Patent Publication Number: US-8978909-B2

Title: Closure device for a container, and seal member for the device

Description:
TECHNICAL FIELD 
     The present invention relates to a closure device for sealing the opening of a container such as a vial, and to a seal member for the device. 
     BACKGROUND ART 
     A cylindrical vial having a closed bottom is used to contain medicines, various test reagents, or the like. The vial has an opening which opens at the top and through which the content is put in and taken out. Around the opening a rim is formed. The opening is conventionally sealed with a closure device that comprises, for example, an aluminum protector and a seal member. The protector has a wear part on the upper surface, and to the wear part a synthetic resin cap is affixed. The seal member fits into the inner surface of the protector and seals the opening. 
     A medicament contained in the vial is lyophilized as follows. The seal member is attached to the vial in a state in which a flange of the seal member is not in contact with the opening (hereafter referred to as an “incompletely sealing state”), and the vial is placed in a lyophilization apparatus. In the incompletely sealing state, the seal member does not seal the opening, and the inside of the vial containing the medicament communicates with the outside via the opening. By lyophilization in this state, liquid components in the medicament are frozen and then sublimated to be removed from the vial. After the completion of the lyophilization, the seal member is pushed down so as to seal the opening (hereinafter this state is referred to as a “sealing state”). Next, the sealed vial is taken out from the lyophilization apparatus, and the skirt of the protector is wound on the seal member with the use of a winding apparatus. 
     The vial having the aluminum protector is made of, as constituents, four kinds of materials, which are glass, aluminum, synthetic resin, and rubber. These materials are difficult to separate during disposal. In addition, although the vial taken out from a lyophilization apparatus is sealed with the seal member, whose leg has been inserted into the opening, the sealing performance is imperfect. In order to prevent the vial from being biologically contaminated with, for example, bacteria from the outside and to ensure liquid tightness and airtightness, it is necessary to completely seal the opening by winding a protector on the seal member with the use of a winding apparatus as soon as possible after the vial is taken out from the lyophilization apparatus. 
     As a conventional art for solving the above problems, there has been proposed a closure device for a container, comprising a synthetic resin cap provided with a cylinder part and with a top wall, and a seal member that is to be attached to the cap (see, for example, JP-07-165252-A). 
     In this conventional art, the top wall has a window for needle entry, and the cylinder part hangs down from the outer circumference of the top wall. On the inner surface of the cylinder part, a locking means is disposed. The seal member fits into the inside of the cap. The seal member comprises a disk-shaped flange and a cylindrical leg hanging down from the under surface of the flange. 
     The vial is placed in a lyophilization apparatus with its opening provided with the closure device in the incompletely sealing state. After the completion of the lyophilization, the vial is pressed down so that the closure device is pushed down to the sealing state. In this sealing state, the flange is firmly pressed against the periphery of the vial opening by the top wall of the cap. The locking means locks at the under surface of the rim of the vial, thereby holding the cap in a state in which the seal member is firmly pressed against the upper surface of the rim by the top wall. 
     Transition from the incompletely sealing state to the sealing state is achieved as follows: for example, in the lyophilization apparatus, the gaps between the shelves are narrowed, and the upper shelf presses down the vial so as to push down the closure device. When the pressing force is excessively high, the vial may be damaged. Accordingly, the pressing force is set at, for example, 60 N or less. However, size variations occur in, for example, the overall height of the vial, the thickness of the flange, the horizontal level of the shelves of the lyophilization apparatus, the gaps between the multiple shelves, or the like. The size tolerance of, for example, the thickness of the flange is set at ±0.3 mm. 
     Especially when the vial is made of glass, the size tolerance of the overall height of the vial is set at as large as ±0.5 mm. Consequently, it is difficult to securely cap a large number of (for example, 6000) vials at a time without failures by pushing down their closure devices to the sealing state by means of the shelves that move a certain distance. The top wall of the cap may fail to firmly press down the seal member, which may result in sealing failures or decrease in airtightness. 
     As a conventional seal member, there exists a seal member whose upper surface has a projection that is provided between the central part for injection needle insertion and the circumference of the flange. An object of providing this projection is to offer the following advantages, which are attributed to decrease in contact area between the seal member and other things:
     (1) advantage of preventing the seal members from adhering to each other in a production step of the seal member, a filling step of a medicine, or the like;   (2) advantage of preventing the seal member from adhering to the wall of a facility device in a washing step, a sterilization step, a drying step, or the like;   (3) advantage of improving the operability of a parts feeder for the seal member;   (4) advantage of preventing the top of the seal member from adhering by suction to the under surface of the shelf that pushes down the seal member to the sealing state in a lyophilization apparatus, and consequently preventing the vial from being lifted and then tipped over or damaged; and the like.   

