Patent Publication Number: US-6660838-B1

Title: Compounds and methods for therapy and diagnosis of lung cancer

Description:
REFERENCE TO RELATED APPLICATIONS 
     This application is a continuation-in-part of U.S. patent application No. 09/123,912, filed Jul. 27, 1998, now U.S. Pat. No. 6,312,695, which is a continuation-in-part of U.S. patent application Ser. No. 09/040,802, filed Mar. 18, 1998, now abandoned. 
    
    
     TECHNICAL FIELD 
     The present invention relates generally to compositions and methods for the treatment and diagnosis of lung cancer. The invention is more specifically related to nucleotide sequences that are preferentially expressed in lung tumor tissue, together with polypeptides encoded by such nucleotide sequences. The inventive nucleotide sequences and polypeptides may be used in vaccines and pharmaceutical compositions for the treatment and diagnosis of lung cancer. 
     BACKGROUND OF THE INVENTION 
     Lung cancer is the primary cause of cancer death among both men and women in the U.S., with an estimated 172,000 new cases being reported in 1994. The five-year survival rate among all lung cancer patients, regardless of the stage of disease at diagnosis, is only 13%. This contrasts with a five-year survival rate of 46% among cases detected while the disease is still localized. However, only 16% of lung cancers are discovered before the disease has spread. 
     Early detection is difficult since clinical symptoms are often not seen until the disease has reached an advanced stage. Currently, diagnosis is aided by the use of chest x-rays, analysis of the type of cells contained in sputum and fiberoptic examination of the bronchial passages. Treatment regimens are determined by the type and stage of the cancer, and include surgery, radiation therapy and/or chemotherapy. In spite of considerable research into therapies for the disease, lung cancer remains difficult to treat. 
     Accordingly, there remains a need in the art for improved vaccines, treatment methods and diagnostic techniques for lung cancer. 
     SUMMARY OF THE INVENTION 
     Briefly stated, the present invention provides compounds and methods for the therapy of lung cancer. In a first aspect, isolated polynucleotide molecules encoding lung tumor polypeptides are provided, such polynucleotide molecules comprising a nucleotide sequence selected from the group consisting of: (a) sequences provided in SEQ ID NO: 1-3, 6-8, 10-13, 15-27, 29, 30, 32, 34-49, 51, 52, 54, 55, 57-59, 61-69, 71, 73, 74, 77, 78, 80-82, 84, 86-96, 107-109, 111, 113, 125, 127, 128, 129, 131-133, 142, 144, 148-151, 153, 154, 157, 158, and 160; (b) sequences complementary to a sequence provided in SEQ ID NO: 1-3, 6-8, 10-13, 15-27, 29, 30, 32, 34-49, 51, 52, 54, 55, 57-59, 61-69, 71, 73, 74, 77, 78, 80-82, 84, 86-96, 107-109, 111, 113, 125, 127, 128, 129, 131-133, 142, 144, 148-151, 153, 154, 157, 158, and 160; and (b) sequences that hybridize to a sequence of (a) or (b) under moderately stringent conditions. 
     In a second aspect, isolated polypeptides are provided that comprise at least an immunogenic portion of a lung tumor protein or a variant thereof. In specific embodiments, such polypeptides comprise an amino acid sequence encoded by a polynucleotide molecule comprising a nucleotide sequence selected from the group consisting of (a) sequences recited in SEQ ID NO: 1-3, 6-8, 10-13, 15-27, 29, 30, 32, 34-49, 51, 52, 54, 55, 57-59, 61-69, 71, 73, 74, 77, 78, 80-82, 84, 86-96, 107-109, 111, 113, 125, 127, 128, 129, 131-133, 142, 144, 148-151, 153, 154, 157, 158, and 160; (b) sequences complementary to a sequence provided in SEQ ID NO: 1-3, 6-8, 10-13, 15-27, 29, 30, 32, 34-49, 51, 52, 54, 55, 57-59, 61-69, 71, 73, 74, 77, 78, 80-82, 84, 86-96, 107-109, 111, 113, 125, 127, 128, 129, 131-133, 142, 144, 148-151, 153, 154, 157, 158, and 160; and (c) sequences that hybridize to a sequence of (a) or (b) under moderately stringent conditions. 
     In related aspects, expression vectors comprising the inventive polynucleotide molecules, together with host cells transformed or transfected with such expression vectors are provided. In preferred embodiments, the host cells are selected from the group consisting of  E. Coli , yeast and mammalian cells. 
     In another aspect, fusion proteins comprising a first and a second inventive polypeptide or, alternatively, an inventive polypeptide and a known lung tumor antigen, are provided. 
     The present invention further provides pharmaceutical compositions comprising one or more of the above polypeptides, fusion proteins or polynucleotide molecules and a physiologically acceptable carrier, together with vaccines comprising one or more such polypeptides, fusion proteins or polynucleotide molecules in combination with an immune response enhancer. 
     In related aspects, the present invention provides methods for inhibiting the development of lung cancer in a patient, comprising administering to a patient an effective amount of at least one of the above pharmaceutical compositions and/or vaccines. 
     Additionally, the present invention provides methods for immunodiagnosis of lung cancer, together with kits for use in such methods. Polypeptides are disclosed which comprise at least an immunogenic portion of a lung tumor protein or a variant of said protein that differs only in conservative substitutions and/or modifications, wherein the lung tumor protein comprises an amino acid sequence encoded by a polynucleotide molecule having a sequence selected from the group consisting of nucleotide sequences recited in SEQ ID NO: 1-109, 111, 113, 115-151, 153, 154, 157, 158, and 160, and variants thereof. Such polypeptides may be usefully employed in the diagnosis and monitoring of lung cancer. 
     In one specific aspect of the present invention, methods are provided for detecting lung cancer in a patient, comprising: (a) contacting a biological sample obtained from a patient with a binding agent that is capable of binding to one of the above polypeptides; and (b) detecting in the sample a protein or polypeptide that binds to the binding agent. In preferred embodiments, the binding agent is an antibody, most preferably a monoclonal antibody. 
     In related aspects, methods are provided for monitoring the progression of lung cancer in a patient, comprising: (a) contacting a biological sample obtained from a patient with a binding agent that is capable of binding to one of the above polypeptides; (b) determining in the sample an amount of a protein or polypeptide that binds to the binding agent; (c) repeating steps (a) and (b); and comparing the amounts of polypeptide detected in steps (b) and (c). 
     Within related aspects, the present invention provides antibodies, preferably monoclonal antibodies, that bind to the inventive polypeptides, as well as diagnostic kits comprising such antibodies, and methods of using such antibodies to inhibit the development of lung cancer. 
     The present invention further provides methods for detecting lung cancer comprising: (a) obtaining a biological sample from a patient; (b) contacting the sample with a first and a second oligonucleotide primer in a polymerase chain reaction, at least one of the oligonucleotide primers being specific for a polynucleotide molecule that encodes one of the above polypeptides; and (c) detecting in the sample a polynucleotide sequence that amplifies in the presence of the first and second oligonucleotide primers. In a preferred embodiment, at least one of the oligonucleotide primers comprises at least about 10 contiguous nucleotides of a polynucleotide molecule including a sequence selected from the group consisting of SEQ ID NO: 1-109, 111, 113, 115-151, 153, 154, 157, 158, and 160. 
     In a further aspect, the present invention provides a method for detecting lung cancer in a patient comprising: (a) obtaining a biological sample from the patient; (b) contacting the sample with an oligonucleotide probe specific for a polynucleotide molecule that encodes one of the above polypeptides; and (c) detecting in the sample a polynucleotide sequence that hybridizes to the oligonucleotide probe. Preferably, the oligonucleotide probe comprises at least about 15 contiguous nucleotides of a polynucleotide molecule having a partial sequence selected from the group consisting of SEQ ID NO: 1-109, 111, 113, 115-151, 153, 154, 157, 158, and 160. 
     In related aspects, diagnostic kits comprising the above oligonucleotide probes or primers are provided. 
     In yet a further aspect, methods for the treatment of lung cancer in a patient are provided, the methods comprising obtaining PBMC from the patient, incubating the PBMC with a polypeptide of the present invention (or a polynucleotide that encodes such a polypeptide) to provide incubated T cells and administering the incubated T cells to the patient. The present invention additionally provides methods for the treatment of lung cancer that comprise incubating antigen presenting cells with a polypeptide of the present invention (or a polynucleotide that encodes such a polypeptide) to provide incubated antigen presenting cells and administering the incubated antigen presenting cells to the patient. In certain embodiments, the antigen presenting cells are selected from the group consisting of dendritic cells and macrophages. Compositions for the treatment of lung cancer comprising T cells or antigen presenting cells that have been incubated with a polypeptide or polynucleotide of the present invention are also provided. These and other aspects of the present invention will become apparent upon reference to the following detailed description. All references disclosed herein are hereby incorporated by reference in their entirety as if each was incorporated individually. 
     DETAILED DESCRIPTION OF THE INVENTION 
     As noted above, the present invention is generally directed to compositions and methods for the therapy and diagnosis of lung cancer. The compositions described herein include polypeptides, fusion proteins and polynucleotide molecules. Also included within the present invention are molecules (such as an antibody or fragment thereof) that bind to the inventive polypeptides. Such molecules are referred to herein as “binding agents.” 
     In one aspect, the subject invention discloses polypeptides comprising an immunogenic portion of a human lung tumor protein, wherein the lung tumor protein includes an amino acid sequence encoded by a polynucleotide molecule including a sequence selected from the group consisting of (a) nucleotide sequences recited in SEQ ID NO: 1-109, 111, 113 115-151, 153, 154, 157, 158, and 160, (b) the complements of said nucleotide sequences, and (c) variants of such sequences. As used herein, the term “polypeptide” encompasses amino acid chains of any length, including full length proteins, wherein the amino acid residues are linked by covalent peptide bonds. Thus, a polypeptide comprising a portion of one of the above lung tumor proteins may consist entirely of the portion, or the portion may be present within a larger polypeptide that contains additional sequences. The additional sequences may be derived from the native protein or may be heterologous, and such sequences may (but need not) be immunoreactive and/or antigenic. As detailed below, such polypeptides may be isolated from lung tumor tissue or prepared by synthetic or recombinant means. 
     As used herein, an “immunogenic portion” of a lung tumor protein is a portion that is capable of eliciting an immune response in a patient inflicted with lung cancer and as such binds to antibodies present within sera from a lung cancer patient. Such immunogenic portions generally comprise at least about 5 amino acid residues, more preferably at least about 10, and most preferably at least about 20 amino acid residues. Immunogenic portions of the proteins described herein may be identified in antibody binding assays. Such assays may generally be performed using any of a variety of means known to those of ordinary skill in the art, as described, for example, in Harlow and Lane,  Antibodies. A Laboratory Manual , Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y., 1988. For example, a polypeptide may be immobilized on a solid support (as described below) and contacted with patient sera to allow binding of antibodies within the sera to the immobilized polypeptide. Unbound sera may then be removed and bound antibodies detected using, for example,  125 I-labeled Protein A. Alternatively, a polypeptide may be used to generate monoclonal and polyclonal antibodies for use in detection of the polypeptide in blood or other fluids of lung cancer patients. Methods for preparing and identifying immunogenic portions of antigens of known sequence are well known in the art and include those summarized in Paul,  Fundamental Immunology , 3 rd  ed., Raven Press, 1993, pp. 243-247. 
     The term “polynucleotide(s),” as used herein, means a single or double-stranded polymer of deoxyribonucleotide or ribonucleotide bases and includes DNA and corresponding RNA molecules, including HnRNA and mRNA molecules, both sense and anti-sense strands, and comprehends cDNA, genomic DNA and recombinant DNA, as well as wholly or partially synthesized polynucleotides. An HnRNA molecule contains introns and corresponds to a DNA molecule in a generally one-to-one manner. An mRNA molecule corresponds to an HnRNA and DNA molecule from which the introns have been excised. A polynucleotide may consist of an entire gene, or any portion thereof Operable anti-sense polynucleotides may comprise a fragment of the corresponding polynucleotide, and the definition of “polynucleotide” therefore includes all such operable anti-sense fragments. 
     The compositions and methods of the present invention also encompass variants of the above polypeptides and polynucleotides. A polypeptide “variant,” as used herein, is a polypeptide that differs from the recited polypeptide only in conservative substitutions and/or modifications, such that the therapeutic, antigenic and/or immunogenic properties of the polypeptide are retained. In a preferred embodiment, variant polypeptides differ from an identified sequence by substitution, deletion or addition of five amino acids or fewer. Such variants may generally be identified by modifying one of the above polypeptide sequences, and evaluating the antigenic properties of the modified polypeptide using, for example, the representative procedures described herein. Polypeptide variants preferably exhibit at least about 70%, more preferably at least about 90% and most preferably at least about 95% identity (determined as describe below) to the identified polypeptides. 
     As used herein, a “conservative substitution” is one in which an amino acid is substituted for another amino acid that has similar properties, such that one skilled in the art of peptide chemistry would expect the secondary structure and hydropathic nature of the polypeptide to be substantially unchanged. In general, the following groups of amino acids represent conservative changes: (1) ala, pro, gly, glu, asp, gln, asn, ser, thr; (2) cys, ser, tyr, thr; (3) val, ile, leu, met, ala, phe; (4) lys, arg, his; and (5) phe, tyr, trp, his. 
     Variants may also, or alternatively, contain other modifications, including the deletion or addition of amino acids that have minimal influence on the antigenic properties, secondary structure and hydropathic nature of the polypeptide. For example, a polypeptide may be conjugated to a signal (or leader) sequence at the N-terminal end of the protein which co-translationally or post-translationally directs transfer of the protein. The polypeptide may also be conjugated to a linker or other sequence for ease of synthesis, purification or identification of the polypeptide (e.g., poly-His), or to enhance binding of the polypeptide to a solid support. For example, a polypeptide may be conjugated to an immunoglobulin Fc region. 
     A nucleotide “variant” is a sequence that differs from the recited nucleotide sequence in having one or more nucleotide deletions, substitutions or additions. Such modifications may be readily introduced using standard mutagenesis techniques, such as oligonucleotide-directed site-specific mutagenesis as taught, for example, by Adelman et al. ( DNA , 2:183, 1983). Nucleotide variants may be naturally occurring allelic variants, or non-naturally occurring variants. Variant nucleotide sequences preferably exhibit at least about 70%, more preferably at least about 80% and most preferably at least about 90% identity (determined as described below) to the recited sequence. 
     The antigens provided by the present invention include variants that are encoded by polynucleotide sequences which are substantially homologous to one or more of the polynucleotide sequences specifically recited herein. “Substantial homology,” as used herein, refers to polynucleotide sequences that are capable of hybridizing under moderately stringent conditions. Suitable moderately stringent conditions include prewashing in a solution of 5×SSC, 0.5% SDS, 1.0 mM EDTA (pH 8.0); hybridizing at 50° C.-65° C., 5×SSC, overnight or, in the event of cross-species homology, at 45° C. with 0.5×SSC; followed by washing twice at 65° C. for 20 minutes with each of 2×, 0.5× and 0.2×SSC containing 0.1% SDS. Such hybridizing polynucleotide sequences are also within the scope of this invention, as are nucleotide sequences that, due to code degeneracy, encode an immunogenic polypeptide that is encoded by a hybridizing polynucleotide sequence. 
     Two nucleotide or polypeptide sequences are said to be “identical” if the sequence of nucleotides or amino acid residues in the two sequences is the same when aligned for maximum correspondence as described below. Comparisons between two sequences are typically performed by comparing the sequences over a comparison window to identify and compare local regions of sequence similarity. A “comparison window” as used herein, refers to a segment of at least about 20 contiguous positions, usually 30 to about 75, 40 to about 50, in which a sequence may be compared to a reference sequence of the same number of contiguous positions after the two sequences are optimally aligned. 
     Optimal alignment of sequences for comparison may be conducted using the Megalign program in the Lasergene suite of bioinformatics software (DNASTAR, Inc., Madison, Wis.), using default parameters. This program embodies several alignment schemes described in the following references: Dayhoff, M. O. (1978) A model of evolutionary change in proteins—Matrices for detecting distant relationships. In Dayhoff, M. O. (ed.) Atlas of Protein Sequence and Structure, National Biomedical Resarch Foundaiton, Washington DC Vol. 5, Suppl. 3, pp. 345-358; Hein J. (1990) Unified Approach to Alignment and Phylogenes pp. 626-645  Methods in Enzymology  vol. 183, Academic Press, Inc., San Diego, Calif.; Higgins, D. G. and Sharp, P. M. (1989) Fast and sensitive multiple sequence alignments on a microcomputer  CABIOS  5:151-153; Myers, E. W. and Muller W. (1988) Optimal alignments in linear space  CABIOS  4:11-17; Robinson, E. D. (1971)  Comb. Theor  11:105; Santou, N. Nes, M. (1987) The neighbor joining method. A new method for reconstructing phylogenetic trees  Mol. Biol. Evol . 4:406-425; Sneath, P. H. A. and Sokal, R. R. (1973)  Numerical Taxonomy—the Principles and Practice of Numerical Taxonomy , Freeman Press, San Francisco, Calif.; Wilbur, W. J. and Lipman, D. J. (1983) Rapid similarity searches of nucleic acid and protein data banks  Proc. Natl. Acad, Sci. USA  80:726-730. 
     Preferably, the “percentage of sequence identity” is determined by comparing two optimally aligned sequences over a window of comparison of at least 20 positions, wherein the portion of the polynucleotide sequence in the comparison window may comprise additions or deletions (i.e. gaps) of 20 percent or less, usually 5 to 15 percent, or 10 to 12 percent, as compared to the reference sequences (which does not comprise additions or deletions) for optimal alignment of the two sequences. The percentage is calculated by determining the number of positions at which the identical nucleic acid bases or amino acid residue occurs in both sequences to yield the number of matched positions, dividing the number of matched positions by the total number of positions in the reference sequence (i.e. the window size) and multiplying the results by 100 to yield the percentage of sequence identity. 
     Also included in the scope of the present invention are alleles of the genes encoding the nucleotide sequences recited in herein. As used herein, an “allele” or “allellic sequence” is an alternative form of the gene which may result from at least one mutation in the nucleic acid sequence. Alleles may result in altered mRNAs or polypeptides whose structure or function may or may not be altered. Any given gene may have none, one, or many allelic forms. Common mutational changes which give rise to alleles are generally ascribed to natural deletions, additions, or substitutions of nucleotides. Each of these types of changes may occur alone or in combination with the others, one or more times in a given sequence. 
     For lung tumor polypeptides with immunoreactive properties, variants may, alternatively, be identified by modifying the amino acid sequence of one of the above polypeptides, and evaluating the immunoreactivity of the modified polypeptide. For lung tumor polypeptides useful for the generation of diagnostic binding agents, a variant may be identified by evaluating a modified polypeptide for the ability to generate antibodies that detect the presence or absence of lung cancer. Such modified sequences may be prepared and tested using, for example, the representative procedures described herein. 
     The lung tumor polypeptides of the present invention, and polynucleotide molecules encoding such polypeptides, may be isolated from lung tumor tissue using any of a variety of methods well known in the art. Polynucleotide sequences corresponding to a gene (or a portion thereof) encoding one of the inventive lung tumor proteins may be isolated from a lung tumor cDNA library using a subtraction technique as described in detail below. Examples of such polynucleotide sequences are provided in SEQ ID NO: 1-109, 111, 113 115-151, 153, 154, 157, 158, and 160. Partial polynucleotide sequences thus obtained may be used to design oligonucleotide primers for the amplification of full-length polynucleotide sequences from a human genomic DNA library or from a lung tumor cDNA library in a polymerase chain reaction (PCR), using techniques well known in the art (see, for example, Mullis et al.,  Cold Spring Harbor Symp. Quant. Biol . 51:263, 1987; Erlich ed.,  PCR Technology , Stockton Press, NY, 1989). For this approach, sequence-specific primers may be designed based on the nucleotide sequences provided herein and may be purchased or synthesized. 
     Once a polynucleotide sequence encoding a polypeptide is obtained, the polypeptide may be produced recombinantly by inserting the polynucleotide sequence into an expression vector and expressing the polypeptide in an appropriate host. Any of a variety of expression vectors known to those of ordinary skill in the art may be employed to express recombinant polypeptides of this invention. Expression may be achieved in any appropriate host cell that has been transformed or transfected with an expression vector containing a polynucleotide molecule that encodes the recombinant polypeptide. Suitable host cells include prokaryotes, yeast, insect and higher eukaryotic cells. Preferably, the host cells employed are  E. coli , yeast or a mammalian cell line, such as COS or CHO cells. The polynucleotide sequences expressed in this manner may encode naturally occurring polypeptides, portions of naturally occurring polypeptides, or other variants thereof. Supernatants from suitable host/vector systems which secrete the recombinant polypeptide may first be concentrated using a commercially available filter. The concentrate may then be applied to a suitable purification matrix, such as an affinity matrix or ion exchange resin. Finally, one or more reverse phase HPLC steps can be employed to further purify the recombinant polypeptide. 
     The lung tumor polypeptides disclosed herein may also be generated by synthetic means. In particular, synthetic polypeptides having fewer than about 100 amino acids, and generally fewer than about 50 amino acids, may be generated using techniques well known to those of ordinary skill in the art. For example, such polypeptides may be synthesized using any of the commercially available solid-phase techniques, such as the Merrifield solid-phase synthesis method, where amino acids are sequentially added to a growing amino acid chain (see, for example, Merrifield,  J Am. Chem. Soc . 85:2149-2146, 1963). Equipment for automated synthesis of polypeptides is commercially available from suppliers such as Perkin Elmer/Applied BioSystems Division (Foster City, Calif.), and may be operated according to the manufacturer&#39;s instructions. 
     In general, regardless of the method of preparation, the polypeptides disclosed herein are prepared in an isolated, substantially pure form (i.e., the polypeptides are homogenous as determined by amino acid composition and primary sequence analysis). Preferably, the polypeptides are at least about 90% pure, more preferably at least about 95% pure and most preferably at least about 99% pure. In certain preferred embodiments, described in more detail below, the substantially pure polypeptides are incorporated into pharmaceutical compositions or vaccines for use in one or more of the methods disclosed herein. 
     In a related aspect, the present invention provides fusion proteins comprising a first and a second inventive polypeptide or, alternatively, a polypeptide of the present invention and a known lung tumor antigen, together with variants of such fusion proteins. The fusion proteins of the present invention may (but need not) include a linker peptide between the first and second polypeptides. 
     A polynucleotide sequence encoding a fusion protein of the present invention is constructed using known recombinant DNA techniques to assemble separate polynucleotide sequences encoding the first and second polypeptides into an appropriate expression vector. The 3′ end of a DNA sequence encoding the first polypeptide is ligated, with or without a peptide linker, to the 5′ end of a DNA sequence encoding the second polypeptide so that the reading frames of the sequences are in phase to permit mRNA translation of the two DNA sequences into a single fusion protein that retains the biological activity of both the first and the second polypeptides. 
     A peptide linker sequence may be employed to separate the first and the second polypeptides by a distance sufficient to ensure that each polypeptide folds into its secondary and tertiary structures. Such a peptide linker sequence is incorporated into the fusion protein using standard techniques well known in the art. Suitable peptide linker sequences may be chosen based on the following factors: (1) their ability to adopt a flexible extended conformation; (2) their inability to adopt a secondary structure that could interact with functional epitopes on the first and second polypeptides; and (3) the lack of hydrophobic or charged residues that might react with the polypeptide functional epitopes. Preferred peptide linker sequences contain Gly, Asn and Ser residues. Other near neutral amino acids, such as Thr and Ala may also be used in the linker sequence. Amino acid sequences which may be usefully employed as linkers include those disclosed in Maratea et al., Gene 40:39-46, 1985; Murphy et al.,  Proc. Natl. Acad Sci. USA  83:8258-8262, 1986; U.S. Pat. No. 4,935,233 and U.S. Pat. No. 4,751,180. The linker sequence may be from 1 to about 50 amino acids in length. Peptide sequences are not required when the first and second polypeptides have non-essential N-terminal amino acid regions that can be used to separate the functional domains and prevent steric interference. 
     The ligated polynucleotide sequences are operably linked to suitable transcriptional or translational regulatory elements. The regulatory elements responsible for expression of polynucleotide are located only 5′ to the DNA sequence encoding the first polypeptides. Similarly, stop codons require to end translation and transcription termination signals are only present 3′ to the DNA sequence encoding the second polypeptide. 
     Fusion proteins are also provided that comprise a polypeptide of the present invention together with an unrelated immunogenic protein. Preferably the immunogenic protein is capable of eliciting a recall response. Examples of such proteins include tetanus, tuberculosis and hepatitis proteins (see, for example, Stoute et al.  New Engl. J Med ., 336:86-91 (1997)). 
     Polypeptides of the present invention that comprise an immunogenic portion of a lung tumor protein may generally be used for therapy of lung cancer, wherein the polypeptide stimulates the patient&#39;s own immune response to lung tumor cells. The present invention thus provides methods for using one or more of the compounds described herein (which may be polypeptides, polynucleotide molecules or fusion proteins) for immunotherapy of lung cancer in a patient. As used herein, a “patient” refers to any warm-blooded animal, preferably a human. A patient may be afflicted with disease, or may be free of detectable disease. Accordingly, the compounds disclosed herein may be used to treat lung cancer or to inhibit the development of lung cancer. The compounds are preferably administered either prior to or following surgical removal of primary tumors and/or treatment by administration of radiotherapy and conventional chemotherapeutic drugs. 
     In these aspects, the inventive polypeptide is generally present within a pharmaceutical composition or a vaccine. Pharmaceutical compositions may comprise one or more polypeptides, each of which may contain one or more of the above sequences (or variants thereof), and a physiologically acceptable carrier. The vaccines may comprise one or more such polypeptides and a non-specific immune-response enhancer, wherein the non-specific immune response enhancer is capable of eliciting or enhancing an immune response to an exogenous antigen. Examples of non-specific-immune response enhancers include adjuvants, biodegradable microspheres (e.g., polylactic galactide) and liposomes (into which the polypeptide is incorporated). Pharmaceutical compositions and vaccines may also contain other epitopes of lung tumor antigens, either incorporated into a fusion protein as described above (i.e., a single polypeptide that contains multiple epitopes) or present within a separate polypeptide. 
     Alternatively, a pharmaceutical composition or vaccine may contain polynucleotide encoding one or more of the above polypeptides and/or fusion proteins, such that the polypeptide is generated in situ. In such pharmaceutical compositions and vaccines, the polynucleotide may be present within any of a variety of delivery systems known to those of ordinary skill in the art, including nucleic acid expression systems, bacteria and viral expression systems. Appropriate nucleic acid expression systems contain the necessary polynucleotide sequences for expression in the patient (such as a suitable promoter). Bacterial delivery systems involve the administration of a bacterium (such as  Bacillus-Calmette-Guerrin ) that expresses an epitope of a lung cell antigen on its cell surface. In a preferred embodiment, the polynucleotides may be introduced using a viral expression system (e.g., vaccinia or other pox virus, retrovirus, or adenovirus), which may involve the use of a non-pathogenic (defective), replication competent virus. Suitable systems are disclosed, for example, in Fisher-Hoch et al.,  PNAS  86:317-321, 1989; Flexner et al.,  Ann. N.Y. Acad Sci . 569:86-103, 1989; Flexner et al.,  Vaccine  8:17-21, 1990; U.S. Pat. Nos. 4,603,112, 4,769,330, and 5,017,487; WO89/01973; U.S. Pat. No. 4,777,127; GB 2,200,651; EP 0,345,242; WO 91/02805; Berkner,  Biotechniques  6:616-627, 1988; Rosenfeld et al.,  Science  252:431-434, 1991; Kolls et al., PNAS 91:215-219, 1994; Kass-Eisler et al., PNAS 90:11498-11502, 1993; Guzman et al.,  Circulation  88:2838-2848, 1993; and Guzman et al.,  Cir. Res . 73:1202-1207, 1993. Techniques for incorporating polynucleotide into such expression systems are well known to those of ordinary skill in the art. The polynucleotides may also be “naked,” as described, for example, in published PCT application WO 90/11092, and Ulmer et al.,  Science  259:1745-1749, 1993, reviewed by Cohen,  Science  259:1691-1692, 1993. The uptake of naked polynucleotides may be increased by coating the polynucleotides onto biodegradable beads, which are efficiently transported into the cells. 
     Routes and frequency of administration, as well as dosage, will vary from individual to individual and may parallel those currently being used in immunotherapy of other diseases. In general, the pharmaceutical compositions and vaccines may be administered by injection (e.g., intracutaneous, intramuscular, intravenous or subcutaneous), intranasally (e.g., by aspiration) or orally. Between 1 and 10 doses may be administered over a 3-24 week period. Preferably, 4 doses are administered, at an interval of 3 months, and booster administrations may be given periodically thereafter. Alternate protocols may be appropriate for individual patients. A suitable dose is an amount of polypeptide or polynucleotide that is effective to raise an immune response (cellular and/or humoral) against lung tumor cells in a treated patient. A suitable immune response is at least 10-50% above the basal (i.e., untreated) level. In general, the amount of polypeptide present in a dose (or produced in situ by the polynucleotide molecule(s) in a dose) ranges from about 1 pg to about 100 mg per kg of host, typically from about 10 μg to about 1 μg, and preferably from about 100 μg to about 1 μg. Suitable dose sizes will vary with the size of the patient, but will typically range from about 0.01 mL to about 5 mL. 
     While any suitable carrier known to those of ordinary skill in the art may be employed in the pharmaceutical compositions of this invention, the type of carrier will vary depending on the mode of administration. For parenteral administration, such as subcutaneous injection, the carrier preferably comprises water, saline, alcohol, a lipid, a wax and/or a buffer. For oral administration, any of the above carriers or a solid carrier, such as mannitol, lactose, starch, magnesium stearate, sodium saccharine, talcum, cellulose, glucose, sucrose, and/or magnesium carbonate, may be employed. Biodegradable microspheres (e.g., polylactic glycolide) may also be employed as carriers for the pharmaceutical compositions of this invention. Suitable biodegradable microspheres are disclosed, for example, in U.S. Pat. Nos. 4,897,268 and 5,075,109. 
     Any of a variety of immune-response enhancers may be employed in the vaccines of this invention. For example, an adjuvant may be included. Most adjuvants contain a substance designed to protect the antigen from rapid catabolism, such as aluminum hydroxide or mineral oil, and a nonspecific stimulator of immune response, such as lipid A,  Bordella pertussis  or  Mycobacterium tuberculosis . Such adjuvants are commercially available as, for example, Freund&#39;s Incomplete Adjuvant and Complete Adjuvant (Difco Laboratories, Detroit, Mich.) and Merck Adjuvant 65 (Merck and Company, Inc., Rahway, N.J.). 
     Polypeptides disclosed herein may also be employed in adoptive immunotherapy for the treatment of cancer. Adoptive immunotherapy may be broadly classified into either active or passive immunotherapy. In active immunotherapy, treatment relies on the in vivo stimulation of the endogenous host immune system to react against tumors with the administration of immune response-modifying agents (for example, tumor vaccines, bacterial adjuvants, and/or cytokines). 
     In passive immunotherapy, treatment involves the delivery of biologic reagents with established tumor-immune reactivity (such as effector cells or antibodies) that can directly or indirectly mediate antitumor effects and does not necessarily depend on an intact host immune system. Examples of effector cells include T lymphocytes (for example, CD8+ cytotoxic T-lymphocyte, CD4+ T-helper, tumor-infiltrating lymphocytes), killer cells (such as Natural Killer cells, lymphokine-activated killer cells), B cells, or antigen presenting cells (such as dendritic cells and macrophages) expressing the disclosed antigens. The polypeptides disclosed herein may also be used to generate antibodies or anti-idiotypic antibodies (as in U.S. Pat. No. 4,918,164), for passive immunotherapy. 
     The predominant method of procuring adequate numbers of T-cells for adoptive immunotherapy is to grow immune T-cells in vitro. Culture conditions for expanding single antigen-specific T-cells to several billion in number with retention of antigen recognition in vivo are well known in the art. These in vitro culture conditions typically utilize intermittent stimulation with antigen, often in the presence of cytokines, such as IL-2, and non-dividing feeder cells. As noted above, the immunoreactive polypeptides described herein may be used to rapidly expand antigen-specific T cell cultures in order to generate sufficient number of cells for immunotherapy. In particular, antigen-presenting cells, such as dendritic, macrophage or B-cells, may be pulsed with immunoreactive polypeptides or transfected with a polynucleotide sequence(s), using standard techniques well known in the art. For example, antigen presenting cells may be transfected with a polynucleotide sequence, wherein said sequence contains a promoter region appropriate for increasing expression, and can be expressed as part of a recombinant virus or other expression system. For cultured T-cells to be effective in therapy, the cultured T-cells must be able to grow and distribute widely and to survive long term in vivo. Studies have demonstrated that cultured T-cells can be induced to grow in vivo and to survive long term in substantial numbers by repeated stimulation with antigen supplemented with IL-2 (see, for example, Cheever, M., et al, “Therapy With Cultured T Cells: Principles Revisited,”  Immunological Reviews , 157:177, 1997). 
     The polypeptides disclosed herein may also be employed to generate and/or isolate tumor-reactive T-cells, which can then be administered to the patient. In one technique, antigen-specific T-cell lines may be generated by in vivo immunization with short peptides corresponding to immunogenic portions of the disclosed polypeptides. The resulting antigen specific CD8+ CTL clones may be isolated from the patient, expanded using standard tissue culture techniques, and returned to the patient. 
     Alternatively, peptides corresponding to immunogenic portions of the polypeptides may be employed to generate tumor reactive T cell subsets by selective in vitro stimulation and expansion of autologous T cells to provide antigen-specific T cells which may be subsequently transferred to the patient as described, for example, by Chang et al. ( Crit. Rev. Oncol. Hematol ., 22(3), 213, 1996). Cells of the immune system, such as T cells, may be isolated from the peripheral blood of a patient, using a commercially available cell separation system, such as CelIPro Incorporated&#39;s (Bothell, WA) CEPRATE™ system (see U.S. Pat. No. 5,240,856; U.S. Pat. No. 5,215,926; WO 89/06280; WO 91/16116 and WO 92/07243). The separated cells are stimulated with one or more of the immunoreactive polypeptides contained within a delivery vehicle, such as a microsphere, to provide antigen-specific T cells. The population of tumor antigen-specific T cells is then expanded using standard techniques and the cells are administered back to the patient. 
     In another embodiment, T-cell and/or antibody receptors specific for the polypeptides can be cloned, expanded, and transferred into other vectors or effector cells for use in adoptive immunotherapy. 
     In a further embodiment, syngeneic or autologous dendritic cells may be pulsed with peptides corresponding to at least an immunogenic portion of a polypeptide disclosed herein. The resulting antigen-specific dendritic cells may either be transferred into a patient, or employed to stimulate T cells to provide antigen-specific T cells which may, in turn, be administered to a patient. The use of peptide-pulsed dendritic cells to generate antigen-specific T cells and the subsequent use of such antigen-specific T cells to eradicate tumors in a murine model has been demonstrated by Cheever et al,  Immunological Reviews , 157:177,1997), 
     Additionally, vectors expressing the disclosed polynucleotides may be introduced into stem cells taken from the patient and clonally propagated in vitro for autologous transplant back into the same patient. Polypeptides and fusion proteins of the present invention may also, or alternatively, be used to generate binding agents, such as antibodies or fragments thereof, that are capable of detecting metastatic human lung tumors. Binding agents of the present invention may generally be prepared using methods known to those of ordinary skill in the art, including the representative procedures described herein. Binding agents are capable of differentiating between patients with and without lung cancer, using the representative assays described herein. In other words, antibodies or other binding agents raised against a lung tumor protein, or a suitable portion thereof, will generate a signal indicating the presence of primary or metastatic lung cancer in at least about 20% of patients afflicted with the disease, and will generate a negative signal indicating the absence of the disease in at least about 90% of individuals without primary or metastatic lung cancer. Suitable portions of such lung tumor proteins are portions that are able to generate a binding agent that indicates the presence of primary or metastatic lung cancer in substantially all (i.e., at least about 80%, and preferably at least about 90%) of the patients for which lung cancer would be indicated using the full length protein, and that indicate the absence of lung cancer in substantially all of those samples that would be negative when tested with full length protein. The representative assays described below, such as the two-antibody sandwich assay, may generally be employed for evaluating the ability of a binding agent to detect metastatic human lung tumors. 
     The ability of a polypeptide prepared as described herein to generate antibodies capable of detecting primary or metastatic human lung tumors may generally be evaluated by raising one or more antibodies against the polypeptide (using, for example, a representative method described herein) and determining the ability of such antibodies to detect such tumors in patients. This determination may be made by assaying biological samples from patients with and without primary or metastatic lung cancer for the presence of a polypeptide that binds to the generated antibodies. Such test assays may be performed, for example, using a representative procedure described below. Polypeptides that generate antibodies capable of detecting at least 20% of primary or metastatic lung tumors by such procedures are considered to be useful in assays for detecting primary or metastatic human lung tumors. Polypeptide specific antibodies may be used alone or in combination to improve sensitivity. 
     Polypeptides capable of detecting primary or metastatic human lung tumors may be used as markers for diagnosing lung cancer or for monitoring disease progression in patients. In one embodiment, lung cancer in a patient may be diagnosed by evaluating a biological sample obtained from the patient for the level of one or more of the above polypeptides, relative to a predetermined cut-off value. As used herein, suitable “biological samples” include blood, sera, urine and/or lung secretions. 
     The level of one or more of the above polypeptides may be evaluated using any binding agent specific for the polypeptide(s). A “binding agent,” in the context of this invention, is any agent (such as a compound or a cell) that binds to a polypeptide as described above. As used herein, “binding” refers to a noncovalent association between two separate molecules (each of which may be free (i.e., in solution) or present on the surface of a cell or a solid support), such that a “complex” is formed. Such a complex may be free or immobilized (either covalently or noncovalently) on a support material. The ability to bind may generally be evaluated by determining a binding constant for the formation of the complex. The binding constant is the value obtained when the concentration of the complex is divided by the product of the component concentrations. In general, two compounds are said to “bind” in the context of the present invention when the binding constant for complex formation exceeds about 10 3  Limol. The binding constant may be determined using methods well known to those of ordinary skill in the art. 
     Any agent that satisfies the above requirements may be a binding agent. For example, a binding agent may be a ribosome with or without a peptide component, an RNA molecule or a peptide. In a preferred embodiment, the binding partner is an antibody, or a fragment thereof Such antibodies may be polyclonal, or monoclonal. In addition, the antibodies may be single chain, chimeric, CDR-grafted or humanized. Antibodies may be prepared by the methods described herein and by other methods well known to those of skill in the art. 
     There are a variety of assay formats known to those of ordinary skill in the art for using a binding partner to detect polypeptide markers in a sample. See, e.g., Harlow and Lane,  Antibodies: A Laboratory Manual , Cold Spring Harbor Laboratory, 1988. In a preferred embodiment, the assay involves the use of binding partner immobilized on a solid support to bind to and remove the polypeptide from the remainder of the sample. The bound polypeptide may then be detected using a second binding partner that contains a reporter group. Suitable second binding partners include antibodies that bind to the binding partner/polypeptide complex. Alternatively, a competitive assay may be utilized, in which a polypeptide is labeled with a reporter group and allowed to bind to the immobilized binding partner after incubation of the binding partner with the sample. The extent to which components of the sample inhibit the binding of the labeled polypeptide to the binding partner is indicative of the reactivity of the sample with the immobilized binding partner. 
     The solid support may be any material known to those of ordinary skill in the art to which the antigen may be attached. For example, the solid support may. be a test well in a microtiter plate or a nitrocellulose or other suitable membrane. Alternatively, the support may be a bead or disc, such as glass, fiberglass, latex or a plastic material such as polystyrene or polyvinylchloride. The support may also be a magnetic particle or a fiber optic sensor, such as those disclosed, for example, in U.S. Pat. No. 5,359,681. The binding agent may be immobilized on the solid support using a variety of techniques known to those of skill in the art, which are amply described in the patent and scientific literature. In the context of the present invention, the term “immobilization” refers to both noncovalent association, such as adsorption, and covalent attachment (which may be a direct linkage between the antigen and functional groups on the support or may be a linkage by way of a cross-linking agent). Immobilization by adsorption to a well in a microtiter plate or to a membrane is preferred. In such cases, adsorption may be achieved by contacting the binding agent, in a suitable buffer, with the solid support for a suitable amount of time. The contact time varies with temperature, but is typically between about 1 hour and about 1 day. In general, contacting a well of a plastic microtiter plate (such as polystyrene or polyvinylchloride) with an amount of binding agent ranging from about 10 ng to about 10 μg, and preferably about 100 ng to about 1 μg, is sufficient to immobilize an adequate amount of binding agent. 
     Covalent attachment of binding agent to a solid support may generally be achieved by first reacting the support with a bifunctional reagent that will react with both the support and a functional group, such as a hydroxyl or amino group, on the binding agent. For example, the binding agent may be covalently attached to supports having an appropriate polymer coating using benzoquinone or by condensation of an aldehyde group on the support with an amine and an active hydrogen on the binding partner (see, e.g., Pierce Immunotechnology Catalog and Handbook, 1991, at A12-A13). 
     In certain embodiments, the assay is a two-antibody sandwich assay. This assay may be performed by first contacting an antibody that has been immobilized on a solid support, commonly the well of a microtiter plate, with the sample, such that polypeptides within the sample are allowed to bind to the immobilized antibody. Unbound sample is then removed from the immobilized polypeptide-antibody complexes and a second antibody (containing a reporter group) capable of binding to a different site on the polypeptide is added. The amount of second antibody that remains bound to the solid support is then determined using a method appropriate for the specific reporter group. 
     More specifically, once the antibody is immobilized on the support as described above, the remaining protein binding sites on the support are typically blocked. Any suitable blocking agent known to those of ordinary skill in the art, such as bovine serum albumin or Tween 20™ (Sigma Chemical Co., St. Louis, Mo.). The immobilized antibody is then incubated with the sample, and polypeptide is allowed to bind to the antibody. The sample may be diluted with a suitable diluent, such as phosphate-buffered saline (PBS) prior to incubation. In general, an appropriate contact time (i.e., incubation time) is that period of time that is sufficient to detect the presence of polypeptide within a sample obtained from an individual with lung cancer. Preferably, the contact time is sufficient to achieve a level of binding that is at least about 95% of that achieved at equilibrium between bound and unbound polypeptide. Those of ordinary skill in the art will recognize that the time necessary to achieve equilibrium may be readily determined by assaying the level of binding that occurs over a period of time. At room temperature, an incubation time of about 30 minutes is generally sufficient. 
     Unbound sample may then be removed by washing the solid support with an appropriate buffer, such as PBS containing 0.1% Tween 20™. The second antibody, which contains a reporter group, may then be added to the solid support. Preferred reporter groups include enzymes (such as horseradish peroxidase), substrates, cofactors, inhibitors, dyes, radionuclides, luminescent groups, fluorescent groups and biotin. The conjugation of antibody to reporter group may be achieved using standard methods known to those of ordinary skill in the art. 
     The second antibody is then incubated with the immobilized antibody-polypeptide complex for an amount of time sufficient to detect the bound polypeptide. An appropriate amount of time may generally be determined by assaying the level of binding that occurs over a period of time. Unbound second antibody is then removed and bound second antibody is detected using the reporter group. The method employed for detecting the reporter group depends upon the nature of the reporter group. For radioactive groups, scintillation counting or autoradiographic methods are generally appropriate. Spectroscopic methods may be used to detect dyes, luminescent groups and fluorescent groups. Biotin may be detected using avidin, coupled to a different reporter group (commonly a radioactive or fluorescent group or an enzyme). Enzyme reporter groups may generally be detected by the addition of substrate (generally for a specific period of time), followed by spectroscopic or other analysis of the reaction products. 
     To determine the presence or absence of lung cancer, the signal detected from the reporter group that remains bound to the solid support is generally compared to a signal that corresponds to a predetermined cut-off value. In one preferred embodiment, the cut-off value is the average mean signal obtained when the immobilized antibody is incubated with samples from patients without lung cancer. In general, a sample generating a signal that is three standard deviations above the predetermined cut-off value is considered positive for lung cancer. In an alternate preferred embodiment, the cut-off value is determined using a Receiver Operator Curve, according to the method of Sackett et al.,  Clinical Epidemiology: A Basic Science for Clinical Medicine , Little Brown and Co., 1985, p. 106-7. Briefly, in this embodiment, the cut-off value may be determined from a plot of pairs of true positive rates (i.e., sensitivity) and false positive rates (100%-specificity) that correspond to each possible cut-off value for the diagnostic test result. The cut-off value on the plot that is the closest to the upper left-hand corner (i.e., the value that encloses the largest area) is the most accurate cut-off value, and a sample generating a signal that is higher than the cut-off value determined by this method may be considered positive. Alternatively, the cut-off value may be shifted to the left along the plot, to minimize the false positive rate, or to the right, to minimize the false negative rate. In general, a sample generating a signal that is higher than the cut-off value determined by this method is considered positive for lung cancer. 
     In a related embodiment, the assay is performed in a flow-through or strip test format, wherein the antibody is immobilized on a membrane, such as nitrocellulose. In the flow-through test, polypeptides within the sample bind to the immobilized antibody as the sample passes through the membrane. A second, labeled antibody then binds to the antibody-polypeptide complex as a solution containing the second antibody flows through the membrane. The detection of bound second antibody may then be performed as described above. In the strip test format, one end of the membrane to which antibody is bound is immersed in a solution containing the sample. The sample migrates along the membrane through a region containing second antibody and to the area of immobilized antibody. Concentration of second antibody at the area of immobilized antibody indicates the presence of lung cancer. Typically, the concentration of second antibody at that site generates a pattern, such as a line, that can be read visually. The absence of such a pattern indicates a negative result. In general, the amount of antibody immobilized on the membrane is selected to generate a visually discernible pattern when the biological sample contains a level of polypeptide that would be sufficient to generate a positive signal in the two-antibody sandwich assay, in the format discussed above. Preferably, the amount of antibody immobilized on the membrane ranges from about 25 ng to about 1 μg, and more preferably from about 50 ng to about 500 ng. Such tests can typically be performed with a very small amount of biological sample. 
     Of course, numerous other assay protocols exist that are suitable for use with the antigens or antibodies of the present invention. The above descriptions are intended to be exemplary only. 
     In another embodiment, the above polypeptides may be used as markers for the progression of lung cancer. In this embodiment, assays as described above for the diagnosis of lung cancer may be performed over time, and the change in the level of reactive polypeptide(s) evaluated. For example, the assays may be performed every 24-72 hours for a period of 6 months to 1 year, and thereafter performed as needed. In general, lung cancer is progressing in those patients in whom the level of polypeptide detected by the binding agent increases over time. In contrast, lung cancer is not progressing when the level of reactive polypeptide either remains constant or decreases with time. 
     Antibodies for use in the above methods may be prepared by any of a variety of techniques known to those of ordinary skill in the art. See, e.g., Harlow and Lane,  Antibodies: A Laboratory Manual , Cold Spring Harbor Laboratory, 1988. In one such technique, an immunogen comprising the antigenic polypeptide is initially injected into any of a wide variety of mammals (e.g., mice, rats, rabbits, sheep and goats). In this step, the polypeptides of this invention may serve as the immunogen without modification. Alternatively, particularly for relatively short polypeptides, a superior immune response may be elicited if the polypeptide is joined to a carrier protein, such as bovine serum albumin or keyhole limpet hemocyanin. The immunogen is injected into the animal host, preferably according to a predetermined schedule incorporating one or more booster immunizations, and the animals are bled periodically. Polyclonal antibodies specific for the polypeptide may then be purified from such antisera by, for example, affinity chromatography using the polypeptide coupled to a suitable solid support. 
     Monoclonal antibodies specific for the antigenic polypeptide of interest may be prepared, for example, using the technique of Kohler and Milstein,  Eur. J. Immunol . 6:511-519, 1976, and improvements thereto. Briefly, these methods involve the preparation of immortal cell lines capable of producing antibodies having the desired specificity (i.e., reactivity with the polypeptide of interest). Such cell lines may be produced, for example, from spleen cells obtained from an animal immunized as described above. The spleen cells are then immortalized by, for example, fusion with a myeloma cell fusion partner, preferably one that is syngeneic with the immunized animal. A variety of fusion techniques may be employed. For example, the spleen cells and myeloma cells may be combined with a nonionic detergent for a few minutes and then plated at low density on a selective medium that supports the growth of hybrid cells, but not myeloma cells. A preferred selection technique uses HAT (hypoxanthine, aminopterin, thymidine) selection. After a sufficient time, usually about 1 to 2 weeks, colonies of hybrids are observed. Single colonies are selected and tested for binding activity against the polypeptide. Hybridomas having high reactivity and specificity are preferred. 
     Monoclonal antibodies may be isolated from the supernatants of growing hybridoma colonies. In addition, various techniques may be employed to enhance the yield, such as injection of the hybridoma cell line into the peritoneal cavity of a suitable vertebrate host, such as a mouse. Monoclonal antibodies may then be harvested from the ascites fluid or the blood. Contaminants may be removed from the antibodies by conventional techniques, such as chromatography, gel filtration, precipitation, and extraction. The polypeptides of this invention may be used in the purification process in, for example, an affinity chromatography step. 
     Monoclonal antibodies of the present invention may also be used as therapeutic reagents, to diminish or eliminate lung tumors. The antibodies may be used on their own (for instance, to inhibit metastases) or coupled to one or more therapeutic agents. Suitable agents in this regard include radionuclides, differentiation inducers, drugs, toxins, and derivatives thereof. Preferred radionuclides include  90 Y,  123 I,  125 I,  131 I,  186 Re,  188 Re,  211 At, and  212 Bi. Preferred drugs include methotrexate, and pyrimidine and purine analogs. Preferred differentiation inducers include phorbol esters and butyric acid. Preferred toxins include ricin, abrin, diptheria toxin, cholera toxin, gelonin, Pseudomonas exotoxin, Shigella toxin, and pokeweed antiviral protein. 
     A therapeutic agent may be coupled (e.g., covalently bonded) to a suitable monoclonal antibody either directly or indirectly (e.g., via a linker group). A direct reaction between an agent and an antibody is possible when each possesses a substituent capable of reacting with the other. For example, a nucleophilic group, such as an amino or sulfhydryl group, on one may be capable of reacting with a carbonyl-containing group, such as an anhydride or an acid halide, or with an alkyl group containing a good leaving group (e.g., a halide) on the other. 
     Alternatively, it may be desirable to couple a therapeutic agent and an antibody via a linker group. A linker group can function as a spacer to distance an antibody from an agent in order to avoid interference with binding capabilities. A linker group can also serve to increase the chemical reactivity of a substituent on an agent or an antibody, and thus increase the coupling efficiency. An increase in chemical reactivity may also facilitate the use of agents, or functional groups on agents, which otherwise would not be possible. 
     It will be evident to those skilled in the art that a variety of bifunctional or polyfunctional reagents, both homo- and hetero-functional (such as those described in the catalog of the Pierce Chemical Co., Rockford, Ill.), may be employed as the linker group. Coupling may be effected, for example, through amino groups, carboxyl groups, sulfhydryl groups or oxidized carbohydrate residues. There are numerous references describing such methodology, e.g., U.S. Pat. No. 4,671,958, to Rodwell et al. 
     Where a therapeutic agent is more potent when free from the antibody portion of the immunoconjugates of the present invention, it may be desirable to use a linker group which is cleavable during or upon internalization into a cell. A number of different cleavable linker groups have been described. The mechanisms for the intracellular release of an agent from these linker groups include cleavage by reduction of a disulfide bond (e.g., U.S. Pat. No. 4,489,710, to Spitler), by irradiation of a photolabile bond (e.g., U.S. Pat. No. 4,625,014, to Senter et al.), by hydrolysis of derivatized amino acid side chains (e.g., U.S. Pat. No. 4,638,045, to Kohn et al.), by serum complement-mediated hydrolysis (e.g., U.S. Pat. No. 4,671,958, to Rodwell et al.), and acid-catalyzed hydrolysis (e.g., U.S. Pat. No. 4,569,789, to Blattler et al.). 
     It may be desirable to couple more than one agent to an antibody. In one embodiment, multiple molecules of an agent are coupled to one antibody molecule. In another embodiment, more than one type of agent may be coupled to one antibody. Regardless of the particular embodiment, immunoconjugates with more than one agent may be prepared in a variety of ways. For example, more than one agent may be coupled directly to an antibody molecule, or linkers which provide multiple sites for attachment can be used. Alternatively, a carrier can be used. 
     A carrier may bear the agents in a variety of ways, including covalent bonding either directly or via a linker group. Suitable carriers include proteins such as albumins (e.g., U.S. Pat. No. 4,507,234, to Kato et al.), peptides and polysaccharides such as aminodextran (e.g., U.S. Pat. No. 4,699,784, to Shih et al.). A carrier may also bear an agent by noncovalent bonding or by encapsulation, such as within a liposome vesicle (e.g., U.S. Pat. Nos. 4,429,008 and 4,873,088). Carriers specific for radionuclide agents include radiohalogenated small molecules and chelating compounds. For example, U.S. Pat. No. 4,735,792 discloses representative radiohalogenated small molecules and their synthesis. A radionuclide chelate may be formed from chelating compounds that include those containing nitrogen and sulfur atoms as the donor atoms for binding the metal, or metal oxide, radionuclide. For example, U.S. Pat. No. 4,673,562, to Davison et-al. discloses representative chelating compounds and their synthesis. 
     A variety of routes of administration for the antibodies and immunoconjugates may be used. Typically, administration will be intravenous, intramuscular, subcutaneous or in the bed of a resected tumor. It will be evident that the precise dose of the antibody/immunoconjugate will vary depending upon the antibody used, the antigen density on the tumor, and the rate of clearance of the antibody. 
     Diagnostic reagents of the present invention may also comprise polynucleotide sequences encoding one or more of the above polypeptides, or one or more portions thereof. For example, at least two oligonucleotide primers may be employed in a polymerase chain reaction (PCR) based assay to amplify lung tumor-specific cDNA derived from a biological sample, wherein at least one of the oligonucleotide primers is specific for a polynucleotide molecule encoding a lung tumor protein of the present invention. The presence of the amplified cDNA is then detected using techniques well known in the art, such as gel electrophoresis. Similarly, oligonucleotide probes specific for a polynucleotide molecule encoding a lung tumor protein of the present invention may be used in a hybridization assay to detect the presence of an inventive polypeptide in a biological sample. 
     As used herein, the term “oligonucleotide primer/probe specific for a polynucleotide molecule” means an oligonucleotide sequence that has at least about 60%, preferably at least about 75% and more preferably at least about 90%, identity to the polynucleotide molecule in question. Oligonucleotide primers and/or probes which may be usefully employed in the inventive diagnostic methods preferably have at least about 10-40 nucleotides. In a preferred embodiment, the oligonucleotide primers comprise at least about 10 contiguous nucleotides of a polynucleotide molecule comprising sequence selected from SEQ ID NO: 1-109, 111, 113 115-151, 153, 154, 157, 158, and 160. Preferably, oligonucleotide probes for use in the inventive diagnostic methods comprise at least about 15 contiguous oligonucleotides of a polynucleotide molecule comprising a sequence provided in SEQ ID NO: 1-109, 111, 113 115-151, 153, 154, 157, 158, and 160. Techniques for both PCR based assays and hybridization assays are well known in the art (see, for example, Mullis el al. Ibid; Ehrlich, Ibid). Primers or probes may thus be used to detect lung tumor-specific sequences in biological samples, including blood, semen, lung tissue and/or lung tumor tissue. 
    
