinase 3 (CAP3); protease       867   inhibitor 19 (P19)   U71364   P50453           DNA ligase IV (LIG4); polydeoxyribonucleotide       869   synthase   X83441   P49917           DNA ligase III (LIG3); polydeoxyribonucleotide       870   synthase   X84740   P49916           deoxyribonuclease I-like protein 1 (DNase1L1;   X90392; L40817;       871   DNL1L); DNase X   U06846   P49184           cyclin-dependent kinase inhibitor 3 (CDKN3);           CDK2-associated dual-specificity phosphatase;           kinase-associated phosphatase (KAP); cyclin-       876   dependent kinase interacting protein 2 (CIP2);   L25876   Q16667; Q99585           cyclin-dependent kinase interactor 1 (CDI1)           Y chromosome variable charge protein (VOY);           testis-specific basic protein on Y chromosome 1       AH002   (BPY1)   AF000979   O14598       AH019   RAN-binding protein 1 (RANBP1)   D38076   P43487           ubiquitin protein ligase E3A (UBE3A); papilloma       AH038   virus E6-associated protein (EPVE6AP; E6AP)   L07557   Q05086; Q93066           phosphodiesterase 7A (PDE7A); high-affinity           cAMP-specific 3,5′-cyclic phosphodiesterase       AH041   (HCP1)   L12052   Q13946; O15380       AH047   skeletal muscle troponin 1 fast twitch 2 (TNN12)   L21 715   P48788       AH051   ADP-ribosylation factor-like 1 (ARL1)   L28997   P40616; P80417       AH054   type 1 inositol 1,4,5-triphosphate receptor (ITPR1) L3801 9   Q14660           ADP-ribosylation factor 4-like protein (ARF4L);       AH055   ADP-ribosylation factor-like 6 protein (ARL6)   L38490   P49703       AH061   angiogenin (ANG); RNaseAfamily5 (RNase5)   M11567   P03950       AH063   lamin C   M13451   P02546       AH064   related ras oncogene homolog (RRAS)   M14949   P10301           protein phosphatase 3 catalytic subunit alpha       AH070   (PPP3CA); PPP2B; calcineurin A alpha (CALNA)   M29550   Q08209           nuclear receptor subfamily 2 group C member 1       AH071   (NR2C1); TR2 nuclear hormone receptor; TR2-11   M29960   Q15625           dolichyl-phosphate mannosyltransferase           polypeptide 2 regulatory subunit (DPM2); dolichol       AH0735   phosphate-mannose synthesis protein 2   AB013361   094777       AH0774   homolog of shkl kinase-binding protein 1 (SKB1)   AF015913   Q14744       AH07B   ADP ribosylation factor 4 (ARF4)   M36341   P18085; P21371       AH079   histone 2AZ (H2AZ)   M37583   P17317           PTPRF-interacting protein-binding protein 2       AH0809   (PPFIBP2); liprin beta 2   AF034803   Q75337           SH3 domain-binding glutamic acid-rich-like protein       AH0825   (SH3BGRL)   AF042081   Q75368           Y-encoded testis-specific-like protein (TSPY-like       AH0827   protein; TSPYL)   AF042181   Q75885           palmitoylated membrane protein 1 (MPP1);           erythrocyte membrane protein 55 (EMP55);           palmitoylated erythrocyte membrane protein       AH086   (PEMP)   M64925   Q00013           voltage-dependent calcium channel alpha 2/delta           subunit 1 (CACNA2D1); malignant hyperthermia       AH090   susceptibility protein 3 (MHS3)   M76559   P54289       AH0900   SYT-interacting protein (SIP)   AF080561   Q75932       AH0906   heat shock 40-kDa protein 3 (HSP40-3)   AF088982   Q75953           solute carrier family 7 member 7 (SLC7A7); y + L-       AH0939   type amino acid transporter 1 (Y + LAT1)   AJ130718   Q95984       AH094   skeletal muscle actinin alpha 3 (ACTN3)   M86407   Q08043       AH0944   C4.4-like protein   AJ223603   none           nucleosome assembly protein 1-like 1 (NAPI-       AH095   related protein) M86667 P55209           osteoblast-specific factor 2 (OSF2); fasciclin I-like       AH0951   protein   D13665   Q15063; Q15064           U2 small nuclear ribonucleoprotein auxiliary factor       AH0962   small subunit 1 (U2AFIRS1)   D49676   Q15695; Q13570       AH0965   transducer of erbB2 2 (TROB2; TOB2); TOB4   D64109   Q14106       AH097   lamin B2 (LMNB2)   M94363   Q14734           germline microsatellite sequence (human brain       AH0998   cDNA library)   L35592   none       AH1001   asialoglycoprotein receptor 1 (ASGR1)   M10058   P07306       AH1002   cellular retinol-binding protein 1 (RBP1; CRBP1)   M11433   P09455       AH102   nuclear autoantigenic sperm protein (NASP)   M97856   P49321       AH1038   POM121 homolog &amp; ZP3 fusion protein (POMZP3)   U10099   Q12903       AH1059   zeste-white 10 homolog (ZW10; hZW10)   U54996   Q43264           solute carrier family 12 member 4 (SLC12A4);       AH1060   potassium-chloride cotransporter 1 (KCC1)   U55054   Q13953       AH110   alpha 1 syntrophin   S81737   Q16438           growth hormone receptor (GH receptor; GHR);       AH1112   serum-binding protein   X06562   P10912           60S ribosomal protein L3 (RPL3); HIV-1 TAR RNA-       AH1123   binding protein B (TARBP-B)   X73460   P39023; Q15548       AH1132   sperm mitochondrial capsule selenoprotein (MCS)   X89960   P49901       AH1146   kinesin-like protein 2 (KIF2)   Y08319   O00139       AH1187   BAI1-associated protein 1   AB010894   Q75085       AH1193   protein kinase   AB015718   Q94804       AH1215   RAD51-interacting protein (PIR51)   AF006259   Q43403       AH1223   DNAJ protein   AF012106   Q14716       AH1248   alpha 1,2-mannosidase IB   AF027156   Q60476       AH1254   timing protein CLK-1   AF032900   none           NADH dehydrogenase (ubiquinone) 1 alpha           subcomplex 2 (NDUFA2); NADH-ubiquinone       AH1272   oxidoreductase B8 subunit   AF047185   Q43678           retinal short-chain dehydrogenase/reductase 1       AH1292   (RETSDR1)   AF061741   Q75911       AH1295   KEOS protein   AF064605   Q60737       AH1303   heat shock factor-binding protein 1 (HSBP1)   AF068754   Q75506       AH131   deleted in azoospermia protein (DAZ); SPGY   U21663   Q13117       AH1318   sperm-associated antigen 6 (SPAG6); REPROSA1   AF079363   Q75602       AH1327   HOMER3   AF093265   Q95350           glucocerebrosidase pseudogene [alternatively       AH1355   spliced]   D13287   none       AH1359   estrogen-responsive finger protein (EFP)   D21205   Q14258       AH1381   intestinal trefoil factor 3 (TFF3; ITF; hITF)   L08044   Q07654       AH1385   amino acid transport-related protein   L11696   Q15295       AH140   membrane copper amine oxidase; vascular   U39447   Q16853           adhesion protein 1 (VAP1); HPAO           glutamine-fructose-6-phosphate transaminase 1       AH1416   (GFPT1; GFAT)   M90516   Q06210       AH1436   ki nuclear autoantigen   U11292   Q12920           centromere protein A (CENPA); centromere       AH1438   autoantigen A   U14518   P49450           cytosolic brainched-chain amino acid       AH1443   aminotransferase (BCAT); ECA39 protein   U21551   P54687       AH148   SMOY   U52191   Q92809           HS1-binding protein; HSI -associated protein X-1       AH1482   (HAX1)   U68566   O00165           erythrocyte membrane protein band 7.2 (EPB72);       P27105; Q14087;       AH1535   stomatin   X60067   Q15609           DiGeorge syndrome critical region 6 protein       AH1552   (DGCR6)   X96484   Q14129           nucleosome assembly protein 1-like 4; nucleosome       AH161   assembly protein 2 (NAP2)   U77456   Q99733       AH168   histone 2AX (H2AX)   X14850   P16104           alpha centractin; centrosome-associated actin       AH184   homolog; actin-RPV 1 (ARP1)   X82206   P42024           rev-interacting protein (RIP); rev/rex activation       AH190   domain-binding protein   X89478   P52594; Q15277           acid lysosomal sphingomyelin phosphodiesterase 1       AH2014   (SMPD1); acid sphingomyelinase   X59960   P17405; P17406                   Q92572; O00721;                   O00647; O00727;       AH215   clathrin coat assembly protein-like protein   D63643   Q00676           DNA-directed RNA polymerase II 33-kDa       AH225   polypeptide (RPB33)   J05448   P19387; Q15161       AH228   RD protein   L03411   P18615       AH234   carbonic anhydrase IV; carbonate dehyratase IV   M83670   P22748           serine-rich domain RNA-binding protein SI       AH245   (RNPS1)   L37368   Q15288       AH252   U2 small nuclear ribonucleoprotein B   M15841   P08579       AH254   alpha-2-HS-glycoprotein; fetuin; alpha-2-Z-globulin   M16961   P02765; Q14962       AH267   fibrillarin; 34-kDa nucleolar scleroderm antigen   M59849   P22087       AH283   fibrillin 2   U03272   P35556           thioredoxin peroxidase A0372; thioredoxin-           dependent peroxide reductase A0372; antioxidant       AH296   enzyme 372 (A0E372)   U25182   Q13162       AH298   RNA-binding motif protein 3 (RBM3); IS1-RNPL   U28686   P98179       AH306   C-terminal-binding protein 1   U37408   Q13363           postmeiotic segregation increased homolog 2-like       AH310   protein 1 (PMS2L1); PMS3   D38499   Q16530       AH311   beta2-syntrophin   U40572   Q13425       AH332   Ul small nuclear ribonucleoproteinG (U1C)   X12517   P09234           lupus LA ribonucleoprotein; Sjogren syndrome type       AH334   B antigen (SSB)   X13697   P05455           heterogeneous nuclear ribonucleoprotein L       AH336   (HNRNPL)   X16135   P14866           complement factor B; 03/CS convertase; properdin           factor B; glycine-rich beta glycoprotein (GBG);       P00751; O15006;       AH348   PBF2 X72875 Q29944       AH352   poly(C)-binding protein 2; HNRNP-E2   X78136   Q15366           polyadenylate-binding protein 1 (poly(A)-binding       AH365   protein 1; PABP1)   Y00345   P11940; Q93004           proteasome epsilon subunit; proteasome subunit X;           proteasome subunit 6; proteasome subunit MBI;           PSMB5; macropain epsilon subunit; multicatalytic       AH391   endopeptidase complex epsilon subunit; LMPX   D29011   P28074; Q16242       AH398   proteasome subunit Z   D38048   Q99436       AH405   transcription elongation factor S-II (hSIIT1)   D50495   Q15560       AH410   605 ribosomal protein L39 (RPL39)   D79205   P02404; P39025           folate receptor beta (FR-beta); fetal/placental folate       AH416   receptor; placental folate-binding protein (FBP)   J02876   P14207           liver/heart cytochrome c oxidase polypeptide VIII       AH421   (GOX8)   J04823   P10176; P15955           argininosuccinate synthase; citrulline-aspartate       AH423   ligase   X01630   P00966       AH424   glutathione 5-transferase mu 5 (GSTM5-5)   L02321   P46439       AH425   26S protease regulatory subunit (P2654)   L02426   Q03527           alpha-synuclein; non-A beta component of AD       AH433   amyloid (NACP)   L08850   P37840; Q13701       AH436   605 ribosomal protein L7 (RPL7)   L16558   P18124           protein-lysine oxidase homolog; lysyl oxidase       AH440   homolog; lysyl oxidase-like protein   L21186   Q08397       AH462   405 ribosomal protein 517 (RPSI7)   M13932   P08708       AH464   uroporphyrinogen decarboxylase (UROD)   M14016   P06132; Q16883           glutamine-hydrolyzing asparagine synthetase; TS11       AH480   cell cycle control protein   M27396   P08243; P08184           peptidyl-glycine alpha-amidating monooxygenase       AH487   (PAM)   M37721   P19021           tripeptidyl peptidase II (TPP I1); tripeptidyl       AH488   aminopeptidase   M55169   P29144           trans-activation-responsive RNA-binding protein       AH490   (TAR RNA-binding protein)   M60801   Q15633; Q12878           peptidyiprolyl cis-trans isomerase B (PPIase; PPIB);           rotamase; cyclophilin B (CYPB); 5-cyclophilirt       AH491   (SCYLP)   M60857   P23284       AH511   605 ribosomal protein L24 (RPL24)   M94314   P38663       AH513   lysyl hydroxylase   M98252   none       AH515   transglutaminase   M98479   none       AH523   26S proteasome subunit S5B; KIAA0072; HA1357   S79862   Q16401; Q15045       AH539   zinc finger protein 143; SPH-binding factor   U09850   P52747; O75559           histidyl-tRNA synthetase homolog (HISRS);       AH552   histidine-tRNA ligase homolog   U18937   P49590       AH582   transcription initiation protein SPT4 homolog 1   U43923   Q16550; Q62387       AH590   signal recognition particle 54-kDa protein (SRP54)   U51920   P13624           signal recognition particle receptor alpha subunit       AH607   (SR-alpha); docking protein alpha (DP-alpha)   X06272   P08240           liver cytochrome c oxidase polypeptide VIa       AH614   (GOX6A)   X15341   P12074; 043714           mitochondrial bifunctional           methylenetetrahydrofolate       AH618   dehydrogenase/cyclohydrolase   X16396   P13995       AH619   cytochrome c oxidase polypeptide Vllc (COX7C)   X16560   P15954           mitochondrial erythroid-specific 5-aminolevulinic           acid synthase (ALAS-E); delta-aminolevulinate       AH630   synthase (delta-ALA synthetase) X56352   P22557       AH632   mitochondrial ATP synthase B chain   X60221   P24539           elongation factor 1 alpha 2 (EF1-alpha 2; EF1A2);       AH650   statin S1   X70940   Q05639; P54266       AH653   trypsinogen IV B form   X71345   Q15665           18-kDa ubiquitin-conjugating enzyme E2; UBCH7;           ubiquitin-protein ligase; ubiquitin carrier protein;       AH683   UBCM4   X92962   P51966           dolichyl-diphosphooligosaccharide-protein       AH690   glycosyltransferase 63-kDa subunit; ribophorin II   Y00282   P04844       AH692   glutamine synthetase; glutamate-ammonia ligase   Y00387   P15104       AH698   selenoprotein P   Z11793   P49908           annexin II (ANX2); lipocortin II; calpactin 1 heavy           subunit; chromobindin 8; protein I; placental       B1   anticoagulant protein IV (PAPIV)   D00017   P07355           retinoic acid-induced gene E (RIGE); lymphocyte           antigen 6 complex locus E (LY6E); thymic shared       B105   antigen 1 (TSA1); stem cell antigen 2 (SCA2)   U42376   Q16553           interferon regulatory factor 5 (IRF-5) DNA-binding       B110   nuclear protein   U51127   Q13568           macrophage inflammatory protein 3 beta (MIP3-   Q99731 Q00736       B117   beta; MIP3B); EBII ligand chemokine (ELO)   U77180   Q00697       B120   CX3C chemokine   U91835   P78423 Q00672           homeobox protein D4 (HOXD4); HOX4.2; H0X5.1;       B128   HHO C13   X04706; X17360   P09016       B133   CD37 antigen   X14046   P11049           intercellular adhesion molecule 2 (ICAM2); CD102       B134   antigen   X15606   P13598       B135   interferon regulatory factor 2 (IRF2)   X15949   P14316       B146   T-cell differentiation 006 antigen; TP12   X60992   P30203       B149   leukemia inhibitory factor receptor (LIFR)   X61615   P42702           T cell receptor beta locus (TRB@); T-cell antigen       B150   receptor beta polypeptide (TCRB; TRB)   X63456   none           myosin heavy chain smooth muscle isoform       B160   (SMMHC); MYH11   X69292   O00396; P35749       B185   natural resistance-associated macrophage protein 2   L37347   P49281           (NRAMP2)       B200   T-cell surface glycoprotein CD1D; R3G1   J04142   P15813           pre-B-cell leukemia transcription factor-I;       B201   homeobox protein pbxl; Homeobox protein prl M86546   P40424           pre-B-cell leukemia transcription factor-2;       B202   homeobox protein PBX2   X59842   P40425       B207   nucleolysin TIA-1   M77142   P31483           small inducible cytokine subfamily A member 11   D49372; Z75669;   P51671; P50877;       B211   (SCYA11); CC chemokine eotaxin   Z75668   