Patent Publication Number: US-2011071141-A1

Title: Pesticidial Condensed-Ring Aryl Compounds

Description:
The present invention relates to novel condensed-ring aryl compounds and use of the same as a agrochemical for controlling noxious organisms. 
     From Japanese Patent Application Laid-open No. 2007-91708 it known that dihydroazole-substituted benzamide compounds may be used as noxious organism control agent. The same is true for the 5-membered heterocyclic compounds as described in WO2007/12 3853 and for the pyrazoline compounds as described in WO2007/12 3855. 
     It is also known that certain isoxazoline derivatives can be used as noxious organisms control agent (e.g. WO2005/085216, WO2007/026965, WO2007/074789, WO2007/070606, WO2007/075459, WO2007/079162, WO2007/105814, WO2007/12 5984, Japanese Patent Application Laid-open No. 2007-16017, Japanese Patent Application Laid-open No. 2007-106756, and Japanese Patent Application Laid-open No. 2007-308471, WO2007/026965, and WO2007/105814). 
     WO2005/085216 and its English equivalent EP-A-1 731 512 discloses certain arylisoxazoline compounds having condensed rings and which are supposed to exhibit insecticidal action. 
     Inventors of the present invention intensively studied to develop a novel pesticidal compound which exhibits a excellent pesticidal effect and has a broad spectrum. As a result, the inventors found novel condensed-ring aryl compounds, which have high activity, a broad spectrum and safety and also are effective against pests that are resistant to an organic phosphorous agent or a carbamate agent. 
     Thus, this invention is directed to condensed-ring aryl compounds of formula (I) 
     
       
         
         
             
             
         
       
         
         
           
             wherein 
             X represents halogen; nitro; cyano; hydroxy; thiol; amino; C 1-12  alkyl, C 1-12  haloalkyl, C 1-12  alkoxy, C 1-12  haloalkoxy, C 1-12  alkylsulfenyl, C 1-12  alkylsulfinyl, C 1-12  alkyl-sulfonyl, C 1-12 haloalkylsulfenyl, C 1-12  haloalkylsulfinyl, C 1-12 haloalkylsulfonyl, C 1-12  alkylamino, C 2-24  dialkylamino, C 1-12  acylamino, C 1-12  alkoxy-carbonylamino, C 1-12  haloalkoxy-carbonylamino, C 1-12  alkylsulfonylamino, or C 1-12  haloalkylsulfonylamino; preferably chloro, bromo, iodo, fluoro; nitro; cyano; hydroxy; thiol; amino; C 1-6  alkyl, C 1-6 haloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, C 1-6  alkylsulfenyl, C 1-6 alkylsulfinyl, C 1-6  alkylsulfonyl, C 1-6  haloalkylsulfenyl, C 1-6  haloalkylsulfinyl, C 1-6 haloalkylsulfonyl, C 1-6  alkylamino, C 2-12  (total carbon number) dialkylamino, C 1-6  acylamino, C 1-6 alkoxy-carbonylamino, C 1-6 haloalkoxy-carbonylamino, C 1-6  alkylsulfonylamino, or C 1-6  haloalkylsulfonylamino; 
             Q represents substitutable phenyl, substitutable naphtyl or a substitutable 5- or 6-membered heterocyclic group; preferably represents a optionally substituted group selected among Q-1 to Q-54 
           
         
       
    
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
         
         
           
             Y represents halogen; nitro; cyano; hydroxy; thiol; amino; C 1-12  alkyl, C 1-12  haloalkyl, C 3-8  cycloalkyl, C 3-8  cyclohaloalkyl, C 1-12  alkenyl, C 2-12  haloalkenyl, C 1-12  alkoxy, C 1-12  haloalkoxy, C 1-12  alkylsulfenyl, C 1-12  alkylsulfinyl, C 1-12  alkylsulfonyl, C 1-12  haloalkylsulfenyl, C 1-12  haloalkylsulfinyl, C 1-12  haloalkylsulfonyl, C 1-12  alkylamino, C 2-24  (total carbon number) dialkyl-amino, C 1-12  aminocarbonyl, C 1-12  alkylamino-carbonyl, C 2-24  (total carbon number) dialkylamino-1-carbonyl, C 1-12  acylamino, C 1-12  alkoxy-carbonylamino, benzyloxy-carbonylamino, C 1-12  (haloalkoxy)-carbonylamino, C 1-12  alkylsulfonylamino, C 1-12  haloalkylsulfonylamino, or C 3-36  (total carbon number) trialkylsilyl; preferably represents chloro, bromo, iodo, fluoro; nitro; cyano; hydroxy; thiol; amino; C 1-6  alkyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, C 3-6  cyclohaloalkyl, C 1-6  alkenyl, haloalkenyl, C 1-6  alkoxy, C 1-6  haloalkoxy, C 1-6  alkylsulfenyl, C 1-6  alkylsulfinyl, C 1-6  alkylsulfonyl, C 1-6  haloalkylsulfenyl, C 1-6  haloalkylsulfinyl, C 1-6  haloalkylsulfonyl, C 1-6  alkyl-amino, C 2-12  (total carbon number) dialkylamino, aminocarbonyl, C 1-6  alkylamino-carbonyl, C 2-12  (total carbon number) dialkylamino-carbonyl, C 1-6  acylamino, C 1-6  alkoxy-carbonylamino, benzyloxy-carbonylamino, C 1-6  (haloalkoxy)-carbonylamino, C 1-6  alkylsulfonylamino, C 1-6  haloalkylsulfonylamino, or C 3-18  (total carbon number) trialkylsilyl; more preferably represents chloro, bromo, iodo, fluoro; nitro; cyano; hydroxy; thiol; amino; C 1-6  alkyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, C 3-6  cyclohaloalkyl, C 1-6  alkenyl, haloalkenyl, C 1-6  alkoxy, C 1-6  haloalkoxy, C 1-6  alkylsulfenyl, C 1-6  alkylsulfinyl, C 1-6  alkylsulfonyl, C 1-6  haloalkylsulfenyl, C 1-6  haloalkylsulfinyl, C 1-6  haloalkylsulfonyl, C 1-6  alkylamino, C 2-12  (total carbon number) dialkylamino; most preferably represents chloro, bromo, iodo, fluoro, cyano, amino, C 1-12  alkylamino, C 1-12  haloalkylsulfenyl, C 1-12  haloalkyl; 
             R 1  represents cyano; C 1-12  alkyl, C 3-8  cycloalkyl, C 4-20  (total carbon number) alkyl-cycloalkyl, C 4-20  (total carbon number) cycloalkylalkyl, C 2-12  alkenyl, C 2-12  alkynyl, C 1-12  haloalkyl, or C 3-8  halocycloalkyl; preferably cyano; C 1-6  alkyl, C 3-6  cycloalkyl, C 4-12  (total carbon number) alkylcycloalkyl, C 4-12  (total carbon number) cycloalkylalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 1-6  haloalkyl, or C 3-6  halocycloalkyl; preferably represents C 1-6  haloalkyl, most preferably CF 3 ; 
             m represents 0, 1, 2, 3, 4 or 5; 
             n represents 0, 1, 2 or 3; 
             A represents O, S, CH 2  or N—R 2 ; preferably O; 
             R 2  represents hydrogen; cyano; formyl; C 1-12  alkyl, C 2-12  alkenyl, C 2-12  alkynyl, C 3-8  cycloalkyl, C 4-20  (total carbon number) alkylcycloalkyl, C 4-20  (total carbon number) cycloalkylalkyl, C 1-12  haloalkyl, C 1-12  alkylsulfonyl, C 1-12  haloalkylsulfonyl, phenyl, C 1-12  alkyl-carbonyl, C 1-12  alkoxy-carbonyl, C 1-12  alkylamino-carbonyl, or C 2-24  dialkylamino-carbonyl; preferably represents hydrogen; cyano; formyl; C 1-6  alkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-6  cycloalkyl, C 4-12  (total carbon number) alkylcycloalkyl, C 4-12  (total curbon number) cycloalkylalkyl, C 1-6  haloalkyl, C 1-6  alkylsulfonyl, C 1-6  haloalkylsulfonyl, phenyl, C 1-6  alkyl-carbonyl, C 1-6  alkoxy-carbonyl, C 1-6  alkylamino-carbonyl, or C 2-12  (total carbon number) dialkylamino-carbonyl; 
             W 1 , W 2 , W 3  and W 4  each independently may be omitted to yield a 4- or 5-membered ring, and/or each independently represents a single bond, CH 2 , CH, N, —N + (O − )—, —S(O)—, —S(O) 2 —, —O—S(O)—, O, S, C(R 3 )—R 3 , C—R 3 , C—R 4 , C(R 3 )—R 4 , C(R 4 )—R 4 , C—N(R 3 )—R 3 , C(R 3 )—N(R 3 )—N(R 3 )—R 3 , C—N(R 3 )—N(R 3 )—R 3 , C(R 3 )—N(R 4 )—N(R 3 )—R 3 , C—N(R 4 )—N(R 3 )—R 3 , C(R 3 )—N(R 3 )—OR 3 , C—N(R 3 )—OR 3 , C(R 3 )—OR 3 , C—OR 3 , C(R 3 )—SR 3 , C—SR 3 , C—N 3 , N—R 3 , N—OR 3 , N—N(R 3 )—R 3 , N—R 4 , or C═U under the prerequisite that (i) not more than two of W 1 , W 2 , W 3  and W 4  are simultaneously omitted, and/or (ii) not more than two of W 1 , W 2 , W 3  and W 4  represent O, S, N—R 3  or N—R 4 , C—N(R 3 )—R 3 , C—N(R 3 )—N(R 3 )—R 3 , C—N(R 4 )—N(R 3 )—R 3 , C(R 3 )—N(R 3 )—OR 3 , C—N(R 3 )—OR 3 , C—SR 3 , N—R 3 , N—OR 3  or N—N(R 3 )—R 3  at the same time; and/or (iii) not more than two of W 1 , W 2 , W 3  and W 4  represent C═U at the same time, and/or (iv) if two of W 1 , W 2 , W 3  and W 4  represent O and/or S than least one carbon atom is present between them, and/or (v) when one of W 1 , W 2 , W 3  and W 4  represent CH, N, C—R 3  or C—R 4 , C—N(R 3 )—R 3 , C—N(R 3 )—N(R 3 )—R 3 , C—N(R 4 )—N(R 3 )—R 3 , C—N(R 3 )—OR 3 , C—OR 3 , C—SR 3 , N—R 3 , N—OR 3 , N—N(R 3 )—R 3  a double bond is formed within the condensed ring; and 
             U represents CH 2 , O, S, or N—R 3  or N—R 4 ; 
             R 3  each independently represents hydrogen; hydroxy; thiol; amino; cyano; formyl; halogen; nitro; C 1-6  alkyl, C 2-12  (total carbon number) alkoxyalkyl, C 2-12  (total carbon number) haloalkoxyalkyl, C 2-6  alkenyl, C 2-12  alkynyl, C 3-8  cycloalkyl, C 4-12  (total carbon number) alkylcyclo-alkyl, C 4-12  (total carbon number) cycloalkylalkyl, C 1-6 haloalkyl, C 1-6  alkylcarbonyl, C 1-6  alkyl-carbonyl-C 1-6  alkyl, C 1-6  alkylcarbonyl-C 1-6  alkylcarbonyl, C 1-6 haloalkylcarbonyl, C 1-6  alkoxy-carbonyl, C 1-6  alkylsulfenylcarbonyl, C 1-6 haloalkylsulfenylcarbonyl, aminocarbonyl, C 1-6  alkyl-aminocarbonyl, C 1-6 haloalkylaminocarbonyl, C 1-6  hydroxyalkylaminocarbonyl, C 2-12  (total carbon number) dialkylamino-carbonyl, C 2-6  (total carbon number) di(haloalkyl)aminocarbonyl, C 2-6  alkenylaminocarbonyl, C 2-6  alkynylaminocarbonyl, C 1-6  alkyl-thiocarbonyl, C 3-6  cycloalkyl-carbonyl, C 4-12  (total carbon number) cycloalkylalkyl-carbonyl, C 3-6  cycloalkyl-thiocarbonyl, C 4-12  (total carbon number) cycloalkylalkyl-thiocarbonyl, C 1-6  haloalkyl-thiocarbonyl, C 1-6  alkyl-amino-thiocarbonyl, C 3-6  cycloalkylamino-carbonyl, C 4-12  (total carbon number) cycloalkylalkyl-amino-carbonyl, C 3-6  cycloalkylamino-thiocarbonyl, C 4-12  (total carbon number) cycloalkylalkyl-aminothiocarbonyl, C 1-6 haloalkylamino-thiocarbonyl, C 2-12  (total carbon number) dialkylamino-1-thiocarbonyl, C 3-6  cycloalkyloxy-carbonyl, C 4-12  (total carbon number) cycloalkylalkyl-oxy-carbonyl, C 1-6 haloalkoxy-carbonyl, C 1-6  alkylsulfonyl, C 1-6  haloalkylsulfonyl, phenylsulfonyl, R 4 —C 1-6  alkyl, R 4 -carbonyl, R 4 -thiocarbonyl, R 4 —C 1-6  alkylcarbonyl, R 4 —C 1-6 alkyl-thiocarbonyl, R 4 -oxycarbonyl, R 4 —C 1-6  alkyloxy-carbonyl, R 4 -aminocarbonyl, R 4 -amino-thiocarbonyl, R 4 —C 1-6  alkylamino-carbonyl, or R 4 —C 1-6 alkylamino-thiocarbonyl; and 
             R 4  represents phenyl or 5- or 6-membered saturated or unsaturated heterocyclic ring, preferably is selected among the groups R 4 -1 to R 4 -83 
           
         
       
    
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     wherein
         G represents O, S or N, and wherein each group R 4 -1 to R 4 -83 may be substituted with at least one group selected among hydrogen; halogen; cyano, nitro; C 1-6  alkyl, C 1-6  haloalkyl, C 3-6  cycloalkyl, C 3-6  halocycloalkyl, C 1-6  alkoxy, C 1-6  haloalkoxy, C 1-6  alkylsulfenyl, C 1-6  haloalkyl-sulfenyl, C 1-6  alkylsulfinyl, C 1-6  haloalkylsulfinyl, C 1-6  alkylsulfonyl, C 1-6  haloalkylsulfonyl, C 1-6  alkylamino, C 1-6  haloalkylamino, aminocarbonyl, C 1-6  alkylamino-carbonyl, C 2-12  dialkylamino-carbonyl, C 1-6  alkoxycarbonyl, phenyl, or pyridyl;
 
preferably the group —W 1 —W 2 —W 3 —W 4 — is selected among the 4-5- or 6-membered groups W-1 to W-580
       

     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     wherein
         U represents CH 2 , O, S, N—R 3  or N—R 4 , preferably represents CH 2 , O, S, N—R 3 , N—R 4 , wherein R 3  and R 4  are selected among hydroxy, C 1-6  alkoxy, C 1-6 haloalkoxy, C 1-6 haloalkyl, alkyl C 1-6  alkyl, C 1-6  alkylamino, C 2-12  dialkylamino, pyridin-2-yl-C 1-6 alkyl, pyridin-2-yl-C 1-6 alkoxy, C 1-6 alkylcarbonyl, C 1-6  alkyl-carbonylamino and C 1-6 haloalkylamino.   k stands for 0, 1 or 2,   W′ represents O − , R 3 , OR 3 , SR 3 , NHR 3 , N(R 3 ) 2 , N(R 3 )N(R 3 )R 3 , N(R 4 )N(R 3 )R 3 , N(R 3 )OR 3 , R 4 , NR 4 , or N 3 ;   W′ preferably represents O − , R 3 , OR 3 , SR 3 , NHR 3 , N(R 3 ) 2 , N(R 3 )N(R 3 )R 3 , N(R 4 )N(R 3 )R 3 , N(R 3 )OR 3 , R 4 , NR 4 , or N 3  wherein R 3  and R 4  are selected among hydrogen, formyl, C 1-6  alkyl, C 2-12  alkoxyalkyl, C 2-12  haloalkoxyalkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8  cycloalkyl, C 4-12  alkylcycloalkyl, C 4-12  cycloalkylalkyl, C 1-6 haloalkyl, C 1-6  alklylimino, C 1-6 haloalkylimino, C 1-6 alkenyl-carbonyl, C 1-6 alkynyl-carbonyl, C 1-6  haloalkyl-carbonyl, C 1-6  hydroxyalkyl-carbonyl, C 1-6 alkoxy-carbonyl, C 1-6 haloalkoxy-carbonyl, aminocarbonyl, C 1-6 alkylamino-carbonyl, C 1-6 haloalkylamino-carbonyl, C 1-6  hydroxyalkylamino-carbonyl, C 2-12  dialkylamino-carbonyl, C 2-6  di(haloalkyl)aminocarbonyl, C 2-6 alkenylamino-carbonyl, C 2-6 alkynylamino-carbonyl, C 3-6  cycloalkyl-carbonyl, C 4-12  cycloalkylalkyl-carbonyl, C 3-6  cycloalkylamino-carbonyl, C 4-12  cyclo-alkylalkylamino-carbonyl, C 3-6 cycloalkyloxy-carbonyl, C 4-12  cycloalkylalkyloxy-carbonyl, C 1-6  haloalkoxy-carbonyl, phenyl-C 1-6 alkyl, 2-pyridyl-C 1-6 alkyl, 3-pyridyl-C 1-6 alkyl, 4-pyridyl-1-C 1-6 alkyl, phenylcarbonyl, 2-pyridylcarbonyl, 3-pyridylcarbonyl, 4-pyridylcarbonyl, phenyl-1-C 1-6 alkylcarbonyl, 2-pyridyl-C 1-6 alkylcarbonyl, 3-pyridyl-C 1-6 alkylcarbonyl, 4-pyridyl-C 1-6 alkyl-carbonyl, phenyloxy-carbonyl, 2-pyridyloxy-carbonyl, 3-pyridyloxy-carbonyl, 4-pyridyloxy-carbonyl, phenyl-C 1-6  alkyloxy-carbonyl, 2-pyridyl-C 1-6 alkyloxy-carbonyl, 3-pyridyl-1-C 1-6 alkyloxy-carbonyl, 4-pyridyl-C 1-6  alkyloxy-carbonyl, phenyl-aminocarbonyl, 2-pyridyl-amino-carbonyl, 3-pyridyl-aminocarbonyl, 4-pyridyl-aminocarbonyl, phenyl-C 1-6  alkylamino-carbonyl, 2-pyridyl-C 1-6 alkylamino-carbonyl, 3-pyridyl-C 1-6  alkylamino-carbonyl or 4-pyridyl-C 1-6 alkyl-amino-carbonylcarbonyl, C 1-6 alkylcarbonyl, C 1-6 haloalkylcarbonyl, C 1-6 alkenylcarbonyl, C 1-6  haloalkenylcarbonyl, C 1-6  alkynylcarbonyl, C 1-6 haloalkynylcarbonyl, C 1-6 alkoxycarbonyl, aminocarbonyl, C 1-6 alkylaminocarbonyl, C 1-6 haloalkylaminocarbonyl, C 1-6  hydroxyalkylamino-carbonyl, C 2-12  dialkylamino-carbonyl, C 2-6  di(haloalkyl)aminocarbonyl, C 2-6 alkenylaminocarbonyl, C 2-6  alkynylaminocarbonyl, C 1-6  alkyl-thiocarbonyl, C 3-6  cycloalkylcarbonyl, C 4-12  cycloalkylalkyl-1-carbonyl, C 3-6  cycloalkyl-thiocarbonyl, C 4-12  (total carbon number) cycloalkylalkyl-thiocarbonyl, C 1-6  haloalkyl-thiocarbonyl, C 1-6  alkylamino-thiocarbonyl, C 3-6  cycloalkylamino-carbonyl, C 4-12  cycloalkylalkylamino-carbonyl, C 3-6  cycloalkylamino-thiocarbonyl, C 4-12  cycloalkylalkyl-aminothiocarbonyl, C 1-6  haloalkylamino-thiocarbonyl, C 2-12  dialkylamino-thiocarbonyl, C 3-6  cyclo-alkyloxy-carbonyl, C 4-12  cycloalkylalkyloxy-carbonyl, C 1-6  haloalkoxy-carbonyl, C 1-6 alkylsulfonyl, C 1-6  haloalkylsulfonyl, phenylsulfonyl, phenyl-C 1-6 alkyl, 2-pyridyl-C 1-6 alkyl, 3-pyridyl-C 1-6 alkyl, 4-pyridyl-C 1-6 alkyl, phenylcarbonyl, 2-pyridylcarbonyl, 3-pyridylcarbonyl, 4-pyridylcarbonyl, phenyl-thiocarbonyl, 2-pyridyl-thiocarbonyl, 3-pyridyl-thiocarbonyl, 4-pyridyl-thiocarbonyl, phenyl-C 1-6 alkylcarbonyl, 2-pyridyl-C 1-6 alkylcarbonyl, 3-pyridyl-C 1-6alkyl  carbonyl, 4-pyridyl-1-C 1-6 alkylcarbony, phenyl-C 1-6  alkyl-thiocarbonyl, 2-pyridyl-C 1-6  alkyl-thiocarbonyl, 3-pyridyl-1-C 1-6 alkyl-thiocarbonyl, 4-pyridyl-C 1-6 alkyl-thiocarbonyl, phenyl-oxycarbonyl, 2-pyridyloxycarbonyl, 3-pyridyl-oxycarbonyl, 4-pyridyloxycarbonyl, phenyl-C 1-6  alkyl-oxy-carbonyl, 2-pyridyl-C 1-6 alkyloxy-carbonyl, 3-pyridyl-C 1-6 alkyloxy-carbonyl, 4-pyridyl-1-C 1-6 alkyloxy-carbonyl, phenyl-aminocarbonyl, 2-pyridyl-aminocarbonyl, 3-pyridyl-aminocarbonyl, 4-pyridyl-aminocarbonyl, phenyl-amino-thiocarbonyl, 2-pyridylamino-thiocarbonyl, 3-pyridyl-amino-thiocarbonyl, 4-pyridylamino-thiocarbonyl, phenyl-C 1-6 alkylamino-carbonyl, 2-pyridyl-1-C 1-6 alkylamino-carbonyl, 3-pyridyl-C 1-6  alkylamino-carbonyl, 4-pyridyl-C 1-6 alkylamino-carbonyl, phenyl-C 1-6  alkylaminothiocarbonyl, 2-pyridyl-C 1-6  alkylamino-thiocarbonyl, 3-pyridyl-C 1-6 alkyl-amino-thiocarbonyl or 4-pyridyl-C 1-6 alkylamino-thiocarbonyl, preferably R 3  and R 4  are selected among hydrogen, formyl, C 1-6  hydroxyalkyl-carbonyl, C 1-6 alkoxy-carbonyl, C 1-6 alkylamino-1-carbonyl, C 1-6 haloalkylamino-carbonyl, C 2-12  dialkylamino-carbonyl, C 1-6 alkylcarbonyl, C 1-6 haloalkylcarbonyl, C 1-6  alkyl-thiocarbonyl, C 1-6  alkylamino-thiocarbonyl, C 1-6  alkylsulfonyl, pyrimidinyl, and pyridyl.       

     The present invention does not include the following compounds, which are known from WO 2005/085216, namely 
     (i) compounds of formula (I), wherein the group (X) m -Q stands for 3,5-dichlorophenyl, n stands for 0, A is oxygen, R 1  stands for CF 3 , and the group —W 1 —W 2 —W 3 —W 4 — stands for the group W-376 with U standing for oxygen and wherein W′ which is bound to the nitrogen atom adjacent to the carbonyl group either represents hydrogen or CH 2 -2-pyridyl; and
 
(ii) compounds of formula (I), wherein the group (X) m -Q stands for 3,5-dichlorophenyl, n stands for 0, A is oxygen, R 1  stands for CF 3 , and the group —W 1 —W 2 —W 3 —W 4 — stands for the group W-23 with U standing for oxygen and wherein W which is bound to the nitrogen atom is either hydrogen, methyl or CH 2 -2-pyridyl; and
 
(iii) compounds of formula (I), wherein the group (X) m -Q stands for 3,5-dichlorophenyl, n stands for 0, A is oxygen, R 1  stands for CF 3 , and wherein W 1  is omitted, W 2  stands for a group C═CH 2 , W 3  stands for N—CH 2 —CF 3  and W 4  stands for a group C═O.
 
     In another aspect, the invention is directed to compounds of formula (I) wherein
         X represents halogen, C 1-12  alkyl, C 1-12  haloalkyl, nitro, cyano, C 1-12  alkoxy, C 1-12  haloalkoxy, C 1-12  alkylthio, C 1-12  alkylsulfinyl, C 1-12  alkylsulfonyl, C 1-12  haloalkylthio, C 1-12  haloalkylsulfinyl, C 1-12  haloalkylsulfonyl, hydroxy, mercapto, amino, C 1-12  alkylamino, C 2-24  (total carbon number) dialkylamino, C 1-12  (total carbon number) acylamino, C 1-12  alkoxy-carbonyl-amino, C 1-12  haloalkoxy-carbonylamino, C 1-12  alkyl-sulfonylamino group, or C 1-12  haloalkyl-1-sulfonylamino;   Q represents a group selected among Q-1 to Q-54;   Y represents halogen, C 1-12  alkyl, C 1-12  haloalkyl, C 3-12  cycloalkyl, C 3-12  cyclo-haloalkyl, nitro, cyano, C 2-12  alkenyl, C 2-12  haloalkenyl, C 1-12  alkoxy, C 1-12  haloalkoxy, C 1-12 alkylthio, C 1-12  alkylsulfinyl, C 1-12 alkylsulfonyl, C 1-12  haloalkylthio, C 1-12  haloalkylsulfinyl, C 1-12  haloalkyl-sulfonyl, hydroxy, mercapto, amino, C 1-12  alkylamino, C 2-24  (total carbon number) dialkylamino, aminocarbonyl, C 1-12  alkylaminocarbonyl, C 2-24  (total carbon number) dialkylaminocarbonyl, C 2-12  (total carbon number) acylamino, C 1-12  alkoxy-carbonylamino benzyloxy-carbonylamino C 1-12 haloalkoxy-carbonylamino, C 1-12 alkylsulfonylamino, C 1-12  haloalkylsulfonylamino or C 3-26  (total carbon number) trialkylsilyl;   R 1  represents C 1-12  alkyl, C 3-12  (total carbon number) cycloalkyl, C 4-12  (total carbon number) alkylcycloalkyl, C 4-12  (total carbon number) cycloalkylalkyl, C 2-12  alkenyl, C 2-12  alkynyl, C 1-12  haloalkyl, C 3-12  (total carbon number) halocycloalkyl, or cyano;   m represents 0, 1, 2, 3, 4 or 5;   n represents 0, 1, 2 or 3;   A represents O, CH 2  or N—R x ,   R x  independently represents hydrogen, cyano, formyl, C 1-12  alkyl, C 2-12  alkenyl, C 2-12  alkynyl, C 3-12  (total carbon number) cycloalkyl, C 4-12  (total carbon number) alkylcycloalkyl, C 4-12  (total carbon number) cycloalkylalkyl, C 1-12  haloalkyl, phenyl, C 1-12  alkyl-carbonyl, C 1-12  alkoxy-carbonyl, C 1-12  alkyl-aminocarbonyl, C 2-24  (total carbon number) dialkyl-amino-carbonyl;   W 1 , W 2 , W 3  and W 4  independently represents a single bond, CH 2 , CH, N, CH—R x , C(R x ) 2 , C═U, O, S, N—R y  or N—R z  under the prerequisite that a) two or more of W 1 , W 2 , W 3  and W 4  are not simultaneously a single bond, b) three or more of W 1 , W 2 , W 3  and W 4  are not simultaneously O, S or N—R y , c) three or more of W 1 , W 2 , W 3  and W 4  are not simultaneously C=U, d) when two of W 1 , W 2 , W 3  and W 4  simultaneously represent O and/or S, at least one carbon atom is present between them, and, e) when at least one of W 1 , W 2 , W 3  and W 4  is CH or N, at least one of adjacent W 1 , W 2 , W 3  and W 4  is CH or N and forms a double bond.
 
U represents CH 2 , O, S, N—R y  or N—R z ;
   R y  independently represents hydrogen, hydroxy, amino, C 1-12  alkyl, C 2-12  alkenyl, C 2-12  alkenyloxy, C 2-12  alkynyl, C 2-12  alkynyloxy, C 3-12  cycloalkyl, C 4-12  (total carbon number) alkyl-cycloalkyl, C 4-12  (total carbon number) cycloalkylalkyl, C 1-12  haloalkyl, C 1-12  alkylamino, C 2-24  (total carbon number) dialkyl-amino, C 1-12  alkoxy, C 1-12  haloalkoxy, formyl, C 1-12  alkyl-carbonyl, C 1-12  haloalkyl-carbonyl, C 1-12  alkyl-carbonylamino, C 1-12  haloalkyl-carbonylamino, C 1-12  alkyl-sulfonyl, C 1-12  haloalkyl-sulfonyl, phenylsulfonyl, and said substituents other than hydrogen and a formyl group may be substituted with R z ;   R z  is selected among the groups R 4 -1 to R 4 -83 wherein G represents O, S or N, and which may be substituted with at least one group selected among hydrogen, halogen, C 1-12  alkyl C 1-12  haloalkyl, C 3-12  cycloalkyl, C 3-12  halocycloalkyl, C 1-12  alkoxy, C 1-12  haloalkoxy, C 1-12  alkylthio, C 1-12  haloalkylthio, C 1-12  alkylsulfinyl, C 1-12  haloalkylsulfinyl, C 1-12  alkylsulfonyl, C 1-12  haloalkyl-sulfonyl, C 1-12  alkylamino, C 1-12  haloalkylamino, cyano, nitro, aminocarbonyl, C 1-12  alkyl-amino-carbonyl, C 2-24  (total carbon number) dialkyl-aminocarbonyl, C 1-12  alkoxy-carbonyl phenyl or pyridyl;       

     In a further aspect, the invention is also directed to compounds of formula (I) wherein
         X independently represents halogen, C 1-12  alkyl, C 1-12  haloalkyl, nitro, cyano, C 1-12  alkoxy, C 1-12  haloalkoxy, C 1-12  alkylthio, C 1-12  alkylsulfinyl, C 1-12  alkylsulfonyl, C 1-12  haloalkyl-thio, C 1-12  haloalkylsulfinyl, C 1-12  haloalkylsulfonyl, hydroxy, mercapto, amino, C 1-12  alkylamino, C 2-24  (total carbon number), dialkylamino, C 1-12  (total carbon number) acylamino, C 2-13  (total carbon number) alkoxy-carbonylamino, C 2-13  (total carbon number) haloalkoxy-carbonylamino, C 1-12  alkyl-sulfonylamino, a C 1-12  haloalkylsulfonylamino;   Q is selected among Q-1 to Q-54;   Y independently represents halogen, C 1-12  alkyl, C 1-12  haloalkyl, C 3-12  cycloalkyl, C 3-12  cyclohaloalkyl, nitro, cyano, C 2-12  alkenyl, C 2-12  haloalkenyl, C 1-12  alkoxy, C 1-12  haloalkoxy, C 1-12  alkylthio, C 1-12  alkylsulfinyl, C 1-12 alkylsulfonyl, C 1-12  haloalkylthio, C 1-12  haloalkylsulfinyl, C 1-12  haloalkylsulfonyl, hydroxy, mercapto, amino, C 1-12  alkylamino, C 2-24  (total carbon number) dialkylamino, aminocarbonyl, C 2-13  (total carbon number) alkylaminocarbonyl, C 3-25  (total carbon number) dialkylaminocarbonyl, C 1-12  (total carbon number) acylamino, C 2-13  (total carbon number) alkoxy-carbonylamino, benzyloxy-carbonylamino, C 2-13  haloalkoxy-carbonylamino, C 1-12  alkyl-sulfonylamino, C 1-12  haloalkylsulfonylamino, a C 3-26  (total carbon number) trialkylsilyl;   R 1  represents C 1-12  alkyl, C 3-12  (total carbon number) cycloalkyl, C 4-24  (total carbon number) alkylcycloalkyl, C 4-24  (total carbon number) cycloalkylalkyl, C 2-12  alkenyl, C 2-12  alkynyl, C 1-12  haloalkyl, C 3-12  (total carbon number) halocycloalkyl, cyano;   m represents 0, 1, 2, 3, 4 or 5,   n represents 0, 1, 2 or 3,   A represents O, CH 2  or N—R x ;   R x  independently represents hydrogen, cyano, formyl, C 1-12  alkyl, C 2-12  alkenyl, C 2-12  alkynyl, C 3-12  (total carbon number) cycloalkyl, C 4-12  (total carbon number) alkylcycloalkyl, C 4-24  (total carbon number) cycloalkylalkyl, C 1-12  haloalkyl, phenyl, C 2-13  (total carbon number) alkylcarbonyl, C 2-13  (total carbon number) alkoxycarbonyl, C 2-13  (total carbon number) alkylamino-carbonyl or C 3-25  (total carbon number) dialkylaminocarbonyl,   W 1 , W 2 , W 3  and W 4  independently represent a single bond, CH 2 , CH, N, O, S, CH—R y , C—R y , C(R y ) 2 , N—R z , CH—R xx , C—R xx  or C═U; under the prerequisite that a) two or more of W 1 , W 2 , W 3  and W 4  are not simultaneously a single bond, b) three or more of W 1 , W 2 , W 3  and W 4  are not simultaneously O, S, N—R z  or N—R xx , c) three or more of W 1 , W 2 , W 3  and W 4  are not simultaneously C═U, d) when two of W 1 , W 2 , W 3  and W 4  simultaneously represent O and/or S, at least one carbon atom is present between them, and, e) when one of W 1 , W 2 , W 3  and W 4  is CH, N, C—R y  or C—R xx , a double bond is formed within the condensed ring;   R Y  independently represents hydroxy, amino, cyano, formyl, halogen, nitro, C 1-12  alkyl, C 2-12  alkenyl, C 2-12  alkynyl, C 3-12  cycloalkyl, C 4-24  alkylcycloalkyl, C 4-24  cycloalkylalkyl, C 1-12  haloalkyl, C 2-13  (total carbon number) alkylcarbonyl, C 2-13  (total carbon number) alkoxycarbonyl, C 2-13  (total carbon number) alkylaminocarbonyl, C 3-13  (total carbon number) dialkylaminocarbonyl, C 2-13  (total carbon number) alkyl-carbonylamino, C 2-13  (total carbon number) alkylthiocarbonylamino, C 4-13  (total carbon number) cycloalkyl-carbonylamino, C 5-25  (total carbon number) cycloalkylalkyl-carbonylamino, C 4-13  (total carbon number) cycloalkyl-thiocarbonylamino, C 5-25  (total carbon number) cycloalkylalkylthiocarbonylamino, C 2-13  (total carbon number) haloalkyl-carbonylamino, C 2-13  (total carbon number) haloalkylthiocarbonylamino, C 2-13  (total carbon number) alkylamino-carbonylamino, C 2-13  (total carbon number) alkylamino-thiocarbonylamino, C 4-13  (total carbon number) cycloalkylamino-carbonylamino, C 5-25  (total carbon number) cycloalkylalkylamino-carbonylamino, C 4-13  (total carbon number) cycloalkylamino-thiocarbonylamino, C 5-25  (total carbon number) cycloalkylalkylaminothiocarbonylamino, C 2-13  (total carbon number) haloalkylamino-carbonylamino, C 2-13  (total carbon number) haloalkylamino-thiocarbonylamino, C 3-25  (total carbon number) dialkylamino-carbonylamino, C 2-25  (total carbon number) dialkylaminothiocarbonylamino, C 2-13  (total carbon number) alkylaminocarbonyloxy, C 2-13  (total carbon number) alkylaminocarbonylthio, C 4-13  (total carbon number) cycloalkylamino-carbonyloxy, C 5-25  (total carbon number) cycloalkylalkylaminocarbonyloxy, C 4-13  (total carbon number) cycloalkylaminocarbonylthio, C 5-25  (total carbon number) cycloalkylalkylaminocarbonyl-thio, C 2-13  (total carbon number) haloalkylaminocarbonyloxy, C 2-13  (total carbon number) haloalkyl-aminocarbonylthio, C 3-25  (total carbon number) dialkylaminocarbonyloxy, C 3-25  (total carbon number) dialkylaminocarbonylthio, C 2-13  (total carbon number) alkoxy-carbonylamino, C 4-13  (total carbon number) cycloalkyloxy-carbonylamino, C 5-25  (total carbon number) cycloalkylalkyl-oxy-carbonylamino, C 2-13  (total carbon number) haloalkoxy-carbonylamino, C 1-12  alkyl-sulfonylamino, C 1-12 haloalkylsulfonylamino, and said substituents other than cyano, formyl, halogen and nitro may be substituted with R xx ;   U represents CH 2 , O, S, N—R z  or N—R xx ;   R z  represents hydrogen, hydroxy, amino, C 1-12  alkyl, C 1-12  haloalkyl, C 2-12  alkenyl, C 2-12  alkenyloxy, C 2-12  alkynyl, C 2-12  alkynyloxy, C 3-12  cycloalkyl, C 4-24  alkylcycloalkyl, C 4-24  cyclo-alkylalkyl, C 1-12  alkylamino, C 2-24  (total carbon number) dialkylamino, C 1-12  alkoxy, C 1-12  haloalkoxy, formyl group, a C 2-13  (total carbon number) alkylcarbonyl, C 2-13  (total carbon number) haloalkylcarbonyl, C 2-13  (total carbon number) alkoxycarbonyl, C 2-13  (total carbon number) alkylaminocarbonyl, C 2-13  (total carbon number) alkyl-carbonylamino, C 2-13  (total carbon number) haloalkyl-carbonylamino, C 2-13  (total carbon number) alkoxy-carbonylamino, C 2-13  (total carbon number) alkylamino-carbonylamino, C 1-12  (total carbon number) alkylsulfonyl, C 1-12  (total carbon number) haloalkylsulfonyl, phenylsulfonyl, C 2-13  (total carbon number) alkylaminocarbonyl group which may be substituted or a C 2-13  (total carbon number) haloalkylaminocarbonyl, and said substituents other than hydrogen and formyl may be substituted with R xx ;   R xx  is selected among the groups R 4 -1 to R 4 -83 wherein G represents O, S or N, and which may be substituted with at least one group selected among hydrogen, halogen, C 1-12  alkyl, C 1-12  haloalkyl, C 3-12  cycloalkyl, C 3-12  halocycloalkyl, C 1-12  alkoxy, C 1-12  haloalkoxy, C 1-12  alkylthio, C 1-12  haloalkylthio, C 1-12  alkylsulfinyl, C 1-12  haloalkylsulfinyl, C 1-12  alkylsulfonyl, C 1-12  haloalkyl-sulfonyl, C 1-12  alkylamino, C 1-12  haloalkylamino, cyano, nitro, aminocarbonyl, C 1-12  alkyl-amino-carbonyl, C 2-24  (total carbon number) dialkyl-aminocarbonyl, C 1-12  alkoxy-carbonyl phenyl or pyridyl.       

     The compounds according to the invention have asymmetric carbons, and thus the compounds also include optically active species. Moreover, the present invention also includes N-oxides and salts of the compounds according to the invention. 
     The present application is further directed to the following embodiments: 
     Embodiment A: Compounds having the structure (I-a-1) or (I-a-2), wherein the chemical groups A, R 1 , W 1 , W 2 , W 3  and W 4  are as defined herein, and wherein each X 1 , X 2  and X 3  are as defined herein for X, and wherein each Y 1 , Y 2  and Y 3  are as defined herein for Y. 
     
       
         
         
             
             
         
       
     
     Embodiment B: Compounds as defined in embodiment A, wherein the group —W 1 —W 2 —W 3 —W 4 —is selected among W-5, W-8, W-12, W-16, W-17, W-18, W-20, W-22, W-23, W-24, W-30, W-31, W-33, W-38, W-39, W-40, W-41, W-42, W-44, W-45, W-46, W-53, W-54, W-64, W-76, W-79, W-86, W-98, W-99, W-114, W-115, W-134, W-157, W-161, W-173, W-223, W-224, W-225, W-241, W-315, W-337, W-339, W-344, W-345, W-348, W-351 and W-357, preferably W-5, W-7, W-11, W-16, W-17, W-20, W-39, W-44, W-45, W-134, W-138, W-158, W-161, W-222, W-225, W-315, W-337, W-340, W-351 and W-357, more preferably W-5 and W-134, or W-16 and W-39. 
     Embodiment C: Compounds as defined in embodiment A or B, wherein A represents oxygen or CH 2 , R 1  represents CF 3 , and/or X 1 , X 2 , X 3  are independently selected among hydrogen, halogen, amino, C 1-6  alkylamino, C 2-12  dialkylamino, nitro, C 1-6 alkoxy, and C 1-6 haloalkyl and Y 1 , Y 2 , Y 3  is H. 
     Embodiment D: Compounds having the structure (I-d-1), wherein the chemical groups A, R 1 , Q, X, Y, m, n and W′ are as defined herein and wherein W″ is selected among hydrogen, halogen, hydroxy, thiol, cyano, C 1-6  alkyl, C 1-6 haloalkyl, C 1-6  alkoxy, C 1-6 alkylsulfenyl, C 1-6  alkylsulfinyl, C 1-6  alkylsulfonyl. 
     
       
         
         
             
             
         
       
     
     Embodiment D1: Compounds as defined in embodiment D, wherein the group Q is selected among Q-1, Q-2, Q-42 to Q-54 and X is independently selected among hydrogen, halogen, amino, C 1-6  alkylamino, C 2-12  dialkylamino, nitro, C 1-6  alkoxy, and C 1-6 haloalkyl. 
     Embodiment D2: Compounds as defined in embodiment D or D1, wherein A represents oxygen or CH 2 , R 1  represents CF 3 , and Y is H. 
     In these embodiments, W′ preferably represents amino, hydroxy, carbonylamino C 1-6  alkyl-carbonylamino, C 1-6 alkylcarbonyl-C 1-6 alkyl-carbonylamino, C 1-6  alkylsulfenyl-C 1-6  alkyl-carbonylamino, C 1-6 alkylsulfenyl-C 1-6 alkyl-carbonylamino, C 1-6  alkylsulfinyl-C 1-6 alkyl-carbonyl-amino, C 1-6  alkylsulfonyl-C 1-6 alkyl-carbonylamino, C 1-6 haloalkyl-carbonylamino, cyano-C 1-6  alkyl-carbonylamino C 1-6  alkenyl-carbonylamino, C 1-6 haloalkenyl-carbonylamino, C 1-6  alkynyl-carbonylamino, C 1-6 haloalkynyl-carbonylamino, C 1-6  alkoxy-carbonylamino, C 1-6 haloalkoxy-carbonylamino, cyano-C 1-6  alkoxy-carbonylamino, C 1-6 alkoxy-C 1-6 alkylamino-carbonylamino, C 1-6  alkoxy-C 1-6  alkoxy-carbonylamino, amino-carbonylamino, C 1-6  alkylamino-carbonylamino, C 1-6 haloalkylamino-carbonylamino, hydroxyC 1-6 alkylamino-carbonylamino, cyano-C 1-6  alkyl-amino-carbonylamino, C 2-12  dialkylamino-carbonylamino, C 2-12  dialkylamino-C 1-6  alkyl-carbonyl-amino, C 2-6  di(haloalkyl)amino-carbonylamino, C 2-6  alkenylamino-carbonylamino, C 2-6  alkynyl-amino-carbonylamino, C 1-6  alkoxy-amino-carbonylamino, C 1-6  alkylsulfonylamino, C 1-6  alkenyl-oxy-amino-carbonylamino, C 1-6 alkyl-thiocarbonylamino, C 3-6  cycloalkyl-carbonylamino, C 3-6  halocycloalkyl-carbonylamino, C 4-12  cycloalkylalkyl-carbonylamino, C 3-6  cycloalkyl-thiocarbonylamino, C 4-12  cycloalkylalkyl-thiocarbonylamino, C 1-6 haloalkyl-thiocarbonylamino, C 1-6  alkylamino-thiocarbonylamino, C 3-6  cycloalkylamino-carbonylamino, C 3-6  halocycloalkyl-amino-carbonylamino, C 4-12  cycloalkylalkylamino-carbonylamino, C 3-6  cycloalkylamino-thio-carbonylamino, C 4-12  cycloalkylalkylaminothiocarbonylamino, C 1-6  haloalkylamino-thiocarbonyl-amino, C 2-12  dialkylamino-thiocarbonylamino, C 3-6  cycloalkyloxy-carbonylamino, C 4-12  cycloalkyl-alkyloxy-carbonylamino, C 1-6  haloalkoxy-carbonylamino, C 1-6  alkylsulfonylamino, C 1-6 haloalkyl-sulfonylamino, C 1-6 alkylsulfonylamino, phenylsulfonylamino, phenyl-C 1-6 alkylamino, 2-pyridyl-C 1-6  alkylamino, 3-pyridyl-C 1-6  alkylamino, 4-pyridyl-C 1-6  alkylamino, phenyl-carbonylamino, halo-phenyl-carbonylamino, azetidine-1-yl-carbonylamino, pyrrolidine-1-yl-carbonylamino, N-methyl-pyrrolidine-2-yl-carbonylamino, furan-2-yl-carbonylamino, trifluoromethylphenyl-carbonylamino, phenylamino-carbonylamino, halophenylamino-carbonylamino, trifluoromethyl-phenylamino-carbonylamino, 2-pyridyl-carbonylamino, 3-pyridyl-carbonylamino, 4-pyridyl-carbonylamino, phenyl-thiocarbonylamino, 2-pyridyl-thiocarbonylamino, 3-pyridyl-thiocarbonyl-amino, 4-pyridyl-thiocarbonylamino, phenyl-C 1-6  alkyl-carbonylamino, 2-pyridyl-C 1-6  alkyl-carbonylamino, 3-pyridyl-C 1-6 alkylcarbonyl, 4-pyridyl-C 1-6 alkylcarbony, phenyl-C 1-6  alkyl-thiocarbonyl, 2-pyridyl-C 1-6  alkyl-thiocarbonyl, 3-pyridyl-C 1-6 alkyl-thiocarbonylamino, 4-pyridyl-C 1-6  alkyl-thiocarbonylamino, phenyl-oxy-carbonylamino, 2-pyridyloxy-carbonylamino, 3-pyridyloxy-carbonylamino, 4-pyridyloxy-carbonylamino, phenyl-C 1-6  alkyloxy-carbonylamino, 2-pyridyl-C 1-6 alkyloxy-carbonylamino, 3-pyridyl-C 1-6  alkyloxy-carbonylamino, 4-pyridyl-C 1-6  alkyloxy-carbonylamino, phenyl-amino-carbonylamino, 2-pyridyl-amino-carbonylamino, 3-pyridyl-amino-carbonylamino, 4-pyridyl-amino-carbonylamino, phenyl-amino-thiocarbonyl-amino, 2-pyridylamino-thiocarbonylamino, 3-pyridylamino-thiocarbonylamino, 4-pyridylamino-thiocarbonylamino, phenyl-C 1-6  alkylamino-carbonylamino, 2-pyridyl-C 1-6 alkylamino-carbonyl-amino, 3-pydidyl-C 1-6 alkylamino-carbonylamino, 4-pyridyl-C 1-6 alkylamino-carbonylamino, phenyl-C 1-6  alkylamino-thiocarbonylamino, 2-pyridyl-C 1-6 alkylamino-thiocarbonylamino, 3-pydidyl-C 1-6 alkylamino-thiocarbonylamino or 4-pyridyl-C 1-6 alkylamino-thiocarbonylamino, 1,2,3-triazole-4-trimethylsilyl-1-yl, 1,2,3-triazole-1-yl, succinimide-1-yl, —N 3 , phthalimide-2-yl, C 1-6  alkylcarbonyloxy, more preferably represents amino, hydroxy, carbonylamino, C 1-6  alkyl-sulfonylamino, C 1-6  alkylamino-carbonylamino, C 1-6  alkylthiocarbonylamino, C 1-6  alkyl-carbonyl-amino, C 1-6  alkylcarbonyl-C 1-6  alkyl-carbonylamino, C 1-6  alkylsulfenyl-C 1-6  alkyl-carbonylamino, C 1-6  alkylsulfenyl-C 1-6  alkyl-carbonylamino, C 1-6  alkylsulfinyl-C 1-6  alkyl-carbonylamino, C 1-6  alkyl-sulfonyl-C 1-6  alkyl-carbonylamino, C 1-6 haloalkyl-carbonylamino, cyano-C 1-6 alkyl-carbonylamino C 1-6  alkenyl-carbonylamino, C 1-6  alkynyl-carbonylamino, C 1-6  alkoxy-carbonylamino, C 1-6  haloalkoxy-carbonylamino, cyano-C 1-6 alkoxy-carbonylamino, C 1-6  alkoxy-C 1-6  alkylamino-carbonylamino, C 1-6  alkoxy-C 1-6  alkoxy-carbonylamino, amino-carbonylamino, C 1-6  alkylamino-carbonylamino, C 1-6  haloalkylamino-carbonylamino, hydroxyC 1-6 alkylamino-carbonylamino, cyano-C 1-6  alkylamino-carbonylamino, C 2-12  dialkylamino-carbonylamino, C 2-12  dialkylamino-C 1-6  alkyl-carbonylamino, C 2-6  alkynylamino-carbonylamino, C 2-6  alkenylamino-carbonylamino, C 1-6  alkoxy-amino-carbonylamino, C 1-6  alkenyloxy-amino-carbonylamino, C 3-6  cycloalkyl-carbonyl-amino, C 3-6 halocycloalkyl-carbonylamino, C 4-12  cycloalkylalkyl-carbonylamino, C 1-6  alkylamino-thiocarbonylamino, C 3-6  cycloalkylamino-carbonylamino, C 3-6 halocycloalkylamino-carbonyl-amino, C 4-12  cycloalkylalkylamino-carbonylamino, C 1-6  haloalkylsulfonylamino, phenyl-carbonyl-amino, halo-phenyl-carbonylamino, azetidine-1-yl-carbonylamino, pyrrolidine-1-yl-carbonylamino, N-methyl-pyrrolidine-2-yl-carbonylamino, furan-2-yl-carbonylamino, trifluoromethylphenyl-carbonylamino, phenylamino-carbonylamino, halophenylamino-carbonylamino, trifluoromethyl-phenylamino-carbonylamino, 1,2,3-triazole-4-trimethylsilyl-1-yl, 1,2,3-triazole-1-yl, succinimide-1-yl, —N 3 , phthalimide-2-yl, C 1-6  alkylcarbonyloxy, most preferably represents C 1-6  haloalkyl-carbonylamino, C 1-6  alkylamino-carbonylamino, C 1-6  haloalkylamino-carbonylamino, C 1-6  alkylamino-carbonylamino, C 1-6  alkyl-carbonylamino, and C 1-6  haloalkylamino-carbonylamino. 
     Embodiment E: Compounds having the structure (I-e-1), wherein the chemical groups A, R 1 , Q, X, Y, m, n, and W′ are as defined herein and wherein W″ is selected among hydrogen, halogen, hydroxy, thiol, cyano, C 1-6  alkyl, C 1-6 haloalkyl, C 1-6  alkoxy, C 1-6 alkylsulfenyl, C 1-6  alkylsulfinyl, C 1-6 alkylsulfonyl. 
     
       
         
         
             
             
         
       
     
     Embodiment E1: Compounds as defined in embodiment E, wherein the group Q is selected among Q-1, Q-2, Q-42 to Q-54 and X is independently selected among hydrogen, halogen, amino, C 1-6  alkylamino, C 2-12  dialkylamino, nitro, C 1-6  alkoxy, and C 1-6  haloalkyl. 
     Embodiment E2: Compounds as defined in embodiment E or E1, wherein A represents oxygen or CH 2 , R 1  represents CF 3 , and Y is H. 
     In these embodiments, W′ preferably represents hydrogen, C 1-6  alky, C 1-6 haloalky, C 1-6  alkyl-carbonyl, C 1-6  haloalkylcarbonyl, C 1-6 alkenylcarbonyl, C 1-6  haloalkenylcarbonyl, C 1-6  alkynyl-carbonyl, C 1-6 haloalkynylcarbonyl, C 1-6 alkoxycarbonyl, aminocarbonyl, C 1-6  alkylaminocarbonyl, C 1-6 haloalkylaminocarbonyl, C 1-6  hydroxyalkylaminocarbonyl, C 2-12  dialkylamino-carbonyl, C 2-6  di(haloalkyl)aminocarbonyl, C 2-6  alkenylaminocarbonyl, C 2-6  alkynylaminocarbonyl, phenyaminocarbonyl, halophenylaminocarbonyl, C 1-6  alkyl-thiocarbonyl, C 3-6  cycloalkylcarbonyl, C 4-12  cycloalkylalkyl-carbonyl, C 3-6  cycloalkyl-thiocarbonyl, C 4-12  cycloalkylalkyl-thiocarbonyl, C 1-6 haloalkyl-thiocarbonyl, C 1-6  alkylamino-thiocarbonyl, C 3-6  cycloalkylamino-carbonyl, C 4-12  cycloalkylalkylamino-carbonyl, C 3-6  cycloalkylamino-thiocarbonyl, C 4-12  cycloalkylalkyl-aminothiocarbonyl, C 1-6 haloalkylamino-thiocarbonyl, C 2-12  dialkylamino-thiocarbonyl, C 3-6  cyclo-alkyloxy-carbonyl, C 4-12  cycloalkylalkyloxy-carbonyl, C 1-6 haloalkoxy-carbonyl, C 1-6 alkylsulfonyl, C 1-6  haloalkylsulfonyl, phenylsulfonyl, phenyl-C 1-6  alkyl, pyridin-2-yl-C 1-6  alkyl, 3-pyridyl-C 1-6  alkyl, 4-pyridyl-C 1-6  alkyl, phenylcarbonyl, 2-pyridylcarbonyl, 3-pyridylcarbonyl, 4-pyridyl-carbonyl, phenyl-thiocarbonyl, 2-pyridyl-thiocarbonyl, 3-pyridyl-thiocarbonyl, 4-pyridyl-thiocarbonyl, phenyl-C 1-6  alkylcarbonyl, 2-pyridyl-C 1-6 alkylcarbonyl, 3-pyridyl-C 1-6  alkylcarbonyl, 4-pyridyl-C 1-6  alkylcarbonyl, phenyl-C 1-6 alkyl-thiocarbonyl, 2-pyridyl-C 1-6 alkyl-thiocarbonyl, 3-pyridyl-C 1-6 alkyl-thiocarbonyl, 4-pyridyl-C 1-6 alkyl-thiocarbonyl, phenyl-oxycarbonyl, 2-pyridyloxycarbonyl, 3-pyridyl-oxycarbonyl, 4-pyridyloxycarbonyl, phenyl-C 1-6  alkyl-oxy-carbonyl, 2-pyridyl-C 1-6  alkyloxy-carbonyl, 3-pyridyl-C 1-6 alkyloxy-carbonyl, 4-pyridyl-C 1-6  alkyloxy-carbonyl, phenyl-aminocarbonyl, 2-pyridyl-aminocarbonyl, 3-pyridyl-amino-carbonyl, 4-pyridyl-aminocarbonyl, phenyl-amino-thiocarbonyl, 2-pyridylamino-thiocarbonyl, 3-pyridylamino-thiocarbonyl, 4-pyridylamino-thiocarbonyl, phenyl-C 1-6  alkylamino-carbonyl, halophenyl-C 1-6 alkylamino-carbonyl, pyridin-2-yl-C 1-6 alkylamino-carbonyl, 3-pyridyl-C 1-6  alkyl-amino-carbonyl, 4-pyridyl-C 1-6  alkylamino-carbonyl, phenyl-C 1-6 alkylamino-thiocarbonyl, 2-pyridyl-C 1-6 alkylamino-thiocarbonyl, 3-pyridyl-C 1-6 alkylamino-thiocarbonyl or 4-pyridyl-C 1-6  alkylamino-thiocarbonyl, more preferably represents hydrogen, C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkylcarbonyl, C 1-6 haloalkylcarbonyl, C 1-6 alkoxycarbonylC 1-6 alkylaminocarbonyl, C 1-6  haloalkylaminocarbonyl, C 2-12  dialkylaminocarbonyl, C 2-6  alkenylaminocarbonyl, C 2-6  alkynyl-aminocarbonyl, phenylaminocarbonyl, halophenylaminocarbonyl, C 1-6  alkylamino-thiocarbonyl, C 3-6  cycloalkylamino-carbonyl, C 4-12  cycloalkylalkylamino-carbonyl, phenyl-C 1-6  alkyl, pyridin-2-yl-C 1-6  alkyl, phenyl-C 1-6  alkylamino-carbonyl, halophenyl-C 1-6  alkylamino-carbonyl, pyridin-2-yl-C 1-6 alkylamino-carbonyl. 
     Embodiment F: Compounds having the structure (I-f-1), wherein the chemical groups A, R 1 , Q, X, Y, m, n, and W′ are as defined herein and wherein W″ is selected among hydrogen, halogen, hydroxy, thiol, cyano, C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  alkylsulfenyl, C 1-6  alkylsulfinyl, C 1-6 alkylsulfonyl. 
     
       
         
         
             
             
         
       
     
     Embodiment F1: Compounds as defined in embodiment F, wherein the group Q is selected among Q-1, Q-2, Q-42 to Q-54 and X is independently selected among hydrogen, halogen, amino, C 1-6  alkylamino, C 2-12  dialkylamino, nitro, C 1-6  alkoxy, and C 1-6  haloalkyl. 
     Embodiment F2: Compounds as defined in embodiment F or F1, wherein A represents oxygen or CH 2 , R 1  represents CF 3 , and/or Y is H. 
     In these embodiments, W′ preferably represents amino, hydroxy, carbonylamino, C 1-6  alkyl-carbonylamino, C 1-6  alkylcarbonyl-C 1-6  alkyl-carbonylamino, C 1-6  alkylsulfenyl-C 1-6 alkyl-carbonyl-amino, C 1-6 alkylsulfenyl-C 1-6 alkyl-carbonylamino, C 1-6  alkylsulfinyl-C 1-6 alkyl-carbonylamino, C 1-6  alkylsulfonyl-C 1-6  alkyl-carbonylamino, C 1-6  haloalkyl-carbonylamino, cyano-C 1-6  alkyl-carbonylamino C 1-6  alkenyl-carbonylamino, C 1-6 haloalkenyl-carbonylamino, C 1-6  alkynyl-carbonylamino, C 1-6  haloalkynyl-carbonylamino, C 1-6  alkoxy-carbonylamino, C 1-6 haloalkoxy-carbonylamino, cyano-C 1-6  alkoxy-carbonylamino, C 1-6  alkoxy-C 1-6  alkylamino-carbonylamino, C 1-6  alkoxy-C 1-6  alkoxy-carbonylamino, amino-carbonylamino, C 1-6  alkylamino-carbonylamino, C 1-6  haloalkylamino-carbonylamino, hydroxyC 1-6 alkylamino-carbonylamino, cyano-C 1-6  alkylamino-carbonylamino, C 2-12  dialkylamino-carbonylamino, C 2-12  dialkylamino-C 1-6 alkyl-carbonylamino, C 2-6  di(haloalkyl)amino-carbonylamino, C 2-6  alkenylamino-carbonyl-amino, C 2-6  alkynylamino-carbonylamino, C 1-6  alkoxy-amino-carbonylamino, C 1-6  alkyl-sulfonylamino, C 1-6 alkenyloxy-amino-carbonylamino, C 1-6 alkyl-thiocarbonylamino, C 3-6  cyclo-alkyl-carbonylamino, C 3-6  halocycloalkyl-carbonylamino, C 4-12  cycloalkylalkyl-carbonylamino, C 3-6  cycloalkyl-thiocarbonylamino, C 4-12  cycloalkylalkyl-thiocarbonylamino, C 1-6 haloalkyl-thiocarbonylamino, C 1-6 alkylamino-thiocarbonylamino, C 3-6  cycloalkylamino-carbonylamino, C 3-6  halocycloalkylamino-carbonylamino, C 4-12  cycloalkylalkylamino-carbonylamino, C 3-6  cyclo-alkylamino-thiocarbonylamino, C 4-12  cycloalkylalkylaminothiocarbonylamino, C 1-6  haloalkylamino-thiocarbonylamino, C 2-12  dialkylamino-thiocarbonylamino, C 3-6 cycloalkyloxy-carbonylamino, C 4-12  cycloalkylalkyloxy-carbonylamino, C 1-6  haloalkoxy-carbonylamino, C 1-6  alkylsulfonylamino, C 1-6  haloalkylsulfonylamino, C 1-6  alkylsulfonylamino, phenylsulfonylamino, phenyl-C 1-6  alkylamino, 2-pyridyl-C 1-6  alkylamino, 3-pyridyl-C 1-6  alkylamino, 4-pyridyl-C 1-6  alkylamino, phenyl-carbonyl-amino, halo-phenyl-carbonylamino, azetidine-1-yl-carbonylamino, pyrrolidine-1-yl-carbonylamino, N-methyl-pyrrolidine-2-yl-carbonylamino, furan-2-yl-carbonylamino, trifluoromethylphenyl-carbonylamino, phenylamino-carbonylamino, halophenylamino-carbonylamino, trifluoromethylphenylamino-carbonylamino, 2-pyridyl-carbonylamino, 3-pyridyl-carbonylamino, 4-pyridyl-carbonylamino, phenyl-thiocarbonylamino, 2-pyridyl-thiocarbonylamino, 3-pyridyl-thiocarbonylamino, 4-pyridyl-thiocarbonylamino, phenyl-C 1-6  alkyl-carbonylamino, 2-pyridyl-C 1-6 alkyl-carbonylamino, 3-pyridyl-C 1-6 alkylcarbonyl, 4-pyridyl-C 1-6  alkylcarbony, phenyl-C 1-6  alkyl-thiocarbonyl, 2-pyridyl-C 1-6  alkyl-thiocarbonyl, 3-pyridyl-C 1-6 alkyl-thiocarbonylamino, 4-pyridyl-C 1-6  alkyl-thiocarbonylamino, phenyl-oxy-carbonylamino, 2-pyridyloxy-carbonylamino, 3-pyridyloxy-carbonylamino, 4-pyridyloxy-carbonylamino, phenyl-C 1-6 alkyloxy-carbonylamino, 2-pyridyl-C 1-6 alkyloxy-carbonylamino, 3-pyridyl-C 1-6  alkyloxy-carbonylamino, 4-pyridyl-C 1-6  alkyloxy-carbonylamino, phenyl-amino-carbonylamino, 2-pyridyl-amino-carbonylamino, 3-pyridyl-amino-carbonylamino, 4-pyridyl-amino-carbonylamino, phenyl-amino-thiocarbonyl-amino, 2-pyridylamino-thiocarbonylamino, 3-pyridylamino-thiocarbonylamino, 4-pyridylamino-thiocarbonylamino, phenyl-C 1-6  alkylamino-carbonylamino, 2-pyridyl-C 1-6  alkylamino-carbonyl-amino, 3-pyridyl-C 1-6  alkylamino-carbonylamino, 4-pyridyl-C 1-6  alkylamino-carbonylamino, phenyl-C 1-6  alkylamino-thiocarbonylamino, 2-pyridyl-C 1-6 alkylamino-thiocarbonylamino, 3-pyridyl-C 1-6  alkylamino-thiocarbonylamino or 4-pyridyl-C 1-6  alkylamino-thiocarbonylamino, 1,2,3-triazole-4-trimethylsilyl-1-yl, 1,2,3-triazole-1-yl, succinimide-1-yl, —N 3 , phthalimide-2-yl, C 1-6  alkylcarbonyloxy, more preferably represents amino, hydroxy, carbonylamino, C 1-6  alkyl-sulfonylamino, C 1-6  alkylamino-carbonylamino, C 1-6  alkyl-thiocarbonylamino, C 1-6  alkyl-carbonyl-amino, C 1-6  alkylcarbonyl-C 1-6  alkyl-carbonylamino, alkylsulfenyl-C 1-6  alkyl-carbonylamino, C 1-6  alkylsulfenyl-C 1-6 alkyl-carbonylamino, C 1-6  alkylsulfinyl-C 1-6  alkyl-carbonylamino, C 1-6  alkyl-sulfonyl-C 1-6 alkyl-carbonylamino, C 1-6  haloalkyl-carbonylamino, cyano-C 1-6  alkyl-carbonylamino, C 1-6  alkenyl-carbonylamino, C 1-6  alkynyl-carbonylamino, C 1-6  alkoxy-carbonylamino, C 1-6 haloalkoxy-carbonylamino, cyano-C 1-6 alkoxy-carbonylamino, C 1-6  alkoxy C 1-6  alkylamino-carbonylamino, C 1-6  alkoxy-C 1-6  alkoxy-carbonylamino, amino-carbonylamino, C 1-6  alkylamino-carbonylamino, C 1-6 haloalkylamino-carbonylamino, hydroxy-C 1-6 -alkylamino-carbonylamino, cyano-C 1-6  alkylamino-carbonylamino, C 2-12  dialkylamino-carbonylamino, C 2-12  dialkylamino-C 1-6  alkyl-carbonylamino, C 2-6  alkynylamino-carbonylamino, C 1-6  alkoxy-amino-carbonylamino, C 1-6  alkenyloxy-amino-carbonylamino, C 3-6  cycloalkyl-carbonylamino, C 3-6  halocycloalkyl-carbonylamino, C 4-12  cycloalkylalkyl-carbonylamino, C 1-6  alkylamino-thiocarbonylamino, C 3-6  cycloalkylamino-carbonylamino, C 3-6  halocycloalkylamino-carbonylamino, C 4-12  cycloalkyl-alkylamino-carbonylamino, C 1-6 haloalkylsulfonylamino, phenyl-carbonylamino, halo-phenyl-carbonylamino, azetidine-1-yl-carbonylamino, pyrrolidine-1-yl-carbonylamino, N-methyl-pyrrolidine-2-yl-carbonylamino, furan-2-yl-carbonylamino, tirfluoromethylphenyl-carbonylamino, phenylamino-carbonylamino, halophenylamino-carbonylamino, trifluoromethylphenylamino-carbonylamino, 1,2,3-triazole-4-trimethylsilyl-1-yl, 1,2,3-triazole-1-yl, succinimide-1-yl, —N 3 , phthalimide-2-yl, C 1-6  alkylcarbonyloxy, most preferably represents C 1-6  haloalkyl-carbonylamino, C 1-6  alkylamino-carbonylamino, C 1-6  haloalkylamino-carbonylamino, C 1-6  alkylamino-carbonyl-amino and C 1-6 haloalkylamino-carbonylamino. 
     Embodiment G: Compounds having the structure (I-g-1) or (I-g-2), wherein the chemical groups A, R 1 , Q, X, Y, m, n, and W′ are as defined herein and wherein W″ is selected among hydrogen, halogen, hydroxy, thiol, cyano, C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  alkylsulfenyl, C 1-6  alkyl-sulfinyl, C 1-6 alkylsulfonyl 
     
       
         
         
             
             
         
       
     
     Embodiment G1: Compounds as defined in embodiment G, wherein the group Q is selected among Q-1, Q-2, Q-42 to Q-54 and X is independently selected among hydrogen, halogen, amino, C 1-6  alkylamino, C 2-12  dialkylamino, nitro, C 1-6 alkoxy, and C 1-6 haloalkyl. 
     Embodiment G2: Compounds as defined in embodiment G or G1, wherein A represents oxygen or CH 2 , R 1  represents CF 3 , and Y is H. 
     In these embodiments, W′ preferably represents hydrogen, C 1-6  alkyl, C 1-6  alkylcarbonyl, C 1-6 haloalkylcarbonyl, C 1-6 alkenylcarbonyl, C 1-6 haloalkenylcarbonyl, C 1-6  alkynylcarbonyl, C 1-6 haloalkynylcarbonyl, C 1-6 alkoxycarbonyl, aminocarbonyl, C 1-6  alkylaminocarbonyl, C 1-6 haloalkylaminocarbonyl, C 1-6  hydroxyalkylaminocarbonyl, C 2-12  dialkylamino-carbonyl, C 2-6  di(haloalkyl)aminocarbonyl, C 2-6 alkenylaminocarbonyl, C 2-6  alkynylaminocarbonyl, C 1-6  alkyl-thiocarbonyl, C 3-6  cycloalkylcarbonyl, C 4-12  cycloalkylalkyl-carbonyl, C 3-6  cycloalkyl-thiocarbonyl, C 4-12  cycloalkylalkyl-thiocarbonyl, C 1-6 haloalkyl-thiocarbonyl, C 1-6  alkylamino-thiocarbonyl, C 2-6 cycloalkylamino-carbonyl, C 4-12  cycloalkylalkylamino-carbonyl, C 3-6  cycloalkylamino-thiocarbonyl, C 4-12  cycloalkylalkylaminothiocarbonyl, C 1-6 haloalkylamino-thiocarbonyl, C 2-12  dialkylamino-thiocarbonyl, C 2-6 cycloalkyloxy-carbonyl, C 4-12 cycloalkylalkyloxy-carbonyl, C 1-6 haloalkoxy-carbonyl, C 1-6  alkylsulfonyl, C 1-6 haloalkylsulfonyl, phenylsulfonyl, phenyl-C 1-6  alkyl, 2-pyridyl-C 1-6  alkyl, 3-pyridyl-C 1-6 alkyl, 4-pyridyl-C 1-6  alkyl, phenylcarbonyl, 2-pyridylcarbonyl, 3-pyridylcarbonyl, 4-pyridylcarbonyl, phenyl-thiocarbonyl, 2-pyridyl-thiocarbonyl, 3-pyridyl-thiocarbonyl, 4-pyridyl-thiocarbonyl, phenyl-C 1-6  alkylcarbonyl, 2-pyridyl-C 1-6 alkylcarbonyl, 3-pyridyl-C 1-6 alkylcarbonyl, 4-pyridyl-C 1-6  alkylcarbony, phenyl-C 1-6 alkyl-thiocarbonyl, 2-pyridyl-C 1-6 alkyl-thiocarbonyl, 3-pyridyl-C 1-6 alkyl-thiocarbonyl, 4-pyridyl-C 1-6 alkyl-thiocarbonyl, phenyl-oxycarbonyl, 2-pyridyloxycarbonyl, 3-pyridyl-oxycarbonyl, 4-pyridyloxycarbonyl, phenyl-C 1-6  alkyloxy-carbonyl, 2-pyridyl-C 1-6 alkyloxy-carbonyl, 3-pyridyl-C 1-6 alkyloxy-carbonyl, 4-pyridyl-C 1-6  alkyloxy-carbonyl, phenyl-aminocarbonyl, 2-pyridyl-amino-carbonyl, 3-pyridyl-aminocarbonyl, 4-pyridyl-aminocarbonyl, phenyl-amino-thiocarbonyl, 2-pyridylamino-thiocarbonyl, 3-pyridylamino-thiocarbonyl, 4-pyridylamino-thiocarbonyl, phenyl-C 1-6  alkylamino-carbonyl, 2-pyridyl-C 1-6  alkylamino-carbonyl, 3-pyridyl-C 1-6 alkylamino-carbonyl, 4-pyridyl-C 1-6  alkylamino-carbonyl, phenyl-C 1-6 alkylamino-thiocarbonyl, 2-pyridyl-C 1-6  alkyl-amino-thiocarbonyl, 3-pyridyl-C 1-6  alkylamino-thiocarbonyl or 4-pyridyl-C 1-6 alkylamino-thiocarbonyl, more preferably represents hydrogen, C 1-6  alkyl, C 1-6 alkylcarbonyl, C 1-6  alkylamino-carbonyl, C 1-6  haloalkylaminocarbonyl, C 2-6  alkenylaminocarbonyl, C 2-6  alkynylaminocarbonyl, C 3-6  cycloalkylamino-carbonyl, C 4-12  cycloalkylalkylamino-carbonyl. 
     Embodiment H: Compounds having the following structure (I-h-1) or (I-h-2), wherein the chemical groups A, R 1 , Q, X, Y, m, n, W′ and U are as defined herein, and wherein W″ is selected among hydrogen, halogen, hydroxy, thiol, cyano, C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  alkyl-sulfenyl, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl. 
     
       
         
         
             
             
         
       
     
     Embodiment H1: Compounds as defined in embodiment H, wherein the group Q is selected among Q-1, Q-2, Q-42 to Q-54 and X is independently selected among hydrogen, halogen, amino, C 1-6  alkylamino, C 2-12  dialkylamino, nitro, C 1-6  alkoxy, and C 1-6  haloalkyl. 
     Embodiment H2: Compounds as defined in embodiment H or H1, wherein A represents oxygen or CH 2 , R 1  represents CF 3 , and Y is H and/or U stands for O, C 1-6  alkyl-N, pyridin-2-yl-C 1-6  alkyl-N or H—N. 
     Embodiment I: Compounds having the structure (I-i-1) or (I-i-2) wherein the chemical groups A, R 1 , Q, X, Y, m, n, W′ and U are as defined herein, and wherein W″ is selected among hydrogen, halogen, hydroxy, thiol, cyano, C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  alkylsulfenyl, C 1-6 alkyl-sulfinyl, C 1-6 alkylsulfonyl. 
     
       
         
         
             
             
         
       
     
     Embodiment I1: Compounds as defined in embodiment I, wherein the group Q is selected among Q-1, Q-2, Q-42 to Q-54 and X is independently selected among hydrogen, halogen, amino, C 1-6  alkylamino, C 2-12  dialkylamino, nitro, C 1-6  alkoxy, and C 1-6  haloalkyl. 
     Embodiment I2: Compounds as defined in embodiment I or I1, wherein A represents oxygen or CH 2 , R 1  represents CF 3 , and Y is H and/or U stands for O or C 1-6  alkyl-carbonyl-N. 
     In these embodiments, W′ preferably represents hydrogen; formyl; C 1-6  alkyl, C 2-12  (total carbon number) alkoxyalkyl, C 2-12  (total carbon number) haloalkoxyalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-8  cycloalkyl, C 4-12  (total carbon number) alkylcycloalkyl, C 4-12  (total carbon number) cycloalkylalkyl, phenyl, halophenyl, pyrimidin-2-yl, C 1-6  haloalkyl, C 1-6  alkylimino, C 1-6  haloalkylimino, C 1-6  alkyl-carbonyl, C 1-6  alkenyl-carbonyl, C 1-6  alkynyl-carbonyl, C 1-6  haloalkyl-carbonyl, C 1-6  alkoxy-carbonyl, C 1-6  haloalkoxy-carbonyl, aminocarbonyl, C 1-6  alkylamino-carbonyl, C 1-6  haloalkylamino-carbonyl, C 1-6  hydroxyalkylamino-carbonyl, C 2-12  (total carbon number) dialkyl-amino-carbonyl, C 2-6  (total carbon number) di(haloalkyl)aminocarbonyl, C 2-6  alkenylamino-carbonyl, C 2-6  alkynylamino-carbonyl, C 3-6  cycloalkyl-carbonyl, C 4-12  (total carbon number) cyclo-alkylalkyl-carbonyl, C 3-6  cycloalkylamino-carbonyl, C 4-12  (total carbon number) cycloalkylalkyl-amino-carbonyl, C 3-6 cycloalkyloxy-carbonyl, C 4-12  (total carbon number) cycloalkylalkyl-oxy-carbonyl, C 1-6  haloalkoxy-carbonyl, phenyl-C 1-6  alkyl, halophenyl-C 1-6  alkyl, 2-pyridyl-C 1-6  alkyl, 3-pyridyl-C 1-6  alkyl, 4-pyridyl-C 1-6  alkyl, phenylcarbonyl, 2-pyridylcarbonyl, 3-pyridyl-carbonyl, 4-pyridylcarbonyl, phenyl-C 1-6 alkylcarbonyl, 2-pyridyl-C 1-6  alkylcarbonyl, 3-pyridyl-C 1-6  alkylcarbonyl, 4-pyridyl-C 1-6 alkylcarbony, phenyloxy-carbonyl, 2-pyridyloxy-carbonyl, 3-pyridyloxy-carbonyl, 4-pyridyloxy-carbonyl, phenyl-C 1-6  alkyloxy-carbonyl, 2-pyridyl-C 1-6  alkyl-oxy-carbonyl, 3-pyridyl-C 1-6 alkyloxy-carbonyl, 4-pyridyl-C 1-6 alkyloxy-carbonyl, phenyl-amino-carbonyl, 2-pyridyl-aminocarbonyl, 3-pyridyl-aminocarbonyl, 4-pyridyl-aminocarbonyl, phenyl-C 1-6 alkylamino-carbonyl, 2-pyridyl-C 1-6  alkylamino-carbonyl, 3-pyridyl-C 1-6 alkylamino-carbonyl or 4-pyridyl-C 1-6 alkylamino-carbonyl, more preferably represents hydrogen, C 1-6  alkyl, C 2-12  (total carbon number) alkoxyalkyl, C 2-6  alkenyl, C 3-8  cycloalkyl, phenyl, halophenyl, pyrimidin-2-yl, C 1-6 haloalkyl, C 1-6  alkyl-carbonyl, phenyl-C 1-6  alkyl, halophenyl-C 1-6  alkyl, 2-pyridyl-C 1-6 alkyl. 
     These embodiments do not include compounds nos. 1-50, 1-52, and 1-52 as defined herein. 
     Embodiment J: Compounds having the structure (I-j-1), wherein the chemical groups A, R 1 , Q, X, Y, m, n, W′ and U are as defined herein, and wherein W″ is selected among hydrogen, halogen, hydroxy, thiol, cyano, C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  alkylsulfenyl, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl. 
     