    
     The following Examples are offered by way of illustration and not by way of limitation. 
     EXAMPLES 
     Example 1 
     Isolation and Characterization of cDNA Sequences Enconding Lung Tumor Polypeptides 
     This example illustrates the isolation of cDNA molecules encoding lung tumor-specific polypeptides from lung tumor cDNA libraries. 
     A. Isolation of cDNA Sequences from a Lung Squamous Cell Carcinoma Library 
     A human lung squamous cell carcinoma cDNA expression library was constructed from poly A +  RNA from a pool of two patient tissues using a Superscript Plasmid System for cDNA Synthesis and Plasmid Cloning kit (BRL Life Technologies, Gaithersburg, Md.) following the manufacturer&#39;s protocol. Specifically, lung carcinoma tissues were homogenized with polytron (Kinematica, Switzerland) and total RNA was extracted using Trizol reagent (BRL Life Technologies) as directed by the manufacturer. The poly A +  RNA was then purified using an oligo dT cellulose column as described in Sambrook et al.,  Molecular Cloning: A Laboratory Manual , Cold Spring Harbor Laboratories, Cold Spring Harbor, N.Y., 1989. First-strand cDNA was synthesized using the NotI/Oligo-dT18 primer. Double-stranded cDNA was synthesized, ligated with BstXI/EcoRI adaptors (Invitrogen, San Diego, Calif.) and digested with NotI. Following size fractionation with cDNA size fractionation columns (BRL Life Technologies), the cDNA was ligated into the BstXI/NotI site of pcDNA3.1 (Invitrogen) and transformed into ElectroMax  E. coli  DH10B cells (BRL Life Technologies) by electroporation. 
     Using the same procedure, a normal human lung cDNA expression library was prepared from a pool of four tissue specimens. The cDNA libraries were characterized by determining the number of independent colonies, the percentage of clones that carried insert, the average insert size and by sequence analysis. The lung squamous cell carcinoma library contained 2.7×10 6  independent colonies, with 100% of clones having an insert and the average insert size being 2100 base pairs. The normal lung cDNA library contained 1.4×10 6  independent colonies, with 90% of clones having inserts and the average insert size being 1800 base pairs. For both libraries, sequence analysis showed that the majority of clones had a full length cDNA sequence and were synthesized from mRNA. 
     cDNA library subtraction was performed using the above lung squamous cell carcinoma and normal lung cDNA libraries, as described by Hara et al. ( Blood , 84:189-199, 1994) with some modifications. Specifically, a lung squamous cell carcinoma-specific subtracted cDNA library was generated as follows. Normal tissue cDNA library (80 μg) was digested with BamHI and XhoI, followed by a filling-in reaction with DNA polymerase Klenow fragment. After phenol-chloroform extraction and ethanol precipitation, the DNA was dissolved in 133 μl of H 2 O, heat-denatured and mixed with 133 μl (133 μg) of Photoprobe biotin (Vector Laboratories, Burlingame, Calif.). As recommended by the manufacturer, the resulting mixture was irradiated with a 270 W sunlamp on ice for 20 minutes. Additional Photoprobe biotin (67 μl) was added and the biotinylation reaction was repeated. After extraction with butanol five times, the DNA was ethanol-precipitated and dissolved in 23 μl H 2 O to form the driver DNA. 
     To form the tracer DNA, 10 μg lung squamous cell carcinoma cDNA library was digested with NotI and SpeI, phenol chloroform extracted and passed through Chroma spin-400 columns (Clontech, Palo Alto, Calif.). Typically, 5 μg of cDNA was recovered after the sizing column. Following ethanol precipitation, the tracer DNA was dissolved in 5 μl H 2 O. Tracer DNA was mixed with 15 μl driver DNA and 20 μl of 2×hybridization buffer (1.5 M NaCl/10 mM EDTA/50 mM HEPES pH 7.5/0.2% sodium dodecyl sulfate), overlaid with mineral oil, and heat-denatured completely. The sample was immediately transferred into a 68° C. water bath and incubated for 20 hours (long hybridization [LH]). The reaction mixture was then subjected to a streptavidin treatment followed by phenol/chloroform extraction. This process was repeated three more times. Subtracted DNA was precipitated, dissolved in 12 μl H 2 O, mixed with 8 μl driver DNA and 20 μl of 2×hybridization buffer, and subjected to a hybridization at 68° C. for 2 hours (short hybridization [SH]). After removal of biotinylated double-stranded DNA, subtracted cDNA was ligated into NotI/Spel site of chloramphenicol resistant pBCSK +  (Stratagene, La Jolla, Calif.) and transformed into ElectroMax  E. coli  DH10B cells by electroporation to generate a lung squamous cell carcinoma specific subtracted cDNA library (herein after referred to as “lung subtraction I”). 
     A second lung squamous cell carcinoma specific subtracted cDNA library (referred to as “lung subtraction II”) was generated in a similar way to the lung subtraction library I, except that eight frequently recovered genes from lung subtraction I were included in the driver DNA, and 24,000 independent clones were recovered. 
     To analyze the subtracted cDNA libraries, plasmid DNA was prepared from 320 independent clones, randomly picked from the subtracted lung squamous cell carcinoma specific libraries. Representative cDNA clones were further characterized by DNA sequencing with a Perkin Elmer/Applied Biosystems Division Automated Sequencer Model 373A and/or Model 377 (Foster City, Calif.). The cDNA sequences for sixty isolated clones are provided in SEQ ID NO: 1-60. These sequences were compared to known sequences in the gene bank using the EMBL and GenBank databases (release 96). No significant homologies were found to the sequences provided in SEQ ID NO: 2, 3, 19, 38 and 46. The sequences of SEQ ID NO: 1, 6-8, 10-13, 15, 17, 18, 20-27, 29, 30, 32, 34-37, 39-45, 47-49, 51, 52, 54, 55 and 57-59 were found to show some homology to previously identified expressed sequence tags (ESTs). The sequences of SEQ ID NO: 9, 28, 31 and 33 were found to show some homology to previously identified non-human gene sequences and the sequences of SEQ ID NO: 4, 5, 14, 50, 53, 56 and 60 were found to show some homology to gene sequences previously identified in humans. 
     The subtraction procedure described above was repeated using the above lung squamous cell carcinoma cDNA library as the tracer DNA, and the above normal lung tissue cDNA library and a cDNA library from normal liver and heart (constructed from a pool of one sample of each tissue as described above), plus twenty other cDNA clones that were frequently recovered in lung subtractions I and II, as the driver DNA (lung subtraction III). The normal liver and heart cDNA library contained 1.76×10 6  independent colonies, with 100% of clones having inserts and the average insert size being 1600 base pairs. Ten additional clones were isolated (SEQ ID NO: 61-70). Comparison of these cDNA sequences with those in the gene bank as described above, revealed no significant homologies to the sequences provided in SEQ ID NO: 62 and 67. The sequences of SEQ ID NO: 61, 63-66, 68 and 69 were found to show some homology to previously isolated ESTs and the sequence provided in SEQ ID NO: 70 was found to show some homology to a previously identified rat gene. 
     B. Isolation of cDNA Sequences From a Lung Adenocarcinoma Library 
     A human lung adenocarcinoma cDNA expression library was constructed as described above. The library contained 3.2×10 6  independent colonies, with 100% of clones having an insert and the average insert size being 1500 base pairs. Library subtraction was performed as described above using the normal lung and normal liver and heart cDNA expression libraries described above as the driver DNA. Twenty-six hundred independent clones were recovered. 
     Initial cDNA sequence analysis from 100 independent clones revealed many ribosomal protein genes. The cDNA sequences for fifteen clones isolated in this subtraction are provided in SEQ ID NO: 71-86. Comparison of these sequences with those in the gene bank as described above revealed no significant homologies to the sequence provided in SEQ ID NO: 84. The sequences of SEQ ID NO: 71, 73, 74, 77, 78 and 80-82 were found to show some homology to previously isolated ESTs, and the sequences of SEQ ID NO: 72, 75, 76, 79, 83 and 85 were found to show some homology to previously identified human genes. 
     Example 2 
     Determination of Tissue Specificity of Lung Tumor Polypeptides 
     Using gene specific primers, mRNA expression levels for seven representative lung tumor polypeptides described in Example 1 were examined in a variety of normal and tumor tissues using RT-PCR. 
     Briefly, total RNA was extracted from a variety of normal and tumor tissues using Trizol reagent as described above. First strand synthesis was carried out using 2 μg of total RNA with SuperScript II reverse transcriptase (BRL Life Technologies) at 42° C. for one hour. The cDNA was then amplified by PCR with gene-specific primers. To ensure the semi-quantitative nature of the RT-PCR, β-actin was used as an internal control for each of the tissues examined. 1 μl of 1:30 dilution of cDNA was employed to enable the linear range amplification of the β-actin template and was sensitive enough to reflect the differences in the initial copy numbers. Using these conditions, the β-actin levels were determined for each reverse transcription reaction from each tissue. DNA contamination was minimized by DNase treatment and by assuring a negative PCR result when using first strand cDNA that was prepared without adding reverse transcriptase. 
     mRNA Expression levels were examined in five different types of tumor tissue (lung squamous cell carcinoma from 3 patients, lung adenocarcinoma, colon tumor from 2 patients, breast tumor and prostate tumor), and thirteen different normal tissues (lung from 4 donors, prostate, brain, kidney, liver, ovary, skeletal muscle, skin, small intestine, stomach, myocardium, retina and testes). Using a 10-fold amount of cDNA, the antigen LST-S1-90 (SEQ ID NO: 3) was found to be expressed at high levels in lung squamous cell carcinoma and in breast tumor, and at low to undetectable levels in the other tissues examined. 
     The antigen LST-S2-68 (SEQ ID NO: 15) appears to be specific to lung and breast tumor, however, expression was also detected in normal kidney. Antigens LST-S1-169 (SEQ ID NO: 6) and LST-S1-133 (SEQ ID NO: 5) appear to be very abundant in lung tissues (both normal and tumor), with the expression of these two genes being decreased in most of the normal tissues tested. Both LST-S1-169 and LST-S1-133 were also expressed in breast and colon tumors. Antigens LST-S1-6 (SEQ ID NO: 7) and LST-S2-12-5F (SEQ ID NO: 47) did not show tumor or tissue specific expression, with the expression of LST-S1-28 being rare and only detectable in a few tissues. The antigen LST-S3-7 (SEQ ID NO: 63) showed lung and breast tumor specific expression, with its message only being detected in normal testes when the PCR was performed for 30 cycles. Lower level expression was detected in some normal tissues when the cycle number was increased to 35. Antigen LST-S3-13 (SEQ ID NO: 66) was found to be expressed in 3 out of 4 lung tumors, one breast tumor and both colon tumor samples. Its expression in normal tissues was lower compared to tumors, and was only detected in 1 out of 4 normal lung tissues and in normal tissues from kidney, ovary and retina. Expression of antigens LST-S3-4 (SEQ ID NO: 62) and LST-S3-14 (SEQ ID NO: 67) was rare and did not show any tissue or tumor specificity. Consistent with Northern blot analyses, the RT-PCT results on antigen LAT-S1-A-10A (SEQ ID NO: 78) suggested that its expression is high in lung, colon, stomach and small intestine tissues, including lung and colon tumors, whereas its expression was low or undetectable in other tissues. 
     A total of 2002 cDNA fragments isolated in lung subtractions I, II and III, described above, were colony PCR amplified and their mRNA expression levels in lung tumor, normal lung, and various other normal and tumor tissues were determined using microarray technology (Synteni, Palo Alto, Calif.). Briefly, the PCR amplification products were dotted onto slides in an array format, with each product occupying a unique location in the array. mRNA was extracted from the tissue sample to be tested, reverse transcribed, and fluorescent-labeled cDNA probes were generated. The microarrays were probed with the labeled cDNA probes, the slides scanned and fluorescence intensity was measured. This intensity correlates with the hybridization intensity. Seventeen non-redundant cDNA clones showed over-expression in lung squamous tumors, with expression in normal tissues tested (lung, skin, lymph node, colon, liver, pancreas, breast, heart, bone marrow, large intestine, kidney, stomach, brain, small intestine, bladder and salivary gland) being either undetectable, or 10-fold less compared to lung squamous tumors. The determined partial cDNA sequences for the clone L513S are provided in SEQ ID NO: 87 and 88; those for L514S are provided in SEQ ID NO: 89 and 90; those for L516S in SEQ ID NO: 91 and 92; that for L517S in SEQ ID NO: 93; that for L519S in SEQ ID NO: 94; those for L520S in SEQ ID NO: 95 and 96; those for L521S in SEQ ID NO: 97 and 98; that for L522S in SEQ ID NO: 99; that for L523S in SEQ ID NO: 100; that for L524S in SEQ ID NO: 101; that for L525S in SEQ ID NO: 102; that for L526S in SEQ ID NO: 103; that for L527S in SEQ ID NO: 104; that for L528S in SEQ ID NO: 105; that for L529S in SEQ ID NO: 106; and those for L530S in SEQ ID NO: 107 and 108. Additionally, the full-length cDNA sequences for L503S and L514S (variants 1 and 2), are provided in SEQ ID NO: 151, 153, and 154, respectively, with the corresponding predicted amino acid sequence being provided in SEQ ID NO: 152, 155, and 156. Due to polymorphisms, the clone L531 S appears to have two forms. A first determined full-length cDNA sequence for L531S is provided in SEQ ID NO: 109, with the corresponding predicted amino acid sequence being provided in SEQ ID NO: 110. A second determined full-length cDNA sequence for L531S is provided in SEQ ID NO: 111, with the corresponding predicted amino acid sequence being provided in SEQ ID NO: 112. The sequence of SEQ ID NO: 111 is identical to that of SEQ ID NO: 109, except that it contains a 27 bp insertion. Similarly, L514S also has two alternatively spliced forms; the first variant cDNA is listed as SEQ ID NO: 153, with the corresponding amino acid sequence as SEQ ID NO: 155. The second variant form of L514S full-length cNDA is referred to as SEQ ID NO: 154, with its corresponding amino acid sequence as SEQ ID NO: 156. 
     Comparison of the sequences of L514S and L531 S (SEQ ID NO: 87 and 88, 89 and 90, and 109, respectively) with those in the gene bank, as described above, revealed no significant homologies to known sequences. The sequences of L513S, L516S, L517S, L519S, L520S and L530S (SEQ ID NO: 87 and 88, 91 and 92, 93, 94, 95 and 96, 107 and 108, respectively) were found to show some homology to previously identified ESTs. The sequences of L521S, L522S, L523S, L524S, L525S, L526S, L527S, L528S and L529S (SEQ ID NO: 97 and 98, 99, 99, 101, 102, 103, 104, 105, and 106, respectively) were found to represent known genes. The determined full-length cDNA sequences for L520S is provided in SEQ ID NO: 113, with the corresponding predicted amino acid sequence being provided in SEQ ID NO: 114. Subsequent microarray analysis has shown L520S to be overexpressed in breast tumors in addition to lung squamous tumors. 
     Example 3 
     Isolation and Characterization of Lung Tumor Polypeptides by PCR-based Subtraction 
     Eight hundred and fifty seven clones from a cDNA subtraction library, containing cDNA from a pool of two human lung squamous tumors subtracted against eight normal human tissue cDNAs including lung, PBMC, brain, heart, kidney, liver, pancreas, and skin, (Clontech, Palo Alto, Calif.) were derived and submitted to a first round of PCR amplification. This library was subjected to a second round of PCR amplification, following the manufacturer&#39;s protocol. The resulting cDNA fragments were subcloned into the vector P7- Adv vector (Clontech, Palo Alto, Calif.) and transformed into DH5α  E. coli  (Gibco, BRL). DNA was isolated from independent clones and sequenced using a Perkin Elmer/Applied Biosystems Division Automated Sequencer Model 373A. 
     One hundred and sixty two positive clones were sequenced. Comparison of the DNA sequences of these clones with those in the gene bank using the EMBL and GenBank databases, as described above, revealed no significant homologies to 13 of these clones, hereinafter referred to as Contig 13, 16, 17, 19, 22, 24, 29, 47, 49, 56-59. The determined cDNA sequences for these clones are provided in SEQ ID NO: 125, 127-129, 131-133, 142, 144, 148-150, and 157, respectively. Contigs 1, 3-5, 7-10, 12, 11, 15, 20, 31, 33, 38, 39, 41, 43, 44, 45, 48, 50, 53, 54 (SEQ ID NO: 115-124, 126, 130, 134-141, 143, 145-147, respectively) were found to show some degree of homology to previously identified DNA sequences. Contig 57 (SEQ ID NO: 149) was found to represent the clone L519S (SEQ ID NO: 94) disclosed in U.S. Pat. application Ser. No. 09/123,912, filed Jul. 27, 1998. To the best of the inventors&#39; knowledge, none of these sequences have been previously shown to be differentially over-expressed in lung tumors. mRNA expression levels for representative clones in lung tumor tissues, normal lung tissues (n=4), resting PBMC, salivary gland, heart, stomach, lymph nodes, skeletal muscle, soft palate, small intestine, large intestine, bronchial, bladder, tonsil, kidney, esophagus, bone marrow, colon, adrenal gland, pancreas, and skin, (all derived from human) were determined by RT-PCR as described above. Expression levels using microarray technology, as described above, were examined in one sample of each tissue type unless otherwise indicated. 
     Contig 3 (SEQ ID NO: 116) was found to be highly expressed in all head and neck squamous cell tumors tested (17/17), and expressed in the majority (8/12) of lung squamous tumors, (high expression in 7/12, moderate in 2/12, and low in 2/12), while showing negative expression for 2/4 normal lung tissues and low expression in the remaining two samples. Contig 3 showed high expression in skin and soft palate, and moderate expression levels in resting PBMC, large intestine, salivary gland, tonsil, pancreas, esophagus, and colon. Contig 11 (SEQ ID NO: 124) was found to be expressed in all head and neck squamous cell tumors tested (17/17): highly expressed in 14/17, and moderately expressed in 3/17. Additionally, expression in lung squamous tumors showed high expression in 3/12 and moderate in 4/12. Contig 11 was negative for 3/4 normal lung samples, with the remaining sample having only low expression. Contig 11 showed low to moderate reactivity to salivary gland, soft palate, bladder, tonsil, skin, esophagus, and large intestine. Contig 13 (SEQ ID NO: 125) was found to be expressed in all head and neck squamous cell tumors tested (17/17): highly expressed in 12/17, and moderately expressed in 5/17. Contig 13 was expressed in 7/12 lung squamous tumors, with high expression in 4/12 and moderate expression in three samples. Analysis of normal lung samples showed negative expression for 2/4 and low to moderate expression in the remaining two samples. Contig 13 did show low to moderate reactivity to resting PBMC, salivary gland, bladder, pancreas, tonsil, skin, esophagus, and large intestine, as well as high expression in soft palate. Contig 16 (SEQ ID NO: 127) was found to be moderately expressed in some head and neck squamous cell tumors (6/17) and one lung squamous tumor; while showing no expression in any normal lung samples tested. Contig 16 did show low to moderate reactivity to resting PBMC, large intestine, skin, salivary gland, and soft palate. Contig 17 (SEQ ID NO: 128) was shown to be expressed in all head and neck squamous cell tumors tested (17/17): highly expressed in 5/17, and moderately expressed in 12/17. Expression levels in lung squamous tumors showed one tumor sample with high expression and 3/12 with moderate levels. Contig 17 was negative for 2/4 normal lung samples, with the remaining samples having only low expression. Additionally, moderate expression was found in esophagus and soft palate, and low expression in resting PBMC, large intestine, skin, salivary gland, bladder, and pancreas. Contig 19 (SEQ ID NO: 129) was found to be expressed in most head and neck squamous cell tumors tested (11/17): with two samples having high levels, 6/17 showing moderate expression, and low expression being found in 3/17. Testing in lung squamous tumors revealed only moderate expression in 3/12 samples. Expression levels in 2/4 of normal lung samples were negative, the two other samples having only low expression. Contig 19 did show moderate expression in large intestine as well as low expression levels in esophagus, resting PBMC, salivary gland, bladder, soft palate, and pancreas. 
     Contig 22, (SEQ ID NO: 131) was shown to be expressed in most head and neck squamous cell tumors tested (13/17) with high expression in four of these samples, moderate expression in 6/17, and low expression in 3/17. Expression levels in lung squamous tumors were found to be moderate to high for 3/12 tissues tested, with negative expression in two normal lung samples and low expression in two other samples (n=4). Contig 22 did show low expression in resting PBMC, bladder, large intestine, skin, salivary gland, soft palate, and pancreas. Similarly, Contig 24 (SEQ ID NO: 132) was found to be expressed in most head and neck squamous cell tumors tested (13/17) with high expression in three of these samples, moderate expression in 6/17, and low expression in 4/17. Expression levels in lung squamous tumors were found to be moderate to high for 3/12 tissues tested, with negative expression for three normal lung samples and low expression in one sample (n=4). Contig 24 did show low expression in resting PBMC, large intestine, salivary gland, soft palate, and pancreas. Contig 29 (SEQ ID NO: 133) was expressed in nearly all head and neck squamous cell tumors tested (16/17): highly expressed in 4/17, moderately expressed in 11/17, with low expression in one sample. Also, it was moderately expressed in 3/12 lung squamous tumors, while being negative for 2/4 normal lung samples. Contig 29 showed moderate expression in large intestine, skin, salivary gland, pancreas, and soft palate, and low expression in resting PBMC, bladder, tonsil, and heart. Contig 47 (SEQ ID NO: 142) was expressed in most head and neck squamous cell tumors tested (12/17): moderate expression in 10/17, and low expression in two samples. In lung squamous tumors, it was highly expressed in one sample and moderately expressed in two others (n=13). Contig 47 was negative for 2/4 normal lung samples, with the remaining two samples having moderate expression. Also, Contig 47 showed moderate expression in large intestine, and pancreas, and low expression in skin, salivary gland, soft palate, stomach, bladder, resting PBMC, and tonsil. 
     Contig 48 (SEQ ID NO: 143) was expressed in all head and neck squamous cell tumors tested (17/17): highly expressed in 8/17 and moderately expressed in 7/17, with low expression in two samples. Expression levels in lung squamous tumors were high to moderate in three samples (n=13). Contig 48 was negative for one out of four normal lung samples, the remaining showing low or moderate expression. Contig 48 showed moderate expression in soft palate, large intestine, pancreas, and bladder, and low expression in esophagus, salivary gland, resting PBMC, and heart. Contig 49 (SEQ ID NO: 144) was expressed at low to moderate levels in 6/17 head and neck squamous cell tumors tested. Expression levels in lung squamous tumors were moderate in three samples (n=13). Contig 49 was negative for 2/4 normal lung samples, the remaining samples showing low expression. Moderate expression levels in skin, salivary gland, large intestine, pancreas, bladder and resting PBMC were shown, as well as low expression in soft palate, lymph nodes, and tonsil. Contig 56 (SEQ ID NO: 148) was expressed in low to moderate levels in 3/17 head and neck squamous cell tumors tested, and in lung squamous tumors, showing low to moderate levels in three out of thirteen samples. Notably, low expression levels were detected in one adenocarcinoma lung tumor sample (n=2). Contig 56 was negative for 3/4 normal lung samples, and showed moderate expression levels in only large intestine, and low expression in salivary gland, soft palate, pancreas, bladder, and resting PBMC. Contig 58, also known as L769P, (SEQ ID NO: 150) was expressed at moderate levels in 11/17 head and neck squamous cell tumors tested and low expression in one additional sample. Expression in lung squamous tumors showed low to moderate levels in three out of thirteen samples. Contig 58 was negative for 3/4 normal lung samples, with one sample having low expression. Moderate expression levels in skin, large intestine, and resting PBMC were demonstrated, as well as low expression in salivary gland, soft palate, pancreas, and bladder. Contig 59 (SEQ ID NO: 157) was expressed in some head, neck, and lung squamous tumors. Low level expression of Contig 59 was also detected in salivary gland and large intestine. 
     Additionally, the full-length cDNA sequence for Contigs 22, referred to as L763P, is provided in SEQ ID NO: 158, with the corresponding predicted amino acid sequence being provided in SEQ ID NO: 159. Also, the full-length cDNA sequence incorporating Contigs 17, 19, and 24, referred to as L762P, is provided in SEQ ID NO: 160, with the corresponding predicted amino acid sequence being provided in SEQ ID NO: 161. 
     Subsequent microarray analysis has shown Contig 58, also referred to as L769S (SEQ ID NO: 150), to be overexpressed in breast tumors in addition to lung squamous tumors. 
     Example 4 
     SYNTHESIS OF POLYPEPTIDES 
     Polypeptides may be synthesized on a Perkin Elmer/Applied Biosystems Division 430A peptide synthesizer using FMOC chemistry with HPTU (O-Benzotriazole-N,N,N′,N′-tetramethyluronium hexafluorophosphate) activation. A Gly-Cys-Gly sequence may be attached to the amino terminus of the peptide to provide a method of conjugation, binding to an immobilized surface, or labeling of the peptide. Cleavage of the peptides from the solid support may be carried out using the following cleavage mixture: trifluoroacetic acid:ethanedithiol:thioanisole:water:phenol (40:1:2:2:3). After cleaving for 2 hours, the peptides may be precipitated in cold methyl-t-butyl-ether. The peptide pellets may then be dissolved in water containing 0.1% trifluoroacetic acid (TFA) and lyophilized prior to purification by C18 reverse phase HPLC. A gradient of 0%-60% acetonitrile (containing 0.1% TFA) in water (containing 0.1% TFA) may be used to elute the peptides. Following lyophilization of the pure fractions, the peptides may be characterized using electrospray or other types of mass spectrometry and by amino acid analysis. 
     From the foregoing, it will be appreciated that, although specific embodiments of the invention have been described herein for the purposes of illustration, various modifications may be made without deviating from the spirit and scope of the invention. 
     
       
         
           
               
            
               
                   
               
               
                                                SEQUENCE LISTING 
               
               
                   
               
               
                   
               
               
                 &lt;160&gt; NUMBER OF SEQ ID NOS: 161 
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 1 
               
               
                 &lt;211&gt; LENGTH: 315 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (236) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (241) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 1 
               
               
                   
               
               
                 gcagagacag actggtggtt gaacctggag gtgccaaaaa agccagctgc gggcccagga     60 
               
               
                   
               
               
                 cagctgccgt gagactcccg atgtcacagg cagtctgtgt ggttacagcg cccctcagtg    120 
               
               
                   
               
               
                 ttcatctcca gcagagacaa cggaggaggc tcccaccagg acggttctca ttatttatat    180 
               
               
                   
               
               
                 gttaatatgt ttgtaaactc atgtacagtt ttttttgggg gggaagcaat gggaanggta    240 
               
               
                   
               
               
                 naaattacaa atagaatcat ttgctgtaat ccttaaatgg caaacggtca ggccacgtga    300 
               
               
                   
               
               
                 aaaaaaaaaa aaaaa                                                     315 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 2 
               
               
                 &lt;211&gt; LENGTH: 380 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 2 
               
               
                   
               
               
                 atttaggctt aagattttgt ttacccttgt tactaaggag caaattagta ttaaagtata     60 
               
               
                   
               
               
                 atatatataa acaaatacaa aaagttttga gtggttcagc ttttttattt tttttaatgg    120 
               
               
                   
               
               
                 cataactttt aacaacactg ctctgtaatg ggttgaactg tggtactcag actgagataa    180 
               
               
                   
               
               
                 ctgaaatgag tggatgtata gtgttattgc ataattatcc cactatgaag caaagggact    240 
               
               
                   
               
               
                 ggataaattc ccagtctaga ttattagcct ttgttaacca tcaagcacct agaagaagaa    300 
               
               
                   
               
               
                 ttattggaaa ttttgtcctc tgtaactggc actttggggt gtgacttatc ttttgccttt    360 
               
               
                   
               
               
                 gtaaaaaaaa aaaaaaaaaa                                                380 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 3 
               
               
                 &lt;211&gt; LENGTH: 346 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (316) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (317) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (318) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (322) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (323) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (326) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (329) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (330) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (331) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (336) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (337) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (339) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (340) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (342) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (343) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 3 
               
               
                   
               
               
                 ttgtaagtat acaattttag aaaggattaa atgttattga tcattttact gaatactgca     60 
               
               
                   
               
               
                 catcctcacc atacaccatc cactttccaa taacatttaa tcctttctaa aattgtaagt    120 
               
               
                   
               
               
                 atacaattgt actttctttg gattttcata acaaatatac catagactgt taattttatt    180 
               
               
                   
               
               
                 gaagtttcct taatggaatg agtcattttt gtcttgtgct tttgaggtta cctttgcttt    240 
               
               
                   
               
               
                 gacttccaac aatttgatca tatagtgttg agctgtggaa atctttaagt ttattctata    300 
               
               
                   
               
               
                 gcaataattt ctattnnnag annccnggnn naaaannann annaaa                   346 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 4 
               
               
                 &lt;211&gt; LENGTH: 372 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (296) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (306) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (332) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 4 
               
               
                   
               
               
                 actagtctca ttactccaga attatgctct tgtacctgtg tggctgggtt tcttagtcgt     60 
               
               
                   
               
               
                 tggtttggtt tggttttttg aactggtatg tagggtggtt cacagttcta atgtaagcac    120 
               
               
                   
               
               
                 tctcttctcc aagttgtgct ttgtggggac aatcattctt tgaacattag agaggaaggc    180 
               
               
                   
               
               
                 agttcaagct gttgaaaaga ctattgctta tttttgtttt taaagaccta cttgacgtca    240 
               
               
                   
               
               
                 tgtggacagt gcacgtgcct tacgctacat cttgttttct aggaagaagg ggatgcnggg    300 
               
               
                   
               
               
                 aaggantggg tgctttgtga tggataaaac gnctaaataa cacaccttta cattttgaaa    360 
               
               
                   
               
               
                 aaaacaaaac aa                                                        372 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 5 
               
               
                 &lt;211&gt; LENGTH: 698 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (8) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (345) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (422) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (430) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (433) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (436) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (438) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (472) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (481) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (486) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (515) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (521) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (526) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (549) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (553) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (556) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (557) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (559) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (568) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (593) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (597) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (605) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (611) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (613) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (616) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (618) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (620) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (628) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (630) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (632) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (634) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (635) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (639) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (643) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (647) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (648) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (649) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (652) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (654) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (658) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (664) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (690) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 5 
               
               
                   
               
               
                 actagtanga tagaaacact gtgtcccgag agtaaggaga gaagctacta ttgattagag     60 
               
               
                   
               
               
                 cctaacccag gttaactgca agaagaggcg ggatactttc agctttccat gtaactgtat    120 
               
               
                   
               
               
                 gcataaagcc aatgtagtcc agtttctaag atcatgttcc aagctaactg aatcccactt    180 
               
               
                   
               
               
                 caatacacac tcatgaactc ctgatggaac aataacaggc ccaagcctgt ggtatgatgt    240 
               
               
                   
               
               
                 gcacacttgc tagactcaga aaaaatacta ctctcataaa tgggtgggag tattttgggt    300 
               
               
                   
               
               
                 gacaacctac tttgcttggc tgagtgaagg aatgatattc atatnttcat ttattccatg    360 
               
               
                   
               
               
                 gacatttagt tagtgctttt tatataccag gcatgatgct gagtgacact cttgtgtata    420 
               
               
                   
               
               
                 tntccaaatn ttngtncngt cgctgcacat atctgaaatc ctatattaag antttcccaa    480 
               
               
                   
               
               
                 natgangtcc ctggtttttc cacgccactt gatcngtcaa ngatctcacc tctgtntgtc    540 
               
               
                   
               
               
                 ctaaaaccnt ctnctnnang gttagacngg acctctcttc tcccttcccg aanaatnaag    600 
               
               
                   
               
               
                 tgtgngaaga nanccncncn cccccctncn tncnncctng ccngctnnnc cncntgtngg    660 
               
               
                   
               
               
                 gggngccgcc cccgcggggg gacccccccn ttttcccc                            698 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 6 
               
               
                 &lt;211&gt; LENGTH: 740 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (82) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (406) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (426) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (434) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (462) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (536) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (551) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (558) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (563) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (567) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (582) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (584) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (592) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (638) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (651) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (660) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (664) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (673) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (675) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (697) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (706) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (711) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (715) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (716) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (717) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (723) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (724) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (725) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (733) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 6 
               
               
                   
               
               
                 actagtcaaa aatgctaaaa taatttggga gaaaatattt tttaagtagt gttatagttt     60 
               
               
                   
               
               
                 catgtttatc ttttattatg tnttgtgaag ttgtgtcttt tcactaatta cctatactat    120 
               
               
                   
               
               
                 gccaatattt ccttatatct atccataaca tttatactac atttgtaaga gaatatgcac    180 
               
               
                   
               
               
                 gtgaaactta acactttata aggtaaaaat gaggtttcca agatttaata atctgatcaa    240 
               
               
                   
               
               
                 gttcttgtta tttccaaata gaatggactt ggtctgttaa ggggctaagg gagaagaaga    300 
               
               
                   
               
               
                 agataaggtt aaaagttgtt aatgaccaaa cattctaaaa gaaatgcaaa aaaaaattta    360 
               
               
                   
               
               
                 ttttcaagcc ttcgaactat ttaaggaaag caaaatcatt tcctanatgc atatcatttg    420 
               
               
                   
               
               
                 tgagantttc tcantaatat cctgaatcat tcatttcagc tnaggcttca tgttgactcg    480 
               
               
                   
               
               
                 atatgtcatc tagggaaagt ctatttcatg gtccaaacct gttgccatag ttggtnaggc    540 
               
               
                   
               
               
                 tttcctttaa ntgtgaanta ttnacangaa attttctctt tnanagttct tnatagggtt    600 
               
               
                   
               
               
                 aggggtgtgg gaaaagcttc taacaatctg tagtgttncg tgttatctgt ncagaaccan    660 
               
               
                   
               
               
                 aatnacggat cgnangaagg actgggtcta tttacangaa cgaatnatct ngttnnntgt    720 
               
               
                   
               
               
                 gtnnncaact ccngggagcc                                                740 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 7 
               
               
                 &lt;211&gt; LENGTH: 670 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (265) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (268) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (457) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (470) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (485) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (546) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (553) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (566) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (590) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (596) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (613) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (624) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (639) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (653) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (659) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (661) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 7 
               
               
                   
               
               
                 gctggggagc tcggcatggc ggtccccgct gcagccatgg ggccctcggc gttgggccag     60 
               
               
                   
               
               
                 agcggccccg gctcgatggc cccgtggtgc tcagtgagca gcggcccgtc gcgctacgtg    120 
               
               
                   
               
               
                 cttgggatgc aggagctgtt ccggggccac agcaagaccg cgagttcctg gcgcacagcg    180 
               
               
                   
               
               
                 ccaaggtgca ctcggtggcc tggagttgcg acgggcgtcg cctacctcgg ggtcttcgac    240 
               
               
                   
               
               
                 aagacgccac gtcttcttgc tgganaanga ccgttggtca aagaaaacaa ttatcgggga    300 
               
               
                   
               
               
                 catggggata gtgtggacca ctttgttggc atccaagtaa tcctgaccta tttgttacgg    360 
               
               
                   
               
               
                 cgtctggaga taaaaccatt cgcatctggg atgtgaggac tacaaaatgc attgccactg    420 
               
               
                   
               
               
                 tgaacactaa aggggagaac attaatatct gctggantcc tgatgggcan accattgctg    480 
               
               
                   
               
               
                 tagcnacaag gatgatgtgg tgactttatt gatgccaaga aaccccgttc caaagcaaaa    540 
               
               
                   
               
               
                 aaacanttcc aanttcgaag tcaccnaaat ctcctggaac aatgaacatn aatatnttct    600 
               
               
                   
               
               
                 tcctgacaat ggnccttggg tgtntcacat cctcagctnc cccaaaactg aancctgtnc    660 
               
               
                   
               
               
                 natccacccc                                                           670 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 8 
               
               
                 &lt;211&gt; LENGTH: 689 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (253) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (335) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (410) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (428) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (448) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (458) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (466) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (479) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (480) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (482) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (483) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (485) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (488) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (491) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (492) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (495) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (499) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (500) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (502) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (503) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (512) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (516) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (524) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (525) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (526) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (527) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (530) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (540) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (546) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (550) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (581) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (593) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (594) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (601) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (606) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (609) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (610) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (620) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (621) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (622) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (628) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (641) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (646) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (656) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (673) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 8 
               
               
                   
               
               
                 actagtatct aggaatgaac agtaaaagag gagcagttgg ctacttgatt acaacagagt     60 
               
               
                   
               
               
                 aaatgaagta ctggatttgg gaaaacctgg ttttattaga acatatggaa tgaaagccta    120 
               
               
                   
               
               
                 cacctagcat tgcctactta gccccctgaa ttaacagagc ccaattgaga caaacccctg    180 
               
               
                   
               
               
                 gcaacaggaa attcaaggga gaaaaagtaa gcaacttggg ctaggatgag ctgactccct    240 
               
               
                   
               
               
                 tagagcaaag ganagacagc ccccattacc aaataccatt tttgcctggg gcttgtgcag    300 
               
               
                   
               
               
                 ctggcagtgt tcctgcccca gcatggcacc ttatngtttt gatagcaact tcgttgaatt    360 
               
               
                   
               
               
                 ttcaccaact tattacttga aattataata tagcctgtcc gtttgctgtn tccaggctgt    420 
               
               
                   
               
               
                 gatatatntt cctagtggtt tgactttnaa aataaatnag gtttantttt ctccccccnn    480 
               
               
                   
               
               
                 cnntnctncc nntcnctcnn cnntcccccc cnctcngtcc tccnnnnttn gggggggccn    540 
               
               
                   
               
               
                 cccccncggn ggacccccct ttggtccctt agtggaggtt natggcccct ggnnttatcc    600 
               
               
                   
               
               
                 nggccntann tttccccgtn nnaaatgntt ccccctccca ntcccnccac ctcaanccgg    660 
               
               
                   
               
               
                 aagcctaagt ttntaccctg ggggtcccc                                      689 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 9 
               
               
                 &lt;211&gt; LENGTH: 674 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (602) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (632) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (639) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (668) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 9 
               
               
                   
               
               
                 gtccactctc ctttgagtgt actgtcttac tgtgcactct gtttttcaac tttctagata     60 
               
               
                   
               
               
                 taaaaaatgc ttgttctata gtggagtaag agctcacaca cccaaggcag caagataact    120 
               
               
                   
               
               
                 gaaaaaagcg aggctttttt gccaccttgg taaaggccag ttcactgcta tagaactgct    180 
               
               
                   
               
               
                 ataagcctga agggaagtag ctatgagact ttccattttt cttagttctc ccaataggct    240 
               
               
                   
               
               
                 ccttcatgga aaaaggcttc ctgtaataat tttcacctaa tgaattagca gtgtgattat    300 
               
               
                   
               
               
                 ttctgaaata agagacaaat tgggccgcag agtcttcctg tgatttaaaa taaacaaccc    360 
               
               
                   
               
               
                 aaagttttgt ttggtcttca ccaaaggaca tactctaggg ggtatgttgt tgaagacatt    420 
               
               
                   
               
               
                 caaaaacatt agctgttctg tctttcaatt tcaagttatt ttggagactg cctccatgtg    480 
               
               
                   
               
               
                 agttaattac tttgctctgg aactagcatt attgtcatta tcatcacatt ctgtcatcat    540 
               
               
                   
               
               
                 catctgaata atattgtgga tttccccctc tgcttgcatc ttcttttgac tcctctggga    600 
               
               
                   
               
               
                 anaaatgtca aaaaaaaagg tcgatctact cngcaaggnc catctaatca ctgcgctgga    660 
               
               
                   
               
               
                 aggacccnct gccc                                                      674 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 10 
               
               
                 &lt;211&gt; LENGTH: 346 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (320) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (321) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (322) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (325) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (326) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (328) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (329) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (330) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (332) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (333) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (334) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (335) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (342) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 10 
               
               
                   
               
               
                 actagtctgc tgatagaaag cactatacat cctattgttt ctttctttcc aaaatcagcc     60 
               
               
                   
               
               
                 ttctgtctgt aacaaaaatg tactttatag agatggagga aaaggtctaa tactacatag    120 
               
               
                   
               
               
                 ccttaagtgt ttctgtcatt gttcaagtgt attttctgta acagaaacat atttggaatg    180 
               
               
                   
               
               
                 tttttctttt ccccttataa attgtaattc ctgaaatact gctgctttaa aaagtcccac    240 
               
               
                   
               
               
                 tgtcagatta tattatctaa caattgaata ttgtaaatat acttgtctta cctctcaata    300 
               
               
                   
               
               
                 aaagggtact tttctattan nnagnngnnn gnnnnataaa anaaaa                   346 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 11 
               
               
                 &lt;211&gt; LENGTH: 602 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 11 
               
               
                   
               
               
                 actagtaaaa agcagcattg ccaaataatc cctaattttc cactaaaaat ataatgaaat     60 
               
               
                   
               
               
                 gatgttaagc tttttgaaaa gtttaggtta aacctactgt tgttagatta atgtatttgt    120 
               
               
                   
               
               
                 tgcttccctt tatctggaat gtggcattag cttttttatt ttaaccctct ttaattctta    180 
               
               
                   
               
               
                 ttcaattcca tgacttaagg ttggagagct aaacactggg atttttggat aacagactga    240 
               
               
                   
               
               
                 cagttttgca taattataat cggcattgta catagaaagg atatggctac cttttgttaa    300 
               
               
                   
               
               
                 atctgcactt tctaaatatc aaaaaaggga aatgaagtta taaatcaatt tttgtataat    360 
               
               
                   
               
               
                 ctgtttgaaa catgagtttt atttgcttaa tattagggct ttgccccttt tctgtaagtc    420 
               
               
                   
               
               
                 tcttgggatc ctgtgtagaa ctgttctcat taaacaccaa acagttaagt ccattctctg    480 
               
               
                   
               
               
                 gtactagcta caaattcggt ttcatattct acttaacaat ttaaataaac tgaaatattt    540 
               
               
                   
               
               
                 ctagatggtc tacttctgtt catataaaaa caaaacttga tttccaaaaa aaaaaaaaaa    600 
               
               
                   
               
               
                 aa                                                                   602 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 12 
               
               
                 &lt;211&gt; LENGTH: 685 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (170) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (279) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (318) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (321) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (322) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (422) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (450) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (453) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (459) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (467) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (468) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (470) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (473) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (475) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (482) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (485) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (486) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (491) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (498) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (503) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (506) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (509) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (522) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (526) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (527) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (528) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (538) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (542) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (544) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (551) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (567) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (568) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (569) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (574) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (576) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (582) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (587) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (588) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (589) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (590) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (592) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (593) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (598) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (599) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (603) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (605) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (608) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (633) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (634) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (635) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (644) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (646) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (648) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (651) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (655) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (660) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (662) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (663) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (672) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (674) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (675) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (682) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (683) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 12 
               
               
                   
               
               
                 actagtcctg tgaaagtaca actgaaggca gaaagtgtta ggattttgca tctaatgttc     60 
               
               
                   
               
               
                 attatcatgg tattgatgga cctaagaaaa taaaaattag actaagcccc caaataagct    120 
               
               
                   
               
               
                 gcatgcattt gtaacatgat tagtagattt gaatatatag atgtagtatn ttgggtatct    180 
               
               
                   
               
               
                 aggtgtttta tcattatgta aaggaattaa agtaaaggac tttgtagttg tttttattaa    240 
               
               
                   
               
               
                 atatgcatat agtagagtgc aaaaatatag caaaaatana aactaaaggt agaaaagcat    300 
               
               
                   
               
               
                 tttagatatg ccttaatnta nnaactgtgc caggtggccc tcggaataga tgccaggcag    360 
               
               
                   
               
               
                 agaccagtgc ctgggtggtg cctccccttg tctgcccccc tgaagaactt ccctcacgtg    420 
               
               
                   
               
               
                 angtagtgcc ctcgtaggtg tcacgtggan tantggganc aggccgnncn gtnanaagaa    480 
               
               
                   
               
               
                 ancanngtga nagtttcncc gtngangcng aactgtccct gngccnnnac gctcccanaa    540 
               
               
                   
               
               
                 cntntccaat ngacaatcga gtttccnnnc tccngnaacc tngccgnnnn cnngcccnnc    600 
               
               
                   
               
               
                 cantntgnta accccgcgcc cggatcgctc tcnnntcgtt ctcncncnaa ngggntttcn    660 
               
               
                   
               
               
                 cnnccgccgt cncnnccccg cnncc                                          685 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 13 
               
               
                 &lt;211&gt; LENGTH: 694 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (503) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (546) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (599) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (611) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (636) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (641) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (643) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (645) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (656) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (658) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (662) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (676) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (679) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (687) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 13 
               
               
                   
               
               
                 cactagtcac tcattagcgt tttcaatagg gctcttaagt ccagtagatt acgggtagtc     60 
               
               
                   
               
               
                 agttgacgaa gatctggttt acaagaacta attaaatgtt tcattgcatt tttgtaagaa    120 
               
               
                   
               
               
                 cagaataatt ttataaaatg tttgtagttt ataattgccg aaaataattt aaagacactt    180 
               
               
                   
               
               
                 tttctctgtg tgtgcaaatg tgtgtttgtg atccattttt tttttttttt taggacacct    240 
               
               
                   
               
               
                 gtttactagc tagctttaca atatgccaaa aaaggatttc tccctgaccc catccgtggt    300 
               
               
                   
               
               
                 tcaccctctt ttccccccat gctttttgcc ctagtttata acaaaggaat gatgatgatt    360 
               
               
                   
               
               
                 taaaaagtag ttctgtatct tcagtatctt ggtcttccag aaccctctgg ttgggaaggg    420 
               
               
                   
               
               
                 gatcattttt tactggtcat ttccctttgg agtgtactac tttaacagat ggaaagaact    480 
               
               
                   
               
               
                 cattggccat ggaaacagcc gangtgttgg gagccagcag tgcatggcac cgtccggcat    540 
               
               
                   
               
               
                 ctggcntgat tggtctggct gccgtcattg tcagcacagt gccatgggac atggggaana    600 
               
               
                   
               
               
                 ctgactgcac ngccaatggt tttcatgaag aatacngcat ncncngtgat cacgtnancc    660 
               
               
                   
               
               
                 angacgctat gggggncana gggccanttg cttc                                694 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 14 
               
               
                 &lt;211&gt; LENGTH: 679 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (29) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (68) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (83) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (87) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (94) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (104) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (117) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (142) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (145) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (151) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (187) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (201) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (211) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (226) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (229) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (239) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (241) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (245) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (252) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (255) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (259) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (303) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (309) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (359) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (387) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (400) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (441) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (446) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (461) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (492) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (504) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (505) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (512) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (525) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (527) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (533) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (574) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (592) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (609) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (610) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (618) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (620) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (626) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (627) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (633) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (639) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (645) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (654) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 14 
               
               
                   
               
               
                 cagccgcctg catctgtatc cagcgccang tcccgccagt cccagctgcg cgcgcccccc     60 
               
               
                   
               
               
                 agtcccgnac ccgttcggcc cangctnagt tagncctcac catnccggtc aaaggangca    120 
               
               
                   
               
               
                 ccaagtgcat caaatacctg cngtncggat ntaaattcat cttctggctt gccgggattg    180 
               
               
                   
               
               
                 ctgtccntgc cattggacta nggctccgat ncgactctca gaccanganc atcttcganc    240 
               
               
                   
               
               
                 naganactaa tnatnattnt tccagcttct acacaggagt ctatattctg atcggatccg    300 
               
               
                   
               
               
                 gcnccctcnt gatgctggtg ggcttcctga gctgctgcgg ggctgtgcaa gagtcccant    360 
               
               
                   
               
               
                 gcatgctggg actgttcttc ggcttcntct tggtgatatn cgccattgaa atacctgcgg    420 
               
               
                   
               
               
                 ccatctgggg atattccact ncgatnatgt gattaaggaa ntccacggag ttttacaagg    480 
               
               
                   
               
               
                 acacgtacaa cnacctgaaa accnnggatg anccccaccg ggaancnctg aangccatcc    540 
               
               
                   
               
               
                 actatgcgtt gaactgcaat ggtttggctg gggnccttga acaatttaat cncatacatc    600 
               
               
                   
               
               
                 tggccccann aaaggacntn ctcganncct tcnccgtgna attcngttct gatnccatca    660 
               
               
                   
               
               
                 cagaagtctc gaacaatcc                                                 679 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 15 
               
               
                 &lt;211&gt; LENGTH: 695 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (105) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (172) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (176) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (179) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (189) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (203) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (212) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (219) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (221) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (229) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (231) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (238) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (242) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (261) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (266) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (270) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (278) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (285) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (286) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (298) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (311) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (324) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (337) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (350) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (363) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (384) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (391) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (395) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (405) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (411) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (424) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (427) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (443) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (448) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (453) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (455) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (458) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (463) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (467) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (470) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (479) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (481) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (484) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (493) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (499) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (505) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (518) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (520) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (523) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (531) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (540) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (584) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (595) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (597) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (609) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (611) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (626) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (628) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (651) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (652) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (657) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (661) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (665) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (669) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (672) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (681) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (683) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (691) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (693) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 15 
               
               
                   
               
               
                 actagtggat aaaggccagg gatgctgctc aacctcctac catgtacagg gacgtctccc     60 
               
               
                   
               
               
                 cattacaact acccaatccg aagtgtcaac tgtgtcagga ctaanaaacc ctggttttga    120 
               
               
                   
               
               
                 ttaaaaaagg gcctgaaaaa aggggagcca caaatctgtc tgcttcctca cnttantcnt    180 
               
               
                   
               
               
                 tggcaaatna gcattctgtc tcnttggctg cngcctcanc ncaaaaaanc ngaactcnat    240 
               
               
                   
               
               
                 cnggcccagg aatacatctc ncaatnaacn aaattganca aggcnntggg aaatgccnga    300 
               
               
                   
               
               
                 tgggattatc ntccgcttgt tgancttcta agtttcnttc ccttcattcn accctgccag    360 
               
               
                   
               
               
                 ccnagttctg ttagaaaaat gccngaattc naacnccggt tttcntactc ngaatttaga    420 
               
               
                   
               
               
                 tctncanaaa cttcctggcc acnattcnaa ttnanggnca cgnacanatn ccttccatna    480 
               
               
                   
               
               
                 ancncacccc acntttgana gccangacaa tgactgcntn aantgaaggc ntgaaggaan    540 
               
               
                   
               
               
                 aactttgaaa ggaaaaaaaa ctttgtttcc ggccccttcc aacncttctg tgttnancac    600 
               
               
                   
               
               
                 tgccttctng naaccctgga agcccngnga cagtgttaca tgttgttcta nnaaacngac    660 
               
               
                   
               
               
                 ncttnaatnt cnatcttccc nanaacgatt ncncc                               695 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 16 
               
               
                 &lt;211&gt; LENGTH: 669 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (299) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (354) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (483) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (555) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (571) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (573) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (577) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (642) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (651) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (662) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (667) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 16 
               
               
                   
               
               
                 cgccgaagca gcagcgcagg ttgtccccgt ttcccctccc ccttcccttc tccggttgcc     60 
               
               
                   
               
               
                 ttcccgggcc ccttacactc cacagtcccg gtcccgccat gtcccagaaa caagaagaag    120 
               
               
                   
               
               
                 agaaccctgc ggaggagacc ggcgaggaga agcaggacac gcaggagaaa gaaggtattc    180 
               
               
                   
               
               
                 tgcctgagag agctgaagag gcaaagctaa aggccaaata cccaagccta ggacaaaagc    240 
               
               
                   
               
               
                 ctggaggctc cgacttcctc atgaagagac tccagaaagg gcaaaagtac tttgactcng    300 
               
               
                   
               
               
                 gagactacaa catggccaaa gccaacatga agaataagca gctgccaagt gcangaccag    360 
               
               
                   
               
               
                 acaagaacct ggtgactggt gatcacatcc ccaccccaca ggatctgccc agagaaagtc    420 
               
               
                   
               
               
                 ctcgctcgtc accagcaagc ttgcgggtgg ccaagttgaa tgatgctgcc ggggctctgc    480 
               
               
                   
               
               
                 canatctgag acgcttccct ccctgcccca cccgggtcct gtgctggctc ctgcccttcc    540 
               
               
                   
               
               
                 tgcttttgca gccangggtc aggaagtggc ncnggtngtg gctggaaagc aaaacccttt    600 
               
               
                   
               
               
                 cctgttggtg tcccacccat ggagcccctg gggcgagccc angaacttga ncctttttgt    660 
               
               
                   
               
               
                 tntcttncc                                                            669 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 17 
               
               
                 &lt;211&gt; LENGTH: 697 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (33) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (48) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (50) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (58) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (59) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (60) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (76) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (77) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (78) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (90) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (113) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (118) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (130) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (135) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (141) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (143) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (150) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (156) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (166) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (167) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (170) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (172) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (180) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (181) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (190) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (192) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (194) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (199) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (201) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (209) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (211) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (224) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (225) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (226) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (230) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (233) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (234) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (236) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (242) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (244) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (251) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (253) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (256) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (268) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (297) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (305) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (308) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (311) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (314) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (315) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (317) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (322) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (324) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (327) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (333) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (337) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (343) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (362) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (364) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (367) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (368) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (373) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (384) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (388) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (394) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (406) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (411) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (413) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (423) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (429) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (438) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (449) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (450) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (473) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (476) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (479) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (489) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (491) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (494) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (499) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (505) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (507) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (508) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (522) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (523) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (527) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (530) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (533) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (535) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (538) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (539) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (545) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (548) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (550) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (552) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (555) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (562) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (563) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (566) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (568) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (572) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (577) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (578) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (580) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (581) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (591) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (594) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (622) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (628) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (632) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (638) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (642) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (644) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (653) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (658) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (662) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (663) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (665) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (669) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (675) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (680) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (686) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (689) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 17 
               
               
                   
               
               
                 gcaagatatg gacaactaag tgagaaggta atnctctact gctctagntn ctccnggcnn     60 
               
               
                   
               
               
                 gacgcgctga ggagannnac gctggcccan ctgccggcca cacacgggga tcntggtnat    120 
               
               
                   
               
               
                 gcctgcccan gggancccca ncnctcggan cccatntcac acccgnnccn tncgcccacn    180 
               
               
                   
               
               
                 ncctggctcn cncngcccng nccagctcnc gnccccctcc gccnnnctcn ttnncntctc    240 
               
               
                   
               
               
                 cncnccctcc ncnacnacct cctacccncg gctccctccc cagccccccc ccgcaancct    300 
               
               
                   
               
               
                 ccacnacncc ntcnncncga ancnccnctc gcnctcngcc ccngccccct gccccccgcc    360 
               
               
                   
               
               
                 cncnacnncg cgntcccccg cgcncgcngc ctcnccccct cccacnacag ncncacccgc    420 
               
               
                   
               
               
                 agncacgcnc tccgcccnct gacgccccnn cccgccgcgc tcaccttcat ggnccnacng    480 
               
               
                   
               
               
                 ccccgctcnc nccnctgcnc gccgncnngg cgccccgccc cnnccgngtn ccncncgnng    540 
               
               
                   
               
               
                 ccccngcngn angcngtgcg cnncangncc gngccgnncn ncaccctccg nccnccgccc    600 
               
               
                   
               
               
                 cgcccgctgg gggctcccgc cncgcggntc antccccncc cntncgccca ctntccgntc    660 
               
               
                   
               
               
                 cnncnctcnc gctcngcgcn cgcccnccnc ccccccc                             697 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 18 
               
               
                 &lt;211&gt; LENGTH: 670 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (234) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (292) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (329) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (437) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (458) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (478) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (487) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (524) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (542) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (549) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (550) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (557) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (576) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (597) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (603) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (604) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (646) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (665) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 18 
               
               
                   
               
               
                 ctcgtgtgaa gggtgcagta cctaagccgg agcggggtag aggcgggccg gcaccccctt     60 
               
               
                   
               
               
                 ctgacctcca gtgccgccgg cctcaagatc agacatggcc cagaacttga acgacttggc    120 
               
               
                   
               
               
                 gggacggctg cccgccgggc cccggggcat gggcacggcc ctgaagctgt tgctgggggc    180 
               
               
                   
               
               
                 cggcgccgtg gcctacggtg tgcgcgaatc tgtgttcacc gtggaaggcg ggcncagagc    240 
               
               
                   
               
               
                 catcttcttc aatcggatcg gtggagtgca caggacacta tcctgggccg anggccttca    300 
               
               
                   
               
               
                 cttcaggatc cttggttcca gtaccccanc atctatgaca ttcgggccag acctcgaaaa    360 
               
               
                   
               
               
                 aatctcctcc ctacaggctc caaagaccta cagatggtga atatctccct gcgagtgttg    420 
               
               
                   
               
               
                 tctcgaccaa tgctcangaa cttcctaaca tgttccancg cctaagggct ggactacnaa    480 
               
               
                   
               
               
                 gaacgantgt tgccgtccat tgtcacgaag tgctcaagaa tttnggtggc caagttcaat    540 
               
               
                   
               
               
                 gncctcacnn ctgatcnccc agcggggcca agttanccct ggttgatccc cgggganctg    600 
               
               
                   
               
               
                 acnnaaaagg gccaaggact tcccctcatc ctggataatg tggccntcac aaagctcaac    660 
               
               
                   
               
               
                 tttanccacc                                                           670 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 19 
               
               
                 &lt;211&gt; LENGTH: 606 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (506) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 19 
               
               
                   
               
               
                 actagtgcca acctcagctc ccaggccagt tctctgaatg tcgaggagtt ccaggatctc     60 
               
               
                   
               
               
                 tggcctcagt tgtccttggt tattgatggg ggacaaattg gggatggcca gagccccgag    120 
               
               
                   
               
               
                 tgtcgccttg gctcaactgt ggttgatttg tctgtgcccg gaaagtttgg catcattcgt    180 
               
               
                   
               
               
                 ccaggctgtg ccctggaaag tactacagcc atcctccaac agaagtacgg actgctcccc    240 
               
               
                   
               
               
                 tcacatgcgt cctacctgtg aaactctggg aagcaggaag gcccaagacc tggtgctgga    300 
               
               
                   
               
               
                 tactatgtgt ctgtccactg acgactgtca aggcctcatt tgcagaggcc accggagcta    360 
               
               
                   
               
               
                 gggcactagc ctgactttta aggcagtgtg tctttctgag cactgtagac caagcccttg    420 
               
               
                   
               
               
                 gagctgctgg tttagccttg cacctgggga aaggatgtat ttatttgtat tttcatatat    480 
               
               
                   
               
               
                 cagccaaaag ctgaatggaa aagttnagaa cattcctagg tggccttatt ctaataagtt    540 
               
               
                   
               
               
                 tcttctgtct gttttgtttt tcaattgaaa agttattaaa taacagattt agaatctagt    600 
               
               
                   
               
               
                 gagacc                                                               606 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 20 
               
               
                 &lt;211&gt; LENGTH: 449 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 20 
               
               
                   
               
               
                 actagtaaac aacagcagca gaaacatcag tatcagcagc gtcgccagca ggagaatatg     60 
               
               
                   
