Patent Publication Number: US-11046659-B2

Title: 1,2,3-triazole derivative and insecticide and acaricide containing said derivative as active ingredient

Description:
TECHNICAL FIELD 
     The present invention relates to a novel 1,2,3-triazole derivative and an insecticide or acaricide containing the derivative as an active ingredient. 
     BACKGROUND ART 
     Heretofore, in the agricultural/horticultural field, insecticides or acaricides intended to control various pests are used in practice. However, conventional general-purpose insecticides or acaricides are not always satisfied in terms of efficacy, spectrum, residual effectiveness, etc. As well, the societal requirements such as reduction in the number of applications or the rate of application are not sufficiently fulfilled. 
     In addition, appearance of pests having gained resistance to conventional general-purpose insecticides or acaricides also becomes a problem. For example, in the cultivation of vegetables, fruit trees, ornamental flowers, teas, wheat/barley, etc., it is becoming difficult to control pests having gained resistance to insecticides or acaricides of various systems, for example, organophosphorus agents (e.g., fenitrothion, malathion, prothiofos, DDVP) and pyrethroid-based (e.g., permethrin, cypermerin, fenvalerate, cyhalothrin), benzoylurea-based (e.g., diflubenzuron, teflubenzuron, chlorfluazuron) and nereistoxin-based (e.g., cartap, bensultap) insecticides or acaricides. 
     Furthermore, although there are insecticides or acaricides to which pests have not yet gained resistance (for example, organic halogen-based agrochemicals such as DDT and BHC, and chlorinated cyclic diene-based agrochemicals such as aldrin, dieldrin, endrin, heptachlor and benzoepin), these are disadvantageous in view of toxicity, environmental pollution, etc. Accordingly, it is keenly demanded to develop a novel insecticide or acaricide exhibiting a sufficient control effect with a small dosage also on various pests having gained resistance to agricultural/horticultural insecticides or acaricides that have been conventionally used for general purposes. 
     As to a 1,2,3-triazole derivative exhibiting an insecticidal or acaricidal activity, for example, Patent Document 1 describes a 1,2,3-triazole derivative having an insecticidal or acaricidal activity against various pests but discloses none of the 1,2,3-triazole derivative according to the present invention. In addition, although a compound analogous to the present invention is described in Patent Documents 2 to 18, there is absolutely no description of the 1,2,3-triazole derivative of the present invention in which the 1,2,3-triazole ring is substituted at the 1-position with a 2-alkyl thio group, a 2-alkylsulfinyl group or a 2-alkylsulfonyl group and substituted with a phenyl group that may be substituted with other substituent. 
     BACKGROUND ART LITERATURE 
     Patent Document 
     Patent Document 1: WO 2011/113756 
     Patent Document 2: WO 2015/144895 
     Patent Document 3: WO 2015/144826 
     Patent Document 4: WO 2015/068719 
     Patent Document 5: JP-A-2015-003906 
     Patent Document 6: WO 2015/002211 
     Patent Document 7: WO 2015/000715 
     Patent Document 8: WO 2014/157600 
     Patent Document 9: WO 2014/148451 
     Patent Document 10: WO 2014/142292 
     Patent Document 11: WO 2014/132972 
     Patent Document 12: WO 2014/132971 
     Patent Document 13: WO 2014/123206 
     Patent Document 14: WO 2014/123205 
     Patent Document 15: WO 2014/104407 
     Patent Document 16: WO 2014/021468 
     Patent Document 17: WO 2014/002754 
     Patent Document 18: WO 2013/191188 
     SUMMARY OF THE INVENTION 
     Problems that the Invention is to Solve 
     An object of the present invention is to provide a novel 1,2,3-triazole derivative and an insecticide or acaricide containing the same. 
     Means for Solving the Problems 
     As a result of many intensive studies to attain the object above, the present inventors have found that a 1,2,3-triazole derivative represented by the following formula (1) has an insecticidal or acaricidal activity, and accomplished the present invention. 
     Accordingly, a first aspect of the present application relates to a 1,2,3-triazole derivative represented by the following formula (1) (in the present description, sometimes referred to as “compound of the present invention), and a second aspect relates to an insecticide or acaricide characterized by containing a 1,2,3-triazole derivative represented by formula (1) as an active ingredient. 
     More specifically, the present inventors have found that the above-described problems can be solved by the following configurations.
     &lt;1&gt; A 1,2,3-triazole derivative represented by the following formula (1):   

     
       
         
         
             
             
         
       
     
     wherein in the formula (1): 
     R represents a C1-C6 alkyl group or a C1-C6 haloalkyl group; 
     n represents an integer of 0 to 2; 
     each of W 1  and W 2  independently represents CH or a nitrogen atom; 
     X represents a hydrogen atom, a halogen atom, a cyano group, a nitro group, an amino group, a hydroxyl group, a carboxyl group, a C1-C6 alkyl group that may be substituted with a hydroxyl group or a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a (C1-C6 alkoxy)C1-C6 fluoroalkyl group, a C1-C6 alkoxy group, a C1-C6 alkylsulfonyloxy group, a (C1-C6 alkoxy)C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkoxy group, a C1-C6 alkylcarbonyl group, a C1-C6 haloalkylsulfonyloxy group, a C1-C6 alkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 haloalkylthio group, a C1-C6 haloalkylsulfinyl group, a C1-C6 haloalkylsulfonyl group, a C1-C6 alkylamino group, a (C1-C6 alkoxy)carbonyl group, a di(C1-C6 alkyl)amino group, a (C1-C6 alkyl)carbonylamino group, a (C1-C6 alkyl)carbonyl(C1-C6 alkyl)amino group, an N—(C1-C6 alkyl)carbamoyl group, an N,N′-di(C1-C6 alkyl)carbamoyl group, a pentafluorosulfanyl group, a triazolyl group that may be substituted with a C1-C6 alkyl group, an oxadiazolyl group that may be substituted with a C1-C6 alkyl group, a tetrazolyl group that may be substituted with a C1-C6 alkyl group, a (tetrazolyl that may be substituted with a C1-C6 haloalkyl group)C1-C6 alkyl group, a benzoyl group that may be substituted with a halogen atom, an arylsulfonyl group that may be substituted with a halogen atom, an arylsulfinyl group that may be substituted with a halogen atom, an arylthio group that may be substituted with a halogen atom, an arylamino group that may be substituted with a halogen atom, an aryloxy group that may be substituted with a halogen atom, or an aryl group that may be substituted with a halogen atom; 
     m represents an integer of 1 to 4 and when m represents an integer of 2 or more, respective X may be the same or different; 
     Q represents a phenyl group, a pyridyl group, a thiazolyl group, a quinolyl group, a benzoxazolyl group, a benzothiazolyl group or a benzimidazolyl group, each of which may be substituted with one or more groups selected from the group consisting of a halogen atom, a cyano group, a nitro group, a carboxyl group, a C1-C6 alkyl group that may be substituted with a hydroxyl group or a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkyl group {substituted with an N-carbamoyl group (that may be substituted with a C1-C6 alkyl group)}, a C1-C6 haloalkyl group {substituted with an N-arylcarbamoyl group (that may be substituted with a halogen atom or a C1-C6 alkyl group)}, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkoxycarbonyl group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, a C1-C6 haloalkylcarbonyl group, a pentafluorosulfanyl group, an N—(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 haloalkyl)carbamoyl group, an N-(phenyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N-(pyridyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N,N′-di(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 alkylcarbonyl)amino group, an N—(C1-C6 haloalkylcarbonyl)amino group, an N—(C1-C6 alkoxycarbonyl)amino group, an N—(C1-C6 haloalkoxycarbonyl)amino group, a C1-C6 alkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a C1-C6 haloalkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group and the phenyl group may be substituted with a halogen atom or a C1-C6 alkyl group, a (C1-C6 alkyl)aminosulfonyl group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, a phenoxy group that may be substituted with a halogen atom or a C1-C6 alkyl group, and a benzoyl group that may be substituted with a halogen atom; and 
     Z represents a hydrogen atom, a halogen atom, a cyano group, an amino group, a carboxyl group, a carbamoyl group, a C1-C6 alkyl group, a C3-C6 cycloalkyl group, a C1-C6 alkoxy group, a (C1-C6 alkoxy)C1-C6 alkyl group, a C1-C6 haloalkyl group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkylamino group, a di(C1-C6 alkyl)amino group, a C1-C6 alkoxycarbonyl group, a (C1-C6 alkyl)carbonylamino group, an N—(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 haloalkyl)carbamoyl group, an N-(phenyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N,N′-di(C1-C6 alkyl)carbamoyl group, a (C1-C6 haloalkyl)carbonylamino group, an N,N′-di(C1-C6 alkyl)carbonylamino group, an arylcarbonylamino group that may be substituted with a halogen atom or a C1-C6 alkyl group.
     &lt;2&gt; The 1,2,3-triazole derivative according to &lt;1&gt;, wherein in formula (1):   

     R is a C1-C6 alkyl group; 
     W 1  and W 2  are CH; 
     X is a hydrogen atom, a halogen atom, a cyano group, a C1-C6 alkyl group that may be substituted with a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkoxy group, a C1-C6 alkylcarbonyl group, a C1-C6 alkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 haloalkylthio group, a C1-C6 haloalkylsulfinyl group, a C1-C6 haloalkylsulfonyl group, a C1-C6 alkylamino group, a (C1-C6 alkoxy)carbonyl group, a di(C1-C6 alkyl)amino group, a (C1-C6 alkyl)carbonylamino group, a (C1-C6 alkyl)carbonyl(C1-C6 alkyl)amino group, an N—(C1-C6 alkyl)carbamoyl group, an N,N′-di(C1-C6 alkyl)carbamoyl group, a pentafluorosulfanyl group, or an aryl group that may be substituted with a halogen atom; 
     Q is a phenyl group or a pyridyl group, each of which may be substituted with one or more groups selected from the group consisting of a halogen atom, a cyano group, a nitro group, a C1-C6 alkyl group that may be substituted with a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkoxycarbonyl group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, a C1-C6 haloalkylcarbonyl group, a pentafluorosulfanyl group, a (C1-C6 alkyl)aminosulfonyl group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, a phenoxy group that may be substituted with a halogen atom or a C1-C6 alkyl group, and a benzoyl group that may be substituted with a halogen atom; and 
     Z is a hydrogen atom, a halogen atom, a cyano group, a C1-C6 alkyl group, a C3-C6 cycloalkyl group, or a C1-C6 haloalkyl group.
     &lt;3&gt; The 1,2,3-triazole derivative according to &lt;1&gt;, wherein in formula (1):   

     R is an ethyl group; 
     W 1  and W 2  are CH; 
     X is a hydrogen atom, a halogen atom, a cyano group, a C1-C6 alkyl group that may be substituted with a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkoxy group, a C1-C6 alkylcarbonyl group, a C1-C6 alkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 haloalkylthio group, a C1-C6 haloalkylsulfinyl group, a C1-C6 haloalkylsulfonyl group, a C1-C6 alkylamino group, a (C1-C6 alkoxy)carbonyl group, a di(C1-C6 alkyl)amino group, a (C1-C6 alkyl)carbonylamino group, a (C1-C6 alkyl)carbonyl(C1-C6 alkyl)amino group, an N—(C1-C6 alkyl)carbamoyl group, an N,N′-di(C1-C6 alkyl)carbamoyl group, a pentafluorosulfanyl group, or an aryl group that may be substituted with a halogen atom; 
     Q is a phenyl group that may be substituted with one or more groups selected from the group consisting of a halogen atom, a cyano group, a nitro group, a C1-C6 alkyl group that may be substituted with a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkoxycarbonyl group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, a C1-C6 haloalkylcarbonyl group, a pentafluorosulfanyl group, a (C1-C6 alkyl)aminosulfonyl group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, a phenoxy group that may be substituted with a halogen atom or a C1-C6 alkyl group, and a benzoyl group what may be substituted with a halogen atom; and 
     Z is a hydrogen atom, a halogen atom, or a C1-C6 alkyl group.
     &lt;4&gt; The 1,2,3-triazole derivative according to &lt;1&gt;, wherein in formula (1):   

     R is an ethyl group; 
     W 1  and W 2  are CH; 
     X is a hydrogen atom, a halogen atom, a cyano group, a C1-C6 alkyl group that may be substituted with a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkoxy group, a C1-C6 alkylcarbonyl group, a C1-C6 alkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 haloalkylthio group, a C1-C6 haloalkylsulfinyl group, a C1-C6 haloalkylsulfonyl group, a C1-C6 alkylamino group, a (C1-C6 alkoxy)carbonyl group, a di(C1-C6 alkyl)amino group, a (C1-C6 alkyl)carbonylamino group, a (C1-C6 alkyl)carbonyl(C1-C6 alkyl)amino group, an N—(C1-C6 alkyl)carbamoyl group, an N,N′-di(C1-C6 alkyl)carbamoyl group, a pentafluorosulfanyl group, or an aryl group that may be substituted with a halogen atom; 
     Q is a pyridyl group that may be substituted with one or more groups selected from the group consisting of a halogen atom, a cyano group, a C1-C6 alkyl group that may be substituted with a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, a C1-C6 haloalkylcarbonyl group, and a pentafluorosulfanyl group; and 
     Z is a hydrogen atom, a halogen atom, or a C1-C6 alkyl group.
     &lt;5&gt; An insecticide or acaricide containing the 1,2,3-triazole derivative according to any one of &lt;1&gt; to &lt;4&gt; as an active ingredient.   

     Effect of the Invention 
     The novel 1,2,3-triazole derivative of the present invention represented by formula (1) provides excellent insecticide or acaricide effects. 
    
    
     MODE FOR CARRYING OUT THE INVENTION 
     The 1,2,3-triazole derivative according to the compound of the present invention, the production method thereof, and the insecticide or acaricide containing the derivative as an active ingredient are described specifically below. 
     Here, the carbon number specified in each group below excludes carbon in the cyano group in the case of having a cyano group. In addition, the carbon number excludes also carbonyl carbon in a carbonyl-containing group such as C1-C6 alkylcarbonyl group and (C1-C6) alkoxycarbonyl group. 
     Incidentally, in the case where W 1  or W2 in formula (1) represents CH, when X is bonded to W 1  or W 2 , hydrogen atom in W 1  or W2 is replaced by X. 
     In the 1,2,3-triazole derivative represented by formula (1) of the present invention, examples of the halogen atom represented by X and Z include fluorine, chlorine, bromine, and iodine. 
     The C1-C6 alkyl group represented by R and Z may be either linear or branched, and examples thereof include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, an isobutyl group, a sec-butyl group, a tert-butyl group, a 1-pentyl group, an isoamyl group, a neopentyl group, a 2-pentyl group, a 3-pentyl group, a 2-methylbutyl group, a tert-pentyl group, and a 1-hexyl group. 
     The C1-C6 alkyl group that may be substituted with a hydroxyl group or a cyano group, represented by X, may be either linear or branched, and examples thereof include a methyl group, an ethyl group, an n-propyl group, an isopropyl group, an n-butyl group, an isobutyl group, a sec-butyl group, a tert-butyl group, a 1-pentyl group, an isoamyl group, a neopentyl group, a 2-pentyl group, a 3-pentyl group, a 2-methylbutyl group, a tert-pentyl group, a 1-hexyl group, a hydroxymethyl group, a cyanomethyl group, a 2-methylcyanomethyl group, a 2,2-dimethylcyanomethyl group, a 2-ethyl-2-methylcyanomethyl group, a 2,2-diethylcyanomethyl group, and a 2-cyanoethyl group. 
     Examples of the C3-C6 cycloalkyl group represented by Z include a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, and a cyclohexyl group. 
     Examples of the C3-C6 cycloalkyl group that may be substituted with a cyano group, represented by X, include a cyclopropyl group, a cyclobutyl group, a cyclopentyl group, a cyclohexyl group, a 1-cyanocyclopropyl group, and a 2-cyanocyclopropyl group. 
     Examples of the (C1-C6 alkoxy)C1-C6 fluoroalkyl group represented by X include a 1-methoxy-2,2,2-trifluoroethyl group, a 1-ethoxy-2,2,2-trifluoroethyl group, a 2-methoxy-1,1,1,3,3,3-hexafluoro-isopropyl group, and a 2-ethoxy-1,1,1,3,3,3-hexafluoroisopropyl group. 
     The C1-C6 alkoxy group represented by X and Z may be either linear or branched, and examples thereof include a methoxy group, an ethoxy group, an n-propyloxy group, an isopropyloxy group, an n-butyloxy group, an isobutyloxy group, a sec-butyloxy group, a tert-butyloxy group, a 1-pentyloxy group, an isoamyloxy group, a neopentyloxy group, a 2-pentyloxy group, a 3-pentyloxy group, a 2-methylbutyloxy group, a tert-pentyloxy group, and a hexyloxy group. 
     The C1-C6 alkylsulfonyloxy group represented by X may be either linear or branched, and examples thereof include a methylsulfonyloxy group, an ethylsulfonyloxy group, a propylsulfonyloxy group, an isopropylsulfonyloxy group, an n-butylsulfonyloxy group, an isobutylsulfonyloxy group, a sec-butylsulfonyloxy group, a tert-butylsulfonyloxy group, a 1-pentylsulfonyloxy group, an isoamylsulfonyloxy group, a neopentylsulfonyloxy group, a 2-pentylsulfonyloxy group, a 3-pentylsulfonyloxy group, a 2-methylbutylsulfonyloxy group, a tert-pentylsulfonyloxy group, and 1-hexylsulfonyloxy group. 
     The (C1-C6 alkoxy)C1-C6 alkoxy group represented by X may be either linear or branched, and examples thereof include a methoxymethoxy group, a methoxyethoxy group, an ethoxymethoxy group, an ethoxyethoxy group, a methoxypropoxy group, an ethoxypropoxy group, an n-propoxymethoxy group, an isopropoxymethoxy group, an n-butoxymethoxy group, a sec-butoxymethoxy group, a tert-butoxymethoxy group, a 1-pentyloxymethoxy group, and a 1-hexyloxymethoxy group. 
     The (C1-C6 alkoxy)C1-C6 alkyl group represented by Z may be either linear or branched, and examples thereof include a methoxymethyl group, a methoxyethyl group, an ethoxymethyl group, an ethoxyethyl group, an n-propoxymethyl group, an isopropoxymethyl group, an n-butoxymethyl group, a sec-butoxymethyl group, a tert-butoxymethyl group, a 1-pentyloxymethyl group, and a 1-hexyloxymethyl group. 
     The C1-C6 haloalkyl group that may be substituted with a cyano group, represented by X may be either linear or branched, and examples thereof include a monofluoromethyl group, a monochloromethyl group, a difluoromethyl group, a trifluoromethyl group, a 2,2,2-trifluoroethyl group, a 2-chloroethyl group, a 1-fluoroethyl group, a 2-fluoroethyl group, a 6-fluorohexyl group, a heptafluoroisopropyl group, a 1,1,1,3,3,3-hexafluoro-isopropyl group, and a (cyano)difluoromethyl group. 
     The C1-C6 haloalkyl group represented by R and Z may be either linear or branched, and examples thereof include a monofluoromethyl group, a difluoromethyl group, a trifluoromethyl group, a 2,2,2-trifluoroethyl group, a 2-chloroethyl group, a 1-fluoroethyl group, a 2-fluoroethyl group, a 6-fluorohexyl group, and a heptafluoroisopropyl group. 
     Examples of the C1-C6 haloalkoxy group represented by X include a trifluoromethoxy group, a 2,2,2-trifluoroethoxy group, a 2-chloroethoxy group, and a 1,1,2,2-tetrafluoroethoxy group. 
     The C1-C6 alkylcarbonyl group represented by X may be either linear or branched, and examples thereof include an acetyl group, an ethylcarbonyl group, an n-propylcarbonyl group, an isopropylcarbonyl group, an n-butylcarbonyl group, an isobutylcarbonyl group, a sec-butylcarbonyl group, tert-butylcarbonyl group, a 1-pentylcarbonyl group, and a 1-hexylcarbonyl group. 
     Examples of the C1-C6 haloalkylsulfonyloxy group represented by X include a difluoromethylsulfonyloxy group, a trifluoromethylsulfonyloxy group, a chloromethylsulfonyloxy group, a trichloromethylsulfonyloxy group, and 2-chloroethylsulfonyloxy group. 
     The C1-C6 alkylthio group represented by X and Z may be either linear or branched, and examples thereof include a methylthio group, an ethylthio group, an n-propylthio group, an isopropylthio group, an n-butylthio group, an isobutylthio group, a sec-butylthio group, a tert-butylthio group, a 1-pentylthio group, an isoamylthio group, a neopentylthio group, a 2-pentylthio group, a 3-pentylthio group, a 2-methylbutylthio group, a tert-pentylthio group, and a 1-hexylthio group. 
     The C1-C6 alkylsulfinyl group represented by X may be either linear or branched, and examples thereof include a methylsulfinyl group, an ethylsulfinyl group, an n-propylsulfinyl group, an isopropylsulfinyl group, an n-butylsulfinyl group, an isobutylsulfinyl group, a sec-butylsulfinyl group, a tert-butylsulfinyl group, a 1-pentylsulfinyl group, an isoamylsulfinyl group, a neopentylsulfinyl group, a 2-pentylsulfinyl group, a 3-pentylsulfinyl group, a 2-methylbutylsulfinyl group, a tert-pentylsulfinyl group, and a 1-hexylsulfinyl group. 
     The C1-C6 alkylsulfonyl group represented by X may be either linear or branched, and examples thereof include a methylsulfonyl group, an ethylsulfonyl group, an n-propylsulfonyl group, an isopropylsulfonyl group, an n-butylsulfonyl group, an isobutylsulfonyl group, a sec-butylsulfonyl group, a tert-butylsulfonyl group, a 1-pentylsulfonyl group, an isoamylsulfonyl group, a neopentylsulfonyl group, a 2-pentylsulfonyl group, a 3-pentylsulfonyl group, a 2-methylbutylsulfonyl group, a tert-pentylsulfonyl group, and a 1-hexylsulfonyl group. 
     Examples of the C1-C6 haloalkylthio group represented by X and Z include a monofluoromethylthio group, a difluoromethylthio group, a trifluoromethylthio group, a 2,2,2-trifluoroethylthio group, and a 2,2,2-trichloroethylthio group. 
     Examples of the C1-C6 haloalkylsulfinyl group represented by X include a monofluoromethylsulfinyl group, a difluoromethylsulfinyl group, a trifluoromethylsulfinyl group, a 2,2,2-trifluoroethylsulfinyl group, and a 2,2,2-trichloroethylsulfinyl group. 
     Examples of the C1-C6 haloalkylsulfonyl group represented by X include a monofluoromethylsulfonyl group, a difluoromethylsulfonyl group, a trifluoromethylsulfonyl group, a 2,2,2-trifluoroethylsulfonyl group, and a 2,2,2-trichloroethylsulfonyl group. 
     The C1-C6 alkylamino group represented by X and Z may be either linear or branched, and examples thereof include a methylamino group, an ethylamino group, an isopropylamino group, an isobutylamino group, a 1-pentylamino group, and a 1-hexylamino group. 
     The (C1-C6 alkoxy)carbonyl group represented by X and Z may be either linear or branched, and examples thereof include a methoxycarbonyl group, an ethoxycarbonyl group, an n-propoxycarbonyl group, an isopropoxycarbonyl group, an n-butoxycarbonyl group, a sec-butoxycarbonyl group, a tert-butoxycarbonyl group, and an n-hexyloxycarbonyl group. 
     The di(C1-C6 alkyl)amino group represented by X and Z may be either linear or branched, and examples thereof include a dimethylamino group, a diethylamino group, an N-ethyl-N′-methylamino group, a di(isopropyl)amino group, a di(n-butyl)amino group, a di(n-pentyl)amino group, and a di(n-hexyl)amino group. 
     The (C1-C6 alkyl)carbonylamino group represented by X and Z may be either linear or branched, and examples thereof include an acetylamino group, an ethylcarbonylamino group, an n-propylcarbonylamino group, an isopropylcarbonylamino group, and a tert-butylcarbonylamino group. 
     The (C1-C6 alkyl)carbonyl(C1-C6 alkyl)amino group represented by X may be either linear or branched, and examples thereof include an N-(methyl)acetylamino group, an N-(ethyl)-n-propylcarbonylamino group, an N-(ethyl)isopropylcarbonylamino group, and an N-(ethyl)-tert-butylcarbonylamino group. 
     The N—(C1-C6 alkyl)carbamoyl group represented by X and Z may be either linear or branched, and examples thereof include an N-methylcarbamoyl group, an N-ethylcarbamoyl group, an N-(n-propyl)carbamoyl group, an N-isopropylcarbamoyl group, and an N-(n-hexyl)carbamoyl group. 
     The N,N′-di(C1-C6 alkyl)carbamoyl group represented by X and Z may be either linear or branched, and examples thereof include an N,N′-dimethylcarbamoyl group, an N,N′-diethylcarbamoyl group, an N-ethyl-N′-methylcarbamoyl group, and an N-ethyl-N′-isopropylcarbamoyl group. 
     The triazolyl group that may be substituted with a C1-C6 alkyl group, represented by X, may be either linear or branched, and examples thereof include a 1,2,4-triazol-3-yl group, a 1-methyl-1,2,4-triazol-3-yl group, a 1-ethyl-1,2,4-triazol-3-yl group, a 1-(n-propyl)-1,2,4-triazol-3-yl group, and a 1-isopropyl-1,2,4-triazol-3-yl group. 
     The oxadiazolyl group that may be substituted with a C1-C6 alkyl group, represented by X, may be either linear or branched, and examples thereof include a 1,2,4-oxadiazol-3-yl group, a 5-methyl-1,2,4-oxadiazol-3-yl group, a 5-ethyl-1,2,4-oxadiazol-3-yl group, a 5-(n-propyl)-1,2,4-oxadiazol-3-yl group, and a 5-isopropyl-1,2,4-oxadiazol-3-yl group. 
     The tetrazolyl group that may be substituted with a C1-C6 alkyl group, represented by X, may be either linear or branched, and examples thereof include a tetrazol-5-yl group, a 1-methyltetrazol-5-yl group, a 1-ethyltetrazol-5-yl group, a 1-(n-propyl)-tetrazol-5-yl group, a 1-isopropyltetrazol-5-yl group, a 2-methyltetrazol-5-yl group, a 2-ethyltetrazol-5-yl group, a 2-(n-propyl)-tetrazol-5-yl group, and a 2-isopropyltetrazol-5-yl group. 
     Examples of the (tetrazolyl that may be substituted with a C1-C6 haloalkyl group)C1-C6 alkyl group, represented by X, include a (5-trifluoromethyltetrazol-2-yl)methyl group and a (5-pentafluoroethyltetrazol-2-yl)methyl group. 
     Examples of the benzoyl group that may be substituted with a halogen atom, represented by X, include a benzoyl group, a 2-fluorobenzoyl group, a 3-fluorobenzoyl group, a 4-fluorobenzoyl group, a 2-chlorobenzoyl group, a 3-chlorobenzoyl group, a 4-chlorobenzoyl group, a 2-bromobenzoyl group, a 3-bromobenzoyl group, a 4-bromobenzoyl group, a 2-iodobenzoyl group, a 3-iodobenzoyl group, a 4-iodobenzoyl group, a 2,4-dichlorobenzoyl group, a 2,6-dichlorobenzoyl group, a 3,4-dichlorobenzoyl group, and a 3,5-dichlorobenzoyl group. 
     Examples of the arylsulfonyl group that may be substituted with a halogen atom, represented by X, include a phenylsulfonyl group, a 2-fluorophenylsulfonyl group, a 3-fluorophenylsulfonyl group, a 4-fluorophenylsulfonyl group, a 2-chlorophenylsulfonyl group, a 3-chlorophenylsulfonyl group, a 4-chlorophenylsulfonyl group, a 2-bromophenylsulfonyl group, a 3-bromophenylsulfonyl group, a 4-bromophenylsulfonyl group, a 2-iodophenylsulfonyl group, a 3-iodophenylsulfonyl group, a 4-iodophenylsulfonyl group, a 2,4-dichlorophenylsulfonyl group, a 2,6-dichlorophenylsulfonyl group, a 3,4-dichlorophenylsulfonyl group, a 3,5-dichlorophenylsulfonyl group, a 2-pyridylsulfonyl group, a 5-chloro-2-pyridylsulfonyl group, a 5-trifluoromethyl-2-pyridylsulfonyl group, a 3-chloro-5-trifluoromethyl-2-pyridylsulfonyl group, a 3-pyridylsulfonyl group, a 6-chloro-3-pyridylsulfonyl group, and a 4-pyridylsulfonyl group. 
     Examples of the arylsulfinyl group that may be substituted with a halogen atom, represented by X, include a phenylsulfinyl group, a 2-fluorophenylsulfinyl group, a 3-fluorophenylsulfinyl group, a 4-fluorophenylsulfinyl group, a 2-chlorophenylsulfinyl group, a 3-chlorophenylsulfinyl group, a 4-chlorophenylsulfinyl group, a 2-bromophenylsulfinyl group, a 3-bromophenylsulfinyl group, a 4-bromophenylsulfinyl group, a 2-iodophenylsulfinyl group, a 3-iodophenylsulfinyl group, a 4-iodophenylsulfinyl group, a 2,4-dichlorophenylsulfinyl group, a 2,6-dichlorophenylsulfinyl group, a 3,4-dichlorophenylsulfinyl group, a 3,5-dichlorophenylsulfinyl group, a 2-pyridylsulfinyl group, a 5-chloro-2-pyridylsulfinyl group, a 5-trifluoromethyl-2-pyridylsulfinyl group, a 3-chloro-5-trifluoromethyl-2-pyridylsulfinyl group, a 3-pyridylsulfinyl group, a 6-chloro-3-pyridylsulfinyl group, and a 4-pyridylsulfinyl group. 
     Examples of the arylthio group that may be substituted with a halogen atom, represented by X, include a phenylthio group, a 2-fluorophenylthio group, a 3-fluorophenylthio group, a 4-fluorophenylthio group, a 2-chlorophenylthio group, a 3-chlorophenylthio group, a 4-chlorophenylthio group, a 2-bromophenylthio group, a 3-bromophenylthio group, a 4-bromophenylthio group, a 2-iodophenylthio group, a 3-iodophenylthio group, a 4-iodophenylthio group, a 2,4-dichlorophenylthio group, a 2,6-dichlorophenylthio group, a 3,4-dichlorophenylthio group, a 3,5-dichlorophenylthio group, a 2-pyridylthio group, a 5-chloro-2-pyridylthio group, a 5-trifluoromethyl-2-pyridylthio group, a 3-chloro-5-trifluoromethyl-2-pyridylthio group, a 3-pyridylthio group, a 6-chloro-3-pyridylthio group, and a 4-pyridylthio group. 
     Examples of the arylamino group that may be substituted with a halogen atom, represented by X, include a phenylamino group, a 2-fluorophenylamino group, a 3-fluorophenylamino group, a 4-fluorophenylamino group, a 2-chlorophenylamino group, a 3-chlorophenylamino group, a 4-chlorophenylamino group, a 2-bromophenylamino group, a 3-bromophenylamino group, a 4-bromophenylamino group, a 2-iodophenylamino group, a 3-iodophenylamino group, a 4-iodophenylamino group, a 2,4-dichlorophenylamino group, a 2,6-dichlorophenylamino group, a 3,4-dichlorophenylamino group, a 3,5-dichlorophenylamino group, a 2-pyridylamino group, a 5-chloro-2-pyridylamino group, a 5-trifluoromethyl-2-pyridylamino group, a 3-chloro-5-trifluoromethyl-2-pyridylamino group, a 3-pyridylamino group, a 6-chloro-3-pyridylamino group, and a 4-pyridylamino group. 
     Examples of the aryloxy group that may be substituted with a halogen atom, represented by X, include a phenoxy group, a 2-fluorophenoxy group, a 3-fluorophenoxy group, a 4-fluorophenoxy group, a 2-chlorophenoxy group, a 3-chlorophenoxy group, a 4-chlorophenoxy group, a 2-bromophenoxy group, a 3-bromophenoxy group, a 4-bromophenoxy group, a 2-iodophenoxy group, a 3-iodophenoxy group, a 4-iodophenoxy group, a 2,4-dichlorophenoxy group, a 2,6-dichlorophenoxy group, a 3,4-dichlorophenoxy group, a 3,5-dichlorophenoxy group, a 2-pyridyloxy group, a 5-chloro-2-pyridyloxy group, a 5-trifluoromethyl-2-pyridyloxy group, a 3-chloro-5-trifluoromethyl-2-pyridyloxy group, a 3-pyridyloxy group, a 6-chloro-3-pyridyloxy group, and a 4-pyridyloxy group. 
     Examples of the aryl group that may be substituted with a halogen atom, represented by X, include a phenyl group, a 2-fluorophenyl group, a 3-fluorophenyl group, a 4-fluorophenyl group, a 2-chlorophenyl group, a 3-chlorophenyl group, a 4-chlorophenyl group, a 2-bromophenyl group, a 3-bromophenyl group, a 4-bromophenyl group, a 2-iodophenyl group, a 3-iodophenyl group, a 4-iodophenyl group, a 2,4-dichlorophenyl group, a 2,6-dichlorophenyl group, a 3,4-dichlorophenyl group, a 3,5-dichlorophenyl group, a 2-pyridyl group, a 5-chloro-2-pyridyl group, a 5-trifluoromethyl-2-pyridyl group, a 3-chloro-5-trifluoromethyl-2-pyridyl group, a 3-pyridyl group, a 6-chloro-3-pyridyl group, and a 4-pyridyl group. 
     Examples of the N—(C1-C6 haloalkyl)carbamoyl group represented by Z include an N-(2,2,2-trifluoroethyl)carbamoyl group and an N-(3,3,3-trifluoropropyl)carbamoyl group. 
     The N,N′-di(C1-C6 alkyl)carbonylamino group represented by Z may be either linear or branched, and examples thereof include an N,N′-diacetylamino group, an N-acetyl-N′-ethylcarbonylamino group, an N,N′-diethylcarbonylamino group, an N-acetyl-N′-(n-propyl)carbonylamino group, and an N-acetyl-N′-isopropylcarbonylamino group. 
     Examples of the N-(phenyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, represented by Z, include an N-(phenyl)carbamoyl group, an N-(2-chlorophenyl)carbamoyl group, an N-(3-chlorophenyl)carbamoyl group, an N-(4-chlorophenyl)carbamoyl group, an N-(2-methylphenyl)carbamoyl group, an N-(3-methylphenyl)carbamoyl group, and an N-(4-methylphenyl)carbamoyl group. 
     Examples of the (C1-C6 haloalkyl)carbonylamino group represented by Z include a trifluoromethylcarbonylamino group, a (2,2,2-trifluoroethyl)carbonylamino group, and a (3,3,3-trifluoropropyl)carbonylamino group. 
     Examples of the arylcarbonylamino group that may be substituted with a halogen atom or a C1-C6 alkyl group, represented by Z, include a benzoylamino group, a 2-chlorobenzoylamino group, a 3-chlorobenzoylamino group, a 4-chlorobenzoylamino group, a 2-methylbenzoylamino group, a 3-methylbenzoylamino group, and a 4-methylbenzoylamino group. 
     Examples of the phenyl group represented by Q, which may be substituted with one or more groups selected from the group consisting of a halogen atom, a cyano group, a nitro group, a carboxyl group, a C1-C6 alkyl group that may be substituted with a hydroxyl group or a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkyl group {substituted with an N-carbamoyl group (that may be substituted with a C1-C6 alkyl group)}, a C1-C6 haloalkyl group {substituted with an N-arylcarbamoyl group (that may be substituted with a halogen atom or a C1-C6 alkyl group)}, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkoxycarbonyl group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, a C1-C6 haloalkylcarbonyl group, a pentafluorosulfanyl group, an N—(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 haloalkyl)carbamoyl group, an N-(phenyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N-(pyridyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N,N′-di(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 alkylcarbonyl)amino group, an N—(C1-C6 haloalkylcarbonyl)amino group, an N—(C1-C6 alkoxycarbonyl)amino group, an N—(C1-C6 haloalkoxycarbonyl)amino group, a C1-C6 alkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a C1-C6 haloalkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group and the phenyl group may be substituted with a halogen atom or a C1-C6 alkyl group, a (C1-C6 alkyl)aminosulfonyl group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, a phenoxy group that may be substituted with a halogen atom or a C1-C6 alkyl group, and a benzoyl group that may be substituted with a halogen atom, include a phenyl group, a 2-fluorophenyl group, a 3-fluorophenyl group, a 4-fluorophenyl group, a 2-chlorophenyl group, a 3-chlorophenyl group, a 4-chlorophenyl group, a 2-bromophenyl group, a 3-bromophenyl group, a 4-bromophenyl group, a 2-methylphenyl group, a 3-methylphenyl group, a 4-methylphenyl group, a 2-cyclopropylphenyl group, a 3-cyclopropylphenyl group, a 4-cyclopropylphenyl group, a 2-methoxyphenyl group, a 3-methoxyphenyl group, a 4-methoxyphenyl group, a 3-trifluoromethoxyphenyl group, a 4-cyanophenyl group, a 4-phenoxyphenyl group, a 2-(trifluoromethyl)phenyl group, a 3-(trifluoromethyl)phenyl group, a 4-(trifluoromethyl)phenyl group, a 3-pentafluorosulfanylphenyl group, a 3,5-dichlorophenyl group, a 2-chloro-4-(trifluoromethyl)phenyl group, a 3-(trifluoromethyl)-4-chlorophenyl group, a 3,5-bis(trifluoromethyl)phenyl group, a 2,5-bis(trifluoromethyl)phenyl group, a 2,4-bis(trifluoromethyl)phenyl group, a 3,4-bis(trifluoromethyl)phenyl group, a 4-(perfluoroisopropyl)phenyl group, a 2-chloro-3,5-bis(trifluoromethyl)phenyl group, a 2-fluoro-3,5-bis(trifluoromethyl)phenyl group, a 3-chloro-5-(trifluoromethyl)phenyl group, a 3-fluoro-5-(trifluoromethyl)phenyl group, a 3-bromo-5-(trifluoromethyl)phenyl group, a 3-methyl-5-(trifluoromethyl)phenyl group, a 3-acetyl-5-(trifluoromethyl)phenyl group, a 3-trifluoroacetyl-5-(trifluoromethyl)phenyl group, a 3-cyano-5-(trifluoromethyl)phenyl group, a 3-cyanomethyl-5-(trifluoromethyl)phenyl group, a 3-cyclopropyl-5-(trifluoromethyl)phenyl group, a 3-(1-cyanocyclopropyl)-5-(trifluoromethyl)phenyl group, a 3-trifluoromethoxy-5-(trifluoromethyl)phenyl group, a 3-methylthio-5-(trifluoromethyl)phenyl group, a 3-methylsulfinyl-5-(trifluoromethyl)phenyl group, a 3-methylsulfonyl-5-(trifluoromethyl)phenyl group, a 3-trifluoromethylthio-5-(trifluoromethyl)phenyl group, a 3-methoxycarbonyl-5-(trifluoromethyl)phenyl group, a 3-ethoxycarbonyl-5-(trifluoromethyl)phenyl group, a 3-methylcarbamoyl-5-(trifluoromethyl)phenyl group, a 3-(N-methylcarbamoyl)difluoromethyl-5-(trifluoromethyl)phenyl group, a 3-(N-phenylcarbamoyl)difluoromethyl-5-(trifluoromethyl)phenyl group, a 3-phenylaminocarbonyl-5-(trifluoromethyl)phenyl group, a 3-(2-pyridylamino)carbonyl-5-(trifluoromethyl)phenyl group, a 3-(3-pyridylamino)carbonyl-5-(trifluoromethyl)phenyl group, a 3-(4-pyridylamino)carbonyl-5-(trifluoromethyl)phenyl group, a 3-(tert-butoxycarbonylamino)-5-(trifluoromethyl)phenyl group, a 3-(trifluoroacetylamino)-5-(trifluoromethyl)phenyl group, a 3-(trifluoromethylsulfonylamino)-5-(trifluoromethyl)phenyl group, a 3-phenyl-5-(trifluoromethyl)phenyl group, a 3-phenoxy-5-(trifluoromethyl)phenyl group, a 3-cyanodifluoromethyl-5-(trifluoromethyl)phenyl group, a 4-tert-butylphenyl group, a 4-biphenyl group, a 4-chloro-3,5-bis(trifluoromethyl)phenyl group, a 4-methyl-3,5-bis(trifluoromethyl)phenyl group, a 3-{N-(4-chlorophenyl)carbamoyl}-5-(trifluoromethyl)phenyl group, a 3-carbamoyldifluoromethyl-5-(trifluoromethyl)phenyl group, a 3-trifluoromethyl-5-(methylaminocarbonyldifluoromethyl)phenyl group, a 3-benzoyl-5-(trifluoromethyl)phenyl group, a 3-trifluoromethyl-5-{(N-phenylcarbamoyl)difluoromethyl}phenyl group, a 3-(1,1′-difluoroethyl)-5-(trifluoromethyl)phenyl group, a 2-fluoro-5-(trifluoromethyl)phenyl group, and a 3-carboxyl-5-(trifluoromethyl)phenyl group. 
     Examples of the pyridyl group represented by Q, which may be substituted with one or more groups selected from the group consisting of a halogen atom, a cyano group, a nitro group, a carboxyl group, a C1-C6 alkyl group that may be substituted with a hydroxyl group or a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkyl group {substituted with an N-carbamoyl group (that may be substituted with a C1-C6 alkyl group)}, a C1-C6 haloalkyl group {substituted with an N-arylcarbamoyl group (that may be substituted with a halogen atom or a C1-C6 alkyl group)}, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkoxycarbonyl group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, a C1-C6 haloalkylcarbonyl group, a pentafluorosulfanyl group, an N—(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 haloalkyl)carbamoyl group, an N-(phenyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N-(pyridyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N,N′-di(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 alkylcarbonyl)amino group, an N—(C1-C6 haloalkylcarbonyl)amino group, an N—(C1-C6 alkoxycarbonyl)amino group, an N—(C1-C6 haloalkoxycarbonyl)amino group, a C1-C6 alkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a C1-C6 haloalkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group and the phenyl group may be substituted with a halogen atom or a C1-C6 alkyl group, a (C1-C6 alkyl)aminosulfonyl group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, a phenoxy group that may be substituted with a halogen atom or a C1-C6 alkyl group, and a benzoyl group that may be substituted with a halogen atom, include a 2-pyridyl group, a 3-pyridyl group, a 4-pyridyl group, a 6-chloro-2-pyridyl group, a 2-chloro-3-pyridyl group, a 2-chloro-4-pyridyl group, a 6-bromo-2-pyridyl group, a 5-bromo-3-pyridyl group, a 2-bromo-4-pyridyl group, a 6-methyl-2-pyridyl group, a 4-methyl-2-pyridyl group, a 4-chloro-2-pyridyl group, a 4-cyano-2-pyridyl group, a 2-methyl-4-pyridyl group, a 2-trifluoromethyl-4-pyridyl group, a 6-cyclopropyl-3-pyridyl group, a 6-methoxy-2-pyridyl group, a 6-methoxy-3-pyridyl group, a 3-trifluoromethyl-2-pyridyl group, a 4-trifluoromethyl-2-pyridyl group, a 5-trifluoromethyl-2-pyridyl group, a 6-trifluoromethyl-2-pyridyl group, a 4-pentafluoroethyl-2-pyridyl group, a 5-pentafluoroethyl-3-pyridyl group, a 4-pentafluorosulfanyl-2-pyridyl group, a 4,6-bistrifluoromethyl-2-pyridyl group, a 2,5-bistrifluoromethyl-4-pyridyl group, a 3-chloro-5-trifluoromethyl-2-pyridyl group, a 3-cyano-4,6-bistrifluoromethyl-2-pyridyl group, a 3-chloro-4-trifluoromethyl-2-pyridyl group, a 4-trifluoromethyl-5-chloro-2-pyridyl group, a 4-trifluoromethyl-6-chloro-2-pyridyl group, a 4-trifluoromethyl-3-bromo-2-pyridyl group, a 4-trifluoromethyl-5-bromo-2-pyridyl group, a 4-trifluoromethyl-6-bromo-2-pyridyl group, a 3,5-dichloro-4-trifluoromethyl-2-pyridyl group, a 3-fluoro-4-trifluoromethyl-2-pyridyl group, a 4-trifluoromethyl-5-fluoro-2-pyridyl group, a 4-trifluoromethyl-6-fluoro-2-pyridyl group, a 3,5-difluoro-4-trifluoromethyl-2-pyridyl group, a 4-trifluoromethyl-6-methoxy-2-pyridyl group, a 4-trifluoromethyl-6-cyano-2-pyridyl group, a 4-trifluoromethyl-6-cyclopropyl-2-pyridyl group, a 4-trifluoromethyl-3-pyridyl group, a 5-trifluoromethyl-3-pyridyl group, a 6-trifluoromethyl-3-pyridyl group, a 2-fluoro-5-trifluoromethyl-3-pyridyl group, a 3-trifluoromethyl-4-pyridyl group, a 4-trifluoromethoxy-2-pyridyl group, a 5-trifluoromethoxy-2-pyridyl group, a 5-methylthio-2-pyridyl group, a 4-methylthio-2-pyridyl group, a 5-methylsulfinyl-2-pyridyl group, a 4-methylsulfinyl-2-pyridyl group, a 5-methylsulfonyl-2-pyridyl group, a 4-methylsulfonyl-2-pyridyl group, a 4-trifluoromethylthio-2-pyridyl group, a 4-trifluoromethylsulfinyl-2-pyridyl group, a 4-trifluoromethylsulfonyl-2-pyridyl group, a 3-N-methylcarbamoyl-2-pyridyl group, a 3-N-(2,2,2-trifluoroethyl)carbamoyl-2-pyridyl group, a 3-N,N′-dimethylcarbamoyl-2-pyridyl group, a 3-methyl sulfonylamino-2-pyridyl group, a 5-trifluoromethyl sulfonylamino-2-pyridyl group, a 5-phenylsulfonylamino-2-pyridyl group, and a 5-methylaminosulfonyl-2-pyridyl group. 
     Examples of the thiazolyl group represented by Q, which may be substituted with one or more groups selected from the group consisting of a halogen atom, a cyano group, a nitro group, a carboxyl group, a C1-C6 alkyl group that may be substituted with a hydroxyl group or a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkyl group {substituted with an N-carbamoyl group (that may be substituted with a C1-C6 alkyl group)}, a C1-C6 haloalkyl group {substituted with an N-arylcarbamoyl group (that may be substituted with a halogen atom or a C1-C6 alkyl group)}, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkoxycarbonyl group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, a C1-C6 haloalkylcarbonyl group, a pentafluorosulfanyl group, an N—(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 haloalkyl)carbamoyl group, an N-(phenyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N-(pyridyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N,N′-di(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 alkylcarbonyl)amino group, an N—(C1-C6 haloalkylcarbonyl)amino group, an N—(C1-C6 alkoxycarbonyl)amino group, an N—(C1-C6 haloalkoxycarbonyl)amino group, a C1-C6 alkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a C1-C6 haloalkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group and the phenyl group may be substituted with a halogen atom or a C1-C6 alkyl group, a (C1-C6 alkyl)aminosulfonyl group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, a phenoxy group that may be substituted with a halogen atom or a C1-C6 alkyl group, and a benzoyl group that may be substituted with a halogen atom, include a 2-thiazolyl group, a 4-methylthiazol-2-yl group, a 4-trifluoromethylthiazol-2-yl group, a 4-chlorothiazol-2-yl group, a 4,5-dimethylthiazol-2-yl group, and a 5-trifluoromethylthiazol-2-yl group. 
     Examples of the quinolyl group represented by Q, which may be substituted with one or more groups selected from the group consisting of a halogen atom, a cyano group, a nitro group, a carboxyl group, a C1-C6 alkyl group that may be substituted with a hydroxyl group or a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkyl group {substituted with an N-carbamoyl group (that may be substituted with a C1-C6 alkyl group)}, a C1-C6 haloalkyl group {substituted with an N-arylcarbamoyl group (that may be substituted with a halogen atom or a C1-C6 alkyl group)}, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkoxycarbonyl group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, a C1-C6 haloalkylcarbonyl group, a pentafluorosulfanyl group, an N—(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 haloalkyl)carbamoyl group, an N-(phenyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N-(pyridyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N,N′-di(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 alkylcarbonyl)amino group, an N—(C1-C6 haloalkylcarbonyl)amino group, an N—(C1-C6 alkoxycarbonyl)amino group, an N—(C1-C6 haloalkoxycarbonyl)amino group, a C1-C6 alkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a C1-C6 haloalkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group and the phenyl group may be substituted with a halogen atom or a C1-C6 alkyl group, a (C1-C6 alkyl)aminosulfonyl group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, a phenoxy group that may be substituted with a halogen atom or a C1-C6 alkyl group, and a benzoyl group that may be substituted with a halogen atom, include a 2-quinolyl group, a 3-quinolyl group, a 4-quinolyl group, a 5-quinolyl group, a 6-quinolyl group, a 7-quinolyl group, a 8-quinolyl group, a 4-methyl-2-quinolyl group, a 4-trifluoromethyl-2-quinolyl group, a 8-trifluoromethyl-2-quinolyl group, a 4-chloro-6-quinolyl group, and a 4-cyano-8-trifluoromethyl-6-quinolyl group. 
     Examples of the benzoxazolyl group represented by Q, which may be substituted with one or more groups selected from the group consisting of a halogen atom, a cyano group, a nitro group, a carboxyl group, a C1-C6 alkyl group that may be substituted with a hydroxyl group or a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkyl group {substituted with an N-carbamoyl group (that may be substituted with a C1-C6 alkyl group)}, a C1-C6 haloalkyl group {substituted with an N-arylcarbamoyl group (that may be substituted with a halogen atom or a C1-C6 alkyl group)}, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkoxycarbonyl group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, a C1-C6 haloalkylcarbonyl group, a pentafluorosulfanyl group, an N—(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 haloalkyl)carbamoyl group, an N-(phenyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N-(pyridyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N,N′-di(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 alkylcarbonyl)amino group, an N—(C1-C6 haloalkylcarbonyl)amino group, an N—(C1-C6 alkoxycarbonyl)amino group, an N—(C1-C6 haloalkoxycarbonyl)amino group, a C1-C6 alkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a C1-C6 haloalkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group and the phenyl group may be substituted with a halogen atom or a C1-C6 alkyl group, a (C1-C6 alkyl)aminosulfonyl group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, a phenoxy group that may be substituted with a halogen atom or a C1-C6 alkyl group, and a benzoyl group that may be substituted with a halogen atom, include a 2-benzoxazolyl group, a 5-methylbenzoxazol-2-yl group, a 5-methoxybenzoxazol-2-yl group, a 5-fluorobenzoxazol-2-yl group, a 5-chlorobenzoxazol-2-yl group, a 5-bromobenzoxazol-2-yl group, a 5-trifluoromethylbenzoxazol-2-yl group, a 6-methylbenzoxazol-2-yl group, and a 6-fluorobenzoxazol-2-yl group. 
     Examples of the benzothiazolyl group represented by Q, which may be substituted with one or more groups selected from the group consisting of a halogen atom, a cyano group, a nitro group, a carboxyl group, a C1-C6 alkyl group that may be substituted with a hydroxyl group or a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkyl group {substituted with an N-carbamoyl group (that may be substituted with a C1-C6 alkyl group)}, a C1-C6 haloalkyl group {substituted with an N-arylcarbamoyl group (that may be substituted with a halogen atom or a C1-C6 alkyl group)}, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkoxycarbonyl group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, a C1-C6 haloalkylcarbonyl group, a pentafluorosulfanyl group, an N—(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 haloalkyl)carbamoyl group, an N-(phenyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N-(pyridyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N,N′-di(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 alkylcarbonyl)amino group, an N—(C1-C6 haloalkylcarbonyl)amino group, an N—(C1-C6 alkoxycarbonyl)amino group, an N—(C1-C6 haloalkoxycarbonyl)amino group, a C1-C6 alkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a C1-C6 haloalkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group and the phenyl group may be substituted with a halogen atom or a C1-C6 alkyl group, a (C1-C6 alkyl)aminosulfonyl group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, a phenoxy group that may be substituted with a halogen atom or a C1-C6 alkyl group, and a benzoyl group that may be substituted with a halogen atom, include a 2-benzothiazolyl group, a 5-methylbenzothiazol-2-yl group, a 5-methoxybenzothiazol-2-yl group, a 5-fluorobenzothiazol-2-yl group, a 5-chlorobenzothiazol-2-yl group, a 5-bromobenzothiazol-2-yl group, a 5-trifluoromethylbenzothiazol-2-yl group, a 6-trifluoromethylbenzothiazol-2-yl group, a 6-methylbenzothiazol-2-yl group, and a 6-fluorobenzothiazol-2-yl group. 
     Examples of the benzimidazolyl represented by Q, which may be substituted with one or more groups selected from the group consisting of a halogen atom, a cyano group, a nitro group, a carboxyl group, a C1-C6 alkyl group that may be substituted with a hydroxyl group or a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkyl group {substituted with an N-carbamoyl group (that may be substituted with a C1-C6 alkyl group)}, a C1-C6 haloalkyl group {substituted with an N-arylcarbamoyl group (that may be substituted with a halogen atom or a C1-C6 alkyl group)}, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkoxycarbonyl group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, a C1-C6 haloalkylcarbonyl group, a pentafluorosulfanyl group, an N—(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 haloalkyl)carbamoyl group, an N-(phenyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N-(pyridyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N,N′-di(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 alkylcarbonyl)amino group, an N—(C1-C6 haloalkylcarbonyl)amino group, an N—(C1-C6 alkoxycarbonyl)amino group, an N—(C1-C6 haloalkoxycarbonyl)amino group, a C1-C6 alkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a C1-C6 haloalkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group and the phenyl group may be substituted with a halogen atom or a C1-C6 alkyl group, a (C1-C6 alkyl)aminosulfonyl group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, a phenoxy group that may be substituted with a halogen atom or a C1-C6 alkyl group, and a benzoyl group that may be substituted with a halogen atom, include a 1-methyl-2-benzimidazolyl group, a 1,5-dimethyl-2-benzimidazolyl group, a 1-methyl-5-methoxy-2-benzimidazol-2-yl group, a 1-methyl-5-chloro-2-benzimidazol-2-yl group, a 1-methyl-5-bromobenzimidazol-2-yl group, a 1-methyl-5-trifluoromethylbenzimidazol-2-yl group, a 1-methyl-6-trifluoromethylbenzimidazol-2-yl group, a 1-methyl-6-chlorobenzimidazol-2-yl group, and a 1,6-dimethyl-2-benzimidazolyl group. 
     R in formula (1) is preferably a C1-C6 alkyl group, more preferably an ethyl group. 
     W 1  and W 2  in formula (1) are more preferably CH. 
     X in formula (1) is preferably a hydrogen atom, a halogen atom, a cyano group, a hydroxyl group, a carboxyl group, a C1-C6 alkyl group that may be substituted with a hydroxyl group or a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a (C1-C6 alkoxy)C1-C6 fluoroalkyl group, a C1-C6 alkoxy group, a (C1-C6 alkoxy)C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkoxy group, a C1-C6 alkylcarbonyl group, a C1-C6 haloalkylsulfonyloxy group, a C1-C6 alkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 haloalkylthio group, a C1-C6 haloalkylsulfinyl group, a C1-C6 haloalkylsulfonyl group, a C1-C6 alkylamino group, a (C1-C6 alkoxy)carbonyl group, a di(C1-C6 alkyl)amino group, a (C1-C6 alkyl)carbonylamino group, a (C1-C6 alkyl)carbonyl(C1-C6 alkyl)amino group, an N—(C1-C6 alkyl)carbamoyl group, an N,N′-di(C1-C6 alkyl)carbamoyl group, a pentafluorosulfanyl group, a triazolyl group that may be substituted with a C1-C6 alkyl group, an oxadiazolyl group that may be substituted with a C1-C6 alkyl group, a tetrazolyl group that may be substituted with a C1-C6 alkyl group, a (tetrazolyl that may be substituted with a C1-C6 haloalkyl group)C1-C6 alkyl group, a benzoyl group that may be substituted with a halogen atom, an arylsulfonyl group that may be substituted with a halogen atom, an arylsulfinyl group that may be substituted with a halogen atom, an arylthio group that may be substituted with a halogen atom, an arylamino group that may be substituted with a halogen atom, an aryloxy group that may be substituted with a halogen atom, or an aryl group that may be substituted with a halogen atom, more preferably a hydrogen atom, a halogen atom, a cyano group, a hydroxyl group, a carboxyl group, a C1-C6 alkyl group that may be substituted with a hydroxyl group or a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a (C1-C6 alkoxy)C1-C6 fluoroalkyl group, a C1-C6 alkoxy group, a (C1-C6 alkoxy)C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkoxy group, a C1-C6 alkylcarbonyl group, a C1-C6 haloalkylsulfonyloxy group, a C1-C6 alkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 haloalkylthio group, a (C1-C6 alkoxy)carbonyl group, an N—(C1-C6 alkyl)carbamoyl group, a pentafluorosulfanyl group, a triazolyl group that may be substituted with a C1-C6 alkyl group, an oxadiazolyl group that may be substituted with a C1-C6 alkyl group, a tetrazolyl group that may be substituted with a C1-C6 alkyl group, a (tetrazolyl that may be substituted with a C1-C6 haloalkyl group)C1-C6 alkyl group, a benzoyl group that may be substituted with a halogen atom, an arylsulfonyl group that may be substituted with a halogen atom, an arylsulfinyl group that may be substituted with a halogen atom, an arylthio group that may be substituted with a halogen atom, an arylamino group that may be substituted with a halogen atom, an aryloxy group that may be substituted with a halogen atom, or an aryl group that may be substituted with a halogen atom, still more preferably a hydrogen atom, a halogen atom, a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkoxy group, a C1-C6 haloalkylsulfonyloxy group, a C1-C6 haloalkylthio group, a (C1-C6 alkoxy)carbonyl group, a pentafluorosulfanyl group, a triazolyl group that may be substituted with a C1-C6 alkyl group, an oxadiazolyl group that may be substituted with a C1-C6 alkyl group, a tetrazolyl group that may be substituted with a C1-C6 alkyl group, or an aryl group that may be substituted with a halogen atom. 
     Q in formula (1) is preferably a phenyl group or a pyridyl group, each of which may be substituted with one or more groups selected from the group of substituents above, more preferably a phenyl group or a pyridyl group, each of which may be substituted with one or more groups selected from the group consisting of a halogen atom, a cyano group, a nitro group, a carboxyl group, a C1-C6 alkyl group that may be substituted with a hydroxyl group or a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkyl group {substituted with an N-carbamoyl group (that may be substituted with a C1-C6 alkyl group)}, a C1-C6 haloalkyl group {substituted with an N-arylcarbamoyl group (that may be substituted with a halogen atom or a C1-C6 alkyl group)}, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkoxycarbonyl group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, a C1-C6 haloalkylcarbonyl group, a pentafluorosulfanyl group, an N-(phenyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, a (C1-C6 alkyl)aminosulfonyl group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, a phenoxy group that may be substituted with a halogen atom or a C1-C6 alkyl group, and a benzoyl group that may be substituted with a halogen atom. 
     The phenyl group that may be substituted with one or more groups selected from the group of substituents above is preferably a phenyl group that may be substituted with one or more groups selected from the group consisting of a halogen atom, a cyano group, a carboxyl group, a C1-C6 alkyl group that may be substituted with a hydroxyl group or a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkyl group {substituted with an N-carbamoyl group (that may be substituted with a C1-C6 alkyl group)}, a C1-C6 haloalkyl group {substituted with an N-arylcarbamoyl group (that may be substituted with a halogen atom or a C1-C6 alkyl group)}, a C1-C6 haloalkoxy group, a C1-C6 alkoxycarbonyl group, a C1-C6 alkylcarbonyl group, a pentafluorosulfanyl group, an N-(phenyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, a phenyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, a phenoxy group that may be substituted with a halogen atom or a C1-C6 alkyl group, and a benzoyl group that may be substituted with a halogen atom, more preferably a phenyl group that may be substituted with one or more groups selected from the group consisting of a halogen atom, a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkoxy group, a C1-C6 alkoxycarbonyl group, and a pentafluorosulfanyl group. 
     The pyridyl group that may be substituted with one or more groups selected from the group of substituents above is preferably a pyridyl group that may be substituted with one or more groups selected from the group consisting of a halogen atom, a cyano group, a C1-C6 alkyl group that may be substituted with a cyano group, a C3-C6 cycloalkyl group that may be substituted with a cyano group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group that may be substituted with a cyano group, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 alkylcarbonyl group, a C1-C6 haloalkylcarbonyl group, and a pentafluorosulfanyl group, more preferably a pyridyl group that may be substituted with one or more groups selected from the group consisting of a halogen atom, a cyano group, a C1-C6 alkoxy group, and a C1-C6 haloalkyl group that may be substituted with a cyano group, and most preferably a pyridyl group that may be substituted with one or more groups selected from the group consisting of a halogen atom, a cyano group, and a C1-C6 haloalkyl group that may be substituted with a cyano group. 
     Z in formula (1) is preferably a hydrogen atom, a halogen atom, a cyano group, an amino group, a carboxyl group, a carbamoyl group, a C1-C6 alkyl group, a C3-C6 cycloalkyl group, a (C1-C6 alkoxy)C1-C6 alkyl group, a C1-C6 haloalkyl group, a C1-C6 alkoxycarbonyl group, an N—(C1-C6 alkyl)carbamoyl group, an N-(phenyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N,N′-di(C1-C6 alkyl)carbamoyl group, a (C1-C6 haloalkyl)carbonylamino group, an N,N′-di(C1-C6 alkyl)carbonylamino group, or an arylcarbonylamino group that may be substituted with a halogen atom or a C1-C6 alkyl group, more preferably a hydrogen atom, a halogen atom, a cyano group, an amino group, a carboxyl group, a carbamoyl group, a C1-C6 alkyl group, a (C1-C6 alkoxy)C1-C6 alkyl group, a C1-C6 alkoxycarbonyl group, an N—(C1-C6 alkyl)carbamoyl group, an N-(phenyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N,N′-di(C1-C6 alkyl)carbamoyl group, a (C1-C6 haloalkyl)carbonylamino group, an N,N′-di(C1-C6 alkyl)carbonylamino group, or an arylcarbonylamino group that may be substituted with a halogen atom or a C1-C6 alkyl group, still more preferably a hydrogen atom, a halogen atom, a cyano group, an amino group, a C1-C6 alkyl group, a C1-C6 alkoxycarbonyl group, or an N,N′-di(C1-C6 alkyl)carbamoyl group, yet still more preferably a hydrogen atom, a halogen atom, a cyano group, an amino group, or a C1-C6 alkyl group. 
     Incidentally, in one preferred embodiment of the present application, the 1,2,3-triazole derivative represented by formula (1) is a 1,2,3-triazole derivative represented by the following formula (1A): 
     
