Patent Publication Number: US-2010112568-A1

Title: Methods and kits for diagnosis of multiple sclerosis in probable multiple sclerosis subjects

Description:
FIELD AND BACKGROUND OF THE INVENTION 
     The present invention, in some embodiments thereof, relates to genetic markers which are differentially expressed between subjects diagnosed with probable multiple sclerosis (MS) which further develop the definite diagnosis of MS and control subjects, more particularly, but not exclusively, to methods and kits using same for determining the probability of a subject diagnosed with probable multiple sclerosis to develop a definite diagnosis of multiple sclerosis and for treating subjects diagnosed with probable multiple sclerosis. 
     Multiple sclerosis (MS) is the most common central nervous system (CNS) disease affecting young adults (disease onset between 20 to 40 years of age), and the third leading cause for disability after trauma and rheumatic diseases. Disease prevalence in USA is 120/100,000, (250,000 to 350,000 cases), and in Israel about 30/100,000. MS is a multifactorial disease that develops in genetically predisposed subjects exposed to yet undefined environmental factors and which results in irreversible neurological disability. 
     The diagnosis of MS is defined primary by clinical terms and relies on a combination of history, neurological examination and ancillary laboratory and neuro-imaging studies. Typically, at onset of MS, an otherwise healthy person presents with the acute or sub-acute neurological symptomatology (attack). The symptoms usually remain for several days to few weeks, and then partially or completely resolve. The neurological symptoms are accompanied by demyelinating lesions on brain MRI. Thus, the laboratory diagnosis of probable MS is based on: 1) Cerebro-spinal fluid (CSF) evaluation of IgG synthesis, oligoclonal bands; and 2) MRI of the brain and spinal cord. After a period of remission, a second attack will occur. During this period between the first and second attacks, the patient is diagnosed as probable MS. Only when the second attack occurs, the diagnosis of clinically definite MS is established. 
     In about 85% of the patients with definite diagnosis of MS, the disease course is relapsing-remitting definite MS (RRMS), which is characterized by attacks during which new neurological symptoms and signs appear, or existing neurological symptoms and signs worsen. Usually an attack develops within a period of several days, lasts for 6-8 weeks, and then gradually resolves. During an acute attack, scattered inflammatory and demyelinating CNS lesions produce varying combinations of motor, sensory, coordination, visual, and cognitive impairments, as well as symptoms of fatigue and urinary tract dysfunction. The outcome of an attack is unpredictable in terms of neurological squeal, but it is well established that with each attack, the probability of complete clinical remission decreases, and neurological disability and handicap are liable to develop. In about 15% of patients the disease has a primary progressive course, characterized by gradual onset of neurological symptoms that progress over time. In a subset of patients (about 40%), the disease has a secondary progressive course, i.e., it is first characterized by relapses and remission and then gradually progresses (See  FIGS. 4   a - c ). The only course of MS in which treatment was effectively established is RRMS. Various immunomodulatory drugs have been shown to reduce the number and severity of acute attacks, and thereby to decrease the accumulation of neurological disability. 
     The main pathologic findings in MS are the presence of infiltrating mononuclear cells predominantly T lymphocytes and macrophages that surpass the blood brain barrier and induce an active inflammation within the brain and spinal cord, attacking the myelin and resulting in gliotic scars and axonal loss. These inflammatory (acute and chronic) processes can be visualized by brain and spinal cord magnetic resonance imaging (MRI) as hyperintense T2 or hypointense T1 lesions. Thus, MRI examination can serve for the diagnosis of the disease and as a surrogate marker to follow disease activity by measuring lesion load within the brain. 
     The etiology of MS is still unknown. The pathogenesis of MS involves autoimmune mechanisms associated with autoreactive T cells against myelin antigens. It is well established that not one dominant gene determines genetic susceptibility to develop MS, but rather many genes, each with different influence, are involved. The initial pathogenic process that triggers the disease might be caused by one group of genes, while other groups are probably involved in disease activity and progression (5, 6). 
     In a previous epidemiological study the present inventors have shown that 57.6% of patients with probable MS experience a second attack within one year from onset, and thus convert to definite MS (7). In other studies, the progression to clinically definite MS in patients with an abnormal brain MRI was 49% and 65% in the first 5 years, 41% and 68% within 2 years, and 24% and 45% within 1 year (8, 9, respectively). Prediction of disease progression rate is especially important during the initial stage, when patients first present with neurological symptomatology and are defined to suffer from probable MS. At this early stage the immunological process of epitope spreading which is associated with exposure of the immune system to myelin antigens is still limited and significant disability has not yet developed. 
     The potential application of DNA microarray technology for understanding neurological disorders was discussed in a recent review (12). In MS, microarray analysis of brain lesions and brains of mice with experimental allergic encephalomyelitis (EAE)—the experimental animal model of MS —identified genes that contribute to lesion pathology (13). Similarly, different expression of transcribed genes encoding inflammatory cytokines was demonstrated in acute inflammatory brain lesions compared with ‘silent’ lesions without inflammation, using a large-scale gene microarray analysis (14). 
     In the peripheral blood of MS patients, simultaneous inhibitory and stimulatory effects of inflammatory T cells and macrophages reflect their potential role within the ongoing autoimmune response was reported. Analysis of the expression pattern in peripheral blood mononuclear cells (PBMC) obtained from MS patients during a stable clinical remission revealed 34 genes out of more than 4000 tested that were significantly different from controls (15). In a previous study by the present inventors (16) PBMC gene expression pattern of 26 RRMS patients and 18 healthy subjects demonstrated significantly different pattern of 1109 genes between patients and healthy subjects. This signature contains genes that implicate the underlying processes involved in MS pathogenesis including T-cell activation and expansion, inflammation and apoptosis. To determine disease stage related gene expression signatures MS patients were evaluated during an acute relapse and in remission (16; PCT Pub. No. WO03081201A2, EP1532268A2, AU3214604AH, US20060003327A1, to the present inventors). This analysis demonstrated 721 differentiating genes including genes that play a regulatory role in epitope spreading and in macrophage recruitment to the inflammatory injury. Apoptotic-related genes such as cyclin G1 (CCG1)—the mediator of p53-dependent apoptosis and the caspases 2, 8 and 10 were significantly down-expressed. 
     SUMMARY OF THE INVENTION 
     According to an aspect of some embodiments of the present invention there is provided a method of determining a probability of a subject diagnosed with probable multiple sclerosis to develop definite multiple sclerosis, comprising determining in a cell of the subject a level of expression of at least one polynucleotide sequence selected from the group consisting of SEQ ID NOs:4, 16, 5, 56, 20, 3, 1, 10, 57, 24, 14, 49, 13, 37, 6, 47, 50, 21, 46, 8, 26, 2, 15, 51, 44, 19, 17, 25, 33, 48, 36, 34, 12, 29, 23, 11, 45, 53, 41, 40, 31, 58, 27, 43, 35, 30, 52, 55, 7, 9, 42, 28, 54, 32, 22, 18, 38, and 39, wherein an alteration above a predetermined threshold in the level of expression of the at least one polynucleotide sequence in the cell of the subject relative to a level of expression of the at least one polynucleotide sequence in a reference cell is indicative of the probability of the subject diagnosed with probable multiple sclerosis to develop definite multiple sclerosis. 
     According to an aspect of some embodiments of the present invention there is provided a method of treating a subject diagnosed with probable multiple sclerosis, comprising: (a) determining in a cell of the subject a level of expression of at least one polynucleotide sequence selected from the group consisting of SEQ ID NOs:4, 16, 5, 56, 20, 3, 1, 10, 57, 24, 14, 49, 13, 37, 6, 47, 50, 21, 46, 8, 26, 2, 15, 51, 44, 19, 17, 25, 33, 48, 36, 34, 12, 29, 23, 11, 45, 53, 41, 40, 31, 58, 27, 43, 35, 30, 52, 55, 7, 9, 42, 28, 54, 32, 22, 18, 38, and 39, wherein an alteration above a predetermined threshold in the level of expression of the at least one polynucleotide sequence in the cell of the subject relative to a level of expression of the at least one polynucleotide sequence in a reference cell is indicative of a probability of the subject diagnosed with probable multiple sclerosis to develop definite multiple sclerosis, and; (b) selecting a treatment regimen based on the probability; thereby treating the subject diagnosed with probable multiple sclerosis. 
     According to an aspect of some embodiments of the present invention there is provided a kit for determining a probability of a subject diagnosed with probable multiple sclerosis to develop definite multiple sclerosis, comprising no more than 500 isolated nucleic acid sequences, wherein each of the isolated nucleic acid sequences is capable of specifically recognizing at least one polynucleotide sequence selected from the group consisting of SEQ ID NOs:4, 16, 5, 56, 20, 3, 1, 10, 57, 24, 14, 49, 13, 37, 6, 47, 50, 21, 46, 8, 26, 2, 15, 51, 44, 19, 17, 25, 33, 48, 36, 34, 12, 29, 23, 11, 45, 53, 41, 40, 31, 58, 27, 43, 35, 30, 52, 55, 7, 9, 42, 28, 54, 32, 22, 18, 38, and 39. 
     According to an aspect of some embodiments of the present invention there is provided a probeset comprising a plurality of oligonucleotides and no more than 500 oligonucleotides wherein each of the plurality of oligonucleotides is capable of specifically recognizing at least one polynucleotide sequence selected from the group consisting of SEQ ID NOs:4, 16, 5, 56, 20, 3, 1, 10, 57, 24, 14, 49, 13, 37, 6, 47, 50, 21, 46, 8, 26, 2, 15, 51, 44, 19, 17, 25, 33, 48, 36, 34, 12, 29, 23, 11, 45, 53, 41, 40, 31, 58, 27, 43, 35, 30, 52, 55, 7, 9, 42, 28, 54, 32, 22, 18, 38, and 39. 
     According to some embodiments of the invention, the kit further comprising a reference cell. 
     According to some embodiments of the invention, each of the isolated nucleic acid sequences or the plurality of oligonucleotides is bound to a solid support. 
     According to some embodiments of the invention, the plurality of oligonucleotides are bound to the solid support in an addressable location. 
     According to some embodiments of the invention, the reference cell is of an unaffected subject. 
     According to some embodiments of the invention, the alteration is upregulation of the expression level of the at least one polynucleotide sequence in the cell of the subject relative to the reference cell, whereas the at least one polynucleotide sequence is selected from the group consisting of SEQ ID NOs:32-58. 
     According to some embodiments of the invention, the probability of the subject diagnosed with probable multiple sclerosis to develop definite multiple sclerosis is higher than about 75%. 
     According to some embodiments of the invention, the alteration is downregulation of the expression level of the at least one polynucleotide sequence in the cell of the subject relative to the reference cell, whereas the at least one polynucleotide sequence is selected from the group consisting of SEQ ID NOs:1-31. 
     According to some embodiments of the invention, the probability of the subject diagnosed with probable multiple sclerosis to develop definite multiple sclerosis is higher than about 75%. 
     According to some embodiments of the invention, detecting the level of expression is effected using an RNA detection method. 
     According to some embodiments of the invention, the kit further comprising at least one reagent suitable for detecting hybridization of the isolated nucleic acid sequences and at least one RNA transcript corresponding to the at least one polynucleotide sequence selected from the group consisting of SEQ ID NOs:4, 16, 5, 56, 20, 3, 1, 10, 57, 24, 14, 49, 13, 37, 6, 47, 50, 21, 46, 8, 26, 2, 15, 51, 44, 19, 17, 25, 33, 48, 36, 34, 12, 29, 23, 11, 45, 53, 41, 40, 31, 58, 27, 43, 35, 30, 52, 55, 7, 9, 42, 28, 54, 32, 22, 18, 38, and 39. 
     According to some embodiments of the invention, the kit further comprising packaging materials packaging the at least one reagent and instructions for use in determining the probability of the subject diagnosed with probable multiple sclerosis to develop definite multiple sclerosis. 
     According to some embodiments of the invention, the at least one polynucleotide sequence is as set forth by the polynucleotide sequences of SEQ ID NOs:4, 16, 5, 56, 20, 3, 1, 10, 57, 24, 14, 49, 13, 37, 6, 47, 50, 21, 46, 8, 26, 2, 15, 51, 44, 19, 17, 25, 33, 48, 36, 34, 12, 29, 23, 11, 45, 53, 41, 40, 31, 58, 27, 43, 35, 30, 52, 55, 7, 9, 42, 28, 54, 32, 22, 18, 38, and 39. 
     According to some embodiments of the invention, the cell of the subject is a blood cell. 
     According to some embodiments of the invention, wherein said detecting said level of expression is effected using a protein detection method. 
     Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, suitable methods and materials are described below. In case of conflict, the patent specification, including definitions, will control. In addition, the materials, methods, and examples are illustrative only and not intended to be limiting. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       The invention is herein described, by way of example only, with reference to the accompanying drawings. With specific reference now to the drawings in detail, it is stressed that the particulars shown are by way of example and for purposes of illustrative discussion of the preferred embodiments of the present invention only, and are presented in the cause of providing what is believed to be the most useful and readily understood description of the principles and conceptual aspects of the invention. In this regard, no attempt is made to show structural details of the invention in more detail than is necessary for a fundamental understanding of the invention, the description taken with the drawings making apparent to those skilled in the art how the several forms of the invention may be embodied in practice. 
       In the drawings: 
         FIGS. 1   a - b  depicts the most informative genes differentially expressed between probable MS and healthy subjects.  FIG. 1   a —Infogramm of 554 most informative genes (listed in Table 1) discriminated between probable MS patients (N=28) and healthy subjects (N=10); Each row represents a gene and each column represents a patient&#39;s sample.  FIG. 1   b —PCA analysis demonstrating only two classification errors (marked by circles; 5%) using the 554 most informative genes. Blue dots—healthy subjects, red dots—probable MS patients; 
         FIGS. 2   a - b  depicts the most informative genes differentially expressed between probable MS patients that converted to definite MS during a 2-year follow-up period and healthy subjects.  FIG. 2   a —Infogramm of the 1517 most informative genes (listed in Table 2) that discriminated between probable MS patients (N=12) that converted to definite MS during a 2-year follow-up period and healthy subjects (N=11); Each row represents a gene and each column represents a patient&#39;s sample. All genes passed FDR criteria at p&lt;0.03 and 8 genes passed Bonfferoni correction at p&lt;3.2×10 −5 .  FIG. 2   b —PCA applied to the 1517 most informative genes resulted in two clusters, healthy subjects (blue dots) and probable MS patients (red dots) with no classification errors (0 classification errors). 
         FIG. 3  is a Van-diagram demonstrating intersecting genes between probable which further developed a definite diagnosis of MS (the 1517 genes listed in Table 2 which differentiate between probable patients that developed to definite MS during 2 years follow up and healthy controls) and definite (the 722 genes listed in Table 4 which differentiate between MS patients with a definite diagnosis of MS, i.e., after at least the second neurological attack and healthy controls) PBMC gene expression signatures. Note that the 58 intersecting genes (listed in Table 5) share the same expression pattern, i.e., either upregulation or downregulation relative to control subjects in both subjects diagnosed with probable MS which further developed definite MS within a 2-year period (i.e., probable MS subjects who develop clinical symptoms/MRI pattern which fit the diagnosis of a definite MS) and the subjects diagnosed with definite MS (i.e., an expression pattern determined in subjects with a definite diagnosis of MS); 
         FIGS. 4   a - c  depict the various multiple sclerosis subtypes.  FIG. 4   a —a flow chart of the MS clinical subtypes. A subject diagnosed with probable MS can develop a diagnosis of definite MS (in about 85% of the cases) during 5 years follow up period or remain diagnosed as probable MS (in 15% of the cases). Of the subjects diagnosed with definite MS, 85% exhibit a disease course of relapsing-remitting MS (RRMS) and about 15% exhibit a primary progressive course of disease. Of the patients developed RRMS, 40% will develop a secondary progressive MS course.  FIG. 4   b  schematically illustrates the disease courses of RRMS or secondary progressive MS.  FIG. 4   c  schematically illustrates the disease course of primary progressive MS with or without attacks/remission periods. 
     
    
    
     DESCRIPTION OF SPECIFIC EMBODIMENTS OF THE INVENTION 
     The present invention, in some embodiments thereof, relates to genetic markers which are differentially expressed between probable multiple sclerosis (MS) subjects that further converted to the definite diagnosis of MS and healthy controls. More particularly, but not exclusively, such differentially expressed markers can be used to determine the probability of a subject diagnosed with probable MS to develop a definite diagnosis of MS. In addition, the present invention, in some embodiments thereof, can be used to select a treatment regimen for subjects diagnosed with probable MS based on the expression pattern of such genetic markers. 
     Before explaining at least one embodiment of the invention in detail, it is to be understood that the invention is not limited in its application to the details set forth in the following description or exemplified by the Examples. The invention is capable of other embodiments or of being practiced or carried out in various ways. Also, it is to be understood that the phraseology and terminology employed herein is for the purpose of description and should not be regarded as limiting. 
     While reducing the present invention to practice, the present inventors have uncovered genetic markers which are predictive to the definite diagnosis of MS in subjects diagnosed with probable MS, i.e., following the first neurological attack. 
     As is shown in  FIGS. 1   a - b , Table 1 and is described in Example 1 of the Examples section which follows, the present inventors have uncovered 554 genes which are differentially expressed in PBMC between subjects with probable MS and healthy controls. Following a 2-years follow up, the subjects diagnosed with probable MS were divided to those who eventually developed a diagnosis of definite MS (convertors to definite MS) or sustained the diagnosis of probable MS (non-convertors to definite MS). Analysis of the gene expression pattern of probable MS subjects which further converted to definite MS revealed 1517 genes which are differentially expressed as compared to healthy controls (Table 2,  FIGS. 2   a - b  and Example 2 of the Examples section which follows). In addition, analysis of the gene expression pattern of probable MS subjects which did not convert to definite MS within a period of 2 years revealed 503 genes which are differentially expressed as compared to healthy controls (Table 3, Example 2 of the Examples section which follows). Moreover, comparison of the gene expression pattern of subjects with a definite diagnosis of MS to that of healthy controls revealed 722 genes which are differentially expressed (Table 4, Example 2 of the Examples section which follows). Furthermore, comparison of the differentiating genes between probable MS subjects which further converted to definite MS to that of subjects with the definite diagnosis of MS revealed that the expression pattern of 58 genes is common between the two groups of samples (Table 5, Example 3 of the Examples section which follows). In addition, application of the SVM software based on RBF kernel on a randomly assigned training set of 80% of the 40 probable MS patients revealed optimal sets of genes and their prediction power (average error in test set) of the probability of a subject diagnosed with probable MS to develop the definite diagnosis of MS (Table 6, Example 3 of the Examples section which follows). These results suggest that the expression pattern of each of the 58 genes and/or a combination of several or all of the 58 genes has a predictive value in determining the probability of a subject diagnosed with probable MS to develop the definite diagnosis of MS. 
     Thus, according to one aspect of the present invention there is provided a method of determining a probability of a subject diagnosed with probable multiple sclerosis to develop definite multiple sclerosis. The method is effected by determining in a cell of the subject a level of expression of at least one polynucleotide sequence selected from the group consisting of SEQ ID NOs:4, 16, 5, 56, 20, 3, 1, 10, 57, 24, 14, 49, 13, 37, 6, 47, 50, 21, 46, 8, 26, 2, 15, 51, 44, 19, 17, 25, 33, 48, 36, 34, 12, 29, 23, 11, 45, 53, 41, 40, 31, 58, 27, 43, 35, 30, 52, 55, 7, 9, 42, 28, 54, 32, 22, 18, 38, and 39, wherein an alteration above a predetermined threshold in the level of expression of the at least one polynucleotide sequence in the cell of the subject relative to a level of expression of the at least one polynucleotide sequence in a reference cell is indicative of the probability of the subject diagnosed with probable multiple sclerosis to develop definite multiple sclerosis. 
     As used herein, the phrase “a subject diagnosed with probable multiple sclerosis” refers to a mammal, preferably a human being, who is diagnosed with probable multiple sclerosis, e.g., a subject who experienced one neurological attack affecting the CNS and accompanied by demyelinating lesions on brain magnetic resonance imaging (MRI). The neurological attack can involve acute or sub-acute neurological symptomatology (attack) manifested by various clinical presentations like unilateral loss of vision, vertigo, ataxia, incoordination, gait difficulties, sensory impairment characterized by paresthesia, dysesthesia, sensory loss, urinary disturbances until incontinence, diplopia, dysarthria, various degrees of motor weakness until paralysis, cognitive decline either as a monosymptomatic or in combination. The symptoms usually remain for several days to few weeks, and then partially or completely resolve. 
     The diagnosis of probable MS can also include laboratory tests involving evaluation of IgG synthesis and oligoclonal bands (immunoglobulins found in 85-95% of subjects diagnosed with definite MS) in the cerebrospinal fluid (CSF, obtained by e.g., lumbar puncture) which provide evidence of chronic inflammation of the central nervous system. Combined with MRI of the brain and spinal cord and clinical data, the presence of oligoclonal bands can help make a definite diagnosis of MS. 
     As used herein, the phrase “determining a probability” refers to the likelihood of a subject diagnosed with probable MS to develop the definite diagnosis of MS within a certain time period. According to an embodiment of the invention, such probability can be high, e.g., more than 51%, at least 60%, at least 70%, at least 80%, at least 85%, at least 87%, at least 90%, at least 95%, at least 99%, e.g., 100%, that a subject diagnosed with probable MS will develop the definite diagnosis of MS. It will be appreciated that the time period during which the subject diagnosed with probable MS will convert to the definite diagnosis of MS can be within 1 year since onset of probable MS, within 2-3 years, within 3-5 years, or more. 
     As used herein the phrase “develop definite multiple sclerosis” refers to a subject who is diagnosed with probable MS and which experiences at least a second neurological attack affecting the CNS and accompanied by demyelinating lesions on brain magnetic resonance imaging (MRI), wherein the neurological attacks are associated with the appearance of new neurological symptoms and signs or the worsening of existing neurological symptoms and signs. It will be appreciated that the disease course of patients diagnosed with definite MS can be a relapsing-remitting multiple sclerosis (RRMS) (occurring in 85% of the patients), a primary progressive multiple sclerosis (occurring in 15% of the patients) or a secondary progressive multiple sclerosis (occurring in 40% of the RRMS patients; see  FIG. 4 ). 
     As mentioned, the method according to this aspect of the present invention is effected by determining in a cell of the subject a level of expression of at least one polynucleotide sequence selected from the group consisting of SEQ ID NOs:4, 16, 5, 56, 20, 3, 1, 10, 57, 24, 14, 49, 13, 37, 6, 47, 50, 21, 46, 8, 26, 2, 15, 51, 44, 19, 17, 25, 33, 48, 36, 34, 12, 29, 23, 11, 45, 53, 41, 40, 31, 58, 27, 43, 35, 30, 52, 55, 7, 9, 42, 28, 54, 32, 22, 18, 38, and 39. 
     According to an embodiment of the invention, the method is effected by determining in a cell of the subject a level of expression of at least two, at least three, at least four, at least five, at least six, at least seven, at least eight, at least nine, at least 10 polynucleotide sequences, at least 20, at least 30, at least 40, at least 50 polynucleotide sequences, e.g., 58 polynucleotide sequences selected from the group consisting of SEQ ID NOs:4, 16, 5, 56, 20, 3, 1, 10, 57, 24, 14, 49, 13, 37, 6, 47, 50, 21, 46, 8, 26, 2, 15, 51, 44, 19, 17, 25, 33, 48, 36, 34, 12, 29, 23, 11, 45, 53, 41, 40, 31, 58, 27, 43, 35, 30, 52, 55, 7, 9, 42, 28, 54, 32, 22, 18, 38, and 39, wherein an alteration above a predetermined threshold in the level of expression of each of the polynucleotide sequences in the cell of the subject relative to a level of expression of the same polynucleotide sequences in a reference cell is indicative of the probability of the subject diagnosed with probable multiple sclerosis to develop definite multiple sclerosis. 
     As mentioned above, shown in Table 6 and described in Example 3 of the Examples section which follows, the prediction power of the selected polynucleotides set forth by SEQ ID NOs:1-58 in determining the probability of a subject diagnosed with probable MS to develop definite MS within 2 years was computed using the SVM based on RBF kernel when applied on a set of 40 probable MS subjects, randomly divided to 80% as training set and 20% as test set. The polynucleotide sequence exhibiting the best prediction power as a single gene, which can be used to determine the probability of a subject diagnosed with probable MS to develop definite multiple sclerosis is set forth in SEQ ID NO:4 (average error: 0.216; prediction accuracy of 78.4%). 
     As is further shown in Table 6 (Example 3) several groups of genes can predict the probability of a subject diagnosed with probable MS to develop a definite multiple sclerosis within 2 years with about 87% accuracy (average error of about 0.13). 
     According to an embodiment of the invention, the polynucleotide sequences which expression level are determined in the cell of the subject diagnosed with probable MS are those depicted in any of the following groups of row numbers of Table 6 in Example 3 of the Examples section which follows: rows 1-33; rows 1-34; rows 1-35; rows 1-40; rows 1-44; and rows 1-45. 
     As is further shown in Table 6 (Example 3) several groups of genes can predict the probability of a subject diagnosed with probable MS to develop a definite multiple sclerosis within 2 years with about 84-86% accuracy (average error of about 0.14-0.16). 
     According to an embodiment of the invention, the polynucleotide sequences which expression level are determined in the cell of the subject diagnosed with probable MS are those depicted in any of the following groups of row numbers of Table 6 in Example 3 of the Examples section which follows: rows 1-6; rows 1-14; rows 1-15; rows 1-16; rows 1-17; rows 1-18; rows 1-19; rows 1-29; rows 1-31; rows 1-32; rows 1-36; rows 1-37; rows 1-38; rows 1-39; rows 1-40; rows 1-41; rows 1-42; rows 1-43; rows 1-46; rows 1-47; rows 1-48; rows 1-49; rows 1-50; and rows 1-52. 
     As is further shown in Table 6 (Example 3) several groups of genes can predict the probability of a subject diagnosed with probable MS to develop a definite multiple sclerosis diagnosis with about 80-83% accuracy (average error of about 0.17-0.20). 
     According to an embodiment of the invention, the polynucleotide sequences which expression level are determined in the cell of the subject diagnosed with probable MS are those depicted in any of the following groups of row numbers of Table 6 in Example 3 of the Examples section which follows: rows 1-7; rows 1-8; rows 1-9; rows 1-10; rows 1-12; rows 1-13; rows 1-20; rows 1-21; rows 1-22; rows 1-23; rows 1-24; rows 1-25; rows 1-26; rows 1-27; rows 1-28; rows 1-30; rows 1-51; rows 1-53; rows 1-54; rows 1-55; rows 1-56; rows 1-57; and rows 1-58. 
     As is further shown in Table 6 (Example 3) several groups of genes can predict the probability of a subject diagnosed with probable MS to develop a definite multiple sclerosis diagnosis with about 75-79% accuracy (average error of about 0.21-0.25). 
     According to an embodiment of the invention, the polynucleotide sequences which expression level are determined in the cell of the subject diagnosed with probable MS are those depicted in any of the following groups of row numbers of Table 6 in Example 3 of the Examples section which follows: rows 1-2; rows 1-3; rows 1-4; rows 1-5; and rows 1-11. 
     As used herein, the phrase “level of expression” refers to the degree of gene expression and/or gene product activity in a specific cell. For example, up-regulation or down-regulation of various genes can affect the level of the gene product (i.e., RNA and/or protein) in a specific cell. 
     As used herein the phrase “a cell of the subject” refers to any cell content and/or cell secreted content which contains RNA and/or proteins of the subject. 
     Examples include a blood cell, a bone marrow cell, a cell obtained from any tissue biopsy (e.g., CSF, brain biopsy), body fluids such as plasma, serum, saliva, spinal fluid, lymph fluid, the external sections of the skin, respiratory, intestinal, and genitourinary tracts, tears, saliva, sputum and milk. According to an embodiment of the invention, the cell is a blood cell (e.g., white blood cells, macrophages, B- and T-lymphocytes, monocytes, neutrophiles, eosinophiles, and basophiles) which can be obtained using a syringe needle from a vein of the subject. It will be appreciated that PBMC is the most accessible tissue and could be useful as a minimally invasive approach for gene expression differential diagnosis. It should be noted that a “cell of the subject” may also optionally comprise a cell that has not been physically removed from the subject (e.g., in vivo detection). 
     According to an embodiment of the invention, the white blood cell comprises peripheral blood mononuclear cells (PBMC). The phrase, “peripheral blood mononuclear cells (PBMCs)” as used herein, refers to a mixture of monocytes and lymphocytes. Several methods for isolating white blood cells are known in the art. For example, PBMCs can be isolated from whole blood samples using density gradient centrifugation procedures. Typically, anticoagulated whole blood is layered over the separating medium. At the end of the centrifugation step, the following layers are visually observed from top to bottom: plasma/platelets, PBMCs, separating medium and erythrocytes/granulocytes. The PBMC layer is then removed and washed to remove contaminants (e.g., red blood cells) prior to determining the expression level of the polynucleotide(s) therein. 
     It will be appreciated that the cell of the subject can be obtained at any time, e.g., immediately after an attack or at any time during remission. 
     According to preferred embodiments of the present invention, detecting the level of expression of the polynucleotide sequences of the present invention is effected using RNA or protein molecules which are extracted from the cell of the subject. 
     Methods of extracting RNA or protein molecules from cells of a subject are well known in the art. 
     Once obtained, the RNA or protein molecules can be characterized for the expression and/or activity level of various RNA and/or protein molecules using methods known in the arts. 
     Non-limiting examples of methods of detecting RNA molecules in a cell sample include Northern blot analysis, RT-PCR, RNA in situ hybridization (using e.g., DNA or RNA probes to hybridize RNA molecules present in the cells or tissue sections), in situ RT-PCR (e.g., as described in Nuovo G J, et al. Am J Surg Pathol. 1993, 17: 683-90; Komminoth P, et al. Pathol Res Pract. 1994, 190: 1017-25), and oligonucleotide microarray (e.g., by hybridization of polynucleotide sequences derived from a sample to oligonucleotides attached to a solid surface [e.g., a glass wafer) with addressable location, such as Affymetrix microarray (Affymetrix®, Santa Clara, Calif.)]. 
     Non-limiting examples of methods of detecting the level and/or activity of specific protein molecules in a cell sample include Enzyme linked immunosorbent assay (ELISA), Western blot analysis, radio-immunoassay (RIA), Fluorescence activated cell sorting (FACS), immunohistochemical analysis, in situ activity assay (using e.g., a chromogenic substrate applied on the cells containing an active enzyme), in vitro activity assays (in which the activity of a particular enzyme is measured in a protein mixture extracted from the cells). 
     For example, in case the detection of the expression level of a secreted protein is desired, ELISA assay may be performed on a sample of fluid obtained from the subject (e.g., serum), which contains cell-secreted content. 
     As used herein the phrase “reference cell” refers to any cell as described hereinabove of an unaffected subject (i.e., a subject devoid of any neurological attack resembling MS or probable MS) such as a healthy subject, which can be an age and/or gender-matched unaffected subject (e.g., a healthy subject from the same age and/or gender as of the subject diagnosed with probable MS). Such a reference cell can be a blood cell, a bone marrow cell, a cell obtained from any tissue biopsy (e.g., CSF), body fluids such as plasma, serum, saliva, spinal fluid, lymph fluid, the external sections of the skin, respiratory, intestinal, and genitourinary tracts, tears, saliva, sputum and milk. It will be appreciated that the level of expression of the above referenced polynucleotides/polypeptides may be obtained from scientific literature. 
     Since as is shown in Table 5 and is described in Example 2 of the Examples section which follows, 27 polynucleotide sequences displayed elevated expression in the subjects diagnosed with probable MS which further developed the definite diagnosis of MS relative to healthy subjects, in order to determine the probability of a subject diagnosed with probable MS to develop definite MS, the level of expression of at least one polynucleotide sequence selected from the group consisting of SEQ ID NOs:32-58 is determined and compared to the level of expression of the same polynucleotide sequences in a reference cell derived from an unaffected subject, wherein an upregulation (increase) in the expression level of the at least one polynucleotide sequence above a predetermined threshold relative to the reference cell is indicative of a high probability (e.g., higher than about 75%, about 80%, about 85%, about 87%) of the subject diagnosed with probable MS to develop definite MS (e.g., to convert to definite MS within a period of about 2 years). On the other hand, downregulation or no significant change in the level of expression, of the same at least one polynucleotide sequence relative to the reference cell is indicative of low probability (e.g., less than about 75%, e.g., less than 50%, e.g., less than 30%) of the subject diagnosed with probable MS to develop definite MS (e.g., to convert to definite MS within a period of about 2 years). It will be appreciated that such a subject can eventually develop definite MS following a longer period of time, e.g. more than 2 years, e.g., 10-20 years. 
     Additionally or alternatively, since as is further shown in Table 2 and is described in Example 2 of the Examples section which follows, the level of expression of 31 polynucleotide sequences was downregulated in subjects diagnosed with probable MS relative to the healthy control subjects, in order to determine the probability of a subject diagnosed with probable MS to develop definite MS, the level of expression of at least one polynucleotide sequence selected from the group consisting of SEQ ID NOs:1-31 is determined and compared to the level of expression of the same polynucleotide sequences in a reference cell derived from an unaffected subject, wherein downregulation (decrease) in the expression level of the at least one polynucleotide sequence above a predetermined threshold relative to the reference cell is indicative of high probability (e.g., higher than about 75%, about 80%, about 85%, about 87%) of the subject diagnosed with probable MS to develop definite MS (e.g., to convert to definite MS within a period of about 2 years). On the other hand, upregulation or no significant change in the level of expression of the same at least one polynucleotide sequence relative to the reference cell is indicative of low probability (e.g., lower than 75%, e.g., less than 50%, e.g., less than 30%) of the subject diagnosed with probable MS to develop definite MS (e.g., to convert to definite MS within a period of about 2 years). It will be appreciated that such a subject can eventually develop definite MS following a longer period of time, e.g., more than 2 years. 
     As used herein the phrase “an alteration above a predetermined threshold” refers to the increase or decrease (i.e., degree of upregulation or downregulation, respectively) which is higher than a predetermined threshold such as at least twice, at least three times, at least four times, at least five times, at least six times, at least seven times, at least eight times, at least nine times, at least 10 times, at least 20 times, at least 50 times, at least 100 times, at least 500 times relative to the reference cell. 
     For example, as is shown in Table 5, while the level of expression of the polynucleotide sequences set forth by SEQ ID NOs:1-16, is at least twice lower in subjects diagnosed with probable MS which further developed definite MS as compared to unaffected subjects, the level of expression of the polynucleotide sequences set forth by SEQ ID NOs:17-26, the polynucleotide sequences set forth by SEQ ID NOs:27-29, or the polynucleotides set forth by SEQ ID NOs:30-31 is at least 5, 10, or 50 times, respectively, lower in cells of subjects diagnosed with probable MS which further developed definite MS as compared to unaffected, healthy subjects. 
     In addition, as is further shown in Table 2, while the level of expression of the polynucleotide sequences set forth by SEQ ID NOs:32-46, is at least twice higher in subjects diagnosed with probable MS which further developed definite MS as compared to unaffected, healthy subjects, the level of expression of the polynucleotide sequences set forth by SEQ ID NOs:47-52, the polynucleotides set forth by SEQ ID NOs:53-56, or the polynucleotide set forth by SEQ ID NOs:57-58 is at least 5, 10, or 50 times, respectively, higher in cells of subjects diagnosed with probable MS which further developed definite MS as compared to unaffected, healthy subjects. 
     It will be appreciated that higher fold change in the expression level of the at least one polynucleotide in the cell of the subject relative the reference cell, and/or alteration in the level of expression of the polynucleotides which exhibit high fold change in Table 5 of Example 2 (e.g., SEQ ID NOs:17-26 and/or 47-52, SEQ ID NOs:27-29 and/or 53-56, 30-31 and/or 57-58), and/or alteration above the predetermined threshold in a significant number of polynucleotides from the polynucleotides set forth by SEQ ID NOs:4, 16, 5, 56, 20, 3, 1, 10, 57, 24, 14, 49, 13, 37, 6, 47, 50, 21, 46, 8, 26, 2, 15, 51, 44, 19, 17, 25, 33, 48, 36, 34, 12, 29, 23, 11, 45, 53, 41, 40, 31, 58, 27, 43, 35, 30, 52, 55, 7, 9, 42, 28, 54, 32, 22, 18, 38, and 39 (e.g., at least 30, at least 40, at least 45, at least 50, or 58) will indicate high probability that the subject diagnosed with probable MS will develop definite MS within a short period of time (during 2 years). 
     Thus, the method of determining the probability of a subject diagnosed with probable MS to develop definite MS according to the invention enables the classification of probable MS patients to those that will develop definite MS within a predetermined time (e.g., about 2 years, fast convertors) and to those who will sustain the diagnosis of probable MS and will either not convert to definite MS or will convert to definite MS following an extended period of time (e.g., more than 2 years, e.g., at least 10 years). 
     Thus, the teachings of the present invention can be used to improve the diagnosis of definite MS following the first neurological attack, without needing to rely on the appearance of the second neurological attack. 
     It will be appreciated that determining the probability of a subject diagnosed with probable MS to develop definite MS can be used to select the treatment regimen of the subject and thereby to treat the subject diagnosed with probable MS. 
     Thus, according to an aspect of some embodiments of the present invention there is provided a method of treating a subject diagnosed with probable multiple sclerosis. The method is effected by: (a) determining in a cell of the subject a level of expression of at least one polynucleotide sequence selected from the group consisting of SEQ ID NOs:4, 16, 5, 56, 20, 3, 1, 10, 57, 24, 14, 49, 13, 37, 6, 47, 50, 21, 46, 8, 26, 2, 15, 51, 44, 19, 17, 25, 33, 48, 36, 34, 12, 29, 23, 11, 45, 53, 11, 40, 31, 58, 27, 43, 35, 30, 52, 55, 7, 9, 42, 28, 54, 32, 22, 18, 38, and 39, wherein an alteration above a predetermined threshold in the level of expression of the at least one polynucleotide sequence in the cell of the subject relative to a level of expression of the at least one polynucleotide sequence in a reference cell is indicative of a probability of the subject diagnosed with probable multiple sclerosis to develop definite multiple sclerosis, and (b) selecting a treatment regimen based on the probability, thereby treating the subject diagnosed with probable multiple sclerosis. 
     As used herein the phrase “treating” refers to inhibiting or arresting the development of a pathology [multiple sclerosis, e.g., RRMS or progressive (e.g., primary or secondary) MS] and/or causing the reduction, remission, or regression of a pathology and/or optimally curing the pathology. Those of skill in the art will understand that various methodologies and assays can be used to assess the development of a pathology, and similarly, various methodologies and assays may be used to assess the reduction, remission or regression of the pathology. 
     According to an embodiment of the invention, when the probability as determined according to the method of the invention of the subject diagnosed with probable MS to develop definite MS is high [e.g., at least 89.9% that the subject will develop definite MS within 2 years], the treatment regimen selected for treating such a subject comprises preventive medications which will prevent the reaction leading to neurological disability. It will be appreciated that the currently available medications for treating definite MS are not allowed for treating subjects diagnosed with probable MS. Thus, teachings of the invention can be used to prevent the neurological deterioration of subjects diagnosed with probable MS. 
     Thus, by determining the probability of the subject diagnosed with probable MS to develop definite MS, the subject can be treated early, prior to experiencing the second neurological attack, with suitable therapeutics that can prevent deterioration of clinical symptoms and can increase the chances of achieving cure and remission of symptoms in the affected subjects. 
     It will be appreciated that classification of subjects diagnosed with probable MS to those that will convert fast to definite MS and to those that will sustain the diagnosis of probable MS can be also used in order to assess the efficacy of a treatment regimen on probable MS patients which are likely to develop definite MS. Thus, by treating subjects with probable MS and high probability to develop definite MS (as determined by the method of the invention) with candidate preventive and/or therapeutic drugs and monitoring the subjects&#39; health in terms of MS progression (e.g., EDSS evaluation and number of relapses), the efficacy of the drugs can be assessed. 
     The teachings of the invention are of utmost importance and have relevant medical, economical and social aspects. While the MS disease prevalence in USA is at the range of 250.000 to 350.000 cases, the annual cost of MS in USA is anticipated to be 34,000 $ per patient, leading to 2.2 million $ total lifetime cost per patient or 6.8 billion $ yearly, in a conservative estimate of the national annual cost. The possibility to early identify the patients which will develop definite MS among the patients with the diagnosis of probable MS is of utmost importance, as it would be possible to start preventive treatment early and delay accumulation of irreversible neurological disability, inhibition/suppression of disease progression as well as reduce annual cost of disease. 
     It will be appreciated that the reagents utilized by any of the methods of the present invention which are described hereinabove can form a part of a diagnostic kit/article of manufacture. 
     The kit of the invention comprises at least one and no more than 500 isolated nucleic acid sequences, e.g., at least 2 and no more than 500 isolated nucleic acid sequences, e.g., at least 4 and no more than 400 isolated nucleic acid sequences, e.g., at least 6 and no more than 300 isolated nucleic acid sequences, e.g., at least 8 and no more than 200 isolated nucleic acid sequences, e.g., at least 2 and no more than 100 isolated nucleic acid sequences, e.g., at least 2 and no more than 58 isolated nucleic acid sequences, wherein each of the at least one and no more than 500 isolated nucleic acid sequences is capable of specifically recognizing at least one specific polynucleotide sequence selected from the group consisting of SEQ ID NOs:4, 16, 5, 56, 20, 3, 1, 10, 57, 24, 14, 49, 13, 37, 6, 47, 50, 21, 46, 8, 26, 2, 15, 51, 44, 19, 17, 25, 33, 48, 36, 34, 12, 29, 23, 11, 45, 53, 41, 40, 31, 58, 27, 43, 35, 30, 52, 55, 7, 9, 42, 28, 54, 32, 22, 18, 38, and 39. 
     The isolated nucleic acid sequences included in the kit of the present invention can be single-stranded or double-stranded, naturally occurring or synthetic nucleic acid sequences such as oligonucleotides, RNA molecules, genomic DNA molecules, cDNA molecules and/or cRNA molecules. The isolated nucleic acid sequences of the kit can be composed of naturally occurring bases, sugars, and covalent internucleoside linkages (e.g., backbone), as well as non-naturally occurring portions, which function similarly to respective naturally occurring portions. 
     Synthesis of the isolated nucleic acid sequences of the kit can be performed using enzymatic synthesis or solid-phase synthesis. Equipment and reagents for executing solid-phase synthesis are commercially available from, for example, Applied Biosystems. Any other means for such synthesis may also be employed; the actual synthesis of the oligonucleotides is well within the capabilities of one skilled in the art and can be accomplished via established methodologies as detailed in, for example: Sambrook, J. and Russell, D. W. (2001), “Molecular Cloning: A Laboratory Manual”; Ausubel, R. M. et al., eds. (1994, 1989), “Current Protocols in Molecular Biology,” Volumes I-III, John Wiley &amp; Sons, Baltimore, Md.; Perbal, B. (1988), “A Practical Guide to Molecular Cloning,” John Wiley &amp; Sons, New York; and Gait, M. J., ed. (1984), “Oligonucleotide Synthesis”; utilizing solid-phase chemistry, e.g. cyanoethyl phosphoramidite followed by deprotection, desalting, and purification by, for example, an automated trityl-on method or HPLC. 
     According to an embodiment of the invention, each of the isolated nucleic acid sequences included in the kit of present invention comprises at least 10 and no more than 50 nucleic acids, e.g., at least 15 and no more than 45, e.g., between 15-40, e.g., between 20-35, e.g., between 20-30, e.g., between 20-25 nucleic acids. 
     According to an embodiment of the invention the kit includes at least one reagent as described hereinabove which is suitable for recognizing the at least one specific polynucleotide sequence selected from the group consisting of SEQ ID NOs:4, 16, 5, 56, 20, 3, 1, 10, 57, 24, 14, 49, 13, 37, 6, 47, 50, 21, 46, 8, 26, 2, 15, 51, 44, 19, 17, 25, 33, 48, 36, 34, 12, 29, 23, 11, 45, 53, 41, 40, 31, 58, 27, 43, 35, 30, 52, 55, 7, 9, 42, 28, 54, 32, 22, 18, 38, and 39. Examples include reagents suitable for hybridization or annealing of a specific polynucleotide of the kit to a specific target polynucleotide sequence (e.g., RNA transcript derived from the cell of the subject or a cDNA derived therefrom) such as formamide, sodium chloride, and sodium citrate), reagents which can be used to labeled polynucleotides (e.g., radiolabeled nucleotides, biotinylated nucleotides, digoxigenin-conjugated nucleotides, fluorescent-conjugated nucleotides) as well as reagents suitable for detecting the labeled polynucleotides (e.g., antibodies conjugated to fluorescent dyes, antibodies conjugated to enzymes, radiolabeled antibodies and the like). 
     Additionally or alternatively, the kit of the present invention comprises at least one reagent suitable for detecting the expression level and/or activity of at least one polypeptide encoded by at least one polynucleotides selected from the group consisting of SEQ ID NOs:4, 16, 5, 56, 20, 3, 1, 10, 57, 24, 14, 49, 13, 37, 6, 47, 50, 21, 46, 8, 26, 2, 15, 51, 44, 19, 17, 25, 33, 48, 36, 34, 12, 29, 23, 11, 45, 53, 41, 40, 31, 58, 27, 43, 35, 30, 52, 55, 7, 9, 42, 28, 54, 32, 22, 18, 38, and 39. Such a reagent can be, for example, an antibody capable of specifically binding to at least one epitope of the polypeptide. Additionally or alternatively, the reagent included in the kit can be a specific substrate capable of binding to an active site of the polypeptide. In addition, the kit may also include reagents such as fluorescent conjugates, secondary antibodies and the like which are suitable for detecting the binding of a specific antibody and/or a specific substrate to the polypeptide. 
     According to an embodiment of the invention the kit includes a reference cell which comprises a cell of an unaffected subject as described hereinabove. 
     According to an embodiment of the invention, the kit of the invention includes packaging material packaging the at least one reagent and a notification in or on the packaging material. Such a notification identifies the kit for use in determining the probability of a subject diagnosed with probable MS to develop definite MS and selecting a treatment regimen of a subject and thereby treating the subject diagnosed with probable MS. The kit may also include instructions for use in determining the probability of a subject diagnosed with probable MS to develop definite MS and selecting a treatment regimen of a subject and thereby treating the subject diagnosed with probable MS. The kit may also include appropriate buffers and preservatives for improving the shelf-life of the kit. 
     It will be appreciated that the isolated nucleic acid sequences described hereinabove (e.g., oligonucleotides) can form a part of a probeset. The probeset comprises a plurality of oligonucleotides and no more than 500 oligonucleotides wherein each of the plurality of oligonucleotides is capable of specifically recognizing at least one polynucleotide sequence selected from the group consisting of SEQ ID NOs:4, 16, 5, 56, 20, 3, 1, 10, 57, 24, 14, 49, 13, 37, 6, 47, 50, 21, 46, 8, 26, 2, 15, 51, 44, 19, 17, 25, 33, 48, 36, 34, 12, 29, 23, 11, 45, 53, 41, 40, 31, 58, 27, 43, 35, 30, 52, 55, 7, 9, 42, 28, 54, 32, 22, 18, 38, and 39. 
     It will be appreciated that the isolated nucleic acid sequences included in the kit or the probeset of the present invention can be bound to a solid support e.g., a glass wafer in a specific order, i.e., in the form of a microarray. Alternatively, isolated nucleic acid sequences can be synthesized directly on the solid support using well known prior art approaches (Seo T S, et al., 2004, Proc. Natl. Acad. Sci. USA, 101: 5488-93.). In any case, the isolated nucleic acid sequences are attached to the support in a location specific manner such that each specific isolated nucleic acid sequence has a specific address on the support (i.e., an addressable location) which denotes the identity (i.e., the sequence) of that specific isolated nucleic acid sequence. 
     According to preferred embodiments of the present invention the microarray comprises no more than 500 isolated nucleic acid sequences, wherein each of the isolated nucleic acid sequences is capable of specifically recognizing at least one specific polynucleotide sequence selected from the group consisting of SEQ ID NOs: 4, 16, 5, 56, 20, 3, 1, 10, 57, 24, 14, 49, 13, 37, 6, 47, 50, 21, 46, 8, 26, 2, 15, 51, 44, 19, 17, 25, 33, 48, 36, 34, 12, 29, 23, 11, 45, 53, 41, 40, 31, 58, 27, 43, 35, 30, 52, 55, 7, 9, 42, 28, 54, 32, 22, 18, 38, and 39. 
     As used herein the term “about” refers to ±10%. 
     Additional objects, advantages, and novel features of the present invention will become apparent to one ordinarily skilled in the art upon examination of the following examples, which are not intended to be limiting. Additionally, each of the various embodiments and aspects of the present invention as delineated hereinabove and as claimed in the claims section below finds experimental support in the following examples. 
     EXAMPLES 
     Reference is now made to the following examples, which together with the above descriptions; illustrate the invention in a non-limiting fashion. 
     Generally, the nomenclature used herein and the laboratory procedures utilized in the present invention include molecular, biochemical, microbiological and recombinant DNA techniques. Such techniques are thoroughly explained in the literature. See, for example, “Molecular Cloning: A laboratory Manual” Sambrook et al., (1989); “Current Protocols in Molecular Biology” Volumes I-III Ausubel, R. M., ed. (1994); Ausubel et al., “Current Protocols in Molecular Biology”, John Wiley and Sons, Baltimore, Md. (1989); Perbal, “A Practical Guide to Molecular Cloning”, John Wiley &amp; Sons, New York (1988); Watson et al., “Recombinant DNA”, Scientific American Books, New York; Birren et al. (eds) “Genome Analysis: A Laboratory Manual Series”, Vols. 1-4, Cold Spring Harbor Laboratory Press, New York (1998); methodologies as set forth in U.S. Pat. Nos. 4,666,828; 4,683,202; 4,801,531; 5,192,659 and 5,272,057; “Cell Biology: A Laboratory Handbook”, Volumes I-III Cellis, J. E., ed. (1994); “Current Protocols in Immunology” Volumes I-III Coligan J. E., ed. (1994); Stites et al. (eds), “Basic and Clinical Immunology” (8th Edition), Appleton &amp; Lange, Norwalk, Conn. (1994); Mishell and Shiigi (eds), “Selected Methods in Cellular Immunology”, W. H. Freeman and Co., New York (1980); available immunoassays are extensively described in the patent and scientific literature, see, for example, U.S. Pat. Nos. 3,791,932; 3,839,153; 3,850,752; 3,850,578; 3,853,987; 3,867,517; 3,879,262; 3,901,654; 3,935,074; 3,984,533; 3,996,345; 4,034,074; 4,098,876; 4,879,219; 5,011,771 and 5,281,521; “Oligonucleotide Synthesis” Gait, M. J., ed. (1984); “Nucleic Acid Hybridization” Hames, B. D., and Higgins S. J., eds. (1985); “Transcription and Translation” Hames, B. D., and Higgins S. J., Eds. (1984); “Animal Cell Culture” Freshney, R. I., ed. (1986); “Immobilized Cells and Enzymes” IRL Press, (1986); “A Practical Guide to Molecular Cloning” Perbal, B., (1984) and “Methods in Enzymology” Vol. 1-317, Academic Press; “PCR Protocols: A Guide To Methods And Applications”, Academic Press, San Diego, Calif. (1990); Marshak et al., “Strategies for Protein Purification and Characterization—A Laboratory Course Manual” CSHL Press (1996); all of which are incorporated by reference as if fully set forth herein. Other general references are provided throughout this document. The procedures therein are believed to be well known in the art and are provided for the convenience of the reader. All the information contained therein is incorporated herein by reference. 
     General Materials and Experimental Methods 
     Study design and study subjects—40 patients with probable MS of up to 3 months duration according to Poser&#39;s criteria (1983, CPMS C3: 1 attack, at least 1 clinical manifestation in addition to positive brain MRI signifying paraclinical evidence) were included in the study. Positive brain MM was defined according to Fazekas&#39;s criteria (1999) by at least 4 focal lesions involving the white matter or 3 lesions if one is periventricular; ≧3 mm in diameter, each. For the evaluation of probable MS related transcription fingerprints the large-scale gene expression profile of patients was compared with the data of 10 sex- and age-matched healthy subjects. Verification of probable PBMC gene expression signature was performed on Signed written informed consent was obtained from all participants. 
     Clinical neurological assessment—Neurological examination and assessment of disability was performed by the Expanded Disability Status Scale (EDSS) score (17) performed at screening, baseline visit, and at 24, 36 and 48 weeks of follow-up visits. The occurrence of a second acute attack, the time to second attack (progression to definite MS) and the change in neurological disability assessed by the EDSS were recorded in each patient. Second attack was defined as the onset of new neurological symptoms or worsening of previous ones occurring at least 30 days after the first attack, lasting for at least 48 hours and involving an objective increase by at least 0.5 point in the EDSS. 
     MRI examination—Brain MRI was performed using a 3.0 Tesla Imager (GE): Axial dual spin-echo (PD and T2 sequences) and T1-weighted images before and after intravenous administration of Gd-DTPA. Brain lesion load was quantified using the MSAnalyze software (18). This automated technique is based on several mathematical algorithms (e.g., Bayesian classification, near-neighborhood) leading to brain tissue segmentation enabling precise 3-dimensional lesions&#39; identification and volumetric quantification. 
     PBMC preparation—Blood sample (20 ml) was drawn from all study subjects. No corticosteroid treatment was given for at least 4 weeks prior to blood drawing. PBMC were separated on Ficoll hypaque, washed with PBS and the pellet frozen in liquid nitrogen. 
     RNA extraction—Frozen PBMC were homogenized in ice cold trizol and total RNA extracted and used as a template for double stranded cDNA synthesis (Affymetrix, Santa Clara, Calif.). RNA quantity was determined by optical density measurements at 260 nm and its quality by running the RNA on a formamide-formaldehyde denaturing gel. 
     Preparation of labeled cRNA—Double stranded cDNA was performed using a cDNA synthesis kit (Life Technologies Superscript cDNA Synthesis System) with an oligo (dT) primer containing a T7 RNA polymerase promoter site added to the 3′. The cDNA was used as a template for in vitro transcription with biotin labeled nucleotides (Enzo Diagnostics). Labeled cRNA was used for hybridization. 
     Hybridization of microarrays—Each Genechip array (U133A) was hybridized with 10 μg/200 μl hybridization mix, stained with streptavidin phycoerythrin (Molecular Probes), hybridized with biotin labeled anti-streptavidin phycoerythrin antibody, re-stained with streptavidin phycoerythrin and scanned (Hewlett Packard, GeneArray-™ scanner G2500A). 
     Data analysis—Data were analyzed using ScoreGene software. To correct for multiple testing the False Discovery Rate (FDR) method and the stringent Bonferroni correction were applied. Overabundance analysis was performed to examine the observed results in comparison to expected results. To assess and validate the predictive power of the gene expression signature, the following methods were applied: Leave-One-Out-Cross-Validation (LOOCV) (21; Ben-Dor A et al., 2000) Principal Component Analysis (PCA), and Support vector machine (SVM) [(http://ro.utia.cz/fs/fs_algorithms.html), (19, 20). The study involves various comparisons between subjects of the data set. Due to the reasons of controls compatibility, the number of controls changes from one comparison to another. 
     Computation of the average error in determining which probable multiple sclerosis (MS) subjects exhibit high probability (predisposition) to develop the definite diagnosis of MS—For each of the 58 differentiating genes (SEQ ID NOs:1-58) the sample of 40 probable MS patients was randomly divided into 80% as a “training set” and 20% as a “test set”. The SVM used RBF (radial basic function) kernel to build a model based on the “training set”, which was further tested on the “test set” while saving the error rate. This procedure was repeated 25 times for each gene and the average error for each gene was calculated. Genes with the lowest average error were selected. Then, for each selected gene, the remaining genes were added one after the other, by selecting the next gene such that the average error after 25 repeats of the group of genes including the new gene has the lowest average error as compared to the addition of another gene. This process was repeated 57 times for each additional genes added to the previous group of genes. The results are shown in Table 6 and described in Example 3 hereinbelow. 
     Example 1 
     Identification of Transcripts Differentiating Between Probable MS and Healthy Subjects 
     Experimental and Statistical Results 
     Analysis of large scale gene expression pattern—Analysis of large-scale gene expression patterns of PBMC samples obtained from 28 patients with probable MS (mean±SE, age 36.0±1.9 years, EDSS 1.5±0.2) and 10 healthy matched controls was performed. Gene expression patterns of PBMC in probable MS patients were significantly different from healthy subject. Table 1, hereinbelow, depicts 554 genes that passed the 95% confidence level in all 3 statistical scores (TNoM, Info, T-test); 352 genes were over-expressed and 202 under-expressed. These genes were defined as the most informative ( FIG. 1   a ). PCA performed on the 554 most informative genes divided all samples into two separated clusters that represented probable MS patients and healthy subjects with only 2 (5%) classification errors ( FIG. 1   b ). 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Differentially expressed markers between probable 
               