               
               
                 cagcgccaga gccgaggaga acccccgctc cctgaggagg acctgtccaa actcttcaaa    120 
               
               
                   
               
               
                 ccaccacagc cgcctgccag gatggactcg ctgctcattg caggccagat aaacacttac    180 
               
               
                   
               
               
                 tgccagaaca tcaaggagtt cactgcccaa aacttaggca agctcttcat ggcccaggct    240 
               
               
                   
               
               
                 cttcaagaat acaacaacta agaaaaggaa gtttccagaa aagaagttaa catgaactct    300 
               
               
                   
               
               
                 tgaagtcaca ccagggcaac tcttggaaga aatatatttg catattgaaa agcacagagg    360 
               
               
                   
               
               
                 atttctttag tgtcattgcc gattttggct ataacagtgt ctttctagcc ataataaaat    420 
               
               
                   
               
               
                 aaaacaaaat cttgactgct tgctcaaaa                                      449 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 21 
               
               
                 &lt;211&gt; LENGTH: 409 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 21 
               
               
                   
               
               
                 tatcaatcaa ctggtgaata attaaacaat gtgtggtgtg atcatacaaa gggtaccact     60 
               
               
                   
               
               
                 caatgataaa aggaacaagc tgcctatatg tggaacaaca tggatgcatt tcagaaactt    120 
               
               
                   
               
               
                 tatgttgagt gaaagaacaa acacggagaa catactatgt ggttctcttt atgtaacatt    180 
               
               
                   
               
               
                 acagaaataa aaacagaggc aaccaccttt gaggcagtat ggagtgagat agactggaaa    240 
               
               
                   
               
               
                 aaggaaggaa ggaaactcta cgctgatgga aatgtctgtg tcttcattgg gtggtagtta    300 
               
               
                   
               
               
                 tgtggggata tacatttgtc aaaatttatt gaactatata ctaaagaact ctgcatttta    360 
               
               
                   
               
               
                 ttgggatgta aataatacct caattaaaaa gacaaaaaaa aaaaaaaaa                409 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 22 
               
               
                 &lt;211&gt; LENGTH: 649 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (263) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (353) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (610) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (635) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (646) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 22 
               
               
                   
               
               
                 acaattttca ttatcttaag cacattgtac atttctacag aacctgtgat tattctcgca     60 
               
               
                   
               
               
                 tgataaggat ggtacttgca tatggtgaat tactactgtt gacagtttcc gcagaaatcc    120 
               
               
                   
               
               
                 tatttcagtg gaccaacatt gtggcatggc agcaaatgcc aacattttgt ggaatagcag    180 
               
               
                   
               
               
                 caaatctaca agagaccctg gttggttttt cgttttgttt tctttgtttt ttcccccttc    240 
               
               
                   
               
               
                 tcctgaatca gcagggatgg aangagggta gggaagttat gaattactcc ttccagtagt    300 
               
               
                   
               
               
                 agctctgaag tgtcacattt aatatcagtt ttttttaaac atgattctag ttnaatgtag    360 
               
               
                   
               
               
                 aagagagaag aaagaggaag tgttcacttt tttaatacac tgatttagaa atttgatgtc    420 
               
               
                   
               
               
                 ttatatcagt agttctgagg tattgatagc ttgctttatt tctgccttta cgttgacagt    480 
               
               
                   
               
               
                 gttgaagcag ggtgaataac taggggcata tatatttttt ttttttgtaa gctgtttcat    540 
               
               
                   
               
               
                 gatgttttct ttggaatttc cggataagtt caggaaaaca tctgcatgtt gttatctagt    600 
               
               
                   
               
               
                 ctgaagttcn tatccatctc attacaacaa aaacncccag aacggnttg                649 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 23 
               
               
                 &lt;211&gt; LENGTH: 669 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (642) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (661) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 23 
               
               
                   
               
               
                 actagtgccg tactggctga aatccctgca ggaccaggaa gagaaccagt tcagactttg     60 
               
               
                   
               
               
                 tactctcagt caccagctct ggaattagat aaattccttg aagatgtcag gaatgggatc    120 
               
               
                   
               
               
                 tatcctctga cagcctttgg gctgcctcgg ccccagcagc cacagcagga ggaggtgaca    180 
               
               
                   
               
               
                 tcacctgtcg tgcccccctc tgtcaagact ccgacacctg aaccagctga ggtggagact    240 
               
               
                   
               
               
                 cgcaaggtgg tgctgatgca gtgcaacatt gagtcggtgg aggagggagt caaacaccac    300 
               
               
                   
               
               
                 ctgacacttc tgctgaagtt ggaggacaaa ctgaaccggc acctgagctg tgacctgatg    360 
               
               
                   
               
               
                 ccaaatgaga atatccccga gttggcggct gagctggtgc agctgggctt cattagtgag    420 
               
               
                   
               
               
                 gctgaccaga gccggttgac ttctctgcta gaagagactt gaacaagttc aattttgcca    480 
               
               
                   
               
               
                 ggaacagtac cctcaactca gccgctgtca ccgtctcctc ttagagctca ctcgggccag    540 
               
               
                   
               
               
                 gccctgatct gcgctgtggc tgtcctggac gtgctgcacc ctctgtcctt ccccccagtc    600 
               
               
                   
               
               
                 agtattacct gtgaagccct tccctccttt attattcagg anggctgggg gggctccttg    660 
               
               
                   
               
               
                 nttctaacc                                                            669 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 24 
               
               
                 &lt;211&gt; LENGTH: 442 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 24 
               
               
                   
               
               
                 actagtacca tcttgacaga ggatacatgc tcccaaaacg tttgttacca cacttaaaaa     60 
               
               
                   
               
               
                 tcactgccat cattaagcat cagtttcaaa attatagcca ttcatgattt actttttcca    120 
               
               
                   
               
               
                 gatgactatc attattctag tcctttgaat ttgtaagggg aaaaaaaaca aaaacaaaaa    180 
               
               
                   
               
               
                 cttacgatgc acttttctcc agcacatcag atttcaaatt gaaaattaaa gacatgctat    240 
               
               
                   
               
               
                 ggtaatgcac ttgctagtac tacacacttt ggtacaacaa aaaacagagg caagaaacaa    300 
               
               
                   
               
               
                 cggaaagaga aaagccttcc tttgttggcc cttaaactga gtcaagatct gaaatgtaga    360 
               
               
                   
               
               
                 gatgatctct gacgatacct gtatgttctt attgtgtaaa taaaattgct ggtatgaaat    420 
               
               
                   
               
               
                 gacctaaaaa aaaaaaaaga aa                                             442 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 25 
               
               
                 &lt;211&gt; LENGTH: 656 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (330) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (342) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (418) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (548) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (579) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (608) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 25 
               
               
                   
               
               
                 tgcaagtacc acacactgtt tgaattttgc acaaaaagtg actgtaggat caggtgatag     60 
               
               
                   
               
               
                 ccccggaatg tacagtgtct tggtgcacca agatgccttc taaaggctga cataccttgg    120 
               
               
                   
               
               
                 accctaatgg ggcagagagt atagccctag cccagtggtg acatgaccac tccctttggg    180 
               
               
                   
               
               
                 aggcctgagg tagaggggag tggtatgtgt tttctcagtg gaagcagcac atgagtgggt    240 
               
               
                   
               
               
                 gacaggatgt tagataaagg ctctagttag ggtgtcattg tcatttgaga gactgacaca    300 
               
               
                   
               
               
                 ctcctagcag ctggtaaagg ggtgctggan gccatggagg anctctagaa acattagcat    360 
               
               
                   
               
               
                 gggctgatct gattacttcc tggcatcccg ctcactttta tgggaagtct tattagangg    420 
               
               
                   
               
               
                 atgggacagt tttccatatc cttgctgtgg agctctggaa cactctctaa atttccctct    480 
               
               
                   
               
               
                 attaaaaatc actgccctaa ctacacttcc tccttgaagg aatagaaatg gaactttctc    540 
               
               
                   
               
               
                 tgacatantt cttggcatgg ggagccagcc acaaatgana atctgaacgt gtccaggttt    600 
               
               
                   
               
               
                 ctcctganac tcatctacat agaattggtt aaaccctccc ttggaataag gaaaaa        656 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 26 
               
               
                 &lt;211&gt; LENGTH: 434 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (395) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 26 
               
               
                   
               
               
                 actagttcag actgccacgc caaccccaga aaatacccca catgccagaa aagtgaagtc     60 
               
               
                   
               
               
                 ctaggtgttt ccatctatgt ttcaatctgt ccatctacca ggcctcgcga taaaaacaaa    120 
               
               
                   
               
               
                 acaaaaaaac gctgccaggt tttagaagca gttctggtct caaaaccatc aggatcctgc    180 
               
               
                   
               
               
                 caccagggtt cttttgaaat agtaccacat gtaaaaggga atttggcttt cacttcatct    240 
               
               
                   
               
               
                 aataactgaa ttgtcaggct ttgattgata attgtagaaa taagtagcct tctgttgtgg    300 
               
               
                   
               
               
                 gaataagtta taatcagtat tcatctcttt gttttttgtc actcttttct ctctaattgt    360 
               
               
                   
               
               
                 gtcatttgta ctgtttgaaa aatatttctt ctatnaaatt aaactaacct gccttaaaaa    420 
               
               
                   
               
               
                 aaaaaaaaaa aaaa                                                      434 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 27 
               
               
                 &lt;211&gt; LENGTH: 654 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (505) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (533) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (563) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (592) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (613) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (635) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (638) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 27 
               
               
                   
               
               
                 actagtccaa cacagtcaga aacattgttt tgaatcctct gtaaaccaag gcattaatct     60 
               
               
                   
               
               
                 taataaacca ggatccattt aggtaccact tgatataaaa aggatatcca taatgaatat    120 
               
               
                   
               
               
                 tttatactgc atcctttaca ttagccacta aatacgttat tgcttgatga agacctttca    180 
               
               
                   
               
               
                 cagaatccta tggattgcag catttcactt ggctacttca tacccatgcc ttaaagaggg    240 
               
               
                   
               
               
                 gcagtttctc aaaagcagaa acatgccgcc agttctcaag ttttcctcct aactccattt    300 
               
               
                   
               
               
                 gaatgtaagg gcagctggcc cccaatgtgg ggaggtccga acattttctg aattcccatt    360 
               
               
                   
               
               
                 ttcttgttcg cggctaaatg acagtttctg tcattactta gattccgatc tttcccaaag    420 
               
               
                   
               
               
                 gtgttgattt acaaagaggc cagctaatag cagaaatcat gaccctgaaa gagagatgaa    480 
               
               
                   
               
               
                 attcaagctg tgagccaggc agganctcag tatggcaaag gtcttgagaa tcngccattt    540 
               
               
                   
               
               
                 ggtacaaaaa aaattttaaa gcntttatgt tataccatgg aaccatagaa anggcaaggg    600 
               
               
                   
               
               
                 aattgttaag aanaatttta agtgtccaga cccanaanga aaaaaaaaaa aaaa          654 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 28 
               
               
                 &lt;211&gt; LENGTH: 670 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (101) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (226) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (274) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (330) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (385) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (392) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (397) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (402) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (452) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (473) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (476) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (532) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (534) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (538) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (550) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (583) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (595) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (604) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (613) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (622) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (643) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (669) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 28 
               
               
                   
               
               
                 cgtgtgcaca tactgggagg atttccacag ctgcacggtc acagccctta cggattgcca     60 
               
               
                   
               
               
                 ggaaggggcg aaagatatgt gggataaact gagaaaagaa nccaaaaacc tcaacatcca    120 
               
               
                   
               
               
                 aggcagctta ttcgaactct gcggcagcgg caacggggcg gcggggtccc tgctcccggc    180 
               
               
                   
               
               
                 gttcccggtg ctcctggtgt ctctctcggc agctttagcg acctgncttt ccttctgagc    240 
               
               
                   
               
               
                 gtggggccag ctccccccgc ggcgcccacc cacnctcact ccatgctccc ggaaatcgag    300 
               
               
                   
               
               
                 aggaagatca ttagttcttt ggggacgttn gtgattctct gtgatgctga aaaacactca    360 
               
               
                   
               
               
                 tatagggaat gtgggaaatc ctganctctt tnttatntcg tntgatttct tgtgttttat    420 
               
               
                   
               
               
                 ttgccaaaat gttaccaatc agtgaccaac cnagcacagc caaaaatcgg acntcngctt    480 
               
               
                   
               
               
                 tagtccgtct tcacacacag aataagaaaa cggcaaaccc accccacttt tnantttnat    540 
               
               
                   
               
               
                 tattactaan ttttttctgt tgggcaaaag aatctcagga acngccctgg ggccnccgta    600 
               
               
                   
               
               
                 ctanagttaa ccnagctagt tncatgaaaa atgatgggct ccncctcaat gggaaagcca    660 
               
               
                   
               
               
                 agaaaaagnc                                                           670 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 29 
               
               
                 &lt;211&gt; LENGTH: 551 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (336) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (474) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (504) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (511) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (522) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (523) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (524) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (540) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (547) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 29 
               
               
                   
               
               
                 actagtcctc cacagcctgt gaatccccct agacctttca agcatagtga gcggagaaga     60 
               
               
                   
               
               
                 agatctcagc gtttagccac cttacccatg cctgatgatt ctgtagaaaa ggtttcttct    120 
               
               
                   
               
               
                 ccctctccag ccactgatgg gaaagtattc tccatcagtt ctcaaaatca gcaagaatct    180 
               
               
                   
               
               
                 tcagtaccag aggtgcctga tgttgcacat ttgccacttg agaagctggg accctgtctc    240 
               
               
                   
               
               
                 cctcttgact taagtcgtgg ttcagaagtt acagcaccgg tagcctcaga ttcctcttac    300 
               
               
                   
               
               
                 cgtaatgaat gtcccagggc agaaaaagag gatacncaga tgcttccaaa tccttcttcc    360 
               
               
                   
               
               
                 aaagcaatag ctgatgggaa gaggagctcc agcagcagca ggaatatcga aaacagaaaa    420 
               
               
                   
               
               
                 aaaagtgaaa ttgggaagac aaaagctcaa cagcatttgg taaggagaaa aganaagatg    480 
               
               
                   
               
               
                 aggaaggaag agagaagaga gacnaagatc nctacggacc gnnncggaag aagaagaagn    540 
               
               
                   
               
               
                 aaaaaanaaa a                                                         551 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 30 
               
               
                 &lt;211&gt; LENGTH: 684 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (545) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (570) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (606) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (657) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (684) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 30 
               
               
                   
               
               
                 actagttcta tctggaaaaa gcccgggttg gaagaagctg tggagagtgc gtgtgcaatg     60 
               
               
                   
               
               
                 cgagactcat ttcttggaag catccctggc aaaaatgcag ctgagtacaa ggttatcact    120 
               
               
                   
               
               
                 gtgatagaac ctggactgct ttttgagata atagagatgc tgcagtctga agagacttcc    180 
               
               
                   
               
               
                 agcacctctc agttgaatga attaatgatg gcttctgagt caactttact ggctcaggaa    240 
               
               
                   
               
               
                 ccacgagaga tgactgcaga tgtaatcgag cttaaaggga aattcctcat caacttagaa    300 
               
               
                   
               
               
                 ggtggtgata ttcgtgaaga gtcttcctat aaagtaattg tcatgccgac tacgaaagaa    360 
               
               
                   
               
               
                 aaatgccccc gttgttggaa gtatacagcg ggagtcttca gatacactgt gtcctcgatg    420 
               
               
                   
               
               
                 tgcagaagtt gtcagtggga aaatagtatt aacagctcac tcgagcaaga accctcctga    480 
               
               
                   
               
               
                 cagtactggg ctagaagttt ggatggatta tttacaatat aggaaagaaa gccaagaatt    540 
               
               
                   
               
               
                 aggtnatgag tggatgagta aatggtggan gatggggaat tcaaatcaga attatggaag    600 
               
               
                   
               
               
                 aagttnttcc tgttactata gaaaggaatt atgtttattt acatgcagaa aatatanatg    660 
               
               
                   
               
               
                 tgtggtgtgt accgtggatg gaan                                           684 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 31 
               
               
                 &lt;211&gt; LENGTH: 654 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (326) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (582) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (651) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 31 
               
               
                   
               
               
                 gcgcagaaaa ggaaccaata tttcagaaac aagcttaata ggaacagctg cctgtacatc     60 
               
               
                   
               
               
                 aacatcttct cagaatgacc cagaagttat catcgtggga gctggcgtgc ttggctctgc    120 
               
               
                   
               
               
                 tttggcagct gtgctttcca gagatggaag aaaggtgaca gtcattgaga gagacttaaa    180 
               
               
                   
               
               
                 agagcctgac agaatagttg gagaattcct gcagccgggt ggttatcatg ttctcaaaga    240 
               
               
                   
               
               
                 ccttggtctt ggagatacag tggaaggtct tgatgcccag gttgtaaatg gttacatgat    300 
               
               
                   
               
               
                 tcatgatcag ggaaagcaaa tcagangttc agattcctta ccctctgtca gaaaacaatc    360 
               
               
                   
               
               
                 aagtgcagag tggaagagct ttccatcacg gaagattcat catgagtctc cggaaagcag    420 
               
               
                   
               
               
                 ctatggcaga gcccaatgca aagtttattg aaggtgttgt gttacagtta ttagaggaag    480 
               
               
                   
               
               
                 atgatgttgt gatgggagtt cagtacaagg ataaagagac tgggagatat caaggaactc    540 
               
               
                   
               
               
                 catgctccac tgactgttgt tgcagatggg cttttctcca anttcaggaa aagcctggtc    600 
               
               
                   
               
               
                 tcaataaagt ttctgtatca ctcatttggt tggcttctta tgaagaatgc nccc          654 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 32 
               
               
                 &lt;211&gt; LENGTH: 673 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (376) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (545) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (627) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 32 
               
               
                   
               
               
                 actagtgaag aaaaagaaat tctgatacgg gacaaaaatg ctcttcaaaa catcattctt     60 
               
               
                   
               
               
                 tatcacctga caccaggagt tttcattgga aaaggatttg aacctggtgt tactaacatt    120 
               
               
                   
               
               
                 ttaaagacca cacaaggaag caaaatcttt ctgaaagaag taaatgatac acttctggtg    180 
               
               
                   
               
               
                 aatgaattga aatcaaaaga atctgacatc atgacaacaa atggtgtaat tcatgttgta    240 
               
               
                   
               
               
                 gataaactcc tctatccagc agacacacct gttggaaatg atcaactgct ggaaatactt    300 
               
               
                   
               
               
                 aataaattaa tcaaatacat ccaaattaag tttgttcgtg gtagcacctt caaagaaatc    360 
               
               
                   
               
               
                 cccgtgactg tctatnagcc aattattaaa aaatacacca aaatcattga tgggagtgcc    420 
               
               
                   
               
               
                 tgtgggaaat aactgaaaaa gagaccgaga agaacgaatc attacaggtc ctgaaataaa    480 
               
               
                   
               
               
                 atacctagga tttctactgg aggtggagaa acagaagaac tctgaagaaa ttgttacaag    540 
               
               
                   
               
               
                 aagangtccc aaggtcacca aattcattga aggtggtgat ggtctttatt tgaagatgaa    600 
               
               
                   
               
               
                 gaaattaaaa gacgcttcag ggagacnccc catgaaggaa ttgccagcca caaaaaaatt    660 
               
               
                   
               
               
                 cagggattag aaa                                                       673 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 33 
               
               
                 &lt;211&gt; LENGTH: 673 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (325) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (419) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (452) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (532) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (538) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (542) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (571) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (600) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (616) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (651) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (653) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (672) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 33 
               
               
                   
               
               
                 actagttatt tactttcctc cgcttcagaa ggtttttcag actgagagcc taagcatact     60 
               
               
                   
               
               
                 ggatctgttg tttcttttgg gtctcacctc atcagtgtgc atagtggcag aaattataaa    120 
               
               
                   
               
               
                 gaaggttgaa aggagcaggg aaaagatcca gaagcatgtt agttcgacat catcatcttt    180 
               
               
                   
               
               
                 tcttgaagta tgatgcatat tgcattattt tatttgcaaa ctaggaattg cagtctgagg    240 
               
               
                   
               
               
                 atcatttaga agggcaagtt caagaggata tgaagatttg agaacttttt aactattcat    300 
               
               
                   
               
               
                 tgactaaaaa tgaacattaa tgttnaagac ttaagacttt aacctgctgg cagtcccaaa    360 
               
               
                   
               
               
                 tgaaattatg caactttgat atcatattcc ttgatttaaa ttgggctttt gtgattgant    420 
               
               
                   
               
               
                 gaaactttat aaagcatatg gtcagttatt tnattaaaaa ggcaaaacct gaaccacctt    480 
               
               
                   
               
               
                 ctgcacttaa agaagtctaa cagtacaaat acctatctat cttagatgga tntatttntt    540 
               
               
                   
               
               
                 tntattttta aatattgtac tatttatggt nggtggggct ttcttactaa tacacaaatn    600 
               
               
                   
               
               
                 aatttatcat ttcaanggca ttctatttgg gtttagaagt tgattccaag nantgcatat    660 
               
               
                   
               
               
                 ttcgctactg tnt                                                       673 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 34 
               
               
                 &lt;211&gt; LENGTH: 684 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (414) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (472) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (480) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (490) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (503) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (507) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (508) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (513) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (523) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (574) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (575) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (598) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (659) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (662) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (675) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 34 
               
               
                   
               
               
                 actagtttat tcaagaaaag aacttactga ttcctctgtt cctaaagcaa gagtggcagg     60 
               
               
                   
               
               
                 tgatcagggc tggtgtagca tccggttcct ttagtgcagc taactgcatt tgtcactgat    120 
               
               
                   
               
               
                 gaccaaggag gaaatcacta agacatttga gaagcagtgg tatgaacgtt cttggacaag    180 
               
               
                   
               
               
                 ccacagttct gagccttaac cctgtagttt gcacacaaga acgagctcca cctccccttc    240 
               
               
                   
               
               
                 ttcaggagga atctgtgcgg atagattggc tggacttttc aatggttctg ggttgcaagt    300 
               
               
                   
               
               
                 gggcactgtt atggctgggt atggagcgga cagccccagg aatcagagcc tcagcccggc    360 
               
               
                   
               
               
                 tgcctggttg gaaggtacag gtgttcagca ccttcggaaa aagggcataa agtngtgggg    420 
               
               
                   
               
               
                 gacaattctc agtccaagaa gaatgcattg accattgctg gctatttgct tncctagtan    480 
               
               
                   
               
               
                 gaattggatn catttttgac cangatnntt ctnctatgct ttnttgcaat gaaatcaaat    540 
               
               
                   
               
               
                 cccgcattat ctacaagtgg tatgaagtcc tgcnnccccc agagaggctg ttcaggcnat    600 
               
               
                   
               
               
                 gtcttccaag ggcagggtgg gttacaccat tttacctccc ctctcccccc agattatgna    660 
               
               
                   
               
               
                 cncagaagga atttntttcc tccc                                           684 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 35 
               
               
                 &lt;211&gt; LENGTH: 614 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (17) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (20) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (152) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (223) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (267) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (287) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (304) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (306) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (316) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (319) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (321) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (355) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (365) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (382) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (391) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (407) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (419) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (428) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (434) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (464) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (467) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (477) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (480) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (495) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (499) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (505) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (515) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (516) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (522) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (524) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (527) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (542) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (547) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (549) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (567) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (572) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (576) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (578) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 35 
               
               
                   
               
               
                 actagtccaa cgcgttngcn aatattcccc tggtagccta cttccttacc cccgaatatt     60 
               
               
                   
               
               
                 ggtaagatcg agcaatggct tcaggacatg ggttctcttc tcctgtgatc attcaagtgc    120 
               
               
                   
               
               
                 tcactgcatg aagactggct tgtctcagtg tntcaacctc accagggctg tctcttggtc    180 
               
               
                   
               
               
                 cacacctcgc tccctgttag tgccgtatga cagcccccat canatgacct tggccaagtc    240 
               
               
                   
               
               
                 acggtttctc tgtggtcaat gttggtnggc tgattggtgg aaagtanggt ggaccaaagg    300 
               
               
                   
               
               
                 aagncncgtg agcagncanc nccagttctg caccagcagc gcctccgtcc tactngggtg    360 
               
               
                   
               
               
                 ttccngtttc tcctggccct gngtgggcta nggcctgatt cgggaanatg cctttgcang    420 
               
               
                   
               
               
                 gaaggganga taantgggat ctaccaattg attctggcaa aacnatntct aagattnttn    480 
               
               
                   
               
               
                 tgctttatgt ggganacana tctanctctc atttnntgct gnanatnaca ccctactcgt    540 
               
               
                   
               
               
                 gntcgancnc gtcttcgatt ttcgganaca cnccantnaa tactggcgtt ctgttgttaa    600 
               
               
                   
               
               
                 aaaaaaaaaa aaaa                                                      614 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 36 
               
               
                 &lt;211&gt; LENGTH: 686 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (222) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (224) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (237) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (264) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (285) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (548) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (551) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (628) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (643) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (645) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (665) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (674) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 36 
               
               
                   
               
               
                 gtggctggcc cggttctccg cttctcccca tcccctactt tcctccctcc ctccctttcc     60 
               
               
                   
               
               
                 ctccctcgtc gactgttgct tgctggtcgc agactccctg acccctccct cacccctccc    120 
               
               
                   
               
               
                 taacctcggt gccaccggat tgcccttctt ttcctgttgc ccagcccagc cctagtgtca    180 
               
               
                   
               
               
                 gggcgggggc ctggagcagc ccgaggcact gcagcagaag ananaaaaga cacgacnaac    240 
               
               
                   
               
               
                 ctcagctcgc cagtccggtc gctngcttcc cgccgcatgg caatnagaca gacgccgctc    300 
               
               
                   
               
               
                 acctgctctg ggcacacgcg acccgtggtt gatttggcct tcagtggcat cacccttatg    360 
               
               
                   
               
               
                 ggtatttctt aatcagcgct tgcaaagatg gttaacctat gctacgccag ggagatacag    420 
               
               
                   
               
               
                 gagactggat tggaacattt ttggggtcta aaggtctgtt tggggtgcaa cactgaataa    480 
               
               
                   
               
               
                 ggatgccacc aaagcagcta cagcagctgc agatttcaca gcccaagtgt gggatgctgt    540 
               
               
                   
               
               
                 ctcagganat naattgataa cctggctcat aacacattgt caagaatgtg gatttcccca    600 
               
               
                   
               
               
                 ggatattatt atttgtttac cggggganag gataactgtt tcncntattt taattgaaca    660 
               
               
                   
               
               
                 aactnaaaca aaanctaagg aaatcc                                         686 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 37 
               
               
                 &lt;211&gt; LENGTH: 681 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (7) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (10) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (11) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (19) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (25) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (32) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (46) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (53) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (77) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (93) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (101) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (103) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (109) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (115) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (123) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (128) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (139) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (157) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (175) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (180) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (192) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (193) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (194) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (212) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (218) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (226) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (227) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (233) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (240) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (241) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (259) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (260) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (267) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (288) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (296) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (297) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (298) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (312) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (313) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (314) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (320) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (325) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (330) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (337) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (345) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (346) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (352) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (353) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (356) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (382) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (385) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (400) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (427) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (481) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (484) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (485) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (491) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (505) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (515) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (533) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (542) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (544) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (554) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (557) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (560) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (561) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (564) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (575) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (583) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (589) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (595) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (607) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (619) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (628) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (634) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (640) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (645) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (657) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (670) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 37 
               
               
                   
               
               
                 gagacanacn naacgtcang agaanaaaag angcatggaa cacaanccag gcncgatggc     60 
               
               
                   
               
               
                 caccttccca ccagcancca gcgcccccca gcngccccca ngnccggang accangactc    120 
               
               
                   
               
               
                 cancctgnat caatctganc tctattcctg gcccatncct acctcggagg tggangccgn    180 
               
               
                   
               
               
                 aaaggtcgca cnnncagaga agctgctgcc ancaccancc gccccnnccc tgncgggctn    240 
               
               
                   
               
               
                 nataggaaac tggtgaccnn gctgcanaat tcatacagga gcacgcgang ggcacnnnct    300 
               
               
                   
               
               
                 cacactgagt tnnngatgan gcctnaccan ggacctnccc cagcnnattg annacnggac    360 
               
               
                   
               
               
                 tgcggaggaa ggaagacccc gnacnggatc ctggccggcn tgccaccccc ccacccctag    420 
               
               
                   
               
               
                 gattatnccc cttgactgag tctctgaggg gctacccgaa cccgcctcca ttccctacca    480 
               
               
                   
               
               
                 natnntgctc natcgggact gacangctgg ggatnggagg ggctatcccc cancatcccc    540 
               
               
                   
               
               
                 tnanaccaac agcnacngan natnggggct ccccngggtc ggngcaacnc tcctncaccc    600 
               
               
                   
               
               
                 cggcgcnggc cttcggtgnt gtcctccntc aacnaattcc naaanggcgg gccccccngt    660 
               
               
                   
               
               
                 ggactcctcn ttgttccctc c                                              681 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 38 
               
               
                 &lt;211&gt; LENGTH: 687 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (3) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (30) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (132) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (151) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (203) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (226) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (228) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (233) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (252) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (264) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (279) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (306) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (308) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (320) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (340) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (347) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (400) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (407) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (4029) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (437) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (440) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (445) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (448) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (491) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (559) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (567) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (586) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (589) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (593) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (596) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (603) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (605) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (606) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (609) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (626) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (639) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (655) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (674) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (682) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 38 
               
               
                   
               
               
                 canaaaaaaa aaaacatggc cgaaaccagn aagctgcgcg atggcgccac ggcccctctt     60 
               
               
                   
               
               
                 ctcccggcct gtgtccggaa ggtttccctc cgaggcgccc cggctcccgc aagcggagga    120 
               
               
                   
               
               
                 gagggcggga cntgccgggg ccggagctca naggccctgg ggccgctctg ctctcccgcc    180 
               
               
                   
               
               
                 atcgcaaggg cggcgctaac ctnaggcctc cccgcaaagg tccccnangc ggnggcggcg    240 
               
               
                   
               
               
                 gggggctgtg anaaccgcaa aaanaacgct gggcgcgcng cgaacccgtc cacccccgcg    300 
               
               
                   
               
               
                 aaggananac ttccacagan gcagcgtttc cacagcccan agccacnttt ctagggtgat    360 
               
               
                   
               
               
                 gcaccccagt aagttcctgn cggggaagct caccgctgtc aaaaaanctc ttcgctccac    420 
               
               
                   
               
               
                 cggcgcacna aggggangan ggcangangc tgccgcccgc acaggtcatc tgatcacgtc    480 
               
               
                   
               
               
                 gcccgcccta ntctgctttt gtgaatctcc actttgttca accccacccg ccgttctctc    540 
               
               
                   
               
               
                 ctccttgcgc cttcctctna ccttaanaac cagcttcctc tacccnatng tanttnctct    600 
               
               
                   
               
               
                 gcncnngtng aaattaattc ggtccnccgg aacctcttnc ctgtggcaac tgctnaaaga    660 
               
               
                   
               
               
                 aactgctgtt ctgnttactg cngtccc                                        687 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 39 
               
               
                 &lt;211&gt; LENGTH: 695 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (300) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (401) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (423) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (429) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (431) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (437) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (443) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (448) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (454) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (466) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (492) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (515) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (523) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (524) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (536) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (538) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (541) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (552) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (561) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (566) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (581) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (583) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (619) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (635) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (636) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (641) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (649) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (661) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (694) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 39 
               
               
                   
               
               
                 actagtctgg cctacaatag tgtgattcat gtaggacttc tttcatcaat tcaaaacccc     60 
               
               
                   
               
               
                 tagaaaaacg tatacagatt atataagtag ggataagatt tctaacattt ctgggctctc    120 
               
               
                   
               
               
                 tgacccctgc gctagactgt ggaaagggag tattattata gtatacaaca ctgctgttgc    180 
               
               
                   
               
               
                 cttattagtt ataacatgat aggtgctgaa ttgtgattca caatttaaaa acactgtaat    240 
               
               
                   
               
               
                 ccaaactttt ttttttaact gtagatcatg catgtgaatg ttaatgttaa tttgttcaan    300 
               
               
                   
               
               
                 gttgttatgg gtagaaaaaa ccacatgcct taaaatttta aaaagcaggg cccaaactta    360 
               
               
                   
               
               
                 ttagtttaaa attaggggta tgtttccagt ttgttattaa ntggttatag ctctgtttag    420 
               
               
                   
               
               
                 aanaaatcna ngaacangat ttngaaantt aagntgacat tatttnccag tgacttgtta    480 
               
               
                   
               
               
                 atttgaaatc anacacggca ccttccgttt tggtnctatt ggnntttgaa tccaancngg    540 
               
               
                   
               
               
                 ntccaaatct tnttggaaac ngtccnttta acttttttac nanatcttat ttttttattt    600 
               
               
                   
               
               
                 tggaatggcc ctatttaang ttaaaagggg ggggnnccac naccattcnt gaataaaact    660 
               
               
                   
               
               
                 naatatatat ccttggtccc ccaaaattta aggng                               695 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 40 
               
               
                 &lt;211&gt; LENGTH: 674 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (403) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (428) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (432) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (507) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (530) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (543) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (580) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (583) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (591) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (604) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (608) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (621) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (624) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (626) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (639) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (672) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 40 
               
               
                   
               
               
                 actagtagtc agttgggagt ggttgctata ccttgacttc atttatatga atttccactt     60 
               
               
                   
               
               
                 tattaaataa tagaaaagaa aatcccggtg cttgcagtag agttatagga cattctatgc    120 
               
               
                   
               
               
                 ttacagaaaa tatagccatg attgaaatca aatagtaaag gctgttctgg ctttttatct    180 
               
               
                   
               
               
                 tcttagctca tcttaaataa gtagtacact tgggatgcag tgcgtctgaa gtgctaatca    240 
               
               
                   
               
               
                 gttgtaacaa tagcacaaat cgaacttagg atgtgtttct tctcttctgt gtttcgattt    300 
               
               
                   
               
               
                 tgatcaattc tttaattttg ggaacctata atacagtttt cctattcttg gagataaaaa    360 
               
               
                   
               
               
                 ttaaatggat cactgatatt taagtcattc tgcttctcat ctnaatattc catattctgt    420 
               
               
                   
               
               
                 attagganaa antacctccc agcacagccc cctctcaaac cccacccaaa accaagcatt    480 
               
               
                   
               
               
                 tggaatgagt ctcctttatt tccgaantgt ggatggtata acccatatcn ctccaatttc    540 
               
               
                   
               
               
                 tgnttgggtt gggtattaat ttgaactgtg catgaaaagn ggnaatcttt nctttgggtc    600 
               
               
                   
               
               
                 aaantttncc ggttaatttg nctngncaaa tccaatttnc tttaagggtg tctttataaa    660 
               
               
                   
               
               
                 atttgctatt cngg                                                      674 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 41 
               
               
                 &lt;211&gt; LENGTH: 657 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (243) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (247) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (251) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (261) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (267) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (272) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (298) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (312) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (315) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (421) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (432) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (434) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (501) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (524) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (569) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (594) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (607) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (650) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 41 
               
               
                   
               
               
                 gaaacatgca agtaccacac actgtttgaa ttttgcacaa aaagtgactg tagggatcag     60 
               
               
                   
               
               
                 gtgatagccc cggaatgtac agtgtcttgg tgcaccaaga tgccttctaa aggctgacat    120 
               
               
                   
               
               
                 accttgggac cctaatgggg cagagagtat agccctagcc cagtggtgac atgaccactc    180 
               
               
                   
               
               
                 cctttgggag gctgaagtta aagggaatgg tatgtgtttt ctcatggaag cagcacatga    240 
               
               
                   
               
               
                 atnggtnaca ngatgttaaa ntaaggntct antttgggtg tcttgtcatt tgaaaaantg    300 
               
               
                   
               
               
                 acacactcct ancanctggt aaaggggtgc tggaagccat ggaagaactc taaaaacatt    360 
               
               
                   
               
               
                 agcatgggct gatctgatta cttcctggca tcccgctcac ttttatggga agtcttatta    420 
               
               
                   
               
               
                 naaggatggg ananttttcc atatccttgc tgttggaact ctggaacact ctctaaattt    480 
               
               
                   
               
               
                 ccctctatta aaaatcactg nccttactac acttcctcct tganggaata gaaatggacc    540 
               
               
                   
               
               
                 tttctctgac ttagttcttg gcatggganc cagcccaaat taaaatctga cttntccggt    600 
               
               
                   
               
               
                 ttctccngaa ctcacctact tgaattggta aaacctcctt tggaattagn aaaaacc       657 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 42 
               
               
                 &lt;211&gt; LENGTH: 389 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (179) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (317) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (320) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 42 
               
               
                   
               
               
                 actagtgctg aggaatgtaa acaagtttgc tgggccttgc gagacttcac caggttgttt     60 
               
               
                   
               
               
                 cgatagctca cactcctgca ctgtgcctgt cacccaggaa tgtctttttt aattagaaga    120 
               
               
                   
               
               
                 caggaagaaa acaaaaacca gactgtgtcc cacaatcaga aacctccgtt gtggcagang    180 
               
               
                   
               
               
                 ggccttcacc gccaccaggg tgtcccgcca gacagggaga gactccagcc ttctgaggcc    240 
               
               
                   
               
               
                 atcctgaaga attcctgttt gggggttgtg aaggaaaatc acccggattt aaaaagatgc    300 
               
               
                   
               
               
                 tgttgcctgc ccgcgtngtn gggaagggac tggtttcctg gtgaatttct taaaagaaaa    360 
               
               
                   
               
               
                 atattttaag ttaagaaaaa aaaaaaaaa                                      389 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 43 
               
               
                 &lt;211&gt; LENGTH: 279 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 43 
               
               
                   
               
               
                 actagtgaca agctcctggt cttgagatgt cttctcgtta aggagatggg ccttttggag     60 
               
               
                   
               
               
                 gtaaaggata aaatgaatga gttctgtcat gattcactat tctagaactt gcatgacctt    120 
               
               
                   
               
               
                 tactgtgtta gctctttgaa tgttcttgaa attttagact ttctttgtaa acaaataata    180 
               
               
                   
               
               
                 tgtccttatc attgtataaa agctgttatg tgcaacagtg tggagatcct tgtctgattt    240 
               
               
                   
               
               
                 aataaaatac ttaaacactg aaaaaaaaaa aaaaaaaaa                           279 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 44 
               
               
                 &lt;211&gt; LENGTH: 449 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (245) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (256) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (264) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (266) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (273) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (281) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (323) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (325) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (337) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (393) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 44 
               
               
                   
               
               
                 actagtagca tcttttctac aacgttaaaa ttgcagaagt agcttatcat taaaaaacaa     60 
               
               
                   
               
               
                 caacaacaac aataacaata aatcctaagt gtaaatcagt tattctaccc cctaccaagg    120 
               
               
                   
               
               
                 atatcagcct gttttttccc ttttttctcc tgggaataat tgtgggcttc ttcccaaatt    180 
               
               
                   
               
               
                 tctacagcct ctttcctctt ctcatgcttg agcttccctg tttgcacgca tgcgttgtgc    240 
               
               
                   
               
               
                 aagantgggc tgtttngctt ggantncggt ccnagtggaa ncatgctttc ccttgttact    300 
               
               
                   
               
               
                 gttggaagaa actcaaacct tcnancccta ggtgttncca ttttgtcaag tcatcactgt    360 
               
               
                   
               
               
                 atttttgtac tggcattaac aaaaaaagaa atnaaatatt gttccattaa actttaataa    420 
               
               
                   
               
               
                 aactttaaaa gggaaaaaaa aaaaaaaaa                                      449 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 45 
               
               
                 &lt;211&gt; LENGTH: 559 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (263) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 45 
               
               
                   
               
               
                 actagtgtgg gggaatcacg gacacttaaa gtcaatctgc gaaataattc ttttattaca     60 
               
               
                   
               
               
                 cactcactga agtttttgag tcccagagag ccattctatg tcaaacattc caagtactct    120 
               
               
                   
               
               
                 ttgagagccc agcattacat caacatgccc gtgcagttca aaccgaagtc cgcaggcaaa    180 
               
               
                   
               
               
                 tttgaagctt tgcttgtcat tcaaacagat gaaggcaaga gtattgctat tcgactaatt    240 
               
               
                   
               
               
                 ggtgaagctc ttggaaaaaa ttnactagaa tactttttgt gttaagttaa ttacataagt    300 
               
               
                   
               
               
                 tgtattttgt taactttatc tttctacact acaattatgc ttttgtatat atattttgta    360 
               
               
                   
               
               
                 tgatggatat ctataattgt agattttgtt tttacaagct aatactgaag actcgactga    420 
               
               
                   
               
               
                 aatattatgt atctagccca tagtattgta cttaactttt acagggtgaa aaaaaaattc    480 
               
               
                   
               
               
                 tgtgtttgca ttgattatga tattctgaat aaatatggga atatatttta atgtgggtaa    540 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaggaa                                                 559 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 46 
               
               
                 &lt;211&gt; LENGTH: 731 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (270) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (467) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (477) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (502) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (635) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (660) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (671) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (688) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (695) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (697) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (725) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 46 
               
               
                   
               
               
                 actagttcta gtaccatggc tgtcatagat gcaaccatta tattccattt agtttcttcc     60 
               
               
                   
               
               
                 tcaggttccc taacaattgt ttgaaactga atatatatgt ttatgtatgt gtgtgtgttc    120 
               
               
                   
               
               
                 actgtcatgt atatggtgta tatgggatgt gtgcagtttt cagttatata tatattcata    180 
               
               
                   
               
               
                 tatacatatg catatatatg tataatatac atatatacat gcatacactt gtataatata    240 
               
               
                   
               
               
                 catatatata cacatatatg cacacatatn atcactgagt tccaaagtga gtctttattt    300 
               
               
                   
               
               
                 ggggcaattg tattctctcc ctctgtctgc tcactgggcc tttgcaagac atagcaattg    360 
               
               
                   
               
               
                 cttgatttcc tttggataag agtcttatct tcggcactct tgactctagc cttaacttta    420 
               
               
                   
               
               
                 gatttctatt ccagaatacc tctcatatct atcttaaaac ctaaganggg taaagangtc    480 
               
               
                   
               
               
                 ataagattgt agtatgaaag antttgctta gttaaattat atctcaggaa actcattcat    540 
               
               
                   
               
               
                 ctacaaatta aattgtaaaa tgatggtttg ttgtatctga aaaaatgttt agaacaagaa    600 
               
               
                   
               
               
                 atgtaactgg gtacctgtta tatcaaagaa cctcnattta ttaagtctcc tcatagccan    660 
               
               
                   
               
               
                 atccttatat ngccctctct gacctgantt aatananact tgaataatga atagttaatt    720 
               
               
                   
               
               
                 taggnttggg c                                                         731 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 47 
               
               
                 &lt;211&gt; LENGTH: 640 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (5) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (28) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (106) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (153) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (158) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (173) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (176) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (182) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (189) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (205) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (210) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (214) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (225) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (226) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (229) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (237) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (260) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (263) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (269) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (277) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (281) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (282) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (322) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (337) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (338) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (354) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (365) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (428) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (441) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (443) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (456) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (467) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (476) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (484) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (503) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (508) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (554) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (567) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (575) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (579) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (588) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (601) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (606) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (609) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (611) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (621) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (636) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 47 
               
               
                   
               
               
                 tgcgngccgg tttggccctt ctttgtanga cactttcatc cgccctgaaa tcttcccgat     60 
               
               
                   
               
               
                 cgttaataac tcctcaggtc cctgcctgca cagggttttt tcttantttg ttgcctaaca    120 
               
               
                   
               
               
                 gtacaccaaa tgtgacatcc tttcaccaat atngattnct tcataccaca tcntcnatgg    180 
               
               
                   
               
               
                 anacgactnc aacaattttt tgatnacccn aaanactggg ggctnnaana agtacantct    240 
               
               
                   
               
               
                 ggagcagcat ggacctgtcn gcnactaang gaacaanagt nntgaacatt tacacaacct    300 
               
               
                   
               
               
                 ttggtatgtc ttactgaaag anagaaacat gcttctnncc ctagaccacg aggncaaccg    360 
               
               
                   
               
               
                 caganattgc caatgccaag tccgagcggt tagatcaggt aatacattcc atggatgcat    420 
               
               
                   
               
               
                 tacatacntt gtccccgaaa nanaagatgc cctaanggct tcttcanact ggtccngaaa    480 
               
               
                   
               
               
                 acanctacac ctggtgcttg ganaacanac tctttggaag atcatctggc acaagttccc    540 
               
               
                   
               
               
                 cccagtgggt tttnccttgg cacctanctt accanatcna ttcggaancc attctttgcc    600 
               
               
                   
               
               
                 ntggcnttnt nttgggacca ntcttctcac aactgnaccc                          640 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 48 
               
               
                 &lt;211&gt; LENGTH: 257 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 48 
               
               
                   
               
               
                 actagtatat gaaaatgtaa atatcacttg tgtactcaaa caaaagttgg tcttaagctt     60 
               
               
                   
               
               
                 ccaccttgag cagccttgga aacctaacct gcctctttta gcataatcac attttctaaa    120 
               
               
                   
               
               
                 tgattttctt tgttcctgaa aaagtgattt gtattagttt tacatttgtt ttttggaaga    180 
               
               
                   
               
               
                 ttatatttgt atatgtatca tcataaaata tttaaataaa aagtatcttt agagtgaaaa    240 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaa                                                   257 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 49 
               
               
                 &lt;211&gt; LENGTH: 652 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (410) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (428) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (496) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (571) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (647) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 49 
               
               
                   
               
               
                 actagttcag atgagtggct gctgaagggg cccccttgtc attttcatta taacccaatt     60 
               
               
                   
               
               
                 tccacttatt tgaactctta agtcataaat gtataatgac ttatgaatta gcacagttaa    120 
               
               
                   
               
               
                 gttgacacta gaaactgccc atttctgtat tacactatca aataggaaac attggaaaga    180 
               
               
                   
               
               
                 tggggaaaaa aatcttattt taaaatggct tagaaagttt tcagattact ttgaaaattc    240 
               
               
                   
               
               
                 taaacttctt tctgtttcca aaacttgaaa atatgtagat ggactcatgc attaagactg    300 
               
               
                   
               
               
                 ttttcaaagc tttcctcaca tttttaaagt gtgattttcc ttttaatata catatttatt    360 
               
               
                   
               
               
                 ttctttaaag cagctatatc ccaacccatg actttggaga tatacctatn aaaccaatat    420 
               
               
                   
               
               
                 aacagcangg ttattgaagc agctttctca aatgttgctt cagatgtgca agttgcaaat    480 
               
               
                   
               
               
                 tttattgtat ttgtanaata caatttttgt tttaaactgt atttcaatct atttctccaa    540 
               
               
                   
               
               
                 gatgcttttc atatagagtg aaatatccca ngataactgc ttctgtgtcg tcgcatttga    600 
               
               
                   
               
               
                 cgcataactg cacaaatgaa cagtgtatac ctcttggttg tgcattnacc cc            652 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 50 
               
               
                 &lt;211&gt; LENGTH: 650 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (237) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (270) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (311) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (443) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (454) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (488) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (520) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (535) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (539) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (556) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (567) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (594) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (603) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (634) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 50 
               
               
                   
               
               
                 ttgcgctttg atttttttag ggcttgtgcc ctgtttcact tatagggtct agaatgcttg     60 
               
               
                   
               
               
                 tgttgagtaa aaaggagatg cccaatattc aaagctgcta aatgttctct ttgccataaa    120 
               
               
                   
               
               
                 gactccgtgt aactgtgtga acacttggga tttttctcct ctgtcccgag gtcgtcgtct    180 
               
               
                   
               
               
                 gctttctttt ttgggttctt tctagaagat tgagaaatgc atatgacagg ctgagancac    240 
               
               
                   
               
               
                 ctccccaaac acacaagctc tcagccacan gcagcttctc cacagcccca gcttcgcaca    300 
               
               
                   
               
               
                 ggctcctgga nggctgcctg ggggaggcag acatgggagt gccaaggtgg ccagatggtt    360 
               
               
                   
               
               
                 ccaggactac aatgtcttta tttttaactg tttgccactg ctgccctcac ccctgcccgg    420 
               
               
                   
               
               
                 ctctggagta ccgtctgccc canacaagtg ggantgaaat gggggtgggg gggaacactg    480 
               
               
                   
               
               
                 attcccantt agggggtgcc taactgaaca gtagggatan aaggtgtgaa cctgngaant    540 
               
               
                   
               
               
                 gcttttataa attatnttcc ttgttanatt tattttttaa tttaatctct gttnaactgc    600 
               
               
                   
               
               
                 ccngggaaaa ggggaaaaaa aaaaaaaaat tctntttaaa cacatgaaca               650 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 51 
               
               
                 &lt;211&gt; LENGTH: 545 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (66) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (159) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (195) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (205) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (214) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (243) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (278) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (298) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (306) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (337) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (366) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (375) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (382) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (405) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (446) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (477) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (492) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (495) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (503) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (507) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (508) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (521) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (537) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 51 
               
               
                   
               
               
                 tggcgtgcaa ccagggtagc tgaagtttgg gtctgggact ggagattggc cattaggcct     60 
               
               
                   
               
               
                 cctganattc cagctccctt ccaccaagcc cagtcttgct acgtggcaca gggcaaacct    120 
               
               
                   
               
               
                 gactcccttt gggcctcagt ttcccctccc cttcatgana tgaaaagaat actacttttt    180 
               
               
                   
               
               
                 cttgttggtc taacnttgct ggacncaaag tgtngtcatt attgttgtat tgggtgatgt    240 
               
               
                   
               
               
                 gtncaaaact gcagaagctc actgcctatg agaggaanta agagagatag tggatganag    300 
               
               
                   
               
               
                 ggacanaagg agtcattatt tggtatagat ccacccntcc caacctttct ctcctcagtc    360 
               
               
                   
               
               
                 cctgcncctc atgtntctgg tntggtgagt cctttgtgcc accanccatc atgctttgca    420 
               
               
                   
               
               
                 ttgctgccat cctgggaagg gggtgnatcg tctcacaact tgttgtcatc gtttganatg    480 
               
               
                   
               
               
                 catgctttct tnatnaaaca aanaaannaa tgtttgacag ngtttaaaat aaaaaanaaa    540 
               
               
                   
               
               
                 caaaa                                                                545 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 52 
               
               
                 &lt;211&gt; LENGTH: 678 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (98) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (119) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (121) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (131) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (136) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (139) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (140) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (142) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (143) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (163) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (168) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (172) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (176) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (184) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (189) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (190) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (191) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (200) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (201) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (205) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (207) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (221) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (223) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (229) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (230) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (237) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (240) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (241) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (255) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (264) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (266) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (267) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (276) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (280) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (288) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (289) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (291) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (297) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (301) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (306) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (308) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (314) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (315) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (326) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (332) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (335) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (337) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (339) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (341) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (343) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (344) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (345) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (347) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (350) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (355) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (356) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (358) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (362) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (363) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (372) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (379) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (395) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (397) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (398) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (400) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (403) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (412) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (414) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (421) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (423) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (431) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (435) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (438) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (439 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (457) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (463) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (467) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (471) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (474) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (480) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (483) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (484) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (487) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (490) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (491) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (492) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (493) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (499) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (500) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (504) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (508) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (518) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (536) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (538) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (549) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (551) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (552) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (554) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (556) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (557) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (562) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (563) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (567) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (571) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (572) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (576) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (579) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (590) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (592) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (595) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (598) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (606) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (609) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (613) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (620) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (622) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (624) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (626) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (631) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (634) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (638) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (641) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (647) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (654) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (660) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (661) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (664) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 52 
               
               
                   
               
               
                 actagtagaa gaactttgcc gcttttgtgc ctctcacagg cgcctaaagt cattgccatg     60 
               
               
                   
               
               
                 ggaggaagac gatttggggg gggagggggg gggggcangg tccgtggggc tttccctant    120 
               
               
                   
               
               
                 ntatctccat ntccantgnn cnntgtcgcc tcttccctcg tcncattnga anttantccc    180 
               
               
                   
               
               
                 tggnccccnn nccctctccn ncctncncct cccccctccg ncncctccnn ctttttntan    240 
               
               
                   
               
               
                 ncttccccat ctccntcccc cctnanngtc ccaacnccgn cagcaatnnc ncacttnctc    300 
               
               
                   
               
               
                 nctccncncc tccnnccgtt cttctnttct cnacntntnc ncnnntnccn tgccnntnaa    360 
               
               
                   
               
               
                 annctctccc cnctgcaanc gattctctcc ctccncnnan ctntccactc cntncttctc    420 
               
               
                   
               
               
                 ncncgctcct nttcntcnnc ccacctctcn ccttcgnccc cantacnctc nccncccttn    480 
               
               
                   
               
               
                 cgnntcnttn nnntcctcnn accncccncc tcccttcncc cctcttctcc ccggtntntc    540 
               
               
                   
               
               
                 tctctcccnc nncncnncct cnncccntcc nngcgnccnt ttccgccccn cnccnccntt    600 
               
               
                   
               
               
                 ccttcntcnc cantccatcn cntntnccat nctncctncc nctcacnccc gctncccccn    660 
               
               
                   
               
               
                 ntctctttca cacngtcc                                                  678 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 53 
               
               
                 &lt;211&gt; LENGTH: 502 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (139) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (146) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (215) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (217) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (257) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (263) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (289) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (386) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (420) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (452) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (457) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (461) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (466) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (482) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (486) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 53 
               
               
                   
               
               
                 tgaagatcct ggtgtcgcca tgggccgccg ccccgcccgt tgttaccggt attgtaagaa     60 
               
               
                   
               
               
                 caagccgtac ccaaagtctc gcttctgccg aggtgtccct gatgccaaaa ttcgcatttt    120 
               
               
                   
               
               
                 tgacctgggg cggaaaaang caaaantgga tgagtctccg ctttgtggcc acatggtgtc    180 
               
               
                   
               
               
                 agatcaatat gagcagctgt cctctgaagc cctgnangct gcccgaattt gtgccaataa    240 
               
               
                   
               
               
                 gtacatggta aaaagtngtg gcnaagatgc ttccatatcc gggtgcggnt ccaccccttc    300 
               
               
                   
               
               
                 cacgtcatcc gcatcaacaa gatgttgtcc tgtgctgggg ctgacaggct cccaacaggc    360 
               
               
                   
               
               
                 atgcgaagtg cctttggaaa acccanggca ctgtggccag ggttcacatt gggccaattn    420 
               
               
                   
               
               
                 atcatgttca tccgcaccaa ctgcagaaca angaacntgt naattnaagc cctgcccagg    480 
               
               
                   
               
               
                 gncaanttca aatttcccgg cc                                             502 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 54 
               
               
                 &lt;211&gt; LENGTH: 494 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (431) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (442) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (445) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 54 
               
               
                   
               
               
                 actagtccaa gaaaaatatg cttaatgtat attacaaagg ctttgtatat gttaacctgt     60 
               
               
                   
               
               
                 tttaatgcca aaagtttgct ttgtccacaa tttccttaag acctcttcag aaagggattt    120 
               
               
                   
               
               
                 gtttgcctta atgaatactg ttgggaaaaa acacagtata atgagtgaaa agggcagaag    180 
               
               
                   
               
               
                 caagaaattt ctacatctta gcgactccaa gaagaatgag tatccacatt tagatggcac    240 
               
               
                   
               
               
                 attatgagga ctttaatctt tccttaaaca caataatgtt ttcttttttc ttttattcac    300 
               
               
                   
               
               
                 atgatttcta agtatatttt tcatgcagga cagtttttca accttgatgt acagtgactg    360 
               
               
                   
               
               
                 tgttaaattt ttctttcagt ggcaacctct ataatcttta aaatatggtg agcatcttgt    420 
               
               
                   
               
               
                 ctgttttgaa ngggatatga cnatnaatct atcagatggg aaatcctgtt tccaagttag    480 
               
               
                   
               
               
                 aaaaaaaaaa aaaa                                                      494 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 55 
               
               
                 &lt;211&gt; LENGTH: 606 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (375) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (395) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (511) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (542) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (559) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (569) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (578) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (581) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 55 
               
               
                   
               
               
                 actagtaaaa agcagcattg ccaaataatc cctaattttc cactaaaaat ataatgaaat     60 
               
               
                   
               
               
                 gatgttaagc tttttgaaaa gtttaggtta aacctactgt tgttagatta atgtatttgt    120 
               
               
                   
               
               
                 tgcttccctt tatctggaat gtggcattag cttttttatt ttaaccctct ttaattctta    180 
               
               
                   
               
               
                 ttcaattcca tgacttaagg ttggagagct aaacactggg atttttggat aacagactga    240 
               
               
                   
               
               
                 cagttttgca taattataat cggcattgta catagaaagg atatggctac cttttgttaa    300 
               
               
                   
               
               
                 atctgcactt tctaaatatc aaaaaaggga aatgaagtat aaatcaattt ttgtataatc    360 
               
               
                   
               
               
                 tgtttgaaac atgantttta tttgcttaat attanggctt tgcccttttc tgttagtctc    420 
               
               
                   
               
               
                 ttgggatcct gtgtaaaact gttctcatta aacaccaaac agttaagtcc attctctggt    480 
               
               
                   
               
               
                 actagctaca aattccgttt catattctac ntaacaattt aaattaactg aaatatttct    540 
               
               
                   
