Patent Publication Number: US-2019170767-A1

Title: Compositions, devices, and methods of ulcerative colitis sensitivity testing

Description:
RELATED APPLICATIONS 
     This application is a Continuation of International Application No. PCT/US2017/028696, filed Apr. 20, 2017, which claims priority to U.S. Provisional Patent Application No. 62/327,932 filed Apr. 26, 2016, and entitled “Compositions, Devices, And Methods Of Ulcerative Colitis Sensitivity Testing.” Each of the foregoing applications is incorporated herein by reference in its entirety. 
    
    
     FIELD OF THE INVENTION 
     The field of the invention is sensitivity testing for food intolerance, and especially as it relates to testing and possible elimination of selected food items as trigger foods for patients diagnosed with or suspected to have Ulcerative Colitis. 
     BACKGROUND 
     The background description includes information that may be useful in understanding the present invention. It is not an admission that any of the information provided herein is prior art or relevant to the presently claimed invention, or that any publication specifically or implicitly referenced is prior art. 
     Food sensitivity, especially as it relates to Ulcerative Colitis (a type of inflammatory bowel disease), often presents with diarrhea mixed with blood and mucus and underlying causes of Ulcerative Colitis are not well understood in the medical community. Most typically, Ulcerative Colitis is diagnosed by endoscopic and radiological tests, along with blood tests or electrolyte tests to identify inflammatory conditions. Unfortunately, treatment of Ulcerative Colitis is often less than effective and may present new difficulties due to immune suppressive or modulatory effects. Elimination of other one or more food items has also shown promise in at least reducing incidence and/or severity of the symptoms. However, Ulcerative Colitis is often quite diverse with respect to dietary items triggering symptoms, and no standardized test to help identify trigger food items with a reasonable degree of certainty is known, leaving such patients often to trial-and-error. 
     While there are some commercially available tests and labs to help identify trigger foods, the quality of the test results from these labs is generally poor as is reported by a consumer advocacy group (e.g., http://www.which.co.uk/news/2008/08/food-allergy-tests-could-risk-your-health-154711/). Most notably, problems associated with these tests and labs were high false positive rates, high false negative rates, high intra-patient variability, and inter-laboratory variability, rendering such tests nearly useless. Similarly, further inconclusive and highly variable test results were also reported elsewhere (Alternative Medicine Review, Vol. 9, No. 2, 2004: pp 198-207), and the authors concluded that this may be due to food reactions and food sensitivities occurring via a number of different mechanisms. For example, not all Ulcerative Colitis patients show positive response to food A, and not all Ulcerative Colitis patients show negative response to food B. Thus, even if an Ulcerative Colitis patient shows positive response to food A, removal of food A from the patient&#39;s diet may not relieve the patient&#39;s Ulcerative Colitis symptoms. In other words, it is not well determined whether food samples used in the currently available tests are properly selected based on the high probabilities to correlate sensitivities to those food samples to Ulcerative Colitis. 
     All publications identified herein are incorporated by reference to the same extent as if each individual publication or patent application were specifically and individually indicated to be incorporated by reference. Where a definition or use of a term in an incorporated reference is inconsistent or contrary to the definition of that term provided herein, the definition of that term provided herein applies and the definition of that term in the reference does not apply. 
     Thus, even though various tests for food sensitivities are known in the art, all or almost all of them suffer from one or more disadvantages. Therefore, there is still a need for improved compositions, devices, and methods of food sensitivity testing, especially for identification and possible elimination of trigger foods for patients identified with or suspected of having Ulcerative Colitis. 
     SUMMARY 
     The subject matter described herein provides systems and methods for testing food intolerance in patients diagnosed with or suspected to have Ulcerative Colitis. One aspect of the disclosure is a test kit with for testing food intolerance in patients diagnosed with or suspected to have Ulcerative Colitis. The test kit includes a plurality of distinct food preparations coupled to individually addressable respective solid carriers. The plurality of distinct food preparations have an average discriminatory p-value of ≤0.07 as determined by raw p-value or an average discriminatory p-value of ≤0.10 as determined by FDR multiplicity adjusted p-value. In some embodiments, the average discriminatory p-value is determined by a process, which includes comparing assay values of a first patient test cohort that is diagnosed with or suspected of having Ulcerative Colitis with assay values of a second patient test cohort that is not diagnosed with or suspected of having Ulcerative Colitis. 
     Another aspect of the embodiments described herein includes a method of testing food intolerance in patients diagnosed with or suspected to have Ulcerative Colitis. The method includes a step of contacting a food preparation with a bodily fluid of a patient that is diagnosed with or suspected to have Ulcerative Colitis. The bodily fluid is associated with gender identification. In certain embodiments, the step of contacting is performed under conditions that allow IgG from the bodily fluid to bind to at least one component of the food preparation. The method continues with a step of measuring IgG bound to the at least one component of the food preparation to obtain a signal, and then comparing the signal to a gender-stratified reference value for the food preparation using the gender identification to obtain a result. Then, the method also includes a step of updating or generating a report using the result. 
     Another aspect of the embodiments described herein includes a method of generating a test for food intolerance in patients diagnosed with or suspected to have Ulcerative Colitis. The method includes a step of obtaining test results for a plurality of distinct food preparations. The test results are based on bodily fluids of patients diagnosed with or suspected to have Ulcerative Colitis and bodily fluids of a control group not diagnosed with or not suspected to have Ulcerative Colitis. The method also includes a step of stratifying the test results by gender for each of the distinct food preparations. Then the method continues with a step of assigning for a predetermined percentile rank a different cutoff value for male and female patients for each of the distinct food preparations. 
     Still another aspect of the embodiments described herein includes a use of a plurality of distinct food preparations coupled to individually addressable respective solid carriers in a diagnosis of Ulcerative Colitis. The plurality of distinct food preparations are selected based on their average discriminatory p-value of ≤0.07 as determined by raw p-value or an average discriminatory p-value of ≤0.10 as determined by FDR multiplicity adjusted p-value. 
     Various objects, features, aspects and advantages of the embodiments described herein will become more apparent from the following detailed description of preferred embodiments, along with the accompanying drawing figures in which like numerals represent like components. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       Table 1 shows a list of food items from which food preparations can be prepared. 
       Table 2 shows statistical data of foods ranked according to 2-tailed FDR multiplicity-adjusted p-values. 
       Table 3 shows statistical data of ELISA score by food and gender. 
       Table 4 shows cutoff values of foods for a predetermined percentile rank. 
         FIG. 1A  illustrates ELISA signal score of male Ulcerative Colitis patients and control tested with green pea. 
         FIG. 1B  illustrates a distribution of percentage of male Ulcerative Colitis subjects exceeding the 90 th  and 95 th  percentile tested with green pea. 
         FIG. 1C  illustrates a signal distribution in women along with the 95 th  percentile cutoff as determined from the female control population tested with green pea. 
         FIG. 1D  illustrates a distribution of percentage of female Ulcerative Colitis subjects exceeding the 90 th  and 95 th  percentile tested with green pea. 
         FIG. 2A  illustrates ELISA signal score of male Ulcerative Colitis patients and control tested with cantaloupe. 
         FIG. 2B  illustrates a distribution of percentage of male Ulcerative Colitis subjects exceeding the 90 th  and 95 th  percentile tested with cantaloupe. 
         FIG. 2C  illustrates a signal distribution in women along with the 95 th  percentile cutoff as determined from the female control population tested with cantaloupe. 
         FIG. 2D  illustrates a distribution of percentage of female Ulcerative Colitis subjects exceeding the 90 th  and 95 th  percentile tested with cantaloupe. 
         FIG. 3A  illustrates ELISA signal score of male Ulcerative Colitis patients and control tested with pinto bean. 
         FIG. 3B  illustrates a distribution of percentage of male Ulcerative Colitis subjects exceeding the 90 th  and 95 th  percentile tested with pinto bean. 
         FIG. 3C  illustrates a signal distribution in women along with the 95 th  percentile cutoff as determined from the female control population tested with pinto bean. 
         FIG. 3D  illustrates a distribution of percentage of female Ulcerative Colitis subjects exceeding the 90 th  and 95 th  percentile tested with pinto bean. 
         FIG. 4A  illustrates ELISA signal score of male Ulcerative Colitis patients and control tested with cucumber. 
         FIG. 4B  illustrates a distribution of percentage of male Ulcerative Colitis subjects exceeding the 90 th  and 95 th  percentile tested with cucumber. 
         FIG. 4C  illustrates a signal distribution in women along with the 95 th  percentile cutoff as determined from the female control population tested with cucumber. 
         FIG. 4D  illustrates a distribution of percentage of female Ulcerative Colitis subjects exceeding the 90 th  and 95 th  percentile tested with cucumber. 
         FIG. 5A  illustrates distributions of Ulcerative Colitis subjects by number of foods that were identified as trigger foods at the 90 th  percentile. 
         FIG. 5B  illustrates distributions of Ulcerative Colitis subjects by number of foods that were identified as trigger foods at the 95 th  percentile. 
       Table 5A shows raw data of Ulcerative Colitis patients and control with number of positive results based on the 90 th  percentile. 
       Table 5B shows raw data of Ulcerative Colitis patients and control with number of positive results based on the 95 th  percentile. 
       Table 6A shows statistical data summarizing the raw data of Ulcerative Colitis patient populations shown in Table 5A. 
       Table 6B shows statistical data summarizing the raw data of Ulcerative Colitis patient populations shown in Table 5B. 
       Table 7A shows statistical data summarizing the raw data of control populations shown in Table 5A. 
       Table 7B shows statistical data summarizing the raw data of control populations shown in Table 5B. 
       Table 8A shows statistical data summarizing the raw data of Ulcerative Colitis patient populations shown in Table 5A transformed by logarithmic transformation. 
       Table 8B shows statistical data summarizing the raw data of Ulcerative Colitis patient populations shown in Table 5B transformed by logarithmic transformation. 
       Table 9A shows statistical data summarizing the raw data of control populations shown in Table 5A transformed by logarithmic transformation. 
       Table 9B shows statistical data summarizing the raw data of control populations shown in Table 5B transformed by logarithmic transformation. 
       Table 10A shows statistical data of an independent T-test to compare the geometric mean number of positive foods between the Ulcerative Colitis and non-Ulcerative Colitis samples based on the 90 th  percentile. 
       Table 10B shows statistical data of an independent T-test to compare the geometric mean number of positive foods between the Ulcerative Colitis and non-Ulcerative Colitis samples based on the 95 th  percentile. 
       Table 11A shows statistical data of a Mann-Whitney test to compare the geometric mean number of positive foods between the Ulcerative Colitis and non-Ulcerative Colitis samples based on the 90 th  percentile. 
       Table 11B shows statistical data of a Mann-Whitney test to compare the geometric mean number of positive foods between the Ulcerative Colitis and non-Ulcerative Colitis samples based on the 95 th  percentile. 
         FIG. 6A  illustrates a box and whisker plot of data shown in Table 5A. 
         FIG. 6B  illustrates a notched box and whisker plot of data shown in Table 5A. 
         FIG. 6C  illustrates a box and whisker plot of data shown in Table 5B. 
         FIG. 6D  illustrates a notched box and whisker plot of data shown in Table 5B. 
       Table 12A shows statistical data of a Receiver Operating Characteristic (ROC) curve analysis of data shown in Tables 5A-11A. 
       Table 12B shows statistical data of a Receiver Operating Characteristic (ROC) curve analysis of data shown in Tables 5B-11B. 
         FIG. 7A  illustrates the ROC curve corresponding to the statistical data shown in Table 12A. 
         FIG. 7B  illustrates the ROC curve corresponding to the statistical data shown in Table 12B. 
       Table 13A shows a statistical data of performance metrics in predicting Ulcerative Colitis status among female patients from number of positive foods based on the 90 th  percentile. 
       Table 13B shows a statistical data of performance metrics in predicting Ulcerative Colitis status among male patients from number of positive foods based on the 90 th  percentile. 
       Table 14A shows a statistical data of performance metrics in predicting Ulcerative Colitis status among female patients from number of positive foods based on the 95 th  percentile. 
       Table 14B shows a statistical data of performance metrics in predicting Ulcerative Colitis status among male patients from number of positive foods based on the 95 th  percentile. 
     
    
    