       
         
         
             
             
         
       
     
     In formula (1A): 
     R′ represents a C1-C6 alkyl group or a C1-C6 haloalkyl group; n represents an integer of 0 to 2; 
     X′ represents a hydrogen atom, a halogen atom, a cyano group, a nitro group, an amino group, a C1-C6 alkyl group, a C3-C6 cycloalkyl group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, a C1-C6 alkylamino group, a (C1-C6 alkoxy)carbonyl group, a di(C1-C6 alkyl)amino group, a (C1-C6 alkyl)carbonylamino group, a (C1-C6 alkyl)carbonyl(C1-C6 alkyl)amino group, an N—(C1-C6 alkyl)carbamoyl group, or an N,N-di(C1-C6 alkyl)carbamoyl group; 
     m represents an integer of 1 to 4 and when m represents an integer of 2 or more, respective X may be the same or different; 
     Q′ represents a phenyl group or a pyridyl group, each of which may be substituted with one or more groups selected from the group consisting of a hydrogen atom, a halogen atom, a cyano group, a nitro group, a C1-C6 alkyl group, a C3-C6 cycloalkyl group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group, a C1-C6 haloalkoxy group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkoxycarbonyl group, a C1-C6 alkylsulfinyl group, a C1-C6 alkylsulfonyl group, an N—(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 haloalkyl)carbamoyl group, an N-(phenyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N-(pyridyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N,N-di(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 alkylcarbonyl)amino group, an N—(C1-C6 haloalkylcarbonyl)amino group, an N—(C1-C6 alkoxycarbonyl)amino group, an N—(C1-C6 haloalkoxycarbonyl)amino group, a C1-C6 alkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a C1-C6 haloalkylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenylsulfonylamino group in which the nitrogen atom may be substituted with a C1-C6 alkyl group and the phenyl group may be substituted with a halogen atom or a C1-C6 alkyl group, a (C1-C6 alkyl)aminosulfonyl group in which the nitrogen atom may be substituted with a C1-C6 alkyl group, a phenyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, and a phenoxy group that may be substituted with a halogen atom or a C1-C6 alkyl group; 
     Z′ represents a hydrogen atom, a halogen atom, a cyano group, a C1-C6 alkyl group, a C3-C6 cycloalkyl group, a C1-C6 alkoxy group, a C1-C6 haloalkyl group, a C1-C6 alkylthio group, a C1-C6 haloalkylthio group, a C1-C6 alkoxycarbonyl group, an N—(C1-C6 alkyl)carbamoyl group, an N—(C1-C6 haloalkyl)carbamoyl group, an N-(phenyl)carbamoyl group that may be substituted with a halogen atom or a C1-C6 alkyl group, an N,N-di(C1-C6 alkyl)carbamoyl group, an amino group, a C1-C6 alkylamino group, a di(C1-C6 alkyl)amino group, a (C1-C6 alkyl)carbonylamino group, or a (C1-C6 haloalkyl)carbonylamino group. 
     Examples of each group of R′ include those of the corresponding group described for R in formula (1). 
     Examples of each group of X′ include those of the corresponding group described for X in formula (1). 
     Examples of each group of Q′ include those of the corresponding group described for Q in formula (1). 
     Examples of each group of Z′ include those of the corresponding group described for Z in formula (1). 
     Representative examples of the 1,2,3-triazole derivative represented by formula (1) are shown together in Tables 1 to 4 below, but the present invention is not limited to these compounds. These compounds include compounds encompassing an optical isomer, an E form, and a Z form. 
     Each of the following notations in the Tables as well as in the present description represents the corresponding group described below. 
     In addition, “Me” stands for a methyl group, “Et” stands for an ethyl group, “n-Pr” stands for a normal-propyl group, “i-Pr” stands for an isopropyl group, “c-Pr” stands for a cyclopropyl group, “n-Bu” stands for a normal-butyl group, “n-Pen” stands for a normal-pentyl group, “tert-Bu” stands for a tertiary-butyl group, “n-Pen” stands for a normal-pentyl group, “n-Hex” stands for a normal-hexyl group, “Ac” stands for an acetyl group, and “Ph” stands for a phenyl group. 
     
       
         
           
               
             
               
                 TABLE 1-1 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 Com- 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 pound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Point 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 (° C.) 
               
               
                   
               
               
                 1-1  
                 Me 
                 0 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-2  
                 Me 
                 0 
                 H 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-3  
                 Me 
                 0 
                 H 
                 3-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-4  
                 Me 
                 0 
                 H 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-5  
                 Me 
                 0 
                 H 
                 4-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-6  
                 Me 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-7  
                 Me 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-8  
                 Me 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 F 
                 CH 
                 CH 
                   
                   
               
               
                 1-9  
                 Me 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-10 
                 Me 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-11 
                 Me 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-12 
                 Me 
                 0 
                 3-Cl 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-13 
                 Me 
                 0 
                 6-Cl 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-14 
                 Me 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-15 
                 Me 
                 0 
                 5-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-16 
                 Et 
                 0 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                 pale yellow 
                 88-90 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 1-17 
                 Et 
                 0 
                 H 
                 H 
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-18 
                 Et 
                 0 
                 H 
                 H 
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-19 
                 Et 
                 0 
                 H 
                 H 
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-20 
                 Et 
                 0 
                 H 
                 H 
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-21 
                 Et 
                 0 
                 H 
                 3-Cl 
                 H 
                 CH 
                 CH 
                 red-tan oily 
                   
               
               
                 1-22 
                 Et 
                 0 
                 H 
                 4-Cl 
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 1-23 
                 Et 
                 0 
                 H 
                 3-Br 
                 H 
                 CH 
                 CH 
                 red-tan oily 
                   
               
               
                 1-24 
                 Et 
                 0 
                 H 
                 3-OCF 3   
                 H 
                 CH 
                 CH 
                 red-tan oily 
                   
               
               
                 1-25 
                 Et 
                 0 
                 H 
                 2-CF 3   
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 1-26 
                 Et 
                 0 
                 H 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                 tan oily 
                   
               
               
                 1-27 
                 Et 
                 0 
                 H 
                 3-CF 3   
                 Me 
                 CH 
                 CH 
                 red-tan oily 
                   
               
               
                 1-28 
                 Et 
                 0 
                 H 
                 3-CF 3   
                 Et 
                 CH 
                 CH 
                 red-tan oily 
                   
               
               
                 1-29 
                 Et 
                 0 
                 H 
                 3-CF 3   
                 Cl 
                 CH 
                 CH 
                 yellow solid 
                 87-90 
               
               
                 1-30 
                 Et 
                 0 
                 H 
                 3-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-31 
                 Et 
                 0 
                 H 
                 3-CF 3   
                 I 
                 CH 
                 CH 
                 white solid 
                 136-139 
               
               
                 1-32 
                 Et 
                 0 
                 3-Cl 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-33 
                 Et 
                 0 
                 4-Cl 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-34 
                 Et 
                 0 
                 5-Cl 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-35 
                 Et 
                 0 
                 6-Cl 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-36 
                 Et 
                 0 
                 3-CF 3   
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-37 
                 Et 
                 0 
                 4-CF 3   
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-38 
                 Et 
                 0 
                 5-CF 3   
                 3-CF 3   
                 H 
                 CH 
                 CH 
                 yellow oily 
                   
               
               
                 1-39 
                 Et 
                 0 
                 6-CF 3   
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-40 
                 Et 
                 0 
                 H 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 114-115 
               
               
                 1-41 
                 Et 
                 0 
                 H 
                 4-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-42 
                 Et 
                 0 
                 H 
                 4-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-43 
                 Et 
                 0 
                 H 
                 4-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-44 
                 Et 
                 0 
                 H 
                 4-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-45 
                 Et 
                 0 
                 3-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1-2 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting Point 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 (° C.) 
               
               
                   
               
             
            
               
                 1-46 
                 Et 
                 0 
                 4-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-47 
                 Et 
                 0 
                 5-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-48 
                 Et 
                 0 
                 6-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-49 
                 Et 
                 0 
                 3-CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-50 
                 Et 
                 0 
                 4-CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-51 
                 Et 
                 0 
                 5-CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-52 
                 Et 
                 0 
                 6-CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-53 
                 Et 
                 0 
                 H 
                 4-tert-Bu 
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 1-54 
                 Et 
                 0 
                 H 
                 4-Ph 
                 H 
                 CH 
                 CH 
                 brown solid 
                 117-121 
               
               
                 1-55 
                 Et 
                 0 
                 H 
                 4-OPh 
                 H 
                 CH 
                 CH 
                 tan oily 
                   
               
               
                 1-56 
                 Et 
                 0 
                 H 
                 4-CN 
                 H 
                 CH 
                 CH 
                 yellow solid 
                  72-76 
               
               
                 1-57 
                 Et 
                 0 
                 H 
                 2-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 &lt;60 
               
               
                 1-58 
                 Et 
                 0 
                 H 
                 2-Cl-4-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-59 
                 Et 
                 0 
                 H 
                 2-Cl-4-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-60 
                 Et 
                 0 
                 H 
                 2-Cl-4-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-61 
                 Et 
                 0 
                 H 
                 2-Cl-4-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-62 
                 Et 
                 0 
                 H 
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-63 
                 Et 
                 0 
                 H 
                 3-Me-5-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-64 
                 Et 
                 0 
                 H 
                 3-Me-5-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-65 
                 Et 
                 0 
                 H 
                 3-Me-5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-66 
                 Et 
                 0 
                 H 
                 3-Me-5-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-67 
                 Et 
                 0 
                 3-Cl 
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-68 
                 Et 
                 0 
                 4-Cl 
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-69 
                 Et 
                 0 
                 5-Cl 
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-70 
                 Et 
                 0 
                 6-Cl 
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-71 
                 Et 
                 0 
                 3-CF 3   
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-72 
                 Et 
                 0 
                 4-CF 3   
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-73 
                 Et 
                 0 
                 5-CF 3   
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-74 
                 Et 
                 0 
                 6-CF 3   
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-75 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 yellow solid 
                 67 
               
               
                 1-76 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-77 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 c-Pr 
                 CH 
                 CH 
                   
                   
               
               
                 1-78 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 CF 3   
                 CH 
                 CH 
                   
                   
               
               
                 1-79 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-80 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-81 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                 white solid 
                 122-125 
               
               
                 1-82 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 NH 2   
                 CH 
                 CH 
                 red-tan oily 
                   
               
               
                 1-83 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 CO 2 Et 
                 CH 
                 CH 
                 yellow oily 
                   
               
               
                 1-84 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 CN 
                 CH 
                 CH 
                 yellow solid 
                 119-121 
               
               
                 1-85 
                 Et 
                 0 
                 3-Cl 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 118-120 
               
               
                 1-86 
                 Et 
                 0 
                 4-Cl 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 115-118 
               
               
                 1-87 
                 Et 
                 0 
                 5-Cl 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                  98-100 
               
               
                 1-88 
                 Et 
                 0 
                 6-Cl 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 yellow solid 
                 119-124 
               
               
                 1-89 
                 Et 
                 0 
                 3-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-90 
                 Et 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 yellow solid 
                 125-127 
               
               
                 1-91 
                 Et 
                 0 
                 5-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 colorless oily 
                  98-100 
               
               
                 1-92 
                 Et 
                 0 
                 6-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-93 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-94 
                 Et 
                 0 
                 3-Cl 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-95 
                 Et 
                 0 
                 4-Cl 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-96 
                 Et 
                 0 
                 5-Cl 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-97 
                 Et 
                 0 
                 6-Cl 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-98 
                 Et 
                 0 
                 3-CF 3   
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-99 
                 Et 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-100 
                 Et 
                 0 
                 5-CF 3   
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1-3 
               
               
                   
               
               
                 Com- 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting  
               
               
                 pound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Point 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 (° C.) 
               
               
                   
               
             
            
               
                 1-101 
                 Et 
                 0 
                 6-CF 3   
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-102 
                 Et 
                 0 
                 3-Cl 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-103 
                 Et 
                 0 
                 4-Cl 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-104 
                 Et 
                 0 
                 5-Cl 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-105 
                 Et 
                 0 
                 6-Cl 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-106 
                 Et 
                 0 
                 3-CF 3   
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-107 
                 Et 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-108 
                 Et 
                 0 
                 5-CF 3   
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-109 
                 Et 
                 0 
                 6-CF 3   
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-110 
                 Et 
                 0 
                 3-Cl 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-111 
                 Et 
                 0 
                 4-Cl 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-112 
                 Et 
                 0 
                 5-Cl 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-113 
                 Et 
                 0 
                 6-Cl 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-114 
                 Et 
                 0 
                 3-CF 3   
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-115 
                 Et 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-116 
                 Et 
                 0 
                 5-CF 3   
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-117 
                 Et 
                 0 
                 6-CF 3   
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-118 
                 Et 
                 0 
                 3-Cl 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-119 
                 Et 
                 0 
                 4-Cl 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-120 
                 Et 
                 0 
                 5-Cl 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-121 
                 Et 
                 0 
                 6-Cl 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-122 
                 Et 
                 0 
                 3-CF 3   
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-123 
                 Et 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-124 
                 Et 
                 0 
                 5-CF 3   
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-125 
                 Et 
                 0 
                 6-CF 3   
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-126 
                 Et 
                 0 
                 H 
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-127 
                 Et 
                 0 
                 H 
                 4-Cl-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-128 
                 Et 
                 0 
                 H 
                 4-Cl-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-129 
                 Et 
                 0 
                 H 
                 4-Cl-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-130 
                 Et 
                 0 
                 H 
                 4-Cl-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-131 
                 Et 
                 0 
                 3-Cl 
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-132 
                 Et 
                 0 
                 4-Cl 
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-133 
                 Et 
                 0 
                 5-Cl 
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-134 
                 Et 
                 0 
                 6-Cl 
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-135 
                 Et 
                 0 
                 3-CF 3   
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-136 
                 Et 
                 0 
                 4-CF 3   
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-137 
                 Et 
                 0 
                 5-CF 3   
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-138 
                 Et 
                 0 
                 6-CF 3   
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-139 
                 Et 
                 0 
                 3-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-140 
                 Et 
                 0 
                 4-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-141 
                 Et 
                 0 
                 5-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-142 
                 Et 
                 0 
                 6-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-143 
                 Et 
                 0 
                 3-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-144 
                 Et 
                 0 
                 4-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-145 
                 Et 
                 0 
                 5-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-146 
                 Et 
                 0 
                 6-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-147 
                 Et 
                 0 
                 3-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-148 
                 Et 
                 0 
                 4-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-149 
                 Et 
                 0 
                 5-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-150 
                 Et 
                 0 
                 6-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-151 
                 Et 
                 0 
                 3-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-152 
                 Et 
                 0 
                 4-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-153 
                 Et 
                 0 
                 5-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-154 
                 Et 
                 0 
                 6-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-155 
                 Et 
                 0 
                 3-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1-4 
               
               
                   
               
               
                 Com- 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting  
               
               
                 pound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Point 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 (° C.) 
               
               
                   
               
             
            
               
                 1-156 
                 Et 
                 0 
                 4-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-157 
                 Et 
                 0 
                 5-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-158 
                 Et 
                 0 
                 6-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-159 
                 Et 
                 0 
                 3-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-160 
                 Et 
                 0 
                 4-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-161 
                 Et 
                 0 
                 5-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-162 
                 Et 
                 0 
                 6-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-163 
                 Et 
                 0 
                 3-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-164 
                 Et 
                 0 
                 4-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-165 
                 Et 
                 0 
                 5-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-166 
                 Et 
                 0 
                 6-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-167 
                 Et 
                 0 
                 3-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-168 
                 Et 
                 0 
                 4-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-169 
                 Et 
                 0 
                 5-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-170 
                 Et 
                 0 
                 6-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-171 
                 Et 
                 0 
                 H 
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-172 
                 Et 
                 0 
                 H 
                 3-F-5-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-173 
                 Et 
                 0 
                 H 
                 3-F-5-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-174 
                 Et 
                 0 
                 H 
                 3-F-5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-175 
                 Et 
                 0 
                 H 
                 3-F-5-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-176 
                 Et 
                 0 
                 3-Cl 
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-177 
                 Et 
                 0 
                 4-Cl 
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-178 
                 Et 
                 0 
                 5-Cl 
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-179 
                 Et 
                 0 
                 6-Cl 
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-180 
                 Et 
                 0 
                 3-CF 3   
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-181 
                 Et 
                 0 
                 4-CF 3   
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-182 
                 Et 
                 0 
                 5-CF 3   
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-183 
                 Et 
                 0 
                 6-CF 3   
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-184 
                 Et 
                 0 
                 H 
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-185 
                 Et 
                 0 
                 H 
                 3-Cl-5-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-186 
                 Et 
                 0 
                 H 
                 3-Cl-5-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-187 
                 Et 
                 0 
                 H 
                 3-Cl-5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-188 
                 Et 
                 0 
                 H 
                 3-Cl-5-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-189 
                 Et 
                 0 
                 3-Cl 
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-190 
                 Et 
                 0 
                 4-Cl 
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-191 
                 Et 
                 0 
                 5-Cl 
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-192 
                 Et 
                 0 
                 6-Cl 
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-193 
                 Et 
                 0 
                 3-CF 3   
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-194 
                 Et 
                 0 
                 4-CF 3   
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-195 
                 Et 
                 0 
                 5-CF 3   
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-196 
                 Et 
                 0 
                 6-CF 3   
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-197 
                 Et 
                 0 
                 H 
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                 colorless  
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 oily 
                   
               
               
                 1-198 
                 Et 
                 0 
                 H 
                 3-Br-5-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-199 
                 Et 
                 0 
                 H 
                 3-Br-5-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-200 
                 Et 
                 0 
                 H 
                 3-Br-5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-201 
                 Et 
                 0 
                 H 
                 3-Br-5-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-202 
                 Et 
                 0 
                 3-Cl 
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-203 
                 Et 
                 0 
                 4-Cl 
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-204 
                 Et 
                 0 
                 5-Cl 
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-205 
                 Et 
                 0 
                 6-Cl 
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-206 
                 Et 
                 0 
                 3-CF 3   
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-207 
                 Et 
                 0 
                 4-CF 3   
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-208 
                 Et 
                 0 
                 5-CF 3   
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-209 
                 Et 
                 0 
                 6-CF 3   
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-210 
                 Et 
                 0 
                 H 
                 3-CO 2 Me-5-CF 3   
                 H 
                 CH 
                 CH 
                 yellow  
                 97-100 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1-5 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
             
            
               
                 1-211 
                 Et 
                 0 
                 H 
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-212 
                 Et 
                 0 
                 4-Cl 
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-213 
                 Et 
                 0 
                 5-Cl 
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-214 
                 Et 
                 0 
                 6-Cl 
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-215 
                 Et 
                 0 
                 3-CF 3   
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-216 
                 Et 
                 0 
                 4-CF 3   
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-217 
                 Et 
                 0 
                 5-CF 3   
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-218 
                 Et 
                 0 
                 6-CF 3   
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-219 
                 Et 
                 0 
                 H 
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-220 
                 Et 
                 0 
                 4-Cl 
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-221 
                 Et 
                 0 
                 5-Cl 
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-222 
                 Et 
                 0 
                 6-Cl 
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-223 
                 Et 
                 0 
                 3-CF 3   
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-224 
                 Et 
                 0 
                 4-CF 3   
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-225 
                 Et 
                 0 
                 5-CF 3   
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-226 
                 Et 
                 0 
                 6-CF 3   
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-227 
                 Et 
                 0 
                 H 
                 3-CONHPh-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 89-96 
               
               
                 1-228 
                 Et 
                 0 
                 H 
                 3-CONH(4-ClC 6 H 4 )-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                  93-106 
               
               
                 1-229 
                 Et 
                 0 
                 5-F 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 yellow solid 
                 72-77 
               
               
                 1-230 
                 Et 
                 0 
                 5-Me 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 orange solid 
                 98-99 
               
               
                 1-231 
                 Et 
                 0 
                 5-OMe 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 orange oily 
                   
               
               
                 1-232 
                 Et 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 N 
                 CH 
                 white solid 
                 136-138 
               
               
                 1-233 
                 Et 
                 0 
                 H 
                 4-CF(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 pale yellow solid 
                 134-138 
               
               
                 1-234 
                 Et 
                 0 
                 H 
                 3-CF 2 CONH 2 -5-CF 3   
                 H 
                 CH 
                 CH 
                 yellow solid 
                 82-84 
               
               
                 1-235 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 F 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 1-236 
                 Et 
                 0 
                 H 
                 3-SF 5   
                 H 
                 CH 
                 CH 
                 white solid 
                 62-63 
               
               
                 1-237 
                 Et 
                 0 
                 H 
                 3-Ac-5-CF 3   
                 H 
                 CH 
                 CH 
                 yellow oily 
                   
               
               
                 1-238 
                 Et 
                 0 
                 H 
                 3-CF 3 -5- 
                 H 
                 CH 
                 CH 
                 yellow oily 
                   
               
               
                   
                   
                   
                   
                 CF 2 CONHMe 
                   
                   
                   
                   
                   
               
               
                 1-239 
                 Et 
                 0 
                 H 
                 3,5-Cl 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 113-114 
               
               
                 1-240 
                 Et 
                 0 
                 H 
                 3-CF 2 CN-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 66-68 
               
               
                 1-241 
                 Et 
                 0 
                 H 
                 3-COPh-5-CF 3   
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 1-242 
                 Et 
                 0 
                 H 
                 3-CF 3 -5- 
                 H 
                 CH 
                 CH 
                 white solid 
                 125-127 
               
               
                   
                   
                   
                   
                 CF 2 CONHPh 
                   
                   
                   
                   
                   
               
               
                 1-243 
                 Et 
                 0 
                 H 
                 3-CF 2 Me-5-CF 3   
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 1-244 
                 CHFCH 3   
                 0 
                 H 
                 3-CF 2 Me-5-CF 3   
                 H 
                 CH 
                 CH 
                 pale yellow oily 
                   
               
               
                 1-245 
                 Et 
                 0 
                 H 
                 3-Ph-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 130-131 
               
               
                 1-246 
                 Et 
                 0 
                 H 
                 3-(c-Pr)-5-CF 3   
                 H 
                 CH 
                 CH 
                 orange oily 
                   
               
               
                 1-247 
                 Et 
                 0 
                 4-Ph 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 92-93 
               
               
                 1-248 
                 Et 
                 0 
                 4-(4-ClC 6 H 4 ) 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 170-171 
               
               
                 1-249 
                 Et 
                 0 
                 4-OPh 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 1-250 
                 Et 
                 0 
                 4-CN 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 yellow solid 
                 187-188 
               
               
                 1-251 
                 Et 
                 0 
                 4-Br 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 125-126 
               
               
                   
               
               
                 1-252 
                 Et 
                 0 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 brown solid 
                 205-206 
               
               
                   
               
               
                 1-253 
                 Et 
                 0 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                   
               
               
                 1-254 
                 Et 
                 0 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 162-164 
               
               
                 1-255 
                 Et 
                 0 
                 4-(c-Pr) 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 110-112 
               
               
                 1-256 
                 Et 
                 0 
                 H 
                 3-CH 2 CN-5-CF 3   
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 1-257 
                 Et 
                 0 
                 4-COOH 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 pale yellow solid 
                 248-250 
               
               
                 1-258 
                 Et 
                 0 
                 4-CH 2 OH 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 yellow solid 
                 122-126 
               
               
                 1-259 
                 Et 
                 0 
                 H 
                 3-(1- 
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                   
                   
                   
                   
                 cyanocyclopropyl)-5-CF 3   
                   
                   
                   
                   
                   
               
               
                   
               
               
                 1-260 
                 Et 
                 0 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1-6 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
             
            
               
                 1-261 
                 Et 
                 0 
                 4-NHPh 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 1-262 
                 Et 
                 0 
                 4-SOPh 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-263 
                 Et 
                 0 
                 4-SPh 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-264 
                 Et 
                 0 
                 4-SO 2 Ph 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-265 
                 Et 
                 0 
                 4-COOEt 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                 156-159 
               
               
                 1-266 
                 Et 
                 0 
                 4-CONHMe 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 209-211 
               
               
                 1-267 
                 Et 
                 0 
                 4-CH 2 CN 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 146-149 
               
               
                   
               
               
                 1-268 
                 Et 
                 0 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 orange solid 
                 130-133 
               
               
                   
               
               
                 1-269 
                 Et 
                 0 
                 6-COOEt 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 114-117 
               
               
                 1-270 
                 Et 
                 0 
                 6-CONHMe 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 218-219 
               
               
                 1-271 
                 Et 
                 0 
                 4-Cl-6-SEt 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 yellow solid 
                 169-171 
               
               
                 1-272 
                 Et 
                 0 
                 4-Cl-6-SO 2 Et 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-273 
                 Et 
                 0 
                 4-Ac 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 163-165 
               
               
                 1-274 
                 Et 
                 0 
                 4-COPh 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 147-150 
               
               
                 1-275 
                 Et 
                 0 
                 H 
                 2-F-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 60&gt; 
               
               
                   
               
               
                 1-276 
                 Et 
                 0 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                   
               
               
                 1-277 
                 Et 
                 0 
                 4-I 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 orange solid 
                 113-118 
               
               
                 1-278 
                 Et 
                 0 
                 4-OCF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 91-94 
               
               
                 1-279 
                 Et 
                 0 
                 4-CF 3   
                 4-CF 3   
                 H 
                 N 
                 CH 
                 white solid 
                 101-103 
               
               
                 1-280 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 COOH 
                 CH 
                 CH 
                 white solid 
                 158-161 
               
               
                 1-281 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 CONH 2   
                 CH 
                 CH 
                 white solid 
                 227-232 
               
               
                 1-282 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 CONHPh 
                 CH 
                 CH 
                 white solid 
                 173-175 
               
               
                 1-283 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 CONH(4- 
                 CH 
                 CH 
                 white solid 
                 207-209 
               
               
                   
                   
                   
                   
                   
                 ClC 6 H 4 ) 
                   
                   
                   
                   
               
               
                 1-284 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 CONHMe 
                 CH 
                 CH 
                 white solid 
                 136-139 
               
               
                 1-285 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 CONMe 2   
                 CH 
                 CH 
                 yellow oily 
                   
               
               
                 1-286 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 NHCOCF 3   
                 CH 
                 CH 
                 white solid 
                 166-169 
               
               
                 1-287 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 NHCOPh 
                 CH 
                 CH 
                 orange solid 
                 160-164 
               
               
                 1-288 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 NHCO(3- 
                 CH 
                 CH 
                 orange solid 
                 138-140 
               
               
                   
                   
                   
                   
                   
                 ClC 6 H 4 ) 
                   
                   
                   
                   
               
               
                 1-289 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 NHCO(4- 
                 CH 
                 CH 
                 white solid 
                 204-208 
               
               
                   
                   
                   
                   
                   
                 ClC 6 H 4 ) 
                   
                   
                   
                   
               
               
                 1-290 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 NAc 2   
                 CH 
                 CH 
                 pale yellow oily 
                   
               
               
                 1-291 
                 Et 
                 0 
                 H 
                 3-COOH-5- 
                 H 
                 CH 
                 CH 
                 pale yellow solid 
                 208-209 
               
               
                   
                   
                   
                   
                 CF 3   
                   
                   
                   
                   
                   
               
               
                 1-292 
                 Et 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 NHCO(2- 
                 CH 
                 CH 
                 orange solid 
                 155-158 
               
               
                   
                   
                   
                   
                   
                 ClC 6 H 4 ) 
                   
                   
                   
                   
               
               
                 1-293 
                 Et 
                 0 
                 4-CF(CF 3 ) 2   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-294 
                 Et 
                 0 
                 4-SF 5   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-295 
                 Et 
                 1 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                 white solid 
                 161-165 
               
               
                 1-296 
                 Et 
                 1 
                 H 
                 H 
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-297 
                 Et 
                 1 
                 H 
                 H 
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-298 
                 Et 
                 1 
                 H 
                 H 
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-299 
                 Et 
                 1 
                 H 
                 H 
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-300 
                 Et 
                 1 
                 H 
                 3-Cl 
                 H 
                 CH 
                 CH 
                 white solid 
                 134-136 
               
               
                 1-301 
                 Et 
                 1 
                 H 
                 4-Cl 
                 H 
                 CH 
                 CH 
                 white solid 
                 180-181 
               
               
                 1-302 
                 Et 
                 1 
                 H 
                 3-Br 
                 H 
                 CH 
                 CH 
                 white solid 
                 141-144 
               
               
                 1-303 
                 Et 
                 1 
                 H 
                 3-OCF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 109-112 
               
               
                 1-304 
                 Et 
                 1 
                 H 
                 2-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 131-133 
               
               
                 1-305 
                 Et 
                 1 
                 H 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 144-147 
               
               
                 1-306 
                 Et 
                 1 
                 H 
                 3-CF 3   
                 Me 
                 CH 
                 CH 
                 red-tan oily 
                   
               
               
                 1-307 
                 Et 
                 1 
                 H 
                 3-CF 3   
                 Et 
                 CH 
                 CH 
                   
                   
               
               
                 1-308 
                 Et 
                 1 
                 H 
                 3-CF 3   
                 Cl 
                 CH 
                 CH 
                 pale yellow oily 
                   
               
               
                 1-309 
                 Et 
                 1 
                 H 
                 3-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-310 
                 Et 
                 1 
                 H 
                 3-CF 3   
                 I 
                 CH 
                 CH 
                 white solid 
                 122-125 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1-7 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting Point 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 (° C.) 
               
               
                   
               
             
            
               
                 1-311 
                 Et 
                 1 
                 3-Cl 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-312 
                 Et 
                 1 
                 4-Cl 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-313 
                 Et 
                 1 
                 5-Cl 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-314 
                 Et 
                 1 
                 6-Cl 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-315 
                 Et 
                 1 
                 3-CF 3   
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-316 
                 Et 
                 1 
                 4-CF 3   
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-317 
                 Et 
                 1 
                 5-CF 3   
                 3-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 140-145 
               
               
                 1-318 
                 Et 
                 1 
                 6-CF 3   
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-319 
                 Et 
                 1 
                 H 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 149-152 
               
               
                 1-320 
                 Et 
                 1 
                 H 
                 4-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-321 
                 Et 
                 1 
                 H 
                 4-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-322 
                 Et 
                 1 
                 H 
                 4-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-323 
                 Et 
                 1 
                 H 
                 4-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-324 
                 Et 
                 1 
                 3-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-325 
                 Et 
                 1 
                 4-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-326 
                 Et 
                 1 
                 5-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-327 
                 Et 
                 1 
                 6-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-328 
                 Et 
                 1 
                 3-CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-329 
                 Et 
                 1 
                 4-CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-330 
                 Et 
                 1 
                 5-CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-331 
                 Et 
                 1 
                 6-CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-332 
                 Et 
                 1 
                 H 
                 4-tert-Bu 
                 H 
                 CH 
                 CH 
                 white solid 
                 162-167 
               
               
                 1-333 
                 Et 
                 1 
                 H 
                 4-Ph 
                 H 
                 CH 
                 CH 
                 yellow solid 
                 157-160 
               
               
                 1-334 
                 Et 
                 1 
                 H 
                 4-OPh 
                 H 
                 CH 
                 CH 
                 tan oily 
                   
               
               
                 1-335 
                 Et 
                 1 
                 H 
                 4-CN 
                 H 
                 CH 
                 CH 
                 white solid 
                 158-160 
               
               
                 1-336 
                 Et 
                 1 
                 H 
                 2-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 103-105 
               
               
                 1-337 
                 Et 
                 1 
                 H 
                 2-Cl-4-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-338 
                 Et 
                 1 
                 H 
                 2-Cl-4-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-339 
                 Et 
                 1 
                 H 
                 2-Cl-4-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-340 
                 Et 
                 1 
                 H 
                 2-Cl-4-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-341 
                 Et 
                 1 
                 H 
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-342 
                 Et 
                 1 
                 H 
                 3-Me-5-CF 3    
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-343 
                 Et 
                 1 
                 H 
                 3-Me-5-CF 3    
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-344 
                 Et 
                 1 
                 H 
                 3-Me-5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-345 
                 Et 
                 1 
                 H 
                 3-Me-5-CF 3    
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-346 
                 Et 
                 1 
                 3-Cl 
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-347 
                 Et 
                 1 
                 4-Cl 
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-348 
                 Et 
                 1 
                 5-Cl 
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-349 
                 Et 
                 1 
                 6-Cl 
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-350 
                 Et 
                 1 
                 3-CF 3   
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-351 
                 Et 
                 1 
                 4-CF 3   
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-352 
                 Et 
                 1 
                 5-CF 3   
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-353 
                 Et 
                 1 
                 6-CF 3   
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-354 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 yellow solid 
                 169-171 
               
               
                 1-355 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-356 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 c-Pr 
                 CH 
                 CH 
                   
                   
               
               
                 1-357 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 CF3 
                 CH 
                 CH 
                   
                   
               
               
                 1-358 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-359 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-360 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                 white solid 
                 148-152 
               
               
                 1-361 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 NH 2   
                 CH 
                 CH 
                 white solid 
                 84-89 
               
               
                 1-362 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 CO 2 Et  
                 CH 
                 CH 
                 pale yellow oily 
                   
               
               
                 1-363 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 CN 
                 CH 
                 CH 
                 white solid 
                 134-137 
               
               
                 1-364 
                 Et 
                 1 
                 3-Cl 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                 79-82 
               
               
                 1-365 
                 Et 
                 1 
                 4-Cl 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                 186-187 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1-8 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting Point 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 (° C.) 
               
               
                   
               
             
            
               
                 1-366 
                 Et 
                 1 
                 5-Cl 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 pale yellow solid 
                 78-82 
               
               
                 1-367 
                 Et 
                 1 
                 6-Cl 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                 64-68 
               
               
                 1-368 
                 Et 
                 1 
                 3-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-369 
                 Et 
                 1 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 136-137 
               
               
                 1-370 
                 Et 
                 1 
                 5-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 66-81 
               
               
                 1-371 
                 Et 
                 1 
                 6-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-372 
                 Et 
                 1 
                 3-Cl 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-373 
                 Et 
                 1 
                 4-Cl 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-374 
                 Et 
                 1 
                 5-Cl 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-375 
                 Et 
                 1 
                 6-Cl 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-376 
                 Et 
                 1 
                 3-CF 3   
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-377 
                 Et 
                 1 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-378 
                 Et 
                 1 
                 5-CF 3   
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-379 
                 Et 
                 1 
                 6-CF 3   
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-380 
                 Et 
                 1 
                 3-Cl 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-381 
                 Et 
                 1 
                 4-Cl 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-382 
                 Et 
                 1 
                 5-Cl 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-383 
                 Et 
                 1 
                 6-Cl 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-384 
                 Et 
                 1 
                 3-CF 3   
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-385 
                 Et 
                 1 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-386 
                 Et 
                 1 
                 5-CF 3   
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-387 
                 Et 
                 1 
                 6-CF 3   
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-388 
                 Et 
                 1 
                 3-Cl 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-389 
                 Et 
                 1 
                 4-Cl 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-390 
                 Et 
                 1 
                 5-Cl 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-391 
                 Et 
                 1 
                 6-Cl 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-392 
                 Et 
                 1 
                 3-CF 3   
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-393 
                 Et 
                 1 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-394 
                 Et 
                 1 
                 5-CF 3   
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-395 
                 Et 
                 1 
                 6-CF 3   
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-396 
                 Et 
                 1 
                 3-Cl 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-397 
                 Et 
                 1 
                 4-Cl 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-398 
                 Et 
                 1 
                 5-Cl 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-399 
                 Et 
                 1 
                 6-Cl 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-400 
                 Et 
                 1 
                 3-CF 3   
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-401 
                 Et 
                 1 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-402 
                 Et 
                 1 
                 5-CF 3   
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-403 
                 Et 
                 1 
                 6-CF 3   
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-404 
                 Et 
                 1 
                 H 
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-405 
                 Et 
                 1 
                 H 
                 4-Cl-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-406 
                 Et 
                 1 
                 H 
                 4-Cl-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-407 
                 Et 
                 1 
                 H 
                 4-Cl-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-408 
                 Et 
                 1 
                 H 
                 4-Cl-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-409 
                 Et 
                 1 
                 3-Cl 
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-410 
                 Et 
                 1 
                 4-Cl 
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-411 
                 Et 
                 1 
                 5-Cl 
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-412 
                 Et 
                 1 
                 6-Cl 
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-413 
                 Et 
                 1 
                 3-CF 3   
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-414 
                 Et 
                 1 
                 4-CF 3   
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-415 
                 Et 
                 1 
                 5-CF 3   
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-416 
                 Et 
                 1 
                 6-CF 3   
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-417 
                 Et 
                 1 
                 3-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-418 
                 Et 
                 1 
                 4-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-419 
                 Et 
                 1 
                 5-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-420 
                 Et 
                 1 
                 6-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1-9 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
             
            
               
                 1-421 
                 Et 
                 1 
                 3-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-422 
                 Et 
                 1 
                 4-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-423 
                 Et 
                 1 
                 5-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-424 
                 Et 
                 1 
                 6-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-425 
                 Et 
                 1 
                 3-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-426 
                 Et 
                 1 
                 4-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-427 
                 Et 
                 1 
                 5-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-428 
                 Et 
                 1 
                 6-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-429 
                 Et 
                 1 
                 3-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-430 
                 Et 
                 1 
                 4-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-431 
                 Et 
                 1 
                 5-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-432 
                 Et 
                 1 
                 6-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-433 
                 Et 
                 1 
                 3-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-434 
                 Et 
                 1 
                 4-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-435 
                 Et 
                 1 
                 5-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-436 
                 Et 
                 1 
                 6-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-437 
                 Et 
                 1 
                 3-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-438 
                 Et 
                 1 
                 4-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-439 
                 Et 
                 1 
                 5-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-440 
                 Et 
                 1 
                 6-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-441 
                 Et 
                 1 
                 3-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-442 
                 Et 
                 1 
                 4-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-443 
                 Et 
                 1 
                 5-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-444 
                 Et 
                 1 
                 6-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-445 
                 Et 
                 1 
                 3-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-446 
                 Et 
                 1 
                 4-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-447 
                 Et 
                 1 
                 5-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-448 
                 Et 
                 1 
                 6-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-449 
                 Et 
                 1 
                 H 
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-450 
                 Et 
                 1 
                 H 
                 3-F-5-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-451 
                 Et 
                 1 
                 H 
                 3-F-5-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-452 
                 Et 
                 1 
                 H 
                 3-F-5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-453 
                 Et 
                 1 
                 H 
                 3-F-5-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-454 
                 Et 
                 1 
                 3-Cl 
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-455 
                 Et 
                 1 
                 4-Cl 
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-456 
                 Et 
                 1 
                 5-Cl 
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-457 
                 Et 
                 1 
                 6-Cl 
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-458 
                 Et 
                 1 
                 3-CF 3   
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-459 
                 Et 
                 1 
                 4-CF 3   
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-460 
                 Et 
                 1 
                 5-CF 3   
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-461 
                 Et 
                 1 
                 6-CF 3   
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-462 
                 Et 
                 1 
                 H 
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-463 
                 Et 
                 1 
                 H 
                 3-Cl-5-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-464 
                 Et 
                 1 
                 H 
                 3-Cl-5-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-465 
                 Et 
                 1 
                 H 
                 3-Cl-5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-466 
                 Et 
                 1 
                 H 
                 3-Cl-5-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-467 
                 Et 
                 1 
                 3-Cl 
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-468 
                 Et 
                 1 
                 4-Cl 
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-469 
                 Et 
                 1 
                 5-Cl 
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-470 
                 Et 
                 1 
                 6-Cl 
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-471 
                 Et 
                 1 
                 3-CF 3   
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-472 
                 Et 
                 1 
                 4-CF 3   
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-473 
                 Et 
                 1 
                 5-CF 3   
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-474 
                 Et 
                 1 
                 6-CF 3   
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-475 
                 Et 
                 1 
                 H 
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 172-173 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1-10 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
             
            
               
                 1-476 
                 Et 
                 1 
                 H 
                 3-Br-5-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-477 
                 Et 
                 1 
                 H 
                 3-Br-5-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-478 
                 Et 
                 1 
                 H 
                 3-Br-5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-479 
                 Et 
                 1 
                 H 
                 3-Br-5-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-480 
                 Et 
                 1 
                 3-Cl 
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-481 
                 Et 
                 1 
                 4-Cl 
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-482 
                 Et 
                 1 
                 5-Cl 
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-483 
                 Et 
                 1 
                 6-Cl 
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-484 
                 Et 
                 1 
                 3-CF 3   
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-485 
                 Et 
                 1 
                 4-CF 3   
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-486 
                 Et 
                 1 
                 5-CF 3   
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-487 
                 Et 
                 1 
                 6-CF 3   
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-488 
                 Et 
                 1 
                 H 
                 3-CO 2 Me-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 71-82 
               
               
                 1-489 
                 Et 
                 1 
                 H 
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-490 
                 Et 
                 1 
                 4-Cl 
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-491 
                 Et 
                 1 
                 5-Cl 
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-492 
                 Et 
                 1 
                 6-Cl 
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-493 
                 Et 
                 1 
                 3-CF 3   
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-494 
                 Et 
                 1 
                 4-CF 3   
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-495 
                 Et 
                 1 
                 5-CF 3   
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-496 
                 Et 
                 1 
                 6-CF 3   
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-497 
                 Et 
                 1 
                 H 
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-498 
                 Et 
                 1 
                 4-Cl 
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-499 
                 Et 
                 1 
                 5-Cl 
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-500 
                 Et 
                 1 
                 6-Cl 
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-501 
                 Et 
                 1 
                 3-CF 3   
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-502 
                 Et 
                 1 
                 4-CF 3   
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-503 
                 Et 
                 1 
                 5-CF 3   
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-504 
                 Et 
                 1 
                 6-CF 3   
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-505 
                 Et 
                 1 
                 H 
                 3-CONHPh-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 227-230 
               
               
                 1-506 
                 Et 
                 1 
                 H 
                 3-CONH(4-ClC 6 H 4 )- 
                 H 
                 CH 
                 CH 
                 white solid 
                 206-211 
               
               
                   
                   
                   
                   
                 5-CF 3   
                   
                   
                   
                   
                   
               
               
                 1-507 
                 Et 
                 1 
                 5-F 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 187-188 
               
               
                 1-508 
                 Et 
                 1 
                 5-Me 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 166-167 
               
               
                 1-509 
                 Et 
                 1 
                 5-OMe 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 65-70 
               
               
                 1-510 
                 Et 
                 1 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 N 
                 CH 
                 white solid 
                 250≤ 
               
               
                 1-511 
                 Et 
                 1 
                 H 
                 4-CF(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 174-179 
               
               
                 1-512 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 F 
                 CH 
                 CH 
                 white solid 
                 120-122 
               
               
                 1-513 
                 Et 
                 1 
                 H 
                 3-SF 5   
                 H 
                 CH 
                 CH 
                 white solid 
                 153-154 
               
               
                 1-514 
                 Et 
                 1 
                 H 
                 3-Ac-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 154-156 
               
               
                 1-515 
                 Et 
                 1 
                 H 
                 3-CF 3 -5- 
                 H 
                 CH 
                 CH 
                 white solid 
                 79-83 
               
               
                   
                   
                   
                   
                 CF 2 CONHMe 
                   
                   
                   
                   
                   
               
               
                 1-516 
                 Et 
                 1 
                 H 
                 3,5-Cl 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 196-199 
               
               
                 1-517 
                 Et 
                 1 
                 H 
                 3-CF 2 CN-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 152-155 
               
               
                 1-518 
                 Et 
                 1 
                 H 
                 3-COPh-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 112-122 
               
               
                 1-519 
                 Et 
                 1 
                 H 
                 3-CF 3 -5- 
                 H 
                 CH 
                 CH 
                 white solid 
                 90-97 
               
               
                   
                   
                   
                   
                 CF 2 CONHPh 
                   
                   
                   
                   
                   
               
               
                 1-520 
                 Et 
                 1 
                 H 
                 3-CF 2 Me-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 165-167 
               
               
                 1-521 
                 CHFCH 3   
                 1 
                 H 
                 3-CF 2 Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-522 
                 Et 
                 1 
                 H 
                 3-Ph-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 158-159 
               
               
                 1-523 
                 Et 
                 1 
                 H 
                 3-(c-Pr)-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 159-160 
               