               
               
                 anatggtcta cttctgtcnt ataaaaacna aacttgantt nccaaaaaaa aaaaaaaaaa    600 
               
               
                   
               
               
                 aaaaaa                                                               606 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 56 
               
               
                 &lt;211&gt; LENGTH: 183 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 56 
               
               
                   
               
               
                 actagtatat ttaaacttac aggcttattt gtaatgtaaa ccaccatttt aatgtactgt     60 
               
               
                   
               
               
                 aattaacatg gttataatac gtacaatcct tccctcatcc catcacacaa ctttttttgt    120 
               
               
                   
               
               
                 gtgtgataaa ctgattttgg tttgcaataa aaccttgaaa aataaaaaaa aaaaaaaaaa    180 
               
               
                   
               
               
                 aaa                                                                  183 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 57 
               
               
                 &lt;211&gt; LENGTH: 622 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (358) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (368) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (412) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (414) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (425) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (430) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (453) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (455) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (469) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (475) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (495) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (499) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (529) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (540) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (564) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (575) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (590) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 57 
               
               
                   
               
               
                 actagtcact actgtcttct ccttgtagct aatcaatcaa tattcttccc ttgcctgtgg     60 
               
               
                   
               
               
                 gcagtggaga gtgctgctgg gtgtacgctg cacctgccca ctgagttggg gaaagaggat    120 
               
               
                   
               
               
                 aatcagtgag cactgttctg ctcagagctc ctgatctacc ccacccccta ggatccagga    180 
               
               
                   
               
               
                 ctgggtcaaa gctgcatgaa accaggccct ggcagcaacc tgggaatggc tggaggtggg    240 
               
               
                   
               
               
                 agagaacctg acttctcttt ccctctccct cctccaacat tactggaact ctatcctgtt    300 
               
               
                   
               
               
                 agggatcttc tgagcttgtt tccctgctgg gtgggacaga agacaaagga gaagggangg    360 
               
               
                   
               
               
                 tctacaanaa gcagcccttc tttgtcctct ggggttaatg agcttgacct ananttcatg    420 
               
               
                   
               
               
                 gaganaccan aagcctctga tttttaattt ccntnaaatg tttgaagtnt atatntacat    480 
               
               
                   
               
               
                 atatatattt ctttnaatnt ttgagtcttt gatatgtctt aaaatccant ccctctgccn    540 
               
               
                   
               
               
                 gaaacctgaa ttaaaaccat gaanaaaaat gtttncctta aagatgttan taattaattg    600 
               
               
                   
               
               
                 aaacttgaaa aaaaaaaaaa aa                                             622 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 58 
               
               
                 &lt;211&gt; LENGTH: 433 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 58 
               
               
                   
               
               
                 gaacaaattc tgattggtta tgtaccgtca aaagacttga agaaatttca tgattttgca     60 
               
               
                   
               
               
                 gtgtggaagc gttgaaaatt gaaagttact gcttttccac ttgctcatat agtaaaggga    120 
               
               
                   
               
               
                 tcctttcagc tgccagtgtt gaataatgta tcatccagag tgatgttatc tgtgacagtc    180 
               
               
                   
               
               
                 accagcttta agctgaacca ttttatgaat accaaataaa tagacctctt gtactgaaaa    240 
               
               
                   
               
               
                 catatttgtg actttaatcg tgctgcttgg atagaaatat ttttactggt tcttctgaat    300 
               
               
                   
               
               
                 tgacagtaaa cctgtccatt atgaatggcc tactgttcta ttatttgttt tgacttgaat    360 
               
               
                   
               
               
                 ttatccacca aagacttcat ttgtgtatca tcaataaagt tgtatgtttc aactgaaaaa    420 
               
               
                   
               
               
                 aaaaaaaaaa aaa                                                       433 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 59 
               
               
                 &lt;211&gt; LENGTH: 649 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (22) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (190) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (217) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (430) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (433) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (484) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (544) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (550) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (577) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (583) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (594) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 59 
               
               
                   
               
               
                 actagttatt atctgacttt cnggttataa tcattctaat gagtgtgaag tagcctctgg     60 
               
               
                   
               
               
                 tgtcatttgg atttgcattt ctctgatgag tgatgctatc aagcaccttt gctggtgctg    120 
               
               
                   
               
               
                 ttggccatat gtgtatgttc cctggagaag tgtctgtgct gagccttggc ccacttttta    180 
               
               
                   
               
               
                 attaggcgtn tgtcttttta ttactgagtt gtaaganttc tttatatatt ctggattcta    240 
               
               
                   
               
               
                 gacccttatc agatacatgg tttgcaaata ttttctccca ttctgtgggt tgtgttttca    300 
               
               
                   
               
               
                 ctttatcgat aatgtcctta gacatataat aaatttgtat tttaaaagtg acttgatttg    360 
               
               
                   
               
               
                 ggctgtgcaa ggtgggctca cgcttgtaat cccagcactt tgggagactg aggtgggtgg    420 
               
               
                   
               
               
                 atcatatgan gangctagga gttcgaggtc agcctggcca gcatagcgaa aacttgtctc    480 
               
               
                   
               
               
                 tacnaaaaat acaaaaatta gtcaggcatg gtggtgcacg tctgtaatac cagcttctca    540 
               
               
                   
               
               
                 ggangctgan gcacaaggat cacttgaacc ccagaangaa gangttgcag tganctgaag    600 
               
               
                   
               
               
                 atcatgccag ggcaacaaaa atgagaactt gtttaaaaaa aaaaaaaaa                649 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 60 
               
               
                 &lt;211&gt; LENGTH: 423 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (209) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (222) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (277) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (389) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (398) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 60 
               
               
                   
               
               
                 actagttcag gccttccagt tcactgacaa acatggggaa gtgtgcccag ctggctggaa     60 
               
               
                   
               
               
                 acctggcagt gataccatca agcctgatgt ccaaaagagc aaagaatatt tctccaagca    120 
               
               
                   
               
               
                 gaagtgagcg ctgggctgtt ttagtgccag gctgcggtgg gcagccatga gaacaaaacc    180 
               
               
                   
               
               
                 tcttctgtat tttttttttc cattagtana acacaagact cngattcagc cgaattgtgg    240 
               
               
                   
               
               
                 tgtcttacaa ggcagggctt tcctacaggg ggtgganaaa acagcctttc ttcctttggt    300 
               
               
                   
               
               
                 aggaatggcc tgagttggcg ttgtgggcag gctactggtt tgtatgatgt attagtagag    360 
               
               
                   
               
               
                 caacccatta atcttttgta gtttgtatna aacttganct gagaccttaa acaaaaaaaa    420 
               
               
                   
               
               
                 aaa                                                                  423 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 61 
               
               
                 &lt;211&gt; LENGTH: 423 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (195) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (285) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (295) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (329) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (335) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (340) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (347) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (367) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (382) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (383) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (391) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (396) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (418) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 61 
               
               
                   
               
               
                 cgggactgga atgtaaagtg aagttcggag ctctgagcac gggctcttcc cgccgggtcc     60 
               
               
                   
               
               
                 tccctcccca gaccccagag ggagaggccc accccgccca gccccgcccc agcccctgct    120 
               
               
                   
               
               
                 caggtctgag tatggctggg agtcgggggc cacaggcctc tagctgtgct gctcaagaag    180 
               
               
                   
               
               
                 actggatcag ggtanctaca agtggccggg ccttgccttt gggattctac cctgttccta    240 
               
               
                   
               
               
                 atttggtgtt ggggtgcggg gtccctggcc cccttttcca cactncctcc ctccngacag    300 
               
               
                   
               
               
                 caacctccct tggggcaatt gggcctggnt ctccncccgn tgttgcnacc ctttgttggt    360 
               
               
                   
               
               
                 ttaaggnctt taaaaatgtt annttttccc ntgccngggt taaaaaagga aaaaactnaa    420 
               
               
                   
               
               
                 aaa                                                                  423 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 62 
               
               
                 &lt;211&gt; LENGTH: 683 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (218) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (291) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (305) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (411) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (416) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (441) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (443) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (453) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (522) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (523) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (536) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (542) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (547) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (566) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (588) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (592) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (595) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (603) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (621) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (628) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (630) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (632) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (644) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (645) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (648) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (655) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (660) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (672) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (674) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (676) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (677) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (683) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 62 
               
               
                   
               
               
                 gctggagagg ggtacggact ttcttggagt tgtcccaggt tggaatgaga ctgaactcaa     60 
               
               
                   
               
               
                 gaagagaccc taagagactg gggaatggtt cctgccttca ggaaagtgaa agacgcttag    120 
               
               
                   
               
               
                 gctgtcaaca cttaaaggaa gtccccttga agcccagagt ggacagacta gacccattga    180 
               
               
                   
               
               
                 tggggccact ggccatggtc cgtggacaag acattccngt gggccatggc acaccggggg    240 
               
               
                   
               
               
                 ggatcaaaat gtgtacttgt ggggtctcgc cccttgccaa aaccaaacca ntcccactcc    300 
               
               
                   
               
               
                 tgtcnttgga ctttcttccc attccctcct ccccaaatgc acttcccctc ctccctctgc    360 
               
               
                   
               
               
                 ccctcctgtg tttttggaat tctgtttccc tcaaaattgt taatttttta nttttngacc    420 
               
               
                   
               
               
                 atgaacttat gtttggggtc nangttcccc ttnccaatgc atactaatat attaatggtt    480 
               
               
                   
               
               
                 atttattttt gaaatatttt ttaatgaact tggaaaaaat tnntggaatt tccttncttc    540 
               
               
                   
               
               
                 cnttttnttt ggggggggtg gggggntggg ttaaaatttt tttggaancc cnatnggaaa    600 
               
               
                   
               
               
                 ttnttacttg gggcccccct naaaaaantn anttccaatt cttnnatngc ccctnttccn    660 
               
               
                   
               
               
                 ctaaaaaaaa ananannaaa aan                                            683 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 63 
               
               
                 &lt;211&gt; LENGTH: 731 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (236) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (249) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (263) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (288) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (312) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (317) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (323) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (326) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (337) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (352) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (362) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (370) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (376) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (400) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (411) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (414) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (434) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (436) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (446) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (457) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (473) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (486) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (497) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (498) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (502) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (512) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (531) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (546) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (554) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (563) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (565) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (566) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (588) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (597) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (608) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (611) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (613) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (615) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (627) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (632) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (640) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (641) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (644) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (654) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (660) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (663) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (665) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (671) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (678) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (692) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (697) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (698) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (699) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (704) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (705) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (712) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (714) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (717) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (718) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (719) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (723) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (725) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (730) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (731) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 63 
               
               
                   
               
               
                 actagtcata aagggtgtgc gcgtcttcga cgtggcggtc ttggcgccac tgctgcgaga     60 
               
               
                   
               
               
                 cccggccctg gacctcaagg tcatccactt ggtgcgtgat ccccgcgcgg tggcgagttc    120 
               
               
                   
               
               
                 acggatccgc tcgcgccacg gcctcatccg tgagagccta caggtggtgc gcagccgaga    180 
               
               
                   
               
               
                 ccgcgagctc accgcatgcc cttcttggag gccgcgggcc acaagcttgg cgcccanaaa    240 
               
               
                   
               
               
                 gaaggcgtng ggggcccgca aantaccacg ctctgggcgc tatggaangt cctcttgcaa    300 
               
               
                   
               
               
                 taatattggt tnaaaanctg canaanagcc cctgcanccc cctgaactgg gntgcagggc    360 
               
               
                   
               
               
                 cncttacctn gtttggntgc ggttacaaag aacctgtttn ggaaaaccct nccnaaaacc    420 
               
               
                   
               
               
                 ttccgggaaa attntncaaa tttttnttgg ggaattnttg ggtaaacccc ccnaaaatgg    480 
               
               
                   
               
               
                 gaaacntttt tgccctnnaa antaaaccat tnggttccgg gggccccccc ncaaaaccct    540 
               
               
                   
               
               
                 tttttntttt tttntgcccc cantnncccc ccggggcccc tttttttngg ggaaaanccc    600 
               
               
                   
               
               
                 cccccctncc nanantttta aaagggnggg anaatttttn nttncccccc gggncccccn    660 
               
               
                   
               
               
                 ggngntaaaa nggtttcncc cccccgaggg gnggggnnnc ctcnnaaacc cntntcnnna    720 
               
               
                   
               
               
                 ccncnttttn n                                                         731 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 64 
               
               
                 &lt;211&gt; LENGTH: 313 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (240) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 64 
               
               
                   
               
               
                 actagttgtg caaaccacga ctgaagaaag acgaaaagtg ggaaataact tgcaacgtct     60 
               
               
                   
               
               
                 gttagagatg gttgctacac atgttgggtc tgtagagaaa catcttgagg agcagattgc    120 
               
               
                   
               
               
                 taaagttgat agagaatatg aagaatgcat gtcagaagat ctctcggaaa atattaaaga    180 
               
               
                   
               
               
                 gattagagat aagtatgaga agaaagctac tctaattaag tcttctgaag aatgaagatn    240 
               
               
                   
               
               
                 aaatgttgat catgtatata tatccatagt gaataaaatt gtctcagtaa agttgtaaaa    300 
               
               
                   
               
               
                 aaaaaaaaaa aaa                                                       313 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 65 
               
               
                 &lt;211&gt; LENGTH: 420 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (400) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (402) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (403) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (404) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (405) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (406) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (409) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (411) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (412) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (414) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (415) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (416) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 65 
               
               
                   
               
               
                 actagttccc tggcaggcaa gggcttccaa ctgaggcagt gcatgtgtgg cagagagagg     60 
               
               
                   
               
               
                 caggaagctg gcagtggcag cttctgtgtc tagggagggg tgtggctccc tccttccctg    120 
               
               
                   
               
               
                 tctgggaggt tggagggaag aatctaggcc ttagcttgcc ctcctgccac ccttcccctt    180 
               
               
                   
               
               
                 gtagatactg ccttaacact ccctcctctc tcagctgtgg ctgccaccca agccaggttt    240 
               
               
                   
               
               
                 ctccgtgctc actaatttat ttccaggaaa ggtgtgtgga agacatgagc cgtgtataat    300 
               
               
                   
               
               
                 atttgtttta acattttcat tgcaagtatt gaccatcatc cttggttgtg tatcgttgta    360 
               
               
                   
               
               
                 acacaaatta atgatattaa aaagcatcca aacaaagccn annnnnaana nnannngaaa    420 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 66 
               
               
                 &lt;211&gt; LENGTH: 676 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (328) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (454) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (505) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (555) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (586) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (612) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (636) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (641) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 66 
               
               
                   
               
               
                 actagtttcc tatgatcatt aaactcattc tcagggttaa gaaaggaatg taaatttctg     60 
               
               
                   
               
               
                 cctcaatttg tacttcatca ataagttttt gaagagtgca gatttttagt caggtcttaa    120 
               
               
                   
               
               
                 aaataaactc acaaatctgg atgcatttct aaattctgca aatgtttcct ggggtgactt    180 
               
               
                   
               
               
                 aacaaggaat aatcccacaa tatacctagc tacctaatac atggagctgg ggctcaaccc    240 
               
               
                   
               
               
                 actgttttta aggatttgcg cttacttgtg gctgaggaaa aataagtagt tccgagggaa    300 
               
               
                   
               
               
                 gtagttttta aatgtgagct tatagatngg aaacagaata tcaacttaat tatggaaatt    360 
               
               
                   
               
               
                 gttagaaacc tgttctcttg ttatctgaat cttgattgca attactattg tactggatag    420 
               
               
                   
               
               
                 actccagccc attgcaaagt ctcagatatc ttanctgtgt agttgaattc cttggaaatt    480 
               
               
                   
               
               
                 ctttttaaga aaaaattgga gtttnaaaga aataaacccc tttgttaaat gaagcttggc    540 
               
               
                   
               
               
                 tttttggtga aaaanaatca tcccgcaggg cttattgttt aaaaanggaa ttttaagcct    600 
               
               
                   
               
               
                 ccctggaaaa anttgttaat taaatgggga aaatgntggg naaaaattat ccgttagggt    660 
               
               
                   
               
               
                 ttaaagggaa aactta                                                    676 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 67 
               
               
                 &lt;211&gt; LENGTH: 620 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (419) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (493) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (519) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (568) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (605) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (610) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 67 
               
               
                   
               
               
                 caccattaaa gctgcttacc aagaacttcc ccagcatttt gacttccttg tttgatagct     60 
               
               
                   
               
               
                 gaattgtgag caggtgatag aagagccttt ctagttgaac atacagataa tttgctgaat    120 
               
               
                   
               
               
                 acattccatt taatgaaggg gttacatctg ttacgaagct actaagaagg agcaagagca    180 
               
               
                   
               
               
                 taggggaaaa aaatctgatc agaacgcatc aaactcacat gtgccccctc tactacaaac    240 
               
               
                   
               
               
                 agattgtagt gctgtggtgg tttattccgt tgtgcagaac ttgcaagctg agtcactaaa    300 
               
               
                   
               
               
                 cccaaagaga ggaaattata ggttagttaa acattgtaat cccaggaact aagtttaatt    360 
               
               
                   
               
               
                 cacttttgaa gtgttttgtt ttttattttt ggtttgtctg atttactttg ggggaaaang    420 
               
               
                   
               
               
                 ctaaaaaaaa agggatatca atctctaatt cagtgcccac taaaagttgt ccctaaaaag    480 
               
               
                   
               
               
                 tctttactgg aanttatggg actttttaag ctccaggtnt tttggtcctc caaattaacc    540 
               
               
                   
               
               
                 ttgcatgggc cccttaaaat tgttgaangg cattcctgcc tctaagtttg gggaaaattc    600 
               
               
                   
               
               
                 ccccnttttn aaaatttgga                                                620 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 68 
               
               
                 &lt;211&gt; LENGTH: 551 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (286) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (464) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (480) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (501) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (502) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (518) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (528) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (533) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (536) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (537) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (538) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (539) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (540) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (541) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (543) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (544) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (545) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (547) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (548) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (549) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 68 
               
               
                   
               
               
                 actagtagct ggtacataat cactgaggag ctatttctta acatgctttt atagaccatg     60 
               
               
                   
               
               
                 ctaatgctag accagtattt aagggctaat ctcacacctc cttagctgta agagtctggc    120 
               
               
                   
               
               
                 ttagaacaga cctctctgtg caataacttg tggccactgg aaatccctgg gccggcattt    180 
               
               
                   
               
               
                 gtattggggt tgcaatgact cccaagggcc aaaagagtta aaggcacgac tgggatttct    240 
               
               
                   
               
               
                 tctgagactg tggtgaaact ccttccaagg ctgagggggt cagtangtgc tctgggaggg    300 
               
               
                   
               
               
                 actcggcacc actttgatat tcaacaagcc acttgaagcc caattataaa attgttattt    360 
               
               
                   
               
               
                 tacagctgat ggaactcaat ttgaaccttc aaaactttgt tagtttatcc tattatattg    420 
               
               
                   
               
               
                 ttaaacctaa ttacatttgt ctagcattgg atttggttcc tgtngcatat gtttttttcn    480 
               
               
                   
               
               
                 cctatgtgct cccctccccc nnatcttaat ttaaaccnca attttgcnat tcnccnnnnn    540 
               
               
                   
               
               
                 nannnannna a                                                         551 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 69 
               
               
                 &lt;211&gt; LENGTH: 396 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (255) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (310) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (322) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (381) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 69 
               
               
                   
               
               
                 cagaaatgga aagcagagtt ttcatttctg tttataaacg tctccaaaca aaaatggaaa     60 
               
               
                   
               
               
                 gcagagtttt cattaaatcc ttttaccttt tttttttctt ggtaatcccc tcaaataaca    120 
               
               
                   
               
               
                 gtatgtggga tattgaatgt taaagggata tttttttcta ttatttttat aattgtacaa    180 
               
               
                   
               
               
                 aattaagcaa atgttaaaag ttttatatgc tttattaatg ttttcaaaag gtatnataca    240 
               
               
                   
               
               
                 tgtgatacat tttttaagct tcagttgctt gtcttctggt actttctgtt atgggctttt    300 
               
               
                   
               
               
                 ggggagccan aaaccaatct acnatctctt tttgtttgcc aggacatgca ataaaattta    360 
               
               
                   
               
               
                 aaaaataaat aaaaactatt nagaaattga aaaaaa                              396 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 70 
               
               
                 &lt;211&gt; LENGTH: 536 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (388) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (446) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (455) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 70 
               
               
                   
               
               
                 actagtgcaa aagcaaatat aaacatcgaa aaggcgttcc tcacgttagc tgaagatatc     60 
               
               
                   
               
               
                 cttcgaaaga cccctgtaaa agagcccaac agtgaaaatg tagatatcag cagtggagga    120 
               
               
                   
               
               
                 ggcgtgacag gctggaagag caaatgctgc tgagcattct cctgttccat cagttgccat    180 
               
               
                   
               
               
                 ccactacccc gttttctctt cttgctgcaa aataaaccac tctgtccatt tttaactcta    240 
               
               
                   
               
               
                 aacagatatt tttgtttctc atcttaacta tccaagccac ctattttatt tgttctttca    300 
               
               
                   
               
               
                 tctgtgactg cttgctgact ttatcataat tttcttcaaa caaaaaaatg tatagaaaaa    360 
               
               
                   
               
               
                 tcatgtctgt gacttcattt ttaaatgnta cttgctcagc tcaactgcat ttcagttgtt    420 
               
               
                   
               
               
                 ttatagtcca gttcttatca acattnaaac ctatngcaat catttcaaat ctattctgca    480 
               
               
                   
               
               
                 aattgtataa gaataaaagt tagaatttaa caattaaaaa aaaaaaaaaa aaaaaa        536 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 71 
               
               
                 &lt;211&gt; LENGTH: 865 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (22) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (35) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (39) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (56) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (131) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (138) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (146) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (183) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (194) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (197) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (238) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (269) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (277) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (282) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (297) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (316) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (331) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (336) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (340) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (341) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (346) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (349) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (370) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (376) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (381) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (382) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (392) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (396) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (397) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (401) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (433) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (444) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (445) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (454) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (455) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (469) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (472) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (477) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (480) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (482) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (489) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (497) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (499) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (511) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (522) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (526) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (527) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (545) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (553) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (556) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (567) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (574) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (580) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (610) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (613) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (634) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (638) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (639) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (663) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (672) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (689) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (693) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (694) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (701) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (704) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (713) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (723) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (729) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (732) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (743) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (744) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (749) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (761) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (765) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (767) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (769) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (772) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (774) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (780) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (783) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (788) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (792) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (803) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (810) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (824) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (840) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (848) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 71 
               
               
                   
               
               
                 gacaaagcgt taggagaaga anagaggcag ggaanactnc ccaggcacga tggccncctt     60 
               
               
                   
               
               
                 cccaccagca accagcgccc cccaccagcc cccaggcccg gacgacgaag actccatcct    120 
               
               
                   
               
               
                 ggattaatct nacctctntc gcctgnccca ttcctacctc ggaggtggag gccggaaagg    180 
               
               
                   
               
               
                 tcncaccaag aganaanctg ctgccaacac caaccgcccc agccctggcg ggcacganag    240 
               
               
                   
               
               
                 gaaactggtg accaatctgc agaattctna gaggaanaag cnaggggccc cgcgctnaga    300 
               
               
                   
               
               
                 cagagctgga tatgangcca gaccatggac nctacncccn ncaatncana cgggactgcg    360 
               
               
                   
               
               
                 gaagatggan gacccncgac nngatcaggc cngctnncca nccccccacc cctatgaatt    420 
               
               
                   
               
               
                 attcccgctg aangaatctc tgannggctt ccannaaagc gcctccccnc cnaacgnaan    480 
               
               
                   
               
               
                 tncaacatng ggattanang ctgggaactg naaggggcaa ancctnnaat atccccagaa    540 
               
               
                   
               
               
                 acaanctctc ccnaanaaac tggggcncct catnggtggn accaactatt aactaaaccg    600 
               
               
                   
               
               
                 cacgccaagn aantataaaa ggggggcccc tccncggnng accccctttt gtcccttaat    660 
               
               
                   
               
               
                 ganggttatc cnccttgcgt accatggtnc ccnnttctgt ntgnatgttt ccnctcccct    720 
               
               
                   
               
               
                 ccncctatnt cnagccgaac tcnnatttnc ccgggggtgc natcnantng tncncctttn    780 
               
               
                   
               
               
                 ttngttgncc cngccctttc cgncggaacn cgtttccccg ttantaacgg cacccggggn    840 
               
               
                   
               
               
                 aagggtgntt ggccccctcc ctccc                                          865 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 72 
               
               
                 &lt;211&gt; LENGTH: 560 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (83) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (173) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (183) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (186) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (209) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (211) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (215) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (255) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (321) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (322) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (323) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (335) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (344) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (357) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (361) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (368) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (394) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (412) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (415) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (442) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (455) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (469) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (472) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (475) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (487) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (513) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (522) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (528) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (531) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (534) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (546) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 72 
               
               
                   
               
               
                 cctggacttg tcttggttcc agaacctgac gacccggcga cggcgacgtc tcttttgact     60 
               
               
                   
               
               
                 aaaagacagt gtccagtgct ccngcctagg agtctacggg gaccgcctcc cgcgccgcca    120 
               
               
                   
               
               
                 ccatgcccaa cttctctggc aactggaaaa tcatccgatc ggaaaacttc gangaattgc    180 
               
               
                   
               
               
                 tcnaantgct gggggtgaat gtgatgctna ngaanattgc tgtggctgca gcgtccaagc    240 
               
               
                   
               
               
                 cagcagtgga gatcnaacag gagggagaca ctttctacat caaaacctcc accaccgtgc    300 
               
               
                   
               
               
                 gcaccacaaa gattaacttc nnngttgggg aggantttga ggancaaact gtggatngga    360 
               
               
                   
               
               
                 ngcctgtnaa aacctggtga aatgggagaa tganaataaa atggtctgtg ancanaaact    420 
               
               
                   
               
               
                 cctgaaagga gaaggccccc anaactcctg gaccngaaaa actgacccnc cnatngggga    480 
               
               
                   
               
               
                 actgatnctt gaaccctgaa cgggcgggat ganccttttt tnttgccncc naangggttc    540 
               
               
                   
               
               
                 tttccntttc cccaaaaaaa                                                560 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 73 
               
               
                 &lt;211&gt; LENGTH: 379 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (8) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (17) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (18) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (21) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (26) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (29) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (30) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (32) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (53) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (56) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (67) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (71) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (81) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (102) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (104) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (111) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (112) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (114) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (119) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (122) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (124) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (125) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (134) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (144) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (146) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (189) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (190) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (214) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (215) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (219) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (222) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (235) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (237) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (246) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (280) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (288) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (302) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (310) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (313) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (319) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (322) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (343) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (353) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (354) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 73 
               
               
                   
               
               
                 ctggggancc ggcggtnngc nccatntcnn gncgcgaagg tggcaataaa aanccnctga     60 
               
               
                   
               
               
                 aaccgcncaa naaacatgcc naagatatgg acgaggaaga tngngctttc nngnacaanc    120 
               
               
                   
               
               
                 gnanngagga acanaacaaa ctcnangagc tctcaagcta atgccgcggg gaaggggccc    180 
               
               
                   
               
               
                 ttggccacnn gtggaattaa gaaatctggc aaanngtann tgttccttgt gcctnangag    240 
               
               
                   
               
               
                 ataagngacc ctttatttca tctgtattta aacctctctn ttccctgnca taacttcttt    300 
               
               
                   
               
               
                 tnccacgtan agntggaant anttgttgtc ttggactgtt gtncatttta gannaaactt    360 
               
               
                   
               
               
                 ttgttcaaaa aaaaaataa                                                 379 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 74 
               
               
                 &lt;211&gt; LENGTH: 437 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (145) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (355) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 74 
               
               
                   
               
               
                 actagttcag actgccacgc caaccccaga aaatacccca catgccagaa aagtgaagtc     60 
               
               
                   
               
               
                 ctaggtgttt ccatctatgt ttcaatctgt ccatctacca ggcctcgcga taaaaacaaa    120 
               
               
                   
               
               
                 acaaaaaaac gctgccaggt tttanaagca gttctggtct caaaaccatc aggatcctgc    180 
               
               
                   
               
               
                 caccagggtt cttttgaaat agtaccacat gtaaaaggga atttggcttt cacttcatct    240 
               
               
                   
               
               
                 aatcactgaa ttgtcaggct ttgattgata attgtagaaa taagtagcct tctgttgtgg    300 
               
               
                   
               
               
                 gaataagtta taatcagtat tcatctcttt gttttttgtc actcttttct ctctnattgt    360 
               
               
                   
               
               
                 gtcatttgta ctgtttgaaa aatatttctt ctataaaatt aaactaacct gccttaaaaa    420 
               
               
                   
               
               
                 aaaaaaaaaa aaaaaaa                                                   437 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 75 
               
               
                 &lt;211&gt; LENGTH: 579 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (440) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (513) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (539) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (551) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 75 
               
               
                   
               
               
                 ctccgtcgcc gccaagatga tgtgcggggc gccctccgcc acgcagccgg ccaccgccga     60 
               
               
                   
               
               
                 gacccagcac atcgccgacc aggtgaggtc ccagcttgaa gagaaagaaa acaagaagtt    120 
               
               
                   
               
               
                 ccctgtgttt aaggccgtgt cattcaagag ccaggtggtc gcggggacaa actacttcat    180 
               
               
                   
               
               
                 caaggtgcac gtcggcgacg aggacttcgt acacctgcga gtgttccaat ctctccctca    240 
               
               
                   
               
               
                 tgaaaacaag cccttgacct tatctaacta ccagaccaac aaagccaagc atgatgagct    300 
               
               
                   
               
               
                 gacctatttc tgatcctgac tttggacaag gcccttcagc cagaagactg acaaagtcat    360 
               
               
                   
               
               
                 cctccgtcta ccagagcgtg cacttgtgat cctaaaataa gcttcatctc cgggctgtgc    420 
               
               
                   
               
               
                 ccttggggtg gaaggggcan gatctgcact gcttttgcat ttctcttcct aaatttcatt    480 
               
               
                   
               
               
                 gtgttgattc tttccttcca ataggtgatc ttnattactt tcagaatatt ttccaaatna    540 
               
               
                   
               
               
                 gatatatttt naaaatcctt aaaaaaaaaa aaaaaaaaa                           579 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 76 
               
               
                 &lt;211&gt; LENGTH: 666 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (411) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (470) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (476) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (491) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (506) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (527) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (560) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (570) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (632) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (636) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (643) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (650) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (654) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (658) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 76 
               
               
                   
               
               
                 gtttatccta tctctccaac cagattgtca gctccttgag ggcaagagcc acagtatatt     60 
               
               
                   
               
               
                 tccctgtttc ttccacagtg cctaataata ctgtggaact aggttttaat aattttttaa    120 
               
               
                   
               
               
                 ttgatgttgt tatgggcagg atggcaacca gaccattgtc tcagagcagg tgctggctct    180 
               
               
                   
               
               
                 ttcctggcta ctccatgttg gctagcctct ggtaacctct tacttattat cttcaggaca    240 
               
               
                   
               
               
                 ctcactacag ggaccaggga tgatgcaaca tccttgtctt tttatgacag gatgtttgct    300 
               
               
                   
               
               
                 cagcttctcc aacaataaaa agcacgtggt aaaacacttg cggatattct ggactgtttt    360 
               
               
                   
               
               
                 taaaaaatat acagtttacc gaaaatcata ttatcttaca atgaaaagga ntttatagat    420 
               
               
                   
               
               
                 cagccagtga acaacctttt cccaccatac aaaaattcct tttcccgaan gaaaanggct    480 
               
               
                   
               
               
                 ttctcaataa ncctcacttt cttaanatct tacaagatag ccccganatc ttatcgaaac    540 
               
               
                   
               
               
                 tcattttagg caaatatgan ttttattgtn cgttacttgt ttcaaaattt ggtattgtga    600 
               
               
                   
               
               
                 atatcaatta ccacccccat ctcccatgaa anaaanggga aanggtgaan ttcntaancg    660 
               
               
                   
               
               
                 cttaaa                                                               666 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 77 
               
               
                 &lt;211&gt; LENGTH: 396 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (31) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (54) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (125) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (128) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (136) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (163) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (168) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (198) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 77 
               
               
                   
               
               
                 ctgcagcccg ggggatccac taatctacca nggttatttg gcagctaatt ctanatttgg     60 
               
               
                   
               
               
                 atcattgccc aaagttgcac ttgctggtct cttgggattt ggccttggaa aggtatcata    120 
               
               
                   
               
               
                 catanganta tgccanaata aattccattt ttttgaaaat canctccntg gggctggttt    180 
               
               
                   
               
               
                 tggtccacag cataacangc actgcctcct tacctgtgag gaatgcaaaa taaagcatgg    240 
               
               
                   
               
               
                 attaagtgag aagggagact ctcagccttc agcttcctaa attctgtgtc tgtgactttc    300 
               
               
                   
               
               
                 gaagtttttt aaacctctga atttgtacac atttaaaatt tcaagtgtac tttaaaataa    360 
               
               
                   
               
               
                 aatacttcta atgggaacaa aaaaaaaaaa aaaaaa                              396 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 78 
               
               
                 &lt;211&gt; LENGTH: 793 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (309) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (492) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (563) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (657) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (660) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (703) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (708) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (710) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (711) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (732) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (740) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (748) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (758) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (762) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (765) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (787) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 78 
               
               
                   
               
               
                 gcatcctagc cgccgactca cacaaggcag gtgggtgagg aaatccagag ttgccatgga     60 
               
               
                   
               
               
                 gaaaattcca gtgtcagcat tcttgctcct tgtggccctc tcctacactc tggccagaga    120 
               
               
                   
               
               
                 taccacagtc aaacctggag ccaaaaagga cacaaaggac tctcgaccca aactgcccca    180 
               
               
                   
               
               
                 gaccctctcc agaggttggg gtgaccaact catctggact cagacatatg aagaagctct    240 
               
               
                   
               
               
                 atataaatcc aagacaagca acaaaccctt gatgattatt catcacttgg atgagtgccc    300 
               
               
                   
               
               
                 acacagtcna gctttaaaga aagtgtttgc tgaaaataaa gaaatccaga aattggcaga    360 
               
               
                   
               
               
                 gcagtttgtc ctcctcaatc tggtttatga aacaactgac aaacaccttt ctcctgatgg    420 
               
               
                   
               
               
                 ccagtatgtc ccaggattat gtttgttgac ccatctctga cagttgaagc cgatatcctg    480 
               
               
                   
               
               
                 ggaagatatt cnaaccgtct ctatgcttac aaactgcaga tacgctctgt tgcttgacac    540 
               
               
                   
               
               
                 atgaaaaagc tctcaagttg ctnaaaatga attgtaagaa aaaaaatctc cagccttctg    600 
               
               
                   
               
               
                 tctgtcggct tgaaaattga aaccagaaaa atgtgaaaaa tggctattgt ggaacanatn    660 
               
               
                   
               
               
                 gacacctgat taggttttgg ttatgttcac cactattttt aanaaaanan nttttaaaat    720 
               
               
                   
               
               
                 ttggttcaat tntctttttn aaacaatntg tttctacntt gnganctgat ttctaaaaaa    780 
               
               
                   
               
               
                 aataatnttt ggc                                                       793 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 79 
               
               
                 &lt;211&gt; LENGTH: 456 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (89) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (195) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (255) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (263) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (266) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (286) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (353) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (384) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (423) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (425) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (436) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (441) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 79 
               
               
                   
               
               
                 actagtatgg ggtgggaggc cccacccttc tcccctaggc gctgttcttg ctccaaaggg     60 
               
               
                   
               
               
                 ctccgtggag agggactggc agagctgang ccacctgggg ctggggatcc cactcttctt    120 
               
               
                   
               
               
                 gcagctgttg agcgcaccta accactggtc atgcccccac ccctgctctc cgcacccgct    180 
               
               
                   
               
               
                 tcctcccgac cccangacca ggctacttct cccctcctct tgcctccctc ctgcccctgc    240 
               
               
                   
               
               
                 tgcctctgat cgtangaatt gangantgtc ccgccttgtg gctganaatg gacagtggca    300 
               
               
                   
               
               
                 ggggctggaa atgggtgtgt gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gcnccccccc    360 
               
               
                   
               
               
                 tgcaagaccg agattgaggg aaancatgtc tgctgggtgt gaccatgttt cctctccata    420 
               
               
                   
               
               
                 aantncccct gtgacnctca naaaaaaaaa aaaaaa                              456 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 80 
               
               
                 &lt;211&gt; LENGTH: 284 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (283) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 80 
               
               
                   
               
               
                 ctttgtacct ctagaaaaga taggtattgt gtcatgaaac ttgagtttaa attttatata     60 
               
               
                   
               
               
                 taaaactaaa agtaatgctc actttagcaa cacatactaa aattggaacc atactgagaa    120 
               
               
                   
               
               
                 gaatagcatg acctccgtgc aaacaggaca agcaaatttg tgatgtgttg attaaaaaga    180 
               
               
                   
               
               
                 aataaataaa tgtgtatatg tgtaacttgt atgtttatgt ggaatacaga ttgggaaata    240 
               
               
                   
               
               
                 aaatgtattt cttactgtga aaaaaaaaaa aaaaaaaaaa aana                     284 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 81 
               
               
                 &lt;211&gt; LENGTH: 671 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (388) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (505) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (600) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (603) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (615) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (642) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (644) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (660) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 81 
               
               
                   
               
               
                 gccaccaaca ttccaagcta ccctgggtac ctttgtgcag tagaagctag tgagcatgtg     60 
               
               
                   
               
               
                 agcaagcggt gtgcacacgg agactcatcg ttataattta ctatctgcca agagtagaaa    120 
               
               
                   
               
               
                 gaaaggctgg ggatatttgg gttggcttgg ttttgatttt ttgcttgttt gtttgttttg    180 
               
               
                   
               
               
                 tactaaaaca gtattatctt ttgaatatcg tagggacata agtatataca tgttatccaa    240 
               
               
                   
               
               
                 tcaagatggc tagaatggtg cctttctgag tgtctaaaac ttgacacccc tggtaaatct    300 
               
               
                   
               
               
                 ttcaacacac ttccactgcc tgcgtaatga agttttgatt catttttaac cactggaatt    360 
               
               
                   
               
               
                 tttcaatgcc gtcattttca gttagatnat tttgcacttt gagattaaaa tgccatgtct    420 
               
               
                   
               
               
                 atttgattag tcttattttt ttatttttac aggcttatca gtctcactgt tggctgtcat    480 
               
               
                   
               
               
                 tgtgacaaag tcaaataaac ccccnaggac aacacacagt atgggatcac atattgtttg    540 
               
               
                   
               
               
                 acattaagct ttggccaaaa aatgttgcat gtgttttacc tcgacttgct aaatcaatan    600 
               
               
                   
               
               
                 canaaaggct ggctnataat gttggtggtg aaataattaa tnantaacca aaaaaaaaan    660 
               
               
                   
               
               
                 aaaaaaaaaa a                                                         671 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 82 
               
               
                 &lt;211&gt; LENGTH: 217 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (35) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 82 
               
               
                   
               
               
                 ctgcagatgt ttcttgaatg ctttgtcaaa ttaanaaagt taaagtgcaa taatgtttga     60 
               
               
                   
               
               
                 agacaataag tggtggtgta tcttgtttct aataagataa acttttttgt ctttgcttta    120 
               
               
                   
               
               
                 tcttattagg gagttgtatg tcagtgtata aaacatactg tgtggtataa caggcttaat    180 
               
               
                   
               
               
                 aaattcttta aaaggaaaaa aaaaaaaaaa aaaaaaa                             217 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 83 
               
               
                 &lt;211&gt; LENGTH: 460 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (104) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (118) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (172) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (401) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (422) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (423) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (444) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (449) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 83 
               
               
                   
               
               
                 cgcgagtggg agcaccagga tctcgggctc ggaacgagac tgcacggatt gttttaagaa     60 
               
               
                   
               
               
                 aatggcagac aaaccagaca tgggggaaat cgccagcttc gatnaggcca agctgaanaa    120 
               
               
                   
               
               
                 aacggagacg caggagaaga acaccctgcc gaccaaagag accattgagc angagaagcg    180 
               
               
                   
               
               
                 gagtgaaatt tcctaagatc ctggaggatt tcctaccccc gtcctcttcg agaccccagt    240 
               
               
                   
               
               
                 cgtgatgtgg aggaagagcc acctgcaaga tggacacgag ccacaagctg cactgtgaac    300 
               
               
                   
               
               
                 ctgggcactc cgcgccgatg ccaccggcct gtgggtctct gaagggaccc cccccaatcg    360 
               
               
                   
               
               
                 gactgccaaa ttctccggtt tgccccggga tattatacaa nattatttgt atgaataatg    420 
               
               
                   
               
               
                 annataaaac acacctcgtg gcancaaana aaaaaaaaaa                          460 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 84 
               
               
                 &lt;211&gt; LENGTH: 323 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (70) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (138) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (178) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (197) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (228) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (242) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (244) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (287) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (311) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 84 
               
               
                   
               
               
                 tggtggatct tggctctgtg gagctgctgg gacgggatct aaaagactat tctggaagct     60 
               
               
                   
               
               
                 gtggtccaan gcattttgct ggcttaacgg gtcccggaac aaaggacacc agctctctaa    120 
               
               
                   
               
               
                 aattgaagtt tacccganat aacaatcttt tgggcagaga tgcctatttt aacaaacncc    180 
               
               
                   
               
               
                 gtccctgcgc aacaacnaac aatctctggg aaataccggc catgaacntg ctgtctcaat    240 
               
               
                   
               
               
                 cnancatctc tctagctgac cgatcatatc gtcccagatt actacanatc ataataattg    300 
               
               
                   
               
               
                 atttcctgta naaaaaaaaa aaa                                            323 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 85 
               
               
                 &lt;211&gt; LENGTH: 771 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (63) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (426) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (471) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (487) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (521) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (554) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (583) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (586) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (606) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (609) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (615) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (652) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (686) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (691) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (694) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (695) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (706) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (713) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (730) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (732) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (743) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (751) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 85 
               
               
                   
               
               
                 aaactgggta ctcaacactg agcagatctg ttctttgagc taaaaaccat gtgctgtacc     60 
               
               
                   
               
               
                 aanagtttgc tcctggctgc tttgatgtca gtgctgctac tccacctctg cggcgaatca    120 
               
               
                   
               
               
                 gaagcaagca actttgactg ctgtcttgga tacacagacc gtattcttca tcctaaattt    180 
               
               
                   
               
               
                 attgtgggct tcacacggca gctggccaat gaaggctgtg acatcaatgc tatcatcttt    240 
               
               
                   
               
               
                 cacacaaaga aaaagttgtc tgtgtgcgca aatccaaaac agacttgggt gaaatatatt    300 
               
               
                   
               
               
                 gtgcgtctcc tcagtaaaaa agtcaagaac atgtaaaaac tgtggctttt ctggaatgga    360 
               
               
                   
               
               
                 attggacata gcccaagaac agaaagaact tgctggggtt ggaggtttca cttgcacatc    420 
               
               
                   
               
               
                 atgganggtt tagtgcttat cttatttgtg cctcctggac ttgtccaatt natgaagtta    480 
               
               
                   
               
               
                 atcatattgc atcatanttt gctttgttta acatcacatt naaattaaac tgtattttat    540 
               
               
                   
               
               
                 gttatttata gctntaggtt ttctgtgttt aactttttat acnaantttc ctaaactatt    600 
               
               
                   
               
               
                 ttggtntant gcaanttaaa aattatattt ggggggggaa taaatattgg antttctgca    660 
               
               
                   
               
               
                 gccacaagct ttttttaaaa aaccantaca nccnngttaa atggtnggtc ccnaatggtt    720 
               
               
                   
               
               
                 tttgcttttn antagaaaat ttnttagaac natttgaaaa aaaaaaaaaa a             771 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 86 
               
               
                 &lt;211&gt; LENGTH: 628 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (162) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (249) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (266) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (348) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (407) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (427) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (488) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (518) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (545) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (566) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (569) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (597) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (598) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (611) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (617) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (621) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (624) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 86 
               
               
                   
               
               
                 actagtttgc tttacatttt tgaaaagtat tatttttgtc caagtgctta tcaactaaac     60 
               
               
                   
               
               
                 cttgtgttag gtaagaatgg aatttattaa gtgaatcagt gtgacccttc ttgtcataag    120 
               
               
                   
               
               
                 attatcttaa agctgaagcc aaaatatgct tcaaaagaaa angactttat tgttcattgt    180 
               
               
                   
               
               
                 agttcataca ttcaaagcat ctgaactgta gtttctatag caagccaatt acatccataa    240 
               
               
                   
               
               
                 gtggagaang aaatagatta atgtcnaagt atgattggtg gagggagcaa ggttgaagat    300 
               
               
                   
               
               
                 aatctggggt tgaaattttc tagttttcat tctgtacatt tttagttnga catcagattt    360 
               
               
                   
               
               
                 gaaatattaa tgtttacctt tcaatgtgtg gtatcagctg gactcantaa cacccctttc    420 
               
               
                   
               
               
                 ttccctnggg gatggggaat ggattattgg aaaatggaaa gaaaaaagta cttaaagcct    480 
               
               
                   
               
               
                 tcctttcnca gtttctggct cctaccctac tgatttancc agaataagaa aacattttat    540 
               
               
                   
               
               
                 catcntctgc tttattccca ttaatnaant tttgatgaat aaatctgctt ttatgcnnac    600 
               
               
                   
               
               
                 ccaaggaatt nagtggnttc ntcnttgt                                       628 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 87 
               
               
                 &lt;211&gt; LENGTH: 518 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (384) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (421) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (486) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 87 
               
               
                   
               
               
                 ttttttattt tttttagaga gtagttcagc ttttatttat aaatttattg cctgttttat     60 
               
               
                   
               
               
                 tataacaaca ttatactgtt tatggtttaa tacatatggt tcaaaatgta taatacatca    120 
               
               
                   
               
               
                 agtagtacag ttttaaaatt ttatgcttaa aacaagtttt gtgtaaaaaa tgcagataca    180 
               
               
                   
               
               
                 ttttacatgg caaatcaatt tttaagtcat cctaaaaatt gatttttttt tgaaatttaa    240 
               
               
                   
               
               
                 aaacacattt aatttcaatt tctctcttat ataaccttta ttactatagc atggtttcca    300 
               
               
                   
               
               
                 ctacagttta acaatgcagc aaaattccca tttcacggta aattgggttt taagcggcaa    360 
               
               
                   
               
               
                 ggttaaaatg ctttgaggat cctnaatacc ctttgaactt caaatgaagg ttatggttgt    420 
               
               
                   
               
               
                 naatttaacc ctcatgccat aagcagaagc acaagtttag ctgcattttg ctctaaactg    480 
               
               
                   
               
               
                 taaaancgag ccccccgttg aaaaagcaaa agggaccc                            518 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 88 
               
               
                 &lt;211&gt; LENGTH: 1844 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 88 
               
               
                   
               
               
                 gagacagtga atcctagtat caaaggattt ttggcctcag aaaaagttgt tgattatttt     60 
               
               
                   
               
               
                 tattttattt tatttttcga gactccgtct caaaaaaaaa aaaaaaaaaa agaatcacaa    120 
               
               
                   
               
               
                 ggtatttgct aaagcatttt gagctgcttg gaaaaaggga agtagttgca gtagagtttc    180 
               
               
                   
               
               
                 ttccatcttc ttggtgctgg gaagccatat atgtgtcttt tactcaagct aaggggtata    240 
               
               
                   
               
               
                 agcttatgtg ttgaatttgc tacatctata tttcacatat tctcacaata agagaatttt    300 
               
               
                   
               
               
                 gaaatagaaa tatcatagaa catttaagaa agtttagtat aaataatatt ttgtgtgttt    360 
               
               
                   
               
               
                 taatcccttt gaagggatct atccaaagaa aatattttac actgagctcc ttcctacacg    420 
               
               
                   
               
               
                 tctcagtaac agatcctgtg ttagtctttg aaaatagctc attttttaaa tgtcagtgag    480 
               
               
                   
               
               
                 tagatgtagc atacatatga tgtataatga cgtgtattat gttaacaatg tctgcagatt    540 
               
               
                   
               
               
                 ttgtaggaat acaaaacatg gcctttttta taagcaaaac gggccaatga ctagaataac    600 
               
               
                   
               
               
                 acatagggca atctgtgaat atgtattata agcagcattc cagaaaagta gttggtgaaa    660 
               
               
                   
               
               
                 taattttcaa gtcaaaaagg gatatggaaa gggaattatg agtaacctct attttttaag    720 
               
               
                   
               
               
                 ccttgctttt aaattaaacg ctacagccat ttaagccttg aggataataa agcttgagag    780 
               
               
                   
               
               
                 taataatgtt aggttagcaa aggtttagat gtatcacttc atgcatgcta ccatgatagt    840 
               
               
                   
               
               
                 aatgcagctc ttcgagtcat ttctggtcat tcaagatatt cacccttttg cccatagaaa    900 
               
               
                   
               
               
                 gcaccctacc tcacctgctt actgacattg tcttagctga tcacaagatc attatcagcc    960 
               
               
                   
               
               
                 tccattattc cttactgtat ataaaataca gagttttata ttttcctttc ttcgtttttc   1020 
               
               
                   
               
               
                 accatattca aaacctaaat ttgtttttgc agatggaatg caaagtaatc aagtgttcgt   1080 
               
               
                   
               
               
                 gctttcacct agaagggtgt ggtcctgaag gaaagaggtc cctaaatatc ccccaccctg   1140 
               
               
                   
               
               
                 ggtgctcctc cttccctggt accctgacta ccagaagtca ggtgctagag cagctggaga   1200 
               
               
                   
               
               
                 agtgcagcag cctgtgcttc cacagatggg ggtgctgctg caacaaggct ttcaatgtgc   1260 
               
               
                   
               
               
                 ccatcttagg gggagaagct agatcctgtg cagcagcctg gtaagtcctg aggaggttcc   1320 
               
               
                   
               
               
                 attgctcttc ctgctgctgt cctttgcttc tcaacggggc tcgctctaca gtctagagca   1380 
               
               
                   
               
               
                 catgcagcta acttgtgcct ctgcttatgc atgagggtta aattaacaac cataaccttc   1440 
               
               
                   
               
               
                 atttgaagtt caaaggtgta ttcaggatcc tcaaagcatt ttaaccttgc cgcttaaaac   1500 
               
               
                   
               
               
                 ccaatttacc gtgaaatggg aattttgctg cattgttaaa ctgtagtgga aaccatgcta   1560 
               
               
                   
               
               
                 tagtaataaa ggttatataa gagagaaatt gaaattaaat gtgtttttaa atttcaaaaa   1620 
               
               
                   
               
               
                 aaaatcaatc tttaggatga cttaaaaatt gatttgccat gtaaaatgta tctgcatttt   1680 
               
               
                   
               
               
                 ttacacaaaa cttgttttaa gcataaaatt ttaaaactgt actacttgat gtattataca   1740 
               
               
                   
               
               
                 ttttgaacca tatgtattaa accataaaca gtataatgtt gttataataa aacaggcaat   1800 
               
               
                   
               
               
                 aaatttataa ataaaagctg aaaaaaaaaa aaaaaaaaaa aaaa                    1844 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 89 
               
               
                 &lt;211&gt; LENGTH: 523 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (288) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (352) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (369) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (398) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (475) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (511) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (513) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 89 
               
               
                   
               
               
                 tttttttttt tttttttagt caatccacat ttattgatca cttattatgt accaggcact     60 
               
               
                   
               
               
                 gggataaaga tgactgttag tcactcacag taaggaagaa aactagcaaa taagacgatt    120 
               
               
                   
               
               
                 acaatatgat gtagaaaatg ctaagccaga gatatagaaa ggtcctattg ggtccttctg    180 
               
               
                   
               
               
                 tcaccttgtc tttccacatc cctacccttc acaggccttc cctccagctt cctgcccccg    240 
               
               
                   
               
               
                 ctccccactg cagatcccct gggattttgc ctagagctaa acgagganat gggccccctg    300 
               
               
                   
               
               
                 gccctggcat gacttgaacc caaccacaga ctgggaaagg gagcctttcg anagtggatc    360 
               
               
                   
               
               
                 actttgatna gaaaacacat agggaattga agagaaantc cccaaatggc cacccgtgct    420 
               
               
                   
               
               
                 ggtgctcaag aaaagtttgc agaatggata aatgaaggat caagggaatt aatanatgaa    480 
               
               
                   
               
               
                 taattgaatg gtggctcaat aagaatgact ncnttgaatg acc                      523 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 90 
               
               
                 &lt;211&gt; LENGTH: 604 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (563) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 90 
               
               
                   
               
               
                 ccagtgtggt ggaatgcaaa gattaccccg gaagctttcg agaagctggg attccctgca     60 
               
               
                   
               
               
                 gcaaaggaaa tagccaatat gtgtcgtttc tatgaaatga agccagaccg agatgtcaat    120 
               
               
                   
               
               
                 ctcacccacc aactaaatcc caaagtcaaa agcttcagcc agtttatctc agagaaccag    180 
               
               
                   
               
               
                 gggagccttc aagggcatgt agaaaatcag ctgttcagat aggcctctgc accacacagc    240 
               
               
                   
               
               
                 ctctttcctc tctgatcctt ttcctcttta cggcacaaca ttcatgtttg acagaacatg    300 
               
               
                   
               
               
                 ctggaatgca attgtttgca acaccgaagg atttcctgcg gtcgcctctt cagtaggaag    360 
               
               
                   
               
               
                 cactgcattg gtgataggac acggtaattt gattcacatt taacttgcta gttagtgata    420 
               
               
                   
               
               
                 aggggtggta cacctgtttg gtaaaatgag aagcctcgga aacttgggag cttctctcct    480 
               
               
                   
               
               
                 accactaatg gggagggcag attattactg ggatttctcc tggggtgaat taatttcaag    540 
               
               
                   
               
               
                 ccctaattgc tgaaattccc ctnggcaggc tccagttttc tcaactgcat tgcaaaattc    600 
               
               
                   
               
               
                 cccc                                                                 604 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 91 
               
               
                 &lt;211&gt; LENGTH: 858 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (570) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (591) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (655) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (664) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (667) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (683) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (711) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (759) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (760) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (765) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (777) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (787) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (792) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (794) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (801) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (804) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (809) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (817) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (820) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 91 
               
               
                   
               
               
                 tttttttttt ttttttttta tgattattat tttttttatt gatctttaca tcctcagtgt     60 
               
               
                   
               
               
                 tggcagagtt tctgatgctt aataaacatt tgttctgatc agataagtgg aaaaaattgt    120 
               
               
                   
               
               
                 catttcctta ttcaagccat gcttttctgt gatattctga tcctagttga acatacagaa    180 
               
               
                   
               
               
                 ataaatgtct aaaacagcac ctcgattctc gtctataaca ggactaagtt cactgtgatc    240 
               
               
                   
               
               
                 ttaaataagc ttggctaaaa tgggacatga gtggaggtag tcacacttca gcgaagaaag    300 
               
               
                   
               
               
                 agaatctcct gtataatctc accaggagat tcaacgaatt ccaccacact ggactagtgg    360 
               
               
                   
               
               
                 atcccccggg ctgcaggaat tcgatatcaa gcttatcgat accgtcgacc tcgagggggg    420 
               
               
                   
               
               
                 gcccggtacc caattcgccc tatagtgagt cgtattacgc gcgctcactg gccgtcgttt    480 
               
               
                   
               
               
                 tacaacgtcg tgactgggaa aaccctggcg ttacccaact taatcgcctt gcagcacatc    540 
               
               
                   
               
               
                 cccctttcgc cagctggcgt aatagcgaan agcccgcacc gatcgccctt ncaacagttg    600 
               
               
                   
               
               
                 cgcagcctga atggcgaatg ggacgcgccc tgtagcggcg cattaaagcg cggcngggtg    660 
               
               
                   
               
               
                 tggnggntcc cccacgtgac cgntacactt ggcagcgcct tacgccggtc nttcgctttc    720 
               
               
                   
               
               
                 ttcccttcct ttctcgcacc gttcgccggg tttccccgnn agctnttaat cgggggnctc    780 
               
               
                   
               
               
                 cctttanggg tncnaattaa nggnttacng gaccttngan cccaaaaact ttgattaggg    840 
               
               
                   
               
               
                 ggaaggtccc cgaagggg                                                  858 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 92 
               
               
                 &lt;211&gt; LENGTH: 585 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (317) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (319) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (320) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (321) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (325) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (327) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (328) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (330) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (331) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (332) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (460) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (462) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (483) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (485) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (487) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (523) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (538) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (566) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (584) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 92 
               
               
                   
               
               
                 gttgaatctc ctggtgagat tatacaggag attctctttc ttcgctgaag tgtgactacc     60 
               
               
                   
               
               
                 tccactcatg tcccatttta gccaagctta tttaagatca cagtgaactt agtcctgtta    120 
               
               
                   
               
               
                 tagacgagaa tcgaggtgct gttttagaca tttatttctg tatgttcaac taggatcaga    180 
               
               
                   
               
               
                 atatcacaga aaagcatggc ttgaataagg aaatgacaat tttttccact tatctgatca    240 
               
               
                   
