Patent Publication Number: US-2023157290-A1

Title: Alkene-containing carboxylate compound and use thereof

Description:
TECHNICAL FIELD 
     The present invention belongs to the field of herbicides, and particularly relates to an alkene-containing carboxylic ester compound and an application thereof. 
     BACKGROUND 
     Due to the succession and change of weed populations and the emergence and rapid development of resistance to chemical pesticides, people have continuously strengthened awareness on ecological environmental protection, and have paid more attention to the knowledge of chemical pesticide pollution and the influence of pesticides on non-target organisms and the end-result problem in the pesticide ecological environment. With the gradual decrease of the arable land area in the world, the continuous increase of the population and the increase of the demands for food, people are forced to rapidly develop agricultural production technologies, enhance and improve the farming system, and continuously invent novel and improved herbicidal compounds and compositions. 
     DE 2513750A1 has reported that some benzoyl pyrazole compounds have herbicidal activity, such as compound 79 (KC 1 ): 
     
       
         
         
             
             
         
       
     
     WO 0003993A1 has reported that some benzoyl pyrazole compounds have herbicidal activity, such as compound 357 (KC 2 ): 
     
       
         
         
             
             
         
       
     
     The alkene-containing carboxylic ester compound shown in the present invention is not disclosed. 
     SUMMARY 
     The purpose of the present invention is to provide an alkene-containing carboxylic ester compound with novel structure and safety for crops and an application thereof as a herbicide. 
     To achieve the above purpose, the present invention adopts the following technical solution: An alkene-containing carboxylic ester compound is shown in formula I: 
     
       
         
         
             
             
         
       
     
     in the formula: 
     X 1  is selected from hydrogen, cyano, nitro, halogen, C 1 -C 6  alkylsulfonyl, C 1 -C 6  haloalkylsulfonyl, C 1 -C 6  alkylsulfinyl, C 1 -C 6  haloalkylsulfinyl, C 1 -C 6  alkylthio, C 1 -C 6  haloalkylthio, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  alkoxy C 1 -C 3  alkyl, C 1 -C 6  alkoxy C 1 -C 3  alkoxy, C 1 -C 6  alkoxy C 1 -C 3  alkoxy C 1 -C 3  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl C 1 -C 3  alkyl, C 3 -C 6  cycloalkyl C 1 -C 3  alkoxy, C 3 -C 6  cycloalkyloxy, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, phenyl, C 2 -C 6  alkenylsulfonyl, C 2 -C 6  alkynylsulfonyl, phenylsulfonyl, C 2 -C 6  alkenyloxy, C 2 -C 6  alkynyloxy, phenyloxy, C 2 -C 6  alkenylthio, C 2 -C 6  alkynylthio, phenylthio, 5-7 membered aliphatic heterocycle containing 1-4 heteroatoms, 5-7 membered aromatic heterocycle containing 1-4 heteroatoms, 5-7 membered aliphatic heterocyclic C 1 -C 6  alkyl containing 1-4 heteroatoms or 5-7 membered aromatic heterocyclic C 1 -C 6  alkyl containing 1-4 heteroatoms; hydrogen on the phenyl, the aliphatic heterocycle and the aromatic heterocycle mentioned above may be substituted by one or more of the following substituents which are selected from nitro, halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy or C 3 -C 6  cycloalkyl; 
     W is selected from N or CX 2 ; 
     X 2  is selected from hydrogen, cyano, nitro, halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl C 1 -C 6  alkyl, C 3 -C 6  halocycloalkyl C 1 -C 6  alkyl, Y 1  oxy, Y 1  thio, Y 1 Y 2  amino, Y 1  sulfinyl, Y 1  sulfonyl, Y 1  oxy C 1 -C 6  alkyl, Y 1  thio C 1 -C 6  alkyl, YjY2 amino C 1 -C 6  alkyl, Y 1  sulfinyl C 1 -C 6  alkyl, Y 1  sulfonyl C 1 -C 6  alkyl, C(O)Y 1 , C(O)OY 1 , OC(O)OY 1 , N(Y 1 )C(O)OY 2 , C(O)N(Y 1 )Y 2 , N(Y 1 )C(O)N(Y 1 )Y 2 , OC(O)N(Y 1 )Y 2 , C(O)N(Y 1 )OY 2 , N(Y 1 )S(O) 2 Y 2 , N(Y 1 )C(O)Y 2 , OS(O) 2 Y 1 , CH═NOY 1 , C 1 -C 6  alkyl-CH═NOY 1 , C 1 -C 6  alkyl-O—N═C(Y 1 )Y 2 , phenyl, 5-7 membered alicyclic heterocycle containing 1-4 heteroatoms, 5-7 membered aromatic heterocycle containing 1-4 heteroatoms, 5-7 membered aliphatic heterocyclic C 1 -C 6  alkyl containing 1-4 heteroatoms or 5-7 membered aromatic heterocyclic C 1 -C 6  alkyl containing 1-4 heteroatoms; the hydrogen on the phenyl, the aliphatic heterocycle and the aromatic heterocycle mentioned above may be substituted by one or more of the following substituents which are selected from nitro, halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkoxy, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, phenyl or halophenyl; 
     Y 1  and Y 2  are independently selected from C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl C 1 -C 6  alkyl, C 1 -C 6  alkoxy C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, phenyl, 5-7 membered aliphatic heterocycle containing 1-4 heteroatoms, 5-7 membered aromatic heterocycle containing 1-4 heteroatoms, 5-7 membered aliphatic heterocyclic C 1 -C 6  alkyl containing 1-4 heteroatoms or 5-7 membered aromatic heterocyclic C 1 -C 6  alkyl containing 1-4 heteroatoms; the hydrogen on the phenyl, the aliphatic heterocycle and the aromatic heterocycle mentioned above may be substituted by one or more of the following substituents which are selected from nitro, halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkoxy, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, phenyl or halophenyl; 
     X 3  is selected from hydrogen, cyano, nitro, halogen, C 1 -C 6  alkylsulfonyl, C 1 -C 6  haloalkylsulfonyl, C 1 -C 6  alkylsulfinyl, C 1 -C 6  haloalkylsulfinyl, C 1 -C 6  alkylthio, C 1 -C 6  haloalkylthio, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  alkoxy C 1 -C 3  alkyl, C 1 -C 6  alkoxy C 1 -C 3  alkoxy, C 1 -C 6  alkoxy C 1 -C 3  alkoxy C 1 -C 3  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl C 1 -C 3  alkyl, C 3 -C 6  cycloalkyl C 1 -C 3  alkoxy, C 3 -C 6  cycloalkyloxy, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 2 -C 6  alkenylsulfonyl, C 2 -C 6  alkynylsulfonyl, C 2 -C 6  alkenyloxy, C 2 -C 6  alkynyloxy, C 2 -C 6  alkenylthio, C 2 -C 6  alkynylthio, phenyl, phenyloxy, phenylthio, phenylsulfonyl, 5-7 membered alicyclic heterocycle containing 1-4 heteroatoms, 5-7 membered aromatic heterocycle containing 1-4 heteroatoms, 5-7 membered alicyclic heterocyclic C 1 -C 6  alkyl containing 1-4 heteroatoms or 5-7 membered aromatic heterocyclic C 1 -C 6  alkyl containing 1-4 heteroatoms; hydrogen on the phenyl, aliphatic heterocycle and aromatic heterocycle mentioned above may be substituted with one or more of the following substituents selected from nitro, halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy or C 3 -C 6  cycloalkyl;
         when X 1  is selected from chlorine and X 3  is selected from methylsulfonyl, X 2  is not 2-thiazolyl;       

     Z 1  is selected from C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl C 1 -C 6  alkyl, C 3 -C 6  alkenyl, C 3 -C 6  alkynyl, C 1 -C 6  alkylsulfonyl C 1 -C 6  alkyl or phenyl; 
     Z 2  is selected from H, C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 6  haloalkyl or phenyl; hydrogen on the phenyl mentioned above can be substituted by one or more of the following substituents; and the substituents are selected from halogen, cyano, nitro, C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl or C 1 -C 6  haloalkyl; 
     Q is selected from Q 1  or Q 2  group; 
     
       
         
         
             
             
         
       
     
     Q 2  is selected from C 3 -C 8  cycloalkenyl; the hydrogen on the ring can be substituted by the following substituents; the following substituents are selected from nitro, halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  alkenyl or C 3 -C 6  cycloalkyl; 
     when Q is selected from Q 2 , Z 2  is not cyclopropyl; 
     R 1  to R 5  are independently selected from hydrogen, cyano, nitro, halogen, phenyl, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 2 -C 6  alkenyl, C 2 -C 6  haloalkenyl, C 2 -C 6  alkynyl, C 2 -C 6  haloalkynyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  alkylthio or benzyloxy; 
     wherein R 1  and R 2  form a benzene ring, a 5-7 membered aliphatic heterocycle containing 1-3 heteroatoms or a 5-7 membered aromatic heterocycle containing 1-3 heteroatoms together with the carbon atoms on the connected benzene ring; 
     R 2  and R 3  can form a benzene ring, a 5-7 membered aliphatic heterocycle containing 1-3 heteroatoms or a 5-7 membered aromatic heterocycle containing 1-3 heteroatoms together with the carbon atoms on the connected benzene ring; 
     a stereoisomer of the compound of the above formula I; or, the compound of the formula I and agriculturally acceptable salt of the isomer. 
     A preferred compound is: in the formula I: 
     X 1  is selected from hydrogen, cyano, nitro, halogen, C 1 -C 6  alkylsulfonyl, C 1 -C 6  alkylsulfinyl, C 1 -C 6  alkylthio, C 1 -C 6  haloalkylthio, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  alkoxy C 1 -C 3  alkyl, C 1 -C 6  alkoxy C 1 -C 3  alkoxy, C 1 -C 6  alkoxy C 1 -C 3  alkoxy C 1 -C 3  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl C 1 -C 3  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 3  alkoxy, C 3 -C 6  cycloalkyloxy, C 2 -C 6  alkenyloxy, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, phenyl, phenylsulfonyl, phenyloxy, a 5-7 membered aliphatic heterocycle containing 1-4 heteroatoms and a 5-7 membered aromatic heterocycle containing 1-4 heteroatoms; the hydrogen on the phenyl, the aliphatic heterocycle and the aromatic heterocycle mentioned above may be substituted by one or more of the following substituents which are selected from nitro, halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy or C 3 -C 6  cycloalkyl; 
     W is selected from N or CX 2 ; 
     X 2  is selected from hydrogen, cyano, nitro, halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl C 1 -C 6  alkyl, C 3 -C 6  halocycloalkyl C 1 -C 6  alkyl, Y 1  oxy, Y 1  thio, Y 1 Y 2  amino, Y 1  sulfinyl, Y 1  sulfonyl, Y 1  oxy C 1 -C 6  alkyl, Y 1  thio C 1 -C 6  alkyl, Y 1 Y 2  amino C 1 -C 6  alkyl, Y 1  sulfinyl C 1 -C 6  alkyl, Y 1  sulfonyl C 1 -C 6  alkyl, C(O)Y 1 , C(O)OY 1 , OC(O)OY 1 , N(Y 1 )C(O)OY 2 , C(O)N(Y 1 )Y 2 , N(Y 1 )C(O)N(Y 1 )Y 2 , OC(O)N(Y 1 )Y 2 , C(O)N(Y 1 )OY 2 , N(Y 1 )S(O) 2 Y 2 , N(Y 1 )C(O)Y 2 , OS(O) 2 Y 1 , CH═NOY 1 , C 1 -C 6  alkyl-CH═NOY 1 , C 1 -C 6  alkyl-O—N═C(Y 1 )Y 2 , phenyl, 5-7 membered alicyclic heterocycle containing 1-4 heteroatoms, 5-7 membered aromatic heterocycle containing 1-4 heteroatoms, 5-7 membered aliphatic heterocyclic C 1 -C 6  alkyl containing 1-4 heteroatoms or 5-7 membered aromatic heterocyclic C 1 -C 6  alkyl containing 1-4 heteroatoms; the hydrogen on the phenyl, the aliphatic heterocycle and the aromatic heterocycle mentioned above may be substituted by one or more of the following substituents which are selected from nitro, halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 3 -C 6  cycloalkyl or C 3 -C 6  cycloalkoxy; 
     Y 1  and Y 2  are independently selected from C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl C 1 -C 6  alkyl, C 1 -C 6  alkoxy C 1 -C 6  alkyl, phenyl, a 5-7 membered aliphatic heterocycle containing 1-4 heteroatoms, a 5-7 membered aromatic heterocycle containing 1-4 heteroatoms, a 5-7 membered aliphatic heterocyclic C 1 -C 6  alkyl containing 1-4 heteroatoms or a 5-7 membered aromatic heterocyclic C 1 -C 6  alkyl containing 1-4 heteroatoms; the hydrogen on the phenyl, the aliphatic heterocycle and the aromatic heterocycle mentioned above may be substituted by one or more of the following substituents which are selected from nitro, halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 3 -C 6  cycloalkyl or C 3 -C 6  cycloalkoxy; 
     X 3  is selected from hydrogen, cyano, halogen, C 1 -C 6  alkylsulfonyl, C 1 -C 6  alkylsulfinyl, C 1 -C 6  alkylthio, C 1 -C 6  haloalkylthio, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  alkoxy C 1 -C 3  alkyl, C 1 -C 6  alkoxy C 1 -C 3  alkoxy, C 1 -C 6  alkoxy C 1 -C 3  alkoxy C 1 -C 3  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl C 1 -C 3  alkyl, C 3 -C 6  cycloalkyl, C 1 -C 3  alkoxy, C 3 -C 6  cycloalkyloxy, C 2 -C 6  alkenyloxy, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, phenyl, phenylsulfonyl, phenyloxy, a 5-7 membered aliphatic heterocycle containing 1-4 heteroatoms and a 5-7 membered aromatic heterocycle containing 1-4 heteroatoms; the hydrogen on the phenyl, the aliphatic heterocycle and the aromatic heterocycle mentioned above may be substituted by one or more of the following substituents which are selected from nitro, halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy or C 3 -C 6  cycloalkyl; 
     when X 1  is selected from chlorine and X 3  is selected from methylsulfonyl, X 2  is not 2-thiazolyl; 
     Z 1  is selected from C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl C 1 -C 6  alkyl, C 3 -C 6  alkenyl, C 3 -C 6  alkynyl or phenyl; 
     Z 2  is selected from H, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl or phenyl; hydrogen on the phenyl mentioned above can be substituted by one or more of the following substituents; and the substituents are selected from halogen, cyano, nitro, C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl or C 1 -C 6  haloalkyl; 
     Q is selected from Q 1  or Q 2  group; 
     