               
                 1-524 
                 Et 
                 1 
                 4-Ph 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 178-179 
               
               
                 1-525 
                 Et 
                 1 
                 4-(4-ClC 6 H 4 ) 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 188-189 
               
               
                 1-526 
                 Et 
                 1 
                 4-OPh 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 142-144 
               
               
                 1-527 
                 Et 
                 1 
                 4-CN 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 203-206 
               
               
                 1-528 
                 Et 
                 1 
                 4-Br 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 187-189 
               
               
                   
               
               
                 1-529 
                 Et 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 250≤ 
               
               
                   
               
               
                 1-530 
                 Et 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1-11 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
             
            
               
                 1-531 
                 Et 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 207-212 
               
               
                   
               
               
                 1-532 
                 Et 
                 1 
                 4-(c-Pr) 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 180-181 
               
               
                 1-533 
                 Et 
                 1 
                 H 
                 3-CH 2 CN-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-534 
                 Et 
                 1 
                 4-COOH 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-535 
                 Et 
                 1 
                 4-CH 2 OH 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-536 
                 Et 
                 1 
                 H 
                 3-(1- 
                 H 
                 CH 
                 CH 
                 white solid 
                 189-191 
               
               
                   
                   
                   
                   
                 cyanocyclopropyl)- 
                   
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 5-CF 3   
                   
                   
                   
                   
                   
               
               
                   
               
               
                 1-537 
                 Et 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 176-178 
               
               
                 1-538 
                 Et 
                 1 
                 4-NHPh 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 163-164 
               
               
                 1-539 
                 Et 
                 1 
                 4-SPh 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-540 
                 Et 
                 1 
                 4-SOPh 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-541 
                 Et 
                 1 
                 4-SO 2 Ph 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-542 
                 Et 
                 1 
                 4-COOEt 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 166-169 
               
               
                 1-543 
                 Et 
                 1 
                 4-CONHMe 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 225-226 
               
               
                 1-544 
                 Et 
                 1 
                 4-CH 2 CN 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                   
               
               
                 1-545 
                 Et 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 201-204 
               
               
                   
               
               
                 1-546 
                 Et 
                 1 
                 6-COOEt 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-547 
                 Et 
                 1 
                 6-CONHMe 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 101-112 
               
               
                 1-548 
                 Et 
                 1 
                 4-Cl-6-SEt 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-549 
                 Et 
                 1 
                 4-Cl-6-SO 2 Et 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-550 
                 Et 
                 1 
                 4-Ac 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 163-165 
               
               
                 1-551 
                 Et 
                 1 
                 4-COPh 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 201-203 
               
               
                 1-552 
                 Et 
                 1 
                 H 
                 2-F-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 145-146 
               
               
                   
               
               
                 1-553 
                 Et 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-554 
                 Et 
                 1 
                 4-I 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 173-176 
               
               
                 1-555 
                 Et 
                 1 
                 4-OCF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 131-132 
               
               
                 1-556 
                 Et 
                 1 
                 4-CF 3   
                 4-CF 3   
                 H 
                 N 
                 CH 
                 white solid 
                 196-198 
               
               
                 1-557 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 COOH 
                 CH 
                 CH 
                   
                   
               
               
                 1-558 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 CONH 2   
                 CH 
                 CH 
                   
                   
               
               
                 1-559 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 CONHPh 
                 CH 
                 CH 
                 white solid 
                 184-186 
               
               
                 1-560 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 CONH(4- 
                 CH 
                 CH 
                 white solid 
                 102-106 
               
               
                   
                   
                   
                   
                   
                 ClC 6 H 4 ) 
                   
                   
                   
                   
               
               
                 1-561 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 CONHMe 
                 CH 
                 CH 
                 white solid 
                 209-211 
               
               
                 1-562 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 CONMe 2   
                 CH 
                 CH 
                 white solid 
                 140-142 
               
               
                 1-563 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 NHCOCF 3   
                 CH 
                 CH 
                 pale yellow 
                 97-99 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 1-564 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 NHCOPh 
                 CH 
                 CH 
                 white solid 
                 103-108 
               
               
                 1-565 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 NHCO(3- 
                 CH 
                 CH 
                 white solid 
                  96-103 
               
               
                   
                   
                   
                   
                   
                 ClC 6 H 4 ) 
                   
                   
                   
                   
               
               
                 1-566 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 NHCO(4- 
                 CH 
                 CH 
                 white solid 
                 104-112 
               
               
                   
                   
                   
                   
                   
                 ClC 6 H 4 ) 
                   
                   
                   
                   
               
               
                 1-567 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 NAc 2   
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 1-568 
                 Et 
                 1 
                 H 
                 3-COOH-5- 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                   
                   
                   
                   
                 CF 3   
                   
                   
                   
                   
                   
               
               
                 1-569 
                 Et 
                 1 
                 H 
                 3,5-(CF 3 ) 2   
                 NHCO(2- 
                 CH 
                 CH 
                 white solid 
                 173-177 
               
               
                   
                   
                   
                   
                   
                 ClC 6 H 4 ) 
                   
                   
                   
                   
               
               
                 1-570 
                 Et 
                 1 
                 4-CF(CF 3 ) 2   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-571 
                 Et 
                 1 
                 4-SF 5   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-572 
                 Et 
                 2 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                 white solid 
                 156-158 
               
               
                 1-573 
                 Et 
                 2 
                 H 
                 H 
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-574 
                 Et 
                 2 
                 H 
                 H 
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-575 
                 Et 
                 2 
                 H 
                 H 
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-576 
                 Et 
                 2 
                 H 
                 H 
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-577 
                 Et 
                 2 
                 H 
                 3-Cl 
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 1-578 
                 Et 
                 2 
                 H 
                 4-Cl 
                 H 
                 CH 
                 CH 
                 white solid 
                 150-151 
               
               
                 1-579 
                 Et 
                 2 
                 H 
                 3-Br 
                 H 
                 CH 
                 CH 
                 white solid 
                 155-160 
               
               
                 1-580 
                 Et 
                 2 
                 H 
                 3-OCF 3   
                 H 
                 CH 
                 CH 
                 colorless oily 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1-12 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
             
            
               
                 1-581 
                 Et 
                 2 
                 H 
                 2-CF 3   
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 1-582 
                 Et 
                 2 
                 H 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                 yellow solid 
                 105-114 
               
               
                 1-583 
                 Et 
                 2 
                 H 
                 3-CF 3   
                 Me 
                 CH 
                 CH 
                 red-tan oily 
                   
               
               
                 1-584 
                 Et 
                 2 
                 H 
                 3-CF 3   
                 Et 
                 CH 
                 CH 
                 pale yellow oily 
                   
               
               
                 1-585 
                 Et 
                 2 
                 H 
                 3-CF 3   
                 Cl 
                 CH 
                 CH 
                 pale yellow oily 
                   
               
               
                 1-586 
                 Et 
                 2 
                 H 
                 3-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-587 
                 Et 
                 2 
                 H 
                 3-CF 3   
                 I 
                 CH 
                 CH 
                 white solid 
                 163-165 
               
               
                 1-588 
                 Et 
                 2 
                 3-Cl 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-589 
                 Et 
                 2 
                 4-Cl 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-590 
                 Et 
                 2 
                 5-Cl 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-591 
                 Et 
                 2 
                 6-Cl 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-592 
                 Et 
                 2 
                 3-CF 3   
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-593 
                 Et 
                 2 
                 4-CF 3   
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-594 
                 Et 
                 2 
                 5-CF 3   
                 3-CF 3   
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 1-595 
                 Et 
                 2 
                 6-CF 3   
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-596 
                 Et 
                 2 
                 H 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 168-171 
               
               
                 1-597 
                 Et 
                 2 
                 H 
                 4-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-598 
                 Et 
                 2 
                 H 
                 4-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-599 
                 Et 
                 2 
                 H 
                 4-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-600 
                 Et 
                 2 
                 H 
                 4-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-601 
                 Et 
                 2 
                 3-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-602 
                 Et 
                 2 
                 4-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-603 
                 Et 
                 2 
                 5-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-604 
                 Et 
                 2 
                 6-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-605 
                 Et 
                 2 
                 3-CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-606 
                 Et 
                 2 
                 4-CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-607 
                 Et 
                 2 
                 5-CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-608 
                 Et 
                 2 
                 6-CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-609 
                 Et 
                 2 
                 H 
                 4-tert-Bu  
                 H 
                 CH 
                 CH 
                 white solid 
                 127-131 
               
               
                 1-610 
                 Et 
                 2 
                 H 
                 4-Ph 
                 H 
                 CH 
                 CH 
                 yellow solid 
                 178-181 
               
               
                 1-611 
                 Et 
                 2 
                 H 
                 4-OPh 
                 H 
                 CH 
                 CH 
                 tan solid 
                 155-159 
               
               
                 1-612 
                 Et 
                 2 
                 H 
                 4-CN 
                 H 
                 CH 
                 CH 
                 white solid 
                 165-167 
               
               
                 1-613 
                 Et 
                 2 
                 H 
                 2-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 137-139 
               
               
                 1-614 
                 Et 
                 2 
                 H 
                 2-Cl-4-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-615 
                 Et 
                 2 
                 H 
                 2-Cl-4-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-616 
                 Et 
                 2 
                 H 
                 2-Cl-4-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-617 
                 Et 
                 2 
                 H 
                 2-Cl-4-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-618 
                 Et 
                 2 
                 H 
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-619 
                 Et 
                 2 
                 H 
                 3-Me-5-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-620 
                 Et 
                 2 
                 H 
                 3-Me-5-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-621 
                 Et 
                 2 
                 H 
                 3-Me-5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-622 
                 Et 
                 2 
                 H 
                 3-Me-5-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-623 
                 Et 
                 2 
                 3-Cl 
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-624 
                 Et 
                 2 
                 4-Cl 
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-625 
                 Et 
                 2 
                 5-Cl 
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-626 
                 Et 
                 2 
                 6-Cl 
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-627 
                 Et 
                 2 
                 3-CF 3   
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-628 
                 Et 
                 2 
                 4-CF 3   
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-629 
                 Et 
                 2 
                 5-CF 3   
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-630 
                 Et 
                 2 
                 6-CF 3   
                 3-Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-631 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 135-139 
               
               
                 1-632 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-633 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 c-Pr  
                 CH 
                 CH 
                   
                   
               
               
                 1-634 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 CF 3   
                 CH 
                 CH 
                   
                   
               
               
                 1-635 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1-13 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
             
            
               
                 1-636 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-637 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                 white solid 
                 182-185 
               
               
                 1-638 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 NH 2    
                 CH 
                 CH 
                 white solid 
                  83-90 
               
               
                 1-639 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 CO 2 Et 
                 CH 
                 CH 
                 pale yellow  
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 oily 
                   
               
               
                 1-640 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 CN 
                 CH 
                 CH 
                 white solid 
                 135-138 
               
               
                 1-641 
                 Et 
                 2 
                 3-Cl 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 170-172 
               
               
                 1-642 
                 Et 
                 2 
                 4-Cl 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 180-182 
               
               
                 1-643 
                 Et 
                 2 
                 5-Cl 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                  72-75 
               
               
                 1-644 
                 Et 
                 2 
                 6-Cl 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 156-158 
               
               
                 1-645 
                 Et 
                 2 
                 3-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-646 
                 Et 
                 2 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 156-158 
               
               
                 1-647 
                 Et 
                 2 
                 5-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 171-173 
               
               
                 1-648 
                 Et 
                 2 
                 6-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-649 
                 Et 
                 2 
                 3-Cl 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-650 
                 Et 
                 2 
                 4-Cl 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-651 
                 Et 
                 2 
                 5-Cl 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-652 
                 Et 
                 2 
                 6-Cl 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-653 
                 Et 
                 2 
                 3-CF 3   
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-654 
                 Et 
                 2 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-655 
                 Et 
                 2 
                 5-CF 3   
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-656 
                 Et 
                 2 
                 6-CF 3   
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-657 
                 Et 
                 2 
                 3-Cl 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-658 
                 Et 
                 2 
                 4-Cl 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-659 
                 Et 
                 2 
                 5-Cl 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-660 
                 Et 
                 2 
                 6-Cl 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-661 
                 Et 
                 2 
                 3-CF 3   
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-662 
                 Et 
                 2 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-663 
                 Et 
                 2 
                 5-CF 3   
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-664 
                 Et 
                 2 
                 6-CF 3   
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-665 
                 Et 
                 2 
                 3-Cl 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-666 
                 Et 
                 2 
                 4-Cl 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-667 
                 Et 
                 2 
                 5-Cl 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-668 
                 Et 
                 2 
                 6-Cl 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-669 
                 Et 
                 2 
                 3-CF 3   
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-670 
                 Et 
                 2 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-671 
                 Et 
                 2 
                 5-CF 3   
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-672 
                 Et 
                 2 
                 6-CF 3   
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-673 
                 Et 
                 2 
                 3-Cl 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-674 
                 Et 
                 2 
                 4-Cl 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-675 
                 Et 
                 2 
                 5-Cl 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-676 
                 Et 
                 2 
                 6-Cl 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-677 
                 Et 
                 2 
                 3-CF 3   
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-678 
                 Et 
                 2 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-679 
                 Et 
                 2 
                 5-CF 3   
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-680 
                 Et 
                 2 
                 6-CF 3   
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-681 
                 Et 
                 2 
                 H 
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-682 
                 Et 
                 2 
                 H 
                 4-Cl-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-683 
                 Et 
                 2 
                 H 
                 4-Cl-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-684 
                 Et 
                 2 
                 H 
                 4-Cl-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-685 
                 Et 
                 2 
                 H 
                 4-Cl-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-686 
                 Et 
                 2 
                 3-Cl 
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-687 
                 Et 
                 2 
                 4-Cl 
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-688 
                 Et 
                 2 
                 5-Cl 
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-689 
                 Et 
                 2 
                 6-Cl 
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-690 
                 Et 
                 2 
                 3-CF 3   
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1-14 
               
               
                   
               
               
                 Com- 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 pound 
                   
                   
                   
                   
                   
                   
                   
                 Pro- 
                 Point  
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 file 
                 (° C.) 
               
               
                   
               
             
            
               
                 1-691 
                 Et 
                 2 
                 4-CF 3   
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-692 
                 Et 
                 2 
                 5-CF 3   
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-693 
                 Et 
                 2 
                 6-CF 3   
                 4-Cl-3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-694 
                 Et 
                 2 
                 3-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-695 
                 Et 
                 2 
                 4-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-696 
                 Et 
                 2 
                 5-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-697 
                 Et 
                 2 
                 6-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-698 
                 Et 
                 2 
                 3-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-699 
                 Et 
                 2 
                 4-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-700 
                 Et 
                 2 
                 5-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-701 
                 Et 
                 2 
                 6-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-702 
                 Et 
                 2 
                 3-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-703 
                 Et 
                 2 
                 4-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-704 
                 Et 
                 2 
                 5-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-705 
                 Et 
                 2 
                 6-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-706 
                 Et 
                 2 
                 3-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-707 
                 Et 
                 2 
                 4-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-708 
                 Et 
                 2 
                 5-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-709 
                 Et 
                 2 
                 6-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-710 
                 Et 
                 2 
                 3-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-711 
                 Et 
                 2 
                 4-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-712 
                 Et 
                 2 
                 5-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-713 
                 Et 
                 2 
                 6-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-714 
                 Et 
                 2 
                 3-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-715 
                 Et 
                 2 
                 4-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-716 
                 Et 
                 2 
                 5-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-717 
                 Et 
                 2 
                 6-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-718 
                 Et 
                 2 
                 3-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-719 
                 Et 
                 2 
                 4-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-720 
                 Et 
                 2 
                 5-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-721 
                 Et 
                 2 
                 6-Cl 
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-722 
                 Et 
                 2 
                 3-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-723 
                 Et 
                 2 
                 4-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-724 
                 Et 
                 2 
                 5-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-725 
                 Et 
                 2 
                 6-CF 3   
                 4-Me-3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-726 
                 Et 
                 2 
                 H 
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-727 
                 Et 
                 2 
                 H 
                 3-F-5-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-728 
                 Et 
                 2 
                 H 
                 3-F-5-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-729 
                 Et 
                 2 
                 H 
                 3-F-5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-730 
                 Et 
                 2 
                 H 
                 3-F-5-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-731 
                 Et 
                 2 
                 3-Cl 
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-732 
                 Et 
                 2 
                 4-Cl 
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-733 
                 Et 
                 2 
                 5-Cl 
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-734 
                 Et 
                 2 
                 6-Cl 
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-735 
                 Et 
                 2 
                 3-CF 3   
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-736 
                 Et 
                 2 
                 4-CF 3   
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-737 
                 Et 
                 2 
                 5-CF 3   
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-738 
                 Et 
                 2 
                 6-CF 3   
                 3-F-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-739 
                 Et 
                 2 
                 H 
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-740 
                 Et 
                 2 
                 H 
                 3-Cl-5-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-741 
                 Et 
                 2 
                 H 
                 3-Cl-5-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-742 
                 Et 
                 2 
                 H 
                 3-Cl-5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-743 
                 Et 
                 2 
                 H 
                 3-Cl-5-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-744 
                 Et 
                 2 
                 3-Cl 
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-745 
                 Et 
                 2 
                 4-Cl 
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1-15 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
             
            
               
                 1-746 
                 Et 
                 2 
                 5-Cl 
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-747 
                 Et 
                 2 
                 6-Cl 
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-748 
                 Et 
                 2 
                 3-CF 3   
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-749 
                 Et 
                 2 
                 4-CF 3   
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-750 
                 Et 
                 2 
                 5-CF 3   
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-751 
                 Et 
                 2 
                 6-CF 3   
                 3-Cl-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-752 
                 Et 
                 2 
                 H 
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid  
                 161-164 
               
               
                 1-753 
                 Et 
                 2 
                 H 
                 3-Br-5-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-754 
                 Et 
                 2 
                 H 
                 3-Br-5-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-755 
                 Et 
                 2 
                 H 
                 3-Br-5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-756 
                 Et 
                 2 
                 H 
                 3-Br-5-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-757 
                 Et 
                 2 
                 3-Cl 
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-758 
                 Et 
                 2 
                 4-Cl 
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-759 
                 Et 
                 2 
                 5-Cl 
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-760 
                 Et 
                 2 
                 6-Cl 
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-761 
                 Et 
                 2 
                 3-CF 3   
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-762 
                 Et 
                 2 
                 4-CF 3   
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-763 
                 Et 
                 2 
                 5-CF 3   
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-764 
                 Et 
                 2 
                 6-CF 3   
                 3-Br-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-765 
                 Et 
                 2 
                 H 
                 3-CO 2 Me-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid  
                 159-162 
               
               
                 1-766 
                 Et 
                 2 
                 H 
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-767 
                 Et 
                 2 
                 4-Cl 
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-768 
                 Et 
                 2 
                 5-Cl 
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-769 
                 Et 
                 2 
                 6-Cl 
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-770 
                 Et 
                 2 
                 3-CF 3   
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-771 
                 Et 
                 2 
                 4-CF 3   
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-772 
                 Et 
                 2 
                 5-CF 3   
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-773 
                 Et 
                 2 
                 6-CF 3   
                 3,4-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-774 
                 Et 
                 2 
                 H 
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-775 
                 Et 
                 2 
                 4-Cl 
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-776 
                 Et 
                 2 
                 5-Cl 
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-777 
                 Et 
                 2 
                 6-Cl 
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-778 
                 Et 
                 2 
                 3-CF 3   
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-779 
                 Et 
                 2 
                 4-CF 3   
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-780 
                 Et 
                 2 
                 5-CF 3   
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-781 
                 Et 
                 2 
                 6-CF 3   
                 3,4-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-782 
                 Et 
                 2 
                 H 
                 3-CONHPh-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid  
                 232-233 
               
               
                 1-783 
                 Et 
                 2 
                 H 
                 3-CONH(4-ClC 6 H 4 )-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid  
                 200-201 
               
               
                 1-784 
                 Et 
                 2 
                 5-F 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid  
                 132-133 
               
               
                 1-785 
                 Et 
                 2 
                 5-Me 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid  
                 137-140 
               
               
                 1-786 
                 Et 
                 2 
                 5-OMe 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid  
                 146-147 
               
               
                 1-787 
                 Et 
                 2 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 N 
                 CH 
                 white solid  
                 230-233 
               
               
                 1-788 
                 Et 
                 2 
                 H 
                 4-CF(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid  
                 180-182 
               
               
                 1-789 
                 Et 
                 2 
                 H 
                 3-CF 2 CONH 2 -5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-790 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 F 
                 CH 
                 CH 
                 white solid  
                 149-150 
               
               
                 1-791 
                 Et 
                 2 
                 H 
                 3-SF 5    
                 H 
                 CH 
                 CH 
                 white solid  
                 139-142 
               
               
                 1-792 
                 Et 
                 2 
                 H 
                 3-Ac-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid  
                 181-183 
               
               
                 1-793 
                 Et 
                 2 
                 H 
                 3-CF 3 -5-CF 2 CONHMe 
                 H 
                 CH 
                 CH 
                 white solid 
                 &lt;60 
               
               
                 1-794 
                 Et 
                 2 
                 H 
                 3,5-Cl2 
                 H 
                 CH 
                 CH 
                 white solid  
                 179-181 
               
               
                 1-795 
                 Et 
                 2 
                 H 
                 3-CF 2 CN-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid  
                 104-108 
               
               
                 1-796 
                 Et 
                 2 
                 H 
                 3-COPh-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid  
                 201-202 
               
               
                 1-797 
                 Et 
                 2 
                 H 
                 3-CF 2 CONH 2 -5-CF 3   
                 H 
                 CH 
                 CH 
                 thin red solid 
                 174-177 
               
               
                 1-798 
                 Et 
                 2 
                 H 
                 3-CF 2 Me-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid  
                 126-128 
               
               
                 1-799 
                 CHFCH 3   
                 2 
                 H 
                 3-CF 2 Me-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-800 
                 Et 
                 2 
                 H 
                 3-Ph-5-CF 3   
                 H 
                 CH 
                 CH 
                 colorless oily 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1-16 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
             
            
               
                 1-801 
                 Et 
                 2 
                 H 
                 3-(c-Pr)-5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 63-68 
               
               
                 1-802 
                 Et 
                 2 
                 4-Ph 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 225-226 
               
               
                 1-803 
                 Et 
                 2 
                 4-(4-ClC 6 H 4 ) 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 221-222 
               
               
                 1-804 
                 Et 
                 2 
                 4-OPh 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 183-184 
               
               
                 1-805 
                 Et 
                 2 
                 4-CN 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 210-211 
               
               
                 1-806 
                 Et 
                 2 
                 4-Br 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 181-182 
               
               
                   
               
               
                 1-807 
                 Et 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                   
               
               
                 1-808 
                 Et 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 211-213 
               
               
                   
               
               
                 1-809 
                 Et 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 195-197 
               
               
                   
               
               
                 1-810 
                 Et 
                 2 
                 4-(c-Pr) 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 118-120 
               
               
                 1-811 
                 Et 
                 2 
                 H 
                 3-CH 2 CN-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-812 
                 Et 
                 2 
                 4-COOH 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-813 
                 Et 
                 2 
                 4-CH 2 OH 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-814 
                 Et 
                 2 
                 H 
                 3-(1-cyanocyclopropyl)-5-CF 3   
                 H 
                 CH 
                 CH 
                 colorless 
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 oily 
                   
               
               
                   
               
               
                 1-815 
                 Et 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 80-82 
               
               
                   
               
               
                 1-816 
                 Et 
                 2 
                 4-NHPh 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 colorless 
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 oily 
                   
               
               
                 1-817 
                 Et 
                 2 
                 4-SPh 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 179-184 
               
               
                 1-818 
                 Et 
                 2 
                 4-SOPh 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 94-98 
               
               
                 1-819 
                 Et 
                 2 
                 4-SO 2 Ph 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 pale 
                 207-209 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 yellow 
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 1-820 
                 Et 
                 2 
                 4-COOEt 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 162-164 
               
               
                 1-821 
                 Et 
                 2 
                 4-CONHMe 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 ≥250 
               
               
                 1-822 
                 Et 
                 2 
                 4-CH 2 CN 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                   
               
               
                 1-823 
                 Et 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 171-173 
               
               
                   
               
               
                 1-824 
                 Et 
                 2 
                 6-COOEt 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-825 
                 Et 
                 2 
                 6-CONHMe 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 211-214 
               
               
                 1-826 
                 Et 
                 2 
                 4-Cl-6-SEt 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-827 
                 Et 
                 2 
                 4-Cl-6-SO 2 Et 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white 
                 209-212 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 1-828 
                 Et 
                 2 
                 4-Ac 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white 
                 211-212 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 1-829 
                 Et 
                 2 
                 4-COPh 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white 
                 227-230 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 1-830 
                 Et 
                 2 
                 H 
                 2-F-5-CF 3   
                 H 
                 CH 
                 CH 
                 colorless 
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 oily 
                   
               
               
                   
               
               
                 1-831 
                 Et 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 80-83 
               
               
                   
               
               
                 1-832 
                 Et 
                 2 
                 4-I 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white 
                 203-204 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 1-833 
                 Et 
                 2 
                 4-OCF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white 
                 143-144 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 1-834 
                 Et 
                 2 
                 4-CF 3   
                 4-CF 3   
                 H 
                 N 
                 CH 
                 white 
                 213-215 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 1-835 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 COOH 
                 CH 
                 CH 
                   
                   
               
               
                 1-836 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 CONH 2   
                 CH 
                 CH 
                   
                   
               
               
                 1-837 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 CONHPh 
                 CH 
                 CH 
                 white 
                 74-85 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 1-838 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 CONH(4- 
                 CH 
                 CH 
                 white 
                 78-83 
               
               
                   
                   
                   
                   
                   
                 ClC 6 H 4 ) 
                   
                   
                 solid 
                   
               
               
                 1-839 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 CONHMe 
                 CH 
                 CH 
                 white 
                 161-165 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 1-840 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 CONMe 2   
                 CH 
                 CH 
                 colorless 
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 oily 
                   
               
               
                 1-841 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 NHCOCF 3   
                 CH 
                 CH 
                 white 
                 198-200 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 1-842 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 NHCOPh 
                 CH 
                 CH 
                 white 
                 91-97 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 1-843 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 NHCO(3- 
                 CH 
                 CH 
                 white 
                 91-97 
               
               
                   
                   
                   
                   
                   
                 ClC 6 H 4 ) 
                   
                   
                 solid 
                   
               
               
                 1-844 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 NHCO(4- 
                 CH 
                 CH 
                 white 
                  96-102 
               
               
                   
                   
                   
                   
                   
                 ClC 6 H 4 ) 
                   
                   
                 solid 
                   
               
               
                 1-845 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 NAc 2   
                 CH 
                 CH 
                 white 
                 159-162 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1-17 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
             
            
               
                 1-846 
                 Et 
                 2 
                 H 
                 3-COOH-5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-847 
                 Et 
                 2 
                 H 
                 3,5-(CF 3 ) 2   
                 NHCO(2-ClC 6 H 4 )  
                 CH 
                 CH 
                 white solid 
                  88-95 
               
               
                 1-848 
                 Et 
                 2 
                 4-CF(CF 3 ) 2   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-849 
                 Et 
                 2 
                 4-SF 5   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-850 
                 Et 
                 0 
                 H 
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-851 
                 Et 
                 0 
                 4-Cl 
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-852 
                 Et 
                 0 
                 4-Br 
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-853 
                 Et 
                 0 
                 4-I 
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                 yellow oily 
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 product 
                   
               
               
                 1-854 
                 Et 
                 0 
                 4-CF 3   
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-855 
                 Et 
                 0 
                 4-OCF 3   
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                 yellow oily 
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 product 
                   
               
               
                 1-856 
                 Et 
                 0 
                 4-SF 5   
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-857 
                 Et 
                 1 
                 H 
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-858 
                 Et 
                 1 
                 4-Cl 
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-859 
                 Et 
                 1 
                 4-Br 
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-860 
                 Et 
                 1 
                 4-I 
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                 white solid 
                 135-140 
               
               
                 1-861 
                 Et 
                 1 
                 4-CF 3   
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-862 
                 Et 
                 1 
                 4-OCF 3   
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                 white solid 
                 135-140 
               
               
                 1-863 
                 Et 
                 1 
                 4-SF 5   
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-864 
                 Et 
                 2 
                 H 
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-865 
                 Et 
                 2 
                 4-Cl 
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-866 
                 Et 
                 2 
                 4-Br 
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-867 
                 Et 
                 2 
                 4-I 
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                 white solid 
                 183-187 
               
               
                 1-868 
                 Et 
                 2 
                 4-CF 3   
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-869 
                 Et 
                 2 
                 4-OCF 3   
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                 white solid 
                 114-117 
               
               
                 1-870 
                 Et 
                 2 
                 4-SF 5   
                 3-CF 3 -4-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-871 
                 n-Pr 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-872 
                 n-Pr 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-873 
                 n-Pr 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-874 
                 n-Pr 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-875 
                 n-Pr 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-876 
                 n-Pr 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-877 
                 n-Pr 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-878 
                 n-Pr 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-879 
                 n-Pr 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-880 
                 n-Pr 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-881 
                 i-Pr  
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-882 
                 i-Pr  
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-883 
                 i-Pr  
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-884 
                 i-Pr  
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-885 
                 i-Pr  
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-886 
                 i-Pr  
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-887 
                 i-Pr  
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-888 
                 i-Pr  
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-889 
                 i-Pr  
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-890 
                 i-Pr  
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-891 
                 n-Bu 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-892 
                 n-Bu 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-893 
                 n-Bu 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-894 
                 n-Bu 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-895 
                 n-Bu 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-896 
                 n-Bu 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-897 
                 n-Bu 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-898 
                 n-Bu 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-899 
                 n-Bu 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-900 
                 n-Bu 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 1-18 
               
               
                   
               
               
                 Com- 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 pound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Point  
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 (° C.) 
               
               
                   
               
             
            
               
                 1-901 
                 n-Pen 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-902 
                 n-Pen 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-903 
                 n-Pen 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-904 
                 n-Pen 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-905 
                 n-Pen 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-906 
                 n-Pen 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-907 
                 n-Pen 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-908 
                 n-Pen 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-909 
                 n-Pen 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-910 
                 n-Pen 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-911 
                 n-Hex 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-912 
                 n-Hex 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-913 
                 n-Hex 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-914 
                 n-Hex 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-915 
                 n-Hex 
                 0 
                 H 
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 1-916 
                 n-Hex 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 1-917 
                 n-Hex 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 1-918 
                 n-Hex 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 1-919 
                 n-Hex 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 1-920 
                 n-Hex 
                 0 
                 4-CF 3   
                 3,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2-1 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 Com- 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 pound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Point 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 (° C.) 
               
               
                   
               
               
                 2-1  
                 Me 
                 0 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-2  
                 Me 
                 0 
                 H 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-3  
                 Me 
                 0 
                 H 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-4  
                 Me 
                 0 
                 H 
                 6-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-5  
                 Me 
                 0 
                 H 
                 4-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-6  
                 Me 
                 0 
                 H 
                 5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-7  
                 Me 
                 0 
                 H 
                 6-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-8  
                 Me 
                 0 
                 4-CF 3   
                 4-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-9  
                 Me 
                 0 
                 4-CF 3   
                 5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-10 
                 Me 
                 0 
                 4-CF 3   
                 6-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-11 
                 Me 
                 0 
                 H 
                 4-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 2-12 
                 Me 
                 0 
                 H 
                 5-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 2-13 
                 Me 
                 0 
                 H 
                 6-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 2-14 
                 Et 
                 0 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                 yellow 
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 oily 
                   
               
               
                 2-15 
                 Et 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 red-tan 
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 oily 
                   
               
               
                 2-16 
                 Et 
                 0 
                 4-Cl 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-17 
                 Et 
                 0 
                 4-Br 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-18 
                 Et 
                 0 
                 4-I 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-19 
                 Et 
                 0 
                 4-CF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-20 
                 Et 
                 0 
                 4-OCF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 yellow 
                 82-84 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 2-21 
                 Et 
                 0 
                 4-SF 5   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-22 
                 Et 
                 0 
                 5-CF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-23 
                 Et 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 2-24 
                 Et 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 2-25 
                 Et 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-26 
                 Et 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 2-27 
                 Et 
                 0 
                 H 
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-28 
                 Et 
                 0 
                 4-Cl 
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-29 
                 Et 
                 0 
                 4-Br 
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-30 
                 Et 
                 0 
                 4-I 
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 yellow 
                 103-105 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 2-31 
                 Et 
                 0 
                 4-CF 3   
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-32 
                 Et 
                 0 
                 4-OCF 3   
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 yellow 
                 86-87 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 2-33 
                 Et 
                 0 
                 4-SF 5   
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 yellow 
                 84-87 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 2-34 
                 Et 
                 0 
                 H 
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-35 
                 Et 
                 0 
                 4-Cl 
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-36 
                 Et 
                 0 
                 4-Br 
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-37 
                 Et 
                 0 
                 4-I 
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-38 
                 Et 
                 0 
                 4-CF 3   
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-39 
                 Et 
                 0 
                 4-OCF 3   
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-40 
                 Et 
                 0 
                 4-SF 5   
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-41 
                 Et 
                 0 
                 H 
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-42 
                 Et 
                 0 
                 4-Cl 
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-43 
                 Et 
                 0 
                 4-Br 
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-44 
                 Et 
                 0 
                 4-I 
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-45 
                 Et 
                 0 
                 4-CF 3   
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 2-2 
               
               
                   
               
               
                 Com- 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 pound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Point  
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 (° C.) 
               
               
                   
               
             
            
               
                 2-46 
                 Et 
                 0 
                 4-OCF 3   
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-47 
                 Et 
                 0 
                 4-SF 5   
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-48 
                 Et 
                 0 
                 H 
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-49 
                 Et 
                 0 
                 4-Cl 
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-50 
                 Et 
                 0 
                 4-Br 
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-51 
                 Et 
                 0 
                 4-I 
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-52 
                 Et 
                 0 
                 4-CF 3   
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-53 
                 Et 
                 0 
                 4-OCF 3   
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-54 
                 Et 
                 0 
                 4-SF 5   
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-55 
                 Et 
                 0 
                 H 
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-56 
                 Et 
                 0 
                 4-Cl 
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-57 
                 Et 
                 0 
                 4-Br 
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-58 
                 Et 
                 0 
                 4-I 
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-59 
                 Et 
                 0 
                 4-CF 3   
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-60 
                 Et 
                 0 
                 4-OCF 3   
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-61 
                 Et 
                 0 
                 4-SF 5   
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-62 
                 Et 
                 0 
                 H 
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-63 
                 Et 
                 0 
                 4-Cl 
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-64 
                 Et 
                 0 
                 4-Br 
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-65 
                 Et 
                 0 
                 4-I 
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                 white  
                 188-197 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 2-66 
                 Et 
                 0 
                 4-CF 3   
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-67 
                 Et 
                 0 
                 4-OCF 3   
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-68 
                 Et 
                 0 
                 4-SF 5   
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-69 
                 Et 
                 0 
                 H 
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-70 
                 Et 
                 0 
                 4-Cl 
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-71 
                 Et 
                 0 
                 4-Br 
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-72 
                 Et 
                 0 
                 4-I 
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-73 
                 Et 
                 0 
                 4-CF 3   
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-74 
                 Et 
                 0 
                 4-OCF 3   
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-75 
                 Et 
                 0 
                 4-SF 5   
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-76 
                 Et 
                 0 
                 H 
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-77 
                 Et 
                 0 
                 4-Cl 
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-78 
                 Et 
                 0 
                 4-Br 
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-79 
                 Et 
                 0 
                 4-I 
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-80 
                 Et 
                 0 
                 4-CF 3   
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-81 
                 Et 
                 0 
                 4-OCF 3   
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-82 
                 Et 
                 0 
                 4-SF 5   
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-83 
                 Et 
                 0 
                 H 
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-84 
                 Et 
                 0 
                 4-Cl 
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-85 
                 Et 
                 0 
                 4-Br 
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-86 
                 Et 
                 0 
                 4-I 
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-87 
                 Et 
                 0 
                 4-CF 3   
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-88 
                 Et 
                 0 
                 4-OCF 3   
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                 white  
                 163 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 2-89 
                 Et 
                 0 
                 4-SF 5   
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-90 
                 Et 
                 0 
                 H 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                 colorless  
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 oily 
                   
               
               
                 2-91 
                 Et 
                 0 
                 H 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 tan oily 
                   
               
               
                 2-92 
                 Et 
                 0 
                 H 
                 4-CF 3   
                 H 
                 N 
                 CH 
                   
                   
               
               
                 2-93 
                 Et 
                 0 
                 H 
                 4-CF 3   
                 H 
                 CH 
                 N 
                   
                   
               
               
                 2-94 
                 Et 
                 0 
                 H 
                 4-CF 3   
                 H 
                 N 
                 N 
                   
                   
               
               
                 2-95 
                 Et 
                 0 
                 3-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 tan oily 
                   
               
               
                 2-96 
                 Et 
                 0 
                 4-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white  
                 114-116 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 2-97 
                 Et 
                 0 
                 5-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 tan solid 
                 122-123 
               
               
                 2-98 
                 Et 
                 0 
                 6-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 colorless  
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 oily 
                   
               
               
                 2-99 
                 Et 
                 0 
                 4-F 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 brown  
                 102 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 2-100 
                 Et 
                 0 
                 4-Br 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 tan solid 
                  97-98 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 2-3 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
             
            
               
                 2-101 
                 Et 
                 0 
                 4-Br 
                 4-CF 3   
                 H 
                 N 
                 CH 
                   
                   
               
               
                 2-102 
                 Et 
                 0 
                 4-1 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 red solid 
                  99-101 
               
               
                 2-103 
                 Et 
                 0 
                 4-Me 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 78-80 
               
               
                 2-104 
                 Et 
                 0 
                 4-CN 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 red solid 
                 145-147 
               
               
                 2-105 
                 Et 
                 0 
                 4-OH 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-106 
                 Et 
                 0 
                 4-COOEt 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-107 
                 Et 
                 0 
                 4-CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 143-145 
               
               
                 2-108 
                 Et 
                 0 
                 4-CF 3   
                 4-CF 3   
                 H 
                 N 
                 CH 
                   
                   
               
               
                 2-109 
                 Et 
                 0 
                 4-CF(CF 3 ) 2   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 yellow solid 
                 90-92 
               
               
                 2-110 
                 Et 
                 0 
                 4-CH(CF 3 ) 2   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 orange oily 
                   
               
               
                 2-111 
                 Et 
                 0 
                 4-C(CF 3 ) 2 OMe 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 orange solid 
                 88-93 
               
               
                 2-112 
                 Et 
                 0 
                 4-OCF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 100-102 
               
               
                 2-113 
                 Et 
                 0 
                 4-SCF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 yellow solid 
                 73-75 
               
               
                 2-114 
                 Et 
                 0 
                 4-SMe 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-115 
                 Et 
                 0 
                 4-SOMe 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-116 
                 Et 
                 0 
                 4-SO 2 Me 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-117 
                 Et 
                 0 
                 4-OSO 2 CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-118 
                 Et 
                 0 
                 4-SF 5   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 red solid 
                 116-120 
               
               
                 2-119 
                 Et 
                 0 
                 4-OCH 2 OCH 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-120 
                 Et 
                 0 
                 4-I-5-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 pale yellow 
                 112-114 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 2-121 
                 Et 
                 0 
                 3,4-Cl 2   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 tan solid 
                 82-84 
               
               
                 2-122 
                 Et 
                 0 
                 3-Cl-4-Br 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 yellow oily 
                   
               
               
                 2-123 
                 Et 
                 0 
                 4-CH 2 CN 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 169 
               
               
                 2-124 
                 Et 
                 0 
                 4-CF 2 CN 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-125 
                 Et 
                 0 
                 4-CH 2 Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 pale yellow 
                 122-124 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 2-126 
                 Et 
                 0 
                 4-CH 2 OH 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 red-tan oily 
                   
               
               
                 2-127 
                 Et 
                 0 
                 4-(c-Pr) 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 84-87 
               
               
                   
               
               
                 2-128 
                 Et 
                 0 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 128-130 
               
               
                   
               
               
                 2-129 
                 Et 
                 0 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                   
               
               
                 2-130 
                 Et 
                 0 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                   
               
               
                 2-131 
                 Et 
                 0 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 126-127 
               
               
                   
               
               
                 2-132 
                 Et 
                 0 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 110-111 
               
               
                   
               
               
                 2-133 
                 Et 
                 0 
                 H 
                 4-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 2-134 
                 Et 
                 0 
                 4-CF 3   
                 4-CF 3   
                 Me 
                 CH 
                 CH 
                 tan solid 
                 89-98 
               
               
                 2-135 
                 Et 
                 0 
                 4-OCF 3   
                 4-CF 3   
                 Me 
                 CH 
                 CH 
                 tan oily 
                   
               
               
                 2-136 
                 Et 
                 0 
                 4-OCF 3   
                 4-CF 3   
                 CH 2 OMe 
                 CH 
                 CH 
                   
                   
               
               
                 2-137 
                 Et 
                 0 
                 H 
                 4-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 2-138 
                 Et 
                 0 
                 H 
                 4-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-139 
                 Et 
                 0 
                 H 
                 4-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 2-140 
                 Et 
                 0 
                 H 
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                 yellow oily 
                   
               
               
                 2-141 
                 Et 
                 0 
                 4-Cl 
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-142 
                 Et 
                 0 
                 4-Br 
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-143 
                 Et 
                 0 
                 4-I 
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                 red oily 
                   
               
               
                 2-144 
                 Et 
                 0 
                 4-CF 3   
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-145 
                 Et 
                 0 
                 4-OCF 3   
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                 orange solid 
                 113-115 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 2-4 
               
               
                   
               
               
                 Compound  
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
             
            
               
                 2-146 
                 Et 
                 0 
                 4-SF 5   
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-147 
                 Et 
                 0 
                 H 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 103-104 
               
               
                 2-148 
                 Et 
                 0 
                 H 
                 6-CF 3   
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 2-149 
                 Et 
                 0 
                 H 
                 6-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 2-150 
                 Et 
                 0 
                 H 
                 6-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 2-151 
                 Et 
                 0 
                 H 
                 6-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-152 
                 Et 
                 0 
                 H 
                 6-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 2-153 
                 Et 
                 1 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                 white solid  
                 170-172 
               
               
                 2-154 
                 Et 
                 1 
                 H 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-155 
                 Et 
                 1 
                 4-Cl 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-156 
                 Et 
                 1 
                 4-Br 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-157 
                 Et 
                 1 
                 4-I 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-158 
                 Et 
                 1 
                 4-CF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-159 
                 Et 
                 1 
                 4-OCF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-160 
                 Et 
                 1 
                 4-SF 5   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-161 
                 Et 
                 1 
                 5-CF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-162 
                 Et 
                 1 
                 H 
                 4,6-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 2-163 
                 Et 
                 1 
                 H 
                 4,6-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 2-164 
                 Et 
                 1 
                 H 
                 4,6-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-165 
                 Et 
                 1 
                 H 
                 4,6-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 2-166 
                 Et 
                 1 
                 H 
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-167 
                 Et 
                 1 
                 4-Cl 
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-168 
                 Et 
                 1 
                 4-Br 
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-169 
                 Et 
                 1 
                 4-I 
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid  
                 167-170 
               
               
                 2-170 
                 Et 
                 1 
                 4-CF 3   
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-171 
                 Et 
                 1 
                 4-OCF 3   
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid  
                 150-152 
               
               
                 2-172 
                 Et 
                 1 
                 4-SF 5   
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid  
                  79-84 
               
               
                 2-173 
                 Et 
                 1 
                 H 
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-174 
                 Et 
                 1 
                 4-Cl 
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-175 
                 Et 
                 1 
                 4-Br 
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-176 
                 Et 
                 1 
                 4-I 
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-177 
                 Et 
                 1 
                 4-CF 3   
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-178 
                 Et 
                 1 
                 4-OCF 3   
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-179 
                 Et 
                 1 
                 4-SF 5   
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-180 
                 Et 
                 1 
                 H 
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-181 
                 Et 
                 1 
                 4-Cl 
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-182 
                 Et 
                 1 
                 4-Br 
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-183 
                 Et 
                 1 
                 4-I 
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-184 
                 Et 
                 1 
                 4-CF 3   
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-185 
                 Et 
                 1 
                 4-OCF 3   
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-186 
                 Et 
                 1 
                 4-SF 5   
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-187 
                 Et 
                 1 
                 H 
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-188 
                 Et 
                 1 
                 4-Cl 
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-189 
                 Et 
                 1 
                 4-Br 
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-190 
                 Et 
                 1 
                 4-I 
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-191 
                 Et 
                 1 
                 4-CF 3   
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-192 
                 Et 
                 1 
                 4-OCF 3   
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-193 
                 Et 
                 1 
                 4-SF 5   
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-194 
                 Et 
                 1 
                 H 
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-195 
                 Et 
                 1 
                 4-Cl 
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-196 
                 Et 
                 1 
                 4-Br 
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-197 
                 Et 
                 1 
                 4-I 
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-198 
                 Et 
                 1 
                 4-CF 3   
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-199 
                 Et 
                 1 
                 4-OCF 3   
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-200 
                 Et 
                 1 
                 4-SF 5   
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 2-5 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
             
            
               
                 2-201 
                 Et 
                 1 
                 H 
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-202 
                 Et 
                 1 
                 4-Cl 
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-203 
                 Et 
                 1 
                 4-Br 
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-204 
                 Et 
                 1 
                 4-I 
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                 white solid 
                 188-197 
               
               
                 2-205 
                 Et 
                 1 
                 4-CF 3   
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-206 
                 Et 
                 1 
                 4-OCF 3   
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-207 
                 Et 
                 1 
                 4-SF 5   
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-208 
                 Et 
                 1 
                 H 
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-209 
                 Et 
                 1 
                 4-Cl 
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-210 
                 Et 
                 1 
                 4-Br 
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-211 
                 Et 
                 1 
                 4-I 
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-212 
                 Et 
                 1 
                 4-CF 3   
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-213 
                 Et 
                 1 
                 4-OCF 3   
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-214 
                 Et 
                 1 
                 4-SF 5   
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-215 
                 Et 
                 1 
                 H 
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-216 
                 Et 
                 1 
                 4-Cl 
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-217 
                 Et 
                 1 
                 4-Br 
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-218 
                 Et 
                 1 
                 4-I 
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-219 
                 Et 
                 1 
                 4-CF 3   
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-220 
                 Et 
                 1 
                 4-OCF 3   
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-221 
                 Et 
                 1 
                 4-SF 5   
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-222 
                 Et 
                 1 
                 H 
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-223 
                 Et 
                 1 
                 4-Cl 
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-224 
                 Et 
                 1 
                 4-Br 
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-225 
                 Et 
                 1 
                 4-I 
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-226 
                 Et 
                 1 
                 4-CF 3   
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-227 
                 Et 
                 1 
                 4-OCF 3   
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                 white solid 
                 163 
               
               
                 2-228 
                 Et 
                 1 
                 4-SF 5   
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-229 
                 Et 
                 1 
                 H 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 175-177 
               
               
                 2-230 
                 Et 
                 1 
                 H 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 165-166 
               
               
                 2-231 
                 Et 
                 1 
                 H 
                 4-CF 3   
                 H 
                 N 
                 CH 
                   
                   
               
               
                 2-232 
                 Et 
                 1 
                 H 
                 4-CF 3   
                 H 
                 CH 
                 N 
                   
                   
               
               
                 2-233 
                 Et 
                 1 
                 H 
                 4-CF 3   
                 H 
                 N 
                 N 
                   
                   
               
               
                 2-234 
                 Et 
                 1 
                 3-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 2-235 
                 Et 
                 1 
                 4-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 175-177 
               
               
                 2-236 
                 Et 
                 1 
                 5-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 158-162 
               
               
                 2-237 
                 Et 
                 1 
                 6-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 2-238 
                 Et 
                 1 
                 4-F 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 183-185 
               
               
                 2-239 
                 Et 
                 1 
                 4-Br 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 186-193 
               
               
                 2-240 
                 Et 
                 1 
                 4-Br 
                 4-CF 3   
                 H 
                 N 
                 CH 
                   
                   
               
               
                 2-241 
                 Et 
                 1 
                 4-I 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 182-186 
               
               
                 2-242 
                 Et 
                 1 
                 4-Me 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 153-156 
               
               
                 2-243 
                 Et 
                 1 
                 4-CN 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 213-215 
               
               
                 2-244 
                 Et 
                 1 
                 4-OH 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-245 
                 Et 
                 1 
                 4-COOEt 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 162-165 
               
               
                 2-246 
                 Et 
                 1 
                 4-CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 186-187 
               
               
                 2-247 
                 Et 
                 1 
                 4-CF 3   
                 4-CF 3   
                 H 
                 N 
                 CH 
                   
                   
               
               
                 2-248 
                 Et 
                 1 
                 4-CF(CF 3 ) 2   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 190-192 
               
               
                 2-249 
                 Et 
                 1 
                 4-CH(CF 3 ) 2   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 154-156 
               
               
                 2-250 
                 Et 
                 1 
                 4-C(CF 3 ) 2 OMe 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 167-169 
               
               
                 2-251 
                 Et 
                 1 
                 4-OMe 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 134-144 
               
               
                 2-252 
                 Et 
                 1 
                 4-OCF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 161-165 
               
               
                 2-253 
                 Et 
                 1 
                 4-SCF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 166-168 
               
               
                 2-254 
                 Et 
                 1 
                 4-SMe 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-255 
                 Et 
                 1 
                 4-SOMe 
                 4-CF 3   
                 H 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 2-6 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
             
            
               
                 2-256 
                 Et 
                 1 
                 4-SO 2 Me 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-257 
                 Et 
                 1 
                 4-OSO 2 CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-258 
                 Et 
                 1 
                 4-SF 5   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 199-201 
               
               
                 2-259 
                 Et 
                 1 
                 4-OCH 2 OCH 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-260 
                 Et 
                 1 
                 4-I-5-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 208-214 
               
               
                 2-261 
                 Et 
                 1 
                 3,4-Cl 2   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 144-146 
               
               
                 2-262 
                 Et 
                 1 
                 3-Cl-4-Br 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 161-165 
               
               
                 2-263 
                 Et 
                 1 
                 4-CH 2 CN 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 200-204 
               
               
                 2-264 
                 Et 
                 1 
                 4-CF 2 CN 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-265 
                 Et 
                 1 
                 4-CH 2 Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-266 
                 Et 
                 1 
                 4-CH 2 OH 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-267 
                 Et 
                 1 
                 4-(c-Pr) 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 117-121 
               
               
                   
               
               
                 2-268 
                 Et 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 157-159 
               
               
                   
               
               
                 2-269 
                 Et 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                   
               
               
                 2-270 
                 Et 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                   
               
               
                 2-271 
                 Et 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 186-187 
               
               
                   
               
               
                 2-272 
                 Et 
                 1 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 123-126 
               
               
                   
               
               
                 2-273 
                 Et 
                 1 
                 H 
                 4-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 2-274 
                 Et 
                 1 
                 4-CF 3   
                 4-CF 3   
                 Me 
                 CH 
                 CH 
                 tan oily 
                   
               
               
                 2-275 
                 Et 
                 1 
                 4-OCF 3   
                 4-CF 3   
                 Me 
                 CH 
                 CH 
                 pale yellow 
                 96-97 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 2-276 
                 Et 
                 1 
                 4-OCF 3   
                 4-CF 3   
                 CH 2 OMe 
                 CH 
                 CH 
                   
                   
               
               
                 2-277 
                 Et 
                 1 
                 H 
                 4-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 2-278 
                 Et 
                 1 
                 H 
                 4-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-279 
                 Et 
                 1 
                 H 
                 4-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 2-280 
                 Et 
                 1 
                 H 
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-281 
                 Et 
                 1 
                 4-Cl 
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-282 
                 Et 
                 1 
                 4-Br 
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-283 
                 Et 
                 1 
                 4-I 
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 157-162 
               
               
                 2-284 
                 Et 
                 1 
                 4-CF 3   
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-285 
                 Et 
                 1 
                 4-OCF 3   
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 165-167 
               
               
                 2-286 
                 Et 
                 1 
                 4-SF 5   
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-287 
                 Et 
                 1 
                 H 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-288 
                 Et 
                 1 
                 H 
                 6-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 172-175 
               
               
                 2-289 
                 Et 
                 1 
                 H 
                 6-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 2-290 
                 Et 
                 1 
                 H 
                 6-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 2-291 
                 Et 
                 1 
                 H 
                 6-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-292 
                 Et 
                 1 
                 H 
                 6-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 2-293 
                 Et 
                 2 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-294 
                 Et 
                 2 
                 H 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                   
               
               
                 2-295 
                 Et 
                 2 
                 4-Cl 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 2-7 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
             
            
               
                 2-296 
                 Et 
                 2 
                 4-Br 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-297 
                 Et 
                 2 
                 4-I 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 154-155 
               
               
                 2-298 
                 Et 
                 2 
                 4-CF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-299 
                 Et 
                 2 
                 4-OCF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid 
                 179-180 
               
               
                 2-300 
                 Et 
                 2 
                 4-SF 5   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-301 
                 Et 
                 2 
                 5-CF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-302 
                 Et 
                 2 
                 H 
                 4,6-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 2-303 
                 Et 
                 2 
                 H 
                 4,6-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 2-304 
                 Et 
                 2 
                 H 
                 4,6-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-305 
                 Et 
                 2 
                 H 
                 4,6-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 2-306 
                 Et 
                 2 
                 H 
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-307 
                 Et 
                 2 
                 4-Cl 
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-308 
                 Et 
                 2 
                 4-Br 
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-309 
                 Et 
                 2 
                 4-I 
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid  
                 186-188 
               