     DETAILED DESCRIPTION 
     The inventors have discovered that food preparations used in food tests to identify trigger foods in patients diagnosed with or suspected to have Ulcerative Colitis are not equally well predictive and/or associated with Ulcerative Colitis/Ulcerative Colitis symptoms. Indeed, various experiments have revealed that among a wide variety of food items certain food items are highly predictive/associated with Ulcerative Colitis whereas others have no statistically significant association with Ulcerative Colitis. 
     Even more unexpectedly, the inventors discovered that in addition to the high variability of food items, gender variability with respect to response in a test plays a substantial role in the determination of association or a food item with Ulcerative Colitis. Consequently, based on the inventors&#39; findings and further contemplations, test kits and methods are now presented with substantially higher predictive power in the choice of food items that could be eliminated for reduction of Ulcerative Colitis signs and symptoms. 
     The following discussion provides many example embodiments of the inventive subject matter. Although each embodiment represents a single combination of inventive elements, the inventive subject matter is considered to include all possible combinations of the disclosed elements. Thus if one embodiment comprises elements A, B, and C, and a second embodiment comprises elements B and D, then the inventive subject matter is also considered to include other remaining combinations of A, B, C, or D, even if not explicitly disclosed. 
     In some embodiments, the numbers expressing quantities or ranges, used to describe and claim certain embodiments of the invention are to be understood as being modified in some instances by the term “about.” Accordingly, in some embodiments, the numerical parameters set forth in the written description and attached claims are approximations that can vary depending upon the desired properties sought to be obtained by a particular embodiment. In some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable. The numerical values presented in some embodiments of the invention may contain certain errors necessarily resulting from the standard deviation found in their respective testing measurements. Unless the context dictates the contrary, all ranges set forth herein should be interpreted as being inclusive of their endpoints and open-ended ranges should be interpreted to include only commercially practical values. Similarly, all lists of values should be considered as inclusive of intermediate values unless the context indicates the contrary. 
     As used in the description herein and throughout the claims that follow, the meaning of “a,” “an,” and “the” includes plural reference unless the context clearly dictates otherwise. Also, as used in the description herein, the meaning of “in” includes “in” and “on” unless the context clearly dictates otherwise. 
     All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g., “such as”) provided with respect to certain embodiments herein is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention otherwise claimed. No language in the specification should be construed as indicating any non-claimed element essential to the practice of the invention. 
     Groupings of alternative elements or embodiments of the invention disclosed herein are not to be construed as limitations. Each group member can be referred to and claimed individually or in any combination with other members of the group or other elements found herein. One or more members of a group can be included in, or deleted from, a group for reasons of convenience and/or patentability. When any such inclusion or deletion occurs, the specification is herein deemed to contain the group as modified thus fulfilling the written description of all Markush groups used in the appended claims. 
     In one aspect, the inventors therefore contemplate a test kit or test panel that is suitable for testing food intolerance in patients where the patient is diagnosed with or suspected to have Ulcerative Colitis. Most preferably, such test kit or panel will include a plurality of distinct food preparations (e.g., raw or processed extract, preferably aqueous extract with optional co-solvent, which may or may not be filtered) that are coupled to individually addressable respective solid carriers (e.g., in a form of an array or a micro well plate), wherein the distinct food preparations have an average discriminatory p-value of ≤0.07 as determined by raw p-value or an average discriminatory p-value of ≤0.10 as determined by FDR multiplicity adjusted p-value. 
     In some embodiments, the numbers expressing quantities of ingredients, properties such as concentration, reaction conditions, and so forth, used to describe and claim certain embodiments of the invention are to be understood as being modified in some instances by the term “about.” Accordingly, in some embodiments, the numerical parameters set forth in the written description and attached claims are approximations that can vary depending upon the desired properties sought to be obtained by a particular embodiment. In some embodiments, the numerical parameters should be construed in light of the number of reported significant digits and by applying ordinary rounding techniques. Notwithstanding that the numerical ranges and parameters setting forth the broad scope of some embodiments of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as practicable. The numerical values presented in some embodiments of the invention may contain certain errors necessarily resulting from the standard deviation found in their respective testing measurements. Moreover, and unless the context dictates the contrary, all ranges set forth herein should be interpreted as being inclusive of their endpoints and open-ended ranges should be interpreted to include only commercially practical values. Similarly, all lists of values should be considered as inclusive of intermediate values unless the context indicates the contrary. 
     While not limiting to the inventive subject matter, food preparations will typically be drawn from foods generally known or suspected to trigger signs or symptoms of Ulcerative Colitis. Particularly suitable food preparations may be identified by the experimental procedures outlined below. Thus, it should be appreciated that the food items need not be limited to the items described herein, but that all items are contemplated that can be identified by the methods presented herein. Therefore, exemplary food preparations include at least two, at least four, at least eight, or at least 12 food preparations prepared from foods 1-58 of Table 2. Still further especially contemplated food items and food additives from which food preparations can be prepared are listed in Table 1. 
     Using bodily fluids from patients diagnosed with or suspected to have Ulcerative Colitis and healthy control group individuals (i.e., those not diagnosed with or not suspected to have Ulcerative Colitis), numerous additional food items may be identified. Preferably, such identified food items will have high discriminatory power and as such have a p-value of ≤0.15, more preferably ≤0.10, and most preferably ≤0.05 as determined by raw p-value, and/or a p-value of ≤0.10, more preferably ≤0.08, and most preferably ≤0.07 as determined by False Discovery Rate (FDR) multiplicity adjusted p-value. 
     In certain embodiments, such identified food preparations will have high discriminatory power and, as such, will have a p-value of ≤0.15, ≤0.10, or even ≤0.05 as determined by raw p-value, and/or a p-value of ≤0.10, ≤0.08, or even ≤0.07 as determined by False Discovery Rate (FDR) multiplicity adjusted p-value. 
     Therefore, where a panel has multiple food preparations, it is contemplated that the plurality of distinct food preparations has an average discriminatory p-value of ≤0.05 as determined by raw p-value or an average discriminatory p-value of ≤0.08 as determined by FDR multiplicity adjusted p-value, or even more preferably an average discriminatory p-value of ≤0.025 as determined by raw p-value or an average discriminatory p-value of ≤0.07 as determined by FDR multiplicity adjusted p-value. In further preferred aspects, it should be appreciated that the FDR multiplicity adjusted p-value may be adjusted for at least one of age and gender, and most preferably adjusted for both age and gender. On the other hand, where a test kit or panel is stratified for use with a single gender, it is also contemplated that in a test kit or panel at least 50% (and more typically 70% or all) of the plurality of distinct food preparations, when adjusted for a single gender, have an average discriminatory p-value of ≤0.07 as determined by raw p-value or an average discriminatory p-value of ≤0.10 as determined by FDR multiplicity adjusted p-value. Furthermore, it should be appreciated that other stratifications (e.g., dietary preference, ethnicity, place of residence, genetic predisposition or family history, etc.) are also contemplated, and the person of ordinary skill in the art (PHOSITA) will be readily appraised of the appropriate choice of stratification. 
     The recitation of ranges of values herein is merely intended to serve as a shorthand method of referring individually to each separate value falling within the range. Unless otherwise indicated herein, each individual value is incorporated into the specification as if it were individually recited herein. All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g., “such as”) provided with respect to certain embodiments herein is intended merely to better illuminate the invention and does not pose a limitation on the scope of the invention otherwise claimed. No language in the specification should be construed as indicating any non-claimed element essential to the practice of the invention. 
     Of course, it should be noted that the particular format of the test kit or panel may vary considerably and contemplated formats include micro well plates, dip sticks, membrane-bound arrays, etc. Consequently, the solid carrier to which the food preparations are coupled may include wells of a multiwell plate, a bead (e.g., color-coded or magnetic), or an adsorptive film (e.g., nitrocellulose or micro/nanoporous polymeric film), or an electrical sensor (e.g., a printed copper sensor or microchip). 
     Consequently, the inventors also contemplate a method of testing food intolerance in patients that are diagnosed with or suspected to have Ulcerative Colitis. Most typically, such methods will include a step of contacting a food preparation with a bodily fluid (e.g., whole blood, plasma, serum, saliva, or a fecal suspension) of a patient that is diagnosed with or suspected to have Ulcerative Colitis, and wherein the bodily fluid is associated with a gender identification. As noted before, the step of contacting is preferably performed under conditions that allow IgG (or IgE or IgA or IgM) from the bodily fluid to bind to at least one component of the food preparation, and the IgG bound to the component(s) of the food preparation are then quantified/measured to obtain a signal. In some embodiments, the signal is then compared against a gender-stratified reference value (e.g., at least a 90th percentile value) for the food preparation using the gender identification to obtain a result, which is then used to update or generate a report (e.g., written medical report; oral report of results from doctor to patient; written or oral directive from physician based on results). 
     In certain embodiments, such methods will not be limited to a single food preparation, but will employ multiple different food preparations. As noted before, suitable food preparations can be identified using various methods as described below, however, especially preferred food preparations include foods 1-58 of Table 2, and/or items of Table 1. As also noted above, it is generally preferred that at least some, or all of the different food preparations have an average discriminatory p-value of ≤0.07 (or ≤0.05, or ≤0.025) as determined by raw p-value, and/or or an average discriminatory p-value of ≤0.10 (or ≤0.08, or ≤0.07) as determined by FDR multiplicity adjusted p-value. 
     While in certain embodiments food preparations are prepared from single food items as crude extracts, or crude filtered extracts, it is contemplated that food preparations can be prepared from mixtures of a plurality of food items (e.g., a mixture of citrus comprising lemon, orange, and a grapefruit, a mixture of yeast comprising baker&#39;s yeast and brewer&#39;s yeast, a mixture of rice comprising a brown rice and white rice, a mixture of sugars comprising honey, malt, and cane sugar. In some embodiments, it is also contemplated that food preparations can be prepared from purified food antigens or recombinant food antigens. 
     As it is generally preferred that the food preparation is immobilized on a solid surface (typically in an addressable manner), it is contemplated that the step of measuring the IgG or other type of antibody bound to the component of the food preparation is performed via an ELISA test. Exemplary solid surfaces include, but are not limited to, wells in a multiwell plate, such that each food preparation may be isolated to a separate microwell. In certain embodiments, the food preparation will be coupled to, or immobilized on, the solid surface. In other embodiments, the food preparation(s) will be coupled to a molecular tag that allows for binding to human immunoglobulins (e.g., IgG) in solution. 
     Viewed from a different perspective, the inventors also contemplate a method of generating a test for food intolerance in patients diagnosed with or suspected to have Ulcerative Colitis. Because the test is applied to patients already diagnosed with or suspected to have Ulcerative Colitis, the authors do not contemplate that the method has a diagnostic purpose. Instead, the method is for identifying triggering food items among already diagnosed or suspected Ulcerative Colitis patients. Such test will typically include a step of obtaining one or more test results (e.g., ELISA) for various distinct food preparations, wherein the test results are based on bodily fluids (e.g., blood saliva, fecal suspension) of patients diagnosed with or suspected to have Ulcerative Colitis and bodily fluids of a control group not diagnosed with or not suspected to have Ulcerative Colitis. Most preferably, the test results are then stratified by gender for each of the distinct food preparations, a different cutoff value for male and female patients for each of the distinct food preparations (e.g., cutoff value for male and female patients has a difference of at least 10% (abs)) is assigned for a predetermined percentile rank (e.g., 90th or 95th percentile). 
     As noted earlier, and while not limiting to the inventive subject matter, it is contemplated that the distinct food preparations include at least two (or six, or ten, or 15) food preparations prepared from food items selected from the group consisting of foods 1-58 of Table 2, and/or items of Table 1. On the other hand, where new food items are tested, it should be appreciated that the distinct food preparations include a food preparation prepared from a food items other than foods 1-58 of Table 2. Regardless of the particular choice of food items, it is generally preferred however, that the distinct food preparations have an average discriminatory p-value of ≤0.07 (or ≤0.05, or ≤0.025) as determined by raw p-value or an average discriminatory p-value of ≤0.10 (or ≤0.08, or ≤0.07) as determined by FDR multiplicity adjusted p-value. Exemplary aspects and protocols, and considerations are provided in the experimental description below. 
     Thus, it should be appreciated that by having a high-confidence test system as described herein, the rate of false-positive and false negatives can be significantly reduced, and especially where the test systems and methods are gender stratified or adjusted for gender differences as shown below. Such advantages have heretofore not been realized and it is expected that the systems and methods presented herein will substantially increase the predictive power of food sensitivity tests for patients diagnosed with or suspected to have Ulcerative Colitis. 
     Experiments 
     General Protocol for food preparation generation: Commercially available food extracts (available from Biomerica Inc., 17571 Von Karman Ave, Irvine, Calif. 92614) prepared from the edible portion of the respective raw foods were used to prepare ELISA plates following the manufacturer&#39;s instructions. 
     For some food extracts, the inventors expect that food extracts prepared with specific procedures to generate food extracts provides more superior results in detecting elevated IgG reactivity in Ulcerative Colitis patients compared to commercially available food extracts. For example, for grains and nuts, a three-step procedure of generating food extracts is preferred. The first step is a defatting step. In this step, lipids from grains and nuts are extracted by contacting the flour of grains and nuts with a non-polar solvent and collecting residue. Then, the defatted grain or nut flour are extracted by contacting the flour with elevated pH to obtain a mixture and removing the solid from the mixture to obtain the liquid extract. Once the liquid extract is generated, the liquid extract is stabilized by adding an aqueous formulation. In a preferred embodiment, the aqueous formulation includes a sugar alcohol, a metal chelating agent, protease inhibitor, mineral salt, and buffer component 20-50 mM of buffer from 4-9 pH. This formulation allowed for long term storage at −70° C. and multiple freeze-thaws without a loss of activity. 
     For another example, for meats and fish, a two step procedure of generating food extract is preferred. The first step is an extraction step. In this step, extracts from raw, uncooked meats or fish are generated by emulsifying the raw, uncooked meats or fish in an aqueous buffer formulation in a high impact pressure processor. Then, solid materials are removed to obtain liquid extract. Once the liquid extract is generated, the liquid extract is stabilized by adding an aqueous formulation. In a preferred embodiment, the aqueous formulation includes a sugar alcohol, a metal chelating agent, protease inhibitor, mineral salt, and buffer component 20-50 mM of buffer from 4-9 pH. This formulation allowed for long term storage at −70° C. and multiple freeze-thaws without a loss of activity. 
     For still another example, for fruits and vegetables, a two step procedure of generating food extract is preferred. The first step is an extraction step. In this step, liquid extracts from fruits or vegetables are generated using an extractor (e.g., masticating juicer, etc) to pulverize foods and extract juice. Then, solid materials are removed to obtain liquid extract. Once the liquid extract is generated, the liquid extract is stabilized by adding an aqueous formulation. In a preferred embodiment, the aqueous formulation includes a sugar alcohol, a metal chelating agent, protease inhibitor, mineral salt, and buffer component 20-50 mM of buffer from 4-9 pH. This formulation allowed for long term storage at −70° C. and multiple freeze-thaws without a loss of activity. 
     Blocking of ELISA plates: To optimize signal to noise, plates will be blocked with a proprietary blocking buffer. In a preferred embodiment, the blocking buffer includes 20-50 mM of buffer from 4-9 pH, a protein of animal origin and a short chain alcohol. Other blocking buffers, including several commercial preparations, can be attempted but may not provide adequate signal to noise and low assay variability required. 
     ELISA preparation and sample testing: Food antigen preparations were immobilized onto respective microtiter wells following the manufacturer&#39;s instructions. For the assays, the food antigens were allowed to react with antibodies present in the patients&#39; serum, and excess serum proteins were removed by a wash step. For detection of IgG antibody binding, enzyme labeled anti-IgG antibody conjugate was allowed to react with antigen-antibody complex. A color was developed by the addition of a substrate that reacts with the coupled enzyme. The color intensity was measured and is directly proportional to the concentration of IgG antibody specific to a particular food antigen. 
     Methodology to determine ranked food list in order of ability of ELISA signals to distinguish Ulcerative Colitis from control subjects: Out of an initial selection (e.g., 100 food items, or 150 food items, or even more), samples can be eliminated prior to analysis due to low consumption in an intended population. In addition, specific food items can be used as being representative of a larger generic food group, especially where prior testing has established a correlation among different species within a generic group (most preferably in both genders, but also suitable for correlation for a single gender). For example, green pepper could be dropped in favor of chili pepper as representative of the “pepper” food group, or sweet potato could be dropped in favor of potato as representative of the “potato” food group. In further preferred aspects, the final list foods will be shorter than 50 food items, and more preferably equal or less than of 40 food items. 
     Since the foods ultimately selected for the food intolerance panel will not be specific for a particular gender, a gender-neutral food list is necessary. Since the observed sample will be at least initially imbalanced by gender (e.g., Controls: 40% female, Ulcerative Colitis: 55% female), differences in ELISA signal magnitude strictly due to gender will be removed by modeling signal scores against gender using a two-sample t-test and storing the residuals for further analysis. For each of the tested foods, residual signal scores will be compared between Ulcerative Colitis and controls using a permutation test on a two-sample t-test with a relative high number of resamplings (e.g., &gt;1,000, more preferably &gt;10,000, even more preferably &gt;50,000). The Satterthwaite approximation can then be used for the denominator degrees of freedom to account for lack of homogeneity of variances, and the 2-tailed permuted p-value will represent the raw p-value for each food. False Discovery Rates (FDR) among the comparisons, will be adjusted by any acceptable statistical procedures (e.g., Benjamin-Hochberg, Family-wise Error Rate (FWER), Per Comparison Error Rate (PCER), etc.). 
     Foods were then ranked according to their 2-tailed FDR multiplicity-adjusted p-values. Foods with adjusted p-values equal to or lower than the desired FDR threshold are deemed to have significantly higher signal scores among Ulcerative Colitis than control subjects and therefore deemed candidates for inclusion into a food intolerance panel. A typical result that is representative of the outcome of the statistical procedure is provided in Table 2. Here the ranking of foods is according to 2-tailed permutation T-test p-values with FDR adjustment. 
     Based on earlier experiments (data not shown here, see U.S. 62/327932), the inventors contemplate that even for the same food preparation tested, the ELISA score for at least several food items will vary dramatically, and exemplary raw data are provided in Table 3. As should be readily appreciated, data unstratified by gender will therefore lose significant explanatory power where the same cutoff value is applied to raw data for male and female data. To overcome such disadvantage, the inventors therefore contemplate stratification of the data by gender as described below. 
     Statistical Method for Cutpoint Selection for each Food: The determination of what 
     ELISA signal scores would constitute a “positive” response can be made by summarizing the distribution of signal scores among the Control subjects. For each food, Ulcerative Colitis subjects who have observed scores greater than or equal to selected quantiles of the Control subject distribution will be deemed “positive”. To attenuate the influence of any one subject on cutpoint determination, each food-specific and gender-specific dataset will be bootstrap resampled 1000 times. Within each bootstrap replicate, the 90th and 95th percentiles of the Control signal scores will be determined. Each Ulcerative Colitis subject in the bootstrap sample will be compared to the 90th and 95% percentiles to determine whether he/she had a “positive” response. The final 90th and 95th percentile-based cutpoints for each food and gender will be computed as the average 90th and 95th percentiles across the 1000 samples. The number of foods for which each Ulcerative Colitis subject will be rated as “positive” was computed by pooling data across foods. Using such method, the inventors will be now able to identify cutoff values for a predetermined percentile rank that in most cases was substantially different as can be taken from Table 4. 
     Typical examples for the gender difference in IgG response in blood with respect to green pea is shown in  FIGS. 1A-1D , where  FIG. 1A  shows the signal distribution in men along with the 95 th  percentile cutoff as determined from the male control population.  FIG. 1B  shows the distribution of percentage of male Ulcerative Colitis subjects exceeding the 90 th  and 95 th  percentile, while  FIG. 1C  shows the signal distribution in women along with the 95 th  percentile cutoff as determined from the female control population.  FIG. 1D  shows the distribution of percentage of female Ulcerative Colitis subjects exceeding the 90 th  and 95 th  percentile. In the same fashion,  FIGS. 2A-2D  exemplarily depict the differential response to cantaloupe,  FIGS. 3A-3D  exemplarily depict the differential response to pinto bean, and  FIGS. 4A-4D  exemplarily depict the differential response to cucumber.  FIGS. 5A-5B  show the distribution of Ulcerative Colitis subjects by number of foods that were identified as trigger foods at the 90 th  percentile ( 5 A) and 95 th  percentile ( 5 B). Inventors contemplate that regardless of the particular food items, male and female responses will be notably distinct. 
     It should be noted that nothing in the art have provided any predictable food groups related to Ulcerative Colitis that is gender-stratified. Thus, a discovery of food items that show distinct responses by gender is a surprising result, which could not be obviously expected in view of all previously available arts. In other words, selection of food items based on gender stratification provides an unexpected technical effect such that statistical significances for particular food items as triggering food among male or female Ulcerative Colitis patients have been significantly improved. 
     Normalization of IgG Response Data: While the raw data of the patient&#39;s IgG response results can be used to compare strength of response among given foods, it is also contemplated that the IgG response results of a patient are normalized and indexed to generate unit-less numbers for comparison of relative strength of response to a given food. For example, one or more of a patient&#39;s food specific IgG results (e.g., IgG specific to orange and IgG specific to malt) can be normalized to the patient&#39;s total IgG. The normalized value of the patient&#39;s IgG specific to orange can be 0.1 and the normalized value of the patient&#39;s IgG specific to malt can be 0.3. In this scenario, the relative strength of the patient&#39;s response to malt is three times higher compared to orange. Then, the patient&#39;s sensitivity to malt and orange can be indexed as such. 
     In other examples, one or more of a patient&#39;s food specific IgG results (e.g., IgG specific to shrimp and IgG specific to pork) can be normalized to the global mean of that patient&#39;s food specific IgG results. The global means of the patient&#39;s food specific IgG can be measured by total amount of the patient&#39;s food specific IgG. In this scenario, the patient&#39;s specific IgG to shrimp can be normalized to the mean of patient&#39;s total food specific IgG (e.g., mean of IgG levels to shrimp, pork, Dungeness crab, chicken, peas, etc.). However, it is also contemplated that the global means of the patient&#39;s food specific IgG can be measured by the patient&#39;s IgG levels to a specific type of food via multiple tests. If the patient have been tested for his sensitivity to shrimp five times and to pork seven times previously, the patient&#39;s new IgG values to shrimp or to pork are normalized to the mean of five-times test results to shrimp or the mean of seven-times test results to pork. The normalized value of the patient&#39;s IgG specific to shrimp can be 6.0 and the normalized value of the patient&#39;s IgG specific to pork can be 1.0. In this scenario, the patient has six times higher sensitivity to shrimp at this time compared to his average sensitivity to shrimp, but substantially similar sensitivity to pork. Then, the patient&#39;s sensitivity to shrimp and pork can be indexed based on such comparison. 
     Methodology to determine the subset of Ulcerative Colitis patients with food sensitivities that underlie Ulcerative Colitis: While it is suspected that food sensitivities plays a substantial role in signs and symptoms of Ulcerative Colitis, some Ulcerative Colitis patients may not have food sensitivities that underlie Ulcerative Colitis. Those patients would not be benefit from dietary intervention to treat signs and symptoms of Ulcerative Colitis. To determine the subset of such patients, body fluid samples of Ulcerative Colitis patients and non-Ulcerative Colitis patients can be tested with ELISA test using test devices with up to 58 food samples. 
     Table 5A and Table 5B provide exemplary raw data. As should be readily appreciated, the data indicate number of positive results out of 58 sample foods based on 90 th  percentile value (Table 5A) or 95 th  percentile value (Table 5B). The first column is Ulcerative Colitis (n=103); second column is non-Ulcerative Colitis (n=163) by ICD-10 code. Average and median number of positive foods was computed for Ulcerative Colitis and non-Ulcerative Colitis patients. From the raw data shown in Table 5A and Table 5B, average and standard deviation of the number of positive foods was computed for Ulcerative Colitis and non-Ulcerative Colitis patients. Additionally, the number and percentage of patients with zero positive foods was calculated for both Ulcerative Colitis and non-Ulcerative Colitis. The number and percentage of patients with zero positive foods in the Ulcerative Colitis population is more than 6-fold lower than the percentage of patients with zero positive foods in the non-Ulcerative Colitis population (3% vs. 19%, respectively) based on 90 th  percentile value (Table 5A), and the percentage of patients in the Ulcerative Colitis population with zero positive foods is also less than half of that seen in the non-Ulcerative Colitis population (12% vs. 31%, respectively) based on 95 th  percentile value (Table 5B). Thus, it can be easily appreciated that the Ulcerative Colitis patient having sensitivity to zero positive foods is unlikely to have food sensitivities underlying their signs and symptoms of Ulcerative Colitis. 
     Table 6A and Table 7A show exemplary statistical data summarizing the raw data of two patient populations shown in Table 5A. The statistical data includes normality, arithmetic mean, median, percentiles and 95% confidence interval (CI) for the mean and median representing number of positive foods in the Ulcerative Colitis population and the non-Ulcerative Colitis population. Table 6B and Table 7B show exemplary statistical data summarizing the raw data of two patient populations shown in Table 5B. The statistical data includes normality, arithmetic mean, median, percentiles and 95% confidence interval (CI) for the mean and median representing number of positive foods in the Ulcerative Colitis population and the non-Ulcerative Colitis population. 
     Table 8A and Table 9A show exemplary statistical data summarizing the raw data of two patient populations shown in Table 5A. In Tables 8A and 9A, the raw data was transformed by logarithmic transformation to improve the data interpretation. Table 8B and Table 9B show another exemplary statistical data summarizing the raw data of two patient populations shown in Table 5B. In Tables 8B and 9B, the raw data was transformed by logarithmic transformation to improve the data interpretation. 
     Table 10A and Table 11A show exemplary statistical data of an independent T-test (Table 10A, logarithmically transformed data) and a Mann-Whitney test (Table 11A) to compare the geometric mean number of positive foods between the Ulcerative Colitis and non-Ulcerative Colitis samples. The data shown in Table 10A and Table 11A indicate statistically significant differences in the geometric mean of positive number of foods between the Ulcerative Colitis population and the non-Ulcerative Colitis population. In both statistical tests, it is shown that the number of positive responses with 58 food samples is significantly higher in the Ulcerative Colitis population than in the non-Ulcerative Colitis population with an average discriminatory p-value of ≤0.0001. These statistical data is also illustrated as a box and whisker plot in  FIG. 6A , and a notched box and whisker plot in  FIG. 6B . 
     Table 10B and Table 11B show exemplary statistical data of an independent T-test (Table 10A, logarithmically transformed data) and a Mann-Whitney test (Table 11B) to compare the geometric mean number of positive foods between the Ulcerative Colitis and non-Ulcerative Colitis samples. The data shown in Table 10B and Table 11B indicate statistically significant differences in the geometric mean of positive number of foods between the Ulcerative Colitis population and the non-Ulcerative Colitis population. In both statistical tests, it is shown that the number of positive responses with 58 food samples is significantly higher in the Ulcerative Colitis population than in the non-Ulcerative Colitis population with an average discriminatory p-value of ≤0.0001. These statistical data is also illustrated as a box and whisker plot in  FIG. 6C , and a notched box and whisker plot in  FIG. 6D . 
     Table 12A shows exemplary statistical data of a Receiver Operating Characteristic (ROC) curve analysis of data shown in Tables 5A-11A to determine the diagnostic power of the test used in Table 5 at discriminating Ulcerative Colitis from non-Ulcerative Colitis subjects. When a cutoff criterion of more than 5 positive foods is used, the test yields a data with 66% sensitivity and 68% specificity, with an area under the curve (AUROC) of 0.720. The p-value for the ROC is significant at a p-value of &lt;0.0001.  FIG. 7A  illustrates the ROC curve corresponding to the statistical data shown in Table 12A. Because the statistical difference between the Ulcerative Colitis population and the non-Ulcerative Colitis population is significant when the test results are cut off to a positive number of 5, the number of foods for which a patient tests positive could be used as a confirmation of the primary clinical diagnosis of Ulcerative Colitis, and whether it is likely that food sensitivities underlies on the patient&#39;s signs and symptoms of Ulcerative Colitis. Therefore, the above test can be used as another ‘rule in’ test to add to currently available clinical criteria for diagnosis for Ulcerative Colitis. 
     As shown in Tables 5A-12A, and  FIG. 7A , based on 90 th  percentile data, the number of positive foods seen in Ulcerative Colitis vs. non-Ulcerative Colitis subjects is significantly different whether the geometric mean or median of the data is compared. The number of positive foods that a person has is indicative of the presence of Ulcerative Colitis in subjects. The test has discriminatory power to detect Ulcerative Colitis with ˜66% sensitivity and ˜68% specificity. Additionally, the absolute number and percentage of subjects with 0 positive foods is also very different in Ulcerative Colitis vs. non-Ulcerative Colitis subjects, with a far lower percentage of Ulcerative Colitis subjects (3%) having 0 positive foods than non-Ulcerative Colitis subjects (19%). The data suggests a subset of Ulcerative Colitis patients may have Ulcerative Colitis due to other factors than diet, and may not benefit from dietary restriction. 
     Table 12B shows exemplary statistical data of a Receiver Operating Characteristic (ROC) curve analysis of data shown in Tables 5B-11B to determine the diagnostic power of the test used in Table 5 at discriminating Ulcerative Colitis from non-Ulcerative Colitis subjects. When a cutoff criterion of more than 3 positive foods is used, the test yields a data with 60.2% sensitivity and 75.5% specificity, with an area under the curve (AUROC) of 0.719. The p-value for the ROC is significant at a p-value of &lt;0.0001.  FIG. 7B  illustrates the ROC curve corresponding to the statistical data shown in Table 12B. Because the statistical difference between the Ulcerative Colitis population and the non-Ulcerative Colitis population is significant when the test results are cut off to positive number of &gt;3, the number of foods that a patient tests positive could be used as a confirmation of the primary clinical diagnosis of Ulcerative Colitis, and whether it is likely that food sensitivities underlies on the patient&#39;s signs and symptoms of Ulcerative Colitis. Therefore, the above test can be used as another ‘rule in’ test to add to currently available clinical criteria for diagnosis for Ulcerative Colitis. 
     As shown in Tables 5B-12B, and  FIG. 7B , based on 95 th  percentile data, the number of positive foods seen in Ulcerative Colitis vs. non-Ulcerative Colitis subjects is significantly different whether the geometric mean or median of the data is compared. The number of positive foods that a person has is indicative of the presence of Ulcerative Colitis in subjects. The test has discriminatory power to detect Ulcerative Colitis with ˜60% sensitivity and ˜76% specificity. Additionally, the absolute number and percentage of subjects with 0 positive foods is also very different in Ulcerative Colitis vs. non-Ulcerative Colitis subjects, with a far lower percentage of Ulcerative Colitis subjects (˜19%) having 0 positive foods than non-Ulcerative Colitis subjects (˜31%). The data suggests a subset of Ulcerative Colitis patients may have Ulcerative Colitis due to other factors than diet, and may not benefit from dietary restriction. 
     Method for determining distribution of per-person number of foods declared “positive”: To determine the distribution of number of “positive” foods per person and measure the diagnostic performance, the analysis will be performed with 58 food items from Table 2, which shows most positive responses to Ulcerative Colitis patients. To attenuate the influence of any one subject on this analysis, each food-specific and gender-specific dataset will be bootstrap resampled 1000 times. Then, for each food item in the bootstrap sample, sex-specific cutpoint will be determined using the 90th and 95th percentiles of the control population. Once the sex-specific cutpoints are determined, the sex-specific cutpoints will be compared with the observed ELISA signal scores for both control and Ulcerative Colitis subjects. In this comparison, if the observed signal is equal or more than the cutpoint value, then it will be determined “positive” food, and if the observed signal is less than the cutpoint value, then it will be determined “negative” food. 
     Once all food items were determined either positive or negative, the results of the 116 (58 foods×2 cutpoints) calls for each subject will be saved within each bootstrap replicate. Then, for each subject, 58 calls will be summed using 90 th  percentile as cutpoint to get “Number of Positive Foods (90 th ),” and the rest of 58 calls will be summed using 95 th  percentile to get “Number of Positive Foods (95 th ).” Then, within each replicate, “Number of Positive Foods (90 th )” and “Number of Positive Foods (95 th )” will be summarized across subjects to get descriptive statistics for each replicate as follows: 1) overall means equals to the mean of means, 2) overall standard deviation equals to the mean of standard deviations, 3) overall medial equals to the mean of medians, 4) overall minimum equals to the minimum of minimums, and 5) overall maximum equals to maximum of maximum. In this analysis, to avoid non-integer “Number of Positive Foods” when computing frequency distribution and histogram, the authors will pretend that the 1000 repetitions of the same original dataset were actually 999 sets of new subjects of the same size added to the original sample. Once the summarization of data is done, frequency distributions and histograms will be generated for both “Number of Positive Foods (90 th )” and “Number of Positive Foods (95 th )” for both genders and for both Ulcerative Colitis subjects and control subjects using programs “a_pos_foods.sas, a_pos_foods_by_dx.sas”. 
     Method for measuring diagnostic performance: To measure diagnostic performance for each food items for each subject, we will use data of “Number of Positive Foods (90 th )” and “Number of Positive Foods (95th)” for each subject within each bootstrap replicate described above. In this analysis, the cutpoint was set to 1. Thus, if a subject has one or more “Number of Positive Foods (90th)”, then the subject will be called “Has Ulcerative Colitis.” If a subject has less than one “Number of Positive Foods (90th)”, then the subject will be called “Does Not Have Ulcerative Colitis.” When all calls were made, the calls were compared with actual diagnosis to determine whether a call was a True Positive (TP), True Negative (TN), False Positive (FP), or False Negative (FN). The comparisons will be summarized across subjects to get the performance metrics of sensitivity, specificity, positive predictive value, and negative predictive value for both “Number of Positive Foods (90 th )” and “Number of Positive Foods(95 th )” when the cutpoint is set to 1 for each method. Each (sensitivity, 1-specificity) pair becomes a point on the ROC curve for this replicate. 
     To increase the accuracy, the analysis above will be repeated by incrementing cutpoint from 2 up to 58, and repeated for each of the 1000 bootstrap replicates. Then the performance metrics across the 1000 bootstrap replicates will be summarized by calculating averages using a program “t_pos_foods_by_dx.sas”. The results of diagnostic performance for female and male are shown in Tables 13A and 13B (90th percentile) and Tables 14A and 14B (95th percentile). 
     Of course, it should be appreciated that certain variations in the food preparations may be made without altering the inventive subject matter presented herein. For example, where the food item was yellow onion, that item should be understood to also include other onion varieties that were demonstrated to have equivalent activity in the tests. Indeed, the inventors have noted that for each tested food preparation, certain other related food preparations also tested in the same or equivalent manner (data not shown). Thus, it should be appreciated that each tested and claimed food preparation will have equivalent related preparations with demonstrated equal or equivalent reactions in the test. 
     It should be apparent to those skilled in the art that many more modifications besides those already described are possible without departing from the inventive concepts herein. The inventive subject matter, therefore, is not to be restricted except in the spirit of the appended claims. Moreover, in interpreting both the specification and the claims, all terms should be interpreted in the broadest possible manner consistent with the context. In particular, the terms “comprises” and “comprising” should be interpreted as referring to elements, components, or steps in a non-exclusive manner, indicating that the referenced elements, components, or steps may be present, or utilized, or combined with other elements, components, or steps that are not expressly referenced. Where the specification claims refers to at least one of something selected from the group consisting of A, B, C . . . and N, the text should be interpreted as requiring only one element from the group, not A plus N, or B plus N, etc. 
     
       
         
           
               
               
             
               
                   
                 TABLE 1 
               
               
                   
                   
               
             
            
               
                   
                 Abalone 
               
               
                   
                 Adlay 
               
               
                   
                 Almond 
               
               
                   
                 American Cheese 
               
               
                   
                 Apple 
               
               
                   
                 Artichoke 
               
               
                   
                 Asparagus 
               
               
                   
                 Avocado 
               
               
                   
                 Baby Bok Choy 
               
               
                   
                 Bamboo shoots 
               
               
                   
                 Banana 
               
               
                   
                 Barley, whole grain 
               
               
                   
                 Beef 
               
               
                   
                 Beets 
               
               
                   
                 Beta-lactoglobulin 
               
               
                   
                 Blueberry 
               
               
                   
                 Broccoli 
               
               
                   
                 Buckwheat 
               
               
                   
                 Butter 
               
               
                   
                 Cabbage 
               
               
                   
                 Cane sugar 
               
               
                   
                 Cantaloupe 
               
               
                   
                 Caraway 
               
               
                   
                 Carrot 
               
               
                   
                 Casein 
               
               
                   
                 Cashew 
               
               
                   
                 Cauliflower 
               
               
                   
                 Celery 
               
               
                   
                 Chard 
               
               
                   
                 Cheddar Cheese 
               
               
                   
                 Chick Peas 
               
               
                   
                 Chicken 
               
               
                   
                 Chili pepper 
               
               
                   
                 Chocolate 
               
               
                   
                 Cinnamon 
               
               
                   
                 Clam 
               
               
                   
                 Cocoa Bean 
               
               
                   
                 Coconut 
               
               
                   
                 Codfish 
               
               
                   
                 Coffee 
               
               
                   
                 Cola nut 
               
               
                   
                 Corn 
               
               
                   
                 Cottage cheese 
               
               
                   
                 Cow&#39;s milk 
               
               
                   
                 Crab 
               
               
                   
                 Cucumber 
               
               
                   
                 Cured Cheese 
               
               
                   
                 Cuttlefish 
               
               
                   
                 Duck 
               
               
                   
                 Durian 
               
               
                   
                 Eel 
               
               
                   
                 Egg White (separate) 
               
               
                   
                 Egg Yolk (separate) 
               
               
                   
                 Egg, white/yolk (comb.) 
               