       
         
         
             
             
         
       
     
     Q 2  is selected from C 3 -C 8  cycloalkenyl; the hydrogen on the ring can be substituted by the following substituents; the following substituents are selected from nitro, halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 1 -C 6  alkenyl or C 3 -C 6  cycloalkyl; R 1  to R 5  are independently selected from hydrogen, cyano, nitro, halogen, phenyl, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxy, C 1 -C 6  alkylthio or benzyloxy; 
     wherein R 1  and R 2  form a benzene ring, a 5-7 membered aliphatic heterocycle containing 1-3 heteroatoms or a 5-7 membered aromatic heterocycle containing 1-3 heteroatoms together with the carbon atoms on the connected benzene ring; 
     R 2  and R 3  can form a benzene ring, a 5-7 membered aliphatic heterocycle containing 1-3 heteroatoms or a 5-7 membered aromatic heterocycle containing 1-3 heteroatoms together with the carbon atoms on the connected benzene ring; 
     the Q of the above formula I is selected from a stereoisomer of the compound shown by Q 1 . 
     A further preferred compound is: in the formula I: 
     X 1  is selected from hydrogen, cyano, nitro, halogen, C 1 -C 3  alkylsulfonyl, C 1 -C 3  alkylsulfinyl, C 1 -C 3  alkylthio, C 1 -C 3  haloalkylthio, C 1 -C 3  alkyl, C 1 -C 3  haloalkyl, C 1 -C 3  alkoxy, C 1 -C 3  alkoxy C 1 -C 3  alkyl, C 1 -C 3  alkoxy C 1 -C 3  alkoxy, C 1 -C 3  alkoxy C 1 -C 3  alkoxy C 1 -C 3  alkyl, C 3 -C 6  cycloalkyl or C 3 -C 6  cycloalkyloxy; 
     W is selected from N or CX 2 ; 
     X 2  is selected from hydrogen, cyano, nitro, halogen, C 1 -C 3  alkyl, C 1 -C 3  haloalkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl C 1 -C 3  alkyl, C 3 -C 6  halocycloalkyl C 1 -C 3  alkyl, Y 1  oxy, Y 1  thio, Y 1 Y 2  amino, Y 1  sulfinyl, Y 1  sulfonyl, Y 1  oxy C 1 -C 3  alkyl, Y 1  thio C 1 -C 3  alkyl, Y 1 Y 2  amino C 1 -C 3  alkyl, Y 1  sulfinyl C 1 -C 3  alkyl, Y 1  sulfonyl C 1 -C 3  alkyl, C(O)Y 1 , C(O)OY 1 , OC(O)OY 1 , N(Y 1 )C(O)OY 2 , C(O)N(Y 1 )Y 2 , N(Y 1 )C(O)N(Y 1 )Y 2 , OC(O)N(Y 1 )Y 2 , C(O)N(Y 1 )OY 2 , N(Y 1 )S(O) 2 Y 2 , N(Y 1 )C(O)Y 2 , OS(O) 2 Y 1 , CH═NOY 1 , C 1 -C 6  alkyl-CH═NOY 1 , C 1 -C 6  alkyl-O—N═C(Y 1 )Y 2 , phenyl, 5-7 membered alicyclic heterocycle containing 1-4 heteroatoms, 5-7 membered aromatic heterocycle containing 1-4 heteroatoms, 5-7 membered aliphatic heterocyclic C 1 -C 3  alkyl containing 1-4 heteroatoms or 5-7 membered aromatic heterocyclic C 1 -C 3  alkyl containing 1-4 heteroatoms; the hydrogen on the phenyl, the aliphatic heterocycle and the aromatic heterocycle mentioned above may be substituted by one or more of the following substituents which are selected from nitro, halogen, C 1 -C 3  alkyl, C 1 -C 3  haloalkyl, C 1 -C 3  alkoxy, C 3 -C 6  cycloalkyl or C 3 -C 6  cycloalkoxy; 
     Y 1  and Y 2  are independently selected from C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl C 1 -C 6  alkyl, C 1 -C 6  alkoxy C 1 -C 6  alkyl, phenyl, a 5-7 membered aliphatic heterocycle containing 1-4 heteroatoms, a 5-7 membered aromatic heterocycle containing 1-4 heteroatoms, a 5-7 membered aliphatic heterocyclic C 1 -C 6  alkyl containing 1-4 heteroatoms or a 5-7 membered aromatic heterocyclic C 1 -C 6  alkyl containing 1-4 heteroatoms; the hydrogen on the phenyl, the aliphatic heterocycle and the aromatic heterocycle mentioned above may be substituted by one or more of the following substituents which are selected from nitro, halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 3 -C 6  cycloalkyl or C 3 -C 6  cycloalkoxy; 
     X 3  is selected from hydrogen, cyano, halogen, C 1 -C 3  alkylsulfonyl, C 1 -C 3  alkylsulfinyl, C 1 -C 3  alkylthio, C 1 -C 3  haloalkylthio, C 1 -C 3  alkyl, C 1 -C 3  haloalkyl, C 1 -C 3  alkoxy, C 1 -C 3  alkoxy C 1 -C 3  alkyl, C 1 -C 3  alkoxy C 1 -C 3  alkoxy, C 1 -C 3  alkoxy C 1 -C 3  alkoxy C 1 -C 3  alkyl, C 3 -C 6  cycloalkyl or C 3 -C 6  cycloalkyloxy; 
     when X 1  is selected from chlorine and X 3  is selected from methylsulfonyl, X 2  is not 2-thiazolyl; 
     Z 1  is selected from C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  alkenyl, C 3 -C 6  alkynyl or phenyl; 
     Z 2  is selected from H, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl or phenyl; hydrogen on the phenyl mentioned above can be substituted by one or more of the following substituents; and the substituents are selected from halogen, cyano, nitro, C 1 -C 6  alkyl, C 3 -C 6  cycloalkyl or C 1 -C 6  haloalkyl; 
     Q is selected from Q 1  or Q 2  group; 
     
       
         
         
             
             
         
       
     
     Q 2  is selected from cycloalkenyl; the hydrogen on the ring may be substituted by the following substituents which are selected from C 1 -C 6  alkyl, C 1 -C 6  alkoxy or C 1 -C 6  alkenyl; 
     R 1  to R 5  are independently selected from hydrogen, hydroxyl, cyano, nitro, halogen, phenyl, C 1 -C 6  alkyl, C 2 -C 6  alkenyl, C 2 -C 6  alkynyl, C 1 -C 6  alkoxy or benzyloxy, wherein 
     R 1  and R 2  form a benzene ring or a 5-7 membered aliphatic heterocycle containing 1-3 heteroatoms together with the carbon atoms on the connected benzene ring; 
     R 2  and R 3  can form a benzene ring or a 5-7 membered aliphatic heterocycle containing 1-3 heteroatoms together with the carbon atoms on the connected benzene ring; 
     the Q of the above formula I is selected from a stereoisomer of the compound shown by Q 1 . 
     A further preferred compound is: in the formula I: 
     X 1  is selected from hydrogen, cyano, nitro, halogen, C 1 -C 3  alkylsulfonyl, C 1 -C 3  alkyl and C 1 -C 3  haloalkyl; 
     W is selected from N or CX 2 ; 
     X 2  is selected from hydrogen, halogen, C 1 -C 3  alkyl, C 1 -C 3  haloalkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl C 1 -C 3  alkyl, C 3 -C 6  halocycloalkyl C 1 -C 3  alkyl, Y 1  oxy, Y 1  thio, Y 1 Y 2  amino, Y 1  sulfonyl, Y 1  oxy C 1 -C 3  alkyl, Y 1  thio C 1 -C 3  alkyl, Y 1 Y 2  amino C 1 -C 3  alkyl, Y 1  sulfonyl C 1 -C 3  alkyl, C(O)Y 1 , C(O)OY 1 , OC(O)OY 1 , N(Y 1 )C(O)OY 2 , C(O)N(Y 1 )Y 2 , N(Y 1 )C(O)N(Y 1 )Y 2 , OC(O)N(Y 1 )Y 2 , C(O)N(Y 1 )OY 2 , N(Y 1 )S(O) 2 Y 2 , N(Y 1 )C(O)Y 2 , OS(O) 2 Y 1 , CH═NOY 1 , C 1 -C 6  alkyl-CH═NOY 1 , C 1 -C 6  alkyl-O—N═C(Y 1 )Y 2 , phenyl, 5-7 membered alicyclic heterocycle containing 1-4 heteroatoms, 5-7 membered aromatic heterocycle containing 1-4 heteroatoms, 5-7 membered aliphatic heterocyclic C 1 -C 3  alkyl containing 1-4 heteroatoms or 5-7 membered aromatic heterocyclic C 1 -C 3  alkyl containing 1-4 heteroatoms; the hydrogen on the phenyl, the aliphatic heterocycle and the aromatic heterocycle mentioned above may be substituted by one or more of the following substituents which are selected from nitro, halogen, C 1 -C 3  alkyl, C 1 -C 3  haloalkyl, C 1 -C 3  alkoxy, C 3 -C 6  cycloalkyl or C 3 -C 6  cycloalkoxy; 
     Y 1  and Y 2  are independently selected from C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 3 -C 6  cycloalkyl, C 3 -C 6  cycloalkyl C 1 -C 6  alkyl, C 1 -C 6  alkoxy C 1 -C 6  alkyl, phenyl, a 5-7 membered aliphatic heterocycle containing 1-4 heteroatoms, a 5-7 membered aromatic heterocycle containing 1-4 heteroatoms, a 5-7 membered aliphatic heterocyclic C 1 -C 6  alkyl containing 1-4 heteroatoms or a 5-7 membered aromatic heterocyclic C 1 -C 6  alkyl containing 1-4 heteroatoms; the hydrogen on the phenyl, the aliphatic heterocycle and the aromatic heterocycle mentioned above may be substituted by one or more of the following substituents which are selected from nitro, halogen, C 1 -C 6  alkyl, C 1 -C 6  haloalkyl, C 1 -C 6  alkoxy, C 1 -C 6  haloalkoxy, C 3 -C 6  cycloalkyl or C 3 -C 6  cycloalkoxy; 
     X 3  is selected from hydrogen, cyano, halogen, C 1 -C 3  alkylsulfonyl, C 1 -C 3  alkyl and C 1 -C 3  haloalkyl; 
     when X 1  is selected from chlorine and X 3  is selected from methylsulfonyl, X 2  is not 2-thiazolyl; 
     Z 1  is selected from C 1 -C 3  alkyl or phenyl; 
     Z 2  is selected from H, C 1 -C 3  alkyl and C 1 -C 3  haloalkyl; 
     Q is selected from Q 1  or Q 2  group; 
     
       
         
         
             
             
         
       
     
     Q 2  is selected from G1, G2, G3, G4, G5 or G6 group; 
     
       
         
         
             
             
         
       
     
     R 1  to R 5  are independently selected from hydrogen, hydroxyl, cyano, nitro, halogen, phenyl, methyl, ethyl, propyl, vinyl, propenyl, ethynyl, propynyl, methoxy, ethoxyl, benzyloxy, trifluoromethyl or trifluoromethoxy; 
     R 1  and R 2  are selected from a benzene ring formed together with the carbon atoms on the connected benzene ring; 
     R 2  and R 3  are selected from a benzene ring, 1,3-dioxane ring or 1,4-dioxane ring formed together with the carbon atoms on the connected benzene ring; 
     the Q of the above formula I is selected from a trans-stereoisomer of the compound shown by Q 1 . 
     In the definitions of the compounds of the formula I provided above, the terms used in the collection are defined as follows: 
     Alkyl refers to linear or branched groups such as methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl and n-hexyl and so on. Cycloalkyl refers to groups in the form of cyclic chain, such as cyclopropyl, methylcyclopropyl, cyclopropylcyclopropyl, cyclobutyl, cyclopentyl and cyclohexyl and so on. Alkenyl refers to linear or branched alkenyl, such as vinyl, 1-propenyl, 2-propenyl, butenyl, pentenyl and hexenyl and so on. Alkynyl refers to linear or branched chain alkynyl, such as 1-propynyl, 2-propynyl, butynyl, pentynyl and hexynyl and so on. Alkoxy refers to a group having an oxygen atom at the end of the alkyl, such as methoxy, ethoxy, n-propoxy, isopropoxy and tert-butoxy and so on. The 5-7-membered heterocycle containing 1-4 heteroatoms refers to a 5-7-membered heterocyclic compound containing 1-4 heteroatoms without aromatic characteristics, such as ethylene oxide, tetrahydrofuran, imidazolinone, caprolactam, 1,3-dioxane ring and 1,4-dioxane ring and so on. The 5-7-membered aromatic heterocycle containing 1-4 heteroatoms refers to a 5-7-membered heterocyclic compound containing 1-4 heteroatoms having aromatic characteristics, such as furan, thiophene, pyrazole and pyridine and so on. Stereoisomers mean that hydrogen atoms on the carbon-carbon double bond B in the formula I are on the same side (cis) or on both sides (trans) of the bond B. 
     The compound of the formula I in the present invention can be prepared by the following method: 
     
       
         
         
             
             
         
       
     