Q92490; Q92491       B218   homeobox protein A4 (HOXA4); HOXiD; HOXI.4   M74297   Q00056           stathmin; phosphoprotein p19 (PP19); oncoprotein           18 (OP18); leukemia-associated phosphoprotein       B23   p18 (LAP18); prosolin; metablastin   J04991   P16949       B239   homeobox protein A5 (HOXAS); HOXiC   M26679   P20719                   P17813; Q14248;       B24   endoglin (ENG; END); OD10S antigen   J05481; X72012   Q14926           homeobox protein B6 (HOXB6); HOX2B; HOX2.2;   X58431; M30597;       B246   HU-2   K02571   P17509           sex-determining region Y box-containing gene 4       B247   (SRY box-containing gene 4; SOX4)   X70683; X65661   Q06945       B250   thy-1 membrane glycoprotein; CDW90 antigen   M11749   P04216       B34   AF-4 protein; fel protein   L13773   P51825       B42   tyrosine-protein kinase syk; spleen tyrosine kinase   L28824   P43405       B53   myeloperoxidase (MPO)   M19507   P05164                   P06748; P08693;           nucleophosmin 1 (NPM1); nucteolar       Q12826; Q14115;       B56   phosphoprotein B23; numatrin   M23613   Q13440; Q13441           perform 1 (P1); lymphocyte pore forming protein       B63   (PFP); cytolysin; PREI   M28393   P14222           complement decay-accelerating factor (OAF); CD55       B64   antigen   M31516   P08174       B65   B-cell lymphoma 3 protein (BCL3)   M31732   P20749           CD81 antigen; 26-kDa target of antiproliferative       B68   antibody 1 (TAPA1)   M33680   P18582           leukocyte surface CD53 antigen; cell surface       B69   glycoprotein 0053; M0X44   M37033   P19397           interleukin 3 receptor beta subunit (IL3R-beta;           IL3RB); interleukin 5 receptor beta subunit (IL5R-           beta; IL5R); cytokine receptor common beta chain;       B74   CSF2RB   M59941   P32927           B-cell antigen receptor complex associated protein           alpha-chain DE; Ig-alpha (IGA); MB-1 membrane           glycoprotein; surface-IgM-associated protein;           membrane-bound immunoglobulin associated       B78   protein; CD79A antigen   M74721   P11912       B81   CD14 antigen   M86511   P08571       B83   ferritin heavy polypeptide 1 (FTH1); FTHL6   M97164   P02794       B85   B-cell lymphoma 6 protein (BCL6); zinc finger   U00115   P41182           protein 51 (ZNF51); LAZ3 protein       B92   AF1q   U16954   Q13015           lymphotactin (LTN); cytokine scm-i alpha;       B97   lymphotaxin; small inducible cytokine Cl (SCYC1)   U23772   P47992                   Q16363; Q15335;       C100   laminin alpha 4 subunit (laminin A4; LAMA4)   X70904; X91171   Q14735           chromatin assembly factor 1 p48 subunit (CAF1           p48 subunit); retinoblastoma-binding protein 4       C101   (RBBP4); RBAP48; msil protein homolog   X74262   Q09028; P31149       C116   ras-like small GTPase TTF   Z35227   Q15669       C126   NEDD5 protein homolog; DIFF6; KIAA0158   D63878   Q15019; Q14132           serine/threonine-protein kinase receptor R3           (SKR3); activin receptor-like kinase 1 (ACVRL1;           ALK1); TGF-beta superfamily receptor type 1       C13   (TSR1)   L17075   P37023       C130   collagen X1alpha 1 subunit(COLI1A1)   J04177   P12107           bone/cartilage small proteoglycan 1 (PGS 1);       C131   biglycan (BGN)   J04599   P21810; P13247           E2F dimerization partner 1 (TFDP1); DRTF1       C138   polypeptide 1 (DP1)   L23959   Q14186       C14   glial cell line-derived neurotropic factor (GDNF)   L19063   P39905       C152   cell division cycle 25 homolog C (CDC25C)   M34065   P30307           CDC42 homolog; G25K GTP-binding protein (brain       C154   isoform + placental isoform)   M35543 + M57298   P21181 + P25763           insulin-like growth factor binding protein 5 (IGF-       C159   binding protein 5; IGFBP5)   M65062   P24593           neurogenic locus notch protein homolog 1           (NOTCH 1); translocation-associated notch protein       C160   (TAN1)   M73980   P46531           cadherin-associated protein-related protein (CAPR);       C162   alpha 2 catenin (CTNNA2); alpha N catenin   M94151   P26232       C163   B-raf proto-oncogene (RAFB1)   M95712   P15056       C17   collagen XVIII alpha 1 subunit (COL18A1)   L22548   P39060       C170   p21-activated kinase alpha (PAK-alpha; PAK1)   U24152   Q13153; Q13567           p21-activated kinase gamma (PAK-gamma; PAK2);       C171   PAK65; S6/H4 kinase   U24153   Q13177; Q13154           mitogen-activated protein kinase 7 (MAP kinase 7;           MAPK7; PRKM7); extracellular signal-regulated       C172   kinase 5 (ERKS); BMK1 kinase   U25278   Q13164; Q16634                   P13942; Q13273;       C173   collagen X1alpha 2 subunit (COLl 1A2)   U32169   Q07751           mitogen-activated protein kinase P38 beta (MAP           kinase P38 beta); stress-activated protein kinase 2       C179   (SAPK2)   U53442   Q15759; Q00284           FKBP-rapamycin associated protein (FRAP);       C18   rapamycin target protein   L34075   P42345           cell division control protein 2 homolog (CDC2); p34       C183   protein kinase; cyclin-dependent kinase 1 (CDK1)   X05360   P06493       C185   collagen IV alpha 2 subunit (COL4A2)   X05610   P08572           low-density lipoprotein receptor-related protein 1           (LRP); alpha-2-macroglobulin receptor (A2MR);       C187   apolipoprotein E receptor (APOER); CD91 antigen   X13916   Q07954       C188   collagen III alpha 1 subunit (COL3A1)   X14420   P02461       C190   procollagen II alpha 1 subunit (COL2A1)   X16468   P02458       C191   collagen IX alpha 1 subunit (COL9A1)   X54412   P20849           mitogen-activated protein kinase 4 (MAP kinase 4;       C195   MAPK4; PRKM4); ERK3-related protein   X59727   P31152           cadherin 3 (CDH3); placental cadherin (P-cadherin;       C197   CDHP)   X63629   P22223           serine/threonine-protein kinase PCTAIRE 3       C199   (PCTK3)   X66362   007002           serine/threonine-protein kinase POTAIRE 1       C200   (PCTK1)   X66363   Q00536           retinoblastoma-like protein 2 (RBL2; RB2); 130-kDa       C204   retinoblastoma-associated protein   X74594   Q08999           tenascin (TN); hexabrachion (HXB); cytotactin;           neuronectin; GMEM; miotendinous antigen; glioma-       P24821; Q15567;       C206   associated extracellular matrix antigen   X78565; M55618   Q14583           mitogen-activated protein kinase 12 (MAP kinase           12; MAPK12; PRKM12); MAP kinase p38 gamma;           stress-activated protein kinase 3 (SAPK3);       C207   extracellular signal-regulated kinase 6 (ERK6)   X79483   P53778           cyclin-dependent kinase 5 activator (CDKS           activator); tau protein kinase II 23-kDa subunit;       C209   TPKII regulatory subunit   X80343   Q15078       C21   alpha-2-macroglobulin (alpha-2-M)   M11313   P01023           cadherini (CDH 1); epithelial cadherin (E-cadherin;       C215   CDHE); uvomorulin (UVO); CAM 120/80   Z13009   P12830; Q14216                   Q13752; Q14941;       C216   laminin gamma 2 subunit (LAMC2)   Z15009   Q02536       C22   proliferating cyclic nuclear antigen (PCNA); cyclin   M15796; J04718   P12004           wingless-related MMTV integration site 13 protein       C220   (WNT1 3)   Z71621   Q93097; 14903       C221   myeloid cell leukemia protein 1 (MCL1)   L08246   Q07820       C222   PDCD2   S78085   Q16342       C234   DAXX   AF015956   O14747       C238   hyaluronan receptor (RHAMM)   U29343   O75330           platelet glycoprotein IV (GPIV; PAS IV; PAS4);       C24   GPIIIB; CD36 antigen   M24795   P16671           BCL2 antagonist of cell death (BAD); BCL2L8;       C240   BCL2-binding component 6 (BBC6) U66879   Q92934           mitogen-activated protein kinase kinase kinase 3           (MAPKKK3;.MAP3K3); MAPK/ERK kinase kinase 3       C250   (MEK kinase 3; MEKK3)   U78876   Q99759       C254   smoothened homolog (SMOH)   U84401   Q99835       C257   neurogenic locus notch protein homolog 4   U95299   O00306           (NOTCH4)           BCL2-binding athanogene 1 (BAG1); glucocorticoid       Q99933; Q14414;       C259   receptor-associated protein RAP46   583171; Z35491   O75315       C265   NIK serine/threonine protein kinase   Y10256   Q99558       C27   nidogen (NID); entactin   M30269   P14543; Q14942       C274   manic fringe homolog (MFNG)   U94352   000587       C277   c-fos proto-oncogene; G0S7 protein   K00650   P01100       C282   plasminogen (PLG)   X05199   P00747           mitogen-activated protein kinase kinase 2 (MAP           kinase kinase 2; MAPKK2; MAP2K2; PRKMK2);       C286   MAPKIERK kinase 2 (MEK2)   L11285   P36507       C287   Indian hedgehog (IHH)   L38517   Q14623                   M24857; M38258;       C290   retinoic acid receptor gamma (RARG)   M57707; M32074   P13631       C292   v-Ki-RAS2B proto-oncogene (KRAS2)   M54968   P01118           akt1 proto-oncogene; rac alpha serine/threonine       C296   kinase (RAC-PK-alpha); protein kinase B (PKB)   M63167   P31749           rac-beta serinelthreonine kinase (rac-PK-beta);       C297   AKT2   M77198; M95936   P31751           casper, a FADD- and caspase-related inducer of           apoptosis (CASH-alpha + CASH-beta); FLAME-1;   AF010127;       C304   FLICE-like inhibitory protein   Y14039; Y14040   O15519           ras-related C3 botulinum toxin substrate 1 (RAC1);       C309   ras-likeprotein TC25   M29870; M31467   P15154           PRB-binding protein E2F1; retinoblastoma-binding           protein 3 (RBBP3); retinoblastoma-associated       Q01094; Q92768;       C313   protein 1 (RBAP1); PBR3   M96577   Q13143               U91903; U24163;   O00181; Q92765;       C314   frizzled-related FrzB (FRITZ); frezzled (FRE)   U68057   Q99686           mitogen-activated protein kinase kinase 5 (MAP           kinase kinase 5; MAPKK5; MAP2KS; PRKMK5);       C315   MAPKIERK kinase 5 (MEKS)   U25265   Q13163           caspase &amp; RIP adaptor with death domain           (CRADD); RIP-associated protein with death       C318   domain (RAIDD)   U84388   P78560           CD59 glycoprotein; membrane attack complex           inhibition factor (MACIF); MAC inhibitory protein           (MACIP); MEM43 antigen; protectin; membrane           inhibitor of reactive lysis (MIRL); HRF20; IFS       C32   antigen   M34671   P13987       C34   CD9 antigen; leukocyte antigen MIC3   M38690   P21926       C349   apoptosis-related protein TFARI5   AF022385   Q14811           signal transducer and activator of transcription 1           alpha/beta (STAT1); transcription factor ISGF-3       C354   components p91/p84   M97935   P42224           metalloprotease/disintegrin/cysteine-rich protein       C358   (MDC9)   U41766   Q13443       C365   seven in absentia homolog   U63295   Q43269           glutathione-S-transferase-like protein (GSTTLp28);       C370   glutathione transferase omega (GST01)   U90313   P78417           Bruton+S tyrosine kinase (BTK);           agammaglobulinaemia tyrosine kinase (ATK); B-cell       C372   progenitor kinase (BPK)   U10087; X58957   Q06187           ephrin type-A receptor 2; epithelial cell kinase       C385   (ECK); tyrosine-protein kinase receptor ECK   M59371 M36395   P29317           signal transducer &amp; transcription activator 5A       C388   (STAT5A);STAT5B   U47686   P51692; P42229       C48   collagen XVI alpha 1 subunit (COL16A1)   M92642   Q07092       C49   prostate-specific membrane antigen (PSM)   M99487   Q04609       C54   DNA mismatch repair protein MSH2   U04045; L47583   P43246           putative RHO/RAC guanine nucleotide exchange           factor (rho/rac GEE); faciogenital dysplasia protein       C56   1 (FGD1)   U11690   P98174       C63   metastasis-associated protein 1 (MTA1)   U35113   Q013330           DNA mismatch repair protein MSH6; mutS alpha           160-kDa subunit; G/T mismatch binding protein       P52701; Q43706;       C77   (GTMBP; GTBP)   U54777   O43917           nucleoside diphosphate kinase A (NDKA); NDP           kinase A; tumor metastatic process-associated           protein; metastasis inhibition factor NM23 (NM23-       C88   H1)   X17620   P15531       C90   collagen VI alpha 3 subunit (COL6A3)   X52022   P12111       C94   collagen VIII alpha 1 subunit (C0L8A1)   X57527   P27658           40S ribosomal protein 530 (RPS3O); Finkel-Biskis-           Reilly murine sarcoma virus ubiquitously expressed       P35544; Q05472;       C97   gene (FAU; FUB1)   X65923   Q95261       CA007   tousled-like kinase 2 (TLK2); PKU-alpha   AB004884   Q9Y4F7       CA008   STAT-induced STAT inhibitor 2   AB004903   Q14508       CA018   Janus tyrosine-protein kinase 2 (JAK2)   AF005216   Q60674       CA027   apoptotic protease activating factor 1 (APAF1)   AF013263   Q14727       CA034   DNA recombination &amp; repair protein HNGS1   AF022778   Q43475           mitogen-activated protein kinase kinase 7 (MAP           kinase kinase 7; MAPKK7; MAP2K7; PRKMK7);           MAPK/ERK kinase 7 (MEK7); c-jun N-terminal       CA035   kinase kinase 2 (JNKK2)   AF022805   Q14816; Q60452           cysteine-rich anigogenic inducer 61 (CYR61);           insulin-like growth factor-binding protein 10 (IGE-       CA043   binding protein 10; IGFBP10); GIG1   AF031385   Q00622; Q14934           cAMP-responsive element modulator 1 alpha       CA053   protein (HCREM)   D14825   Q14501           MCM2 DNA replication licensing factor; nuclear       CA057   protein BM28; KIAA0030   D21063   P49736       CA062   KIAA0078   D38551   Q60216                   P02593; P99014;                   P70667; Q61379;       CA066   calmodulin (CALM; CAM)   D45887   Q61380       CA070   cysteine protease   055696   Q99538       CA087   fibroblast adenine nucleotide translocator 2 (ANT2)   J02683   P05141; O43350       CA090   uroporphyringen III synthase   J03824   P10746       CA093   leukocyte lgG Fo receptor (FCGR)   J04162   P08637       CA103   interferon-gamma lEE SSP 5111   L07633   Q06323       CA111   aryl hydrocarbon receptor (AH receptor)   L19872   P35869       CA119   glutathione S-transferase theta 2 (GSTT2)   L38503   P30712       CA121   protein phosphatase 2A B56-alpha   L42373   Q15172       CA122   protein phosphatase 2A B56-beta (PP2A)   L42374   Q15173           protein phosphatase PP2A 61-kDa regulatory       CA124   subunit episilon   L76703   Q16537           signal transducer and activator of transcription 4       CA125   (STAT4)   L78440   Q14765           eukaryotic translation initiation factor 4E 25-kDa       CA127   subunit (EIF4E); mRNA cap-binding protein   M15353   P06730           2-oxoisovalerate dehydrogenase alpha subunit;           branched-chain alpha-keto acid dehydrogenase       CA131   component alpha subunit (BCKDH El-alpha)   M22221   P12694       CA134   elk-1; ets-related proto-oncogene   M25269   P19419       CA143   GTP-binding nuclear protein RAN (TC4)   M31469   P17080           cAMP-dependent protein kinase beta catalytic       CA152   subunit (PKAC-beta; PRKACB)   M34181   P22694           cAMP-dependent protein kinase gamma-catalytic       CA153   subunit (PKA C-gamma)   M34182   P22612       CA160   deoxycytidine kinase   M60527   P27707       CA167   complement component 5 (CS)   M65134   P01031       CA175   lymphocyte antigen   M81141   Q30099           interleukin 16 (IL16); lymphocyte chemoattractant       CA181   factor (LCF)   M90391   