     However, even when the seal member having the projection is used to securely cap the vial, the flange may not be sufficiently pushed down by the cap, which may result in sealing failure. In addition, if the size of the projection and/or the thickness of the flange is larger, the pressing force required for capping is excessively high and thus it is difficult to securely cap all the vials with the seal members. 
     The content of the vial is taken out according to the following process. First, from the window for needle entry located in the center of the top wall, an injection needle is inserted into the vial through the center part of the upper surface of the seal member. Next, a dissolving solution or the like is injected into the vial through the needle, and the dissolved content is pumped out with the needle. Unless the flange is firmly pressed against the upper surface of the rim by the cap, the insertion force causes the center part of the seal member to be deformed toward the inside of the vial and, as a result, the insertion may fail. This tendency is greater especially when a larger injection needle, for example, a double-ended needle, a plastic infusion needle (diameter: about 4 mm), or the like is used. Moreover, when an injection needle is obliquely inserted into the vial through the seal member, whose leg hangs down into the opening of the vial, the tip of the injection needle may accidentally stick into the leg. Upon this oblique insertion, unless the flange is firmly pressed down by the cap as described above, further insertion of the needle may draw the flange into the vial along with the leg. 
     SUMMARY OF INVENTION 
     Technical Problem 
     An object of the present invention is to provide a simple closure device for a container, which ensures sealing of the opening of the container with a seal member despite size variations in the overall height of the container, the thickness of a flange of the seal member, or the like. Another object of the present invention is to provide a simple closure device for a container, which ensures insertion of an injection needle or the like into the container through a seal member when the insertion is needed. 
     Solution To Problem 
     In order to solve the above problems, the present invention provides a closure device having the following structure, for example, as shown in  FIGS. 1 to 17B , which show embodiments of the invention. 
     The closure device seals an opening  6  that opens at the top of a container  2  and has a rim  7  on its periphery. The closure device comprises a seal member  8  that is to cover the opening  6 , and a synthetic resin cap  9  that is to press and thereby hold the seal member  8  on the upper surface of the rim  7 . The cap  9  comprises a top wall  15 , a cylinder part  16 , and a locking part  18 . The top wall  15  is to be disposed above a flange  10  of the seal member  8 , and the cylinder part  16  hangs down from the outer circumference of the top wall  15 . The locking part  18  is disposed on the inner surface of the cylinder part  16 . After the cap  9  is pushed down, the locking part  18  locks at the under surface of the rim  7 . The seal member  8  comprises the flange  10  that is to be mounted on the upper surface of the rim  7 . The upper surface of the flange  10  has a compressible projection  29  that projects upward. The compressible projection  29  is annularly arranged in contact with and along the outer circumference of the flange  10  in a planar view. The compressible projection is not limited to a particular size or shape, and may be formed into, for example, a continuous annular ring, a discontinuous annular ring, or the like. 
     The present invention also comprises a seal member having the following structure. 
     The seal member is used for the closure device  1 . The seal member comprises a disk-shaped flange  10  and a leg  11  that hangs down from the under surface of the flange  10 . The seal member also comprises a compressible projection  29  that projects upward from the upper surface of the flange  10 . The compressible projection  29  is annularly arranged in contact with and along the outer circumference of the flange  10  in a planar view. 
     The present invention exerts the following functions and effects. 
     Pushing down the closure device causes the top wall to push down the seal member, and then the leg of the seal member is fully inserted into the container. In this sealing state, the flange is pressed against the upper surface around the opening of a container by the top wall. When the closure device in the incompletely sealing state is pushed down, first the top wall presses down the compressible projection, and then presses down part of the flange just under the compressible projection. After the compressible projection is flattened, the top wall presses down the other part of the flange. That is, via the compressible projection that is pressed and thereby compressed, the flange just under the compressible projection is pressed against the upper surface of the rim around the opening of the container. Since the compressible projection is annularly arranged along the outer circumference of the flange, the downward pressing force through the compressible projection presses part of the flange just under the compressible projection against the upper surface of the rim and, as a result, the opening is sealed. 
     Only the compressible projection along the circumference of the flange is provided on the upper surface of the flange, yet this simple structure is sufficient to ensure sealing of the opening. Since the compressible projection is provided only in part of the upper surface of the flange, the force necessary for pressing down the compressible projection is smaller than the force necessary for pressing down the entire flange. Therefore, a small pressing force, for example, 50 N or less, preferably about 30 N or less per vial is sufficient to ensure capping of the opening. Moreover, the compression of the compressible projection absorbs each size variation occurring within the tolerance, thereby decreasing sealing failures and improving the airtightness. 