       
         
         
             
             
         
       
     
     Embodiment J1: Compounds as defined in embodiment J, wherein the group Q is selected among Q-1, Q-2, Q-42 to Q-54 and X is independently selected among hydrogen, halogen, amino, C 1-6  alkylamino, C 2-12  dialkylamino, nitro, C 1-6  alkoxy, and C 1-6  haloalkyl. 
     Embodiment J2: Compounds as defined in embodiment J or J1, wherein A represents oxygen or CH 2 , R 1  represents CF 3 , and Y is H. 
     In these embodiments, W′ preferably represents hydrogen; formyl; C 1-6  alkyl, C 2-12  (total carbon number) alkoxyalkyl, C 2-12  (total carbon number) haloalkoxyalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-8  cycloalkyl, C 4-12  (total carbon number) alkylcycloalkyl, C 4-12  (total carbon number) cycloalkylalkyl, C 1-6 haloalkyl, C 1-6 alkylimino, C 1-6 haloalkylimino, C 1-6  alkyl-carbonyl, C 1-6  alkenyl-carbonyl, C 1-6  alkynyl-carbonyl, C 1-6  haloalkyl-carbonyl, C 1-6  alkoxy-carbonyl, C 1-6  haloalkoxy-carbonyl, aminocarbonyl, C 1-6  alkylamino-carbonyl, C 1-6 haloalkylamino-carbonyl, C 1-6 hydroxyalkylamino-carbonyl, C 2-12  (total carbon number) dialkylamino-carbonyl, C 2-6  (total carbon number) di(haloalkyl)aminocarbonyl, C 2-6  alkenylamino-carbonyl, C 2-6  alkynylamino-carbonyl, C 3-6  cyclo-alkyl-carbonyl, C 4-12  (total carbon number) cycloalkylalkyl-carbonyl, C 3-6  cycloalkylamino-carbonyl, C 4-12  (total carbon number) cycloalkylalkylamino-carbonyl, C 3-6  cycloalkyloxy-carbonyl, C 4-12  (total carbon number) cycloalkylalkyloxy-carbonyl, C 1-6  haloalkoxy-carbonyl, phenyl-C 1-6 alkyl, 2-pyridyl-C 1-6  alkyl, 3-pyridyl-C 1-6  alkyl, 4-pyridyl-C 1-6 alkyl, phenylcarbonyl, 2-pyridylcarbonyl, 3-pyridylcarbonyl, 4-pyridylcarbonyl, phenyl-C 1-6  alkylcarbonyl, 2-pyridyl-C 1-6  alkylcarbonyl, 3-pyridyl-C 1-6 alkylcarbonyl, 4-pyridyl-C 1-6 alkylcarbony, phenyloxy-carbonyl, 2-pyridyloxy-carbonyl, 3-pyridyloxy-carbonyl, 4-pyridyloxy-carbonyl, phenyl-C 1-6  alkyl-oxy-carbonyl, 2-pyridyl-C 1-6 alkyloxy-carbonyl, 3-pyridyl-C 1-6 alkyloxy-carbonyl, 4-pyridyl-C 1-6  alkyloxy-carbonyl, phenyl-aminocarbonyl, 2-pyridyl-aminocarbonyl, 3-pyridyl-amino-carbonyl, 4-pyridyl-aminocarbonyl, phenyl-C 1-6  alkylamino-carbonyl, 2-pyridyl-C 1-6 alkylamino-carbonyl, 3-pyridyl-C 1-6  alkylamino-carbonyl or 4-pyridyl-C 1-6 alkylamino-carbonyl, more preferably represents hydrogen; C 1-6  alkyl-carbonyl, phenyl-C 1-6  alkyl, or 2-pyridyl-C 1-6  alkyl. 
     Embodiment K: Compounds having the structure (I-k-1), wherein the chemical groups A, R 1 , Q, X, Y, m, n, W′ and U are as defined herein, and wherein W″ is selected among hydrogen, halogen, hydroxy, thiol, cyano, C 1-6  alkyl, C 1-6 haloalkyl, C 1-6  alkoxy, C 1-6  alkylsulfenyl, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl. 
     
       
         
         
             
             
         
       
     
     Embodiment K1: Compounds as defined in embodiment K, wherein the group Q is selected among Q-1, Q-2, Q-42 to Q-54 and X is independently selected among hydrogen, halogen, amino, C 1-6  alkylamino, C 2-12  dialkylamino, nitro, C 1-6  alkoxy, and C 1-6 haloalkyl. 
     Embodiment K2: Compounds as defined in embodiment K or K1, wherein A represents oxygen or CH 2 , R 1  represents CF 3 , and Y is H and/or U stands for O, hydroxy-N, C 1-6  alkoxy-N, C 1-6  haloalkoxy-N, C 1-6  alkylamino-N, C 2-12  di(alkyl)amino-N, 2-pyridyl-C 1-6  alkoxy-N, C 1-6  alkyl-carbonylamino-N, or C 1-6 haloalkylamino-N. 
     Embodiment L: Compounds having the structure (I-1-1), wherein the chemical groups A, R 1 , Q, X, Y, m, n, W′ and U are as defined herein, and wherein W″ is selected among hydrogen, halogen, hydroxy, thiol, cyano, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 alkylsulfenyl, C 1-6  alkylsulfinyl, C 1-6 alkylsulfonyl. 
     
       
         
         
             
             
         
       
     
     Embodiment L1: Compounds as defined in embodiment L, wherein the group Q is selected among Q-1, Q-2, Q-42 to Q-54 and X is independently selected among hydrogen, halogen, amino, C 1-6  alkylamino, C 2-12  dialkylamino, nitro, C 1-6 alkoxy, and C 1-6 haloalkyl. 
     Embodiment L2: Compounds as defined in embodiment L or L1, wherein A represents oxygen or CH 2 , R 1  represents CF 3 , Y is H and/or U stands for O. 
     In these embodiments, W′ preferably represents hydrogen; formyl; C 1-6  alkyl, C 2-12  (total carbon number) alkoxyalkyl, C 2-12  (total carbon number) haloalkoxyalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-8  cycloalkyl, C 4-12  (total carbon number) alkylcycloalkyl, C 4-12  (total carbon number) cycloalkylalkyl, C 1-6 haloalkyl, C 1-6  alkylimino, C 1-6 haloalkylimino, C 1-6  alkenyl-carbonyl, C 1-6  alkynyl-carbonyl, C 1-6 haloalkyl-carbonyl, C 1-6  alkoxy-carbonyl, C 1-6  haloalkoxy-carbonyl, aminocarbonyl, C 1-6  alkyl-amino-carbonyl, C 1-6  haloalkylamino-carbonyl, C 1-6  hydroxyalkylamino-carbonyl, C 2-12  (total carbon number) dialkylamino-carbonyl, C 2-6  (total carbon number) di(haloalkyl)aminocarbonyl, C 2-6  alkenylamino-carbonyl, C 2-6  alkynylamino-carbonyl, C 3-6  cycloalkyl-carbonyl, C 4-12  (total carbon number) cycloalkylalkyl-carbonyl, C 3-6  cycloalkylamino-carbonyl, C 4-12  (total carbon number) cycloalkylalkylamino-carbonyl, C 3-6  cycloalkyloxy-carbonyl, C 4-12  (total carbon number) cycloalkylalkyloxy-carbonyl, C 1-6 haloalkoxy-carbonyl, phenyl-C 1-6  alkyl, 2-pyridyl-C 1-6  alkyl, 3-pyridyl-C 1-6  alkyl, 4-pyridyl-C 1-6  alkyl, phenylcarbonyl, 2-pyridylcarbonyl, 3-pyridylcarbonyl, 4-pyridylcarbonyl, phenyl-C 1-6 alkylcarbonyl, 2-pyridyl-C 1-6 alkylcarbonyl, 3-pyridyl-C 1-6  alkyl-carbonyl, 4-pyridyl-C 1-6 alkylcarbony, phenyloxy-carbonyl, 2-pyridyloxy-carbonyl, 3-pyridyloxy-carbonyl, 4-pyridyloxy-carbonyl, phenyl-C 1-6 alkyloxy-carbonyl, 2-pyridyl-C 1-6  alkyl-oxy-carbonyl, 3-pyridyl-C 1-6  alkyloxy-carbonyl, 4-pyridyl-C 1-6 alkyloxy-carbonyl, phenyl-amino-carbonyl, 2-pyridyl-aminocarbonyl, 3-pyridyl-aminocarbonyl, 4-pyridyl-aminocarbonyl, phenyl-C 1-6  alkylamino-carbonyl, 2-pyridyl-C 1-6 alkylamino-carbonyl, 3-pyridyl-C 1-6 alkylamino-carbonyl or 4-pyridyl-C 1-6 alkylamino-carbonyl, more preferably represents hydrogen or C 1-6 alkyl 
     Embodiment M: Compounds having the following structure (I-m-1), wherein the chemical groups A, R 1 , Q, X, Y, m, n, W and U are as defined herein, and wherein W″ is selected among hydrogen, halogen, hydroxy, thiol, cyano, C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  alkylsulfenyl, C 1-6 alkyl-sulfinyl, C 1-6  alkylsulfonyl. 
     
       
         
         
             
             
         
       
     
     Embodiment M1: Compounds as defined in embodiment M, wherein the group Q is selected among Q-1, Q-2, Q-42 to Q-54 and X is independently selected among hydrogen, halogen, amino, C 1-6  alkylamino, C 2-12  dialkylamino, nitro, C 1-6  alkoxy, and C 1-6  haloalkyl. 
     Embodiment M2: Compounds as defined in embodiment M or M1, wherein A represents oxygen or CH 2 , R 1  represents CF 3 , Y is H and/or U stands for O. 
     In these embodiments, W′ preferably represents hydrogen; formyl; C 1-6  alkyl, C 2-12  (total carbon number) alkoxyalkyl, C 2-12  (total carbon number) haloalkoxyalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-8  cycloalkyl, C 4-12  (total carbon number) alkylcycloalkyl, C 4-12  (total carbon number) cycloalkylalkyl, C 1-6  haloalkyl, C 1-6  alkylimino, C 1-6 haloalkylimino, C 1-6  alkenyl-carbonyl, C 1-6  alkynyl-carbonyl, C 1-6  haloalkyl-carbonyl, C 1-6  alkoxy-carbonyl, C 1-6 haloalkoxy-carbonyl, aminocarbonyl, C 1-6  alkyl-amino-carbonyl, C 1-6  haloalkylamino-carbonyl, C 1-6  hydroxyalkylamino-carbonyl, C 2-12  (total carbon number) dialkylamino-carbonyl, C 2-6  (total carbon number) di(haloalkyl)aminocarbonyl, C 2-6 alkenylamino-carbonyl, C 2-6  alkynylamino-carbonyl, C 3-6  cycloalkyl-carbonyl, C 4-12  (total carbon number) cycloalkylalkyl-carbonyl, C 3-6  cycloalkylamino-carbonyl, C 4-12  (total carbon number) cycloalkylalkylamino-carbonyl, C 3-6  cycloalkyloxy-carbonyl, C 4-12  (total carbon number) cycloalkylalkyloxy-carbonyl, C 1-6  haloalkoxy-carbonyl, phenyl-C 1-6  alkyl, 2-pyridyl-C 1-6  alkyl, 3-pyridyl-C 1-6 alkyl, 4-pyridyl-C 1-6 alkyl, phenylcarbonyl, 2-pyridylcarbonyl, 3-pyridylcarbonyl, 4-pyridylcarbonyl, phenyl-C 1-6 alkylcarbonyl, 2-pyridyl-C 1-6 alkylcarbonyl, 3-pyridyl-C 1-6  alkyl-carbonyl, 4-pyridyl-C 1-6  alkylcarbony, phenyloxy-carbonyl, 2-pyridyloxy-carbonyl, 3-pyridyloxy-carbonyl, 4-pyridyloxy-carbonyl, phenyl-C 1-6  alkyloxy-carbonyl, 2-pyridyl-C 1-6 alkyl-oxy-carbonyl, 3-pyridyl-C 1-6  alkyloxy-carbonyl, 4-pyridyl-C 1-6  alkyloxy-carbonyl, phenyl-amino-carbonyl, 2-pyridyl-aminocarbonyl, 3-pyridyl-aminocarbonyl, 4-pyridyl-aminocarbonyl, phenyl-C 1-6 alkylamino-carbonyl, 2-pyridyl-C 1-6 alkylamino-carbonyl, 3-pyridyl-C 1-6 alkylamino-carbonyl or 4-pyridyl-C 1-6 alkylamino-carbonyl. 
     Embodiment N: Compounds having the structure (I-n-1), wherein the chemical groups A, R 1 , Q, X, Y, m, n and W′ are as defined herein. 
     
       
         
         
             
             
         
       
     
     Embodiment N1: Compounds as defined in embodiment N, wherein the group Q is selected among Q-1, Q-2, Q-42 to Q-54 and X is independently selected among hydrogen, halogen, amino, C 1-6  alkylamino, C 2-12  dialkylamino, nitro, C 1-6 alkoxy, and C 1-6 haloalkyl. 
     Embodiment N2: Compounds as defined in embodiment N or N1, wherein A represents oxygen or CH 2 , R 1  represents CF 3 , and Y is H. 
     In these embodiments, W′ preferably represents amino, hydroxy, C 1-6  alkyl-carbonylamino, C 1-6 haloalkyl-carbonylamino, C 1-6 alkenyl-carbonylamino, C 1-6 haloalkenyl-carbonylamino, C 1-6  alkynyl-carbonylamino, C 1-6  haloalkynyl-carbonylamino, C 1-6  alkoxy-carbonylamino, amino-carbonylamino, C 1-6  alkylamino-carbonylamino, C 1-6  haloalkylamino-carbonylamino, C 1-6  hydroxyalkylamino-carbonylamino, C 2-12  dialkylamino-carbonylamino, C 2-6  di(haloalkyl)-amino-carbonylamino, C 2-6  alkenylamino-carbonylamino, C 2-6 alkynylamino-carbonylamino, C 1-6 alkyl-thiocarbonylamino, C 3-6  cycloalkyl-carbonylamino, C 4-12  cycloalkylalkyl-carbonylamino, C 3-6  cycloalkyl-thiocarbonylamino, C 4-12  cycloalkylalkyl-thiocarbonylamino, C 1-6  haloalkyl-thiocarbonylamino, C 1-6 alkylamino-thiocarbonylamino, C 3-6  cycloalkylamino-carbonylamino, C 4-12  cycloalkylalkylamino-carbonylamino, C 3-6  cycloalkylamino-thiocarbonylamino, C 4-12  cyclo-alkylalkylaminothiocarbonylamino, C 1-6 haloalkylamino-thiocarbonylamino, C 2-12  dialkylamino-thiocarbonylamino, C 3-6  cycloalkyloxy-carbonylamino, C 4-12  cycloalkylalkyloxy-carbonylamino, C 1-6 haloalkoxy-carbonylamino, C 1-6 alkylsulfonylamino, C 1-6 haloalkylsulfonylamino, phenyl-sulfonylamino, phenyl-C 1-6  alkylamino, 2-pyridyl-C 1-6 alkylamino, 3-pyridyl-C 1-6  allylamino, 4-pyridyl-C 1-6 alkylamino, phenyl-carbonylamino, 2-pyridyl-carbonylamino, 3-pyridyl-carbonyl-amino, 4-pyridyl-carbonylamino, phenyl-thiocarbonylamino, 2-pyridyl-thiocarbonylamino, 3-pyridyl-thiocarbonylamino, 4-pyridyl-thiocarbonylamino, phenyl-C 1-6 alkyl-carbonylamino, 2-pyridyl-C 1-6 alkyl-carbonylamino, 3-pyridyl-C 1-6 alkylcarbonyl, 4-pyridyl-C 1-6  alkylcarbony, phenyl-C 1-6 alkyl-thiocarbonyl, 2-pyridyl-C 1-6 alkyl-thiocarbonyl, 3-pyridyl-C 1-6 alkyl-thiocarbonyl-amino, 4-pyridyl-C 1-6 alkyl-thiocarbonylamino, phenyl-oxy-carbonylamino, 2-pyridyloxy-carbonyl-amino, 3-pyridyloxy-carbonylamino, 4-pyridyloxy-carbonylamino, phenyl-C 1-6  alkyloxy-carbonyl-amino, 2-pyridyl-C 1-6 alkyloxy-carbonylamino, 3-pyridyl-C 1-6  alkyloxy-carbonylamino, 4-pyridyl-C 1-6  alkyloxy-carbonylamino, phenyl-amino-carbonylamino, 2-pyridyl-amino-carbonylamino, 3-pyridyl-amino-carbonylamino, 4-pyridyl-amino-carbonylamino, phenyl-amino-thiocarbonyl-amino, 2-pyridylamino-thiocarbonylamino, 3-pyridylamino-thiocarbonylamino, 4-pyridylamino-thiocarbonylamino, phenyl-C 1-6  alkylamino-carbonylamino, 2-pyridyl-C 1-6 alkylamino-carbonyl-amino, 3-pydidyl-C 1-6 alkylamino-carbonylamino, 4-pyridyl-C 1-6  alkylamino-carbonylamino, phenyl-C 1-6 alkyl amino-thiocarbonylamino, 2-pyridyl-C 1-6 alkylamino-thiocarbonylamino, 3-pydidyl-C 1-6 alkylamino-thiocarbonylamino or 4-pyridyl-C 1-6 alkylamino-thiocarbonylamino, more preferably represents amino, C 1-6 alkyl-carbonylamino, C 1-6  alkoxy-carbonylaminoC 3-6 cyclo-alkyl-carbonylamino. 
     Embodiment O: Compounds having the structure (I-o-1), wherein the chemical groups A, R 1 , Q, X, Y, m, W′ and n are as defined herein, and wherein W″ is selected among hydrogen, halogen, hydroxy, thiol, cyano, C 1-6  alkyl, C 1-6  haloalkyl, C 1-6  alkoxy, C 1-6  alkylsulfenyl, C 1-6 alkylsulfinyl, C 1-6 alkylsulfonyl. 
     
       
         
         
             
             
         
       
     
     Embodiment O1: Compounds as defined in embodiment 0, wherein the group Q is selected among Q-1, Q-2, Q-42 to Q-54 and X is independently selected among hydrogen, halogen, amino, C 1-6  alkylamino, C 2-12  dialkylamino, nitro, C 1-6  alkoxy, and C 1-6  haloalkyl. 
     Embodiment O2: Compounds as defined in embodiment O or O1, wherein A represents oxygen or CH 2 , R 1  represents CF 3 , and Y is H. 
     In these embodiments, W′ preferably represents hydrogen; cyano, halogen. formyl; C 1-6  alkyl, C 2-12  (total carbon number) alkoxyalkyl, C 2-12  (total carbon number) haloalkoxyalkyl, C 2-6  alkenyl, C 2-6  alkynyl, C 3-8  cycloalkyl, C 4-12  (total carbon number) alkylcycloalkyl, C 4-12  (total carbon number) cycloalkylalkyl, C 1-6  haloalkyl, C 1-6  alkylimino, C 1-6 haloalkylimino, C 1-6  alkenyl-carbonyl, C 1-6  alkynyl-carbonyl, C 1-6 haloalkyl-carbonyl, C 1-6  alkoxy-carbonyl, C 1-6 haloalkoxy-carbonyl, aminocarbonyl, C 1-6  alkylamino-carbonyl, C 1-6  haloalkylamino-carbonyl, C 1-6  hydroxyalkylamino-carbonyl, C 2-12  (total carbon number) dialkylamino-carbonyl, C 2-6  (total carbon number) di(haloalkyl)aminocarbonyl, C 2-6  alkenylamino-carbonyl, C 2-6  alkynylamino-carbonyl, C 3-6  cyclo-alkyl-carbonyl, C 4-12  (total carbon number) cycloalkylalkyl-carbonyl, C 3-6  cycloalkylamino-carbonyl, C 4-12  (total carbon number) cycloalkylalkylamino-carbonyl, C 3-6  cycloalkyloxy-carbonyl, C 4-12  (total carbon number) cycloalkylalkyloxy-carbonyl, C 1-6 haloalkoxy-carbonyl, phenyl-C 1-6  alkyl, 2-pyridyl-C 1-6  alkyl, 3-pyridyl-C 1-6  alkyl, 4-pyridyl-C 1-6  alkyl, phenylcarbonyl, 2-pyridylcarbonyl, 3-pyridylcarbonyl, 4-pyridylcarbonyl, phenyl-C 1-6  alkylcarbonyl, 2-pyridyl-C 1-6 alkylcarbonyl, 3-pyridyl-C 1-6  alkylcarbonyl, 4-pyridyl-C 1-6  alkylcarbony, phenyloxy-carbonyl, 2-pyridyloxy-carbonyl, 3-pyridyloxy-carbonyl, 4-pyridyloxy-carbonyl, phenyl-C 1-6  allyl-oxy-carbonyl, 2-pyridyl-C 1-6 alkyloxy-carbonyl, 3-pyridyl-C 1-6 alkyloxy-carbonyl, 4-pyridyl-C 1-6 alkyloxy-carbonyl, phenyl-aminocarbonyl, 2-pyridyl-aminocarbonyl, 3-pyridyl-amino-carbonyl, 4-pyridyl-aminocarbonyl, phenyl-C 1-6  alkylamino-carbonyl, 2-pyridyl-C 1-6 alkylamino-carbonyl, 3-pyridyl-C 1-6  alkylamino-carbonyl or 4-pyridyl-C 1-6  alkylamino-carbonyl. 
     Embodiment V: Compounds having the structure (I-v-1), wherein the chemical groups A, R 1 , Q, X, Y, m, n, W′, and U are as defined herein, and wherein W″ is selected among hydrogen, halogen, hydroxy, thiol, cyano, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 alkylsulfenyl, C 1-6 alkylsulfinyl, C 1-6  alkylsulfonyl. 
     
       
         
         
             
             
         
       
     
     Embodiment V1: Compounds as defined in embodiment V, wherein the group Q is selected among Q-1, Q-2, Q-42 to Q-54 and X is independently selected among hydrogen, halogen, amino, C 1-6  alkylamino, C 2-12  dialkylamino, nitro, C 1-6  alkoxy, and C 1-6 haloalkyl. 
     Embodiment V2: Compounds as defined in embodiment V or V1, wherein A represents oxygen or CH 2 , R 1  represents CF 3 , and Y is H. 
     W′ preferably represents hydrogen. 
     Embodiment Z: Compounds having the structure (I-z-1), wherein the chemical groups A, R 1 , Q, X, Y, m, n, W′, and U are as defined herein, and wherein W″ is selected among hydrogen, halogen, hydroxy, thiol, cyano, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy, C 1-6 alkylsulfenyl, C 1-6 alkylsulfinyl, C 1-6  alkylsulfonyl. 
     
       
         
         
             
             
         
       
     
     Embodiment Z1: Compounds as defined in embodiment Z, wherein the group Q is selected among Q-1, Q-2, Q-42 to Q-54 and X is independently selected among hydrogen, halogen, amino, C 1-6  alkylamino, C 2-12  dialkylamino, nitro, C 1-6 alkoxy, and C 1-6 haloalkyl. 
     Embodiment Z2: Compounds as defined in embodiment Z or Z1, wherein A represents oxygen or CH 2 , R 1  represents CF 3 , and Y is H and/or U stands for O, hydroxy-N, C 1-6  alkoxy-N, C 1-6  haloalkoxy-N. 
     As used herein, the term “alkyl” refers to linear or branched C 1-12  alkyl including, for example, ethyl, methyl, n- or iso-propyl, n-, iso-, sec-, or tert-butyl, n-pentyl, n-hexyl, n-heptyl, n-octyl, n-nonyl, n-decyl, n-undecyl and n-dodecyl, and preferably refers to C 1-6  alkyl. The alkyl moiety in a group having alkyl as a part of its formula may have the same meaning as described for the aforementioned “alkyl”. The alkyl group can be unsubstituted or substituted with at least one suitable substituent. 
     The term “halogen” and a halogen moiety in a group substituted with halogen represents fluorine, chlorine, bromine and iodine. Preferred halogens are fluorine, chlorine and bromine. 
     The term “haloalkyl” used alone or combined with other terms refers to alkyl groups which are partially or fully substituted with halogen atoms which may be the same or different. Examples of “haloalkyl” includes for example CF 3 , CH 2 F, CHF 2 , CCl 3 , CH 2 Cl, CHCl 2 , CF 2 CF 3 , CHFCF 3 , The haloalkyl group can additionally be unsubstituted or substituted with at least one suitable substituent. 
     The term “cycloalkyl” refers to C 3-8  cycloalkyl including, for example, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl and cyclooctyl, and preferably refers to C 3-7  cycloalkyl. The cycloalkyl group can be unsubstituted or substituted with at least one suitable substituent. 
     The term “alkenyl” refers to C 2-5  alkenyl including, for example, vinyl, allyl, 1-propenyl, 1-(or 2- or 3-) butenyl and 1-pentenyl, and preferably refers to C 2-4  alkenyl. The alkenyl group can be unsubstituted or substituted with at least one suitable substituent. 
     The term “alkynyl” used either alone or combined with other terms preferably stands for alkynyl having 2 to 6 or 2 to 5 carbon atoms. Examples include ethynyl, propargyl, 1-propynyl, but-3-ynyl or pent-4-ynyl. More preferred it stands for alkynyl having 2 to 4 carbon atoms. The alkinyl group can be unsubstituted or substituted with at least one suitable substituent. 
     A “heterocyclic group” preferably refers to a 5- or 6-membered heterocyclic group containing at least one of hetero atoms selected from N, O or S, and said heterocyclic group also refers to a condensed heterocyclic group which may be benzo-condensed. Typically a heterocyclic group contains no more than 4 nitrogens, 2 oxygens and 2 sulfur atoms. The cyclic group can be saturated, unsaturated or partially saturated. If not mentioned otherwise, then a heterocyclic group can be can be attached through any available carbon or heteroatom. Heterocyclic group include for example furyl, thienyl, pyrrolyl, isoxazolyl, pyrazolyl, oxazolyl, oxathiazolyl, imidazolyl, triazolyl, oxadiazolyl, thiadiazolyl, tetrazolyl, pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, triazinyl, indolyl, benzoxazolyl or quinolyl. The heterocyclic group can be unsubstituted or substituted with at least one suitable substituent. 
     The term “acylamino” refers to, for example, alkyl-carbonylamino, cycloalkyl-carbonylamino and benzoylamino, wherein the alkyl moiety may the same meaning as described for the aforementioned “alkyl”, and cycloalkyl moiety may have the same meaning as described below. The acylamino group can be unsubstituted or substituted with at least one suitable substituent. 
     Suitable substituents include for example the following chemical groups, namely amino, hydroxy, halogen, nitro, cyano, isocyano, mercapto, isothiocyanato, carboxy, carbonamide, SF5, amino-sulfonyl, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkinyl, monoalkyl-amino, dialkyl-amino, N-alkanoyl-amino, alkoxy, alkenyloxy, alkinyloxy, cycloalkoxy, cycloalkenyloxy, alkoxy-carbonyl, alkenyloxy-carbonyl, alkinyloxy-carbonyl, aryloxycarbonyl, alkanoyl, alkenyl-carbonyl, alkinyl-carbonyl, aryl-carbonyl, alkylthio, cycloalkylthio, alkenylthio, cycloalkenylthio, alkinylthio, alkylsulfenyl, alkylsulfinyl, including both enantiomeric forms of alkylsulfinyl, alkyl-sulfonyl, monoalkyl-aminosulfonyl, dialkyl-aminosulfonyl, alkylphosphinyl, alkylphosphonyl, including both enantiomeric forms of alkylphosphinyl and alkylphosphonyl, respectively, N-alkyl-aminocarbonyl, N,N-dialkyl-aminocarbonyl, N-alkanoyl-amino-carbonyl, N-alkanoyl-N-alkyl-aminocarbonyl, aryl, aryloxy, benzyl, benzyloxy, benzylthio, arylthio, arylamino, benzylamino, heterocyclyl and trialkylsilyl. Substituents which are further substituted, like for example alkoxyalkyl, alkylthioalkyl, alkylthioalkoxy, alkoxyalkoxy, phenethyl, benzyloxy, haloalkyl, haloalkoxy, haloalkylthio, haloalkanoyl, haloalkylcarbonyl, haloalkoxycarbonyl, haloalkoxyalkoxy, haloalkoxyalkylthio, haloalkoxyalkanoyl, haloalkoxyalkyl are also included. Preferred substituents are chloro, fluoro, bromo, iodo, NH 2 , NO 2 , CN, OH, SH and COOH. 
     Compounds according to the invention may be prepared by using generally known methods or by combining known methods with the preparation methods described herein. 
     For example, preparation method (a-1) and (a-2) can be carried out according to the method described in WO2007/021308. 
     Preparation Method (a-1) 
     Compounds of formula (I-i-1) as defined in embodiment I, wherein U represents oxygen and W′ stands for a group T 1  can be prepared by preparation methods (a-1), namely by reacting a compound of the formula (II-a) 
     
       
         
         
             
             
         
       
     
     wherein L 1  stands for halogen, alkylsulfonyloxy (e.g. methanesulfonyloxy), or arylsulfonyloxy (e.g. para-toluenesulfonyloxy), and L 2  stands for alkoxy (e.g. methoxy) or aryloxy (e.g. phenoxy), and wherein (X) m , (Y) n , A, R 1  and Q have the same meaning as described herein, particulary as described for embodiment I, I1 or I2, with a compound of the formula (III): 
       L 3 -T 1   (III)
 
     wherein L 3  stands for hydroxy, thiol or amino, and T 1  stands for either R 3  or R 4 ,
 
if appriopriate, in the presence of a diluent and/or a base to yield compounds of formula (I-i-1) as defined in embodiment I, wherein U represents oxygen and W′ stands for a group T 1 .
 
     In carrying out preparation method (a-1), 1 mole of a compound of formula (II-a) can be reacted with 1 to 2 moles of a compound of formula (III) in a diluent, such as toluene, and in the presence of a base, such as potassium carbonate, to obtain the desired compound. 
     Known compounds of formula (III) include for example water, hydrogen sulfide, ammonia, methylamine, ethylamine, benzylamine, 2-pyridinomethylamine, acetamide. Compounds of formula (I-i-2) as defined in embodiment I, wherein U represents oxygen and W′ stands for a group T 1  canalso be prepared by preparation method (a-1), namely by reacting a compound of the formula (II-b) 
     
       
         
         
             
             
         
       
     
     L 1  stands for halogen, alkylsulfonyloxy or arylsulfonyloxy, and L 2  stands for alkoxy (e.g. methoxy) or aryloxy (e.g. phenoxy), and wherein (X) m , (Y) n , A, R 1  and Q have the same meaning as described herein, particulary as described for embodiment I, I1 or I2, with a compound of formula (III). 
     Preparation Method (a-2) 
     Compounds of formula (I-l-1) as defined in embodiment L, wherein U represents oxygen and the two W′ stand for a group T 1  and H, can be prepared by preparation method (a-2), namely by reacting a compound of the formula (II-a) wherein L 1  stands for halogen, alkylsulfonyloxy or arylsulfonyloxy, and L 2  stands for alkoxy or aryloxy, and wherein (X) m , (Y) n , A, R 1  and Q have the same meaning as described herein, particulary as described for embodiment L, L1 or L2, with a compound of the formula (IV): 
       H 2 NHN-T 1   (IV)
 
     wherein T 1  stand for either R 3  or R 4 , and include, among other, methylhydrazine or ethylhydrazine, if appriopriate, in the presence of a diluent and/or a base to yield compounds of formula (I-l-1), wherein U represents oxygen and the one of the two W′ stands for a group T 1  and the other W′ stands for H. 
     In carrying out Preparation method (a-2), 1 mole of a compound of formula (II-a) can be reacted with 1 to 2 moles of a compound of formula (IV) in a diluent, such as toluene, and in the presence of a base, such as potassium carbonate to obtain the desired compound. 
     Preparation Method (b) 
     Compounds of formula (I-i-1) or (I-i-2) as defined in embodiment I, wherein U represents oxygen and the W′ stands for H can be prepared by preparation method (b), namely by reacting a compound of the formula (V-a) 
     
       
         
         
             
             
         
       
     
     wherein (X) m , (Y) n , A, R 1  and Q have the same meaning as described herein, particulary as described for embodiment I, I1 or I2, with
 
(i) a compound of the formula (VI-a):
 
       L 4 -T 1   (VI-a)
 
     wherein L 4  stands for halogen, alkylsulfonyloxy, arylsulfonyloxy or alkylcarbonyloxy, and T 1  stand for either R 3  or R 4 ; or with
 
(ii) a compound of the formula (VI-b)
 
       T 1 -O-T 1   (VI-b)
 
     wherein T 1  stands for R 3  or R 4 ; in case T 1  stands for a carbonyl-containing moiety, formula (VI-b) is an acid anhydride;
 
if appriopriate, in the presence of a diluent and/or a base to yield compounds of formula (I-i-1), wherein U represents oxygen and W′ stands for a group T 1 .
 
     Similarly, compounds of formula (I-i-2) can be prepared by reacting a compound of formula (V-b): 
     
       
         
         
             
             
         
       
     
     wherein (X) m , (Y) n , A, R 1  and Q have the same meaning as described herein, particulary as described for embodiment I, I1 or I2, with compounds of the formula (VI-a) or (VI-b). 
     In carrying out preparation method (b), 1 mole of a compound of formula (V-a) or (V-b) can be reacted with 1 to 10 moles of a compound of formula (VI-a) or (VI-b) in a diluent, for example toluene, in the presence of base to obtain the desired compound. 
     Compounds of formula (VI-a) and (VI-b) include, for example, acetic acid anhydride, acetyl chloride, methyl iodide, and benzyl bromide. 
     Similar preparation methods are described in WO99/05055, which methods are hereby incorporated. 
     Preparation Method (c) 
     Compounds of formula (I-h-1) as defined in embodiment H, wherein U represents N-T 1  can be prepared by preparation method (c), namely by 
     reacting a compound of the formula (VII-a) 
     
       
         
         
             
             
         
       
     
     wherein (X) m , (Y) n , A, R 1  and Q have the same meaning as described herein, particulary as described for embodiment H, H1 or H2, and wherein T 1  stands for either R 3  or R 4 , with alkyl-sulfonyl chloride or phenylsulfonyl chloride, if appropriate, in the presence of a base, and/or in the presence of a diluent. 
     Compounds of formula (I-h-2) as defined in embodiment H, wherein U represents N-T 1 , wherein T 1  is as defined herein, can be prepared by preparation method (c) by using compounds of the formula (VII-b) as a starting material 
     
       
         
         
             
             
         
       
     
     wherein (X) m , (Y) n , A, R 1  and Q have the same meaning as described herein, particulary as described for embodiment H, H1 or H2, and wherein T 1  stands for either R 3  or R 4 . 
     Preparation method (c) can be carried out according to the method described in Synlett (2006), 801-803 which is hereby incorporated by reference. 
     In carrying out Preparation method (c), 1 mole of a compound of formula (VII-a) can be reacted with 1 to 2 moles of methane sulfonyl chloride in a diluent, for example tetrahydrofuran, in the presence of a base to obtain the desired compound. 
     Preparation Method (d) 
     Compounds of formula (I-i-1) as defined in embodiment I, wherein U represents N—H and W′ stands for T 1  can be prepared by preparation method (d), namely by reacting a compound of formula (VIII-a) 
     
       
         
         
             
             
         
       
     
     wherein (X) m , (Y) n , A, R 1  and Q have the same meaning as described herein, particulary as described for embodiment I, I1 or I2,
 
with a compound of formula (IX)
 
       H 2 N-T 1   (IX)
 
     wherein T 1  stands for either R 3  or R 4 , if appropriate, in the presence of a base, and/or in the presence of a diluent. 
     Compounds of formula (I-i-2) as defined in embodiment I, wherein U represents N—H and W′ stands for T 1  can be prepared by preparation method (d), using a compound of formula (VIII-b) 
     
       
         
         
             
             
         
       
     
     wherein (X) m , (Y) n , A, R 1 , Q and L 1  have the same meaning as described herein as starting material. 
     Preparation method (d) can be carried out according to the methods described in U.S. Pat. No. 6,376,530, and which preparation methods are hereby incorporated by reference. 
     In carrying out preparation method (d), 1 to 2 moles of a compound of formula (VIII-a) can be reacted with 1-2 moles of a compound of formula (IX) in a diluent, for example acetonitrile, in the presence of potassium carbonate to obtain the desired compound. 
     Preparation Method (e) 
     Compounds of formula (I-i-1) as defined in embodiment I, wherein U represents N-T 1  and W′ stands for T 1  can be prepared by preparation method (e) namely by reacting a compound of the formula (X-a) 
     
       
         
         
             
             
         
       
     
     wherein (X) m , (Y) n , A, R 1  and Q have the same meaning as described herein, particulary as described for embodiment I, I1 or I2, with a compound of formula (VI-a) or (VI-b), if appropriate, in the presence of a base, and/or in the presence of a diluent. 
     Compounds of formula (I-i-2) as defined in embodiment I, wherein U represents N-T 1  and W′ stands for T 1  can be prepared by preparation method (e) using compounds of the formula (X-b): 
     
       
         
         
             
             
         
       
     
     wherein (X) m , (Y) n , A, R 1  and Q have the same meaning as described herein. 
     Compounds of formula (X-a) or (X-b) can be synthesized according to preparation method (d). 
     Compounds of formula (VI-a) or (VI-b) include for example acetic acid anhydride, acetyl chloride, methyl iodide, and benzyl bromide. 
     Preparation method (e) is a known organic synthetic reaction. In the presence of an appropriate base a substitution reaction can occur. 
     In carrying out preparation method (e), 1 mole of a compound of formula (X) can be reacted with 1 to 1.5 moles of a compound of formula (VI) in a diluent, for example tetrahydrofuran, in the presence of pyridine to obtain a desired compound. 
     Preparation Method (f) 
     Compounds of formula (I-j-1) as defined in embodiment J, wherein W′ stands for T 1  can be prepared by preparation method (f), namely by reacting a compound of the formula (XI) 
     
       
         
         
             
             
         
       
     
     wherein (X) m , (Y) n , A, R 1  and Q have the same meaning as described herein, particulary as described for embodiment J, J1 or J2, with a compound of formula (III), if appropriate, in the presence of a base, and/or in the presence of a diluent. 
     Compounds aof formula (III) are for example methylamine, ethylamine, benzylamine, 2-pyridinomethylamine or acetamide. 
     Preparation method (f) can be carried out according to the methods disclosed in Tetrahedron Lett., 2005, 5927-5930 which are hereby incorporated by reference. 
     In carrying out preparation method (f), 1 mole of a compound of formula (XI) can be reacted with 1 to 2 moles of a compound of formula (III) in a diluent, for example tetrahydrofuran, in the presence of 1 to 2 moles of sodium hydride as the base, to obtain the desired product. 
     Preparation Method (g) 
     Compounds according to the invention wherein A is oxygen can be prepared according to preparation methods (g) and (h), namely by 
     reacting a compound of the formula (XII) 
     
       
         
         
             
             
         
       
     
     wherein (X) m , R 1  and Q have the same meaning as described herein, particularly as described in the embodiments A, B, C or L, L1 or L2,
 
with a compound of the following formula (XIII):
 
     
       
         
         
             
             
         
       
     
     wherein W 1  to W 4  and (Y) n  have the same meaning as described herein, in the presence of inert diluents, and, if appropriate in the presence of a base. 
     Preparation method (g) can be carried out according to the methods disclosed in WO2004/018410, WO2005/085216, Tetrahedron, 2000, Vol 56, 1057-1064. 
     In carrying out preparation method (g), 1 mole of a compound of formula (XIII) can be reacted with 1 to 2 moles of a compound of formula (XII) and with 1 mole to a slightly excessive amount of base in a diluent, for example DMF, to obtain the desired compound. 
     Preparation Method (h) 
     Compounds according to the invention wherein A is nitrogen or oxygen can be prepared according to preparation method (h), namely by 
     reacting a compound of the formula (XIV) 
     
       
         
         
             
             
         
       
     
     wherein (X) m , (Y) n , A, R 1  and Q have the same meaning as described herein, particularly as described in the embodiments A, B, C, H1, H2, and H3, and wherein W 1  to W 4  and (Y) n  have the same meaning as described herein, with
 
(i) a compound of the formula (XV):
 
       H 2 NHN—R 2   (XV)
 
     or a hydrochloride acid salt thereof, wherein R 2  has the same meaning as described herein, to form a pyrazoline ring at the appropriate position; or
 
(ii) a hydroxyamine or a hydrochloride acid salt thereof to form an isoxazoline ring at the appropriate position;
 
if appropriate in the presence of a base and optionally in the presence of a diluent.
 
     Examples of the compound of formula (XV) include hydrazine, methylhydrazine and ethylhydrazine. 
     Compounds according to the invention wherein A is CH 2  can be prepared according to preparation methods (i) and (j). 
     Preparation Method (i) 
     Shifting an imino double bond in compounds of formula (XVI): 
     
       
         
         
             
             
         
       
     
     wherein (X) m , A, R 1  and Q have the same meaning as described herein, particularly as described in the embodiments A, B, C, H1, H2, and H3, and wherein W 1  to W 4  and (Y) n  have the same meaning as described herein,
 
if appropriate, in the presence of a base, and optionally in the presence of a diluent.
 
     Preparation method (i) can be carried out according to the methods disclosed in Japanese Patent Application Laid-Open 2007-91708 and Chem. Lett., 1985, 1601-1604 which are hereby incorporated by reference. 
     In carrying out preparation method (i), 1 mole to a slightly excessive amount of base can be reacted with 1 mole of a compound of formula (XVI) in a diluent, for example tetrahydrofuran, to obtain a desired compound of formula (I). 
     Preparation Method (j) 
     Reacting a compound of formula (XII) as defined above with a compound of the following formula (XXX): 
     
       
         
         
             
             
         
       
     
     wherein R 1 ′, R 2 ′ and R 3 ′ each independently represent C 1-12  alkyl, or phenyl; R 4 ′ represents hydrogen; or is selected among C 1-12  alkyl, C 1-12  alkenyl, C 1-12  alkynyl and benzyl; and
 
W 1  to W 4  and (Y) n  have the same meaning as described herein, if appropriate, in the presence of a fluoride reagent, such as potassium fluoride, tetramethylammonium fluoride, tetraethylammonium fluoride, or tetrabutylammonium fluoride.
 
     For carrying out preparation method (j) 1 mole of a compound of formula (XII) relative to 1 mole of compound of formula (XXX) can be reacted with 0.1 mole of a fluoride reagent in a diluent, for example THF, to obtain a desired compound of formula (I). 
     Preparation method (j) can be carried out according to the methods described in J. Org. Chem., Vol. 52, 1027-1035, 1987 which is hereby incorporated by reference. 
     The preparation methods can be illustrated by the following reaction schemes, by way of examples. 
     
       
         
         
             
             
         
       
     
     Here, methyl 2-(bromomethyl)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]benzoate and ammonia are used as starting material. 
     
       
         
         
             
             
         
       
     
     Here, methyl 2-(bromomethyl)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]benzoate and ethyl hydrazine are used as starting material. 
     
       
         
         
             
             
         
       
     
     Here, 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2,3-dihydro-1H-isoindol-1-one and an acetic anhydride are used as starting material. 
     
       
         
         
             
             
         
       
     
     Here, 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-(hydroxymethyl)-N-methylbenzamide, methanesulfonyl chloride and triethylamine are used as starting material. 
     
       
         
         
             
             
         
       
     
     Here, 2-(bromomethyl)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]benzonitrile and 1-(pyridin-2-yl)methaneamine are used sarting material. 
     
       
         
         
             
             
         
       
     
     Here, 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-imine, acetyl chloride and tiretylamine are used as starting material. 
     
       
         
         
             
             
         
       
     
     Here, 3-[3,4-bis(bromomethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazole, acetamide and sodium hydride are used as starting material. 
     
       
         
         
             
             
         
       
     
     Here, 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene and N-hydroxy-1,3-dihydro-2-benzofuran-5-carboxylmidylchloride are used as starting material. 
     
       
         
         
             
             
         
       
     
     Here, 5-[3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-enoyl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-one and hydroxyamine are used as starting material. 
     
       
         
         
             
             
         
       
     
     Here, 5-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-2-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-one is used as starting material. 
     
       
         
         
             
             
         
       
     
     Here, 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene and methyl 1-[(tert-butoxycarbonyl-) amino]-N-[(trimethylsilyl)methyl]-2,3-dihydro-1H-inden-5-carboimide thioate are used as starting material. 
     Known compounds of formulae (II-a) and (II-b) can be obtained by reacting compounds of formula (XVII-a) or (XVII-b) 
     
       
         
         
             
             
         
       
     
     wherein (X) m , (Y) n , A, R 1 , Q and L 2  have the same meaning as described herein, with a halogenating agent, such as chlorine, bromine, iodine, N-chlorosuccinimide, N-bromosuccinimide, N-iodosuccinimide, 1,3-dichloro-5,5-hydantoin, 1,3-dibromo-5,5-dimethylhydantoin, benzyl trimethyl ammonium tetrachloroiodate and sodium hypochlorite, if appropriate, in the presence of a catalyst (e.g. AIBN (2,2′-azabisisobutyronitrile) or benzoyl peroxide). 
     Compounds of formulae (II-a) or (II-b) are for example methyl 2-(bromomethyl)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]benzoate, methyl 2-(bromomethyl)-5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]benzoate, methyl 2-(bromomethyl)-4-[5-(3,5-dichlorophenyl)-1-methyl-5-(trifluoromethyl)-4,5-di-hydro-1H-pyrazol-3-yl]benzoate, and methyl 2-(bromomethyl)-5-[5-(3,5-dichlorophenyl)-1-methyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-yl]benzoate. 
     Compounds of formula (V-a) or (V-b) can be obtained through preparation method (a-1) and include 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-isoindol-1-one, 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2,3-dihydro-1H-isoindol-1-one, 5-[5-(3,5-dichlorophenyl)-1-methyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-yl]-2,3 dihydro-1H-isoindol-1-one, and 6-[5-(3,5-dichlorophenyl)-1-methyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-yl]-2,3-dihydro-1H-isoindol-1-one. 
     Compounds of formula (VII-a) or (VII-b) include for example 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-(hydroxymethyl)-N-methylbenzamide, 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-(hydroxymethyl)-N-methylbenzamide, 4-[5-(3,5-dichlorophenyl)-1-methyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-yl]-2-(hydroxymethyl)-N-methylbenzamide, and 5-[5-(3,5-dichloro-phenyl)-1-methyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-yl]-2-(hydroxymethyl)-N-methyl-benzamide. 
     Compounds of formula (VII-a) or (VII-b) can be obtained by reacting a compound of formula (XIX-a) or (XIX-b), which can be obtained by using preparation method (a), 
     
       
         
         
             
             
         
       
     
     wherein (X) m , (Y) n , A, R 1  and Q have the same meaning as described herein, with a compound of formula (IX), if appropriate, in the presence of a base. 
     Compounds of formula (XIX-a) and (XIX-b) can be obtained according to preparation method (a) and according to the method disclosed in EP-A-1 362 856. For example by reacting compounds of formula (II-a) or (II-b) with sodium acetate to give the compounds of the formula (XX-a) and (XX-b), respectively 
     
       
         
         
             
             
         
       
     
     wherein (X) m , (Y) n , A, R 1 , Q and L 2  have the same meaning as described herein, following reation with a base in alcohol. 
     Compounds of formula (XIX-a) or (XIX-b) include for example 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-benzofuran-1(3H)-one, 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-benzofuran-1(3H)-one, 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-benzofuran-1(3H)-one, 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-benzofuran-1(3H)-one. 
     Compounds of formula (ω-a) and (XX-b) include for example Methyl 2-[(acetyloxy)methyl]-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]benzoate, Methyl 2-[(acetyloxy)methyl]-5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]benzoate, Methyl 2-[(acetyloxy)methyl]-4-[5-(3,5-dichlorophenyl)-1-methyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-yl]benzoate, Methyl 2-[(acetyloxy)methyl]-5-[5-(3,5-dichlorophenyl)-1-methyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-yl]benzoate. 
     Compounds of formula (VIII-a) or (VIII-b) can be obtained according to the preparation method described herein for the preparation of compounds of formula (II-a). 
     Compounds of formula (VIII-a) or (VIII-b) include for example 2-(bromomethyl)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]benzonitrile, 2-(bromomethyl)-5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-soxazol-3-yl]benzonitrile, 2-(bromomethyl)-4-[5-(3,5-dichlorophenyl)-1-methyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-yl]benzonitrile, and 2-(bromomethyl)-5-[5-(3,5-dichlorophenyl)-1-methyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-yl]benzonitrile. 
     Compounds of formula (IX) include for example methylamine, ethylamine, benzylamine, 2-pyridinomethylamine, and acetamide. 
     Compounds of formula (X-a) or (X-b) include for example 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-imine,
     6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-imine,   5-[5-(3,5-dichlorophenyl)-1-methyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-imine, and   6-[5-(3,5-dichlorophenyl)-1-methyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-imine.   

     Compounds of formula (XVII-a) and (XVII-b) can be synthesized according to known methods (cf. WO2004/018410, WO2005/085216, Tetrahedron, 2000, Vol 56, 1057-1064, or WO2007/074789) and/or via preparation method (h) by using the compounds of formula (XVIII-a) or (XVIII-b) as starting material 
     
       
         
         
             
             
         
       
     
     wherein (X) m , (Y) n , R 1  and Q have the same meaning as described herein, and reacting these compounds with a compound of formula (XV) or the hydrochloride acid salt therefrom, or, alternatively, with hydroxyamine or the hydrochloride acid salt therefrom, if appropriate, in the presence of a base. 
     Compounds of formula (XVII-a) or (XVII-b) are for example methyl 2-methyl-4-[5-(3,5-dichloro-phenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]benzoate, methyl 2-methyl-5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]benzoate, methyl 2-methyl-4-[5-(3,5-dichlorophenyl)-1-methyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-yl]benzoate, and methyl 2-methyl-5-[5-(3,5-dichlorophenyl)-1-methyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazol-3-yl]benzoate. 
     Compounds of formula (XI) can be synthesized by diluting a compound of the formula (XXI) 
     
       
         
         
             
             
         
       
     
     wherein (X) m , (Y) n , A, R 1  and Q have the same meaning as described herein, with an appropriate diluent, for example dichloroethane, and then treating the mixture with a halogenating agent such as N-bromosuccinimide. 
     Compounds of formula (XI) include for example 3-[3,4-bis(bromomethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole, and 3-[3,4-bis(bromomethyl)phenyl]-5-(3,5-dichlorophenyl)-1-methyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazole. 
     Compounds of formula (XXI) can be obtained based on the synthesizing route described for compounds of formula (XVII-a) or (XVII-b). Compounds of formula (XXI) include for example 5(3,5-dichlorophenyl)-3-(3,4-dimethylphenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole, 5-(3,5-dichlorophenyl)-3-(3,4-dimethylphenyl)-1-methyl-5-(trifluoromethyl)-4,5-dihydro-1H-pyrazole. 
     Compounds of formula (XII) are also described in The Journal of Organic Chemistry, 1991, Vol 56, 7336-7340, ibid, 1994, Vol 59, 2898-2901, Journal of Fluorine Chemistry, 1999, Vol 95, 167-170, or WO2005/05085216. 
     Compounds of formula (XII) include for example [1-(trifluoromethyl)vinyl]benzene, 1,3-difluoro-5-[1-(trifluoromethyl)vinyl]benzene, 1-chloro-3-[1-(trifluoromethyl)vinyl]benzene, 1,3-dichloro-5-[1-(trifluoromethyl)vinyl]benzene, 1-trifluoromethyl-3-[1-(trifluoromethyl)vinyl]benzene, 1-trifluoromethyl-4-[1-(trifluoromethyl)vinyl]benzene, 1,3-bis(trifluoromethyl)-5-[1-(trifluoro-methyl)vinyl]benzene, 1,3-dibromo-5-[1-(trifluoromethyl)vinyl]benzene, and 1,2,3-trichloro-5-[1-(trifluoromethyl)vinyl]benzene, 1-fluoro-2-(trifluoromethyl)-4-[1-(trifluoromethyl)vinyl]benzene. 
     Compounds of formula (XIII) can be obtained by reacting compounds of formula (XXII) 
     
       
         
         
             
             
         
       
     
     wherein W 1  to W 4  and (Y), have the same meaning as described herein, with a halogenating agent. 
     Compounds of formula (XXII) can be obtained by reacting compounds of the formula (XXIII) 
     
       
         
         
             
             
         
       
     
     wherein W 1  to W 4  and (Y) n  have the same meaning as described herein, with hydroxyamine or a salt thereof. 
     Compounds of formula (XXIII) include for example 1H-indol-5-carbaldehyde, t-butyl 5-formyl-1H-indol-1-carboxyate, 1H-indol-6-carbaldehyde, t-butyl 6-formyl-1H-indol-1-carboxyate, 2,3-dihydro-1H-indol-5-carbaldehyde, t-butyl 5-formyl-2,3-dihydro-1H-indol-1-arboxyate, 1-oxo-2,3-dihydro-1H-inden-5-carbaldehyde, 5-oxo-5,6,7,8-tetrahydronaphthalen-2-carbaldehyde, 2,3-dihydro-1-benzofuran-5-carbaldehyde, 1,3-benzdioxol-5-carbaldehyde, 1,4-benzodioxan-6-carbaldehyde, 1-oxo-1,3-dihydro-2-benzo-furan-5-carbaldehyde, and 1-oxo-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-5-carbaldehyde. 
     Reaction Scheme 11 and 12—Methods for the Preparation of Compounds of Formula (XXIII): 
     
       
         
         
             
             
         
       
     
     (wherein, Boc represents a t-butoxycarbonyl group, MeCN represents acetonitrile, cat.DMAP represents a catalytic amount of 4-dimethylaminopyridine, Pd—C represents palladium charcoal and ETOH represents ethanol). 
     
       
         
         
             
             
         
       
     
     (wherein, Ac represents an acetyl group, DPPP represents 1,3-bis(diphenylphosphino)propane, Et3N represents triethylamine, DMF represents dimethylformamide, and Me represents a methyl group). 
     5-Oxo-5,6,7,8-tetrahydronaphthalen-2-carbaldehyde can be synthesized in the same manner as the method of Scheme 12, by using 6-bromo-3,4-dihydronaphthalen-1(2H)-one as starting material. 
     Halogenating agents which are suitable for the preparation of compounds of the formula (XIII) include chlorine, bromine, iodine, N-chlorosuccinimide, N-bromosuccinimide, N-iodosuccinimide, 1,3-dichloro-5,5-hydantoin, 1,3-dibromo-5,5-dimethylhydantoin, benzyl trimethyl ammonium tetrachloroiodate, and sodium hypochlorite. 
     Compounds of formula (XXIII) include for example N-hydroxy-1H-indol-5-carboxyImidoyl chloride, t-butyl 5-[chloro(hydroxyimino)methyl]-1H-indol-1-carboxyate, t-butyl-5-[chloro-(hydroxyimino)methyl]-2,3-dihydro-1H-indol-1-carboxyate, N-hydroxy-1H-indol-6-carboxy-imidoyl chloride, N-hydroxy-2,3-dihydro-1-benzofuran-5-carboxyImidoyl chloride, N-hydroxy-1,3-benzodioxol-5-carboxyImidoyl chloride, N-hydroxy-2,3-dihydro-1,4-benzo-dioxin-6-carboxyImidoyl chloride, N-hydroxy-1-oxo-1,3-dihydro-2-benzofuran-5-carboxyImidoyl chloride, N-hydroxy-1-oxo-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-5-carboxyImidoyl chloride and N-hydroxy-1-oxo-2,3-dihydro-1H-inden-5-carboxylmidyl chloride. 
     With respect to preparation method (g), once an isoxazoline ring is constructed, substitution with various substituents can be made. Reaction scheme 13 and Reaction scheme 14 show synthetic method examples to introduce substituents. 
     
       
         
         
             
             
         
       
     
     (wherein, c.HCl represents concentrated hydrochloric acid, Et represents an ethyl group, heat represents a heating treatment and THF represents tetrahydrofuran). 
     
       
         
         
             
             
         
       
     
     (wherein, Me represents a methyl group, DEAD represents diethyl azodicarboxyate, Ph represents a phenyl group, Et represents an ethyl group, and THF represents tetrahydrofuran). 
     Preparation method (g) can be applied to the synthetic method comprising reacting the compounds of formula (XXXI) which fall under the general formula (XXXI-a): 
     
       
         
         
             
             
         
       
     
     wherein R 2 , W 1  to W 4  and (Y) n  have the same meaning as described herein, with the compounds of formula (XII) described herein. 
     The invention is further directed to useful intermediate compounds of formula (XXXI-a) for the preparation of compounds according the invention 
     
       
         
         
             
             
         
       
     
     wherein T 2  stands for O, N—OH and N—NH—R 2 , and W 1  to W 4  and (Y) n  have the same meaning as defined herein. 
     Compounds of the formula (XXII), (XXIII) and (XXXII), which are useful intermediates for the preparation of compounds according to the invention, are represented by the formula (XXXI-a). 
     Compounds of formula (XXXI) can be prepared using the same preparation methods as described for compounds of formula (XIII), however, starting with (XXXII). 
     
       
         
         
             
             
         
       
     
     The compounds of formula (XIV), which are useful intermediates for the preparation of compounds according to the invention, can be obtained by reacting compounds of formula (XXIV) 
     
       
         
         
             
             
         
       
     
     wherein W 1  to W 4 , (X) m , (Y) n , R 1  and Q have the same meaning as described herein with thionyl chloride. 
     Compounds of formula (XXIV) are for example 3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxy-1-(1H-indol-5-yl)butan-1-one, 5-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutanoyl]-2-benzofuran-1(3H)-one, 5-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-3-hydroxybutanoyl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-one, 3-(3,4,5-trichloro-phenyl)-4,4,4-trifluoro-3-hydroxy-1-(1H-indol-5-yl)butan-1-one, 5-[3-(3,4,5-trichlorophenyl)-4,4,4-trifluoro-3-hydroxybutanoyl]-2-benzofuran-1(3H)-one, 5-[3-(3,4,5-trichlorophenyl)-4,4,4-trifluoro-3-hydroxybutanoyl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-one, 3-[3,5-bis(trifluoromethyl)phenyl]-4,4,4-trifluoro-3-hydroxy-1-(1H-indol-5-yl)butan-1-one, 5-{3-[3,5-bis(trifluoromethyl)phenyl]-4,4,4-trifluoro-3-hydroxybutanoyl}-2-benzofuran-1(3H)-one, 5-{3-[3,5-bis(trifluoromethyl)phenyl]-4,4,4-trifluoro-3-hydroxybutanoyl}-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-one. 
     Compounds of formula (XXIV) can be synthesized according to a method disclosed in Zhurnal Organicheskoi Khimii, Vol 28 (No. 3), 518-526, namely by reacting the compound represented by the formula (XXV) 
     
       
         
         
             
             
         
       
     
     (wherein (X) m , Q and R 1  have the same meaning as described herein) with the compound represented by the following formula (XXVI): 
     
       
         
         
             
             
         
       
     
     (wherein W 1  to W 4  and (Y) n  have the same meaning as described herein). 
     Compounds of formula (XXV) include for example trifluoroacetophenone, 3′,5′-dichloro-2,2,2-trifluoroacetophenone, 3′,4′-dichloro-2,2,2-trifluoroacetophenone, 3′,4′,5′-trichloro-2,2,2-trifluoroacetophenone, 3′-fluoro-2,2,2-trifluoroacetophenone, 3′-chloro-2,2,2-trifluoroacetophenone, 3′-bromo-2,2,2-trifluoroacetophenone, 3′-iodo-2,2,2-trifluoroaceto-phenone, 3′-nitro-2,2,2-trifluoroacetophenone, 3′-cyano-2,2,2-trifluoroacetophenone, 3′-(trifluoro-methyl)-2,2,2-trifluoroacetophenone, and 3′,5′-bis(trifluoromethyl)-2,2,2-trifluoroacetophenone. 
     Compounds of formula (XXVI) include for example 5-acetylindane, 6-acetyltetraline, 3′,4′-(methylenedioxy)acetophenone, 1,4-benzodioxane-6-ylmethyl ketone, 5-acetyl-2,3-dihydro-1-benzofuran, 5-acetyl-1H-indole, 5-acetyl-2-benzofuran-1(3H)-one, and 5-acetyl-2-(pyridin-2-yl-methyl)-2,3-dihydro-1H-isoindol-1-one. 
     Compounds of formula (XIV) include for example 3-(3,5-dichlorophenyl)-4,4,4-trifluoro-1-(1H-indol-5-yl)but-2-ene-1-one, 5-[3-(3,5-dichlorophenyl)-4,4,4-trifluoro-2-enoyl]-2-benzofuran-1(3H)-one, 5-[3-(3,5-dichlorophenyl)-4,4,4-trifluorobut-2-enoyl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-one, 3-(3,4,5-trichlorophenyl)-4,4,4-trifluoro-1-(1H-indol-5-yl)but-2-ene-1-one, 5-[3-(3,4,5-trichlorophenyl)-4,4,4-trifluoro-2-enoyl]-2-benzofuran-1(3H)-one, 5-[3-(3,4,5-trichlorophenyl)-4,4,4-trifluorobut-2-enoyl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-one, 3-[3,5-bis(trifluoromethyl)phenyl]-4,4,4-trifluoro-1-(1H-indol-5-yl)but-2-ene-1-one, 5-{3-[3,5-bis(trifluoromethyl)phenyl]-4,4,4-trifluoro-2-enoyl}-2-benzofuran-1(3H)one, and 5-{3-[3,5-bis(trifluoromethyl)phenyl]-4,4,4-trifluorobut-2-enoyl}-2-(pyridin-2-yl-methyl)-2,3-dihydro-1H-isoindol-1-one. 
     Preparation method (h) can also be used to prepare compounds of formula (XVII-a) and (XVII-b) from the compounds of formula (XVIII-a) and (XVIII-b). 
     Compounds of formula (XVI) can be synthesized according to the method disclosed in EP-A-1 538 138, namely by reacting the compound represented by the formula (XXVII): 
     
       
         
         
             
             
         
       
     
     (wherein W 1  to W 4  and (Y), have the same meaning as described herein).
 
with the compound of formula (XII), if appropriate, in the presence of a metal catalyst (e.g. copper(II) oxide).
 
     Representative examples of the compound of formula (XVI) include 5-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-2-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-one, N-[5-[4-(3,5-dichlorophenyl)-4-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-2-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-yliden]acetamide, and 4-(3,5-dichlorophenyl)-2-(1,3-dihydro-2-benzofuran-5-yl)-4-(trifluoromethyl)-3,4-dihydro-2H-pyrrole. 
     The compound of formula (XXVII) can be synthesized according to the method disclosed in Chem. Lett., 1977, 697-698, or by reacting compounds of the formula (XXVIII) 
     
       
         
         
             
             
         
       
     
     (wherein W 1  to W 4  and (Y) n  have the same meaning as described herein) with ethyl formate, to obtain the compound of the formula (XXIX): 
     
       
         
         
             
             
         
       
     
     followed by steps of halogenation and dehydrohalogenation. 
     Compounds of formula (XXVI) include for example 5-(isocyanomethyl)-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-one, N-[5-(isocyanomethyl)-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-yliden]acetamide, and 1,3-dihydro-2-benzofuran-5-ylmethylisocyanide. 
     
       
         
         
             
             
         
       
     
     (wherein DMF represents N,N-dimethylformamide and dioxane represents 1,4-dioxane). 
     Compounds of formula (XXIX) include for example N-{[1-oxo-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-5-yl]methyl}formamide, N-[5-[(formylamino)methyl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-yliden]acetamide. 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     (wherein, Me stands for methyl, (Ph 3 P) 4 Pd stands for tetrakistriphenylphosphine palladium, c.HCl stands for concentrated hydrochloric acid, Ac stands for an acetyl group, reflux stands for a heating treatment, EDC stands for 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide, DMAP stands for dimethylaminopyridine, TMS stands for a trimethylsilyl group, Boc rep stands for a t-butoxycarbonyl group, toluene stands for toluene, Lawesson reagent stands for 2,4-bis(4-methoxyphenyl)-1,3-dithia-2,4-diphosphetane-2,4-disulfide, BuO-t represents a t-butoxy group, THF stands for tetrahydrofuran, and t-BuOK stands for t-butoxy potassium). 
     Compounds of formula (XXX) include for example methyl 1-[(t-butoxycarbonyl)amino-]-N-[(trimethylsilyl)methyl]-2,3-dihydro-1H-inden-5-carboimide thioate, methyl 5-[(t-butoxycarbonyl)amino]-N-[(trimethylsilyl)methyl]-5,6,7,8-tetrahydro-naphthalen-2-carboimide thioate, methyl 5-[(t-butoxycarbonyl)amino]-N-[(trimethylsilyl)-methyl]naphthalen-2-carboimide thioate, methyl 6-[(t-butoxycarbonypamino]-N-[(trimethylsilyl)-methyl]naphthalen-2-carboimide thioate. 
     Methyl 5-[(t-butoxycarbonyl)amino]-N-[(trimethylsilyl)methyl]-5,6,7,8-tetrahydronaphthalen-2-carboimide thioate can be synthesized according to the method shown in reaction scheme 16, by using 6-bromo-3,4-dihydronaphthalen-1(2H)-one as a starting material. 
     The compounds of formula (XXX) are intermediates for the preparation of compounds according to the invention. Namely, as compounds according to the invention can be prepared by reacting a compound of formula (XII) with compounds of formula (XXX) in the presence of a fluorine reagent if R 4 ′ does not stands for H. In case that R 4 ′ stands for H, the reaction can be carried out in a one pot reaction by firstly adding an alkylating reagent, such as methyl iodide and then adding an appropriate fluorine reagent. 
     With respect to preparation method (j), once a pyrroline ring part is constructed, substitution with various substituents can be made. 
     Reaction Scheme 17 Shows a Synthetic Method Example for Introducing Various Substituents on Condensed-Ring Moiety. 
     
       
         
         
             
             
         
       
     