     The compound of the formula II and the compound of the formula III react in a suitable solvent at temperature of −10° C. to a boiling point of the suitable solvent for 0.5-48 hours to obtain a target compound I. The suitable solvent is selected from dichloromethane, 1,2-dichloroethane, chloroform, carbon tetrachloride, hexane, benzene, toluene, ethyl acetate, acetonitrile, acetic acid, tetrahydrofuran, dioxane, N,N-dimethylformamide or dimethylsulfoxide and so on. 
     Addition of a suitable alkali substance can be beneficial to the reaction. The suitable alkali is selected from organic alkali such as triethylamine, N, N-dimethylaniline or pyridine and so on, or inorganic alkali such as sodium hydroxide, potassium hydroxide, sodium carbonate, sodium bicarbonate, potassium carbonate, sodium methoxide, sodium tert-butoxide or potassium tert-butoxide and so on. 
     The compound of the formula III can be prepared from the corresponding acid (commercially available) by reference to Modern Agrochemicals 10(5), 16-20, 23; 2011. 
     The preparation method of the compound of the formula II is as follows: 
     
       
         
         
             
             
         
       
     
     The compound of the formula IV reacts under the action of alkali and catalyst in a suitable solvent at temperature of −10° C. to a boiling point of the suitable solvent for 0.5-48 hours to obtain a compound of formula II. The suitable solvent is selected from dichloromethane, 1,2-dichloroethane, chloroform, carbon tetrachloride, hexane, benzene, toluene, ethyl acetate, acetonitrile, acetic acid, tetrahydrofuran, dioxane, N,N-dimethylformamide or dimethylsulfoxide and so on. Proper alkali is selected from sodium carbonate, potassium carbonate or triethylamine and so on. A proper catalyst is selected from sodium carbonate, potassium carbonate, acetone cyanohydrin, azide, azide quaternary ammonium salt, metal cyanide or DMAP and so on. 
     The preparation method of the compound of the formula IV is as follows: 
     
       
         
         
             
             
         
       
     
     The compound of the formula V and the compound of the formula VI (commercially available or prepared by the method described in reference EP0240001) react in a suitable solvent at temperature of −10° C. to a boiling point of the suitable solvent for 0.5-24 hours to obtain the compound of the formula IV. The suitable solvent is selected from dichloromethane, 1,2-dichloroethane, chloroform, carbon tetrachloride, hexane, benzene, toluene, ethyl acetate, acetonitrile, acetic acid, tetrahydrofuran, dioxane, N,N-dimethylformamide or dimethylsulfoxide and so on. 
     Addition of a suitable alkali substance can be beneficial to the reaction. The suitable alkali is selected from organic alkali such as triethylamine, N, N-dimethylaniline or pyridine and so on, or inorganic alkali such as sodium hydroxide, potassium hydroxide, sodium carbonate, sodium bicarbonate, potassium carbonate, sodium methoxide, sodium tert-butoxide or potassium tert-butoxide and so on. 
     The corresponding raw material carboxylic acid (commercially available) of the compound of the formula V and an acyl halide reagent react in a suitable solvent at temperature of −10° C. to a boiling point of the suitable solvent for 0.5-48 hours to obtain the compound of the formula V. The acyl halide reagent is selected from oxalyl chloride, thionyl chloride, phosphorous oxychloride, phosphorus trichloride or phosphorus pentachloride and so on. The suitable solvent is selected from dichloromethane, 1,2-dichloroethane, hexane, benzene, toluene, acetonitrile, acetic acid, dioxane or liquid acyl halide reagent and so on. 
     The compound of the formula I of the present invention and the stereoisomer thereof or the compound of the formula I and the agriculturally acceptable salt of the isomer have herbicidal activity and can be used for agriculturally controlling various weeds. 
     The present invention also comprises a herbicidal composition using the compound of the formula I and the stereoisomer thereof or the compound of the formula I and the agriculturally acceptable salt of the isomer as active ingredients. The weight percentage of the active ingredient in the herbicidal composition is 1-99%. The herbicidal composition also comprises an agriculturally acceptable carrier. 
     The herbicidal composition of the present invention can be applied in the forms of various formulations. The compound of the present invention is generally dissolved or dispersed in the carrier and prepared into the formulation for easier dispersion when used as a herbicide. For example, the chemical formulations can be prepared into wettable powder or missible oil. Therefore, in the compositions, at least one liquid or solid carrier is added, and generally a suitable surfactant needs to be added. 
     The present invention also provides an implementing method for controlling weeds. The method comprises applying an effective dose of the herbicidal composition of the present invention to the weed or a weed growing place or a surface of a growth medium thereof. A suitable effective dose is 1 to 1000 grams per hectare, and a preferred effective dose is 10 to 500 grams per hectare. For some applications, one or more other herbicides can be added to the herbicidal composition of the present invention, thereby generating additional advantages and effects. 
     The compound of the present invention can be used alone or in combination with other known pesticides, bactericides, plant growth regulators or fertilizers. 
     Compared with the prior art, the alkene-containing carboxylate compound of the present invention not only has excellent herbicidal activity, but also is safe for crops. 
     It should be clear that various changes and modifications can be made within the scope defined by the claims of the present invention. 
    
    
     DETAILED DESCRIPTION 
     The following examples and biometric test results can be used to further illustrate the present invention, but are not intended to limit the present invention. 
     Synthesis Example 
     Embodiment 1 Synthesis of Compound 1-1 
     (1) Synthesis of 2-methanesulfonyl-4-trifluoromethyl benzoyl chloride 
     
       
         
         
             
             
         
       
     
     2-methanesulfonyl-4-trifluoromethylbenzoic acid (30 g, 112 mmol) and toluene (200 ml) were added to a reaction flask; thionyl chloride (53 g, 447 mmol) was slowly added; the mixture was heated and refluxed for 4 hours; and the solvent was evaporated under reduced pressure to obtain 32 g of yellow solid, which is directly used in the next step. 
     (2) Synthesis of 2-methanesulfonyl-4-trifluoromethyl benzoic acid (1,3-dimethylpyrazole-5-yl) ester 
     
       
         
         
             
             
         
       
     
     1,3-dimethyl-5-hydroxypyrazole (13 g, 112 mmol), 1,2-dichloroethane (200 ml) and triethylamine (34 g, 336 mmol) were added to the reaction flask, and the 1,2-dichloroethane solution (100 ml) of 2-methanesulfonyl-4-trifluoromethyl benzoyl chloride in the above step was added dropwise. The mixture was stirred at room temperature for 1 hour; the solvent was evaporated under reduced pressure; ethyl acetate (1000 ml) was added to the residue; water (500 ml) was used for separation and extraction; the organic phase was sequentially washed with saturated salt water (500 ml) and dried with anhydrous magnesium sulfate; the solvent was evaporated under reduced pressure; and the residue was separated by column chromatography to obtain 28 g of yellow solid, with a yield of 68%. 
     (3) Synthesis of 1,3-dimethyl-4-(2-methanesulfonyl-4-trifluoromethylbenzoyl)-5-hydroxypyrazole 
     
       
         
         
             
             
         
       
     
     2-methanesulfonyl-4-trifluoromethyl benzoic acid (1,3-dimethylpyrazole-5-yl) ester (6 g, 16.6 mmol), 1,2-dichloroethane (50 ml), triethylamine (15 g, 148 mmol) and acetone cyanohydrin (1 ml) were added to the reaction flask; the mixture was kept at 60° C. to react for 6 hours and cooled to room temperature; water (100 ml) was added to the reaction solution, and shaken thoroughly and layered; the pH of the aqueous phase was adjusted to be 2-3 with 20% hydrochloric acid, and the aqueous phase was extracted twice with ethyl acetate (100 ml). The organic phase was washed with saturated salt water (50 ml) and dried with anhydrous magnesium sulfate; and the solvent was evaporated under reduced pressure to obtain 5.4 g of red oil with a yield of 90%. 
     (4) Synthesis of Cinnamyl Chloride 
     
       
         
         
             
             
         
       
     
     Cinnamic acid (0.17 g, 1.1 mmol), dichloromethane (30 ml) and DMF (1 drop) were added into the reaction flask; oxalyl chloride (0.7 g, 5.5 mmol) was slowly added; the mixture was stirred at room temperature for 1 hour; the solvent was evaporated under reduced pressure; toluene (15 ml) was added to the residue and stirred for 3 minutes; and then the solvent was evaporated under reduced pressure to obtain 0.18 g of pale yellow solid which was used directly in the next step. 
     (5) Synthesis of Compound 1-1 
     
       
         
         
             
             
         
       
     
     1,3-dimethyl-4-(2-methanesulfonyl-4-trifluoromethylbenzoyl)-5-hydroxypyrazole (0.4 g, 1.1 mmol), dichloromethane (20 ml) and triethylamine (0.22 g, 2.2 mmol) were added to the reaction flask, and the dichloromethane solution (15 ml) of cinnamyl chloride in the above step was added dropwise. The mixture was stirred at room temperature for 1 hour; the solvent was evaporated under reduced pressure; ethyl acetate (100 ml) was added to the residue; water (50 ml) was used for separation and extraction; the organic phase was sequentially washed with saturated salt water (50 ml) and dried with anhydrous magnesium sulfate; the solvent was evaporated under reduced pressure; and the residue was separated by column chromatography to obtain 0.35 g of white solid compound 1, with a purity of 99.3% and a yield of 64%. 
     Embodiment 2 Synthesis of Compound 1-7 
     (1) Synthesis of 3,4-(methylenedioxy) cinnamyl Chloride 
     
       
         
         
             
             
         
       
     
     3,4-(methylenedioxy) cinnamic acid (0.21 g, 1.1 mmol), dichloromethane (30 ml) and DMF (1 drop) were added into the reaction flask; oxalyl chloride (0.7 g, 5.5 mmol) was slowly added; the mixture was stirred at room temperature for 1 hour; the solvent was evaporated under reduced pressure; toluene (15 ml) was added to the residue and stirred for 3 minutes; and then the solvent was evaporated under reduced pressure to obtain 0.23 g of pale yellow solid which was used directly in the next step. 
     (2) Synthesis of Compound 1-7 
     
       
         
         
             
             
         
       
     
     1,3-dimethyl-4-(2-methanesulfonyl-4-trifluoromethylbenzoyl)-5-hydroxypyrazole (0.4 g, 1.1 mmol, see step 3 of embodiment 1 for preparation), dichloromethane (20 ml) and triethylamine (0.22 g, 2.2 mmol) were added to the reaction flask, and the dichloromethane solution (15 ml) of 3,4-(methylenedioxy) cinnamyl chloride in the above step was added dropwise. The mixture was stirred at room temperature for 1 hour; the solvent was evaporated under reduced pressure; ethyl acetate (100 ml) was added to the residue; water (50 ml) was used for separation and extraction; the organic phase was sequentially washed with saturated salt water (50 ml) and dried with anhydrous magnesium sulfate; the solvent was evaporated under reduced pressure; and the residue was separated by column chromatography to obtain 0.38 g of pale yellow solid compound 7, with a purity of 94.6% and a yield of 60.7%. 
     Embodiment 3 Synthesis of Compound 2-379 
     (1) Synthesis of 1-cyclohexenoyl Chloride 
     
       
         
         
             
             
         
       
     
     1-cyclohexenoic acid (0.14 g, 1.1 mmol), dichloromethane (30 ml) and DMF (1 drop) were added into the reaction flask; oxalyl chloride (0.7 g, 5.5 mmol) was slowly added; the mixture was stirred at room temperature for 1 hour; the solvent was evaporated under reduced pressure; toluene (15 ml) was added to the residue and stirred for 3 minutes; and then the solvent was evaporated under reduced pressure to obtain 0.16 g of pale yellow solid which was used directly in the next step. 
     (2) Synthesis of Compound 2-379 
     
       
         
         
             
             
         
       
     
     1,3-dimethyl-4-(2-methanesulfonyl-4-trifluoromethylbenzoyl)-5-hydroxypyrazole (0.4 g, 1.1 mmol, see step 3 of embodiment 1 for preparation), dichloromethane (20 ml) and triethylamine (0.22 g, 2.2 mmol) were added to the reaction flask, and the dichloromethane solution (15 ml) of 1-cyclohexenoyl chloride in the above step was added dropwise. The mixture was stirred at room temperature for 1 hour; the solvent is evaporated under reduced pressure; ethyl acetate (100 ml) was added to the residue; water (50 ml) was used for separation and extraction; the organic phase was sequentially washed with saturated salt water (50 ml) and dried with anhydrous magnesium sulfate; the solvent was evaporated under reduced pressure; and the residue was separated by column chromatography to obtain 0.4 g of off-white solid compound 2-379, with a purity of 99.4% and a yield of 77.1%. 
     Embodiment 4 Synthesis of Compound 1-16 
     (1) Synthesis of 2-chloro-3-methoxymethyl-4-methylsulfonyl benzoyl chloride 
     
       
         
         
             
             
         
       
     
     2-methanesulfonyl-4-trifluoromethylbenzoic acid (4 g, 14.35 mmol), dichloromethane (30 ml) and DMF (1 drop) were added into the reaction flask; oxalyl chloride (9.11 g, 71.8 mmol) was slowly added; the mixture was stirred at room temperature for 40 minutes; the solvent was evaporated under reduced pressure; toluene (15 ml) was added to the residue and stirred for 3 minutes; and then the solvent was evaporated under reduced pressure to obtain 4.26 g of yellow solid which was used directly in the next step. 
     (2) Synthesis of 2-chloro-3-methoxymethyl-4-methylsulfonyl benzoic acid (1,3-dimethylpyrazole-5-yl) ester 
     
       
         
         
             
             
         
       
     
