Patent Publication Number: US-2021170780-A1

Title: System and method for generating an integrated label for container housing multi-script pouches

Description:
FIELD OF THE INVENTION 
     The invention relates to a system and method for integrating and labeling a plurality of tablet orders. More particularly, the invention relates to generating an integrated order from multiple tablet orders and labeling a package containing an integrated order with information about the tablets contained in the package. 
     CROSS-REFERENCE TO RELATED PATENT APPLICATIONS 
     The present patent application claims the priority of provisional patent application No. 61/248,471, filed Oct. 4, 2009. The present patent application is also a continuation-in-part of patent application Ser. No. ______ 
     BACKGROUND 
     There are a variety of problems encountered by individuals taking multiple prescription medications simultaneously. A principal concern is determining whether all medications have been taken in compliance with the prescribed daily regimen. Many times this concern is compounded by the requirement that portions of the various medications must be taken at different times during the day as well as in different amounts or quantities. For instance, some individuals, e.g., those suffering from certain psychological disorders, may require varying quantities of a particular medication. For example, a patient receiving lithium may require a low dosage of the medication when administration begins (e.g., 200 mg). However, as the patient&#39;s treatment continues, stronger doses (e.g., 300 mg) may be prescribed as the patient&#39;s levels are titrated upward from the starting level. Thus, a patient receiving lithium may be prescribed a single 200 mg pill for the first three days of treatment, whereafter stronger pills, or additional doses of weaker pills, are prescribed. 
     The fear of taking improper dosages of prescribed medications can be particularly acute in the elderly, many of whom have some degree of mental dementia and can easily be confused as to whether they have taken all of their mediations at the correct time. Some patients with limited mental abilities have difficulty simply sorting their various medications in preparation for taking them and, thereafter, taking them in a timely manner (i.e., in compliance with their dosing cycle). Providing medications to disabled and/or incapacitated individuals can also be a problem for caregivers, particularly those in hospitals and assisted living facilities where one caregiver may oversee the medication of many patients. 
     Thus, there is a need for an automated system for ordering and integrating multiple prescription medications, whereby patients may receive consolidated groups of medications for administration (e.g., usually, consumption) at prescribed dosing intervals and in prescribed, possibly varying, quantities. Such a system would decrease the possibility of human error and provide a simple mechanism for the correct selection, verification, integration, packaging and delivery of multiple prescription medications (also referred to as “multi-scripts”). 
     There is also a need for a similar system for ordering and integrating multiple non-prescription medications. Many individuals take a large variety of vitamins, herbal supplements, herbs, oils, nutraceuticals, and other similar non-prescription medications. As with prescription medications, these drugs may also require variable dosing cycles/intervals, and the advantages that accrue from an integrated order packaged with all of the medications for a particular date and dosing interval are associated with non-prescription medications in substantially the same proportion that they are associated with prescription medications. 
     There is currently a lack of packaging solutions (either front-end or back-end) that allow a patient, doctor or caregiver to generate an integrated label for multiple medications. Thus, there is a need for a system capable of generating an integrated label, preferably a system capable of operating with any front-end pharmacy solution and any back-end automated filling robot. 
     The following description provides a convenient and efficient way for patients, pharmacists, and physicians to place orders for multiple tablets. The description also provides a system and method for integration of the multiple tablet orders, whereby patients may receive consolidated groups of tablets for administration at prescribed dosing intervals and prescribed quantities. 
     SUMMARY 
     A system for integrating and labeling a plurality of tablet orders is described. The system comprises a graphical user interface configured to receive a first input for a first plurality of tablets associated with a particular patient. The graphical user interface also receives a second input for a second plurality of tablets associated with the particular patient. The system further comprises a software module configured to compile the first input and the second input into an integrated order. The system also comprises an integrated label coupled to a package containing a first dose from the first plurality of tablets and a second dose from the second plurality of tablets. The integrated label indicates information about the first dose and the second dose. 
     In another embodiment, the system for integrating and verifying a plurality of tablet orders comprises a secondary container configured to contain a plurality of packages. The secondary container comprises a secondary label. 
     A method for integrating and labeling a plurality of tablet orders is also described. The method comprises receiving with a graphical user interface a first input for a first plurality of tablets associated with a particular patient. A second input for a second plurality of tablets associated with a particular patient is also received with the graphical user interface. The method further comprises compiling with a software module the first input and the second input into an integrated order. The method further comprises generating with the software module an integrated label to couple to a package containing a first dose from the first plurality of tablets and a second dose from the second plurality of tablets. The integrated label indicates information about the first dose and the second dose. 
    
    
     
       DRAWINGS 
       The present invention will be more fully understood by reference to the following drawings which are for illustrative, not limiting, purposes. 
         FIG. 1  shows an illustrative flowchart showing an overview of the process used to go from prescription entry to order shipment. 
         FIG. 2  shows a plan view of an illustrative EPPA GUI main screen. 
         FIG. 3  shows a plan view of an illustrative EPPA GUI for patient information entry. 
         FIG. 4  shows an illustrative flow chart demonstrating the method of entering a new patient into the system. 
         FIG. 5  shows an illustrative GUI for prescription order entry. 
         FIG. 6  shows an illustrative flow chart depicting the process A 00  for entering a new prescription order into the system. 
         FIG. 7  shows a flow chart of an illustrative process  700  for entering a refill Prescription. 
         FIG. 8  shows an illustrative process EPPA GUI for entering a new prescription, including the scanned handwritten prescription. 
         FIG. 9A  illustrates an embodiment of the prescription input verification process. 
         FIG. 9B  shows a first view of a graphical user interface configured to facilitate patient and order selection. 
         FIG. 9C  shows a first view of a graphical user interface configured to facilitate patient and order selection. 
         FIG. 9D  shows a first view of a graphical user interface configured to facilitate prescription input verification. 
         FIG. 9E  shows a second view of a graphical user interface configured to facilitate prescription input verification. 
         FIG. 10  shows an illustrative patient interface, including package selection options. 
         FIG. 11  shows an illustrative grouping for a 30-day tablet regimen for one illustrative type of compliance packaging. 
         FIG. 12  shows a label area on a pre-assembled blank that is similar to the containers shown in  FIG. 11 . 
         FIGS. 13A-13B  show an isometric view of the 30-day tablet dispensing container, with the top and front expanded, respectively. 
         FIGS. 14A-14B  show a top view and a bottom view of a plurality of illustrative sealed multiple prescription containers. 
         FIG. 15  shows an exploded isometric view of an illustrative multiple prescription container assembly. 
         FIG. 16  shows an isometric view of an illustrative multiple prescription container assembly. 
         FIG. 17  shows a top plan view of a plurality of illustrative multiple prescription container assemblies, coupled to one another. 
         FIGS. 18A and 18B  are perspective views of another embodiment of a medicament container. 
         FIG. 19  is a perspective view of a compliance wheel interacting with one of a plurality of medicament containers. 
         FIG. 20  is a perspective view of an embodiment of an illustrative spiral packaging system with a transparent exterior, shown with a compliance wheel and a plurality of medicament containers. 
         FIG. 21  is a perspective view of an illustrative spiral packaging system. 
         FIG. 22  is a perspective view of a portion of the child proof mechanism of the illustrative spiral packaging system of  FIG. 21 . 
         FIG. 23  is a front elevation view of the portion of the child proof mechanism of the illustrative spiral packaging system of  FIG. 21  showing operation of the child safety component. 
         FIG. 24A  shows a group of seven separable pouches, wherein each pouch comprises a plurality of different tablets. 
         FIG. 24B  shows an exploded view of the illustrative front side of one of the sealed center cut pouches that is included in the strip of pouches. 