Q14005           serine/threonin protein phosphatase 2B catalytic           subunit gamma; calmodulin-dependent calcineurin           A subunit gamma; testic-specific calcineurin       CA186   catalytic subunit (CAM-PRP catalytic subunit)   S46622   P48454       CA197   serinelthreonine protein kinase   U07358   Q12852           serine/threonine-protein kinase NEK2; NI MA-           related protein kinase 2; NIMA-like protein kinase 1;       CA204   HSPK21   U11050   P51955       CA206   40S ribosomal protein S5 (RPS5)   U14970   P46782       CA226   58-kDa inhibitor of the RNA-activated protein kinase   U28424   Q13217       CA229   interleukin 15 receptor alpha subunit   U31628   Q13261       CA230   histone deaceytlase 2 (HD2)   U31814   Q92769       CA234   TAXI-binding protein 151 (TXBP151)   U33821   Q13311           glutathione synthetase (GSH synthetase; GSH-S);       CA237   glutathione synthase   U34683   P48637       CA242   xanthine dehydrogenase/oxidase   U39487   P47989           mothers against decapentaplegic homolog 4       CA251   (DPC4; MADH4; SMAD4)   U44378   Q13485       CA255   CREB-binding protein   U47741   Q92793       CA263   hint protein; protein kinase C inhibitor 1 (PKCI1)   U51004   P49773       CA271   serine/threonine protein kinase KRS2   U60207   Q15802       CA276   preferentially expressed antigen of melanoma   U65011   P78395       CA277   mitotic feedback control protein MADP2 homolog   U65410   Q13257           branched-chain amino acid aminotransferase       CA281   mitochondrial (BCAT(M))   U68418   O15382       CA290   HSIAH2   U76248   O43270       CA294   TSG10I tumor susceptibility protein   U82130   Q99816           maleylacetoacetate isomerase (MAA1); glutathione       CA299   transferase zeta 1   U86529   O43708           autoimmunogenic cancer/testis antigen NY-ESO-1;       CA300   LAG E-1   U87459   P78358           purine nucleoside phosphorylase (PNP); inosine       CA308   phosphorylase   X00737   P00491       CA313   cathepsin L; major excreted protein (MEP)   X12451   P07711           regulator of chromosome condensation; cell cycle       CA314   regulatory protein   X12654   P18754           ribonucleoside-diphosphate reductase M1 subunit;       CA328   ribonucleotide reductase   X59543   P23921           CMP-N-acetylneuraminate-beta-galactosamide-           alpha-2,6-sialyltransferase; beta-galactoside alpha-           2,6-sialyltransferase (alpha-2,6-ST);       CA331   sialyltransferase 1 (SIAT1); B-cell CD75 antigen   X62822   P15907           DNA primase small subunit; DNA primase 49-kDa       CA340   subunit   X74330   P49642           minichromosome maintenance deficient homolog 4       CA341   (MCM4); CDC21 homolog; CDC54 homolog   X74794   P33991; Q99658       CA350   thioredoxin reductase   X91247   Q16881       CA355   serine/threonine protein kinase   X97630   Q15524           secretogranin 1 (SGI; SOG1); chromogranin B       CA358   (CHGB)   Y00064   P05060           ets domain protein elk-3; NET; SRF accessory       CA379   protein 2 (SAP2)   Z36715   P41970           alpha-N-acetylneuraminnide alpha-2,8-           sialyltransferase; ganglioside GD3/GT3 synthase;       CA386   sialyltransferase 8 (SIAT8)   L32867   Q92185           glutamate-cysteine ligase regulatory subunit       CA387   (GLCLR); gamma-glutamylcysteine synthetase   L35546   P48507           estrogen receptor 1 (ESR1); estrogen receptor           alpha (ER-alpha; ESRA); fatty acid   M12674; X03635;   P03372; Q14276;       CA389   synthase/estrogen receptor fusion protein (FAS/ER)   U47678; AF172068   Q13511           soluble galactose-binding lectin 3 (LGALS3);           LGALS2; galectin 3, macrophage galactose-specific           lectin 2 (MAC2); galactoside-binding protein       CA394   (GALBP)   M35368   P17931; Q16005       CA397   LOX (Protein-lysine 6-oxidase, Lysyl-Oxidase)   M94054   P28300       CA401   stanniocalcin (STC)   U25997   P52823           RAD51 B, RAD51 LI, REC2, R51 H2 (DNA repair       CA406   protein RAD 51 Homolog 2)   U92074   O60914; O15315       CA407   SAP18 (Sin3 associated polypeptide P18)   U96915   Q00422       CA414   RAD51C truncated protein   AF029670   Q43503           chromodomain-helicase-DNA-binding protein 1       CA419   (CHD1)   AF006513   Q14646       CA420   CDC7-reiated kinase   AF015592   Q00311           stratifin (SFN); 14-3-3 protein sigma; epithelial cell       CA426   marker protein 1; HMEI   AF029082   P31947       CA431   testis-specific protein kinase 1   D50863   Q15569       CA438   KIAA0204   D86959   Q92603       CA444   microtubule-associated protein 1B   L06237   P46821       CA445   Von Hippel-Lindau tumor suppressor protein (VHL)   L15409   P40337       CA446   thymidylate kinase   L16991   P23919           A-raf proto-oncogene serine/threonine-protein       CA450   kinase; PKS2   L24038   P10398           importin beta 1 subunit; karyopherin beta 1 subunit;       CA452   importin 90; nuclear factor p97   L38951   Q14974           (2′-5′)oligoadenylate synthetase 1 ((2-5′)oligo(A)       CA459   synthetase 1; 2-5A synthetase 1)   M11810   P00973           eukaryotic translation initiation factor 2 alpha       CA482   subunit (EIF2-alpha)   U26032   none       CA487   betaine-homocysteine S-methyltransferase   U50929   Q93088       CA488   mitogen-responsive phosphoprotein DOC2   U53446   Q13598       CA498   MYD88   U70451   P78397       CA502   microsomal glutathione S-transferase 2 (MGST2)   U77604   Q99735           transcription factor activating enhancer-binding       CA506   protein 2 gamma (AP2-gamma; TFAP2C)   U85658   Q92754       CA508   serine kinase SRPK2   U88666   P78362       CA510   growth-arrest-specific protein 2 (GAS2)   U95032   Q43903       CA513   hemoglobin alpha subunit   V00491   P01922       CA518   trifunctional purine biosynthetic protein adenosine 3   X54199   P22102           major histocompatibility complex class II DM alpha       CA528   subunit (HLA-DMA); RING6   X62744   P28067       CA532   cardiac ventricular myosin light chain 2   X66141   Q14908       CA533   adenylosuccinate synthetase; IMP-aspartate ligase   X66503   P30520       CA540   uridine phosphorylase (UDRPase; UP)   X90858   Q16831; Q15362           neutrophil gelatinase-associated lipocalin (NGAL);           25-kDa alpha-2-microglobulin-related subunit of       CA546   MMP9); lipocalin 2; oncogene 24P3   X99133   P80188       CA547   adenine phosphoribosyltransferase (APRT)   Y00486   P07741           CCAATfenhancer-binding protein delta (C/EBP       CU012   delta); nuclear factor-IL-6 beta protein (NF-IL6-beta)   M83667   P49716; Q14937       CU038   DNA (cytosine-5-)-methyltransferase 2 (DNMT2)   AJ223333   Q14717       CU041   retinoblastoma-related protein p107   L14812   P28749           ATP-binding cassette subfamily B (MDRITAP)           member 1 (ABCB1); multiple drug resistance 1   P08183; Q12755;       CU043   protein (MOR1); P glycoprotein 1 (PGY1)   M14758   Q14812       CU047   glutathione S-transferase mu 4 (GSTM4)   M96233   Q03013                   P11137; Q99976;       CU048   microtubule-associated protein 2 (MAP2)   U01828   Q99975           lysophosphatidic acid G protein-coupled endothelial   Q92633; Q00722;       CU120   differentiation receptor 2 (EDG2); vzg-1z   U80811   Q00656; P78351           TTAGGG repeat binding factor 2 (hTRF2);       E011   telomeric DNA-binding protein   AF002999   Q15554           DNA polymerase epsilon subunit B; DNA       E017   polymerase II subunit B   AF025840   P56282           chondroitin sulfate proteoglycan 5 (CSPG5);       E046   neuroglycan C (NOC)   AF059274   Q95196           serine/threonin-protein kinase PAK-beta; p21 -       E054   activated kinase 3   AF068864   Q75914           growth arrest &amp; DNA damage-inducible protein 45       E065   gamma (GADD45 gamma)   AF078078   none       E069   cyclin D-binding MYB-like protein (hDMP1)   AF084530   Q9Y222       E075   ribosomal protein kinase B (RSKB)   AJ010119   Q75676           ferrochelatase; protoheme ferro-lyase; heme       E077   synthetase   D00726   P22830           proteasome (prosome, macropain) subunit alpha       E081   type 3 (PSMA3); HC8   D00762   P25788           peripheral myelin protein 22 (PMP22); CD25       E083   protein; SR13 myelin protein   D11428   Q01453       E096   photolyase/blue-light receptor homolog   D84657   Q16526           protein kinase C substrate 80-kDa protein heavy       E102   chain (PKCSH); 80K-H protein   J03075   P14314       E103   liver glucose transporter 2   J03810   P11168           serotransferrin (TF); siderophilin; beta-1-metal-       E118   binding globulin   M12530   P02787           DNA-binding protein A (DBPA); cold shock domain       E123   protein A (CSDA)   M24069   P16989; Q14121           26S protease regulatory subunit 6A; TAT-binding       E126   protein 1 (TBP1); proteasome subunit p50   M34079   P17980           solute carrier family 9 member 1 (SLC9A1);           sodium/hydrogen exchanger 1 (Na + /H+ exchanger       E130   1;NHE1)   M81768   P19634       E132   B94 protein   M92357   Q03169           RaIGDSB; GTP/GDP dissociation stimulator for a       E148   ras-related GTPase (RALGEF)   U14417   Q12967       E153   selenium-binding protein   U29091   Q13228           methionine aminopeptidase 2 (METAP2); peptidase           M2; initiation factor 2-associated 67-kDa       E154   glycoprotein   U29607   P50579       E159   leptin receptor (LEPR); OB receptor (OBR); FA   U43168   P48357       E160   myotubularin   U46024   Q13496           sodium/potassium-transporting ATPase beta 3           subunit (ATPB3); sodium/potassium-dependent       E161   ATPase   U51478   P54709           alpha-1-acid glycoprotein 1 (AGP1); orosomucoid 1       E178   (OMD1)   X02544   P02763           inter-alpha-trypsin inhibitor heavy chain H2 (ITI           heavy chain H2); inter-alpha-trypsin inhibitor       E181   complex component II   X07173   P19823           carboxypeptidase H (CPH); CPE; enkephalin           convertase; prohormone processing       E185   carboxypeptidase   X51405   P16870       E186   lactotransferrin; lactoferrin   X53961   P02788           major epididymis-specific protein E4 (hE4);       E188   epididymal secretory protein E4   X63187   Q14508           inter-alpha-trypsin inhibitor heavy chain H3 (ITI       E190   heavy chain H3)   X67055   Q06033       E193   tuberin; tuberous sclerosis 2 protein (TSC2)   X75621   P49815       E196   translin; recombination hotspot binding protein   X78627   Q15631           dipeptidyl-peptidase 1 (DPP-1); cathepsin C;       E198   cathepsin J; dipeptidyl transferase   X87212   P53634           ATP-binding casette 8 (ABC8); Drosophila white       E199   homolog   X91249   P45844           phosphatidylinositol-specific phospholipase C beta       E210   3 (PLC-beta 3; PLCB3)   Z16411   Q01970       E215   bystin   L36720   Q13895       E219   acrosin-trypsin inhibtor II; HUSI II   M91438   P20155       E220   emsl oncogene; cortactin (GUN); amplaxin   M98343   Q14247           autosomal dominant polycystic kidney disease II       E228   (PKD2)   U50928   Q13563       E230   organic cation transporter 1   U77086   Q15395       E231   alpha-fetoprotein; alpha-fetoglobulin   V01514   P02771       E232   C-reactive protein   X56692   P02741       E241   C-ets-2   J04102   P15036           heparin cofactor II (HCI1); protease inhibitor       E244   leuserpin 2 (hLS2)   M12849   P05546           ALPHA-l-MICROGLOBULIN/INTER-ALPHA-           TRYPSIN INHIBITOR LIGHT CHAIN (ITI-LC)       P02759; P00977;       E252   (PROTEIN HG) (HI-30) (BIKUNIN)   X04494   P02760           INTER-ALPHA-TRYPSIN INHIBITOR HEAVY           CHAIN HI (ITI HEAVY CHAIN H1) (INTER-ALPHA-           TRYPSIN INHIBITOR COMPLEX COMPONENT       P78455; Q01746;       E254   III)   X63652   P19827       G014   PTH/PTHrP receptor   L04308   Q03431           prostaglandin E2 receptor EP1 subtype (PTGER1);       G021   prostanoid EPI receptor   L22647   P34995           guanine nucleotide-binding protein G(K) alpha 3       G027   subunit (GNA3)   M27543; J03198   P08754           guanine nucleotide-binding protein G(Y) alpha 11       P29992; Q14350;       G037   subunit (GNA1 1)   M69013   O15109       H001   delta 7-dehydrocholesterol reductase (DHCR7)   AF034544   Q60492           sequalene monooxygenase (SQLE); squalene       H004   epoxidase (SE); ERG1   D78130   Q14534       H008   hydroxymethylglutaryl-CoA lyase L07033   P35914           CAAX-box farnesyltransferase alpha (FTase-alpha;       H010   ENTA)   L10413   P49354       H022   corticosteroid 1 1-beta-dehydrogenase isozyme 2   U14631   Q13194; P80365       H025   apolipoprotein Al (APOA1)   X00566   P02647       H026   apolipoprotein CII (APQC2)   X00568   P02655       H030   apolipoprotein B100 (APOBiQO)   X04506   P04114       H039   mitochondrial hydroxymethylglutaryl-CoA synthase   X83618   P54868       H040   rab geranylgeranyl transferase beta subunit   Y08201   P53611; Q92697       H055   tissue inhibitor of metalloproteinase 3 (TIMP3)   U14394   P35625           3-beta-hydroxy-delta-5-steroid           dehydrogenase/steroid delta isomerase 1       P14060; Q14545;       H058   (HSD3B1); HSD3B2   M27137; M67466   P26439       H073   matrix metalloproteinase 2 (MMP2)   J03210   P08253           sterol O-acyltransferase 1 (SOAT1); acyl-CoA:       H078   cholesterol acyltransferase (ACAT)   L21934   P35610           sterol regulatory element-binding transcription       H081   factor 1   U00968   P36956       H085   oxysterol-binding protein (0SBP) M8691 7;   J04757   P22059       H092   apolipoprotein CIV (AP0G4)   U32576   P55056       H094   mitochondrial glycerol-3-phosphate dehydrogenase   U12424   P43304       H099   alcohol sulfotransferase   L20000   Q06520       H103   angiotensinogen (AGT)   K02215   P01019       H104   renin   L00073   P00797       H105   angiotensin 1 converting enzyme   J04144   P12821       H108   endothelin 1 (ET1)   Y00749   P05305       H115   alcohol dehydrogenase 5 clii polypeptide   M30471   P11766       H116   alcohol dehydrogenase class II pi subunit   M15943   P08319           alpha 1 B adrenergic receptor (ADRAI B); alpha 1 B       H134   adrenoceptor   U03865   P35368           hydroxysteroid 17-beta dehydrogenase 3           (HSD17B3); estradiol 17-beta dehydrogenase 3       H149   (EDHI7B3)   U05659   P37058           brain fatty acid-binding protein (B-FABP); FABP7;       H152   brain lipid-binding protein (BLBP)   AJ002962   O15540; O14951       H156   caveolin2   AF035752; U32114   P51636           caveolin 3 (CAV3); limb-girdle muscular dystrophy       H157   type IC (LGMD1C); VIP21   AF043101   P56539       H159   LDL-associated phospholipase A2   U20157   Q15692; Q13093           vasoactive intestinal polypeptide receptor 2   P41587; Q15870;       H166   (VIPR2); pituitary adenylated cyclase activating   L40764   Q13053           polypeptide receptor 3 (PACAP3 receptor;           PACAPR3); helodermin-preferring receptor           nuclear receptor subfamily 3 group C member 1           (NR3C1); lymphocyte glucocorticoid receptor (GRL;       H170   GCR)   M10901   P04150; P04151       H178   steroid receptor coactivator 1 (SRC1)   U59302   Q00150           estrogen-related receptor alpha (ERR-alpha;       H180   ESRRA); estrogen receptor-like 1 (ESRL1)   X51416; Y00290   P11474; 014514       H194   prothrombin; coagulation factor II   V00595   P00734                   Q16001; Q15190;       H196   autoprothrombin IIA   X02750   Q15189; P04070       H201   amyloid-like protein 2   S60099   Q06481       H207   signal transducer CD24   M58664   P25063       H209   macrosialin   S57235   P34810       H210   selectin P ligand   U02297   Q14242; Q12775       H218   alpha-2-antiplasmin   D00174   P08697       H222   GAP junction alpha-4 protein   M96789   P35212       H238   protein 4.1   M14993   P11171       H241   vinculin   M33308   P18206           ubiquitously expressed nuclear receptor (U N R;           NER); nuclear receptor subfamily 1 group H           member 2 (NR1 H2); oxysterols receptor LXR beta       H260   (LXRB)   U07132   P55055       H262   retinoid X receptor gamma (RXR-gamma; RXRG)   U38480   P48443                   Q13440; Q13441;       H266   retinoic acid receptor alpha (RAR-alpha; RARA)   X06614   P10276                   Q15067; Q15068;                   Q12863; Q15101;       H279   peroxisomal acyl-coenzyme A oxidase   S69189   Q16131       H295   tumor-associated antigen L6   M90657   P30408           vascular ATP-diphosphohydrolase (ATPDase);       H298   lymphoid cell activation antigen; 0039 antigen   S73813   P49961           insulin-responsive glucose transporter type 4           (GLUT4); solute carrier family 2 member 4       H312   (SLC2A4)   M20747   P14672       H321   cardiac muscle troponin T (TNTC)   S64668   P45379; Q99596           sodium/potassium-transporting ATPase gamma           subunit (Na +/K+ ATPase gamma; ATP1G1;       H328   ATP1C); sodium pump gamma subunit   U50743   P54710           alpha-galactosidase A; melibiase; alpha-D-       H330   galactoside galactohydrolase   X05790   P06280       H345   type Vcollagen alpha 2 subunit   Y14690   P05997                   P02452; 015176;       H348   collagen 1 alpha 1 subunit (COLlA1)   K01228   Q14037       H349   dodecenoyl-coenzyme A delta isomerase   L24774   P42126       H350   collagen XV alpha 1 subunit (COLISA1)   L25286   P39059       H352   collagen IValpha 1 subunit (COL4A1)   M11315   P02462       H357   collagen V alpha 1 subunit (COL5A1)   M76729   P20908       H363   collagen VI alpha 1 subunit (COL6A1)   X15880   P12109       H367   cytochrome P450 11B6 (CYP2B6); CYP2B3   M29874; J02864   P20813                   Q02928; Q16865;       H374   cytochrome P450 IVAl 1 (CYP4A1 1); CYP4A2   L04751   Q16866       H383   cytochrome P450 XIXA1 (CYP19A1)   M22246   Q16731; P11511       H392   steroidogenic acute regulatory protein   U17280   P49675       H393   Niemann-Pick C disease protein (NPC1)   AF002020   Q15118           platelet-activating factor acetylhydrolase IB alpha       H403   subunit   L13387   P43034           platelet-activating factor acetylhydrolase IB gamma       H404   subunit   D63391   Q15102           platelet-activating factor acetylhydrolase IB beta       H405   subunit   D63390   Q00687; Q29459       H408   platelet glycoprotein IX   HS1144   P14770       H417   profilin I   J03191   P07737           annexin VI (ANX6); lipocortin VI; protein III;           chromobindin 20; 67-kDa calelectrin; calphobindin-II       N003   (CPB-l1)   D00510   P08133       N004   pyruvate kinase R/L (PKLR); PK1   D10326   P30613; P11973           lysosome membrane protein II (LIMP II); 85-kDa           lysosomal membrane sialoglycoprotein (LGP85);       N005   CD36 antigen-like 2 (CD36L2)   D12676   Q14108           mitochondrial trifunctional protein enoyl-CoA           hydratase/3-hydroxyacyl-CoA dehydrogenase alpha       N011   subunit   D16480   P40939           RAB GDP dissociation inihibitor alpha (RAB GDI       N026   alpha); GDI-1; XAP-4   D45021   P31150; P50394                   P10636; P18518;       N037   microtubule-associated protein tau (MAPT); MTBTI J03778   Q14799; Q15551       N041   annexin VII (ANX7); synexin   J04543   P20073           phenylalanine-4-hydroxylase (PAH); phe-4-       N045   monooxygenase   K03020   P00439           protein-tyrosine phosphatase 2C (PTP-2C); SH-       N060   PTP2   L08807   Q06124           glycerol kinase (GK); ATP:glycerol 3-       N066   phosphotransferase; glycerokinase   L13943   P32189           phosphatidylinositol 4-kinase alpha (P14-kinase;       N083   PTDINS-4-kinase; P14K-alpha)   L36151   P42356       N089   apolipoprotein E (APOE)   M12529   P02649           beta-hexosaminidase alpha chain; N-acetyl-beta-       N092   glucosaminidase; beta-N-acetylhexosaminidase   M13520   P06865       N093   myelin basic protein (MBP)   M13577   P02686       N096   beta-glucuronidase (beta-G 1)   M15182   P08236       N099   glutamate dehydrogenase 1 (GDH; GLUD1)   M18377   P00367           annexin IV (ANX4); ANXA4; placental anticoagulant       N100   protein II (PAP-I1)   M19383   P09525           annexin III (ANX3); lipocortin III; placental           anticoagulant protein III) (PAP-III); 35-alpha           calcimedin; inositol 1,2-cyclic phosphate 2-       N101   phosphohydrolase   M20560; J03899   P12429       N110   ras-related protein RAB1A; YPT1 -related protein   M28209   P11476       N121   ADP-ribosylation factor 1 (ARF1)   M36340   P32889; P10947       N122   acetylcholinesterase (ACHE)   M55040   P22303           myristoylated alanine-rich O-kinase substrate           (MARCKS); protein kinase C substrate 80-kDa       N135   protein light chain (PKCSL)   M68956   P29966       N139   hexokinase 1 (HK 1); brain-form hexokinase   M75126   P19367       N142   calpactin 1 light chain   M81457   P47736           protein phosphatase 2C alpha isoform (PP2C-       N166   alpha)   S87759   P35813           tyrosine-protein kinase FRK; nuclear tyrosine       N168   protein kinase RAK   U00803   P42685; Q13128           protein-tyrosine phosphatase eta (R-PTP-eta);           density-enhanced phosphatase 1 (DEP1); CD148       N179   antigen; PTPRJ   U10886   Q12913       N187   lumican (LUM); keratan sulfate proteoglycan; LDC   U18728; U21128   P51884       N213   protein phosphatase 2A Balphal regulatory subunit   U37352   Q13362                   O00754; Q93094;       N239   LYSOSOMAL ALPHA-MANNOSIDASE   U60266   Q16680; O15330       N249   syntaxin 7 (STX7)   U77942   Q15400       N255   c factor receptor beta (GDNFR-beta)   U93703   Q15316           annexin V; lipocortin V; endonexin II; caiphobindin I           (CBP-1) ; placental anticoagulant protein 1 (PAP-1);           PP4; thromboplastin inhibitor; vascular       N263   anticoagulant-alpha (VAC-alpha; anchorin CII   X12454   P08758           fur; furin; paired basic amino acid residue cleaving       N273   enzyme (PACE); dibasic processing enzyme   X17094   P09958; Q14336           diacylglycerol kinase alpha (DGK-alpha; DAG   P23743; O75481;       N288   kinase alpha); 80-kDa diglyceride kinase   X62535   Q75482; Q75483           mannosyl-oligosaccharide alpha-1,2-mannosidase;       N304   Man9-alpha-mannosidase   X74837   P33908           microsomal triglyceride transfer protein (MTP) 97-       N305   kDa subunit   X75500   P55157       N315   calcium-binding protein ERC-55   X78669   Q14257           serine/threonine protein phosphatase 5 (PP5);       N331   protein phosphatase T (PPT)   X89416   P53041; Q16722           DNA polymerase gamma (POLG); mitochondrial       N344   DNA polymerase catalytic subunit (MDP1)   X98093   P54098; Q92515           Alzheimer&#39;s disease amyloid A4 protein; protease       N348   nexin-II (PN-II); APPI   Y00264   P05067; P09000           dolichyl-diphosphooligosaccharide-protein       N349   glycosyltransferase 67-kDa subunit; ribophorin I   Y00281   P04843       N356   vesicle-membrane fusion protein SNAP23A   Y09567   Q00161       N364   laminin alpha 2 subunit (LAMA2); laminin M chain   Z26653   P24043; Q14736           (LAMM); merosin heavy chain           43-kDa postsynaptic protein; acetyicholine receptor-       N366   associated 43-kDa protein; RAPSYN   Z33905   Q13702       N378   glial fibrillary acidic protein (GFAP)   J04569   P14136       N381   dynamin 1   L07807   Q05193           beta-adaptin 1; plasma membrane adaptor           HA2JAP2 adaptin beta subunit; clathrin assembly           protein complex 2 beta large subunit; AP10SA;       N385   ATDB1; BAM22   L13939   Q10567; P78436           dystroglycan; dystrophin-associated glycoprotein 1       N389   (DAG1)   L19711   Q14118       N393   dynamin 2   L36983   P50570       N396   creatine kinase M subunit   M14780   P06732       N401   casein kinase II alpha subunit (CK I1); CSNK2A2   M55268   P19784           protein phosphatase PP2A 55-kDa regulatory           subunit neuronal isoform; protein phosphatase       N409   PP2A B subunit beta; beta-PR55   M64930   Q00005                   P22307; Q16622;       N412   sterol carrier protein 2 (SCP2)   M75883   Q15432       N416   somatostatin receptor 2 (SSTR2; SS2R); SRIF1   M81830   P30874           glutamate decarboxylase 67-kDa isoform; 67-kDa       N418   glutamic acid decarboxylase (GAD-67); GAD1   M81883   Q99259           endothelial nitric oxide synthase (EC-NOS; ENOS);   P29474; Q14251;       N424   type III NOS   M93718   Q14434           MAP kinase-activated protein kinase 2 (MAPKAP       N430   kinase 2; MAPKAPK-2)   U12779   P49137           tyrosine 3-monooxygenase/tryptophan 5-           monooxygenase activation protein epsilon           polypeptide (YWHAE); 14-3-3 protein epsilon;           protein kinase C inhibitor protein 1 (KCIP1);       P42655; P29360;       N433   mitochondrial import stimulation factor L subunit   U28936   Q63631           serine/threonine protein phosphatase PP2A-alpha       N442   catalytic subunit   X12646   P05323; P13197           cAMP-dependent protein kinase type II alpha       N446   regulatory subunit (PRKAR2A; PKR2)   XI4968   P13861; Q16823           phosphatidylinositol-4-phosphate 5-kinase type III           (PIP5K3); PTDINS(4)P-5-kinase C isoform;           diphosphoinositide kinase + phosphatidylinositol-4-           phosphate 5-kinase type II alpha (PIP5K2A);       N460   PTDINS(4)P-5-kinase B isoform   S78798 + U14957   P53807 + P48426       N466   ras-related protein RAB5B   X54871   P35239; P35277           14-3-3 protein beta/alpha; protein kinase C inhibitor       N469   protein-1 (KCIP-1); protein 1054   X57346   P31946       N474   caltractin 1 (CALT); centrin 2 (GETN2; CEN2)   X72964   P41208       N478   ras-related protein RAB11B; YPT3   X79780   Q15907       N479   casein kinase 1 alpha 1 (CSNKIA1)   X80693   P48729           serine/threonine protein phosphatase beta 1       N480   catalytic subunit (PP1CB; PPPIB; PP1B)   X80910   P37140       N488   protein kinase C zeta type (NPKC-zeta)   Z15108   Q05513           basic helix-loop-helix domain-containing protein           class B2 (BHLHB2); differentiated embryo       P003   chondrocyte-expressed gene 1 (DEC1)   AB004066   Q14503       P007   zinc finger protein UBID4   AF001433   Q92785           segment polarity protein dishevelled homolog 2       P008   (DVL2)   AF006012   Q14641       P011   mothers against dpp homolog 7 (SMAD7; MADH7)   AF015261   Q14740           POD1 mesoderm-specifc basic helix-loop-helix       P014   protein   AF035718   Q43545           cysteine- &amp; glycine-rich protein 2 (CSRP2; CRP2);       P022   smooth muscle cell LIM protein (SMLIM)   D42123   P52943           early growth response protein 2 (EGR2); KROX20       P026   homolog   J04076   P11161           sex-determining region Y box-containing gene 2       P028   (SRY box-containing gene 2; SOX2)   L07335   P48431; Q14537                   Q14762; Q15719;       P036   presenilin 1 (PSNLI; PSEN1; PS1)   L42110   Q15720; P49768       P038   presenilin 2 (PSEN2; PSNL2; PS2)   L43964   P49810           inhibin beta B subunit (INHBB); activin beta B       P040   subunit   M31682   P09529           TCF1 homeobox protein; hepatocyte nuclear factor           1 alpha (HNFIA); liver-specific transcription factor       P043   LBB1   M57732   P20823       P046   MAX protein   M64240   P25912; P52163           SEF2-1B protein; helix-loop-helix DNA-binding   P15884; Q15439;       P048   protein   M74719   Q15440           sex-determining region Y box-containing gene 5       P056   (SRY box-containing gene 5; SOX5)   583308   P35711       P060   homeobox protein MOX-1   U10492   P50221       P063   CHUK helix-loop-helix protein   U22512   Q13132; Q92467       P085   caudal-type homeobox protein 2 (CDX2); CDX3   U51096   Q00503; Q99626                   Q15910; Q92857;       P086   enhancer of zeste homolog 2 (EZH2)   U52965   Q15755           hepatocyte nuclear factor 3 forkhead homolog 4       P102   (HFH4)   U69537   Q92949; Q00630                   O00167; Q99503;       P107   eyes absent homolog 2 (EYA2)   U71207   Q99812           transforming growth factor beta 4 (TGF-beta 4);       P116   endometrial bleeding-associated factor   U81523   Q00292       P117   homeobox protein B13 (H0XB13)   U81599   Q99810; Q92826       P118   eyes absent homolog 3 (EYA3)   U81602   Q99504; Q99813           neurogenic locus notch protein homolog 3       P124   (NOTCH3)   U97669   none           secreted phosphoprotein 1 (SSP1); osteopontin           (OPN); bone sialoprotein 1 (BSPI; BNSP); early T-       P10451; Q15681;       P126   lymphocyte activation protein 1 (ETA1)   X13694   Q15682; Q15683       P137   homeobox protein 8 (HOX8); MSX2   X69295   P35548           homeobox protein MOX-2; growth arrest-specific       P144   homeobox protein   X82629   P50222                   Q15672; Q92487;       P151   twist-related protein   X99268   Q99804       P162   caudal-type homeobox protein 1 (CDX1)   U51095   P47902           paired mesoderm homeobox protein 1 (PHOXI;       P169   PMX1); aristaless homolog   M95929   P54821       P176   CTG3a; numb-like protein   U80758   none           sex-determining region Y box-containing gene 9           (SRY box-containing gene 9; SOX9); campomelic           dysplasia protein 1 (CMPDI; CMD1); autosomal       P186   sex-reversal protein 1 (SRA1)   Z46629   P48436           neurofilament triplet L protein (NFL); 68-kDa       P193   neurofilament protein   X05608   P07196; Q16154           neurofilament triplet H protein (NFH); 200-kDa       P194   neurofilament protein   X15306   P12036           syndecan2 (SYND2); fibroglycan; heparine; sulfate       P198   proteoglycan core protein 0 (HSPG)   J04621   P34741           nck, ash &amp; phospholipase C gamma-binding protein       S1   (NAP4)   AB005216   O14512       S10   DNA polymerase beta (POLB)   D29013   P06746       S100   DNA topoisomerase II beta (TOP2B)   X68060   Q02880           N-oxide-forming dimethylaniline monooxygenase 4;       S101   hepaticflavin-containing monooxygenase 4 (FMO4)   Z11737   P31512           xeroderma pigmentosum group F complementing           protein (XPF); excision repair cross-complementing           rodent repair deficiency complementation group 4       S102   (ERCC4); ERC01 1   L77890   Q92889; Q00140           70-kDa heat shock protein 5 (HSPA5); 78-kDa           glucose-regulated protein (GRP78);       S103   immunoglobulin heavy chain binding protein (BIP)   M19645   P11021       S104   V(D)J recombination