Patent Publication Number: US-2009226420-A1

Title: Methods of Determining the Risk of Developing Coronary Artery Disease

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     This application claims the benefit of the filing date of U.S. Application No. 60/735,694, filed Nov. 10, 2005, entitled “METHODS OF DETERMINING THE RISK OF DEVELOPING CORONARY ARTERY DISEASE.” The entire teachings of the referenced application are herein incorporated by reference. 
    
    
     STATEMENT REGARDING FEDERALLY-SPONSORED RESEARCH OR DEVELOPMENT 
     The invention described herein was supported, in whole or in part, by the National Institute of Health Grant Nos. P01-HL73042 and R01-HL073389. The United States government has certain rights in the invention. 
    
    
     FIELD OF THE INVENTION 
     The present invention is in the field of vascular disease diagnosis and therapy. In particular, the present invention relates to specific single nucleotide polymorphisms (SNPs) in the human genome, and their association with vascular disease and related pathologies, in particular, coronary artery disease (CAD) such as coronary stenosis. 
     BACKGROUND OF THE INVENTION 
     Cardiovascular disorders are a cause of significant morbidity and mortality in the United States. Among the more common cardiovascular disorders are coronary artery diseases (CADs). CADs, sometimes designated coronary heart diseases or ischemic heart diseases, are characterized by insufficiency in blood supply to cardiac muscle. CADs can be manifested as acute cardiac ischemia (e.g., angina pectoris or myocardial infarction) or chronic cardiac ischemia (e.g., coronary arteriosclerosis or coronary atherosclerosis). CADs are a common cause of cardiac failure, cardiac arrhythmias, and sudden death. In patients afflicted with CADs, the cardiac muscle is not sufficiently supplied with oxygen. Severe cardiac ischemia can be manifested as severe pain or cardiac damage. Less severe ischemia can damage cardiac muscle and cause changes to cardiac tissues over the long term that impair cardiac function. 
     Many disorders, including CADs, develop over time and could be delayed, inhibited, lessened in severity, or prevented altogether by making lifestyle changes or through pharmaceutical treatment. For cardiovascular disorders such as CAD, such changes include increasing exercise, adjusting diet, consuming nutritional or pharmaceutical products known to be effective against cardiovascular disorders, and undergoing heightened medical monitoring. These changes are often not made, due to the expense or inconvenience of the changes to an individual and on her subjective belief that she is not at high risk for cardiovascular disorders. Improved monitoring of cardiovascular health can help to identify individuals at risk for developing cardiovascular disorders, including CAD, and permit for more informed decisions as to whether lifestyle changes are justified. 
     One way to identify subjects at high risk for developing CAD is by identifying genetic elements that predispose an individual to develop CAD. Polymorphisms conferring higher risks to non-cardiovascular diseases have been identified which aid in their diagnosis. Apolipoprotein E genetic screening aids in identifying genetic carriers of the apoE4 polymorphism in dementia patients for the differential diagnosis of Alzheimer&#39;s disease. Factor V Leiden polymorphisms signals a predisposition to deep venous thrombosis. The identification of polymorphisms in disease-associated genes also aids in designing an effective treatment plan for the disorder. For example, in the treatment of cancer, diagnosis of genetic variants in tumor cells is used for the selection of the most appropriate treatment regimen for the individual patient. In breast cancer, genetic variation in estrogen receptor expression or heregulin type 2 (Her2) receptor tyrosine kinase expression determine if anti-estrogenic drugs (e.g. tamoxifen) or anti-Her2 antibody (e.g. Herceptin) will be incorporated into the treatment plan. In chronic myeloid leukemia (CML) diagnosis of the Philadelphia chromosome genetic translocation fusing the genes encoding the Bcr and Abl receptor tyrosine kinases indicates that Gleevec (ST1571), a specific inhibitor of the Bcr-Abl kinase should be used for treatment of the cancer. For CML patients with such a genetic alteration, inhibition of the Bcr-Abl kinase leads to rapid elimination of the tumor cells and remission from leukemia. 
     Therefore, a need remains for the identification of genomic polymorphisms that predispose an individual to develop cardiovascular diseases such as CAD and that aid in their treatment. The invention provides such CAD-determinative genes and polymorphisms, and related assays, satisfying this need. 
     SUMMARY OF THE INVENTION 
     The invention broadly relates to estimating, and aiding to estimate, the likelihood that a subject will be afflicted with cardiovascular disease, and to identifying subjects with an elevated risk of developing cardiovascular disease and to related kits and reagents. In one embodiment, the cardiovascular disease is coronary artery disease (CAD). The invention also relates, in part, to methods and reagents for identifying, or aiding in the identification of, subjects at high risk of developing CAD or other cardiovascular diseases. 
     Another aspect of the invention provides a method for identifying an individual who has an altered risk for developing CAD, comprising detecting the presence of a single nucleotide polymorphism (SNP) in said individual&#39;s nucleic acids, wherein the presence of the SNP is correlated with an altered risk for coronary stenosis in said individual. In one embodiment, the SNP is selected from SNPs set forth in Tables 1-5. In one embodiment, the SNP is represented by a SEQ ID NOs: selected from 1-575. In one embodiment, the altered risk is an increased risk. In one embodiment, the detection is carried out by a process selected from the group consisting of: allele-specific probe hybridization, allele-specific primer extension, allele-specific amplification, sequencing, 5′ nuclease digestion, molecular beacon assay, oligonucleotide ligation assay, size analysis, and single-stranded conformation polymorphism. 
     Assessments of genomic polymorphism content in two or more of the CAD-determinative genes can be combined to determine the risk of a subject in developing cardiovascular disease. This assessment of cardiovascular health can be used to predict the likelihood that the human will develop CAD or other cardiovascular disorders such as myocardial infarction and hypertension. Identification of high-risk subjects allows for the early intervention to prevent, delay, or ameliorate the onset of cardiovascular disease. 
     Another aspect of the invention provides an isolated nucleic acid molecule comprising at least 10, 15, 20, 21 or more contiguous nucleotides, wherein one of the nucleotides is a single nucleotide polymorphism (SNP) selected from any one of the nucleotide sequences in SEQ ID NOS: 1-575, or a complement thereof. 
     One aspect of the present invention relates to an isolated nucleic acid molecule comprising a nucleotide sequence in which at least one nucleotide is a SNP disclosed in Tables 1-4. In an alternative embodiment, a nucleic acid of the invention is an amplified polynucleotide, which is produced by amplification of a SNP-containing nucleic acid template. In another embodiment, the invention provides for a variant protein which is encoded by a nucleic acid molecule containing a SNP disclosed herein. In yet another embodiment of the invention, a reagent for detecting a SNP in the context of its naturally-occurring flanking nucleotide sequences (which can be, e.g., either DNA or mRNA) is provided. In particular, such a reagent may be in the form of, for example, a hybridization probe or an amplification primer that is useful in the specific detection of a SNP of interest. In an alternative embodiment, a protein detection reagent is used to detect a variant protein which is encoded by a nucleic acid molecule containing a SNP disclosed herein. A preferred embodiment of a protein detection reagent is an antibody or an antigen-reactive antibody fragment. 
     Another aspect of the invention provides kits comprising SNP detection reagents, and methods for detecting the SNPs disclosed herein by employing detection reagents. In a specific embodiment, the present invention provides for a method of identifying an individual having an increased or decreased risk of developing coronary artery disease by detecting the presence or absence of one or more SNP alleles disclosed herein. In another embodiment, a method for diagnosis of coronary artery disease by detecting the presence or absence of one or more SNP alleles disclosed herein is provided. 
     The nucleic acid molecules of the invention can be inserted in an expression vector, such as to produce a variant protein in a host cell. Thus, the present invention also provides for a vector comprising a SNP-containing nucleic acid molecule, genetically-engineered host cells containing the vector, and methods for expressing a recombinant variant protein using such host cells. In another specific embodiment, the host cells, SNP-containing nucleic acid molecules, and/or variant proteins can be used as targets in a method for screening and identifying therapeutic agents or pharmaceutical compounds useful in the treatment of coronary artery disease. 
     Another aspect of the invention provides a method for treating coronary artery disease in a human subject wherein said human subject harbors a SNP, gene, transcript, and/or encoded protein identified in Tables 1-4, which method comprises administering to said human subject a therapeutically or prophylactically effective amount of one or more agents counteracting the effects of the disease, such as by inhibiting (or stimulating) the activity of the gene, transcript, and/or encoded protein identified in Tables 1-4. 
     Another aspect of this invention provides a method for treating coronary artery disease in a human subject, which method comprises: (i) determining that said human subject harbors a SNP, gene, transcript, and/or encoded protein identified in Tables 1-4, and (ii) administering to said subject a therapeutically or prophylactically effective amount of one or more agents counteracting the effects of the disease. 
     Another aspect of this invention provides a method for identifying an agent useful in therapeutically or prophylactically treating coronary artery disease in a human subject wherein said human subject harbors a SNP, gene, transcript, and/or encoded protein identified in Tables 1-2, which method comprises contacting the gene, transcript, or encoded protein with a candidate agent under conditions suitable to allow formation of a binding complex between the gene, transcript, or encoded protein and the candidate agent and detecting the formation of the binding complex, wherein the presence of the complex identifies said agent. 
     Another aspect of the invention provides a method for stratifying a patient population for treatment of coronary artery disease, wherein said population has an altered risk for developing coronary artery disease due to the presence of a single nucleotide polymorphism (SNP) in any one of the nucleotide sequences of SEQ ID NOS: 1-575 in an individual&#39;s nucleic acids from said population, comprising detecting the SNP, wherein the presence of the SNP is correlated with an altered risk for coronary artery disease in said individual thereby indicating said individual should receive treatment for coronary artery disease. 
     The methods of SNP genotyping provided by the invention are useful for numerous practical applications. Examples of such applications include, but are not limited to, disease predisposition screening, disease diagnosis, disease prognosis, disease progression monitoring, determining therapeutic strategies based on an individual&#39;s genotype (“pharmacogenomics”), developing therapeutic agents based on SNP genotypes associated with a disease or likelihood of responding to a drug, stratifying a patient population for clinical trial for a treatment regimen, predicting the likelihood that an individual will experience toxic side effects from a therapeutic agent, and human identification applications such as forensics. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  shows SNP selection algorithm for candidate genes from the association with human-disease components of the AGENDA study. 
         FIG. 2  shows a graphical representation of the largest negative Log (base 10) p-values for 1065 SNPs in 275 genes. This figure is in color. 
     