               
                   
                 Eggplant 
               
               
                   
                 Garlic 
               
               
                   
                 Ginger 
               
               
                   
                 Gluten-Gliadin 
               
               
                   
                 Goat&#39;s milk 
               
               
                   
                 Grape, white/concord 
               
               
                   
                 Grapefruit 
               
               
                   
                 Grass Carp 
               
               
                   
                 Green Onion 
               
               
                   
                 Green pea 
               
               
                   
                 Green pepper 
               
               
                   
                 Guava 
               
               
                   
                 Hair Tail 
               
               
                   
                 Hake 
               
               
                   
                 Halibut 
               
               
                   
                 Hazelnut 
               
               
                   
                 Honey 
               
               
                   
                 Kelp 
               
               
                   
                 Kidney bean 
               
               
                   
                 Kiwi Fruit 
               
               
                   
                 Lamb 
               
               
                   
                 Leek 
               
               
                   
                 Lemon 
               
               
                   
                 Lentils 
               
               
                   
                 Lettuce, Iceberg 
               
               
                   
                 Lima bean 
               
               
                   
                 Lobster 
               
               
                   
                 Longan 
               
               
                   
                 Mackerel 
               
               
                   
                 Malt 
               
               
                   
                 Mango 
               
               
                   
                 Marjoram 
               
               
                   
                 Millet 
               
               
                   
                 Mung bean 
               
               
                   
                 Mushroom 
               
               
                   
                 Mustard seed 
               
               
                   
                 Oat 
               
               
                   
                 Olive 
               
               
                   
                 Onion 
               
               
                   
                 Orange 
               
               
                   
                 Oyster 
               
               
                   
                 Papaya 
               
               
                   
                 Paprika 
               
               
                   
                 Parsley 
               
               
                   
                 Peach 
               
               
                   
                 Peanut 
               
               
                   
                 Pear 
               
               
                   
                 Pepper, Black 
               
               
                   
                 Pineapple 
               
               
                   
                 Pinto bean 
               
               
                   
                 Plum 
               
               
                   
                 Pork 
               
               
                   
                 Potato 
               
               
                   
                 Rabbit 
               
               
                   
                 Rice 
               
               
                   
                 Roquefort Cheese 
               
               
                   
                 Rye 
               
               
                   
                 Saccharine 
               
               
                   
                 Safflower seed 
               
               
                   
                 Salmon 
               
               
                   
                 Sardine 
               
               
                   
                 Scallop 
               
               
                   
                 Sesame 
               
               
                   
                 Shark fin 
               
               
                   
                 Sheep&#39;s milk 
               
               
                   
                 Shrimp 
               
               
                   
                 Sole 
               
               
                   
                 Soybean 
               
               
                   
                 Spinach 
               
               
                   
                 Squashes 
               
               
                   
                 Squid 
               
               
                   
                 Strawberry 
               
               
                   
                 String bean 
               
               
                   
                 Sunflower seed 
               
               
                   
                 Sweet potato 
               
               
                   
                 Swiss cheese 
               
               
                   
                 Taro 
               
               
                   
                 Tea, black 
               
               
                   
                 Tobacco 
               
               
                   
                 Tomato 
               
               
                   
                 Trout 
               
               
                   
                 Tuna 
               
               
                   
                 Turkey 
               
               
                   
                 Vanilla 
               
               
                   
                 Walnut, black 
               
               
                   
                 Watermelon 
               
               
                   
                 Welch Onion 
               
               
                   
                 Wheat 
               
               
                   
                 Wheat bran 
               
               
                   
                 Yeast ( S. cerevisiae ) 
               
               
                   
                 Yogurt 
               
               
                   
                 FOOD ADDITIVES 
               
               
                   
                 Arabic Gum 
               
               
                   
                 Carboxymethyl Cellulose 
               
               
                   
                 Carrageneenan 
               
               
                   
                 FD&amp;C Blue #1 
               
               
                   
                 FD&amp;C Red #3 
               
               
                   
                 FD&amp;C Red #40 
               
               
                   
                 FD&amp;C Yellow #5 
               
               
                   
                 FD&amp;C Yellow #6 
               
               
                   
                 Gelatin 
               
               
                   
                 Guar Gum 
               
               
                   
                 Maltodextrin 
               
               
                   
                 Pectin 
               
               
                   
                 Whey 
               
               
                   
                 Xanthan Gum 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 Ranking of Foods according to 2-tailed Permutation T-test 
               
               
                 p-values with FDR adjustment 
               
            
           
           
               
               
               
               
            
               
                   
                   
                   
                 FDR 
               
               
                   
                   
                 Raw 
                 Multiplicity-adj 
               
               
                 Rank 
                 Food 
                 p-value 
                 p-value 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 1 
                 Green_Pea 
                 0.0000 
                 0.0000 
               
               
                 2 
                 Cantaloupe 
                 0.0000 
                 0.0009 
               
               
                 3 
                 Pinto_Bean 
                 0.0001 
                 0.0021 
               
               
                 4 
                 Cucumber 
                 0.0001 
                 0.0021 
               
               
                 5 
                 Green_Pepper 
                 0.0001 
                 0.0021 
               
               
                 6 
                 Grapefruit 
                 0.0002 
                 0.0021 
               
               
                 7 
                 Carrot 
                 0.0002 
                 0.0021 
               
               
                 8 
                 Orange 
                 0.0002 
                 0.0021 
               
               
                 9 
                 Almond 
                 0.0002 
                 0.0021 
               
               
                 10 
                 Sardine 
                 0.0003 
                 0.0021 
               
               
                 11 
                 Sweet_Pot —   
                 0.0003 
                 0.0021 
               
               
                 12 
                 Broccoli 
                 0.0003 
                 0.0021 
               
               
                 13 
                 Garlic 
                 0.0003 
                 0.0021 
               
               
                 14 
                 Lima_Bean 
                 0.0003 
                 0.0021 
               
               
                 15 
                 Squashes 
                 0.0004 
                 0.0024 
               
               
                 16 
                 Celery 
                 0.0004 
                 0.0025 
               
               
                 17 
                 String_Bean 
                 0.0006 
                 0.0030 
               
               
                 18 
                 Tomato 
                 0.0008 
                 0.0040 
               
               
                 19 
                 Cauliflower 
                 0.0009 
                 0.0041 
               
               
                 20 
                 Walnut_Blk 
                 0.0010 
                 0.0046 
               
               
                 21 
                 Sunflower_Sd 
                 0.0012 
                 0.0051 
               
               
                 22 
                 Cane_Sugar 
                 0.0012 
                 0.0051 
               
               
                 23 
                 Buck_Wheat 
                 0.0028 
                 0.0106 
               
               
                 24 
                 Soybean 
                 0.0028 
                 0.0106 
               
               
                 25 
                 Lemon 
                 0.0030 
                 0.0108 
               
               
                 26 
                 Barley 
                 0.0047 
                 0.0163 
               
               
                 27 
                 Oat 
                 0.0051 
                 0.0170 
               
               
                 28 
                 Oyster 
                 0.0055 
                 0.0173 
               
               
                 29 
                 Mustard 
                 0.0056 
                 0.0173 
               
               
                 30 
                 Rye 
                 0.0058 
                 0.0173 
               
               
                 31 
                 Peach 
                 0.0068 
                 0.0196 
               
               
                 32 
                 Chili_Pepper 
                 0.0072 
                 0.0201 
               
               
                 33 
                 Spinach 
                 0.0082 
                 0.0222 
               
               
                 34 
                 Peanut 
                 0.0084 
                 0.0222 
               
               
                 35 
                 Avocado 
                 0.0088 
                 0.0226 
               
               
                 36 
                 Shrimp 
                 0.0094 
                 0.0236 
               
               
                 37 
                 Pineapple 
                 0.0098 
                 0.0239 
               
               
                 38 
                 Cola_Nut 
                 0.0118 
                 0.0275 
               
               
                 39 
                 Rice 
                 0.0119 
                 0.0275 
               
               
                 40 
                 Cabbage 
                 0.0131 
                 0.0294 
               
               
                 41 
                 Butter 
                 0.0150 
                 0.0330 
               
               
                 42 
                 Eggplant 
                 0.0156 
                 0.0330 
               
               
                 43 
                 Apple 
                 0.0158 
                 0.0330 
               
               
                 44 
                 Egg 
                 0.0176 
                 0.0359 
               
               
                 45 
                 Wheat 
                 0.0215 
                 0.0419 
               
               
                 46 
                 Cottage_Ch —   
                 0.0219 
                 0.0419 
               
               
                 47 
                 Sole 
                 0.0219 
                 0.0419 
               
               
                 48 
                 Cashew 
                 0.0238 
                 0.0446 
               
               
                 49 
                 Olive 
                 0.0259 
                 0.0476 
               
               
                 50 
                 Parsley 
                 0.0276 
                 0.0496 
               
               
                 51 
                 Corn 
                 0.0340 
                 0.0578 
               
               
                 52 
                 Honey 
                 0.0340 
                 0.0578 
               
               
                 53 
                 Chocolate 
                 0.0345 
                 0.0578 
               
               
                 54 
                 Cow_Milk 
                 0.0347 
                 0.0578 
               
               
                 55 
                 Potato 
                 0.0359 
                 0.0587 
               
               
                 56 
                 Onion 
                 0.0467 
                 0.0750 
               
               
                 57 
                 Tea 
                 0.0506 
                 0.0799 
               
               
                 58 
                 Tobacco 
                 0.0625 
                 0.0970 
               
               
                 59 
                 Banana 
                 0.0706 
                 0.1078 
               
               
                 60 
                 Strawberry 
                 0.0751 
                 0.1127 
               
               
                 61 
                 Coffee 
                 0.0771 
                 0.1138 
               
               
                 62 
                 Malt 
                 0.0823 
                 0.1195 
               
               
                 63 
                 Scallop 
                 0.0887 
                 0.1268 
               
               
                 64 
                 Chicken 
                 0.0987 
                 0.1388 
               
               
                 65 
                 Yeast_Baker 
                 0.1152 
                 0.1595 
               
               
                 66 
                 Millet 
                 0.1171 
                 0.1597 
               
               
                 67 
                 Swiss_Ch —   
                 0.1770 
                 0.2378 
               
               
                 68 
                 Turkey 
                 0.1806 
                 0.2381 
               
               
                 69 
                 Cheddar_Ch —   
                 0.1826 
                 0.2381 
               
               
                 70 
                 Yeast_Brewer 
                 0.2178 
                 0.2801 
               
               
                 71 
                 Yogurt 
                 0.2255 
                 0.2859 
               
               
                 72 
                 Cinnamon 
                 0.2600 
                 0.3250 
               
               
                 73 
                 Clam 
                 0.2998 
                 0.3696 
               
               
                 74 
                 Tuna 
                 0.3102 
                 0.3762 
               
               
                 75 
                 Beef 
                 0.3135 
                 0.3762 
               
               
                 76 
                 Lettuce 
                 0.3266 
                 0.3868 
               
               
                 77 
                 Trout 
                 0.3672 
                 0.4292 
               
               
                 78 
                 Safflower 
                 0.4487 
                 0.5178 
               
               
                 79 
                 Codfish 
                 0.4712 
                 0.5368 
               
               
                 80 
                 Salmon 
                 0.5076 
                 0.5711 
               
               
                 81 
                 Mushroom 
                 0.5634 
                 0.6260 
               
               
                 82 
                 Grape 
                 0.5825 
                 0.6389 
               
               
                 83 
                 Blueberry 
                 0.5892 
                 0.6389 
               
               
                 84 
                 Pork 
                 0.7160 
                 0.7667 
               
               
                 85 
                 Sesame 
                 0.7241 
                 0.7667 
               
               
                 86 
                 Amer_Cheese 
                 0.7739 
                 0.8099 
               
               
                 87 
                 Lobster 
                 0.7946 
                 0.8220 
               
               
                 88 
                 Halibut 
                 0.8497 
                 0.8690 
               
               
                 89 
                 Goat_Milk 
                 0.9112 
                 0.9215 
               
               
                 90 
                 Crab 
                 0.9888 
                 0.9888 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 Basic Descriptive Statistics of ELISA Score by Food 
               
               
                 and Gender Comparing Ulcerative Colitis to Control 
               
            
           
           
               
               
            
               
                   
                 ELISA Score 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 Sex 
                 Food 
                 Diagnosis 
                 N 
                 Mean 
                 SD 
                 Min 
                 Max 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 FEMALE 
                 Almond 
                 Ulcerative_Colitis 
                 57 
                 10.079 
                 25.036 
                 0.439 
                 158.47  
               
               
                   
                   
                 Control 
                 66 
                 4.034 
                 2.187 
                 0.100 
                 13.068 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 6.045 
                 17.107 
                 — 
                 — 
               
               
                   
                 Amer_Cheese 
                 Ulcerative_Colitis 
                 57 
                 21.630 
                 31.036 
                 1.602 
                 140.07  
               
               
                   
                   
                 Control 
                 66 
                 23.434 
                 52.616 
                 0.100 
                 400.00  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −1.804 
                 43.965 
                 — 
                 — 
               
               
                   
                 Apple 
                 Ulcerative_Colitis 
                 57 
                 5.340 
                 4.304 
                 0.493 
                 28.693 
               
               
                   
                   
                 Control 
                 66 
                 4.432 
                 3.291 
                 0.100 
                 15.890 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 0.908 
                 3.793 
                 — 
                 — 
               
               
                   
                 Avocado 
                 Ulcerative_Colitis 
                 57 
                 3.858 
                 3.507 
                 0.100 
                 21.077 
               
               
                   
                   
                 Control 
                 66 
                 2.930 
                 2.339 
                 0.100 
                 14.256 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 0.927 
                 2.938 
                 — 
                 — 
               
               
                   
                 Banana 
                 Ulcerative_Colitis 
                 57 
                 19.827 
                 46.868 
                 0.100 
                 256.94  
               
               
                   
                   
                 Control 
                 66 
                 8.063 
                 14.962 
                 0.100 
                 83.654 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 11.765 
                 33.717 
                 — 
                 — 
               
               
                   
                 Barley 
                 Ulcerative_Colitis 
                 57 
                 25.942 
                 30.538 
                 1.974 
                 165.95  
               
               
                   
                   
                 Control 
                 66 
                 19.090 
                 12.984 
                 3.026 
                 64.831 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 6.851 
                 22.851 
                 — 
                 — 
               
               
                   
                 Beef 
                 Ulcerative_Colitis 
                 57 
                 11.027 
                 14.479 
                 1.479 
                 83.266 
               
               
                   
                   
                 Control 
                 66 
                 10.288 
                 13.960 
                 3.026 
                 104.76  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 0.739 
                 14.202 
                 — 
                 — 
               
               
                   
                 Blueberry 
                 Ulcerative_Colitis 
                 57 
                 5.142 
                 3.166 
                 1.206 
                 17.780 
               
               
                   
                   
                 Control 
                 66 
                 5.440 
                 3.773 
                 0.100 
                 26.772 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −0.298 
                 3.505 
                 — 
                 — 
               
               
                   
                 Broccoli 
                 Ulcerative_Colitis 
                 57 
                 11.435 
                 15.944 
                 1.355 
                 99.132 
               
               
                   
                   
                 Control 
                 66 
                 6.280 
                 5.292 
                 0.100 
                 36.378 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 5.154 
                 11.520 
                 — 
                 — 
               
               
                   
                 Buck_Wheat 
                 Ulcerative_Colitis 
                 57 
                 12.377 
                 18.040 
                 1.848 
                 104.34  
               
               
                   
                   
                 Control 
                 66 
                 8.034 
                 4.990 
                 1.316 
                 29.397 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 4.342 
                 12.806 
                 — 
                 — 
               
               
                   
                 Butter 
                 Ulcerative_Colitis 
                 57 
                 25.891 
                 26.436 
                 3.865 
                 154.85  
               
               
                   
                   
                 Control 
                 66 
                 21.874 
                 29.162 
                 0.100 
                 204.33  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 4.017 
                 27.933 
                 — 
                 — 
               
               
                   
                 Cabbage 
                 Ulcerative_Colitis 
                 57 
                 13.302 
                 23.916 
                 0.123 
                 135.74  
               
               
                   
                   
                 Control 
                 66 
                 7.362 
                 10.123 
                 0.100 
                 56.932 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 5.940 
                 17.882 
                 — 
                 — 
               
               
                   
                 Cane_Sugar 
                 Ulcerative_Colitis 
                 57 
                 32.174 
                 30.535 
                 8.009 
                 178.78  
               
               
                   
                   
                 Control 
                 66 
                 18.288 
                 9.172 
                 2.632 
                 43.466 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 13.885 
                 21.833 
                 — 
                 — 
               
               
                   
                 Cantaloupe 
                 Ulcerative_Colitis 
                 57 
                 12.200 
                 20.373 
                 0.751 
                 149.18  
               
               
                   
                   
                 Control 
                 66 
                 6.154 
                 6.160 
                 0.100 
                 48.752 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 6.046 
                 14.576 
                 — 
                 — 
               
               
                   
                 Carrot 
                 Ulcerative_Colitis 
                 57 
                 6.467 
                 6.804 
                 0.987 
                 47.767 
               
               
                   
                   
                 Control 
                 66 
                 4.813 
                 3.705 
                 0.100 
                 24.141 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 1.654 
                 5.367 
                 — 
                 — 
               
               
                   
                 Cashew 
                 Ulcerative_Colitis 
                 57 
                 12.920 
                 21.204 
                 0.966 
                 98.745 
               
               
                   
                   
                 Control 
                 66 
                 9.924 
                 16.382 
                 0.100 
                 94.907 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 2.996 
                 18.768 
                 — 
                 — 
               
               
                   
                 Cauliflower 
                 Ulcerative_Colitis 
                 57 
                 9.756 
                 18.230 
                 0.100 
                 131.25  
               
               
                   
                   
                 Control 
                 66 
                 5.977 
                 8.336 
                 0.100 
                 58.808 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 3.778 
                 13.825 
                 — 
                 — 
               
               
                   
                 Celery 
                 Ulcerative_Colitis 
                 57 
                 12.601 
                 15.076 
                 3.080 
                 107.65  
               
               
                   
                   
                 Control 
                 66 
                 9.634 
                 5.975 
                 0.395 
                 32.141 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 2.967 
                 11.152 
                 — 
                 — 
               
               
                   
                 Cheddar_Ch —   
                 Ulcerative_Colitis 
                 57 
                 32.153 
                 50.450 
                 1.833 
                 266.75  
               
               
                   
                   
                 Control 
                 66 
                 26.852 
                 55.697 
                 0.100 
                 400.00  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 5.302 
                 53.333 
                 — 
                 — 
               
               
                   
                 Chicken 
                 Ulcerative_Colitis 
                 57 
                 21.024 
                 19.326 
                 3.865 
                 106.76  
               
               
                   
                   
                 Control 
                 66 
                 18.303 
                 10.514 
                 4.743 
                 61.887 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 2.721 
                 15.240 
                 — 
                 — 
               
               
                   
                 Chili_Pepper 
                 Ulcerative_Colitis 
                 57 
                 9.931 
                 9.801 
                 1.517 
                 56.432 
               
               
                   
                   
                 Control 
                 66 
                 8.577 
                 7.784 
                 0.100 
                 42.583 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 1.355 
                 8.775 
                 — 
                 — 
               
               
                   
                 Chocolate 
                 Ulcerative_Colitis 
                 57 
                 18.043 
                 15.319 
                 3.510 
                 71.901 
               
               
                   
                   
                 Control 
                 66 
                 14.350 
                 6.578 
                 3.006 
                 35.317 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 3.693 
                 11.483 
                 — 
                 — 
               
               
                   
                 Cinnamon 
                 Ulcerative_Colitis 
                 57 
                 34.013 
                 22.107 
                 5.090 
                 119.22  
               
               
                   
                   
                 Control 
                 66 
                 32.170 
                 24.180 
                 5.374 
                 132.49  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 1.843 
                 23.244 
                 — 
                 — 
               
               
                   
                 Clam 
                 Ulcerative_Colitis 
                 57 
                 39.841 
                 37.147 
                 9.968 
                 197.01  
               
               
                   
                   
                 Control 
                 66 
                 52.166 
                 58.253 
                 7.819 
                 400.00  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −12.324 
                 49.614 
                 — 
                 — 
               
               
                   
                 Codfish 
                 Ulcerative_Colitis 
                 57 
                 17.321 
                 10.395 
                 3.450 
                 50.000 
               
               
                   
                   
                 Control 
                 66 
                 29.652 
                 31.720 
                 6.200 
                 168.28  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −12.330 
                 24.300 
                 — 
                 — 
               
               
                   
                 Coffee 
                 Ulcerative_Colitis 
                 57 
                 38.327 
                 69.479 
                 2.523 
                 400.00  
               
               
                   
                   
                 Control 
                 66 
                 29.631 
                 46.880 
                 5.215 
                 346.81  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 8.696 
                 58.436 
                 — 
                 — 
               
               
                   
                 Cola_Nut 
                 Ulcerative_Colitis 
                 57 
                 35.111 
                 16.941 
                 14.321  
                 94.417 
               
               
                   
                   
                 Control 
                 66 
                 29.138 
                 12.588 
                 8.723 
                 58.129 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 5.972 
                 14.763 
                 — 
                 — 
               
               
                   
                 Corn 
                 Ulcerative_Colitis 
                 57 
                 21.320 
                 39.276 
                 1.426 
                 231.14  
               
               
                   
                   
                 Control 
                 66 
                 11.407 
                 23.137 
                 0.100 
                 187.68  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 9.913 
                 31.646 
                 — 
                 — 
               
               
                   
                 Cottage_Ch —   
                 Ulcerative_Colitis 
                 57 
                 93.700 
                 117.494 
                 2.594 
                 400.00  
               
               
                   
                   
                 Control 
                 66 
                 76.158 
                 92.333 
                 0.100 
                 400.00  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 17.543 
                 104.732 
                 — 
                 — 
               
               
                   
                 Cow_Milk 
                 Ulcerative_Colitis 
                 57 
                 85.720 
                 104.244 
                 0.682 
                 400.00  
               
               
                   
                   
                 Control 
                 66 
                 75.882 
                 86.959 
                 0.100 
                 400.00  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 9.838 
                 95.349 
                 — 
                 — 
               
               
                   
                 Crab 
                 Ulcerative_Colitis 
                 57 
                 19.921 
                 13.939 
                 4.440 
                 70.735 
               
               
                   
                   
                 Control 
                 66 
                 23.583 
                 17.654 
                 3.803 
                 93.236 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −3.661 
                 16.042 
                 — 
                 — 
               
               
                   
                 Cucumber 
                 Ulcerative_Colitis 
                 57 
                 16.195 
                 18.948 
                 1.232 
                 120.91  
               
               
                   
                   
                 Control 
                 66 
                 8.461 
                 8.149 
                 0.100 
                 38.939 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 7.735 
                 14.207 
                 — 
                 — 
               
               
                   
                 Egg 
                 Ulcerative_Colitis 
                 57 
                 85.576 
                 122.235 
                 2.451 
                 400.00  
               
               
                   
                   
                 Control 
                 66 
                 55.102 
                 89.966 
                 0.100 
                 400.00  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 30.475 
                 106.127 
                 — 
                 — 
               
               
                   
                 Eggplant 
                 Ulcerative_Colitis 
                 57 
                 9.361 
                 12.488 
                 0.100 
                 69.989 
               
               
                   
                   
                 Control 
                 66 
                 5.732 
                 5.993 
                 0.100 
                 31.330 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 3.628 
                 9.564 
                 — 
                 — 
               
               
                   
                 Garlic 
                 Ulcerative_Colitis 
                 57 
                 20.485 
                 17.805 
                 2.413 
                 90.456 
               
               
                   
                   
                 Control 
                 66 
                 11.174 
                 5.779 
                 3.380 
                 28.482 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 9.310 
                 12.832 
                 — 
                 — 
               
               
                   
                 Goat_Milk 
                 Ulcerative_Colitis 
                 57 
                 13.970 
                 15.091 
                 1.146 
                 78.345 
               
               
                   
                   
                 Control 
                 66 
                 15.413 
                 28.452 
                 0.100 
                 180.08  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −1.443 
                 23.243 
                 — 
                 — 
               
               
                   
                 Grape 
                 Ulcerative_Colitis 
                 57 
                 20.135 
                 11.537 
                 4.169 
                 78.950 
               
               
                   
                   
                 Control 
                 66 
                 20.276 
                 6.827 
                 10.650  
                 47.817 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −0.141 
                 9.308 
                 — 
                 — 
               
               
                   
                 Grapefruit 
                 Ulcerative_Colitis 
                 57 
                 5.675 
                 9.301 
                 0.100 
                 68.905 
               
               
                   
                   
                 Control 
                 66 
                 3.278 
                 2.446 
                 0.100 
                 14.364 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 2.397 
                 6.576 
                 — 
                 — 
               
               
                   
                 Green_Pea 
                 Ulcerative_Colitis 
                 57 
                 15.251 
                 15.940 
                 0.658 
                 79.774 
               
               
                   
                   
                 Control 
                 66 
                 8.631 
                 7.160 
                 0.496 
                 32.502 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 6.620 
                 12.047 
                 — 
                 — 
               
               
                   
                 Green_Pepper 
                 Ulcerative_Colitis 
                 57 
                 7.641 
                 14.196 
                 0.100 
                 107.26  
               
               
                   
                   
                 Control 
                 66 
                 4.149 
                 2.875 
                 0.100 
                 14.364 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 3.492 
                 9.885 
                 — 
                 — 
               
               
                   
                 Halibut 
                 Ulcerative_Colitis 
                 57 
                 10.765 
                 5.076 
                 2.587 
                 27.746 
               
               
                   
                   
                 Control 
                 66 
                 11.119 
                 7.129 
                 2.729 
                 44.884 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −0.354 
                 6.263 
                 — 
                 — 
               
               
                   
                 Honey 
                 Ulcerative_Colitis 
                 57 
                 12.330 
                 7.625 
                 2.742 
                 37.290 
               
               
                   
                   
                 Control 
                 66 
                 10.185 
                 4.203 
                 4.227 
                 19.876 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 2.145 
                 6.033 
                 — 
                 — 
               
               
                   
                 Lemon 
                 Ulcerative_Colitis 
                 57 
                 3.296 
                 3.105 
                 0.100 
                 22.003 
               
               
                   
                   
                 Control 
                 66 
                 2.482 
                 2.159 
                 0.100 
                 14.688 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 0.814 
                 2.639 
                 — 
                 — 
               
               
                   
                 Lettuce 
                 Ulcerative_Colitis 
                 57 
                 11.835 
                 9.147 
                 2.711 
                 59.964 
               
               
                   
                   
                 Control 
                 66 
                 11.368 
                 6.472 
                 0.921 
                 29.851 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 0.467 
                 7.825 
                 — 
                 — 
               
               
                   
                 Lima_Bean 
                 Ulcerative_Colitis 
                 57 
                 10.268 
                 8.919 
                 0.329 
                 39.575 
               
               
                   
                   
                 Control 
                 66 
                 6.624 
                 8.761 
                 0.100 
                 65.634 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 3.643 
                 8.835 
                 — 
                 — 
               
               
                   
                 Lobster 
                 Ulcerative_Colitis 
                 57 
                 12.931 
                 10.997 
                 1.181 
                 62.481 
               
               
                   
                   
                 Control 
                 66 
                 13.398 
                 8.359 
                 3.938 
                 46.560 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −0.468 
                 9.670 
                 — 
                 — 
               
               
                   
                 Malt 
                 Ulcerative_Colitis 
                 57 
                 23.676 
                 17.406 
                 5.814 
                 105.68  
               
               
                   
                   
                 Control 
                 66 
                 21.743 
                 11.326 
                 3.684 
                 57.151 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 1.933 
                 14.461 
                 — 
                 — 
               
               
                   
                 Millet 
                 Ulcerative_Colitis 
                 57 
                 5.424 
                 5.233 
                 0.487 
                 27.187 
               
               
                   
                   
                 Control 
                 66 
                 4.889 
                 7.091 
                 0.100 
                 46.663 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 0.535 
                 6.299 
                 — 
                 — 
               
               
                   
                 Mushroom 
                 Ulcerative_Colitis 
                 57 
                 9.754 
                 12.339 
                 0.100 
                 69.107 
               
               
                   
                   
                 Control 
                 66 
                 13.174 
                 12.549 
                 1.117 
                 49.656 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −3.419 
                 12.452 
                 — 
                 — 
               
               
                   
                 Mustard 
                 Ulcerative_Colitis 
                 57 
                 11.854 
                 15.378 
                 2.545 
                 98.146 
               
               
                   
                   
                 Control 
                 66 
                 8.842 
                 5.224 
                 0.100 
                 23.452 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 3.011 
                 11.140 
                 — 
                 — 
               
               
                   
                 Oat 
                 Ulcerative_Colitis 
                 57 
                 40.965 
                 76.954 
                 0.768 
                 400.00  
               
               
                   
                   
                 Control 
                 66 
                 16.237 
                 14.506 
                 0.100 
                 76.165 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 24.727 
                 53.421 
                 — 
                 — 
               
               
                   
                 Olive 
                 Ulcerative_Colitis 
                 57 
                 31.615 
                 30.330 
                 3.573 
                 180.11  
               
               
                   
                   
                 Control 
                 66 
                 23.704 
                 14.281 
                 5.272 
                 59.488 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 7.911 
                 23.137 
                 — 
                 — 
               
               
                   
                 Onion 
                 Ulcerative_Colitis 
                 57 
                 17.905 
                 24.231 
                 0.438 
                 119.13  
               
               
                   
                   
                 Control 
                 66 
                 11.329 
                 16.935 
                 1.184 
                 114.37  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 6.576 
                 20.635 
                 — 
                 — 
               
               
                   
                 Orange 
                 Ulcerative_Colitis 
                 57 
                 26.028 
                 25.192 
                 1.206 
                 112.32  
               
               
                   
                   
                 Control 
                 66 
                 15.289 
                 11.608 
                 1.489 
                 47.125 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 10.738 
                 19.134 
                 — 
                 — 
               
               
                   
                 Oyster 
                 Ulcerative_Colitis 
                 57 
                 63.062 
                 63.526 
                 4.608 
                 372.89  
               
               
                   