     1,3-dimethyl-5-hydroxypyrazole (1.77 g, 15.79 mmol), dichloroethane (100 ml) and triethylamine (2.9 g, 28.7 mmol) were added to the reaction flask, and the dichloroethane solution (30 ml) of 2-chloro-3-methoxymethyl-4-methylsulfonyl benzoyl chloride in the above step was added dropwise. The mixture was stirred at room temperature for 1 hour; the solvent was evaporated under reduced pressure; ethyl acetate (100 ml) was added to the residue; water (1000 ml) was used for separation and extraction; the organic phase was sequentially washed with saturated salt water (100 ml) and dried with anhydrous magnesium sulfate; the solvent was evaporated under reduced pressure; and the residue was separated by column chromatography to obtain 3.4 g of off-white solid, with a yield of 63.5%. 
     (3) Synthesis of 1,3-dimethyl-4-(2-chloro-3-methoxymethyl-4-methylsulfonyl benzoyl)-5-hydroxypyrazole 
     
       
         
         
             
             
         
       
     
     2-chloro-3-methoxymethyl-4-methylsulfonyl benzoic acid (1,3-dimethylpyrazole-5-yl) ester (3.4 g, 9.12 mmol), dichloromethane (100 ml), triethylamine (1.38 g, 13.68 mmol) and acetone cyanohydrin (1 ml) were added to the reaction flask to react at room temperature for 12 hours; and water extraction (50 ml (3)) was added to the reaction solution. After the aqueous phase was collected, the pH was adjusted to be 2-3 with 20% hydrochloric acid, and the aqueous phase was extracted twice with ethyl acetate (100 ml). The organic phase was washed with saturated salt water (50 ml) and dried with anhydrous magnesium sulfate; and the solvent was evaporated under reduced pressure to obtain 3.26 g of yellow solid with a yield of 96%. 
     (4) Synthesis of Compound 1-16 
     
       
         
         
             
             
         
       
     
     1,3-dimethyl-4-(2-chloro-3-methoxymethyl-4-methylsulfonyl benzoyl)-5-hydroxypyrazole (0.4 g, 1.07 mmol), dichloromethane (20 ml) and triethylamine (0.22 g, 2.15 mmol) were added to the reaction flask, and the dichloromethane solution (15 ml, see step 4 of embodiment 1 for preparation) of cinnamyl chloride in the above step was added dropwise. The mixture was stirred at room temperature for 1 hour; the solvent was evaporated under reduced pressure; ethyl acetate (100 ml) was added to the residue; water (50 ml) was used for separation and extraction; the organic phase was sequentially washed with saturated salt water (50 ml) and dried with anhydrous magnesium sulfate; the solvent was evaporated under reduced pressure; and the residue was separated by column chromatography to obtain 0.31 g of white solid compound 16, with a purity of 93.2% and a yield of 53.5%. 
     Embodiment 5 Synthesis of Compound 2-307 
     
       
         
         
             
             
         
       
     
     1,3-dimethyl-4-(2-chloro-3-methoxymethyl-4-methylsulfonyl benzoyl)-5-hydroxypyrazole (0.4 g, 1.1 mmol, see step 3 of embodiment 4 for preparation), dichloromethane (20 ml) and triethylamine (0.22 g, 2.2 mmol) were added to the reaction flask, and the dichloromethane solution of 1-cyclohexene-1-acyl chloride (0.2 g of 1.1 mmol 1-cyclohexene-1-acyl chloride was dissolved in 15 ml of dichloromethane, see step 1 of embodiment 3 for preparation) was added dropwise. The mixture was stirred at room temperature for 1 hour; the solvent was evaporated under reduced pressure; ethyl acetate (100 ml) was added to the residue; water (50 ml) was used for separation and extraction; the organic phase was sequentially washed with saturated salt water (50 ml) and dried with anhydrous magnesium sulfate; the solvent was evaporated under reduced pressure; and the residue was separated by column chromatography to obtain 0.45 g of white solid, with a purity of 99.6% and a yield of 87%. 
     The initial substances are replaced according to the above recorded method to obtain other compounds shown by the formula I. Part of the compounds of the formula I can be found in Table 1, Table 2, Table 3 and Table 4, wherein in Table 1 and Table 2, W is selected from CX 2  and the stereo configuration in Table 1 is trans; in Table 3 and Table 4, W is selected from N and the stereo configuration in Table 3 is trans. 
     In the compound of the formula I, W is CX 2  and the stereo configuration is trans. 
     
       
         
         
             
             
         
       
     
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Structures and Physical Properties of Part of Compounds of Formula 1 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 Appearance 
               
               
                 Com- 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (Melting 
               
               
                 pound 
                 X 1   
                 X 2   
                 X 3   
                 Z 1   
                 Z 2   
                 R 1   
                 R 2   
                 R 3   
                 R 4   
                 R 5   
                 Point° C.) 
               
               
                   
               
               
                 1-1 
                 SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 white solid 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (144-146) 
               
               
                 1-2 
                 SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
                 CH 3   
                 Cl 
                 H 
                 Cl 
                 H 
                 H 
                   
               
               
                 1-3 
                 SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 OCH 3   
                 H 
                 H 
                   
               
               
                 1-4 
                 SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 NO 2   
                 H 
                 H 
                   
               
               
                 1-5 
                 SO 2 CH 3   
                 H 
                 CF 5   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 CH 3   
                 H 
                 H 
                   
               
               
                   
               
               
                 1-6 
                 SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-7 
                 SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 pale  yellow  solid (99-101) 
               
               
                   
               
               
                 1-8 
                 SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-9 
                 SO 2 CH 3   
                 H 
                 CF 5   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-10 
                 SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-11 
                 SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                 1-12 
                 SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                 1-13 
                 SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
                 CH 2 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-14 
                 SO 2 CH 3   
                 H 
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-15 
                 SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-16 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 white  solid (139-141) 
               
               
                   
               
               
                 1-17 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 Cl 
                 H 
                 Cl 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-18 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 OCH 3   
                 H 
                 H 
                 white solid (151-153) 
               
               
                   
               
               
                 1-19 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 NO 2   
                 H 
                 H 
                   
               
               
                   
               
               
                 1-20 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 CF 3   
                 H 
                 H 
                 white  solid (139-141) 
               
               
                   
               
               
                 1-21 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 pale pink  solid (195-197) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-22 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 pale  yellow  solid (160-162) 
               
               
                   
               
               
                 1-23 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-24 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-25 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-26 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO2CH 3   
                 CH 3   
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-27 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-28 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 2 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-29 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                   
                   
                   
                   
                 U 
                   
                   
                   
                   
                   
                   
                   
               
               
                   
               
               
                 1-30 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-31 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 pale  
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 yellow  
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (199-201) 
               
               
                 1-32 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 Cl 
                 H 
                 Cl 
                 H 
                 H 
                   
               
               
                 1-33 
                 Cl 
                 CH 3   
                 CO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 OCH 3   
                 H 
                 H 
                   
               
               
                 1-34 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 NO 3   
                 H 
                 H 
                   
               
               
                 1-35 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 CF 3   
                 H 
                 H 
                   
               
               
                   
               
               
                 1-36 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-37 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 white  solid (227-229) 
               
               
                   
               
               
                 1-38 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-39 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-40 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-41 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-42 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 H 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 yellow solid (151-152) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-43 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 2 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-44 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-45 
                 Cl 
                 CH 3   
                 SO.CH, 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-46 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-47 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 Cl 
                 H 
                 Cl 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-48 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 OCH 3   
                 H 
                 H 
                   
               
               
                   
               
               
                 1-49 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 NO 2   
                 H 
                 H 
                   
               
               
                   
               
               
                 1-50 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 CF 3   
                 H 
                 H 
                   
               
               
                   
               
               
                 1-51 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-52 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-53 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-54 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-55 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-56 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-57 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-58 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 2 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-59 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-60 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-61 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-62 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 Cl 
                 H 
                 Cl 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-63 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 OCH 3   
                 H 
                 H 
                   
               
               
                   
               
               
                 1-64 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 NO 2   
                 H 
                 H 
                   
               
               
                   
               
               
                 1-65 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 CF 3   
                 H 
                 H 
                   
               
               
                   
               
               
                 1-66 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-67 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-68 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-69 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-70 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-71 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-72 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-73 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 2 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-74 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-75 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-76 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 white  solid (123-125) 
               
               
                   
               
               
                 1-77 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 Cl 
                 H 
                 Cl 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-78 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 OCH 3   
                 H 
                 H 
                   
               
               
                   
               
               
                 1-79 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 NO 2   
                 H 
                 H 
                   
               
               
                   
               
               
                 1-80 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 CF 3   
                 H 
                 H 
                   
               
               
                   
               
               
                 1-81 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 yellow  solid (135-136) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-82 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 yellow  solid (87-88) 
               
               
                   
               
               
                 1-83 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-84 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-85 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-86 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CF 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-87 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-88 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 2 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-89 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-90 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-91 
                 Cl 
                 CH 2 Br 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-92 
                 Cl 
                 CH 2 Br 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-93 
                 Cl 
                 CH 2 Br 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-94 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-95 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-96 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-97 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-98 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-99 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-100 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-101 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-102 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-103 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-104 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-105 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-106 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-107 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-108 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-109 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-110 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-111 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-112 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-113 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-114 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-115 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 pale  yellow  oil 
               
               
                   
               
               
                 1-116 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-117 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-118 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-119 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-120 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-121 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-122 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-123 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-124 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-125 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-126 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-127 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-128 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-129 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-130 
                 Cl 
                 SO 2 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-131 
                 Cl 
                 SO 2 CH 3   
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-132 
                 Cl 
                 SO 2 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-133 
                 Cl 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-134 
                 Cl 
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-135 
                 Cl 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-136 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-137 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-138 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-139 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-140 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-141 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-142 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-143 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-144 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-145 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-146 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-147 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-148 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-149 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-150 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-151 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-152 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-153 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-154 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-155 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-156 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-157 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-158 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-159 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-160 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-161 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-162 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-163 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-164 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-165 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-166 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-167 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-168 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-169 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-170 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-171 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-172 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-173 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-174 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-175 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-176 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-177 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-178 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-179 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-180 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-181 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-182 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-183 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-184 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-185 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-186 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-187 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-188 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-189 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-190 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-191 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-192 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-193 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-194 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-195 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-196 
                 Cl 
                 CN 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-197 
                 Cl 
                 CN 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-198 
                 Cl 
                 CN 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-199 
                 Cl 
                 NO 2   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-200 
                 Cl 
                 NO 2   
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-201 
                 Cl 
                 NO 2   
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-202 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-203 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-204 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-205 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-206 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-207 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-208 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-209 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-210 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-211 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-212 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-213 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-214 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-215 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-216 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-217 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-218 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-219 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-220 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-221 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-222 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-223 
                 Cl 
                 H 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 white  
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (150-152) 
               
               
                   
               
               
                 1-224 
                 Cl 
                 H 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-225 
                 Cl 
                 H 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-226 
                 Cl 
                 H 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 pale  yellow  solid (185-187) 
               
               
                   
               
               
                 1-227 
                 Cl 
                 H 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-228 
                 Cl 
                 H 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-229 
                 Cl 
                 H 
                 Cl 
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 pale  
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 yellow 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (95-97) 
               
               
                   
               
               
                 1-230 
                 Cl 
                 H 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-231 
                 Cl 
                 H 
                 Cl 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-232 
                 Cl 
                 H 
                 Cl 
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 pale  yellow  solid (114-116) 
               
               
                   
               
               
                 1-233 
                 Cl 
                 H 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-234 
                 Cl 
                 H 
                 Cl 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-235 
                 NO 2   
                 H 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 orange  
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (196-198) 
               
               
                   
               
               
                 1-236 
                 NO 2   
                 H 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-237 
                 NO 2   
                 H 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-238 
                 NO 2   
                 H 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 yellow  solid (173-175) 
               
               
                   
               
               
                 1-239 
                 NO 2   
                 H 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-240 
                 NO 2   
                 H 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-241 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-242 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-243 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-244 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-245 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-246 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-247 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-248 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-249 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-250 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-251 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-252 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-253 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-254 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-255 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-256 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-257 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-258 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-259 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 pale  yellow  solid (70-72) 
               
               
                   
               
               
                 1-260 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-261 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-262 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 pale  yellow  solid (134-136) 
               
               
                   
               
               
                 1-263 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-264 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 1-265 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 white  solid (187-188) 
               
               
                   
               
               
                 1-266 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-267 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-268 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 white  
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (191-193) 
               
               
                   
               
               
                 1-269 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-270 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-271 
                 CH 3   
                 CH 2 Br 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-272 
                 CH 3   
                 CH 2 Br 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-273 
                 CH 3   
                 CH 2 Br 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-274 
                 CH 3   
                 F 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-275 
                 CH 3   
                 F 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-276 
                 CH 3   
                 F 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-277 
                 CH 3   
                 Br 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-278 
                 CH 3   
                 Br 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-279 
                 CH 3   
                 Br 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-280 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 pale  yellow  solid (152-154) 
               
               
                   
               
               
                 1-281 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-282 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-283 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-284 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-285 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-286 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-287 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                   
                   
                   
                   
                 I 
                   
                   
                   
                   
                   
                   
                   
               
               
                   
               
               
                 1-288 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-289 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-290 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-291 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-292 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 H 
                 off- white  solid (118-120) 
               
               
                   
               
               
                 1-293 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH, 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-294 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-295 
                 CN 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-296 
                 CN 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-297 
                 CN 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-298 
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-299 
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-300 
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-301 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-302 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-303 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-304 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-305 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-306 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-307 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-308 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-309 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-310 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-311 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-312 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-313 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-314 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-315 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-316 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-317 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-318 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-319 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-320 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-321 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-322 
                 SO 2 CH═CH, 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-323 
                 SO 2 CH═CH, 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-324 
                 SO 2 CH═CH 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-325 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-326 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-327 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-328 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-329 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-330 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-331 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-332 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-333 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-334 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-335 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-336 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-337 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-338 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-339 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-340 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-341 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-342 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-343 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-344 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-345 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-346 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 white  solid (135-137) 
               
               
                   
               
               
                 1-347 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-348 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-349 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 yellow  oil 
               
               
                   
               
               
                 1-350 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-351 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-352 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-353 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-354 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-355 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-356 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-357 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-358 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-359 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-360 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-361 
                 CH 3   
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-362 
                 CH 3   
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-363 
                 CH 3   
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-364 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-365 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-366 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-367 
                 NO 2   
                 H 
                 Cl 
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 orange  
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (107-109) 
               
               
                   
               
               
                 1-368 
                 NO 2   
                 H 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-369 
                 NO 2   
                 H 
                 Cl 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 1-370 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 OCH 3   
                 H 
                 H 
                 yellow  oil 
               
               
                   
               
               
                 1-371 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 white  
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (153-154) 
               
               
                   
               
               
                 1-372 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 H 
                 H 
                 H 
                 H 
                 H 
                 yellow  oil 
               
               
                   
               
               
                 1-373 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 yellow  oil 
               
               
                   
               
               
                 1-374 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 yellow  oil 
               
               
                   
               
               
                 1-375 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 yellow  oil 
               
               
                   
               
               
                 1-376 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 pale  yellow  oil 
               
               
                   
               
               
                 1-377 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 pale  yellow  oil 
               
               
                   
               
            
           
         
       
     
     In the compound of the formula I, W is CX 2 . 
     