     Once the closure device is attached in the sealing state to a container, such as a vial, containing a lyophilized preparation, a powder preparation, a liquid preparation, or the like, the opening of the container is securely sealed by the seal member; thus the inside of the container is completely shut off from the outside and is free from biological contamination, and the liquid tightness and airtightness of the container are maintained. 
     The compressible projection is in contact with the outer circumference of the flange in a planar view and thus the flange&#39;s upper surface surrounded by the outer circumference of the compressible projection is most extensive. When the vial is capped by means of the shelf of a lyophilization apparatus or the like, the pressing force through the top wall received by the compressible projection is evenly distributed to the extensive surface. This structure enables the top wall to uniformly press down the flange, and consequently the upper surface of the seal member is stably kept horizontal. Thus the seal member is set onto the opening of the vial in a proper state. 
     The height of the lateral surface of the flange is increased in the vertical direction by the height of the compressible projection formed on the outer circumference of the flange. When the seal member is attached to the opening of a container in the incompletely sealing state, the flange is not in contact with the top of the container. To the seal member in this state, the cap, whose cylinder part is guided by the lateral surface having the increased height, is attached. Consequently, the cap is attached to the seal member in a proper state in which the central axis of the cylinder part is vertical. 
     The present invention also comprises the following closure device for a container. 
     As shown in, for example,  FIGS. 1 to 17B , the closure device seals an opening  6  that opens at the top of a container  2  and has a rim  7  on its periphery. The closure device comprises a seal member  8  that is to cover the opening  6  and has rubber elasticity, and a synthetic resin cap  9  that is to press and thereby hold the seal member  8  on the upper surface of the rim  7 . The seal member  8  comprises a flange  10  to be mounted on the upper surface of the rim  7 . The cap  9  comprises a top wall  15 , a cylinder part  16 , and a locking part  18 . The top wall  15  is to be disposed above the flange  10 . The cylinder part  16  hangs down from the outer circumference of the top wall  15 . The locking part  18  is disposed on the inner surface of the cylinder part  16 . After the cap  9  is pushed down, the locking part  18  locks at the under surface of the rim  7 . A receiving projection  27  projects downward from an annular part on the under surface of the top wall  15 , the annular part having an inner diameter that is larger than that of the opening  6  and an outer diameter that is smaller than that of the flange  10 . 
     The present invention exerts the following functions and effects. 
     In the sealing state, the flange is pressed against the upper surface around the opening by the top wall, and the receiving projection bites into the upper surface of the flange. Only the receiving projection is provided on the under surface of the cap, yet this simple structure is sufficient to prevent the flange from moving radially inward and to firmly hold the flange between the top wall of the cap and the upper surface of the container. 
     The above structure also prevents the seal member from being deformed toward the inside of the container by the insertion force of an injection needle or the like that is inserted through the center of the seal member in order to take out the content of the container. Even when the tip of the injection needle accidentally sticks into the leg of the seal member, the flange is prevented from being drawn into the container along with the leg. Thus the structure ensures insertion of the injection needle or the like into the container through the seal member. 
     The present invention also comprises the following closure device for a container. 
     As shown in, for example,  FIGS. 6 to 8  or  FIGS. 14A to 17B , the compressible projection  29  is formed into a discontinuous annular ring that is arranged along the outer circumference of the flange  10 . In this embodiment, the space surrounded by the compressible projection communicates with the outside via discontinuous parts. Upon the attachment of the seal member to a container in the incompletely sealing state, or during handling before the attachment, this structure prevents the top of the seal member surrounded by the compressible projection from adhering by suction to attaching means, a handling device, various kinds of processing apparatuses, or the like, as if the seal member were a sucking disk. 
     The present invention also comprises the following closure device for a container. 
     As shown in, for example,  FIGS. 14A and 14B , a plurality of the compressible projections  29  are arranged along the outer circumference of the flange  10 , and each of the compressible projections extends radially inward from the outer circumference of the flange  10 . In this embodiment, when the compressible projections are pressed by the top wall, the flange  10  under the compressible projections  29  is extensively pressed against the rim around the opening. Consequently, the opening is more securely sealed by the seal member. 
     The present invention also comprises the following closure device for a container. 
     The closure device comprises the compressible projection  29  that projects upward from the upper surface of the flange  10 , and the receiving projection  27  that projects downward from the under surface of the top wall  15 , wherein at least part of the compressible projection  29  is positioned radially outward relative to the receiving projection  27 . In this embodiment, the receiving projection receives the compressible projection and prevents the flange from moving radially inward. Consequently, even when atmospheric pressure acts on the center of the seal member, this structure prevents the edge of the flange from moving or becoming thinner, decreases sealing failures, and improves the airtightness. In addition, the flange is firmly held between the top wall of the cap and the upper surface of the container, and thus an injection needle or the like is reliably inserted into the container through the seal member when the insertion is needed. 