               
                 multiple sclerosis subjects and healthy controls 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                 GenBank 
                   
                   
               
               
                   
                 Probeset 
                 Acc. No. 
                 Dir 
                 Gene Symbol 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 1494_f_at 
                 M33318 
                 −1 
                 CYP2A6 
               
               
                   
                 200797_s_at 
                 AI275690 
                 −1 
                 MCL1 
               
               
                   
                 200798_x_at 
                 NM_021960 
                 −1 
                 MCL1 
               
               
                   
                 201041_s_at 
                 NM_004417 
                 −1 
                 DUSP1 
               
               
                   
                 201044_x_at 
                 AA530892 
                 −1 
                 DUSP1 
               
               
                   
                 201109_s_at 
                 AV726673 
                 −1 
                 THBS1 
               
               
                   
                 201110_s_at 
                 NM_003246 
                 −1 
                 THBS1 
               
               
                   
                 201235_s_at 
                 BG339064 
                 −1 
                 BTG2 
               
               
                   
                 201236_s_at 
                 BG339064 
                 −1 
                 BTG2 
               
               
                   
                 201464_x_at 
                 BC002646 
                 −1 
                 JUN 
               
               
                   
                 201473_at 
                 NM_002229 
                 −1 
                 JUNB 
               
               
                   
                 201489_at 
                 BC005020 
                 −1 
                 PPIF 
               
               
                   
                 201490_s_at 
                 NM_005729 
                 −1 
                 PPIF 
               
               
                   
                 201502_s_at 
                 NM_020529 
                 −1 
                 NFKBIA 
               
               
                   
                 201531_at 
                 NM_003407 
                 −1 
                 ZFP36 
               
               
                   
                 201631_s_at 
                 NM_003897 
                 −1 
                 IER3 
               
               
                   
                 201647_s_at 
                 NM_005506 
                 −1 
                 SCARB2 
               
               
                   
                 201668_x_at 
                 AW163148 
                 −1 
                 MARCKS 
               
               
                   
                 201669_s_at 
                 NM_002356 
                 −1 
                 MARCKS 
               
               
                   
                 201670_s_at 
                 M68956 
                 −1 
                 MARCKS 
               
               
                   
                 201693_s_at 
                 NM_001964 
                 −1 
                 EGR1 
               
               
                   
                 201694_s_at 
                 NM_001964 
                 −1 
                 EGR1 
               
               
                   
                 202672_s_at 
                 NM_001674 
                 −1 
                 ATF3 
               
               
                   
                 204224_s_at 
                 NM_000161 
                 −1 
                 GCH1 
               
               
                   
                 201884_at 
                 NM_004363 
                 −1 
                 CEACAM5 
               
               
                   
                 202014_at 
                 NM_014330 
                 −1 
                 PPP1R15A 
               
               
                   
                 202068_s_at 
                 NM_000527 
                 −1 
                 LDLR 
               
               
                   
                 202081_at 
                 NM_004907 
                 −1 
                 IER2 
               
               
                   
                 202286_s_at 
                 J04152 
                 −1 
                 TACSTD2 
               
               
                   
                 202340_x_at 
                 NM_002135 
                 −1 
                 NR4A1 
               
               
                   
                 202570_s_at 
                 NM_014902 
                 −1 
                 DLGAP4 
               
               
                   
                 202637_s_at 
                 AI608725 
                 −1 
                 ICAM1 
               
               
                   
                 202638_s_at 
                 NM_000201 
                 −1 
                 ICAM1 
               
               
                   
                 202643_s_at 
                 AI738896 
                 −1 
                 TNFAIP3 
               
               
                   
                 202644_s_at 
                 NM_006290 
                 −1 
                 TNFAIP3 
               
               
                   
                 202859_x_at 
                 NM_000584 
                 −1 
                 IL8 
               
               
                   
                 202895_s_at 
                 D86043 
                 −1 
                 PTPNS1 
               
               
                   
                 202924_s_at 
                 AF006005 
                 −1 
                 PLAGL2 
               
               
                   
                 202925_s_at 
                 NM_002657 
                 −1 
                 PLAGL2 
               
               
                   
                 203317_at 
                 NM_012455 
                 −1 
                 PSD4 
               
               
                   
                 203394_s_at 
                 BE973687 
                 −1 
                 HES1 
               
               
                   
                 203470_s_at 
                 AI433595 
                 −1 
                 PLEK 
               
               
                   
                 203471_s_at 
                 NM_002664 
                 −1 
                 PLEK 
               
               
                   
                 203672_x_at 
                 U12387 
                 −1 
                 TPMT 
               
               
                   
                 203927_at 
                 NM_004556 
                 −1 
                 NFKBIE 
               
               
                   
                 204103_at 
                 NM_002984 
                 −1 
                 CCL4 
               
               
                   
                 204393_s_at 
                 NM_001099 
                 −1 
                 ACPP 
               
               
                   
                 204440_at 
                 NM_004233 
                 −1 
                 CD83 
               
               
                   
                 204469_at 
                 NM_002851 
                 −1 
                 PTPRZ1 
               
               
                   
                 204470_at 
                 NM_001511 
                 −1 
                 CXCL1 
               
               
                   
                 204533_at 
                 NM_001565 
                 −1 
                 CXCL10 
               
               
                   
                 204748_at 
                 NM_000963 
                 −1 
                 PTGS2 
               
               
                   
                 204794_at 
                 NM_004418 
                 −1 
                 DUSP2 
               
               
                   
                 204897_at 
                 AA897516 
                 −1 
                 PTGER4 
               
               
                   
                 204907_s_at 
                 AI829875 
                 −1 
                 BCL3 
               
               
                   
                 204970_s_at 
                 NM_002359 
                 −1 
                 MAFG 
               
               
                   
                 205045_at 
                 NM_007202 
                 −1 
                 AKAP10 
               
               
                   
                 205067_at 
                 NM_000576 
                 −1 
                 IL1B 
               
               
                   
                 205114_s_at 
                 NM_002983 
                 −1 
                 CCL3, CCL3L1 
               
               
                   
                 205115_s_at 
                 NM_016196 
                 −1 
                 RBM19 
               
               
                   
                 205207_at 
                 NM_000600 
                 −1 
                 IL6 
               
               
                   
                 205220_at 
                 NM_006018 
                 −1 
                 GPR109B 
               
               
                   
                 205318_at 
                 NM_004984 
                 −1 
                 KIF5A 
               
               
                   
                 205558_at 
                 NM_004620 
                 −1 
                 TRAF6 
               
               
                   
                 205643_s_at 
                 NM_004576 
                 −1 
                 PPP2R2B 
               
               
                   
                 205681_at 
                 NM_004049 
                 −1 
                 BCL2A1 
               
               
                   
                 205767_at 
                 NM_001432 
                 −1 
                 EREG 
               
               
                   
                 206025_s_at 
                 AW188198 
                 −1 
                 TNFAIP6 
               
               
                   
                 206087_x_at 
                 NM_000410 
                 −1 
                 HFE 
               
               
                   
                 206157_at 
                 NM_002852 
                 −1 
                 PTX3 
               
               
                   
                 206207_at 
                 NM_001828 
                 −1 
                 CLC 
               
               
                   
                 206256_at 
                 NM_001308 
                 −1 
                 CPN1 
               
               
                   
                 206295_at 
                 NM_001562 
                 −1 
                 IL18 
               
               
                   
                 206704_at 
                 NM_000084 
                 −1 
                 CLCN5 
               
               
                   
                 206765_at 
                 AF153820 
                 −1 
                 KCNJ2 
               
               
                   
                 206880_at 
                 NM_005446 
                 −1 
                 P2RXL1 
               
               
                   
                 207075_at 
                 NM_004895 
                 −1 
                 CIAS1 
               
               
                   
                 207113_s_at 
                 NM_000594 
                 −1 
                 TNF 
               
               
                   
                 207287_at 
                 NM_025026 
                 −1 
                 FLJ14107 
               
               
                   
                 207490_at 
                 NM_025019 
                 −1 
                 TUBA4 
               
               
                   
                 207535_s_at 
                 NM_002502 
                 −1 
                 NFKB2 
               
               
                   
                 207574_s_at 
                 NM_015675 
                 −1 
                 GADD45B 
               
               
                   
                 207850_at 
                 NM_002090 
                 −1 
                 CXCL3 
               
               
                   
                 207901_at 
                 NM_002187 
                 −1 
                 IL12B 
               
               
                   
                 207984_s_at 
                 NM_005374 
                 −1 
                 MPP2 
               
               
                   
                 208025_s_at 
                 NM_003483 
                 −1 
                 HMGA2 
               
               
                   
                 208039_at 
                 NM_003048 
                 −1 
                 NM_003048 
               
               
                   
                 208120_x_at 
                 NM_031221 
                 −1 
                 — 
               
               
                   
                 208455_at 
                 NM_002855 
                 −1 
                 PVRL1 
               
               
                   
                 208695_s_at 
                 BC001019 
                 −1 
                 RPL39 
               
               
                   
                 208886_at 
                 BC000145 
                 −1 
                 H1F0 
               
               
                   
                 208961_s_at 
                 AB017493 
                 −1 
                 COPEB 
               
               
                   
                 209034_at 
                 AF279899 
                 −1 
                 PNRC1 
               
               
                   
                 209039_x_at 
                 AF001434 
                 −1 
                 EHD1 
               
               
                   
                 209124_at 
                 U70451 
                 −1 
                 MYD88 
               
               
                   
                 209304_x_at 
                 AF087853 
                 −1 
                 GADD45B 
               
               
                   
                 209305_s_at 
                 AF078077 
                 −1 
                 GADD45B 
               
               
                   
                 209545_s_at 
                 AF027706 
                 −1 
                 RIPK2 
               
               
                   
                 209738_x_at 
                 M31125 
                 −1 
                 M31125 
               
               
                   
                 209774_x_at 
                 M57731 
                 −1 
                 CXCL2 
               
               
                   
                 209874_x_at 
                 AK023066 
                 −1 
                 CNNM2 
               
               
                   
                 209939_x_at 
                 AF005775 
                 −1 
                 CFLAR 
               
               
                   
                 210001_s_at 
                 AB005043 
                 −1 
                 SOCS1 
               
               
                   
                 210118_s_at 
                 M15329 
                 −1 
                 IL1A 
               
               
                   
                 210175_at 
                 BC000853 
                 −1 
                 C2orf3 
               
               
                   
                 210254_at 
                 L35848 
                 −1 
                 MS4A3 
               
               
                   
                 210275_s_at 
                 AF062347 
                 −1 
                 ZA20D2 
               
               
                   
                 210414_at 
                 AF169675 
                 −1 
                 FLRT1 
               
               
                   
                 210592_s_at 
                 M55580 
                 −1 
                 SAT 
               
               
                   
                 210651_s_at 
                 L41939 
                 −1 
                 EPHB2 
               
               
                   
                 211307_s_at 
                 U43677 
                 −1 
                 FCAR 
               
               
                   
                 211332_x_at 
                 AF144241 
                 −1 
                 HFE 
               
               
                   
                 211403_x_at 
                 AF167079 
                 −1 
                 VCX-(C,2,3); 
               
               
                   
                   
                   
                   
                 VCY 
               
               
                   
                 211434_s_at 
                 AF015524 
                 −1 
                 CCRL2 
               
               
                   
                 211506_s_at 
                 AF043337 
                 −1 
                 IL8 
               
               
                   
                 211578_s_at 
                 M60725 
                 −1 
                 RPS6KB1 
               
               
                   
                 211610_at 
                 U51869 
                 −1 
                 COPEB 
               
               
                   
                 213575_at 
                 AW978896 
                 −1 
                 TRA2A 
               
               
                   
                 215462_at 
                 AI978990 
                 −1 
                 LOC149478 
               
               
                   
                 211863_x_at 
                 AF079408 
                 −1 
                 HFE 
               
               
                   
                 211924_s_at 
                 AY029180 
                 −1 
                 PLAUR 
               
               
                   
                 211973_at 
                 AW341200 
                 −1 
                 NUDT3 
               
               
                   
                 212099_at 
                 AI263909 
                 −1 
                 RHOB 
               
               
                   
                 212291_at 
                 AI393355 
                 −1 
                 HIPK1 
               
               
                   
                 212602_at 
                 AI806395 
                 −1 
                 WDFY3 
               
               
                   
                 212657_s_at 
                 AW083357 
                 −1 
                 IL1RN 
               
               
                   
                 212659_s_at 
                 AW083357 
                 −1 
                 IL1RN 
               
               
                   
                 213002_at 
                 AA770596 
                 −1 
                 AA770596 
               
               
                   
                 213038_at 
                 AL031602 
                 −1 
                 IBRDC3 
               
               
                   
                 213146_at 
                 AA521267 
                 −1 
                 JMJD3 
               
               
                   
                 213281_at 
                 BE327172 
                 −1 
                 BE327172 
               
               
                   
                 213593_s_at 
                 AW978896 
                 −1 
                 TRA2A 
               
               
                   
                 213632_at 
                 M94065 
                 −1 
                 DHODH 
               
               
                   
                 213675_at 
                 W61005 
                 −1 
                 FLJ25106 
               
               
                   
                 213676_at 
                 AL038824 
                 −1 
                 AW125688 
               
               
                   
                 213988_s_at 
                 BE971383 
                 −1 
                 SAT 
               
               
                   
                 214211_at 
                 AA083483 
                 −1 
                 FTH1 
               
               
                   
                 214349_at 
                 AV764378 
                 −1 
                 ORF2 
               
               
                   
                 214421_x_at 
                 AV652420 
                 −1 
                 CYP2C9 
               
               
                   
                 214637_at 
                 BG437034 
                 −1 
                 OSM 
               
               
                   
                 214657_s_at 
                 AU134977 
                 −1 
                 TncRNA 
               
               
                   
                 215006_at 
                 AK023816 
                 −1 
                 EZH2 
               
               
                   
                 215078_at 
                 AL050388 
                 −1 
                 SOD2 
               
               
                   
                 215189_at 
                 X99142 
                 −1 
                 KRTHB6 
               
               
                   
                 215223_s_at 
                 W46388 
                 −1 
                 SOD2 
               
               
                   
                 215308_at 
                 AF052148 
                 −1 
                 G22P1 
               
               
                   
                 215485_s_at 
                 AA284705 
                 −1 
                 ICAM1 
               
               
                   
                 215577_at 
                 AU146791 
                 −1 
                 UBE2E1 
               
               
                   
                 215758_x_at 
                 AC007204 
                 −1 
                 ZNF505 
               
               
                   
                 215775_at 
                 BF084105 
                 −1 
                 BF084105 
               
               
                   
                 215899_at 
                 AK022331 
                 −1 
                 AK022331 
               
               
                   
                 215987_at 
                 AV654984 
                 −1 
                 AV654984 
               
               
                   
                 216015_s_at 
                 AK027194 
                 −1 
                 CIAS1 
               
               
                   
                 216016_at 
                 AK027194 
                 −1 
                 CIAS1 
               
               
                   
                 216084_at 
                 AL080137 
                 −1 
                 LOC389715 
               
               
                   
                 216114_at 
                 AL049430 
                 −1 
                 NCKIPSD 
               
               
                   
                 216153_x_at 
                 AK022897 
                 −1 
                 RECK 
               
               
                   
                 216243_s_at 
                 BE563442 
                 −1 
                 IL1RN 
               
               
                   
                 216336_x_at 
                 AL031602 
                 −1 
                 AL031602 
               
               
                   
                 216366_x_at 
                 AF047245 
                 −1 
                 AF047245 
               
               
                   
                 216438_s_at 
                 AL133228 
                 −1 
                 TMSB4X, 
               
               
                   
                   
                   
                   
                 TMSL3 
               
               
                   
                 216678_at 
                 AK000773 
                 −1 
                 AK000773 
               
               
                   
                 216774_at 
                 AK025325 
                 −1 
                 AK025325 
               
               
                   
                 216973_s_at 
                 S49765 
                 −1 
                 HOXB7 
               
               
                   
                 216997_x_at 
                 AL358975 
                 −1 
                 TLE4 
               
               
                   
                 217362_x_at 
                 AF005487 
                 −1 
                 HLA-DRB6 
               
               
                   
                 217415_at 
                 M21610 
                 −1 
                 M21610 
               
               
                   
                 217489_s_at 
                 S72848 
                 −1 
                 IL6R 
               
               
                   
                 217741_s_at 
                 NM_006007 
                 −1 
                 ZA20D2 
               
               
                   
                 217996_at 
                 NM_007350 
                 −1 
                 PHLDA1 
               
               
                   
                 218177_at 
                 NM_020412 
                 −1 
                 CHMP1.5 
               
               
                   
                 218198_at 
                 NM_018180 
                 −1 
                 DHX32 
               
               
                   
                 218611_at 
                 NM_016545 
                 −1 
                 IER5 
               
               
                   
                 218810_at 
                 NM_025079 
                 −1 
                 FLJ23231 
               
               
                   
                 219312_s_at 
                 NM_023929 
                 −1 
                 ZBTB10 
               
               
                   
                 219358_s_at 
                 NM_018404 
                 −1 
                 CENTA2 
               
               
                   
                 219397_at 
                 NM_025147 
                 −1 
                 FLJ13448 
               
               
                   
                 219450_at 
                 NM_018302 
                 −1 
                 FLJ11017 
               
               
                   
                 219617_at 
                 NM_024766 
                 −1 
                 FLJ23451 
               
               
                   
                 219901_at 
                 NM_018351 
                 −1 
                 FGD6 
               
               
                   
                 219935_at 
                 NM_007038 
                 −1 
                 ADAMTS5 
               
               
                   
                 220054_at 
                 NM_016584 
                 −1 
                 IL23A 
               
               
                   
                 220091_at 
                 NM_017585 
                 −1 
                 SLC2A6 
               
               
                   
                 220215_at 
                 NM_024804 
                 −1 
                 FLJ12606 
               
               
                   
                 220712_at 
                 NM_024984 
                 −1 
                 NM_024984 
               
               
                   
                 220737_at 
                 AF184965 
                 −1 
                 AF184965 
               
               
                   
                 220740_s_at 
                 NM_005135 
                 −1 
                 SLC12A6 
               
               
                   
                 220776_at 
                 NM_013348 
                 −1 
                 KCNJ14 
               
               
                   
                 220924_s_at 
                 NM_018976 
                 −1 
                 SLC38A2 
               
               
                   
                 221236_s_at 
                 NM_030795 
                 −1 
                 STMN4 
               
               
                   
                 221323_at 
                 NM_025218 
                 −1 
                 ULBP1 
               
               
                   
                 221345_at 
                 NM_005306 
                 −1 
                 GPR43 
               
               
                   
                 221477_s_at 
                 BC001980 
                 −1 
                 gasdermin 
               
               
                   
                 222136_x_at 
                 AK022905 
                 −1 
                 ZNF43 
               
               
                   
                 222303_at 
                 AV700891 
                 −1 
                 AV700891 
               
               
                   
                 222326_at 
                 AW973834 
                 −1 
                 AW973834 
               
               
                   
                 222329_x_at 
                 AW974816 
                 −1 
                 AW974816 
               
               
                   
                 36564_at 
                 W27419 
                 −1 
                 IBRDC3 
               
               
                   
                 37028_at 
                 U83981 
                 −1 
                 PPP1R15A 
               
               
                   
                 39402_at 
                 M15330 
                 −1 
                 IL1B 
               
               
                   
                 41386_i_at 
                 AB002344 
                 −1 
                 JMJD3 
               
               
                   
                 41387_r_at 
                 AB002344 
                 −1 
                 JMJD3 
               
               
                   
                 200023_s_at 
                 AI001896 
                 1 
                 EIF3S5 
               
               
                   
                 200028_s_at 
                 NM_020151 
                 1 
                 STARD7 
               
               
                   
                 200030_s_at 
                 NM_002635 
                 1 
                 SLC25A3 
               
               
                   
                 200083_at 
                 AA621731 
                 1 
                 USP22 
               
               
                   
                 200098_s_at 
                 T33068 
                 1 
                 ANAPC5 
               
               
                   
                 200609_s_at 
                 NM_017491 
                 1 
                 WDR1 
               
               
                   
                 200625_s_at 
                 NM_006367 
                 1 
                 CAP1 
               
               
                   
                 200688_at 
                 D13642 
                 1 
                 SF3B3 
               
               
                   
                 200816_s_at 
                 NM_000430 
                 1 
                 PAFAH1B1 
               
               
                   
                 200830_at 
                 NM_002808 
                 1 
                 PSMD2 
               
               
                   
                 200840_at 
                 NM_005548 
                 1 
                 KARS 
               
               
                   
                 200870_at 
                 NM_007178 
                 1 
                 STRAP 
               
               
                   
                 200899_s_at 
                 AK002091 
                 1 
                 MGEA5 
               
               
                   
                 200910_at 
                 NM_005998 
                 1 
                 CCT3 
               
               
                   
                 200932_s_at 
                 NM_006400 
                 1 
                 DCTN2 
               
               
                   
                 200961_at 
                 NM_012248 
                 1 
                 SEPHS2 
               
               
                   
                 201010_s_at 
                 NM_006472 
                 1 
                 TXNIP 
               
               
                   
                 201027_s_at 
                 NM_015904 
                 1 
                 EIF5B 
               
               
                   
                 201036_s_at 
                 NM_005327 
                 1 
                 HADHSC 
               
               
                   
                 201106_at 
                 NM_002085 
                 1 
                 GPX4 
               
               
                   
                 201174_s_at 
                 NM_018975 
                 1 
                 TERF2IP 
               
               
                   
                 201229_s_at 
                 BC000422 
                 1 
                 ARIH2 
               
               
                   
                 201405_s_at 
                 NM_006833 
                 1 
                 COPS6 
               
               
                   
                 201540_at 
                 NM_001449 
                 1 
                 FHL1 
               
               
                   
                 201541_s_at 
                 NM_006349 
                 1 
                 ZNHIT1 
               
               
                   
                 201569_s_at 
                 NM_015380 
                 1 
                 CGI-51 
               
               
                   
                 201612_at 
                 NM_000696 
                 1 
                 ALDH9A1 
               
               
                   
                 201672_s_at 
                 NM_005151 
                 1 
                 USP14 
               
               
                   
                 201688_s_at 
                 BG389015 
                 1 
                 TPD52 
               
               
                   
                 201689_s_at 
                 NM_005079 
                 1 
                 TPD52 
               
               
                   
                 202042_at 
                 NM_002109 
                 1 
                 HARS 
               
               
                   
                 202658_at 
                 NM_003846 
                 1 
                 PEX11B 
               
               
                   
                 202836_s_at 
                 BC001046 
                 1 
                 TXNL4A 
               
               
                   
                 204220_at 
                 NM_004877 
                 1 
                 GMFG 
               
               
                   
                 201805_at 
                 NM_002733 
                 1 
                 PRKAG1 
               
               
                   
                 201863_at 
                 NM_014077 
                 1 
                 FAM32A 
               
               
                   
                 201959_s_at 
                 AA488899 
                 1 
                 MYCBP2 
               
               
                   
                 201964_at 
                 N64643 
                 1 
                 N64643 
               
               
                   
                 202009_at 
                 NM_007284 
                 1 
                 PTK9L 
               
               
                   
                 202020_s_at 
                 NM_006055 
                 1 
                 LANCL1 
               
               
                   
                 202057_at 
                 AW051311 
                 1 
                 KPNA1 
               
               
                   
                 202116_at 
                 NM_006268 
                 1 
                 DPF2 
               
               
                   
                 202127_at 
                 AB011108 
                 1 
                 PRPF4B 
               
               
                   
                 202167_s_at 
                 NM_022362 
                 1 
                 MMS19L 
               
               
                   
                 202220_at 
                 NM_014949 
                 1 
                 KIAA0907 
               
               
                   
                 202244_at 
                 NM_002796 
                 1 
                 PSMB4 
               
               
                   
                 202259_s_at 
                 NM_014887 
                 1 
                 PFAAP5 
               
               
                   
                 202265_at 
                 NM_005180 
                 1 
                 BMI1 
               
               
                   
                 202271_at 
                 AB007952 
                 1 
                 AB007952 
               
               
                   
                 202296_s_at 
                 NM_007033 
                 1 
                 RER1 
               
               
                   
                 202306_at 
                 NM_002696 
                 1 
                 POLR2G 
               
               
                   
                 202342_s_at 
                 NM_015271 
                 1 
                 TRIM2 
               
               
                   
                 202353_s_at 
                 NM_002816 
                 1 
                 PSMD12 
               
               
                   
                 202365_at 
                 BC004815 
                 1 
                 MGC5139 
               
               
                   
                 202439_s_at 
                 NM_000202 
                 1 
                 IDS 
               
               
                   
                 202475_at 
                 NM_006326 
                 1 
                 NIFIE14 
               
               
                   
                 202529_at 
                 NM_002766 
                 1 
                 PRPSAP1 
               
               
                   
                 202560_s_at 
                 NM_015607 
                 1 
                 DKFZP547E1010 
               
               
                   
                 202564_x_at 
                 NM_001667 
                 1 
                 ARL2 
               
               
                   
                 202568_s_at 
                 AI745639 
                 1 
                 MARK3 
               
               
                   
                 202759_s_at 
                 BE879367 
                 1 
                 PALM2-AKAP2 
               
               
                   
                 202761_s_at 
                 NM_015180 
                 1 
                 SYNE2 
               
               
                   
                 202792_s_at 
                 NM_014678 
                 1 
                 KIAA0685 
               
               
                   
                 202811_at 
                 NM_006463 
                 1 
                 STAMBP 
               
               
                   
                 202892_at 
                 NM_004661 
                 1 
                 CDC23 
               
               
                   
                 202960_s_at 
                 NM_000255 
                 1 
                 MUT 
               
               
                   
                 202983_at 
                 AI760760 
                 1 
                 SMARCA3 
               
               
                   
                 203117_s_at 
                 NM_014871 
                 1 
                 USP52 
               
               
                   
                 203194_s_at 
                 NM_005387 
                 1 
                 NUP98 
               
               
                   
                 203221_at 
                 NM_005077 
                 1 
                 TLE1 
               
               
                   
                 203264_s_at 
                 NM_015185 
                 1 
                 ARHGEF9 
               
               
                   
                 203266_s_at 
                 NM_003010 
                 1 
                 MAP2K4 
               
               
                   
                 203301_s_at 
                 NM_021145 
                 1 
                 DMTF1 
               
               
                   
                 203378_at 
                 AB020631 
                 1 
                 PCF11 
               
               
                   
                 203445_s_at 
                 NM_005730 
                 1 
                 CTDSP2 
               
               
                   
                 203482_at 
                 AL133215 
                 1 
                 C10orf6 
               
               
                   
                 203487_s_at 
                 NM_015396 
                 1 
                 ARMC8 
               
               
                   
                 203517_at 
                 NM_006554 
                 1 
                 MTX2 
               
               
                   
                 203583_at 
                 NM_014044 
                 1 
                 UNC50 
               
               
                   
                 203683_s_at 
                 NM_003377 
                 1 
                 VEGFB 
               
               
                   
                 203710_at 
                 NM_002222 
                 1 
                 ITPR1 
               
               
                   
                 203721_s_at 
                 NM_016001 
                 1 
                 CGI-48 
               
               
                   
                 203738_at 
                 AI421192 
                 1 
                 FLJ11193 
               
               
                   
                 203775_at 
                 NM_014251 
                 1 
                 SLC25A13 
               
               
                   
                 203804_s_at 
                 NM_006107 
                 1 
                 CROP 
               
               
                   
                 203865_s_at 
                 NM_015833 
                 1 
                 ADARB1 
               
               
                   
                 203981_s_at 
                 AL574660 
                 1 
                 ABCD4 
               
               
                   
                 204000_at 
                 NM_016194 
                 1 
                 GNB5 
               
               
                   
                 204004_at 
                 AI336206 
                 1 
                 PAWR 
               
               
                   
                 204060_s_at 
                 NM_005044 
                 1 
                 PRKX, PRKY 
               
               
                   
                 204139_x_at 
                 NM_003422 
                 1 
                 ZNF42 
               
               
                   
                 204153_s_at 
                 AI738965 
                 1 
                 MFNG 
               
               
                   
                 204178_s_at 
                 NM_006328 
                 1 
                 RBM14 
               
               
                   
                 204185_x_at 
                 NM_005038 
                 1 
                 PPID 
               
               
                   
                 204202_at 
                 NM_017604 
                 1 
                 IQCE 
               
               
                   
                 204279_at 
                 NM_002800 
                 1 
                 PSMB9 
               
               
                   
                 204291_at 
                 NM_014803 
                 1 
                 ZNF518 
               
               
                   
                 204327_s_at 
                 NM_003455 
                 1 
                 ZNF202 
               
               
                   
                 204396_s_at 
                 NM_005308 
                 1 
                 GRK5 
               
               
                   
                 204410_at 
                 NM_004681 
                 1 
                 EIF1AY 
               
               
                   
                 204510_at 
                 NM_003503 
                 1 
                 CDC7 
               
               
                   
                 204528_s_at 
                 NM_004537 
                 1 
                 NAP1L1 
               
               
                   
                 204581_at 
                 NM_001771 
                 1 
                 CD22 
               
               
                   
                 204593_s_at 
                 AA046752 
                 1 
                 FLJ20232 
               
               
                   
                 204618_s_at 
                 NM_005254 
                 1 
                 GABPB2 
               
               
                   
                 204640_s_at 
                 NM_003563 
                 1 
                 SPOP 
               
               
                   
                 204772_s_at 
                 NM_007344 
                 1 
                 TTF1 
               
               
                   
                 204848_x_at 
                 NM_000559 
                 1 
                 HBG1, HBG2 
               
               
                   
                 204873_at 
                 NM_000466 
                 1 
                 PEX1 
               
               
                   
                 204950_at 
                 NM_014959 
                 1 
                 CARD8 
               
               
                   
                 205034_at 
                 NM_004702 
                 1 
                 CCNE2 
               
               
                   
                 205049_s_at 
                 NM_001783 
                 1 
                 CD79A 
               
               
                   
                 208985_s_at 
                 BC002719 
                 1 
                 EIF3S1 
               
               
                   
                 209685_s_at 
                 M13975 
                 1 
                 PRKCB1 
               
               
                   
                 205296_at 
                 AL365505 
                 1 
                 RBL1 
               
               
                   
                 205297_s_at 
                 NM_000626 
                 1 
                 CD79B 
               
               
                   
                 205353_s_at 
                 NM_002567 
                 1 
                 PBP 
               
               
                   
                 205612_at 
                 NM_007351 
                 1 
                 MMRN1 
               
               
                   
                 205671_s_at 
                 NM_002120 
                 1 
                 HLA-DOB 
               
               
                   
                 205788_s_at 
                 NM_014827 
                 1 
                 NM_014827 
               
               
                   
                 205790_at 
                 NM_003726 
                 1 
                 SCAP1 
               
               
                   
                 205933_at 
                 NM_015559 
                 1 
                 SETBP1 
               
               
                   
                 206272_at 
                 NM_006542 
                 1 
                 SPHAR 
               
               
                   
                 206493_at 
                 NM_000419 
                 1 
                 ITGA2B 
               
               
                   
                 206494_s_at 
                 NM_000419 
                 1 
                 ITGA2B 
               
               
                   
                 206652_at 
                 NM_016384 
                 1 
                 DKFZp779H233 
               
               
                   
                 206854_s_at 
                 NM_003188 
                 1 
                 MAP3K7 
               
               
                   
                 207081_s_at 
                 NM_002650 
                 1 
                 PIK4CA 
               
               
                   
                 207170_s_at 
                 NM_015416 
                 1 
                 LETMD1 
               
               
                   
                 207180_s_at 
                 NM_006410 
                 1 
                 HTATIP2 
               
               
                   
                 207314_x_at 
                 NM_006737 
                 1 
                 KIR3DL2 
               
               
                   
                 207405_s_at 
                 NM_002873 
                 1 
                 RAD17 
               
               
                   
                 207522_s_at 
                 NM_005173 
                 1 
                 ATP2A3 
               
               
                   
                 207655_s_at 
                 NM_013314 
                 1 
                 BLNK 
               
               
                   
                 207812_s_at 
                 NM_015530 
                 1 
                 GORASP2 
               
               
                   
                 207830_s_at 
                 NM_002713 
                 1 
                 PPP1R8 
               
               
                   
                 207842_s_at 
                 NM_007359 
                 1 
                 CASC3 
               
               
                   
                 208073_x_at 
                 NM_003316 
                 1 
                 TTC3 
               
               
                   
                 208184_s_at 
                 NM_003274 
                 1 
                 TMEM1 
               
               
                   
                 208622_s_at 
                 AA670344 
                 1 
                 VIL2 
               
               
                   
                 208640_at 
                 BG292367 
                 1 
                 RAC1 
               
               
                   
                 208651_x_at 
                 BG327863 
                 1 
                 CD24 
               
               
                   
                 208722_s_at 
                 BC001081 
                 1 
                 ANAPC5 
               
               
                   
                 208752_x_at 
                 AI888672 
                 1 
                 NAP1L1 
               
               
                   
                 208758_at 
                 D89976 
                 1 
                 ATIC 
               
               
                   
                 208792_s_at 
                 M25915 
                 1 
                 CLU 
               
               
                   
                 208809_s_at 
                 AL136632 
                 1 
                 C6orf62 
               
               
                   
                 208837_at 
                 BC000027 
                 1 
                 C15orf22 
               
               
                   
                 209007_s_at 
                 AF247168 
                 1 
                 NPD014 
               
               
                   
                 209058_at 
                 AB002282 
                 1 
                 EDF1 
               
               
                   
                 209075_s_at 
                 AY009128 
                 1 
                 ISCU 
               
               
                   
                 209139_s_at 
                 AF083033 
                 1 
                 PRKRA 
               
               
                   
                 209153_s_at 
                 M31523 
                 1 
                 TCF3 
               
               
                   
                 209215_at 
                 L11669 
                 1 
                 TETRAN 
               
               
                   
                 209234_at 
                 BF939474 
                 1 
                 KIF1B 
               
               
                   
                 209273_s_at 
                 BG387555 
                 1 
                 HBLD2 
               
               
                   
                 209284_s_at 
                 AI922509 
                 1 
                 RAP140 
               
               
                   
                 209340_at 
                 S73498 
                 1 
                 UAP1 
               
               
                   
                 209431_s_at 
                 AF254083 
                 1 
                 ZNF278 
               
               
                   
                 209447_at 
                 AF043290 
                 1 
                 SYNE1 
               
               
                   
                 209449_at 
                 AF196468 
                 1 
                 LSM2 
               
               
                   
                 209452_s_at 
                 AF035824 
                 1 
                 VTI1B 
               
               
                   
                 209482_at 
                 BC001430 
                 1 
                 POP7 
               
               
                   
                 209486_at 
                 BC004546 
                 1 
                 SAS10 
               
               
                   
                 209503_s_at 
                 AF035309 
                 1 
                 PSMC5 
               
               
                   
                 209549_s_at 
                 BC001121 
                 1 
                 DGUOK 
               
               
                   
                 209572_s_at 
                 AF080227 
                 1 
                 EED 
               
               
                   
                 209625_at 
                 BC004100 
                 1 
                 PIGH 
               
               
                   
                 209630_s_at 
                 U87460 
                 1 
                 FBXW2 
               
               
                   
                 209659_s_at 
                 AF164598 
                 1 
                 CDC16 
               
               
                   
                 209729_at 
                 BC001782 
                 1 
                 GAS2L1 
               
               
                   
                 209771_x_at 
                 AA761181 
                 1 
                 CD24 
               
               
                   
                 209778_at 
                 AF007217 
                 1 
                 TRIP11 
               
               
                   
                 209903_s_at 
                 U49844 
                 1 
                 ATR 
               
               
                   
                 209917_s_at 
                 BC002709 
                 1 
                 TP53AP1 
               
               
                   
                 210046_s_at 
                 U52144 
                 1 
                 IDH2 
               
               
                   
                 210356_x_at 
                 BC002807 
                 1 
                 MS4A1 
               
               
                   
                 210378_s_at 
                 BC004118 
                 1 
                 SSNA1 
               
               
                   
                 210627_s_at 
                 BC002804 
                 1 
                 GCS1 
               
               
                   
                 210690_at 
                 U96845 
                 1 
                 KLRC4 
               
               
                   
                 210715_s_at 
                 AF027205 
                 1 
                 SPINT2 
               
               
                   
                 210719_s_at 
                 BC002552 
                 1 
                 HMG20B 
               
               
                   
                 210886_x_at 
                 AB007457 
                 1 
                 TP53AP1 
               
               
                   
                 210927_x_at 
                 BC004239 
                 1 
                 JTB 
               
               
                   
                 211036_x_at 
                 BC006301 
                 1 
                 ANAPC5 
               
               
                   
                 211479_s_at 
                 M81778 
                 1 
                 HTR2C 
               
               
                   
                 211881_x_at 
                 AB014341 
                 1 
                 IGLJ3 
               
               
                   
                 213351_s_at 
                 AB018322 
                 1 
                 KIAA0779 
               
               
                   
                 213364_s_at 
                 AI052536 
                 1 
                 SNX1 
               
               
                   
                 211784_s_at 
                 BC006181 
                 1 
                 SFRS1 
               
               
                   
                 211945_s_at 
                 BG500301 
                 1 
                 ITGB1 
               
               
                   
                 211954_s_at 
                 BC000947 
                 1 
                 RANBP5 
               
               
                   
                 211979_at 
                 AB046844 
                 1 
                 GPR107 
               
               
                   
                 212040_at 
                 BG249599 
                 1 
                 TGOLN2 
               
               
                   
                 212068_s_at 
                 AB011087 
                 1 
                 KIAA0515 
               
               
                   
                 212114_at 
                 BE967207 
                 1 
                 microtubule 
               
               
                   
                   
                   
                   
                 protein 
               
               
                   
                 212121_at 
                 BE962354 
                 1 
                 C10orf61 
               