     (wherein, Bu-t represents a t-butyl group, Et represents an ethyl group and THF represents tetrahydrofuran). 
     Appropriate diluents for the preparation methods disclosed herein, particularly for preparation methods (a-1), (a-2), (b), (c), (d), (e), (f), (g), (i) include aliphatic, alicyclic, and aromatic hydrocarbons (which may be chlorinated in some cases), for example, pentane, hexane, cyclo-hexane, petroleum ether, ligroin, benzene, toluene, xylene, chlorobenzene, dichlorobenzene and the like; ethers, for example, ethyl ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran (THF), diethylene glycol dimethyl ether (DGM) and the like; ketones, for example, acetone, methyl ethyl ketone (MEK), methyl isopropyl ketone, methyl isobutyl ketone (MIBK) and the like; nitriles, for example, acetonitrile, propionitrile and the like; esters, for example, ethyl acetate, amyl acetate and the like; acid amides, for example, dimethylformamide (DMF), dimethylacetamide (DMA), N-methylpyrrolidone, 1,3-dimethyl-2-imidazolidinone, hexamethylphosphoric triamide (HMPA) and the like; sulfones and sulfoxides, for example, dimethylsulfoxide (DMSO), sulforane and the like; and bases, for example, pyridine and the like. 
     Appropriate diluents for the preparation method (j) include for example aliphatic, alicyclic, and aromatic hydrocarbons (which may be chlorinated in some cases), for example, pentane, hexane, cyclohexane, petroleum ether, ligroin, benzene, toluene, xylene, dichloromethane, chloroform, carbon tetrachloride, 1,2-dichloroethane, chlorobenzene, dichlorobenzene and the like; ethers, for example, ethyl ether, methyl ethyl ether, isopropyl ether, butyl ether, dioxane, dimethoxyethane (DME), tetrahydrofuran (THF), diethylene glycol dimethyl ether (DGM) and the like; ketones, for example, acetone, methyl ethyl ketone (MEK), methyl isopropyl ketone, methyl isobutyl ketone (MIBK) and the like; nitriles, for example, acetonitrile, propionitrile, acrylonitrile and the like; esters, for example, ethyl acetate, amyl acetate and the like. 
     Appropriate bases for the preparation methods disclosed herein, particularly for preparation methods (a-1), (a-2), (b), (c), (d), (e), (f), (g) include inorganic bases such as hydrides, hydroxides, carbonates and bicarbonates of alkaline metals and alkaline earth metals, for example, sodium hydride, lithium hydride, sodium hydrogen carbonate, potassium hydrogen carbonate, sodium carbonate, potassium carbonate, lithium hydroxide, sodium hydroxide, potassium hydroxide, calcium hydroxide and the like; and organic bases such as alcoholate, tertiary amines, dialkyl-aminoanilines and pyridines, for example, triethylamine, 1,1,4,4-tetramethylethylenediamine (TMEDA), N,N-dimethylaniline, N,N-diethylaniline, pyridine, 4-dimethylaminopyridine (DMAP), 1,4-diazabicyclo[2,2,2]octane (DABCO), and 1,8-diazabicyclo[5,4,0]undec-7-ene (DBU) and the like. 
     Further appropriate bases, particularly for the preparation methods (i) and (h) are alkaline metal bases, such as for example, sodium carbonate, potassium carbonate, sodium hydrogen carbonate, potassium hydrogen carbonate, sodium acetate, potassium acetate, sodium methoxide, sodium ethoxide, potassium-tert-butoxide and the like; and an organic base such as triethylamine, diisopropylethylamine, tributylamine, N-methylmorpholine, N,N-dimethylaniline, N,N-diethylaniline, 4-tert-butyl-N,N-dimethylaniline, pyridine, picoline, lutidine, diazabicyclo-undecene, diazabicyclooctane, imidazole and the like. 
     The preparation methods disclosed herein, particularly the preparation methods (a-1), (a-2), (b), (c), (d), (e), (f), (g), (i) can be carried out within a substantially broad range of temperatures, i.e. in range of −78° C. to about 200° C. Generally, it can be carried out at a temperature in the range of about 10 to about 150° C., preferably in the range of about 30 to about 120° C. They can be carried out at any pressure, i.e. at a pressure of about 1013 mbar, at a pressure lower than 1013 mbar and a pressure higher than 1013 mbar. Reaction time may vary from about 0.1 hours to about 72 hours, preferably from 1 to 24 hours. 
     Preparation method (j) can be carried out within a substantially broad range of temperatures. generally, it can be carried out at a temperature in a range of about −78 and about 100° C., preferably in a range of about −10 and about 50° C. In addition, although the above-described reaction is preferably carried out at normal pressure, it can also be carried out under increased or reduced pressure. Reaction time is from 0.1 to 10 hours, and preferably from 1 to 5 hours. 
     The compounds according to the present invention show a potent insecticidal action and can therefore be used as an insecticide. Furthermore, the compounds according to the present invention exhibit a strong control effect against harmful insects, without imposing any harmful side effects of drug to cultivated plants. 
     The compounds of the present invention can thus be used for the control of a wide range of pest species, for example, harmful sucking insects, chewing insects, as well as other plant parasitic pests, storage insects, hygiene pests and the like, and can be applied for the purpose of disinfestations and extermination thereof. Harmful animal pest are for example: 
     As for insects, coleopterans, for example,  Callosobruchus chinensis, Sitophilus zeamais, Tribolium castaneum, Epilachna vigintioctomaculata, Agriotes fuscicollis, Anomala rufocuprea, Leptinotarsa decemlineata, Diabrotica  spp.,  Monochamus alternatus, Lissorhoptrus oryzophilus, Lyctus bruneus, Aulacophora femoralis ; lepidopterans, for example,  Lymantria dispar, Malacosoma neustria ),  Pieris rapae, Spodoptera litura, Mamestra brassicae, Chilo suppressalis ),  Pyrausta nubilalis, Ephestia cautella, Adoxophyes orana, Carpocapsa pomonella, Agrotisfucosa, galleria mellonella, Plutella maculipennis, Heliothis virescens, Phyllocnistis citrella; hemipterans , for example,  Nephotettix cincticeps, Nilaparvata lugens, Pseudococcus comstocki, Unaspis yanonensis, Myzus persicas, Aphis pomi, Aphis gossypii, Rhopalosiphum pseudobrassicas, Stephanitis nashi, Nezara  spp.,  Trialeurodes vaporariorm, Psylla  spp.; thysanopterans, for example,  Thrips palmi, Frankinella occidental ; orthopterans, for example,  Blatella germanica, Periplaneta americana, gryllotalpa Africana, Locusta migratoria migratoriodes ; isopterans, for example,  Reticulitermes speratus, Coptotermes formosanus ; dipterans, for example,  Musca domestica, Aedes aegypti, Hylemia platura, Culex pipiens, Anopheles sinensis, Culex tritaeniorhynchus, Liriomyza trifolii.    
     As for acari, for example,  Tetranychus cinnabarinus, Tetranychus urticae, Panonychus citri, Aculops pelekassi, Tarsonemus  spp. 
     As for nematodes, for example,  Meloidogyne incognita, Bursaphelenchus lignicolus Mamiya et Kiyohara, Aphelenchoides besseyi, Heterodera glycines, Pratylenchus  spp. 
     Additionally, the compounds according to the present invention show a good plant tolerance and favourable toxicity to warm-blooded animals and being tolerated well by the environment, and thus are suitable for protecting plants and plant parts. 
     Application of the compounds of the invention may result in increasing the harvest yields, improving the quality of the harvested material. Additionally, the compounds can be used for controlling animal pests, in particular insects, arachnids, helminths, nematodes and molluscs, which are encountered in agriculture, in horticulture, the field of veterinary medicine, in forests, in gardens and leisure facilities, in the protection of stored products and of materials, and in the hygiene sector. They may be preferably employed as plant protection agents. They are active against normally sensitive and resistant species and against all or some stages of development. 
     These pests include inter alia: 
     From the order of the Anoplura (Phthiraptera), for example,  Damalinia  spp.,  Haematopinus  spp.,  Linognathus  spp.,  Pediculus  spp.,  Trichodectes  spp. 
     From the class of the Arachnida, for example,  Acarus siro, Aceria sheldoni, Aculops  spp.,  Aculus  spp.,  Amblyomma  spp.,  Argas  spp.,  Boophilus  spp.,  Brevipalpus  spp.,  Bryobia praetiosa, Chorioptes  spp.,  Dermanyssus gallinae, Eotetranychus  spp.,  Epitrimerus pyri, Eutetranychus  spp.,  Eriophyes  spp.,  Hemitarsonemus  spp.,  Hyalomma  spp.,  Ixodes  spp.,  Latrodectus mactans, Metatetranychus  spp.,  Oligonychus  spp.,  Ornithodoros  spp.,  Panonychus  spp.,  Phyllocoptruta oleivora, Polyphagotarsonemus latus, Psoroptes  spp.,  Rhipicephalus  spp.,  Rhizoglyphus  spp.,  Sarcoptes  spp.,  Scorpio maurus, Stenotarsonemus  spp.,  Tarsonemus  spp.,  Tetranychus  spp.,  Vasates lycopersici.    
     From the class of the Bivalva, for example,  Dreissena  spp. 
     From the order of the Chilopoda, for example, geophilus spp.,  Scutigera  spp. 
     From the order of the Coleoptera, for example, Acanthoscelides obtectus, Adoretus spp.,  Agelastica alni, Agriotes  spp.,  Amphimallon solstitialis, Anobium punctatum, Anoplophora  spp.,  Anthonomus  spp.,  Anthrenus  spp.,  Apogonia  spp.,  Atomaria  spp.,  Attagenus  spp.,  Bruchidius obtectus, Bruchus  spp.,  Ceuthorhynchus  spp.,  Cleonus mendicus, Conoderus  spp.,  Cosmopolites  spp.,  Costelytra zealandica, Curculio  spp.,  Cryptorhynchus lapathi, Dermestes  spp.,  Diabrotica  spp.,  Epilachna  spp.,  Faustinus cubae, gibbium psylloides, Heteronychus arator, Hylamorpha elegans, Hylotrupes bajulus, Hypera postica, Hypothenemus  spp.,  Lachnosterna consanguinea, Leptinotarsa decemlineata, Lissorhoptrus oryzophilus, Lixus  spp.,  Lyctus  spp.,  Meligethes aeneus, Melolontha melolontha, Migdolus  spp.,  Monochamus  spp.,  Naupactus xanthographus, Niptus hololeucus, Oryctes rhinoceros, Oryzaephilus surinamensis, Otiorrhynchus sulcatus, Oxycetonia jucunda, Phaedon cochleariae, Phyllophaga  spp.,  Popillia japonica, Premnotrypes  spp.,  Psylliodes chrysocephala, Ptinus  spp.,  Rhizobius ventralis, Rhizopertha dominica, Sitophilus  spp.,  Sphenophorus  spp.,  Sternechus  spp.,  Symphyletes  spp.,  Tenebrio molitor, Tribolium  spp.,  Trogo -derma spp.,  Tychius  spp.,  Xylotrechus  spp.,  Zabrus  spp. 
     From the order of the Collembola, for example,  Onychiurus armatus.    
     From the order of the  Dermaptera , for example,  Forficula auricularia.    
     From the order of the Diplopoda, for example,  Blaniulus guttulatus.    
     From the order of the Diptera, for example,  Aedes  spp.,  Anopheles  spp.,  Bibio hortulanus, Calliphora erythrocephala, Ceratitis capitata, Chrysomyia  spp.,  Cochliomyia  spp.,  Cordylobia anthropophaga, Culex  spp.,  Cuterebra  spp.,  Dacus oleae, Dermatobia hominis, Drosophila  spp.,  Fannia  spp.,  gastrophilus  spp.,  Hylemyia  spp.,  Hyppobosca  spp.,  Hypoderma  spp.,  Liriomyza  spp.,  Lucilia  spp.,  Musca  spp.,  Nezara  spp.,  Oestrus  spp.,  Oscinella frit, Pegomyia hyoscyami, Phorbia  spp.,  Stomoxys  spp.,  Tabanus  spp.,  Tannia  spp.,  Tipula paludosa, Wohlfahrtia  spp. 
     From the class of the gastropoda, for example,  Arion  spp.,  Biomphalaria  spp.,  Bulinus  spp.,  Deroceras  spp.,  galba  spp.,  Lymnaea  spp.,  Oncomelania  spp.,  Succinea  spp. 
     From the class of the helminths, for example,  Ancylostoma duodenale, Ancylostoma ceylanicum, Acylostoma braziliensis, Ancylostoma  spp.,  Ascaris lubricoides, Ascaris  spp.,  Brugia malayi, Brugia timori, Bunostomum  spp.,  Chabertia  spp.,  Clonorchis  spp.,  Cooperia  spp.,  Dicrocoelium  spp,  Dictyocaulus filaria, Diphyllobothrium latum, Dracunculus medinensis, Echinococcus granulosus, Echinococcus multilocularis, Enterobius vermicularis, Faciola  spp.,  Haemonchus  spp.,  Heterakis  spp.,  Hymenolepis nana, Hyostrongulus  spp.,  Loa Loa, Nematodirus  spp.,  Oesophagostomum  spp.,  Opisthorchis  spp.,  Onchocerca volvulus, Ostertagia  spp.,  Paragonimus  spp.,  Schistosomen  spp.,  Strongyloides fuelleborni, Strongyloides stercoralis, Stronyloides  spp.,  Taenia saginata, Taenia solium, Trichinella spiralis, Trichinella nativa, Trichinella britovi, Trichinella nelsoni, Trichinella pseudopsiralis, Trichostrongulus  spp.,  Trichuris trichuria, Wuchereria bancrofti.    
     It is furthermore possible to control protozoa, such as Eimeria. 
     From the order of the Heteroptera, for example,  Anasa tristis, Antestiopsis  spp.,  Blissus  spp.,  Calocoris  spp.,  Campylomma livida, Cavelerius  spp.,  Cimex  spp.,  Creontiades dilutus, Dasynus piperis, Dichelops furcatus, Diconocoris hewetti, Dysdercus  spp.,  Euschistus  spp.,  Eurygaster  spp.,  Heliopeltis  spp.,  Horcias nobilellus, Leptocorisa  spp.,  Leptoglossus phyllopus, Lygus  spp.,  Macropes excavatus, Miridae, Nezara  spp.,  Oebalus  spp.,  Pentomidae, Piesma quadrata, Piezodorus  spp.,  Psallus seriatus, Pseudacysta persea, Rhodnius  spp.,  Sahlbergella singularis, Scotinophora  spp.,  Stephanitis nashi, Tibraca  spp.,  Triatoma  spp. 
     From the order of the Homoptera, for example, Acyrthosipon spp.,  Aeneolamia  spp.,  Agonoscena  spp.,  Aleurodes  spp.,  Aleurolobus barodensis, Aleurothrixus  spp.,  Amrasca  spp.,  Anuraphis cardui, Aonidiella  spp.,  Aphanostigma piri, Aphis  spp.,  Arboridia apicalis, Aspidiella  spp.,  Aspidiotus  spp.,  Atanus  spp.,  Aulacorthum solani, Bemisia  spp.,  Brachycaudus helichrysii, Brachycolus  spp.,  Brevicoryne brassicae, Calligypona marginata, Carneocephala fulgida, Ceratovacuna lanigera, Cercopidae, Ceroplastes  spp.,  Chaetosiphon fragaefolii, Chionaspis tegalensis, Chlorita onukii, Chromaphis juglandicola, Chrysomphalus ficus, Cicadulina mbila, Coccomytilus halli, Coccus  spp.,  Cryptomyzus ribis, Dalbulus  spp.,  Dialeurodes  spp.,  Diaphorina  spp.,  Diaspis  spp.,  Doralis  spp.,  Drosicha  spp.,  Dysaphis  spp.,  Dysmicoccus  spp.,  Empoasca  spp.,  Eriosoma  spp.,  Erythroneura  spp.,  Euscelis bilobatus, geococcus coffeae, Homalodisca coagulata, Hyalopterus arundinis, Icerya  spp.,  Idiocerus  spp.,  Idioscopus  spp.,  Laodelphax striatellus, Lecanium  spp.,  Lepidosaphes  spp.,  Lipaphis erysimi, Macrosiphum  spp.,  Mahanarva fimbriolata, Melanaphis sacchari, Metcalfiella  spp.,  Metopolophium dirhodum, Monellia costalis, Monelliopsis pecanis, Myzus  spp.,  Nasonovia ribisnigri, Nephotettix  spp.,  Nilaparvata lugens, Oncometopia  spp.,  Orthezia praelonga, Parabemisia myricae, Paratrioza  spp.,  Parlatoria  spp.,  Pemphigus  spp.,  Peregrinus maidis, Phenacoccus  spp.,  Phloeomyzus passerinii, Phorodon humuli, Phylloxera  spp.,  Pinnaspis aspidistrae, Planococcus  spp.,  Protopulvinaria pyriformis, Pseudaulacaspis pentagona, Pseudococcus  spp.,  Psylla  spp.,  Pteromalus  spp.,  Pyrilla  spp.,  Quadraspidiotus  spp.,  Quesada gigas, Rastrococcus  spp.,  Rhopalosiphum  spp.,  Saissetia  spp.,  Scaphoides titanus, Schizaphis graminum, Selenaspidus articulatus, Sogata  spp.,  Sogatella furcifera, Sogatodes  spp.,  Stictocephala festina, Tenalaphara malayensis, Tinocallis caryaefoliae, Tomaspis  spp.,  Toxoptera  spp.,  Trialeurodes vaporariorum, Trioza  spp.,  Typhlocyba  spp.,  Unaspis  spp.,  Viteus vitifolii.    
     From the order of the Hymenoptera, for example, Diprion spp.,  Hoplocampa  spp.,  Lasius  spp.,  Monomorium pharaonis, Vespa  spp. 
     From the order of the Isopoda, for example,  Armadillidium vulgare, Oniscus asellus, Porcellio scaber.    
     From the order of the Isoptera, for example,  Reticulitermes  spp.,  Odontotermes  spp. 
     From the order of the Lepidoptera, for example,  Acronicta major, Aedia leucomelas, Agrotis  spp.,  Alabama argillacea, Anticarsia  spp.,  Barathra brassicae, Bucculatrix thurberiella, Bupalus piniarius, Cacoecia podana, Capua reticulana, Carpocapsa pomonella, Chematobia brumata, Chilo  spp.,  Choristoneura fumiferana, Clysia ambiguella, Cnaphalocerus  spp.,  Earias insulana, Ephestia kuehniella, Euproctis chrysorrhoea, Euxoa  spp.,  Feltia  spp.,  galleria mellonella, Helicoverpa  spp.,  Heliothis  spp.,  Hofmannophila pseudospretella, Homona magnanima, Hyponomeuta padella, Laphygma  spp.,  Lithocolletis blancardella, Lithophane antennata, Loxagrotis albicosta, Lymantria  spp.,  Malacosoma neustria, Mamestra brassicae, Mocis repanda, Mythimna separata, Oria  spp.,  Oulema oryzae, Panolis flammea, Pectinophora gossypiella, Phyllocnistis citrella, Pieris  spp.,  Plutella xylostella, Prodenia  spp.,  Pseudaletia  spp.,  Pseudoplusia includens, Pyrausta nubilalis, Spodoptera  spp.,  Thermesia gemmatalis, Tinea pellionella, Tineola bisselliella, Tortrix viridana, Trichoplusia  spp. 
     From the order of the Orthoptera, for example,  Acheta domesticus, Blatta orientalis, Blattella germanica, gryllotalpa  spp.,  Leucophaea maderae, Locusta  spp.,  Melanoplus  spp.,  Periplaneta americana, Schistocerca gregaria.    
     From the order of the Siphonaptera, for example,  Ceratophyllus  spp.,  Xenopsylla  cheopis. 
     From the order of the Symphyla, for example,  Scutigerella immaculata.    
     From the order of the Thysanoptera, for example,  Baliothrips biformis, Enneothrips flavens, Franldiniella  spp.,  Heliothrips  spp.,  Hercinothrips femoralis, Kakothrips  spp.,  Rhipiphorothrips cruentatus, Scirtothrips  spp.,  Taeniothrips cardamoni, Thrips  spp. 
     From the order of the Thysanura, for example,  Lepisma saccharina.    
     The phytoparasitic nematodes include, for example,  Anguina  spp.,  Aphelenchoides  spp.,  Belonoaimus  spp.,  Bursaphelenchus  spp.,  Ditylenchus dipsaci, globodera  spp.,  Heliocotylenchus  spp.,  Heterodera  spp.,  Longidorus  spp.,  Meloidogyne  spp.,  Pratylenchus  spp.,  Radopholus similis, Rotylenchus  spp.,  Trichodorus  spp.,  Tylenchorhynchus  spp.,  Tylenchulus  spp.,  Tylenchulus semipenetrans, Xiphinema  spp. 
     All plants and plant parts can be treated in accordance with the invention. Plants are to be understood as meaning in the present context all plants and plant populations such as desired and undesired wild plants or crop plants (including naturally occurring crop plants). Crop plants can be plants which can be obtained by conventional plant breeding and optimization methods or by biotechnological and genetic engineering methods or by combinations of these methods, including the transgenic plants and including the plant cultivars protectable or not protectable by plant breeders&#39; rights. Plant parts are to be understood as meaning all parts and organs of plants above and below the ground, such as shoot, leaf, flower and root, examples which may be mentioned being leaves, needles, stalks, stems, flowers, fruit bodies, fruits, seeds, roots, tubers and rhizomes. The plant parts also include harvested material, and vegetative and generative propagation material, for example cuttings, tubers, rhizomes, offshoots and seeds. 
     Treatment according to the invention of the plants and plant parts with the active compounds is carried out directly or by allowing the compounds to act on their surroundings, habitat or storage space by the customary treatment methods, for example by immersion, spraying, evaporation, fogging, scattering, painting on, injecting and, in the case of propagation material, in particular in the case of seed, also by applying one or more coats. 
     As already mentioned above, it is possible to treat all plants and their parts according to the invention. In a preferred embodiment, wild plant species and plant cultivars, or those obtained by conventional biological breeding methods, such as crossing or protoplast fusion, and parts thereof, are treated. In a further preferred embodiment, transgenic plants and plant cultivars obtained by genetic engineering methods, if appropriate in combination with conventional methods (Genetically Modified Organisms), and parts thereof, are treated. The terms “parts”, “parts of plants” and “plant parts” have been explained above. 
     Particularly preferably, plants of the plant cultivars which are in each case commercially available or in use are treated according to the invention. Plant cultivars are understood as meaning plants having novel properties (“traits”) which have been obtained by conventional breeding, by mutagenesis or by recombinant DNA techniques. These can be cultivars, bio- or genotypes. 
     Depending on the plant species or plant cultivars, their location and growth conditions (soils, climate, vegetation period, diet), the treatment according to the invention may also result in superadditive “synergistic”) effects. Thus, for example, reduced application rates and/or a widening of the activity spectrum and/or an increase in the activity of the substances and compositions which can be used according to the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, higher quality and/or a higher nutritional value of the harvested products, better storage stability and/or processability of the harvested products are possible, which exceed the effects which were actually to be expected. 
     The preferred transgenic plants or plant cultivars (obtained by genetic engineering) which are to be treated according to the invention include all plants which, by virtue of the genetic modification, received genetic material which imparts particularly advantageous, useful traits to these plants. Examples of such traits are better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, higher quality and/or a higher nutritional value of the harvested products, better storage stability and/or processability of the harvested products. Further and particularly emphasized examples of such traits are a better defence of the plants against animal and microbial pests, such as against insects, mites, phytopathogenic fungi, bacteria and/or viruses, and also increased tolerance of the plants to certain herbicidally active compounds. Examples of transgenic plants which may be mentioned are the important crop plants, such as cereals (wheat, rice), maize, soya beans, potatoes, sugar beet, tomatoes, peas and other vegetable varieties, cotton, tobacco, oilseed rape and also fruit plants (with the fruits apples, pears, citrus fruits and grapes), and particular emphasis is given to maize, soya beans, potatoes, cotton, tobacco and oilseed rape. Traits that are emphasized in particular are the increased defence of the plants against insects, arachnids, nematodes and slugs and snails by virtue of toxins formed in the plants, in particular those formed in the plants by the genetic material from  Bacillus thuringiensis  (for example by the genes CryIA(a), CryIA(b), CryIA(c), CryIIA, CryIIIA, CryIIIB2, Cry9c, Cry2Ab, Cry3Bb and CryIF and also combinations thereof) (referred to hereinbelow as “Bt plants”). Traits that are also particularly emphasized are the increased defence of the plants against fungi, bacteria and viruses by systemic acquired resistance (SAR), systemin, phytoalexins, elicitors and resistance genes and correspondingly expressed proteins and toxins. Traits that are furthermore particularly emphasized are the increased tolerance of the plants to certain herbicidally active compounds, for example imidazolinones, sulphonylureas, glyphosate or phosphinotricin (for example the “PAT” gene). The genes which impart the desired traits in question can also be present in combination with one another in the transgenic plants. Examples of “Bt plants” which may be mentioned are maize varieties, cotton varieties, soya bean varieties and potato varieties which are sold under the trade names YIELD gARD® (for example maize, cotton, soya beans), KnockOut® (for example maize), StarLink® (for example maize), Bollgard® (cotton), Nucotn® (cotton) and NewLeaf® (potato). Examples of herbicide-tolerant plants which may be mentioned are maize varieties, cotton varieties and soya bean varieties which are sold under the trade names Roundup Ready® (tolerance to glyphosate, for example maize, cotton, soya beans), Liberty Link® (tolerance to phosphinotricin, for example oilseed rape), IMI® (tolerance to imidazolinones) and STS® (tolerance to sulphonylureas, for example maize). Herbicide-resistant plants (plants bred in a conventional manner for herbicide tolerance) which may be mentioned include the varieties sold under the name Clearfield® (for example maize). Of course, these statements also apply to plant cultivars having these genetic traits or genetic traits still to be developed, which plant cultivars will be developed and/or marketed in the future. 
     The plants listed can be treated according to the invention in a particularly advantageous manner with the compounds according to the invention at a suitable concentration. 
     Furthermore, in the field of veterinary medicine, the novel compounds of the present invention can be effectively used against various harmful animal parasitic pests (endoparasites and ectoparasites), for example, insects and helminthes. Examples of such animal parasitic pests include the pests as described below. Examples of the insects include gasterophilus spp.,  Stomoxys  spp.,  Trichodectes  spp.,  Rhodnius  spp.,  Ctenocephalides canis, Cimx lecturius, Ctenocephalides felis, Lucilia cuprina , and the like. Examples of acari include  Ornithodoros  spp.,  Ixodes  spp.,  Boophilus  spp.,  and the like.    
     In the veterinary fields, i.e. in the field of veterinary medicine, the active compounds according to the present invention are active against animal parasites, in particular ectoparasites or endoparasites. 
     The term endoparasites includes in particular helminths, such as cestodes, nematodes or trematodes, and protozoae, such as coccidia. Ectoparasites are typically and preferably arthropods, in particular insects such as flies (stinging and licking), parasitic fly larvae, lice, hair lice, bird lice, fleas and the like; or acarids, such as ticks, for examples hard ticks or soft ticks, or mites, such as scab mites, harvest mites, bird mites and the like. 
     These parasites include: 
     From the order of the Anoplurida, for example  Haematopinus  spp.,  Linognathus  spp.,  Pediculus  spp.,  Phtirus  spp.,  Solenopotes  spp.; particular examples are:  Linognathus setosus, Linognathus vituli, Linognathus ovillus, Linognathus oviformis, Linognathus pedalis, Linognathus stenopsis, Haematopinus asini macrocephalus, Haematopinus eurysternus, Haematopinus suis, Pediculus humanus capitis, Pediculus humanus corporis, Phylloera vastatrix, Phthirus pubis, Solenopotes capillatus;    
     from the order of the Mallophagida and the suborders Amblycerina and Ischnocerina, for example  Trimenopon  spp.,  Menopon  spp.,  Trinoton  spp.,  Bovicola  spp.,  Werneckiella  spp.,  Lepikentron  spp.,  Damalina  spp.,  Trichodectes  spp.,  Felicola  spp.; particular examples are:  Bovicola bovis, Bovicola ovis, Bovicola limbata, Damalina bovis, Trichodectes canis, Felicola subrostratus, Bovicola caprae, Lepikentron ovis, Werneckiella equi;    
     from the order of the Diptera and the suborders Nematocerina and Brachycerina, for example  Aedes  spp.,  Anopheles  spp.,  Culex  spp.,  Simulium  spp.,  Eusimulium  spp.,  Phlebotomus  spp.,  Lutzomyia  spp.,  Culicoides  spp.,  Chrysops  spp.,  Odagmia  spp.,  Wilhelmia  spp.,  Hybomitra  spp.,  Atylotus  spp.,  Tabanus  spp.,  Haematopota  spp.,  Philipomyia  spp.,  Braula  spp.,  Musca  spp.,  Hydrotaea  spp.,  Stomoxys  spp.,  Haematobia  spp.,  Morellia  spp.,  Fannia  spp.,  glossina  spp.,  Calliphora  spp.,  Lucilia  spp.,  Chrysomyia  spp.,  Wohlfahrtia  spp.,  Sarcophaga  spp.,  Oestrus  spp.,  Hypoderma  spp.,  gasterophilus  spp.,  Hippobosca  spp.,  Lipoptena  spp.,  Melophagus  spp.,  Rhinoestrus  spp.,  Tipula  spp.; particular examples are:  Aedes aegypti, Aedes albopictus, Aedes taeniorhynchus, Anopheles gambiae, Anopheles maculipennis, Calliphora erythrocephala, Chrysozona pluvialis, Culex quinquefasciatus, Culex pipiens, Culex tarsalis, Fannia canicularis, Sarcophaga carnaria, Stomoxys calcitrans, Tipula paludosa, Lucilia cuprina, Lucilia sericata, Simulium reptans, Phlebotomus papatasi, Phlebotomus longipalpis, Odagmia ornata, Wilhelmia equina, Boophthora erythrocephala, Tabanus bromius, Tabanus spodopterus, Tabanus atratus, Tabanus sudeticus, Hybomitra ciurea, Chrysops caecutiens, Chrysops relictus, Haematopota pluvialis, Haematopota italica, Musca autumnalis, Musca domestica, Haematobia irritans irritans, Haematobia irritans exigua, Haematobia stimulans, Hydrotaea irritans, Hydrotaea albipuncta, Chrysomya chloropyga, Chrysomya bezziana, Oestrus ovis, Hypoderma bovis, Hypoderma lineatum, Przhevalskiana silenus, Dermatobia hominis, Melophagus ovinus, Lipoptena capreoli, Lipoptena cervi, Hippobosca variegata, Hippobosca equina, gasterophilus intestinalis, gasterophilus haemorroidalis, gasterophilus inermis, gasterophilus nasalis, gasterophilus nigricornis, gasterophilus pecorum, Braula coeca;    
     from the order of the Siphonapterida, for example  Pulex  spp.,  Ctenocephalides  spp.,  Tunga  spp.,  Xenopsylla  spp.,  Ceratophyllus  spp.; particular examples are:  Ctenocephalides canis, Ctenocephalides felis, Pulex irritans, Tunga penetrans, Xenopsylla cheopis;    
     from the order of the Heteropterida, for example  Cimex  spp.,  Triatoma  spp.,  Rhodnius  spp.,  Panstrongylus  spp. 
     From the order of the Blattarida, for example  Blatta orientalis, Periplaneta americana, Blattela germanica, Supella  spp. (e.g.  Suppella longipalpa ); 
     From the subclass of the Acari (Acarina) and the orders of the Meta- and Mesostigmata, for example  Argas  spp.,  Ornithodorus  spp.,  Otobius  spp.,  Ixodes  spp.,  Amblyomma  spp., Rhipicephalus (Boophilus) spp  Dermacentor  spp.,  Haemophysalis  spp.,  Hyalomma  spp.,  Dermanyssus  spp.,  Rhipicephalus  spp. (the original genus of multi host ticks)  Ornithonyssus  spp.,  Pneumonyssus  spp.,  Raillietia  spp.,  Pneumonyssus  spp.,  Sternostoma  spp.,  Varroa  spp.,  Acarapis  spp.; particular examples are:  Argas persicus, Argas reflexus, Ornithodorus moubata, Otobius megnini, Rhipicephalus  ( Boophilus )  microplus, Rhipicephalus  ( Boophilus )  decoloratus, Rhipicephalus  (Boophilus)  annulatus, Rhipicephalus  (Boophilus)  calceratus, Hyalomma anatolicum, Hyalomma aegypticum, Hyalomma marginatum, Hyalomma transiens, Rhipicephalus evertsi, Ixodes ricinus, Ixodes hexagonus, Ixodes canisuga, Ixodes pilosus, Ixodes rubicundus, Ixodes scapularis, Ixodes holocyclus, Haemaphysalis concinna, Haemaphysalis punctata, Haemaphysalis cinnabarina, Haemaphysalis otophila, Haemaphysalis leachi, Haemaphysalis longicorni, Dermacentor marginatus, Dermacentor reticulatus, Dermacentor pictus, Dermacentor albipictus, Dermacentor andersoni, Dermacentor variabilis, Hyalomma mauritanicum, Rhipicephalus sanguineus, Rhipicephalus bursa, Rhipicephalus appendiculatus, Rhipicephalus capensis, Rhipicephalus turanicus, Rhipicephalus zambeziensis, Amblyomma americanum, Amblyomma variegatum, Amblyomma maculatum, Amblyomma hebraeum, Amblyomma cajennense, Dermanyssus gallinae, Ornithonyssus bursa, Ornithonyssus sylviarum, Varroa jacobsoni;    
     from the order of the Actinedida (Prostigmata) and Acaridida (Astigmata), for example  Acarapis  spp.,  Cheyletiella  spp.,  Ornithocheyletia  spp.,  Myobia  spp.,  Psorergates  spp.,  Demodex  spp.,  Trombicula  spp.,  Listrophorus  spp.,  Acarus  spp.,  Tyrophagus  spp.,  Caloglyphus  spp.,  Hypodectes  spp.,  Pterolichus  spp.,  Psoroptes  spp.,  Chorioptes  spp.,  Otodectes  spp.,  Sarcoptes  spp.,  Notoedres  spp.,  Knemidocoptes  spp.,  Cytodites  spp.,  Laminosioptes  spp.; particular examples are:  Cheyletiella yasguri, Cheyletiella blakei, Demodex canis, Demodex bovis, Demodex ovis, Demodex caprae, Demodex equi, Demodex caballi, Demodex suis, Neotrombicula autumnalis, Neotrombicula desaleri, Neoschongastia xerothermobia, Trombicula akamushi, Otodectes cynotis, Notoedres cati, Sarcoptis canis, Sarcoptes bovis, Sarcoptes ovis, Sarcoptes rupicaprae  (= S. caprae ),  Sarcoptes equi, Sarcoptes suis, Psoroptes ovis, Psoroptes cuniculi, Psoroptes equi, Chorioptes bovis, Psoergates ovis, Pneumonyssoidic mange, Pneumonyssoides caninum, Acarapis woodi.    
     The active compounds according to the invention are also suitable for controlling arthropods, helminths and protozoae, which attack animals. Animals include agricultural livestock such as, for example, cattle, sheep, goats, horses, pigs, donkeys, camels, buffaloes, rabbits, chickens, turkeys, ducks, geese, cultured fish, honeybees. Moreover, animals include domestic animals—also referred to as companion animals—such as, for example, dogs, cats, cage birds, aquarium fish and what are known as experimental animals such as, for example, hamsters, guinea pigs, rats and mice. 
     By controlling these arthropods, helminths and/or protozoae, it is intended to reduce deaths and improve performance (in the case of meat, milk, wool, hides, eggs, honey and the like) and health of the host animal, so that more economical and simpler animal keeping is made possible by the use of the active compounds according to the invention. 
     For example, it is desirable to prevent or interrupt the uptake of blood by the parasites from the hosts (when applicable). Also, controlling the parasites may help to prevent the transmittance of infectious agents. 
     The term “controlling” as used herein with regard to the veterinary field, means that the active compounds are effective in reducing the incidence of the respective parasite in an animal infected with such parasites to innocuous levels. More specifically, “controlling”, as used herein, means that the active compound is effective in killing the respective parasite, inhibiting its growth, or inhibiting its proliferation. 
     According to a preferred embodiment the compounds of the present invention are used in the control of ectoparasitic arthropods (as mentioned above) on animals, namely on agricultural livestock or on domestic animals. 
     Generally, when used for the treatment of animals the active compounds according to the invention can be applied directly. Preferably they are applied as pharmaceutical compositions which may contain pharmaceutically acceptable excipients and/or auxiliaries which are known in the art. 
     In the veterinary field and in animal keeping, the active compounds are applied (=administered) in the known manner by enteral administration in the form of, for example, tablets, capsules, drinks, drenches, granules, pastes, boluses, the feed-through method, suppositories; by parenteral administration, such as, for example, by injections (intramuscular, subcutaneous, intravenous, intraperitoneal and the like), implants, by nasal application, by dermal application in the form of, for example, bathing or dipping, spraying, pouring-on and spotting-on, washing, dusting, and with the aid of active-compound-comprising shaped articles such as collars, ear tags, tail tags, limb bands, halters, marking devices and the like. The active compounds may be formulated as shampoo or as suitable formulations usable in aerosols, unpressurized sprays, for example pump sprays and atomizer sprays. 
     When used for livestock, poultry, domestic animals and the like, the active compounds according to the invention can be applied as formulations (for example powders, wettable powders [“WP”], emulsions, emulsifiable concentrates [“EC”], flowables, homogeneous solutions, and suspension concentrates [“SC”]) which comprise the active compounds in an amount of from 1 to 80% by weight, either directly or after dilution (e.g. 100- to 10 000-fold dilution), or else as a chemical bath. 
     When used in the veterinary field the active compounds according to the invention may be used in combination with suitable synergists or other active compounds, such as for example, acaricides, insecticides, anthelmintics, anti-protozoal drugs. 
     In the present invention, a substance having an insecticidal action against pests including all of these is referred to as an insecticide. 
     An active compound of the present invention can be prepared in conventional formulation forms, when used as an insecticide. Examples of the formulation forms include solutions, emulsions, wettable powders, water dispersible granules, suspensions, powders, foams, pastes, tablets, granules, aerosols, active compound-infiltrated natural and synthetic materials, microcapsules, seed coating agents, formulations used with a combustion apparatus (for example, fumigation and smoking cartridges, cans, coils or the like as the combustion apparatus), ULV (cold mist, warm mist), and the like. 
     These formulations can be produced by methods that are known per se. For example, a formulation can be produced by mixing the active compound with a developer, that is, a liquid diluent or carrier; a liquefied gas diluent or carrier; a solid diluent or carrier, and optionally with a surfactant, that is, an emulsifier and/or dispersant and/or foaming agent. 
     In the case where water is used as the developer, for example, an organic solvent can also be used as an auxiliary solvent. 
     Examples of the liquid diluent or carrier include aromatic hydrocarbons (for example, xylene, toluene, alkylnaphthalene and the like), chlorinated aromatic or chlorinated aliphatic hydrocarbons (for example, chlorobenzenes, ethylene chlorides, methylene chlorides), aliphatic hydrocarbons (for example, cyclohexanes), paraffins (for example, mineral oil fractions), alcohols (for example, butanol, glycols and their ethers, esters and the like), ketones (for example, acetone, methyl ethyl ketone, methyl isobutyl ketone, cyclohexanone and the like), strongly polar solvents (for example, dimethylformamide, dimethylsulfoxide and the like), water and the like. 
     The liquefied gas diluent or carrier may be those which are gaseous at normal temperature and normal pressure, for example, aerosol propellants such as butane, propane, nitrogen gas, carbon dioxide and halogenated hydrocarbons. 
     Examples of the solid diluent include pulverized natural minerals (for example, kaolin, clay, talc, chalk, quartz, attapulgite, montmorillonite, diatomaceous earth, and the like), pulverized synthetic minerals (for example, highly dispersed silicic acid, alumina, silicates and the like), and the like. 
     Examples of the solid carrier for granules include pulverized and screened rocks (for example, calcite, marble, pumice, sepiolite, dolomite and the like), synthetic granules of inorganic and organic powder, fine particles of organic materials (for example, sawdust, coconut shells, maize cobs, tobacco stalk and the like), and the like. 
     Examples of the emulsifier and/or foaming agent include nonionic and anionic emulsifiers [for example, polyoxyethylene fatty acid esters, polyoxyethylene fatty acid alcohol ethers (for example, alkylaryl polyglycol ether), alkylsulfonates, alkylsulfates, arylsulfonates and the like], albumin hydrolyzate, and the like. 
     Examples of the dispersant include lignin sulfite waste liquor and methylcellulose. 
     Fixing agents can also be used in the formulations (powders, granules, emulsions), and examples of the fixing agent include carboxymethylcellulose, natural and synthetic polymers (for example, gum arabic, polyvinyl alcohol, polyvinyl acetate, and the like) and the like. 
     Colorants can also be used, and examples of the colorants include inorganic pigments (for example, iron oxide, titanium oxide, Prussian Blue and the like), organic dyes such as alizarin dyes, azo dyes or metal phthalocyanine dyes, and in addition, trace elements such as the salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc. 
     The formulations in general can contain the active ingredient in an amount ranging from 0.1 to 95% by weight, and preferably 0.5 to 90% by weight. 
     The compound according to the present invention can also exist as an admixture with other active compounds, for example, insecticides, poisonous baits, bactericides, miticides, nematicides, fungicides, growth regulators, herbicides and the like, in the form of their commercially useful formulation forms and in the application forms prepared from those formulations. 
     The content of the compound according to the present invention in a commercially useful application form can be varied within a wide range. 
     The concentration of the active compound according to the present invention in actual usage can be, for example, in the range of 0.0000001 to 100% by weight, and preferably 0.00001 to 1% by weight. 
     The compounds according to the present invention can be used through conventional methods that are appropriate for the usage form. 
     The active compound of the present invention have, when used against hygiene pests and pests associated with stored products, stability effective against alkali on lime materials, and also shows excellent residual effectiveness on wood and soil. 
    
    
     Next, the present invention is exemplified by way of the following examples, but the invention is not intended to be limited thereto. References to room temperature means temperatures of about 18 to about 30° C. 
     A: Synthesis of 2-acetyl-5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-isoindol-1-one (Compound No. 1-221) 
     
       
         
         
             
             
         
       
     
     5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-isoindol-1-one (100 mg) was heated and refluxed in anhydrous acetic acid (246 mg) for 2 hours. After removing anhydrous acetic acid by distillation under a reduced pressure, the mixture was diluted with an appropriate amount of t-butyl methyl ether, washed with water and a saturated saline solution, and dried over magnesium sulfate. After separation by filtration, the solvent was distilled off under a reduced pressure and the resulting residue was purified with silica gel chromatography to obtain 2-acetyl-5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-isoindol-1-one (70 mg) in 63% yield. 
       1 H-NMR (CDCl 3 ) δ: 2.70 (3H, s), 3.76 (1H, d, J=17.0 Hz), 4.14 (1H, d, J=17.4 Hz), 4.85 (2H, s), 7.44-7.45 (1H, m), 7.51-7.52 (2H, m), 7.81-7.83 (2H, m), 7.96-7.99 (1H, m). 
     B: Synthesis of 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-benzofuran-1(3H)-one (Compound No. 1-2) 
     Step 1. Synthesis of methyl 2-[(acetyloxy)methyl]-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]benzoate 
     
       
         
         
             
             
         
       
     
     Methyl 2-(bromomethyl)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-oxazol-3-yl]benzoate (887 mg) and sodium acetate (285 mg) were dissolved in DMF (10 ml) and then stirred at 70° C. for 5 hours. After cooled to room temperature, the mixture was diluted with an appropriate amount of t-butyla methyl ether, washed with water three times and with a saturated saline solution, and dried over magnesium sulfate. After separation by filtration, the solvent was distilled off under a reduced pressure to obtain methyl 2-[(acetyloxy)methyl]-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-benzoate (850 mg) in 99% crude yield. 
       1 H-NMR (CDCl 3 ) δ: 2.17 (3H, s), 3.73 (1H, d), 3.93 (3H, s), 4.12 (1H, d), 5.52 (2H, s), 7.43-7.44 (1H, m), 7.52-7.52 (2H, m), 7.63-7.65 (1H, m), 7.83-7.83 (1H, m), 8.02-8.05 (1H, m). 
     Step 2. Synthesis of 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-benzofuran-1(3H)-one (Compound No. 1-2) 
     
       
         
         
             
             
         
       
     
     Methyl 2-[(acetyloxy)methyl]-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]benzoate (851 mg) and sodium methoxide (9 mg) were stirred in methanol (10 ml) at room temperature for 30 min. Under a reduced pressure, the solvent was removed by distillation. Then, the residue was diluted with an appropriate amount of t-butyl methyl ether, washed with water and a saturated saline solution, and dried over magnesium sulfate. After separation by filtration, the solvent was distilled off under a reduced pressure and the resulting residue was purified with silica gel chromatography to obtain 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-benzofuran-1(3H)-one (140 mg) in 19% yield. 
       1 H-NMR (CDCl 3 ) δ: 3.94 (2H, m), 5.36 (2H, s), 7.44-7.51 (3H, m), 7.78-8.04 (3H, m). 
     C: Synthesis of N-[(1E)-5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-ylinden]acetamide (Compound No. 1-235) 
     Step 1. Synthesis of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-methylbenzonitrile 
     
       
         
         
             
             
         
       
     
     3-(4-bromo-3-methylphenyl)-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazole (5.10 g) was dissolved in DMF (10 ml), and under an argon atmosphere zinc cyanide (0.93 g) and tetrakis(triphenylphosphine)palladium (1.30 g) were added thereto. The mixture was then stirred at 80° C. for 4 hours. After cooled to room temperature, the mixture was diluted with an appropriate amount of t-butyl methyl ether, washed with water and dried over magnesium sulfate. After separation by filtration, the solvent was distilled off under a reduced pressure and the resulting crystal was washed with hexane to obtain 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-methylbenzonitrile (3.0 g) in 66% yield. 
       1 H-NMR (CDCl 3 ) δ: 2.59 (3H, s), 3.69 (1H, d), 4.07 (1H, d), 7.43-7.44 (1H, m), 7.50-7.50 (2H, m), 7.56-7.58 (1H, m), 7.63-7.67 (2H, m). 
     Step 2. Synthesis of 2-(bromomethyl)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]benzonitrile 
     
       
         
         
             
             
         
       
     
     A dichloroethane solution (38 ml) of 4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-methylbenzonitrile (1.0 g), N-bromosuccinimide (0.62 g) and a catalytic amount of 2,2′-azobisisobutyronitrile (MEIN) was heated and refluxed for 3 hours. After the solution was cooled to room temperature, insoluble matters were filtered out and the solvent was distilled off under a reduced pressure. The residue was dissolved in t-butyl methyl ether, then washed with water, and dried over magnesium sulfate. After separation by filtration again, the solvent was distilled off under a reduced pressure to obtain 2-(bromomethyl)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]benzonitrile as a crude product. The crude product thus obtained was used for a further reaction without any purification. 
       1 H-NMR (CDCl 3 ) δ: 3.71 (1H, d), 4.09 (1H, d), 4.64 (2H, s), 7.45-7.48 (3H, m), 7.72-7.73 (2H, m), 7.83-7.86 (1H, m). 
     Step 3. Synthesis of 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-imine 
     
       
         
         
             
             
         
       
     
     2-(bromomethyl)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]benzonitrile (500 mg), 2-pyridylmethylamine (113 mg) and potassium carbonate (289 mg) in acetonitrile (10 ml) were heated and refluxed for 3 hours. After cooled to room temperature, the mixture was diluted with an appropriate amount of t-butyl methyl ether, washed with water and a saturated saline solution, and dried over magnesium sulfate. After separation by filtration, the solvent was distilled off under a reduced pressure and the resulting residue was purified with silica gel chromatography to obtain 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-imine (400 mg) in 75% yield. 
     Step 4. Synthesis of N-[(1E)-5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-ylinden]acetamide (Compound No. 1-235) 
     
       
         
         
             
             
         
       
     
     Acetyl chloride (94 mg) and pyridine (119 mg) were added to 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-imine (505 mg) in tetrahydrofuran (5 ml) and the mixture was stirred at room temperature for 1 hour. Then, the resulting mixture was diluted with an appropriate amount of t-butyl methyl ether, washed with water and a saturated saline solution, and dried over magnesium sulfate. After separation by filtration, the solvent was distilled off under a reduced pressure and the resulting residue was purified with silica gel chromatography to obtain N-[(1E)—5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-(pyridin-2-ylmethyl)-2,3-dihydro-1H-isoindol-1-ylinden]acetamide (80 mg) in 15% yield. 
       1 H-NMR (CDCl 3 ) δ: 2.12-2.24 (3H, m), 3.60-3.68 (1H, m), 4.02-4.08 (1H, m), 4.73-4.82 (4H, m), 7.13-7.73 (9H, m), 8.44-8.61 (1H, m). 
     D: Synthesis of 1-{5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-1,3-dihydro-2H-isoindol-2-yl}ethanone (Compound No. 1-151) 
     Step 1. Synthesis of 3-[3,4-bis(bromomethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole 
     
       
         
         
             
             
         
       
     
     A dichloroethane solution (38 ml) of 5-(3,5-dichlorophenyl)-3-(3,4-dimethylphenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole (1.0 g), N-bromosuccinimide (1.1 g) and a catalytic amount of 2,2′-azobisisobutyronitrile (AIBN) was heated and refluxed for 3 hours. After the solution was cooled to room temperature, insoluble matters were filtered out and the solvent was distilled off under a reduced pressure. The residue was dissolved in t-butyl methyl ether, then washed with water, and dried over magnesium sulfate. After separation by filtration again, the solvent was distilled off under a reduced pressure to obtain 3-[3,4-bis(bromomethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazole as a crude product. The crude product thus obtained was used for a further reaction without any purification. 
       1 H-NMR (CDCl 3 ) δ: 3.66-3.71 (1H, m), 4.04-4.11 (1H, m), 4.64 (2H, s), 7.41-7.67 (6H, m). 
     Step 2. Synthesis of 1-{5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-1,3-dihydro-2H-isoindol-2-yl}ethanone (Compound No. 1-151). 
     
       
         
         
             
             
         
       
     
     3-[3,4-bis(bromomethyl)phenyl]-5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazole (1.41 g), acetamide (0.15 g) and sodium hydride (0.10 g) were heated and refluxed in tetrahydrofuran solution (30 ml) for 3 hours. After cooled to room temperature, the mixture was diluted with an appropriate amount of t-butyl methyl ether, washed with water and a saturated saline solution, and dried over magnesium sulfate. After separation by filtration, the solvent was distilled off under a reduced pressure and the resulting residue was purified with silica gel chromatography to obtain 1-{5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-1,3-dihydro-2H-isoindol-2-yl}ethanone (100 mg) in 8.8% yield. 
       1 H-NMR (CDCl 3 ) δ: 2.18 (3H, s), 3.71 (1H, d), 4.10 (1H, d), 4.82-4.85 (4H, m), 7.32-7.39 (1H, m), 7.43-7.43 (1H, m), 7.52-7.65 (4H, m). 
     E: 5-(3,5-dichlorophenyl)-3-(1,3-dihydro-2-benzofuran-5-yl)-5-(trifluoromethyl)-4,5-dihydroisoxazole (Compound No. 1-131) 
     Step 1. Synthesis of 2,5-dimethylbenzyl acetate 
     
       
         
         
             
             
         
       
     
     Acetyl chloride (1.5 g) was added to a tetrahydrofuran solution (30 ml) including 2,5-dimethylbenzyl alcohol and triethylamine (2.4 g) under ice cooling. After stirring at room temperature for 1 hour, the reaction solution was diluted with t-butyl methyl ether. The solution was then washed with water and a saturated saline solution, and the organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off under a reduced pressure to obtain 2,5-dimethylbenzyl acetate (2.8 g). 
       1 H-NMR (CDCl 3 ) δ: 2.09 (3H, s), 2.31 (6H, d), 5.09 (2H, s), 7.08-7.12 (3H, m). 
     Step 2. Synthesis of 5-(bromomethyl)-1,3-dihydro-2-benzofuran 
     
       
         
         
             
             
         
       
     
     A dichloroethane solution (30 ml) of 2,5-dimethylbenzyl acetate (3 g), 2,2′-azobisisobutyronitrile (AIBN)(0.2 g) and N-bromosuccinimide (6.8 g) was stirred at 90° C. for 3 hours. Under a reduced pressure, the reaction solution was concentrated, t-butyl methyl ether was added to the residue, and separation was carried out by filtration. The filtered solution was washed with water and a saturated saline solution, and the organic layer was dried over magnesium sulfate. The solvent was distilled off under a reduced pressure and the resulting residue was purified with silica gel chromatography to obtain 2,5-bis(bromomethyl)benzyl acetate (2.0 g), to which ethanol (10 ml) and water (5 ml) were added followed by the addition of sodium hydroxide (0.5 g). The mixture was stirred at room temperature for 1 hour. The reaction solution was then diluted with t-butyl methyl ether, washed with water and a saturated saline solution, and then the organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off under a reduced pressure and the resulting residue was purified with silica gel chromatography to obtain 5-(bromomethyl)-1,3-dihydro-2-benzofuran (0.65 g). 
       1 H-NMR (CDCl 3 ) δ: 4.52 (2H, s), 5.10 (4H, s), 7.19-7.31 (3H, m). 
     Step 3. Synthesis of 1,3-dihydro-2-benzofuran-5-carbaldehyde 
     
       
         
         
             
             
         
       
     
     A N,N-dimethylformamide solution (10 ml) of 5-(bromomethyl)-1,3-dihydro-2-benzofuran (0.7 g) and sodium acetate (0.54 g) was stirred at 70° C. for 3 hours. The reaction solution was diluted with t-butyl methyl ether, then washed with water and a saturated saline solution, and the organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off under a reduced pressure to obtain 1,3-dihydro-2-benzofuran-5-ylmethyl acetate as a crude product. The crude product thus obtained was dissolved in methanol (10 ml), sodium methoxide (0.05 g) was added thereto and the mixture was stirred for 1 hour at room temperature. The reaction solution was diluted with t-butyl methyl ether, then washed with water and a saturated saline solution, and the organic layer was dried over magnesium sulfate. The solvent was distilled off under a reduced pressure to obtain 1,3-dihydro-2-benzofuran-5-ylmethanol as a crude product. The crude product thus obtained was dissolved in methylene chloride (20 ml), activated manganese (IV) oxide (2.3 g) was added thereto and the mixture was heated and refluxed for 5 hours. The reaction solution was filtered using Celite and the filtered solution was concentrated under a reduced pressure. The resulting residue was purified with silica gel chromatography to obtain 1,3-dihydro-2-benzofuran-5-carbaldehyde (0.35 g). 
       1 H-NMR (CDCl 3 ) δ: 5.16 (4H, s), 7.39-7.41 (1H, m), 7.78-7.80 (2H, m), 10.02 (1H, s). 
     Step 4. Synthesis of 5-(3,5-dichlorophenyl)-3-(1,3-dihydro-2-benzofuran-5-yl)-5-(trifluoromethyl)-4,5-dihydroisoxazole (Compound No. 1-131) 
     
       
         
         
             
             
         
       
     
     Ethanol (10 ml) and water (6 ml) solution including 1,3-dihydro-2-benzofuran-5-carbaldehyde (0.4 g), hydroxyamine hydrochloride (0.28 g) and sodium acetate (0.45 g) was stirred at room temperature for 1 hour. The reaction solution was diluted with t-butyl methyl ether, then washed with water and a saturated saline solution, and then the organic layer was dried over anhydrous magnesium sulfate. The solvent was distilled off under a reduced pressure to obtain 1-(1,3-dihydro-2-benzofuran-5-yl)-N-hydroxymethanimine (0.2 g) as a crude product. The crude product thus obtained was dissolved in N,N-dimethylformamide (10 ml), N-chlorosuccinimide (0.18 g) was added thereto, and the mixture was stirred at room temperature for 2 hours. To the reaction solution, 1,3-dichloro-5-[1-(trifluoromethyl)vinyl]benzene (0.2 g) was added. After cooled to 0° C., potassium hydrogen carbonate (0.1 g) was added thereto and the mixture was stirred at room temperature for 8 hours. After adding water, extraction was carried out using t-butyl methyl ether. The organic layer was washed with a saturated saline solution, and then dried over magnesium sulfate. The solvent was distilled off under a reduced pressure and the resulting residue was purified with silica gel chromatography to obtain 5-(3,5-dichlorophenyl)-3-(1,3-dihydro-2-benzofuran-5-yl)-5-(trifluoromethyl)-4,5-dihydroisoxazole (0.14 g). 
       1 H-NMR (CDCl 3 ) δ: 3.72 (1H, d), 4.11 (1H, d), 5.11 (4H, s), 7.27-7.30 (1H, m), 7.41-7.41 (1H, m), 7.51-7.57 (4H, m). 
     F: Synthesis of 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-benzofuran-1(3H)-imine (Compound No. 1-232) 
     Step 1. Synthesis of 2-cyano-5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]benzyl acetate 
     
       
         
         
             
             
         
       
     
     2-(bromomethyl)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]benzonitrile (900 mg) and sodium acetate (300 mg) were dissolved in N,N-dimethylformamide (10 ml) and the mixture was stirred at 70° C. for 5 hours. After cooled to room temperature, the mixture was diluted with an appropriate amount of t-butyl methyl ether, washed with water three times and with a saturated saline solution, and dried over magnesium sulfate. After separation by filtration, the solvent was distilled off under a reduced pressure and the resulting residue was purified with silica gel chromatography to obtain 2-cyano-5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]benzyl acetate (250 mg) in 30% yield. 
       1 H-NMR (CDCl 3 ) δ: 2.16 (3H, s), 3.72 (1H, d), 4.10 (1H, d), 5.30 (2H, s), 7.44-7.44 (1H, m), 7.48-7.52 (2H, m), 7.72-7.78 (2H, m), 7.81-7.84 (1H, m). 
     Step 2. Synthesis of 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-benzofuran-1(3H)-imine (Compound No. 1-232) 
     
       
         
         
             
             
         
       
     
     2-cyano-5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]benzyl acetate (300 mg) and sodium methoxide (10 mg) in methanol (10 ml) was stirred at room temperature for 30 min. After removing the solvent by distillation under a reduced pressure, the mixture was diluted with an appropriate amount of t-butyl methyl ether, washed with water and a saturated saline solution, and dried over magnesium sulfate. After separation by filtration, the solvent was distilled off under a reduced pressure to obtain 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2-benzofuran-1(3H)-imine (200 mg) in 74% yield. 
       1 H-NMR (CDCl 3 ) δ: 3.74 (1H, d), 4.12 (1H, d), 5.34 (2H, s), 7.44-7.44 (1H, m), 7.49-7.52 (2H, m), 7.71-7.73 (1H, m), 7.76-7.79 (1H, m), 7.92-7.95 (1H, m). 
     G: Synthesis of N-{5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-inden-1-yl}acetamide (No. 3-3) 
     Step 1. Synthesis of methyl (2E)-3-(1-oxo-2,3-dihydro-1H-inden-5-yl)prop-2-enoate 
     
       
         
         
             
             
         
       
     
     5-bromoindanone (10 g), methyl acrylate (8.56 ml), and 1,3-bis(diphenyl-phosphino)propane (1.17 g) were dissolved in triethylamine (100 ml)-acetonitrile (100 ml), and palladium acetic acid (0.53 g) was added thereto under argon atmosphere. The reaction solution was heated at 80° C. for 8 hours. After the cooling, methyl acrylate (4.28 ml) was further added to the mixture. It was again heated at 80° C. for 8 hours, and the solvent was distilled off under reduced pressure. Dilute hydrochloric acid and methylene chloride were added for the extraction. The organic layer was dried over magnesium sulfate and the solvent was removed by distillation. After the purification with silica gel chromatography, the title compound was obtained (5.36 g, 52%). 
       1 H-NMR (CDCl 3 ) δ: 2.73 (t, 2H), 3.17 (t, 2H), 3.83 (s, 3H), 6.55 (d, 1H), 7.50-7.82 (m, 4H). 
     Step 2. Synthesis of 1-oxo-2,3-dihydro-1H-inden-5-carbaldehyde 
     
       
         
         
             
             
         
       
     
     Methyl (2E)-3-(I-oxo-2,3-dihydro-1H-inden-5-yl)prop-2-enoate was dissolved in 1,2-dichloroethane (70 ml)-water (70 ml), and sodium periodate (13.25 g) and ruthenium trichloride hydrates (0.18 g) were added thereto at room temperature. The reaction solution was stirred for 4 hours. Sodium thiosulfate and ethyl acetate were added for the extraction. The organic layer was dried over magnesium sulfate and the solvent was removed by distillation. After the purification with silica gel chromatography, the title compound was obtained (1.92 g, 50%). 
       1 H-NMR (CDCl 3 ) δ: 2.78 (t, 2H), 3.25 (t, 2H), 7.90 (s, 2H), 8.00 (s, 1H), 10.14 (s, 1H). 
     Step 3. Synthesis of 5[(E)-(hydroxyimino)methyl]-2,3-dihydro-1H-inden-1-one 
     
       
         
         
             
             
         
       
     
     1-oxo-2,3-dihydro-1H-inden-5-carbaldehyde (2.00 g) and sodium hydrocarbonate (1.36 g) were suspended in ethanol, and hydroxyamine hydrochloride (0.87 g) was added thereto at 0° C. After stirring for 1 hour, the solvent was removed by distillation. Water and ethyl acetate were added for the extraction. The organic layer was dried over magnesium sulfate and the solvent was removed by distillation. The title compound was obtained as a crude product (1.92 g). 
       1 H-NMR (CDCl 3 ) δ: 2.73 (t, 2H), 3.17 (t, 2H), 7.61 (d, 1H), 7.68 (s, 1H), 7.77 (d, 1H), 8.19 (s, 1H). 
     Step 4. Synthesis of 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-inden-1-one 
     
       
         
         
             
             
         
       
     
     5-[(E)-(hydroxyimino)methyl]-2,3-dihydro-1H-inden-1-one (1.92 g) was dissolved in N,N-dimethylformamide (40 ml), and then N-chlorosuccinimide (1.47 g) was added thereto at 0° C. The reaction solution was stirred for 4 hours. After cooling down the mixture to −10° C., 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene (2.91 g) and potassium hydrocarbonate (1.32 g) were added thereto. The reaction solution was stirred for 4 hours. Water and ethyl acetate were added for the extraction. The organic layer was dried over magnesium sulfate and the solvent was removed by distillation. After the purification with silica gel chromatography, the title compound was obtained (2.85 g, 63%). 
     1H-NMR (CDCl3) δ:  1 H-NMR (CDCl 3 ) δ: 2.75 (t, 2H), 3.19 (t, 2H), 3.74 (d, 1H), 4.12 (d, 1H), 7.44 (s, 1H), 7.51 (s, 2H), 7.67 (d, 1H), 7.77-7.83 (m, 2H). 
     Step 5. Synthesis of 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-inden-1-ol 
     
       
         
         
             
             
         
       
     
     5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2,3-dihydro-1H-inden-1-ol (0.83 g) was dissolved in methanol (10 ml) and sodium borohydride (0.11 g) was added thereto at room temperature. After stirring the reaction solution overnight, the solvent was removed by distillation. Water and ethyl acetate were added for the extraction. The organic layer was dried over magnesium sulfate and the solvent was removed by distillation. The title compound was obtained as a crude product (0.77 g). 
     1H-NMR (CDCl3) δ: 1.90-2.03 (m, 1H), 2.48-2.60 (m, 1H), 2.48-2.60 (m, 1H), 2.77-2.90 (m, 1H), 3.00-3.13 (m, 1H), 3.70 (d, 1H), 4.09 (d, 1H), 5.27 (t, 1H), 7.40-7.59 (m, 6H). 
     Step 6. Synthesis of 2-{5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-inden-1-yl}-1H-isoindol-1,3(2H)-dione 
     
       
         
         
             
             
         
       
     
     5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-inden-1-ol (0.80 g), phthalimide (0.31 g) and triphenylphosphine (0.71 g) were dissolved in tetrahydrofuran (10 ml), and then diethyl azodicarboxylc acid (40%/toluene, 1.32 ml) was added thereto at room temperature. The reaction solution was stirred for 3 hours. The solvent was removed by distillation. After the purification with silica gel chromatography, the title compound was obtained (0.58 g, 55%). 
     1H-NMR (CDCl3) δ: 2.42-2.66 (m, 2H), 2.95-3.09 (m, 1H), 3.31-3.43 (m, 1H), 3.68 (d, 1H), 4.07 (m, 1H), 5.89 (t, 1H), 7.15 (s, 1H), 7.42 (s, 1H), 7.45 (d, 1H), 7.50 (s, 2H), 7.61 (d, 1H), 7.70-7.78 (m, 2H), 7.80-7.90 (m, 2H). 
     Step 7. Synthesis of 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-inden-1-amine 
     
       
         
         
             
             
         
       
     
     2-{5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2,3-dihydro-1H-inden-1-yl}-1H-isoindol-1,3(2H-dione (0.58 g) was dissolved in ethanol (10 ml), and then hydrazine hydrate (0.10 ml) was added thereto. The reaction solution was heated at 80° C. for 5 hours. The solvent was removed by distillation and ethyl acetate was added. Precipitates were removed by filtration, and the filtrate was concentrated. The title compound was obtained as a crude product (0.39 g). 
     1H-NMR (CDCl3) δ: 1.64-1.80 (m, 1H), 2.10 (bs, 2H), 2.47-2.61 (m, 1H), 2.75-2.90 (m, 1H), 2.90-3.05 (m, 1H), 3.69 (d, 1H), 4.08 (d, 1H), 4.38 (t, 1H), 7.35-7.44 (m, 2H), 7.46-7.57 (m, 4H). 
     Step 8. Synthesis of N-{5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-2,3-dihydro-1H-inden-1-yl}acetamide 
     
       
         
         
             
             
         
       
     
     5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2,3-dihydro-1H-inden-1-amine (0.10 g) was dissolved in tetrahydrofuran (2 ml), and then anhydrous acetic acid (0.028 ml) was added thereto at room temperature. After stirring overnight, the solvent was removed by distillation. After the purification with silica gel chromatography, the title compound was obtained (0.086 g, 75%). 
     1H-NMR (CDCl3) δ: 1.74-1.91 (m, 1H), 2.06 (s, 3H), 2.57-2.70 (m, 1H), 2.82-3.07 (m, 2H), 3.69 (d, 1H), 4.07 (d, 1H), 5.52 (q, 1H), 5.60-5.67 (d, 1H), 7.34 (d, 1H), 7.40-7.61 (m, 5H). 
     H: Synthesis of 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-1,2,3,4-tetrahydronaphthalen-1-amine (No. 3-211). 
     Step 1. Synthesis of 5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethane sulfonate 
     
       
         
         
             
             
         
       
     
     6-hydroxy-3,4-dihydro-1(2H)-naphthalenone (10.30 g) and 2,6-lutidine (14.80 ml) were dissolved in methylene chloride (150 ml), and anhydrous trifluoromethane sulfonic acid (25 g) was added thereto at 0° C. The reaction solution was stirred overnight at room temperature. Dilute hydrochloric acid was added for the extraction. The organic layer was dried over magnesium sulfate and the solvent was removed by distillation. After the purification with silica gel chromatography, the title compound was obtained (17.00 g, 91%). 
     1H-NMR (CDCl3) δ: 2.12-2.24 (m, 2H), 2.69 (t, 2H), 3.02 (t, 2H), 7.18-7.23 (m, 2H), 8.14 (d, 1H). 
     Step 2. Synthesis of methyl (2E)-3-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-enoate 
     
       
         
         
             
             
         
       
     
     5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl trifluoromethane sulfonate (7.10 g), methyl acrylate (13.0 ml), 1,3-bis(diphenylphosphino)propane (0.60 g) and triethylamine (10.1 ml) were dissolved in N,N-dimethylformamide (80 ml), and the resulting mixture was stirred under argon atmosphere for 10 min. To the reaction solution, palladium acetic acid (0.27 g) was added and the reaction solution was heated at 80° C. for 10 hours. Water and ethyl acetate were added for the extraction. The organic layer was dried over magnesium sulfate and the solvent was removed by distillation. After the purification with silica gel chromatography, the title compound was obtained (4.10 g, 74%). 
     1H-NMR (CDCl3) δ: 2.09-2.21 (m, 1H), 2.67 (t, 1H), 2.98 (t, 1H), 3.82 (s, 3H), 6.51 (d, 1H), 7.39 (s, 1H), 7.46 (d, 1H), 7.68 (d, 1H), 8.04 (d, 1H). 
     Step 3. Synthesis of 5-oxo-5,6,7,8-tetrahydronaphthalen-2-carbaldehyde 
     
       
         
         
             
             
         
       
     
     Methyl (2E)-3-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)prop-2-enoate was dissolved in 1,2-dichloroethane (70 ml)-water (70 ml), and sodium periodate (13.25 g) and ruthenium trichloride hydrate (0.18 g) were added thereto at room temperature. The reaction solution was stirred for 4 hours. Sodium thiosulfate and ethyl acetate were added for the extraction. The organic layer was dried over magnesium sulfate and the solvent was removed by distillation. After the purification with silica gel chromatography, the title compound was obtained (1.92 g, 50%). 
     1H-NMR (CDCl3) δ: 2.10-2.25 (m, 2H), 2.72 (t, 2H), 3.07 (t, 2H), 7.72-7.83 (m, 2H), 8.18 (d, 1H), 10.08 (s, 1H). 
     Step 4. Synthesis of 6-[(E)-(hydroxyimino)methyl]-3,4-dihydronaphthalen-1(2H)-one 
     
       
         
         
             
             
         
       
     
     1-oxo-2,3-dihydro-1H-inden-5-carbaldehyde (2.46 g) and sodium hydrocarbonate (1.42 g) were suspended in ethanol (70 ml), and hydroxyamine hydrochloride (0.98 g) was added thereto at 0° C. After stirring for 1 hour, the solvent was removed by distillation. Water and ethyl acetate were added for the extraction. The organic layer was dried over magnesium sulfate and the solvent was removed by distillation. The title compound was obtained as a crude product (2.60 g). 
     1H-NMR (CDCl3) δ: 2.10-2.21 (m, 2H), 2.68 (t, 2H), 2.99 (t, 2H), 7.47 (s, 1H), 7.52 (d, 1H), 7.75 (bs, 1H), 8.05 (d, 1H), 8.14 (s, 1H). 
     Step 5. Synthesis of 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-3,4-dihydronaphthalen-1(2H)-one 
     
       
         
         
             
             
         
       
     
     6-[(E)-(hydroxyimino)methyl]-3,4-dihydronaphthalen-1(2H)-one (2.67 g) was dissolved in N,N-dimethylformamide (50 ml), and then N-chlorosuccinimide (1.89 g) was added thereto at 0° C. The reaction solution was stirred for 4 hours. While keeping the temperature of the reaction solution at 0° C., 1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene (3.74 g) and potassium hydrocarbonate (1.70 g) were added thereto. The reaction solution was stirred for 3 hours. Water and ethyl acetate were added for the extraction. The organic layer was dried over magnesium sulfate and the solvent was removed by distillation. After the purification with silica gel chromatography, the title compound was obtained (3.60 g, 60%). 
     1H-NMR (CDCl3) δ: 2.11-2.22 (m, 2H), 2.69 (t, 2H), 3.00 (t, 2H), 3.71 (d, 1H), 4.10 (d, 1H), 7.41-7.59 (m, 5H), 8.08 (d, 1H). 
     Step 6. Synthesis of 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-1,2,3,4-tetrahydronaphthalen-1-amine 
     
       
         
         
             
             
         
       
     
     6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-3,4-dihydronaphthalen-1(2H)-one (1.56 g) and ammonium acetate (4.21 g) were dissolved in methanol (40 ml), and then sodium cyanotrihydro borate (0.69 g) was added thereto at room temperature. The reaction solution was heated at 70° C. for 8 hours. The solvent was removed by distillation, and water and tert-butylmethyl ether were added thereto. The aqueous layer was separated off and the organic layer was extracted with concentrated hydrochloric acid. The acidic aqueous layer was neutralized with sodium carbonate and extracted with tert-butylmethyl ether. The organic layer was dried over magnesium sulfate and the solvent was removed by distillation. The title compound was obtained as a crude product (1.15 g). 
     1H-NMR (CDCl3) δ: 1.47-2.11 (m, 6H), 2.68-2.90 (m, 2H), 3.68 (d, 1H), 3.98 (t, 1H), 4.07 (d, 1H), 7.37 (s, 1H), 7.42 (t, 1H), 7.48 (s, 2H), 7.51 (s, 2H). 
     I: Synthesis of 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-N-ethyl-2,3-dihydro-1H-indol-1-carboxamide (No. 3-638) 
     Step 1. Synthesis of tert-butyl 5-formyl-1H-indol-1-carboxyate 
     
       
         
         
             
             
         
       
     
     Indol-5-carboxyaldehyde (8.00 g) and 4-dimethylaminopyridine (0.67 g) were dissolved in acetonitrile (200 ml), and di-tert-butyl bicarbonate (15.6 g) was added thereto at room temperature. After stirring overnight, the solvent was removed by distillation. After the dilution with ethyl acetate, the mixture was washed with dilute hydrochloric acid and an aqueous solution of sodium carbonate. After drying over magnesium sulfate, the solvent was removed by distillation. The title compound was obtained as a crude product (13.5 g). 
     1H-NMR (CDCl3) δ: 1.69 (s, 9H), 6.69 (d, 1H), 7.69 (d, 1H), 7.86 (d, 1H), 8.10 (s, 1H), 8.29 (d, 1H), 10.07 (s, 1H). 
     Step 2. Synthesis of tert-butyl 5-(hydroxymethyl)-2,3-dihydro-1H-indol-1-carboxyate 
     
       
         
         
             
             
         
       
     
     Tert-butyl 5-formyl-1H-indol-1-carboxyate (13.5 g) and triethylamine (7.67 ml) were dissolved in ethanol (150 ml), and then palladium-activated charcoal (10%, 1.33 g) was added thereto at room temperature. Hydrogen gas was introduced thereto using a balloon and the mixture was stirred for 4 days. The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure. After the purification with silica gel chromatography, the title compound was obtained (2.91 g, 52%, 21%). 
     1H-NMR (CDCl3) δ: 1.52-1.62 (m, 10H), 3.08 (t, 2H), 3.98 (t, 2H), 4.61 (d, 2H), 7.10-7.25 (m, 2H), 7.66-7.92 (m, 1H). 
     Step 3. Synthesis of tert-butyl 5-formyl-2,3-dihydro-1H-indol-1-carboxyate 
     
       
         
         
             
             
         
       
     
     Tert-butyl 5-(hydroxymethyl)-2,3-dihydro-1H-indol-1-carboxyate (2.91 g) was dissolved in methylene chloride (50 ml), and then activated manganese dioxide (10.1 g) was added thereto at room temperature. The mixture was stirred overnight. The solids were removed by filtration, and the filtrate was concentrated under reduced pressure. As a result, the title compound was obtained as a crude product (2.73 g). 
     1H-NMR (CDCl3) δ: 1.58 (s, 9H), 3.15 (t, 2H), 4.05 (t, 2H), 7.62-7.73 (m, 2H), 7.80-8.01 (m, 1H), 9.86 (s, 1H). 
     Step 4. Synthesis of tert-butyl 5-[(E)-(hydroxyimino)methyl]-2,3-dihydro-1H-indol-1-carboxyate 
     
       
         
         
             
             
         
       
     
     Tert-butyl 5-formyl-2,3-dihydro-1H-indol-1-carboxyate (2.73 g) and sodium hydrocarbonate (1.39 g) were suspended in ethanol, and then hydroxyamine hydrochloride salt (0.92 g) was added thereto at room temperature. The reaction solution was stirred overnight and the solvent was removed by distillation. Water and ethyl acetate were added for the extraction. The organic layer was dried over magnesium sulfate and the solvent was removed by distillation. As a result, the title compound was obtained as a crude product (2.50 g). 
     1H-NMR (CDCl3) δ: 1.57 (s, 9H), 3.10 (t, 2H), 4.00 (t, 2H), 7.24-7.48 (m, 2H), 7.62-7.92 (m, 1H), 8.07 (s, 1H). 
     Step 5. Synthesis of tert-butyl 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2,3-dihydro-1H-indol-1-carboxyate 
     
       
         
         
             
             
         
       
     
     Tert-butyl 5-[(E)-(hydroxyimino)methyl]-2,3-dihydro-1H-indol-1-carboxyate (2.50 g) was dissolved in N,N-dimethylformamide (50 ml), and then N-chlorosuccinimide (1.27 g) was added thereto at room temperature. The reaction solution was then stirred for 4 hours. After cooling the solution to 0° C., 1,3-dichloro-5-(3,3,3-trifluoroprop-1-ene-2-yl)benzene (2.53 g) and potassium hydrocarbonate (1.15 g) were added thereto. The reaction solution was stirred overnight at room temperature. Water and ethyl acetate were added for the extraction. The organic layer was dried over magnesium sulfate and the solvent was removed by distillation. As a result, the title compound was obtained as a crude product (4.78 g). 
     1H-NMR (CDCl3) δ: 1.57 (s, 9H), 3.11 (t, 2H), 3.67 (d, 1H), 3.94-4.06 (m, 3H), 7.30-7.59 (m, 6H). 
     Step 6. Synthesis of 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-yl]-2,3-dihydro-1H-indole 
     
       
         
         
             
             
         
       
     
     Tert-butyl 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2,3-dihydro-1H-indol-1-carboxyate (4.78 g), concentrated hydrochloric acid (20 ml) and ethanol (75 ml) were mixed and the resulting mixture was heated at 80° C. for 8 hours. Solvent was removed by distillation, and water and ethyl acetate were added. The resulting mixture was neutralized by adding sodium carbonate, and then extracted. The organic layer was dried over magnesium sulfate and the solvent was removed by distillation. After the purification with silica gel chromatography, the title compound was obtained (3.37 g, 88%). 
     1H-NMR (CDCl3) δ: 1.58 (bs, 1H), 3.05 (t, 2H), 3.57-3.69 (m, 3H), 4.04 (d, 1H), 6.56 (d, 1H), 7.23 (d, 1H), 7.40 (s, 1H), 7.47 (s, 1H), 7.51 (s, 2H). 
     Step 7. Synthesis of 5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-N-ethyl-2,3-dihydro-1H-indol-1-carboxamide 
     
       
         
         
             
             
         
       
     
     5-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-2,3-dihydro-1H-indole (0.12 g) and triethylamine (0.042 ml) were dissolved in tetrahydrofuran (2 ml), and ethyl isocyanate (0.047 ml) was added thereto at room temperature. After stirring the mixture overnight, the solvent was removed by distillation. After the purification with silica gel chromatography, the title compound was obtained (0.104 g, 74%). 
     1H-NMR (CDCl3) δ: 1.22 (t, 3H), 3.20 (t, 2H), 3.39 (quintet, 2H), 3.68 (d, 1H), 3.93 (t, 2H), 4.07 (d, 1H), 4.57-4.66 (m, 1H), 7.31 (d, 1H), 7.41 (s, 1H), 7.51 (s, 2H), 7.58 (s, 1H), 7.98 (d, 1H). 
     J: Synthesis of 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-N-ethyl-3,4-dihydroquinolin-1(2H)-carboxamide (No. 3-638). 
     Step 1. Synthesis of (E)-N-hydroxyl-(quinolin-6-yl)methaneimine 
     
       
         
         
             
             
         
       
     
     Quinolin-6-carbaldehyde (1.01 g) and triethylamine (1.34 ml) were dissolved in ethanol (70 ml), and hydroxyamine hydrochloride (0.54 g) was added thereto at room temperature. After stirring the mixture overnight, the solvent was removed by distillation. Water and ethyl acetate were added thereto for extraction. The organic layer was dried over magnesium sulfate and the solvent was removed by distillation. The title compound was obtained as a crude product (1.00 g). 
     1H-NMR (CDCl3) δ: 1.57 (bs, 1H), 7.41-7.49 (m, 1H), 7.89 (s, 1H), 8.06-8.23 (m, 3H), 8.32 (s, 1H), 8.90-8.97 (m, 1H). 
     Step 2. Synthesis of 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinoline 
     
       
         
         
             
             
         
       
     
     (E)-N-hydroxyl-(quinolin-6-yl)methaneimine (0.98 g) was dissolved in N,N-dimethylformamide (50 ml), and then N-chlorosuccinimide (0.83 g) was added thereto at room temperature. The reaction solution was stirred for 1 hour at 50° C. After cooling the reaction solution to 0° C., 1,3-dichloro-5-(3,3,3-trifluoroprop-1-ene-2-yl)benzene (1.50 g) and potassium hydrocarbonate (0.68 g) were added thereto. The reaction solution was stirred overnight at room temperature. Water and ethyl acetate were added for the extraction. The organic layer was dried over magnesium sulfate and the solvent was removed by distillation. After washing with a small amount of hexane for purification, the title compound was obtained (0.88 g, 38%). 
     1H-NMR (CDCl3) δ: 3.83 (d, 1H), 4.23 (d, 1H), 7.41-7.59 (m, 4H), 7.95 (s, 1H), 8.13-8.22 (m, 3H), 8.95-9.00 (m, 1H). 
     Step 3. Synthesis of 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-1,2,3,4-tetrahydroquinoline 
     
       
         
         
             
             
         
       
     
     6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinoline (0.76 g) and sodium cyanotrihydroborate (0.23 g) were dissolved in methanol (20 ml), and then boron trifluoro diethyl ether complex (0.58 ml) was added thereto. The reaction solution was refluxed for 6 hours under heating. The solvent was removed by distillation. After the purification with silica gel chromatography, the title compound was obtained (0.52 g). 
       1 H-NMR (CDCl3) δ: 1.91-1.93 (2H, m), 2.73-2.75 (2H, m), 3.33-3.35 (2H, m), 3.62 (1H, d), 4.02 (1H), 4.21 (1H, s), 6.41 (1H, d), 7.24-7.25 (2H, m), 7.39 (1H, t), 7.51 (2H, s). 
     Step 4. Synthesis of 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-N-ethyl-3,4-dihydroquinolin-1(2H)-carboxamide 
     
       
         
         
             
             
         
       
     
     To the ethyl acetate solution (5 ml) of 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]-1,2,3,4-tetrahydroquinoline (0.163 g), diisopropylethylamine (82 mg) and bis(trichloromethyl)carbonate (64 mg) were added under ice cooling. The reaction solution was stirred for 90 min under ice cooling. After adding an aqueous solution of 70% ethylamine (0.16 ml) to the reaction solution under ice cooling, the reaction solution was stirred at room temperature for 2 hours. Ethyl acetate and water were added to the reaction solution to separate the organic layer, which was then washed with brine and dried over magnesium sulfate. After the filtration, the solution was concentrated under reduced pressure. Residues were purified by silica gel chromatography using a solvent of n-hexane/ethyl acetate (1:2) to obtain the desired compound of 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]-N-ethyl-3,4-dihydroquinolin-1(2H)-carboxamide (150 mg). 
     1H-NMR (CDCl3) δ: 1.15 (3H, t), 1.89-1.98 (2H, m), 2.76 (2H, t), 3.28-3.38 (2H, m), 3.64-3.75 (3H, m), 4.06 (1H, d), 5.02 (1H, t), 7.44-7.48 (7H, m). 
     K: Synthesis of 1-{5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-yl}-3-ethylurea (No. 3-112) 
     Step 1. Synthesis of 1-oxo-2,3-dihydro-1H-inden-5-carbonitrile 
     
       
         
         
             
             
         
       
     
     Under the argon atmosphere, N,N-dimethylformamide solution (50 ml) of 5-bromo-1-indane (5 g), zinc cyanide (1.9 g), and palladium tetrakistriphenylphosphine (2.7 g) was stirred for 1 hour at 85° C. After cooling, the reaction solution was diluted with tert-butylmethylether and washed twice with water. The organic layer was dried over anhydrous magnesium sulfate and then the solvent was removed by distillation under reduced pressure. Thus obtained crystals were washed with tert-butylmethylether to obtain 1-oxo-2,3-dihydro-1H-inden-5-carbonitrile (3.0 g). 
     1H-NMR (CDCl 3 ) δ: 2.76-2.80 (2H, m), 3.21-3.24 (2H, m), 7.65-7.67 (1H, m), 7.82-7.85 (2H, m). 
     Step 2. Synthesis of 1-oxo-2,3-dihydro-1H-inden-5-carboxylc acid 
     
       
         
         
             
             
         
       
     
     1-oxo-2,3-dihydro-1H-inden-5-carbonitrile (1.0 g) was suspended in a solution of concentrated hydrochloric acid (10 ml) and acetic acid (20 ml), and stirred at 120° C. for 16 hours. After cooling, the reaction solution was concentrated under reduced pressure, tert-butyl methyl ether and water was added and then stirred. The organic layer was dried over anhydrous magnesium sulfate. After removing the solvent by distillation under reduced pressure, 1-oxo-2,3-dihydro-1H-inden-5-carboxylc acid (0.7 g) was obtained. 
     1H-NMR (acetone-d 6 ) δ: 2.69-2.75 (3H, m), 3.23-3.25 (3H, m), 7.74 (1H, d), 8.04 (1H, d), 8.19 (1H, s). 
     Step 3. Synthesis of 1-oxo-N-[(trimethylsilylmethyl]-2,3-dihydro-1Hinden-5-carboxyamide 
     
       
         
         
             
             
         
       
     
     1-oxo-2,3-dihydro-1H-inden-5-carboxylc acid (0.1 g), (trimethylsilyl)methylamine (0.06 g), N,N-dimethylaminopyridine (0.01 g) and N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (0.12 g) were dissolved in methylene chloride (5 ml), and the resulting mixture was stirred for 5 hours at room temperature. After adding water, the reaction solution was stirred and the organic layer was dried over anhydrous magnesium sulfate. After removing the solvent by distillation under reduced pressure, and the resulting residues were purified with silica gel chromatography, 1-oxo-N-[(trimethylsilylmethyl]-2,3-dihydro-1Hinden-5-carboxyamide was obtained (0.11 g). 
       1 H-NMR (CDCl 3 ) δ: 0.15 (9H, s), 2.72-2.76 (2H, m), 2.99 (2H, d, J=5.9 Hz), 3.18-3.20 (2H, m), 6.05 (1H, br s), 7.66 (1H, d), 7.79 (1H, d), 7.87 (1H, s). 
     Step 4. Synthesis of tert-butyl(5-{[(trimethylsilyl)methyl]carbamoyl}-2,3-dihydro-1H-inden-1-yl)carbamate 
     
       
         
         
             
             
         
       
     
     1-oxo-N-[(trimethylsilylmethyl]-2,3-dihydro-1Hinden-5-carboxyamide (1.0 g), ammonium acetate (3.2 g) and sodium cyanoborohydride (0.4 g) were dissolved in methanol (30 ml), refluxed for 6 hours under the argon atmosphere, and stirred further at room temperature for 5 hours. The solvent was removed by distillation under reduced pressure, and tert-butyl methyl ether and water were added to the residues and stirred. The organic layer was dried over anhydrous magnesium sulfate and the solvent was removed by distillation under reduced pressure. The residues were dissolved in toluene (30 ml), di-tert-butyl bicarbonate (1.0 g) was added thereto, and the resulting mixture was heated under stirring for 30 min at 100° C. After cooling, the solvent was removed by distillation and the residues were purified by silica gel chromatography to obtain tert-butyl(5-{[(trimethylsilyl)methyl]carbamoyl}-2,3-dihydro-1H-inden-1-yl)carbamate (0.25 g). 
       1 H-NMR (CDCl 3 ) δ: 0.13 (9H,$), 1.49 (9H, s), 1.78-1.84 (1H, m), 2.56-2.66 (1H, m), 2.85-2.98 (4H, m), 4.74-4.77 (1H, m), 5.18-5.21 (1H, m), 5.93-5.96 (1H, m), 7.35 (1H, d), 7.55-7.58 (2H, m). 
     Step 5. Synthesis of tert-butyl(5-{[(trimethylsilyl)methyl]carbamothioyl}-2,3-dihydro-1H-inden-1-yl)carbamate 
     
       
         
         
             
             
         
       
     
     Tert-butyl(5-{[(trimethylsilyl)methyl]carbamoyl}-2,3-dihydro-1H-inden-1-yl)carbamate (0.25 g) and Lawesson&#39;s reagent (0.2 g) were suspended in toluene (10 ml), and the resulting mixture was refluxed under heating for 1 hour. After cooling down to room temperature, the reaction solution was washed with water and saturated brine. The organic layer was dried over anhydrous magnesium sulfate. After removing the solvent under reduced pressure, and the residues were purified by silica gel chromatography, tert-butyl(5-{[(trimethylsilyl)methyl]carbamothioyl}-2,3-dihydro-1H-inden-1-yl)carbamate was obtained (0.25 g). 
       1 H-NMR (CDCl 3 ) δ: 0.18 (9H, s), 1.46 (9H, s), 1.69-1.77 (1H, m), 2.46-2.56 (1H, m), 2.71-2.97 (2H, m), 3.52 (2H, d), 4.76-4.79 (1H, m), 4.98-5.01 (1H, m), 7.23 (1H, d), 7.45 (1H, d), 7.57 (1H, s), 7.96 (1H, br s). 
     Step 6. Synthesis of methyl 1-[(tert-butoxycarbonyl)amino]-N-[(trimethylsilyl)methyl]-2,3-dihydro-1H-inden-5-carboimide thioate 
     
       
         
         
             
             
         
       
     
     Tetrahydrofuran (10 ml) solution of methyl iodide (0.1 g), potassium tert-butoxide (0.09 g) and tert-butyl(5-{[(trimethylsilyl)methyl]carbamothioyl}-2,3-dihydro-1H-inden-1-yl)carbamate (0.25 g) was stirred for 2 hours at room temperature. The reaction solution was diluted by adding t-butyl methyl ether, and then washed with water and saturated brine. The organic layer was dried over anhydrous magnesium sulfate. After removing the solvent by distillation, residues were simply purified by silica gel chromatography to obtain methyl 1-[(tert-butoxycarbonyl)amino-]-N-[(trimethylsilyl)methyl]-2,3-dihydro-1H-inden-5-carboimide thioate (0.25 g). 
     Step 7. Synthesis of tert-butyl {5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-yl}carbamate 
     
       
         
         
             
             
         
       
     
     Under the argon atmosphere, tetrahydrofuran solution (10 ml) of methyl 1-[(tert-butoxycarbonyl)amino]-N-[(trimethylsilyl)methyl]-2,3-dihydro-1H-inden-5-carboimide thioate (0.25 g) and 1,3-dichloro-5-(3,3,3-trifluoropro-1-pene-2-yl)benzene (0.15 g) was cooled to −5° C., and then 1M tetrahydrofuran solution of tetrabutylammonium fluoride (0.2 ml) was slowly added dropwise thereto. The reaction solution was stirred at room temperature for 20 hours, and then diluted with tert-butyl methyl ether and washed with water and saturated brine. The organic layer was dried over anhydrous magnesium sulfate and the solvent was removed by distillation under reduced pressure. The residues were purified by silica gel chromatography to obtain tert-butyl {5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-yl}carbamate (0.23 g). 
       1 H-NMR (CDCl 3 ) δ: 1.49 (9H, s), 1.78-1.88 (1H, m), 2.59-2.62 (1H, m), 2.80-3.02 (2H, m), 3.44 (1H, d), 3.79 (1H, d), 4.41 (1H, d), 4.83-4.89 (2H, m), 5.19-5.22 (1H, m), 7.26-7.29 (2H, m), 7.36-7.39 (2H, m), 7.66-7.73 (2H, m). 
     Step 8. Synthesis of 5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-amine 
     
       
         
         
             
             
         
       
     
     To the methylenechloride solution (10 ml) of tert-butyl {5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-yl}carbamate (0.23 g), trifluoroacetic acid (0.5 g) was added and then the resulting mixture was stirred at room temperature for 2 hours. Under reduced pressure, the solvent was removed by distillation, and tert-butyl methyl ether and a saturated aqueous solution of sodium hydrocarbonate were added to the residues and stirred. The organic layer was dried over anhydrous magnesium sulfate and the solvent was removed by distillation under reduced pressure to obtain 5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-amine (0.17 g). 
       1 H-NMR (CDCl 3 ) δ: 1.85-1.95 (1H, m), 2.51-2.55 (1H, m), 2.82-3.46 (5H, m), 3.77 (1H, d), 4.36-4.52 (2H, m), 4.80-4.85 (1H, m), 7.24-7.28 (2H, m), 7.36-7.37 (1H, m), 7.45 (1H, d, J=7.9 Hz), 7.69-7.72 (2H, m). 
     Step 9. Synthesis of 1-{5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-yl}-3-ethylurea 
     
       
         
         
             
             
         