         FIG. 24C  shows an exploded view of the illustrative back side of the pouch in  FIG. 24B . 
         FIGS. 25A-25G  show an illustrative label on the folded box. 
         FIG. 26  shows an illustrative GUI including a portion of the Patient Information Booklet before printing. 
         FIG. 27  shows a flowchart of one illustrative embodiment of the inspection process. 
     
    
    
     DESCRIPTION 
     Persons of ordinary skill in the art will realize that the following description is illustrative and not in any way limiting. Other embodiments of the claimed subject matter will readily suggest themselves to such skilled persons having the benefit of this disclosure. It shall be appreciated by those of ordinary skill in the art that the systems and apparatus described hereinafter may vary as to configuration and as to details. Additionally, the methods may vary as to details, order of the actions, or other variations without departing from the illustrative methods disclosed herein. 
     The ordering system described herein may operate with any front-end pharmacy solution and any back-end automated filling robot. The goal is to consolidate prescription or other tablet orders by combining the orders and generating an output. This is done by putting all the orders into a database and then gathering information about each order and then combining this information with a photograph of each tablet that is also stored in the database. The consolidated order information with the associated written information and pictures of the tablets are combined into one booklet that is referred to as a patient information booklet. 
     Tablets as used herein may refer to any form of prescription or non-prescription medication in the form of caplets, pills, capsules, powders, liquids, gels, or suppositories, including vitamins, supplements, herbal formulations, or combinations thereof, intended to be ingested by or administered to a patient to improve the patient&#39;s health or well being. 
     The integrated label includes color pictures of the tablets. Additionally, the integrated label includes dosage periods (morning, noon, afternoon, evening) and information specific to the time frame (start date, no start date, week, month, 90-day period). The labeling may be in large alphanumeric text for improved legibility for the visually impaired. 
     Note, labeling may accommodate blind patient as shown and described in more detail in U.S. Provisional Application No. 61/245,912, filed Sep. 25, 2009, which is hereby incorporated by reference. 
     The integrated labeling is associated with the Patient Information Booklet (PIB). The PIB includes standardized language that corresponds to each medication. The PIB combines information associated with a plurality of medications into a single document. The PIB is included in the mail order package that is sent to the customer. The PIB is associated with the multi-prescription container and the integrated label, and the three are combined before being placed into a shipping container. 
     Referring to  FIG. 1 , there is shown an illustrative flowchart describing the overall process used to go from prescription entry to order shipment. At block  102 , the enrollment form is received from a new patient. Proceeding to block  104 , the enrollment form may be accompanied by the patient&#39;s written prescriptions, or the prescriptions may be faxed or otherwise delivered by the patient&#39;s physician(s). At block  106 , the patient information is entered into the front-end system. In this illustrative embodiment, the front-end system is PharmaServe. Once the patient has been entered into PharmaServe, additional information including billing information and patient packaging preferences may be entered into Edge Prescription Processing Application (EPPA) at block  108 . The method then proceeds to block  110 , where the prescription order is verified. 
     Once the patient and prescription information have been entered into the front-end system and into EPPA, each prescription is now associated with a particular patient&#39;s individual regimen. The prescriptions are grouped and treated as one order within the EPPA system. This function is not available in PharmaServe or in other known front-end systems. The verified order is treated as a whole order from this point on in the process. Any additional prescriptions that the patient may require in the future may be added to the patient&#39;s order when prescriptions are next filled. 
     Moving on to block  112 , the verified prescription order that is associated with a particular patient and corresponds to specific dates for administration is forwarded to production and filled. The illustrative interface, EPPA, communicates with the back-end (filling) system, allowing the prescriptions to be grouped as an order during filling. In one illustrative embodiment, the back-end system is Pac-Med. 
     The filling process uses automated techniques. During the filling process, the tablets that are associated with the prescription order may be loaded into compliance containers that are configured for use with the system and methods described herein, such as those described in U.S. patent application Ser. No. 11/923,321, filed Oct. 24, 2007, which is hereby incorporated by reference. Embodiments of compliance containers that are configured to be used with the system and methods herein are also described in more detail below. 
     The particular type of compliance container that is used during filling is chosen according to patient packaging preferences. 
     Referring now to block  114  of  FIG. 1 , the method proceeds to printing of the integrated label and the patient information booklet. The integrated labeling displays information relating to the patient. In some embodiments, a photograph of the patient may appear on the integrated labeling. Integrated labeling also displays detailed information about the tablets included in the prescription order. In some embodiments, color images of the tablets are included next to their names and descriptions. Further, integrated labeling contains drug precaution information corresponding to the tablets in the order. Integrated labeling may also include patient-specific or prescription order-specific information, such as details about interactions between two tablets in the order or interactions that the drug may have based on information that is specific to the patient, like age or the disease that is being treated. It is important to note that the steps of block  112  and  114  may also occur in reverse order, or simultaneously, without deviating from the system and methods described herein. 
     Also at block  114 , the patient information booklet is printed. The patient information booklet is a consolidated booklet that displays information related to each tablet in the prescription order. The patient information booklet may display all, or a portion of, the information that may be included on the drug information insert that accompanies medications when they are dispensed in pill containers that hold just one type of tablet. The patient information booklet may also include more detailed information of the types described above in reference to integrated labeling, and it may contain other information related to the patient and/or the prescription order that may be useful to the patient or caregiver who uses the compliance packaging and patient information booklet. 
     Moving on to block  116 , the filled order is inspected. The inspection process includes verifying that the tablets to be dispensed are properly associated with the particular patient and prescription order. The inspection process also includes inspection of the filled packages to ensure that the distribution of the tablets within the containers is consistent with the patient&#39;s dosage regimen. Further, the integrated labeling corresponding to a particular time period and specific dates for administration is associated with the strip of pouches or cups that contain the associated tablets. The integrated labeling associated with the order is also inspected and verified to be of legible print quality. Inspected strips are matched with the appropriate secondary container and the corresponding integrated labeling. 
     Moving on to block  118 , the strips are sealed within the appropriate secondary container, and all secondary containers corresponding to a complete order are placed into a shipping container. Moving on to block  120 , the shipping container with the prescription order within is forwarded to shipping for delivery to the patient. 
     Referring to  FIG. 2 , there is shown a plan view of an illustrative EPPA Graphical User Interface (GUI) main page  200 . Starting on the left side of the illustrative GUI  200 , there is shown a series of tabs  202 - 214 . Each tab is associated with a particular set of tasks or type of information that needs to be interacted with. “People” tab  202  is highlighted in this illustrative image. Other illustrative tabs that are associated with steps in processing a patient prescription order include “Verification” tab  204 , “Inspection” tab  206 , “Shipping” tab  210 , and “Production” tab  212 . The illustrative “History” tab  208  allows a user of the GUI to pull up information related to the patient&#39;s history and the history of any previous associated prescription orders. The illustrative “Utility” tab  214  allows a user to manipulate EPPA settings and the like. 
     Since the people tab  202  is highlighted, “People” folder  216  is displayed at the top of the display area  222  to the right of the tabs  202 - 214  discussed above. The people folder  216  is shown in an expanded view, and subfolders physician  218 , patient  220 , guardian  224 , payor  226 , user  228 , or institution  230  may be selected. These subfolders enable a user to obtain additional information about a person or entity of the type listed, or to enter such information. Below display area  222  is a series of buttons that include new patient button  232 , refill button  234 , and new prescription button  236 . Search box  238  also enables a user to enter a search term in order to find or enter information. 