activating protein 2 (RAG2)   M94633   P55895           DNA mismatch repair protein PMS1 (PMS1 protein       S105   homolog 1)   U13695   P54277           DNA mismatch repair protein PMS2 (PMS1 protein       S106   homolog 2)   U13696   P54278           replication protein A 30-kDa subunit; replication       S107   factor A protein 4 (RPA4; RFA)   U24186   Q13156       S108   mutY homolog (hMYH)   U63329   Q15830       S109   beta crystallin A4 (CRYBA4)   U59057   P53673           T-complex protein 1 epsilon subunit (TCP1-       S11   epsilon); CCT-epsilon (CCTE; CCT5)   D43950   P48643       S111   beta crystallin BI (CRYBB1)   U35340   P53674       S112   beta crystallin B2 (CRYBB2); BP   L10035   P43320       S113   beta crystallin 83 (CRYBB3; CRYB3)   U71216   P26998; Q92965       S114   B-lymphocyte germinal center kinase (GC kinase)   U07349   Q12851           cytochrome P450 11A6 (CYP2A6); CYP2A3;   M33318; X13930;   P11509; P10890;       S115   coumarin 7-hydroxylase   X13897   P00190; Q16803           3-mephenytoin 4 hydroxylase; cytochrome P450   M21940; M15331;   P11712; P11713;           IIC9 (CYP2C9); CYP2C10; CYP2C17; CYP2C18;   M21939; M61858;   P33259; P33260;       S116   CYP2C19   M61854   P33261           interferon-inducible RNA-dependent protein kinase       S117   (P68 kinase)   M35663; U50648   P19525           mitochondrial heat shock 10-kDa protein (HSP10);       S118   HSPE1; 10-kDa chaperonin (CPN10)   U07550   Q04984; Q95421           heat shock 17-kDa protein (HSP17); HSPL27;       S119   HSPB3   U15590   Q12988       S12   probable protein disulfide isomerase P5   D49489   Q15084           90-kDa heat-shock protein beta (HSP90); 84-kDa       S120   heat-shock protein beta (HSP84); HSPCB   M16660   P08238           heat shock 70-kDa protein 6; heat shock 70-kDa       S121   protein B   X51757; M11236   P48741           heat shock cognate 71-kDa protein; heat shock 70-       S122   kDa protein 8 (HSPA8; HSC70); HSP73   Y00371   P11142       S123   heat shock-related 70-kDa protein 2   L26336   P54652       S124   cytochrome P450 IIE1 (CYP2E1)   J02625   P05181       S125   cytochrome P450 IIF1 (CYP2F1)   J02906   P24903           microsomal UDP-glucuronosyltransferase 1-6       S126   (UDPGT; UGTI.6; UGT1F; GNT1)   J04093   P19224       S127   glutathione S-transferase mu 3 (GSTM3); GST5   J05459   P21266           cytochrome P450 IAl (CYPIA1); P450-P1; P450       S128   form 6; P450-C   K03191   P04798           peroxisome proliferatitve-activated receptor alpha       Q07869; Q92689;       S129   (PPAR-alpha; PPARA)   L02932   Q16241; Q92486       S13   protein disulfide isomerase-related protein (PDIR)   D49490   Q14554           soluble epoxide hydrolase (SEH); cytosolic epoxide           hydrolase (CEH; EPHX2; EPH2); epoxide       S130   hydratase   L05779   P34913           liver carboxylesterase; acyl coenzyme A:cholesterol       P23141; Q16737;           acyltransferase (ACAT); monocytelmacrophage   Q14062; Q13657;       S131   serine esterase (hMSE); CES2   L07765   Q00015           serum paraoxonase/arylesterase 2 (PON2); serum           aryldiakylphosphatase 2; aromatic esterase 2 (A-       Q15165; O15114;       S132   esterase 2)   L48513   O15115; O75856           serum paraoxonase/arylesterase 3 (PON3); serum           aryldiakylphosphatase 3; aromatic esterase 3 (A-       Q15166; O75855;       S133   esterase 3)   L48516   O76060           cytochrome P450 XXIB (CYP21 B); CYP21A2;       P08686; P04033;       S134   steroid 21-hydroxylase   M12792; M23280   Q01204           mitochondrial cytochrome P450 XIA1 (CYP11A1);       S135   P450 cholesterol side chain cleavage (P450SCC)   M14565   P05108           cytochrome P450 11D6 (CYP2D6); P450-DB1;       S136   debrisoquine 4-hydroxylase   M20403   P10635; Q16752           microsomal UDP-glucuronosyltransferase 1-1           (UDPGT; UGTI.1; UGTIA; GNT1); bilirubin-specific       S138   isozyme 1 (hUG-BR1)   M57899   P22309       S139   microsomal UDP-qlucuronosyltransferase 1-4   M57951   P22310           (UDPGT; UGTI.4; UGTID; ONT1); bilirubin-           specific isozyme 2 (hUG-BR2)       S14   YSK1; Ste20 &amp; SPS1-related kinase D63780 000506           serum paraoxonase/arylesterase 1 (PON1); serum           aryldiakylphosphatase 1; aromatic esterase 1 (A-       S140   esterase 1)   M63012   P27169           membrane-bound &amp; soluble catechol-0-       S141   methyltransferase (COMT)   M65212   P21964       S142   monoamine oxidase A (MAOA)   M68840   P21397; Q16426           flavin-containing amine oxidase B; monoamine       S143   oxidase (MAOB)   M69177   P27338           eukaryotic peptide chain release factor subunit 1       S145   (ERF1); TB3-1; Cli protein   M75715   P46055           microsomal UDP-glucuronosyltransferase 1-3       S146   (UDPGT; UGTI.3; UGTIC; GNT1)   M84127   P35503           structure-specific recognition protein 1 (SSRP1);           recombination signal sequence recognition protein;       S147   T160   M86737   Q08945           microsomal UDP-glucuronosyltransferase 1-2       S148   (UDPGT; UGTI.2; UGT1B; ONT1); HLUGP4   S55985   P36509                   P51580; O43213;                   O14806; O15515;       S149   thiopurine 5-methyltransferase (TPMT)   S62904   O15423           meiotic recombination protein DMC1/LIM15       S15   homolog   D63882   Q14565; Q99498           short/branched chain-specific acyl-CoA           dehydrogenase (SBCAD; ACADSB); 2-methyl           branched chain acyl-CoA dehydrogenase (2-       S150   MEBCAD)   U12778   P45954           polymorphic arylamine N-acetyltransferase (PNAT)       S151   + monomorphic (MNAT)   X14672; X17059   P18440           glutathione peroxidase-gastrointestinal (GSHPX-           01); glutathione peroxidase-related protein 2       S152   (GPRP)   X53463   P18283           cytochrome P450 XIB1 (CYPIIB1); steroid 11-       S153   beta-hydroxylase (SI 1 BH)   X55764   P15538       S154   cytochrome P450 IVAl 1 (CYP4A1 1)   X71480   Q06766       S156   bleomycin hydrolase (BLM hydrolase)   X92106   Q13867       S157   diaphorase 1 (DIA1); cytochrome b5 reductase   Y09501   P00387           coproporphyrinogen III oxidase (CPO);       S158   coproporphyrinogenase; coprogen oxidase (COX)   Z28409   P36551           11 0-kDa heat-shock protein (HSP110); 105-kDa       S16   heat-shock protein (HSP105); KIAAO201   D86956   Q92598; Q95739           gamma crystallin C (CRYGO; CRYG3; gamma           crystallin 2 + gamma crystallin B (CRYOB;   U66582 + M11971;       S160   CRYG2); gamma crystallin 1-2   M11970   P07315 + P07316       S17   heat shock transcription factor 4 (HHSF4)   D87673   Q99472       S18   cytochrome P450 IVBI (CYP4B1); P450-HP   J02871   P13584       S19   copper-zinc-containing superoxide dismutase 3   J02947   P08294           (Cu-Zn SOD3); extracellular SOD (ECSOD)       S2   DNAJ protein homolog 2 (DNAJ2; hDJ2; HSJ2)   D13388   P31689           DNA mismatch repair protein MSH3; divergent           upstream protein (DUP); mismatch repair protein 1       S20   (MRP1)   J04810   P20585; Q92867       S21   protein disulfide isomerase-related protein ERP72   J05016   P13667           replication protein A 32-kDa subunit (RPA32);       S22   replication factor A protein 2 (RFA; RPA2)   J05249   P15927           mu-crystallin homolog (CRYM); NADP-regulated       S23   thyroid hormone-binding protein (THBP)   L02950   Q14894           ATP-binding cassette subfamily C member 1           (ABCC1); multidrug resistance-associated protein 1       S24   (MRP1)   L05628   P33527; Q14819           replication protein A 14-kDa subunit (RP-A) (RF-A);       S25   replication factor A protein 3   L07493   P35244           calnexin (CANX); major histocompatibility complex   L10284; L18887;       S26   class 1 antigen-binding protein p88; 1P90   M94859; M98452   P27824           cyclophilin 40 (CYP4Q; CYPD); 40-kDa peptidyl-           prolyl cis-trans isomerase (PPlase); rotamase;       S27   cyclophilin-related protein   Li 1667   Q08752           heat shock 70-kDa protein 4 (HSPA4); HSP70RY;       S28   heat shock 70-related protein APG-2   L12723   P34932; 095756           quinone oxidoreductase; NADPH:quinone       S29   reductase; zeta-crystallin (CRYZ)   L13278; S58039   Q08257           T-complex protein 1 theta subunit (TCPI-theta);       S3   CCT-theta (CCTQ; CCT8); KIAA00O2   D13627   P50990           mitochondrial stress-70 protein; 75-kDa glucose-           regulated protein (GRP75); peptide-binding protein       P38646; P30036;       S30   74 (PBP74); mortalin (MOT); HSPA9B   L15189   P31932           p23; 23-kDa progesterone receptor-associated       S31   protein   L24804; L24805   Q15185           FLAP endonuclease 1 (FEN 1); maturation factor 1       S33   (MF1)   L37374   P39748           DNA nucleotidylexotransferase; terminal addition           enzyme; terminal deoxynucleotidyltransferase       S34   (DNTT; TDT)   M11722; K01919   P04053           poly(ADP-ribose) polymerase (PARP; ADPRT;           ADPRP; PPOL); NAD(+) ADP-ribosyltransferase;       S35   poly(ADP-ribose) synthetase   M18112; J03473   P09874       S36   V(D)J recombination activating protein 1 (RAG1)   M29474   P15918                   M34539; M80199;           FK506-binding protein 12 (FKBP12); peptidyl-prolyl   M92423; X55741;       S37   cis-trans isomerase (PPlase); rotamase   X52220   P20071           ATP-dependent DNA ligase 1 (LIG 1);       S38   polydeoxyribonucleotide synthase   M36067   P18858           FK506-binding protein 13 (FKBP13); FKBP2;       S39   peptidyl-prolyl cis-trans isomerase (PPlase)   M65128   P26885           xeroderma pigmentosum group A complementing       S4   protein (XPA)   D14533   P23025       S40   heat shock transcription factor 2 (HSTF2; HSF2)   M65217   Q03933           DNA-3-methyladenine glycosylase (ADPG); 3-           alkyladenine DNA glycosylase; N-methylpurine-       S41   DNA glycosirase (MPG)   M74905   P29372       S42   DNA polymerase delta catalytic subunit   M80397   P28340           caireticulin (CRP55); cairegulin; HACBP; ERP60;       S43   52-kDa ribonucleoprotein autoantigen R01SS-A   M84739   P27797           stress-induced phosphoprotein 1 (STIP1);           HSP70/HSP90-organizing protein (HOP); IEF-SSP-       S44   3521   M86752   P31948           alpha crystallin B subunit (alpha(B)-crystallin;       S45   CRYAB; CRYA2); Rosenthal fiber component   S45630   P02511           heat shock protein beta 2 (HSPB2); DMPK-binding       S46   protein; MKBP   S67070   Q16082       S47   alpha crystallin A chain (CRYAA; CRYA1)   U05569   P02489       S48   nicotinamide N-methyltransferase (NNMT)   U08021   P40261           microsomal UDP-glucuronosyltransferase 2B 15   U08854; X63359;           (UDPGT); UDPGTH-3; UGT2BI5 + microsomal   U06641; J05428;       S49   2B10 (UDPGT); UGT2B10 + 2microsomal B8   Y00317   P54855           probable protein disulfide isomerase ER-60           (ERP60); 58-kDa microsomal protein;   D16234; Z49835;       S5   phospholipase C alpha (PLC-alpha; PLCA)   D83485; U42068   P30101           phenol-sulfating phenol sulfotransferase 1 (PPST1);           thermostable phenol sulfotransferase (TS-PST);           HASTI/HAST2; ST1A3; STP1+ PPST2; ST1A2;           STP2 + monoamine-sulfating phenol   U09031 + U28170 +   P50225 + P50226 +       S50   sulfotransferase   L19956   P50224           NADP+ dihydropyrimidine dehydrogenase (DPD);           dihydrouracil dehydrogenase; dihydrothymine       Q12882; Q16694;       S51   dehydrogenase (OPYD)   U09178   Q16761           transcriptional regulator atrX; X-linked helicase II       P46100; P51068;       S52   (XH2); X-linked nuclear protein (XNP); RAD54L   U09820   Q15886           tumor necrosis factor type 1 receptor-associated       S53   protein (TRAP1)   U12595   Q12931; O75235           265 proteasome regulatory subunit S2 (PSMD2);           tumor necrosis factor type 1 receptor-associated       Q13200; Q12932;       S54   protein (TRAP2); 55.11 protein   U12596   Q15321           damage-specific DNA-binding protein p127 subunit       S55   (DDBA p127); DOBi   U18299   Q16531           damage-specific DNA binding protein p48 subunit           (DDBB P48); implicated in xeroderma pigmentosum       S56   group E (DDB2)   U18300   Q92466           cockayne syndrome group A; WO-repeat protein       S57   (CSA protein)   U28413   Q13216           HSC70-interacting protein; progesterone receptor-       S58   associated P48 protein   U28918   P50502           T-complex protein 1 delta subunit (TCP1-delta);           CCT-delta (CCTD; CCT4); stimulator of tar RNA       S59   binding (SRB)   U38846   P50991; O14870           7,8-dihydro-8-oxoguanine triphosphatase (8-oxo-       S6   dGTPase); mutT homolog 1 (MTH1)   D16581   P36639           X-ray repair-complementing defective repair in       S60   Chinese hamster cells 4 (XRCC4)   U40622   Q13426       S61   DNA topoisomerase III alpha (TOP3A)   U43431   Q13472; Q13473       S62   G/T mismatch-specific thymine DNA glycosylase   U51166   Q13569           (TDG)       S63   150-kDa oxygen-regulated protein (ORPI50)   U65785   none           X-ray repair-complementing defective repair in       S64   Chinese hamster cells 9 (XRCC9)   U70310   O15287       S65   48-kDa FKBP-associated protein (FAP48)   U73704   Q92990       S66   endonuclease III homolog 1; HNTH1; OCTS3   U79718   Q99794           T-complex protein 1 eta subunit (TCP1-eta); COT-       S67   eta (COTH; CCT7); HIV-1 NEF interacting protein   U83843   Q99832; O14871       S68   catalase (CAT)   X04076   P04040           porphobilinogen deaminase (PBGD);           hydroxymethylbilane synthase (HMBS); pre-       P08397; P08396;       S69   uroporphyrinogen synthase   X04808   Q16012           xeroderma pigmentosum group C complementing       S7   protein (XPC)   D21089   Q01831       S70   heme oxygenase 1 (H01; HMOX1)   X06985   P09601                   P04179; P78434;       S71   Mn+ superoxide dismutase 2 (SOD2)   X07834; X59445   Q16792           tumor rejection antigen 1 (TRA1); GP96 homolog;           94-kDa glucose-regulated protein (GRP94);       S72   endoplasmin   X15187; M33716   P14625       S73   uracil-DNAglycosylase (UNG1)   X15653   P13051       S74   NCK melanoma cytoplasmic src homolog (HSNCK)   X17576   P16333           5,6-dihydroxyindole-2-carboxylic acid oxidase           (DHICA oxidase); tyrosinase-related protein 1       S75   (TRP-1); catalase B; glycoprotein-75 (GP75)   X51420   P17643       S76   uracil-DNA glycosylase 2 (UNG2)   X52486   P22674           T-complex protein 1 alpha subunit (TCP1-alpha);       S77   COT-alpha (COTA; COT1)   X52882   P17987; Q15556       S78   40S ribosomal protein S3 (RPS3) X55715   P23396           DNA-(apurinic or apyrimidinic site) lyase; AP           endonuclease 1 (APE1); apurinic/apyrimidinic           endonuclease (APEX); APEX nuclease (APEN);       S79   REF1   X59764; X66133   P27695; Q99775       S8   heme oxygenase 2 (H02; HMOX2)   D21243; S34389   P30519; O60605           collagen-binding protein 1 (CBP1); CBP2; colligin 1;       S80   colligin 2; heat shock 47-kDa protein (HSP47)   X61598; D83174   P29043; P50454           T-complex protein 1 gamma subunit (TCP1-       S82   gamma); OCT-gamma (CCTG; CCT3); TR10S   X74801; U17104   P49368           