               
                 2-310 
                 Et 
                 2 
                 4-CF 3   
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-311 
                 Et 
                 2 
                 4-OCF 3   
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid  
                 163-164 
               
               
                 2-312 
                 Et 
                 2 
                 4-SF 5   
                 3-CN-4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                 white solid  
                 208-209 
               
               
                 2-313 
                 Et 
                 2 
                 H 
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-314 
                 Et 
                 2 
                 4-Cl 
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-315 
                 Et 
                 2 
                 4-Br 
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-316 
                 Et 
                 2 
                 4-I 
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-317 
                 Et 
                 2 
                 4-CF 3   
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-318 
                 Et 
                 2 
                 4-OCF 3   
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-319 
                 Et 
                 2 
                 4-SF 5   
                 3-Cl-4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-320 
                 Et 
                 2 
                 H 
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-321 
                 Et 
                 2 
                 4-Cl 
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-322 
                 Et 
                 2 
                 4-Br 
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                 white solid 
                 195-198 
               
               
                 2-323 
                 Et 
                 2 
                 4-I 
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                 white solid  
                 190-194 
               
               
                 2-324 
                 Et 
                 2 
                 4-CF 3   
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-325 
                 Et 
                 2 
                 4-OCF 3   
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                 white solid 
                 149-151 
               
               
                 2-326 
                 Et 
                 2 
                 4-SF 5   
                 4-CF 3 -5-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-327 
                 Et 
                 2 
                 H 
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-328 
                 Et 
                 2 
                 4-Cl 
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-329 
                 Et 
                 2 
                 4-Br 
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                 white solid  
                 179-180 
               
               
                 2-330 
                 Et 
                 2 
                 4-I 
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                 white solid  
                 187-188 
               
               
                 2-331 
                 Et 
                 2 
                 4-CF 3   
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-332 
                 Et 
                 2 
                 4-OCF 3   
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                 white solid  
                 179-180 
               
               
                 2-333 
                 Et 
                 2 
                 4-SF 5   
                 4-CF 3 -6-Cl 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-334 
                 Et 
                 2 
                 H 
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-335 
                 Et 
                 2 
                 4-Cl 
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-336 
                 Et 
                 2 
                 4-Br 
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-337 
                 Et 
                 2 
                 4-I 
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-338 
                 Et 
                 2 
                 4-CF 3   
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-339 
                 Et 
                 2 
                 4-OCF 3   
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-340 
                 Et 
                 2 
                 4-SF 5   
                 4-CF 3 -3-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-341 
                 Et 
                 2 
                 H 
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-342 
                 Et 
                 2 
                 4-Cl 
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-343 
                 Et 
                 2 
                 4-Br 
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-344 
                 Et 
                 2 
                 4-I 
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                 white solid  
                 188-197 
               
               
                 2-345 
                 Et 
                 2 
                 4-CF 3   
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-346 
                 Et 
                 2 
                 4-OCF 3   
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-347 
                 Et 
                 2 
                 4-SF 5   
                 4-CF 3 -5-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-348 
                 Et 
                 2 
                 H 
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-349 
                 Et 
                 2 
                 4-Cl 
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-350 
                 Et 
                 2 
                 4-Br 
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 2-8 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
             
            
               
                 2-351 
                 Et 
                 2 
                 4-I 
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                 white solid 
                 180-181 
               
               
                 2-352 
                 Et 
                 2 
                 4-CF 3   
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-353 
                 Et 
                 2 
                 4-OCF 3   
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                 white solid 
                 182-183 
               
               
                 2-354 
                 Et 
                 2 
                 4-SF 5   
                 4-CF 3 -6-Br 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-355 
                 Et 
                 2 
                 H 
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-356 
                 Et 
                 2 
                 4-Cl 
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-357 
                 Et 
                 2 
                 4-Br 
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                 white solid 
                 112-115 
               
               
                 2-358 
                 Et 
                 2 
                 4-I 
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-359 
                 Et 
                 2 
                 4-CF 3   
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-360 
                 Et 
                 2 
                 4-OCF 3   
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-361 
                 Et 
                 2 
                 4-SF 5   
                 4-CF 3 -6-OMe 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-362 
                 Et 
                 2 
                 H 
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-363 
                 Et 
                 2 
                 4-Cl 
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-364 
                 Et 
                 2 
                 4-Br 
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-365 
                 Et 
                 2 
                 4-I 
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-366 
                 Et 
                 2 
                 4-CF 3   
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-367 
                 Et 
                 2 
                 4-OCF 3   
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                 white solid 
                 163 
               
               
                 2-368 
                 Et 
                 2 
                 4-SF 5   
                 4-CF 3 -6-CN 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-369 
                 Et 
                 2 
                 H 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 2-370 
                 Et 
                 2 
                 H 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 162-165 
               
               
                 2-371 
                 Et 
                 2 
                 H 
                 4-CF 3   
                 H 
                 N 
                 CH 
                   
                   
               
               
                 2-372 
                 Et 
                 2 
                 H 
                 4-CF 3   
                 H 
                 CH 
                 N 
                   
                   
               
               
                 2-373 
                 Et 
                 2 
                 H 
                 4-CF 3   
                 H 
                 N 
                 N 
                   
                   
               
               
                 2-374 
                 Et 
                 2 
                 3-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 175-179 
               
               
                 2-375 
                 Et 
                 2 
                 4-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 166-168 
               
               
                 2-376 
                 Et 
                 2 
                 5-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 115-118 
               
               
                 2-377 
                 Et 
                 2 
                 6-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 2-378 
                 Et 
                 2 
                 4-F 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 160-162 
               
               
                 2-379 
                 Et 
                 2 
                 4-Br 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 157-158 
               
               
                 2-380 
                 Et 
                 2 
                 4-Br 
                 4-CF 3   
                 H 
                 N 
                 CH 
                   
                   
               
               
                 2-381 
                 Et 
                 2 
                 4-I 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 144-147 
               
               
                 2-382 
                 Et 
                 2 
                 4-Me 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 147-148 
               
               
                 2-383 
                 Et 
                 2 
                 4-CN 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 193-196 
               
               
                 2-384 
                 Et 
                 2 
                 4-0H 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 128-133 
               
               
                 2-385 
                 Et 
                 2 
                 4-COOEt 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 153-156 
               
               
                 2-386 
                 Et 
                 2 
                 4-CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 168-170 
               
               
                 2-387 
                 Et 
                 2 
                 4-CF 3   
                 4-CF 3   
                 H 
                 N 
                 CH 
                 white solid 
                 145-149 
               
               
                 2-388 
                 Et 
                 2 
                 4-CF(CF 3 ) 2   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 2-389 
                 Et 
                 2 
                 4-CH(CF 3 ) 2   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 145-147 
               
               
                 2-390 
                 Et 
                 2 
                 4-C(CF 3 ) 2 OMe 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 169-171 
               
               
                 2-391 
                 Et 
                 2 
                 4-OMe 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 108-115 
               
               
                 2-392 
                 Et 
                 2 
                 4-OCF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 126-129 
               
               
                 2-393 
                 Et 
                 2 
                 4-SCF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 124-126 
               
               
                 2-394 
                 Et 
                 2 
                 4-SMe 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 125-126 
               
               
                 2-395 
                 Et 
                 2 
                 4-SOMe 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 178-180 
               
               
                 2-396 
                 Et 
                 2 
                 4-SO 2 Me 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 147-151 
               
               
                 2-397 
                 Et 
                 2 
                 4-OSO 2 CF 3   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 120-124 
               
               
                 2-398 
                 Et 
                 2 
                 4-SF 5   
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 173-175 
               
               
                 2-399 
                 Et 
                 2 
                 4-OCH 2 OCH3 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 99-101 
               
               
                 2-400 
                 Et 
                 2 
                 4-I-5-Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 200-202 
               
               
                 2-401 
                 Et 
                 2 
                 3,4-Cl2 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 212-214 
               
               
                 2-402 
                 Et 
                 2 
                 3-Cl-4-Br 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 203-207 
               
               
                 2-403 
                 Et 
                 2 
                 4-CH 2 CN 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 103-106 
               
               
                 2-404 
                 Et 
                 2 
                 4-CF 2 CN 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 tan oily 
                   
               
               
                 2-405 
                 Et 
                 2 
                 4-CH 2 Cl 
                 4-CF 3   
                 H 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 2-9 
               
               
                   
               
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
             
            
               
                 2-406 
                 Et 
                 2 
                 4-CH 2 OH 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-407 
                 Et 
                 2 
                 4-(c-Pr) 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 61-64 
               
               
                   
               
               
                 2-408 
                 Et 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 118-121 
               
               
                   
               
               
                 2-409 
                 Et 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 176-177 
               
               
                   
               
               
                 2-410 
                 Et 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 pale yellow solid 
                 190-191 
               
               
                   
               
               
                 2-411 
                 Et 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 171-174 
               
               
                   
               
               
                 2-412 
                 Et 
                 2 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 128-130 
               
               
                   
               
               
                 2-413 
                 Et 
                 2 
                 H 
                 4-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 2-414 
                 Et 
                 2 
                 4-CF 3   
                 4-CF 3   
                 Me 
                 CH 
                 CH 
                 yellow solid 
                 118-123 
               
               
                 2-415 
                 Et 
                 2 
                 4-OCF 3   
                 4-CF 3   
                 Me 
                 CH 
                 CH 
                 white solid 
                 127-130 
               
               
                 2-416 
                 Et 
                 2 
                 4-OCF 3   
                 4-CF 3   
                 CH 2 OMe 
                 CH 
                 CH 
                 pale yellow 
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 oily 
                   
               
               
                 2-417 
                 Et 
                 2 
                 H 
                 4-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 2-418 
                 Et 
                 2 
                 H 
                 4-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-419 
                 Et 
                 2 
                 H 
                 4-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 2-420 
                 Et 
                 2 
                 H 
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 111-115 
               
               
                 2-421 
                 Et 
                 2 
                 4-Cl 
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-422 
                 Et 
                 2 
                 4-Br 
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-423 
                 Et 
                 2 
                 4-I 
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 71-76 
               
               
                 2-424 
                 Et 
                 2 
                 4-CF 3   
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-425 
                 Et 
                 2 
                 4-OCF 3   
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 144-146 
               
               
                 2-426 
                 Et 
                 2 
                 4-SF 5   
                 4-CF 2 CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-427 
                 Et 
                 2 
                 H 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                 colorless oily 
                   
               
               
                 2-428 
                 Et 
                 2 
                 H 
                 6-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 141-143 
               
               
                 2-429 
                 Et 
                 2 
                 H 
                 6-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 2-430 
                 Et 
                 2 
                 H 
                 6-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 2-431 
                 Et 
                 2 
                 H 
                 6-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-432 
                 Et 
                 2 
                 H 
                 6-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 2-433 
                 n-Pr 
                 0 
                 H 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 66-67 
               
               
                 2-434 
                 n-Pr 
                 0 
                 H 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                 pale yellow 
                 93-95 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 2-435 
                 n-Pr 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-436 
                 n-Pr 
                 0 
                 4-Cl 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-437 
                 n-Pr 
                 0 
                 4-Br 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-438 
                 n-Pr 
                 0 
                 4-CF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-439 
                 n-Pr 
                 0 
                 5-CF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-440 
                 n-Pr 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 2-441 
                 n-Pr 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 2-442 
                 n-Pr 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-443 
                 n-Pr 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 2-444 
                 n-Pr 
                 1 
                 H 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 193-194 
               
               
                 2-445 
                 n-Pr 
                 1 
                 H 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 179-180 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 2-10 
               
               
                   
               
               
                 Com- 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 pound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Point  
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 (° C.) 
               
               
                   
               
             
            
               
                 2-446 
                 n-Pr 
                 2 
                 H 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                 white  
                 120-123 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 2-447 
                 n-Pr 
                 2 
                 H 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                 white  
                 109-111 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 2-448 
                 i-Pr 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-449 
                 i-Pr 
                 0 
                 4-Cl 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-450 
                 i-Pr 
                 0 
                 4-Br 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-451 
                 i-Pr 
                 0 
                 4-CF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-452 
                 i-Pr 
                 0 
                 5-CF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-453 
                 i-Pr 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 2-454 
                 i-Pr 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 2-455 
                 i-Pr 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-456 
                 i-Pr 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 2-457 
                 n-Bu 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-458 
                 n-Bu 
                 0 
                 4-Cl 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-459 
                 n-Bu 
                 0 
                 4-Br 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-460 
                 n-Bu 
                 0 
                 4-CF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-461 
                 n-Bu 
                 0 
                 5-CF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-462 
                 n-Bu 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 2-463 
                 n-Bu 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 2-464 
                 n-Bu 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-465 
                 n-Bu 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 2-466 
                 n-Pen 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-467 
                 n-Pen 
                 0 
                 4-Cl 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-468 
                 n-Pen 
                 0 
                 4-Br 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-469 
                 n-Pen 
                 0 
                 4-CF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-470 
                 n-Pen 
                 0 
                 5-CF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-471 
                 n-Pen 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 2-472 
                 n-Pen 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 2-473 
                 n-Pen 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-474 
                 n-Pen 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 2-475 
                 n-Hex 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-476 
                 n-Hex 
                 0 
                 4-Cl 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-477 
                 n-Hex 
                 0 
                 4-Br 
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-478 
                 n-Hex 
                 0 
                 4-CF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-479 
                 n-Hex 
                 0 
                 5-CF 3   
                 4,6-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 2-480 
                 n-Hex 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 2-481 
                 n-Hex 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 2-482 
                 n-Hex 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 2-483 
                 n-Hex 
                 0 
                 H 
                 4,6-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 2-484 
                 CF 3 CH 2   
                 0 
                 H 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                 yellow  
                   
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 oily 
                   
               
               
                 2-485 
                 CF 3 CH 2   
                 1 
                 H 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                 white  
                 198-199 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 solid 
                   
               
               
                 2-486 
                 CF 3 CH 2   
                 2 
                 H 
                 5-CF 3   
                 H 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 3-1 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 Compound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
               
                 3-1  
                 Me 
                 0 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-2  
                 Me 
                 0 
                 H 
                 4-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-3  
                 Me 
                 0 
                 H 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-4  
                 Me 
                 0 
                 H 
                 6-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-5  
                 Me 
                 0 
                 H 
                 4-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 3-6  
                 Me 
                 0 
                 H 
                 5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 3-7  
                 Me 
                 0 
                 H 
                 6-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 3-8  
                 Me 
                 0 
                 4-CF 3   
                 4-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 3-9  
                 Me 
                 0 
                 4-CF 3   
                 5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 3-10 
                 Me 
                 0 
                 4-CF 3   
                 6-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 3-11 
                 Me 
                 0 
                 H 
                 4-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 3-12 
                 Me 
                 0 
                 H 
                 5-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 3-13 
                 Me 
                 0 
                 H 
                 6-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 3-14 
                 Et 
                 0 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                 white solid 
                 83-84 
               
               
                 3-15 
                 Et 
                 0 
                 H 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                 pale 
                 79-81 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 yellow solid 
                   
               
               
                 3-16 
                 Et 
                 0 
                 4-Cl 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-17 
                 Et 
                 0 
                 4-Br 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-18 
                 Et 
                 0 
                 4-CF 3   
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-19 
                 Et 
                 0 
                 5-CF 3   
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-20 
                 Et 
                 0 
                 H 
                 5-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 3-21 
                 Et 
                 0 
                 H 
                 5-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 3-22 
                 Et 
                 0 
                 H 
                 5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 3-23 
                 Et 
                 0 
                 H 
                 5-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 3-24 
                 Et 
                 0 
                 H 
                 6-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-25 
                 Et 
                 0 
                 H 
                 6-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 3-26 
                 Et 
                 0 
                 H 
                 6-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 3-27 
                 Et 
                 0 
                 H 
                 6-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 3-28 
                 Et 
                 0 
                 H 
                 6-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 3-29 
                 Et 
                 1 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                 white solid 
                 132-133 
               
               
                 3-30 
                 Et 
                 1 
                 H 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 186-187 
               
               
                 3-31 
                 Et 
                 1 
                 4-Cl 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-32 
                 Et 
                 1 
                 4-Br 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-33 
                 Et 
                 1 
                 4-CF 3   
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-34 
                 Et 
                 1 
                 5-CF 3   
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-35 
                 Et 
                 1 
                 H 
                 5-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 3-36 
                 Et 
                 1 
                 H 
                 5-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 3-37 
                 Et 
                 1 
                 H 
                 5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 3-38 
                 Et 
                 1 
                 H 
                 5-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 3-39 
                 Et 
                 1 
                 H 
                 6-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-40 
                 Et 
                 1 
                 H 
                 6-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 3-41 
                 Et 
                 1 
                 H 
                 6-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 3-42 
                 Et 
                 1 
                 H 
                 6-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 3-43 
                 Et 
                 1 
                 H 
                 6-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 3-44 
                 Et 
                 2 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-45 
                 Et 
                 2 
                 H 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                 white solid 
                 124-126 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 3-2 
               
               
                   
               
               
                 Com- 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 pound 
                   
                   
                   
                   
                   
                   
                   
                 Pro- 
                 Point  
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 file 
                 (° C.) 
               
               
                   
               
             
            
               
                 3-46 
                 Et 
                 2 
                 4-Cl 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-47 
                 Et 
                 2 
                 4-Br 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-48 
                 Et 
                 2 
                 4-CF 3   
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-49 
                 Et 
                 2 
                 5-CF 3   
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-50 
                 Et 
                 2 
                 H 
                 5-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 3-51 
                 Et 
                 2 
                 H 
                 5-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 3-52 
                 Et 
                 2 
                 H 
                 5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 3-53 
                 Et 
                 2 
                 H 
                 5-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 3-54 
                 Et 
                 2 
                 H 
                 6-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-55 
                 Et 
                 2 
                 H 
                 6-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 3-56 
                 Et 
                 2 
                 H 
                 6-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 3-57 
                 Et 
                 2 
                 H 
                 6-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 3-58 
                 Et 
                 2 
                 H 
                 6-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 3-59 
                 n-Hex 
                 0 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-60 
                 n-Hex 
                 0 
                 H 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-61 
                 n-Hex 
                 0 
                 4-Cl 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-62 
                 n-Hex 
                 0 
                 4-Br 
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-63 
                 n-Hex 
                 0 
                 4-CF 3   
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-64 
                 n-Hex 
                 0 
                 5-CF 3   
                 5-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-65 
                 n-Hex 
                 0 
                 H 
                 5-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 3-66 
                 n-Hex 
                 0 
                 H 
                 5-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 3-67 
                 n-Hex 
                 0 
                 H 
                 5-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 3-68 
                 n-Hex 
                 0 
                 H 
                 5-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 3-69 
                 n-Hex 
                 0 
                 H 
                 6-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 3-70 
                 n-Hex 
                 0 
                 H 
                 6-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 3-71 
                 n-Hex 
                 0 
                 H 
                 6-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 3-72 
                 n-Hex 
                 0 
                 H 
                 6-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 3-73 
                 n-Hex 
                 0 
                 H 
                 6-CF 3   
                 I 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 4-1 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 Com- 
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 pound 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 Profile 
                 Point (° C.) 
               
               
                   
               
               
                 4-1 
                 Me 
                 0 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-2 
                 Me 
                 0 
                 H 
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-3 
                 Me 
                 0 
                 H 
                 3-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-4 
                 Me 
                 0 
                 H 
                 2-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 4-5 
                 Me 
                 0 
                 H 
                 3-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 4-6 
                 Me 
                 0 
                 4-CF 3   
                 2-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 4-7 
                 Me 
                 0 
                 4-CF 3   
                 3-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 4-8 
                 Me 
                 0 
                 H 
                 2-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 4-9 
                 Me 
                 0 
                 H 
                 3-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 4-10 
                 Et 
                 0 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                 light 
                 103-105 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 brown solid 
                   
               
               
                 4-11 
                 Et 
                 0 
                 H 
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-12 
                 Et 
                 0 
                 4-Cl 
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-13 
                 Et 
                 0 
                 4-Br 
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-14 
                 Et 
                 0 
                 4-CF 3   
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-15 
                 Et 
                 0 
                 5-CF 3   
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-16 
                 Et 
                 0 
                 H 
                 2-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 4-17 
                 Et 
                 0 
                 H 
                 2-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 4-18 
                 Et 
                 0 
                 H 
                 2-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 4-19 
                 Et 
                 0 
                 H 
                 2-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 4-20 
                 Et 
                 0 
                 H 
                 2,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-21 
                 Et 
                 0 
                 H 
                 2,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 4-22 
                 Et 
                 0 
                 H 
                 2,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 4-23 
                 Et 
                 0 
                 H 
                 2,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 4-24 
                 Et 
                 0 
                 H 
                 2,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 4-25 
                 Et 
                 1 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                 white solid 
                 160-164 
               
               
                 4-26 
                 Et 
                 1 
                 H 
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-27 
                 Et 
                 1 
                 4-Cl 
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-28 
                 Et 
                 1 
                 4-Br 
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-29 
                 Et 
                 1 
                 4-CF 3   
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-30 
                 Et 
                 1 
                 5-CF 3   
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-31 
                 Et 
                 1 
                 H 
                 2-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 4-32 
                 Et 
                 1 
                 H 
                 2-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 4-33 
                 Et 
                 1 
                 H 
                 2-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 4-34 
                 Et 
                 1 
                 H 
                 2-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 4-35 
                 Et 
                 1 
                 H 
                 2,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-36 
                 Et 
                 1 
                 H 
                 2,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 4-37 
                 Et 
                 1 
                 H 
                 2,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 4-38 
                 Et 
                 1 
                 H 
                 2,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 4-39 
                 Et 
                 1 
                 H 
                 2,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 4-40 
                 Et 
                 2 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-41 
                 Et 
                 2 
                 H 
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-42 
                 Et 
                 2 
                 4-Cl 
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-43 
                 Et 
                 2 
                 4-Br 
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-44 
                 Et 
                 2 
                 4-CF 3   
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-45 
                 Et 
                 2 
                 5-CF 3   
                 2-CF 3   
                 H 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                 TABLE 4-2 
               
               
                   
               
               
                 Com- 
                   
                   
                   
                   
                   
                   
                   
                   
                 Melting 
               
               
                 pound 
                   
                   
                   
                   
                   
                   
                   
                 Pro- 
                 Point  
               
               
                 No. 
                 R 
                 n 
                 Xm 
                 Yp 
                 Z 
                 W 1   
                 W 2   
                 file 
                 (° C.) 
               
               
                   
               
             
            
               
                 4-46 
                 Et 
                 2 
                 H 
                 2-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 4-47 
                 Et 
                 2 
                 H 
                 2-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 4-48 
                 Et 
                 2 
                 H 
                 2-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 4-49 
                 Et 
                 2 
                 H 
                 2-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 4-50 
                 Et 
                 2 
                 H 
                 2,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-51 
                 Et 
                 2 
                 H 
                 2,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 4-52 
                 Et 
                 2 
                 H 
                 2,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 4-53 
                 Et 
                 2 
                 H 
                 2,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 4-54 
                 Et 
                 2 
                 H 
                 2,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 4-55 
                 n-Hex 
                 0 
                 H 
                 H 
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-56 
                 n-Hex 
                 0 
                 H 
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-57 
                 n-Hex 
                 0 
                 4-Cl 
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-58 
                 n-Hex 
                 0 
                 4-Br 
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-59 
                 n-Hex 
                 0  
                 4-CF 3   
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-60 
                 n-Hex 
                 0  
                 5-CF 3   
                 2-CF 3   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-61 
                 n-Hex 
                 0 
                 H 
                 2-CF 3   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 4-62 
                 n-Hex 
                 0 
                 H 
                 2-CF 3   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 4-63 
                 n-Hex 
                 0 
                 H 
                 2-CF 3   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 4-64 
                 n-Hex 
                 0 
                 H 
                 2-CF 3   
                 I 
                 CH 
                 CH 
                   
                   
               
               
                 4-65 
                 n-Hex 
                 0 
                 H 
                 2,5-(CF 3 ) 2   
                 H 
                 CH 
                 CH 
                   
                   
               
               
                 4-66 
                 n-Hex 
                 0 
                 H 
                 2,5-(CF 3 ) 2   
                 Me 
                 CH 
                 CH 
                   
                   
               
               
                 4-67 
                 n-Hex 
                 0 
                 H 
                 2,5-(CF 3 ) 2   
                 Cl 
                 CH 
                 CH 
                   
                   
               
               
                 4-68 
                 n-Hex 
                 0 
                 H 
                 2,5-(CF 3 ) 2   
                 Br 
                 CH 
                 CH 
                   
                   
               
               
                 4-69 
                 n-Hex 
                 0 
                 H 
                 2,5-(CF 3 ) 2   
                 I 
                 CH 
                 CH 
               
               
                   
               
            
           
         
       
     
     Next, the production method of the 1,2,3-triazole derivative (1) of the present invention is described in detail below. Incidentally, as for the reaction apparatus, a reaction using a microwave synthesis apparatus may also be possible, in addition to using a magnetic stirrer or a mechanical stirrer. 
                         
(R, n, X, m, W 1 , W 2  and Q have the same meanings as R, n, X, m, W 1 , W 2  and Q in formula (1), and Z 1  represents a hydrogen atom or a halogen atom).
 
     The step-1 is a step of reacting an azide derivative represented by formula (2) and an acetylene derivative represented by formula (3) to produce a 1,2,3-triazole derivative (1a). The azide derivative represented by formula (2) and the acetylene derivative represented by formula (3) are known depending on the case and are available, for example, from Tokyo Chemical Industry Co., Ltd. Alternatively, these derivatives may also be easily produced from an available reagent in conformity with a known method described in  Experimental Chemistry Course, Organic Syntheses , etc. 
     In this reaction, the derivatives must be reacted in the presence of a monovalent or divalent copper reagent, and specific examples of the copper reagent include copper(I) chloride, copper(II) chloride, copper(I) bromide, copper(II) bromide, copper(I) iodide, copper(I) acetate, copper(II) acetate, copper(II) hydroxide, copper(I) triflate, copper(I) 2-thiophenecarboxylate, and copper(II) sulfate. Depending on the case, a combination with a reducing agent such as sodium ascorbate may be required. The derivatives are reacted using such a copper reagent in an amount of 0.01 to 1 equivalent relative to the substrate (2), and the target compound can thereby be efficiently obtained. The reactant (3) is usually used in an amount of 1 to 5 equivalents relative to the substrate (2). 
     The reaction above can be performed either in the absence of a solvent or in the presence of a solvent. As the solvent used, a solvent not adversely affecting the reaction may be used, and an aromatic hydrocarbon-based solvent such as benzene, toluene, xylene and chlorobenzene, an aliphatic hydrocarbon-based solvent such as pentane, hexane and octane, an ether-based solvent such as diethyl ether, diisopropyl ether, cyclopentylmethyl ether, tetrahydrofuran, dimethoxyethane and 1,4-dioxane, ketones such as acetone, methyl ethyl ketone and cyclohexanone, a halogen-based solvent such as chloroform and dichloromethane, a nitrile-based solvent such as acetonitrile and propionitrile, an ester-based solvent such as ethyl acetate, n-propyl acetate, n-butyl acetate and methyl propionate, an amide-based solvent such as N,N′-dimethylformamide, N,N′-dimethylacetamide and N-methylpyrrolidone, an alcohol-based solvent such as methanol, ethanol, 1-propanol, 2-propanol and tert-butanol, dimethyl sulfoxide, water, or a mixed solvent thereof may be used. 
     The reaction may be performed at a temperature appropriately selected in the range from −78° C. to 200° C., though this may vary depending on the reaction conditions. After the completion of reaction, the target compound can be obtained by performing a normal post-treatment operation but, if desired, the obtained compound may be purified by column chromatography, recrystallization, etc. 
     In addition, when Z 1  is H, the obtained 1,2,3-triazole derivative may be reacted with an electrophile in the presence of a base such as butyllithium or lithium diisopropylamide and thereby be led to a desired 5-substituted-1,2,3-triazole derivative. 
                         
(R, n, X, m, W 1 , W 2  and Q have the same meanings as R, n, X, m, W 1 , W 2  and Q in formula (1)).
 
     The step-2 is a step of reacting an azide derivative represented by formula (2) and a substituted acetonitrile derivative represented by formula (4) to produce a 5-amino-1,2,3-triazole derivative (1b). The substituted acetonitrile derivative represented by formula (4) is known depending on the case and is available from Tokyo Chemical Industry Co., Ltd., etc. Alternatively, this derivative may also be easily produced from an available reagent in conformity with a known method described, for example, in  Experimental Chemistry Course  and  Organic Syntheses.    
     This reaction must be performed in the presence of a base, and the base that can be used includes, for example, an organic base such as triethylamine, diisopropylethylamine, tri(n-butyl)amine, N-methylmorpholine, N,N′-dimethylaniline, N,N′-diethylaniline, 4-tert-butyl-N,N′-dimethylaniline, pyridine, picoline and lutidine, and an alkali metal salt such as sodium carbonate, potassium carbonate, sodium hydrogencarbonate, potassium hydrogencarbonate, sodium acetate, potassium acetate, sodium methoxide, sodium ethoxide, potassium-tert-butoxide, sodium hydride, potassium hydride, sodium amide, n-butyllithium, tert-butyllithium, lithium diisopropylamide, trimethylsilyl lithium and lithium hexamethyldisilazide. Among these bases, a metal base such as sodium methoxide and sodium ethoxide is preferred in view of good yield. The derivatives above are reacted using the base in an amount of 0.1 to 5 equivalents relative to the substrate, and the target compound can thereby be efficiently obtained. The reactant (4) is used usually in an amount of 1 to 5 equivalents relative to the substrate (2). 
     The reaction above can be performed either in the absence of a solvent or in the presence of a solvent. As the solvent used, a solvent not adversely affecting the reaction may be used, and an aromatic hydrocarbon-based solvent such as benzene, toluene, xylene and chlorobenzene, an aliphatic hydrocarbon-based solvent such as pentane, hexane and octane, an ether-based solvent such as diethyl ether, diisopropyl ether, cyclopentylmethyl ether, tetrahydrofuran, dimethoxyethane and 1,4-dioxane, ketones such as acetone, methyl ethyl ketone and cyclohexanone, a halogen-based solvent such as chloroform and dichloromethane, a nitrile-based solvent such as acetonitrile and propionitrile, an ester-based solvent such as ethyl acetate, n-propyl acetate, n-butyl acetate and methyl propionate, an amide-based solvent such as N,N′-dimethylformamide, N,N′-dimethylacetamide and N-methylpyrrolidone, an alcohol-based solvent such as methanol, ethanol, 1-propanol, 2-propanol and tert-butanol, dimethyl sulfoxide, water, or a mixed solvent thereof may be used. 
     The reaction may be performed at a temperature appropriately selected in the range from −78° C. to 200° C., though this may vary depending on the base used or the reaction conditions. After the completion of reaction, the target compound can be obtained by performing a normal post-treatment operation but, if desired, the obtained compound may be purified by column chromatography, recrystallization, etc. 
     In addition, the obtained 5-amino-1,2,3-triazole derivative may be reacted with an electrophile and thereby be led to a 5-substituted amino-1,2,3-triazole derivative. 
                         
(R, n, X, m, W 1 , W 2  and Q have the same meanings as R, n, X, m, W 1 , W 2  and Q in formula (1), and R 2  represents a phenyl group that may be substituted, or a C1-C6 alkyl group).
 
     The step-3 is a step of reacting an aniline derivative represented by formula (5), an acetyl derivative represented by formula (6), and a substituted sulfonyl hydrazide derivative represented by formula (7) in the presence of iodine to produce a 1,2,3-triazole derivative (1c). The aniline derivative represented by formula (5), the acetyl derivative represented by formula (6), and the substituted sulfonyl hydrazide derivative represented by formula (7) are known depending on the case and are available, for example, from Tokyo Chemical Industry Co., Ltd. Alternatively, these derivatives may also be easily produced from an available reagent in conformity with a known method described in  Experimental Chemistry Course, Organic Syntheses , etc. In this step, the synthesis may be performed in conformity with the method described in the document ( Chemistry A European Journal , (2014), 20, 17635-17639). 
     In addition, the obtained 1,2,3-triazole derivative may be reacted with an electrophile in the presence of a base such as butyllithium or lithium diisopropylamide and thereby be led to a desired 5-substituted-1,2,3-triazole derivative. 
                         
(R, n, X, m, W 1 , W 2  and Q have the same meanings as R, n, X, m, W 1 , W 2  and Q in formula (1), R 2  represents a phenyl group that may be substituted, or a C1-C6 alkyl group, and R 11  represents a hydrogen atom, a C1-C6 alkyl group, or a C1-C6 cycloalkyl group).
 
     The step-4 is a step of reacting a ketone derivative represented by formula (8) and a substituted sulfonyl hydrazide derivative represented by formula (7), and then reacting an aniline derivative represented by formula (5) in the presence of copper acetate to produce a 1,2,3-triazine derivative (1d). In this step, the synthesis may also be performed in conformity with the method described in the document ( Chemistry A European Journal , (2014), 20, 13692-13697). 
                         
(R, n, X, m, W 1 , W 2  and Q have the same meanings as R, n, X, m, W 1 , W 2  and Q in formula (1), and M represents a halogen atom or an alkylsulfonyl group).
 
     The step-5 is a step of reacting a triazole derivative represented by formula (1e) with formula (5a) to produce a 1,2,3-triazole derivative (1c). 
     This reaction is preferably performed in the presence of a base, and the base that can be used includes, for example, an organic base such as triethylamine, diisopropylethylamine, tributylamine, N-methylmorpholine, N,N′-dimethylaniline, N,N′-diethylaniline, 4-tert-butyl-N,N′-dimethylaniline, pyridine, picoline and lutidine, and an alkali metal salt such as sodium carbonate, potassium carbonate, sodium hydrogencarbonate, potassium hydrogencarbonate, sodium acetate, potassium acetate, sodium methoxide, sodium ethoxide, potassium-tert-butoxide, sodium hydride, potassium hydride, sodium amide, butyllithium, tert-butyllithium, lithium diisopropylamide, trimethylsilyl lithium and lithium hexamethyldisilazide. Among these bases, a metal base such as sodium methoxide and sodium ethoxide is preferred in view of good yield. The reaction is performed using the base in an amount of 1 to 5 equivalents relative to the substrate, and the target compound can thereby be efficiently obtained. 
     The reaction above can be performed either in the absence of a solvent or in the presence of a solvent. As the solvent, a solvent not adversely affecting the reaction may be used, and an aromatic hydrocarbon-based solvent such as benzene, toluene, xylene and chlorobenzene, an aliphatic hydrocarbon-based solvent such as pentane, hexane and octane, an ether-based solvent such as diethyl ether, diisopropyl ether, cyclopentylmethyl ether, tetrahydrofuran, dimethoxyethane and 1,4-dioxane, ketones such as acetone, methyl ethyl ketone and cyclohexanone, a halogen-based solvent such as chloroform and dichloromethane, a nitrile-based solvent such as acetonitrile and propionitrile, an ester-based solvent such as ethyl acetate, n-propyl acetate, n-butyl acetate and methyl propionate, an amide-based solvent such as N,N′-dimethylformamide, N,N′-dimethylacetamide and N-methylpyrrolidone, an alcohol-based solvent such as methanol, ethanol, 1-propanol, 2-propanol and tert-butanol, dimethyl sulfoxide, water, or a mixed solvent thereof may be used. 
     The reaction may be performed at a temperature appropriately selected in the range from −78° C. to 200° C., though this may vary depending on the base used or the reaction conditions. After the completion of reaction, the target compound can be obtained by performing a normal post-treatment operation but, if desired, the obtained compound may be purified by column chromatography, recrystallization, etc. 
                         
(R, X, m, W 1 , W 2  and Q have the same meanings as R, X, m, W 1 , W 2  and Q in formula (1), and M has the same meaning as M in formula (5a)).
 
     The step-6 is a step of reacting a triazole derivative represented by formula (1f) with thiols represented by formula (8) to produce a 1,2,3-triazole derivative (1g). 
     This reaction must be performed in the presence of a base, and the base that can be used includes, for example, an organic base such as triethylamine, diisopropylethylamine, tributylamine, N-methylmorpholine, N,N′-dimethylaniline, N,N′-diethylaniline, 4-tert-butyl-N,N′-dimethylaniline, pyridine, picoline and lutidine, and an alkali metal salt such as sodium carbonate, potassium carbonate, sodium hydrogencarbonate, potassium hydrogencarbonate, sodium acetate, potassium acetate, sodium methoxide, sodium ethoxide, potassium-tert-butoxide, sodium hydride, potassium hydride, sodium amide, butyllithium, tert-butyllithium, lithium diisopropylamide, trimethylsilyl lithium and lithium hexamethyldisilazide. Among these bases, a metal base such as sodium methoxide and sodium ethoxide is preferred in view of good yield. The reaction is performed using the base in an amount of 1 to 5 equivalents relative to the substrate, and the target compound can thereby be efficiently obtained. Depending on the case, a thiol salt of compound (8) may be prepared and then reacted. 
     In addition, this reaction may also be performed in the presence of a transition metal catalyst such as copper, palladium, rhodium and ruthenium to obtain a compound (1g). As the transition metal catalyst, specifically, copper(I) iodide or tris(dibenzylideneacetone)dipalladium(0) may be used. 
     The reaction above can be performed either in the absence of a solvent or in the presence of a solvent. As the solvent, a solvent not adversely affecting the reaction may be used, and an aromatic hydrocarbon-based solvent such as benzene, toluene, xylene and chlorobenzene, an aliphatic hydrocarbon-based solvent such as pentane, hexane and octane, an ether-based solvent such as diethyl ether, diisopropyl ether, cyclopentylmethyl ether, tetrahydrofuran, dimethoxyethane and 1,4-dioxane, ketones such as acetone, methyl ethyl ketone and cyclohexanone, a halogen-based solvent such as chloroform and dichloromethane, a nitrile-based solvent such as acetonitrile and propionitrile, an ester-based solvent such as ethyl acetate, propyl acetate, butyl acetate and methyl propionate, an amide-based solvent such as N,N′-dimethylformamide, N,N′-dimethylacetamide and N-methylpyrrolidone, an alcohol-based solvent such as methanol, ethanol, 1-propanol, 2-propanol and tert-butanol, dimethyl sulfoxide, water, or a mixed solvent thereof may be used. 
     The reaction may be performed at a temperature appropriately selected in the range from −78° C. to 200° C., though this may vary depending on the base used or the reaction conditions. After the completion of reaction, the target compound can be obtained by performing a normal post-treatment operation but, if desired, the obtained compound may be purified by column chromatography, recrystallization, etc. 
                         
(R, X, m, Z, W 1 , W 2  and Q have the same meanings as R, X, m, Z, W 1 , W 2  and Q in formula (1), and q represents an integer of 1 to 2).
 