     Referring to  FIG. 3 , there is shown a plan view of an illustrative EPPA GUI for patient information entry. The illustrative patient information entry GUI  300  is included under the highlighted people tab  202 , as shown. The illustrative GUI  300  includes an area to enter or view information about the patient&#39;s address and contact information  302 . Information corresponding to a patient&#39;s name  312 , street  314 , city  316 , state  318 , zip  320 , email  322 , home phone  324 , work phone  326 , cell phone  328 , or fax number  330  may be entered. If an individual other than the patient is the contact person for billing, the check box  310  may be unchecked and billing address and billing contact information  304  may be entered or viewed. 
     Additional patient information  306  may be entered, including the patient&#39;s gender  332 , date of birth  334 , parent/guardian  336 , spouse  338 , Social Security number  340 , insurance provider(s)  342 , insurance group ID  344 , credit card information  346 , cardholder name  348 , card expiration date  350 , password  352 , and language choice  354 . If the shipping address and contact information  308  is different than both the patient information  302  and the billing contact information  304 , then the choice “Different” may be clicked of the options  356 , and the shipping information  308  may be entered. 
     Referring to  FIG. 4 , there is shown an illustrative flow chart depicting the process  400  for entering a new patient into the system. First, at block  402 , the enrollment form is received from the patient. The enrollment form is typically accompanied by the new patient&#39;s written prescriptions, or by an instruction for the patient&#39;s physician(s) to be contacted to obtain the prescription information. Next, at block  404 , the patient&#39;s name is entered into the database. In this illustrative embodiment, the patient name is entered into the illustrative front-end system, PharmaServe. The method then proceeds to decision diamond  406 , where it is determined if the patient is already in the database. If the patient is in the database, the patient is not a new patient and the method proceeds to EPPA (Edge Prescription Processing Application) entry at block  416 . If the patient is not in the database at decision diamond  406 , the method proceeds to block  408 , where the rest of the patient information is entered, possibly including patient information of the types described above for  FIG. 3  EPPA patient entry. The method then proceeds to block  410 , where any patient allergies are entered into the system. Proceeding to block  412 , any patient medical conditions are entered, and moving on to block  414 , the patient&#39;s detailed carrier coverage information is entered. The method then proceeds to block  416 , where EPPA entry begins, and on to decision diamond  418 , where it is determined if the patient is in the EPPA database list. If not, the method returns to block  404 . If so, the method moves on to block  420 , where patient billing information including credit card, driver license number and state is entered into a GUI similar to the one shown in  FIG. 3 . Patient notes that may describe anything related to the patient and/or the disease for which the patient is being treated and/or the prescription(s) that the patient is taking may also be entered. Moving to block  422 , any patient packaging preferences are entered. Finally, the method proceeds to block  424 , and the new prescription entry process begins (shown in more detail in  FIG. 6 ). 
     Referring now to  FIG. 5 , there is shown an illustrative GUI for entering additional prescription information. This information includes data about the insurance the covers the prescription, coverage (Cvg) information  502 , prescriber information  504 , refills authorized (Rfls Auth)  510 , instructions (Inst)  512 , frequency (Freq Ovrd)  514 , the number of days supply  516 , the origin of the tablets to be filled  518 , the date the prescription was written  520 , the date the prescription is being dispensed  522 , the prescription expiration date  524 , the pharmacist who is supervising the fill  526  and the hours of administration (HOA) information  528 . 
     Referring now to  FIG. 6 , there is shown an illustrative flow chart depicting the process  600  for entering a new prescription order into the system. At block  602  of the method  600 , patient selection criteria are entered into PharmaServe. Patient selection criteria may include patient last name, patient phone number, or other identifying information. The method then proceeds to decision diamond  604 , where it is determined if the patient name is in the list of patients. If the name is not in the list of patients, the method proceeds to block  622 , where method  400  (described in  FIG. 4 ) is performed. If the patient name is found in the list of patients, the method proceeds to block  606 , where the patient name is selected from the list. At block  608 , the name of a new prescription associated with the patient is entered. 
     The method then proceeds to block  610 , where additional information relating to the prescription is entered. This information is entered into an illustrative GUI similar to the one presented in  FIG. 5 . This information may include coverage (Cvg) information  502 , prescriber information  504 , refills authorized (Rfls Auth)  510 , instructions (Inst)  512 , frequency  514 , the number of days supply (Days (supply))  516 , the origin of the tablets to be filled  518 , the date the prescription was written  520 , the date the prescription is being dispensed  522 , the prescription expiration date  524 , and the pharmacist who is supervising the fill  526 . 
     Referring back to  FIG. 6 , the method proceeds to block  612 , where the HOA code  528  (shown in  FIG. 5 ) corresponding to the time(s) and frequency that the medication should be taken is entered. The HOA code enables an individual prescription to be integrated into an individualized regimen and associated with the proper medicament container for eventual administration. 
     The method then proceeds to decision diamond  614 . If the patient has additional new prescriptions to be added, the method returns to block  606 . If all new prescriptions have been added to the system, the method proceeds to  616 , where the illustrative “Bill Now” command is entered, which ends the data entry process. The method then proceeds to block  618 , where the handwritten prescriptions corresponding to each prescription to be dispensed are scanned into the system. Finally, the method proceeds to block  620 , where the order is complete. 
     Referring now to  FIG. 7 , an illustrative process  700  for entering a refill prescription is shown. At decision diamond  702 , the method selects whether the prescription is known. If not, the method proceeds to block  716 , where at least one patient selection criterion is entered, and on to block  718 , where the patient name is selected from a list. The method then proceeds to block  720 , where the prescription to be refilled is selected from a list associated with the patient. 
     Alternatively, if the prescription number is known at decision diamond  702 , the method proceeds to block  704 , where the prescription number is entered. In either case, the method proceeds from either block  704  or  720  to block  706 , where the option “Refill” is selected. The method then proceeds to block  708 , where the HOA code associated with the particular patient and particular prescription is entered. 
     The method then proceeds to decision diamond  710 , where it is determined if the patient has additional prescriptions to be refilled. If the patient has additional prescriptions to be refilled, the method proceeds to block  720 , where the next Prescription to be refilled is selected. The method then moves on to block  706 , where the ‘Refill’ option is selected; next, the method proceeds to block  708 , where the HOA code associated with the particular patient and particular prescription is entered. The method then returns to block  710 , and it is again determined if there are additional prescription to refill. 
     When there are no prescriptions left to refill, the method proceeds from decision diamond  710  to block  712 , where the label and billing information associated with the prescription order is verified. The method then proceeds to block  714  where the order is complete. 
     Referring now to  FIG. 8 , there is shown an illustrative prescription display comparison EPPA GUI  800 . The illustrative GUI  800  is configured to display an image of the scanned handwritten prescription for comparison and/or data entry. Information about a specific prescription in a prescription order may be entered into this illustrative GUI  800 . The scanned prescription  802  appears in the display window at the right of the GUI  800 . Information including patient name  804 , prescription number  806 , the name of the drug written on the prescription  810 , the name of the dispensed drug  812 , the number of days supply  814 , the quantity of tablets  816  that corresponds to the number of days supply, the HOA code  818 , number of remaining refills  820 , dosage quantity  822 , the quantity of tablets  824  that corresponds to the dosage quantity, the sig code(s)  826 , the prescriber name  828 , route of administration  830 , the prescription expiration date  832 , the date written  834 , and the date entered  836  may be viewed or entered into GUI  800 . Additionally, dosage instructions  838  and notes  840  may be viewed or entered into GUI  800 . In some embodiments, a user is able to make notations on the electronic image of the prescription as a removable layer such that the original prescription image can be viewed in the GUI with or without the notations. 
     With respect to  FIG. 9A , an overview of the prescription order verification process is shown. The verification process authenticates the accuracy of each prescription input. First, at block  902 , a patient&#39;s history is reviewed. The patient&#39;s history is compared to the plurality of prescription inputs to ensure therapeutic appropriateness. 