DNA damage repair &amp; recombination protein 54       S83   homolog (RAD54)   X97795   Q92698           transcription factor IIH (TFIIH); 52-kDa basic       S84   transcription factor 2 subunit (BTF2p52)   Y07595   Q92759           X-ray repair-complementing defective repair in       S85   Chinese hamster cells 2 (XRCC2)   Y08837   O43543                   O15527; O00390;           8-oxyguanine DNA glycosylase 1 (OGG1); mutM   P78554; O00670;       S86   homolog (MMH)   Y11838   O00705; O14876       S87   cytochrome P450 1A2 (CYPIA2)   Z00036   P05177; Q16754           basic transcription factor 2 34-kDa subunit       S88   (BTF2p34)   Z30093   Q13889           N-oxide forming dimethylaniline monooxygenase 5;           hepatic flavin-containing monooxygenase 5       S89   (FMO5); dimethylaniline oxidase 5   L37080   P49326       S9   ubiquitin-like protein NEDD8   D23662   Q15843           multidrug resistance protein 3 (MDR3); P-       S91   glycoprotein 3 (PGY3)   M23234   P21439           N-oxide forming dimethylaniline monooxygenase 1;           hepatic flavin-containing monooxygenase 1       S92   (FM01); dimethylaniline oxidase 1   M64082   Q01740           ubiquitin-conjugating enzyme E2B (UBE2B);           ubiquitin-protein ligase; ubiquitin carrier protein;       S93   HR6B   M74525   P23567           p59 protein; HSP-binding immunophilin (HB1);           possible peptidyl-prolyl cis-trans isomerase           (PPlase); rotamase; 52-kDa FK506-binding protein       S95   (FKBP52); FKBP59; HSP56; FKBP4   M88279   Q02790           heat shock protein 40 homolog (HSP40 homolog);       S96   DNAJW   U40992   Q9UDY4           51-kDa FK506-binding protein (FKBP51); peptidyl-           prolyl cis-trans isomerase (PPlase); rotamase; 54-           kDa progesterone receptor-associated           immunophilin; FKBP54; FF1 antigen; HSP90-       S97   binding immunophilin   U42031   Q13451       S98   hematopoietic progenitor kinase (HPK1)   U66464   Q92918       S99   SPS1/Ste20 homolog KHS1   U77129   none           a disintegrin &amp; metalloproteinase domain 12       SK013   (ADAM12); meltrin-S   AF023477   O60470       SK029   plasma glutathione peroxidase (GPXP; GPX3)   D00632; X58295   P22352                   M16650; X55362;       SK035   ornithine decarboxylase (ODC1)   M20372   P11926       SK052   matrix gla-protein (MGP)   X07362   P08493           melanoma-derived growth regulatory protein;       SK054   melanoma inhibitory activity (MIA)   X84707   Q16674           cystatin B (CSTB); liver thiol proteinase inhibitor       SK062   (OPIB); stefin B   L03558   P04080           chaperonin-containing T-complex polypeptide 1           beta subunit (COT-beta; CCTB; CCT2; TCP1-       ST005   beta); 9908.1   AF026293   P78371           T-complex protein 1 zeta-like subunit (OCT-zeta-           like; TCP1-zeta-like); TSA303; testis-specific       ST015   TCP20   D78333   Q92526           thioredoxin (TROX; TXN); ATL-derived factor           (ADF); surface-associated sulphydrylprotein       ST018   (SASP)   J04026   P10599       ST027   mitochondrial uncoupling protein 3 (UCP3) AF011449   P55916; O60475           gamma-glutamyl hydrolase (GGH; GH);           folylpolygammaglutamyl hydrolase; gamma-glu-X       ST038   carboxypeptidase; conjugase   U55206   Q92820       ST040   farnesol receptor HRR-1   U68233   Q92943       ST042   mitochondrial uncoupling protein 2 (UCP2); UCPH   U82819   P55851           phosphoglyceride kinase 1 (PGKI; PGKA); primer       ST046   recognition protein 2 (PRP2)   V00572   P00558       ST051   tyrosine protein kinase receptor UFO   X66029   none           peptidylprolyl cis-trans isomerase A (PPlase; PPIA);           rotamase; cyclophilin A (CYPA); cyclosporin A-       ST057   binding protein Y00052 P05092           muscle-specific carbonic anhydrase III (CA3);       ST065 carbonate dehydratase III   M29458   P07451           soluble glutamic oxaloacetic transaminase 1           (GOT1): cytoplasmic aspartate aminotransferase 1;       ST066   transaminase A   M37400   P17174           acyl-CoA dehydrogenase long chain-specific       ST069   subunit (LCAD; ACADL)   M74096   P28330       ST075   ribosomal protein S29 (RPS29)   U14973   P30054           p53-induced gene 8 (PIG8); etoposide-induced       ST076   mRNA; E124   AF010313   O14681           eukaryotic translation initiation factor 4 gamma 3       ST077   (EIF4G3)   AF012072   O43432       ST078   glutathione S-transferase alpha 4 (GSTA4)   AF025887   O15217           mitogen-activated protein kinase kinase kinase 1           (MAPKKKI; MAP3K1); MAPK/ERK kinase kinase 1       ST079   (MEK kinase 1; MEKK1)   AF042838   Q13233       ST080   somatostatin (SST)   J00306   P01166           solute carrier family 3 member 2 (SLC3A2); antigen           identified by monoclonal antibodies 4F2, TRA1.10,       ST081   TROP4 &amp;T43; NACAE; MDU1; CD98 antigen   J02769   P08195; Q13543           collagen VII alpha 1 subunit (COL7A1); dystrophic           dominant &amp; recessive epidermolysis bullosa protein       Q02388; Q14054;       ST082   (EBDCT)   L02870   Q16507       ST083   core-binding factor beta subunit (CBFB); PEBP2B   L20298   Q13951; Q13124           guanine nucleotide binding protein-like 1 (GNL1);       ST084   HSR1   L25665   P36915           chaperonin containing TCPI subunit 6A (CCT6A);           CCT-zeta 1 (CCTZ); TCP20; histidine transport       ST085   regulator 3 (HTR3)   L27706   P40227           coagulation factor VII (F7); serum prothrombin       ST086   conversion accelerator   M13232   P08709           gamma-glutamyltransferase 1 (GGT 1); glutamyl       ST087   transpeptidase   M24903   P19440                   P01236; Q15199;       ST088   prolactin (PRL)   V00566   Q92996           major histocompatibility complex class II DN alpha       ST089   (HLA-DNA); HLA-DOA; HLA-DZA   M31525   P06340       ST091   even-skipped homeobox protein 2 homolog (EVX2)   M59982   Q03828           carcinoembryonic antigen-related cell adhesion       ST092   molecule 1 (CEACAM1); biliary glycoprotein (BGP)   S71326   Q16170           GATA-binding protein 1 (GATA1); globin           transcription factor 1 (GF1); erythroid transcription       ST093   factor 1 (ERYF1)   X17254   P15976           granzyme B (GZMB); granzyme 2; cytotoxic T-           lymphocyte-associated serine esterase 1 (CTLA1);           fragmentin 2; cathepsin G-like protein 1 (CGL1);       ST094   CSPB   M17016; M38193   P10144       ST095   cardiac-specific homeobox protein (CSX); NKX2-5   U34962   P52952           myeloid/lymphoid leukemia translocated to 10           homolog (MLLT 10); mixed-lineage leukemia           translocated to 10 homolog; ALLi fused gene from       ST096   chromosome 10(AF10)   U13948   P55197           cyclin-dependent kinase inhibitor 1B (CDKN1B);       ST099   CDKN4; p27KlP1   U10906   P46527; Q16307       ST100   ankyrin 3 node of Ranvier (ANK3); ankyrin G   U13616   Q12955                   L78833; U14680;       ST101   early-onset breast cancer protein 1 (BRCA1)   U37574   P38398           cyclin-dependent kinase inhibitor 2C (CDKN2C);       ST102   p18INK4C   AF041248   P42773           fas-associated via death domain protein (FADD);           mediator of receptor-induced toxicity protein I       ST103   (MORT1)   U24231   Q13158; Q14866           growth factor-independent protein 1 (GFII);       ST104   ZNF163   U67369   Q99684           karyopherin beta 2 (KPNB2); importin beta 2;       Q92973; Q92957;       ST105   transportin (TRN); M9-interacting protein (MIP)   U70322   Q92975           telomerase-associated protein 1 (TP1); telomerase       ST106   protein component 1 (TEP1)   U86136   Q99973           pentraxin 3 (PTX3); pentaxin-related gene rapidly       ST108   induced by IL1-beta   X63613   P26022           neuronal DNAJ-like heat shock protein 1 (HSJ1);       ST109   40-kDa heat shock protein 3 (HSPF3)   X63368   P25686           dual specificity phosphatase 1 (DUSP1); CL100;           PTPN10; HVHI; MAP kinase phosphatase 1       ST110   (MKP1)   U01669; X68277   P28562                   Q15853; Q15852;           fos-interacting upstream stimulatory factor 2   Q00671; Q00709;       ST111   (USF2); FIP   Y07661   Q05750; Q07952           insulin promoter factor 1 (IPF1); islet/duodenum           homeobox protein 1 (IDX1); somatostatin           transcription factor 1 (STF1); maturity-onset       ST112   diabetes of the young protein IV (MODY4);   X99894   P52945; Q60594           pancreas/duodenum homeobox protein 1 (PDX1)       ST113   inhibitor of DNA-binding protein 4 (ID4)   U28368   P47928; Q13005       51114   thrombospondin 4 (THBS4)   Z19585   P35443       ST115   cyclin F (CCNF)   Z36714   P41002           63-kDa FK506-binding protein 9 (FKBP9); FKBP63;       ST117   FKBP60   AF089745   Q95302       ST118   FK506-binding protein   AF092137   Q9Y6B0           peroxisomal biogenesis factor 11 alpha (PEX11-       ST119   alpha; PEXiIA)   AF093668   Q75192           cysteine desulfurase; nitrogen-fixing bacteria S       ST120   homolog (N1FS)   AF097025   Q9Y697           cathelicidin antimicrobial peptide (CAMP); FALL39;       ST121   CAP18   Z38026   P49913       ST122   caspase 14 (CASP14); MICE   AF097874   Q95823       ST123   timeless homolog (TIM)   AF098162   Q9UNS1       ST124   period homolog 2 (PER2)   AB002345   Q15055       ST125   BTB &amp; CNC homology protein 1 (BACH1)   AB002803   Q14867; Q43285           sex-determining region Y box-containing gene 20       ST126   (SRY box-containing gene 20; SOX20)   AB006867 Q60248           heat shock transcription factor 2-binding protein       ST127   (HSF2BP)   AB007131   Q75031           transforming growth factor beta 1-induced transcript       ST128   1 (TGFBII1); HICS; ARA55; TSC5   AB007836   Q43294       ST130   KIAA0516   AB011088   Q60271           DEAD/H (Asp-Glu-AIa-Aspf His) box polypeptide 16       ST131   (DDX16)   AB011149   Q60231; Q60322                   O75771; O60355;                   O43537; O76085;       ST132   RAD51-like protein 3 (RAD5IL3); TRAD   AF034956   Q75196; Q75847       ST133   aquaporin 8 (AQP8)   AB013456   Q94778       ST134   KIAA0700   AB014600   O75182           KIAA0709; macrophage mannose endocytic       ST135   receptor   AB014609   Q9UBG0       ST136   MRJ member of the DNAJ protein family   AB014888   Q75190; Q95806           adaptor-related protein complex 1 sigma 2 subunit           (AP1S2); clathrin adaptor complex 1 sigma lB       ST137   subunit   AB015320   none       ST139   KIAAI027; talin (TLN)   AB028950   Q9UPX3           phosphatidylethanolamine N-methyltransferase       ST140   (PEMT)   AB029821   Q9Y6V9       ST141   choline kinase-like protein (CHKL)   AB029886   Q9Y259; Q13388           degenerative spermatocyte homolog (DEGS);       ST142   membrane fatty acid (lipid) desaturase (MLD)   AF002668   Q15121           estrogen receptor-binding fragment-associated           gene 9 (EBAG9; EB9); receptor-binding cancer       ST143   antigen expressed on 5150 cells 1 (RCAS1)   AF006265 Q00559       ST144   outer dense fiber of sperm tails protein 2 (ODF2)   AF012549   Q14721       ST146   palmitoyl-protein thioesterase 2 (PPT2)   AF020544   Q14799           eukaryotic translation initiation factor 3 subunit 4       ST147   (EIF3S4); EIF3-delta   AF020833   Q75821; Q14801       ST148   DJ-1 RNA-binding protein regulatory subunit   AF021819   Q14805       ST149   period homolog 1 (PER1); RIGU1   AF022991   Q15534       ST150   deleted in liver cancer protein 1 (DLC1)   AF026219   Q14868           branched chain alpha-ketoacid dehydrogenase       ST151   kinase (BOKOK)   AF026548   Q14874       ST152   microsomal glutathione 5-transferase 3 (MGST3)   AF026977   Q14880       ST153   glypican 4 (GPC4)   AF030186   O75487; Q9UPD9           testis-enhanced gene transcript (TEGT); BAX       ST154   inhibitor 1 (BI1)   AF033095   P55061; Q14938       ST155   stromal cell-derived factor receptor 1 (SDFR1)   AF035287   Q9Y499       ST156   RING zinc finger protein 13 (RNF13; RZF)   AF037204   Q43567       ST157   voltage-dependent anion channel 3 (VDAC3)   AF038962   Q9Y277; Q9UISO       ST158   cell death-inducing OFFA-like effector A (CIDEA)   AF041378   O60543       ST1 59 unc51 -like kinase 1 homolog (ULK1)   AF045458   Q75385           ubiquitin-activating enzyme EIC (UBEIC); UBA3       ST160   homolog   AF046024   Q76088           amyloid beta A4 protein-binding family A member 2           (APBA2); X11-like protein (XIL); Munc18-1-       ST161   interacting protein 2 (MINT2)   AF047348   Q99767; Q60571       ST162   32-kDa thioredoxin-like protein (TXNL; TXL)   AF051896   Q43396       ST163   Sec6l-gamma (SEC61G)   AF054184   none           microsomal NAD+-dependent retinol       ST164   dehydrogenase 4 (RODH4)   AF057034   Q75452           serine protease 21 (PRSS2 1); testisin 1 (TEST1);       ST165   serine protease from eosinophils 1 (ESP1)   AF058300   Q9Y6M0           mitochondrial ribosomal protein SI 2 (RPMS12;       ST166   RPSM12)   AF058761   Q15235           ADP-forming succinate-CoA ligase beta subunit       ST167   (SUCLA2)   AF058953   Q95194       ST168   E2F transcription factor 6 (E2F6)   AF059292   Q75461; Q60544       ST169   UDP-glucose dehydrogenase (UDPGDH; UGDH)   AF061016   Q60701; Q60589           catenin delta 1 (CTNND 1); cadherin-associated src       ST170   substrate (GAS)   AF062333   Q60935           heart &amp; neural crest derivatives-expressed protein 1       ST171   (HAND1); THING1   AF061756   Q96004           clone 24651 (IMAGE Consortium human infant       ST172   brain library IN1B)   AF070648   none       ST173   SURF-4   AF078866   Q9UNZ1       ST174   growth factor-independent protein 1B (GFI1B)   AF081946   Q95270           D-type cyclin-interacting protein 1 (DIP1); GCIP;       ST175   MAID   AF082569   Q95273           thyroid receptor-1nteracting protein 15 (TRIP 15);       ST176   ALIEN; SGN2   AF084260   none           Housekeeping Genes           liver glyceraldehyde 3-phosphate dehydrogenase        16   (GAPDH; G3PDH)   X01677   P04406                   P02570; Q11211;                   P99021; Q64316;        49   cytoplasmic beta-actin (ACTB)   X00351   P70514       901   tubuiin alpha 1 (TUBA1)   K00558   P04687       902   major histocompatibility complex class 1 C (HLAC)   M11886   P10321           23-kDa highly basic protein; 60S ribosomal protein       903   L13A(RPL13A)   X56932   P40429       904   40S ribosomal protein 39 (RPS9)   U14971   P46781       905   ubiquitin C (UBC)   M26880   none           phospholipase A2; tyrosine 3-           monooxygenase/tryptophan 5-monooxygenase           activation protein zeta polypeptide (YWHAZ); 14-3-           3 protein zeta/delta; protein kinase C inhibitor           protein 1 (K01P1); factor activating exoenzyme S       906   (FAS)   M86400   P29312; P29213           hypoxanthine-guanine phosphoribosyltransferase 1       907   (HPRT1)   V00530   P00492                  
 
     EXAMPLE 3  
     Alternative Human Stress Array  
     [0069] An alternative array to that described in Examples 1 and 2 displays probes obtained from the list of genes appearing in Table 3, where these particular probes are displayed instead of or in addition to those described in Tables 1 and/or 2.  