       
     
     After stirring the tetrahydrofuran solution (5 ml) of 5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-amine (0.09 g) and ethyl isocyanate (0.02 g) for 16 hours, the solvent was removed by distillation. With the purification based on silica gel chromatography, 1-{5-[3-(3,5-dichlorophenyl)-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl]-2,3-dihydro-1H-inden-1-yl}-3-ethylurea was obtained (0.06 g). 
       1 H-NMR (CDCl 3 ) δ: 1.11 (3H, t), 1.65-1.82 (1H, m), 2.51-2.56 (1H, m), 2.77-2.89 (2H, m), 3.17-3.22 (2H, m), 3.42 (1H, d), 3.77 (1H, d), 4.40 (1H, d), 4.81-4.86 (2H, m), 4.98 (1H, d), 5.25-5.28 (1H, m), 7.27-7.37 (4H, m), 7.62-7.68 (2H, m). 
     L: Synthesis of 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol quinolin-2-carbonitrile (No. 1-255). 
     Step 1. Synthesis of 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinoline 1-oxide 
     
       
         
         
             
             
         
       
     
     6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinoline (0.30 g) was dissolved in methylene chloride (15 ml), and then 3-chloroperbenzoic acid (0.21 g) was added thereto at room temperature. After stirring the mixture for 5 hours, an aqueous solution of sodium thiosulfate was added thereto. The organic layer was separated and washed with an aqueous solution of sodium carbonate. After drying over magnesium sulfate, the title compound was obtained as a crude product (0.24 g). 
     1H-NMR (CDCl3) δ: 3.82 (1H, d), 4.21 (1H, d), 7.37 (1H, dd), 7.44-7.45 (1H, m), 7.53-7.54 (2H, m), 7.74 (1H, d), 8.02-8.02 (1H, m), 8.15 (1H, dd), 8.55 (1H, d), 8.79 (1H, d). 
     Step 2. Synthesis of 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinolin-2-carbonitrile 
     
       
         
         
             
             
         
       
     
     Trimethylsilylcyanide (0.30 g) and triethylamine (0.20 g) were added to acetonitrile (10 ml) solution of 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinoline 1-oxide, and then the reaction solution was refluxed for 6 hours. After adding ethyl acetate and water to the reaction solution, the organic layer was separated and washed with brine. The organic layer was dried over magnesium sulfate. After the filtration, it was concentrated under reduced pressure. The residues were purified by silica gel chromatography using the solvent of n-hexane/ethyl acetate (3:1) to obtain the title compound of 6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinolin-2-carbonitrile (0.30 g). 
       1 H-NMR (CDCl 3 ) δ: 3.84 (1H, d), 4.22 (1H, d), 7.44 (1H, t), 7.54-7.54 (2H, m), 7.77 (1H, d), 8.00 (1H, d), 8.21 (1H, d Hz), 8.29-8.33 (21-I, m). 
     M: Synthesis of 2-chloro-6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinoline (No. 3-777) and 4-chloro-6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinoline 
     
       
         
         
             
             
         
       
     
     6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinoline 1-oxide (0.24 g) was dissolved in phosphorus oxychloride (0.60 ml) at room temperature, and stirred for 9 hours. Ethyl acetate and water were added to the reaction solution for extraction. The organic layer was dried over magnesium sulfate, and the solvent was removed by distillation. With the purification based on silica gel chromatography, 4-chloro-6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinoline was obtained (0.083 g, yield 22%), and also 2-chloro-6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinoline was obtained (0.12 g, yield 30%). 
     1H-NMR (CDCl3) δ: 3.81 (d, 1H), 4.20 (d, 1H), 7.40-7.49 (m, 2H), 7.54 (s, 2H), 7.96 (s, 1H), 8.01-8.22 (m, 3H) of 2-chloro-6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydro-isoxazol-3-yl]quinoline. 
     1H-NMR (CDCl3) δ: 3.86 (d, 1H), 4.25 (d, 1H), 7.45 (s, 1H), 7.53-7.60 (m, 3H) 8.16 (d, 1H), 8.24-8.31 (m, 2H), 8.84 (d, 1H) of 4-chloro-6-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl]quinoline. 
     The compounds of the present invention as well as useful intermediates for the manufacturing of the compounds are described in the following tables. In the tables, abbreviations are as follows. Pr: propyl, Bu: butyl, Ph: phenyl, py: pyridyl, n-: normal, iso-: iso, tert-: tertiary, cyc-: cyclo, dio: dioxolan, pyrim: pyrimidine, pyra: pyrazole, tria: triazole, thia: thiazole. In addition, symbol (−) described in columns for W1 to W4 indicates a single bond, ie. that W is omitted. 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 Example 
                 (X) m   
                 A 
                 (Y) n   
                 W 1   
                 W 2   
                 W 3   
                 W 4   
               
               
                   
               
               
                 1-1 
                 3,5-F2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-2 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-3 
                 3,5-Br2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-4 
                 3,5-I2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-5 
                 3-F 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-6 
                 3-Cl 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-7 
                 3-Br 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-8 
                 3-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-9 
                 4-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-10 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-11 
                 3-NO2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-12 
                 3-CH3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-13 
                 3-CH3O 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-14 
                 3-CN 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-15 
                 3-CF3O 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-16 
                 3-CH3S 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-17 
                 3-CH3S(O) 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-18 
                 3-CH3S(O)2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-19 
                 3-CF3S 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-20 
                 3-CF3S(O) 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-21 
                 3-CF3S(O)2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-22 
                 3-OH 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-23 
                 3-SH 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-24 
                 3-NH2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-25 
                 3-NHCOCH3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-26 
                 3-NHCOCF3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-27 
                 3-NHCO2CH3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-28 
                 3-NHCO2-CH2CCl3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-29 
                 3-NHSO2CH3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-30 
                 3-NHSO2CF3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-31 
                 3-NHCH3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-32 
                 3-N(CH3)2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-33 
                 3-NHCOBu-t 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-34 
                 3-Cl, 4-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-35 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-36 
                 3-Cl, 5-SCF3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-37 
                 3,4,5-F3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-38 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-39 
                 3,4,5-Br3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-40 
                 3,5-Cl2, 4-Br 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-41 
                 3,5-Br2, 4-Cl 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-42 
                 3,5-Cl2, 4-NH2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-43 
                 3,5-Br2, 4-NH2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-44 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-45 
                 3,5-Cl2, 4-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-46 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 S 
                 C═O 
               
               
                 1-47 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 S 
                 C═O 
               
               
                 1-48 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-49 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-50 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NH 
                 C═O 
               
               
                 1-51 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NH 
                 C═O 
               
               
                 1-52 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH3 
                 C═O 
               
               
                 1-53 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NCH3 
                 C═O 
               
               
                 1-54 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NC2H5 
                 C═O 
               
               
                 1-55 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NC2H5 
                 C═O 
               
               
                 1-56 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2CF3 
                 C═O 
               
               
                 1-57 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2CF3 
                 C═O 
               
               
                 1-58 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2-(pyridin-2-yl) 
                 C═O 
               
               
                 1-59 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2-(pyridin-2-yl) 
                 C═O 
               
               
                 1-60 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NC3H7-n 
                 C═O 
               
               
                 1-61 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NC3H7-iso 
                 C═O 
               
               
                 1-62 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NC3H7-cyclo 
                 C═O 
               
               
                 1-63 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NC4H9-n 
                 C═O 
               
               
                 1-64 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NC4H9-iso 
                 C═O 
               
               
                 1-65 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NC4H9-tert 
                 C═O 
               
               
                 1-66 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2—(C3H7-cyclo) 
                 C═O 
               
               
                 1-67 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2CH═CH2 
                 C═O 
               
               
                 1-68 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2CCH 
                 C═O 
               
               
                 1-69 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NC2H4OCH3 
                 C═O 
               
               
                 1-70 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2CH—(OCH3)2 
                 C═O 
               
               
                 1-71 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2-(pyridin-3-yl) 
                 C═O 
               
               
                 1-72 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2-(pyridin-4-yl) 
                 C═O 
               
               
                 1-73 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NC2H4Cl 
                 C═O 
               
               
                 1-74 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2CO2CH3 
                 C═O 
               
               
                 1-75 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2CONH2 
                 C═O 
               
               
                 1-76 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2CONHCH3 
                 C═O 
               
               
                 1-77 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(1,3-dioxolane)-2 
                 C═O 
               
               
                 1-78 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(6-chloro-pyridin-2-yl) 
                 C═O 
               
               
                 1-79 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2Ph 
                 C═O 
               
               
                 1-80 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2-(pyrimidin-2-yl) 
                 C═O 
               
               
                 1-81 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NPh 
                 C═O 
               
               
                 1-82 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NPh-2-Cl 
                 C═O 
               
               
                 1-83 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NPh-3-Cl 
                 C═O 
               
               
                 1-84 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NPh-4-Cl 
                 C═O 
               
               
                 1-85 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NPh-2-CF3 
                 C═O 
               
               
                 1-86 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NPh-3-CF3 
                 C═O 
               
               
                 1-87 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NPh-4-CF3 
                 C═O 
               
               
                 1-88 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NPh-2,4-F2 
                 C═O 
               
               
                 1-89 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N(pyrimidin-2-yl) 
                 C═O 
               
               
                 1-90 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N-(6-chloro-pyrimidin-2-yl) 
                 C═O 
               
               
                 1-91 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N(1H-pyrazol-3) 
                 C═O 
               
               
                 1-92 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N(1H-1,2,4-triazol-3) 
                 C═O 
               
               
                 1-93 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N(1,3-thiazol-2-yl) 
                 C═O 
               
               
                 1-94 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCOH 
                 C═O 
               
               
                 1-95 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCOCH3 
                 C═O 
               
               
                 1-96 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCOC2H5 
                 C═O 
               
               
                 1-97 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCOCF3 
                 C═O 
               
               
                 1-98 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCOPh 
                 C═O 
               
               
                 1-99 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCO2CH3 
                 C═O 
               
               
                 1-100 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCO2C2H5 
                 C═O 
               
               
                 1-101 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCO2C4H9-tert 
                 C═O 
               
               
                 1-102 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCONH2 
                 C═O 
               
               
                 1-103 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCONHPh 
                 C═O 
               
               
                 1-104 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NNH2 
                 C═O 
               
               
                 1-105 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NNHCH3 
                 C═O 
               
               
                 1-106 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NN(CH3)2 
                 C═O 
               
               
                 1-107 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NNCOCH3 
                 C═O 
               
               
                 1-108 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NNCOCF3 
                 C═O 
               
               
                 1-109 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NN═CH(CH3)2 
                 C═O 
               
               
                 1-110 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NOH 
                 C═O 
               
               
                 1-111 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NOCH3 
                 C═O 
               
               
                 1-112 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NOCH2Ph 
                 C═O 
               
               
                 1-113 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NOCOCH3 
                 C═O 
               
               
                 1-114 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═NCH3 
               
               
                 1-115 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═NCH2(py2-yl) 
               
               
                 1-116 
                 3,5-Cl2 
                 O 
                 H 
                 C═O 
                 O 
                 CH2 
                 — 
               
               
                 1-117 
                 3,5-Cl2 
                 O 
                 H 
                 C═O 
                 O 
                 C═O 
                 — 
               
               
                 1-118 
                 3,5-Cl2 
                 O 
                 H 
                 C═O 
                 S 
                 CH2 
                 — 
               
               
                 1-119 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 O 
                 C═O 
               
               
                 1-120 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 C═O 
                 NCH3 
                 C═O 
               
               
                 1-121 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 C═O 
                 NH 
               
               
                 1-122 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CHSCH3 
                 C═O 
                 NH 
               
               
                 1-123 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CHCH3 
                 C═O 
                 NH 
               
               
                 1-124 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 C═O 
                 C═O 
                 NH 
               
               
                 1-125 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 NH 
                 NH 
                 C═O 
               
               
                 1-126 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 NCH3 
                 NH 
                 C═O 
               
               
                 1-127 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 NCH3 
                 NCH3 
                 C═O 
               
               
                 1-128 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 NCH3 
                 NCOCH3 
                 C═O 
               
               
                 1-129 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 NH 
                 C═O 
               
               
                 1-130 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 O 
                 NH 
                 C═O 
               
               
                 1-131 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 O 
                 CH2 
                 — 
               
               
                 1-132 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 O 
                 CH2 
                 — 
               
               
                 1-133 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 S 
                 CH2 
                 — 
               
               
                 1-134 
                 3,5-Cl2 
                 O 
                 H 
                 O 
                 CH2 
                 O 
                 — 
               
               
                 1-135 
                 3,5-Cl2 
                 O 
                 7-Cl 
                 O 
                 CH2 
                 O 
                 — 
               
               
                 1-136 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 O 
               
               
                 1-137 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 O 
               
               
                 1-138 
                 3,5-Cl2 
                 O 
                 H 
                 O 
                 CH 
                 CH 
                 — 
               
               
                 1-139 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 S 
               
               
                 1-140 
                 3,5-Cl2 
                 O 
                 H 
                 S 
                 CH 
                 CH 
                 — 
               
               
                 1-141 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 NH 
               
               
                 1-142 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 NCH3 
               
               
                 1-143 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 NCH2Ph 
               
               
                 1-144 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 NPh 
               
               
                 1-145 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 NCOCH3 
               
               
                 1-146 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 NCOCF3 
               
               
                 1-147 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 NCO2CH3 
               
               
                 1-148 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NH 
                 CH2 
               
               
                 1-149 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2Ph 
                 CH2 
               
               
                 1-150 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 CH2 
               
               
                 1-151 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCOCH3 
                 CH2 
               
               
                 1-152 
                 3,5-Cl2 
                 O 
                 H 
                 NH 
                 CH2 
                 CH2 
                 — 
               
               
                 1-153 
                 3,5-Cl2 
                 O 
                 H 
                 NCH3 
                 CH2 
                 CH2 
                 — 
               
               
                 1-154 
                 3,5-Cl2 
                 O 
                 H 
                 NCO2CH3 
                 CH2 
                 CH2 
                 — 
               
               
                 1-155 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 NH 
               
               
                 1-156 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 NCH3 
               
               
                 1-157 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 NCO2C4H9-tert 
               
               
                 1-158 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 N 
                 NH 
               
               
                 1-159 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 N 
                 NCH3 
               
               
                 1-160 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 N 
                 NPh 
               
               
                 1-161 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 N 
                 NCO2—C4H9-tert 
               
               
                 1-162 
                 3,5-Cl2 
                 O 
                 H 
                 NH 
                 N 
                 CH 
                 — 
               
               
                 1-163 
                 3,5-Cl2 
                 O 
                 H 
                 N 
                 CH 
                 CH 
                 CH 
               
               
                 1-164 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 N 
               
               
                 1-165 
                 3,5-Cl2 
                 O 
                 H 
                 NH 
                 CH2 
                 CH2 
                 CH2 
               
               
                 1-166 
                 3,5-Cl2 
                 O 
                 H 
                 NCH3 
                 CH2 
                 CH2 
                 CH2 
               
               
                 1-167 
                 3,5-Cl2 
                 O 
                 H 
                 NCOCH3 
                 CH2 
                 CH2 
                 CH2 
               
               
                 1-168 
                 3,5-Cl2 
                 O 
                 H 
                 NCOCF3 
                 CH2 
                 CH2 
                 CH2 
               
               
                 1-169 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 NH 
               
               
                 1-170 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 NCH3 
               
               
                 1-171 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 NCOCH3 
               
               
                 1-172 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 NCOCF3 
               
               
                 1-173 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 NCO2CH3 
               
               
                 1-174 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 NCONH2 
               
               
                 1-175 
                 3,5-Cl2 
                 O 
                 H 
                 N 
                 CH 
                 CH 
                 N 
               
               
                 1-176 
                 3,5-Cl2 
                 O 
                 H 
                 NH 
                 CH2 
                 CH2 
                 NH 
               
               
                 1-177 
                 3,5-Cl2 
                 O 
                 H 
                 NCH3 
                 CH2 
                 CH2 
                 NCH3 
               
               
                 1-178 
                 3,5-Cl2 
                 O 
                 H 
                 NCOCH3 
                 CH 
                 CH 
                 NCOCH3 
               
               
                 1-179 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 N 
                 CH 
                 NH 
               
               
                 1-180 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 N 
                 N 
                 NH 
               
               
                 1-181 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NH 
                 CH2 
                 O 
               
               
                 1-182 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 N 
                 CH 
                 O 
               
               
                 1-183 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 N 
                 CCH3 
                 O 
               
               
                 1-184 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NH 
                 C═O 
                 O 
               
               
                 1-185 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NH 
                 C═S 
                 O 
               
               
                 1-186 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NH 
                 S═O 
                 O 
               
               
                 1-187 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NH 
                 S(═O)2 
                 O 
               
               
                 1-188 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 NH 
               
               
                 1-189 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 CH 
                 N 
               
               
                 1-190 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 CCH3 
                 N 
               
               
                 1-191 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 C═O 
                 NH 
               
               
                 1-192 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 C═S 
                 NH 
               
               
                 1-193 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 S═O 
                 NH 
               
               
                 1-194 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 S(═O)2 
                 NH 
               
               
                 1-195 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 O 
                 CH2 
                 NH 
               
               
                 1-196 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 O 
                 CH 
                 N 
               
               
                 1-197 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 O 
                 CCH3 
                 N 
               
               
                 1-198 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 O 
                 C═O 
                 NH 
               
               
                 1-199 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 O 
                 C═S 
                 NH 
               
               
                 1-200 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 O 
                 S═O 
                 NH 
               
               
                 1-201 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 O 
                 S(═O)2 
                 NH 
               
               
                 1-202 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 N 
                 CH 
                 S 
               
               
                 1-203 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 N 
                 CCH3 
                 S 
               
               
                 1-204 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NH 
                 C═O 
                 S 
               
               
                 1-205 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 C═O 
                 S 
               
               
                 1-206 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NH 
                 C═O 
                 NH 
               
               
                 1-207 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 C═O 
                 NCH3 
               
               
                 1-208 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 N 
                 CH 
                 NH 
               
               
                 1-209 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═O 
               
               
                 1-210 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═O 
               
               
                 1-211 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 1-212 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 1-213 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 1-214 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 1-215 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NNH2 
               
               
                 1-216 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NNH2 
               
               
                 1-217 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NNH—CH3 
               
               
                 1-218 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NNH—CH3 
               
               
                 1-219 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NN—(CH3)2 
               
               
                 1-220 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NN—(CH3)2 
               
               
                 1-221 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N—COCH3 
                 C═O 
               
               
                 1-222 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 C═O 
               
               
                 1-223 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 1-224 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 1-225 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 C═NNH2 
               
               
                 1-226 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 C═NNH—CH3 
               
               
                 1-227 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 C═NN—(CH3)2 
               
               
                 1-228 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-229 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-230 
                 3,5-Cl2 
                 NCH3 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-231 
                 3,4,5-Cl3 
                 NCH3 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 1-232 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═NH 
               
               
                 1-233 
                 3,4,5-Cl3 
                 NCH3 
                 H 
                 — 
                 CH2 
                 O 
                 C═NH 
               
               
                 1-234 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═NHCO—CH3 
               
               
                 1-235 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2-(py-2-yl) 
                 C═NHCO—CH3 
               
               
                 1-236 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═CH2 
               
               
                 1-237 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═CH2 
               
               
                 1-238 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 CH—OH 
               
               
                 1-239 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 CH—OH 
               
               
                 1-240 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 NCH2(py-2-yl) 
               
               
                 1-241 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NOCH2(py-2-yl 
               
               
                 1-242 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NNHCOCH3 
               
               
                 1-243 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NNHCH2CF3 
               
               
                 1-244 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 1-245 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═NH 
               
               
                 1-246 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCl 
                 C═O 
               
               
                 1-247 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CCl 
                 CCl 
                 NH 
               
               
                 1-248 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NH 
                 C═O 
                 CH2 
               
               
                 1-249 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 C═O 
                 NN═CH(CH3)2 
                 CH2 
               
               
                 1-250 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 NH 
                 C═O 
               
               
                 1-251 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 C═O 
                 NH 
               
               
                 1-252 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH2—CF3 
               
               
                 1-253 
                 3,5-Cl2 
                 O 
                 H 
                 O 
                 CH2 
                 CH2 
                 O 
               
               
                 1-254 
                 3,4,5-Cl3 
                 O 
                 H 
                 N 
                 CH2 
                 CH2 
                 CH2 
               
               
                 1-255 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CCN 
                 N 
               
               
                 1-256 
                 3,5-Cl2 
                 O 
                 H 
                 CCl 
                 CH 
                 CH 
                 N 
               
               
                 1-257 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 N—O 
               
               
                 1-258 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 NCH2-(py-2-yl) 
               
               
                 1-259 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 NCOCH3 
                 C═O 
               
               
                 1-260 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 1-261 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 C═O 
                 NCH2(py-2-yl) 
                 CH2 
               
               
                 1-262 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 CH2 
               
               
                 1-263 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 C═NCOCH3 
                 NCH3 
                 CH2 
               
               
                 1-264 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═NCO—CH3 
               
               
                 1-265 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 C═O 
                 NCH3 
                 CH2 
               
               
                 1-266 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 C═NCH3 
                 O 
                 CH2 
               
               
                 1-267 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 C═NH 
                 NCH2(py-2-yl) 
                 CH2 
               
               
                 1-268 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2CF3 
                 C═O 
               
               
                 1-269 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N(Ph-4-CF3) 
                 C═O 
               
               
                 1-270 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N(Ph-3-CF3) 
                 C═O 
               
               
                 1-271 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2CH2F 
                 C═O 
               
               
                 1-272 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2CF2CF3 
                 C═O 
               
               
                 1-273 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 N 
                 NH 
                 C═O 
               
               
                 1-274 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 N 
                 NCOCH3 
                 C═O 
               
               
                 1-275 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 N 
                 NCOC2H5 
                 C═O 
               
               
                 1-276 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 N 
                 NCOCH2CF3 
                 C═O 
               
               
                 1-277 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 N 
                 NCOPr-c 
                 C═O 
               
               
                 1-278 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 N 
                 NCOCF3 
                 C═O 
               
               
                 1-279 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 NH 
                 NH 
                 C═O 
               
               
                 1-280 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 NCH3 
                 NH 
                 C═O 
               
               
                 1-281 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 NCH3 
                 NCH3 
                 C═O 
               
               
                 1-282 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 NCH3 
                 NCOCH3 
                 C═O 
               
               
                 1-283 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH 
                 N 
                 NH 
                 C═O 
               
               
                 1-284 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH 
                 N 
                 NCOCH3 
                 C═O 
               
               
                 1-285 
                 3,5-Br2 
                 O 
                 H 
                 CH2 
                 NH 
                 NH 
                 C═O 
               
               
                 1-286 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 CH2 
                 NCH3 
                 NH 
                 C═O 
               
               
                 1-287 
                 3-CF3 
                 O 
                 H 
                 CH2 
                 NCH3 
                 NCH3 
                 C═O 
               
               
                 1-288 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 O 
                 NH 
                 C═O 
               
               
                 1-289 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 O 
                 NCOCH3 
                 C═O 
               
               
                 1-290 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 NCO2-C4H9-t 
                 O 
                 C═O 
               
               
                 1-291 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH2 
                 N 
                 O 
                 C═O 
               
               
                 1-292 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 N 
                 O 
                 C═O 
               
               
                 1-293 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 CH 
                 CBr 
                 N 
               
               
                 1-294 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 CH 
                 CCN 
                 N 
               
               
                 1-295 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CCl 
                 N 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 Example 
                 (X) m -Q 
                 A 
                 (Y) n   
                 W 1   
                 W 2   
                 W 3   
                 W 4   
               
               
                   
               
               
                 2-1 
                 Q-2  
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-2 
                 Q-3  
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-3 
                 Q-4  
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-4 
                 Q-5  
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-5 
                 Q-6  
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-6 
                 Q-7  
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-7 
                 Q-8  
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-8 
                 Q-9  
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-9 
                 Q-10 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-10 
                 Q-11 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-11 
                 Q-12 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-12 
                 Q-13 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-13 
                 Q-14 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-14 
                 Q-15 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-15 
                 Q-16 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-16 
                 Q-17 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-17 
                 Q-18 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-18 
                 Q-19 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-19 
                 Q-20 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-20 
                 Q-21 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-21 
                 Q-22 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-22 
                 Q-23 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-23 
                 Q-24 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-24 
                 Q-25 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-25 
                 Q-26 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-26 
                 Q-27 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-27 
                 Q-28 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-28 
                 Q-29 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-29 
                 Q-30 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-30 
                 Q-31 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-31 
                 Q-32 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-32 
                 Q-33 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-33 
                 Q-34 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-34 
                 Q-35 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-35 
                 Q-36 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-36 
                 Q-37 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-37 
                 Q-38 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-38 
                 Q-39 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-39 
                 Q-40 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-40 
                 Q-41 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-41 
                 Q-42 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-42 
                 2-Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-43 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-44 
                 2-CF3-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-45 
                 2-C2F5-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-46 
                 Q-44 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-47 
                 2-Cl-(Q-44)-5-yl 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-48 
                 Q-43 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-49 
                 2-Cl-(Q-43)-6-yl 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-50 
                 Q-45 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-51 
                 3-Cl-(Q-45)-6-yl 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-52 
                 Q-47 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-53 
                 2-Cl-(Q-47)-5-yl 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-54 
                 Q-46 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-55 
                 4,6-2Cl-(Q-46)-2-yl 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-56 
                 Q-48 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-57 
                 Q-49 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-58 
                 Q-50 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-59 
                 Q-51 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-60 
                 Q-52 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-61 
                 Q-53 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-62 
                 Q-54 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 2-63 
                 Q-2  
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-64 
                 Q-3  
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-65 
                 Q-4  
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-66 
                 Q-5  
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-67 
                 Q-6  
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-68 
                 Q-7  
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-69 
                 Q-8  
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-70 
                 Q-9  
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-71 
                 Q-10 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-72 
                 Q-11 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-73 
                 Q-12 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-74 
                 Q-13 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-75 
                 Q-14 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-76 
                 Q-15 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-77 
                 Q-16 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-78 
                 Q-17 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-79 
                 Q-18 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-80 
                 Q-19 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-81 
                 Q-20 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-82 
                 Q-21 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-83 
                 Q-22 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-84 
                 Q-23 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-85 
                 Q-24 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-86 
                 Q-25 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-87 
                 Q-26 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-88 
                 Q-27 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-89 
                 Q-28 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-90 
                 Q-29 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-91 
                 Q-30 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-92 
                 Q-31 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-93 
                 Q-32 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-94 
                 Q-33 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-95 
                 Q-34 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-96 
                 Q-35 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-97 
                 Q-36 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-98 
                 Q-37 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-99 
                 Q-38 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-100 
                 Q-39 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-101 
                 Q-40 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-102 
                 Q-41 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-103 
                 Q-42 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-104 
                 2-Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-105 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-106 
                 2-CF3-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-107 
                 2-C2F5-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-108 
                 Q-44 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-109 
                 2-Cl-(Q-44)-5-yl 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-110 
                 Q-43 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-111 
                 2-Cl-(Q-43)-6-yl 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-112 
                 Q-45 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-113 
                 3-Cl-(Q-45)-6-yl 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-114 
                 Q-47 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-115 
                 2-Cl-(Q-47)-5-yl 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-116 
                 Q-46 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-117 
                 4,6-2Cl-(Q-46)-2-yl 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-118 
                 Q-48 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-119 
                 Q-49 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-120 
                 Q-50 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-121 
                 Q-51 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-122 
                 Q-52 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-123 
                 Q-53 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-124 
                 Q-54 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═O 
               
               
                 2-125 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 2-126 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 2-127 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 2-128 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 2-129 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 2-130 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-i 
               
               
                 2-131 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 2-132 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2SMe 
               
               
                 2-133 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)Me 
               
               
                 2-134 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 2-135 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CF3 
               
               
                 2-136 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 2-137 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 2-138 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 2-139 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)C2H5 
               
               
                 2-140 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 2-141 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)OCH3 
               
               
                 2-142 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)OC4H9-tert 
               
               
                 2-143 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 2-144 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 2-145 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 2-146 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 2-147 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 2-148 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-i 
               
               
                 2-149 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 2-150 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2SMe 
               
               
                 2-151 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)Me 
               
               
                 2-152 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 2-153 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CF3 
               
               
                 2-154 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 2-155 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 2-156 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 2-157 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)C2H5 
               
               
                 2-158 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 2-159 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)OCH3 
               
               
                 2-160 
                 2,6-2Cl-(Q-42)-4-yl 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)OC4H9-tert 
               
               
                 2-161 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 2-162 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 2-163 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 2-164 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 2-165 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 2-166 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 2-167 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 2-168 
                 2,6-2Cl-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)OC4H9-tert 
               
               
                 2-169 
                 2-CF3-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 2-170 
                 2-CF3-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 2-171 
                 2-CF3-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 2-172 
                 2-CF3-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 2-173 
                 2-CF3-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 2-174 
                 2-CF3-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 2-175 
                 2-CF3-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 2-176 
                 2-CF3-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)OC4H9-tert 
               
               
                 2-177 
                 2-C2F5-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 2-178 
                 2-C2F5-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 2-179 
                 2-C2F5-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 2-180 
                 2-C2F5-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 2-181 
                 2-C2F5-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 2-182 
                 2-C2F5-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 2-183 
                 2-C2F5-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 2-184 
                 2-C2F5-(Q-42)-4-yl 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)OC4H9-tert 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 Example 
                 (X) m   
                 A 
                 (Y) n   
                 W 1   
                 W 2   
                 W 3   
                 W 4   
               
               
                   
               
               
                 3-1 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 3-2 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)H 
               
               
                 3-3 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-4 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-5 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CF3 
               
               
                 3-6 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-7 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-8 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-9 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-10 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-n 
               
               
                 3-11 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-i 
               
               
                 3-12 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-c 
               
               
                 3-13 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-n 
               
               
                 3-14 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-i 
               
               
                 3-15 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-s 
               
               
                 3-16 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-t 
               
               
                 3-17 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-c 
               
               
                 3-18 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H4Cl 
               
               
                 3-19 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CF3 
               
               
                 3-20 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CHCH2 
               
               
                 3-21 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-22 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)CH3 
               
               
                 3-23 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-24 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHC2H5 
               
               
                 3-25 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)N(CH3)2 
               
               
                 3-26 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 3-27 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
               
               
                 3-28 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHSO2CH3 
               
               
                 3-29 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHN(CH3)(C═O)CH3 
               
               
                 3-30 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHN(2-Py)(C═O)NHCH3 
               
               
                 3-31 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHN(CH3)(C═O)NHCH3 
               
               
                 3-32 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H4OH 
               
               
                 3-33 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CH(2-phthalimide) 
               
               
                 3-34 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHOH 
               
               
                 3-35 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHO(C═O)CH3 
               
               
                 3-36 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHO(C═O)NHC2H5 
               
               
                 3-37 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 3-38 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)H 
               
               
                 3-39 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-40 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-41 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CF3 
               
               
                 3-42 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-43 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-44 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-45 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-46 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-n 
               
               
                 3-47 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-i 
               
               
                 3-48 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-c 
               
               
                 3-49 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-n 
               
               
                 3-50 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-i 
               
               
                 3-51 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-s 
               
               
                 3-52 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-t 
               
               
                 3-53 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-c 
               
               
                 3-54 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H4Cl 
               
               
                 3-55 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CF3 
               
               
                 3-56 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CHCH2 
               
               
                 3-57 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-58 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)CH3 
               
               
                 3-59 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-60 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHC2H5 
               
               
                 3-61 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)N(CH3)2 
               
               
                 3-62 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 3-63 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
               
               
                 3-64 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHSO2CH3 
               
               
                 3-65 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHN(CH3)(C═O)CH3 
               
               
                 3-66 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHN(2-Py)(C═O)NHCH3 
               
               
                 3-67 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHN(CH3)(C═O)NHCH3 
               
               
                 3-68 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CH(2-phthalimide) 
               
               
                 3-69 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHOH 
               
               
                 3-70 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHO(C═O)CH3 
               
               
                 3-71 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHO(C═O)NHC2H5 
               
               
                 3-72 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-73 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-74 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-75 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-76 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-77 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-78 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-79 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-80 
                 3,5-Br2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-81 
                 3,5-Br2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-82 
                 3,5-Br2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-83 
                 3,5-Br2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-84 
                 3,5-Br2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-85 
                 3,5-Br2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-86 
                 3,5-Br2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-87 
                 3,5-Br2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-88 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-89 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-90 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-91 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-92 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-93 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-94 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-95 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-96 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-97 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-98 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-99 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-100 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-101 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-102 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-103 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-104 
                 3,5-Cl2  
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 3-105 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)H 
               
               
                 3-106 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-107 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-108 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CF3 
               
               
                 3-109 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-110 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-111 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-112 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-113 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-n 
               
               
                 3-114 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-i 
               
               
                 3-115 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-c 
               
               
                 3-116 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-n 
               
               
                 3-117 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-i 
               
               
                 3-118 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-s 
               
               
                 3-119 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-t 
               
               
                 3-120 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-c 
               
               
                 3-121 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H4Cl 
               
               
                 3-122 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CF3 
               
               
                 3-123 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CHCH2 
               
               
                 3-124 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-125 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)CH3 
               
               
                 3-126 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-127 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHC2H5 
               
               
                 3-128 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)N(CH3)2 
               
               
                 3-129 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 3-130 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
               
               
                 3-131 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHSO2CH3 
               
               
                 3-132 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHN(CH3)(C═O)CH3 
               
               
                 3-133 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHN(2-Py)(C═O)NHCH3 
               
               
                 3-134 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHN(CH3)(C═O)NHCH3 
               
               
                 3-135 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H4OH 
               
               
                 3-136 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CH(2-phthalimide) 
               
               
                 3-137 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHOH 
               
               
                 3-138 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHO(C═O)CH3 
               
               
                 3-139 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHO(C═O)NHC2H5 
               
               
                 3-140 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 3-141 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)H 
               
               
                 3-142 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-143 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-144 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CF3 
               
               
                 3-145 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-146 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-147 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-148 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-149 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-n 
               
               
                 3-150 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-i 
               
               
                 3-151 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-c 
               
               
                 3-152 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-n 
               
               
                 3-153 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-i 
               
               
                 3-154 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-s 
               
               
                 3-155 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-t 
               
               
                 3-156 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-c 
               
               
                 3-157 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H4Cl 
               
               
                 3-158 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CF3 
               
               
                 3-159 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CHCH2 
               
               
                 3-160 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-161 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)CH3 
               
               
                 3-162 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-163 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHC2H5 
               
               
                 3-164 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)N(CH3)2 
               
               
                 3-165 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 3-166 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
               
               
                 3-167 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHSO2CH3 
               
               
                 3-168 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHN(CH3)(C═O)CH3 
               
               
                 3-169 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHN(2-Py)(C═O)NHCH3 
               
               
                 3-170 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHN(CH3)(C═O)NHCH3 
               
               
                 3-171 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CH(2-phthalimide) 
               
               
                 3-172 
                 3,4-Cl2, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-173 
                 3,4-Cl2, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-174 
                 3,4-Cl2, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-175 
                 3,4-Cl2, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-176 
                 3,4-Cl2, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-177 
                 3,4-Cl2, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-178 
                 3,4-Cl2, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-179 
                 3,4-Cl2, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-180 
                 3,5-Br2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-181 
                 3,5-Br2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-182 
                 3,5-Br2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-183 
                 3,5-Br2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-184 
                 3,5-Br2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-185 
                 3,5-Br2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-186 
                 3,5-Br2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-187 
                 3,5-Br2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-188 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-189 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-190 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-191 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-192 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-193 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-194 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-195 
                 3-Cl, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-196 
                 3-Cl, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-197 
                 3-Cl, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-198 
                 3-Cl, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-199 
                 3-Cl, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-200 
                 3-Cl, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-201 
                 3-Cl, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-202 
                 3-Cl, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-203 
                 3,5-Cl2 
                 NCH3 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-204 
                 3,5-Cl2 
                 NCH3 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-205 
                 3,5-Cl2 
                 NCH3 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-206 
                 3,5-Cl2 
                 NCH3 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-207 
                 3,5-Cl2 
                 NCH3 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-208 
                 3,5-Cl2 
                 NCH3 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-209 
                 3,5-Cl2 
                 NCH3 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-210 
                 3,5-Cl2 
                 NCH3 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-211 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 3-212 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)H 
               
               
                 3-213 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-214 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-215 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CF3 
               
               
                 3-216 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2Cl 
               
               
                 3-217 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-218 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-219 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Ph 
               
               
                 3-220 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-221 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-222 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-n 
               
               
                 3-223 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-i 
               
               
                 3-224 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-c 
               
               
                 3-225 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-n 
               
               
                 3-226 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-i 
               
               
                 3-227 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-s 
               
               
                 3-228 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-t 
               
               
                 3-229 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-c 
               
               
                 3-230 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H4Cl 
               
               
                 3-231 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CF3 
               
               
                 3-232 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CHCH2 
               
               
                 3-233 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-234 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)CH3 
               
               
                 3-235 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHPr-c 
               
               
                 3-236 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-237 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHC2H5 
               
               
                 3-238 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)N(CH3)2 
               
               
                 3-239 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 3-240 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
               
               
                 3-241 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNHSO2CH3 
               
               
                 3-242 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHN(CH3)(C═O)CH3 
               
               
                 3-243 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHN(2-Py)(C═O)NHCH3 
               
               
                 3-244 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHN(CH3)(C═O)NHCH3 
               
               
                 3-245 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H4OH 
               
               
                 3-246 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(2-oxazolyl) 
               
               
                 3-247 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CH(2-phthalimide) 
               
               
                 3-248 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHOH 
               
               
                 3-249 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHO(C═O)CH3 
               
               
                 3-250 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHO(C═O)NHC2H5 
               
               
                 3-251 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 3-252 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)H 
               
               
                 3-253 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-254 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-255 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CF3 
               
               
                 3-256 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-257 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-258 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-259 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-260 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-n 
               
               
                 3-261 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-i 
               
               
                 3-262 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-c 
               
               
                 3-263 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-n 
               
               
                 3-264 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-i 
               
               
                 3-265 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-s 
               
               
                 3-266 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-t 
               
               
                 3-267 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-c 
               
               
                 3-268 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H4Cl 
               
               
                 3-269 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CF3 
               
               
                 3-270 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CHCH2 
               
               
                 3-271 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-272 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)CH3 
               
               
                 3-273 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-274 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHC2H5 
               
               
                 3-275 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)N(CH3)2 
               
               
                 3-276 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 3-277 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
               
               
                 3-278 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNHSO2CH3 
               
               
                 3-279 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHN(CH3)(C═O)CH3 
               
               
                 3-280 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHN(2-Py)(C═O)NHCH3 
               
               
                 3-281 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHN(CH3)(C═O)NHCH3 
               
               
                 3-282 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CH(2-phthalimide) 
               
               
                 3-283 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHOH 
               
               
                 3-284 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHO(C═O)CH3 
               
               
                 3-285 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHO(C═O)NHC2H5 
               
               
                 3-286 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-287 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-288 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-289 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-290 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-291 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-292 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-293 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-294 
                 3,5-Br2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-295 
                 3,5-Br2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-296 
                 3,5-Br2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-297 
                 3,5-Br2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-298 
                 3,5-Br2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-299 
                 3,5-Br2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-300 
                 3,5-Br2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-301 
                 3,5-Br2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-302 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-303 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-304 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-305 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-306 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-307 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-308 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-309 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-310 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-311 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-312 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-313 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-314 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-315 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-316 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-317 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-318 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 3-319 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)H 
               
               
                 3-320 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-321 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-322 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CF3 
               
               
                 3-323 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-324 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-325 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-326 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-327 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-n 
               
               
                 3-328 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-i 
               
               
                 3-329 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-c 
               
               
                 3-330 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-n 
               
               
                 3-331 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-i 
               
               
                 3-332 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-s 
               
               
                 3-333 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-t 
               
               
                 3-334 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-c 
               
               
                 3-335 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H4Cl 
               
               
                 3-336 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CF3 
               
               
                 3-337 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CHCH2 
               
               
                 3-338 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-339 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)CH3 
               
               
                 3-340 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-341 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHC2H5 
               
               
                 3-342 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)N(CH3)2 
               
               
                 3-343 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 3-344 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
               
               
                 3-345 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNHSO2CH3 
               
               
                 3-346 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHN(CH3)(C═O)CH3 
               
               
                 3-347 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHN(2-Py)(C═O)NHCH3 
               
               
                 3-348 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHN(CH3)(C═O)NHCH3 
               
               
                 3-349 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CH(2-phthalimide) 
               
               
                 3-350 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHOH 
               
               
                 3-351 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHO(C═O)CH3 
               
               
                 3-352 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHO(C═O)NHC2H5 
               
               
                 3-353 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 3-354 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)H 
               
               
                 3-355 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-356 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-357 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CF3 
               
               
                 3-358 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-359 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-360 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-361 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-362 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-n 
               
               
                 3-363 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-i 
               
               
                 3-364 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-c 
               
               
                 3-365 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-n 
               
               
                 3-366 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-i 
               
               
                 3-367 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-s 
               
               
                 3-368 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-t 
               
               
                 3-369 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHBu-c 
               
               
                 3-370 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H4Cl 
               
               
                 3-371 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CF3 
               
               
                 3-372 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CHCH2 
               
               
                 3-373 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-374 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)CH3 
               
               
                 3-375 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-376 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHC2H5 
               
               
                 3-377 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)N(CH3)2 
               
               
                 3-378 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 3-379 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
               
               
                 3-380 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNHSO2CH3 
               
               
                 3-381 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHN(CH3)(C═O)CH3 
               
               
                 3-382 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHN(2-Py)(C═O)NHCH3 
               
               
                 3-383 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHN(CH3)(C═O)NHCH3 
               
               
                 3-384 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CH(2-phthalimide) 
               
               
                 3-385 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHOH 
               
               
                 3-386 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHO(C═O)CH3 
               
               
                 3-387 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHO(C═O)NHC2H5 
               
               
                 3-388 
                 3,4-Cl2, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-389 
                 3,4-Cl2, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-390 
                 3,4-Cl2, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-391 
                 3,4-Cl2, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-392 
                 3,4-Cl2, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-393 
                 3,4-Cl2, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-394 
                 3,4-Cl2, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-395 
                 3,4-Cl2, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-396 
                 3,5-Br2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-397 
                 3,5-Br2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-398 
                 3,5-Br2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-399 
                 3,5-Br2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-400 
                 3,5-Br2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-401 
                 3,5-Br2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-402 
                 3,5-Br2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-403 
                 3,5-Br2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-404 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-405 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-406 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-407 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-408 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-409 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-410 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-411 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-412 
                 3-Cl, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-413 
                 3-Cl, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-414 
                 3-Cl, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-415 
                 3-Cl, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-416 
                 3-Cl, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-417 
                 3-Cl, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-418 
                 3-Cl, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-419 
                 3-Cl, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-420 
                 3,5-Cl2 
                 NCH3 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-421 
                 3,5-Cl2 
                 NCH3 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-422 
                 3,5-Cl2 
                 NCH3 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-423 
                 3,5-Cl2 
                 NCH3 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-424 
                 3,5-Cl2 
                 NCH3 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 3-425 
                 3,5-Cl2 
                 NCH3 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-426 
                 3,5-Cl2 
                 NCH3 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-427 
                 3,5-Cl2 
                 NCH3 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHCH3 
               
               
                 3-428 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 3-429 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)CH3 
                 CH2 
               
               
                 3-430 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 3-431 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)CH2CF3 
                 CH2 
               
               
                 3-432 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)Pr-c 
                 CH2 
               
               
                 3-433 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)NHCH3 
                 CH2 
               
               
                 3-434 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)NHC2H5 
                 CH2 
               
               
                 3-435 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)NHPr-c 
                 CH2 
               
               
                 3-436 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2  
                 CHNH(C═O)NHCH2CCH 
                 CH2 
               
               
                 3-437 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 3-438 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
                 CH2 
               
               
                 3-439 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 3-440 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
                 CH2 
               
               
                 3-441 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
                 CH2 
               
               
                 3-442 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
                 CH2 
               
               
                 3-443 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
                 CH2 
               
               
                 3-444 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-c 
                 CH2 
               
               
                 3-445 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
                 CH2 
               
               
                 3-446 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 3-447 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)CH3 
                 CH2 
               
               
                 3-448 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 3-449 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)CH2CF3 
                 CH2 
               
               
                 3-450 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)Pr-c 
                 CH2 
               
               
                 3-451 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)NHCH3 
                 CH2 
               
               
                 3-452 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)NHC2H5 
                 CH2 
               
               
                 3-453 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)NHPr-c 
                 CH2 
               
               
                 3-454 
                 3,5-Cl2  
                 CH2 
                 H 
                 — 
                 CH2  
                 CHNH(C═O)NHCH2CCH 
                 CH2 
               
               
                 3-455 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 3-456 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
                 CH2 
               
               
                 3-457 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 3-458 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
                 CH2 
               
               
                 3-459 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
                 CH2 
               
               
                 3-460 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
                 CH2 
               
               
                 3-461 
                 3,5-Cl2  
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
                 CH2 
               
               
                 3-462 
                 3,5-Cl2  
                 CH2 
                 H 
                 CH2  
                 CH2  
                 CHNH(C═O)NHPr-c 
                 CH2 
               
               
                 3-463 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
                 CH2 
               
               
                 3-464 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 3-465 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)CH3 
                 CH2 
               
               
                 3-466 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 3-467 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)CH2CF3 
                 CH2 
               
               
                 3-468 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)Pr-c 
                 CH2 
               
               
                 3-469 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)NHCH3 
                 CH2 
               
               
                 3-470 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)NHC2H5 
                 CH2 
               
               
                 3-471 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)NHPr-c 
                 CH2 
               
               
                 3-472 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2  
                 CHNH(C═O)NHCH2CCH 
                 CH2 
               
               
                 3-473 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 3-474 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
                 CH2 
               
               
                 3-475 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 3-476 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
                 CH2 
               
               
                 3-477 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
                 CH2 
               
               
                 3-478 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
                 CH2 
               
               
                 3-479 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
                 CH2 
               
               
                 3-480 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-c 
                 CH2 
               
               
                 3-481 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
                 CH2 
               
               
                 3-482 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 3-483 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)CH3 
                 CH2 
               
               
                 3-484 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 3-485 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)CH2CF3 
                 CH2 
               
               
                 3-486 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)Pr-c 
                 CH2 
               
               
                 3-487 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)NHCH3 
                 CH2 
               
               
                 3-488 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)NHC2H5 
                 CH2 
               
               
                 3-489 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)NHPr-c 
                 CH2 
               
               
                 3-490 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
                 CH2 
               
               
                 3-491 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 3-492 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
                 CH2 
               
               
                 3-493 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 3-494 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
                 CH2 
               
               
                 3-495 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
                 CH2 
               
               
                 3-496 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
                 CH2 
               
               
                 3-497 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
                 CH2 
               
               
                 3-498 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-c 
                 CH2 
               
               
                 3-499 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
                 CH2 
               
               
                 3-500 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH2 
               
               
                 3-501 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH3 
               
               
                 3-502 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 3-503 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 3-504 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 3-505 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHCH3 
               
               
                 3-506 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 3-507 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHPr-c 
               
               
                 3-508 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHCH2CCH 
               
               
                 3-509 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH2 
               
               
                 3-509 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH3 
               
               
                 3-511 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 3-512 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 3-513 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 3-514 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHCH3 
               
               
                 3-515 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 3-516 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHPr-c 
               
               
                 3-517 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHCH2CCH 
               
               
                 3-518 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH2 
               
               
                 3-519 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH3 
               
               
                 3-520 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 3-521 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 3-522 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 3-523 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHCH3 
               
               
                 3-524 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 3-525 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHPr-c 
               
               
                 3-526 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHCH2CCH 
               
               
                 3-527 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH2 
               
               
                 3-528 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH3 
               
               
                 3-529 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 3-530 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 3-531 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 3-532 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHCH3 
               
               
                 3-533 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 3-534 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHPr-c 
               
               
                 3-535 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHCH2CCH 
               
               
                 3-536 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH2 
               
               
                 3-537 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH3 
               
               
                 3-538 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 3-539 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 3-540 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 3-541 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHCH3 
               
               
                 3-542 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 3-543 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHPr-c 
               
               
                 3-544 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHCH2CCH 
               
               
                 3-545 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH2 
               
               
                 3-546 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH3 
               
               
                 3-547 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 3-548 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 3-549 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 3-550 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHCH3 
               
               
                 3-551 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 3-552 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHPr-c 
               
               
                 3-553 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHCH2CCH 
               
               
                 3-554 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CNH2 
                 CH 
               
               
                 3-555 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CNH(C═O)CH3 
                 CH 
               
               
                 3-556 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
                 CH 
               
               
                 3-557 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CNH(C═O)CH2CF3 
                 CH 
               
               
                 3-558 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
                 CH 
               
               
                 3-559 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CNH(C═O)NHCH3 
                 CH 
               
               
                 3-560 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
                 CH 
               
               
                 3-561 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CNH(C═O)NHPr-c 
                 CH 
               
               
                 3-562 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH 
                 CH 
                 CNH(C═O)NHCH2CCH 
                 CH 
               
               
                 3-563 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH2 
               
               
                 3-564 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH3 
               
               
                 3-565 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)C2H5 
               
               
                 3-566 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH2CF3 
               
               
                 3-567 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)Pr-c 
               
               
                 3-568 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)NHCH3 
               
               
                 3-569 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)NHC2H5 
               
               
                 3-570 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)NHPr-c 
               
               
                 3-571 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-572 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH2 
               
               
                 3-573 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH3 
               
               
                 3-574 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)C2H5 
               
               
                 3-575 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH2CF3 
               
               
                 3-576 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)Pr-c 
               
               
                 3-577 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)NHCH3 
               
               
                 3-578 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)NHC2H5 
               
               
                 3-579 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)NHPr-c 
               
               
                 3-580 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-581 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH2 
               
               
                 3-582 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH3 
               
               
                 3-583 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)C2H5 
               
               
                 3-584 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH2CF3 
               
               
                 3-585 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)Pr-c 
               
               
                 3-586 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)NHCH3 
               
               
                 3-587 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)NHC2H5 
               
               
                 3-588 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)NHPr-c 
               
               
                 3-589 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-590 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH2 
               
               
                 3-591 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)CH3 
               
               
                 3-592 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)C2H5 
               
               
                 3-593 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 3-594 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 3-595 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)NHCH3 
               
               
                 3-596 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 3-597 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)NHPr-c 
               
               
                 3-598 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)NHCH2CCH 
               
               
                 3-599 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 N 
                 CNH2 
               
               
                 3-600 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 N 
                 CNH(C═O)CH3 
               
               
                 3-601 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 N 
                 CNH(C═O)C2H5 
               
               
                 3-602 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 3-603 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 3-604 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 N 
                 CNH(C═O)NHCH3 
               
               
                 3-605 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 3-606 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 N 
                 CNH(C═O)NHPr-c 
               
               
                 3-607 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 N 
                 CNH(C═O)NHCH2CCH 
               
               
                 3-608 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH2 
               
               
                 3-609 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH3 
               
               
                 3-610 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)C2H5 
               
               
                 3-611 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 3-612 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 3-613 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)NHCH3 
               
               
                 3-614 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 3-615 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)NHPr-c 
               
               
                 3-616 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)NHCH2CCH 
               
               
                 3-617 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH2 
               
               
                 3-618 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH3 
               
               
                 3-619 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)C2H5 
               
               
                 3-620 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 3-621 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 3-622 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)NHCH3 
               
               
                 3-623 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 3-624 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)NHPr-c 
               
               
                 3-625 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)NHCH2CCH 
               
               
                 3-626 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CNH2 
                 N 
               
               
                 3-627 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CNH(C═O)CH3 
                 N 
               
               
                 3-628 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
                 N 
               
               
                 3-629 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CNH(C═O)CH2CF3 
                 N 
               
               
                 3-630 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
                 N 
               
               
                 3-631 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CNH(C═O)NHCH3 
                 N 
               
               
                 3-632 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
                 N 
               
               
                 3-633 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CNH(C═O)NHPr-c 
                 N 
               
               
                 3-634 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CNH(C═O)NHCH2CCH 
                 N 
               
               
                 3-635 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 NCO2CH3 
               
               
                 3-636 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 NCO2C4H9-tert 
               
               
                 3-637 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH3 
               
               
                 3-638 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHC2H5 
               
               
                 3-639 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHPr-n 
               
               
                 3-640 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHPr-i 
               
               
                 3-641 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHPr-c 
               
               
                 3-642 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2Pr-c 
               
               
                 3-643 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CF3 
               
               
                 3-644 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2(py-2-yl) 
               
               
                 3-645 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CHCH2 
               
               
                 3-646 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CCH 
               
               
                 3-647 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NH(2-Cl—Ph) 
               
               
                 3-648 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NH(3-Cl—Ph) 
               
               
                 3-649 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NH(4-Cl—Ph) 
               
               
                 3-650 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2(2-Cl—Ph) 
               
               
                 3-651 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)N(CH3)2 
               
               
                 3-652 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═S)NHCH3 
               
               
                 3-653 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 NCO2CH3 
               
               
                 3-654 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 NCO2C4H9-tert 
               
               
                 3-655 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH3 
               
               
                 3-656 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHC2H5 
               
               
                 3-657 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHPr-n 
               
               
                 3-658 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHPr-i 
               
               
                 3-659 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHPr-c 
               
               
                 3-660 
                 3,5-Cl2 
                 O 
                 H 
                 CH2  
                 CH2 
                 CH2 
                 N(C═O)NHCH2Pr-c 
               
               
                 3-661A 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CF3 
               
               
                 3-661B 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHBu-c 
               
               
                 3-662 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH2(py-2-yl) 
               
               
                 3-663 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CHCH2 
               
               
                 3-664 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CCH 
               
               
                 3-665 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NH(2-Cl—Ph) 
               
               
                 3-666 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NH(3-Cl—Ph) 
               
               
                 3-667 
                 3,5-Cl2 
                 O 
                 H 
                 CH2  
                 CH2 
                 CH2 
                 N(C═O)NH(4-Cl—Ph) 
               
               
                 3-668 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH2(2-Cl—Ph) 
               
               
                 3-669 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)N(CH3)2 
               
               
                 3-670 
                 3,5-Cl2 
                 O 
                 H 
                 CH2  
                 CH2 
                 CH2 
                 N(C═S)NHCH3 
               
               
                 3-671 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 NCO2CH3 
               
               
                 3-672 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 NCO2C4H9-tert 
               
               
                 3-673 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH3 
               
               
                 3-674 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHC2H5 
               
               
                 3-675 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHPr-n 
               
               
                 3-676 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHPr-i 
               
               
                 3-677 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHPr-c 
               
               
                 3-678 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2Pr-c 
               
               
                 3-679 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CF3 
               
               
                 3-680 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2(py-2-yl) 
               
               
                 3-681 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CHCH2 
               
               
                 3-682 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CCH 
               
               
                 3-683 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NH(2-Cl—Ph) 
               
               
                 3-684 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NH(3-Cl—Ph) 
               
               
                 3-685 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NH(4-Cl—Ph) 
               
               
                 3-686 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2(2-Cl—Ph) 
               
               
                 3-687 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)N(CH3)2 
               
               
                 3-688 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═S)NHCH3 
               
               
                 3-689 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 NCO2CH3 
               
               
                 3-690 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 NCO2C4H9-tert 
               
               
                 3-691 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH3 
               
               
                 3-692 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHC2H5 
               
               
                 3-693 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHPr-n 
               
               
                 3-694 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHPr-i 
               
               
                 3-695 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHPr-c 
               
               
                 3-696 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2Pr-c 
               
               
                 3-697 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CF3 
               
               
                 3-698 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2(py-2-yl) 
               
               
                 3-699 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CHCH2 
               
               
                 3-700 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CCH 
               
               
                 3-701 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NH(2-Cl—Ph) 
               
               
                 3-702 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NH(3-Cl—Ph) 
               
               
                 3-703 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NH(4-Cl—Ph) 
               
               
                 3-704 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2(2-Cl—Ph) 
               
               
                 3-705 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)N(CH3)2 
               
               
                 3-706 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═S)NHCH3 
               
               
                 3-707 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 NCO2CH3 
               
               
                 3-708 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 NCO2C4H9-tert 
               
               
                 3-709 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH3 
               
               
                 3-710 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHC2H5 
               
               
                 3-711 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHPr-n 
               
               
                 3-712 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHPr-i 
               
               
                 3-713 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHPr-c 
               
               
                 3-714 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2Pr-c 
               
               
                 3-715 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CF3 
               
               
                 3-716 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2(py-2-yl) 
               
               
                 3-717 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CHCH2 
               
               
                 3-718 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CCH 
               
               
                 3-719 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NH(2-Cl—Ph) 
               
               
                 3-720 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NH(3-Cl—Ph) 
               
               
                 3-721 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NH(4-Cl—Ph) 
               
               
                 3-722 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2(2-Cl—Ph) 
               
               
                 3-723 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)N(CH3)2 
               
               
                 3-724 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═S)NHCH3 
               
               
                 3-725 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH3 
               
               
                 3-726 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHC2H5 
               
               
                 3-727 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHPr-c 
               
               
                 3-728 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CF3 
               
               
                 3-729 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CCH 
               
               
                 3-730 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH3 
               
               
                 3-731 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHC2H5 
               
               
                 3-732 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHPr-c 
               
               
                 3-733 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CF3 
               
               
                 3-734 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CCH 
               
               
                 3-735 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH3 
               
               
                 3-736 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHC2H5 
               
               
                 3-737 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHPr-c 
               
               
                 3-738 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CF3 
               
               
                 3-739 
                 3,5-Cl2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CCH 
               
               
                 3-740 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH3 
               
               
                 3-741 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHC2H5 
               
               
                 3-742 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHPr-c 
               
               
                 3-743 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CF3 
               
               
                 3-744 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CCH 
               
               
                 3-745 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH3 
               
               
                 3-746 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHC2H5 
               
               
                 3-747 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHPr-c 
               
               
                 3-748 
                 3,4,5-Cl3 
                 CH2 
                 II 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CF3 
               
               
                 3-749 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CCH 
               
               
                 3-750 
                 3,4,5-Cl3 
                 NCH3 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH3 
               
               
                 3-751 
                 3,4,5-Cl3 
                 NCH3 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHC2H5 
               
               
                 3-752 
                 3,4,5-Cl3 
                 NCH3 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHPr-c 
               
               
                 3-753 
                 3,4,5-Cl3 
                 NCH3 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CF3 
               
               
                 3-754 
                 3,4,5-Cl3 
                 NCH3 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CCH 
               
               
                 3-755 
                 3,5-(CF3)2 
                 NCH3 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH3 
               
               
                 3-756 
                 3,5-(CF3)2 
                 NCH3 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHC2H5 
               
               
                 3-757 
                 3,5-(CF3)2 
                 NCH3 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHPr-c 
               
               
                 3-758 
                 3,5-(CF3)2 
                 NCH3 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CF3 
               
               
                 3-759 
                 3,5-(CF3)2 
                 NCH3 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHCH2CCH 
               
               
                 3-760 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 NCO2CH3 
               
               
                 3-761 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 N(C═O)NHCH3 
               
               
                 3-762 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 N(C═O)NHC2H5 
               
               
                 3-763 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 N(C═O)NHPr-n 
               
               
                 3-764 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 N(C═O)NHPr-i 
               
               
                 3-765 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 N(C═O)NHPr-c 
               
               
                 3-766 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 N(C═O)NHCH2Pr-c 
               
               
                 3-767 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 N(C═O)NHCH2CF3 
               
               
                 3-768 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 N(C═O)NHCH2(py-2-yl) 
               
               
                 3-769 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 N(C═O)NHCH2CHCH2 
               
               
                 3-770 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 N(C═O)NHCH2CCH 
               
               
                 3-771 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 N(C═O)NH(2-Cl—Ph) 
               
               
                 3-772 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 N(C═O)NH(3-Cl—Ph) 
               
               
                 3-773 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 N(C═O)NH(4-Cl—Ph) 
               
               
                 3-774 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 N(C═O)NHCH2(2-Cl—Ph) 
               
               
                 3-775 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 N(C═O)N(CH3)2 
               
               
                 3-776 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 N(C═S)NHCH3 
               
               
                 3-777 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 CCl 
                 N 
               
               
                 3-778 
                 3,5-Cl2 
                 O 
                 H 
                 C═O  
                 NH 
                 NH 
                 CH2 
               
               
                 3-779 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 C═O 
                 NH 
               
               
                 3-780 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NN═C(CH3)2 
               
               
                 3-781 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NH 
                 C═O 
                 CHSCH3 
               
               
                 3-782 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 CF2 
                 O 
               
               
                 3-783 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NH 
                 C═O 
                 CHSO2CH3 
               
               
                 3-784 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 C═CHN(CH3)2 
                 C═O 
               
               
                 3-785 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 CHOH 
               
               
                 3-786 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 NH 
                 CHNH(C═O)NHC2H5 
               
               
                 3-787 
                 3,5-F2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-788 
                 3,5-Br2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-789 
                 3,5-I2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-790 
                 3-F 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-791 
                 3-Cl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-792 
                 3-Br 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-793 
                 3-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-794 
                 4-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-795 
                 3-NO2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-796 
                 3-CH3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-797 
                 3-CH3O 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-798 
                 3-CN 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-799 
                 3-CF3O 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-800 
                 3-CH3S 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-801 
                 3-CH3S(O) 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-802 
                 3-CH3S(O)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-803 
                 3-CF3S 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-804 
                 3-CF3S(O) 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-805 
                 3-CF3S(O)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-806 
                 3-OH 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-807 
                 3-SH 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-808 
                 3-NH2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-809 
                 3-NHCOCH3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-810 
                 3-NHCOCF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-811 
                 3-NHCO2CH3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-812 
                 3-NHCO2CH2CCl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-813 
                 3-NHSO2CH3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-814 
                 3-NHSO2CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-815 
                 3-NHCH3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-816 
                 3-N(CH3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-817 
                 3-NHCOBu-t 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-818 
                 3-Cl, 4-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-819 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-820 
                 3-Cl, 5-SCF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-821 
                 3,4,5-F3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-822 
                 3,4,5-Br3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-823 
                 3,5-Cl2, 4-Br 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-824 
                 3,5-Br2, 4-Cl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-825 
                 3,5-Cl2, 4-NH2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-826 
                 3,5-Br2, 4-NH2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-827 
                 3,5-Cl2, 4-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 3-828 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NHBu-c 
               
               
                 3-829 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(1,3-oxazolin)-2-yl 
               
               
                 3-830 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHO(C═O)CH3 
               
               
                 3-831 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 3-832 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)N(CH3)2 
               
               
                 3-833 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHCO(Ph-2-Cl) 
               
               
                 3-834 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHCO(Ph-3-Cl) 
               
               
                 3-835 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Bu-c 
               
               
                 3-836 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CF3 
               
               
                 3-837 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NH2 
               
               
                 3-838 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-c 
               
               
                 3-839 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)(azetidine-1) 
               
               
                 3-840 
                 3,5-(CF3)2  
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
               
               
                 3-841 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NH2 
               
               
                 3-842 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHSO2CHF2 
               
               
                 3-843 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHSO2CH2CF3 
               
               
                 3-844 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)(pyrrolidine-1) 
               
               
                 3-845 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2(C═O)CH3 
               
               
                 3-846 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CN 
               
               
                 3-847 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH═CH2 
               
               
                 3-848 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHCO(furan-2) 
               
               
                 3-849 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CN 
               
               
                 3-850 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2N(CH3)2 
               
               
                 3-851 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2Pr-c 
               
               
                 3-852 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-n 
               
               
                 3-853 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2SCH3 
               
               
                 3-854 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2CH3 
               
               
                 3-855 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHCO(2,2-F2—Pr-c) 
               
               
                 3-856 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NH(2-F—Pr-c) 
               
               
                 3-857 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CH(1,2,3-triazole-4-TMS)-1 
               
               
                 3-858 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CH(1,2,3-triazole)-1 
               
               
                 3-859 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPh 
               
               
                 3-860 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NH(Ph—Cl-2) 
               
               
                 3-861 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NH(Ph—CF3-2) 
               
               
                 3-862 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHOCH3 
               
               
                 3-863 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHOC2H5 
               
               
                 3-864 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHOCH2CH═CH2 
               
               
                 3-865 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NCH3OCH3 
               
               
                 3-866 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH(CH3)(C═O)CH3 
               
               
                 3-867 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)(N—CH3-pyrrolidine-2) 
               
               
                 3-868 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 3-869 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Bu-n 
               
               
                 3-870 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-n 
               
               
                 3-871 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CH(succinimide-1) 
               
               
                 3-872 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2SCH3 
               
               
                 3-873 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)CH3 
               
               
                 3-874 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2CH3 
               
               
                 3-875 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2SC2H5 
               
               
                 3-876 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CH═CH2 
               
               
                 3-877 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-878 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-n 
               
               
                 3-879 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 3-880 
                 3,5-Cl2, 4-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-881 
                 3-CF3, 4-F 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-882 
                 3-Cl 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-883 
                 3,5-F2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-884 
                 4-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-885 
                 3-NO2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-886 
                 3-CN 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-887 
                 3-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-888 
                 3-Cl, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-889 
                 3-SCH3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-890 
                 3,4-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-891 
                 3,4,5-F3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-892 
                 3-CF3,5-NO2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-893 
                 3-OCF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-894 
                 3-OCH3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-895 
                 4-NO2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-896 
                 3-NO2, 5-CH3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-897 
                 3,5-Cl2, 4-CF3  
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-898 
                 3-CF3, 4-F 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-899 
                 3-Cl, 4-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-900 
                 3,4-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-901 
                 3-CN 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-902 
                 3-NO2, 4-CH3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-903 
                 4-NO2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-904 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-905 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-906 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-907 
                 3,5-Cl2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-908 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-909 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 3-910 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CNHCO2C4H9-tert 
                 CH 
               
               
                 3-911 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CNH2 
                 CH 
               
               
                 3-912 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CNH(C═O)CH3 
                 CH 
               
               
                 3-913 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
                 CH 
               
               
                 3-914 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
                 CH 
               
               
                 3-915 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CNH(C═O)CH2CF3 
                 CH 
               
               
                 3-916 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
                 CH 
               
               
                 3-917 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CN 
               
               
                 3-918 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CN 
               
               
                 3-919 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2(C═O)CH3 
               
               
                 3-920 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CH 
                 CNHCO2C4H9-tert 
               
               
                 3-921 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 CNH2 
                 CH 
               
               
                 3-922 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
               
               
                 3-923 
                 3-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHO(C═O)CH3 
               
               
                 3-924 
                 3-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 3-925 
                 3-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-926 
                 3-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-927 
                 3-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-928 
                 3-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 3-929 
                 3-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CH═CH2 
               
               
                 3-930 
                 3-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2SCH3 
               
               
                 3-931 
                 3-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)CH3 
               
               
                 3-932 
                 3-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2CH3 
               
               
                 3-933 
                 3-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-c 
               
               
                 3-934 
                 3-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 3-935 
                 3-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHO(C═O)CH3 
               
               
                 3-936 
                 3-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 3-937 
                 3-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 3-938 
                 3-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 3-939 
                 3-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 3-940 
                 3-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 3-941 
                 3-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CH═CH2 
               
               
                 3-942 
                 3-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2SCH3 
               
               
                 3-943 
                 3-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)CH3 
               
               
                 3-944 
                 3-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2CH3 
               
               
                 3-945 
                 3-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHPr-c 
               
               
                 3-946 
                 3-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 Example 
                 (X) m   
                 A 
                 (Y) n   
                 W 1   
                 W 2   
                 W 3   
                 W 4   
               
               
                   
               
               
                 4-1 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH2 
               
               
                 4-2 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)CH3 
               
               
                 4-3 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-4 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-5 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 4-6 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)Pr-i 
               
               
                 4-7 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)CH2Pr-c 
               
               
                 4-8 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)CH2SMe 
               
               
                 4-9 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)CH2SOMe 
               
               
                 4-10 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)CH2SO2Me 
               
               
                 4-11 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)CF3 
               
               
                 4-12 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)NHCH3 
               
               
                 4-13 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 4-14 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)NHCH2CCH 
               
               
                 4-15 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═S)C2H5 
               
               
                 4-16 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═S)NHCH3 
               
               
                 4-17 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)OCH3 
               
               
                 4-18 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)OC4H9-tert 
               
               
                 4-19 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CN((C═O)Pr-i)2 
               
               
                 4-20 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH2 
               
               
                 4-21 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)CH3 
               
               
                 4-22 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-23 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-24 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 4-25 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)CH2Pr-c 
               
               
                 4-26 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)CH2SMe 
               
               
                 4-27 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)CH2SOMe 
               
               
                 4-28 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)CH2SO2Me 
               
               
                 4-29 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)NHCH3 
               
               
                 4-30 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 4-31 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)NHCH2CCH 
               
               
                 4-32 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═S)C2H5 
               
               
                 4-33 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═S)NHCH3 
               
               
                 4-34 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)OC4H9-tert 
               
               
                 4-35 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CHNH(C═O)NHBu-t 
               
               
                 4-36 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CHNH(C═O)NHBu-c 
               
               
                 4-37 
                 3,5-Br2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-38 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-39 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-40 
                 3-CF3 
                 O 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-41 
                 3,5-Cl2 
                 O 
                 H 
                 CNH2 
                 N 
                 O 
                 — 
               
               
                 4-42 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)C2H5 
                 N 
                 O 
                 — 
               
               
                 4-43 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)Pr-i 
                 N 
                 O 
                 — 
               
               
                 4-44 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)CF3 
                 N 
                 O 
                 — 
               
               
                 4-45 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)CH2CF3 
                 N 
                 O 
                 — 
               
               
                 4-46 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)NHC2H5 
                 N 
                 O 
                 — 
               
               
                 4-47 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)NHPr-i 
                 N 
                 O 
                 — 
               
               
                 4-48 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)OCH3 
                 N 
                 O 
                 — 
               
               
                 4-49 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)OPh 
                 N 
                 O 
                 — 
               
               
                 4-50 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 N 
                 CNH2 
               
               
                 4-51 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-52 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-53 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 4-54 
                 3,5-Cl2 
                 O 
                 H 
                 CNH2 
                 N 
                 NCH3 
                 — 
               
               
                 4-55 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)C2H5 
                 N 
                 NCH3 
                 — 
               
               
                 4-56 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)Pr-i 
                 N 
                 NCH3 
                 — 
               
               
                 4-57 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)CF3 
                 N 
                 NCH3 
                 — 
               
               
                 4-58 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)CH2CF3 
                 N 
                 NCH3 
                 — 
               
               
                 4-59 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)NHC2H5 
                 N 
                 NCH3 
                 — 
               
               
                 4-60 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)NHPr-i 
                 N 
                 NCH3 
                 — 
               
               
                 4-61 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)OCH3 
                 N 
                 NCH3 
                 — 
               
               
                 4-62 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)OPh 
                 N 
                 NCH3 
                 — 
               
               
                 4-63 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 SO2 
                 N 
                 CNH2 
               
               
                 4-64 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 SO2 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-65 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 SO2 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-66 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 SO2 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 4-67 
                 3,5-Cl2 
                 O 
                 H 
                 CNH2 
                 N 
                 SO2 
                 — 
               
               
                 4-68 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)C2H5 
                 N 
                 SO2 
                 — 
               
               
                 4-69 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)CH2CF3 
                 N 
                 SO2 
                 — 
               
               
                 4-70 
                 3,5-Cl2 
                 O 
                 H 
                 CNH(C═O)NHC2H5 
                 N 
                 SO2 
                 — 
               
               
                 4-71 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 NCH3 
                 N 
                 CNH2 
               
               
                 4-72 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 NCH3 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-73 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 NCH3 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-74 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 NCH3 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 4-75 
                 3,5-Br2 
                 O 
                 H 
                 — 
                 NCH3 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-76 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 NCH3 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-77 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 NCH3 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-78 
                 3-CF3 
                 O 
                 H 
                 — 
                 NCH3 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-79 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 SO2 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-80 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 SO2 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-81 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 SO2 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-82 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH2 
               
               
                 4-83 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)CH3 
               
               
                 4-84 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-85 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-86 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 4-87 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)CH2Pr-c 
               
               
                 4-88 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)CH2SMe 
               
               
                 4-89 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)CH2SOMe 
               
               
                 4-90 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)CH2SO2Me 
               
               
                 4-91 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)NHCH2CCH 
               
               
                 4-92 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)OC4H9-tert 
               
               
                 4-93 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-94 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-95 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 4-96 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)CH2SO2Me 
               
               
                 4-97 
                 3,5-Br2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-98 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-99 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-100 
                 3-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-101 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH2 
               
               
                 4-102 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 4-103 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 4-104 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-105 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 4-106 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 4-107 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)CH2SMe 
               
               
                 4-108 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)CH2SOMe 
               
               
                 4-109 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)CH2SO2Me 
               
               
                 4-110 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 4-111 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 4-112 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)OC4H9-tert 
               
               
                 4-113 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 4-114 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHO(C═O)CH3 
               
               
                 4-115 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-116 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 4-117 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)CH2SO2Me 
               
               
                 4-118 
                 3,5-Br2 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-119 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-120 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-121 
                 3-CF3 
                 O 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-122 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH2 
               
               
                 4-123 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 4-124 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-125 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 4-126 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 4-127 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 O 
                 CH2 
                 CHNH(C═O)—OC4H9-tert 
               
               
                 4-128 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH2 
               
               
                 4-129 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 4-130 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 4-131 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-132 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 4-133 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 4-134 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)—CH2SMe 
               
               
                 4-135 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)—CH2SOMe 
               
               
                 4-136 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)—CH2SO2Me 
               
               
                 4-137 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)—NHC2H5 
               
               
                 4-138 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)—NHCH2CCH 
               
               
                 4-139 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)—OC4H9-tert 
               
               
                 4-140 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 4-141 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHO(C═O)CH3 
               
               
                 4-142 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-143 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 4-144 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)CH2SO2Me 
               
               
                 4-145 
                 3,5-Br2 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-146 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-147 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-148 
                 3-CF3 
                 O 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-149 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH2 
               
               
                 4-150 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 4-151 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-152 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 4-153 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)—NHC2H5 
               
               
                 4-154 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 S 
                 CH2 
                 CHNH(C═O)—OC4H9-tert 
               
               
                 4-155 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH2 
               
               
                 4-156 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 4-157 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 4-158 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-159 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 4-160 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 4-161 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)CH2—SMe 
               
               
                 4-162 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)CH2—SOMe 
               
               
                 4-163 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)CH2—SO2Me 
               
               
                 4-164 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)NH—C2H5 
               
               
                 4-165 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)NH—CH2CCH 
               
               
                 4-166 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)O—C4H9-tert 
               
               
                 4-167 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 4-168 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHO(C═O)CH3 
               
               
                 4-169 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-170 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 4-171 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)—CH2SO2Me 
               
               
                 4-172 
                 3,5-Br2 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-173 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-174 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)—CH2CF3 
               
               
                 4-175 
                 3-CF3 
                 O 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)—CH2CF3 
               
               
                 4-176 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH2 
               
               
                 4-177 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 4-178 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 4-179 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 4-180 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)NH—C2H5 
               
               
                 4-181 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 NCH3 
                 CH2 
                 CHNH(C═O)O—C4H9-tert 
               
               
                 4-182 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═NH(C═O)—C2H5 
               
               
                 4-183 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═NHCOCH2CF3 
               
               
                 4-184 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 O 
                 C═NHC(C═O)—NHC2H5 
               
               
                 4-185 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═NCOC2H5 
               
               
                 4-186 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═NHCOCH2CF3 
               
               
                 4-187 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═NCOPr-c 
               
               
                 4-188 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2(py-2-yl) 
                 C═NHC(C═O)—NHC2H5 
               
               
                 4-189 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NCH3 
                 C═NCOC2H5 
               
               
                 4-190 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NCH3 
                 C═NHCOCH2CF3 
               
               
                 4-191 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NCH3 
                 C═NCOPr-c 
               
               
                 4-192 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NCH3 
                 C═NHC(C═O)—NHC2H5 
               
               
                 4-193 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2CF3 
                 C═NCOC2H5 
               
               
                 4-194 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2CF3 
                 C═NHCOCH2CF3 
               
               
                 4-195 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2CF3 
                 C═NCOPr-c 
               
               
                 4-196 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 NCH2CF3 
                 C═NHC(C═O)—NHC2H5 
               
               
                 4-197 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 N 
                 CHNH2 
               
               
                 4-198 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH 
                 N 
                 CHNH(C═O)C2H5 
               
               
                 4-199 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH 
                 N 
                 CHNH(C═O)CH2CF3 
               
               
                 4-200 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH 
                 N 
                 CHNH(C═O)Pr-c 
               
               
                 4-201 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH 
                 N 
                 CHNH(C═O)—NHC2H5 
               
               
                 4-202 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH 
                 N 
                 CHNH(C═O)—OC4H9-tert 
               
               
                 4-203 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)—OC4H9-tert 
               
               
                 4-204 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-205 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-206 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 4-207 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)—CH2SO2Me 
               
               
                 4-208 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-209 
                 3,5-Br2 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-210 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-211 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-212 
                 3-CF3 
                 O 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-213 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 N 
                 CNH2 
               
               
                 4-214 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-215 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-216 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 4-217 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 4-218 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)—OC4H9-tert 
               
               
                 4-219 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 N 
                 CH 
                 CNH2 
               
               
                 4-220 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 N 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 4-221 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 N 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 4-222 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 N 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 4-223 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 N 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 4-224 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 N 
                 CH 
                 CNH(C═O)O—C4H9-tert 
               
               
                 4-225 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 N 
                 CH 
                 N 
                 CNH2 
               
               
                 4-226 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 N 
                 CH 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-227 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 N 
                 CH 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-228 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 N 
                 CH 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 4-229 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 N 
                 CH 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 4-230 
                 3,5-(CF3)2 
                 CH2 
                 H 
                 N 
                 CH 
                 N 
                 CNH(C═O)O—C4H9-tert 
               
               
                 4-231 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH2 
               
               
                 4-232 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH3 
               
               
                 4-233 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-234 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-235 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 4-236 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2Pr-c 
               
               
                 4-237 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2SMe 
               
               
                 4-238 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2—SOMe 
               
               
                 4-239 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)—CH2SO2Me 
               
               
                 4-240 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)NH—CH2CCH 
               
               
                 4-241 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)NH—C2H5 
               
               
                 4-242 
                 3,5-Cl2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)O—C4H9-tert 
               
               
                 4-243 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-244 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-245 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 4-246 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)—CH2SO2Me 
               
               
                 4-247 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-248 
                 3,5-Br2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-249 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-250 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-251 
                 3-CF3 
                 O 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-252 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 N 
                 N 
                 CNH2 
               
               
                 4-253 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-254 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-255 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 4-256 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 4-257 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)O—C4H9-tert 
               