               
                   
                 212140_at 
                 AB014548 
                 1 
                 SCC-112 
               
               
                   
                 212201_at 
                 AW274877 
                 1 
                 KIAA0692 
               
               
                   
                 212244_at 
                 AL050091 
                 1 
                 GRINL1A 
               
               
                   
                 212247_at 
                 AW008531 
                 1 
                 NUP205 
               
               
                   
                 212321_at 
                 BE999972 
                 1 
                 BE999972 
               
               
                   
                 212326_at 
                 AB007922 
                 1 
                 VPS13D 
               
               
                   
                 212361_s_at 
                 AA805753 
                 1 
                 ATP2A2 
               
               
                   
                 212548_s_at 
                 BF515124 
                 1 
                 KIAA0826 
               
               
                   
                 212559_at 
                 AU148827 
                 1 
                 AU148827 
               
               
                   
                 212566_at 
                 AL523310 
                 1 
                 MAP4 
               
               
                   
                 212583_at 
                 AB011132 
                 1 
                 AB011132 
               
               
                   
                 212611_at 
                 AV728526 
                 1 
                 DTX4 
               
               
                   
                 212632_at 
                 N32035 
                 1 
                 STX7 
               
               
                   
                 212655_at 
                 AB011151 
                 1 
                 ZCCHC14 
               
               
                   
                 212667_at 
                 AL575922 
                 1 
                 SPARC 
               
               
                   
                 212690_at 
                 AB018268 
                 1 
                 DDHD2 
               
               
                   
                 212714_at 
                 AL050205 
                 1 
                 LOC113251 
               
               
                   
                 212750_at 
                 AB020630 
                 1 
                 PPP1R16B 
               
               
                   
                 212760_at 
                 AB002347 
                 1 
                 C6orf133 
               
               
                   
                 212813_at 
                 AA149644 
                 1 
                 JAM3 
               
               
                   
                 212855_at 
                 D87466 
                 1 
                 KIAA0276 
               
               
                   
                 212955_s_at 
                 AL037557 
                 1 
                 POLR2I 
               
               
                   
                 213061_s_at 
                 AA643304 
                 1 
                 NTAN1 
               
               
                   
                 213065_at 
                 AB011118 
                 1 
                 MGC23401 
               
               
                   
                 213088_s_at 
                 BE551340 
                 1 
                 DNAJC9 
               
               
                   
                 213090_s_at 
                 AI744029 
                 1 
                 TAF4 
               
               
                   
                 213106_at 
                 AI769688 
                 1 
                 ATP8A1 
               
               
                   
                 213165_at 
                 AI041204 
                 1 
                 CAP350 
               
               
                   
                 213213_at 
                 AL035669 
                 1 
                 DATF1 
               
               
                   
                 213267_at 
                 AL162056 
                 1 
                 KIAA1117 
               
               
                   
                 213278_at 
                 AW014788 
                 1 
                 MTMR9 
               
               
                   
                 213375_s_at 
                 N80918 
                 1 
                 CG018 
               
               
                   
                 213408_s_at 
                 AK024034 
                 1 
                 PIK4CA 
               
               
                   
                 213410_at 
                 AL050102 
                 1 
                 C10orf137 
               
               
                   
                 213460_x_at 
                 N29665 
                 1 
                 WBSCR20C 
               
               
                   
                 213483_at 
                 AK025679 
                 1 
                 KIAA0073 
               
               
                   
                 213515_x_at 
                 AI133353 
                 1 
                 HBG2 
               
               
                   
                 213528_at 
                 AL035369 
                 1 
                 MGC9084 
               
               
                   
                 213626_at 
                 AL049442 
                 1 
                 CBR4 
               
               
                   
                 213634_s_at 
                 AL031588 
                 1 
                 TRMT1 
               
               
                   
                 213653_at 
                 AW069290 
                 1 
                 METTL3 
               
               
                   
                 213659_at 
                 AA209420 
                 1 
                 ZNF75 
               
               
                   
                 213672_at 
                 AA621558 
                 1 
                 MARS 
               
               
                   
                 213838_at 
                 AA191426 
                 1 
                 AA191426 
               
               
                   
                 214130_s_at 
                 AI821791 
                 1 
                 PDE4DIP 
               
               
                   
                 214669_x_at 
                 BG485135 
                 1 
                 BG485135 
               
               
                   
                 214749_s_at 
                 AK000818 
                 1 
                 ARMCX6 
               
               
                   
                 214948_s_at 
                 AL050136 
                 1 
                 TMF1 
               
               
                   
                 215158_s_at 
                 AK022531 
                 1 
                 DEDD 
               
               
                   
                 215227_x_at 
                 BG035989 
                 1 
                 ACP1 
               
               
                   
                 215318_at 
                 AL049782 
                 1 
                 CG012 
               
               
                   
                 215343_at 
                 AF070587 
                 1 
                 0610010D24Rik 
               
               
                   
                 215648_at 
                 AU144324 
                 1 
                 KIAA1068 
               
               
                   
                 215925_s_at 
                 AF283777 
                 1 
                 CD72 
               
               
                   
                 216237_s_at 
                 AA807529 
                 1 
                 MCM5 
               
               
                   
                 216261_at 
                 AI151479 
                 1 
                 ITGB3 
               
               
                   
                 216338_s_at 
                 AK021433 
                 1 
                 C6orf109 
               
               
                   
                 218100_s_at 
                 NM_018010 
                 1 
                 ESRRBL1 
               
               
                   
                 219802_at 
                 NM_024854 
                 1 
                 FLJ22028 
               
               
                   
                 216379_x_at 
                 AK000168 
                 1 
                 CD24 
               
               
                   
                 216907_x_at 
                 X93596 
                 1 
                 KIR3DL2 
               
               
                   
                 216956_s_at 
                 AF098114 
                 1 
                 ITGA2B 
               
               
                   
                 217043_s_at 
                 U95822 
                 1 
                 MFN1 
               
               
                   
                 217418_x_at 
                 X12530 
                 1 
                 MS4A1 
               
               
                   
                 217645_at 
                 AW088547 
                 1 
                 AW088547 
               
               
                   
                 217730_at 
                 NM_022152 
                 1 
                 PP1201 
               
               
                   
                 217772_s_at 
                 NM_014342 
                 1 
                 MTCH2 
               
               
                   
                 217792_at 
                 NM_014426 
                 1 
                 SNX5 
               
               
                   
                 217815_at 
                 NM_007192 
                 1 
                 SUPT16H 
               
               
                   
                 217896_s_at 
                 NM_024946 
                 1 
                 NIP30 
               
               
                   
                 217906_at 
                 NM_014315 
                 1 
                 KLHDC2 
               
               
                   
                 217908_s_at 
                 NM_018442 
                 1 
                 IQWD1 
               
               
                   
                 217938_s_at 
                 AI743396 
                 1 
                 KCMF1 
               
               
                   
                 217978_s_at 
                 NM_017582 
                 1 
                 UBE2Q 
               
               
                   
                 217979_at 
                 NM_014399 
                 1 
                 TM4SF13 
               
               
                   
                 217986_s_at 
                 AA102574 
                 1 
                 BAZ1A 
               
               
                   
                 218004_at 
                 NM_018045 
                 1 
                 FLJ10276 
               
               
                   
                 218082_s_at 
                 NM_014517 
                 1 
                 UBP1 
               
               
                   
                 218124_at 
                 NM_017750 
                 1 
                 FLJ20296 
               
               
                   
                 218132_s_at 
                 NM_024075 
                 1 
                 LENG5 
               
               
                   
                 218179_s_at 
                 NM_021942 
                 1 
                 FLJ12716 
               
               
                   
                 218212_s_at 
                 NM_004531 
                 1 
                 MOCS2 
               
               
                   
                 218220_at 
                 NM_021640 
                 1 
                 C12orf10 
               
               
                   
                 218237_s_at 
                 NM_030674 
                 1 
                 SLC38A1 
               
               
                   
                 218250_s_at 
                 NM_013354 
                 1 
                 CNOT7 
               
               
                   
                 218301_at 
                 NM_018226 
                 1 
                 RNPEPL1 
               
               
                   
                 218328_at 
                 NM_016035 
                 1 
                 COQ4 
               
               
                   
                 218339_at 
                 NM_014180 
                 1 
                 MRPL22 
               
               
                   
                 218361_at 
                 NM_018178 
                 1 
                 GPP34R 
               
               
                   
                 218371_s_at 
                 AA969958 
                 1 
                 PSPC1 
               
               
                   
                 218432_at 
                 NM_012175 
                 1 
                 FBXO3 
               
               
                   
                 218440_at 
                 NM_020166 
                 1 
                 MCCC1 
               
               
                   
                 218456_at 
                 NM_023925 
                 1 
                 C1QDC1 
               
               
                   
                 218462_at 
                 NM_025065 
                 1 
                 RPF1 
               
               
                   
                 218504_at 
                 NM_016044 
                 1 
                 FAHD2A 
               
               
                   
                 218533_s_at 
                 NM_017859 
                 1 
                 UCKL1 
               
               
                   
                 218575_at 
                 NM_022662 
                 1 
                 ANAPC1 
               
               
                   
                 218607_s_at 
                 NM_018115 
                 1 
                 SDAD1 
               
               
                   
                 218608_at 
                 NM_022089 
                 1 
                 HSA9947 
               
               
                   
                 218626_at 
                 NM_019843 
                 1 
                 EIF4ENIF1 
               
               
                   
                 218639_s_at 
                 NM_025112 
                 1 
                 MGC11349 
               
               
                   
                 218654_s_at 
                 NM_016071 
                 1 
                 MRPS33 
               
               
                   
                 218667_at 
                 NM_022368 
                 1 
                 PJA1 
               
               
                   
                 218679_s_at 
                 NM_016208 
                 1 
                 VPS28 
               
               
                   
                 218771_at 
                 NM_018216 
                 1 
                 PANK4 
               
               
                   
                 219067_s_at 
                 NM_017615 
                 1 
                 C10orf86 
               
               
                   
                 219126_at 
                 NM_018288 
                 1 
                 PHF10 
               
               
                   
                 219151_s_at 
                 NM_007081 
                 1 
                 RABL2A, 
               
               
                   
                   
                   
                   
                 RABL2B 
               
               
                   
                 219180_s_at 
                 AI817074 
                 1 
                 PEX26 
               
               
                   
                 219185_at 
                 NM_012241 
                 1 
                 SIRT5 
               
               
                   
                 219283_at 
                 NM_014158 
                 1 
                 C1GALT2 
               
               
                   
                 219292_at 
                 NM_018105 
                 1 
                 THAP1 
               
               
                   
                 219317_at 
                 NM_007195 
                 1 
                 POLI 
               
               
                   
                 219470_x_at 
                 NM_019084 
                 1 
                 CCNJ 
               
               
                   
                 219581_at 
                 NM_025265 
                 1 
                 SEN2L 
               
               
                   
                 219627_at 
                 NM_024910 
                 1 
                 FLJ12700 
               
               
                   
                 219822_at 
                 NM_004294 
                 1 
                 MTRF1 
               
               
                   
                 219880_at 
                 NM_022907 
                 1 
                 FLJ23053 
               
               
                   
                 219979_s_at 
                 NM_016401 
                 1 
                 HSPC138 
               
               
                   
                 220044_x_at 
                 NM_016424 
                 1 
                 CROP 
               
               
                   
                 220059_at 
                 NM_012108 
                 1 
                 BRDG1 
               
               
                   
                 220169_at 
                 NM_024943 
                 1 
                 FLJ23235 
               
               
                   
                 220216_at 
                 NM_019607 
                 1 
                 FLJ11267 
               
               
                   
                 220261_s_at 
                 NM_018106 
                 1 
                 ZDHHC4 
               
               
                   
                 220387_s_at 
                 NM_007071 
                 1 
                 HHLA3 
               
               
                   
                 220418_at 
                 NM_018961 
                 1 
                 UBASH3A 
               
               
                   
                 220936_s_at 
                 NM_018267 
                 1 
                 H2AFJ 
               
               
                   
                 221208_s_at 
                 NM_024631 
                 1 
                 FLJ23342 
               
               
                   
                 221253_s_at 
                 NM_030810 
                 1 
                 TXNDC5 
               
               
                   
                 221476_s_at 
                 AF279903 
                 1 
                 RPL15 
               
               
                   
                 221515_s_at 
                 BC001214 
                 1 
                 LCMT1 
               
               
                   
                 221516_s_at 
                 BC002587 
                 1 
                 FLJ20232 
               
               
                   
                 221548_s_at 
                 AY024365 
                 1 
                 ILKAP 
               
               
                   
                 221586_s_at 
                 U15642 
                 1 
                 E2F5 
               
               
                   
                 221736_at 
                 BG236163 
                 1 
                 KIAA1219 
               
               
                   
                 221791_s_at 
                 BG167522 
                 1 
                 HSPC016 
               
               
                   
                 221811_at 
                 BF033007 
                 1 
                 PERLD1 
               
               
                   
                 221932_s_at 
                 AA133341 
                 1 
                 C14orf87 
               
               
                   
                 222111_at 
                 AU145293 
                 1 
                 KIAA1164 
               
               
                   
                 222130_s_at 
                 AK024635 
                 1 
                 FTSJ2 
               
               
                   
                 222155_s_at 
                 AK021918 
                 1 
                 GPR172A 
               
               
                   
                 222233_s_at 
                 AK022922 
                 1 
                 DCLRE1C 
               
               
                   
                 222273_at 
                 AI419423 
                 1 
                 AI419423 
               
               
                   
                 266_s_at 
                 L33930 
                 1 
                 CD24 
               
               
                   
                 32259_at 
                 AB002386 
                 1 
                 EZH1 
               
               
                   
                 33307_at 
                 AL022316 
                 1 
                 CGI-96 
               
               
                   
                 37965_at 
                 AA181053 
                 1 
                 PARVB 
               
               
                   
                 37966_at 
                 AA187563 
                 1 
                 PARVB 
               
               
                   
                 38043_at 
                 X55448 
                 1 
                 FAM3A 
               
               
                   
                 45828_at 
                 AI768100 
                 1 
                 FLJ10241 
               
               
                   
                 48825_at 
                 AA887083 
                 1 
                 ING4 
               
               
                   
                 50374_at 
                 AA150503 
                 1 
                 LOC339229 
               
               
                   
                 52164_at 
                 AA065185 
                 1 
                 C11orf24 
               
               
                   
                 64432_at 
                 W05463 
                 1 
                 FLJ39616 
               
               
                   
                 65472_at 
                 AI161338 
                 1 
                 AI161338 
               
               
                   
                   
               
               
                   
                 Table 1: Provided are genetic markers which are differentially expressed between subjects diagnosed with probable multiple sclerosis and healthy controls (the Probeset ID of the Affymetrix Gene Chip), along with the corresponding GenBank accession number (GenBank Acc. No.), the gene symbol and the direction (Dir) of change in gene expression (“1”- upregulation; “−1” - downregulation). Note that the p values of the TNOM, Info and t-Test statistical tests all passed the 95% confidence level. 
               
            
           
         
       
     
     Independent verification by support vector machine (SVM)—Verification of the probable PBMC gene expression signature (554 genes) was performed on an independent group of 15 subjects (12 patients, 3 controls) by SVM analysis and resulted in high classification rate of 80%. These findings suggest that the identified gene expression signature in probable MS is reliable and not related to spurious difference due to multiple testing. 
     Example 2 
     Gene Expression Analysis of Subjects Whose Diagnosis Converted to Definite MS or Sustained Probable MS 
     Experimental Results 
     Conversion to definite MS—2-year results—During the follow up period of 2 year, 30% of patients (12/40) experienced a second attack and progressed to definite MS disease (defined as early convectors to definite MS). Comparison of the gene expression pattern of only these probable patients who further experienced a second attack and therefore defined as definite MS (12 patients) (using the blood cell samples obtained when the subjects were defined as probable multiple sclerosis, i.e., after the first neurological attack) to matched control group (11 subjects) identified 1517 most informative genes (Table 2, hereinbelow and  FIG. 2   a ), all passed FDR at p&lt;0.03 and 8 genes—Bonfferoni correction at p&lt;3.2×10 −5 . PCA performed on these 1517 most informative genes demonstrated correct classification rate with no errors ( FIG. 2   b ). 
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 Differentially expressed markers between probable multiple sclerosis 
               
               
                 subjects which further developed definite multiple sclerosis and 
               
               
                 healthy controls 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                 GenBank 
                   
                   
               
               
                   
                 Probeset 
                 Acc. No. 
                 Dir 
                 Gene Symbol 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 214376_at 
                 AI263044 
                 −1 
                 AI263044 
               
               
                   
                 217446_x_at 
                 AL080160 
                 −1 
                 AL080160 
               
               
                   
                 215185_at 
                 AK024177 
                 −1 
                 AK024177 
               
               
                   
                 217449_at 
                 AL137284 
                 −1 
                 DKFZp434D1516 
               
               
                   
                 221877_at 
                 BF508835 
                 −1 
                 FKSG27 
               
               
                   
                 222135_at 
                 AK022663 
                 −1 
                 KIAA1956 
               
               
                   
                 217381_s_at 
                 X69383 
                 −1 
                 T-cell receptor 
               
               
                   
                   
                   
                   
                 gamma 
               
               
                   
                 221477_s_at 
                 BC001980 
                 −1 
                 NP_079012.2 
               
               
                   
                 215995_x_at 
                 AU147598 
                 −1 
                 LOC283585 
               
               
                   
                 214826_at 
                 U79276 
                 −1 
                 2′-PDE 
               
               
                   
                 44702_at 
                 R77097 
                 −1 
                 7h3 
               
               
                   
                 201269_s_at 
                 AB028991 
                 −1 
                 AB028991 
               
               
                   
                 214979_at 
                 AK000791 
                 −1 
                 ABCC3 
               
               
                   
                 205566_at 
                 NM_007011 
                 −1 
                 ABHD2 
               
               
                   
                 207268_x_at 
                 NM_005759 
                 −1 
                 ABI2 
               
               
                   
                 217024_x_at 
                 AC004832 
                 −1 
                 AC004832 
               
               
                   
                 206776_x_at 
                 NM_001612 
                 −1 
                 ACRV1 
               
               
                   
                 207973_x_at 
                 NM_020110 
                 −1 
                 ACRV1 
               
               
                   
                 207990_x_at 
                 NM_020114 
                 −1 
                 ACRV1 
               
               
                   
                 207991_x_at 
                 NM_020113 
                 −1 
                 ACRV1 
               
               
                   
                 211489_at 
                 D32201 
                 −1 
                 ADRA1A 
               
               
                   
                 38447_at 
                 U08438 
                 −1 
                 ADRBK1 
               
               
                   
                 201205_at 
                 AF006751 
                 −1 
                 AF006751 
               
               
                   
                 216366_x_at 
                 AF047245 
                 −1 
                 AF047245 
               
               
                   
                 211189_x_at 
                 AF054816 
                 −1 
                 AF054816 
               
               
                   
                 215837_x_at 
                 AF113018 
                 −1 
                 AF113018 
               
               
                   
                 208849_at 
                 AF118091 
                 −1 
                 AF118091 
               
               
                   
                 219558_at 
                 NM_024524 
                 −1 
                 AFURS1 
               
               
                   
                 205357_s_at 
                 NM_000685 
                 −1 
                 AGTR1 
               
               
                   
                 207464_at 
                 NM_014121 
                 −1 
                 AHCYL1 
               
               
                   
                 214139_at 
                 AI051476 
                 −1 
                 AI051476 
               
               
                   
                 221960_s_at 
                 AI189609 
                 −1 
                 AI189609 
               
               
                   
                 214379_at 
                 AI954458 
                 −1 
                 AI954458 
               
               
                   
                 216678_at 
                 AK000773 
                 −1 
                 AK000773 
               
               
                   
                 216682_s_at 
                 AK021457 
                 −1 
                 AK021457 
               
               
                   
                 216051_x_at 
                 AK022045 
                 −1 
                 AK022045 
               
               
                   
                 217335_at 
                 AK023539 
                 −1 
                 AK023539 
               
               
                   
                 216739_at 
                 AK024527 
                 −1 
                 AK024527 
               
               
                   
                 216746_at 
                 AK024606 
                 −1 
                 AK024606 
               
               
                   
                 216437_at 
                 AK024949 
                 −1 
                 AK024949 
               
               
                   
                 215405_at 
                 AK025072 
                 −1 
                 AK025072 
               
               
                   
                 216774_at 
                 AK025325 
                 −1 
                 AK025325 
               
               
                   
                 217218_at 
                 AK027005 
                 −1 
                 AK027005 
               
               
                   
                 210517_s_at 
                 AB003476 
                 −1 
                 AKAP12 
               
               
                   
                 205359_at 
                 NM_004274 
                 −1 
                 AKAP6 
               
               
                   
                 211172_x_at 
                 AF161075 
                 −1 
                 AKAP7 
               
               
                   
                 204151_x_at 
                 NM_001353 
                 −1 
                 AKR1C1 
               
               
                   
                 216336_x_at 
                 AL031602 
                 −1 
                 AL031602 
               
               
                   
                 41856_at 
                 AL049370 
                 −1 
                 AL049370 
               
               
                   
                 216499_at 
                 AL137590 
                 −1 
                 AL137590 
               
               
                   
                 216828_at 
                 AL441988 
                 −1 
                 AL441988 
               
               
                   
                 210544_s_at 
                 BC002430 
                 −1 
                 ALDH3A2 
               
               
                   
                 214423_x_at 
                 AV652403 
                 −1 
                 ALDOB 
               
               
                   
                 207755_at 
                 NM_025017 
                 −1 
                 AMOTL2 
               
               
                   
                 213001_at 
                 AF007150 
                 −1 
                 ANGPTL2 
               
               
                   
                 218418_s_at 
                 NM_015493 
                 −1 
                 ANKRD25 
               
               
                   
                 203074_at 
                 NM_001630 
                 −1 
                 ANXA8 
               
               
                   
                 211553_x_at 
                 AF149794 
                 −1 
                 APAF1 
               
               
                   
                 206350_at 
                 NM_001639 
                 −1 
                 APCS 
               
               
                   
                 202914_s_at 
                 NM_014784 
                 −1 
                 ARHGEF11 
               
               
                   
                 207919_at 
                 NM_004314 
                 −1 
                 ART1 
               
               
                   
                 202672_s_at 
                 NM_001674 
                 −1 
                 ATF3 
               
               
                   
                 216070_at 
                 AL049331 
                 −1 
                 ATP1B1 
               
               
                   
                 214132_at 
                 BG232034 
                 −1 
                 ATP5C1 
               
               
                   
                 204624_at 
                 NM_000053 
                 −1 
                 ATP7B 
               
               
                   
                 222303_at 
                 AV700891 
                 −1 
                 AV700891 
               
               
                   
                 206251_s_at 
                 NM_000706 
                 −1 
                 AVPR1A 
               
               
                   
                 212999_x_at 
                 AW276186 
                 −1 
                 AW276186 
               
               
                   
                 222363_at 
                 AW979018 
                 −1 
                 AW979018 
               
               
                   
                 219326_s_at 
                 AF288208 
                 −1 
                 B3GNT1 
               
               
                   
                 209413_at 
                 BC002431 
                 −1 
                 B4GALT2 
               
               
                   
                 91920_at 
                 AI205180 
                 −1 
                 BCAN 
               
               
                   
                 219444_at 
                 NM_021946 
                 −1 
                 BCORL1 
               
               
                   
                 213281_at 
                 BE327172 
                 −1 
                 BE327172 
               
               
                   
                 221917_s_at 
                 BF058465 
                 −1 
                 BF058465 
               
               
                   
                 213561_at 
                 BF062335 
                 −1 
                 BF062335 
               
               
                   
                 215775_at 
                 BF084105 
                 −1 
                 BF084105 
               
               
                   
                 212002_at 
                 BG171020 
                 −1 
                 BG171020 
               
               
                   
                 220580_at 
                 NM_025044 
                 −1 
                 BICC1 
               
               
                   
                 218955_at 
                 NM_018310 
                 −1 
                 BRF2 
               
               
                   
                 201235_s_at 
                 BG339064 
                 −1 
                 BTG2 
               
               
                   
                 215072_x_at 
                 AK025270 
                 −1 
                 C10orf137 
               
               
                   
                 43934_at 
                 AA479495 
                 −1 
                 C11ORF4 
               
               
                   
                 219720_s_at 
                 NM_017972 
                 −1 
                 C14orf118 
               
               
                   
                 215219_at 
                 AK025095 
                 −1 
                 C21orf5 
               
               
                   
                 48030_i_at 
                 H93077 
                 −1 
                 C5orf4 
               
               
                   
                 220231_at 
                 NM_006658 
                 −1 
                 C7orf16 
               
               
                   
                 61874_at 
                 AL042496 
                 −1 
                 C9orf7 
               
               
                   
                 205949_at 
                 M33987 
                 −1 
                 CA1 
               
               
                   
                 205199_at 
                 NM_001216 
                 −1 
                 CA9 
               
               
                   
                 214845_s_at 
                 AF257659 
                 −1 
                 CALU 
               
               
                   
                 34846_at 
                 AF112472 
                 −1 
                 CAMK2B 
               
               
                   
                 210787_s_at 
                 AF140507 
                 −1 
                 CAMKK2 
               
               
                   
                 205114_s_at 
                 NM_002983 
                 −1 
                 CCL3, CCL3L1, 
               
               
                   
                   
                   
                   
                 MGC12815 
               
               
                   
                 202705_at 
                 NM_004701 
                 −1 
                 CCNB2 
               
               
                   
                 205098_at 
                 AI421071 
                 −1 
                 CCR1 
               
               
                   
                 208304_at 
                 NM_001837 
                 −1 
                 CCR3 
               
               
                   
                 207445_s_at 
                 AF145439 
                 −1 
                 CCR9 
               
               
                   
                 210325_at 
                 M28825 
                 −1 
                 CD1A 
               
               
                   
                 207176_s_at 
                 NM_005191 
                 −1 
                 CD80 
               
               
                   
                 211190_x_at 
                 AF054817 
                 −1 
                 CD84 
               
               
                   
                 209287_s_at 
                 AI754416 
                 −1 
                 CDC42EP3 
               
               
                   
                 209057_x_at 
                 AB007892 
                 −1 
                 CDC5L 
               
               
                   
                 220115_s_at 
                 NM_006727 
                 −1 
                 CDH10 
               
               
                   
                 211804_s_at 
                 AB012305 
                 −1 
                 CDK2 
               
               
                   
                 211883_x_at 
                 M76742 
                 −1 
                 CEACAM1 
               
               
                   
                 40020_at 
                 AB011536 
                 −1 
                 CELSR3 
               
               
                   
                 220885_s_at 
                 NM_018451 
                 −1 
                 CENPJ 
               
               
                   
                 202938_x_at 
                 NM_015703 
                 −1 
                 CGI-96, 
               
               
                   
                   
                   
                   
                 dJ222E13.2 
               
               
                   
                 207486_x_at 
                 NM_004067 
                 −1 
                 CHN2 
               
               
                   
                 206635_at 
                 NM_000748 
                 −1 
                 CHRNB2 
               
               
                   
                 215916_at 
                 AL157418 
                 −1 
                 CHRNE 
               
               
                   
                 207075_at 
                 NM_004895 
                 −1 
                 CIAS1 
               
               
                   
                 216016_at 
                 AK027194 
                 −1 
                 CIAS1 
               
               
                   
                 206818_s_at 
                 NM_017649 
                 −1 
                 CNNM2 
               
               
                   
                 209874_x_at 
                 AK023066 
                 −1 
                 CNNM2 
               
               
                   
                 206586_at 
                 NM_001841 
                 −1 
                 CNR2 
               
               
                   
                 211980_at 
                 AI922605 
                 −1 
                 COL4A1 
               
               
                   
                 216898_s_at 
                 U02520 
                 −1 
                 COL4A3 
               
               
                   
                 52651_at 
                 AI806793 
                 −1 
                 COL8A2 
               
               
                   
                 205624_at 
                 NM_001870 
                 −1 
                 CPA3 
               
               
                   
                 222301_at 
                 BF530257 
                 −1 
                 CROC4 
               
               
                   
                 202468_s_at 
                 NM_003798 
                 −1 
                 CTNNAL1 
               
               
                   
                 219080_s_at 
                 NM_019857 
                 −1 
                 CTPS2 
               
               
                   
                 206297_at 
                 NM_007272 
                 −1 
                 CTRC 
               
               
                   
                 205927_s_at 
                 NM_001910 
                 −1 
                 CTSE 
               
               
                   
                 206775_at 
                 NM_001081 
                 −1 
                 CUBN 
               
               
                   
                 204470_at 
                 NM_001511 
                 −1 
                 CXCL1 
               
               
                   
                 209774_x_at 
                 M57731 
                 −1 
                 CXCL2 
               
               
                   
                 207850_at 
                 NM_002090 
                 −1 
                 CXCL3 
               
               
                   
                 206336_at 
                 NM_002993 
                 −1 
                 CXCL6 
               
               
                   
                 205088_at 
                 NM_005491 
                 −1 
                 CXorf6 
               
               
                   
                 214610_at 
                 AV702430 
                 −1 
                 CYP11B1 
               
               
                   
                 217558_at 
                 BE971373 
                 −1 
                 CYP2C9 
               
               
                   
                 213873_at 
                 D29810 
                 −1 
                 D29810 
               
               
                   
                 217025_s_at 
                 AL110225 
                 −1 
                 DBN1 
               
               
                   
                 219490_s_at 
                 NM_022836 
                 −1 
                 DCLRE1B 
               
               
                   
                 205338_s_at 
                 NM_001922 
                 −1 
                 DCT 
               
               
                   
                 213632_at 
                 M94065 
                 −1 
                 DHODH 
               
               
                   
                 219799_s_at 
                 NM_005771 
                 −1 
                 DHRS9 
               
               
                   
                 204494_s_at 
                 AW516789 
                 −1 
                 DKFZP434H132 
               
               
                   
                 214699_x_at 
                 AK024279 
                 −1 
                 DKFZP434J154 
               
               
                   
                 219872_at 
                 NM_016613 
                 −1 
                 DKFZp434L142 
               
               
                   
                 78495_at 
                 R61320 
                 −1 
                 DKFZp762P2111 
               
               
                   
                 208216_at 
                 NM_001934 
                 −1 
                 DLX4 
               
               
                   
                 33768_at 
                 L19267 
                 −1 
                 DMWD 
               
               
                   
                 202866_at 
                 BG283782 
                 −1 
                 DNAJB12 
               
               
                   
                 219746_at 
                 NM_012074 
                 −1 
                 DPF3 
               
               
                   
                 206590_x_at 
                 NM_016574 
                 −1 
                 DRD2 
               
               
                   
                 216938_x_at 
                 S69899 
                 −1 
                 DRD2 
               
               
                   
                 211541_s_at 
                 U52373 
                 −1 
                 DYRK1A 
               
               
                   
                 218660_at 
                 NM_003494 
                 −1 
                 DYSF 
               
               
                   
                 203692_s_at 
                 AI640363 
                 −1 
                 E2F3 
               
               
                   
                 208112_x_at 
                 NM_006795 
                 −1 
                 EHD1 
               
               
                   
                 209038_s_at 
                 AL579035 
                 −1 
                 EHD1 
               
               
                   
                 209039_x_at 
                 AF001434 
                 −1 
                 EHD1 
               
               
                   
                 210376_x_at 
                 M25269 
                 −1 
                 ELK1 
               
               
                   
                 205994_at 
                 NM_001973 
                 −1 
                 ELK4 
               
               
                   
                 396_f_at 
                 X97671 
                 −1 
                 EPOR 
               
               
                   
                 206794_at 
                 NM_005235 
                 −1 
                 ERBB4 
               
               
                   
                 205225_at 
                 NM_000125 
                 −1 
                 ESR1 
               
               
                   
                 206501_x_at 
                 NM_004956 
                 −1 
                 ETV1 
               
               
                   
                 215006_at 
                 AK023816 
                 −1 
                 EZH2 
               
               
                   
                 205189_s_at 
                 NM_000136 
                 −1 
                 FANCC 
               
               
                   
                 204819_at 
                 NM_004463 
                 −1 
                 FGD1 
               
               
                   
                 219901_at 
                 NM_018351 
                 −1 
                 FGD6 
               
               
                   
                 208417_at 
                 NM_020996 
                 −1 
                 FGF6 
               
               
                   
                 219389_at 
                 NM_017982 
                 −1 
                 FLJ10052 
               
               
                   
                 219501_at 
                 NM_017993 
                 −1 
                 FLJ10094 
               
               
                   
                 218815_s_at 
                 NM_018022 
                 −1 
                 FLJ10199 
               
               
                   
                 218814_s_at 
                 NM_018252 
                 −1 
                 FLJ10874 
               
               
                   
                 219450_at 
                 NM_018302 
                 −1 
                 FLJ11017 
               
               
                   
                 220465_at 
                 NM_024988 
                 −1 
                 FLJ12355 
               
               
                   
                 220578_at 
                 NM_025008 
                 −1 
                 FLJ13544 
               
               
                   
                 220149_at 
                 NM_024861 
                 −1 
                 FLJ22671 
               
               
                   
                 221224_s_at 
                 NM_024819 
                 −1 
                 FLJ22955 
               
               
                   
                 215062_at 
                 AL390143 
                 −1 
                 FMNL2 
               
               
                   
                 206263_at 
                 NM_002022 
                 −1 
                 FMO4 
               
               
                   
                 202768_at 
                 NM_006732 
                 −1 
                 FOSB 
               
               
                   
                 219889_at 
                 NM_005479 
                 −1 
                 FRAT1 
               
               
                   
                 211628_x_at 
                 J04755 
                 −1 
                 FTHP1 
               
               
                   
                 215744_at 
                 AW514140 
                 −1 
                 FUS 
               
               
                   
                 209893_s_at 
                 M58596 
                 −1 
                 FUT4 
               
               
                   
                 202488_s_at 
                 NM_005971 
                 −1 
                 FXYD3 
               
               
                   
                 204452_s_at 
                 AF072872 
                 −1 
                 FZD1 
               
               
                   
                 213524_s_at 
                 NM_015714 
                 −1 
                 G0S2 
               
               
                   
                 214772_at 
                 H08993 
                 −1 
                 G2 
               
               
                   
                 208217_at 
                 NM_002043 
                 −1 
                 GABRR2 
               
               
                   
                 207574_s_at 
                 NM_015675 
                 −1 
                 GADD45B 
               
               
                   
                 209305_s_at 
                 AF078077 
                 −1 
                 GADD45B 
               
               
                   
                 207357_s_at 
                 NM_017540 
                 −1 
                 GALNT10 
               
               
                   
                 220929_at 
                 NM_017417 
                 −1 
                 GALNT8 
               
               
                   
                 207954_at 
                 NM_002050 
                 −1 
                 GATA2 
               
               
                   
                 209710_at 
                 AL563460 
                 −1 
                 GATA2 
               
               
                   
                 210358_x_at 
                 BC002557 
                 −1 
                 GATA2 
               
               
                   
                 221314_at 
                 NM_005260 
                 −1 
                 GDF9 
               
               
                   
                 205100_at 
                 NM_005110 
                 −1 
                 GFPT2 
               
               
                   
                 211815_s_at 
                 AF219138 
                 −1 
                 GGA3 
               
               
                   
                 207131_x_at 
                 NM_013430 
                 −1 
                 GGT1 
               
               
                   
                 208284_x_at 
                 NM_013421 
                 −1 
                 GGT1 
               
               
                   
                 209919_x_at 
                 L20490 
                 −1 
                 GGT1 
               
               
                   
                 211417_x_at 
                 L20493 
                 −1 
                 GGT1 
               
               
                   
                 215977_x_at 
                 X68285 
                 −1 
                 GK 
               
               
                   
                 207034_s_at 
                 NM_030379 
                 −1 
                 GLI2 
               
               
                   
                 204762_s_at 
                 NM_020988 
                 −1 
                 GNAO1 
               
               
                   
                 209220_at 
                 L47125 
                 −1 
                 GPC3 
               
               
                   
                 206264_at 
                 L11702 
                 −1 
                 GPLD1 
               
               
                   
                 209168_at 
                 AW148844 
                 −1 
                 GPM6B 
               
               
                   
                 211977_at 
                 AK024651 
                 −1 
                 GPR107 
               
               
                   
                 205220_at 
                 NM_006018 
                 −1 
                 GPR109B 
               
               
                   
                 221394_at 
                 NM_014626 
                 −1 
                 GPR58 
               
               
                   
                 214655_at 
                 U18549 
                 −1 
                 GPR6 
               
               
                   
                 220481_at 
                 NM_006794 
                 −1 
                 GPR75 
               
               
                   
                 205276_s_at 
                 U87964 
                 −1 
                 GTPBP1 
               
               
                   
                 44783_s_at 
                 R61374 
                 −1 
                 HEY1 
               
               
                   
                 210864_x_at 
                 AF144240 
                 −1 
                 HFE 
               
               
                   
                 211328_x_at 
                 AF144244 
                 −1 
                 HFE 
               
               
                   
                 211329_x_at 
                 AF115264 
                 −1 
                 HFE 
               
               
                   
                 211332_x_at 
                 AF144241 
                 −1 
                 HFE 
               
               
                   
                 211863_x_at 
                 AF079408 
                 −1 
                 HFE 
               
               
                   
                 205425_at 
                 NM_005338 
                 −1 
                 HIP1 
               
               
                   
                 205426_s_at 
                 NM_005338 
                 −1 
                 HIP1 
               
               
                   
                 209398_at 
                 BC002649 
                 −1 
                 HIST1H1C 
               
               
                   
                 214290_s_at 
                 AI313324 
                 −1 
                 HIST2H2AA 
               
               
                   
                 218280_x_at 
                 BC001629 
                 −1 
                 HIST2H2AA 
               
               
                   
                 208812_x_at 
                 BC004489 
                 −1 
                 HLA-C, HLA-B 
               
               
                   
                 211911_x_at 
                 L07950 
                 −1 
                 HLA-C, HLA-B 
               
               
                   
                 211654_x_at 
                 M17565 
                 −1 
                 HLA-DQB1 
               
               
                   
                 211528_x_at 
                 M90685 
                 −1 
                 HLA-G 
               
               
                   
                 211529_x_at 
                 M90684 
                 −1 
                 HLA-G 
               
               
                   
                 213844_at 
                 NM_019102 
                 −1 
                 HOXA5 
               
               
                   
                 205601_s_at 
                 NM_002147 
                 −1 
                 HOXB5 
               
               
                   
                 216973_s_at 
                 S49765 
                 −1 
                 HOXB7 
               
               
                   
                 204221_x_at 
                 U16307 
                 −1 
                 HRB2 
               
               
                   
                 214085_x_at 
                 AI912583 
                 −1 
                 HRB2 
               
               
                   
                 209192_x_at 
                 BC000166 
                 −1 
                 HTATIP 
               
               
                   
                 207404_s_at 
                 NM_000865 
                 −1 
                 HTR1E 
               
               
                   
                 36564_at 
                 W27419 
                 −1 
                 IBRDC3 
               
               
                   
                 202637_s_at 
                 AI608725 
                 −1 
                 ICAM1 
               
               
                   
                 202638_s_at 
                 NM_000201 
                 −1 
                 ICAM1 
               
               
                   
                 215485_s_at 
                 AA284705 
                 −1 
                 ICAM1 
               
               
                   
                 203328_x_at 
                 NM_004969 
                 −1 
                 IDE 
               
               
                   
                 202081_at 
                 NM_004907 
                 −1 
                 IER2 
               
               
                   
                 201631_s_at 
                 NM_003897 
                 −1 
                 IER3 
               
               
                   
                 208261_x_at 
                 NM_002171 
                 −1 
                 IFNA10 
               
               
                   
                 214569_at 
                 NM_002169 
                 −1 
                 IFNA5 
               
               
                   
                 208548_at 
                 NM_021002 
                 −1 
                 IFNA6 
               
               
                   
                 208441_at 
                 NM_015883 
                 −1 
                 IGF1R 
               
               
                   
                 202421_at 
                 AB007935 
                 −1 
                 IGSF3 
               
               
                   
                 209032_s_at 
                 AF132811 
                 −1 
                 IGSF4 
               
               
                   
                 207901_at 
                 NM_002187 
                 −1 
                 IL12B 
               
               
                   
                 64440_at 
                 AI560217 
                 −1 
                 IL17RC 
               
               
                   
                 206295_at 
                 NM_001562 
                 −1 
                 IL18 
               
               
                   
                 205067_at 
                 NM_000576 
                 −1 
                 IL1B 
               
               
                   
                 39402_at 
                 M15330 
                 −1 
                 IL1B 
               
               
                   
                 212659_s_at 
                 AW083357 
                 −1 
                 IL1RN 
               
               
                   
                 216243_s_at 
                 BE563442 
                 −1 
                 IL1RN 
               
               
                   
                 220056_at 
                 NM_021258 
                 −1 
                 IL22RA1 
               
               
                   
                 202859_x_at 
                 NM_000584 
                 −1 
                 IL8 
               
               
                   
                 211506_s_at 
                 AF043337 
                 −1 
                 IL8 
               
               
                   
                 202531_at 
                 NM_002198 
                 −1 
                 IRF1 
               
               
                   
                 206766_at 
                 AF112345 
                 −1 
                 ITGA10 
               
               
                   
                 37201_at 
                 D38535 
                 −1 
                 ITIH4 
               
               
                   
                 203682_s_at 
                 NM_002225 
                 −1 
                 IVD 
               
               
                   
                 209098_s_at 
                 U73936 
                 −1 
                 JAG1 
               
               
                   
                 201465_s_at 
                 BC002646 
                 −1 
                 JUN 
               
               
                   
                 211806_s_at 
                 D87291 
                 −1 
                 KCNJ15 
               
               
                   
                 58916_at 
                 AI672101 
                 −1 
                 KCTD14 
               
               
                   
                 211028_s_at 
                 BC006233 
                 −1 
                 KHK 
               
               
                   
                 216251_s_at 
                 BF965437 
                 −1 
                 KIAA0153 
               
               
                   
                 210954_s_at 
                 AF201292 
                 −1 
                 KIAA0669 
               
               
                   
                 31826_at 
                 AB014574 
                 −1 
                 KIAA0674 
               
               
                   
                 212054_x_at 
                 AK026096 
                 −1 
                 KIAA0676 
               
               
                   
                 213358_at 
                 AB018345 
                 −1 
                 KIAA0802 
               
               
                   
                 207705_s_at 
                 NM_025176 
                 −1 
                 KIAA0980 
               
               
                   
                 213478_at 
                 AB028949 
                 −1 
                 KIAA1026 
               
               
                   
                 216294_s_at 
                 AL137254 
                 −1 
                 KIAA1109 
               
               
                   
                 221078_s_at 
                 NM_018084 
                 −1 
                 KIAA1212 
               
               
                   
                 222367_at 
                 AI921841 
                 −1 
                 KIAA1971, 
               
               
                   
                   
                   
                   
                 LOC339005 
               
               
                   
                 205318_at 
                 NM_004984 
                 −1 
                 KIF5A 
               
               
                   
                 207908_at 
                 NM_000423 
                 −1 
                 KRT2A 
               
               
                   
                 215189_at 
                 X99142 
                 −1 
                 KRTHB6 
               
               
                   
                 221717_at 
                 L25664 
                 −1 
                 L25664 
               
               
                   
                 219813_at 
                 NM_004690 
                 −1 
                 LATS1 
               
               
                   
                 204012_s_at 
                 AL529189 
                 −1 
                 LCMT2 
               
               
                   
                 215462_at 
                 AI978990 
                 −1 
                 LOC149478 
               
               
                   
                 51774_s_at 
                 AW014299 
                 −1 
                 LOC222070 
               
               
                   
                 58900_at 
                 AW025284 
                 −1 
                 LOC222070 
               
               
                   
                 217520_x_at 
                 BG396614 
                 −1 
                 LOC283683 
               
               
                   
                 213751_at 
                 AW873594 
                 −1 
                 LOC284352 
               
               
                   
                 214838_at 
                 AL035297 
                 −1 
                 LOC375035 
               
               
                   
                 219071_x_at 
                 NM_016458 
                 −1 
                 LOC51236 
               
               
                   
                 221629_x_at 
                 AF151022 
                 −1 
                 LOC51236 
               
               
                   
                 220244_at 
                 NM_013343 
                 −1 
                 LOH3CR2A 
               
               
                   
                 34697_at 
                 AF074264 
                 −1 
                 LRP6 
               
               
                   
                 219886_at 
                 NM_024548 
                 −1 
                 LRRIQ2 
               
               
                   
                 204682_at 
                 NM_000428 
                 −1 
                 LTBP2 
               
               
                   
                 202018_s_at 
                 NM_002343 
                 −1 
                 LTF 
               
               
                   
                 209480_at 
                 M16276 
                 −1 
                 M16276 
               
               
                   
                 209738_x_at 
                 M31125 
                 −1 
                 M31125 
               
               
                   
                 211241_at 
                 M62895 
                 −1 
                 M62895 
               
               
                   
                 217920_at 
                 BE543064 
                 −1 
                 MAN1A2 
               
               
                   
                 209951_s_at 
                 AF006689 
                 −1 
                 MAP2K7 
               
               
                   
                 214969_at 
                 AF251442 
                 −1 
                 MAP3K9 
               
               
                   
                 204813_at 
                 U34819 
                 −1 
                 MAPK10 
               
               
                   
                 201668_x_at 
                 AW163148 
                 −1 
                 MARCKS 
               
               
                   
                 202485_s_at 
                 NM_003927 
                 −1 
                 MBD2 
               
               
                   
                 200797_s_at 
                 AI275690 
                 −1 
                 MCL1 
               
               
                   
                 202618_s_at 
                 L37298 
                 −1 
                 MECP2 
               
               
                   
                 206028_s_at 
                 NM_006343 
                 −1 
                 MERTK 
               
               
                   
                 211913_s_at 
                 L08961 
                 −1 
                 MERTK 
               
               
                   
                 211599_x_at 
                 U19348 
                 −1 
                 MET 
               
               
                   
                 209758_s_at 
                 U37283 
                 −1 
                 MFAP5 
               
               
                   
                 211717_at 
                 BC005853 
                 −1 
                 MGC15396 
               
               
                   
                 212340_at 
                 BE673723 
                 −1 
                 MGC21416 
               
               
                   
                 217548_at 
                 AA491625 
                 −1 
                 MGC61550 
               
               
                   
                 205905_s_at 
                 NM_000247 
                 −1 
                 MICA, MICB 
               
               
                   
                 208384_s_at 
                 NM_012216 
                 −1 
                 MID2 
               
               
                   
                 212021_s_at 
                 AU132185 
                 −1 
                 MKI67 
               
               
                   
                 218211_s_at 
                 NM_024101 
                 −1 
                 MLPH 
               
               
                   
                 160020_at 
                 Z48481 
                 −1 
                 MMP14 
               
               
                   
                 203936_s_at 
                 NM_004994 
                 −1 
                 MMP9 
               
               
                   
                 203949_at 
                 NM_000250 
                 −1 
                 MPO 
               
               
                   
                 206186_at 
                 NM_001932 
                 −1 
                 MPP3 
               
               
                   
                 210594_x_at 
                 AF239756 
                 −1 
                 MPZL1 
               
               
                   
                 210223_s_at 
                 AF031469 
                 −1 
                 MR1 
               
               
                   
                 210224_at 
                 AF031469 
                 −1 
                 MR1 
               
               
                   
                 210242_x_at 
                 AF249277 
                 −1 
                 MTHFS 
               