               
               
                 gaacaaatgt ttattaagca tcagaaactc tgccaacact gaggatgtaa agatcaataa    300 
               
               
                   
               
               
                 aaaaaataat aatcatnann naaanannan nngaagggcg gccgccaccg cggtggagct    360 
               
               
                   
               
               
                 ccagcttttg ttccctttag tgagggttaa ttgcgcgctt ggcgttaatc atggtcatag    420 
               
               
                   
               
               
                 ctgtttcctg tgtgaaattg ttatccggct cacaattccn cncaacatac gagccgggaa    480 
               
               
                   
               
               
                 gcntnangtg taaaagcctg ggggtgccta attgagtgag ctnactcaca ttaattgngt    540 
               
               
                   
               
               
                 tgcgctccac ttgcccgctt ttccantccg ggaaacctgt tcgnc                    585 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 93 
               
               
                 &lt;211&gt; LENGTH: 567 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (82) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (158) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (230) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (232) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (253) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (266)..(287) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (295) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (303) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (307) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (314) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (349) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (352) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (354) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (356) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (366) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (369) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (379) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (382) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (386) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (393) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (404) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (427) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (428) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (446) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (450) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (452) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (453) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (454) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (459) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (462) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (480) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (481) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (483) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (488) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (493) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (501) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (509) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (511) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (512) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (518) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (520) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (525) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (526) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (532) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (541) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (557) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 93 
               
               
                   
               
               
                 cggcagtgtt gctgtctgcg tgtccacctt ggaatctggc tgaactggct gggaggacca     60 
               
               
                   
               
               
                 agactgcggc tggggtgggc anggaaggga accgggggct gctgtgaagg atcttggaac    120 
               
               
                   
               
               
                 ttccctgtac ccaccttccc cttgcttcat gtttgtanag gaaccttgtg ccggccaagc    180 
               
               
                   
               
               
                 ccagtttcct tgtgtgatac actaatgtat ttgctttttt tgggaaatan anaaaaatca    240 
               
               
                   
               
               
                 attaaattgc tantgtttct ttgaannnnn nnnnnnnnnn nnnnnnnggg ggggncgccc    300 
               
               
                   
               
               
                 ccncggngga aacnccccct tttgttccct ttaattgaaa ggttaattng cncncntggc    360 
               
               
                   
               
               
                 gttaanccnt gggccaaanc tngttncccg tgntgaaatt gttnatcccc tcccaaattc    420 
               
               
                   
               
               
                 ccccccnncc ttccaaaccc ggaaancctn annntgttna ancccggggg gttgcctaan    480 
               
               
                   
               
               
                 ngnaattnaa ccnaaccccc ntttaaatng nntttgcncn ccacnngccc cnctttccca    540 
               
               
                   
               
               
                 nttcggggaa aaccctntcc gtgccca                                        567 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 94 
               
               
                 &lt;211&gt; LENGTH: 620 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (169) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (171) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (222) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (472) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (528) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (559) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (599) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 94 
               
               
                   
               
               
                 actagtcaaa aatgctaaaa taatttggga gaaaatattt tttaagtagt gttatagttt     60 
               
               
                   
               
               
                 catgtttatc ttttattatg ttttgtgaag ttgtgtcttt tcactaatta cctatactat    120 
               
               
                   
               
               
                 gccaatattt ccttatatct atccataaca tttatactac atttgtaana naatatgcac    180 
               
               
                   
               
               
                 gtgaaactta acactttata aggtaaaaat gaggtttcca anatttaata atctgatcaa    240 
               
               
                   
               
               
                 gttcttgtta tttccaaata gaatggactt ggtctgttaa gggctaagga gaagaggaag    300 
               
               
                   
               
               
                 ataaggttaa aagttgttaa tgaccaaaca ttctaaaaga aatgcaaaaa aaaagtttat    360 
               
               
                   
               
               
                 tttcaagcct tcgaactatt taaggaaagc aaaatcattt cctaaatgca tatcatttgt    420 
               
               
                   
               
               
                 gagaatttct cattaatatc ctgaatcatt catttcacta aggctcatgt tnactccgat    480 
               
               
                   
               
               
                 atgtctctaa gaaagtacta tttcatggtc caaacctggt tgccatantt gggtaaaggc    540 
               
               
                   
               
               
                 tttcccttaa gtgtgaaant atttaaaatg aaattttcct ctttttaaaa attctttana    600 
               
               
                   
               
               
                 agggttaagg gtgttgggga                                                620 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 95 
               
               
                 &lt;211&gt; LENGTH: 470 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (61) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (67) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (79) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (89) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (106) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (213) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (271) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (281) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (330) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (356) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (387) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (432) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (448) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 95 
               
               
                   
               
               
                 ctcgaccttc tctgcacagc ggatgaaccc tgagcagctg aagaccagaa aagccactat     60 
               
               
                   
               
               
                 nactttntgc ttaattcang agcttacang attcttcaaa gagtgngtcc agcatccttt    120 
               
               
                   
               
               
                 gaaacatgag ttcttaccag cagaagcaga cctttacccc accacctcag cttcaacagc    180 
               
               
                   
               
               
                 agcaggtgaa acaacccatc cagcctccac ctnaggaaat atttgttccc acaaccaagg    240 
               
               
                   
               
               
                 agccatgcca ctcaaaggtt ccacaacctg naaacacaaa nattccagag ccaggctgta    300 
               
               
                   
               
               
                 ccaaggtccc tgagccaggg ctgtaccaan gtccctgagc caggttgtac caangtccct    360 
               
               
                   
               
               
                 gagccaggat gtaccaaggt ccctgancca ggttgtccaa ggtccctgag ccaggctaca    420 
               
               
                   
               
               
                 ccaagggcct gngccaggca gcatcaangt ccctgaccaa ggcttatcaa               470 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 96 
               
               
                 &lt;211&gt; LENGTH: 718 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (299) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (311) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (360) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (426) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (538) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (540) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (542) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (553) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (563) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (565) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (592) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (603) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (604) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (618) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (633) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (647) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (649) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (651) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (653) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (662) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (668) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (682) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (691) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (710) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (715) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 96 
               
               
                   
               
               
                 tttttttttt tttttttttt ggaattaaaa gcaatttaat gagggcagag caggaaacat     60 
               
               
                   
               
               
                 gcatttcttt tcattcgaat cttcagatga accctgagca gccgaagacc agaaaagcca    120 
               
               
                   
               
               
                 tgaagacttt ctgcttaatt caggggctta caggattctt cagagtgtgt gtgaacaaaa    180 
               
               
                   
               
               
                 gctttatagt acgtattttt aggatacaaa taagagagag actatggctt ggggtgagaa    240 
               
               
                   
               
               
                 tgtactgatt acaaggtcta cagacaatta agacacagaa acagatggga agagggtgnc    300 
               
               
                   
               
               
                 cagcatctgg nggttggctt ctcaagggct tgtctgtgca ccaaattact tctgcttggn    360 
               
               
                   
               
               
                 cttctgctga gctgggcctg gagtgaccgt tgaaggacat ggctctggta cctttgtgta    420 
               
               
                   
               
               
                 gcctgncaca ggaactttgg tgtatccttg ctcaggaact ttgatggcac ctggctcagg    480 
               
               
                   
               
               
                 aaacttgatg aagccttggt caagggacct tgatgcttgc tggctcaggg accttggngn    540 
               
               
                   
               
               
                 ancctgggct canggacctt tgncncaacc ttggcttcaa gggacccttg gnacatcctg    600 
               
               
                   
               
               
                 gcnnagggac ccttgggncc aaccctgggc ttnagggacc ctttggntnc nanccttggc    660 
               
               
                   
               
               
                 tnaagggnac ccttggcaac ancctgggct ntggaaaatc ttttggggtn ccccnggg      718 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 97 
               
               
                 &lt;211&gt; LENGTH: 441 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (12) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (308) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 97 
               
               
                   
               
               
                 gggaccatac anagtattcc tctcttcaca ccaggaccag ccactgttgc agcatgagtt     60 
               
               
                   
               
               
                 cccagcagca gaagcagccc tgcatcccac cccctcagct tcagcagcag caggtgaaac    120 
               
               
                   
               
               
                 agccttgcca gcctccacct caggaaccat gcatccccaa aaccaaggag ccctgccacc    180 
               
               
                   
               
               
                 ccaaggtgcc tgagccctgc caccccaaag tgcctgagcc ctgccagccc aaggttccag    240 
               
               
                   
               
               
                 agccatgcca ccccaaggtg cctgagccct gcccttcaat agtcactcca gcaccagccc    300 
               
               
                   
               
               
                 agcagaanac caagcagaag taatgtggtc cacagccatg cccttgagga gccggccacc    360 
               
               
                   
               
               
                 agatgctgaa tcccctatcc cattctgtgt atgagtccca tttgccttgc aattagcatt    420 
               
               
                   
               
               
                 ctgtctcccc caaaaaaaaa a                                              441 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 98 
               
               
                 &lt;211&gt; LENGTH: 600 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (285) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (349) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (489) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (496) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (583) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 98 
               
               
                   
               
               
                 gtattcctct cttcacacca ggaccagcca ctgttgcagc atgagttccc agcagcagaa     60 
               
               
                   
               
               
                 gcagccctgc atcccacccc ctcagcttca gcagcagcag gtgaaacagc cttgccagcc    120 
               
               
                   
               
               
                 tccacctcag gaaccatgca tccccaaaac caaggagccc tgccacccca aggtgcctga    180 
               
               
                   
               
               
                 gccctgccac cccaaagtgc ctgagccctg ccagcccaag gttccagagc catgccaccc    240 
               
               
                   
               
               
                 caaggtgcct gagccctgcc cttcaatagt cactccagca ccagcccagc agaanaccaa    300 
               
               
                   
               
               
                 gcagaagtaa tgtggtccac agccatgccc ttgaggagcc ggccaccana tgctgaatcc    360 
               
               
                   
               
               
                 cctatcccat tctgtgtatg agtcccattt gccttgcaat tagcattctg tctcccccaa    420 
               
               
                   
               
               
                 aaaagaatgt gctatgaagc tttctttcct acacactctg agtctctgaa tgaagctgaa    480 
               
               
                   
               
               
                 ggtcttaant acaganctag ttttcagctg ctcagaattc tctgaagaaa agatttaaga    540 
               
               
                   
               
               
                 tgaaaggcaa atgattcagc tccttattac cccattaaat tcnctttcaa ttccaaaaaa    600 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 99 
               
               
                 &lt;211&gt; LENGTH: 667 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (345) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (562) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (635) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 99 
               
               
                   
               
               
                 actagtgact gagttcctgg caaagaaatt tgacctggac cagttgataa ctcatgtttt     60 
               
               
                   
               
               
                 accatttaaa aaaatcagtg aaggatttga gctgctcaat tcaggacaaa gcattcgaac    120 
               
               
                   
               
               
                 ggtcctgacg ttttgagatc caaagtggca ggaggtctgt gttgtcatgg tgaactggag    180 
               
               
                   
               
               
                 tttctcttgt gagagttccc tcatctgaaa tcatgtatct gtctcacaaa tacaagcata    240 
               
               
                   
               
               
                 agtagaagat ttgttgaaga catagaaccc ttataaagaa ttattaacct ttataaacat    300 
               
               
                   
               
               
                 ttaaagtctt gtgagcacct gggaattagt ataataacaa tgttnatatt tttgatttac    360 
               
               
                   
               
               
                 attttgtaag gctataattg tatcttttaa gaaaacatac cttggatttc tatgttgaaa    420 
               
               
                   
               
               
                 tggagatttt taagagtttt aaccagctgc tgcagatata ttactcaaaa cagatatagc    480 
               
               
                   
               
               
                 gtataaagat atagtaaatg catctcctag agtaatattc acttaacaca ttggaaacta    540 
               
               
                   
               
               
                 ttatttttta gatttgaata tnaatgttat tttttaaaca cttgttatga gttacttggg    600 
               
               
                   
               
               
                 attacatttt gaaatcagtt cattccatga tgcanattac tgggattaga ttaagaaaga    660 
               
               
                   
               
               
                 cggaaaa                                                              667 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 100 
               
               
                 &lt;211&gt; LENGTH: 583 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (404) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (506) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (514) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (527) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (528) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (538) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (548) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (556) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (568) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (569) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 100 
               
               
                   
               
               
                 gttttgtttg taagatgatc acagtcatgt tacactgatc taaaggacat atatataacc     60 
               
               
                   
               
               
                 ctttaaaaaa aaaatcactg cctcattctt atttcaagat gaatttctat acagactaga    120 
               
               
                   
               
               
                 tgtttttctg aagatcaatt agacattttg aaaatgattt aaagtgtttt ccttaatgtt    180 
               
               
                   
               
               
                 ctctgaaaac aagtttcttt tgtagtttta accaaaaaag tgcccttttt gtcactggat    240 
               
               
                   
               
               
                 tctcctagca ttcatgattt ttttttcata caatgaaatt aaaattgcta aaatcatgga    300 
               
               
                   
               
               
                 ctggctttct ggttggattt caggtaagat gtgtttaagg ccagagcttt tctcagtatt    360 
               
               
                   
               
               
                 tgattttttt ccccaatatt tgatttttta aaaatataca catnggtgct gcatttatat    420 
               
               
                   
               
               
                 ctgctggttt aaaattctgt catatttcac ttctagcctt ttagttatgg caaatcatat    480 
               
               
                   
               
               
                 tttactttta cttaaagcat ttggtnattt ggantatctg gttctannct aaaaaaanta    540 
               
               
                   
               
               
                 attctatnaa ttgaantttt ggtactcnnc catatttgga tcc                      583 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 101 
               
               
                 &lt;211&gt; LENGTH: 592 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (218) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (497) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (502) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (533) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (544) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (546) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (548) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (550) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (555) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 101 
               
               
                   
               
               
                 gtggagacgt acaaagagca gccgctcaag acacctggga agaaaaagaa aggcaagccc     60 
               
               
                   
               
               
                 gggaaacgca aggagcagga aaagaaaaaa cggcgaactc gctctgcctg gttagactct    120 
               
               
                   
               
               
                 ggagtgactg ggagtgggct agaaggggac cacctgtctg acacctccac aacgtcgctg    180 
               
               
                   
               
               
                 gagctcgatt cacggaggca ttgaaatttt cagcaganac cttccaagga catattgcag    240 
               
               
                   
               
               
                 gattctgtaa tagtgaacat atggaaagta ttagaaatat ttattgtctg taaatactgt    300 
               
               
                   
               
               
                 aaatgcattg gaataaaact gtctccccca ttgctctatg aaactgcaca ttggtcattg    360 
               
               
                   
               
               
                 tgaatatttt tttttttgcc aaggctaatc caattattat tatcacattt accataattt    420 
               
               
                   
               
               
                 attttgtcca ttgatgtatt tattttgtaa atgtatcttg gtgctgctga atttctatat    480 
               
               
                   
               
               
                 tttttgtaca taatgcnttt anatatacct atcaagtttg ttgataaatg acncaatgaa    540 
               
               
                   
               
               
                 gtgncncnan ttggnggttg aatttaatga atgcctaatt ttattatccc aa            592 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 102 
               
               
                 &lt;211&gt; LENGTH: 587 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (91) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (131) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (256) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (263) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (332) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (392) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (400) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (403) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (441) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (496) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (497) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (499) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (510) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (511) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (518) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (519) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (539) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (554) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (560) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (566) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 102 
               
               
                   
               
               
                 cgtcctaagc acttagacta catcagggaa gaacacagac cacatccctg tcctcatgcg     60 
               
               
                   
               
               
                 gcttatgttt tctggaagaa agtggagacc nagtccttgg ctttagggct ccccggctgg    120 
               
               
                   
               
               
                 gggctgtgca ntccggtcag ggcgggaagg gaaatgcacc gctgcatgtg aacttacagc    180 
               
               
                   
               
               
                 ccaggcggat gccccttccc ttagcactac ctggcctcct gcatcccctc gcctcatgtt    240 
               
               
                   
               
               
                 cctcccacct tcaaanaatg aanaacccca tgggcccagc cccttgccct ggggaaccaa    300 
               
               
                   
               
               
                 ggcagccttc caaaactcag gggctgaagc anactattag ggcaggggct gactttgggt    360 
               
               
                   
               
               
                 gacactgccc attccctctc agggcagctc angtcacccn ggnctcttga acccagcctg    420 
               
               
                   
               
               
                 ttcctttgaa aaagggcaaa actgaaaagg gcttttccta naaaaagaaa aaccagggaa    480 
               
               
                   
               
               
                 ctttgccagg gcttcnntnt taccaaaacn ncttctcnng gatttttaat tccccattng    540 
               
               
                   
               
               
                 gcctccactt accnggggcn atgccccaaa attaanaatt tcccatc                  587 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 103 
               
               
                 &lt;211&gt; LENGTH: 496 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (2) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (17) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (66) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (74) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (82) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (119) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (164) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (166) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (172) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (200) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (203) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (228) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (232) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (271) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (273) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (415) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (423) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (445) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (446) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (473) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 103 
               
               
                   
               
               
                 anaggactgg ccctacntgc tctctctcgt cctacctatc aatgcccaac atggcagaac     60 
               
               
                   
               
               
                 ctgcanccct tggncactgc anatggaaac ctctcagtgt cttgacatca ccctacccnt    120 
               
               
                   
               
               
                 gcggtgggtc tccaccacaa ccactttgac tctgtggtcc ctgnanggtg gnttctcctg    180 
               
               
                   
               
               
                 actggcagga tggaccttan ccnacatatc cctctgttcc ctctgctnag anaaagaatt    240 
               
               
                   
               
               
                 cccttaacat gatataatcc acccatgcaa ntngctactg gcccagctac catttaccat    300 
               
               
                   
               
               
                 ttgcctacag aatttcattc agtctacact ttggcattct ctctggcgat agagtgtggc    360 
               
               
                   
               
               
                 tgggctgacc gcaaaaggtg ccttacacac tggcccccac cctcaaccgt tgacncatca    420 
               
               
                   
               
               
                 gangcttgcc tcctccttct gattnncccc catgttggat atcagggtgc tcnagggatt    480 
               
               
                   
               
               
                 ggaaaagaaa caaaac                                                    496 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 104 
               
               
                 &lt;211&gt; LENGTH: 575 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (18) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (19) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (45) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (68) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (77) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (132) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (155) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (174) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (218) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (226) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (238) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (259) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (263) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (271) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (273) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (306) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (323) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (339) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (363) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (368) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (370) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (378) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (381) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (382) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (436) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (450) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (459) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (460) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (466) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (481) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (485) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (496) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (503) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (510) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (512) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (515) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (528) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (542) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (552) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 104 
               
               
                   
               
               
                 gcacctgctc tcaatccnnc tctcaccatg atcctccgcc tgcanaaact cctctgccaa     60 
               
               
                   
               
               
                 ctatggangt ggtttcnggg gtggctcttg ccaactggga agaagccgtg gtgtctctac    120 
               
               
                   
               
               
                 ctgttcaact cngtttgtgt ctgggggatc aactnggggc tatggaagcg gctnaactgt    180 
               
               
                   
               
               
                 tgttttggtg gaagggctgg taattggctt tgggaagtng cttatngaag ttggcctngg    240 
               
               
                   
               
               
                 gaagttgcta ttgaaagtng ccntggaagt ngntttggtg gggggttttg ctggtggcct    300 
               
               
                   
               
               
                 ttgttnaatt tgggtgcttt gtnaatggcg gccccctcnc ctgggcaatg aaaaaaatca    360 
               
               
                   
               
               
                 ccnatgcngn aaacctcnac nnaacagcct gggcttccct cacctcgaaa aaagttgctc    420 
               
               
                   
               
               
                 cccccccaaa aaaggncaan cccctcaann tggaangttg aaaaaatcct cgaatgggga    480 
               
               
                   
               
               
                 ncccnaaaac aaaaancccc ccntttcccn gnaanggggg aaataccncc cccccactta    540 
               
               
                   
               
               
                 cnaaaaccct tntaaaaaac cccccgggaa aaaaa                               575 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 105 
               
               
                 &lt;211&gt; LENGTH: 619 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (260) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (527) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (560) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (564) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (566) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (575) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (599) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 105 
               
               
                   
               
               
                 cactagtagg atagaaacac tgtgtcccga gagtaaggag agaagctact attgattaga     60 
               
               
                   
               
               
                 gcctaaccca ggttaactgc aagaagaggc gggatacttt cagctttcca tgtaactgta    120 
               
               
                   
               
               
                 tgcataaagc caatgtagtc cagtttctaa gatcatgttc caagctaact gaatcccact    180 
               
               
                   
               
               
                 tcaatacaca ctcatgaact cctgatggaa caataacagg cccaagcctg tggtatgatg    240 
               
               
                   
               
               
                 tgcacacttg ctagactcan aaaaaatact actctcataa atgggtggga gtattttggt    300 
               
               
                   
               
               
                 gacaacctac tttgcttggc tgagtgaagg aatgatattc atatattcat ttattccatg    360 
               
               
                   
               
               
                 gacatttagt tagtgctttt tatataccag gcatgatgct gagtgacact cttgtgtata    420 
               
               
                   
               
               
                 tttccaaatt tttgtacagt cgctgcacat atttgaaatc atatattaag acttccaaaa    480 
               
               
                   
               
               
                 aatgaagtcc ctggtttttc atggcaactt gatcagtaaa ggattcncct ctgtttggta    540 
               
               
                   
               
               
                 cttaaaacat ctactatatn gttnanatga aattcctttt ccccncctcc cgaaaaaana    600 
               
               
                   
               
               
                 aagtggtggg gaaaaaaaa                                                 619 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 106 
               
               
                 &lt;211&gt; LENGTH: 506 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (8) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (21) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (31) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (32) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (58) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (75) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (89) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (96) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (99) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (103) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (122) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (126) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (147) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (150) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (158) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (195) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (210) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (212) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (219) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (226) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (246) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (248) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (249) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (255) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (258) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (261) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (263) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (265) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (275) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (304) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (317) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (321) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (331) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (337) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (340) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (358) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (371) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (377) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (380) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (396) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (450) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (491) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 106 
               
               
                   
               
               
                 cattggtnct ttcatttgct ntggaagtgt nnatctctaa cagtggacaa agttcccngt     60 
               
               
                   
               
               
                 gccttaaact ctgtnacact tttgggaant gaaaanttng tantatgata ggttattctg    120 
               
               
                   
               
               
                 angtanagat gttctggata ccattanatn tgcccccngt gtcagaggct catattgtgt    180 
               
               
                   
               
               
                 tatgtaaatg gtatntcatt cgctactatn antcaattng aaatanggtc tttgggttat    240 
               
               
                   
               
               
                 gaatantnng cagcncanct nanangctgt ctgtngtatt cattgtggtc atagcacctc    300 
               
               
                   
               
               
                 acancattgt aacctcnatc nagtgagaca nactagnaan ttcctagtga tggctcanga    360 
               
               
                   
               
               
                 ttccaaatgg nctcatntcn aatgtttaaa agttanttaa gtgtaagaaa tacagactgg    420 
               
               
                   
               
               
                 atgttccacc aactagtacc tgtaatgacn ggcctgtccc aacacatctc ccttttccat    480 
               
               
                   
               
               
                 gactgtggta ncccgcatcg gaaaaa                                         506 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 107 
               
               
                 &lt;211&gt; LENGTH: 452 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (289) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (317) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (378) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 107 
               
               
                   
               
               
                 gttgagtctg tactaaacag taagatatct caatgaacca taaattcaac tttgtaaaaa     60 
               
               
                   
               
               
                 tcttttgaag catagataat attgtttggt aaatgtttct tttgtttggt aaatgtttct    120 
               
               
                   
               
               
                 tttaaagacc ctcctattct ataaaactct gcatgtagag gcttgtttac ctttctctct    180 
               
               
                   
               
               
                 ctaaggttta caataggagt ggtgatttga aaaatataaa attatgagat tggttttcct    240 
               
               
                   
               
               
                 gtggcataaa ttgcatcact gtatcatttt cttttttaac cggtaagant ttcagtttgt    300 
               
               
                   
               
               
                 tggaaagtaa ctgtganaac ccagtttccc gtccatctcc cttagggact acccatagaa    360 
               
               
                   
               
               
                 catgaaaagg tccccacnga agcaagaaga taagtctttc atggctgctg gttgcttaaa    420 
               
               
                   
               
               
                 ccactttaaa accaaaaaat tccccttgga aa                                  452 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 108 
               
               
                 &lt;211&gt; LENGTH: 502 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (22) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (31) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (126) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (168) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (183) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (205) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (219) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (231) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (236) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (259) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (283) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (295) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (296) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (298) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (301) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (340) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (354) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (378) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (383) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (409) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (433) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (446) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (455) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (466) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (488) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 108 
               
               
                   
               
               
                 atcttcttcc cttaattagt tnttatttat ntattaaatt ttattgcatg tcctggcaaa     60 
               
               
                   
               
               
                 caaaaagaga ttgtagattg gcttctggct ccccaaaagc ccataacaga aagtaccaca    120 
               
               
                   
               
               
                 agaccncaac tgaagcttaa aaaatctatc acatgtataa tacctttnga agaacattaa    180 
               
               
                   
               
               
                 tanagcatat aaaactttta acatntgctt aatgttgtnc aattataaaa ntaatngaaa    240 
               
               
                   
               
               
                 aaaatgtccc tttaacatnc aatatcccac atagtgttat ttnaggggat taccnngnaa    300 
               
               
                   
               
               
                 naaaaaaagg gtagaaggga tttaatgaaa actctgcttn ccatttctgt ttanaaacgt    360 
               
               
                   
               
               
                 ctccagaaca aaaacttntc aantctttca gctaaccgca tttgagctna ggccactcaa    420 
               
               
                   
               
               
                 aaactccatt agncccactt tctaanggtc tctanagctt actaancctt ttgacccctt    480 
               
               
                   
               
               
                 accctggnta ctcctgccct ca                                             502 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 109 
               
               
                 &lt;211&gt; LENGTH: 1308 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 109 
               
               
                   
               
               
                 acccgaggtc tcgctaaaat catcatggat tcacttggcg ccgtcagcac tcgacttggg     60 
               
               
                   
               
               
                 tttgatcttt tcaaagagct gaagaaaaca aatgatggca acatcttctt ttcccctgtg    120 
               
               
                   
               
               
                 ggcatcttga ctgcaattgg catggtcctc ctggggaccc gaggagccac cgcttcccag    180 
               
               
                   
               
               
                 ttggaggagg tgtttcactc tgaaaaagag acgaagagct caagaataaa ggctgaagaa    240 
               
               
                   
               
               
                 aaagaggtga ttgagaacac agaagcagta catcaacaat tccaaaagtt tttgactgaa    300 
               
               
                   
               
               
                 ataagcaaac tcactaatga ttatgaactg aacataacca acaggctgtt tggagaaaaa    360 
               
               
                   
               
               
                 acatacctct tccttcaaaa atacttagat tatgttgaaa aatattatca tgcatctctg    420 
               
               
                   
               
               
                 gaacctgttg attttgtaaa tgcagccgat gaaagtcgaa agaagattaa ttcctgggtt    480 
               
               
                   
               
               
                 gaaagcaaaa caaatgaaaa aatcaaggac ttgttcccag atggctctat tagtagctct    540 
               
               
                   
               
               
                 accaagctgg tgctggtgaa catggtttat tttaaagggc aatgggacag ggagtttaag    600 
               
               
                   
               
               
                 aaagaaaata ctaaggaaga gaaattttgg atgaataaga gcacaagtaa atctgtacag    660 
               
               
                   
               
               
                 atgatgacac agagccattc ctttagcttc actttcctgg aggacttgca ggccaaaatt    720 
               
               
                   
               
               
                 ctagggattc catataaaaa caacgaccta agcatgtttg tgcttctgcc caacgacatc    780 
               
               
                   
               
               
                 gatggcctgg agaagataat agataaaata agtcctgaga aattggtaga gtggactagt    840 
               
               
                   
               
               
                 ccagggcata tggaagaaag aaaggtgaat ctgcacttgc cccggtttga ggtggaggac    900 
               
               
                   
               
               
                 agttacgatc tagaggcggt cctggctgcc atggggatgg gcgatgcctt cagtgagcac    960 
               
               
                   
               
               
                 aaagccgact actcgggaat gtcgtcaggc tccgggttgt acgcccagaa gttcctgcac   1020 
               
               
                   
               
               
                 agttcctttg tggcagtaac tgaggaaggc accgaggctg cagctgccac tggcataggc   1080 
               
               
                   
               
               
                 tttactgtca catccgcccc aggtcatgaa aatgttcact gcaatcatcc cttcctgttc   1140 
               
               
                   
               
               
                 ttcatcaggc acaatgaatc caacagcatc ctcttcttcg gcagattttc ttctccttaa   1200 
               
               
                   
               
               
                 gatgatcgtt gccatggcat tgctgctttt agcaaaaaac aactaccagt gttactcata   1260 
               
               
                   
               
               
                 tgattatgaa aatcgtccat tcttttaaat ggtggctcac ttgcattt                1308 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 110 
               
               
                 &lt;211&gt; LENGTH: 391 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 110 
               
               
                   
               
               
                 Met Asp Ser Leu Gly Ala Val Ser Thr Arg Leu Gly Phe Asp Leu Phe 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Lys Glu Leu Lys Lys Thr Asn Asp Gly Asn Ile Phe Phe Ser Pro Val 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Gly Ile Leu Thr Ala Ile Gly Met Val Leu Leu Gly Thr Arg Gly Ala 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Thr Ala Ser Gln Leu Glu Glu Val Phe His Ser Glu Lys Glu Thr Lys 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ser Ser Arg Ile Lys Ala Glu Glu Lys Glu Val Ile Glu Asn Thr Glu 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Ala Val His Gln Gln Phe Gln Lys Phe Leu Thr Glu Ile Ser Lys Leu 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Thr Asn Asp Tyr Glu Leu Asn Ile Thr Asn Arg Leu Phe Gly Glu Lys 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Thr Tyr Leu Phe Leu Gln Lys Tyr Leu Asp Tyr Val Glu Lys Tyr Tyr 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 His Ala Ser Leu Glu Pro Val Asp Phe Val Asn Ala Ala Asp Glu Ser 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Arg Lys Lys Ile Asn Ser Trp Val Glu Ser Lys Thr Asn Glu Lys Ile 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Lys Asp Leu Phe Pro Asp Gly Ser Ile Ser Ser Ser Thr Lys Leu Val 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Leu Val Asn Met Val Tyr Phe Lys Gly Gln Trp Asp Arg Glu Phe Lys 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Lys Glu Asn Thr Lys Glu Glu Lys Phe Trp Met Asn Lys Ser Thr Ser 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Lys Ser Val Gln Met Met Thr Gln Ser His Ser Phe Ser Phe Thr Phe 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Leu Glu Asp Leu Gln Ala Lys Ile Leu Gly Ile Pro Tyr Lys Asn Asn 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Asp Leu Ser Met Phe Val Leu Leu Pro Asn Asp Ile Asp Gly Leu Glu 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Lys Ile Ile Asp Lys Ile Ser Pro Glu Lys Leu Val Glu Trp Thr Ser 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Pro Gly His Met Glu Glu Arg Lys Val Asn Leu His Leu Pro Arg Phe 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Glu Val Glu Asp Ser Tyr Asp Leu Glu Ala Val Leu Ala Ala Met Gly 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Met Gly Asp Ala Phe Ser Glu His Lys Ala Asp Tyr Ser Gly Met Ser 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 Ser Gly Ser Gly Leu Tyr Ala Gln Lys Phe Leu His Ser Ser Phe Val 
               
               
                                 325                 330                 335 
               
               
                   
               
               
                 Ala Val Thr Glu Glu Gly Thr Glu Ala Ala Ala Ala Thr Gly Ile Gly 
               
               
                             340                 345                 350 
               
               
                   
               
               
                 Phe Thr Val Thr Ser Ala Pro Gly His Glu Asn Val His Cys Asn His 
               
               
                         355                 360                 365 
               
               
                   
               
               
                 Pro Phe Leu Phe Phe Ile Arg His Asn Glu Ser Asn Ser Ile Leu Phe 
               
               
                     370                 375                 380 
               
               
                   
               
               
                 Phe Gly Arg Phe Ser Ser Pro 
               
               
                 385                 390 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 111 
               
               
                 &lt;211&gt; LENGTH: 1419 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 111 
               
               
                   
               
               
                 ggagaactat aaattaagga tcccagctac ttaattgact tatgcttcct agttcgttgc     60 
               
               
                   
               
               
                 ccagccacca ccgtctctcc aaaaacccga ggtctcgcta aaatcatcat ggattcactt    120 
               
               
                   
               
               
                 ggcgccgtca gcactcgact tgggtttgat cttttcaaag agctgaagaa aacaaatgat    180 
               
               
                   
               
               
                 ggcaacatct tcttttcccc tgtgggcatc ttgactgcaa ttggcatggt cctcctgggg    240 
               
               
                   
               
               
                 acccgaggag ccaccgcttc ccagttggag gaggtgtttc actctgaaaa agagacgaag    300 
               
               
                   
               
               
                 agctcaagaa taaaggctga agaaaaagag gtggtaagaa taaaggctga aggaaaagag    360 
               
               
                   
               
               
                 attgagaaca cagaagcagt acatcaacaa ttccaaaagt ttttgactga aataagcaaa    420 
               
               
                   
               
               
                 ctcactaatg attatgaact gaacataacc aacaggctgt ttggagaaaa aacatacctc    480 
               
               
                   
               
               
                 ttccttcaaa aatacttaga ttatgttgaa aaatattatc atgcatctct ggaacctgtt    540 
               
               
                   
               
               
                 gattttgtaa atgcagccga tgaaagtcga aagaagatta attcctgggt tgaaagcaaa    600 
               
               
                   
               
               
                 acaaatgaaa aaatcaagga cttgttccca gatggctcta ttagtagctc taccaagctg    660 
               
               
                   
               
               
                 gtgctggtga acatggttta ttttaaaggg caatgggaca gggagtttaa gaaagaaaat    720 
               
               
                   
               
               
                 actaaggaag agaaattttg gatgaataag agcacaagta aatctgtaca gatgatgaca    780 
               
               
                   
               
               
                 cagagccatt cctttagctt cactttcctg gaggacttgc aggccaaaat tctagggatt    840 
               
               
                   
               
               
                 ccatataaaa acaacgacct aagcatgttt gtgcttctgc ccaacgacat cgatggcctg    900 
               
               
                   
               
               
                 gagaagataa tagataaaat aagtcctgag aaattggtag agtggactag tccagggcat    960 
               
               
                   
               
               
                 atggaagaaa gaaaggtgaa tctgcacttg ccccggtttg aggtggagga cagttacgat   1020 
               
               
                   
               
               
                 ctagaggcgg tcctggctgc catggggatg ggcgatgcct tcagtgagca caaagccgac   1080 
               
               
                   
               
               
                 tactcgggaa tgtcgtcagg ctccgggttg tacgcccaga agttcctgca cagttccttt   1140 
               
               
                   
               
               
                 gtggcagtaa ctgaggaagg caccgaggct gcagctgcca ctggcatagg ctttactgtc   1200 
               
               
                   
               
               
                 acatccgccc caggtcatga aaatgttcac tgcaatcatc ccttcctgtt cttcatcagg   1260 
               
               
                   
               
               
                 cacaatgaat ccaacagcat cctcttcttc ggcagatttt cttctcctta agatgatcgt   1320 
               
               
                   
               
               
                 tgccatggca ttgctgcttt tagcaaaaaa caactaccag tgttactcat atgattatga   1380 
               
               
                   
               
               
                 aaatcgtcca ttcttttaaa tggtggctca cttgcattt                          1419 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 112 
               
               
                 &lt;211&gt; LENGTH: 400 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 112 
               
               
                   
               
               
                 Met Asp Ser Leu Gly Ala Val Ser Thr Arg Leu Gly Phe Asp Leu Phe 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Lys Glu Leu Lys Lys Thr Asn Asp Gly Asn Ile Phe Phe Ser Pro Val 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Gly Ile Leu Thr Ala Ile Gly Met Val Leu Leu Gly Thr Arg Gly Ala 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Thr Ala Ser Gln Leu Glu Glu Val Phe His Ser Glu Lys Glu Thr Lys 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Ser Ser Arg Ile Lys Ala Glu Glu Lys Glu Val Val Arg Ile Lys Ala 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Glu Gly Lys Glu Ile Glu Asn Thr Glu Ala Val His Gln Gln Phe Gln 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Lys Phe Leu Thr Glu Ile Ser Lys Leu Thr Asn Asp Tyr Glu Leu Asn 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Ile Thr Asn Arg Leu Phe Gly Glu Lys Thr Tyr Leu Phe Leu Gln Lys 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Tyr Leu Asp Tyr Val Glu Lys Tyr Tyr His Ala Ser Leu Glu Pro Val 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Asp Phe Val Asn Ala Ala Asp Glu Ser Arg Lys Lys Ile Asn Ser Trp 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Val Glu Ser Lys Thr Asn Glu Lys Ile Lys Asp Leu Phe Pro Asp Gly 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Ser Ile Ser Ser Ser Thr Lys Leu Val Leu Val Asn Met Val Tyr Phe 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Lys Gly Gln Trp Asp Arg Glu Phe Lys Lys Glu Asn Thr Lys Glu Glu 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Lys Phe Trp Met Asn Lys Ser Thr Ser Lys Ser Val Gln Met Met Thr 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Gln Ser His Ser Phe Ser Phe Thr Phe Leu Glu Asp Leu Gln Ala Lys 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Ile Leu Gly Ile Pro Tyr Lys Asn Asn Asp Leu Ser Met Phe Val Leu 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Leu Pro Asn Asp Ile Asp Gly Leu Glu Lys Ile Ile Asp Lys Ile Ser 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Pro Glu Lys Leu Val Glu Trp Thr Ser Pro Gly His Met Glu Glu Arg 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Lys Val Asn Leu His Leu Pro Arg Phe Glu Val Glu Asp Ser Tyr Asp 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Leu Glu Ala Val Leu Ala Ala Met Gly Met Gly Asp Ala Phe Ser Glu 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 His Lys Ala Asp Tyr Ser Gly Met Ser Ser Gly Ser Gly Leu Tyr Ala 
               
               
                                 325                 330                 335 
               
               
                   
               
               
                 Gln Lys Phe Leu His Ser Ser Phe Val Ala Val Thr Glu Glu Gly Thr 
               
               
                             340                 345                 350 
               
               
                   
               
               
                 Glu Ala Ala Ala Ala Thr Gly Ile Gly Phe Thr Val Thr Ser Ala Pro 
               
               
                         355                 360                 365 
               
               
                   
               
               
                 Gly His Glu Asn Val His Cys Asn His Pro Phe Leu Phe Phe Ile Arg 
               
               
                     370                 375                 380 
               
               
                   
               
               
                 His Asn Glu Ser Asn Ser Ile Leu Phe Phe Gly Arg Phe Ser Ser Pro 
               
               
                 385                 390                 395                 400 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 113 
               
               
                 &lt;211&gt; LENGTH: 957 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 113 
               
               
                   
               
               
                 ctcgaccttc tctgcacagc ggatgaaccc tgagcagctg aagaccagaa aagccactat     60 
               
               
                   
               
               
                 gactttctgc ttaattcagg agcttacagg attcttcaaa gagtgtgtcc agcatccttt    120 
               
               
                   
               
               
                 gaaacatgag ttcttaccag cagaagcaga cctttacccc accacctcag cttcaacagc    180 
               
               
                   
               
               
                 agcaggtgaa acaacccagc cagcctccac ctcaggaaat atttgttccc acaaccaagg    240 
               
               
                   
               
               
                 agccatgcca ctcaaaggtt ccacaacctg gaaacacaaa gattccagag ccaggctgta    300 
               
               
                   
               
               
                 ccaaggtccc tgagccaggc tgtaccaagg tccctgagcc aggttgtacc aaggtccctg    360 
               
               
                   
               
               
                 agccaggatg taccaaggtc cctgagccag gttgtaccaa ggtccctgag ccaggctaca    420 
               
               
                   
               
               
                 ccaaggtccc tgagccaggc agcatcaagg tccctgacca aggcttcatc aagtttcctg    480 
               
               
                   
               
               
                 agccaggtgc catcaaagtt cctgagcaag gatacaccaa agttcctgtg ccaggctaca    540 
               
               
                   
               
               
                 caaaggtacc agagccatgt ccttcaacgg tcactccagg cccagctcag cagaagacca    600 
               
               
                   
               
               
                 agcagaagta atttggtgca cagacaagcc cttgagaagc caaccaccag atgctggaca    660 
               
               
                   
               
               
                 ccctcttccc atctgtttct gtgtcttaat tgtctgtaga ccttgtaatc agtacattct    720 
               
               
                   
               
               
                 caccccaagc catagtctct ctcttatttg tatcctaaaa atacggtact ataaagcttt    780 
               
               
                   
               
               
                 tgttcacaca cactctgaag aatcctgtaa gcccctgaat taagcagaaa gtcttcatgg    840 
               
               
                   
               
               
                 cttttctggt cttcggctgc tcagggttca tctgaagatt cgaatgaaaa gaaatgcatg    900 
               
               
                   
               
               
                 tttcctgctc tgccctcatt aaattgcttt taattccaaa aaaaaaaaaa aaaaaaa       957 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 114 
               
               
                 &lt;211&gt; LENGTH: 161 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Homo sapiens 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 114 
               
               
                   
               
               
                 Met Ser Ser Tyr Gln Gln Lys Gln Thr Phe Thr Pro Pro Pro Gln Leu 
               
               
                   1               5                  10                  15 
               
               
                   
               
               
                 Gln Gln Gln Gln Val Lys Gln Pro Ser Gln Pro Pro Pro Gln Glu Ile 
               
               
                              20                  25                  30 
               
               
                   
               
               
                 Phe Val Pro Thr Thr Lys Glu Pro Cys His Ser Lys Val Pro Gln Pro 
               
               
                          35                  40                  45 
               
               
                   
               
               
                 Gly Asn Thr Lys Ile Pro Glu Pro Gly Cys Thr Lys Val Pro Glu Pro 
               
               
                      50                  55                  60 
               
               
                   
               
               
                 Gly Cys Thr Lys Val Pro Glu Pro Gly Cys Thr Lys Val Pro Glu Pro 
               
               
                  65                  70                  75                  80 
               
               
                   
               
               
                 Gly Cys Thr Lys Val Pro Glu Pro Gly Cys Thr Lys Val Pro Glu Pro 
               
               
                                  85                  90                  95 
               
               
                   
               
               
                 Gly Tyr Thr Lys Val Pro Glu Pro Gly Ser Ile Lys Val Pro Asp Gln 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Gly Phe Ile Lys Phe Pro Glu Pro Gly Ala Ile Lys Val Pro Glu Gln 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Gly Tyr Thr Lys Val Pro Val Pro Gly Tyr Thr Lys Val Pro Glu Pro 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Cys Pro Ser Thr Val Thr Pro Gly Pro Ala Gln Gln Lys Thr Lys Gln 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Lys 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 115 
               
               
                 &lt;211&gt; LENGTH: 506 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (8) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (21) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (31) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (32) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (58) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (75) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (89) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (96) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (99) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (103) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (122) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (126) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (147) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (150) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (158) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (195) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (210) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (212) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (219) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (226) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (246) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (248) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (249) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (255) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (258) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (261) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (263) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (265) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (275) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (304) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (317) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (321) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (331) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (337) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (340) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (358) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (371) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (377) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (380) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (396) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (450) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (491) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 115 
               
               
                   
               
               
                 cattggtnct ttcatttgct ntggaagtgt nnatctctaa cagtggacaa agttcccngt     60 
               
               
                   
               
               
                 gccttaaact ctgtnacact tttgggaant gaaaanttng tantatgata ggttattctg    120 
               
               
                   
               
               
                 angtanagat gttctggata ccattanatn tgcccccngt gtcagaggct catattgtgt    180 
               
               
                   
               
               
                 tatgtaaatg gtatntcatt cgctactatn antcaattng aaatanggtc tttgggttat    240 
               
               
                   
               
               
                 gaatantnng cagcncanct nanangctgt ctgtngtatt cattgtggtc atagcacctc    300 
               
               
                   
               
               
                 acancattgt aacctcnatc nagtgagaca nactagnaan ttcctagtga tggctcanga    360 
               
               
                   
               
               
                 ttccaaatgg nctcatntcn aatgtttaaa agttanttaa gtgtaagaaa tacagactgg    420 
               
               
                   
               
               
                 atgttccacc aactagtacc tgtaatgacn ggcctgtccc aacacatctc ccttttccat    480 
               
               
                   
               
               
                 gactgtggta ncccgcatcg gaaaaa                                         506 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 116 
               
               
                 &lt;211&gt; LENGTH: 3079 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 116 
               
               
                   
               
               
                 ggatccccgg gtttcctaaa ccccccacag agtcctgccc aggccaaaga gcaaggaaaa     60 
               
               
                   
               
               
                 ggtcaaaggg cagaaaaaat gctgagttag gaggagctat ggaaggataa acctggcctt    120 
               
               
                   
               
               
                 aaagaggtca aagtggttta tagggggcgc tgagggcttc ccacattctc tggcctaaac    180 
               
               
                   
               
               
                 cttgcaggca gatctgccca gtgggctctg ggatagctgt gccttcccta acaaaaaaat    240 
               
               
                   
               
               
                 tgtgcacaaa aggatgaaac tctattttcc ctctagcaca taaccaagaa tataaggcta    300 
               
               
                   
               
               
                 cagattgcct ttcccagagg gaaaaccctg cagcaacctg ctgcctggaa aagtgtaaga    360 
               
               
                   
               
               
                 gcagatcact ggggaatcgt ttgccccccg ctgatggaca gcttccccaa gctccaaggg    420 
               
               
                   
               
               
                 caggtgctca gcatgtaccg tactgggatg gttgtcaata ctcctggtcc tgtaagagtc    480 
               
               
                   
               
               
                 ccaggacact gccatgccaa tgccccctca gttcctggca tcctttttgg gctgctcaca    540 
               
               
                   
               
               
                 gccccagcct ctatggtgaa gacatacttg ctagcagcgt caccaacttg ttgccaagag    600 
               
               
                   
               
               
                 atcagtgctc gaaggcaagg ttatttctaa ctgagcagag cctgccagga agaaagcgtt    660 
               
               
                   
               
               
                 tgcaccccac accactgtgc aggtgtgacc ggtgagctca cagctgcccc ccaggcatgc    720 
               
               
                   
               
               
                 ccagcccact taatcatcac agctcgacag ctctctcgcc cagcccagtt ctggaaggga    780 
               
               
                   
               
               
                 taaaaagggg catcaccgtt cctgggtaac agagccacct tctgcgtcct gctgagctct    840 
               
               
                   
               
               
                 gttctctcca gcacctccca acccactagt gcctggttct cttgctccac caggaacaag    900 
               
               
                   
               
               
                 ccaccatgtc tcgccagtca agtgtgtctt ccggagcggg gggcagtcgt agcttcagca    960 
               
               
                   
               
               
                 ccgcctctgc catcaccccg tctgtctccc gcaccagctt cacctccgtg tcccggtccg   1020 
               
               
                   
               
               
                 ggggtggcgg tggtggtggc ttcggcaggg tcagccttgc gggtgcttgt ggagtgggtg   1080 
               
               
                   
               
               
                 gctatggcag ccggagcctc tacaacctgg ggggctccaa gaggatatcc atcagcacta   1140 
               
               
                   
               
               
                 gtggtggcag cttcaggaac cggtttggtg ctggtgctgg aggcggctat ggctttggag   1200 
               
               
                   
               
               
                 gtggtgccgg tagtggattt ggtttcggcg gtggagctgg tggtggcttt gggctcggtg   1260 
               
               
                   
               
               
                 gcggagctgg ctttggaggt ggcttcggtg gccctggctt tcctgtctgc cctcctggag   1320 
               
               
                   
               
               
                 gtatccaaga ggtcactgtc aaccagagtc tcctgactcc cctcaacctg caaatcgacc   1380 
               
               
                   
               
               
                 ccagcatcca gagggtgagg accgaggagc gcgagcagat caagaccctc aacaataagt   1440 
               
               
                   
               
               
                 ttgcctcctt catcgacaag gtgcggttcc tggagcagca gaacaaggtt ctggaaacaa   1500 
               
               
                   
               
               
                 agtggaccct gctgcaggag cagggcacca agactgtgag gcagaacctg gagccgttgt   1560 
               
               
                   
               
               
                 tcgagcagta catcaacaac ctcaggaggc agctggacag catcgtgggg gaacggggcc   1620 
               
               
                   
               
               
                 gcctggactc agagctgaga aacatgcagg acctggtgga agacttcaag aacaagtatg   1680 
               
               
                   
               
               
                 aggatgaaat caacaagcgt accactgctg agaatgagtt tgtgatgctg aagaaggatg   1740 
               
               
                   
               
               
                 tagatgctgc ctacatgaac aaggtggagc tggaggccaa ggttgatgca ctgatggatg   1800 
               
               
                   
               
               
                 agattaactt catgaagatg ttctttgatg cggagctgtc ccagatgcag acgcatgtct   1860 
               
               
                   
               
               
                 ctgacacctc agtggtcctc tccatggaca acaaccgcaa cctggacctg gatagcatca   1920 
               
               
                   
               
               
                 tcgctgaggt caaggcccag tatgaggaga ttgccaaccg cagccggaca gaagccgagt   1980 
               
               
                   
               
               
                 cctggtatca gaccaagtat gaggagctgc agcagacagc tggccggcat ggcgatgacc   2040 
               
               
                   
               
               
                 tccgcaacac caagcatgag atctctgaga tgaaccggat gatccagagg ctgagagccg   2100 
               
               
                   
               
               
                 agattgacaa tgtcaagaaa cagtgcgcca atctgcagaa cgccattgcg gatgccgagc   2160 
               
               
                   
               
               
                 agcgtgggga gctggccctc aaggatgcca ggaacaagct ggccgagctg gaggaggccc   2220 
               
               
                   
               
               
                 tgcagaaggc caagcaggac atggcccggc tgctgcgtga gtaccaggag ctcatgaaca   2280 
               
               
                   
               
               
                 ccaagctggc cctggacgtg gagatcgcca cttaccgcaa gctgctggag ggcgaggaat   2340 
               
               
                   
               
               
                 gcagactcag tggagaagga gttggaccag tcaacatctc tgttgtcaca agcagtgttt   2400 
               
               
                   
               
               
                 cctctggata tggcagtggc agtggctatg gcggtggcct cggtggaggt cttggcggcg   2460 
               
               
                   
               
               
                 gcctcggtgg aggtcttgcc ggaggtagca gtggaagcta ctactccagc agcagtgggg   2520 
               
               
                   
               
               
                 gtgtcggcct aggtggtggg ctcagtgtgg ggggctctgg cttcagtgca agcagtagcc   2580 
               
               
                   
               
               
                 gagggctggg ggtgggcttt ggcagtggcg ggggtagcag ctccagcgtc aaatttgtct   2640 
               
               
                   
               
               
                 ccaccacctc ctcctcccgg aagagcttca agagctaaga acctgctgca agtcactgcc   2700 
               
               
                   
               
               
                 ttccaagtgc agcaacccag cccatggaga ttgcctcttc taggcagttg ctcaagccat   2760 
               
               
                   
               
               
                 gttttatcct tttctggaga gtagtctaga ccaagccaat tgcagaacca cattctttgg   2820 
               
               
                   
               
               
                 ttcccaggag agccccattc ccagcccctg gtctcccgtg ccgcagttct atattctgct   2880 
               
               
                   
               
               
                 tcaaatcagc cttcaggttt cccacagcat ggcccctgct gacacgagaa cccaaagttt   2940 
               
               
                   
               
               
                 tcccaaatct aaatcatcaa aacagaatcc ccaccccaat cccaaatttt gttttggttc   3000 
               
               
                   
               
               
                 taactacctc cagaatgtgt tcaataaaat gttttataat ataagctggt gtgcagaatt   3060 
               
               
                   
               
               
                 gttttttttt tctacccaa                                                3079 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 117 
               
               
                 &lt;211&gt; LENGTH: 6921 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 117 
               
               
                   
               
               
                 gaattctgac tgtccactca aaacttctat tccgatcaaa gctatctgtg actacagaca     60 
               
               
                   
               
               
                 aattgagata accatttaca aagacgatga atgtgttttg gcgaataact ctcatcgtgc    120 
               
               
                   
               
               
                 taaatggaag gtcattagtc ctactgggaa tgaggctatg gtcccatctg tgtgcttcac    180 
               
               
                   
               
               
                 cgttcctcca ccaaacaaag aagcggtgga ccttgccaac agaattgagc aacagtatca    240 
               
               
                   
               
               
                 gaatgtcctg actctttggc atgagtctca cataaacatg aagagtgtag tatcctggca    300 
               
               
                   
               
               
                 ttatctcatc aatgaaattg atagaattcg agctagcaat gtggcttcaa taaagacaat    360 
               
               
                   
               
               
                 gctacctggt gaacatcagc aagttctaag taatctacaa tctcgttttg aagattttct    420 
               
               
                   
               
               
                 ggaagatagc caggaatccc aagtcttttc aggctcagat ataacacaac tggaaaagga    480 
               
               
                   
               
               
                 ggttaatgta tgtaagcagt attatcaaga acttcttaaa tctgcagaaa gagaggagca    540 
               
               
                   
               
               
                 agaggaatca gtttataatc tctacatctc tgaagttcga aacattagac ttcggttaga    600 
               
               
                   
               
               
                 gaactgtgaa gatcggctga ttagacagat tcgaactccc ctggaaagag atgatttgca    660 
               
               
                   
               
               
                 tgaaagtgtg ttcagaatca cagaacagga gaaactaaag aaagagctgg aacgacttaa    720 
               
               
                   
               
               
                 agatgatttg ggaacaatca caaataagtg tgaggagttt ttcagtcaag cagcagcctc    780 
               
               
                   
               
               
                 ttcatcagtc cctaccctac gatcagagct taatgtggtc cttcagaaca tgaaccaagt    840 
               
               
                   
               
               
                 ctattctatg tcttccactt acatagataa gttgaaaact gttaacttgg tgttaaaaaa    900 
               
               
                   
               
               
                 cactcaagct gcagaagccc tcgtaaaact ctatgaaact aaactgtgtg aagaagaagc    960 
               
               
                   
               
               
                 agttatagct gacaagaata atattgagaa tctaataagt actttaaagc aatggagatc   1020 
               
               
                   
               
               
                 tgaagtagat gaaaagagac aggtattcca tgccttagag gatgagttgc agaaagctaa   1080 
               
               
                   
               
               
                 agccatcagt gatgaaatgt ttaaaacgta taaagaacgg gaccttgatt ttgactggca   1140 
               
               
                   
               
               
                 caaagaaaaa gcagatcaat tagttgaaag gtggcaaaat gttcatgtgc agattgacaa   1200 
               
               
                   
               
               
                 caggttacgg gacttagagg gcattggcaa atcactgaag tactacagag acacttacca   1260 
               
               
                   
               
               
                 tcctttagat gattggatcc agcaggttga aactactcag agaaagattc aggaaaatca   1320 
               
               
                   
               
               
                 gcctgaaaat agtaaaaccc tagccacaca gttgaatcaa cagaagatgc tggtgtccga   1380 
               
               
                   
               
               
                 aatagaaatg aaacagagca aaatggacga gtgtcaaaaa tatgcagaac agtactcagc   1440 
               
               
                   
               
               
                 tacagtgaag gactatgaat tacaaacaat gacctaccgg gccatggtag attcacaaca   1500 
               
               
                   
               
               
                 aaaatctcca gtgaaacgcc gaagaatgca gagttcagca gatctcatta ttcaagagtt   1560 
               
               
                   
               
               
                 catggaccta aggactcgat atactgccct ggtcactctc atgacacaat atattaaatt   1620 
               
               
                   
               
               
                 tgctggtgat tcattgaaga ggctggaaga ggaggagatt aaaaggtgta aggagacttc   1680 
               
               
                   
               
               
                 tgaacatggg gcatattcag atctgcttca gcgtcagaag gcaacagtgc ttgagaatag   1740 
               
               
                   
               
               
                 caaacttaca ggaaagataa gtgagttgga aagaatggta gctgaactaa agaaacaaaa   1800 
               
               
                   
               
               
                 gtcccgagta gaggaagaac ttccgaaggt cagggaggct gcagaaaatg aattgagaaa   1860 
               
               
                   
               
               
                 gcagcagaga aatgtagaag atatctctct gcagaagata agggctgaaa gtgaagccaa   1920 
               
               
                   
               
               
                 gcagtaccgc agggaacttg aaaccattgt gagagagaag gaagccgctg aaagagaact   1980 
               
               
                   
               
               
                 ggagcgggtg aggcagctca ccatagaggc cgaggctaaa agagctgccg tggaagagaa   2040 
               
               
                   
               
               
                 cctcctgaat tttcgcaatc agttggagga aaacaccttt accagacgaa cactggaaga   2100 
               
               
                   
               
               
                 tcatcttaaa agaaaagatt taagtctcaa tgatttggag caacaaaaaa ataaattaat   2160 
               
               
                   
               
               
                 ggaagaatta agaagaaaga gagacaatga ggaagaactc ttgaagctga taaagcagat   2220 
               
               
                   
               
               
                 ggaaaaagac cttgcatttc agaaacaggt agcagagaaa cagttgaaag aaaagcagaa   2280 
               
               
                   