               
                 4-258 
                 3,5-(CF3)2 
                 O 
                 H 
                 N 
                 CH 
                 N 
                 CNH2 
               
               
                 4-259 
                 3,5-(CF3)2 
                 O 
                 H 
                 N 
                 CH 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-260 
                 3,5-(CF3)2 
                 O 
                 H 
                 N 
                 CH 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-261 
                 3,5-(CF3)2 
                 O 
                 H 
                 N 
                 CH 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 4-262 
                 3,5-(CF3)2 
                 O 
                 H 
                 N 
                 CH 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 4-263 
                 3,5-(CF3)2 
                 O 
                 H 
                 N 
                 CH 
                 N 
                 CNH(C═O)O—C4H9-tert 
               
               
                 4-264 
                 3,5-Cl2 
                 CH2 
                 H 
                 N 
                 N 
                 CH 
                 CNH2 
               
               
                 4-265 
                 3,5-Cl2 
                 CH2 
                 H 
                 N 
                 N 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 4-266 
                 3,5-Cl2 
                 CH2 
                 H 
                 N 
                 N 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 4-267 
                 3,5-Cl2 
                 CH2 
                 H 
                 N 
                 N 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 4-268 
                 3,5-Cl2 
                 CH2 
                 H 
                 N 
                 N 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 4-269 
                 3,5-Cl2 
                 CH2 
                 H 
                 N 
                 N 
                 CH 
                 CNH(C═O)O—C4H9-tert 
               
               
                 4-270 
                 3,4,5-Cl3 
                 O 
                 H 
                 N 
                 N 
                 N 
                 CNH2 
               
               
                 4-271 
                 3,4,5-Cl3 
                 O 
                 H 
                 N 
                 N 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-272 
                 3,4,5-Cl3 
                 O 
                 H 
                 N 
                 N 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-273 
                 3,4,5-Cl3 
                 O 
                 H 
                 N 
                 N 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 4-274 
                 3,4,5-Cl3 
                 O 
                 H 
                 N 
                 N 
                 N 
                 CNH(C═O)NH—C2H5 
               
               
                 4-275 
                 3,4,5-Cl3 
                 O 
                 H 
                 N 
                 N 
                 N 
                 CNH(C═O)O—C4H9-tert 
               
               
                 4-276 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 N 
                 N 
                 N 
                 CNH2 
               
               
                 4-277 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 N 
                 N 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-278 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 N 
                 N 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-279 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 N 
                 N 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 4-280 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 N 
                 N 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 4-281 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 N 
                 N 
                 N 
                 CNH(C═O)O—C4H9-tert 
               
               
                 4-282 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 NCH3 
                 N 
                 CNH2 
               
               
                 4-283 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 NCH3 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-284 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 NCH3 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-285 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 NCH3 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 4-286 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 NCH3 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 4-287 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 NCH3 
                 N 
                 CNH(C═O)O—C4H9-tert 
               
               
                 4-288 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 O 
                 N 
                 CNH2 
               
               
                 4-289 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 O 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-290 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 O 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-291 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 O 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 4-292 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 O 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 4-293 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 O 
                 N 
                 CNH(C═O)O—C4H9-tert 
               
               
                 4-294 
                 3,4,5-Cl3 
                 S 
                 H 
                 CH2 
                 O 
                 N 
                 CNH2 
               
               
                 4-295 
                 3,4,5-Cl3 
                 S 
                 H 
                 CH2 
                 O 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-296 
                 3,4,5-Cl3 
                 S 
                 H 
                 CH2 
                 O 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-297 
                 3,4,5-Cl3 
                 S 
                 H 
                 CH2 
                 O 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 4-298 
                 3,4,5-Cl3 
                 S 
                 H 
                 CH2 
                 O 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 4-299 
                 3,4,5-Cl3 
                 S 
                 H 
                 CH2 
                 O 
                 N 
                 CNH(C═O)O—C4H9-tert 
               
               
                 4-300 
                 3,4,5-Cl3 
                 S 
                 H 
                 — 
                 O 
                 N 
                 CNH2 
               
               
                 4-301 
                 3,4,5-Cl3 
                 S 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)C2H5 
               
               
                 4-302 
                 3,4,5-Cl3 
                 S 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 4-303 
                 3,4,5-Cl3 
                 S 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 4-304 
                 3,4,5-Cl3 
                 S 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 4-305 
                 3,4,5-Cl3 
                 S 
                 H 
                 — 
                 O 
                 N 
                 CNH(C═O)O—C4H9-tert 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 Example 
                 (X) m   
                 A 
                 (Y) n   
                 W 1   
                 W 2   
                 W 3   
                 W 4   
               
               
                   
               
               
                 5-1 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH2 
               
               
                 5-2 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH3 
               
               
                 5-3 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)C2H5 
               
               
                 5-4 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2CF3 
               
               
                 5-5 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)Pr-c 
               
               
                 5-6 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)Pr-i 
               
               
                 5-7 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2Pr-c 
               
               
                 5-8 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2SMe 
               
               
                 5-9 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2S(═O)Me 
               
               
                 5-10 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-11 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CF3 
               
               
                 5-12 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)NHCH3 
               
               
                 5-13 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)NHC2H5 
               
               
                 5-14 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)NHCH2CCH 
               
               
                 5-15 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═S)C2H5 
               
               
                 5-16 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═S)NHCH3 
               
               
                 5-17 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)OCH3 
               
               
                 5-18 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-19 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHN((C═O)Pr-i)2 
               
               
                 5-20 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH2 
               
               
                 5-21 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)C2H5 
               
               
                 5-22 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2CF3 
               
               
                 5-23 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)Pr-c 
               
               
                 5-24 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-25 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)NHC2H5 
               
               
                 5-26 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-27 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH2 
               
               
                 5-28 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)C2H5 
               
               
                 5-29 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2CF3 
               
               
                 5-30 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)Pr-c 
               
               
                 5-31 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-32 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)NHC2H5 
               
               
                 5-33 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-34 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNH2 
               
               
                 5-35 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)C2H5 
               
               
                 5-36 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)CH2CF3 
               
               
                 5-37 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)Pr-c 
               
               
                 5-38 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-39 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)NHC2H5 
               
               
                 5-40 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-41 
                 3,4-Cl, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNH2 
               
               
                 5-42 
                 3,4-Cl, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)C2H5 
               
               
                 5-43 
                 3,4-Cl, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)CH2CF3 
               
               
                 5-44 
                 3,4-Cl, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)Pr-c 
               
               
                 5-45 
                 3,4-Cl, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-46 
                 3,4-Cl, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)NHC2H5 
               
               
                 5-47 
                 3,4-Cl, 5-CF3 
                 CH2 
                 H 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-48 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHF 
                 CHNH2 
               
               
                 5-49 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHF 
                 CHNH(C═O)C2H5 
               
               
                 5-50 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHF 
                 CHNH(C═O)CH2CF3 
               
               
                 5-51 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHF 
                 CHNH(C═O)Pr-c 
               
               
                 5-52 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHF 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-53 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHF 
                 CHNH(C═O)NHC2H5 
               
               
                 5-54 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHF 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-55 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHF 
                 CHNH2 
               
               
                 5-56 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHF 
                 CHNH(C═O)C2H5 
               
               
                 5-57 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHF 
                 CHNH(C═O)CH2CF3 
               
               
                 5-58 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHF 
                 CHNH(C═O)Pr-c 
               
               
                 5-59 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHF 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-60 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHF 
                 CHNH(C═O)NHC2H5 
               
               
                 5-61 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHF 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-62 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHCl 
                 CHNH2 
               
               
                 5-63 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHCl 
                 CHNH(C═O)C2H5 
               
               
                 5-64 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHCl 
                 CHNH(C═O)CH2CF3 
               
               
                 5-65 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHCl 
                 CHNH(C═O)Pr-c 
               
               
                 5-66 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHCl 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-67 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHCl 
                 CHNH(C═O)NHC2H5 
               
               
                 5-68 
                 3,4,5-Cl3 
                 O 
                 H 
                 — 
                 CH2 
                 CHCl 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-69 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCl 
                 CHNH2 
               
               
                 5-70 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCl 
                 CHNH(C═O)C2H5 
               
               
                 5-71 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCl 
                 CHNH(C═O)CH2CF3 
               
               
                 5-72 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCl 
                 CHNH(C═O)Pr-c 
               
               
                 5-73 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCl 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-74 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCl 
                 CHNH(C═O)NHC2H5 
               
               
                 5-75 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCl 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-76 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCF3 
                 CHNH2 
               
               
                 5-77 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCF3 
                 CHNH(C═O)C2H5 
               
               
                 5-78 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCF3 
                 CHNH(C═O)CH2CF3 
               
               
                 5-79 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCF3 
                 CHNH(C═O)Pr-c 
               
               
                 5-80 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCF3 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-81 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCF3 
                 CHNH(C═O)NHC2H5 
               
               
                 5-82 
                 3,5-Cl2 
                 O 
                 H 
                 — 
                 CH2 
                 CHCF3 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-83 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHSCH3 
                 CHNH2 
               
               
                 5-84 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHSCH3 
                 CHNH(C═O)C2H5 
               
               
                 5-85 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHSCH3 
                 CHNH(C═O)CH2CF3 
               
               
                 5-86 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHSCH3 
                 CHNH(C═O)Pr-c 
               
               
                 5-87 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHSCH3 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-88 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHSCH3 
                 CHNH(C═O)NHC2H5 
               
               
                 5-89 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHSCH3 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-90 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CHS(═O)CH3 
                 CHNH2 
               
               
                 5-91 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CHS(═O)CH3 
                 CHNH(C═O)C2H5 
               
               
                 5-92 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CHS(═O)CH3 
                 CHNH(C═O)CH2CF3 
               
               
                 5-93 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CHS(═O)CH3 
                 CHNH(C═O)Pr-c 
               
               
                 5-94 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CHS(═O)CH3 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-95 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CHS(═O)CH3 
                 CHNH(C═O)NHC2H5 
               
               
                 5-96 
                 3,5-(CF3)2 
                 O 
                 H 
                 — 
                 CH2 
                 CHS(═O)CH3 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-97 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CHS(═O)2CH3 
                 CHNH2 
               
               
                 5-98 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CHS(═O)2CH3 
                 CHNH(C═O)C2H5 
               
               
                 5-99 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CHS(═O)2CH3 
                 CHNH(C═O)CH2CF3 
               
               
                 5-100 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CHS(═O)2CH3 
                 CHNH(C═O)Pr-c 
               
               
                 5-101 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CHS(═O)2CH3 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-102 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CHS(═O)2CH3 
                 CHNH(C═O)NHC2H5 
               
               
                 5-103 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 — 
                 CH2 
                 CHS(═O)2CH3 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-104 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCN 
                 CHNH2 
               
               
                 5-105 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCN 
                 CHNH(C═O)C2H5 
               
               
                 5-106 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCN 
                 CHNH(C═O)CH2CF3 
               
               
                 5-107 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCN 
                 CHNH(C═O)Pr-c 
               
               
                 5-108 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCN 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-109 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCN 
                 CHNH(C═O)NHC2H5 
               
               
                 5-110 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 — 
                 CH2 
                 CHCN 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-111 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH2 
               
               
                 5-112 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH3 
               
               
                 5-113 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)C2H5 
               
               
                 5-114 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2CF3 
               
               
                 5-115 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)Pr-c 
               
               
                 5-116 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)Pr-i 
               
               
                 5-117 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2Pr-e 
               
               
                 5-118 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2SMe 
               
               
                 5-119 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2S(═O)Me 
               
               
                 5-120 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-121 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CF3 
               
               
                 5-122 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)NHCH3 
               
               
                 5-123 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)NHC2H5 
               
               
                 5-124 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)NHCH2CCH 
               
               
                 5-125 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═S)C2H5 
               
               
                 5-126 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═S)NHCH3 
               
               
                 5-127 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)OCH3 
               
               
                 5-128 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-129 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHN((C═O)Pr-i)2 
               
               
                 5-130 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH2 
               
               
                 5-131 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)C2H5 
               
               
                 5-132 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2CF3 
               
               
                 5-133 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)Pr-c 
               
               
                 5-134 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-135 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)NHC2H5 
               
               
                 5-136 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-137 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH2 
               
               
                 5-138 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)C2H5 
               
               
                 5-139 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2CF3 
               
               
                 5-140 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)Pr-c 
               
               
                 5-141 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-142 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)NHC2H5 
               
               
                 5-143 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-144 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNH2 
               
               
                 5-145 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)C2H5 
               
               
                 5-146 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)CH2CF3 
               
               
                 5-147 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)Pr-c 
               
               
                 5-148 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-149 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)NHC2H5 
               
               
                 5-150 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-151 
                 3,4-Cl, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNH2 
               
               
                 5-152 
                 3,4-Cl, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)C2H5 
               
               
                 5-153 
                 3,4-Cl, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)CH2CF3 
               
               
                 5-154 
                 3,4-Cl, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)Pr-c 
               
               
                 5-155 
                 3,4-Cl, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-156 
                 3,4-Cl, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)NHC2H5 
               
               
                 5-157 
                 3,4-Cl, 5-CF3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-158 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CHNH2 
               
               
                 5-159 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CHNH(C═O)C2H5 
               
               
                 5-160 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CHNH(C═O)CH2CF3 
               
               
                 5-161 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CHNH(C═O)Pr-c 
               
               
                 5-162 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-163 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CHNH(C═O)NHC2H5 
               
               
                 5-164 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-165 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CHNH2 
               
               
                 5-166 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CHNH(C═O)C2H5 
               
               
                 5-167 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CHNH(C═O)CH2CF3 
               
               
                 5-168 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CHNH(C═O)Pr-c 
               
               
                 5-169 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-170 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CHNH(C═O)NHC2H5 
               
               
                 5-171 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-172 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CHNH2 
               
               
                 5-173 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CHNH(C═O)C2H5 
               
               
                 5-174 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CHNH(C═O)CH2CF3 
               
               
                 5-175 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CHNH(C═O)Pr-c 
               
               
                 5-176 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-177 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CHNH(C═O)NHC2H5 
               
               
                 5-178 
                 3,4,5-Cl3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-179 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CHNH2 
               
               
                 5-180 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CHNH(C═O)C2H5 
               
               
                 5-181 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CHNH(C═O)CH2CF3 
               
               
                 5-182 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CHNH(C═O)Pr-c 
               
               
                 5-183 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-184 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CHNH(C═O)NHC2H5 
               
               
                 5-185 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-186 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCF3 
                 CHNH2 
               
               
                 5-187 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCF3 
                 CHNH(C═O)C2H5 
               
               
                 5-188 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCF3 
                 CHNH(C═O)CH2CF3 
               
               
                 5-189 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCF3 
                 CHNH(C═O)Pr-c 
               
               
                 5-190 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCF3 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-191 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCF3 
                 CHNH(C═O)NHC2H5 
               
               
                 5-192 
                 3,5-Cl2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHCF3 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-193 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHSCH3 
                 CHNH2 
               
               
                 5-194 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHSCH3 
                 CHNH(C═O)C2H5 
               
               
                 5-195 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHSCH3 
                 CHNH(C═O)CH2CF3 
               
               
                 5-196 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHSCH3 
                 CHNH(C═O)Pr-c 
               
               
                 5-197 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHSCH3 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-198 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHSCH3 
                 CHNH(C═O)NHC2H5 
               
               
                 5-199 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHSCH3 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-200 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHS(═O)CH3 
                 CHNH2 
               
               
                 5-201 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHS(═O)CH3 
                 CHNH(C═O)C2H5 
               
               
                 5-202 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHS(═O)CH3 
                 CHNH(C═O)CH2CF3 
               
               
                 5-203 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHS(═O)CH3 
                 CHNH(C═O)Pr-c 
               
               
                 5-204 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHS(═O)CH3 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-205 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHS(═O)CH3 
                 CHNH(C═O)NHC2H5 
               
               
                 5-206 
                 3,5-(CF3)2 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHS(═O)CH3 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-207 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHS(═O)2CH3 
                 CHNH2 
               
               
                 5-208 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHS(═O)2CH3 
                 CHNH(C═O)C2H5 
               
               
                 5-209 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHS(═O)2CH3 
                 CHNH(C═O)CH2CF3 
               
               
                 5-210 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHS(═O)2CH3 
                 CHNH(C═O)Pr-c 
               
               
                 5-211 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHS(═O)2CH3  
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-212 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHS(═O)2CH3 
                 CHNH(C═O)NHC2H5 
               
               
                 5-213 
                 3,4-Cl2, 5-CF3 
                 O 
                 H 
                 CH2 
                 CH2 
                 CHS(═O)2CH3 
                 CHNH(C═O)OC4H9-tert 
               
               
                 5-214 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCN 
                 CHNH2 
               
               
                 5-215 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCN 
                 CHNH(C═O)C2H5 
               
               
                 5-216 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCN 
                 CHNH(C═O)CH2CF3 
               
               
                 5-217 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCN 
                 CHNH(C═O)Pr-c 
               
               
                 5-218 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCN 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 5-219 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCN 
                 CHNH(C═O)NHC2H5 
               
               
                 5-220 
                 3,4,5-Cl3 
                 CH2 
                 H 
                 CH2 
                 CH2 
                 CHCN 
                 CHNH(C═O)OC4H9-tert 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 6 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Example 
                 W 1   
                 W 2   
                 W 3   
                 W 4   
               
               
                   
               
               
                 6-1 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 6-2 
                 — 
                 CH2 
                 O 
                 CH2 
               
               
                 6-3 
                 — 
                 CH2 
                 CH2 
                 O 
               
               
                 6-4 
                 — 
                 O 
                 CH2 
                 O 
               
               
                 6-5 
                 — 
                 O 
                 CF2 
                 O 
               
               
                 6-6 
                 — 
                 CH 
                 CH 
                 O 
               
               
                 6-7 
                 — 
                 CH2 
                 CH2 
                 S 
               
               
                 6-8 
                 — 
                 CH2 
                 S 
                 CH2 
               
               
                 6-9 
                 — 
                 CH 
                 CH 
                 S 
               
               
                 6-10 
                 — 
                 CH2 
                 CH2 
                 NH 
               
               
                 6-11 
                 — 
                 CH2 
                 NH 
                 CH2 
               
               
                 6-12 
                 — 
                 NH 
                 CH2 
                 CH2 
               
               
                 6-13 
                 — 
                 CH 
                 CH 
                 NH 
               
               
                 6-14 
                 — 
                 CH 
                 N 
                 NH 
               
               
                 6-15 
                 — 
                 C═O 
                 O 
                 CH2 
               
               
                 6-16 
                 — 
                 CH2 
                 S 
                 C═O 
               
               
                 6-17 
                 — 
                 N 
                 CH 
                 O 
               
               
                 6-18 
                 — 
                 N 
                 CH 
                 S 
               
               
                 6-19 
                 — 
                 N 
                 CH 
                 NH 
               
               
                 6-20 
                 — 
                 O 
                 CH 
                 N 
               
               
                 6-21 
                 — 
                 S 
                 CH 
                 N 
               
               
                 6-22 
                 — 
                 CH 
                 N 
                 O 
               
               
                 6-23 
                 — 
                 CH 
                 N 
                 S 
               
               
                 6-24 
                 — 
                 CH2 
                 CH2 
                 C═O 
               
               
                 6-25 
                 — 
                 CH 
                 CH 
                 C═O 
               
               
                 6-26 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 6-27 
                 — 
                 C═O 
                 CH2 
                 CH2 
               
               
                 6-28 
                 — 
                 CH2 
                 C═O 
                 NH 
               
               
                 6-29 
                 — 
                 NH 
                 C═O 
                 CH2 
               
               
                 6-30 
                 — 
                 CH2 
                 C═O 
                 N(C═O)CH3 
               
               
                 6-31 
                 — 
                 CH2 
                 C═O 
                 N(C═O)CH2CF3 
               
               
                 6-32 
                 — 
                 CH2 
                 CH2 
                 N(C═O)CH3 
               
               
                 6-33 
                 — 
                 CH2 
                 CH2 
                 N(C═O)C2H5 
               
               
                 6-34 
                 — 
                 CH2 
                 CH2 
                 N(C═O)CH2CF3 
               
               
                 6-35 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 6-36 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 6-37 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 6-38 
                 — 
                 CH2 
                 N(C═O)CH3 
                 CH2 
               
               
                 6-39 
                 — 
                 CH2 
                 N(C═O)C2H5 
                 CH2 
               
               
                 6-40 
                 — 
                 CH2 
                 N(C═O)CH2CF3 
                 CH2 
               
               
                 6-41 
                 — 
                 CH2 
                 N(C═O)Pr-c 
                 CH2 
               
               
                 6-42 
                 — 
                 CH2 
                 N(C═O)NCH3 
                 CH2 
               
               
                 6-43 
                 — 
                 CH2 
                 N(C═O)NC2H5 
                 CH2 
               
               
                 6-44 
                 — 
                 CH2 
                 N(C═O)NCH2CCH 
                 CH2 
               
               
                 6-45 
                 — 
                 CH2 
                 O 
                 C═NH 
               
               
                 6-46 
                 — 
                 CH2 
                 S 
                 C═NH 
               
               
                 6-47 
                 — 
                 CH2 
                 N 
                 C═NH 
               
               
                 6-48 
                 — 
                 CH 
                 CH 
                 N(C═O)CH3 
               
               
                 6-49 
                 — 
                 CH 
                 CH 
                 N(C═O)C2H5 
               
               
                 6-50 
                 — 
                 CH 
                 CH 
                 N(C═O)NC2H5 
               
               
                 6-51 
                 — 
                 CH 
                 CH 
                 N(C═O)NCH2CCH 
               
               
                 6-52 
                 — 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 6-53 
                 — 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 6-54 
                 — 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 6-55 
                 — 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 6-56 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 6-57 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 6-58 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 6-59 
                 — 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 6-60 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 6-61 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2SMe 
               
               
                 6-62 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)Me 
               
               
                 6-63 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 6-64 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH3 
               
               
                 6-65 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 6-66 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH2CCH 
               
               
                 6-67 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
               
               
                 6-68 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 6-69 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 6-70 
                 — 
                 CH2 
                 CH2 
                 CHOC(═O)CH3 
               
               
                 6-71 
                 — 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 6-72 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═S)NHC2H5 
               
               
                 6-73 
                 — 
                 CH2 
                 CH2 
                 CHNHCSC2H5 
               
               
                 6-74 
                 — 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 6-75 
                 — 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 6-76 
                 — 
                 CH2 
                 CHNHCO2C4H9-tert 
                 CH2 
               
               
                 6-77 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 6-78 
                 — 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 6-79 
                 — 
                 O 
                 N 
                 CNH2 
               
               
                 6-80 
                 — 
                 O 
                 N 
                 CNHCO2C4H9-tert 
               
               
                 6-81 
                 — 
                 NCH3 
                 N 
                 CNH2 
               
               
                 6-82 
                 — 
                 NCH3 
                 N 
                 CNHCO2C4H9-tert 
               
               
                 6-83 
                 — 
                 SO2 
                 N 
                 CNH2 
               
               
                 6-84 
                 — 
                 SO2 
                 N 
                 CNHCO2C4H9-tert 
               
               
                 6-85 
                 — 
                 CH 
                 CH 
                 CHNH2 
               
               
                 6-86 
                 — 
                 CH 
                 CH 
                 CHNHCOCH3 
               
               
                 6-87 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)C2H5 
               
               
                 6-88 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH2CF3 
               
               
                 6-89 
                 — 
                 CH 
                 CH 
                 CHNHCOPr-c 
               
               
                 6-90 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH2SMe 
               
               
                 6-91 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH2S(═0OMe 
               
               
                 6-92 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 6-93 
                 — 
                 CH 
                 CH 
                 CHNHC(═O)NHC2H5 
               
               
                 6-94 
                 — 
                 CH 
                 CH 
                 CHNHCO2C4H9-tert 
               
               
                 6-95 
                 — 
                 CH 
                 CH 
                 CHOC(═O)CH3 
               
               
                 6-96 
                 — 
                 CH 
                 CH 
                 CHN3 
               
               
                 6-97 
                 — 
                 CH2 
                 CH2 
                 NNH2 
               
               
                 6-98 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH3 
               
               
                 6-99 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)C2H5 
               
               
                 6-100 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2CF3 
               
               
                 6-101 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)Pr-c 
               
               
                 6-102 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2SMe 
               
               
                 6-103 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2S(═O)Me 
               
               
                 6-104 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2S(═O)2Me 
               
               
                 6-105 
                 — 
                 CH2 
                 CH2 
                 NNHC(═O)NHC2H5 
               
               
                 6-106 
                 — 
                 CH2 
                 CH2 
                 NNHCO2Bu-t 
               
               
                 6-107 
                 — 
                 CH2 
                 CHCH3 
                 CHNHCO2C4H9-tert 
               
               
                 6-108 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNHCO2C4H9-tert 
               
               
                 6-109 
                 — 
                 CH2 
                 CHCl 
                 CHNHCO2C4H9-tert 
               
               
                 6-110 
                 — 
                 CH2 
                 CHF 
                 CHNHCO2C4H9-tert 
               
               
                 6-111 
                 CH2 
                 CH2 
                 O 
                 C═O 
               
               
                 6-112 
                 CH2 
                 CH2 
                 O 
                 CH2 
               
               
                 6-113 
                 CH2 
                 O 
                 CH2 
                 CH2 
               
               
                 6-114 
                 CH2 
                 CH2 
                 CH2 
                 O 
               
               
                 6-115 
                 CH2 
                 CH 
                 CH 
                 N 
               
               
                 6-116 
                 CH2 
                 CH 
                 N 
                 CH 
               
               
                 6-117 
                 CH2 
                 N 
                 CH 
                 CH 
               
               
                 6-118 
                 CH2 
                 CH 
                 CBr 
                 N 
               
               
                 6-119 
                 CH2 
                 CH 
                 CCl 
                 N 
               
               
                 6-120 
                 CH2 
                 CH 
                 CCN 
                 N 
               
               
                 6-121  
                 CH2 
                 CH2 
                 CH2 
                 NH 
               
               
                 6-122 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)CH3 
               
               
                 6-123 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 6-124 
                 CH2 
                 CH2 
                 NH 
                 CH2 
               
               
                 6-125 
                 CH2 
                 CH2 
                 N(C═O)CH3 
                 CH2 
               
               
                 6-126 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
                 CH2 
               
               
                 6-127 
                 CH2 
                 CH2 
                 C═O 
                 N 
               
               
                 6-128 
                 CH2 
                 C═O 
                 N 
                 CH2 
               
               
                 6-129 
                 CH2 
                 N 
                 C═O 
                 CH2 
               
               
                 6-130 
                 CH2 
                 NH 
                 NH 
                 C═O 
               
               
                 6-131 
                 CH2 
                 NCH3 
                 NCH3 
                 C═O 
               
               
                 6-132 
                 CH2 
                 NCH3 
                 NH 
                 C═O 
               
               
                 6-133 
                 CH 
                 N 
                 NH 
                 C═O 
               
               
                 6-134 
                 CH2 
                 O 
                 N 
                 C═O 
               
               
                 6-135 
                 CH2 
                 N 
                 O 
                 C═O 
               
               
                 6-136 
                 CH 
                 N 
                 O 
                 C═O 
               
               
                 6-137 
                 CH 
                 N 
                 CH 
                 N 
               
               
                 6-138 
                 CH 
                 N 
                 N(C═O)CH3 
                 C═O 
               
               
                 6-139 
                 CH 
                 N 
                 N(C═O)C2H5 
                 C═O 
               
               
                 6-140 
                 CH 
                 N 
                 N(C═O)Pr-c 
                 C═O 
               
               
                 6-141 
                 CH 
                 N 
                 N(C═O)CH2CF3 
                 C═O 
               
               
                 6-142 
                 CH 
                 N 
                 NC(═O)NHC2H5 
                 C═O 
               
               
                 6-143 
                 CH2 
                 O 
                 N(C═O)CH3 
                 C═O 
               
               
                 6-144 
                 CH2 
                 NCH3 
                 N(C═O)CH3 
                 C═O 
               
               
                 6-145 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)C2H5 
               
               
                 6-146 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)CH2CF3 
               
               
                 6-147 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 6-148 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 6-149 
                 CH2 
                 CH2 
                 N(C═O)CH3 
                 CH2 
               
               
                 6-150 
                 CH2 
                 CH2 
                 N(C═O)C2H5 
                 CH2 
               
               
                 6-151 
                 CH2 
                 CH2 
                 N(C═O)CH2CF3 
                 CH2 
               
               
                 6-152 
                 CH2 
                 CH2 
                 N(C═O)Pr-c 
                 CH2 
               
               
                 6-153 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
                 CH2 
               
               
                 6-154 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
                 CH2 
               
               
                 6-155 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
                 CH2 
               
               
                 6-156 
                 CH2 
                 CH2 
                 CH2 
                 C═O 
               
               
                 6-157 
                 CH2 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 6-158 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 6-159 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 6-160 
                 CH2 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 6-161 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 6-162 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 6-163 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 6-164 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 6-165 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 6-166 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2SMe 
               
               
                 6-167 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)Me 
               
               
                 6-168 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 6-169 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH3 
               
               
                 6-170 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 6-171 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH2CCH 
               
               
                 6-172 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
               
               
                 6-173 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 6-174 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 6-175 
                 CH2 
                 CH2 
                 CH2 
                 CHOC(═O)CH3 
               
               
                 6-176 
                 CH2 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 6-177 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═S)NHC2H5 
               
               
                 6-178 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCSC2H5 
               
               
                 6-179 
                 CH2 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 6-180 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 6-181 
                 CH2 
                 CH2  
                 CHNHCO2C4H9-tert 
                 CH2 
               
               
                 6-182 
                 CH2 
                 CH2 
                 C═O 
                 CH2 
               
               
                 6-183 
                 CH2 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 6-184 
                 CH 
                 CH 
                 CH 
                 CNH2 
               
               
                 6-185 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH3 
               
               
                 6-186 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 6-187 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 6-188 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 6-189 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2Pr-c 
               
               
                 6-190 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2SMe 
               
               
                 6-191 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 6-192 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 6-193 
                 CH 
                 CH 
                 CH 
                 CNHC(═O)NHCH3 
               
               
                 6-194 
                 CH 
                 CH 
                 CH 
                 CNHC(═O)NHC2H5 
               
               
                 6-195 
                 CH 
                 CH 
                 CH 
                 CNHC(═O)NHCH2CCH 
               
               
                 6-196 
                 CH 
                 CH 
                 CH 
                 CNHCO2C4H9-tert 
               
               
                 6-197 
                 CH 
                 CH 
                 CH 
                 CNHCO2CH3 
               
               
                 6-198 
                 CH 
                 CH 
                 CH 
                 CNHCO2Ph 
               
               
                 6-199 
                 CH 
                 CH 
                 CH 
                 CNC(═S)NHC2H5 
               
               
                 6-200 
                 CH 
                 CH 
                 CH 
                 CHNHCSC2H5 
               
               
                 6-201 
                 CH 
                 CH 
                 CNH2 
                 CH 
               
               
                 6-202 
                 CH 
                 CH 
                 CNH(C═O)CH3 
                 CH 
               
               
                 6-203 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
                 CH 
               
               
                 6-204 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
                 CH 
               
               
                 6-205 
                 CH 
                 CH 
                 CNHC(═O)NHC2H5 
                 CH 
               
               
                 6-206 
                 CH 
                 CH 
                 CNHCO2C4H9-tert 
                 CH 
               
               
                 6-207 
                 CH 
                 N 
                 N 
                 CCl 
               
               
                 6-208 
                 CH 
                 N 
                 N 
                 CNH2 
               
               
                 6-209 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH3 
               
               
                 6-210 
                 CH 
                 N 
                 N 
                 CNH(C═O)C2H5 
               
               
                 6-211 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 6-212 
                 CH 
                 N 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 6-213 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2Pr-c 
               
               
                 6-214 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2SMe 
               
               
                 6-215 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 6-216 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 6-217 
                 CH 
                 N 
                 N 
                 CNHC(═O)NHCH3 
               
               
                 6-218 
                 CH 
                 N 
                 N 
                 CNHC(═O)NHC2H5 
               
               
                 6-219 
                 CH 
                 N 
                 N 
                 CNHC(═O)NHCH2CCH 
               
               
                 6-220 
                 CH 
                 N 
                 N 
                 CNC(═S)NHC2H5 
               
               
                 6-221 
                 CH 
                 N 
                 N 
                 CNHC(═S)C2H5 
               
               
                 6-222 
                 CH 
                 CH 
                 N 
                 CNH2 
               
               
                 6-223 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH3 
               
               
                 6-224 
                 CH 
                 CH 
                 N 
                 CNH(C═O)C2H5 
               
               
                 6-225 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 6-226 
                 CH 
                 CH 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 6-227 
                 CH 
                 CH 
                 N 
                 CNHC(═O)NHC2H5 
               
               
                 6-228 
                 N 
                 CH 
                 CH 
                 CNH2 
               
               
                 6-229 
                 N 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 6-230 
                 N 
                 CH 
                 CH 
                 CNHC(═O)NHC2H5 
               
               
                 6-231 
                 CH 
                 N 
                 CH 
                 CNH2 
               
               
                 6-232 
                 CH 
                 N 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 6-233 
                 CH 
                 N 
                 CH 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 6-234 
                 N 
                 N 
                 CH 
                 CNH2 
               
               
                 6-235 
                 N 
                 N 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 6-236 
                 N 
                 N 
                 CH 
                 CNH(C═O)CH2SMe 
               
               
                 6-237 
                 N 
                 CH 
                 N 
                 CNH2 
               
               
                 6-238 
                 N 
                 CH 
                 N 
                 CNH(C═O)CH3 
               
               
                 6-239 
                 N 
                 CH 
                 N 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 6-240 
                 CH 
                 NCH3 
                 N 
                 CNH2 
               
               
                 6-241 
                 CH 
                 NCH3 
                 N 
                 CNH(C═O)C2H5 
               
               
                 6-242 
                 CH 
                 NCH3 
                 N 
                 CNHC(═O)NHC2H5 
               
               
                 6-243 
                 CH2 
                 O 
                 N 
                 CNH2 
               
               
                 6-244 
                 CH2 
                 O 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 6-245 
                 CH2 
                 O 
                 N 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 6-246 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH2 
               
               
                 6-247 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNHCOCH3 
               
               
                 6-248 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)C2H5 
               
               
                 6-249 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2CF3 
               
               
                 6-250 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNHCOPr-c 
               
               
                 6-251 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2Pr-c 
               
               
                 6-252 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2SMe 
               
               
                 6-253 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2S(═O)Me 
               
               
                 6-254 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 6-255 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNHC(═O)NHCH3 
               
               
                 6-256 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNHC(═O)NHC2H5 
               
               
                 6-257 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNHC(═O)NHCH2CCH 
               
               
                 6-258 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNHCO2C4H9-tert 
               
               
                 6-259 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNHCO2CH3 
               
               
                 6-260 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNHCO2Ph 
               
               
                 6-261 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNC(═S)NHC2 H5 
               
               
                 6-262 
                 CH2 
                 CH2 
                 CHCH3 
                 CHHNH(C═S)C2H5 
               
               
                 6-263 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNH2 
               
               
                 6-264 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNHCOCH3 
               
               
                 6-265 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNHC(═O)NHC2H5 
               
               
                 6-266 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CHNHCO2C4H9-tert 
               
               
                 6-267 
                 CH2 
                 CH2 
                 CHF 
                 CHNH2 
               
               
                 6-268 
                 CH2 
                 CH2 
                 CHF 
                 CHNHCOCH3 
               
               
                 6-269 
                 CH2 
                 CH2 
                 CHF 
                 CHNHC(═O)NHC2H5 
               
               
                 6-270 
                 CH2 
                 CH2 
                 CHF 
                 CHNHCO2C4H9-tert 
               
               
                 6-271 
                 CH2 
                 CH2 
                 CHCl 
                 CHNH2 
               
               
                 6-272 
                 CH2 
                 CH2 
                 CHCl 
                 CNH(C═O)CH3 
               
               
                 6-273 
                 CH2 
                 CH2 
                 CHCl 
                 CHNHC(═O)NHC2H5 
               
               
                 6-274 
                 CH2 
                 CH2 
                 CHCl 
                 CHNHCO2C4H9-tert 
               
               
                 6-275 
                 — 
                 CH 
                 CH 
                 NCO2C4H9-tert 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 6-1 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Example 
                 W 1   
                 W 2   
                 W 3   
                 W 4   
               
               
                   
               
               
                 6-1-1 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 6-1-2 
                 — 
                 CH2 
                 O 
                 CH2 
               
               
                 6-1-3 
                 — 
                 CH2 
                 CH2 
                 O 
               
               
                 6-1-4 
                 — 
                 O 
                 CH2 
                 O 
               
               
                 6-1-5 
                 — 
                 O 
                 CF2 
                 O 
               
               
                 6-1-6 
                 — 
                 CH 
                 CH 
                 O 
               
               
                 6-1-7 
                 — 
                 CH2 
                 CH2 
                 S 
               
               
                 6-1-8 
                 — 
                 CH2 
                 S 
                 CH2 
               
               
                 6-1-9 
                 — 
                 CH 
                 CH 
                 S 
               
               
                 6-1-10 
                 — 
                 CH2 
                 CH2 
                 NH 
               
               
                 6-1-11 
                 — 
                 CH2 
                 NH 
                 CH2 
               
               
                 6-1-12 
                 — 
                 NH 
                 CH2 
                 CH2 
               
               
                 6-1-13 
                 — 
                 CH 
                 CH 
                 NH 
               
               
                 6-1-14 
                 — 
                 CH 
                 N 
                 NH 
               
               
                 6-1-15 
                 — 
                 C═O 
                 O 
                 CH2 
               
               
                 6-1-16 
                 — 
                 CH2 
                 S 
                 C═O 
               
               
                 6-1-17 
                 — 
                 N 
                 CH 
                 O 
               
               
                 6-1-18 
                 — 
                 N 
                 CH 
                 S 
               
               
                 6-1-19 
                 — 
                 N 
                 CH 
                 NH 
               
               
                 6-1-20 
                 — 
                 O 
                 CH 
                 N 
               
               
                 6-1-21 
                 — 
                 S 
                 CH 
                 N 
               
               
                 6-1-22 
                 — 
                 CH 
                 N 
                 O 
               
               
                 6-1-23 
                 — 
                 CH 
                 N 
                 S 
               
               
                 6-1-24 
                 — 
                 CH2 
                 CH2 
                 C═O 
               
               
                 6-1-25 
                 — 
                 CH 
                 CH 
                 C═O 
               
               
                 6-1-26 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 6-1-27 
                 — 
                 C═O 
                 CH2 
                 CH2 
               
               
                 6-1-28 
                 — 
                 CH2 
                 C═O 
                 NH 
               
               
                 6-1-29 
                 — 
                 NH 
                 C═O 
                 CH2 
               
               
                 6-1-30 
                 — 
                 CH2 
                 C═O 
                 N(C═O)CH3 
               
               
                 6-1-31 
                 — 
                 CH2 
                 C═O 
                 N(C═O)CH2CF3 
               
               
                 6-1-32 
                 — 
                 CH2 
                 CH2 
                 N(C═O)CH3 
               
               
                 6-1-33 
                 — 
                 CH2 
                 CH2 
                 N(C═O)C2H5 
               
               
                 6-1-34 
                 — 
                 CH2 
                 CH2 
                 N(C═O)CH2CF3 
               
               
                 6-1-35 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 6-1-36 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 6-1-37 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 6-1-38 
                 — 
                 CH2 
                 N(C═O)CH3 
                 CH2 
               
               
                 6-1-39 
                 — 
                 CH2 
                 N(C═O)C2H5 
                 CH2 
               
               
                 6-1-40 
                 — 
                 CH2 
                 N(C═O)CH2CF3 
                 CH2 
               
               
                 6-1-41 
                 — 
                 CH2 
                 N(C═O)Pr-c 
                 CH2 
               
               
                 6-1-42 
                 — 
                 CH2 
                 N(C═O)NCH3 
                 CH2 
               
               
                 6-1-43 
                 — 
                 CH2 
                 N(C═O)NC2H5 
                 CH2 
               
               
                 6-1-44 
                 — 
                 CH2 
                 N(C═O)NCH2CCH 
                 CH2 
               
               
                 6-1-45 
                 — 
                 CH2 
                 O 
                 C═NH 
               
               
                 6-1-46 
                 — 
                 CH2 
                 S 
                 C═NH 
               
               
                 6-1-47 
                 — 
                 CH2 
                 N 
                 C═NH 
               
               
                 6-1-48 
                 — 
                 CH 
                 CH 
                 N(C═O)CH3 
               
               
                 6-1-49 
                 — 
                 CH 
                 CH 
                 N(C═O)C2H5 
               
               
                 6-1-50 
                 — 
                 CH 
                 CH 
                 N(C═O)NC2H5 
               
               
                 6-1-51 
                 — 
                 CH 
                 CH 
                 N(C═O)NCH2CCH 
               
               
                 6-1-52 
                 — 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 6-1-53 
                 — 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 6-1-54 
                 — 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 6-1-55 
                 — 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 6-1-56 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 6-1-57 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 6-1-58 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 6-1-59 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 6-1-60 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 6-1-61 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2SMe 
               
               
                 6-1-62 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═)OCH2S(═O)Me 
               
               
                 6-1-63 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 6-1-64 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH3 
               
               
                 6-1-65 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 6-1-66 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH2CCH 
               
               
                 6-1-67 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2Bu-t 
               
               
                 6-1-68 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 6-1-69 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 6-1-70 
                 — 
                 CH2 
                 CH2 
                 CHOC(═O)CH3 
               
               
                 6-1-71 
                 — 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 6-1-72 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═S)NHC2H5 
               
               
                 6-1-73 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)C2H5 
               
               
                 6-1-74 
                 — 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 6-1-75 
                 — 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 6-1-76 
                 — 
                 CH2 
                 CHNHCO2Bu-t 
                 CH2 
               
               
                 6-1-77 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 6-1-78 
                 — 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 6-1-79 
                 — 
                 O 
                 N 
                 CNH2 
               
               
                 6-1-80 
                 — 
                 O 
                 N 
                 CNHCO2Bu-t 
               
               
                 6-1-81 
                 — 
                 NCH3 
                 N 
                 CNH2 
               
               
                 6-1-82 
                 — 
                 NCH3 
                 N 
                 CNHCO2Bu-t 
               
               
                 6-1-83 
                 — 
                 SO2 
                 N 
                 CNH2 
               
               
                 6-1-84 
                 — 
                 SO2 
                 N 
                 CNHCO2Bu-t 
               
               
                 6-1-85 
                 — 
                 CH 
                 CH 
                 CHNH2 
               
               
                 6-1-86 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH3 
               
               
                 6-1-87 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)C2H5 
               
               
                 6-1-88 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH2CF3 
               
               
                 6-1-89 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)Pr-c 
               
               
                 6-1-90 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH2SMe 
               
               
                 6-1-91 
                 — 
                 CH 
                 CH 
                 CHNH(C═)OCH2S(═O)Me 
               
               
                 6-1-92 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 6-1-93 
                 — 
                 CH 
                 CH 
                 CHNHC(═O)NHC2H5 
               
               
                 6-1-94 
                 — 
                 CH 
                 CH 
                 CHNHCO2Bu-t 
               
               
                 6-1-95 
                 — 
                 CH 
                 CH 
                 CHOC(═O)CH3 
               
               
                 6-1-96 
                 — 
                 CH 
                 CH 
                 CHN3 
               
               
                 6-1-97 
                 — 
                 CH2 
                 CH2 
                 NNH2 
               
               
                 6-1-98 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH3 
               
               
                 6-1-99 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)C2H5 
               
               
                 6-1-100 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2CF3 
               
               
                 6-1-101 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)Pr-c 
               
               
                 6-1-102 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2SMe 
               
               
                 6-1-103 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2S(═O)Me 
               
               
                 6-1-104 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2S(═O)2Me 
               
               
                 6-1-105 
                 — 
                 CH2 
                 CH2 
                 NNHC(═O)NHC2H5 
               
               
                 6-1-106 
                 — 
                 CH2 
                 CH2 
                 NNHCO2Bu-t 
               
               
                 6-1-107 
                 — 
                 CH2 
                 CHCH3 
                 CHNHCO2Bu-t 
               
               
                 6-1-108 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNHCO2Bu-t 
               
               
                 6-1-109 
                 — 
                 CH2 
                 CHCl 
                 CHNHCO2Bu-t 
               
               
                 6-1-110 
                 — 
                 CH2 
                 CHF 
                 CHNHCO2Bu-t 
               
               
                 6-1-111 
                 CH2 
                 CH2 
                 O 
                 C═O 
               
               
                 6-1-112 
                 CH2 
                 CH2 
                 O 
                 CH2 
               
               
                 6-1-113 
                 CH2 
                 O 
                 CH2 
                 CH2 
               
               
                 6-1-114 
                 CH2 
                 CH2 
                 CH2 
                 O 
               
               
                 6-1-115 
                 CH2 
                 CH 
                 CH 
                 N 
               
               
                 6-1-116 
                 CH2 
                 CH 
                 N 
                 CH 
               
               
                 6-1-117 
                 CH2 
                 N 
                 CH 
                 CH 
               
               
                 6-1-118 
                 CH2 
                 CH 
                 CBr 
                 N 
               
               
                 6-1-119 
                 CH2 
                 CH 
                 CCl 
                 N 
               
               
                 6-1-120 
                 CH2 
                 CH 
                 CCN 
                 N 
               
               
                 6-1-121 
                 CH2 
                 CH2 
                 CH2 
                 NH 
               
               
                 6-1-122 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)CH3 
               
               
                 6-1-123 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 6-1-124 
                 CH2 
                 CH2 
                 NH 
                 CH2 
               
               
                 6-1-125 
                 CH2 
                 CH2 
                 N(C═O)CH3 
                 CH2 
               
               
                 6-1-126 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
                 CH2 
               
               
                 6-1-127 
                 CH2 
                 CH2 
                 C═O 
                 N 
               
               
                 6-1-128 
                 CH2 
                 C═O 
                 N 
                 CH2 
               
               
                 6-1-129 
                 CH2 
                 N 
                 C═O 
                 CH2 
               
               
                 6-1-130 
                 CH2 
                 NH 
                 NH 
                 C═O 
               
               
                 6-1-131 
                 CH2 
                 NCH3 
                 NCH3 
                 C═O 
               
               
                 6-1-132 
                 CH2 
                 NCH3 
                 NH 
                 C═O 
               
               
                 6-1-133 
                 CH 
                 N 
                 NH 
                 C═O 
               
               
                 6-1-134 
                 CH2 
                 O 
                 N 
                 C═O 
               
               
                 6-1-135 
                 CH2 
                 N 
                 O 
                 C═O 
               
               
                 6-1-136 
                 CH 
                 N 
                 O 
                 C═O 
               
               
                 6-1-137 
                 CH 
                 N 
                 CH 
                 N 
               
               
                 6-1-138 
                 CH 
                 N 
                 N(C═O)CH3 
                 C═O 
               
               
                 6-1-139 
                 CH 
                 N 
                 N(C═O)C2H5 
                 C═O 
               
               
                 6-1-140 
                 CH 
                 N 
                 N(C═O)Pr-c 
                 C═O 
               
               
                 6-1-141 
                 CH 
                 N 
                 N(C═O)CH2CF3 
                 C═O 
               
               
                 6-1-142 
                 CH 
                 N 
                 NC(═O)NHC2H5 
                 C═O 
               
               
                 6-1-143 
                 CH2 
                 O 
                 N(C═O)CH3 
                 C═O 
               
               
                 6-1-144 
                 CH2 
                 NCH3 
                 N(C═O)CH3 
                 C═O 
               
               
                 6-1-145 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)C2H5 
               
               
                 6-1-146 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)CH2CF3 
               
               
                 6-1-147 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 6-1-148 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 6-1-149 
                 CH2 
                 CH2 
                 N(C═O)CH3 
                 CH2 
               
               
                 6-1-150 
                 CH2 
                 CH2 
                 N(C═O)C2H5 
                 CH2 
               
               
                 6-1-151 
                 CH2 
                 CH2 
                 N(C═O)CH2CF3 
                 CH2 
               
               
                 6-1-152 
                 CH2 
                 CH2 
                 N(C═O)Pr-c 
                 CH2 
               
               
                 6-1-153 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
                 CH2 
               
               
                 6-1-154 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
                 CH2 
               
               
                 6-1-155 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
                 CH2 
               
               
                 6-1-156 
                 CH2 
                 CH2 
                 CH2 
                 C═O 
               
               
                 6-1-157 
                 CH2 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 6-1-158 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 6-1-159 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 6-1-160 
                 CH2 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 6-1-161 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 6-1-162 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 6-1-163 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 6-1-164 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 6-1-165 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 6-1-166 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2SMe 
               
               
                 6-1-167 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═)OCH2S(═O)Me 
               
               
                 6-1-168 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 6-1-169 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH3 
               
               
                 6-1-170 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 6-1-171 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH2CCH 
               
               
                 6-1-172 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2Bu-t 
               
               
                 6-1-173 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 6-1-174 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 6-1-175 
                 CH2 
                 CH2 
                 CH2 
                 CHOC(═O)CH3 
               
               
                 6-1-176 
                 CH2 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 6-1-177 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═S)NHC2H5 
               
               
                 6-1-178 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)C2H5 
               
               
                 6-1-179 
                 CH2 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 6-1-180 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 6-1-181 
                 CH2 
                 CH2 
                 CHNHCO2Bu-t 
                 CH2 
               
               
                 6-1-182 
                 CH2 
                 CH2 
                 C═O 
                 CH2 
               
               
                 6-1-183 
                 CH2 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 6-1-184 
                 CH 
                 CH 
                 CH 
                 CNH2 
               
               
                 6-1-185 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH3 
               
               
                 6-1-186 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 6-1-187 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 6-1-188 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 6-1-189 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2Pr-c 
               
               
                 6-1-190 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2SMe 
               
               
                 6-1-191 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 6-1-192 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 6-1-193 
                 CH 
                 CH 
                 CH 
                 CNHC(═O)NHCH3 
               
               
                 6-1-194 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 6-1-195 
                 CH 
                 CH 
                 CH 
                 CNHC(═O)NHCH2CCH 
               
               
                 6-1-196 
                 CH 
                 CH 
                 CH 
                 CNHCO2Bu-t 
               
               
                 6-1-197 
                 CH 
                 CH 
                 CH 
                 CNHCO2CH3 
               
               
                 6-1-198 
                 CH 
                 CH 
                 CH 
                 CNHCO2Ph 
               
               
                 6-1-199 
                 CH 
                 CH 
                 CH 
                 CNC(═S)NHC2H5 
               
               
                 6-1-200 
                 CH 
                 CH 
                 CH 
                 CHNH(C═S)C2H5 
               
               
                 6-1-201 
                 CH 
                 CH 
                 CNH2 
                 CH 
               
               
                 6-1-202 
                 CH 
                 CH 
                 CNH(C═O)CH3 
                 CH 
               
               
                 6-1-203 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
                 CH 
               
               
                 6-1-204 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
                 CH 
               
               
                 6-1-205 
                 CH 
                 CH 
                 CNHC(═O)NHC2H5 
                 CH 
               
               
                 6-1-206 
                 CH 
                 N 
                 N 
                 CCI 
               
               
                 6-1-207 
                 CH 
                 N 
                 N 
                 CNH2 
               
               
                 6-1-208 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH3 
               
               
                 6-1-209 
                 CH 
                 N 
                 N 
                 CNH(C═O)C2H5 
               
               
                 6-1-210 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 6-1-211 
                 CH 
                 N 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 6-1-212 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2Pr-c 
               
               
                 6-1-213 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2SMe 
               
               
                 6-1-214 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2S(═0)Me 
               
               
                 6-1-215 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 6-1-216 
                 CH 
                 N 
                 N 
                 CNHC(═O)NHCH3 
               
               
                 6-1-217 
                 CH 
                 N 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 6-1-218 
                 CH 
                 N 
                 N 
                 CNHC(═O)NHCH2CCH 
               
               
                 6-1-219 
                 CH 
                 N 
                 N 
                 CNC(═S)NHC2H5 
               
               
                 6-1-220 
                 CH 
                 N 
                 N 
                 CNHC(═S)C2H5 
               
               
                 6-1-221 
                 CH 
                 CH 
                 N 
                 CNH2 
               
               
                 6-1-222 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH3 
               
               
                 6-1-223 
                 CH 
                 CH 
                 N 
                 CNH(C═O)C2H5 
               
               
                 6-1-224 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 6-1-225 
                 CH 
                 CH 
                 N 
                 CNH(C═0)Pr-c 
               
               
                 6-1-226 
                 CH 
                 CH 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 6-1-227 
                 N 
                 CH 
                 CH 
                 CNH2 
               
               
                 6-1-228 
                 N 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 6-1-229 
                 N 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 6-1-230 
                 CH 
                 N 
                 CH 
                 CNH2 
               
               
                 6-1-231 
                 CH 
                 N 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 6-1-232 
                 CH 
                 N 
                 CH 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 6-1-233 
                 N 
                 N 
                 CH 
                 CNH2 
               
               
                 6-1-234 
                 N 
                 N 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 6-1-235 
                 N 
                 N 
                 CH 
                 CNH(C═O)CH2SMe 
               
               
                 6-1-236 
                 N 
                 CH 
                 N 
                 CNH2 
               
               
                 6-1-237 
                 N 
                 CH 
                 N 
                 CNH(C═O)CH3 
               
               
                 6-1-238 
                 N 
                 CH 
                 N 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 6-1-239 
                 CH 
                 NCH3 
                 N 
                 CNH2 
               
               
                 6-1-240 
                 CH 
                 NCH3 
                 N 
                 CNH(C═O)C2H5 
               
               
                 6-1-241 
                 CH 
                 NCH3 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 6-1-242 
                 CH2 
                 O 
                 N 
                 CNH2 
               
               
                 6-1-243 
                 CH2 
                 O 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 6-1-244 
                 CH2 
                 O 
                 N 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 6-1-245 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH2 
               
               
                 6-1-246 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)CH3 
               
               
                 6-1-247 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)C2H5 
               
               
                 6-1-248 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)CH2CF3 
               
               
                 6-1-249 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)Pr-c 
               
               
                 6-1-250 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)CH2Pr-c 
               
               
                 6-1-251 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)CH2SMe 
               
               
                 6-1-252 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 6-1-253 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 6-1-254 
                 CH2 
                 CH2 
                 CHCH3 
                 CNHC(═O)NHCH3 
               
               
                 6-1-255 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)NHC2H5 
               
               
                 6-1-256 
                 CH2 
                 CH2 
                 CHCH3 
                 CNHC(═O)NHCH2CCH 
               
               
                 6-1-257 
                 CH2 
                 CH2 
                 CHCH3 
                 CNHCO2Bu-t 
               
               
                 6-1-258 
                 CH2 
                 CH2 
                 CHCH3 
                 CNHCO2CH3 
               
               
                 6-1-259 
                 CH2 
                 CH2 
                 CHCH3 
                 CNHCO2Ph 
               
               
                 6-1-260 
                 CH2 
                 CH2 
                 CHCH3 
                 CNC(═S)NHC2H5 
               
               
                 6-1-261 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═S)C2H5 
               
               
                 6-1-262 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CNH2 
               
               
                 6-1-263 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CNH(C═O)CH3 
               
               
                 6-1-264 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CNH(C═O)NHC2H5 
               
               
                 6-1-265 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CNHCO2Bu-t 
               
               
                 6-1-266 
                 CH2 
                 CH2 
                 CHF 
                 CNH2 
               
               
                 6-1-267 
                 CH2 
                 CH2 
                 CHF 
                 CNH(C═O)CH3 
               
               
                 6-1-268 
                 CH2 
                 CH2 
                 CHF 
                 CNH(C═O)NHC2H5 
               
               
                 6-1-269 
                 CH2 
                 CH2 
                 CHF 
                 CNHCO2Bu-t 
               
               
                 6-1-270 
                 CH2 
                 CH2 
                 CHCl 
                 CNH2 
               
               
                 6-1-271 
                 CH2 
                 CH2 
                 CHCl 
                 CNH(C═O)CH3 
               
               
                 6-1-272 
                 CH2 
                 CH2 
                 CHCl 
                 CNH(C═O)NHC2H5 
               
               
                 6-1-273 
                 CH2 
                 CH2 
                 CHCl 
                 CNHCO2Bu-t 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 6-2 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                 Example 
                 W 1   
                 W 2   
                 W 3   
                 W 4   
               
               
                   
               
               
                 6-2-1 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 6-2-2 
                 — 
                 CH2 
                 O 
                 CH2 
               
               
                 6-2-3 
                 — 
                 CH2 
                 CH2 
                 O 
               
               
                 6-2-4 
                 — 
                 O 
                 CH2 
                 O 
               
               
                 6-2-5 
                 — 
                 O 
                 CF2 
                 O 
               
               
                 6-2-6 
                 — 
                 CH 
                 CH 
                 O 
               
               
                 6-2-7 
                 — 
                 CH2 
                 CH2 
                 S 
               
               
                 6-2-8 
                 — 
                 CH2 
                 S 
                 CH2 
               
               
                 6-2-9 
                 — 
                 CH 
                 CH 
                 S 
               
               
                 6-2-10 
                 — 
                 CH2 
                 CH2 
                 NH 
               
               
                 6-2-11 
                 — 
                 CH2 
                 NH 
                 CH2 
               
               
                 6-2-12 
                 — 
                 NH 
                 CH2 
                 CH2 
               
               
                 6-2-13 
                 — 
                 CH 
                 CH 
                 NH 
               
               
                 6-2-14 
                 — 
                 CH 
                 N 
                 NH 
               
               
                 6-2-15 
                 — 
                 C═O 
                 O 
                 CH2 
               
               
                 6-2-16 
                 — 
                 CH2 
                 S 
                 C═O 
               
               
                 6-2-17 
                 — 
                 N 
                 CH 
                 O 
               
               
                 6-2-18 
                 — 
                 N 
                 CII 
                 S 
               
               
                 6-2-19 
                 — 
                 N 
                 CH 
                 NH 
               
               
                 6-2-20 
                 — 
                 O 
                 CH 
                 N 
               
               
                 6-2-21 
                 — 
                 S 
                 CH 
                 N 
               
               
                 6-2-22 
                 — 
                 CH 
                 N 
                 O 
               
               
                 6-2-23 
                 — 
                 CH 
                 N 
                 S 
               
               
                 6-2-24 
                 — 
                 CH2 
                 CH2 
                 C═O 
               
               
                 6-2-25 
                 — 
                 CH 
                 CH 
                 C═O 
               
               
                 6-2-26 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 6-2-27 
                 — 
                 C═O 
                 CH2 
                 CH2 
               
               
                 6-2-28 
                 — 
                 CH2 
                 C═O 
                 NH 
               
               
                 6-2-29 
                 — 
                 NH 
                 C═O 
                 CH2 
               
               
                 6-2-30 
                 — 
                 CH2 
                 C═O 
                 N(C═O)CH3 
               
               
                 6-2-31 
                 — 
                 CH2 
                 C═O 
                 N(C═O)CH2CF3 
               
               
                 6-2-32 
                 — 
                 CH2 
                 CH2 
                 N(C═O)CH3 
               
               
                 6-2-33 
                 — 
                 CH2 
                 CH2 
                 N(C═O)C2H5 
               
               
                 6-2-34 
                 — 
                 CH2 
                 CH2 
                 N(C═O)CH2CF3 
               
               
                 6-2-35 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 6-2-36 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 6-2-37 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 6-2-38 
                 — 
                 CH2 
                 N(C═O)CH3 
                 CH2 
               
               
                 6-2-39 
                 — 
                 CH2 
                 N(C═O)C2H5 
                 CH2 
               
               
                 6-2-40 
                 — 
                 CH2 
                 N(C═O)CH2CF3 
                 CH2 
               
               
                 6-2-41 
                 — 
                 CH2 
                 N(C═O)Pr-c 
                 CH2 
               
               
                 6-2-42 
                 — 
                 CH2 
                 N(C═O)NCH3 
                 CH2 
               
               
                 6-2-43 
                 — 
                 CH2 
                 N(C═O)NC2H5 
                 CH2 
               
               
                 6-2-44 
                 — 
                 CH2 
                 N(C═O)NCH2CCH 
                 CH2 
               
               
                 6-2-45 
                 — 
                 CH2 
                 O 
                 C═NH 
               
               
                 6-2-46 
                 — 
                 CH2 
                 S 
                 C═NH 
               
               
                 6-2-47 
                 — 
                 CH2 
                 N 
                 C═NH 
               
               
                 6-2-48 
                 — 
                 CH 
                 CH 
                 N(C═O)CH3 
               
               
                 6-2-49 
                 — 
                 CH 
                 CH 
                 N(C═O)C2H5 
               
               
                 6-2-50 
                 — 
                 CH 
                 CH 
                 N(C═O)NC2H5 
               
               
                 6-2-51 
                 — 
                 CH 
                 CH 
                 N(C═O)NCH2CCH 
               
               
                 6-2-52 
                 — 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 6-2-53 
                 — 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 6-2-54 
                 — 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 6-2-55 
                 — 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 6-2-56 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 6-2-57 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 6-2-58 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 6-2-59 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 6-2-60 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 6-2-61 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2SMe 
               
               
                 6-2-62 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═)OCH2S(═O)Me 
               
               
                 6-2-63 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 6-2-64 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH3 
               
               
                 6-2-65 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 6-2-66 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH2CCH 
               
               
                 6-2-67 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2Bu-t 
               
               
                 6-2-68 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 6-2-69 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 6-2-70 
                 — 
                 CH2 
                 CH2 
                 CHOC(═O)CH3 
               
               
                 6-2-71 
                 — 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 6-2-72 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═S)NHC2H5 
               
               
                 6-2-73 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)C2H5 
               
               
                 6-2-74 
                 — 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 6-2-75 
                 — 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 6-2-76 
                 — 
                 CH2 
                 CHNHCO2Bu-t 
                 CH2 
               
               
                 6-2-77 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 6-2-78 
                 — 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 6-2-79 
                 — 
                 O 
                 N 
                 CNH2 
               
               
                 6-2-80 
                 — 
                 O 
                 N 
                 CNHCO2Bu-t 
               
               
                 6-2-81 
                 — 
                 NCH3 
                 N 
                 CNH2 
               
               
                 6-2-82 
                 — 
                 NCH3 
                 N 
                 CNHCO2Bu-t 
               
               
                 6-2-83 
                 — 
                 SO2 
                 N 
                 CNH2 
               
               
                 6-2-84 
                 — 
                 SO2 
                 N 
                 CNHCO2Bu-t 
               
               
                 6-2-85 
                 — 
                 CH 
                 CH 
                 CHNH2 
               
               
                 6-2-86 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH3 
               
               
                 6-2-87 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)C2H5 
               
               
                 6-2-88 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH2CF3 
               
               
                 6-2-89 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)Pr-c 
               
               
                 6-2-90 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH2SMe 
               
               
                 6-2-91 
                 — 
                 CH 
                 CH 
                 CHNH(C═)OCH2S(═O)Me 
               
               
                 6-2-92 
                 — 
                 CH 
                 CH 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 6-2-93 
                 — 
                 CH 
                 CH 
                 CHNHC(═O)NHC2H5 
               
               
                 6-2-94 
                 — 
                 CH 
                 CH 
                 CHNHCO2Bu-t 
               
               
                 6-2-95 
                 — 
                 CH 
                 CH 
                 CHOC(═O)CH3 
               
               
                 6-2-96 
                 — 
                 CH 
                 CH 
                 CHN3 
               
               
                 6-2-97 
                 — 
                 CH2 
                 CH2 
                 NNH2 
               
               
                 6-2-98 
                 — 
                 CH2 
                 CH2 
                 NM-I(C═O)CH3 
               
               
                 6-2-99 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)C2H5 
               
               
                 6-2-100 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2CF3 
               
               
                 6-2-101 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)Pr-c 
               
               
                 6-2-102 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2SMe 
               
               
                 6-2-103 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2S(═O)Me 
               
               
                 6-2-104 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2S(═O)2Me 
               
               
                 6-2-105 
                 — 
                 CH2 
                 CH2 
                 NNHC(═O)NHC2H5 
               
               
                 6-2-106 
                 — 
                 CH2 
                 CH2 
                 NNHCO2Bu-t 
               
               
                 6-2-107 
                 — 
                 CH2 
                 CHCH3 
                 CHNHCO2Bu-t 
               
               
                 6-2-108 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNHCO2Bu-t 
               
               
                 6-2-109 
                 — 
                 CH2 
                 CHCl 
                 CHNHCO2Bu-t 
               
               
                 6-2-110 
                 — 
                 CH2 
                 CHF 
                 CHNHCO2Bu-t 
               
               
                 6-2-111 
                 CH2 
                 CH2 
                 O 
                 C═O 
               
               
                 6-2-112 
                 CH2 
                 CH2 
                 O 
                 CH2 
               
               
                 6-2-113 
                 CH2 
                 O 
                 CH2 
                 CH2 
               
               
                 6-2-114 
                 CH2 
                 CH2 
                 CH2 
                 O 
               
               
                 6-2-115 
                 CH2 
                 CH 
                 CH 
                 N 
               
               
                 6-2-116 
                 CH2 
                 CH 
                 N 
                 CH 
               
               
                 6-2-117 
                 CH2 
                 N 
                 CH 
                 CH 
               
               
                 6-2-118 
                 CH2 
                 CH 
                 CBr 
                 N 
               
               
                 6-2-119 
                 CH2 
                 CH 
                 CCl 
                 N 
               
               
                 6-2-120 
                 CH2 
                 CH 
                 CCN 
                 N 
               
               
                 6-2-121 
                 CH2 
                 CH2 
                 CH2 
                 NH 
               
               
                 6-2-122 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)CH3 
               
               
                 6-2-123 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 6-2-124 
                 CH2 
                 CH2 
                 NH 
                 CH2 
               
               
                 6-2-125 
                 CH2 
                 CH2 
                 N(C═O)CH3 
                 CH2 
               
               
                 6-2-126 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
                 CH2 
               
               
                 6-2-127 
                 CH2 
                 CH2 
                 C═O 
                 N 
               
               
                 6-2-128 
                 CH2 
                 C═O 
                 N 
                 CH2 
               
               
                 6-2-129 
                 CH2 
                 N 
                 C═O 
                 CH2 
               
               
                 6-2-130 
                 CH2 
                 NH 
                 NH 
                 C═O 
               
               
                 6-2-131 
                 CH2 
                 NCH3 
                 NCH3 
                 C═O 
               
               
                 6-2-132 
                 CH2 
                 NCH3 
                 NH 
                 C═O 
               
               
                 6-2-133 
                 CH 
                 N 
                 NH 
                 C═O 
               
               
                 6-2-134 
                 CH2 
                 O 
                 N 
                 C═O 
               
               
                 6-2-135 
                 CH2 
                 N 
                 O 
                 C═O 
               
               
                 6-2-136 
                 CH 
                 N 
                 O 
                 C═O 
               
               
                 6-2-137 
                 CH 
                 N 
                 CH 
                 N 
               
               
                 6-2-138 
                 CH 
                 N 
                 N(C═O)CH3 
                 C═O 
               
               
                 6-2-139 
                 CH 
                 N 
                 N(C═O)C2H5 
                 C═O 
               
               
                 6-2-140 
                 CH 
                 N 
                 N(C═O)Pr-c 
                 C═O 
               
               
                 6-2-141 
                 CH 
                 N 
                 N(C═O)CH2CF3 
                 C═O 
               
               
                 6-2-142 
                 CH 
                 N 
                 NC(═O)NHC2H5 
                 C═O 
               
               
                 6-2-143 
                 CH2 
                 O 
                 N(C═O)CH3 
                 C═O 
               
               
                 6-2-144 
                 CH2 
                 NCH3 
                 N(C═O)CH3 
                 C═O 
               
               
                 6-2-145 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)C2H5 
               
               
                 6-2-146 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)CH2CF3 
               
               
                 6-2-147 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 6-2-148 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 6-2-149 
                 CH2 
                 CH2 
                 N(C═O)CH3 
                 CH2 
               
               
                 6-2-150 
                 CH2 
                 CH2 
                 N(C═O)C2H5 
                 CH2 
               
               
                 6-2-151 
                 CH2 
                 CH2 
                 N(C═O)CH2CF3 
                 CH2 
               
               
                 6-2-152 
                 CH2 
                 CH2 
                 N(C═O)Pr-c 
                 CH2 
               
               
                 6-2-153 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
                 CH2 
               
               
                 6-2-154 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
                 CH2 
               
               
                 6-2-155 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
                 CH2 
               
               
                 6-2-156 
                 CH2 
                 CH2 
                 CH2 
                 C═O 
               
               
                 6-2-157 
                 CH2 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 6-2-158 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 6-2-159 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 6-2-160 
                 CH2 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 6-2-161 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 6-2-162 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 6-2-163 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 6-2-164 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 6-2-165 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 6-2-166 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2SMe 
               
               
                 6-2-167 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═)OCH2S(═O)Me 
               
               
                 6-2-168 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 6-2-169 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH3 
               
               
                 6-2-170 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 6-2-171 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH2CCH 
               
               
                 6-2-172 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2Bu-t 
               
               
                 6-2-173 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 6-2-174 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 6-2-175 
                 CH2 
                 CH2 
                 CH2 
                 CHOC(═O)CH3 
               
               
                 6-2-176 
                 CH2 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 6-2-177 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═S)NHC2H5 
               
               
                 6-2-178 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)C2H5 
               
               
                 6-2-179 
                 CH2 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 6-2-180 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 6-2-181 
                 CH2 
                 CH2 
                 CHNHCO2Bu-t 
                 CH2 
               
               
                 6-2-182 
                 CH2 
                 CH2 
                 C═O 
                 CH2 
               
               
                 6-2-183 
                 CH2 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 6-2-184 
                 CH 
                 CH 
                 CH 
                 CNH2 
               
               
                 6-2-185 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH3 
               
               
                 6-2-186 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 6-2-187 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 6-2-188 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 6-2-189 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2Pr-c 
               
               
                 6-2-190 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2SMe 
               
               
                 6-2-191 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 6-2-192 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 6-2-193 
                 CH 
                 CH 
                 CH 
                 CNHC(═O)NHCH3 
               
               
                 6-2-194 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 6-2-195 
                 CH 
                 CH 
                 CH 
                 CNHC(═O)NHCH2CCH 
               
               
                 6-2-196 
                 CH 
                 CH 
                 CH 
                 CNHCO2Bu-t 
               
               
                 6-2-197 
                 CH 
                 CH 
                 CH 
                 CNHCO2CH3 
               
               
                 6-2-198 
                 CH 
                 CH 
                 CH 
                 CNHCO2Ph 
               
               
                 6-2-199 
                 CH 
                 CH 
                 CH 
                 CNC(═S)NHC2H5 
               
               
                 6-2-200 
                 CH 
                 CH 
                 CH 
                 CHNH(C═S)C2H5 
               
               
                 6-2-201 
                 CH 
                 CH 
                 CNH2 
                 CH 
               
               
                 6-2-202 
                 CH 
                 CH 
                 CNH(C═O)CH3 
                 CH 
               
               
                 6-2-203 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
                 CH 
               
               
                 6-2-204 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
                 CH 
               
               
                 6-2-205 
                 CH 
                 CH 
                 CNHC(═O)NHC2H5 
                 CH 
               
               
                 6-2-206 
                 CH 
                 N 
                 N 
                 CCl 
               
               
                 6-2-207 
                 CH 
                 N 
                 N 
                 CNH2 
               
               
                 6-2-208 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH3 
               
               
                 6-2-209 
                 CH 
                 N 
                 N 
                 CNH(C═O)C2H5 
               
               
                 6-2-210 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 6-2-211 
                 CH 
                 N 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 6-2-212 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2Pr-c 
               
               
                 6-2-213 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2 SMe 
               
               
                 6-2-214 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 6-2-215 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 6-2-216 
                 CH 
                 N 
                 N 
                 CNHC(═O)NHCH3 
               
               
                 6-2-217 
                 CH 
                 N 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 6-2-218 
                 CH 
                 N 
                 N 
                 CNHC(═O)NHCH2CCH 
               
               
                 6-2-219 
                 CH 
                 N 
                 N 
                 CNC(═S)NHC2H5 
               
               
                 6-2-220 
                 CH 
                 N 
                 N 
                 CNHC(═S)C2H5 
               
               
                 6-2-221 
                 CH 
                 CH 
                 N 
                 CNH2 
               
               
                 6-2-222 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH3 
               
               
                 6-2-223 
                 CH 
                 CH 
                 N 
                 CNH(C═O)C2H5 
               
               
                 6-2-224 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 6-2-225 
                 CH 
                 CH 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 6-2-226 
                 CH 
                 CH 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 6-2-227 
                 N 
                 CH 
                 CH 
                 CNH2 
               
               
                 6-2-228 
                 N 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 6-2-229 
                 N 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 6-2-230 
                 CH 
                 N 
                 CH 
                 CNH2 
               
               
                 6-2-231 
                 CH 
                 N 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 6-2-232 
                 CH 
                 N 
                 CH 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 6-2-233 
                 N 
                 N 
                 CH 
                 CNH2 
               
               
                 6-2-234 
                 N 
                 N 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 6-2-235 
                 N 
                 N 
                 CH 
                 CNH(C═O)CH2SMe 
               
               
                 6-2-236 
                 N 
                 CH 
                 N 
                 CNH2 
               
               
                 6-2-237 
                 N 
                 CH 
                 N 
                 CNH(C═O)CH3 
               
               
                 6-2-238 
                 N 
                 CH 
                 N 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 6-2-239 
                 CH 
                 NCH3 
                 N 
                 CNH2 
               
               
                 6-2-240 
                 CH 
                 NCH3 
                 N 
                 CNH(C═O)C2H5 
               
               
                 6-2-241 
                 CH 
                 NCH3 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 6-2-242 
                 CH2 
                 O 
                 N 
                 CNH2 
               
               
                 6-2-243 
                 CH2 
                 O 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 6-2-244 
                 CH2 
                 O 
                 N 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 6-2-245 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH2 
               
               
                 6-2-246 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)CH3 
               
               
                 6-2-247 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)C2H5 
               
               
                 6-2-248 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)CH2CF3 
               
               
                 6-2-249 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)Pr-c 
               
               
                 6-2-250 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)CH2Pr-c 
               
               
                 6-2-251 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)CH2SMe 
               
               
                 6-2-252 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 6-2-253 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 6-2-254 
                 CH2 
                 CH2 
                 CHCH3 
                 CNHC(═O)NHCH3 
               
               
                 6-2-255 
                 CH2 
                 CH2 
                 CHCH3 
                 CNH(C═O)NHC2H5 
               
               
                 6-2-256 
                 CH2 
                 CH2 
                 CHCH3 
                 CNHC(═O)NHCH2CCH 
               
               
                 6-2-257 
                 CH2 
                 CH2 
                 CHCH3 
                 CNHCO2Bu-t 
               
               
                 6-2-258 
                 CH2 
                 CH2 
                 CHCH3 
                 CNHCO2CH3 
               
               
                 6-2-259 
                 CH2 
                 CH2 
                 CHCH3 
                 CNHCO2Ph 
               
               
                 6-2-260 
                 CH2 
                 CH2 
                 CHCH3 
                 CNC(═S)NHC2H5 
               
               
                 6-2-261 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═S)C2H5 
               
               
                 6-2-262 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CNH2 
               
               
                 6-2-263 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CNH(C═O)CH3 
               
               
                 6-2-264 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CNH(C═O)NHC2H5 
               
               
                 6-2-265 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CNHCO2Bu-t 
               
               
                 6-2-266 
                 CH2 
                 CH2 
                 CHF 
                 CNH2 
               
               
                 6-2-267 
                 CH2 
                 CH2 
                 CHF 
                 CNH(C═O)CH3 
               
               
                 6-2-268 
                 CH2 
                 CH2 
                 CHF 
                 CNH(C═O)NHC2H5 
               
               
                 6-2-269 
                 CH2 
                 CH2 
                 CHF 
                 CNHCO2Bu-t 
               
               
                 6-2-270 
                 CH2 
                 CH2 
                 CHCl 
                 CNH2 
               
               
                 6-2-271 
                 CH2 
                 CH2 
                 CHCl 
                 CNH(C═O)CH3 
               
               
                 6-2-272 
                 CH2 
                 CH2 
                 CHCl 
                 CNH(C═O)NHC2H5 
               
               
                 6-2-273 
                 CH2 
                 CH2 
                 CHCl 
                 CNHCO2Bu-t 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 7 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Example 
                 R 4 ′ 
                 W 1   
                 W 2   
                 W 3   
                 W 4   
               
               
                   
               
               
                 7-1 
                 Me 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 7-2 
                 Me 
                 — 
                 CH2 
                 O 
                 CH2 
               
               
                 7-3 
                 Me 
                 — 
                 CH2 
                 CH2 
                 O 
               
               
                 7-4 
                 Me 
                 — 
                 O 
                 CH2 
                 O 
               
               
                 7-5 
                 Me 
                 — 
                 O 
                 CF2 
                 O 
               
               
                 7-6 
                 Me 
                 — 
                 CH 
                 CH 
                 O 
               
               
                 7-7 
                 Me 
                 — 
                 CH2 
                 CH2 
                 S 
               
               
                 7-8 
                 Me 
                 — 
                 CH2 
                 S 
                 CH2 
               
               
                 7-9 
                 Me 
                 — 
                 CH 
                 CH 
                 S 
               
               
                 7-10 
                 Me 
                 — 
                 CH2 
                 CH2 
                 NH 
               
               
                 7-11 
                 Me 
                 — 
                 CH2 
                 NH 
                 CH2 
               
               
                 7-12 
                 Me 
                 — 
                 NH 
                 CH2 
                 CH2 
               
               
                 7-13 
                 Me 
                 — 
                 CH 
                 CH 
                 NH 
               
               
                 7-14 
                 Me 
                 — 
                 CH 
                 N 
                 NH 
               
               
                 7-15 
                 Me 
                 — 
                 C═O 
                 O 
                 CH2 
               
               
                 7-16 
                 Me 
                 — 
                 CH2 
                 S 
                 C═O 
               
               
                 7-17 
                 Me 
                 — 
                 N 
                 CH 
                 O 
               
               
                 7-18 
                 Me 
                 — 
                 N 
                 CH 
                 S 
               
               
                 7-19 
                 Me 
                 — 
                 N 
                 CH 
                 NH 
               
               
                 7-20 
                 Me 
                 — 
                 O 
                 CH 
                 N 
               
               
                 7-21 
                 Me 
                 — 
                 S 
                 CH 
                 N 
               
               
                 7-22 
                 Me 
                 — 
                 CH 
                 N 
                 O 
               
               
                 7-23 
                 Me 
                 — 
                 CH 
                 N 
                 S 
               
               
                 7-24 
                 Me 
                 — 
                 CH2 
                 CH2 
                 C═O 
               
               
                 7-25 
                 Me 
                 — 
                 CH 
                 CH 
                 C═O 
               
               
                 7-26 
                 Me 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 7-27 
                 Me 
                 — 
                 C═O 
                 CH2 
                 CH2 
               