     As used herein, therapeutic appropriateness refers generally to the suitability of an integrated prescription order (or, the totality of prescription inputs) for a particular patient. Therapeutic appropriateness is determined by a number of factors. For instance, one important factor is whether a patient has a history of overuse or abuse of one or more drugs in the integrated order. Additionally, a patient&#39;s history of compliance (e.g., underuse or irregular use) as well as a reported effectiveness/ineffectiveness may be considered. An integrated order may be further evaluated to ensure that no medications in the order contain any substance known to cause an allergic reaction in the patient. A patient&#39;s medical diagnosis (e.g., recovering, terminally ill, advanced, intermediate, and early stages) may also aid in determining the therapeutic appropriateness of an integrated order. Therapeutic appropriateness may also depend on the likelihood of interaction—i.e., between several medications in an integrated order and/or between medications in the order and medications a patient is taking, or has recently taken, not associated with the order. Finally, the determination may include an evaluation of an integrated order to ensure that there are no therapeutic duplications or contraindications. 
     After it has been determined that an integrated prescription order is therapeutically appropriate, at block  904  it is determined whether there are any notes associated with a particular patient. These notes may describe changes to a patient regimen as well as any other pertinent information. If notes exist, the method proceeds to block  906 , where the notes are processed or read and any necessary action referred to in the notes is taken. Thereafter, the process continues to block  908 . If, on the other hand, there are no patient notes, the process simply advances to block  908 . Beginning with block  908 , the original handwritten prescription orders, or scanned images thereof, are compared to their associated prescription inputs to ensure that the prescription inputs are correct. More particularly, for each prescription input, the patient&#39;s name and date of birth are verified (block  910 ), the date that the prescription was written is verified (block  912 ), the drug strength, drug quantity, number of refills, and presence of a physician&#39;s signature are verified (block  914 ), the prescriber information is verified (block  916 ), the dispense as written (DAW) designation is verified (block  918 ), and, finally, the drug, the dosage, and the dosage frequency are verified (block  920 ). 
     If a prescription input can be verified at all of blocks  910 - 920 , the prescription input is verified and approved by a pharmacist at block  932 , a label is affixed to the back of the prescription order at  934 , a verification label is initialed by a pharmacist at  936 , and the prescription input is released to be filled by a filling machine at  938 . 
     If a prescription input cannot be verified at one or more of blocks  910 - 920 , an attempt may be made to correct the invalid prescription input at diamond  922 . Corrections are made by re-entering all of the invalid portion of the prescription input. If possible, the invalid prescription input is corrected at block  930 , whereafter the prescription input is verified and approved by a pharmacist at  932 , a label is affixed to the back of the prescription order at step  934 , a verification label is initialed by the verifying pharmacist at block  936 , and the approved prescription input is released to be filled by a filling machine at block  938 . 
     If, however, a prescription input cannot be corrected as specified above, clarification by the patient or prescriber may be required. If clarification is required, the method proceeds to block  924 , where all correct prescription inputs (i.e., those that do not require clarification) are verified by a qualified pharmacist. Thereafter, a label is affixed to the back of each associated prescription order and initialed by a pharmacist. Prescriptions may be clarified by contacting a patient or physician via email, facsimile, telephone, or any other such means; and, the inquiry may be made for additional or corrected information. Once the order is clarified, the method proceeds to block  936 , where the verification label for each prescription is initialed by a pharmacist. Finally, the clarified (and verified) order is released for filling at block  938 . 
     Referring to  FIGS. 9B through 9E , an embodiment of a verification GUI is displayed. The verification GUI comprises a software module and is configured, in broad terms, to display one or more prescription inputs for review by a pharmacist or, potentially, by a software module configured to verify and approve prescription inputs. As described above with reference to  FIG. 9A , a pharmacist may utilize the verification GUI as a means for comparing each prescription input to a hardcopy or scanned image of its associated prescription order. 
     To that end, referring now to  FIG. 9B , the verification GUI first comprises a patient/order selection interface  940 . The patient/order selection interface  940  comprises a plurality of tabs for performing various operations. More particularly, the interface  940  comprises a login tab  942 , an orders tab  944 , a verification tab  946 , an inspection tab  948 , a patient tab  950 , and a barcodes tab  952 . However, depending upon a user&#39;s (e.g., a pharmacist&#39;s) capability profile fewer than all of the tabs may be displayed on successful login. After the orders tab  944  is invoked, the software groups all outstanding prescriptions and displays a list  954  of all patients with outstanding orders. Referring to  FIG. 9C , selecting a patient from the list  954  of patients with outstanding orders populates the right hand side of the patient/order selection interface  940  with a list of all of the unverified and outstanding prescription orders  956  for the selected patient. Double clicking a patient name or selecting the Verify button  958  at the bottom right hand corner of the interface  940  populates and invokes the verification tab  946 . 
     Under the verification tab  946  the software displays all of the unverified prescription inputs. Here, there are two example prescription inputs,  960  and  962 . These are the prescription inputs that require verification and approval, as described above with reference to  FIG. 9 . More particularly, the verification GUI displays the information associated with each prescription input, whereby a pharmacist may compare the information displayed by the GUI to the information on, either, a hardcopy prescription order corresponding to the prescription input she is viewing, or a scanned image of the prescription order corresponding to the prescription input she is viewing. A checkbox  970  labeled “Show original prescription” permits the user to toggle between a first view ( FIG. 9D ) and a second view ( FIG. 9E ). Referring to  FIG. 9E , the second view juxtaposes each prescription input  960  and  962  with a scanned image of the associated prescription order  972  and  974 , respectively. 
     After verifying all the information in a particular prescription input, the pharmacist may approve the prescription input by checking a box,  964  and  966 , labeled “Approved” associated with the particular prescription input,  960  and  962  respectively. Alternatively, a pharmacist may determine that a prescription input is inconsistent with its associated prescription order, in which case the pharmacist may choose to leave the Approved box associated with the invalid prescription input unchecked. 
     The pharmacist may indicate that verification has been performed by entering an input into the GUI, for example, by activating a “Verification Complete” button  968  after she has reviewed all of the prescription inputs. Other means for entering an input using a GUI, such as ticking a checkbox, entering a note in a data field, or entering a signature on a touchscreen interface, may be used in the GUI to allow the pharmacist to indicate that a verification has been performed. Selecting the Verification Complete button  968  causes each of the prescription inputs associated with a patient and displayed in the Verification tab  946  to be grouped as an integrated order and assigned a unique ID number. Further, the approved prescription inputs are no longer shown under the Verification tab  946 , nor is the selected patient displayed under the Orders tab  944 , provided of course that the pharmacist approved all outstanding prescription inputs associated with the patient. 
     The patient compliant medicament dispensing containers described herein are available in many different styles, allowing patients to make decisions about the type of medicament packaging that will best suit their needs. Patient-selectable packaging for multiple medication compliance regimens allows a patient to choose a medicament container system on the basis of several factors, including ease of opening, childproofing features, number of tablets to be consumed daily, and desired dosage grouping (7-day or 30-day). 
     Many younger individuals take only a few prescription medications. Most of these patients are able to easily open any of the many types of packaging available. A primary concern for this type of patient may be portability and sturdy construction of the packaging. The compliance aspect may be very simple—the package may just make the medications more readily portable than needing to take several bottles of pills around AND having to remember whether one took them that day or not. Further, this type of patient may travel often, and may desire that medications are dispensed in smaller dosage groupings, such as a 7-day grouping, to avoid having to carry around medications for an entire month when only travelling for a few days. 
     Patients with small children may find it is important that the packaging is child-proof. The compliance aspect will also help ensure parents that their medications are safe from tiny hands, since missing medication would be easy to detect. 