                   
                 Control 
                 66 
                 42.674 
                 33.485 
                 5.656 
                 168.59  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 20.388 
                 49.699 
                 — 
                 — 
               
               
                   
                 Parsley 
                 Ulcerative_Colitis 
                 57 
                 6.938 
                 11.992 
                 0.100 
                 70.169 
               
               
                   
                   
                 Control 
                 66 
                 5.005 
                 6.541 
                 0.100 
                 34.932 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 1.933 
                 9.462 
                 — 
                 — 
               
               
                   
                 Peach 
                 Ulcerative_Colitis 
                 57 
                 13.457 
                 20.732 
                 0.123 
                 124.35  
               
               
                   
                   
                 Control 
                 66 
                 7.145 
                 7.742 
                 0.100 
                 33.820 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 6.312 
                 15.203 
                 — 
                 — 
               
               
                   
                 Peanut 
                 Ulcerative_Colitis 
                 57 
                 14.262 
                 48.433 
                 0.219 
                 349.73  
               
               
                   
                   
                 Control 
                 66 
                 5.563 
                 4.941 
                 0.100 
                 26.567 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 8.699 
                 33.147 
                 — 
                 — 
               
               
                   
                 Pineapple 
                 Ulcerative_Colitis 
                 57 
                 53.335 
                 86.808 
                 0.329 
                 400.00  
               
               
                   
                   
                 Control 
                 66 
                 23.710 
                 46.114 
                 0.100 
                 278.44  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 29.626 
                 68.044 
                 — 
                 — 
               
               
                   
                 Pinto_Bean 
                 Ulcerative_Colitis 
                 57 
                 16.597 
                 22.820 
                 2.254 
                 152.98  
               
               
                   
                   
                 Control 
                 66 
                 10.138 
                 8.167 
                 0.100 
                 48.623 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 6.459 
                 16.639 
                 — 
                 — 
               
               
                   
                 Pork 
                 Ulcerative_Colitis 
                 57 
                 15.004 
                 15.800 
                 2.962 
                 80.448 
               
               
                   
                   
                 Control 
                 66 
                 15.347 
                 10.345 
                 4.339 
                 65.759 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −0.343 
                 13.154 
                 — 
                 — 
               
               
                   
                 Potato 
                 Ulcerative_Colitis 
                 57 
                 17.934 
                 24.208 
                 4.278 
                 183.78  
               
               
                   
                   
                 Control 
                 66 
                 13.615 
                 6.063 
                 6.200 
                 40.802 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 4.318 
                 17.058 
                 — 
                 — 
               
               
                   
                 Rice 
                 Ulcerative_Colitis 
                 57 
                 31.549 
                 49.019 
                 6.184 
                 362.21  
               
               
                   
                   
                 Control 
                 66 
                 21.551 
                 16.950 
                 3.350 
                 92.642 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 9.998 
                 35.587 
                 — 
                 — 
               
               
                   
                 Rye 
                 Ulcerative_Colitis 
                 57 
                 6.931 
                 12.152 
                 1.338 
                 92.310 
               
               
                   
                   
                 Control 
                 66 
                 5.237 
                 3.633 
                 0.100 
                 22.824 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 1.694 
                 8.685 
                 — 
                 — 
               
               
                   
                 Safflower 
                 Ulcerative_Colitis 
                 57 
                 8.917 
                 6.880 
                 2.531 
                 41.242 
               
               
                   
                   
                 Control 
                 66 
                 8.776 
                 8.189 
                 1.722 
                 48.833 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 0.140 
                 7.611 
                 — 
                 — 
               
               
                   
                 Salmon 
                 Ulcerative_Colitis 
                 57 
                 9.369 
                 6.906 
                 2.413 
                 44.560 
               
               
                   
                   
                 Control 
                 66 
                 9.377 
                 7.261 
                 2.862 
                 56.530 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −0.008 
                 7.099 
                 − 
                 − 
               
               
                   
                 Sardine 
                 Ulcerative_Colitis 
                 57 
                 44.148 
                 20.802 
                 12.069  
                 102.96  
               
               
                   
                   
                 Control 
                 66 
                 37.084 
                 16.695 
                 7.190 
                 88.964 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 7.064 
                 18.708 
                 — 
                 — 
               
               
                   
                 Scallop 
                 Ulcerative_Colitis 
                 57 
                 61.726 
                 39.681 
                 14.451  
                 165.26  
               
               
                   
                   
                 Control 
                 66 
                 64.291 
                 29.551 
                 18.605  
                 148.58  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −2.565 
                 34.610 
                 — 
                 — 
               
               
                   
                 Sesame 
                 Ulcerative_Colitis 
                 57 
                 73.122 
                 118.220 
                 0.100 
                 400.00  
               
               
                   
                   
                 Control 
                 66 
                 80.704 
                 93.902 
                 5.984 
                 400.00  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −7.582 
                 105.854 
                 — 
                 — 
               
               
                   
                 Shrimp 
                 Ulcerative_Colitis 
                 57 
                 21.492 
                 22.231 
                 1.717 
                 137.49  
               
               
                   
                   
                 Control 
                 66 
                 33.150 
                 27.875 
                 6.607 
                 113.66  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −11.658 
                 25.419 
                 — 
                 — 
               
               
                   
                 Sole 
                 Ulcerative_Colitis 
                 57 
                 6.020 
                 3.293 
                 1.316 
                 20.885 
               
               
                   
                   
                 Control 
                 66 
                 6.440 
                 6.960 
                 0.100 
                 54.883 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −0.419 
                 5.571 
                 — 
                 — 
               
               
                   
                 Soybean 
                 Ulcerative_Colitis 
                 57 
                 21.445 
                 26.605 
                 4.187 
                 187.77  
               
               
                   
                   
                 Control 
                 66 
                 15.294 
                 9.373 
                 2.481 
                 49.071 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 6.151 
                 19.360 
                 — 
                 — 
               
               
                   
                 Spinach 
                 Ulcerative_Colitis 
                 57 
                 26.961 
                 49.539 
                 6.802 
                 367.99  
               
               
                   
                   
                 Control 
                 66 
                 20.485 
                 13.172 
                 6.051 
                 66.626 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 6.476 
                 35.057 
                 — 
                 — 
               
               
                   
                 Squashes 
                 Ulcerative_Colitis 
                 57 
                 17.555 
                 11.532 
                 4.059 
                 53.553 
               
               
                   
                   
                 Control 
                 66 
                 13.415 
                 11.597 
                 1.842 
                 74.279 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 4.140 
                 11.567 
                 — 
                 — 
               
               
                   
                 Strawberry 
                 Ulcerative_Colitis 
                 57 
                 6.064 
                 5.341 
                 0.100 
                 28.233 
               
               
                   
                   
                 Control 
                 66 
                 5.563 
                 5.305 
                 0.100 
                 35.745 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 0.501 
                 5.321 
                 — 
                 — 
               
               
                   
                 String_Bean 
                 Ulcerative_Colitis 
                 57 
                 54.019 
                 30.799 
                 7.680 
                 149.68  
               
               
                   
                   
                 Control 
                 66 
                 41.957 
                 22.678 
                 9.539 
                 125.69  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 12.063 
                 26.744 
                 — 
                 — 
               
               
                   
                 Sunflower_Sd 
                 Ulcerative_Colitis 
                 57 
                 15.717 
                 21.185 
                 2.084 
                 103.84  
               
               
                   
                   
                 Control 
                 66 
                 9.948 
                 6.094 
                 2.632 
                 33.347 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 5.769 
                 15.089 
                 — 
                 — 
               
               
                   
                 Sweet_Pot —   
                 Ulcerative_Colitis 
                 57 
                 13.118 
                 18.306 
                 2.218 
                 138.11  
               
               
                   
                   
                 Control 
                 66 
                 8.592 
                 4.479 
                 0.395 
                 25.009 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 4.525 
                 12.879 
                 — 
                 — 
               
               
                   
                 Swiss_Ch —   
                 Ulcerative_Colitis 
                 57 
                 49.090 
                 77.461 
                 2.316 
                 400.00  
               
               
                   
                   
                 Control 
                 66 
                 39.219 
                 73.725 
                 0.100 
                 400.00  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 9.871 
                 75.477 
                 — 
                 — 
               
               
                   
                 Tea 
                 Ulcerative_Colitis 
                 57 
                 35.381 
                 24.818 
                 12.508  
                 160.22  
               
               
                   
                   
                 Control 
                 66 
                 29.771 
                 12.014 
                 11.634  
                 64.535 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 5.610 
                 19.042 
                 — 
                 — 
               
               
                   
                 Tobacco 
                 Ulcerative_Colitis 
                 57 
                 39.527 
                 26.849 
                 10.906  
                 135.98  
               
               
                   
                   
                 Control 
                 66 
                 33.566 
                 16.789 
                 7.809 
                 82.097 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 5.961 
                 22.024 
                 — 
                 — 
               
               
                   
                 Tomato 
                 Ulcerative_Colitis 
                 57 
                 15.238 
                 16.813 
                 2.218 
                 107.39  
               
               
                   
                   
                 Control 
                 66 
                 9.066 
                 7.694 
                 0.100 
                 42.078 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 6.172 
                 12.753 
                 — 
                 — 
               
               
                   
                 Trout 
                 Ulcerative_Colitis 
                 57 
                 13.805 
                 8.087 
                 3.749 
                 47.896 
               
               
                   
                   
                 Control 
                 66 
                 16.138 
                 10.667 
                 5.596 
                 76.221 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −2.333 
                 9.560 
                 — 
                 — 
               
               
                   
                 Tuna 
                 Ulcerative_Colitis 
                 57 
                 15.838 
                 10.358 
                 2.254 
                 56.001 
               
               
                   
                   
                 Control 
                 66 
                 18.092 
                 12.707 
                 3.873 
                 64.090 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −2.253 
                 11.679 
                 — 
                 — 
               
               
                   
                 Turkey 
                 Ulcerative_Colitis 
                 57 
                 16.023 
                 14.275 
                 3.006 
                 95.919 
               
               
                   
                   
                 Control 
                 66 
                 14.461 
                 6.976 
                 4.094 
                 32.151 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 1.561 
                 10.975 
                 — 
                 — 
               
               
                   
                 Walnut_Blk 
                 Ulcerative_Colitis 
                 57 
                 40.389 
                 58.256 
                 8.009 
                 400.00  
               
               
                   
                   
                 Control 
                 66 
                 25.386 
                 17.254 
                 6.943 
                 117.46  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 15.003 
                 41.601 
                 — 
                 — 
               
               
                   
                 Wheat 
                 Ulcerative_Colitis 
                 57 
                 25.837 
                 67.552 
                 2.304 
                 400.00  
               
               
                   
                   
                 Control 
                 66 
                 18.402 
                 29.364 
                 0.790 
                 209.95  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 7.435 
                 50.746 
                 — 
                 — 
               
               
                   
                 Yeast_Baker 
                 Ulcerative_Colitis 
                 57 
                 12.519 
                 30.904 
                 1.316 
                 223.99  
               
               
                   
                   
                 Control 
                 66 
                 5.545 
                 3.349 
                 0.526 
                 18.811 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 6.974 
                 21.167 
                 — 
                 — 
               
               
                   
                 Yeast_Brewer 
                 Ulcerative_Colitis 
                 57 
                 25.350 
                 61.479 
                 2.194 
                 400.00  
               
               
                   
                   
                 Control 
                 66 
                 10.847 
                 7.818 
                 0.100 
                 43.887 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 14.503 
                 42.215 
                 — 
                 — 
               
               
                   
                 Yogurt 
                 Ulcerative_Colitis 
                 57 
                 21.430 
                 20.338 
                 4.240 
                 101.82  
               
               
                   
                   
                 Control 
                 66 
                 22.930 
                 30.973 
                 0.100 
                 215.73  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −1.500 
                 26.585 
                 — 
                 — 
               
               
                 MALE 
                 Almond 
                 Ulcerative_Colitis 
                 46 
                 9.713 
                 10.631 
                 0.100 
                 48.413 
               
               
                   
                   
                 Control 
                 97 
                 4.049 
                 2.231 
                 0.100 
                 12.591 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 5.664 
                 6.282 
                 — 
                 — 
               
               
                   
                 Amer_Cheese 
                 Ulcerative_Colitis 
                 46 
                 27.588 
                 27.243 
                 0.100 
                 105.40  
               
               
                   
                   
                 Control 
                 97 
                 22.619 
                 34.069 
                 0.468 
                 197.38  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 4.969 
                 32.049 
                 — 
                 — 
               
               
                   
                 Apple 
                 Ulcerative_Colitis 
                 46 
                 5.840 
                 4.036 
                 0.100 
                 20.284 
               
               
                   
                   
                 Control 
                 97 
                 4.383 
                 2.900 
                 0.100 
                 13.795 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 1.457 
                 3.305 
                 — 
                 — 
               
               
                   
                 Avocado 
                 Ulcerative_Colitis 
                 46 
                 3.569 
                 2.010 
                 0.100 
                 11.275 
               
               
                   
                   
                 Control 
                 97 
                 2.720 
                 2.992 
                 0.100 
                 28.693 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 0.849 
                 2.717 
                 — 
                 — 
               
               
                   
                 Banana 
                 Ulcerative_Colitis 
                 46 
                 11.987 
                 18.952 
                 0.100 
                 96.512 
               
               
                   
                   
                 Control 
                 97 
                 8.576 
                 36.151 
                 0.100 
                 350.69  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 3.411 
                 31.693 
                 — 
                 — 
               
               
                   
                 Barley 
                 Ulcerative_Colitis 
                 46 
                 37.135 
                 58.378 
                 0.100 
                 400.00  
               
               
                   
                   
                 Control 
                 97 
                 19.214 
                 11.923 
                 4.612 
                 58.865 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 17.921 
                 34.416 
                 — 
                 — 
               
               
                   
                 Beef 
                 Ulcerative_Colitis 
                 46 
                 12.163 
                 15.192 
                 0.100 
                 89.210 
               
               
                   
                   
                 Control 
                 97 
                 9.327 
                 11.981 
                 2.059 
                 93.494 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 2.836 
                 13.092 
                 — 
                 — 
               
               
                   
                 Blueberry 
                 Ulcerative_Colitis 
                 46 
                 6.305 
                 4.453 
                 0.100 
                 26.859 
               
               
                   
                   
                 Control 
                 97 
                 5.393 
                 2.868 
                 0.100 
                 19.410 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 0.911 
                 3.454 
                 — 
                 — 
               
               
                   
                 Broccoli 
                 Ulcerative_Colitis 
                 46 
                 10.771 
                 6.468 
                 0.100 
                 29.342 
               
               
                   
                   
                 Control 
                 97 
                 6.790 
                 8.012 
                 0.131 
                 72.543 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 3.981 
                 7.554 
                 — 
                 — 
               
               
                   
                 Buck_Wheat 
                 Ulcerative_Colitis 
                 46 
                 9.904 
                 5.030 
                 0.100 
                 23.189 
               
               
                   
                   
                 Control 
                 97 
                 6.978 
                 3.384 
                 2.656 
                 24.338 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 2.926 
                 3.984 
                 — 
                 — 
               
               
                   
                 Butter 
                 Ulcerative_Colitis 
                 46 
                 28.310 
                 23.146 
                 2.104 
                 87.745 
               
               
                   
                   
                 Control 
                 97 
                 17.846 
                 20.091 
                 1.490 
                 131.60  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 10.464 
                 21.114 
                 — 
                 — 
               
               
                   
                 Cabbage 
                 Ulcerative_Colitis 
                 46 
                 11.079 
                 9.922 
                 0.100 
                 41.324 
               
               
                   
                   
                 Control 
                 97 
                 6.540 
                 18.133 
                 0.100 
                 174.96  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 4.539 
                 15.977 
                 — 
                 — 
               
               
                   
                 Cane_Sugar 
                 Ulcerative_Colitis 
                 46 
                 28.481 
                 24.975 
                 2.955 
                 147.61  
               
               
                   
                   
                 Control 
                 97 
                 22.356 
                 18.718 
                 2.789 
                 100.82  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 6.125 
                 20.919 
                 — 
                 — 
               
               
                   
                 Cantaloupe 
                 Ulcerative_Colitis 
                 46 
                 12.177 
                 10.882 
                 0.100 
                 60.013 
               
               
                   
                   
                 Control 
                 97 
                 6.052 
                 5.569 
                 0.468 
                 38.706 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 6.126 
                 7.675 
                 — 
                 — 
               
               
                   
                 Carrot 
                 Ulcerative_Colitis 
                 46 
                 9.182 
                 8.539 
                 0.100 
                 50.970 
               
               
                   
                   
                 Control 
                 97 
                 4.684 
                 3.636 
                 0.468 
                 28.593 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 4.498 
                 5.681 
                 — 
                 — 
               
               
                   
                 Cashew 
                 Ulcerative_Colitis 
                 46 
                 17.599 
                 28.317 
                 0.100 
                 167.72  
               
               
                   
                   
                 Control 
                 97 
                 8.362 
                 10.271 
                 0.100 
                 55.749 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 9.237 
                 18.103 
                 — 
                 — 
               
               
                   
                 Cauliflower 
                 Ulcerative_Colitis 
                 46 
                 9.803 
                 9.337 
                 0.100 
                 42.378 
               
               
                   
                   
                 Control 
                 97 
                 4.385 
                 4.396 
                 0.100 
                 36.593 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 5.418 
                 6.402 
                 — 
                 — 
               
               
                   
                 Celery 
                 Ulcerative_Colitis 
                 46 
                 16.290 
                 11.968 
                 0.100 
                 52.534 
               
               
                   
                   
                 Control 
                 97 
                 8.930 
                 4.985 
                 2.394 
                 26.982 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 7.360 
                 7.914 
                 — 
                 — 
               
               
                   
                 Cheddar_Ch —   
                 Ulcerative_Colitis 
                 46 
                 41.438 
                 45.998 
                 0.100 
                 208.47  
               
               
                   
                   
                 Control 
                 97 
                 28.479 
                 49.022 
                 1.169 
                 298.91  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 12.959 
                 48.077 
                 — 
                 — 
               
               
                   
                 Chicken 
                 Ulcerative_Colitis 
                 46 
                 21.425 
                 15.312 
                 0.100 
                 71.379 
               
               
                   
                   
                 Control 
                 97 
                 17.778 
                 11.456 
                 5.137 
                 69.503 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 3.646 
                 12.813 
                 — 
                 — 
               
               
                   
                 Chili_Pepper 
                 Ulcerative_Colitis 
                 46 
                 13.087 
                 11.692 
                 0.100 
                 61.496 
               
               
                   
                   
                 Control 
                 97 
                 7.802 
                 5.945 
                 1.591 
                 31.070 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 5.286 
                 8.227 
                 — 
                 — 
               
               
                   
                 Chocolate 
                 Ulcerative_Colitis 
                 46 
                 20.511 
                 13.811 
                 0.100 
                 69.232 
               
               
                   
                   
                 Control 
                 97 
                 16.536 
                 11.276 
                 1.726 
                 63.673 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 3.975 
                 12.143 
                 — 
                 — 
               
               
                   
                 Cinnamon 
                 Ulcerative_Colitis 
                 46 
                 43.331 
                 30.200 
                 7.718 
                 117.58  
               
               
                   
                   
                 Control 
                 97 
                 35.928 
                 28.520 
                 3.136 
                 146.95  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 7.403 
                 29.067 
                 — 
                 — 
               
               
                   
                 Clam 
                 Ulcerative_Colitis 
                 46 
                 38.009 
                 28.872 
                 3.421 
                 121.47  
               
               
                   
                   
                 Control 
                 97 
                 38.293 
                 21.598 
                 6.370 
                 103.47  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −0.284 
                 24.159 
                 — 
                 — 
               
               
                   
                 Codfish 
                 Ulcerative_Colitis 
                 46 
                 26.039 
                 20.205 
                 0.100 
                 86.059 
               
               
                   
                   
                 Control 
                 97 
                 22.538 
                 29.644 
                 4.176 
                 269.16  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 3.501 
                 26.992 
                 — 
                 — 
               
               
                   
                 Coffee 
                 Ulcerative_Colitis 
                 46 
                 34.715 
                 62.443 
                 3.884 
                 400.00  
               
               
                   
                   
                 Control 
                 97 
                 20.037 
                 24.002 
                 2.705 
                 192.24  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 14.679 
                 40.455 
                 — 
                 — 
               
               
                   
                 Cola_Nut 
                 Ulcerative_Colitis 
                 46 
                 38.888 
                 16.023 
                 11.891  
                 84.315 
               
               
                   
                   
                 Control 
                 97 
                 32.919 
                 20.025 
                 3.851 
                 112.10  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 5.969 
                 18.840 
                 — 
                 — 
               
               
                   
                 Corn 
                 Ulcerative_Colitis 
                 46 
                 13.329 
                 9.353 
                 0.100 
                 53.955 
               
               
                   
                   
                 Control 
                 97 
                 10.126 
                 15.048 
                 1.520 
                 117.90  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 3.203 
                 13.494 
                 — 
                 — 
               
               
                   
                 Cottage_Ch —   
                 Ulcerative_Colitis 
                 46 
                 127.105 
                 127.624 
                 1.867 
                 400.00  
               
               
                   
                   
                 Control 
                 97 
                 74.814 
                 101.386 
                 1.446 
                 400.00  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 52.292 
                 110.439 
                 — 
                 — 
               
               
                   
                 Cow_Milk 
                 Ulcerative_Colitis 
                 46 
                 115.427 
                 111.909 
                 2.595 
                 400.00  
               
               
                   
                   
                 Control 
                 97 
                 68.606 
                 94.032 
                 1.343 
                 400.00  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 46.821 
                 100.085 
                 — 
                 — 
               
               
                   
                 Crab 
                 Ulcerative_Colitis 
                 46 
                 29.571 
                 61.851 
                 2.104 
                 400.00  
               
               
                   
                   
                 Control 
                 97 
                 24.550 
                 29.311 
                 3.108 
                 252.41  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 5.021 
                 42.496 
                 — 
                 — 
               
               
                   
                 Cucumber 
                 Ulcerative_Colitis 
                 46 
                 13.314 
                 9.189 
                 0.100 
                 39.378 
               
               
                   
                   
                 Control 
                 97 
                 8.320 
                 9.298 
                 0.234 
                 69.188 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 4.994 
                 9.263 
                 — 
                 — 
               
               
                   
                 Egg 
                 Ulcerative_Colitis 
                 46 
                 71.044 
                 98.867 
                 0.935 
                 400.00  
               
               
                   
                   
                 Control 
                 97 
                 44.335 
                 66.828 
                 0.100 
                 400.00  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 26.709 
                 78.487 
                 — 
                 — 
               
               
                   
                 Eggplant 
                 Ulcerative_Colitis 
                 46 
                 8.891 
                 11.349 
                 0.100 
                 74.721 
               
               
                   
                   
                 Control 
                 97 
                 5.856 
                 10.455 
                 0.100 
                 92.376 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 3.035 
                 10.749 
                 — 
                 — 
               
               
                   
                 Garlic 
                 Ulcerative_Colitis 
                 46 
                 17.749 
                 14.628 
                 0.100 
                 72.515 
               
               
                   
                   
                 Control 
                 97 
                 13.476 
                 12.122 
                 3.097 
                 70.591 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 4.274 
                 12.975 
                 — 
                 — 
               
               
                   
                 Goat_Milk 
                 Ulcerative_Colitis 
                 46 
                 21.482 
                 21.250 
                 0.100 
                 81.830 
               
               
                   
                   
                 Control 
                 97 
                 17.999 
                 36.202 
                 0.100 
                 275.19  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 3.483 
                 32.194 
                 — 
                 — 
               
               
                   
                 Grape 
                 Ulcerative_Colitis 
                 46 
                 22.888 
                 11.749 
                 0.100 
                 71.188 
               
               
                   
                   
                 Control 
                 97 
                 23.308 
                 7.422 
                 11.900  
                 41.654 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −0.420 
                 9.031 
                 — 
                 — 
               
               
                   
                 Grapefruit 
                 Ulcerative_Colitis 
                 46 
                 5.464 
                 4.181 
                 0.100 
                 20.502 
               
               
                   
                   
                 Control 
                 97 
                 3.049 
                 2.306 
                 0.100 
                 14.648 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 2.415 
                 3.033 
                 — 
                 — 
               
               
                   
                 Green_Pea 
                 Ulcerative_Colitis 
                 46 
                 19.698 
                 18.404 
                 0.100 
                 78.678 
               
               
                   
                   
                 Control 
                 97 
                 9.229 
                 11.366 
                 0.100 
                 71.765 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 10.469 
                 14.002 
                 — 
                 — 
               
               
                   
                 Green_Pepper 
                 Ulcerative_Colitis 
                 46 
                 7.397 
                 6.122 
                 0.100 
                 27.348 
               
               
                   
                   
                 Control 
                 97 
                 3.972 
                 2.664 
                 0.100 
                 15.744 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 3.425 
                 4.098 
                 — 
                 — 
               
               
                   
                 Halibut 
                 Ulcerative_Colitis 
                 46 
                 14.268 
                 13.472 
                 0.100 
                 81.343 
               
               
                   
                   
                 Control 
                 97 
                 12.657 
                 15.451 
                 0.818 
                 142.09  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 1.611 
                 14.848 
                 — 
                 — 
               
               
                   
                 Honey 
                 Ulcerative_Colitis 
                 46 
                 12.703 
                 6.605 
                 0.100 
                 33.490 
               
               
                   
                   
                 Control 
                 97 
                 11.082 
                 6.215 
                 2.434 
                 31.202 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 1.620 
                 6.343 
                 — 
                 — 
               
               
                   
                 Lemon 
                 Ulcerative_Colitis 
                 46 
                 3.113 
                 1.709 
                 0.100 
                  7.749 
               
               
                   
                   
                 Control 
                 97 
                 2.310 
                 1.436 
                 0.100 
                  8.383 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 0.803 
                 1.528 
                 — 
                 — 
               
               
                   
                 Lettuce 
                 Ulcerative_Colitis 
                 46 
                 12.892 
                 7.188 
                 0.100 
                 29.846 
               
               
                   
                   
                 Control 
                 97 
                 11.271 
                 8.295 
                 2.871 
                 52.209 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 1.621 
                 7.958 
                 — 
                 — 
               
               
                   
                 Lima_Bean 
                 Ulcerative_Colitis 
                 46 
                 8.928 
                 5.835 
                 0.100 
                 29.759 
               
               
                   
                   
                 Control 
                 97 
                 5.994 
                 5.650 
                 0.100 
                 37.640 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 2.934 
                 5.710 
                 — 
                 — 
               
               
                   
                 Lobster 
                 Ulcerative_Colitis 
                 46 
                 11.944 
                 7.361 
                 0.117 
                 37.739 
               
               
                   
                   
                 Control 
                 97 
                 15.678 
                 11.555 
                 0.468 
                 61.064 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −3.734 
                 10.402 
                 — 
                 — 
               