       
         
         
             
             
         
       
     
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 Structures and Physical Properties of Part of Compounds of Formula I 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                   
                   
                 Appearance 
               
               
                 Com- 
                   
                   
                   
                   
                   
                   
                 (Melting  
               
               
                 pound 
                 X 1   
                 X 2   
                 X 3   
                 Z 1   
                 Z 2   
                 Q 
                 Point ° C.) 
               
               
                   
               
               
                 2-1 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 white solid (170-171) 
               
               
                   
               
               
                 2-2 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-3 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-4 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-5 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-6 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-7 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-8 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-9 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-10 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-11 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-12 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-13 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-14 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-15 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-16 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-17 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-18 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-19 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 white solid (164-165) 
               
               
                   
               
               
                 2-20 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-21 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-22 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-23 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-24 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-25 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-26 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-27 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-28 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-29 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-30 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-31 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-32 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-33 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-34 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-35 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-36 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-37 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 white solid (157-158) 
               
               
                   
               
               
                 2-38 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-39 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-40 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-41 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-42 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-43 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-44 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-45 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-46 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-47 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-48 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-49 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-50 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-51 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-52 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-53 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-54 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-55 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow oil 
               
               
                   
               
               
                 2-56 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-57 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 pale yellow  solid (134-136) 
               
               
                   
               
               
                 2-58 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-59 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-60 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-61 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow oil 
               
               
                   
               
               
                 2-62 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-63 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow oil 
               
               
                   
               
               
                 2-64 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-65 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-66 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-67 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow oil 
               
               
                   
               
               
                 2-68 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-69 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-70 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-71 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-72 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-73 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 brown oil 
               
               
                   
               
               
                 2-74 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-75 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-76 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-77 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-78 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-79 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-80 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-81 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-82 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-83 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-84 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-85 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-86 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-87 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-88 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-89 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-90 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-91 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-92 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-93 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-94 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-95 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-96 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-97 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-98 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-99 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-100 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-101 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-102 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-103 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-104 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-105 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-106 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-107 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-108 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-109 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-110 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-111 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-112 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-113 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-114 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-115 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-116 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-117 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-118 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-119 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-120 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-121 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 white solid (209-210) 
               
               
                   
               
               
                 2-122 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-123 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 white solid (199-200) 
               
               
                   
               
               
                 2-124 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-125 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-126 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-127 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 white solid (186-188) 
               
               
                   
               
               
                 2-128 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-129 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-130 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-131 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-132 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-133 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-134 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-135 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-136 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-137 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-138 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3 CH 2   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-139 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-140 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-141 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-142 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-143 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-144 
                 CH 3   
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-145 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 white solid (116-118) 
               
               
                   
               
               
                 2-146 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-147 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-148 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-149 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-150 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-151 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-152 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-153 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-154 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-155 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-156 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-157 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-158 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-159 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-160 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-161 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-162 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-163 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-164 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-165 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-166 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-167 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-168 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-169 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-170 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-171 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-172 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-173 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-174 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-175 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-176 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-177 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-178 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-179 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-180 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-181 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-182 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-183 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-184 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-185 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-186 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-187 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-188 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-189 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-190 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-191 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-192 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-193 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-194 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-195 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-196 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-197 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-198 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-199 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-200 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-201 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-202 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-203 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-204 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-205 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-206 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-207 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-208 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-209 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-210 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-211 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-212 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-213 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-214 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-215 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-216 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-217 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-218 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-219 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-220 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-221 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-222 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-223 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-224 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-225 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-226 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-227 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-228 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-229 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-230 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-231 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-232 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-233 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-234 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-235 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-236 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-237 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-238 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-239 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-240 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-241 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-242 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-243 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-244 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-245 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-246 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-247 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-248 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-249 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-250 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-251 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-252 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-253 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-254 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-255 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-256 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-257 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-258 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-259 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-260 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-261 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-262 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-263 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-264 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-265 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-266 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-267 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-268 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-269 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-270 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-271 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-272 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-273 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-274 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-275 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-276 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-277 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-278 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-279 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-280 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-281 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-282 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-283 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-284 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-285 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-286 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-287 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-288 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-289 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 white solid (172-174) 
               
               
                   
               
               
                 2-290 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-291 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 white solid (137-139) 
               
               
                   
               
               
                 2-292 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-293 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-294 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-295 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-296 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-297 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-298 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-299 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-300 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-301 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-302 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-303 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-304 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-305 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-306 
                 Cl 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-307 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 white solid  (181-183) 
               
               
                   
               
               
                 2-308 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-309 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow solid (128-130) 
               
               
                   
               
               
                 2-310 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-311 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-312 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-313 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-314 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-315 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-316 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-317 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-318 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-319 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-320 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-321 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-322 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-323 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-324 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-325 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-326 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-327 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-328 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-329 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-330 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-331 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-332 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-333 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-334 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-335 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-336 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-337 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-338 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-339 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-340 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-341 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-342 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-343 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 white solid (170-171) 
               
               
                   
               
               
                 2-344 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-345 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-346 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-347 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-348 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-349 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-350 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-351 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-352 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-353 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-354 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-355 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-356 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-357 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-358 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-359 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-360 
                 SO 2 CH 3   
                 H 
                 Cl 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-361 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-362 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-363 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-364 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-365 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-366 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-367 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-368 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-369 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-370 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-371 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-372 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-373 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-374 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-375 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-376 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-377 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-378 
                 Cl 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-379 
                 SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 while solid (129-131) 
               
               
                   
               
               
                 2-380 
                 SO 2 CH 3   
                 H 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 pale pink  solid (124-126) 
               
               
                   
               
               
                 2-381 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow oil 
               
               
                   
               
               
                 2-382 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow oil 
               
               
                   
               
               
                 2-383 
                 Cl 
                 H 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow solid (168-170) 
               
               
                   
               
               
                 2-384 
                 Cl 
                 H 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 pale yellow  solid (136-138) 
               
               
                   
               
               
                 2-385 
                 Cl 
                 H 
                 Cl 
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 pink solid (133-135) 
               
               
                   
               
               
                 2-386 
                 Cl 
                 H 
                 Cl 
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 while solid (112-114) 
               
               
                   
               
               
                 2-387 
                 NO 2   
                 H 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 pale yellow  solid (144-146) 
               
               
                   
               
               
                 2-388 
                 NO 2   
                 H 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 orange solid (150-152) 
               
               
                   
               
               
                 2-389 
                 Cl 
                 H 
                 NO 2   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow oil 
               
               
                   
               
               
                 2-390 
                 Cl 
                 H 
                 NO 2   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow solid (115-117) 
               
               
                   
               
               
                 2-391 
                 NO 2   
                 H 
                 Cl 
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 pale yellow  solid (128-130) 
               
               
                   
               
               
                 2-392 
                 NO 2   
                 H 
                 Cl 
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 pale yellow  solid (134-136) 
               
               
                   
               
               
                 2-393 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-394 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-395 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-396 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-397 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-398 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-399 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-400 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-401 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-402 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-403 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-404 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-405 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-406 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-407 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-408 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-409 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-410 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-411 
                 Cl 
                 CH 3 SO 2 CH 2   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-412 
                 Cl 
                 CH 3 SO 2 CH 2   
                 SO 2 CH 3   
                 CH 2 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-413 
                 Cl 
                 CH 3 SO 2 CH 2   
                 SO 2 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 2-414 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow solid (147-149) 
               
               
                   
               
               
                 2-415 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow solid (167-169) 
               
               
                   
               
               
                 2-416 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow oil 
               
               
                   
               
               
                 2-417 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow solid (110-111) 
               
               
                   
               
               
                 2-418 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow solid (101-103) 
               
               
                   
               
               
                 2-419 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow oil 
               
               
                   
               
               
                 2-420 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow solid (105-106) 
               
               
                   
               
               
                 2-421 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 pink oil 
               
               
                   
               
            
           
         
       
     
     In the compound of the formula I, W is N and the stereo configuration is trans. 
     
       
         
         
             
             
         
       
     
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 Structures and Physical Properties of Part of Compounds of Formula I 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 Appear- 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ance 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (Melting 
               
               
                 Com- 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 Point 
               
               
                 pound 
                 X 1   
                 X 3   
                 Z 1   
                 Z 2   
                 R 1   
                 R 2   
                 R 3   
                 R 4   
                 R 5   
                 ° C.) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 3-1 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-2 
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-3 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-4 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 Cl 
                 H 
                 Cl 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-5 
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 Cl 
                 H 
                 Cl 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-6 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 Cl 
                 H 
                 Cl 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-7 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 OCH 3   
                 H 
                 H 
                   
               
               
                   
               
               
                 3-8 
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 OCH 3   
                 H 
                 H 
                   
               
               
                   
               
               
                 3-9 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 OCH 3   
                 H 
                 H 
                   
               
               
                   
               
               
                 3-10 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 NO 2   
                 H 
                 H 
                   
               
               
                   
               
               
                 3-11 
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 NO 2   
                 H 
                 H 
                   
               
               
                   
               
               
                 3-12 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 NO 2   
                 H 
                 H 
                   
               
               
                   
               
               
                 3-13 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 CF 3   
                 H 
                 H 
                   
               
               
                   
               
               
                 3-14 
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 CF 3   
                 H 
                 H 
                   
               
               
                   
               
               
                 3-15 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 CF 3   
                 H 
                 H 
                   
               
               
                   
               
               
                 3-16 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 H 
                 OCF 3   
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-17 
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 OCF 3   
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-18 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 OCF 3   
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-19 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-20 
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-21 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 3-22 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-23 
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-24 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-25 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-26 
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-27 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-28 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-29 
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-30 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 3-31 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-32 
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-33 
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 3-34 
                 NO 2   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-35 
                 NO 2   
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-36 
                 NO 2   
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 3-37 
                 NO 2   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-38 
                 NO 2   
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-39 
                 NO 2   
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 3-40 
                 NO 2   
                 Cl 
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-41 
                 NO 2   
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-42 
                 NO 2   
                 Cl 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-43 
                 Cl 
                 Cl 
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-44 
                 Cl 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-45 
                 Cl 
                 Cl 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 3-46 
                 Cl 
                 Cl 
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-47 
                 Cl 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-48 
                 Cl 
                 Cl 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 3-49 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-50 
                 Cl 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-51 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 3-52 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-53 
                 Cl 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-54 
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                   
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 3-55 
                 CH 3   
                   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-56 
                 CH 3   
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-57 
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-58 
                 CN 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-59 
                 CN 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-60 
                 CN 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-61 
                 CF 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-62 
                 CF 3   
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-63 
                 CF 3   
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-64 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-65 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-66 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-67 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-68 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-69 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-70 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-71 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-72 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-73 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-74 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-75 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-76 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-77 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-78 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-79 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-80 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-81 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-82 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-83 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-84 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-85 
                 SO2CH═CH 2   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-86 
                 SO2CH═CH 2   
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-87 
                 SO2CH═CH 2   
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-88 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-89 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-90 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-91 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-92 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-93 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-94 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-95 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-96 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-97 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-98 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-99 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-100 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-101 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-102 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-103 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-104 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-105 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-106 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-107 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                   
               
               
                 3-108 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 H 
                 H 
                 H 
                 H 
                   
               
               
                   
               
               
                 3-109 
                 H 
                 Cl 
                 CH 3   
                 CH 3   
                 H 
                 H 
                 H 
                 H 
                 H 
                 white  
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 (115- 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 120) 
               
               
                   
               
            
           
         
       
     
     In the compound of the formula I, W is N. 
     
       
         
         
             
             
         
       
     
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 Structures and Physical Properties of Part of Compounds of Formula I 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                   
                 Appearance 
               
               
                   
                   
                   
                   
                   
                   
                 (Melting 
               
               
                 Compound 
                 X 1   
                 X 3   
                 R 1   
                 R 2   
                 Z 
                 Point ° C.) 
               