               
                   
                 212093_s_at 
                 AI695017 
                 −1 
                 MTUS1 
               
               
                   
                 207847_s_at 
                 NM_002456 
                 −1 
                 MUC1 
               
               
                   
                 212365_at 
                 BF215996 
                 −1 
                 MYO1B 
               
               
                   
                 33197_at 
                 U39226 
                 −1 
                 MYO7A 
               
               
                   
                 210048_at 
                 BC001889 
                 −1 
                 NAPG 
               
               
                   
                 218742_at 
                 NM_022493 
                 −1 
                 NARFL 
               
               
                   
                 217045_x_at 
                 AL136967 
                 −1 
                 NCR2 
               
               
                   
                 202150_s_at 
                 U64317 
                 −1 
                 NEDD9 
               
               
                   
                 203927_at 
                 NM_004556 
                 −1 
                 NFKBIE 
               
               
                   
                 207986_x_at 
                 NM_001915 
                 −1 
                 NM_001915 
               
               
                   
                 208039_at 
                 NM_003048 
                 −1 
                 NM_003048 
               
               
                   
                 208180_s_at 
                 NM_003543 
                 −1 
                 NM_003543 
               
               
                   
                 220814_at 
                 NM_017964 
                 −1 
                 NM_017964 
               
               
                   
                 221105_at 
                 NM_018395 
                 −1 
                 NM_018395 
               
               
                   
                 220872_at 
                 NM_018547 
                 −1 
                 NM_018547 
               
               
                   
                 208540_x_at 
                 NM_021039 
                 −1 
                 NM_021039 
               
               
                   
                 219680_at 
                 NM_024618 
                 −1 
                 NOD9 
               
               
                   
                 39548_at 
                 U77970 
                 −1 
                 NPAS2 
               
               
                   
                 210730_s_at 
                 U36269 
                 −1 
                 NPY2R 
               
               
                   
                 202340_x_at 
                 NM_002135 
                 −1 
                 NR4A1 
               
               
                   
                 204105_s_at 
                 NM_005010 
                 −1 
                 NRCAM 
               
               
                   
                 216959_x_at 
                 U55258 
                 −1 
                 NRCAM 
               
               
                   
                 210022_at 
                 BC004952 
                 −1 
                 NSPC1 
               
               
                   
                 217377_x_at 
                 AF041811 
                 −1 
                 NTRK3 
               
               
                   
                 206553_at 
                 NM_002535 
                 −1 
                 OAS2 
               
               
                   
                 205660_at 
                 NM_003733 
                 −1 
                 OASL 
               
               
                   
                 214485_at 
                 NM_024410 
                 −1 
                 ODF1 
               
               
                   
                 219105_x_at 
                 NM_014321 
                 −1 
                 ORC6L 
               
               
                   
                 205729_at 
                 NM_003999 
                 −1 
                 OSMR 
               
               
                   
                 205815_at 
                 NM_002580 
                 −1 
                 PAP 
               
               
                   
                 213332_at 
                 AL031290 
                 −1 
                 PAPPA2 
               
               
                   
                 204752_x_at 
                 NM_005484 
                 −1 
                 PARP2 
               
               
                   
                 215773_x_at 
                 AJ236912 
                 −1 
                 PARP2 
               
               
                   
                 215418_at 
                 AK022316 
                 −1 
                 PARVA 
               
               
                   
                 121_at 
                 X69699 
                 −1 
                 PAX8 
               
               
                   
                 205656_at 
                 NM_014459 
                 −1 
                 PCDH17 
               
               
                   
                 211066_x_at 
                 BC006439 
                 −1 
                 PDGHGA1-12 
               
               
                   
                   
                   
                   
                 PDGHGB1-7 
               
               
                   
                 206388_at 
                 U36798 
                 −1 
                 PDE3A 
               
               
                   
                 216061_x_at 
                 AK022920 
                 −1 
                 PDGFB 
               
               
                   
                 220236_at 
                 NM_017990 
                 −1 
                 PDPR 
               
               
                   
                 220944_at 
                 NM_020393 
                 −1 
                 PGLYRP4 
               
               
                   
                 215622_x_at 
                 AL137671 
                 −1 
                 PHF7 
               
               
                   
                 209346_s_at 
                 AL561930 
                 −1 
                 PI4KII 
               
               
                   
                 215832_x_at 
                 AV722190 
                 −1 
                 PICALM 
               
               
                   
                 210256_s_at 
                 U78576 
                 −1 
                 PIP5K1A 
               
               
                   
                 204267_x_at 
                 NM_004203 
                 −1 
                 PKMYT1 
               
               
                   
                 202924_s_at 
                 AF006005 
                 −1 
                 PLAGL2 
               
               
                   
                 202925_s_at 
                 NM_002657 
                 −1 
                 PLAGL2 
               
               
                   
                 203471_s_at 
                 NM_002664 
                 −1 
                 PLEK 
               
               
                   
                 39854_r_at 
                 AF055000 
                 −1 
                 PNPLA2 
               
               
                   
                 206654_s_at 
                 NM_006467 
                 −1 
                 POLR3G 
               
               
                   
                 210809_s_at 
                 D13665 
                 −1 
                 POSTN 
               
               
                   
                 207725_at 
                 NM_004575 
                 −1 
                 POU4F2 
               
               
                   
                 216330_s_at 
                 L14482 
                 −1 
                 POU6F1 
               
               
                   
                 212226_s_at 
                 AA628586 
                 −1 
                 PPAP2B 
               
               
                   
                 210235_s_at 
                 U22815 
                 −1 
                 PPFIA1 
               
               
                   
                 201489_at 
                 BC005020 
                 −1 
                 PPIF 
               
               
                   
                 201490_s_at 
                 NM_005729 
                 −1 
                 PPIF 
               
               
                   
                 202014_at 
                 NM_014330 
                 −1 
                 PPP1R15A 
               
               
                   
                 37028_at 
                 U83981 
                 −1 
                 PPP1R15A 
               
               
                   
                 221088_s_at 
                 NM_017650 
                 −1 
                 PPP1R9A 
               
               
                   
                 204506_at 
                 AL544951 
                 −1 
                 PPP3R1 
               
               
                   
                 210499_s_at 
                 AB041834 
                 −1 
                 PQBP1 
               
               
                   
                 209766_at 
                 AF118073 
                 −1 
                 PRDX3 
               
               
                   
                 219732_at 
                 NM_017753 
                 −1 
                 PRG-3 
               
               
                   
                 217269_s_at 
                 AP001672 
                 −1 
                 PRSS7 
               
               
                   
                 210195_s_at 
                 M34715 
                 −1 
                 PSG1 
               
               
                   
                 204897_at 
                 AA897516 
                 −1 
                 PTGER4 
               
               
                   
                 204748_at 
                 NM_000963 
                 −1 
                 PTGS2 
               
               
                   
                 202895_s_at 
                 D86043 
                 −1 
                 PTPNS1 
               
               
                   
                 206157_at 
                 NM_002852 
                 −1 
                 PTX3 
               
               
                   
                 202148_s_at 
                 NM_006907 
                 −1 
                 PYCR1 
               
               
                   
                 211471_s_at 
                 AF133588 
                 −1 
                 RAB36 
               
               
                   
                 37793_r_at 
                 AF034956 
                 −1 
                 RAD51L3 
               
               
                   
                 204916_at 
                 NM_005855 
                 −1 
                 RAMP1 
               
               
                   
                 217020_at 
                 X04014 
                 −1 
                 RARB 
               
               
                   
                 215688_at 
                 AL359931 
                 −1 
                 RASGRF1 
               
               
                   
                 205115_s_at 
                 NM_016196 
                 −1 
                 RBM19 
               
               
                   
                 215761_at 
                 AK000156 
                 −1 
                 RC3 
               
               
                   
                 216153_x_at 
                 AK022897 
                 −1 
                 RECK 
               
               
                   
                 205879_x_at 
                 BC004257 
                 −1 
                 RET 
               
               
                   
                 207936_x_at 
                 NM_006604 
                 −1 
                 RFPL3 
               
               
                   
                 209637_s_at 
                 AF030111 
                 −1 
                 RGS12 
               
               
                   
                 209545_s_at 
                 AF027706 
                 −1 
                 RIPK2 
               
               
                   
                 221287_at 
                 NM_021133 
                 −1 
                 RNASEL 
               
               
                   
                 208270_s_at 
                 NM_020216 
                 −1 
                 RNPEP 
               
               
                   
                 218441_s_at 
                 NM_015540 
                 −1 
                 RPAP1 
               
               
                   
                 213223_at 
                 AK025866 
                 −1 
                 RPL28 
               
               
                   
                 211180_x_at 
                 D89788 
                 −1 
                 RUNX1 
               
               
                   
                 205485_at 
                 NM_000540 
                 −1 
                 RYR1 
               
               
                   
                 217033_x_at 
                 S76475 
                 −1 
                 S76475 
               
               
                   
                 210593_at 
                 M55580 
                 −1 
                 SAT 
               
               
                   
                 217331_at 
                 U63542 
                 −1 
                 SCC-112 
               
               
                   
                 59705_at 
                 AA911739 
                 −1 
                 SCLY 
               
               
                   
                 207413_s_at 
                 NM_000335 
                 −1 
                 SCN5A 
               
               
                   
                 203788_s_at 
                 AI962897 
                 −1 
                 SEMA3C 
               
               
                   
                 35666_at 
                 U38276 
                 −1 
                 SEMA3F 
               
               
                   
                 218122_s_at 
                 NM_021627 
                 −1 
                 SENP2 
               
               
                   
                 209722_s_at 
                 BC002538 
                 −1 
                 SERPINB9 
               
               
                   
                 214197_s_at 
                 AI762193 
                 −1 
                 SETDB1 
               
               
                   
                 33323_r_at 
                 X57348 
                 −1 
                 SFN 
               
               
                   
                 204051_s_at 
                 NM_003014 
                 −1 
                 SFRP4 
               
               
                   
                 201742_x_at 
                 M69040 
                 −1 
                 SFRS1 
               
               
                   
                 37004_at 
                 J02761 
                 −1 
                 SFTPB 
               
               
                   
                 201739_at 
                 NM_005627 
                 −1 
                 SGK 
               
               
                   
                 211211_x_at 
                 AF100542 
                 −1 
                 SH2D1A 
               
               
                   
                 210796_x_at 
                 D86359 
                 −1 
                 SIGLEC6 
               
               
                   
                 207250_at 
                 NM_007374 
                 −1 
                 SIX6 
               
               
                   
                 207095_at 
                 NM_000452 
                 −1 
                 SLC10A2 
               
               
                   
                 217473_x_at 
                 AF229163 
                 −1 
                 SLC11A1 
               
               
                   
                 203125_x_at 
                 AF046997 
                 −1 
                 SLC11A2 
               
               
                   
                 202236_s_at 
                 NM_003051 
                 −1 
                 SLC16A1 
               
               
                   
                 204230_s_at 
                 NM_020309 
                 −1 
                 SLC17A7 
               
               
                   
                 208389_s_at 
                 NM_004171 
                 −1 
                 SLC1A2 
               
               
                   
                 207408_at 
                 NM_004803 
                 −1 
                 SLC22A14 
               
               
                   
                 219344_at 
                 NM_018344 
                 −1 
                 SLC29A3 
               
               
                   
                 216236_s_at 
                 AL110298 
                 −1 
                 SLC2A3 
               
               
                   
                 219991_at 
                 NM_020041 
                 −1 
                 SLC2A9 
               
               
                   
                 210739_x_at 
                 AF069510 
                 −1 
                 SLC4A4 
               
               
                   
                 211123_at 
                 D87920 
                 −1 
                 SLC5A5 
               
               
                   
                 205920_at 
                 NM_003043 
                 −1 
                 SLC6A6 
               
               
                   
                 216092_s_at 
                 AL365347 
                 −1 
                 SLC7A8 
               
               
                   
                 207499_x_at 
                 NM_017979 
                 −1 
                 SMAP-1 
               
               
                   
                 214708_at 
                 BG484314 
                 −1 
                 SNTB1 
               
               
                   
                 215366_at 
                 AL353943 
                 −1 
                 SNX13 
               
               
                   
                 205482_x_at 
                 NM_013306 
                 −1 
                 SNX15 
               
               
                   
                 206663_at 
                 NM_003112 
                 −1 
                 SP4 
               
               
                   
                 205406_s_at 
                 NM_017425 
                 −1 
                 SPA17 
               
               
                   
                 206239_s_at 
                 NM_003122 
                 −1 
                 SPINK1 
               
               
                   
                 216981_x_at 
                 X60502 
                 −1 
                 SPN 
               
               
                   
                 219677_at 
                 NM_025106 
                 −1 
                 SSB1 
               
               
                   
                 203019_x_at 
                 NM_014021 
                 −1 
                 SSX2IP 
               
               
                   
                 214441_at 
                 NM_005819 
                 −1 
                 STX6 
               
               
                   
                 204287_at 
                 NM_004711 
                 −1 
                 SYNGR1 
               
               
                   
                 203999_at 
                 AV731490 
                 −1 
                 SYT1 
               
               
                   
                 212679_at 
                 AK026529 
                 −1 
                 TBL2 
               
               
                   
                 206838_at 
                 NM_005149 
                 −1 
                 TBX19 
               
               
                   
                 211590_x_at 
                 U11271 
                 −1 
                 TBXA2R 
               
               
                   
                 205513_at 
                 NM_001062 
                 −1 
                 TCN1 
               
               
                   
                 221473_x_at 
                 U49188 
                 −1 
                 TDE1 
               
               
                   
                 215902_at 
                 AF009267 
                 −1 
                 TEB4 
               
               
                   
                 204653_at 
                 BF343007 
                 −1 
                 TFAP2A 
               
               
                   
                 205016_at 
                 NM_003236 
                 −1 
                 TGFA 
               
               
                   
                 203834_s_at 
                 NM_006464 
                 −1 
                 TGOLN2 
               
               
                   
                 204064_at 
                 NM_005131 
                 −1 
                 THOC1 
               
               
                   
                 203167_at 
                 NM_003255 
                 −1 
                 TIMP2 
               
               
                   
                 210176_at 
                 AL050262 
                 −1 
                 TLR1 
               
               
                   
                 206271_at 
                 NM_003265 
                 −1 
                 TLR3 
               
               
                   
                 214657_s_at 
                 AU134977 
                 −1 
                 TncRNA 
               
               
                   
                 207113_s_at 
                 NM_000594 
                 −1 
                 TNF 
               
               
                   
                 206025_s_at 
                 AW188198 
                 −1 
                 TNFAIP6 
               
               
                   
                 209294_x_at 
                 BC001281 
                 −1 
                 TNFRSF10B 
               
               
                   
                 210405_x_at 
                 AF153687 
                 −1 
                 TNFRSF10B 
               
               
                   
                 206729_at 
                 NM_001243 
                 −1 
                 TNFRSF8 
               
               
                   
                 211333_s_at 
                 AF288573 
                 −1 
                 TNFSF6 
               
               
                   
                 206990_at 
                 NM_003285 
                 −1 
                 TNR 
               
               
                   
                 202807_s_at 
                 NM_005488 
                 −1 
                 TOM1 
               
               
                   
                 204946_s_at 
                 NM_004618 
                 −1 
                 TOP3A 
               
               
                   
                 215781_s_at 
                 D87012 
                 −1 
                 TOP3B 
               
               
                   
                 211943_x_at 
                 AL565449 
                 −1 
                 TPT1 
               
               
                   
                 36742_at 
                 U34249 
                 −1 
                 TRIM15 
               
               
                   
                 206911_at 
                 NM_005082 
                 −1 
                 TRIM25 
               
               
                   
                 208178_x_at 
                 NM_007118 
                 −1 
                 TRIO 
               
               
                   
                 208349_at 
                 NM_007332 
                 −1 
                 TRPA1 
               
               
                   
                 214205_x_at 
                 AK022131 
                 −1 
                 TXNL2 
               
               
                   
                 210803_at 
                 AF201385 
                 −1 
                 TXNRD2 
               
               
                   
                 215511_at 
                 U19345 
                 −1 
                 U19345 
               
               
                   
                 209947_at 
                 BC003170 
                 −1 
                 UBAP2L 
               
               
                   
                 220422_at 
                 NM_017481 
                 −1 
                 UBQLN3 
               
               
                   
                 221323_at 
                 NM_025218 
                 −1 
                 ULBP1 
               
               
                   
                 205536_at 
                 NM_003371 
                 −1 
                 VAV2 
               
               
                   
                 210513_s_at 
                 AF091352 
                 −1 
                 VEGF 
               
               
                   
                 209822_s_at 
                 L22431 
                 −1 
                 VLDLR 
               
               
                   
                 204787_at 
                 NM_007268 
                 −1 
                 VSIG4 
               
               
                   
                 38964_r_at 
                 U12707 
                 −1 
                 WAS 
               
               
                   
                 221927_s_at 
                 AI923458 
                 −1 
                 WBSCR21 
               
               
                   
                 71933_at 
                 AI218134 
                 −1 
                 WNT6 
               
               
                   
                 210200_at 
                 BC000108 
                 −1 
                 WWP2 
               
               
                   
                 206365_at 
                 NM_002995 
                 −1 
                 XCL1 
               
               
                   
                 216809_at 
                 Z22780 
                 −1 
                 Z22780 
               
               
                   
                 201531_at 
                 NM_003407 
                 −1 
                 ZFP36 
               
               
                   
                 212892_at 
                 AW130128 
                 −1 
                 ZNF282 
               
               
                   
                 216692_at 
                 AL137428 
                 −1 
                 ZNF337 
               
               
                   
                 219089_s_at 
                 NM_024327 
                 −1 
                 ZNF576 
               
               
                   
                 215376_at 
                 AU147830 
                 1 
                 MAMMA1001818 
               
               
                   
                 212829_at 
                 BE878277 
                 1 
                 OVARC1000964 
               
               
                   
                 213686_at 
                 AI186145 
                 1 
                 AI186145 
               
               
                   
                 215287_at 
                 AA975427 
                 1 
                 ELISC-1 
               
               
                   
                 213750_at 
                 AA928506 
                 1 
                 YH77E09 
               
               
                   
                 217529_at 
                 BE547674 
                 1 
                 LOC402578 
               
               
                   
                 215343_at 
                 AF070587 
                 1 
                 0610010D24Rik 
               
               
                   
                 212114_at 
                 BE967207 
                 1 
                 microtubule 
               
               
                   
                   
                   
                   
                 proteins 
               
               
                   
                 212413_at 
                 D50918 
                 1 
                 6-Sep 
               
               
                   
                 212414_s_at 
                 D50918 
                 1 
                 6-Sep 
               
               
                   
                 213970_at 
                 AA744682 
                 1 
                 AA744682 
               
               
                   
                 209307_at 
                 AB014540 
                 1 
                 AB014540 
               
               
                   
                 207819_s_at 
                 NM_000443 
                 1 
                 ABCB4 
               
               
                   
                 209620_s_at 
                 AB005289 
                 1 
                 ABCB7 
               
               
                   
                 214274_s_at 
                 AI860341 
                 1 
                 ACAA1 
               
               
                   
                 205355_at 
                 NM_001609 
                 1 
                 ACADSB 
               
               
                   
                 219962_at 
                 NM_021804 
                 1 
                 ACE2 
               
               
                   
                 201715_s_at 
                 NM_014977 
                 1 
                 ACIN1 
               
               
                   
                 215227_x_at 
                 BG035989 
                 1 
                 ACP1 
               
               
                   
                 202135_s_at 
                 NM_005735 
                 1 
                 ACTR1B 
               
               
                   
                 205260_s_at 
                 NM_001107 
                 1 
                 ACYP1 
               
               
                   
                 206833_s_at 
                 NM_001108 
                 1 
                 ACYP2 
               
               
                   
                 208268_at 
                 NM_021777 
                 1 
                 ADAM28 
               
               
                   
                 209321_s_at 
                 AF033861 
                 1 
                 ADCY3 
               
               
                   
                 208030_s_at 
                 NM_001119 
                 1 
                 ADD1 
               
               
                   
                 201773_at 
                 NM_015339 
                 1 
                 ADNP 
               
               
                   
                 201281_at 
                 NM_007002 
                 1 
                 ADRM1 
               
               
                   
                 202144_s_at 
                 NM_000026 
                 1 
                 ADSL 
               
               
                   
                 217729_s_at 
                 NM_001130 
                 1 
                 AES 
               
               
                   
                 216609_at 
                 AF065241 
                 1 
                 AF065241 
               
               
                   
                 211071_s_at 
                 BC006471 
                 1 
                 AF1Q 
               
               
                   
                 210111_s_at 
                 AF277175 
                 1 
                 AF277175 
               
               
                   
                 204333_s_at 
                 NM_000027 
                 1 
                 AGA 
               
               
                   
                 203566_s_at 
                 NM_000645 
                 1 
                 AGL 
               
               
                   
                 200850_s_at 
                 NM_006621 
                 1 
                 AHCYL1 
               
               
                   
                 202820_at 
                 NM_001621 
                 1 
                 AHR 
               
               
                   
                 212980_at 
                 AL050376 
                 1 
                 AHSA2 
               
               
                   
                 204057_at 
                 AI073984 
                 1 
                 AI073984 
               
               
                   
                 212543_at 
                 U83115 
                 1 
                 AIM1 
               
               
                   
                 214102_at 
                 AK023737 
                 1 
                 AK023737 
               
               
                   
                 201675_at 
                 NM_003488 
                 1 
                 AKAP1 
               
               
                   
                 218580_x_at 
                 NM_017900 
                 1 
                 AKIP 
               
               
                   
                 202139_at 
                 NM_003689 
                 1 
                 AKR7A2 
               
               
                   
                 215307_at 
                 AL109722 
                 1 
                 AL109722 
               
               
                   
                 216421_at 
                 AL121886 
                 1 
                 AL121886 
               
               
                   
                 216490_x_at 
                 AL133267 
                 1 
                 AL133267 
               
               
                   
                 201612_at 
                 NM_000696 
                 1 
                 ALDH9A1 
               
               
                   
                 218203_at 
                 NM_013338 
                 1 
                 ALG5 
               
               
                   
                 203545_at 
                 NM_024079 
                 1 
                 ALG8 
               
               
                   
                 214220_s_at 
                 AW003635 
                 1 
                 ALMS1 
               
               
                   
                 204976_s_at 
                 AK023637 
                 1 
                 AMMECR1 
               
               
                   
                 208722_s_at 
                 BC001081 
                 1 
                 ANAPC5 
               
               
                   
                 218769_s_at 
                 NM_023039 
                 1 
                 ANKRA2 
               
               
                   
                 218093_s_at 
                 NM_017664 
                 1 
                 ANKRD10 
               
               
                   
                 212211_at 
                 AI986295 
                 1 
                 ANKRD17 
               
               
                   
                 202442_at 
                 NM_001284 
                 1 
                 AP3S1 
               
               
                   
                 210278_s_at 
                 AF155159 
                 1 
                 AP4S1 
               
               
                   
                 213115_at 
                 AL031177 
                 1 
                 APG4A 
               
               
                   
                 202512_s_at 
                 AK001899 
                 1 
                 APG5L 
               
               
                   
                 202630_at 
                 AA046411 
                 1 
                 APPBP2 
               
               
                   
                 213892_s_at 
                 AA927724 
                 1 
                 APRT 
               
               
                   
                 201526_at 
                 NM_001662 
                 1 
                 ARF5 
               
               
                   
                 218870_at 
                 NM_018460 
                 1 
                 ARHGAP15 
               
               
                   
                 213039_at 
                 AB011093 
                 1 
                 ARHGEF18 
               
               
                   
                 218964_at 
                 NM_006465 
                 1 
                 ARID3B 
               
               
                   
                 221230_s_at 
                 NM_016374 
                 1 
                 ARID4B 
               
               
                   
                 201229_s_at 
                 BC000422 
                 1 
                 ARIH2 
               
               
                   
                 201230_s_at 
                 NM_006321 
                 1 
                 ARIH2 
               
               
                   
                 218868_at 
                 NM_020445 
                 1 
                 ARP3BETA 
               
               
                   
                 215457_at 
                 AF070647 
                 1 
                 ARPC1A 
               
               
                   
                 207988_s_at 
                 NM_005731 
                 1 
                 ARPC2 
               
               
                   
                 213513_x_at 
                 BG034239 
                 1 
                 ARPC2 
               
               
                   
                 215684_s_at 
                 AL096741 
                 1 
                 ASCC2 
               
               
                   
                 212672_at 
                 U82828 
                 1 
                 ATM 
               
               
                   
                 211755_s_at 
                 BC005960 
                 1 
                 ATP5F1 
               
               
                   
                 207508_at 
                 NM_001689 
                 1 
                 ATP5G3 
               
               
                   
                 209492_x_at 
                 BC003679 
                 1 
                 ATP5I 
               
               
                   
                 202325_s_at 
                 NM_001685 
                 1 
                 ATP5J 
               
               
                   
                 200818_at 
                 NM_001697 
                 1 
                 ATP5O 
               
               
                   
                 214934_at 
                 AW411030 
                 1 
                 ATP9B 
               
               
                   
                 209903_s_at 
                 U49844 
                 1 
                 ATR 
               
               
                   
                 208833_s_at 
                 AF119662 
                 1 
                 ATXN10 
               
               
                   
                 214691_x_at 
                 AU121431 
                 1 
                 AU121431 
               
               
                   
                 222297_x_at 
                 AV738806 
                 1 
                 AV738806 
               
               
                   
                 221589_s_at 
                 AW612403 
                 1 
                 AW612403 
               
               
                   
                 202387_at 
                 NM_004323 
                 1 
                 BAG1 
               
               
                   
                 219667_s_at 
                 NM_017935 
                 1 
                 BANK1 
               
               
                   
                 202326_at 
                 NM_006709 
                 1 
                 BAT8 
               
               
                   
                 211833_s_at 
                 U19599 
                 1 
                 BAX 
               
               
                   
                 200837_at 
                 NM_005745 
                 1 
                 BCAP31 
               
               
                   
                 210347_s_at 
                 AF080216 
                 1 
                 BCL11A 
               
               
                   
                 219497_s_at 
                 NM_018014 
                 1 
                 BCL11A 
               
               
                   
                 202315_s_at 
                 NM_004327 
                 1 
                 BCR 
               
               
                   
                 213282_at 
                 BE501952 
                 1 
                 BE501952 
               
               
                   
                 213637_at 
                 BE503392 
                 1 
                 BE503392 
               
               
                   
                 215440_s_at 
                 AL523320 
                 1 
                 BEXL1 
               
               
                   
                 222026_at 
                 BF437591 
                 1 
                 BF437591 
               
               
                   
                 221847_at 
                 BF665706 
                 1 
                 BF665706 
               
               
                   
                 206255_at 
                 NM_001715 
                 1 
                 BLK 
               
               
                   
                 207655_s_at 
                 NM_013314 
                 1 
                 BLNK 
               
               
                   
                 201849_at 
                 NM_004052 
                 1 
                 BNIP3 
               
               
                   
                 212563_at 
                 BG491842 
                 1 
                 BOP1 
               
               
                   
                 203502_at 
                 NM_001724 
                 1 
                 BPGM 
               
               
                   
                 213473_at 
                 AL042733 
                 1 
                 BRAP 
               
               
                   
                 204531_s_at 
                 NM_007295 
                 1 
                 BRCA1 
               
               
                   
                 220059_at 
                 NM_012108 
                 1 
                 BRDG1 
               
               
                   
                 219177_at 
                 NM_018321 
                 1 
                 BRIX 
               
               
                   
                 201458_s_at 
                 NM_004725 
                 1 
                 BUB3 
               
               
                   
                 209974_s_at 
                 AF047473 
                 1 
                 BUB3 
               
               
                   
                 202808_at 
                 AK000161 
                 1 
                 C10orf26 
               
               
                   
                 55662_at 
                 H27225 
                 1 
                 C10orf76 
               
               
                   
                 219067_s_at 
                 NM_017615 
                 1 
                 C10orf86 
               
               
                   
                 218213_s_at 
                 NM_014206 
                 1 
                 C11orf10 
               
               
                   
                 52164_at 
                 AA065185 
                 1 
                 C11orf24 
               
               
                   
                 218220_at 
                 NM_021640 
                 1 
                 C12orf10 
               
               
                   
                 44790_s_at 
                 AI129310 
                 1 
                 C13orf18 
               
               
                   
                 218940_at 
                 NM_024558 
                 1 
                 C14orf138 
               
               
                   
                 217768_at 
                 NM_016039 
                 1 
                 C14orf166 
               
               
                   
                 221932_s_at 
                 AA133341 
                 1 
                 C14orf87 
               
               
                   
                 201685_s_at 
                 NM_014828 
                 1 
                 C14orf92 
               
               
                   
                 208837_at 
                 BC000027 
                 1 
                 C15orf22 
               
               
                   
                 219439_at 
                 NM_020156 
                 1 
                 C1GALT1 
               
               
                   
                 212164_at 
                 AL522296 
                 1 
                 C1orf37 
               
               
                   
                 203960_s_at 
                 NM_016126 
                 1 
                 C1orf41 
               
               
                   
                 214214_s_at 
                 AU151801 
                 1 
                 C1QBP 
               
               
                   
                 209422_at 
                 AY027523 
                 1 
                 C20orf104 
               
               
                   
                 218448_at 
                 NM_017896 
                 1 
                 C20orf11 
               
               
                   
                 219443_at 
                 NM_017714 
                 1 
                 C20orf13 
               
               
                   
                 217737_x_at 
                 NM_016407 
                 1 
                 C20orf43 
               
               
                   
                 217851_s_at 
                 NM_016045 
                 1 
                 C20orf45 
               
               
                   
                 218859_s_at 
                 NM_016649 
                 1 
                 C20orf6 
               
               
                   
                 202217_at 
                 NM_004649 
                 1 
                 C21orf33 
               
               
                   
                 218123_at 
                 NM_017835 
                 1 
                 C21orf59 
               
               
                   
                 221211_s_at 
                 NM_020152 
                 1 
                 C21orf7 
               
               
                   
                 218037_at 
                 NM_024293 
                 1 
                 C2orf17 
               
               
                   
                 221984_s_at 
                 AL040896 
                 1 
                 C2orf17 
               
               
                   
                 219137_s_at 
                 NM_020194 
                 1 
                 C2orf33 
               
               
                   
                 218518_at 
                 NM_016603 
                 1 
                 C5orf5 
               
               
                   
                 212176_at 
                 AA902326 
                 1 
                 C6orf111 
               
               
                   
                 208809_s_at 
                 AL136632 
                 1 
                 C6orf62 
               
               
                   
                 203259_s_at 
                 BC001671 
                 1 
                 C6orf74 
               
               
                   
                 41047_at 
                 AI885170 
                 1 
                 C9orf16 
               
               
                   
                 218992_at 
                 NM_018465 
                 1 
                 C9orf46 
               
               
                   
                 211984_at 
                 AI653730 
                 1 
                 CALM1 
               
               
                   
                 200622_x_at 
                 AV685208 
                 1 
                 CALM3 
               
               
                   
                 203538_at 
                 NM_001745 
                 1 
                 CAMLG 
               
               
                   
                 218929_at 
                 NM_017632 
                 1 
                 CARF 
               
               
                   
                 202402_s_at 
                 NM_001751 
                 1 
                 CARS 
               
               
                   
                 213373_s_at 
                 BF439983 
                 1 
                 CASP8 
               
               
                   
                 200037_s_at 
                 NM_016587 
                 1 
                 CBX3 
               
               
                   
                 219174_at 
                 NM_025103 
                 1 
                 CCDC2 
               
               
                   
                 219470_x_at 
                 NM_019084 
                 1 
                 CCNJ 
               
               
                   
                 204645_at 
                 NM_001241 
                 1 
                 CCNT2 
               
               
                   
                 200910_at 
                 NM_005998 
                 1 
                 CCT3 
               
               
                   
                 200812_at 
                 NM_006429 
                 1 
                 CCT7 
               
               
                   
                 206398_s_at 
                 NM_001770 
                 1 
                 CD19 
               
               
                   
                 209583_s_at 
                 AF063591 
                 1 
                 CD200 
               
               
                   
                 204581_at 
                 NM_001771 
                 1 
                 CD22 
               
               
                   
                 38521_at 
                 X59350 
                 1 
                 CD22 
               
               
                   
                 208650_s_at 
                 BG327863 
                 1 
                 CD24 
               
               
                   
                 208651_x_at 
                 BG327863 
                 1 
                 CD24 
               
               
                   
                 209771_x_at 
                 AA761181 
                 1 
                 CD24 
               
               
                   
                 216379_x_at 
                 AK000168 
                 1 
                 CD24 
               
               
                   
                 203593_at 
                 NM_012120 
                 1 
                 CD2AP 
               
               
                   
                 213856_at 
                 BG230614 
                 1 
                 CD47 
               
               
                   
                 200984_s_at 
                 X16447 
                 1 
                 CD59 
               
               
                   
                 200985_s_at 
                 NM_000611 
                 1 
                 CD59 
               
               
                   
                 215925_s_at 
                 AF283777 
                 1 
                 CD72 
               
               
                   
                 205049_s_at 
                 NM_001783 
                 1 
                 CD79A 
               
               
                   
                 205297_s_at 
                 NM_000626 
                 1 
                 CD79B 
               
               
                   
                 206761_at 
                 NM_005816 
                 1 
                 CD96 
               
               
                   
                 205288_at 
                 NM_003672 
                 1 
                 CDC14A 
               
               
                   
                 203468_at 
                 NM_003674 
                 1 
                 CDK10 
               
               
                   
                 212899_at 
                 AB028951 
                 1 
                 CDK11 
               
               
                   
                 204252_at 
                 M68520 
                 1 
                 CDK2 
               
               
                   
                 34210_at 
                 N90866 
                 1 
                 CDW52 
               
               
                   
                 218592_s_at 
                 NM_017829 
                 1 
                 CECR5 
               
               
                   
                 205642_at 
                 NM_007018 
                 1 
                 CEP1 
               
               
                   
                 209194_at 
                 BC005334 
                 1 
                 CETN2 
               
               
                   
                 215318_at 
                 AL049782 
                 1 
                 CG012 
               
               
                   
                 218628_at 
                 NM_016053 
                 1 
                 CGI-116 
               
               
                   
                 219030_at 
                 NM_016058 
                 1 
                 CGI-121 
               
               
                   
                 218102_at 
                 NM_015954 
                 1 
                 CGI-26 
               
               
                   
                 219590_x_at 
                 NM_015958 
                 1 
                 CGI-30 
               
               
                   
                 203721_s_at 
                 NM_016001 
                 1 
                 CGI-48 
               
               
                   
                 201569_s_at 
                 NM_015380 
                 1 
                 CGI-51 
               
               
                   
                 218642_s_at 
                 NM_024300 
                 1 
                 CHCHD7 
               
               
                   
                 208968_s_at 
                 BC002568 
                 1 
                 CIAPIN1 
               
               
                   
                 200999_s_at 
                 NM_006825 
                 1 
                 CKAP4 
               
               
                   
                 201897_s_at 
                 BC001425 
                 1 
                 CKS1B 
               
               
                   
                 212752_at 
                 AA176798 
                 1 
                 CLASP1 
               
               
                   
                 219859_at 
                 NM_014358 
                 1 
                 CLECSF9 
               
               
                   
                 204085_s_at 
                 NM_006493 
                 1 
                 CLN5 
               
               
                   
                 204577_s_at 
                 NM_024793 
                 1 
                 CLUAP1 
               
               
                   
                 218111_s_at 
                 NM_018686 
                 1 
                 CMAS 
               
               
                   
                 208912_s_at 
                 BC001362 
                 1 
                 CNP 
               
               
                   
                 203642_s_at 
                 NM_014900 
                 1 
                 COBLL1 
               
               
                   
                 203073_at 
                 NM_007357 
                 1 
                 COG2 
               
               
                   
                 213243_at 
                 AI052003 
                 1 
                 COH1 
               
               
                   
                 201652_at 
                 NM_006837 
                 1 
                 COPS5 
               
               
                   
                 218328_at 
                 NM_016035 
                 1 
                 COQ4 
               
               
                   
                 200086_s_at 
                 AA854966 
                 1 
                 COX4I1 
               
               
                   
                 203663_s_at 
                 NM_004255 
                 1 
                 COX5A 
               
               
                   
                 211025_x_at 
                 BC006229 
                 1 
                 COX5B 
               
               
                   
                 201754_at 
                 NM_004374 
                 1 
                 COX6C 
               
               
                   
                 213846_at 
                 AA382702 
                 1 
                 COX7C 
               
               
                   
                 218142_s_at 
                 NM_016302 
                 1 
                 CRBN 
               
               
                   
                 208670_s_at 
                 AF109873 
                 1 
                 CRI1 
               
               
                   
                 205081_at 
                 NM_001311 
                 1 
                 CRIP1 
               
               
                   
                 204349_at 
                 BC005250 
                 1 
                 CRSP9 
               
               
                   
                 220753_s_at 
                 NM_015974 
                 1 
                 CRYL1 
               
               
                   
                 221139_s_at 
                 NM_015989 
                 1 
                 CSAD 
               
               
                   
                 201160_s_at 
                 AL556190 
                 1 
                 CSDA 
               
               
                   
                 212073_at 
                 AI631874 
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                 NM_001896 
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                 AU145232 
                 1 
                 CUL3 
               
               
                   
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                 NM_015960 
                 1 
                 CUTC 
               
               
                   
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                 AK026546 
                 1 
                 CXCL5 
               
               
                   
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                 M22976 
                 1 
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                 1 
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                 BF516433 
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                 1 
                 CYP2R1 
               
               
                   
                 216060_s_at 
                 AK021890 
                 1 
                 DAAM1 
               
               
                   
                 201624_at 
                 NM_001349 
                 1 
                 DARS 
               
               
                   
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                 NM_018959 
                 1 
                 DAZAP1 
               
               
                   
                 202428_x_at 
                 NM_020548 
                 1 
                 DBI 
               
               
                   
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                 1 
                 DDOST 
               
               
                   
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                 DDX28 
               
               
                   
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                 1 
                 DDX50 
               
               
                   
                 220482_s_at 
                 NM_012139 
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                 DGUOK 
               
               
                   
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                 NM_004735 
                   
                 DHRS3 
               
               
                   
                 202031_s_at 
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                 1 
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                 AW299245 
                 1 
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                 AI927701 
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                 1 
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                 221596_s_at 
                 AL136619 
                 1 
                 DKFZP564O0523 
               
               
                   
                 202537_s_at 
                 NM_014043 
                 1 
                 DKFZP564O123 
               
               
                   
                 210006_at 
                 BC002571 
                 1 
                 DKFZP564O243 
               
               
                   
                 213149_at 
                 AW299740 
                 1 
                 DLAT 
               
               
                   
                 205677_s_at 
                 NM_005887 
                 1 
                 DLEU1 
               
               
                   
                 208810_at 
                 AF080569 
                 1 
                 DNAJB6 
               
               
                   
                 212467_at 
                 AB014578 
                 1 
                 DNAJC13 
               
               
                   
                 213088_s_at 
                 BE551340 
                 1 
                 DNAJC9 
               
               
                   
                 213092_x_at 
                 AW241779 
                 1 
                 DNAJC9 
               
               
                   
                 217917_s_at 
                 NM_014183 
                 1 
                 DNCL2A 
               
               
                   
                 212538_at 
                 AL576253 
                 1 
                 DOCK9 
               
               
                   
                 221677_s_at 
                 AF232674 
                 1 
                 DONSON 
               
               
                   
                 219452_at 
                 NM_022355 
                 1 
                 DPEP2 
               
               
                   
                 219373_at 
                 NM_018973 
                 1 
                 DPM3 
               
               
                   
                 208370_s_at 
                 NM_004414 
                 1 
                 DSCR1 
               
               
                   
                 218576_s_at 
                 NM_007240 
                 1 
                 DUSP12 
               
               
                   
                 208956_x_at 
                 AB049113 
                 1 
                 DUT 
               
               
                   
                 209033_s_at 
                 D86550 
                 1 
                 DYRK1A 
               
               
                   
                 207232_s_at 
                 NM_014648 
                 1 
                 DZIP3 
               
               
                   
                 221586_s_at 
                 U15642 
                 1 
                 E2F5 
               
               
                   
                 220942_x_at 
                 NM_014367 
                 1 
                 E2IG5 
               
               
                   
                 219787_s_at 
                 NM_018098 
                 1 
                 ECT2 
               
               
                   
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                 BF515424 
                 1 
                 EDD 
               
               
                   
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                 1 
                 EDF1 
               
               
                   
                 209059_s_at 
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                 1 
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                 AI346431 
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                 EG1 
               
               
                   
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                 1 
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                 AW083133 
                 1 
                 eIF3k 
               
               
                   
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                 U36764 
                 1 
                 EIF3S2 
               
               
                   
                 201437_s_at 
                 NM_001968 
                 1 
                 EIF4E 
               
               
                   
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                 R39094 
                 1 
                 EIF4EBP3, 
               
               
                   
                   
                   
                   
                 MASK-BP3 
               
               
                   
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                 D45421 
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                 ENPP2 
               
               
                   
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                 202909_at 
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                 EPM2AIP1 
               
               
                   
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                 ERH 
               
               
                   
                 218100_s_at 
                 NM_018010 
                 1 
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                 NM_001985 
                 1 
                 ETFB 
               
               
                   
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                 NM_004453 
                 1 
                 ETFDH 
               
               
                   
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                 NM_016337 
                 1 
                 EVL 
               
               
                   
                 215136_s_at 
                 AL050353 
                 1 
                 EXOSC8 
               
               
                   
                 32259_at 
                 AB002386 
                 1 
                 EZH1 
               
               
                   
                 202862_at 
                 NM_000137 
                 1 
                 FAH 
               
               
                   
                 218504_at 
                 NM_016044 
                 1 
                 FAHD2A 
               
               
                   
                 220643_s_at 
                 NM_018147 
                 1 
                 FAIM 
               
               
                   
                 209405_s_at 
                 BC002934 
                 1 
                 FAM3A 
               
               
                   
                 38043_at 
                 X55448 
                 1 
                 FAM3A 
               
               
                   
                 201889_at 
                 NM_014888 
                 1 
                 FAM3C 
               
               
                   
                 204283_at 
                 NM_006567 
                 1 
                 FARS1 
               
               
                   
                 211623_s_at 
                 M30448 
                 1 
                 FBL 
               
               
                   
                 222119_s_at 
                 AL117620 
                 1 
                 FBXO11 
               
               
                   
                 212231_at 
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                 FBXO21 
               
               
                   
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                 1 
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                 206759_at 
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                 1 
                 FCER2 
               
               
                   
                 210889_s_at 
                 M31933 
                 1 
                 FCGR2B 
               
               
                   
                 203620_s_at 
                 NM_014824 
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                 AU152635 
                 1 
                 FECH 
               
               
                   
                 201540_at 
                 NM_001449 
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                 FHL1 
               
               
                   
                 214505_s_at 
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                 1 
                 FHL1 
               
               
                   
                 221007_s_at 
                 NM_030917 
                 1 
                 FIPIL1 
               
               
                   
                 219117_s_at 
                 NM_016594 
                 1 
                 FKBP11 
               
               
                   
                 219118_at 
                 NM_016594 
                 1 
                 FKBP11 
               
               
                   
                 218003_s_at 
                 M90820 
                 1 
                 FKBP3 
               
               
                   
                 218349_s_at 
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                 FLJ10036 
               
               
                   
                 205510_s_at 
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                 N64802 
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                 FLJ11806 
               
               
                   
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                 NM_024664 
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                 FLJ11838 
               
               
                   
                 219022_at 
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                 1 
                 FLJ12448 
               
               
                   
                 217866_at 
                 NM_024811 
                 1 
                 FLJ12529 
               
               
                   
                 46142_at 
                 AI003763 
                 1 
                 FLJ12681 
               
               
                   
                 218179_s_at 
                 NM_021942 
                 1 
                 FLJ12716 
               
               
                   
                 220199_s_at 
                 NM_022831 
                 1 
                 FLJ12806 
               
               
                   
                 44065_at 
                 AI937468 
                 1 
                 FLJ14827 
               
               
                   
                 219798_s_at 
                 NM_019606 
                 1 
                 FLJ20257 
               
               
                   
                 209672_s_at 
                 AL136892 
                 1 
                 FLJ20323 
               
               
                   
                 206583_at 
                 NM_017776 
                 1 
                 FLJ20344 
               
               
                   
                 221222_s_at 
                 NM_017860 
                 1 
                 FLJ20519 
               
               
                   
                 219751_at 
                 NM_024860 
                 1 
                 FLJ21148 
               
               
                   
                 218531_at 
                 NM_025124 
                 1 
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                 NM_022762 
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                 FLJ22555 
               
               
                   
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                 NM_024943 
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                 FLJ23235 
               
               
                   
                 64432_at 
                 W05463 
                 1 
                 FLJ39616 
               
               
                   
                 218053_at 
                 NM_017892 
                 1 
                 FNBP3 
               
               
                   
                 202304_at 
                 NM_014923 
                 1 
                 FNDC3 
               
               
                   
                 203064_s_at 
                 NM_004514 
                 1 
                 FOXK2 
               
               
                   
                 209702_at 
                 U79260 
                 1 
                 FTO 
               
               
                   
                 205324_s_at 
                 NM_012280 
                 1 
                 FTSJ1 
               
               
                   
                 218356_at 
                 NM_013393 
                 1 
                 FTSJ2 
               
               
                   
                 212847_at 
                 AL036840 
                 1 
                 FUBP1 
               
               
                   
                 214093_s_at 
                 AA156865 
                 1 
                 FUBP1 
               
               
                   
                 202231_at 
                 NM_006360 
                 1 
                 GA17 
               
               
                   
                 204618_s_at 
                 NM_005254 
                 1 
                 GABPB2 
               
               
                   
                 219815_at 
                 NM_024637 
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                 GAL3ST4 
               
               
                   
                 213049_at 
                 BG436400 
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                 GARNL1 
               
               
                   
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                 GC20 
               
               
                   
                 212139_at 
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                 1 
                 GLO1 
               
               
                   
                 209883_at 
                 AF288389 
                 1 
                 GLT25D2 
               
               
                   
                 218913_s_at 
                 NM_016573 
                 1 
                 GMIP 
               
               
                   
                 214157_at 
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                 1 
                 GNAS 
               
               
                   
                 202382_s_at 
                 NM_005471 
                 1 
                 GNPDA1 
               
               
                   
                 202106_at 
                 NM_005895 
                 1 
                 GOLGA3 
               
               
                   
                 201056_at 
                 N53479 
                 1 
                 GOLGB1 
               
               
                   
                 208843_s_at 
                 BC001408 
                 1 
                 GORASP2 
               
               
                   
                 209470_s_at 
                 D49958 
                 1 
                 GPM6A 
               
               
                   
                 204793_at 
                 NM_014710 
                 1 
                 GPRASP1 
               
               
                   
                 201106_at 
                 NM_002085 
                 1 
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                 204396_s_at 
                 NM_005308 
                 1 
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                 201520_s_at 
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                 1 
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                 215438_x_at 
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                 1 
                 GSPT1 
               
               
                   
                 201912_s_at 
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                 1 
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                 202680_at 
                 NM_002095 
                 1 
                 GTF2E2 
               
               
                   
                 213357_at 
                 AV701318 
                 1 
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                 201338_x_at 
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                 1 
                 GTF3A 
               
               
                   
                 215091_s_at 
                 BE542815 
                 1 
                 GTF3A 
               
               
                   