     On the other end of the spectrum, a patient who possesses limited manual dexterity may need a container system that is easy to open or may require assistance to take medications. Patients who consume several tablets at frequent intervals throughout the day or having many prescriptions to manage may benefit from compliance packaging indicating when tablets have been consumed. For a patient living in an assisted living facility or utilizing a caregiver, a compliance container system facilitating ease of distinguishing one patient&#39;s medications from another&#39;s may be preferred. 
       FIG. 10  shows an illustrative patient interface, including package selection options. The illustrative GUI  1000  embodiment is configured to receive a prescription order, a direct order, or any such order related to medications, vitamins, supplements, herbs, oils, or any such substance that is associated with a particular patient. The illustrative GUI  1000  includes fields for the name of the patient  1002  and the patient&#39;s address  1004 . Additional information about the individual placing the order may also be requested, such as the individual&#39;s telephone number  1006  and email address  1008 . Information about the patient such as date of birth  1010 , height  1012 , weight  1014 , and sex  1016  can also provided to the illustrative GUI  100 . The user can input information about the patient&#39;s medical conditions  1020 , information about the patient&#39;s doctor  1022 , allergies  1024 , and current medications  1026  being taken by the patient. 
     Furthermore, the user may select specific ordering options such as the type of packaging to be used for the medication. For example, a plurality of single packages  1028  may be requested for multiple medications. Also, a multiple prescription package  1030  or “multi-script” package may be requested. The multiple prescription package may include a variety of user selectable options such as type of package, size of package, and child resistant packaging. The type of package may include a sleeved package or a spiral package as described below. Alternatively, the packaging may employ other packaging techniques such as grid packaging or the use of plastic bags. 
     Data fields are also provided for identifying the requested medications  1032  that include a description of the product  1034 , the dosage  1036 , the quantity  1038 , and the type of drug  1040 . The type of drug  1040  may include information about whether the drug is generic or name brand. If the product is available, the on-line ordering system may then provide a price  1042  for the product. A sub-total  1044  is then provided, and shipping costs  1046  are identified. A final order total  1048  is then presented to the user. The patient may then provide a card  1050  such as a credit card, a debit card or any other such information for conducting an on-line transaction. The name, the card number, the type of card and the expiration date of the card are requested in the illustrative embodiment. 
     Referring to  FIG. 11  there is shown a 30-day tablet regimen for the patient medication management system that uses the seven-day box. A patient medication management system  1100  provides a compliance packaging solution. The patient medication management system  1100  described herein provides a compliance package because, firstly, an action is required by the patient or caregiver that requires identifying the appropriate dosage period, e.g. morning, and selecting the appropriate pouch. Secondly, the patient opens the appropriate pouch and consumes the medication. Thirdly, the patient or caregiver records the consumption of the medication by removing or pressing the circular cuts. 
     The patient medication management system  1100  comprises a plurality of sealed pouches that are grouped into four separate strips  1102 ,  1104 ,  1106  and  1108 . The first strip  1102  is a seven day strip that covers the illustrative dates of Sep. 22, 2007 through Sep. 28, 2007 and the illustrative dosing period is the “morning.” In the illustrative embodiment, the dosage period is selected from the group of dosage period intervals consisting of a morning dosage interval, a noon dosage interval, an evening dosage interval, or a bedtime dosage interval. 
     The first strip  1102  is placed into the illustrative folded box  1110  that has the tablets corresponding to the first week of the 30-day regimen. The second strip  1104  is a seven day strip that covers the illustrative dates of Sep. 29, 2007 through Oct. 5, 2007. The dosing period remains the same, i.e. morning. The second strip  1104  is associated with folded box  1112  that houses the tablets corresponding to the second week of the 30-day regimen. The third strip  1106  is a seven day strip that covers the illustrative dates of Oct. 6, 2007 through Oct. 12, 2007 and, again, the dosing period is the morning. The third strip  1106  is associated with folded box  1114  that corresponds to the third week of the 30-day regimen. 
     The fourth strip  1108  includes a seven day grouping of pouches  1116  that covers the illustrative dates of Oct. 13, 2007 through Oct. 19, 2007; the dosing period remains the same, i.e. morning. Additionally, an empty pouch  1118  is included with the fourth strip  1108  that provides a reminder to place another order and an illustrative  800  number to assist in placing the refill order. Furthermore, a two day grouping of pouches  1120  covers the illustrative dates of Oct. 20, 2007 through Oct. 21, 2007. The fourth strip  1108  is associated with folded box  322  that houses the tablets corresponding to the fourth week of the 30-day regimen. Thus, the fourth strip  1108  includes nine pouches that complete the 30-day regimen. 
     Each of the strips  1102 ,  1104 ,  1106  and  1108  are placed in the corresponding folded box  1110 ,  1112 ,  1114  and  1122 , respectively. Each folded box or “primary container” is configured to receive at least seven pouches. Note, the terms folded box, assembled box, and “primary container” are used interchangeably though out this patent. Thus, each primary container is configured to receive at least seven pouches that correspond to the particular dosage period and the illustrative primary container is labeled with the dosage period corresponding to the medications. Additionally, each primary container may be labeled with the patient name and dosage period as described above. 
     Each folded box or primary container comprises a plurality of daily indicators corresponding to a seven-day period that are disposed on the primary container. The daily indicators provide a means for recording that the medications in the pouch have been taken. An illustrative embodiment of the daily indicators has been provided above that describes a plurality of circular cuts  1158  on the folded box. Each of the daily indicators is configured to indicate that the medications in the pouch have been taken, thereby providing a means for compliance packaging. 
     In the illustrative 30-day regimen, the sealed pouches associated with strips  1102 ,  1104 ,  1106  and  1108  include sealed pouches with a plurality of different tablets that correspond to different medications and/or vitamins. The different medications are associated with at least one prescription and each tablet includes an appropriate dosage consistent with the prescription. Each of the sealed pouches is labeled to show the medications in the pouch and labeled with a particular dosage period that includes at least one daily interval for consuming the medications in the pouch. 
     Referring to  FIG. 12  there is shown a label area on a pre-assembled blank  1290 . The information on label  1292  is located on the front face of the blank  190  and includes information that is associated with a particular patient. The label  1292  may be affixed separately as a separate label, printed on the blank  1210  in the label area, or any combination thereof. The label area includes the top wall  1212 , and top side flaps  1216   a  and  1216   b.    
     Referring to  FIGS. 13A-13B , there is shown an isometric view of the 30-day tablet dispensing container  1300 . In general, the illustrative 30-day tablet dispensing container is a foldable box that includes a top wall, a front side wall, a right-side wall, a back side wall, a left-side wall and a bottom wall. The top wall has one end fixedly couple to the foldable box and an opposite end that provides a foldable lid. The front side wall has a removable lid that is bordered by a plurality of perforations. The right-side wall abuts the front side wall and the top wall. The back side wall abuts the right-side wall and the top wall. The left-side wall abuts the top wall and is between the back side wall and the front side wall. The bottom wall abuts the front side-wall, the right-side wall, the back side, and the left-side wall. The container is formed to receive a plurality of pouches as described herein. 
     By way of example and not of limitation, the illustrative cardboard used to construct container  1300  includes an outer smooth layer of paper and a thick interior layer. The outer smooth layer may receive printed text or images using an illustrative laser printer, ink jet printer, or other such printing means. Additionally, the outer layer may also be configured to receive a label that is affixed thereto. 
     In the illustrative embodiment, a perforated, removable lid  1304  makes up a large portion of the front side wall  1306  and top wall  1302  of the illustrative container  1300 . The lid can be partially or completely removed in order to access the medicament pouches within the container  1300 . In one embodiment the lid  1304  may only occupy one wall such as the front side wall. In the illustrative embodiment, the lid occupies the front side wall  1306  and extends to the top wall  1302 . 