     The present invention also comprises the following closure device for a container. 
     As shown in, for example,  FIGS. 1 ,  2 ,  4 , and  5 , the receiving projection  27  is an annular ring that surrounds the opening  6  in a planar view. This embodiment ensures that the receiving projection receives the compressible projection throughout the whole circumference of the opening. The annular ring that surrounds the opening may be discontinuous in the circumference direction. However, the receiving projection is more preferably a continuous annular ring that is arranged along the circumference because the continuous annular ring can more effectively prevent the flange from moving radially inward. The present invention also comprises the following closure device for a container. 
     As shown in, for example,  FIGS. 7 and 8 , the height h of the compressible projection  29  is 10 to 60% of the thickness t of the flange  10  excluding the compressible projection  29 . 
     In this embodiment, the compression of the compressible projection effectively absorbs each size variation occurring within the tolerance, and therefore a small pressing force is sufficient to ensure sealing of the opening with the seal member. The height of the compressible projection is more preferably 20 to 50% of the thickness of the flange. 
     The present invention also comprises the following closure device for a container. 
     As shown in, for example,  FIGS. 1 ,  2 ,  4 ,  5 , and  9 , in a vertical section that passes through the center axis of the opening  6 , the lower edge of the receiving projection  27  has an angle of 90 degrees or less. In this embodiment, the receiving projection is intended to reliably bite into the upper surface of the flange. The angle of the lower edge is preferably set at 70 degrees or less. If the sectional shape of the lower edge is excessively sharp, the lower edge may damage the surface of the seal member and/or the strength of the receiving projection may decrease. Accordingly, the angle of the lower edge is more preferably set at 20 to 65 degrees. In addition, the lower edge is preferably chamfered into, for example, a rounded shape having a radius of about 0.05 mm. 
     The present invention also comprises the following closure device for a container. 
     As shown in, for example,  FIG. 9 , in a vertical section that passes through the center axis of the opening  6 , the receiving projection  27  has a sharp angle α of 45 degrees or less between the surface facing radially outward and the vertical line. In this embodiment, the receiving projection reliably receives the flange against the insertion force of an injection needle or the like, thereby preventing the center part of the flange from being deformed toward the inside of a container. The sharp angle more preferably has an angle of about zero degrees, i.e., the surface facing radially outward of the receiving projection  27  more preferably stands vertically. 
     The present invention also comprises the following closure device for a container. 
     As shown in, for example,  FIG. 5 , the height L of the receiving projection  27  is 0.3 to 2.0 mm. In this embodiment, the receiving projection having a height of 0.3 mm or more reliably receives the flange against the insertion force of an injection needle or the like, thereby preventing the center part of the flange from being deformed toward the inside of a container. Moreover, there is no risk that the receiving projection having a height of 2.0 mm or less would damage the surface of the seal member. 
     The present invention also comprises the following closure device for a container. 
     The seal member  8  is made of at least one of a synthetic rubber material and a thermoplastic elastomer. This embodiment enables the production of the seal member having excellent seal performance with stable quality. 
     The content of the container is not limited to a particular thing, and the content may be, for example, a powder preparation, a liquid preparation, or the like. However, the content is preferably a lyophilized preparation because the closure device has an advantage of, in the incompletely sealing state, being easily pushed down to the sealing state in a lyophilization apparatus. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  is a vertical sectional view of the vial to which the closure device is attached in the incompletely sealing state, showing an embodiment of the present invention. 
         FIG. 2  is a sectional view of the closure device in the sealing state in an embodiment of the present invention. 
         FIG. 3  is a partial fragmentary plan view of the cap in an embodiment of the present invention. 
         FIG. 4  is a sectional view of  FIG. 3  taken along the line IV-IV. 
         FIG. 5  is an enlarged sectional view of the principal part of the cap body in an embodiment of the present invention. 
         FIG. 6  is a plan view of the seal member in an embodiment of the present invention. 
         FIG. 7  is a sectional view of  FIG. 6  taken along the line VII-VII. 
         FIG. 8  is a sectional view of  FIG. 6  taken along the line VIII-VIII. 
         FIG. 9  is an enlarged sectional view of the principal part of the cap, showing Modified Example 1 of an embodiment of the present invention. 
         FIG. 10  is a plan view of the locking member, showing Modified Example 2 of an embodiment of the present invention. 