                 218343_s_at 
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                 1 
                 GTF3C3 
               
               
                   
                 200075_s_at 
                 BC006249 
                 1 
                 GUK1 
               
               
                   
                 220936_s_at 
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                 200853_at 
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                 200080_s_at 
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                 AI972144 
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                 HADHA 
               
               
                   
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                 NM_002109 
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                 HARS 
               
               
                   
                 203138_at 
                 NM_003642 
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                 209116_x_at 
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                 1 
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                 215985_at 
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                 1 
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                 NM_005335 
                 1 
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                 218620_s_at 
                 NM_016173 
                 1 
                 HEMK1 
               
               
                   
                 200093_s_at 
                 N32864 
                 1 
                 HINT1 
               
               
                   
                 218946_at 
                 NM_015700 
                 1 
                 HIRIP5 
               
               
                   
                 205671_s_at 
                 NM_002120 
                 1 
                 HLA-DOB 
               
               
                   
                 203290_at 
                 NM_002122 
                 1 
                 HLA-DQA1 
               
               
                   
                 200679_x_at 
                 NM_002128 
                 1 
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                 208808_s_at 
                 BC000903 
                 1 
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                 1 
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                 200944_s_at 
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                 1 
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                 D89678 
                 1 
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                 1 
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                 AK024911 
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                 BC001449 
                 1 
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                 HNRPUL1 
               
               
                   
                 203202_at 
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                 1 
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                 203203_s_at 
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                 NM_001535 
                 1 
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                 AL570294 
                 1 
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                 NM_014168 
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                 HSPC133 
               
               
                   
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                 HTATSF1 
               
               
                   
                 212493_s_at 
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                 IARS 
               
               
                   
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                 X17115 
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                 AU153366 
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                 IKBKB 
               
               
                   
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                 NM_000206 
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                 IL2RG 
               
               
                   
                 221548_s_at 
                 AY024365 
                 1 
                 ILKAP 
               
               
                   
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                 BE747342 
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                 IMP4 
               
               
                   
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                 NM_001564 
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                 ING1L 
               
               
                   
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                 NM_018442 
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                 IQWD1 
               
               
                   
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                 212287_at 
                 BF382924 
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                 JJAZ1 
               
               
                   
                 210878_s_at 
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                 JMJD1B 
               
               
                   
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                 AI341811 
                 1 
                 JMJD2C 
               
               
                   
                 200048_s_at 
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                 JTB 
               
               
                   
                 218570_at 
                 NM_018095 
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                 KBTBD4 
               
               
                   
                 45653_at 
                 AW026481 
                 1 
                 KCTD13 
               
               
                   
                 218823_s_at 
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                 KCTD9 
               
               
                   
                 212733_at 
                 AI798908 
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                 KIAA0226 
               
               
                   
                 212735_at 
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                 KIAA0265 
               
               
                   
                 212855_at 
                 D87466 
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                 212621_at 
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                 212485_at 
                 AU146596 
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                 212675_s_at 
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                 1 
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                 1 
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                 NM_004986 
                 1 
                 KTN1 
               
               
                   
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                 TXNDC7 
               
               
                   
                 214709_s_at 
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                 KTN1, 
               
               
                   
                   
                   
                   
                 TXNDC7 
               
               
                   
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                 1 
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                 1 
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                 1 
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                 1 
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                 1 
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                 1 
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                 1 
                 LOC283824 
               
               
                   
                 219043_s_at 
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                 1 
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                 PDCL3 
               
               
                   
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                 1 
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                 50374_at 
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                 1 
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                 1 
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                 1 
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                 1 
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                 1 
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                 1 
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                 1 
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                 1 
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                 1 
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                 OFD1 
               
               
                   
                 219073_s_at 
                 NM_017784 
                 1 
                 OSBPL10 
               
               
                   
                 208717_at 
                 BC001669 
                 1 
                 OXA1L 
               
               
                   
                 206637_at 
                 NM_014879 
                 1 
                 P2RY14 
               
               
                   
                 218131_s_at 
                 AK024670 
                 1 
                 p66alpha 
               
               
                   
                 201545_s_at 
                 NM_004643 
                 1 
                 PABPN1 
               
               
                   
                 200816_s_at 
                 NM_000430 
                 1 
                 PAFAH1B1 
               
               
                   
                 208051_s_at 
                 NM_006451 
                 1 
                 PAIP1 
               
               
                   
                 209064_x_at 
                 BF248165 
                 1 
                 PAIP1 
               
               
                   
                 210466_s_at 
                 BC002488 
                 1 
                 PAI-RBP1 
               
               
                   
                 202759_s_at 
                 BE879367 
                 1 
                 PALM2-AKAP2 
               
               
                   
                 204715_at 
                 NM_015368 
                 1 
                 PANX1 
               
               
                   
                 212718_at 
                 BF797555 
                 1 
                 PAPOLA 
               
               
                   
                 200006_at 
                 NM_007262 
                 1 
                 PARK7 
               
               
                   
                 203905_at 
                 NM_002582 
                 1 
                 PARN 
               
               
                   
                 219033_at 
                 NM_024615 
                 1 
                 PARP8 
               
               
                   
                 213534_s_at 
                 D50925 
                 1 
                 PASK 
               
               
                   
                 204004_at 
                 AI336206 
                 1 
                 PAWR 
               
               
                   
                 205353_s_at 
                 NM_002567 
                 1 
                 PBP 
               
               
                   
                 210825_s_at 
                 AF130103 
                 1 
                 PBP 
               
               
                   
                 211941_s_at 
                 BE969671 
                 1 
                 PBP 
               
               
                   
                 214177_s_at 
                 AI935162 
                 1 
                 PBXIP1 
               
               
                   
                 212694_s_at 
                 NM_000532 
                 1 
                 PCCB 
               
               
                   
                 219737_s_at 
                 NM_020403 
                 1 
                 PCDH9 
               
               
                   
                 203378_at 
                 AB020631 
                 1 
                 PCF11 
               
               
                   
                 218260_at 
                 NM_024050 
                 1 
                 PCIA1 
               
               
                   
                 202174_s_at 
                 NM_006197 
                 1 
                 PCM1 
               
               
                   
                 218014_at 
                 NM_024844 
                 1 
                 PCNT1 
               
               
                   
                 205559_s_at 
                 NM_006200 
                 1 
                 PCSK5 
               
               
                   
                 212422_at 
                 AL547263 
                 1 
                 PDCD11 
               
               
                   
                 204025_s_at 
                 NM_002598 
                 1 
                 PDCD2 
               
               
                   
                 213581_at 
                 BF446180 
                 1 
                 PDCD2 
               
               
                   
                 203415_at 
                 NM_013232 
                 1 
                 PDCD6 
               
               
                   
                 204491_at 
                 R40917 
                 1 
                 PDE4D 
               
               
                   
                 214129_at 
                 AI821791 
                 1 
                 PDE4DIP 
               
               
                   
                 219575_s_at 
                 NM_022341 
                 1 
                 PDF, COG8 
               
               
                   
                 221811_at 
                 BF033007 
                 1 
                 PERLD1 
               
               
                   
                 219180_s_at 
                 AI817074 
                 1 
                 PEX26 
               
               
                   
                 205361_s_at 
                 AI718295 
                 1 
                 PFDN4 
               
               
                   
                 210908_s_at 
                 AB055804 
                 1 
                 PFDN5 
               
               
                   
                 204604_at 
                 NM_012395 
                 1 
                 PFTK1 
               
               
                   
                 222125_s_at 
                 BC000580 
                 1 
                 PH-4 
               
               
                   
                 212542_s_at 
                 BF224151 
                 1 
                 PHIP 
               
               
                   
                 202738_s_at 
                 BG149218 
                 1 
                 PHKB 
               
               
                   
                 202739_s_at 
                 NM_000293 
                 1 
                 PHKB 
               
               
                   
                 203335_at 
                 NM_006214 
                 1 
                 PHYH 
               
               
                   
                 209625_at 
                 BC004100 
                 1 
                 PIGH 
               
               
                   
                 209998_at 
                 BC001030 
                 1 
                 PIGO 
               
               
                   
                 202927_at 
                 NM_006221 
                 1 
                 PIN1 
               
               
                   
                 205632_s_at 
                 NM_003558 
                 1 
                 PIP5K1B 
               
               
                   
                 213111_at 
                 AB023198 
                 1 
                 PIP5K3 
               
               
                   
                 218667_at 
                 NM_022368 
                 1 
                 PJA1 
               
               
                   
                 54051_at 
                 H59033 
                 1 
                 PKNOX1 
               
               
                   
                 205372_at 
                 NM_002655 
                 1 
                 PLAG1 
               
               
                   
                 213309_at 
                 AL117515 
                 1 
                 PLCL2 
               
               
                   
                 219024_at 
                 NM_021622 
                 1 
                 PLEKHA1 
               
               
                   
                 201682_at 
                 NM_004279 
                 1 
                 PMPCB 
               
               
                   
                 213677_s_at 
                 BG434893 
                 1 
                 PMS1 
               
               
                   
                 218961_s_at 
                 NM_007254 
                 1 
                 PNKP 
               
               
                   
                 205901_at 
                 NM_006228 
                 1 
                 PNOC 
               
               
                   
                 209740_s_at 
                 U03886 
                 1 
                 PNPLA4 
               
               
                   
                 201115_at 
                 NM_006230 
                 1 
                 POLD2 
               
               
                   
                 217806_s_at 
                 NM_015584 
                 1 
                 POLDIP2 
               
               
                   
                 203366_at 
                 NM_002693 
                 1 
                 POLG 
               
               
                   
                 212955_s_at 
                 AL037557 
                 1 
                 POLR2I 
               
               
                   
                 218016_s_at 
                 NM_018119 
                 1 
                 POLR3E 
               
               
                   
                 203782_s_at 
                 NM_005035 
                 1 
                 POLRMT 
               
               
                   
                 213360_s_at 
                 AA514622 
                 1 
                 POM121, 
               
               
                   
                   
                   
                   
                 LOC340318 
               
               
                   
                 204839_at 
                 NM_015918 
                 1 
                 POP5 
               
               
                   
                 209482_at 
                 BC001430 
                 1 
                 POP7 
               
               
                   
                 205267_at 
                 NM_006235 
                 1 
                 POU2AF1 
               
               
                   
                 205661_s_at 
                 NM_025207 
                 1 
                 PP591 
               
               
                   
                 202494_at 
                 NM_006112 
                 1 
                 PP1E 
               
               
                   
                 212750_at 
                 AB020630 
                 1 
                 PPP1R16B 
               
               
                   
                 41577_at 
                 AB020630 
                 1 
                 PPP1R16B 
               
               
                   
                 202165_at 
                 BF966540 
                 1 
                 PPP1R2 
               
               
                   
                 207830_s_at 
                 NM_002713 
                 1 
                 PPP1R8 
               
               
                   
                 221772_s_at 
                 AI459157 
                 1 
                 PPP2R2D 
               
               
                   
                 201877_s_at 
                 NM_002719 
                 1 
                 PPP2R5C 
               
               
                   
                 202432_at 
                 NM_021132 
                 1 
                 PPP3CB 
               
               
                   
                 202741_at 
                 AA130247 
                 1 
                 PRKACB 
               
               
                   
                 207957_s_at 
                 NM_002738 
                 1 
                 PRKCB1 
               
               
                   
                 209685_s_at 
                 M13975 
                 1 
                 PRKCB1 
               
               
                   
                 208694_at 
                 U47077 
                 1 
                 PRKDC 
               
               
                   
                 220553_s_at 
                 NM_018333 
                 1 
                 PRPF39 
               
               
                   
                 209161_at 
                 AI184802 
                 1 
                 PRPF4 
               
               
                   
                 202127_at 
                 AB011108 
                 1 
                 PRPF4B 
               
               
                   
                 209440_at 
                 BC001605 
                 1 
                 PRPS1 
               
               
                   
                 203401_at 
                 NM_002765 
                 1 
                 PRPS2 
               
               
                   
                 202529_at 
                 NM_002766 
                 1 
                 PRPSAP1 
               
               
                   
                 203089_s_at 
                 NM_013247 
                 1 
                 PRSS25 
               
               
                   
                 209337_at 
                 AF063020 
                 1 
                 PSIP1 
               
               
                   
                 202244_at 
                 NM_002796 
                 1 
                 PSMB4 
               
               
                   
                 209503_s_at 
                 AF035309 
                 1 
                 PSMC5 
               
               
                   
                 212296_at 
                 NM_005805 
                 1 
                 PSMD14 
               
               
                   
                 200830_at 
                 NM_002808 
                 1 
                 PSMD2 
               
               
                   
                 212219_at 
                 D38521 
                 1 
                 PSME4 
               
               
                   
                 218371_s_at 
                 AA969958 
                 1 
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                 NM_013341 
                 1 
                 PTD004 
               
               
                   
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                 NM_014754 
                 1 
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                 AL121905 
                 1 
                 PTPRA 
               
               
                   
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                 NM_014676 
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                 PUM1 
               
               
                   
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                 D87078 
                 1 
                 PUM2 
               
               
                   
                 201608_s_at 
                 NM_007062 
                 1 
                 PWP1 
               
               
                   
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                 NM_014402 
                 1 
                 QP-C 
               
               
                   
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                 NM_015361 
                 1 
                 R3HDM 
               
               
                   
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                 RAB31 
               
               
                   
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                 AF255648 
                 1 
                 RAB3-GAP150 
               
               
                   
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                 NM_003929 
                 1 
                 RAB7L1 
               
               
                   
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                 AI922519 
                 1 
                 RABGAP1 
               
               
                   
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                 U49245 
                 1 
                 RABGGTB 
               
               
                   
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                 NM_007081 
                 1 
                 RABL2A, 
               
               
                   
                   
                   
                   
                 RABL2B 
               
               
                   
                 207405_s_at 
                 NM_002873 
                 1 
                 RAD17 
               
               
                   
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                 NM_014636 
                 1 
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                 220338_at 
                 NM_018037 
                 1 
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                 1 
                 RANBP10 
               
               
                   
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                 BC000947 
                 1 
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                 1 
                 RANBP9 
               
               
                   
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                 NM_014185 
                 1 
                 RANGNRF 
               
               
                   
                 209444_at 
                 BC001851 
                 1 
                 RAP1GDS1 
               
               
                   
                 205169_at 
                 NM_005057 
                 1 
                 RBBP5 
               
               
                   
                 212781_at 
                 AK026954 
                 1 
                 RBBP6 
               
               
                   
                 201092_at 
                 NM_002893 
                 1 
                 RBBP7 
               
               
                   
                 57540_at 
                 AI823980 
                 1 
                 RBKS 
               
               
                   
                 204178_s_at 
                 NM_006328 
                 1 
                 RBM14 
               
               
                   
                 218117_at 
                 NM_014248 
                 1 
                 RBX1 
               
               
                   
                 201486_at 
                 NM_002902 
                 1 
                 RCN2 
               
               
                   
                 203898_at 
                 AU154853 
                 1 
                 RCP9 
               
               
                   
                 222203_s_at 
                 AK023625 
                 1 
                 RDH14 
               
               
                   
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                 AF309553 
                 1 
                 REC14 
               
               
                   
                 210568_s_at 
                 BC001052 
                 1 
                 RECQL 
               
               
                   
                 219041_s_at 
                 NM_014374 
                 1 
                 REPIN1 
               
               
                   
                 202296_s_at 
                 NM_007033 
                 1 
                 RER1 
               
               
                   
                 218428_s_at 
                 NM_016316 
                 1 
                 REV1L 
               
               
                   
                 208070_s_at 
                 NM_002912 
                 1 
                 REV3L 
               
               
                   
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                 NM_005798 
                 1 
                 RFP2 
               
               
                   
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                 NM_014899 
                 1 
                 RHOBTB3 
               
               
                   
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                 1 
                 RIOK3 
               
               
                   
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                 1 
                 RIPK5 
               
               
                   
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                 1 
                 RNASE4 
               
               
                   
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                 BG534527 
                 1 
                 RNASEH1 
               
               
                   
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                 NM_003799 
                 1 
                 RNMT 
               
               
                   
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                 AK024976 
                 1 
                 RNP24 
               
               
                   
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                 AL109955 
                 1 
                 RNPC1 
               
               
                   
                 218462_at 
                 NM_025065 
                 1 
                 RPF1 
               
               
                   
                 222229_x_at 
                 AL121871 
                 1 
                 RPL26 
               
               
                   
                 218830_at 
                 NM_016093 
                 1 
                 RPL26L1 
               
               
                   
                 221593_s_at 
                 BC001663 
                 1 
                 RPL31 
               
               
                   
                 213687_s_at 
                 BE968801 
                 1 
                 RPL35A 
               
               
                   
                 210034_s_at 
                 AA582460 
                 1 
                 RPL5 
               
               
                   
                 211542_x_at 
                 BC004334 
                 1 
                 RPS10 
               
               
                   
                 200095_x_at 
                 AA320764 
                 1 
                 RPS10 
               
               
                   
                 213890_x_at 
                 AI200589 
                 1 
                 RPS16 
               
               
                   
                 200949_x_at 
                 NM_001023 
                 1 
                 RPS20 
               
               
                   
                 200091_s_at 
                 AA888388 
                 1 
                 RPS25 
               
               
                   
                 200741_s_at 
                 NM_001030 
                 1 
                 RPS27 
               
               
                   
                 200017_at 
                 NM_002954 
                 1 
                 RPS27A 
               
               
                   
                 218007_s_at 
                 BC003667 
                 1 
                 RPS27L 
               
               
                   
                 208904_s_at 
                 BF431363 
                 1 
                 RPS28 
               
               
                   
                 204635_at 
                 NM_004755 
                 1 
                 RPS6KA5 
               
               
                   
                 205540_s_at 
                 NM_016656 
                 1 
                 RRAGB 
               
               
                   
                 218088_s_at 
                 AK023373 
                 1 
                 RRAGC 
               
               
                   
                 208456_s_at 
                 NM_012250 
                 1 
                 RRAS2 
               
               
                   
                 203704_s_at 
                 AW118862 
                 1 
                 RREB1 
               
               
                   
                 201975_at 
                 NM_002956 
                 1 
                 RSN 
               
               
                   
                 212319_at 
                 AB007857 
                 1 
                 RUTBC1 
               
               
                   
                 201459_at 
                 NM_006666 
                 1 
                 RUVBL2 
               
               
                   
                 219598_s_at 
                 NM_016104 
                 1 
                 RWDD1 
               
               
                   
                 205087_at 
                 NM_015485 
                 1 
                 RWDD3 
               
               
                   
                 212438_at 
                 BG252325 
                 1 
                 RY1 
               
               
                   
                 213262_at 
                 AI932370 
                 1 
                 SACS 
               
               
                   
                 203280_at 
                 NM_014649 
                 1 
                 SAFB2 
               
               
                   
                 209486_at 
                 BC004546 
                 1 
                 SAS10 
               
               
                   
                 218276_s_at 
                 AI679398 
                 1 
                 SAV1 
               
               
                   
                 213244_at 
                 AI207792 
                 1 
                 SCAMP4 
               
               
                   
                 205790_at 
                 NM_003726 
                 1 
                 SCAP1 
               
               
                   
                 212140_at 
                 AB014548 
                 1 
                 SCC-112 
               
               
                   
                 202541_at 
                 BF589679 
                 1 
                 SCYE1 
               
               
                   
                 218607_s_at 
                 NM_018115 
                 1 
                 SDAD1 
               
               
                   
                 218649_x_at 
                 NM_004713 
                 1 
                 SDCCAG1 
               
               
                   
                 218427_at 
                 NM_006643 
                 1 
                 SDCCAG3 
               
               
                   
                 200945_s_at 
                 NM_014933 
                 1 
                 SEC31L1 
               
               
                   
                 219349_s_at 
                 NM_018303 
                 1 
                 SEC5L1 
               
               
                   
                 201916_s_at 
                 NM_007214 
                 1 
                 SEC63 
               
               
                   
                 212630_at 
                 AF055006 
                 1 
                 SEC6L1 
               
               
                   
                 218265_at 
                 NM_024077 
                 1 
                 SECISBP2 
               
               
                   
                 219351_at 
                 NM_014563 
                 1 
                 SEDL 
               
               
                   
                 221931_s_at 
                 AV701173 
                 1 
                 SEH1L 
               
               
                   
                 204563_at 
                 NM_000655 
                 1 
                 SELL 
               
               
                   
                 201194_at 
                 NM_003009 
                 1 
                 SEPW1 
               
               
                   
                 209723_at 
                 BC002538 
                 1 
                 SERPINB9 
               
               
                   
                 205352_at 
                 NM_005025 
                 1 
                 SERPINI1 
               
               
                   
                 205933_at 
                 NM_015559 
                 1 
                 SETBP1 
               
               
                   
                 216457_s_at 
                 AK026080 
                 1 
                 SF3A1 
               
               
                   
                 203818_s_at 
                 NM_006802 
                 1 
                 SF3A3 
               
               
                   
                 200685_at 
                 AU146237 
                 1 
                 SFRS11 
               
               
                   
                 200686_s_at 
                 NM_004768 
                 1 
                 SFRS11 
               
               
                   
                 214853_s_at 
                 AI091079 
                 1 
                 SHC1 
               
               
                   
                 205063_at 
                 NM_003616 
                 1 
                 SIP1 
               
               
                   
                 213600_at 
                 AA425633 
                 1 
                 SIPA1L3 
               
               
                   
                 219185_at 
                 NM_012241 
                 1 
                 SIRT5 
               
               
                   
                 203489_at 
                 NM_006427 
                 1 
                 SIVA 
               
               
                   
                 200718_s_at 
                 AA927664 
                 1 
                 SKP1A 
               
               
                   
                 207974_s_at 
                 NM_006930 
                 1 
                 SKP1A 
               
               
                   
                 205234_at 
                 NM_004696 
                 1 
                 SLC16A4 
               
               
                   
                 203775_at 
                 NM_014251 
                 1 
                 SLC25A13 
               
               
                   
                 218989_x_at 
                 NM_022902 
                 1 
                 SLC30A5 
               
               
                   
                 213082_s_at 
                 AJ005866 
                 1 
                 SLC35D2 
               
               
                   
                 218928_s_at 
                 NM_018964 
                 1 
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                 202111_at 
                 NM_003040 
                 1 
                 SLC4A2 
               
               
                   
                 209884_s_at 
                 AF047033 
                 1 
                 SLC4A7 
               
               
                   
                 215043_s_at 
                 X83301 
                 1 
                 SMA3, SMA5 
               
               
                   
                 201784_s_at 
                 NM_014267 
                 1 
                 SMAP 
               
               
                   
                 206544_x_at 
                 NM_003070 
                 1 
                 SMARCA2 
               
               
                   
                 218452_at 
                 NM_014140 
                 1 
                 SMARCAL1 
               
               
                   
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                 AF113019 
                 1 
                 SMARCD2 
               
               
                   
                 218781_at 
                 NM_024624 
                 1 
                 SMC6L1 
               
               
                   
                 205596_s_at 
                 AY014180 
                 1 
                 SMURF2 
               
               
                   
                 202690_s_at 
                 BC001721 
                 1 
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                 NM_003095 
                 1 
                 SNRPF 
               
               
                   
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                 L13857 
                 1 
                 SOS1 
               
               
                   
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                 NM_030764 
                 1 
                 SPAP1 
               
               
                   
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                 NM_014041 
                 1 
                 SPC12 
               
               
                   
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                 AK002207 
                 1 
                 SPG20 
               
               
                   
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                 NM_003121 
                 1 
                 SPIB 
               
               
                   
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                 1 
                 SPIN2 
               
               
                   
                 212071_s_at 
                 BE968833 
                 1 
                 SPTBN1 
               
               
                   
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                 NM_013349 
                 1 
                 SPUF 
               
               
                   
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                 1 
                 SQLE 
               
               
                   
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                 1 
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                 201247_at 
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                 1 
                 SREBF2 
               
               
                   
                 205335_s_at 
                 NM_003135 
                 1 
                 SRP19 
               
               
                   
                 201273_s_at 
                 NM_003133 
                 1 
                 SRP9 
               
               
                   
                 202200_s_at 
                 NM_003137 
                 1 
                 SRPK1 
               
               
                   
                 218140_x_at 
                 NM_021203 
                 1 
                 SRPRB 
               
               
                   
                 201138_s_at 
                 NM_003142 
                 1 
                 SSB 
               
               
                   
                 201139_s_at 
                 NM_003142 
                 1 
                 SSB 
               
               
                   
                 202591_s_at 
                 NM_003143 
                 1 
                 SSBP1 
               
               
                   
                 208666_s_at 
                 BE866412 
                 1 
                 ST13 
               
               
                   
                 208667_s_at 
                 U17714 
                 1 
                 ST13 
               
               
                   
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                 1 
                 STAU 
               
               
                   
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                 1 
                 STK24 
               
               
                   
                 217934_x_at 
                 NM_005861 
                 1 
                 STUB1 
               
               
                   
                 203310_at 
                 NM_007269 
                 1 
                 STXBP3 
               
               
                   
                 221213_s_at 
                 NM_017661 
                 1 
                 SUHW4 
               
               
                   
                 202829_s_at 
                 NM_005638 
                 1 
                 SYBL1 
               
               
                   
                 219156_at 
                 NM_018373 
                 1 
                 SYNJ2BP 
               
               
                   
                 200055_at 
                 NM_006284 
                 1 
                 TAF10 
               
               
                   
                 206613_s_at 
                 NM_005681 
                 1 
                 TAF1A 
               
               
                   
                 221508_at 
                 BC002756 
                 1 
                 TAOK3 
               
               
                   
                 201263_at 
                 NM_003191 
                 1 
                 TARS 
               
               
                   
                 209154_at 
                 AF234997 
                 1 
                 TAX1BP3 
               
               
                   
                 218466_at 
                 NM_024682 
                 1 
                 TBC1D17 
               
               
                   
                 203667_at 
                 NM_004607 
                 1 
                 TBCA 
               
               
                   
                 203715_at 
                 NM_003193 
                 1 
                 TBCE 
               
               
                   
                 213400_s_at 
                 AV753028 
                 1 
                 TBL1X 
               
               
                   
                 209820_s_at 
                 BC002361 
                 1 
                 TBL3 
               
               
                   
                 216241_s_at 
                 X57198 
                 1 
                 TCEA1 
               
               
                   
                 202371_at 
                 NM_024863 
                 1 
                 TCEAL4 
               
               
                   
                 209153_s_at 
                 M31523 
                 1 
                 TCF3 
               
               
                   
                 222146_s_at 
                 AK026674 
                 1 
                 TCF4 
               
               
                   
                 222010_at 
                 BF224073 
                 1 
                 TCP1 
               
               
                   
                 222011_s_at 
                 BF224073 
                 1 
                 TCP1 
               
               
                   
                 203054_s_at 
                 NM_022171 
                 1 
                 TCTA 
               
               
                   
                 203448_s_at 
                 AI347136 
                 1 
                 TERF1 
               
               
                   
                 212330_at 
                 R60866 
                 1 
                 TFDP1 
               
               
                   
                 218996_at 
                 NM_013342 
                 1 
                 TFPT 
               
               
                   
                 214977_at 
                 AK023852 
                 1 
                 TG 
               
               
                   
                 212910_at 
                 W19873 
                 1 
                 THAP11 
               
               
                   
                 213043_s_at 
                 AI023317 
                 1 
                 THRAP4 
               
               
                   
                 43544_at 
                 AA314406 
                 1 
                 THRAP5 
               
               
                   
                 218188_s_at 
                 NM_012458 
                 1 
                 TIMM13 
               
               
                   
                 203222_s_at 
                 NM_005077 
                 1 
                 TLE1 
               
               
                   
                 211077_s_at 
                 Z25421 
                 1 
                 TLK1 
               
               
                   
                 212997_s_at 
                 AU151689 
                 1 
                 TLK2 
               
               
                   
                 208942_s_at 
                 U93239 
                 1 
                 TLOC1 
               
               
                   
                 217979_at 
                 NM_014399 
                 1 
                 TM4SF13 
               
               
                   
                 208184_s_at 
                 NM_003274 
                 1 
                 TMEM1 
               
               
                   
                 209412_at 
                 U61500 
                 1 
                 TMEM1 
               
               
                   
                 218477_at 
                 NM_014051 
                 1 
                 TMEM14A 
               
               
                   
                 221452_s_at 
                 NM_030969 
                 1 
                 TMEM14B 
               
               
                   
                 202857_at 
                 NM_014255 
                 1 
                 TMEM4 
               
               
                   
                 209796_s_at 
                 BC001027 
                 1 
                 TMEM4 
               
               
                   
                 215346_at 
                 BF664114 
                 1 
                 TNFRSF5 
               
               
                   
                 206150_at 
                 NM_001242 
                 1 
                 TNFRSF7 
               
               
                   
                 48531_at 
                 AA522816 
                 1 
                 TNIP2 
               
               
                   
                 202561_at 
                 AF070613 
                 1 
                 TNKS 
               
               
                   
                 210886_x_at 
                 AB007457 
                 1 
                 TP53AP1 
               
               
                   
                 220865_s_at 
                 NM_014317 
                 1 
                 TPRT 
               
               
                   
                 213334_x_at 
                 BE676218 
                 1 
                 TREX2 
               
               
                   
                 210846_x_at 
                 AF220130 
                 1 
                 TRIM14 
               
               
                   
                 212544_at 
                 AI131008 
                 1 
                 TRIP3 
               
               
                   
                 202642_s_at 
                 NM_003496 
                 1 
                 TRRAP 
               
               
                   
                 215735_s_at 
                 AC005600 
                 1 
                 TSC2 
               
               
                   
                 214606_at 
                 BF129969 
                 1 
                 TSPAN-2 
               
               
                   
                 212928_at 
                 AL050331 
                 1 
                 TSPYL4 
               
               
                   
                 217968_at 
                 NM_003310 
                 1 
                 TSSC1 
               
               
                   
                 36936_at 
                 U58766 
                 1 
                 TSTA3 
               
               
                   
                 201434_at 
                 NM_003314 
                 1 
                 TTC1 
               
               
                   
                 217964_at 
                 NM_017775 
                 1 
                 TTC19 
               
               
                   
                 210645_s_at 
                 D83077 
                 1 
                 TTC3 
               
               
                   
                 213174_at 
                 BE675549 
                 1 
                 TTC9 
               
               
                   
                 202266_at 
                 NM_016614 
                 1 
                 TTRAP 
               
               
                   
                 209077_at 
                 AL022313 
                 1 
                 TXN2 
               
               
                   
                 201010_s_at 
                 NM_006472 
                 1 
                 TXNIP 
               
               
                   
                 37577_at 
                 U79256 
                 1 
                 U79256 
               
               
                   
                 202151_s_at 
                 NM_016172 
                 1 
                 UBADC1 
               
               
                   
                 209115_at 
                 AL117566 
                 1 
                 UBE1C 
               
               
                   
                 201343_at 
                 BE621259 
                 1 
                 UBE2D2 
               
               
                   
                 201344_at 
                 BF196642 
                 1 
                 UBE2D2 
               
               
                   
                 210024_s_at 
                 AB017644 
                 1 
                 UBE2E3 
               
               
                   
                 201002_s_at 
                 NM_003349 
                 1 
                 UBE2V1, Kua- 
               
               
                   
                   
                   
                   
                 UEV 
               
               
                   
                 218082_s_at 
                 NM_014517 
                 1 
                 UBP1 
               
               
                   
                 205687_at 
                 NM_019116 
                 1 
                 UBPH 
               
               
                   
                 212008_at 
                 N29889 
                 1 
                 UBXD2 
               
               
                   
                 218533_s_at 
                 NM_017859 
                 1 
                 UCKL1 
               
               
                   
                 209103_s_at 
                 BC001049 
                 1 
                 UFD1L 
               
               
                   
                 212074_at 
                 BE972774 
                 1 
                 UNC84A 
               
               
                   
                 206958_s_at 
                 AF318575 
                 1 
                 UPF3A 
               
               
                   
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                 AF318575 
                 1 
                 UPF3A 
               
               
                   
                 214323_s_at 
                 N36842 
                 1 
                 UPF3A 
               
               
                   
                 202090_s_at 
                 NM_006830 
                 1 
                 UQCR 
               
               
                   
                 208909_at 
                 BC000649 
                 1 
                 UQCRFS1 
               
               
                   
                 208970_s_at 
                 M14016 
                 1 
                 UROD 
               
               
                   
                 203031_s_at 
                 NM_000375 
                 1 
                 UROS 
               
               
                   
                 200083_at 
                 AA621731 
                 1 
                 USP22 
               
               
                   
                 212388_at 
                 AB028980 
                 1 
                 USP24 
               
               
                   
                 220079_s_at 
                 NM_018391 
                 1 
                 USP48 
               
               
                   
                 2031171_s_at 
                 NM_014871 
                 1 
                 USP52 
               
               
                   
                 202745_at 
                 NM_005154 
                 1 
                 USP8 
               
               
                   
                 221514_at 
                 BC001149 
                 1 
                 UTP14A 
               
               
                   
                 218495_at 
                 NM_004182 
                 1 
                 UXT 
               
               
                   
                 207100_s_at 
                 NM_016830 
                 1 
                 VAMP1 
               
               
                   
                 214792_x_at 
                 AI955119 
                 1 
                 VAMP2 
               
               
                   
                 202550_s_at 
                 AF160212 
                 1 
                 VAPB 
               
               
                   
                 212038_s_at 
                 AL515918 
                 1 
                 VDAC1 
               
               
                   
                 203683_s_at 
                 NM_003377 
                 1 
                 VEGFB 
               
               
                   
                 208623_s_at 
                 J05021 
                 1 
                 VIL2 
               
               
                   
                 209950_s_at 
                 BC004300 
                 1 
                 VILL 
               
               
                   
                 205844_at 
                 NM_004666 
                 1 
                 VNN1 
               
               
                   
                 204376_at 
                 NM_014703 
                 1 
                 VprBP 
               
               
                   
                 220068_at 
                 NM_013378 
                 1 
                 VPREB3 
               
               
                   
                 212326_at 
                 AB007922 
                 1 
                 VPS13D 
               
               
                   
                 218022_at 
                 NM_016440 
                 1 
                 VRK3 
               
               
                   
                 221998_s_at 
                 BF062886 
                 1 
                 VRK3 
               
               
                   
                 213048_s_at 
                 W26593 
                 1 
                 W26593 
               
               
                   
                 213598_at 
                 W87688 
                 1 
                 W87688 
               
               
                   
                 221725_at 
                 AI962978 
                 1 
                 WASF2 
               
               
                   
                 200609_s_at 
                 NM_017491 
                 1 
                 WDR1 
               
               
                   
                 209216_at 
                 BC000464 
                 1 
                 WDR45 
               
               
                   
                 212533_at 
                 X62048 
                 1 
                 WEE1 
               
               
                   
                 203112_s_at 
                 NM_005663 
                 1 
                 WHSC2 
               
               
                   
                 34225_at 
                 AF101434 
                 1 
                 WHSC2 
               
               
                   
                 205672_at 
                 NM_000380 
                 1 
                 XPA 
               
               
                   
                 212160_at 
                 AI984005 
                 1 
                 XPOT 
               
               
                   
                 213077_at 
                 AL049305 
                 1 
                 YTHDC2 
               
               
                   
                 219186_at 
                 NM_020224 
                 1 
                 ZBTB7 
               
               
                   
                 217594_at 
                 R25849 
                 1 
                 ZCCHC11 
               
               
                   
                 212655_at 
                 AB011151 
                 1 
                 ZCCHC14 
               
               
                   
                 212860_at 
                 BG168720 
                 1 
                 ZDHHC18 
               
               
                   
                 220261_s_at 
                 NM_018106 
                 1 
                 ZDHHC4 
               
               
                   
                 220206_at 
                 NM_024772 
                 1 
                 ZMYM1 
               
               
                   
                 207605_x_at 
                 NM_024498 
                 1 
                 ZNF117 
               
               
                   
                 37254_at 
                 U09366 
                 1 
                 ZNF133 
               
               
                   
                 209565_at 
                 BC000832 
                 1 
                 ZNF183 
               
               
                   
                 202778_s_at 
                 NM_003453 
                 1 
                 ZNF198 
               
               
                   
                 214823_at 
                 AF033199 
                 1 
                 ZNF204 
               
               
                   
                 219925_at 
                 NM_007167 
                 1 
                 ZNF258 
               
               
                   
                 211009_s_at 
                 AF159567 
                 1 
                 ZNF271 
               
               
                   
                 216399_s_at 
                 AK025663 
                 1 
                 ZNF291 
               
               
                   
                 211678_s_at 
                 AF090934 
                 1 
                 ZNF313 
               
               
                   
                 209538_at 
                 U69645 
                 1 
                 ZNF32 
               
               
                   
                 218079_s_at 
                 NM_024835 
                 1 
                 ZNF403 
               
               
                   
                 221626_at 
                 AL136548 
                 1 
                 ZNF506 
               
               
                   
                 204291_at 
                 NM_014803 
                 1 
                 ZNF518 
               
               
                   
                 221645_s_at 
                 M27877 
                 1 
                 ZNF83 
               
               
                   
                   
               
               
                   
                 Table 2: Genetic markers which are differentially expressed between probable multiple sclerosis which further converted to the diagnosis of definite MS during a two-years follow up and healthy controls are provided (the Probeset ID of the Affymetrix Gene Chip), along with the corresponding GenBank accession number (GenBank Acc. No.), the gene symbol and the direction of change in gene expression (“1”- upregulation; “−1” - downregulation). Note that the p values of the TNOM, Info and t-Test statistical tests all passed the 95% confidence level. 
               
            
           
         
       
     
     Sustained probable MS: Analysis of the signature of non-convertors—Analyzing of probable MS patients that did not convert to definite MS during the 2-year follow-up period as compared to healthy controls identified a specific gene expression signature of 503 most informative genes that is characteristic to these patients (Table 3, hereinbelow). 
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 Differentially expressed markers between probable multiple 
               
               
                 sclerosis subjects which did not convert to the diagnosis of 
               
               
                 definite multiple sclerosis (non-convertors) and healthy controls 
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                 GenBank 
                   
                 Gene 
               
               
                   
                 Probeset 
                 Acc. No. 
                 Dir 
                 Symbol 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 212126_at 
                   
                 −1 
                 BG391282 
               
               
                   
                 213002_at 
                 AA770596 
                 −1 
                 AA770596 
               
               
                   
                 207593_at 
                 NM_022169 
                 −1 
                 ABCG4 
               
               
                   
                 219935_at 
                 NM_007038 
                 −1 
                 ADAMTS5 
               
               
                   
                 216678_at 
                 AK000773 
                 −1 
                 AK000773 
               
               
                   
                 222252_x_at 
                 AK023354 
                 −1 
                 AK023354 
               
               
                   
                 216746_at 
                 AK024606 
                 −1 
                 AK024606 
               
               
                   
                 216774_at 
                 AK025325 
                 −1 
                 AK025325 
               
               
                   
                 216336_x_at 
                 AL031602 
                 −1 
                 AL031602 
               
               
                   
                 216822_x_at 
                 AL359763 
                 −1 
                 AL359763 
               
               
                   
                 216813_at 
                 AL512728 
                 −1 
                 AL512728 
               
               
                   
                 202920_at 
                 NM_001148 
                 −1 
                 ANK2 
               
               
                   
                 215764_x_at 
                 AA877641 
                 −1 
                 AP2A2 
               
               
                   
                 201168_x_at 
                 NM_004309 
                 −1 
                 ARHGDIA 
               
               
                   
                 213138_at 
                 M62324 
                 −1 
                 ARID5A 
               
               
                   
                 202208_s_at 
                 BC001051 
                 −1 
                 ARL7 
               
               
                   
                 219996_at 
                 NM_024708 
                 −1 
                 ASB7 
               
               
                   
                 215987_at 
                 AV654984 
                 −1 
                 AV654984 
               
               
                   
                 222303_at 
                 AV700891 
                 −1 
                 AV700891 
               
               
                   
                 222348_at 
                 AW971134 
                 −1 
                 AW971134 
               
               
                   
                 222329_x_at 
                 AW974816 
                 −1 
                 AW974816 
               
               
                   
                 205681_at 
                 NM_004049 
                 −1 
                 BCL2A1 
               
               
                   
                 213281_at 
                 BE327172 
                 −1 
                 BE327172 
               
               
                   
                 217921_at 
                 BE543064 
                 −1 
                 BE543064 
               
               
                   
                 215775_at 
                 BF084105 
                 −1 
                 BF084105 
               
               
                   
                 217591_at 
                 BF725121 
                 −1 
                 BF725121 
               
               
                   
                 201235_s_at 
                 BG339064 
                 −1 
                 BTG2 
               
               
                   
                 220509_at 
                 NM_018605 
                 −1 
                 C13orf10 
               
               
                   
                 201309_x_at 
                 NM_004772 
                 −1 
                 C5orf13 
               
               
                   
                 220614_s_at 
                 NM_024694 
                 −1 
                 C6orf103 
               
               
                   
                 205476_at 
                 NM_004591 
                 −1 
                 CCL20 
               
               
                   
                 205114_s_at 
                 NM_002983 
                 −1 
                 CCL3, 
               
               
                   
                   
                   
                   
                 CCL3L1, 
               
               
                   
                   
                   
                   
                 MGC12815 
               
               
                   
                 201884_at 
                 NM_004363 
                 −1 
                 CEACAM5 
               
               
                   
                 218177_at 
                 NM_020412 
                 −1 
                 CHMP1.5 
               
               
                   
                 216016_at 
                 AK027194 
                 −1 
                 CIAS1 
               
               
                   
                 216015_s_at 
                 AK027194 
                 −1 
                 CIAS1 
               
               
                   
                 206207_at 
                 NM_001828 
                 −1 
                 CLC 
               
               
                   
                 213622_at 
                 AI733465 
                 −1 
                 COL9A2 
               
               
                   
                 213504_at 
                 W63732 
                 −1 
                 COPS6 
               
               
                   
                 204533_at 
                 NM_001565 
                 −1 
                 CXCL10 
               
               
                   
                 203666_at 
                 NM_000609 
                 −1 
                 CXCL12 
               
               
                   
                 209774_x_at 
                 M57731 
                 −1 
                 CXCL2 
               
               
                   
                 207850_at 
                 NM_002090 
                 −1 
                 CXCL3 
               
               
                   
                 214421_x_at 
                 AV652420 
                 −1 
                 CYP2C9 
               
               
                   
                 218013_x_at 
                 NM_016221 
                 −1 
                 DCTN4 
               
               
                   
                 221780_s_at 
                 AF336851 
                 −1 
                 DDX27 
               
               
                   
                 220004_at 
                 NM_018665 
                 −1 
                 DDX43 
               
               
                   
                 221293_s_at 
                 NM_022047 
                 −1 
                 DEF6 
               
               
                   
                 213632_at 
                 M94065 
                 −1 
                 DHODH 
               
               
                   
                 33768_at 
                 L19267 
                 −1 
                 DMWD 
               
               
                   
                 215151_at 
                 AB014594 
                 −1 
                 DOCK10 
               
               
                   
                 201044_x_at 
                 AA530892 
                 −1 
                 DUSP1 
               
               
                   
                 201041_s_at 
                 NM_004417 
                 −1 
                 DUSP1 
               
               
                   
                 204794_at 
                 NM_004418 
                 −1 
                 DUSP2 
               
               
                   
                 213477_x_at 
                 AL515273 
                 −1 
                 EEF1A1 
               
               
                   
                 201694_s_at 
                 NM_001964 
                 −1 
                 EGR1 
               
               
                   
                 201693_s_at 
                 NM_001964 
                 −1 
                 EGR1 
               
               
                   
                 200596_s_at 
                 BE614908 
                 −1 
                 EIF3S10 
               
               
                   
                 204513_s_at 
                 NM_014800 
                 −1 
                 ELMO1 
               
               
                   
                 210651_s_at 
                 L41939 
                 −1 
                 EPHB2 
               
               
                   
                 205767_at 
                 NM_001432 
                 −1 
                 EREG 
               
               
                   
                 212106_at 
                 AB020694 
                 −1 
                 ETEA 
               
               
                   
                 201329_s_at 
                 NM_005239 
                 −1 
                 ETS2 
               
               
                   
                 211307_s_at 
                 U43677 
                 −1 
                 FCAR 
               
               
                   
                 218814_s_at 
                 NM_018252 
                 −1 
                 FLJ10874 
               
               
                   
                 220215_at 
                 NM_024804 
                 −1 
                 FLJ12606 
               
               
                   
                 219397_at 
                 NM_025147 
                 −1 
                 FLJ13448 
               
               
                   
                 218810_at 
                 NM_025079 
                 −1 
                 FLJ23231 
               
               
                   
                 58367_s_at 
                 AA429615 
                 −1 
                 FLJ23233 
               
               
                   
                 219617_at 
                 NM_024766 
                 −1 
                 FLJ23451 
               
               
                   
                 206548_at 
                 NM_024880 
                 −1 
                 FLJ23556 
               
               
                   
                 210414_at 
                 AF169675 
                 −1 
                 FLRT1 
               
               
                   
                 210933_s_at 
                 BC004908 
                 −1 
                 FSCN1 
               
               
                   
                 217370_x_at 
                 S75762 
                 −1 
                 FUS 
               
               
                   
                 209416_s_at 
                 AF083810 
                 −1 
                 FZR1 
               
               
                   
                 215308_at 
                 AF052148 
                 −1 
                 G22P1 
               
               
                   
                 209305_s_at 
                 AF078077 
                 −1 
                 GADD45B 
               
               
                   
                 219954_s_at 
                 NM_020973 
                 −1 
                 GBA3 
               
               
                   
                 207034_s_at 
                 NM_030379 
                 −1 
                 GLI2 
               
               
                   
                 205220_at 
                 NM_006018 
                 −1 
                 GPR109B 
               
               
                   
                 208524_at 
                 NM_005290 
                 −1 
                 GPR15 
               
               
                   
                 209945_s_at 
                 BC000251 
                 −1 
                 GSK3B 
               
               
                   
                 212291_at 
                 AI393355 
                 −1 
                 HIPK1 
               
               
                   
                 208026_at 
                 NM_003540 
                 −1 
                 HIST1H4F 
               
               
                   
                 208729_x_at 
                 D83043 
                 −1 
                 HLA-B 
               
               
                   
                 208812_x_at 
                 BC004489 
                 −1 
                 HLA-C, 
               
               
                   
                   
                   
                   
                 HLA-B 
               
               
                   
                 222126_at 
                 AI247494 
                 −1 
                 HRBL, 
               
               
                   
                   
                   
                   
                 IRS3L 
               
               
                   
                 206708_at 
                 NM_002158 
                 −1 
                 HTLF 
               
               
                   
                 36564_at 
                 W27419 
                 −1 
                 IBRDC3 
               
               
                   
                 202637_s_at 
                 AI608725 
                 −1 
                 ICAM1 
               
               
                   
                 215485_s_at 
                 AA284705 
                 −1 
                 ICAM1 
               
               
                   
                 202638_s_at 
                 NM_000201 
                 −1 
                 ICAM1 
               
               
                   
                 202438_x_at 
                 BF346014 
                 −1 
                 IDS 
               
               
                   
                 202081_at 
                 NM_004907 
                 −1 
                 IER2 
               
               
                   
                 201631_s_at 
                 NM_003897 
                 −1 
                 IER3 
               
               
                   
                 207901_at 
                 NM_002187 
                 −1 
                 IL12B 
               
               
                   
                 210118_s_at 
                 M15329 
                 −1 
                 IL1A 
               
               
                   