     A compound represented by formula (1i) according to the present invention can be produced, for example, by reacting a compound represented by formula (1h) with an oxidizer. 
     As the oxidizer for use in this reaction, hydrogen peroxide, m-chloroperbenzoic acid, sodium periodate, OXONE (trade name of E.I. DuPont, an oxidizer containing potassium hydrogenperoxosulfate), N-chlorosuccinimide, N-bromosuccinimide, tert-butyl hypochlorite, sodium hypochlorite, oxygen, etc. can be used. Among these oxidizers, m-chloroperbenzoic acid, hydrogen peroxide, etc. are preferred in view of good yield. Such an oxidizer is preferably used in the range of 0.01 to 10 equivalents relative to the substrate so as not to adversely affect the progress of reaction, and use in the range of 1 to 3 equivalents is preferred, because the target compound can be obtained with good yield. 
     As the catalyst for use in this reaction, for example, molybdenum oxide, boric acid, tris(acetylacetone) iron and sodium tungstate may be used, and molybdenum oxide, etc. are preferred. The reaction is performed using such a catalyst in an amount of 0.01 to 1 equivalent relative to the substrate (1h), and the target compound can thereby be efficiently obtained. 
     This reaction is preferably conducted in a solvent. As for the solvent, a solvent not adversely affecting the reaction may be used, and an ether-based solvent such as diethyl ether, tetrahydrofuran and dioxane, an aromatic hydrocarbon-based solvent such as benzene, toluene, xylene and chlorobenzene, a nitrile-based solvent such as acetonitrile and propionitrile, an amide-based solvent such as N,N′-dimethylformamide, N,N′-dimethylacetamide and N-methylpyrrolidone, an alcohol-based solvent such as methanol, ethanol and isopropyl alcohol, a halogen-based solvent such as dichloromethane, chloroform and 1,2-dichloroethane, an aliphatic hydrocarbon-based solvent such as pentane, hexane, cyclohexane and cycloheptane, ketones such as acetone, methyl ethyl ketone and cyclohexanone, an alcohol-based solvent such as methanol, ethanol, 1-propanol, 2-propanol and tert-butanol, acetic acid, water, or a mixed solvent thereof may be used. 
     The reaction may be performed at a temperature appropriately selected in the range from −78° C. to the solvent reflux temperature, though this may vary depending on the reaction conditions. After the completion of reaction, the target compound can be obtained by performing a normal post-treatment operation but, if desired, the obtained compound may be purified by column chromatography, recrystallization, etc. 
     The compound of the present invention may be, if desired, analyzed, confirmed or identified by the melting point, infrared absorption spectrum,  1 H-NMR,  13 C-NMR, mass spectrometry, X-ray structural analysis, etc. 
     The compound of the present invention is useful as an active ingredient of agricultural/horticultural pest control agents, among others, insecticides or acaricides. 
     The compound of the present invention can also exert an excellent activity in controlling a wide range of insects, mites, crustaceans, mollusks, and nematodes. Specific examples of the agricultural/horticultural pests include the followings: 
     for example, insects from the order Thysanura, for example, Ctenolepisma villosa, Lepisma saccharina, and  Thermobia domestica,    
     from the order Blattodea, for example,  Periplaneta americana, Periplaneta fuliginosa, Periplaneta japonica, Blattella germanica , and  Blattella lituricollis,    
     from the order Isoptera, for example,  Incisitermes minor, Coptotermes formosanus, Reticulitermes speratus , and  Odontotermes formosanus, from the order Orthoptera, for example, Ruspolia lineosa, Teleogryllus emma, Gryllotalpa orientalis, Locusta migratoria , and  Oxya yezoensis,    
     from the order Psocoptera, for example,  Trogium pulsatorium, Liposcelis bostrychophila , and  Liposcelis corrodens,    
     from the order Mallophaga, for example,  Lipeurus caponis, Menacanthus stramineus, Damalinia bovis , and  Damalinia caprae,    
     from the order Anoplura, for example,  Haematopinus eurysternus, Haematopinus suis, Pediculus humanus capitis, Pediculus humanus humanus , and  Pthirus pubis,    
     from the order Thysanoptera, for example,  Frankliniella intonsa, Frankliniella occidentalis, Heliothrips haemorrhoidalis, Mycterothrips glycines, Scirtothrips dorsalis, Stenchaetothrips biformis, Thrips palmi, Thrips tabaci, Haplothrips aculeatus , and  Ponticulothrips diospyrosi,    
     from the order Hemiptera, for example,  Arboridia apicalis, Empoasca onukii, Nephotettix cincticeps, Laodelphax striatella, Nilaparvata lugens, Sogatella furcifera, Geisha distinctissima, Diaphorina citri, Viteus vitifoliae, Acyrthosiphon pisum, Aphis craccivora, Aphis gossypii, Aphis pomi, Aphis spiraecola, Aulacorthum solani, Eriosoma lanigerum, Hyalopterus pruni, Lipaphis erysimi, Myzus persicae, Rhopalosiphum padi, Schizaphis graminum, Schizaphis piricola, Toxoptera aurantii, Toxoptera citricida, Aleurocanthus spiniferus, Bemisia argentifolii, Bemisia tabaci, Dialeurodes citri, Trialeurodes vaporariorum, Drosicha corpulenta, Icerya purchasi, Planococcus citri, Planococcus kraunhiae, Pseudococcus comstocki, Ceroplastes ceriferus, Ceroplastes rubens, Aonidiella aurantii, Diaspidiotus perniciosus, Pseudaulacaspis pentagona, Unaspis yanonensis, Creontiades coloripes, Trigonotylus caelestialium, Stephanitis nashi, Stephanitis pyrioides, Eysarcoris aeneus, Eysarcoris lewisi, Glaucias subpunctatus, Graphosoma rubrolineatum, Halyomorpha halys, Nezara antennata, Nezara viridula, Plautia crossota stali, Cavelerius saccharivorus, Togo hemipterus, Leptocorisa chinensis, Riptortus clavatus, Cletus punctiger, Rhopalus maculatus , and  Cimex lectularis,    
     from the order Coleoptera, for example,  Anomala albopilosa, Anomala cuprea, Anomala rufocuprea, Eucetonia pilifera, Gametis jucunda, Heptophylla picea, Popillia japonica, Agriotes ogurae fuscicollis, Ectinus sericeus sericeus, Melanotus fortnumi fortnumi, Anthrenus verbasci, Lasioderma serricorne, Tenebroides mauritanicus, Epuraea domina, Epilachna varivestis, Henosepilachna vigintioctopunctata, Tenebrio molitor, Tribolium castaneum, Anoplophora malasiaca, Monochamus alternatus endai, Xylotrechus pyrrhoderus, Callosobruchus chinensis, Aulacophora femoralis, Cassida nebulosa, Chaetocnema concinna, Diabrotica virgifera virgifera, Diabrotica undecimpunctata howardi, Diabrotica  spp.,  Leptinotarsa decemlineata, Oulema oryzae, Phyllotreta striolata, Cylas formicarius, Anthonomus grandis, Euscepes postfasciatus, Hypera postica, Listroderes costirostris, Echinocnemus bipunctatus, Lissorhoptrus oryzophilus, Sitophilus zeamais, Sphenophrus venatus vestitus, Tomicus piniperda , and  Lyctus brunneus,    
     from the order Siphonaptera, for example,  Ceratophyllus gallinae, Ctenocephalides canis, Ctenocephalides felis, Echidnophaga gallinacea, Pulex irritans , and  Xenopsylla cheopis,    
     from the order Diptera, for example,  Asphondylia yushimai, Aedes aegypti, Anopheles sinensis, Culex pipines pallens, Culex quinquefasciatus, Culex tritaeniorhynchus, Bactrocera cucurbitae, Bactrocera dorsalis, Agromyza oryzae, Chromatomyia horticola, Liriomyza huidobrensis, Liriomyza sativae, Liriomyza trifolii, Delia antiqua, Delia platura, Musca domestica , and  Stomoxys calcitrans,    
     from the order Lepidoptera, for example,  Adoxophyes honmai, Adoxophyes orana fasciata, Archips fuscocupreanus, Cydia pomonella, Grapholita molesta, Homona magnanima, Leguminivora glycinivorella, Pandemis heparana, Tinea translucens, Lyonetia clerkella, Lyonetia prunifoliella malinella, Caloptilia theivora, Phyllonorycter ringoniella, Phyllocnistis citrella, Plutella xylostella, Nokona regalis, Synanthedon hector, Stathmopoda masinissa, Helcystogramma triannulellum, Pectinophora gossypiella, Carposina sasakii, Chilo suppressalis, Cnaphalocrocis medinalis, Conogethes punctiferalis, Hellula undalis, Ostrinia furnacalis, Ostrinia nubilalis, Etiella zinckenella, Papilio xuthus, Pieris rapae crucivora, Parnara guttata guttata, Ascotis selenaria, Arna pseudoconspersa, Lymantria dispar, Hyphantria cunea, Agrotis ipsilon, Agrotis segetum, Autographa nigrisigna, Helicoverpa armigera, Heliothis  spp.,  Mamestra brassicae, Mythimna separata, Naranga aenescens, Spodoptera exigua , and  Spodoptera litura , and 
     from the order Hymenoptera, for example,  Arge pagana, Athalia rosae ruficornis, Dryocosmus kuriphilus, Vespa simillima xanthoptera, Formica japonica, Monomorium pharaonis , and  Solenopsis invicta;    
     mites, for example,  Varroa jacobsoni, Dermanyssus gallinae, Ornithonyssus bacoti, Ornithonyssus sylvialum, Amblyomma  spp.,  Boophilus microplus, Dermacentor  spp.,  Haemaphysalis flava, Haemophysalis campanulata, Haemaphysalis longicornis, Ixodes ovatus, Ixodes persulcatus, Rhipicephalus sanguineus, Penthaleus erythrocephalus, Penthaleus major, Phytonemus pallidus, Polyphagotarsonemus latus, Tarsonemus bilobatus, Demodex canis, Demodex cati, Oligonychus shinkajii, Panonychus citri, Panonychus mori, Panonychus ulmi, Tetranychus cinnabarinus, Tetranychus kanzawai, Tetranychus urticae, Acaphylla theavagrans, Aceria tulipae, Aculops lycopersici, Aculops pelekassi, Aculus schlechtendali, Calacarus carinatus, Epitrimerus pyri, Eriophyes chibaensis, Phyllocoptruta oleivora, Rhizoglyphus robini, Tyrophagus putrescentiae, Tyrophagus similis, Knemidokoptes  spp.,  Psoroptes ovis, Notoedres cati, Sarcoptes scabiei, Leptotrombidium akamushi, Cheyletiella blakei, Cheyletiella yasguri, Dermatophagoides farinae , and  Latrodectus hasseltii;    
     crustaceans from the order Polydesmida, for example,  Oxidus gracilis,    
     from the order Isopoda, for example,  Armadillidium vulgare,    
     from the order Decapoda, for example,  Procambarus clarkia , and 
     from the order Collembola, for example,  Bourletiella hortensis;    
     mollusks from the order Architaenioglossa, for example,  Pomacea canaliculata , and 
     from the order Pulmonata, for example,  Achatina fulica, Meghimatium bilineatum, Lehmannina valentiana , and  Acusta despecta sieboldiana ; and 
     nematodes from the order Tylenchida, for example,  Nothotylenchus acris, Meloidogyne incognita, Globodera rostochiensis, Heterodera glycines, Tylenchulus semipenetrans, Pratylenchus coffeae, Pratylenchus penetrans, Pratylenchus yamagutii, Aphelenchus avenae, Aphelenchoides besseyi , and  Bursaphelenchus xylophilus.    
     In addition, the pests include endoparasites in animals, such as roundworms, pinworms, filarial worms, distoma hepaticum, pulmonary distomiasis, metagonimus yuokogawa, Schistosoma japonicum, Taenia solium, Taenia saginata, Echinococcus multilocularis, and diphyllobothrium latum. 
     The compound of the present invention can be used as an agricultural/horticultural pest controlling ingredient. At the time of formulation, an appropriate carrier, adjuvant, surfactant, binder, stabilizer, etc. described in  Pesticide Formulation Guide  (edited by: Pesticide Science Society of Japan, Agricultural Formulation and Application Committee, issued by: Japan Plant Protection Association) may also be blended. 
     The agricultural/horticultural pest control agent containing the compound of the present invention can be formulated into an arbitrary form that is generally employed as a form of the agricultural/horticultural pest control agent. For example, the pest control agent may be formulated into a generally employed form such as dust, coarse dust, DL (driftless type) dust, flow dust, microgranule, fine granule, granule, wettable powder, granular wettable powder, liquid formulation, sol (flowable formulation), emulsifiable concentrate, and oil solution, but the formulation is not limited thereto. 
     The content of the compound of the present invention may be appropriately selected according to the formulation form and use method. In general, the content is preferably from 0.0001 to 90 wt % relative to the total amount of the formulation. 
     In the case of using the compound of the present invention as an agricultural/horticultural pest control agent, one or more optional ingredients selected from fungicides (mildewcide, bactericide, antiviral agent, plant resistance inducing agent), insecticides, acaricides, nematicides, herbicides, bird repellents, growth regulators, fertilizers, soil conditioners, etc. may be mixed, if desired, at the time of formulation or spraying to provide a mixed formulaion or may be mixed and applied as a tankmix at the time of spraying. 
     Out of the above-described optional ingredients, representative examples of fungicides and insecticides or acaricides are described below, but the present invention is not limited thereto. 
     Fungicides: 
     (1) Copper Agents 
     Basic copper chloride (copper oxychloride), basic copper sulfate (copper sulfate), cupric hydroxide (copper hydroxide), copper sulfate, oxine-copper, copper nonylphenyl sulfonate, DBEDC, etc. 
     (2) Inorganic Fungicides 
     Sulfur, lime-sulfur mixture (calcium polysulfide), sodium hydrogen carbonate, potassium hydrogen carbonate, metallic silver (silver), etc. 
     (3) Organosulfur Fungicides 
     Ziram, maneb, mancozeb, ambam, polycarbamate, propineb, thiuram, thiadiazin, zineb, etc. 
     (4) Organophosphorus Fungicides 
     IBP, EDDP, tolclofos-methyl, pyrazophos, fosetyl (fosetyl-alminium), etc. 
     (5) Benzimidazole Fungicides 
     Carbendazim, thiabendazole, thiophanate-methyl, benomyl, etc. 
     (6) Dicarboxamide Fungicides 
     Iprodione, procymidone, vinclozolin, etc. 
     (7) Carboxamide Fungicides 
     Oxycarboxin, carboxin, mepronil, flutolanil, boscalid, fluopyram, furametpyr, thifluzamide, penthiopyrad, bixafen, penflufen, fluxapyroxad, isopyrazam, tolfenpyrad, sedaxane, etc. 
     (8) Phenylamide Fungicides 
     Metalaxyl, metalaxyl-M, oxadixyl, furalaxyl, ofurace, benalaxyl, benalaxyl-M, etc. 
     (9) Carboxylic acid Amide Fungicides 
     Dimethomorph, flumorph, iprovalicarb, benthiavalicarb-isopropyl, mandipropamid, valifenalate, etc. 
     (10) SBI Agents 
     Triflumizole, prochloraz, oxpoconazole fumarate, triadimefon, bitertanol, myclobutanil, fenbuconazole, hexaconazole, tebuconazole, propiconazole, prothioconazole, difenoconazole, ipconazole, imibenconazole, cyproconazole, tetraconazole, simeconazole, metconazole, epoxiconazole, flusilazole, imazalil, fenarimol, triforine, triadimenol, flutriafol, pyrifenox, tridemorph, dodemorph, fenpropimorph, fenpropidin, spiroxamine, pyrisoxazole, fenhexamid, pyributicarb, etc. 
     (11) Strobilurin Fungicides 
     Azoxystrobin, kresoxim-methyl, trifloxystrobin, metominostrobin, orysastrobin, pyraclostrobin, enestroburin, dimoxystrobin, picoxystrobin, pyribencarb, fluoxastrobin, etc. 
     (12) Anilinopyrimidine Fungicides 
     Cyprodinil, mepanipyrim, pyrimethanil, etc. 
     (13) Phenylpyrrole Fungicides 
     Fludioxonil, fenpiclonil, etc. 
     (14) Antibiotic Fungicides 
     Kasugamycin, polyoxin, validamycin, streptomycin, oxytetracycline, blasticidin-S, etc. 
     (15) Other Fungicides 
     DKF-1001 (code No.), IKF-5411 (code No.), MIF-1002 (code No.), NC-233 (code No.), S-2200 (code No.), SB-4303 (code No.), acibenzolar-S-methyl, amisulbrom, ametoctradin, isotianil, isoprothiolane, iminoctadine-albesilate (iminoctadine tris(albesilate)), iminoctadine acetate (iminoctadine triacetate), echlomezol, ethaboxam, oxolinic acid, captafol, carpropamid, quinoxyfen, chinomethionat, captan, chloroneb, chlorothalonil, cyazofamid, diethofencarb, diclocymet, diclomezine, dithianon, cyflufenamid, diflumetorim, cymoxanil, silthiofam, zoxamide, dazomet, tiadinil, teclofthalam, tebufloquin, dodine, triazoxide, tricyclazole, tolnifanide, hydroxyisoxazole, pyriofenone, pyroquilon, fenoxanil, ferimzone, fenpyrazamine, phthalide, bupirimate, famoxadone, fenamidone, fluazinam, fluopicolide, fluoroimide, flusulfamide, flutianil, proquinazid, propamocarb hydrochloride, probenazole, pencycuron, folpet, methasulfocarb, metrafenone, laminarin, etc. 
     Insecticides: 
     (1) Organophosphorus Insecticides 
     Acephate, azinphos-methyl, chlorfenvinphos, chlorpyrifos, chlorpyrifos-methyl, cyanophos, diazinon, dichlofenthion, dichlorvos, dimethoate, dimethylvinphos, disulfoton, EPN, ethion, ethoprophos, fenamiphos, fenitrothion, fenthion, isofenphos, isoxathion, malathion, methidathion, mevinphos, monocrotophos, naled, oxydemeton-methyl, parathion, parathion-methyl, phenthoate, phorate, phosalone, phosmet, phosphamidon, phoxim, pirimiphos-methyl, profenofos, propaphos, prothiofos, pyraclofos, pyridaphenthion, quinalphos, tebupirimfos, temephos, terbufos, tetrachlorvinphos, thiometon, trichlorfon, vamidothion, etc. 
     (2) Carbamate Insecticides 
     Aldicarb, alanycarb, bendiocarb, benfuracarb, carbaryl, carbofuran, carbosulfan, ethiofencarb, fenobucarb, fenoxycarb, furathiocarb, isoprocarb, methiocarb, methomyl, metolcarb, oxamyl, pirimicarb, propoxur, thiodicarb, triazamate, XMC, xylylcarb, etc. 
     (3) Pyrethroid Insecticides 
     Acrinathrin, allethrin, bifenthrin, cycloprothrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, lambda-cyhalothrin, gamma-cyhalothrin, cypermethrin, alpha-cypermethrin, theta-cypermethrin, deltamethrin, esfenvalerate, etofenprox, fenpropathrin, fenvalerate, flucythrinate, fluvalinate, tau-fluvalinate, halfenprox, metofluthrin, permethrin, phenothrin (phenothrin[(1R)-trans-isomer]), pyrethrins, resmethrin, silafluofen, tefluthrin, tetramethrin, tralomethrin, etc. 
     (4) Nereistoxin Insecticides 
     Bensultap, cartap, thiocyclam, etc. 
     (5) Neonicotinoid Insecticides 
     Acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam, etc. 
     (6) Diamide Insecticides 
     Chlorantraniliprole, cyantraniliprole, flubendiamide, cyclaniliprole, etc. 
     (7) Phenylpyrazole Insecticides 
     Acetoprole, ethiprole, fipronil, flufiprole, pyrafluprole, pyriprole, etc. 
     (8) Macrolide Insecticides 
     Abamectin, avermectin, emamectin benzoate, lepimectin, milbemectin, spinetoram, spinosad, etc. 
     (9) Benzoylurea Insecticides 
     Bistrifluron, chlorfluazuron, diflubenzuron, fluazuron, flucycloxuron, flufenoxuron, hexaflumuron, lufenuron, novaluron, noviflumuron, teflubenzuron, triflumuron, etc. 
     (10) Diacylhydrazine Insecticides 
     Chromafenozide, halofenozide, methoxyfenozide, tebufenozide, etc. 
     (11) Other Insecticide Active Ingredients 
     Azadiractin, buprofezin, chinomethionat, chlorfenapyr, cyromazine, diafenthiuron, dicofol, dienochlor, endosulfan, flometquin, flonicamid, flufenerim, flupyradifurone, hydramethylnon, hydroprene, indoxacarb, metaflumizone, metaldehyde, methoprene, methoxychlor, pymetrozine, pyridalyl, pyrifluquinazone, pyriproxyfen, rotenone, spirotetramat, sulfoxaflor, tolfenpyrad, triflumezopyrim, AKD-1193 (code No.), MIE-1209 (code No.), NA-89 (code No.), NC-515 (code No.), ME5382 (code No.), ZDI-2501 (code No.), sodium oleate, diatomaceous earth, fatty acid glyceride, starch, rapeseed oil, sticker (polybutene), propylene glycol monofatty acid ester, machine oil (petroleum oil), nicotine-sulfate, ferric phosphate, etc. 
     (12) Acaricides 
     Acequinocyl, amidoflumet, amitraz, bifenazate, bromopropylate, clofentezine, cyenopyrafen, cyflumetofen, cyhexatin, etoxazole, fenazaquin, fenbutatin oxide, fenothiocarb, fenpyroximate, fluacrypyrim, hexythiazox, propargite, pyrimidifen, pyridaben, spirodiclofen, spiromesifen, tebufenpyrad, tetradifon, etc. 
     (13) Nematicides 
     Aldoxycarb, cadusafos, carbam sodium, 1,3-dichloropropene, DCIP, fluensulfone, fosthiazate, imicyafos, levamisol hydrochloride, mesulfenfos, methyl isothiocyanate, morantel tartrate, nemadectin, etc. 
     (14) Others 
     Viral agents such as nuclear polyhedrosis virus (NPV), granulosis virus (GV), cytoplasmic polyhedrosis virus (CPV) and entomopoxvirus (EPV); live spores derived from and crystal toxins produced from Bacillus thuringiesis, and a mixture thereof; microbial pesticides, insect pheromones, and insect attractants, which are utilized as insecticides or nematicides, such as Steinernema carpocapsae and Pasteuria penetrans; etc. 
     The agricultural/horticultural pest control agent containing the compound of the present invention as an active ingredient can be used by a method usually employed for pest control agents. Specifically, in the case of wettable powder, liquid formulation, emulsifiable concentrate, sol (flowable formulation), granular wettable powder or oil solution, a liquid is prepared by diluting the pest control agent from 50 to 10,000 times with water to afford an active ingredient concentration of generally from 1 to 10,000 ppm, preferably from 1 to 1,000 ppm, and the resulting dilute solution may be sprayed on the foliage in the diseased region of the plant in the range of 50 to 1,000 L, usually from 100 to 600 L, per 10 a of cropland, though this may vary depending on the crop shape such as paddy rice or fruit tree. 
     Alternatively, the pest control agent may be applied to agricultural/horticultural pests by aerial spraying in which a chemical solution after dilution with water to afford a predetermined active ingredient concentration is sprayed from a helicopter (including an RC helicopter). 
     In the case of dust, coarse particle, DL dust, flow dust, microgranule, fine granule or granule, from 0.3 to 50 kg/10 a (active ingredient content: approximately from 5 to 500 g) of the pest control agent may be applied to foliage in the region where pests appeared, soil surface, under soil surface or water surface. 
     In growing seedlings of, for example, paddy rice in a nursery box, a granule, etc. may be applied to soil surface or under soil surface before sowing or between after sowing and on the day of transplanting, in an amount of 10 to 100 g and in the case of a flowable formulation, etc., directly without dilution or after dilution, in an amount of 30 to 1,000 mL, per the nursery box (standard size: 30 cm×60 cm×5 cm). 
     EXAMPLES 
     The present invention is described more specifically below by referring to Synthesis Examples, Formulation Examples and Test Examples of the 1,2,3-triazole derivative, but the present invention is not limited thereto. 
     Synthesis Example 1 
     (1) Synthesis of 2-[3,5-bis(trifluoromethyl)phenyl]ethynyltrimethylsilane 
     In a nitrogen atmosphere, palladium(II) chloride (2.4 g, 13.7 mmol), triphenylphosphine (7.2 g, 27. 3 mmol) and copper(I) iodide (4.2 g, 21.8 mmol) were sequentially added to a triethylamine (270 mL) solution of 3,5-bis(trifluoromethyl)bromobenzene (80.0 g, 273.0 mmol), and trimethylsilylacetylene (32.2 g, 327.6 mmol) was added dropwise under ice cooling. After the completion of dropwise addition, the solution was stirred at room temperature overnight and filtered through Celite, and the filtrate was concentrated under reduced pressure. Subsequently, aqueous ammonia (30 mL) and water were added, and the resulting solution was extracted with hexane. The organic layer was washed with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (eluting solvent:hexane) to afford the title compound (83.1 g, yield: 98%) as an orange oily product. 
       1 HNMR Spectrum (CDCl 3 )σ: 7.88 (2H, s), 7.79 (1H, s), 0.27 (9H, s). 
     (2) Synthesis of 1-ethynyl-3,5-bis(trifluoromethyl)benzene 
     To a methanol (70 mL) and chloroform (70 mL) solution of 2-[3,5-bis(trifluoromethyl)phenyl]ethynyltrimethylsilane (83.1 g, 267.7 mmol), potassium carbonate (7.4 g, 53.5 mmol) was added, followed by stirring at room temperature overnight. After distilling off the solvent under reduced pressure, water was added to the solution, and the resulting solution was extracted with diethyl ether. The organic layer was washed with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure, and the crude product was purified by distillation under reduced pressure (82° C., 100 mbar) to afford the title compound (48.7 g, yield: 76%) as a colorless oily product. 
       1 HNMR Spectrum (CDCl 3 )σ: 7.92 (2H, s), 7.84 (1H, s), 3.26 (1H, s). 
     (3) Synthesis of 2-ethyl sulfanylaniline 
     To a methanol (25 mL) solution of 2-aminothiophenol (15.0 g, 119.8 mmol), a 28% sodium methoxide-methanol solution (27.7 g, 143.8 mmol) was added, and a methanol (15 mL) solution of iodoethane (18.7 g, 119.8 mmol) was added dropwise under heating at reflux. After the completion of dropwise addition, the solution was heated at reflux for 6 hours and allowed to cool to room temperature, and the solvent was then distilled off. Water was added to the obtained reaction solution, and the resulting solution was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (eluting solvent:ethyl acetate/hexane=1:20) to afford the title compound (yielded 17.8 g, yield: 97%) as an orange-tan oily product. 
       1 HNMR Spectrum (CDCl 3 )σ: 7.37 (1H, dd, J1=7.6 Hz, J2=1.6 Hz), 7.11 (1H, td, J1=7.7 Hz, J2=1.8 Hz), 6.73 (1H, dd, J1=8.0 Hz, J2=1.1 Hz), 6.69 (1H, td, J1=7.6 Hz, J2=1.4 Hz), 4.34 (2H, br), 2.76 (2H, q, J=7.3 Hz), 1.23 (3H, t, J=7.3 Hz). 
     (4) Synthesis of 1-azido-2-ethyl sulfanylbenzene 
     A 35% hydrochloric acid (30 mL) and water (30 mL) mixed solution of 2-ethylsulfanylaniline (17.8 g, 115.8 mmol) was cooled to −5° C., and an aqueous sodium nitrite (9.6 g, 139.0 mmol) solution (35 mL) was added dropwise. After the completion of dropwise addition, the resulting solution was stirred at −5° C. for 30 minutes and subsequently, an aqueous sodium azide (11.3 g, 173.7 mmol) solution (40 mL) was added dropwise. The resulting solution was stirred at −5° C. for 60 minutes and at room temperature for 4 hours. The reaction solution was extracted by adding ethyl acetate, and the organic layer was washed with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure. The obtained crude product was purified by silica gel column chromatography (eluting solvent:ethyl acetate/hexane=1:20) to afford the title compound (19.3 g, yield: 93%) as a yellow oily product. 
       1 HNMR Spectrum (CDCl 3 )σ: 7.30 (1H, dd, J1=7.8 Hz, J2=1.4 Hz), 7.24-7.22 (1H, m), 7.14 (1H, dd, J1=7.8 Hz, J2=0.9 Hz), 7.10 (1H, td, J1=7.6 Hz, J2=1.4 Hz), 2.94 (2H, q, J=7.3 Hz), 1.32 (3H, t, J=7.3 Hz). 
     (5) Synthesis of 4-[3,5-bis(trifluoromethyl)phenyl]-1-(2-ethylsulfanylphenyl)triazole (1-75) 
     To a tert-butanol (36 mL) and water (18 mL) mixed solution of 1-azido-2-ethyl sulfanylbenzene (4.5 g, 25.2 mmol), 1-ethynyl-3,5-bis(trifluoromethyl)benzene (6.0 g, 25.2 mmol), anhydrous copper(II) sulfate (603 mg, 3.8 mmol), and sodium L-ascorbate (2.0 g, 10.1 mmol) were sequentially added, followed by stirring at room temperature overnight. Water was added to the obtained reaction solution, and the resulting solution was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (eluting solvent:ethyl acetate/hexane=1:4) to afford the title compound (yielded 10.1 g, yield: 96%) as a yellow solid. 
       1 HNMR Spectrum (CDCl 3 )σ: 8.39 (2H, s), 8.31 (1H, s), 7.86 (1H, s), 7.57-7.49 (3H, m), 7.40 (1H, td, J1=7.6 Hz, J2=1.7 Hz), 2.84 (2H, q, J=7.5 Hz), 1.25 (3H, t, J=7.3 Hz). 
     (6) Synthesis of 4-[3,5-bis(trifluoromethyl)phenyl]-1-(2-ethylsulfinylphenyl)triazole (1-354) 
     To a chloroform (3 mL) solution of 4-[3,5-bis(trifluoromethyl)phenyl]-1-(2-ethylsulfanylphenyl)triazole (350.0 mg, 0.84 mmol), 77% metachloroperbenzoic acid (188.0 mg, 0.84 mmol) was added under ice cooling, followed by stirring under ice cooling for 2 hours. An aqueous saturated sodium hydrogencarbonate solution was poured in the reaction solution, and the resulting solution was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (eluting solvent:ethyl acetate/hexane=1:1) to afford the title compound (yielded 350.2 mg, yield: 96%) as a white solid. 
       1 HNMR Spectrum (CDCl 3 )σ: 8.38 (2H, br), 8.34 (1H, s), 8.27 (1H, dd, J1=8.0 Hz, J2=1.6 Hz), 7.91 (1H, br), 7.80 (1H, td, J1=7.7 Hz, J2=1.2 Hz), 7.71 (1H, td, J1=7.7 Hz, J2=1.5 Hz), 7.56 (1H, dd, J1=7.8 Hz, J2=0.9 Hz), 3.36-3.28 (1H, m), 2.97-2.88 (1H, m), 1.37 (3H, t, J=7.3 Hz). 
     (7) Synthesis of 4-[3,5-bis(trifluoromethyl)phenyl]-1-(2-ethylsulfonylphenyl)triazole (1-631) 
     To a chloroform (3 mL) solution of 4-[3,5-bis(trifluoromethyl)phenyl]-1-(2-ethylsulfanylphenyl)triazole (350.0 mg, 0.84 mmol), 77% metachloroperbenzoic acid (385.3 mg, 1.7 mmol) was added under ice cooling, followed by stirring under ice cooling for 2 hours. An aqueous saturated sodium hydrogencarbonate solution was poured in the reaction solution, and the resulting solution was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (eluting solvent:ethyl acetate/hexane=1:1) to afford the title compound (yielded 363.1 mg, yield: 96%) as a white solid. 
       1 HNMR Spectrum (CDCl 3 )σ: 8.37 (2H, s), 8.34 (1H, s), 8.29 (1H, dd, J1=7.6 Hz, J2=1.6 Hz), 7.88-7.83 (3H, m), 7.58 (1H, dd, J1=7.3 Hz, J2=1.8 Hz), 3.21 (2H, q, J=7.5 Hz), 1.26 (3H, t, J=7.3 Hz). 
     Synthesis Example 2 
     (1) Synthesis of trimethyl-[2-[4-(trifluoromethyl)-2-pyridyl]ethynyl]silane 
     In a nitrogen atmosphere, palladium(II) chloride (3.17 g, 17.9 mmol), triphenylphosphine (9.4 g, 35.8 mmol) and copper(I) iodide (5.5 g, 28.6 mmol) were sequentially added to a triethylamine (320 mL) solution of 2-chloro-4-(trifluoromethyl)pyridine (65.0 g, 358.0 mmol), and trimethylsilylacetylene (42.2 g, 429.7 mmol) was added dropwise under ice cooling. After the completion of dropwise addition, the solution was stirred at 80° C. for 8 hours and filtered through Celite, and the filtrate was concentrated under reduced pressure. Subsequently, aqueous ammonia (30 mL) and water were added, and the resulting solution was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (eluting solvent:ethyl acetate/hexane=1:20) to afford the title compound (82.2 g, yield: 94.4%) as an orange oily product. 
       1 HNMR Spectrum (CDCl 3 )σ: 8.75 (1H, d, J=5.0 Hz), 7.67 (1H, s), 7.44 (1H, dd, J1=5.0 Hz, J2=0.9 Hz), 0.29 (9H, s). 
     (2) Synthesis of 2-ethynyl-4-(trifluoromethyl)pyridine 
     To a methanol (200 mL) and chloroform (200 mL) solution of trimethyl-[2-[4-(trifluoromethyl)-2-pyridyl]ethynyl]silane (82.2 g, 337.9 mmol), potassium carbonate (2.3 g, 16.9 mmol) was added, followed by stirring at room temperature for 1 hour. After distilling off the solvent under reduced pressure, water was added to the solution, and the resulting solution was extracted with diethyl ether. The organic layer was washed with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure, and the crude product was purified by silica gel column chromatography (eluting solvent:ethyl acetate/hexane=1:10) to afford the title compound (45.8 g, yield: 79%) as a colorless oily product. 
       1 HNMR Spectrum (CDCl 3 )σ: 8.79 (1H, d, J=5.0 Hz), 7.70 (1H, s), 7.49 (1H, dd, J1=5.0 Hz, J2=0.9 Hz), 3.27 (1H, s). 
     (3) Synthesis of 2-chloro-4-(pentafluoro-λ 6 -sulfanyl)aniline 
     An acetonitrile solution (24 mL) of 4-aminophenylsulfur pentafluoride (6.00 g, 27.4 mmol) was heated at 60° C., and N-chlorosuccinimide (4.02 g, 30.1 mmol) was added, followed by stirring under heating at reflux for 3 hours. The resulting solution was allowed to cool to room temperature, and the solvent was then distilled off under reduced pressure. To the obtained residue, 30 mL of an aqueous 5% sodium hydroxide solution was added, and the resulting solution was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (eluting solvent:ethyl acetate/hexane=1:7) to afford the title compound (yielded 6.40 g, yield: 92%) as a red-tan oily product. 
       1 HNMR Spectrum (CDCl 3 )σ: 7.66 (1H, d, J=2.7 Hz), 7.45 (1H, dd, J1=8.9 Hz, J2=2.5 Hz), 6.72 (1H, d, J=9.2 Hz), 4.42 (2H, br). 
     (4) Synthesis of (4-azido-3-chloro-phenyl)-pentafluoro-λ 6 -sulfane 
     A 35% hydrochloric acid (30 mL) and water (30 mL) mixed solution of 2-chloro-4-(pentafluoro-λ 6 -sulfanyl)aniline (6.40 g, 25.2 mmol) was cooled to −5° C., and an aqueous sodium nitrite (2.09 g, 30.3 mmol) solution (15 mL) was added dropwise. After the completion of dropwise addition, the resulting solution was stirred at −5° C. for 30 minutes and subsequently, an aqueous sodium azide (2.13 g, 32.8 mmol) solution (15 mL) was added dropwise. The resulting solution was stirred at −5° C. for 60 minutes and at room temperature for 4 hours. The reaction solution was extracted by adding ethyl acetate, and the organic layer was washed with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure. The obtained crude product was purified by silica gel column chromatography (eluting solvent:ethyl acetate/hexane=1:20) to afford the title compound (4.50 g, yield: 64%) as an orange oily product. 
       1 HNMR Spectrum (CDCl 3 )σ: 7.80 (1H, d, J=2.3 Hz), 7.68 (1H, dd, J1=8.9 Hz, J2=2.5 Hz), 7.23 (1H, d, J=8.7 Hz). 
     (5) Synthesis of [3-chloro-4-[4-[4-(trifluoromethyl)-2-pyridyl]triazol-1-yl]phenyl]-pentafluoro-λ 6 -sulfane 
     To an N,N′-dimethylformamide (4 mL) and water (1 mL) mixed solution of (4-azido-3-chloro-phenyl)-pentafluoro-λ 6 -sulfane (490.2 mg, 1.8 mmol), 2-ethynyl-4-(trifluoromethyl)pyridine (300.0 mg, 1.8 mmol), anhydrous copper(II) sulfate (42.0 mg, 0.3 mmol), and sodium L-ascorbate (138.9 g, 0.70 mmol) were sequentially added, followed by stirring at room temperature overnight. Water was added to the obtained reaction solution, and the resulting solution was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (eluting solvent:ethyl acetate/hexane=1:6) to afford the title compound (yielded 690.1 mg, yield: 87%) as a yellow solid. 
       1 HNMR Spectrum (CDCl 3 )σ: 8.81 (1H, d, J=5.0 Hz), 8.74 (1H, s), 8.51 (1H, s), 8.06 (1H, s), 7.91 (2H, s), 7.51 (1H, d, J=5.0 Hz). 
     (6) Synthesis of 3-ethynylsulfanyl-4-[4-[4-(trifluoromethyl)-2-pyridyl]triazol-1-yl]phenyl]-pentafluoro-λ 6 -sulfane (2-118) 
     An N,N′-dimethylformamide solution (5 mL) of 60% sodium hydride (71.4 mg, 1.8 mmol) was cooled on ice, and ethanethiol (110.8 mg, 1.8 mmol) was added dropwise thereto, followed by stirring for 10 minutes. Subsequently, [3-chloro-4-[4-[4-(trifluoromethyl)-2-pyridyl]triazol-1-yl]phenyl]-pentafluoro-λ 6 -sulfane (618.5 mg, 1.4 mmol) was added under ice cooling, followed by stirring at room temperature for 2 hours. Water was added to the reaction solution, and the resulting solution was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (eluting solvent:ethyl acetate/hexane=1:6) to afford the title compound (419.1 mg, yield: 64%) as a red solid. 
       1 HNMR Spectrum (CDCl 3 )σ: 8.81 (1H, d, J=5.0 Hz), 8.63 (1H, s), 8.51 (1H, s), 7.87 (1H, d, J=2.3 Hz), 7.76 (1H, dd, J1=8.7 Hz, J2=2.3 Hz), 7.67 (1H, d, J=8.7 Hz), 7.49 (1H, d, J=4.1 Hz), 2.93 (2H, q, J=7.3 Hz), 1.29 (3H, t, J=7.3 Hz). 
     (7) Synthesis of [3-ethyl sulfonyl-4-[4-[4-(trifluoromethyl)-2-pyridyl]triazol-1-yl]phenyl]-pentafluoro-λ 6 -sulfane (2-398) 
     To a chloroform (3 mL) solution of [3-ethylsulfanyl-4-[4-[4-(trifluoromethyl)-2-pyridyl]triazol-1-yl]phenyl]-pentafluoro-λ 6 -sulfane (974.0 mg, 2.0 mmol), 77% metachloroperbenzoic acid (939.3 mg, 4.2 mmol) was added under ice cooling, followed by stirring under ice cooling overnight. An aqueous saturated sodium hydrogencarbonate solution was poured in the reaction solution, and the resulting solution was extracted with chloroform. The organic layer was washed with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (eluting solvent:ethyl acetate/hexane=1:1) to afford the title compound (yielded 490.0 mg, yield: 47%) as a white solid. 
       1 HNMR Spectrum (CDCl 3 )σ: 8.81 (1H, d, J=5.0 Hz), 8.66 (1H, d, J=2.7 Hz), 8.60 (1H, s), 8.48 (1H, s), 8.24 (1H, dd, J1=8.7 Hz, J2=2.7 Hz), 7.72 (1H, d, J=8.7 Hz), 7.51 (1H, d, J=6.0 Hz), 3.39 (2H, q, J=7.5 Hz), 1.33 (3H, t, J=7.3 Hz). [0205] 
     Synthesis Example 3 
     (1) Synthesis of 2-(1H-triazol-4-yl)-4-(trifluoromethyl)pyridine 
     In a nitrogen atmosphere, copper(I) iodide (223.0 mg, 1.2 mmol) and azidotrimethylsilane (4.0 g, 35.1 mmol) were sequentially added to an N,N′-dimethylformamide (9 mL) and methanol (1 mL) mixed solution of 2-ethynyl-4-(trifluoromethyl)pyridine (4.0 g, 23.4 mmol), followed by stirring at 100° C. for 7 hours. The resulting solution was allowed to cool to room temperature and filtered through Celite, and the filtrate was concentrated under reduced pressure. Subsequently, the obtained crude product was purified by silica gel column chromatography (eluting solvent:ethyl acetate/hexane=2:1) to afford the title compound (yielded 2.0 g, yield: 40%) as a brown solid. 
       1 HNMR Spectrum (CDCl 3 )σ: 8.83 (1H, d, J=5.0 Hz), 8.36 (1H, s), 8.27 (1H, br), 7.50 (1H, d, J=4.6 Hz). 
     (2) Synthesis of 3-ethynylsulfonyl-5-(trifluoromethyl)-2-[4-[4-(trifluoromethyl)-2-pyridyl]triazol-1-yl]pyridine (2-387) 
     To an N,N′-dimethylformamide (3 mL) solution of 2-(1H-triazol-4-yl)-4-(trifluoromethyl)pyridine (200.0 mg, 0.9 mmol), potassium carbonate (193.6 mg, 1.4 mmol) and 2,3-bis(ethylsulfonyl)-5-(trifluoromethyl)pyridine (464.1 mg, 1.4 mmol, synthesized by reference to International Publication No. 2016/020286) were sequentially added, followed by stirring at room temperature overnight. Water was added to the solution, and the resulting solution was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure, and the crude product was purified by silica gel column chromatography (eluting solvent:ethyl acetate/hexane=1:6) to afford the title compound (105.0 mg, yield: 25%) as a white solid. 
       1 HNMR Spectrum (CDCl 3 )σ: 9.14 (1H, m), 8.90-8.87 (2H, m), 8.62 (1H, s), 8.32 (1H, s), 7.57 (1H, dd, J1=5.0 Hz, J2=0.9 Hz), 3.99 (2H, q, J=7.5 Hz), 1.50 (3H, t, J=7.6 Hz). 
     Synthesis Example 4 
     Synthesis of 1-(2-ethylsulfanylphenyl)-4-[3-(trifluoromethyl)phenyl]triazole (1-26) 
     To a dimethylsulfoxide (4 mL) solution of 3′-(trifluoromethyl)acetophenone (400 mg, 2.1 mmol), 2-ethylsulfanylaniline (390.9 mg, 2.6 mmol), 4-methylbenzene sulfonhydrazide (593.9 mg, 3.2 mmol), and iodine (809.4 mg, 3.2 mmol) were sequentially added, followed by stirring at 100° C. for 6 hours. Water was poured in the reaction solution, and the resulting solution was extracted with ethyl acetate. The organic layer was washed with an aqueous 10% sodium thiosulfate solution and then with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (eluting solvent:ethyl acetate/hexane=1:6) to afford the title compound (yielded 315.5 mg, yield: 42%) as a tan oily product. 
       1 HNMR Spectrum (CDCl 3 )σ: 8.24 (1H, s), 8.18 (1H, s), 8.14 (1H, d, J=7.3 Hz), 7.64-7.59 (2H, m), 7.55-7.47 (3H, m), 7.39 (1H, td, J1=7.4 Hz, J2=1.5 Hz), 2.83 (2H, q, J=7.3 Hz), 1.24 (3H, t, J=7.3 Hz). 
     Synthesis Example 5 
     Synthesis of 1-(2-ethylsulfanylphenyl)-5-methyl-4-[3-(trifluoromethyl)phenyl]triazole (1-27) 
     To a methanol (3 mL) solution of 4-methylbenzene sulfonhydrazide (460.6 mg, 2.5 mmol), 3′-(trifluoromethyl)propiophenone (500 mg, 2.5 mmol) was sequentially added, followed by stirring at room temperature for 10 minutes. The solvent was distilled off under reduced pressure, and to the obtained white solid, toluene (5 mL), copper(II) acetate (449.2 mg, 2.5 mmol), pivalic acid (505.2 mg, 4.9 mmol), and 2-ethylsulfanylaniline (758.0 mg, 4.9 mmol) were sequentially added, followed by stirring at 110° C. for 8 hours. The solvent was concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (eluting solvent:ethyl acetate/hexane=1:6) to afford the title compound (yielded 383.5 mg, yield: 43%) as a red-tan oily product. 
       1 HNMR Spectrum (CDCl 3 )σ: 8.11 (1H, s), 8.05 (1H, dt, J1=4.5 Hz, J2=2.4 Hz), 7.65-7.61 (2H, m), 7.54-7.51 (2H, m), 7.41-7.35 (1H, m), 2.85 (2H, q, J=7.3 Hz), 1.25 (3H, t, J=7.6 Hz). 
     Synthesis Example 6 
     Synthesis of 5-[3,5-bis(trifluoromethyl)phenyl]-3-(2-ethylsulfanylphenyl)triazole-4-amine (1-82) 
     An ethanol (10 mL) solution of 3,5-bis(trifluoromethyl)phenylacetonitrile (3.59 g, 14.2 mmol) and 2-ethylsulfanylaniline (2.54 g, 14.2 mmol) was cooled on ice, and an ethanol (10 mL) solution of sodium methoxide (1.2 g, 21.3 mmol) was sequentially added dropwise, followed by stirring under ice cooling for 72 hours. Water was poured in the reaction solution, and the resulting solution was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over sodium sulfate, filtered to remove the white precipitate, and concentrated under reduced pressure, and the obtained crude product was purified by silica gel column chromatography (eluting solvent:ethyl acetate/hexane=1:6) to afford the title compound (yielded 5.3 g, yield: 87%) as a red-tan oily product. 
       1 HNMR Spectrum (CDCl 3 )σ: 8.29 (2H, s), 7.79 (1H, s), 7.58-7.52 (2H, m), 7.44-7.39 (2H, m), 4.00 (2H, br), 2.87 (2H, q, J=7.3 Hz), 1.27 (3H, t, J=7.3 Hz). 
     The values of  1 HNMR spectrum (CDCl 3 ) and σ (ppm) of each of the compounds according to the present invention synthesized based on the synthesis examples and production examples above are shown in Table 5. The  1 HNMR data was measured by JNM-ECS400 Spectrometer (manufactured by JEOL Ltd.). 
                         TABLE 5               Compound           No.     1 H-NMR Spectrum (CDCl 3 ) σ ppm:                  1-16   8.18 (1H, s), 7.95-7.93 (2H, m), 7.54 (2H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.50-7.45 (3H, m),           7.40-7.35 (2H, m), 2.81 (2H, q, J = 7.3 Hz), 1.23 (3H, t, J = 7.3 Hz).       1-21   8.18 (1H, s), 7.93 (1H, t, J = 1.8 Hz), 7.82 (1H, dt, J1 = 7.3 Hz, J2 = 1.4 Hz), 7.55-7.52 (2H,           m), 7.48 (1H, td, J1 = 7.7 Hz, J2 = 1.5 Hz), 7.42-7.32 (3H, m), 2.81 (2H, q, J = 7.3 Hz), 1.23           (3H, t, J = 7.3 Hz).       1-22   8.16 (1H, s), 7.87 (2H, d, J = 7.3 Hz), 7.54-7.36 (6H, m), 2.82 (2H, q, J = 7.3 Hz), 1.23 (3H, t,           J = 7.3 Hz).       1-23   8.18 (1H, s), 8.08 (1H, t, J = 1.8 Hz), 7.87 (1H, dt, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.55-7.51 (2H,           m), 7.50-7.46 (2H, m), 7.38 (1H, td, J1 = 7.6 Hz, J2 = 1.7 Hz), 7.35 (2H, m), 2.81 (2H, q,           J = 7.3 Hz), 1.23 (3H, t, J = 7.3 Hz).       1-24   8.20 (1H, s), 7.86 (1H, dt, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.81 (1H, s), 7.53 (2H, td, J1 = 7.3 Hz,           J2 = 1.4 Hz), 7.49 (2H, t, J = 8.2 Hz), 7.38 (1H, td, J1 = 7.6 Hz, J2 = 1.7 Hz), 7.22 (1H, dt,           J1 = 8.2 Hz, J2 = 1.1 Hz), 2.82 (2H, q, J = 7.3 Hz), 1.23 (3H, t, J = 7.3 Hz).       1-25   8.23 (1H, s), 8.12 (1H, d, J = 7.3 Hz), 7.80 (1H, d, J = 7.8 Hz), 7.69 (1H, t, J = 7.6 Hz), 7.57-           7.47 (4H, m), 7.39 (1H, d, J = 7.6 Hz), 2.79 (2H, q, J = 7.2 Hz), 1.23 (3H, t, J = 7.3 Hz).       1-26   8.24 (1H, s), 8.18 (1H, s), 8.14 (1H, d, J = 7.3 Hz), 7.64-7.59 (2H, m), 7.55-7.47 (3H, m),           7.39 (1H, td, J1 = 7.4 Hz, J2 = 1.5 Hz), 2.83 (2H, q, J = 7.3 Hz), 1.24 (3H, t, J = 7.3 Hz).       1-27   8.11 (1H, s), 8.05 (1H, dt, J1 = 4.5 Hz, J2 = 2.4 Hz), 7.65-7.61 (2H, m), 7.54-7.51 (2H, m),           7.41-7.35 (1H, m), 2.85 (2H, q, J = 7.3 Hz), 1.25 (3H, t, J = 7.6 Hz).       1-28   8.11 (1H, s), 8.02 (1H, dt, J1 = 7.3 Hz, J2 = 1.6 Hz), 7.63-7.60 (2H, m), 7.54-7.50 (2H, m),           7.38-7.37 (2H, m), 2.87 (2H, q, J = 7.3 Hz), 2.78 (2H, q, J = 7.8 Hz), 1.26 (3H, t, J = 7.3 Hz),           1.08 (3H, t, J = 7.8 Hz).       1-29   8.39 (1H, s), 8.30 (1H, d, J = 7.3 Hz), 7.68-7.61 (2H, m), 7.58-7.57 (2H, m), 7.42-7.39 (2H,           m), 2.89 (2H, q, J = 7.3 Hz), 1.25 (3H, t, J = 7.3 Hz).       1-31   8.41 (1H, s), 8.31 (1H, d, J = 7.8 Hz), 7.69-7.61 (2H, m), 7.57 (2H, d, J = 3.7 Hz), 7.43-7.39           (1H, m), 7.35 (1H, d, J = 8.2 Hz), 2.90 (2H, q, J = 7.3 Hz), 1.27 (3H, t, J = 7.3 Hz).       1-38   8.24 (1H, s), 8.17-8.13 (2H, m), 7.78 (1H, d, J = 1.8 Hz), 7.75-7.72 (1H, m), 7.65-7.56 (3H,           m), 2.96 (2H, q, J = 7.5 Hz), 1.33 (3H, t, J = 7.3 Hz).       1-40   8.25 (1H, s), 8.05 (2H, d, J = 8.2 Hz), 7.72 (2H, d, J = 8.2 Hz), 7.56-7.48 (3H, m), 7.39 (1H, t,           J = 7.6 Hz), 2.82 (2H, q, J = 7.2 Hz), 1.23 (3H, t, J = 7.3 Hz).       1-53   8.16 (1H, s), 7.87 (1H, d, J = 8.2 Hz), 7.55-7.45 (5H, m), 7.37 (1H, td, J1 = 7.6 Hz, J2 = 1.4           Hz), 2.78 (2H, q, J = 7.3 Hz), 1.22 (3H, t, J = 7.3 Hz).       1-54   8.22 (1H, s), 8.01 (2H, dt, J1 = 8.4 Hz, J2 = 1.9 Hz), 7.71 (2H, dt, J1 = 8.5 Hz, J2 = 1.9 Hz),           7.67-7.65 (2H, m), 7.50-7.45 (3H, m), 7.41-7.35 (2H, m), 2.81 (2H, q, J = 7.3 Hz), 1.24 (3H,           t, J = 7.3 Hz).       1-55   8.13 (1H, s), 7.90 (2H, dt, J1 = 9.5 Hz, J2 = 2.5 Hz), 7.53 (2H, d, J = 2.5 Hz), 7.47 (1H, td,           J1 = 7.6 Hz, J2 = 1.7 Hz), 7.40-7.34 (3H, m), 7.16-7.05 (5H, m), 2.81 (2H, q, J = 7.3 Hz), 1.23           (3H, t, J = 7.6 Hz).       1-56   8.27 (1H, s), 8.05 (2H, dt, J1 = 8.4 Hz, J2 = 1.6 Hz), 7.76 (2H, dt, J1 = 8.4 Hz, J2 = 1.8 Hz),           7.56-7.48 (3H, m), 7.39 (1H, td, J1 = 7.3 Hz, J2 = 1.7 Hz), 2.83 (2H, q, J = 7.5 Hz), 1.24 (3H,           t, J = 7.6 Hz).       1-57   8.69 (1H, s), 8.55 (1H, d, J = 8.2 Hz), 7.76 (1H, s), 7.67 (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz),           7.56 (2H, d, J = 7.8 Hz), 7.50 (1H, td, J1 = 7.3 Hz, J2 = 1.2 Hz), 7.40 (1H, td, J1 = 7.6 Hz,           J2 = 1.1 Hz), 2.83 (2H, q, J = 7.5 Hz), 1.24 (3H, t, J = 7.8 Hz).       1-75   8.39 (2H, s), 8.31 (1H, s), 7.86 (1H, s), 7.57-7.49 (3H, m), 7.40 (1H, td, J1 = 7.6 Hz, J2 = 1.7           Hz), 2.84 (2H, q, J = 7.5 Hz), 1.25 (3H, t, J = 7.3 Hz).       1-81   8.64 (2H, s), 7.93 (1H, s), 7.59-7.56 (2H, m), 7.44-7.40 (1H, m), 7.36-7.34 (1H, m), 2.91           (2H, q, J = 7.3 Hz), 1.27 (3H, t, J = 7.3 Hz).       1-82   8.29 (2H, s), 7.79 (1H, s), 7.58-7.52 (2H, m), 7.44-7.39 (2H, m), 4.00 (2H, br), 2.87 (2H, q,           J = 7.3 Hz), 1.27 (3H, t, J = 7.3 Hz).       1-83   8.52 (1H, s), 7.96 (1H, s), 7.56-7.54 (2H, m), 7.44-7.42 (2H, m), 4.19 (2H, q, J = 7.2 Hz),           2.80 (2H, q, J = 7.3 Hz), 1.21 (3H, t, J = 7.3 Hz), 1.05 (3H, t, J = 7.1 Hz).       1-84   8.63 (2H, s), 8.01 (1H, s), 7.64-7.63 (2H, m), 7.49-7.46 (2H, m), 2.93 (2H, q, J = 7.3 Hz),           1.28 (3H, t, J = 7.3 Hz).       1-85   8.38 (2H, s), 8.34 (1H, s), 7.87 (1H, s), 7.70 (1H, dd, J1 = 7.8 Hz, J2 = 0.9 Hz), 7.53 (1H, dd,           J1 = 7.8 Hz, J2 = 1.4 Hz), 7.50-7.46 (1H, m), 2.67 (2H, q, J = 7.3 Hz), 1.05 (3H, t, J = 7.3 Hz).       1-86   8.37 (2H, s), 8.28 (1H, s), 7.87 (1H, s), 7.47-7.45 (2H, m), 7.35 (1H, dd, J1 = 8.7 Hz, J2 = 2.3           Hz), 2.89 (2H, q, J = 7.3 Hz), 1.29 (3H, t, J = 7.6 Hz).       1-87   8.38 (2H, s), 8.33 (1H, s), 7.88 (1H, s), 7.58 (1H, t, J = 1.1 Hz), 7.49 (2H, d, J = 1.4 Hz), 2.82           (2H, q, J = 7.3 Hz), 1.24 (3H, t, J = 7.3 Hz).       1-88   8.41 (2H, s), 8.09 (1H, s), 7.87 (1H, s), 7.49-7.42 (2H, m), 7.39 (1H, td, J1 = 8.5 Hz, J2 = 3.1           Hz), 2.90 (2H, q, J = 7.3 Hz), 1.28 (3H, t, J = 7.3 Hz).       1-90   8.38 (2H, s), 8.36 (1H, s), 7.88 (1H, s), 7.75 (1H, s), 7.68 (1H, d, J = 8.2 Hz), 7.64 (1H, dd,           J1 = 8.2 Hz, J = 1.8 Hz), 2.94 (2H, q, J = 7.5 Hz), 1.30 (3H, t, J = 7.6 Hz).       1-91   8.38 (1H, br), 8.32 (1H, s), 7.88 (1H, br), 7.77 (1H, s), 7.75 (1H, d, J = 8.7 Hz), 7.58 (1H, d,           J = 8.2 Hz), 2.98 (2H, q, J = 7.5 Hz), 1.33 (3H, t, J = 7.6 Hz).       1-197   8.27 (1H, s), 8.24 (1H, s), 8.11 (1H, s), 7.74 (1H, s), 7.55-7.46 (3H, m), 7.40-7.35 (1H, m),           2.82 (2H, q, J = 7, 3 Hz), 1.23 (3H, t, J = 7.3 Hz).       1-210   8.70 (1H, s), 8.47 (1H, s), 8.32 (1H, s), 8.28 (1H, s), 7.56-7.48 (3H, m), 7.39 (1H, td,           J1 = 7.6 Hz, J2 = 1.5 Hz), 4.00 (3H, s), 2.84 (2H, q, J = 7.3 Hz), 1.24 (3H, t, J = 7.3 Hz).       1-227   8.63 (1H, s), 8.33 (2H, s), 8.15 (1H, s), 8.00 (1H, br), 7.70 (2H, d, J = 7.8 Hz), 7.57-7.49           (3H, m), 7.44-7.38 (3H, m), 7.23-7.19 (1H, m), 2.85 (2H, q, J = 7.3 Hz), 1.25 (3H, t, J = 7.6           Hz).       1-228   8.62 (1H, s), 8.32 (1H, s), 8.29 (1H, s), 8.14 (1H, s), 8.12 (1H, br), 7.69-7.65 (2H, m), 7.57-           7.50 (3H, m), 7.42-7.36 (3H, m), 2.86 (2H, q, J = 7.5 Hz), 1.25 (3H, t, J = 7.3 Hz).       1-229   8.40 (1H, s), 8.38 (2H, s), 7.88 (1H, s), 7.61 (1H, dd, J = 8.7, 5.5 Hz), 7.38 (1H, dd, J = 8.2,           2.7 Hz), 2.74 (2H, q, J = 7.3 Hz), 1.18 (3H, t, J = 7.3 Hz).       1-230   8.38 (2H, s), 8.32 (1H, s), 7.86 (1H, s), 7.48 (1H, d, J = 8.2 Hz), 7.38 (1H, d, J = 1.8 Hz), 7.32           (1H, dd, J = 8.5, 1.6 Hz), 2.75 (2H, q, J = 7.3 Hz), 1.19 (1H, t, J = 7.3 Hz).       1-231   8.40 (1H, s), 8.38 (2H, s), 7.87 (1H, s), 7.59 (1H, d, J = 8.7 Hz), 7.15 (1H, d, J = 2.7 Hz), 7.06           (1H, dd, J = 8.7, 2.7 Hz), 3.88 (3H, s), 2.63 (2H, q, J = 7.3 Hz), 1.12 (3H, t, J = 7.6 Hz).       1-232   8.42 (2H, s), 8.31 (1H, s), 8.05 (1H, s), 7.84 (1H, s), 7.08 (1H, d, J = 0.9 Hz), 3.23 (2H, q,           J = 7.3 Hz), 1.49 (3H, t, J = 7.6 Hz).       1-233   8.25 (1H, s), 8.07 (1H, d, J = 8.7 Hz), 7.71 (1H, d, J = 8.2 Hz), 7.54 (1H, dt, J1 = 8.1 Hz,           J2 = 1.7 Hz), 7.49 (1H, td, J1 = 7.6 Hz, J2 = 1.5 Hz), 7.39 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz), 2.81           (2H, q, J = 7.3 Hz), 1.23 (3H, t, J = 7.3 Hz).       1-234   8.37 (1H, s), 8.34 (1H, s), 8.29 (1H, s), 7.88 (1H, s), 7.56-7.49 (3H, m), 7.39 (1H, td,           J1 = 7.4 Hz, J2 = 1.5 Hz), 6.48 (1H, br), 5.68 (1H, br), 2.84 (2H, q, J = 7.3 Hz), 1.24 (3H, t,           J = 7.3 Hz).       1-235   8.39 (2H, s), 7.87 (1H, s), 7.62-7.56 (2H, m), 7.49-7.42 (2H, m), 2.89 (2H, d, J = 7.3 Hz),           1.25 (3H, t, J = 7.3 Hz).       1-236   8.33 (1H, s), 8.24 (1H, s), 8.08 (1H, d, J = 7.8 Hz), 7.75 (1H, d, J = 8.2 Hz), 7.59-7.48 (4H,           m), 7.39 (1H, t, J = 7.6 Hz), 2.83 (2H, q, J = 7.5 Hz), 1.24 (3H, t, J = 7.3 Hz).       1-237   8.67 (1H, s), 8.41 (1H, s), 8.32 (1H, s), 8.19 (1H, s), 7.57-7.49 (3H, m), 7.40 (1H, td,           J1 = 7.4 Hz, J2 = 1.7 Hz), 2.85 (2H, q, J = 7.3 Hz), 2.73 (3H, s), 1.25 (3H, t, J = 7.6 Hz).       1-238   8.35 (1H, s), 8.33 (1H, s), 8.29 (1H, s), 7.86 (1H, s), 7.56-7.49 (3H, m), 7.39 (1H, td,           J1 = 7.6 Hz, J2 = 1.5 Hz), 6.58 (1H, br), 2.96 (3H, d, J = 5.0 Hz), 2.84 (2H, q, J = 7.3 Hz), 1.24           (3H, t, J = 7.3 Hz).       1-239   8.18 (1H, s), 7.82 (2H, d, J = 1.8 Hz), 7.55-7.46 (3H, m), 7.40-7.33 (2H, m), 2.81 (2H, q,           J = 7.3 Hz), 1.22 (3H, t, J = 7.3 Hz).       1-240   8.43 (2H, s), 8.34 (1H, s), 7.89 (1H, s), 7.57-7.51 (3H, m), 7.42-7.39 (1H, m), 2.85 (2H, q,           J = 7.3 Hz), 1.25 (3H, t, J = 7.3 Hz).       1-241   8.49 (2H, d, J = 6.9 Hz), 8.37 (1H, s), 8.01 (1H, s), 7.83 (2H, dd, J = 5.0, 3.2 Hz), 7.62 (1H, tt,           J1 = 7.3, J2 = 1.5 Hz), 7.53-7.44 (5H, m), 7.33 (1H, td, J1 = 7.6, J2 = 1.7 Hz), 2.83 (2H, q, J = 7.5           Hz), 1.22 (3H, t, J = 7.3 Hz).       1-242   8.41 (1H, s), 8.33-8.29 (3H, m), 7.93 (1H, s), 7.59 (2H, d, J = 7.8 Hz), 7.52-7.50 (3H, m),           7.39-7.33 (3H, m), 7.19 (1H, td, J1 = 7.3 Hz, J2 = 1.1 Hz), 2.83 (2H, q, J = 7.5 Hz), 1.23 (3H,           t, J = 7.3 Hz).       1-243   8.29 (1H, s), 8.27 (1H, s), 8.25 (1H, s), 7.75 (1H, s), 7.53-7.50 (3H, m), 7.38 (1H, td,           J1 = 7.4 Hz, J2 = 1.5 Hz), 2.84 (2H, q, J = 7.5 Hz), 2.01 (3H, t, J = 18.3 Hz), 1.24 (3H, t, J = 7.3           Hz).       1-244   8.66 (1H, s), 8.40 (1H, s), 8.28 (1H, s), 8.19 (1H, s), 7.88-7.85 (1H, m), 7.60-7.52 (3H, m),           5.92 (1H, dq, J1 = 55.3 Hz, J2 = 6.3 Hz), 2.73 (3H, s), 1.63 (3H, dd, J1 = 20.1 Hz, J2 = 6.4 Hz).       1-245   8.36 (1H, s), 8.28 (1H, s), 8.12 (1H, s), 7.82 (1H, s), 7.69-7.66 (2H, m), 7.56-7.46 (5H, m),           7.44-7.36 (2H, m), 2.82 (2H, q, J = 7.5 Hz), 1.23 (3H, t, J = 7.3 Hz).       1-246   8.21 (1H, s), 7.88 (2H, s), 7.55-7.47 (3H, m), 7.40-7.36 (1H, m), 7.31 (1H, s), 2.82 (2H, q,           J = 7.3 Hz), 1.23 (3H, t, J = 7.3 Hz).       1-247   8.39 (2H, s), 8.35 (1H, s), 7.86 (1H, s), 7.73 (1H, d, J = 1.4 Hz), 7.64-7.56 (4H, m), 7.53-           7.42 (3H, m), 2.88 (2H, q, J = 7.3 Hz), 1.26 (3H, t, J = 7.3 Hz).       1-248   8.38 (2H, s), 8.35 (1H, s), 7.86 (1H, s), 7.68 (1H, d, J = 1.8 Hz), 7.60 (1H, d, J = 8.2 Hz),           7.56-7.52 (3H, m), 7.49-7.45 (2H, m), 2.86 (2H, q, J = 7.3 Hz), 1.26 (3H, t, J = 7.3 Hz).       1-249   8.37 (2H, s), 8.24 (1H, s), 7.85 (1H, s), 7.44-7.39 (3H, m), 7.23-7.18 (1H, m), 7.11-7.08           (3H, m), 6.90 (1H, dd, J1 = 8.7 Hz, J2 = 2.7 Hz), 2.79 (2H, q, J = 7.3 Hz), 1.23 (3H, t, J = 7.6           Hz).       1-250   8.39 (1H, s), 8.38 (2H, s), 7.89 (1H, s), 7.75 (1H, d, J = 0.9 Hz), 7.70-7.65 (2H, m), 2.96           (2H, q, J = 7.3 Hz), 1.33 (3H, t, J = 7.6 Hz).       1-251   8.36 (2H, s), 8.27 (1H, s), 7.86 (1H, s), 7.61 (1H, d, J = 1.8 Hz), 7.49 (1H, dd, J1 = 8.2 Hz,           J2 = 1.8 Hz), 7.38 (1H, d, J = 8.2 Hz), 2.88 (2H, q, J = 7.3 Hz), 1.27 (3H, t, J = 7.6 Hz).       1-252   1H-NMR (DMSO-D6) δ: 12.82 (1H, br), 9.41 (1H, s), 8.62 (2H, s), 8.22 (1H, s), 8.13           (1H, s), 8.07 (1H, d, J = 8.2 Hz), 7.85 (1H, d, J = 8.2 Hz), 3.09 (2H, q, J = 7.3 Hz), 1.23 (3H, t,           J = 7.1 Hz).       1-254   8.40 (2H, s), 8.38 (1H, s), 8.32 (1H, d, J = 1.4 Hz), 8.13 (1H, dd, J = 8.2 Hz, 1.8 Hz), 7.88           (1H, s), 7.66 (1H, d, J = 8.2 Hz), 4.46 (3H, s), 2.99 (2H, q, J = 7.3 Hz), 1.32 (3H, t, J = 7.6           Hz).       1-255   8.36 (2H, s), 8.25 (1H, s), 7.84 (1H, s), 7.38 (1H, d, J = 8.2 Hz), 7.24 (1H, s), 7.02 (1H, dd,           J1 = 8.2 Hz, J2 = 1.8 Hz), 2.79 (2H, q, J = 7.3 Hz), 2.01-1.93 (1H, m), 1.21 (3H, t, J = 7.3 Hz),           1.11-1.05 (2H, m), 0.80-0.75 (2H, m).       1-256   8.26 (1H, s), 8.12 (2H, s), 7.58 (1H, s), 7.55-7.46 (3H, m), 7.37 (1H, td, J1 = 7.6 Hz, J2 = 1.7           Hz), 3.89 (2H, s), 2.82 (2H, q, J = 7.3 Hz), 1.23 (3H, t, J = 7.3 Hz).       1-257   8.40-8.39 (1H, m), 8.24 (1H, d, J = 1.4 Hz), 8.08 (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz), 7.88 (1H,           s), 7.68 (1H, d, J = 7.8 Hz), 2.97 (1H, q, J = 7.5 Hz), 1.31 (3H, t, J = 7.6 Hz).       1-258   8.38 (1H, s), 8.30 (1H, s), 7.86 (1H, s), 7.57 (1H, d, J = 1.4 Hz), 7.51 (1H, d, J = 8.2 Hz), 7.36           (1H, dd, J1 = 8.0 Hz, J2 = 1.6 Hz), 4.83 (2H, d, J = 5.5 Hz), 2.86 (2H, q, J = 7.3 Hz), 1.88 (1H,           t, J = 6.0 Hz), 1.25 (3H, t, J = 7.3 Hz).       1-259   8.25 (1H, s), 8.04 (2H, s), 7.55-7.46 (4H, m), 7.37 (1H, td, J1 = 7.4 Hz, J2 = 1.7 Hz), 2.82           (2H, q, J = 7.5 Hz), 1.84 (2H, dd, J1 = 8.0 Hz, J2 = 5.3 Hz), 1.56 (2H, dd, J1 = 8.0 Hz, J2 = 5.3           Hz), 1.23 (3H, t, J = 7.3 Hz).       1-261   8.36 (2H, s), 8.22 (1H, s), 7.84 (1H, s), 7.37-7.32 (3H, m), 7.18-7.04 (3H, m), 6.95 (1H, dd,           J1 = 8.7 Hz, J2 = 2.3 Hz), 6.77-6.67 (2H, m), 5.99 (1H, s), 2.75 (2H, q, J = 7.3 Hz), 1.22 (3H, t,           J = 7.3 Hz).       1-265   8.38-8.35 (3H, m), 8.20 (1H, s), 8.04-8.01 (1H, m), 7.88 (1H, s), 7.63 (1H, d, J = 8.2 Hz),           4.45 (2H, q, J = 7.2 Hz), 2.94 (2H, q, J = 7.3 Hz), 1.45 (3H, t, J = 7.1 Hz), 1.29 (3H, t, J = 7.3           Hz).       1-266   8.38 (2H, s), 8.37 (1H, s), 7.99 (1H, d, J = 1.8 Hz), 7.88 (1H, s), 7.65 (1H, dd, J1 = 8.2 Hz,           J2 = 1.8 Hz), 7.60 (1H, d, J = 8.2 Hz), 6.24 (1H, br), 3.08 (3H, d, J = 5.0 Hz), 2.93 (2H, q,           J = 7.3 Hz), 1.28 (3H, t, J = 7.3 Hz).       1-267   8.38 (2H, s), 8.31 (1H, s), 7.87 (1H, s), 7.56 (1H, d, J = 7.8 Hz), 7.50 (1H, d, J = 1.4 Hz), 7.34           (1H, dd, J1 = 8.2 Hz, J2 = 1.4 Hz), 3.88 (2H, s), 2.89 (2H, q, J = 7.3 Hz), 1.28 (3H, t, J = 7.3           Hz).       1-268   8.38 (2H, s), 8.31 (1H, s), 7.87 (1H, s), 7.55-7.51 (2H, m), 7.18 (1H, d, J = 8.2 Hz), 2.89           (2H, q, J = 7.3 Hz), 1.90-1.86 (2H, m), 1.54-1.52 (2H, m), 1.28 (3H, t, J = 7.6 Hz).       1-269   8.40 (2H, s), 8.19 (1H, s), 7.90 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 7.86 (1H, s), 7.66-7.59           (2H, m), 4.13 (2H, q, J = 7.0 Hz), 2.88 (2H, q, J = 7.3 Hz), 1.27 (3H, t, J = 7.3 Hz), 1.10 (3H, t,           J = 7.1 Hz).       1-270   8.38 (2H, s), 8.19 (1H, s), 7.86 (1H, s), 7.60-7.53 (2H, m), 7.49 (1H, dd, J1 = 6.9 Hz, J2 = 1.8           Hz), 5.89 (1H, br), 2.90 (2H, q, J = 7.3 Hz), 2.75 (3H, d, J = 4.6 Hz), 1.27 (3H, t, J = 7.3 Hz).       1-271   8.40 (2H, s), 8.03 (1H, s), 7.86 (1H, s), 7.18 (2H, s), 2.88 (4H, q, J = 7.3 Hz), 1.29 (6H, t,           J = 7.3 Hz).       1-273   8.40 (1H, s), 8.39 (2H, s), 8.12 (1H, d, J = 1.4 Hz), 7.92 (1H, dd, J1 = 8.0 Hz, J2 = 1.1 Hz),           7.88 (1H, s), 7.68 (1H, d, J = 8.3 Hz), 2.95 (2H, q, J = 7.3 Hz), 2.69 (3H, s), 1.29 (3H, t, J = 7.3           Hz).       1-274   8.41 (1H, s), 8.40 (2H, s), 7.95 (1H, d, J = 1.4 Hz), 7.89-7.85 (3H, m), 7.73 (1H, dd, J1 = 8.2           Hz, J2 = 1.4 Hz), 7.69-7.65 (2H, m), 7.55 (2H, t, J = 7.6 Hz), 2.93 (2H, q, J = 7.3 Hz), 1.29           (3H, t, J = 7.3 Hz).       1-275   8.74 (1H, dd, J1 = 6.9 Hz, J2 = 2.3 Hz), 8.37 (1H, d, J = 3.7 Hz), 7.63-7.59 (1H, m), 7.56-7.47           (3H, m), 7.39 (1H, td, J1 = 7.6 Hz, J2 = 1.5 Hz), 7.30 (1H, d, J = 9.6 Hz), 2.83 (2H, q, J = 7.3           Hz), 1.24 (3H, t, J = 7.3 Hz).       1-277   8.37 (2H, s), 8.28 (1H, s), 7.87 (1H, s), 7.82 (1H, d, J = 1.8 Hz), 7.71 (1H, dd, J1 = 8.2 Hz,           J2 = 1.8 Hz), 7.24 (1H, d, J = 8.7 Hz), 2.87 (2H, q, J = 7.3 Hz), 1.27 (3H, t, J = 7.3 Hz).       1-278   8.38 (2H, s), 8.29 (1H, s), 7.88 (1H, s), 7.56 (1H, d, J = 8.7 Hz), 7.32 (1H, d, J = 2.3 Hz),           7.24-7.21 (1H, m), 2.91 (2H, q, J = 7.3 Hz), 1.30 (3H, t, J = 7.3 Hz).       1-279   8.30 (1H, t, J = 1.4 Hz), 8.11 (2H, d, J = 8.2 Hz), 7.99 (1H, s), 7.69 (2H, d, J = 8.2 Hz), 7.06           (1H, d, J = 1.8 Hz), 3.23 (2H, q, J = 7.3 Hz), 1.48 (3H, t, J = 7.3 Hz).       1-280   8.61 (1H, s), 8.23 (1H, s), 7.66-7.58 (2H, m), 7.54 (1H, dd, J = 8.0 Hz, J2 = 1.1 Hz), 7.44           (1H, td, J1 = 7.4 Hz, J2 = 1.7 Hz), 2.90 (2H, q, J = 7.3 Hz), 1.12 (3H, t, J = 7.3 Hz).       1-281   8.42 (2H, s), 8.27 (1H, s), 8.25-8.23 (1H, m), 8.19-8.17 (2H, m), 7.92 (2H, br), 7.43-7.39           (1H, m), 2.91 (2H, q, J = 7.3 Hz), 1.11 (3H, t, J = 7.3 Hz).       1-282   8.54 (2H, s), 7.92 (1H, s), 7.86 (1H, br), 7.60-7.53 (2H, m), 7.50-7.48 (1H, m), 7.41 (1H,           td, J1 = 7.3 Hz, J2 = 1.8 Hz), 7.31-7.24 (4H, m), 7.16-7.12 (1H, m), 2.93 (2H, q, J = 7.3 Hz),           1.28 (3H, t, J = 7.6 Hz).       1-283   8.54 (2H, s), 7.94 (1H, s), 7.79 (1H, br), 7.61-7.54 (2H, m), 7.51-7.42 (2H, m), 7.27-7.20           (4H, m), 2.93 (2H, q, J = 7.3 Hz), 1.28 (3H, t, J = 7.6 Hz).       1-284   8.46 (2H, s), 7.91 (1H, s), 7.59-7.51 (2H, m), 7.46-7.39 (2H, m), 6.13 (1H, br), 2.90 (2H, q,           J = 7.3 Hz), 2.81 (3H, d, J = 5.0 Hz), 1.26 (3H, t, J = 7.3 Hz).       1-285   8.32 (2H, s), 7.90 (1H, s)7.53 (2H, dd, J1 = 4.8 Hz, J2 = 1.1 Hz), 7.49 (1H, dd, J1 = 7.8 Hz,           J2 = 0.9 Hz), 7.41-7.36 (1H, m), 3.00 (3H, s), 2.91 (2H, q, J = 7.5 Hz), 1.25 (3H, t, J = 7.3 Hz).       1-286   8.34 (1H, br), 8.28 (2H, s), 7.91 (1H, s), 7.62-7.56 (2H, m), 7.54-7.45 (2H, m), 2.82 (2H, q,           J = 7.3 Hz), 1.27 (3H, t, J = 7.3 Hz).       1-287   8.39 (2H, s), 8.03 (1H, br), 7.85 (1H, s), 7.69 (2H, d, J = 7.3 Hz), 7.60-7.41 (7H, m), 2.80           (2H, q, J = 7.3 Hz), 1.25 (3H, t, J = 7.3 Hz).       1-288   8.37 (2H, s), 8.03 (1H, s), 7.86 (1H, s), 7.66 (1H, br), 7.59-7.52 (5H, m), 7.46-7.39 (2H,           m), 2.82 (2H, q, J = 7.3 Hz), 1.27 (3H, t, J = 7.3 Hz).       1-289   8.37 (2H, s), 8.01 (1H, br), 7.85 (1H, s), 7.64 (2H, d, J = 8.2 Hz), 7.58-7.51 (3H, m), 7.46-           7.42 (3H, m), 2.79 (2H, q, J = 7.5 Hz), 1.29 (3H, t, J = 7.3 Hz).       1-290   8.22 (2H, s), 7.92 (1H, s), 7.55-7.53 (2H, m), 7.34-7.30 (1H, m), 7.27-7.25 (1H, m), 3.00           (2H, q, J = 7.3 Hz), 2.31 (6H, s), 1.30 (3H, t, J = 7.3 Hz).       1-291   9.29 (1H, s), 8.80 (1H, s), 8.52 (1H, s), 8.16 (1H, s), 7.69-7.59 (3H, m), 7.45 (1H, td,           J1 = 7.4 Hz, J2 = 1.5 Hz), 2.96 (2H, q, J = 7.2 Hz), 1.17 (3H, t, J = 7.3 Hz).       1-292   8.45 (2H, s), 8.03 (1H, br), 7.88 (1H, s), 7.58-7.49 (4H, m), 7.45-7.33 (4H, m), 2.79 (2H, q,           J = 7.3 Hz), 1.23 (3H, t, J = 7.3 Hz).       1-295   8.25 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.17 (1H, s), 7.93-7.91 (2H, m), 7.76 (1H, td, J1 = 7.6           Hz, J2 = 1.4 Hz), 7.69 (1H, td, J1 = 7.6 Hz, J2 = 1.7 Hz), 7.55 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz),           7.51-7.47 (2H, m), 7.43-7.39 (1H, m), 3.36-3.27 (1H, m), 2.94-2.85 (1H, m), 1.35 (3H, t,           J = 7.3 Hz).       1-300   8.25 (1H, dd, J1 = 8.0 Hz, J2 = 1.6 Hz), 8.18 (1H, s), 7.92 (1H, t, J = 1.8 Hz), 7.81-7.75 (2H,           m), 7.69 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz), 7.54 (1H, dd, J1 = 8.0 Hz, J2 = 1.1 Hz), 7.42 (1H, t,           J = 7.6 Hz), 7.38 (1H, dt, J1 = 7.9 Hz, J2 = 1.7 Hz), 3.34-3.25 (1H, m), 2.94-2.85 (1H, m), 1.35           (3H, t, J = 7.6 Hz).       1-301   8.25 (1H, dd, J1 = 8.0 Hz, J2 = 1.6 Hz), 8.16 (1H, s), 7.87-7.83 (1H, m), 7.77 (1H, td, J1 = 7.7           Hz, J2 = 1.2 Hz), 7.69 (1H, td, J1 = 7.7 Hz, J2 = 1.5 Hz), 7.54 (1H, dd, J1 = 7.8 Hz, J2 = 0.9 Hz),           7.48-7.45 (1H, m), 3.36-3.27 (1H, m), 2.95-2.86 (1H, m), 1.36 (1H, t, J = 7.3 Hz).       1-302   8.25 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.17 (1H, s), 8.08 (1H, t, J = 1.6 Hz), 7.84 (1H, dt,           J1 = 7.8 Hz, J2 = 1.4 Hz), 7.77 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz), 7.69 (1H, td, J1 = 7.7 Hz,           J2 = 1.5 Hz), 7.55-7.52 (2H, m), 7.36 (1H, t, J = 7.8 Hz), 3.34-3.25 (1H, m), 2.94-2.85 (1H,           m), 1.35 (3H, t, J = 7.6 Hz).       1-303   8.26 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.20 (1H, s), 7.84 (1H, d, J = 7.8 Hz), 7.80-7.76 (2H,           m), 7.69 (1H, td, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.56-7.50 (2H, m), 3.36-3.27 (1H, m), 2.96-2.87           (1H, m), 1.36 (3H, t, J = 7.3 Hz).       1-304   8.25 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.17 (1H, s), 8.04 (1H, d, J = 7.8 Hz), 7.82 (1H, d,           J = 8.2 Hz), 7.78 (1H, td, J1 = 7.7 Hz, J2 = 1.2 Hz), 7.70 (1H, td, J1 = 7.7 Hz, J2 = 1.7 Hz), 7.58-           7.54 (2H, m), 3.27-3.18 (1H, m), 2.87-2.78 (1H, m), 1.33 (3H, t, J = 7.3 Hz).       1-305   8.27-8.25 (2H, m), 8.18 (1H, s), 8.11 (1H, d, J = 7.3 Hz), 7.78 (1H, td, J1 = 7.7 Hz, J2 = 1.1           Hz), 7.70 (1H, td, J1 = 7.7 Hz, J2 = 1.5 Hz), 7.66-7.60 (2H, m), 7.56 (1H, dd, J1 = 7.8 Hz,           J2 = 0.9 Hz), 3.37-3.28 (1H, m), 2.96-2.87 (1H, m), 1.37 (3H, t, J = 7.3 Hz).       1-306   8.22 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.10 (1H, s), 7.99 (1H, d, J = 7.3 Hz), 7.84 (1H, td,           J1 = 7.7 Hz, J2 = 1.2 Hz), 7.74 (1H, td, J1 = 7.7 Hz, J2 = 1.5Z Hz), 7.68-7.61 (2H, m), 7.42 (1H,           dd, J1 = 7.8 Hz, J2 = 0.9 Hz), 3.21-3.12 (1H, m), 2.87 (1H, m), 2.47 (3H, s), 1.27 (3H, t,           J = 7.3 Hz).       1-308   8.36 (1H, s), 8.27-8.22 (2H, m), 7.87 (1H, td, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.75 (1H, td, J1 = 7.7           Hz, J2 = 1.7 Hz), 7.72-7.63 (2H, m), 7.51 (1H, dd, J1 = 8.0 Hz, J2 = 1.1 Hz), 3.20-3.11 (1H,           m), 2.88-2.79 (1H, m), 1.29 (3H, t, J = 7.3 Hz).       1-310   8.36 (1H, s), 8.27 (1H, d, J = 7.8 Hz), 8.22 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.87 (1H, td,           J1 = 7.8 Hz, J2 = 1.4 Hz), 7.77-7.71 (2H, m), 7.65 (1H, t, H = 7.8 Hz), 7.47 (1H, dd, J1 = 7.8           Hz, J2 = 1.4 Hz), 3.13-3.04 (1H, m), 2.83-2.75 (1H, m), 1.25 (3H, t, J = 7.3 Hz).       1-317   8.43 (1H, d, J = 8.2 Hz), 8.33 (1H, s), 8.19 (1H, s), 8.12 (1H, d, J = 7.8 Hz), 8.02 (1H, dd,           J1 = 8.5 Hz, J2 = 1.1 Hz), 7.83 (1H, s), 7.70-7.62 (2H, m), 3.44-3.35 (1H, m)3.00-2.91 (1H,           m), 1.40 (3H, t, J = 7.3 Hz).       1-319   8.26 (1H, dd, J1 = 7.8 Hz, J2 = 1.8 Hz), 8.25 (1H, s), 8.04 (2H, d, J = 8.2 Hz), 7.80-7.68 (4H,           m), 7.56 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 3.36-3.27 (1H, m), 2.96-2.87 (1H, m), 1.36 (3H,           t, J = 7.6 Hz).       1-332   8.24 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.14 (1H, s), 7.84 (2H, dt, J1 = 8.9 Hz, J2 = 2.2 Hz),           7.75 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz), 7.68 (1H, td, J1 = 7.6 Hz, J2 = 1.7 Hz), 7.55 (1H, dd,           J1 = 7.8 Hz, J2 = 0.9 Hz), 7.51 (2H, dt, J1 = 8.7 Hz, J2 = 2.1 Hz), 3.34-3.25 (1H, m), 2.93-2.84           (1H, m), 1.37 (9H, s), 1.34 (3H, t, J = 7.3 Hz).       1-333   8.26 (1H, dd, J1 = 8.0 Hz, J2 = 1.6 Hz), 8.21 (1H, s), 7.99 (2H, dt, J1 = 8.7 Hz, J2 = 1.8 Hz),           7.79-7.65 (6H, m), 7.57 (1H, dd, J1 = 8.0 Hz, J2 = 1.1 Hz), 7.50-7.46 (2H, m), 7.41-7.36 (1H,           m), 3.36-3.28 (1H, m), 2.95-2.86 (1H, m), 1.36 (3H, t, J = 7.3 Hz).       1-334   8.25 (1H, d, J = 7.8 Hz), 8.12 (1H, s), 7.87 (2H, d, J = 7.8 Hz), 7.76 (1H, t, J = 7.6 Hz), 7.68           (1H, t, J = 7.8 Hz), 7.55 (1H, d, J = 7.8 Hz), 7.38 (2H, t, J = 7.6 Hz), 7.18-7.07 (5H, m), 3.36-           3.27 (1H, m), 2.95-2.86 (1H, m), 1.36 (3H, t, J = 7.1 Hz).       1-335   8.26 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.26 (1H, s), 8.03 (1H, dt, J1 = 8.7 Hz, J2 = 1.8 Hz),           7.81-7.77 (3H, m), 7.70 (1H, td, J1 = 7.7 Hz, J2 = 1.5 Hz), 7.54 (1H, dd, J1 = 7.8 Hz, J2 = 0.9           Hz), 3.35-3.26 (1H, m), 2.96-2.87 (1H, m), 1.36 (3H, t, J = 7.6 Hz).       1-336   8.69 (1H, s), 8.50 (1H, d, J = 7.8 Hz), 8.26 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.81-7.77 (2H,           m), 7.73-7.68 (2H, m), 7.59 (1H, dd, J1 = 7.8 Hz, J2 = 0.9 Hz), 3.33-3.24 (1H, m), 2.94-2.85           (1H, m), 1.36 (3H, t, J = 7.6 Hz).       1-354   8.38 (2H, s), 8.34 (1H, s), 8.27 (1H, dd, J1 = 8.0 Hz, J2 = 1.6 Hz), 7.91 (1H, s), 7.80 (1H, td,           J1 = 7.7 Hz, J2 = 1.2 Hz), 7.71 (1H, td, J1 = 7.7 Hz, J2 = 1.5 Hz), 7.56 (1H, dd, J1 = 7.8 Hz,           J2 = 0.9 Hz), 3.36-3.28 (1H, m), 2.97-2.88 (1H, m), 1.37 (3H, t, J = 7.3 Hz).       1-360   8.59 (2H, s), 8.23 (1H, dd, J1 = 8.0 Hz, J2 = 1.6 Hz), 7.96 (1H, s), 7.89 (1H, td, J1 = 7.7 Hz,           J2 = 1.2 Hz), 7.77 (1H, td, J1 = 7.7 Hz, J2 = 1.5 Hz), 7.47 (1H, dd, J1 = 8.0 Hz, J2 = 1.1 Hz),           3.14-3.05 (1H, m), 2.85-2.76 (1H, m), 1.26 (3H, t, J = 7.3 Hz).       1-361   8.25 (2H, s), 8.22 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.87-7.83 (2H, m), 7.76 (1H, td, J1 = 7.7           Hz, J2 = 1.5 Hz), 7.52 (1H, td, J1 = 7.8 Hz, J2 = 0.9 Hz), 4.20 (2H, s), 3.25-3.16 (1H, m), 2.95-           2.86 (1H, m), 1.29 (3H, t, J = 7.3 Hz).       1-362   8.50 (2H, s), 8.16 (1H, dd, J1 = 8.2 Hz, J2 = 1.4 Hz), 7.99 (1H, s), 7.85 (1H, td, J1 = 7.7 Hz,           J2 = 1.2 Hz), 7.71 (1H, td, J1 = 7.7 Hz, J2 = 1.7 Hz), 7.45 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz),           4.22 (2H, q, J = 7.2 Hz), 3.05-2.96 (1H, m), 2.78-2.69 (1H, m), 1.24 (3H, t, J = 7.6 Hz), 1.06           (3H, t, J = 7.1 Hz).       1-363   8.62 (2H, s), 8.30 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.05 (1H, s), 7.93 (1H, td, J1 = 7.7 Hz,           J2 = 1.1 Hz), 7.82 (1H, td, J1 = 7.7 Hz, J2 = 1.7 Hz), 7.67 (1H, dd, J1 = 8.0 Hz, J2 = 1.1 Hz),           3.32-3.23 (1H, m), 3.00-2.91 (1H, m), 1.38 (3H, t, J = 7.3 Hz).       1-364   8.36 (2H, s), 8.28 (1H, s), 7.87 (1H, s), 7.68 (1H, d, J = 8.2 Hz), 7.61 (1H, t, J = 8.0 Hz), 7.41           (1H, d, J = 7.8 Hz), 3.71-3.62 (1H, m), 3.29-3.20 (1H, m), 1.41 (3H, t, J = 7.6 Hz).       1-365   8.37 (2H, s), 8.32 (1H, s), 8.23 (1H, d, J = 2.3 Hz), 7.91 (1H, s), 7.67 (1H, dd, J1 = 8.2 Hz,           J2 = 2.3 Hz), 7.51 (1H, d, J = 8.7 Hz), 3.39-3.30 (1H, m), 2.98-2.89 (1H, m), 1.39 (3H, t,           J = 7.6 Hz).       1-366   8.36 (2H, s), 8.34 (1H, s), 8.21 (1H, d, J = 8.7 Hz), 7.89 (1H, s), 7.80 (1H, dd, J1 = 8.5 Hz,           J2 = 2.1 Hz), 7.60 (1H, d, J = 2.3 Hz), 3.21 (2H, q, J = 7.5 Hz), 1.27 (3H, t, J = 7.6 Hz).       1-367   8.39 (2H, s), 8.29 (1H, s), 8.10 (1H, dd, J1 = 5.7 Hz, J2 = 3.4 Hz), 7.91 (1H, s), 7.79 (1H, d,           J = 2.3 Hz), 3.27-3.18 (1H, m), 2.94-2.85 (1H, m), 1.32 (3H, t, J = 7.6 Hz).       1-369   8.58 (1H, d, J = 1.8 Hz), 8.41 (1H, s), 8.39 (1H, s), 7.97 (1H, dd, J1 = 8.2 Hz, J2 = 1.4 Hz),           7.93 (1H, s), 7.72 (1H, d, J = 8.2 Hz), 3.45-3.36 (1H, m), 3.01-2.92 (1H, m), 1.42 (3H, t,           J = 7.6 Hz).       1-370   8.45-8.43 (2H, m), 8.39 (1H, s), 8.04 (1H, d, J = 8.2 Hz), 7.93 (1H, s), 7.83 (1H, s), 3.44-           3.35 (1H, m), 3.01-2.92 (1H, m), 1.41 (3H, t, J = 7.3 Hz).       1-475   8.29 (1H, s), 8.26-8.21 (2H, m), 8.09 (1H, s), 7.78-7.73 (2H, m), 7.68 (1H, td, J1 = 7.6 Hz,           J2 = 1.4 Hz), 7.53 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 3.34-3.25 (1H, m), 2.94-2.84 (1H, m),           1.34 (3H, t, J1 = 7.6 Hz).       1-488   8.70 (1H, s), 8.45 (1H, s), 8.34 (1H, s), 8.32 (1H, s), 8.27 (1H, dd, J1 = 8.0 Hz, J2 = 1.6 Hz),           7.79 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz), 7.71 (1H, td, J1 = 7.7 Hz, J2 = 1.5 Hz), 7.56 (1H, dd,           J1 = 7.8 Hz, J2 = 1.4 Hz), 4.01 (3H, s), 3.37-3.28 (1H, m), 2.97-2.88 (1H, m), 1.37 (3H, t,           J = 7.3 Hz).       1-505   8.62 (1H, s), 8.36 (1H, s), 8.35 (1H, s), 8.27 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.17 (1H, s),           7.98 (1H, br), 7.80 (1H, t, J = 7.6 Hz), 7.74-7.68 (3H, m), 7.57 (1H, d, J = 7.8 Hz), 7.43 (1H,           t, J = 8.0 Hz), 3.38-3.29 (1H, m), 2.98-2.89 (1H, m), 1.38 (3H, t, J = 7.3 Hz).       1-506   8.60 (1H, s), 8.34 (1H, s), 8.32 (1H, s), 8.24 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.16 (1H, br),           7.77 (1H, td, J1 = 7.6 Hz, J2 = 1.2 Hz), 7.72 (1H, dd, J1 = 7.8 Hz, J2 = 1.8 Hz), 7.70-7.65 (2H,           m), 7.55 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.40-7.36 (2H, m), 3.37-3.28 (1H, m), 2.98-           2.89 (1H, m), 1.37 (3H, t, J = 7.3 Hz).       1-507   8.38 (2H, s), 8.35 (1H, s), 8.27 (1H, dd, J1 = 8.9 Hz, J2 = 5.7 Hz), 7.92 (1H, s), 7.50 (1H,           ddd, J1 = 9.3 Hz, J2 = 7.0 Hz, J3 = 1.9 Hz), 7.33 (1H, dd, J1 = 8.2 Hz, J2 = 2.3 Hz), 3.37-3.28           (1H, m), 2.98-2.89 (1H, m), 1.38 (3H, t, J = 7.3 Hz).       1-508   8.38 (2H, s), 8.33 (1H, s), 8.12 (1H, d, J = 8.2 Hz), 7.90 (1H, s), 7.59 (1H, dd, J1 = 7.8 Hz,           J2 = 0.9 Hz), 7.37 (1H, d, J = 0.9 Hz), 3.32-3.23 (1H, m), 2.95-2.86 (1H, m), 2.54 (3H, s),           1.35 (3H, t, J = 7.6 Hz).       1-509   8.38 (2H, s), 8.33 (1H, s), 8.14 (1H, d, J = 9.2 Hz), 7.90 (1H, s), 7.28 (2H, dd, J1 = 8.9 Hz,           J2 = 2.5 Hz), 7.05 (1H, d, J = 2.3 Hz), 3.95 (3H, s), 3.27-3.20 (1H, m), 2.95-2.86 (1H, m),           1.34 (3H, t, J = 7.3 Hz).       1-510   8.61 (1H, s), 8.38 (2H, s), 8.19 (1H, s), 7.92 (1H, d, J = 1.8 Hz), 7.89 (1H, s), 3.62-3.53 (1H,           m), 3.39-3.30 (1H, m), 1.31 (3H, t, J = 7.3 Hz).       1-511   8.25 (1H, s), 8.24 (1H, d, J = 9.6 Hz), 8.04 (2H, d, J = 7.3 Hz), 7.78-7.69 (4H, m), 3.34-3.25           (1H, m), 2.94-2.86 (1H, m), 1.34 (3H, t, J = 7.3 Hz).       1-512   8.38 (2H, s), 8.27 (1H, dd, J1 = 8.2 Hz, J2 = 1.4 Hz), 7.91 (1H, s), 7.86 (1H, td, J1 = 7.7 Hz,           J2 = 1.1 Hz), 7.76 (1H, td, J1 = 7.7 Hz, J2 = 1.5 Hz), 7.55 (1H, d, J = 7.8 Hz), 3.31-3.22 (1H,           m), 2.98-2.89 (1H, m), 1.36 (3H, t, J = 7.6 Hz).       1-513   8.32 (1H, t, J = 1.8 Hz), 8.26 (1H, s), 8.26 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.06 (1H, d,           J = 7.8 Hz), 7.79-7.77 (2H, m), 7.70 (1H, td, J1 = 7.7 Hz, J2 = 1.7 Hz), 7.60 (1H, t, J = 8.0 Hz),           7.56 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 3.32 (1H, td, J1 = 7.6 Hz, J2 = 5.8 Hz), 2.92 (1H, td,           J1 = 7.3 Hz, J2 = 6.0 Hz), 1.36 (3H, t, J = 7.3 Hz).       