               
               
                 aattgaattg gaagcaagaa gaaaaataac tgaaattcag tatacatgta gagaaaatgc   2340 
               
               
                   
               
               
                 attgccagtg tgtccgatca cacaggctac atcatgcagg gcagtaacgg gtctccagca   2400 
               
               
                   
               
               
                 agaacatgac aagcagaaag cagaagaact caaacagcag gtagatgaac taacagctgc   2460 
               
               
                   
               
               
                 caatagaaag gctgaacaag acatgagaga gctgacatat gaacttaatg ccctccagct   2520 
               
               
                   
               
               
                 tgaaaaaacg tcatctgagg aaaaggctcg tttgctaaaa gataaactag atgaaacaaa   2580 
               
               
                   
               
               
                 taatacactc agatgcctta agttggagct ggaaaggaag gatcaggcgg agaaagggta   2640 
               
               
                   
               
               
                 ttctcaacaa ctcagagagc ttggtaggca attgaatcaa accacaggta aagctgaaga   2700 
               
               
                   
               
               
                 agccatgcaa gaagctagtg atctcaagaa aataaagcgc aattatcagt tagaattaga   2760 
               
               
                   
               
               
                 atctcttaat catgaaaaag ggaaactaca aagagaagta gacagaatca caagggcaca   2820 
               
               
                   
               
               
                 tgctgtagct gagaagaata ttcagcattt aaattcacaa attcattctt ttcgagatga   2880 
               
               
                   
               
               
                 gaaagaatta gaaagactac aaatctgcca gagaaaatca gatcatctaa aagaacaatt   2940 
               
               
                   
               
               
                 tgagaaaagc catgagcagt tgcttcaaaa tatcaaagct gaaaaagaaa ataatgataa   3000 
               
               
                   
               
               
                 aatccaaagg ctcaatgaag aattggagaa aagtaatgag tgtgcagaga tgctaaaaca   3060 
               
               
                   
               
               
                 aaaagtagag gagcttacta ggcagaataa tgaaaccaaa ttaatgatgc agagaattca   3120 
               
               
                   
               
               
                 ggcagaatca gagaatatag ttttagagaa acaaactatc cagcaaagat gtgaagcact   3180 
               
               
                   
               
               
                 gaaaattcag gcagatggtt ttaaagatca gctacgcagc acaaatgaac acttgcataa   3240 
               
               
                   
               
               
                 acagacaaaa acagagcagg attttcaaag aaaaattaaa tgcctagaag aagacctggc   3300 
               
               
                   
               
               
                 gaaaagtcaa aatttggtaa gtgaatttaa gcaaaagtgt gaccaacaga acattatcat   3360 
               
               
                   
               
               
                 ccagaatacc aagaaagaag ttagaaatct gaatgcggaa ctgaatgctt ccaaagaaga   3420 
               
               
                   
               
               
                 gaagcgacgc ggggagcaga aagttcagct acaacaagct caggtgcaag agttaaataa   3480 
               
               
                   
               
               
                 caggttgaaa aaagtacaag acgaattaca cttaaagacc atagaggagc agatgaccca   3540 
               
               
                   
               
               
                 cagaaagatg gttctgtttc aggaagaatc tggtaaattc aaacaatcag cagaggagtt   3600 
               
               
                   
               
               
                 tcggaagaag atggaaaaat taatggagtc caaagtcatc actgaaaatg atatttcagg   3660 
               
               
                   
               
               
                 cattaggctt gactttgtgt ctcttcaaca agaaaactct agagcccaag aaaatgctaa   3720 
               
               
                   
               
               
                 gctttgtgaa acaaacatta aagaacttga aagacagctt caacagtatc gtgaacaaat   3780 
               
               
                   
               
               
                 gcagcaaggg cagcacatgg aagcaaatca ttaccaaaaa tgtcagaaac ttgaggatga   3840 
               
               
                   
               
               
                 gctgatagcc cagaagcgtg aggttgaaaa cctgaagcaa aaaatggacc aacagatcaa   3900 
               
               
                   
               
               
                 agagcatgaa catcaattag ttttgctcca gtgtgaaatt caaaaaaaga gcacagccaa   3960 
               
               
                   
               
               
                 agactgtacc ttcaaaccag attttgagat gacagtgaag gagtgccagc actctggaga   4020 
               
               
                   
               
               
                 gctgtcctct agaaacactg gacaccttca cccaacaccc agatcccctc tgttgagatg   4080 
               
               
                   
               
               
                 gactcaagaa ccacagccat tggaagagaa gtggcagcat cgggttgttg aacagatacc   4140 
               
               
                   
               
               
                 caaagaagtc caattccagc caccaggggc tccactcgag aaagagaaaa gccagcagtg   4200 
               
               
                   
               
               
                 ttactctgag tacttttctc agacaagcac cgagttacag ataacttttg atgagacaaa   4260 
               
               
                   
               
               
                 ccccattaca agactgtctg aaattgagaa gataagagac caagccctga acaattctag   4320 
               
               
                   
               
               
                 accacctgtt aggtatcaag ataacgcatg tgaaatggaa ctggtgaagg ttttgacacc   4380 
               
               
                   
               
               
                 cttagagata gctaagaaca agcagtatga tatgcataca gaagtcacaa cattaaaaca   4440 
               
               
                   
               
               
                 agaaaagaac ccagttccca gtgctgaaga atggatgctt gaagggtgca gagcatctgg   4500 
               
               
                   
               
               
                 tggactcaag aaaggggatt tccttaagaa gggcttagaa ccagagacct tccagaactt   4560 
               
               
                   
               
               
                 tgatggtgat catgcatgtt cagtcaggga tgatgaattt aaattccaag ggcttaggca   4620 
               
               
                   
               
               
                 cactgtgact gccaggcagt tggtggaagc taagcttctg gacatgagaa caattgagca   4680 
               
               
                   
               
               
                 gctgcgactc ggtcttaaga ctgttgaaga agttcagaaa actcttaaca agtttctgac   4740 
               
               
                   
               
               
                 gaaagccacc tcaattgcag ggctttacct agaatctaca aaagaaaaga tttcatttgc   4800 
               
               
                   
               
               
                 ctcagcggcc gagagaatca taatagacaa aatggtggct ttggcatttt tagaagctca   4860 
               
               
                   
               
               
                 ggctgcaaca ggttttataa ttgatcccat ttcaggtcag acatattctg ttgaagatgc   4920 
               
               
                   
               
               
                 agttcttaaa ggagttgttg accccgaatt cagaattagg cttcttgagg cagagaaggc   4980 
               
               
                   
               
               
                 agctgtggga tattcttatt cttctaagac attgtcagtg tttcaagcta tggaaaatag   5040 
               
               
                   
               
               
                 aatgcttgac agacaaaaag gtaaacatat cttggaagcc cagattgcca gtgggggtgt   5100 
               
               
                   
               
               
                 cattgaccct gtgagaggca ttcgtgttcc tccagaaatt gctctgcagc aggggttgtt   5160 
               
               
                   
               
               
                 gaataatgcc atcttacagt ttttacatga gccatccagc aacacaagag ttttccctaa   5220 
               
               
                   
               
               
                 tcccaataac aagcaagctc tgtattactc agaattactg cgaatgtgtg tatttgatgt   5280 
               
               
                   
               
               
                 agagtcccaa tgctttctgt ttccatttgg ggagaggaac atttccaatc tcaatgtcaa   5340 
               
               
                   
               
               
                 gaaaacacat agaatttctg tagtagatac taaaacagga tcagaattga ccgtgtatga   5400 
               
               
                   
               
               
                 ggctttccag agaaacctga ttgagaaaag tatatatctt gaactttcag ggcagcaata   5460 
               
               
                   
               
               
                 tcagtggaag gaagctatgt tttttgaatc ctatgggcat tcttctcata tgctgactga   5520 
               
               
                   
               
               
                 tactaaaaca ggattacact tcaatattaa tgaggctata gagcagggaa caattgacaa   5580 
               
               
                   
               
               
                 agccttggtc aaaaagtatc aggaaggcct catcacactt acagaacttg ctgattcttt   5640 
               
               
                   
               
               
                 gctgagccgg ttagtcccca agaaagattt gcacagtcct gttgcagggt attggctgac   5700 
               
               
                   
               
               
                 tgctagtggg gaaaggatct ctgtactaaa agcctcccgt agaaatttgg ttgatcggat   5760 
               
               
                   
               
               
                 tactgccctc cgatgccttg aagcccaagt cagtacaggg ggcataattg atcctcttac   5820 
               
               
                   
               
               
                 tggcaaaaag taccgggtgg ccgaagcttt gcatagaggc ctggttgatg aggggtttgc   5880 
               
               
                   
               
               
                 ccagcagctg cgacagtgtg aattagtaat cacagggatt ggccatccca tcactaacaa   5940 
               
               
                   
               
               
                 aatgatgtca gtggtggaag ctgtgaatgc aaatattata aataaggaaa tgggaatccg   6000 
               
               
                   
               
               
                 atgtttggaa tttcagtact tgacaggagg gttgatagag ccacaggttc actctcggtt   6060 
               
               
                   
               
               
                 atcaatagaa gaggctctcc aagtaggtat tatagatgtc ctcattgcca caaaactcaa   6120 
               
               
                   
               
               
                 agatcaaaag tcatatgtca gaaatataat atgccctcag acaaaaagaa agttgacata   6180 
               
               
                   
               
               
                 taaagaagcc ttagaaaaag ctgattttga tttccacaca ggacttaaac tgttagaagt   6240 
               
               
                   
               
               
                 atctgagccc ctgatgacag gaatttctag cctctactat tcttcctaat gggacatgtt   6300 
               
               
                   
               
               
                 taaataactg tgcaaggggt gatgcaggct ggttcatgcc actttttcag agtatgatga   6360 
               
               
                   
               
               
                 tatcggctac atatgcagtc tgtgaattat gtaacatact ctatttcttg agggctgcaa   6420 
               
               
                   
               
               
                 attgctaagt gctcaaaata gagtaagttt taaattgaaa attacataag atttaatgcc   6480 
               
               
                   
               
               
                 cttcaaatgg tttcatttag ccttgagaat ggttttttga aacttggcca cactaaaatg   6540 
               
               
                   
               
               
                 tttttttttt tttacgtaga atgtgggata aacttgatga actccaagtt cacagtgtca   6600 
               
               
                   
               
               
                 tttcttcaga actccccttc attgaatagt gatcatttat taaatgataa attgcactcg   6660 
               
               
                   
               
               
                 ctgaaagagc acgtcatgaa gcaccatgga atcaaagaga aagatataaa ttcgttccca   6720 
               
               
                   
               
               
                 cagccttcaa gctgcagtgt tttagattgc ttcaaaaaat gaaaaagttt tgcctttttc   6780 
               
               
                   
               
               
                 gatatagtga ccttctttgc atattaaaat gtttaccaca atgtcccatt tctagttaag   6840 
               
               
                   
               
               
                 tcttcgcact tgaaagctaa cattatgaat attatgtgtt ggaggagggg aaggattttc   6900 
               
               
                   
               
               
                 ttcattctgt gtattttccg g                                             6921 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 118 
               
               
                 &lt;211&gt; LENGTH: 946 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 118 
               
               
                   
               
               
                 cttctgactg ggctcaggct gacaggtaga gctcaccatg gcttcttgtg tccttgtccc     60 
               
               
                   
               
               
                 ctccccatca cagctgtggt gcagtccacc gtctccagtg gctatggcgg tgccagtggt    120 
               
               
                   
               
               
                 gtcggcagtg gcttaggcct gggtggagga agcagctact cctatggcag tggtcttggc    180 
               
               
                   
               
               
                 gttggaggtg gcttcagttc cagcagtggc agagccattg ggggtggcct cagctctgtt    240 
               
               
                   
               
               
                 ggaggcggca gttccaccat caagtacacc accacctcct cctccagcag gaagagctat    300 
               
               
                   
               
               
                 aagcactaaa gtgcgtctgc tagctctcgg tcccacagtc ctcaggcccc tctctggctg    360 
               
               
                   
               
               
                 cagagccctc tcctcaggtt gcctgtcctc tcctggcctc cagtctcccc tgctgtccca    420 
               
               
                   
               
               
                 ggtagagctg gggatgaatg cttagtgccc tcacttcttc tctctctctc tataccatct    480 
               
               
                   
               
               
                 gagcacccat tgctcaccat cagatcaacc tctgatttta catcatgatg taatcaccac    540 
               
               
                   
               
               
                 tggagcttca ctgttactaa attattaatt tcttgcctcc agtgttctat ctctgaggct    600 
               
               
                   
               
               
                 gagcattata agaaaatgac ctctgctcct tttcattgca gaaaattgcc aggggcttat    660 
               
               
                   
               
               
                 ttcagaacaa cttccactta ctttccactg gctctcaaac tctctaactt ataagtgttg    720 
               
               
                   
               
               
                 tgaaccccca cccaggcagt atccatgaaa gcacaagtga ctagtcctat gatgtacaaa    780 
               
               
                   
               
               
                 gcctgtatct ctgtgatgat ttctgtgctc ttcactgttt gcaattgcta aataaagcag    840 
               
               
                   
               
               
                 atttataata catatattct tttactttgc cttgctttgg ggccaaagtt ttgggcttaa    900 
               
               
                   
               
               
                 acttttttat ctgataagtg aatagttgtt tttaaaagat aatcta                   946 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 119 
               
               
                 &lt;211&gt; LENGTH: 8948 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 119 
               
               
                   
               
               
                 tcaacagccc ctgctccttg ggcccctcca tgccatgccg taatctctcc cacccgacca     60 
               
               
                   
               
               
                 acaccaacac ccagctccga cgcagctcct ctgcgccctt gccgccctcc gagccacagc    120 
               
               
                   
               
               
                 tttcctcccg ctcctgcccc cggcccgtcg ccgtctccgc gctcgcagcg gcctcgggag    180 
               
               
                   
               
               
                 ggcccaggta gcgagcagcg acctcgcgag ccttccgcac tcccgcccgg ttccccggcc    240 
               
               
                   
               
               
                 gtccgcctat ccttggcccc ctccgctttc tccgcgccgg cccgcctcgc ttatgcctcg    300 
               
               
                   
               
               
                 gcgctgagcc gctctcccga ttgcccgccg acatgagctg caacggaggc tcccacccgc    360 
               
               
                   
               
               
                 ggatcaacac tctgggccgc atgatccgcg ccgagtctgg cccggacctg cgctacgagg    420 
               
               
                   
               
               
                 tgaccagcgg cggcgggggc accagcagga tgtactattc tcggcgcggc gtgatcaccg    480 
               
               
                   
               
               
                 accagaactc ggacggctac tgtcaaaccg gcacgatgtc caggcaccag aaccagaaca    540 
               
               
                   
               
               
                 ccatccagga gctgctgcag aactgctccg actgcttgat gcgagcagag ctcatcgtgc    600 
               
               
                   
               
               
                 agcctgaatt gaagtatgga gatggaatac aactgactcg gagtcgagaa ttggatgagt    660 
               
               
                   
               
               
                 gttttgccca ggccaatgac caaatggaaa tcctcgacag cttgatcaga gagatgcggc    720 
               
               
                   
               
               
                 agatgggcca gccctgtgat gcttaccaga aaaggcttct tcagctccaa gagcaaatgc    780 
               
               
                   
               
               
                 gagcccttta taaagccatc agtgtccctc gagtccgcag ggccagctcc aagggtggtg    840 
               
               
                   
               
               
                 gaggctacac ttgtcagagt ggctctggct gggatgagtt caccaaacat gtcaccagtg    900 
               
               
                   
               
               
                 aatgtttggg gtggatgagg cagcaaaggg cggagatgga catggtggcc tggggtgtgg    960 
               
               
                   
               
               
                 acctggcctc agtggagcag cacattaaca gccaccgggg catccacaac tccatcggcg   1020 
               
               
                   
               
               
                 actatcgctg gcagctggac aaaatcaaag ccgacctgcg cgagaaatct gcgatctacc   1080 
               
               
                   
               
               
                 agttggagga ggagtatgaa aacctgctga aagcgtcctt tgagaggatg gatcacctgc   1140 
               
               
                   
               
               
                 gacagctgca gaacatcatt caggccacgt ccagggagat catgtggatc aatgactgcg   1200 
               
               
                   
               
               
                 aggaggagga gctgctgtac gactggagcg acaagaacac caacatcgct cagaaacagg   1260 
               
               
                   
               
               
                 aggccttctc catacgcatg agtcaactgg aagttaaaga aaaagagctc aataagctga   1320 
               
               
                   
               
               
                 aacaagaaag tgaccaactt gtcctcaatc agcatccagc ttcagacaaa attgaggcct   1380 
               
               
                   
               
               
                 atatggacac tctgcagacg cagtggagtt ggattcttca gatcaccaag tgcattgatg   1440 
               
               
                   
               
               
                 ttcatctgaa agaaaatgct gcctactttc agttttttga agaggcgcag tctactgaag   1500 
               
               
                   
               
               
                 catacctgaa ggggctccag gactccatca ggaagaagta cccctgcgac aagaacatgc   1560 
               
               
                   
               
               
                 ccctgcagca cctgctggaa cagatcaagg agctggagaa agaacgagag aaaatccttg   1620 
               
               
                   
               
               
                 aatacaagcg tcaggtgcag aacttggtaa acaagtctaa gaagattgta cagctgaagc   1680 
               
               
                   
               
               
                 ctcgtaaccc agactacaga agcaataaac ccattattct cagagctctc tgtgactaca   1740 
               
               
                   
               
               
                 aacaagatca gaaaatcgtg cataaggggg atgagtgtat cctgaaggac aacaacgagc   1800 
               
               
                   
               
               
                 gcagcaagtg gtacgtgacg ggcccgggag gcgttgacat gcttgttccc tctgtggggc   1860 
               
               
                   
               
               
                 tgatcatccc tcctccgaac ccactggccg tggacctctc ttgcaagatt gagcagtact   1920 
               
               
                   
               
               
                 acgaagccat cttggctctg tggaaccagc tctacatcaa catgaagagc ctggtgtcct   1980 
               
               
                   
               
               
                 ggcactactg catgattgac atagagaaga tcagggccat gacaatcgcc aagctgaaaa   2040 
               
               
                   
               
               
                 caatgcggca ggaagattac atgaagacga tagccgacct tgagttacat taccaagagt   2100 
               
               
                   
               
               
                 tcatcagaaa tagccaaggc tcagagatgt ttggagatga tgacaagcgg aaaatacagt   2160 
               
               
                   
               
               
                 ctcagttcac cgatgcccag aagcattacc agaccctggt cattcagctc cctggctatc   2220 
               
               
                   
               
               
                 cccagcacca gacagtgacc acaactgaaa tcactcatca tggaacctgc caagatgtca   2280 
               
               
                   
               
               
                 accataataa agtaattgaa accaacagag aaaatgacaa gcaagaaaca tggatgctga   2340 
               
               
                   
               
               
                 tggagctgca gaagattcgc aggcagatag agcactgcga gggcaggatg actctcaaaa   2400 
               
               
                   
               
               
                 acctccctct agcagaccag gggtcttctc accacatcac agtgaaaatt aacgagctta   2460 
               
               
                   
               
               
                 agagtgtgca gaatgattca caagcaattg ctgaggttct caaccagctt aaagatatgc   2520 
               
               
                   
               
               
                 ttgccaactt cagaggttct gaaaagtact gctatttaca gaatgaagta tttggactat   2580 
               
               
                   
               
               
                 ttcagaaact ggaaaatatc aatggtgtta cagatggcta cttaaatagc ttatgcacag   2640 
               
               
                   
               
               
                 taagggcact gctccaggct attctccaaa cagaagacat gttaaaggtt tatgaagcca   2700 
               
               
                   
               
               
                 ggctcactga ggaggaaact gtctgcctgg acctggataa agtggaagct taccgctgtg   2760 
               
               
                   
               
               
                 gactgaagaa aataaaaaat gacttgaact tgaagaagtc gttgttggcc actatgaaga   2820 
               
               
                   
               
               
                 cagaactaca gaaagcccag cagatccact ctcagacttc acagcagtat ccactttatg   2880 
               
               
                   
               
               
                 atctggactt gggcaagttc ggtgaaaaag tcacacagct gacagaccgc tggcaaagga   2940 
               
               
                   
               
               
                 tagataaaca gatcgacttt agattatggg acctggagaa acaaatcaag caattgagga   3000 
               
               
                   
               
               
                 attatcgtga taactatcag gctttctgca agtggctcta tgatcgtaaa cgccgccagg   3060 
               
               
                   
               
               
                 attccttaga atccatgaaa tttggagatt ccaacacagt catgcggttt ttgaatgagc   3120 
               
               
                   
               
               
                 agaagaactt gcacagtgaa atatctggca aacgagacaa atcagaggaa gtacaaaaaa   3180 
               
               
                   
               
               
                 ttgctgaact ttgcgccaat tcaattaagg attatgagct ccagctggcc tcatacacct   3240 
               
               
                   
               
               
                 caggactgga aactctgctg aacataccta tcaagaggac catgattcag tccccttctg   3300 
               
               
                   
               
               
                 gggtgattct gcaagaggct gcagatgttc atgctcggta cattgaacta cttacaagat   3360 
               
               
                   
               
               
                 ctggagacta ttacaggttc ttaagtgaga tgctgaagag tttggaagat ctgaagctga   3420 
               
               
                   
               
               
                 aaaataccaa gatcgaagtt ttggaagagg agctcagact ggcccgagat gccaactcgg   3480 
               
               
                   
               
               
                 aaaactgtaa taagaacaaa ttcctggatc agaacctgca gaaataccag gcagagtgtt   3540 
               
               
                   
               
               
                 cccagttcaa agcgaagctt gcgagcctgg aggagctgaa gagacaggct gagctggatg   3600 
               
               
                   
               
               
                 ggaagtcggc taagcaaaat ctagacaagt gctacggcca aataaaagaa ctcaatgaga   3660 
               
               
                   
               
               
                 agatcacccg actgacttat gagattgaag atgaaaagag aagaagaaaa tctgtggaag   3720 
               
               
                   
               
               
                 acagatttga ccaacagaag aatgactatg accaactgca gaaagcaagg caatgtgaaa   3780 
               
               
                   
               
               
                 aggagaacct tggttggcag aaattagagt ctgagaaagc catcaaggag aaggagtacg   3840 
               
               
                   
               
               
                 agattgaaag gttgagggtt ctactgcagg aagaaggcac ccggaagaga gaatatgaaa   3900 
               
               
                   
               
               
                 atgagctggc aaaggtaaga aaccactata atgaggagat gagtaattta aggaacaagt   3960 
               
               
                   
               
               
                 atgaaacaga gattaacatt acgaagacca ccatcaagga gatatccatg caaaaagagg   4020 
               
               
                   
               
               
                 atgattccaa aaatcttaga aaccagcttg atagactttc aagggaaaat cgagatctga   4080 
               
               
                   
               
               
                 aggatgaaat tgtcaggctc aatgacagca tcttgcaggc cactgagcag cgaaggcgag   4140 
               
               
                   
               
               
                 ctgaagaaaa cgcccttcag caaaaggcct gtggctctga gataatgcag aagaagcagc   4200 
               
               
                   
               
               
                 atctggagat agaactgaag caggtcatgc agcagcgctc tgaggacaat gcccggcaca   4260 
               
               
                   
               
               
                 agcagtccct ggaggaggct gccaagacca ttcaggacaa aaataaggag atcgagagac   4320 
               
               
                   
               
               
                 tcaaagctga gtttcaggag gaggccaagc gccgctggga atatgaaaat gaactgagta   4380 
               
               
                   
               
               
                 aggtaagaaa caattatgat gaggagatca ttagcttaaa aaatcagttt gagaccgaga   4440 
               
               
                   
               
               
                 tcaacatcac caagaccacc atccaccagc tcaccatgca gaaggaagag gataccagtg   4500 
               
               
                   
               
               
                 gctaccgggc tcagatagac aatctcaccc gagaaaacag gagcttatct gaagaaataa   4560 
               
               
                   
               
               
                 agaggctgaa gaacactcta acccagacca cagagaatct caggagggtg gaagaagaca   4620 
               
               
                   
               
               
                 tccaacagca aaaggccact ggctctgagg tgtctcagag gaaacagcag ctggaggttg   4680 
               
               
                   
               
               
                 agctgagaca agtcactcag atgcgaacag aggagagcgt aagatataag caatctcttg   4740 
               
               
                   
               
               
                 atgatgctgc caaaaccatc caggataaaa acaaggagat agaaaggtta aaacaactga   4800 
               
               
                   
               
               
                 tcgacaaaga aacaaatgac cggaaatgcc tggaagatga aaacgcgaga ttacaaaggg   4860 
               
               
                   
               
               
                 tccagtatga cctgcagaaa gcaaacagta gtgcgacgga gacaataaac aaactgaagg   4920 
               
               
                   
               
               
                 ttcaggagca agaactgaca cgcctgagga tcgactatga aagggtttcc caggagagga   4980 
               
               
                   
               
               
                 ctgtgaagga ccaggatatc acgcggttcc agaactctct gaaagagctg cagctgcaga   5040 
               
               
                   
               
               
                 agcagaaggt ggaagaggag ctgaatcggc tgaagaggac cgcgtcagaa gactcctgca   5100 
               
               
                   
               
               
                 agaggaagaa gctggaggaa gagctggaag gcatgaggag gtcgctgaag gagcaagcca   5160 
               
               
                   
               
               
                 tcaaaatcac caacctgacc cagcagctgg agcaggcatc cattgttaag aagaggagtg   5220 
               
               
                   
               
               
                 aggatgacct ccggcagcag agggacgtgc tggatggcca cctgagggaa aagcagagga   5280 
               
               
                   
               
               
                 cccaggaaga gctgaggagg ctctcttctg aggtcgaggc cctgaggcgg cagttactcc   5340 
               
               
                   
               
               
                 aggaacagga aagtgtcaaa caagctcact tgaggaatga gcatttccag aaggcgatag   5400 
               
               
                   
               
               
                 aagataaaag cagaagctta aatgaaagca aaatagaaat tgagaggctg cagtctctca   5460 
               
               
                   
               
               
                 cagagaacct gaccaaggag cacttgatgt tagaagaaga actgcggaac ctgaggctgg   5520 
               
               
                   
               
               
                 agtacgatga cctgaggaga ggacgaagcg aagcggacag tgataaaaat gcaaccatct   5580 
               
               
                   
               
               
                 tggaactaag gagccagctg cagatcagca acaaccggac cctggaactg caggggctga   5640 
               
               
                   
               
               
                 ttaatgattt acagagagag agggaaaatt tgagacagga aattgagaaa ttccaaaagc   5700 
               
               
                   
               
               
                 aggctttaga ggcatctaat aggattcagg aatcaaagaa tcagtgtact caggtggtac   5760 
               
               
                   
               
               
                 aggaaagaga gagccttctg gtgaaaatca aagtcctgga gcaagacaag gcaaggctgc   5820 
               
               
                   
               
               
                 agaggctgga ggatgagctg aatcgtgcaa aatcaactct agaggcagaa accagggtga   5880 
               
               
                   
               
               
                 aacagcgcct ggagtgtgag aaacagcaaa ttcagaatga cctgaatcag tggaagactc   5940 
               
               
                   
               
               
                 aatattcccg caaggaggag gctattagga agatagaatc ggaaagagaa aagagtgaga   6000 
               
               
                   
               
               
                 gagagaagaa cagtcttagg agtgagatcg aaagactcca agcagagatc aagagaattg   6060 
               
               
                   
               
               
                 aagagaggtg caggcgtaag ctggaggatt ctaccaggga gacacagtca cagttagaaa   6120 
               
               
                   
               
               
                 cagaacgctc ccgatatcag agggagattg ataaactcag acagcgccca tatgggtccc   6180 
               
               
                   
               
               
                 atcgagagac ccagactgag tgtgagtgga ccgttgacac ctccaagctg gtgtttgatg   6240 
               
               
                   
               
               
                 ggctgaggaa gaaggtgaca gcaatgcagc tctatgagtg tcagctgatc gacaaaacaa   6300 
               
               
                   
               
               
                 ccttggacaa actattgaag gggaagaagt cagtggaaga agttgcttct gaaatccagc   6360 
               
               
                   
               
               
                 cattccttcg gggtgcagga tctatcgctg gagcatctgc ttctcctaag gaaaaatact   6420 
               
               
                   
               
               
                 ctttggtaga ggccaagaga aagaaattaa tcagcccaga atccacagtc atgcttctgg   6480 
               
               
                   
               
               
                 aggcccaggc agctacaggt ggtataattg atccccatcg gaatgagaag ctgactgtcg   6540 
               
               
                   
               
               
                 acagtgccat agctcgggac ctcattgact tcgatgaccg tcagcagata tatgcagcag   6600 
               
               
                   
               
               
                 aaaaagctat cactggtttt gatgatccat tttcaggcaa gacagtatct gtttcagaag   6660 
               
               
                   
               
               
                 ccatcaagaa aaatttgatt gatagagaaa ccggaatgcg cctgctggaa gcccagattg   6720 
               
               
                   
               
               
                 cttcaggggg tgtagtagac cctgtgaaca gtgtcttttt gccaaaagat gtcgccttgg   6780 
               
               
                   
               
               
                 cccgggggct gattgataga gatttgtatc gatccctgaa tgatccccga gatagtcaga   6840 
               
               
                   
               
               
                 aaaactttgt ggatccagtc accaaaaaga aggtcagtta cgtgcagctg aaggaacggt   6900 
               
               
                   
               
               
                 gcagaatcga accacatact ggtctgctct tgctttcagt acagaagaga agcatgtcct   6960 
               
               
                   
               
               
                 tccaaggaat cagacaacct gtgaccgtca ctgagctagt agattctggt atattgagac   7020 
               
               
                   
               
               
                 cgtccactgt caatgaactg gaatctggtc agatttctta tgacgaggtt ggtgagagaa   7080 
               
               
                   
               
               
                 ttaaggactt cctccagggt tcaagctgca tagcaggcat atacaatgag accacaaaac   7140 
               
               
                   
               
               
                 agaagcttgg catttatgag gccatgaaaa ttggcttagt ccgacctggt actgctctgg   7200 
               
               
                   
               
               
                 agttgctgga agcccaagca gctactggct ttatagtgga tcctgttagc aacttgaggt   7260 
               
               
                   
               
               
                 taccagtgga ggaagcctac aagagaggtc tggtgggcat tgagttcaaa gagaagctcc   7320 
               
               
                   
               
               
                 tgtctgcaga acgagctgtc actgggtata atgatcctga aacaggaaac atcatctctt   7380 
               
               
                   
               
               
                 tgttccaagc catgaataag gaactcatcg aaaagggcca cggtattcgc ttattagaag   7440 
               
               
                   
               
               
                 cacagatcgc aaccgggggg atcattgacc caaaggagag ccatcgttta ccagttgaca   7500 
               
               
                   
               
               
                 tagcatataa gaggggctat ttcaatgagg aactcagtga gattctctca gatccaagtg   7560 
               
               
                   
               
               
                 atgataccaa aggatttttt gaccccaaca ctgaagaaaa tcttacctat ctgcaactaa   7620 
               
               
                   
               
               
                 aagaaagatg cattaaggat gaggaaacag ggctctgtct tctgcctctg aaagaaaaga   7680 
               
               
                   
               
               
                 agaaacaggt gcagacatca caaaagaata ccctcaggaa gcgtagagtg gtcatagttg   7740 
               
               
                   
               
               
                 acccagaaac caataaagaa atgtctgttc aggaggccta caagaagggc ctaattgatt   7800 
               
               
                   
               
               
                 atgaaacctt caaagaactg tgtgagcagg aatgtgaatg ggaagaaata accatcacgg   7860 
               
               
                   
               
               
                 gatcagatgg ctccaccagg gtggtcctgg tagatagaaa gacaggcagt cagtatgata   7920 
               
               
                   
               
               
                 ttcaagatgc tattgacaag ggccttgttg acaggaagtt ctttgatcag taccgatccg   7980 
               
               
                   
               
               
                 gcagcctcag cctcactcaa tttgctgaca tgatctcctt gaaaaatggt gtcggcacca   8040 
               
               
                   
               
               
                 gcagcagcat gggcagtggt gtcagcgatg atgtttttag cagctcccga catgaatcag   8100 
               
               
                   
               
               
                 taagtaagat ttccaccata tccagcgtca ggaatttaac cataaggagc agctcttttt   8160 
               
               
                   
               
               
                 cagacaccct ggaagaatcg agccccattg cagccatctt tgacacagaa aacctggaga   8220 
               
               
                   
               
               
                 aaatctccat tacagaaggt atagagcggg gcatcgttga cagcatcacg ggtcagaggc   8280 
               
               
                   
               
               
                 ttctggaggc tcaggcctgc acaggtggca tcatccaccc aaccacgggc cagaagctgt   8340 
               
               
                   
               
               
                 cacttcagga cgcagtctcc cagggtgtga ttgaccaaga catggccacc agcgtgaagc   8400 
               
               
                   
               
               
                 ctgctcagaa agccttcata ggcttcgagg gtgtgaaggg aaagaagaag atgtcagcag   8460 
               
               
                   
               
               
                 cagaggcagt gaaagaaaaa tggctcccgt atgaggctgg ccagcgcttc ctggagttcc   8520 
               
               
                   
               
               
                 agtacctcac gggaggtctt gttgacccgg aagtgcatgg gaggataagc accgaagaag   8580 
               
               
                   
               
               
                 ccatccggaa ggggttcata gatggccgcg ccgcacagag gctgcaagac accagcagct   8640 
               
               
                   
               
               
                 atgccaaaat cctgacctgc cccaaaacca aattaaaaat atcctataag gatgccataa   8700 
               
               
                   
               
               
                 atcgctccat ggtagaagat atcactgggc tgcgccttct ggaagccgcc tccgtgtcgt   8760 
               
               
                   
               
               
                 ccaagggctt acccagccct tacaacatgt cttcggctcc ggggtcccgc tccggctccc   8820 
               
               
                   
               
               
                 gctcgggatc tcgctccgga tctcgctccg ggtcccgcag tgggtcccgg agaggaagct   8880 
               
               
                   
               
               
                 ttgacgccac agggaattct tcctactctt attcctactc atttagcagt agttctattg   8940 
               
               
                   
               
               
                 ggcactag                                                            8948 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 120 
               
               
                 &lt;211&gt; LENGTH: 587 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (91) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (131) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (256) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (263) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (332) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (392) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (400) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (403) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (461) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (496) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (497) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (499) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (510) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (511) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (518) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (539) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (554) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (560) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (576) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 120 
               
               
                   
               
               
                 cgtcctaagc acttagacta catcagggaa gaacacagac cacatccctg tcctcatgcg     60 
               
               
                   
               
               
                 gcttatgttt tctggaagaa agtggagacc nagtccttgg ctttagggct ccccggctgg    120 
               
               
                   
               
               
                 gggctgtgca ntccggtcag ggcgggaagg gaaatgcacc gctgcatgtg aacttacagc    180 
               
               
                   
               
               
                 ccaggcggat gccccttccc ttagcactac ctggcctcct gcatcccctc gcctcatgtt    240 
               
               
                   
               
               
                 cctcccacct tcaaanaatg aanaacccca tgggcccagc cccttgccct ggggaaccaa    300 
               
               
                   
               
               
                 ggcagccttc caaaactcag gggctgaagc anactattag ggcaggggct gactttgggt    360 
               
               
                   
               
               
                 gacactgccc attccctctc agggcagctc angtcacccn ggnctcttga acccagcctg    420 
               
               
                   
               
               
                 ttcctttgaa aaagggcaaa actgaaaagg gcttttccta naaaaagaaa aaccagggaa    480 
               
               
                   
               
               
                 ctttgccagg gcttcnntnt taccaaaacn ncttctcnng gatttttaat tccccattng    540 
               
               
                   
               
               
                 gcctccactt accnggggcn atgccccaaa attaanaatt tcccatc                  587 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 121 
               
               
                 &lt;211&gt; LENGTH: 619 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (260) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (527) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (560) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (564) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (566) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (585) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (599) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 121 
               
               
                   
               
               
                 cactagtagg atagaaacac tgtgtcccga gagtaaggag agaagctact attgattaga     60 
               
               
                   
               
               
                 gcctaaccca ggttaactgc aagaagaggc gggatacttt cagctttcca tgtaactgta    120 
               
               
                   
               
               
                 tgcataaagc caatgtagtc cagtttctaa gatcatgttc caagctaact gaatcccact    180 
               
               
                   
               
               
                 tcaatacaca ctcatgaact cctgatggaa caataacagg cccaagcctg tggtatgatg    240 
               
               
                   
               
               
                 tgcacacttg ctagactcan aaaaaatact actctcataa atgggtggga gtattttggt    300 
               
               
                   
               
               
                 gacaacctac tttgcttggc tgagtgaagg aatgatattc atatattcat ttattccatg    360 
               
               
                   
               
               
                 gacatttagt tagtgctttt tatataccag gcatgatgct gagtgacact cttgtgtata    420 
               
               
                   
               
               
                 tttccaaatt tttgtacagt cgctgcacat atttgaaatc atatattaag acttccaaaa    480 
               
               
                   
               
               
                 aatgaagtcc ctggtttttc atggcaactt gatcagtaaa ggattcncct ctgtttggta    540 
               
               
                   
               
               
                 cttaaaacat ctactatatn gttnanatga aattcctttt ccccncctcc cgaaaaaana    600 
               
               
                   
               
               
                 aagtggtggg gaaaaaaaa                                                 619 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 122 
               
               
                 &lt;211&gt; LENGTH: 1475 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 122 
               
               
                   
               
               
                 tccacctgtc cccgcagcgc cggctcgcgc cctcctgccg cagccaccga gccgccgtct     60 
               
               
                   
               
               
                 agcgccccga cctcgccacc atgagagccc tgctggcgcg cctgcttctc tgcgtcctgg    120 
               
               
                   
               
               
                 tcgtgagcga ctccaaaggc agcaatgaac ttcatcaagt tccatcgaac tgtgactgtc    180 
               
               
                   
               
               
                 taaatggagg aacatgtgtg tccaacaagt acttctccaa cattcactgg tgcaactgcc    240 
               
               
                   
               
               
                 caaagaaatt cggagggcag cactgtgaaa tagataagtc aaaaacctgc tatgagggga    300 
               
               
                   
               
               
                 atggtcactt ttaccgagga aaggccagca ctgacaccat gggccggccc tgcctgccct    360 
               
               
                   
               
               
                 ggaactctgc cactgtcctt cagcaaacgt accatgccca cagatctgat gctcttcagc    420 
               
               
                   
               
               
                 tgggcctggg gaaacataat tactgcagga acccagacaa ccggaggcga ccctggtgct    480 
               
               
                   
               
               
                 atgtgcaggt gggcctaaag ccgcttgtcc aagagtgcat ggtgcatgac tgcgcagatg    540 
               
               
                   
               
               
                 gaaaaaagcc ctcctctcct ccagaagaat taaaatttca gtgtggccaa aagactctga    600 
               
               
                   
               
               
                 ggccccgctt taagattatt gggggagaat tcaccaccat cgagaaccag ccctggtttg    660 
               
               
                   
               
               
                 cggccatcta caggaggcac cgggggggct ctgtcaccta cgtgtgtgga ggcagcctca    720 
               
               
                   
               
               
                 tcagcccttg ctgggtgatc agcgccacac actgcttcat tgattaccca aagaaggagg    780 
               
               
                   
               
               
                 actacatcgt ctacctgggt cgctcaaggc ttaactccaa cacgcaaggg gagatgaagt    840 
               
               
                   
               
               
                 ttgaggtgga aaacctcatc ctacacaagg actacagcgc tgacacgctt gctcaccaca    900 
               
               
                   
               
               
                 acgacattgc cttgctgaag atccgttcca aggagggcag gtgtgcgcag ccatcccgga    960 
               
               
                   
               
               
                 ctatacagac catctgcctg ccctcgatgt ataacgatcc ccagtttggc acaagctgtg   1020 
               
               
                   
               
               
                 agatcactgg ctttggaaaa gagaattcta ccgactatct ctatccggag cagctgaaga   1080 
               
               
                   
               
               
                 tgactgttgt gaagctgatt tcccaccggg agtgtcagca gccccactac tacggctctg   1140 
               
               
                   
               
               
                 aagtcaccac caaaatgctg tgtgctgctg acccacagtg gaaaacagat tcctgccagg   1200 
               
               
                   
               
               
                 gagactcagg gggacccctc gtctgttccc tccaaggccg catgactttg actggaattg   1260 
               
               
                   
               
               
                 tgagctgggg ccgtggatgt gccctgaagg acaagccagg cgtctacacg agagtctcac   1320 
               
               
                   
               
               
                 acttcttacc ctggatccgc agtcacacca aggaagagaa tggcctggcc ctctgagggt   1380 
               
               
                   
               
               
                 ccccagggag gaaacgggca ccacccgctt tcttgctggt tgtcattttt gcagtagagt   1440 
               
               
                   
               
               
                 catctccatc agctgtaaga agagactggg aagat                              1475 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 123 
               
               
                 &lt;211&gt; LENGTH: 2294 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 123 
               
               
                   
               
               
                 cagcgccggc tcgcgccctc ctgccgcagc caccgagccg ccgtctagcg ccccgacctc     60 
               
               
                   
               
               
                 gccaccatga gagccctgct ggcgcgcctg cttctctgcg tcctggtcgt gagcgactcc    120 
               
               
                   
               
               
                 aaaggcagca atgaacttca tcaagttcca tcgaactgtg actgtctaaa tggaggaaca    180 
               
               
                   
               
               
                 tgtgtgtcca acaagtactt ctccaacatt cactggtgca actgcccaaa gaaattcgga    240 
               
               
                   
               
               
                 gggcagcact gtgaaataga taagtcaaaa acctgctatg aggggaatgg tcacttttac    300 
               
               
                   
               
               
                 cgaggaaagg ccagcactga caccatgggc cggccctgcc tgccctggaa ctctgccact    360 
               
               
                   
               
               
                 gtccttcagc aaacgtacca tgcccacaga tctgatgctc ttcagctggg cctggggaaa    420 
               
               
                   
               
               
                 cataattact gcaggaaccc agacaaccgg aggcgaccct ggtgctatgt gcaggtgggc    480 
               
               
                   
               
               
                 ctaaagccgc ttgtccaaga gtgcatggtg catgactgcg cagatggaaa aaagccctcc    540 
               
               
                   
               
               
                 tctcctccag aagaattaaa atttcagtgt ggccaaaaga ctctgaggcc ccgctttaag    600 
               
               
                   
               
               
                 attattgggg gagaattcac caccatcgag aaccagccct ggtttgcggc catctacagg    660 
               
               
                   
               
               
                 aggcaccggg ggggctctgt cacctacgtg tgtggaggca gcctcatcag cccttgctgg    720 
               
               
                   
               
               
                 gtgatcagcg ccacacactg cttcattgat tacccaaaga aggaggacta catcgtctac    780 
               
               
                   
               
               
                 ctgggtcgct caaggcttaa ctccaacacg caaggggaga tgaagtttga ggtggaaaac    840 
               
               
                   
               
               
                 ctaatcctac acaaggacta cagcgctgac acgcttgctc accacaacga cattgccttg    900 
               
               
                   
               
               
                 ctgaagatcc gttccaagga gggcaggtgt gcgcagccat cccggactat acagaccatc    960 
               
               
                   
               
               
                 tgcctgccct cgatgtataa cgatccccag tttggcacaa gctgtgagat cactggcttt   1020 
               
               
                   
               
               
                 ggaaaagaga attctaccga ctatctctat ccggagcagc tgaaaatgac tgttgtgaag   1080 
               
               
                   
               
               
                 ctgatttccc accgggagtg tcagcagccc cactactacg gctctgaagt caccaccaaa   1140 
               
               
                   
               
               
                 atgctgtgtg ctgctgaccc acagtggaaa acagattcct gccagggaga ctcaggggga   1200 
               
               
                   
               
               
                 cccctcgtct gttccctcca aggccgcatg actttgactg gaattgtgag ctggggccgt   1260 
               
               
                   
               
               
                 ggatgtgccc tgaaggacaa gccaggcgtc tacacgagag tctcacactt cttaccctgg   1320 
               
               
                   
               
               
                 atccgcagtc acaccaagga agagaatggc ctggccctct gagggtcccc agggaggaaa   1380 
               
               
                   
               
               
                 cgggcaccac ccgctttctt gctggttgct attttgcagt agagtcatct ccatcagctg   1440 
               
               
                   
               
               
                 taagaagagc tgggaatata ggctctgcac agatggattt gcctgtgcca ccaccagggc   1500 
               
               
                   
               
               
                 gaacgacaat agctttaccc tcaggcatag gcctgggtgc tggctgccca gacccctctg   1560 
               
               
                   
               
               
                 gccaggatgg aggggtggtc ctgactcaac atgttactga ccagcaactt gtctttttct   1620 
               
               
                   
               
               
                 ggactgaagc ctgcaggagt taaaaagggc agggcatctc ctgtgcatgg gctcgaaggg   1680 
               
               
                   
               
               
                 agagccagct cccccgaccg gtgggcattt gtgaggccca tggttgagaa atgaataatt   1740 
               
               
                   
               
               
                 tcccaattag gaagtgtaag cagctgaggt ctcttgaggg agcttagcca atgtgggagc   1800 
               
               
                   
               
               
                 agcggtttgg ggagcagaga cactaacgac ttcagggcag ggctctgata ttccatgaat   1860 
               
               
                   
               
               
                 gtatcaggaa atatatatgt gtgtgtatgt ttgcacactt gtgtgtgggc tgtgagtgta   1920 
               
               
                   
               
               
                 agtgtgagta agagctggtg tctgattgtt aagtctaaat atttccttaa actgtgtgga   1980 
               
               
                   
               
               
                 ctgtgatgcc acacagagtg gtctttctgg agaggttata ggtcactcct ggggcctctt   2040 
               
               
                   
               
               
                 gggtccccca cgtgacagtg cctgggaatg tattattctg cagcatgacc tgtgaccagc   2100 
               
               
                   
               
               
                 actgtctcag tttcactttc acatagatgt ccctttcttg gccagttatc ccttcctttt   2160 
               
               
                   
               
               
                 agcctagttc atccaatcct cactgggtgg ggtgaggacc actcctgtac actgaatatt   2220 
               
               
                   
               
               
                 tatatttcac tatttttatt tatatttttg taattttaaa taaaagtgat caataaaatg   2280 
               
               
                   
               
               
                 tgatttttct gatg                                                     2294 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 124 
               
               
                 &lt;211&gt; LENGTH: 956 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 124 
               
               
                   
               
               
                 gatgagttcc gcaccaagtt tgagacagac caggccctgc gcctgagtgt ggaggccgac     60 
               
               
                   
               
               
                 atcaatggcc tgcgcagggt gctggatgag ctgaccctgg ccagagccga cctggagatg    120 
               
               
                   
               
               
                 cagattgaga acctcaagga ggagctggcc tacctgaaga agaaccacga ggaggagatg    180 
               
               
                   
               
               
                 aacgccctgc gaggccaggt gggtggtgag atcaatgtgg agatggacgc tgccccaggc    240 
               
               
                   
               
               
                 gtggacctga gccgcatcct caacgagatg cgtgaccagt atgagaagat ggcagagaag    300 
               
               
                   
               
               
                 aaccgcaagg atgccgagga ttggttcttc agcaagacag aggaactgaa ccgcgaggtg    360 
               
               
                   
               
               
                 gccaccaaca gtgagctggt gcagagtggc aagagtgaga tctcggagct ccggcgcacc    420 
               
               
                   
               
               
                 atgcaggcct tggagataga gctgcagtcc cagctcagca tgaaagcatc cctggagggc    480 
               
               
                   
               
               
                 aacctggcgg agacagagaa ccgctactgc gtgcagctgt cccagatcca ggggctgatt    540 
               
               
                   
               
               
                 ggcagcgtgg aggagcagct ggcccagctt cgctgcgaga tggagcagca gaaccaggaa    600 
               
               
                   
               
               
                 tacaaaatcc tgctggatgt gaagacgcgg ctggagcagg agattgccac ctaccgccgc    660 
               
               
                   
               
               
                 ctgctggagg gagaggatgc ccacctgact cagtacaaga aagaaccggt gaccacccgt    720 
               
               
                   
               
               
                 caggtgcgta ccattgtgga agaggtccag gatggcaagg tcatctcctc ccgcgagcag    780 
               
               
                   
               
               
                 gtccaccaga ccacccgctg aggactcagc taccccggcc ggccacccag gaggcaggga    840 
               
               
                   
               
               
                 cgcagccgcc ccatctgccc cacagtctcc ggcctctcca gcctcagccc cctgcttcag    900 
               
               
                   
               
               
                 tcccttcccc atgcttcctt gcctgatgac aataaaagct tgttgactca gctatg        956 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 125 
               
               
                 &lt;211&gt; LENGTH: 486 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (16)...(16) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 125 
               
               
                   
               
               
                 aaattatata tagtgnttca gctcccattg tggtgttcat agtcttctag gaacagataa     60 
               
               
                   
               
               
                 acttaagtat tcaattcact cttggcattt tttctttaat ataggctttt tagcctattt    120 
               
               
                   
               
               
                 ttggaaaact gcttttcttc tgagaacctt attctgaatg tcatcaactt taccaaacct    180 
               
               
                   
               
               
                 tctaagtcca gagctaactt agtactgttt aagttactat tgactgaatt ttcttcattt    240 
               
               
                   
               
               
                 tctgtttagc cagtgttacc aaggtaagct ggggaatgaa gtataccaac ttctttcaga    300 
               
               
                   
               
               
                 gcattttagg acattatggc agctttagaa ggctgtcttg tttctagcca agggagagcc    360 
               
               
                   
               
               
                 agcgcaggtt ttggatacta gagaaagtca tttgcttgta ctattgccat tttagaaagc    420 
               
               
                   
               
               
                 tctgatgtga attcaaattt tacctctgtt acttaaagcc aacaatttta aggcagtagt    480 
               
               
                   
               
               
                 tttact                                                               486 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 126 
               
               
                 &lt;211&gt; LENGTH: 3552 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 126 
               
               
                   
               
               
                 cggcaggcag gtctcgtctc ggcaccctcc cggcgcccgc gttctcctgg ccctgcccgg     60 
               
               
                   
               
               
                 catcccgatg gccgccgctg ggccccggcg ctccgtgcgc ggagccgtct gcctgcatct    120 
               
               
                   
               
               
                 gctgctgacc ctcgtgatct tcagtcgtgc tggtgaagcc tgcaaaaagg tgatacttaa    180 
               
               
                   
               
               
                 tgtaccttct aaactagagg cagacaaaat aattggcaga gttaatttgg aagagtgctt    240 
               
               
                   
               
               
                 caggtctgca gacctcatcc ggtcaagtga tcctgatttc agagttctaa atgatgggtc    300 
               
               
                   
               
               
                 agtgtacaca gccagggctg ttgcgctgtc tgataagaaa agatcattta ccatatggct    360 
               
               
                   
               
               
                 ttctgacaaa aggaaacaga cacagaaaga ggttactgtg ctgctagaac atcagaagaa    420 
               
               
                   
               
               
                 ggtatcgaag acaagacaca ctagagaaac tgttctcagg cgtgccaaga ggagatgggc    480 
               
               
                   
               
               
                 acctattcct tgctctatgc aagagaattc cttgggccct ttcccattgt ttcttcaaca    540 
               
               
                   
               
               
                 agttgaatct gatgcagcac agaactatac tgtcttctac tcaataagtg gacgtggagt    600 
               
               
                   
               
               
                 tgataaagaa cctttaaatt tgttttatat agaaagagac actggaaatc tattttgcac    660 
               
               
                   
               
               
                 tcggcctgtg gatcgtgaag aatatgatgt ttttgatttg attgcttatg cgtcaactgc    720 
               
               
                   
               
               
                 agatggatat tcagcagatc tgcccctccc actacccatc agggtagagg atgaaaatga    780 
               
               
                   
               
               
                 caaccaccct gttttcacag aagcaattta taattttgaa gttttggaaa gtagtagacc    840 
               
               
                   
               
               
                 tggtactaca gtgggggtgg tttgtgccac agacagagat gaaccggaca caatgcatac    900 
               
               
                   
               
               
                 gcgcctgaaa tacagcattt tgcagcagac accaaggtca cctgggctct tttctgtgca    960 
               
               
                   
               
               
                 tcccagcaca ggcgtaatca ccacagtctc tcattatttg gacagagagg ttgtagacaa   1020 
               
               
                   
               
               
                 gtactcattg ataatgaaag tacaagacat ggatggccag ttttttggat tgataggcac   1080 
               
               
                   
               
               
                 atcaacttgt atcataacag taacagattc aaatgataat gcacccactt tcagacaaaa   1140 
               
               
                   
               
               
                 tgcttatgaa gcatttgtag aggaaaatgc attcaatgtg gaaatcttac gaatacctat   1200 
               
               
                   
               
               
                 agaagataag gatttaatta acactgccaa ttggagagtc aattttacca ttttaaaggg   1260 
               
               
                   
               
               
                 aaatgaaaat ggacatttca aaatcagcac agacaaagaa actaatgaag gtgttctttc   1320 
               
               
                   
               
               
                 tgttgtaaag ccactgaatt atgaagaaaa ccgtcaagtg aacctggaaa ttggagtaaa   1380 
               
               
                   
               
               
                 caatgaagcg ccatttgcta gagatattcc cagagtgaca gccttgaaca gagccttggt   1440 
               
               
                   
               
               
                 tacagttcat gtgagggatc tggatgaggg gcctgaatgc actcctgcag cccaatatgt   1500 
               
               
                   
               
               
                 gcggattaaa gaaaacttag cagtggggtc aaagatcaac ggctataagg catatgaccc   1560 
               
               
                   
               
               
                 cgaaaataga aatggcaatg gtttaaggta caaaaaattg catgatccta aaggttggat   1620 
               
               
                   
               
               
                 caccattgat gaaatttcag ggtcaatcat aacttccaaa atcctggata gggaggttga   1680 
               
               
                   
               
               
                 aactcccaaa aatgagttgt ataatattac agtcctggca atagacaaag atgatagatc   1740 
               
               
                   
               
               
                 atgtactgga acacttgctg tgaacattga agatgtaaat gataatccac cagaaatact   1800 
               
               
                   
               
               
                 tcaagaatat gtagtcattt gcaaaccaaa aatggggtat accgacattt tagctgttga   1860 
               
               
                   
               
               
                 tcctgatgaa cctgtccatg gagctccatt ttatttcagt ttgcccaata cttctccaga   1920 
               
               
                   
               
               
                 aatcagtaga ctgtggagcc tcaccaaagt taatgataca gctgcccgtc tttcatatca   1980 
               
               
                   
               
               
                 gaaaaatgct ggatttcaag aatataccat tcctattact gtaaaagaca gggccggcca   2040 
               
               
                   
               
               
                 agctgcaaca aaattattga gagttaatct gtgtgaatgt actcatccaa ctcagtgtcg   2100 
               
               
                   
               
               
                 tgcgacttca aggagtacag gagtaatact tggaaaatgg gcaatccttg caatattact   2160 
               
               
                   
               
               
                 gggtatagca ctgctctttt ctgtattgct aactttagta tgtggagttt ttggtgcaac   2220 
               
               
                   
               
               
                 taaagggaaa cgttttcctg aagatttagc acagcaaaac ttaattatat caaacacaga   2280 
               
               
                   
               
               
                 agcacctgga gacgatagag tgtgctctgc caatggattt atgacccaaa ctaccaacaa   2340 
               
               
                   
               
               
                 ctctagccaa ggtttttgtg gtactatggg atcaggaatg aaaaatggag ggcaggaaac   2400 
               
               
                   
               
               
                 cattgaaatg atgaaaggag gaaaccagac cttggaatcc tgccgggggg ctgggcatca   2460 
               
               
                   
               
               
                 tcataccctg gactcctgca ggggaggaca cacggaggtg gacaactgca gatacactta   2520 
               
               
                   
               
               
                 ctcggagtgg cacagtttta ctcaaccccg tctcggtgaa aaattgcatc gatgtaatca   2580 
               
               
                   
               
               
                 gaatgaagac cgcatgccat cccaagatta tgtcctcact tataactatg agggaagagg   2640 
               
               
                   
               
               
                 atctccagct ggttctgtgg gctgctgcag tgaaaagcag gaagaagatg gccttgactt   2700 
               
               
                   
               
               
                 tttaaataat ttggaaccca aatttattac attagcagaa gcatgcacaa agagataatg   2760 
               
               
                   
               
               
                 tcacagtgct acaattaggt ctttgtcaga cattctggag gtttccaaaa ataatattgt   2820 
               
               
                   
               
               
                 aaagttcaat ttcaacatgt atgtatatga tgattttttt ctcaattttg aattatgcta   2880 
               
               
                   
               
               
                 ctcaccaatt tatattttta aagcaagttg ttgcttatct tttccaaaaa gtgaaaaatg   2940 
               
               
                   
               
               
                 ttaaaacaga caactggtaa atctcaaact ccagcactgg aattaaggtc tctaaagcat   3000 
               
               
                   
               
               
                 ctgctctttt ttttttttac agatatttta gtaataaata tgctggataa atattagtcc   3060 
               
               
                   