                 205067_at 
                 NM_000576 
                 −1 
                 IL1B 
               
               
                   
                 39402_at 
                 M15330 
                 −1 
                 IL1B 
               
               
                   
                 212657_s_at 
                 AW083357 
                 −1 
                 IL1RN 
               
               
                   
                 211506_s_at 
                 AF043337 
                 −1 
                 IL8 
               
               
                   
                 202859_x_at 
                 NM_000584 
                 −1 
                 IL8 
               
               
                   
                 208364_at 
                 NM_001566 
                 −1 
                 INPP4A 
               
               
                   
                 213146_at 
                 AA521267 
                 −1 
                 JMJD3 
               
               
                   
                 41386_i_at 
                 AB002344 
                 −1 
                 JMJD3 
               
               
                   
                 41387_r_at 
                 AB002344 
                 −1 
                 JMJD3 
               
               
                   
                 201465_s_at 
                 BC002646 
                 −1 
                 JUN 
               
               
                   
                 203751_x_at 
                 NM_005354 
                 −1 
                 JUND 
               
               
                   
                 207141_s_at 
                 U39196 
                 −1 
                 KCNJ3 
               
               
                   
                 212057_at 
                 AA206161 
                 −1 
                 KIAA0182 
               
               
                   
                 215137_at 
                 H92070 
                 −1 
                 KIAA0508 
               
               
                   
                 204403_x_at 
                 NM_014719 
                 −1 
                 KIAA0738 
               
               
                   
                 206966_s_at 
                 NM_016285 
                 −1 
                 KLF12 
               
               
                   
                 208467_at 
                 NM_007249 
                 −1 
                 KLF12 
               
               
                   
                 204012_s_at 
                 AL529189 
                 −1 
                 LCMT2 
               
               
                   
                 202068_s_at 
                 NM_000527 
                 −1 
                 LDLR 
               
               
                   
                 215462_at 
                 AI978990 
                 −1 
                 LOC149478 
               
               
                   
                 216084_at 
                 AL080137 
                 −1 
                 LOC389715 
               
               
                   
                 64899_at 
                 AA209463 
                 −1 
                 LPPR2 
               
               
                   
                 205193_at 
                 NM_012323 
                 −1 
                 MAFF 
               
               
                   
                 219442_at 
                 NM_024048 
                 −1 
                 MGC3020 
               
               
                   
                 209231_s_at 
                 BC004191 
                 −1 
                 MGC3248 
               
               
                   
                 207984_s_at 
                 NM_005374 
                 −1 
                 MPP2 
               
               
                   
                 210254_at 
                 L35848 
                 −1 
                 MS4A3 
               
               
                   
                 202247_s_at 
                 NM_004689 
                 −1 
                 MTA1 
               
               
                   
                 212452_x_at 
                 AF113514 
                 −1 
                 MYST4 
               
               
                   
                 205669_at 
                 NM_004540 
                 −1 
                 NCAM2 
               
               
                   
                 200855_at 
                 AW771910 
                 −1 
                 NCOR1 
               
               
                   
                 204888_s_at 
                 AF029729 
                 −1 
                 NEURL 
               
               
                   
                 207535_s_at 
                 NM_002502 
                 −1 
                 NFKB2 
               
               
                   
                 201502_s_at 
                 NM_020529 
                 −1 
                 NFKBIA 
               
               
                   
                 203927_at 
                 NM_004556 
                 −1 
                 NFKBIE 
               
               
                   
                 215720_s_at 
                 AL031778 
                 −1 
                 NFYA 
               
               
                   
                 220856_x_at 
                 NM_014128 
                 −1 
                 NM_014128 
               
               
                   
                 207783_x_at 
                 NM_017627 
                 −1 
                 NM_017627 
               
               
                   
                 208120_x_at 
                 NM_031221 
                 −1 
                 NM_031221 
               
               
                   
                 202340_x_at 
                 NM_002135 
                 −1 
                 NR4A1 
               
               
                   
                 210226_at 
                 D85245 
                 −1 
                 NR4A1 
               
               
                   
                 211973_at 
                 AW341200 
                 −1 
                 NUDT3 
               
               
                   
                 204435_at 
                 NM_014778 
                 −1 
                 NUPL1 
               
               
                   
                 208274_at 
                 NM_022375 
                 −1 
                 OCLM 
               
               
                   
                 213131_at 
                 R38389 
                 −1 
                 OLFM1 
               
               
                   
                 221344_at 
                 NM_013936 
                 −1 
                 OR12D2 
               
               
                   
                 214637_at 
                 BG437034 
                 −1 
                 OSM 
               
               
                   
                 205432_at 
                 NM_002557 
                 −1 
                 OVGP1 
               
               
                   
                 206880_at 
                 NM_005446 
                 −1 
                 P2RXL1 
               
               
                   
                 215823_x_at 
                 U64661 
                 −1 
                 PABPC1, 
               
               
                   
                   
                   
                   
                 PABPC3 
               
               
                   
                 204267_x_at 
                 NM_004203 
                 −1 
                 PKMYT1 
               
               
                   
                 207717_s_at 
                 NM_004572 
                 −1 
                 PKP2 
               
               
                   
                 204691_x_at 
                 NM_003560 
                 −1 
                 PLA2G6 
               
               
                   
                 202924_s_at 
                 AF006005 
                 −1 
                 PLAGL2 
               
               
                   
                 205934_at 
                 NM_006226 
                 −1 
                 PLCL1 
               
               
                   
                 203471_s_at 
                 NM_002664 
                 −1 
                 PLEK 
               
               
                   
                 201489_at 
                 BC005020 
                 −1 
                 PPIF 
               
               
                   
                 37028_at 
                 U83981 
                 −1 
                 PPP1R15A 
               
               
                   
                 202014_at 
                 NM_014330 
                 −1 
                 PPP1R15A 
               
               
                   
                 205643_s_at 
                 NM_004576 
                 −1 
                 PPP2R2B 
               
               
                   
                 203317_at 
                 NM_012455 
                 −1 
                 PSD4 
               
               
                   
                 204748_at 
                 NM_000963 
                 −1 
                 PTGS2 
               
               
                   
                 206157_at 
                 NM_002852 
                 −1 
                 PTX3 
               
               
                   
                 34478_at 
                 X79780 
                 −1 
                 RAB11B 
               
               
                   
                 205461_at 
                 NM_006861 
                 −1 
                 RAB35 
               
               
                   
                 204543_at 
                 NM_005312 
                 −1 
                 RAPGEF1 
               
               
                   
                 203750_s_at 
                 NM_000964 
                 −1 
                 RARA 
               
               
                   
                 209936_at 
                 AF107493 
                 −1 
                 RBM5 
               
               
                   
                 216153_x_at 
                 AK022897 
                 −1 
                 RECK 
               
               
                   
                 209637_s_at 
                 AF030111 
                 −1 
                 RGS12 
               
               
                   
                 221989_at 
                 AW057781 
                 −1 
                 RPL10 
               
               
                   
                 215620_at 
                 AU147182 
                 −1 
                 RREB1 
               
               
                   
                 205485_at 
                 NM_000540 
                 −1 
                 RYR1 
               
               
                   
                 215670_s_at 
                 AK022844 
                 −1 
                 SCAND2 
               
               
                   
                 217331_at 
                 U63542 
                 −1 
                 SCC-112 
               
               
                   
                 208124_s_at 
                 NM_004263 
                 −1 
                 SEMA4F 
               
               
                   
                 213742_at 
                 AW241752 
                 −1 
                 SFRS11 
               
               
                   
                 222169_x_at 
                 N71739 
                 −1 
                 SH2D3A 
               
               
                   
                 214623_at 
                 AA845710 
                 −1 
                 SHFM3P1 
               
               
                   
                 220000_at 
                 NM_003830 
                 −1 
                 SIGLEC5 
               
               
                   
                 210796_x_at 
                 D86359 
                 −1 
                 SIGLEC6 
               
               
                   
                 203125_x_at 
                 AF046997 
                 −1 
                 SLC11A2 
               
               
                   
                 208389_s_at 
                 NM_004171 
                 −1 
                 SLC1A2 
               
               
                   
                 220091_at 
                 NM_017585 
                 −1 
                 SLC2A6 
               
               
                   
                 210001_s_at 
                 AB005043 
                 −1 
                 SOCS1 
               
               
                   
                 203372_s_at 
                 NM_003877 
                 −1 
                 SOCS2 
               
               
                   
                 215223_s_at 
                 W46388 
                 −1 
                 SOD2 
               
               
                   
                 215078_at 
                 AL050388 
                 −1 
                 SOD2 
               
               
                   
                 217576_x_at 
                 BF692958 
                 −1 
                 SOS2 
               
               
                   
                 210693_at 
                 BC001788 
                 −1 
                 SPPL2B 
               
               
                   
                 202021_x_at 
                 AF083441 
                 −1 
                 SUI1 
               
               
                   
                 207684_at 
                 NM_004608 
                 −1 
                 TBX6 
               
               
                   
                 221473_x_at 
                 U49188 
                 −1 
                 TDE1 
               
               
                   
                 211769_x_at 
                 BC006088 
                 −1 
                 TDE1 
               
               
                   
                 201109_s_at 
                 AV726673 
                 −1 
                 THBS1 
               
               
                   
                 201110_s_at 
                 NM_003246 
                 −1 
                 THBS1 
               
               
                   
                 214657_s_at 
                 AU134977 
                 −1 
                 TncRNA 
               
               
                   
                 207113_s_at 
                 NM_000594 
                 −1 
                 TNF 
               
               
                   
                 202643_s_at 
                 AI738896 
                 −1 
                 TNFAIP3 
               
               
                   
                 202644_s_at 
                 NM_006290 
                 −1 
                 TNFAIP3 
               
               
                   
                 206025_s_at 
                 AW188198 
                 −1 
                 TNFAIP6 
               
               
                   
                 216042_at 
                 AI275938 
                 −1 
                 TNFRSF25 
               
               
                   
                 212260_at 
                 AL045800 
                 −1 
                 TNRC15 
               
               
                   
                 204080_at 
                 NM_025077 
                 −1 
                 TOE1 
               
               
                   
                 212869_x_at 
                 AI721229 
                 −1 
                 TPT1 
               
               
                   
                 211943_x_at 
                 AL565449 
                 −1 
                 TPT1 
               
               
                   
                 214327_x_at 
                 AI888178 
                 −1 
                 TPT1 
               
               
                   
                 212284_x_at 
                 BG498776 
                 −1 
                 TPT1 
               
               
                   
                 220205_at 
                 NM_013315 
                 −1 
                 TPTE 
               
               
                   
                 213593_s_at 
                 AW978896 
                 −1 
                 TRA2A 
               
               
                   
                 205558_at 
                 NM_004620 
                 −1 
                 TRAF6 
               
               
                   
                 213191_at 
                 AF070530 
                 −1 
                 TRIF 
               
               
                   
                 209013_x_at 
                 AF091395 
                 −1 
                 TRIO 
               
               
                   
                 207490_at 
                 NM_025019 
                 −1 
                 TUBA4 
               
               
                   
                 201378_s_at 
                 NM_014847 
                 −1 
                 UBAP2L 
               
               
                   
                 215577_at 
                 AU146791 
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                 NM_023929 
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                 NM_003443 
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                 216350_s_at 
                 X52332 
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                 ZNF10 
               
               
                   
                 219228_at 
                 NM_018555 
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                 220836_at 
                 NM_017757 
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                 220086_at 
                 NM_022466 
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                 ZNFN1A5 
               
               
                   
                 43511_s_at 
                 AI201594 
                 1 
                 DKFZp762 
               
               
                   
                   
                   
                   
                 M127 
               
               
                   
                 217480_x_at 
                 M20812 
                 1 
                 Ig kappa 
               
               
                   
                   
                   
                   
                 chain 
               
               
                   
                 212993_at 
                 AA114166 
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                 XP_316923.1 
               
               
                   
                 212583_at 
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                 1 
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                 217239_x_at 
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                 1 
                 AF044592 
               
               
                   
                 210183_x_at 
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                 1 
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                 217939_s_at 
                 NM_017657 
                 1 
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                 1 
                 AI073984 
               
               
                   
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                 1 
                 FKBP8 
               
               
                   
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                 221777_at 
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                 FLJ14827 
               
               
                   
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                 1 
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                 BC001782 
                 1 
                 GAS2L1 
               
               
                   
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                 NM_004877 
                 1 
                 GMFG 
               
               
                   
                 204000_at 
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                 218361_at 
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                 GPX4 
               
               
                   
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                 HBG2 
               
               
                   
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                 HBLD2 
               
               
                   
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                 HLA-DMB 
               
               
                   
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                 HLA-DOB 
               
               
                   
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                 HLA-E 
               
               
                   
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                 HSD17B12 
               
               
                   
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                 HSPC016 
               
               
                   
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                 HSPC142 
               
               
                   
                 221622_s_at 
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                 HT007 
               
               
                   
                 207180_s_at 
                 NM_006410 
                 1 
                 HTAT1P2 
               
               
                   
                 209586_s_at 
                 AF123539 
                 1 
                 HTCD37 
               
               
                   
                 219209_at 
                 NM_022168 
                 1 
                 IFIH1 
               
               
                   
                 203595_s_at 
                 N47725 
                 1 
                 IFIT5 
               
               
                   
                 211868_x_at 
                 AJ225092 
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                 IGHG1 
               
               
                   
                 212592_at 
                 AV733266 
                 1 
                 IGJ 
               
               
                   
                 221651_x_at 
                 BC005332 
                 1 
                 IGKC 
               
               
                   
                 216207_x_at 
                 AW408194 
                 1 
                 IGKV1D-13 
               
               
                   
                 215121_x_at 
                 AA680302 
                 1 
                 IGLC2 
               
               
                   
                 48825_at 
                 AA887083 
                 1 
                 ING4 
               
               
                   
                 204202_at 
                 NM_017604 
                 1 
                 IQCE 
               
               
                   
                 206493_at 
                 NM_000419 
                 1 
                 ITGA2B 
               
               
                   
                 206494_s_at 
                 NM_000419 
                 1 
                 ITGA2B 
               
               
                   
                 211945_s_at 
                 BG500301 
                 1 
                 ITGB1 
               
               
                   
                 216261_at 
                 AI151479 
                 1 
                 ITGB3 
               
               
                   
                 213483_at 
                 AK025679 
                 1 
                 KIAA0073 
               
               
                   
                 202503_s_at 
                 NM_014736 
                 1 
                 KIAA0101 
               
               
                   
                 212149_at 
                 AW470003 
                 1 
                 KIAA0143 
               
               
                   
                 212523_s_at 
                 D63480 
                 1 
                 KIAA0146 
               
               
                   
                 212733_at 
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                 KIAA0226 
               
               
                   
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                 NM_014699 
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                 KIAA0296 
               
               
                   
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                 KIAA0674 
               
               
                   
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                 KIAA0826 
               
               
                   
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                 NM_006737 
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                 KIR3DL2 
               
               
                   
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                 NM_005561 
                 1 
                 LAMP1 
               
               
                   
                 203042_at 
                 NM_002294 
                 1 
                 LAMP2 
               
               
                   
                 221515_s_at 
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                 LCMT1 
               
               
                   
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                 LMAN2L 
               
               
                   
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                 AK024034 
                 1 
                 LOC220686, 
               
               
                   
                   
                   
                   
                 PIK4CA 
               
               
                   
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                 LPXN 
               
               
                   
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                 1 
                 LRMP 
               
               
                   
                 210044_s_at 
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                 LYL1 
               
               
                   
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                 M17S2 
               
               
                   
                 218573_at 
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                 1 
                 MAGEH1 
               
               
                   
                 206854_s_at 
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                 MAP3K7 
               
               
                   
                 222036_s_at 
                 AI859865 
                 1 
                 MCM4 
               
               
                   
                 209199_s_at 
                 L08895 
                 1 
                 MEF2C 
               
               
                   
                 202645_s_at 
                 NM_000244 
                 1 
                 MEN1 
               
               
                   
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                 U95822 
                 1 
                 MFN1 
               
               
                   
                 217022_s_at 
                 S55735 
                 1 
                 MGC27165 
               
               
                   
                 201764_at 
                 NM_024056 
                 1 
                 MGC5576 
               
               
                   
                 214364_at 
                 W84525 
                 1 
                 MGC61716 
               
               
                   
                 213528_at 
                 AL035369 
                 1 
                 MGC9084 
               
               
                   
                 205612_at 
                 NM_007351 
                 1 
                 MMRN1 
               
               
                   
                 218853_s_at 
                 NM_019556 
                 1 
                 MOSPD1 
               
               
                   
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                 1 
                 MRPL22 
               
               
                   
                 203095_at 
                 NM_002453 
                 1 
                 MTIF2 
               
               
                   
                 210386_s_at 
                 BC001906 
                 1 
                 MTX1 
               
               
                   
                 203517_at 
                 NM_006554 
                 1 
                 MTX2 
               
               
                   
                 202960_s_at 
                 NM_000255 
                 1 
                 MUT 
               
               
                   
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                 NM_012333 
                 1 
                 MYCBP 
               
               
                   
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                 NARS 
               
               
                   
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                 1 
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                 1 
                 OGG1 
               
               
                   
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                 RP42 
               
               
                   
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                 209486_at 
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                 SAS10 
               
               
                   
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                 SGCE 
               
               
                   
                 213355_at 
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                 SIAT10 
               
               
                   
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                 219185_at 
                 NM_012241 
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                 SIRT5 
               
               
                   
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                 SLC25A13 
               
               
                   
                 203658_at 
                 BC001689 
                 1 
                 SLC25A20 
               
               
                   
                 215043_s_at 
                 X83301 
                 1 
                 SMA3, SMA5 
               
               
                   
                 207827_x_at 
                 NM_007308 
                 1 
                 SNCA 
               
               
                   
                 206272_at 
                 NM_006542 
                 1 
                 SPHAR 
               
               
                   
                 201273_s_at 
                 NM_003133 
                 1 
                 SRP9 
               
               
                   
                 202811_at 
                 NM_006463 
                 1 
                 STAMBP 
               
               
                   
                 200028_s_at 
                 NM_020151 
                 1 
                 STARD7 
               
               
                   
                 208855_s_at 
                 AF083420 
                 1 
                 STK24 
               
               
                   
                 212990_at 
                 AB020717 
                 1 
                 SYNJ1 
               
               
                   
                 201259_s_at 
                 AI768845 
                 1 
                 SYPL 
               
               
                   
                 221397_at 
                 NM_023921 
                 1 
                 TAS2R10 
               
               
                   
                 209152_s_at 
                 M31523 
                 1 
                 TCF3 
               
               
                   
                 219292_at 
                 NM_018105 
                 1 
                 THAP1 
               
               
                   
                 201447_at 
                 AL567227 
                 1 
                 TIA1 
               
               
                   
                 217979_at 
                 NM_014399 
                 1 
                 TM4SF13 
               
               
                   
                 221246_x_at 
                 NM_018274 
                 1 
                 TNS 
               
               
                   
                 209917_s_at 
                 BC002709 
                 1 
                 TP53AP1 
               
               
                   
                 218095_s_at 
                 BC003545 
                 1 
                 TPARL 
               
               
                   
                 220865_s_at 
                 NM_014317 
                 1 
                 TPRT 
               
               
                   
                 203512_at 
                 NM_014408 
                 1 
                 TRAPPC3 
               
               
                   
                 217958_at 
                 NM_016146 
                 1 
                 TRAPPC4 
               
               
                   
                 204341_at 
                 NM_006470 
                 1 
                 TRIM16 
               
               
                   
                 210705_s_at 
                 AF220028 
                 1 
                 TRIM5 
               
               
                   
                 209778_at 
                 AF007217 
                 1 
                 TRIP11 
               
               
                   
                 215735_s_at 
                 AC005600 
                 1 
                 TSC2 
               
               
                   
                 221253_s_at 
                 NM_030810 
                 1 
                 TXNDC5 
               
               
                   
                 201588_at 
                 NM_004786 
                 1 
                 TXNL1 
               
               
                   
                 218289_s_at 
                 NM_024818 
                 1 
                 UBE1DC1 
               
               
                   
                 203281_s_at 
                 NM_003335 
                 1 
                 UBE1L 
               
               
                   
                 218533_s_at 
                 NM_017859 
                 1 
                 UCKL1 
               
               
                   
                 203583_at 
                 NM_014044 
                 1 
                 UNC50 
               
               
                   
                 209268_at 
                 AF165513 
                 1 
                 VPS45A 
               
               
                   
                 209452_s_at 
                 AF035824 
                 1 
                 VT11B 
               
               
                   
                 220917_s_at 
                 NM_025132 
                 1 
                 WDR19 
               
               
                   
                 217784_at 
                 NM_006555 
                 1 
                 YKT6 
               
               
                   
                 220261_s_at 
                 NM_018106 
                 1 
                 ZDHHC4 
               
               
                   
                 202939_at 
                 NM_005857 
                 1 
                 ZMPSTE24 
               
               
                   
                 201541_s_at 
                 NM_006349 
                 1 
                 ZNHIT1 
               
               
                   
                   
               
               
                   
                 Table 3: Provided are genetic markers which are differentially expressed between subjects diagnosed with probable multiple sclerosis which did not convert to the diagnosis of definite MS (non-convertors) during a two-years follow up and healthy controls (the Probeset ID of the Affymetrix Gene Chip), along with the corresponding GenBank accession number (GenBank Acc. No.), the gene symbol and the direction (Dir) of change in gene expression (“1” - upregulation; “−1” - downregulation). 
               
               
                   
                 Note that the p values of the TNOM, Info and t-Test statistical tests all passed the 95% confidence level. 
               
            
           
         
       
     
     Gene expression pattern of subjects with definite diagnosis of multiple sclerosis—Table 4, hereinbelow, depict 722 genetic markers which are differentially expressed between subjects with a definite diagnosis of multiple sclerosis (both from relapse and remitting phases; blood samples were taken after the diagnosis of definite MS was confirmed, i.e., at least after the second neurological attack) and healthy controls. 
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 Differentially expressed markers between subjects with the 
               
               
                 diagnosis of definite multiple sclerosis and healthy controls 
               
            
           
           
               
               
               
               
               
               
            
               
                 GenBank 
                   
                   
                   
                   
                   
               
               
                 Accession 
                 TNOM 
                 Info 
                 t-Test 
                   
                   
               
               
                 No, 
                 PValue 
                 PValue 
                 PValue 
                 Dir 
                 Gene Symbol 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 AI252582 
                 5.31E−06 
                 5.31E−06 
                 2.46E−05 
                 −1 
                 ATP6V0E 
               
               
                 NM_017686 
                 5.31E−06 
                 5.31E−06 
                 1.44E−05 
                 −1 
                 GDAP2 
               
               
                 NM_006404 
                 2.90E−05 
                 4.28E−05 
                 1.23E−05 
                 −1 
                 PROCR 
               
               
                 NM_003916 
                 1.49E−04 
                 1.49E−04 
                 8.21E−04 
                 −1 
                 AP1S2 
               
               
                 NM_015396 
                 1.49E−04 
                 1.49E−04 
                 2.46E−03 
                 −1 
                 ARMC8 
               
               
                 NM_007212 
                 1.49E−04 
                 3.72E−05 
                 5.28E−05 
                 −1 
                 RNF2 
               
               
                 AL138761 
                 1.49E−04 
                 1.49E−04 
                 3.67E−03 
                 −1 
                 — 
               
               
                 NM_020474 
                 2.70E−04 
                 1.90E−04 
                 2.85E−02 
                 −1 
                 GALNT1 
               
               
                 N21138 
                 2.70E−04 
                 1.90E−04 
                 2.98E−04 
                 −1 
                 RHOBTB3 
               
               
                 NM_015904 
                 1.82E−03 
                 1.47E−03 
                 7.88E−03 
                 −1 
                 EIF5B 
               
               
                 NM_003201 
                 1.82E−03 
                 1.47E−03 
                 4.89E−03 
                 −1 
                 TFAM 
               
               
                 NM_005263 
                 1.82E−03 
                 1.79E−03 
                 1.67E−02 
                 −1 
                 GFI1 
               
               
                 NM_022335 
                 1.82E−03 
                 2.96E−03 
                 1.64E−04 
                 −1 
                 — 
               
               
                 NM_001222 
                 1.82E−03 
                 1.79E−03 
                 3.87E−03 
                 −1 
                 SRP72 
               
               
                 BC002456 
                 1.82E−03 
                 2.96E−03 
                 1.85E−04 
                 −1 
                 — 
               
               
                 AW268817 
                 1.82E−03 
                 1.47E−03 
                 3.21E−02 
                 −1 
                 CDC5L 
               
               
                 AB044661 
                 1.82E−03 
                 3.63E−04 
                 7.50E−05 
                 −1 
                 XAB1 
               
               
                 AK024044 
                 1.82E−03 
                 1.47E−03 
                 8.77E−04 
                 −1 
                 SSA2 
               
               
                 D42055 
                 1.82E−03 
                 1.79E−03 
                 2.32E−03 
                 −1 
                 NEDD4 
               
               
                 BF680255 
                 1.82E−03 
                 9.10E−04 
                 4.33E−03 
                 −1 
                 — 
               
               
                 AW238654 
                 1.82E−03 
                 1.47E−03 
                 1.83E−03 
                 −1 
                 — 
               
               
                 AK024584 
                 1.82E−03 
                 1.47E−03 
                 2.95E−02 
                 −1 
                 — 
               
               
                 L40992 
                 1.82E−03 
                 1.79E−03 
                 2.40E−02 
                 −1 
                 RUNX2 
               
               
                 NM_014159 
                 1.82E−03 
                 1.47E−03 
                 2.75E−03 
                 −1 
                 HYPB 
               
               
                 AL137750 
                 1.82E−03 
                 1.47E−03 
                 1.87E−02 
                 −1 
                 ETNK1 
               
               
                 AL567227 
                 2.01E−03 
                 2.88E−03 
                 3.52E−02 
                 −1 
                 TIA1 
               
               
                 NM_014774 
                 2.01E−03 
                 2.88E−03 
                 4.00E−02 
                 −1 
                 KIAA0494 
               
               
                 AU146275 
                 2.01E−03 
                 1.69E−03 
                 1.55E−02 
                 −1 
                 ZNF161 
               
               
                 NM_002717 
                 2.01E−03 
                 1.69E−03 
                 6.85E−03 
                 −1 
                 PPP2R2A 
               
               
                 NM_004301 
                 2.01E−03 
                 2.88E−03 
                 1.52E−03 
                 −1 
                 ACTL6A 
               
               
                 BE622627 
                 2.01E−03 
                 1.69E−03 
                 1.83E−02 
                 −1 
                 PIK3R3 
               
               
                 NM_005977 
                 2.01E−03 
                 2.55E−04 
                 7.91E−04 
                 −1 
                 RNF6 
               
               
                 NM_003616 
                 2.01E−03 
                 2.88E−03 
                 9.81E−03 
                 −1 
                 SIP1 
               
               
                 NM_005531 
                 2.01E−03 
                 1.69E−03 
                 7.12E−04 
                 −1 
                 IFI16 
               
               
                 NM_005849 
                 2.01E−03 
                 2.88E−03 
                 1.29E−03 
                 −1 
                 IGSF6 
               
               
                 NM_006065 
                 2.01E−03 
                 5.47E−04 
                 1.08E−03 
                 −1 
                 SIRPB1 
               
               
                 NM_003452 
                 2.01E−03 
                 2.88E−03 
                 1.16E−02 
                 −1 
                 ZNF189 
               
               
                 NM_003539 
                 2.01E−03 
                 2.88E−03 
                 2.71E−03 
                 −1 
                 HIST1H4D 
               
               
                 NM_006016 
                 2.01E−03 
                 1.69E−03 
                 1.81E−03 
                 −1 
                 CD164 
               
               
                 AI332962 
                 2.01E−03 
                 1.69E−03 
                 2.36E−03 
                 −1 
                 — 
               
               
                 BC004421 
                 2.01E−03 
                 1.21E−03 
                 1.18E−03 
                 −1 
                 ZNF330 
               
               
                 AB037701 
                 2.01E−03 
                 2.88E−03 
                 5.57E−03 
                 −1 
                 SIP1 
               
               
                 AB000815 
                 2.01E−03 
                 2.88E−03 
                 8.15E−04 
                 −1 
                 ARNTL 
               
               
                 BC006403 
                 2.01E−03 
                 1.21E−03 
                 1.38E−04 
                 −1 
                 NCK1 
               
               
                 AB037703 
                 2.01E−03 
                 2.88E−03 
                 1.25E−02 
                 −1 
                 SIP1 
               
               
                 U90142 
                 2.01E−03 
                 1.21E−03 
                 3.63E−04 
                 −1 
                 BTN2A1 
               
               
                 AF234262 
                 2.01E−03 
                 2.88E−03 
                 1.75E−03 
                 −1 
                 MAP3K2 
               
               
                 M60725 
                 2.01E−03 
                 2.55E−04 
                 1.06E−04 
                 −1 
                 RPS6KB1 
               
               
                 AI057093 
                 2.01E−03 
                 1.69E−03 
                 1.21E−03 
                 −1 
                 RDX 
               
               
                 AL079292 
                 2.01E−03 
                 2.88E−03 
                 1.92E−02 
                 −1 
                 — 
               
               
                 AB002347 
                 2.01E−03 
                 2.55E−04 
                 2.15E−03 
                 −1 
                 C6orf133 
               
               
                 AL033377 
                 2.01E−03 
                 2.88E−03 
                 4.63E−02 
                 −1 
                 GPR126 
               
               
                 AI811577 
                 2.01E−03 
                 1.69E−03 
                 2.03E−03 
                 −1 
                 ZNF184 
               
               
                 AI860341 
                 2.01E−03 
                 1.69E−03 
                 1.06E−03 
                 −1 
                 ACAA1 
               
               
                 AF052146 
                 2.01E−03 
                 2.88E−03 
                 1.12E−03 
                 −1 
                 — 
               
               
                 AK025174 
                 2.01E−03 
                 2.88E−03 
                 4.88E−03 
                 −1 
                 GSDML 
               
               
                 AL096729 
                 2.01E−03 
                 1.69E−03 
                 2.80E−02 
                 −1 
                 GSTA1 
               
               
                 AK026712 
                 2.01E−03 
                 2.88E−03 
                 4.93E−03 
                 −1 
                 — 
               
               
                 AL049325 
                 2.01E−03 
                 2.88E−03 
                 2.30E−02 
                 −1 
                 CCM1 
               
               
                 BC005316 
                 2.01E−03 
                 2.88E−03 
                 2.52E−02 
                 −1 
                 NFYB 
               
               
                 NM_016618 
                 2.01E−03 
                 5.47E−04 
                 6.92E−03 
                 −1 
                 LOC51315 
               
               
                 NM_017423 
                 2.01E−03 
                 2.55E−04 
                 6.86E−04 
                 −1 
                 GALNT7 
               
               
                 NM_018046 
                 2.01E−03 
                 2.88E−03 
                 7.75E−03 
                 −1 
                 VG5Q 
               
               
                 NM_018489 
                 2.01E−03 
                 1.69E−03 
                 3.98E−04 
                 −1 
                 ASH1L 
               
               
                 NM_018293 
                 2.01E−03 
                 1.69E−03 
                 1.80E−03 
                 −1 
                 FLJ10997 
               
               
                 NM_018398 
                 2.01E−03 
                 1.69E−03 
                 8.61E−03 
                 −1 
                 CACNA2D3 
               
               
                 NM_018042 
                 2.01E−03 
                 2.88E−03 
                 1.97E−03 
                 −1 
                 FLJ10260 
               
               
                 NM_022488 
                 2.01E−03 
                 2.88E−03 
                 5.03E−03 
                 −1 
                 APG3L 
               
               
                 NM_030934 
                 2.01E−03 
                 1.69E−03 
                 9.89E−03 
                 −1 
                 C1orf25 
               
               
                 AU157915 
                 2.01E−03 
                 2.88E−03 
                 8.04E−03 
                 −1 
                 YTHDF3 
               
               
                 BG167522 
                 2.01E−03 
                 2.88E−03 
                 2.61E−02 
                 −1 
                 HSPC016 
               
               
                 W72694 
                 2.01E−03 
                 2.55E−04 
                 1.72E−03 
                 −1 
                 FAM26B 
               
               
                 NM_002136 
                 9.49E−03 
                 8.40E−03 
                 1.84E−02 
                 −1 
                 HNRPA1 
               
               
                 NM_005520 
                 9.49E−03 
                 8.40E−03 
                 4.11E−03 
                 −1 
                 HNRPH1 
               
               
                 NM_020474 
                 9.49E−03 
                 1.37E−02 
                 1.53E−02 
                 −1 
                 GALNT1 
               
               
                 NM_004048 
                 9.49E−03 
                 3.33E−03 
                 1.95E−02 
                 −1 
                 B2M 
               
               
                 NM_005415 
                 9.49E−03 
                 7.52E−03 
                 2.69E−03 
                 −1 
                 SLC20A1 
               
               
                 AW051311 
                 9.49E−03 
                 1.56E−02 
                 1.20E−02 
                 −1 
                 KPNA1 
               
               
                 AB020335 
                 9.49E−03 
                 7.52E−03 
                 1.85E−02 
                 −1 
                 SEL1L 
               
               
                 NM_002023 
                 9.49E−03 
                 1.37E−02 
                 6.51E−03 
                 −1 
                 FMOD 
               
               
                 NM_005103 
                 9.49E−03 
                 1.37E−02 
                 1.21E−03 
                 −1 
                 FEZ1 
               
               
                 NM_000609 
                 9.49E−03 
                 7.52E−03 
                 4.73E−02 
                 −1 
                 CXCL12 
               
               
                 NM_003759 
                 9.49E−03 
                 1.37E−02 
                 2.07E−02 
                 −1 
                 SLC4A4 
               
               
                 NM_005589 
                 9.49E−03 
                 1.56E−02 
                 1.03E−02 
                 −1 
                 ALDH6A1 
               
               
                 NM_005630 
                 9.49E−03 
                 1.56E−02 
                 2.48E−02 
                 −1 
                 SLCO2A1 
               
               
                 NM_001046 
                 9.49E−03 
                 1.37E−02 
                 2.06E−03 
                 −1 
                 SLC12A2 
               
               
                 NM_005388 
                 9.49E−03 
                 7.52E−03 
                 2.40E−02 
                 −1 
                 PDCL 
               
               
                 NM_005261 
                 9.49E−03 
                 8.40E−03 
                 7.52E−03 
                 −1 
                 GEM 
               
               
                 NM_014254 
                 9.49E−03 
                 1.56E−02 
                 1.21E−02 
                 −1 
                 TMEM5 
               
               
                 NM_016656 
                 9.49E−03 
                 8.40E−03 
                 7.06E−04 
                 −1 
                 RRAGB 
               
               
                 NM_002147 
                 9.49E−03 
                 7.52E−03 
                 1.86E−02 
                 −1 
                 HOXB5 
               
               
                 NM_004758 
                 9.49E−03 
                 1.37E−02 
                 8.74E−03 
                 −1 
                 BZRAP1 
               
               
                 NM_002547 
                 9.49E−03 
                 1.56E−02 
                 5.79E−03 
                 −1 
                 OPHN1 
               
               
                 NM_007366 
                 9.49E−03 
                 1.37E−02 
                 8.98E−03 
                 −1 
                 PLA2R1 
               
               
                 NM_001340 
                 9.49E−03 
                 8.40E−03 
                 3.60E−03 
                 −1 
                 CYLC2 
               
               
                 NM_015623 
                 9.49E−03 
                 7.52E−03 
                 1.05E−02 
                 −1 
                 DKFZP564D166 
               
               
                 AF116710 
                 9.49E−03 
                 7.52E−03 
                 1.10E−02 
                 −1 
                 RPS14 
               
               
                 BC000914 
                 9.49E−03 
                 7.52E−03 
                 2.46E−03 
                 −1 
                 SFRS3 
               
               
                 U40763 
                 9.49E−03 
                 1.37E−02 
                 7.34E−03 
                 −1 
                 PPIG 
               
               
                 AB023200 
                 9.49E−03 
                 1.56E−02 
                 4.79E−03 
                 −1 
                 C22orf19 
               
               
                 L07515 
                 9.49E−03 
                 3.33E−03 
                 3.32E−04 
                 −1 
                 CBX5 
               
               
                 AB056663 
                 9.49E−03 
                 7.52E−03 
                 1.00E−02 
                 −1 
                 ITCH 
               
               
                 AW003989 
                 9.49E−03 
                 3.63E−04 
                 4.13E−03 
                 −1 
                 C19orf2 
               
               
                 AF130104 
                 9.49E−03 
                 7.52E−03 
                 1.37E−02 
                 −1 
                 — 
               
               
                 BC002713 
                 9.49E−03 
                 7.52E−03 
                 1.04E−02 
                 −1 
                 MXD4 
               
               
                 AF229180 
                 9.49E−03 
                 3.33E−03 
                 4.12E−04 
                 −1 
                 AASS 
               
               
                 BE737027 
                 9.49E−03 
                 7.52E−03 
                 1.79E−03 
                 −1 
                 — 
               
               
                 AI972268 
                 9.49E−03 
                 7.52E−03 
                 1.65E−02 
                 −1 
                 PSME4 
               
               
                 AA148507 
                 9.49E−03 
                 2.52E−03 
                 6.95E−04 
                 −1 
                 SLC7A1 
               
               
                 BG111635 
                 9.49E−03 
                 1.56E−02 
                 2.16E−02 
                 −1 
                 CAST 
               
               
                 AI022882 
                 9.49E−03 
                 1.37E−02 
                 2.36E−03 
                 −1 
                 PAM 
               
               
                 L43577 
                 9.49E−03 
                 7.52E−03 
                 1.52E−02 
                 −1 
                 CXorf40 
               
               
                 BE312027 
                 9.49E−03 
                 8.40E−03 
                 1.81E−03 
                 −1 
                 — 
               
               
                 AK022846 
                 9.49E−03 
                 8.40E−03 
                 1.60E−02 
                 −1 
                 INPP5B 
               
               
                 BG260658 
                 9.49E−03 
                 7.52E−03 
                 2.00E−02 
                 −1 
                 — 
               
               
                 AW007137 
                 9.49E−03 
                 3.63E−04 
                 2.91E−03 
                 −1 
                 — 
               
               
                 AI970731 
                 9.49E−03 
                 1.37E−02 
                 2.38E−02 
                 −1 
                 RPS7 
               
               
                 H71805 
                 9.49E−03 
                 1.56E−02 
                 2.40E−03 
                 −1 
                 — 
               
               
                 AV717561 
                 9.49E−03 
                 1.23E−02 
                 1.55E−03 
                 −1 
                 — 
               
               
                 AI613383 
                 9.49E−03 
                 1.56E−02 
                 4.68E−03 
                 −1 
                 EEF1D 
               
               
                 W87901 
                 9.49E−03 
                 1.37E−02 
                 4.57E−03 
                 −1 
                 — 
               
               
                 AK022065 
                 9.49E−03 
                 8.40E−03 
                 1.10E−03 
                 −1 
                 RAB5A 
               
               
                 AJ010395 
                 9.49E−03 
                 3.33E−03 
                 1.27E−02 
                 −1 
                 DKC1 
               
               
                 AF113008 
                 9.49E−03 
                 2.52E−03 
                 1.04E−03 
                 −1 
                 — 
               
               
                 AL359578 
                 9.49E−03 
                 3.33E−03 
                 1.21E−03 
                 −1 
                 — 
               
               
                 AL049997 
                 9.49E−03 
                 8.40E−03 
                 4.08E−02 
                 −1 
                 — 
               
               
                 U80771 
                 9.49E−03 
                 1.56E−02 
                 9.34E−03 
                 −1 
                 — 
               
               
                 AF041811 
                 9.49E−03 
                 1.56E−02 
                 1.10E−02 
                 −1 
                 NTRK3 
               
               
                 AW088547 
                 9.49E−03 
                 7.52E−03 
                 3.59E−02 
                 −1 
                 — 
               
               
                 NM_006717 
                 9.49E−03 
                 8.40E−03 
                 2.15E−03 
                 −1 
                 SPIN 
               
               
                 NM_018145 
                 9.49E−03 
                 1.56E−02 
                 3.83E−03 
                 −1 
                 FLJ10579 
               
               
                 AA824298 
                 9.49E−03 
                 7.52E−03 
                 3.28E−03 
                 −1 
                 FLJ10036 
               
               
                 NM_016649 
                 9.49E−03 
                 1.37E−02 
                 2.29E−03 
                 −1 
                 C20orf6 
               
               
                 NM_018320 
                 9.49E−03 
                 1.56E−02 
                 1.44E−02 
                 −1 
                 RNF121 
               
               
                 NM_003973 
                 9.49E−03 
                 8.40E−03 
                 4.82E−03 
                 −1 
                 — 
               
               
                 NM_017571 
                 9.49E−03 
                 8.40E−03 
                 3.67E−03 
                 −1 
                 KIAA1212 
               
               
                 NM_022101 
                 9.49E−03 
                 1.37E−02 
                 1.07E−02 
                 −1 
                 FLJ22965 
               
               
                 NM_014155 
                 9.49E−03 
                 7.52E−03 
                 2.76E−02 
                 −1 
                 HSPC063 
               
               
                 NM_024312 
                 9.49E−03 
                 8.40E−03 
                 1.51E−02 
                 −1 
                 MGC4170 
               
               
                 NM_024966 
                 9.49E−03 
                 3.33E−03 
                 1.18E−03 
                 −1 
                 SEMA6D 
               
               
                 NM_018655 
                 9.49E−03 
                 7.52E−03 
                 1.39E−02 
                 −1 
                 LENEP 
               
               
                 AF077053 
                 9.49E−03 
                 2.52E−03 
                 2.54E−03 
                 −1 
                 TAF9L 
               
               
                 BE972394 
                 9.49E−03 
                 1.56E−02 
                 1.79E−03 
                 −1 
                 ZNF131 
               
               
                 BF195165 
                 9.49E−03 
                 1.56E−02 
                 8.62E−03 
                 −1 
                 — 
               
               
                 BF224259 
                 1.74E−02 
                 2.19E−02 
                 2.51E−02 
                 −1 
                 SMNDC1 
               
               
                 BG168896 
                 1.74E−02 
                 2.72E−02 
                 1.16E−02 
                 −1 
                 FNTA 
               
               
                 NM_012248 
                 1.74E−02 
                 7.75E−03 
                 2.21E−03 
                 −1 
                 SEPHS2 
               
               
                 BF739979 
                 1.74E−02 
                 2.72E−02 
                 1.64E−02 
                 −1 
                 FLJ16518 
               
               
                 AF053641 
                 1.74E−02 
                 5.43E−03 
                 2.99E−02 
                 −1 
                 CSE1L 
               
               
                 BC002513 
                 1.74E−02 
                 2.72E−02 
                 1.15E−02 
                 −1 
                 EIF2S1 
               
               
                 NM_001020 
                 1.74E−02 
                 5.43E−03 
                 3.65E−02 
                 −1 
                 RPS16 
               
               
                 NM_003589 
                 1.74E−02 
                 2.19E−02 
                 2.94E−02 
                 −1 
                 CUL4A 
               
               
                 AL567227 
                 1.74E−02 
                 2.19E−02 
                 1.49E−02 
                 −1 
                 TIA1 
               
               
                 NM_022037 
                 1.74E−02 
                 5.43E−03 
                 1.66E−03 
                 −1 
                 TIA1 
               
               
                 NM_002806 
                 1.74E−02 
                 5.43E−03 
                 4.98E−03 
                 −1 
                 PSMC6 
               
               
                 D42063 
                 1.74E−02 
                 2.72E−02 
                 1.35E−02 
                 −1 
                 RANBP2 
               
               
                 AF185696 
                 1.74E−02 
                 2.19E−02 
                 2.04E−02 
                 −1 
                 OSBP 
               
               
                 NM_001560 
                 1.74E−02 
                 2.19E−02 
                 4.92E−02 
                 −1 
                 IL13RA1 
               
               
                 AI984051 
                 1.74E−02 
                 5.47E−04 
                 4.24E−05 
                 −1 
                 THRAP1 
               
               
                 AA156948 
                 1.74E−02 
                 2.19E−02 
                 7.17E−03 
                 −1 
                 PRPF4B 
               
               
                 NM_016553 
                 1.74E−02 
                 7.75E−03 
                 2.86E−03 
                 −1 
                 NUP62 
               
               
                 AF302110 
                 1.74E−02 
                 5.43E−03 
                 7.85E−03 
                 −1 
                 AASDHPPT 
               
               
                 NM_003601 
                 1.74E−02 
                 2.19E−02 
                 1.40E−02 
                 −1 
                 SMARCA5 
               
               
                 NM_006178 
                 1.74E−02 
                 5.43E−03 
                 4.00E−03 
                 −1 
                 NSF 
               
               
                 BC000365 
                 1.74E−02 
                 2.19E−02 
                 8.40E−03 
                 −1 
                 GTF2H1 
               
               
                 AA834576 
                 1.74E−02 
                 5.43E−03 
                 1.05E−02 
                 −1 
                 ITPR2 
               
               
                 NM_003903 
                 1.74E−02 
                 2.19E−02 
                 9.52E−03 
                 −1 
                 CDC16 
               
               
                 NM_006460 
                 1.74E−02 
                 5.43E−03 
                 7.32E−03 
                 −1 
                 HIS1 
               
               
                 NM_004661 
                 1.74E−02 
                 2.19E−02 
                 4.09E−02 
                 −1 
                 CDC23 
               
               
                 NM_003850 
                 1.74E−02 
                 5.43E−03 
                 1.17E−02 
                 −1 
                 SUCLA2 
               
               
                 NM_006421 
                 1.74E−02 
                 2.72E−02 
                 4.86E−02 
                 −1 
                 ARFGEF1 
               
               
                 NM_000255 
                 1.74E−02 
                 2.19E−02 
                 1.71E−02 
                 −1 
                 MUT 
               
               
                 NM_005783 
                 1.74E−02 
                 5.43E−03 
                 3.12E−02 
                 −1 
                 TXNDC9 
               
               
                 NM_013450 
                 1.74E−02 
                 5.43E−03 
                 1.03E−02 
                 −1 
                 BAZ2B 
               
               
                 NM_003194 
                 1.74E−02 
                 2.19E−02 
                 3.67E−02 
                 −1 
                 TBP 
               
               
                 NM_014663 
                 1.74E−02 
                 2.72E−02 
                 1.21E−02 
                 −1 
                 JMJD2A 
               
               
                 BG111661 
                 1.74E−02 
                 2.72E−02 
                 4.74E−02 
                 −1 
                 GOLGA1 
               
               
                 AU157008 
                 1.74E−02 
                 2.72E−02 
                 5.92E−03 
                 −1 
                 PSMD5 
               
               
                 NM_003674 
                 1.74E−02 
                 5.43E−03 
                 3.21E−02 
                 −1 
                 CDK10 
               
               
                 NM_025137 
                 1.74E−02 
                 5.43E−03 
                 1.19E−02 
                 −1 
                 FLJ21439 
               
               
                 NM_021645 
                 1.74E−02 
                 5.43E−03 
                 3.23E−02 
                 −1 
                 UTP14C 
               
               
                 NM_001114 
                 1.74E−02 
                 5.43E−03 
                 3.34E−03 
                 −1 
                 ADCY7 
               
               
                 NM_005923 
                 1.74E−02 
                 1.18E−02 
                 1.58E−03 
                 −1 
                 MAP3K5 
               
               
                 NM_002118 
                 1.74E−02 
                 2.19E−02 
                 3.48E−02 
                 −1 
                 HLA-DMB 
               