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     I. Overview 
     The invention provides, in part, novel methods of determining the risk that an individual will develop a cardiovascular disease. The invention also provides methods of identifying subjects having an elevated risk of developing a cardiovascular disease, such as CAD. The invention is based, in part, on the unexpected findings by applicants that polymorphisms in several genes are highly correlated with the susceptibility of the subject to develop CAD. 
     The methods and compositions described herein can be used in determining the susceptibility to prognosis of various forms of coronary artery disease. Moreover, the methods and compositions of the present invention can also be used to facilitate the prevention of cardiovascular disease in an individuals found to be at an elevated risk for developing the disease. 
     One aspect of the invention relates to specific single nucleotide polymorphisms (SNPs) in the human genome, and their association with vascular disease and related pathologies, in particular, coronary artery disease (CAD) such as coronary stenosis. Based on differences in allele frequencies in the vascular disease patient population relative to normal individuals, the naturally-occurring SNPs disclosed herein can be used as targets for the design of diagnostic reagents and the development of therapeutic agents, as well as for disease association and linkage analysis. In particular, the SNPs of the present invention are useful for identifying an individual who is at an increased or decreased risk of developing vascular disease and for early detection of the disease, for providing clinically important information for the prevention and/or treatment of vascular disease, and for screening and selecting therapeutic agents. The SNPs disclosed herein are also useful for human identification applications. Methods, assays, kits, and reagents for detecting the presence of these polymorphisms and their encoded products are provided. 
     The present invention provides novel SNPs associated with coronary artery disease, as well as some SNPs that were previously known in the art, but were not previously known to be associated with coronary stenosis. Accordingly, the present invention provides novel compositions and methods based on the novel SNPs disclosed herein, and also provides novel methods of using the known, but previously unassociated, SNPs in methods relating to coronary stenosis (e.g., for diagnosing coronary stenosis, etc.). 
     One specific aspect of the invention provides methods of predicting the risk of developing CAD. One aspect of the invention provides a method of diagnosing premature CAD in an individual, including previously undiagnosed individuals or individuals without any type of cardiovascular disease. In one embodiment, the method comprises obtaining a DNA sample from the individual and determining the presence of one or more polymorphisms in at least one CAD-determinative gene. The presence of one or more polymorphisms is an indication that the individual is at high risk of developing a cardiovascular disease, such as CAD. Preferred polymorphisms are listed on Tables 1, 2 and 3. In one embodiment, the polymorphism is a polymorphism from Table 1 showing a p value of less than 0.05, 0.04, 0.03. 0.02. 0.01, 0.05, 0.02, 0.01, 0.005, 0.002 or 0.001. In some embodiments, the polymorphic change is at the same location along the genome as the polymorphisms found in Tables 1, 2 or 3. As an illustrative embodiment, if a given polymorphism in Table 1 consisted of a G to A nucleotide change at a given position on the genome, some embodiments would include screening for the change of G to C or G to T. Accordingly, in some embodiments, the presence of a polymorphism at the genomic position, regardless of the nature of the nucleotide change(s), indicates that the subject is at a higher risk of developing a cardiovascular disease. In one embodiment, the absence of the wild-type sequence in a polymorphic region is indicative of a higher likelihood of developing CAD. 
     The methods of the present invention may be used with a variety of contexts and maybe be used to assess the status of a variety of individuals. For example, the methods may be used to assess the status of individuals with no previous diagnosis of coronary artery disease, or with no significant cardiovascular risk factors. Cardiovascular risk factors include, but are not limited to, cholesterol, HDL cholesterol, systolic blood pressure, cigarette smoking, exercise, alcohol, race, obesity, family history of premature coronary artery disease, and medication use, including aspirin, statins, B-blockers and hormone replacement therapy in women. 
     Other indicia predictive of CAD can be detected or monitored in the subject in conjunction with the detection of polymorphisms in CAD-determinative genes. This may be useful to increase the predictive power of the methods described herein. Preferred indicia include the detection of additional CAD-determinative polymorphisms in genes not listed in Tables 1, 2 or 3, medical examination of the subject&#39;s cardiovascular system, and detection of gene products or other metabolites in a sample from a patient, such as a blood sample. In some embodiments, additional factors that may be monitored may be administration of pharmaceuticals known or suspected of having cardiovascular effects, such as increasing blood pressure, preferably in at least 5% or 10% of subjects who are administered the pharmaceuticals. In addition, the presence of cardiovascular risk factors, such as those listed in the preceding paragraph, may be also be weighed when assessing the risk of a subject for developing the cardiovascular disease. 
     II. Definitions 
     A “coronary artery disease” (“CAD”) is a pathological state characterized by insufficiency of oxygen delivery to cardiac muscle, wherein the condition is associated with some dysfunction of coronary blood vessels. As used in this disclosure, CADs include both disorders in which symptomatic and/or asymptomatic cardiac ischemia occurs (e.g., angina pectoris and myocardial infarction) and disorders that gradually lead to chronic or acute cardiac ischemia, even at the stage of the disorder at which such ischemia is not yet evident (e.g., coronary arteriosclerosis and atherosclerosis). 
     An “increased risk” refers to a statistically higher frequency of occurrence of the disease or condition in an individual carrying a particular polymorphic allele in comparison to the frequency of occurrence of the disease or condition in a member of a population that does not carry the particular polymorphic allele. 
     A “treatment plan” refers to at least one intervention undertaken to modify the effect of a risk factor upon a patient. A treatment plan for a cardiovascular disorder or disease can address those risk factors that pertain to cardiovascular disorders or diseases. A treatment plan can include an intervention that focuses on changing patient behavior, such as stopping smoking. A treatment plan can include an intervention whereby a therapeutic agent is administered to a patient. As examples, cholesterol levels can be lowered with proper medication, and diabetes can be controlled with insulin. Nicotine addiction can be treated by withdrawal medications. A treatment plan can include an intervention that is diagnostic. The presence of the risk factor of hypertension, for example, can give rise to a diagnostic intervention whereby the etiology of the hypertension is determined. After the reason for the hypertension is identified, further treatments may be administered. 
     The phrase “predicting the likelihood of developing” as used herein refers to methods by which the skilled artisan can predict onset of a cardiovascular condition in an individual. The term “predicting” does not refer to the ability to predict the outcome with 100% accuracy. Instead, the skilled artisan will understand that the term “predicting” refers to forecast of an increased or a decreased probability that a certain outcome will occur; that is, that an outcome is more likely to occur in an individual having one or more CAD-determinative polymorphisms. 
     A subject at higher risk of developing a cardiovascular disease refers to a subject having at least a 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%, 125%, 150%, 200%, 300%, 400%, 500%, 600%, 7000/, 800%, 900% or 1000% greater probability of developing the condition, relative to the general population. In one embodiment, the comparison is not to a general population but rather to a population matched by one or more factors such as age, sex, race, ethnicity, etc. In one embodiment, the population is one existing within a time frame of 5, 6, 7, 8, 9, 10, 15, 20, 25, 30, 35, 40, 45 or 50 years from the time of testing. 
     The term “polymorphism”, as used herein, refers to a difference in the nucleotide sequence of a given region, such as a region in a chromosome, as compared to a nucleotide sequence in a homologous region of another individual, in particular, a difference in the nucleotide of a given region which differs between individuals of the same species. A polymorphism is generally defined in relation to a reference sequence, usually referred to as the “wild-type” sequence. Polymorphisms include single nucleotide differences, differences in sequence of more than one nucleotide, and single or multiple nucleotide insertions, inversions and deletions. In certain embodiments, the polymorphism is within a non-coding region or in a translated region. In certain embodiments, the polymorphism is a silent polymorphism within a translated region. In some embodiments, the polymorphism results in an amino acid substitution. Where a polymorphic site is a single nucleotide in length, the site is referred to as a single nucleotide polymorphism (“SNP”). For example, if at a particular chromosomal location, one member of a population has an adenine and another member of the population has a thymine at the same position, then this position is a polymorphic site, and, more specifically, the polymorphic site is a SNP. Each version of the sequence with respect to the polymorphic site is referred to herein as an “allele” of the polymorphic site. Thus, in the previous example, the SNP allows for both an adenine allele and a thymine allele. 
     A “haplotype,” as described herein, refers to a combination of genetic markers (“alleles”), such as the SNPs set forth in Tables 1 and 2 and 3. 
     The nucleotide designation “R” refers to A or G nucleotides, while designation ‘N’ refers to G or A or T or C nucleotides, in accordance with IUPAC designations. 
     III. CAD-Determinative Alleles and Polymorohisms 
     The present invention is based, at least in part, on the identification of alleles, in multiple genes, that are associated (to a statistically-significant extent) with the development of CAD in humans. Detection of these alleles in a subject indicates that the subject is predisposed to the development of a cardiovascular disease and in particular CAD. The identification of individuals predisposed to developing CAD, as identified using the methods described here, may prove useful in allowing the implementation of preventive treatment plans to delay or reduce the incidence of CAD. 
     Those skilled in the art will readily recognize that nucleic acid molecules may be double-stranded molecules and that reference to a particular site on one strand refers, as well, to the corresponding site on a complementary strand. In defining a SNP position, SNP allele, or nucleotide sequence, reference to an adenine, a thymine (uridine), a cytosine, or a guanine at a particular site on one strand of a nucleic acid molecule also defines the thymine (uridine), adenine, guanine, or cytosine (respectively) at the corresponding site on a complementary strand of the nucleic acid molecule. Thus, reference may be made to either strand in order to refer to a particular SNP position, SNP allele, or nucleotide sequence. Probes and primers, may be designed to hybridize to either strand and SNP genotyping methods disclosed herein may generally target either strand. Throughout the specification, in identifying a SNP position, reference is generally made to the protein-encoding strand, only for the purpose of convenience One aspect of the invention provides a method of estimating, or aiding in the estimation of, the risk of developing a cardiovascular disease, such as CAD, in a subject, the method comprising (i) providing a nucleic acid sample from the subject; (ii) detecting the presence of one or more single nucleotide polymorphisms (SNPs) in a CAD-determinative gene in the nucleic acid sample, wherein the presence of one or more SNPs reflects a higher risk of developing the cardiovascular disease. A related aspect of the invention provides a method of identifying a subject having an elevated risk of developing a cardiovascular disease, such as CAD, the method comprising (i) providing a nucleic acid sample from the subject; (ii) detecting the presence of one or more single nucleotide polymorphisms (SNPs) in a CAD-determinative gene in the genomic sample, wherein a subject having one or more SNPs is identified as a subject having an elevated risk of developing cardiovascular disease. To better characterize the subject&#39;s genetic content, occurrence of polymorphisms that are not associated with a disorder can also be assessed, so that one can determine whether the human is 1) homozygous for the CAD-determinative polymorphism at a genomic site, 2) heterozygous for a CAD-determinative and disorder-non-associated polymorphisms at the genomic site, or 3) homozygous for a CAD-non-associated polymorphisms at the site. In one embodiment, both the presence of a SNP polymorphism and of the wild-type sequence is determined. 
     Tables 1-5 provide a variety of information about SNPs of the present invention that are associated with coronary artery disease. Tables 4 (SEQ ID NOs:1-575) and Table 5 (SEQ ID NOs: 576-1050) disclose genomic SNP sequences. The sequences on Table 4 correspond to genomic sequences containing the SNP, while those on Table 5 have the corresponding genomic sequences without the SNP. Table 3 provides additional information for these sequences, including the chromosome position of the SNP, the gene locus in which the SNP is found, the Genbank accession number (which provides another way of naming the gene locus), a probe number and a genomic location within the chromosomes. Table 3 also provides the SEQ ID NOs for the SNP sequence and the nonSNP sequence for cross-reference with Tables 4-5. 
     In one embodiment, the CAD-determinative gene containing the SNP is one of the genes listed in Table 1. Table 1 includes the following genes: A1M1L, PLA2G7, OR7E29P, PLN, PTPN6, C1ORF38, GATA2, IL7R, MYLK, ANPEP, PIK3R4, RPLP2, OLR1, PNPLA2, TCF4, ACP5, SELP, BAX, CPNE4, TAL1, KLF15, ABCB1, LHFPL2, ITGAX, LOC389142, PLXNC1, SLA, ELL, NPY, IGSF11, ITPK1, ASB1, SELB, LOC131873, PCCA, HAPIP, PLAUR, SIDT1, RPN1, BPAG1, ROR2, MMP12, GAP43, FSTL1, MAP4, ZNF217, ALOX5, NPHP3, GPNMB, SPP1, ZNF80, MGP, C3ORF15, NEK11, POLQ, ADFP, UBXD1, 38413, FLJ46299, ZBTB20, HLA-DQA2, ZXDC, GRN, PSCD1, GYS1, C14ORF132, CD80, CDGAP, LMOD1, SLC41A3, HOXD1, STAT5A, OPRM1, ITPR2, HIF1A, PKD2, STEAP, AGTR1, NDUFB4, GLRA3, MEF2A, STXBP5L, APOBEC3D, FMNL1, PLXND1, ATP2C1, RUVBL1, CASR, PTPRR, SMPDL3A, APOD, APG3L, FLJ35880, TMCC1, CD96, C1QB, CTSD, FLI1, MMP9, TCIRG1, ITGB5, FLJ25414, NR1H3, HSPBAP1, APOC1, THPO, FTL, HADHSC, ALOX5AP, LAIR1, UPP1, LAPTM5, CSTA, ADCY5, PHLDB2, GM2A, NUDT16, ACSL1, VAMP5, ACP2, HLA-DPA1, TUBA3, MMP7, H41, NR112, FGFR2, OBA, CHAF1A, GSK3B, DOCK2, URB, HCLS1, CD200R1, SLCO2B1, B4GALT4, PLCXD2, FABP7, CAMKK2, FCGR1A, SELL, SELE, HNRPM, MGC45840, F5, SMTN, RAI3, HLA-DRA, CSTB, FLJ12592 and TAGLN3. 
     In one embodiment, the SNP is one of those listed in Tables 1-4. In another embodiment, the SNP is one that is highly-statistically associated (p&lt;0.1, p&lt;0.05 or p&lt;0.01) with the development of CAD. In another embodiment, the SNP is a SNP in linkage disequilibrium with one of the aforementioned SNPs. The third and fourth columns in Table 1 indicate the chromosome and the location within chromosome where the polymorphism in located. 
     In one embodiment, the method of estimating the risk of developing coronary artery disease (CAD) in a subject comprises determining the presence of more than one SNP from Tables 1-4 in the genomic sample from the subject, which may be from one gene of from two or more genes. 
     In addition to the SNPs described in Tables 1-4, one of skill in the art can readily identify other alleles (including polymorphisms and mutations) that are in linkage disequilibrium with one of the SNPs described herein. For example, a nucleic acid sample from a first group of subjects without CAD can be collected, as well as DNA from a second group of subjects with CAD. The nucleic acid sample can then be compared to identify those alleles that are over-represented in the second group as compared with the first group, wherein such alleles are presumably associated with CAD. Alternatively, alleles that are in linkage disequilibrium with a CAD associated-allele can be identified, for example, by genotyping a large population and performing statistical analysis to determine which alleles appear more commonly together than expected. 
     Preferably the group is chosen to be comprised of genetically-related individuals. Genetically-related individuals include individuals from the same race, the same ethnic group, or even the same family. As the degree of genetic relatedness between a control group and a test group increases, so does the predictive value of polymorphic alleles which are ever more distantly linked to a disease-causing allele. This is because less evolutionary time has passed to allow polymorphisms which are linked along a chromosome in a founder population to redistribute through genetic cross-over events. Thus race-specific, ethnic-specific, and even family-specific diagnostic genotyping assays can be developed to allow for the detection of disease alleles which arose at ever more recent times in human evolution, e.g., after divergence of the major human races, after the separation of human populations into distinct ethnic groups, and even within the recent history of a particular family line. 
     Appropriate probes may be designed to hybridize to one of the alleles listed in Tables 1-3. Alternatively, these probes may incorporate other regions of the relevant genomic locus, including intergenic sequences. Yet other polymorphisms available for use with the immediate invention are obtainable from various public sources. For example, the human genome database collects intragenic SNPs, is searchable by sequence (http://hgbase.interactiva.de). Also available is a human polymorphism database maintained by NCBI (http://www.ncbi.nim.nih.gov/projects/SNP/). From such sources SNPs as well as other human polymorphisms may be found. 
     IV. Detection of CAD-Determinative Polymorphisms 
     Many methods are available for detecting specific alleles at human polymorphic loci. The preferred method for detecting a specific polymorphic allele will depend, in part, upon the molecular nature of the polymorphism. SNPs are most frequently biallelic-occurring in only two different forms (although up to four different forms of an SNP, corresponding to the four different nucleotide bases occurring in DNA, are theoretically possible). Because SNPs typically have only two alleles, they can be genotyped by a simple plus/minus assay rather than a length measurement, making them more amenable to automation. 
     A variety of methods are available for detecting the presence of a particular single nucleotide polymorphic allele in an individual. Advancements in this field have provided accurate, easy, and inexpensive large-scale SNP genotyping. Most recently, for example, several new techniques have been described including dynamic allele-specific hybridization (DASH), microplate array diagonal gel electrophoresis (MADGE), pyrosequencing, oligonucleotide-specific ligation, the TaqMan system as well as various DNA “chip” technologies such as the Affymetrix SNP chips. These methods require amplification of the target genetic region, typically by PCR. Still other newly developed methods, based on the generation of small signal molecules by invasive cleavage followed by mass spectrometry or immobilized padlock probes and rolling-circle amplification, might eventually eliminate the need for PCR. Several of the methods known in the art for detecting specific single nucleotide polymorphisms are summarized below. The method of the present invention is understood to include all available methods. 
     Any cell type or tissue may be utilized to obtain nucleic acid samples for use in the diagnostics described herein. In a preferred embodiment, the DNA sample is obtained from a bodily fluid, e.g., blood, obtained by known techniques (e.g. venipuncture), or saliva. Alternatively, nucleic acid tests can be performed on dry samples (e.g. hair or skin). When using RNA or protein, the cells or tissues that may be utilized must express a CAD-determinative gene. In one embodiment, biological samples such as blood, bone, hair, saliva, or semen may be used. 
     Exonuclease-Resistant Nucleotide 
     In one embodiment, the single base polymorphism can be detected by using a specialized exonuclease-resistant nucleotide, as disclosed, e.g., in Mundy, C. R. (U.S. Pat. No. 4,656,127). According to the method, a primer complementary to the allelic sequence immediately 3′ to the polymorphic site is permitted to hybridize to a target molecule obtained from a particular animal or human. If the polymorphic site on the target molecule contains a nucleotide that is complementary to the particular exonuclease-resistant nucleotide derivative present, then that derivative will be incorporated onto the end of the hybridized primer. Such incorporation renders the primer resistant to exonuclease, and thereby permits its detection. Since the identity of the exonuclease-resistant derivative of the sample is known, a finding that the primer has become resistant to exonucleases reveals that the nucleotide present in the polymorphic site of the target molecule was complementary to that of the nucleotide derivative used in the reaction. This method has the advantage that it does not require the determination of large amounts of extraneous sequence data. 
     Solution-Based Method 
     In another embodiment of the invention, a solution-based method is used for determining the identity of the nucleotide of a polymorphic site. Cohen, D. et al. (French Patent 2,650,840; PCT Appln. No. WO91/02087). As in the Mundy method of U.S. Pat. No. 4,656,127, a primer is employed that is complementary to allelic sequences immediately 3′ to a polymorphic site. The method determines the identity of the nucleotide of that site using labeled dideoxynucleotide derivatives, which, if complementary to the nucleotide of the polymorphic site will become incorporated onto the terminus of the primer. 
     Genetic Bit Analysis 
     An alternative method, known as Genetic Bit Analysis or GBA™ is described by Goelet, P. et al. (PCT Appln. No. 92/15712). The method of Goelet, P. et al. uses mixtures of labeled terminators and a primer that is complementary to the sequence 3′ to a polymorphic site. The labeled terminator that is incorporated is thus determined by, and complementary to, the nucleotide present in the polymorphic site of the target molecule being evaluated. In contrast to the method of Cohen et al. (French Patent 2,650,840; PCT Appln. No. WO91/02087) the method of Goelet, P. et al. is preferably a heterogeneous phase assay, in which the primer or the target molecule is immobilized to a solid phase. 
     Primer-Guided Nucleotide Incorporation 
     Recently, several primer-guided nucleotide incorporation procedures for assaying polymorphic sites in DNA have been described (Komher, J. S. et al., Nucl. Acids. Res. 17:7779-7784 (1989); Sokolov, B. P., Nucl. Acids Res. 18:3671 (1990); Syvanen, A.-C., et al., Genomics 8:684-692 (1990); Kuppuswamy, M. N. et al., Proc. Natl. Acad. Sci. (U.S.A.) 88:1143-1147 (1991); Prezant, T. R. et al., Hum. Mutat. 1:159-164 (1992); Ugozzoli, L. et al., GATA 9:107-112 (1992); Nyren, P. et al., Anal. Biochem. 208:171-175 (1993)). These methods differ from GBA™ in that they all rely on the incorporation of labeled deoxynucleotides to discriminate between bases at a polymorphic site. In such a format, since the signal is proportional to the number of deoxynucleotides incorporated, polymorphisms that occur in runs of the same nucleotide can result in signals that are proportional to the length of the run (Syvanen, A.-C., et al., Amer. J. Hum. Genet. 52:46-59 (1993)). 
     Protein Truncation Test (PTT) 
     For SNPs that produce premature termination of protein translation, the protein truncation test (PTT) offers an efficient diagnostic approach (Roest, et. al., (1993) Hum. Mol. Genet. 2:1719-21; van der Luijt, et. al., (1994) Genomics 20:14). For PTT, RNA is initially isolated from available tissue and reverse-transcribed, and the segment of interest is amplified by PCR. The products of reverse transcription PCR are then used as a template for nested PCR amplification with a primer that contains an RNA polymerase promoter and a sequence for initiating eukaryotic translation. After amplification of the region of interest, the unique motifs incorporated into the primer permit sequential in vitro transcription and translation of the PCR products. Upon sodium dodecyl sulfate-polyacrylamide gel electrophoresis of translation products, the appearance of truncated polypeptides signals the presence of a mutation that causes premature termination of translation. In a variation of this technique, DNA (as opposed to RNA) is used as a PCR template when the target region of interest is derived from a single exon. 
     In Situ Tissue Sections 
     Diagnostic procedures may also be performed in situ directly upon tissue sections (fixed and/or frozen) of subject tissue obtained from biopsies or resections, such that no nucleic acid purification is necessary. Nucleic acid reagents may be used as probes and/or primers for such in situ procedures (see, for example, Nuovo, G. J., 1992, PCR in situ hybridization: protocols and applications, Raven Press, N.Y.). 
     Allele-Specific Hybridization 
     In one preferred detection method is allele specific hybridization using probes overlapping a region of at least one allele of a CAD-determinative gene having about 5, 10, 20, 25, or 30 nucleotides around the mutation or polymorphic region. In one embodiment of the invention, several probes capable of hybridizing specifically to other allelic variants involved in CAD are attached to a solid phase support, e.g., a “chip” (which can hold up to about 250,000 oligonucleotides). Oligonucleotides can be bound to a solid support by a variety of processes, including lithography. Mutation detection analysis using these chips comprising oligonucleotides, also termed “DNA probe arrays” is described e.g., in Cronin et al. (1996) Human Mutation 7:244. In one embodiment, a chip comprises all the allelic variants of at least one polymorphic region of a CAD-determinative gene. The solid phase support is then contacted with a test nucleic acid and hybridization to the specific probes is detected. Accordingly, the identity of numerous allelic variants of one or more genes can be identified in a simple hybridization experiment. The design and use of allele-specific probes for analyzing polymorphisms is known in the art (see, e.g., Dattagupta, EP 235,726, Saiki, WO 89/11548). WO 95/11995 describes subarrays that are optimized for detection of variant forms of a pre-characterized polymorphism. 
     DNA-Amplification and PCR-Based Methods 
     These techniques may also comprise the step of amplifying the nucleic acid before analysis. Amplification techniques are known to those of skill in the art and include, but are not limited to cloning, polymerase chain reaction (PCR), polymerase chain reaction of specific alleles (ASA), ligase chain reaction (LCR), nested polymerase chain reaction, self-sustained sequence replication (Guatelli, J. C. et al., 1990, Proc. Natl. Acad. Sci. USA 87:1874-1878), transcriptional amplification system (Kwoh, D. Y. et al., 1989, Proc. Natl. Acad. Sci. USA 86:1173-1177), and Q-Beta Replicase (Lizardi, P. M. et al., 1988, Bio/Technology 6:1197). PCR-based detection means can include multiplex amplification of a plurality of markers simultaneously. For example, it is well known in the art to select PCR primers to generate PCR products that do not overlap in size and can be analyzed simultaneously. Alternatively, it is possible to amplify different markers with primers that are differentially labeled and thus can each be differentially detected. Of course, hybridization based detection means allow the differential detection of multiple PCR products in a sample. Other techniques are known in the art to allow multiplex analyses of a plurality of markers. Amplification products may be assayed in a variety of ways, including size analysis, restriction digestion followed by size analysis, detecting specific tagged oligonucleotide primers in the reaction products, allele-specific oligonucleotide (ASO) hybridization, allele specific 5′ exonuclease detection, sequencing, hybridization, and the like. 
     A merely illustrative embodiment of a method using PCR-amplification includes the steps of (i) collecting a sample of cells from a subject, (ii) isolating nucleic acid (e.g., genomic, mRNA or both) from the cells of the sample, (iii) contacting the nucleic acid sample with one or more primers which specifically hybridize 5′ and 3′ to at least one CAD-determinative gene under conditions such that hybridization and amplification of the allele occurs, and (iv) detecting the amplification product. These detection schemes are especially useful for the detection of nucleic acid molecules if such molecules are present in very low numbers. 
     In a preferred embodiment of the subject assay, the allele of an CAD-determinative gene is identified by alterations in restriction enzyme cleavage patterns. For example, sample and control DNA is isolated, amplified (optionally), digested with one or more restriction endonucleases, and fragment length sizes are determined by gel electrophoresis. 
     Alternatively, allele-specific amplification technology which depends on selective PCR amplification may be used in conjunction with the instant invention. Oligonucleotides used as primers for specific amplification may carry the mutation or polymorphic region of interest in the center of the molecule (so that amplification depends on differential hybridization) (Gibbs et al (1989) Nucleic Acids Res. 17:2437-2448) or at the extreme 3′ end of one primer where, under appropriate conditions, mismatch can prevent, or reduce polymerase extension (Prossner (1993) Tibtech 11:238; WO 93/22456). In addition it may be desirable to introduce a novel restriction site in the region of the mutation to create cleavage-based detection (Gasparini et al (1992) Mol. Cell Probes 6:1). It is anticipated that in certain embodiments amplification may also be performed using Taq ligase for amplification (Barany (1991) Proc. Natl. Acad. Sci USA 88:189). In such cases, ligation will occur only if there is a perfect match at the 3′ end of the 5′ sequence making it possible to detect the presence of a known mutation at a specific site by looking for the presence or absence of amplification. 
     Nucleic Acid Sequencing 
     In yet another embodiment, any of a variety of sequencing reactions known in the art can be used to directly sequence the allele. Exemplary sequencing reactions include those based on techniques developed by Maxim and Gilbert ((1977)  Proc. Natl Acad Sci USA  74:560) or Sanger (Sanger et al (1977)  Proc. Nat. Acad. Sci. USA  74:5463). It is also contemplated that any of a variety of automated sequencing procedures may be utilized when performing the subject assays (see, for example Biotechniques (1995) 19:448), including sequencing by mass spectrometry (see, for example PCT publication WO 94/16101; Cohen et al. (1996)  Adv Chromatogr  36:127-162; and Griffin et al. (1993) Appl Biochem Biotechnol 38:147-159). It will be evident to one of skill in the art that, for certain embodiments, the occurrence of only one, two or three of the nucleic acid bases need be determined in the sequencing reaction. For instance, A-track or the like, e.g., where only one nucleic acid is detected, can be carried out. 
     Mismatch Cleavage 
     In a further embodiment, protection from cleavage agents (such as a nuclease, hydroxylamine or osmium tetraoxide and with piperidine) can be used to detect mismatched bases in RNA/RNA or RNA/DNA or DNA/DNA heteroduplexes (Myers, et al. (1985) Science 230:1242). In general, the art technique of “mismatch cleavage” starts by providing heteroduplexes formed by hybridizing (labeled) RNA or DNA containing the wild-type allele with the sample. The double-stranded duplexes are treated with an agent which cleaves single-stranded regions of the duplex such as which will exist due to base pair mismatches between the control and sample strands. For instance, RNA/DNA duplexes can be treated with RNase and DNA/DNA hybrids treated with S1 nuclease to enzymatically digest the mismatched regions. In other embodiments, either DNA/DNA or RNA/DNA duplexes can be treated with hydroxylamine or osmium tetroxide and with piperidine in order to digest mismatched regions. After digestion of the mismatched regions, the resulting material is then separated by size on denaturing polyacrylamide gels to determine the site of mutation. See, for example, Cotton et al (1988) Proc. Natl Acad Sci USA 85:4397; and Saleeba et al (1992) Methods Enzymol. 217:286295. In a preferred embodiment, the control DNA or RNA can be labeled for detection. 
     In still another embodiment, the mismatch cleavage reaction employs one or more proteins that recognize mismatched base pairs in double-stranded DNA (so called “DNA mismatch repair” enzymes). For example, the mutY enzyme of  E. coli  cleaves A at G/A mismatches and the thymidine DNA glycosylase from HeLa cells cleaves T at G/T mismatches (Hsu et al. (1994) Carcinogenesis 15:1657-1662). According to an exemplary embodiment, a probe based on an allele of a CAD-determinative gene locus haplotype is hybridized to a cDNA or other DNA product from a test cell(s). The duplex is treated with a DNA mismatch repair enzyme, and the cleavage products, if any, can be detected from electrophoresis protocols or the like. See, for example, U.S. Pat. No. 5,459,039. 
     Mobility of Nucleic Acids 
     In other embodiments, alterations in electrophoretic mobility will be used to identify a CAD-determinative allele. For example, single strand conformation polymorphism (SSCP) may be used to detect differences in electrophoretic mobility between mutant and wild type nucleic acids (Orita et al. (1989) Proc Natl. Acad. Sci. USA 86:2766, see also Cotton (1993) Mutat Res 285:125-144; and Hayashi (1992) Genet Anal Tech Appl 9:73-79). Single-stranded DNA fragments of sample and control CAD-terminative alleles are denatured and allowed to renature. The secondary structure of single-stranded nucleic acids varies according to sequence, the resulting alteration in electrophoretic mobility enables the detection of even a single base change. The DNA fragments may be labeled or detected with labeled probes. The sensitivity of the assay may be enhanced by using RNA (rather than DNA), in which the secondary structure is more sensitive to a change in sequence. In a preferred embodiment, the subject method utilizes heteroduplex analysis to separate double stranded heteroduplex molecules on the basis of changes in electrophoretic mobility (Keen et al. (1991) Trends Genet. 7:5). In yet another embodiment, the movement of alleles in polyacrylamide gels containing a gradient of denaturant is assayed using denaturing gradient gel electrophoresis (DGGE) (Myers et al. (1985) Nature 313:495). When DGGE is used as the method of analysis, DNA will be modified to insure that it does not completely denature, for example by adding a GC clamp of approximately 40 bp of high-melting GC-rich DNA by PCR. In a further embodiment, a temperature gradient is used in place of a denaturing agent gradient to identify differences in the mobility of control and sample DNA (Rosenbaum and Reissner (1987) Biophys Chem 265:12753). 
     Oligonucleotide Ligation Assay 
     In another embodiment, identification of the allelic variant is carried out using an oligonucleotide ligation assay (OLA), as described, e.g., in U.S. Pat. No. 4,998,617 and in Landegren, U. et al. ((1988) Science 241:1077-1080). The OLA protocol uses two oligonucleotides which are designed to be capable of hybridizing to abutting sequences of a single strand of a target. One of the oligonucleotides is linked to a separation marker, e.g., biotinylated, and the other is detectably labeled. If the precise complementary sequence is found in a target molecule, the oligonucleotides will hybridize such that their termini abut, and create a ligation substrate. Ligation then permits the labeled oligonucleotide to be recovered using avidin, or another biotin ligand. Nickerson, D. A. et al. have described a nucleic acid detection assay that combines attributes of PCR and OLA (Nickerson, D. A. et al. (1990) Proc. Natl. Acad. Sci. USA 87:8923-27). In this method, PCR is used to achieve the exponential amplification of target DNA, which is then detected using OLA. 
     Several techniques based on this OLA method have been developed and can be used to detect alleles of an CAD-determinative haplotype. For example, U.S. Pat. No. 5,593,826 discloses an OLA using an oligonucleotide having 3′-amino group and a 5′-phosphorylated oligonucleotide to form a conjugate having a phosphoramidate linkage. In another variation of OLA described in Tobe et al. ((1996) Nucleic Acids Res 24: 3728), OLA combined with PCR permits typing of two alleles in a single microtiter well. By marking each of the allele-specific primers with a unique hapten, i.e. digoxigenin and fluorescein, each OLA reaction can be detected by using hapten specific antibodies that are labeled with different enzyme reporters, alkaline phosphatase or horseradish peroxidase. This system permits the detection of the two alleles using a high throughput format that leads to the production of two different colors. 
     Examples of other techniques for detecting alleles include, but are not limited to, selective oligonucleotide hybridization, selective amplification, or selective primer extension. For example, oligonucleotide primers may be prepared in which the known mutation or nucleotide difference (e.g., in allelic variants) is placed centrally and then hybridized to target DNA under conditions which permit hybridization only if a perfect match is found (Saiki et al. (1986) Nature 324:163); Saiki et al (1989) Proc. Natl Acad. Sci. USA 86:6230). Such allele specific oligonucleotide hybridization techniques may be used to test one mutation or polymorphic region per reaction when oligonucleotides are hybridized to PCR amplified target DNA or a number of different mutations or polymorphic regions when the oligonucleotides are attached to the hybridizing membrane and hybridized with labeled target DNA. Other methods of detecting polymorphisms, e.g., SNPs, are known, e.g., as described in U.S. Pat. Nos. 6,410,231; 6,361,947; 6,322,980; 6,316,196; 6,258,539; and U.S. Publication Nos. 2004/0137464 and 2004/0072156. 
     V. Subjects 
     The subjects to be tested for characterizing its risk of CAD in the foregoing methods may be any human or other animal, preferably a mammal. In certain embodiments, the subject does not otherwise have an elevated risk of cardiovascular disease according to the traditional risk factors. Subjects having an elevated risk of cardiovascular disease include those with a family history of cardiovascular disease, elevated lipids, smokers, prior acute cardiovascular event, etc. (See, e.g., Harrison&#39;s Principles of Experimental Medicine, 15th Edition, McGraw-Hill, Inc., N.Y.—hereinafter “Harrison&#39;s”). 
     In certain embodiments the subject is an apparently healthy nonsmoker. “Apparently healthy”, as used herein, means individuals who have not previously being diagnosed as having any signs or symptoms indicating the presence of atherosclerosis, such as angina pectoris, history of an acute adverse cardiovascular event such as a myocardial infarction or stroke, evidence of atherosclerosis by diagnostic imaging methods including, but not limited to coronary angiography. Apparently healthy individuals also do not otherwise exhibit symptoms of disease. In other words, such individuals, if examined by a medical professional, would be characterized as healthy and free of symptoms of disease. “Nonsmoker” means an individual who, at the time of the evaluation, is not a smoker. This includes individuals who have never smoked as well as individuals who in the past have smoked but presently no longer smoke. 
     In certain embodiments, the test subjects are apparently healthy subjects otherwise free of current need for treatment for a cardiovascular disease. In some embodiments, the subject is otherwise free of symptoms calling for treatment with any one of any combination of or all of the foregoing categories of agents. For example, with respect to anti-inflammatory agents, the subject is free of symptoms of rheumatoid arthritis, chronic back pain, autoimmune diseases, vascular diseases, viral diseases, malignancies, and the like. In another embodiment, the subject is not at an elevated risk of an adverse cardiovascular event (e.g., subject with no family history of such events, subjects who are nonsmokers, subjects who are nonhyperlipidemic, subjects who do not have elevated levels of a systemic inflammatory marker), other than having an elevated level of one or more oxidized apoA-I related biomolecules. 
     In some embodiments, the subject is a nonhyperlipidemic subject. A “nonhyperlipidemic” is a subject that is a nonhypercholesterolemic and/or a nonhypertriglyceridemic subject. A “nonhypercholesterolemic” subject is one that does not fit the current criteria established for a hypercholesterolemic subject. A nonhypertriglyceridemic subject is one that does not fit the current criteria established for a hypertriglyceridemic subject (See, e.g., Harrison&#39;s Principles of Experimental Medicine, 15th Edition, McGraw-Hill, Inc., N.Y.—hereinafter “Harrison&#39;s”). Hypercholesterolemic subjects and hypertriglyceridemic subjects are associated with increased incidence of premature coronary heart disease. A hypercholesterolemic subject has an LDL level of &gt;160 mg/dL, or &gt;130 mg/dL and at least two risk factors selected from the group consisting of male gender, family history of premature coronary heart disease, cigarette smoking (more than 10 per day), hypertension, low HDL (&lt;35 mg/dL), diabetes mellitus, hyperinsulinemia, abdominal obesity, high lipoprotein (a), and personal history of cerebrovascular disease or occlusive peripheral vascular disease. A hypertriglyceridemic subject has a triglyceride (TO) level of &gt;250 mg/dL. Thus, a nonhyperlipidemic subject is defined as one whose cholesterol and triglyceride levels are below the limits set as described above for both the hypercholesterolemic and hypertriglyceridemic subjects. 
     VI. Pharmacogenomics 
     Knowledge of CAD-determinative alleles, such as those described in Tables 1-4, alone or in conjunction with information on other genetic defects contributing to CAD, al lows customization of a therapy to the individual&#39;s genetic profile. For example, subjects having an CAD-determinative allele of AIM1L, PLA2G7, OR7E29P, PLN, PTPN6, C1ORF38, GATA2, IL7R or MYLK, or any polymorphic nucleic acid sequence in linkage disequilibrium with any of these alleles, may be predisposed to developing CAD and may respond better to particular therapeutics that address the particular molecular basis of the disease in the subject. Thus, comparison of an individual&#39;s CAD-determinative allele profile to the population profile for CAD, permits the selection or design of drugs or other therapeutic regimens that are expected to be safe and efficacious for a particular subject or subject population (i.e., a group of subjects having the same genetic alteration). 
     In addition, the ability to target populations expected to show the highest clinical benefit, based on genetic profile can enable: 1) the repositioning of marketed drugs with disappointing market results; 2) the rescue of drug candidates whose clinical development has been discontinued as a result of safety or efficacy limitations, which are subject subgroup-specific; and 3) an accelerated and less costly development for drug candidates and more optimal drug labeling (e.g. since measuring the effect of various doses of an agent on a CAD causative mutation is useful for optimizing effective dose). 
     The treatment of an individual with a particular therapeutic can be monitored by determining protein, mRNA and/or transcriptional level of a CAD-determinative gene. Depending on the level detected, the therapeutic regimen can then be maintained or adjusted (increased or decreased in dose). In a preferred embodiment, the effectiveness of treating a subject with an agent comprises the steps of: (i) obtaining a preadministration sample from a subject prior to administration of the agent; (ii) detecting the level or amount of a protein, mRNA or genomic DNA in the preadministration sample of a CAD-determinative gene; (iii) obtaining one or more post-administration samples from the subject; (iv) detecting the level of expression or activity of the protein, mRNA or genomic DNA in the post-administration sample of the CAD-determinative gene; (v) comparing the level of expression or activity of the protein, mRNA or genomic DNA of the CAD-determinative gene in the preadministration sample with the corresponding one in the postadministration sample, respectively; and (vi) altering the administration of the agent to the subject accordingly. 
     Cells of a subject may also be obtained before and after administration of a therapeutic to detect the level of expression of genes other than an CAD-determinative gene to verify that the therapeutic does not increase or decrease the expression of genes which could be deleterious. This can be done, e.g., by using the method of transcriptional profiling. Thus, mRNA from cells exposed in vivo to a therapeutic and mRNA from the same type of cells that were not exposed to the therapeutic could be reverse transcribed and hybridized to a chip containing DNA from numerous genes, to thereby compare the expression of genes in cells treated and not treated with the therapeutic. 
     In still another aspect, the invention relates to a method of selecting a dose of a cardiovascular protective agent for administration to a subject. The method comprises assessing occurrence in the human&#39;s genome of a CAD-determinative allele. Occurrence of any of the polymorphisms is an indication that a greater dose of the agent should be administered to the human. The dose of the agent can be selected based on occurrence of the polymorphisms. A greater number of CAD-determinative polymorphisms indicates a greater dosage. 
     VII. Additional Diagnostic/Predictive Markers 
     In certain embodiments, assessment of one or more markers are combined to increase the predictive value of the analysis in comparison to that obtained from the identification of polymorphisms in CAD-determinative allele(s) alone. Such markers may be assessed, for example, by detecting genetic changes in the genes (e.g. mutations or polymorphisms) or by detecting the level of gene products, metabolites or other molecules level in a biological sample obtained from the subject, such as a serum or blood sample. In one embodiment, the levels of one or more markers for myocardial injury, coagulation, or atherosclerotic plaque rupture are measured from a sample from the subject to increase the predictive value of the described methods 
     In one embodiment, assessment of one or more additional markers indicative of atherosclerotic plaque rupture is combined with detection of polymorphism(s) in CAD-determinative gene(s). Markers of atherosclerotic plaque rupture that may be useful include human neutrophil elastase, inducible nitric oxide synthase, lysophosphatidic acid, malondialdehyde-modified low-density lipoprotein, matrix metalloproteinase-1, matrix metalloproteinase-2, matrix metalloproteinase-3, and matrix metalloproteinase-9. In one embodiment, assessment of one or more additional markers indicative of coagulation is combined with detection of polymorphism(s) in CAD-determinative gene(s). Coagulation markers include β-thromboglobulin, D-dimer, fibrinopeptide A, platelet-derived growth factor, plasmin-α-2-anti-plasmin complex, platelet factor 4, prothrombin fragment 1+2, P-selectin, thrombin-antithrombin III complex, thrombus precursor protein, tissue factor and von Willebrand factor. 
     In one embodiment, the marker(s) that may be tested in conjunction with the detection of polymorphism(s) in CAD-determinative gene(s) includes soluble tumor necrosis factor-α receptor-2, interleukin-6, lipoprotein-associated phospholipase A2, C-reactive protein (CRP), Creatine Kinase with Muscle and/or Brain subunits (CKMB), thrombin anti-thrombin (TAT), soluble fibrin monomer (SFM), fibrin peptide A (FPA), myoglobin, thrombin precursor protein (TPP), platelet monocyte aggregate (PMA) troponin and homocysteine. In another embodiment, the additional markers can be Annexin V, B-type natriuretic peptide (BNP) which is also called brain-type natriuretic peptide, enolase, Troponin I (TnI), cardiac-troponin T, Creatine kinase (CK), Glycogen phosphorylase (GP), Heart-type fatty acid binding protein (H-FABP), Phosphoglyceric acid mutase (PGAM) and S-100. 
     In embodiments where one or more markers are used in combination with detection of polymorphism(s) in CAD-determinative gene(s) to increase the predictive value of the analysis, the patient sample from which the level of the additional marker(s) is to be measured may be the same or different from one used to detect polymorphism(s) in CAD-determinative gene(s). In one embodiment, the biological sample from which the level of additional marker is determined is whole blood. Whole blood may be obtained from the subject using standard clinical procedures. In another embodiment, the biological sample is plasma. Plasma may be obtained from whole blood samples by centrifugation of anti-coagulated blood. Such process provides a buffy coat of white cell components and a supernatant of the plasma. In another embodiment, the biological sample is serum. Serum may be obtained by centrifugation of whole blood samples that have been collected in tubes that are free of anti-coagulant. The blood is permitted to clot prior to centrifugation. The yellowish-reddish fluid that is obtained by centrifugation is the serum. The sample may be pretreated as necessary by dilution in an appropriate buffer solution, heparinized, concentrated if desired, or fractionated by any number of methods including but not limited to ultracentrifugation, fractionation by fast performance liquid chromatography (FPLC), or precipitation of apolipoprotein B containing proteins with dextran sulfate or other methods. Any of a number of standard aqueous buffer solutions, employing one of a variety of buffers, such as phosphate, Tris, or the like, at physiological pH can be used. 
     In certain embodiments, the subject&#39;s risk profile for CAD is determined by combining a first risk value, which is obtained by determining the presence of one or more CAD-determinative polymorphisms, with one or more additional risk values to provide a final risk value. Such additional risk values may be obtained by procedures including, but not limited to, determining the subject&#39;s blood pressure, assessing the subject&#39;s response to a stress test, determining levels of myeloperoxidase, C-reactive protein, low density lipoprotein, or cholesterol in a bodily sample from the subject, or assessing the subject&#39;s atherosclerotic plaque burden. 
     In some embodiments, genetic variations in additional marker genes are combined with detection of polymorphism(s) in a gene not listed in Tables 1 or 2. In specific embodiments, the additional marker gene is selected from apolipoprotein B, apolipoprotein E, paraoxonase 1, type I angiotensin II receptor, cytochrome b-245(alpha), prothrombin, coagulation factor VII, platelet glycoprotein 1b alpha, platelet glycoprotein IIIa, endothelial nitric oxide synthase, 5,10-methylene tetrahydrofolate reductase, angiotensinogen, plasminogen activator inhibitor 1, coagulation factor V, alpha adducin I, cytochrome P450, G-protein beta, polypeptide 3, methionine synthase reductase, endothelial adhesion molecule 1 and cholesteryl ester transferase. Polymorphisms in these genes are described, for example, in U.S. Patent Publication No. 2004/0005566. 
     In one embodiment, the methods to assess the test subject&#39;s risk of developing CAD comprise performing a medical examination of the subject&#39;s cardiovascular systems. Such examinations may be useful to increase the predictive power of the methods. Types of medical examinations include, for example, coronary angiography, coronary intravascular ultrasound (IVUS), stress testing (with and without imaging), assessment of carotid intimal medial thickening, carotid ultrasound studies with or without implementation of techniques of virtual histology, coronary artery electron beam computer tomography (EBTC), cardiac computerized tomography (CT) scan, CT angiography, cardiac magnetic resonance imaging (MRI), and magnetic resonance angiography (MRA). 
     VIII. Nucleic Acids 
     The present invention provides isolated polynucleotides comprising one or more CAD-determinative polymorphic nucleic acid sequences. In some embodiments, the polymorphism is one that is described in  FIG. 1  or Tables 1-5. The isolated polynucleotides are useful in a variety of diagnostic methods. Isolated polymorphic nucleic acid molecules of the invention can be used in one or more of the following methods: a) screening assays; b) predictive medicine (e.g., diagnostic assays, prognostic assays, monitoring clinical trials, and pharmacogenetics); and c) methods of treatment (e.g., therapeutic and prophylactic). 
     An isolated polymorphic nucleic acid molecule comprises one or more polymorphisms listed in Tables 1-5. Preferred polymorphism are those found in any one of the following genes: A1M1L, PLA2G7, OR7E29P, PLN, PTPN6, C1ORF38, GATA2, IL7R, MYLK, ANPEP, PIK3R4, RPLP2, OLR1, PNPLA2, TCF4, ACP5, SELP, BAX, CPNE4, TALI, KLF15, ABCB1, LHFPL2, ITGAX, LOC389142, PLXNC1, SLA, ELL, NPY, IGSF11, ITPK1, ASB1, SELB, LOC131873, PCCA, HAPIP, PLAUR, SIDT1, RPN1, BPAG1, ROR2, MMP12, GAP43, FSTL1, MAP4, ZNF217, ALOX5, NPHP3, GPNMB, SPP1, ZNF80, MGP, C3ORF15, NEK11, POLQ, ADFP, UBXD1, 38413, FLJ46299, ZBTB20, HLA-DQA2, ZXDC, GRN, PSCD1, GYS1, C14ORF132, CD80, CDGAP, LMOD1, SLC41A3, HOXD1, STAT5A, OPRM1, 1TPR2, HIF1A, PKD2, STEAP, AGTR1, NDUFB4, GLRA3, MEF2A, STXBP5L, APOBEC3D, FMNL1, PLXND1, ATP2Cl, RUVBL1, CASR, PTPRR, SMPDL3A, APOD, APG3L, FLJ35880, TMCC1, CD96, C1QB, CTSD, FLI1, MMP9, TCIRG1, ITGB5, FLJ25414, NR1H3, HSPBAP1, APOC1, THPO, FTL, HADHSC, ALOX5AP, LAIR1, UPP1, LAPTM5, CSTA, ADCY5, PHLDB2, GM2A, NUDT16, ACSL1, VAMP5, ACP2, HLA-DPA1, TUBA3, MMP7, H41, NR112, FGFR2, GBA, CHAF1A, GSK3B, DOCK2, URB, HCLS1, CD200R1, SLCO2B1, B4GALT4, PLCXD2, FABP7, CAMKK2, FCGR1A, SELL, SELE, HNRPM, MGC45840, F5, SMTN, RAI3, HLA-DRA, CSTB, FLJ2592 and TAGLN3. 
     In a preferred embodiment, the polymorphism is from A1MIL, PLA2G7, OR7E29P, PLN, PTPN6, C1ORF38, GATA2, IL7R or MYLK. For some uses, e.g., in screening assays, CAD-determinative polymorphic nucleic acid molecules will be of at least about 15 nucleotides (nt), at least about 18 nt, at least about 20 nt, or at least about 25 nt in length, and often at least about 50 nt. Such small DNA fragments are useful as primers for polymerase chain reaction (PCR), hybridization screening, etc. Larger polynucleotide fragments, e.g., at least about 50 nt, at least about 100 nt, at least about 200 nt, at least about 300 nt, at least about 500 nt, at least about 1000 nt, at least about 1500 nt, up to the entire coding region, or up to the entire coding region plus up to about 1000 nt 5′ and/or up to about 1000 nt 3′ flanking sequences from a CAD-determinative gene, are useful for production of the encoded polypeptide, promoter motifs, etc. For use in amplification reactions, such as PCR, a pair of primers will be used. The exact composition of primer sequences is not critical to the invention, but for most applications the primers will hybridize to the subject sequence under stringent conditions, as known in the art. 
     The present invention also provides isolated nucleic acid molecules that contain one or more SNPs disclosed in Tables 1-4, and in preferred embodiments from Table 4. Preferred isolated nucleic acid molecules contain one or more SNPs identified in Tables 1-1. Isolated nucleic acid molecules containing one or more SNPs disclosed in at least one of Tables 1-4 may be interchangeably referred to throughout the present text as “SNP-containing nucleic, acid molecules.” Isolated nucleic acid molecules may optionally encode a full-length variant protein or fragment thereof. The isolated nucleic acid molecules of the present invention also include probes and primers, which may be used for assaying the disclosed SNPs, and isolated full-length genes, transcripts cDNA molecules, and fragments thereof, which may be used for such purposes as expressing an encoded protein. 
     As used herein, an “isolated nucleic acid molecule” generally is one that contains a SNP of the present invention or a complement thereof and is separated from most other nucleic acids present in the natural source of the nucleic acid molecule. Moreover, an “isolated” nucleic acid molecule, such as a cDNA molecule containing a SNP of the present invention, can be substantially free of other cellular material, or culture medium when produced by recombinant techniques, or chemical precursors or other chemicals when chemically synthesized. A nucleic acid molecule can be fused to other coding or regulatory sequences and still be considered “isolated”. Examples of “isolated” DNA molecules include recombinant DNA molecules maintained in heterologous host cells, and purified (partially or substantially) DNA molecules in solution. Isolated RNA molecules include in vivo or in vitro RNA transcripts of the isolated SNP-containing DNA molecules of the present invention. Isolated nucleic acid molecules according to the present invention further include such molecules produced synthetically. 
     Generally, an isolated SNP-containing nucleic acid molecule comprises one or more SNP positions disclosed by the present invention with flanking nucleotide sequences on either side of the SNP positions. A flanking sequence can include nucleotide residues that are naturally associated with the SNP site and/or heterologous nucleotide sequences. Preferably the flanking sequence is up to about 500, 300, 100, 60, 50, 30, 25, 20, 15, 10, 8, or 4 nucleotides (or any other length in-between) on either side of a SNP position, or as long as the full-length gene or entire protein-coding sequence (or any portion thereof such as an exon), especially if the SNP-containing nucleic acid molecule is to be used to produce a protein or protein fragment. 
     Table 4 shows SNP-containing nucleic acid molecules having 20 nucleotides flanking the SNP site. In one embodiment, the invention provides an isolated SNP-containing nucleic acid molecule comprises the nucleotide sequence of any one of SEQ ID NOs: 1-575. In another embodiment, the SNP-containing nucleic acid molecule provided by the invention comprises a nucleotide sequence identical to 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 27, 28, 29, 30, 31, 32, 34, 35, 36, 37, 38, 39, or 40 contiguous nucleotides of any one of SEQ ID NOs: 1-575. In another embodiment, the SNP-containing nucleic acid molecule provided by the invention comprises a nucleotide sequence identical to 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 27, 28, 29, 30, 31, 32, 34, 35, 36, 37, 38, 39, or 40 contiguous nucleotides of any one of SEQ ID NOs: 1-575 wherein the contiguous nucleotides contain the SNP site (shown in brackets, i.e. “[ ]” in Table 4). 
     For full-length genes and entire protein-coding sequences, a SNP flanking sequence can be, for example, up to about 5 Kb, 4 Kb, 3 Kb, 2 Kb, 1 Kb on either side of the SNP. Furthermore, in such instances, the isolated nucleic acid molecule comprises exonic sequences (including protein-coding and/or non-coding exonic sequences), but may also include intronic sequences. Thus, any protein coding sequence may be either contiguous or separated by introns. The important point is that the nucleic acid is isolated from remote and unimportant flanking sequences and is of appropriate length such that it can be subjected to the specific manipulations or uses described herein such as recombinant protein expression, preparation of probes and primers for assaying the SNP position, and other uses specific to the SNP-containing nucleic acid sequences. 
     An isolated nucleic acid molecule of the present invention further encompasses a SNP-containing polynucleotide that is the product of any one of a variety of nucleic acid amplification methods, which are used to increase the copy numbers of a polynucleotide of interest in a nucleic acid sample. Such amplification methods are well known in the art, and they include but are not limited to, polymerase chain reaction (PCR) (U.S. Pat. Nos. 4,683,195; and 4,683,202; PCR Technology: Principles and Applications for DNA Amplification, ed. H. A. Erlich, Freeman Press, NY, N.Y., 1992), ligase chain reaction (LCR) (Wu and Wallace, Genomics 4:560, 1989; Landegren et al., Science 241:1077, 1988), strand displacement amplification (SDA) (U.S. Pat. Nos. 5,270,184; and 5,422,252), transcription-mediated amplification (TMA) (U.S. Pat. No. 5,399,491), linked linear amplification (LLA) (U.S. Pat. No. 6,027,923), and the like, and isothermal amplification methods such as nucleic acid sequence based amplification (NASBA), and self-sustained sequence replication (Guatelli et al., Proc. Natl. Acad. Sci. USA 87: 1874, 1990). Based on such methodologies, a person skilled in the art can readily design primers in any suitable regions 5′ and 3′ to a SNP disclosed herein. Such primers may be used to amplify DNA of any length so long as it contains the SNP of interest in its sequence. 
     As used herein, an “amplified polynucleotide” of the invention is a SNP-containing nucleic acid molecule whose amount has been increased at least two fold by any nucleic acid amplification method performed in vitro as compared to its starting amount in a test sample. In other preferred embodiments, an amplified polynucleotide is the result of at least ten fold, fifty fold, one hundred fold, one thousand fold, or even ten thousand fold increase as compared to its starting amount in a test sample. In a typical PCR amplification, a polynucleotide of interest is often amplified at least fifty thousand fold in amount over the unamplified genomic DNA, but the precise amount of amplification needed for an assay depends on the sensitivity of the subsequent detection method used. 
     Generally, an amplified polynucleotide is at least about 16 nucleotides in length. More typically, an amplified polynucleotide is at least about 20 nucleotides in length. In a preferred embodiment of the invention, an amplified polynucleotide is at least about 30 nucleotides in length. In a more preferred embodiment of the invention, an amplified polynucleotide is at least about 32, 40, 45, 50, or, 60 nucleotides in length. In yet another preferred embodiment of the invention, an amplified polynucleotide is at least about 100, 200, 300, 400, or 500 nucleotides in length. While the total length of an amplified polynucleotide of the invention can be as long as an exon, an intron or the entire gene where the SNP of interest resides, an amplified product is typically up to about 1,000 nucleotides in length (although certain amplification methods may generate amplified products greater than 1000 nucleotides in length). More preferably, an amplified polynucleotide is not greater than about 600-700 nucleotides in length. It is understood that irrespective of the length of an amplified polynucleotide, a SNP of interest may be located anywhere along its sequence. 
     In a specific embodiment of the invention, the amplified product is at least about 21 nucleotides in length, comprises one of the transcript-based context sequences or the genomic-based context sequences shown in Tables 1-4. Such a product may have additional sequences on its 5′ end or 3′ end or both. In another embodiment, the amplified product is about 21 nucleotides in length, and it contains a SNP disclosed herein. Preferably, the SNP is located at the middle of the amplified product (e.g., at position 11 in an amplified product that is 21 nucleotides in length, or at position 51 in an amplified product that is 101 nucleotides in length), or within 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 12, 15, or 20 nucleotides from the middle of the amplified product, (however, as indicated above, the SNP of interest may be located anywhere along the length of the amplified product). 
     The present invention provides isolated nucleic acid molecules that comprise, consist of, or consist essentially of one or more polynucleotide sequences that contain one or more SNPs disclosed herein, complements thereof, and SNP-containing fragments thereof. 
     The isolated nucleic acid molecules can encode mature proteins plus additional amino or carboxyl-terminal amino acids or both, or amino acids interior to the mature peptide (when the mature form has more than one peptide chain, for instance). Such sequences may play a role in processing of a protein from precursor to a mature form, facilitate protein trafficking, prolong or shorten protein half-life, or facilitate manipulation of a protein for assay or production. As generally is the case in situ, the additional amino acids may be processed away from the mature protein by cellular enzymes. 
     Thus, the isolated nucleic acid molecules include, but are not limited to, nucleic acid molecules having a sequence encoding a peptide alone, a sequence encoding a mature peptide and additional coding sequences such as a leader or secretory sequence (e.g., a pre-pro or pro-protein sequence), a sequence encoding a mature peptide with or without additional coding sequences, plus additional non-coding sequences, for example introns and non-coding 5′ and 3′ sequences such as transcribed but untranslated sequences that play a role in, for example, transcription, mRNA processing (including splicing and polyadenylation signals), ribosome binding, and/or stability of mRNA. In addition, the nucleic acid molecules may be fused to heterologous marker sequences encoding, for example, a peptide that facilitates purification. 
     Isolated nucleic acid molecules can be in the form of RNA, such as mRNA, or in the form DNA, including cDNA and genomic DNA, which may be obtained, for example, by molecular cloning or produced by chemical synthetic techniques or by a combination thereof: (Sambrook and Russell, 2000, Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Press, NY). Furthermore, isolated nucleic acid molecules, particularly SNP detection reagents such as probes and primers, can also be partially or completely in the form of one or more types of nucleic acid analogs, such as peptide nucleic acid (PNA) (U.S. Pat. Nos. 5,539,082; 5,527,675; 5,623,049; 5,714,331). The nucleic acid, especially DNA, can be double-stranded or single-stranded. Single-stranded nucleic acid can be the coding strand (sense strand) or the complementary non-coding; from fragments of the human genome (in the case of DNA or RNA) or single nucleotides, short oligonucleotide linkers, or from a series of oligonucleotides, to provide a synthetic nucleic acid molecule. Nucleic acid molecules can be readily synthesized using the sequences provided herein as a reference; oligonucleotide and PNA oligomer synthesis techniques are well-known in the art (see, e.g., Corey, “Peptide nucleic acids: expanding the scope of nucleic acid recognition”, Trends Biotechnol. June 1997; 15(6):224-9, and Hyrup et al., “Peptide nucleic acids (PNA): synthesis, properties and potential applications”, Bioorg Med. Chem. January 1996; 4(1):5-23). Furthermore, large-scale automated oligonucleotide/PNA synthesis (including synthesis on an array or bead surface or other solid support) can readily be accomplished using commercially available nucleic acid synthesizers, such as the Applied Biosystems (Foster City, Calif.) 3900 High-Throughput DNA Synthesizer or Expedite 8909 Nucleic Acid Synthesis System, and the sequence information provided herein. 
     The present invention encompasses nucleic acid analogs that contain modified, synthetic, or non-naturally occurring nucleotides or structural elements or other alternative/modified nucleic acid chemistries known in the art. Such nucleic acid analogs are useful, for example, as detection reagents (e.g., primers/probes) for detecting one or more SNPs identified in Tables 1-4. Furthermore, kits/systems (such as beads, arrays, etc.) that include these analogs are also encompassed by the present invention. For example, PNA oligomers that are based on the polymorphic sequences of the present invention are specifically contemplated. PNA oligomers are analogs of DNA in which the phosphate backbone is replaced with a peptide-like backbone (Lagriffoul et al., Bioorganic &amp; Medicinal Chemistry Letters, 4: 1081-1082 (1994), Petersen et al., Bioorganic &amp; Medicinal Chemistry Letters, 6: 793-796 (1996), Kumar et al., Organic Letters 3(9): 1269-1272:(2001), WO96/04000). PNA hybridizes to complementary RNA or DNA with higher affinity and specificity than conventional oligonucleotides and oligonucleotide analogs. The properties of PNA enable novel molecular biology and biochemistry applications unachievable with traditional oligonucleotides and peptides. 
     Additional examples of nucleic acid modifications that improve the binding properties and/or stability of a nucleic acid include the use of base analogs such as U.S. Pat. No. 5,801,115). Thus, references herein to nucleic acid molecules, SNP-containing nucleic acid molecules, SNP detection reagents (e.g., probes and primers), oligonucleotides/polynucleotides include PNA oligomers and other nucleic acid analogs. Other examples of nucleic acid analogs and alternative/modified nucleic acid chemistries known in the art are described in Current Protocols in Nucleic Acid Chemistry, John Wiley &amp; Sons, N.Y. (2002). 
     The present invention further provides nucleic acid molecules that encode fragments of the variant polypeptides disclosed herein as well as nucleic acid molecules that encode obvious variants of such variant polypeptides. Such nucleic acid molecules may be naturally occurring, such as paralogs (different locus) and orthologs (different organism), or may be constructed by recombinant DNA methods or by chemical synthesis. Non-naturally occurring variants may be made by mutagenesis techniques, including those applied to nucleic acid molecules, cells, or organisms. Accordingly, the variants can contain nucleotide substitutions, deletions, inversions and insertions (in addition to the SNPs disclosed in Tables 1-4). Variation can occur in either or both the coding and non-coding regions. The variations can produce conservative and/or non-conservative amino acid substitutions. 
     The nucleic acid molecules of the invention may be used as probes. When used as a probe, an isolated polymorphic CAD-determinative nucleic acid molecule may comprise non-CAD-determinative nucleotide sequences, as long as the additional non-CAD-determinative nucleotide sequences do not interfere with the detection assay. A probe may comprise an isolated polymorphic CAD-determinative sequence, and any number of non-CAD-determinative nucleotide sequences, e.g., from about 1 bp to about 1 kb or more. 
     For screening purposes, hybridization probes of the polymorphic sequences may be used where both forms are present, either in separate reactions, spatially separated on a solid phase matrix, or labeled such that they can be distinguished from each other. Assays (described below) may utilize nucleic acids that hybridize to one or more of the described polymorphisms. Isolated polymorphic CAD-determinative nucleic acid molecules of the invention may be coupled (e.g., chemically conjugated), directly or indirectly (e.g., through a linker molecule) to a solid substrate. Solid substrates may be any known in the art including, but not limited to, beads, e.g., polystyrene beads; chips, e.g., glass, SiO 2 , and the like; plastic surfaces, e.g., polystyrene, polycarbonate plastic multi-well plates; and the like. 
     Additional CAD-determinative gene polymorphisms may be identified using any of a variety of methods known in the art, including, but not limited to SSCP, denaturing HPLC, and sequencing. SSCP may be used to identify additional CAD-determinative gene polymorphisms. In general, PCR primers and restriction enzymes are chosen so as to generate products in a size range of from about 25 bp to about 500 bp, or from about 100 bp to about 250 bp, or any intermediate or overlapping range therein. 
     IX. Kits 
     The invention further relates to a kit for assessing relative susceptibility of a human to developing CAD. The kit comprises reagents for assessing occurrence in the human&#39;s genome of a CAD-determinative polymorphism in at least one, two, three, four or five or more of the CAD-determinative genes. Another aspect of the invention provides kits for detecting a predisposition for developing a CAD. 
     The kits may contain one or more oligonucleotides, including 5′ and 3′ oligonucleotides that hybridize 5′ and 3′ to at least one allele of a CAD-determinative locus haplotype, such as to any of the SNPs listed in Tables 1 and 2. PCR-amplification oligonucleotides should hybridize between 25 and 2500 base pairs apart, preferably between about 100 and about 500 bases apart, in order to produce a PCR product of convenient size for subsequent analysis. 
     The design of oligonucleotides for use in the amplification and detection of CAD-determinative polymorphic alleles by the method of the invention is facilitated by the availability of public genomic data for the CAD-determinative genes. Suitable primers for the detection of a human polymorphism in these genes can be readily designed using this sequence information and standard techniques known in the art for the design and optimization of primers sequences. Optimal design of such primer sequences can be achieved, for example, by the use of commercially available primer selection programs such as Primer 2.1, Primer 3 or GeneFisher. 
     For use in a kit, oligonucleotides may be any of a variety of natural and/or synthetic compositions such as synthetic oligonucleotides, restriction fragments, cDNAs, synthetic peptide nucleic acids (PNAs), and the like. The assay kit and method may also employ labeled oligonucleotides to allow ease of identification in the assays. Examples of labels which may be employed include radio-labels, enzymes, fluorescent compounds, streptavidin, avidin, biotin, magnetic moieties, metal binding moieties, antigen or antibody moieties, and the like. 
     The kit may, optionally, also include DNA sampling means. DNA sampling means are well known to one of skill in the art and can include, but not be limited to substrates, such as filter papers, the AmpliCard™ (University of Sheffield, Sheffield, England S10 2JF; Tarlow, J W, et al.,  J. of Invest. Dematol.  103:387-389 (1994)) and the like; DNA purification reagents such as Nucleon™ kits, lysis buffers, proteinase solutions and the like; PCR reagents, such as 10× reaction buffers, thermostable polymerase, dNTPs, and the like; and allele detection means such as the HinfI restriction enzyme, allele specific oligonucleotides, degenerate oligonucleotide primers for nested PCR from dried blood. 
     A person skilled in the art will recognize that, based on the SNP and associated sequence information disclosed herein, detection reagents can be developed and used to assay any SNP of the present invention individually or in combination, and such detection reagents can be readily incorporated into one of the established kit or system formats which are well known in the art. The terms “kits” and “systems”, as used herein in the context of SNP detection reagents, are intended to refer to such things as combinations of multiple SNP detection reagents, or one or more SNP detection reagents in combination with one or more other types of elements or components (e.g., other types of biochemical reagents, containers, packages such as packaging intended for commercial sale, substrates to which SNP detection reagents are attached, electronic hardware components, etc.). Accordingly, the present invention further provides SNP detection kits and systems, including but not limited to, packaged probe and primer sets (e.g., TaqMan probe/primer sets), arrays/microarrays of nucleic acid molecules, and beads that contain one or more probes, primers, or other detection reagents for detecting one or more SNPs of the present invention. The kits/systems can optionally include various electronic hardware components; for example, arrays (“DNA chips”) and microfluidic systems (“lab-on-a-chip” systems) provided by various manufacturers typically comprise hardware components. Other kits/systems (e.g., probe/primer sets) may not include electronic hardware components, but may be comprised of, for example, one or more SNP detection reagents (along with, optionally, other biochemical reagents) packaged in one or more containers. 
     In some embodiments, a SNP detection kit typically contains one or more detection reagents and other components (e.g., a buffer, enzymes such as DNA polymerases or ligases, chain extension nucleotides such as deoxynucleotide triphosphates, and in the case of Sanger-type DNA sequencing reactions, chain terminating nucleotides, positive control sequences, negative control sequences, and the like) necessary to carry out an assay or reaction, such as amplification and/or detection of a SNP-containing nucleic acid molecule. A kit may further contain means for determining the amount of a target nucleic acid, and means for comparing the amount with a standard, and can comprise instructions for using the kit to detect the SNP-containing nucleic acid molecule of interest. In one embodiment of the present invention, kits are provided which contain the necessary reagents to carry out one or more assays to detect one or more SNPs disclosed herein. In a preferred embodiment of the present invention, SNP detection kits/systems are in the form of nucleic acid arrays, or compartmentalized kits, including microfluidic/lab-on-a-chip systems. 
     One aspect of the invention provides DNA microarrays containing one or more SNP nucleic acid molecules. In one embodiment, the microarray includes 1, 2, 3, 4, 5 or more polymorphic CAD-determinative nucleic acid molecules e.g., probes or primers described herein, that are capable of detecting (e.g., hybridizing to) a polymorphic CAD-determinative nucleic acid molecules. Isolated polymorphic CAD-determinative nucleic acid molecules can be obtained by chemical or biochemical synthesis, by recombinant DNA techniques, or by isolating the nucleic acids from a biological source, or a combination of any of the foregoing. For example, the nucleic acid may be synthesized using solid phase synthesis techniques, as are known in the art. Oligonucleotide synthesis is also described in Edge et al. (1981) Nature 292:756; Duckworth et al. (1981) Nucleic Acids Res. 9:1691 and Beaucage and Caruthers (1981) Tet. Letters 22:1859. Following preparation of the nucleic acid, the nucleic acid is then ligated to other members of the expression system to produce an expression cassette or system comprising a nucleic acid encoding the subject product in operational combination with transcriptional initiation and termination regions, which provide for expression of the nucleic acid into the subject polypeptide products under suitable conditions. 
     SNP detection kits/systems may contain, for example, one or more probes, or pairs of probes, that hybridize to a nucleic acid molecule at or near each target SNP position. Multiple pairs of allele-specific probes may be included in the kit/system to simultaneously assay large numbers of SNPs, at least one of which is a SNP of the present invention. In some kits/systems, the allele-specific probes are immobilized to a substrate such as an array or bead. For example, the same substrate can comprise allele-specific probes for detecting at least 1; 10; 100; 1000; 10,000; 100,000 (or any other number in-between) or substantially all of the SNPs shown in Tables 1-5. 
     The terms “arrays”, “microarrays”, and “DNA chips” are used herein interchangeably to refer to an array of distinct polynucleotides affixed to a substrate, such as glass, plastic, paper, nylon or other type of membrane, filter, chip, or any other suitable solid support. The polynucleotides can be synthesized directly on the substrate, or synthesized separate from the substrate and then affixed to the substrate. In one embodiment, the microarray is prepared and used according to the methods described in U.S. Pat. No. 5,837,832, Chee et al., PCT application WO95/11995 (Chee et al.), Lockhart, D. J. et al. (1996; Nat. Biotech. 14: 1675-1680) and Schena, M. et al. (1996; Proc. Natl. Acad. Sci. 93: 10614-10619), all of which are incorporated herein in their entirety by reference. In other embodiments, such arrays are produced by the methods described by Brown et al., U.S. Pat. No. 5,807,522. 
     Nucleic acid arrays are reviewed in the following references: Zammatteo et al., “New chips for molecular biology and diagnostics”, Biotechnol Annu Rev. 2002; 8:85-101; Sosnowski et al., “Active microelectronic array system for DNA hybridization, genotyping and pharmacogenomic applications”, Psychiatr Genet. December 2002; 12(4): 181-92; Heller, “DNA microarray technology: devices, systems, and applications”; Annu Rev Biomed Eng. 2002; 4: 129-53. Epub Mar. 22, 2002; Kolchirisky et al., “Analysis of SNPs and other genomic variations using gel-based chips”, Hum Mutat. April 2002; 19(4):343-60; and McGall et al., “High-density genechip oligonucleotide probe arrays”, Adv Biochem Eng Biotechnol. 2002; 77:21-42. 
     Any number of probes, such as allele-specific probes, may be implemented in an array, and each probe or pair of probes can hybridize to a different SNP position. In the case of polynucleotide probes, they can be synthesized at designated areas (or synthesized separately and then affixed to designated areas) on a substrate using a tight-directed chemical process. Each DNA chip can contain, for example, thousands to millions of individual synthetic polynucleotide probes arranged in a grid-like pattern and miniaturized (e.g., to the size of a dime). Preferably, probes are attached to a solid support in an ordered, addressable array. 
     A microarray can be composed of a large number of unique, single-stranded polynucleotides, usually either synthetic antisense polynucleotides or fragments of cDNAs, fixed to a solid support. Typical polynucleotides are preferably about 6-60 nucleotides in length, more preferably about 15-30 nucleotides in length, and most preferably about 18-25 nucleotides in length. For certain types of microarrays or other detection kits/systems, it may be preferable to use oligonucleotides that are only about 7-20 nucleotides in length. In other types of arrays, such as arrays used in conjunction with chemiluminescent detection technology, preferred probe lengths can be, for example, about 15-80 nucleotides in length, preferably about 50-70-nucleotides in length, more preferably about 5565 nucleotides in length, and most preferably about 60 nucleotides in length. The microarray or detection kit can contain polynucleotides that cover the known 5′ or 3′ sequence of a gene/transcript or target SNP site, sequential polynucleotides that cover the full-length sequence of a gene/transcript; or unique polynucleotides selected from particular areas along the length of a target gene/transcript sequence, particularly areas corresponding to one or more SNPs disclosed in Table 1 and/or Table 2. Polynucleotides used in the microarray or detection kit can be specific to a SNP or SNPs of interest (e.g., specific to a particular SNP allele at a target SNP site, or specific to particular SNP alleles at multiple different SNP sites), or specific to a polymorphic gene/transcript or genes/transcripts of interest. 
     Hybridization assays based on polynucleotide arrays rely on the differences in hybridization stability of the probes to perfectly matched and mismatched target sequence variants. For SNP genotyping, it is generally preferable that stringency conditions used in hybridization assays are high enough such that nucleic acid molecules that differ from one another at as little as a single SNP position can be differentiated (e.g., typical SNP hybridization assays are designed so that hybridization will occur only if one particular nucleotide is present at a SNP position, but will not occur if an alternative nucleotide is present at that SNP position). Such high stringency conditions may be preferable when using, for example, nucleic acid arrays of allele-specific probes for SNP detection. Such high stringency conditions are described in the preceding section, and are well known to those skilled in the art and can be found in, for example, Current Protocols in Molecular Biology, John Wiley &amp; Sons, N.Y. (1989), 6.3.1-6.3.6. 
     In other embodiments, the arrays are used in conjunction with chemiluminescent detection technology. The following patents and patent applications, which are all hereby incorporated by reference, provide additional information pertaining to chemiluminescent detection: U.S. patent application Ser. Nos. 10/620,332 and 10/620,333 describe chemiluminescent approaches for microarray detection; U.S. Pat. Nos. 6,124,478, 6,107,024, 5,994,073, 5,981,768, 5,871,938, 5,843,681, 5,800,999, and 5,773,628 describe methods and compositions of dioxetane for performing chemiluminescent detection; and U.S. Published application US2002/0110828 discloses methods and compositions for microarray controls. 
     In one embodiment of the invention, a nucleic acid array can comprise an array of probes of about 15-25 nucleotides in length. In further embodiments, a nucleic acid array can comprise any number of probes, in which at least one probe is capable of detecting one or more SNPs disclosed in Tables 1-4, and/or at least one probe comprises a fragment of one of the sequences selected from the group consisting of those disclosed in Table 1-4, the Sequence Listing, and sequences complementary thereto, said fragment comprising at least about 8 consecutive nucleotides, preferably 10, 12, 15, 16, 18, 20, more preferably 22, 25, 30, 40, 47, 50, 55, 60, 65, 70, 80, 90, 100, or more consecutive nucleotides (or any other number in-between) and containing (or being complementary to) a novel SNP allele disclosed in Table 1-4. In some embodiments, the nucleotide complementary to the SNP site is within 5, 4, 3, 2, or 1 nucleotide from the center of the probe, more preferably at the center of said probe. 
     A polynucleotide probe can be synthesized on the surface of the substrate by using a chemical coupling procedure and an ink jet application apparatus, as described in PCT application WO95/251116 (Baldeschweiler et al.) which is incorporated herein in its entirety by reference. In another aspect, a “gridded” array analogous to a dot (or slot) blot may be used to arrange and link cDNA fragments or oligonucleotides to the surface of a substrate using a vacuum system, thermal, UV, mechanical or chemical bonding procedures. An array, such as those described above, may be produced by hand or by using available devices (slot blot or dot blot apparatus), materials (any suitable solid support), and machines (including robotic instruments), and may contain 8, 24, 96, 384, 1536, 6144 or more polynucleotides, or any other, number which lends itself to the efficient use of commercially available instrumentation. 
     Using such arrays or other kits/systems, the present invention provides methods of identifying the SNPs disclosed herein in a test sample. Such methods typically involve incubating a test sample of nucleic acids with an array comprising one or more probes corresponding to at least one SNP position of the present invention, and assaying for binding of a nucleic acid from the test sample with one or more of the probes. Conditions for incubating a SNP detection reagent (or a kit/system that employs one or more such SNP detection reagents) with a test sample vary. Incubation conditions depend on such factors as the format employed in the assay, the detection methods employed, and the type and nature of the detection reagents used in the assay. One skilled in the art will recognize that any one of the commonly available hybridization, amplification and array assay formats can readily be adapted to detect the SNPs disclosed herein. 
     A SNP detection kit/system of the present invention may include components that are used to prepare nucleic acids from a test sample for the subsequent amplification and/or detection of a SNP-containing nucleic acid molecule. Such sample preparation components can be used to produce nucleic acid extracts (including DNA and/or RNA), proteins or membrane extracts from any bodily fluids (such as blood, serum, plasma, urine, saliva, phlegm, gastric juices, semen, tears, sweat, etc.), skin, hair, cells (especially nucleated cells), biopsies, buccal swabs or tissue specimens. The test samples used in the above-described methods will vary based on such factors as the assay format, nature of the detection method, and the specific tissues, cells or extracts used as the test sample to be assayed. Methods of preparing nucleic acids, proteins, and cell extracts are well known in the art and can be readily adapted to obtain a sample that is compatible with the system utilized. Automated sample preparation systems for extracting nucleic acids from a test sample are commercially available, and examples are Qiagen&#39;s BioRobot 9600, Applied Biosystems&#39; PRISM™ 6700 sample preparation system, and Roche Molecular Systems&#39; COBAS AmpliPrep System. 
     Another form of kit contemplated by the present invention is a compartmentalized kit. A compartmentalized kit includes any kit in which reagents are contained in separate containers. Such containers include, for example, small glass containers, plastic containers, strips of plastic, glass or paper, or arraying material such as silica. Such containers allow one to efficiently transfer reagents from one compartment to another compartment such that the test samples and reagents are not cross-contaminated, or from one container to another vessel not included in the kit, and the agents or solutions of each container can be added in a quantitative fashion from one compartment to another or to another vessel. Such containers may include, for example, one or more containers which will accept the test sample, one or more containers which contain at least one probe or other SNP detection reagent for detecting one or more SNPs of the present invention, one or more containers which contain wash reagents (such as phosphate buffered saline, Tris-buffers, etc.), and one or more containers which contain the reagents used to reveal the presence of the bound probe or other SNP detection reagents. The kit can optionally further comprise compartments and/or reagents for, for example, nucleic acid amplification or other enzymatic reactions such as primer extension reactions, hybridization, ligation, electrophoresis (preferably capillary electrophoresis), mass spectrometry, and/or laser-induced fluorescent detection. The kit may also include instructions for using the kit. Exemplary compartmentalized kits include microfluidic devices known in the art (see, e.g., Weigl et al., “Lab-on-a-chip for drug development”, Adv Drug Deliv Rev. Feb. 24, 2003; 55(3):349-77). In such microfluidic devices, the containers may be referred to as, for example, microfluidic “compartments”, “chambers”, or “channels”. 
     Microfluidic devices, which may also be referred to as “lab-on-a-chip” systems, biomedical micro-electro-mechanical systems (bioMEMs), or multicomponent integrated systems, are exemplary kits/systems of the present invention for analyzing SNPs. Such systems miniaturize and compartmentalize processes such as probe/target hybridization, nucleic acid amplification, and capillary electrophoresis reactions in a single functional device. Such microfluidic devices typically utilize detection reagents in at least one aspect of the system, and such detection reagents may be used to detect one or more SNPs of the present invention. One example of a microfluidic system is disclosed in U.S. Pat. No. 5,589,136, which describes the integration of PCR amplification and capillary electrophoresis in chips. Exemplary microfluidic systems comprise a pattern of microchannels designed onto a glass, silicon, quartz, or plastic wafer included on a microchip. The movements of the samples may be controlled by electric, electroosmotic or hydrostatic forces applied across different areas of the microchip to create functional microscopic valves and pumps with no moving parts. Varying the voltage can be used as a means to control the liquid flow at intersections between the micro-machined channels and to change the liquid flow rate for pumping across different sections of the microchip. See, for example, U.S. Pat. Nos. 6,153,073, Dubrow et al., and U.S. Pat. No. 6,156,181, Parce et al. 
     For genotyping SNPs, an exemplary microfluidic system may integrate, for example, nucleic acid amplification, primer extension, capillary electrophoresis, and a detection method such as laser induced fluorescence detection. In a first step of an exemplary process for using such an exemplary system, nucleic acid samples are amplified, preferably by PCR. Then, the amplification products are subjected to automated primer extension reactions using ddNTPs (specific fluorescence for each ddNTP) and the appropriate oligonucleotide primers to carry out primer extension reactions which hybridize just upstream of the targeted SNP. Once the extension at the 3′ end is completed, the primers are separated from the unincorporated fluorescent ddNTPs by capillary electrophoresis. The separation medium used in capillary electrophoresis can be, for example, polyacrylamide, polyethyleneglycol or dextran. The incorporated ddNTPs in the single nucleotide primer extension products are identified by laser-induced fluorescence detection. Such an exemplary microchip can be used to process, for example, at least 96 to 384 samples, or more, in parallel. 
     X. Therapeutic Methods 
     In another aspect, the invention features methods of treating a subject, e.g., a human, at risk of developing a cardiovascular disease, such as coronary artery disease (CAD). The methods include: identifying a subject having, or at risk of developing, CAD, and administering to the subject an agent that decreases CAD-determinative gene signaling (e.g., decreases CAD-determinative gene expression, levels or activity). 
     The present invention also relates to methods of treating a subject to reduce the risk of developing CAD or a complication from CAD. In one embodiment, the method comprises determining the presence of one or more CAD-determinative polymorphisms in the subject, and for subjects with one, two, three, four, five or more such polymorphisms, administering an agent expected to reduce the onset of cardiovascular disease. In one embodiment, the agent is selected from an anti-inflammatory agent, an antithrombotic agent, an anti-platelet agent, a fibrinolytic agent, a lipid reducing agent, a direct thrombin inhibitor, a glycoprotein Ilb/IIIa receptor inhibitor, a calcium channel blocker, a beta-adrenergic receptor blocker, a cyclooxygenase-2 inhibitor, an angiotensin system inhibitor, and/or combinations thereof. The agent is administered in an amount effective to lower the risk of the subject developing a the cardiovascular disease. 
     Anti-inflammatory agents include but are not limited to, Aldlofenac; Aldlometasone Dipropionate; Algestone Acetonide; Alpha Amylase; Amcinafal; Amcinafide; Amfenac Sodium; Amiprilose Hydrochloride; Anakinra; Anirolac; Anitrazafen; Apazone; Balsalazide Disodium; Bendazac; Benoxaprofen; Benzydamine Hydrochloride; Bromelains; Broperamole; Budesonide; Carprofen; Cicloprofen; Cintazone; Cliprofen; Clobetasol Propionate; Clobetasone Butyrate; Clopirac; Cloticasone Propionate, Cornethasone Acetate; Cortodoxone; Deflazacort; Desonide; Desoximetasone; Dexamethasone Dipropionate; Diclofenac Potassium; Diclofenac Sodium; Diflorasone Diacetate; Diflumidone Sodium; Diflunisal; Difluprednate; Diftalone; Dimethyl Sulfoxide; Drocinonide; Endrysone; Enlimomab; Enolicam Sodium; Epirizole; Etodolac; Etofenamate; Felbinac; Fenamole; Fenbufen; Fenclofenac; Fenclorac; Fendosal; Fenpipalone; Fentiazac; Flazalone; Fluazacort; Flufenamic Acid; Flumizole; Flunisolide Acetate; Flunixin; Flunixin Meglumine; Fluocortin Butyl; Fluorometholone Acetate; Fluquazone; Flurbiprofen; Fluretofen; Fluticasone Propionate; Furaprofen; Furobufen; Halcinonide; Halobetasol Propionate; Halopredone Acetate; Ibufenac; Ibuprofen; Ibuprofen Aluminum; Ibuprofen Piconol; Ilonidap; Indomethacin; Indomethacin Sodium; Indoprofen; Indoxole; Intrazole; Isoflupredone Acetate; Isoxepac; Isoxicam; Ketoprofen; Lofemizole Hydrochloride; Lomoxicam; Loteprednol Etabonate; Meclofenamate Sodium; Meclofenamic Acid; Meclorisone Dibutyrate; Mefenamic Acid; Mesalamine; Meseclazone; Methylprednisolone Suleptanate; Morniflumate; Nabumetone; Naproxen; Naproxen Sodium; Naproxol; Nimazone; Olsalazine Sodium; Orgotein; Orpanoxin; Oxaprozin; Oxyphenbutazone; Paranyline Hydrochloride; Pentosan Polysulfate Sodium; Phenbutazone Sodium Glycerate; Pirfenidone; Piroxicam; Piroxicam Cinnamate; Piroxicam Olamine; Pirprofen; Prednazate; Prifelone; Prodolic Acid; Proquazone; Proxazole; Proxazole Citrate; Rimexolone; Romazarit; Salcolex; Salnacedin; Salsalate; Salycilates; Sanguinarium Chloride; Seclazone; Sermetacin; Sudoxicam; Sulindac; Suprofen; Talmetacin; Talniflumate; Talosalate; Tebufelone; Tenidap; Tenidap Sodium; Tenoxicam; Tesicam; Tesimide; Tetrydamine; Tiopinac; Tixocortol Pivalate; Tolmetin; Tolmetin Sodium; Triclonide; Triflumidate; Zidometacin; Glucocorticoids; Zomepirac Sodium. 
     Anti-thrombotic and/or fibrinolytic agents include but are not limited to, Plasminogen (to plasmin via interactions of prekallikrein, kininogens, Factors XII, XIIIa, plasminogen proactivator, and tissue plasminogen activator[TPA]) Streptokinase; Urokinase: Anisoylated Plasminogen-Streptokinase Activator Complex; Pro-Urokinase; (Pro-UK); rTPA (alteplase or activase; r denotes recombinant); rPro-UK; Abbokinase; Eminase; Sreptase Anagrelide Hydrochloride; Bivalirudin; Dalteparin Sodium; Danaparoid Sodium; Dazoxiben Hydrochloride; Efegatran Sulfate; Enoxaparin Sodium; Ifetroban; Ifetroban Sodium; Tinzaparin Sodium; retaplase; Trifenagrel; Warfarin; Dextrans. 
     Anti-platelet agents include but are not limited to, Clopridogrel; Sulfinpyrazone; Aspirin; Dipyridamole; Clofibrate; Pyridinol Carbamate; PGE; Glucagon; Antiserotonin drugs; Caffeine; Theophyllin Pentoxifyllin; Ticlopidine; Anagrelide. 
     Lipid-reducing agents include but are not limited to, gemfibrozil, cholystyramine, colestipol, nicotinic acid, probucol lovastatin, fluvastatin, simvastatin, atorvastatin, pravastatin, cerivastatin, and other HMG-CoA reductase inhibitors. 
     Direct thrombin inhibitors include but are not limited to, hirudin, hirugen, hirulog, agatroban, PPACK, thrombin aptamers. 
     Glycoprotein IIb/IIIa receptor inhibitors are both antibodies and non-antibodies, and include but are not limited to ReoPro (abcixamab), lamifiban, tirofiban. 
     Calcium channel blockers are a chemically diverse class of compounds having important therapeutic value in the control of a variety of diseases including several cardiovascular disorders, such as hypertension, angina, and cardiac arrhythmias (Fleckenstein, Cir. Res. v. 52, (suppl. 1), p. 13-16 (1983); Fleckenstein, Experimental Facts and Therapeutic Prospects, John Wiley, New York (1983); McCall, D., Curr Pract Cardiol, v. 10, p. 1-11 (1985)). Calcium channel blockers are a heterogenous group of drugs that prevent or slow the entry of calcium into cells by regulating cellular calcium channels. (Remington, The Science and Practice of Pharmacy, Nineteenth Edition, Mack Publishing Company, Eaton, Pa., p. 963 (1995)). Most of the currently available calcium channel blockers, and useful according to the present invention, belong to one of three major chemical groups of drugs, the dihydropyridines, such as nifedipine, the phenyl alkyl amines, such as verapamil, and the benzothiazepines, such as diltiazem. Other calcium channel blockers useful according to the invention, include, but are not limited to, anrinone, amlodipine, bencyclane, felodipine, fendiline, flunarizine, isradipine, nicardipine, nimodipine, perhexylene, gallopamil, tiapamil and tiapamil analogues (such as 1993RO-11-2933), phenyloin, barbiturates, and the peptides dynorphin, omega-conotoxin, and omega-agatoxin, and the like and/or pharmaceutically acceptable salts thereof. 
     Beta-adrenergic receptor blocking agents are a class of drugs that antagonize the cardiovascular effects of catecholamines in angina pectoris, hypertension, and cardiac arrhythmias. Beta-adrenergic receptor blockers include, but are not limited to, atenolol, acebutolol, alprenolol, beftunolol, betaxolol, bunitrolol, carteolol, celiprolol, hydroxalol, indenolol, labetalol, levobunolol, mepindolol, methypranol, metindol, metoprolol, metrizoranolol, oxprenolol, pindolol, propranolol, practolol, practolol, sotalolnadolol, tiprenolol, tomalolol, timolol, bupranolol, penbutolol, trimepranol, 2-(3-(1,1-dimethylethyl)-amino-2-hyd-roxypropoxy)-3-pyridenecarbonitrilHCl, 1-butylamino-3-(2,5-dichlorophenoxy-)-2-propanol, 1-isopropylamino-3-(4-(2-cyclopropylmethoxyethyl)phenoxy)-2-propanol, 3-isopropylamino-1-(7-methylindan-4-yloxy)-2-butanol, 2-(3-t-butylamino-2-hydroxy-propylthio)-4-(5-carbamoyl-2-thienyl)thiazol, 7-(2-hydroxy-3-t-butylaminpropoxy)phthalide. The above-identified compounds can be used as isomeric mixtures, or in their respective levorotating or dextrorotating form. 
     Suitable COX-2 inhibitors include, but are not limited to, COX-2 inhibitors described in U.S. Pat. No. 5,474,995 Phenyl heterocycles as cox-2 inhibitors; U.S. Pat. No. 5,521,213 Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2; U.S. Pat. No. 5,536,752 Phenyl heterocycles as COX-2 inhibitors; U.S. Pat. No. 5,550,142 Phenyl heterocycles as COX-2 inhibitors; U.S. Pat. No. 5,552,422 Aryl substituted 5,5 fused aromatic nitrogen compounds as anti-inflammatory agents; U.S. Pat. No. 5,604,253 N-benzylindol-3-yl propanoic acid derivatives as cyclooxygenase inhibitors; U.S. Pat. No. 5,604,260 5-methanesulfonamido-1-indanones as an inhibitor of cyclooxygenase-2; U.S. Pat. No. 5,639,780 N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors; U.S. Pat. No. 5,677,318 Diphenyl-1, 2-3-thiadiazoles as anti-inflammatory agents; U.S. Pat. No. 5,691,374 Diaryl-5-oxygenated-2-(SH)-furanones as COX-2 inhibitors; U.S. Pat. No. 5,698,584 3,4-diaryl-2-hydroxy-2,5-d-ihydrofurans as prodrugs to COX-2 inhibitors; U.S. Pat. No. 5,710,140 Phenyl heterocycles as COX-2 inhibitors; U.S. Pat. No. 5,733,909 Diphenyl stilbenes as prodrugs to COX-2 inhibitors; U.S. Pat. No. 5,789,413 Alkylated styrenes as prodrugs to COX-2 inhibitors; U.S. Pat. No. 5,817,700 Bisaryl cyclobutenes derivatives as cyclooxygenase inhibitors; U.S. Pat. No. 5,849,943 Stilbene derivatives useful as cyclooxygenase-2 inhibitors; U.S. Pat. No. 5,861,419 Substituted pyridines as selective cyclooxygenase-2 inhibitors; U.S. Pat. No. 5,922,742 Pyridinyl-2-cyclopenten-1-ones as selective cyclooxygenase-2 inhibitors; U.S. Pat. No. 5,925,631 Alkylated styrenes as prodrugs to COX-2 inhibitors; all of which are commonly assigned to Merck Frost Canada, Inc. (Kirkland, Calif.). Additional COX-2 inhibitors are also described in U.S. Pat. No. 5,643,933, assigned to G. D. Searle &amp; Co. (Skokie, Ill.), entitled: Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors. 
     An angiotensin system inhibitor is an agent that interferes with the function, synthesis or catabolism of angiotensin II. These agents include, but are not limited to, angiotensin-converting enzyme (ACE) inhibitors, angiotensin II antagonists, angiotensin II receptor antagonists, agents that activate the catabolism of angiotensin II, and agents that prevent the synthesis of angiotensin I from which angiotensin II is ultimately derived. The renin-angiotensin system is involved in the regulation of hemodynamics and water and electrolyte balance. Factors that lower blood volume, renal perfusion pressure, or the concentration of Na +  in plasma tend to activate the system, while factors that increase these parameters tend to suppress its function. 
     Angiotensin (renin-angiotensin) system inhibitors are compounds that act to interfere with the production of angiotensin II from angiotensinogen or angiotensin I or interfere with the activity of angiotensin II. Such inhibitors are well known to those of ordinary skill in the art and include compounds that act to inhibit the enzymes involved in the ultimate production of angiotensin II, including renin and ACE. They also include compounds that interfere with the activity of angiotensin II, once produced. Examples of classes of such compounds include antibodies (e.g., to renin), amino acids and analogs thereof (including those conjugated to larger molecules), peptides (including peptide analogs of angiotensin and angiotensin 1), pro-renin related analogs, etc. Among the most potent and useful renin-angiotensin system inhibitors are renin inhibitors, ACE inhibitors, and angiotensin II antagonists. 
     Examples of angiotensin II antagonists include: peptidic compounds (e.g., saralasin, [(San 1 )(Val 5 )(Ala 8 )] angiotensin-(1-8) octapeptide and related analogs); N-substituted imidazole-2-one (U.S. Pat. No. 5,087,634); imidazole acetate derivatives including 2-N-butyl-4-chloro-1-(2-chlorobenzile) imidazole-5-acetic acid (see Long et al., J. Pharmacol. Exp. Ther. 247(1), 1-7 (1988)); 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid and analog derivatives (U.S. Pat. No. 4,816,463); N2-tetrazole beta-glucuronide analogs (U.S. Pat. No. 5,085,992); substituted pyrroles, pyrazoles, and tryazoles (U.S. Pat. No. 5,081,127); phenol and heterocyclic derivatives such as 1,3-imidazoles (U.S. Pat. No. 5,073,566); imidazo-fused 7-member ring heterocycles (U.S. Pat. No. 5,064,825); peptides (e.g., U.S. Pat. No. 4,772,684); antibodies to angiotensin II (e.g., U.S. Pat. No. 4,302,386); and aralkyl imidazole compounds such as biphenyl-methyl substituted imidazoles (e.g., EP Number 253,310, Jan. 20, 1988); ES8891 (N-morpholinoacetyl-(-1-naphthyl)-L-alany-1-(4, thiazolyl)-L-alanyl (35, 45)-4-amino-3-hydroxy-5-cyclo-hexapentanoyl-1-N-hexylamide, Sankyo Company, Ltd., Tokyo, Japan); SKF108566 (E-alpha-2-[2-butyl-1-(carboxy phenyl)methyl]1H-imidazole-5-yl[methyl-ane]-2-thiophenepropanoic acid, Smith Kline Beecham Pharmaceuticals, Pa.); Losartan (DUP7531MK954, DuPont Merck Pharmaceutical Company); Remikirin (RO42-5892, F. Hoffman LaRoche AG); A 2  agonists (Marion Merrill Dow) and certain non-peptide heterocycles (G. D. Searle and Company). Classes of compounds known to be useful as ACE inhibitors include acylmercapto and mercaptoalkanoyl prolines such as captopril (U.S. Pat. No. 4,105,776) and zofenopril (U.S. Pat. No. 4,316,906), carboxyalkyl dipeptides such as enalapril (U.S. Pat. No. 4,374,829), lisinopril (U.S. Pat. No. 4,374,829), quinapril (U.S. Pat. No. 4,344,949), ramipril (U.S. Pat. No. 4,587,258), and perindopril (U.S. Pat. No. 4,508,729), carboxyalkyl dipeptide mimics such as cilazapril (U.S. Pat. No. 4,512,924) and benazapril (U.S. Pat. No. 4,410,520), phosphinylalkanoyl prolines such as fosinopril (U.S. Pat. No. 4,337,201) and trandolopril. 
     Examples of renin inhibitors that are the subject of United States patents are as follows: urea derivatives of peptides (U.S. Pat. No. 5,116,835); amino acids connected by nonpeptide bonds (U.S. Pat. No. 5,114,937); di and tri peptide derivatives (U.S. Pat. No. 5,106,835); amino acids and derivatives thereof (U.S. Pat. Nos. 5,104,869 and 5,095,119); diol sulfonamides and sulfinyls (U.S. Pat. No. 5,098,924); modified peptides (U.S. Pat. No. 5,095,006); peptidyl beta-aminoacyl aminodiol carbamates (U.S. Pat. No. 5,089,471); pyrolimidazolones (U.S. Pat. No. 5,075,451); fluorine and chlorine statine or statone containing peptides (U.S. Pat. No. 5,066,643); peptidyl amino diols (U.S. Pat. Nos. 5,063,208 and 4,845,079); N-morpholino derivatives (U.S. Pat. No. 5,055,466); pepstatin derivatives (U.S. Pat. No. 4,980,283); N-heterocyclic alcohols (U.S. Pat. No. 4,885,292); monoclonal antibodies to renin (U.S. Pat. No. 4,780,401); and a variety of other peptides and analogs thereof (U.S. Pat. Nos. 5,071,837, 5,064,965, 5,063,207, 5,036,054, 5,036,053, 5,034,512, and 4,894,437). 
     XI. Predisposition Screening 
     Information on association/correlation between genotypes and disease-related phenotypes can be exploited in several ways. For example, in the case of a highly-statistically significant association between one or more SNPs with predisposition to a disease for which treatment is available, detection of such a genotype pattern in an individual may justify immediate administration of treatment, or at least the institution of regular monitoring of the individual. Even if detection of one of the SNPs of the invention did not call for immediate therapeutic intervention or monitoring in a particular individual, the subject can nevertheless be motivated to begin simple life-style changes (e.g., diet, exercise) that can be accomplished at little or no cost to the individual but would confer potential benefits in reducing the risk of developing conditions for which that individual may have an increased risk by virtue of having the CAD-susceptibility allele(s). 
     The SNPs of the invention may contribute to coronary artery disease in an individual in different ways. Some polymorphisms occur within a protein coding sequence and contribute to disease phenotype by affecting protein structure. Other polymorphisms occur in noncoding regions but may exert phenotypic effects indirectly via influence on, for example, replication, transcription, and/or translation. A single SNP may affect more than one phenotypic trait. Likewise, a single phenotypic trait may be affected by multiple SNPs in different genes. 
     As used herein, the terms “diagnose”, “diagnosis”, and “diagnostics” include, but are not limited to any of the following: detection of coronary artery disease that an individual may presently have, predisposition/susceptibility screening (i.e., determining the increased risk of an individual in developing coronary artery disease in the future, or determining whether an individual has a decreased risk of developing coronary artery disease in the future), determining a particular type or subclass of coronary artery disease in an individual known to have coronary artery disease, confirming or reinforcing a previously made diagnosis of artery disease, pharmacogenomic evaluation of an individual to determine which therapeutic strategy that individual is most likely to positively respond to or to predict whether a patient is likely to respond to a particular treatment, predicting whether a patient is likely to experience toxic effects from a particular treatment or therapeutic compound, and evaluating the future prognosis of an individual having coronary artery disease. Such diagnostic uses are based on the SNPs individually or in a unique combination or SNP haplotypes of the present invention. 
     Haplotypes are particularly useful in that, for example, fewer SNPs can be genotyped to determine if a particular genomic region harbors a locus that influences a particular phenotype, such as in linkage disequilibrium-based SNP association analysis. 
     Linkage disequilibrium (LD) refers to the co-inheritance of alleles (e.g., alternative nucleotides) at two or more different SNP sites at frequencies greater than would be expected from the separate frequencies of occurrence of each allele in a given population. The expected frequency of co-occurrence of two alleles that are inherited independently is the frequency of the first allele multiplied by the frequency of the second allele. Alleles that co-occur at expected frequencies are said to be in “linkage equilibrium”. In contrast, LD refers to any non-random genetic association between allele(s) at two or more different SNP sites, which is generally due to the physical proximity of the two loci along a chromosome. LD can occur when two or more SNPs sites are in close physical proximity to each other on a given chromosome and therefore alleles at these SNP sites will tend to remain unseparated for multiple generations with the consequence that a particular nucleotide (allele) at one SNP site will show a non-random association with a particular nucleotide (allele) at a different SNP-site located nearby. Hence, genotyping one of the SNP sites will give almost the same information as genotyping the other SNP site that is in LD. 
     Various degrees of LD can be encountered between two or more SNPs with the result being that some SNPs are more closely associated (i.e., in stronger LD) than others. Furthermore, the physical distance over which LD extends along a chromosome differs between different regions of the genome, and therefore the degree of physical separation between two or more SNP sites necessary for LD to occur can differ between different regions of the genome. 
     For diagnostic purposes and similar uses, if a particular SNP site is found to be useful for diagnosing coronary artery disease (e.g., has a significant statistical association with the condition and/or is recognized as a causative polymorphism for the condition), then the skilled artisan would recognize that other SNP sites which are in LD with this SNP site would also be useful for diagnosing the condition. Thus, polymorphisms (e.g., SNPs and/or haplotypes) that are not the actual disease-causing (causative) polymorphisms, but are in LD with such causative polymorphisms, are also useful. In such instances, the genotype of the polymorphism(s) that is/are in LD with the causative polymorphism is, predictive of the genotype of the causative polymorphism and, consequently, predictive of the phenotype (e.g., coronary artery disease) that is influenced by the causative SNP(s). Therefore, polymorphic markers that are in LD with causative polymorphisms are useful as diagnostic markers, and are particularly useful when the actual causative polymorphism(s) is/are unknown. 
     Examples of polymorphisms that can be in LD with one or more causative polymorphisms (and/or in LD with one or more polymorphisms that have a significant statistical association with a condition) and therefore useful for diagnosing the same condition that the causative/associated SNP(s) is used to diagnose, include, for example, other SNPs in the same gene, protein-coding, or mRNA transcript-coding region as the causative/associated SNP, other SNPs in the same exon or same intron as the causative/associated SNP, other SNPs in the same haplotype block as the causative/associated SNP, other SNPs in the same intergenic region as the causative/associated SNP, SNPs that are outside but near a gene (e.g., within 6 kb on either side, 5′ or 3′, of a gene boundary) that harbors a causative/associated SNP, etc. 
     Linkage disequilibrium in the human genome is reviewed in: Wall et al., “Haplotype blocks and linkage disequilibrium in the human genome”, Nat Rev Genet August 2003; 4(8):587-97; Garner et al., “On selecting markers for association studies: patterns of linkage disequilibrium between two and three diallelic loci”, Genet Epidemiol. January 2003; 24(1):57-67; Ardlie et al., “Patterns of linkage disequilibrium in the human genome”, Nat Rev Genet. April 2002; 3(4):299-309 (erratum in Nat Rev Genet July 2002; 3(7):566); and Remm et al., “High-density genotyping and linkage disequilibrium in the human genome using chromosome 22 as a model”; Curr Opin Chem. Biol. February 2002; 6(1):24-30. 
     The contribution or association of particular SNP and/or SNP haplotype with disease phenotypes, such as coronary artery disease, enables the SNPs of the present invention to be used to develop superior diagnostic tests capable of identifying individuals who express a detectable trait, such as coronary artery disease, as the result of a specific genotype, or individuals whose genotype places them at an increased or decreased risk of developing a detectable trait at a subsequent time as compared to individuals who do not have that genotype. As described herein, diagnostics may be based on a single SNP or a group of SNPs. Combined detection of a plurality of SNPs (for example, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 24, 25, 30, 32, 48, 50, 64, 96, 100, or any other number in-between, or more, of the SNPs provided in Tables 1-4) typically increases the probability of an accurate diagnosis. For example, the presence of a single SNP known to correlate with coronary artery disease might indicate a probability of 20% that an individual has or is at risk of developing coronary artery disease, whereas detection of five SNPs, each of which correlates with coronary artery disease, might indicate a probability of 80% that an individual has or is at risk of developing coronary artery disease. To further increase the accuracy of diagnosis or predisposition screening, analysis of the SNPs of the present invention can be combined with that of other polymorphisms or other risk factors of coronary artery disease, such as disease symptoms, pathological characteristics, family history, diet, environmental factors or lifestyle factors. 
     It will, of course, be understood by practitioners skilled in the treatment or diagnosis of coronary artery disease that the present invention generally does not intend to provide an absolute identification of individuals who are at risk (or less at risk) of developing coronary artery disease, and/or pathologies related to coronary artery disease, but rather to indicate a certain increased (or decreased) degree or likelihood of developing the disease based on statistically significant association results. However, this information is extremely valuable as it can be used to, for example, initiate preventive treatments or to allow an individual carrying one or more significant SNPs or SNP haplotypes to foresee warning signs such as minor clinical symptoms, or to have regularly scheduled physical exams to monitor for appearance of a condition in order to identify and begin treatment of the condition at an early stage. Particularly with diseases that are extremely debilitating or fatal if not treated on time, the knowledge of a potential predisposition, manner to treatment efficacy. 
     The diagnostic techniques of the present invention may employ a variety of methodologies to determine whether a test subject has a SNP or a SNP pattern associated with an increased or decreased risk of developing a detectable trait or whether the individual suffers from a detectable trait as a result of a particular polymorphism/mutation, including, for example, methods which enable the analysis of individual chromosomes for haplotyping, family studies, single sperm DNA analysis, or somatic hybrids. The trait analyzed using the diagnostics of the invention may be any detectable trait that is commonly observed in pathologies and disorders related to coronary artery disease. 
     Another aspect of the present invention relates to a method of determining whether an individual is at risk (or less at risk) of developing one or more traits or whether an individual expresses one or more traits as a consequence of possessing a particular trait-causing or trait-influencing allele. These methods generally involve obtaining a nucleic acid sample from an individual and assaying the nucleic acid sample to determine which nucleotide(s) is/are present at one or more SNP positions, wherein the assayed nucleotide(s) is/are indicative of an increased or decreased risk of developing the trait or indicative that the individual expresses the trait as a result of possessing a particular trait-causing or trait-influencing allele. 
     EXEMPLIFICATION 
     The invention now being generally described, it will be more readily understood by reference to the following examples, which are included merely for purposes of illustration of certain aspects and embodiments of the present invention and are not intended to be limiting in any way. 
     The contents of any patents, patent applications, patent publications, or scientific articles referenced anywhere in this application are herein incorporated by reference in their entirety. 
     Example 1 
     Identification of Human Alleles and SNPs Determinative of CAD 
     Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the United States. Among the risk factors for cardiovascular disease are behavioral (e.g.) smoking, sedentary lifestyle, or poor diet), age and health-related (e.g. diabetes, hyperlipidemia or hypertension), and genetic factors. Family history as a general marker for genetic risk is one of the most consistently identified risk factors for CVD, yet there are no examples of genes known to increase risk in even a fraction of individuals with CVD. One of the reasons that these genes are so difficult to find is that the genetic effects of any given gene are likely to be small and are likely to interact with other genes. In addition, these effects are likely to manifest themselves at different ages and stages along the CVD continuum. 
     The Approaches for Genomic Discovery in Atherosclerosis (AGENDA) study was initiated to discover genes for CVD among a large number of genes implicated in a study of gene expression in human aortas. The goal of the human disease association components of the AGENDA study is to evaluate these genes in a clinic-based sample of individuals presenting to the Duke Diagnostic Catheterization Laboratory (DDLC). Patients presenting to the DDCL have been offered the opportunity to contribute to the CATHGEN study blood bank, which houses blood, plasma and RNA samples. These samples are later matched to the diagnostic and outcome information stored in the DISSC database maintained at the Duke Clinical Research Institute. The CATHGEN subjects have consented and the samples have been collected under the appropriate authorizations from the Duke University Medical Center IRB. 
     Two sets of samples have been obtained from the CATHGEN study for analysis in the AGENDA study. These samples have been selected on the basis of CAD index (CADi, an angiographically-defined measure of disease risk) and age. The first set of samples includes 468 young affected (YA) subjects (age ≦55, CADi&gt;32), 260 older affected (OA) subjects (age &gt;55, CADi&gt;74) and 320 unaffected elderly (ON) subjects (age &gt;60, CADi&lt;23). The OA vs. ON and YA vs. ON comparisons are performed to identify genetic polymorphisms that increase susceptibility to CVD per se. The OA vs. YA comparison is performed to identify genetic polymorphisms that modify risk resulting in disease that presents at a young age, under the assumption that all individuals are at risk for CVD. 
     Over 1050 single nucleotide polymorphisms in 275 genes have been genotyped. These genes have been selected on the basis of location in the genome relative to a genetic linkage analysis of early onset coronary artery disease in families (the GENECARD study), ability to predict aortic atherosclerosis using gene expression in the human aorta, ability to predict aortic atherosclerosis in APO-E knockout mice, and published reports of genes identified through linkage analysis of CAD. 
     SNP candidates were selected using an algorithm to identify high-quality SNPs from public resources.  FIG. 1  graphically describes the algorithm used. In some cases, high-quality SNPs could not be identified from public sources, in which case, exon re-sequencing of a limited number of individuals was performed to identify de novo SNPs in target genes. 
     The statistical analysis of these variants was performed in a two-step process. First the genotypes were analyzed to evaluate the quality of the genotyping experiment. The CHG quality control protocol includes error analysis of duplicated samples arranged throughout the SNP analysis plates, evaluation of genotyping efficiency, analysis of allele frequencies and consistency with Hardy-Weinberg equilibrium. Once the SNPs were shown to meet error rate and consistency standards, the second part of the analysis was performed to evaluate association of SNP alleles and genotypes with disease status. Logistic regression was performed of diseased vs. normal or young vs. old disease adjusting for ethnicity and gender. Indicators for SNP alleles or SNP genotypes were included in the model. SNPs with model coefficients providing p-values less than 0.10 were considered interesting and worthy of additional analysis. 
     Table 1 provides an overview of the lowest p-values for each SNP. The x-axis represents location in the genome and the y-axis shows the negative log(base 10) of the lowest p-value for that SNP. Thus log p-values greater than 1.3 represent p-values less than 0.05 and log p-values greater than 2 represent p-values less than 0.01. Abbreviated gene names are included on the plot for all significant SNPs. Detailed results of this analysis are shown in Table 1: 
     
       
         
           
               
            
               
                   
               
               
                 Most Significant Logist P values Per SNP 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                 Marshfield 
                   
                   
                   
               
               
                   
                 Location 
                 genotype 
                 (cM) 
                   
                 y axis 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 PROBE 
                 LOCUS 
                 Chrom 
                 (bp) 
                 logist p-value 
                 x axis 
                 (−log 10) 
                 model 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 RS976881 
                 TNFRSF1B 
                 1 
                 11943300 
                 0.2413 
                 29.93 
                 29.93 
                 0.6174 
                 affec 
               
               
                 RS235251 
                 TNFRSF1B 
                 1 
                 11966936 
                 0.316 
                 29.93 
                 29.93 
                 0.5003 
                 affec 
               
               
                 RS3397 
                 TNFRSF1B 
                 1 
                 11976838 
                 0.8109 
                 29.93 
                 29.93 
                 0.0910 
                 young 
               
               
                 RS1892345 
                 PINK1 
                 1 
                 20426528 
                 0.2157 
                 48.53 
                 48.53 
                 0.6661 
                 affec 
               
               
                 RS7517909 
                 PINK1 
                 1 
                 20430479 
                 0.5168 
                 48.53 
                 48.53 
                 0.2867 
                 affec 
               
               
                 RS2298298 
                 PINK1 
                 1 
                 20433803 
                 0.2843 
                 48.53 
                 48.53 
                 0.5462 
                 young 
               
               
                 RS3121394 
                 PINK1 
                 1 
                 20436355 
                 0.2797 
                 48.53 
                 48.53 
                 0.5533 
                 affec 
               
               
                 RS879086 
                 PINK1 
                 1 
                 20439165 
                 0.4876 
                 48.53 
                 48.53 
                 0.3119 
                 affec 
               
               
                 RS1043424 
                 PINK1 
                 1 
                 20446475 
                 0.1911 
                 48.53 
                 48.53 
                 0.7187 
                 affec 
               
               
                 RS607254 
                 DDOST 
                 1 
                 20450355 
                 0.4739 
                 48.53 
                 48.53 
                 0.3243 
                 affec 
               
               
                 RS640742 
                 PINK1 
                 1 
                 20454029 
                 0.489 
                 48.53 
                 48.53 
                 0.3107 
                 affec 
               
               
                 RS291988 
                 C1QB 
                 1 
                 22449533 
                 
                   0.05 
                 
                 50.93 
                 50.93 
                 1.3028 
                 old 
               
               
                 RS631090 
                 C1QB 
                 1 
                 22455878 
                 
                   0.021 
                 
                 50.97 
                 50.97 
                 1.6882 
                 young 
               
               
                 RS623607 
                 C1QB 
                 1 
                 22456191 
                 0.0861 
                 50.98 
                 50.98 
                 1.0650 
                 old 
               
               
                 RS10580 
                 C1QB 
                 1 
                 22457433 
                 0.2066 
                 50.98 
                 50.98 
                 0.6849 
                 young 
               
               
                 RS292007 
                 C1QB 
                 1 
                 22460987 
                 
                   0.045 
                 
                 51.00 
                 51.00 
                 1.3458 
                 affec 
               
               
                 RS4659371 
                 AIM1L 
                 1 
                 26262249 
                 0.1168 
                 55.10 
                 55.10 
                 0.9326 
                 old 
               
               
                 RS4659431 
                 AIM1L 
                 1 
                 26263079 
                 0.0646 
                 55.10 
                 55.10 
                 1.1898 
                 old 
               
               
                 RS7517559 
                 AIM1L 
                 1 
                 26267462 
                 
                   0.036 
                 
                 55.10 
                 55.10 
                 1.4473 
                 old 
               
               
                 RS4454539 
                 AIM1L 
                 1 
                 26284951 
                 
                   0.018 
                 
                 55.10 
                 55.10 
                 1.7520 
                 young 
               
               
                 HCV1271113 
                 C1ORF38 
                 1 
                 27810572 
                 
                   0.008 
                 
                 56.50 
                 56.50 
                 2.1192 
                 old 
               
               
                 RS3766398 
                 C1ORF38 
                 1 
                 27813993 
                 
                   0.002 
                 
                 56.50 
                 56.50 
                 2.6383 
                 affec 
               
               
                 RS1467465 
                 C1ORF38 
                 1 
                 27816091 
                 0.0502 
                 56.50 
                 56.50 
                 1.2993 
                 affec 
               
               
                 RS1467464 
                 C1ORF38 
                 1 
                 27816338 
                 
                   0.004 
                 
                 56.50 
                 56.50 
                 2.4437 
                 old 
               
               
                 RS6564 
                 C1ORF38 
                 1 
                 27817663 
                 
                   0.003 
                 
                 56.50 
                 56.50 
                 2.5686 
                 old 
               
               
                 1P0259 
                 LAM5_HUMAN 
                 1 
                 30709045 
                 0.0584 
                 59.29 
                 59.29 
                 1.2336 
                 affec 
               