               
                   
                 Malt 
                 Ulcerative_Colitis 
                 46 
                 26.092 
                 17.394 
                 0.100 
                 105.54  
               
               
                   
                   
                 Control 
                 97 
                 21.137 
                 12.373 
                 3.182 
                 58.638 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 4.955 
                 14.170 
                 — 
                 — 
               
               
                   
                 Millet 
                 Ulcerative_Colitis 
                 46 
                 5.919 
                 7.006 
                 0.100 
                 42.933 
               
               
                   
                   
                 Control 
                 97 
                 4.006 
                 6.783 
                 0.100 
                 67.831 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 1.913 
                 6.855 
                 — 
                 — 
               
               
                   
                 Mushroom 
                 Ulcerative_Colitis 
                 46 
                 14.755 
                 16.831 
                 0.100 
                 68.603 
               
               
                   
                   
                 Control 
                 97 
                 12.883 
                 12.397 
                 1.350 
                 59.949 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 1.873 
                 13.966 
                 — 
                 — 
               
               
                   
                 Mustard 
                 Ulcerative_Colitis 
                 46 
                 17.526 
                 26.970 
                 1.089 
                 183.13  
               
               
                   
                   
                 Control 
                 97 
                 9.168 
                 5.413 
                 1.044 
                 28.538 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 8.358 
                 15.878 
                 — 
                 — 
               
               
                   
                 Oat 
                 Ulcerative_Colitis 
                 46 
                 29.789 
                 33.374 
                 0.100 
                 193.73  
               
               
                   
                   
                 Control 
                 97 
                 20.964 
                 22.946 
                 1.461 
                 107.25  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 8.825 
                 26.720 
                 — 
                 — 
               
               
                   
                 Olive 
                 Ulcerative_Colitis 
                 46 
                 30.506 
                 20.247 
                 0.139 
                 118.07  
               
               
                   
                   
                 Control 
                 97 
                 24.794 
                 22.708 
                 5.137 
                 160.63  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 5.711 
                 21.952 
                 — 
                 — 
               
               
                   
                 Onion 
                 Ulcerative_Colitis 
                 46 
                 14.182 
                 12.107 
                 0.100 
                 50.545 
               
               
                   
                   
                 Control 
                 97 
                 11.600 
                 17.551 
                 1.175 
                 158.57  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 2.583 
                 16.016 
                 — 
                 — 
               
               
                   
                 Orange 
                 Ulcerative_Colitis 
                 46 
                 28.800 
                 21.379 
                 0.100 
                 110.43  
               
               
                   
                   
                 Control 
                 97 
                 17.767 
                 16.361 
                 2.146 
                 79.419 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 11.034 
                 18.114 
                 — 
                 — 
               
               
                   
                 Oyster 
                 Ulcerative_Colitis 
                 46 
                 63.323 
                 74.746 
                 6.369 
                 357.39  
               
               
                   
                   
                 Control 
                 97 
                 43.016 
                 35.689 
                 5.069 
                 216.58  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 20.306 
                 51.481 
                 — 
                 — 
               
               
                   
                 Parsley 
                 Ulcerative_Colitis 
                 46 
                 9.862 
                 16.304 
                 0.100 
                 74.199 
               
               
                   
                   
                 Control 
                 97 
                 4.867 
                 7.352 
                 0.100 
                 58.674 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 4.995 
                 11.029 
                 — 
                 — 
               
               
                   
                 Peach 
                 Ulcerative_Colitis 
                 46 
                 16.604 
                 35.101 
                 0.100 
                 236.47  
               
               
                   
                   
                 Control 
                 97 
                 8.390 
                 8.373 
                 0.100 
                 50.444 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 8.214 
                 20.999 
                 — 
                 — 
               
               
                   
                 Peanut 
                 Ulcerative_Colitis 
                 46 
                 8.452 
                 9.914 
                 0.100 
                 51.491 
               
               
                   
                   
                 Control 
                 97 
                 4.241 
                 4.514 
                 0.855 
                 41.070 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 4.211 
                 6.726 
                 — 
                 — 
               
               
                   
                 Pineapple 
                 Ulcerative_Colitis 
                 46 
                 34.321 
                 47.506 
                 0.100 
                 207.41  
               
               
                   
                   
                 Control 
                 97 
                 23.259 
                 48.769 
                 0.100 
                 400.00  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 11.061 
                 48.370 
                 — 
                 — 
               
               
                   
                 Pinto_Bean 
                 Ulcerative_Colitis 
                 46 
                 14.680 
                 10.767 
                 0.100 
                 49.004 
               
               
                   
                   
                 Control 
                 97 
                 8.132 
                 5.524 
                 0.664 
                 28.288 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 6.548 
                 7.601 
                 — 
                 — 
               
               
                   
                 Pork 
                 Ulcerative_Colitis 
                 46 
                 14.508 
                 12.409 
                 0.100 
                 73.385 
               
               
                   
                   
                 Control 
                 97 
                 13.403 
                 10.218 
                 1.637 
                 57.274 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 1.106 
                 10.965 
                 — 
                 — 
               
               
                   
                 Potato 
                 Ulcerative_Colitis 
                 46 
                 18.153 
                 11.266 
                 0.100 
                 55.737 
               
               
                   
                   
                 Control 
                 97 
                 14.555 
                 5.951 
                 5.259 
                 49.002 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 3.598 
                 8.039 
                 — 
                 — 
               
               
                   
                 Rice 
                 Ulcerative_Colitis 
                 46 
                 43.673 
                 60.315 
                 1.867 
                 400.00  
               
               
                   
                   
                 Control 
                 97 
                 25.220 
                 18.948 
                 5.149 
                 118.12  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 18.453 
                 37.490 
                 — 
                 — 
               
               
                   
                 Rye 
                 Ulcerative_Colitis 
                 46 
                 11.156 
                 18.678 
                 0.100 
                 113.72  
               
               
                   
                   
                 Control 
                 97 
                 4.801 
                 2.690 
                 0.653 
                 15.288 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 6.355 
                 10.783 
                 — 
                 — 
               
               
                   
                 Safflower 
                 Ulcerative_Colitis 
                 46 
                 9.950 
                 6.790 
                 0.100 
                 33.143 
               
               
                   
                   
                 Control 
                 97 
                 8.672 
                 6.177 
                 1.958 
                 38.914 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 1.278 
                 6.379 
                 — 
                 — 
               
               
                   
                 Salmon 
                 Ulcerative_Colitis 
                 46 
                 9.627 
                 5.825 
                 0.100 
                 28.441 
               
               
                   
                   
                 Control 
                 97 
                 10.920 
                 13.350 
                 0.100 
                 125.74  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −1.293 
                 11.496 
                 — 
                 — 
               
               
                   
                 Sardine 
                 Ulcerative_Colitis 
                 46 
                 48.386 
                 21.967 
                 10.375  
                 121.32  
               
               
                   
                   
                 Control 
                 97 
                 37.035 
                 15.979 
                 7.037 
                 90.406 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 11.351 
                 18.106 
                 — 
                 — 
               
               
                   
                 Scallop 
                 Ulcerative_Colitis 
                 46 
                 81.379 
                 44.060 
                 12.717  
                 186.86  
               
               
                   
                   
                 Control 
                 97 
                 60.721 
                 32.618 
                 8.942 
                 167.75  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 20.658 
                 36.660 
                 — 
                 — 
               
               
                   
                 Sesame 
                 Ulcerative_Colitis 
                 46 
                 72.997 
                 95.118 
                 0.100 
                 400.00  
               
               
                   
                   
                 Control 
                 97 
                 60.406 
                 79.861 
                 2.115 
                 400.00  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 12.592 
                 85.028 
                 — 
                 — 
               
               
                   
                 Shrimp 
                 Ulcerative_Colitis 
                 46 
                 22.090 
                 14.510 
                 2.955 
                 63.471 
               
               
                   
                   
                 Control 
                 97 
                 34.490 
                 42.689 
                 2.663 
                 342.67  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −12.400 
                 36.165 
                 — 
                 — 
               
               
                   
                 Sole 
                 Ulcerative_Colitis 
                 46 
                 7.515 
                 4.149 
                 0.100 
                 20.953 
               
               
                   
                   
                 Control 
                 97 
                 4.912 
                 2.238 
                 0.100 
                 14.303 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 2.603 
                 2.984 
                 — 
                 — 
               
               
                   
                 Soybean 
                 Ulcerative_Colitis 
                 46 
                 26.364 
                 27.186 
                 0.778 
                 141.84  
               
               
                   
                   
                 Control 
                 97 
                 15.880 
                 9.273 
                 4.912 
                 71.264 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 10.484 
                 17.159 
                 — 
                 — 
               
               
                   
                 Spinach 
                 Ulcerative_Colitis 
                 46 
                 24.393 
                 17.724 
                 2.770 
                 95.908 
               
               
                   
                   
                 Control 
                 97 
                 14.656 
                 7.304 
                 3.054 
                 39.867 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 9.737 
                 11.687 
                 — 
                 — 
               
               
                   
                 Squashes 
                 Ulcerative_Colitis 
                 46 
                 18.247 
                 11.663 
                 0.100 
                 50.213 
               
               
                   
                   
                 Control 
                 97 
                 12.688 
                 7.539 
                 1.637 
                 49.775 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 5.558 
                 9.062 
                 — 
                 — 
               
               
                   
                 Strawberry 
                 Ulcerative_Colitis 
                 46 
                 6.490 
                 5.578 
                 0.100 
                 34.770 
               
               
                   
                   
                 Control 
                 97 
                 4.767 
                 4.446 
                 0.100 
                 30.664 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 1.724 
                 4.836 
                 — 
                 — 
               
               
                   
                 String_Bean 
                 Ulcerative_Colitis 
                 46 
                 59.790 
                 51.398 
                 4.432 
                 325.08  
               
               
                   
                   
                 Control 
                 97 
                 40.720 
                 22.088 
                 5.609 
                 141.76  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 19.070 
                 34.283 
                 — 
                 — 
               
               
                   
                 Sunflower_Sd 
                 Ulcerative_Colitis 
                 46 
                 21.265 
                 47.116 
                 0.100 
                 326.78  
               
               
                   
                   
                 Control 
                 97 
                 9.071 
                 5.842 
                 2.523 
                 46.948 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 12.193 
                 27.050 
                 — 
                 — 
               
               
                   
                 Sweet_Pot —   
                 Ulcerative_Colitis 
                 46 
                 13.540 
                 9.152 
                 0.100 
                 38.861 
               
               
                   
                   
                 Control 
                 97 
                 8.456 
                 4.878 
                 0.100 
                 30.052 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 5.084 
                 6.552 
                 — 
                 — 
               
               
                   
                 Swiss_Ch —   
                 Ulcerative_Colitis 
                 46 
                 62.321 
                 76.987 
                 0.100 
                 353.99  
               
               
                   
                   
                 Control 
                 97 
                 43.413 
                 79.791 
                 0.100 
                 400.00  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 18.908 
                 78.907 
                 — 
                 — 
               
               
                   
                 Tea 
                 Ulcerative_Colitis 
                 46 
                 34.993 
                 14.697 
                 8.857 
                 76.433 
               
               
                   
                   
                 Control 
                 97 
                 31.353 
                 13.716 
                 8.890 
                 70.271 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 3.640 
                 14.036 
                 — 
                 — 
               
               
                   
                 Tobacco 
                 Ulcerative_Colitis 
                 46 
                 52.669 
                 54.079 
                 10.677  
                 354.77  
               
               
                   
                   
                 Control 
                 97 
                 39.354 
                 26.787 
                 6.106 
                 134.30  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 13.315 
                 37.708 
                 — 
                 — 
               
               
                   
                 Tomato 
                 Ulcerative_Colitis 
                 46 
                 19.627 
                 43.625 
                 0.100 
                 301.96  
               
               
                   
                   
                 Control 
                 97 
                 9.088 
                 7.957 
                 0.100 
                 48.338 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 10.539 
                 25.504 
                 — 
                 — 
               
               
                   
                 Trout 
                 Ulcerative_Colitis 
                 46 
                 17.035 
                 10.017 
                 0.100 
                 57.313 
               
               
                   
                   
                 Control 
                 97 
                 16.891 
                 15.673 
                 0.100 
                 144.46  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 0.144 
                 14.116 
                 — 
                 — 
               
               
                   
                 Tuna 
                 Ulcerative_Colitis 
                 46 
                 17.635 
                 11.232 
                 0.100 
                 48.815 
               
               
                   
                   
                 Control 
                 97 
                 18.392 
                 16.755 
                 3.156 
                 110.69  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 −0.757 
                 15.211 
                 — 
                 — 
               
               
                   
                 Turkey 
                 Ulcerative_Colitis 
                 46 
                 17.700 
                 13.152 
                 0.100 
                 60.557 
               
               
                   
                   
                 Control 
                 97 
                 14.840 
                 10.829 
                 2.789 
                 69.572 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 2.860 
                 11.621 
                 — 
                 — 
               
               
                   
                 Walnut_Blk 
                 Ulcerative_Colitis 
                 46 
                 41.473 
                 31.581 
                 2.178 
                 146.59  
               
               
                   
                   
                 Control 
                 97 
                 25.520 
                 14.492 
                 4.249 
                 71.927 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 15.952 
                 21.478 
                 — 
                 — 
               
               
                   
                 Wheat 
                 Ulcerative_Colitis 
                 46 
                 46.983 
                 93.083 
                 0.100 
                 400.00  
               
               
                   
                   
                 Control 
                 97 
                 14.494 
                 12.413 
                 2.741 
                 90.037 
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 32.489 
                 53.574 
                 — 
                 — 
               
               
                   
                 Yeast_Baker 
                 Ulcerative_Colitis 
                 46 
                 11.891 
                 14.388 
                 0.100 
                 81.470 
               
               
                   
                   
                 Control 
                 97 
                 9.617 
                 17.250 
                 1.305 
                 116.43  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 2.273 
                 16.391 
                 — 
                 — 
               
               
                   
                 Yeast_Brewer 
                 Ulcerative_Colitis 
                 46 
                 25.256 
                 36.449 
                 0.100 
                 190.55  
               
               
                   
                   
                 Control 
                 97 
                 22.646 
                 47.630 
                 1.931 
                 308.34  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 2.611 
                 44.369 
                 — 
                 — 
               
               
                   
                 Yogurt 
                 Ulcerative_Colitis 
                 46 
                 27.628 
                 20.117 
                 0.100 
                 77.470 
               
               
                   
                   
                 Control 
                 97 
                 19.210 
                 20.751 
                 0.234 
                 120.51  
               
               
                   
                   
                 Diff (1-2) 
                 — 
                 8.418 
                 20.551 
                 — 
                 — 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 Upper Quantiles of ELISA Signal Scores among Control Subjects as 
               
               
                 Candidates for Test Cutpoints in Determining “Positive” or “Negative” 
               
               
                 Top 58 Foods Ranked by Descending order of Discriminatory Ability 
               
               
                 using Permutation Test Ulcerative_Colitis Subjects vs. Controls 
               
            
           
           
               
               
            
               
                   
                 Cutpoint 
               
            
           
           
               
               
               
               
               
            
               
                 Food 
                   
                   
                 90th 
                 95th 
               
               
                 Ranking 
                 Food 
                 Sex 
                 percentile 
                 percentile 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 1 
                 Green_Pea 
                 FEMALE 
                 20.814 
                 23.684 
               
               
                   
                   
                 MALE 
                 19.788 
                 32.100 
               
               
                 2 
                 Cantaloupe 
                 FEMALE 
                 9.672 
                 13.552 
               
               
                   
                   
                 MALE 
                 11.337 
                 16.219 
               
               
                 3 
                 Pinto_Bean 
                 FEMALE 
                 18.863 
                 27.923 
               
               
                   
                   
                 MALE 
                 16.119 
                 20.774 
               
               
                 4 
                 Cucumber 
                 FEMALE 
                 20.944 
                 26.779 
               
               
                   
                   
                 MALE 
                 17.891 
                 23.472 
               
               
                 5 
                 Green_Pepper 
                 FEMALE 
                 8.275 
                 10.402 
               
               
                   
                   
                 MALE 
                 7.054 
                 9.712 
               
               
                 6 
                 Grapefruit 
                 FEMALE 
                 6.215 
                 7.611 
               
               
                   
                   
                 MALE 
                 5.330 
                 7.738 
               
               
                 7 
                 Carrot 
                 FEMALE 
                 9.212 
                 11.448 
               
               
                   
                   
                 MALE 
                 7.807 
                 10.836 
               
               
                 8 
                 Orange 
                 FEMALE 
                 33.707 
                 40.739 
               
               
                   
                   
                 MALE 
                 37.082 
                 56.031 
               
               
                 9 
                 Almond 
                 FEMALE 
                 6.751 
                 8.235 
               
               
                   
                   
                 MALE 
                 7.259 
                 8.824 
               
               
                 10 
                 Sardine 
                 FEMALE 
                 58.683 
                 73.442 
               
               
                   
                   
                 MALE 
                 57.359 
                 64.811 
               
               
                 11 
                 Sweet_Pot —   
                 FEMALE 
                 14.644 
                 17.301 
               
               
                   
                   
                 MALE 
                 13.894 
                 18.378 
               
               
                 12 
                 Broccoli 
                 FEMALE 
                 11.826 
                 14.843 
               
               
                   
                   
                 MALE 
                 13.203 
                 15.982 
               
               
                 13 
                 Garlic 
                 FEMALE 
                 19.323 
                 22.695 
               
               
                   
                   
                 MALE 
                 27.228 
                 41.008 
               
               
                 14 
                 Lima_Bean 
                 FEMALE 
                 12.667 
                 18.798 
               
               
                   
                   
                 MALE 
                 10.738 
                 14.912 
               
               
                 15 
                 Squashes 
                 FEMALE 
                 22.217 
                 32.815 
               
               
                   
                   
                 MALE 
                 22.931 
                 26.147 
               
               
                 16 
                 Celery 
                 FEMALE 
                 17.085 
                 22.342 
               
               
                   
                   
                 MALE 
                 15.101 
                 19.687 
               
               
                 17 
                 String_Bean 
                 FEMALE 
                 68.618 
                 84.869 
               
               
                   
                   
                 MALE 
                 65.384 
                 83.179 
               
               
                 18 
                 Tomato 
                 FEMALE 
                 17.721 
                 23.905 
               
               
                   
                   
                 MALE 
                 18.818 
                 26.329 
               
               
                 19 
                 Cauliflower 
                 FEMALE 
                 11.527 
                 17.829 
               
               
                   
                   
                 MALE 
                 8.004 
                 11.222 
               
               
                 20 
                 Walnut_Blk 
                 FEMALE 
                 45.008 
                 56.778 
               
               
                   
                   
                 MALE 
                 45.356 
                 56.848 
               
               
                 21 
                 Sunflower_Sd 
                 FEMALE 
                 16.611 
                 22.529 
               
               
                   
                   
                 MALE 
                 14.239 
                 18.733 
               
               
                 22 
                 Cane_Sugar 
                 FEMALE 
                 29.824 
                 36.249 
               
               
                   
                   
                 MALE 
                 45.468 
                 64.941 
               
               
                 23 
                 Buck_Wheat 
                 FEMALE 
                 14.739 
                 18.482 
               
               
                   
                   
                 MALE 
                 11.356 
                 12.773 
               
               
                 24 
                 Soybean 
                 FEMALE 
                 30.770 
                 34.674 
               
               
                   
                   
                 MALE 
                 26.301 
                 31.395 
               
               
                 25 
                 Lemon 
                 FEMALE 
                 4.556 
                 5.959 
               
               
                   
                   
                 MALE 
                 4.179 
                 5.210 
               
               
                 26 
                 Barley 
                 FEMALE 
                 35.136 
                 46.859 
               
               
                   
                   
                 MALE 
                 36.197 
                 45.928 
               
               
                 27 
                 Oat 
                 FEMALE 
                 33.278 
                 44.414 
               
               
                   
                   
                 MALE 
                 55.311 
                 72.680 
               
               
                 28 
                 Oyster 
                 FEMALE 
                 86.278 
                 114.96 
               
               
                   
                   
                 MALE 
                 82.294 
                 119.88 
               
               
                 29 
                 Mustard 
                 FEMALE 
                 17.479 
                 19.400 
               
               
                   
                   
                 MALE 
                 16.227 
                 20.884 
               
               
                 30 
                 Rye 
                 FEMALE 
                 8.475 
                 12.141 
               
               
                   
                   
                 MALE 
                 8.360 
                 10.635 
               
               
                 31 
                 Peach 
                 FEMALE 
                 17.987 
                 26.936 
               
               
                   
                   
                 MALE 
                 17.616 
                 26.755 
               
               
                 32 
                 Chili_Pepper 
                 FEMALE 
                 16.296 
                 25.191 
               
               
                   
                   
                 MALE 
                 14.040 
                 21.503 
               
               
                 33 
                 Spinach 
                 FEMALE 
                 37.895 
                 48.052 
               
               
                   
                   
                 MALE 
                 24.957 
                 28.650 
               
               
                 34 
                 Peanut 
                 FEMALE 
                 11.190 
                 16.279 
               
               
                   
                   
                 MALE 
                 6.920 
                 9.159 
               
               
                 35 
                 Avocado 
                 FEMALE 
                 5.397 
                 7.247 
               
               
                   
                   
                 MALE 
                 4.483 
                 5.566 
               
               
                 36 
                 Shrimp 
                 FEMALE 
                 81.870 
                 98.743 
               
               
                   
                   
                 MALE 
                 69.799 
                 101.18 
               
               
                 37 
                 Pineapple 
                 FEMALE 
                 65.230 
                 122.14 
               
               
                   
                   
                 MALE 
                 65.661 
                 106.68 
               
               
                 38 
                 Cola_Nut 
                 FEMALE 
                 48.288 
                 53.448 
               
               
                   
                   
                 MALE 
                 59.969 
                 72.288 
               
               
                 39 
                 Rice 
                 FEMALE 
                 40.837 
                 58.139 
               
               
                   
                   
                 MALE 
                 52.100 
                 63.388 
               
               
                 40 
                 Cabbage 
                 FEMALE 
                 18.343 
                 28.722 
               
               
                   
                   
                 MALE 
                 9.730 
                 18.345 
               
               
                 41 
                 Butter 
                 FEMALE 
                 47.381 
                 71.040 
               
               
                   
                   
                 MALE 
                 44.178 
                 58.044 
               
               
                 42 
                 Eggplant 
                 FEMALE 
                 12.557 
                 18.816 
               
               
                   
                   
                 MALE 
                 9.359 
                 14.446 
               
               
                 43 
                 Apple 
                 FEMALE 
                 9.017 
                 11.837 
               
               
                   
                   
                 MALE 
                 8.631 
                 10.597 
               
               
                 44 
                 Egg 
                 FEMALE 
                 144.38 
                 280.18 
               
               
                   
                   
                 MALE 
                 106.91 
                 197.02 
               
               
                 45 
                 Wheat 
                 FEMALE 
                 30.663 
                 56.824 
               
               
                   
                   
                 MALE 
                 27.355 
                 37.901 
               
               
                 46 
                 Cottage_Ch —   
                 FEMALE 
                 200.80 
                 287.02 
               
               
                   
                   
                 MALE 
                 220.78 
                 348.31 
               
               
                 47 
                 Sole 
                 FEMALE 
                 9.355 
                 14.730 
               
               
                   
                   
                 MALE 
                 7.466 
                 9.176 
               
               
                 48 
                 Cashew 
                 FEMALE 
                 23.551 
                 44.896 
               
               
                   
                   
                 MALE 
                 17.371 
                 32.259 
               
               
                 49 
                 Olive 
                 FEMALE 
                 48.012 
                 55.113 
               
               
                   
                   
                 MALE 
                 42.612 
                 61.277 
               
               
                 50 
                 Parsley 
                 FEMALE 
                 11.123 
                 19.965 
               
               
                   
                   
                 MALE 
                 8.545 
                 17.265 
               
               
                 51 
                 Corn 
                 FEMALE 
                 20.036 
                 31.057 
               
               
                   
                   
                 MALE 
                 19.953 
                 30.126 
               
               
                 52 
                 Honey 
                 FEMALE 
                 16.276 
                 17.419 
               
               
                   
                   
                 MALE 
                 19.199 
                 24.877 
               
               
                 53 
                 Chocolate 
                 FEMALE 
                 23.555 
                 25.869 
               
               
                   
                   
                 MALE 
                 32.644 
                 37.625 
               
               
                 54 
                 Cow_Milk 
                 FEMALE 
                 199.39 
                 248.98 
               
               
                   
                   
                 MALE 
                 181.23 
                 316.72 
               
               
                 55 
                 Potato 
                 FEMALE 
                 20.155 
                 25.293 
               
               
                   
                   
                 MALE 
                 21.203 
                 24.281 
               
               
                 56 
                 Onion 
                 FEMALE 
                 20.204 
                 37.487 
               
               
                   
                   
                 MALE 
                 25.719 
                 33.230 
               
               
                 57 
                 Tea 
                 FEMALE 
                 46.116 
                 53.257 
               
               
                   
                   
                 MALE 
                 49.893 
                 56.701 
               
               
                 58 
                 Tobacco 
                 FEMALE 
                 57.943 
                 64.379 
               
               
                   
                   
                 MALE 
                 73.610 
                 101.38 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                   
                 TABLE 5A 
               
               
                   
                   
               
               
                   
                   
                 # of Positive 
               
               
                   
                   
                 Results Based on 
               
               
                   
                 Sample ID 
                 90th Percentile 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
            
               
                 ULCERATIVE COLITIS POPULATION 
               
            
           
           
               
               
               
            
               
                   
                 160905AAC0012 
                 13 
               
               
                   
                 160905AAC0013 
                 14 
               
               
                   
                 160905AAC0008 
                 37 
               
               
                   
                 160905AAC0001 
                 26 
               
               
                   
                 160905AAC0003 
                 15 
               
               
                   
                 BRH1274374 
                 4 
               
               
                   
                 BRH1274378 
                 9 
               
               
                   
                 BRH1274380 
                 10 
               
               
                   
                 BRH1272208 
                 4 
               
               
                   
                 BRH1272209 
                 36 
               
               
                   
                 BRH1272210 
                 6 
               
               
                   
                 BRH1272213 
                 43 
               
               
                   
                 BRH1272218 
                 7 
               
               
                   
                 BRH1272220 
                 28 
               
               
                   
                 BRH1272223 
                 25 
               
               
                   
                 BRH1272224 
                 7 
               
               
                   
                 BRH1272225 
                 7 
               
               
                   
                 BRH1272226 
                 40 
               
               
                   
                 BRH1272227 
                 5 
               
               
                   
                 BRH1265975 
                 33 
               
               
                   
                 BRH1265977 
                 7 
               
               
                   