               
                 NM_007049 
                 1.74E−02 
                 2.72E−02 
                 8.46E−03 
                 −1 
                 BTN2A1 
               
               
                 NM_005999 
                 1.74E−02 
                 2.19E−02 
                 4.44E−02 
                 −1 
                 TSNAX 
               
               
                 NM_006493 
                 1.74E−02 
                 2.19E−02 
                 2.88E−02 
                 −1 
                 CLN5 
               
               
                 U16307 
                 1.74E−02 
                 5.43E−03 
                 2.50E−03 
                 −1 
                 HRB2 
               
               
                 NM_004379 
                 1.74E−02 
                 2.19E−02 
                 1.85E−03 
                 −1 
                 CREB1 
               
               
                 NM_002048 
                 1.74E−02 
                 2.19E−02 
                 2.16E−02 
                 −1 
                 GAS1 
               
               
                 AB011092 
                 1.74E−02 
                 1.18E−02 
                 1.68E−03 
                 −1 
                 ADCY9 
               
               
                 NM_004898 
                 1.74E−02 
                 2.19E−02 
                 9.45E−03 
                 −1 
                 CLOCK 
               
               
                 NM_003631 
                 1.74E−02 
                 2.43E−02 
                 6.33E−03 
                 −1 
                 PARG 
               
               
                 NM_002643 
                 1.74E−02 
                 2.72E−02 
                 4.22E−02 
                 −1 
                 PIGF 
               
               
                 NM_014950 
                 1.74E−02 
                 2.19E−02 
                 9.23E−03 
                 −1 
                 ZBTB1 
               
               
                 NM_003838 
                 1.74E−02 
                 5.43E−03 
                 1.77E−03 
                 −1 
                 FPGT 
               
               
                 NM_006299 
                 1.74E−02 
                 5.43E−03 
                 4.66E−02 
                 −1 
                 ZNF193 
               
               
                 AF082283 
                 1.74E−02 
                 2.19E−02 
                 4.89E−02 
                 −1 
                 BCL10 
               
               
                 NM_007309 
                 1.74E−02 
                 2.72E−02 
                 1.60E−02 
                 −1 
                 DIAPH2 
               
               
                 NM_020423 
                 1.74E−02 
                 2.72E−02 
                 1.01E−02 
                 −1 
                 PACE-1 
               
               
                 NM_012135 
                 1.74E−02 
                 2.19E−02 
                 4.11E−03 
                 −1 
                 FAM50B 
               
               
                 NM_006300 
                 1.74E−02 
                 2.72E−02 
                 3.98E−02 
                 −1 
                 ZNF230 
               
               
                 NM_006588 
                 1.74E−02 
                 2.19E−02 
                 5.41E−03 
                 −1 
                 HSGP25L2G 
               
               
                 NM_003265 
                 1.74E−02 
                 2.72E−02 
                 4.50E−02 
                 −1 
                 TLR3 
               
               
                 NM_002158 
                 1.74E−02 
                 2.19E−02 
                 1.63E−03 
                 −1 
                 HTLF 
               
               
                 NM_001499 
                 1.74E−02 
                 2.72E−02 
                 1.35E−02 
                 −1 
                 GLE1L 
               
               
                 NM_000647 
                 1.74E−02 
                 5.47E−04 
                 8.05E−04 
                 −1 
                 CCR2 
               
               
                 NM_004858 
                 1.74E−02 
                 2.19E−02 
                 1.38E−03 
                 −1 
                 SLC4A8 
               
               
                 NM_015384 
                 1.74E−02 
                 5.47E−04 
                 3.22E−03 
                 −1 
                 NIPBL 
               
               
                 NM_003438 
                 1.74E−02 
                 5.47E−04 
                 4.76E−04 
                 −1 
                 ZNF137 
               
               
                 NM_024986 
                 1.74E−02 
                 2.19E−02 
                 9.65E−03 
                 −1 
                 FLJ12331 
               
               
                 NM_014812 
                 1.74E−02 
                 5.43E−03 
                 3.21E−03 
                 −1 
                 KAB 
               
               
                 NM_017522 
                 1.74E−02 
                 2.19E−02 
                 4.19E−02 
                 −1 
                 LRP8 
               
               
                 NM_004324 
                 1.74E−02 
                 2.72E−02 
                 3.10E−02 
                 −1 
                 BAX 
               
               
                 AK024823 
                 1.74E−02 
                 2.19E−02 
                 4.04E−03 
                 −1 
                 SUMO2 
               
               
                 AL570661 
                 1.74E−02 
                 2.72E−02 
                 8.23E−03 
                 −1 
                 MCP 
               
               
                 U72937 
                 1.74E−02 
                 2.19E−02 
                 3.01E−02 
                 −1 
                 ATRX 
               
               
                 AW073672 
                 1.74E−02 
                 5.43E−03 
                 3.21E−03 
                 −1 
                 CTNND1 
               
               
                 BG534245 
                 1.74E−02 
                 4.17E−03 
                 2.31E−03 
                 −1 
                 CSNK1A1 
               
               
                 AI659005 
                 1.74E−02 
                 7.75E−03 
                 2.60E−03 
                 −1 
                 LGALS8 
               
               
                 BC005374 
                 1.74E−02 
                 2.19E−02 
                 4.87E−02 
                 −1 
                 TXNDC4 
               
               
                 AF208043 
                 1.74E−02 
                 1.18E−02 
                 2.83E−04 
                 −1 
                 IFI16 
               
               
                 BC002719 
                 1.74E−02 
                 2.72E−02 
                 1.91E−02 
                 −1 
                 EIF3S1 
               
               
                 AF247168 
                 1.74E−02 
                 2.43E−02 
                 3.04E−02 
                 −1 
                 NPD014 
               
               
                 AF006516 
                 1.74E−02 
                 2.19E−02 
                 5.99E−03 
                 −1 
                 ABI1 
               
               
                 NM_001253 
                 1.74E−02 
                 1.18E−02 
                 3.54E−03 
                 −1 
                 CDC5L 
               
               
                 BC003600 
                 1.74E−02 
                 2.19E−02 
                 8.59E−03 
                 −1 
                 LMO4 
               
               
                 AV701283 
                 1.74E−02 
                 2.19E−02 
                 3.30E−03 
                 −1 
                 SEC22L1 
               
               
                 AI753638 
                 1.74E−02 
                 2.19E−02 
                 2.93E−02 
                 −1 
                 OSBPL2 
               
               
                 AF165513 
                 1.74E−02 
                 2.19E−02 
                 4.41E−03 
                 −1 
                 VPS45A 
               
               
                 AF008442 
                 1.74E−02 
                 2.19E−02 
                 8.61E−03 
                 −1 
                 POLR1C 
               
               
                 AF112207 
                 1.74E−02 
                 2.19E−02 
                 1.73E−03 
                 −1 
                 — 
               
               
                 BE963245 
                 1.74E−02 
                 2.19E−02 
                 4.82E−03 
                 −1 
                 FBXW11 
               
               
                 N25915 
                 1.74E−02 
                 2.72E−02 
                 1.41E−02 
                 −1 
                 CUGBP1 
               
               
                 AK001280 
                 1.74E−02 
                 2.19E−02 
                 2.35E−02 
                 −1 
                 HDGFRP3 
               
               
                 AL133600 
                 1.74E−02 
                 5.47E−04 
                 1.41E−03 
                 −1 
                 STAM2 
               
               
                 AF182198 
                 1.74E−02 
                 2.72E−02 
                 8.03E−03 
                 −1 
                 ITSN2 
               
               
                 AF176699 
                 1.74E−02 
                 2.72E−02 
                 5.37E−03 
                 −1 
                 FBXL4 
               
               
                 U22815 
                 1.74E−02 
                 2.19E−02 
                 1.20E−02 
                 −1 
                 PPFIA1 
               
               
                 BC001265 
                 1.74E−02 
                 2.19E−02 
                 3.12E−03 
                 −1 
                 DJ462O23.2 
               
               
                 U89358 
                 1.74E−02 
                 2.19E−02 
                 3.57E−02 
                 −1 
                 L3MBTL 
               
               
                 AB034951 
                 1.74E−02 
                 2.72E−02 
                 4.79E−02 
                 −1 
                 HSPA8 
               
               
                 BC002635 
                 1.74E−02 
                 2.19E−02 
                 4.32E−02 
                 −1 
                 CSF2RA 
               
               
                 AF274935 
                 1.74E−02 
                 2.19E−02 
                 9.75E−03 
                 −1 
                 LOC54499 
               
               
                 BC005259 
                 1.74E−02 
                 2.19E−02 
                 8.41E−03 
                 −1 
                 XRCC4 
               
               
                 AB002382 
                 1.74E−02 
                 2.19E−02 
                 4.24E−03 
                 −1 
                 CTNND1 
               
               
                 BC006181 
                 1.74E−02 
                 2.19E−02 
                 1.59E−02 
                 −1 
                 SFRS1 
               
               
                 AI359472 
                 1.74E−02 
                 2.19E−02 
                 9.72E−03 
                 −1 
                 XTP2 
               
               
                 M27487 
                 1.74E−02 
                 2.72E−02 
                 3.95E−02 
                 −1 
                 HLA-DPA1 
               
               
                 AU143855 
                 1.74E−02 
                 2.72E−02 
                 2.08E−02 
                 −1 
                 PSME4 
               
               
                 BG111260 
                 1.74E−02 
                 2.19E−02 
                 3.20E−03 
                 −1 
                 HIPK1 
               
               
                 AK022910 
                 1.74E−02 
                 5.43E−03 
                 4.83E−04 
                 −1 
                 TNPO3 
               
               
                 AA195936 
                 1.74E−02 
                 5.43E−03 
                 2.79E−02 
                 −1 
                 MGC21416 
               
               
                 AV715767 
                 1.74E−02 
                 2.19E−02 
                 1.14E−02 
                 −1 
                 LIM 
               
               
                 AV745949 
                 1.74E−02 
                 2.72E−02 
                 2.35E−02 
                 −1 
                 SCAMP1 
               
               
                 D26069 
                 1.74E−02 
                 2.72E−02 
                 1.34E−02 
                 −1 
                 CENTB2 
               
               
                 AL080111 
                 1.74E−02 
                 2.19E−02 
                 1.71E−02 
                 −1 
                 NEK7 
               
               
                 AL562282 
                 1.74E−02 
                 2.19E−02 
                 4.97E−02 
                 −1 
                 PP591 
               
               
                 BF970829 
                 1.74E−02 
                 2.19E−02 
                 5.55E−03 
                 −1 
                 OSBPL8 
               
               
                 AI991252 
                 1.74E−02 
                 2.19E−02 
                 2.36E−02 
                 −1 
                 BTN3A2 
               
               
                 AI742305 
                 1.74E−02 
                 4.17E−03 
                 9.52E−05 
                 −1 
                 CHD9 
               
               
                 AA524345 
                 1.74E−02 
                 2.19E−02 
                 1.02E−02 
                 −1 
                 SNX4 
               
               
                 AI752257 
                 1.74E−02 
                 2.72E−02 
                 5.98E−03 
                 −1 
                 ZNF3 
               
               
                 BG548738 
                 1.74E−02 
                 2.72E−02 
                 1.08E−02 
                 −1 
                 KIAA1040 
               
               
                 AB020684 
                 1.74E−02 
                 2.19E−02 
                 1.15E−02 
                 −1 
                 KIAA0877 
               
               
                 AI040324 
                 1.74E−02 
                 2.19E−02 
                 2.72E−03 
                 −1 
                 NCOA2 
               
               
                 AA284075 
                 1.74E−02 
                 2.72E−02 
                 3.24E−03 
                 −1 
                 KNS2 
               
               
                 BE786164 
                 1.74E−02 
                 7.75E−03 
                 2.14E−03 
                 −1 
                 — 
               
               
                 AP000693 
                 1.74E−02 
                 1.18E−02 
                 2.00E−03 
                 −1 
                 ZCWCC3 
               
               
                 N22548 
                 1.74E−02 
                 2.19E−02 
                 1.10E−03 
                 −1 
                 — 
               
               
                 BF970253 
                 1.74E−02 
                 2.19E−02 
                 2.64E−02 
                 −1 
                 FLJ11806 
               
               
                 AV682436 
                 1.74E−02 
                 5.43E−03 
                 1.97E−03 
                 −1 
                 PIK3C2A 
               
               
                 Z78330 
                 1.74E−02 
                 5.43E−03 
                 5.22E−03 
                 −1 
                 ACTR3 
               
               
                 AI041204 
                 1.74E−02 
                 5.47E−04 
                 3.79E−03 
                 −1 
                 CAP350 
               
               
                 AL162056 
                 1.74E−02 
                 2.19E−02 
                 4.90E−02 
                 −1 
                 KIAA1117 
               
               
                 AI823592 
                 1.74E−02 
                 1.18E−02 
                 3.18E−03 
                 −1 
                 KIAA0423 
               
               
                 AI989567 
                 1.74E−02 
                 2.19E−02 
                 3.94E−02 
                 −1 
                 SIAT10 
               
               
                 BF223370 
                 1.74E−02 
                 2.72E−02 
                 2.52E−02 
                 −1 
                 MGC11332 
               
               
                 AW190088 
                 1.74E−02 
                 2.72E−02 
                 3.63E−02 
                 −1 
                 ZNF307 
               
               
                 AI655015 
                 1.74E−02 
                 2.72E−02 
                 1.05E−02 
                 −1 
                 DUSP7 
               
               
                 AA053830 
                 1.74E−02 
                 2.72E−02 
                 3.29E−02 
                 −1 
                 CTBP1 
               
               
                 BE501352 
                 1.74E−02 
                 2.72E−02 
                 9.70E−03 
                 −1 
                 DKFZp667G2110 
               
               
                 AB011097 
                 1.74E−02 
                 2.19E−02 
                 9.50E−03 
                 −1 
                 ARTS-1 
               
               
                 M19720 
                 1.74E−02 
                 4.17E−03 
                 1.92E−03 
                 −1 
                 — 
               
               
                 AI912583 
                 1.74E−02 
                 4.17E−03 
                 2.31E−03 
                 −1 
                 HRB2 
               
               
                 AA890010 
                 1.74E−02 
                 2.19E−02 
                 1.46E−02 
                 −1 
                 — 
               
               
                 AI376724 
                 1.74E−02 
                 5.43E−03 
                 5.94E−04 
                 −1 
                 COX11 
               
               
                 AA209332 
                 1.74E−02 
                 2.19E−02 
                 2.04E−02 
                 −1 
                 OPA1 
               
               
                 N58120 
                 1.74E−02 
                 2.19E−02 
                 6.36E−03 
                 −1 
                 — 
               
               
                 M34356 
                 1.74E−02 
                 2.19E−02 
                 4.08E−02 
                 −1 
                 CREB1 
               
               
                 AK026142 
                 1.74E−02 
                 5.43E−03 
                 4.71E−04 
                 −1 
                 ODAG 
               
               
                 AI357539 
                 1.74E−02 
                 4.17E−03 
                 1.80E−03 
                 −1 
                 LRCH3 
               
               
                 AI571996 
                 1.74E−02 
                 2.19E−02 
                 3.71E−02 
                 −1 
                 STAM2 
               
               
                 AA830884 
                 1.74E−02 
                 2.19E−02 
                 9.07E−03 
                 −1 
                 FMR1 
               
               
                 AA573862 
                 1.74E−02 
                 2.72E−02 
                 2.11E−02 
                 −1 
                 HLA-A 
               
               
                 AL121936 
                 1.74E−02 
                 7.75E−03 
                 2.66E−03 
                 −1 
                 BTN2A1 
               
               
                 AC005614 
                 1.74E−02 
                 2.43E−02 
                 2.52E−03 
                 −1 
                 LOC163131 /// 
               
               
                   
                   
                   
                   
                   
                 LOC284323 
               
               
                 AL163248 
                 1.74E−02 
                 2.19E−02 
                 1.33E−02 
                 −1 
                 ZNF294 
               
               
                 AK024456 
                 1.74E−02 
                 5.47E−04 
                 5.10E−03 
                 −1 
                 FGD2 
               
               
                 AK001861 
                 1.74E−02 
                 4.17E−03 
                 5.47E−04 
                 −1 
                 SNX13 
               
               
                 AK025663 
                 1.74E−02 
                 5.43E−03 
                 1.00E−02 
                 −1 
                 ZNF291 
               
               
                 AK024606 
                 1.74E−02 
                 5.43E−03 
                 1.73E−03 
                 −1 
                 — 
               
               
                 AK025097 
                 1.74E−02 
                 2.19E−02 
                 4.60E−02 
                 −1 
                 — 
               
               
                 AF035299 
                 1.74E−02 
                 5.47E−04 
                 5.00E−03 
                 −1 
                 DOK1 
               
               
                 X69383 
                 1.74E−02 
                 2.43E−02 
                 1.30E−02 
                 −1 
                 — 
               
               
                 S67289 
                 1.74E−02 
                 5.43E−03 
                 3.46E−03 
                 −1 
                 CYBB 
               
               
                 AI339732 
                 1.74E−02 
                 1.21E−03 
                 1.55E−03 
                 −1 
                 CIAO1 
               
               
                 AA719797 
                 1.74E−02 
                 2.19E−02 
                 4.46E−02 
                 −1 
                 OR7E18P 
               
               
                 NM_014052 
                 1.74E−02 
                 2.19E−02 
                 1.90E−03 
                 −1 
                 YWHAB 
               
               
                 NM_014426 
                 1.74E−02 
                 2.72E−02 
                 6.25E−03 
                 −1 
                 SNX5 
               
               
                 NM_018184 
                 1.74E−02 
                 4.17E−03 
                 7.32E−03 
                 −1 
                 ARL10C 
               
               
                 NM_016166 
                 1.74E−02 
                 2.19E−02 
                 1.59E−02 
                 −1 
                 PIAS1 
               
               
                 NM_018442 
                 1.74E−02 
                 2.19E−02 
                 2.87E−02 
                 −1 
                 IQWD1 
               
               
                 NM_018244 
                 1.74E−02 
                 2.19E−02 
                 4.15E−02 
                 −1 
                 C20orf44 
               
               
                 NM_015153 
                 1.74E−02 
                 2.19E−02 
                 1.15E−02 
                 −1 
                 PHF3 
               
               
                 NM_015961 
                 1.74E−02 
                 2.72E−02 
                 3.91E−03 
                 −1 
                 SNF7DC2 
               
               
                 NM_018361 
                 1.74E−02 
                 2.19E−02 
                 1.76E−02 
                 −1 
                 LPAAT-e 
               
               
                 BC005316 
                 1.74E−02 
                 2.72E−02 
                 4.18E−02 
                 −1 
                 NFYB 
               
               
                 NM_018229 
                 1.74E−02 
                 2.19E−02 
                 1.59E−02 
                 −1 
                 C14orf108 
               
               
                 AF195514 
                 1.74E−02 
                 5.47E−04 
                 9.81E−04 
                 −1 
                 VPS4B 
               
               
                 NM_024573 
                 1.74E−02 
                 5.43E−03 
                 3.35E−03 
                 −1 
                 C6orf211 
               
               
                 NM_014028 
                 1.74E−02 
                 2.19E−02 
                 4.90E−02 
                 −1 
                 OSTM1 
               
               
                 NM_001668 
                 1.74E−02 
                 2.19E−02 
                 3.53E−02 
                 −1 
                 ARNT 
               
               
                 NM_022494 
                 1.74E−02 
                 2.19E−02 
                 9.09E−03 
                 −1 
                 ZDHHC6 
               
               
                 NM_022776 
                 1.74E−02 
                 5.47E−04 
                 8.77E−04 
                 −1 
                 OSBPL11 
               
               
                 NM_022067 
                 1.74E−02 
                 2.19E−02 
                 1.91E−02 
                 −1 
                 C14orf133 
               
               
                 NM_020640 
                 1.74E−02 
                 2.19E−02 
                 1.07E−02 
                 −1 
                 RP42 
               
               
                 NM_018115 
                 1.74E−02 
                 1.18E−02 
                 8.56E−04 
                 −1 
                 SDAD1 
               
               
                 NM_017646 
                 1.74E−02 
                 2.19E−02 
                 9.56E−04 
                 −1 
                 TRIT1 
               
               
                 NM_003929 
                 1.74E−02 
                 2.72E−02 
                 2.23E−02 
                 −1 
                 RAB7L1 
               
               
                 NM_017850 
                 1.74E−02 
                 7.75E−03 
                 1.01E−03 
                 −1 
                 FLJ20508 
               
               
                 NM_012123 
                 1.74E−02 
                 2.72E−02 
                 2.21E−02 
                 −1 
                 MTO1 
               
               
                 AK024569 
                 1.74E−02 
                 5.43E−03 
                 1.05E−02 
                 −1 
                 HSPC163 
               
               
                 NM_023010 
                 1.74E−02 
                 2.19E−02 
                 2.12E−03 
                 −1 
                 UPF3B 
               
               
                 NM_025080 
                 1.74E−02 
                 5.43E−03 
                 5.58E−03 
                 −1 
                 ASRGL1 
               
               
                 NM_017810 
                 1.74E−02 
                 2.72E−02 
                 1.59E−02 
                 −1 
                 ZNF434 
               
               
                 NM_018569 
                 1.74E−02 
                 2.19E−02 
                 8.22E−03 
                 −1 
                 C4orf16 
               
               
                 NM_019083 
                 1.74E−02 
                 2.72E−02 
                 2.38E−02 
                 −1 
                 FLJ10287 
               
               
                 AF119868 
                 1.74E−02 
                 5.43E−03 
                 1.89E−02 
                 −1 
                 KIAA1922 
               
               
                 NM_016020 
                 1.74E−02 
                 2.19E−02 
                 1.58E−02 
                 −1 
                 TFB1M 
               
               
                 NM_024638 
                 1.74E−02 
                 1.21E−03 
                 1.92E−03 
                 −1 
                 QTRTD1 
               
               
                 NM_022168 
                 1.74E−02 
                 2.72E−02 
                 9.45E−03 
                 −1 
                 IFIH1 
               
               
                 NM_024828 
                 1.74E−02 
                 2.19E−02 
                 1.58E−03 
                 −1 
                 C9orf82 
               
               
                 NM_024546 
                 1.74E−02 
                 2.19E−02 
                 1.30E−02 
                 −1 
                 C13orf7 
               
               
                 NM_017912 
                 1.74E−02 
                 2.72E−02 
                 4.68E−02 
                 −1 
                 HERC6 
               
               
                 NM_017687 
                 1.74E−02 
                 2.19E−02 
                 2.54E−03 
                 −1 
                 NHLRC2 
               
               
                 NM_024862 
                 1.74E−02 
                 7.75E−03 
                 4.33E−03 
                 −1 
                 FBXO38 
               
               
                 NM_025027 
                 1.74E−02 
                 2.72E−02 
                 3.08E−02 
                 −1 
                 ZNF606 
               
               
                 NM_025231 
                 1.74E−02 
                 4.17E−03 
                 1.49E−03 
                 −1 
                 ZNF435 
               
               
                 NM_022147 
                 1.74E−02 
                 2.19E−02 
                 3.26E−02 
                 −1 
                 IFRG28 
               
               
                 NM_004923 
                 1.74E−02 
                 2.72E−02 
                 1.87E−02 
                 −1 
                 MTL5 
               
               
                 NM_024838 
                 1.74E−02 
                 5.43E−03 
                 1.90E−02 
                 −1 
                 — 
               
               
                 NM_024833 
                 1.74E−02 
                 2.19E−02 
                 3.46E−02 
                 −1 
                 FLJ23506 
               
               
                 NM_007210 
                 1.74E−02 
                 1.21E−03 
                 2.38E−03 
                 −1 
                 GALNT6 
               
               
                 NM_005774 
                 1.74E−02 
                 2.43E−02 
                 2.15E−02 
                 −1 
                 ZNF224 
               
               
                 NM_016424 
                 1.74E−02 
                 2.19E−02 
                 4.40E−03 
                 −1 
                 CROP 
               
               
                 NM_018372 
                 1.74E−02 
                 2.72E−02 
                 3.91E−02 
                 −1 
                 RIF1 
               
               
                 NM_013240 
                 1.74E−02 
                 2.19E−02 
                 2.64E−03 
                 −1 
                 C21orf127 
               
               
                 NM_018327 
                 1.74E−02 
                 5.43E−03 
                 2.08E−02 
                 −1 
                 C20orf38 
               
               
                 NM_015510 
                 1.74E−02 
                 2.72E−02 
                 1.83E−02 
                 −1 
                 DKFZp566O084 
               
               
                 NM_018976 
                 1.74E−02 
                 5.43E−03 
                 8.66E−03 
                 −1 
                 SLC38A2 
               
               
                 NM_030917 
                 1.74E−02 
                 2.19E−02 
                 1.22E−02 
                 −1 
                 FIP1L1 
               
               
                 NM_030911 
                 1.74E−02 
                 1.21E−03 
                 4.68E−04 
                 −1 
                 CDADC1 
               
               
                 NM_030963 
                 1.74E−02 
                 5.43E−03 
                 1.52E−02 
                 −1 
                 RNF146 
               
               
                 AL120704 
                 1.74E−02 
                 2.19E−02 
                 3.01E−02 
                 −1 
                 KPNA3 
               
               
                 BC000039 
                 1.74E−02 
                 1.21E−03 
                 6.70E−04 
                 −1 
                 FAM26B 
               
               
                 AF257135 
                 1.74E−02 
                 2.19E−02 
                 3.46E−02 
                 −1 
                 WBSCR5 
               
               
                 AF274950 
                 1.74E−02 
                 5.43E−03 
                 4.34E−02 
                 −1 
                 FLJ10637 
               
               
                 BC003073 
                 1.74E−02 
                 5.43E−03 
                 1.21E−03 
                 −1 
                 FLJ10521 
               
               
                 AL565516 
                 1.74E−02 
                 2.19E−02 
                 2.11E−02 
                 −1 
                 PANK3 
               
               
                 AI433464 
                 1.74E−02 
                 2.19E−02 
                 3.87E−02 
                 −1 
                 PGM3 
               
               
                 NM_004251 
                 1.74E−02 
                 2.19E−02 
                 3.14E−02 
                 −1 
                 RAB9A 
               
               
                 AW162015 
                 1.74E−02 
                 2.72E−02 
                 6.39E−03 
                 −1 
                 ZNF143 
               
               
                 AW002578 
                 1.74E−02 
                 2.19E−02 
                 3.05E−02 
                 −1 
                 MGC3731 
               
               
                 AI983115 
                 1.74E−02 
                 2.72E−02 
                 9.07E−03 
                 −1 
                 IL27RA 
               
               
                 AW008921 
                 1.74E−02 
                 2.19E−02 
                 3.59E−02 
                 −1 
                 SENP5 
               
               
                 AL137398 
                 1.74E−02 
                 2.72E−02 
                 2.16E−03 
                 −1 
                 DKFZp434P162 
               
               
                 R43279 
                 1.74E−02 
                 4.17E−03 
                 1.74E−03 
                 −1 
                 SNAPC3 
               
               
                 AW975638 
                 1.74E−02 
                 2.19E−02 
                 4.47E−02 
                 −1 
                 — 
               
               
                 AF070618 
                 1.74E−02 
                 2.19E−02 
                 1.09E−02 
                 −1 
                 MRPS22 
               
               
                 U07139 
                 1.74E−02 
                 2.19E−02 
                 4.38E−02 
                 −1 
                 CACNB3 
               
               
                 D29642 
                 1.74E−02 
                 5.47E−04 
                 1.84E−02 
                 −1 
                 ARHGAP25 
               
               
                 AI458463 
                 1.74E−02 
                 5.43E−03 
                 9.08E−03 
                 −1 
                 PACE-1 
               
               
                 Z48481 
                 3.95E−02 
                 2.49E−02 
                 2.75E−02 
                 −1 
                 MMP14 
               
               
                 AV702810 
                 3.95E−02 
                 2.49E−02 
                 6.09E−03 
                 −1 
                 SET 
               
               
                 NM_016451 
                 3.95E−02 
                 4.88E−03 
                 4.12E−03 
                 −1 
                 COPB 
               
               
                 AF205218 
                 3.95E−02 
                 2.52E−03 
                 1.02E−03 
                 −1 
                 IVNS1ABP 
               
               
                 AW968555 
                 3.95E−02 
                 3.54E−02 
                 4.32E−02 
                 −1 
                 TBL1X 
               
               
                 NM_007214 
                 3.95E−02 
                 3.54E−02 
                 3.59E−03 
                 −1 
                 SEC63 
               
               
                 NM_006838 
                 3.95E−02 
                 4.91E−02 
                 1.87E−02 
                 −1 
                 — 
               
               
                 BC000603 
                 3.95E−02 
                 3.54E−02 
                 3.10E−03 
                 −1 
                 — 
               
               
                 BE250417 
                 3.95E−02 
                 4.91E−02 
                 9.76E−03 
                 −1 
                 ZMYND11 
               
               
                 AW183478 
                 3.95E−02 
                 9.26E−03 
                 1.65E−02 
                 −1 
                 STK17A 
               
               
                 NM_015641 
                 3.95E−02 
                 2.49E−02 
                 1.28E−02 
                 −1 
                 TES 
               
               
                 NM_014872 
                 3.95E−02 
                 4.91E−02 
                 2.61E−02 
                 −1 
                 ZBTB5 
               
               
                 NM_014753 
                 3.95E−02 
                 4.91E−02 
                 2.64E−02 
                 −1 
                 BMS1L 
               
               
                 NM_001482 
                 3.95E−02 
                 9.26E−03 
                 7.96E−03 
                 −1 
                 GATM 
               
               
                 NM_000702 
                 3.95E−02 
                 2.49E−02 
                 5.02E−03 
                 −1 
                 ATP1A2 
               
               
                 NM_006214 
                 3.95E−02 
                 3.54E−02 
                 3.50E−02 
                 −1 
                 PHYH 
               
               
                 BG034328 
                 3.95E−02 
                 4.88E−03 
                 5.06E−03 
                 −1 
                 TFDP2 
               
               
                 BG252490 
                 3.95E−02 
                 4.91E−02 
                 2.36E−02 
                 −1 
                 DNAJB4 
               
               
                 NM_016024 
                 3.95E−02 
                 4.91E−02 
                 3.39E−02 
                 −1 
                 RBMX2 
               
               
                 NM_001353 
                 3.95E−02 
                 2.32E−02 
                 6.14E−03 
                 −1 
                 AKR1C1 
               
               
                 NM_000428 
                 3.95E−02 
                 2.49E−02 
                 1.45E−02 
                 −1 
                 LTBP2 
               
               
                 BF224146 
                 3.95E−02 
                 4.91E−02 
                 3.64E−03 
                 −1 
                 TMEM5 
               
               
                 NM_002830 
                 3.95E−02 
                 3.54E−02 
                 2.79E−02 
                 −1 
                 PTPN4 
               
               
                 NM_021077 
                 3.95E−02 
                 4.91E−02 
                 4.77E−02 
                 −1 
                 NMB 
               
               
                 NM_004944 
                 3.95E−02 
                 1.23E−02 
                 3.94E−03 
                 −1 
                 DNASE1L3 
               
               
                 NM_016352 
                 3.95E−02 
                 9.26E−03 
                 1.01E−02 
                 −1 
                 CPA4 
               
               
                 NM_003151 
                 3.95E−02 
                 3.54E−02 
                 1.24E−02 
                 −1 
                 STAT4 
               
               
                 NM_002649 
                 3.95E−02 
                 3.54E−02 
                 2.51E−02 
                 −1 
                 PIK3CG 
               
               
                 NM_024506 
                 3.95E−02 
                 4.91E−02 
                 1.05E−02 
                 −1 
                 GLB1L 
               
               
                 NM_016436 
                 3.95E−02 
                 1.23E−02 
                 2.13E−03 
                 −1 
                 C20orf104 
               
               
                 NM_001240 
                 3.95E−02 
                 2.32E−02 
                 5.79E−03 
                 −1 
                 CCNT1 
               
               
                 NM_006610 
                 3.95E−02 
                 2.32E−02 
                 3.17E−02 
                 −1 
                 MASP2 
               
               
                 NM_002385 
                 3.95E−02 
                 3.54E−02 
                 4.24E−02 
                 −1 
                 MBP 
               
               
                 BG494940 
                 3.95E−02 
                 4.91E−02 
                 1.96E−02 
                 −1 
                 SSA2 
               
               
                 NM_014257 
                 3.95E−02 
                 1.75E−02 
                 6.26E−03 
                 −1 
                 CD209L 
               
               
                 NM_007068 
                 3.95E−02 
                 3.54E−02 
                 3.77E−02 
                 −1 
                 DMC1 
               
               
                 AF208850 
                 3.95E−02 
                 4.91E−02 
                 1.60E−02 
                 −1 
                 PTP4A2 
               
               
                 AF116710 
                 3.95E−02 
                 1.75E−02 
                 9.09E−03 
                 −1 
                 RPS14 
               
               
                 BC001019 
                 3.95E−02 
                 1.23E−02 
                 1.21E−02 
                 −1 
                 RPL39 
               
               
                 BC000734 
                 3.95E−02 
                 4.58E−02 
                 1.57E−02 
                 −1 
                 EIF3S6 
               
               
                 AF226044 
                 3.95E−02 
                 4.91E−02 
                 4.07E−02 
                 −1 
                 SNRK 
               
               
                 AY008372 
                 3.95E−02 
                 3.54E−02 
                 2.90E−02 
                 −1 
                 OSBPL3 
               
               
                 AF271775 
                 3.95E−02 
                 3.54E−02 
                 5.26E−03 
                 −1 
                 LAT1-3TM 
               
               
                 U79526 
                 3.95E−02 
                 3.54E−02 
                 2.21E−02 
                 −1 
                 CMKLR1 
               
               
                 AF031137 
                 3.95E−02 
                 3.54E−02 
                 9.11E−03 
                 −1 
                 NCR3 
               
               
                 AB006589 
                 3.95E−02 
                 2.49E−02 
                 3.80E−02 
                 −1 
                 ESR2 
               
               
                 AF000381 
                 3.95E−02 
                 4.58E−02 
                 9.92E−03 
                 −1 
                 — 
               
               
                 BE466128 
                 3.95E−02 
                 3.54E−02 
                 2.57E−02 
                 −1 
                 RBM25 
               
               
                 AI631874 
                 3.95E−02 
                 3.54E−02 
                 7.58E−03 
                 −1 
                 CSNK2A1 
               
               
                 BG403834 
                 3.95E−02 
                 2.49E−02 
                 2.54E−02 
                 −1 
                 KPNA6 
               
               
                 AW593213 
                 3.95E−02 
                 1.23E−02 
                 1.83E−03 
                 −1 
                 KIAA1078 
               
               
                 BF214492 
                 3.95E−02 
                 7.66E−04 
                 3.51E−03 
                 −1 
                 RPL5 
               
               
                 AA521269 
                 3.95E−02 
                 4.58E−02 
                 1.11E−02 
                 −1 
                 — 
               
               
                 BF739959 
                 3.95E−02 
                 1.23E−02 
                 1.31E−02 
                 −1 
                 MFHAS1 
               
               
                 AW302047 
                 3.95E−02 
                 4.91E−02 
                 6.80E−03 
                 −1 
                 — 
               
               
                 AI252582 
                 3.95E−02 
                 2.49E−02 
                 1.10E−03 
                 −1 
                 — 
               
               
                 AI539361 
                 3.95E−02 
                 1.23E−02 
                 1.39E−02 
                 −1 
                 — 
               
               
                 NM_012081 
                 3.95E−02 
                 4.58E−02 
                 1.28E−02 
                 −1 
                 ELL2 
               
               
                 AA400421 
                 3.95E−02 
                 4.91E−02 
                 2.82E−02 
                 −1 
                 TWISTNB 
               
               
                 AK023851 
                 3.95E−02 
                 4.88E−03 
                 1.60E−03 
                 −1 
                 CAPN2 
               
               
                 BE000837 
                 3.95E−02 
                 1.23E−02 
                 1.96E−03 
                 −1 
                 KIAA0220 
               
               
                 AL121891 
                 3.95E−02 
                 3.54E−02 
                 3.37E−03 
                 −1 
                 UBCE7IP5 
               
               
                 AK023621 
                 3.95E−02 
                 9.26E−03 
                 1.74E−02 
                 −1 
                 RHOBTB3 
               
               
                 S69182 
                 3.95E−02 
                 4.88E−03 
                 3.02E−03 
                 −1 
                 — 
               
               
                 AK026521 
                 3.95E−02 
                 3.54E−02 
                 6.64E−03 
                 −1 
                 TAF1B 
               
               
                 AL354872 
                 3.95E−02 
                 3.54E−02 
                 4.77E−02 
                 −1 
                 CTH 
               
               
                 NM_022731 
                 3.95E−02 
                 4.88E−03 
                 4.52E−03 
                 −1 
                 NUCKS 
               
               
                 NM_020239 
                 3.95E−02 
                 3.54E−02 
                 1.25E−02 
                 −1 
                 CDC42SE1 
               
               
                 NM_022365 
                 3.95E−02 
                 3.54E−02 
                 2.20E−02 
                 −1 
                 DNAJC1 
               
               
                 AV682567 
                 3.95E−02 
                 3.54E−02 
                 4.39E−02 
                 −1 
                 MDS010 
               
               
                 NM_024779 
                 3.95E−02 
                 2.49E−02 
                 2.19E−02 
                 −1 
                 PIP5K2C 
               
               
                 NM_016052 
                 3.95E−02 
                 4.88E−03 
                 2.26E−03 
                 −1 
                 CGI-115 
               
               
                 NM_022073 
                 3.95E−02 
                 4.91E−02 
                 4.41E−02 
                 −1 
                 EGLN3 
               
               
                 NM_013281 
                 3.95E−02 
                 2.49E−02 
                 3.12E−02 
                 −1 
                 FLRT3 
               
               
                 NM_016122 
                 3.95E−02 
                 3.54E−02 
                 9.15E−03 
                 −1 
                 NY-REN-58 
               
               
                 NM_024084 
                 3.95E−02 
                 2.49E−02 
                 8.27E−03 
                 −1 
                 MGC3196 
               
               
                 NM_017860 
                 3.95E−02 
                 3.54E−02 
                 3.82E−03 
                 −1 
                 FLJ20519 
               
               
                 NM_023034 
                 3.95E−02 
                 2.32E−02 
                 1.26E−02 
                 −1 
                 WHSC1L1 
               
               
                 NM_002548 
                 3.95E−02 
                 2.49E−02 
                 2.42E−02 
                 −1 
                 OR1D2 
               
               
                 AL136733 
                 3.95E−02 
                 4.91E−02 
                 1.29E−02 
                 −1 
                 UBAP1 
               
               
                 BC005934 
                 3.95E−02 
                 2.32E−02 
                 1.83E−03 
                 −1 
                 FLJ21168 
               
               
                 AW303136 
                 3.95E−02 
                 4.88E−03 
                 2.28E−03 
                 −1 
                 — 
               
               
                 W87634 
                 3.95E−02 
                 2.49E−02 
                 6.65E−03 
                 −1 
                 CXorf33 
               
               
                 AI669379 
                 3.95E−02 
                 4.91E−02 
                 1.28E−02 
                 −1 
                 — 
               
               
                 BG025063 
                 3.95E−02 
                 3.54E−02 
                 3.63E−02 
                 −1 
                 — 
               
               
                 NM_014622 
                 1.49E−04 
                 1.49E−04 
                 2.75E−03 
                 1 
                 LOH11CR2A 
               
               
                 M87268 
                 1.49E−04 
                 1.49E−04 
                 1.71E−03 
                 1 
                 IGHG1 
               
               
                 NM_024588 
                 1.49E−04 
                 1.49E−04 
                 4.18E−03 
                 1 
                 FLJ23584 
               
               
                 NM_030926 
                 1.49E−04 
                 3.72E−05 
                 2.14E−04 
                 1 
                 ITM2C 
               
               
                 NM_021173 
                 2.70E−04 
                 2.34E−04 
                 1.25E−04 
                 1 
                 POLD4 
               
               
                 NM_014403 
                 2.70E−04 
                 4.40E−04 
                 1.20E−04 
                 1 
                 SIAT7D 
               
               
                 NM_004930 
                 1.82E−03 
                 9.10E−04 
                 8.75E−04 
                 1 
                 CAPZB 
               
               
                 AF129756 
                 1.82E−03 
                 2.96E−03 
                 1.39E−02 
                 1 
                 BAT2 
               
               
                 AL096733 
                 1.82E−03 
                 2.96E−03 
                 2.18E−03 
                 1 
                 ATP6V0A1 
               
               
                 W74620 
                 1.82E−03 
                 1.47E−03 
                 8.07E−04 
                 1 
                 HNRPD 
               
               
                 AC002544 
                 1.82E−03 
                 1.79E−03 
                 2.14E−02 
                 1 
                 LOC283970 
               
               
                 AF008937 
                 1.82E−03 
                 8.95E−05 
                 4.76E−06 
                 1 
                 STX16 
               
               
                 NM_006284 
                 2.01E−03 
                 2.88E−03 
                 3.75E−02 
                 1 
                 TAF10 
               
               
                 BF969352 
                 2.01E−03 
                 2.88E−03 
                 6.33E−04 
                 1 
                 ECE1 
               
               
                 AA675892 
                 2.01E−03 
                 1.69E−03 
                 9.55E−04 
                 1 
                 TOB1 
               
               
                 NM_004395 
                 2.01E−03 
                 2.88E−03 
                 1.56E−02 
                 1 
                 DBN1 
               
               
                 NM_000558 
                 2.01E−03 
                 2.88E−03 
                 1.18E−03 
                 1 
                 HBA1 /// HBA2 
               
               
                 NM_002412 
                 2.01E−03 
                 2.88E−03 
                 2.62E−03 
                 1 
                 MGMT 
               
               
                 NM_003955 
                 2.01E−03 
                 1.69E−03 
                 3.20E−02 
                 1 
                 SOCS3 
               
               
                 NM_004089 
                 2.01E−03 
                 1.69E−03 
                 4.98E−04 
                 1 
                 DSIPI 
               
               
                 AF022231 
                 2.01E−03 
                 2.88E−03 
                 2.04E−03 
                 1 
                 CTDSP2 
               
               
                 AL110191 
                 2.01E−03 
                 1.69E−03 
                 4.57E−04 
                 1 
                 DSIPI 
               
               
                 M25079 
                 2.01E−03 
                 2.88E−03 
                 1.68E−03 
                 1 
                 HBB 
               
               
                 L01639 
                 2.01E−03 
                 2.88E−03 
                 5.25E−03 
                 1 
                 CXCR4 
               
               
                 AF105974 
                 2.01E−03 
                 2.88E−03 
                 1.36E−03 
                 1 
                 HBA1 /// HBA2 
               
               
                 L07555 
                 2.01E−03 
                 2.88E−03 
                 9.46E−03 
                 1 
                 CD69 
               
               
                 AF167343 
                 2.01E−03 
                 2.88E−03 
                 1.04E−02 
                 1 
                 IL1RAP 
               
               
                 AF116676 
                 2.01E−03 
                 2.88E−03 
                 1.99E−02 
                 1 
                 MYL4 
               
               
                 AF349114 
                 2.01E−03 
                 2.88E−03 
                 1.56E−03 
                 1 
                 HBB 
               
               
                 AF349571 
                 2.01E−03 
                 2.88E−03 
                 1.59E−03 
                 1 
                 HBA1 /// HBA2 
               
               
                 BC005931 
                 2.01E−03 
                 2.88E−03 
                 1.33E−03 
                 1 
                 HBA1 
               
               
                 AJ225092 
                 2.01E−03 
                 2.88E−03 
                 5.25E−03 
                 1 
                 IGHG1 
               
               
                 AF348491 
                 2.01E−03 
                 2.88E−03 
                 7.22E−03 
                 1 
                 CXCR4 
               
               
                 T50399 
                 2.01E−03 
                 2.88E−03 
                 1.29E−03 
                 1 
                 HBA2 
               
               
                 AJ275355 
                 2.01E−03 
                 1.21E−03 
                 5.42E−04 
                 1 
                 MGC27165 
               
               
                 AJ249377 
                 2.01E−03 
                 2.88E−03 
                 5.89E−03 
                 1 
                 IGLJ3 
               
               
                 AF059180 
                 2.01E−03 
                 2.88E−03 
                 1.99E−03 
                 1 
                 HBB 
               
               
                 AJ275374 
                 2.01E−03 
                 1.69E−03 
                 3.02E−03 
                 1 
                 — 
               
               
                 V00489 
                 2.01E−03 
                 2.88E−03 
                 1.63E−03 
                 1 
                 HBA2 
               
               
                 NM_024299 
                 2.01E−03 
                 1.69E−03 
                 1.98E−02 
                 1 
                 C20orf149 
               
               
                 NM_020360 
                 2.01E−03 
                 1.69E−03 
                 3.92E−03 
                 1 
                 PLSCR3 
               
               
                 NM_017679 
                 2.01E−03 
                 1.21E−03 
                 1.93E−04 
                 1 
                 BCAS3 
               
               
                 AF230924 
                 2.01E−03 
                 2.88E−03 
                 6.68E−03 
                 1 
                 C6orf82 
               
               
                 AA523441 
                 2.01E−03 
                 2.88E−03 
                 6.97E−04 
                 1 
                 PEX16 
               
               
                 NM_005186 
                 9.49E−03 
                 1.56E−02 
                 1.12E−02 
                 1 
                 CAPN1 
               
               
                 BF304759 
                 9.49E−03 
                 7.52E−03 
                 3.75E−02 
                 1 
                 LRP1 
               
               
                 NM_001662 
                 9.49E−03 
                 8.40E−03 
                 4.40E−03 
                 1 
                 ARF5 
               
               
                 AF113019 
                 9.49E−03 
                 7.52E−03 
                 3.36E−03 
                 1 
                 SMARCD2 
               
               
                 NM_003025 
                 9.49E−03 
                 7.52E−03 
                 2.68E−02 
                 1 
                 SH3GL1 
               
               
                 NM_014846 
                 9.49E−03 
                 1.37E−02 
                 4.68E−02 
                 1 
                 KIAA0196 
               
               
                 NM_017458 
                 9.49E−03 
                 1.23E−02 
                 2.56E−03 
                 1 
                 MVP 
               
               
                 NM_006243 
                 9.49E−03 
                 1.56E−02 
                 4.40E−02 
                 1 
                 PPP2R5A 
               
               
                 NM_001985 
                 9.49E−03 
                 1.56E−02 
                 3.40E−02 
                 1 
                 ETFB 
               
               
                 NM_016621 
                 9.49E−03 
                 1.37E−02 
                 3.12E−02 
                 1 
                 BHC80 
               
               
                 NM_004565 
                 9.49E−03 
                 1.23E−02 
                 1.37E−03 
                 1 
                 PEX14 
               
               
                 NM_005509 
                 9.49E−03 
                 1.56E−02 
                 1.43E−02 
                 1 
                 DMXL1 
               
               
                 NM_005224 
                 9.49E−03 
                 9.26E−03 
                 8.52E−03 
                 1 
                 ARID3A 
               
               
                 NM_003070 
                 9.49E−03 
                 1.56E−02 
                 1.21E−02 
                 1 
                 SMARCA2 
               
               
                 AI810484 
                 9.49E−03 
                 3.63E−04 
                 4.25E−03 
                 1 
                 CBFA2T2 
               
               
                 AF226990 
                 9.49E−03 
                 1.37E−02 
                 2.39E−02 
                 1 
                 HLA-G 
               