1-514   8.58 (1H, s), 8.33 (2H, s), 8.18 (1H, dd, J1 = 8.2 Hz, J2 = 1.4 Hz), 8.13 (1H, s), 7.70 (1H, td,           J1 = 7.6 Hz, J2 = 1.2 Hz), 7.63 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz), 7.50 (1H, dd, J1 = 7.8 Hz,           J2 = 0.9 Hz), 3.26-3.22 (1H, m), 2.90-2.80 (1H, m), 2.65 (3H, s), 1.29 (3H, t, J = 7.3 Hz).       1-515   8.35 (2H, s), 8.33 (1H, s), 8.26 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.89 (1H, s), 7.79 (1H, td,           J1 = 7.7 Hz, J2 = 1.2 Hz), 7.71 (1H, td, J1 = 7.7 Hz, J2 = 1.5 Hz), 7.56 (1H, dd, J1 = 7.8 Hz,           J2 = 1.4 Hz), 6.60 (1H, br), 3.36-3.28 (1H, m), 2.97 (3H, d, J = 5.0 Hz), 2.96-2.87 (1H, m),           1.37 (3H, t, J = 7.3 Hz).       1-516   8.24-8.21 (1H, m), 8.20 (1H, s), 7.80-7.65 (4H, m), 7.56-7.51 (1H, m), 7.37 (1H, t, J = 1.8           Hz), 3.33-3.23 (1H, m), 2.94-2.83 (1H, m), 1.34 (3H, t, J = 7.3 Hz).       1-517   8.42 (2H, s), 8.38 (1H, s), 8.27 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.93 (1H, s), 7.81 (1H, td,           J1 = 7.7 Hz, J2 = 1.1 Hz), 7.72 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz), 7.57 (1H, dd, J1 = 8.0 Hz,           J2 = 1.1 Hz), 3.37-3.28 (1H, m), 2.98-2.89 (1H, m), 1.38 (3H, t, J = 7.6 Hz).       1-518   8.46 (2H, s), 8.36 (1H, s), 8.25 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.05 (1H, s), 7.86-7.83           (2H, m), 7.78 (1H, td, J1 = 7.7 Hz, J2 = 1.2 Hz), 7.72-7.65 (2H, m), 7.56-7.54 (3H, m), 3.35-           3.30 (1H, m), 2.95-2.90 (1H, m), 1.36 (3H, t, J = 7.3 Hz).       1-519   8.41 (1H, s), 8.35 (3H, s), 8.25 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.96 (1H, s), 7.77 (1H, td,           J1 = 7.6 Hz, J2 = 1.2 Hz), 7.70 (1H, td, J1 = 7.7 Hz, J2 = 1.5 Hz), 7.60 (2H, dd, J1 = 8.9 Hz,           J2 = 1.1 Hz), 7.55 (1H, dd, J1 = 8.0 Hz, J2 = 1.1 Hz), 7.37 (2H, t, J = 8.0 Hz), 7.21 (1H, tt,           J1 = 7.6 Hz, J2 = 1.3 Hz), 3.32 (1H, dq, J1 = 17.9 Hz, J2 = 5.0 Hz), 2.92 (1H, dq, J1 = 17.7 Hz,           J2 = 5.0 Hz), 1.36 (3H, t, J = 7.3 Hz).       1-520   8.42 (1H, s), 8.25-8.23 (3H, m), 7.76-7.75 (2H, m), 7.69 (1H, t, J = 7.8 Hz), 7.58 (1H, d,           J = 7.8 Hz), 3.35-3.30 (1H, m), 2.94-2.90 (1H, m), 2.01 (3H, t, J = 18.3 Hz), 1.36 (3H, t,           J = 7.6 Hz).       1-522   8.34 (1H, s), 8.30 (1H, s), 8.25 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.11 (1H, s), 7.85 (1H, s),           7.79-7.74 (1H, m), 7.71-7.65 (3H, m), 7.56 (1H, dd, J1 = 7.8, J2 = 1.4 Hz), 7.52-7.40 (3H,           m), 3.37-3.27 (1H, m), 2.96-2.86 (1H, m), 1.36 (3H, t, J = 7.3 Hz).       1-523   8.27-8.23 (2H, m), 7.88 (1H, s), 7.84 (1H, s), 7.77 (1H, t, J = 7.6 Hz), 7.69 (1H, t, J = 7.6 Hz),           7.55 (1H, d, J = 7.8 Hz), 7.35 (1H, s), 3.37-3.28 (1H, m), 2.96-2.87 (1H, m), 2.07-2.01 (1H,           m), 1.36 (3H, t, J = 7.6 Hz), 1.12-1.07 (2H, m), 0.86-0.82 (2H, m).       1-524   8.43 (1H, s), 8.41 (1H, d, J = 1.8 Hz), 8.36 (2H, s), 7.88-7.82 (2H, m), 7.66-7.59 (3H, m),           7.48-7.38 (3H, m), 3.41-3.31 (1H, m), 3.00-2.91 (1H, m), 1.39 (3H, t, J = 7.3 Hz).       1-525   8.41 (1H, d, J = 1.8 Hz), 8.37 (3H, s), 7.90 (1H, s), 7.85 (1H, dd, J1 = 8.2 Hz, 1.8 Hz), 7.65-           7.61 (3H, m), 7.48 (2H, d, J = 8.2 Hz), 3.37 (1H, m), 2.96 (1H, m), 1.40 (3H, t, J = 7.3 Hz).       1-526   8.35 (2H, s), 8.31 (1H, s), 7.87 (1H, s), 7.78 (1H, d, J = 2.7 Hz), 7.48-7.38 (3H, m), 7.25-           7.18 (2H, m), 7.09 (2H, d, J = 7.8 Hz), 3.29-3.22 (1H, m), 2.90-2.82 (1H, m), 1.31 (3H, t,           J = 7.6 Hz).       1-527   8.61 (1H, s), 8.43 (1H, s), 8.38 (2H, s), 7.99 (1H, d, J = 8.2 Hz), 7.94 (1H, s), 7.72 (1H, d,           J = 8.2 Hz).3.48-3.39 (1H, m), 3.03-2.94 (1H, m), 1.43 (3H, t, J = 7.6 Hz).       1-528   8.37-8.35 (3H, m), 8.33 (1H, s), 7.90 (1H, s), 7.81 (1H, dd, J1 = 8.5 Hz, J2 = 2.1 Hz), 7.43           (1H, d, J = 8.7 Hz), 3.39-3.29 (1H, m), 2.97-2.88 (1H, m), 1.38 (3H, t, J = 7.6 Hz).       1-529   1H-NMR (DMSO-D6) 8: 12.55 (1H, br), 9.76 (1H, s), 8.76 (1H, d, J = 1.8 Hz), 8.62 (2H,           s), 8.49 (1H, dd, J1 = 8.2 Hz, J2 = 1.4 Hz), 8.17 (1H, s), 8.13 (1H, d, J = 8.7 Hz), 3.30-3.26           (1H, m), 2.85-2.81 (1H, m), 1.20 (3H, t, J = 7.3 Hz).       1-531   9.01 (1H, d, J = 1.4 Hz), 8.50 (1H, dd, J1 = 8.2 Hz, J2 = 0.9 Hz), 8.42 (1H, s), 8.40 (2H, s),           7.92 (1H, s), 7.70 (1H, d, J = 8.2 Hz), 4.47 (3H, s), 3.41 (1H, td, J1 = 14.1 Hz, J2 = 6.7 Hz),           3.02 (1H, td, J1 = 13.7 Hz, J2 = 7.2 Hz), 1.43 (3H, t, J = 7.3 Hz).       1-532   8.35 (2H, s), 8.32 (1H, s), 7.86 (2H, s), 7.41-7.28 (2H, m), 3.30-3.20 (1H, m), 2.90-2.80           (1H, m), 2.09-2.01 (1H, m), 1.32 (3H, t, J = 7.6 Hz), 1.16-1.10 (1H, m), 0.88-0.79 (1H, m).       1-536   8.31 (1H, s), 8.24 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.06 (2H, s), 7.79-7.74 (1H, m), 7.71-           7.66 (1H, m), 7.56-7.53 (2H, m), 3.36-3.26 (1H, m), 2.96-2.86 (1H, m), 1.87-1.84 (2H, m),           1.58-1.54 (2H, m), 1.35 (3H, t, J = 7.3 Hz).       1-537   8.97 (1H, d, J = 1.8 Hz), 8.42 (1H, s), 8.40-8.38 (3H, m), 7.92 (1H, s), 7.69 (1H, d, J = 8.2           Hz), 3.45-3.36 (1H, m), 3.06-2.97 (1H, m), 1.43 (3H, t, J = 7.3 Hz).       1-538   8.35 (2H, s), 8.21 (1H, s), 7.87 (1H, s), 7.71 (1H, d, J = 2.3 Hz), 7.39-7.32 (3H, m), 7.26-           7.18 (3H, m), 7.10 (1H, t, J = 7.6 Hz), 6.53 (1H, s), 3.29-3.21 (1H, m), 2.92-2.84 (1H, m),           1.34 (3H, t, J = 7.6 Hz).       1-542   8.91 (1H, d, J = 1.4 Hz), 8.41 (1H, s), 8.39-8.36 (3H, m), 7.92 (1H, s), 7.66 (1H, d, J = 8.2           Hz), 4.48 (2H, q, J = 7.0 Hz), 3.45-3.36 (1H, m), 3.03-2.94 (1H, m), 1.48-1.42 (6H, s).       1-543   1H-NMR (DMSO-D6) 8: 9.70 (1H, s), 8.86 (1H, d, J = 4.6 Hz), 8.61 (2H, s), 8.55 (1H, d,           J = 1.8 Hz), 8.24 (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz), 8.17 (1H, s), 7.99 (1H, d, J = 8.2 Hz), 3.27-           3.18 (1H, m), 2.85 (3H, d, J = 4.6 Hz), 2.83-2.76 (1H, m), 1.18 (3H, t, J = 7.3 Hz).       1-545   8.38 (2H, s), 8.34 (1H, s), 7.91-7.86 (3H, m), 7.58 (1H, d, J = 7.8 Hz), 3.39-3.30 (1H, m),           2.93-2.84 (1H, m), 1.95-1.91 (2H, m), 1.66-1.62 (2H, m), 1.37 (3H, t, J = 7.6 Hz).       1-547   8.36 (2H, s), 8.34 (1H, s), 8.25 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.89-7.83 (3H, m), 5.83           (1H, s), 3.09 (1H, td, J1 = 14.2 Hz, J2 = 6.9 Hz), 2.80 (3H, d, J = 5.0 Hz), 2.79-2.72 (1H, m),           1.26 (3H, t, J = 7.6 Hz).       1-550   8.81 (1H, s), 8.43 (1H, s), 8.39 (2H, s), 8.30 (1H, d, J = 8.2 Hz), 7.93 (1H, s), 7.70 (1H, d,           J = 8.2 Hz), 3.47-3.39 (1H, m), 3.03-2.94 (1H, m), 2.77 (3H, s), 1.44 (3H, t, J = 7.6 Hz).       1-551   8.64 (1H, s), 8.45 (1H, s), 8.40 (2H, s), 8.17 (1H, d, J = 8.2 Hz), 7.93 (1H, s), 7.85 (2H, d,           J = 7.8 Hz), 7.73 (1H, d, J = 8.2 Hz), 7.68 (1H, t, J = 8.0 Hz), 7.56 (2H, t, J = 7.3 Hz), 3.46-3.38           (1H, m), 3.05-2.96 (1H, m), 1.42 (3H, t, J = 7.6 Hz).       1-552   8.71 (1H, dd, J1 = 6.9 Hz, J2 = 2.3 Hz), 8.39 (1H, d, J = 3.2 Hz), 8.26 (1H, dd, J1 = 7.8 Hz,           J2 = 1.4 Hz), 7.78 (1H, td, J1 = 7.7 Hz, J2 = 1.2 Hz), 7.70 (1H, dd, J1 = 7.6 Hz, J2 = 1.4 Hz),           7.68-7.64 (1H, m), 7, 57 (1H, dd, J1 = 8.0 Hz, J2 = 1.1 Hz), 7.33 (1H, t, J = 9.4 Hz), 3.36-3.28           (1H, m), 2.96-2.87 (1H, m), 1.37 (3H, t, J = 7.3 Hz).       1-554   8.54 (1H, d, J = 1.8 Hz), 8.37 (2H, s), 8.32 (1H, s), 8.03 (1H, dd, J1 = 8.5 Hz, J2 = 2.1 Hz),           7.91 (1H, s), 7.28 (1H, d, J = 8.2 Hz), 3.40-3.31 (1H, m), 2.98-2.89 (1H, m), 1.40 (3H, t,           J = 7.3 Hz).       1-555   8.38 (2H, s), 8.34 (1H, s), 8.12 (1H, d, J = 2.3 Hz), 7.92 (1H, s), 7.63 (1H, d, J = 8.7 Hz), 7.54           (1H, dd, J1 = 8.7 Hz, J2 = 2.7 Hz), 3.40-3.31 (1H, m), 2.98-2.90 (1H, m), 1.38 (3H, t, J = 7.3           Hz).       1-556   8.60 (1H, t, J = 1.4 Hz), 8.12 (1H, s), 8.08 (2H, d, J = 7.8 Hz), 7.88 (1H, d, J = 1.8 Hz), 7.72           (2H, d, J = 8.2 Hz), 3.62-3.53 (1H, m), 3.40-3.41 (1H, m), 1.30 (3H, t, J = 7.6 Hz).       1-559   9.83 (1H, s), 8.55 (2H, s), 7.90 (1H, s), 7.81 (1H, dd, J1 = 5.7 Hz, J2 = 3.4 Hz), 7.72 (2H, dd,           J1 = 5.7 Hz, J2 = 3.4 Hz), 7.56 (1H, dd, J1 = 6.0 Hz, J2 = 3.2 Hz), 7.45-7.42 (2H, m), 7.30-7.26           (2H, m), 7.14-7.10 (1H, m), 3.42-3.26 (2H, m), 1.30 (3H, t, J = 7.6 Hz).       1-560   10.31 (1H, s), 8.47 (2H, s), 7.91 (1H, s), 7.84-7.82 (1H, m), 7.72-7.68 (2H, m), 7.60-7.58           (1H, m), 7.41-7.38 (2H, m), 7.23-7.20 (2H, m), 3.28-3.18 (1H, m), 3.15-3.07 (1H, m), 1.17           (3H, t, J = 7.6 Hz).       1-561   8.46 (2H, s), 7.96 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 7.91 (1H, s), 7.79 (1H, td, J1 = 7.7 Hz,           J2 = 1.5 Hz), 7.73 (1H, td, J1 = 7.7 Hz, J2 = 1.5 Hz), 7.54 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz),           7.04 (1H, br), 3.30 (2H, m), 2.79 (3H, d, J = 5.0 Hz), 1.31 (3H, t, J = 7.6 Hz).       1-562   8.35 (2H, s), 8.22 (1H, d, J = 8.7 Hz), 7.92 (1H, s), 7.82 (1H, td, J1 = 7.7 Hz, J2 = 1.1 Hz),           7.69 (1H, td, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.61 (1H, br), 3.41 (1H, dd, J1 = 14.2 Hz, J2 = 7.8 Hz),           3.08 (1H, dd, J1 = 13.5 Hz, J2 = 7.6 Hz), 3.02 (3H, s), 2.67 (3H, s), 1.41 (3H, t, J = 7.3 Hz).       1-563   8.31-8.28 (3H, m), 7.95-7.92 (3H, m), 7.62-7.60 (1H, m), 3.07-3.00 (1H, m), 2.93-2.87           (1H, m), 1.23 (3H, t, J = 7.3 Hz).       1-564   8.44 (2H, s), 7.86-7.83 (4H, m), 7.72-7.69 (2H, m), 7.64-7.61 (2H, m), 7.57-7.53 (1H, m),           7.44-7.40 (2H, m), 2.97-2.80 (2H, m), 1.13 (3H, t, J = 7.6 Hz).       1-565   8.43 (2H, s), 7.89-7.84 (3H, m), 7.76 (1H, d, J = 7.3 Hz), 7.72-7.69 (2H, m), 7.62-7.60 (1H,           m), 7.54-7.51 (1H, m), 7.36 (1H, t, J = 8.0 Hz), 2.93-2.81 (2H, m), 1.09 (3H, t, J = 7.3 Hz).       1-566   9.96 (1H, br), 8.42 (2H, s), 7.86-7.84 (2H, m), 7.70 (2H, d, J = 8.7 Hz), 7.74-7.71 (2H, m),           7.64-7.62 (1H, m), 7.36 (1H, d, J = 8.7 Hz), 2.89-2.80 (2H, m), 1.11 (3H, t, J = 7.3 Hz).           8.27 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.20 (2H, s), 7.96 (1H, s), 7.86 (1H, td, J1 = 7.7 Hz,       1-567   J2 = 1.1 Hz), 7.69 (1H, td, J1 = 7.7 Hz, J2 = 1.5 Hz), 7.35 (1H, dd, J1 = 7.8 Hz, J2 = 0.9 Hz),           3.51-3.42 (1H, m), 3.17-3.08 (1H, m), 2.61 (3H, s), 1.95 (3H, s), 1.43 (3H, t, J = 7.3 Hz).       1-569   9.21 (1H, br), 8.49 (1H, s), 7.91 (1H, s), 7.81 (1H, s), 7.75-7.73 (2H, m), 7.69-7.66 (1H,           m), 7.45-7.38 (2H, m), 7.36-7.32 (1H, m), 2.88-2.81 (1H, m), 2.79-2.71 (1H, m), 1.06 (3H,           t, J = 6.9 Hz).       1-572   8.27 (1H, dd, J1 = 7.8 Hz, J2 = 1.8 Hz), 8.22 (1H, s), 7.93-7.90 (2H, m), 7.85 (1H, td, J1 = 7.6           Hz, J2 = 1.7 Hz), 7.79 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz), 7.58 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz),           7.49-7.45 (2H, m), 7.41-7.36 (1H, m), 3.16 (2H, q, J = 7.3 Hz), 1.24 (3H, t, J = 7.3 Hz).       1-577   8.28 (1H, dd, J1 = 7.8 Hz, J2 = 1.8 Hz), 8.21 (1H, s), 7.93 (1H, t, J = 1.6 Hz), 7.85 (1H, td,           J1 = 7.7 Hz, J2 = 1.7 Hz), 7.82-7.77 (2H, m), 7.57 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.40 (1H,           t, J = 7.6 Hz), 7.35 (1H, dt, J1 = 8.4 Hz, J2 = 1.6 Hz), 3.16 (2H, q, J = 7.5 Hz), 1.24 (3H, t, J = 7.6           Hz).       1-578   8.27 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 8.20 (1H, s), 7.88-7.78 (4H, m), 7.57 (1H, dd, J1 = 7.3           Hz, J = 1.4 Hz), 7.46-7.43 (2H, m), 3.17 (2H, q, J = 7.5 Hz), 1.24 (1H, t, J = 7.6 Hz).       1-579   8.27 (1H, dd, J1 = 7.8 Hz, J2 = 1.8 Hz), 8.21 (1H, s), 8.09 (1H, t, J = 1.8 Hz), 7.87-7.78 (3H,           m), 7.56 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.51 (1H, dq, J1 = 7.9 Hz, J2 = 1.0 Hz), 7.33 (1H, t,           J = 7.8 Hz), 3.16 (2H, q, J = 7.5 Hz), 1.24 (3H, t, J = 7.3 Hz).       1-580   8.28 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.23 (1H, s), 7.88-7.79 (4H, m), 7.57 (1H, dd,           J1 = 7.3 Hz, J2 = 1.4 Hz), 7.49 (1H, t, J = 8.2 Hz), 7.25-7.22 (1H, m), 3.18 (2H, q, J = 7.5 Hz),           1.25 (3H, t, J = 7.3 Hz).       1-581   8.28 (1H, dd, J1 = 7.8 Hz, J2 = 1.8 Hz), 8.22 (1H, s), 8.02 (1H, d, J = 7.8 Hz), 7.86 (1H, td,           J1 = 7.6 Hz, J2 = 1.7 Hz), 7.83-7.78 (2H, m), 7.68 (1H, t, J = 7.3 Hz), 7.60 (1H, td, J1 = 7.8 Hz,           J2 = 1.4 Hz), 7.54 (1H, t, J = 7.6 Hz), 3.18 (2H, q, J = 7.5 Hz), 1.26 (3H, t, J = 7.6 Hz).       1-582   8.29-8.27 (2H, m), 8.20 (1H, s), 8.10 (1H, d, J = 7.3 Hz), 7.89-7.80 (2H, m), 7.65-7.57 (3H,           m), 3.19 (2H, q, J = 7.3 Hz), 1.25 (3H, t, J = 7.1 Hz).       1-583   8.29 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 8.11 (1H, s), 8.00 (1H, d, J = 7.3 Hz), 7.89 (1H, td,           J1 = 7.6 Hz, J2 = 1.8 Hz), 7.84 (1H, td, J1 = 7.6 Hz, J2 = 1.5 Hz), 7.66-7.59 (2H, m), 7.47 (1H,           dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 3.27 (2H, q, J = 7.5 Hz), 2.39 (3H, s), 1.26 (3H, t, J = 7.3 Hz).       1-584   8.29 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 8.12 (1H, s), 7.99 (1H, d, J = 7.3 Hz), 7.91-7.82 (2H,           m), 7.66-7.59 (2H, m), 7.50 (1H, dd, J1 = 7.3 Hz, J2 = 1.4 Hz), 3.32 (2H, br), 2.83 (2H, br),           1.26 (3H, t, J = 7.3 Hz), 1.11 (3H, t, J = 7.6 Hz).       1-585   8.37 (1H, s), 8.29-8.25 (2H, m), 7.94-7.85 (2H, m), 7.69-7.61 (2H, m), 7.54 (1H, dd,           J1 = 7.8 Hz, J2 = 1.4 Hz), 3.37 (2H, q, J = 7.5 Hz), 1.30 (3H, t, J = 7.3 Hz).       1-587   8.38 (1H, s), 8.28 (2H, d, J = 7.6 Hz, J2 = 1.6 Hz), 7.91 (1H, td, J1 = 7.6 Hz, J2 = 1.7 Hz), 7.86           (1H, td, J1 = 7.7 Hz, J2 = 1.7 Hz), 7.69 (1H, d, J = 7.8 Hz), 7.63 (1H, t, J = 7.8 Hz), 7.51 (1H,           dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 3.36 (2H, br), 1.29 (3H, t, J = 7.6 Hz).       1-594   8.43 (1H, d, J = 8.2 Hz), 8.31 (1H, s), 8.20 (1H, s), 8.10-8.06 (2H, m), 7.85 (1H, d, J = 1.4           Hz), 7.67-7.59 (2H, m), 3.24 (2H, q, J = 7.5 Hz), 1.28 (3H, t, J = 7.6 Hz).       1-596   8.28 (1H, dd, J1 = 7.3 Hz, J2 = 1.8 Hz), 8.28 (1H, s), 8.04 (2H, d, J = 8.2 Hz), 7.87 (1H, td,           J1 = 7.6 Hz, J2 = 1.8 Hz), 7.82 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz), 7.73 (2H, d, J = 7.8 Hz), 7.58           (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 3.17 (2H, q, J = 7.3 Hz), 1.28 (3H, t, J = 7.3 Hz).       1-609   8.27 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.20 (1H, s), 7.87-7.82 (3H, m), 7.79 (1H, td, J1 = 7.8           Hz, J2 = 1.4 Hz), 7.58 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.49 (2H, dt, J1 = 8.5 Hz, J2 = 2.1 Hz),           3.13 (2H, q, J = 7.5 Hz), 1.36 (9H, s), 1.26 (3H, t, J = 7.1 Hz).       1-610   8.28 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.26 (1H, s), 8.00 (2H, dt, J1 = 8.7 Hz, J2 = 1.8 Hz),           7.86 (1H, td, J1 = 7.6 Hz, J2 = 1.7 Hz), 7.80 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz), 7.71 (2H, dt,           J1 = 8.4 Hz, J2 = 1.9 Hz), 7.67-7.65 (2H, m), 7.59 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.49-7.45           (2H, m), 7.40-7.36 (1H, m), 3.17 (2H, q, J = 7.5 Hz), 1.25 (3H, t, J = 7.3 Hz).       1-611   8.27 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 8.17 (1H, s), 7.90-7.86 (2H, m), 7.85-7.83 (1H, m),           7.79 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz), 7.57 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.39-7.35 (2H,           m), 7.16-7.06 (5H, m), 3.17 (2H, q, J = 7.5 Hz), 1.24 (3H, t, J = 7.3 Hz).       1-612   8.29-8.27 (2H, m), 8.03 (2H, d, J = 8.7 Hz), 7.87 (1H, td, J1 = 7.6 Hz, J2 = 1.7 Hz), 7.83 (1H,           td, J1 = 7.7 Hz, J2 = 1.5 Hz), 7.76 (2H, d, J = 8.7 Hz), 7.57 (1H, dd, J1 = 7.3 Hz, J2 = 1.8           Hz).3.17 (2H, q, J = 7.5 Hz), 1.25 (3H, t, J = 7.5 Hz).       1-613   8.71 (1H, s), 8.51 (1H, d, J = 8.2 Hz), 8.28 (1H, dd, J1 = 7.8 Hz, J2 = 1.8 Hz), 7.88 (1H, td,           J1 = 7.6 Hz, J2 = 1.7 Hz), 7.82 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz), 7.77 (1H, s), 7.67 (1H, dd,           J1 = 8.2 Hz, J2 = 1.4 Hz), 7.61 (1H, dd, J1 = 7.3 Hz, J2 = 1.4 Hz), 3.23 (2H, q, J = 7.3 Hz), 1.27           (3H, t, J = 7.3 Hz).       1-631   8.37 (2H, s), 8.34 (1H, s), 8.29 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 7.88-7.83 (3H, m), 7.58           (1H, dd, J1 = 7.3 Hz, J2 = 1.8 Hz), 3.21 (2H, q, J = 7.5 Hz), 1.26 (3H, t, J = 7.3 Hz).       1-637   8.60 (2H, s), 8.29 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 7.95-7.86 (3H, m), 7.51 (1H, dd, J1 = 7.6           Hz, J2 = 1.6 Hz), 3.35 (2H, dd, J1 = 20.4 Hz, J2 = 7.1 Hz), 1.29 (3H, t, J = 7.6 Hz).       1-638   8.30 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 8.25 (2H, s), 7.93 (1H, td, J1 = 7.6 Hz, J2 = 1.7 Hz),           7.87 (1H, td, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.82 (1H, s), 7.55 (1H, dd, J1 = 7;.8 Hz, J2 = 1.4 Hz),           4.08 (2H, br), 3.20 (2H, q, J = 7.5 Hz), 1.27 (3H, t, J = 7.6 Hz).       1-639   8.50 (2H, s), 8.23 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 7.97 (1H, s), 7.89-7.85 (2H, m), 7.57           (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 4.19 (2H, q, J = 7.8 Hz), 3.10 (2H, q, J = 7.3 Hz), 1.24 (3H,           t, J = 7.8 Hz), 1.04 (3H, t, J = 7.3 Hz).       1-640   8.61 (2H, s), 8.32-8.30 (1H, m), 8.02 (1H, s), 8.00-7.93 (2H, m), 7.66-7.64 (1H, m), 3.35           (2H, q, J = 7.5 Hz), 1.33 (3H, t, J = 7.6 Hz).       1-641   8.37 (2H, s), 8.24 (1H, s), 7.87 (1H, s), 7.85 (1H, dd, J1 = 8.2 Hz, J2 = 1.4 Hz), 7.72 (1H, t,           J = 8.0 Hz), 7.43 (1H, dd, J1 = 8.0 Hz, J2 = 1.1 Hz), 3.57 (2H, q, J = 7.5 Hz), 1.41 (3H, t, J = 7.6           Hz).       1-642   8.36 (2H, s), 8.32 (1H, s), 8.26 (1H, d, J = 2.7 Hz), 7.89 (1H, s), 7.83 (1H, dd, J1 = 8.5 Hz,           J2 = 2.5 Hz), 7.52 (1H, d, J = 8.2 Hz), 3.21 (2H, q, J = 7.5 Hz), 1.29 (3H, t, J = 7.6 Hz).       1-643   8.38 (2H, s), 8.36 (1H, s), 8.21 (1H, d, J = 8.2 Hz), 7.91 (1H, s), 7.75 (1H, dd, J1 = 8.5 Hz,           J2 = 2.1 Hz), 7.60 (1H, d, J = 1.8 Hz), 3.38-3.29 (1H, m), 2.98-2.89 (1H, m), 1.38 (3H, t,           J = 7.3 Hz).       1-644   8.39 (2H, s), 8.24 (1H, s), 8.19 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.94 (1H, dd, J1 = 8.2 Hz,           J2 = 1.4 Hz), 7.89 (1H, s), 7.79 (1H, t, J = 8.0 Hz), 3.21 (2H, q, J = 7.5 Hz), 1.28 (3H, t, J = 7.3           Hz).       1-646   8.55 (1H, d, J = 1.8 Hz), 8.37 (3H, s), 8.14 (1H, dd, J1 = 8.0 Hz, J2 = 2.1 Hz), 7.90 (1H, s),           7.74 (1H, d, J = 8.2 Hz), 3.27 (2H, q, J = 7.5 Hz), 1.30 (3H, t, J = 7.3 Hz).       1-647   8.44 (1H, d, J = 8.2 Hz), 8.39 (1H, s), 8.38 (2H, br), 8.10 (1H, d, J = 8.2 Hz), 7.90 (1H, s),           7.85 (1H, s), 3.27 (2H, q, J = 7.3 Hz), 1.29 (3H, t, J = 7.6 Hz).       1-752   8.27-8.24 (3H, m), 8.09 (1H, s), 7.88-7.78 (2H, m), 7.75 (1H, s), 7.55 (1H, dd, J1 = 7.3 Hz,           J2 = 1.4 Hz), 3.18 (2H, q, J = 7.3 Hz), 1.24 (3H, t, J = 7.6 Hz).       1-765   8.70 (1H, s), 8.45 (1H, s), 8.34 (1H, s), 8.30 (1H, s), 8.28 (1H, dd, J1 = 8.0 Hz, J2 = 1.6 Hz),           7.88 (1H, td, J1 = 7.6 Hz, J2 = 1.8 Hz), 7.83 (1H, td, J1 = 7.7 Hz, J2 = 1.5 Hz), 7.58 (1H, dd,           J1 = 7.3 Hz, J2 = 1.4 Hz), 3.21 (2H, q, J = 7.5 Hz), 1.26 (3H, t, J = 7.6 Hz).       1-782   8.54 (1H, s), 8.33 (1H, s), 8.31 (1H, s), 8.26 (1H, dd, J1 = 8.0 Hz, J2 = 1.6 Hz), 8.15 (1H, s),           8.09 (1H, br), 7.87 (1H, td, J1 = 7.6 Hz, J2 = 1.8 Hz), 7.82 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz),           7.70 (2H, d, J = 7.8 Hz), 7.57 (1H, dd, J1 = 7.3 Hz, J2 = 1.4 Hz), 7.40 (2H, t, J = 7.8 Hz), 7.19           (1H, t, J = 7.1 Hz), 3.26 (2H, q, J = 7.3 Hz), 1.27 (3H, t, J = 7.6 Hz).       1-783   8.49 (1H, s), 8.32 (1H, s), 8.28 (1H, s), 8.25 (1H, dd, J1 = 7.8 Hz, J2 = 1.8 Hz), 8.17 (1H, br),           8.13 (1H, s), 7.87 (1H, td, J1 = 7.4 Hz, J2 = 1.7 Hz), 7.82 (1H, td, J1 = 7.7 Hz, J2 = 1.2 Hz),           7.69-7.65 (2H, m), 7.56 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.38-7.35 (2H, m), 3.27 (2H, q,           J = 7.5 Hz), 1.26 (3H, t, J = 7.3 Hz).       1-784   8.37 (2H, s), 8.36 (1H, s), 8.31 (1H, dd, J1 = 8.7 Hz, J2 = 5.5 Hz), 7.89 (1H, s), 7.53 (1H,           ddd, J1 = 9.4 Hz, J2 = 6.9 Hz, J3 = 2.1 Hz), 7.34 (1H, dd, J1 = 7.8 Hz, J2 = 2.7 Hz), 3.20 (2H, q,           J = 7.5 Hz), 1.27 (3H, t, J = 7.3 Hz).       1-785   8.37 (2H, s), 8.32 (1H, s), 8.14 (1H, d, J = 7.8 Hz), 7.87 (1H, s), 7.61 (1H, dd, J1 = 8.2 Hz,           J2 = 1.4 Hz), 7.38 (1H, d, J = 1.4 Hz), 3.16 (2H, q, J = 7.5 Hz), 2.56 (3H, s), 1.24 (3H, t, J = 7.5           Hz).       1-786   8.37 (2H, s), 8.34 (1H, s), 8.17 (1H, d, J = 8.7 Hz), 7.88 (1H, s), 7.25 (1H, dd, J1 = 9.2 Hz,           J2 = 2.7 Hz), 7.04 (1H, d, J = 2.3 Hz), 3.97 (3H, s), 3.15 (2H, q, J = 7.5 Hz), 1.24 (3H, t, J = 7.3           Hz).       1-787   8.75 (1H, s), 8.42 (1H, s), 8.24 (1H, s), 8.19 (1H, s), 7.91 (1H, s), 3.92 (2H, q, J = 7.5 Hz),           1.38 (3H, t, J = 7.6 Hz).       1-788   8.29 (1H, s), 8.28 (1H, d, J = 6.4 Hz), 8.06 (2H, d, J = 6.9 Hz), 7.87 (1H, t, J = 7.3 Hz), 7.82           (1H, t, J = 7.6 Hz), 7.72 (2H, d, J = 8.2 Hz), 7.58 (1H, d, J = 7.8 Hz), 3.15       1-790   8.37 (2H, s), 8.29 (1H, dd, J1 = 7.3 Hz, J2 = 1.8 Hz), 7.96-7.90 (2H, m), 7.88 (1H, s), 7.61           (1H, dd, J1 = 7.3 Hz, J2 = 1.8 Hz), 3.32 (2H, q, J = 7.5 Hz), 1.29 (3H, t, J = 7.6 Hz).       1-791   8.34 (1H, t, J = 1.8 Hz), 8.29 (1H, s), 8.23 (1H, dd, J1 = 7.8 Hz, J2 = 1.8 Hz), 7.99 (1H, d,           J = 7.8 Hz), 7.86-7.72 (3H, m), 7.57-7.52 (2H, m), 3.24 (2H, q, J = 7.5 Hz), 1.25 (3H, t, J = 7.3           Hz).       1-792   8.63 (1H, s), 8.38 (1H, s), 8.36 (1H, s), 8.26 (1H, dd, J1 = 7.8, J2 = 1.8 Hz), 8.19 (1H, s), 7.87           (1H, td, J1 = 7.7 Hz, J2 = 1.7 Hz), 7.82 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz), 7.58 (1H, dd, J1 = 7.3           Hz, J2 = 1.4 Hz), 3.25 (2H, q, J = 7.5 Hz), 2.72 (3H, s), 1.27 (3H, t, J = 7.3 Hz).       1-793   8.33 (2H, s), 8.32 (1H, s), 8.28 (1H, dd, J1 = 7.8 Hz, J2 = 1.8 Hz), 7.90-7.85 (2H, m), 7.83           (1H, td, J1 = 7.7 Hz, J2 = 1.5 Hz), 7.57 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 6.57 (1H, br), 3.22           (2H, q, J = 7.5 Hz), 2.96 (3H, d, J = 5.0 Hz), 1.27 (3H, t, J = 7.6 Hz).       1-794   8.24-8. 21 (1H, m), 8.20 (1H, s), 7.86-7.76 (4H, m), 7.53 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz),           7.33 (1H, t, J = 2.1 Hz), 3.16 (2H, qJ = 7.3 Hz), 1.22 (3H, t, J = 7.3 Hz)       1-795   8.42 (2H, d, J = 8.7 Hz), 8.36 (1H, s), 8.29 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 7.91-7.83 (3H,           m), 7.58 (1H, dd, J1 = 7.3 Hz, J2 = 1.8 Hz), 3.22 (2H, q, J = 7.5 Hz), 1.27 (3H, t, J = 7.3 Hz).       1-796   8.45 (2H, d, J = 6.4 Hz), 8.32 (1H, s), 8.26 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 8.03 (1H, s),           7.89-7.80 (4H, m), 7.65 (1H, tt, J1 = 7.3 Hz, J2 = 1.5 Hz), 7.58-7.52 (3H, m), 3.24 (2H, q,           J = 7.5 Hz), 1.26 (3H, t, J = 7.6 Hz).       1-797   8.37-8.25 (5H, m), 7.93 (1H, s), 7.86-7.81 (2H, m), 7.60 (2H, d, J = 7.8 Hz), 7.56 (1H, d,           J = 7.8 Hz), 7.36 (2H, q, J = 7.6 Hz), 7.19 (1H, q, J = 6.9 Hz), 3.27-3.20 (2H, m), 1.26 (3H, t,           J = 7.3 Hz).       1-798   8.32 (1H, s), 8.26 (1H, dd, J1 = 7.8 Hz, J2 = 1.8 Hz), 8.23 (2H, s), 7.86 (1H, td, J1 = 7.6 Hz,           J2 = 1.7 Hz), 7.81 (1H, td, J1 = 7.6 Hz, J2 = 1.5 Hz), 7.75 (1H, s), 7.57 (1H, dd, J1 = 7.3 Hz,           J2 = 1.4 Hz), 3.24 (2H, q, J = 7.3 Hz), 2.00 (3H, t, J = 18.3 Hz), 1.26 (3H, t, J = 7.6 Hz).       1-800   8.32 (1H, s), 8.31 (1H, s), 8.27 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 8.13 (1H, s), 7.88-7.78           (3H, m), 7.68-7.65 (2H, m), 7.58 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.51-7.47 (2H, m), 7.43-           7.40 (1H, m), 3.20 (2H, q, J = 7.5 Hz), 1.25 (3H, t, J = 7.3 Hz).       1-801   8.29-8.23 (2H, m), 7.91-7.81 (4H, m), 7.58-7.54 (1H, m), 7.32-7.30 (1H, m), 3.19 (2H, q,           J = 7.5 Hz), 2.05-1.98 (1H, m), 1.25 (3H, t, J = 7.3 Hz), 1.08-1.03 (2H, m), 0.84-0.79 (2H,           m).       1-802   8.45 (1H, d, J = 2.3 Hz), 8.37 (3H, s), 8.03 (1H, dd, J1 = 8.2 Hz, J2 = 2.3 Hz), 7.86 (1H, s),           7.70-7.67 (2H, m), 7.62 (1H, d, J = 8.2 Hz), 7.56-7.46 (3H, m), 3.25 (2H, q, J = 7.5 Hz), 1.29           (3H, t, J = 7.3 Hz).       1-803   8.38 (1H, s), 8.36 (1H, d, J = 2.3 Hz), 8.32 (2H, s), 7.98 (1H, dd, J1 = 8.0 Hz, J2 = 2.1 Hz),           7.83 (1H, s), 7.62-7.56 (3H, m), 7.47 (2H, d, J = 8.2 Hz), 3.29 (2H, q, J = 7.5 Hz), 1.29 (3H, t,           J = 7.3 Hz).       1-804   8.35 (2H, s), 8.28 (1H, s), 7.86 (1H, s), 7.81 (1H, d, J = 2.7 Hz), 7.48-7.44 (3H, m), 7.34-           7.24 (2H, m), 7.12 (2H, d, J = 7.8 Hz), 3.16 (2H, q, J = 7.5 Hz), 1.24 (3H, t, J = 7.6 Hz).       1-805   8.58 (1H, s), 8.38 (1H, s), 8.37 (2H, s), 8.15 (1H, d, J = 8.2 Hz), 7.91 (1H, s), 7.74 (1H, d,           J = 8.2 Hz), 3.29 (2H, q, J = 7.5 Hz), 1.31 (3H, t, J = 7.3 Hz).       1-806   8.35 (1H, d, J = 1.8 Hz), 8.32 (3H, br), 7.96 (1H, dd, J1 = 8.2 Hz, J2 = 2.3 Hz), 7.84 (1H, s),           7.42 (1H, d, J = 8.2 Hz), 3.23 (2H, q, J = 7.5 Hz), 1.27 (3H, t, J = 7.6 Hz).       1-808   8.63 (1H, d, J = 1.8 Hz), 8.43 (1H, s), 8.39-8.38 (3H, m), 7.91 (1H, s), 7.83 (1H, d, J = 8.2           Hz), 4.34 (3H, s), 3.33 (2H, q, J = 7.5 Hz), 1.32 (3H, t, J = 7.6 Hz).       1-809   9.02 (1H, d, J = 1.8 Hz), 8.64 (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz), 8.39 (3H, s), 7.89 (1H, s),           7.71 (1H, d, J = 8.2 Hz), 4.49 (3H, s), 3.28 (2H, q, J = 7.5 Hz), 1.32 (3H, t, J = 7.6 Hz).       1-810   8.35 (2H, s), 8.27 (1H, s), 7.89 (1H, d, J = 1.8 Hz), 7.85 (1H, s), 7.48-7.39 (2H, m), 3.15           (2H, q, J = 7.5 Hz), 2.14-2.06 (1H, m), 1.24 (3H, t, J = 7.3 Hz), 1.23-1.17 (2H, m), 0.90-0.85           (2H, m).       1-814   8.29 (1H, s), 8.13 (1H, dd, J = 7.8, 1.4 Hz), 7.97 (1H, s), 7.90 (1H, s), 7.78 (1H, td, J1 = 7.7           Hz, J2 = 1 5 Hz), 7.71 (1H, td, J1 = 7.6 Hz, J2 = 1.2 Hz), 7.51-7.48 (2H, m), 3.25 (2H, q, J = 7.3           Hz), 1.77 (2H, dd, J1 = 7.8 Hz, J2 = 5.5 Hz), 1.50 (2H, dd, J1 = 7.8 Hz, J2 = 5.5 Hz), 1.20 (3H,           t, J = 7.3 Hz).       1-815   8.96 (1H, s), 8.54 (1H, d, J = 8.2 Hz), 8.40 (1H, s), 8.38 (2H, s), 7.88 (1H, s), 7.69 (1H, d,           J = 8.2 Hz), 3.30 (2H, q, J = 7.5 Hz), 2.73 (3H, s), 1.31 (3H, t, J = 7.6 Hz).       1-816   8.33 (2H, s), 8.21 (1H, s), 7.83 (1H, s), 7.70 (1H, d, J = 2.3 Hz), 7.39-7.32 (2H, m), 7.30           (1H, s), 7.20-7.10 (3H, m), 6.62 (1H, s), 3.18 (2H, q, J = 7.5 Hz), 1.25 (3H, t, J = 7.6 Hz).       1-817   8.35 (2H, s), 8.27 (1H, s), 8.00 (1H, d, J = 1.8 Hz), 7.87 (1H, s), 7.59-7.58 (2H, m), 7.49-           7.48 (3H, m), 7.45 (1H, dd, J1 = 8.2 Hz, J2 = 2.3 Hz), 7.36 (1H, d, J = 8.2 Hz), 3.15 (2H, q,           J = 7.5 Hz), 1.23 (3H, t, J = 7.3 Hz).       1-818   8.42 (1H, d, J = 1.8 Hz), 8.34 (2H, s), 8.31 (1H, s), 8.23 (1H, dd, J1 = 8.0 Hz, J2 = 2.1 Hz),           7.88 (1H, s), 7.75-7.74 (2H, m), 7.69 (1H, d, J = 8.2 Hz), 7.56-7.56 (3H, m), 3.21 (2H, q,           J = 7.5 Hz), 1.21 (3H, t, J = 7.3 Hz).       1-819   8.78 (1H, d, J = 2.3 Hz), 8.42 (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz), 8.34 (2H, s), 8.32 (1H, s),           8.04 (2H, d, J = 7.8 Hz), 7.89 (1H, s), 7.72-7.69 (2H, m), 7.62 (2H, t, J = 7.6 Hz), 3.25 (2H, q,           J = 7.5 Hz), 1.27 (3H, t, J = 7.3 Hz).       1-820   8.89 (1H, d, J = 1.8 Hz), 8.52 (1H, dd, J1 = 8.5 Hz, J2 = 1.6 Hz), 8.37 (3H, s), 7.89 (1H, s),           7.67 (1H, d, J = 7.8 Hz), 4.51 (2H, d, J = 7.2 Hz), 3.27 (2H, q, J = 7.5 Hz), 1.47 (3H, t, J = 6.9           Hz), 1.30 (3H, t, J = 7.6 Hz).       1-821   1H-NMR (DMSO-D6) δ 9.45 (1H, s), 8.97 (1H, d, J = 5.0 Hz), 8.61 (2H, s), 8.58 (1H, d,           J = 1.8 Hz), 8.41 (1H, dd, J1 = 8.0 Hz, J2 = 2.1 Hz), 8.15 (1H, s), 8.00 (1H, d, J = 8.2 Hz), 3.51           (2H, q, J = 7.5 Hz), 2.86 (3H, d, J = 4.6 Hz), 1.18 (3H, t, J = 7.3 Hz).       1-823   8.37 (2H, s), 8.31 (1H, s), 7.96-7.94 (2H, m), 7.89 (1H, s), 7.59 (1H, d, J = 7.8 Hz), 3.20           (2H, q, J = 7.5 Hz), 2.01-1.98 (2H, m), 1.65-1.62 (2H, m), 1.27 (3H, t, J = 7.3 Hz).       1-825   8.36-8.33 (4H, m), 8.00 (1H, dd, J1 = 7.8 Hz, J2 = 1.8 Hz), 7.89 (1H, t, J = 7.8 Hz), 7.88 (1H,           s), 5.77 (1H, s), 3.13 (2H, q, J = 7.5 Hz), 2.75 (3H, d, J = 4.6 Hz), 1.26 (3H, t, J = 7.6 Hz).       1-827   8.52 (2H, s), 8.39 (1H, s), 8.37 (2H, s), 7.90 (1H, s), 3.16-3.07 (2H, m), 3.03-2.94 (2H, m),           1.28 (3H, t, J = 7.3 Hz).       1-828   8.79 (1H, s), 8.43 (1H, d, J = 8.2 Hz), 8.38 (3H, s), 7.90 (1H, s), 7.70 (1H, d, J = 7.8 Hz), 3.28           (2H, q, J = 7.5 Hz), 2.77 (3H, s), 1.30 (3H, t, J = 7.3 Hz).       1-829   8.64 (1H, s), 8.40-8.39 (3H, m), 8.28 (1H, d, J = 7.8 Hz), 7.91 (1H, s), 7.85 (1H, d, J = 8.2           Hz), 7.71 (1H, t, J = 7.8 Hz), 7.58 (1H, t, J = 7.6 Hz), 3.29 (2, q, J = 7.2 Hz), 1.31 (3H, t, J = 7.3           Hz).       1-830   8.71 (1H, dd, J1 = 6.6 Hz, J2 = 2.1 Hz), 8.39 (1H, d, J = 3.7 Hz), 8.28 (1H, dd, J1 = 7.6 Hz,           J2 = 1.6 Hz), 7.87 (1H, td, J1 = 7.7 Hz, J2 = 1.7 Hz), 7.82 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz),           7.65-7.61 (1H, m), 7.58 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 7.30 (1H, t, J = 9.4 Hz), 3.27 (2H,           q, J = 7.3 Hz), 1.28 (3H, t, J = 7.6 Hz).       1-831   8.99 (1H, d, J = 1.8 Hz), 8.55 (1H, dd, J1 = 8.0 Hz, J2 = 2.1 Hz), 8.38 (2H, s), 8.36 (1H, s),           8.15 (1H, s), 7.88 (1H, s), 7.63 (1H, d, J = 8.2 Hz), 4.04 (3H, s), 3.26 (2H, q, J = 7.3 Hz), 1.30           (3H, t, J = 7.3 Hz).       1-832   8.58 (1H, d, J = 1.8 Hz), 8.36 (2H, s), 8.31 (1H, s), 8.20 (1H, dd, J1 = 8.2 Hz, J2 = 2.3 Hz),           7.88 (1H, s), 7.28 (1H, d, J = 7.8 Hz), 3.21 (2H, q, J = 7.3 Hz), 1.28 (3H, t, J = 7.6 Hz).       1-833   8.37 (2H, s), 8.34 (1H, s), 8.12 (1H, d, J = 2.3 Hz), 7.90 (1H, s), 7.72-7.69 (1H, m), 7.65           (1H, d, J = 8.2 Hz), 3.23 (2H, q, J = 7.5 Hz), 1.29 (3H, t, J = 7.3 Hz).       1-834   8.74 (1H, s), 8.17 (1H, s), 8.14 (1H, s), 8.13 (2H, d, J = 7.8 Hz), 7.73 (2H, d, J = 8.2 Hz), 3.93           (2H, q, J = 7.5 Hz), 1.37 (3H, t, J = 7.6 Hz).       1-837   9.05 (1H, s), 8.59 (2H, s), 8.27 (1H, dd, J1 = 7.3 Hz, J2 = 2.3 Hz), 7.92 (1H, s), 7.90-7.82           (2H, m), 7.58 (1H, dd, J1 = 7.1 Hz, J2 = 1.6 Hz), 7.37 (2H, d, J = 7.8 Hz), 7.29-7.25 (2H, m),           7.11 (1H, d, J = 7.3 Hz), 3.54 (2H, dd, J1 = 27.2 Hz, J2 = 6.2 Hz), 1.39 (3H, t, J = 7.6 Hz).       1-838   9.15 (1H, s), 8.58 (2H, s), 8.28-8.26 (1H, m), 7.93 (1H, s), 7.91-7.83 (2H, m), 7.58-7.56           (1H, m), 7.36-7.32 (2H, m), 7.24-7.21 (2H, m), 3.54 (2H, dd, J1 = 26.3 Hz, J2 = 7.1 Hz), 1.39           (3H, t, J = 7.6 Hz).       1-839   8.50 (2H, s), 8.27-8.24 (1H, m), 7.92-7.85 (3H, m), 7.59-7.56 (1H, m), 7.00 (1H, br), 3.47           (2H, br), 2.74 (3H, d, J = 4.6 Hz), 1.35 (3H, t, J = 7.6 Hz).       1-840   8.29 (2H, s), 8.20 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 7.92 (1H, s), 7.90-7.79 (3H, m), 3.56           (2H, br), 2.99 (3H, s), 2.75 (3H, s), 1.36 (3H, t, J = 7.3 Hz).       1-841   8.37 (2H, s), 7.93 (1H, s), 7.82-7.74 (3H, m), 7.53-7.49 (1H, m), 2.92-2.80 (2H, m), 1.12           (3H, t, J = 7.3 Hz).       1-842   8.39 (2H, s), 8.31 (1H, s), 8.26 (1H, dd, J1 = 7.3 Hz, J2 = 1.8 Hz), 7.90-7.82 (3H, m), 7.72-           7.67 (3H, m), 7.57 (1H, t, J = 7.3 Hz), 7.45 (2H, t, J = 7.8 Hz), 3.06 (1H, br), 2.95 (1H, br),           1.25 (3H, t, J = 7.3 Hz).       1-843   8.36 (2H, s), 8.29-8.26 (2H, m), 7.91-7.83 (3H, m), 7.72 (1H, t, J = 1.8 Hz), 7.68-7.66 (1H,           m), 7.56-7.53 (2H, m), 7.39 (1H, t, J = 7.8 Hz), 3.05 (1H, br), 2.91 (1H, br), 1.25 (3H, t,           J = 7.6 Hz).       1-844   8.36 (2H, s), 8.33 (1H, s), 8.28-8.25 (1H, dd, J1 = 7.6 Hz, J2 = 2.1 Hz), 7.90-7.82 (3H, m),           7.67-7.65 (3H, m), 7.44-7.41 (2H, m), 3.05 (1H, br), 2.91 (1H, br), 1.25 (3H, t, J = 7.3 Hz).       1-845   8.32-8.27 (1H, m), 8.21 (2H, s), 7.94 (1H, m), 7.86-7.82 (1H, m), 7.55-7.51 (1H, m), 3.70           (2H, q, J = 7.3 Hz), 2.36 (6H, br), 1.39 (3H, t, J = 7.6 Hz).       1-847   8.45 (2H, s), 8.27 (1H, d, J = 7.3 Hz), 8.10 (1H, s), 7.94-7.86 (3H, m), 7.73 (1H, d, J = 6.9           Hz), 7.47-7.39 (2H, m), 7.36-7.31 (2H, m), 3.09-2.98 (2H, m), 1.24 (3H, t, J = 6.9 Hz).       1-853   8.21 (1H, d, J = 1.8 Hz), 8.20 (1H, s), 8.04 (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz), 7.81 (1H, d,           J = 1.8 Hz), 7.70 (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz), 7.60 (1H, d, J = 8.2 Hz), 7.23 (1H, d, J = 8.2           Hz), 2.85 (2H, q, J = 7.3 Hz), 1.26 (3H, t, J = 7.3 Hz).       1-855   8.22 (1H, d, J = 2.3 Hz), 8.20 (1H, s), 8.05 (1H, dd, J1 = 8.5 Hz, J2 = 2.1 Hz), 7.61 (1H, d,           J = 8.7 Hz), 7.55 (1H, d, J = 8.7 Hz), 7.31 (1H, d, J = 2.3 Hz), 7.23-7.19 (1H, m), 2.89 (2H, q,           J = 7.3 Hz), 1.30 (3H, t, J = 7.3 Hz).       1-860   8.52 (1H, d, J = 1.8 Hz), 8.22 (2H, s), 8.02 (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz), 7.63 (1H, d,           J = 8.2 Hz), 7.29 (1H, d, J = 7.8 Hz), 3.38-3.29 (1H, m), 2.96-2.88 (1H, m), 1.39 (3H, t, J = 7.6           Hz).       1-862   8.24 (1H, s), 8.23 (1H, d, J = 2.3 Hz), 8.11 (1H, d, J = 2.3 Hz), 8.03 (1H, dd, J1 = 8.2 Hz,           J2 = 2.3 Hz), 7.64 (1H, d, J = 8.2 Hz), 7.61 (1H, d, J = 8.7 Hz), 7.52 (1H, dd, J1 = 8.5 Hz,           J2 = 2.1 Hz), 3.38-3.29 (1H, m), 2.96-2.87 (1H, m), 1.36 (3H, t, J = 7.3 Hz).       1-867   8.57 (1H, d, J = 1.8 Hz), 8.24 (1H, d, J = 1.8 Hz), 8.23 (1H, s), 8.18 (1H, dd, J1 = 8.2 Hz,           J2 = 1.8 Hz), 8.00 (1H, dd, J1 = 8.5 Hz, J2 = 2.1 Hz), 7.61 (1H, d, J = 8.2 Hz), 7.27 (1H, d,           J = 8.7 Hz), 3.19 (2H, q, J = 7.5 Hz), 1.27 (3H, t, J = 7.6 Hz).       1-869   8.25-8.24 (2H, m), 8.11 (1H, d, J = 2.7 Hz), 8.01 (1H, dd, J1 = 8.2 Hz, J2 = 2.3 Hz), 7.71-7.68           (1H, m), 7.65-7.61 (2H, m), 3.20 (2H, q, J = 7.3 Hz), 1.27 (3H, t, J = 7.6 Hz).       2-14   8.62 (1H, d, J = 3.2 Hz), 8.52 (1H, s), 8.28 (1H, d, J = 7.8 Hz), 7.82 (1H, t, J = 7.8 Hz), 7.55-           7.47 (3H, m), 7.37 (1H, t, J = 7.6 Hz), 2.83 (2H, q, J = 7.3 Hz), 1.23 (3H, t, J = 7.3 Hz).       2-30   8.79 (1H, s), 7.98 (1H, s), 7.85 (1H, d, J = 1.4 Hz), 7.73 (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz),           7.27 (1H, d, J = 8.2 Hz), 2.88 (2H, q, J = 7.3 Hz), 1.27 (3H, t, J = 7.3 Hz).       2-32   8.80 (1H, s), 7.99 (1H, s), 7.59 (1H, d, J = 8.7 Hz), 7.34 (1H, d, J = 1.8 Hz), 7.25-7.22 (1H,           m), 2.92 (2H, q, J = 7.3 Hz), 1.30 (3H, t, J = 7.3 Hz).       2-33   8.88 (1H, s), 8.01 (1H, s), 7.90 (1H, d, J = 2.3 Hz), 7.79 (1H, dd, J1 = 8.7 Hz, J2 = 2.3 Hz),           7.71 (1H, d, J = 8.7 Hz), 2.95 (2H, q, J = 7.3 Hz), 1.30 (3H, t, J = 7.3 Hz).       2-90   8.93 (1H, dd, J1 = 4.6 Hz, J2 = 0.9 Hz), 8.42 (1H, s), 8.14 (1H, dd, J1 = 8.0 Hz, J2 = 1.1 Hz),           7.59-7.56 (2H, m), 7.51-7.44 (2H, m), 7.40 (1H, td, J1 = 7.7 Hz, J2 = 1.5 Hz), 2.78 (2H, q,           J = 7.5 Hz), 1.22 (3H, t, J = 7.3 Hz).       2-91   8.79 (1H, d, J = 5.0 Hz), 8.56 (1H, s), 8.52 (1H, s), 7.56-7.48 (3H, m), 7.47 (1H, d, J = 5.0           Hz), 7.39 (1H, td, J1 = 7.6 Hz, J2 = 1.5 Hz), 2.84 (2H, q, J = 7.5 Hz), 1.23 (3H, t, J = 7.3 Hz).       2-95   8.80 (1H, d, J = 5.0 Hz), 8.58 (1H, s), 8.52 (1H, s), 7.69 (1H, dd, J1 = 7.8 Hz, J2 = 1.8 Hz),           7.53 (1H, dd, J1 = 8.0 Hz, J2 = 1.6 Hz), 7.49-7.45 (2H, m), 2.68 (2H, q, J = 7.3 Hz), 1.05 (3H,           t, J = 7.3 Hz).       2-96   8.79 (1H, d, J = 5.0 Hz), 8.53 (1H, s), 8.51 (1H, s), 7.48-7.45 (3H, m), 7.34 (1H, dd, J1 = 8.5           Hz, J2 = 2.1 Hz), 2.88 (2H, q, J = 7.5 Hz), 1.27 (3H, t, J = 7.6 Hz).       2-97   8.80 (1H, d, J = 5.5 Hz), 8.59 (1H, s), 8.51 (1H, s), 7.59-7.58 (1H, m), 7.48-7.47 (3H, m),           2.82 (2H, q, J = 7.3 Hz), 1.22 (3H, t, J = 7.3 Hz).       2-98   8.79 (1H, d, J = 5.0 Hz), 8.55 (1H, s), 8.34 (1H, d, J = 8.7 Hz), 7.48-7.37 (4H, m), 2.89 (2H,           q, J = 7.5 Hz), 1.27 (3H, t, J = 7.3 Hz).       2-99   8.79 (1H, d, J = 5.5 Hz), 8.52 (1H, s), 8.50 (1H, s), 7.50-7.47 (2H, m), 7.19 (1H, dd, J1 = 9.2           Hz, J2 = 2.7 Hz), 7.05 (1H, ddd, J1 = 9.6 Hz, J2 = 6.9 Hz, J3 = 1.8 Hz), 2.88 (2H, q, J = 7.3 Hz),           1.29 (3H, t, J = 7.3 Hz)       2-100   8.79 (1H, d, J = 5.0 Hz), 8.54 (1H, s), 8.51 (1H, s), 7.63 (1H, s), 7.51-7.47 (2H, m), 7.39           (1H, d, J = 8.2 Hz), 2.88 (2H, q, J = 7.3 Hz), 1.27 (3H, t, J = 7.3 Hz).       2-102   8.79 (1H, d, J = 5.0 Hz), 8.54 (1H, s), 8.51 (1H, s), 7.82 (1H, d, J = 1.8 Hz), 7.70 (1H, dd,           J1 = 8.2 Hz, J2 = 1.8 Hz), 7.47 (1H, dd, j1 = 5.0 Hz, J2 = 1.4 Hz), 7.24 (1H, d, J = 8.2 Hz), 2.86           (2H, q, J = 7.3 Hz), 1.26 (3H, t, J = 7.3 Hz).       2-103   8.79 (1H, d, J = 5.0 Hz), 8.52-8.51 (2H, m), 7.46 (1H, d, J = 5.0 Hz), 7.40 (1H, d, J = 8.2 Hz),           7.35 (1H, s), 7.18 (1H, dd, J1 = 8.0 Hz, J2 = 1.1 Hz), 2.81 (2H, q, J = 7.3 Hz), 2.45 (3H, s),           1.22 (3H, t, J = 7.3 Hz).       2-104   8.81 (1H, d, J = 5.0 Hz), 8.64 (1H, s), 8.51 (1H, s), 7.75 (1H, d, J = 1.4 Hz), 7.69-7.63 (2H,           m), 7.49 (1H, dd, J1 = 5.5 Hz, J2 = 1.4 Hz), 2.94 (2H, q, J = 7.3 Hz), 1.31 (3H, t, J = 7.3 Hz).       2-107   8.80 (1H, d, J = 5.0 Hz), 8.62 (1H, s), 8.52 (1H, s), 7.74 (1H, s), 7.68 (1H, d, J = 8.2 Hz), 7.62           (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz), 7.49 (1H, d, J = 5.0 Hz), 2.93 (2H, q, J = 7.5 Hz), 1.29 (3H,           t, J = 7.3 Hz).       2-109   8.81 (1H, d, J = 5.0 Hz), 8.64 (1H, s), 8.52 (1H, s), 7.73 (1H, s), 7.70 (1H, d, J = 8.2 Hz), 7.61           (1H, d, J = 8.2 Hz), 7.49 (1H, d, J = 4.6 Hz), 2.91 (2H, q, J = 7.3 Hz), 1.28 (3H, t, J = 7.3 Hz).       2-110   8.80 (1H, d, J = 5.0 Hz), 8.62 (1H, s), 8.52 (1H, s), 7.63 (1H, d, J = 8.2 Hz), 7.56 (1H, s), 7.49           (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 7.44 (1H, dd, J1 = 8.2 Hz, J2 = 1.4 Hz), 4.25-4.13 (1H, m),           2.89 (2H, q, J = 7.5 Hz), 1.26 (3H, t, J = 7.3 Hz).       2-111   8.81 (1H, d, J = 5.0 Hz), 8.64 (1H, s), 8.52 (1H, s), 7.73 (1H, s), 7.67 (2H, d, J = 8.2 Hz), 7.60           (1H, d, J = 8.2 Hz), 7.49 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 3.58 (3H, s), 2.89 (2H, q, J = 7.3           Hz), 1.27 (3H, t, J = 7.3 Hz).       2-112   8.80 (1H, d, J = 5.5 Hz), 8.54 (1H, s), 8.52 (1H, d, J = 0.9 Hz), 7.56 (1H, d, J = 8.7 Hz), 7.48           (1H, dd, J1 = 5.3 Hz, J2 = 1.1 Hz), 7.31 (1H, d, J = 2.3 Hz), 7.21 (1H, ddd, J1 = 8.6 Hz, J2 = 1.2           Hz, J3 = 0.6 Hz), 2.90 (2H, q, J = 7.3 Hz), 1.29 (3H, t, J = 7.6 Hz).       2-113   8.80 (1H, d, J = 5.0 Hz), 8.61 (1H, s), 8.51 (1H, s), 7.76 (1H, s), 7.64 (1H, dd, J1 = 8.2 Hz,           J2 = 1.4 Hz), 7.60 (1H, d, J = 8.2 Hz), 7.48 (1H, d, J = 5.0 Hz), 2.92 (2H, q, J = 7.3 Hz), 1.28           (3H, t, J = 7.3 Hz).       2-118   8.81 (1H, d, J = 5.0 Hz), 8.63 (1H, s), 8.51 (1H, s), 7.87 (1H, d, J = 2.3 Hz), 7.76 (1H, dd,           J1 = 8.7 Hz, J2 = 2.3 Hz), 7.67 (1H, d, J = 8.7 Hz), 7.49 (1H, d, J = 4.1 Hz), 2.93 (2H, q, J = 7.3           Hz), 1.29 (3H, t, J = 7.3 Hz).       2-120   8.80 (1H, d, J = 5.0 Hz), 8.58 (1H, s), 8.50 (1H, s), 7.98 (1H, .$), 7.64 (1H, s), 7.48 (1H, d,           J = 5.0 Hz), 2.84 (2H, q, J = 7.5 Hz), 1.25 (3H, t, J = 7.3 Hz).       2-121   8.80 (1H, d, J = 5.0 Hz), 8.57 (1H, s), 8.51 (1H, s), 7.65 (1H, d, J = 8.2 Hz), 7.48 (2H, d,           J = 8.2 Hz), 2.69 (2H, q, J = 7.5 Hz), 1.06 (3H, t, J = 7.3 Hz).       2-122   8.80 (1H, d, J = 5.0 Hz), 8.57 (1H, s), 8.51 (1H, s), 7.82 (1H, d, J = 8.2 Hz), 7.48 (1H, dd,           J1 = 5.0 Hz, J2 = 0.9 Hz), 7.41 (1H, d, J = 8.7 Hz), 2.69 (2H, q, J = 7.5 Hz), 1.06 (3H, t, J = 7.3           Hz).       2-123   8.80 (1H, d, J = 5.0 Hz), 8.57 (1H, s), 8.51 (1H, d, J = 0.9 Hz), 7.56 (1H, d, J = 8.2 Hz), 7.50           (1H, d, J = 2.3 Hz), 7.48 (1H, dd, J1 = 5.5 Hz, J2 = 1.4 Hz), 7.33 (1H, dd, J1 = 8.0 Hz, J2 = 2.1           Hz), 3.87 (2H, s), 2.88 (2H, q, J = 7.3 Hz), 1.27 (3H, t? J = 7.3 Hz).       2-125   8.80 (1H, d, J = 5.0 Hz), 8.56 (1H, s), 8.52 (1H, s), 7.55 (1H, d, J = 1.8 Hz), 7.53 (1H, d,           J = 7.8 Hz), 7.47 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 7.39 (1H, dd, J1 = 8.0 Hz, J2 = 2.1 Hz), 4.65           (2H, s), 2.87 (2H, q, J = 7.5 Hz), 1.26 (3H, t, J = 7.3 Hz).       2-126   8.79 (1H, d, J = 5.0 Hz), 8.55 (1H, s), 8.52 (1H, s), 7.56 (1H, d, J = 1.4 Hz), 7.51 (1H, d,           J = 8.2 Hz), 7.47 (1H, dd, J1 = 5.0 Hz, J2 = 1.4 Hz), 7.36 (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz), 4.82           (2H, s), 2.86 (2H, q, J = 7.3 Hz), 1.91 (1H, br), 1.24 (3H, t, J = 7.6 Hz).       2-127   8.79 (1H, d, J = 5.0 Hz), 8.51 (1H, s), 7.46 (1H, dd, J1 = 5.3 Hz, J2 = 1.1 Hz), 7.40 (1H, d,           J = 7.8 Hz), 7.03 (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz), 2.80 (2H, q, J = 7.5 Hz), 2.01-1.95 (1H, m),           1.21 (3H, t, J = 7.3 Hz), 1.11-1.06 (2H, m), 0.81-0.77       2-128   8.79 (1H, d, J = 5.0 Hz), 8.56 (1H, s), 8.51 (1H, d, J = 0.9 Hz), 7.54 (1H, d, J = 2.3 Hz), 7.52           (1H, d, J = 8.2 Hz), 7.47 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 7.17 (1H, dd, J1 = 8.2 Hz, J2 = 1.8           Hz), 2.88 (2H, q, J = 7.5 Hz), 1.86 (2H, dd, J1 = 7.8 Hz, J2 = 5.0 Hz), 1.51 (2H, dd, J1 = 8.0 Hz,           J2 = 5.7 Hz), 1.26 (3H, t, J = 7.3 Hz).       2-129   8.80 (1H, d, J = 5.0 Hz), 8.61 (1H, s), 8.52 (1H, s), 8.28 (1H, d, J = 1.8 Hz), 8.13 (1H, s), 8.08           (1H, dd, J1 = 8.2 Hz, J2 = 1.4 Hz), 7.60 (1H, d, J = 8.2 Hz), 7.47 (1H, dd, J1 = 5.3 Hz, J2 = 1.1           Hz), 4.02 (3H, s), 2.96 (2H, q, J = 7.3 Hz), 1.28 (3H, t, J = 7.3 Hz).       2-131   8.78 (1H, d, J = 5.0 Hz), 8.61 (1H, s), 8.50 (1H, br), 8.21 (1H, d, J = 1.8 Hz), 8.06-8.02 (1H,           m), 7.64 (1H, d, J = 8.2 Hz), 7.46 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 2.95 (2H, q, J = 7.5 Hz),           2.68 (3H, s), 1.27 (3H, t, J = 7.3 Hz).       2-132   8.79 (1H, d, J = 5.0 Hz), 8.57 (1H, s), 8.51 (1H, d, J = 0.9 Hz), 7.58 (1H, d, J = 8.2 Hz), 7.56           (1H, d, J = 2.3 Hz), 7.48 (1H, dd, J1 = 5.3 Hz, J2 = 1.1 Hz), 7.43 (1H, dd, J1 = 8.2 Hz, J2 = 1.8           Hz), 5.93 (2H, s), 2.87 (2H, q, J = 7.5 Hz), 1.25 (3H, t, J = 7.3 Hz).           19F NMR: −63.48 (3F, s), −64.84 (3F, s).       2-134   8.80 (1H, d, J = 5.0 Hz), 8.57 (1H, s), 7.71 (1H, s), 7.63 (1H, d, J = 8.2 Hz), 7.48 (1H, d,           J = 8.2 Hz), 7.44 (1H, d, J = 4.1 Hz), 2.93 (2H, q, J = 7.3 Hz), 2.62 (3H, s), 1.29 (3H, t, J = 7.3           Hz).       2-135   8.80 (1H, d, J = 5.0 Hz), 8.57 (1H, s), 7.43 (1H, dd, J1 = 5.0 Hz, J2 = 1.4 Hz), 7.38 (1H, d,           J = 8.7 Hz), 7.30-7.28 (1H, m), 7.22-7.19 (1H, m), 2.89 (2H, q, J = 7.3 Hz), 2.61 (3H, s), 1.29           (3H, t, J = 7.6 Hz).       2-140   8.80 (1H, d, J = 5.0 Hz), 8.57 (1H, s), 8.51 (1H, s), 7.57-7.48 (3H, m), 7.45 (1H, dd, J1 = 5.3           Hz, J2 = 1.1 Hz), 7.39 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz), 2.84 (2H, q, J = 7.3 Hz), 1.24 (3H, t,           J = 7.3 Hz).       2-143   8.80 (1H, d, J = 5.0 Hz), 8.55 (1H, s), 8.50 (1H, s), 7.82 (1H, d, J = 1.8 Hz), 7.70 (1H, dd,           J1 = 8.2 Hz, J2 = 1.8 Hz), 7.46 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 7.24 (1H, d, J = 8.2 Hz), 2.86           (2H, q, J = 7.3 Hz), 1.26 (3H, t, J = 7.6 Hz).       2-145   8.81 (1H, d, J = 5.0 Hz), 8.55 (1H, s), 8.51 (1H, s), 7.55 (1H, d, J = 8.2 Hz), 7.47 (1H, dd,           J1 = 5.0 Hz, J2 = 1.4 Hz), 7.31 (1H, d, J = 2.3 Hz), 7.23-7.20 (1H, m),       2-147   8.87 (1H, d, J = 2.3 Hz)8.59 (1H, s), 8.40 (1H, d, J = 8.2 Hz), 8.05 (1H, dd, J1 = 8.2 Hz, J2 = 2.3           Hz), 7.56-7.48 (3H, m), 7.39 (1H, td, J1 = 7.6 Hz, J2 = 1.7 Hz), 2.85 (2H, q, J = 7.5 Hz), 1.24           (3H, t, J = 7.3 Hz).       2-148   8.57 (1H, s), 8.44 (1H, d, J = 8.2 Hz), 7.97 (1H, t, J = 7.6 Hz), 7.61 (1H, dd, J1 = 7.8 Hz,           J2 = 0.9 Hz), 7.54-7.46 (3H, m), 7.38-7.33 (1H, m), 2.84 (2H, q, J = 7.3 Hz), 1.23 (3H, t,           J = 7.3 Hz).       2-153   9.11 (1H, s), 8.66 (1H, d, J = 5.0 Hz), 8.30-8.25 (3H, m), 7.79 (1H, t, J = 7.6 Hz), 7.71 (1H, t,           J = 7.6 Hz), 7.56 (1H, d, J = 7.8 Hz), 7.44 (1H, dd, J1 = 8.0 Hz, J2 = 4.8 Hz), 3.38-3.28 (1H, m),           2.97-2.88 (1H, m), 1.37 (3H, t, J = 7.1 Hz).       2-169   8.81 (1H, s), 8.55 (1H, d, J = 1.8 Hz), 8.04 (1H, dd, J1 = 8.9 Hz, J2 = 2.5 Hz), 8.03 (1H, s),           7.31 (1H, d, J = 8.2 Hz), 3.42-3.33 (1H, m), 3.02-2.93 (1H, m), 1.40 (3H, t, J = 7.6 Hz).       2-171   8.83 (1H, s), 8.13 (1H, d, J = 2.3 Hz), 8.04 (1H, s), 7.67 (1H, d, J = 8.7 Hz), 7.55 (1H, dd,           J1 = 8.2 Hz, J2 = 2.3 Hz), 3.42-3.33 (1H, m), 3.02-2.93 (1H, m), 1.38 (3H, t, J = 7.3 Hz).       2-172   8.90 (1H, s), 8.68 (1H, d, J = 2.7 Hz), 8.10 (1H, dd, J1 = 8.7 Hz, J2 = 2.3 Hz), 8.05 (1H, s),           7.75 (1H, d, J = 8.2 Hz), 3.48-3.39 (1H, m), 3.07--2.98 (1H, m), 1.41 (3H, t, J = 7.3 Hz).       2-229   8.92 (1H, d, J = 4.6 Hz), 8.39 (1H, s), 8.25 (1H, d, J = 7.8 Hz), 8.17 (1H, d, J = 7.8 Hz), 7.78           (1H, t, J = 7.8 Hz), 7.69 (1H, t, J = 7.6 Hz), 7.57 (1H, d, J = 7.8 Hz), 7.50 (1H, dd, J1 = 8.0 Hz,           J2 = 4.8 Hz), 3.30 (1H, m), 2.90-2.81 (1H, m), 1.33 (3H, t, J = 7.3 Hz).       2-230   8.78 (1H, d, J = 5.0 Hz), 8.58 (1H, s), 8.46 (1H, s), 8.24 (1H, d, J = 7.8 Hz), 7.77-7.65 (2H,           m), 7.56-7.47 (2H, m), 3.36-3.26 (1H, m), 2.94-2.84 (1H, m), 1.35 (3H, t, J = 7.6 Hz).       2-234   8.79 (1H, d, J = 5.0 Hz), 8.51 (1H, s), 8.48 (1H, s), 7.67 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz),           7.60 (1H, t, J = 8.0 Hz), 7.48 (1H, dd, J1 = 5.5 Hz, J2 = 1.4 Hz), 7.41 (1H, dd, J1 = 7.8 Hz,           J2 = 1.4 Hz), 3.82-3.73 (1H, m), 3.37-3.28 (1H, m), 1.45 (3H, t, J = 7.6 Hz).       2-235   8.81 (1H, d, J = 5.5 Hz), 8.58 (1H, s), 8.48 (1H, s), 8.23 (1H, d, J = 2.3 Hz), 7.66 (1H, dd,           J1 = 8.5 Hz, J2 = 2.5 Hz), 7.53-7.51 (2H, m), 3.40-3.31 (1H, m), 2.97-2.88 (1H, m), 1.39 (3H,           t, J = 7.6 Hz).       2-236   8.81 (1H, d, J = 5.0 Hz), 8.62 (1H, s), 8.48 (1H, s), 8.21 (1H, d, J = 8.7 Hz), 7.74 (1H, dd,           J1 = 8.5 Hz, J2 = 2.1 Hz), 7.60 (1H, d, J = 1.8 Hz), 7.52 (1H, d, J = 5.0 Hz), 3.38-3.29 (1H, m),           2.96-2.88 (1H, m), 1.38 (3H, t, J = 7.6 Hz).       2-237   8.82 (1H, d, J = 5.0 Hz), 8.55 (1H, s), 8.50 (1H, s), 8.10-8.08 (1H, m), 7.78-7.76 (2H, m),           7.51 (1H, dd, J1 = 5.3 Hz, J2 = 1.1 Hz), 3.26-3.17 (1H, m), 2.91-2.82 (1H, m), 1.31 (3H, t,           J = 7.6 Hz).       2-238   8.81 (1H, d, J = 5.0 Hz), 8.56 (1H, s), 8.48 (1H, s), 7.97 (1H, dd, J1 = 8.2 Hz, J2 = 2.7 Hz),           7.57 (1H, dd, J1 = 8.7 Hz, J2 = 4.1 Hz), 7.52 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 7.38 (1H, ddd,           J1 = 9.4 Hz, J2 = 6.6 Hz, J3 = 2.1 Hz), 3.37-3.28 (1H, m), 2.94-2.85 (1H, m), 1.37 (3H, t,           J = 7.3 Hz).       2-239   8.78 (1H, d, J = 5.0 Hz), 8.58 (1H, s), 8.44 (1H, s), 8.33 (1H, d, J = 2.3 Hz), 7.78 (1H, dd,           J = 8.5, 2.1 Hz), 7.50-7.48 (1H, m), 7.43 (1H, d, J = 8.7 Hz), 3.37-3.28 (1H, m), 2.94-2.85           (1H, m), 1.36 (3H, t, J = 7.3 Hz).       2-241   8.81 (1H, d, J = 5.0 Hz), 8.58 (1H, s), 8.53 (1H, d, J = 2.3 Hz), 8.48 (1H, s), 8.02 (1H, dd,           J1 = 8.2 Hz, J2 = 1.8 Hz), 7.52 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 7.29 (1H, d, J = 8.7 Hz), 3.40-           3.32 (1H, m), 2.97-2.88 (1H, m), 1.40 (3H, t, J = 7.3 Hz).       2-242   8.80 (1H, d, J = 5.0 Hz), 8.55 (1H, s), 8.49 (1H, s), 8.03 (1H, s), 7.51-7.43 (3H, m), 3.36-           3.27 (1H, m), 2.94-2.85 (1H, m), 2.56 (3H, s), 1.37 (3H, t, J = 7.6 Hz).       2-243   8.83 (1H, d, J = 5.0 Hz), 8.69 (1H, s), 8.60 (1H, d, J = 2.3 Hz), 8.49 (1H, s), 7.98 (1H, dd,           J1 = 8.2 Hz, J2 = 1.8 Hz), 7.72 (1H, d, J = 8.2 Hz), 7.55 (1H, d, J = 5.5 Hz), 3.48-3.39 (1H, m),           3.01-2.93 (1H, m), 1.42 (3H, t, J = 7.3 Hz).       2-245   8.91 (1H, d, J = 1.8 Hz), 8.82 (1H, d, J = 5.0 Hz), 8.67 (1H, s), 8.49 (1H, s), 8.36 (1H, dd,           J1 = 8.2 Hz, J2 = 1.8 Hz), 7.66 (1H, d, J = 8.2 Hz), 7.53 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 4.48           (2H, q, J = 7.0 Hz), 3.45-3.36 (1H, m), 3.02-2.93 (1H, m), 1.47-1.42 (6H, m).       2-246   8.83 (1H, d, J = 5.0 Hz), 8.68 (1H, s), 8.58 (1H, d, J = 1.8 Hz), 8.49 (1H, s), 7.96 (1H, dd,           J1 = 8.2 Hz, J2 = 1.4 Hz), 7.73 (1H, d, J = 8.2 Hz), 7.54 (1H, dd, J1 = 5.0 Hz, J2 = 1.4 Hz), 3.46-           3.37 (1H, m), 3.00-2.91 (1H, m), 1.42 (3H, t, J = 7.6 Hz).       2-248   8.83 (1H, d, J = 5.0 Hz), 8.68 (1H, s), 8.56 (1H, d, J = 1.8 Hz), 8.50 (1H, s), 7.95 (1H, dd,           J1 = 8.2 Hz, J2 = 1.8 Hz), 7.75 (1H, d, J = 8.2 Hz), 7.54 (1H, d, J = 3.7 Hz), 3.44-3.35 (1H, m),           3.01-2.92 (1H, m), 1.37 (3H, t, J = 7.3 Hz).       2-249   8.82 (1H, d, J = 5.0 Hz), 8.67 (1H, s), 8.49 (1H, s), 8.29 (1H, d, J = 1.8 Hz), 7.83 (1H, d,           J = 8.2 Hz), 7.69 (1H, d, J = 8.2 Hz), 7.53 (1H, d, J = 4.1 Hz), 4.41-4.29 (1H, m), 3.43-3.34           (1H, m), 2.99-2.90 (1H, m), 1.36 (3H, t, J = 7.6 Hz).       2-250   8.83 (1H, d, J = 5.0 Hz), 8.68 (1H, s), 8.52-8.50 (2H, m), 7.92 (1H, d, J = 8.2 Hz), 7.71 (1H,           d, J = 8.2 Hz), 7.53 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 3.61 (3H, s), 3.43-3.34 (1H, m), 3.01-           2.02 (1H, m), 1.36 (3H, t, J = 7.3 Hz).       2-251   8.80 (1H, d, J = 5.0 Hz), 8.51 (1H, s), 8.48 (1H, s), 7.71 (1H, d, J = 2.7 Hz), 7.50 (1H, d,           J = 5.0 Hz), 7.46 (1H, d, J = 8.7 Hz), 7.16 (1H, dd, J1 = 8.7 Hz, J2 = 2.7 Hz), 3.98 (3H, s), 3.33-           3.24 (1H, m), 2.91-2.83 (1H, m), 1.35 (3H, t, J = 7.6 Hz).       2-252   8.82 (1H, d, J = 5.0 Hz), 8.60 (1H, s), 8.49 (1H, s), 7.63 (1H, d, J = 8.7 Hz), 7.54-7.51 (2H,           m), 3.40-3.31 (1H, m), 2.97-2.88 (1H, m), 1.38 (3H, t, J = 7.6 Hz).       2-253   8.82 (1H, d, J = 5.0 Hz), 8.66 (1H, s), 8.54 (1H, s), 8.49 (1H, s), 7.97 (1H, dd, J1 = 8.2 Hz,           J2 = 1.8 Hz), 7.65 (1H, d, J = 8.2 Hz), 7.53 (1H, d, J = 5.0 Hz), 3.44-3.36 (1H, m), 3.02-2.93           (1H, m), 1.40 (3H, t, J = 7.6 Hz).       2-258   8.83 (1H, d, J = 5.0 Hz), 8.68 (1H, s), 8.67 (1H, d, J = 2.3 Hz), 8.49 (1H, s), 8.08 (1H, dd,           J1 = 8.7 Hz, J2 = 2.3 Hz), 7.71 (1H, d, J = 8.7 Hz), 7.54 (1H, d, J = 5.0 Hz), 3.47-3.38 (1H, m),           3.02-2.93 (1H, m), 1.42 (3H, t, J = 7.3 Hz).       2-260   8.81 (1H, d, J = 5.0 Hz), 8.63-8.46 (3H, m), 7.68 (1H, s), 7.53 (1H, d, J = 4.1 Hz), 3.42-3.32           (1H, m), 2.97-2.88 (1H, m), 1.40 (3H, t, J = 7.3 Hz).       2-261   8.78 (1H, d, J = 5.0 Hz), 8.48 (1H, s), 8.47 (1H, s), 7.77 (1H, d, J = 8.7 Hz), 7.48 (1H, dd,           J1 = 5.0 Hz, J2 = 0.9 Hz), 7.37 (1H, d, J = 8.7 Hz), 3.85-3.76 (1H, m), 3.38-3.29 (1H, m), 1.46           (3H, t, J = 7.6 Hz).       2-262   8.78 (1H, d, J = 8.7 Hz), 8.48 (1H, s), 8, 47 (1H, s), 7.94 (1H, d, J = 8.2 Hz), 7.48 (1H, dd,           J1 = 5.0 Hz, J2 = 1.4 Hz), 7.29 (1H, d, J = 8.7 Hz), 3.84-3.75 (1H, m), 3.38-3.29 (1H, m), 1.46           (3H, t, J = 7.6 Hz).       2-263   8.82 (1H, d, J = 5.0 Hz), 8.62 (1H, s), 8.49 (1H, s), 8.18 (1H, d, J = 1.8 Hz), 7.76 (1H, dd,           J1 = 8.2 Hz, J2 = 2.3 Hz), 7.63 (1h, d, J = 7.8 Hz), 7.53 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 3.97           (2H, s), 3.43-3.33 (1H, m), 2.96-2.87 (1H, m), 1.40 (3H, t, J = 7.6 Hz).       2-267   8.80 (1H, d, J = 5.0 Hz), 8.53 (1H, s), 8.49 (1H, s), 7.91 (1H, d, J = 1.8 Hz), 7.50 (1H, dd,           J1 = 5.0 Hz, J2 = 1.4 Hz), 7.42 (1H, d, J = 7.8 Hz), 7.33 (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz), 3.34-           3.25 (1H, m), 2.92-2.83 (1H, m), 2.13-2.07 (1H, m), 1.36 (3H, t, J = 7.6 Hz), 1.17-1.13 (2H,           m), 0.92-0.83 (2H, m).       2-268   8.82 (1H, d, J = 5.0 Hz), 8.60 (1H, s), 8.49 (1H, s), 7.91 (1H, d, J = 2.3 Hz), 7.86 (1H, dd,           J1 = 8.2 Hz, J2 = 2.3 Hz), 7.59 (1H, d, J = 5.0 Hz), 7.52 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 3.39-           3.30 (1H, m), 2.92-2.83 (1H, m), 1.94-1.90 (2H, m), 1.65-1.61 (2H, m), 1.37 (3H, t, J = 7.3           Hz).       2-271   8.93 (1H, d, J = 1.8 Hz), 8.79 (1H, d, J = 5.0 Hz), 8.66 (1H, s), 8.46 (1H, s), 8.34 (1H, dd,           J = 8.2 Hz, 1.8 Hz), 7.67 (1H, d, J = 8.2 Hz), 7.49 (1H, d, J = 5.0 Hz), 3.43-3.33 (1H, m), 3.02-           2.92 (1H, m), 2.67 (3H, s), 1.40 (3H, t, J = 7.6 Hz).       2-272   8.81 (1H, d, J = 5.0 Hz), 8.62 (1H, s), 8.48 (1H, s), 8.38 (1H, d, J = 1.8 Hz), 7.71 (1H, dd,           J1 = 8.0 Hz, J2 = 2.1 Hz), 7.64 (1H, d, J = 7.8 Hz), 7.52 (1H, dd, J1 = 5.0 Hz, J2 = 1.4 Hz), 6.04           (2H, s), 3.43-3.34 (1H, m), 2.98-2.89 (1H, m), 1.38 (3H, t, J = 7.6 Hz).       2-275   8.82 (1H, d, J = 5.0 Hz), 8.53 (1H, s), 8.05 (1H, d, J = 1.8 Hz), 7.57-7.54 (1H, m), 7.49-7.46           (2H, m), 3.21-3.12 (1H, m), 2.86-2.77 (1H, m), 1.27 (3H, t, J = 7.6 Hz).       2-283   8.82 (1H, d, J = 5.0 Hz), 8.59 (1H, s), 8.53 (1H, d, J = 1.8 Hz), 8.46 (1H, s), 8.02 (1H, dd,           J1 = 8.2 Hz, J2 = 2.3 Hz), 7.50 (1H, d, J = 3.7 Hz), 7.29 (1H, d, J = 8.2 Hz), 3.41-3.32 (1H, m),           2.97-2.88 (1H, m), 1.40 (3H, t, J = 7.3 Hz).       2-285   8.83 (1H, d, J = 5.0 Hz), 8.61 (1H, s), 8.47 (1H, s), 8.12 (1H, d, J = 2.3 Hz), 7.63 (1H, d,           J = 8.7 Hz), 7.54-7.51 (2H, m), 3.41-3.32 (1H, m), 2.97-2.88 (1H, m), 1.38 (3H, t, J = 7.6           Hz).       2-288   8.65 (1H, s), 8.40 (1H, d, J = 8.2 Hz), 8.26-8.23 (1H, m), 8.00 (1H, t, J = 7.8 Hz), 7.78-7.73           (1H, m), 7.70-7.64 (2H, m), 7.59-7.56 (1H, m), 3.37-3.27 (1H, m), 2.95-2.86 (1H, m), 1.35           (3H, t, J = 7.6 Hz).       2-294   8.71 (1H, s), 8.69 (1H, s), 8.28 (1H, dd, J1 = 8.0 Hz, J2 = 1.6 Hz), 7.86 (1H, s), 7.80 (1H, td,           J1 = 7.6 Hz, J2 = 1.2 Hz), 7.71 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz), 7.60 (1H, dd, J1 = 7.8 Hz,           J2 = 1.4 Hz), 3.39-3.30 (1H, m), 2.98-2.90 (1H, m), 1.39 (3H, t, J = 7.3 Hz).       2-297   8.67 (1H, s), 8.62 (1H, s), 8.57 (1H, d, J = 2.3 Hz), 8.19 (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz),           7.83 (1H, s), 7.30-7.27 (1H, m), 3.36 (2H, q, J = 7.3 Hz), 1.32 (3H, t, J = 7.3 Hz).       2-299   8.68 (1H, s), 8.65 (1H, s), 8.12 (1H, d, J = 2.7 Hz), 7.84 (1H, s), 7.70 (1H, dd, J1 = 8.0 Hz,           J2 = 2.5 Hz), 7.65 (1H, d, J = 8.7 Hz), 3.38 (2H, q, J = 7.5 Hz), 1.32 (3H, t, J = 7.3 Hz).       2-309   8.77 (1H, s), 8.58 (1H, d, J = 1.8 Hz), 8.21 (1H, dd, J1 = 8.0 Hz, J2 = 2.1 Hz), 8.00 (1H, s),           7.30 (1H, d, J = 8.2 Hz), 3.32 (2H, q, J = 7.5 Hz), 1.31 (3H, t, J = 7.6 Hz).       2-311   8.80 (1H, s), 8.12 (1H, d, J = 2.7 Hz), 8.01 (1H, s), 7.73-7.70 (1H, m), 7.67 (1H, d, J = 8.7           Hz), 3.33 (2H, q, J = 7.5 Hz), 1.31 (3H, t, J = 7.3 Hz).       2-312   8.83 (1H, s), 8.67 (1H, d, J = 2.3 Hz), 8.27 (1H, dd, J1 = 8.5 Hz, J2 = 2.5 Hz), 8.02 (1H, s),           7.76 (1H, d, J = 8.7 Hz), 3.39 (2H, q, J = 7.5 Hz), 1.34 (3H, t, J = 7.3 Hz).       2-322   8.73 (1H, s), 8.52 (1H, s), 8.51 (1H, s), 8.39 (1H, d, J = 2.3 Hz), 7.98 (1H, dd, J1 = 8.5 Hz,           J2 = 2.1 Hz), 7.44 (1H, d, J = 8.7 Hz), 3.30 (2H, q, J = 7.5 Hz), 1.30 (3H, t, J = 7.3 Hz).       2-325   8.74 (1H, s), 8.54 (1H, s), 8.52 (1H, s), 8.11 (1H, d, J = 2.3 Hz), 7.70 (1H, dd, J1 = 8.9 Hz,           J2 = 2.1 Hz), 7.64 (1H, d, J = 8.7 Hz), 3.30 (2H, q, J = 7.5 Hz), 1.30 (3H, t, J = 7.6 Hz).       2-329   8.57 (1H, s), 8.40-8.39 (2H, m), 7.98 (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz), 7.52 (1H, s), 7.42           (1H, d, J = 8.2 Hz), 3.33 (2H, q, J = 7.3 Hz), 1.31 (3H, t, J = 7.3 Hz).       2-332   8.58 (1H, s), 8.39 (1H, s), 8.11 (1H, d, J = 2.3 Hz), 7.71-7.68 (1H, m), 7.62 (1H, d, J = 8.7           Hz), 7.53 (1H, s), 3.34 (2H, q, J = 7.5 Hz), 1.31 (3H, t, J = 7.6 Hz).       2-357   8.48 (1H, s), 8.40 (1H, d, J = 2.3 Hz), 8.03 (1H, s), 7.97 (1H, dd, J1 = 8.2 Hz, J2 = 2.3 Hz),           7.45 (1H, d, J = 8.2 Hz), 6.95 (1H, s), 4.01 (3H, s), 3.28 (2H, q, J = 7.3 Hz), 1.30 (3H, t, J = 7.6           Hz).       2-369   8.91 (1H, dd, J1 = 4.6 Hz, J2 = 0.9 Hz), 8.45 (1H, s), 8.28 (1H, dd, J1 = 7.8 Hz, J2 = 1.8 Hz),           8.16 (1H, dd, J1 = 8.0 Hz, J2 = 1.1 Hz), 7.86 (1H, td, J1 = 7.6 Hz, J2 = 1.7 Hz), 7.81 (1H, dd,           J1 = 7.7 Hz, J2 = 1.5 Hz), 7.61 (1H, dd, J1 = 7.3 Hz, J2 = 1.4 Hz), 7.48 (1H, dd, J1 = 8.0 Hz,           J2 = 4.8 Hz), 3.13 (1H, q, J = 7.5 Hz), 1.24 (3H, t, J = 7.6 Hz).       2-370   8.80 (1H, d, J = 5.0 Hz), 8.56 (1H, s), 8.48 (1H, s), 8.28 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz),           7.87 (1H, td, J1 = 7.6 Hz, J2 = 1.8 Hz), 7.82 (1H, td, J1 = 7.7 Hz, J2 = 1.5 Hz), 7.57 (1H, dd,           J1 = 7.6 Hz, J2 = 1.1 Hz), 7.49-7.48 (1H, m), 3.30 (2H, q, J = 7.5 Hz), 1.29 (3H, t, J = 7.3 Hz).       2-374   8.78 (1H, d, J = 5.0 Hz), 8.49 (1H, s), 8.48 (1H, s), 7.83 (1H, dd, J1 = 8.2 Hz, J2 = 1.4 Hz),           7.71 (1H, t, J = 8.0 Hz), 7.47 (1H, dd, J1 = 5.0 Hz, J2 = 1.4 Hz), 7.43 (1H, dd, J1 = 7.8 Hz,           J2 = 1.4 Hz), 3.60 (2H, q, J = 7.5 Hz), 1.43 (3H, t, J = 7.3 Hz).       2-375   8.80 (1H, d, J = 5.0 Hz), 8.54 (1H, s), 8.47 (1H, s), 8.25 (1H, d, J = 2.7 Hz), 7.82 (1H, dd,           J1 = 8.2 Hz, J2 = 2.3 Hz), 7.52 (1H, d, J = 8.2 Hz), 7.49 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 3.31           (2H, q, J = 7.5 Hz), 1.31 (3H, t, J = 7.6 Hz).       2-376   8.80 (1H, d, J = 5.0 Hz), 8.57 (1H, s), 8.47 (1H, s), 8.21 (1H, d, J = 8.7 Hz), 7.78 (1H, dd,           J1 = 8.5 Hz, J2 = 2.1 Hz), 7.59 (1H, d, J = 2.3 Hz), 7.49 (1H, dd, J1 = 5.3 Hz, J2 = 1.1 Hz), 3.30           (2H, q, J = 7.5 Hz), 1.29 (3H, t, J = 7.6 Hz).       2-377   8.80 (1H, d, J = 5.0 Hz), 8.51 (1H, s), 8.49 (1H, s), 8.18 (1H, dd, J1 = 8.0 Hz, J2 = 1.6 Hz),           7.93 (1H, dd, J1 = 8.2 Hz, J2 = 1.4 Hz), 7.77 (1H, t, J = 8.2 Hz), 7.49 (1H, dd, J1 = 5.0 Hz,           J2 = 1.4 Hz), 3.25 (2H, q, J = 7.5 Hz), 1.28 (3H, t, J = 7.3 Hz).       2-378   8.80 (1H, d, J = 5.5 Hz), 8.54 (1H, s), 8.47 (1H, s), 7.99 (1H, dd, J1 = 7.3 Hz, J2 = 2.7 Hz),           7.60-7.52 (2H, m), 7.49 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 3.29 (2H, q, J = 7.5 Hz), 1.30 (3H,           t, J = 7.6 Hz).       2-379   8.77 (1H, J = 5.0 Hz), 8.52 (1H, s), 8.45 (1H, s), 8.38 (1H, d, J = 2.3 Hz), 7.96 (1H, dd,           J1 = 8.2, J2 = 2.3 Hz), 7.48-7.46 (1H, m), 7.42 (1H, d, J = 8.2 Hz), 3.29 (2H, q, J = 7.5 Hz), 1.29           (3H, t, J = 7.3 Hz).       2-381   8.79 (1H, d, J = 5.0 Hz), 8.57 (1H, d, J = 1.8 Hz), 8.53 (1H, s), 8.46 (1H, s), 8.18 (1H, dd,           J1 = 8.2 Hz, J2 = 1.8 Hz), 7.49 (1H, dd, J1 = 5.0 Hz, J2 = 1.4 Hz), 7.28 (1H, d, J = 8.2 Hz), 3.31           (2H, q, J = 7.3 Hz), 1.30 (3H, t, J = 7.6 Hz).       2-382   8.79 (1H, d, J = 5.0 Hz), 8.52 (1H, s), 8.47 (1H, s), 8.06 (1H, d, J = 1.4 Hz), 7.63 (1H, dd,           J1 = 8.0 Hz, J2 = 1.6 Hz), 7.47 (1H, d, J = 5.0 Hz), 7.44 (1H, d, J = 8.2 Hz), 3.27 (2H, q, J = 7.5           Hz), 2.59 (3H, s), 1.28 (3H, t, J = 7.3 Hz).       2-383   8.81 (1H, d, J = 5.0 Hz), 8.61 (1H, s), 8.58 (1H, d, J = 1.8 Hz), 8.47 (1H, d, J = 0.9 Hz), 8.14           (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz), 7.73 (1H, d, J = 8.2 Hz), 7.51 (1H, dd, J1 = 5.3 Hz, J2 = 1.6           Hz), 3.40 (2H, q, J = 7.5 Hz), 1.33 (3H, t, J = 7.3 Hz).       2-384   8.79 (1H, d, J = 5.0 Hz), 8.50 (1H, s), 8.47 (1H, s), 7.84 (1H, br), 7.70 (1H, d, J = 2.7 Hz),           7.50 (1H, d, J = 5.0 Hz), 7.40 (1H, d, J = 8.7 Hz), 7.24 (1H, d, J = 3.2 Hz), 3.27 (2H, q, J = 7.5           Hz)1.27 (3H, t, J = 7.3 Hz).       2-385   8.89 (1H, d, J = 1.8 Hz), 8.80 (1H, d, J = 5.0 Hz), 8.60 (1H, s), 8.50 (1H, dd, J1 = 7.8 Hz,           J2 = 1.8 Hz), 8.48 (1H, s), 7.66 (1H, d, J = 7.6 Hz), 7.50 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 4.50           (2H, q, J = 7.2 Hz), 3.37 (2H, q, J = 7.5 Hz), 1.47 (3H, t, J = 7.1 Hz), 1.32 (3H, t, J = 7.3 Hz).       2-386   8.81 (1H, d, J = 5.0 Hz), 8.61 (1H, s), 8.55 (1H, d, J = 1.8 Hz), 8.48 (1H, s), 8.13 (1H, dd,           J1 = 8.2 Hz, J2 = 1.8 Hz), 7.74 (1H, d, J = 8.2 Hz), 7.51 (1H, dd, J1 = 5.0 Hz, J2 = 1.4 Hz), 3.37           (2H, q, J = 7.5 Hz), 1.32 (3H, t, J = 7.6 Hz).       2-387   9.14 (1H, m), 8.90-8.87 (2H, m), 8.62 (1H, s), 8.32 (1H, s), 7.57 (1H, dd, J1 = 5.0 Hz,           J2 = 0.9 Hz), 3.99 (2H, q, J = 7.5 Hz), 1.50 (3H, t, J = 7.6 Hz).       2-388   8.81 (1H, d, J = 5.0 Hz), 8.63 (1H, s), 8.53 (1H, d, J = 2.3 Hz), 8.49 (1H, s), 8.12 (1H, dd,           J1 = 8.0 Hz, J2 = 1.6 Hz), 7.76 (1H, d, J = 8.2 Hz), 7.52-7.50 (1H, m), 3.38 (2H, q, J = 7.3 Hz),           1.30 (3H, t, J = 7.3 Hz).       2-389   8.81 (1H, d, J = 5.0 Hz), 8.61 (1H, s), 8.48 (1H, s), 8.31 (1H, d, J = 2.3 Hz), 7.98 (1H, dd,           J1 = 8.2 Hz, J2 = 1.4 Hz), 7.69 (1H, d, J = 8.2 Hz), 7.50 (1H, dd, J1 = 5.0 Hz, J2 = 1.4 Hz), 4.41-           4.29 (1H, m), 3.35 (2H, q, J = 7.5 Hz), 1.29 (3H, t, J = 7.3 Hz).       2-390   8.81 (1H, d, J = 5.0 Hz), 8.61 (1H, s), 8.50 (2H, dd, J1 = 8.2 Hz, J2 = 1.4 Hz), 8.09 (1H, dd,           J1 = 8.2 Hz, J2 = 1.4 Hz), 7.71 (1H, d, J = 8.7 Hz), 7.50 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 3.64           (3H, s), 3.37 (2H, q, J = 7.5 Hz), 1.30 (3H, t, J = 7.6 Hz).       2-391   8.79 (1H, s), 8.51 (1H, s), 8.47 (1H, s), 7.73 (1H, d, J = 3.2 Hz), 7.48-7.46 (2H, m), 7.29           (1H, dd, J1 = 8.7 Hz, J2 = 3.2 Hz), 3.98 (3H, s), 3.24 (2H, q, J = 7.5 Hz), 1.28 (3H, t, J = 7.3           Hz).       2-392   8.80 (1H, d, J = 5.0 Hz), 8.56 (1H, s), 8.47 (1H, s), 8.12 (1H, d, J = 2.7 Hz), 7.71-7.68 (1H,           m), 7.64 (1H, d, J = 8.7 Hz), 7.50 (1H, dd, J1 = 5.0 Hz, J2 = 1.4 Hz), 3.32 (2H, q, J = 7.5 Hz),           1.30 (3H, t, J = 7.6 Hz).       2-393   8.80 (1H, d, J = 5.0 Hz), 8.60 (1H, d, J = 0.9 Hz), 8.53 (1H, d, J = 1.8 Hz), 8.48 (1H, s), 8.13           (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz), 7.64 (1H, d, J = 7.3 Hz), 7.50 (1H, d, J = 4.6 Hz), 3.36 (2H,           q, J = 7.5 Hz), 1.31 (3H, t, J = 7.6 Hz).       2-394   8.79 (1H, d, J = 5.0 Hz), 8.52 (1H, s), 8.47 (1H, s), 8.02 (1H, d, J = 2.3 Hz), 7.60 (1H, dd,           J1 = 8.2 Hz, J2 = 2.3 Hz), 7.48 (1H, d, J = 5.0 Hz), 7.43 (1H, d, J = 8.2 Hz), 3.27 (2H, q, J = 7.5           Hz), 2.62 (3H, s), 1.29 (3H, t, J = 7.6 Hz).       2-395   8.81 (1H, d, J = 5.0 Hz), 8.60 (1H, s), 8.48 (1H, s), 8.42 (1H, d, J = 1.8 Hz), 8.25 (1H, m, dd,           J1 = 8.2 Hz, J2 = 1.8 Hz), 7.78 (1H, d, J = 8.2 Hz), 7.50 (1H, d, J = 3.7 Hz), 3.36 (2H, q, J = 7.2           Hz), 2.89 (3H, s), 1.32 (3H, t, J = 7.3 Hz).       2-396   8.83-8.80 (2H, m), 8.62 (1H, s), 8.49 (1H, s), 8.44 (1H, d, J1 = 8.0 Hz, J2 = 2.1 Hz), 7.80           (1H, d, J = 7.8 Hz), 7.52 (1H, d, J = 3.7 Hz), 3.42 (2H, q, J = 7.5 Hz), 3.22 (3H, s), 1.35 (3H, t,           J = 7.3 Hz).       2-397   8.80 (1H, d, J = 5.0 Hz), 8.59 (1H, s), 8.47 (1H, s), 8.18 (1H, d, J = 2.7 Hz), 7.79 (1H, dd,           J1 = 8.7 Hz, J2 = 2.7 Hz), 7.71 (1H, d, J = 8.2 Hz), 7.51 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 3.36           (2H, q, J = 7.5 Hz), 1.31 (3H, t, J = 7.6 Hz).       2-398   8.81 (1H, d, J = 5.0 Hz), 8.66 (1H, d, J = 2.7 Hz), 8.60 (1H, s), 8.48 (1H, s), 8.24 (1H, dd,           J1 = 8.7 Hz, J2 = 2.7 Hz), 7.72 (1H, d, J = 8.7 Hz), 7.51 (1H, d, J = 6.0 Hz), 3.39 (2H, q, J = 7.5           Hz), 1.33 (3H, t, J = 7.3 Hz).       2-399   8.79 (1H, d, J = 5.0 Hz), 8.51 (1H, s), 8.47 (1H, s), 7.87 (1H, dd, J1 = 2.3 Hz, J2 = 0.9 Hz),           7.48-7.46 (3H, m), 5.33 (2H, s), 3.54 (3H, s), 3.25 (2H, q, J = 7.5 Hz), 1.28 (3H, t, J = 7.3           Hz).       2-400   8.79 (1H, d, J = 5.0 Hz), 8.68 (1H, s), 8.56 (1H, s), 8.45 (1H, s), 7.64 (1H, s), 7.49 (1H, d,           J = 4.6 Hz), 3.31 (2H, q, J = 7.5 Hz), 1.31 (3H, t, J = 7.3 Hz).       2-401   8.78 (1H, d, J = 5.5 Hz), 8.48 (1H, s), 8.47 (1H, s), 7.91 (1H, d, J = 8.2 Hz), 7.48 (1H, d,           J = 5.0 Hz), 7.39 (1H, d, J = 8.7 Hz), 3.63 (2H, q, J = 7.5 Hz), 1.44 (3H, t, J = 7.6 Hz).       2-402   8.78 (1H, d, J = 5.0 Hz), 8.48 (1H, s), 8.47 (1H, s), 8.09 (1H, d, J = 8.2 Hz), 7.48 (1H, dd,           J1 = 5.3 Hz, J2 = 1.6 Hz), 7.31 (1H, d, J = 8.7 Hz), 3.63 (2H, q, J = 7.5 Hz), 1.44 (3H, t, J = 7.3           Hz).       2-403   8.80 (1H, d, J = 5.0 Hz), 8.56 (1H, s), 8.47 (1H, s), 8.21 (1H, d, J = 2.3 Hz), 7.91 (1H, dd,           J1 = 8.0 Hz, J2 = 2.1 Hz), 7.63 (1H, d, J = 8.0 Hz), 7.49 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 4.00           (2H, s), 3.32 (2H, q, J = 7.3 Hz), 1.30 (3H, t, J = 7.3 Hz).       2-404   8.81 (1H, d, J = 5.0 Hz), 8.63 (1H, s), 8.59-8.57 (1H, m), 8.48 (1H, s), 8.18 (1H, dd, J1 = 8.2           Hz, J2 = 2.3 Hz), 7.80 (1H, d, J = 8.2 Hz), 7.51 (1H, d, J = 5.0 Hz), 3.39 (2H, q, J = 7.5 Hz),           1.34 (3H, t, J = 7.3 Hz).       2-407   8.79 (1H, d, J = 5.0 Hz), 8.51 (1H, s), 8.47 (1H, s), 7.91 (1H, s), 7.48-7.47 (2H, m), 7.41           (1H, d, J = 8.2 Hz), 3.26 (2H, d, J = 7.0 Hz), 2.14-2.08 (1H, m), 1.28 (3H, t, J = 7.3 Hz), 1.23-           1.18 (2H, m), 0.91-0.87 (2H, m).       2-408   8.80 (1H, d, J = 5.0 Hz), 8.54 (1H, s), 8.47 (1H, s), 7.97 (1H, s), 7.93 (1H, d, J = 8.2 Hz), 7.58           (1H, d, J = 8.2 Hz), 7.49 (1H, d, J = 5.0 Hz), 3.29 (2H, q, J = 7.5 Hz), 1.29 (3H, t, J = 7.6 Hz).       2-409   8.98 (1H, d, J = 1.8 Hz), 8.80 (1H, d, J = 5.0 Hz), 8.59 (1H, s), 8.54 (1H, dd, J1 = 8.2 Hz,           J2 = 1.8 Hz), 8.48 (1H, s), 8.15 (1H, s), 7.62 (1H, d, J = 7.8 Hz), 7.48 (1H, dd, J1 = 5.0 Hz,           J2 = 1.4 Hz), 4.04 (3H, s), 3.35 (2H, q, J = 7.5 Hz), 1.33 (3H, t, J = 7.3 Hz).       2-410   9.01 (1H, d, J = 2.3 Hz), 8.80 (1H, d, J = 5.0 Hz), 8.64-8.62 (2H, m), 8.48 (1H, s), 7.71 (1H,           d, J = 8.2 Hz), 7.49 (1H, d, J = 5.0 Hz), 4.48 (3H, s), 3.38 (2H, q, J = 7.5 Hz), 1.34 (3H, t,           J = 7.6 Hz).       2-411   8.90 (1H, d, J = 1.8 Hz), 8.76 (1H, d, J = 5.0 Hz), 8.59 (1H, s), 8.49 (1H, dd, J1 = 8.2 Hz,           J2 = 1.8 Hz), 8.43 (1H, s), 7.66 (1H, d, J = 8.2 Hz), 7.45 (1H, dd, J = 4.1 Hz), 3.35 (2H, q,           J = 7.3 Hz), 2.69 (3H, s), 1.30 (3H, t, J = 7.3 Hz).       2-412   8.80 (1H, d, J = 5.0 Hz), 8.56 (1H, s), 8.47 (1H, d, J = 0.9 Hz), 8.37 (1H, d, J = 2.3 Hz), 7.89           (1H, dd, J1 = 8.2 Hz, J2 = 2.3 Hz), 7.64 (1H, d, J = 8.2 Hz), 7.49 (1H, dd, J1 = 5.3 Hz, J2 = 1.1           Hz), 6.05 (2H, s), 3.33 (2H, q, J = 7.3 Hz), 1.29 (3H, t, J = 7.6 Hz).       2-414   8.55-8.52 (1H, m), 8.81 (1H, d, J = 5.0 Hz), 8.15 (1H, dd, J1 = 8.2 Hz, J2 = 1.4 Hz), 7.63 (1H,           d, J = 8.2 Hz), 7.45 (1H, dd, J1 = 5.0 Hz, J2 = 1.4 Hz), 3.38 (2H, q, J = 7.3 Hz), 2.64 (3H, s),           1.31 (3H, t, J = 7.3 Hz).       2-415   8.80 (1H, d, J = 5.0 Hz), 8.51 (1H, s), 8.12 (1H, d, J = 2.3 Hz), 7.73-7.70 (1H, m), 7.54 (1H,           d, J = 8.7 Hz), 7.44 (1H, dd, J1 = 5.0 Hz, J2 = 0.9 Hz), 3.35 (2H, q, J = 7.3 Hz), 1.30 (3H, t,           J = 7.3 Hz).       2-416   8.82 (1H, d, J = 5.0 Hz), 8.55 (1H, d, J = 0.9 Hz), 8.07 (1H, d, J = 2.3 Hz), 7.74 (1H, d, J = 8.7 Hz),           7.70-7.67 (1H, m), 7.48 (1H, dd, J1 = 5.3 Hz, J2 = 1.1 Hz), 4.97 (2H, br), 3.39 (2H, q, J = 7.5 Hz),           3.31 (3H, s), 1.31 (3H, t, J = 7.3 Hz).       2-420   8.80 (1H, d, J = 5.5 Hz), 8.57 (1H, s), 8.47 (1H, s), 8.28 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 7.87           (1H, td, J1 = 7.6 Hz, J2 = 1.8 Hz), 7.82 (1H, td, J1 = 7.7 Hz, J2 = 1.7 Hz), 7.57 (1H, dd, J1 = 7.3 Hz,           J2 = 1.4 Hz), 7.47 (1H, d, J = 5.0 Hz), 3.31 (2H, q, J = 7.5 Hz), 1.29 (3H, t, J = 7.6 Hz).       2-423   8.80 (1H, d, J = 5.0 Hz), 8.57 (1H, d, J = 1.8 Hz), 8.54 (1H, s), 8.45 (1H, s), 8.18 (1H, dd, J1 = 8.2           Hz, J2 = 1.8 Hz), 7.47 (1H, d, J = 3.7 Hz), 7.27 (1H, d, J = 8.2 Hz), 3.31 (2H, q, J = 7.5 Hz), 1.30           (3H, t, J = 7.6 Hz).       2-425   8.81 (1H, d, J = 5.0 Hz), 8.57 (1H, s), 8.46 (1H, s), 8.12 (1H, d, J = 2.3 Hz), 7.69 (1H, dd, J1 = 8.5           Hz, J2 = 1.6 Hz), 7.63 (1H, d, J = 8.7 Hz), 7.48 (1H, d, J = 5.0 Hz), 3.32 (2H, q, J = 7.5 Hz), 1.31           (3H, t, J = 7.6 Hz).       2-427   8.87 (1H, d, J = 2.3 Hz), 8.59 (1H, s), 8.36 (1H, d, J = 8.2 Hz), 8.28 (1H, dd, J1 = 7.6 Hz, J2 = 1.6           Hz), 8.06 (1H, dd, J1 = 8.5 Hz, J2 = 2.1 Hz), 7.87 (1H, td, J1 = 7.7 Hz, J2 = 1.7 Hz), 7.82 (1H, td,           J1 = 7.6 Hz, J2 = 1.6 Hz), 7.57 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 3.31 (2H, q, J = 7.5 Hz), 1.28 (3H,           t, J = 7.6 Hz).       2-428   8.59 (1H, s), 8.39 (1H, d, J = 8.2 Hz), 8.24 (1H, dd, J1 = 7.6 Hz, J2 = 1.6 Hz), 7.97 (1H, t, J = 7.8           Hz), 7.86-7.76 (2H, m), 7.62 (1H, d, J = 6.9 Hz), 7.55 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 3.35 (2H,           q, J = 7.5 Hz), 1.27 (3H, t, J = 7.6 Hz).       2-434   8.87 (1H, d, J = 1.8 Hz), 8.60 (1H, s), 8.40 (1H, d, J = 8.2 Hz), 8.05 (1H, dd, J1 = 8.2 Hz, J2 = 2.3           Hz), 7.57-7.48 (3H, m), 7.38 (1H, dd, J1 = 7.6 Hz, J2 = 1.4 Hz), 2.78 (2H, t, J = 7.3 Hz), 1.58 (2H,           sext, J = 7.3 Hz), 0.94 (3H, t, J = 7.3 Hz).       2-445   8.89 (1H, d, J = 2.3 Hz), 8.63 (1H, s), 8.37 (1H, d, J = 8.2 Hz), 8.29 (1H, dd, J1 = 7.8 Hz, J2 = 1.4           Hz), 7.78 (1H, td, J1 = 7.7 Hz, J2 = 1.2 Hz), 7.70 (1H, td, J1 = 7.7 Hz, J2 = 1.7 Hz), 7.57 (1H, dd,           J1 = 7.8 Hz, J2 = 0.9 Hz), 3.30-3.23 (1H, m), 2.91-2.84 (1H, m), 2.06-1.93 (1H, m), 1.93-1.77           (1H, m), 1.09 (3H, t, J = 7.3 Hz).       2-447   8.88 (1H, s), 8.59 (1H, s), 8.36 (1H, d, J = 8.2 Hz), 8.27 (1H, dd, J1 = 7.8 Hz, J2 = 1.8 Hz), 8.06           (1H, dd, J1 = 8.2 Hz, J2 = 2.3 Hz), 7.86 (1H, td, J1 = 7.6 Hz, J2 = 1.7 Hz), 7.82 (1H, td, J1 = 7.7 Hz,           J2 = 1.5 Hz), 7.57 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 3.25 (2H, t, J = 7.8 Hz), 1.74 (2H, sext, J = 7.8           Hz), 1.00 (3H, t, J = 7.3 Hz).       2-484   8.88 (1H, s), 8.56 (1H, s), 8.40 (1H, d, J = 8.2 Hz), 8.07 (1H, dd, J1 = 8.2 Hz, J2 = 2.3 Hz), 7.82-           7.80 (1H, m), 7.58-7.56 (3H, m), 3.34 (2H, q, J = 9.5 Hz).       2-485   8.90 (1H, dd, J1 = 2.3 Hz, J2 = 0.9 Hz), 8.70 (1H, s), 8.44 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 8.40           (1H, d, J = 8.2 Hz), 8.09 (1H, dd, J1 = 8.2 Hz, J2 = 1.8 Hz), 7.84 (1H, td, J1 = 7.7 Hz, J2 = 1.5 Hz),           7.79 (1H, td, J1 = 7.6 Hz, J2 = 1.7 Hz), 7.64 (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 4.37-4.26 (1H, m),           3.64-3.53 (1H, m).       3-14   9.10 (1H, d, J = 2.3 Hz), 8.62 (1H, d, J = 5.0 Hz), 8.31 (1H, d, J = 8.2 Hz), 8.26 (1H, s), 7.56-7.48           (3H, m), 7.43-7.37 (2H, m), 2.84 (2H, q, J = 7.3 Hz), 1.24 (3H, t, J = 7.3 Hz).       3-15   9.29 (1H, d, J = 1.8 Hz), 8.88 (1H, d, J = 1.4 Hz), 8.55 (1H, t, J = 1.8 Hz), 8.33 (1H, s), 7.57-7.50           (3H, m), 7.40 (1H, td, J1 = 7.6 Hz, J2 = 1.7 Hz), 2.85 (2H, q, J = 7.3 Hz), 1.25 (3H, t, J = 7.3 Hz).       3-29   8.64 (1H, d, J = 4.6 Hz), 8.57 (1H, s), 7.85 (1H, t, J = 8.0 Hz), 7.76 (1H, t, J = 7.6 Hz), 7.69 (1H, t,           J = 7.6 Hz), 7.56 (1H, d, J = 7.8 Hz), 7.31 (1H, dd, J1 = 7.6 Hz, J2 = 4.8 Hz), 3.39-3.30 (1H, m),           2.96-2.87 (1H, m), 1.37 (3H, t, J = 7.6 Hz).       3-30   9.29 (1H, d, J = 1.8 Hz), 8.92 (1H, d, J = 0.9 Hz), 8.54 (1H, s), 8.36 (1H, s), 8.27 (1H, dd, J1 = 8.0           Hz, J2 = 1.6 Hz), 7.80 (1H, td, J1 = 7.7 Hz, J2 = 1.2 Hz), 7.72 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz), 7.57           (1H, dd, J1 = 7.8 Hz, J2 = 0.9 Hz), 3.32 (1H, m), 2.93 (1H, m), 1.37 (3H, t, J = 7.6 Hz).       3-45   9.26 (1H, d, J = 1.8 Hz), 8.86 (1H, d, J = 1.4 Hz), 8.49 (1H, s), 8.43 (1H, s), 8.22 (1H, dd, J1 = 7.8           Hz, J2 = 1.8 Hz), 7.86 (1H, td, J1 = 7.6 Hz, J2 = 1.7 Hz), 7.81 (1H, td, J1 = 7.6 Hz, J2 = 1.4 Hz), 7.59           (1H, dd, J1 = 7.8 Hz, J2 = 1.4 Hz), 3.27 (2H, q, J = 7.5 Hz), 1.26 (3H, t, J = 7.3 Hz).       4-10   8.71 (1H, s), 8.32 (1H, s), 8.32 (1H, s), 7.83 (1H, d, J = 5.0 Hz), 7.56-7.49 (3H, m), 7.39 (1H, t,           J = 7.6 Hz), 2.83 (2H, q, J = 7.3 Hz), 1.24 (3H, t, J = 7.3 Hz).       4-25   8.74 (2H, d, J = 5.0 Hz), 8.31 (1H, s), 8.26 (1H, d, J = 8.2 Hz), 7.81-7.79 (3H, m), 7.71 (1H, t,           J = 7.6 Hz), 7.55 (1H, d, J = 8.2 Hz), 3.35-3.26 (1H, m), 2.96-2.87 (1H, m), 1.36 (3H, t, J = 7.3           Hz).                    
&lt;Formulation&gt;
 