               
                 7-28 
                 Me 
                 — 
                 CH2 
                 C═O 
                 NH 
               
               
                 7-29 
                 Me 
                 — 
                 NH 
                 C═O 
                 CH2 
               
               
                 7-30 
                 Me 
                 — 
                 CH2 
                 C═O 
                 N(C═O)CH3 
               
               
                 7-31 
                 Me 
                 — 
                 CH2 
                 C═O 
                 N(C═O)CH2CF3 
               
               
                 7-32 
                 Me 
                 — 
                 CH2 
                 CH2 
                 N(C═O)CH3 
               
               
                 7-33 
                 Me 
                 — 
                 CH2 
                 CH2 
                 N(C═O)C2H5 
               
               
                 7-34 
                 Me 
                 — 
                 CH2 
                 CH2 
                 N(C═O)CH2CF3 
               
               
                 7-35 
                 Me 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 7-36 
                 Me 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 7-37 
                 Me 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 7-38 
                 Me 
                 — 
                 CH2 
                 N(C═O)CH3 
                 CH2 
               
               
                 7-39 
                 Me 
                 — 
                 CH2 
                 N(C═O)C2H5 
                 CH2 
               
               
                 7-40 
                 Me 
                 — 
                 CH2 
                 N(C═O)CH2CF3 
                 CH2 
               
               
                 7-41 
                 Me 
                 — 
                 CH2 
                 N(C═O)Pr-c 
                 CH2 
               
               
                 7-42 
                 Me 
                 — 
                 CH2 
                 N(C═O)NCH3 
                 CH2 
               
               
                 7-43 
                 Me 
                 — 
                 CH2 
                 N(C═O)NC2H5 
                 CH2 
               
               
                 7-44 
                 Me 
                 — 
                 CH2 
                 N(C═O)NCH2CCH 
                 CH2 
               
               
                 7-45 
                 Me 
                 — 
                 CH2 
                 O 
                 C═NH 
               
               
                 7-46 
                 Me 
                 — 
                 CH2 
                 S 
                 C═NH 
               
               
                 7-47 
                 Me 
                 — 
                 CH2 
                 N 
                 C═NH 
               
               
                 7-48 
                 Me 
                 — 
                 CH 
                 CH 
                 N(C═O)CH3 
               
               
                 7-49 
                 Me 
                 — 
                 CH 
                 CH 
                 N(C═O)C2H5 
               
               
                 7-50 
                 Me 
                 — 
                 CH 
                 CH 
                 N(C═O)NC2H5 
               
               
                 7-51 
                 Me 
                 — 
                 CH 
                 CH 
                 N(C═O)NCH2CCH 
               
               
                 7-52 
                 Me 
                 — 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 7-53 
                 Me 
                 — 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 7-54 
                 Me 
                 — 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 7-55 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 7-56 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 7-57 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 7-58 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 7-59 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 7-60 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 7-61 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2SMe 
               
               
                 7-62 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)Me 
               
               
                 7-63 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 7-64 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 7-65 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 7-66 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 7-67 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
               
               
                 7-68 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 7-69 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 7-70 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHO(C═O)CH3 
               
               
                 7-71 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 7-72 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHC2H5 
               
               
                 7-73 
                 Me 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)C2H5 
               
               
                 7-74 
                 Me 
                 — 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 7-75 
                 Me 
                 — 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 7-76 
                 Me 
                 — 
                 CH2 
                 CHNHCO2C4H9-tert 
                 CH2 
               
               
                 7-77 
                 Me 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 7-78 
                 Me 
                 — 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 7-79 
                 Me 
                 — 
                 O 
                 N 
                 CNH2 
               
               
                 7-80 
                 Me 
                 — 
                 O 
                 N 
                 CNHCO2C4H9-tert 
               
               
                 7-81 
                 Me 
                 — 
                 NCH3 
                 N 
                 CNH2 
               
               
                 7-82 
                 Me 
                 — 
                 NCH3 
                 N 
                 CNHCO2C4H9-tert 
               
               
                 7-83 
                 Me 
                 — 
                 SO2 
                 N 
                 CNH2 
               
               
                 7-84 
                 Me 
                 — 
                 SO2 
                 N 
                 CNHCO2C4H9-tert 
               
               
                 7-85 
                 Me 
                 — 
                 CH 
                 CH 
                 CNH2 
               
               
                 7-86 
                 Me 
                 — 
                 CH 
                 CH 
                 CNH(C═O)CH3 
               
               
                 7-87 
                 Me 
                 — 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 7-88 
                 Me 
                 — 
                 CH 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 7-89 
                 Me 
                 — 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 7-90 
                 Me 
                 — 
                 CH 
                 CH 
                 CNH(C═O)CH2SMe 
               
               
                 7-91 
                 Me 
                 — 
                 CH 
                 CH 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 7-92 
                 Me 
                 — 
                 CH 
                 CH 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 7-93 
                 Me 
                 — 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 7-94 
                 Me 
                 — 
                 CH 
                 CH 
                 CNHCO2C4H9-tert 
               
               
                 7-95 
                 Me 
                 — 
                 CH 
                 CH 
                 CO(C═O)CH3 
               
               
                 7-96 
                 Me 
                 — 
                 CH 
                 CH 
                 CHN3 
               
               
                 7-97 
                 Me 
                 — 
                 CH2 
                 CH2 
                 NNH2 
               
               
                 7-98 
                 Me 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH3 
               
               
                 7-99 
                 Me 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)C2H5 
               
               
                 7-100 
                 Me 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2CF3 
               
               
                 7-101 
                 Me 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)Pr-c 
               
               
                 7-102 
                 Me 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2SMe 
               
               
                 7-103 
                 Me 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2S(═O)Me 
               
               
                 7-104 
                 Me 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2S(═O)2Me 
               
               
                 7-105 
                 Me 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)NHC2H5 
               
               
                 7-106 
                 Me 
                 — 
                 CH2 
                 CH2 
                 NNHCO2Bu-t 
               
               
                 7-107 
                 Me 
                 — 
                 CH2 
                 CHCH3 
                 CHNHCO2C4H9-tert 
               
               
                 7-108 
                 Me 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNHCO2C4H9-tert 
               
               
                 7-109 
                 Me 
                 — 
                 CH2 
                 CHCl 
                 CHNHCO2C4H9-tert 
               
               
                 7-110 
                 Me 
                 — 
                 CH2 
                 CHF 
                 CHNHCO2C4H9-tert 
               
               
                 7-111 
                 Me 
                 CH2 
                 CH2 
                 O 
                 C═O 
               
               
                 7-112 
                 Me 
                 CH2 
                 CH2 
                 O 
                 CH2 
               
               
                 7-113 
                 Me 
                 CH2 
                 O 
                 CH2 
                 CH2 
               
               
                 7-114 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 O 
               
               
                 7-115 
                 Me 
                 CH2 
                 CH 
                 CH 
                 N 
               
               
                 7-116 
                 Me 
                 CH2 
                 CH 
                 N 
                 CH 
               
               
                 7-117 
                 Me 
                 CH2 
                 N 
                 CH 
                 CH 
               
               
                 7-118 
                 Me 
                 CH2 
                 CH 
                 CBr 
                 N 
               
               
                 7-119 
                 Me 
                 CH2 
                 CH 
                 CCl 
                 N 
               
               
                 7-120 
                 Me 
                 CH2 
                 CH 
                 CCN 
                 N 
               
               
                 7-121 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 NH 
               
               
                 7-122 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)CH3 
               
               
                 7-123 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 7-124 
                 Me 
                 CH2 
                 CH2 
                 NH 
                 CH2 
               
               
                 7-125 
                 Me 
                 CH2 
                 CH2 
                 N(C═O)CH3 
                 CH2 
               
               
                 7-126 
                 Me 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
                 CH2 
               
               
                 7-127 
                 Me 
                 CH2 
                 CH2 
                 C═O 
                 N 
               
               
                 7-128 
                 Me 
                 CH2 
                 C═O 
                 N 
                 CH2 
               
               
                 7-129 
                 Me 
                 CH2 
                 N 
                 C═O 
                 CH2 
               
               
                 7-130 
                 Me 
                 CH2 
                 NH 
                 NH 
                 C═O 
               
               
                 7-131 
                 Me 
                 CH2 
                 NCH3 
                 NCH3 
                 C═O 
               
               
                 7-132 
                 Me 
                 CH2 
                 NCH3 
                 NH 
                 C═O 
               
               
                 7-133 
                 Me 
                 CH 
                 N 
                 NH 
                 C═O 
               
               
                 7-134 
                 Me 
                 CH2 
                 O 
                 N 
                 C═O 
               
               
                 7-135 
                 Me 
                 CH2 
                 N 
                 O 
                 C═O 
               
               
                 7-136 
                 Me 
                 CH 
                 N 
                 O 
                 C═O 
               
               
                 7-137 
                 Me 
                 CH 
                 N 
                 CH 
                 N 
               
               
                 7-138 
                 Me 
                 CH 
                 N 
                 N(C═O)CH3 
                 C═O 
               
               
                 7-139 
                 Me 
                 CH 
                 N 
                 N(C═O)C2H5 
                 C═O 
               
               
                 7-140 
                 Me 
                 CH 
                 N 
                 N(C═O)Pr-c 
                 C═O 
               
               
                 7-141 
                 Me 
                 CH 
                 N 
                 N(C═O)CH2CF3 
                 C═O 
               
               
                 7-142 
                 Me 
                 CH 
                 N 
                 NC(═O)NHC2H5 
                 C═O 
               
               
                 7-143 
                 Me 
                 CH2 
                 O 
                 N(C═O)CH3 
                 C═O 
               
               
                 7-144 
                 Me 
                 CH2 
                 NCH3 
                 N(C═O)CH3 
                 C═O 
               
               
                 7-145 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)C2H5 
               
               
                 7-146 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)CH2CF3 
               
               
                 7-147 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 7-148 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 7-149 
                 Me 
                 CH2 
                 CH2 
                 N(C═O)CH3 
                 CH2 
               
               
                 7-150 
                 Me 
                 CH2 
                 CH2 
                 N(C═O)C2H5 
                 CH2 
               
               
                 7-151 
                 Me 
                 CH2 
                 CH2 
                 N(C═O)CH2CF3 
                 CH2 
               
               
                 7-152 
                 Me 
                 CH2 
                 CH2 
                 N(C═O)Pr-c 
                 CH2 
               
               
                 7-153 
                 Me 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
                 CH2 
               
               
                 7-154 
                 Me 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
                 CH2 
               
               
                 7-155 
                 Me 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
                 CH2 
               
               
                 7-156 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 C═O 
               
               
                 7-157 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 7-158 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 7-159 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 7-160 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 7-161 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 7-162 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 7-163 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 7-164 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 7-165 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 7-166 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2SMe 
               
               
                 7-167 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)Me 
               
               
                 7-168 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 7-169 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 7-170 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 7-171 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 7-172 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
               
               
                 7-173 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 7-174 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 7-175 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHO(C═O)CH3 
               
               
                 7-176 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 7-177 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHC2H5 
               
               
                 7-178 
                 Me 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)C2H5 
               
               
                 7-179 
                 Me 
                 CH2 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 7-180 
                 Me 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 7-181 
                 Me 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
                 CH2 
               
               
                 7-182 
                 Me 
                 CH2 
                 CH2 
                 C═O 
                 CH2 
               
               
                 7-183 
                 Me 
                 CH2 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 7-184 
                 Me 
                 CH 
                 CH 
                 CH 
                 CNH2 
               
               
                 7-185 
                 Me 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH3 
               
               
                 7-186 
                 Me 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 7-187 
                 Me 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 7-188 
                 Me 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 7-189 
                 Me 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2Pr-c 
               
               
                 7-190 
                 Me 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2SMe 
               
               
                 7-191 
                 Me 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 7-192 
                 Me 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 7-193 
                 Me 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHCH3 
               
               
                 7-194 
                 Me 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 7-195 
                 Me 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHCH2CCH 
               
               
                 7-196 
                 Me 
                 CH 
                 CH 
                 CH 
                 CNHCO2C4H9-tert 
               
               
                 7-197 
                 Me 
                 CH 
                 CH 
                 CH 
                 CNHCO2CH3 
               
               
                 7-198 
                 Me 
                 CH 
                 CH 
                 CH 
                 CNHCO2Ph 
               
               
                 7-199 
                 Me 
                 CH 
                 CH 
                 CH 
                 CHN(C═S)NHC2H5 
               
               
                 7-200 
                 Me 
                 CH 
                 CH 
                 CH 
                 CHNH(C═S)C2H5 
               
               
                 7-201 
                 Me 
                 CH 
                 CH 
                 CNH2 
                 CH 
               
               
                 7-202 
                 Me 
                 CH 
                 CH 
                 CNH(C═O)CH3 
                 CH 
               
               
                 7-203 
                 Me 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
                 CH 
               
               
                 7-204 
                 Me 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
                 CH 
               
               
                 7-205 
                 Me 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
                 CH 
               
               
                 7-206 
                 Me 
                 CH 
                 CH 
                 CNHCO2C4H9-tert 
                 CH 
               
               
                 7-207 
                 Me 
                 CH 
                 N 
                 N 
                 CCI 
               
               
                 7-208 
                 Me 
                 CH 
                 N 
                 N 
                 CNH2 
               
               
                 7-209 
                 Me 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH3 
               
               
                 7-210 
                 Me 
                 CH 
                 N 
                 N 
                 CNH(C═O)C2H5 
               
               
                 7-211 
                 Me 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 7-212 
                 Me 
                 CH 
                 N 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 7-213 
                 Me 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2Pr-c 
               
               
                 7-214 
                 Me 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2SMe 
               
               
                 7-215 
                 Me 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 7-216 
                 Me 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 7-217 
                 Me 
                 CH 
                 N 
                 N 
                 CNH(C═O)NHCH3 
               
               
                 7-218 
                 Me 
                 CH 
                 N 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 7-219 
                 Me 
                 CH 
                 N 
                 N 
                 CNH(C═O)NHCH2CCH 
               
               
                 7-220 
                 Me 
                 CH 
                 N 
                 N 
                 CHN(C═S)NHC2H5 
               
               
                 7-221 
                 Me 
                 CH 
                 N 
                 N 
                 CNH(C═S)C2H5 
               
               
                 7-222 
                 Me 
                 CH 
                 CH 
                 N 
                 CNH2 
               
               
                 7-223 
                 Me 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH3 
               
               
                 7-224 
                 Me 
                 CH 
                 CH 
                 N 
                 CNH(C═O)C2H5 
               
               
                 7-225 
                 Me 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 7-226 
                 Me 
                 CH 
                 CH 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 7-227 
                 Me 
                 CH 
                 CH 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 7-228 
                 Me 
                 N 
                 CH 
                 CH 
                 CNH2 
               
               
                 7-229 
                 Me 
                 N 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 7-230 
                 Me 
                 N 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 7-231 
                 Me 
                 CH 
                 N 
                 CH 
                 CNH2 
               
               
                 7-232 
                 Me 
                 CH 
                 N 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 7-233 
                 Me 
                 CH 
                 N 
                 CH 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 7-234 
                 Me 
                 N 
                 N 
                 CH 
                 CNH2 
               
               
                 7-235 
                 Me 
                 N 
                 N 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 7-236 
                 Me 
                 N 
                 N 
                 CH 
                 CNH(C═O)CH2SMe 
               
               
                 7-237 
                 Me 
                 N 
                 CH 
                 N 
                 CNH2 
               
               
                 7-238 
                 Me 
                 N 
                 CH 
                 N 
                 CNH(C═O)CH3 
               
               
                 7-239 
                 Me 
                 N 
                 CH 
                 N 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 7-240 
                 Me 
                 CH 
                 NCH3 
                 N 
                 CNH2 
               
               
                 7-241 
                 Me 
                 CH 
                 NCH3 
                 N 
                 CNH(C═O)C2H5 
               
               
                 7-242 
                 Me 
                 CH 
                 NCH3 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 7-243 
                 Me 
                 CH2 
                 O 
                 N 
                 CNH2 
               
               
                 7-244 
                 Me 
                 CH2 
                 O 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 7-245 
                 Me 
                 CH2 
                 O 
                 N 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 7-246 
                 Me 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH2 
               
               
                 7-247 
                 Me 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH3 
               
               
                 7-248 
                 Me 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)C2H5 
               
               
                 7-249 
                 Me 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2CF3 
               
               
                 7-250 
                 Me 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)Pr-c 
               
               
                 7-251 
                 Me 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2Pr-c 
               
               
                 7-252 
                 Me 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2SMe 
               
               
                 7-253 
                 Me 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2S(═O)Me 
               
               
                 7-254 
                 Me 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 7-255 
                 Me 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)NHCH3 
               
               
                 7-256 
                 Me 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)NHC2H5 
               
               
                 7-257 
                 Me 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)NHCH2CCH 
               
               
                 7-258 
                 Me 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNHCO2C4H9-tert 
               
               
                 7-259 
                 Me 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNHCO2CH3 
               
               
                 7-260 
                 Me 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNHCO2Ph 
               
               
                 7-261 
                 Me 
                 CH2 
                 CH2 
                 CHCH3 
                 CHN(C═S)NHC2H5 
               
               
                 7-262 
                 Me 
                 CH2 
                 CH2 
                 CHCH3 
                 CHHNH(C═S)C2H5 
               
               
                 7-263 
                 Me 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CNH2 
               
               
                 7-264 
                 Me 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CNH(C═O)CH3 
               
               
                 7-265 
                 Me 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CNH(C═O)NHC2H5 
               
               
                 7-266 
                 Me 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CNHCO2C4H9-tert 
               
               
                 7-267 
                 Me 
                 CH2 
                 CH2 
                 CHF 
                 CNH2 
               
               
                 7-268 
                 Me 
                 CH2 
                 CH2 
                 CHF 
                 CNH(C═O)CH3 
               
               
                 7-269 
                 Me 
                 CH2 
                 CH2 
                 CHF 
                 CNH(C═O)NHC2H5 
               
               
                 7-270 
                 Me 
                 CH2 
                 CH2 
                 CHF 
                 CNHCO2C4H9-tert 
               
               
                 7-271 
                 Me 
                 CH2 
                 CH2 
                 CHCl 
                 CNH2 
               
               
                 7-272 
                 Me 
                 CH2 
                 CH2 
                 CHCl 
                 CNH(C═O)CH3 
               
               
                 7-273 
                 Me 
                 CH2 
                 CH2 
                 CHCl 
                 CNH(C═O)NHC2H5 
               
               
                 7-274 
                 Me 
                 CH2 
                 CH2 
                 CHCl 
                 CNHCO2C4H9-tert 
               
               
                 7-275 
                 H 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 7-276 
                 H 
                 — 
                 CH2 
                 O 
                 CH2 
               
               
                 7-277 
                 H 
                 — 
                 CH2 
                 CH2 
                 O 
               
               
                 7-278 
                 H 
                 — 
                 O 
                 CH2 
                 O 
               
               
                 7-279 
                 H 
                 — 
                 O 
                 CF2 
                 O 
               
               
                 7-280 
                 H 
                 — 
                 CH 
                 CH 
                 O 
               
               
                 7-281 
                 H 
                 — 
                 CH2 
                 CH2 
                 S 
               
               
                 7-282 
                 H 
                 — 
                 CH2 
                 S 
                 CH2 
               
               
                 7-283 
                 H 
                 — 
                 CH 
                 CH 
                 S 
               
               
                 7-284 
                 H 
                 — 
                 CH2 
                 CH2 
                 NH 
               
               
                 7-285 
                 H 
                 — 
                 CH2 
                 NH 
                 CH2 
               
               
                 7-286 
                 H 
                 — 
                 NH 
                 CH2 
                 CH2 
               
               
                 7-287 
                 H 
                 — 
                 CH 
                 CH 
                 NH 
               
               
                 7-288 
                 H 
                 — 
                 CH 
                 N 
                 NH 
               
               
                 7-289 
                 H 
                 — 
                 C═O 
                 O 
                 CH2 
               
               
                 7-290 
                 H 
                 — 
                 CH2 
                 S 
                 C═O 
               
               
                 7-291 
                 H 
                 — 
                 N 
                 CH 
                 O 
               
               
                 7-292 
                 H 
                 — 
                 N 
                 CH 
                 S 
               
               
                 7-293 
                 H 
                 — 
                 N 
                 CH 
                 NH 
               
               
                 7-294 
                 H 
                 — 
                 O 
                 CH 
                 N 
               
               
                 7-295 
                 H 
                 — 
                 S 
                 CH 
                 N 
               
               
                 7-296 
                 H 
                 — 
                 CH 
                 N 
                 O 
               
               
                 7-297 
                 H 
                 — 
                 CH 
                 N 
                 S 
               
               
                 7-298 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═O 
               
               
                 7-299 
                 H 
                 — 
                 CH 
                 CH 
                 C═O 
               
               
                 7-300 
                 H 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 7-301 
                 H 
                 — 
                 C═O 
                 CH2 
                 CH2 
               
               
                 7-302 
                 H 
                 — 
                 CH2 
                 C═O 
                 NH 
               
               
                 7-303 
                 H 
                 — 
                 NH 
                 C═O 
                 CH2 
               
               
                 7-304 
                 H 
                 — 
                 CH2 
                 C═O 
                 N(C═O)CH3 
               
               
                 7-305 
                 H 
                 — 
                 CH2 
                 C═O 
                 N(C═O)CH2CF3 
               
               
                 7-306 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)CH3 
               
               
                 7-307 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)C2H5 
               
               
                 7-308 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)CH2CF3 
               
               
                 7-309 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 7-310 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 7-311 
                 H 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 7-312 
                 H 
                 — 
                 CH2 
                 N(C═O)CH3 
                 CH2 
               
               
                 7-313 
                 H 
                 — 
                 CH2 
                 N(C═O)C2H5 
                 CH2 
               
               
                 7-314 
                 H 
                 — 
                 CH2 
                 N(C═O)CH2CF3 
                 CH2 
               
               
                 7-315 
                 H 
                 — 
                 CH2 
                 N(C═O)Pr-c 
                 CH2 
               
               
                 7-316 
                 H 
                 — 
                 CH2 
                 N(C═O)NCH3 
                 CH2 
               
               
                 7-317 
                 H 
                 — 
                 CH2 
                 N(C═O)NC2H5 
                 CH2 
               
               
                 7-318 
                 H 
                 — 
                 CH2 
                 N(C═O)NCH2CCH 
                 CH2 
               
               
                 7-319 
                 H 
                 — 
                 CH2 
                 0 
                 C═NH 
               
               
                 7-320 
                 H 
                 — 
                 CH2 
                 S 
                 C═NH 
               
               
                 7-321 
                 H 
                 — 
                 CH2 
                 N 
                 C═NH 
               
               
                 7-322 
                 H 
                 — 
                 CH 
                 CH 
                 N(C═O)CH3 
               
               
                 7-323 
                 H 
                 — 
                 CH 
                 CH 
                 N(C═O)C2H5 
               
               
                 7-324 
                 H 
                 — 
                 CH 
                 CH 
                 N(C═O)NC2H5 
               
               
                 7-325 
                 H 
                 — 
                 CH 
                 CH 
                 N(C═O)NCH2CCH 
               
               
                 7-326 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 7-327 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 7-328 
                 H 
                 — 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 7-329 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 7-330 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 7-331 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)C2 H5 
               
               
                 7-332 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 7-333 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 7-334 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 7-335 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2SMe 
               
               
                 7-336 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)Me 
               
               
                 7-337 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 7-338 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 7-339 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 7-340 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 7-341 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
               
               
                 7-342 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 7-343 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 7-344 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHO(C═O)CH3 
               
               
                 7-345 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 7-346 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)NHC2H5 
               
               
                 7-347 
                 H 
                 — 
                 CH2 
                 CH2 
                 CHNH(C═S)C2H5 
               
               
                 7-348 
                 H 
                 — 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 7-349 
                 H 
                 — 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 7-350 
                 H 
                 — 
                 CH2 
                 CHNHCO2C4H9-tert 
                 CH2 
               
               
                 7-351 
                 H 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 7-352 
                 H 
                 — 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 7-353 
                 H 
                 — 
                 O 
                 N 
                 CNH2 
               
               
                 7-354 
                 H 
                 — 
                 O 
                 N 
                 CNHCO2C4H9-tert 
               
               
                 7-355 
                 H 
                 — 
                 NCH3 
                 N 
                 CNH2 
               
               
                 7-356 
                 H 
                 — 
                 NCH3 
                 N 
                 CNHCO2C4H9-tert 
               
               
                 7-357 
                 H 
                 — 
                 SO2 
                 N 
                 CNH2 
               
               
                 7-358 
                 H 
                 — 
                 SO2 
                 N 
                 CNHCO2C4H9-tert 
               
               
                 7-359 
                 H 
                 — 
                 CH 
                 CH 
                 CNH2 
               
               
                 7-360 
                 H 
                 — 
                 CH 
                 CH 
                 CNH(C═O)CH3 
               
               
                 7-361 
                 H 
                 — 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 7-362 
                 H 
                 — 
                 CH 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 7-363 
                 H 
                 — 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 7-364 
                 H 
                 — 
                 CH 
                 CH 
                 CNH(C═O)CH2SMe 
               
               
                 7-365 
                 H 
                 — 
                 CH 
                 CH 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 7-366 
                 H 
                 — 
                 CH 
                 CH 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 7-367 
                 H 
                 — 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 7-368 
                 H 
                 — 
                 CH 
                 CH 
                 CNHCO2C4H9-tert 
               
               
                 7-369 
                 H 
                 — 
                 CH 
                 CH 
                 CO(C═O)CH3 
               
               
                 7-370 
                 H 
                 — 
                 CH 
                 CH 
                 CHN3 
               
               
                 7-371 
                 H 
                 — 
                 CH2 
                 CH2 
                 NNH2 
               
               
                 7-372 
                 H 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH3 
               
               
                 7-373 
                 H 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)C2H5 
               
               
                 7-374 
                 H 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2CF3 
               
               
                 7-375 
                 H 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)Pr-c 
               
               
                 7-376 
                 H 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2SMe 
               
               
                 7-377 
                 H 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2S(═O)Me 
               
               
                 7-378 
                 H 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)CH2S(═O)2Me 
               
               
                 7-379 
                 H 
                 — 
                 CH2 
                 CH2 
                 NNH(C═O)NHC2H5 
               
               
                 7-380 
                 H 
                 — 
                 CH2 
                 CH2 
                 NNHCO2Bu-t 
               
               
                 7-381 
                 H 
                 — 
                 CH2 
                 CHCH3 
                 CHNHCO2C4H9-tert 
               
               
                 7-382 
                 H 
                 — 
                 CH2 
                 C(CH3)2 
                 CHNHCO2C4H9-tert 
               
               
                 7-383 
                 H 
                 — 
                 CH2 
                 CHCI 
                 CHNHCO2C4H9-tert 
               
               
                 7-384 
                 H 
                 — 
                 CH2 
                 CHF 
                 CHNHCO2C4H9-tert 
               
               
                 7-385 
                 H 
                 CH2 
                 CH2 
                 O 
                 C═O 
               
               
                 7-386 
                 H 
                 CH2 
                 CH2 
                 O 
                 CH2 
               
               
                 7-387 
                 H 
                 CH2 
                 O 
                 CH2 
                 CH2 
               
               
                 7-388 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 O 
               
               
                 7-389 
                 H 
                 CH2 
                 CH 
                 CH 
                 N 
               
               
                 7-390 
                 H 
                 CH2 
                 CH 
                 N 
                 CH 
               
               
                 7-391 
                 H 
                 CH2 
                 N 
                 CH 
                 CH 
               
               
                 7-392 
                 H 
                 CH2 
                 CH 
                 CBr 
                 N 
               
               
                 7-393 
                 H 
                 CH2 
                 CH 
                 CCl 
                 N 
               
               
                 7-394 
                 H 
                 CH2 
                 CH 
                 CCN 
                 N 
               
               
                 7-395 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 NH 
               
               
                 7-396 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)CH3 
               
               
                 7-397 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 7-398 
                 H 
                 CH2 
                 CH2 
                 NH 
                 CH2 
               
               
                 7-399 
                 H 
                 CH2 
                 CH2 
                 N(C═O)CH3 
                 CH2 
               
               
                 7-400 
                 H 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
                 CH2 
               
               
                 7-401 
                 H 
                 CH2 
                 CH2 
                 C═O 
                 N 
               
               
                 7-402 
                 H 
                 CH2 
                 C═O 
                 N 
                 CH2 
               
               
                 7-403 
                 H 
                 CH2 
                 N 
                 C═O 
                 CH2 
               
               
                 7-404 
                 H 
                 CH2 
                 NH 
                 NH 
                 C═O 
               
               
                 7-405 
                 H 
                 CH2 
                 NCH3 
                 NCH3 
                 C═O 
               
               
                 7-406 
                 H 
                 CH2 
                 NCH3 
                 NH 
                 C═O 
               
               
                 7-407 
                 H 
                 CH 
                 N 
                 NH 
                 C═O 
               
               
                 7-408 
                 H 
                 CH2 
                 O 
                 N 
                 C═O 
               
               
                 7-409 
                 H 
                 CH2 
                 N 
                 O 
                 C═O 
               
               
                 7-410 
                 H 
                 CH 
                 N 
                 O 
                 C═O 
               
               
                 7-411 
                 H 
                 CH 
                 N 
                 CH 
                 N 
               
               
                 7-412 
                 H 
                 CH 
                 N 
                 N(C═O)CH3 
                 C═O 
               
               
                 7-413 
                 H 
                 CH 
                 N 
                 N(C═O)C2H5 
                 C═O 
               
               
                 7-414 
                 H 
                 CH 
                 N 
                 N(C═O)Pr-c 
                 C═O 
               
               
                 7-415 
                 H 
                 CH 
                 N 
                 N(C═O)CH2CF3 
                 C═O 
               
               
                 7-416 
                 H 
                 CH 
                 N 
                 NC(═O)NHC2H5 
                 C═O 
               
               
                 7-417 
                 H 
                 CH2 
                 O 
                 N(C═O)CH3 
                 C═O 
               
               
                 7-418 
                 H 
                 CH2 
                 NCH3 
                 N(C═O)CH3 
                 C═O 
               
               
                 7-419 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)C2H5 
               
               
                 7-420 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)CH2CF3 
               
               
                 7-421 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 7-422 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 7-423 
                 H 
                 CH2 
                 CH2 
                 N(C═O)CH3 
                 CH2 
               
               
                 7-424 
                 H 
                 CH2 
                 CH2 
                 N(C═O)C2H5 
                 CH2 
               
               
                 7-425 
                 H 
                 CH2 
                 CH2 
                 N(C═O)CH2CF3 
                 CH2 
               
               
                 7-426 
                 H 
                 CH2 
                 CH2 
                 N(C═O)Pr-c 
                 CH2 
               
               
                 7-427 
                 H 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
                 CH2 
               
               
                 7-428 
                 H 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
                 CH2 
               
               
                 7-429 
                 H 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
                 CH2 
               
               
                 7-430 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 C═O 
               
               
                 7-431 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 7-432 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 7-433 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 7-434 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH2 
               
               
                 7-435 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH3 
               
               
                 7-436 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
               
               
                 7-437 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2CF3 
               
               
                 7-438 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)Pr-c 
               
               
                 7-439 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2Pr-c 
               
               
                 7-440 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2SMe 
               
               
                 7-441 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)Me 
               
               
                 7-442 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 7-443 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH3 
               
               
                 7-444 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHC2H5 
               
               
                 7-445 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═O)NHCH2CCH 
               
               
                 7-446 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
               
               
                 7-447 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 7-448 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 7-449 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHO(C═O)CH3 
               
               
                 7-450 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 7-451 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)NHC2H5 
               
               
                 7-452 
                 H 
                 CH2 
                 CH2 
                 CH2 
                 CHNH(C═S)C2H5 
               
               
                 7-453 
                 H 
                 CH2 
                 CH2 
                 CHNH2 
                 CH2 
               
               
                 7-454 
                 H 
                 CH2 
                 CH2 
                 CHNH(C═O)C2H5 
                 CH2 
               
               
                 7-455 
                 H 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-tert 
                 CH2 
               
               
                 7-456 
                 H 
                 CH2 
                 CH2 
                 C═O 
                 CH2 
               
               
                 7-457 
                 H 
                 CH2 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 7-458 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH2 
               
               
                 7-459 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH3 
               
               
                 7-460 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 7-461 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 7-462 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 7-463 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2Pr-c 
               
               
                 7-464 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2SMe 
               
               
                 7-465 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 7-466 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 7-467 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHCH3 
               
               
                 7-468 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 7-469 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═O)NHCH2CCH 
               
               
                 7-470 
                 H 
                 CH 
                 CH 
                 CH 
                 CNHCO2C4H9-tert 
               
               
                 7-471 
                 H 
                 CH 
                 CH 
                 CH 
                 CNHCO2CH3 
               
               
                 7-472 
                 H 
                 CH 
                 CH 
                 CH 
                 CNHCO2Ph 
               
               
                 7-473 
                 H 
                 CH 
                 CH 
                 CH 
                 CHN(C═S)NHC2H5 
               
               
                 7-474 
                 H 
                 CH 
                 CH 
                 CH 
                 CNH(C═S)C2H5 
               
               
                 7-475 
                 H 
                 CH 
                 CH 
                 CNH2 
                 CH 
               
               
                 7-476 
                 H 
                 CH 
                 CH 
                 CNH(C═O)CH3 
                 CH 
               
               
                 7-477 
                 H 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
                 CH 
               
               
                 7-478 
                 H 
                 CH 
                 CH 
                 CNH(C═O)Pr-c 
                 CH 
               
               
                 7-479 
                 H 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
                 CH 
               
               
                 7-480 
                 H 
                 CH 
                 CH 
                 CNHCO2C4H9-tert 
                 CH 
               
               
                 7-481 
                 H 
                 CH 
                 N 
                 N 
                 CCl 
               
               
                 7-482 
                 H 
                 CH 
                 N 
                 N 
                 CNH2 
               
               
                 7-483 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH3 
               
               
                 7-484 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)C2H5 
               
               
                 7-485 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 7-486 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 7-487 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2Pr-c 
               
               
                 7-488 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2SMe 
               
               
                 7-489 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 7-490 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 7-491 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)NHCH3 
               
               
                 7-492 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 7-493 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═O)NHCH2CCH 
               
               
                 7-494 
                 H 
                 CH 
                 N 
                 N 
                 CHN(C═S)NHC2H5 
               
               
                 7-495 
                 H 
                 CH 
                 N 
                 N 
                 CNH(C═S)C2H5 
               
               
                 7-496 
                 H 
                 CH 
                 CH 
                 N 
                 CNH2 
               
               
                 7-497 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH3 
               
               
                 7-498 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)C2H5 
               
               
                 7-499 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)CH2CF3 
               
               
                 7-500 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 7-501 
                 H 
                 CH 
                 CH 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 7-502 
                 H 
                 N 
                 CH 
                 CH 
                 CNH2 
               
               
                 7-503 
                 H 
                 N 
                 CH 
                 CH 
                 CNH(C═O)C2H5 
               
               
                 7-504 
                 H 
                 N 
                 CH 
                 CH 
                 CNH(C═O)NHC2H5 
               
               
                 7-505 
                 H 
                 CH 
                 N 
                 CH 
                 CNH2 
               
               
                 7-506 
                 H 
                 CH 
                 N 
                 CH 
                 CNH(C═O)Pr-c 
               
               
                 7-507 
                 H 
                 CH 
                 N 
                 CH 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 7-508 
                 H 
                 N 
                 N 
                 CH 
                 CNH2 
               
               
                 7-509 
                 H 
                 N 
                 N 
                 CH 
                 CNH(C═O)CH2CF3 
               
               
                 7-510 
                 H 
                 N 
                 N 
                 CH 
                 CNH(C═O)CH2SMe 
               
               
                 7-511 
                 H 
                 N 
                 CH 
                 N 
                 CNH2 
               
               
                 7-512 
                 H 
                 N 
                 CH 
                 N 
                 CNH(C═O)CH3 
               
               
                 7-513 
                 H 
                 N 
                 CH 
                 N 
                 CNH(C═O)CH2S(═O)Me 
               
               
                 7-514 
                 H 
                 CH 
                 NCH3 
                 N 
                 CNH2 
               
               
                 7-515 
                 H 
                 CH 
                 NCH3 
                 N 
                 CNH(C═O)C2H5 
               
               
                 7-516 
                 H 
                 CH 
                 NCH3 
                 N 
                 CNH(C═O)NHC2H5 
               
               
                 7-517 
                 H 
                 CH2 
                 O 
                 N 
                 CNH2 
               
               
                 7-518 
                 H 
                 CH2 
                 O 
                 N 
                 CNH(C═O)Pr-c 
               
               
                 7-519 
                 H 
                 CH2 
                 O 
                 N 
                 CNH(C═O)CH2S(═O)2Me 
               
               
                 7-520 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH2 
               
               
                 7-521 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH3 
               
               
                 7-522 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)C2H5 
               
               
                 7-523 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2CF3 
               
               
                 7-524 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)Pr-c 
               
               
                 7-525 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2Pr-c 
               
               
                 7-526 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2SMe 
               
               
                 7-527 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2S(═O)Me 
               
               
                 7-528 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)CH2S(═O)2Me 
               
               
                 7-529 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)NHCH3 
               
               
                 7-530 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)NHC2H5 
               
               
                 7-531 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═O)NHCH2CCH 
               
               
                 7-532 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNHCO2C4H9-tert 
               
               
                 7-533 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNHCO2CH3 
               
               
                 7-534 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNHCO2Ph 
               
               
                 7-535 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHN(C═S)NHC2H5 
               
               
                 7-536 
                 H 
                 CH2 
                 CH2 
                 CHCH3 
                 CHNH(C═S)C2H5 
               
               
                 7-537 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CNH2 
               
               
                 7-538 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CNH(C═O)CH3 
               
               
                 7-539 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CNH(C═O)NHC2H5 
               
               
                 7-540 
                 H 
                 CH2 
                 CH2 
                 C(CH3)2 
                 CNHCO2C4H9-tert 
               
               
                 7-541 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CNH2 
               
               
                 7-542 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CNH(C═O)CH3 
               
               
                 7-543 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CNH(C═O)NHC2H5 
               
               
                 7-544 
                 H 
                 CH2 
                 CH2 
                 CHF 
                 CNHCO2C4H9-tert 
               
               
                 7-545 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CNH2 
               
               
                 7-546 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CNH(C═O)CH3 
               
               
                 7-547 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CNH(C═O)NHC2H5 
               
               
                 7-548 
                 H 
                 CH2 
                 CH2 
                 CHCl 
                 CNHCO2C4H9-tert 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 8 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Example 
                 Xm 
                 W 1   
                 W 2   
                 W 3   
                 W 4   
               
               
                   
               
               
                 8-1 
                 3,5-Cl2 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 8-2 
                 3,5-Cl2 
                 — 
                 CH2 
                 O 
                 CH2 
               
               
                 8-3 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 O 
               
               
                 8-4 
                 3,5-Cl2 
                 — 
                 O 
                 CH2 
                 O 
               
               
                 8-5 
                 3,5-Cl2 
                 — 
                 O 
                 CF2 
                 O 
               
               
                 8-6 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 O 
               
               
                 8-7 
                 3,5-Cl2 
                 — 
                 C═O 
                 O 
                 CH2 
               
               
                 8-8 
                 3,5-Cl2 
                 — 
                 N 
                 CH 
                 O 
               
               
                 8-9 
                 3,5-Cl2 
                 — 
                 N 
                 CH 
                 S 
               
               
                 8-10 
                 3,5-Cl2 
                 — 
                 N 
                 CH 
                 NH 
               
               
                 8-11 
                 3,5-Cl2 
                 — 
                 O 
                 CH 
                 N 
               
               
                 8-12 
                 3,5-Cl2 
                 — 
                 S 
                 CH 
                 N 
               
               
                 8-13 
                 3,5-Cl2 
                 — 
                 CH 
                 N 
                 O 
               
               
                 8-14 
                 3,5-Cl2 
                 — 
                 CH 
                 N 
                 S 
               
               
                 8-15 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 C═O 
               
               
                 8-16 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 C═O 
               
               
                 8-17 
                 3,5-Cl2 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 8-18 
                 3,5-Cl2 
                 — 
                 C═O 
                 CH2 
                 CH2 
               
               
                 8-19 
                 3,5-Cl2 
                 — 
                 CH2 
                 C═O 
                 NCOCH3 
               
               
                 8-20 
                 3,5-Cl2 
                 — 
                 CH2 
                 C═O 
                 NCOCH2CF3 
               
               
                 8-21 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NCOCH3 
               
               
                 8-22 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NCOC2H5 
               
               
                 8-23 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NCOCH2CF3 
               
               
                 8-24 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 8-25 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 8-26 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 8-27 
                 3,5-Cl2 
                 — 
                 CH2 
                 NCOCH3 
                 CH2 
               
               
                 8-28 
                 3,5-Cl2 
                 — 
                 CH2 
                 NCOC2H5 
                 CH2 
               
               
                 8-29 
                 3,5-Cl2 
                 — 
                 CH2 
                 NCOCH2CF3 
                 CH2 
               
               
                 8-30 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 8-31 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 8-32 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 8-33 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 8-34 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
               
               
                 8-35 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2CF3 
               
               
                 8-36 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 8-37 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2Pr-c 
               
               
                 8-38 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2SMe 
               
               
                 8-39 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2SOMe 
               
               
                 8-40 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2SO2Me 
               
               
                 8-41 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH3 
               
               
                 8-42 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 8-43 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH2CCH 
               
               
                 8-44 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
               
               
                 8-45 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 8-46 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 8-47 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHOC(═O)CH3 
               
               
                 8-48 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 8-49 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═S)NHC2H5 
               
               
                 8-50 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCSC2H5 
               
               
                 8-51 
                 3,5-Cl2 
                 — 
                 CH2 
                 CHNHCOC2H5 
                 CH2 
               
               
                 8-52 
                 3,5-Cl2 
                 — 
                 CH2 
                 CHNHCO2C4H9-t 
                 CH2 
               
               
                 8-53 
                 3,5-Cl2 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 8-54 
                 3,5-Cl2 
                 — 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 8-55 
                 3,5-Cl2 
                 — 
                 O 
                 N 
                 CHNHCO2C4H9-t 
               
               
                 8-56 
                 3,5-Cl2 
                 — 
                 NCH3 
                 N 
                 CHNHCO2C4H9-t 
               
               
                 8-57 
                 3,5-Cl2 
                 — 
                 SO2 
                 N 
                 CHNHCO2C4H9-t 
               
               
                 8-58 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHCOCH3 
               
               
                 8-59 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHCOC2H5 
               
               
                 8-60 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHCOCH2CF3 
               
               
                 8-61 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHCOPr-c 
               
               
                 8-62 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHCOCH2SMe 
               
               
                 8-63 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHCOCH2SOMe 
               
               
                 8-64 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHCOCH2SO2Me 
               
               
                 8-65 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHC(═O)NHC2H5 
               
               
                 8-66 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHCO2C4H9-t 
               
               
                 8-67 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHOC(═O)CH3 
               
               
                 8-68 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHN3 
               
               
                 8-69 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH3 
               
               
                 8-70 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHCOC2H5 
               
               
                 8-71 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH2CF3 
               
               
                 8-72 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHCOPr-c 
               
               
                 8-73 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH2SMe 
               
               
                 8-74 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH2SOMe 
               
               
                 8-75 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH2SO2Me 
               
               
                 8-76 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHC(═O)NHC2H5 
               
               
                 8-77 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHCO2C4H9-t 
               
               
                 8-78 
                 3,5-Cl2 
                 — 
                 CH2 
                 CHCH3 
                 NNHCO2C4H9-t 
               
               
                 8-79 
                 3,5-Cl2 
                 — 
                 CH2 
                 C(CH3)2 
                 NNHCO2C4H9-t 
               
               
                 8-80 
                 3,5-Cl2 
                 — 
                 CH2 
                 CHCl 
                 NNHCO2C4H9-t 
               
               
                 8-81 
                 3,5-CL2 
                 — 
                 CH2 
                 CHF 
                 NNHCO2C4H9-t 
               
               
                 8-82 
                 3,4,5-CL3 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 8-83 
                 3,4,5-CL3 
                 — 
                 CH2 
                 O 
                 CH2 
               
               
                 8-84 
                 3,4,5-CL3 
                 — 
                 CH2 
                 CH2 
                 O 
               
               
                 8-85 
                 3,4,5-Cl3 
                 — 
                 O 
                 CH2 
                 O 
               
               
                 8-86 
                 3,4,5-Cl3 
                 — 
                 O 
                 CF2 
                 O 
               
               
                 8-87 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 O 
               
               
                 8-88 
                 3,4,5-Cl3 
                 — 
                 C═O 
                 O 
                 CH2 
               
               
                 8-89 
                 3,4,5-Cl3 
                 — 
                 N 
                 CH 
                 O 
               
               
                 8-90 
                 3,4,5-Cl3 
                 — 
                 N 
                 CH 
                 S 
               
               
                 8-91 
                 3,4,5-Cl3 
                 — 
                 N 
                 CH 
                 NH 
               
               
                 8-92 
                 3,4,5-Cl3 
                 — 
                 O 
                 CH 
                 N 
               
               
                 8-93 
                 3,4,5-Cl3 
                 — 
                 S 
                 CH 
                 N 
               
               
                 8-94 
                 3,4,5-Cl3 
                 — 
                 CH 
                 N 
                 O 
               
               
                 8-95 
                 3,4,5-Cl3 
                 — 
                 CH 
                 N 
                 S 
               
               
                 8-96 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 C═O 
               
               
                 8-97 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 C═O 
               
               
                 8-98 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 8-99 
                 3,4,5-Cl3 
                 — 
                 C═O 
                 CH2 
                 CH2 
               
               
                 8-100 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 C═O 
                 NCOCH3 
               
               
                 8-101 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 C═O 
                 NCOCH2CF3 
               
               
                 8-102 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NCOCH3 
               
               
                 8-103 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NCOC2H5 
               
               
                 8-104 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NCOCH2CF3 
               
               
                 8-105 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 8-106 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 8-107 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 8-108 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 NCOCH3 
                 CH2 
               
               
                 8-109 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 NCOC2H5 
                 CH2 
               
               
                 8-110 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 NCOCH2CF3 
                 CH2 
               
               
                 8-111 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 8-112 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 8-113 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 8-114 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 8-115 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
               
               
                 8-116 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2CF3 
               
               
                 8-117 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 8-118 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2Pr-c 
               
               
                 8-119 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2SMe 
               
               
                 8-120 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2SOMe 
               
               
                 8-121 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2SO2Me 
               
               
                 8-122 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH3 
               
               
                 8-123 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 8-124 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH2CCH 
               
               
                 8-125 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
               
               
                 8-126 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 8-127 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 8-128 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHOC(═O)CH3 
               
               
                 8-129 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 8-130 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═S)NHC2H5 
               
               
                 8-131 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCSC2H5 
               
               
                 8-132 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CHNHCOC2H5 
                 CH2 
               
               
                 8-133 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CHNHCO2C4H9-t 
                 CH2 
               
               
                 8-134 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 8-135 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 8-136 
                 3,4,5-Cl3 
                 — 
                 O 
                 N 
                 CHNHCO2C4H9-t 
               
               
                 8-137 
                 3,4,5-Cl3 
                 — 
                 NCH3 
                 N 
                 CHNHCO2C4H9-t 
               
               
                 8-138 
                 3,4,5-Cl3 
                 — 
                 SO2 
                 N 
                 CHNHCO2C4H9-t 
               
               
                 8-139 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHCOCH3 
               
               
                 8-140 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHCOC2H5 
               
               
                 8-141 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHCOCH2CF3 
               
               
                 8-142 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHCOPr-c 
               
               
                 8-143 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHCOCH2SMe 
               
               
                 8-144 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHCOCH2SOMe 
               
               
                 8-145 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHCOCH2SO2Me 
               
               
                 8-146 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHC(═O)NHC2H5 
               
               
                 8-147 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHCO2C4H9-t 
               
               
                 8-148 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHOC(═O)CH3 
               
               
                 8-149 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHN3 
               
               
                 8-150 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH3 
               
               
                 8-151 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHCOC2H5 
               
               
                 8-152 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH2CF3 
               
               
                 8-153 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHCOPr-c 
               
               
                 8-154 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH2SMe 
               
               
                 8-155 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH2SOMe 
               
               
                 8-156 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH2SO2Me 
               
               
                 8-157 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHC(═O)NHC2H5 
               
               
                 8-158 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHCO2C4H9-t 
               
               
                 8-159 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CHCH3 
                 NNHCO2C4H9-t 
               
               
                 8-160 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 C(CH3)2 
                 NNHCO2C4H9-t 
               
               
                 8-161 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CHCl 
                 NNHCO2C4H9-t 
               
               
                 8-162 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CHF 
                 NNHCO2C4H9-t 
               
               
                 8-163 
                 3,5-(CF3)2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 8-164 
                 3,5-(CF3)2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
               
               
                 8-165 
                 3,5-(CF3)2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2CF3 
               
               
                 8-166 
                 3,5-(CF3)2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 8-167 
                 3,5-(CF3)2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2SO2Me 
               
               
                 8-168 
                 3,5-(CF3)2 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 8-169 
                 3,5-(CF3)2 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
               
               
                 8-170 
                 3-CF3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 8-171 
                 3-CF3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
               
               
                 8-172 
                 3-CF3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2CF3 
               
               
                 8-173 
                 3-CF3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 8-174 
                 3-CF3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2SO2Me 
               
               
                 8-175 
                 3-CF3 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 8-176 
                 3-CF3 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
               
               
                 8-177 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 O 
                 C═O 
               
               
                 8-178 
                 3,5-Cl2 
                 CH2 
                 C═O 
                 O 
                 CH2 
               
               
                 8-179 
                 3,5-Cl2 
                 CH 
                 N 
                 CH 
                 O 
               
               
                 8-180 
                 3,5-Cl2 
                 CH 
                 N 
                 CH 
                 S 
               
               
                 8-181 
                 3,5-Cl2 
                 CH 
                 N 
                 CH 
                 NH 
               
               
                 8-182 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 C═O 
               
               
                 8-183 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 C═O 
                 CH2 
               
               
                 8-184 
                 3,5-Cl2 
                 CH2 
                 C═O 
                 CH2 
                 CH2 
               
               
                 8-185 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 C═O 
                 NCOCH3 
               
               
                 8-186 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 C═O 
                 NCOCH2CF3 
               
               
                 8-187 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NCOCH3 
               
               
                 8-188 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NCOC2H5 
               
               
                 8-189 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NCOCH2CF3 
               
               
                 8-190 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 8-191 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 8-192 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 8-193 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 NCOCH3 
                 CH2 
               
               
                 8-194 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 NCOC2H5 
                 CH2 
               
               
                 8-195 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 NCOCH2CF3 
                 CH2 
               
               
                 8-196 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 8-197 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 8-198 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 8-199 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 8-200 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
               
               
                 8-201 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2CF3 
               
               
                 8-202 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 8-203 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2Pr-c 
               
               
                 8-204 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2SMe 
               
               
                 8-205 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2SOMe 
               
               
                 8-206 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2SO2Me 
               
               
                 8-207 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH3 
               
               
                 8-208 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 8-209 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH2CCH 
               
               
                 8-210 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
               
               
                 8-211 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 8-212 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 8-213 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHOC(═O)CH3 
               
               
                 8-214 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 8-215 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═S)NHC2H5 
               
               
                 8-216 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCSC2H5 
               
               
                 8-217 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
                 CH2 
               
               
                 8-218 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
                 CH2 
               
               
                 8-219 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 C═O 
                 CH2 
               
               
                 8-220 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 8-221 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHCOCH3 
               
               
                 8-222 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHCOC2H5 
               
               
                 8-223 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHCOCH2CF3 
               
               
                 8-224 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHCOPr-c 
               
               
                 8-225 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHCOCH2SMe 
               
               
                 8-226 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHCOCH2SOMe 
               
               
                 8-227 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHCOCH2SO2Me 
               
               
                 8-228 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHC(═O)NHC2H5 
               
               
                 8-229 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHCO2C4H9-t 
               
               
                 8-230 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 COC(═O)CH3 
               
               
                 8-231 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CN3 
               
               
                 8-232 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH3 
               
               
                 8-233 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOC2H5 
               
               
                 8-234 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH2CF3 
               
               
                 8-235 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOPr-c 
               
               
                 8-236 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH2SMe 
               
               
                 8-237 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH2SOMe 
               
               
                 8-238 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH2SO2Me 
               
               
                 8-239 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHC(═O)NHC2H5 
               
               
                 8-240 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHCO2C4H9-t 
               
               
                 8-241 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CHCH3 
                 NNHCO2C4H9-t 
               
               
                 8-242 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 C(CH3)2 
                 NNHCO2C4H9-t 
               
               
                 8-243 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CHCl 
                 NNHCO2C4H9-t 
               
               
                 8-244 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CHF 
                 NNHCO2C4H9-t 
               
               
                 8-245 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 O 
                 C═O 
               
               
                 8-246 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 O 
                 CH2 
               
               
                 8-247 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 O 
               
               
                 8-248 
                 3,4,5-Cl3 
                 CH2 
                 C═O 
                 O 
                 CH2 
               
               
                 8-249 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 C═O 
               
               
                 8-250 
                 3,4,5-Cl3 
                 CH2 
                 CH 
                 CH 
                 C═O 
               
               
                 8-251 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 C═O 
                 CH2 
               
               
                 8-252 
                 3,4,5-Cl3 
                 CH2 
                 C═O 
                 CH2 
                 CH2 
               
               
                 8-253 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 C═O 
                 NCOCH3 
               
               
                 8-254 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 C═O 
                 NCOCH2CF3 
               
               
                 8-255 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NCOCH3 
               
               
                 8-256 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NCOC2H5 
               
               
                 8-257 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NCOCH2CF3 
               
               
                 8-258 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 8-259 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 8-260 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 8-261 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 NCOCH3 
                 CH2 
               
               
                 8-262 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 NCOC2H5 
                 CH2 
               
               
                 8-263 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 NCOCH2CF3 
                 CH2 
               
               
                 8-264 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 8-265 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 8-266 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 8-267 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 8-268 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
               
               
                 8-269 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2CF3 
               
               
                 8-270 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 8-271 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2Pr-c 
               
               
                 8-272 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2SMe 
               
               
                 8-273 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2SOMe 
               
               
                 8-274 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2SO2Me 
               
               
                 8-275 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH3 
               
               
                 8-276 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 8-277 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH2CCH 
               
               
                 8-278 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
               
               
                 8-279 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 8-280 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 8-281 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHOC(═O)CH3 
               
               
                 8-282 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 8-283 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═S)NHC2H5 
               
               
                 8-284 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCSC2H5 
               
               
                 8-285 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
                 CH2 
               
               
                 8-286 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
                 CH2 
               
               
                 8-287 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 C═O 
                 CH2 
               
               
                 8-288 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 8-289 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHCOCH3 
               
               
                 8-290 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHCOC2H5 
               
               
                 8-291 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHCOCH2CF3 
               
               
                 8-292 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHCOPr-c 
               
               
                 8-293 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHCOCH2SMe 
               
               
                 8-294 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHCOCH2SOMe 
               
               
                 8-295 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHCOCH2SO2Me 
               
               
                 8-296 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHC(═O)NHC2H5 
               
               
                 8-297 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHCO2C4H9-t 
               
               
                 8-298 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 COC(═O)CH3 
               
               
                 8-299 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CN3 
               
               
                 8-300 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH3 
               
               
                 8-301 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOC2H5 
               
               
                 8-302 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH2CF3 
               
               
                 8-303 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOPr-c 
               
               
                 8-304 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH2SMe 
               
               
                 8-305 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH2SOMe 
               
               
                 8-306 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH2SO2Me 
               
               
                 8-307 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHC(═O)NHC2H5 
               
               
                 8-308 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHCO2C4H9-t 
               
               
                 8-309 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CHCH3 
                 NNHCO2C4H9-t 
               
               
                 8-310 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 C(CH3)2 
                 NNHCO2C4H9-t 
               
               
                 8-311 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CHCL 
                 NNHCO2C4H9-t 
               
               
                 8-312 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CHF 
                 NNHCO2C4H9-t 
               
               
                 8-313 
                 3,5-(CF3)2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 8-314 
                 3,5-(CF3)2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
               
               
                 8-315 
                 3,5-(CF3)2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2CF3 
               
               
                 8-316 
                 3,5-(CF3)2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 8-317 
                 3,5-(CF3)2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2SO2Me 
               
               
                 8-318 
                 3,5-(CF3)2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 8-319 
                 3,5-(CF3)2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
               
               
                 8-320 
                 3-CF3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 8-321 
                 3-CF3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
               
               
                 8-322 
                 3-CF3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2CF3 
               
               
                 8-323 
                 3-CF3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 8-324 
                 3-CF3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2SO2Me 
               
               
                 8-325 
                 3-CF3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 8-326 
                 3-CF3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 9 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Example 
                 Xm 
                 W 1   
                 W 2   
                 W 3   
                 W 4   
               
               
                   
               
               
                 9-1 
                 3,5-Cl2 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 9-2 
                 3,5-Cl2 
                 — 
                 CH2 
                 O 
                 CH2 
               
               
                 9-3 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 O 
               
               
                 9-4 
                 3,5-Cl2 
                 — 
                 O 
                 CH2 
                 O 
               
               
                 9-5 
                 3,5-Cl2 
                 — 
                 O 
                 CF2 
                 O 
               
               
                 9-6 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 O 
               
               
                 9-7 
                 3,5-Cl2 
                 — 
                 C═O 
                 O 
                 CH2 
               
               
                 9-8 
                 3,5-Cl2 
                 — 
                 N 
                 CH 
                 O 
               
               
                 9-9 
                 3,5-Cl2 
                 — 
                 N 
                 CH 
                 S 
               
               
                 9-10 
                 3,5-Cl2 
                 — 
                 N 
                 CH 
                 NH 
               
               
                 9-11 
                 3,5-Cl2 
                 — 
                 O 
                 CH 
                 N 
               
               
                 9-12 
                 3,5-Cl2 
                 — 
                 S 
                 CH 
                 N 
               
               
                 9-13 
                 3,5-Cl2 
                 — 
                 CH 
                 N 
                 O 
               
               
                 9-14 
                 3,5-Cl2 
                 — 
                 CH 
                 N 
                 S 
               
               
                 9-15 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 C═O 
               
               
                 9-16 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 C═O 
               
               
                 9-17 
                 3,5-Cl2 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 9-18 
                 3,5-Cl2 
                 — 
                 C═O 
                 CH2 
                 CH2 
               
               
                 9-19 
                 3,5-Cl2 
                 — 
                 CH2 
                 C═O 
                 NCOCH3 
               
               
                 9-20 
                 3,5-Cl2 
                 — 
                 CH2 
                 C═O 
                 NCOCH2CF3 
               
               
                 9-21 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NCOCH3 
               
               
                 9-22 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NCOC2H5 
               
               
                 9-23 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NCOCH2CF3 
               
               
                 9-24 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 9-25 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 9-26 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 9-27 
                 3,5-Cl2 
                 — 
                 CH2 
                 NCOCH3 
                 CH2 
               
               
                 9-28 
                 3,5-Cl2 
                 — 
                 CH2 
                 NCOC2H5 
                 CH2 
               
               
                 9-29 
                 3,5-Cl2 
                 — 
                 CH2 
                 NCOCH2CF3 
                 CH2 
               
               
                 9-30 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 9-31 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 9-32 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 9-33 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 9-34 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
               
               
                 9-35 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2CF3 
               
               
                 9-36 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 9-37 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2Pr-c 
               
               
                 9-38 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2SMe 
               
               
                 9-39 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2SOMe 
               
               
                 9-40 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2SO2Me 
               
               
                 9-41 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH3 
               
               
                 9-42 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 9-43 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH2CCH 
               
               
                 9-44 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
               
               
                 9-45 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 9-46 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 9-47 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHOC(═O)CH3 
               
               
                 9-48 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 9-49 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═S)NHC2H5 
               
               
                 9-50 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 CHNHCSC2H5 
               
               
                 9-51 
                 3,5-Cl2 
                 — 
                 CH2 
                 CHNHCOC2H5 
                 CH2 
               
               
                 9-52 
                 3,5-Cl2 
                 — 
                 CH2 
                 CHNHCO2C4H9-t 
                 CH2 
               
               
                 9-53 
                 3,5-Cl2 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 9-54 
                 3,5-Cl2 
                 — 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 9-55 
                 3,5-Cl2 
                 — 
                 O 
                 N 
                 CHNHCO2C4H9-t 
               
               
                 9-56 
                 3,5-Cl2 
                 — 
                 NCH3 
                 N 
                 CHNHCO2C4H9-t 
               
               
                 9-57 
                 3,5-Cl2 
                 — 
                 SO2 
                 N 
                 CHNHCO2C4H9-t 
               
               
                 9-58 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHCOCH3 
               
               
                 9-59 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHCOC2H5 
               
               
                 9-60 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHCOCH2CF3 
               
               
                 9-61 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHCOPr-c 
               
               
                 9-62 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHCOCH2SMe 
               
               
                 9-63 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHCOCH2SOMe 
               
               
                 9-64 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHCOCH2SO2Me 
               
               
                 9-65 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHC(═O)NHC2H5 
               
               
                 9-66 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHNHCO2C4H9-t 
               
               
                 9-67 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHOC(═O)CH3 
               
               
                 9-68 
                 3,5-Cl2 
                 — 
                 CH 
                 CH 
                 CHN3 
               
               
                 9-69 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH3 
               
               
                 9-70 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHCOC2H5 
               
               
                 9-71 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH2CF3 
               
               
                 9-72 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHCOPr-c 
               
               
                 9-73 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH2SMe 
               
               
                 9-74 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH2SOMe 
               
               
                 9-75 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH2SO2Me 
               
               
                 9-76 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHC(═O)NHC2H5 
               
               
                 9-77 
                 3,5-Cl2 
                 — 
                 CH2 
                 CH2 
                 NNHCO2C4H9-t 
               
               
                 9-78 
                 3,5-Cl2 
                 — 
                 CH2 
                 CHCH3 
                 NNHCO2C4H9-t 
               
               
                 9-79 
                 3,5-Cl2 
                 — 
                 CH2 
                 C(CH3)2 
                 NNHCO2C4H9-t 
               
               
                 9-80 
                 3,5-Cl2 
                 — 
                 CH2 
                 CHCl 
                 NNHCO2C4H9-t 
               
               
                 9-81 
                 3,5-Cl2 
                 — 
                 CH2 
                 CHF 
                 NNHCO2C4H9-t 
               
               
                 9-82 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 O 
                 C═O 
               
               
                 9-83 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 O 
                 CH2 
               
               
                 9-84 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 O 
               
               
                 9-85 
                 3,4,5-Cl3 
                 — 
                 O 
                 CH2 
                 O 
               
               
                 9-86 
                 3,4,5-Cl3 
                 — 
                 O 
                 CF2 
                 O 
               
               
                 9-87 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 O 
               
               
                 9-88 
                 3,4,5-Cl3 
                 — 
                 C═O 
                 O 
                 CH2 
               
               
                 9-89 
                 3,4,5-Cl3 
                 — 
                 N 
                 CH 
                 O 
               
               
                 9-90 
                 3,4,5-Cl3 
                 — 
                 N 
                 CH 
                 S 
               
               
                 9-91 
                 3,4,5-Cl3 
                 — 
                 N 
                 CH 
                 NH 
               
               
                 9-92 
                 3,4,5-Cl3 
                 — 
                 O 
                 CH 
                 N 
               
               
                 9-93 
                 3,4,5-Cl3 
                 — 
                 S 
                 CH 
                 N 
               
               
                 9-94 
                 3,4,5-Cl3 
                 — 
                 CH 
                 N 
                 O 
               
               
                 9-95 
                 3,4,5-Cl3 
                 — 
                 CH 
                 N 
                 S 
               
               
                 9-96 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 C═O 
               
               
                 9-97 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 C═O 
               
               
                 9-98 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 9-99 
                 3,4,5-Cl3 
                 — 
                 C═O 
                 CH2 
                 CH2 
               
               
                 9-100 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 C═O 
                 NCOCH3 
               
               
                 9-101 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 C═O 
                 NCOCH2CF3 
               
               
                 9-102 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NCOCH3 
               
               
                 9-103 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NCOC2H5 
               
               
                 9-104 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NCOCH2CF3 
               
               
                 9-105 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 9-106 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 9-107 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 9-108 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 NCOCH3 
                 CH2 
               
               
                 9-109 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 NCOC2H5 
                 CH2 
               
               
                 9-110 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 NCOCH2CF3 
                 CH2 
               
               
                 9-111 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 9-112 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 9-113 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 9-114 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 9-115 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
               
               
                 9-116 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2CF3 
               
               
                 9-117 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 9-118 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2Pr-c 
               
               
                 9-119 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2SMe 
               
               
                 9-120 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2SOMe 
               
               
                 9-121 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2SO2Me 
               
               
                 9-122 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH3 
               
               
                 9-123 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 9-124 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH2CCH 
               
               
                 9-125 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
               
               
                 9-126 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 9-127 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 9-128 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHOC(═O)CH3 
               
               
                 9-129 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 9-130 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═S)NHC2H5 
               
               
                 9-131 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 CHNHCSC2H5 
               
               
                 9-132 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CHNHCOC2H5 
                 CH2 
               
               
                 9-133 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CHNHCO2C4H9-t 
                 CH2 
               
               
                 9-134 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 C═O 
                 CH2 
               
               
                 9-135 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 9-136 
                 3,4,5-Cl3 
                 — 
                 O 
                 N 
                 CHNHCO2C4H9-t 
               
               
                 9-137 
                 3,4,5-Cl3 
                 — 
                 NCH3 
                 N 
                 CHNHCO2C4H9-t 
               
               
                 9-138 
                 3,4,5-Cl3 
                 — 
                 SO2 
                 N 
                 CHNHCO2C4H9-t 
               
               
                 9-139 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHCOCH3 
               
               
                 9-140 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHCOC2H5 
               
               
                 9-141 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHCOCH2CF3 
               
               
                 9-142 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHCOPr-c 
               
               
                 9-143 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHCOCH2SMe 
               
               
                 9-144 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHCOCH2SOMe 
               
               
                 9-145 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHCOCH2SO2Me 
               
               
                 9-146 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHC(═O)NHC2H5 
               
               
                 9-147 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHNHCO2C4H9-t 
               
               
                 9-148 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHOC(═O)CH3 
               
               
                 9-149 
                 3,4,5-Cl3 
                 — 
                 CH 
                 CH 
                 CHN3 
               
               
                 9-150 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH3 
               
               
                 9-151 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHCOC2H5 
               
               
                 9-152 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH2CF3 
               
               
                 9-153 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHCOPr-c 
               
               
                 9-154 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH2SMe 
               
               
                 9-155 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH2SOMe 
               
               
                 9-156 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHCOCH2SO2Me 
               
               
                 9-157 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHC(═O)NHC2H5 
               
               
                 9-158 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CH2 
                 NNHCO2C4H9-t 
               
               
                 9-159 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CHCH3 
                 NNHCO2C4H9-t 
               
               
                 9-160 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 C(CH3)2 
                 NNHCO2C4H9-t 
               
               
                 9-161 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CHCl 
                 NNHCO2C4H9-t 
               
               
                 9-162 
                 3,4,5-Cl3 
                 — 
                 CH2 
                 CHF 
                 NNHCO2C4H9-t 
               
               
                 9-163 
                 3,5-(CF3)2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 9-164 
                 3,5-(CF3)2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
               
               
                 9-165 
                 3,5-(CF3)2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2CF3 
               
               
                 9-166 
                 3,5-(CF3)2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 9-167 
                 3,5-(CF3)2 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2SO2Me 
               
               
                 9-168 
                 3,5-(CF3)2 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 9-169 
                 3,5-(CF3)2 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
               
               
                 9-170 
                 3-CF3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 9-171 
                 3-CF3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
               
               
                 9-172 
                 3-CF3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2CF3 
               
               
                 9-173 
                 3-CF3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 9-174 
                 3-CF3 
                 — 
                 CH2 
                 CH2 
                 CHNHCOCH2SO2Me 
               
               
                 9-175 
                 3-CF3 
                 — 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 9-176 
                 3-CF3 
                 — 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
               
               
                 9-177 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 O 
                 C═O 
               
               
                 9-178 
                 3,5-Cl2 
                 CH2 
                 C═O 
                 O 
                 CH2 
               
               
                 9-179 
                 3,5-Cl2 
                 CH 
                 N 
                 CH 
                 O 
               
               
                 9-180 
                 3,5-Cl2 
                 CH 
                 N 
                 CH 
                 S 
               
               
                 9-181 
                 3,5-Cl2 
                 CH 
                 N 
                 CH 
                 NH 
               
               
                 9-182 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 C═O 
               
               
                 9-183 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 C═O 
                 CH2 
               
               
                 9-184 
                 3,5-Cl2 
                 CH2 
                 C═O 
                 CH2 
                 CH2 
               
               
                 9-185 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 C═O 
                 NCOCH3 
               
               
                 9-186 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 C═O 
                 NCOCH2CF3 
               
               
                 9-187 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NCOCH3 
               
               
                 9-188 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NCOC2H5 
               
               
                 9-189 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NCOCH2CF3 
               
               
                 9-190 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 9-191 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 9-192 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 9-193 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 NCOCH3 
                 CH2 
               
               
                 9-194 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 NCOC2H5 
                 CH2 
               
               
                 9-195 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 NCOCH2CF3 
                 CH2 
               
               
                 9-196 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 9-197 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 9-198 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 9-199 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 9-200 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
               
               
                 9-201 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2CF3 
               
               
                 9-202 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 9-203 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2Pr-c 
               
               
                 9-204 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2SMe 
               
               
                 9-205 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2SOMe 
               
               
                 9-206 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2SO2Me 
               
               
                 9-207 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH3 
               
               
                 9-208 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 9-209 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH2CCH 
               
               
                 9-210 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
               
               
                 9-211 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 9-212 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 9-213 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHOC(═O)CH3 
               
               
                 9-214 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 9-215 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═S)NHC2H5 
               
               
                 9-216 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCSC2H5 
               
               
                 9-217 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
                 CH2 
               
               
                 9-218 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
                 CH2 
               
               
                 9-219 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 C═O 
                 CH2 
               
               
                 9-220 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 9-221 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHCOCH3 
               
               
                 9-222 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHCOC2H5 
               
               
                 9-223 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHCOCH2CF3 
               
               
                 9-224 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHCOPr-c 
               
               
                 9-225 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHCOCH2SMe 
               
               
                 9-226 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHCOCH2SOMe 
               
               
                 9-227 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHCOCH2SO2Me 
               
               
                 9-228 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHC(═O)NHC2H5 
               
               
                 9-229 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CNHCO2C4H9-t 
               
               
                 9-230 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 COC(═O)CH3 
               
               
                 9-231 
                 3,5-Cl2 
                 CH 
                 CH 
                 CH 
                 CN3 
               
               
                 9-232 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH3 
               
               
                 9-233 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOC2H5 
               
               
                 9-234 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH2CF3 
               
               
                 9-235 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOPr-c 
               
               
                 9-236 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH2SMe 
               
               
                 9-237 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH2SOMe 
               
               
                 9-238 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH2SO2Me 
               
               
                 9-239 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHC(═O)NHC2H5 
               
               
                 9-240 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CH2 
                 NNHCO2C4H9-t 
               
               
                 9-241 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CHCH3 
                 NNHCO2C4H9-t 
               
               
                 9-242 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 C(CH3)2 
                 NNHCO2C4H9-t 
               
               
                 9-243 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CHCl 
                 NNHCO2C4H9-t 
               
               
                 9-244 
                 3,5-Cl2 
                 CH2 
                 CH2 
                 CHF 
                 NNHCO2C4H9-t 
               
               
                 9-245 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 O 
                 C═O 
               
               
                 9-246 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 O 
                 CH2 
               
               
                 9-247 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 O 
               
               
                 9-248 
                 3,4,5-Cl3 
                 CH2 
                 C═O 
                 O 
                 CH2 
               
               
                 9-249 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 C═O 
               
               
                 9-250 
                 3,4,5-Cl3 
                 CH2 
                 CH 
                 CH 
                 C═O 
               
               
                 9-251 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 C═O 
                 CH2 
               
               
                 9-252 
                 3,4,5-Cl3 
                 CH2 
                 C═O 
                 CH2 
                 CH2 
               
               
                 9-253 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 C═O 
                 NCOCH3 
               
               
                 9-254 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 C═O 
                 NCOCH2CF3 
               
               
                 9-255 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NCOCH3 
               
               
                 9-256 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NCOC2H5 
               
               
                 9-257 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NCOCH2CF3 
               
               
                 9-258 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH3 
               
               
                 9-259 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NC2H5 
               
               
                 9-260 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 N(C═O)NCH2CCH 
               
               
                 9-261 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 NCOCH3 
                 CH2 
               
               
                 9-262 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 NCOC2H5 
                 CH2 
               
               
                 9-263 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 NCOCH2CF3 
                 CH2 
               
               
                 9-264 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 C═NOH 
               
               
                 9-265 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH3 
               
               
                 9-266 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 C═NOCH2CF3 
               
               
                 9-267 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 9-268 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
               
               
                 9-269 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2CF3 
               
               
                 9-270 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 9-271 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2Pr-c 
               
               
                 9-272 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2SMe 
               
               
                 9-273 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2SOMe 
               
               
                 9-274 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2SO2Me 
               
               
                 9-275 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH3 
               
               
                 9-276 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 9-277 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHCH2CCH 
               
               
                 9-278 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
               
               
                 9-279 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2CH3 
               
               
                 9-280 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2Ph 
               
               
                 9-281 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHOC(═O)CH3 
               
               
                 9-282 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHN3 
               
               
                 9-283 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═S)NHC2H5 
               
               
                 9-284 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCSC2H5 
               
               
                 9-285 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
                 CH2 
               
               
                 9-286 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
                 CH2 
               
               
                 9-287 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 C═O 
                 CH2 
               
               
                 9-288 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 C═NOH 
                 CH2 
               
               
                 9-289 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHCOCH3 
               
               
                 9-290 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHCOC2H5 
               
               
                 9-291 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHCOCH2CF3 
               
               
                 9-292 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHCOPr-c 
               
               
                 9-293 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHCOCH2SMe 
               
               
                 9-294 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHCOCH2SOMe 
               
               
                 9-295 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHCOCH2SO2Me 
               
               
                 9-296 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHC(═O)NHC2H5 
               
               
                 9-297 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CNHCO2C4H9-t 
               
               
                 9-298 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 COC(═O)CH3 
               
               
                 9-299 
                 3,4,5-Cl3 
                 CH 
                 CH 
                 CH 
                 CN3 
               
               
                 9-300 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH3 
               
               
                 9-301 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOC2H5 
               
               
                 9-302 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH2CF3 
               
               
                 9-303 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOPr-c 
               
               
                 9-304 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH2SMe 
               
               
                 9-305 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH2SOMe 
               
               
                 9-306 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHCOCH2SO2Me 
               
               
                 9-307 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHC(═O)NHC2H5 
               
               
                 9-308 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CH2 
                 NNHCO2C4H9-t 
               
               
                 9-309 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CHCH3 
                 NNHCO2C4H9-t 
               
               
                 9-310 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 C(CH3)2 
                 NNHCO2C4H9-t 
               
               
                 9-311 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CHCl 
                 NNHCO2C4H9-t 
               
               
                 9-312 
                 3,4,5-Cl3 
                 CH2 
                 CH2 
                 CHF 
                 NNHCO2C4H9-t 
               
               
                 9-313 
                 3,5-(CF3)2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 9-314 
                 3,5-(CF3)2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
               
               
                 9-315 
                 3,5-(CF3)2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2CF3 
               
               
                 9-316 
                 3,5-(CF3)2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 9-317 
                 3,5-(CF3)2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2SO2Me 
               
               
                 9-318 
                 3,5-(CF3)2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 9-319 
                 3,5-(CF3)2 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
               
               
                 9-320 
                 3-CF3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH3 
               
               
                 9-321 
                 3-CF3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOC2H5 
               
               
                 9-322 
                 3-CF3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2CF3 
               
               
                 9-323 
                 3-CF3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOPr-c 
               
               
                 9-324 
                 3-CF3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCOCH2SO2Me 
               
               
                 9-325 
                 3-CF3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHC(═O)NHC2H5 
               
               
                 9-326 
                 3-CF3 
                 CH2 
                 CH2 
                 CH2 
                 CHNHCO2C4H9-t 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
             
               
                   
               
               
                 No. 
                 1H-NMR 
               
               
                   
               
             
            
               
                 1-2 
                 1H-NMR (CDCl3) δ: 3.94 (2H, m), 5.36 (2H, s), 7.44-7.51 (3H, m), 7.78-8.04 (3H, m). 
               
               
                 1-10 
                 1H-NMR (CDCl3) δ: 3.81 (1H, d), 4.25 (1H, d), 5.37 (2H, s), 7.80-7.83 (1H, m), 7.87-7.91 (1H, m), 7.99-8.02 (2H, m), 8.07-8.10 (2H, m) 
               
               
                 1-38 
                 1H-NMR (CDCl3) δ: 3.74 (1H, d), 4.13 (1H, d), 5.36 (2H, s), 7.63-7.66 (2H, m), 7.78-7.79 (1H, m), 7.85-7.88 (1H, m), 7.98-8.01 (1H, m) 
               
               
                 1-44 
                 1H-NMR (CDCl3) δ: 3.76 (1H, d), 4.19 (1H, d), 5.36 (2H, s), 7.80-7.86 (3H, m), 7.96-8.00 (2H, m) 
               
               
                 1-50 
                 1H-NMR (CDCl3) δ: 3.75 (1H, d), 4.14 (1H, d), 4.50 (2H, s), 6.48-6.49 (1H, m), 7.44-7.44 (1H, m), 7.51-7.52 (2H, m), 7.71-7.73 (1H, m), 
               
               
                   
                 7.86-7.89 (1H, m), 7.92-7.95 (1H, m) 
               
               
                 1-52 
                 1H-NMR (CDCl3) δ: 3.24 (3H, s), 3.72-4.16 (2H, m), 4.42 (2H, s), 7.43 (1H, m), 7.52 (2H, m), 7.67 (1H, m), 7.88 (2H, m). 
               
               
                 1-54 
                 1H-NMR (CDCl3) δ: 1.30 (3H, t), 3.69 (2H, q), 3.94 (2H, m), 4.42 (2H, s), 7.43 (1H, m), 7.52 (2H, m), 7.66 (1H, m), 7.88 (2H, m). 
               