         FIGS. 11A and 11B  show Modified example 3 of an embodiment of the present invention.  FIG. 11A  is a plan view of the seal member, and  FIG. 11B  is a vertical sectional view of the seal member. 
         FIGS. 12A and 12B  show Modified example 4 of an embodiment of the present invention.  FIG. 12A  is a plan view of the seal member, and  FIG. 12B  is a vertical sectional view of the seal member. 
         FIGS. 13A and 13B  show Modified example 5 of an embodiment of the present invention.  FIG. 13A  is a plan view of the seal member, and  FIG. 13B  is a vertical sectional view of the seal member. 
         FIGS. 14A and 14B  show Modified example 6 of an embodiment of the present invention.  FIG. 14A  is a plan view of the seal member, and  FIG. 14B  is a vertical sectional view of the seal member. 
         FIGS. 15A and 15B  show Modified example 7 of an embodiment of the present invention.  FIG. 15A  is a plan view of the seal member, and  FIG. 15B  is a partial fragmentary view of the seal member. 
         FIGS. 16A and 16B  show Modified example 8 of an embodiment of the present invention.  FIG. 16A  is a plan view of the seal member, and  FIG. 16B  is a vertical sectional view of the seal member. 
         FIGS. 17A and 17B  show Modified example 9 of an embodiment of the present invention.  FIG. 17A  is a plan view of the seal member, and  FIG. 17B  is a vertical section of the seal member. 
     
    
    
     DESCRIPTION OF EMBODIMENTS 
     Embodiments of the present invention will be described below in more details with reference to the drawings. 
       FIGS. 1 to 8  show embodiments of the present invention.  FIG. 1  is a vertical sectional view of a vial  2  (a container) to which the closure device  1  is attached in the incompletely sealing state Y. The vial  2  comprises a cylindrical trunk  3  with a bottom, and the trunk  3  has a storage part  4 . The storage part  4  can contain contents such as a medicine. The upper part of the trunk  3  extends to a neck  5 . The top of the neck  5  has an opening  6 . The periphery of the opening  6  is formed into a rim  7  that swells radially outward. 
     The closure device  1  comprises a seal member  8  and a cap  9 . The seal member  8  is to cover the opening  6  and made of a synthetic rubber having rubber elasticity, for example, a butyl rubber. The cap  9  is to cover the seal member  8  and made of a synthetic resin. 
     The seal member  8  comprises a flange  10  and a leg  11 . The flange  10  is shaped like a disk and is to be mounted on the upper surface of the rim  7 . The leg  11  is shaped like a cylinder that hangs down from the radially intermediate part of the under surface of the flange  10 . The leg  11  has a notch  12  extending from the bottom of the leg  11  to the middle part of the seal member in the vertical direction. The top of the notch  12  is to be positioned above the opening  6  in the incompletely sealing state Y as shown in  FIG. 1 . The inside of the storage part  4  communicates with the outside of the vial  2  via the opening  6  and the notch  12 . The outer diameter of the leg  11  is slightly larger than the inner diameter of the opening  6  and thus, when the leg  11  is inserted into the opening  6 , the leg  11  is slightly compressed. 
     The cap  9  comprises a cap body  13  and a lid  14  that is fixed on the top of the cap body  13 . The cap body  13  comprises a top wall  15 , a cylinder part  16 , and an annular locking member  17 . The top wall  15  is to be disposed above the flange  10 . The cylinder part  16  hangs down from the outer circumference of the top wall  15 . The locking member  17  is attached to the inner surface of the cylinder part  16 . On the top of the locking member  17 , a locking part  18  is formed. In the center of the top wall  15 , a window for needle entry  19  opens. From the center of the under surface of the lid  14 , a cylindrical sealer  20  hangs down, passing through the window for needle entry  19 . 
     After the content of the vial  2  is lyophilized, the vial is pressed down from the above so that the closure device  1  is pushed down to the sealing state X as shown in  FIG. 2 . In the sealing state X, the flange  10  is firmly pressed against the upper surface around the opening  6  by the top wall  15 , and thereby the opening  6  is sealed. In this state, the locking part  18  locks at the under surface of the rim  7  of the vial  2 , thereby holding the cap  9  in the sealing state X. The bottom of the sealer  20  bites into the upper surface of the seal member  8 , and consequently the space above the center of the upper surface of the seal member  8  is airtightly shut off from the outside. 
     As shown in  FIGS. 3 and 4 , on the upper surface of the cap body  13  formed are two depressions  21  as gates for injection molding, and an annular groove  22  surrounding the window for needle entry  19 . On the under surface of the lid  14 , four joining projections  23  stick out. The bottoms of the joining projections  23  are welded onto the inner surface of the groove  22 , so that the lid  14  is fixed onto the upper surface of the cap body  13 . 