     Specific examples of the method for formulating the compound of the present invention as an agricultural/horticultural insecticide or acaricide are described below in Formulation Examples 1 to 5. 
     Formulation Example 1: Dust 
     A dust containing 2 wt % of an active agent can be obtained by uniformly pulverizing and mixing a mixture of the compound (1-631) (2 parts by weight) of Synthesis Example 1, PAP (isopropylphosphoric acid ester) (1 part by weight) and clay (97 parts by weight). Furthermore, each dust can be obtained by the same method except for using the corresponding compound shown in Tables 1 to 4 in place of the compound of Synthesis Example 1. 
     Formulation Example 2: Wettable Powder 
     A wettable powder containing 20 wt % of an active agent can be obtained by uniformly pulverizing and mixing a mixture of the compound (1-631) (20 parts by weight) of Synthesis Example 1, sodium alkylbenzenesulfonate (3 parts by weight), polyoxyethylene alkylphenyl ether (5 parts by weight), and terra alba (72 parts by weight). Furthermore, each wettable powder can be obtained by the same method except for using the corresponding compound shown in Tables 1 to 4 in place of the compound of Synthesis Example 1. 
     Formulation Example 3: Emulsifiable Concentrate 
     An emulsifiable concentrate containing 30 wt % of an active agent can be obtained by mixing and dissolving the compound (1-631) (30 parts by weight) of Synthesis Example 1, methylnaphthalene (40 parts by weight), and polyoxyethylene alkylphenyl ether (30 parts by weight). Furthermore, each emulsifiable concentrate can be obtained by the same method except for using the corresponding compound shown in Tables 1 to 4 in place of the compound of Synthesis Example 1. 
     Formulation Example 4: Flowable Formulation 
     A flowable formulation containing 25 wt % of an active agent can be obtained by uniformly mixing a mixture of the compound (1-631) (25 parts by weight) of Synthesis Example 1, polyoxyethylene alkyl ether (1 part by weight), sodium alkylnaphthalenesulfonate (1 part by weight), xanthane gum (1 part by weight) and water (72 parts by weight). Furthermore, each flowable formulation can be obtained by the same method except for using the corresponding compound shown in Tables 1 to 4 in place of the compound of Synthesis Example 1. 
     Formulation Example 5: Granule 
     A granule containing 5 wt % of an active agent can be obtained by further adding water (15 parts by weight) to a mixture of the compound (1-631) (5 parts by weight) of Synthesis Example 1, sodium laurylsulfate (1 part by weight), calcium ligninsulfonate (5 parts by weight), bentonite (30 parts by weight) and clay (59 parts by weight), followed by kneading in a kneader, granulating in a granulator, and drying in a fluid drier. Furthermore, each granule can be obtained by the same method except for using the corresponding compound shown in Tables 1 to 4 in place of the compound (1-631) of Synthesis Example 1. 
     Specific examples of the evaluation for the control effect of the pest control agent according to the present invention obtained above are described below in Test Examples 1 to 5. 
     Test Example-1 : Spodoptera litura  Control Test 
     Cabbage seedlings grown in a cell tray were placed on a turntable, and 30 mL of a diluted emulsifiable concentrate (500 ppm) prepared according to Formulation Example 3 was uniformly sprayed thereon by means of a spray gun. After air drying, the seedlings were put in a plastic container having a cover perforated with air vents, and five  Spodoptera litura  at second instar larvae were released in each container, and the containers were placed in a constant temperature chamber at 25° C. (with lighting for 16 hours). Four days after the release, the number of surviving larvae was investigated, and the mortality rate (%) was calculated according to the following calculating formula (a). Test was conducted in duplicate.
 