               
               
                 aacaatagct aagttatgct aatatcacat tattatgtat tcactttaag tgatagttta   3120 
               
               
                   
               
               
                 aaaaataaac aagaaatatt gagtatcact atgtgaagaa agttttggaa aagaaacaat   3180 
               
               
                   
               
               
                 gaagactgaa ttaaattaaa aatgttgcag ctcataaaga attggactca cccctactgc   3240 
               
               
                   
               
               
                 actaccaaat tcatttgact ttggaggcaa aatgtgttga agtgccctat gaagtagcaa   3300 
               
               
                   
               
               
                 ttttctatag gaatatagtt ggaaataaat gtgtgtgtgt atattattat taatcaatgc   3360 
               
               
                   
               
               
                 aatatttaaa tgaaatgaga acaaagagga aaatggtaaa aacttgaaat gaggctgggg   3420 
               
               
                   
               
               
                 tatagtttgt cctacaatag aaaaaagaga gagcttccta ggcctgggct cttaaatgct   3480 
               
               
                   
               
               
                 gcattataac tgagtctatg aggaaatagt tcctgtccaa tttgtgtaat ttgtttaaaa   3540 
               
               
                   
               
               
                 ttgtaaataa at                                                       3552 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 127 
               
               
                 &lt;211&gt; LENGTH: 754 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 127 
               
               
                   
               
               
                 tttttttttt ttgtcattgt tcattgattt taatgagaaa gctaagagag gaaataagta     60 
               
               
                   
               
               
                 gcctttcaaa ggtcacacag aagtaagtga cagatccagg attcatatcc aagcattctg    120 
               
               
                   
               
               
                 gctctagtgt ccatgcttct caaccattat gacccaatat tcaaccaaat caatactgaa    180 
               
               
                   
               
               
                 ggacacgtga aatgtatccg gtattttact attacaaaca aaaatccaat gaacattctt    240 
               
               
                   
               
               
                 gaagacatac acaaaaataa tggttacaat agaagttact ggaattgaaa ttttggttca    300 
               
               
                   
               
               
                 acctatatta aaatgtaagg cttttgatat agctaataga tttttgaaat gatcagtctt    360 
               
               
                   
               
               
                 aacgtttgta ggggagcaca ctcctgcatg gggaaaagat tcactgtgaa gcacagagca    420 
               
               
                   
               
               
                 cctttatggt tggatcatct tgtcattaaa gttcaggcgt tatctatcct gtaagtggca    480 
               
               
                   
               
               
                 gaatcaagac tgcaatatcg cctgcttttc tttttaactc atgttttccc ttgactacac    540 
               
               
                   
               
               
                 tggtcctcaa agtaaaaccc ctgtgtcagt gtactattca tggaatactc tgcaattata    600 
               
               
                   
               
               
                 accaccttct aatactttta atacccaatc aaaatttatt atacatatgt atcatagata    660 
               
               
                   
               
               
                 ctcatctgta aagctgtgct tcaaaatagt gatctcttcc caacattaca atatatatta    720 
               
               
                   
               
               
                 atgatgtcga acctgcccgg gcggccgctc gaag                                754 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 128 
               
               
                 &lt;211&gt; LENGTH: 374 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 128 
               
               
                   
               
               
                 aggttttgat taaaaaggca aatgatttta ttgttcgata atcttttaaa aaaataagag     60 
               
               
                   
               
               
                 gaaggagtaa aattaaagat gaaagatgat ttttatttcc ttgtgacctc tatatccccc    120 
               
               
                   
               
               
                 ttcccctgcc cttggtaagt aactcttgat ggagaaagga ttaaagactc ttatttaacc    180 
               
               
                   
               
               
                 aaaaaacaga gccagctaat catttccaaa ggttagtatc tccctgctga cctcttcttt    240 
               
               
                   
               
               
                 ggtttaattg aataaaacta tatgttcata tatgtattaa aacaactcag aataacatct    300 
               
               
                   
               
               
                 tttcttcctt agttaaggca ttataagggc tatactatca tccataataa ccaaggcaat    360 
               
               
                   
               
               
                 aacttaaaaa gctg                                                      374 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 129 
               
               
                 &lt;211&gt; LENGTH: 546 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 129 
               
               
                   
               
               
                 agtgtgatgg atatctgcag aattcgggct aagcgtggtc gcggcccgag gtctggaact     60 
               
               
                   
               
               
                 tcccagcacy tgaaaaggag cctcctgagc tgactcggct aaagccccac tttcgctcct    120 
               
               
                   
               
               
                 cctcatttct gcctactgat ttccttggag cattcatctg aatattaccg tttgctgtgt    180 
               
               
                   
               
               
                 aacctggtac atacatagca tgactccctg gaatagagtg ggctggggtg cttatgctgg    240 
               
               
                   
               
               
                 gagagtgatt gacatgcact ttcaagctat atctaccatt tgcagcaaag gagaaaaaat    300 
               
               
                   
               
               
                 acctcgagta aattccatca ttttttataa catcagcacc tgctccatca tcaaggagtc    360 
               
               
                   
               
               
                 tcagcgtaac aggatctcca gtctctggct caactgtggc agtgacagtg gcattaagaa    420 
               
               
                   
               
               
                 tgggataaaa tccctgtttc acattggcat aaatcatcac aggatgagga aaatggaggc    480 
               
               
                   
               
               
                 tgtctctttc cacaaaggct tccacagtgg ctgggggcac agacctgccc gggcggccgc    540 
               
               
                   
               
               
                 tcgaaa                                                               546 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 130 
               
               
                 &lt;211&gt; LENGTH: 5156 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 130 
               
               
                   
               
               
                 accaaccgag gcgccgggca gcgacccctg cagcggagac agagactgag cggcccggca     60 
               
               
                   
               
               
                 ccgccatgcc tgcgctctgg ctgggctgct gcctctgctt gtcgctcctc ctgcccgcag    120 
               
               
                   
               
               
                 cccgggccac ctccaggagg gaagtctgtg attgcaatgg gaagtccagg cagtgtatct    180 
               
               
                   
               
               
                 ttgatcggga acttcacaga caaactggta atggattccg ctgcctcaac tgcaatgaca    240 
               
               
                   
               
               
                 acactgatgg cattcactgc gagaagtgca agaatggctt ttaccggcac agagaaaggg    300 
               
               
                   
               
               
                 accgctgttt gccctgcaat tgtaactcca aaggttctct tagtgctcga tgtgacaact    360 
               
               
                   
               
               
                 ccggacggtg cagctgtaaa ccaggtgtga caggagccag atgcgaccga tgtctgccag    420 
               
               
                   
               
               
                 gcttccacat gctcacggat gcggggtgca cccaagacca gagactgcta gactccaagt    480 
               
               
                   
               
               
                 gtgactgtga cccagctggc atcgcagggc cctgtgacgc gggccgctgt gtctgcaagc    540 
               
               
                   
               
               
                 cagctgtcac tggagaacgc tgtgataggt gtcgatcagg ttactataat ctggatgggg    600 
               
               
                   
               
               
                 ggaaccctga gggctgtacc cagtgtttct gctatgggca ttcagccagc tgccgcagct    660 
               
               
                   
               
               
                 ctgcagaata cagtgtccat aagatcacct ctacctttca tcaagatgtt gatggctgga    720 
               
               
                   
               
               
                 aggctgtcca acgaaatggg tctcctgcaa agctccaatg gtcacagcgc catcaagatg    780 
               
               
                   
               
               
                 tgtttagctc agcccaacga ctagaccctg tctattttgt ggctcctgcc aaatttcttg    840 
               
               
                   
               
               
                 ggaatcaaca ggtgagctat ggtcaaagcc tgtcctttga ctaccgtgtg gacagaggag    900 
               
               
                   
               
               
                 gcagacaccc atctgcccat gatgtgattc tggaaggtgc tggtctacgg atcacagctc    960 
               
               
                   
               
               
                 ccttgatgcc acttggcaag acactgcctt gtgggctcac caagacttac acattcaggt   1020 
               
               
                   
               
               
                 taaatgagca tccaagcaat aattggagcc cccagctgag ttactttgag tatcgaaggt   1080 
               
               
                   
               
               
                 tactgcggaa tctcacagcc ctccgcatcc gagctacata tggagaatac agtactgggt   1140 
               
               
                   
               
               
                 acattgacaa tgtgaccctg atttcagccc gccctgtctc tggagcccca gcaccctggg   1200 
               
               
                   
               
               
                 ttgaacagtg tatatgtcct gttgggtaca aggggcaatt ctgccaggat tgtgcttctg   1260 
               
               
                   
               
               
                 gctacaagag agattcagcg agactggggc cttttggcac ctgtattcct tgtaactgtc   1320 
               
               
                   
               
               
                 aagggggagg ggcctgtgat ccagacacag gagattgtta ttcaggggat gagaatcctg   1380 
               
               
                   
               
               
                 acattgagtg tgctgactgc ccaattggtt tctacaacga tccgcacgac ccccgcagct   1440 
               
               
                   
               
               
                 gcaagccatg tccctgtcat aacgggttca gctgctcagt gatgccggag acggaggagg   1500 
               
               
                   
               
               
                 tggtgtgcaa taactgccct cccggggtca ccggtgcccg ctgtgagctc tgtgctgatg   1560 
               
               
                   
               
               
                 gctactttgg ggaccccttt ggtgaacatg gcccagtgag gccttgtcag ccctgtcaat   1620 
               
               
                   
               
               
                 gcaacaacaa tgtggacccc agtgcctctg ggaattgtga ccggctgaca ggcaggtgtt   1680 
               
               
                   
               
               
                 tgaagtgtat ccacaacaca gccggcatct actgcgacca gtgcaaagca ggctacttcg   1740 
               
               
                   
               
               
                 gggacccatt ggctcccaac ccagcagaca agtgtcgagc ttgcaactgt aaccccatgg   1800 
               
               
                   
               
               
                 gctcagagcc tgtaggatgt cgaagtgatg gcacctgtgt ttgcaagcca ggatttggtg   1860 
               
               
                   
               
               
                 gccccaactg tgagcatgga gcattcagct gtccagcttg ctataatcaa gtgaagattc   1920 
               
               
                   
               
               
                 agatggatca gtttatgcag cagcttcaga gaatggaggc cctgatttca aaggctcagg   1980 
               
               
                   
               
               
                 gtggtgatgg agtagtacct gatacagagc tggaaggcag gatgcagcag gctgagcagg   2040 
               
               
                   
               
               
                 cccttcagga cattctgaga gatgcccaga tttcagaagg tgctagcaga tcccttggtc   2100 
               
               
                   
               
               
                 tccagttggc caaggtgagg agccaagaga acagctacca gagccgcctg gatgacctca   2160 
               
               
                   
               
               
                 agatgactgt ggaaagagtt cgggctctgg gaagtcagta ccagaaccga gttcgggata   2220 
               
               
                   
               
               
                 ctcacaggct catcactcag atgcagctga gcctggcaga aagtgaagct tccttgggaa   2280 
               
               
                   
               
               
                 acactaacat tcctgcctca gaccactacg tggggccaaa tggctttaaa agtctggctc   2340 
               
               
                   
               
               
                 aggaggccac aagattagca gaaagccacg ttgagtcagc cagtaacatg gagcaactga   2400 
               
               
                   
               
               
                 caagggaaac tgaggactat tccaaacaag ccctctcact ggtgcgcaag gccctgcatg   2460 
               
               
                   
               
               
                 aaggagtcgg aagcggaagc ggtagcccgg acggtgctgt ggtgcaaggg cttgtggaaa   2520 
               
               
                   
               
               
                 aattggagaa aaccaagtcc ctggcccagc agttgacaag ggaggccact caagcggaaa   2580 
               
               
                   
               
               
                 ttgaagcaga taggtcttat cagcacagtc tccgcctcct ggattcagtg tctcggcttc   2640 
               
               
                   
               
               
                 agggagtcag tgatcagtcc tttcaggtgg aagaagcaaa gaggatcaaa caaaaagcgg   2700 
               
               
                   
               
               
                 attcactctc aagcctggta accaggcata tggatgagtt caagcgtaca cagaagaatc   2760 
               
               
                   
               
               
                 tgggaaactg gaaagaagaa gcacagcagc tcttacagaa tggaaaaagt gggagagaga   2820 
               
               
                   
               
               
                 aatcagatca gctgctttcc cgtgccaatc ttgctaaaag cagagcacaa gaagcactga   2880 
               
               
                   
               
               
                 gtatgggcaa tgccactttt tatgaagttg agagcatcct taaaaacctc agagagtttg   2940 
               
               
                   
               
               
                 acctgcaggt ggacaacaga aaagcagaag ctgaagaagc catgaagaga ctctcctaca   3000 
               
               
                   
               
               
                 tcagccagaa ggtttcagat gccagtgaca agacccagca agcagaaaga gccctgggga   3060 
               
               
                   
               
               
                 gcgctgctgc tgatgcacag agggcaaaga atggggccgg ggaggccctg gaaatctcca   3120 
               
               
                   
               
               
                 gtgagattga acaggagatt gggagtctga acttggaagc caatgtgaca gcagatggag   3180 
               
               
                   
               
               
                 ccttggccat ggaaaaggga ctggcctctc tgaagagtga gatgagggaa gtggaaggag   3240 
               
               
                   
               
               
                 agctggaaag gaaggagctg gagtttgaca cgaatatgga tgcagtacag atggtgatta   3300 
               
               
                   
               
               
                 cagaagccca gaaggttgat accagagcca agaacgctgg ggttacaatc caagacacac   3360 
               
               
                   
               
               
                 tcaacacatt agacggcctc ctgcatctga tggaccagcc tctcagtgta gatgaagagg   3420 
               
               
                   
               
               
                 ggctggtctt actggagcag aagctttccc gagccaagac ccagatcaac agccaactgc   3480 
               
               
                   
               
               
                 ggcccatgat gtcagagctg gaagagaggg cacgtcagca gaggggccac ctccatttgc   3540 
               
               
                   
               
               
                 tggagacaag catagatggg attctggctg atgtgaagaa cttggagaac attagggaca   3600 
               
               
                   
               
               
                 acctgccccc aggctgctac aatacccagg ctcttgagca acagtgaagc tgccataaat   3660 
               
               
                   
               
               
                 atttctcaac tgaggttctt gggatacaga tctcagggct cgggagccat gtcatgtgag   3720 
               
               
                   
               
               
                 tgggtgggat ggggacattt gaacatgttt aatgggtatg ctcaggtcaa ctgacctgac   3780 
               
               
                   
               
               
                 cccattcctg atcccatggc caggtggttg tcttattgca ccatactcct tgcttcctga   3840 
               
               
                   
               
               
                 tgctgggcaa tgaggcagat agcactgggt gtgagaatga tcaaggatct ggaccccaaa   3900 
               
               
                   
               
               
                 gaatagactg gatggaaaga caaactgcac aggcagatgt ttgcctcata atagtcgtaa   3960 
               
               
                   
               
               
                 gtggagtcct ggaatttgga caagtgctgt tgggatatag tcaacttatt ctttgagtaa   4020 
               
               
                   
               
               
                 tgtgactaaa ggaaaaaact ttgactttgc ccaggcatga aattcttcct aatgtcagaa   4080 
               
               
                   
               
               
                 cagagtgcaa cccagtcaca ctgtggccag taaaatacta ttgcctcata ttgtcctctg   4140 
               
               
                   
               
               
                 caagcttctt gctgatcaga gttcctccta cttacaaccc agggtgtgaa catgttctcc   4200 
               
               
                   
               
               
                 attttcaagc tggaagaagt gagcagtgtt ggagtgagga cctgtaaggc aggcccattc   4260 
               
               
                   
               
               
                 agagctatgg tgcttgctgg tgcctgccac cttcaagttc tggacctggg catgacatcc   4320 
               
               
                   
               
               
                 tttcttttaa tgatgccatg gcaacttaga gattgcattt ttattaaagc atttcctacc   4380 
               
               
                   
               
               
                 agcaaagcaa atgttgggaa agtatttact ttttcggttt caaagtgata gaaaagtgtg   4440 
               
               
                   
               
               
                 gcttgggcat tgaaagaggt aaaattctct agatttatta gtcctaattc aatcctactt   4500 
               
               
                   
               
               
                 ttagaacacc aaaaatgatg cgcatcaatg tattttatct tattttctca atctcctctc   4560 
               
               
                   
               
               
                 tctttcctcc acccataata agagaatgtt cctactcaca cttcagctgg gtcacatcca   4620 
               
               
                   
               
               
                 tccctccatt catccttcca tccatctttc catccattac ctccatccat ccttccaaca   4680 
               
               
                   
               
               
                 tatatttatt gagtacctac tgtgtgccag gggctggtgg gacagtggtg acatagtctc   4740 
               
               
                   
               
               
                 tgccctcata gagttgattg tctagtgagg aagacaagca tttttaaaaa ataaatttaa   4800 
               
               
                   
               
               
                 acttacaaac tttgtttgtc acaagtggtg tttattgcaa taaccgcttg gtttgcaacc   4860 
               
               
                   
               
               
                 tctttgctca acagaacata tgttgcaaga ccctcccatg ggggcacttg agttttggca   4920 
               
               
                   
               
               
                 aggctgacag agctctgggt tgtgcacatt tctttgcatt ccagctgtca ctctgtgcct   4980 
               
               
                   
               
               
                 ttctacaact gattgcaaca gactgttgag ttatgataac accagtggga attgctggag   5040 
               
               
                   
               
               
                 gaaccagagg cacttccacc ttggctggga agactatggt gctgccttgc ttctgtattt   5100 
               
               
                   
               
               
                 ccttggattt tcctgaaagt gtttttaaat aaagaacaat tgttagaaaa aaaaaa       5156 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 131 
               
               
                 &lt;211&gt; LENGTH: 671 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 131 
               
               
                   
               
               
                 aggtctggag ggcccacagc cggatgtggg acaccgggaa aaagtggtca tagcacacat     60 
               
               
                   
               
               
                 ttttgcatcc cggttgcagt gtgttgcaga cgaagtcctc ttgctcgtca ccccacactt    120 
               
               
                   
               
               
                 cctgggcagc caycacgagg atcatgactc ggaaaataaa gatgactgtg atccacacct    180 
               
               
                   
               
               
                 tcccgatgct ggtggagtgt ttgttgacac ccccgatgaa agtgtgcagc gtcccccaat    240 
               
               
                   
               
               
                 ccattgcgct ggtttatccc tgagtcctgt ttccaacgac tgccagtgtt tcagacccaa    300 
               
               
                   
               
               
                 agaatgaggg caagatccct ctgcgagggt ttcagacctc cttctcctac cccactggag    360 
               
               
                   
               
               
                 tgcctagaag ccaatgggtg cacagtgatg atacgaatgt caatctttgc tcggtcagtg    420 
               
               
                   
               
               
                 aggatgtcgc ctggaatatt caaattgaat tacagatgca tgaagagggc gtacaagtta    480 
               
               
                   
               
               
                 gaatttttct ttcgccatac agaaattgtt tagccagatc ttctgtactt cttttccttc    540 
               
               
                   
               
               
                 cctgaccctt cctgctcccc aggaagggag gtcagccccg tttgcaaaac acaggatgcc    600 
               
               
                   
               
               
                 cgtgacaccg gagacaggtc ttcttcaccg acaggaagtg ccttctggtg cctgcacgtt    660 
               
               
                   
               
               
                 ttaactgcta t                                                         671 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 132 
               
               
                 &lt;211&gt; LENGTH: 590 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 132 
               
               
                   
               
               
                 ctgaatggaa aagcttatgg ctctgtgatg atattagtga ccagcggaga tgataagctt     60 
               
               
                   
               
               
                 cttggcaatt gcttacccac tgtgctcagc agtggttcaa caattcactc cattgccctg    120 
               
               
                   
               
               
                 ggttcatctg cagccccaaa tctggaggaa ttatcacgtc ttacaggagg tttaaagttc    180 
               
               
                   
               
               
                 tttgttccag atatatcaaa ctccaatagc atgattgatg ctttcagtag aatttcctct    240 
               
               
                   
               
               
                 ggaactggag acattttcca gcaacatatt cagcttgaaa gtacaggtga aaatgtcaaa    300 
               
               
                   
               
               
                 cctcaccatc aattgaaaaa cacagtgact gtggataata ctgtgggcaa cgacactatg    360 
               
               
                   
               
               
                 tttctagtta cgtggcaggc cagtggtcct cctgagatta tattatttga tcctgatgga    420 
               
               
                   
               
               
                 cgaaaatact acacaaataa ttttatcacc aatctaactt ttcggacagc tagtctttgg    480 
               
               
                   
               
               
                 attccaggaa cagctaagcc tgggcactgg acttacaccc tgaacaatac ccatcattct    540 
               
               
                   
               
               
                 ctgcaagccc tgaaagtgac agtgacctct cgcgcctcca actcagacct               590 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 133 
               
               
                 &lt;211&gt; LENGTH: 581 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 133 
               
               
                   
               
               
                 aggtcctgtc cgggggcact gagaactccc tctggaattc ttggggggtg ttggggagag     60 
               
               
                   
               
               
                 actgtgggcc tggagataaa acttgtctcc tctaccacca ccctgtaccc tagcctgcac    120 
               
               
                   
               
               
                 ctgtcctcat ctctgcaaag ttcagcttcc ttccccaggt ctctgtgcac tctgtcttgg    180 
               
               
                   
               
               
                 atgctctggg gagctcatgg gtggaggagt ctccaccaga gggaggctca ggggactggt    240 
               
               
                   
               
               
                 tgggccaggg atgaatattt gagggataaa aattgtgtaa gagccaaaga attggtagta    300 
               
               
                   
               
               
                 gggggagaac agagaggagc tgggctatgg gaaatgattt gaataatgga gctgggaata    360 
               
               
                   
               
               
                 tggctggata tctggtacta aaaaagggtc tttaagaacc tacttcctaa tctcttcccc    420 
               
               
                   
               
               
                 aatccaaacc atagctgtct gtccagtgct ctcttcctgc ctccagctct gccccaggct    480 
               
               
                   
               
               
                 cctcctagac tctgtccctg ggctagggca ggggaggagg gagagcaggg ttgggggaga    540 
               
               
                   
               
               
                 ggctgaggag agtgtgacat gtggggagag gaccagacct c                        581 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 134 
               
               
                 &lt;211&gt; LENGTH: 4797 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (135) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (501) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (4421) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (4467) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (4468) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (4698) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 134 
               
               
                   
               
               
                 cctgggacca aagtgctgcc cagagctgag ggtcctggag ccacatgaga aggcttctcc     60 
               
               
                   
               
               
                 ctgtgtacct gtgcagcaca gggtagggtg agtccactca gctgtctagg agaggaccca    120 
               
               
                   
               
               
                 ggagcagcag agacncgcca agcctttact cataccatat tctgatcctt ttccagcaaa    180 
               
               
                   
               
               
                 ttgtggctac taatttgccc cctgaagatc aagatggctc tggggatgac tctgacaact    240 
               
               
                   
               
               
                 tctccggctc aggtgcaggt gaggttgtca tgggggcccc ccccacccaa gacggcaaca    300 
               
               
                   
               
               
                 ggtcatgcct gggggcagtg gtcaggcagt ctcctgtgtt tactgagcat gtactgagtg    360 
               
               
                   
               
               
                 caccctgcct gccctgtctc cacccagctg gctccaaagg gcaatgctga ggagaggaat    420 
               
               
                   
               
               
                 ggggtcgtga gctgctgtta aggagagctc atgcttggag gtgaggtgaa ggctgtgagc    480 
               
               
                   
               
               
                 tccagaaggc cccagggcgc nctgctgcac gcaggctcat attcactagg aatagcttta    540 
               
               
                   
               
               
                 ctcactaaga aacctctgga acccccttca gaaggttatt tgactcctga gcctctattt    600 
               
               
                   
               
               
                 tctcatctgc aaaatgggaa taataccttg acctgataag cttgtggagc tgtaaggcag    660 
               
               
                   
               
               
                 cacagagcca gctggggtgt agctcttcca tccaagctcc cttccttact tcccctttcc    720 
               
               
                   
               
               
                 tgtggggact gggggagaga agtccctgag ctggaggtgg tcagggaagc ttcacagagg    780 
               
               
                   
               
               
                 aggtggctct tgagtggacc tcaggaagag gggtgagaga gctaaggaag gaggctgagg    840 
               
               
                   
               
               
                 tcatccctgg ggaagtgacc tagcggaggc ctgagagctg caaggtagga tatctgttgt    900 
               
               
                   
               
               
                 tggaagtgtc tgttgttgga agtgggggcc tttttttcag ggagggtggg gccagagaag    960 
               
               
                   
               
               
                 tgtgtgccct gggataagta ggataaccac agtagttatg cccctaaggg atgcccaccc   1020 
               
               
                   
               
               
                 cacccctgtg gtcacagaaa agctttccca ggtggcctag gcacctgtct cgtggctcca   1080 
               
               
                   
               
               
                 gagacaggct gcacctgaca cacacaatgg aaggacagct ctccttgtcc attttccaag   1140 
               
               
                   
               
               
                 gagcttagcc tcagctgcct tgtccaggta ctagcctccc tcatagcctg agcttggcca   1200 
               
               
                   
               
               
                 gcccaggtgc tctggagcct cccccgaccc acccaacaca ctctgcttct ggtcctcccc   1260 
               
               
                   
               
               
                 accccccacc tccccaacac actctgcttc tggtcctgca ggtgctttgc aagatatcac   1320 
               
               
                   
               
               
                 cttgtcacag cagaccccct ccacttggaa ggacacgcag ctcctgacgg ctattcccac   1380 
               
               
                   
               
               
                 gtctccagaa cccaccggcc tggaggctac agctgcctcc acctccaccc tgccggctgg   1440 
               
               
                   
               
               
                 agaggggccc aaggagggag aggctgtagt cctgccagaa gtggagcctg gcctcaccgc   1500 
               
               
                   
               
               
                 ccgggagcag gaggccaccc cccgacccag ggagaccaca cagctcccga ccactcatca   1560 
               
               
                   
               
               
                 ggcctcaacg accacagcca ccacggccca ggagcccgcc acctcccacc cccacaggga   1620 
               
               
                   
               
               
                 catgcagcct ggccaccatg agacctcaac ccctgcagga cccagccaag ctgaccttca   1680 
               
               
                   
               
               
                 cactccccac acagaggatg gaggtccttc tgccaccgag agggctgctg aggatggagc   1740 
               
               
                   
               
               
                 ctccagtcag ctcccagcag cagagggctc tggggagcag gtgagtggcc tctgcattcc   1800 
               
               
                   
               
               
                 ttgggaaatt gagtgggttg gtcctaatgc ctggcacttg gcaggcccta cacctgtgcc   1860 
               
               
                   
               
               
                 ctgcgcgatc tcgtattcct caccaggaag acagggcaca ggggccgcct tcccctaccc   1920 
               
               
                   
               
               
                 ccagggcctc gcagagcagg acagactaac tatgagatca gagcagaagc acccttaaag   1980 
               
               
                   
               
               
                 atcacccaag agagggctcc caaactcaca atccaaactt gcagccctcg tcgaagagtg   2040 
               
               
                   
               
               
                 aacgttatac cagtcatttt atttatagct tcgtggattt acgcttacac taaatagtct   2100 
               
               
                   
               
               
                 gctattcata caaaatgtgt gctttgtatc actttttgtg atatccatgc catggtccag   2160 
               
               
                   
               
               
                 ccagggtccg gagttgatgt ggcaagaagg cctggctttc gggccctgtg cgatcctggt   2220 
               
               
                   
               
               
                 ttgggtgcat ctgagtgggt ggtggcaaag atcagggagg caggagctgc ttctgggtct   2280 
               
               
                   
               
               
                 gtagtggagc tggttgctgc tgctggcggt gacctggcca acccaatctg cccctgccct   2340 
               
               
                   
               
               
                 cccacaggac ttcacctttg aaacctcggg ggagaatacg gctgtagtgg ccgtggagcc   2400 
               
               
                   
               
               
                 tgaccgccgg aaccagtccc cagtggatca gggggccacg ggggcctcac agggcctcct   2460 
               
               
                   
               
               
                 ggacaggaaa gaggtgctgg gaggtgagtt ttctttcagg ggggtagttt ggggtgaatt   2520 
               
               
                   
               
               
                 gctgctgtgg ggtcagggtg gggctgacca cagccaaggc cactgctttg ggagggtctg   2580 
               
               
                   
               
               
                 cacgagagcc caaggagccg ctgagctgag ctggccccgt ctacctgccc taggggtcat   2640 
               
               
                   
               
               
                 tgccggaggc ctcgtggggc tcatctttgc tgtgtgcctg gtgggtttca tgctgtaccg   2700 
               
               
                   
               
               
                 catgaagaag aaggacgaag gcagctactc cttggaggag ccgaaacaag ccaacggcgg   2760 
               
               
                   
               
               
                 ggcctaccag aagcccacca aacaggagga attctatgcc tgacgcggga gccatgcgcc   2820 
               
               
                   
               
               
                 ccctccgccc tgccactcac taggccccca cttgcctctt ccttgaagaa ctgcaggccc   2880 
               
               
                   
               
               
                 tggcctcccc tgccaccagg ccacctcccc agcattccag cccctctggt cgctcctgcc   2940 
               
               
                   
               
               
                 cacggagtcg tgggtgtgct gggagctcca ctctgcttct ctgacttctg cctggagact   3000 
               
               
                   
               
               
                 tagggcacca ggggtttctc gcataggacc tttccaccac agccagcacc tggcatcgca   3060 
               
               
                   
               
               
                 ccattctgac tcggtttctc caaactgaag cagcctctcc ccaggtccag ctctggaggg   3120 
               
               
                   
               
               
                 gagggggatc cgactgcttt ggacctaaat ggcctcatgt ggctggaaga tcctgcgggt   3180 
               
               
                   
               
               
                 ggggcttggg gctcacacac ctgtagcact tactggtagg accaagcatc ttgggggggt   3240 
               
               
                   
               
               
                 ggccgctgag tggcagggga caggagtcac tttgtttcgt ggggaggtct aatctagata   3300 
               
               
                   
               
               
                 tcgacttgtt tttgcacatg tttcctctag ttctttgttc atagcccagt agaccttgtt   3360 
               
               
                   
               
               
                 acttctgagg taagttaagt aagttgattc ggtatccccc catcttgctt ccctaatcta   3420 
               
               
                   
               
               
                 tggtcgggag acagcatcag ggttaagaag actttttttt ttttttttaa actaggagaa   3480 
               
               
                   
               
               
                 ccaaatctgg aagccaaaat gtaggcttag tttgtgtgtt gtctcttgag tttgtcgctc   3540 
               
               
                   
               
               
                 atgtgtgcaa cagggtatgg actatctgtc tggtggcccc gttctggtgg tctgttggca   3600 
               
               
                   
               
               
                 ggctggccag tccaggctgc cgtggggccg ccgcctcttt caagcagtcg tgcctgtgtc   3660 
               
               
                   
               
               
                 catgcgctca gggccatgct gaggcctggg ccgctgccac gttggagaag cccgtgtgag   3720 
               
               
                   
               
               
                 aagtgaatgc tgggactcag ccttcagaca gagaggactg tagggagggc ggcaggggcc   3780 
               
               
                   
               
               
                 tggagatcct cctgcaggct cacgcccgtc ctcctgtggc gccgtctcca ggggctgctt   3840 
               
               
                   
               
               
                 cctcctggaa attgacgagg ggtgtcttgg gcagagctgg ctctgagcgc ctccatccaa   3900 
               
               
                   
               
               
                 ggccaggttc tccgttagct cctgtggccc caccctgggc cctgggctgg aatcaggaat   3960 
               
               
                   
               
               
                 attttccaaa gagtgatagt cttttgcttt tggcaaaact ctacttaatc caatgggttt   4020 
               
               
                   
               
               
                 ttccctgtac agtagatttt ccaaatgtaa taaactttaa tataaagtag tctgtgaatg   4080 
               
               
                   
               
               
                 ccactgcctt cgcttcttgc ctctgtgctg tgtgtgacgt gaccggactt ttctgcaaac   4140 
               
               
                   
               
               
                 accaacatgt tgggaaactt ggctcgaatc tctgtgcctt cgtctttccc atggggaggg   4200 
               
               
                   
               
               
                 attctggttc cagggtccct ctgtgtattt gcttttttgt tttggctgaa attctcctgg   4260 
               
               
                   
               
               
                 aggtcggtag gttcagccaa ggttttataa ggctgatgtc aatttctgtg ttgccaagct   4320 
               
               
                   
               
               
                 ccaagcccat cttctaaatg gcaaaggaag gtggatggcc ccagcacagc ttgacctgag   4380 
               
               
                   
               
               
                 gctgtggtca cagcggaggt gtggagccga ggcctacccc ncagacacct tggacatcct   4440 
               
               
                   
               
               
                 cctcccaccc ggctgcagag gccaganncc agcccagggt cctgcactta cttgcttatt   4500 
               
               
                   
               
               
                 tgacaacgtt tcagcgactc cgttggccac tccgagagtg ggccagtctg tggatcagag   4560 
               
               
                   
               
               
                 atgcaccacc aagccaaggg aacctgtgtc cggtattcga tactgcgact ttctgcctgg   4620 
               
               
                   
               
               
                 agtgtatgac tgcacatgac tcgggggtgg ggaaaggggt cggctgacca tgctcatctg   4680 
               
               
                   
               
               
                 ctggtccgtg ggacggtncc caagccagag gtgggttcat ttgtgtaacg acaataaacg   4740 
               
               
                   
               
               
                 gtacttgtca tttcgggcaa cggctgctgt ggtggtggtt gagtctcttc ttggcct      4797 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 135 
               
               
                 &lt;211&gt; LENGTH: 2856 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 135 
               
               
                   
               
               
                 tagtcgcggg tccccgagtg agcacgccag ggagcaggag accaaacgac gggggtcgga     60 
               
               
                   
               
               
                 gtcagagtcg cagtgggagt ccccggaccg gagcacgagc ctgagcggga gagcgccgct    120 
               
               
                   
               
               
                 cgcacgcccg tcgccacccg cgtacccggc gcagccagag ccaccagcgc agcgctgcca    180 
               
               
                   
               
               
                 tggagcccag cagcaagaag ctgacgggtc gcctcatgct ggctgtggga ggagcagtgc    240 
               
               
                   
               
               
                 ttggctccct gcagtttggc tacaacactg gagtcatcaa tgccccccag aaggtgatcg    300 
               
               
                   
               
               
                 aggagttcta caaccagaca tgggtccacc gctatgggga gagcatcctg cccaccacgc    360 
               
               
                   
               
               
                 tcaccacgct ctggtccctc tcagtggcca tcttttctgt tgggggcatg attggctcct    420 
               
               
                   
               
               
                 tctctgtggg ccttttcgtt aaccgctttg gccggcggaa ttcaatgctg atgatgaacc    480 
               
               
                   
               
               
                 tgctggcctt cgtgtccgcc gtgctcatgg gcttctcgaa actgggcaag tcctttgaga    540 
               
               
                   
               
               
                 tgctgatcct gggccgcttc atcatcggtg tgtactgcgg cctgaccaca ggcttcgtgc    600 
               
               
                   
               
               
                 ccatgtatgt gggtgaagtg tcacccacag cctttcgtgg ggccctgggc accctgcacc    660 
               
               
                   
               
               
                 agctgggcat cgtcgtcggc atcctcatcg cccaggtgtt cggcctggac tccatcatgg    720 
               
               
                   
               
               
                 gcaacaagga cctgtggccc ctgctgctga gcatcatctt catcccggcc ctgctgcagt    780 
               
               
                   
               
               
                 gcatcgtgct gcccttctgc cccgagagtc cccgcttcct gctcatcaac cgcaacgagg    840 
               
               
                   
               
               
                 agaaccgggc caagagtgtg ctaaagaagc tgcgcgggac agctgacgtg acccatgacc    900 
               
               
                   
               
               
                 tgcaggagat gaaggaagag agtcggcaga tgatgcggga gaagaaggtc accatcctgg    960 
               
               
                   
               
               
                 agctgttccg ctcccccgcc taccgccagc ccatcctcat cgctgtggtg ctgcagctgt   1020 
               
               
                   
               
               
                 cccagcagct gtctggcatc aacgctgtct tctattactc cacgagcatc ttcgagaagg   1080 
               
               
                   
               
               
                 cgggggtgca gcagcctgtg tatgccacca ttggctccgg tatcgtcaac acggccttca   1140 
               
               
                   
               
               
                 ctgtcgtgtc gctgtttgtg gtggagcgag caggccggcg gaccctgcac ctcataggcc   1200 
               
               
                   
               
               
                 tcgctggcat ggcgggttgt gccatactca tgaccatcgc gctagcactg ctggagcagc   1260 
               
               
                   
               
               
                 taccctggat gtcctatctg agcatcgtgg ccatctttgg ctttgtggcc ttctttgaag   1320 
               
               
                   
               
               
                 tgggtcctgg ccccatccca tggttcatcg tggctgaact cttcagccag ggtccacgtc   1380 
               
               
                   
               
               
                 cagctgccat tgccgttgca ggcttctcca actggacctc aaatttcatt gtgggcatgt   1440 
               
               
                   
               
               
                 gcttccagta tgtggagcaa ctgtgtggtc cctacgtctt catcatcttc actgtgctcc   1500 
               
               
                   
               
               
                 tggttctgtt cttcatcttc acctacttca aagttcctga gactaaaggc cggaccttcg   1560 
               
               
                   
               
               
                 atgagatcgc ttccggcttc cggcaggggg gagccagcca aagtgataag acacccgagg   1620 
               
               
                   
               
               
                 agctgttcca tcccctgggg gctgattccc aagtgtgagt cgccccagat caccagcccg   1680 
               
               
                   
               
               
                 gcctgctccc agcagcccta aggatctctc aggagcacag gcagctggat gagacttcca   1740 
               
               
                   
               
               
                 aacctgacag atgtcagccg agccgggcct ggggctcctt tctccagcca gcaatgatgt   1800 
               
               
                   
               
               
                 ccagaagaat attcaggact taacggctcc aggattttaa caaaagcaag actgttgctc   1860 
               
               
                   
               
               
                 aaatctattc agacaagcaa caggttttat aattttttta ttactgattt tgttattttt   1920 
               
               
                   
               
               
                 atatcagcct gagtctcctg tgcccacatc ccaggcttca ccctgaatgg ttccatgcct   1980 
               
               
                   
               
               
                 gagggtggag actaagccct gtcgagacac ttgccttctt cacccagcta atctgtaggg   2040 
               
               
                   
               
               
                 ctggacctat gtcctaagga cacactaatc gaactatgaa ctacaaagct tctatcccag   2100 
               
               
                   
               
               
                 gaggtggcta tggccacccg ttctgctggc ctggatctcc ccactctagg ggtcaggctc   2160 
               
               
                   
               
               
                 cattaggatt tgccccttcc catctcttcc tacccaacca ctcaaattaa tctttcttta   2220 
               
               
                   
               
               
                 cctgagacca gttgggagca ctggagtgca gggaggagag gggaagggcc agtctgggct   2280 
               
               
                   
               
               
                 gccgggttct agtctccttt gcactgaggg ccacactatt accatgagaa gagggcctgt   2340 
               
               
                   
               
               
                 gggagcctgc aaactcactg ctcaagaaga catggagact cctgccctgt tgtgtataga   2400 
               
               
                   
               
               
                 tgcaagatat ttatatatat ttttggttgt caatattaaa tacagacact aagttatagt   2460 
               
               
                   
               
               
                 atatctggac aagccaactt gtaaatacac cacctcactc ctgttactta cctaaacaga   2520 
               
               
                   
               
               
                 tataaatggc tggtttttag aaacatggtt ttgaaatgct tgtggattga gggtaggagg   2580 
               
               
                   
               
               
                 tttggatggg agtgagacag aagtaagtgg ggttgcaacc actgcaacgg cttagacttc   2640 
               
               
                   
               
               
                 gactcaggat ccagtccctt acacgtacct ctcatcagtg tcctcttgct caaaaatctg   2700 
               
               
                   
               
               
                 tttgatccct gttacccaga gaatatatac attctttatc ttgacattca aggcatttct   2760 
               
               
                   
               
               
                 atcacatatt tgatagttgg tgttcaaaaa aacactagtt ttgtgccagc cgtgatgctc   2820 
               
               
                   
               
               
                 aggcttgaaa tcgcattatt ttgaatgtga agggaa                             2856 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 136 
               
               
                 &lt;211&gt; LENGTH: 356 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 136 
               
               
                   
               
               
                 ggtggagcca aatgaagaaa atgaagatga aagagacaga cacctcagtt tttctggatc     60 
               
               
                   
               
               
                 aggcattgat gatgatgaag attttatctc cagcaccatt tcaaccacac cacgggcttt    120 
               
               
                   
               
               
                 tgaccacaca aaacagaacc aggactggac tcagtggaac ccaagccatt caaatccgga    180 
               
               
                   
               
               
                 agtgctactt cagacaacca caaggatgac tgatgtagac agaaatggca ccactgctta    240 
               
               
                   
               
               
                 tgaaggaaac tggaacccag aagcacaccc tcccctcatt caccatgagc atcatgagga    300 
               
               
                   
               
               
                 agaagagacc ccacattcta caagcacaat ccaggcaact cctagtagta caacgg        356 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 137 
               
               
                 &lt;211&gt; LENGTH: 356 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (254) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (264) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (279) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (281) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (290) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (328) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (342) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 137 
               
               
                   
               
               
                 gcaggtggag aagacatttt attgttcctg gggtctctgg aggcccattg gtggggctgg     60 
               
               
                   
               
               
                 gtcactggct gcccccggaa cagggcgctg ctccatggct ctgcttgtgg tagtctgtgg    120 
               
               
                   
               
               
                 ctatgtctcc cagcaaggac agaaactcag aaaaatcaat cttcttatcc tcattcttgt    180 
               
               
                   
               
               
                 cctttttctc aaagacatcg gcgaggtaat ttgtgccctt tttacctcgg cccgcgacca    240 
               
               
                   
               
               
                 cgctaaggcc aaanttccag acanayggcc gggccggtnc nataggggan cccaacttgg    300 
               
               
                   
               
               
                 ggacccaaac tctggcgcgg aaacacangg gcataagctt gnttcctgtg gggaaa        356 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 138 
               
               
                 &lt;211&gt; LENGTH: 353 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 138 
               
               
                   
               
               
                 aggtccagtc ctccacttgg cctgatgaga gtggggagtg gcaagggacg tttctcctgc     60 
               
               
                   
               
               
                 aatagacact tagatttctc tcttgtggga agaaaccacc tgtccatcca ctgactcttc    120 
               
               
                   
               
               
                 tacattgatg tggaaattgc tgctgctacc accacctcct gaagaggctt ccctgatgcc    180 
               
               
                   
               
               
                 aatgccagcc atcttggcat cctggccctc gagcaggctg cggtaagtag cgatctcctg    240 
               
               
                   
               
               
                 ctccagccgt gtctttatgt caagcagcat cttgtactcc tggttctgag cctccatctc    300 
               
               
                   
               
               
                 gcatcggagc tcactcagac ctcgsccgsg mssmcgctam gccgaattcc agc           353 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 139 
               
               
                 &lt;211&gt; LENGTH: 371 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 139 
               
               
                   
               
               
                 agcgtggtcg cggccgaggt ccatccgaag caagattgca gatggcagtg tgaagagaga     60 
               
               
                   
               
               
                 agacatattc tacacttcaa agctttggtg caattcccat cgaccagagt tggtccgacc    120 
               
               
                   
               
               
                 agccttggaa aggtcactga aaaatcttca attggattat gttgacctct accttattca    180 
               
               
                   
               
               
                 ttttccagtg tctgtaaagc caggtgagga agtgatccca aaagatgaaa atggaaaaat    240 
               
               
                   
               
               
                 actatttgac acagtggatc tctgtgccac gtgggaggcc gtggagaagt gtaaagatgc    300 
               
               
                   
               
               
                 aggattggac ctgcccgggc ggccgctcga aagccgaatt ccagcacact ggcggccgtt    360 
               
               
                   
               
               
                 actagtggat c                                                         371 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 140 
               
               
                 &lt;211&gt; LENGTH: 370 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 140 
               
               
                   
               
               
                 tagcgtggtc gcggccgagg tccatctccc tttgggaact agggggctgc tggtgggaaa     60 
               
               
                   
               
               
                 tgggagccag ggcagatgtt gcattccttt gtgtccctgt aaatgtggga ctacaagaag    120 
               
               
                   
               
               
                 aggagctgcc tgagtggtac tttctcttcc tggtaatcct ctggcccagc ctcatggcag    180 
               
               
                   
               
               
                 aatagaggta tttttaggct atttttgtaa tatggcttct ggtcaaaatc cctgtgtagc    240 
               
               
                   
               
               
                 tgaattccca agccctgcat tgtacagccc cccactcccc tcaccaccta ataaaggaat    300 
               
               
                   
               
               
                 agttaacact caaaaaaaaa aaaaaacctg cccgggcggc cgctcgaaag ccgaattcca    360 
               
               
                   
               
               
                 gcacactggc                                                           370 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 141 
               
               
                 &lt;211&gt; LENGTH: 371 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 141 
               
               
                   
               
               
                 tagcgtggtc gcggccgagg tcctctgtgc tgcctgtcac agcccgatgg taccagcgca     60 
               
               
                   
               
               
                 gggtgtaggc agtgcaggag ccctcatcca gtggcaggga acaggggtca tcactatccc    120 
               
               
                   
               
               
                 aaggagcttc agggtcctgg tactcctcca cagaatactc ggagtattca gagtactcat    180 
               
               
                   
               
               
                 catcctcagg gggtacccgc tcttcctcct ctgcatgaga gacgcggagc acaggcacag    240 
               
               
                   
               
               
                 catggagctg ggagccggca gtgtctgcag cataactagg gaggggtcgt gatccagatg    300 
               
               
                   
               
               
                 cgatgaactg gccctggcag gcacagtgct gactcatctc ttggcgacct gcccgggcgg    360 
               
               
                   
               
               
                 ccgctcgaag c                                                         371 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 142 
               
               
                 &lt;211&gt; LENGTH: 343 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 142 
               
               
                   
               
               
                 gcgttttgag gccaatggtg taaaaggaaa tatcttcaca taaaaactag atggaagcat     60 
               
               
                   
               
               
                 tgtcagaaac ctctttgtga tgtttgcttt caactcacag agttgaacat tccttttcat    120 
               
               
                   
               
               
                 agagcagttt tgaaacactc ttttgtagaa tttgcaagcg gatgattgga tcgctatgag    180 
               
               
                   
               
               
                 gtcttcattg gaaacgggat acctttacat aaaaactaga cagtagcatt ctcagaaatt    240 
               
               
                   
               
               
                 tctttgggat gtgggcattc aacccacaga ggagaacttc atttgataga gcagttttga    300 
               
               
                   
               
               
                 aacacccttt ttgtagaatc tacaggtgga catttagagt gct                      343 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 143 
               
               
                 &lt;211&gt; LENGTH: 354 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 143 
               
               
                   
               
               
                 aggtctgatg gcagaaaaac tcagactgtc tgcaacttta cagatggtgc attggttcag     60 
               
               
                   
               
               
                 catcaggagt gggatgggaa ggaaagcaca ataacaagaa aattgaaaga tgggaaatta    120 
               
               
                   
               
               
                 gtggtggagt gtgtcatgaa caatgtcacc tgtactcgga tctatgaaaa agtagaataa    180 
               
               
                   
               
               
                 aaattccatc atcactttgg acaggagtta attaagagaa tgaccaagct cagttcaatg    240 
               
               
                   
               
               
                 agcaaatctc catactgttt ctttcttttt tttttcatta ctgtgttcaa ttatctttat    300 
               
               
                   
               
               
                 cataaacatt ttacatgcag ctatttcaaa gtgtgttgga ttaattagga tcat          354 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 144 
               
               
                 &lt;211&gt; LENGTH: 353 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 144 
               
               
                   
               
               
                 ggtcaaggac ctgggggacc cccaggtcca gcagccacat gattctgcag cagacaggga     60 
               
               
                   
               
               
                 cctagagcac atctggatct cagccccacc cctggcaacc tgcctgccta gagaactccc    120 
               
               
                   
               
               
                 aagatgacag actaagtagg attctgccat ttagaataat tctggtatcc tgggcgttgc    180 
               
               
                   
               
               
                 gttaagttgc ttaactttca ttctgtctta cgatagtctt cagaggtggg aacagatgaa    240 
               
               
                   
               
               
                 gaaaccatgc cccagagaag gttaagtgac ttcctcttta tggagccagt gttccaacct    300 
               
               
                   
               
               
                 aggtttgcct gataccagac ctgtggcccc acctcccatg caggtctctg tgg           353 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 145 
               
               
                 &lt;211&gt; LENGTH: 371 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 145 
               
               
                   
               
               
                 caggtctgtc ataaactggt ctggagtttc tgacgactcc ttgttcacca aatgcaccat     60 
               
               
                   
               
               
                 ttcctgagac ttgctggcct ctccgttgag tccacttggc tttctgtcct ccacagctcc    120 
               
               
                   
               
               
                 attgccactg ttgatcacta gctttttctt ctgcccacac cttcttcgac tgttgactgc    180 
               
               
                   
               
               
                 aatgcaaact gcaagaatca aagccaaggc caagagggat gccaagatga tcagccattc    240 
               
               
                   
               
               
                 tggaatttgg ggtgtcctta taggaccaga ggttgtgttt gctccacctt cttgactccc    300 
               
               
                   
               
               
                 atgtgagacc tcggccgcga ccacgctaag ccgaattcca gcacactggc ggcccgttac    360 
               
               
                   
               
               
                 tagtggatcc g                                                         371 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 146 
               
               
                 &lt;211&gt; LENGTH: 355 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 146 
               
               
                   
               
               
                 ggtcctccgt cctcttccca gaggtgtcgg ggcttggccc cagcctccat cttcgtctct     60 
               
               
                   
               
               
                 caggatggcg agtagcagcg gctccaaggc tgaattcatt gtcggaggga aatataaact    120 
               
               
                   
               
               
                 ggtacggaag atcgggtctg gctccttcgg ggacatctat ttggcgatca acatcaccaa    180 
               
               
                   
               
               
                 cggcgaggaa gtggcagtga agctagaatc tcagaaggcc aggcatcccc agttgctgta    240 
               
               
                   
               
               
                 cgagagcaag ctctataaga ttcttcaagg tggggttggc atcccccaca tacggtggta    300 
               
               
                   
               
               
                 tggtcaggaa aaagactaca atgtactagt catggatctt ctgggaccta gcctc         355 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 147 
               
               
                 &lt;211&gt; LENGTH: 355 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 147 
               
               
                   
               
               
                 ggtctgttac aaaatgaaga cagacaacac aacatttact ctgtggagat atcctactca     60 
               
               
                   
               
               
                 tactatgcac gtgctgtgat tttgaacata actcgtccca aaaacttgtc acgatcatcc    120 
               
               
                   
               
               
                 tgacttttta ggttggctga tccatcaatc ttgcactcaa ctgttacttc tttcccagtg    180 
               
               
                   
               
               
                 ttgttaggag caaagctgac ctgaacagca accaatggct gtagataccc aacatgcagt    240 
               
               
                   
               
               
                 tttttcccat aatatgggaa atattttaag tctatcattc cattatgagg ataaactgct    300 
               
               
                   
               
               
                 acatttggta tatcttcatt ctttgaaaca caatctatcc ttggcactcc ttcag         355 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 148 
               
               
                 &lt;211&gt; LENGTH: 369 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 148 
               
               
                   
               
               
                 aggtctctct ccccctctcc ctctcctgcc agccaagtga agacatgctt acttcccctt     60 
               
               
                   
               
               
                 caccttcctt catgatgtgg gaagagtgct gcaacccagc cctagccaac accgcatgag    120 
               
               
                   
               
               
                 agggagtgtg ccgagggctt ctgagaaggt ttctctcaca tctagaaaga agcgcttaag    180 
               
               
                   
               
               
                 atgtggcagc ccctcttctt caagtggctc ttgtcctgtt gccctgggag ttctcaaatt    240 
               
               
                   
               
               
                 gctgcagcag cctccatcca gcctgaggat gacatcaata cacagaggaa gaagagtcag    300 
               
               
                   
               
               
                 gaaaagatga gagaagttac agactctcct gggcgacccc gagagcttac cattcctcag    360 
               
               
                   
               
               
                 acttcttca                                                            369 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 149 
               
               
                 &lt;211&gt; LENGTH: 620 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (169) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (171) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (222) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (472) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (528) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (559) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: modified_base 
               
               
                 &lt;222&gt; LOCATION: (599) 
               
               
                 &lt;223&gt; OTHER INFORMATION: Where n is a, c, g or t 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 149 
               
               
                   
               
               
                 actagtcaaa aatgctaaaa taatttggga gaaaatattt tttaagtagt gttatagttt     60 
               
               
                   
               
               
                 catgtttatc ttttattatg ttttgtgaag ttgtgtcttt tcactaatta cctatactat    120 
               
               
                   
               
               
                 gccaatattt ccttatatct atccataaca tttatactac atttgtaana naatatgcac    180 
               
               
                   
               
               
                 gtgaaactta acactttata aggtaaaaat gaggtttcca anatttaata atctgatcaa    240 
               
               
                   
               
               
                 gttcttgtta tttccaaata gaatggactt ggtctgttaa gggctaagga gaagaggaag    300 
               
               
                   
               
               
                 ataaggttaa aagttgttaa tgaccaaaca ttctaaaaga aatgcaaaaa aaaagtttat    360 
               
               
                   
               
               
                 tttcaagcct tcgaactatt taaggaaagc aaaatcattt cctaaatgca tatcatttgt    420 
               
               
                   
               
               
                 gagaatttct cattaatatc ctgaatcatt catttcacta aggctcatgt tnactccgat    480 
               
               
                   
               
               
                 atgtctctaa gaaagtacta tttcatggtc caaacctggt tgccatantt gggtaaaggc    540 
               
               
                   
               
               
                 tttcccttaa gtgtgaaant atttaaaatg aaattttcct ctttttaaaa attctttana    600 
               
               
                   
               
               
                 agggttaagg gtgttgggga                                                620 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 150 
               
               
                 &lt;211&gt; LENGTH: 371 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 150 
               
               
                   
               
               
                 ggtccgatca aaacctgcta cctccccaag actttactag tgccgataaa ctttctcaaa     60 
               
               
                   
               
               
                 gagcaaccag tatcacttcc ctgtttataa aacctctaac catctctttg ttctttgaac    120 
               
               
                   
               
               
                 atgctgaaaa ccacctggtc tgcatgtatg cccgaatttg yaattctttt ctctcaaatg    180 
               
               
                   
               
               
                 aaaatttaat tttagggatt catttctata ttttcacata tgtagtatta ttatttcctt    240 
               
               
                   
               
               
                 atatgtgtaa ggtgaaattt atggtatttg agtgtgcaag aaaatatatt tttaaagctt    300 
               
               
                   
               
               
                 tcatttttcc cccagtgaat gatttagaat tttttatgta aatatacaga atgttttttc    360 
               
               
                   
               
               
                 ttacttttat a                                                         371 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 151 
               
               
                 &lt;211&gt; LENGTH: 4655 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 151 
               
               
                   
               
               
                 gggacttgag ttctgttatc ttcttaagta gattcatatt gtaagggtct cggggtgggg     60 
               
               
                   
               
               
                 gggttggcaa aatcctggag ccagaagaaa ggacagcagc attgatcaat cttacagcta    120 
               
               
                   
               
               
                 acatgttgta cctggaaaac aatgcccaga ctcaatttag tgagccacag tacacgaacc    180 
               
               
                   
               
               
                 tggggctcct gaacagcatg gaccagcaga ttcagaacgg ctcctcgtcc accagtccct    240 
               
               
                   
               
               
                 ataacacaga ccacgcgcag aacagcgtca cggcgccctc gccctacgca cagcccagct    300 
               
               
                   
               
               
                 ccaccttcga tgctctctct ccatcacccg ccatcccctc caacaccgac tacccaggcc    360 
               
               
                   
               
               
                 cgcacagttt cgacgtgtcc ttccagcagt cgagcaccgc caagtcggcc acctggacgt    420 
               
               
                   
               
               
                 attccactga actgaagaaa ctctactgcc aaattgcaaa gacatgcccc atccagatca    480 
               
               
                   
               
               
                 aggtgatgac cccacctcct cagggagctg ttatccgcgc catgcctgtc tacaaaaaag    540 
               
               
                   
               
               
                 ctgagcacgt cacggaggtg gtgaagcggt gccccaacca tgagctgagc cgtgaattca    600 
               
               
                   
               
               
                 acgagggaca gattgcccct yctagtcatt tgattcgagt agaggggaac agccatgccc    660 
               
               
                   
               
               
                 agtatgtaga agatcccatc acaggaagac agagtgtgct ggtaccttat gagccacccc    720 
               
               
                   
               
               
                 aggttggcac tgaattcacg acagtcttgt acaatttcat gtgtaacagc agttgtgttg    780 
               
               
                   
               
               
                 gagggatgaa ccgccgtcca attttaatca ttgttactct ggaaaccaga gatgggcaag    840 
               
               
                   
               
               
                 tcctgggccg acgctgcttt gaggcccgga tctgtgcttg cccaggaaga gacaggaagg    900 
               
               
                   