     As shown in  FIG. 4 , a fitting ridge  24  that is annularly formed on the inner surface of the cylinder part  16  fits into the locking member  17 . On the locking member  17 , at predetermined intervals a plurality of locking parts  18  stick out obliquely upward and radially inward. Each of the locking parts  18  has a hinge  25  at the base. The upper part can be inclined radially outward. On the inner surface of the above locking member  17 , ventilation openings  26  are provided between each locking part  18  in a planar view. In the incompletely sealing state Y as shown in  FIG. 1 , the storage part  4  communicates with the outside via the opening  6 , the notch  12 , and then the ventilation openings  26 . 
     As shown in  FIGS. 2 and 4 , the under surface of the top wall  15  of the cap body  13  has a receiving projection  27 . The receiving projection  27  projects downward from the top wall&#39;s annular part whose inner diameter is larger than that of the opening  6  and whose outer diameter is smaller than that of the flange  10 . The receiving projection  27  is a continuous annular ring that surrounds the opening  6  in a planar view.  FIG. 5  shows a vertical section of the receiving projection  27 . The vertical section passes through the central axis  28  of the opening  6 . The sectional shape of the lower edge of the receiving projection  27  is formed to have an angle of 90 degrees or less, for example, 45 degrees. In this vertical section, the surface facing radially outward of the receiving projection  27  stands vertically along the central axis  28 . The height L of the receiving projection  27  is set at, for example, 0.5 mm. 
     The seal member  8  has a compressible projection  29  on the upper surface of the flange  10 . As shown in  FIGS. 6 to 8 , in a planar view, the compressible projection  29  is annularly arranged in contact with and along the outer circumference of the flange  10 . Consequently, the height of the lateral surface of the flange  10  is increased in the vertical direction by the height of the compressible projection  29 , as shown in, for example,  FIGS. 7 and 8 . The cap  9  and the seal member  8  are to be attached to the vial  2  in the incompletely sealing state Y as shown in  FIG. 1  as follows: first the seal member  8  is attached to the opening  6 , and then the cap  9 , whose cylinder part  16  is guided by the lateral surface having the increased height, is attached to the seal member  8  in a proper state in which the central axis of the cylinder part  16  is vertical. 
     The compressible projection  29  has four discontinuous parts  30  in the circumference direction, and the space surrounded by the compressible projection  29  communicates with the outside via these discontinuous parts  30 . This structure can effectively prevent the seal member  8  from adhering by suction to attaching means, a handling device, various kinds of processing apparatuses, or the like, as if the seal member were a sucking disk, upon the attachment of the seal member  8  to the vial  2  in the incompletely sealing state Y, or during processing before the attachment, such as handling, washing, and sterilization. In addition, a depression for needle insertion  31  is provided on the center of the upper surface of the flange  10 . In the present invention, instead of the four discontinuous parts  30  provided on the compressible projection  29  in the circumference direction, three or less, or five or more discontinuous parts may be provided in the circumference direction. 
     As shown in  FIG. 1 , the receiving projection  27  is positioned radially inward relative to the compressible projection  29 . The receiving projection  27  is intended to receive the compressible projection  29  in order to prevent the seal member  8  from moving radially inward or being deformed. The height h of the compressible projection  29  is set at, for example, 0.8 mm. When the thickness t of the flange  10  excluding the compressible projection  29  is, for example, 3.5 mm, this height is set at about 23%. 
     The closure device  1  is to be attached to the vial  2  in the incompletely sealing state Y as shown in  FIG. 1 . The vial  2  is placed in a lyophilization apparatus (not shown), and the content of the vial  2  is lyophilized under reduced pressure. Next, the vial  2  is pressed down from the above by a shelf of the lyophilization apparatus so that the closure device  1  on the vial  2  is pushed down to the sealing state X as shown in  FIG. 2 . On this pressing, first the top wall  15  of the cap body  13  presses down the compressible projection  29  of the seal member  8 , and then presses down part of the flange  10  just under the compressible projection  29 . After the compressible projection  29  is flattened, the top wall  15  presses down the other part of the flange  10 . After the completion of these pressing, the receiving projection  27  bites into the upper surface of the flange  10  as shown in  FIG. 2 , and the flange  10  is consequently firmly held between the top wall  15  of the cap  9  and the upper surface of the vial  2  and prevented from moving radially inward. 