               
                 RS3795438 
                 LAM5_HUMAN 
                 1 
                 30709109 
                 0.0522 
                 59.29 
                 59.29 
                 1.2823 
                 old 
               
               
                 1P0258 
                 LAM5_HUMAN 
                 1 
                 30710514 
                 0.0635 
                 59.30 
                 59.30 
                 1.1972 
                 affec 
               
               
                 RS1188360 
                 LAPTM5 
                 1 
                 30714848 
                 0.2397 
                 59.32 
                 59.32 
                 0.6203 
                 young 
               
               
                 1P0257 
                 LAM5_HUMAN 
                 1 
                 30717443 
                 0.1338 
                 59.34 
                 59.34 
                 0.8735 
                 old 
               
               
                 HCV9635468 
                 LAPTM5 
                 1 
                 30717836 
                 0.3572 
                 59.34 
                 59.34 
                 0.4471 
                 old 
               
               
                 RS1188349 
                 LAM5_HUMAN 
                 1 
                 30726129 
                 0.1056 
                 59.39 
                 59.39 
                 0.9763 
                 old 
               
               
                 1P0260 
                 LAM5_HUMAN 
                 1 
                 30732520 
                 0.3152 
                 59.42 
                 59.42 
                 0.5014 
                 young 
               
               
                 RS1407882 
                 LAM5_HUMAN 
                 1 
                 30732667 
                 0.2735 
                 59.42 
                 59.42 
                 0.5630 
                 old 
               
               
                 RS2273979 
                 LAPTM5 
                 1 
                 30733140 
                 0.5827 
                 59.43 
                 59.43 
                 0.2346 
                 young 
               
               
                 RS2070929 
                 TAL1 
                 1 
                 47053524 
                 0.2556 
                 75.66 
                 75.66 
                 0.5924 
                 young 
               
               
                 RS2249665 
                 TAL1 
                 1 
                 47057001 
                 0.3905 
                 75.66 
                 75.66 
                 0.4084 
                 old 
               
               
                 RS2250495 
                 TAL1 
                 1 
                 47063294 
                 
                   0.04 
                 
                 75.66 
                 75.66 
                 1.3958 
                 young 
               
               
                 RS1050204 
                 FCGR1A 
                 1 
                 146979500 
                 0.0908 
                 155.89 
                 155.89 
                 1.0419 
                 young 
               
               
                 RS1050208 
                 FCGR1A 
                 1 
                 146979543 
                 0.9719 
                 155.89 
                 155.89 
                 0.0124 
                 affec 
               
               
                 HCV2596598 
                 GBA 
                 1 
                 152417982 
                 0.2076 
                 161.05 
                 161.05 
                 0.6828 
                 affec 
               
               
                 HCV9632667 
                 GBA 
                 1 
                 152418027 
                 0.2939 
                 161.05 
                 161.05 
                 0.5318 
                 affec 
               
               
                 RS2075569 
                 GBA 
                 1 
                 152426152 
                 0.2321 
                 161.05 
                 161.05 
                 0.6343 
                 affec 
               
               
                 RS734073 
                 GBA 
                 1 
                 152435157 
                 0.2729 
                 161.05 
                 161.05 
                 0.5640 
                 young 
               
               
                 RS1417938 
                 CRP 
                 1 
                 156900978 
                 0.205 
                 165.97 
                 165.97 
                 0.6882 
                 young 
               
               
                 RS6027 
                 F5 
                 1 
                 166670938 
                 0.281 
                 187.43 
                 187.43 
                 0.5513 
                 young 
               
               
                 RS4524 
                 F5 
                 1 
                 166699132 
                 0.1895 
                 187.46 
                 187.46 
                 0.7224 
                 old 
               
               
                 RS2040442 
                 F5 
                 1 
                 166722265 
                 0.4052 
                 187.48 
                 187.48 
                 0.3923 
                 young 
               
               
                 HCV341182 
                 F5 
                 1 
                 166732964 
                 0.5683 
                 187.49 
                 187.49 
                 0.2454 
                 young 
               
               
                 RS6128 
                 SELP 
                 1 
                 166750281 
                 0.1835 
                 187.51 
                 187.51 
                 0.7364 
                 old 
               
               
                 RS6136 
                 SELP 
                 1 
                 166751328 
                 0.065 
                 187.51 
                 187.51 
                 1.1871 
                 affec 
               
               
                 RS6133 
                 SELP 
                 1 
                 166752723 
                 
                   0.021 
                 
                 187.51 
                 187.51 
                 1.6778 
                 affec 
               
               
                 RS6132 
                 SELP 
                 1 
                 166753685 
                 
                   0.021 
                 
                 187.52 
                 187.52 
                 1.6819 
                 affec 
               
               
                 RS6131 
                 SELP 
                 1 
                 166768262 
                 0.1962 
                 187.53 
                 187.53 
                 0.7073 
                 old 
               
               
                 RS732314 
                 SELP 
                 1 
                 166786631 
                 0.4003 
                 187.55 
                 187.55 
                 0.3976 
                 old 
               
               
                 RS909628 
                 SELL 
                 1 
                 166848042 
                 0.114 
                 187.62 
                 187.62 
                 0.9431 
                 affec 
               
               
                 RS4987286 
                 SELL 
                 1 
                 166865056 
                 0.2802 
                 187.63 
                 187.63 
                 0.5525 
                 affec 
               
               
                 RS1051091 
                 SELL 
                 1 
                 166865086 
                 0.1843 
                 187.63 
                 187.63 
                 0.7345 
                 young 
               
               
                 RS689470 
                 PTGS2 
                 1 
                 183880050 
                 0.2675 
                 201.28 
                 201.28 
                 0.5727 
                 affec 
               
               
                 RS2820312 
                 LMOD1 
                 1 
                 199157514 
                 0.2171 
                 215.99 
                 215.99 
                 0.6633 
                 affec 
               
               
                 HCV1467674 
                 LMOD1 
                 1 
                 199162969 
                 0.1764 
                 215.99 
                 215.99 
                 0.7535 
                 young 
               
               
                 RS2819346 
                 LMOD1 
                 1 
                 199170344 
                 0.1355 
                 215.99 
                 215.99 
                 0.8681 
                 old 
               
               
                 RS2819366 
                 LMOD1 
                 1 
                 199196238 
                 
                   0.007 
                 
                 215.99 
                 215.99 
                 2.1367 
                 young 
               
               
                 RS903357 
                 CHI3L1 
                 1 
                 200435867 
                 0.4242 
                 216.82 
                 216.82 
                 0.3724 
                 young 
               
               
                 RS4950927 
                 CHI3L1 
                 1 
                 200436890 
                 0.9798 
                 216.82 
                 216.82 
                 0.0089 
                 old 
               
               
                 RS946259 
                 CHI3L1 
                 1 
                 200440434 
                 0.154 
                 216.82 
                 216.82 
                 0.8125 
                 old 
               
               
                 RS880633 
                 CHI3L1 
                 1 
                 200441058 
                 0.3597 
                 216.82 
                 216.82 
                 0.4441 
                 old 
               
               
                 RS7515776 
                 CHI3L1 
                 1 
                 200443960 
                 0.5349 
                 216.82 
                 216.82 
                 0.2717 
                 old 
               
               
                 RS2271627 
                 CAPG 
                 2 
                 85596599 
                 
                   0.013 
                 
                 106.17 
                 388.17 
                 1.8928 
                 old 
               
               
                 RS2271625 
                 CAPG 
                 2 
                 85600053 
                 0.2977 
                 106.18 
                 388.18 
                 0.5262 
                 young 
               
               
                 HCV2763587 
                 CAPG 
                 2 
                 85612863 
                 0.1336 
                 106.23 
                 388.23 
                 0.8742 
                 affec 
               
               
                 RS1877954 
                 CAPG 
                 2 
                 85628839 
                 0.3883 
                 106.28 
                 388.28 
                 0.4108 
                 old 
               
               
                 RS1877955 
                 CAPG 
                 2 
                 85629066 
                 0.089 
                 106.28 
                 388.28 
                 1.0506 
                 old 
               
               
                 RS12888 
                 VAMP5 
                 2 
                 85783277 
                 0.1183 
                 106.82 
                 388.82 
                 0.9270 
                 old 
               
               
                 HCV2091655 
                 VAMP5 
                 2 
                 85793028 
                 0.3619 
                 106.86 
                 388.86 
                 0.4414 
                 affec 
               
               
                 RS14976 
                 VAMP5 
                 2 
                 85793426 
                 0.1344 
                 106.86 
                 388.86 
                 0.8716 
                 old 
               
               
                 RS2228014 
                 CXCR4 
                 2 
                 137083853 
                 0.2998 
                 146.11 
                 428.11 
                 0.5232 
                 affec 
               
               
                 RS6706557 
                 CXCR4 
                 2 
                 137095930 
                 0.2892 
                 146.14 
                 428.14 
                 0.5388 
                 young 
               
               
                 RS3764917 
                 FAP 
                 2 
                 163232880 
                 0.1794 
                 166.17 
                 448.17 
                 0.7462 
                 old 
               
               
                 RS2300750 
                 FAP 
                 2 
                 163271853 
                 0.5851 
                 166.20 
                 448.20 
                 0.2328 
                 old 
               
               
                 HCV2780261 
                 c 
                 2 
                 163284939 
                 
                   0.005 
                 
                 166.20 
                 448.20 
                 2.3372 
                 old 
               
               
                 RS3788968 
                 FAP 
                 2 
                 163300144 
                 0.5832 
                 166.21 
                 448.21 
                 0.2342 
                 old 
               
               
                 RS1562315 
                 HOXD1 
                 2 
                 177248026 
                 
                   0.017 
                 
                 182.39 
                 464.39 
                 1.7670 
                 young 
               
               
                 RS1446575 
                 HOXD1 
                 2 
                 177250345 
                 0.0624 
                 182.39 
                 464.39 
                 1.2048 
                 old 
               
               
                 RS1374326 
                 HOXD1 
                 2 
                 177260860 
                 0.2378 
                 182.40 
                 464.40 
                 0.6238 
                 affec 
               
               
                 RS1026032 
                 HOXD1 
                 2 
                 177267367 
                 
                   0.028 
                 
                 182.41 
                 464.41 
                 1.5607 
                 young 
               
               
                 RS501333 
                 ASB1 
                 2 
                 239622795 
                 0.4175 
                 254.82 
                 536.82 
                 0.3793 
                 young 
               
               
                 RS489244 
                 ASB1 
                 2 
                 239627940 
                 0.1784 
                 254.83 
                 536.83 
                 0.7486 
                 young 
               
               
                 RS507812 
                 ASB1 
                 2 
                 239638400 
                 0.1181 
                 254.86 
                 536.86 
                 0.9278 
                 young 
               
               
                 RS477041 
                 ASB1 
                 2 
                 239642745 
                 0.3191 
                 254.87 
                 536.87 
                 0.4961 
                 young 
               
               
                 HCV320258 
                 GLB1 
                 3 
                 33009951 
                 0.0566 
                 60.40 
                 598.40 
                 1.2472 
                 affec 
               
               
                 HCV440839 
                 GLB1 
                 3 
                 33018248 
                 0.1269 
                 60.42 
                 598.42 
                 0.8965 
                 affec 
               
               
                 HCV143637 
                 GLB1 
                 3 
                 33034652 
                 0.0638 
                 60.47 
                 598.47 
                 1.1952 
                 old 
               
               
                 HCV78337 
                 GLB1 
                 3 
                 33047463 
                 0.2526 
                 60.50 
                 598.50 
                 0.5976 
                 affec 
               
               
                 HCV223628 
                 GLB1 
                 3 
                 33103912 
                 0.1368 
                 60.66 
                 598.66 
                 0.8639 
                 affec 
               
               
                 RS3774634 
                 CXCR6 
                 3 
                 45947034 
                 0.3307 
                 69.46 
                 607.46 
                 0.4806 
                 old 
               
               
                 RS936939 
                 CXCR6 
                 3 
                 45947215 
                 0.465 
                 69.46 
                 607.46 
                 0.3325 
                 affec 
               
               
                 HCV1929536 
                 CXCR6 
                 3 
                 45949636 
                 0.4349 
                 69.46 
                 607.46 
                 0.3616 
                 young 
               
               
                 RS2234358 
                 CXCR6 
                 3 
                 45949636 
                 0.4886 
                 69.46 
                 607.46 
                 0.3110 
                 young 
               
               
                 RS319689 
                 MAP4 
                 3 
                 47888759 
                 
                   0.016 
                 
                 70.56 
                 608.56 
                 1.8069 
                 affec 
               
               
                 RS6442089 
                 MAP4 
                 3 
                 47917016 
                 
                   0.036 
                 
                 70.58 
                 608.58 
                 1.4473 
                 young 
               
               
                 RS2230169 
                 MAP4 
                 3 
                 47918588 
                 0.0562 
                 70.58 
                 608.58 
                 1.2503 
                 young 
               
               
                 RS1060407 
                 MAP4 
                 3 
                 47918629 
                 
                   0.034 
                 
                 70.58 
                 608.58 
                 1.4698 
                 young 
               
               
                 RS2166770 
                 MAP4 
                 3 
                 47966265 
                 
                   0.008 
                 
                 70.61 
                 608.61 
                 2.1024 
                 affec 
               
               
                 RS1009316 
                 BAX 
                 3 
                 54150382 
                 0.0558 
                 70.81 
                 608.81 
                 1.2534 
                 young 
               
               
                 RS905238 
                 FTL 
                 3 
                 54157196 
                 0.0955 
                 70.82 
                 608.82 
                 1.0200 
                 affec 
               
               
                 HCV1845492 
                 PVRL3 
                 3 
                 112123926 
                 0.0928 
                 126.83 
                 664.83 
                 1.0325 
                 old 
               
               
                 RS1477848 
                 PVRL3 
                 3 
                 112138883 
                 0.0658 
                 126.83 
                 664.83 
                 1.1818 
                 young 
               
               
                 RS1477844 
                 PVRL3 
                 3 
                 112150732 
                 0.3471 
                 126.83 
                 664.83 
                 0.4595 
                 old 
               
               
                 RS1351049 
                 PVRL3 
                 3 
                 112163177 
                 
                   0.008 
                 
                 126.83 
                 664.83 
                 2.0757 
                 young 
               
               
                 RS2221065 
                 CD96 
                 3 
                 112575294 
                 0.3912 
                 126.83 
                 664.83 
                 0.4076 
                 young 
               
               
                 RS1553970 
                 CD96 
                 3 
                 112644012 
                 0.098 
                 126.87 
                 664.87 
                 1.0088 
                 young 
               
               
                 RS1877575 
                   
                 3 
                 112748356 
                 0.1576 
                 126.94 
                 664.94 
                 0.8024 
                 affec 
               
               
                 RS1282980 
                 LL5BETA 
                 3 
                 112893222 
                 
                   0.008 
                 
                 127.04 
                 665.04 
                 2.0915 
                 affec 
               
               
                 HCV3134278 
                 LL5BETA 
                 3 
                 112984829 
                 
                   0.016 
                 
                 127.10 
                 665.10 
                 1.8097 
                 old 
               
               
                 HCV1941929 
                 NP25 
                 3 
                 113041230 
                 0.0663 
                 127.13 
                 665.13 
                 1.1785 
                 young 
               
               
                 HCV9724398 
                   
                 3 
                 113128656 
                 0.358 
                 127.19 
                 665.19 
                 0.4461 
                 affec 
               
               
                 RS1492486 
                 GCET2 
                 3 
                 113168430 
                 0.1326 
                 127.22 
                 665.22 
                 0.8775 
                 young 
               
               
                 RS2029636 
                   
                 3 
                 113242673 
                 0.4073 
                 127.27 
                 665.27 
                 0.3901 
                 old 
               
               
                 RS2272022 
                 MOX2 
                 3 
                 113384751 
                 0.3569 
                 127.37 
                 665.37 
                 0.4475 
                 old 
               
               
                 HCV1195991 
                 APG3 
                 3 
                 113573291 
                 0.2683 
                 127.49 
                 665.49 
                 0.5714 
                 old 
               
               
                 HCV3129378 
                 URB 
                 3 
                 113729302 
                 0.3287 
                 127.60 
                 665.60 
                 0.4832 
                 young 
               
               
                 RS717706 
                   
                 3 
                 113781096 
                 0.096 
                 127.63 
                 665.63 
                 1.0177 
                 young 
               
               
                 HCV1483985 
                   
                 3 
                 113964461 
                 0.0555 
                 127.75 
                 665.75 
                 1.2557 
                 affec 
               
               
                 HCV3158985 
                   
                 3 
                 114046343 
                 
                   0.025 
                 
                 127.81 
                 665.81 
                 1.6073 
                 affec 
               
               
                 RS3732812 
                   
                 3 
                 114183928 
                 0.3191 
                 127.89 
                 665.89 
                 0.4961 
                 affec 
               
               
                 RS1875111 
                 BOC 
                 3 
                 114299665 
                 0.1162 
                 127.89 
                 665.89 
                 0.9348 
                 affec 
               
               
                 HCV25644981 
                   
                 3 
                 114402583 
                 0.2345 
                 127.89 
                 665.89 
                 0.6299 
                 affec 
               
               
                 HCV3040817 
                   
                 3 
                 114609331 
                 0.2661 
                 127.92 
                 665.92 
                 0.5750 
                 affec 
               
               
                 RS921741 
                 MAK3P 
                 3 
                 114764952 
                 0.1687 
                 128.07 
                 666.07 
                 0.7729 
                 old 
               
               
                 RS3773681 
                 ATP6V1A 
                 3 
                 114844802 
                 0.3954 
                 128.15 
                 666.15 
                 0.4030 
                 old 
               
               
                 HCV2056002 
                 DKFZP434C0328 
                 3 
                 114916170 
                 
                   0.014 
                 
                 128.22 
                 666.22 
                 1.8665 
                 old 
               
               
                 RS3765114 
                 MGC42530 
                 3 
                 114976108 
                 0.2955 
                 128.28 
                 666.28 
                 0.5294 
                 affec 
               
               
                 HCV9020734 
                 MGC42530 
                 3 
                 114994026 
                 0.0522 
                 128.30 
                 666.30 
                 1.2823 
                 affec 
               
               
                 RS324555 
                 KIAA1407 
                 3 
                 115051009 
                 
                   0.037 
                 
                 128.36 
                 666.36 
                 1.4306 
                 affec 
               
               
                 HCV1941287 
                 QTRTD1 
                 3 
                 115122727 
                 0.1248 
                 128.43 
                 666.43 
                 0.9038 
                 affec 
               
               
                 RS6280 
                 DRD3 
                 3 
                 115211716 
                 0.1731 
                 128.52 
                 666.52 
                 0.7617 
                 young 
               
               
                 RS3732782 
                 ZNF80 
                 3 
                 115276065 
                 
                   0.043 
                 
                 128.58 
                 666.58 
                 1.3625 
                 affec 
               
               
                 RS3732781 
                 ZNF80 
                 3 
                 115276088 
                 0.3825 
                 128.58 
                 666.58 
                 0.4174 
                 young 
               
               
                 HCV1499152 
                 ZNF80 
                 3 
                 115276221 
                 
                   0.026 
                 
                 128.58 
                 666.58 
                 1.5817 
                 affec 
               
               
                 RS3732780 
                 ZNF80 
                 3 
                 115276721 
                 0.0953 
                 128.58 
                 666.58 
                 1.0209 
                 old 
               
               
                 HCV7789260 
                 ZNF288 
                 3 
                 115387211 
                 0.1086 
                 128.69 
                 666.69 
                 0.9642 
                 young 
               
               
                 HCV74522 
                 ZNF288 
                 3 
                 115485057 
                 0.167 
                 128.79 
                 666.79 
                 0.7773 
                 affec 
               
               
                 HCV11231447 
                 ZNF288 
                 3 
                 115543280 
                 0.1496 
                 128.85 
                 666.85 
                 0.8251 
                 young 
               
               
                 HCV11239258 
                 ZNF288 
                 3 
                 115662281 
                 
                   0.024 
                 
                 128.97 
                 666.97 
                 1.6253 
                 old 
               
               
                 RS3732481 
                 ZNF288 
                 3 
                 115804314 
                 0.1899 
                 129.11 
                 667.11 
                 0.7215 
                 young 
               
               
                 RS2033406 
                 LSAMP 
                 3 
                 117386034 
                 0.1443 
                 131.83 
                 669.83 
                 0.8407 
                 affec 
               
               
                 RS10934345 
                   
                 3 
                 117530516 
                 0.1973 
                 131.87 
                 669.87 
                 0.7049 
                 affec 
               
               
                 RS2037009 
                   
                 3 
                 117948900 
                 0.1813 
                 132.70 
                 670.70 
                 0.7416 
                 old 
               
               
                 RS1133603 
                   
                 3 
                 117971681 
                 0.2437 
                 132.74 
                 670.74 
                 0.6131 
                 young 
               
               
                 RS4855909 
                   
                 3 
                 118050719 
                 0.3101 
                 132.90 
                 670.90 
                 0.5085 
                 old 
               
               
                 RS938115 
                   
                 3 
                 118096175 
                 0.1376 
                 132.99 
                 670.99 
                 0.8614 
                 young 
               
               
                 RS6788787 
                   
                 3 
                 118191749 
                 0.058 
                 133.18 
                 671.18 
                 1.2366 
                 affec 
               
               
                 RS1915585 
                   
                 3 
                 118229733 
                 
                   0.049 
                 
                 133.25 
                 671.25 
                 1.3089 
                 old 
               
               
                 RS1462845 
                   
                 3 
                 118263911 
                 0.2095 
                 133.32 
                 671.32 
                 0.6788 
                 young 
               
               
                 RS4855900 
                   
                 3 
                 118316168 
                 0.233 
                 133.42 
                 671.42 
                 0.6326 
                 affec 
               
               
                 RS1513162 
                   
                 3 
                 118455987 
                 
                   0.042 
                 
                 133.70 
                 671.70 
                 1.3726 
                 young 
               
               
                 RS7427839 
                   
                 3 
                 118486224 
                 0.2652 
                 133.76 
                 671.76 
                 0.5764 
                 old 
               
               
                 RS4643716 
                   
                 3 
                 118488473 
                 0.4683 
                 133.77 
                 671.77 
                 0.3295 
                 young 
               
               
                 RS6790819 
                   
                 3 
                 118497691 
                 0.1693 
                 133.78 
                 671.78 
                 0.7713 
                 affec 
               
               
                 RS4356827 
                   
                 3 
                 118499645 
                 0.1035 
                 133.79 
                 671.79 
                 0.9851 
                 old 
               
               
                 RS2927275 
                   
                 3 
                 118504970 
                 0.2647 
                 133.80 
                 671.80 
                 0.5772 
                 old 
               
               
                 RS1698042 
                   
                 3 
                 118506049 
                 
                   0.005 
                 
                 133.80 
                 671.80 
                 2.3468 
                 old 
               
               
                 RS1501881 
                   
                 3 
                 118510741 
                 
                   0.023 
                 
                 133.81 
                 671.81 
                 1.6326 
                 affec 
               
               
                 RS1698041 
                   
                 3 
                 118520652 
                 
                   0.01 
                 
                 133.83 
                 671.83 
                 1.9872 
                 old 
               
               
                 RS2055426 
                   
                 3 
                 118541245 
                 
                   0.003 
                 
                 133.87 
                 671.87 
                 2.5686 
                 old 
               
               
                 RS2937675 
                   
                 3 
                 118544791 
                 
                   0.002 
                 
                 133.88 
                 671.88 
                 2.6778 
                 old 
               
               
                 3ID0340 
                   
                 3 
                 118549524 
                 
                   0.005 
                 
                 133.89 
                 671.89 
                 2.2757 
                 old 
               
               
                 RS1875518 
                   
                 3 
                 118550681 
                 
                   0.004 
                 
                 133.89 
                 671.89 
                 2.4089 
                 affec 
               
               
                 RS2937673 
                   
                 3 
                 118553288 
                 
                   0.009 
                 
                 133.89 
                 671.89 
                 2.0362 
                 old 
               
               
                 RS1676232 
                   
                 3 
                 118555740 
                 
                   3E−04 
                 
                 133.90 
                 671.90 
                 3.5229 
                 old 
               
               
                 3I0311 
                   
                 3 
                 118557351 
                 0.1187 
                 133.90 
                 671.90 
                 0.9255 
                 affec 
               
               
                 RS1381801 
                   
                 3 
                 118561796 
                 0.1099 
                 133.91 
                 671.91 
                 0.9590 
                 young 
               
               
                 RS2937666 
                   
                 3 
                 118567599 
                 
                   0.007 
                 
                 133.92 
                 671.92 
                 2.1308 
                 young 
               
               
                 RS1910044 
                   
                 3 
                 118571620 
                 0.3167 
                 133.93 
                 671.93 
                 0.4994 
                 young 
               
               
                 RS6778437 
                   
                 3 
                 118584839 
                 0.0714 
                 133.99 
                 671.99 
                 1.1463 
                 young 
               
               
                 RS6795971 
                   
                 3 
                 118589894 
                 0.1006 
                 134.01 
                 672.01 
                 0.9974 
                 affec 
               
               
                 RS1466416 
                   
                 3 
                 118591707 
                 0.1335 
                 134.02 
                 672.02 
                 0.8745 
                 old 
               
               
                 RS1456186 
                   
                 3 
                 118948306 
                 0.215 
                 134.64 
                 672.64 
                 0.6676 
                 young 
               
               
                 RS843855 
                   
                 3 
                 119077436 
                 0.3914 
                 135.01 
                 673.01 
                 0.4074 
                 young 
               
               
                 RS1486336 
                   
                 3 
                 119224904 
                 
                   0.048 
                 
                 135.49 
                 673.49 
                 1.3188 
                 affec 
               
               
                 RS1499989 
                   
                 3 
                 119322105 
                 0.0984 
                 135.81 
                 673.81 
                 1.0070 
                 young 
               
               
                 RS1968010 
                   
                 3 
                 119390121 
                 0.1945 
                 136.03 
                 674.03 
                 0.7111 
                 affec 
               
               
                 RS553070 
                   
                 3 
                 119475838 
                 0.1997 
                 136.31 
                 674.31 
                 0.6996 
                 affec 
               
               
                 RS1401951 
                   
                 3 
                 119546927 
                 0.368 
                 136.32 
                 674.32 
                 0.4342 
                 young 
               
               
                 RS705233 
                   
                 3 
                 119790824 
                 0.2371 
                 136.32 
                 674.32 
                 0.6251 
                 young 
               
               
                 R5812824 
                   
                 3 
                 119875547 
                 0.1559 
                 136.36 
                 674.36 
                 0.8072 
                 young 
               
               
                 RS1521299 
                   
                 3 
                 119931630 
                 0.0874 
                 136.45 
                 674.45 
                 1.0585 
                 young 
               
               
                 RS4687959 
                 IGSF11 
                 3 
                 119944315 
                 0.0924 
                 136.47 
                 674.47 
                 1.0343 
                 affec 
               
               
                 RS6779428 
                 IGSF11 
                 3 
                 119960525 
                 0.6104 
                 136.50 
                 674.50 
                 0.2144 
                 young 
               
               
                 RS2160052 
                 IGSF11 
                 3 
                 119962780 
                 
                   0.011 
                 
                 136.50 
                 674.50 
                 1.9469 
                 old 
               
               
                 RS39688 
                   
                 3 
                 120063749 
                 0.243 
                 136.68 
                 674.68 
                 0.6144 
                 affec 
               
               
                 HCV106740 
                 UPK1B 
                 3 
                 120213944 
                 0.1641 
                 136.93 
                 674.93 
                 0.7849 
                 old 
               
               
                 HCV394161 
                 B4GALT4 
                 3 
                 120274470 
                 0.0836 
                 137.03 
                 675.03 
                 1.0778 
                 young 
               
               
                 HCV1291178 
                   
                 3 
                 120351861 
                 0.0888 
                 137.16 
                 675.16 
                 1.0516 
                 old 
               
               
                 HCV392638 
                 FLJ10902 
                 3 
                 120471737 
                 0.6869 
                 137.37 
                 675.37 
                 0.1631 
                 old 
               
               
                 RS1060569 
                 C3ORF1 
                 3 
                 120557788 
                 0.1157 
                 137.45 
                 675.45 
                 0.9367 
                 young 
               
               
                 RS25676 
                 ADPRH 
                 3 
                 120626280 
                 0.4085 
                 137.48 
                 675.48 
                 0.3888 
                 young 
               
               
                 RS1723969 
                 PLA1A 
                 3 
                 120648554 
                 0.2437 
                 137.48 
                 675.48 
                 0.6131 
                 affec 
               
               
                 RS2272269 
                 PLA1A 
                 3 
                 120652793 
                 0.3243 
                 137.49 
                 675.49 
                 0.4891 
                 affec 
               
               
                 RS2692622 
                 PLA1A 
                 3 
                 120657863 
                 0.382 
                 137.49 
                 675.49 
                 0.4179 
                 young 
               
               
                 RS2873788 
                 COX17 
                 3 
                 120699878 
                 0.2143 
                 137.50 
                 675.50 
                 0.6690 
                 affec 
               
               
                 HCV9152783 
                 NR1I2 
                 3 
                 120820408 
                 0.2415 
                 137.54 
                 675.54 
                 0.6171 
                 old 
               
               
                 HCV148571 
                 GSK3B 
                 3 
                 120931466 
                 0.149 
                 137.58 
                 675.58 
                 0.8268 
                 affec 
               
               
                 HCV1849042 
                 GSK3B 
                 3 
                 121005728 
                 0.3652 
                 137.60 
                 675.60 
                 0.4375 
                 affec 
               
               
                 RS2199503 
                 GSK3B 
                 3 
                 121099390 
                 0.1349 
                 137.63 
                 675.63 
                 0.8700 
                 young 
               
               
                 RS787204 
                   
                 3 
                 121338849 
                 0.1206 
                 137.71 
                 675.71 
                 0.9187 
                 old 
               
               
                 HCV1545736 
                 FSTL1 
                 3 
                 121435029 
                 0.092 
                 137.74 
                 675.74 
                 1.0362 
                 old 
               
               
                 RS1147707 
                 FSTL1 
                 3 
                 121490149 
                 
                   0.033 
                 
                 137.76 
                 675.76 
                 1.4763 
                 old 
               
               
                 HCV11236738 
                 NDUFB4 
                 3 
                 121635292 
                 0.265 
                 137.81 
                 675.81 
                 0.5768 
                 young 
               
               
                 RS2298958 
                 HGD 
                 3 
                 121708192 
                 0.4476 
                 137.83 
                 675.83 
                 0.3491 
                 affec 
               
               
                 RS2229308 
                 GTF2E1 
                 3 
                 121821347 
                 0.4869 
                 137.87 
                 675.87 
                 0.3126 
                 young 
               
               
                 RS470931 
                   
                 3 
                 121947330 
                 0.2619 
                 137.91 
                 675.91 
                 0.5819 
                 old 
               
               
                 HCV123952 
                   
                 3 
                 122111233 
                 0.4231 
                 137.97 
                 675.97 
                 0.3736 
                 affec 
               
               
                 RS1191299 
                   
                 3 
                 122243458 
                 0.2253 
                 138.00 
                 676.00 
                 0.6472 
                 old 
               
               
                 RS2030531 
                 POLQ 
                 3 
                 122476099 
                 0.3214 
                 138.00 
                 676.00 
                 0.4930 
                 young 
               
               
                 RS2877516 
                 POLQ 
                 3 
                 122554774 
                 0.1859 
                 138.00 
                 676.00 
                 0.7307 
                 affec 
               
               
                 RS1873645 
                 HCLS1 
                 3 
                 122669400 
                 0.2481 
                 138.00 
                 676.00 
                 0.6054 
                 old 
               
               
                 RS1128158 
                 HCLS1 
                 3 
                 122671494 
                 
                   0.048 
                 
                 138.00 
                 676.00 
                 1.3170 
                 young 
               
               
                 RS2070180 
                 HCLS1 
                 3 
                 122672239 
                 0.2809 
                 138.00 
                 676.00 
                 0.5514 
                 affec 
               
               
                 RS6807963 
                 HCLS1 
                 3 
                 122674155 
                 0.1739 
                 138.00 
                 676.00 
                 0.7597 
                 old 
               
               
                 RS3772126 
                 HCLS1 
                 3 
                 122675484 
                 
                   0.026 
                 
                 138.00 
                 676.00 
                 1.5850 
                 young 
               
               
                 RS3772127 
                 HCLS1 
                 3 
                 122675826 
                 0.2036 
                 138.00 
                 676.00 
                 0.6912 
                 old 
               
               
                 HCV1986471 
                 HCLS1 
                 3 
                 122683308 
                 0.4187 
                 138.00 
                 676.00 
                 0.3781 
                 young 
               
               
                 HCV1986466 
                 HCLS1 
                 3 
                 122694194 
                 0.0695 
                 138.00 
                 676.00 
                 1.1580 
                 young 
               
               
                 HCV11236049 
                 GOLGB1 
                 3 
                 122703105 
                 0.2023 
                 138.00 
                 676.00 
                 0.6940 
                 young 
               
               
                 RS1574115 
                 GOLGB1 
                 3 
                 122790126 
                 0.0989 
                 138.00 
                 676.00 
                 1.0048 
                 young 
               
               
                 HCV173175 
                 TRAITS 
                 3 
                 122885890 
                 0.142 
                 138.00 
                 676.00 
                 0.8477 
                 old 
               
               
                 HCV510429 
                 SLC15A2 
                 3 
                 122935076 
                 0.3797 
                 138.00 
                 676.00 
                 0.4206 
                 affec 
               
               
                 RS1920309 
                 SLC15A2 
                 3 
                 122986380 
                 
                   0.039 
                 
                 138.00 
                 676.00 
                 1.4089 
                 affec 
               
               
                 HCV180867 
                 MGC50831 
                 3 
                 123061205 
                 0.1797 
                 138.00 
                 676.00 
                 0.7455 
                 old 
               
               
                 RS2681416 
                   
                 3 
                 123138514 
                 0.1102 
                 138.00 
                 676.00 
                 0.9578 
                 young 
               
               
                 RS1501899 
                 CASR 
                 3 
                 123228229 
                 0.1182 
                 138.00 
                 676.00 
                 0.9274 
                 affec 
               
               
                 HCV1412358 
                 CASR 
                 3 
                 123237587 
                 0.075 
                 138.00 
                 676.00 
                 1.1249 
                 old 
               
               
                 HCV1412289 
                 CASR 
                 3 
                 123311158 
                 0.0583 
                 138.00 
                 676.00 
                 1.2343 
                 old 
               
               
                 RS2270917 
                 CASR 
                 3 
                 123322147 
                 0.0949 
                 138.00 
                 676.00 
                 1.0227 
                 affec 
               
               
                 NCV1412273 
                 CASR 
                 3 
                 123329454 
                 
                   0.047 
                 
                 138.00 
                 676.00 
                 1.3307 
                 old 
               
               
                 HCV1844609 
                 CSTA 
                 3 
                 123377333 
                 0.5897 
                 138.00 
                 676.00 
                 0.2294 
                 affec 
               
               
                 RS3749213 
                 WDR5B 
                 3 
                 123454731 
                 0.1845 
                 138.00 
                 676.00 
                 0.7340 
                 affec 
               
               
                 HCV23715 
                 KPNA1 
                 3 
                 123489016 
                 0.1981 
                 138.00 
                 676.00 
                 0.7031 
                 affec 
               
               
                 HCV58011 
                 BAL 
                 3 
                 123592571 
                 0.4893 
                 138.04 
                 676.04 
                 0.3104 
                 affec 
               
               
                 RS1256196 
                   
                 3 
                 123680823 
                 0.2218 
                 138.17 
                 676.17 
                 0.6540 
                 young 
               
               
                 HCV1402346 
                 HSPBAP1 
                 3 
                 123780378 
                 0.1366 
                 138.32 
                 676.32 
                 0.8645 
                 affec 
               
               
                 RS2288677 
                 DIRC2 
                 3 
                 123919192 
                 0.4153 
                 138.53 
                 676.53 
                 0.3816 
                 young 
               
               
                 HCV8993037 
                   
                 3 
                 124034412 
                 0.131 
                 138.71 
                 676.71 
                 0.8827 
                 young 
               
               
                 HCV1541693 
                 PDIR 
                 3 
                 124131457 
                 0.4211 
                 138.85 
                 676.85 
                 0.3756 
                 old 
               
               
                 RS3749286 
                 PDIR 
                 3 
                 124201092 
                 0.2756 
                 138.96 
                 676.96 
                 0.5597 
                 young 
               
               
                 HCV1541690 
                 SEC22A 
                 3 
                 124298953 
                 0.1375 
                 139.10 
                 677.10 
                 0.8617 
                 young 
               
               
                 HCV426990 
                   
                 3 
                 124327354 
                 0.0862 
                 139.14 
                 677.14 
                 1.0645 
                 young 
               
               
                 HCV11231121 
                   
                 3 
                 124365956 
                 0.6655 
                 139.17 
                 677.17 
                 0.1769 
                 old 
               
               
                 HCV3035758 
                   
                 3 
                 124497648 
                 0.0578 
                 139.30 
                 677.30 
                 1.2381 
                 affec 
               
               
                 RS2697519 
                   
                 3 
                 124612520 
                 
                   0.029 
                 
                 139.41 
                 677.41 
                 1.5421 
                 young 
               
               
                 HCV1602661 
                 MYLK 
                 3 
                 124729452 
                 
                   0.035 
                 
                 139.47 
                 677.47 
                 1.4572 
                 old 
               
               
                 HCV1602707 
                 MYLK 
                 3 
                 124824325 
                 0.1483 
                 139.49 
                 677.49 
                 0.8289 
                 old 
               
               
                 HCV1720000 
                 HAPIP 
                 3 
                 125143188 
                 
                   0.044 
                 
                 139.57 
                 677.57 
                 1.3565 
                 old 
               
               
                 HCV9532700 
                 HAPIP 
                 3 
                 125386334 
                 0.6823 
                 139.62 
                 677.62 
                 0.1660 
                 affec 
               
               
                 RS333349 
                 HAPIP 
                 3 
                 125717239 
                 0.2766 
                 139.83 
                 677.83 
                 0.5581 
                 young 
               
               
                 RS1846892 
                 HAPIP 
                 3 
                 125720194 
                 0.1978 
                 139.83 
                 677.83 
                 0.7038 
                 affec 
               
               
                 HCV1485549 
                 HAPIP 
                 3 
                 125733054 
                 
                   0.042 
                 
                 139.84 
                 677.84 
                 1.3809 
                 old 
               
               
                 HCV11792770 
                 HAPIP 
                 3 
                 125742906 
                 0.0557 
                 139.85 
                 677.85 
                 1.2541 
                 young 
               
               
                 HCV1901477 
                 UMPS 
                 3 
                 125777643 
                 0.4462 
                 139.88 
                 677.88 
                 0.3505 
                 affec 
               
               
                 HCV1901488 
                 UMPS 
                 3 
                 125783709 
                 0.4369 
                 139.89 
                 677.89 
                 0.3596 
                 affec 
               
               
                 RS674165 
                 ITGB5 
                 3 
                 125798581 
                 0.3427 
                 139.90 
                 677.90 
                 0.4651 
                 affec 
               
               
                 RS585021 
                 ITGB5 
                 3 
                 125803770 
                 0.3179 
                 139.90 
                 677.90 
                 0.4977 
                 old 
               
               
                 HCV11792629 
                 ITGB5 
                 3 
                 125831953 
                 0.3481 
                 139.93 
                 677.93 
                 0.4583 
                 affec 
               
               
                 HCV3113140 
                 ITGB5 
                 3 
                 125841936 
                 0.584 
                 139.94 
                 677.94 
                 0.2336 
                 affec 
               
               
                 RS3772840 
                 ITGB5 
                 3 
                 125871265 
                 0.2416 
                 139.96 
                 677.96 
                 0.6169 
                 affec 
               
               
                 HCV1901570 
                 ITGB5 
                 3 
                 125884474 
                 0.9204 
                 139.97 
                 677.97 
                 0.0360 
                 young 
               
               
                 HCV108358 
                 MUC13 
                 3 
                 125977596 
                 0.5084 
                 140.05 
                 678.05 
                 0.2938 
                 old 
               
               
                 RS2981534 
                   
                 3 
                 126085011 
                 0.2116 
                 140.15 
                 678.15 
                 0.6745 
                 old 
               
               
                 RS1574340 
                 SLC12A8 
                 3 
                 126123578 
                 0.6703 
                 140.18 
                 678.18 
                 0.1737 
                 young 
               
               
                 HCV1514189 
                 SLC12A8 
                 3 
                 126183586 
                 0.3824 
                 140.19 
                 678.19 
                 0.4175 
                 affec 
               
               
                 HCV1514244 
                 ZNF148 
                 3 
                 126272722 
                 0.257 
                 140.23 
                 678.23 
                 0.5901 
                 old 
               
               
                 HCV11230314 
                 OSBPL11 
                 3 
                 126585122 
                 0.6525 
                 140.72 
                 678.72 
                 0.1854 
                 affec 
               
               
                 RS2979310 
                   
                 3 
                 126709410 
                 
                   0.013 
                 
                 140.92 
                 678.92 
                 1.8928 
                 young 
               
               
                 HCV1477490 
                   
                 3 
                 127000905 
                 0.2088 
                 141.37 
                 679.37 
                 0.6803 
                 young 
               
               
                 HCV11237732 
                   
                 3 
                 127019853 
                 0.3247 
                 141.40 
                 679.40 
                 0.4885 
                 affec 
               
               
                 HCV123667 
                 FLJ20473 
                 3 
                 127124162 
                 0.4552 
                 141.57 
                 679.57 
                 0.3418 
                 old 
               
               
                 RS1868121 
                 FTHFD 
                 3 
                 127226562 
                 0.1462 
                 141.73 
                 679.73 
                 0.8351 
                 affec 
               
               
                 HCV9474551 
                 KLF15 
                 3 
                 127378591 
                 
                   4E−04 
                 
                 141.99 
                 679.99 
                 3.3979 
                 young 
               
               
                 RS777513 
                 FLJ31300 
                 3 
                 127521055 
                 0.4505 
                 142.24 
                 680.24 
                 0.3463 
                 young 
               
               
                 RS1056523 
                 C4ST3 
                 3 
                 127582116 
                 0.4658 
                 142.34 
                 680.34 
                 0.3318 
                 old 
               
               
                 RS1056522 
                 C4ST3 
                 3 
                 127582254 
                 0.1436 
                 142.34 
                 680.34 
                 0.8428 
                 young 
               
               
                 HCV1935770 
                   
                 3 
                 127673585 
                 0.5224 
                 142.50 
                 680.50 
                 0.2820 
                 young 
               
               
                 RS2053820 
                 MGC13016 
                 3 
                 127816215 
                 0.081 
                 142.75 
                 680.75 
                 1.0915 
                 young 
               
               
                 HCV1290372 
                 MGC13016 
                 3 
                 127929507 
                 0.7683 
                 142.95 
                 680.95 
                 0.1145 
                 affec 
               
               
                 HCV2067961 
                 PLXNA1 
                 3 
                 128034908 
                 0.0734 
                 143.13 
                 681.13 
                 1.1343 
                 affec 
               
               
                 RS900422 
                   
                 3 
                 128188468 
                 0.2725 
                 143.40 
                 681.40 
                 0.5646 
                 young 
               
               
                 RS1001942 
                   
                 3 
                 128452430 
                 0.5701 
                 143.86 
                 681.86 
                 0.2440 
                 young 
               
               
                 RS2720240 
                   
                 3 
                 128568283 
                 0.1387 
                 143.94 
                 681.94 
                 0.8579 
                 old 
               
               
                 RS920233 
                 TPRA40 
                 3 
                 128615993 
                 0.0618 
                 143.94 
                 681.94 
                 1.2090 
                 affec 
               
               
                 HCV7468669 
                 PODLX2 
                 3 
                 128700179 
                 0.6324 
                 143.94 
                 681.94 
                 0.1990 
                 old 
               
               
                 RS664910 
                 MGLL 
                 3 
                 128794939 
                 0.1381 
                 143.94 
                 681.94 
                 0.8598 
                 affec 
               
               
                 RS874546 
                 MGLL 
                 3 
                 128859321 
                 0.7188 
                 143.94 
                 681.94 
                 0.1434 
                 affec 
               
               
                 RS2217628 
                   
                 3 
                 128972538 
                 0.1182 
                 143.94 
                 681.94 
                 0.9274 
                 affec 
               
               
                 HCV177600 
                 RUVBL1 
                 3 
                 129138417 
                 
                   0.009 
                 
                 143.94 
                 681.94 
                 2.0362 
                 young 
               
               
                 RS2687720 
                 SELB 
                 3 
                 129239864 
                 0.2306 
                 143.94 
                 681.94 
                 0.6371 
                 old 
               
               
                 RS2955103 
                 SELB 
                 3 
                 129336145 
                 
                   0.015 
                 
                 143.94 
                 681.94 
                 1.8386 
                 young 
               
               
                 RS760383 
                 SELB 
                 3 
                 129440474 
                 0.2085 
                 143.94 
                 681.94 
                 0.6809 
                 affec 
               
               
                 HCV375170 
                 GATA2 
                 3 
                 129521443 
                 
                   0.005 
                 
                 143.94 
                 681.94 
                 2.3188 
                 affec 
               
               
                 RS1573858 
                 GATA2 
                 3 
                 129526769 
                 
                   0.002 
                 
                 143.94 
                 681.94 
                 2.8239 
                 affec 
               
               
                 RS6439129 
                 GATA2 
                 3 
                 129533682 
                 
                   0.002 
                 
                 143.94 
                 681.94 
                 2.6383 
                 affec 
               
               
                 HCV1842067 
                 GR6 
                 3 
                 129618478 
                 0.1485 
                 143.94 
                 681.94 
                 0.8283 
                 affec 
               
               
                 RS1127030 
                 RPN1 
                 3 
                 129659862 
                 
                   0.004 
                 
                 143.94 
                 681.94 
                 2.3872 
                 affec 
               
               
                 RS2712418 
                 RPN1 
                 3 
                 129664545 
                 0.2584 
                 143.94 
                 681.94 
                 0.5877 
                 affec 
               
               
                 RS2712371 
                 RPN1 
                 3 
                 129667123 
                 
                   0.004 
                 
                 143.94 
                 681.94 
                 2.4318 
                 affec 
               
               
                 RS4857914 
                 RPN1 
                 3 
                 129671593 
                 
                   0.045 
                 
                 143.94 
                 681.94 
                 1.3458 
                 affec 
               
               
                 HCV115673 
                 RAB7 
                 3 
                 129767321 
                 0.4451 
                 143.94 
                 681.94 
                 0.3515 
                 young 
               
               
                 HCV11237369 
                 RAB7 
                 3 
                 129852779 
                 0.2276 
                 143.94 
                 681.94 
                 0.6428 
                 young 
               
               
                 RS1683804 
                 NPD002 
                 3 
                 129937234 
                 0.1769 
                 143.94 
                 681.94 
                 0.7523 
                 old 
               
               
                 HCV1861453 
                   
                 3 
                 130029463 
                 0.3279 
                 143.94 
                 681.94 
                 0.4843 
                 affec 
               
               
                 RS395020 
                 FLJ12057 
                 3 
                 130065644 
                 0.3972 
                 143.94 
                 681.94 
                 0.4010 
                 affec 
               
               
                 HCV1862760 
                 ZNF9 
                 3 
                 130227866 
                 0.431 
                 143.94 
                 681.94 
                 0.3655 
                 young 
               
               
                 HCV11231355 
                 H1FX 
                 3 
                 130356394 
                 0.087 
                 143.94 
                 681.94 
                 1.0605 
                 old 
               
               
                 HCV11909732 
                 MBD4 
                 3 
                 130472576 
                 
                   0.02 
                 
                 143.94 
                 681.94 
                 1.7033 
                 old 
               
               
                 HCV8765854 
                 PLXND1 
                 3 
                 130588168 
                 0.0613 
                 143.97 
                 681.97 
                 1.2125 
                 affec 
               
               
                 RS2245285 
                 PLXND1 
                 3 
                 130607322 
                 
                   0.012 
                 
                 144.00 
                 682.00 
                 1.9245 
                 affec 
               
               
                 RS2245278 
                 PLXND1 
                 3 
                 130607544 
                 
                   0.019 
                 
                 144.00 
                 682.00 
                 1.7190 
                 affec 
               
               
                 RS2285368 
                 PLXND1 
                 3 
                 130612408 
                 0.214 
                 144.01 
                 682.01 
                 0.6696 
                 old 
               
               
                 RS2255703 
                 PLXND1 
                 3 
                 130614165 
                 0.0731 
                 144.02 
                 682.02 
                 1.1361 
                 old 
               
               
                 RS2255226 
                 PLXND1 
                 3 
                 130618132 
                 
                   0.018 
                 
                 144.02 
                 682.02 
                 1.7447 
                 affec 
               
               
                 RS2285370 
                 PLXND1 
                 3 
                 130623364 
                 0.2378 
                 144.03 
                 682.03 
                 0.6238 
                 young 
               
               
                 RS2285373 
                 PLXND1 
                 3 
                 130629118 
                 0.3172 
                 144.04 
                 682.04 
                 0.4987 
                 young 
               
               
                 HCV8765558 
                   
                 3 
                 130687872 
                 0.3718 
                 144.14 
                 682.14 
                 0.4297 
                 young 
               
               
                 RS2811343 
                   
                 3 
                 130871486 
                 
                   0.004 
                 
                 144.46 
                 682.46 
                 2.3565 
                 affec 
               
               
                 RS938194 
                   
                 3 
                 130994409 
                 0.0506 
                 144.67 
                 682.67 
                 1.2958 
                 young 
               
               
                 HCV8290655 
                   
                 3 
                 131296957 
                 
                   0.026 
                 
                 145.19 
                 683.19 
                 1.5884 
                 affec 
               
               
                 HCV8291996 
                   
                 3 
                 131387466 
                 0.1991 
                 145.34 
                 683.34 
                 0.7009 
                 affec 
               
               
                 RS322115 
                 FLJ35880 
                 3 
                 131510935 
                 0.1305 
                 145.55 
                 683.55 
                 0.8844 
                 old 
               
               
                 RS1508520 
                   
                 3 
                 131618568 
                 
                   0.001 
                 
                 145.74 
                 683.74 
                 2.9586 
                 old 
               
               
                 HCV3134777 
                 AGTR1 
                 3 
                 149741425 
                 0.1038 
                 165.32 
                 703.32 
                 0.9838 
                 affec 
               
               
                 RS2640543 
                 AGTR1 
                 3 
                 149753278 
                 0.1184 
                 165.32 
                 703.32 
                 0.9266 
                 old 
               
               
                 RS389566 
                 AGTR1 
                 3 
                 149767291 
                 0.3337 
                 165.32 
                 703.32 
                 0.4766 
                 affec 
               
               
                 HCV8758668 
                 AGTR1 
                 3 
                 149780304 
                 
                   0.039 
                 
                 165.32 
                 703.32 
                 1.4056 
                 affec 
               
               
                 RS275645 
                 AGTR1 
                 3 
                 149785363 
                 0.3124 
                 165.32 
                 703.32 
                 0.5053 
                 affec 
               
               
                 HCV11803100 
                 AGTR1 
                 3 
                 149861063 
                 0.0879 
                 165.32 
                 703.32 
                 1.0560 
                 old 
               
               
                 RS3772587 
                 AGTR1 
                 3 
                 149897825 
                 0.1834 
                 165.32 
                 703.32 
                 0.7366 
                 old 
               
               
                 RS6141 
                 THPO 
                 3 
                 185411179 
                 0.0969 
                 195.60 
                 733.60 
                 1.0137 
                 affec 
               
               
                 RS6142 
                 THPO 
                 3 
                 185412062 
                 0.1926 
                 195.60 
                 733.60 
                 0.7153 
                 old 
               
               
                 RS1801212 
                 WFS1 
                 4 
                 6367061 
                 0.2393 
                 12.14 
                 779.14 
                 0.6211 
                 affec 
               
               
                 RS1801214 
                 WFS1 
                 4 
                 6367564 
                 0.0583 
                 12.14 
                 779.14 
                 1.2343 
                 young 
               
               
                 RS734312 
                 WFS1 
                 4 
                 6367896 
                 0.242 
                 12.14 
                 779.14 
                 0.6162 
                 old 
               
               
                 RS1046314 
                 WFS1 
                 4 
                 6368497 
                 0.1159 
                 12.14 
                 779.14 
                 0.9359 
                 young 
               
               
                 RS1046316 
                 WFS1 
                 4 
                 6368629 
                 0.2628 
                 12.14 
                 779.14 
                 0.5804 
                 young 
               
               
                 HCV2674568 
                 SLA/LP 
                 4 
                 24892583 
                 0.5865 
                 38.77 
                 805.77 
                 0.2317 
                 young 
               
               
                 RS1035091 
                 SLA/LP 
                 4 
                 24902757 
                 0.1528 
                 38.77 
                 805.77 
                 0.8159 
                 affec 
               
               
                 RS5743618 
                 TLR1 
                 4 
                 38695828 
                 0.1168 
                 53.45 
                 820.45 
                 0.9326 
                 affec 
               
               
                 RS5743614 
                 TLR1 
                 4 
                 38696115 
                 0.0734 
                 53.45 
                 820.45 
                 1.1343 
                 affec 
               
               
                 RS3923647 
                 TLR1 
                 4 
                 38696719 
                 0.1077 
                 53.45 
                 820.45 
                 0.9678 
                 affec 
               
               
                 RS4833095 
                 TLR1 
                 4 
                 38696890 
                 0.1076 
                 53.45 
                 820.45 
                 0.9682 
                 affec 
               
               
                 RS5743596 
                 TLR1 
                 4 
                 38699708 
                 0.1226 
                 53.46 
                 820.46 
                 0.9115 
                 young 
               
               
                 RS5743565 
                 TLR1 
                 4 
                 38703163 
                 0.1994 
                 53.47 
                 820.47 
                 0.7003 
                 affec 
               
               
                 HCV151279 
                 SPP1 
                 4 
                 89349139 
                 
                   0.031 
                 
                 96.16 
                 863.16 
                 1.5100 
                 young 
               
               
                 RS2853744 
                 SPP1 
                 4 
                 89354643 
                 0.1428 
                 96.16 
                 863.16 
                 0.8453 
                 young 
               
               
                 HCV1840808 
                 SPP1 
                 4 
                 89354816 
                 0.1346 
                 96.16 
                 863.16 
                 0.8710 
                 young 
               
               
                 RS2853749 
                 SPP1 
                 4 
                 89356209 
                 
                   0.025 
                 
                 96.16 
                 863.16 
                 1.6038 
                 affec 
               
               
                 RS4754 
                 SPP1 
                 4 
                 89361087 
                 
                   0.024 
                 
                 96.16 
                 863.16 
                 1.6234 
                 young 
               
               
                 RS1126616 
                 SPP1 
                 4 
                 89362248 
                 
                   0.027 
                 
                 96.16 
                 863.16 
                 1.5751 
                 young 
               
               
                 RS1126772 
                 SPP1 
                 4 
                 89362581 
                 0.1167 
                 96.16 
                 863.16 
                 0.9329 
                 young 
               
               
                 RS9138 
                 SPP1 
                 4 
                 89362737 
                 
                   0.03 
                 
                 96.16 
                 863.16 
                 1.5302 
                 young 
               
               
                 RS2728116 
                 PKD2 
                 4 
                 89389445 
                 
                   0.038 
                 
                 96.16 
                 863.16 
                 1.4260 
                 affec 
               
               
                 HCV258916 
                 PKD2 
                 4 
                 89390859 
                 0.0803 
                 96.16 
                 863.16 
                 1.0953 
                 affec 
               
               
                 RS2728110 
                 PKD2 
                 4 
                 89411278 
                 
                   0.007 
                 
                 96.16 
                 863.16 
                 2.1367 
                 affec 
               
               
                 RS2725218 
                 PKD2 
                 4 
                 89418363 
                 0.1703 
                 96.16 
                 863.16 
                 0.7688 
                 affec 
               
               
                 RS2728105 
                 PKD2 
                 4 
                 89430462 
                 0.1943 
                 96.16 
                 863.16 
                 0.7115 
                 affec 
               
               
                 RS221330 
                 HADHSC 
                 4 
                 109380187 
                 0.053 
                 112.87 
                 879.87 
                 1.2757 
                 young 
               
               
                 RS141066 
                 HADHSC 
                 4 
                 109390371 
                 0.0647 
                 112.89 
                 879.89 
                 1.1891 
                 young 
               
               
                 RS763432 
                 HADHSC 
                 4 
                 109390457 
                 0.2931 
                 112.89 
                 879.89 
                 0.5330 
                 old 
               
               
                 RS732941 
                 HADHSC 
                 4 
                 109403924 
                 0.4668 
                 112.90 
                 879.90 
                 0.3309 
                 old 
               
               
                 RS221347 
                 HADHSC 
                 4 
                 109414442 
                 0.6811 
                 112.92 
                 879.92 
                 0.1668 
                 affec 
               
               
                 RS1574637 
                 NPY1R 
                 4 
                 164819719 
                 
                   0.044 
                 
                 163.24 
                 930.24 
                 1.3575 
                 affec 
               
               
                 RS9764 
                 NPY1R 
                 4 
                 164823032 
                 0.3101 
                 163.25 
                 930.25 
                 0.5085 
                 old 
               
               
                 RS5577 
                 NPY1R 
                 4 
                 164825370 
                 0.4758 
                 163.25 
                 930.25 
                 0.3226 
                 affec 
               
               
                 RS4518200 
                 NPY1R 
                 4 
                 164832049 
                 
                   0.025 
                 
                 163.26 
                 930.26 
                 1.6091 
                 affec 
               
               
                 HCV385214 
                 GLRA3 
                 4 
                 176263722 
                 0.1128 
                 176.19 
                 943.19 
                 0.9477 
                 young 
               
               
                 HCV9539364 
                 GLRA3 
                 4 
                 176274606 
                 0.235 
                 176.19 
                 943.19 
                 0.6289 
                 old 
               
               
                 HCV8299063 
                 GLRA3 
                 4 
                 176303082 
                 0.2026 
                 176.19 
                 943.19 
                 0.6934 
                 affec 
               
               
                 RS2046485 
                 GLRA3 
                 4 
                 176355509 
                 0.6248 
                 176.19 
                 943.19 
                 0.2043 
                 young 
               
               
                 RS3749233 
                 ACSL1 
                 4 
                 186383123 
                 
                   0.037 
                 
                 198.10 
                 965.10 
                 1.4318 
                 old 
               
               
                 HCV1170089 
                 ACSL1 
                 4 
                 186391214 
                 
                   0.025 
                 
                 198.18 
                 965.18 
                 1.6003 
                 affec 
               
               
                 HCV1170063 
                 ACSL1 
                 4 
                 186419601 
                 
                   0.018 
                 
                 198.43 
                 965.43 
                 1.7375 
                 affec 
               
               
                 RS2280297 
                 ACSL1 
                 4 
                 186432003 
                 
                   0.03 
                 
                 198.54 
                 965.54 
                 1.5229 
                 old 
               
               
                 HCV2390582 
                 MATP 
                 5 
                 34018032 
                 0.1542 
                 49.98 
                 1022.98 
                 0.8119 
                 young 
               
               
                 RS2228140 
                 IL7R 
                 5 
                 35871330 
                 
                   0.024 
                 
                 52.55 
                 1025.55 
                 1.6253 
                 old 
               
               
                 RS1494555 
                 IL7R 
                 5 
                 35916691 
                 
                   0.023 
                 
                 52.55 
                 1025.55 
                 1.6308 
                 old 
               
               
                 RS2270555 
                 IL7R 
                 5 
                 35916774 
                 0.2835 
                 52.55 
                 1025.55 
                 0.5474 
                 affec 
               
               
                 RS987106 
                 IL7R 
                 5 
                 35921094 
                 0.0903 
                 52.55 
                 1025.55 
                 1.0443 
                 old 
               
               
                 RS3194051 
                 IL7R 
                 5 
                 35921775 
                 0.4191 
                 52.55 
                 1025.55 
                 0.3777 
                 affec 
               
               
                 RS1050674 
                 LHFPL2 
                 5 
                 77867162 
                 
                   0.037 
                 
                 83.09 
                 1056.09 
                 1.4306 
                 young 
               
               
                 HCV3263440 
                 LHFPL2 
                 5 
                 77899327 
                 
                   0.042 
                 
                 83.12 
                 1056.12 
                 1.3726 
                 young 
               
               
                 HCV3263427 
                 LHFPL2 
                 5 
                 77913885 
                 0.1637 
                 83.14 
                 1056.14 
                 0.7860 
                 old 
               
               
                 HCV3263409 
                 LHFPL2 
                 5 
                 77926977 
                 0.2523 
                 83.16 
                 1056.16 
                 0.5981 
                 old 
               
               
                 RS1561735 
                 LHFPL2 
                 5 
                 77950301 
                 
                   0.029 
                 
                 83.18 
                 1056.18 
                 1.5331 
                 old 
               
               
                 HCV2084766 
                 ADRB2 
                 5 
                 148235156 
                 0.0686 
                 150.34 
                 1123.34 
                 1.1637 
                 affec 
               
               
                 RS2277028 
                 GM2A 
                 5 
                 150661186 
                 0.0828 
                 154.43 
                 1127.43 
                 1.0820 
                 old 
               
               
                 5P0001GM2A 
                 GM2A 
                 5 
                 150667919 
                 0.0948 
                 154.45 
                 1127.45 
                 1.0232 
                 old 
               
               
                 RS153478 
                 GM2A 
                 5 
                 150667949 
                 0.1278 
                 154.45 
                 1127.45 
                 0.8935 
                 old 
               
               
                 RS248465 
                 GM2A 
                 5 
                 150671563 
                 0.0875 
                 154.45 
                 1127.45 
                 1.0580 
                 young 
               
               
                 5P0002GM2A 
                 GM2A 
                 5 
                 150675246 
                 0.5203 
                 154.46 
                 1127.46 
                 0.2837 
                 old 
               
               
                 RS2075783 
                 GM2A 
                 5 
                 150675290 
                 0.1292 
                 154.46 
                 1127.46 
                 0.8887 
                 old 
               
               
                 RS1048723 
                 GM2A 
                 5 
                 150675522 
                 0.4374 
                 154.46 
                 1127.46 
                 0.3591 
                 affec 
               
               
                 RS153450 
                 GM2A 
                 5 
                 150676967 
                 
                   0.022 
                 
                 154.47 
                 1127.47 
                 1.6517 
                 young 
               
               
                 RS264834 
                 DOCK2 
                 5 
                 169063385 
                 0.1693 
                 175.34 
                 1148.34 
                 0.7713 
                 affec 
               
               
                 RS2279318 
                 DOCK2 
                 5 
                 169111769 
                 
                   0.02 
                 
                 175.34 
                 1148.34 
                 1.7011 
                 affec 
               
               
                 HCV3138900 
                 DOCK2 
                 5 
                 169129475 
                 
                   0.039 
                 
                 175.34 
                 1148.34 
                 1.4145 
                 young 
               
               
                 HCV1991155 
                 DOCK2 
                 5 
                 169285820 
                 0.0643 
                 175.34 
                 1148.34 
                 1.1918 
                 young 
               
               
                 RS259894 
                 DOCK2 
                 5 
                 169339778 
                 0.2832 
                 175.34 
                 1148.34 
                 0.5479 
                 young 
               
               
                 RS3776754 
                 STK10 
                 5 
                 171553499 
                 0.2856 
                 179.15 
                 1152.15 
                 0.5442 
                 young 
               