Mortality rate (%)={1−(number of surviving larvae on investigation day in treatment plot/number of surviving larvae on investigation day in non-treatment plot)}×100  Formula (a):
 
     As representative examples, compounds of Compound Nos. 1-75, 1-81, 1-82, 1-83, 1-85, 1-86, 1-87, 1-88, 1-91, 1-197, 1-229, 1-236, 1-243, 1-251, 1-255, 1-278, 1-305, 1-310, 1-319, 1-336, 1-354, 1-360, 1-361, 1-363, 1-364, 1-365, 1-366, 1-367, 1-369, 1-370, 1-475, 1-507, 1-513, 1-520, 1-528, 1-536, 1-552, 1-554, 1-555, 1-562, 1-587, 1-596, 1-631, 1-637, 1-638, 1-639, 1-640, 1-641, 1-642, 1-643, 1-644, 1-646, 1-647, 1-752, 1-784, 1-786, 1-790, 1-791, 1-798, 1-802, 1-805, 1-806, 1-809, 1-810, 1-815, 1-820, 1-823, 1-830, 1-831, 1-832, 1-833, 1-860, 1-862, 1-867, 1-869, 2-30, 2-32, 2-33, 2-91, 2-96, 2-97, 2-99, 2-100, 2-102, 2-107, 2-112, 2-113, 2-127, 2-134, 2-135, 2-140, 2-143, 2-145, 2-147, 2-169, 2-171, 2-172, 2-230, 2-234, 2-235, 2-236, 2-238, 2-239, 2-241, 2-246, 2-252, 2-261, 2-262, 2-267, 2-275, 2-283, 2-285, 2-295, 2-297, 2-299, 2-309, 2-311, 2-312, 2-322, 2-323, 2-325, 2-329, 2-330, 2-332, 2-351, 2-353, 2-367, 2-370, 2-374, 2-375, 2-376, 2-377, 2-378, 2-379, 2-381, 2-386, 2-388, 2-389, 2-392, 2-393, 2-397, 2-398, 2-401, 2-402, 2-407, 2-408, 2-409, 2-410, 2-411, 2-414, 2-415, 2-420, 2-423, 2-425, 2-427, 3-14, 3-15, 3-29, 3-30, 3-45, 4-10, and 4-25 showed a mortality rate of 80% or more. 
     Test Example-2 : Nilaparvata lugens  Control Test 
     Sprouted rice seedlings grown in a plastic cup were placed on a turntable, and 30 mL of a diluted emulsifiable concentrate (500 ppm) prepared according to Formulation Example 3 was uniformly sprayed thereon by means of a spray gun. After air drying, the seedlings were put in a polycarbonate-made plastic container having a cover provided with nylon gauze, and ten  Nilaparvata lugens  at fourth instar larvae were released in each container, and the containers were placed in a constant temperature chamber at 25° C. (with lighting for 16 hours). Five days after the release, the number of surviving larvae was investigated, and the mortality rate (%) was calculated according to the following calculating formula (a). Test was conducted in duplicate.
 
Mortality rate (%)={1−(number of surviving larvae on investigation day in treatment plot/number of surviving larvae on investigation day in non-treatment plot)}×100  Formula (a):
 
     As representative examples, compounds of Compound Nos. 1-56, 1-83, 1-488, 1-578, 2-147, 2-409, 2-414, 2-427, 3-14, and 4-25 showed a mortality rate of 80% or more. 
     Test Example-3 : Aphis craccivora  Control Test 
     Three apterous adults of  Aphis craccivora  were released on each of broad bean (Vicia faba) seedlings grown in a plastic cup. One day after the release, the board bean seedlings were placed on a turntable, and 30 mL of a diluted emulsifiable concentrate (500 ppm) prepared according to Formulation Example 3 was uniformly sprayed thereon by means of a spray gun. After the treatment, the seedlings were placed in a constant temperature chamber at 25° C. (with lighting for 16 hours). Four days after the treatment, the number of parasitic adults and larvae was investigated, and the preventive value (%) was calculated according to the following calculating formula (b). Test was conducted in duplicate.
 
Preventive value (%)={1−(number of parasitic insects on investigation day in treatment plot/number of parasitic insects on investigation day in non-treatment plot)}×100  Formula (b):
 
     As representative examples, compounds of Compound Nos. 1-26, 1-232, 1-275, 1-510, 2-91, 2-100, 2-140, 2-230, 2-370, 2-375, 2-379, 2-407, 2-408, 2-420, 2-423, 3-15, and 3-45 showed a preventive value of 80% or more. 
     Test Example-4 : Tetranychus urticae  Control Test 
     Ten female adults of  Tetranychus urticae  were released on each of bean seedlings grown in a plastic cup. One day after the release, the bean seedlings were placed on a turntable, and 30 mL of a diluted emulsifiable concentrate (500 ppm) prepared according to Formulation Example 3 was uniformly sprayed thereon by means of a spray gun. After the treatment, the seedlings were placed in a constant temperature chamber at 25° C. (with lighting for 16 hours). Eight days after the treatment, the number of surviving parasitic insects was investigated, and the preventive value (%) was calculated according to the following calculating formula (b). Test was conducted in duplicate.
 
Preventive value (%)={1−(number of parasitic insects on investigation day in treatment plot/number of parasitic insects on investigation day in non-treatment plot)}×100  Formula (b):
 
     As representative examples, compound of Compound No. 1-834 showed a preventive value of 80% or more. 
     INDUSTRIAL APPLICABILITY 
     According to the present invention, a novel 1,2,3-triazole derivative offering an excellent insecticidal or acaricidal effect and an insecticide or acaricide containing the 1,2,3-triazole derivative can be provided. 
     While the invention has been described in detail and with reference to specific embodiments thereof, it will be apparent to one skilled in the art that various changes and modifications can be made therein without departing from the spirit and scope of the invention. 
     This application is based on Japanese Patent Application (Patent Application No. 2015-233791) filed on Nov. 30, 2015, the contents of which are incorporated herein by way of reference.