     The compressible projection  29  is merely part of the entire flange  10 , and consequently the compressible projection  29  is easily pressed down with a small pressing force. Via the compressible projection  29 , the flange  10  under the compressible projection  29  is pressed against the upper surface around the opening  6  of the vial  2 . Since the compressible projection  29  is annularly arranged along the outer circumference of the flange  10 , the downward pressing force through the compressible projection  29  presses part of the flange  10  just under the compressible projection against the upper surface of the vial  2  and, as a result, the opening  6  of the vial  2  is sealed from the outside. The height of the compressible projection  29  is set so as to sufficiently absorb each size variation occurring within the tolerance. Owing to the height, even a small pressing force, for example about 30 N per vial, is sufficient to ensure capping of the opening  6  of the vial  2 . 
     The compressible projection  29  is in contact with the outer circumference of the flange  10  in a planar view and thus the flange  10 &#39;s upper surface surrounded by the outer circumference of the compressible projection  29  is most extensive; thus pressing force through the cap  9  is evenly distributed and the flange  10  is pressed down uniformly. Moreover, when pressed down by the top wall  15  of the cap  9 , the upper surface of the seal member  8  is stably kept in horizontal and the seal member  8  is set onto the opening  6  in a proper state. 
     The content of the vial  2  that is sealed with the closure device  1  is taken out as needed according to the following process. 
     First, the lid  14  of the cap  9  is removed from the cap body  13  by breaking the joining projections  23 , and the depression for needle insertion  31  on the seal member  8  is exposed to the outside through the window for needle entry  19 . Next, an injection needle is inserted into the vial through the depression for needle insertion  31  in order to inject a dissolving solution or the like for reconstituting the content of the storage part  4  of the vial  2 . The content is then pumped out with the injection needle. 
     When the injection needle is inserted into the vial  2  through the depression for needle insertion  31 , the structure having the receiving projection  27  that bites into the upper surface of the flange  10  and the receiving projection  27  that receives the compressible projection  29  prevents the flange  10  from moving radially inward. This structure also prevents the seal member  8  from being deformed toward the inside of the vial  2 . Further, even when the tip of the injection needle accidentally sticks into the leg, the structure prevents the flange  10  from being drawn into the vial  2  along with the leg. Thus the structure ensures smooth insertion of the injection needle into the vial  2  through the seal member  8 . 
     In the above embodiment, the receiving projection  27  has a sectional shape whose surface facing radially outward stands vertically along the central axis  28  of the opening  6 . However, the sectional shape of the receiving projection of the present invention is not limited to a particular shape. 
     For example, as shown in Modified Example 1 in  FIG. 9 , in the vertical section passing through the central axis of the opening, the angle of the lower edge of the receiving projection  27  is set at about 60 degrees. The sharp angle (α) between the surface facing radially outward and the vertical line is set at 45 degrees or less, for example, 30 degrees. 
       FIG. 10  shows Modified Example 2 of an embodiment of the present invention. On the inner surface of the locking member  17 , a stabilizer  32  is provided in each of the ventilation openings  26  that are longitudinally provided between each locking part  18 . The diameter of a virtual circle that passes through the inner edges of each stabilizer  32  is set at about the same as the outer diameter of the rim  7  of the vial  2 , or slightly smaller than the outer diameter of the rim  7 ; thus the cap having said locking member  17  is to be attached to the vial in a proper incompletely sealing state Y, in which the central axis of the cylinder part  16  corresponds with the central axis  28  of the opening  6  of the vial  2 . 
     The compressible projection  29  on the seal member  8  can be formed into various shapes as needed, for example, as shown in Modified Examples in  FIGS. 11A to 17B . 
     In Modified Example 3 in  FIGS. 11A and 11B , the compressible projection  29  is formed into a continuous annular ring not having any gaps. This compressible projection  29  has a plurality of lower parts  33 , whose heights are lower than that of the annular ring. The lower parts  33  allow the space surrounded by the compressible projection  29  to communicate with the outside, and thus prevent the seal member  8  from adhering by suction to other things. 
     In Modified Example 4 in  FIGS. 12A and 12B , the compressible projection  29  is formed into the same continuous annular ring not having any gaps as in Modified Example 3 except that, instead of the lower parts  33 , projections for adhesion prevention  34  are formed on the upper surface of the compressible projection  29  in order to prevent the seal member  8  from adhering to other things. The space around the projections for adhesion prevention  34  allows the space surrounded by the compressible projection  29  to communicate with the outside. 
     In Modified Example 5 in  FIGS. 13A and 13B , the compressible projection  29  is formed into dots that are annularly disposed in a planar view. The compressible projections  29  are connected to each other by an annular portion  35 , which is positioned under the compressible projections  29 . 