               
                 HCV1191601 
                 STK10 
                 5 
                 171570835 
                 0.4158 
                 179.16 
                 1152.16 
                 0.3811 
                 young 
               
               
                 RS2009658 
                 LTA 
                 6 
                 31642549 
                 0.1112 
                 44.91 
                 1200.91 
                 0.9539 
                 affec 
               
               
                 RS1800683 
                 LTA 
                 6 
                 31644375 
                 0.2059 
                 44.91 
                 1200.91 
                 0.6863 
                 affec 
               
               
                 RS2239704 
                 LTA 
                 6 
                 31644445 
                 0.1247 
                 44.91 
                 1200.91 
                 0.9041 
                 affec 
               
               
                 RS2857713 
                 LTA 
                 6 
                 31644860 
                 
                   0.03 
                 
                 44.91 
                 1200.91 
                 1.5258 
                 young 
               
               
                 HCV2451908 
                 LTA 
                 6 
                 31644860 
                 0.1574 
                 44.91 
                 1200.91 
                 0.8030 
                 young 
               
               
                 RS1041981 
                 LTA 
                 6 
                 31645088 
                 0.162 
                 44.91 
                 1200.91 
                 0.7905 
                 affec 
               
               
                 RS3093665 
                 LTA 
                 6 
                 31649695 
                 0.6647 
                 44.91 
                 1200.91 
                 0.1774 
                 old 
               
               
                 HCV2455646 
                 HLA- 
                 6 
                 32480465 
                 
                   0.034 
                 
                 45.50 
                 1201.50 
                 1.4647 
                 young 
               
               
                   
                 DRA 
               
               
                 RS8084 
                 HLA- 
                 6 
                 32482258 
                 0.0982 
                 45.50 
                 1201.50 
                 1.0079 
                 affec 
               
               
                   
                 DRA 
               
               
                 RS3134994 
                 HLA- 
                 6 
                 32684102 
                 
                   0.04 
                 
                 45.56 
                 1201.56 
                 1.3947 
                 affec 
               
               
                   
                 DQB1 
               
               
                 RS2051600 
                 HLA- 
                 6 
                 32756316 
                 
                   0.048 
                 
                 45.79 
                 1201.79 
                 1.3170 
                 affec 
               
               
                   
                 DQA2 
               
               
                 RS5018343 
                 HLA- 
                 6 
                 32757126 
                 
                   0.017 
                 
                 45.79 
                 1201.79 
                 1.7620 
                 old 
               
               
                   
                 DQA2 
               
               
                 RS2395252 
                 HLA- 
                 6 
                 32758327 
                 0.2093 
                 45.79 
                 1201.79 
                 0.6792 
                 old 
               
               
                   
                 DQA2 
               
               
                 RS2213566 
                 HLA- 
                 6 
                 32760040 
                 0.1537 
                 45.80 
                 1201.80 
                 0.8133 
                 old 
               
               
                   
                 DQA2 
               
               
                 RS1042434 
                 HLA- 
                 6 
                 33083392 
                 0.3749 
                 46.84 
                 1202.84 
                 0.4261 
                 young 
               
               
                   
                 DPA1 
               
               
                 RS1042174 
                 HLA- 
                 6 
                 33084513 
                 0.1988 
                 46.84 
                 1202.84 
                 0.7016 
                 old 
               
               
                   
                 DPA1 
               
               
                 RS3135021 
                 HLA- 
                 6 
                 33092445 
                 0.0536 
                 46.87 
                 1202.87 
                 1.2708 
                 affec 
               
               
                   
                 DPA1 
               
               
                 RS1367730 
                 HLA- 
                 6 
                 33105001 
                 0.3394 
                 46.91 
                 1202.91 
                 0.4693 
                 young 
               
               
                   
                 DPA1 
               
               
                 RS1051931 
                 PLA2G7 
                 6 
                 46719779 
                 0.1224 
                 73.13 
                 1229.13 
                 0.9122 
                 old 
               
               
                 RS1805018 
                 PLA2G7 
                 6 
                 46726139 
                 0.0938 
                 73.13 
                 1229.13 
                 1.0278 
                 young 
               
               
                 RS1805017 
                 PLA2G7 
                 6 
                 46731058 
                 
                   0.006 
                 
                 73.13 
                 1229.13 
                 2.2518 
                 old 
               
               
                 HCV2032816 
                 PLA2G7 
                 6 
                 46746128 
                 
                   0.003 
                 
                 73.13 
                 1229.13 
                 2.4815 
                 old 
               
               
                 RS1862008 
                 PLA2G7 
                 6 
                 46757115 
                 
                   0.007 
                 
                 73.13 
                 1229.13 
                 2.1739 
                 affec 
               
               
                 RS1014310 
                 BPAG1 
                 6 
                 56484911 
                 
                   0.029 
                 
                 80.01 
                 1236.01 
                 1.5406 
                 old 
               
               
                 RS2024751 
                 BPAG1 
                 6 
                 56491004 
                 0.0659 
                 80.01 
                 1236.01 
                 1.1811 
                 affec 
               
               
                 RS1024196 
                 BPAG1 
                 6 
                 56554325 
                 0.2547 
                 80.02 
                 1236.02 
                 0.5940 
                 old 
               
               
                 RS2613118 
                 BPAG1 
                 6 
                 56775479 
                 
                   0.042 
                 
                 80.06 
                 1236.06 
                 1.3737 
                 affec 
               
               
                 RS3752581 
                 PLN 
                 6 
                 118915300 
                 
                   0.015 
                 
                 121.97 
                 1277.97 
                 1.8125 
                 young 
               
               
                 6P0325 
                 PLN 
                 6 
                 118915300 
                 
                   0.025 
                 
                 121.97 
                 1277.97 
                 1.6073 
                 young 
               
               
                 RS503031 
                 PLN 
                 6 
                 118922380 
                 0.3777 
                 121.97 
                 1277.97 
                 0.4229 
                 young 
               
               
                 6P0324 
                 PLN 
                 6 
                 118926210 
                 
                   0.027 
                 
                 121.97 
                 1277.97 
                 1.5768 
                 young 
               
               
                 6P0326 
                 PLN 
                 6 
                 118927230 
                 
                   0.046 
                 
                 121.97 
                 1277.97 
                 1.3335 
                 affec 
               
               
                 RS1051429 
                 PLN 
                 6 
                 118927392 
                 
                   1E−04 
                 
                 121.97 
                 1277.97 
                 4.0000 
                 young 
               
               
                 RS1998482 
                 PLN 
                 6 
                 118931682 
                 0.3632 
                 121.97 
                 1277.97 
                 0.4399 
                 affec 
               
               
                 RS3734382 
                 PLN 
                 6 
                 118932531 
                 
                   0.001 
                 
                 121.97 
                 1277.97 
                 2.9586 
                 young 
               
               
                 RS1385681 
                 SMPDL3A 
                 6 
                 123099762 
                 
                   0.033 
                 
                 123.04 
                 1279.04 
                 1.4881 
                 young 
               
               
                 HCV375819 
                 SMPDL3A 
                 6 
                 123103040 
                 0.0761 
                 123.05 
                 1279.05 
                 1.1186 
                 old 
               
               
                 RS869478 
                 SMPDL3A 
                 6 
                 123104550 
                 
                   0.046 
                 
                 123.05 
                 1279.05 
                 1.3344 
                 young 
               
               
                 HCV11639376 
                 SMPDL3A 
                 6 
                 123109735 
                 0.151 
                 123.05 
                 1279.05 
                 0.8210 
                 young 
               
               
                 RS1799971 
                 OPRM1 
                 6 
                 154391788 
                 0.4823 
                 155.08 
                 1311.08 
                 0.3167 
                 affec 
               
               
                 RS524731 
                 OPRM1 
                 6 
                 154406083 
                 0.2537 
                 155.11 
                 1311.11 
                 0.5957 
                 affec 
               
               
                 RS495491 
                 OPRM1 
                 6 
                 154413533 
                 0.3433 
                 155.12 
                 1311.12 
                 0.4643 
                 young 
               
               
                 RS2075572 
                 OPRM1 
                 6 
                 154442995 
                 0.1601 
                 155.17 
                 1311.17 
                 0.7956 
                 affec 
               
               
                 RS609148 
                 OPRM1 
                 6 
                 154462005 
                 
                   0.014 
                 
                 155.17 
                 1311.17 
                 1.8570 
                 affec 
               
               
                 HCV11233252 
                 STEAP 
                 7 
                 22355367 
                 
                   0.026 
                 
                 36.03 
                 1379.03 
                 1.5850 
                 young 
               
               
                 RS199348 
                 GPNMB 
                 7 
                 23035370 
                 
                   0.023 
                 
                 37.81 
                 1380.81 
                 1.6383 
                 affec 
               
               
                 HCV963057 
                 GPNMB 
                 7 
                 23036018 
                 
                   0.029 
                 
                 37.81 
                 1380.81 
                 1.5452 
                 old 
               
               
                 HCV3148292 
                 GPNMB 
                 7 
                 23038805 
                 
                   0.019 
                 
                 37.81 
                 1380.81 
                 1.7122 
                 old 
               
               
                 RS199354 
                 GPNMB 
                 7 
                 23038844 
                 0.2886 
                 37.81 
                 1380.81 
                 0.5397 
                 old 
               
               
                 RS2268748 
                 GPNMB 
                 7 
                 23055443 
                 0.3093 
                 37.85 
                 1380.85 
                 0.5096 
                 affec 
               
               
                 RS5574 
                 NPY 
                 7 
                 24071405 
                 
                   0.023 
                 
                 38.94 
                 1381.94 
                 1.6440 
                 young 
               
               
                 RS5573 
                 NPY 
                 7 
                 24325077 
                 
                   0.015 
                 
                 39.02 
                 1382.02 
                 1.8327 
                 young 
               
               
                 RS1554494 
                 UPP1 
                 7 
                 47868969 
                 
                   0.021 
                 
                 69.82 
                 1412.82 
                 1.6882 
                 young 
               
               
                 HCV406653 
                 UPP1 
                 7 
                 47872326 
                 
                   0.027 
                 
                 69.82 
                 1412.82 
                 1.5751 
                 young 
               
               
                 RS1178970 
                 FKBP6 
                 7 
                 71817507 
                 0.2217 
                 84.52 
                 1427.52 
                 0.6542 
                 old 
               
               
                 RS757941 
                 FKBP6 
                 7 
                 71823497 
                 
                   0.015 
                 
                 84.52 
                 1427.52 
                 1.8268 
                 old 
               
               
                 RS374890 
                 FKBP6 
                 7 
                 71852334 
                 0.1216 
                 84.52 
                 1427.52 
                 0.9151 
                 old 
               
               
                 RS1178968 
                 FKBP6 
                 7 
                 72179548 
                 0.3068 
                 87.08 
                 1430.08 
                 0.5131 
                 old 
               
               
                 RS1045642 
                 ABCB1 
                 7 
                 86099488 
                 0.0746 
                 98.27 
                 1441.27 
                 1.1273 
                 affec 
               
               
                 RS1128503 
                 ABCB1 
                 7 
                 86791630 
                 0.2757 
                 98.44 
                 1441.44 
                 0.5596 
                 affec 
               
               
                 HCV2614970 
                 ABCB1 
                 7 
                 86841469 
                 0.0693 
                 98.44 
                 1441.44 
                 1.1593 
                 old 
               
               
                 RS2214102 
                 ABCB1 
                 7 
                 86841530 
                 0.1155 
                 98.44 
                 1441.44 
                 0.9374 
                 old 
               
               
                 RS2158746 
                 STEAP 
                 7 
                 89396798 
                 0.0928 
                 100.23 
                 1443.23 
                 1.0325 
                 old 
               
               
                 RS39283 
                 STEAP 
                 7 
                 89400835 
                 0.3351 
                 100.24 
                 1443.24 
                 0.4748 
                 affec 
               
               
                 RS39286 
                 STEAP 
                 7 
                 89404279 
                 0.1618 
                 100.24 
                 1443.24 
                 0.7910 
                 old 
               
               
                 RS2286254 
                 STEAP 
                 7 
                 89405670 
                 0.5045 
                 100.24 
                 1443.24 
                 0.2971 
                 affec 
               
               
                 RS437831 
                 FABP5 
                 8 
                 82240584 
                 0.5983 
                 97.93 
                 1610.43 
                 0.2231 
                 young 
               
               
                 RS202275 
                 FABP5 
                 8 
                 82250480 
                 0.1955 
                 97.97 
                 1610.47 
                 0.7089 
                 young 
               
               
                 RS202281 
                 FABP5 
                 8 
                 82253950 
                 0.0997 
                 97.99 
                 1610.49 
                 1.0013 
                 young 
               
               
                 RS2252807 
                 SLA 
                 8 
                 134019501 
                 0.0719 
                 147.49 
                 1659.99 
                 1.1433 
                 affec 
               
               
                 HCV1190217 
                 ANKRD15 
                 9 
                 522762 
                 0.3159 
                 0.00 
                 1684.00 
                 0.5005 
                 affec 
               
               
                 RS2641989 
                 ANKRD15 
                 9 
                 542379 
                 
                   0.047 
                 
                 0.00 
                 1684.00 
                 1.3242 
                 old 
               
               
                 HCV1182387 
                 ADFP 
                 9 
                 19105720 
                 0.2863 
                 33.60 
                 1717.60 
                 0.5432 
                 young 
               
               
                 RS3824369 
                 ADFP 
                 9 
                 19116565 
                 0.0508 
                 33.62 
                 1717.62 
                 1.2941 
                 affec 
               
               
                 RS1969980 
                 GCNT1 
                 9 
                 74573227 
                 0.4972 
                 73.03 
                 1757.03 
                 0.3035 
                 young 
               
               
                 RS1057406 
                 GCNT1 
                 9 
                 74575448 
                 0.1741 
                 73.03 
                 1757.03 
                 0.7592 
                 young 
               
               
                 RS707739 
                 GCNT1 
                 9 
                 74576022 
                 0.3716 
                 73.03 
                 1757.03 
                 0.4299 
                 affec 
               
               
                 HCV11763416 
                 GCNT1 
                 9 
                 74582459 
                 0.1179 
                 73.03 
                 1757.03 
                 0.9285 
                 affec 
               
               
                 HCV2704852 
                 CTSL 
                 9 
                 85790518 
                 
                   0.047 
                 
                 92.00 
                 1776.00 
                 1.3242 
                 old 
               
               
                 RS2274611 
                 CTSL 
                 9 
                 85799794 
                 0.101 
                 92.02 
                 1776.02 
                 0.9957 
                 affec 
               
               
                 RS2378757 
                 CTSL 
                 9 
                 85800899 
                 0.1833 
                 92.03 
                 1776.03 
                 0.7368 
                 affec 
               
               
                 RS3128510 
                 CTSL 
                 9 
                 85802727 
                 0.1418 
                 92.03 
                 1776.03 
                 0.8483 
                 affec 
               
               
                 RS1027268 
                 ROR2 
                 9 
                 89712759 
                 0.4149 
                 99.32 
                 1783.32 
                 0.3821 
                 old 
               
               
                 HCV11889939 
                 ROR2 
                 9 
                 89823450 
                 0.0676 
                 99.45 
                 1783.45 
                 1.1701 
                 old 
               
               
                 RS4744098 
                 ROR2 
                 9 
                 89885691 
                 0.1741 
                 99.51 
                 1783.51 
                 0.7592 
                 affec 
               
               
                 RS1881385 
                 ROR2 
                 9 
                 89938190 
                 0.1356 
                 99.57 
                 1783.57 
                 0.8677 
                 affec 
               
               
                 HCV203542 
                 ROR2 
                 9 
                 89993111 
                 
                   0.017 
                 
                 99.62 
                 1783.62 
                 1.7670 
                 young 
               
               
                 HCV1435528 
                 FBP1 
                 9 
                 92725520 
                 0.5689 
                 102.25 
                 1786.25 
                 0.2450 
                 old 
               
               
                 HCV11380659 
                 ALOX5 
                 10 
                 45175490 
                 0.5012 
                 66.97 
                 1896.97 
                 0.3000 
                 young 
               
               
                 RS2115819 
                 ALOX5 
                 10 
                 45185095 
                 0.1601 
                 66.98 
                 1896.98 
                 0.7956 
                 young 
               
               
                 RS892691 
                 ALOX5 
                 10 
                 45201098 
                 0.5357 
                 66.99 
                 1896.99 
                 0.2711 
                 young 
               
               
                 RS3740107 
                 ALOX5 
                 10 
                 45207776 
                 0.1431 
                 66.99 
                 1896.99 
                 0.8444 
                 young 
               
               
                 RS2242332 
                 ALOX5 
                 10 
                 45222245 
                 0.1535 
                 66.99 
                 1896.99 
                 0.8139 
                 young 
               
               
                 RS2255174 
                 SLIT1 
                 10 
                 98480960 
                 0.319 
                 118.58 
                 1948.58 
                 0.4962 
                 affec 
               
               
                 RS2784920 
                 SLIT1 
                 10 
                 98578215 
                 0.3611 
                 118.86 
                 1948.86 
                 0.4424 
                 affec 
               
               
                 RS1565495 
                 SLIT1 
                 10 
                 98603394 
                 0.567 
                 118.93 
                 1948.93 
                 0.2464 
                 old 
               
               
                 RS2071616 
                 FGFR2 
                 10 
                 122944382 
                 0.4336 
                 142.78 
                 1972.78 
                 0.3629 
                 affec 
               
               
                 RS1047100 
                 FGFR2 
                 10 
                 122962745 
                 0.1942 
                 142.82 
                 1972.82 
                 0.7118 
                 young 
               
               
                 HCV8899692 
                 FGFR2 
                 10 
                 122962745 
                 0.319 
                 142.82 
                 1972.82 
                 0.4962 
                 affec 
               
               
                 RS1078806 
                 FGFR2 
                 10 
                 123003562 
                 0.2664 
                 142.93 
                 1972.93 
                 0.5745 
                 young 
               
               
                 HCV438264 
                 RPLP2 
                 11 
                 803830 
                 
                   0.043 
                 
                 0.00 
                 2000.00 
                 1.3655 
                 affec 
               
               
                 RS4131364 
                 TTS-2.2 
                 11 
                 803830 
                 
                   0.021 
                 
                 0.00 
                 2000.00 
                 1.6696 
                 affec 
               
               
                 RS1135628 
                 TTS-2.2 
                 11 
                 815456 
                 0.1877 
                 0.00 
                 2000.00 
                 0.7265 
                 young 
               
               
                 HCV113313 
                 CD151 
                 11 
                 816753 
                 0.1094 
                 0.00 
                 2000.00 
                 0.9610 
                 affec 
               
               
                 RS1138714 
                 TTS-2.2 
                 11 
                 816753 
                 0.1086 
                 0.00 
                 2000.00 
                 0.9642 
                 affec 
               
               
                 RS4075289 
                 TTS-2.2 
                 11 
                 822313 
                 0.2992 
                 0.00 
                 2000.00 
                 0.5240 
                 old 
               
               
                 RS2292962 
                 CTSD 
                 11 
                 1742630 
                 0.1193 
                 2.44 
                 2002.44 
                 0.9234 
                 affec 
               
               
                 RS1317356 
                 CTSD 
                 11 
                 1743447 
                 0.1309 
                 2.44 
                 2002.44 
                 0.8831 
                 old 
               
               
                 RS17571 
                 CTSD 
                 11 
                 1746903 
                 
                   0.034 
                 
                 2.44 
                 2002.44 
                 1.4750 
                 old 
               
               
                 RS830083 
                 ACP2 
                 11 
                 47218360 
                 0.2321 
                 58.40 
                 2058.40 
                 0.6343 
                 affec 
               
               
                 RS11988 
                 ACP2 
                 11 
                 47225569 
                 0.2032 
                 58.40 
                 2058.40 
                 0.6921 
                 affec 
               
               
                 RS2242261 
                 ACP2 
                 11 
                 47231117 
                 0.2201 
                 58.40 
                 2058.40 
                 0.6574 
                 affec 
               
               
                 HCV1301047 
                 ACP2 
                 11 
                 47234245 
                 0.2999 
                 58.40 
                 2058.40 
                 0.5230 
                 affec 
               
               
                 RS3758673 
                 NR1H3 
                 11 
                 47243226 
                 0.1476 
                 58.40 
                 2058.40 
                 0.8309 
                 old 
               
               
                 RS2279238 
                 NR1H3 
                 11 
                 47246333 
                 0.4009 
                 58.40 
                 2058.40 
                 0.3970 
                 affec 
               
               
                 RS1449627 
                 NR1H3 
                 11 
                 47255293 
                 0.3559 
                 58.40 
                 2058.40 
                 0.4487 
                 young 
               
               
                 RS2291119 
                 NR1H3 
                 11 
                 47262510 
                 0.0758 
                 58.40 
                 2058.40 
                 1.1203 
                 affec 
               
               
                 RS326214 
                 NR1H3 
                 11 
                 47262669 
                 0.3146 
                 58.40 
                 2058.40 
                 0.5022 
                 old 
               
               
                 HCV25595878 
                 TCIRG1 
                 11 
                 64676766 
                 0.1957 
                 66.50 
                 2066.50 
                 0.7084 
                 affec 
               
               
                 RS906713 
                 TCIRG1 
                 11 
                 67589290 
                 0.0679 
                 67.48 
                 2067.48 
                 1.1681 
                 young 
               
               
                 RS2075609 
                 TCIRG1 
                 11 
                 67592296 
                 
                   0.021 
                 
                 67.48 
                 2067.48 
                 1.6861 
                 old 
               
               
                 RS11481 
                 TCIRG1 
                 11 
                 67595695 
                 0.2304 
                 67.48 
                 2067.48 
                 0.6375 
                 old 
               
               
                 RS2851069 
                 SLC21A9 
                 11 
                 74588664 
                 0.6426 
                 77.78 
                 2077.78 
                 0.1921 
                 old 
               
               
                 HCV1786352 
                 SLC21A9 
                 11 
                 74601797 
                 0.4833 
                 77.78 
                 2077.78 
                 0.3158 
                 affec 
               
               
                 RS2851109 
                 SLC21A9 
                 11 
                 74604384 
                 0.555 
                 77.78 
                 2077.78 
                 0.2557 
                 affec 
               
               
                 RS609887 
                 MMP7 
                 11 
                 101922284 
                 0.0613 
                 98.98 
                 2098.98 
                 1.2125 
                 young 
               
               
                 11P0321 
                 MMP7 
                 11 
                 101929004 
                 0.1658 
                 98.98 
                 2098.98 
                 0.7804 
                 old 
               
               
                 HCV12088722 
                 MMP7 
                 11 
                 101929142 
                 
                   0.009 
                 
                 98.98 
                 2098.98 
                 2.0362 
                 affec 
               
               
                 RS1996352 
                 MMP7 
                 11 
                 101933964 
                 0.0932 
                 98.98 
                 2098.98 
                 1.0306 
                 affec 
               
               
                 HCV3210838 
                 MMP7 
                 11 
                 101936310 
                 
                   0.003 
                 
                 98.98 
                 2098.98 
                 2.5686 
                 affec 
               
               
                 RS1943779 
                 MMP7 
                 11 
                 101944908 
                 0.2188 
                 98.98 
                 2098.98 
                 0.6600 
                 young 
               
               
                 RS674546 
                 MMP12 
                 11 
                 102268356 
                 
                   0.049 
                 
                 99.11 
                 2099.11 
                 1.3098 
                 affec 
               
               
                 RS505770 
                 MMP12 
                 11 
                 102271927 
                 0.1518 
                 99.11 
                 2099.11 
                 0.8187 
                 affec 
               
               
                 HCV785907 
                 MMP12 
                 11 
                 102274359 
                 0.2482 
                 99.11 
                 2099.11 
                 0.6052 
                 young 
               
               
                 RS2276109 
                 MMP12 
                 11 
                 102283508 
                 0.1997 
                 99.12 
                 2099.12 
                 0.6996 
                 young 
               
               
                 RS1277718 
                 MMP12 
                 11 
                 102285268 
                 0.1288 
                 99.12 
                 2099.12 
                 0.8901 
                 young 
               
               
                 RS660407 
                 FLI1 
                 11 
                 128175388 
                 
                   0.032 
                 
                 131.26 
                 2131.26 
                 1.5003 
                 old 
               
               
                 RS497714 
                 FLI1 
                 11 
                 128181205 
                 0.0531 
                 131.26 
                 2131.26 
                 1.2749 
                 old 
               
               
                 RS526091 
                 FLI1 
                 11 
                 128188604 
                 0.231 
                 131.26 
                 2131.26 
                 0.6364 
                 affec 
               
               
                 RS656972 
                 FLI1 
                 11 
                 128198398 
                 0.2855 
                 131.27 
                 2131.27 
                 0.5444 
                 affec 
               
               
                 RS687326 
                 FLI1 
                 11 
                 128210233 
                 0.1014 
                 131.47 
                 2131.47 
                 0.9940 
                 young 
               
               
                 RS2301262 
                 PTPN6 
                 12 
                 6926121 
                 0.1455 
                 16.22 
                 2157.22 
                 0.8371 
                 old 
               
               
                 HCV3266450 
                 PTPN6 
                 12 
                 6927395 
                 
                   0.038 
                 
                 16.23 
                 2157.23 
                 1.4214 
                 affec 
               
               
                 RS7978658 
                 PTPN6 
                 12 
                 6928231 
                 
                   0.039 
                 
                 16.23 
                 2157.23 
                 1.4101 
                 affec 
               
               
                 RS7966756 
                 PTPN6 
                 12 
                 6932652 
                 0.2119 
                 16.25 
                 2157.25 
                 0.6739 
                 affec 
               
               
                 RS2110072 
                 PTPN6 
                 12 
                 6935896 
                 0.1585 
                 16.26 
                 2157.26 
                 0.8000 
                 old 
               
               
                 RS253147 
                 CLECSF2 
                 12 
                 9906349 
                 0.2628 
                 20.27 
                 2161.27 
                 0.5804 
                 affec 
               
               
                 RS1050286 
                 OLR1 
                 12 
                 10202830 
                 0.0555 
                 20.27 
                 2161.27 
                 1.2557 
                 young 
               
               
                 12P0322 
                 OLR1 
                 12 
                 10203915 
                 0.0737 
                 20.27 
                 2161.27 
                 1.1325 
                 affec 
               
               
                 HCV3130874 
                 OLR1 
                 12 
                 10204532 
                 0.0635 
                 20.27 
                 2161.27 
                 1.1972 
                 affec 
               
               
                 RS3736232 
                 OLR1 
                 12 
                 10204625 
                 0.0819 
                 20.27 
                 2161.27 
                 1.0867 
                 affec 
               
               
                 RS3741860 
                 OLR1 
                 12 
                 10211711 
                 0.0952 
                 20.27 
                 2161.27 
                 1.0214 
                 affec 
               
               
                 RS2742113 
                 OLR1 
                 12 
                 10214149 
                 0.063 
                 20.27 
                 2161.27 
                 1.2007 
                 affec 
               
               
                 RS1548836 
                 RAI3 
                 12 
                 12945501 
                 0.2949 
                 29.49 
                 2170.49 
                 0.5303 
                 young 
               
               
                 RS2075288 
                 RAI3 
                 12 
                 12952561 
                 0.4566 
                 29.55 
                 2170.55 
                 0.3405 
                 young 
               
               
                 RS1061047 
                 RAI3 
                 12 
                 12957487 
                 0.1835 
                 29.59 
                 2170.59 
                 0.7364 
                 young 
               
               
                 RS1800801 
                 MGP 
                 12 
                 14930055 
                 0.2413 
                 31.67 
                 2172.67 
                 0.6174 
                 old 
               
               
                 RS3741552 
                 ITPR2 
                 12 
                 26624254 
                 0.1641 
                 46.84 
                 2187.84 
                 0.7849 
                 affec 
               
               
                 RS2230372 
                 ITPR2 
                 12 
                 26676117 
                 0.3387 
                 46.95 
                 2187.95 
                 0.4702 
                 old 
               
               
                 RS2291264 
                 ITPR2 
                 12 
                 26702044 
                 0.1558 
                 47.01 
                 2188.01 
                 0.8074 
                 affec 
               
               
                 RS1900941 
                 ITPR2 
                 12 
                 26759589 
                 0.0604 
                 47.13 
                 2188.13 
                 1.2190 
                 affec 
               
               
                 RS1449568 
                 ITPR2 
                 12 
                 26802972 
                 
                   0.03 
                 
                 47.23 
                 2188.23 
                 1.5229 
                 affec 
               
               
                 RS2016107 
                 TUBA3 
                 12 
                 47863524 
                 0.1658 
                 64.43 
                 2205.43 
                 0.7804 
                 old 
               
               
                 RS6580704 
                 TUBA3 
                 12 
                 47866447 
                 0.2749 
                 64.43 
                 2205.43 
                 0.5608 
                 old 
               
               
                 RS1039225 
                 TUBA3 
                 12 
                 47868959 
                 0.0957 
                 64.43 
                 2205.43 
                 1.0191 
                 young 
               
               
                 RS1874908 
                 TUBA3 
                 12 
                 47870297 
                 0.3594 
                 64.43 
                 2205.43 
                 0.4444 
                 old 
               
               
                 HCV48424 
                 PTPRR 
                 12 
                 69334002 
                 0.6934 
                 82.12 
                 2223.12 
                 0.1590 
                 affec 
               
               
                 RS2137537 
                 PTPRR 
                 12 
                 69399354 
                 
                   0.017 
                 
                 82.12 
                 2223.12 
                 1.7773 
                 young 
               
               
                 RS972769 
                 PTPRR 
                 12 
                 69419738 
                 0.125 
                 82.14 
                 2223.14 
                 0.9031 
                 affec 
               
               
                 HCV155408 
                 PTPRR 
                 12 
                 69525275 
                 0.1261 
                 82.33 
                 2223.33 
                 0.8993 
                 affec 
               
               
                 HCV93800 
                 PTPRR 
                 12 
                 69570924 
                 
                   0.042 
                 
                 82.41 
                 2223.41 
                 1.3809 
                 young 
               
               
                 RS2300588 
                 LUM 
                 12 
                 90002365 
                 0.1377 
                 96.09 
                 2237.09 
                 0.8611 
                 young 
               
               
                 RS2230754 
                 PLXNC1 
                 12 
                 93045974 
                 0.3762 
                 97.16 
                 2238.16 
                 0.4246 
                 affec 
               
               
                 RS3858609 
                 PLXNC1 
                 12 
                 93067143 
                 0.2971 
                 97.16 
                 2238.16 
                 0.5271 
                 old 
               
               
                 RS2305971 
                 PLXNC1 
                 12 
                 93105768 
                 
                   0.02 
                 
                 97.16 
                 2238.16 
                 1.7011 
                 young 
               
               
                 RS2242498 
                 PLXNC1 
                 12 
                 93152063 
                 0.3119 
                 97.30 
                 2238.30 
                 0.5060 
                 young 
               
               
                 RS1681866 
                 PLXNC1 
                 12 
                 93178913 
                 0.2017 
                 97.41 
                 2238.41 
                 0.6953 
                 old 
               
               
                 RS25642 
                   
                 12 
                 120071870 
                 0.2587 
                 139.61 
                 2280.61 
                 0.5872 
                 young 
               
               
                 RS25643 
                 P2RX4 
                 12 
                 120072740 
                 0.146 
                 139.61 
                 2280.61 
                 0.8356 
                 young 
               
               
                 RS25644 
                 CAMKK2 
                 12 
                 120078599 
                 0.0763 
                 139.61 
                 2280.61 
                 1.1175 
                 young 
               
               
                 RS2071272 
                 P2RX4 
                 12 
                 120082745 
                 0.1241 
                 139.61 
                 2280.61 
                 0.9062 
                 young 
               
               
                 RS6750 
                 OSF-2 
                 13 
                 35934832 
                 0.3582 
                 31.37 
                 2342.37 
                 0.4459 
                 old 
               
               
                 HCV227836 
                 OSF-2 
                 13 
                 35944998 
                 0.2274 
                 31.39 
                 2342.39 
                 0.6432 
                 young 
               
               
                 HCV11170344 
                 OSF-2 
                 13 
                 35952189 
                 0.2378 
                 31.41 
                 2342.41 
                 0.6238 
                 young 
               
               
                 HCV1909050 
                 OSF-2 
                 13 
                 35952905 
                 0.5775 
                 31.41 
                 2342.41 
                 0.2384 
                 old 
               
               
                 HCV1909043 
                 OSF-2 
                 13 
                 35961093 
                 0.3062 
                 31.43 
                 2342.43 
                 0.5140 
                 old 
               
               
                 HCV1909039 
                 OSF-2 
                 13 
                 35969741 
                 0.2654 
                 31.45 
                 2342.45 
                 0.5761 
                 young 
               
               
                 RS1890139 
                 PCCA 
                 13 
                 98480093 
                 0.3662 
                 81.06 
                 2392.06 
                 0.4363 
                 young 
               
               
                 HCV1823453 
                 PCCA 
                 13 
                 98526614 
                 
                   0.018 
                 
                 81.29 
                 2392.29 
                 1.7423 
                 young 
               
               
                 HCV2747127 
                 PCCA 
                 13 
                 98616632 
                 0.0531 
                 81.64 
                 2392.64 
                 1.2749 
                 old 
               
               
                 RS1296332 
                 PCCA 
                 13 
                 98811747 
                 0.2807 
                 81.64 
                 2392.64 
                 0.5518 
                 affec 
               
               
                 HCV2786590 
                 RTN1 
                 14 
                 58099812 
                 0.2634 
                 66.81 
                 2486.81 
                 0.5794 
                 affec 
               
               
                 HCV1964266 
                 RTN1 
                 14 
                 58169316 
                 0.1343 
                 66.81 
                 2486.81 
                 0.8719 
                 affec 
               
               
                 HCV1964289 
                 RTN1 
                 14 
                 58199104 
                 0.116 
                 66.81 
                 2486.81 
                 0.9355 
                 affec 
               
               
                 HCV2141342 
                 RTN1 
                 14 
                 58293242 
                 0.0786 
                 66.81 
                 2486.81 
                 1.1046 
                 young 
               
               
                 RS1951795 
                 HIF1A 
                 14 
                 60161467 
                 0.1871 
                 67.51 
                 2487.51 
                 0.7279 
                 young 
               
               
                 RS3783752 
                 HIF1A 
                 14 
                 60175733 
                 
                   0.007 
                 
                 67.52 
                 2487.52 
                 2.1612 
                 affec 
               
               
                 RS2301111 
                 HIF1A 
                 14 
                 60190242 
                 0.3087 
                 67.54 
                 2487.54 
                 0.5105 
                 young 
               
               
                 RS2301113 
                 HIF1A 
                 14 
                 60196589 
                 0.1522 
                 67.54 
                 2487.54 
                 0.8176 
                 affec 
               
               
                 RS2057482 
                 HIF1A 
                 14 
                 60203889 
                 0.2456 
                 67.55 
                 2487.55 
                 0.6098 
                 young 
               
               
                 RS875395 
                 ITPK1 
                 14 
                 91392134 
                 
                   0.031 
                 
                 107.41 
                 2527.41 
                 1.5072 
                 young 
               
               
                 HCV1259613 
                 ITPK1 
                 14 
                 91399119 
                 
                   0.039 
                 
                 107.43 
                 2527.43 
                 1.4067 
                 old 
               
               
                 RS2295394 
                 ITPK1 
                 14 
                 91402784 
                 0.4938 
                 107.44 
                 2527.44 
                 0.3064 
                 young 
               
               
                 RS2402226 
                 ITPK1 
                 14 
                 91409576 
                 
                   0.013 
                 
                 107.45 
                 2527.45 
                 1.8729 
                 old 
               
               
                 RS1614269 
                 ITPK1 
                 14 
                 91493546 
                 0.1583 
                 107.63 
                 2527.63 
                 0.8005 
                 old 
               
               
                 RS1740595 
                 ITPK1 
                 14 
                 91502571 
                 0.1124 
                 107.65 
                 2527.65 
                 0.9492 
                 old 
               
               
                 RS4905043 
                 ITPK1 
                 14 
                 91540050 
                 0.0743 
                 107.73 
                 2527.73 
                 1.1290 
                 affec 
               
               
                 HCV1258994 
                 ITPK1 
                 14 
                 91544259 
                 0.659 
                 107.74 
                 2527.74 
                 0.1811 
                 affec 
               
               
                 HCV1882714 
                 C14ORF132 
                 14 
                 94541644 
                 0.2806 
                 114.81 
                 2534.81 
                 0.5519 
                 affec 
               
               
                 HCV1882697 
                 C14ORF132 
                 14 
                 94549500 
                 0.1478 
                 114.81 
                 2534.81 
                 0.8303 
                 young 
               
               
                 HCV9706786 
                 PP9099 
                 15 
                 43808547 
                 0.2693 
                 42.89 
                 2583.89 
                 0.5698 
                 affec 
               
               
                 HCV1977407 
                 PP9099 
                 15 
                 62851357 
                 0.3227 
                 60.14 
                 2601.14 
                 0.4912 
                 young 
               
               
                 HCV497654 
                 PP9099 
                 15 
                 62869949 
                 
                   0.046 
                 
                 60.15 
                 2601.15 
                 1.3420 
                 young 
               
               
                 HGV497653 
                 PP9099 
                 15 
                 62870401 
                 0.4805 
                 60.15 
                 2601.15 
                 0.3183 
                 young 
               
               
                 RS293379 
                 ABHD2 
                 15 
                 87363708 
                 0.3178 
                 85.64 
                 2626.64 
                 0.4978 
                 affec 
               
               
                 HCV1597898 
                 ABHD2 
                 15 
                 87381022 
                 0.3416 
                 85.64 
                 2626.64 
                 0.4665 
                 affec 
               
               
                 RS4327024 
                 ABHD2 
                 15 
                 87430443 
                 0.4509 
                 85.64 
                 2626.64 
                 0.3459 
                 young 
               
               
                 RS1005398 
                 ABHD2 
                 15 
                 87449143 
                 
                   0.023 
                 
                 85.64 
                 2626.64 
                 1.6345 
                 old 
               
               
                 RS2239288 
                 ABHD2 
                 15 
                 87461115 
                 0.4109 
                 85.64 
                 2626.64 
                 0.3863 
                 old 
               
               
                 RS10584 
                 ANPEP 
                 15 
                 88058319 
                 
                   0.026 
                 
                 85.64 
                 2626.64 
                 1.5850 
                 affec 
               
               
                 RS1992250 
                 ANPEP 
                 15 
                 88063748 
                 
                   0.014 
                 
                 85.64 
                 2626.64 
                 1.8508 
                 affec 
               
               
                 RS7168793 
                 ANPEP 
                 15 
                 88064008 
                 
                   0.028 
                 
                 85.64 
                 2626.64 
                 1.5575 
                 affec 
               
               
                 RS1439119 
                 ANPEP 
                 15 
                 88068014 
                 
                   0.049 
                 
                 85.64 
                 2626.64 
                 1.3089 
                 affec 
               
               
                 HCV1576494 
                 CIB1 
                 15 
                 88516119 
                 0.2975 
                 85.64 
                 2626.64 
                 0.5265 
                 affec 
               
               
                 HCV12104474 
                 CIB1 
                 15 
                 88524613 
                 0.3159 
                 85.64 
                 2626.64 
                 0.5005 
                 affec 
               
               
                 RS1105702 
                 CIB1 
                 15 
                 88525621 
                 0.5284 
                 85.64 
                 2626.64 
                 0.2770 
                 young 
               
               
                 RS2048707 
                 CIB1 
                 15 
                 88531352 
                 0.2061 
                 85.65 
                 2626.65 
                 0.6859 
                 affec 
               
               
                 HCV1576445 
                 CIB1 
                 15 
                 88538275 
                 0.1703 
                 85.69 
                 2626.69 
                 0.7688 
                 young 
               
               
                 RS4378630 
                 ITGAX 
                 16 
                 31406512 
                 0.1847 
                 57.79 
                 2712.79 
                 0.7335 
                 old 
               
               
                 RS4264407 
                 ITGAX 
                 16 
                 31407253 
                 0.0903 
                 57.79 
                 2712.79 
                 1.0443 
                 affec 
               
               
                 RS2070896 
                 ITGAX 
                 16 
                 31420614 
                 0.1255 
                 57.79 
                 2712.79 
                 0.9014 
                 affec 
               
               
                 RS2929 
                 ITGAX 
                 16 
                 31429368 
                 0.3302 
                 57.80 
                 2712.80 
                 0.4812 
                 old 
               
               
                 RS1140195 
                 ITGAX 
                 16 
                 31430239 
                 0.1047 
                 57.80 
                 2712.80 
                 0.9801 
                 old 
               
               
                 RS1030868 
                 MMP2 
                 16 
                 55295369 
                 0.3025 
                 73.77 
                 2728.77 
                 0.5193 
                 old 
               
               
                 RS1053605 
                 MMP2 
                 16 
                 55298209 
                 0.2501 
                 73.78 
                 2728.78 
                 0.6019 
                 old 
               
               
                 RS243849 
                 MMP2 
                 16 
                 55302307 
                 0.2651 
                 73.80 
                 2728.80 
                 0.5766 
                 affec 
               
               
                 RS2287076 
                 MMP2 
                 16 
                 55311060 
                 0.3748 
                 73.84 
                 2728.84 
                 0.4262 
                 young 
               
               
                 RS7201 
                 MMP2 
                 16 
                 55318216 
                 0.7635 
                 73.87 
                 2728.87 
                 0.1172 
                 affec 
               
               
                 RS3180279 
                 CYBA 
                 16 
                 88454958 
                 0.1388 
                 131.44 
                 2786.44 
                 0.8576 
                 old 
               
               
                 RS4987131 
                 CYBA 
                 16 
                 88457338 
                 0.467 
                 131.44 
                 2786.44 
                 0.3307 
                 old 
               
               
                 RS3812948 
                 CYBA 
                 16 
                 88460659 
                 0.3852 
                 131.45 
                 2786.45 
                 0.4143 
                 old 
               
               
                 RS3817655 
                 CCL5 
                 17 
                 34345191 
                 0.2133 
                 57.76 
                 2839.26 
                 0.6710 
                 old 
               
               
                 RS2107538 
                 CCL5 
                 17 
                 34353330 
                 0.2404 
                 57.77 
                 2839.27 
                 0.6191 
                 old 
               
               
                 RS1634481 
                 CCL3 
                 17 
                 34551225 
                 0.2031 
                 57.91 
                 2839.41 
                 0.6923 
                 old 
               
               
                 RS1719134 
                 CCL3 
                 17 
                 34562496 
                 0.132 
                 57.92 
                 2839.42 
                 0.8794 
                 old 
               
               
                 RS4432296 
                 CNP 
                 17 
                 40491972 
                 0.4999 
                 62.01 
                 2843.51 
                 0.3011 
                 old 
               
               
                 HCV11618196 
                 CNP 
                 17 
                 40496994 
                 0.1954 
                 62.01 
                 2843.51 
                 0.7091 
                 old 
               
               
                 RS2229931 
                 CNP 
                 17 
                 40498936 
                 0.2762 
                 62.01 
                 2843.51 
                 0.5588 
                 young 
               
               
                 RS2070106 
                 CNP 
                 17 
                 40499029 
                 0.4811 
                 62.01 
                 2843.51 
                 0.3178 
                 affec 
               
               
                 HCV437993 
                 CNP 
                 17 
                 40499352 
                 0.0818 
                 62.01 
                 2843.51 
                 1.0872 
                 old 
               
               
                 RS2272087 
                 STAT5A 
                 17 
                 40832727 
                 0.2716 
                 63.09 
                 2844.59 
                 0.5661 
                 young 
               
               
                 RS1135669 
                 STAT5A 
                 17 
                 40832902 
                 0.3946 
                 63.09 
                 2844.59 
                 0.4038 
                 young 
               
               
                 RS3198502 
                 STAT5A 
                 17 
                 40836159 
                 0.1796 
                 63.09 
                 2844.59 
                 0.7457 
                 old 
               
               
                 HCV2548250 
                 GRN 
                 17 
                 42898428 
                 
                   0.029 
                 
                 63.70 
                 2845.20 
                 1.5421 
                 young 
               
               
                 RS3785817 
                 GRN 
                 17 
                 42898830 
                 0.1495 
                 63.70 
                 2845.20 
                 0.8254 
                 affec 
               
               
                 RS3815057 
                 GRN 
                 17 
                 42902795 
                 
                   0.024 
                 
                 63.71 
                 2845.21 
                 1.6144 
                 old 
               
               
                 RS25647 
                 GRN 
                 17 
                 42905004 
                 0.503 
                 63.71 
                 2845.21 
                 0.2984 
                 affec 
               
               
                 RS5848 
                 GRN 
                 17 
                 42905409 
                 0.2219 
                 63.71 
                 2845.21 
                 0.6538 
                 affec 
               
               
                 HCV9267947 
                 FMNL1 
                 17 
                 43791782 
                 
                   0.036 
                 
                 64.86 
                 2846.36 
                 1.4425 
                 old 
               
               
                 RS1801353 
                 FMNL1 
                 17 
                 43795192 
                 
                   0.05 
                 
                 64.87 
                 2846.37 
                 1.3019 
                 old 
               
               
                 HCV9267944 
                 FLJ25414 
                 17 
                 43808547 
                 0.0635 
                 64.88 
                 2846.38 
                 1.1972 
                 old 
               
               
                 RS1384367 
                 PSCD1 
                 17 
                 77326880 
                 0.2378 
                 109.57 
                 2891.07 
                 0.6238 
                 old 
               
               
                 RS1871935 
                 PSCD1 
                 17 
                 77361268 
                 0.1061 
                 109.76 
                 2891.26 
                 0.9743 
                 young 
               
               
                 HCV12126963 
                 PSCD1 
                 17 
                 77370761 
                 0.0904 
                 109.81 
                 2891.31 
                 1.0438 
                 old 
               
               
                 RS2276195 
                 TCF4 
                 18 
                 51045496 
                 0.1176 
                 77.12 
                 2985.12 
                 0.9296 
                 old 
               
               
                 RS1261076 
                 TCF4 
                 18 
                 51057313 
                 0.1318 
                 77.13 
                 2985.13 
                 0.8801 
                 old 
               
               
                 HCV11452698 
                 TCF4 
                 18 
                 51067704 
                 0.133 
                 77.14 
                 2985.14 
                 0.8761 
                 young 
               
               
                 RS1440476 
                 TCF4 
                 18 
                 51189053 
                 0.6782 
                 77.25 
                 2985.25 
                 0.1686 
                 affec 
               
               
                 RS2119292 
                 TCF4 
                 18 
                 51231961 
                 0.1306 
                 77.29 
                 2985.29 
                 0.8841 
                 affec 
               
               
                 RS2958182 
                 TCF4 
                 18 
                 51298008 
                 0.2291 
                 77.35 
                 2985.35 
                 0.6400 
                 young 
               
               
                 RS613872 
                 TCF4 
                 18 
                 51359289 
                 0.2826 
                 77.36 
                 2985.36 
                 0.5488 
                 old 
               
               
                 RS243375 
                 CHAF1A 
                 19 
                 4388089 
                 0.1945 
                 15.91 
                 3044.91 
                 0.7111 
                 young 
               
               
                 RS932276 
                 UBXD1 
                 19 
                 4390525 
                 0.0551 
                 15.93 
                 3044.93 
                 1.2588 
                 young 
               
               
                 RS9352 
                 CHAF1A 
                 19 
                 4393336 
                 0.1659 
                 15.95 
                 3044.95 
                 0.7802 
                 young 
               
               
                 RS243382 
                 CHAF1A 
                 19 
                 4393529 
                 0.1287 
                 15.95 
                 3044.95 
                 0.8904 
                 affec 
               
               
                 RS741923 
                 UBXD1 
                 19 
                 4399843 
                 0.0696 
                 16.00 
                 3045.00 
                 1.1574 
                 young 
               
               
                 RS243395 
                 UBXD1 
                 19 
                 4403497 
                 0.0972 
                 16.03 
                 3045.03 
                 1.0123 
                 young 
               
               
                 RS1044510 
                 UBXD1 
                 19 
                 4408650 
                 0.1256 
                 16.07 
                 3045.07 
                 0.9010 
                 young 
               
               
                 RS6510808 
                 UBXD1 
                 19 
                 4409911 
                 0.1791 
                 16.08 
                 3045.08 
                 0.7469 
                 young 
               
               
                 RS2913984 
                   
                 19 
                 8379580 
                 0.1217 
                 28.07 
                 3057.07 
                 0.9147 
                 young 
               
               
                 RS2396141 
                   
                 19 
                 8398574 
                 
                   0.031 
                 
                 28.17 
                 3057.17 
                 1.5072 
                 young 
               
               
                 RS2303180 
                   
                 19 
                 8401765 
                 0.5057 
                 28.18 
                 3057.18 
                 0.2961 
                 old 
               
               
                 RS3815783 
                   
                 19 
                 8409025 
                 0.1804 
                 28.22 
                 3057.22 
                 0.7438 
                 young 
               
               
                 RS6603074 
                   
                 19 
                 8411332 
                 0.1505 
                 28.23 
                 3057.23 
                 0.8225 
                 affec 
               
               
                 RS6603076 
                   
                 19 
                 8413177 
                 0.2261 
                 28.24 
                 3057.24 
                 0.6457 
                 affec 
               
               
                 RS2229531 
                 ACP5 
                 19 
                 11548195 
                 
                   0.017 
                 
                 35.57 
                 3064.57 
                 1.7645 
                 affec 
               
               
                 RS2305799 
                 ACP5 
                 19 
                 11548351 
                 
                   0.021 
                 
                 35.57 
                 3064.57 
                 1.6737 
                 old 
               
               
                 RS2071485 
                 ACP5 
                 19 
                 11549200 
                 0.0511 
                 35.57 
                 3064.57 
                 1.2916 
                 young 
               
               
                 RS2071484 
                 ACP5 
                 19 
                 11549460 
                 
                   0.027 
                 
                 35.57 
                 3064.57 
                 1.5751 
                 old 
               
               
                 RS2071483 
                 ACP5 
                 19 
                 11549539 
                 0.2532 
                 35.57 
                 3064.57 
                 0.5965 
                 affec 
               
               
                 RS2241089 
                 IFI30 
                 19 
                 18145651 
                 0.5143 
                 47.72 
                 3076.72 
                 0.2888 
                 affec 
               
               
                 RS2241090 
                 IFI30 
                 19 
                 18146751 
                 0.497 
                 47.72 
                 3076.72 
                 0.3036 
                 affec 
               
               
                 RS4808756 
                 IFI30 
                 19 
                 18149004 
                 0.972 
                 47.72 
                 3076.72 
                 0.0123 
                 affec 
               
               
                 RS7125 
                 IFI30 
                 19 
                 18149069 
                 0.0723 
                 47.72 
                 3076.72 
                 1.1409 
                 affec 
               
               
                 RS2921 
                 IFI30 
                 19 
                 18149810 
                 0.5117 
                 47.72 
                 3076.72 
                 0.2910 
                 young 
               
               
                 RS2303692 
                 ELL 
                 19 
                 18418657 
                 0.0654 
                 47.78 
                 3076.78 
                 1.1844 
                 affec 
               
               
                 HCV1399152 
                 ELL 
                 19 
                 18421282 
                 
                   0.038 
                 
                 47.78 
                 3076.78 
                 1.4202 
                 affec 
               
               
                 RS731945 
                 ELL 
                 19 
                 18428039 
                 0.2426 
                 47.79 
                 3076.79 
                 0.6151 
                 old 
               
               
                 HCV8161961 
                 ELL 
                 19 
                 18473351 
                 
                   0.037 
                 
                 47.80 
                 3076.80 
                 1.4283 
                 affec 
               
               
                 HCV8161938 
                 ELL 
                 19 
                 18479225 
                 
                   0.006 
                 
                 47.80 
                 3076.80 
                 2.2291 
                 affec 
               
               
                 RS3786874 
                 SPINT2 
                 19 
                 43450782 
                 0.4105 
                 62.56 
                 3091.56 
                 0.3867 
                 young 
               
               
                 HCV7822158 
                 SPINT2 
                 19 
                 43456912 
                 0.0743 
                 62.59 
                 3091.59 
                 1.1290 
                 young 
               
               
                 RS1006140 
                 SPINT2 
                 19 
                 43470755 
                 0.1026 
                 62.65 
                 3091.65 
                 0.9889 
                 young 
               
               
                 RS4760 
                 PLAUR 
                 19 
                 48844940 
                 0.2575 
                 67.37 
                 3096.37 
                 0.5892 
                 young 
               
               
                 RS2283628 
                 PLAUR 
                 19 
                 48854901 
                 0.1747 
                 67.37 
                 3096.37 
                 0.7577 
                 old 
               
               
                 RS399145 
                 PLAUR 
                 19 
                 48861362 
                 0.5229 
                 67.37 
                 3096.37 
                 0.2816 
                 affec 
               
               
                 RS2286960 
                 PLAUR 
                 19 
                 48863865 
                 
                   0.031 
                 
                 67.37 
                 3096.37 
                 1.5129 
                 old 
               
               
                 RS440446 
                 APOE 
                 19 
                 50101007 
                 0.2555 
                 69.50 
                 3098.50 
                 0.5926 
                 young 
               
               
                 RS769449 
                 APOE 
                 19 
                 50101842 
                 0.0989 
                 69.50 
                 3098.50 
                 1.0048 
                 old 
               
               
                 RS769450 
                 APOE 
                 19 
                 50102284 
                 0.0962 
                 69.50 
                 3098.50 
                 1.0168 
                 affec 
               
               
                 RS7412 
                 APOE 
                 19 
                 50103919 
                 0.3126 
                 69.50 
                 3098.50 
                 0.5050 
                 old 
               
               
                 RS483082 
                 APOC1 
                 19 
                 50108018 
                 0.08 
                 69.50 
                 3098.50 
                 1.0969 
                 affec 
               
               
                 RS1064725 
                 APOC1 
                 19 
                 50114401 
                 0.3498 
                 69.50 
                 3098.50 
                 0.4562 
                 young 
               
               
                 RS5157 
                 APOC2 
                 19 
                 50139001 
                 0.5997 
                 69.50 
                 3098.50 
                 0.2221 
                 young 
               
               
                 RS5120 
                 APOC2 
                 19 
                 50143460 
                 0.5398 
                 69.50 
                 3098.50 
                 0.2678 
                 young 
               
               
                 RS5126 
                 APOC2 
                 19 
                 50144269 
                 0.6604 
                 69.50 
                 3098.50 
                 0.1802 
                 young 
               
               
                 RS3760627 
                 APOC2 
                 19 
                 50149020 
                 0.2672 
                 69.50 
                 3098.50 
                 0.5732 
                 young 
               
               
                 RS2239375 
                 APOC2 
                 19 
                 50151691 
                 0.3258 
                 69.50 
                 3098.50 
                 0.4870 
                 young 
               
               
                 RS1805419 
                 FTL 
                 19 
                 54150916 
                 
                   0.02 
                 
                 74.43 
                 3103.43 
                 1.7033 
                 young 
               
               
                 RS4645887 
                 FTL 
                 19 
                 54151688 
                 0.0859 
                 74.44 
                 3103.44 
                 1.0660 
                 affec 
               
               
                 RS2387583 
                 FTL 
                 19 
                 54153117 
                 
                   0.041 
                 
                 74.44 
                 3103.44 
                 1.3851 
                 young 
               
               
                 RS1042265 
                 GYS1 
                 19 
                 54163632 
                 
                   0.011 
                 
                 74.46 
                 3103.46 
                 1.9706 
                 young 
               
               
                 RS2270938 
                 GYS1 
                 19 
                 54165839 
                 0.0706 
                 74.46 
                 3103.46 
                 1.1512 
                 affec 
               
               
                 HCV1997111 
                 LAIR1 
                 19 
                 59544316 
                 0.3295 
                 90.99 
                 3119.99 
                 0.4821 
                 old 
               
               
                 RS2287824 
                 LAIR1 
                 19 
                 59554712 
                 0.1514 
                 91.01 
                 3120.01 
                 0.8199 
                 affec 
               
               
                 RS2664538 
                 MMP9 
                 20 
                 45325647 
                 0.5834 
                 64.88 
                 3190.88 
                 0.2340 
                 young 
               
               
                 RS13969 
                 MMP9 
                 20 
                 45328255 
                 0.0526 
                 64.88 
                 3190.88 
                 1.2790 
                 old 
               
               
                 RS2274756 
                 MMP9 
                 20 
                 45328533 
                 0.3632 
                 64.88 
                 3190.88 
                 0.4399 
                 young 
               
               
                 RS13925 
                 MMP9 
                 20 
                 45330387 
                 0.4266 
                 64.88 
                 3190.88 
                 0.3700 
                 young 
               
               
                 RS9509 
                 MMP9 
                 20 
                 45330575 
                 0.1485 
                 64.88 
                 3190.88 
                 0.8283 
                 young 
               
               
                 RS2766669 
                 ZNF217 
                 20 
                 52863648 
                 
                   0.048 
                 
                 80.63 
                 3206.63 
                 1.3152 
                 young 
               
               
                 RS743466 
                 CSTB 
                 21 
                 44047207 
                 0.159 
                 52.50 
                 3274.50 
                 0.7986 
                 young 
               
               
                 RS2838363 
                 CSTB 
                 21 
                 44047341 
                 0.404 
                 52.50 
                 3274.50 
                 0.3936 
                 affec 
               
               
                 RS6375 
                 CSTB 
                 21 
                 44051731 
                 0.9802 
                 52.50 
                 3274.50 
                 0.0087 
                 old 
               
               
                 RS3761385 
                 CSTB 
                 21 
                 44054557 
                 
                   0.024 
                 
                 52.50 
                 3274.50 
                 1.6234 
                 old 
               
               
                 HCV11479371 
                 SMTN 
                 22 
                 29789771 
                 
                   0.4881 
                 
                 29.03 
                 3309.03 
                 0.3115 
                 young 
               
               
                 HCV2628881 
                 SMTN 
                 22 
                 29806208 
                 0.4063 
                 29.04 
                 3309.04 
                 0.3912 
                 young 
               
               
                 HCV2628867 
                 SMTN 
                 22 
                 29817679 
                 0.0834 
                 29.05 
                 3309.05 
                 1.0788 
                 old 
               
               
                 HCV2628861 
                 SMTN 
                 22 
                 29819997 
                 0.4669 
                 29.05 
                 3309.05 
                 0.3308 
                 affec 
               
               
                 HCV2628858 
                 SMTN 
                 22 
                 29822433 
                 0.4293 
                 29.05 
                 3309.05 
                 0.3672 
                 young 
               
               
                 RS5757424 
                 APOBEC3D 
                 22 
                 37658819 
                 0.3269 
                 46.12 
                 3326.12 
                 0.4856 
                 affec 
               
               
                 RS5757425 
                 APOBEC3D 
                 22 
                 37662522 
                 0.1552 
                 46.13 
                 3326.13 
                 0.8091 
                 young 
               
               
                 RS6001388 
                 APOBEC3D 
                 22 
                 37662892 
                 0.2216 
                 46.13 
                 3326.13 
                 0.6544 
                 affec 
               
               
                   
               
            
           
         
       
     
     A detailed list of the top genes and SNPs in those genes ranked by p-value for each gene is included as Table 2 below. Genes identified having at least 1 SNP with a p-value less than 0.10 are shown in bold. Genes were identified from logistic regression analysis of three models only: OA vs. ON, YA vs. ON and YA vs. OA. The column headers represent the following: GENE: Gene name (HUGO ID); Gene alias: Non-HUGO ID gene aliases or previous gene names; Meta Rank: Gene rank from the David Seo/Mike West microarray expression study [PMID:15297278]; P val  Rank: Gene rank based on lowest Cathgen p-value for any SNP/model in that gene (lowest p-value has rank of 1); Startloc: Gene&#39;s base pair start location from NCBI build 35; Chr: Chromosome; # SNPS: Number of SNPs in that gene genotyped in Cathgen individuals; Lowest p-value: Lowest p-value for any SNP/model in that gene from logistic regression analysis of groups C1+C2 (1037 individuals); adjusted for sex and ethnicity; Model: SNP model with the lowest p-value (responsible for that gene&#39;s Top Gene p-value ranking); Other models &lt;0.10: All other SNPs, models in that gene with a p-value &lt;0.10. Abbreviations are as follows: A, Allele test; G, Genotype test; YVN, Young Affected v. Old Normal; OVN, Old Affected v. Old Normal; YVO, Young Affected v. Old Affected 
     
       
         
           
               
               
               
               
               
               
               
               
             
               
                 TABLE 2 
               
               
                   
               
               
                   
                 Meta 
                 P val 
                   
                   
                 Lowest 
                   
                   
               
               
                 GENE 
                 Rank 
                 Rank 
                 Startloc 
                 CH 
                 p-value 
                 Model 
                 Other models &lt;.10 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 AIM1L 
                 230 
                 1 
                 26356066 
                 1 
                 0.0001 
                 RS4454539, 
                 RS4454539, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
                 RS4454539, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4454539, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4454539, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4659431, A, OVN 
               
               
                 PLA2G7 
                 0 
                 2 
                 46780013 
                 6 
                 0.0001 
                 RS1805017, 
                 RS9381475, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
                 RS9381475, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1805017, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1862008, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1862008, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1051931, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS9381475, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1051931, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1051931, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS9381475, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1862008, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1862008, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1051931, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1805017, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1805017, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1805017, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1805018, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1805018, G, YVN 
               
               
                 OR7E29P 
                 0 
                 4 
                 126913676 
                 3 
                 0.0003 
                 RS2979310, 
                 RS2979310, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
                 RS2979310, A, OVN 
               
               
                 PLN 
                 108 
                 5 
                 118986778 
                 6 
                 0.0003 
                 RS1051429, 
                 RS1051429, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
                 RS3734382, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3734382, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1051429, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1051429, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 6P0326, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1051429, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3734382, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 6P0326, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 6P0326, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3734382, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 6P0326, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3752581, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 6P0324, A, YVO 
               
               
                 PTPN6 
                 187 
                 6 
                 6911553 
                 12 
                 0.0003 
                 RS7310161, 
                 RS7978658, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
                 RS7978658, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS7310161, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS7310161, A, YVN 
               
               
                 CIORF38 
                 32 
                 7 
                 27883228 
                 1 
                 0.0005 
                 RS3766398, 
                 RS3766398, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
                 RS3766398, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS12048235, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3766398, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6564, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6564, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS12048235, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1467464, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6564, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1467464, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS12048235, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1467465, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS12048235, G, YVO 
               
               
                 GATA2 
                 0 
                 8 
                 129680970 
                 3 
                 0.0006 
                 RS2335052, 
                 RS6439129, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
                 RS1573858, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2335052, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6439129, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2335052, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2335052, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1573858, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2713603, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1573858, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2713603, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2713603, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2713603, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6439129, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3803, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3803, A, YVN 
               
               
                 IL7R 
                 0 
                 9 
                 35892748 
                 5 
                 0.0006 
                 RS1494555, 
                 RS1494555, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
                 RS1494555, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1494555, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS987106, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2228141, G, YVO 
               
               
                 MYLK 
                 0 
                 10 
                 124813835 
                 3 
                 0.0007 
                 RS16834817, 
                 RS16834817, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
                 HCV1602689, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 HCV1602689, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS16834817, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 HCV1602689, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4118366, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS16834817, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2682215, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2682239, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4118366, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4461370, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 HCV1602689, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4461370, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2682215, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2700358, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2682229, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2700358, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2682239, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2682229, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS11717814, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS16834826, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2605417, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1343700, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS820371, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2682215, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2700408, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2605417, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4118366, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2700408, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4461370, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1343700, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1343700, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4118366, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2700358, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2682215, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2682239, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2682229, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS11717814, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2700408, G, YVO 
               