               
               
                 cggatgaaga tagcatcaga aagcagcaag tttcggacag tacaaagaac ggtgatggta    960 
               
               
                   
               
               
                 cgaagcgccc gtttcgtcag aacacacatg gtatccagat gacatccatc aagaaacgaa   1020 
               
               
                   
               
               
                 gatccccaga tgatgaactg gtatacttac cagtgagggg ccgtgagact tatgaaatgc   1080 
               
               
                   
               
               
                 tggtgaagat caaagagtcc ctggaactca tgcagtacct tcttcagcac acaattgaaa   1140 
               
               
                   
               
               
                 cgtacaggca acagcaacag cagcagcacc agcacttact tcagaaacag acctcaatac   1200 
               
               
                   
               
               
                 agtctccatc ttcatatggt aacagctccc cacctctgaa caaaatgaac agcatgaaca   1260 
               
               
                   
               
               
                 agctgccttc tgtgagccag cttatcaacc ctcagcagcg caacgccctc actcctacaa   1320 
               
               
                   
               
               
                 ccattcctga tggcatggga gccaacattc ccatgatggg cacccacatg ccaatggctg   1380 
               
               
                   
               
               
                 gagacatgaa tggactcagc cccacccagg cactccctcc cccactctcc atgccatcca   1440 
               
               
                   
               
               
                 cctcccactg cacaccccca cctccgtatc ccacagattg cagcattgtc agtttcttag   1500 
               
               
                   
               
               
                 cgaggttggg ctgttcatca tgtctggact atttcacgac ccaggggctg accaccatct   1560 
               
               
                   
               
               
                 atcagattga gcattactcc atggatgatc tggcaagtct gaaaatccct gagcaatttc   1620 
               
               
                   
               
               
                 gacatgcgat ctggaagggc atcctggacc accggcagct ccacgaattc tcctcccctt   1680 
               
               
                   
               
               
                 ctcatctcct gcggacccca agcagtgcct ctacagtcag tgtgggctcc agtgagaccc   1740 
               
               
                   
               
               
                 ggggtgagcg tgttattgat gctgtgcgat tcaccctccg ccagaccatc tctttcccac   1800 
               
               
                   
               
               
                 cccgagatga gtggaatgac ttcaactttg acatggatgc tcgccgcaat aagcaacagc   1860 
               
               
                   
               
               
                 gcatcaaaga ggagggggag tgagcctcac catgtgagct cttcctatcc ctctcctaac   1920 
               
               
                   
               
               
                 tgccagcccc ctaaaagcac tcctgcttaa tcttcaaagc cttctcccta gctcctcccc   1980 
               
               
                   
               
               
                 ttcctcttgt ctgatttctt aggggaagga gaagtaagag gcttacttct taccctaacc   2040 
               
               
                   
               
               
                 atctgacctg gcatctaatt ctgattctgg ctttaagcct tcaaaactat agcttgcaga   2100 
               
               
                   
               
               
                 actgtagctt gccatggcta ggtagaagtg agcaaaaaag agttgggtgt ctccttaagc   2160 
               
               
                   
               
               
                 tgcagagatt tctcattgac ttttataaag catgttcacc cttatagtct aagactatat   2220 
               
               
                   
               
               
                 atataaatgt ataaatatac agtatagatt tttgggtggg gggcattgag tattgtttaa   2280 
               
               
                   
               
               
                 aatgtaattt aaatgaaaga aaattgagtt gcacttattg accatttttt aatttacttg   2340 
               
               
                   
               
               
                 ttttggatgg cttgtctata ctccttccct taaggggtat catgtatggt gataggtatc   2400 
               
               
                   
               
               
                 tagagcttaa tgctacatgt gagtgacgat gatgtacaga ttctttcagt tctttggatt   2460 
               
               
                   
               
               
                 ctaaatacat gccacatcaa acctttgagt agatccattt ccattgctta ttatgtaggt   2520 
               
               
                   
               
               
                 aagactgtag atatgtattc ttttctcagt gttggtatat tttatattac tgacatttct   2580 
               
               
                   
               
               
                 tctagtgatg atggttcacg ttggggtgat ttaatccagt tataagaaga agttcatgtc   2640 
               
               
                   
               
               
                 caaacgtcct ctttagtttt tggttgggaa tgaggaaaat tcttaaaagg cccatagcag   2700 
               
               
                   
               
               
                 ccagttcaaa aacacccgac gtcatgtatt tgagcatatc agtaaccccc ttaaatttaa   2760 
               
               
                   
               
               
                 taccagatac cttatcttac aatattgatt gggaaaacat ttgctgccat tacagaggta   2820 
               
               
                   
               
               
                 ttaaaactaa atttcactac tagattgact aactcaaata cacatttgct actgttgtaa   2880 
               
               
                   
               
               
                 gaattctgat tgatttgatt gggatgaatg ccatctatct agttctaaca gtgaagtttt   2940 
               
               
                   
               
               
                 actgtctatt aatattcagg gtaaatagga atcattcaga aatgttgagt ctgtactaaa   3000 
               
               
                   
               
               
                 cagtaagata tctcaatgaa ccataaattc aactttgtaa aaatcttttg aagcatagat   3060 
               
               
                   
               
               
                 aatattgttt ggtaaatgtt tcttttgttt ggtaaatgtt tcytttaaag accctcctat   3120 
               
               
                   
               
               
                 tctataaaac tctgcatgta gaggcttgtt tacctttctc tctctaaggt ttacaatagg   3180 
               
               
                   
               
               
                 agtggtgatt tgaaaaatat aaaattatga gattggtttt cctgtggcat aaattgcatc   3240 
               
               
                   
               
               
                 actgtatcat tttctttttt aaccggtaag agtttcagtt tgttggaaag taactgtgag   3300 
               
               
                   
               
               
                 aacccagttt cccgtccatc tcccttaggg actacccata gacatgaaag gtccccacag   3360 
               
               
                   
               
               
                 agcaagagat aagtctttca tggctgctgt tgcttaaacc acttaaacga agagttccct   3420 
               
               
                   
               
               
                 tgaaactttg ggaaaacatg ttaatgacaa tattccagat ctttcagaaa tataacacat   3480 
               
               
                   
               
               
                 ttttttgcat gcatgcaaat gagctctgaa atcttcccat gcattctggt caagggctgt   3540 
               
               
                   
               
               
                 cattgcacat aagcttccat tttaatttta aagtgcaaaa gggccagcgt ggctctaaaa   3600 
               
               
                   
               
               
                 ggtaatgtgt ggattgcctc tgaaaagtgt gtatatattt tgtgtgaaat tgcatacttt   3660 
               
               
                   
               
               
                 gtattttgat tatttttttt ttcttcttgg gatagtggga tttccagaac cacacttgaa   3720 
               
               
                   
               
               
                 accttttttt atcgtttttg tattttcatg aaaataccat ttagtaagaa taccacatca   3780 
               
               
                   
               
               
                 aataagaaat aatgctacaa ttttaagagg ggagggaagg gaaagttttt ttttttatta   3840 
               
               
                   
               
               
                 tttttttaaa attttgtatg ttaaagagaa tgagtccttg atttcaaagt tttgttgtac   3900 
               
               
                   
               
               
                 ttaaatggta ataagcactg taaacttctg caacaagcat gcagctttgc aaacccatta   3960 
               
               
                   
               
               
                 aggggaagaa tgaaagctgt tccttggtcc tagtaagaag acaaactgct tcccttactt   4020 
               
               
                   
               
               
                 tgctgagggt ttgaataaac ctaggacttc cgagctatgt cagtactatt caggtaacac   4080 
               
               
                   
               
               
                 tagggccttg gaaatccctg tactgtgtct catggatttg gcactagcca aagcgaggca   4140 
               
               
                   
               
               
                 ccccttactg gcttacctcc tcatggcagc ctactctcct tgagtgtatg agtagccagg   4200 
               
               
                   
               
               
                 gtaaggggta aaaggatagt aagcatagaa accactagaa agtgggctta atggagttct   4260 
               
               
                   
               
               
                 tgtggcctca gctcaatgca gttagctgaa gaattgaaaa gtttttgttt ggagacgttt   4320 
               
               
                   
               
               
                 ataaacagaa atggaaagca gagttttcat taaatccttt tacctttttt ttttcttggt   4380 
               
               
                   
               
               
                 aatcccctaa aataacagta tgtgggatat tgaatgttaa agggatattt ttttctatta   4440 
               
               
                   
               
               
                 tttttataat tgtacaaaat taagcaaatg ttaaaagttt tatatgcttt attaatgttt   4500 
               
               
                   
               
               
                 tcaaaaggta ttatacatgt gatacatttt ttaagcttca gttgcttgtc ttctggtact   4560 
               
               
                   
               
               
                 ttctgttatg ggcttttggg gagccagaag ccaatctaca atctcttttt gtttgccagg   4620 
               
               
                   
               
               
                 acatgcaata aaatttaaaa aataaataaa aacta                              4655 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 152 
               
               
                 &lt;211&gt; LENGTH: 586 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 152 
               
               
                   
               
               
                 Met Leu Tyr Leu Glu Asn Asn Ala Gln Thr Gln Phe Ser Glu Pro Gln 
               
               
                  1               5                  10                  15 
               
               
                   
               
               
                 Tyr Thr Asn Leu Gly Leu Leu Asn Ser Met Asp Gln Gln Ile Gln Asn 
               
               
                             20                  25                  30 
               
               
                   
               
               
                 Gly Ser Ser Ser Thr Ser Pro Tyr Asn Thr Asp His Ala Gln Asn Ser 
               
               
                         35                  40                  45 
               
               
                   
               
               
                 Val Thr Ala Pro Ser Pro Tyr Ala Gln Pro Ser Ser Thr Phe Asp Ala 
               
               
                     50                  55                  60 
               
               
                   
               
               
                 Leu Ser Pro Ser Pro Ala Ile Pro Ser Asn Thr Asp Tyr Pro Gly Pro 
               
               
                 65                  70                  75                  80 
               
               
                   
               
               
                 His Ser Phe Asp Val Ser Phe Gln Gln Ser Ser Thr Ala Lys Ser Ala 
               
               
                                 85                  90                  95 
               
               
                   
               
               
                 Thr Trp Thr Tyr Ser Thr Glu Leu Lys Lys Leu Tyr Cys Gln Ile Ala 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Lys Thr Cys Pro Ile Gln Ile Lys Val Met Thr Pro Pro Pro Gln Gly 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Ala Val Ile Arg Ala Met Pro Val Tyr Lys Lys Ala Glu His Val Thr 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Glu Val Val Lys Arg Cys Pro Asn His Glu Leu Ser Arg Glu Phe Asn 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Glu Gly Gln Ile Ala Pro Ser Ser His Leu Ile Arg Val Glu Gly Asn 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Ser His Ala Gln Tyr Val Glu Asp Pro Ile Thr Gly Arg Gln Ser Val 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Leu Val Pro Tyr Glu Pro Pro Gln Val Gly Thr Glu Phe Thr Thr Val 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Leu Tyr Asn Phe Met Cys Asn Ser Ser Cys Val Gly Gly Met Asn Arg 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Arg Pro Ile Leu Ile Ile Val Thr Leu Glu Thr Arg Asp Gly Gln Val 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Leu Gly Arg Arg Cys Phe Glu Ala Arg Ile Cys Ala Cys Pro Gly Arg 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Asp Arg Lys Ala Asp Glu Asp Ser Ile Arg Lys Gln Gln Val Ser Asp 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Ser Thr Lys Asn Gly Asp Gly Thr Lys Arg Pro Phe Arg Gln Asn Thr 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 His Gly Ile Gln Met Thr Ser Ile Lys Lys Arg Arg Ser Pro Asp Asp 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Glu Leu Val Tyr Leu Pro Val Arg Gly Arg Glu Thr Tyr Glu Met Leu 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 Val Lys Ile Lys Glu Ser Leu Glu Leu Met Gln Tyr Leu Leu Gln His 
               
               
                                 325                 330                 335 
               
               
                   
               
               
                 Thr Ile Glu Thr Tyr Arg Gln Gln Gln Gln Gln Gln His Gln His Leu 
               
               
                             340                 345                 350 
               
               
                   
               
               
                 Leu Gln Lys Gln Thr Ser Ile Gln Ser Pro Ser Ser Tyr Gly Asn Ser 
               
               
                         355                 360                 365 
               
               
                   
               
               
                 Ser Pro Pro Leu Asn Lys Met Asn Ser Met Asn Lys Leu Pro Ser Val 
               
               
                     370                 375                 380 
               
               
                   
               
               
                 Ser Gln Leu Ile Asn Pro Gln Gln Arg Asn Ala Leu Thr Pro Thr Thr 
               
               
                 385                 390                 395                 400 
               
               
                   
               
               
                 Ile Pro Asp Gly Met Gly Ala Asn Ile Pro Met Met Gly Thr His Met 
               
               
                                 405                 410                 415 
               
               
                   
               
               
                 Pro Met Ala Gly Asp Met Asn Gly Leu Ser Pro Thr Gln Ala Leu Pro 
               
               
                             420                 425                 430 
               
               
                   
               
               
                 Pro Pro Leu Ser Met Pro Ser Thr Ser His Cys Thr Pro Pro Pro Pro 
               
               
                         435                 440                 445 
               
               
                   
               
               
                 Tyr Pro Thr Asp Cys Ser Ile Val Ser Phe Leu Ala Arg Leu Gly Cys 
               
               
                     450                 455                 460 
               
               
                   
               
               
                 Ser Ser Cys Leu Asp Tyr Phe Thr Thr Gln Gly Leu Thr Thr Ile Tyr 
               
               
                 465                 470                 475                 480 
               
               
                   
               
               
                 Gln Ile Glu His Tyr Ser Met Asp Asp Leu Ala Ser Leu Lys Ile Pro 
               
               
                                 485                 490                 495 
               
               
                   
               
               
                 Glu Gln Phe Arg His Ala Ile Trp Lys Gly Ile Leu Asp His Arg Gln 
               
               
                             500                 505                 510 
               
               
                   
               
               
                 Leu His Glu Phe Ser Ser Pro Ser His Leu Leu Arg Thr Pro Ser Ser 
               
               
                         515                 520                 525 
               
               
                   
               
               
                 Ala Ser Thr Val Ser Val Gly Ser Ser Glu Thr Arg Gly Glu Arg Val 
               
               
                     530                 535                 540 
               
               
                   
               
               
                 Ile Asp Ala Val Arg Phe Thr Leu Arg Gln Thr Ile Ser Phe Pro Pro 
               
               
                 545                 550                 555                 560 
               
               
                   
               
               
                 Arg Asp Glu Trp Asn Asp Phe Asn Phe Asp Met Asp Ala Arg Arg Asn 
               
               
                                 565                 570                 575 
               
               
                   
               
               
                 Lys Gln Gln Arg Ile Lys Glu Glu Gly Glu 
               
               
                             580                 585 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 153 
               
               
                 &lt;211&gt; LENGTH: 2007 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 153 
               
               
                   
               
               
                 gaattcgtcg ctgctccagg gaaagttctg ttactccact gactctctct tttcctgata     60 
               
               
                   
               
               
                 acatggccag caagaaagta attacagtgt ttggagcaac aggagctcaa ggtggctctg    120 
               
               
                   
               
               
                 tggccagggc aattttggag agcaaaaaat ttgcagtgag agcagtgacc agggatgtga    180 
               
               
                   
               
               
                 cttgaccaaa tgccctggag ctccagcgcc ttggagctga ggtggtcaaa ggtgacctga    240 
               
               
                   
               
               
                 atgataaagc atcggtggac agtgccttaa aaggtgtcta tggggccttc ttggtgacca    300 
               
               
                   
               
               
                 acttctggga ccctctcaac caagataagg aagtgtgtcg ggggaagctg gtggcagact    360 
               
               
                   
               
               
                 ccgccaagca cctgggtctg aagcacgtgg tgtacagcgg cctggagaac gtcaagcgac    420 
               
               
                   
               
               
                 tgacggatgg caagctggag gtgccgcact ttgacagcaa gggcgaggtg gaggagtact    480 
               
               
                   
               
               
                 tctggtccat tggcatcccc atgaccagtg tccgcgtggc ggcctacttt gaaaactttc    540 
               
               
                   
               
               
                 tcgcggcgtg gcggcccgtg aaagcctctg atggagatta ctacaccttg gctgtaccga    600 
               
               
                   
               
               
                 tgggagatgt accaatggat ggtatctctg ttgctgatat tggagcagcc gtctctagca    660 
               
               
                   
               
               
                 tttttaattc tccagaggaa tttttaggca aggccgtggg gctcagtgca gaagcactaa    720 
               
               
                   
               
               
                 caatacagca atatgctgat gttttgtcca aggctttggg gaaagaagtc cgagatgcaa    780 
               
               
                   
               
               
                 agattacccc ggaagctttc gagaagctgg gattccctgc agcaaaggaa atagccaata    840 
               
               
                   
               
               
                 tgtgtcgttt ctatgaaatg aagccagacc gagatgtcaa tctcacccac caactaaatc    900 
               
               
                   
               
               
                 ccaaagtcaa aagcttcagc cagtttatct cagagaacca gggagccttc aagggcatgt    960 
               
               
                   
               
               
                 agaaaatcag ctgttcagat aggcctctgc accacacagc ctctttcctc tctgatcctt   1020 
               
               
                   
               
               
                 ttcctcttta cggcacaaca ttcatgttga cagaacatgc tggaatgcaa ttgtttgcaa   1080 
               
               
                   
               
               
                 caccgaagga tttcctgcgg tcgcctcttc agtaggaagc actgcattgg tgataggaca   1140 
               
               
                   
               
               
                 cggtaatttg attcacattt aacttgctag ttagtgataa gggtggtaca actgtttggt   1200 
               
               
                   
               
               
                 aaaatgagaa gcctcggaac ttggagcttc tctcctacca ctaatgggag ggcagattat   1260 
               
               
                   
               
               
                 actgggattt ctcctgggtg agtaatttca agccctaatg ctgaaattcc cctaggcagc   1320 
               
               
                   
               
               
                 tccagttttc tcaactgcat tgcaaaattc ccagtgaact tttaagtact tttaacttaa   1380 
               
               
                   
               
               
                 aaaaatgaac atctttgtag agaattttct ggggaacatg gtgttcaatg aacaagcaca   1440 
               
               
                   
               
               
                 agcattggaa atgctaaaat tcagttttgc ctcaagattg gaagtttatt ttctgactca   1500 
               
               
                   
               
               
                 ttcatgaagt catctattga gccaccattc aattattcat ctattaattc cttgatcctt   1560 
               
               
                   
               
               
                 catttatcca ttctgcaaac ttttcttgag caccagcacg ggtggccatt tgtggacttc   1620 
               
               
                   
               
               
                 tcttcattcc tatgtgtttt cttatcaaag tgatccactc tcgaaaggct cctttccagt   1680 
               
               
                   
               
               
                 ctgtggttgg gttcaagtca tgccagggcc agggggccca tctcctcgtt tagctctagg   1740 
               
               
                   
               
               
                 caaaatccag gggatctgca gtggggagcg ggggcaggaa gctggaggga aggcctgtga   1800 
               
               
                   
               
               
                 agggtaggga tgtggaaaga caaggtgaca gaaggaccca ataggacctt tctatatctc   1860 
               
               
                   
               
               
                 tggcttagca ttttctacat catattgtaa tcgtcttatt tgctagtttt cttccttact   1920 
               
               
                   
               
               
                 gtgagtgact aacagtcatc tttatcccag tgcctggtac ataataagtg atcaataaat   1980 
               
               
                   
               
               
                 gttgattgac taaaaaaaaa aaaaaaa                                       2007 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 154 
               
               
                 &lt;211&gt; LENGTH: 2148 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 154 
               
               
                   
               
               
                 gaattcgtcg ctgctccagg gaaagttctg ttactccact gactctctct tttcctgata     60 
               
               
                   
               
               
                 acatggccag caagaaagta attacagtgt ttggagcaac aggagctcaa ggtggctctg    120 
               
               
                   
               
               
                 tggccagggc aattttggag agcaaaaaat ttgcagtgag agcagtgacc agggatgtga    180 
               
               
                   
               
               
                 cttgaccaaa tgccctggag ctccagcgcc ttggagctga ggtggtcaaa ggtgacctga    240 
               
               
                   
               
               
                 atgataaagc atcggtggac agtgccttaa aaggggaagc tggtggcaga ctccgccaag    300 
               
               
                   
               
               
                 cacctgggtc tgaagcacgt ggtgtacagc ggcctggaga acgtcaagcg actgacggat    360 
               
               
                   
               
               
                 ggcaagctgg aggtgccgca ctttgacagc aagggcgagg tggaggagta cttctggtcc    420 
               
               
                   
               
               
                 attggcatcc ccatgaccag tgtccgcgtg gcggcctact ttgaaaactt tctcgcggcg    480 
               
               
                   
               
               
                 tggcggcccg tgaaagcctc tgatggagat tactacacct tggctgtacc gatgggagat    540 
               
               
                   
               
               
                 gtaccaatgg atggtatctc tgttgctgat attggagcag ccgtctctag catttttaat    600 
               
               
                   
               
               
                 tctccagagg aatttttagg caaggccgtg gggctcagtg cagaagcact aacaatacag    660 
               
               
                   
               
               
                 caatatgctg atgttttgtc caaggctttg gggaaagaag tccgagatgc aaagactatc    720 
               
               
                   
               
               
                 tgtgctatag atgaccagaa aacagtggaa gaaggtttca tggaagacgt gggcttgagt    780 
               
               
                   
               
               
                 tggtccttga gggaacatga ccatgtatag acagaggagg catcaagaag gctggcctgg    840 
               
               
                   
               
               
                 ctaattctgg aataaacacg acaaaccaga ggcagtacgg gaaggaggca aattctggct    900 
               
               
                   
               
               
                 ctgcctctat ccttgattac cccggaagct ttcgagaagc tgggattccc tgcagcaaag    960 
               
               
                   
               
               
                 gaaatagcca atatgtgtcg tttctatgaa atgaagccag accgagatgt caatctcacc   1020 
               
               
                   
               
               
                 caccaactaa atcccaaagt caaaagcttc agccatttta tctcagagaa ccagggagcc   1080 
               
               
                   
               
               
                 ttcaagggca tgtagaaaat cagctgttca gataggcctc tgcaccacac agcctctttc   1140 
               
               
                   
               
               
                 ctctctgatc cttttcctct ttacggcaca acattcatgt tgacagaaca tgctggaatg   1200 
               
               
                   
               
               
                 caattgtttg caacaccgaa ggatttcctg cggtcgcctc ttcagtagga agcactgcat   1260 
               
               
                   
               
               
                 tggtgatagg acacggtaat ttgattcaca tttaacttgc tagttagtga taagggtggt   1320 
               
               
                   
               
               
                 acaactgttt ggtaaaatga gaagcctcgg aacttggagc ttctctccta ccactaatgg   1380 
               
               
                   
               
               
                 gagggcagat tatactggga tttctcctgg gtgagtaatt tcaagcccta atgctgaaat   1440 
               
               
                   
               
               
                 tcccctaggc agctccagtt ttctcaactg cattgcaaaa ttcccagtga acttttaagt   1500 
               
               
                   
               
               
                 acttttaact taaaaaaatg aacatctttg tagagaattt tctggggaac atggtgttca   1560 
               
               
                   
               
               
                 atgaacaagc acaagcattg gaaatgctaa aattcagttt tgcctcaaga ttggaagttt   1620 
               
               
                   
               
               
                 attttctgac tcattcatga agtcatctat tgagccacca ttcaattatt catctattaa   1680 
               
               
                   
               
               
                 ttccttgatc cttcatttat ccattctgca aacttttctt gagcaccagc acgggtggcc   1740 
               
               
                   
               
               
                 atttgtggac ttctcttcat tcctatgtgt tttcttatca aagtgatcca ctctcgaaag   1800 
               
               
                   
               
               
                 gctcctttcc agtctgtggt tgggttcaag tcatgccagg gccagggggc ccatctcctc   1860 
               
               
                   
               
               
                 gtttagctct aggcaaaatc caggggatct gcagtgggga gcgggggcag gaagctggag   1920 
               
               
                   
               
               
                 ggaaggcctg tgaagggtag ggatgtggaa agacaaggtg acagaaggac ccaataggac   1980 
               
               
                   
               
               
                 ctttctatat ctctggctta gcattttcta catcatattg taatcgtctt atttgctagt   2040 
               
               
                   
               
               
                 tttcttcctt actgtgagtg actaacagtc atctttatcc cagtgcctgg tacataataa   2100 
               
               
                   
               
               
                 gtgatcaata aatgttgatt gactaaatga aaaaaaaaaa aaaaaaaa                2148 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 155 
               
               
                 &lt;211&gt; LENGTH: 153 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 155 
               
               
                   
               
               
                 Met Thr Ser Val Arg Val Ala Ala Tyr Phe Glu Asn Phe Leu Ala Ala 
               
               
                  1               5                  10                  15 
               
               
                   
               
               
                 Trp Arg Pro Val Lys Ala Ser Asp Gly Asp Tyr Tyr Thr Leu Ala Val 
               
               
                             20                  25                  30 
               
               
                   
               
               
                 Pro Met Gly Asp Val Pro Met Asp Gly Ile Ser Val Ala Asp Ile Gly 
               
               
                         35                  40                  45 
               
               
                   
               
               
                 Ala Ala Val Ser Ser Ile Phe Asn Ser Pro Glu Glu Phe Leu Gly Lys 
               
               
                     50                  55                  60 
               
               
                   
               
               
                 Ala Val Gly Leu Ser Ala Glu Ala Leu Thr Ile Gln Gln Tyr Ala Asp 
               
               
                 65                  70                  75                  80 
               
               
                   
               
               
                 Val Leu Ser Lys Ala Leu Gly Lys Glu Val Arg Asp Ala Lys Ile Thr 
               
               
                                 85                  90                  95 
               
               
                   
               
               
                 Pro Glu Ala Phe Glu Lys Leu Gly Phe Pro Ala Ala Lys Glu Ile Ala 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Asn Met Cys Arg Phe Tyr Glu Met Lys Pro Asp Arg Asp Val Asn Leu 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Thr His Gln Leu Asn Pro Lys Val Lys Ser Phe Ser Gln Phe Ile Ser 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Glu Asn Gln Gly Ala Phe Lys Gly Met 
               
               
                 145                 150 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 156 
               
               
                 &lt;211&gt; LENGTH: 128 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 156 
               
               
                   
               
               
                 Met Thr Ser Val Arg Val Ala Ala Tyr Phe Glu Asn Phe Leu Ala Ala 
               
               
                  1               5                  10                  15 
               
               
                   
               
               
                 Trp Arg Pro Val Lys Ala Ser Asp Gly Asp Tyr Tyr Thr Leu Ala Val 
               
               
                             20                  25                  30 
               
               
                   
               
               
                 Pro Met Gly Asp Val Pro Met Asp Gly Ile Ser Val Ala Asp Ile Gly 
               
               
                         35                  40                  45 
               
               
                   
               
               
                 Ala Ala Val Ser Ser Ile Phe Asn Ser Pro Glu Glu Phe Leu Gly Lys 
               
               
                     50                  55                  60 
               
               
                   
               
               
                 Ala Val Gly Leu Ser Ala Glu Ala Leu Thr Ile Gln Gln Tyr Ala Asp 
               
               
                 65                  70                  75                  80 
               
               
                   
               
               
                 Val Leu Ser Lys Ala Leu Gly Lys Glu Val Arg Asp Ala Lys Thr Ile 
               
               
                                 85                  90                  95 
               
               
                   
               
               
                 Cys Ala Ile Asp Asp Gln Lys Thr Val Glu Glu Gly Phe Met Glu Asp 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Val Gly Leu Ser Trp Ser Leu Arg Glu His Asp His Val Ala Gly Ala 
               
               
                         115                 120                 125 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 157 
               
               
                 &lt;211&gt; LENGTH: 424 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                 &lt;220&gt; FEATURE: 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (320)...(320) 
               
               
                 &lt;221&gt; NAME/KEY: unsure 
               
               
                 &lt;222&gt; LOCATION: (322)...(322) 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 157 
               
               
                   
               
               
                 ctgcagcccg ggggatccac tagtccagtg tggtggaatt cattggtctt tacaagactt     60 
               
               
                   
               
               
                 ggatacatta cagcagacat ggaaatataa ttttaaaaaa tttctctcca acctccttca    120 
               
               
                   
               
               
                 aattcagtca ccactgttat attaccttct ccaggaaccc tccagtgggg aaggctgcga    180 
               
               
                   
               
               
                 tattagattt ccttgtatgc aaagtttttg ttgaaagctg tgctcagagg aggtgagagg    240 
               
               
                   
               
               
                 agaggaagga gaaaactgca tcataacttt acagaattga atctagagtc ttccccgaaa    300 
               
               
                   
               
               
                 agcccagaaa cttctctgcn gnatctggct tgtccatctg gtctaaggtg gctgcttctt    360 
               
               
                   
               
               
                 ccccagccat cgagtcagtt tgtgcccatg aataatacac gacctgctat ttcccatgac    420 
               
               
                   
               
               
                 tgct                                                                 424 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 158 
               
               
                 &lt;211&gt; LENGTH: 2099 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 158 
               
               
                   
               
               
                 ccgcggttaa aaggcgcagc aggtgggagc cggggccttc acccgaaacc cgacgagagc     60 
               
               
                   
               
               
                 ccgacagccg gcggcgcccg agcccgacct gcctgcccag ccggagcgaa gggcgccgcc    120 
               
               
                   
               
               
                 ccgcgcagag cccgcgccag ggccgccggc cgcagagcag ttaaaacgtg caggcaccag    180 
               
               
                   
               
               
                 aaggcacttc ctgtcggtga agaagacctg tctccggtgt cacgggcatc ctgtgttttg    240 
               
               
                   
               
               
                 caaacggggc tgacctccct tcctggggag caggaagggt cagggaagga aaagaagtac    300 
               
               
                   
               
               
                 agaagatctg gctaaacaat ttctgtatgg cgaaagaaaa attctaactt gtacgccctc    360 
               
               
                   
               
               
                 ttcatgcatc tttaattcaa tttgaatatt ccaggcgaca tcctcactga ccgagcaaag    420 
               
               
                   
               
               
                 attgacattc gtatcatcac tgtgcaccat tggcttctag gcactccagt ggggtaggag    480 
               
               
                   
               
               
                 aaggaggtct gaaaccctcg cagagggatc ttgccctcat tctttgggtc tgaaacactg    540 
               
               
                   
               
               
                 gcagtcgttg gaaacaggac tcagggataa accagcgcaa tggattgggg gacgctgcac    600 
               
               
                   
               
               
                 actttcatcg ggggtgtcaa caaacactcc accagcatcg ggaaggtgtg gatcacagtc    660 
               
               
                   
               
               
                 atctttattt tccgagtcat gatcctcgtg gtggctgccc aggaagtgtg gggtgacgag    720 
               
               
                   
               
               
                 caagaggact tcgtctgcaa cacactgcaa ccgggatgca aaaatgtgtg ctatgaccac    780 
               
               
                   
               
               
                 tttttcccgg tgtcccacat ccggctgtgg gccctccagc tgatcttcgt ctccacccca    840 
               
               
                   
               
               
                 gcgctgctgg tggccatgca tgtggcctac tacaggcacg aaaccactcg caagttcagg    900 
               
               
                   
               
               
                 cgaggagaga agaggaatga tttcaaagac atagaggaca ttaaaaagca gaaggttcgg    960 
               
               
                   
               
               
                 atagaggggt cgctgtggtg gacgtacacc agcagcatct ttttccgaat catctttgaa   1020 
               
               
                   
               
               
                 gcagccttta tgtatgtgtt ttacttcctt tacaatgggt accacctgcc ctgggtgttg   1080 
               
               
                   
               
               
                 aaatgtggga ttgacccctg ccccaacctt gttgactgct ttatttctag gccaacagag   1140 
               
               
                   
               
               
                 aagaccgtgt ttaccatttt tatgatttct gcgtctgtga tttgcatgct gcttaacgtg   1200 
               
               
                   
               
               
                 gcagagttgt gctacctgct gctgaaagtg tgttttagga gatcaaagag agcacagacg   1260 
               
               
                   
               
               
                 caaaaaaatc accccaatca tgccctaaag gagagtaagc agaatgaaat gaatgagctg   1320 
               
               
                   
               
               
                 atttcagata gtggtcaaaa tgcaatcaca ggttcccaag ctaaacattt caaggtaaaa   1380 
               
               
                   
               
               
                 tgtagctgcg tcataaggag acttctgtct tctccagaag gcaataccaa cctgaaagtt   1440 
               
               
                   
               
               
                 ccttctgtag cctgaagagt ttgtaaatga ctttcataat aaatagacac ttgagttaac   1500 
               
               
                   
               
               
                 tttttgtagg atacttgctc cattcataca caacgtaatc aaatatgtgg tccatctctg   1560 
               
               
                   
               
               
                 aaaacaagag actgcttgac aaaggagcat tgcagtcact ttgacaggtt ccttttaagt   1620 
               
               
                   
               
               
                 ggactctctg acaaagtggg tactttctga aaatttatat aactgttgtt gataaggaac   1680 
               
               
                   
               
               
                 atttatccag gaattgatac gtttattagg aaaagatatt tttataggct tggatgtttt   1740 
               
               
                   
               
               
                 tagttctgac tttgaattta tataaagtat ttttataatg actggtcttc cttacctgga   1800 
               
               
                   
               
               
                 aaaacatgcg atgttagttt tagaattaca ccacaagtat ctaaatttgg aacttacaaa   1860 
               
               
                   
               
               
                 gggtctatct tgtaaatatt gttttgcatt gtctgttggc aaatttgtga actgtcatga   1920 
               
               
                   
               
               
                 tacgcttaag gtggaaagtg ttcattgcac aatatatttt tactgctttc tgaatgtaga   1980 
               
               
                   
               
               
                 cggaacagtg tggaagcaga aggctttttt aactcatccg tttgccaatc attgcaaaca   2040 
               
               
                   
               
               
                 actgaaatgt ggatgtgatt gcctcaataa agctcgtccc cattgcttaa aaaaaaaaa    2099 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 159 
               
               
                 &lt;211&gt; LENGTH: 291 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 159 
               
               
                   
               
               
                 Met Asp Trp Gly Thr Leu His Thr Phe Ile Gly Gly Val Asn Lys His 
               
               
                  1               5                  10                  15 
               
               
                   
               
               
                 Ser Thr Ser Ile Gly Lys Val Trp Ile Thr Val Ile Phe Ile Phe Arg 
               
               
                             20                  25                  30 
               
               
                   
               
               
                 Val Met Ile Leu Val Val Ala Ala Gln Glu Val Trp Gly Asp Glu Gln 
               
               
                         35                  40                  45 
               
               
                   
               
               
                 Glu Asp Phe Val Cys Asn Thr Leu Gln Pro Gly Cys Lys Asn Val Cys 
               
               
                     50                  55                  60 
               
               
                   
               
               
                 Tyr Asp His Phe Phe Pro Val Ser His Ile Arg Leu Trp Ala Leu Gln 
               
               
                 65                  70                  75                  80 
               
               
                   
               
               
                 Leu Ile Phe Val Ser Thr Pro Ala Leu Leu Val Ala Met His Val Ala 
               
               
                                 85                  90                  95 
               
               
                   
               
               
                 Tyr Tyr Arg His Glu Thr Thr Arg Lys Phe Arg Arg Gly Glu Lys Arg 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Asn Asp Phe Lys Asp Ile Glu Asp Ile Lys Lys Gln Lys Val Arg Ile 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Glu Gly Ser Leu Trp Trp Thr Tyr Thr Ser Ser Ile Phe Phe Arg Ile 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Ile Phe Glu Ala Ala Phe Met Tyr Val Phe Tyr Phe Leu Tyr Asn Gly 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Tyr His Leu Pro Trp Val Leu Lys Cys Gly Ile Asp Pro Cys Pro Asn 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Leu Val Asp Cys Phe Ile Ser Arg Pro Thr Glu Lys Thr Val Phe Thr 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Ile Phe Met Ile Ser Ala Ser Val Ile Cys Met Leu Leu Asn Val Ala 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Glu Leu Cys Tyr Leu Leu Leu Lys Val Cys Phe Arg Arg Ser Lys Arg 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Ala Gln Thr Gln Lys Asn His Pro Asn His Ala Leu Lys Glu Ser Lys 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Gln Asn Glu Met Asn Glu Leu Ile Ser Asp Ser Gly Gln Asn Ala Ile 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Thr Gly Ser Gln Ala Lys His Phe Lys Val Lys Cys Ser Cys Val Ile 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Arg Arg Leu Leu Ser Ser Pro Glu Gly Asn Thr Asn Leu Lys Val Pro 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Ser Val Ala 
               
               
                     290 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 160 
               
               
                 &lt;211&gt; LENGTH: 3951 
               
               
                 &lt;212&gt; TYPE: DNA 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 160 
               
               
                   
               
               
                 tctgcatcca tattgaaaac ctgacacaat gtatgcagca ggctcagtgt gagtgaactg     60 
               
               
                   
               
               
                 gaggcttctc tacaacatga cccaaaggag cattgcaggt cctatttgca acctgaagtt    120 
               
               
                   
               
               
                 tgtgactctc ctggttgcct taagttcaga actcccattc ctgggagctg gagtacagct    180 
               
               
                   
               
               
                 tcaagacaat gggtataatg gattgctcat tgcaattaat cctcaggtac ctgagaatca    240 
               
               
                   
               
               
                 gaacctcatc tcaaacatta aggaaatgat aactgaagct tcattttacc tatttaatgc    300 
               
               
                   
               
               
                 taccaagaga agagtatttt tcagaaatat aaagatttta atacctgcca catggaaagc    360 
               
               
                   
               
               
                 taataataac agcaaaataa aacaagaatc atatgaaaag gcaaatgtca tagtgactga    420 
               
               
                   
               
               
                 ctggtatggg gcacatggag atgatccata caccctacaa tacagagggt gtggaaaaga    480 
               
               
                   
               
               
                 gggaaaatac attcatttca cacctaattt cctactgaat gataacttaa cagctggcta    540 
               
               
                   
               
               
                 cggatcacga ggccgagtgt ttgtccatga atgggcccac ctccgttggg gtgtgttcga    600 
               
               
                   
               
               
                 tgagtataac aatgacaaac ctttctacat aaatgggcaa aatcaaatta aagtgacaag    660 
               
               
                   
               
               
                 gtgttcatct gacatcacag gcatttttgt gtgtgaaaaa ggtccttgcc cccaagaaaa    720 
               
               
                   
               
               
                 ctgtattatt agtaagcttt ttaaagaagg atgcaccttt atctacaata gcacccaaaa    780 
               
               
                   
               
               
                 tgcaactgca tcaataatgt tcatgcaaag tttatcttct gtggttgaat tttgtaatgc    840 
               
               
                   
               
               
                 aagtacccac aaccaagaag caccaaacct acagaaccag atgtgcagcc tcagaagtgc    900 
               
               
                   
               
               
                 atgggatgta atcacagact ctgctgactt tcaccacagc tttcccatga acgggactga    960 
               
               
                   
               
               
                 gcttccacct cctcccacat tctcgcttgt agaggctggt gacaaagtgg tctgtttagt   1020 
               
               
                   
               
               
                 gctggatgtg tccagcaaga tggcagaggc tgacagactc cttcaactac aacaagccgc   1080 
               
               
                   
               
               
                 agaattttat ttgatgcaga ttgttgaaat tcataccttc gtgggcattg ccagtttcga   1140 
               
               
                   
               
               
                 cagcaaagga gagatcagag cccagctaca ccaaattaac agcaatgatg atcgaaagtt   1200 
               
               
                   
               
               
                 gctggtttca tatctgccca ccactgtatc agctaaaaca gacatcagca tttgttcagg   1260 
               
               
                   
               
               
                 gcttaagaaa ggatttgagg tggttgaaaa actgaatgga aaagcttatg gctctgtgat   1320 
               
               
                   
               
               
                 gatattagtg accagcggag atgataagct tcttggcaat tgcttaccca ctgtgctcag   1380 
               
               
                   
               
               
                 cagtggttca acaattcact ccattgccct gggttcatct gcagccccaa atctggagga   1440 
               
               
                   
               
               
                 attatcacgt cttacaggag gtttaaagtt ctttgttcca gatatatcaa actccaatag   1500 
               
               
                   
               
               
                 catgattgat gctttcagta gaatttcctc tggaactgga gacattttcc agcaacatat   1560 
               
               
                   
               
               
                 tcagcttgaa agtacaggtg aaaatgtcaa acctcaccat caattgaaaa acacagtgac   1620 
               
               
                   
               
               
                 tgtggataat actgtgggca acgacactat gtttctagtt acgtggcagg ccagtggtcc   1680 
               
               
                   
               
               
                 tcctgagatt atattatttg atcctgatgg acgaaaatac tacacaaata attttatcac   1740 
               
               
                   
               
               
                 caatctaact tttcggacag ctagtctttg gattccagga acagctaagc ctgggcactg   1800 
               
               
                   
               
               
                 gacttacacc ctgaacaata cccatcattc tctgcaagcc ctgaaagtga cagtgacctc   1860 
               
               
                   
               
               
                 tcgcgcctcc aactcagctg tgcccccagc cactgtggaa gcctttgtgg aaagagacag   1920 
               
               
                   
               
               
                 cctccatttt cctcatcctg tgatgattta tgccaatgtg aaacagggat tttatcccat   1980 
               
               
                   
               
               
                 tcttaatgcc actgtcactg ccacagttga gccagagact ggagatcctg ttacgctgag   2040 
               
               
                   
               
               
                 actccttgat gatggagcag gtgctgatgt tataaaaaat gatggaattt actcgaggta   2100 
               
               
                   
               
               
                 ttttttctcc tttgctgcaa atggtagata tagcttgaaa gtgcatgtca atcactctcc   2160 
               
               
                   
               
               
                 cagcataagc accccagccc actctattcc agggagtcat gctatgtatg taccaggtta   2220 
               
               
                   
               
               
                 cacagcaaac ggtaatattc agatgaatgc tccaaggaaa tcagtaggca gaaatgagga   2280 
               
               
                   
               
               
                 ggagcgaaag tggggcttta gccgagtcag ctcaggaggc tccttttcag tgctgggagt   2340 
               
               
                   
               
               
                 tccagctggc ccccaccctg atgtgtttcc accatgcaaa attattgacc tggaagctgt   2400 
               
               
                   
               
               
                 aaaagtagaa gaggaattga ccctatcttg gacagcacct ggagaagact ttgatcaggg   2460 
               
               
                   
               
               
                 ccaggctaca agctatgaaa taagaatgag taaaagtcta cagaatatcc aagatgactt   2520 
               
               
                   
               
               
                 taacaatgct attttagtaa atacatcaaa gcgaaatcct cagcaagctg gcatcaggga   2580 
               
               
                   
               
               
                 gatatttacg ttctcacccc aaatttccac gaatggacct gaacatcagc caaatggaga   2640 
               
               
                   
               
               
                 aacacatgaa agccacagaa tttatgttgc aatacgagca atggatagga actccttaca   2700 
               
               
                   
               
               
                 gtctgctgta tctaacattg cccaggcgcc tctgtttatt ccccccaatt ctgatcctgt   2760 
               
               
                   
               
               
                 acctgccaga gattatctta tattgaaagg agttttaaca gcaatgggtt tgataggaat   2820 
               
               
                   
               
               
                 catttgcctt attatagttg tgacacatca tactttaagc aggaaaaaga gagcagacaa   2880 
               
               
                   
               
               
                 gaaagagaat ggaacaaaat tattataaat aaatatccaa agtgtcttcc ttcttagata   2940 
               
               
                   
               
               
                 taagacccat ggccttcgac tacaaaaaca tactaacaaa gtcaaattaa catcaaaact   3000 
               
               
                   
               
               
                 gtattaaaat gcattgagtt tttgtacaat acagataaga tttttacatg gtagatcaac   3060 
               
               
                   
               
               
                 aaattctttt tgggggtaga ttagaaaacc cttacacttt ggctatgaac aaataataaa   3120 
               
               
                   
               
               
                 aattattctt taaagtaatg tctttaaagg caaagggaag ggtaaagtcg gaccagtgtc   3180 
               
               
                   
               
               
                 aaggaaagtt tgttttattg aggtggaaaa atagccccaa gcagagaaaa ggagggtagg   3240 
               
               
                   
               
               
                 tctgcattat aactgtctgt gtgaagcaat catttagtta ctttgattaa tttttctttt   3300 
               
               
                   
               
               
                 ctccttatct gtgcagaaca ggttgcttgt ttacaactga agatcatgct atatttcata   3360 
               
               
                   
               
               
                 tatgaagccc ctaatgcaaa gctctttacc tcttgctatt ttgttatata tattacagat   3420 
               
               
                   
               
               
                 gaaatctcac tgctaatgct cagagatctt ttttcactgt aagaggtaac ctttaacaat   3480 
               
               
                   
               
               
                 atgggtatta cctttgtctc ttcataccgg ttttatgaca aaggtctatt gaatttattt   3540 
               
               
                   
               
               
                 gtttgtaagt ttctactccc atcaaagcag ctttttaagt tattgccttg gttattatgg   3600 
               
               
                   
               
               
                 atgatagtta tagcccttat aatgccttaa ctaaggaaga aaagatgtta ttctgagttt   3660 
               
               
                   
               
               
                 gttttaatac atatatgaac atatagtttt attcaattaa accaaagaag aggtcagcag   3720 
               
               
                   
               
               
                 ggagatacta acctttggaa atgattagct ggctctgttt tttggttaaa taagagtctt   3780 
               
               
                   
               
               
                 taatcctttc tccatcaaga gttacttacc aagggcaggg gaagggggat atagaggtcc   3840 
               
               
                   
               
               
                 caaggaaata aaaatcatct ttcatcttta attttactcc ttcctcttat ttttttaaaa   3900 
               
               
                   
               
               
                 gattatcgaa caataaaatc atttgccttt ttaattaaaa acataaaaaa a            3951 
               
               
                   
               
               
                   
               
               
                 &lt;210&gt; SEQ ID NO 161 
               
               
                 &lt;211&gt; LENGTH: 943 
               
               
                 &lt;212&gt; TYPE: PRT 
               
               
                 &lt;213&gt; ORGANISM: Human 
               
               
                   
               
               
                 &lt;400&gt; SEQUENCE: 161 
               
               
                   
               
               
                 Met Thr Gln Arg Ser Ile Ala Gly Pro Ile Cys Asn Leu Lys Phe Val 
               
               
                  1               5                  10                  15 
               
               
                   
               
               
                 Thr Leu Leu Val Ala Leu Ser Ser Glu Leu Pro Phe Leu Gly Ala Gly 
               
               
                             20                  25                  30 
               
               
                   
               
               
                 Val Gln Leu Gln Asp Asn Gly Tyr Asn Gly Leu Leu Ile Ala Ile Asn 
               
               
                         35                  40                  45 
               
               
                   
               
               
                 Pro Gln Val Pro Glu Asn Gln Asn Leu Ile Ser Asn Ile Lys Glu Met 
               
               
                     50                  55                  60 
               
               
                   
               
               
                 Ile Thr Glu Ala Ser Phe Tyr Leu Phe Asn Ala Thr Lys Arg Arg Val 
               
               
                 65                  70                  75                  80 
               
               
                   
               
               
                 Phe Phe Arg Asn Ile Lys Ile Leu Ile Pro Ala Thr Trp Lys Ala Asn 
               
               
                                 85                  90                  95 
               
               
                   
               
               
                 Asn Asn Ser Lys Ile Lys Gln Glu Ser Tyr Glu Lys Ala Asn Val Ile 
               
               
                             100                 105                 110 
               
               
                   
               
               
                 Val Thr Asp Trp Tyr Gly Ala His Gly Asp Asp Pro Tyr Thr Leu Gln 
               
               
                         115                 120                 125 
               
               
                   
               
               
                 Tyr Arg Gly Cys Gly Lys Glu Gly Lys Tyr Ile His Phe Thr Pro Asn 
               
               
                     130                 135                 140 
               
               
                   
               
               
                 Phe Leu Leu Asn Asp Asn Leu Thr Ala Gly Tyr Gly Ser Arg Gly Arg 
               
               
                 145                 150                 155                 160 
               
               
                   
               
               
                 Val Phe Val His Glu Trp Ala His Leu Arg Trp Gly Val Phe Asp Glu 
               
               
                                 165                 170                 175 
               
               
                   
               
               
                 Tyr Asn Asn Asp Lys Pro Phe Tyr Ile Asn Gly Gln Asn Gln Ile Lys 
               
               
                             180                 185                 190 
               
               
                   
               
               
                 Val Thr Arg Cys Ser Ser Asp Ile Thr Gly Ile Phe Val Cys Glu Lys 
               
               
                         195                 200                 205 
               
               
                   
               
               
                 Gly Pro Cys Pro Gln Glu Asn Cys Ile Ile Ser Lys Leu Phe Lys Glu 
               
               
                     210                 215                 220 
               
               
                   
               
               
                 Gly Cys Thr Phe Ile Tyr Asn Ser Thr Gln Asn Ala Thr Ala Ser Ile 
               
               
                 225                 230                 235                 240 
               
               
                   
               
               
                 Met Phe Met Gln Ser Leu Ser Ser Val Val Glu Phe Cys Asn Ala Ser 
               
               
                                 245                 250                 255 
               
               
                   
               
               
                 Thr His Asn Gln Glu Ala Pro Asn Leu Gln Asn Gln Met Cys Ser Leu 
               
               
                             260                 265                 270 
               
               
                   
               
               
                 Arg Ser Ala Trp Asp Val Ile Thr Asp Ser Ala Asp Phe His His Ser 
               
               
                         275                 280                 285 
               
               
                   
               
               
                 Phe Pro Met Asn Gly Thr Glu Leu Pro Pro Pro Pro Thr Phe Ser Leu 
               
               
                     290                 295                 300 
               
               
                   
               
               
                 Val Glu Ala Gly Asp Lys Val Val Cys Leu Val Leu Asp Val Ser Ser 
               
               
                 305                 310                 315                 320 
               
               
                   
               
               
                 Lys Met Ala Glu Ala Asp Arg Leu Leu Gln Leu Gln Gln Ala Ala Glu 
               
               
                                 325                 330                 335 
               
               
                   
               
               
                 Phe Tyr Leu Met Gln Ile Val Glu Ile His Thr Phe Val Gly Ile Ala 
               
               
                             340                 345                 350 
               
               
                   
               
               
                 Ser Phe Asp Ser Lys Gly Glu Ile Arg Ala Gln Leu His Gln Ile Asn 
               
               
                         355                 360                 365 
               
               
                   
               
               
                 Ser Asn Asp Asp Arg Lys Leu Leu Val Ser Tyr Leu Pro Thr Thr Val 
               
               
                     370                 375                 380 
               
               
                   
               
               
                 Ser Ala Lys Thr Asp Ile Ser Ile Cys Ser Gly Leu Lys Lys Gly Phe 
               
               
                 385                 390                 395                 400 
               
               
                   
               
               
                 Glu Val Val Glu Lys Leu Asn Gly Lys Ala Tyr Gly Ser Val Met Ile 
               
               
                                 405                 410                 415 
               
               
                   
               
               
                 Leu Val Thr Ser Gly Asp Asp Lys Leu Leu Gly Asn Cys Leu Pro Thr 
               
               
                             420                 425                 430 
               
               
                   
               
               
                 Val Leu Ser Ser Gly Ser Thr Ile His Ser Ile Ala Leu Gly Ser Ser 
               
               
                         435                 440                 445 
               
               
                   
               
               
                 Ala Ala Pro Asn Leu Glu Glu Leu Ser Arg Leu Thr Gly Gly Leu Lys 
               
               
                     450                 455                 460 
               
               
                   
               
               
                 Phe Phe Val Pro Asp Ile Ser Asn Ser Asn Ser Met Ile Asp Ala Phe 
               
               
                 465                 470                 475                 480 
               
               
                   
               
               
                 Ser Arg Ile Ser Ser Gly Thr Gly Asp Ile Phe Gln Gln His Ile Gln 
               
               
                                 485                 490                 495 
               
               
                   
               
               
                 Leu Glu Ser Thr Gly Glu Asn Val Lys Pro His His Gln Leu Lys Asn 
               
               
                             500                 505                 510 
               
               
                   
               
               
                 Thr Val Thr Val Asp Asn Thr Val Gly Asn Asp Thr Met Phe Leu Val 
               
               
                         515                 520                 525 
               
               
                   
               
               
                 Thr Trp Gln Ala Ser Gly Pro Pro Glu Ile Ile Leu Phe Asp Pro Asp 
               
               
                     530                 535                 540 
               
               
                   
               
               
                 Gly Arg Lys Tyr Tyr Thr Asn Asn Phe Ile Thr Asn Leu Thr Phe Arg 
               
               
                 545                 550                 555                 560 
               
               
                   
               
               
                 Thr Ala Ser Leu Trp Ile Pro Gly Thr Ala Lys Pro Gly His Trp Thr 
               
               
                                 565                 570                 575 
               
               
                   
               
               
                 Tyr Thr Leu Asn Asn Thr His His Ser Leu Gln Ala Leu Lys Val Thr 
               
               
                             580                 585                 590 
               
               
                   
               
               
                 Val Thr Ser Arg Ala Ser Asn Ser Ala Val Pro Pro Ala Thr Val Glu 
               
               
                         595                 600                 605 
               
               
                   
               
               
                 Ala Phe Val Glu Arg Asp Ser Leu His Phe Pro His Pro Val Met Ile 
               
               
                     610                 615                 620 
               
               
                   
               
               
                 Tyr Ala Asn Val Lys Gln Gly Phe Tyr Pro Ile Leu Asn Ala Thr Val 
               
               
                 625                 630                 635                 640 
               
               
                   
               
               
                 Thr Ala Thr Val Glu Pro Glu Thr Gly Asp Pro Val Thr Leu Arg Leu 
               
               
                                 645                 650                 655 
               
               
                   
               
               
                 Leu Asp Asp Gly Ala Gly Ala Asp Val Ile Lys Asn Asp Gly Ile Tyr 
               
               
                             660                 665                 670 
               
               
                   
               
               
                 Ser Arg Tyr Phe Phe Ser Phe Ala Ala Asn Gly Arg Tyr Ser Leu Lys 
               
               
                         675                 680                 685 
               
               
                   
               
               
                 Val His Val Asn His Ser Pro Ser Ile Ser Thr Pro Ala His Ser Ile 
               
               
                     690                 695                 700 
               
               
                   
               
               
                 Pro Gly Ser His Ala Met Tyr Val Pro Gly Tyr Thr Ala Asn Gly Asn 
               
               
                 705                 710                 715                 720 
               
               
                   
               
               
                 Ile Gln Met Asn Ala Pro Arg Lys Ser Val Gly Arg Asn Glu Glu Glu 
               
               
                                 725                 730                 735 
               
               
                   
               
               
                 Arg Lys Trp Gly Phe Ser Arg Val Ser Ser Gly Gly Ser Phe Ser Val 
               
               
                             740                 745                 750 
               
               
                   
               
               
                 Leu Gly Val Pro Ala Gly Pro His Pro Asp Val Phe Pro Pro Cys Lys 
               
               
                         755                 760                 765 
               
               
                   
               
               
                 Ile Ile Asp Leu Glu Ala Val Lys Val Glu Glu Glu Leu Thr Leu Ser 
               
               
                     770                 775                 780 
               
               
                   
               
               
                 Trp Thr Ala Pro Gly Glu Asp Phe Asp Gln Gly Gln Ala Thr Ser Tyr 
               
               
                 785                 790                 795                 800 
               
               
                   
               
               
                 Glu Ile Arg Met Ser Lys Ser Leu Gln Asn Ile Gln Asp Asp Phe Asn 
               
               
                                 805                 810                 815 
               
               
                   
               
               
                 Asn Ala Ile Leu Val Asn Thr Ser Lys Arg Asn Pro Gln Gln Ala Gly 
               
               
                             820                 825                 830 
               
               
                   
               
               
                 Ile Arg Glu Ile Phe Thr Phe Ser Pro Gln Ile Ser Thr Asn Gly Pro 
               
               
                         835                 840                 845 
               
               
                   
               
               
                 Glu His Gln Pro Asn Gly Glu Thr His Glu Ser His Arg Ile Tyr Val 
               
               
                     850                 855                 860 
               
               
                   
               
               
                 Ala Ile Arg Ala Met Asp Arg Asn Ser Leu Gln Ser Ala Val Ser Asn 
               
               
                 865                 870                 875                 880 
               
               
                   
               
               
                 Ile Ala Gln Ala Pro Leu Phe Ile Pro Pro Asn Ser Asp Pro Val Pro 
               
               
                                 885                 890                 895 
               
               
                   
               
               
                 Ala Arg Asp Tyr Leu Ile Leu Lys Gly Val Leu Thr Ala Met Gly Leu 
               
               
                             900                 905                 910 
               
               
                   
               
               
                 Ile Gly Ile Ile Cys Leu Ile Ile Val Val Thr His His Thr Leu Ser 
               
               
                         915                 920                 925 
               
               
                   
               
               
                 Arg Lys Lys Arg Ala Asp Lys Lys Glu Asn Gly Thr Lys Leu Leu 
               
               
                     930                 935                 940