                 BRH1265978 
                 9 
               
               
                   
                 BRH1265979 
                 33 
               
               
                   
                 BRH1265980 
                 3 
               
               
                   
                 BRH1265982 
                 23 
               
               
                   
                 BRH1265983 
                 11 
               
               
                   
                 BRH1265985 
                 8 
               
               
                   
                 BRH1265987 
                 22 
               
               
                   
                 BRH1265988 
                 0 
               
               
                   
                 BRH1265992 
                 1 
               
               
                   
                 BRH1265995 
                 26 
               
               
                   
                 BRH1269735 
                 29 
               
               
                   
                 BRH1269736 
                 13 
               
               
                   
                 BRH1269737 
                 18 
               
               
                   
                 BRH1269739 
                 18 
               
               
                   
                 BRH1269741 
                 25 
               
               
                   
                 BRH1269746 
                 4 
               
               
                   
                 BRH1269747 
                 19 
               
               
                   
                 BRH1269748 
                 2 
               
               
                   
                 BRH1269752 
                 1 
               
               
                   
                 BRH1269753 
                 2 
               
               
                   
                 BRH1269755 
                 19 
               
               
                   
                 BRH1269756 
                 6 
               
               
                   
                 BRH1269758 
                 24 
               
               
                   
                 DLS16-69619 
                 1 
               
               
                   
                 DLS16-32252 
                 13 
               
               
                   
                 160905AAC0014 
                 37 
               
               
                   
                 160905AAC0015 
                 9 
               
               
                   
                 160905AAC0016 
                 5 
               
               
                   
                 160905AAC0005 
                 8 
               
               
                   
                 160905AAC0006 
                 4 
               
               
                   
                 160905AAC0007 
                 53 
               
               
                   
                 160905AAC0009 
                 24 
               
               
                   
                 160905AAC0010 
                 2 
               
               
                   
                 160905AAC0011 
                 1 
               
               
                   
                 160905AAC0002 
                 5 
               
               
                   
                 160905AAC0004 
                 2 
               
               
                   
                 BRH1274375 
                 4 
               
               
                   
                 BRH1274376 
                 6 
               
               
                   
                 BRH1274377 
                 6 
               
               
                   
                 BRH1274379 
                 2 
               
               
                   
                 BRH1274381 
                 15 
               
               
                   
                 BRH1274382 
                 2 
               
               
                   
                 BRH1274383 
                 14 
               
               
                   
                 BRH1272211 
                 6 
               
               
                   
                 BRH1272212 
                 3 
               
               
                   
                 BRH1272214 
                 11 
               
               
                   
                 BRH1272215 
                 8 
               
               
                   
                 BRH1272216 
                 2 
               
               
                   
                 BRH1272217 
                 8 
               
               
                   
                 BRH1272219 
                 26 
               
               
                   
                 BRH1272221 
                 0 
               
               
                   
                 BRH1272222 
                 50 
               
               
                   
                 BRH1272228 
                 6 
               
               
                   
                 BRH1265976 
                 1 
               
               
                   
                 BRH1265981 
                 1 
               
               
                   
                 BRH1265984 
                 10 
               
               
                   
                 BRH1265986 
                 16 
               
               
                   
                 BRH1265989 
                 37 
               
               
                   
                 BRH1265990 
                 1 
               
               
                   
                 BRH1265991 
                 8 
               
               
                   
                 BRH1265993 
                 4 
               
               
                   
                 BRH1265994 
                 8 
               
               
                   
                 BRH1265996 
                 20 
               
               
                   
                 BRH1265997 
                 14 
               
               
                   
                 BRH1265998 
                 3 
               
               
                   
                 BRH1265999 
                 9 
               
               
                   
                 BRH1266000 
                 12 
               
               
                   
                 BRH1269734 
                 3 
               
               
                   
                 BRH1269738 
                 2 
               
               
                   
                 BRH1269740 
                 27 
               
               
                   
                 BRH1269742 
                 13 
               
               
                   
                 BRH1269743 
                 11 
               
               
                   
                 BRH1269744 
                 4 
               
               
                   
                 BRH1269745 
                 19 
               
               
                   
                 BRH1269749 
                 0 
               
               
                   
                 BRH1269750 
                 23 
               
               
                   
                 BRH1269751 
                 8 
               
               
                   
                 BRH1269754 
                 5 
               
               
                   
                 BRH1269757 
                 3 
               
               
                   
                 DLS16-32288 
                 8 
               
               
                   
                 DLS16-68885 
                 13 
               
               
                   
                 DLS16-69258 
                 3 
               
               
                   
                 No of 
                 103 
               
               
                   
                 Observations 
               
               
                   
                 Average Number 
                 12.7 
               
               
                   
                 Median Number 
                 8 
               
               
                   
                 # of Patients w/ 0 
                 3 
               
               
                   
                 Pos Results 
               
               
                   
                 % Subjects w/ 0 
                 2.9 
               
               
                   
                 pos results 
               
            
           
           
               
            
               
                 NON-ULCERATIVE COLITIS 
               
               
                 POPULATION 
               
            
           
           
               
               
               
            
               
                   
                 BRH1244900 
                 3 
               
               
                   
                 BRH1244901 
                 14 
               
               
                   
                 BRH1244902 
                 2 
               
               
                   
                 BRH1244903 
                 1 
               
               
                   
                 BRH1244904 
                 1 
               
               
                   
                 BRH1244905 
                 1 
               
               
                   
                 BRH1244906 
                 15 
               
               
                   
                 BRH1244907 
                 0 
               
               
                   
                 BRH1244908 
                 5 
               
               
                   
                 BRH1244909 
                 7 
               
               
                   
                 BRH1244910 
                 6 
               
               
                   
                 BRH1244911 
                 2 
               
               
                   
                 BRH1244912 
                 4 
               
               
                   
                 BRH1244913 
                 1 
               
               
                   
                 BRH1244914 
                 11 
               
               
                   
                 BRH1244915 
                 1 
               
               
                   
                 BRH1244916 
                 8 
               
               
                   
                 BRH1244917 
                 24 
               
               
                   
                 BRH1244918 
                 4 
               
               
                   
                 BRH1244919 
                 0 
               
               
                   
                 BRH1244920 
                 5 
               
               
                   
                 BRH1244921 
                 4 
               
               
                   
                 BRH1244922 
                 33 
               
               
                   
                 BRH1244923 
                 3 
               
               
                   
                 BRH1244924 
                 1 
               
               
                   
                 BRH1244925 
                 5 
               
               
                   
                 BRH1244926 
                 19 
               
               
                   
                 BRH1244927 
                 3 
               
               
                   
                 BRH1244928 
                 9 
               
               
                   
                 BRH1244929 
                 6 
               
               
                   
                 BRH1244930 
                 1 
               
               
                   
                 BRH1244931 
                 0 
               
               
                   
                 BRH1244932 
                 15 
               
               
                   
                 BRH1244933 
                 8 
               
               
                   
                 BRH1244934 
                 13 
               
               
                   
                 BRH1244935 
                 21 
               
               
                   
                 BRH1244936 
                 5 
               
               
                   
                 BRH1244937 
                 7 
               
               
                   
                 BRH1244938 
                 14 
               
               
                   
                 BRH1244939 
                 6 
               
               
                   
                 BRH1244940 
                 2 
               
               
                   
                 BRH1244941 
                 1 
               
               
                   
                 BRH1244942 
                 10 
               
               
                   
                 BRH1244943 
                 2 
               
               
                   
                 BRH1244944 
                 38 
               
               
                   
                 BRH1244945 
                 0 
               
               
                   
                 BRH1244946 
                 12 
               
               
                   
                 BRH1244947 
                 8 
               
               
                   
                 BRH1244948 
                 6 
               
               
                   
                 BRH1244949 
                 4 
               
               
                   
                 BRH1244950 
                 2 
               
               
                   
                 BRH1244951 
                 0 
               
               
                   
                 BRH1244952 
                 2 
               
               
                   
                 BRH1244953 
                 5 
               
               
                   
                 BRH1244954 
                 0 
               
               
                   
                 BRH1244955 
                 0 
               
               
                   
                 BRH1244956 
                 43 
               
               
                   
                 BRH1244957 
                 4 
               
               
                   
                 BRH1244958 
                 4 
               
               
                   
                 BRH1244959 
                 1 
               
               
                   
                 BRH1244960 
                 1 
               
               
                   
                 BRH1244961 
                 1 
               
               
                   
                 BRH1244962 
                 2 
               
               
                   
                 BRH1244963 
                 4 
               
               
                   
                 BRH1244964 
                 8 
               
               
                   
                 BRH1244965 
                 5 
               
               
                   
                 BRH1244966 
                 2 
               
               
                   
                 BRH1244967 
                 3 
               
               
                   
                 BRH1244968 
                 0 
               
               
                   
                 BRH1244969 
                 2 
               
               
                   
                 BRH1244970 
                 9 
               
               
                   
                 BRH1244971 
                 11 
               
               
                   
                 BRH1244972 
                 1 
               
               
                   
                 BRH1244973 
                 7 
               
               
                   
                 BRH1244974 
                 1 
               
               
                   
                 BRH1244975 
                 0 
               
               
                   
                 BRH1244976 
                 4 
               
               
                   
                 BRH1244977 
                 0 
               
               
                   
                 BRH1244978 
                 0 
               
               
                   
                 BRH1244979 
                 0 
               
               
                   
                 BRH1244980 
                 0 
               
               
                   
                 BRH1244981 
                 2 
               
               
                   
                 BRH1244982 
                 0 
               
               
                   
                 BRH1244983 
                 2 
               
               
                   
                 BRH1244984 
                 3 
               
               
                   
                 BRH1244985 
                 5 
               
               
                   
                 BRH1244986 
                 0 
               
               
                   
                 BRH1244987 
                 1 
               
               
                   
                 BRH1244988 
                 11 
               
               
                   
                 BRH1244989 
                 3 
               
               
                   
                 BRH1244990 
                 2 
               
               
                   
                 BRH1244991 
                 0 
               
               
                   
                 BRH1244992 
                 1 
               
               
                   
                 BRH1267320 
                 0 
               
               
                   
                 BRH1267321 
                 15 
               
               
                   
                 BRH1267322 
                 9 
               
               
                   
                 BRH1267323 
                 0 
               
               
                   
                 BRH1244993 
                 0 
               
               
                   
                 BRH1244994 
                 0 
               
               
                   
                 BRH1244995 
                 0 
               
               
                   
                 BRH1244996 
                 2 
               
               
                   
                 BRH1244997 
                 2 
               
               
                   
                 BRH1244998 
                 5 
               
               
                   
                 BRH1244999 
                 2 
               
               
                   
                 BRH1245000 
                 8 
               
               
                   
                 BRH1245001 
                 3 
               
               
                   
                 BRH1245002 
                 4 
               
               
                   
                 BRH1245003 
                 5 
               
               
                   
                 BRH1245004 
                 1 
               
               
                   
                 BRH1245005 
                 1 
               
               
                   
                 BRH1245006 
                 0 
               
               
                   
                 BRH1245007 
                 0 
               
               
                   
                 BRH1245008 
                 16 
               
               
                   
                 BRH1245009 
                 4 
               
               
                   
                 BRH1245010 
                 11 
               
               
                   
                 BRH1245011 
                 14 
               
               
                   
                 BRH1245012 
                 1 
               
               
                   
                 BRH1245013 
                 26 
               
               
                   
                 BRH1245014 
                 0 
               
               
                   
                 BRH1245015 
                 2 
               
               
                   
                 BRH1245016 
                 17 
               
               
                   
                 BRH1245017 
                 0 
               
               
                   
                 BRH1245018 
                 0 
               
               
                   
                 BRH1245019 
                 6 
               
               
                   
                 BRH1245020 
                 19 
               
               
                   
                 BRH1245021 
                 1 
               
               
                   
                 BRH1245022 
                 26 
               
               
                   
                 BRH1245023 
                 3 
               
               
                   
                 BRH1245024 
                 2 
               
               
                   
                 BRH1245025 
                 11 
               
               
                   
                 BRH1245026 
                 8 
               
               
                   
                 BRH1245027 
                 20 
               
               
                   
                 BRH1245029 
                 2 
               
               
                   
                 BRH1245030 
                 5 
               
               
                   
                 BRH1245031 
                 3 
               
               
                   
                 BRH1245032 
                 0 
               
               
                   
                 BRH1245033 
                 4 
               
               
                   
                 BRH1245034 
                 6 
               
               
                   
                 BRH1245035 
                 1 
               
               
                   
                 BRH1245036 
                 17 
               
               
                   
                 BRH1245037 
                 0 
               
               
                   
                 BRH1245038 
                 4 
               
               
                   
                 BRH1245039 
                 9 
               
               
                   
                 BRH1245040 
                 4 
               
               
                   
                 BRH1245041 
                 2 
               
               
                   
                 BRH1267327 
                 5 
               
               
                   
                 BRH1267329 
                 3 
               
               
                   
                 BRH1267330 
                 2 
               
               
                   
                 BRH1267331 
                 2 
               
               
                   
                 BRH1267333 
                 2 
               
               
                   
                 BRH1267334 
                 26 
               
               
                   
                 BRH1267335 
                 11 
               
               
                   
                 BRH1267337 
                 6 
               
               
                   
                 BRH1267338 
                 0 
               
               
                   
                 BRH1267339 
                 10 
               
               
                   
                 BRH1267340 
                 18 
               
               
                   
                 BRH1267341 
                 0 
               
               
                   
                 BRH1267342 
                 2 
               
               
                   
                 BRH1267343 
                 9 
               
               
                   
                 BRH1267345 
                 0 
               
               
                   
                 BRH1267346 
                 1 
               
               
                   
                 BRH1267347 
                 1 
               
               
                   
                 BRH1267349 
                 2 
               
               
                   
                 No of 
                 163 
               
               
                   
                 Observations 
               
               
                   
                 Average Number 
                 5.7 
               
               
                   
                 Median Number 
                 3 
               
               
                   
                 # of Patients w/ 0 
                 31 
               
               
                   
                 Pos Results 
               
               
                   
                 % Subjects w/ 0 
                 19.0 
               
               
                   
                 pos results 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 5B 
               
               
                   
               
               
                   
                   
                 # of Positive Results 
               
               
                   
                 Sample ID 
                 Based on 95th Percentile 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
            
               
                 ULCERATIVE COLITIS POPULATION 
               
            
           
           
               
               
               
            
               
                   
                 160905AAC0012 
                 7 
               
               
                   
                 160905AAC0013 
                 4 
               
               
                   
                 160905AAC0008 
                 31 
               
               
                   
                 160905AAC0001 
                 22 
               
               
                   
                 160905AAC0003 
                 6 
               
               
                   
                 BRH1274374 
                 4 
               
               
                   
                 BRH1274378 
                 7 
               
               
                   
                 BRH1274380 
                 2 
               
               
                   
                 BRH1272208 
                 1 
               
               
                   
                 BRH1272209 
                 23 
               
               
                   
                 BRH1272210 
                 3 
               
               
                   
                 BRH1272213 
                 28 
               
               
                   
                 BRH1272218 
                 3 
               
               
                   
                 BRH1272220 
                 17 
               
               
                   
                 BRH1272223 
                 17 
               
               
                   
                 BRH1272224 
                 5 
               
               
                   
                 BRH1272225 
                 4 
               
               
                   
                 BRH1272226 
                 26 
               
               
                   
                 BRH1272227 
                 4 
               
               
                   
                 BRH1265975 
                 25 
               
               
                   
                 BRH1265977 
                 3 
               
               
                   
                 BRH1265978 
                 4 
               
               
                   
                 BRH1265979 
                 16 
               
               
                   
                 BRH1265980 
                 0 
               
               
                   
                 BRH1265982 
                 9 
               
               
                   
                 BRH1265983 
                 5 
               
               
                   
                 BRH1265985 
                 6 
               
               
                   
                 BRH1265987 
                 6 
               
               
                   
                 BRH1265988 
                 0 
               
               
                   
                 BRH1265992 
                 0 
               
               
                   
                 BRH1265995 
                 22 
               
               
                   
                 BRH1269735 
                 19 
               
               
                   
                 BRH1269736 
                 11 
               
               
                   
                 BRH1269737 
                 8 
               
               
                   
                 BRH1269739 
                 10 
               
               
                   
                 BRH1269741 
                 16 
               
               
                   
                 BRH1269746 
                 1 
               
               
                   
                 BRH1269747 
                 8 
               
               
                   
                 BRH1269748 
                 0 
               
               
                   
                 BRH1269752 
                 0 
               
               
                   
                 BRH1269753 
                 1 
               
               
                   
                 BRH1269755 
                 15 
               
               
                   
                 BRH1269756 
                 3 
               
               
                   
                 BRH1269758 
                 11 
               
               
                   
                 DLS16-69619 
                 1 
               
               
                   
                 DLS16-32252 
                 9 
               
               
                   
                 160905AAC0014 
                 30 
               
               
                   
                 160905AAC0015 
                 6 
               
               
                   
                 160905AAC0016 
                 4 
               
               
                   
                 160905AAC0005 
                 5 
               
               
                   
                 160905AAC0006 
                 2 
               
               
                   
                 160905AAC0007 
                 47 
               
               
                   
                 160905AAC0009 
                 15 
               
               
                   
                 160905AAC0010 
                 1 
               
               
                   
                 160905AAC0011 
                 0 
               
               
                   
                 160905AAC0002 
                 2 
               
               
                   
                 160905AAC0004 
                 0 
               
               
                   
                 BRH1274375 
                 2 
               
               
                   
                 BRH1274376 
                 4 
               
               
                   
                 BRH1274377 
                 3 
               
               
                   
                 BRH1274379 
                 1 
               
               
                   
                 BRH1274381 
                 8 
               
               
                   
                 BRH1274382 
                 1 
               
               
                   
                 BRH1274383 
                 9 
               
               
                   
                 BRH1272211 
                 4 
               
               
                   
                 BRH1272212 
                 1 
               
               
                   
                 BRH1272214 
                 7 
               
               
                   
                 BRH1272215 
                 6 
               
               
                   
                 BRH1272216 
                 1 
               
               
                   
                 BRH1272217 
                 6 
               
               
                   
                 BRH1272219 
                 17 
               
               
                   
                 BRH1272221 
                 0 
               
               
                   
                 BRH1272222 
                 46 
               
               
                   
                 BRH1272228 
                 1 
               
               
                   
                 BRH1265976 
                 1 
               
               
                   
                 BRH1265981 
                 1 
               
               
                   
                 BRH1265984 
                 5 
               
               
                   
                 BRH1265986 
                 9 
               
               
                   
                 BRH1265989 
                 23 
               
               
                   
                 BRH1265990 
                 0 
               
               
                   
                 BRH1265991 
                 5 
               
               
                   
                 BRH1265993 
                 1 
               
               
                   
                 BRH1265994 
                 3 
               
               
                   
                 BRH1265996 
                 15 
               
               
                   
                 BRH1265997 
                 11 
               
               
                   
                 BRH1265998 
                 0 
               
               
                   
                 BRH1265999 
                 7 
               
               
                   
                 BRH1266000 
                 7 
               
               
                   
                 BRH1269734 
                 0 
               
               
                   
                 BRH1269738 
                 2 
               
               
                   
                 BRH1269740 
                 19 
               
               
                   
                 BRH1269742 
                 7 
               
               
                   
                 BRH1269743 
                 8 
               
               
                   
                 BRH1269744 
                 1 
               
               
                   
                 BRH1269745 
                 15 
               
               
                   
                 BRH1269749 
                 0 
               
               
                   
                 BRH1269750 
                 18 
               
               
                   
                 BRH1269751 
                 6 
               
               
                   
                 BRH1269754 
                 1 
               
               
                   
                 BRH1269757 
                 3 
               
               
                   
                 DLS16-32288 
                 2 
               
               
                   
                 DLS16-68885 
                 11 
               
               
                   
                 DLS16-69258 
                 3 
               
               
                   
                 No of Observations 
                 103 
               
               
                   
                 Average Number 
                 8.1 
               
               
                   
                 Median Number 
                 5 
               
               
                   
                 # of Patients w/0 Pos Results 
                 12 
               
               
                   
                 % Subjects w/0 pos results 
                 11.7 
               
            
           
           
               
            
               
                 NON-ULCERATIVE COLITIS POPULATION 
               
            
           
           
               
               
               
            
               
                   
                 BRH1244900 
                 2 
               
               
                   
                 BRH1244901 
                 5 
               
               
                   
                 BRH1244902 
                 2 
               
               
                   
                 BRH1244903 
                 0 
               
               
                   
                 BRH1244904 
                 1 
               
               
                   
                 BRH1244905 
                 0 
               
               
                   
                 BRH1244906 
                 5 
               
               
                   
                 BRH1244907 
                 0 
               
               
                   
                 BRH1244908 
                 2 
               
               
                   
                 BRH1244909 
                 5 
               
               
                   
                 BRH1244910 
                 2 
               
               
                   
                 BRH1244911 
                 0 
               
               
                   
                 BRH1244912 
                 1 
               
               
                   
                 BRH1244913 
                 0 
               
               
                   
                 BRH1244914 
                 7 
               
               
                   
                 BRH1244915 
                 0 
               
               
                   
                 BRH1244916 
                 4 
               
               
                   
                 BRH1244917 
                 16 
               
               
                   
                 BRH1244918 
                 1 
               
               
                   
                 BRH1244919 
                 0 
               
               
                   
                 BRH1244920 
                 4 
               
               
                   
                 BRH1244921 
                 2 
               
               
                   
                 BRH1244922 
                 17 
               
               
                   
                 BRH1244923 
                 2 
               
               
                   
                 BRH1244924 
                 1 
               
               
                   
                 BRH1244925 
                 1 
               
               
                   
                 BRH1244926 
                 13 
               
               
                   
                 BRH1244927 
                 2 
               
               
                   
                 BRH1244928 
                 3 
               
               
                   
                 BRH1244929 
                 2 
               
               
                   
                 BRH1244930 
                 1 
               
               
                   
                 BRH1244931 
                 0 
               
               
                   
                 BRH1244932 
                 7 
               
               
                   
                 BRH1244933 
                 2 
               
               
                   
                 BRH1244934 
                 5 
               
               
                   
                 BRH1244935 
                 11 
               
               
                   
                 BRH1244936 
                 3 
               
               
                   
                 BRH1244937 
                 3 
               
               
                   
                 BRH1244938 
                 5 
               
               
                   
                 BRH1244939 
                 2 
               
               
                   
                 BRH1244940 
                 1 
               
               
                   
                 BRH1244941 
                 1 
               
               
                   
                 BRH1244942 
                 5 
               
               
                   
                 BRH1244943 
                 1 
               
               
                   
                 BRH1244944 
                 14 
               
               
                   
                 BRH1244945 
                 0 
               
               
                   
                 BRH1244946 
                 4 
               
               
                   
                 BRH1244947 
                 3 
               
               
                   
                 BRH1244948 
                 0 
               
               
                   
                 BRH1244949 
                 3 
               
               
                   
                 BRH1244950 
                 1 
               
               
                   
                 BRH1244951 
                 0 
               
               
                   
                 BRH1244952 
                 0 
               
               
                   
                 BRH1244953 
                 1 
               
               
                   
                 BRH1244954 
                 0 
               
               
                   
                 BRH1244955 
                 0 
               
               
                   
                 BRH1244956 
                 31 
               
               
                   
                 BRH1244957 
                 3 
               
               
                   
                 BRH1244958 
                 1 
               
               
                   
                 BRH1244959 
                 0 
               
               
                   
                 BRH1244960 
                 0 
               
               
                   
                 BRH1244961 
                 1 
               
               
                   
                 BRH1244962 
                 1 
               
               
                   
                 BRH1244963 
                 1 
               
               
                   
                 BRH1244964 
                 5 
               
               
                   
                 BRH1244965 
                 2 
               
               
                   
                 BRH1244966 
                 1 
               
               
                   
                 BRH1244967 
                 1 
               
               
                   
                 BRH1244968 
                 0 
               
               
                   
                 BRH1244969 
                 1 
               
               
                   
                 BRH1244970 
                 3 
               
               
                   
                 BRH1244971 
                 4 
               
               
                   
                 BRH1244972 
                 1 
               
               
                   
                 BRH1244973 
                 3 
               
               
                   
                 BRH1244974 
                 1 
               
               
                   
                 BRH1244975 
                 0 
               
               
                   
                 BRH1244976 
                 2 
               
               
                   
                 BRH1244977 
                 0 
               
               
                   
                 BRH1244978 
                 0 
               
               
                   
                 BRH1244979 
                 0 
               
               
                   
                 BRH1244980 
                 0 
               
               
                   
                 BRH1244981 
                 1 
               
               
                   
                 BRH1244982 
                 0 
               
               
                   
                 BRH1244983 
                 2 
               
               
                   
                 BRH1244984 
                 1 
               
               
                   
                 BRH1244985 
                 2 
               
               
                   
                 BRH1244986 
                 0 
               
               
                   
                 BRH1244987 
                 0 
               
               
                   
                 BRH1244988 
                 8 
               
               
                   
                 BRH1244989 
                 1 
               
               
                   
                 BRH1244990 
                 1 
               
               
                   
                 BRH1244991 
                 1 
               
               
                   
                 BRH1244992 
                 0 
               
               
                   
                 BRH1267320 
                 0 
               
               
                   
                 BRH1267321 
                 12 
               
               
                   
                 BRH1267322 
                 3 
               
               
                   
                 BRH1267323 
                 0 
               
               
                   
                 BRH1244993 
                 0 
               
               
                   
                 BRH1244994 
                 0 
               
               
                   
                 BRH1244995 
                 0 
               
               
                   
                 BRH1244996 
                 1 
               
               
                   
                 BRH1244997 
                 1 
               
               
                   
                 BRH1244998 
                 4 
               
               
                   
                 BRH1244999 
                 1 
               
               
                   
                 BRH1245000 
                 3 
               
               
                   
                 BRH1245001 
                 0 
               
               
                   
                 BRH1245002 
                 1 
               
               
                   
                 BRH1245003 
                 1 
               
               
                   
                 BRH1245004 
                 0 
               
               
                   
                 BRH1245005 
                 1 
               
               
                   
                 BRH1245006 
                 0 
               
               
                   
                 BRH1245007 
                 0 
               
               
                   
                 BRH1245008 
                 10 
               
               
                   
                 BRH1245009 
                 3 
               
               
                   
                 BRH1245010 
                 3 
               
               
                   
                 BRH1245011 
                 10 
               
               
                   
                 BRH1245012 
                 0 
               
               
                   
                 BRH1245013 
                 10 
               
               
                   
                 BRH1245014 
                 0 
               
               
                   
                 BRH1245015 
                 2 
               
               
                   
                 BRH1245016 
                 5 
               
               
                   
                 BRH1245017 
                 0 
               
               
                   
                 BRH1245018 
                 0 
               
               
                   