                           TABLE 3                       Clon ID   Gene Name   Gen Bank Acc #   Sprot Acc #                      inducible nitric oxide synthase (INOS); type                10   II NOS; hepatocyte NOS (HEP-NOS)   L09210   P35228; Q16692           605 ribosomal protein L6 (RPL6); TAX-           responsive enhancer element binding           protein 107 (TAXREB107); neoplasm-       103   related protein C140   X69391   Q02878           activating transcription factor 4 (ATF4); tax-           responsive enhancer element B67           (TAXREB67); cAMP-response element-       145   binding protein 2 (CREB2)   D90209   P18848           platelet-derived growth factor B subunit           precursor (PDGFB; PDGF2); bacaplermin;   X02811; X02744;        15   c-sis   M12783; M16288   P01127; P78431           tumor necrosis factor receptor 1 (TNFR1);           tumor necrosis factor binding protein 1       155   (TBP1); CD120A antigen   M33294   P19438           hepatocyte growth factor activator (HGF       167   activator)   D14012   Q04756; Q14726           interleukin-1 alpha precursor (IL-1 alpha;        18   IL1A); hematopoietin-1   X02851   P01583           glial growth factor 2 precursor           (GGFHPP2); neuregulin; heregulin-beta3 +   L12260; L12261 +   Q07110; Q07111 +       183   neu differentiation factor + heregulin-alpha   U02326 + M94165   Q12780 + Q02297           T-cell-specific rantes protein precursor; sis           delta; small inducible cytokine A5 (SCYA5);       195   rantes pro-inflammatory cytokine   M21121   P13501           interferon gamma precursor (IFN-gamma;        2   IFNG); immune interferon   X01992; M29383   P01579       206   oncostatin M (OSM)   M27288   P13725           interleukin-4 precursor (IL-4); B-cell           stimulatory factor 1 (BSF-1); lymphocyte        21   stimulatory factor 1   M13982   P05112           interleukin-6 precursor (IL-6); B-cell           stimulatory factor 2 (BSF2); interferon beta-        22   2 (IFNB2); hybridoma growth factor   X04602; M14584   P05231           hepatocyte growth factor (HGF); scatter       226   factor (SF); hepatopoeitin A   M60718   P14210           tumor necrosis factor alpha precursor        23   (TNF-alpha; TNFA); cachectin   X01394   P01375           interleukin-12 beta subunit precursor (IL-           12B); cytotoxic lymphocyte maturation           factor 40-kDa subunit (CLMF p40); NK cell       237   stimulatory factor subunit 2 (NKSF2)   M65290   P29460           interleukin-12 alpha subunit precursor (IL-           12A); cytotoxic lymphocyte maturation           factor 35-kDa subunit (CLMF p35); NK cell       238   stimulatory factor subunit 1 (NKSF1)   M65291   P29459           fasL receptor; apoptosis-mediating surface       239   antigen fas; APO-1 antigen; CD95 antigen   M67454   P25445           lymphotoxin-alpha precursor (LT-alpha);           tumor necrosis factor-beta (TNF-beta;        24   TNFB)   D12614   P01374           interferon gamma-induced protein       273   precursor (gamma-IP10)   X02530   P02778           interleukin-5 precursor (IL-5); T-cell           replacing factor (TRF); eosinophil           differentiation factor; B-cell differentiation        28   factor I   X04688; J03478   P05113           macrophage inflammatory protein 2 alpha           (MIP2-alpha); growth-regulated protein beta       288   (GRO-beta)   X53799   P19875           OX40 ligand (OX40L); GP34; tax-           transcriptionally activated glycoprotein 1       298   (TXGP1)   X79929   P23510           granulocyte-macrophage colony stimulating        31   factor (GM-CSF); CSF2   M11220   P04141           integrin alpha 9 (ITGA9); integrin alpha-       318   RLC   D25303; L24158   Q13797; Q14638           intercellular adhesion molecule 1 precursor           (ICAM1); major group rhinovirus receptor;       329   CD54 antigen   J03132   P05362           transforming growth factor-beta 3 (TGF-       330   beta3)   J03241   P10600           natural killer cell enhancing factor (NKEFB) +           thiol-specific antioxidant protein (TSA);           thioredoxin peroxidase 1 (TDPX1);           thioredoxin-dependent peroxide reductase   L19185 + Z22548;   P32119; P35701       362   1   X82321   P31945; Q92763           protein serine/threonine kinase STK1; cell           division protein kinase 7 (CDK7); CDK-           activating kinase (CAK); 39-kDa protein       366   kinase   L20320   P50613       373   apoptosis regulator bax   L22474   Q07814           placental plasminogen activator inhibitor 2           (PAI-2; PLANH2); monocyte ARG-serpin;       396   urokinase inhibitor   M18082; J02685   P05120       408   ras-related protein RAB5A   M28215   P20339           epidermal growth factor precursor (EGF);        41   beta-urogastrone   X04571   P01133           E-selectin precursor (SELE); endothelial           leukocyte adhesion molecule 1 (ELAM1);           leukocyte-endothelial cell adhesion       416   molecule 2 (LECAM2); CD62E antigen   M30640   P16581           NADH-ubiquinone dehydrogenase 1 beta           subcomplex 7 18-kDa subunit (NDUFB7);           complex I-B18 (CI-B18); cell adhesion       425   protein SQM1   M33374   P17568           interleukin-10 precursor (IL-10); cytokine        43   synthesis inhibitory factor (CSIF)   M57627   P22301           octamer-binding transcription factor 2 (oct-           2; OTF2); lymphoid-restricted           immunoglobulin octamer binding protein       435   NF-A2; POU2F2   M36542   P09086           transcriptional enhancer factor (TEF1);           protein GT-IIC; transcription factor 13       462   (TCF13)   M63896   P28347           ubiquitin-conjugating enzyme E2 17-kDa           (UBE2A); ubiquitin-protein ligase; ubiquitin       468   carrier protein; HR6A   M74524   P49459       483   40S ribosomal protein S19 (RPS19)   M81757   P39019           peroxisome assembly factor 1 (PAF1);           peroxisomal membrane protein 3 (PXMP3;           PMP3); 35-kDa peroxisomal membrane       490   protein (PMP35); peroxin 2 (PEX2)   M86852   P28328       532   amphiphysin (AMPH)   U07616   P49418        59   erythropoietin receptor (EPOR)   M60459   P19235        6   interleukin-2 precursor (IL-2); T-cell growth   A14844   P01585           factor (TCGF)           5-hydroxytryptamine 1D receptor (5-HT-1D;       624   HTR1D); serotonin receptor   M89955   P28221           cyclin-dependent protein kinase 2 (CDK2);       632   p33 protein kinase   M68520   P24941           colorectal cancer suppressor protein       665   precursor (DCC)   X76132   P43146           fibronectin receptor alpha subunit (FNRA);           integrin alpha 5 (ITGA5); VLA5; CD49E       687   antigen   X06256   P08648           integrin alpha L (ITGAL); leukocyte           adhesion glycoprotein alpha subunit           precursor; leukocyte function-associated           molecule 1 alpha chain (LFA1); CD11A       693   antigen   Y00796   P20701           fas antigen ligand (FASL); apoptosis       694   antigen ligand (APTL; APT1LG1); TNFSF6   D38122; U08137   P48023       712   L-myc proto-oncogene (MYCL1)   M19720   P12524       726   transcription factor relB; I-rel   M83221   Q01201       759   fos-related antigen (FRA1); fosL1   X16707   P15407       763   vimentin (VIM)   X56134; M14144   P08670           tumor necrosis factor receptor 1-associated           death domain protein (TNFR1-associated       781   death domain protein; TRADD)   L41690   Q15628       782   apoptosis regulator bcl-2   M14745   P10415           TNF-related apoptosis inducing ligand       797   (TRAIL); APO-2 ligand (APO2L)   U57059   P50591        85   DNA-binding protein inhibitor ld-2   M97796   Q02363           CDC25B; CDC25HU2; M-phase inducer       878   phosphatase 2   M81934; S78187   P30305           cyclin-dependent kinase 4 inhibitor 2B           (CDKN2B); p14-INK4B; multiple tumor       879   suppressor 2 (MTS2)   U17075; L36844   P42772           triiodothyronine receptor; thyroid hormone           receptor (THRA1); v-erbA-related protein        97   ear-1   M24898   P20393       AF104419   decoy receptor 3 (DCR3)   AF104419   O95407       B121   dihydrofolate reductase (DHFR)   V00507   Q14130; P00374       B122   thymidylate synthase (TYMS; TS)   X02308   P04818           octamer-binding transcription factor 1 (oct-           1; OTF1); octamer binding protein NF-A1;       B132   POU2F1   X13403   P14859           zinc finger protein 40 (ZNF40); human           immunodeficiency virus type I enhancer-           binding protein 1 (HIV-EP1); major           histocompatibility complex binding protein 1           (MBP-1); positive regulatory domain II       B138   binding factor I (PRDII-BF1)   X51435   P15822           major vault protein (MVP); lung resistance-       B164   related protein (LRP)   X79882   Q14764           nervous-system specific octamer-binding           transcription factor N-oct3; N-oct5A &amp; N-           oct5B; brain-specific homeobox/POU       B179   domain protein 2 (POU3F2); brn2; oct7   Z11933   Q14960; P20265           B-lymphocyte kinase; tyrosine-protein       B188   kinase BLK; p55-BLK   Z33998   P51451       B25   cytosolic thymidine kinase (TK1)   K02581   P04183           plasma-cell membrane glycoprotein PC-1;           alkaline phosphodiesterase I; nucleotide       B70   pyrophosphatase (NPPase)   M57736   P22413           matrix metalloproteinase 14 precursor           (MMP14); MMP-X1; membrane-type matrix       C121   metalloproteinase 1 (MT-MMP1)   D26512; X83535   P50281; Q92678           cadherin 6 precursor (CDH6); kidney       C122   cadherin (K-cadherin)   D31784   P55285           cadherin 11 precursor (CDH11); osteoblast-       C141   cadherin (OB-cadherin); OSF4   L34056   P55287; Q15065           cadherin 12 (CDH12); brain cadherin           precursor (Br-cadherin); neural cadherin 2       C142   (N-cadherin 2)   L34057; L33477   P55289           cadherin 13 (CDH13); truncated cadherin           precursor (T-cadherin); heart cadherin (H-   L34058; U59289;       C143   cadherin)   U59288   P55290           cell division protein kinase 4; cyclin-       C149   dependent kinase 4 (CDK4); PSK-J3   M14505   P11802; O00576           cell division protein kinase 5 (CDK5); tau           protein kinase II catalytic subunit (TPKII           catalytic subunit); serine/threonine protein       C201   kinase PSSALRE   X66364   Q00535       C236   c-myc binding protein MM-1   D89667   Q99471       C288   sonic hedgehog (SHH)   L38518   Q15465           growth inhibitory factor (GIF);       C3   metallothionein-III (MT-III; MT3)   D13365; M93311   P25713       C359   CD27BP (Siva)   U82938   O15304       C369   apoptosis inhibitor survivin   U75285   O15392           interleukin-1 receptor antagonist protein       C38   precursor (IL-1RA; IRAP)   M63099   P18510       C41   G1/S-specific cyclin C   M74091   P24863           serine/threonine-protein kinase PLK1       C53   (STPK13)   U01038   P53350           met proto-oncogene; hepatocyte growth           factor receptor precursor (HGF-SF       C7   receptor)   J02958   P08581       C79   CDC37 homolog   U63131   Q16543           tissue inhibitor of metalloproteinase 1           precursor (TIMP1); erythroid potentiating       C83   activity (EPA); fibroblast collagenase   X03124   P01033; Q14252           inhibitor           retinoic acid receptor alpha; retinoid X       C92   receptor alpha (RXRA)   X52773   P19793           matrix metalloproteinase 11 (MMP11);       C95   stromelysin 3   X57766   P24347       CA033   macrophage inhibitory cytokine 1 (MIC1)   AF019770   Q99988       CA061   RecQ protein-like (DNA helicase Q1-like)   D37984   P46063       CA079   calmegin   D86322   O14967           ribosomal protein S6 kinase II alpha 1           (S6KII-alpha 1); ribosomal S6 kinase 1       CA102   (RSK1)   L07597   Q15418           major histocompatibility complex enhancer-       CA169   binding protein MAD3   M69043   P25963           hypoxia-inducible factor 1 alpha (HIF1           alpha); ARNT-interacting protein; member       CA219   of PAS protein 1 (MOP1)   U22431   Q16665       CA260   DNA-binding protein UEV-1; UBE2V   U49278   Q13532       CA270   cell cycle protein P38-2G4 homolog; HG4-1   U59435   O43846       CA280   JV18-1. HMAD-2 OR MADR2 OR SMAD2   U68018   Q15796       CA282   box-dependent myc-interacting protein 1   U68485   Q92944       CA283   fuse-binding protein 2 (FBP2)   U69126   Q92945           btg protein precursor; NGF-inducible anti-       CA287   proliferative protein PC3   U72649   P78543           sentrin; ubiquitin-like protein SMT3C;           ubiquitin-homology domain protein PIC1;           UBL1; SUMO-1; GAP modifying protein 1;       CA295   GMP1   U83117   Q93068       CA359   L-lactate dehydrogenase H subunit (LDHB)   Y00711   P07195       CA388   methyl CpG-binding protein 2 (MECP2)   L37298   P51608; O15233           GLCLC, GLCL (Glutamate-cysteine ligase           catalytic subunit, gamma-glutamylcysteine       CA396   synthetase)   M90656   P48506           methallothionein IH (MT1H);       P80294 + P02795 +           metallothinein0 (MT0) + MT1I; MT2 + MT1L +   X64177 + X97260 +   P80297 +       CA410   MT1R   X76717 + X97261   Q93083       CA421   checkpoint kinase 1 (CHK1)   AF016582   O14757       CA458   erythropoietin   M11319   P01588           AP4 basic helix-loop-helix DNA-binding       CA466   protein   S73885   Q01664       CA467   fatty acid synthase   S80437   Q13479           H-ras proto-oncogene; transforming G       CA514   protein   V00574   P01112       CA517   ornithine decarboxylase   X16277   P11926       CA527   high mobility group protein HMG2   X62534   P26583           aurora- &amp; IPL1-like midbody-associated       CA552   protein kinase 1 (AIM1); ARK2   AF008552   O60446       E026   RCL growth-related c-myc-responsive gene   AF040105   O43598           putative renal organic anion transporter 1       E044   (hROAT1)   AF057039   O95187       E050   cyclin K   AF060515   O75909               AF039067;       E061   IEX-1L anti-death protein; PRG-1; DIF-2   AF071596   O75353       E084   pancreatitis-associated protein 1 precursor   D13510   Q06141       E091   proteasome activator HPA28 subunit beta   D45248   Q15129       E097   thiosulfate sulfurtransferase; rhodanese   D87292   Q16762       E099   cyclin G-associated kinase (GAK)   D88435   O14976       E105   alpha-1-antichymotrypsin precursor (ACT)   K01500   P01011           neutral amino acid transporter A (SATT);           alanine/serine/cysteine/threonine       E112   transporter (ASCT1)   L14595   P43007       E114   monocarboxylate transporter 1 (MCT1)   L31801   P53985       E122   neuromedin B precursor   