               
                   
               
               
                 4-1  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-2  
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-3  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-4  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-5  
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-6  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-7  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-8  
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-9  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-10  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-11  
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-12  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-13  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-14  
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-15  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-16  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-17  
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-18  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-19  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-20  
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-21  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-22  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-23  
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-24  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-25  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-26  
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-27  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-28  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-29  
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-30  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-31  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-32  
                 SO 2 CH 3   
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-33  
                 SO 2 CH 3   
                 CF 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-34  
                 NO 2   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-35  
                 NO 2   
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-36  
                 NO 2   
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-37  
                 NO 2   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-38  
                 NO 2   
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-39  
                 NO 2   
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-40  
                 NO 2   
                 Cl 
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-41  
                 NO 2   
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-42  
                 NO 2   
                 Cl 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-43  
                 Cl 
                 Cl 
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-44  
                 Cl 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-45  
                 Cl 
                 Cl 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-46  
                 Cl 
                 Cl 
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-47  
                 Cl 
                 Cl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-48  
                 Cl 
                 Cl 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-49  
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-50  
                 Cl 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-51  
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-52  
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-53  
                 Cl 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-54  
                 Cl 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-55  
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-56  
                 CH 3   
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-57  
                 CH 3   
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-58  
                 CN 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-59  
                 CN 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-60  
                 CN 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-61  
                 CF 3   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-62  
                 CF 3   
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-63  
                 CF 3   
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-64  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-65  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-66  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-67  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-68  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-69  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-70  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-71  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-72  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-73  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-74  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-75  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-76  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-77  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-78  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-79  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-80  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-81  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-82  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-83  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-84  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-85  
                 SO 2 CH═CH 2   
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-86  
                 SO 2 CH═CH 2   
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-87  
                 SO 2 CH═CH 2   
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-88  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-89  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-90  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-91  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-92  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-93  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-94  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-95  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-96  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-97  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-98  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-99  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-100 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-101 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-102 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-103 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-104 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-105 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-106 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-107 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-108 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 SO 2 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-109 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-110 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-111 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-112 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-113 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-114 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-115 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-116 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-117 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-118 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-119 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-120 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-121 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-122 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-123 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-124 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-125 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-126 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-127 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-128 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-129 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-130 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-131 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-132 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-133 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-134 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-135 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-136 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-137 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-138 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-139 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 CF 3   
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   
               
               
                   
               
               
                 4-140 
                 H 
                 Cl 
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 white solid (122-126) 
               
               
                   
               
               
                 4-141 
                 H 
                 Cl 
                 CH 3   
                 CH 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 yellow solid (105-109) 
               
               
                   
               
               
                   1 H NMR data of part of compounds is as follows: 
               
            
           
         
       