                 BRH1245019 
                 5 
               
               
                   
                 BRH1245020 
                 13 
               
               
                   
                 BRH1245021 
                 0 
               
               
                   
                 BRH1245022 
                 15 
               
               
                   
                 BRH1245023 
                 1 
               
               
                   
                 BRH1245024 
                 1 
               
               
                   
                 BRH1245025 
                 6 
               
               
                   
                 BRH1245026 
                 5 
               
               
                   
                 BRH1245027 
                 13 
               
               
                   
                 BRH1245029 
                 1 
               
               
                   
                 BRH1245030 
                 1 
               
               
                   
                 BRH1245031 
                 3 
               
               
                   
                 BRH1245032 
                 0 
               
               
                   
                 BRH1245033 
                 1 
               
               
                   
                 BRH1245034 
                 2 
               
               
                   
                 BRH1245035 
                 0 
               
               
                   
                 BRH1245036 
                 6 
               
               
                   
                 BRH1245037 
                 0 
               
               
                   
                 BRH1245038 
                 4 
               
               
                   
                 BRH1245039 
                 6 
               
               
                   
                 BRH1245040 
                 0 
               
               
                   
                 BRH1245041 
                 0 
               
               
                   
                 BRH1267327 
                 3 
               
               
                   
                 BRH1267329 
                 2 
               
               
                   
                 BRH1267330 
                 2 
               
               
                   
                 BRH1267331 
                 1 
               
               
                   
                 BRH1267333 
                 1 
               
               
                   
                 BRH1267334 
                 13 
               
               
                   
                 BRH1267335 
                 7 
               
               
                   
                 BRH1267337 
                 4 
               
               
                   
                 BRH1267338 
                 0 
               
               
                   
                 BRH1267339 
                 3 
               
               
                   
                 BRH1267340 
                 14 
               
               
                   
                 BRH1267341 
                 0 
               
               
                   
                 BRH1267342 
                 1 
               
               
                   
                 BRH1267343 
                 6 
               
               
                   
                 BRH1267345 
                 0 
               
               
                   
                 BRH1267346 
                 0 
               
               
                   
                 BRH1267347 
                 0 
               
               
                   
                 BRH1267349 
                 2 
               
               
                   
                 No of Observations 
                 163 
               
               
                   
                 Average Number 
                 2.9 
               
               
                   
                 Median Number 
                 1 
               
               
                   
                 # of Patients w/0 Pos Results 
                 50 
               
               
                   
                 % Subjects w/0 pos results 
                 30.7 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 6A 
               
               
                   
               
               
                 Summary statistics 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                   
                 Ulcerative_Colitis_90th_percentile 
               
               
                 Variable 
                 Ulcerative Colitis 90th percentile 
               
               
                   
               
               
                 Sample size 
                 103     
               
               
                 Lowest value 
                 
                   0.0000 
                 
               
               
                 Highest value 
                   53.0000   
               
               
                 Arithmetic mean 
                 12.7282  
               
               
                 95% CI for the mean 
                 10.3973 to 15.0590 
               
               
                 Median 
                 8.0000 
               
               
                 95% CI for the median 
                  7.0000 to 11.0000 
               
               
                 Variance 
                 142.2391  
               
               
                 Standard deviation 
                 11.9264  
               
            
           
           
               
               
               
            
               
                 Relative standard deviation 
                 0.9370 
                 (93.70%) 
               
            
           
           
               
               
            
               
                 Standard error of the mean 
                 1.1751 
               
            
           
           
               
               
               
            
               
                 Coefficient of Skewness 
                 1.3143 
                 (P &lt; 0.0001) 
               
               
                 Coefficient of Kurtosis 
                 1.2515 
                 (P = 0.0379) 
               
            
           
           
               
               
            
               
                 D&#39;Agostino-Pearson test 
                 reject Normality 
               
               
                 for Normal distribution 
                 (P &lt; 0.0001) 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Percentiles 
                   
                 95% Confidence interval 
               
               
                   
               
               
                 2.5 
                 0.07500 
                   
               
               
                 5 
                 1.0000 
                 0.0000 to 1.3540 
               
               
                 10 
                 1.8000 
                 1.0000 to 2.0000 
               
               
                 25 
                 4.0000 
                 2.0000 to 5.0730 
               
               
                 75 
                 19.0000 
                 13.9270 to 25.0000 
               
               
                 90 
                 29.8000 
                 25.0000 to 37.0000 
               
               
                 95 
                 37.0000 
                 31.5842 to 50.5298 
               
               
                 97.5 
                 42.7750 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 6B 
               
               
                   
               
               
                 Summary statistics 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                   
                 Ulcerative_Colitis_95th_percentile 
               
               
                 Variable 
                 Ulcerative Colitis 95th percentile 
               
               
                   
               
               
                 Sample size 
                 103     
               
               
                 Lowest value 
                 
                   0.0000 
                 
               
               
                 Highest value 
                   47.0000   
               
               
                 Arithmetic mean 
                 8.1165 
               
               
                 95% CI for the mean 
                 6.2898 to 9.9432 
               
               
                 Median 
                 5.0000 
               
               
                 95% CI for the median 
                 4.0000 to 6.9228 
               
               
                 Variance 
                 87.3588  
               
               
                 Standard deviation 
                 9.3466 
               
            
           
           
               
               
               
            
               
                 Relative standard deviation 
                 1.1516 
                 (115.16%) 
               
            
           
           
               
               
            
               
                 Standard error of the mean 
                 0.9209 
               
            
           
           
               
               
               
            
               
                 Coefficient of Skewness 
                 1.9463 
                 (P &lt; 0.0001) 
               
               
                 Coefficient of Kurtosis 
                 4.4608 
                 (P &lt; 0.0001) 
               
            
           
           
               
               
            
               
                 D&#39;Agostino-Pearson test 
                 reject Normality 
               
               
                 for Normal distribution 
                 (P &lt; 0.0001) 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Percentiles 
                   
                 95% Confidence interval 
               
               
                   
               
               
                 2.5 
                 0.0000 
                   
               
               
                 5 
                 0.0000 
                 0.0000 to 0.0000 
               
               
                 10 
                 0.0000 
                 0.0000 to 1.0000 
               
               
                 25 
                 1.0000 
                 1.0000 to 3.0000 
               
               
                 75 
                 11.0000 
                  8.0000 to 16.0956 
               
               
                 90 
                 22.0000 
                 16.8954 to 27.4692 
               
               
                 95 
                 26.7000 
                 22.0000 to 46.1766 
               
               
                 97.5 
                 30.9250 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 7A 
               
               
                   
               
               
                 Summary statistics 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                   
                 Non_Ulcerative_Colitis_90th_percentile 
               
               
                 Variable 
                 Non-Ulcerative Colitis 90th percentile 
               
               
                   
               
               
                 Sample size 
                 163     
               
               
                 Lowest value 
                 
                   0.0000 
                 
               
               
                 Highest value 
                   43.0000   
               
               
                 Arithmetic mean 
                 5.6687 
               
               
                 95% CI for the mean 
                 4.5255 to 6.8119 
               
               
                 Median 
                 3.0000 
               
               
                 95% CI for the median 
                 2.0000 to 4.0000 
               
               
                 Variance 
                 54.6303  
               
               
                 Standard deviation 
                 7.3912 
               
            
           
           
               
               
               
            
               
                 Relative standard deviation 
                 1.3039 
                 (130.39%) 
               
            
           
           
               
               
            
               
                 Standard error of the mean 
                 0.5789 
               
            
           
           
               
               
               
            
               
                 Coefficient of Skewness 
                 2.3467 
                 (P &lt; 0.0001) 
               
               
                 Coefficient of Kurtosis 
                 6.6923 
                 (P &lt; 0.0001) 
               
            
           
           
               
               
            
               
                 D&#39;Agostino-Pearson test 
                 reject Normality 
               
               
                 for Normal distribution 
                 (P &lt; 0.0001) 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Percentiles 
                   
                 95% Confidence interval 
               
               
                   
               
               
                 2.5 
                 0.0000 
                 0.0000 to 0.0000 
               
               
                 5 
                 0.0000 
                 0.0000 to 0.0000 
               
               
                 10 
                 0.0000 
                 0.0000 to 0.0000 
               
               
                 25 
                 1.0000 
                 0.0000 to 1.0000 
               
               
                 75 
                 8.0000 
                  5.6997 to 10.0000 
               
               
                 90 
                 15.0000 
                 11.0000 to 19.2863 
               
               
                 95 
                 20.3500 
                 16.5173 to 28.1987 
               
               
                 97.5 
                 26.0000 
                 20.1327 to 41.9327 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 7B 
               
               
                   
               
               
                 Summary statistics 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                   
                 Non_Ulcerative_Colitis_95th_percentile 
               
               
                 Variable 
                 Non-Ulcerative Colitis 95th percentile 
               
               
                   
               
               
                 Sample size 
                 163     
               
               
                 Lowest value 
                 
                   0.0000 
                 
               
               
                 Highest value 
                   31.0000   
               
               
                 Arithmetic mean 
                 2.8528 
               
               
                 95% CI far the mean 
                 2.1867 to 3.5189 
               
               
                 Median 
                 1.0000 
               
               
                 95% CI for the median 
                 1.0000 to 2.0000 
               
               
                 Variance 
                 18.5461  
               
               
                 Standard deviation 
                 4.3065 
               
            
           
           
               
               
               
            
               
                 Relative standard deviation 
                 1.5096 
                 (150.96%) 
               
            
           
           
               
               
            
               
                 Standard error of the mean 
                 0.3373 
               
            
           
           
               
               
               
            
               
                 Coefficient of Skewness 
                 2.9508 
                 (P &lt; 0.0001) 
               
               
                 Coefficient of Kurtosis 
                 12.1761 
                 (P &lt; 0.0001) 
               
            
           
           
               
               
            
               
                 D&#39;Agostino-Pearson test 
                 reject Normality 
               
               
                 for Normal distribution 
                 (P &lt; 0.0001) 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Percentiles 
                   
                 95% Confidence interval 
               
               
                   
               
               
                 2.5 
                 0.0000 
                 0.0000 to 0.0000 
               
               
                 5 
                 0.0000 
                 0.0000 to 0.0000 
               
               
                 10 
                 0.0000 
                 0.0000 to 0.0000 
               
               
                 25 
                 0.0000 
                 0.0000 to 1.0000 
               
               
                 75 
                 3.0000 
                 3.0000 to 5.0000 
               
               
                 90 
                 7.2000 
                  5.0000 to 13.0000 
               
               
                 95 
                 13.0000 
                 10.0000 to 15.3141 
               
               
                 97.5 
                 14.4250 
                 13.0000 to 28.0115 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 8A 
               
               
                   
               
               
                 Summary statistics 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                 Variable 
                 Ulcerative_Colitis_90th_parcentile_1 
               
               
                   
               
            
           
           
               
            
               
                 Back-transformed after logarithmic transformation. 
               
            
           
           
               
               
            
               
                 Sample size 
                 103     
               
               
                 Lowest value 
                 
                   0.1000 
                 
               
               
                 Highest value 
                   53.0000   
               
               
                 Geometric mean 
                 7.3070 
               
               
                 95% CI for the mean 
                 5.7021 to 9.3637 
               
               
                 Median 
                 8.0000 
               
               
                 95% CI for the median 
                  7.0000 to 11.0000 
               
            
           
           
               
               
               
            
               
                 Coefficient of Skewness 
                 −1.1403 
                 (P &lt; 0.0001) 
               
               
                 Coefficient of Kurtosis 
                 2.0327 
                 (P = 0.0056) 
               
            
           
           
               
               
            
               
                 D&#39;Agostino-Pearson test 
                 reject Normality 
               
               
                 for Normal distribution 
                 (P &lt; 0.0001) 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Percentiles 
                   
                 95% Confidence interval 
               
               
                   
               
               
                 2.5 
                 0.1189 
                   
               
               
                 5 
                 1.0000 
                 0.10000 to 1.2781  
               
               
                 10 
                 1.7411 
                 1.0000 to 2.0000 
               
               
                 25 
                 4.0000 
                 2.0000 to 5.0670 
               
               
                 75 
                 19.0000 
                 13.9245 to 25.0000 
               
               
                 90 
                 29.7592 
                 25.0000 to 37.0000 
               
               
                 95 
                 37.0000 
                 31.5247 to 50.6003 
               
               
                 97.5 
                 42.7754 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 8B 
               
               
                   
               
               
                 Summary statistics 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                 Variable 
                 Ulcerative_Colitis_95th_percentile_1 
               
               
                   
               
            
           
           
               
            
               
                 Back-transformed after logarithmic transformation. 
               
            
           
           
               
               
            
               
                 Sample size 
                 103     
               
               
                 Lowest value 
                 
                   0.1000 
                 
               
               
                 Highest value 
                   47.0000   
               
               
                 Geometric mean 
                 3.4690 
               
               
                 95% CI for the mean 
                 2.5190 to 4.7773 
               
               
                 Median 
                 5.0000 
               
               
                 95% CI for the median 
                 4.0000 to 6.9172 
               
            
           
           
               
               
               
            
               
                 Coefficient of Skewness 
                 −0.9013 
                 (P = 0.0005) 
               
               
                 Coefficient of Kurtosis 
                 0.1763 
                 (P = 0.5802) 
               
            
           
           
               
               
            
               
                 D&#39;Agostino-Pearson test 
                 reject Normality 
               
               
                 for Normal distribution 
                 (P = 0.0022) 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Percentiles 
                   
                 95% Confidence interval 
               
               
                   
               
               
                 2.5 
                 0.10000 
                   
               
               
                 5 
                 0.10000 
                 0.10000 to 0.10000 
               
               
                 10 
                 0.10000 
                 0.10000 to 1.0000  
               
               
                 25 
                 1.0000 
                 1.0000 to 3.0000 
               
               
                 75 
                 11.0000 
                  8.0000 to 16.0930 
               
               
                 90 
                 22.0000 
                 16.8926 to 27.4547 
               
               
                 95 
                 26.6832 
                 22.0000 to 46.1750 
               
               
                 97.5 
                 30.9316 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 9A 
               
               
                   
               
               
                 Summary statistics 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                   
                 Non_Ulcerative_Colitis_90th_percentile_1 
               
               
                 Variable 
                 Non-Ulcerative Colitis 90th percentile_1 
               
               
                   
               
            
           
           
               
            
               
                 Back-transformed after logarithmic transformation. 
               
            
           
           
               
               
            
               
                 Sample size 
                 163     
               
               
                 Lowest value 
                 
                   0.1000 
                 
               
               
                 Highest value 
                   43.0000   
               
               
                 Geometric mean 
                 2.1011 
               
               
                 95% CI for the mean 
                 1.6075 to 2.7463 
               
               
                 Median 
                 3.0000 
               
               
                 95% CI for the median 
                 2.0000 to 4.0000 
               
               
                 Coefficient of Skewness 
                 −0.6312 (P = 0.0016) 
               
               
                 Coefficient of Kurtosis 
                 −0.6026 (P = 0.0328) 
               
               
                 D&#39;Agostino-Pearson test 
                 reject Normality 
               
               
                 for Normal distribution 
                 (P = 0.0007) 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Percentiles 
                   
                 95% Confidence interval 
               
               
                   
               
               
                 2.5 
                 0.10000 
                 0.10000 to 0.10000 
               
               
                 5 
                 0.10000 
                 0.10000 to 0.10000 
               
               
                 10 
                 0.10000 
                 0.10000 to 0.10000 
               
               
                 25 
                 1.0000 
                 0.10000 to 1.0000  
               
               
                 75 
                 8.0000 
                  5.6803 to 10.1000 
               
               
                 90 
                 15.0000 
                 11.0000 to 19.3087 
               
               
                 95 
                 20.4105 
                 16.5098 to 28.0218 
               
               
                 97.5 
                 26.0000 
                 20.2171 to 41.6802 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 9B 
               
               
                   
               
               
                 Summary statistics 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                   
                 Non_Ulcerative_Colitis_95th_percentile_1 
               
               
                 Variable 
                 Non-Ulcerative Colitis 95th percentile 1 
               
               
                   
               
            
           
           
               
            
               
                 Back-transformed after logarithmic transformation. 
               
            
           
           
               
               
            
               
                 Sample size 
                 163     
               
               
                 Lowest value 
                 
                   0.1000 
                 
               
               
                 Highest value 
                   31.0000   
               
               
                 Geometric mean 
                 0.9669 
               
               
                 95% CI for the mean 
                 0.7444 to 1.2559 
               
               
                 Median 
                 1.0000 
               
               
                 95% CI for the median 
                 1.0000 to 2.0000 
               
            
           
           
               
               
               
            
               
                 Coefficient of Skewness 
                 −0.1914 
                 (P = 0.3069) 
               
               
                 Coefficient of Kurtosis 
                 −1.2156 
                 (P &lt; 0.0001) 
               
            
           
           
               
               
            
               
                 D&#39;Agostino-Pearson test 
                 reject Normality 
               
               
                 for Normal distribution 
                 (P &lt; 0.0001) 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Percentiles 
                   
                 95% Confidence interval 
               
               
                   
               
               
                 2.5 
                 0.10000 
                 0.10000 to 0.10000 
               
               
                 5 
                 0.10000 
                 0.10000 to 0.10000 
               
               
                 10 
                 0.10000 
                 0.10000 to 0.10000 
               
               
                 25 
                 0.10000 
                 0.10000 to 1.0000  
               
               
                 75 
                 3.0000 
                 3.0000 to 5.0000 
               
               
                 90 
                 7.1895 
                  5.0000 to 13.0000 
               
               
                 95 
                 13.0000 
                 10.1000 to 15.3072 
               
               
                 97.5 
                 14.4166 
                 13.0000 to 27.2688 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 10A 
               
               
                   
               
             
            
               
                 Independent samples t-test 
               
               
                   
               
               
                 Sample 1 
               
            
           
           
               
               
               
            
               
                   
                 Variable 
                 Non_Ulcerative_Colitis_90th_percentile_1 
               
               
                   
                   
                 Non-Ulcerative Colitis 90th percentile_1 
               
            
           
           
               
            
               
                 Sample 2 
               
            
           
           
               
               
               
            
               
                   
                 Variable 
                 Ulcerative_Colitis_90th_percentile_1 
               
            
           
           
               
            
               
                 Back-transformed after logarithmic transformation. 
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 Sample 1 
                 Sample 2 
               
               
                   
               
               
                 Sample size 
                 163 
                 103 
               
               
                 Geometric mean 
                 2.1011 
                 7.3070 
               
               
                 95% CI for the mean 
                 1.6075 to 2.7463 
                 5.7021 to 9.3637 
               
               
                 Variance of Logs 
                 0.5654 
                 0.3037 
               
               
                 F-test for equal variances 
                   
                 P = 0.001 
               
               
                   
               
            
           
           
               
            
               
                 T-test (assuming equal variances) 
               
               
                   
               
               
                 Difference on Log-transformed scale 
               
            
           
           
               
               
               
            
               
                   
                 Difference 
                 0.5413 
               
               
                   
                 Standard Error 
                 0.08577 
               
               
                   
                 95% CI of difference 
                 0.3724 to 0.7102 
               
               
                   
                 Test statistic t 
                 6.311 
               
               
                   
                 Degrees of Freedom (DF) 
                 264 
               
               
                   
                 Two-tailed probability 
                 P &lt; 0.0001 
               
            
           
           
               
            
               
                 Back-transformed results 
               
            
           
           
               
               
               
            
               
                   
                 Ratio of geometric means 
                 3.4776 
               
               
                   
                 95% CI of ratio 
                 2.3573 to 5.1305 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 10B 
               
               
                   
               
             
            
               
                 Independent samples t-test 
               
               
                   
               
               
                 Sample 1 
               
            
           
           
               
               
               
            
               
                   
                 Variable 
                 Non_Ulcerative_Colitis_95th_percentile_1 
               
               
                   
                   
                 Non-Ulcerative Colitis 95th percentile_1 
               
            
           
           
               
            
               
                 Sample 2 
               
            
           
           
               
               
               
            
               
                   
                 Variable 
                 Ulcerative_Colitis_—_—_95th_percentile_1 
               
               
                   
                   
                 Ulcerative Colitis 95th percentile_1 
               
            
           
           
               
            
               
                 Back-transformed after logarithmic transformation. 
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 Sample 1 
                 Sample 2 
               
               
                   
               
               
                 Sample size 
                 163 
                 103 
               
               
                 Geometric mean 
                 0.9669 
                 3.4690 
               
               
                 95% CI for the mean 
                 0.7444 to 1.2559 
                 2.5190 to 4.7773 
               
               
                 Variance of Logs 
                 0.5391 
                 0.5057 
               
               
                 F-test for equal variances 
                   
                 P = 0.731 
               
               
                   
               
            
           
           
               
            
               
                 T-test (assuming equal variances) 
               
               
                   
               
               
                 Difference on Log-transformed scale 
               
            
           
           
               
               
               
            
               
                   
                 Difference 
                 0.5548 
               
               
                   
                 Standard Error 
                 0.09131 
               
               
                   
                 95% CI of difference 
                 0.3751 to 0.7346 
               
               
                   
                 Test statistic t 
                 6.077 
               
               
                   
                 Degrees of Freedom (DF) 
                 264 
               
               
                   
                 Two-tailed probability 
                 P &lt; 0.0001 
               
            
           
           
               
            
               
                 Back-transformed results 
               
            
           
           
               
               
               
            
               
                   
                 Ratio of geometric means 
                 3.5879 
               
               
                   
                 95% CI of ratio 
                 2.3717 to 5.4278 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 11A 
               
               
                   
               
             
            
               
                 Mann-Whitney test (independent samples) 
               
               
                   
               
               
                 Sample 1 
               
            
           
           
               
               
               
            
               
                   
                 Variable 
                 Non_Ulcerative_Colitis_90th_percentile 
               
               
                   
                   
                 Non-Ulcerative Colitis 90th percentile 
               
            
           
           
               
            
               
                 Sample 2 
               
            
           
           
               
               
               
            
               
                   
                 Variable 
                 Ulcerative_Colitis_90th_percentile 
               
               
                   
                   
                 Ulcerative Colitis 90th percentile 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                   
                 Sample 1 
                 Sample 2 
               
               
                   
               
               
                   
                 Sample size 
                 163     
                 103     
               
               
                   
                 Lowest value 
                 
                   0.0000 
                 
                 
                   0.0000 
                 
               
               
                   
                 Highest value 
                   43.0000   
                   63.0000   
               
               
                   
                 Median 
                 3.0000 
                 8.0000 
               
               
                   
                 95% CI for the median 
                 2.0000 to 4.0000 
                 7.0000 to 11.0000 
               
               
                   
                 Interquartile range 
                 1.0000 to 8.0000 
                 4.0000 to 19.0000 
               
               
                   
               
            
           
           
               
            
               
                 Mann-Whitney test (independent samples) 
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 Average rank of first group 
                 110.8681 
               
               
                   
                 Average rank of second group 
                 169.3155 
               
               
                   
                 Mann-Whitney U 
                 4705.50 
               
               
                   
                 Test statistic Z (corrected for ties) 
                 6.053 
               
               
                   
                 Two-tailed probability 
                 P &lt; 0.0001 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 11B 
               
               
                   
               
             
            
               
                 Mann-Whitney test (independent samples) 
               
               
                   
               
               
                 Sample 1 
               
            
           
           
               
               
               
            
               
                   
                 Variable 
                 Non_Ulcerative_Colitis_95th_percentile 
               
               
                   
                   
                 Non-Ulcerative Colitis 95th percentile 
               
            
           
           
               
            
               
                 Sample 2 
               
            
           
           
               
               
               
            
               
                   
                 Variable 
                 Ulcerative_Colitis_95th_percentile 
               
               
                   
                   
                 Ulcerative Colitis 95th percentile 
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 Sample 1 
                 Sample 2 
               
               
                   
               
               
                 Sample size 
                 163     
                 103     
               
               
                 Lowest value 
                 
                   0.0000 
                 
                 
                   0.0000 
                 
               
               
                 Highest value 
                   31.0000   
                   47.0000   
               
               
                 Median 
                 1.0000 
                 5.0000 
               
               
                 95% CI for the median 
                 1.0000 to 2.0000 
                 4.0000 to 6.9228 
               
               
                 Interquartile range 
                 0.0000 to 3.0000 
                  1.0000 to 11.0000 
               
               
                   
               
            
           
           
               
            
               
                 Mann-Whitney test (independent samples) 
               
               
                   
               
            
           
           
               
               
               
            
               
                   
                 Average rank of first group 
                 110.9939 
               
               
                   
                 Average rank of second group 
                 169.1165 
               
               
                   
                 Mann-Whitney U 
                 4726.00 
               
               
                   
                 Test statistic Z (corrected for ties) 
                 6.068 
               
               
                   
                 Two-tailed probability 
                 P &lt; 0.0001 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 12A 
               
               
                   
               
             
            
               
                 ROC curve 
               
            
           
           
               
               
            
               
                 Variable 
                 Ulcerative_Colitis_Test_90th 
               
               
                   
                 Ulcerative Colitis Test_90th 
               
               
                 Classification variable 
                 Diagnosis_—1_Ulcerative_Colitis_0_Non_Ulcerative_Colitis_ 
               
               
                   
                 Diagnosis(1_Ulcerative Colitis 0_Non-Ulcerative Colitis) 
               
               
                 Sample size 
                 266 
               
               
                 Positive group a    
                 103 (38.72%) 
               
               
                 Negative group b   
                 162 (61.28%) 
               
               
                   
               
            
           
           
               
            
               
                   a Diagnosis_—1_Ulcerative_Colitis_0_Non_Ulcerative_Colitis_ = 1 
               
               
                   b Diagnosis_—1_Ulcerative_Colitis_0_Non_Ulcerative_Colitis_ = 0 
               
            
           
           
               
               
            
               
                 Disease prevalence (%) 
                 unknown 
               
            
           
           
               
            
               
                 Area under the ROC curve (AUC) 
               
            
           
           
               
               
            
               
                 Area under the ROC curve (AUC) 
                 0.720 
               
               
                 Standard Error a   
                 0.0315 
               
               
                 95% Confidence interval b   
                 0.662 to 0.773 
               
               
                 z statistic 
                 6.966 
               
               
                 Significance level P (Area = 0.5) 
                 &lt;0.0001 
               
               
                   
               
            
           
           
               
            
               
                   a DeLong et al., 1988 
               
               
                   b Binomial exact 
               
               
                 Youden index 
               
            
           
           
               
               
            
               
                 Youden index J 
                 0.3412 
               
               
                 95% Confidence interval a   
                 0.2311 to 0.4414 
               
               
                 Associated criterion 
                 &gt;5 
               
               
                 95% Confidence interval a   
                 &gt;2 to &gt;9 
               
               
                 Sensitivity 
                 66.02 
               
               
                 Specificity 
                 68.10 
               
               
                   