               
                 U78774 
                 9.49E−03 
                 7.52E−03 
                 1.03E−02 
                 1 
                 NFYC 
               
               
                 U71088 
                 9.49E−03 
                 3.63E−04 
                 1.69E−03 
                 1 
                 MAP2K5 
               
               
                 AA085748 
                 9.49E−03 
                 1.56E−02 
                 1.69E−02 
                 1 
                 LOC149603 
               
               
                 AB011126 
                 9.49E−03 
                 8.40E−03 
                 2.72E−03 
                 1 
                 FNBP1 
               
               
                 BF570210 
                 9.49E−03 
                 1.37E−02 
                 4.19E−03 
                 1 
                 PNPLA2 
               
               
                 AI343248 
                 9.49E−03 
                 1.37E−02 
                 7.03E−03 
                 1 
                 SRP46 
               
               
                 AA126728 
                 9.49E−03 
                 7.52E−03 
                 2.86E−02 
                 1 
                 ICAM2 
               
               
                 N36926 
                 9.49E−03 
                 8.40E−03 
                 1.13E−02 
                 1 
                 GNA11 
               
               
                 AA602532 
                 9.49E−03 
                 8.40E−03 
                 1.41E−02 
                 1 
                 CLN2 
               
               
                 BE898639 
                 9.49E−03 
                 8.40E−03 
                 1.18E−02 
                 1 
                 ADD1 
               
               
                 AV724215 
                 9.49E−03 
                 1.56E−02 
                 2.07E−02 
                 1 
                 — 
               
               
                 AK001574 
                 9.49E−03 
                 1.37E−02 
                 3.28E−03 
                 1 
                 GORASP1 
               
               
                 BF034906 
                 9.49E−03 
                 8.40E−03 
                 2.75E−03 
                 1 
                 PL6 
               
               
                 AL121981 
                 9.49E−03 
                 3.33E−03 
                 1.69E−03 
                 1 
                 DLG1 
               
               
                 NM_024531 
                 9.49E−03 
                 7.52E−03 
                 1.12E−02 
                 1 
                 GPR172A 
               
               
                 NM_016274 
                 9.49E−03 
                 8.40E−03 
                 1.75E−03 
                 1 
                 CKIP-1 
               
               
                 NM_004542 
                 9.49E−03 
                 7.52E−03 
                 1.25E−02 
                 1 
                 NDUFA3 
               
               
                 NM_007254 
                 9.49E−03 
                 1.37E−02 
                 4.31E−03 
                 1 
                 PNKP 
               
               
                 NM_015711 
                 9.49E−03 
                 1.37E−02 
                 1.96E−03 
                 1 
                 GLTSCR1 
               
               
                 NM_022350 
                 9.49E−03 
                 1.56E−02 
                 4.57E−02 
                 1 
                 LRAP 
               
               
                 NM_017915 
                 9.49E−03 
                 1.56E−02 
                 3.46E−02 
                 1 
                 FLJ20641 
               
               
                 AK026970 
                 9.49E−03 
                 7.52E−03 
                 1.53E−03 
                 1 
                 STX16 
               
               
                 AF078847 
                 9.49E−03 
                 1.37E−02 
                 3.27E−02 
                 1 
                 GTF2H2 
               
               
                 AI828531 
                 9.49E−03 
                 1.56E−02 
                 1.01E−02 
                 1 
                 WIZ 
               
               
                 NM_001344 
                 1.74E−02 
                 2.19E−02 
                 2.80E−02 
                 1 
                 DAD1 
               
               
                 NM_006184 
                 1.74E−02 
                 2.19E−02 
                 3.03E−03 
                 1 
                 NUCB1 
               
               
                 NM_002743 
                 1.74E−02 
                 2.19E−02 
                 8.32E−03 
                 1 
                 PRKCSH 
               
               
                 NM_007245 
                 1.74E−02 
                 2.43E−02 
                 3.73E−03 
                 1 
                 ATXN2L 
               
               
                 NM_015853 
                 1.74E−02 
                 2.19E−02 
                 7.03E−03 
                 1 
                 LOC51035 
               
               
                 NM_003367 
                 1.74E−02 
                 2.72E−02 
                 3.92E−02 
                 1 
                 USF2 
               
               
                 NM_025195 
                 1.74E−02 
                 2.19E−02 
                 4.92E−03 
                 1 
                 TRIB1 
               
               
                 BE675849 
                 1.74E−02 
                 2.19E−02 
                 4.29E−02 
                 1 
                 C9orf60 
               
               
                 BC000436 
                 1.74E−02 
                 2.19E−02 
                 1.14E−02 
                 1 
                 ENSA 
               
               
                 NM_006732 
                 1.74E−02 
                 2.19E−02 
                 1.84E−02 
                 1 
                 FOSB 
               
               
                 NM_019058 
                 1.74E−02 
                 2.72E−02 
                 1.70E−02 
                 1 
                 DDIT4 
               
               
                 NM_020248 
                 1.74E−02 
                 2.19E−02 
                 2.01E−02 
                 1 
                 CTNNBIP1 
               
               
                 NM_003364 
                 1.74E−02 
                 2.72E−02 
                 3.03E−02 
                 1 
                 UPP1 
               
               
                 NM_016294 
                 1.74E−02 
                 2.19E−02 
                 9.73E−03 
                 1 
                 PPP6C 
               
               
                 NM_014569 
                 1.74E−02 
                 2.19E−02 
                 1.31E−02 
                 1 
                 ZFP95 
               
               
                 NM_005354 
                 1.74E−02 
                 2.72E−02 
                 3.91E−02 
                 1 
                 JUND 
               
               
                 NM_004994 
                 1.74E−02 
                 2.72E−02 
                 3.80E−03 
                 1 
                 MMP9 
               
               
                 NM_021127 
                 1.74E−02 
                 2.19E−02 
                 4.47E−02 
                 1 
                 PMAIP1 
               
               
                 NM_002460 
                 1.74E−02 
                 2.19E−02 
                 4.63E−02 
                 1 
                 IRF4 
               
               
                 NM_002201 
                 1.74E−02 
                 2.72E−02 
                 3.88E−03 
                 1 
                 ISG20 
               
               
                 NM_004073 
                 1.74E−02 
                 2.19E−02 
                 1.47E−02 
                 1 
                 PLK3 
               
               
                 NM_005738 
                 1.74E−02 
                 2.19E−02 
                 4.15E−02 
                 1 
                 ARL4A 
               
               
                 NM_014716 
                 1.74E−02 
                 2.19E−02 
                 1.32E−02 
                 1 
                 CENTB1 
               
               
                 BG035761 
                 1.74E−02 
                 5.43E−03 
                 1.26E−02 
                 1 
                 SOCS3 
               
               
                 NM_018134 
                 1.74E−02 
                 2.19E−02 
                 3.27E−02 
                 1 
                 IQCC 
               
               
                 NM_000519 
                 1.74E−02 
                 2.19E−02 
                 2.23E−02 
                 1 
                 HBD 
               
               
                 NM_003811 
                 1.74E−02 
                 1.18E−02 
                 1.57E−02 
                 1 
                 TNFSF9 
               
               
                 NM_005191 
                 1.74E−02 
                 2.19E−02 
                 8.99E−03 
                 1 
                 CD80 
               
               
                 NM_017528 
                 1.74E−02 
                 4.17E−03 
                 9.17E−04 
                 1 
                 WBSCR22 
               
               
                 NM_002620 
                 1.74E−02 
                 2.72E−02 
                 4.54E−02 
                 1 
                 PF4V1 
               
               
                 NM_000423 
                 1.74E−02 
                 2.19E−02 
                 7.31E−04 
                 1 
                 KRT2A 
               
               
                 AL578551 
                 1.74E−02 
                 2.19E−02 
                 4.25E−03 
                 1 
                 RNF10 
               
               
                 U91543 
                 1.74E−02 
                 2.72E−02 
                 1.55E−02 
                 1 
                 CHD3 
               
               
                 BC004242 
                 1.74E−02 
                 2.19E−02 
                 6.76E−03 
                 1 
                 HNRPUL1 
               
               
                 U03886 
                 1.74E−02 
                 2.72E−02 
                 2.05E−02 
                 1 
                 PNPLA4 
               
               
                 M36172 
                 1.74E−02 
                 2.19E−02 
                 3.03E−02 
                 1 
                 MYL4 
               
               
                 U20498 
                 1.74E−02 
                 2.19E−02 
                 6.66E−03 
                 1 
                 CDKN2D 
               
               
                 BC000383 
                 1.74E−02 
                 4.17E−03 
                 3.83E−02 
                 1 
                 WTAP 
               
               
                 BC006383 
                 1.74E−02 
                 5.43E−03 
                 4.42E−04 
                 1 
                 GPAA1 
               
               
                 AY026505 
                 1.74E−02 
                 5.43E−03 
                 8.99E−04 
                 1 
                 KIF2C 
               
               
                 U17074 
                 1.74E−02 
                 2.19E−02 
                 1.23E−02 
                 1 
                 CDKN2C 
               
               
                 D87858 
                 1.74E−02 
                 2.19E−02 
                 3.94E−02 
                 1 
                 FCAR 
               
               
                 AI827941 
                 1.74E−02 
                 5.43E−03 
                 1.32E−03 
                 1 
                 MYH9 
               
               
                 BE968833 
                 1.74E−02 
                 2.72E−02 
                 2.71E−02 
                 1 
                 SPTBN1 
               
               
                 AK021419 
                 1.74E−02 
                 2.19E−02 
                 2.12E−02 
                 1 
                 SMARCB1 
               
               
                 D50918 
                 1.74E−02 
                 5.43E−03 
                 3.23E−03 
                 1 
               
               
                 H65865 
                 1.74E−02 
                 2.72E−02 
                 1.69E−02 
                 1 
                 FLJ13910 
               
               
                 M62324 
                 1.74E−02 
                 5.43E−03 
                 7.50E−03 
                 1 
                 ARID5A 
               
               
                 AW168132 
                 1.74E−02 
                 2.19E−02 
                 3.40E−03 
                 1 
                 KIAA0404 
               
               
                 AA514622 
                 1.74E−02 
                 2.19E−02 
                 3.47E−02 
                 1 
                 POM121 /// 
               
               
                   
                   
                   
                   
                   
                 LOC340318 
               
               
                 AL578583 
                 1.74E−02 
                 5.47E−04 
                 1.21E−03 
                 1 
                 CORT 
               
               
                 AA022949 
                 1.74E−02 
                 2.19E−02 
                 1.18E−02 
                 1 
                 — 
               
               
                 BG485135 
                 1.74E−02 
                 2.72E−02 
                 1.23E−02 
                 1 
                 — 
               
               
                 BG540628 
                 1.74E−02 
                 2.19E−02 
                 1.73E−02 
                 1 
                 — 
               
               
                 BG482805 
                 1.74E−02 
                 2.19E−02 
                 1.53E−02 
                 1 
                 — 
               
               
                 AC007842 
                 1.74E−02 
                 2.19E−02 
                 4.29E−02 
                 1 
                 LOC163131 
               
               
                 BG325734 
                 1.74E−02 
                 2.72E−02 
                 1.53E−02 
                 1 
                 MAPKAPK2 
               
               
                 AW404894 
                 1.74E−02 
                 2.72E−02 
                 1.37E−02 
                 1 
                 — 
               
               
                 W46388 
                 1.74E−02 
                 2.72E−02 
                 1.58E−02 
                 1 
                 SOD2 
               
               
                 AL008730 
                 1.74E−02 
                 4.17E−03 
                 3.33E−03 
                 1 
                 C6orf4 
               
               
                 X58851 
                 1.74E−02 
                 2.19E−02 
                 4.04E−02 
                 1 
                 MYL4 
               
               
                 L14482 
                 1.74E−02 
                 2.19E−02 
                 2.57E−02 
                 1 
                 POU6F1 
               
               
                 AL050332 
                 1.74E−02 
                 2.19E−02 
                 1.57E−03 
                 1 
                 LYPLA2P1 
               
               
                 D84143 
                 1.74E−02 
                 2.19E−02 
                 5.78E−03 
                 1 
                 — 
               
               
                 AJ224869 
                 1.74E−02 
                 2.19E−02 
                 7.85E−03 
                 1 
                 CXCR4 
               
               
                 AL022067 
                 1.74E−02 
                 2.72E−02 
                 2.51E−02 
                 1 
                 PRDM1 
               
               
                 AL512687 
                 1.74E−02 
                 5.43E−03 
                 1.56E−03 
                 1 
                 NOMO2 /// 
               
               
                   
                   
                   
                   
                   
                 NOMO1 /// 
               
               
                   
                   
                   
                   
                   
                 NOMO3 
               
               
                 D84140 
                 1.74E−02 
                 2.19E−02 
                 4.15E−03 
                 1 
                 — 
               
               
                 AF043583 
                 1.74E−02 
                 2.19E−02 
                 1.59E−02 
                 1 
                 — 
               
               
                 AI042030 
                 1.74E−02 
                 5.43E−03 
                 3.57E−03 
                 1 
                 SMC1L1 
               
               
                 NM_005746 
                 1.74E−02 
                 2.72E−02 
                 9.92E−03 
                 1 
                 PBEF1 
               
               
                 NM_005746 
                 1.74E−02 
                 2.72E−02 
                 1.28E−02 
                 1 
                 PBEF1 
               
               
                 AL523965 
                 1.74E−02 
                 2.19E−02 
                 1.86E−02 
                 1 
                 C6orf106 
               
               
                 NM_017874 
                 1.74E−02 
                 2.19E−02 
                 2.42E−03 
                 1 
                 C20orf27 
               
               
                 NM_022452 
                 1.74E−02 
                 5.43E−03 
                 1.14E−02 
                 1 
                 FBS1 
               
               
                 NM_024324 
                 1.74E−02 
                 2.19E−02 
                 2.83E−03 
                 1 
                 — 
               
               
                 NM_024535 
                 1.74E−02 
                 2.19E−02 
                 1.05E−03 
                 1 
                 CORO7 
               
               
                 NM_023948 
                 1.74E−02 
                 2.19E−02 
                 1.92E−02 
                 1 
                 MOSPD3 
               
               
                 NM_022341 
                 1.74E−02 
                 5.43E−03 
                 1.97E−03 
                 1 
                 PDF /// COG8 
               
               
                 NM_016633 
                 1.74E−02 
                 2.19E−02 
                 2.74E−02 
                 1 
                 ERAF 
               
               
                 NM_012447 
                 1.74E−02 
                 2.72E−02 
                 1.41E−02 
                 1 
                 STAG3 
               
               
                 NM_020533 
                 1.74E−02 
                 2.19E−02 
                 4.81E−02 
                 1 
                 MCOLN1 
               
               
                 NM_019891 
                 1.74E−02 
                 2.19E−02 
                 2.86E−02 
                 1 
                 ERO1LB 
               
               
                 NM_018113 
                 1.74E−02 
                 2.19E−02 
                 4.51E−02 
                 1 
                 LIMR 
               
               
                 NM_017774 
                 1.74E−02 
                 5.43E−03 
                 7.44E−03 
                 1 
                 CDKAL1 
               
               
                 NM_024669 
                 1.74E−02 
                 2.72E−02 
                 3.93E−03 
                 1 
                 FLJ11795 
               
               
                 NM_014076 
                 1.74E−02 
                 7.75E−03 
                 7.57E−04 
                 1 
                 GPR97 
               
               
                 N39536 
                 1.74E−02 
                 5.43E−03 
                 1.95E−03 
                 1 
                 NOMO2 /// 
               
               
                   
                   
                   
                   
                   
                 NOMO1 /// 
               
               
                   
                   
                   
                   
                   
                 NOMO3 
               
               
                 L14754 
                 1.74E−02 
                 2.19E−02 
                 2.49E−02 
                 1 
                 IGHMBP2 
               
               
                 Y14330 
                 1.74E−02 
                 2.43E−02 
                 4.44E−03 
                 1 
                 JAG2 
               
               
                 U88964 
                 1.74E−02 
                 2.19E−02 
                 1.28E−02 
                 1 
                 ISG20 
               
               
                 AL096779 
                 1.74E−02 
                 2.72E−02 
                 2.66E−02 
                 1 
                 C22orf4 
               
               
                 AC005954 
                 1.74E−02 
                 4.17E−03 
                 4.12E−03 
                 1 
                 TJP3 
               
               
                 AF022991 
                 1.74E−02 
                 2.72E−02 
                 1.02E−02 
                 1 
                 PER1 
               
               
                 AB002328 
                 1.74E−02 
                 2.72E−02 
                 1.88E−02 
                 1 
                 CABIN1 
               
               
                 AI150117 
                 1.74E−02 
                 2.72E−02 
                 1.52E−02 
                 1 
                 TOPORS 
               
               
                 AI743331 
                 1.74E−02 
                 2.19E−02 
                 7.64E−03 
                 1 
                 C20orf67 
               
               
                 L38487 
                 3.95E−02 
                 3.54E−02 
                 1.21E−02 
                 1 
                 ESRRA 
               
               
                 BC002356 
                 3.95E−02 
                 4.58E−02 
                 8.37E−03 
                 1 
                 NUCB1 
               
               
                 NM_000177 
                 3.95E−02 
                 7.66E−04 
                 3.31E−03 
                 1 
                 GSN 
               
               
                 NM_000018 
                 3.95E−02 
                 4.91E−02 
                 1.50E−02 
                 1 
                 ACADVL 
               
               
                 NM_002332 
                 3.95E−02 
                 3.54E−02 
                 2.62E−02 
                 1 
                 LRP1 
               
               
                 AI920976 
                 3.95E−02 
                 3.54E−02 
                 1.14E−02 
                 1 
                 RERE 
               
               
                 AL523776 
                 3.95E−02 
                 9.26E−03 
                 1.65E−02 
                 1 
                 OTUB1 
               
               
                 NM_003097 
                 3.95E−02 
                 4.91E−02 
                 4.68E−02 
                 1 
                 SNURF /// 
               
               
                   
                   
                   
                   
                   
                 SNRPN 
               
               
                 NM_006295 
                 3.95E−02 
                 7.66E−04 
                 4.08E−03 
                 1 
                 VARS2 
               
               
                 NM_001540 
                 3.95E−02 
                 2.49E−02 
                 2.73E−02 
                 1 
                 HSPB1 
               
               
                 NM_003040 
                 3.95E−02 
                 2.52E−03 
                 5.86E−03 
                 1 
                 SLC4A2 
               
               
                 NM_015049 
                 3.95E−02 
                 3.54E−02 
                 5.05E−03 
                 1 
                 ALS2CR3 
               
               
                 BC005003 
                 3.95E−02 
                 4.91E−02 
                 2.77E−02 
                 1 
                 NFYC 
               
               
                 BC000120 
                 3.95E−02 
                 2.49E−02 
                 1.09E−02 
                 1 
                 GTF2F1 
               
               
                 NM_005334 
                 3.95E−02 
                 3.54E−02 
                 1.79E−02 
                 1 
                 HCFC1 
               
               
                 NM_004216 
                 3.95E−02 
                 3.54E−02 
                 1.04E−02 
                 1 
                 DEDD 
               
               
                 NM_006700 
                 3.95E−02 
                 1.23E−02 
                 8.01E−04 
                 1 
                 FLN29 
               
               
                 NM_004514 
                 3.95E−02 
                 2.49E−02 
                 2.54E−02 
                 1 
                 FOXK2 
               
               
                 NM_005077 
                 3.95E−02 
                 3.54E−02 
                 5.69E−03 
                 1 
                 TLE1 
               
               
                 NM_005641 
                 3.95E−02 
                 4.91E−02 
                 9.70E−03 
                 1 
                 TAF6 
               
               
                 NM_003704 
                 3.95E−02 
                 7.66E−04 
                 3.50E−03 
                 1 
                 C4orf8 
               
               
                 NM_006547 
                 3.95E−02 
                 3.54E−02 
                 2.21E−02 
                 1 
                 IMP-3 
               
               
                 AL136771 
                 3.95E−02 
                 2.32E−02 
                 2.43E−03 
                 1 
                 ELL 
               
               
                 NM_000265 
                 3.95E−02 
                 4.88E−03 
                 2.45E−03 
                 1 
                 NCF1 
               
               
                 NM_002555 
                 3.95E−02 
                 9.26E−03 
                 2.18E−03 
                 1 
                 SLC22A18 
               
               
                 NM_003043 
                 3.95E−02 
                 3.54E−02 
                 2.64E−02 
                 1 
                 SLC6A6 
               
               
                 NM_014813 
                 3.95E−02 
                 1.23E−02 
                 3.47E−03 
                 1 
                 LRIG2 
               
               
                 NM_001157 
                 3.95E−02 
                 4.88E−03 
                 5.60E−03 
                 1 
                 ANXA11 
               
               
                 NM_006865 
                 3.95E−02 
                 4.58E−02 
                 1.11E−02 
                 1 
                 LILRA3 
               
               
                 NM_004258 
                 3.95E−02 
                 7.66E−04 
                 3.58E−02 
                 1 
                 IGSF2 
               
               
                 AF052179 
                 3.95E−02 
                 3.54E−02 
                 3.45E−02 
                 1 
                 ARF1 
               
               
                 BE674658 
                 3.95E−02 
                 2.32E−02 
                 2.24E−02 
                 1 
                 FLJ13052 
               
               
                 BC003381 
                 3.95E−02 
                 3.54E−02 
                 1.54E−03 
                 1 
                 KIAA0217 
               
               
                 K02920 
                 3.95E−02 
                 9.26E−03 
                 7.34E−03 
                 1 
                 GBA 
               
               
                 D87454 
                 3.95E−02 
                 4.91E−02 
                 4.30E−02 
                 1 
                 KIAA0265 
               
               
                 U66879 
                 3.95E−02 
                 1.75E−02 
                 3.88E−03 
                 1 
                 BAD 
               
               
                 AB011179 
                 3.95E−02 
                 2.32E−02 
                 3.44E−03 
                 1 
                 NCDN 
               
               
                 D37781 
                 3.95E−02 
                 4.91E−02 
                 1.33E−02 
                 1 
                 PTPRJ 
               
               
                 U22815 
                 3.95E−02 
                 2.49E−02 
                 2.64E−03 
                 1 
                 PPFIA1 
               
               
                 U81802 
                 3.95E−02 
                 2.49E−02 
                 7.85E−03 
                 1 
                 PIK4CB 
               
               
                 BC004516 
                 3.95E−02 
                 9.26E−03 
                 4.07E−02 
                 1 
                 MAX 
               
               
                 AF056322 
                 3.95E−02 
                 2.49E−02 
                 2.77E−02 
                 1 
                 SP100 
               
               
                 AF234161 
                 3.95E−02 
                 4.91E−02 
                 5.17E−03 
                 1 
                 CIZ1 
               
               
                 U90940 
                 3.95E−02 
                 4.91E−02 
                 4.23E−02 
                 1 
                 FCGR2C 
               
               
                 AL046054 
                 3.95E−02 
                 2.32E−02 
                 1.78E−02 
                 1 
                 PTOV1 
               
               
                 AI762552 
                 3.95E−02 
                 4.91E−02 
                 9.59E−03 
                 1 
                 HNRPDL 
               
               
                 BF974389 
                 3.95E−02 
                 3.54E−02 
                 7.94E−03 
                 1 
                 MTVR1 
               
               
                 AW237172 
                 3.95E−02 
                 2.32E−02 
                 2.21E−02 
                 1 
                 JMJD2B 
               
               
                 AA877910 
                 3.95E−02 
                 1.23E−02 
                 3.15E−03 
                 1 
                 ATP2A3 
               
               
                 AW157619 
                 3.95E−02 
                 9.26E−03 
                 3.57E−03 
                 1 
                 CES2 
               
               
                 AW451236 
                 3.95E−02 
                 2.49E−02 
                 2.11E−02 
                 1 
                 TCEB3 
               
               
                 BE856549 
                 3.95E−02 
                 3.54E−02 
                 4.99E−02 
                 1 
                 KIAA0974 
               
               
                 AW072388 
                 3.95E−02 
                 1.75E−02 
                 4.60E−03 
                 1 
                 NCF1 
               
               
                 AK025604 
                 3.95E−02 
                 3.54E−02 
                 9.44E−03 
                 1 
                 M-RIP 
               
               
                 AL096741 
                 3.95E−02 
                 4.58E−02 
                 5.49E−03 
                 1 
                 ASCC2 
               
               
                 AK025271 
                 3.95E−02 
                 3.54E−02 
                 4.30E−02 
                 1 
                 CHCHD3 
               
               
                 AB035175 
                 3.95E−02 
                 2.32E−02 
                 2.57E−03 
                 1 
                 IGHG1 
               
               
                 NM_016145 
                 3.95E−02 
                 4.91E−02 
                 1.95E−02 
                 1 
                 PTD008 
               
               
                 BE891920 
                 3.95E−02 
                 2.49E−02 
                 4.78E−02 
                 1 
                 ARPC4 
               
               
                 NM_024293 
                 3.95E−02 
                 9.26E−03 
                 3.73E−03 
                 1 
                 C2orf17 
               
               
                 NM_014164 
                 3.95E−02 
                 3.54E−02 
                 1.73E−03 
                 1 
                 FXYD5 
               
               
                 AL561281 
                 3.95E−02 
                 3.54E−02 
                 4.57E−02 
                 1 
                 MAP4K4 
               
               
                 NM_006342 
                 3.95E−02 
                 3.54E−02 
                 3.08E−02 
                 1 
                 TACC3 
               
               
                 NM_017684 
                 3.95E−02 
                 3.54E−02 
                 1.76E−02 
                 1 
                 VPS13C 
               
               
                 NM_022089 
                 3.95E−02 
                 2.32E−02 
                 4.84E−03 
                 1 
                 HSA9947 
               
               
                 NM_018053 
                 3.95E−02 
                 2.49E−02 
                 2.04E−02 
                 1 
                 FLJ10307 
               
               
                 NM_024604 
                 3.95E−02 
                 4.91E−02 
                 3.07E−02 
                 1 
                 FLJ21908 
               
               
                 NM_018694 
                 3.95E−02 
                 3.54E−02 
                 4.96E−02 
                 1 
                 ARL6IP4 
               
               
                 NM_019096 
                 3.95E−02 
                 4.58E−02 
                 6.10E−03 
                 1 
                 GTPBP2 
               
               
                 AB016531 
                 3.95E−02 
                 2.52E−03 
                 1.67E−02 
                 1 
                 PEX16 
               
               
                 AI660075 
                 3.95E−02 
                 3.54E−02 
                 3.63E−02 
                 1 
                 LRCH4 
               
               
                 AF052151 
                 3.95E−02 
                 4.88E−03 
                 7.99E−03 
                 1 
                 MTVR1 
               
               
                 AI744083 
                 3.95E−02 
                 3.54E−02 
                 6.98E−03 
                 1 
                 MOSPD2 
               
               
                   
               
               
                 Table 4: Provided are genetic markers which are differentially expressed between subjects diagnosed with definite multiple sclerosis and healthy controls (the Probeset ID of the Affymetrix Gene Chip), along with the corresponding GenBank accession number (GenBank Acc. No.), the gene symbol and the direction (Dir) of change in gene expression (“1” - upregulation; “−1” - downregulation). 
               
               
                 Note that the p values of the TNOM, Info and t-Test statistical tests all passed the 95% confidence level. 
               
            
           
         
       
     
     Example 3 
     Identification of Genes which Expression Pattern is Characteristics to Probable Multiple Sclerosis Subjects which Further Convert to Definite Multiple Sclerosis 
     Probable vs. definite gene expression patterns—To identify genes which expression pattern, i.e., upregulation or downregulation is characteristics to probable multiple sclerosis subjects who further convert to definite multiple sclerosis (within a 2 years period), the PBMC expression pattern of genes differentially expressed between definite RRMS/healthy controls (722 genetic markers shown in Table 4, hereinabove) was compared to the expression pattern of probable MS who converted to definite MS (12 patients, converted within 2-years)/healthy controls (1517 genetic markers shown in Table 2, hereinabove). 
     This intersection disclosed 58 universal genes that characterize probable (who are predisposed to develop definite MS) and definite MS disease ( FIG. 3  and Table 5, hereinbelow). This signature included MMP genes: MMP9, MMP14; antigen presenting genes like: B7-1 (CD80, CD28); T-cells receptor genes and neuron survival genes: SIP1, TCRγV. 
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 Universal expression pattern of markers common to subjects with 
               
               
                 probable MS diagnosis which later converted to definite diagnosis 
               
               
                 of MS and subjects with definite diagnosis of MS 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 SEQ 
                   
                   
                   
                   
               
               
                   
                 ID 
                 GenBank 
                   
                 Fold 
               
               
                 Probeset 
                 NO: 
                 Accession No. 
                 Dir 
                 Change 
                 Gene Symbol 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 203335_at 
                 1 
                 NM_006214 
                 −1 
                 2.0 
                 PHYH 
               
               
                 216746_at 
                 2 
                 AK024606 
                 −1 
                 2.1 
                 AK024606 
               
               
                 217377_x_at 
                 3 
                 AF041811 
                 −1 
                 2.3 
                 NTRK3 
               
               
                 214274_s_at 
                 4 
                 AI860341 
                 −1 
                 2.4 
                 ACAA1 
               
               
                 204151_x_at 
                 5 
                 NM_001353 
                 −1 
                 2.6 
                 AKR1C1 
               
               
                 203468_at 
                 6 
                 NM_003674 
                 −1 
                 2.9 
                 CDK10 
               
               
                 218303_x_at 
                 7 
                 NM_016618 
                 −1 
                 2.9 
                 LOC51315 
               
               
                 204221_x_at 
                 8 
                 U16307 
                 −1 
                 2.9 
                 HRB2 
               
               
                 218129_s_at 
                 9 
                 BC005316 
                 −1 
                 3.1 
                 NFYB 
               
               
                 212073_at 
                 10 
                 AI631874 
                 −1 
                 3.2 
                 CSNK2A1 
               
               
                 218607_s_at 
                 11 
                 NM_018115 
                 −1 
                 3.2 
                 SDAD1 
               
               
                 206271_at 
                 12 
                 NM_003265 
                 −1 
                 3.4 
                 TLR3 
               
               
                 217908_s_at 
                 13 
                 NM_018442 
                 −1 
                 3.5 
                 IQWD1 
               
               
                 160020_at 
                 14 
                 Z48481 
                 −1 
                 3.7 
                 MMP14 
               
               
                 217381_s_at 
                 15 
                 X69383 
                 −1 
                 4.1 
                 TCR 
               
               
                 218349_s_at 
                 16 
                 AA824298 
                 −1 
                 4.8 
                 FLJ10036 
               
               
                 221007_s_at 
                 17 
                 NM_030917 
                 −1 
                 5.0 
                 FIP1L1 
               
               
                 218728_s_at 
                 18 
                 AK024569 
                 −1 
                 5.7 
                 HSPC163 
               
               
                 218096_at 
                 19 
                 NM_018361 
                 −1 
                 6.2 
                 LPAAT-e 
               
               
                 213980_s_at 
                 20 
                 AA053830 
                 −1 
                 6.4 
                 CTBP1 
               
               
                 222149_x_at 
                 21 
                 AL137398 
                 −1 
                 6.6 
                 DKFZp434P162 
               
               
                 221222_s_at 
                 22 
                 NM_017860 
                 −1 
                 6.8 
                 FLJ20519 
               
               
                 202660_at 
                 23 
                 AA834576 
                 −1 
                 8.1 
                 ITPR2 
               
               
                 210235_s_at 
                 24 
                 U22815 
                 −1 
                 8.3 
                 PPFIA1 
               
               
                 205540_s_at 
                 25 
                 NM_016656 
                 −1 
                 8.8 
                 RRAGB 
               
               
                 204682_at 
                 26 
                 NM_000428 
                 −1 
                 9.0 
                 LTBP2 
               
               
                 218859_s_at 
                 27 
                 NM_016649 
                 −1 
                 12.2 
                 C20orf6 
               
               
                 218699_at 
                 28 
                 NM_003929 
                 −1 
                 26.5 
                 RAB7L1 
               
               
                 205063_at 
                 29 
                 NM_003616 
                 −1 
                 31.3 
                 SIP1 
               
               
                 214085_x_at 
                 30 
                 AI912583 
                 −1 
                 66.8 
                 HRB2 
               
               
                 216399_s_at 
                 31 
                 AK025663 
                 −1 
                 82.9 
                 ZNF291 
               
               
                 219575_s_at 
                 32 
                 NM_022341 
                 1 
                 2.0 
                 PDF, COG8 
               
               
                 216330_s_at 
                 33 
                 L14482 
                 1 
                 2.1 
                 POU6F1 
               
               
                 203222_s_at 
                 34 
                 NM_005077 
                 1 
                 2.1 
                 TLE1 
               
               
                 203064_s_at 
                 35 
                 NM_004514 
                 1 
                 2.2 
                 FOXK2 
               
               
                 207176_s_at 
                 36 
                 NM_005191 
                 1 
                 2.2 
                 CD80 
               
               
                 213360_s_at 
                 37 
                 AA514622 
                 1 
                 2.2 
                 POM121 
               
               
                 205920_at 
                 38 
                 NM_003043 
                 1 
                 2.4 
                 SLC6A6 
               
               
                 206544_x_at 
                 39 
                 NM_003070 
                 1 
                 2.4 
                 SMARCA2 
               
               
                 218961_s_at 
                 40 
                 NM_007254 
                 1 
                 2.7 
                 PNKP 
               
               
                 201526_at 
                 41 
                 NM_001662 
                 1 
                 2.9 
                 ARF5 
               
               
                 203936_s_at 
                 42 
                 NM_004994 
                 1 
                 3.0 
                 MMP9 
               
               
                 207908_at 
                 43 
                 NM_000423 
                 1 
                 3.1 
                 KRT2A 
               
               
                 202942_at 
                 44 
                 NM_001985 
                 1 
                 3.3 
                 ETFB 
               
               
                 211696_x_at 
                 45 
                 AF349114 
                 1 
                 4.3 
                 HBB 
               
               
                 218037_at 
                 46 
                 NM_024293 
                 1 
                 4.9 
                 C2orf17 
               
               
                 209116_x_at 
                 47 
                 M25079 
                 1 
                 5.3 
                 HBB 
               
               
                 204018_x_at 
                 48 
                 NM_000558 
                 1 
                 6.4 
                 HBA1, HBA2 
               
               
                 200055_at 
                 49 
                 NM_006284 
                 1 
                 6.5 
                 TAF10 
               
               
                 202596_at 
                 50 
                 BC000436 
                 1 
                 6.6 
                 ENSA 
               
               
                 201827_at 
                 51 
                 AF113019 
                 1 
                 7.2 
                 SMARCD2 
               
               
                 214414_x_at 
                 52 
                 T50399 
                 1 
                 7.6 
                 HBA2 
               
               
                 202768_at 
                 53 
                 NM_006732 
                 1 
                 14.0 
                 FOSB 
               
               
                 215684_s_at 
                 54 
                 AL096741 
                 1 
                 14.9 
                 ASCC2 
               
               
                 212071_s_at 
                 55 
                 BE968833 
                 1 
                 21.8 
                 SPTBN1 
               
               
                 202111_at 
                 56 
                 NM_003040 
                 1 
                 28.8 
                 SLC4A2 
               
               
                 212413_at 
                 57 
                 D50918 
                 1 
                 105.1 
                 D50918 
               
               
                 209740_s_at 
                 58 
                 U03886 
                 1 
                 106.7 
                 PNPLA4 
               
               
                   
               
               
                 Table 5: Genetic markers which are differentially expressed between probable multiple sclerosis which further developed definite diagnosis of MS and healthy controls are provided (the Probeset ID of the Affymetrix Gene Chip), along with the corresponding GenBank accession number, the gene symbol, the SEQ ID NO., the direction of change in gene expression (“1”- upregulation; “−1” - downregulation) and the fold change in subjects diagnosed with probable MS (who are predisposed to develop definite MS) as compared to healthy control (probable MS/healthy control). 
               
               
                 Note that the p values of the TNOM, Info and t-Test statistical tests all passed the 95% confidence level. 
               
            
           
         
       
     
     Determination of the prediction power of selected genes which differentiate between probable MS subjects who are predisposed to develop definite MS and healthy controls—To evaluate the power of each of the 58 differentiating genes (SEQ ID NOs:1-58) identified in this study to predict the predisposition of a probable MS subject to develop a definite MS diagnosis, the study sample of 40 probable patients was randomly divided into 80% of the subjects as a “training set” and 20% (to confirm) of the subjects as a “test set” and a model was build using the SVM based on RBF kernel. For each of the differentiating genes the predictability of the training set on the test set was computed and the average error following 25 permutations was calculated. Genes with the lowest average error were selected, then, for each selected gene, the remaining genes were added one after the other, by selecting the next gene such that the average error after 25 repeats of the group of genes including the new gene has the lowest average error as compared to the addition of another gene. This process was repeated 57 times for each additional gene added to the previous group of genes. The resulting average error for each gene combination is depicted in Table 6, hereinbelow, wherein the first gene in row number 1 (SEQ ID NO:4) exhibits the best predictive power (error average of “0.21”) as a single gene. 
     
       
         
           
               
               
               
               
               
               
             
               
                 TABLE 6 
               
               
                   
               
               
                 Row 
                 SEQ 
                   
                   
                   
                   
               
               
                 Num- 
                 ID 
                   
                 Gene Bank 
                 Error 
                 Gene 
               
               
                 ber 
                 NO: 
                 Probeset ID 
                 ID 
                 Average 
                 Symbol 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1 
                 4 
                 214274_s_at 
                 AI860341 
                 0.216363636 
                 ACAA1 
               
               
                 2 
                 16 
                 218349_s_at 
                 NM_017975 
                 0.216363636 
                 FLJ10036 
               
               
                 3 
                 5 
                 204151_x_at 
                 NM_001353 
                 0.247272727 
                 AKR1C1 
               
               
                 4 
                 56 
                 202111_at 
                 NM_003040 
                 0.230909091 
                 SLC4A2 
               
               
                 5 
                 20 
                 213980_s_at 
                 AA053830 
                 0.223636364 
                 CTBP1 
               
               
                 6 
                 3 
                 217377_x_at 
                 AF041811 
                 0.158181818 
                 NTRK3 
               
               
                 7 
                 1 
                 203335_at 
                 NM_006214 
                 0.169090909 
                 PHYH 
               
               
                 8 
                 10 
                 212073_at 
                 AI631874 
                 0.176363636 
                 CSNK2A1 
               
               
                 9 
                 57 
                 212413_at 
                 D50918 
                 0.169090909 
                 6-Sep 
               
               
                 10 
                 24 
                 210235_s_at 
                 U22815 
                 0.194545455 
                 PPFIA1 
               
               
                 11 
                 14 
                 160020_at 
                 Z48481 
                 0.214545455 
                 MMP14 
               
               
                 12 
                 49 
                 200055_at 
                 NM_006284 
                 0.201818182 
                 TAF10 
               
               
                 13 
                 13 
                 217908_s_at 
                 NM_018442 
                 0.181818182 
                 PC326 
               
               
                 14 
                 37 
                 213360_s_at 
                 AA514622 
                 0.163636364 
                 na 
               
               
                 15 
                 6 
                 203468_at 
                 NM_003674 
                 0.165454545 
                 CDK10 
               
               
                 16 
                 47 
                 209116_x_at 
                 M25079 
                 0.158181818 
                 HBB 
               
               
                 17 
                 50 
                 202596_at 
                 BC000436 
                 0.163636364 
                 ENSA 
               
               
                 18 
                 21 
                 222149_x_at 
                 AL137398 
                 0.154545455 
                 — 
               
               
                 19 
                 46 
                 218037_at 
                 NM_024293 
                 0.143636364 
                 MGC3035 
               
               
                 20 
                 8 
                 204221_x_at 
                 U16307 
                 0.165454545 
                 GLIPR1 
               
               
                 21 
                 26 
                 204682_at 
                 NM_000428 
                 0.174545455 
                 LTBP2 
               
               
                 22 
                 2 
                 216746_at 
                 AK024606 
                 0.169090909 
                 — 
               
               
                 23 
                 15 
                 217381_s_at 
                 X69383 
                 0.172727273 
                 — 
               
               
                 24 
                 51 
                 201827_at 
                 AF113019 
                 0.167272727 
                 SMARCD2 
               
               
                 25 
                 44 
                 202942_at 
                 NM_001985 
                 0.170909091 
                 ETFB 
               
               
                 26 
                 19 
                 218096_at 
                 NM_018361 
                 0.167272727 
                 LPAAT-e 
               
               
                 27 
                 17 
                 221007_s_at 
                 NM_030917 
                 0.176363636 
                 FIP1L1 
               
               
                 28 
                 25 
                 205540_s_at 
                 NM_016656 
                 0.176363636 
                 RRAGB 
               
               
                 29 
                 33 
                 216330_s_at 
                 L14482 
                 0.161818182 
                 POU6F1 
               
               
                 30 
                 48 
                 204018_x_at 
                 NM_000558 
                 0.174545455 
                 HBA1 
               
               
                 31 
                 36 
                 207176_s_at 
                 NM_005191 
                 0.161818182 
                 CD80 
               
               
                 32 
                 34 
                 203222_s_at 
                 NM_005077 
                 0.158181818 
                 TLE1 
               
               
                 33 
                 12 
                 206271_at 
                 NM_003265 
                 0.132727273 
                 TLR3 
               
               
                 34 
                 29 
                 205063_at 
                 NM_003616 
                 0.136363636 
                 SIP1 
               
               
                 35 
                 23 
                 202660_at 
                 AA834576 
                 0.132727273 
                 — 
               
               
                 36 
                 11 
                 218607_s_at 
                 NM_018115 
                 0.150909091 
                 FLJ10498 
               
               
                 37 
                 45 
                 211696_x_at 
                 AF349114 
                 0.149090909 
                 HBB 
               
               
                 38 
                 53 
                 202768_at 
                 NM_006732 
                 0.16 
                 FOSB 
               
               
                 39 
                 41 
                 201526_at 
                 NM_001662 
                 0.156363636 
                 ARF5 
               
               
                 40 
                 40 
                 218961_s_at 
                 NM_007254 
                 0.130909091 
                 PNKP 
               
               
                 41 
                 31 
                 216399_s_at 
                 AK025663 
                 0.154545455 
                 ZNF291 
               
               
                 42 
                 58 
                 209740_s_at 
                 U03886 
                 0.143636364 
                 DXS1283E 
               
               
                 43 
                 27 
                 218859_s_at 
                 NM_016649 
                 0.147272727 
                 C20orf6 
               
               
                 44 
                 43 
                 207908_at 
                 NM_000423 
                 0.132727273 
                 KRT2A 
               
               
                 45 
                 35 
                 203064_s_at 
                 NM_004514 
                 0.132727273 
                 ILF1 
               
               
                 46 
                 30 
                 214085_x_at 
                 AI912583 
                 0.16 
                 HRB2 
               
               
                 47 
                 52 
                 214414_x_at 
                 T50399 
                 0.156363636 
                 HBA1 
               
               
                 48 
                 55 
                 212071_s_at 
                 BE968833 
                 0.147272727 
                 SPTBN1 
               
               
                 49 
                 7 
                 218303_x_at 
                 NM_016618 
                 0.16 
                 LOC51315 
               
               
                 50 
                 9 
                 218129_s_at 
                 NM_006166 
                 0.161818182 
                 NFYB 
               
               
                 51 
                 42 
                 203936_s_at 
                 NM_004994 
                 0.167272727 
                 MMP9 
               
               
                 52 
                 28 
                 218699_at 
                 BG338251 
                 0.145454545 
                 RAB7L1 
               
               
                 53 
                 54 
                 215684_s_at 
                 AL096741 
                 0.170909091 
                 FLJ21588 
               
               
                 54 
                 32 
                 219575_s_at 
                 NM_022341 
                 0.167272727 
                 COG8 
               
               
                 55 
                 22 
                 221222_s_at 
                 NM_017860 
                 0.178181818 
                 FLJ20519 
               
               
                 56 
                 18 
                 218728_s_at 
                 NM_014184 
                 0.181818182 
                 HSPC163 
               
               
                 57 
                 38 
                 205920_at 
                 NM_003043 
                 0.190909091 
                 SLC6A6 
               
               
                 58 
                 39 
                 206544_x_at 
                 NM_003070 
                 0.194545455 
                 SMARCA2 
               
               
                   
               
               
                 Table 6: Shown are the average errors of predicting a probability of a probable MS subject to develop the diagnosis of definite MS within a 2-years period based on a model computed for each gene or a group of genes in the MS training set group. The ascending order of genes reflects combinations of genes, where each row includes the gene specified in that row and in all preceding rows. For example, the average error presented in row number 4 reflects the average error in predicting a probability of a probable MS subject to develop the diagnosis of definite MS within a 2-years period using the group of genes described in rows 1, 2, 3 and 4 (i.e., SEQ ID NOs: 4, 16, 5 and 56). 
               
               
                 Probe set ID = Affymetrix ID. 
               
            
           
         
       
     
     As shown in Table 6 hereinabove, the predictive power of each set of genes was evaluated using the MS training and test sets of samples. The polynucleotide exhibiting the best predictive power in determining the probability of a probable MS subject to convert to the diagnosis of definite MS was the polynucleotide set forth by SEQ ID NO:4 (GenBank Accession No. AI860341; row No. 1 in Table 6), in which the average error between the test and training groups was 0.216. Similarly, the combination genes set forth by SEQ ID NOs:4 and 16 (GenBank Accession No. NM — 017975; row No. 2 in Table 6) displayed a predictive power with 0.216 average error. Another exemplary combination, which provides an even higher prediction power (with a smaller average error) is shown in row number 6 in Table 6, in which the combination of the polynucleotide sequences set forth in SEQ ID NOs:4, 16, 5, 56, 20 and 3 displayed a high predictive power with 0.158 average error. Yet another exemplary combination, which provides an even higher prediction power (with a smaller average error) is shown in row number 35 in Table 6, in which the combination of the polynucleotide sequences set forth in SEQ ID NOs:4, 16, 5, 56, 20, 3, 1, 10, 57, 24, 14, 49, 13, 37, 6, 47, 50, 21, 46, 8, 26, 2, 15, 51, 44, 19, 17, 25, 33, 48, 36, 34, 12, 29 and 23 displayed a high predictive power with 0.132 average error. Thus, this analysis enables one skilled in the art to select a group of polynucleotides which can give the best predictive power for prediction of the probability of a subject diagnosed with probable MS (after the first neurological attack) to develop the diagnosis of definite MS within 2 years. 
     CONCLUSIONS 
     1. PBMC gene expression signature distinguished probable MS patients from healthy subjects. 
     2. Patients that experience a second relapse and converted to definite MS during 2 years of follow-up period have a specific gene expression signature. 
     3. Patients with probable and definite MS demonstrate a universal gene expression signature. 
     It is appreciated that certain features of the invention, which are, for clarity, described in the context of separate embodiments, may also be provided in combination in a single embodiment. Conversely, various features of the invention, which are, for brevity, described in the context of a single embodiment, may also be provided separately or in any suitable subcombination. 
     Although the invention has been described in conjunction with specific embodiments thereof, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art. Accordingly, it is intended to embrace all such alternatives, modifications and variations that fall within the spirit and broad scope of the appended claims. All publications, patents and patent applications mentioned in this specification are herein incorporated in their entirety by reference into the specification, to the same extent as if each individual publication, patent or patent application was specifically and individually indicated to be incorporated herein by reference. In addition, citation or identification of any reference in this application shall not be construed as an admission that such reference is available as prior art to the present invention. 
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     Additional References are Cited in Text 
     
         
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