     
     Compound 1-1 (600 MHz, DMSO-d 6 ): 8.11 (s, 2H), 7.63-7.67 (m, 3H), 7.42-7.51 (m, 4H), 6.28 (d, 1H), 3.57 (s, 3H), 3.34 (s, 3H), 2.33 (s, 3H). 
     Compound 1-7 (600 MHz, CDCl 3 ): 8.18 (s, 1H), 7.81 (d, 1H), 7.45 (d, 1H), 7.37 (d, 1H), 6.96 (dd, 1H), 6.90 (s, 1H), 6.82 (d, 1H), 6.03 (s, 2H), 5.76 (d, 1H), 3.57 (s, 3H), 3.26 (s, 3H), 2.42 (s, 3H). 
     Compound 1-16 (600 MHz, CDCl 3 ): 8.03 (d, 1H), 7.59 (d, 1H), 7.37-7.48 (m, 6H), 6.09 (d, 1H), 4.98 (s, 2H), 3.61 (s, 3H), 3.47 (s, 3H), 2.81 (s, 3H), 2.47 (s, 3H). 
     Compound 1-18 (600 MHz, DMSO-d 6 ): 7.98 (d, 1H), 7.56-7.65 (m, 4H), 6.98 (d, 2H), 6.15 (d, 1H), 4.86 (s, 2H), 3.82 (s, 3H), 3.57 (s, 3H), 3.34 (s, 3H), 2.94 (s, 3H), 2.35 (s, 3H). 
     Compound 1-20 (600 MHz, DMSO-d 6 ): 7.98 (d, 1H), 7.90 (d, 2H), 7.78 (d, 2H), 7.70 (d, 1H), 7.60 (d, 1H), 6.50 (d, 1H), 4.84 (s, 2H), 3.60 (s, 3H), 3.32 (s, 3H), 3.01 (s, 3H), 2.34 (s, 3H). 
     Compound 1-21 (600 MHz, DMSO-d 6 ): 8.00 (d, 1H), 7.74-7.79 (m, 6H), 7.68 (d, 1H), 7.61 (d, 1H), 7.50 (t, 2H), 7.42 (t, 1H), 6.38 (d, 1H), 4.86 (s, 2H), 3.60 (s, 3H), 3.34 (s, 3H), 2.97 (s, 3H), 2.34 (s, 3H). 
     Compound 1-22 (600 MHz, DMSO-d 6 ): 7.98 (d, 1H), 7.58 (d, 1H), 7.52 (d, 1H), 7.33 (s, 1H), 7.19 (d, 1H), 6.97 (d, 1H), 6.18 (d, 1H), 6.11 (s, 2H), 4.86 (s, 2H), 3.57 (s, 3H), 3.35 (s, 3H), 2.99 (s, 3H), 2.34 (s, 3H). 
     Compound 1-31 (600 MHz, CDCl 3 ): 8.01 (d, 1H), 7.63 (d, 1H), 7.44-7.49 (m, 5H), 7.28 (d, 1H), 6.03 (d, 1H), 3.62 (s, 3H), 2.84 (s, 3H), 2.67 (s, 3H), 2.45 (s, 3H). 
     Compound 1-37 (600 MHz, DMSO-d 6 ): 7.92 (d, 1H), 7.55 (d, 1H), 7.42 (d, 11H), 7.37 (s, 1H), 7.22 (d, 1H), 6.98 (d, 1H), 6.21 (d, 1H), 6.11 (s, 2H), 3.56 (s, 3H), 2.99 (s, 3H), 2.59 (s, 3H), 2.33 (s, 3H). 
     Compound 1-42 (600 MHz, CDCl 3 ): 8.05 (d, 1H), 7.71 (t, 2H), 7.35 (d, 1H), 7.06 (s, 1H), 7.05 (s, 1H), 6.86 (d, 1H), 6.18 (d, 1H), 6.06 (s, 2H), 3.74 (s, 3H), 3.03 (s, 3H), 2.76 (s, 3H). 
     Compound 1-76 (600 MHz, DMSO-d 6 ): 7.99 (d, 1H), 7.60-7.70 (m, 4H), 7.43-7.51 (m, 3H), 6.34 (d, 1H), 4.95 (s, 2H), 3.65 (t, 2H), 3.60 (s, 3H), 3.47 (t, 2H), 3.23 (s, 3H), 2.99 (s, 3H), 2.34 (s, 3H). 
     Compound 1-81 (600 MHz, CDCl 3 ): 8.07 (d, 1H), 7.65-7.67 (m, 3H), 7.62 (d, 2H), 7.58 (d, 2H), 7.46-7.48 (m, 2H), 7.39-7.41 (m, 2H), 6.10 (d, J=15.6 Hz, 1H), 5.10 (s, 2H), 3.76-3.78 (m, 2H), 3.62 (s, 3H), 3.58-3.59 (m, 2H), 3.34 (s, 3H), 2.99 (s, 3H), 2.46 (s, 3H). 
     Compound 1-82 (600 MHz, CDCl 3 ): 8.04 (d, 1H), 7.48 (d, 1H), 7.37 (d, 1H), 6.99-7.00 (m, 2H), 6.83 (d, 1H), 6.04 (s, 2H), 5.86 (d, 1H), 5.10 (s, 2H), 3.76-3.78 (m, 2H), 3.60 (s, 3H), 3.58-3.59 (m, 2H), 3.35 (s, 3H), 3.03 (s, 3H), 2.46 (s, 3H). 
     Compound 1-115 (600 MHz, CDCl 3 ): 7.85 (d, 1H), 7.62 (d, 1H), 7.40-7.50 (m, 5H), 7.18 (d, 1H), 6.09 (d, 1H), 4.00 (s, 3H), 3.62 (s, 3H), 2.83 (s, 3H), 2.44 (s, 3H). 
     Compound 1-223 (600 MHz, DMSO-d 6 ): 7.97 (d, 2H), 7.65-7.71 (m, 4H), 7.44-7.48 (m, 31H), 6.40 (d, 1H), 3.60 (s, 3H), 2.93 (s, 3H), 2.32 (s, 3H). 
     Compound 1-226 (600 MHz, DMSO-d 6 ): 8.01 (s, 1H), 7.90 (d, 1H), 7.62 (d, 1H), 7.55 (d, 1H), 7.37 (s, 1H), 7.21 (d, 1H), 6.97 (d, 1H), 6.24 (d, 1H), 6.11 (s, 2H), 3.58 (s, 3H), 2.99 (s, 3H), 2.33 (s, 3H). 
     Compound 1-229 (600 MHz, DMSO-d 6 ): 7.73 (d, 2H), 7.60 (d, 1H), 7.56 (d, 1H), 7.46-7.52 (m, 3H), 7.43 (dd, 1H), 7.36 (d, 1H), 6.39 (d, 1H), 3.59 (s, 3H), 2.33 (s, 3H). 
     Compound 1-232 (600 MHz, DMSO-d 6 ): 7.59 (s, 1H), 7.46 (d, 1H), 7.40-7.43 (m, 2H), 7.34 (d, 1H), 7.22 (d, 1H), 7.00 (d, 1H), 6.23 (d, 1H), 6.12 (s, 2H), 3.57 (s, 3H), 2.32 (s, 3H). 
     Compound 1-235 (600 MHz, DMSO-d 6 ): 8.58 (s, 1H), 8.36 (d, 1H), 7.84 (d, 1H), 7.69 (d, 2H), 7.62 (d, 1H), 7.44-7.51 (m, 3H), 6.37 (d, 1H), 3.58 (s, 3H), 3.01 (s, 3H), 2.35 (s, 3H). 
     Compound 1-238 (600 MHz, DMSO-d 6 ): 8.58 (s, 1H), 8.34 (d, 1H), 7.82 (d, 1H), 7.51 (d, 1H), 7.36 (s, 1H), 7.20 (d, 1H), 6.98 (d, 1H), 6.20 (d, 1H), 6.12 (s, 2H), 3.55 (s, 3H), 3.07 (s, 3H), 2.36 (s, 3H). 
     Compound 1-259 (600 MHz, DMSO-d 6 ): 7.68-7.70 (m, 3H), 7.62 (d, 1H), 7.48 (t, 1H), 7.42-7.44 (m, 2H), 7.23 (d, 1H), 6.40 (d, 1H), 4.01 (t, 2H), 3.62 (t, 2H), 3.59 (s, 3H), 3.30 (s, 3H), 2.88 (s, 3H), 2.34 (s, 3H), 2.17 (s, 3H). 
     Compound 1-262 (600 MHz, CDCl 3 ): 7.78 (d, 1H), 7.44 (d, 1H), 7.13 (d, 1H), 6.93-6.96 (m, 2H), 6.81 (d, 1H), 6.01 (s, 2H), 5.83 (d, 1H), 4.09 (t, 2H), 3.69 (t, 2H), 3.58 (s, 3H), 3.40 (s, 3H), 2.96 (s, 3H), 2.39 (s, 3H), 2.26 (s, 3H). 
     Compound 1-265 (600 MHz, CDCl 3 ): 7.82 (d, 1H), 7.58 (d, 1H), 7.41-7.49 (m, 5H), 7.17 (d, 1H), 6.07 (d, 1H), 3.85 (s, 3H), 3.63 (s, 3H), 2.84 (s, 3H), 2.44 (s, 3H), 2.28 (s, 3H). 
     Compound 1-268 (600 MHz, CDCl 3 ): 7.95 (d, 1H), 7.59 (d, 1H), 7.41-7.48 (m, 5H), 7.22 (d, 1H), 5.98 (d, 1H), 3.61 (s, 3H), 2.81 (s, 3H), 2.52 (s, 3H), 2.42 (s, 3H), 2.23 (s, 3H). 
     Compound 1-280 (600 MHz, CDCl 3 ): 7.78 (d, 1H), 7.55 (d, 1H), 7.39-7.47 (m, 5H), 7.12 (d, 1H), 6.04 (d, 1H), 3.97 (q, 2H), 3.61 (s, 3H), 2.83 (s, 3H), 2.42 (s, 3H), 2.24 (s, 3H), 1.37 (t, 3H). 
     Compound 1-292 (600 MHz, CDCl 3 ): 8.00 (d, 1H), 7.79 (d, 1H), 7.75 (s, 1H), 7.53-7.56 (m, 3H), 7.41-7.47 (m, 3H), 6.40 (d, 1H), 4.54 (t, 2H), 3.75 (s, 3H), 3.29 (brs, 2H), 2.92 (s, 3H), 2.28 (s, 3H). 
     Compound 1-346 (600 MHz, CDCl 3 ): 7.85 (d, 1H), 7.57 (d, 1H), 7.43-7.50 (m, 5H), 7.27 (d, 1H), 6.05 (d, 1H), 4.34 (q, 2H), 3.63 (s, 3H), 2.80 (s, 3H), 2.47 (s, 3H), 2.31 (s, 3H). 
     Compound 1-349 (600 MHz, CDCl 3 ): 7.83 (d, 1H), 7.58 (d, 1H), 7.41-7.49 (m, 5H), 7.17 (d, 1H), 6.05 (d, 1H), 4.27-4.31 (m, 1H), 3.81-3.39 (m, 4H), 3.63 (s, 3H), 2.91 (s, 3H), 2.44 (s, 3H), 2.30 (s, 3H), 1.94-1.99 (m, 1H), 1.84-1.91 (m, 2H), 1.49-1.55 (m, 1H). 
     Compound 1-367 (600 MHz, CDCl 3 ): 8.04 (s, 1H), 7.46-7.60 (m, 7H), 7.33 (d, 1H), 6.06 (d, 1H), 3.58 (s, 3H), 2.47 (s, 3H). 
     Compound 1-370 (600 MHz, CDCl 3 ): 7.82 (d, 1H), 7.52 (d, 1H), 7.43 (d, 2H), 7.17 (d, 1H), 6.92 (d, 2H), 5.88 (d, 1H), 4.10 (t, 2H), 3.86 (s, 3H), 3.69 (t, 2H), 3.61 (s, 3H), 3.42 (s, 3H), 2.91 (s, 3H), 2.44 (s, 3H), 2.29 (s, 3H). 
     Compound 1-371 (600 MHz, CDCl 3 ): 7.93 (d, 1H), 7.50-7.56 (m, 4H), 7.42-7.49 (m, 3H), 7.29 (d, 1H), 6.10 (d, 1H), 3.61 (s, 3H), 3.26 (s, 3H), 2.40 (s, 3H). 
     Compound 1-372 (600 MHz, CDCl 3 ): 7.86 (d, 1H), 7.81 (d, 1H), 7.70 (s, 1H), 7.55-7.57 (m, 2H), 7.41-7.46 (m, 3H), 7.26 (d, 1H), 6.44 (d, 1H), 4.17 (t, 2H), 4.03-4.07 (m, 2H), 3.75 (t, 2H), 3.44 (s, 3H), 3.10 (s, 3H), 2.33 (s, 3H), 1.46 (t, 3H). 
     Compound 1-373 (600 MHz, CDCl 3 ): 7.87 (d, 1H), 7.65 (d, 1H), 7.41-7.51 (m, 5H), 7.19 (d, 1H), 6.11 (d, 1H), 4.32 (t, 2H), 3.79 (t, 2H), 3.62 (s, 3H), 3.57 (q, 2H), 2.89 (s, 3H), 2.43 (s, 3H), 1.22 (t, 3H). 
     Compound 1-374 (600 MHz, CDCl 3 ): 7.87 (d, 1H), 7.64 (d, 1H), 7.41-7.51 (m, 5H), 7.18 (d, 1H), 6.10 (d, 1H), 4.24 (t, 2H), 3.62 (s, 3H), 3.55 (t, 2H), 3.34 (s, 3H), 2.87 (s, 3H), 2.44 (s, 3H), 2.09-2.10 (m, 2H). 
     Compound 1-375 (600 MHz, CDCl 3 ): 7.84 (d, 1H), 7.59 (d, 1H), 7.39-7.49 (m, 5H), 7.15 (d, 1H), 6.07 (d, 1H), 4.15 (t, 2H), 3.60 (s, 3H), 3.41 (t, 2H), 3.32 (s, 3H), 2.82 (s, 3H), 2.43 (s, 3H), 1.88-1.89 (m, 2H), 1.69-1.70 (m, 2H). 
     Compound 1-376 (600 MHz, CDCl 3 ): 7.85 (d, 1H), 7.62 (d, 1H), 7.40-7.50 (m, 5H), 7.15 (d, 1H), 6.08 (d, 1H), 4.10 (td, 2H), 3.61 (s, 3H), 2.84 (s, 3H), 2.44 (s, 3H), 1.84 (p, 2H), 0.99 (t, 3H). 
     Compound 1-377 (600 MHz, CDCl 3 ): 7.89 (d, 1H), 7.66 (d, 1H), 7.40-7.51 (m, 5H), 7.11 (d, 1H), 6.12 (d, 1H), 5.21-5.27 (m, 1H), 3.62 (s, 3H), 2.83 (s, 3H), 2.40 (s, 3H), 1.35 (d, 6H). 
     Compound 2-1 (600 MHz, CDCl 3 ): 7.79 (d, 1H), 7.11 (d, 1H), 6.82-6.84 (m, 1H), 3.91 (s, 3H), 3.57 (s, 3H), 3.21 (s, 3H), 2.47 (s, 3H), 2.23 (s, 3H), 2.21 (q, 2H), 2.00-2.02 (m, 2H), 1.57-1.64 (m, 4H). 
     Compound 2-19 (600 MHz, CDCl 3 ): 7.80 (d, 1H), 7.10 (d, 1H), 6.81-6.83 (m, 1H), 4.07 (q, 2H), 3.56 (s, 3H), 3.22 (s, 3H), 2.47 (s, 3H), 2.21 (s, 3H), 2.19-2.22 (m, 2H), 1.99-2.02 (m, 2H), 1.58-1.63 (m, 4H), 1.48 (t, 3H). 
     Compound 2-37 (600 MHz, CDCl 3 ): 7.84 (d, 1H), 7.22 (d, 1H), 6.85-6.87 (m, 1H), 4.46 (q, 2H), 3.57 (s, 3H), 3.24 (s, 3H), 2.46 (s, 3H), 2.25 (s, 3H), 2.20 (q, 2H), 1.98-2.01 (m, 2H), 1.57-1.64 (m, 4H). 
     Compound 2-55 (600 MHz, CDCl 3 ): 7.80 (d, 1H), 7.12 (d, 1H), 6.85 (t, 1H), 4.18 (t, 2H), 3.80 (t, 2H), 3.57 (s, 3H), 3.47 (s, 3H), 3.26 (s, 3H), 2.45 (s, 3H), 2.26 (s, 3H), 2.19-2.21 (m, 2H), 2.00-2.01 (m, 2H), 1.57-1.63 (m, 4H). 
     Compound 2-57 (600 MHz, CDCl 3 ): 7.78 (d, 1H), 7.09 (d, 1H), 6.68 (t, 1H), 4.15 (t, 2H), 3.78 (t, 2H), 3.56 (s, 3H), 3.45 (s, 3H), 3.24 (s, 3H), 2.50-2.52 (m, 2H), 2.43 (s, 3H), 2.32-2.34 (m, 2H), 2.24 (s, 3H), 1.93-1.95 (m, 2H). 
     Compound 2-61 (600 MHz, CDCl 3 ): 7.84 (d, 1H), 7.72 (s, 1H), 7.22 (d, 1H), 7.12-7.13 (m, 1H), 4.21 (t, 2H), 3.97-4.00 (m, 2H), 3.79 (t, 2H), 3.46 (s, 3H), 3.27 (s, 3H), 2.30 (s, 3H), 2.20-2.21 (m, 2H), 2.19-2.20 (m, 2H), 1.65-1.70 (m, 2H), 1.62-1.64 (m, 2H), 1.43 (t, 3H). 
     Compound 2-63 (600 MHz, CDCl 3 ): 7.82-7.84 (m, 1H), 7.72 (s, 1H), 7.22 (d, 1H), 6.70 (d, 1H), 4.20 (d, 2H), 3.97-4.01 (m, 2H), 3.79 (d, 2H), 3.45 (s, 3H), 3.27 (s, 3H), 2.53-2.60 (m, 4H), 2.32 (s, 3H), 2.00-2.03 (m, 2H), 1.42 (t, 3H). 
     Compound 2-67 (600 MHz, CDCl 3 ): 7.85 (d, 1H), 7.73 (s, 1H), 7.22 (d, 1H), 7.12-7.13 (m, 1H), 4.20 (t, 2H), 3.80 (t, 2H), 3.70 (s, 3H), 3.47 (s, 3H), 3.28 (s, 3H), 2.31 (s, 3H), 2.25-2.28 (m, 2H), 2.20-2.22 (m, 2H), 1.67-1.70 (m, 2H), 1.62-1.65 (m, 2H). 
     Compound 2-73 (600 MHz, CDCb3): 7.81 (d, 1H), 7.11 (d, 1H), 6.82-6.84 (m, 1H), 4.35-4.39 (m, 1H), 4.01 (d, 2H), 3.85-3.97 (m, 2H), 3.56 (s, 3H), 3.26 (s, 3H), 2.45 (s, 3H), 2.26 (s, 3H), 2.19-2.20 (m, 2H), 1.95-2.00 (m, 4H), 1.57-1.63 (m, 6H). 
     Compound 2-121 (600 MHz, CDCl 3 ): 8.01 (d, 1H), 7.75 (s, 1H), 7.50 (d, 1H), 7.10-7.12 (m, 1H), 4.57 (t, 2H), 3.69 (s, 3H), 3.36-3.32 (m, 2H), 3.18 (s, 3H), 2.25-2.28 (m, 5H), 2.09-2.10 (m, 2H), 1.67-1.69 (m, 2H), 1.62-1.63 (m, 2H). 
     Compound 2-123 (600 MHz, CDCl 3 ): 8.01 (d, 1H), 7.76 (s, 1H), 7.51 (d, 1H), 6.95-6.98 (m, 1H), 4.58 (t, 2H), 3.71 (s, 3H), 3.32-3.37 (m, 2H), 3.19 (s, 3H), 2.58-2.62 (m, 2H), 2.52-2.54 (m, 2H), 2.26 (s, 3H), 2.01-2.04 (m, 2H). 
     Compound 2-127 (600 MHz, CDCl 3 ): 7.92 (d, 1H), 7.15 (d, 1H), 6.68-6.69 (m, 1H), 3.55 (s, 3H), 3.05 (s, 3H), 2.61 (s, 3H), 2.49 (s, 3H), 2.19 (s, 3H), 2.16-2.17 (m, 2H), 1.94-1.95 (m, 2H), 1.55-1.65 (m, 4H). 
     Compound 2-145 (600 MHz, CDCl 3 ): 7.95 (d, 1H), 7.26 (d, 1H), 6.69-6.70 (m, 1H), 4.87 (s, 2H), 3.54 (s, 3H), 3.47 (s, 3H), 3.15 (s, 3H), 2.47 (s, 3H), 2.31 (s, 3H), 2.15-2.16 (m, 2H), 1.94-1.95 (m, 2H), 1.56-1.60 (m, 4H). 
     Compound 2-289 (600 MHz, CDCl 3 ): 7.98 (d, 1H), 7.20 (d, 1H), 6.72 (s, 1H), 3.54 (s, 3H), 3.07 (s, 3H), 2.74 (s, 3H), 2.49 (s, 3H), 2.16-2.17 (m, 2H), 1.96-1.97 (m, 2H), 1.55-1.60 (m, 4H). 
     Compound 2-291 (600 MHz, CDCl 3 ): 7.97 (d, 1H), 7.21 (d, 1H), 6.59 (s, 1H), 3.55 (s, 3H), 3.07 (s, 3H), 2.73 (s, 3H), 2.50-2.52 (m, 5H), 2.30-2.32 (m, 2H), 1.91-1.96 (m, 2H). Compound 2-307 (600 MHz, CDCl 3 ): 8.01 (d, 1H), 7.31 (d, 1H), 6.71 (s, 1H), 5.01 (s, 2H), 3.52 (s, 3H), 3.46 (s, 3H), 3.19 (s, 3H), 2.46 (s, 3H), 2.13-2.14 (m, 2H), 1.94-1.95 (m, 2H), 1.54-1.56 (m, 4H). 
     Compound 2-309 (600 MHz, CDCl 3 ): 8.03 (d, 1H), 7.33 (d, 1H), 6.60 (s, 1H), 5.03 (s, 2H), 3.56 (s, 3H), 3.48 (s, 3H), 3.22 (s, 3H), 2.49-2.52 (m, 5H), 2.30-2.33 (m, 2H), 1.91-1.96 (m, 2H). 
     Compound 2-343 (600 MHz, CDCl 3 ): 8.01 (d, 1H), 7.54 (q, 1H), 7.23 (d, 1H), 6.77-6.78 (m, 1H), 3.55 (s, 3H), 3.26 (s, 3H), 2.45 (s, 3H), 2.17 (q, 2H), 2.00-2.01 (m, 2H), 1.56-1.63 (m, 4H). 
     Compound 2-379 (600 MHz, DMSO-d 6 ): 8.22 (s, 1H), 8.16 (d, 1H), 7.61 (d, 1H), 6.58 (s, 1H), 3.51 (s, 3H), 3.32 (s, 3H), 2.36 (s, 3H), 2.02-2.04 (m, 2H), 1.85-1.87 (m, 2H), 1.40-1.50 (m, 4H). 
     Compound 2-380 (600 MHz, DMSO-d 6 ): 8.21 (s, 1H), 8.17 (d, 1H), 7.61 (d, 1H), 6.49 (s, 1H), 3.52 (s, 3H), 3.32 (s, 3H), 2.34-2.36 (m, 5H), 2.20-2.21 (m, 2H), 1.76-1.82 (m, 2H). 
     Compound 2-381 (600 MHz, CDCl 3 ): 8.05 (d, 1H), 7.34 (d, 1H), 6.74 (s, 1H), 5.16 (s, 2H), 3.77 (t, 2H), 3.56 (t, 2H), 3.55 (s, 3H), 3.34 (s, 3H), 3.29 (s, 3H), 2.50 (s, 3H), 2.16-2.17 (m, 2H), 1.98-1.99 (m, 2H), 1.57-1.61 (m, 4H). 
     Compound 2-382 (600 MHz, CDCl 3 ): 8.04 (d, 1H), 7.34 (d, 1H), 6.61 (s, 1H), 5.15 (s, 2H), 3.77 (t, 2H), 3.56-3.58 (m, 5H), 3.34 (s, 3H), 3.29 (s, 3H), 2.50-2.53 (m, 5H), 2.31-2.33 (m, 2H), 1.92-1.97 (m, 2H). 
     Compound 2-383 (600 MHz, CDCh3): 7.91 (s, 1H), 7.79 (d, 1H), 7.37 (d, 1H), 6.77 (s, 1H), 3.54 (s, 3H), 3.03 (s, 3H), 2.47 (s, 3H), 2.15-2.16 (m, 2H), 1.97-1.98 (m, 2H), 1.55-1.58 (m, 4H). 
     Compound 2-384 (600 MHz, CDCl 3 ): 7.93 (s, 1H), 7.81 (d, 1H), 7.40 (d, 1H), 6.67 (s, 1H), 3.58 (s, 3H), 3.07 (s, 3H), 2.49-2.52 (m, 5H), 2.33-2.34 (m, 2H), 1.93-1.96 (m, 2H). 
     Compound 2-385 (600 MHz, CDCl 3 ): 7.36 (s, 1H), 7.22 (d, 1H), 7.15 (d, 1H), 6.87 (s, 1H), 3.57 (s, 3H), 2.47 (s, 3H), 2.20-2.22 (m, 2H), 2.04-2.06 (m, 2H), 1.61-1.63 (m, 4H). 
     Compound 2-386 (600 MHz, CDCl 3 ): 7.36 (d, 1H), 7.24 (dd, 1H), 7.15 (d, 1H), 6.73 (s, 1H), 3.59 (s, 3H), 2.52-2.54 (m, 2H), 2.46 (s, 3H), 2.38-2.42 (m, 2H), 1.94-1.99 (m, 2H). 
     Compound 2-387 (600 MHz, CDCl 3 ): 8.66 (s, 1H), 8.19 (d, 1H), 7.55 (d, 1H), 6.75 (s, 1H), 3.52 (s, 3H), 3.11 (s, 3H), 2.52 (s, 3H), 2.18-2.21 (m, 2H), 1.92-1.93 (m, 2H), 1.57-1.64 (m, 4H). 
     Compound 2-388 (600 MHz, CDCl 3 ): 8.64 (s, 1H), 7.19 (d, 1H), 7.54 (d, 1H), 6.63 (s, 1H), 3.52 (s, 3H), 3.11 (s, 3H), 2.51-2.54 (m, 5H), 2.26-2.28 (m, 2H), 1.92-1.94 (m, 2H). 
     Compound 2-389 (600 MHz, CDCl 3 ): 8.21 (d, 1H), 8.10 (dd, 1H), 7.37 (d, 1H), 6.82 (t, 1H), 3.56 (s, 3H), 2.47 (s, 3H), 2.06-2.08 (m, 2H), 1.98-1.99 (m, 2H), 1.44-1.53 (m, 4H). 
     Compound 2-390 (600 MHz, CDCl 3 ): 8.20 (d, 1H), 8.09 (dd, 1H), 7.38 (d, 1H), 6.69 (s, 1H), 3.57 (s, 3H), 2.44 (s, 3H), 2.38-2.41 (m, 2H), 2.34-2.36 (m, 2H), 1.82-1.88 (m, 2H). 
     Compound 2-391 (600 MHz, CDCl 3 ): 8.09 (s, 1H), 7.63 (d, 1H), 7.28 (d, 1H), 6.83 (s, 1H), 3.52 (s, 3H), 2.51 (s, 3H), 2.20-2.21 (m, 2H), 1.98-1.99 (m, 2H), 1.62-1.64 (m, 4H). 
     Compound 2-392 (600 MHz, CDCl 3 ): 8.08 (s, 1H), 7.63 (d, 1H), 7.29 (d, 1H), 6.71 (s, 1H), 3.54 (s, 3H), 2.53-2.55 (m, 2H), 2.50 (s, 3H), 2.34-2.36 (m, 2H), 1.96-1.99 (m, 2H). 
     Compound 2-414 (600 MHz, CDCl 3 ): 7.83 (d, 1H), 7.07 (d, 1H), 6.90-6.91 (m, 1H), 4.77-4.81 (m, 1H), 3.57 (s, 3H), 3.19 (s, 3H), 2.36 (s, 3H), 2.23 (s, 3H), 2.17-2.20 (m, 2H), 2.05-2.07 (m, 2H), 1.57-1.63 (m, 4H), 1.34 (d, 6H). 
     Compound 2-415 (600 MHz, CDCl 3 ): 7.83 (d, 1H), 7.08 (d, 1H), 6.76-6.77 (m, 1H), 4.76-4.81 (m, 1H), 3.59 (s, 3H), 3.20 (s, 3H), 2.50-2.54 (m, 2H), 2.40-2.43 (m, 2H), 2.37 (s, 3H), 2.24 (s, 3H), 1.93-1.98 (m, 2H), 1.35 (d, 6H). 
     Compound 2-416 (600 MHz, CDCl 3 ): 7.79 (d, 1H), 7.11 (d, 1H), 6.76-6.78 (m, 1H), 4.16 (t, 2H), 3.79 (t, 2H), 3.55-3.59 (m, 4H), 3.47 (s, 3H), 3.24 (s, 3H), 2.24 (s, 3H), 2.17-2.19 (m, 2H), 1.96-1.97 (m, 2H), 1.59-1.63 (m, 4H), 1.32 (d, 6H). 
     Compound 2-417 (600 MHz, CDCl 3 ): 7.79 (d, 1H), 7.11 (d, 1H), 6.79-6.81 (m, 1H), 4.17 (t, 2H), 3.79 (t, 2H), 3.56 (s, 3H), 3.47 (s, 3H), 3.25 (s, 3H), 2.91 (q, 2H), 2.25 (s, 3H), 2.18-2.20 (m, 2H), 1.97-1.99 (m, 2H), 1.59-1.64 (m, 4H), 1.28 (t, 3H). 
     Compound 2-418 (600 MHz, CDCl 3 ): 7.81 (d, 1H), 7.16 (d, 1H), 7.09 (t, 1H), 6.86-6.87 (m, 1H), 4.17 (t, 2H), 3.79 (t, 2H), 3.69 (s, 3H), 3.47 (s, 3H), 3.26 (s, 3H), 2.27 (s, 3H), 2.18-2.20 (m, 2H), 1.98-2.00 (m, 2H), 1.59-1.63 (m, 4H). 
     Compound 2-419 (600 MHz, CDCl 3 ): 7.80 (d, 1H), 7.15 (d, 1H), 6.86-6.87 (m, 1H), 4.17 (t, 2H), 3.79 (t, 2H), 3.52 (s, 3H), 3.47 (s, 3H), 3.25 (s, 3H), 2.34-2.39 (m, 1H), 2.28 (s, 3H), 2.18-2.21 (m, 2H), 2.02-2.04 (m, 2H), 1.58-1.64 (m, 4H), 0.89-0.98 (m, 4H). 
     Compound 2-420 (600 MHz, CDCl 3 ): 7.80 (d, 1H), 7.12 (d, 1H), 6.85-6.87 (m, 1H), 4.17 (t, 2H), 3.85 (q, 2H), 3.79 (t, 2H), 3.47 (s, 3H), 3.25 (s, 3H), 2.44 (s, 3H), 2.26 (s, 3H), 2.19-2.21 (m, 2H), 2.02-2.04 (m, 2H), 1.57-1.62 (m, 4H), 1.38 (t, 3H). 
     Compound 2-421 (600 MHz, CDCl 3 ): 8.02 (d, 1H), 7.31 (d, 1H), 6.72-6.73 (m, 1H), 5.14 (s, 2H), 4.04-4.05 (m, 1H), 3.79-3.80 (m, 1H), 3.72-3.73 (m, 1H), 3.62-3.65 (m, 2H), 3.53 (s, 3H), 3.27 (s, 3H), 2.48 (s, 3H), 2.15-2.17 (m, 2H), 1.97-2.00 (m, 2H), 1.91-1.92 (m, 1H), 1.84-1.87 (m, 2H), 1.57-1.60 (m, 5H). 
     Compound 3-109 (600 MHz, CDCl 3 ): 8.64 (d, 1H), 7.88-7.92 (m, 1H), 7.63 (d, 1H), 7.51 (d, 2H), 7.39-7.47 (m, 3H), 7.33 (d, 1H), 6.22 (d, 1H), 3.67 (s, 3H), 2.40 (s, 3H). 
     Compound 4-140 (600 MHz, CDCl 3 ): 8.54 (d, 1H), 7.81-7.85 (m, 1H), 7.35 (d, 1H), 6.91-6.97 (m, 1H), 3.62 (s, 3H), 2.42 (s, 3H), 2.18-2.24 (m, 2H), 2.01-2.06 (m, 2H), 1.55-1.64 (m, 4H). 
     Compound 4-141 (600 MHz, CDCl 3 ): 8.56 (d, 1H), 7.83-7.87 (m, 1H), 7.35 (d, 1H), 6.80-6.85 (m, 1H), 3.62 (s, 3H), 2.50-2.55 (m, 2H), 2.38-2.43 (m, 5H), 1.89-2.00 (m, 2H). 
     Biometric Test Examples 
     Embodiment 4 Determination of Herbicidal Activity 
     Seeds of broadleaf weeds (zinnia and piemarker) or grassy weeds (green bristlegrass and barnyard grass) were respectively sown in a paper cup having a diameter of 7 cm and containing nutrient soil; after sowing, the seeds were covered with 1 cm of soil, the soil was pressed and watered, and then the seeds were cultivated in a greenhouse according to a conventional method; and stems and leaves were sprayed after 2-3 leaf stage of the weeds. 
     After the original medicinal acetone was dissolved, the test requires to use 1‰ of Tween 80 to stand in running water to prepare the solution to be tested with a required concentration. According to the design dose of the test, spray treatment was carried out on a track-type crop sprayer (designed and produced by British Engineer Research Ltd.) (spray pressure is 1.95 kg/cm 2 , spray volume is 500 L/hm 2  and track speed is 1.48 km/h). The test was repeated for three times. The test material was treated and then placed in an operation hall. The medicinal liquid was naturally dried in the shade, and then was placed in a greenhouse and managed according to the conventional method. The response of the weeds to the drug was observed and recorded. After treatment, the control effects of the test drug on the weeds were visually inspected regularly, expressed by 0-100%. “0” represents no control effect and “100%4” represents complete killing. 
     The test results show that the compounds of the formula I generally have high control effects on various weeds. Part of the test compounds, such as compounds 1-1, 1-7, 1-18, 1-20, 1-42, 1-76, 1-81, 1-82, 1-226, 1-259, 1-262, 1-265, 1-280, 1-292, 1-346, 1-349, 1-367, 1-370, 1-371, 2-1, 2-19, 2-37, 2-55, 2-67, 2-73, 2-121, 2-123, 2-289, 2-291, 2-307, 2-309, 2-379, 2-380, 2-383, 2-386, 2-391, 2416, 2417, 2-418, 2-419 and 2420, have good control effects on zinnia, piemarker, green bristlegrass or barnyard grass at the application dose of 600 g a.i./hm 2 , and the control effects are greater than or equal to 90%. 
     According to the above test method, part of the compounds of the formula I and KC 1  are selected for activity test of controlling the zinnia. The results are shown in Table 5. 
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 Zinnia Control Activity of Part of Compounds of Formula 1  
               