               
            
           
           
               
            
               
                   a BC a bootstrap confidence interval (1000 iterations: random number seed: 978). 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 12B 
               
               
                   
               
             
            
               
                 ROC curve 
               
            
           
           
               
               
            
               
                 Variable 
                 Ulcerative_Colitis_Test_95th 
               
               
                   
                 Ulcerative Colitis Test_95th 
               
               
                 Classification variable 
                 Diagnosis_—1_Ulcerative_Colitis_0_Non_Ulcerative_Colitis_ 
               
               
                   
                 Diaonosis(1_Ulcerative Colitis 0_Non-Ulcerative Colitis) 
               
               
                 Sample size 
                 266 
               
               
                 Positive group a   
                 103 (38.72%) 
               
               
                 Negative group b   
                 163 (61.28%) 
               
               
                   
               
            
           
           
               
            
               
                   a Diagnosis 1_—Ulcerative_Colitis_0_Non_Ulcerative_Colitis_ = 1 
               
               
                   b Diagnosis 1_—Ulcerative_Colitis_0_Non_Ulcerative_Colitis_ = 0 
               
            
           
           
               
               
            
               
                 Disease prevalence (%) 
                 unknown 
               
            
           
           
               
            
               
                 Area under the ROC curve (AUC) 
               
            
           
           
               
               
            
               
                 Area under the ROC curve (AUC) 
                 0.719 
               
               
                 Standard Error a   
                 0.0325 
               
               
                 95% Confidence interval b   
                 0.660 to 0.772 
               
               
                 z statistic 
                 6.715 
               
               
                 Significance level P (Area = 0.5) 
                 &lt;0.0001 
               
               
                   
               
            
           
           
               
            
               
                   a DeLong et al., 1988 
               
               
                   b Binomial exact 
               
               
                 Youden index 
               
            
           
           
               
               
            
               
                 Youden index J 
                 0.3565 
               
               
                 95% Confidence interval a   
                 0.2058 to 0.4465 
               
               
                 Associated criterion 
                 &gt;3 
               
               
                 95% Confidence interval a   
                 &gt;2 to &gt;5 
               
               
                 Sensitivity 
                 60.19 
               
               
                 Specificity 
                 75.46 
               
               
                   
               
            
           
           
               
            
               
                   a BC a bootstrap confidence interval (1000 iterations: random number seed: 978). 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 13A 
               
             
            
               
                   
               
               
                 Performance Metrics in Predicting Ulcerative Colitis 
               
               
                 Status from Number of Positive Foods Using 90th Percentile 
               
               
                 of ELISA Signal to determine Positive 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                 No. of 
                   
                   
                   
                   
                   
               
               
                   
                 Positive 
                   
                   
                   
                   
                 Overall 
               
               
                   
                 Foods 
                   
                   
                 Positive 
                 Negative 
                 Percent 
               
               
                   
                 as 
                 Sensi- 
                 Speci- 
                 Predictive 
                 Predictive 
                 Agree- 
               
               
                 Sex 
                 Cutoff 
                 tivity 
                 ficity 
                 Value 
                 Value 
                 ment 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 FEMALE 
                 1 
                 0.97 
                 0.14 
                 0.49 
                 0.83 
                 0.52 
               
               
                   
                 2 
                 0.92 
                 0.29 
                 0.52 
                 0.80 
                 0.58 
               
               
                   
                 3 
                 0.85 
                 0.40 
                 0.55 
                 0.75 
                 0.61 
               
               
                   
                 4 
                 0.76 
                 0.49 
                 0.56 
                 0.71 
                 0.62 
               
               
                   
                 5 
                 0.69 
                 0.57 
                 0.58 
                 0.68 
                 0.62 
               
               
                   
                 6 
                 0.62 
                 0.62 
                 0.58 
                 0.65 
                 0.62 
               
               
                   
                 7 
                 0.55 
                 0.66 
                 0.58 
                 0.63 
                 0.61 
               
               
                   
                 8 
                 0.49 
                 0.69 
                 0.57 
                 0.61 
                 0.60 
               
               
                   
                 9 
                 0.44 
                 0.72 
                 0.57 
                 0.60 
                 0.59 
               
               
                   
                 10 
                 0.39 
                 0.75 
                 0.58 
                 0.59 
                 0.58 
               
               
                   
                 11 
                 0.34 
                 0.78 
                 0.58 
                 0.58 
                 0.58 
               
               
                   
                 12 
                 0.31 
                 0.81 
                 0.59 
                 0.58 
                 0.58 
               
               
                   
                 13 
                 0.28 
                 0.83 
                 0.59 
                 0.57 
                 0.58 
               
               
                   
                 14 
                 0.25 
                 0.84 
                 0.58 
                 0.56 
                 0.57 
               
               
                   
                 15 
                 0.23 
                 0.85 
                 0.57 
                 0.56 
                 0.56 
               
               
                   
                 16 
                 0.21 
                 0.86 
                 0.57 
                 0.56 
                 0.56 
               
               
                   
                 17 
                 0.20 
                 0.87 
                 0.57 
                 0.56 
                 0.56 
               
               
                   
                 18 
                 0.19 
                 0.88 
                 0.58 
                 0.56 
                 0.56 
               
               
                   
                 19 
                 0.18 
                 0.90 
                 0.60 
                 0.56 
                 0.56 
               
               
                   
                 20 
                 0.17 
                 0.91 
                 0.63 
                 0.56 
                 0.57 
               
               
                   
                 21 
                 0.16 
                 0.93 
                 0.64 
                 0.56 
                 0.57 
               
               
                   
                 22 
                 0.15 
                 0.93 
                 0.67 
                 0.56 
                 0.57 
               
               
                   
                 23 
                 0.15 
                 0.95 
                 0.67 
                 0.56 
                 0.57 
               
               
                   
                 24 
                 0.14 
                 0.95 
                 0.71 
                 0.56 
                 0.57 
               
               
                   
                 25 
                 0.13 
                 0.95 
                 0.71 
                 0.56 
                 0.57 
               
               
                   
                 26 
                 0.11 
                 0.96 
                 0.71 
                 0.56 
                 0.57 
               
               
                   
                 27 
                 0.11 
                 0.97 
                 0.75 
                 0.56 
                 0.57 
               
               
                   
                 28 
                 0.09 
                 0.98 
                 0.75 
                 0.55 
                 0.57 
               
               
                   
                 29 
                 0.08 
                 0.98 
                 0.80 
                 0.55 
                 0.57 
               
               
                   
                 30 
                 0.08 
                 1.00 
                 1.00 
                 0.55 
                 0.57 
               
               
                   
                 31 
                 0.08 
                 1.00 
                 1.00 
                 0.55 
                 0.57 
               
               
                   
                 32 
                 0.07 
                 1.00 
                 1.00 
                 0.55 
                 0.57 
               
               
                   
                 33 
                 0.07 
                 1.00 
                 1.00 
                 0.55 
                 0.57 
               
               
                   
                 34 
                 0.06 
                 1.00 
                 1.00 
                 0.55 
                 0.56 
               
               
                   
                 35 
                 0.06 
                 1.00 
                 1.00 
                 0.55 
                 0.56 
               
               
                   
                 36 
                 0.06 
                 1.00 
                 1.00 
                 0.55 
                 0.56 
               
               
                   
                 37 
                 0.05 
                 1.00 
                 1.00 
                 0.55 
                 0.56 
               
               
                   
                 38 
                 0.05 
                 1.00 
                 1.00 
                 0.55 
                 0.56 
               
               
                   
                 39 
                 0.05 
                 1.00 
                 1.00 
                 0.55 
                 0.56 
               
               
                   
                 40 
                 0.03 
                 1.00 
                 1.00 
                 0.55 
                 0.55 
               
               
                   
                 41 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 42 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 43 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 44 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 45 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 46 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 47 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 48 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 49 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 50 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 51 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 52 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.54 
               
               
                   
                 53 
                 0.02 
                 1.00 
                 1.00 
                 0.54 
                 0.54 
               
               
                   
                 54 
                 0.00 
                 1.00 
                 1.00 
                 0.54 
                 0.54 
               
               
                   
                 55 
                 0.00 
                 1.00 
                 1.00 
                 0.54 
                 0.54 
               
               
                   
                 56 
                 0.00 
                 1.00 
                 1.00 
                 0.54 
                 0.54 
               
               
                   
                 57 
                 0.00 
                 1.00 
                 . 
                 0.53 
                 0.53 
               
               
                   
                 58 
                 0.00 
                 1.00 
                 . 
                 0.53 
                 0.53 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 13B 
               
             
            
               
                   
               
               
                 Performance Metrics in Predicting Ulcerative Colitis 
               
               
                 Status from Number of Positive Foods Using 90th Percentile 
               
               
                 of ELISA Signal to determine Positive 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                 No. of 
                   
                   
                   
                   
                   
               
               
                   
                 Positive 
                   
                   
                   
                   
                 Overall 
               
               
                   
                 Foods 
                   
                   
                 Positive 
                 Negative 
                 Percent 
               
               
                   
                 as 
                 Sensi- 
                 Speci- 
                 Predictive 
                 Predictive 
                 Agree- 
               
               
                 Sex 
                 Cutoff 
                 tivity 
                 ficity 
                 Value 
                 Value 
                 ment 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 MALE 
                 1 
                 0.97 
                 0.15 
                 0.35 
                 0.90 
                 0.41 
               
               
                   
                 2 
                 0.94 
                 0.29 
                 0.38 
                 0.91 
                 0.49 
               
               
                   
                 3 
                 0.88 
                 0.42 
                 0.42 
                 0.88 
                 0.57 
               
               
                   
                 4 
                 0.84 
                 0.50 
                 0.45 
                 0.87 
                 0.61 
               
               
                   
                 5 
                 0.81 
                 0.56 
                 0.47 
                 0.86 
                 0.64 
               
               
                   
                 6 
                 0.77 
                 0.63 
                 0.49 
                 0.85 
                 0.67 
               
               
                   
                 7 
                 0.72 
                 0.68 
                 0.51 
                 0.84 
                 0.69 
               
               
                   
                 8 
                 0.67 
                 0.72 
                 0.53 
                 0.82 
                 0.71 
               
               
                   
                 9 
                 0.64 
                 0.76 
                 0.56 
                 0.81 
                 0.72 
               
               
                   
                 10 
                 0.59 
                 0.79 
                 0.57 
                 0.80 
                 0.73 
               
               
                   
                 11 
                 0.56 
                 0.82 
                 0.59 
                 0.80 
                 0.73 
               
               
                   
                 12 
                 0.54 
                 0.84 
                 0.62 
                 0.79 
                 0.74 
               
               
                   
                 13 
                 0.52 
                 0.86 
                 0.64 
                 0.79 
                 0.75 
               
               
                   
                 14 
                 0.50 
                 0.87 
                 0.65 
                 0.78 
                 0.75 
               
               
                   
                 15 
                 0.46 
                 0.89 
                 0.67 
                 0.78 
                 0.75 
               
               
                   
                 16 
                 0.44 
                 0.90 
                 0.68 
                 0.77 
                 0.75 
               
               
                   
                 17 
                 0.42 
                 0.92 
                 0.71 
                 0.77 
                 0.76 
               
               
                   
                 18 
                 0.39 
                 0.93 
                 0.71 
                 0.76 
                 0.76 
               
               
                   
                 19 
                 0.38 
                 0.93 
                 0.71 
                 0.76 
                 0.75 
               
               
                   
                 20 
                 0.36 
                 0.94 
                 0.73 
                 0.75 
                 0.75 
               
               
                   
                 21 
                 0.34 
                 0.94 
                 0.73 
                 0.75 
                 0.75 
               
               
                   
                 22 
                 0.32 
                 0.95 
                 0.73 
                 0.75 
                 0.75 
               
               
                   
                 23 
                 0.31 
                 0.95 
                 0.75 
                 0.74 
                 0.75 
               
               
                   
                 24 
                 0.30 
                 0.95 
                 0.75 
                 0.74 
                 0.74 
               
               
                   
                 25 
                 0.28 
                 0.95 
                 0.75 
                 0.74 
                 0.74 
               
               
                   
                 26 
                 0.27 
                 0.96 
                 0.75 
                 0.73 
                 0.73 
               
               
                   
                 27 
                 0.23 
                 0.96 
                 0.75 
                 0.73 
                 0.73 
               
               
                   
                 28 
                 0.21 
                 0.97 
                 0.73 
                 0.72 
                 0.72 
               
               
                   
                 29 
                 0.18 
                 0.97 
                 0.71 
                 0.71 
                 0.71 
               
               
                   
                 30 
                 0.16 
                 0.97 
                 0.70 
                 0.71 
                 0.71 
               
               
                   
                 31 
                 0.14 
                 0.97 
                 0.67 
                 0.71 
                 0.71 
               
               
                   
                 32 
                 0.13 
                 0.97 
                 0.67 
                 0.70 
                 0.70 
               
               
                   
                 33 
                 0.12 
                 0.97 
                 0.67 
                 0.70 
                 0.70 
               
               
                   
                 34 
                 0.11 
                 0.97 
                 0.67 
                 0.70 
                 0.70 
               
               
                   
                 35 
                 0.10 
                 0.98 
                 0.67 
                 0.70 
                 0.70 
               
               
                   
                 36 
                 0.08 
                 0.98 
                 0.67 
                 0.69 
                 0.69 
               
               
                   
                 37 
                 0.07 
                 0.98 
                 0.67 
                 0.69 
                 0.69 
               
               
                   
                 38 
                 0.06 
                 0.98 
                 0.50 
                 0.69 
                 0.68 
               
               
                   
                 39 
                 0.04 
                 0.98 
                 0.50 
                 0.69 
                 0.68 
               
               
                   
                 40 
                 0.03 
                 0.98 
                 0.50 
                 0.68 
                 0.68 
               
               
                   
                 41 
                 0.03 
                 0.98 
                 0.50 
                 0.68 
                 0.68 
               
               
                   
                 42 
                 0.00 
                 0.98 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 43 
                 0.00 
                 0.98 
                 0.00 
                 0.68 
                 0.67 
               
               
                   
                 44 
                 0.00 
                 0.98 
                 0.00 
                 0.68 
                 0.67 
               
               
                   
                 45 
                 0.00 
                 0.99 
                 0.00 
                 0.68 
                 0.67 
               
               
                   
                 46 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.67 
               
               
                   
                 47 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.67 
               
               
                   
                 48 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.67 
               
               
                   
                 49 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 50 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 51 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 52 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 53 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 54 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 55 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 56 
                 0.00 
                 1.00 
                 . 
                 0.68 
                 0.68 
               
               
                   
                 57 
                 0.00 
                 1.00 
                 . 
                 0.68 
                 0.68 
               
               
                   
                 58 
                 0.00 
                 1.00 
                 . 
                 0.68 
                 0.68 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 14A 
               
             
            
               
                   
               
               
                 Performance Metrics in Predicting Ulcerative Colitis 
               
               
                 Status from Number of Positive Foods Using 95th Percentile 
               
               
                 of ELISA Signal to determine Positive 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                 No. of 
                   
                   
                   
                   
                   
               
               
                   
                 Positive 
                   
                   
                   
                   
                 Overall 
               
               
                   
                 Foods 
                   
                   
                 Positive 
                 Negative 
                 Percent 
               
               
                   
                 as 
                 Sensi- 
                 Speci- 
                 Predictive 
                 Predictive 
                 Agree- 
               
               
                 Sex 
                 Cutoff 
                 tivity 
                 ficity 
                 Value 
                 Value 
                 ment 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 FEMALE 
                 1 
                 0.89 
                 0.27 
                 0.51 
                 0.74 
                 0.56 
               
               
                   
                 2 
                 0.75 
                 0.45 
                 0.54 
                 0.68 
                 0.59 
               
               
                   
                 3 
                 0.65 
                 0.58 
                 0.57 
                 0.66 
                 0.61 
               
               
                   
                 4 
                 0.55 
                 0.65 
                 0.58 
                 0.63 
                 0.61 
               
               
                   
                 5 
                 0.49 
                 0.72 
                 0.60 
                 0.62 
                 0.62 
               
               
                   
                 6 
                 0.44 
                 0.76 
                 0.61 
                 0.61 
                 0.61 
               
               
                   
                 7 
                 0.38 
                 0.80 
                 0.63 
                 0.60 
                 0.61 
               
               
                   
                 8 
                 0.33 
                 0.83 
                 0.63 
                 0.59 
                 0.60 
               
               
                   
                 9 
                 0.29 
                 0.85 
                 0.63 
                 0.58 
                 0.59 
               
               
                   
                 10 
                 0.25 
                 0.87 
                 0.63 
                 0.57 
                 0.58 
               
               
                   
                 11 
                 0.22 
                 0.88 
                 0.62 
                 0.57 
                 0.58 
               
               
                   
                 12 
                 0.19 
                 0.90 
                 0.63 
                 0.56 
                 0.57 
               
               
                   
                 13 
                 0.18 
                 0.91 
                 0.64 
                 0.56 
                 0.57 
               
               
                   
                 14 
                 0.18 
                 0.93 
                 0.67 
                 0.56 
                 0.58 
               
               
                   
                 15 
                 0.17 
                 0.94 
                 0.70 
                 0.57 
                 0.58 
               
               
                   
                 16 
                 0.15 
                 0.95 
                 0.75 
                 0.57 
                 0.58 
               
               
                   
                 17 
                 0.14 
                 0.97 
                 0.80 
                 0.57 
                 0.58 
               
               
                   
                 18 
                 0.13 
                 0.98 
                 0.83 
                 0.56 
                 0.58 
               
               
                   
                 19 
                 0.11 
                 0.98 
                 0.88 
                 0.56 
                 0.58 
               
               
                   
                 20 
                 0.11 
                 1.00 
                 1.00 
                 0.56 
                 0.58 
               
               
                   
                 21 
                 0.09 
                 1.00 
                 1.00 
                 0.56 
                 0.58 
               
               
                   
                 22 
                 0.08 
                 1.00 
                 1.00 
                 0.56 
                 0.57 
               
               
                   
                 23 
                 0.08 
                 1.00 
                 1.00 
                 0.55 
                 0.57 
               
               
                   
                 24 
                 0.06 
                 1.00 
                 1.00 
                 0.55 
                 0.57 
               
               
                   
                 25 
                 0.06 
                 1.00 
                 1.00 
                 0.55 
                 0.56 
               
               
                   
                 26 
                 0.06 
                 1.00 
                 1.00 
                 0.55 
                 0.56 
               
               
                   
                 27 
                 0.06 
                 1.00 
                 1.00 
                 0.55 
                 0.56 
               
               
                   
                 28 
                 0.06 
                 1.00 
                 1.00 
                 0.55 
                 0.56 
               
               
                   
                 29 
                 0.05 
                 1.00 
                 1.00 
                 0.55 
                 0.56 
               
               
                   
                 30 
                 0.05 
                 1.00 
                 1.00 
                 0.55 
                 0.56 
               
               
                   
                 31 
                 0.05 
                 1.00 
                 1.00 
                 0.55 
                 0.56 
               
               
                   
                 32 
                 0.05 
                 1.00 
                 1.00 
                 0.55 
                 0.56 
               
               
                   
                 33 
                 0.03 
                 1.00 
                 1.00 
                 0.55 
                 0.55 
               
               
                   
                 34 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 35 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 36 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 37 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 38 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 39 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 40 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 41 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 42 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 43 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 44 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 45 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 46 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.55 
               
               
                   
                 47 
                 0.03 
                 1.00 
                 1.00 
                 0.54 
                 0.54 
               
               
                   
                 48 
                 0.00 
                 1.00 
                 1.00 
                 0.54 
                 0.54 
               
               
                   
                 49 
                 0.00 
                 1.00 
                 1.00 
                 0.54 
                 0.54 
               
               
                   
                 50 
                 0.00 
                 1.00 
                 1.00 
                 0.54 
                 0.54 
               
               
                   
                 51 
                 0.00 
                 1.00 
                 1.00 
                 0.54 
                 0.54 
               
               
                   
                 52 
                 0.00 
                 1.00 
                 1.00 
                 0.54 
                 0.54 
               
               
                   
                 53 
                 0.00 
                 1.00 
                 1.00 
                 0.53 
                 0.53 
               
               
                   
                 54 
                 0.00 
                 1.00 
                 1.00 
                 0.53 
                 0.53 
               
               
                   
                 55 
                 0.00 
                 1.00 
                 1.00 
                 0.53 
                 0.53 
               
               
                   
                 56 
                 0.00 
                 1.00 
                 . 
                 0.53 
                 0.53 
               
               
                   
                 57 
                 0.00 
                 1.00 
                 . 
                 0.53 
                 0.53 
               
               
                   
                 58 
                 0.00 
                 1.00 
                 . 
                 0.53 
                 0.53 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 14B 
               
             
            
               
                   
               
               
                 Performance Metrics in Predicting Ulcerative Colitis 
               
               
                 Status from Number of Positive Foods Using 95th Percentile 
               
               
                 of ELISA Signal to determine Positive 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                 No. of 
                   
                   
                   
                   
                   
               
               
                   
                 Positive 
                   
                   
                   
                   
                 Overall 
               
               
                   
                 Foods 
                   
                   
                 Positive 
                 Negative 
                 Percent 
               
               
                   
                 as 
                 Sensi- 
                 Speci- 
                 Predictive 
                 Predictive 
                 Agree- 
               
               
                 Sex 
                 Cutoff 
                 tivity 
                 ficity 
                 Value 
                 Value 
                 ment 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 MALE 
                 1 
                 0.90 
                 0.25 
                 0.36 
                 0.85 
                 0.46 
               
               
                   
                 2 
                 0.83 
                 0.48 
                 0.43 
                 0.86 
                 0.59 
               
               
                   
                 3 
                 0.79 
                 0.64 
                 0.51 
                 0.87 
                 0.69 
               
               
                   
                 4 
                 0.74 
                 0.72 
                 0.55 
                 0.85 
                 0.72 
               
               
                   
                 5 
                 0.64 
                 0.78 
                 0.58 
                 0.82 
                 0.73 
               
               
                   
                 6 
                 0.58 
                 0.83 
                 0.62 
                 0.80 
                 0.75 
               
               
                   
                 7 
                 0.53 
                 0.87 
                 0.65 
                 0.79 
                 0.76 
               
               
                   
                 8 
                 0.48 
                 0.89 
                 0.67 
                 0.78 
                 0.76 
               
               
                   
                 9 
                 0.44 
                 0.91 
                 0.69 
                 0.77 
                 0.76 
               
               
                   
                 10 
                 0.40 
                 0.92 
                 0.69 
                 0.76 
                 0.75 
               
               
                   
                 11 
                 0.36 
                 0.92 
                 0.69 
                 0.75 
                 0.74 
               
               
                   
                 12 
                 0.33 
                 0.93 
                 0.69 
                 0.75 
                 0.74 
               
               
                   
                 13 
                 0.31 
                 0.93 
                 0.69 
                 0.74 
                 0.73 
               
               
                   
                 14 
                 0.30 
                 0.94 
                 0.70 
                 0.74 
                 0.73 
               
               
                   
                 15 
                 0.28 
                 0.95 
                 0.73 
                 0.74 
                 0.73 
               
               
                   
                 16 
                 0.27 
                 0.95 
                 0.73 
                 0.73 
                 0.73 
               
               
                   
                 17 
                 0.24 
                 0.96 
                 0.75 
                 0.73 
                 0.73 
               
               
                   
                 18 
                 0.22 
                 0.97 
                 0.75 
                 0.72 
                 0.73 
               
               
                   
                 19 
                 0.20 
                 0.97 
                 0.75 
                 0.72 
                 0.72 
               
               
                   
                 20 
                 0.19 
                 0.97 
                 0.75 
                 0.72 
                 0.72 
               
               
                   
                 21 
                 0.17 
                 0.97 
                 0.75 
                 0.71 
                 0.72 
               
               
                   
                 22 
                 0.14 
                 0.98 
                 0.75 
                 0.71 
                 0.71 
               
               
                   
                 23 
                 0.12 
                 0.98 
                 0.75 
                 0.70 
                 0.70 
               
               
                   
                 24 
                 0.10 
                 0.98 
                 0.67 
                 0.70 
                 0.70 
               
               
                   
                 25 
                 0.08 
                 0.98 
                 0.67 
                 0.69 
                 0.70 
               
               
                   
                 26 
                 0.07 
                 0.98 
                 0.67 
                 0.69 
                 0.69 
               
               
                   
                 27 
                 0.06 
                 0.98 
                 0.67 
                 0.69 
                 0.69 
               
               
                   
                 28 
                 0.04 
                 0.98 
                 0.67 
                 0.69 
                 0.69 
               
               
                   
                 29 
                 0.04 
                 0.98 
                 0.50 
                 0.69 
                 0.68 
               
               
                   
                 30 
                 0.03 
                 0.98 
                 0.50 
                 0.68 
                 0.68 
               
               
                   
                 31 
                 0.03 
                 0.98 
                 0.50 
                 0.68 
                 0.68 
               
               
                   
                 32 
                 0.00 
                 0.99 
                 0.50 
                 0.68 
                 0.68 
               
               
                   
                 33 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 34 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 35 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.67 
               
               
                   
                 36 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.67 
               
               
                   
                 37 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 38 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 39 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 40 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 41 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 42 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 43 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 44 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 45 
                 0.00 
                 1.00 
                 0.00 
                 0.68 
                 0.68 
               
               
                   
                 46 
                 0.00 
                 1.00 
                 . 
                 0.68 
                 0.68 
               
               
                   
                 47 
                 0.00 
                 1.00 
                 . 
                 0.68 
                 0.68 
               
               
                   
                 48 
                 0.00 
                 1.00 
                 . 
                 0.68 
                 0.68 
               
               
                   
                 49 
                 0.00 
                 1.00 
                 . 
                 0.68 
                 0.68 
               
               
                   
                 50 
                 0.00 
                 1.00 
                 . 
                 0.68 
                 0.68 
               
               
                   
                 51 
                 0.00 
                 1.00 
                 . 
                 0.68 
                 0.68 
               
               
                   
                 52 
                 0.00 
                 1.00 
                 . 
                 0.68 
                 0.68 
               
               
                   
                 53 
                 0.00 
                 1.00 
                 . 
                 0.68 
                 0.68 
               
               
                   
                 54 
                 0.00 
                 1.00 
                 . 
                 0.68 
                 0.68 
               
               
                   
                 55 
                 0.00 
                 1.00 
                 . 
                 0.68 
                 0.68 
               
               
                   
                 56 
                 0.00 
                 1.00 
                 . 
                 0.68 
                 0.68 
               
               
                   
                 57 
                 0.00 
                 1.00 
                 . 
                 0.68 
                 0.68 
               
               
                   
                 58 
                 0.00 
                 1.00 
                 . 
                 0.68 
                 0.68