               
                 ANPEP 
                 146 
                 11 
                 88129131 
                 15 
                 0.0008 
                 RS10584, A, 
                 RS10584, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 YVO 
                 RS25653, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS25653, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS10584, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS10584, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS25653, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS25653, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1992250, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1439119, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1992250, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1439119, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS7168793, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1439119, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS7168793, G, YVO 
               
               
                 PIK3R4 
                 0 
                 12 
                 131880476 
                 3 
                 0.0013 
                 RS900989, 
                 RS900989, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
                 RS10934955, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS10934955, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS11710068, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS11710068, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS10934954, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS10934954, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4682627, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4682627, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS900989, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS10934955, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS900989, A, YVO 
               
               
                 RPLP2 
                 0 
                 13 
                 799965 
                 11 
                 0.0016 
                 RS4131364, 
                 RS4131364, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
                 RS4131364, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4131364, A, YVO 
               
               
                 OLR1 
                 145 
                 14 
                 10202171 
                 12 
                 0.002 
                 RS2742113, 
                 RS2742113, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
                 RS3741860, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3741860, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 12P0322, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1050286, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 12P0322, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1050286, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2742113, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3736233, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3736233, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 12P0322, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3736232, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1050286, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3736233, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3736232, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3736232, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 12P0322, A, YVO 
               
               
                 PNPLA2 
                 0 
                 15 
                 808902 
                 11 
                 0.002 
                 RS6597979, 
                 RS1138714, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
                 RS1138714, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6597979, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1138714, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6597979, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1135628, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6597979, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1135628, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1138714, A, YVO 
               
               
                 TCF4 
                 0 
                 16 
                 51046093 
                 18 
                 0.0021 
                 RS1893430, 
                 RS1893430, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
                 RS2276195, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1893430, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2276195, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1261076, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1893430, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2276195, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2119292, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2119292, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1440476, A, YVO 
               
               
                 ACP5 
                 31 
                 17 
                 11546477 
                 19 
                 0.0022 
                 RS2229531, 
                 RS2305799, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
                 RS2071484, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2229531, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2071484, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2229531, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2071484, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2071484, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2229531, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2305799, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2305799, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2305799, A, YVO 
               
               
                 SELP 
                 0 
                 18 
                 166289748 
                 1 
                 0.0028 
                 RS6133, A, 
                 RS6132, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 YVO 
                 RS6132, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6133, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6133, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6132, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6136, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6133, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6132, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6136, G, YVO 
               
               
                 BAX 
                 0 
                 19 
                 54149998 
                 19 
                 0.0032 
                 RS1805419, 
                 RS1805419, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
                 RS4645887, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS905238, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4645887, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4645887, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4645887, A, YVN 
               
               
                 CPNE4 
                 0 
                 20 
                 132736261 
                 3 
                 0.0036 
                 RS6802186, 
                 RS6802186, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
                 RS1463518, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1870713, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6802186, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1463518, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1870713, G, YVO 
               
               
                 TAL1 
                 0 
                 21 
                 47393984 
                 1 
                 0.0043 
                 1P0330, G, 
                 1P0330, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 OVN 
                 1P0330, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 1P0330, G, YVN 
               
               
                 KLF15 
                 0 
                 22 
                 127544177 
                 3 
                 0.0049 
                 RS7622890, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
               
               
                 ABCB1 
                 0 
                 23 
                 86777599 
                 7 
                 0.0051 
                 RS1045642, 
                 RS1128503, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
                 RS1045642, G, YVN 
               
               
                 LHFPL2 
                 147 
                 24 
                 77816810 
                 5 
                 0.0051 
                 RS1561735, 
                 RS1561735, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
                 RS6872179, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6872179, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1561735, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS11948997, A, YVN 
               
               
                 ITGAX 
                 94 
                 25 
                 31274010 
                 16 
                 0.0055 
                 RS4264407, 
                 RS4264407, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
                 RS1140195, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4264407, G, OVN 
               
               
                 LOC389142 
                 0 
                 26 
                 119206321 
                 3 
                 0.0057 
                 RS1486336, 
                 RS1486336, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
                 RS1968010, A, OVN 
               
               
                 PLXNC1 
                 88 
                 27 
                 93044967 
                 12 
                 0.0058 
                 RS2305971, 
                 RS1681866, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
                 RS1681866, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2305971, A, YVN 
               
               
                 SLA 
                 46 
                 28 
                 134118156 
                 8 
                 0.0058 
                 RS2252807, 
                 RS2252807, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
                 RS1533910, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1533910, A, OVN 
               
               
                 ELL 
                 0 
                 29 
                 18414475 
                 19 
                 0.0063 
                 RS6512269, 
                 RS7252848, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
                 RS748609, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6512269, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS748609, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2303692, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS748609, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS7252848, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2303692, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS7252848, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6512269, G, OVN 
               
               
                 NPY 
                 0 
                 30 
                 24097047 
                 7 
                 0.0065 
                 RS5574, A, 
                 RS5574, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 YVN 
                 RS9785023, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS9785023, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS5574, A, YVO 
               
               
                 IGSF11 
                 0 
                 31 
                 120102171 
                 3 
                 0.0066 
                 RS1468738, 
                 RS1468738, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
                 RS2160052, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4687959, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2160052, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2903250, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2903250, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4687959, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4687959, A, YVN 
               
               
                 ITPK1 
                 0 
                 32 
                 92473012 
                 14 
                 0.0066 
                 HCV1259613, 
                 RS2402226, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
                 RS2402226, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2402226, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 HCV1259613, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS875395, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4905043, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1740595, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2402226, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1740595, A, YVO 
               
               
                 ASB1 
                 174 
                 33 
                 239117626 
                 2 
                 0.007 
                 RS507812, 
                 RS507812, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
                 RS507812, G, YVN 
               
               
                 SELB 
                 0 
                 34 
                 129355049 
                 3 
                 0.007 
                 RS2955103, 
                 RS2955103, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
                 RS760383, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2811529, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2811529, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2687720, G, OVN 
               
               
                 LOC131873 
                 0 
                 35 
                 131718695 
                 3 
                 0.0075 
                 RS1508520, 
                 RS6439249, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
                 RS6439249, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS9823913, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1508520, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS9823913, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6439249, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6439249, A, YVO 
               
               
                 PCCA 
                 0 
                 36 
                 99539338 
                 13 
                 0.0086 
                 RS9518035, 
                 RS9518035, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
                 RS1296332, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS9518016, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS9518016, A, YVN 
               
               
                 HAPIP 
                 0 
                 37 
                 125296275 
                 3 
                 0.0087 
                 RS2272486, 
                 RS13075202, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
                 RS7621976, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2272486, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS13075202, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS13075202, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS333284, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS7621976, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2272486, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS13075202, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS7621976, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS333284, G, OVN 
               
               
                 PLAUR 
                 119 
                 38 
                 48842449 
                 19 
                 0.0088 
                 RS2286960, 
                 RS2286960, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
                 RS2286960, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2286960, A, YVN 
               
               
                 SIDT1 
                 0 
                 39 
                 114734183 
                 3 
                 0.0099 
                 RS11929640, 
                 RS11929640, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
                 RS11929640, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS11929640, A, OVN 
               
               
                 RPN1 
                 0 
                 40 
                 129821511 
                 3 
                 0.0106 
                 RS4857914, 
                 RS2712371, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
                 RS4857914, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1127030, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1697, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4857914, G, OVN 
               
               
                 BPAG1 
                 63 
                 41 
                 56430744 
                 6 
                 0.0128 
                 RS2613118, 
                 RS2024751, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
                 RS2024751, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1014310, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1014310, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2613118, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1014310, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1024196, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1024196, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2613118, G, YVN 
               
               
                 ROR2 
                 0 
                 42 
                 91564439 
                 9 
                 0.0139 
                 RS1881385, 
                 RS10116351, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
                 RS10116351, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4744098, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4744098, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4744098, A, OVN 
               
               
                 MMP12 
                 71 
                 43 
                 102238686 
                 11 
                 0.0144 
                 RS674546, 
                 RS674546, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
                 RS674546, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1277718, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS674546, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2276109, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2276109, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS652438, G, YVN 
               
               
                 GAP43 
                 0 
                 44 
                 116825142 
                 3 
                 0.0148 
                 RS2918208, 
                 RS14360, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
                 RS2918208, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2918208, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS14360, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2918208, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS14360, G, YVO 
               
               
                 FSTL1 
                 0 
                 45 
                 121595817 
                 3 
                 0.0155 
                 RS1259333, 
                 RS1147707, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
                 RS1259333, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1515577, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2272515, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2272515, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2272515, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2488, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1515577, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1147707, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2488, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1057231, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1147707, A, YVO 
               
               
                 MAP4 
                 152 
                 46 
                 47868362 
                 3 
                 0.0158 
                 RS2166770, 
                 RS2166770, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
                 RS319689, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS319689, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6442089, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS319689, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6442089, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2166770, G, YVN 
               
               
                 ZNF217 
                 53 
                 47 
                 51617019 
                 20 
                 0.016 
                 RS1326862, 
                 RS1326862, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
                 RS2766669, A, YVN 
               
               
                 ALOX5 
                 73 
                 48 
                 45189692 
                 10 
                 0.0161 
                 RS3740107, 
                 RS3740107, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
                 RS3740107, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2242332, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3740107, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS892691, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS892691, A, YVO 
               
               
                 NPHP3 
                 0 
                 49 
                 133759684 
                 3 
                 0.0163 
                 RS2369832, 
                 RS2369832, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
               
               
                 GPNMB 
                 189 
                 50 
                 23059626 
                 7 
                 0.0166 
                 RS199347, 
                 RS199347, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
                 RS199347, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS199348, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS199355, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS199355, G, YVO 
               
               
                 SPP1 
                 2 
                 51 
                 89253981 
                 4 
                 0.0174 
                 RS12502049, 
                 RS12502049, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
               
               
                 ZNF80 
                 0 
                 52 
                 115437790 
                 3 
                 0.0188 
                 RS6438191, 
                 RS3732782, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
                 RS6438191, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3732782, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6438191, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6438191, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3732782, A, OVN 
               
               
                 MGP 
                 0 
                 53 
                 14926094 
                 12 
                 0.0189 
                 RS1800801, 
                 RS4236, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
                 RS1800801, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2430738, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2430737, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS4236, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2430738, A, OVN 
               
               
                 C3ORF15 
                 0 
                 54 
                 0 
                 3 
                 0.0199 
                 HCV369572, 
                 HCV369572, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
               
               
                 NEK11 
                 0 
                 55 
                 132228421 
                 3 
                 0.0208 
                 RS16835847, 
                 RS16835847, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
                 RS16835847, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS16835847, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2033182, A, OVN 
               
               
                 POLQ 
                 0 
                 56 
                 122632973 
                 3 
                 0.0218 
                 RS2030531, 
                 RS2030531, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
                 RS2030531, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2030531, G, YVO 
               
               
                 ADFP 
                 67 
                 57 
                 19105760 
                 9 
                 0.022 
                 RS3824369, 
                 RS3824369, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
                 RS3824369, A, OVN 
               
               
                 UBXD1 
                 0 
                 58 
                 4396009 
                 19 
                 0.0223 
                 RS932276, 
                 RS741923, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
                 RS11909, G, YVN 
               
               
                 38413 
                 0 
                 59 
                 8389289 
                 19 
                 0.0224 
                 RS6603068, 
                 RS6603068, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
                 RS2913984, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6603068, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6603068, A, YVN 
               
               
                 FLJ46299 
                 0 
                 60 
                 0 
                 3 
                 0.0229 
                 RS1014470, 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
               
               
                 ZBTB20 
                 0 
                 61 
                 115540215 
                 3 
                 0.0229 
                 RS1818757, 
                 RS1818757, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
                 RS1357016, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1818757, G, OVN 
               
               
                 HLA- 
                 8 
                 62 
                 32817199 
                 6 
                 0.0229 
                 RS5018343, 
                 RS2213566, A, OVN 
               
               
                 DQA2 
                   
                   
                   
                   
                   
                 G, OVN 
                 RS2213566, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS5018343, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2051600, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2051600, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2395252, A, YVO 
               
               
                 ZXDC 
                 0 
                 63 
                 127639143 
                 3 
                 0.0232 
                 RS1799404, 
                 RS1799404, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
                 RS1799404, A, OVN 
               
               
                 GRN 
                 69 
                 64 
                 39778174 
                 17 
                 0.0237 
                 RS3815057, 
                 RS3859268, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
                 RS3815057, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3815057, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3815057, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3859268, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3859268, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS3785817, A, OVN 
               
               
                 PSCD1 
                 0 
                 65 
                 74181727 
                 17 
                 0.0244 
                 RS3936118, 
                 RS1871935, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
                 RS1384367, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 HCV12126963, A, YVO 
               
               
                 GYS1 
                 0 
                 66 
                 54163195 
                 19 
                 0.0257 
                 RS2270938, 
                 RS2270938, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
                 RS1042265, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1042265, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2270938, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2270938, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1042265, G, OVN 
               
               
                 C14ORF132 
                 11 
                 67 
                 95575431 
                 14 
                 0.0265 
                 RS2104290, 
                 RS1058102, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
                 RS2104290, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1058102, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1058102, G, OVN 
               
               
                 CD80 
                 0 
                 68 
                 120725832 
                 3 
                 0.0266 
                 HCV387937, 
                 RS1523311, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
                 RS1523311, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 HCV387937, G, YVN 
               
               
                 CDGAP 
                 0 
                 69 
                 120495910 
                 3 
                 0.0267 
                 RS10934490, 
                 RS10934490, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
               
               
                 LMOD1 
                 149 
                 70 
                 198586920 
                 1 
                 0.0274 
                 RS2819366, 
                 RS2819366, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
                 RS7528681, A, YVN 
               
               
                 SLC41A3 
                 0 
                 71 
                 127207903 
                 3 
                 0.0277 
                 HCV123667, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
               
               
                 HOXD1 
                 0 
                 72 
                 176878814 
                 2 
                 0.0278 
                 RS1446575, 
                 RS1446575, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
               
               
                 STAT5A 
                 12 
                 73 
                 37693865 
                 17 
                 0.0284 
                 RS3198502, 
                 RS3198502, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
               
               
                 OPRM1 
                 0 
                 74 
                 154452590 
                 6 
                 0.0303 
                 RS609148, 
                 RS524731, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
                 RS609148, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS524731, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS524731, G, YVN 
               
               
                 ITPR2 
                 162 
                 75 
                 26765487 
                 12 
                 0.0305 
                 RS2291264, 
                 RS2291264, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
                 RS1449568, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2291264, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1449568, A, YVO 
               
               
                 HIF1A 
                 0 
                 76 
                 61231992 
                 14 
                 0.0307 
                 RS3783752, 
                 RS2301113, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
               
               
                 PKD2 
                 19 
                 77 
                 89285999 
                 4 
                 0.0314 
                 RS2728110, 
                 RS2728116, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
                 RS2728116, G, YVO 
               
               
                 STEAP 
                 35 
                 78 
                 89428340 
                 7 
                 0.032 
                 RS2961269, 
                 RS2158746, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
                 RS2158746, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2158746, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2158746, G, YVO 
               
               
                 AGTR1 
                 0 
                 79 
                 149898363 
                 3 
                 0.0322 
                 RS3772587, 
                 RS9849625, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
                 RS389566, A, YVO 
               
               
                 NDUFB4 
                 0 
                 80 
                 121797818 
                 3 
                 0.0326 
                 HCV112367 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 38, G, YVN 
               
               
                 GLRA3 
                 0 
                 81 
                 175938660 
                 4 
                 0.0336 
                 RS4695942, 
                 RS4695942, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
                 RS4695942, A, YVN 
               
               
                 MEF2A 
                 0 
                 82 
                 97923738 
                 15 
                 0.0338 
                 HCV11709390, 
                 RS325408, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
               
               
                 STXBP5L 
                 0 
                 83 
                 122104941 
                 3 
                 0.0341 
                 RS4505627, 
                 RS4505627, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
               
               
                 APOBEC3D 
                 0 
                 84 
                 37741952 
                 22 
                 0.0343 
                 RS5757425, 
                 RS5757425, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
               
               
                 FMNL1 
                 0 
                 85 
                 40655075 
                 17 
                 0.0352 
                 RS1989229, 
                 RS1552458, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
                 RS1989229, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1552458, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1801353, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1552458, A, OVN 
               
               
                 PLXND1 
                 97 
                 86 
                 130756716 
                 3 
                 0.0361 
                 RS2245285, 
                 RS2245285, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
                 RS2245278, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2245285, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2245285, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2245278, A, OVN 
               
               
                 ATP2C1 
                 0 
                 87 
                 132095533 
                 3 
                 0.0368 
                 RS2669869, 
                 RS2669869, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
                 RS2669869, A, YVN 
               
               
                 RUVBL1 
                 0 
                 88 
                 129282501 
                 3 
                 0.0378 
                 RS7632756, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
               
               
                 CASR 
                 0 
                 89 
                 123455485 
                 3 
                 0.0379 
                 RS12635478, 
                 RS12635478, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
                 RS13095172, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS13095172, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 HCV1412358, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS13095172, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2270917, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1501899, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS2270917, G, YVO 
               
               
                 PTPRR 
                 0 
                 90 
                 69318129 
                 12 
                 0.0385 
                 HCV155408, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
               
               
                 SMPDL3A 
                 96 
                 91 
                 123152120 
                 6 
                 0.0396 
                 RS1385681, 
                 RS1385681, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
                 RS1385681, A, YVN 
               
               
                 APOD 
                 0 
                 92 
                 unmapped 
                 3 
                 0.0397 
                 RS13303036, 
                 RS13303036, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
               
               
                 APG3L 
                 0 
                 93 
                 113734236 
                 3 
                 0.0401 
                 RS2638037, 
                 RS2638037, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
               
               
                 FLJ35880 
                 0 
                 94 
                 131642165 
                 3 
                 0.0406 
                 RS322115, 
                 RS819086, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
                 RS9883988, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS819086, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS9883988, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS322115, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS819086, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS819091, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS9883988, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS9883988, A, OVN 
               
               
                 TMCC1 
                 0 
                 95 
                 130850232 
                 3 
                 0.0406 
                 RS2811343, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
               
               
                 CD96 
                 0 
                 96 
                 112743546 
                 3 
                 0.041 
                 RS1553970, 
                 RS1553970, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
               
               
                 C1QB 
                 118 
                 97 
                 22725046 
                 1 
                 0.0419 
                 RS292007, 
                 RS10580, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
                 RS292007, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS291988, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS10580, A, YVO 
               
               
                 CTSD 
                 30 
                 98 
                 1730561 
                 11 
                 0.0419 
                 RS17571, G, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 YVN 
               
               
                 FLI1 
                 0 
                 99 
                 128069239 
                 11 
                 0.0421 
                 RS660407, 
                 RS497714, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
               
               
                 MMP9 
                 178 
                 100 
                 44070954 
                 20 
                 0.0421 
                 RS13969, G, 
                 RS13969, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 OVN 
               
               
                 TCIRG1 
                 190 
                 101 
                 67563059 
                 11 
                 0.0435 
                 RS2075609, 
                 RS2075609, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
                 RS2075609, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS906713, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS11481, A, OVN 
               
               
                 ITGB5 
                 0 
                 102 
                 125964486 
                 3 
                 0.0452 
                 RS3772831, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
               
               
                 FLJ25414 
                 0 
                 103 
                 40687543 
                 17 
                 0.046 
                 HCV9267944, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
               
               
                 NR1H3 
                 68 
                 104 
                 47236106 
                 11 
                 0.0463 
                 RS3758673, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
               
               
                 HSPBAP1 
                 0 
                 105 
                 123941536 
                 3 
                 0.0468 
                 HCV1402346, 
                 HCV1402346, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
               
               
                 APOC1 
                 1 
                 106 
                 50109419 
                 19 
                 0.0469 
                 RS1064725, 
                 RS1064725, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
               
               
                 THPO 
                 0 
                 107 
                 185572475 
                 3 
                 0.0475 
                 RS6142, A, 
                 RS6142, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 YVO 
                 RS6142, G, YVN 
               
               
                 FTL 
                 0 
                 108 
                 54160378 
                 19 
                 0.0476 
                 RS918546, 
                 RS918546, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
               
               
                 HADHSC 
                 124 
                 109 
                 109268516 
                 4 
                 0.0479 
                 RS221330, 
                 RS221330, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
               
               
                 ALOX5AP 
                 0 
                 110 
                 30207669 
                 13 
                 0.0481 
                 RS3803277, 
                 RS3803277, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
               
               
                 LAIR1 
                 39 
                 111 
                 59557945 
                 19 
                 0.0493 
                 RS2287824, 
                 RS2287824, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
                 RS1985841, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1985841, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS730592, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS730592, G, YVN 
               
               
                 UPP1 
                 79 
                 112 
                 47901481 
                 7 
                 0.0524 
                 RS6463462, 
                 RS7804178, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
                 RS6463462, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS7804178, G, OVN 
               
               
                 LAPTM5 
                 7 
                 113 
                 30874409 
                 1 
                 0.0527 
                 RS3795438, 
                 1P0260, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
               
               
                 CSTA 
                 0 
                 114 
                 123526773 
                 3 
                 0.0528 
                 RS17589, A, 
                 RS17589, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 YVO 
                 RS17589, G, OVN 
               
               
                 ADCY5 
                 0 
                 115 
                 124486089 
                 3 
                 0.053 
                 RS4678030, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
               
               
                 PHLDB2 
                 0 
                 116 
                 113061333 
                 3 
                 0.0531 
                 RS1282980, 
                 RS1282980, A, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
               
               
                 GM2A 
                 40 
                 117 
                 150612837 
                 5 
                 0.0533 
                 RS153450, 
                 RS153450, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
                 RS2277028, A, OVN 
               
               
                 NUDT16 
                 0 
                 118 
                 132583405 
                 3 
                 0.0536 
                 RS11914980, 
                 RS11914980, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
               
               
                 ACSL1 
                 0 
                 119 
                 186051899 
                 4 
                 0.0547 
                 RS3792311, 
                 RS3749233, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
                 RS2280297, G, OVN 
               
               
                 VAMP5 
                 10 
                 120 
                 85723189 
                 2 
                 0.056 
                 RS2289976, 
                 RS12888, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
                 RS2289976, A, OVN 
               
               
                 ACP2 
                 4 
                 121 
                 47217429 
                 11 
                 0.0568 
                 RS2167079, 
                 RS2167079, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
               
               
                 HLA- 
                 9 
                 122 
                 33140772 
                 6 
                 0.0571 
                 RS1042174, 
                 RS1042174, G, OVN 
               
               
                 DPA1 
                   
                   
                   
                   
                   
                 A, OVN 
               
               
                 TUBA3 
                 0 
                 123 
                 47864852 
                 12 
                 0.0575 
                 RS2016107, 
                 RS7954530, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
                 RS1039225, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1874908, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS6580703, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1039225, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                   
                 RS1056875, A, OVN 
               
               
                 MMP7 
                 92 
                 124 
                 101896449 
                 11 
                 0.0578 
                 RS609887, 
                 RS609887, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
               
               
                 H41 
                 0 
                 125 
                 134775272 
                 3 
                 0.058 
                 RS1842155, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
               
               
                 NR1I2 
                 0 
                 126 
                 120982021 
                 3 
                 0.0587 
                 RS1523130, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
               
               
                 FGFR2 
                 28 
                 127 
                 122473377 
                 10 
                 0.06 
                 RS2071616, 
                 RS1047100, G, YVO 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
               
               
                 GBA 
                 0 
                 128 
                 152017317 
                 1 
                 0.0661 
                 RS1045253, 
                 RS4043, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
               
               
                 CHAF1A 
                 0 
                 129 
                 4353661 
                 19 
                 0.0667 
                 RS243375, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
               
               
                 GSK3B 
                 0 
                 130 
                 121028215 
                 3 
                 0.0679 
                 RS12638973, 
                 RS12638973, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
               
               
                 DOCK2 
                 70 
                 131 
                 168996871 
                 5 
                 0.068 
                 RS11740057, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
               
               
                 URB 
                 0 
                 132 
                 113806101 
                 3 
                 0.0697 
                 RS3843366, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
               
               
                 HCLS1 
                 241 
                 133 
                 122832937 
                 3 
                 0.0711 
                 RS2070180, 
                 RS11714406, G, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
                 RS11716984, G, YVN 
               
               
                 CD200R1 
                 0 
                 134 
                 114122746 
                 3 
                 0.0736 
                 RS9870568, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVO 
               
               
                 SLCO2B1 
                 6 
                 135 
                 74539809 
                 11 
                 0.0736 
                 RS2851109, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVO 
               
               
                 B4GALT4 
                 0 
                 136 
                 120413279 
                 3 
                 0.0746 
                 RS4687841, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
               
               
                 PLCXD2 
                 0 
                 137 
                 112876213 
                 3 
                 0.0777 
                 RS1877575, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
               
               
                 FABP7 
                 0 
                 138 
                 123142345 
                 6 
                 0.0816 
                 HCV31425, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
               
               
                 CAMKK2 
                 0 
                 139 
                 120138217 
                 12 
                 0.0835 
                 RS25644, G, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 YVN 
               
               
                 FCGR1A 
                 140 
                 140 
                 146567361 
                 1 
                 0.0835 
                 RS1050204, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
               
               
                 SELL 
                 0 
                 141 
                 166391466 
                 1 
                 0.0839 
                 RS1051091, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 A, YVN 
               
               
                 SELE 
                 0 
                 142 
                 166423440 
                 1 
                 0.085 
                 RS5356, A, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 YVN 
               
               
                 HNRPM 
                 0 
                 143 
                 8415651 
                 19 
                 0.0856 
                 RS6603076, 
                 RS6603076, G, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
               
               
                 MGC45840 
                 0 
                 144 
                 819297 
                 11 
                 0.0869 
                 RS4075289, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 A, OVN 
               
               
                 F5 
                 0 
                 145 
                 166215067 
                 1 
                 0.0896 
                 RS4524, G, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 OVN 
               
               
                 SMTN 
                 0 
                 146 
                 29801858 
                 22 
                 0.0898 
                 RS1004243, 
                 RS917208, A, OVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, OVN 
               
               
                 RAI3 
                 25 
                 147 
                 12952451 
                 12 
                 0.0918 
                 RS850932, 
                 RS850932, A, YVN 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
               
               
                 HLA- 
                 86 
                 148 
                 32515646 
                 6 
                 0.0925 
                 HCV2455646, 
                 none 
               
               
                 DRA 
                   
                   
                   
                   
                   
                 G, YVN 
               
               
                 CSTB 
                 20 
                 149 
                 44018260 
                 21 
                 0.0944 
                 RS743466, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
               
               
                 FLJ12592 
                 0 
                 150 
                 0 
                 3 
                 0.0963 
                 RS6776500, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
               
               
                 TAGLN3 
                 0 
                 151 
                 113200332 
                 3 
                 0.0972 
                 RS774763, 
                 none 
               
               
                   
                   
                   
                   
                   
                   
                 G, YVN 
               
               
                   
               
            
           
         
       
     
     While all candidates listed in Table 2 must be considered very strong candidates, the results of these analyses very strongly implicate several genes in the development of atherosclerosis as measured by CADi. The following is a description of the genes in Table 2: AIM1 L: Absent in melanoma 1-like; PLA2G7: Platelet-activating factor acetylhydrolase precursor (EC 3.1.1.47) (PAF acetylhydrolase) (PAF 2-acylhydrolase) (LDL-associated phospholipase A2) (LDL-PLA(2)) (2-acetyl-1-alkylglycerophosphocholine esterase) (1-alkyl-2-acetylglycerophosphocholine esterase); OR7E29P: olfactory receptor, family 7, subfamily E, member 29 pseudogene; PLN: Cardiac phospholamban (PLB); PTPN6: Protein-tyrosine phosphatase, non-receptor type 6 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Hematopoietic cell protein-tyrosine phosphatase) (SH-PTP1) (Protein-tyrosine phosphatase SHP-1); C1ORF38: ICB-1beta (Clorf38 protein); GATA2: Endothelial transcription factor GATA-2; IL7R: Interleukin-7 receptor alpha chain precursor (IL-7R-alpha) (CDw127) (CD127 antigen); MYLK: Myosin light chain kinase, smooth muscle and non-muscle isozymes (EC 2.7.1.117) (MLCK) [Contains: Telokin (Kinase related protein) (KRP)]; ANPEP: Aminopeptidase N (EC 3.4.11.2) (hAPN) (Alanyl aminopeptidase) (Microsomal aminopeptidase) (Aminopeptidase M) (gp150) (Myeloid plasma membrane glycoprotein CD13); PIK3R4: phosphoinositide-3-kinase, regulatory subunit 4, pISO; RPLP2: 60S acidic ribosomal protein P2; OLR1: OXIDISED LOW DENSITY LIPOPROTEIN (LECTIN-LIKE) RECEPTOR 1; SCAVENGER RECEPTOR CLASS E, MEMBER 1; PNPLA2: patatin-like phospholipase domain containing 2; TCF4: Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (SL3-3 enhancer factor 2) (SEF-2); ACP5: TARTRATE RESISTANT ACID PHOSPHATASE TYPE 5 PRECURSOR (EC 3.1.3.2) (TR-AP) (TARTRATE-RESISTANT ACID ATPASE) (TRATPASE); SELP: P-selectin precursor (Granule membrane protein 140) (GMP-140) (PADGEM) (CD62P) (Leukocyte-endothelial cell adhesion molecule 3) (LECAM3); BAX: BAX protein, cytoplasmic isoform delta; CPNE4: Copine-4 (Copine IV) (Copine-8); TALI: T-cell acute lymphocytic leukemia-1 protein (TAL-1 protein) (Stem cell protein) (T-cell leukemia/lymphoma-5 protein); KLF15: Krueppel-like factor 15 (Kidney-enriched kruppel-like factor); ABCB1: Multidrug resistance protein 1 (P-glycoprotein 1) (CD243 antigen); LHFPL2:  Homo sapiens  lipoma HMG1C fusion partner-like 2 (LHFPL2), mRNA; ITGAX: Integrin alpha-X precursor (Leukocyte adhesion glycoprotein p150,95 alpha chain) (Leukocyte adhesion receptor p150,95) (CD11c) (Leu M5); LOC389142: hypothetical LOC389142; PLXNC1:  Homo sapiens  plexin C1 (PLXNC1), mRNA; SLA: SRC-like-adapter (Src-like-adapter protein 1) (hSLAP); ELL: RNA polymerase II elongation factor ELL (Eleven-nineteen lysine-rich leukemia protein); NPY: Neuropeptide Y precursor [Contains: Neuropeptide Y (Neuropeptide tyrosine) (NPY); C-flanking peptide of NPY (CPON)]; IGSF11: Brain and testis-specific immunoglobin superfamily protein; ITPK1:  Homo sapiens  inositol 1,3,4-triphosphate 5/6 kinase (ITPK1), mRNA; ASB1: Ankyrin repeat and SOCS box containing protein 1 (ASB-1); SELB: Selenocysteine-specific elongation factor (Elongation factor sec); LOC131873: hypothetical protein LOC131873; PCCA: Propionyl-CoA carboxylase alpha chain, mitochondrial precursor (EC 6.4.1.3) (PCCase alpha subunit) (Propanoyl-CoA:carbon dioxide ligase alpha subunit); HAPIP: Huntingtin-associated protein-interacting protein (Duo protein); PLAUR: Urokinase plasminogen activator surface receptor precursor (uPAR) (U-PAR) (Monocyte activation antigen Mo3) (CD87 antigen); SIDTI: SIDI transmembrane family, member 1; RPN1: Dolichyl-diphosphooligosaccharide—protein glycosyltransferase 67 kDa subunit precursor (EC 2.4.1.119) (Ribophorin I) (RPN-I); BPAG1: Bullous pemphigoid antigen 1 isofomms 1/2/3/4/5/8 (230 kDa bullous pemphigoid antigen) (BPA) (Hemidesmosomal plaque protein) (Dystonia musculorum protein) (Fragment); ROR2: TYROSINE-PROTEIN KINASE TRANSMEMBRANE RECEPTOR ROR2-PRECURSOR (EC 2.7.1.112) (NEUROTROPHIC TYROSINE KINASE, RECEPTOR-RELATED 2); MMP12: MACROPHAGE METALLOELASTASE PRECURSOR (EC 3.4.24.65) (HME) (MATRIX METALLOPROTEINASE-12) (MMP-12) (MACROPHAGE ELASTASE) (ME); GAP43: Neuromodulin (Axonal membrane protein GAP-43) (Growth associated protein 43) (PP46) (Neural phosphoprotein B-50); FSTL11: Follistatin-related protein 1 precursor (Follistatin-like 1); MAP4: Microtubule-associated protein 4 (MAP 4); ZNF217: Zinc finger protein 217; ALOX5: ARACHIDONATE 5-LIPOXYGENASE (EC 1.13.11.34) (5-LIPOXYGENASE) (5-LO); NPHP3: nephronophthisis 3; GPNMB: Putative transmembrane protein NMB precursor (Transmembrane glycoprotein HGFIN); SPP1: Osteopontin precursor (Bone sialoprotein 1) (Urinary stone protein) (Secreted phosphoprotein 1) (SPP-1) (Nephropontin) (Uropontin); ZNF80: Zinc finger protein 80 (ZNFPT17); MGP: Matrix Gla-protein precursor (MGP); C30RF15:; NEK11: NIMA (never in mitosis gene a)—related kinase 11; POLQ: polymerase (DNA directed), theta; ADFP: ADIPOPHILIN (ADIPOSE DIFFERENTIATION-RELATED PROTEIN) (ADRP); UBXD1: UBX domain-containing protein 1; 38413: membrane-associated ring finger (C3HC4) 2; FLJ46299:; ZBTB20: Zinc finger and BTB domain containing protein 20 (Zinc finger protein 288) (Dendritic-derived BTB/POZ zinc finger protein); HLA-DQA2: HLA class II histocompatibility antigen, DQ(6) alpha chain precursor (DX alpha chain) (HLA-DQA1); ZXDC: ZXD family zinc finger C; GRN: Granulins precursor (Acrogranin) (Proepithelin) (PEPI) [Contains: Paragranulin; Granulin 1 (Granulin G); Granulin 2 (Granulin F); Granulin 3 (Granulin B); Granulin 4 (Granulin A); Granulin 5 (Granulin C); Granulin 6 (Granulin D); Granulin 7 (Granulin E)]; PSCD1: CYTOHESIN 1 (SEC7 HOMOLOG B2-1).; GYS1: Glycogen [starch] synthase, muscle (EC 2.4.1.11); C14ORF132: NA; CD80: T lymphocyte activation antigen CD80 precursor (Activation B7-1 antigen) (CTLA-4 counter-receptor B7.1) (B7) (BB1); CDGAP: Cdc42 GTPase-activating protein; LMOD1: Leiomodin 1 (Leiomodin, muscle form) (64 kDa autoantigen D1) (64 kDa autoantigen 1D) (64 kDa autoantigen 1D3) (Thyroid-associated opthalmopathy autoantigen) (Smooth muscle leiomodin) (SM-Lmod); SLC41A3: solute carrier family 41, member 3; HOXD1: Homeobox protein Hox-D1; STAT5A: SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 5A; OPRM1: Mu-type opioid receptor (MOR-1); ITPR2: INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2 (TYPE 2 INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR) (TYPE 2 INSP3 RECEPTOR) (IP3 RECEPTOR ISOFORM 2) (INSP3R2); HIF1A: HYPOXIA-INDUCIBLE FACTOR 1 ALPHA (HIF-1 ALPHA) (ARNT INTERACTING PROTEIN) (MEMBER OF PAS PROTEIN 1) (MOP1) (HIF1 ALPHA); PKD2: Polycystin 2 (Autosomal dominant polycystic kidney disease type II protein) (Polycystwin) (R48321); STEAP: Six transmembrane epithelial antigen of prostate; AGTR1: Type-1 angiotensin II receptor (AT1) (AT1AR); NDUFB4: NADH dehydrogenase (ubiquinone) 1 beta subcomplex; GLRA3: Glycine receptor alpha-3 chain precursor; MEF2A: Myocyte-specific enhancer factor 2A (Serum response factor-like protein 1); STX3BP5L: syntaxin binding protein 5-like; APOBEC3D: NA; FMNL1: FORMIN-LIKE PROTEIN (PROTEIN C17ORF1); PLXND1:  Homo sapiens  plexin D1 (PLXND1), mRNA; ATP2C1: Calcium-transporting ATPase type 2C, member 1 (ATPase 2Cl) (ATP-dependent Ca(2+) pump PMR1); RUVBL1: RuvB-like 1 (EC 3.6.1.-) (49-kDa TATA box-binding protein-interacting protein) (49 kDa TBP-interacting protein) (TIP49a) (Pontin 52) (Nuclear matrix protein 238) (NMP 238) (54 kDa erythrocyte cytosolic protein) (ECP-54) (TIP60-associated protein 54-alpha) (TAP54-alpha); CASR: Extracellular calcium-sensing receptor precursor (CaSR) (Parathyroid Cell calcium-sensing receptor); PTPRR: PROTEIN-TYROSINE PHOSPHATASE R PRECURSOR (EC 3.1.3.48) (PROTEIN-TYROSINE PHOSPHATASE PCPTP1) (NC-PTPCOM1) (CH-1PTPASE); SMPDL3A: Acid sphingomyelinase-like phosphodiesterase 3a precursor (EC 3.1.4.-) (ASM-like phosphodiesterase 3a); APOD: Apolipoprotein D precursor (Apo-D) (ApoD); APG3L: APG3 autophagy 3-like ( S. cerevisiae ); FLJ35880: FLJ35880: hypothetical protein FLJ35880; TMCCl: transmembrane and coiled-coil domains 1; CD96: T-cell surface protein tactile precursor (CD96 antigen); C1QB: Complement Clq subcomponent, B chain precursor; CTSD: Cathepsin D precursor (EC 3.4.23.5); FLI1: FRIEND LEUKEMIA INTEGRATION 1 TRANSCRIPTION FACTOR (FLI-1 PROTO-ONCOGENE) (ERGB TRANSCRIPTION FACTOR).; MMP9: 92 kDa type IV collagenase precursor (EC 3.4.24.35) (92 kDa gelatinase) (Matrix metalloproteinase-9) (MMP-9) (Gelatinase B) (GELB); TCIRG1: Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3 (V-ATPase 116-kDa isoform a3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 KDa) (OC116) (T-cell immune regulator 1) (T cell immune response cDNA7 protein) (TIRC7); ITGB5: Integrin beta-5 precursor; FLJ25414: NA; NR1H3: OXYSTEROLS RECEPTOR LXR-ALPHA (LIVER X RECEPTOR ALPHA) (NUCLEAR ORPHAN RECEPTOR LXR-ALPHA).; HSPBAP1: HSPB (eat shock 27 kDa) associated protein 1; APOC1: Apolipoprotein C-1 precursor (Apo-CI); THPO: Thrombopoietin precursor (Megakaryocyte colony stimulating factor) (Myeloproliferative leukemia virus oncogene ligand) (C-mpl ligand) (ML) (Megakaryocyte growth and development factor) (MGDF); FTL: Ferritin light chain (Ferritin L subunit); HADHSC: Short chain 3-hydroxyacyl-CoA dehydrogenase, mitochondrial precursor (EC 1.1.1.35) (HCDH) (Medium and short chain L-3-hydroxyacyl-coenzyme A dehydrogenase); ALOX5AP: 5-lipoxygenase activating protein (FLAP) (MK-886-binding protein); LAIR1:  Homo sapiens  leukocyte-associated Ig-like receptor 1 (LAIR1), transcript variant a, mRNA; UPP1: Uridine phosphorylase 1 (EC 2.4.2.3) (UrdPase 1) (UPase 1); LAPTM5: Lysosomal-associated multitransmembrane protein (Retinoic acid-inducible E3 protein) (HA 1520); CSTA: cystatin A (stefin A); ADCY5: adenylate cyclase 5; PHLDB2: pleckstrin homology-like domain, family B, member 2; LL5 beta [ Homo sapiens ]; GM2A: Ganglioside GM2 activator precursor (GM2-AP) (Cerebroside sulfate activator protein) (Shingolipid activator protein 3) (SAP-3); NUDT16: nudix-type motif 16; ACSL1: Long-chain-fatty-acid—CoA ligase 1 (EC 6.2.1.3) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Palmitoyl-CoA ligase 1) (Long-chain fatty acid CoA ligase 2) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Acyl-CoA synthetase 1) (ACS1) (Palmitoyl-CoA ligase 2); VAMP5: Vesicule-associated membrane protein 5 (VAMP-5) (Myobrevin) (HSPC191); ACP2: LYSOSOMAL ACID PHOSPHATASE PRECURSOR (EC 3.1.3.2) (LAP); HLA-DPA1: HLA class II histocompatibility antigen, DP alpha chain precursor (HLA-SB alpha chain) (MHC class II DP3-alpha) (DP(W3)) (DP(W4)); TUBA3: tubulin, alpha 3; MMP7: MATRILYSIN PRECURSOR (EC 3.4.24.23) (PUMP-1 PROTEASE) (UTERINE METALLOPROTEINASE) (MATRIX METALLOPROTEINASE-7) (MMP-7) (MATRIN); H41: hypothetical protein H41; NR12: nuclear receptor subfamily 1, group 1, member 2; FGFR2: FIBROBLAST GROWTH FACTOR RECEPTOR 2 PRECURSOR (EC 2.7.1.112) (FGFR-2) (KERATINOCYTE GROWTH FACTOR RECEPTOR 2).; GBA: Glucosylceramidase precursor (EC 3.2.1.45) (Beta-glucocerebrosidase) (Acid beta-glucosidase) (D-glucosyl-N-acylsphingosine glucohydrolase) (Alglucerase) (Imiglucerase); CHAF1A: Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor 1 p150 subunit) (CAF-1 150 kDa subunit) (CAF-1p150); GSK3B: glycogen synthase kinase 3 beta; DOCK2: Dedicator of cytokinesis protein 2; URB: steroid sensitive gene 1; HCLS1: Hematopoietic lineage cell specific protein (Hematopoietic cell-specific LYN substrate 1) (LCKBP1); CD200R1: CD200 receptor 1; SLCO2B1: SOLUTE CARRIER FAMILY 21 MEMBER 9 (ORGANIC ANION TRANSPORTER B) (OATP-B) (ORGANIC ANION TRANSPORTER POLYPEPTIDE-RELATED PROTEIN 2) (OATP-RP2) (OATPRP2); B4GALT4: Beta-1,4-galactosyltransferase 4 (EC 2.4.1.-) (b4Gal-T4) [Includes: N-acetyllactosamine synthase (EC 2.4.1.90) (NaI synthetase); Beta-N-acetylglucosaminyl-glycolipid beta-1,4 galactosyltransferase (EC 2.4.1.-)]; PLCXD2: phosphatidylinositol-specific phospholipase C, X domain containing 2; FABP7: Fatty acid-binding protein, brain (B-FABP) (Brain lipid-binding protein) (BLBP) (Mammary derived growth inhibitor related); CAMKK2:  Homo sapiens  calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2), transcript variant 1, mRNA; FCGR1A: High affinity immunoglobulin gamma Fc receptor I precursor (Fc-gamma R1) (FcRI) (IgG Fc receptor I) (CD64 antigen); SELL: L-selectin precursor (Lymph node homing receptor) (Leukocyte adhesion molecule-1) (LAM-1) (Leukocyte surface antigen Leu-8) (TQ1) (gp90-MEL) (Leukocyte-endothelial cell adhesion molecule 1) (LECAM1) (CD62L); SELE:  Homo sapiens  selectin E (endothelial adhesion molecule 1) (SELE), mRNA; HNRPM: Heterogeneous nuclear ribonucleoprotein M (hnRNP M); MGC45840: hypothetical protein MGC45840; F5: Coagulation factor V precursor (Activated protein C cofactor); SMTN: Smoothelin; RA13:  Homo sapiens  retinoic acid induced 3 (RA13), mRNA; HLA-DRA: HLA class II histocompatibility antigen, DR alpha chain precursor (MHC class II antigen DRA); CSTB: Cystatin B (Liver thiol proteinase inhibitor) (CPI-B) (Stefin B); FLJ12592: N/A; TAGLN3: Neuronal protein NP25 (Neuronal protein 22) (NP22). 
     Example 2 
     Methods for Genotyping of the Cathgen Samples and Statistical Analysis Early Onset CAD Case Control Sample (CATHGEN) 
     CATHGEN subjects were recruited sequentially through the cardiac catheterization laboratories at Duke University Hospital (Durham, N.C.) with approval from the Duke Institutional Review Board. All subjects undergoing catheterization were offered participation in the study and signed informed consent. Medical history and clinical data were collected and stored in the Duke Information System for Cardiovascular Care database maintained at the Duke Clinical Research Institute [1]. 
     Controls and cases were chosen on the basis of extent of coronary artery disease as measured by the CAD index (CADi). CADi is a numerical summary of coronary angiographic data that incorporates the extent and anatomical distribution of coronary disease [2]. CADi has been shown to be a better predictor of clinical outcome than the extent of CAD [3]. Affected status was determined by the presence of significant CAD defined as a CADi≧32 [4]. For patients older than 55 years of age, a higher CADi threshold (CADi≧74) was used to adjust for the higher baseline extent of CAD in this group. Medical records were reviewed to determine the age-of-onset (AOO) of CAD, i.e. the age at first documented surgical or percutaneous coronary revascularization procedure, myocardial infarction (MI), or cardiac catheterization meeting the above defined CADi thresholds. The CATHGEN cases were stratified into a young affected group (AOO ≦55 years), which provides a consistent comparison group for the GENECARD family study. Controls were defined as subjects ≧60 years of age, with no CAD as demonstrated by coronary angiography and no documented history of cerebrovascular or peripheral vascular 
     A set of at least 5 SNPs with a minor allele frequency (MAF) of &gt;10% [5] was selected for genotyping in each gene CATHOEN samples using the SNPselector program [6]. Genomic DNA for CATHGEN samples was extracted from whole blood using the PureGene system (Gentra Systems, Minneapolis, Minn.). Genotyping was performed using the ABI 7900HT Taqman SNP genotyping system (Applied Biosystems, Foster City, Calif.), which incorporates a standard PCR-based, dual fluor, allelic discrimination assay in 384 well plate format with a dual laser scanner. Allelic discrimination assays were purchased through Applied Biosystems or, in cases in which the assays were not available, primer and probe sets were designed and purchased through Integrated DNA Technologies (IDT, Coralville, Iowa). A total of 15 quality control samples, composed of 6 reference genotype controls in duplicate, two Centre d&#39;Etude du Polymorphisme Humain (CEPH) pedigree individuals and one no-template sample, were included in each quadrant of the 384 well plate. Genotyping was also performed using the Illumina BeadStation 500G SNP genotyping system (Illumina, San Diego, Calif.). Each Sentrix Array generates 1536 genotypes for 96 individuals; within each individual array experiment four quality control samples were included, two CEPH pedigree individuals and two identical in-plate controls. Results of the CEPH and quality control samples were compared to identify possible sample plating errors and genotype calling inconsistencies. SNPs that showed mismatches on quality control samples were reviewed by an independent genotyping supervisor for potential genotyping errors. All SNPs examined were successfully genotyped for 95% or more of the individuals in the study. Error rate estimates for SNPs meeting the quality control benchmarks were determined to be less than 0.2%. 
     All SNPs were tested for deviations from Hardy-Weinberg equilibrium (HWE) in the affected and unaffected race stratified groups. No such deviations were observed. 
     Additionally, linkage disequilibrium between pairs of SNPs was assessed using the Graphical Overview of Linkage Disequilibrium (GOLD) package [7] and displayed using Haploview[8]. Allelic association in CATHGEN was examined using multivariable logistic regression modeling adjusted for race and sex, and also for race, sex, and known CAD risk factors (history of hypertension, history of diabetes mellitus, body mass index, history of dyslipidemia, and smoking history) as covariates. These adjustments could hypothetically allow us to control for competing genetic pathways that are independent risk factors for CAD, therefore allowing us to detect a separate CAD genetic effect. SAS 9.1 (SAS Institute, Cary, N.C.) was used for statistical analysis. The haplo.stats package was used to identify and test for association of haplotypes in CATHGEN. Haplo.stats expands on the likelihood approach to account for ambiguity in case-control studies by using a generalized linear model (GLM) to test for haplotype association which allows for adjustment of non-genetic covariates [9]. This method derives a score statistic to test the null hypothesis of no association of the trait with the genotype. In addition to the global statistic, haplo.stats computes score statistics for the components of the genetic vectors, such as individual haplotypes. 
     Results from these experiments are shown in Tables 3-5. The SNP represented by SEQ ID NO:188 contains a five-base pair deletion relative to the wild-type sequence. As used herein, the term SNP also includes this polymorphism having the five-nucleotide deletion. “RK” indicates rank in predicting CAD, with the most predictive genes having a lower number; “CH” indicates the chromosome in which the gene locus resides in the human genome. 
     
       
         
           
               
               
               
               
               
               
               
               
             
               
                 TABLE 3 
               
               
                   
               
               
                   
                   
                   
                   
                   
                   
                 SEQ ID 
                 SEQ ID 
               
               
                 RK 
                 CH 
                 LOCUS 
                 GENBANK 
                 PROBE 
                 NCB135 
                 (SNP) 
                 (WT) 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 15 
                 1 
                 HSPG2 
                 NM_005529 
                 RS4654773 
                 21,997,568 
                 1 
                 576 
               
               
                 15 
                 1 
                 HSPG2 
                 NM_005529 
                 RS17467346 
                 22,005,318 
                 2 
                 577 
               
               
                 15 
                 1 
                 HSPG2 
                 NM_005529 
                 RS11587857 
                 22,005,614 
                 3 
                 578 
               
               
                 15 
                 1 
                 HSPG2 
                 NM_005529 
                 RS12081298 
                 22,007,531 
                 4 
                 579 
               
               
                 43 
                 1 
                 CDC42 
                 NM_001791 
                 RS2501275 
                 22,120,371 
                 5 
                 580 
               
               
                 43 
                 1 
                 CDC42 
                 NM_001791 
                 RS2473322 
                 22,135,378 
                 6 
                 581 
               
               
                 43 
                 1 
                 CDC42 
                 NM_001791 
                 RS10917139 
                 22,146,844 
                 7 
                 582 
               
               
                 43 
                 1 
                 CDC42 
                 NM_001791 
                 RS2056974 
                 22,154,400 
                 8 
                 583 
               
               
                 71 
                 1 
                 C1QB 
                 NM_000491 
                 RS291989 
                 22,725,205 
                 9 
                 584 
               
               
                 71 
                 1 
                 C1QB 
                 NM_000491 
                 RS291988 
                 22,725,364 
                 10 
                 585 
               
               
                 71 
                 1 
                 C1QB 
                 NM_000491 
                 RS291985 
                 22,726,245 
                 11 
                 586 
               
               
                 71 
                 1 
                 C1QB 
                 NM_000491 
                 RS12756603 
                 22,727,182 
                 12 
                 587 
               
               
                 71 
                 1 
                 C1QB 
                 NM_000491 
                 RS291982 
                 22,727,712 
                 13 
                 588 
               
               
                 71 
                 1 
                 C1QB 
                 NM_000491 
                 RS631090 
                 22,731,709 
                 14 
                 589 
               
               
                 71 
                 1 
                 C1QB 
                 NM_000491 
                 RS623607 
                 22,732,022 
                 15 
                 590 
               
               
                 71 
                 1 
                 C1QB 
                 NM_000491 
                 RS10580 
                 22,733,264 
                 16 
                 591 
               
               
                 71 
                 1 
                 C1QB 
                 NM_000491 
                 RS292007 
                 22,736,818 
                 17 
                 592 
               
               
                 4 
                 1 
                 AIM1L 
                 AK095339 
                 RS7416513 
                 26,332,091 
                 18 
                 593 
               
               
                 4 
                 1 
                 AIM1L 
                 AK095339 
                 RS17163868 
                 26,332,523 
                 19 
                 594 
               
               
                 4 
                 1 
                 AIM1L 
                 AK095339 
                 RS4659371 
                 26,341,703 
                 20 
                 595 
               
               
                 4 
                 1 
                 AIM1L 
                 AK095339 
                 RS4659431 
                 26,342,533 
                 21 
                 596 
               
               
                 4 
                 1 
                 AIM1L 
                 AK095339 
                 RS7517559 
                 26,346,916 
                 22 
                 597 
               
               
                 4 
                 1 
                 AIM1L 
                 AK095339 
                 RS4072445 
                 26,348,361 
                 23 
                 598 
               
               
                 4 
                 1 
                 AIM1L 
                 AK095339 
                 RS11247920 
                 26,349,620 
                 24 
                 599 
               
               
                 4 
                 1 
                 AIM1L 
                 AK095339 
                 RS7535656 
                 26,357,608 
                 25 
                 600 
               
               
                 4 
                 1 
                 AIM1L 
                 AK095339 
                 RS10902742 
                 26,360,399 
                 26 
                 601 
               
               
                 4 
                 1 
                 AIM1L 
                 AK095339 
                 RS4454539 
                 26,364,405 
                 27 
                 602 
               
               
                 4 
                 1 
                 AIM1L 
                 AK095339 
                 RS4233461 
                 26,365,448 
                 28 
                 603 
               
               
                 19 
                 1 
                 C1ORF38 
                 AF044896 
                 RS11247703 
                 27,887,795 
                 29 
                 604 
               
               
                 19 
                 1 
                 C1ORF38 
                 AF044896 
                 RS12048235 
                 27,890,026 
                 30 
                 605 
               
               
                 19 
                 1 
                 C1ORF38 
                 AF044896 
                 RS3766398 
                 27,893,447 
                 31 
                 606 
               
               
                 19 
                 1 
                 C1ORF38 
                 AF044896 
                 RS3766400 
                 27,893,508 
                 32 
                 607 
               
               
                 19 
                 1 
                 C1ORF38 
                 AF044896 
                 RS2236074 
                 27,895,526 
                 33 
                 608 
               
               
                 19 
                 1 
                 C1ORF38 
                 AF044896 
                 RS1467465 
                 27,895,545 
                 34 
                 609 
               
               
                 19 
                 1 
                 C1ORF38 
                 AF044896 
                 RS1467464 
                 27,895,792 
                 35 
                 610 
               
               
                 19 
                 1 
                 C1ORF38 
                 AF044896 
                 RS6564 
                 27,897,117 
                 36 
                 611 
               
               
                 19 
                 1 
                 C1ORF38 
                 AF044896 
                 RS6565 
                 27,897,299 
                 37 
                 612 
               
               
                 58 
                 1 
                 LAPTM5 
                 U51240 
                 RS3795438 
                 30,875,730 
                 38 
                 613 
               
               
                 58 
                 1 
                 LAPTM5 
                 U51240 
                 RS12404920 
                 30,876,050 
                 39 
                 614 
               
               
                 58 
                 1 
                 LAPTM5 
                 U51240 
                 1P0258 
                 30,877,135 
                 40 
                 615 
               
               
                 58 
                 1 
                 LAPTM5 
                 U51240 
                 RS1188356 
                 30,880,175 
                 41 
                 616 
               
               
                 58 
                 1 
                 LAPTM5 
                 U51240 
                 RS1188360 
                 30,881,469 
                 42 
                 617 
               
               
                 58 
                 1 
                 LAPTM5 
                 U51240 
                 RS3748602 
                 30,883,462 
                 43 
                 618 
               
               
                 58 
                 1 
                 LAPTM5 
                 U51240 
                 RS3748603 
                 30,884,064 
                 44 
                 619 
               
               
                 58 
                 1 
                 LAPTMS 
                 U51240 
                 RS1050663 
                 30,884,457 
                 45 
                 620 
               
               
                 58 
                 1 
                 LAPTM5 
                 U51240 
                 RS11585511 
                 30,886,062 
                 46 
                 621 
               
               
                 58 
                 1 
                 LAPTM5 
                 U51240 
                 RS3790495 
                 30,890,608 
                 47 
                 622 
               
               
                 58 
                 1 
                 LAPTM5 
                 U51240 
                 RS3790496 
                 30,891,084 
                 48 
                 623 
               
               
                 58 
                 1 
                 LAPTM5 
                 U51240 
                 RS1188349 
                 30,892,750 
                 49 
                 624 
               
               
                 58 
                 1 
                 LAPTM5 
                 U51240 
                 RS1188347 
                 30,895,433 
                 50 
                 625 
               
               
                 58 
                 1 
                 LAPTM5 
                 U51240 
                 RS3790503 
                 30,898,168 
                 51 
                 626 
               
               
                 58 
                 1 
                 LAPTM5 
                 U51240 
                 RS1407882 
                 30,899,288 
                 52 
                 627 
               
               
                 58 
                 1 
                 LAPTM5 
                 U51240 
                 RS2273979 
                 30,899,761 
                 53 
                 628 
               
               
                 58 
                 1 
                 LAPTM5 
                 U51240 
                 RS11801629 
                 30,900,219 
                 54 
                 629 
               
               
                 45 
                 1 
                 CACNA1E 
                 NM_000721 
                 RS704326 
                 178,491,314 
                 55 
                 630 
               
               
                 72 
                 1 
                 LAMC1 
                 NM_002293 
                 RS4652763 
                 179,725,741 
                 56 
                 631 
               
               
                 72 
                 1 
                 LAMC1 
                 NM_002293 
                 RS12144261 
                 179,745,805 
                 57 
                 632 
               
               
                 72 
                 1 
                 LAMC1 
                 NM_002293 
                 RS10911229 
                 179,782,025 
                 58 
                 633 
               
               
                 72 
                 1 
                 LAMC1 
                 NM_002293 
                 RS2296291 
                 179,811,166 
                 59 
                 634 
               
               
                 72 
                 1 
                 LAMC1 
                 NM_002293 
                 RS7556132 
                 179,817,412 
                 60 
                 635 
               
               
                 72 
                 1 
                 LAMC1 
                 NM_002293 
                 RS7410919 
                 179,826,204 
                 61 
                 636 
               
               
                 72 
                 1 
                 LAMC1 
                 NM_002293 
                 RS20559 
                 179,831,217 
                 62 
                 637 
               
               
                 72 
                 1 
                 LAMC1 
                 NM_002293 
                 RS4651146 
                 179,837,191 
                 63 
                 638 
               
               
                 72 
                 1 
                 LAMC1 
                 NM_002293 
                 RS3738829 
                 179,845,519 
                 64 
                 639 
               
               
                 72 
                 1 
                 LAMC1 
                 NM_002293 
                 RS1547715 
                 179,845,609 
                 65 
                 640 
               
               
                 53 
                 1 
                 CFH 
                 NM_000186 
                 RS529825 
                 193,366,763 
                 66 
                 641 
               
               
                 53 
                 1 
                 CFH 
                 NM_000186 
                 RS800292 
                 193,373,890 
                 67 
                 642 
               
               
                 53 
                 1 
                 CFH 
                 NM_000186 
                 RS1061147 
                 193,385,981 
                 68 
                 643 
               
               
                 53 
                 1 
                 CFH 
                 NM_000186 
                 RS1061170 
                 193,390,894 
                 69 
                 644 
               
               
                 53 
                 1 
                 CFH 
                 NM_000186 
                 RS10801555 
                 193,391,918 
                 70 
                 645 
               
               
                 53 
                 1 
                 CFH 
                 NM_000186 
                 RS2019724 
                 193,406,574 
                 71 
                 646 
               
               
                 53 
                 1 
                 CFH 
                 NM_000186 
                 RS393955 
                 193,424,127 
                 72 
                 647 
               
               
                 53 
                 1 
                 CFH 
                 NM_000186 
                 RS1065489 
                 193,441,431 
                 73 
                 648 
               
               
                 53 
                 1 
                 CFH 
                 NM_000186 
                 RS10801560 
                 193,446,257 
                 74 
                 649 
               
               
                 61 
                 1 
                 LMOD1 
                 X54162 
                 RS6427922 
                 198,587,069 
                 75 
                 650 
               
               
                 61 
                 1 
                 LMOD1 
                 X54162 
                 RS4987074 
                 198,597,289 
                 76 
                 651 
               
               
                 61 
                 1 
                 LMOD1 
                 X54162 
                 RS3738289 
                 198,599,726 
                 77 
                 652 
               
               
                 61 
                 1 
                 LMOD1 
                 X54162 
                 RS2820312 
                 198,600,914 
                 78 
                 653 
               
               
                 61 
                 1 
                 LMOD1 
                 X54162 
                 RS2820315 
                 198,603,921 
                 79 
                 654 
               
               
                 61 
                 1 
                 LMOD1 
                 X54162 
                 RS7528681 
                 198,606,369 
                 80 
                 655 
               
               
                 61 
                 1 
                 LMOD1 
                 X54162 
                 RS2644121 
                 198,612,941 
                 81 
                 656 
               
               
                 61 
                 1 
                 LMOD1 
                 X54162 
                 RS2819346 
                 198,613,744 
                 82 
                 657 
               
               
                 61 
                 1 
                 LMOD1 
                 X54162 
                 RS10800796 
                 198,617,854 
                 83 
                 658 
               
               
                 61 
                 1 
                 LMOD1 
                 X54162 
                 RS2360545 
                 198,623,599 
                 84 
                 659 
               
               
                 61 
                 1 
                 LMOD1 
                 X54162 
                 RS9787358 
                 198,629,327 
                 85 
                 660 
               
               
                 61 
                 1 
                 LMOD1 
                 X54162 
                 RS2819366 
                 198,639,638 
                 86 
                 661 
               
               
                 25 
                 2 
                 CAPG 
                 M94345 
                 RS11678506 
                 85,529,829 
                 87 
                 662 
               
               
                 25 
                 2 
                 CAPG 
                 M94345 
                 RS2271627 
                 85,533,717 
                 88 
                 663 
               
               
                 25 
                 2 
                 CAPG 
                 M94345 
                 RS11690650 
                 85,533,975 
                 89 
                 664 
               
               
                 25 
                 2 
                 CAPG 
                 M94345 
                 RS11539100 
                 85,536,880 
                 90 
                 665 
               
               
                 25 
                 2 
                 CAPG 
                 M94345 
                 RS11687035 
                 85,537,097 
                 91 
                 666 
               
               
                 25 
                 2 
                 CAPG 
                 M94345 
                 RS2271625 
                 85,537,171 
                 92 
                 667 
               
               
                 25 
                 2 
                 CAPG 
                 M94345 
                 RS11539103 
                 85,537,991 
                 93 
                 668 
               
               
                 25 
                 2 
                 CAPG 
                 M94345 
                 RS2002444 
                 85,540,214 
                 94 
                 669 
               
               
                 25 
                 2 
                 CAPG 
                 M94345 
                 RS2229669 
                 85,540,403 
                 95 
                 670 
               
               
                 25 
                 2 
                 CAPG 
                 M94345 
                 RS2229668 
                 85,540,641 
                 96 
                 671 
               
               
                 25 
                 2 
                 CAPG 
                 M94345 
                 RS13020378 
                 85,544,600 
                 97 
                 672 
               
               
                 25 
                 2 
                 CAPG 
                 M94345 
                 RS11696093 
                 85,547,853 
                 98 
                 673 
               
               
                 25 
                 2 
                 CAPG 
                 M94345 
                 RS3770102 
                 85,549,495 
                 99 
                 674 
               
               
                 25 
                 2 
                 CAPG 
                 M94345 
                 RS11682055 
                 85,549,981 
                 100 
                 675 
               
               
                 25 
                 2 
                 CAPG 
                 M94345 
                 RS1877954 
                 85,565,957 
                 101 
                 676 
               
               
                 25 
                 2 
                 CAPG 
                 M94345 
                 RS1877955 
                 85,566,184 
                 102 
                 677 
               