               
                 1-56 
                 1H-NMR (CDCl3) δ: 3.72-3.78 (1H, m), 4.11-4.16 (1H, m), 4.24 (2H, q, J = 9.0 Hz), 4.60 (1H, s), 7.42-7.46 (1H, m), 7.51 (2H, s), 
               
               
                   
                 7.72 (1H, d, J = 7.9 Hz), 7.88 (1H, s), 7.95 (1H, d, J = 7.9 Hz). 
               
               
                 1-58 
                 1H-NMR (CDCl3) δ: 3.74 (1H, d), 4.12 (1H, d), 4.52 (2H, s), 4.93 (2H, s), 7.20-7.22 (1H, m), 7.31-7.34 (1H, m), 7.43-7.43 (1H, m), 
               
               
                   
                 7.51-7.51 (2H, m), 7.65-7.70 (2H, m), 7.80-7.83 (1H, m), 7.92-7.95 (1H, m), 8.55-8.57 (1H, m) 
               
               
                 1-60 
                 1H-NMR (CDCl3) δ: 0.97 (3H, t), 1.68-1.78 (2H, m), 3.60 (2H, t), 3.94 (2H, m), 4.41 (2H, s), 7.44 (1H, m), 7.52 (2H, m), 7.66 (1H, m), 
               
               
                   
                 7.88 (2H, m). 
               
               
                 1-61 
                 1H-NMR (CDCl3) δ: 1.31 (6H, d), 3.94 (2H, m), 4.37 (2H, s), 4.61-4.75 (1H, m), 7.44 (1H, m), 7.52 (2H, m), 7.64 (1H, m), 7.89 (2H, m). 
               
               
                 1-62 
                 1H-NMR (CDCl3) δ: 0.92 (4H, m), 2.92-2.99 (1H, m), 3.93 (2H, m), 4.38 (2H, s), 7.43 (1H, m), 7.51 (2H, m), 7.66 (1H, m), 7.86 (2H, m). 
               
               
                 1-64 
                 1H-NMR (CDCl3) δ: 0.97 (6H, d), 2.03-2.12 (1H, m), 3.44 (2H, d), 3.72-4.16 (2H, m), 4.44 (2H, s), 7.44 (1H, m), 7.52 (2H, m), 7.67 
               
               
                   
                 (1H, m), 7.90 (2H, m). 
               
               
                 1-67 
                 1H-NMR (CDCl3) δ: 3.94 (2H, m), 4.25 (2H, d), 4.42 (2H, s), 5.25 (2H, m), 5.87 (1H, m), 7.43 (1H, m), 7.52 (2H, m), 7.68 (1H, m), 
               
               
                   
                 7.90 (2H, m). 
               
               
                 1-69 
                 1H-NMR (CDCl3) δ: 3.35 (3H, s), 3.68 (2H, t), 3.76 (2H, t), 3.94 (2H, m), 4.57 (2H, s), 7.43 (1H, m), 7.52 (2H, m), 7.68 (1H, m), 
               
               
                   
                 7.80-7.94 (2H, m). 
               
               
                 1-79 
                 1H-NMR (CDCl3) δ: 3.93 (2H, m), 4.32 (2H, s), 4.81 (2H, s), 7.29-7.50 (8H, m), 7.68-7.95 (3H, s) 
               
               
                 1-80 
                 1H-NMR (acetone-d6) δ: 4.32 (1H, d), 4.48 (1H, d), 4.75 (2H, d), 5.02 (2H, d), 7.35 (1H, t), 7.65-7.61 (1H, m), 7.68 (2H, s), 7.82 
               
               
                   
                 (1H, d), 7.92 (1H, d), 8.01 (1H, s), 8.71 (2H, d) 
               
               
                 1-81 
                 1H-NMR (CDCl3) δ: 3.77 (1H, d), 4.15 (1H), 4.91 (2H, s), 7.22 (1H, t), 7.42-7.48 (3H, m), 7.53 (2H, s), 7.73 (1H, d), 7.87 (2H, d), 
               
               
                   
                 7.93 (1H, s), 7.99 (1H, d) 
               
               
                 1-89 
                 1H-NMR (acetone-d6) δ: 4.32 (1H, d), 4.48 (1H, d), 4.75 (2H, d), 5.02 (2H, d), 7.35 (1H, t), 7.65-7.61 (1H, m), 7.68 (2H, s), 7.82 
               
               
                   
                 (1H, d), 7.92 (1H, d), 8.01 (1H, s), 8.71 (2H, d) 
               
               
                 1-114 
                 1H-NMR (CDCl3) δ: 3.23 (3H, s), 3.93 (2H, m), 5.36 (2H, s), 7.64 (6H, m). 
               
               
                 1-115 
                 1H-NMR (CDCl3) δ: 3.92 (2H, m), 4.76 (2H, d), 5.24 (2H, d), 7.19-7.72 (7H, m), 7.93 (1H, s), 8.20 (1H, s), 8.54 (1H, d). 
               
               
                 1-116 
                 1H-NMR (CDCl3) δ: 3.95 (2H, m), 5.38 (2H, s), 7.44-7.61 (4H, m), 8.03 (1H, s), 8.20 (1H, d). 
               
               
                 1-117 
                 1H-NMR (CDCl3) δ: 3.98 (2H, m), 7.48 (3H, m), 8.19 (3H, m). 
               
               
                 1-120 
                 1H-NMR (CDCl3) δ: 3.21 (3H, s), 4.00 (2H, m), 7.44-7.51 (3H, m), 7.91 (1H, m), 8.06-8.11 (2H, m). 
               
               
                 1-121 
                 1H-NMR (CDCl3) δ: 3.57 (2H, s), 3.68 (1H, d), 4.06 (1H, t), 6.93 (1H, d), 7.40-7.50 (4H, m), 7.64 (1H, s), 9.02 (1H, s). 
               
               
                 1-122 
                 1H-NMR (CDCl3) δ: 2.07 (3H, s), 3.71-3.73 (1H, m), 4.01-4.07 (1H, m), 4.28 (1H, s), 6.93 (1H, d), 7.43 (1H, d, J = 0.9 Hz), 
               
               
                   
                 7.53-7.59 (3H, m), 7.71 (1H, d), 8.09 (1H, s). 
               
               
                 1-125 
                 1H-NMR (CDCl3) δ: 3.72 (1H, d), 4.10-4.17 (3H, m), 7.15 (1H, s), 7.44 (1H, s), 7.49-7.53 (2H, m), 7.61-7.64 (2H, m), 8.12-8.14 
               
               
                   
                 (1H, m) 
               
               
                 1-126 
                 1H-NMR (CDCl3) δ: 2.61 (3H, s), 3.74 (1H, d), 4.13 (1H, d), 4.24 (2H, s), 7.43 (1H, s), 7.51 (2H, s), 7.61-7.64 (2H, m), 7.83 
               
               
                   
                 (1H, s), 8.11 (1H, d) 
               
               
                 1-127 
                 1H-NMR (CDCl3) δ: 2.51 (3H, s), 3.23 (3H, s), 3.72 (1H, d), 4.11 (1H, d), 4.23 (2H, s), 7.43-7.44 (1H, m), 7.51 (2H, s), 7.59-7.60 
               
               
                   
                 (2H, m), 8.10 (1H, d) 
               
               
                 1-129 
                 1H-NMR (CDCl3) δ: 3.83 (1H, d), 4.20 (1H, d), 7.44-7.44 (1H, m), 7.52-7.53 (2H, m), 7.99-7.99 (1H, m), 8.09-8.12 (1H, m), 8.20-8.24 
               
               
                   
                 (1H, m), 8.47-8.50 (1H, m), 11.25 (1H, br s) 
               
               
                 1-131 
                 1H-NMR (CDCl3) δ: 3.72 (1H, d), 4.11 (1H, d), 5.11 (4H, s), 7.27-7.30 (1H, m), 7.41-7.41 (1H, m), 7.51-7.57 (4H, m) 
               
               
                 1-132 
                 1H-NMR (CDCl3) δ: 3.72 (1H, d), 4.11 (1H, d), 5.12 (4H, s), 7.28-7.30 (1H, m), 7.53-7.57 (2H, m), 7.63-7.66 (2H, m) 
               
               
                 1-134 
                 1H-NMR (CDCl3) δ: 3.64 (1H, d), 4.03 (1H, d), 6.02 (2H, s), 6.83-6.85 (1H, m), 7.01-7.03 (1H, m), 7.41-7.43 (1H, m), 7.49-7.50 (3H, m) 
               
               
                 1-135 
                 1H-NMR (CDCl3) δ: 3.83 (1H, d), 4.24 (1H, d), 6.04 (2H, s), 6.86 (1H, s), 7.16 (1H, s), 7.42-7.43 (1H, m), 7.48-7.49 (2H, m) 
               
               
                 1-136 
                 1H-NMR (CDCl3) δ: 3.23 (2H, t), 3.66 (1H, d), 4.06 (1H, d), 4.63 (2H, t), 6.78-6.81 (1H, m), 7.33-7.36 (1H, m), 7.40-7.41 (1H, m), 
               
               
                   
                 7.51-7.51 (2H, m), 7.59-7.60 (1H, m) 
               
               
                 1-141 
                 1.58 (bs, 1H), 3.05 (t, 2H), 3.57-3.69 (m, 3H), 4.04 (d, 1H), 6.56 (d, 1H), 7.23 (d, 1H), 7.40 (s, 1H), 7.47 (s, 1H), 7.51 (s, 2H) 
               
               
                 1-142 
                 1H-NMR (CDCl3) δ: 2.81 (s, 3H), 2.98 (t, 2H), 3.43 (t, 2H), 3.63 (d, 1H), 4.03 (d, 1H), 6.37 (d, 1H), 7.26 (d, 1H), 7.40 (s, 1H), 
               
               
                   
                 7.44 (s, 1H), 7.52 (s, 2H) 
               
               
                 1-145 
                 1H-NMR (CDCl3) δ: 2.25 (s, 3H), 3.23 (t, 2H), 3.68 (d, 1H), 4.02-4.16 (m, 3H), 7.34 (d, 1H), 7.42 (s, 1H), 7.51 (s, 2H), 7.63 (s, 1H), 
               
               
                   
                 8.23 (d, 1H) 
               
               
                 1-146 
                 1H-NMR (CDCl3) δ: 3.30 (t, 2H), 3.69 (d, 1H), 4.08 (d, 1H), 4.34 (t, 2H), 7.39-7.47 (m, 2H), 7.51 (s, 2H), 7.71 (s, 1H), 8.24 (d, 1H) 
               
               
                 1-149 
                 1H-NMR (CDCl3) δ: 3.87 (2H, m), 3.91 (2H, s), 3.95 (4H, s), 7.21-7.51 (11H, m). 
               
               
                 1-150 
                 1H-NMR (CDCl3) δ: 3.89 (2H, m), 4.04 (4H, s), 4.08 (2H, s), 7.19-7.70 (9H, m), 8.59 (1H, d, J = 4.9 Hz). 
               
               
                 1-151 
                 1H-NMR (CDCl3) δ: 2.18 (3H, s), 3.71 (1H, d), 4.10 (1H, d), 4.82-4.85 (4H, m), 7.32-7.39 (1H, m), 7.43-7.43 (1H, m), 7.52-7.65 (4H, m) 
               
               
                 1-155 
                 1H-NMR (CDCl3) δ: 3.79 (d, 1H), 4.18 (d, 1H), 6.59 (s, 1H), 7.37-7.85 (m, 7H), 8.34 (bs, 1H) 
               
               
                 1-157 
                 1H-NMR (CDCl3) δ: 3.77 (d, 1H), 4.17 (d, 1H), 6.59 (d, 1H), 7.42 (s, 1H), 7.54 (s, 2H), 7.61-7.70 (m, 2H), 7.82 (s, 1H), 8.19 (d, 1H) 
               
               
                 1-163 
                 1H-NMR (CDCl3) δ: 3.85 (1H, d), 4.23 (1H, d), 7.43-7.50 (2H, m), 7.55 (2H, s), 7.87 (1H, d), 8.05-8.14 (2H, m), 8.18 (1H, d), 
               
               
                   
                 9.00-8.93 (1H, m) 
               
               
                 1-164 
                 1H-NMR (CDCl3) δ: 3.83 (d, 1H), 4.23 (d, 1H), 7.41-7.59 (m, 4H), 7.95 (s, 1H), 8.13-8.22 (m, 3H), 8.95-9.00 (m, 1H) 
               
               
                 1-165 
                 1H-NMR (CDCl3) δ: 1.86-2.00 (2H, m), 2.68-2.83 (2H, m), 3.24-3.40 (2H, m), 3.62 (1H, d), 3.95 (1H, s), 4.02 (1H, d), 6.73-6.86 
               
               
                   
                 (2H, m), 6.96 (1H, d), 7.41 (1H, s), 7.49 (2H, s) 
               
               
                 1-169 
                 1H-NMR (CDCl3) δ: 1.55 (bs, 1H), 1.87-1.98 (m, 2H), 2.75 (t, 2H), 3.35 (t, 2H), 3.61 (d, 1H), 4.02 (d, 1H), 6.43 (d, 1H), 7.20-7.29 
               
               
                   
                 (m, 2H), 7.40 (s, 1H), 7.51 (s, 2H) 
               
               
                 1-170 
                 1H-NMR (CDCl3) δ: 1.90-2.02 (m, 2H), 2.75 (t, 2H), 2.94 (s, 3H), 3.31 (t, 2H), 3.62 (d, 1H), 4.03 (d, 1H), 6.51 (d, 1H), 7.23-7.33 
               
               
                   
                 (m, 2H), 7.39 (s, 1H), 7.52 (s, 2H) 
               
               
                 1-171 
                 1H-NMR (CDCl3) δ: 1.90-2.02 (m, 2H), 2.26 (s, 3H), 2.77 (t, 2H), 3.68 (d, 1H), 3.77 (t, 2H), 4.07 (d, 1H), 7.37-7.56 (m, 6H) 
               
               
                 1-175 
                 1H-NMR (CDCl3) δ: 3.87 (1H, d), 4.25 (1H, d), 7.44-7.44 (1H, m), 7.55-7.55 (2H, m), 8.14-8.16 (2H, m), 8.29-8.32 (1H, m), 8.90 
               
               
                   
                 (2H, s). 
               
               
                 1-176 
                 1H-NMR (CDCl3) δ: 3.39-3.46 (4H, m), 3.60 (1H, d), 4.00 (1H, d), 6.41-6.43 (1H, m), 6.74-6.77 (1H, m), 6.88-6.89 (1H, m), 7.39-7.40 
               
               
                   
                 (1H, m), 7.50-7.50 (2H, m). 
               
               
                 1-182 
                 1H-NMR (CDCl3) δ: 3.78 (1H, d), 4.17 (1H, d), 7.42-7.43 (1H, m), 7.54-7.54 (2H, m), 7.63-7.66 (1H, m), 7.85-7.87 (1H, m), 8.00-8.00 
               
               
                   
                 (1H, m), 8.16 (1H, s). 
               
               
                 1-189 
                 1H-NMR (CDCl3) δ: 3.80 (1H, d), 4.16 (1H, d), 7.43-7.44 (1H, m), 7.53-7.53 (2H, m), 7.69-7.71 (1H, m), 7.83-7.86 (1H, m), 7.94-7.94 
               
               
                   
                 (1H, m), 8.19 (1H, s). 
               
               
                 1-209 
                 1H-NMR (CDCl3) δ: 2.74-2.76 (2H, m), 3.18-3.20 (2H, m), 3.75 (1H, d), 4.13 (1H, d), 7.44-7.44 (1H, m), 7.51-7.52 (2H, m), 7.66-7.69 
               
               
                   
                 (1H, m), 7.76-7.81 (2H, m) 
               
               
                 1-211 
                 1H-NMR (CDCl3) δ: 2.94-3.18 (5H, m), 3.66-3.77 (1H, m), 4.08-4.13 (1H, m), 7.42-7.43 (1H, m), 7.49-7.57 (3H, m), 7.63 (1H, s), 7.69 
               
               
                   
                 (1H, d, J = 8.1 Hz). 
               
               
                 1-213 
                 1H-NMR (CDCl3) δ: 2.85-2.96 (2H, m), 3.00-3.12 (2H, m), 3.71 (1H, d, J = 17.2 Hz), 4.01 (3H, s), 4.10 (1H, d, J = 17.2 Hz), 
               
               
                   
                 7.45-7.40 (1H, m), 7.57-7.49 (3H, m), 7.62 (1H, s), 7.73 (1H, d, J = 8.1 Hz). 
               
               
                 1-217 
                 1H-NMR (CDCl3) δ: 2.59-2.68 (m, 2H), 3.06-3.18 (m, 5H), 3.70 (d, 1H), 4.09 (d, 1H), 7.39-7.55 (m 4H), 7.60 (s, 1H), 7.70 (d, 1H) 
               
               
                 1-219 
                 1H-NMR (CDCl3) δ: 2.71 (s, 6H), 2.86-2.95 (m, 2H), 3.03-3.15 (m, 2H), 3.70 (d, 1H), 4.10 (d, 1H), 7.39-7.55 (m, 4H), 7.62 (s, 1H), 
               
               
                   
                 7.77 (d, 1H) 
               
               
                 1-221 
                 1H-NMR (CDCl3) δ: 2.70 (3H, s), 3.76 (1H, d, J = 17.0 Hz), 4.14 (1H, d, J = 17.4 Hz), 4.85 (2H, s), 7.44-7.45 (1H, m), 
               
               
                   
                 7.51-7.52 (2H, m), 7.81-7.83 (2H, m), 7.96-7.99 (1H, m) 
               
               
                 1-222 
                 1H-NMR (CDCl3) δ: 2.11-2.22 (m, 2H), 2.69 (t, 2H), 3.00 (t, 2H), 3.71 (d, 1H), 4.10 (d, 1H), 7.41-7.59 (m, 5H), 8.08 (d, 1H) 
               
               
                 1-223 
                 1H-NMR (CDCl3) δ: 1.56 (bs, 1H), 1.83-1.94 (m, 2H), 2.74-2.87 (m, 4H), 3.70 (d, 1H), 4.09 (d, 1H), 7.41-7.56 (m, 5H), 7.97 (d, 1H) 
               
               
                 1-224 
                 1H-NMR (CDCl3) δ: 1.78-1.90 (m, 2H), 2.68-2.80 (m, 4H), 3.69 (d, 1H), 4.01 (s, 3H), 4.08 (d, 1H), 7.39-7.55 (m, 5H), 8.03 (d, 1H) 
               
               
                 1-232 
                 1H-NMR (CDCl3) δ: 3.74 (1H, d), 4.12 (1H, d), 5.34 (2H, s), 7.44-7.44 (1H, m), 7.49-7.52 (2H, m), 7.71-7.73 (1H, m), 7.76-7.79 
               
               
                   
                 (1H, m), 7.92-7.95 (1H, m) 
               
               
                 1-235 
                 1H-NMR (CDCl3) δ: 2.12-2.24 (3H, m), 3.60-3.68 (1H, m), 4.02-4.08 (1H, m), 4.73-4.82 (4H, m), 7.13-7.73 (9H, m), 8.44-8.61 (1H, m) 
               
               
                 1-240 
                 1H-NMR (CDCl3) δ: 3.07 (t, 2H), 3.54-3.68 (m, 3H), 4.04 (d, 1H), 4.48 (s, 2H), 6.38 (d, 1H), 7.16-7.69 (m, 8H), 8.59 (d, 1H) 
               
               
                 1-241 
                 1H-NMR (CDCl3) δ: 2.95-3.14 (4H, m), 3.70 (1H, d), 4.09 (1H, d), 5.36 (2H, s), 7.17-7.24 (1H, m), 7.39-7.45 (2H, m), 7.47-7.55 
               
               
                   
                 (3H, m), 7.60-7.77 (3H, m), 8.60 (1H, d) 
               
               
                 1-242 
                 1H-NMR (CDCl3) δ: 2.39 (s, 3H), 2.73-2.85 (m, 2H), 3.14-3.23 (m, 2H), 3.72 (d, 1H), 4.11 (d, 1H), 7.43 (s, 1H), 7.52 (s, 2H), 7.59 
               
               
                   
                 (d, 1H), 7.63 (s, 1H), 7.78 (d, 1H), 8.70 (s, 1H) 
               
               
                 1-243 
                 1H-NMR (CDCl3) δ: 2.61-2.74 (m,. 2H), 3.07-3.23 (m, 2H), 3.70 (d, 1H), 3.91 (q, 2H), 4.10 (d, 1H), 5.09 (bs, 1H), 7.42 (s, 1H), 
               
               
                   
                 7.46-7.57 (m, 2H), 7.61 (s, 1H), 7.68 (d, 1H) 
               
               
                 1-244 
                 1H-NMR (CDCl3) δ: 2.93-3.13 (m, 4H), 3.70 (d, 1H), 4.09 (d, 1H), 4.54 (q, 2H), 7.43 (s, 1H), 7.51 (s, 2H), 7.56 (d, 1H), 7.63 (s, 1H), 
               
               
                   
                 7.72 (d, 1H) 
               
               
                 1-245 
                 1H-NMR (CDCl3) δ: 3.74 (1H, d), 4.12 (1H, d), 5.34 (2H, s), 7.44-7.44 (1H, m), 7.49-7.52 (2H, m), 7.71-7.73 (1H, m), 7.76-7.79 
               
               
                   
                 (1H, m), 7.92-7.95 (1H, m) 
               
               
                 1-246 
                 1H-NMR (CDCl3) δ: 3.33 (dd, 1H), 3.73 (d, 1H), 3.81 (dd, 1H), 4.12 (d, 1H), 4.59 (dd, 1H), 7.44 (s, 1H), 7.51 (s, 2H), 7.74 (d, 1H), 
               
               
                   
                 7.78 (s, 1H), 7.88 (d, 1H) 
               
               
                 1-247 
                 1H-NMR (CDCl3) δ: 3.74 (d, 1H), 4.12 (d, 1H), 7.44 (s, 1H), 7.52 (s, 2H), 7.56 (d, 1H), 7.72 (d, 1H), 8.02 (s, 1H) 
               
               
                 1-248 
                 1H-NMR (CDCl3) δ: 3.73-3.78 (3H, m), 4.13 (1H, d), 6.99-7.02 (2H, m), 7.29-7.32 (1H, m), 7.43-7.44 (1H, m), 7.51-7.52 (2H, m), 
               
               
                   
                 8.55 (1H, s). 
               
               
                 1-249 
                 1H-NMR (CDCl3) δ: 1.57 (6H, s), 3.77 (1H, d), 4.14-4.19 (3H, m), 4.36-4.39 (1H, m), 7.16 (1H, s), 7.28-7.29 (1H, m), 7.43-7.43 
               
               
                   
                 (1H, m), 7.51-7.51 (2H, m), 8.03-8.06 (1H, m), 8.11-8.11 (1H, m) 
               
               
                 1-250 
                 1H-NMR (CDCl3) δ: 3.04 (t, 2H), 3.54-3.64 (m, 2H), 3.72 (d, 1H), 4.10 (d, 1H), 6.18 (bs, 1H), 7.43 (s, 1H), 7.51 (s, 2H), 7.56 
               
               
                   
                 (d, 1H), 7.63 (s, 1H), 8.13 (d, 1H) 
               
               
                 1-251 
                 1H-NMR (CDCl3) δ: 2.67 (t, 2H), 3.01 (t, 2H), 3.67 (d, 1H), 4.06 (d, 1H), 6.85 (d, 1H), 7.38-7.60 (m, 5H), 8.91 (bs, 1H) 
               
               
                 1-252 
                 1H-NMR (CDCl3) δ: 1.81-1.93 (m, 2H), 2.72-2.85 (m, 4H), 3.68 (d, 1H), 4.08 (d, 1H), 4.56 (q, 2H), 7.40-7.56 (m, 5H), 8.00 (d, 1H) 
               
               
                 1-253 
                 1H-NMR (CDCl3) δ: 3.63 (1H, d), 4.03 (1H, d), 4.24-4.31 (4H, m), 6.89-6.92 (1H, m), 7.13-7.21 (2H, m), 7.41-7.41 (1H, m), 7.48-7.52 
               
               
                   
                 (2H, m). 
               
               
                 1-255 
                 1H-NMR (CDCl3) δ: 3.84 (1H, d), 4.22 (1H, d), 7.44 (1H, t), 7.54-7.54 (2H, m), 7.77 (1H, d), 8.00 (1H, d), 8.21 (1H, d Hz), 8.29-8.33 
               
               
                   
                 (2H, m). 
               
               
                 1-256 
                 1H-NMR (CDCl3) δ: 3.86 (d, 1H), 4.25 (d, 1H), 7.45 (s, 1H), 7.53-7.60 (m, 3H), 8.16 (d, 1H), 8.24-8.31 (m, 2H), 8.84 (d, 1H) 
               
               
                 1-257 
                 1H-NMR (CDCl3) δ: 3.83 (d, 1H), 4.21 (d, 1H), 7.32-7.49 (m, 2H), 7.54 (s, 2H), 7.74 (d, 1H), 8.03 (s, 1H), 8.15 (d, 1H), 8.56 
               
               
                   
                 (d, 1H), 8.79 (d, 1H) 
               
               
                 1-259 
                 1H-NMR (CDCl3) δ: 2.78 (3H, s), 3.81 (1H, d), 4.18 (1H, d), 7.44-7.52 (3H, m), 7.98-7.98 (1H, m), 8.08-8.11 (1H, m), 8.27 (1H, s), 
               
               
                   
                 8.52 (1H, d) 
               
               
                 1-260 
                 1H-NMR (CDCl3) δ: 3.80 (1H, d), 4.18 (1H), 5.56 (2H, s), 7.18-7.20 (1H, m), 7.33 (1H, d), 7.44-7.44 (1H, m), 7.52-7.52 (2H, m), 
               
               
                   
                 7.64-7.67 (1H, m), 7.94 (1H, s), 8.06-8.09 (1H, m), 8.23 (1H, s), 8.48 (1H, d), 8.56-8.58 (1H, m) 
               
               
                 1-269 
                 1H-NMR (CDCl3) δ: 3.77 (1H, d), 4.16 (1H, d), 4.94 (2H, s), 7.45 (1H, s), 7.52 (2H, s), 7.64-7.82 (3H, m), 7.92-8.11 (4H, m). 
               
               
                 1-270 
                 1H-NMR (CDCl3) δ: 3.77 (1H, d), 4.16 (1H, d), 4.94 (2H, s), 7.38-7.65 (5H, m), 7.75 (1H, d), 7.94-8.03 (2H, m), 8.09-8.20 (2H, m). 
               
               
                 1-271 
                 1H-NMR (CDCl3) δ: 3.76 (d, 1H), 3.94 (td, 2H), 4.14 (d, 1H), 4.59 (s, 2H), 4.70 (td, 2H), 7.44 (t, 1H), 7.52 (d, 1H), 7.71 (d, 1H), 
               
               
                   
                 7.85 (s, 1H), 7.91 (d, 1H) 
               
               
                 1-272 
                 1H-NMR (CDCl3) δ: 3.75 (d, 1H), 4.13 (d, 1H), 4.28 (t, 2H), 4.02 (s, 2H), 7.43 (t, 1H), 7.51 (d, 1H), 7.73 (d, 1H), 7.88 (s, 1H), 
               
               
                   
                 7.95 (d, 1H) 
               
               
                 1-295 
                 1H-NMR (CDCl3) δ: 3.82 (1H, d), 4.21 (1H, d), 7.62-7.39 (4H, m), 8.25-7.93 (4H, m). 
               
               
                 3-1 
                 1H-NMR (CDCl3) δ: 1.64-1.80 (m, 1H), 2.10 (bs, 2H), 2.47-2.61 (m, 1H), 2.75-2.90 (m, 1H), 2.90-3.05 (m, 1H), 3.69 (d, 1H), 4.08 
               
               
                   
                 (d, 1H), 4.38 (t, 1H), 7.35-7.44 (m, 2H), 7.46-7.57 (m, 4H) 
               
               
                 3-3 
                 1H-NMR (CDCl3) δ: 1.74-1.91 (m, 1H), 2.06 (s, 3H), 2.57-2.70 (m, 1H), 2.82-3.07 (m, 2H), 3.69 (d, 1H), 4.07 (d, 1H), 5.52 (q, 1H), 
               
               
                   
                 5.60-5.67 (d, 1H), 7.34 (d, 1H), 7.40-7.61 (m, 5H) 
               
               
                 3-4 
                 1H-NMR (CDCl3) δ: 1.21 (t, 3H), 1.71-1.88 (m, 1H), 2.27 (q, 2H), 2.55-2.70 (m, 1H), 2.80-3.06 (m, 2H), 3.69 (d, 1H), 4.08 (d, 1H), 
               
               
                   
                 5.52 (q, 1H), 5.63 (d, 1H), 7.28-7.61 (m, 6H) 
               
               
                 3-6 
                 1H-NMR (CDCl3) δ: 1.77-1.93 (m, 1H), 2.57-2.73 (m, 1H), 2.76-3.04 (m, 1H), 3.13 (q, 1H), 3.68 (d, 1H), 4.07 (d, 1H), 5.52 (q, 1H), 
               
               
                   
                 6.00 (m, 1H), 7.30 (d, 1H), 7.39-7.61 (m, 5H) 
               
               
                 3-7 
                 1H-NMR (CDCl3) δ: 0.72-0.85 (m, 2H), 0.98-1.10 (m, 2H), 1.30-1.42 (m, 1H), 1.75-1.92 (m, 1H), 2.55-2.71 (m, 1H), 2.80-3.07 (m, 2H), 
               
               
                   
                 3.69 (d, 1H), 4.08 (d, 1H), 5.53 (q, 1H), 5.83 (d, 1H), 7.32-7.63 (m, 6H) 
               
               
                 3-8 
                 1H-NMR (CDCl3) δ: 1.67-1.85 (m, 1H), 2.54-2.67 (m, 1H), 2.73-3.01 (m, 5H), 3.69 (d, 1H), 4.07 (d, 1H), 4.37-4.49 (m, 1H), 4.55-4.65 
               
               
                   
                 (m, 1H), 5.24-5.38 (m, 1H), 7.29-7.57 (m, 6H) 
               
               
                 3-9 
                 1H-NMR (CDCl3) δ: 1.16 (t, 3H), 1.69-1.84 (m, 1H), 2.55-2.67 (m, 1H), 2.75-3.02 (m, 2H), 3.24 (quintet, 1H), 3.68 (d, 1H), 4.07 
               
               
                   
                 (d, 1H), 4.37 (bs, 1H), 4.49-4.57 (m, 1H), 5.33 (q, 1H), 7.35 (d, 1H), 7.40-7.57 (m, 5H) 
               
               
                 3-23 
                 1H-NMR (CDCl3) δ: 1.81-1.98 (m, 1H), 2.67-2.81 (m, 1H), 2.82-2.98 (m, 2H), 3.00 (s, 3H), 3.69 (d, 1H), 5.85 (bs, 1H), 5.91 (bs, 1H), 
               
               
                   
                 6.10 (bs, 1H), 7.39-7.60 (m, 6H) 
               
               
                 3-32 
                 1H-NMR (CDCl3) δ: 1.81-1.97 (m, 1H), 2.63-2.77 (m, 1H), 2.81-3.07 (q, 2H), 3.54-3.87 (m, 4H), 4.06 (d, 1H), 4.70 (t, 2H), 5.86 
               
               
                   
                 (bs, 1H), 6.62 (bs, 1H), 6.83 (bs, 1H), 7.39-7.58 (m, 6H) 
               
               
                 3-33 
                 1H-NMR (CDCl3) δ: 2.42-2.66 (m, 2H), 2.95-3.09 (m, 1H), 3.31-3.43 (m, 1H), 3.68 (d, 1H), 4.07 (m, 1H), 5.89 (t, 1H), 7.15 (s, 1H), 
               
               
                   
                 7.42 (s, 1H), 7.45 (d, 1H), 7.50 (s, 2H), 7.61 (d, 1H), 7.70-7.78 (m, 2H), 7.80-7.90 (m, 2H) 
               
               
                 3-34 
                 1H-NMR (CDCl3) δ: 1.90-2.03 (m, 1H), 2.48-2.60 (m, 1H), 2.48-2.60 (m, 1H), 2.77-2.90 (m, 1H), 3.00-3.13 (m, 1H), 3.70 (d, 1H), 4.09 
               
               
                   
                 (d, 1H), 5.27 (t, 1H), 7.40-7.59 (m, 6H) 
               
               
                 3-39 
                 1H-NMR (CDCl3) δ: 1.74-1.89 (m, 1H), 2.07 (s, 3H), 2.55-2.70 (m, 1H), 2.79-3.07 (m, 2H), 3.68 (d, 1H), 4.08 (d, 1H), 5.51 (q, 1H), 
               
               
                   
                 5.61-5.74 (m, 1H), 7.30-7.60 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-40 
                 1H-NMR (CDCl3) δ: 1.21 (t, 3H), 1.72-1.88 (m, 1H), 2.27 (q, 2H), 2.56-2.72 (m, 1H), 2.80-3.06 (m, 2H), 3.68 (d, 1H), 4.08 (d, 1H), 
               
               
                   
                 5.47-5.68 (m, 2H), 7.28-7.59 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-42 
                 1H-NMR (CDCl3) δ: 1.75-1.91 (m, 1H), 2.54-2.69 (m, 1H), 2.80-3.04 (m, 2H), 3.11 (q, 2H), 3.68 (d, 1H), 4.07 (d, 1H), 5.49 (q, 1H), 
               
               
                   
                 6.15-6.27 (m, 1H), 7.22-7.58 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-43 
                 1H-NMR (CDCl3) δ: 0.72-0.82 (m, 1H), 0.86-0.95 (m, 1H), 0.98-1.09 (m, 2H), 1.32-1.43 (m, 1H), 1.76-1.91 (m, 1H), 2.54-2.68 (m, 1H), 
               
               
                   
                 2.78-3.06 (m, 2H), 3.69 (s, 1H), 4.08 (s, 1H), 5.51 (q, 1H), 5.97 (d, 1H), 7.28-7.58 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-44 
                 1H-NMR (CDCl3) δ: 1.62-1.78 (m, 1H), 2.40-2.61 (m, 1H), 2.65-2.95 (m, 5H), 3.69 (d, 1H), 4.06 (d, 1H), 4.70-5.01 (m, 2H), 5.15-5.32 
               
               
                   
                 (m, 1H), 7.22-7.49M, 3H), 7.65 (s, 2H) 
               
               
                 3-45 
                 1H-NMR (CDCl3) δ: 1.10 (t, 3H), 1.56-1.76 (m, 1H), 2.43-2.57 (m, 1H), 2.64-2.92 (m, 2H), 3.18 (q, 2H), 3.70 (d, 1H), 4.06 (d, 1H), 
               
               
                   
                 4.81-4.92 (m, 1H), 5.02-5.31 (m, 2H), 7.19-7.45 (m, 3H), 7.65 (s, 2H) 
               
               
                 3-48 
                 1H-NMR (CDCl3) δ: 0.53-0.62 (m, 2H), 0.68-0.78 (m, 2H), 1.73-1.90 (m, 1H), 2.38-2.50 (m, 1H), 2.59-2.74 (m, 1H), 2.79-3.06 (m, 2H), 
               
               
                   
                 3.69 (d, 1H), 4.08 (d, 1H), 4.87 (bs, 1H), 5.20 (d, 1H), 5.42 (q, 1H), 7.32-7.58 (m, 3H), 7.65 (s, 2H) 
               
               
                 3-55 
                 1H-NMR (CDCl3) δ: 1.57-1.76 (m, 1H), 2.42-2.58 (m, 1H), 2.63-2.93 (m, 2H), 3.69 (d, 1H), 3.75-3.90 (m, 2H), 4.06 (d, 1H), 5.11-5.36 
               
               
                   
                 (m, 3H), 7.15-7.47 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-57 
                 1H-NMR (CDCl3) δ: 1.68-1.86 (m, 1H), 2.18-2.25 (m, 1H), 2.51-2.67 (m, 1H), 2.73-3.01 (m, 2H), 3.68 (d, 1H), 3.93-4.07 (m, 3H), 
               
               
                   
                 4.68-4.86 (m, 2H), 5.31 (q, 1H), 7.29-7.54 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-61 
                 1H-NMR (CDCl3) δ: 1.73-1.86 (m, 1H), 2.57-2.73 (m, 1H), 2.80-3.01 (m, 8H), 3.67 (d, 1H), 4.08 (d, 1H), 4.52 (d, 1H), 5.43 (q, 1H), 
               
               
                   
                 7.34-7.59 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-70 
                 1H-NMR (CDCl3) δ: 2.07 (s, 3H), 2.08-2.19 (m, 1H), 2.46-2.60 (m, 1H), 2.84-2.96 (m, 1H), 3.06-3.19 (m, 1H), 3.68 (d, 1H), 6.18 
               
               
                   
                 (dd, 1H), 7.46-7.52 (m, 2H), 7.60 (d, 1H), 7.64 (s, 2H) 
               
               
                 3-73 
                 1H-NMR (CDCl3) δ: 1.20 (t, 3H), 1.73-1.89 (m, 1H), 2.27 (q, 2H), 2.55-2.69 (m, 1H), 2.79-3.06 (m, 2H), 3.70 (d, 1H), 4.14 (d, 1H), 
               
               
                   
                 5.51 (q, 1H), 5.65-5.78 (m, 1H), 7.28-7.60 (m, 3H), 7.84 (s, 1H), 7.95 (s, 1H) 
               
               
                 3-74 
                 1H-NMR (CDCl3) δ: 1.77-1.93 (m, 1H), 2.57-2.75 (m, 1H), 2.82-3.23 (m, 4H), 3.70 (d, 1H), 4.13 (d, 1H), 5.53 (q, 1H), 5.89-6.09 
               
               
                   
                 (m, 1H), 7.26-7.64 (m, 3H), 7.84 (s, 1H), 7.95 (s, 1H) 
               
               
                 3-81 
                 1H-NMR (CDCl3) δ: 1.21 (t, 3H), 1.72-1.89 (m, 1H), 2.27 (q, 2H), 2.55-2.70 (m, 1H), 2.81-3.07 (m, 2H), 3.69 (d, 1H), 4.07 (d, 1H), 
               
               
                   
                 5.53 (q, 1H), 5.61-5.72 (m, 1H), 7.27-7.60 (m, 3H), 7.67-7.80 (m, 3H) 
               
               
                 3-82 
                 1H-NMR (CDCl3) δ: 1.93-2.10 (m, 1H), 2.64-3.11 (m, 3H), 3.69 (d, 1H), 4.08 (d, 1H), 4.87 (d, 1H), 5.12 (q, 1H), 6.28 (t, 1H), 
               
               
                   
                 7.45-7.74 (m, 5H) 
               
               
                 3-88 
                 1H-NMR (CDCl3) δ: 1.74-1.91 (m, 1H), 2.05 (s, 3H), 2.57-2.70 (m, 1H), 2.81-3.07 (m, 2H), 3.74 (d, 1H), 4.19 (d, 1H), 5.51 (q, 1H), 
               
               
                   
                 5.66-5.74 (m, 1H), 7.30-7.62 (m, 3H), 7.96 (s, 1H), 8.09 (s, 2H) 
               
               
                 3-89 
                 1H-NMR (CDCl3) δ: 1.20 (t, 3H), 1.72-1.89 (m, 1H), 2.27 (q, 1H), 2.55-2.70 (m, 1H), 2.81-3.06 (m, 2H), 3.75 (d, 1H), 4.20 (d, 1H), 
               
               
                   
                 5.52 (q, 1H), 5.72 (d, 1H), 7.28-7.62 (m, 3H), 7.96 (s, 1H), 8.09 (s, 2H) 
               
               
                 3-90 
                 1H-NMR (CDCl3) δ: 1.78-1.96 (m, 1H), 2.59-2.75 (m, 1H), 2.83-3.20 (m, 4H), 3.75 (d, 1H), 4.19 (d, 1H), 5.55 (q, 1H), 5.82-5.96 
               
               
                   
                 (m, 1H), 7.17-7.64 (m, 3H), 7.96 (s, 1H), 8.08 (s, 2H) 
               
               
                 3-91 
                 1H-NMR (CDCl3) δ: 0.73-0.83 (m, 1H), 0.87-0.97 (m, 1H), 1.00-1.10 (m, 2H), 1.30-1.40 (m, 1H), 1.76-1.91 (m, 1H), 2.58-2.70 (m, 1H), 
               
               
                   
                 2.81-3.07 (m, 2H), 3.74 (d, 1H), 4.19 (d, 1H), 5.54 (q, 1H), 5.73-5.84 (m, 1H), 7.32-7.61 (m, 3H), 7.96 (s, 1H), 8.09 (s, 2H) 
               
               
                 3-92 
                 1H-NMR (CDCl3) δ: 1.58-1.91 (m, 1H), 2.35-2.97 (m, 6H), 3.75 (s, 1H), 4.19 (d, 1H), 4.92-5.30 (m, 3H), 7.18-7.49 (m, 3H), 7.96 
               
               
                   
                 (s, 1H), 8.08 (s, 2H) 
               
               
                 3-93 
                 1H-NMR (CDCl3) δ: 1.16 (t, 3H), 1.70-1.86 (m, 1H), 2.55-2.71 (m, 1H), 2.77-3.02 (m, 2H), 3.24 (q, 2H), 3.74 (d, 1H), 4.19 (d, 1H), 
               
               
                   
                 4.27-4.36 (m, 1H), 4.43-4.52 (m, 1H), 5.35 (q, 1H), 7.34-7.70 (m, 3H), 7.96 (s, 1H), 8.09 (s, 2H) 
               
               
                 3-95 
                 1H-NMR (CDCl3) δ: 1.81-2.00 (m, 1H), 2.66-3.13 (m, 6H), 3.74 (d, 1H), 4.19 (d, 1H), 5.64-6.11 (m, 3H), 7.40-7.65 (m, 3H), 7.96 
               
               
                   
                 (s, 1H), 8.09 (s, 2H) 
               
               
                 3-97 
                 1H-NMR (CDCl3) δ: 1.20 (t, 3H), 1.72-1.88 (m, 1H), 2.27 (q, 2H), 2.54-2.70 (m, 1H), 2.80-3.07 (m, 2H), 3.72 (d, 1H), 4.14 (d, 1H), 
               
               
                   
                 5.52 (q, 1H), 5.63-5.75 (m, 1H), 7.28-7.59 (m, 3H), 7.68 (s, 1H), 7.76 (s, 1H), 7.82 (s, 1H) 
               
               
                 3-98 
                 1H-NMR (CDCl3) δ: 1.77-1.93 (m, 1H), 2.57-2.73 (m, 1H), 2.82-3.21 (m, 4H), 3.71 (d, 1H), 4.13 (d, 1H), 5.52 (q, 1H), 5.97-6.10 
               
               
                   
                 (m, 1H), 7.27-7.61 (m, 6H), 7.68 (s, 1H), 7.76 (s, 1H), 7.82 (s, 1H) 
               
               
                 3-104 
                 1H-NMR (CDCl3) δ: 1.85-1.95 (1H, m), 2.51-2.55 (1H, m), 2.82-3.46 (5H, m), 3.77 (1H, d), 4.36-4.52 (2H, m), 4.80-4.85 (1H, m), 
               
               
                   
                 7.24-7.28 (2H, m), 7.36-7.37 (1H, m), 7.45 (1H, d, J = 7.9 Hz), 7.69-7.72 (2H, m) 
               
               
                 3-106 
                 1H-NMR (CDCl3) δ: 1.82-1.86 (1H, m), 2.04 (3H, s), 2.61-2.65 (1H, m), 2.89-2.97 (2H, m), 3.44 (1H, d), 3.79 (1H, d), 4.42 (1H, d), 
               
               
                   
                 4.87 (1H, d), 5.50-5.53 (1H, m), 5.81-5.84 (1H, m), 7.29-7.34 (4H, m), 7.65-7.76 (2H, m) 
               
               
                 3-112 
                 1H-NMR (CDCl3) δ: 1.11 (3H, t), 1.65-1.82 (1H, m), 2.51-2.56 (1H, m), 2.77-2.89 (2H, m), 3.17-3.22 (2H, m), 3.42 (1H, d), 3.77 
               
               
                   
                 (1H, d), 4.40 (1H, d), 4.81-4.86 (2H, m), 4.98 (1H, d), 5.25-5.28 (1H, m), 7.27-7.37 (4H, m), 7.62-7.68 (2H, m) 
               
               
                 3-130 
                 1H-NMR (CDCl3) δ: 1.49 (9H, s), 1.78-1.88 (1H, m), 2.59-2.62 (1H, m), 2.80-3.02 (2H, m), 3.44 (1H, d), 3.79 (1H, d), 4.41 (1H, d), 
               
               
                   
                 4.83-4.89 (2H, m), 5.19-5.22 (1H, m), 7.26-7.29 (2H, m), 7.36-7.39 (2H, m), 7.66-7.73 (2H, m) 
               
               
                 3-137 
                 1H-NMR (CDCl3) δ: 1.89-2.06 (2H, m), 2.50-2.63 (1H, m), 2.81-2.91 (1H, m), 3.09-3.13 (1H, m), 3.44-3.47 (1H, m), 3.77-3.83 (1H, m), 
               
               
                   
                 4.43 (1H, d), 4.84-4.90 (1H, m), 5.28 (1H, br s), 7.23-7.29 (3H, m), 7.37-7.38 (1H, m), 7.49 (1H, d), 7.72-7.75 (2H, m) 
               
               
                 3-138 
                 1H-NMR (CDCl3) δ: 2.04-2.19 (4H, m), 2.53-2.57 (1H, m), 2.94-2.96 (1H, m), 3.11-3.16 (1H, m), 3.45 (1H, d), 3.80 (1H, d), 4.44 
               
               
                   
                 (1H, d), 4.85-4.91 (1H, m), 6.20-6.22 (1H, m), 7.26-7.27 (2H, m), 7.37-7.38 (1H, m), 7.48 (1H, d), 7.69-7.72 (1H, m), 7.79-7.80 
               
               
                 3-140 
                 1H-NMR (CDCl3) δ: 1.76-1.86 (1H, m), 2.38-2.58 (1H, m), 2.83-3.07 (2H, m), 3.43 (1H, d), 3.79 (1H, d), 4.41-4.43 (3H, m), 4.85 
               
               
                   
                 (1H, d), 7.40-7.44 (3H, m), 7.70-7.75 (2H, m) 
               
               
                 3-142 
                 1H-NMR (CDCl3) δ: 1.79-1.89 (1H, m), 2.05 (3H, s), 2.58-2.69 (1H, m), 2.90-3.01 (2H, m), 3.43 (1H, d), 3.79 (1H, d), 4.41 (1H, d), 
               
               
                   
                 4.86 (1H, dd), 5.51-5.53 (1H, m), 5.75-5.78 (1H, m), 7.36-7.39 (3H, m), 7.65-7.76 (2H, m) 
               
               
                 3-143 
                 1H-NMR (CDCl3) δ: 1.21 (3H, t), 1.79-1.89 (1H, m), 2.28 (2H, q), 2.63-2.68 (1H, m), 2.93-2.98 (2H, m), 3.44 (1H, d), 3.79 (1H, d), 
               
               
                   
                 4.42 (1H, d), 4.85-4.88 (1H, m), 5.54-5.56 (1H, m), 5.74-5.77 (1H, m), 7.35-7.39 (3H, m), 7.65-7.75 (2H, m) 
               
               
                 3-145 
                 1H-NMR (CDCl3) δ: 1.81-1.91 (1H, m), 2.61-2.64 (1H, m), 2.87-3.23 (4H, m), 3.46 (1H, d), 3.80 (1H, d), 4.43 (1H, d), 4.87 (1H, d), 
               
               
                   
                 5.48-5.51 (1H, m), 6.35-6.37 (2H, m), 7.31 (1H, d), 7.40 (2H, s), 7.63-7.73 (2H, m) 
               
               
                 3-166 
                 1H-NMR (CDCl3) δ: 1.50 (9H, s), 1.79-1.89 (1H, m), 2.61-2.63 (1H, m), 2.82-3.03 (2H, m), 3.43 (1H, d), 3.79 (1H, d), 4.42 (1H, d), 
               
               
                   
                 4.80-4.86 (2H, m), 5.21-5.23 (1H, m), 7.38-7.41 (3H, m), 7.69-7.72 (2H, m) 
               
               
                 3-188 
                 1H-NMR (CDCl3) δ: 1.83-1.88 (1H, m), 2.06 (3H, s), 2.63-2.67 (1H, m), 2.86-3.07 (2H, m), 3.49-3.53 (1H, m), 3.91 (1H, d), 4.50 
               
               
                   
                 (1H, d), 4.98-5.01 (1H, m), 5.52-5.55 (1H, m), 5.67-5.70 (1H, m), 7.38 (1H, d), 7.69-7.91 (5H, m) 
               
               
                 3-191 
                 1H-NMR (CDCl3) δ: 0.81-0.91 (4H, m), 1.23-1.41 (1H, m), 1.83-1.89 (1H, m), 2.61-2.69 (1H, m), 2.92-3.00 (2H, m), 3.51 (1H, d), 3.91 
               
               
                   
                 (1H, d), 4.50 (1H, d), 4.99 (1H, d), 5.52-5.62 (1H, m), 5.85-5.88 (1H, m), 7.39 (1H, d), 7.69-7.91 (5H, m) 
               
               
                 3-211 
                 1H-NMR (CDCl3) δ: 1.47-2.11 (m, 6H), 2.68-2.90 (m, 2H), 3.68 (d, 1H), 3.98 (t, 1H), 4.07 (d, 1H), 7.37 (s, 1H), 7.42 (t, 1H), 7.48 
               
               
                   
                 (s, 2H), 7.51 (s, 2H) 
               
               
                 3-213 
                 1H-NMR (CDCl3) δ: 1.71-1.92 (m, 3H), 1.99-2.13 (m, 4H), 2.70-2.89 (m, 2H), 3.67 (d, 1H), 4.06 (d, 1H), 5.16-5.28 (m, 1H), 5.68 
               
               
                   
                 (d, 1H), 7.31-7.54 (m, 6H) 
               
               
                 3-216 
                 1H-NMR (CDCl3) δ: 1.76-1.94 (m, 3H), 2.06-2.19 (m, 1H), 3.67 (d, 1H), 4.06 (d, 1H), 4.13 (s, 2H), 5.16-5.27 (m, 1H), 6.74 (d, 1H), 
               
               
                   
                 7.29-7.53 (m, 6H) 
               
               
                 3-217 
                 1H-NMR (CDCl3) δ: 1.73-1.93 (m, 3H), 2.01-2.18 (m, 1H), 2.69-2.89 (m, 2H), 3.11 (q, 2H), 3.67 (d, 1H), 4.05 (d, 1H), 5.16-5.28 
               
               
                   
                 (m, 1H), 5.99 (d, 1H), 7.22-7.56 (m, 6H) 
               
               
                 3-218 
                 1H-NMR (CDCl3) δ: 0.71-0.83 (m, 2H), 0.97-1.09 (m, 2H), 1.28-1.39 (m, 1H), 1.71-1.92 (m, 3H), 1.99-2.16 (m, 1H), 2.70-2.90 (m, 2H), 
               
               
                   
                 3.67 (d, 1H), 4.06 (d, 1H), 5.16-5.28 (m, 1H), 5.84 (d, 1H), 7.31-7.55 (m, 6H) 
               
               
                 3-219 
                 1H-NMR (CDCl3) δ: 1.85-1.99 (m, 3H), 2.10-2.27 (m, 1H), 2.76-2.91 (m, 2H), 3.68 (d, 1H), 4.07 (d, 1H), 5.37-5.50 (m, 1H), 6.32 
               
               
                   
                 (d, 1H), 7.36-7.61 (m, 9H), 7.80 (d, 2H) 
               
               
                 3-220 
                 1H-NMR (CDCl3) δ: 1.71-1.91 (m, 3H), 2.01-2.13 (m, 1H), 2.70-2.88 (m, 5H), 3.67 (d, 1H), 4.06 (d, 1H), 4.24-4.36 (m, 1H), 4.49 
               
               
                   
                 (d, 1H), 4.95-5.08 (m, 1H), 7.32-7.56 (m, 6H) 
               
               
                 3-221 
                 1H-NMR (CDCl3) δ: 1.16 (t, 3H), 1.69-1.91 (m, 3H), 2.03-2.14 (m, 1H), 2.71-2.83 (m, 2H), 3.23 (q, 2H), 3.66 (d, 1H), 4.06 (d, 1H), 
               
               
                   
                 4.21-4.29 (m, 1H), 4.43 (d, 1H), 4.97-5.07 (m, 1H), 7.32-7.54 (m, 6H) 
               
               
                 3-230 
                 1H-NMR (CDCl3) δ: 1.69-1.91 (m, 3H), 1.99-2.14 (m, 1H), 2.71-2.84 (m, 2H), 3.52-3.71 (m, 5H), 4.06 (d, 1H), 4.60 (d, 1H), 4.71-4.80 
               
               
                   
                 (m, 1H), 4.94-5.5 (m, 1H), 7.32-7.46 (m, 4H), 7.51 (s, 2H) 
               
               
                 3-235 
                 1H-NMR (CDCl3) δ: 0.60-0.85 (m, 4H), 1.81-1.96 (m, 3H), 2.18-2.31 (m, 1H), 2.38-2.49 (m, 1H), 2.75-2.93 (m, 2H), 3.68 (d, 1H), 4.07 
               
               
                   
                 (d, 1H), 5.75-5.86 (m, 1H), 6.33-6.44 (m, 2H), 7.39-7.59 (m, 6H) 
               
               
                 3-236 
                 1H-NMR (CDCl3) δ: 1.79-1.93 (m, 3H), 2.12-2.27 (m, 1H), 2.74-2.86 (m, 1H), 2.96 (s, 3H), 3.67 (d, 1H), 4.06 (d, 1H), 5.67 (bs, 1H), 
               
               
                   
                 5.81 (bs, 1H), 6.12 (bs, 1H), 7.35-7.54 (m, 6H) 
               
               
                 3-238 
                 1H-NMR (CDCl3) δ: 1.71-1.92 (m, 3H), 1.98-2.14 (m, 1H), 2.72-2.84 (m, 2H), 2.92 (s, 6H), 3.68 (d, 1H), 4.06 (d, 1H), 4.56 (d, 1H), 
               
               
                   
                 5.03-5.15 (m, 1H), 7.33-7.56 (m, 6H) 
               
               
                 3-239 
                 1H-NMR (CDCl3) δ: 1.75-1.91 (m, 3H), 2.03-2.14 (m, 1H), 2.71-2.85 (m, 2H), 3.66 (d, 1H), 3.72 (s, 3H), 4.06 (d, 1H), 4.90 (s, 2H), 
               
               
                   
                 7.34-7.54 (m, 6H) 
               
               
                 3-241 
                 1H-NMR (CDCl3) δ: 1.79-1.98 (m, 3H), 2.06-2.25 (m, 1H), 2.70-2.90 (m, 2H), 3.08 (s, 3H), 3.67 (d, 1H), 4.06 (d, 1H), 4.50 (d, 1H), 
               
               
                   
                 4.62-4.75 (m, 1H), 7.36-7.61 (m, 6H) 
               
               
                 3-251 
                 1H-NMR (CDCl3) δ: 1.48-2.11 (m, 6H), 2.66-2.90 (m, 2H), 3.67 (d, 1H), 3.98 (t, 1H), 4.08 (d, 1H), 7.37 (s, 1H), 7.48 (s, 2H), 7.65 
               
               
                   
                 (s, 2H) 
               
               
                 3-253 
               
               
                 3-254 
                 1H-NMR (CDCl3) δ: 1.20 (t, 3H), 1.68-1.93 (m, 3H), 2.00-2.13 (m, 1H), 2.26 (q, 2H), 2.70-2.91 (m, 2H), 3.66 (d, 1H), 4.06 (d, 1H), 
               
               
                   
                 5.15-5.29 (m, 1H), 5.58-5.70 (m, 1H), 7.28-7.50 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-256 
                 1H-NMR (CDCl3) δ: 1.80-1.87 (3H, m), 2.05-2.13 (1H, m), 2.80-2.82 (2H, m), 3.11 (2H, q), 3.66 (1H, d), 4.06 (2H, dd), 5.21-5.26 
               
               
                   
                 (1H, m), 5.95 (1H, d), 7.30 (1H, d), 7.39-7.51 (2H, m), 7.64 (2H, s) 
               
               
                 3-257 
                 1H-NMR (CDCl3) δ: 0.70-0.83 (m, 2H), 0.94-1.12 (m, 2H), 1.27-1.40 (m, 1H), 1.70-1.93 (m, 3H), 1.99-2.14 (m, 1H), 2.67-2.92 (m, 2H), 
               
               
                   
                 3.66 (d, 1H), 4.06 (d, 1H), 5.15-5.29 (m, 1H), 5.84 (d, 1H), 7.31-7.54 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-258 
                 1H-NMR (CDCl3) δ: 1.63-1.87 (m, 3H), 1.95-2.10 (m, 1H), 2.64-2.86 (m, 5H), 3.66 (d, 1H), 4.05 (d, 1H), 4.48-4.58 (m, 1H), 4.66-4.77 
               
               
                   
                 (m, 1H), 4.92-5.04 (m, 1H), 7.27-7.48 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-259 
                 1H-NMR (CDCl3) δ: 1.13 (t, 3H), 1.65-1.88 (m, 3H), 1.95-2.12 (m, 1H), 2.63-2.85 (m, 2H), 3.11-3.28 (m, 2H), 3.66 (d, 1H), 4.06 
               
               
                   
                 (d, 1H), 4.43-4.53 (m, 1H), 4.63-4.74 (m, 1H), 4.91-5.04 (m, 1H), 7.26-7.46 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-261 
                 1H-NMR (CDCl3) δ: 1.09-1.19 (m, 6H), 1.65-1.88 (m, 3H), 2.00-2.13 (m, 1H), 2.66-2.81 (m, 2H), 3.65 (d, 1H), 3.78-3.93 (m, 1H), 4.05 
               
               
                   
                 (d, 1H), 4.24 (d, 1H), 4.53 (d, 1H), 4.91-5.05 (m, 1H), 7.28-7.46 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-270 
                 1H-NMR (CDCl3) δ: 1.65-1.88 (m, 3H), 1.96-2.10 (m, 1H), 2.65-2.83 (m, 2H), 3.66 (d, 1H), 3.73-3.84 (m, 2H), 4.05 (d, 1H), 4.57-4.70 
               
               
                   
                 (m, 1H), 4.73-4.83 (m, 1H), 4.91-5.03 (m, 1H), 5.05-5.24 (m, 2H), 5.75-5.93 (m, 1H), 7.27-7.46 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-284 
                 1H-NMR (CDCl3) δ: 1.76-2.19 (m, 7H), 2.65-2.95 (m, 2H), 3.67 (d, 1H), 4.07 (d, 1H), 5.95-6.03 (m, 1H), 7.30-7.52 (m, 3H), 7.64 
               
               
                   
                 (s, 2H) 
               
               
                 3-302 
                 1H-NMR (CDCl3) δ: 1.67-1.93 (m, 3H), 1.99-2.14 (m, 4H), 2.72-2.90 (m, 2H), 3.72 (d, 1H), 4.17 (d, 1H), 5.16-5.28 (m, 1H), 5.64 
               
               
                   
                 (d, 1H), 7.31-7.53 (m, 3H), 7.96 (s, 1H), 8.08 (s, 2H) 
               
               
                 3-303 
                 1H-NMR (CDCl3) δ: 1.20 (t, 3H), 1.68-1.92 (m, 3H), 1.99-2.14 (m, 1H), 2.26 (q, 2H), 2.69-2.90 (m, 2H), 3.72 (d, 1H), 4.18 (d, 1H), 
               
               
                   
                 5.15-5.28 (m, 1H), 5.56-5.69 (m, 1H), 7.29-7.53 (m, 3H), 7.96 (s, 1H), 8.08 (s, 2H) 
               
               
                 3-304 
                 1H-NMR (CDCl3) δ: 1.72-1.92 (m, 3H), 1.98-2.17 (m, 1H), 2.70-2.89 (m, 2H), 3.11 (q, 2H), 3.72 (d, 1H), 4.17 (d, 1H), 5.16-5.29 
               
               
                   
                 (m, 1H), 5.92-6.06 (m, 1H), 7.25-7.52 (m, 3H), 7.96 (s, 1H), 8.08 (s, 2H) 
               
               
                 3-305 
                 1H-NMR (CDCl3) δ: 0.70-0.84 (m, 2H), 0.96-1.11 (m, 2H), 1.28-1.39 (m, 1H), 1.72-1.93 (m, 3H), 2.01-2.15 (m, 1H), 2.68-2.93 (m, 2H), 
               
               
                   
                 3.72 (d, 1H), 4.17 (d, 1H), 5.17-5.29 (m, 1H), 5.82 (d, 1H), 7.32-7.54 (m, 3H), 7.96 (s, 1H), 8.09 (s, 2H) 
               
               
                 3-306 
                 1H-NMR (CDCl3) δ: 1.62-1.90 (m, 3H), 1.98-2.11 (m, 1H), 2.68-2.87 (m, 5H), 3.72 (d, 1H), 4.19 (d, 1H), 4.37-4.52 (m, 1H), 4.63 
               
               
                   
                 (d, 1H), 4.91-5.08 (m, 1H), 7.28-7.51 (m, 3H), 7.96 (s, 1H), 8.08 (s, 2H) 
               
               
                 3-307 
                 1H-NMR (CDCl3) δ: 1.14 (t, 3H), 1.54-1.87 (m, 3H), 1.98-2.13 (m, 1H), 2.68-2.86 (m, 2H), 3.14-3.30 (m, 2H), 3.72 (d, 1H), 4.18 
               
               
                   
                 (d, 1H), 4.27-4.65 (m, 2H), 4.94-5.09 (m, 1H), 7.29-7.52 (m, 3H), 7.96 (s, 1H), 8.08 (s, 2H) 
               
               
                 3-318 
                 1H-NMR (CDCl3) δ: 1.91-2.10 (4H, m), 2.80-2.86 (2H, m), 3.40 (1H, d), 3.72 (1H, d), 4.32-4.36 (2H, m), 4.78 (1H, d), 7.27-7.45 
               
               
                   
                 (4H, m), 7.58-7.61 (2H, m). 
               
               
                 3-320 
                 1H-NMR (CDCl3) δ: 1.66-1.70 (2H, m), 1.78-1.90 (2H, m), 2.08 (3H, s), 2.82-2.84 (2H, m), 3.42 (1H, d), 3.77 (1H, d), 4.42 (1H, d), 
               
               
                   
                 4.86 (1H, d), 5.21-5.24 (1H, m), 5.72 (1H, d), 7.26-7.38 (4H, m), 7.59-7.63 (2H, m). 
               
               
                 3-322 
                 1H-NMR (CDCl3) δ: 1.90-1.92 (3H, m), 2.12-2.17 (1H, m), 2.87-2.89 (2H, m), 3.43 (1H, d), 3.77 (1H, d), 4.43 (1H, d), 4.88 (1H, d), 
               
               
                   
                 5.26-5.29 (1H, m), 6.46 (1H, d), 7.28-7.36 (4H, m), 7.65-7.67 (2H, m). 
               
               
                 3-323 
                 1H-NMR (CDCl3) δ: 1.84-1.87 (2H, m), 2.07-2.14 (2H, m), 2.84-2.86 (2H, m), 3.12 (2H, q), 3.43 (1H, d), 3.77 (1H, d), 4.42 (1H, d), 
               
               
                   
                 4.87 (1H, d), 5.25-5.28 (1H, m), 5.93 (1H, d), 7.29-7.36 (4H, m), 7.62-7.65 (2H, m). 
               
               
                 3-326 
                 1H-NMR (CDCl3) δ: 1.13 (3H, t), 1.71-2.06 (3H, m), 2.79 (2H, s), 3.21 (2H, q), 3.41 (1H, d), 3.76 (1H, d), 4.40 (1H, d), 4.47-4.49 
               
               
                   
                 (1H, m), 4.71 (1H, d), 4.85 (1H, d), 5.00 (1H, d), 7.31-7.38 (4H, m), 7.54-7.58 (2H, m). 
               
               
                 3-344 
                 1H-NMR (CDCl3) δ: 1.23-1.28 (2H, m), 1.46 (9H, s), 1.82-1.84 (2H, m), 2.79-2.81 (2H, m), 3.42 (1H, d), 3.77 (1H, d), 4.41 (1H, d), 
               
               
                   
                 4.81-4.87 (3H, m), 7.31-7.39 (4H, m), 7.57-7.64 (2H, m). 
               
               
                 3-355 
                 1H-NMR (CDCl3) δ: 1.79-1.87 (4H, m), 2.05 (3H, s), 2.82-2.84 (2H, m), 3.41 (1H, d), 3.77 (1H, d), 4.41 (1H, d), 4.85 (1H, d), 
               
               
                   
                 5.22-5.24 (1H, m), 5.74 (1H, d), 7.36-7.39 (3H, m), 7.59-7.63 (2H, m). 
               
               
                 3-358 
                 1H-NMR (CDCl3) δ: 1.83-1.87 (4H, m), 2.83-2.84 (2H, m), 3.12 (2H, q), 3.41 (1H, d), 3.77 (1H, d), 4.41 (1H, d), 4.86 (1H, d), 
               
               
                   
                 5.25-5.27 (1H, m), 5.96 (1H, d), 7.33-7.38 (3H, m), 7.61-7.64 (2H, m). 
               
               
                 3-361 
                 1H-NMR (CDCl3) δ: 1.11 (3H, t), 1.72-1.80 (4H, m), 2.74-2.76 (2H, m), 3.16-3.21 (2H, m), 3.39 (1H, d), 3.75 (1H, d), 4.39 (1H, d), 
               
               
                   
                 4.62-4.63 (1H, m), 4.82-4.85 (2H, m), 4.96-4.99 (1H, m), 7.39-7.41 (3H, m), 7.51-7.60 (2H, m). 
               
               
                 3-922 
                 1H-NMR (CDCl3) δ: 1.49 (9H, s), 1.79-1.84 (4H, m), 2.80-2.82 (2H, m), 3.42 (1H, d), 3.78 (1H, d), 4.41 (1H, d), 4.84-4.87 (3H, m), 
               
               
                   
                 7.41-7.45 (3H, m), 7.57-7.64 (2H, m). 
               
               
                 3-547 
                 1H-NMR (CDCl3) δ: 1.04-1.29 (3H, m), 2.38 (2H, q), 3.56 (1H, d), 3.94 (1H, d), 4.49 (1H, d), 4.94 (1H, d), 7.48-7.58 (4H, m), 
               
               
                   
                 7.74-7.76 (1H, m), 7.89-7.94 (2H, m), 8.10-8.14 (2H, m). 
               
               
                 3-549 
                 1H-NMR (CDCl3) δ: 0.92-0.95 (2H, m), 1.12-1.17 (2H, m), 1.67-1.70 (1H, m), 3.55 (1H, d), 3.93 (1H, d), 4.48 (1H, d), 4.94 (1H, d), 
               
               
                   
                 7.46-7.51 (4H, m), 7.71-7.74 (1H, m), 7.94-7.99 (2H, m), 8.09-8.12 (2H, m). 
               
               
                 3-551 
                 1H-NMR (CDCl3) δ: 1.07-1.13 (3H, m), 3.26-3.30 (2H, m), 3.55 (1H, d), 3.92 (1H, d), 4.47 (1H, d), 4.83-4.86 (1H, m), 4.93 (1H, d), 
               
               
                   
                 6.78 (1H, s), 7.44 (2H, s), 7.51 (1H, t), 7.66 (1H, d), 7.77 (1H, d), 8.06 (2H, s), 8.17 (1H, s). 
               
               
                 3-635 
                 1H-NMR (CDCl3) δ: 3.14 (t, 2H), 3.67 (d, 1H), 3.85 (s, 3H), 3.99-4.12 (m, 3H), 7.33-7.44 (m, 2H), 7.51 (s, 2H), 7.58 (s, 1H), 7.97 
               
               
                   
                 (m, 1H) 
               
               
                 3-636 
                 1H-NMR (CDCl3) δ: 1.57 (s, 9H), 3.11 (t, 2H), 3.67 (d, 1H), 3.94-4.06 (m, 3H), 7.30-7.59 (m, 6H) 
               
               
                 3-637 
                 1H-NMR (acetone-d6) δ: 2.78 (3H, d,), 3.19 (2H, t), 4.00 (2H, t), 4.14 (1H, d), 4.31 (1H, d), 6.05 (1H, br s), 7.46 (1H, dd), 
               
               
                   
                 7.56-7.56 (1H, m), 7.61 (1H, t), 7.66 (2H, t), 8.01 (1H, d). 
               
               
                 3-638 
                 1H-NMR (CDCl3) δ: 1.22 (t, 3H), 3.20 (t, 2H), 3.39 (quintet, 2H), 3.68 (d, 1H), 3.93 (t, 2H), 4.07 (d, 1H), 4.57-4.66 (m, 1H), 7.31 
               
               
                   
                 (d, 1H), 7.41 (s, 1H), 7.51 (s, 2H), 7.58 (s, 1H), 7.98 (d, 1H) 
               
               
                 3-640 
                 1H-NMR (CDCl3) δ: 1.23 (d, 6H), 3.20 (t, 2H), 3.68 (d, 1H), 3.92 (t, 2H), 4.01-4.15 (m, 2H), 4.40 (d, 1H), 7.30 (d, 1H), 7.41 
               
               
                   
                 (s, 1H), 7.51 (s, 2H), 7.57 (s, 1H), 7.97 (d, 1H) 
               
               
                 3-641 
                 1H-NMR (CDCl3) δ: 0.54-0.60 (2H, m), 0.81-0.83 (2H, m), 2.71-2.75 (1H, m), 3.20 (2H, t), 3.67 (1H, d), 3.88 (2H), 4.07 (1H, d), 
               
               
                   
                 4.85 (1H, s), 7.31 (1H, dd), 7.41 (1H, t), 7.51 (2H, d), 7.58 (1H, d), 8.00 (1H, d). 
               
               
                 3-642 
                 1H-NMR (CDCl3) δ: 0.22-0.27 (2H, m), 0.51-0.57 (2H, m), 1.02-1.03 (1H, m), 3.19-3.23 (4H, m), 3.67 (1H, d), 3.97 (2H, t,), 4.07 
               
               
                   
                 (1H, d), 4.71 (1H, t), 7.31 (1H, dd), 7.41 (1H, t), 7.51-7.51 (2H, m), 7.58-7.58 (1H, m), 7.97 (1H, d). 
               
               
                 3-643 
                 1H-NMR (CDCl3) δ: 3.26 (3H, t), 3.68 (1H, d), 4.01-4.07 (6H, m), 4.89 (1H, t), 7.34 (1H, dd), 7.41-7.42 (1H, m), 7.51-7.51 (2H, m), 
               
               
                   
                 7.61 (1H, d), 7.96 (1H, d). 
               
               
                 3-644 
                 1H-NMR (CDCl3) δ: 3.23 (2H, t), 3.68 (1H, d), 4.06-4.11 (3H, m), 4.64 (2H, t), 6.21 (1H, d), 7.22 (1H, dd), 7.32-7.33 (2H, m), 7.41 
               
               
                   
                 (1H, t), 7.52-7.52 (2H, m), 7.59-7.59 (1H, m), 7.69 (1H, td), 8.01 (1H, d), 8.55 (1H, dd). 
               
               
                 3-645 
                 1H-NMR (CDCl3) δ: 3.22 (t, 2H), 3.67 (d, 1H), 3.91-4.02 (m, 4H), 4.07 (d, 1H), 4.64-4.67 (m, 1H), 5.12-5.32 (m, 2H), 5.85-6.01 
               
               
                   
                 (m, 1H), 7.31 (d, 1H), 7.41 (s, 1H), 7.51 (s, 2H), 7.59 (s, 1H), 7.98 (d, 1H) 
               
               
                 3-646 
                 1H-NMR (CDCl3) δ: 2.27 (1H, t), 3.22 (2H, t), 3.68 (1H, d), 3.97 (2H, t), 4.04-4.16 (3H, m), 4.82 (1H, t), 7.32 (1H, dd), 7.41 
               
               
                   
                 (1H, t), 7.51-7.51 (2H, m), 7.59-7.59 (1H, m), 7.98 (1H, d). 
               
               
                 3-647 
                 1H-NMR (acetone-d6) δ: 3.34 (2H, t), 4.18 (1H, d), 4.34-4.36 (3H, m), 7.12-7.14 (1H), 7.31-7.36 (1H), 7.44-7.47 (1H), 7.53-7.56 (1H), 
               
               
                   
                 7.62-7.65 (4H), 8.03-8.05 (1H, d), 8.13-8.15 (1H). 
               
               
                 3-648 
                 1H-NMR (acetone-d6) δ: 3.28 (2H, t), 4.17 (1H, d), 4.24-4.37 (3H, m), 6.99-7.84 (14H, m), 8.05 (1H, d). 
               
               
                 3-649 
                 1H-NMR (acetone-d6) δ: 3.28 (2H, t), 4.17 (1H, d), 4.27 (2H, t), 4.34 (0H, d), 7.12-7.32 (5H, m), 7.56-7.61 (4H, m), 8.05 (1H, d), 
               
               
                   
                 8.11 (1H, s) 
               
               
                 3-650 
                 1H-NMR (CDCl3) δ: 3.22 (3H, t), 3.67 (1H, d), 3.96 (2H, t), 4.07 (1H, d), 4.50 (2H, d), 4.92 (1H, t), 7.26-7.34 (5H, m), 7.41 
               
               
                   
                 (1H, t), 7.51-7.52 (2H, m), 7.59-7.60 (1H, m), 7.99 (1H, d). 
               
               
                 3-651 
                 1H-NMR (CDCl3) δ: 2.95 (s, 6H), 3.06 (t, 2H), 3.66 (d, 1H), 3.95 (t, 2H), 4.06 (d, 1H), 6.94 (d, 1H), 7.36 (d, 1H), 7.41 (s, 1H), 
               
               
                   
                 7.51 (s, 2H), 7.54 (s, 1H) 
               
               
                 3-652 
                 1H-NMR (CDCl3) δ: 3.13 (t, 2H), 3.24 (s, 3H), 3.67 (d, 1H), 4.06 (d, 1H), 4.32 (t, 2H), 6.05-6.17 (m, 1H), 7.34-7.44 (m, 2H), 7.51 
               
               
                   
                 (s, 2H), 7.61 (s, 1H), 8.08 (d, 1H) 
               
               
                 3-656 
                 1H-NMR (CDCl3) δ: 1.15 (3H, t), 1.89-1.98 (2H, m), 2.76 (2H, t), 3.28-3.38 (2H, m), 3.64-3.75 (3H, m), 4.06 (1H, d), 5.02 (1H, t), 
               
               
                   
                 7.44-7.48 (7H, m). 
               
               
                 3-659 
                 1H-NMR (CDCl3) δ: 0.50-0.52 (2H), 0.75-0.77 (2H), 1.92-1.95 (2H), 2.70-2.77 (3H, m), 3.63-3.74 (3H, m), 4.06 (1H, dz), 5.22 (1H, s), 
               
               
                   
                 7.35-7.51 (6H, m). 
               
               
                 3-660 
                 1H-NMR (CDCl3) δ: 0.18-0.20 (2H, m), 0.49-0.52 (2H, m), 0.95-1.00 (1H, m), 1.90-1.99 (2H, m), 2.77 (2H, t), 3.16 (2H, dd), 3.65-3.76 
               
               
                   
                 (3H, m), 4.07 (1H, d,), 5.15 (1H, t), 7.43-7.50 (6H, m). 
               
               
                 3-661A 
                 1H-NMR (CDCl3) δ: 1.92-2.00 (2H, m), 2.78 (2H, t), 3.65-4.15 (6H, m), 5.38 (1H, t), 7.41-7.46 (6H, m). 
               
               
                 3-663 
                 1H-NMR (CDCl3) δ: 1.91-1.99 (2H), 2.77 (2H, t), 3.67 (1H, d), 3.75 (2H, t), 3.91-3.93 (2H), 4.06 (1H, d), 5.09-5.20 (3H, m), 
               
               
                   
                 5.82-5.93 (1H, m), 7.43-7.50 (6H). 
               
               
                 3-664 
                 1H-NMR (CDCl3) δ: 1.95-1.97 (2H), 2.24 (1H, t), 2.77 (2H, t), 3.67 (1H, d), 3.75 (2H, t), 4.06-4.09 (3H), 5.21 (1H), 7.43-7.50 (6H). 
               
               
                 3-777 
                 1H-NMR (CDCl3) δ: 3.81 (d, 1H), 4.20 (d, 1H), 7.40-7.49 (m, 2H), 7.54 (s, 2H), 7.96 (s, 1H), 8.01-8.22 (m, 3H) 
               
               
                 3-193 
                 1H-NMR (CDCl3) δ: 1.13 (3H, t), 1.72-1.77 (1H, m), 2.55-2.62 (1H, m), 2.81-2.90 (2H, m), 3.19-3.24 (2H, m), 3.49 (1H, d), 3.90 
               
               
                   
                 (1H, d), 4.48 (1H, d), 4.64-4.66 (1H, m), 4.83 (1H, d), 4.97 (1H, d), 5.29-5.31 (1H, m), 7.36 (1H, d), 7.63-7.72 (2H, m), 
               
               
                   
                 7.82 (2H, s), 7.91 (1H, s) 
               
               
                 3-778 
                 1H-NMR (CDCl3) δ: 2.21 (3H, s), 3.79 (1H, d, J = 17.2 Hz), 4.16 (2H, d, J = 17.2 Hz), 4.69 (2H, s), 7.41-7.42 (1H, m), 
               
               
                   
                 7.52-7.55 (3H, m), 7.93-7.94 (1H, m), 8.03-8.06 (1H, m) 
               
               
                 3-779 
                 1H-NMR (CDCl3) δ: 3.76 (d, 1H), 4.15 (d, 1H), 6.78 (d, 1H), 7.41-7.50 (m, 2H), 7.53 (s, 2H), 7.78-7.94 (m, 3H) 
               
               
                 3-781 
                 1H-NMR (CDCl3) δ: 2.10 (3H, d), 3.67-3.84 (1H, m), 4.08-4.21 (1H, m), 4.56 (1H, d), 6.99-7.07 (2H, m), 7.29-7.54 (4H, m), 8.35 
               
               
                   
                 (1H, s). 
               
               
                 3-782 
                 1H-NMR (CDCl3) δ: 3.67 (1H, d), 4.05 (1H, d), 7.10-7.13 (1H, m), 7.28-7.31 (1H, m), 7.43-7.44 (1H, m), 7.50-7.51 (3H, m). 
               