     The illustrative top wall  1302  has one end fixedly coupled to the foldable box and an opposite end that provides a foldable lid. A secondary label (not shown in exploded view) is configured to seal the foldable lid on the top wall. In the illustrative embodiment, the secondary label has a bar code and includes the time interval when the tablets should be administered or taken. In the illustrative embodiment, the secondary label  1375  visible on top wall  1302  of the container  1300  indicates the time period  1370 , the filling date  1374 , and the prescription start date  1376  listed above the perforations of lid  1304 . 
     Referring now to  FIGS. 14A-14B , a top view and a bottom view of a plurality of illustrative sealed multiple prescription containers  1420  is shown. Both views reflect that one of the containers  1421  comprises a tapered body container  1422  with a cavity for holding a plurality of tablets. The tapered body container  1422  allows a plurality of individual containers to be stacked for storage. Each container  1420  has a flanged top surface  1424  configured to be sealed with a lid  1426 . In certain embodiments, the tablet assembly may require individual containers that vary in depth depending on the amount of tablets needed to be dispensed at a specific time. While the depth of the individual containers may vary, the flanged top surface and collar remain constant for processing of different sized individual containers and for commonality with the assembly sleeve. 
     In one embodiment, the multiple prescription container assembly comprises a plurality of individual containers. In one illustrative embodiment, container  1421  is coupled to container  1428  with lid  1426 . The lid  1426  seals one or more containers. The sequential connection enables a linear configuration for the individual containers. 
     However, it should be noted that the quantity of containers in a multiple prescription assembly may vary as well as the interconnection configuration of the containers, e.g. a circular, an elliptical, polyhedral, etc. 
     In another embodiment, the plurality of multiple prescription containers are made from a single piece of moldable material having a plurality of indentations wherein each indentation is configured to form one container  1421  in the set of containers  1434 . At least one of the containers is configured to receive a first tablet associated with a first medication, and a second tablet associated with a second medication that is different from the first medication. The set of containers  1434  are connected to one another by frangible connections  1436  or perforations positioned within the flanged edge  1424  that are proximate to the adjacent container. The frangible connection  1436 , which is between containers, allows the containers to “break-away” from the set of containers  1434  in a sequential manner. Once the lids are attached and/or sealed to the top flanged surface  1424 , this sequential connection enables a linear configuration as described above. 
     Each container may also comprise a collar  1438  below the flanged edge  1424  that allows the containers to be stored in a stackable configuration. Stacking of the containers can also be performed with the collar  1438 . Each container may also comprise a bottom surface  1440  with at least one ridge  1442 . The ridge is useful in minimizing tablet-to-tablet collisions and avoiding medication sloughing off of a tablet due to collisions with other tablets. By limiting excessive movement of the tablets in each of the containers, the ridge or ridges on the bottom of the container(s) help preserve the integrity of the tablets within. The ridge may protrude outward from the bottom surface of the containers, or in other embodiments, may be formed by an indentation of the bottom surface. The ridge(s) may be configured as a square, rectangle, circle, and a plurality of parallel lines as well as other geometric shapes. 
     The illustrative set of containers  1434  comprises seven adjacent containers configured for sequential dispensing of the contents of each container. Sequential dispensing refers to individual containers being “dispensed one at a time,” which is different from being “cherry picked” from a grid of individual containers. The number of containers in a set of integrated containers may vary due to the prescription prescribed for the user. While the illustrative embodiment describes seven containers, a set of containers may comprise at least two containers to about 20 containers, and more preferably about 10 to about 14 containers. It is expected that most of the containers will be of similar size for ease of filling the containers, but in certain embodiments varying container sizes may be needed. The set of containers  1434  may be opaque but in preferred embodiments, the moldable material is sufficiently transparent for the user to see the contents of the containers. 
     The illustrative lid  1426  of container  1421  comprises a printing surface where unique prescription-specific information is displayed for each container. The information displayed on the printing surface may include, but is not limited to, the patient&#39;s name, the date and the day of the week the contained mixed dosage medications (tablets) are to be taken, as well as the time of day that the tablets are to be taken. The markings on the containers inform the patient and/or caregiver the time in which the contents of the container are to be taken in the proper sequence. In general, the lid stock comes from a roll and the appropriate amount of lidstock is released from the roll to accommodate the designated number of containers to be sealed. For a thermoformed container, using polypropylene for the material for the lid stock, an unsealed area of lid film is generally used to help in the peeling of the lid. The breakaway tab  1432  on the illustrative container  1421  gives the user something to hold onto and is a useful feature to a container that is manufactured by injection molding with plastics like polyethylene or styrene. 
     Referring to  FIG. 15  there is shown an exploded isometric view of the multiple prescription container assembly  1550  prior to being assembled. The exploded view also shows a top tab  1554  on the top surface  1556  of the sleeve which holds the end container  1558  by catching the rectangular void made by one of the indentations  1560 . When the user pushes down the sleeve tabs  1562 , the set of sealed containers are released and the top tab  1554  is disengaged from the containers. The end container  1558  can be slid out of the dispensing sleeve  1552  if there are no other child protective features, and the top tab latches on to the next indentation (not shown). The user then can break the frangible connection  1564  and remove the container. This two-step process of holding tabs  1562  and pulling on the end of the sealed containers is a “child safety” feature. It shall be appreciated by those skilled in the art that certain embodiments can be made to conform to a more senior-friendly solution that is described in further detail below. 
     Additionally, there is shown a notch  1563  that is configured to be fit into an illustrative cavity that is a square-shaped perimeter  1565  and receives a notch similar to notch  1563 . The notch  1563  permits two dispensing sleeves to “snap” together. The square shaped perimeter  1565  is located on the edge of the dispensing sleeve  1552  and has a square cut and a lip. Printed material  366  may be attached to the top surface  1556  of the dispensing sleeve  1552 . Additional information about the prescription or other patient data can also be placed on the dispensing sleeve  1552 . The dispensing sleeve  1552  may also comprise a surface for printable indicia, and the printable indicia may include patient data as well as prescription information. 
     Referring to  FIG. 16  there is shown an isometric view of the multiple prescription container assembly  1650 . The end container  1635  can be slid out of the dispensing sleeve  1668  if there are no other child protective features, and the top tab latches on to the next indentation (not shown). The user then can break the frangible connection and remove the container. This two-step process of holding tabs  1680   a  and  1680   b  and pulling on the end of the sealed containers is a “child safety” feature. It shall be appreciated by those skilled in the art that certain embodiments can be made to conform to a more senior-friendly solution that is described in further detail below. 
       FIG. 17  is an illustrative top view of multiple sleeves coupled to one another and depicting the sequential dispensing of a container. In this illustrative example, the multiple prescription container assembly is for patients that must take multiple medications more than once a day. The multiple prescription container assembly  1720  comprises a plurality of thermoformed (or molded) sets of sealed container  1722   a ,  1722   b , and  1722   c  that are heat sealed with a laminated lid  1724   a ,  1724   b , and  1724   c , respectively. Each container within the set of containers  1722   a ,  1722   b , and  1722   c  contains the required medications that have been prescribed for a particular time. The containers are separated by perforations as described above. In the illustrative embodiment, each container contains printed markings  1726  that identify the medications contained therein, and may also indicate the patient&#39;s name, and, most importantly for the purposes of this embodiment, the day and the time of day that the medications are to be taken. 