     In Modified Example 6 in  FIGS. 14A and 14B , a plurality of the compressible projections  29  are formed along the outer circumference of the flange  10 . The compressible projections  29  are each formed into an oval body that extends radially inward in a planar view. When the compressible projections  29  are pressed down by the top wall of the cap, the flange  10  under the compressible projections  29  is extensively pressed against the upper surface of the vial  2 . 
     In the above embodiments and Modified Examples, the seal member  8  has the depression for needle insertion  31  in the center of the upper surface of the flange  10 . In the present invention, however, the depression for needle insertion  31  may be omitted, and a needle insertion site  36  having the same thickness as the thickness t of the flange  10  may be provided in the center of the upper surface of the flange  10 . Examples of the needle insertion site  36  are shown in Modified Example 7 in  FIGS. 15A and 15B  and Modified Example 8 in  FIGS. 16A and 16B . 
     In Modified Example 7 in  FIGS. 15A and 15B , as described in the above embodiments, the seal member  8  has four compressible projections  29  that is arranged along the outer circumference of the upper surface of the flange  10 . Unlike the above embodiments, the center of the upper surface of the flange  10  has no depression for needle insertion but has the needle insertion site  36  that has the same thickness as the thickness t of the flange  10  and is surrounded by an annular ridge  37 . The annular ridge  37  is formed into an annular ring not having any gaps. The projection height of the annular ridge  37  is lower than that of the compressible projection  29 , and therefore there is no risk that the annular ridge  37  would be in contact with or adhere by suction to other things during processing such as handling, washing, and sterilization. 
     The other structures and their functions are the same as those of the above embodiments, and the explanations for them are omitted accordingly. 
     In Modified Example 8 shown in  FIGS. 16A and 16B , three compressible projections  29  are arranged along the outer circumference of the upper surface of the flange  10 . The other structures and their functions are the same as those of Modified Example 7, and the explanations for them are omitted accordingly. 
     The above embodiments and Modified Examples explain only the closure device used for a vial that contains a lyophilized preparation and the seal member for such a closure device. However, the closure device of the present invention can also be attached to a container for containing a powder preparation, a liquid preparation, or the like. In this case, attachment in the incompletely sealing state is not required: after desired contents are put in the container, the closure device only has to be attached to the opening in the sealing state. For this purpose, the leg  11  of the seal member  8  is formed into a shorter cylinder as shown in, for example, Modified Example 9 in  FIGS. 17A and 17B . The notch  12  provided in the above embodiments and Modified Examples is omitted from the leg  11  in Modified Example 9. The other structures and their functions are the same as those of Modified Example 8, and the explanations for them are omitted accordingly. 
     The closure devices explained in the above embodiments and Modified Examples are only examples for demonstrating the technical idea of the present invention. The shape, size, material, and the like of each part are not limited to the embodiments or Modified Examples, and can be variously modified within the scope of the claims of the present invention. 
     For example, the above embodiments are preferable in that the combination of the compressible projection on the seal member and the receiving projection on the top wall of the cap enables the seal member to seal the opening and to suitably keep the sealing state. In the present invention, however, when the receiving projection is provided, the compressible projection is not limited to the above embodiments or Modified Examples. The compressible projection may be any other projection that also has another use, for example, a projection that prevents adhesion to other things during handling. The compressible projection may be positioned radially inward relative to the outer circumference of the flange as long as the compressible projection is positioned radially outward relative to the receiving projection. In the present invention, either of the compressible projection and the receiving projection may be omitted. 
     In the above embodiments, the locking part is formed on the locking member, which is a different member from the cylinder part. In the present invention, however, the locking part may be integrated into the cylinder part. Further, the cylinder part may have a slit or a vent that connects the storage part of the vial to the outside. 
     In the above embodiments, the window for needle entry that is provided in the top wall of the cap body is covered with the lid, and the lid is removed by breaking the joining projection. This structure enables an opened vial to be easily distinguished from an unopened vial. In the present invention, however, the lid may be omitted and the window for needle entry may be covered with, for example, a closure film that is unable to be re-sealed, or the like. 
     In the above embodiments, a synthetic rubber material such as a butyl rubber is used for the seal member. In the present invention, however, the seal member may be made of a material whose main raw material is another synthetic rubber, a thermoplastic elastomer, or the like. In the above embodiments, explanations are made for cases where the content is lyophilized. However, other kinds of contents such as a powder preparation and a liquid preparation may be contained in the vial for the present invention without being lyophilized. In addition, the inside of the vial may be at positive pressure, besides in vacuo or at reduced pressure, and also may be filled up with an inert gas such as nitrogen gas. Needless to say, the sectional shape, size, or the like of the receiving projection and the compressible projection is not limited to the above embodiments.