               
                 3-784 
                 1H-NMR (CDCl3) δ: 3.22 (s, 6H), 3.75 (d, 1H), 3.90 (s, 2H), 4.14 (d, 1H), 7.43 (s, 1H), 7.52 (s, 2H), 7.56-7.63 (m, 2H), 7.83 
               
               
                   
                 (s, 1H), 7.87 (d, 1H) 
               
               
                 3-785 
                 1H-NMR (CDCl3) δ: 3.70-4.18 (m), 5.07 (m), 6.50 (m), 7.27-7.92 (m), 10.11 (s) 
               
               
                 3-786 
                 1H-NMR (CDCl3) δ: 1.25 (3H, t), 3.42-3.49 (2H, m), 3.74 (1H, d), 4.13 (1H, d), 4.93 (2H, s), 7.44-7.44 (1H, m), 7.51 (2H, s), 
               
               
                   
                 7.66 (1H, d), 7.76 (1H, s), 7.82-7.83 (2H, m), 9.71 (1H, br s) 
               
               
                 3-793 
                 1H-NMR (CDCl3) δ: 1.13 (t, 3H), 1.60-1.81 (m, 1H), 2.47-2.62 (m, 1H), 2.70-2.97 (m, 2H), 3.14-3.28 (m, 2H), 3.73 (d, 1H), 4.12 
               
               
                   
                 (d, 1H), 4.53-4.64 (m, 1H), 4.71-7.82 (m, 1H), 5.27 (q, 1H), 7.28-7.93 (m, 7H) 
               
               
                 3-828 
                 1H-NMR (CDCl3) δ: 1.64-1.84 (4H), 1.89-1.97 (2H, m), 2.31-2.38 (2H, m), 2.76 (2H, t), 3.65-3.73 (3H), 4.07 (1H, d), 4.35-4.38 
               
               
                   
                 (1H, m), 5.17 (1H, d), 7.40-7.52 (6H) 
               
               
                 3-829 
                 1H-NMR (CDCl3) δ: 1.71-1.92 (m, 3H), 1.98-2.14 (m, 1H), 2.72-2.84 (m, 2H), 2.92 (s, 6H), 3.68 (d, 1H), 4.06 (d, 1H), 4.56 (d, 1H), 
               
               
                   
                 5.03-5.15 (m, 1H), 7.33-7.56 (m, 6H) 
               
               
                 3-830 
                 1H-NMR (CDCl3) δ: 2.02-2.20 (m, 1H), 2.45-2.62 (m, 1H), 2.83-2.98 (m, 1H), 3.06-3.21 (m, 1H), 3.74 (d, 1H), 4.20 (d, 1H), 6.14-6.23 
               
               
                   
                 (m, 1H), 7.42-7.64 (m, 3H), 7.96 (s, 1H), 8.08 (s, 2H) 
               
               
                 3-831 
                 1H-NMR (CDCl3) δ: 1.58-1.81 (m, 3H), 2.48-2.61 (m, 1H), 2.75-3.06 (m, 2H), 3.75 (d, 1H), 4.20 (d, 1H), 4.38 (t, 1H), 7.34-7.61 
               
               
                   
                 (m, 3H), 7.96 (s, 1H), 8.09 (s, 2H) 
               
               
                 3-832 
                 1H-NMR (CDCl3) δ: 1.74-1.88 (m, 1H), 2.56-2.73 (m, 1H), 2.78-3.07 (m, 8H), 3.74 (d, 1H), 4.20 (d, 1H), 4.56 (d, 1H), 5.42 (q, 1H), 
               
               
                   
                 7.34-7.61 (m, 3H), 7.96 (s, 1H), 8.09 (s, 2H) 
               
               
                 3-833 
                 1H-NMR (CDCl3) δ: 1.89-2.06 (m, 1H), 2.66-2.82 (m, 1H), 2.87-3.13 (m, 2H), 3.76 (d, 1H), 4.21 (d, 1H), 5.73 (q, 1H), 6.44 (d, 1H), 
               
               
                   
                 7.26-7.76 (m, 7H), 7.96 (s, 1H), 8.09 (s, 2H) 
               
               
                 3-834 
                 1H-NMR (CDCl3) δ: 1.93-1.99 (1H, m), 2.66-2.76 (1H, m), 2.94-3.05 (2H, m), 3.76 (1H, dd), 4.20 (1H, dd), 5.67-5.70 (1H, m), 6.44-6.47 
               
               
                   
                 (1H, m), 7.28-7.39 (2H, m), 7.45-7.67 (4H, m), 7.76 (1H, s), 7.97 (1H, s), 8.09 (2H, s) 
               
               
                 3-835 
                 1H-NMR (CDCl3) δ: 1.72-2.05 (m, 3H), 2.09-2.40 (m, 4H), 2.54-2.70 (m, 1H), 2.79-3.12 (m, 3H), 3.75 (d, 1H), 4.20 (d, 1H), 5.44-5.63 
               
               
                   
                 (m, 2H), 7.21-7.63 (m, 3H), 7.96 (s, 1H), 8.09 (s, 2H) 
               
               
                 3-836 
                 1H-NMR (CDCl3) δ: 1.69-1.85 (m, 1H), 2.51-2.68 (m, 1H), 2.75-3.02 (m, 2H), 3.74 (d, 1H), 3.81-3.97 (m, 2H), 4.19 (d, 1H), 4.78-4.94 
               
               
                   
                 (m, 1H), 5.23-5.37 (m, 1H), 7.28-7.56 (m, 3H), 7.96 (s, 1H), 8.08 (s, 2H) 
               
               
                 3-837 
                 1H-NMR (CDCl3) δ: 1.71-1.88 (m, 1H), 2.53-2.68 (m, 1H), 2.75-3.03 (m, 2H), 3.74 (d, 1H), 4.19 (d, 1H), 4.48 (bs, 1H), 4.76-4.90 
               
               
                   
                 (m, 1H), 5.28 (q, 1H), 7.32-7.59 (m, 3H), 7.96 (s, 1H), 8.08 (s, 2H) 
               
               
                 3-838 
                 1H-NMR (CDCl3) δ: 0.50-0.63 (m, 2H), 0.67-0.79 (m, 2H), 1.74-1.91 (m, 1H), 2.38-2.51 (m, 1H), 2.59-2.74 (m, 1H), 2.78-3.08 (m, 2H), 
               
               
                   
                 3.76 (d, 1H), 4.21 (d, 1H), 4.91 (s, 1H), 5.20 (d, 1H), 5.42 (q, 1H), 7.33-7.65 (m, 3H), 7.96 (s, 1H), 8.09 (s, 2H) 
               
               
                 3-839 
                 1H-NMR (CDCl3) δ: 1.69-1.86 (m, 1H), 2.20-2.35 (m, 2H), 2.56-2.70 (m, 1H), 2.77-3.04 (m, 2H), 3.74 (d, 1H), 3.98 (t, 4H), 4.14-4.25 
               
               
                   
                 (m, 2H), 5.39 (q, 1H), 7.34-7.60 (m, 3H), 7.96 (s, 1H), 8.09 (s, 2H) 
               
               
                 3-840 
                 1H-NMR (CDCl3) δ: 1.50 (9H, s), 1.81-1.87 (1H, m), 2.60-2.63 (1H, m), 2.88-2.97 (2H, m), 3.51 (1H, d), 3.92 (1H, d), 4.49 (1H, d), 
               
               
                   
                 4.85-4.88 (1H, m), 4.99 (1H, d), 5.20-5.23 (1H, m), 7.40 (1H, d), 7.70-7.75 (2H, m), 7.84 (2H, s), 7.91 (1H, s) 
               
               
                 3-841 
                 1H-NMR (CDCl3) δ: 1.67-1.86 (m, 1H), 2.50-2.66 (m, 1H), 2.73-3.01 (m, 2H), 3.68 (d, 1H), 4.08 (d, 1H), 4.54 (bs, 2H), 4.89-5.00 
               
               
                   
                 (m, 1H), 5.18-5.34 (m, 1H), 7.29-7.56 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-842 
                 1H-NMR (CDCl3) δ: 1.93-2.10 (m, 1H), 2.64-3.11 (m, 3H), 3.69 (d, 1H), 4.08 (d, 1H), 4.87 (d, 1H), 5.12 (q, 1H), 6.28 (t, 1H), 
               
               
                   
                 7.45-7.74 (m, 5H) 
               
               
                 3-843 
                 1H-NMR (CDCl3) δ: 1.90-2.06 (m, 1H), 2.59-3.12 (m, 3H), 3.68 (d, 1H), 3.82-3.97 (m, 2H), 4.08 (d, 1H), 4.87 (d, 1H), 5.04 (q, 1H), 
               
               
                   
                 7.41-7.68 (m, 5H) 
               
               
                 3-844 
                 1H-NMR (CDCl3) δ: 1.72-1.99 (m, 5H), 2.57-2.73 (m, 1H), 2.77-3.04 (m, 2H), 3.26-3.45 (m, 4H), 3.69 (d, 1H), 4.08 (d, 1H), 4.38 
               
               
                   
                 (d, 1H), 5.45 (q, 1H), 7.35-7.58 (m, 3H), 7.65 (s, 2H) 
               
               
                 3-845 
                 1H-NMR (CDCl3) δ: 1.77-1.96 (m, 1H), 2.29 (s, 3H), 2.54-2.70 (m, 1H), 2.80-3.09 (m, 2H), 3.49 (s, 2H), 3.67 (d, 1H), 4.08 (d, 1H), 
               
               
                   
                 5.50 (q, 1H), 7.27-7.59 (m, 3H), 7.65 (s, 2H) 
               
               
                 3-846 
                 1H-NMR (CDCl3) δ: 1.80-1.98 (m, 1H), 2.57-2.73 (m, 1H), 2.83-3.12 (m, 2H), 3.45 (s, 2H), 3.69 (d, 1H), 4.08 (d, 1H), 5.49 (q, 1H), 
               
               
                   
                 6.35 (d, 1H), 7.28-7.61 (m, 3H), 7.65 (s, 2H) 
               
               
                 3-847 
                 1H-NMR (CDCl3) δ: 1.79-1.94 (m, 1H), 2.57-2.74 (m, 1H), 2.82-3.08 (m, 2H), 3.68 (d, 1H), 4.08 (d, 1H), 5.61 (q, 1H), 5.67-5.84 
               
               
                   
                 (m, 2H), 6.12 (dd 1H), 6.36 (dd, 1H), 7.30-7.67 (m, 5H) 
               
               
                 3-848 
                 1H-NMR (CDCl3) δ: 1.86-2.03 (m, 1H), 2.61-2.78 (m, 1H), 2.86-3.13 (m, 2H), 3.69 (d, 1H), 4.08 (d, 1H), 5.69 (q, 1H), 6.46-6.59 
               
               
                   
                 (m, 2H), 7.14-7.20 (m, 1H), 7.39-7.71 (m, 6H) 
               
               
                 3-849 
                 1H-NMR (CDCl3) δ: 1.62-1.80 (m, 1H), 2.40-2.58 (m, 1H), 2.62-2.92 (m, 2H), 3.69 (d, 1H), 3.99-4.18 (m, 3H), 5.09-5.41 (m, 3H), 
               
               
                   
                 7.15-7.46 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-850 
                 1H-NMR (CDCl3) δ: 1.76-1.93 (m, 1H), 2.28 (s, 6H), 2.55-2.70 (m, 1H), 2.80-3.09 (m, 5H), 3.68 (d, 1H), 4.08 (d, 1H), 5.54 (q, 1H), 
               
               
                   
                 7.27-7.60 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-851 
                 1H-NMR (CDCl3) δ: 0.13-0.22 (m, 2H), 0.43-0.54 (m, 2H), 0.86-1.03 (m, 1H), 1.69-1.84 (m, 1H), 2.52-2.67 (m, 1H), 2.73-2.99 (m, 2H), 
               
               
                   
                 3.06 (t, 2H), 3.68 (d, 1H), 4.07 (d, 1H), 4.59-4.76 (m, 2H), 5.32 (q, 1H), 7.31-7.54 (m, 3H), 7.65 (s, 2H) 
               
               
                 3-852 
                 1H-NMR (CDCl3) δ: 0.98 (t, 3H), 1.63-1.88 (m, 3H), 2.22 (t, 2H), 2.55-2.70 (m, 1H), 2.80-3.06 (m, 2H), 3.68 (d, 1H), 4.08 (d, 1H), 
               
               
                   
                 5.53 (q, 1H), 5.68 (d, 1H), 7.28-7.58 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-853 
                 1H-NMR (CDCl3) δ: 1.79-1.94 (m, 1H), 2.14 (s, 3H), 2.58-2.74 (m, 1H), 2.83-3.11 (m, 2H), 3.27 (s, 2H), 3.69 (d, 1H), 4.09 (d, 1H), 
               
               
                   
                 5.52 (q, 1H), 7.08 (d, 1H), 7.28-7.72 (m, 5H) 
               
               
                 3-854 
                 1H-NMR (CDCl3) δ: 1.81-1.98 (m, 1H), 2.57-2.72 (m, 1H), 2.83-3.07 (m, 2H), 3.11 (s, 3H), 3.68 (d, 1H), 4.07 (d, 1H), 5.51 (q, 1H), 
               
               
                   
                 6.57 (d, 1H), 7.32-7.60 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-855 
                 1H-NMR (CDCl3) δ: 1.63-1.94 (m, 2H), 2.09-2.36 (m, 2H), 2.56-2.72 (m, 1H), 2.81-3.10 (m, 2H), 3.68 (d, 1H), 4.07 (d, 1H), 5.55 
               
               
                   
                 (q, 1H), 5.93 (d, 1H), 7.28-7.69 (m, 5H) 
               
               
                 3-856 
                 1H-NMR (CDCl3) δ: 0.87-1.06 (m, 1H), 1.23-1.46 (m, 1H), 1.69-1.90 (m, 1H), 2.54-2.72 (m, 1H), 2.76-3.06 (m, 3H), 3.68 (d, 1H), 
               
               
                   
                 4.07 (d, 1H), 4.39-4.69 (m, 1H), 4.77 (s, 1H), 5.04 (d, 1H), 5.38 (q, 1H), 7.30-7.59 (m, 3H), 7.65 (s, 2H) 
               
               
                 3-857 
                 1H-NMR (CDCl3) δ: 0.29 (s, 9H), 2.33-2.50 (m, 1H), 2.77-2.92 (m, 1H), 2.98-3.31 (m, 2H), 3.71 (d, 1H), 4.09 (d, 1H), 6.30 (t, 1H), 
               
               
                   
                 7.20 (d, 1H), 7.27 (s, 1H), 7.40-7.57 (m, 4H), 7.71 (d, 1H) 
               
               
                 3-858 
                 1H-NMR (CDCl3) δ: 2.35-2.51 (m, 1H), 2.80-2.95 (m, 1H), 3.01-3.31 (m, 2H), 3.71 (d, 1H), 4.09 (d, 1H), 6.22-6.32 (m, 1H), 7.14-7.77 
               
               
                   
                 (m, 7H) 
               
               
                 3-859 
                 1H-NMR (CDCl3) δ: 1.64-1.82 (m, 1H), 2.48-2.65 (m, 1H), 2.70-2.96 (m, 2H), 3.68 (d, 1H), 4.06 (d, 1H), 5.12-5.25 (m, 1H), 5.29-5.44 
               
               
                   
                 (m, 1H), 6.60 (m, 1H), 6.97-7.58 (m, 11H) 
               
               
                 3-860 
                 1H-NMR (CDCl3) δ: 1.76-1.94 (m, 1H), 2.57-2.73 (m, 1H), 2.79-3.06 (m, 2H), 3.69 (d, 1H), 4.07 (d, 1H), 5.09-5.20 (m, 1H), 5.42 
               
               
                   
                 (q, 1H), 6.80 (s, 1H), 6.91-7.03 (m, 1H), 7.18-7.61 (m, 8H), 8.07-8.18 (m, 1H) 
               
               
                 3-861 
                 1H-NMR (CDCl3) δ: 1.77-1.93 (m, 1H), 2.59-2.74 (m, 1H), 2.80-3.06 (m, 2H), 3.69 (d, 1H), 4.07 (d, 1H), 4.89-5.00 (m, 1H), 5.36-5.48 
               
               
                   
                 (m, 1H), 6.52 (s, 1H), 7.13-7.64 (m, 9H), 7.95-8.03 (m, 1H) 
               
               
                 3-862 
                 1H-NMR (CDCl3) δ: 1.79-1.97 (m, 1H), 2.58-2.74 (m, 1H), 2.81-3.10 (m, 2H), 3.61-3.78 (m, 4H), 4.08 (d, 1H), 5.43 (q, 1H), 5.89 
               
               
                   
                 (d, 1H), 7.16 (s, 1H), 7.33-7.63 (m, 6H) 
               
               
                 3-863 
                 1H-NMR (CDCl3) δ: 1.21 (t, 3H), 1.76-1.92 (m, 1H), 2.57-2.71 (m, 1H), 2.79-3.05 (m, 2H), 3.67 (d, 1H), 3.85 (q, 2H), 4.05 (d, 1H), 
               
               
                   
                 5.40 (q, 1H), 5.87 (d, 1H), 7.15 (s, 1H), 7.30-7.62 (m, 6H) 
               
               
                 3-864 
                 1H-NMR (CDCl3) δ: 1.78-1.94 (m, 1H), 2.57-2.73 (m, 1H), 2.80-3.08 (m, 2H), 3.70 (d, 1H), 4.08 (d, 1H), 4.29 (d, 2H), 5.24-5.51 
               
               
                   
                 (m, 3H), 5.80-6.03 (m, 2H), 7.21 (s, 1H), 7.32-7.65 (m, 6H) 
               
               
                 3-865 
                 1H-NMR (CDCl3) δ: 1.75-1.93 (m, 1H), 2.55-2.72 (m, 1H), 2.79-3.06 (m, 2H), 3.15 (s, 3H), 3.56-3.77 (m, 4H), 4.07 (d, 1H), 5.38 
               
               
                   
                 (q, 1H), 5.96 (d, 1H), 7.31-7.62 (m, 6H) 
               
               
                 3-866 
                 1H-NMR (CDCl3) δ: 1.45 (d, 3H), 1.71-1.90 (m, 1H), 2.28 (s, 3H), 2.54-2.70 (m, 1H), 2.80-3.08 (m, 2H), 3.45 (q, 1H), 3.68 (d, 1H), 
               
               
                   
                 4.07 (d, 1H), 5.40-5.55 (m, 1H), 6.40-6.54 (m, 1H), 7.21-7.60 (m, 6H) 
               
               
                 3-867 
                 1H-NMR (CDCl3) δ: 1.65-1.97 (m, 5H), 2.19-2.43 (m, 1H), 2.54-2.71 (m, 1H), 2.80-3.14 (m, 4H), 3.69 (d, 1H), 4.07 (d, 1H), 5.51 
               
               
                   
                 (q, 1H), 7.20-7.63 (m, 6H) 
               
               
                 3-868 
                 1H-NMR (CDCl3) δ: 0.17-0.27 (m, 2H), 0.56-0.66 (m, 2H), 0.91-1.06 (m, 1H), 1.74-1.90 (m, 1H), 2.18-2.30 (m, 2H), 2.60-2.73 (m, 1H), 
               
               
                   
                 2.82-3.08 (m, 2H), 3.69 (d, 1H), 4.08 (d, 1H), 5.56 (q, 1H), 6.05 (d, 1H), 7.29-7.61 (m, 6H) 
               
               
                 3-869 
                 1H-NMR (CDCl3) δ: 0.93 (t, 3H), 1.30-1.45 (m, 2H), 1.58-1.87 (m, 3H), 2.23 (t, 2H), 2.55-2.70 (m, 1H), 2.80-3.06 (m, 2H), 3.69 
               
               
                   
                 (d, 1H), 4.08 (d, 1H), 5.52 (q, 1H), 5.68 (d, 1H), 7.28-7.61 (m, 6H) 
               
               
                 3-870 
                 1H-NMR (CDCl3) δ: 0.89 (t, 3H), 1.41-1.55 (m, 2H), 1.60-1.77 (m, 1H), 2.42-2.57 (m, 1H), 2.65-2.92 (m, 2H), 3.05-3.18 (m, 2H), 3.69 
               
               
                   
                 (d, 1H), 4.06 (d, 1H), 4.83-5.29 (m, 3H), 7.21-7.47 (m, 4H), 7.51 (s, 2H) 
               
               
                 3-871 
                 1H-NMR (CDCl3) δ: 2.28-2.54 (m, 2H), 2.65-2.78 (m, 4H), 2.87-3.05 (m, 1H), 3.23-3.40 (m, 1H), 3.67 (d, 1H), 4.07 (d, 1H), 5.68-5.78 
               
               
                   
                 (m, 1H), 7.04-7.13 (m, 1H), 7.37-7.60 (m, 5H) 
               
               
                 3-872 
                 1H-NMR (CDCl3) δ: 1.79-1.94 (m, 1H), 2.14 (s, 3H), 2.59-2.74 (m, 1H), 2.84-3.10 (m, 2H), 3.27 (s, 2H), 3.70 (d, 1H), 4.08 (d, 1H), 
               
               
                   
                 5.53 (q, 1H), 7.02-7.14 (m, 1H), 7.28-7.64 (m, 6H) 
               
               
                 3-873 
                 1H-NMR (CDCl3) δ: 1.84-2.01 (m, 1H), 2.56-2.77 (m, 4H), 2.82-3.10 (m, 2H), 3.29 (d, 1H), 3.62-3.81 (m, 2H), 4.07 (d, 1H), 5.53 
               
               
                   
                 (q, 1H), 7.12-7.65 (m, 7H) 
               
               
                 3-874 
                 1H-NMR (CDCl3) δ: 1.81-1.97 (m, 1H), 2.55-2.70 (m, 1H), 2.81-3.12 (m, 5H), 3.69 (d, 1H), 3.90 (s, 2H), 4.07 (d, 1H), 5.49 (q, 1H), 
               
               
                   
                 6.67 (d, 1H), 7.29-7.61 (m, 6H) 
               
               
                 3-875 
                 1H-NMR (CDCl3) δ: 1.22-1.32 (m, 3H), 1.77-1.95 (m, 1H), 2.50-2.72 (m, 3H), 2.82-3.11 (m, 2H), 3.22-3.38 (m, 2H), 3.70 (d, 1H), 4.08 
               
               
                   
                 (d, 1H), 5.51 (q, 1H), 7.05-7.16 (m, 1H), 7.26-7.64 (m, 6H) 
               
               
                 3-876 
                 1H-NMR (CDCl3) δ: 1.71-1.90 (m, 1H), 2.55-2.71 (m, 1H), 2.80-3.14 (m, 4H), 3.69 (d, 1H), 4.08 (d, 1H), 5.18-5.31 (m, 2H), 5.52 
               
               
                   
                 (q, 1H), 5.77 (d, 1H), 5.86-6.04 (m, 1H), 7.24-7.63 (m, 6H) 
               
               
                 3-877 
                 1H-NMR (CDCl3) δ: 1.68-1.84 (m, 1H), 2.18-2.25 (m, 1H), 2.51-2.66 (m, 1H), 2.72-2.99 (m, 2H), 3.69 (d, 1H), 3.94-4.12 (m, 3H), 
               
               
                   
                 4.69-4.87 (m, 2H), 5.31 (q, 1H), 7.28-7.57 (m, 6H) 
               
               
                 3-878 
                 1H-NMR (CDCl3) δ: 0.98 (t, 3H), 1.65-1.89 (m, 3H), 2.21 (t, 2H), 2.55-2.70 (m, 1H), 2.81-3.06 (m, 2H), 3.69 (d, 1H), 4.08 (d, 1H), 
               
               
                   
                 5.52 (q, 1H), 5.70 (d, 1H), 7.26-7.62 (m, 6H) 
               
               
                 3-879 
                 1H-NMR (CDCl3) δ: 2.08-2.23 (m, 1H), 2.42-2.58 (m, 1H), 2.83-3.17 (m, 2H), 3.69 (d, 1H), 4.08 (d, 1H), 4.81-4.93 (m, 1H), 7.37-7.66 
               
               
                   
                 (m, 6H) 
               
               
                 3-880 
                 1H-NMR (CDCl3) δ: 1.76-1.95 (m, 1H), 2.57-2.78 (m, 1H), 2.82-3.24 (m, 4H), 3.69 (d, 1H), 4.10 (d, 1H), 5.53 (q, 1H), 5.98 (d, 1H), 
               
               
                   
                 7.26-7.62 (m, 3H), 7.68 (s, 2H) 
               
               
                 3-881 
                 1H-NMR (CDCl3) δ: 1.75-1.94 (m, 1H), 2.56-2.72 (m, 1H), 2.81-3.24 (m, 4H), 3.71 (d, 1H), 4.12 (d, 1H), 5.52 (q, 1H), 5.96-6.14 
               
               
                   
                 (m, 1H), 7.23-7.90 (m, 6H) 
               
               
                 3-882 
                 1H-NMR (CDCl3) δ: 1.75-1.92 (m, 1H), 2.54-2.73 (m, 1H), 2.79-3.21 (m, 4H), 3.71 (d, 1H), 4.07 (d, 1H), 5.51 (q, 1H), 6.01-6.16 
               
               
                   
                 (m, 1H), 7.21-7.65 (m, 7H) 
               
               
                 3-883 
                 1H-NMR (CDCl3) δ: 1.77-1.93 (m, 1H), 2.56-2.73 (m, 1H), 2.82-3.21 (m, 4H), 3.68 (d, 1H), 4.06 (d, 1H), 5.53 (q, 1H), 5.96 (d, 1H), 
               
               
                   
                 6.80-6.94 (m, 1H), 7.08-7.63 (m, 5H) 
               
               
                 3-884 
                 1H-NMR (CDCl3) δ: 1.75-1.92 (m, 1H), 2.55-2.72 (m, 1H), 2.81-3.23 (m, 4H), 3.73 (d, 1H), 4.12 (d, 1H), 5.52 (q, 1H), 5.94-6.13 
               
               
                   
                 (m, 1H), 7.20-7.85 (m, 7H) 
               
               
                 3-885 
                 1H-NMR (CDCl3) δ: 1.77-1.94 (m, 1H), 2.55-2.71 (m, 1H), 2.84-3.21 (m, 4H), 3.77 (d, 1H), 4.17 (d, 1H), 5.52 (q, 1H), 6.01-6.18 
               
               
                   
                 (m, 1H), 7.24-7.76 (m, 4H), 7.92-8.07 (m, 1H), 8.26-8.56 (m, 2H) 
               
               
                 3-886 
                 1H-NMR (CDCl3) δ: 1.76-1.93 (m, 1H), 2.53-2.69 (m, 1H), 2.81-3.23 (m, 4H), 3.71 (d, 1H), 4.13 (d, 1H), 5.49 (q, 1H), 6.24-6.37 
               
               
                   
                 (m, 1H), 7.24-7.97 (m, 7H) 
               
               
                 3-887 
                 1H-NMR (CDCl3) δ: 1.75-1.93 (m, 1H), 2.53-2.73 (m, 1H), 2.81-3.21 (m, 4H), 3.74 (d, 1H), 4.13 (d, 1H), 5.52 (q, 1H), 5.89-6.09 
               
               
                   
                 (m, 1H), 7.21-7.91 (m, 7H) 
               
               
                 3-888 
                 1H-NMR (CDCl3) δ: 1.77-1.94 (m, 1H), 2.60-2.74 (m, 1H), 2.83-3.21 (m, 4H), 3.71 (d, 1H), 4.11 (d, 1H), 5.55 (q, 1H), 5.82-5.95 
               
               
                   
                 (m, 1H), 7.27-7.82 (m, 6H) 
               
               
                 3-889 
                 1H-NMR (CDCl3) δ: 1.75-1.93 (m, 1H), 2.52 (s, 3H), 2.57-2.73 (m, 1H), 2.81-3.21 (m, 4H), 3.73 (d, 1H), 4.06 (d, 1H), 5.53 (q, 1H), 
               
               
                   
                 5.89-6.07 (m, 1H), 7.21-7.64 (m, 7H) 
               
               
                 3-890 
                 1H-NMR (CDCl3) δ: 1.74-1.92 (m, 1H), 2.55-2.70 (m, 1H), 2.79-3.21 (m, 4H), 3.69 (d, 1H), 4.07 (d, 1H), 5.50 (q, 1H), 6.02-6.17 
               
               
                   
                 (m, 1H), 7.23-7.77 (m, 6H) 
               
               
                 3-891 
                 1H-NMR (CDCl3) δ: 1.76-1.92 (m, 1H), 2.55-2.72 (m, 1H), 2.81-3.21 (m, 4H), 3.66 (d, 1H), 4.06 (d, 1H), 5.52 (q, 1H), 5.96-6.11 
               
               
                   
                 (m, 1H), 7.20-7.61 (m, 5H) 
               
               
                 3-892 
                 1H-NMR (CDCl3) δ: 1.77-1.93 (m, 1H), 2.54-2.75 (m, 1H), 2.83-3.22 (m, 4H), 3.77 (d, 1H), 4.23 (d, 1H), 5.55 (q, 1H), 5.81-5.95 
               
               
                   
                 (m, 1H), 7.29-8.72 (m, 6H) 
               
               
                 3-893 
                 1H-NMR (CDCl3) δ: 1.75-1.93 (m, 1H), 2.56-2.71 (m, 1H), 2.81-3.21 (m, 4H), 3.71 (d, 1H), 4.09 (d, 1H), 5.51 (q, 1H), 5.96-6.11 
               
               
                   
                 (m, 1H), 7.21-7.62 (m, 7H) 
               
               
                 3-894 
                 1H-NMR (CDCl3) δ: 1.75-1.92 (m, 1H), 2.53-2.68 (m, 1H), 2.78-3.20 (m, 4H), 3.73 (d, 1H), 3.84 (s, 3H), 4.04 (d, 1H), 5.48 (q, 1H), 
               
               
                   
                 6.11-6.24 (m, 1H), 6.88-7.60 (m, 6H) 
               
               
                 3-895 
                 1H-NMR (CDCl3) δ: 1.20 (t, 3H), 1.73-1.90 (m, 1H), 2.27 (q, 2H), 2.54-2.70 (m, 1H), 2.78-3.06 (m, 2H), 3.74 (d, 1H), 4.16 (d, 1H), 
               
               
                   
                 5.52 (q, 1H), 5.63-5.77 (m, 1H), 7.28-7.59 (m, 3H), 7.82 (d, 2H), 8.30 (d, 2H) 
               
               
                 3-896 
                 1H-NMR (CDCl3) δ: 1.20 (t, 3H), 1.73-1.89 (m, 1H), 2.27 (q, 2H), 2.53 (s, 3H), 2.56-2.70 (m, 1H), 2.81-3.08 (m, 2H), 3.75 (d, 1H), 
               
               
                   
                 4.14 (d, 1H), 5.52 (q, 1H), 5.63-5.75 (m, 1H), 7.29-7.70 (m, 3H), 7.81 (s, 1H), 8.10 (s, 1H), 8.25 (s, 1H) 
               
               
                 3-897 
                 1H-NMR (CDCl3) δ: 1.21 (t, 3H), 1.72-1.89 (m, 1H), 2.27 (q, 2H), 2.55-2.72 (m, 1H), 2.81-3.08 (m, 2H), 3.69 (d, 1H), 4.11 (d, 1H), 
               
               
                   
                 5.45-5.70 (m, 2H), 7.30-7.60 (m, 3H), 7.69 (s, 2H) 
               
               
                 3-898 
                 1H-NMR (CDCl3) δ: 1.20 (t, 3H), 1.73-1.90 (m, 1H), 2.27 (q, 2H), 2.54-2.70 (m, 1H), 2.79-3.07 (m, 2H), 3.71 (d, 1H), 4.13 (d, 1H), 
               
               
                   
                 5.52 (q, 1H), 5.62-5.76 (m, 1H), 7.23-7.62 (m, 4H), 7.76-7.91 (m, 2H) 
               
               
                 3-899 
                 1H-NMR (CDCl3) δ: 1.20 (t, 3H), 1.69-1.89 (m, 1H), 2.27 (q, 2H), 2.54-2.69 (m, 1H), 2.80-3.05 (m, 2H), 3.72 (d, 1H), 4.12 (d, 1H), 
               
               
                   
                 5.51 (q, 1H), 5.69-5.83 (m, 1H), 7.28-7.82 (m, 6H) 
               
               
                 3-900 
                 1H-NMR (CDCl3) δ: 1.20 (t, 3H), 1.68-1.90 (m, 1H), 2.27 (q, 2H), 2.53-2.68 (m, 1H), 2.78-3.06 (m, 2H), 3.69 (d, 1H), 4.08 (d, 1H), 
               
               
                   
                 5.50 (q, 1H), 5.73-5.88 (m, 1H), 7.26-7.78 (m, 6H) 
               
               
                 3-901 
                 1H-NMR (CDCl3) δ: 1.20 (t, 3H), 1.73-1.89 (m, 1H), 2.27 (q, 2H), 2.54-2.70 (m, 1H), 2.79-3.07 (m, 2H), 3.71 (d, 1H), 4.13 (d, 1H), 
               
               
                   
                 5.46-5.74 (m, 2H), 7.22-7.96 (m, 7H) 
               
               
                 3-902 
                 1H-NMR (CDCl3) δ: 1.20 (t, 3H), 1.73-1.89 (m, 1H), 2.27 (q, 2H), 2.53-2.70 (m, 4H), 2.80-3.06 (m, 2H), 3.74 (d, 1H), 4.12 (d, 1H), 
               
               
                   
                 5.52 (q, 1H), 5.69 (d, 1H), 7.28-7.82 (m, 5H), 8.20 (s, 1H) 
               
               
                 3-903 
                 1H-NMR (CDCl3) δ: 1.20 (t, 3H), 1.73-1.88 (m, 1H), 2.27 (q, 2H), 2.55-2.70 (m, 1H), 2.80-3.07 (m, 2H), 3.77 (d, 1H), 4.17 (d, 1H), 
               
               
                   
                 5.52 (q, 1H), 5.70 (d, 1H), 7.28-7.74 (m, 4H), 7.95-8.51 (m, 3H) 
               
               
                 3-904 
                 1H-NMR (CDCl3) δ: 1.75-1.91 (m, 4H), 2.54-2.71 (m, 1H), 2.80-3.19 (m, 4H), 3.45 (s, 2H),, 5.51 (q, 1H), 6.03 (d, 1H), 7.17-7.79 
               
               
                   
                 (m, 6H) 
               
               
                 3-910 
                 1H-NMR (CDCl3) δ: 1.58 (9H, s), 3.53 (1H, d), 3.92 (1H, d), 4.46 (1H, d), 4.91 (1H, d), 6.81 (1H, s), 7.42-7.44 (3H, m), 7.79-7.82 
               
               
                   
                 (2H, m), 8.02-8.08 (3H, m). 
               
               
                 3-912 
                 1H-NMR (CDCl3) δ: 2.26 (3H, s), 3.55 (1H, d), 3.92 (1H, d), 4.47 (1H, d), 4.92 (1H, d), 7.38 (1H, s), 7.45 (2H, s), 7.52 (1H, d), 
               
               
                   
                 7.85 (2H, d), 8.05 (1H, d), 8.12 (1H, s), 8.23 (1H, s). 
               
               
                 3-913 
                 1H-NMR (CDCl3) δ: 1.26-1.33 (3H, m), 2.44-2.52 (2H, m), 3.55 (1H, d), 3.92 (1H, d), 4.47 (1H, d), 4.92 (1H, d), 7.34 (1H, s), 7.45 
               
               
                   
                 (2H, s), 7.53 (1H, d), 7.85 (2H, t), 8.04 (1H, d), 8.12 (1H, s), 8.26 (1H, s). 
               
               
                 3-914 
                 1H-NMR (CDCl3) δ: 0.87-0.90 (2H, m), 1.13-1.15 (2H, m), 1.56-1.61 (1H, m), 3.53 (1H, d), 3.91 (1H, d), 4.46 (1H, d), 4.91 (1H, d), 
               
               
                   
                 7.43-7.56 (3H, m), 7.78-7.83 (3H, m), 8.02 (1H, d), 8.10 (1H, s), 8.23 (1H, s). 
               
               
                 3-916 
                 1H-NMR (CDCl3) δ: 1.16-1.19 (3H, m), 3.27-3.38 (2H, m), 3.51 (1H, d), 3.90 (1H, d), 4.45 (1H, d), 4.90 (1H, d), 5.05-5.07 (1H, m), 
               
               
                   
                 6.95 (1H, s), 7.41-7.42 (3H, m), 7.73-7.78 (2H, m), 7.90 (1H, s), 7.98-8.00 (1H, m), 8.07 (1H, s). 
               
               
                 3-917 
                 1H-NMR (CDCl3) δ: 1.76-1.95 (m, 3H), 2.01-2.17 (m, 1H), 2.69-2.94 (m, 2H), 3.44 (s, 2H), 3.67 (d, 1H), 4.06 (d, 1H), 5.12-5.27 
               
               
                   
                 (m, 1H), 6.20-6.34 (m, 1H), 7.23-7.52 (m, 3H), 7.64 (s, 2H) 
               
               
                 3-918 
                 1H-NMR (CDCl3) δ: 1.76-1.95 (m, 3H), 2.00-2.17 (m, 1H), 2.71-2.95 (m, 2H), 3.44 (s, 2H), 3.74 (d, 1H), 4.19 (d, 1H), 5.14-5.28 
               
               
                   
                 (m, 1H), 6.24-6.38 (m, 1H), 7.25-7.57 (m, 3H), 7.97 (s, 1H), 8.09 (s, 2H) 
               
               
                 3-919 
                 1H-NMR (CDCl3) δ: 1.73-1.97 (m, 3H), 2.01-2.14 (m, 1H), 2.28 (s, 3H), 2.69-2.95 (m, 2H), 3.49 (s, 2H), 3.72 (d, 1H), 4.18 (d, 1H), 
               
               
                   
                 5.16-5.30 (m, 1H), 7.15-7.53 (m, 4H), 7.96 (s, 1H), 8.08 (s, 2H) 
               
               
                 3-920 
                 1H-NMR (CDCl3) δ: 1.57 (9H, s), 3.55 (1H, d), 3.93 (1H, d), 4.48 (1H, d), 4.93 (1H, d), 6.94 (1H, s), 7.48-7.51 (3H, m), 7.68 
               
               
                   
                 (1H, d), 7.91-7.98 (2H, m), 8.09-8.13 (2H, m). 
               
               
                 3-921 
                 1H-NMR (CDCl3) δ: 3.53 (1H, d, J = 17.6 Hz), 3.91 (1H, d, J = 17.6 Hz), 4.00 (2H, br s), 4.45 (1H, d), 4.89 (1H, d), 
               
               
                   
                 6.96-7.00 (2H, m), 7.45 (2H, s), 7.62 (1H, d), 7.72 (1H, d), 7.95 (1H, d), 8.03 (1H, s). 
               
               
                 3-922 
                 1H-NMR (CDCl3) δ: 1.49 (9H, s), 1.79-1.84 (4H, m), 2.80-2.82 (2H, m), 3.42 (1H, d), 3.78 (1H, d), 4.41 (1H, d), 4.84-4.87 (3H, m), 
               
               
                   
                 7.41-7.45 (3H, m), 7.57-7.64 (2H, m). 
               
               
                 3-923 
                 1H-NMR (CDCl3) δ: 1.75-1.93 (m, 1H), 2.53-2.73 (m, 1H), 2.81-3.21 (m, 4H), 3.74 (d, 1H), 4.13 (d, 1H), 5.52 (q, 1H), 5.89-6.09 
               
               
                   
                 (m, 1H), 7.21-7.91 (m, 7H) 
               
               
                 3-924 
                 1H-NMR (CDCl3) δ: 2.07 (s, 3H), 2.08-2.20 (m, 1H), 2.45-2.59 (m, 1H), 2.82-2.97 (m, 1H), 3.04-3.20 (m, 1H), 3.74 (d, 1H), 4.14 
               
               
                   
                 (d, 1H), 6.18 (dd, 1H), 7.41-7.91 (m, 7H) 
               
               
                 3-925 
                 1H-NMR (CDCl3) δ: 1.56 (bs, 2H), 1.63-1.80 (m, 1H), 2.45-2.60 (m, 1H), 2.74-3.05 (m, 2H), 3.74 (d, 1H), 4.14 (d, 1H), 4.37 (t, 1H), 
               
               
                   
                 7.34-7.94 (m, 7H) 
               
               
                 3-926 
                 1H-NMR (CDCl3) δ: 1.72-1.89 (m, 1H), 2.04 (s, 3H), 2.53-2.68 (m, 1H), 2.77-3.06 (m, 2H), 3.74 (d, 1H), 4.13 (d, 1H), 5.49 (q, 1H), 
               
               
                   
                 5.70-5.86 (m, 1H), 7.27-7.94 (m, 7H) 
               
               
                 3-927 
                 1H-NMR (CDCl3) δ: 1.20 (t, 3H), 1.73-1.88 (m, 1H), 2.26 (q, 2H), 2.54-2.69 (m, 1H), 2.78-3.07 (m, 2H), 3.74 (d, 1H), 4.13 (d, 1H), 
               
               
                   
                 5.52 (q, 1H), 5.62-5.76 (m, 1H), 7.27-7.93 (m, 7H) 
               
               
                 3-928 
                 1H-NMR (CDCl3) δ: 0.69-0.82 (m, 2H), 0.96-1.08 (m, 2H), 1.31-1.43 (m, 1H), 1.75-1.91 (m, 1H), 2.52-2.68 (m, 1H), 2.77-3.06 (m, 2H), 
               
               
                   
                 3.74 (d, 1H), 4.14 (d, 1H), 5.51 (q, 1H), 5.84-5.98 (m, 1H), 7.28-7.92 (m, 7H) 
               
               
                 3-929 
                 1H-NMR (CDCl3) δ: 0.16-0.29 (m, 2H), 0.54-0.66 (m, 2H), 0.89-1.06 (m, 1H), 1.74-1.90 (m, 1H), 2.22 (d, 2H), 2.58-2.73 (m, 1H), 
               
               
                   
                 2.81-3.09 (m, 2H), 3.74 (d, 1H), 4.14 (d, 1H), 5.55 (q, 1H), 6.01-6.13 (m, 1H), 7.29-7.92 (m, 7H) 
               
               
                 3-930 
                 1H-NMR (CDCl3) δ: 1.72-1.90 (m, 1H), 2.56-2.70 (m, 1H), 2.80-3.11 (m, 4H), 3.74 (d, 1H), 4.13 (d, 1H), 5.18-5.28 (m, 2H), 5.50 
               
               
                   
                 (q, 1H), 5.78-6.05 (m, 2H), 7.27-7.91 (m, 7H) 
               
               
                 3-932 
                 1H-NMR (CDCl3) δ: 1.78-1.93 (m, 1H), 2.13 (s, 3H), 2.58-2.72 (m, 1H), 2.83-3.11 (m, 2H), 3.27 (s, 2H), 3.75 (d, 1H), 4.14 (d, 1H), 
               
               
                   
                 5.53 (q, 1H), 7.01-7.12 (m, 1H), 7.29-7.91 (m, 7H) 
               
               
                 3-933 
                 1H-NMR (CDCl3) δ: 1.79-1.96 (m, 1H), 2.53-2.69 (m, 1H), 2.80-3.15 (m, 5H), 3.73 (d, 1H), 3.90 (s, 2H), 4.12 (d, 1H), 5.47 (q, 1H), 
               
               
                   
                 6.70-6.80 (m, 1H), 7.30-7.91 (m, 7H) 
               
               
                 3-934 
                 1H-NMR (CDCl3) δ: 0.52-0.62 (m, 2H), 0.67-0.78 (m, 2H), 1.73-1.90 (m, 1H), 2.37-2.49 (m, 1H), 2.59-2.74 (m, 1H), 2.80-3.06 (m, 2H), 
               
               
                   
                 3.74 (d, 1H), 4.14 (d, 1H), 4.83 (s, 1H), 5.12-5.23 (m, 1H), 5.42 (q, 1H), 7.33-7.92 (m, 7H) 
               
               
                 4-1 
                 1H-NMR ([D6]-DMSO) 4.30-4.43 (2H, AB spectrum); 6.34 (br. s, 2H); 7.61 (d, 2H); 7.66 (dd, 1H); 7.74 (m, 1H); 7.75 (br. s, 1H); 7.91 
               
               
                   
                 (dd, 1H) 
               
               
                 4-3 
                 1H-NMR (CD3CN) 1.21 (t, 3H); 2.52 (q, 2H); 4.01 (d, 1H); 4.27 (d, 1H); 7.56 (m, 1H); 7.60 (m, 2H); 7.72 (dd, 1H); 7.79 (m, 1H); 8.11 
               
               
                   
                 (dd, 1H); 8.90 (br. s, 1H) 
               
               
                 4-6 
                 1H-NMR (CD3CN) 1.24 (d, 6H); 2.76 (m, 1H); 4.04 (d, 1H); 4.27 (d, 1H); 7.56 (m, 1H); 7.60 (m, 2H); 7.72 (dd, 1H); 7.80 (m, 1H); 8.09 
               
               
                   
                 (dd, 1H); 8.88 (br. s, 1H) 
               
               
                 4-11 
                 1H-NMR d ([D 6 ]-DMSO) 4.34-4.49 (2H, AB spectrum); 7.62 (m, 2H); 7.75 (m, 1H); 7.83 (m, 1H); 8.05-8.07 (m, 2H); 12.5 
               
               
                   
                 (br. s, 1H) 
               
               
                 4-17 
                 1H-NMR d ([D 6 ]-DMSO) 3.78 (s, 3H); 4.32-4.64 (2H, AB spectrum); 7.62 (br. s, 2H); 7.74-7.77 (m, 2H); 7.96 (br. s, 1H); 8.13 
               
               
                   
                 (d, 1H); 10.72 (s, 1H) 
               
               
                 4-19 
                 1H-NMR d (CD 3 CN) 1.18 (d, 12 H); 3.06 (m, 2H); 4.03 (d, 1H); 4.29 (d, 1H); 7.57 (m, 1H); 7.61 (m, 2H); 7.64 (dd, 1H); 7.82 
               
               
                   
                 (dd, 1H); 7.96 (m, 1H) 
               
               
                 4-41 
                 1H-NMR ([D6]-DMSO) 3.96-4.27 (2H, AB spectrum); 5.04 (br. s, 2H); 7.47 (dd, 1H); 7.55 (m, 1H); 7.60 (br. s, 2H); 7.89 (dd, 1H); 
               
               
                   
                 8.03 (m, 1H) 
               
               
                 4-43 
                 1H-NMR (CD3CN) 1.26 (d, 6H); 2.78 (m, 1H); 3.98 (d, 1H); 4.24 (d, 1H); 7.55 (m, 1H); 7.60-7.63 (m, 3H); 7.96 (dd, 1H); 8.37 (m, 1H); 
               
               
                   
                 8.88 (br. s, 1H) 
               
               
                 4-44 
                 1H-NMR (CD3CN) 4.03 (d, 1H); 4.27 (d 1H); 7.58 (m, 1H); 7.63 (br. s, 2H); 7.30 (dd, 1H); 8.07 (dd, 1H); 8.27 (m, 1H) 
               
               
                 4-47 
                 1H-NMR ([D6]-DMSO) 1.18 (d, 6H); 3.9 (m, 1H); 4.28-4.31 (2H, AB spectrum); 6.98 (m, 1H); 7.63 (br. s, 2H); 7.70-7.73 (m, 3H); 
               
               
                   
                 7.98 (dd, 1H); 8.62 (m, 1H) 
               
               
                 4-48 
                 1H-NMR (CD3CN) 3.83 (s, 3H); 4.01 (d, 1H); 4.27 (d, 1H); 7.58 (m, 1H); 7.62-7.65 (m, 3H); 7.98 (dd, 1H); 8.38 (m, 1H); 8.6 (br. s, 1H) 
               
               
                 4-49 
                 1H-NMR (CD3CN) 3.95 (d, 1H); 4.22 (d, 1H); 7.26-7.33 (m, 3H); 7.42-7.49 (m, 2H); 7.54 (m, 1H); 7.60 (br. s, 2H); 7.65 (d, 1H); 8.00 
               
               
                   
                 (dd, 1H); 8.38 (m, 1H); 8.88 (br. s, 1H) 
               
               
                 4-50 
                 1H-NMR ([D6]-DMSO) 3.78 (s, 3H); 4.26-4.43 (2H, AB spectrum); 5.34 (br. s, 2H), 7.32 (dd, 1H); 7.62 (br. s, 2H); 7.65 (s, 1H); 
               
               
                   
                 7.73-7.75 (m, 2H) 
               
               
                 4-54 
                 1H-NMR (CD3CN) 3.78 (s, 3H); 3.97 (d, 1H); 4.23 (d, 1H); 7.29 (dd, 1H); 7.54 (m, 1H); 7.60 (br. s, 2H); 7.72 (dd, 1H); 7.89 (br. s, 1H) 
               
               
                 4-56 
                 1H-NMR (CD3CN) 1.25 (d, 6H); 2.71 (m, 1H); 3.94 (s, 3H); 3.97 (d, 1H); 4.23 (d, 1H); 7.46 (d, 1H); 7.54 (m, 1H); 7.62 (br. s, 2H); 
               
               
                   
                 7.79 (dd, 1H); 8.12 (br. s, 1H); 8.4 (br. s, 1H) 
               
               
                 4-57 
                 1H-NMR (CD3CN) 3.98 (d, 2H); 4.01 (s, 3H); 4.24 (d, 2H); 7.54-7.56 (m, 2H); 7.61 (br. s, 2H); 7.87 (dd, 1H); 8.04 (br. s, 1H); 
               
               
                   
                 9.51 (br. s, 1H) 
               
               
                 4-60 
                 1H-NMR ([D7]-DMF) 1.23 (d, 6H); 3.98 (m, 1H); 4.01 (s, 3H); 4.36-4.49 (2H, AB spectrum); 7.62 (br. d, 1H); 7.65 (br. d, 1H); 7.74 
               
               
                   
                 (br. s, 2H); 7.79 (m, 1H); 7.89 (dd, 1H); 8.57 (br. s, 1H); 9.48 (br. s, 1H) 
               
               
                 4-61 
                 1H-NMR ([D7]-DMF) 3.78 (s, 3H); 4.03 (s, 3H); 4.41-4.54 (2H, AB spectrum); 7.71 (br. d, 1H); 7.76 (br. s, 2H); 7.79 (m, 1H); 7.89 
               
               
                   
                 (dd, 1H); 8.29 (br. s, 1H); 10.0 (br. s, 1H) 
               
               
                 6-70 
                 1H-NMR (CDCl3) δ: 1.99-2.25 (4H, m), 2.50-2.66 (1H, m), 2.86-3.05 (1H, m), 3.09-3.28 (1H, m), 6.22 (1H, dd, J = 7.2, 4.5 Hz), 
               
               
                   
                 7.56 (1H, d), 7.75 (1H, d), 7.79 (1H, s), 10.02 (1H, s) 
               
               
                 6-175 
                 1H-NMR (CDCl3) δ: 1.76-2.20 (7H, m), 2.73-3.04 (2H, m), 6.03 (1H, t), 7.65 (1H, s), 7.68 (1H, d), 7.67 (1H, s), 9.98 (1H, s) 
               
               
                 7-446 
                 1H-NMR (CDCl3) δ: 0.17 (9H, s), 1.48 (9H, s), 1.75-1.82 (3H, m), 2.02-2.05 (1H, m), 2.78-2.80 (2H, m), 3.52 (2H, d), 4.74-4.81 
               
               
                   
                 (2H, m), 7.35-7.41 (2H, m), 7.47 (1H, s), 7.59 (1H, br s). 
               
               
                 7-470 
                 1H-NMR (CDCl3) δ: 0.20 (9H, s), 1.56 (9H, s), 3.56 (2H, d), 6.88 (1H, s), 7.40 (1H, t), 7.55 (1H, d), 7.73-7.79 (3H, m), 7.96 
               
               
                   
                 (1H, s), 8.07 (1H, br s). 
               
               
                 7-480 
                 1H-NMR (CDCl3) δ: 0.21 (9H, s), 1.56 (9H, s), 3.58 (2H, d), 6.81 (1H, s), 7.36 (1H, d), 7.73-7.76 (4H, m), 8.02 (1H, s), 8.07 
               
               
                   
                 (1H, s). 
               
               
                   
               
            
           
         
       
     
     BIOLOGICAL TEST EXAMPLE 1 
     Test on  Spodoptera litura  Larvae 
     Solvent: Dimethylformamide, 3 parts by weight
 
Emulsifier: Polyoxyethylene alkylphenyl ether, 1 part by weight
 
     To prepare the test solution 1 part by weight of the active compound is mixed with the above-described amount of the solvent which contains the above-described amount of emulsifier. The resulting mixture is diluted with water to a predetermined concentration. 
     Leaves of sweet potato were immersed in the test solution. The leaves are air-dried and placed in a petri dish (9 cm diameter). 10  Spodoptera litura  third instar larvae were released in the petri dish, which was then stored in a constant temperature room (25° C.). More sweet potato leaves were added after 2 and 4 days. 7 days after the release of the larvae mortality was calculated by counting the number of dead larvae. 100% means that all the larvae have been killed; 0% means that none of the larvae have been killed. In the present test, an average value was taken from the results obtained from 2 petri dishes for 1 group. 
     Compounds having the example nos. 1-50 and 1-58, known from WO2005/085216, showed a control efficacy with 100% mortality at an active compound concentration of 100 ppm. 
     The following compounds showed a control efficacy with 100% mortality at an active compound concentration of 100 ppm: 
     Example Nos.: 1-2, 1-10, 1-38, 1-44, 1-54, 1-56, 1-67, 1-69, 1-79, 1-80, 1-114, 1-121, 1-125, 1-126, 1-127, 1-129, 1-131, 1-132, 1-150, 1-211, 1-213, 1-223, 1-232, 1-235, 1-250, 1-255, 1-259, 1-264, 1-271, 1-272, 1-273, 1-295, 3-1, 3-3, 3-4, 3-6, 3-7, 3-8, 3-9, 3-23, 3-32, 3-39, 3-40, 3-42, 3-43, 3-44, 3-45, 3-48, 3-55, 3-57, 3-61, 3-73, 3-74, 3-81, 3-82, 3-88, 3-89, 3-90, 3-91, 3-92, 3-93, 3-95, 3-97, 3-98, 3-104, 3-106, 3-112, 3-140, 3-142, 3-143, 3-145, 3-166, 3-188, 3-191, 3-193, 3-211, 3-213, 3-217, 3-218, 3-219, 3-220, 3-221, 3-230, 3-235, 3-236, 3-238, 3-239, 3-241, 3-251, 3-253, 3-254, 3-256, 3-257, 3-258, 3-259, 3-261, 3-270, 3-302, 3-303, 3-304, 3-305, 3-306, 3-307, 3-320, 3-322, 3-323, 3-326, 3-355, 3-358, 3-361, 3-547, 3-549, 3-551, 3-637, 3-638, 3-641, 3-642, 3-643, 3-644, 3-645, 3-646, 3-649, 3-650, 3-652, 3-656, 3-659, 3-661, 3-663, 3-664, 3-782, 3-785, 3-829, 3-831, 3-832, 3-833, 3-835, 3-836, 3-837, 3-838, 3-839, 3-840, 3-841, 3-842, 3-843, 3-844, 3-845, 3-846, 3-847, 3-848, 3-849, 3-850, 3-851, 3-852, 3-853, 3-854, 3-855, 3-856, 3-858, 3-859, 3-862, 3-863, 3-864, 3-865, 3-866, 3-867, 3-868, 3-869, 3-870, 3-871, 3-872, 3-873, 3-874, 3-875, 3-876, 3-877, 3-878, 3-879, 3-880, 3-881, 3-882, 3-883, 3-884, 3-885, 3-886, 3-887, 3-888, 3-889, 3-890, 3-891, 3-892, 3-893, 3-894, 3-896, 3-897, 3-898, 3-899, 3-900, 3-902, 3-904, 3-916, 3-917, 3-918, 3-919. 
     Biological Test Example 2 
     Test on  Tetranychus urticae  (Spray Test) 
     The test solution has been prepared as described in biological test example 1. 50 to 100 adult  Tetranychus urticae  were placed on pinto bean leaves at true leaf stage having two main leaves that had been grown in a pot (6 cm diameter). After 1 day, a generous amount of the test solution which has been diluted with water to the predetermined concentration was sprayed thereto using a spray gun. 
     After keeping the pot in a green house for 7 days, acaricidal ratio was calculated. 100% means that all the mites have been killed; 0% means that none of the mites have been killed. 
     The compound having the example no. 1-58, known from WO2005/085216, showed a control efficacy with at least 98% mortality at an active compound concentration of 100 ppm. 
     The following compounds showed a control efficacy with at least 98% mortality at an active compound concentration of 100 ppm: 
     Example Nos.: 1-38, 1-44, 1-114, 1-127, 1-129, 1-132, 1-232, 1-235, 1-259, 1-264, 1-273, 3-3, 3-4, 3-6, 3-7, 3-8, 3-9, 3-23, 3-32, 3-39, 3-40, 3-42, 3-43, 3-44, 3-45, 3-48, 3-55, 3-57, 3-61, 3-70, 3-73, 3-74, 3-81, 3-82, 3-88, 3-89, 3-90, 3-91, 3-92, 3-93, 3-95, 3-97, 3-98, 3-106, 3-112, 3-142, 3-143, 3-145, 3-166, 3-188, 3-191, 3-193, 3-213, 3-216, 3-217, 3-218, 3-219, 3-220, 3-221, 3-230, 3-235, 3-236, 3-238, 3-239, 3-253, 3-254, 3-256, 3-257, 3-258, 3-259, 3-261, 3-270, 3-302, 3-303, 3-304, 3-305, 3-306, 3-307, 3-323, 3-326, 3-355, 3-358, 3-361, 3-549, 3-551, 3-642, 3-644, 3-661, 3-829, 3-832, 3-833, 3-835, 3-836, 3-838, 3-839, 3-840, 3-841, 3-842, 3-843, 3-844, 3-845, 3-846, 3-847, 3-848, 3-849, 3-850, 3-851, 3-852, 3-853, 3-854, 3-855, 3-856, 3-859, 3-862, 3-863, 3-864, 3-865, 3-866, 3-867, 3-868, 3-869, 3-870, 3-871, 3-872, 3-873, 3-874, 3-875, 3-876, 3-877, 3-878, 3-880, 3-881, 3-883, 3-884, 3-885, 3-886, 3-887, 3-888, 3-889, 3-890, 3-891, 3-892, 3-893, 3-895, 3-896, 3-897, 3-898, 3-899, 3-900, 3-902, 3-903, 3-917, 3-918, 3-919. 
     Biological Test Example 3 
     Test on  Aulacophora femoralis  (Spray Application) 
     The test solution has been prepared as described in biological test example 1. 
     Cucumber leaves were immersed in a test solution that had been diluted to a predetermined concentration with water. The leaves were air-dried and then put in a plastic cup containing sterilized black soil. 5  Aulacophora femoralis  second instar larvae were released in the cup. 7 days later, mortality was calculated by counting the number of dead larvae. 100% means that all larvae have been killed; 0% means that none of the larvae have been killed. 
     Compounds having the example nos. 1-50, 1-52, and 1-58, known from WO2005/085216, showed a control efficacy with 100% mortality at an active compound concentration of 100 ppm. 
     The following compounds showed a control efficacy with 100% mortality at an active compound concentration of 100 ppm: 
     Example Nos.: 1-2, 1-38, 1-44, 1-54, 1-61, 1-64, 1-80, 1-114, 1-115, 1-125, 1-127, 1-129, 1-131, 1-132, 1-142, 1-150, 1-151, 1-169, 1-221, 1-232, 1-251, 1-259, 1-264, 1-272, 1-273, 3-1, 3-3, 3-4, 3-6, 3-7, 3-8, 3-9, 3-23, 3-32, 3-39, 3-40, 3-42, 3-43, 3-44, 3-45, 3-48, 3-55, 3-57, 3-61, 3-73, 3-74, 3-81, 3-82, 3-88, 3-89, 3-90, 3-91, 3-92, 3-93, 3-95, 3-97, 3-98, 3-106, 3-112, 3-142, 3-143, 3-145, 3-166, 3-188, 3-191, 3-193, 3-211, 3-213, 3-217, 3-218, 3-220, 3-221, 3-230, 3-235, 3-236, 3-238, 3-239, 3-241, 3-253, 3-254, 3-256, 3-257, 3-258, 3-259, 3-261, 3-270, 3-302, 3-303, 3-304, 3-305, 3-306, 3-307, 3-323, 3-326, 3-358, 3-361, 3-547, 3-549, 3-551, 3-637, 3-638, 3-640, 3-642, 3-643, 3-644, 3-645, 3-646, 3-651, 3-652, 3-659, 3-663, 3-664, 3-779, 3-785, 3-829, 3-831, 3-832, 3-833, 3-835, 3-836, 3-837, 3-838, 3-839, 3-841, 3-842, 3-843, 3-844, 3-845, 3-846, 3-847, 3-848, 3-849, 3-850, 3-851, 3-852, 3-853, 3-854, 3-855, 3-856, 3-859, 3-862, 3-863, 3-864, 3-865, 3-866, 3-867, 3-868, 3-869, 3-870, 3-871, 3-872, 3-873, 3-874, 3-875, 3-876, 3-877, 3-878, 3-880, 3-881, 3-882, 3-883, 3-884, 3-885, 3-886, 3-887, 3-888, 3-889, 3-890, 3-891, 3-892, 3-893, 3-894, 3-895, 3-896, 3-897, 3-898, 3-899, 3-900, 3-901, 3-902, 3-903, 3-904, 3-917, 3-918, 3-919. 
     Biological Test Example 4 
       Musca domestica —Test 
     Solvent: dimethyl sulfoxide 
     To produce a suitable preparation of active compound, 10 mg of active compound are dissolved in 0.5 ml solvent, and the concentrate is diluted with water to the desired concentration. Prior to the assay, a piece or kitchen sponge is soaked with a mixture of sugar and compound solution and placed into a container. 10 adults ( Musca domestica ) are placed into the container and closed with a perforated lid. After 2 days, mortality in % is determined. 100% means that all the flies have been killed; 0% means that none of the flies have been killed. 
     Compounds having the example nos. 1-50, 1-52, and 1-58, known from WO2005/085216, showed good acitivity of ≧80% at application rate of 100 ppm. 
     In this test for example, the following compounds from the preparation examples showed good activity of ≧80% at application rate of 100 ppm: 
     Example Nos.: 1-2, 1-10, 1-38, 1-44, 1-54, 1-56, 1-61, 1-64, 1-80, 1-114, 1-125, 1-126, 1-129, 1-131, 1-132, 1-142, 1-211, 1-213, 1-232, 1-235, 1-255, 1-264, 1-271, 1-272, 3-3, 3-7, 3-9, 3-23, 3-32, 3-39, 3-40, 3-42, 3-43, 3-44, 3-45, 3-48, 3-55, 3-90, 3-91, 3-92, 3-93, 3-95, 3-106, 3-112, 3-213, 3-217, 3-218, 3-221, 3-230, 3-235, 3-236, 3-239, 3-253, 3-256, 3-257, 3-258, 3-259, 3-261, 3-270, 3-302, 3-304, 3-305, 3-320, 3-323, 3-326, 3-637, 3-638, 3-640, 3-641, 3-642, 3-643, 3-644, 3-645, 3-646, 3-651, 3-652, 3-656, 3-785, 3-829, 3-832, 3-833, 3-835, 3-836, 3-838, 3-844, 3-845, 3-846, 3-307, 3-847, 3-848, 3-851, 3-57, 3-849, 3-89, 3-303, 3-852, 3-4, 3-878, 3-8, 3-859, 3-862, 3-863, 3-864, 3-865, 3-74, 3-254, 3-917, 3-918, 3-880, 3-98, 3-881, 3-853, 3-868, 3-73, 3-897, 3-898, 3-97, 3-81, 3-872, 3-361, 3-355, 3-358. 
     Biological Test Example 5 
       Lucillia cuprina —Test 
     Solvent: dimethyl sulfoxide 
     To produce a suitable preparation of active compound, 10 mg of active compound are dissolved in 0.5 ml solvent, and the concentrate is diluted with water to the desired concentration. Approximately 20-30 (Lucilia cuprina larvae) are transferred into a test tube containing 1 cm 3  of minced horse meat and 0.5 ml aqueous dilution of test compound. After 2 days, mortality in % is determined. 100% means that all the larvae have been killed; 0% means that none of the larvae have been killed. 
     Compounds having the example nos. 1-50, 1-52 and 1-58, known from WO2005/085216, showed good activity of ≧80% at application rate of 100 ppm. 
     In this test for example, the following compounds from the preparation examples showed good activity of ≧80% at application rate of 100 ppm: 
     Example Nos.: 1-2, 1-10, 1-38, 1-44, 1-54, 1-56, 1-61, 1-64, 1-67, 1-69, 1-79, 1-80, 1-114, 1-116, 1-121, 1-125, 1-126, 1-129, 1-131, 1-132, 1-142, 1-150, 1-151, 1-155, 1-164, 1-211, 1-213, 1-232, 1-235, 1-241, 1-255, 1-264, 1-270, 1-271, 1-272, 3-3, 3-7, 3-9, 3-23, 3-32, 3-39, 3-40, 3-42, 3-43, 3-44, 3-45, 3-48, 3-55, 3-70, 3-90, 3-91, 3-92, 3-93, 3-95, 3-106, 3-112, 3-213, 3-216, 3-217, 3-218, 3-219, 3-221, 3-230, 3-235, 3-236, 3-239, 3-241, 3-253, 3-256, 3-257, 3-258, 3-259, 3-261, 3-270, 3-302, 3-304, 3-305, 3-320, 3-323, 3-326, 3-344, 3-637, 3-638, 3-640, 3-641, 3-642, 3-643, 3-644, 3-645, 3-646, 3-651, 3-652, 3-656, 3-659, 3-660, 3-661A, 3-663, 3-664, 3-785, 3-828, 3-829, 3-831, 3-832, 3-833, 3-835, 3-836, 3-838, 3-844, 3-845, 3-846, 3-307, 3-847, 3-848, 3-851, 3-57, 3-849, 3-89, 3-303, 3-852, 3-4, 3-878, 3-8, 3-859, 3-862, 3-863, 3-864, 3-865, 3-74, 3-254, 3-917, 3-918, 3-880, 3-98, 3-881, 3-853, 3-868, 3-73, 3-897, 3-898, 3-97, 3-81, 3-872, 3-361, 3-355, 3-358. 
     Biological Test Example 6 
       Ctenocephalides felis —Test 
     Solvent: dimethyl sulfoxide 
     To produce a suitable preparation of active compound, 10 mg of active compound are dissolved in 0.5 ml solvent, and the concentrate is diluted with cattle blood to the desired concentration. Approximately 10 to 15 adult unfed (Ctenocepahlides  felis ) are placed in flea chambers. The blood chamber, are sealed with parafilm on the bottom are filled with cattle blood supplied with compound solution and placed on top of the flea chamber, so that the fleas are able to suck the blood. The blood chamber is heated to 37° C. whereas the flea chamber is kept at room temperature. After 2 days, mortality in % is determined. 100% means that all the fleas have been killed; 0% means that none of the fleas have been killed. 
     Compounds having the example nos. 1-50, 1-52 and 1-58, known from WO2005/085216, showed good activity of ≧80% at application rate of 100 ppm. 
     In this test for example, the following compounds from the preparation examples showed good activity of ≧80% at application rate of 100 ppm: 
     Example Nos.: 1-2, 1-10, 1-38, 1-44, 1-54, 1-56, 1-61, 1-64, 1-67, 1-80, 1-114, 1-115, 1-121, 1-125, 1-126, -129, 1-131, 1-132, 1-150, 1-164, 1-232, 1-235, 1-255, 1-264, 1-271, 1-272, 3-3, 3-7, 3-9, 3-23, 3-32, 3-39, 3-40, 3-42, 3-43, 3-44, 3-45, 3-48, 3-55, 3-90, 3-91, 3-92, 3-93, 3-95, 3-106, 3-112, 3-213, 3-216, 3-217, 3-218, 3-221, 3-230, 3-235, 3-236, 3-239, 3-241, 3-253, 3-256, 3-257, 3-258, 3-259, 3-261, 3-270, 3-302, 3-304, 3-305, 3-320, 3-323, 3-326, 3-637, 3-638, 3-640, 3-641, 3-642, 3-643, 3-644, 3-645, 3-646, 3-651, 3-652, 3-656, 3-663, 3-785, 3-829, 3-831, 3-832, 3-833, 3-835, 3-836, 3-838, 3-844, 3-845, 3-846, 1-69, 3-307, 3-847, 3-848, 3-851, 3-57, 3-849, 3-89, 3-303, 3-852, 3-4, 3-878, 3-8, 3-859, 3-862, 3-863, 3-864, 3-865, 3-74, 3-254, 3-917, 3-918, 3-880, 3-98, 3-881, 3-853, 3-868, 3-73, 3-897, 3-898, 3-97, 3-81, 3-872, 3-361, 3-355, 3-358. 
     Biological Test Example 7 
       Boophilus microplus —Test (Injection) 
     Solvent: dimethyl sulfoxide 
     To produce a suitable preparation of active compound, 10 mg of active compound are dissolved in 0.5 ml solvent, and the concentrate is diluted with solvent to the desired concentration. Five adult engorged female ticks ( Boophilus microplus ) are injected with compound solution into the abdomen. Ticks are transferred into replica plates and incubated in a climate chamber for a period of time. Egg deposition of fertile eggs is monitored. After 7 days, mortality in % is determined. 100% means that all eggs are infertile; 0% means that all eggs are fertile. 
     Compounds having the example nos. 1-50, 1-52 and 1-58, known from WO2005/085216, showed good activity of ≧80% at application rate of 20 μg/animal. 
     In this test for example, the following compounds from the preparation examples showed good activity of ≧80% at application rate of 20 μg/animal: 
     Example Nos.:1-2, 1-10, 1-38, 1-44, 1-54, 1-56, 1-61, 1-64, 1-67, 1-69, 1-79, 1-80, 1-114, 1-115, 1-116, 1-121, 1-125, 1-126, 1-129, 1-131, 1-132, 1-142, 1-150, 1-151, 1-164, 1-169, 1-175, 1-211, 1-213, 1-232, 1-235, 1-241, 1-255, 1-264, 1-270, 1-271, 1-272, 3-3, 3-7, 3-9, 3-23, 3-32, 3-39, 3-40, 3-42, 3-43, 3-44, 3-45, 3-48, 3-55, 3-70, 3-90, 3-91, 3-92, 3-93, 3-95, 3-106, 3-112, 3-137, 3-138, 3-211, 3-213, 3-216, 3-217, 3-218, 3-219, 3-221, 3-230, 3-235, 3-236, 3-239, 3-241, 3-253, 3-254, 3-256, 3-257, 3-258, 3-259, 3-261, 3-270, 3-302, 3-304, 3-305, 3-320, 3-323, 3-326, 3-344, 3-637, 3-638, 3-640, 3-641, 3-642, 3-643, 3-644, 3-645, 3-646, 3-651, 3-652, 3-656, 3-659, 3-660, 3-661A, 3-663, 3-664, 3-785, 3-828, 3-829, 3-832, 3-833, 3-835, 3-836, 3-838, 3-844, 3-845, 3-846, 3-307, 3-847, 3-848, 3-851, 3-57, 3-849, 3-89, 3-303, 3-852, 3-4, 3-878, 3-8, 3-859, 3-862, 3-863, 3-864, 3-865, 3-74, 3-254, 3-917, 3-918, 3-880, 3-98, 3-881, 3-853, 3-868, 3-73, 3-897, 3-898, 3-97, 3-81, 3-872, 3-361, 3-355, 3-358. 
     Biological Test Example 8 
       Boophilus microplus —Test (Dip) 
     Solvent: dimethyl sulfoxide 
     To produce a suitable preparation of active compound, 10 mg of active compound are dissolved in 0.5 ml solvent, and the concentrate is diluted with water to the desired concentration. Eight to ten adult engorged female  Boophilus microplus  ticks are placed in perforated plastic beakers and immersed in aqueous compound solution for one minute. Ticks are transferred to a filter paper in a plastic tray. Egg deposition of fertile eggs is monitored after. After 7 days, mortality in % is determined. 100% means that all the ticks have been killed; 0% means that none of the ticks have been killed. 
     In this test for example, the following compounds from the preparation examples showed good activity of ≧80% at application rate of 100 ppm: 
     Example Nos.: 1-2, 1-38, 1-114, 3-3, 3-4, 3-7, 3-8, 3-9, 3-23, 3-39, 3-40, 3-42, 3-43, 3-44, 3-45, 3-48, 3-55, 3-57, 3-74, 3-89, 3-90, 3-91, 3-92, 3-93, 3-98, 3-106, 3-112, 3-213, 3-217, 3-218, 3-221, 3-235, 3-239, 3-253, 3-254, 3-256, 3-257, 3-258, 3-259, 3-261, 3-270, 3-305, 3-307, 3-323, 3-326, 3-358, 3-361, 3-785, 3-835, 3-836, 3-838, 3-844, 3-845, 3-846, 3-847, 3-849, 3-851, 3-852, 3-863, 3-864, 3-865, 3-878, 3-880, 3-881, 3-917, 3-307, 3-847, 3-851, 3-57, 3-849, 3-89, 3-852, 3-4, 3-878, 3-8, 3-863, 3-864, 3-865, 3-74, 3-254, 3-917, 3-880, 3-98, 3-881, 3-853, 3-868, 3-73, 3-897, 3-898, 3-97, 3-81, 3-872, 3-361, 3-358, 3-870, 3-887, 3-890, 3-874, 3-875, 3-876, 3-877, 3-142, 3-145. 
     Biological Test Example 9 
       Amblyomma Hebraeum —Test 
     Solvent: dimethyl sulfoxide 
     To produce a suitable preparation of active compound, 10 mg active compound is mixed with 0.5 ml solvent, and the concentrate is diluted with containing solvent to the desired concentration. Nymphs of the tick  Amblyomma hebraeum  are placed in perforated plastic beakers and immersed in aqueous compound solution for one minute. Ticks are transferred to a filter paper in a Petri dish and incubated in a climate chamber for 42 days. After the specified period of time, mortality in % is determined. 100% means that all the ticks have been killed; 0% means that none of the ticks have been killed. In this test for example, the following compounds from the preparation examples showed good activity of ≧80% at application rate of 100 ppm: 
     Example Nos.: 3-9, 3-39, 3-40, 3-90, 3-91, 3-93, 3-832, 3-833, 3-835, 3-836, 3-838 
     Biological Test Example 10 
       Phaedon cochleariae —Test (Spray Application) 
     Solvent: 78.0 parts by weight of acetone
         1.5 parts by weight of dimethylformamide
 
Emulsifier: 0.5 parts by weight of alkylaryl polyglycolether
       

     To produce a suitable preparation of active compound, 1 part by weight of active compound is mixed with the stated amount of solvent and emulsifier, and the concentrate is diluted with emulsifier-containing water to the desired concentration. Chinese cabbage ( Brassica pekinesis ) leaf-disks are sprayed with a preparation of the active ingredient of the desired concentration. Once dry, the leaf disks are infested with mustard beetle larvae ( Phaedon cochleariae ). 
     After 7 days, mortality in % is determined. 100% means that all beetle larvae have been killed and 0% means that none of the beetle larvae have been killed. In this test for example, the following compounds from the preparation examples showed good activity of 80% at application rate of 500 g/ha: 
     Example Nos.: 1-2, 1-209, 1-224, 4-3, 4-6,4-11, 4-17, 4-19, 4-41, 4-44, 4-48, 4-56, 4-57 
     BIOLOGICAL TEST EXAMPLE 11 
       Spodoptera frugiperda —Test (Spray Application) 
     Solvent: 78.0 parts by weight acetone
         1.5 parts by weight dimethylformamide
 
Wetting agent 0.5 parts by weight alkylarylpolyglcolether
       

     To produce a suitable preparation of the active compound, 1 part by weight of active compound is mixed with the stated amount of solvent and emulsifier, and the concentrate is dilutes with emulsifier-containing water to the desired concentration. 
     Maize ( Zea mais ) leaf sections are sprayed with a preparation of the active ingredient of the desired concentration. Once dry, the leaf sections are infested with fall armyworm larvae ( Spodoptera frugiperda ). After 7 days, mortality in % is determined. 100% means that all caterpillars have been killed and 0% means that none of the caterpillars have been killed. In this test for example, the following compounds from the preparation examples showed good activity of ≧80% at application rate of 500 g/ha: 
     Example Nos.: 1-2, 1-224, 4-3, 4-6, 4-11, 4-17, 4-19, 4-48 
     PREPARATION EXAMPLE 1 
     Granule Formulation 
     To a mixture including the compound of the present invention (Compound No. 1-2; 10 parts by weight), bentonite (montmorilonite; 30 parts by weight), talc (58 parts by weight) and lignin sulfonate (2 parts by weight), water (25 parts by weight) is added and the resulting mixture is kneaded well. By using an extrusive granulator, granules of 10 to 40 mesh are formed and a granule formulation is obtained after drying at 40 to 50° C. 
     PREPARATION EXAMPLE 2 
     Granule Formulation 
     Clay mineral having a size distribution in the range of 0.2-2 mm (95 parts by weight) is added to a rotary mixer. By spraying the compound of the present invention (Compound No. 1-2; 5 parts by weight) together with a liquid diluent under rotation, the clay is moistened followed by drying at 40 to 50° C. to obtain a granule formulation. 
     PREPARATION EXAMPLE 3 
     Emulsion 
     By mixing the compound of the present invention (Compound No. 1-2; 30 parts by weight), xylene (55 parts by weight), polyoxyethylene alkylphenyl ether (8 parts by weight) and calcium alkylbenzene slufonate (7 parts by weight) with stirring, an emulsion is obtained. 
     PREPARATION EXAMPLE 4 
     Wettable Agent 
     By mixing the compound of the present invention (Compound No. 1-2; 15 parts by weight), a mixture including white carbon (fine powders of hydrous non-crystalline silicon oxide) and powder clay (1:5 mixture; 80 parts by weight), and a condensate of sodium alkylnaphthalene sulfonate formalin (3 parts by weight) and sodium alkylbenzene slufonate (2 parts by weight) with pulverization, a wettable agent is obtained. 
     PREPARATION EXAMPLE 5 
     Wettable Granules 
     The compound of the present invention (Compound No. 1-2; 20 parts by weight), lignin sodium sulfonate (30 parts by weight), bentonite (15 parts by weight) and calcined diatomaceous earth powder (35 parts by weight) are thoroughly mixed. After adding water thereto, the mixture is extruded through 0.3 mm screen followed by drying to obtain wettable granules. 
     The novel pesticidal condensed-ring aryl derivatives of the present invention have an excellent pesticidal activity as shown in the biological examples.