     In the illustrative embodiment of  FIG. 17 , each container is dedicated solely to a particular time of day. In the illustrative example, the set of containers  1722   a  are taken in the morning, the set of containers  1722   b  are taken at approximately noon, and the set of containers  1722   c  are taken in the evening. Thus, it is possible to have a plurality of containers for each day of the week so that each container has the proper dosage that is to be taken at a particular time of day. In this illustrative embodiment, the patient is supplied with a complete set of containers for a particular week for a specific time of day. 
     Each individual container within each set of containers is to be taken at the correct, prescheduled time each day as marked on each container. The multiple prescription container assembly  1720  may be provided to the patient or caregiver as three separate sets of containers enclosed in three separate dispensing sleeves. The patient or caregiver can interlock the three separate dispensing sleeves  1728   a ,  1728   b , and  1728   c.    
       FIG. 18A ,  FIG. 18B  and  FIG. 19  show one embodiment of a medicament container or cup  1840  for holding medication in the form of tablets, caplets, pills, capsules, powders, liquids, gels, suppositories or other form of medication. The medication within containers  1840  may be prescription medication, vitamins, supplements, herbal formulations, or combinations thereof, intended to be ingested by or administered to a patient to improve the patient&#39;s health or well being. The medicament container  1840  comprises a tapered body  1860  with a cavity  1870  for holding a plurality of pills or other medication. The container  1840  includes a flanged top surface or edge  1850  configured to be sealed with a lid (not shown). Container  1840  may also include a frangible or removable top or lid (not shown) adjacent to flange  1850 . Breaking or removing the top allows a user to access the medication therein. The top may be transparent to allow a user to see the contents of container  1840 . 
     Generally, the flanged top edge  1850  of container  1840  comprises a first side  1880  and second  1890  side which are configured such that flange  1850  interacts with the spiral grooves or tracks of a packaging system such that container  1840  can slide or otherwise move along the tracks. The flange top edge  1850  further comprises a third side  1900  and fourth side  1910 . When containers  1840  are arranged in a chain, side  1900  of one container  1840  is positioned adjacent side  1910  of an adjacent container (except for the first container  1840  in the chain). Top edge sides  1900  and  1910  of adjacent containers  1840  can be connected to one another by a frangible interface  1855 . The containers  1840  can then be detached from one another by breaking the connector  1855 . 
     Each container  1840  includes protrusions or ribs  1920 A,  1920 B on the exterior of tapered body  1860  of the container  1840 . Ribs  1920 A and  1920 B each support a tab section  1930 A and  1930 B respectively, with tabs  1930 A,  1930 B located adjacent top flange  1850 . The tabs  1930 A and  1930 B are configured to interact with sprocket teeth on compliance wheel  1960  to allow the container  1840  to be moved as teeth  1960  apply force to tabs  1930 A,  1930 B when wheel  1970  is rotated. The ribs  1920 A and  1920 B and tabs  1930 A and  1930 B may in many embodiments be configured to aid in childproofing the packaging system, as described further below. Counter-clockwise rotation of wheel  1960  results in teeth  1970  applying force to tab  1920 A to move container  1840  in one direction, while clockwise rotation of wheel  1950  results in teeth  1970  applying force to tab  1920 AB to move container  1840  in the opposite direction. 
     The tapered body  1860  of each container  1840  further comprises an arcuate or concave portion  1940  positioned between the ribs  1920 A and  1920 B. Top flange  1850  includes an arcuate or concave portion adjacent to the concave portion  1940  of container body  1860 . The configuration of the concave portions  1940  and  1950  of the container  1840  allows the teeth  1970  of compliance wheel  1960  to engage the tab portions  1930 A,  1930 B of the container  1840  without interference from the tapered body  1860  of the container  1840 . 
     Referring now to  FIG. 20 , there is shown still another embodiment of a medication packaging system  2000 , wherein like reference numbers are used to denote like parts. The spiral medication packaging systems may be modular and attachable to each other to form extensible or scalable medication packaging systems in a similar manner as described above. The apparatus  2000  includes a child proofing barrier element  2010  movably mounted in wall  2020  adjacent to opening  2030 . Barrier  2010  is movable between an open position (as shown in  FIG. 20 ) that allows container  1840  to pass through opening  2030 , and a closed position (not shown) wherein container  1840  is blocked by barrier  2010  such that container  1840  cannot exit or be removed through opening  2030 . A spring or bias element (not shown) may be operatively coupled to barrier  2010  such that barrier  2010  remains in the closed position unless a user applies sufficient force to barrier  2010  to overcome the bias and move barrier  2010  to the open position. 
     In the embodiment of  FIG. 20 , barrier  2010  includes an arcuate or curved lip  2040  that is configured to cover and block corners  2050  of container  1840  when barrier  2010  is in the closed position, and which allows corners to pass over or clear lip  2040  when barrier is in the open position as shown in  FIG. 20 . 
     To operate the apparatus  2000 , a user simultaneously pushes on or depresses barrier  2010  to the open position while advancing compliance wheel  2060  to move container  1840  through opening  2030 . When the container  1840  has passed through opening  2030 , the container  1840  is detached and removed from the apparatus  2000 , and the barrier  2010  is released to return to the closed position. The next container  1840  is then blocked by barrier  2010  from exiting the apparatus  2000  until the child proofing barrier  2010  is again depressed or moved to the open position. Simultaneous manipulation of the compliance wheel  2060  and barrier  2010  are sufficiently difficult that small children are unable to access the medication within apparatus  2000 . 
     Referring now to  FIG. 21  there is shown an isometric view of the spiral medication packaging system  2000  in accordance with the invention, wherein like reference numbers denote like parts. The apparatus  2100  includes transparent outer facings or housing elements. Housing element  2110  is visible on the apparatus  2100  in  FIG. 21 . 
     Operation of the child proof barrier  2010  will be more fully understood by making reference to  FIGS. 22 and 23 , wherein like reference numbers denote like parts.  FIGS. 22 and 23  show a portion of a modular system  2200  wherein the child proof barrier  2010  in packaging system  2200 B is shown in the closed position, and wherein the barrier  2010  is shown in the open position in adjacent packaging system  2200 A. In the closed position as shown in system  2200 B, arcuate lip  2040  of barrier  2010  blocks the lower corners of container  1840  to prevent container  1840  from being removed through opening  1830 . In the open position shown in system  2200 A, the lower corners  2050  of container  1840  are clear of lip  2040  and container  1840  may be advanced through opening  2030  by operation of compliance wheel  2110 . The arcuate shape of lip  2040  accommodates a user&#39;s finger and facilitates manipulation of barrier  2010  and container  1840 . 
     During the filling process, integrated labeling is produced and affixed to the medicament containers. Integrated labeling is a unique feature of the system and methods described herein. Integrated labeling includes information about the patient, the medications the patient is taking, and other illustrative information. Integrated labeling may include extensive labeling on the primary medicament containers (such as the pouches or medicament cups that directly hold the medication. One illustrative example of this labeling is shown in  FIGS. 24A-24C . Integrated labeling may also include extensive labeling on the secondary container that may hold a plurality of primary containers, as shown in  FIGS. 25A-25G . Integrated labeling may also include a Patient Information booklet. Illustrative integrated labeling is described in more detail below. 
     Referring to  FIG. 24A  there is shown a group of seven separable pouches, wherein each pouch comprises a plurality of different tablets. The separable sealed pouches have been grouped into a collection of seven pouches  2490  that correspond to a seven day supply of medications. A plurality of sealed pouches that is grouped is also referred to as a “strip,” and the terms “strip,” “group of pouches,” and “strip of pouches” is used herein interchangeably. 