               
                 and Reference Compound KC 1  (after emergence, control effect %) 
               
            
           
           
               
               
            
               
                   
                 dose g a.i./hm 2   
               
            
           
           
               
               
               
               
            
               
                 Compound 
                 600 
                 150 
                 37.5 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 1-42 
                 100 
                 100 
                 100 
               
               
                 1-81 
                 100 
                 95 
                 90 
               
               
                 KC 1   
                 0 
                 0 
                 0 
               
               
                   
               
            
           
         
       
     
     According to the above test method, part of the compounds of the formula and KC 1  are selected for activity test of controlling the piemarker. The results are shown in Table 6. 
     
       
         
           
               
             
               
                 TABLE 6 
               
             
            
               
                   
               
               
                 Piemarker Control Activity of Part of Compounds  
               
               
                 of Formula 1 and Reference Compound KC 1   
               
               
                 (after emergence, control effect %) 
               
            
           
           
               
               
            
               
                   
                 dose g a.i./hm 2   
               
            
           
           
               
               
               
               
            
               
                 Compound 
                 600 
                 150 
                 37.5 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 1-1 
                 100 
                 95 
                 90 
               
               
                 1-42 
                 100 
                 95 
                 90 
               
               
                 1-259 
                 / 
                 100 
                 100 
               
               
                 1 -292 
                 95 
                 90 
                 90 
               
               
                 KC 1   
                 100 
                 70 
                 20 
               
               
                   
               
               
                 “/” in the table indicates no test. 
               
            
           
         
       
     
     According to the above test method, part of the compounds of the formula I and KC 1  or KC 2  are selected for activity test of controlling the green bristlegrass. The results are shown in Table 7. 
     
       
         
           
               
             
               
                 TABLE 7 
               
             
            
               
                   
               
               
                 Green Bristlegrass Control Activity of Part of Compounds  
               
               
                 of Formula 1 and Reference Compounds KC 1  or KC 2   
               
               
                 (after emergence, control effect %) 
               
            
           
           
               
               
               
            
               
                   
                   
                 dose g a.i./hm 2   
               
            
           
           
               
               
               
               
               
            
               
                   
                 Compound 
                 600 
                 150 
                 37.5 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 1-259 
                 / 
                 100 
                 100 
               
               
                   
                 1-280 
                 100 
                 90 
                 80 
               
               
                   
                 1 -292 
                 95 
                 90 
                 90 
               
               
                   
                 KC 1   
                 10 
                 10 
                 10 
               
               
                   
                 2-121 
                 98 
                 90 
                 80 
               
               
                   
                 2-123 
                 100 
                 100 
                 90 
               
               
                   
                 KC 2   
                 / 
                 60 
                 30 
               
               
                   
                   
               
               
                   
                 “/” in the table indicates no test. 
               
            
           
         
       
     
     According to the above test method, part of the compounds of the formula I and KC 1  or KC 2  are selected for activity test of controlling the barnyard grass. The results are shown in Table 8. 
     
       
         
           
               
             
               
                 TABLE 8 
               
             
            
               
                   
               
               
                 Barnyard Grass Control Activity of Part of Compounds  
               
               
                 of Formula 1 and Reference Compounds KC 1  or KC 2   
               
               
                 (after emergence, control effect %) 
               
            
           
           
               
               
            
               
                   
                 dose g a.i./hm 2   
               
            
           
           
               
               
               
               
            
               
                 Compound 
                 600 
                 150 
                 37.5 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 1-42 
                 100 
                 95 
                 80 
               
               
                 1-81 
                 95 
                 90 
                 80 
               
               
                 1-82 
                 100 
                 95 
                 90 
               
               
                 1-259 
                 / 
                 100 
                 100 
               
               
                 1-280 
                 100 
                 95 
                 85 
               
               
                 1-292 
                 100 
                 95 
                 90 
               
               
                 KC 1   
                 0 
                 0 
                 0 
               
               
                 2.37 
                 100 
                 100 
                 95 
               
               
                 2-67 
                 100 
                 100 
                 90 
               
               
                 2-73 
                 100 
                 100 
                 95 
               
               
                 2-123 
                 100 
                 100 
                 100 
               
               
                 KC 2   
                 / 
                 90 
                 60 
               
               
                   
               
               
                 “/” in the table indicates no test. 
               
            
           
         
       
     
     To sum up, the alkene-containing carboxylic ester compound of the present invention has excellent herbicidal activity, also has high herbicidal activity at a lower dosage, and can be used for agriculturally controlling various weeds.