M21551   P08949           cystic fibrosis transmembrane conductance           regulator (CFTR); cAMP-dependent       E124   chloride channel   M28668   P13569       E127   deoxyribonuclease I (DNase I)   M55983   P24855           canalicular multispecific organic anion           transporter; multidrug resistance-           associated protein 2 (MRP2); canalicular       E166   multidrug resistance protein   U63970   Q92887           alpha-1-antitrypsin precursor; alpha-1       E179   protease inhibitor; alpha-1-antiproteinase   X02920   P01009           hepatocyte nuclear factor 4 (HNF4);       E195   transcription factor 14   X76930   P41235       E197   metal-regulatory transcription factor   X78710   Q14872           chloride conductance regulatory protein           ICLN; nucleotide-sensitive chloride channel           1A; chloride ion current inducer protein       E200   (CLCI); reticulocyte PICLN   X91788   P54105           eosinophil granule major basic protein           precursor (MBP); pregnancy-associated           major basic protein; bone marrow       E204   proteoglycan 2   Y00809   P13727           dual-specificity protein phosphatase 9;           mitogen-activated protein kinase           phosphatase 4 (MAP kinase phosphatase 4       E207   (MKP4)   Y08302   Q99956           CCAAT/enhancer binding protein alpha       E226   (C/EBP alpha)   U34070   P49715           NAD(P)H dehydrogenase; quinone           reductase; DT-diaphorase; azoreductase;           phylloquinone reductase; menadione       E240   reductase   J03934   P15559       H028   apolipoprotein A-II precursor (APOAII)   X00955   P02652       H029   apolipoprotein C-III precursor (APOCIII)   X01388   P02656       H031   hepatic triglyceride lipase (HTGL)   X07228   P78529; P11150       H044   NADPH-cytochrome p450 reductase   S90469   Q16455; P16435       H046   adrenodoxin   M34788   P10109           tissue inhibitor of metalloproteinase 2       H054   precursor (TIMP2)   J05593   P16035       H063   matrix metalloproteinase 15 (MMP15)   Z48482   P51511       H065   matrix metalloproteinase 14 (MMP14)   D26512   P50281       H072   matrix metalloproteinase 1 (MMP1)   X54925   P03956           ileal sodium-dependent bile acid transporter           (ISBT); ileal sodium/taurocholate           cotransporting polypeptide (NTCP2);       H091   SLC10A2   U10417   Q12908; Q13839           alcohol dehydrogenase alpha subunit +           alcohol dehydrogenase 2 + alcohol   M12271 + D00137 +   P07327 + P00325 +       H093   dehydrogenase 3   X04299   P00326       H102   bile-salt-activated lipase   M85201; M37044   P19835           alcohol dehydrogenase 6 + aldehyde       H117   dehydrogenase 1 (ALDH1)   K03000   P28332 + P00352       H130   vascular cell adhesion protein 1   X53051   P19320           macrophage colony stimulating factor 1       H138   (CSF1; MCSF)   M37435   P09603       H147   estradiol 17 beta-dehydrogenase 1   M36263   P14061           intestinal fatty acid-binding protein 2           (FABP2; IFABP) + liver fatty acid-binding       H151   protein 1 (FABP1; LFABP)   M10050 + M10617   P12104 + P07148       H163   corticosteroid-binding globulin   J02943   P08185           sodium-dependent bile acid cotransporter;           hepatic sodium/taurocholate cotransporting       H165   polypeptide (NTCP); SLC10A1   L21893   Q14973               X51473; X02415       H188   fibrinogen G gamma polypeptide   K02569   P02679       H270   endothelin-converting enzyme 1   Z35307   P42892           mitochondrial enoyl-CoA hydratase short       H273   subunit 1   D13900   P30084; O00739       H275   peroxisomal bifunctonal enzyme   L07077   Q08426       H277   orphan nuclear hormone receptor BD73   L31785   Q14995           very-long-chain-specific acyl-CoA       H307   dehydrogenase precursor (VLCAD)   D43682   P49748           familial intrahepatic cholestasis 1 protein       H339   (FIC1)   AF038007   O43520           peroxisomal acyl-CoA oxidase branched       H344   subunit (BRCOX)   X95190   Q99424           sodium-independent organic anion           transporter; organic anion transporting       H361   polypeptide (OATP); SLC21A3   U21943   P46721       H365   cytochrome P450 IB1 (CYP1B1)   U03688   Q16678; Q93089           cytochrome P450 IIA6 (CYP2A6) +   M33318; M33316 +   P11509 + P20853 +       H366   CYP2A7 + CYP2A13 + CYP2A7PT +   U22029 + U22030 +   Q16696           CYP2A7PC   U22044                   P05184 + P08684 +           cytochrome P450 IIIA3 (CYP3A3) +   M13785 + M18907 +   P20815 +       H373   CYP3A4 + CYP3A5 + CYP3A7   J04813 + D00408   P24462       H377   cytochrome P450 VA1 (CYPSA1)   M80647   P24557       H378   cytochrome P450 VIIA1 (CYP7A1)   X56088   P22680       H382   cytochrome P450 XVIIA1 (CYP17A1)   M14564   P05093           peroxisomal 3-ketoacyl-CoA thiolase           precursor (PTHIO); peroxisomal 3-oxoacyl-           CoA thiolase; beta-ketothiolase; acetyl-CoA       H389   acyltransferase (ACAA)   X14813   P09110           low-density lipoprotein receptor (LDL       H395   receptor; LDLR)   M28219   P01130           prostaglandin-endoperoxide synthase 1           precursor; prostaglandin G/H synthase 1           (PGH synthase 1; PTGS1; PHS1);       H416   cyclooxygenase 1 (COX1)   M59979   Q15122; P23219           prostaglandin G/H synthase 2 precursor           (PGH synthase 2; PGHS2; PTGS2);           cyclooxygenase 2 (COX2); prostaglandin-       H418   endoperoxide synthase 2   M90100   P35354; Q16876           3-hydroxy-3-methylglutaryl-coenzyme A       N087   reductase (HMG-CoA reductase; HMGCR)   M11058   P04035           major prion protein precursor (PRP);       N094   PRP27-30; PRP33-35C; ASCR   M13667   P04156       N097   lipoprotein lipase precursor (LPL)   M15856   P06858           lung group IB phospholipase A2 precursor           (PLA2); phosphatidylcholine 2-       N102   acylhydrolase   M21054   P04054           protein phosphatase 2B regulatory subunit;       N113   calcineurin B subunit isoform 1   M30773   P06705           lipopolysaccharide-binding protein       P18428; Q92672;       N119   precursor (LBP)   M35533   O43438           protein-tyrosine phosphatase MEG2       N144   (PTPASE-MEG2)   M83738   P43378           sodium- &amp; chloride-dependent glycine       N158   transporter 1 (GLYT-1)   S70609   P48067           peroxisome assembly factor-2 (PAF-2);           peroxisomal-type ATPase 1; peroxin-6;       N235   PEX6; PXAAA1   U56602   Q13608; Q99476           protein-tyrosine phosphatase PTEN;           mutated in multiple advanced cancers 1       N253   (MMAC1); TEP1   U92436   O00633; O02679           calbindin; avian-type vitamin D-dependent       N260   calcium binding protein (CABP); D-28K   X06661   P05937           D-amino acid oxidase (DAMOX; DAO;       N265   DAAO)   X13227   P14920; Q16758           dopamine beta-hydroxylase (DBH);       N266   dopamine-beta-monooxygenase precursor   X13255   P09172           laminin alpha 1 subunit precursor (LAMA1);       N285   laminin A chain   X58531   P25391           mitochondrial aldehyde dehydrogenase       N347   precursor (class 2); ALDHI; ALDH2   Y00109   P05091; Q03639       N395   CREATINE KINASE B CHAIN   L47647   P12277           protein-tyrosine phosphatase alpha       N400   precursor (R-PTP-alpha; PTPRA; PTPA)   M34668   P18433           activin receptor type II precursor (ACTRIIA;       P021   ACVR2)   D31770   P27037;; Q92474           GAP JUNCTION ALPHA-5 PROTEIN       P035   (CONNEXIN 40) (CX40)   L34954   P36382       P039   INVOLUCRIN   M13903   P07476           CELLULAR RETINOIC ACID BINDING       P055   PROTEIN   S74445   P29762           RETINOID X RECEPTOR GAMMA (RXR-       P075   GAMMA)   U38480   P48443           GAP JUNCTION BETA-1 PROTEIN           (CONNEXIN 32) (CX32) (LIVER GAP       P125   JUNCTION PROTEIN)   X04325   P08034       SK032   complement 3 (C3)   K02765   P01024           polyspecific organic cation transporter N1       ST002   (OCTN1)   AB007448   O14546       ST003   peroxisomal membrane protein 69 (PMP69)   AF009746   O14678           peroxisome biogenesis disorder protein 1       ST004   (PEX1)   AF026086   O43933       ST006   TNF-alpha-stimulated ABC protein (TSAP)   AF027302   O14897           organic cation transporter-like protein 2       ST007   (ORCTL2)   AF037064   O43562       ST008   organic cation transporter N2 (OCTN2)   AF057164   O76082       ST009   sulfonylurea receptor 2A (SUR2A)   AF061323   O60706       ST111   MRP/organic anion transporter (MOAT-B)   AF071202   Q9Y6J2           adrenoleukodystrophy-related protein       ST012   (ALDR)   AJ000327   none           glutamic-pyruvate transaminase 1 (GPT1);       P24298; P78398;       ST014   alanine aminotransferase 1 (AAT1)   D10355   Q93076           vascular endothelial growth factor D           (VEGFD); C-FOS-induced growth factor       ST016   (FIGF)   D89630   O43915           skeletal muscle adenine nucleotide           translocator 1 (ANT1); heart/skeletal           muscle ADP/ATP carrier protein isoform       ST017   T1; ADP/ATP translocase 1   J02966   P12235       ST019   down-regulated in adenoma protein (DRA)   L02785   P40879           sulfonylurea receptor (SUR); ATP-binding           cassette subfamily C (CFTR/MRP) member       ST023   8 (ABCC8)   L78207   Q09428           enolase 1 alpha (ENO1); non-neural       ST024   enolase (NNE); phosphopyruvate   M14328   P06733           hydratase (PPH)           mitochondrial glutamic oxaloacetic           transaminase 2 (GOT2); aspartate       ST025   aminotransferase 2; transaminase A   M22632   P00505                   P02735; P02736;       ST026   serum amyloid A1 precursor (SAA1)   M23698   P02737           complement component 4-binding protein           alpha (C4B-binding protein; C4BPA);       ST028   proline-rich protein (PRP)   M31452   P04003           mitochondrial carnitine palmitoyltransferase       ST029   II precursor (CPTase; CPT2)   M58581   P23786           zinc finger protein 37 (ZFP37); KRAB       ST030   domain zinc finger protein   AF022158   Q9Y6Q3           mitochondrial brown fat uncoupling protein       ST034   1 (UCP1)   U28480   P25874; Q13218           biliverdin reductase A precursor (BLVRA;       ST035   BVR)   U34877   P53004           CCAAT/enhancer-binding protein epsilon       ST037   (C/EBP epsilon; CEBPE)   U48866; U48865   Q15744; Q15745           prostaglandin transporter (PGT); solute       ST041   carrier family 21 member 2 (SLC21A2)   U70867   Q92959       ST044   ATP-binding cassette transporter (ABCR)   U88667   P78363           glucose-6-phosphate dehydrogenase       ST047   (G6PD)   X03674   P11413; Q16765           tyrosine aminotransferase (TAT); I-       ST048   tyrosine:2-oxoglutarateaminotransferase   X52520   P17735       ST049   bile salt export pump (BSEP)   AF091582   O95342       ST052   RNase L inhibitor   X76388   Q13181; Q13864           mitochondrial phosphoenolpyruvate           carboxykinase 2 precursor (PEPCK-M;       ST053   PCK2); phosphoenolpyruvate carboxylase   X92720   Q16822; O43253           anthracycline resistance-associated protein       ST054   (ARA)   X95715   Q13798       ST056   kidney organic cation transporter   X98333   O15244           3′-phosphoadenosine 5′-phosphosulfate           synthase 1 (PAPS synthase 1; PAPSS1);           PAPS synthetase 1; sulfurylase kinase 1       O43252; O43841;       ST058   (SK1)   Y10387   O75332           multidrug resistance-associated protein 3       O15438; O60265;       ST059   (MRP3); MLP2; ABCC3   Y17151   O60922           senescence marker protein 30 (SMP30);       ST062   regucalcin (RGN; RC)   D31815   Q15493           galactoside 2-I-fucosyltransferase 2; GDP-I-           fucose:beta-D-galactoside 2-alpha-I-           fucosyltransferase 2; fucosyltransferase 2           (FUT2); secretor blood group alpha-2-       ST063   fucosyltransferase; secretor factor 2 (SE2)   D87942   Q10981           ubiquitin cross-reactive protein precursor       ST064   (UCRP); alpha-inducible interferon;   M13755   P05161           interferon-induced 17-kDa protein; G1P2;           ISG15           galactosyltransferase-associated protein           kinase p58 (GTA); cell division cycle 2-like       ST067   1 (CDC2L1;CLK1)   M37712   P21127           spermidine/spermine N1-acetyltransferase           (SSAT); diamine acetyltransferase;       ST068   putrescine acetyltransferase   M55580   P21673           corticoliberin precursor; corticotropin-           releasing factor (CRF); corticotropin       ST072   releasing hormone (CRH)   V00571   P06850           antigen peptide transporter 2 (APT2);           peptide supply factor 2 (PSF2); peptide           transporter involved in antigen processing 2           (TAP2); ATP-binding cassette subfamily B           (MBR/TAP) member 3 (ABCC3); HLA class           II histocompatibility antigen DO beta chain   X66401; L09191;       ST073   precursor   L10287   Q03519                  
 
     [0070] It is evident from the above results and discussion that the subject invention provides a rapid, high throughput means to simply and quickly obtain a broad-scale screening of human stress gene expression in a variety of different samples. Only simple hybridization protocols need be employed with the subject arrays, and signals can be detected using any convenient and readily available detection device. Despite their simplicity, assays conducted with the subject arrays yield a large amount of information regarding the expression of numerous different and important human stress genes associated with cellular responses to stress in a particular sample at substantially the same time. As such, the subject human stress arrays find use in a variety of different applications, including expression profiling of key human stress genes, assays designed to determine the affect of an agent on the expression of human stress genes, and the like.  
     [0071] All publications and patent applications cited in this specification are herein incorporated by reference as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference. The citation of any publication is for its disclosure prior to the filing date and should not be construed as an admission that the present invention is not entitled to antedate such publication by virtue of prior invention.  
     [0072] Although the foregoing invention has been described in some detail by way of illustration and example for purposes of clarity of understanding, it is readily apparent to those of ordinary skill in the art in light of the teachings of this invention that certain changes and modifications may be made thereto without departing from the spirit or scope of the appended claims.