     Referring to  FIG. 24B  there is shown an exploded view of the illustrative front side of one of the sealed center cut pouches  2492  that is included in the strip of pouches  2490 . The exploded view shows that a variety of data fields that are printed on the front of each pouch. In general, the data fields provide information corresponding to each tablet within the pouch. The data fields includes: the name of the patient  2494   a ; the date the tablets should be consumed  2494   b ; the time of day the tablets should be taken 2494c; the name of the prescribed medication  2494   d ; the name of the corresponding generic  2494   e ; the dosage  2494   f ; and the prescription number  2494   g . Additionally, an expiration date  2494   h  is included that identifies the medications should not be taken after the expiration date. 
     Referring to  FIG. 24C  there is shown an exploded view of the illustrative back side of the pouch  2492  in  FIG. 24B . The data fields include: the name of patient  2496   a ; a bar code  2496   b ; the address of the facility that filled the pouches with tablets  2496   c ; and the telephone number  2496   d  for additional information. The illustrative bar code associates the tablets in the foldable box with a particular patient. The illustrative seven-day strip  2490  is then placed in an illustrative seven-day container. These illustrative containers are then placed in a secondary container. 
     Referring to  FIGS. 25A-25G  there is shown an illustrative label of the type that would be affixed to a secondary container. The label  2500  may be affixed separately or the label may be printed directly on the cardboard or may be printed as a label that is separately affixed. 
     The illustrative label  2500  comprises a plurality of printed text that may include: the patient&#39;s name  2540 , the interval during which the medications are taken, e.g. morning, a picture of the patient  2542 , patient number  2544 , order number  2546 , a list of precautions  2548 , a listing of the medications  2550 , a listing of the time interval for taking the medications  2552 , a prescription number  2554 , quantity of tablets  2556  per prescription, quantity of refills  2558 , length of prescription  2560 , the prescribing physician  2562 , the manufacturer of the tablets  2564 , and the lot number  2566  corresponding to each tablet. Additionally, a picture  2568  of each tablet is provided and the dosage concentration  2570  is provided for each medication. Information about the associated generic drug  2572  is also provided. Furthermore, an expiration date may also be provided for each tablet or for each prescription. Further still, information regarding the generic or trademarked name of the medication may be provided, manufacturer information, corresponding “expiration dates,” personal contact information, physician contact information, insurance information, and other such information associated with the tablets in each container. 
     Further yet, a bar code  2574  provides a means for associating the medications in the foldable box with a particular patient. Alternative means for associating the medications in the box to the patient include, by way of example but not of limitation, the patient&#39;s name, a serial number, a radio frequency identification (RFID) tag, or any other such method for associating an individual with a particular item. 
     Integrated labeling may also include a Patient Information Booklet that includes a plurality of information relating to the patient&#39;s prescription order. The Patient Information Booklet may include specific information regarding the medications that a patient is taking, and may also include information specific to the patient, including information about the disease(s) for which the patient is being treated, or information about the mechanism of one or more drugs in the order as it pertains to the specific patient. 
     Referring now to  FIG. 26 , an illustrative GUI  2600  is shown. Visible in the display window  2601  is a portion of the drug summary that will appear in the patient information booklet that is associated with a patient&#39;s prescription order. The patient name  2602  appears near the top of the summary page. Illustrative drug descriptions  2604  and  2606  include information such as drug name  2608 , dosage  2610 , dosage form  2612 , quantity  2614 , administration information  2616 , number of refills  2618 , expiration date  2620 , prescriber name  2622 , and prescription number  2624 . 
     The inspection process must be performed at about the same time as the labeling and filling processes. The inspection not only verifies that each prescription in the order is correctly filled; it also verifies that the labeling information is correct and is correctly associated with the appropriate patient and prescription order. Further, since the prescription order will typically be dispensed in a compliance container similar to those described above, the labeling information must also accurately reflect the time period for administration of each drug. Further still, the integrated labeling must also accurately reflect the patient information. All of this information must be confirmed during the inspection process. 
     One embodiment of the inspection process is shown in the illustrative flowchart of method  2700  in  FIG. 27 . At block  2702 , the inspection process is initiated by scanning a bar code of the label affixed to any strip, after the inspection tab is selected in EPPA. The inspection process includes an initial inspection, which is a secondary validation of drug name, strength, directions, and patient name, at block  2704 . The method then proceeds to decision diamond  2706 , where it is determined if all information is correct. If any of the information is incorrect, the method proceeds to block  2744 , where the package is removed from the inspection process and placed into the package recovery process. 
     If the information is correct, the method proceeds to block  2708 , where the approval of each prescription individually and of the entire prescription order takes place. The method then proceeds to block  2710 , where any strip in the order is scanned and the patient&#39;s name is verified. Moving on to decision diamond  2712 , if the patient&#39;s name is not correct, the method proceeds to block  2744 , where the package is removed from the inspection process and placed into the package recovery process. 
     If the patient&#39;s name is correct, the method proceeds to block  2714 , where a visual inspection takes place to verify that each pouch or cup holds the correct number of tablets. Moving on to decision diamond  2716 , if the number of tablets is not correct, the method proceeds to block  2744 , where the package is removed from the inspection process and placed into the package recovery process. The visual inspection may include visual inspection by a qualified operator, machine-vision techniques, or some combination thereof. 
     If the number of tablets in each pouch or cup is correct at decision diamond  2716 , the method proceeds to block  2718 , where each type of tablet that appears in the pouches or cups is matched to a portion of its integrated labeling, verifying that the tablets are the correct ones that correspond to the prescription order. Moving on to decision diamond  2720 , if one or more tablet imprints do not match, the method proceeds to block  2744 , where the package is removed from the inspection process and placed into the package recovery process. 
     If the tablet imprints match, the method proceeds to block  2722 , where the quantity of each tablet type in each cup or pouch is verified. Moving on to decision diamond  2724 , if one or more cups or pouches do not contain the correct quantity of each tablet, the method proceeds to block  2744 , where the package is removed from the inspection process and placed into the package recovery process. 
     If the quantities of each drug tablet in each pouch or cup are correct, the method proceeds to block  2726 , where the information on the integrated labeling is verified, and the print quality is confirmed to be good. Moving on to decision diamond  2728 , if any label information is incorrect, or if the print quality is unacceptable, the method proceeds to block  2744 , where the package is removed from the inspection process and placed into the package recovery process. 
     If the integrated label information is correct and the label information is determined to be of sufficient print quality, the method proceeds to block  2730 , where the inspected strip is accepted. The method then proceeds to decision diamond  2732 , where it is determined if there are additional strips to process for the prescription order. If there are additional strips to process, the method returns to block  2710 , and each additional strip is processed in the manner described above, from block  2710  to decision diamond  2732 . 
     Once there are no more strips to process at decision diamond  2732 , the method proceeds to block  2734 , where the labels are affixed to the secondary containers, and to the pouches or cups if necessary. The method then proceeds to block  2736 , where all items are placed in a tote for further processing, including folding, loading, and/or sealing, as necessary. 
     The method then proceeds to block  2738 , where the handwritten prescription is initialed by a qualified pharmacist. The method then proceeds to block  2740 , where the initialed handwritten prescriptions corresponding to the prescription order are filed. The method then proceeds to block  2742 , where the tote assembly is forwarded to the boxing station. 
     The inspection method described above is illustrative and may vary as to details. For example, instead of inspecting each strip one at a time before strips are forwarded to the boxing station, as described above in the method  2700 , the qualified pharmacist may instead box each strip as soon as the label is verified, and then place the box into the shipping container. Likewise, the qualified Pharmacist may place the strip into a spiral package or into another type of compliance container or apparatus instead of a box. 
     Alternatively, the inspection method may include printing the exterior integrated labeling that is subsequently affixed to the box before the strips are approved, but after the order has been verified. Then, the strip inspection takes place, and each strip is matched to the integrated label associated with each box as the strip itself is verified.