               
                 42 
                 2 
                 VAMP8 
                 NM_003761 
                 RS17508727 
                 85,711,434 
                 103 
                 678 
               
               
                 42 
                 2 
                 VAMP8 
                 NM_003761 
                 RS13426038 
                 85,715,056 
                 104 
                 679 
               
               
                 42 
                 2 
                 VAMP8 
                 NM_003761 
                 RS3770098 
                 85,717,025 
                 105 
                 680 
               
               
                 42 
                 2 
                 VAMP8 
                 NM_003761 
                 RS3731828 
                 85,717,924 
                 106 
                 681 
               
               
                 42 
                 2 
                 VAMP8 
                 NM_003761 
                 RS1009 
                 85,720,395 
                 107 
                 682 
               
               
                 42 
                 2 
                 VAMP8 
                 NM_003761 
                 RS1010 
                 85,720,640 
                 108 
                 683 
               
               
                 50 
                 2 
                 VAMP5 
                 N90862 
                 RS1561198 
                 85,721,647 
                 109 
                 684 
               
               
                 50 
                 2 
                 VAMP5 
                 N90862 
                 RS1254901 
                 85,722,887 
                 110 
                 685 
               
               
                 50 
                 2 
                 VAMP5 
                 N90862 
                 RS12714147 
                 85,725,492 
                 111 
                 686 
               
               
                 50 
                 2 
                 VAMP5 
                 N90862 
                 RS10206961 
                 85,726,642 
                 112 
                 687 
               
               
                 50 
                 2 
                 VAMP5 
                 N90862 
                 RS1254900 
                 85,727,992 
                 113 
                 688 
               
               
                 50 
                 2 
                 VAMP5 
                 N90862 
                 RS719023 
                 85,730,146 
                 114 
                 689 
               
               
                 50 
                 2 
                 VAMP5 
                 N90862 
                 RS2289976 
                 85,730,455 
                 115 
                 690 
               
               
                 50 
                 2 
                 VAMP5 
                 N90862 
                 RS14976 
                 85,730,544 
                 116 
                 691 
               
               
                 50 
                 2 
                 VAMP5 
                 N90862 
                 RS14242 
                 85,732,070 
                 117 
                 692 
               
               
                 2 
                 2 
                 LOC51255 
                 NM_016494 
                 RS2232739 
                 85,734,340 
                 118 
                 693 
               
               
                 2 
                 2 
                 LOC51255 
                 NM_016494 
                 RS2232745 
                 85,735,290 
                 119 
                 694 
               
               
                 2 
                 2 
                 LOC51255 
                 NM_016494 
                 RS6643 
                 85,735,909 
                 120 
                 695 
               
               
                 66 
                 2 
                 HOXD1 
                 AW001001 
                 RS1562315 
                 176,870,989 
                 121 
                 696 
               
               
                 66 
                 2 
                 HOXD1 
                 AW001001 
                 RS1446575 
                 176,873,308 
                 122 
                 697 
               
               
                 66 
                 2 
                 HOXD1 
                 AW001001 
                 RS13390503 
                 176,879,561 
                 123 
                 698 
               
               
                 66 
                 2 
                 HOXD1 
                 AW001001 
                 RS13390932 
                 176,879,918 
                 124 
                 699 
               
               
                 66 
                 2 
                 HOXD1 
                 AW001001 
                 RS6710142 
                 176,880,276 
                 125 
                 700 
               
               
                 66 
                 2 
                 HOXD1 
                 AW001001 
                 RS6725515 
                 176,880,600 
                 126 
                 701 
               
               
                 66 
                 2 
                 HOXD1 
                 AW001001 
                 RS11551009 
                 176,880,885 
                 127 
                 702 
               
               
                 66 
                 2 
                 HOXD1 
                 AW001001 
                 RS1374326 
                 176,883,823 
                 128 
                 703 
               
               
                 66 
                 2 
                 HOXD1 
                 AW001001 
                 RS1026032 
                 176,890,330 
                 129 
                 704 
               
               
                 36 
                 3 
                 RHOA 
                 NM_001664 
                 RS8179164 
                 49,372,288 
                 130 
                 705 
               
               
                 36 
                 3 
                 RHOA 
                 NM_001664 
                 RS974495 
                 49,375,486 
                 131 
                 706 
               
               
                 36 
                 3 
                 RHOA 
                 NM_001664 
                 RS7621003 
                 49,386,408 
                 132 
                 707 
               
               
                 36 
                 3 
                 RHOA 
                 NM_001664 
                 RS7631908 
                 49,400,711 
                 133 
                 708 
               
               
                 36 
                 3 
                 RHOA 
                 NM_001664 
                 RS4855877 
                 49,423,531 
                 134 
                 709 
               
               
                 46 
                 3 
                 FLJ39873 
                 NM_173799 
                 RS1316642 
                 115,506,753 
                 135 
                 710 
               
               
                 24 
                 3 
                 IGSF11 
                 NM_152538 
                 RS1521299 
                 120,093,419 
                 136 
                 711 
               
               
                 24 
                 3 
                 IGSF11 
                 NM_152538 
                 RS4687959 
                 120,106,104 
                 137 
                 712 
               
               
                 24 
                 3 
                 IGSF11 
                 NM_152538 
                 RS6782002 
                 120,107,321 
                 138 
                 713 
               
               
                 24 
                 3 
                 IGSF11 
                 NM_152538 
                 RS1468738 
                 120,114,311 
                 139 
                 714 
               
               
                 24 
                 3 
                 IGSF11 
                 NM_152538 
                 RS2160052 
                 120,124,569 
                 140 
                 715 
               
               
                 24 
                 3 
                 IGSF11 
                 NM_152538 
                 RS2192365 
                 120,126,099 
                 141 
                 716 
               
               
                 24 
                 3 
                 IGSF11 
                 NM_152538 
                 RS2903250 
                 120,131,750 
                 142 
                 717 
               
               
                 24 
                 3 
                 IGSF11 
                 NM_152538 
                 RS9837571 
                 120,138,354 
                 143 
                 718 
               
               
                 24 
                 3 
                 IGSF11 
                 NM_152538 
                 RS39688 
                 120,225,538 
                 144 
                 719 
               
               
                 24 
                 3 
                 IGSF11 
                 NM_152538 
                 RS35859 
                 120,233,743 
                 145 
                 720 
               
               
                 24 
                 3 
                 IGSF11 
                 NM_152538 
                 RS1347448 
                 120,305,831 
                 146 
                 721 
               
               
                 68 
                 3 
                 CD80 
                 NM_005191 
                 HCV387937 
                 120,727,283 
                 147 
                 722 
               
               
                 68 
                 3 
                 CD80 
                 NM_005191 
                 RS1523311 
                 120,730,991 
                 148 
                 723 
               
               
                 68 
                 3 
                 CD80 
                 NM_005191 
                 RS2049502 
                 120,737,075 
                 149 
                 724 
               
               
                 68 
                 3 
                 CD80 
                 NM_005191 
                 RS626364 
                 120,755,573 
                 150 
                 725 
               
               
                 54 
                 3 
                 FSTL1 
                 NM_007085 
                 RS1621291 
                 121,588,392 
                 151 
                 726 
               
               
                 54 
                 3 
                 FSTL1 
                 NM_007085 
                 RS2488 
                 121,595,976 
                 152 
                 727 
               
               
                 54 
                 3 
                 FSTL1 
                 NM_007085 
                 RS1057231 
                 121,596,093 
                 153 
                 728 
               
               
                 54 
                 3 
                 FSTL1 
                 NM_007085 
                 RS13709 
                 121,596,818 
                 154 
                 729 
               
               
                 54 
                 3 
                 FSTL1 
                 NM_007085 
                 RS1700 
                 121,597,327 
                 155 
                 730 
               
               
                 54 
                 3 
                 FSTL1 
                 NM_007085 
                 RS1147696 
                 121,602,169 
                 156 
                 731 
               
               
                 54 
                 3 
                 FSTL1 
                 NM_007085 
                 RS1147704 
                 121,610,461 
                 157 
                 732 
               
               
                 54 
                 3 
                 FSTL1 
                 NM_007085 
                 RS1515577 
                 121,611,630 
                 158 
                 733 
               
               
                 54 
                 3 
                 FSTL1 
                 NM_007085 
                 RS13097755 
                 121,614,452 
                 159 
                 734 
               
               
                 54 
                 3 
                 FSTL1 
                 NM_007085 
                 RS2272515 
                 121,617,573 
                 160 
                 735 
               
               
                 54 
                 3 
                 FSTL1 
                 NM_007085 
                 RS1733306 
                 121,638,524 
                 161 
                 736 
               
               
                 54 
                 3 
                 FSTL1 
                 NM_007085 
                 RS1123897 
                 121,639,724 
                 162 
                 737 
               
               
                 54 
                 3 
                 FSTL1 
                 NM_007085 
                 RS1123898 
                 121,639,772 
                 163 
                 738 
               
               
                 54 
                 3 
                 FSTL1 
                 NM_007085 
                 RS1259333 
                 121,646,977 
                 164 
                 739 
               
               
                 54 
                 3 
                 FSTL1 
                 NM_007085 
                 RS1147707 
                 121,651,938 
                 165 
                 740 
               
               
                 54 
                 3 
                 FSTL1 
                 NM_007085 
                 RS1147709 
                 121,654,410 
                 166 
                 741 
               
               
                 49 
                 3 
                 NDUFB4 
                 NM_004547 
                 RS17140284 
                 121,797,081 
                 167 
                 742 
               
               
                 20 
                 3 
                 PARP9 
                 NM_031458 
                 RS3817040 
                 123,737,459 
                 168 
                 743 
               
               
                 20 
                 3 
                 PARP9 
                 NM_031458 
                 RS7631465 
                 123,754,360 
                 169 
                 744 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS9422 
                 124,815,030 
                 170 
                 745 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS860224 
                 124,820,104 
                 171 
                 746 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS820447 
                 124,830,869 
                 172 
                 747 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS820463 
                 124,839,727 
                 173 
                 748 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS1254392 
                 124,850,703 
                 174 
                 749 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS820325 
                 124,868,367 
                 175 
                 750 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS820371 
                 124,887,401 
                 176 
                 751 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS11717814 
                 124,891,241 
                 177 
                 752 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS40305 
                 124,894,279 
                 178 
                 753 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS820335 
                 124,898,204 
                 179 
                 754 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS820336 
                 124,898,471 
                 180 
                 755 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS3732487 
                 124,902,263 
                 181 
                 756 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS3732485 
                 124,902,472 
                 182 
                 757 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS7641248 
                 124,909,674 
                 183 
                 758 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS820329 
                 124,927,474 
                 184 
                 759 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS4678047 
                 124,935,528 
                 185 
                 760 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS3796164 
                 124,935,751 
                 186 
                 761 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS9840993 
                 124,940,583 
                 187 
                 762 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS3085179 
                 124,941,793 
                 188 
                 763 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS11718105 
                 124,946,398 
                 189 
                 764 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS11707609 
                 124,986,114 
                 190 
                 765 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS7639329 
                 124,993,625 
                 191 
                 766 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS28497577 
                 124,995,317 
                 192 
                 767 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS9846863 
                 124,996,168 
                 193 
                 768 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS4678060 
                 124,998,930 
                 194 
                 769 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS11714297 
                 125,002,269 
                 195 
                 770 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS9816400 
                 125,006,336 
                 196 
                 771 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS2124508 
                 125,009,601 
                 197 
                 772 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS10934651 
                 125,015,899 
                 198 
                 773 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS16834774 
                 125,017,283 
                 199 
                 774 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS13094938 
                 125,017,560 
                 200 
                 775 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS9289225 
                 125,018,733 
                 201 
                 776 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS7652269 
                 125,018,872 
                 202 
                 777 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS3911406 
                 125,021,533 
                 203 
                 778 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS9829784 
                 125,022,826 
                 204 
                 779 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 HCV1602689 
                 125,024,094 
                 205 
                 780 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS2682215 
                 125,027,266 
                 206 
                 781 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS2605417 
                 125,032,085 
                 207 
                 782 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS2700358 
                 125,039,169 
                 208 
                 783 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS2682239 
                 125,042,419 
                 209 
                 784 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS7628376 
                 125,045,246 
                 210 
                 785 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS4461370 
                 125,048,862 
                 211 
                 786 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS1343700 
                 125,054,444 
                 212 
                 787 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS16834817 
                 125,060,723 
                 213 
                 788 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS12495918 
                 125,065,904 
                 214 
                 789 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS2682218 
                 125,066,569 
                 215 
                 790 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS4118366 
                 125,066,921 
                 216 
                 791 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS16834826 
                 125,067,178 
                 217 
                 792 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS13096686 
                 125,072,942 
                 218 
                 793 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS2700408 
                 125,078,122 
                 219 
                 794 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS2682229 
                 125,084,440 
                 220 
                 795 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS2700410 
                 125,085,087 
                 221 
                 796 
               
               
                 16 
                 3 
                 MYLK 
                 NM_053027 
                 RS1920221 
                 125,089,642 
                 222 
                 797 
               
               
                 6 
                 3 
                 OR7E29P 
                 NG_004130 
                 RS2979310 
                 126,871,199 
                 223 
                 798 
               
               
                 23 
                 3 
                 KLF15 
                 NM_014079 
                 RS7622890 
                 127,540,380 
                 224 
                 799 
               
               
                 23 
                 3 
                 KLF15 
                 NM_014079 
                 RS938390 
                 127,541,247 
                 225 
                 800 
               
               
                 23 
                 3 
                 KLF15 
                 NM_014079 
                 RS938389 
                 127,541,460 
                 226 
                 801 
               
               
                 23 
                 3 
                 KLF15 
                 NM_014079 
                 RS7615776 
                 127,543,315 
                 227 
                 802 
               
               
                 23 
                 3 
                 KLF15 
                 NM_014079 
                 RS9838915 
                 127,548,918 
                 228 
                 803 
               
               
                 23 
                 3 
                 KLF15 
                 NM_014079 
                 RS9850626 
                 127,551,477 
                 229 
                 804 
               
               
                 23 
                 3 
                 KLF15 
                 NM_014079 
                 RS6764427 
                 127,552,824 
                 230 
                 805 
               
               
                 23 
                 3 
                 KLF15 
                 NM_014079 
                 RS1358087 
                 127,561,588 
                 231 
                 806 
               
               
                 23 
                 3 
                 KLF15 
                 NM_014079 
                 RS7636709 
                 127,562,692 
                 232 
                 807 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 RS2713594 
                 129,679,198 
                 233 
                 808 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 RS2713579 
                 129,680,802 
                 234 
                 809 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 3P0457 
                 129,681,678 
                 235 
                 810 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 3P0456 
                 129,681,863 
                 236 
                 811 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 3P0448 
                 129,682,014 
                 237 
                 812 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 RS3803 
                 129,682,078 
                 238 
                 813 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 3P0450 
                 129,682,150 
                 239 
                 814 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 RS10934857 
                 129,682,360 
                 240 
                 815 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 3P0455 
                   
                 241 
                 816 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 RS2713604 
                 129,683,157 
                 242 
                 817 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 RS2713603 
                 129,683,232 
                 243 
                 818 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 RS2659689 
                 129,685,704 
                 244 
                 819 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 RS2659691 
                 129,686,398 
                 245 
                 820 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 RS2713601 
                 129,686,434 
                 246 
                 821 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 RS2335052 
                 129,687,649 
                 247 
                 822 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 RS1573858 
                 129,688,558 
                 248 
                 823 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 RS1806462 
                 129,689,316 
                 249 
                 824 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 RS2953120 
                 129,692,180 
                 250 
                 825 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 RS2860228 
                 129,692,365 
                 251 
                 826 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 RS9851497 
                 129,695,224 
                 252 
                 827 
               
               
                 63 
                 3 
                 GATA2 
                 ABC002557 
                 RS6439129 
                 129,695,471 
                 253 
                 828 
               
               
                 52 
                 3 
                 PLXND1 
                 NM_015103 
                 RS2625967 
                 130,749,957 
                 254 
                 829 
               
               
                 52 
                 3 
                 PLXND1 
                 NM_015103 
                 RS2285359 
                 130,764,416 
                 255 
                 830 
               
               
                 52 
                 3 
                 PLXND1 
                 NM_015103 
                 RS2245285 
                 130,769,111 
                 256 
                 831 
               
               
                 52 
                 3 
                 PLXND1 
                 NM_015103 
                 RS2245278 
                 130,769,333 
                 257 
                 832 
               
               
                 52 
                 3 
                 PLXND1 
                 NM_015103 
                 RS2285366 
                 130,772,785 
                 258 
                 833 
               
               
                 52 
                 3 
                 PLXND1 
                 NM_015103 
                 RS2285368 
                 130,774,197 
                 259 
                 834 
               
               
                 52 
                 3 
                 PLXND1 
                 NM_015103 
                 RS2244708 
                 130,774,449 
                 260 
                 835 
               
               
                 52 
                 3 
                 PLXND1 
                 NM_015103 
                 RS2255703 
                 130,775,954 
                 261 
                 836 
               
               
                 52 
                 3 
                 PLXND1 
                 NM_015103 
                 RS1110168 
                 130,779,921 
                 262 
                 837 
               
               
                 52 
                 3 
                 PLXND1 
                 NM_015103 
                 RS10934885 
                 130,781,692 
                 263 
                 838 
               
               
                 52 
                 3 
                 PLXND1 
                 NM_015103 
                 RS2285370 
                 130,785,153 
                 264 
                 839 
               
               
                 52 
                 3 
                 PLXND1 
                 NM_015103 
                 RS2285371 
                 130,785,770 
                 265 
                 840 
               
               
                 52 
                 3 
                 PLXND1 
                 NM_015103 
                 RS2285372 
                 130,787,495 
                 266 
                 841 
               
               
                 52 
                 3 
                 PLXND1 
                 NM_015103 
                 RS2301572 
                 130,788,158 
                 267 
                 842 
               
               
                 52 
                 3 
                 PLXND1 
                 NM_015103 
                 RS2285373 
                 130,790,907 
                 268 
                 843 
               
               
                 52 
                 3 
                 PLXND1 
                 NM_015103 
                 RS4688807 
                 130,791,961 
                 269 
                 844 
               
               
                 22 
                 3 
                 ATP2C1 
                 NM_001001485 
                 RS852216 
                 132,094,968 
                 270 
                 845 
               
               
                 22 
                 3 
                 ATP2C1 
                 NM_001001485 
                 RS2669869 
                 132,100,165 
                 271 
                 846 
               
               
                 22 
                 3 
                 ATP2C1 
                 NM_001001485 
                 RS712984 
                 132,131,496 
                 272 
                 847 
               
               
                 22 
                 3 
                 ATP2C1 
                 NM_001001485 
                 RS852214 
                 132,144,013 
                 273 
                 848 
               
               
                 22 
                 3 
                 ATP2C1 
                 NM_001001485 
                 RS2685193 
                 132,159,002 
                 274 
                 849 
               
               
                 22 
                 3 
                 ATP2C1 
                 NM_001001485 
                 RS218481 
                 132,204,901 
                 275 
                 850 
               
               
                 22 
                 3 
                 ATP2C1 
                 NM_001001485 
                 RS190067 
                 132,213,062 
                 276 
                 851 
               
               
                 41 
                 3 
                 BFSP2 
                 NM_003571 
                 RS517255 
                 134,600,752 
                 277 
                 852 
               
               
                 41 
                 3 
                 BFSP2 
                 NM_003571 
                 RS4854585 
                 134,619,982 
                 278 
                 853 
               
               
                 41 
                 3 
                 BFSP2 
                 NM_003571 
                 RS2276737 
                 134,650,061 
                 279 
                 854 
               
               
                 41 
                 3 
                 BFSP2 
                 NM_003571 
                 RS1881918 
                 134,653,982 
                 280 
                 855 
               
               
                 41 
                 3 
                 BFSP2 
                 NM_003571 
                 RS2737717 
                 134,668,532 
                 281 
                 856 
               
               
                 41 
                 3 
                 BFSP2 
                 NM_003571 
                 RS6439410 
                 134,676,110 
                 282 
                 857 
               
               
                 47 
                 3 
                 AGTR1 
                 D13814 
                 RS2638362 
                 149,903,214 
                 283 
                 858 
               
               
                 47 
                 3 
                 AGTR1 
                 D13814 
                 RS10935724 
                 149,903,951 
                 284 
                 859 
               
               
                 47 
                 3 
                 AGTR1 
                 D13814 
                 RS931490 
                 149,913,465 
                 285 
                 860 
               
               
                 47 
                 3 
                 AGTR1 
                 D13814 
                 RS2640543 
                 149,915,067 
                 286 
                 861 
               
               
                 47 
                 3 
                 AGTR1 
                 D13814 
                 RS718858 
                 149,918,210 
                 287 
                 862 
               
               
                 47 
                 3 
                 AGTR1 
                 D13814 
                 RS909383 
                 149,918,904 
                 288 
                 863 
               
               
                 47 
                 3 
                 AGTR1 
                 D13814 
                 RS3772620 
                 149,919,006 
                 289 
                 864 
               
               
                 47 
                 3 
                 AGTR1 
                 D13814 
                 RS389566 
                 149,929,080 
                 290 
                 865 
               
               
                 47 
                 3 
                 AGTR1 
                 D13814 
                 RS385338 
                 149,931,854 
                 291 
                 866 
               
               
                 47 
                 3 
                 AGTR1 
                 D13814 
                 RS275649 
                 149,936,024 
                 292 
                 867 
               
               
                 47 
                 3 
                 AGTR1 
                 D13814 
                 RS1800766 
                 149,940,340 
                 293 
                 868 
               
               
                 47 
                 3 
                 AGTR1 
                 D13814 
                 RS5182 
                 149,942,093 
                 294 
                 869 
               
               
                 47 
                 3 
                 AGTR1 
                 D13814 
                 RS5188 
                 149,942,917 
                 295 
                 870 
               
               
                 47 
                 3 
                 AGTR1 
                 D13814 
                 RS275645 
                 149,947,152 
                 296 
                 871 
               
               
                 47 
                 3 
                 AGTR1 
                 D13814 
                 RS9849625 
                 150,022,852 
                 297 
                 872 
               
               
                 47 
                 3 
                 AGTR1 
                 D13814 
                 RS3772587 
                 150,059,614 
                 298 
                 873 
               
               
                 33 
                 4 
                 PPARGC1A 
                 NM_013261 
                 RS3774923 
                 23,471,333 
                 299 
                 874 
               
               
                 33 
                 4 
                 PPARGC1A 
                 NM_013261 
                 RS3736265 
                 23,490,976 
                 300 
                 875 
               
               
                 33 
                 4 
                 PPARGC1A 
                 NM_013261 
                 RS8192678 
                 23,491,931 
                 301 
                 876 
               
               
                 33 
                 4 
                 PPARGC1A 
                 NM_013261 
                 RS2290604 
                 23,506,507 
                 302 
                 877 
               
               
                 75 
                 4 
                 HADHSC 
                 X96752 
                 RS221330 
                 109,278,971 
                 303 
                 878 
               
               
                 75 
                 4 
                 HADHSC 
                 X96752 
                 RS3775974 
                 109,283,987 
                 304 
                 879 
               
               
                 75 
                 4 
                 HADHSC 
                 X96752 
                 RS141066 
                 109,289,155 
                 305 
                 880 
               
               
                 75 
                 4 
                 HADHSC 
                 X96752 
                 RS763432 
                 109,289,241 
                 306 
                 881 
               
               
                 75 
                 4 
                 HADHSC 
                 X96752 
                 RS1051519 
                 109,298,336 
                 307 
                 882 
               
               
                 75 
                 4 
                 HADHSC 
                 X96752 
                 RS732940 
                 109,302,674 
                 308 
                 883 
               
               
                 75 
                 4 
                 HADHSC 
                 X96752 
                 RS732941 
                 109,302,708 
                 309 
                 884 
               
               
                 75 
                 4 
                 HADHSC 
                 X96752 
                 RS3796939 
                 109,305,695 
                 310 
                 885 
               
               
                 75 
                 4 
                 HADHSC 
                 X96752 
                 RS221347 
                 109,313,226 
                 311 
                 886 
               
               
                 59 
                 4 
                 GLRA3 
                 U93917 
                 RS4695942 
                 175,942,562 
                 312 
                 887 
               
               
                 59 
                 4 
                 GLRA3 
                 U93917 
                 RS10021195 
                 175,953,446 
                 313 
                 888 
               
               
                 59 
                 4 
                 GLRA3 
                 U93917 
                 RS7438094 
                 175,981,922 
                 314 
                 889 
               
               
                 59 
                 4 
                 GLRA3 
                 U93917 
                 RS2046485 
                 176,034,349 
                 315 
                 890 
               
               
                 11 
                 5 
                 IL7R 
                 NM_002185 
                 RS1389832 
                 35,894,478 
                 316 
                 891 
               
               
                 11 
                 5 
                 IL7R 
                 NM_002185 
                 RS1494558 
                 35,896,825 
                 317 
                 892 
               
               
                 11 
                 5 
                 IL7R 
                 NM_002185 
                 RS1494555 
                 35,906,947 
                 318 
                 893 
               
               
                 11 
                 5 
                 IL7R 
                 NM_902185 
                 RS7737000 
                 35,907,030 
                 319 
                 894 
               
               
                 11 
                 5 
                 IL7R 
                 NM_002185 
                 RS6897932 
                 35,910,332 
                 320 
                 895 
               
               
                 11 
                 5 
                 IL7R 
                 NM_002185 
                 RS987107 
                 35,910,984 
                 321 
                 896 
               
               
                 11 
                 5 
                 IL7R 
                 NM_002185 
                 RS987106 
                 35,911,350 
                 322 
                 897 
               
               
                 11 
                 5 
                 IL7R 
                 NM_002185 
                 RS3194051 
                 35,912,031 
                 323 
                 898 
               
               
                 40 
                 5 
                 LHFPL2 
                 D86961 
                 RS1050674 
                 77,818,845 
                 324 
                 899 
               
               
                 40 
                 5 
                 LHFPL2 
                 D86961 
                 RS2114978 
                 77,851,010 
                 325 
                 900 
               
               
                 40 
                 5 
                 LHFPL2 
                 D86961 
                 RS6872179 
                 77,865,568 
                 326 
                 901 
               
               
                 40 
                 5 
                 LHFPL2 
                 D86961 
                 RS11948997 
                 77,878,660 
                 327 
                 902 
               
               
                 40 
                 5 
                 LHFPL2 
                 D86961 
                 RS1561735 
                 77,901,984 
                 328 
                 903 
               
               
                 21 
                 5 
                 KIAA0194 
                 BC005880 
                 RS4705411 
                 149,411,218 
                 329 
                 904 
               
               
                 73 
                 5 
                 SGCD 
                 NM_000337 
                 RS10064593 
                 155,688,772 
                 330 
                 905 
               
               
                 73 
                 5 
                 SGCD 
                 NM_000337 
                 RS4705006 
                 155,692,041 
                 331 
                 906 
               
               
                 73 
                 5 
                 SGCD 
                 NM_000337 
                 RS7722282 
                 155,730,412 
                 332 
                 907 
               
               
                 73 
                 5 
                 SGCD 
                 NM_000337 
                 RS6556574 
                 155,747,541 
                 333 
                 908 
               
               
                 73 
                 5 
                 SGCD 
                 NM_000337 
                 RS4704798 
                 155,749,323 
                 334 
                 909 
               
               
                 73 
                 5 
                 SGCD 
                 NM_000337 
                 RS4705013 
                 155,765,029 
                 335 
                 910 
               
               
                 73 
                 5 
                 SGCD 
                 NM_000337 
                 RS11135202 
                 155,783,889 
                 336 
                 911 
               
               
                 73 
                 5 
                 SGCD 
                 NM_000337 
                 RS2055611 
                 155,796,281 
                 337 
                 912 
               
               
                 73 
                 5 
                 SGCD 
                 NM_000337 
                 RS4704804 
                 155,840,065 
                 338 
                 913 
               
               
                 73 
                 5 
                 SGCD 
                 NM_000337 
                 RS256825 
                 155,867,548 
                 339 
                 914 
               
               
                 73 
                 5 
                 SGCD 
                 NM_000337 
                 RS4705019 
                 155,886,086 
                 340 
                 915 
               
               
                 73 
                 5 
                 SGCD 
                 NM_000337 
                 RS6556750 
                 155,990,742 
                 341 
                 916 
               
               
                 73 
                 5 
                 SGCD 
                 NM_000337 
                 RS6871079 
                 155,994,305 
                 342 
                 917 
               
               
                 73 
                 5 
                 SGCD 
                 NM_000337 
                 RS32054 
                 156,008,460 
                 343 
                 918 
               
               
                 73 
                 5 
                 SGCD 
                 NM_000337 
                 RS6890150 
                 156,050,193 
                 344 
                 919 
               
               
                 73 
                 5 
                 SGCD 
                 NM_000337 
                 RS961272 
                 156,113,944 
                 345 
                 920 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS264869 
                 168,999,444 
                 346 
                 921 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS264834 
                 169,015,068 
                 347 
                 922 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS2244445 
                 169,034,177 
                 348 
                 923 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS2112703 
                 169,059,675 
                 349 
                 924 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS2279318 
                 169,063,452 
                 350 
                 925 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS10038749 
                 169,081,158 
                 351 
                 926 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS262865 
                 169,094,611 
                 352 
                 927 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS1680567 
                 169,145,733 
                 353 
                 928 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS688881 
                 169,186,359 
                 354 
                 929 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS261623 
                 169,200,362 
                 355 
                 930 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS2291229 
                 169,220,956 
                 356 
                 931 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS11740057 
                 169,237,503 
                 357 
                 932 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS155022 
                 169,273,854 
                 358 
                 933 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS259894 
                 169,291,461 
                 359 
                 934 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS1422694 
                 169,319,665 
                 360 
                 935 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS4867906 
                 169,338,200 
                 361 
                 936 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS3763048 
                 169,394,125 
                 362 
                 937 
               
               
                 57 
                 5 
                 DOCK2 
                 NM_004946 
                 RS6879798 
                 169,439,532 
                 363 
                 938 
               
               
                 28 
                 5 
                 LCP2 
                 NM_005565 
                 RS315717 
                 169,617,741 
                 364 
                 939 
               
               
                 28 
                 5 
                 LCP2 
                 NM_005565 
                 RS315745 
                 169,630,285 
                 365 
                 940 
               
               
                 28 
                 5 
                 LCP2 
                 NM_005565 
                 RS315721 
                 169,647,616 
                 366 
                 941 
               
               
                 28 
                 5 
                 LCP2 
                 NM_005565 
                 RS3761750 
                 169,657,817 
                 367 
                 942 
               
               
                 9 
                 6 
                 TDRD6 
                 NM_001010870 
                 RS12528857 
                 46,777,895 
                 368 
                 943 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS1051931 
                 46,780,902 
                 369 
                 944 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS2216465 
                 46,783,978 
                 370 
                 945 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS4498351 
                 46,784,742 
                 371 
                 946 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS1805018 
                 46,787,262 
                 372 
                 947 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS6899519 
                 46,789,859 
                 373 
                 948 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS1362931 
                 46,790,038 
                 374 
                 949 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS1805017 
                 46,792,181 
                 375 
                 950 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS6929105 
                 46,793,245 
                 376 
                 951 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS12195701 
                 46,795,378 
                 377 
                 952 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS3799863 
                 46,795,750 
                 378 
                 953 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS3799862 
                 46,795,890 
                 379 
                 954 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS3799861 
                 46,797,488 
                 380 
                 955 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS12528807 
                 46,804,466 
                 381 
                 956 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS9357514 
                 46,804,800 
                 382 
                 957 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS9381475 
                 46,807,251 
                 383 
                 958 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS1421378 
                 46,811,472 
                 384 
                 959 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS1421379 
                 46,813,953 
                 385 
                 960 
               
               
                 3 
                 6 
                 PLA2G7 
                 U24577 
                 RS1862008 
                 46,818,238 
                 386 
                 961 
               
               
                 37 
                 6 
                 AIM1 
                 AI800499 
                 RS1159148 
                 107,073,878 
                 387 
                 962 
               
               
                 14 
                 6 
                 C6ORF204 
                 NM_206921 
                 RS6929390 
                 118,969,838 
                 388 
                 963 
               
               
                 14 
                 6 
                 C6ORF204 
                 NM_206921 
                 RS9489433 
                 118,973,699 
                 389 
                 964 
               
               
                 5 
                 6 
                 PLN 
                 M63603 
                 RS9489434 
                 118,976,196 
                 390 
                 965 
               
               
                 5 
                 6 
                 PLN 
                 M63603 
                 RS3752581 
                 118,976,423 
                 391 
                 966 
               
               
                 5 
                 6 
                 PLN 
                 M63603 
                 RS9489437 
                 118,981,038 
                 392 
                 967 
               
               
                 5 
                 6 
                 PLN 
                 M63603 
                 RS9481825 
                 118,982,785 
                 393 
                 968 
               
               
                 5 
                 6 
                 PLN 
                 M63603 
                 RS503031 
                 118,983,503 
                 394 
                 969 
               
               
                 5 
                 6 
                 PLN 
                 M63603 
                 RS12198461 
                 118,987,333 
                 395 
                 970 
               
               
                 5 
                 6 
                 PLN 
                 M63603 
                 6P0326 
                 118,988,353 
                 396 
                 971 
               
               
                 5 
                 6 
                 PLN 
                 M63603 
                 RS1051429 
                 118,988,515 
                 397 
                 972 
               
               
                 14 
                 6 
                 C6ORF204 
                 NM_206921 
                 RS1998482 
                 118,992,805 
                 398 
                 973 
               
               
                 14 
                 6 
                 C6ORF204 
                 NM_206921 
                 RS763254 
                 118,993,308 
                 399 
                 974 
               
               
                 14 
                 6 
                 C6ORF204 
                 NM_206921 
                 RS3734382 
                 118,993,654 
                 400 
                 975 
               
               
                 14 
                 6 
                 C6ORF204 
                 NM_206921 
                 RS3734381 
                 118,993,996 
                 401 
                 976 
               
               
                 51 
                 6 
                 OPRM1 
                 L25119 
                 RS1799972 
                 154,452,810 
                 402 
                 977 
               
               
                 51 
                 6 
                 OPRM1 
                 L25119 
                 RS1799971 
                 154,452,911 
                 403 
                 978 
               
               
                 51 
                 6 
                 OPRM1 
                 L25119 
                 RS510769 
                 154,454,133 
                 404 
                 979 
               
               
                 51 
                 6 
                 OPRM1 
                 L25119 
                 RS524731 
                 154,467,206 
                 405 
                 980 
               
               
                 51 
                 6 
                 OPRM1 
                 L25119 
                 RS3823010 
                 154,471,266 
                 406 
                 981 
               
               
                 51 
                 6 
                 OPRM1 
                 L25119 
                 RS495491 
                 154,474,656 
                 407 
                 982 
               
               
                 51 
                 6 
                 OPRM1 
                 L25119 
                 RS2075572 
                 154,504,118 
                 408 
                 983 
               
               
                 51 
                 6 
                 OPRM1 
                 L25119 
                 RS609148 
                 154,523,128 
                 409 
                 984 
               
               
                 51 
                 6 
                 OPRM1 
                 L25119 
                 RS4870268 
                 154,564,440 
                 410 
                 985 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS16148 
                 24,095,578 
                 411 
                 986 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS16147 
                 24,096,650 
                 412 
                 987 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS16143 
                 24,097,828 
                 413 
                 988 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS16478 
                 24,097,848 
                 414 
                 989 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS16142 
                 24,097,910 
                 415 
                 990 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS16141 
                 24,097,999 
                 416 
                 991 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS16140 
                 24,098,048 
                 417 
                 992 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS16139 
                 24,098,119 
                 418 
                 993 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS5572 
                 24,098,183 
                 419 
                 994 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS9785023 
                 24,098,249 
                 420 
                 995 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS16138 
                 24,098,735 
                 421 
                 996 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS1468271 
                 24,100,221 
                 422 
                 997 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS5574 
                 24,102,373 
                 423 
                 998 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS16132 
                 24,102,760 
                 424 
                 999 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS16131 
                 24,103,077 
                 425 
                 1000 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS16475 
                 24,104,726 
                 426 
                 1001 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS16126 
                 24,104,757 
                 427 
                 1002 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS16474 
                 24,106,850 
                 428 
                 1003 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS16473 
                 24,106,891 
                 429 
                 1004 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS16120 
                 24,107,964 
                 430 
                 1005 
               
               
                 44 
                 7 
                 NPY 
                 NM_000905 
                 RS16119 
                 24,108,170 
                 431 
                 1006 
               
               
                 17 
                 7 
                 POR 
                 NM_000941 
                 RS3898649 
                 75,191,543 
                 432 
                 1007 
               
               
                 17 
                 7 
                 POR 
                 NM_000941 
                 RS1966363 
                 75,221,588 
                 433 
                 1008 
               
               
                 17 
                 7 
                 POR 
                 NM_000941 
                 RS2868178 
                 75,234,751 
                 434 
                 1009 
               
               
                 17 
                 7 
                 POR 
                 NM_000941 
                 RS7804806 
                 75,240,333 
                 435 
                 1010 
               
               
                 17 
                 7 
                 POR 
                 NM_000941 
                 RS4732513 
                 75,252,259 
                 436 
                 1011 
               
               
                 17 
                 7 
                 POR 
                 NM_000941 
                 RS10954732 
                 75,255,800 
                 437 
                 1012 
               
               
                 38 
                 7 
                 ABCB1 
                 M14758 
                 RS1045642 
                 86,783,296 
                 438 
                 1013 
               
               
                 38 
                 7 
                 ABCB1 
                 M14758 
                 RS1128503 
                 86,824,252 
                 439 
                 1014 
               
               
                 38 
                 7 
                 ABCB1 
                 M14758 
                 RS9282564 
                 86,874,091 
                 440 
                 1015 
               
               
                 38 
                 7 
                 ABCB1 
                 M14758 
                 RS2214102 
                 86,874,152 
                 441 
                 1016 
               
               
                 39 
                 9 
                 ROR2 
                 M97639 
                 RS1027268 
                 91,450,905 
                 442 
                 1017 
               
               
                 39 
                 9 
                 ROR2 
                 M97639 
                 RS10820899 
                 91,561,596 
                 443 
                 1018 
               
               
                 39 
                 9 
                 ROR2 
                 M97639 
                 RS2230578 
                 91,565,483 
                 444 
                 1019 
               
               
                 39 
                 9 
                 ROR2 
                 M97639 
                 RS4073735 
                 91,567,970 
                 445 
                 1020 
               
               
                 39 
                 9 
                 ROR2 
                 M97639 
                 RS9409456 
                 91,574,116 
                 446 
                 1021 
               
               
                 39 
                 9 
                 ROR2 
                 M97639 
                 RS16907720 
                 91,579,352 
                 447 
                 1022 
               
               
                 39 
                 9 
                 ROR2 
                 M97639 
                 RS3935601 
                 91,588,255 
                 448 
                 1023 
               
               
                 39 
                 9 
                 ROR2 
                 M97639 
                 RS9409461 
                 91,610,544 
                 449 
                 1024 
               
               
                 39 
                 9 
                 ROR2 
                 M97639 
                 RS7039620 
                 91,615,187 
                 450 
                 1025 
               
               
                 39 
                 9 
                 ROR2 
                 M97639 
                 RS4744098 
                 91,623,837 
                 451 
                 1026 
               
               
                 39 
                 9 
                 ROR2 
                 M97639 
                 RS4378021 
                 91,626,613 
                 452 
                 1027 
               
               
                 39 
                 9 
                 ROR2 
                 M97639 
                 RS2312732 
                 91,662,524 
                 453 
                 1028 
               
               
                 39 
                 9 
                 ROR2 
                 M97639 
                 RS1881385 
                 91,676,336 
                 454 
                 1029 
               
               
                 39 
                 9 
                 ROR2 
                 M97639 
                 RS10116351 
                 91,731,257 
                 455 
                 1030 
               
               
                 39 
                 9 
                 ROR2 
                 M97639 
                 RS10512219 
                 91,735,571 
                 456 
                 1031 
               
               
                 39 
                 9 
                 ROR2 
                 M97639 
                 RS1892263 
                 91,767,156 
                 457 
                 1032 
               
               
                 70 
                 11 
                 TCIRG1 
                 NM_006019 
                 RS906713 
                 67,570,506 
                 458 
                 1033 
               
               
                 70 
                 11 
                 TCIRG1 
                 NM_006019 
                 RS2075609 
                 67,573,512 
                 459 
                 1034 
               
               
                 70 
                 11 
                 TCIRG1 
                 NM_006019 
                 RS11228127 
                 67,574,452 
                 460 
                 1035 
               
               
                 70 
                 11 
                 TCIRG1 
                 NM_006019 
                 RS11481 
                 67,576,911 
                 461 
                 1036 
               
               
                 10 
                 12 
                 TNFRSF1A 
                 NM_001065 
                 RS4149578 
                 6,317,698 
                 462 
                 1037 
               
               
                 10 
                 12 
                 TNFRSF1A 
                 NM_001065 
                 RS4149577 
                 6,317,783 
                 463 
                 1038 
               
               
                 10 
                 12 
                 TNFRSF1A 
                 NM_001065 
                 RS4149576 
                 6,319,376 
                 464 
                 1039 
               
               
                 10 
                 12 
                 TNFRSF1A 
                 NM_001065 
                 RS4149573 
                 6,319,645 
                 465 
                 1040 
               
               
                 10 
                 12 
                 TNFRSF1A 
                 NM_001065 
                 RS4149570 
                 6,321,851 
                 466 
                 1041 
               
               
                 65 
                 12 
                 PLXNC1 
                 AF030339 
                 RS2230754 
                 93,045,974 
                 467 
                 1042 
               
               
                 65 
                 12 
                 PLXNC1 
                 AF030339 
                 RS7131826 
                 93,048,788 
                 468 
                 1043 
               
               
                 65 
                 12 
                 PLXNC1 
                 AF030339 
                 RS11107420 
                 93,057,281 
                 469 
                 1044 
               
               
                 65 
                 12 
                 PLXNC1 
                 AF030339 
                 RS3858609 
                 93,067,143 
                 470 
                 1045 
               
               
                 65 
                 12 
                 PLXNC1 
                 AF030339 
                 RS6538486 
                 93,078,458 
                 471 
                 1046 
               
               
                 65 
                 12 
                 PLXNC1 
                 AF030339 
                 RS10859685 
                 93,097,105 
                 472 
                 1047 
               
               
                 65 
                 12 
                 PLXNC1 
                 AF030339 
                 RS7296806 
                 93,099,026 
                 473 
                 1048 
               
               
                 65 
                 12 
                 PLXNC1 
                 AF030339 
                 RS3847813 
                 93,101,925 
                 474 
                 1049 
               
               
                 65 
                 12 
                 PLXNC1 
                 AF030339 
                 RS2305971 
                 93,105,768 
                 475 
                 1050 
               
               
                 65 
                 12 
                 PLXNC1 
                 AF030339 
                 RS2361355 
                 93,132,497 
                 476 
                 1051 
               
               
                 65 
                 12 
                 PLXNC1 
                 AF030339 
                 RS2291326 
                 93,151,413 
                 477 
                 1052 
               
               
                 65 
                 12 
                 PLXNC1 
                 AF030339 
                 RS2242498 
                 93,152,063 
                 478 
                 1053 
               
               
                 65 
                 12 
                 PLXNC1 
                 AF030339 
                 RS17022311 
                 93,155,862 
                 479 
                 1054 
               
               
                 65 
                 12 
                 PLXNC1 
                 AF030339 
                 RS832506 
                 93,174,211 
                 480 
                 1055 
               
               
                 65 
                 12 
                 PLXNC1 
                 AF030339 
                 RS1681866 
                 93,178,913 
                 481 
                 1056 
               
               
                 65 
                 12 
                 PLXNC1 
                 AF030339 
                 RS3803069 
                 93,186,271 
                 482 
                 1057 
               
               
                 48 
                 13 
                 PCCA 
                 X14608 
                 RS7325252 
                 99,547,355 
                 483 
                 1058 
               
               
                 48 
                 13 
                 PCCA 
                 X14608 
                 RS7993067 
                 99,566,316 
                 484 
                 1059 
               
               
                 48 
                 13 
                 PCCA 
                 X14608 
                 RS1890139 
                 99,580,093 
                 485 
                 1060 
               
               
                 48 
                 13 
                 PCCA 
                 X14608 
                 RS2152881 
                 99,615,996 
                 486 
                 1061 
               
               
                 48 
                 13 
                 PCCA 
                 X14608 
                 RS9518016 
                 99,626,614 
                 487 
                 1062 
               
               
                 48 
                 13 
                 PCCA 
                 X14608 
                 RS9743146 
                 99,667,871 
                 488 
                 1063 
               
               
                 48 
                 13 
                 PCCA 
                 X14608 
                 RS1112044 
                 99,682,492 
                 489 
                 1064 
               
               
                 48 
                 13 
                 PCCA 
                 X14608 
                 RS538229 
                 99,686,123 
                 490 
                 1065 
               
               
                 48 
                 13 
                 PCCA 
                 X14608 
                 RS7991183 
                 99,711,884 
                 491 
                 1066 
               
               
                 48 
                 13 
                 PCCA 
                 X14608 
                 RS9518035 
                 99,716,632 
                 492 
                 1067 
               
               
                 48 
                 13 
                 PCCA 
                 X14608 
                 RS9557413 
                 99,760,924 
                 493 
                 1068 
               
               
                 48 
                 13 
                 PCCA 
                 X14608 
                 RS9554686 
                 99,870,943 
                 494 
                 1069 
               
               
                 48 
                 13 
                 PCCA 
                 X14608 
                 RS8001633 
                 99,904,079 
                 495 
                 1070 
               
               
                 48 
                 13 
                 PCCA 
                 X14608 
                 RS1296332 
                 99,911,747 
                 496 
                 1071 
               
               
                 48 
                 13 
                 PCCA 
                 X14608 
                 RS3783171 
                 99,922,321 
                 497 
                 1072 
               
               
                 26 
                 14 
                 ITPK1 
                 NM_014216 
                 RS875395 
                 92,471,846 
                 498 
                 1073 
               
               
                 26 
                 14 
                 ITPK1 
                 NM_014216 
                 RS1043542 
                 92,476,815 
                 499 
                 1074 
               
               
                 26 
                 14 
                 ITPK1 
                 NM_014216 
                 RS11446 
                 92,477,001 
                 500 
                 1075 
               
               
                 26 
                 14 
                 ITPK1 
                 NM_014216 
                 RS10873430 
                 92,478,831 
                 501 
                 1076 
               
               
                 26 
                 14 
                 ITPK1 
                 NM_014216 
                 RS2295394 
                 92,482,496 
                 502 
                 1077 
               
               
                 26 
                 14 
                 ITPK1 
                 NM_014216 
                 RS2402226 
                 92,489,288 
                 503 
                 1078 
               
               
                 26 
                 14 
                 ITPK1 
                 NM_014216 
                 RS3825683 
                 92,518,490 
                 504 
                 1079 
               
               
                 26 
                 14 
                 ITPK1 
                 NM_014216 
                 RS4905025 
                 92,536,179 
                 505 
                 1080 
               
               
                 26 
                 14 
                 ITPK1 
                 NM_014216 
                 RS1614269 
                 92,573,258 
                 506 
                 1081 
               
               
                 26 
                 14 
                 ITPK1 
                 NM_014216 
                 RS1740596 
                 92,576,559 
                 507 
                 1082 
               
               
                 26 
                 14 
                 ITPK1 
                 NM_014216 
                 RS1740595 
                 92,582,283 
                 508 
                 1083 
               
               
                 26 
                 14 
                 ITPK1 
                 NM_014216 
                 RS2749509 
                 92,597,867 
                 509 
                 1084 
               
               
                 26 
                 14 
                 ITPK1 
                 NM_014216 
                 RS882023 
                 92,601,767 
                 510 
                 1085 
               
               
                 26 
                 14 
                 ITPK1 
                 NM_014216 
                 RS4905043 
                 92,619,762 
                 511 
                 1086 
               
               
                 26 
                 14 
                 ITPK1 
                 NM_014216 
                 HCV1258994 
                 92,623,971 
                 512 
                 1087 
               
               
                 26 
                 14 
                 ITPK1 
                 NM_014216 
                 RS941540 
                 92,630,797 
                 513 
                 1088 
               
               
                 26 
                 14 
                 ITPK1 
                 NM_014216 
                 RS768356 
                 92,646,296 
                 514 
                 1089 
               
               
                 55 
                 14 
                 C14ORF132 
                 AA149431 
                 RS4340260 
                 95,617,294 
                 515 
                 1090 
               
               
                 55 
                 14 
                 C14ORF132 
                 AA149431 
                 RS10140364 
                 95,621,356 
                 516 
                 1091 
               
               
                 55 
                 14 
                 C14ORF132 
                 AA149431 
                 RS1058102 
                 95,627,988 
                 517 
                 1092 
               
               
                 55 
                 14 
                 C14ORF132 
                 AA149431 
                 RS1062710 
                 95,629,212 
                 518 
                 1093 
               
               
                 55 
                 14 
                 C14ORF132 
                 AA149431 
                 RS2104290 
                 95,638,734 
                 519 
                 1094 
               
               
                 18 
                 15 
                 ANPEP 
                 M22324 
                 RS967451 
                 88,129,048 
                 520 
                 1095 
               
               
                 18 
                 15 
                 ANPEP 
                 M22324 
                 RS10584 
                 88,129,555 
                 521 
                 1096 
               
               
                 18 
                 15 
                 ANPEP 
                 M22324 
                 RS1992250 
                 88,134,984 
                 522 
                 1097 
               
               
                 18 
                 15 
                 ANPEP 
                 M22324 
                 RS7168793 
                 88,135,244 
                 523 
                 1098 
               
               
                 18 
                 15 
                 ANPEP 
                 M22324 
                 RS1439120 
                 88,139,197 
                 524 
                 1099 
               
               
                 18 
                 15 
                 ANPEP 
                 M22324 
                 RS1439119 
                 88,139,250 
                 525 
                 1100 
               
               
                 18 
                 15 
                 ANPEP 
                 M22324 
                 RS1439118 
                 88,139,516 
                 526 
                 1101 
               
               
                 18 
                 15 
                 ANPEP 
                 M22324 
                 RS753362 
                 88,141,538 
                 527 
                 1102 
               
               
                 18 
                 15 
                 ANPEP 
                 M22324 
                 RS893615 
                 88,141,723 
                 528 
                 1103 
               
               
                 18 
                 15 
                 ANPEP 
                 M22324 
                 RS2007084 
                 88,146,339 
                 529 
                 1104 
               
               
                 18 
                 15 
                 ANPEP 
                 M22324 
                 RS2305443 
                 88,147,865 
                 530 
                 1105 
               
               
                 18 
                 15 
                 ANPEP 
                 M22324 
                 RS25653 
                 88,150,562 
                 531 
                 1106 
               
               
                 8 
                 16 
                 MYH11 
                 D10667 
                 RS1050163 
                 15,718,524 
                 532 
                 1107 
               
               
                 8 
                 16 
                 MYH11 
                 D10667 
                 RS1050162 
                 15,718,563 
                 533 
                 1108 
               
               
                 8 
                 16 
                 MYH11 
                 D10667 
                 RS2075511 
                 15,725,642 
                 534 
                 1109 
               
               
                 8 
                 16 
                 MYH11 
                 D10667 
                 RS1050113 
                 15,746,535 
                 535 
                 1110 
               
               
                 8 
                 16 
                 MYH11 
                 D10667 
                 RS2272554 
                 15,757,705 
                 536 
                 1111 
               
               
                 8 
                 16 
                 MYH11 
                 D10667 
                 RS4781689 
                 15,772,973 
                 537 
                 1112 
               
               
                 8 
                 16 
                 MYH11 
                 D10667 
                 RS6498574 
                 15,795,766 
                 538 
                 1113 
               
               
                 8 
                 16 
                 MYH11 
                 D10667 
                 RS8044595 
                 15,813,631 
                 539 
                 1114 
               
               
                 8 
                 16 
                 MYH11 
                 D10667 
                 RS216152 
                 15,823,321 
                 540 
                 1115 
               
               
                 8 
                 16 
                 MYH11 
                 D10667 
                 RS1050111 
                 15,824,698 
                 541 
                 1116 
               
               
                 8 
                 16 
                 MYH11 
                 D10667 
                 RS215581 
                 15,840,675 
                 542 
                 1117 
               
               
                 8 
                 16 
                 MYH11 
                 D10667 
                 RS215571 
                 15,851,834 
                 543 
                 1118 
               
               
                 62 
                 16 
                 ITGAX 
                 Y00093 
                 RS1106398 
                 31,277,953 
                 544 
                 1119 
               
               
                 62 
                 16 
                 ITGAX 
                 Y00093 
                 RS4264407 
                 31,278,694 
                 545 
                 1120 
               
               
                 62 
                 16 
                 ITGAX 
                 Y00093 
                 RS2070896 
                 31,292,055 
                 546 
                 1121 
               
               
                 62 
                 16 
                 ITGAX 
                 Y00093 
                 RS2929 
                 31,300,809 
                 547 
                 1122 
               
               
                 62 
                 16 
                 ITGAX 
                 Y00093 
                 RS1140195 
                 31,301,680 
                 548 
                 1123 
               
               
                 35 
                 17 
                 GRN 
                 NM_002087 
                 RS3859268 
                 39,778,789 
                 549 
                 1124 
               
               
                 35 
                 17 
                 GRN 
                 NM_002087 
                 RS2879096 
                 39,779,082 
                 550 
                 1125 
               
               
                 35 
                 17 
                 GRN 
                 NM_002087 
                 RS3785817 
                 39,779,191 
                 551 
                 1126 
               
               
                 35 
                 17 
                 GRN 
                 NM_002087 
                 RS4792938 
                 39,780,125 
                 552 
                 1127 
               
               
                 35 
                 17 
                 GRN 
                 NM_002087 
                 RS9897526 
                 39,782,466 
                 553 
                 1128 
               
               
                 35 
                 17 
                 GRN 
                 NM_002087 
                 RS25646 
                 39,783,156 
                 554 
                 1129 
               
               
                 35 
                 17 
                 GRN 
                 NM_002087 
                 RS25647 
                 39,785,365 
                 555 
                 1130 
               
               
                 35 
                 17 
                 GRN 
                 NM_002087 
                 RS5848 
                 39,785,770 
                 556 
                 1131 
               
               
                 27 
                 18 
                 FVT1 
                 X63657 
                 RS6810 
                 59,149,381 
                 557 
                 1132 
               
               
                 27 
                 18 
                 FVT1 
                 X63657 
                 RS2850767 
                 59,152,094 
                 558 
                 1133 
               
               
                 27 
                 18 
                 FVT1 
                 X63657 
                 RS2236719 
                 59,157,272 
                 559 
                 1134 
               
               
                 27 
                 18 
                 FVTI 
                 X63657 
                 RS2849372 
                 59,164,885 
                 560 
                 1135 
               
               
                 27 
                 18 
                 FVT1 
                 X63657 
                 RS2850756 
                 59,168,088 
                 561 
                 1136 
               
               
                 67 
                 19 
                 HNRPM 
                 NM_005968 
                 RS6603076 
                 8,413,177 
                 562 
                 1137 
               
               
                 67 
                 19 
                 HNRPM 
                 NM_005968 
                 RS6603078 
                 8,417,325 
                 563 
                 1138 
               
               
                 7 
                 19 
                 PLAUR 
                 X74039 
                 RS4760 
                 48,844,940 
                 564 
                 1139 
               
               
                 7 
                 19 
                 PLAUR 
                 X74039 
                 RS2283628 
                 48,854,901 
                 565 
                 1140 
               
               
                 7 
                 19 
                 PLAUR 
                 X74039 
                 RS399145 
                 48,861,362 
                 566 
                 1141 
               
               
                 7 
                 19 
                 PLAUR 
                 X74039 
                 RS2286960 
                 48,863,865 
                 567 
                 1142 
               
               
                 74 
                 19 
                 BAX 
                 NM_138763 
                 RS1009316 
                 54,150,382 
                 568 
                 1143 
               
               
                 74 
                 19 
                 BAX 
                 NM_138763 
                 RS1B05419 
                 54,150,916 
                 569 
                 1144 
               
               
                 74 
                 19 
                 BAX 
                 NM_138763 
                 RS4645887 
                 54,151,688 
                 570 
                 1145 
               
               
                 74 
                 19 
                 BAX 
                 NM_138763 
                 RS2387583 
                 54,153,117 
                 571 
                 1146 
               
               
                 74 
                 19 
                 BAX 
                 NM_138763 
                 RS905238 
                 54,157,196 
                 572 
                 1147 
               
               
                 69 
                 22 
                 GTSE1 
                 NM_016426 
                 RS6008729 
                 45,047,947 
                 573 
                 1148 
               
               
                 64 
                 22 
                 TRMU 
                 NM_018006 
                 RS6007886 
                 45,058,315 
                 574 
                 1149 
               
               
                 64 
                 22 
                 TRMU 
                 NM_018006 
                 RS13585 
                 45,073,698 
                 575 
                 1150 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 4 
               
               
                   
               
               
                 (SEQ ID 
                 SNP Sequence 
                   
               
               
                 NO:) 
                 (polymorphism location is indicated in brackets) 
               
               
                   
               
             
            
               
                   1 
                 5′- GGACACAACAGGACCCACTG[G]GGAAAACAATGATGACTTGG -3′ 
                   
               
               
                   
               
               
                   2 
                 5′- CCCCTCCACTTTGCTCACCC[A]TCTTCCGGGCCCTGAACCCA -3′ 
               
               
                   
               
               
                   3 
                 5′- TCCTGTGCCGGCTGCAGGTA[T]GGAACAAGTAGGCTAGTGTC -3′ 
               
               
                   
               
               
                   4 
                 5′- AGGAAAGACTGTTGGGCCTC[G]GAAAACATCCCACGTGCTAG -3′ 
               
               
                   
               
               
                   5 
                 5′- GGGACTTGGTTTCATGTCTC[T]ATCTCTCAGTTCTGTTTCCC -3′ 
               
               
                   
               
               
                   6 
                 5′- ATAGAGAGGGTCTGTTAGGT[T]CTTGGGATCTTGTTCTTCAA -3′ 
               
               
                   
               
               
                   7 
                 5′- ATTCCAATTGAAGATTGAAA[G]TGGCCTGTTTGGTAAACTGG -3′ 
               
               
                   
               
               
                   8 
                 5′- TAACTCAAAGCACAAAGTTT[T]GAATTCCTACATTCTAAAGA -3′ 
               
               
                   
               
               
                   9 
                 5′- GTCACCTGCCTCGGAGCCAG[T]TAGGCTGTTTAACAGTGCAG -3′ 
               
               
                   
               
               
                  10 
                 5′- GGAGCTTTGGCATCGCAGAG[A]CTTGAGCTGAGTCTGGCTCT -3′ 
               
               
                   
               
               
                  11 
                 5′- CAGAGCCCCTCCCTCTAAAC[A]CAGTCTTTCAAAGGGATTGT -3′ 
               
               
                   
               
               
                  12 
                 5′- CAATTTCTTGCTGAAAGCCC[T]GAGTTATGCCAGACACTGTG -3′ 
               
               
                   
               
               
                  13 
                 5′- ACCTTTGCCCAGATCCAAAT[G]TTTTTTCTTCATTCGAAGCT -3′ 
               
               
                   
               
               
                  14 
                 5′- ACGGATCTCTTACCATTAAA[T]TCAGGTGGAGAGGGAGTGCC -3′ 
               
               
                   
               
               
                  15 
                 5′- TTTCACAGATGAGGAGGCTG[T]CCTCAGGAAATGTGACTCAG -3′ 
               
               
                   
               
               
                  16 
                 5′- CCAACACCACCCCTTGCCCA[G]CCAATGCACACAGTAGGGCT -3′ 
               
               
                   
               
               
                  17 
                 5′- CCCATATCATGCAGAGGATC[T]GGGATTTCAATCCAGGTCTA -3′ 
               
               
                   
               
               
                  18 
                 5′- TGACGTGTGCAGAGAGACAT[C]TCAGCCTGCCCTGCACTTGT -3′ 
               
               
                   
               
               
                  19 
                 5′- GGCAGCATATTAGAAAATAG[C]TTATGTTACAACAAAAACCC -3′ 
               
               
                   
               
               
                  20 
                 5′- TGCCCCTTCTCACTGGTCTG[C]GGCTGGCAGGGCCATCTTTC -3′ 
               
               
                   
               
               
                  21 
                 5′- GAATCCATCCCAAGGACACC[C]TTTGAAAACATGAAATAACA -3′ 
               
               
                   
               
               
                  22 
                 5′- CAGCGGGGAGGGGAAAGGTC[T]GAAATGAGGGGAGAGACGTG -3′ 
               
               
                   
               
               
                  23 
                 5′- GCTGGGCAGAGCCATTCCTG[A]GCTGGCTGGGTGTGTTTGGG -3′ 
               
               
                   
               
               
                  24 
                 5′- ACAGGCATCAGGGATACAGT[G]GTGAACAAGCATACACAATC -3′ 
               
               
                   
               
               
                  25 
                 5′- AGGTGAAGCTGAGGCCTGAG[C]CCAGAAGGAGAGAAAAGGAA -3′ 
               
               
                   
               
               
                  26 
                 5′- CACTCATTAATCCATTAAAC[C]ATTAATCTATTAATCCATGA -3′ 
               
               
                   
               
               
                  27 
                 5′- GTGTATGCTGTGAAGAAGGC[A]ACCCCCCTTCCTGCCCATCC -3′ 
               
               
                   
               
               
                  28 
                 5′- CTGTCACTATGCCCCTGCCT[T]TCTCAGTGTCTATCTCTGTT -3′ 
               
               
                   
               
               
                  29 
                 5′- GGGATGACAGTGAGAGGAGG[C]CAACAGTAAAAGGAGTCATA -3′ 
               
               
                   
               
               
                  30 
                 5′- GTGTGTCTGTCAGGGAATGT[G]TCCCTCTTCCATTCTCTGTG -3′ 
               
               
                   
               
               
                  31 
                 5′- CCATTCTTGGTGGTGAGCCT[G]GACTCTGAGCCTGGGATGTG -3′ 
               
               
                   
               
               
                  32 
                 5′- GTCTGGCTGCCCCTTGGCCT[C]CACYACAGTCAGGTCCAGCC -3′ 
               
               
                   
               
               
                  33 
                 5′- TTGAGGATTAAAGAGCAGAR[G]TCATGTAGCATCTGGCACAT -3′ 
               
               
                   
               
               
                  34 
                 5′- CGTCATGTAGCATCTGGCAC[G]TGGGGGAACGCAATGGAAGT -3′ 
               
               
                   
               
               
                  35 
                 5′- CAGAGAATATTTCACATGCA[T]GTAGCAAAAACACCAGGGGT -3′ 
               
               
                   
               
               
                  36 
                 5′- AACATGGATTAATGTGGGAA[C]TTGGCTTCAAGAACACAACC -3′ 
               
               
                   
               
               
                  37 
                 5′- ATTATTTCATTTTAAAACCA[T]AGAATAAAAATGACACCTGA -3′ 
               
               
                   
               
               
                  38 
                 5′- AAGCAGATTATGAGGCAGGT[C]CACCCCTCCCAGCACTGGGG -3′ 
               
               
                   
               
               
                  39 
                 5′- CCAGCCCTGTAGTGGACATA[T]TTGCCTTTGCCTATTCAGCA -3′ 
               
               
                   
               
               
                  40 
                 5′- GAACTCGGTGGAGGAGAAGA[G]AAACTCCAAGATGCTCCAGA -3′ 
               
               
                   
               
               
                  41 
                 5′- TGTGGGCTGGACTTAGCAAC[G]CACTTCTAACTAACAGAATG -3′ 
               
               
                   
               
               
                  42 
                 5′- GGTGTCAATTCACTCCCAGC[G]GCACTGACTGAGTGCTGACC -3′ 
               
               
                   
               
               
                  43 
                 5′- ATGTTAGGCGGTCCCACCTG[C]GTTCTGGAGATCTTCACACA -3′ 
               
               
                   
               
               
                  44 
                 5′- GGTGGGCAGAGGCTGGATCC[T]ATGGTGAGGAGTTTCCATTT -3′ 
               
               
                   
               
               
                  45 
                 5′- TTGCCATGGGCCACCTCTAC[C]GAGTGCTCGATGAACAACAA -3′ 
               
               
                   
               
               
                  46 
                 5′- TTTGGCTGGGGCAAGCTTAC[G]TGGTTCGGCAGTAGTACCAG -3′ 
               
               
                   
               
               
                  47 
                 5′- GTGGCCCCAGGAATGCGGGC[G]TCTGGTGGTATCTGGGCTGG -3′ 
               
               
                   
               
               
                  48 
                 5′- ATGCATTGTGGTAGATTCAT[A]CAATGGAGTATACACAGCAA -3′ 
               
               
                   
               
               
                  49 
                 5′- GTGGCAGCTGCCATTTTTCC[G]GTGCCACAAATGGTAGTTAC -3′ 
               
               
                   
               
               
                  50 
                 5′- TTGGGAGGAAGACCACAGAG[G]TGATGTGCCAGTCTCAGAAC -3′ 
               
               
                   
               
               
                  51 
                 5′- AAAATACAGGGTACAGGGAC[A]CTCAAAGAGTGATTTGCTTC -3′ 
               
               
                   
               
               
                  52 
                 5′- GTGAGATGGGGCACAGCAGC[G]GCCGGAAGGTTATTTGTGTG -3′ 
               
               
                   
               
               
                  53 
                 5′- GCAGGGCAGAGAAGGGGAAG[C]TGCTGGCTGCCCTCCTCACT -3′ 
               
               
                   
               
               
                  54 
                 5′- GCTCCTGGATTCACTCCTTT[C]ATCCTCACCTCAATCCTTTG -3′ 
               
               
                   
               
               
                  55 
                 5′- AGTTGGCTTGTATGGACCCC[G]CCGATGACGGACAGTTCCAA -3′ 
               
               
                   
               
               
                  56 
                 5′- AGTGGATTGAGGATGGACAT[G]TGTATCTGGAAGCACCAAAA -3′ 
               
               
                   
               
               
                  57 
                 5′- CTGGGTTCACTGGAAATCAG[T]ATTAAGAATGTACAAGGGAA -3′ 
               
               
                   
               
               
                  58 
                 5′- ATGTAAACTGCCTTTGAAAG[C]CTATAACACAGTTCAGTTGG -3′ 
               
               
                   
               
               
                  59 
                 5′- ACTTAATCTTGCTCAGTTCC[T]CAGTTTACACTTTTGAATGG -3′ 
               
               
                   
               
               
                  60 
                 5′- GCAGCATAGATGAATGTAAT[A]TTGAAACAGGAAGATGTGTT -3′ 
               
               
                   
               
               
                  61 
                 5′- CTTAGCCTGCAATTGCAATC[C]GTATGGGACCATGAAGCAGC -3′ 
               
               
                   
               
               
                  62 
                 5′- TAGCCGTTTACAGAATATCC[G]GAATACCATTGAAGAGACTG -3′ 
               
               
                   
               
               
                  63 
                 5′- GTTTCAGATTTTGATAGGCG[C]GTGAACGATAACAAGACGGC -3′ 
               
               
                   
               
               
                  64 
                 5′- ATGAGGGAGAAATGCCCTTT[T]TGGCAATTGTTGGAGCTGGA -3′ 
               
               
                   
               
               
                  65 
                 5′- AGGAACAGTGCTACTTACTG[G]TGGGTAGACTGGGAGAGGTG -3′ 
               
               
                   
               
               
                  66 
                 5′- TTGGCAATGGGTAAGTCTAT[C]GTACTGTGTAAACTTGGACT -3′ 
               
               
                   
               
               
                  67 
                 5′- GATATAGATCTCTTGGAAAT[G]TAATAATGGTATGCAGGAAG -3′ 
               
               
                   
               
               
                  68 
                 5′- GCAACCCGGGGAAATACAGC[C]AAATGCACAAGTACTGGCTG -3′ 
               
               
                   
               
               
                  69 
                 5′- CTGTACAAACTTTCTTCCAT[A]ATTTTGATTATATCCATTTT -3′ 
               
               
                   
               
               
                  70 
                 5′- CCCTCATTATCTGCCTAAAC[G]ATTTTTTCTCAACTCCTATA -3′ 
               
               
                   
               
               
                  71 
                 5′- CTAGCACTGTACACACCCCA[C]ACTGTGTATGCTATTTGTTG -3′ 
               
               
                   
               
               
                  72 
                 5′- CAAAAGTTATCTCTAACCAA[T]GTACTCAAACAGAGTCTTTA -3′ 
               
               
                   
               
               
                  73 
                 5′- CCTTGTAAATCTCCACCTGA[G]ATTTCTCATGGTGTTGTAGC -3′ 
               
               
                   
               
               
                  74 
                 5′- TCCCATAGGAATTATAAAAT[G]GAAAAGTATGACAAAAATTT -3′ 
               
               
                   
               
               
                  75 
                 5′- AGGCCCTTCAGCTTCACCAC[C]TGCTTCTCTTTAAACAAGTC -3′ 
               
               
                   
               
               
                  76 
                 5′- GATAGAATTTGGCCCAGAGA[G]GTTAACTAATATATCCATGA -3′ 
               
               
                   
               
               
                  77 
                 5′- CTGTTTCTCCTTAAAATGGA[G]AAATGGCCTCTACAGAGTAG -3′ 
               
               
                   
               
               
                  78 
                 5′- GCTTGGTGGGGCCACTGGGC[G]TCTGTTTCTCGGGTGTTTTG -3′ 
               
               
                   
               
               
                  79 
                 5′- CCATTCCCTCGGCGAAGAGC[G]GAGGTTGAAGAAATGCTACT -3′ 
               
               
                   
               
               
                  80 
                 5′- GCAAGCGCCAGAGCCTCTGT[G]TGCTGCATTCGGCAACCACA -3′ 
               
               
                   
               
               
                  81 
                 5′- GGTTCCTGAAGGAGGAGTGG[A]AGTTTGGTAAATGGATGGAG -3′ 
               
               
                   
               
               
                  82 
                 5′- TTACCTGCTAAGGCCTGCAA[A]CTTGAGGATGTCCAGGGCTG -3′ 
               
               
                   
               
               
                  83 
                 5′- CCAGAAGGTTTCTTTGCTCC[C]CTTCCCTACAAAGACAGAGC -3′ 
               
               
                   
               
               
                  84 
                 5′- AATTCACTCCTTTAAAATAC[C]CAATGCAGTGTTTTTAGAAA -3′ 
               
               
                   
               
               
                  85 
                 5′- CCACTCCCTCTCCTGCTCTT[G]TGTGTGTGATCCAAAGGGAA -3′ 
               
               
                   
               
               
                  86 
                 5′- CAGGGACAGCTGAAGCCAAG[C]TCTCCCAAAGCAGCCTTGGC -3′ 
               
               
                   
               
               
                  87 
                 5′- GTCAGGAGCCTGGCCAGGCC[G]CACCCCTTGCTGTCTCAGCA -3′ 
               
               
                   
               
               
                  88 
                 5′- GGAGATTCTGCCTCAGGGCC[G]TGAGAGTCCCATCTTCAAGC -3′ 
               
               
                   
               
               
                  89 
                 5′- GCTCAGCTACCGTTGGTGGC[A]TTTATTAAACTGTGCACCCA -3′ 
               
               
                   
               
               
                  90 
                 5′- AAGGTGGCTGACTCCAGCCC[A]TTTGCCCTTGAACTGCTGAT -3′ 
               
               
                   
               
               
                  91 
                 5′- TGAAGACCTGAAAAGCAAAT[T]CCAGGCAGCCCCACTCCCTC -3′ 
               
               
                   
               
               
                  92 
                 5′- TTCTTTGTAATTTGGAATCC[A]CCTAATTTCCAAATGGGTTC -3′ 
               
               
                   
               
               
                  93 
                 5′- GGGACCTGGCCCTGGCCATC[C]GGGACAGTGAGCGACAGGGC -3′ 
               
               
                   
               
               
                  94 
                 5′- AGGTGGGGACCCGGCTCCAA[A]GGCACCCGGGTCTTCTGCAG -3′ 
               
               
                   
               
               
                  95 
                 5′- ACAGGCCGCTCTCCCAGCAG[C]GTGTTGAGGTGCACAGCCAG -3′ 
               
               
                   
               
               
                  96 
                 5′- TGGCGCAAGAGAACCAGGGC[G]TCTTCTTCTCGGGGGACTCC -3′ 
               
               
                   
               
               
                  97 
                 5′- TGCTGTGCCCACATCCCCTG[C]AACAGGCAGGCCAGCCTGTG -3′ 
               
               
                   
               
               
                  98 
                 5′- TGGTGAGTTATGGACCCYCC[T]ACCTCCACTACTACACTGTA -3′ 
               
               
                   
               
               
                  99 
                 5′- TCAGGGCCTGGGGCAGGCGC[G]GCACAGCCCCCACCGCTGCT -3′ 
               
               
                   
               
               
                 100 
                 5′- GCATGGCATGCGGAAGATGG[T]GAAGAATGTTTTATGGCCTC -3′ 
               
               
                   
               
               
                 101 
                 5′- TCTCAGTAGCTGAGACCTGA[G]AAATTTGGAGAATCACTTTG -3′ 
               
               
                   
               
               
                 102 
                 5′- ACATGAGGCCACTGAGGCAG[C]CCTCTTTCCTTCCCCTTCTC -3′ 
               
               
                   
               
               
                 103 
                 5′- CCTATTCTTAATCCTATTTT[G]CAAATGAAGTGACTTGCCCA -3′ 
               
               
                   
               
               
                 104 
                 5′- GGAATGGGTCAAGAATGTTC[G]TTCCCTTCTGAATGTCCCTG -3′ 
               
               
                   
               
               
                 105 
                 5′- AAGCGGGGAGGAGCTAAATA[C]TATTTTTCTCTCCTTGTTCA -3′ 
               
               
                   
               
               
                 106 
                 5′- AACTTGGAACATCTCCGCAA[C]AAGACAGAGGATCTGGAAGC -3′ 
               
               
                   
               
               
                 107 
                 5′- ACATCGCAGAAGGTGGCTCG[A]AAATTCTGGTGGAAGAACGT -3′ 
               
               
                   
               
               
                 108 
                 5′- TTCCCGAGGCCCTGCTGCCA[T]GTTGTATGCCCCAGAAGGTA -3′ 
               
               
                   
               
               
                 109 
                 5′- TGAGAGTCAGGGTTTGGGAC[C]AGATTGGCAAGTCAGGCTCT -3′ 
               
               
                   
               
               
                 110 
                 5′- TCTCCAGGACCTAGTATGGT[G]CCTGACCGTGGCACTCATAG -3′ 
               
               
                   
               
               
                 111 
                 5′- CTACCTCAGAGTATGTGCCC[A]TTGGATGGTGGCTGTTATTC -3′ 
               
               
                   
               
               
                 112 
                 5′- CTAGTCTCTGAGCTGAGTGC[C]GACTTAGGGAGGCAATGTTA -3′ 
               
               
                   
               
               
                 113 
                 5′- ACAGTGTGGCGTAAGGCAGT[G]TGGCCCTTGTCCTCTTGCTT -3′ 
               
               
                   
               
               
                 114 
                 5′- TTAGGGCAGCTGTGCATTGA[C]TGGGTAGACGCCATTCTGGA -3′ 
               
               
                   
               
               
                 115 
                 5′- TGAGGCCCCCACCTGGCCCT[T]ATCTGCCCCTGACATCTAGA -3′ 
               
               
                   
               
               
                 116 
                 5′- CGCATAATTTCCGTCACCTC[A]TTCGCCTGCTGGTGGCACCG -3′ 
               
               
                   
               
               
                 117 
                 5′- CCCCAACATGTGCACCCCTG[C]ATTTCCTGTCATGCCACAGA -3′ 
               
               
                   
               
               
                 118 
                 5′- CCAGATCTCCATCATTGGCG[T]TAGTCTCTGGTCACCTGACT -3′ 
               
               
                   
               
               
                 119 
                 5′- TTTGTTCTGACTTTACATCC[C]CTTCCCCAGGTCACTTTTCA -3′ 
               
               
                   
               
               
                 120 
                 5′- ATTCCTGTCCCTTGTGCCGC[T]ATGAGCTGCCCACTGATGAC -3′ 
               
               
                   
               
               
                 121 
                 5′- TTTGATACCAAGAACACATT[T]CTGCATGAATCCTCCAGCAA -3′ 
               
               
                   
               
               
                 122 
                 5′- TCTAAAATTAGGGGTTTGAT[T]TAGCTTATCTGGAAGGTGTT -3′ 
               
               
                   
               
               
                 123 
                 5′- GATGCGGTCTGGAAAGCACC[A]GGGTGGCCGTCGGCTGACGC -3′ 
               
               
                   
               
               
                 124 
                 5′- CTCCGTGGAACTTCTCCTGG[T]ACAAATTCTGTTCCTAGGGA -3′ 
               
               
                   
               
               
                 125 
                 5′- GAGGGGAGCCACAGGAATGG[C]CGTGGCCAGAAGCCCTTCTC -3′ 
               
               
                   
               
               
                 126 
                 5′- GGCACCTTTTCCCTGATAAG[A]CACAAATCATAACCAAACAA -3′ 
               
               
                   
               
               
                 127 
                 5′- TTGCACTCCAGTTTTTTTTT[C]TTTAAAAAAGCGGTTTCTAC -3′ 
               
               
                   
               
               
                 128 
                 5′- GAAAAGGCTGTCTGATTATC[G]TGTCATCCAAAAAAAACAGA -3′ 
               
               
                   
               
               
                 129 
                 5′- GAACTAAGAGGAATAAAGGT[A]TTGCTTTATACCTGTCCCTA -3′ 
               
               
                   
               
               
                 130 
                 5′- ACTAACATGTCCTGCCTATT[A]TCTGTCAGCTGCAAGGTACT -3′ 
               
               
                   
               
               
                 131 
                 5′- GCTGACCCAGGGTCCACATG[C]TCTTTTTCTAACTTGTTCAT -3′ 
               
               
                   
               
               
                 132 
                 5′- TGCTTCCCCATTTCTGTCCT[A]AAAGCCCTCTGGCAAGACTG -3′ 
               
               
                   
               
               
                 133 
                 5′- CAGTGATGAACTCCTGGGCT[T]AAGTGACCCACCCGCCTCTG -3′ 
               
               
                   
               
               
                 134 
                 5′- GCGACTTCGACTAAGCAACA[T]TGCATCTATTTTCATGCAAC -3′ 
               
               
                   
               
               
                 135 
                 5′- CCTCAAATGTTAGAGTCAGT[G]CACCAGCTCATAGTTTCCAT -3′ 
               
               
                   
               
               
                 136 
                 5′- CGTTTAATTCTTTCTCATCA[G]TTTCCTAGGGCATTTGCAAT -3′ 
               
               
                   
               
               
                 137 
                 5′- CATCAGAGTTTTATGATTAG[T]AGATATATCTTAACTGACAC -3′ 
               
               
                   
               
               
                 138 
                 5′- AGCAAAACCAAAGAAATCAGC[G]GAAGACCATAAAAACAGACG -3′ 
               
               
                   
               
               
                 139 
                 5′- CTATAAAATTAGTATGCTTA[A]AATTATTAAACATATACAGA -3′ 
               
               
                   
               
               
                 140 
                 5′- TAAACACTTTAATGCAGTGA[T]ACTCAGGTATAAAACTCAGA -3′ 
               
               
                   
               
               
                 141 
                 5′- ATAGAAGACAAAGTTTTCAT[C]CGTCTCATTCAAGTTCACTT -3′ 
               
               
                   
               
               
                 142 
                 5′- AGTGCAGGGCAGGACTGCTG[T]CTGACCCCGGGCCACCTGGA -3′ 
               
               
                   
               
               
                 143 
                 5′- AACCTCTTGGTACATGTTAG[G]GGAAATGAAGCTGGCAACAA -3′ 
               
               
                   
               
               
                 144 
                 5′- TCATCAGATCAAGGACATTA[T]GGAATTAAAGGGCTCTAAGA -3′ 
               
               
                   
               
               
                 145 
                 5′- CCACTGCTATTGGTTATTTA[T]CTAGCATCCATTTCCCTTTA -3′ 
               
               
                   
               
               
                 146 
                 5′- ATCTACCTCTCCTGCCTCAT[C]TATTATTACCCAGCCCCTTC -3′ 
               
               
                   
               
               
                 147 
                 5′- GTCAATTGCAAATGGAGGTG[G]GACCTGAGAAAACAAAGAAA -3′ 
               
               
                   
               
               
                 148 
                 5′- GAGTGTGTAACAACTCACCT[A]CCAAATCGACTAGCCCTTAG -3′ 
               
               
                   
               
               
                 149 
                 5′- CTTGTAAGCCATCTTAAGCC[A]TTATAGGCCTAAGATGTATA -3′ 
               
               
                   
               
               
                 150 
                 5′- CTTGAGACCTGTGTCTCCTC[G]TGTTCACACTGTTCCTGACT -3′ 
               
               
                   
               
               
                 151 
                 5′- GAGGCATGGGTTGAACTGCA[C]TCACATATGTACTTAAAAGA -3′ 
               
               
                   
               
               
                 152 
                 5′- TGTTTCTTGAAGTTTGACTA[T]TTAAAAACATAGGTGTAAAG -3′ 
               
               
                   
               
               
                 153 
                 5′- AGAGTCACGGCATGTGGGAA[G]GTTTCCATGGACACTGGATC -3′ 
               
               
                   
               
               
                 154 
                 5′- AATGAGATCTTATGTCAAGG[C]TTTAATCTTTGGTATTCCAA -3′ 
               
               
                   
               
               
                 155 
                 5′- TCTGGACCTCAGTTTCCTCA[G]TGAGCTGGTAAGAATGCACT -3′ 
               
               
                   
               
               
                 156 
                 5′- AGGTTGATAGCAATGTTTGG[A]AGATATGTCCTAGAAGTGTT -3′ 
               
               
                   
               
               
                 157 
                 5′- GCATGATAACCCTAGCCATC[G]CTAAATATTATAGCTTCCTT -3′ 
               
               
                   
               
               
                 158 
                 5′- CTCCAGTTTCTCCCTTTCTC[A]CCAACTAGGTCCATCCAAAC -3′ 
               
               
                   
               
               
                 159 
                 5′- AACTGTAAGGATCTCTTGCT[G]TATATACTATTGGGGGAACA -3′ 
               
               
                   
               
               
                 160 
                 5′- CCTTAGCTCTTCCTAAAACA[T]ACAATCATAAAGGAAACCGT -3′ 
               
               
                   
               
               
                 161 
                 5′- CTGACAGTAAAGGGAACTCA[T]TATGTCTGAGTCTTTGCTCA -3′ 
               
               
                   
               
               
                 162 
                 5′- AACATTTACAGAAGCGAGAA[T]AAGTTTTGTTTGCTTTTGTT -3′ 
               
               
                   
               
               
                 163 
                 5′- TAAGTTCAATAAATCCCAAA[T]TGCACACTCTGAATTAGGGG -3′ 
               
               
                   
               
               
                 164 
                 5′- AAGATAGCCATCTTTGGGCA[C]AGAGTCATGAAATGTACCCT -3′ 
               
               
                   
               
               
                 165 
                 5′- GCTGGGCCGACGGGGACGAG[G]CGGCGACTGGAGCAGCAGCG -3′ 
               
               
                   
               
               
                 166 
                 5′- CTCTGTCTTGGTCACTGTGC[A]AGGATTGAAGGGAACTATTG -3′ 
               
               
                   
               
               
                 167 
                 5′- ATCGTCTTTTACAATAAGAT[A]CATGCCCCTATGAGTATTTT -3′ 
               
               
                   
               
               
                 168 
                 5′- AAGGAGAAAAACAGTGAACC[G]TAGTTCTTACTGCTCACACT -3′ 
               
               
                   
               
               
                 169 
                 5′- GATTATTTGATTGCCATGAA[T]GAAGCTGAATTACATAATTC -3′ 
               
               
                   
               
               
                 170 
                 5′- AGGGACCTGTCTTCAGAATC[G]AAGAAGCATAATGTCCTTAA -3′ 
               
               
                   
               
               
                 171 
                 5′- TAGAGTCCCTACCATGCACC[G]TGGGCAAGAAGTCAGTTCTG -3′ 
               
               
                   
               
               
                 172 
                 5′- TCGGGTCTCTTACCATGCCC[A]CCCTCCCTTCCTCAGGGAAT -3′ 
               
               
                   
               
               
                 173 
                 5′- AGGACCTTCAGAGACCCCGC[A]TTCTCTGAAACCAGGATGGA -3′ 
               
               
                   
               
               
                 174 
                 5′- CAGGGGCTGCACTCACCATC[A]TCTGACACCTCCACTTCATC -3′ 
               
               
                   
               
               
                 175 
                 5′- GTACACAAGGGTAGGGCAGA[A]GATGGACAGCAGGGCAGAAT -3′ 
               
               
                   
               
               
                 176 
                 5′- AGTTTCTGCAGCACTTTATC[C]TTCCATCTGGCCATGAGGAA -3′ 
               
               
                   
               
               
                 177 
                 5′- CAGGCATTGAAGGTCAGCTT[C]TTCTCCTCCTGGGTGAGTTT -3′ 
               
               
                   
               
               
                 178 
                 5′- GGGCACGACCTACCATCCAC[A]GTGACTTGGCAGGAGCACTC -3′ 
               
               
                   
               
               
                 179 
                 5′- TTACTTCTATCCTTGCTTCT[C]GAACTGGTCATTCCCTGACT -3′ 
               
               
                   
               
               
                 180 
                 5′- AGAACAAGCTGTTAGCAGGA[T]GCCTCTGCTGCTGCGGGGCC -3′ 
               
               
                   
               
               
                 181 
                 5′- TCGGCTGGGATCTCCTTCAG[G]TCGTCTTCCGATAGGGTCTT -3′ 
               
               
                   
               
               
                 182 
                 5′- AGGCCTCAGGGACCCATAGC[G]GTCACTACCACCACCATCAG -3′ 
               
               
                   
               
               
                 183 
                 5′- TTGTCCAGAAATCACTGTGA[T]TGGATACACAAATGCAGCAC -3′ 
               
               
                   
               
               
                 184 
                 5′- CTTGGCTGCTGAATGGTGAG[T]TCCCCCTGCCCCAGCTCTCT -3′ 
               
               
                   
               
               
                 185 
                 5′- GAAGTCTTCTGAAGGACCGG[A]GTCTGCGGGGCCGTTCTGGG -3′ 
               
               
                   
               
               
                 186 
                 5′- TGGTGGCTTTTGTTTCTCTC[A]CAAATGACCTGTGTGGTGGT -3′ 
               
               
                   
               
               
                 187 
                 5′- AGGACGGGTCTCCACTGCTG[A]AGCTGAAAATCTATCCCTGT -3′ 
               
               
                   
               
               
                 188 
                 5′- TTTGTGACCTTGTATGGATG[-]ACTTCTCTGAATCTTATTTC -3′ 
               
               
                   
               
               
                 189 
                 5′- AAAACTCAATAAGATGCCTA[C]ATTTTATGCATCTCCATTAA -3′ 
               
               
                   
               
               
                 190 
                 5′- TTCACCATCCCTCTACTTTC[A]GCTTGCCAAAACTTACAGGA -3′ 
               
               
                   
               
               
                 191 
                 5′- TGGCCAGTGCTCAGCAGATG[C]AAGTTCCAAATCGAGTCACT -3′ 
               
               
                   
               
               
                 192 
                 5′- GCATGGAGTCAACTCTTGAG[G]GATCCACACTGAGGGAGGTT -3′ 
               
               
                   
               
               
                 193 
                 5′- TGAGTCCTGGTCCAGGGCCT[G]CTGGGGACTAGATAAGATGT -3′ 
               
               
                   
               
               
                 194 
                 5′- CAAGCTAGAGACTTGGTATA[T]AGCAGCAGTTACATGAGTGG -3′ 
               
               
                   
               
               
                 195 
                 5′- CAGACTGTGGACATCCGAAT[C]GGCAATGACATGAATTTAAG -3′ 
               
               
                   
               
               
                 196 
                 5′- AGGCACCAGGTCCCATGGCC[T]GTTTCCCCTGAGAAAACATT -3′ 
               
               
                   
               
               
                 197 
                 5′- ATGGAGAGCTGCCAAGCCAA[A]CCTGCCAGGGTCATCAGCTC -3′ 
               
               
                   
               
               
                 198 
                 5′- ATAGCTGTCCTTACTCCTTT[G]CTAGACAGACAGTGTCTTGG -3′ 
               
               
                   
               
               
                 199 
                 5′- GCTTTTTATACCGCTTAACG[T]AAATAATTTAAAAGGCTGTC -3′ 
               
               
                   
               
               
                 200 
                 5′- AGCTGCAATGCCTATGAGCA[A]GACCTGGGTTTGTACATCTT -3′ 
               
               
                   
               
               
                 201 
                 5′- CTAGGATAGCAGAGATATTA[T]TTCAGGATCAGATCTTGACT -3′ 
               
               
                   
               
               
                 202 
                 5′- TCTGGGGAGTCTTTAGCCCC[T]AGCAGAGGCCATTTCTAGCA -3′ 
               
               
                   
               
               
                 203 
                 5′- GAATAAAACTTACGGAGAGC[T]TCTAACTTCATTCAATTTGT -3′ 
               
               
                   
               
               
                 204 
                 5′- ATAATATATTTTAAGCAGGG[C]AGGGTATCCCAAGATCTCAA -3′ 
               
               
                   
               
               
                 205 
                 5′- GTATGGTAAAGAATCCCAGT[G]CTGCATCAATCAGTGGGCAA -3′ 
               
               
                   
               
               
                 206 
                 5′- TTTTCCTTACACCAAGCTTA[T]GTGGGTGGCTGTAGCCACAA -3′ 
               
               
                   
               
               
                 207 
                 5′- GCACCATGGGGGAAATTATC[A]GTATTATTTTTTTGAAATCA -3′ 
               
               
                   
               
               
                 208 
                 5′- TATAGYCAAAGAGTTGTGCA[G]TGATCACCTCAATGAATTTA -3′ 
               
               
                   
               
               
                 209 
                 5′- GTTCTGGGCAACTGCTTTAG[C]CTGAATGCAAAAAACTGGAA -3′ 
               
               
                   
               
               
                 210 
                 5′- AAACAAAAGCCCCACAGCAA[G]AAACAGGAAGGAAGGGGAAC -3′ 
               
               
                   
               
               
                 211 
                 5′- ATAGTGAGGGATGACTGTAT[T]TTCCACTTAAAAATCCCAAG -3′ 
               
               
                   
               
               
                 212 
                 5′- GGAAAATAAAACTGTACCTC[A]TCTCCAGTCTCCCCATATTT -3′ 
               
               
                   
               
               
                 213 
                 5′- TAATGGCTTTCAAAGTGCCT[A]AATTCCATTCTACACTAAAA -3′ 
               
               
                   
               
               
                 214 
                 5′- ACCTCAAAAGAAAAAATAAC[G]TAAACAATATTCAACTCAAG -3′ 
               
               
                   
               
               
                 215 
                 5′- GCTTGGTTCAGGCCCTGGTT[G]CATACCTGGATTTCAAATCT -3′ 
               
               
                   
               
               
                 216 
                 5′- ACCCACAGCTTTCAGCAGTG[C]AGAATATGAATGGAAACTGG -3′ 
               
               
                   
               
               
                 217 
                 5′- GAGTGAGGTAGAGAACAGGT[G]TAATTCACCATAAGTCCTGA -3′ 
               
               
                   
               
               
                 218 
                 5′- ACCTGGTTCTTTGAAAGAAC[C]AATAAAATTCACAAACTGCT -3′ 
               
               
                   
               
               
                 219 
                 5′- TTTTTCTCTTCAGCTGGCCC[A]AATTGGTTTCTGTTAATTTT -3′ 
               
               
                   
               
               
                 220 
                 5′- GAAGAGACTAAGAGAATCAC[A]GAAGAGAGAAGGAGGTCAAG -3′ 
               
               
                   
               
               
                 221 
                 5′- TCTTGAAGGGTTTTAGTTCC[A]TAAGTTCCAGGGAGGGGTCT -3′ 
               
               
                   
               
               
                 222 
                 5′- AAACGTTTAATTCTTCTGTG[G]GTTCTGTTCTAATTTCTGAG -3′ 
               
               
                   
               
               
                 223 
                 5′- AGGCCTAGAATTCTCTGAAA[T]GTCATTTTTCAGTTTCTACA -3′ 
               
               
                   
               
               
                 224 
                 5′- GTAGCCTTGCGCCTCACTCT[T]GTGATGGAGCCGCCTGCTAC -3′ 
               
               
                   
               
               
                 225 
                 5′- ATTGTCATTTTCCTTGTGTT[A]TATTGGTTCAGGCTATCCAA -3′ 
               
               
                   
               
               
                 226 
                 5′- CAAGGCATCTTGGCTCCTAC[G]TAGGGCCTTTTGGCTCCTCT -3′ 
               
               
                   
               
               
                 227 
                 5′- AGATCTCCAAGGTTTTCACC[G]AGAAACACTTGACCCGACTT -3′ 
               
               
                   
               
               
                 228 
                 5′- CCTCAATGCAGAGGGGTCAT[G]AGAGCAGGCTGGGAGCCAGA -3′ 
               
               
                   
               
               
                 229 
                 5′- GTTCCTCCTCAGAAACTGCC[T]TGTATGAGTTTGTATCCTTA -3′ 
               
               
                   
               
               
                 230 
                 5′- CATAGGCGAGGCCCAGCCCA[C]GTGTCCAGAGACATCTGTGA -3′ 
               
               
                   
               
               
                 231 
                 5′- GCTCTTCAAGGTCTGGTGCT[T]TCTTCCACAGTACTGTAGCC -3′ 
               
               
                   
               
               
                 232 
                 5′- AAATGGGTGCTCAGACCCCT[A]TCCTACTTACCTCAAAAGGT -3′ 
               
               
                   
               
               
                 233 
                 5′- TGTCAGCAGCCTGGTATTGG[G]AAGAGTTAAAGGAAAATCTC -3′ 
               
               
                   
               
               
                 234 
                 5′- CAGTTCAGGGGAGGAGCCTC[A]GGACGTCAGTGGCAAAATCA -3′ 
               
               
                   
               
               
                 235 
                 5′- GCATAGGCTTAACTCGCTGA[T]GAGTTAATTGTTTTATTTTT -3′ 
               
               
                   
               
               
                 236 
                 5′- AGGGGAAACGTCTCCCAGAT[C]GCTCCCTTGGCTTTGAGGCC -3′ 
               
               
                   
               
               
                 237 
                 5′- AGCCAAAGCCAGAGTGGCCA[C]GGCCCAGGGAGGGTGAGCTG -3′ 
               
               
                   
               
               
                 238 
                 5′- TTTCAGAGAGGGAAGCCAGA[G]GAGAAGAGGGTGCAGGCTGA -3′ 
               
               
                   
               
               
                 239 
                 5′- CAAGTCCTCCGGTTCTTCCT[C]GGGATTGGCGGGTCCACTTG -3′ 
               
               
                   
               
               
                 240 
                 5′- AGGCTGCCTCCGCACCTGAC[C]GCTGCCCAGGTGGGGTTTCC -3′ 
               
               
                   
               
               
                 241 
                 5′- TGGCTAGGACAGGGTCTCGG[G]CTAGGGAAGTGGTTTCTCTG -3′ 
               
               
                   
               
               
                 242 
                 5′- TTACGGGAAGCCCTTCTGGC[G]CTCACTCAGGGCAGCAGCTT -3′ 
               
               
                   
               
               
                 243 
                 5′- GCCTGGGCAGGAAGAGGGAC[T]AGAGGGTCTCCCACATGGGA -3′ 
               
               
                   
               
               
                 244 
                 5′- ATCGTGTTCCCCAGGAAGTT[G]TTCTTGATTTAGTTTAAACT -3′ 
               
               
                   
               
               
                 245 
                 5′- GAACCACCTTCTGTTGCCAG[T]CTGTACTCCTCATTTAGTTT -3′ 
               
               
                   
               
               
                 246 
                 5′- AAGGTGGGAGCCAGAGTGGG[C]TGCTGTAGGGGTGAGGGAGG -3′ 
               
               
                   
               
               
                 247 
                 5′- GCCATCCAGCGCGGCTGCTC[C]GGCGCCACCTCCATGGCCGG -3′ 
               
               
                   
               
               
                 248 
                 5′- TCCCTGGGCCCGTCGCCCTC[G]GGGCTCCCGCCGGAACTCCT -3′ 
               
               
                   
               
               
                 249 
                 5′- ACACAGACATTGTCGAGGGC[G]GGTCCCTCTTTATTGGCCAG -3′ 
               
               
                   
               
               
                 250 
                 5′- GCCTGGTGAGAGCAGATTTA[C]TCCAATTTATGGGCTGGAAC -3′ 
               
               
                   
               
               
                 251 
                 5′- CACACCGACACACATGGCCA[C]ACAATCAGATGCAACTCGGC -3′ 
               
               
                   
               
               
                 252 
                 5′- CTTGTTCACAGAAGTGGGAG[G]CAGGAGGGGGGGAGAAAGTG -3′ 
               
               
                   
               
               
                 253 
                 5′- AGGACCAGGCGGCTAAGCAG[G]GAGAAGAGCCAGAGGGGCGT -3′ 
               
               
                   
               
               
                 254 
                 5′- CGGGCCATGGACACCGACAC[G]CTGACACAGGTCAAGGAGAA -3′ 
               
               
                   
               
               
                 255 
                 5′- CTGCGGTTCAGCTCCTTGGT[G]AGATCTGTCATGTCTGTCTG -3′ 
               
               
                   
               
               
                 256 
                 5′- GCACGTCGGCTCTTGGTACA[G]AAGACGAACAGGGCTGCGGG -3′ 
               
               
                   
               
               
                 257 
                 5′- TCCCCCGGGGCCCTGAGCAA[C]GCATCAGCGCCAGTGGACTT -3′ 
               
               
                   
               
               
                 258 
                 5′- TTCACCAGGACCTGGAGCTC[G]GAGCCTACATGGAGGTCATT -3′ 
               
               
                   
               
               
                 259 
                 5′- ACGGTCACCACACCTGAGAG[T]GGTCCTGGGGCTGGCCCTGT -3′ 
               
               
                   
               
               
                 260 
                 5′- GCGGCAGCCATCACTCCACA[T]GCACAGGTGACCCAGGTCTT -3′ 
               
               
                   
               
               
                 261 
                 5′- AGGATGTTCTGGGAGCCACC[C]GTAGGCACGGGTGCCAGGGG -3′ 
               
               
                   
               
               
                 262 
                 5′- TGGAATGAGCAACACAGGAA[T]GCTCCAGTTGTCCAGACCAT -3′ 
               
               
                   
               
               
                 263 
                 5′- CGAGACTGGTTGGAAACACA[G]GAGTGCTGCTGGCTGCACCA -3′ 
               
               
                   
               
               
                 264 
                 5′- CCCCCATCCATTCCAGACCA[C]GTGACTGTTGAGATGTCTGT -3′ 
               
               
                   
               
               
                 265 
                 5′- TCGATGTGCGCCAGGAGTAC[C]CAGTGAGTCCTGGGGGAGGC -3′ 
               
               
                   
               
               
                 266 
                 5′- AGTTTGACCCAGCAGACTCC[G]GTTACCTTTACCTGATGACG -3′ 
               
               
                   
               
               
                 267 
                 5′- CCTACCTTGAGAAGCCTCCC[G]TTGACCGTGCCCAGGAAGAC -3′ 
               
               
                   
               
               
                 268 
                 5′- AGGCCTCCAGGAAGTGACCC[C]GAGACAATAACTGTGCAACT -3′ 
               
               
                   
               
               
                 269 
                 5′- GTAACTAAGCACACCCCTTA[C]AGAATTTTGGGAAGTCGCCC -3′ 
               
               
                   
               
               
                 270 
                 5′- TAAGCCAGAGGATGCTGTAG[A]GAGTACTTGTATGCAATAAC -3′ 
               
               
                   
               
               
                 271 
                 5′- CTTGTTGTCATGGTGCGTTG[G]AAGAGTAGCCAGTTGTCTTT -3′ 
               
               
                   
               
               
                 272 
                 5′- ATTAGTATGCAGGTCTTATC[T]ACCATTGGAATTAAGCTGTT -3′ 
               
               
                   
               
               
                 273 
                 5′- ACGTTTTTATCACACATTAA[G]CACTTGCATTAATTTTGGAG -3′ 
               
               
                   
               
               
                 274 
                 5′- GATGAGTTAAATGGGCTAGT[G]TCTAAATTTTAAATTTTTAC -3′ 
               
               
                   
               
               
                 275 
                 5′- GTACATCCCATATTCCCTTT[G]CAAAATCTAGTTTCCTATGT -3′ 
               
               
                   
               
               
                 276 
                 5′- GCTTACCAGAAAACACCCTC[G]TTGTTGTTTTTATTTCTCAG -3′ 
               
               
                   
               
               
                 277 
                 5′- GGACAAGGAGGAGAAGCCCC[A]GGAGGTCACGGGAGTTCACT -3′ 
               
               
                   
               
               
                 278 
                 5′- GAGCAGCCATTTCGAAAGGC[A]GCAGAAGAGGAAATTAACTC -3′ 
               
               
                   
               
               
                 279 
                 5′- GCGAGGGGAAGTCATTTTTT[T]AATAACTAGGCTCTATTTGC -3′ 
               
               
                   
               
               
                 280 
                 5′- CAAGGAAAGACCTGGTGTCC[T]TGTGCTAATTTTAACTCTCT -3′ 
               
               
                   
               
               
                 281 
                 5′- TACAGATGCTCATAGGCATC[C]GAAAAAAAAATACTTTGTTA -3′ 
               
               
                   
               
               
                 282 
                 5′- AACTCCTTTGACAGTATGGA[C]GGCACCTAACGCATCCTTGT -3′ 
               
               
                   
               
               
                 283 
                 5′- GAGGTGTTTTCTTGGCTCTT[A]ACKAACGTTTTTAATAAAGC -3′ 
               
               
                   
               
               
                 284 
                 5′- GCGCCCCCTGGACTTCTGCT[A]GAATTTAGATTTAAATAGAT -3′ 
               
               
                   
               
               
                 285 
                 5′- ACATATTTAGAATGGATGCC[G]GAACAGGAGAAATGGGTGGG -3′ 
               
               
                   
               
               
                 286 
                 5′- ATTCATATGCCACCAGCCAT[C]GGCAGAAATGTAACAGGAAA -3′ 
               
               
                   
               
               
                 287 
                 5′- ATGGCTCTGTAAATGGGATG[C]CTCATGTTCAGGTTTCTGGA -3′ 
               
               
                   
               
               
                 288 
                 5′- ATCTCCAGGTGAACATGGAA[C]GCAGTGAAAACCTGGGGTAT -3′ 
               
               
                   
               
               
                 289 
                 5′- TGATAAGTAGTTAATGATCC[T]GAAATAAACTGTTAGGTGCT -3′ 
               
               
                   
               
               
                 290 
                 5′- AAGTAAAATAGTAGATATTG[C]ATTGCTTCTACATTTACTAC -3′ 
               
               
                   
               
               
                 291 
                 5′- AGAGCCCCTACCCAATTGCT[C]TACTATTTATAGTTCCTCAG -3′ 
               
               
                   
               
               
                 292 
                 5′- ATCTGGGGACCTGCTCCTGG[T]AGAGCAATAGGAWCTGTGTG -3′ 
               
               
                   
               
               
                 293 
                 5′- GAGTCCCAAAATTCAACCCT[C]CCGATAGGGCTGGGCCTGAC -3′ 
               
               
                   
               
               
                 294 
                 5′- CCCTAGCCTGCTTTTGTCCT[G]TTATTTTTTATTTCCACATA -3′ 
               
               
                   
               
               
                 295 
                 5′- AGAGGGAACCCAAATATTAG[G]GTGGGAAGCAAGTCATAAAC -3′ 
               
               
                   
               
               
                 296 
                 5′- TAGGGTTACCAATCCACTAG[A]ATGCAAAACTGTACTTATTA -3′ 
               
               
                   
               
               
                 297 
                 5′- AGGCTTCTTTTTCCATTACA[C]TGTAAGACTTTGGAGGGCAG -3′ 
               
               
                   
               
               
                 298 
                 5′- AGCRGTCAGGTGCGGAGGCA[G]CCTCTCAGCGGTGGGGAACA -3′ 
               
               
                   
               
               
                 299 
                 5′- CAGGACAAACAGTGGATTCA[C]TCAGAACACAATATGCTGGT -3′ 
               
               
                   
               
               
                 300 
                 5′- AAGCCACTACAGACACCGCA[C]GCACCGAAATTCTCCCTTGT -3′ 
               
               
                   
               
               
                 301 
                 5′- ATCACTGTCCCTCAGTTCAC[C]GGTCTTGTCTGCTTCGTCGY -3′ 
               
               
                   
               
               
                 302 
                 5′- AATTCTCAGTCTTAAAAACA[A]GGCATAAAGAAAGCTAAAAT -3′ 
               
               
                   
               
               
                 303 
                 5′- AGAAGATAAGTGTTTAGGGT[G]TTGGATATCCCAGTTACCCT -3′ 
               
               
                   
               
               
                 304 
                 5′- CCTTTTTTTGGATGATCCTA[C]AATTAATACAAGTGTATTCT -3′ 
               
               
                   
               
               
                 305 
                 5′- GCCCTTAGTCACCAACTCCT[T]CTCATCCCACCATGCTGTTG -3′ 
               
               
                   
               
               
                 306 
                 5′- GTAAATTAAAATTTGTTTGG[C]TGATTTGTGCTGTATTTCTA -3′ 
               
               
                   
               
               
                 307 
                 5′- AGCAACACTTCCTCCTTGCA[G]ATTACAAGCATAGCTAATGC -3′ 
               
               
                   
               
               
                 308 
                 5′- CCCTCATTTTCTGTTAGGGA[T]GTATGTGTTTACCAAGCTGT -3′ 
               
               
                   
               
               
                 309 
                 5′- ATGAGGGCTTTACTTTTGCA[G]GAAATACTACAGATGGTGAA -3′ 
               
               
                   
               
               
                 310 
                 5′- TCCCTTCTCAGTAACTAACA[T]TAATCATCTCTCTGGAGGAC -3′ 
               
               
                   
               
               
                 311 
                 5′- CATTCCCTCACACAGTACAG[T]TTAATAAATGTGCATTTTGA -3′ 
               
               
                   
               
               
                 312 
                 5′- CCTGTGTGATGAGGGGCAAA[G]GAAGCTCTTGAGAACCTGCT -3′ 
               
               
                   
               
               
                 313 
                 5′- GTAACGAAGAAAGACCAGAG[T]GTCATCCCTGTGATACAGCA -3′ 
               
               
                   
               
               
                 314 
                 5′- TATGTATCTTGCTTTTGTTT[A]AAACAGTCATCCACATTAGT -3′ 
               
               
                   
               
               
                 315 
                 5′- GATAGGTTGCAAAATTTTGG[C]GTGTTCTTGCATTGCATACA -3′ 
               
               
                   
               
               
                 316 
                 5′- ATTGACGGTGTTATAATTAC[C]ATGGTTTTGAAATTACATAG -3′ 
               
               
                   
               
               
                 317 
                 5′- TGAGGACCCAGATGTCAACA[C]CACCAATCTGGAATTTGAAA -3′ 
               
               
                   
               
               
                 318 
                 5′- CTCCTTTTGACCTGAGTGTC[A]TCTATCGGGAAGGAGCCAAT -3′ 
               
               
                   
               
               
                 319 
                 5′- TATGTAAAAGTTTTAATGCA[C]GATGTAGCTTACCGCCAGGA -3′ 
               
               
                   
               
               
                 320 
                 5′- GATGGATCCTATCTTACTAA[C]CATCAGCATTTTGAGTTTTT -3′ 
               
               
                   
               
               
                 321 
                 5′- AATTAGCTGCCAGAGTTGCT[G]TCAGTAAAGAGAAGAAATAA -3′ 
               
               
                   
               
               
                 322 
                 5′- CTGAAATCAGAGAACATTGA[A]AGATGAAGTGAATGGCAGAG -3′ 
               
               
                   
               
               
                 323 
                 5′- GCCCATCTGAGGATGTAGTC[A]TCACTCCAKAAAGCTTTGGA -3′ 
               
               
                   
               
               
                 324 
                 5′- GTGCAGAYCAGATAATTATA[C]AGAGATGGAATGGGACAACC -3′ 
               
               
                   
               
               
                 325 
                 5′- AATCTGCCTCTGGGGCGGGA[T]CTGTCAGGCTTCAGGAAGGG -3′ 
               
               
                   
               
               
                 326 
                 5′- TCCAGGGAGGAGCTTCGTGC[G]ACCTTCCCGGACCACTCAGG -3′ 
               
               
                   
               
               
                 327 
                 5′- CATCACCTCCAGGTAGCTCC[T]AAAATGTCCCTAGAAAGTGG -3′ 
               
               
                   
               
               
                 328 
                 5′- GGAGCACAGAGTAGCAGTGA[T]GCTGTCCAAGGCAGGGGGGA -3′ 
               
               
                   
               
               
                 329 
                 5′- CATTCAGGCCAGTGGCTGCA[G]GGGAGCAGAAAGATCAGGCT -3′ 
               
               
                   
               
               
                 330 
                 5′- TACAGAGGAAGAAATCCAGG[G]CAGAGGTGGAGGCAGTGAAG -3′ 
               
               
                   
               
               
                 331 
                 5′- CTACCTCATTCATTGACCCC[A]CTATCTGACCTGTACATGTT -3′ 
               
               
                   
               
               
                 332 
                 5′- TTGAGGACAAACAGAACATC[G]GTGAGTAAGTGGAATATTAG -3′ 
               
               
                   
               
               
                 333 
                 5′- TTCTTGTGTTCTTCCCTTTC[C]ATTTCAACTCTTCATCTCAG -3′ 
               
               
                   
               
               
                 334 
                 5′- GGTTTGTGTACCAGGATTGG[G]GACCCCTGATGTATAGTGTA -3′ 
               
               
                   
               
               
                 335 
                 5′- GAAGAGGATAGGTTTTTCTA[C]CTTAAACAAAATCTTCCTTA -3′ 
               
               
                   
               
               
                 336 
                 5′- GTTAGGCATCAGGCAACTAC[C]AAGGAGTATACGAGCATGCA -3′ 
               
               
                   
               
               
                 337 
                 5′- CACAGGGTAAATTTAGCCAC[T]GCAGCAGGAGCATGATATAA -3′ 
               
               
                   
               
               
                 338 
                 5′- GGCATGTGAAATAAGTTGGT[C]TAATTAGAGTGAAGCCCAGG -3′ 
               
               
                   
               
               
                 339 
                 5′- TGGATTGTGTGTGTGGTAAT[A]GGATTATTGTTATATTTAAA -3′ 
               
               
                   
               
               
                 340 
                 5′- CACGAGCATCTTGCTGTCTT[A]AATTAAGAAGTTAACTGGAC -3′ 
               
               
                   
               
               
                 341 
                 5′- TTGAAAGCTGAGTCATTTTC[A]TAATGGGTCAGAAAGACATT -3′ 
               
               
                   
               
               
                 342 
                 5′- TACATGACGCATGTATTTGT[G]AAAACCCACAGATCTATTAA -3′ 
               
               
                   
               
               
                 343 
                 5′- CTGAGAGTGCAGTGAACCTT[T]GTGTCTGTGATGGAAGAGGT -3′ 
               
               
                   
               
               
                 344 
                 5′- GCTTAGATGTGAGAGTTGAT[G]CCATAATAATAAAAGTTATT -3′ 
               
               
                   
               
               
                 345 
                 5′- TTGAACTCTATGTACCAAGT[T]TGAACACATTCCAAATATCC -3′ 
               
               
                   
               
               
                 346 
                 5′- GGTATTTTGCTACAGCAGCC[C]GAGCAAACTAATATATCATC -3′ 
               
               
                   
               
               
                 347 
                 5′- AAAGGCGGTCACCTGCAGGA[A]TAGCCATCTTTGGTCCTTTC -3′ 
               
               
                   
               
               
                 348 
                 5′- CCCCCAGGGGTGGTAACAAC[A]GCACGCAAGCACAGCCATTG -3′ 
               
               
                   
               
               
                 349 
                 5′- CCACACCTGGTGGACAGGAC[C]ACCGTGGTGGCCAGGAAGCT -3′ 
               
               
                   
               
               
                 350 
                 5′- GGTTAAAAAGTTCTCTACCA[C]GGAAGTTGGATAAAAGTAAC -3′ 
               
               
                   
               
               
                 351 
                 5′- AAATCAGAATCGAATTATTG[G]TTTGGGGCTAATTGTATCTG -3′ 
               
               
                   
               
               
                 352 
                 5′- CCTGTCAGTGAAAACAACTA[C]CAAAGCTGGATTTTAAATAT -3′ 
               
               
                   
               
               
                 353 
                 5′- CCATTAGCAGTAGGTCTGAA[T]TAACTTTAATATGCAAGTTA -3′ 
               
               
                   
               
               
                 354 
                 5′- AGAGCCAGCTGGGAGAAACA[T]GCAACATAGTTCTTTGCAAT -3′ 
               
               
                   
               
               
                 355 
                 5′- AGCAGCTGGACCATGATCTC[C]TGGATATGGTGGTAGGTGAA -3′ 
               
               
                   
               
               
                 356 
                 5′- AGACGATGTACTGATGTAAG[G]TTTTGTAAATTTCTAAACTG -3′ 
               
               
                   
               
               
                 357 
                 5′- ACTCTGTCTTTCCAATTCCT[C]AACAGCATGCTTGGATGGGA -3′ 
               
               
                   
               
               
                 358 
                 5′- TCAGAAAGAATGGGGTAAGG[T]GAATTGAGTTTTAGAACATA -3′ 
               
               
                   
               
               
                 359 
                 5′- ACAGTGAAGAAAGAGGAACA[T]AGAGAAGGGCAGGCAGGAGG -3′ 
               
               
                   
               
               
                 360 
                 5′- TTGAAGGTGGATGAGGGAAC[G]GTCAGGTTGAGGAGCATTTT -3′ 
               
               
                   
               
               
                 361 
                 5′- ACACAATACTGGGTTTCTCT[T]CTTCTCTCTCACCATCACAC -3′ 
               
               
                   
               
               
                 362 
                 5′- CCACGCACCAGCAGGTTCAC[G]GTGCAGCTCATGCGGTTGTC -3′ 
               
               
                   
               
               
                 363 
                 5′- GATAGTCTAAATGAATGTCC[C]CCACCCCCGCCTGTAGTTGT -3′ 
               
               
                   
               
               
                 364 
                 5′- GCTGGCTGGGGCAAAGGTCT[C]TGATGCACTGTGCAGAAGTA -3′ 
               
               
                   
               
               
                 365 
                 5′- CTGCTCGGGCCAGAAAATCC[G]GAAACGGGCCCTTACCGATG -3′ 
               
               
                   
               
               
                 366 
                 5′- GTTCTGAAATGAAGACACAT[A]TGGCAGGCAGGTTACAACCC -3′ 
               
               
                   
               
               
                 367 
                 5′- CTCACTCACTCCTTGAGGAC[C]CTCTCATGACAACTGTAAAG -3′ 
               
               
                   
               
               
                 368 
                 5′- TTCAAAAACTATTTTGGTAC[C]TTTCAAATACAGTGTTTAAA -3′ 
               
               
                   
               
               
                 369 
                 5′- TGTTGCTAAGATCAATAGCT[G]CATTTGAATCTATGTCTCCC -3′ 
               
               
                   
               
               
                 370 
                 5′- CAGTTTATTATGGGTTATCT[C]ATTGGAATAAAGAGGTATCA -3′ 
               
               
                   
               
               
                 371 
                 5′- AATCATTATGTCACAAAAAA[T]TATATAAAGATAAATTTTTC -3′ 
               
               
                   
               
               
                 372 
                 5′- AGAGCCAAGACTTGTCCCCT[A]TTTCTGCAGCAGATTGGTCC -3′ 
               
               
                   
               
               
                 373 
                 5′- GTTTCTCAAAAGTTCTAAAC[T]TTACAGAGGATAATTTTAAG -3′ 
               
               
                   
               
               
                 374 
                 5′- CCTTGTCTGGACGAGTTGGG[G]TTCCTCAATAATTGGCTGTG -3′ 
               
               
                   
               
               
                 375 
                 5′- GGATCCAAAGGGTGTCAAGG[C]GATCATTATCTTGGGATGGA -3′ 
               
               
                   
               
               
                 376 
                 5′- AATGAAACTAAATGATCATC[C]TTCAACTCTCCCTTCTCACT -3′ 
               
               
                   
               
               
                 377 
                 5′- AGTTGCTCCCCTCTCTGATC[C]ACATTCGTAAAATGACATAA -3′ 
               
               
                   
               
               
                 378 
                 5′- CAGGTGTCCCTACCTTAAGG[T]CCTCCTCCTTGGGACTTCAG -3′ 
               
               
                   
               
               
                 379 
                 5′- CACACAACTRGCTAAGGAGC[T]CCAGGGCCACAGCTGCTGTT -3′ 
               
               
                   
               
               
                 380 
                 5′- ATAAGCAGGAAAATGAATGC[G]TTAGGAGAGGTTTTATATCT -3′ 
               
               
                   
               
               
                 381 
                 5′- TTATGCATACAACACTCAAC[A]GATCCAGTTACTCTIACTCT -3′ 
               
               
                   
               
               
                 382 
                 5′- CACCCCAGTCACCGTGGCTT[G]CACCTGCACAACAGATTCCT -3′ 
               
               
                   
               
               
                 383 
                 5′- AATTTCCCTGCATTTTGTGA[C]GACTTGTTTTTATTGGTAAC -3′ 
               
               
                   
               
               
                 384 
                 5′- TGCGCATTTTCCGCACTCGG[A]TACACTTTACACTGAACACC -3′ 
               
               
                   
               
               
                 385 
                 5′- GACCCAGAGCAGGAAGCATA[G]TCAAGCCCTCGACTAGATTA -3′ 
               
               
                   
               
               
                 386 
                 5′- CACTTGGAAATCCTAACTCC[A]CAGAACAAAATTTTACAAGC -3′ 
               
               
                   
               
               
                 387 
                 5′- ACACACTGACATTCGAGGCC[A]AAGGAATACTCCTGCCTCTA -3′ 
               
               
                   
               
               
                 388 
                 5′- TTCATTTACAAGCCTGATCA[C]CCTTACATGAACTAATGTTT -3′ 
               
               
                   
               
               
                 389 
                 5′- AACACTGTTGCAGGATCTCT[G]ATAATCACTATGTACACTTC -3′ 
               
               
                   
               
               
                 390 
                 5′- AACTCCCCAGCTAAACACCC[G]TAAGACTTCATACAACACAA -3′ 
               
               
                   
               
               
                 391 
                 5′- TAAATGCTTATCCATTTAGT[A]ACAGGAAAAATGAGACAACT -3′ 
               
               
                   
               
               
                 392 
                 5′- GTATGCTTTCCATCGAAAAA[T]TACTCTATTAAACAGCTTAG -3′ 
               
               
                   
               
               
                 393 
                 5′- TATACAGGAGTCATCCCCTA[C]GTTGACACTGGTAAGTTGTA -3′ 
               
               
                   
               
               
                 394 
                 5′- TCAAGTTTAAGCTGCTATGT[T]CCTTATTTTTAACTTTTGTT -3′ 
               
               
                   
               
               
                 395 
                 5′- ATATAATTTATATTACAATG[G]AAAAGCTTCTTTAATACTAA -3′ 
               
               
                   
               
               
                 396 
                 5′- GATGGGGAGGAAGAGAAGGC[G]TTGGTCTTGCAGTCTTGTCT -3′ 
               
               
                   
               
               
                 397 
                 5′- AATGGTAAGCATCTATTTTG[T]AGTCCACTCTACTGAGCTAA -3′ 
               
               
                   
               
               
                 398 
                 5′- TTTATATATGATATCATCAT[A]AAGCACTTTCTATAAGCTGA -3′ 
               
               
                   
               
               
                 399 
                 5′- AACAATCTGTGAACACTTGT[T]ATATGCTTACTGTAAGTGTG -3′ 
               
               
                   
               
               
                 400 
                 5′- ACTATATGTCATGTCTACAG[T]CTGTCTCCTAAGAGTAGAGG -3′ 
               
               
                   
               
               
                 401 
                 5′- TGCAAACATTGGGAAACCAC[G]GTAGGGGGGAGCAGGACTCT -3′ 
               
               
                   
               
               
                 402 
                 5′- TACCATGGACAGCAGCGCTG[C]CCCCACRAACGCCAGCAATT -3′ 
               
               
                   
               
               
                 403 
                 5′- ACTTGTCCCACTTAGATGGC[A]ACCTGTCCGACCCATGCGGT -3′ 
               
               
                   
               
               
                 404 
                 5′- GCATTTCACATTCACATGTA[G]TATTTGAATATACACATCAA -3′ 
               
               
                   
               
               
                 405 
                 5′- TTGAGTCTCCTTCCAATTAA[C]TCATGGAACATCAGAGCCAT -3′ 
               
               
                   
               
               
                 406 
                 5′- TCTTTTGTGGAAATGTGATG[C]ATTTGTTTATATGCAGACAA -3′ 
               
               
                   
               
               
                 407 
                 5′- ACCAGACTTAGGAGAGATAT[A]TCTCACTGTAGAACCAGTGC -3′ 
               
               
                   
               
               
                 408 
                 5′- CTCTGGTCAAGGCTAAAAAT[C]AATGAGCAAAATGGCAGTAT -3′ 
               
               
                   
               
               
                 409 
                 5′- AGCCAAAGTTCAGTTCTCCA[G]TTCATCTGAGCTCAGGCCCA -3′ 
               
               
                   
               
               
                 410 
                 5′- GGTATCRTGGGTCCTTTCRAGTAC[T]AACCGCCTTAGGCTGGAAGC -3′ 
               
               
                   
               
               
                 411 
                 5′- TTTTACCGAAGGCTGTGTCT[T]GTAAGCACCCCCGAGCAACT -3′ 
               
               
                   
               
               
                 412 
                 5′- CTACTCCGGCACCCAGTGGG[T]TGGTAGTCCTGTrGGCAGGA -3′ 
               
               
                   
               
               
                 413 
                 5′- CCAAGAAGCGCGCGGCGAGA[G]TGCAAGGTGGGGGCCCCGCC -3′ 
               
               
                   
               
               
                 414 
                 5′- CTCTCGCCGCGCGCTTCTTG[G]TCCCTGAGACTTCGAACGAA -3′ 
               
               
                   
               
               
                 415 
                 5′- GAGCAGAGGGGCAGGTCCCG[A]CCGGACGGCGCCCGGAGCCC -3′ 
               
               
                   
               
               
                 416 
                 5′- AGAGCGGATTGGGGGTCGCG[T]GTGGTAGCAGGAGGAGGAGC -3′ 
               
               
                   
               
               
                 417 
                 5′- TGGGGATTCAGAGCACCCAC[G]CGCAGCACCTCCCTCCTCTG -3′ 
               
               
                   
               
               
                 418 
                 5′- GGGTCAGTCCGGACAGCCCC[A]GTCGCTTGTTACCTAGCATC -3′ 
               
               
                   
               
               
                 419 
                 5′- CTGGGTGCGCTGGCCGAGGC[G]TACCCCTCCAAGCCGGACAA -3′ 
               
               
                   
               
               
                 420 
                 5′- GACATGGCCAGATACTACTC[G]GCGCTGCGACACTACATCAA -3′ 
               
               
                   
               
               
                 421 
                 5′- CTGACAATGTCTGTGGCAAC[C]CTGCAGTTTACTCCTTGGTT -3′ 
               
               
                   
               
               
                 422 
                 5′- CAGACACCCACTCCTATGTG[T]GTTTCTGAAAATTACAGGGT -3′ 
               
               
                   
               
               
                 423 
                 5′- TCCAGATATGGAAAACGATC[C]AGCCCAGAGACACTGATTTC -3′ 
               
               
                   
               
               
                 424 
                 5′- ATTTCAATTTAGAGTCAGGG[T]CTCACTCTATGCTCCCCTGA -3′ 
               
               
                   
               
               
                 425 
                 5′- TGGAAAGAGGTGCCCACCAA[T]GTCTAAGTGTTAAACATTGA -3′ 
               
               
                   
               
               
                 426 
                 5′- TATCATGCATTCAAAAGTGT[A]TCCTCCTCAATGAAAAATCT -3′ 
               
               
                   
               
               
                 427 
                 5′- TGAAAAATCTATTACAATAG[T]GAGGATTATTTTCGTTAAAC -3′ 
               
               
                   
               
               
                 428 
                 5′- TATTTCTCAAACATTTTCAG[G]TTTAGAATGGGAATAGGTTT -3′ 
               
               
                   
               
               
                 429 
                 5′- GTGCCTTTAAACCTATTCTA[A]AACCTATTTAAACGTATTTC -3′ 
               
               
                   
               
               
                 430 
                 5′- AGGGCTGCCTGGTAAGCTGA[A]TCAGGGTGCCTGGCTGCCGC -3′ 
               
               
                   
               
               
                 431 
                 5′- AACGCCACTTGTGACTGCTC[G]TTACCTTTCAGTTGTGTCCC -3′ 
               
               
                   
               
               
                 432 
                 5′- ATGTTGGGATTTAACTTTCT[G]TTATATGTCAGACTCACTTA -3′ 
               
               
                   
               
               
                 433 
                 5′- TGTGTGTTTTAAATCTTTGC[G]CTTAAATGTTTTTGATTTCT -3′ 
               
               
                   
               
               
                 434 
                 5′- GAAGCTTCCCTCCGACAGGC[G]GCCCCGCACTAAGGTAGGGA -3′ 
               
               
                   
               
               
                 435 
                 5′- CTAATGGTTGGAAACGCCAG[C]CTTTGGTGAAAACAGAAAGT -3′ 
               
               
                   
               
               
                 436 
                 5′- TTCAAGAATTCAACTGCAGA[T]TGAAAATATTTGGAGAAAAA -3′ 
               
               
                   
               
               
                 437 
                 5′- AACCTAGCCACAGAGCCCGA[T]GCGATGTGTCCTTGTCGAGA -3′ 
               
               
                   
               
               
                 438 
                 5′- GCCTCCTTTGCTGCCCTCAC[A]ATCTCTTCCTGTGACACCAC -3′ 
               
               
                   
               
               
                 439 
                 5′- CTCTGCACCTTCAGGTTCAG[G]CCCTTCAAGATCTACCAGGA -3′ 
               
               
                   
               
               
                 440 
                 5′- ACAAGCTAGTTACCTTTTAT[T]GTTCAGTTTAAAAAAGTTCT -3′ 
               
               
                   
               
               
                 441 
                 5′- CGGTCCCCTTCAAGATCCAT[C]CCGACCTGAAGAGAAACCGC -3′ 
               
               
                   
               
               
                 442 
                 5′- TGCTCTTCAAAAAAACCAGA[C]TGAATATTTTTAAAAGTAAT -3′ 
               
               
                   
               
               
                 443 
                 5′- GTTACTTGTAGGGGGAGGGT[G]GAGGGAAATCTGGGCAAATG -3′ 
               
               
                   
               
               
                 444 
                 5′- GGGCTTCTATCCCCGAACCC[T]GGGCCCTGGTGCCACTCAAG -3′ 
               
               
                   
               
               
                 445 
                 5′- TCCCAYTTAAGAGCTATTCT[C]CTATCCTTCCCTGTAAACAA -3′ 
               
               
                   
               
               
                 446 
                 5′- TGGCAGACACAGGACAGGGA[T]CGCTGCTTATGTCTCCGAGG -3′ 
               
               
                   
               
               
                 447 
                 5′- AACCCATCCTCGTGGTAATC[A]TCCCTGGTAAGAAACACACA -3′ 
               
               
                   
               
               
                 448 
                 5′- CATTTCTAATTACCAGCTTC[C]TACTTGGCACTTTCAATTTT -3′ 
               
               
                   
               
               
                 449 
                 5′- CCACAGCGGCTTCCTGCCAT[C]GATGAGGCTGATTTCTGCCT -3′ 
               
               
                   
               
               
                 450 
                 5′- TGCATCCTCTGCTTCTCCTC[A]AACCGTGCTTCACAGCTGCC -3′ 
               
               
                   
               
               
                 451 
                 5′- GGGGCCAAAGGAATATTTAG[G]TGAAGGGGGAGAGAGGCCAC -3′ 
               
               
                   
               
               
                 452 
                 5′- ACTTTGTGTGTACATGTGGA[A]GGAAGTATTTGACATTTTGA -3′ 
               
               
                   
               
               
                 453 
                 5′- ACTTGTGTCCCCCAAAATCA[C]ATATTGAAGTTAAAACCTCC -3′ 
               
               
                   
               
               
                 454 
                 5′- TAGCCATGGCAGAAGACATA[T]TCTCTACACCTTATGCATGG -3′ 
               
               
                   
               
               
                 455 
                 5′- GACAGAGAAGGTATGTCCAC[A]CACACTAGACATACTGCATG -3′ 
               
               
                   
               
               
                 456 
                 5′- AGTATTGATCAGTGGCGGGA[T]ACAGTTTGAAGGTAGAGGGA -3′ 
               
               
                   
               
               
                 457 
                 5′- GCTGTATCTTGGGGGAAGTG[C]GTTCTTGAGAGCTGTGTAAG -3′ 
               
               
                   
               
               
                 458 
                 5′- GGCCGTCCTCATCTTCACAC[G]CTGTTCTCCTTCTATGTGGG -3′ 
               
               
                   
               
               
                 459 
                 5′- TAGCAGGTGGCACAACTGGC[A]CTGGGAACCGGGGGTCCCTT -3′ 
               
               
                   
               
               
                 460 
                 5′- GGCCCCCCGTGCAGGGAGGG[C]TTCAGGCTGCGGCAGGTAGG -3′ 
               
               
                   
               
               
                 461 
                 5′- TACTATACAAATAAAAAAAT[A]AAAACCCAACCTCAAGCTGT -3′ 
               
               
                   
               
               
                 462 
                 5′- CGAATGCTGAGAACTTGCCA[C]GCTCTCTCCCCAGGGCCCCA -3′ 
               
               
                   
               
               
                 463 
                 5′- GCCTCCCCCTGTGATCTCTC[A]GTCCTCTCCGCATTCCTGGG -3′ 
               
               
                   
               
               
                 464 
                 5′- TTCCCTTTGTTTTCCCTTTC[C]TCCAGCTCCAGGCCAGGCTT -3′ 
               
               
                   
               
               
                 465 
                 5′- TGCGCTCTGGGCTAGACACT[G]TGATAGGTGCTGGGATTACA -3′ 
               
               
                   
               
               
                 466 
                 5′- TGGAAAACAGATCCAGACAG[G]TTCAGTTATGTGTCTGAGAA -3′ 
               
               
                   
               
               
                 467 
                 5′- CCCTACTACCCCTACAACTA[C]ACGAGCGGCGCTGCCACCGG -3′ 
               
               
                   
               
               
                 468 
                 5′- GCATGCCTTTTCAAAAACAC[A]TTCAAGACCTGAAAATAAAA -3′ 
               
               
                   
               
               
                 469 
                 5′- TACTGCTGTGGCCTGAATCC[G]TGATTAAAGGAAATGCTAAG -3′ 
               
               
                   
               
               
                 470 
                 5′- TACACAAGTCACTGGGTGAC[A]TCTGTAGCTCCACCAACCTG -3′ 
               
               
                   
               
               
                 471 
                 5′- CTCTGTCTAGGTGCATAGAA[T]TGTGTACATATACATACACA -3′ 
               
               
                   
               
               
                 472 
                 5′- AGTCTGCAAATGTGTTTTTT[G]TGTGCTAAATAGCTCAAAGT -3′ 
               
               
                   
               
               
                 473 
                 5′- TAAGTTTGGTTGATGAGTCT[G]TCTCTCTAGACTGCAAGCTC -3′ 
               
               
                   
               
               
                 474 
                 5′- CACAGAAGTGGGCATTCTGA[G]AGGCCTCTAATTTTCCTCTA -3′ 
               
               
                   
               
               
                 475 
                 5′- TTAAAACAGCGACCCCATAC[A]TGCATTAGTTAAAACTTTCT -3′ 
               
               
                   
               
               
                 476 
                 5′- GCAGATTGAGGTAAATTCAT[T]GTTAATGTCATCACAGCAAT -3′ 
               
               
                   
               
               
                 477 
                 5′- CAAAACAGAATCCCAAGAGC[A]ATATTTTAACTCAACAAACA -3′ 
               
               
                   
               
               
                 478 
                 5′- AGAGTTCTTATGGTTCTCTT[C]GGTAGTTTTTCTTTAGCTGG -3′ 
               
               
                   
               
               
                 479 
                 5′- CTTTCATTCTTGTCGTTGGC[G]TCTCTGTTCTGATAAAAAGA -3′ 
               
               
                   
               
               
                 480 
                 5′- GGAGGCAATGTCTGATTTGC[G]TAGGGCTCAGGGGAGAGATG -3′ 
               
               
                   
               
               
                 481 
                 5′- AGGTTCAGCAGAAAAGAACC[T]AGGAAAAAAGTCTAGGAAAG -3′ 
               
               
                   
               
               
                 482 
                 5′- GATGGGCCTTCTGATAAGGA[A]CGCTGCCAAAAGTTCAAATG -3′ 
               
               
                   
               
               
                 483 
                 5′- ATTCCTTCCTTTCCCTGTTT[A]TACATACCTTACAGATACTG -3′ 
               
               
                   
               
               
                 484 
                 5′- TCTGTTTCAGTCTCAAGGAG[G]CTGAAAAGGTGAATTCCTGT -3′ 
               
               
                   
               
               
                 485 
                 5′- CAGTCTTGTGAGAACATTCT[T]GCCATCTGTACTTTGCATTT -3′ 
               
               
                   
               
               
                 486 
                 5′- CCACACCTGGCCTGAACTCT[G]CTTTAAAAACTGCATGCTGA -3′ 
               
               
                   
               
               
                 487 
                 5′- TCATGCATAGATGGTGTAGC[A]TTAGAAAACTCAGGCCTAGC -3′ 
               
               
                   
               
               
                 488 
                 5′- AGGTGGATTTTTTTAAGAAG[C]ATATTCATACAACTGAATAT -3′ 
               
               
                   
               
               
                 489 
                 5′- GCCTGATATTCTTTCCCTAT[G]AAATTGCTTCCTCATCTAGG -3′ 
               
               
                   
               
               
                 490 
                 5′- GAAGAAGCTGTCAGAATTGC[A]AGGGAAATTGGTAAGTCCTT -3′ 
               
               
                   
               
               
                 491 
                 5′- ACTGTGCCCACCCAAGTTTG[T]GTTTTGAAAAGATTGGTCAA -3′ 
               
               
                   
               
               
                 492 
                 5′- ATGGCATACAGCCTGGGTGA[T]ATTTTTAAACATAAGTGAAA -3′ 
               
               
                   
               
               
                 493 
                 5′- GGGAAAATGTTCATTTAAGT[A]TAAAACATGAAATGGTATTC -3′ 
               
               
                   
               
               
                 494 
                 5′- CTTGTTAGTTCAGGTCTCTT[T]CAGATGAGGAAGACAGATTA -3′ 
               
               
                   
               
               
                 495 
                 5′- AAATGGACAACAAAAGTCAC[C]GGAAAAAAGGGAAAAAAAGA -3′ 
               
               
                   
               
               
                 496 
                 5′- TGAGAAATAAGTGATGTCAT[G]CATTTTTGGTTGTGGATCAT -3′ 
               
               
                   
               
               
                 497 
                 5′- TGTGGTTCTCCCTTCACAGT[G]GAATACAAGGGCTTTTATAT -3′ 
               
               
                   
               
               
                 498 
                 5′- TAATAAGTGGTTATGCCAAG[C]GGTCCCTGCAGCTCAGAGGC -3′ 
               
               
                   
               
               
                 499 
                 5′- TCTTTGGGCCTCCACCCCCT[C]GTCTCTAGTGGACATTTGAG -3′ 
               
               
                   
               
               
                 500 
                 5′- AAAGGAAGCTGGGCGTCCTC[C]GGGCCCCCCAACACACGTCC -3′ 
               
               
                   
               
               
                 501 
                 5′- CTAACACAGTTGCGAACATC[G]GCAGAGCCCTCGGGAGCCAC -3′ 
               
               
                   
               
               
                 502 
                 5′- TTGATGATGATGTCGATGCC[G]AAGAGTGACACGCCCAGTGC -3′ 
               
               
                   
               
               
                 503 
                 5′- CTTCACAGCGCCGCAACAAT[C]ATGCATGAGGGAGTGATTCG -3′ 
               
               
                   
               
               
                 504 
                 5′- GGCCACAGCTGGCCAGTCTC[C]TTGTGCTTTGAATCTCCAGC -3′ 
               
               
                   
               
               
                 505 
                 5′- TGCAGCGTGCGGCAGTGCTT[T]GTTCTTCTTTAAGATGAAAT -3′ 
               
               
                   
               
               
                 506 
                 5′- CCTACACAGGAAGCCCCGGA[G]CCACAGCAATTCTCCCTGCC -3′ 
               
               
                   
               
               
                 507 
                 5′- TGTGCTCTGGCCAGGGGCCT[G]GACCTCATTCTGTTGGTGGT -3′ 
               
               
                   
               
               
                 508 
                 5′- TCGCCCAGGCTGACCACAAG[C]TCCAAACAGGACTTTCTTGT -3′ 
               
               
                   
               
               
                 509 
                 5′- TGCCCAAACAGTATCAAAAG[T]GGATGTTTATCACAATACTA -3′ 
               
               
                   
               
               
                 510 
                 5′- TTAGCAACAAAATCCTGAAG[T]CACTTCTAGACCATAACCCA -3′ 
               
               
                   
               
               
                 511 
                 5′- CAGAGGGCAGGGCCCACACC[G]TACCCCACAGAAGCCCAGGA -3′ 
               
               
                   
               
               
                 512 
                 5′- GGGTACAGCCCAGCATGGCC[G]CAGGGGTCCCTGATGGGAAT -3′ 
               
               
                   
               
               
                 513 
                 5′- GACTGCCAGGTGTGGACACA[T]GCTCGTCAAGTGGTGAAGAA -3′ 
               
               
                   
               
               
                 514 
                 5′- CACACGGACGCTTCCTCCTA[T]GTGAAGTTCTGTTTCCTCCC -3′ 
               
               
                   
               
               
                 515 
                 5′- ATGGTCATATTATGCATGCA[C]GTTTTTGATTTCAAGAATGC -3′ 
               
               
                   
               
               
                 516 
                 5′- ATGCGGTGCTCGGTAACTGT[G]CATCCGATGCAGGCCTCACT -3′ 
               
               
                   
               
               
                 517 
                 5′- ACCAGAATTATCACAGCACC[T]TCTCATTCCCAGCGCGTCCT -3′ 
               
               
                   
               
               
                 518 
                 5′- TGATCATGGTCACTGCCCTG[C]GTTCAAATAATGCGAGCTGA -3′ 
               
               
                   
               
               
                 519 
                 5′- AGGACAACATGCCATTTGTC[G]AAACGTTTTAAAGATATGAT -3′ 
               
               
                   
               
               
                 520 
                 5′- GGGGGAAGCTGGGTGCATGC[G]GAGCACCGTGGAGTCTGGGA -3′ 
               
               
                   
               
               
                 521 
                 5′- CCTTGAAGTCACCCGGCCCC[G]ATGCAAGGTGCCCACATGTG -3′ 
               
               
                   
               
               
                 522 
                 5′- TTTGGAAGGAAAACGTGGCG[T]GTGGGCGTATTCTCCAGAAG -3′ 
               
               
                   
               
               
                 523 
                 5′- TCCCAGACCAGACCTTGCCC[A]ATGACGTTGTTGGTAATGCT -3′ 
               
               
                   
               
               
                 524 
                 5′- TGAGATCCCCCGGACAACAC[A]CTCCACCTTCCCATGGAGCT -3′ 
               
               
                   
               
               
                 525 
                 5′- TTGTTTGTGTCTGTCTCAAA[C]CCAAAGGGGTGGCTCAGCCT -3′ 
               
               
                   
               
               
                 526 
                 5′- GAACCTCCCAGGGGGCAGAA[C]AAAAAGTCAACAAGCTGGAA -3′ 
               
               
                   
               
               
                 527 
                 5′- CAAACGTTGCTGAAGTCTCC[C]CGACCTTTATTGTTTTGCCC -3′ 
               
               
                   
               
               
                 528 
                 5′- GTTCCCTGACCAGGAGTCCA[A]TAGGCAATAGTCTATTAACT -3′ 
               
               
                   
               
               
                 529 
                 5′- TTTGCTCATGCACCTGCCTT[G]CCTTTGTCATCACAACAGAA -3′ 
               
               
                   
               
               
                 530 
                 5′- ACCTCCTTCCCCGTGCKCCA[C]GAGGAGCGGGCTGCACCTTG -3′ 
               
               
                   
               
               
                 531 
                 5′- GCTGAAACCCGATTCCTACC[A]GGTGACGCTGAGACCGTACC -3′ 
               
               
                   
               
               
                 532 
                 5′- TCCTGCTCGACCTGCTCCTC[C]AGCTGTGCAATCTTGGCCTC -3′ 
               
               
                   
               
               
                 533 
                 5′- TCCAGCGCCGCGATGGTGGA[C]TTGAACTTGGACTTGACGGC -3′ 
               
               
                   
               
               
                 534 
                 5′- TACGAGGAGAAGGCGGCCGC[G]TATGATAAACTGGAAAAGAC -3′ 
               
               
                   
               
               
                 535 
                 5′- TTCCGCAGCTTGAGGTAGGC[G]GCGCAGTTCCTCTGAATCAC -3′ 
               
               
                   
               
               
                 536 
                 5′- CCTGTGGCTGGTACCTTCCC[A]GCATAATGGATGATGGAGAA -3′ 
               
               
                   
               
               
                 537 
                 5′- ATGATTGCCATGGCCTCCAC[G]GTTTCCTGGAACATCTCATC -3′ 
               
               
                   
               
               
                 538 
                 5′- CCAGAACCACCAACATCTTC[A]GTCTCTGTATTCAATTTTAT -3′ 
               
               
                   
               
               
                 539 
                 5′- TTTTCCCAGCTGTAAAAGGG[A]GCTAATAATAGCTCTTGCGG -3′ 
               
               
                   
               
               
                 540 
                 5′- GATACCTGACTCCAGGAGCC[A]TCACTTTACAACCTGAGATT -3′ 
               
               
                   
               
               
                 541 
                 5′- TTCTTGCCCTTGTACATGTC[G]ACGATCTTCTCCGAGTAGAT -3′ 
               
               
                   
               
               
                 542 
                 5′- ATCATGCTCAGTGAAACAAA[C]CAGAAAGGCCACACGCTCTA -3′ 
               
               
                   
               
               
                 543 
                 5′- ACCTGGTCAACAGCTTCCCT[T]AGGATTTTACTGCCAAGCCA -3′ 
               
               
                   
               
               
                 544 
                 5′- CACCCAGTCTGACCTTCACT[T]TTTTGTTGATGGGGCTGAGC -3′ 
               
               
                   
               
               
                 545 
                 5′- GCTGCTGGGGGTGGGTGCTT[G]GATCCTGGTGAAATGGCCTC -3′ 
               
               
                   
               
               
                 546 
                 5′- AGAATCATCTTCTCCTTTCC[T]TCACCTGATACCCAGCTTGA -3′ 
               
               
                   
               
               
                 547 
                 5′- CCTGTCAGGCCTGACGGGGA[G]GAACCACTGCACCACCGAGA -3′ 
               
               
                   
               
               
                 548 
                 5′- GGCTATGAATATAGTACCTG[A]AAAAATGCCAAGACATGATT -3′ 
               
               
                   
               
               
                 549 
                 5′- CTTTTGGGAATTTCCTCTCC[C]CTTGGCACTCGGAGTTGGGG -3′ 
               
               
                   
               
               
                 550 
                 5′- CAAGCCATGGCAGCGGACAG[C]CTGCTGAGAACACCCAGGAA -3′ 
               
               
                   
               
               
                 551 
                 5′- GACCAGTGAACTTCATCCTT[A]TCTGTCCAGGAGGTGGCCTC -3′ 
               
               
                   
               
               
                 552 
                 5′- TCAGTATAGATGCACCCATC[G]TAAGCCTAACTACATTGTAT -3′ 
               
               
                   
               
               
                 553 
                 5′- GTGAGCGTGCCATCAGCCCA[G]TGGAGGGGCTTAGGTCTGCA -3′ 
               
               
                   
               
               
                 554 
                 5′- GGTGCCATCCAGTGCCCTGA[T]AGTCAGTTCGAATGCCCGGA -3′ 
               
               
                   
               
               
                 555 
                 5′- GGCCCGTAGCCCTCACGTGG[G]TGTGAAGGACGTGGAGTGTG -3′ 
               
               
                   
               
               
                 556 
                 5′- TCAGGCCTCCCTAGCACCTC[C]CCCTAACCAAATTCTCCCTG -3′ 
               
               
                   
               
               
                 557 
                 5′- AGCCATGAGTTTCCACCAGC[A]GCAGAGTGAGTCCTGAGCAC -3′ 
               
               
                   
               
               
                 558 
                 5′- ATTGCAGAGAATGGAAGAAT[T]TGAAGAACTGAGTGACAAGG -3′ 
               
               
                   
               
               
                 559 
                 5′- AGCTACTGGGTAGAATTTTA[C]GTAGTAACTAGGTAGACACT -3′ 
               
               
                   
               
               
                 560 
                 5′- GGATGGCATAGCGAGAATAC[T]AATCTAGGAAGCGACTGGAC -3′ 
               
               
                   
               
               
                 561 
                 5′- GCTTTCCTGCTATCATAGCC[G]ACTTAAGTAGCTGTATTAGG -3′ 
               
               
                   
               
               
                 562 
                 5′- ATGAGGAAGAGAGAGACGAG[G]TGGGGTGACTCATGCCTGAA -3′ 
               
               
                   
               
               
                 563 
                 5′- TTTCTTTGAGACAGGGTCTC[C]CTCTGTTACCCAAGCTGGRA -3′ 
               
               
                   
               
               
                 564 
                 5′- TCATTAGCAGGGTGATGGTG[A]GGCTGAGATGGGCAGGGCCA -3′ 
               
               
                   
               
               
                 565 
                 5′- ATTGCCAACATAGCTGTTCA[T]ACCTAGAACACCTTTTCCTT -3′ 
               
               
                   
               
               
                 566 
                 5′- CACAACCTCGGTAAGGCTGG[T]GATCTTCAAGCCAGTCCGAT -3′ 
               
               
                   
               
               
                 567 
                 5′- GTCCGTTGTCCACGTTCTAC[C]TCCACCCCACTAACTGAACG -3′ 
               
               
                   
               
               
                 568 
                 5′- AGGCCAGGGGTCTGGATGCA[C]ATAGCGTTCCCCTAGCCTCT -3′ 
               
               
                   
               
               
                 569 
                 5′- TGCAGAGGTGTGGGCCCCTG[G]GGACCCAGAAGTCCAGCCAC -3′ 
               
               
                   
               
               
                 570 
                 5′- GGGTGAAGTAAAGTGGGCAG[T]GTGATTTAGCAGAGTGGTCA -3′ 
               
               
                   
               
               
                 571 
                 5′- GGCACCTGTCATAGTCTTGC[C]GAAAGATGACAAGCCCTGGT -3′ 
               
               
                   
               
               
                 572 
                 5′- CGCAGCCCAGGATGATCTGT[A]CGGGACAGAGGCAGCGGCCT -3′ 
               
               
                   
               
               
                 573 
                 5′- TCGGAACAGCGAGTCCTCTG[C]CGTCGAGAGCAGGGAGGGGT -3′ 
               
               
                   
               
               
                 574 
                 5′- TTTGCCCAGTGACGCAGCAT[T]CCAGGCTGAGATTGCAGAAT -3′ 
               
               
                   
               
               
                 575 
                 5′- GCCCCCTCTGCAGGTCCCCT[C]GGTGTACTCTGAGGTGGGAA -3′ 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                 TABLE 5 
               
               
                   
               
               
                 (SEQ ID 
                 WT Sequence 
                   
               
               
                 NO:) 
                 (polymorphism location is indicated in brackets) 
               
               
                   
               
             
            
               
                   576 
                 5′- GGACACAACAGGACCCACTG[A]GGAAAACAATGATGACTTGG -3′ 
                   
               
               
                   
               
               
                   577 
                 5′- CCCCTCCACTTTGCTCACCC[G]TCTTCCGGGCCCTGAACCCA -3′ 
               
               
                   
               
               
                   578 
                 5′- TCCTGTGCCGGCTGCAGGTA[C]GGAACAAGTAGGCTAGTGTC -3′ 
               
               
                   
               
               
                   579 
                 5′- AGGAAAGACTGTTGGGCCTC[A]GAAAACATCCCACGTGCTAG -3′ 
               
               
                   
               
               
                   580 
                 5′- GGGACTTGGTTTCATGTCTC[C]ATCTCTCAGTTCTGTTTCCC -3′ 
               
               
                   
               
               
                   581 
                 5′- ATAGAGAGGGTCTGTTAGGT[G]CTTGGGATCTTGTTCTTCAA -3′ 
               
               
                   
               
               
                   582 
                 5′- ATTCCAATTGAAGATTGAAA[A]TGGCCTGTTTGGTAAACTGG -3′ 
               
               
                   
               
               
                   583 
                 5′- TAACTCAAAGCACAAAGTTT[A]GAATTCCTACATTCTAAAGA -3′ 
               
               
                   
               
               
                   584 
                 5′- GTCACCTGCCTCGGAGCCAG[C]TAGGCTGTTTAACAGTGCAG -3′ 
               
               
                   
               
               
                   585 
                 5′- GGAGCTTTGGCATCGCAGAG[G]CTTGAGCTGAGTCTGGCTCT -3′ 
               
               
                   
               
               
                   586 
                 5′- CAGAGCCCCTCCCTCTAAAC[C]CAGTCTTTCAAAGGGATTGT -3′ 
               
               
                   
               
               
                   587 
                 5′- CAATTTCTTGCTGAAAGCCC[C]GAGTTATGCCAGACACTGTG -3′ 
               
               
                   
               
               
                   588 
                 5′- ACCTTTGCCCAGATCCAAAT[T]TTTTTTCTTCATTCGAAGCT -3′ 
               
               
                   
               
               
                   589 
                 5′- ACGGATCTCTTACCATTAAA[C]TCAGGTGGAGAGGGAGTGCC -3′ 
               
               
                   
               
               
                   590 
                 5′- TTTCACAGATGAGGAGGCTG[A]CCTCAGGAAATGTGACTCAG -3′ 
               
               
                   
               
               
                   591 
                 5′- CCAACACCACCCCTTGCCCA[A]CCAATGCACACAGTAGGGCT -3′ 
               
               
                   
               
               
                   592 
                 5′- CCCATATCATGCAGAGGATC[C]GGGATTTCAATCCAGGTCTA -3′ 
               
               
                   
               
               
                   593 
                 5′- TGACGTGTGCAGAGAGACAT[G]TCAGCCTGCCCTGCACTTGT -3′ 
               
               
                   
               
               
                   594 
                 5′- GGCAGCATATTAGAAAATAG[T]TTATGTTACAACAAAAACCC -3′ 
               
               
                   
               
               
                   595 
                 5′- TGCCCCTTCTCACTGGTCTG[T]GGCTGGCAGGGCCATCTTTC -3′ 
               
               
                   
               
               
                   596 
                 5′- GAATCCATCCCAAGGACACC[A]TTTGAAAACATGAAATAACA -3′ 
               
               
                   
               
               
                   597 
                 5′- CAGCGGGGAGGGGAAAGGTC[C]GAAATGAGGGGAGAGACGTG -3′ 
               
               
                   
               
               
                   598 
                 5′- GCTGGGCAGAGCCATTCCTG[G]GCTGGCTGGGTGTGTTTGGG -3′ 
               
               
                   
               
               
                   599 
                 5′- ACAGGCATCAGGGATACAGT[A]GTGAACAAGCATACACAATC -3′ 
               
               
                   
               
               
                   600 
                 5′- AGGTGAAGCTGAGGCCTGAG[A]CCAGAAGGAGAGAAAAGGAA -3′ 
               
               
                   
               
               
                   601 
                 5′- CACTCATTAATCCATTAAAC[A]ATTAATCTATTAATCCATGA -3′ 
               
               
                   
               
               
                   602 
                 5′- GTGTATGCTGTGAAGAAGGC[C]ACCCCCCTTCCTGCCCATCC -3′ 
               
               
                   
               
               
                   603 
                 5′- CTGTCACTATGCCCCTGCCT[C]TCTCAGTGTCTATCTCTGTT -3′ 
               
               
                   
               
               
                   604 
                 5′- GGGATGACAGTGAGAGGAGG[G]CAACAGTAAAAGGAGTCATA -3′ 
               
               
                   
               
               
                   605 
                 5′- GTGTGTCTGTCAGGGAATGT[A]TCCCTCTTCCATTCTCTGTG -3′ 
               
               
                   
               
               
                   606 
                 5′- CCATTCTTGGTGGTGAGCCT[A]GACTCTGAGCCTGGGATGTG -3′ 
               
               
                   
               
               
                   607 
                 5′- GTCTGGCTGCCCCTTGGCCT[T]CACYACAGTCAGGTCCAGCC -3′ 
               
               
                   
               
               
                   608 
                 5′- TTGAGGATTAAAGAGCAGAR[A]TCATGTAGCATCTGGCACAT -3′ 
               
               
                   
               
               
                   609 
                 5′- CGTCATGTAGCATCTGGCAC[A]TGGGGGAACGCAATGGAAGT -3′ 
               
               
                   
               
               
                   610 
                 5′- CAGAGAATATTTCACATGCA[C]GTAGCAAAAACACCAGGGGT -3′ 
               
               
                   
               
               
                   611 
                 5′- AACATGGATTAATGTGGGAA[T]TTGGCTTCAAGAACACAACC -3′ 
               
               
                   
               
               
                   612 
                 5′- ATTATTTCATTTTAAAACCA[C]AGAATAAAAATGACACCTGA -3′ 
               
               
                   
               
               
                   613 
                 5′- AAGCAGATTATGAGGCAGCT[T]CACCCCTCCCAGCACTGGGG -3′ 
               
               
                   
               
               
                   614 
                 5′- CCAGCCCTGTAGTGGACATA[C]TTGCCTTTGCCTATTCAGCA -3′ 
               
               
                   
               
               
                   615 
                 5′- GAACTCGGTGGAGGAGAAGA[A]AAACTCCAAGATGCTCCAGA -3′ 
               
               
                   
               
               
                   616 
                 5′- TGTGGGCTGGACTTAGCAAC[T]CACTTCTAACTAACAGAATG -3′ 
               
               
                   
               
               
                   617 
                 5′- GGTGTCAATTCACTCCCAGC[A]GCACTGACTGAGTGCTGACC -3′ 
               
               
                   
               
               
                   618 
                 5′- ATGTTAGGCGGTCCCACCTG[A]GTTCTGGAGATCTTCACACA -3′ 
               
               
                   
               
               
                   619 
                 5′- GGTGGGCAGAGGCTGGATCC[C]ATGGTGAGGAGTTTCCATTT -3′ 
               
               
                   
               
               
                   620 
                 5′- TTGCCATGGGCCACCTCTAC[T]GAGTGCTCGATGAACAACAA -3′ 
               
               
                   
               
               
                   621 
                 5′- TTTGGCTGGGGCAAGCTTAC[A]TGGTTCGGCAGTAGTACCAG -3′ 
               
               
                   
               
               
                   622 
                 5′- GTGGCCCCAGGAATGGGGGC[A]TCTGGTGGTATCTGGGCTGG -3′ 
               
               
                   
               
               
                   623 
                 5′- ATGCATTGTGGTAGAYTCAT[T]CAATGGAGTATACACAGCAA -3′ 
               
               
                   
               
               
                   624 
                 5′- GTGGCAGCTGCGATYTYYCC[A]HTGCCACAAATGGTAGTTAC -3′ 
               
               
                   
               
               
                   625 
                 5′- TTGGGAGGAAGACCACAGAG[A]TGATGTGCCAGTCTCAGAAC -3′ 
               
               
                   
               
               
                   626 
                 5′- AAAATACAGGGTACAGGGAC[G]CTCAAAGAGTGATTTGCTTC -3′ 
               
               
                   
               
               
                   627 
                 5′- GTGAGATGGGGCACAGCAGC[A]GCCGGAAGGTTATTTGTGTG -3′ 
               
               
                   
               
               
                   628 
                 5′- GCAGGGCAGAGAAGGGGAAG[T]TGCTGGCTGCCCTCCTCACT -3′ 
               
               
                   
               
               
                   629 
                 5′- GCTCCTGGATTCACTCCTTT[G]ATCCTCACCTCAATCCTTTG -3′ 
               
               
                   
               
               
                   630 
                 5′- AGTTGGCTTGTATGGACCCC[A]CCGATGACGGACAGTTCCAA -3′ 
               
               
                   
               
               
                   631 
                 5′- AGTGGATTGAGGATGGACAT[A]TGTATCTGGAAGCACCAAAA -3′ 
               
               
                   
               
               
                   632 
                 5′- CTGGGTTCACTGGAAATCAG[C]ATTAAGAATGTACAAGGGAA -3′ 
               
               
                   
               
               
                   633 
                 5′- ATGTAAACTGCCTTTGAAAG[G]CTATAACACAGTTCAGTTGG -3′ 
               
               
                   
               
               
                   634 
                 5′- ACTTAATCTTGCTCAGTTCC[C]CAGTTTACACTTTTGAATGG -3′ 
               
               
                   
               
               
                   635 
                 5′- GCAGCATAGATGAATGTAAT[G]TTGAAACAGGAAGATGTGTT -3′ 
               
               
                   
               
               
                   636 
                 5′- CTTAGCCTGCAATTGCAATC[T]GTATGGGACCATGAAGCAGC -3′ 
               
               
                   
               
               
                   637 
                 5′- TAGCCGTTTACAGAATATCC[A]GAATACCATTGAAGAGACTG -3′ 
               
               
                   
               
               
                   638 
                 5′- GTTTCAGATTTTGATAGGCG[T]GTGAACGATAACAAGACGGC -3′ 
               
               
                   
               
               
                   639 
                 5′- ATGAGGGAGAAATGCCCTTT[C]TGGCAATTGTTGGAGCTGGA -3′ 
               
               
                   
               
               
                   640 
                 5′- AGGAACAGTGCTACTTACTG[A]TGGGTAGACTGGGAGAGGTG -3′ 
               
               
                   
               
               
                   641 
                 5′- TTGGCAATGGGTAAGTCTAT[T]GTACTGTGTAAACTTGGACT -3′ 
               
               
                   
               
               
                   642 
                 5′- GATATAGATCTCTTGGAAAT[A]TAATAATGGTATGCAGGAAG -3′ 
               
               
                   
               
               
                   643 
                 5′- GCAACCCGGGGAAATACAGC[A]AAATGCACAAGTACTGGCTG -3′ 
               
               
                   
               
               
                   644 
                 5′- CTGTACAAACTTTCTTCCAT[G]ATTTTGATTATATCCATTTT -3′ 
               
               
                   
               
               
                   645 
                 5′- CCCTCATTATCTGCCTAAAC[A]ATTTTTTCTCAACTCCTATA -3′ 
               
               
                   
               
               
                   646 
                 5′- CTAGCACTGTACACACCCCA[T]ACTGTGTATGCTATTTGTTG -3′ 
               
               
                   
               
               
                   647 
                 5′- CAAAAGTTATCTCTAACCAA[G]GTACTCAAACAGAGTCTTTA -3′ 
               
               
                   
               
               
                   648 
                 5′- CCTTGTAAATCTCCACCTGA[T]ATTTCTCATGGTGTTGTAGC -3′ 
               
               
                   
               
               
                   649 
                 5′- TCCCATAGGAATTATAAAAT[T]GAAAAGTATGACAAAAATTT -3′ 
               
               
                   
               
               
                   650 
                 5′- AGGCCCTTCAGCTTCACCAC[T]TGCTTCTCTTTAAACAAGTC -3′ 
               
               
                   
               
               
                   651 
                 5′- GATAGAATTTGGCCCAGAGA[A]GTTAACTAATATATCCATGA -3′ 
               
               
                   
               
               
                   652 
                 5′- CTGTTTCTCCTTAAAATGGA[A]AAATGGCCTCTACAGAGTAG -3′ 
               
               
                   
               
               
                   653 
                 5′- GCTTGGTGGGGCCACTGGGC[A]TCTGTTTCTCGGGTGTTTTG -3′ 
               
               
                   
               
               
                   654 
                 5′- CCATTCCCTCGGCGAAGAGC[A]GAGGTTGAAGAAATGCTACT -3′ 
               
               
                   
               
               
                   655 
                 5′- GCAAGGGCCAGAGCCTCTGT[A]TGCTGCATTCGGCAACCACA -3′ 
               
               
                   
               
               
                   656 
                 5′- GGTTCCTGAAGGAGGAGTGG[G]AGTTTGGTAAATGGATGGAG -3′ 
               
               
                   
               
               
                   657 
                 5′- TTACCTGCTAAGGCCTGCAA[C]CTTGAGGATGTCCAGGGCTG -3′ 
               
               
                   
               
               
                   658 
                 5′- CCAGAAGGTTTCTTTGCTCC[T]CTTCCCTACAAAGACAGAGC -3′ 
               
               
                   
               
               
                   659 
                 5′- AATTCACTCCTTTAAAATAC[G]CAATGCAGTGTTTTTAGAAA -3′ 
               
               
                   
               
               
                   660 
                 5′- CCACTCCCTCTCCTGCTCTT[A]TGTGTGTGATCCAAAGGGAA -3′ 
               
               
                   
               
               
                   661 
                 5′- CAGGGACAGCTGAAGCCAAG[T]TCTCCCAAAGCAGCCTTGGC -3′ 
               
               
                   
               
               
                   662 
                 5′- GTCAGGAGCCTGGCCAGGCC[A]CACCCCTTGCTGTCTCAGCA -3′ 
               
               
                   
               
               
                   663 
                 5′- GGAGATTCTGCCTCAGGGCC[A]TGAGAGTCCCATCTTCAAGC -3′ 
               
               
                   
               
               
                   664 
                 5′- GCTCAGCTACCGTTGGTGGC[G]TTTATTAAACTGTGCACCCA -3′ 
               
               
                   
               
               
                   665 
                 5′- AAGGTGGCTGACTCCAGCCC[C]TTTGCCCTTGAACTGCTGAT -3′ 
               
               
                   
               
               
                   666 
                 5′- TGAAGACCTGAAAAGCAAAT[G]CCAGGCAGCCCCACTCCCTC -3′ 
               
               
                   
               
               
                   667 
                 5′- TTCTTTGTAATTTGGAATCC[T]CCTAATTTCCAAATGGGTTC -3′ 
               
               
                   
               
               
                   668 
                 5′- GGGACCTGGCCCTGGCCATC[T]GGGACAGTGAGCGACAGGGC -3′ 
               
               
                   
               
               
                   669 
                 5′- AGGTGGGGACCCGGCTCCAA[G]GGCACCCGGGTCTTCTGCAG -3′ 
               
               
                   
               
               
                   670 
                 5′- ACAGGCCGCTCTCCCAGCAG[T]GTGTTGAGGTGCACAGCCAG -3′ 
               
               
                   
               
               
                   671 
                 5′- TGGCGCAAGAGAACCAGGGC[A]TCTTCTTCTCGGGGGACTCC -3′ 
               
               
                   
               
               
                   672 
                 5′- TGCTGTGCCCACATCCCCTG[G]AACAGGCAGCCCAGCCTGTG -3′ 
               
               
                   
               
               
                   673 
                 5′- TGGTGAGTTATGGACCCYCC[C]ACCTCCACTACTACACTGTA -3′ 
               
               
                   
               
               
                   674 
                 5′- TCAGGGCCTGGGGCAGGCGC[T]GCACAGCCCCCACCGCTGCT -3′ 
               
               
                   
               
               
                   675 
                 5′- GCATGGCATGCGGAAGATGG[C]GAAGAATGTTTTATGGCCTC -3′ 
               
               
                   
               
               
                   676 
                 5′- TCTCAGTAGCTGAGACCTGA[A]AAATTTGGAGAATCACTTTG -3′ 
               
               
                   
               
               
                   677 
                 5′- ACATGAGGCCACTGAGGCAG[G]CCTCTTTCCTTCCCCTTCTC -3′ 
               
               
                   
               
               
                   678 
                 5′- CCTATTCTTAATCCTATTTT[A]CAAATGAAGTGACTTGCCCA -3′ 
               
               
                   
               
               
                   679 
                 5′- GGAATGGGTCAAGAATGTTC[C]TTCCCTTCTGAATGTCCCTG -3′ 
               
               
                   
               
               
                   680 
                 5′- AAGCGGGGAGGAGCTAAATA[A]TATTTTTCTCTCCTTGTTCA -3′ 
               
               
                   
               
               
                   681 
                 5′- AACTTGGAACATCTCCGCAA[T]AAGACAGAGGATCTGGAAGC -3′ 
               
               
                   
               
               
                   682 
                 5′- ACATCGCAGAAGGTGGCTCG[G]AAATTCTGGTGGAAGAACGT -3′ 
               
               
                   
               
               
                   683 
                 5′- TTCCCGAGGCCCTGCTGCCA[C]GTTGTATGCCCCAGAAGGTA -3′ 
               
               
                   
               
               
                   684 
                 5′- TGAGAGTCAGGGTTTCGGAC[T]AGATTGGCAAGTCAGGCTCT -3′ 
               
               
                   
               
               
                   685 
                 5′- TCTCCAGGACCTAGTATGGT[A]CCTGACCGTGGCACTCATAG -3′ 
               
               
                   
               
               
                   686 
                 5′- CTACCTCAGAGTATGTGCCC[G]TTGGATGGTGGCTGTTATTC -3′ 
               
               
                   
               
               
                   687 
                 5′- CTAGTCTCTGAGCTGAGTGC[T]GACTTAGGGAGGCAATGTTA -3′ 
               
               
                   
               
               
                   688 
                 5′- ACAGTGTGGCGTAAGGCAGT[A]TGGCCCTTGTCCTCTTGCTT -3′ 
               
               
                   
               
               
                   689 
                 5′- TTAGGGCAGCTGTGCATTGA[T]TGGGTAGACGCCATTCTGGA -3′ 
               
               
                   
               
               
                   690 
                 5′- TGAGGCCCCCACCTGGCCCT[C]ATCTGCCCCTGAGATCTAGA -3′ 
               
               
                   
               
               
                   691 
                 5′- CGCATAATTTCCGTCACCTC[G]TTCGCCTGCTGCTGGCACCG -3′ 
               
               
                   
               
               
                   692 
                 5′- CCCCAACATGTGCACCCCTG[T]ATTTCCTGTCATGCCACAGA -3′ 
               
               
                   
               
               
                   693 
                 5′- CCAGATCTCCATCATTGGCG[G]TAGTCTCTGGTCACCTGACT -3′ 
               
               
                   
               
               
                   694 
                 5′- TTTGTTCTGACTTTACATCC[T]CTTCCCCAGGTCACTTTTCA -3′ 
               
               
                   
               
               
                   695 
                 5′- ATTCCTGTCCCTTGTGCCGC[C]ATGAGCTGCCCACTGATGAC -3′ 
               
               
                   
               
               
                   696 
                 5′- TTTGATACCAAGAACACATT[A]CTGCATGAATCCTCCAGCAA -3′ 
               
               
                   
               
               
                   697 
                 5′- TCTAAAATTAGGGGTTTGAT[G]TAGCTTATCTGGAAGGTGTT -3′ 
               
               
                   
               
               
                   698 
                 5′- GATGCGGTCTGGAAAGCACC[G]GGGTGGCCGTCGGCTGACGC -3′ 
               
               
                   
               
               
                   699 
                 5′- CTCCGTGGAACTTCTCCTGG[C]ACAAATTCTGTTCCTAGGGA -3′ 
               
               
                   
               
               
                   700 
                 5′- GAGGGGAGCCACAGGAATGG[T]CGTGGCCAGAAGCCCTTCTC -3′ 
               
               
                   
               
               
                   701 
                 5′- GGCACCTTTTCCCTGATAAG[C]CACAAATCATAACCAAACAA -3′ 
               
               
                   
               
               
                   702 
                 5′- TTGCACTCCAGTTTTTTTTT[T]TTTAAAAAAGCGGTTTCTAC -3′ 
               
               
                   
               
               
                   703 
                 5′- GAAAAGGCTGTCTGATTATC[A]TGTCATCCAAAAAAAACAGA -3′ 
               
               
                   
               
               
                   704 
                 5′- GAACTAAGAGGAATAAAGGT[G]TTGCTTTATACCTGTCCCTA -3′ 
               
               
                   
               
               
                   705 
                 5′- ACTAACATGTCCTGCCTATT[T]TCTGTCAGCTGCAAGGTACT -3′ 
               
               
                   
               
               
                   706 
                 5′- GCTGACCCAGGGTCCACATG[T]TCTTTTTCTAACTTGTTCAT -3′ 
               
               
                   
               
               
                   707 
                 5′- TGCTTCCCCATTTCTGTCCT[G]AAAGCCCTCTGGCAAGACTG -3′ 
               
               
                   
               
               
                   708 
                 5′- CAGTGATGAACTCCTGGGCT[G]AAGTGACCCACCCGCCTCTG -3′ 
               
               
                   
               
               
                   709 
                 5′- GCGACTTCGACTAAGCAACA[C]TGCATCTATTTTCATGCAAC -3′ 
               
               
                   
               
               
                   710 
                 5′- CCTCAAATGTTAGAGTCAGT[A]CACCAGCTCATAGTTTCCAT -3′ 
               
               
                   
               
               
                   711 
                 5′- CGTTTAATTCTTTCTCATCA[C]TTTCCTAGGGCATTTGCAAT -3′ 
               
               
                   
               
               
                   712 
                 5′- CATCAGAGTTTTATGATTAG[C]AGATATATCTTAACTGACAC -3′ 
               
               
                   
               
               
                   713 
                 5′- AGCAAAACCAAAGAAATCAGC[A]GAAGACCATAAAAACAGACG -3′ 
               
               
                   
               
               
                   714 
                 5′- CTATAAAATTAGTATGCTTA[C]AATTATTAAACATATACAGA -3′ 
               
               
                   
               
               
                   715 
                 5′- TAAACACTTTAATGCAGTGA[C]ACTCAGGTATAAAACTCAGA -3′ 
               
               
                   
               
               
                   716 
                 5′- ATAGAAGACAAAGTTTTCAT[T]CGTCTCATTCAAGTTCACTT -3′ 
               
               
                   
               
               
                   717 
                 5′- AGTGCAGGGCAGGACTGCTG[G]CTGACCCCGGGCCACCTGGA -3′ 
               
               
                   
               
               
                   718 
                 5′- AACCTCTTGGTACATGTTAG[A]GGAAATGAAGCTGGCAACAA -3′ 
               
               
                   
               
               
                   719 
                 5′- TCATCAGATCAAGGACATTA[C]GGAATTAAAGGGCTCTAAGA -3′ 
               
               
                   
               
               
                   720 
                 5′- CCACTGCTATTGGTTATTTA[C]CTAGCATCCATTTCCCTTTA -3′ 
               
               
                   
               
               
                   721 
                 5′- ATCTACCTCTCCTGCCTCAT[A]TATTATTACCCAGCCCCTTC -3′ 
               
               
                   
               
               
                   722 
                 5′- GTCAATTGCAAATGGAGGTG[A]GACCTGAGAAAACAAAGAAA -3′ 
               
               
                   
               
               
                   723 
                 5′- GAGTGTGTAACAACTCACCT[G]CCAAATCGACTAGCCCTTAG -3′ 
               
               
                   
               
               
                   724 
                 5′- CTTGTAAGCCATCTTAAGCC[G]TTATAGGCCTAAGATGTATA -3′ 
               
               
                   
               
               
                   725 
                 5′- CTTGAGACCTGTGTCTCCTC[A]TGTTCACACTGTTCCTGACT -3′ 
               
               
                   
               
               
                   726 
                 5′- GAGGCATGGGTTGAACTGCA[T]TCACATATGTACTTAAAAGA -3′ 
               
               
                   
               
               
                   727 
                 5′- TGTTTCTTGAAGTTTGACTA[C]TTAAAAACATAGGTGTAAAG -3′ 
               
               
                   
               
               
                   728 
                 5′- AGAGTCACGGCATGTGGGAA[T]GTTTCCATGGACACTGGATC -3′ 
               
               
                   
               
               
                   729 
                 5′- AATGAGATCTTATGTCAAGG[A]TTTAATCTTTGGTATTCCAA -3′ 
               
               
                   
               
               
                   730 
                 5′- TCTGGACCTCAGTTTCCTCA[A]TGAGCTGGTAAGAATGCACT -3′ 
               
               
                   
               
               
                   731 
                 5′- AGGTTGATAGCAATGTTTGG[G]AGATATGTCCTAGAAGTGTT -3′ 
               
               
                   
               
               
                   732 
                 5′- GCATGATAACCCGAGCCATC[A]CTAAATATTATAGCTTCCTT -3′ 
               
               
                   
               
               
                   733 
                 5′- CTCCAGTTTCTCCCTTTCTC[G]CCAACTAGGTCCATCCAAAC -3′ 
               
               
                   
               
               
                   734 
                 5′- AACTGTAAGGATCTCTTGCT[T]TATATACTATTGGGGGAACA -3′ 
               
               
                   
               
               
                   735 
                 5′- CCTTAGCTCTTCCTAAAACA[C]ACAATCATAAAGGAAACCGT -3′ 
               
               
                   
               
               
                   736 
                 5′- CTGACAGTAAAGGGAACTCA[G]TATGTCTGAGTCTTTGCTCA -3′ 
               
               
                   
               
               
                   737 
                 5′- AACATTTACAGAAGCGAGAA[A]AAGTTTTGTTTGCTTTTGTT -3′ 
               
               
                   
               
               
                   738 
                 5′- TAAGTTCAATAAATCCCAAA[C]TGCACACTCTGAATTAGGGG -3′ 
               
               
                   
               
               
                   739 
                 5′- AAGATAGCCATCTTTGGGCA[G]AGAGTCATGAAATGTACCCT -3′ 
               
               
                   
               
               
                   740 
                 5′- GCTGGGCCGACGGGGACGAG[A]CGGCGACTGGAGCAGCAGCG -3′ 
               
               
                   
               
               
                   741 
                 5′- CTCTGTCTTGGTCACTGTGC[G]AGGATTGAAGGGAACTATTG -3′ 
               
               
                   
               
               
                   742 
                 5′- ATCGTCTTTTACAATAAGAT[G]CATGCCCCTATGAGTATTTT -3′ 
               
               
                   
               
               
                   743 
                 5′- AAGGAGAAAAACAGTGAACC[A]TAGTTCTTACTGCTCACACT -3′ 
               
               
                   
               
               
                   744 
                 5′- GATTATTTGATTGCCATGAA[C]GAAGCTGAATTACATAATTC -3′ 
               
               
                   
               
               
                   745 
                 5′- AGGGACCTGTCTTCAGAATC[T]AAGAAGCATAATGTCCTTAA -3′ 
               
               
                   
               
               
                   746 
                 5′- TAGAGTCCCTACCATGCACC[C]TGGGCAAGAAGTCAGTTCTG -3′ 
               
               
                   
               
               
                   747 
                 5′- TCGGGTCTCTTACCATGCCC[G]CCCTCCCTTCCTCAGGGAAT -3′ 
               
               
                   
               
               
                   748 
                 5′- AGGACCTTCAGAGACCCCGC[G]TTCTCTGAAACCAGGATGGA -3′ 
               
               
                   
               
               
                   749 
                 5′- CAGGGGCTGCACTCACCATC[G]TCTGACACCTCCACTTCATC -3′ 
               
               
                   
               
               
                   750 
                 5′- GTACACAAGGGTAGGGCAGA[G]GATGGACAGCAGGGCAGAAT -3′ 
               
               
                   
               
               
                   751 
                 5′- AGTTTCTGCAGCACTTTATC[T]TTCCATCTGGCCATGAGGAA -3′ 
               
               
                   
               
               
                   752 
                 5′- CAGGCATTGAAGGTCAGCTT[G]TTCTCCTCCTGGGTGAGTTT -3′ 
               
               
                   
               
               
                   753 
                 5′- GGGCACGACCTACCATCCAC[G]GTGACTTGGCAGGAGCACTC -3′ 
               
               
                   
               
               
                   754 
                 5′- TTACTTCTATCCTTGCTTCT[T]GAACTGGTCATTCCCTGACT -3′ 
               
               
                   
               
               
                   755 
                 5′- AGAACAAGCTGTTAGCAGGA[C]GCCTCTGCTGCTGCGGGGCC -3′ 
               
               
                   
               
               
                   756 
                 5′- TCGGCTGGGATCTCCTTCAG[T]TCGTCTTCCGATAGGGTCTT -3′ 
               
               
                   
               
               
                   757 
                 5′- AGGCCTCAGGGACCCATAGC[A]GTCACTACCACCACCATCAG -3′ 
               
               
                   
               
               
                   758 
                 5′- TTGTCCAGAAATCACTGTGA[C]TGGATACACAAATGCAGCAC -3′ 
               
               
                   
               
               
                   759 
                 5′- CTTGGCTGCTGAATGGTGAG[A]TCCCCCTGCCCCAGCTCTCT -3′ 
               
               
                   
               
               
                   760 
                 5′- GAAGTCTTCTGAAGGACCGG[G]GTCTGCGGGGCCGTTCTGGG -3′ 
               
               
                   
               
               
                   761 
                 5′- TGGTGGCTTTTGTTTCTCTC[G]CAAATGACCTGTGTGGTGGT -3′ 
               
               
                   
               
               
                   762 
                 5′- AGGACGGGTCTCCACTGCTG[G]AGCTGAAAATCTATCCCTGT -3′ 
               
               
                   
               
               
                   763 
                 5′- TTTGTGACCTTGTATGGATG[ACTTA]ACTTCTCTGAATCTTATTTC -3′ 
               
               
                   
               
               
                   764 
                 5′- AAAACTCAATAAGATGCCTA[T]ATTTTATGCATCTCCATTAA -3′ 
               
               
                   
               
               
                   765 
                 5′- TTCACCATCCCTCTACTTTC[G]GCTTGCCAAAACTTACAGGA -3′ 
               
               
                   
               
               
                   766 
                 5′- TGGCCAGTGCTCAGCAGATG[G]AAGTTCCAAATCGAGTCACT -3′ 
               
               
                   
               
               
                   767 
                 5′- GCATGGAGTCAACTCTTGAG[T]GATCCACACTGAGGGAGGTT -3′ 
               
               
                   
               
               
                   768 
                 5′- TGACTCCTGGTCCAGGGCCT[A]CTGGGGACTAGATAAGATGT -3′ 
               
               
                   
               
               
                   769 
                 5′- CAAGCTAGAGACTTGGTATA[C]AGCAGCAGTTACATGAGTGG -3′ 
               
               
                   
               
               
                   770 
                 5′- CAGACTGTGGACATCCGAAT[T]GGCAATGACATGAATTTAAG -3′ 
               
               
                   
               
               
                   771 
                 5′- AGGCACCAGGTCCCATGGCC[G]GTTTCCCCTGAGAAAACATT -3′ 
               
               
                   
               
               
                   772 
                 5′- ATGGAGAGCTGCCAAGCCAA[C]CCTGCCAGGGTCATCAGCTC -3′ 
               
               
                   
               
               
                   773 
                 5′- ATAGCTGTCCTTACTCCTTT[C]CTAGACAGACAGTGTCTTGG -3′ 
               
               
                   
               
               
                   774 
                 5′- GCTTTTTATACCGCTTAACG[A]AAATAATTTAAAAGGCTGTC -3′ 
               
               
                   
               
               
                   775 
                 5′- AGCTGCAATGCCTATGAGCA[G]GACCTGGGTTTGTACATCTT -3′ 
               
               
                   
               
               
                   776 
                 5′- CTAGGATAGCAGAGATATTA[C]TTCAGGATCAGATCTTGACT -3′ 
               
               
                   
               
               
                   777 
                 5′- TCTGGGGAGTCTTTAGCCCC[C]AGCAGAGGCCATTTCTAGCA -3′ 
               
               
                   
               
               
                   778 
                 5′- GAATAAAACTTACGGAGAGC[C]TCTAACTTCATTCAATTTGT -3′ 
               
               
                   
               
               
                   779 
                 5′- ATAATATATTTTAAGCAGGG[T]AGGGTATCCCAAGATCTCAA -3′ 
               
               
                   
               
               
                   780 
                 5′- GTATGGTAAAGAATCCCACT[C]CTGCATCAATCAGTGGGCAA -3′ 
               
               
                   
               
               
                   781 
                 5′- TTTTCCTTACACCAAGCTTA[C]GTGGGTGGCTGTAGCCACAA -3′ 
               
               
                   
               
               
                   782 
                 5′- GCACCATGGGGGAAATTATC[G]GTATTATTTTTTTGAAATCA -3′ 
               
               
                   
               
               
                   783 
                 5′- TATAGYCAAAGAGTTGTGCA[C]TGATCACCTCAATGAATTTA -3′ 
               
               
                   
               
               
                   784 
                 5′- GTTCTGGGCAACTGCTTTAG[T]CTGAATGCAAAAAACTGGAA -3′ 
               
               
                   
               
               
                   785 
                 5′- AAACAAAAGCCCCACAGCAA[A]AAACAGGAAGGAAGGGGAAC -3′ 
               
               
                   
               
               
                   786 
                 5′- ATAGTGAGGGATGACTGTAT[C]TTCCACTTAAAAATCCCAAG -3′ 
               
               
                   
               
               
                   787 
                 5′- GGAAAATAAAACTGTACCTC[G]TCTCCAGTCTCCCCATATTT -3′ 
               
               
                   
               
               
                   788 
                 5′- TAATGGCTTTCAAAGTGCCT[G]AATTCCATTCTACACTAAAA -3′ 
               
               
                   
               
               
                   789 
                 5′- ACCTCAAAAGAAAAAATAAC[A]TAAACAATATTCAACTCAAG -3′ 
               
               
                   
               
               
                   790 
                 5′- GCTTGGTTCAGGCCCTGGTT[A]CATACCTGGATTTCAAATCT -3′ 
               
               
                   
               
               
                   791 
                 5′- ACCCACAGCTTTCAGCAGTG[A]AGAATATGAATGGAAACTGG -3′ 
               
               
                   
               
               
                   792 
                 5′- GAGTGAGGTAGAGAACAGGT[A]TAATTCACCATAAGTCCTGA -3′ 
               
               
                   
               
               
                   793 
                 5′- ACCTGGTTCTTTGAAAGAAC[A]AATAAAATTCACAAACTGCT -3′ 
               
               
                   
               
               
                   794 
                 5′- TTTTTCTCTTCAGCTGGCCC[G]AATTGGTTTCTGTTAATTTT -3′ 
               
               
                   
               
               
                   795 
                 5′- GAAGAGACTAAGAGAATCAC[G]GAAGAGAGAAGGAGGTCAAG -3′ 
               
               
                   
               
               
                   796 
                 5′- TCTTGAAGGGTTTTAGTTCC[G]TAAGTTCCAGGGAGGGGTCT -3′ 
               
               
                   
               
               
                   797 
                 5′- AAACGTTTAATTCTTCTGTG[A]GTTCTGTTCTAATTTCTGAG -3′ 
               
               
                   
               
               
                   798 
                 5′- AGGCCTAGAATTCTCTGAAA[C]GTCATTTTTCAGTTTCTACA -3′ 
               
               
                   
               
               
                   799 
                 5′- GTAGCCTTGCGCCTCACTCT[C]GTGATGGAGCCGCCTGCTAC -3′ 
               
               
                   
               
               
                   800 
                 5′- ATTGTCATTTTCCTTGTGTT[T]TATTGGTTCAGGCTATCCAA -3′ 
               
               
                   
               
               
                   801 
                 5′- CAAGGCATCTTGGCTCCTAC[A]TAGGGCCTTTTGGCTCCTCT -3′ 
               
               
                   
               
               
                   802 
                 5′- AGATCTCCAAGGTTTTCACC[A]AGAAACACTTGACCCGACTT -3′ 
               
               
                   
               
               
                   803 
                 5′- GCTCAATGCAGAGGGGTCAT[A]AGAGCAGGCTGGGAGCCAGA -3′ 
               
               
                   
               
               
                   804 
                 5′- GTTCCTCCTCAGAAACTGCC[G]TGTATGAGTTTGTATCCTTA -3′ 
               
               
                   
               
               
                   805 
                 5′- CATAGGCGAGGCCCAGCCCA[T]GTGTCCAGAGACATCTGTGA -3′ 
               
               
                   
               
               
                   806 
                 5′- GCTCTTCAAGGTCTGGTGCT[C]TCTTCCACAGTACTGTAGCC -3′ 
               
               
                   
               
               
                   807 
                 5′- AAATGGGTGCTCAGACCCCT[G]TCCTACTTACCTCAAAAGGT -3′ 
               
               
                   
               
               
                   808 
                 5′- TGTCAGCAGCCTGGTATTGG[A]AAGAGTTAAAGGAAAATCTC -3′ 
               
               
                   
               
               
                   809 
                 5′- CAGTTCAGGGGAGGAGCCTC[G]GGACGTCAGTGGCAAAATCA -3′ 
               
               
                   
               
               
                   810 
                 5′- GCATAGGCTTAACTCGCTGA[A]GAGTTAATTGTTTTATTTTT -3′ 
               
               
                   
               
               
                   811 
                 5′- AGGGGAAACGTCTCCCAGAT[T]GCTCCCTTGGCTTTGAGGCC -3′ 
               
               
                   
               
               
                   812 
                 5′- AGCCAAAGCCAGAGTGGCCA[T]GGCCCAGGGAGGGTGAGCTG -3′ 
               
               
                   
               
               
                   813 
                 5′- TTTCAGAGAGGGAAGCCAGA[A]GAGAAGAGGGTGCAGGCTGA -3′ 
               
               
                   
               
               
                   814 
                 5′- CAAGTCCTCCGGTTCTTCCT[T]GGGATTGGCGGGTCCACTTG -3′ 
               
               
                   
               
               
                   815 
                 5′- AGGCTGCCTCCGCACCTGAC[T]GCTGCCCAGGTGGGGTTTCC -3′ 
               
               
                   
               
               
                   816 
                 5′- TGGCTAGGACAGGGTCTCGG[A]CTAGGGAAGTGGTTTCTCTG -3′ 
               
               
                   
               
               
                   817 
                 5′- TTACGGGAAGCCCTTCTGGC[A]CTCACTCAGGGCAGCAGCTT -3′ 
               
               
                   
               
               
                   818 
                 5′- GCCTGGGCAGGAAGAGGGAC[G]AGAGGGTCTCCCACATGGGA -3′ 
               
               
                   
               
               
                   819 
                 5′- ATCGTGTTCCCCAGGAAGTT[A]TTCTTGATTTAGTTTAAACT -3′ 
               
               
                   
               
               
                   820 
                 5′- GAACCACCTTCTCTTGCCAG[G]CTGTACTCCTCATTTAGTTT -3′ 
               
               
                   
               
               
                   821 
                 5′- AAGGTGGGAGCCAGAGTGGG[T]TGCTGTAGGGGTGAGGGAGG -3′ 
               
               
                   
               
               
                   822 
                 5′- GCCATCCAGCGCGGCTGCTC[G]GGCGCCACCTCCATGGCCGG -3′ 
               
               
                   
               
               
                   823 
                 5′- TCCCTGGGCCCGTCGCCCTC[T]GGGCTCCCGCCGGAACTCCT -3′ 
               
               
                   
               
               
                   824 
                 5′- ACACAGACATTGTCGAGCGC[C]GGTCCCTCTTTATTGGCCAG -3′ 
               
               
                   
               
               
                   825 
                 5′- GCCTGGTGAGAGCAGATTTA[T]TCCAATTTATGGGCTGGAAC -3′ 
               
               
                   
               
               
                   826 
                 5′- CACACCGACACACATGGCCA[T]ACAATCAGATGCAACTCGGC -3′ 
               
               
                   
               
               
                   827 
                 5′- CTTGTTCACAGAAGTGGGAG[T]CAGGAGGGGGGGAGAAAGTG -3′ 
               
               
                   
               
               
                   828 
                 5′- AGGACCAGGCGGCTAAGCAG[A]GAGAAGAGCCAGAGGGGCGT -3′ 
               
               
                   
               
               
                   829 
                 5′- CGGGCCATGGACACCGACAC[A]CTGACACAGGTCAAGGAGAA -3′ 
               
               
                   
               
               
                   830 
                 5′- CTGCGGTTCAGCTCCTTGGT[C]AGATCTGTCATGTCTGTCTG -3′ 
               
               
                   
               
               
                   831 
                 5′- GCACGTCGGCTCTTGGTACA[A]AAGACGAACAGGGCTGCGGG -3′ 
               
               
                   
               
               
                   832 
                 5′- TCCCCCGGGGCCCTGAGCAA[T]GCATCAGCGCCAGTGGACTT -3′ 
               
               
                   
               
               
                   833 
                 5′- TTCACCAGGACCTGGAGCTC[A]GAGCCTACATGGAGGTCATT -3′ 
               
               
                   
               
               
                   834 
                 5′- ACGGTCACCACACCTGAGAG[C]GGTCCTGGGGCTGGCCCTGT -3′ 
               
               
                   
               
               
                   835 
                 5′- GCGGCAGCCATCACTCCACA[C]GCACAGGTGACCCAGGTCTT -3′ 
               
               
                   
               
               
                   836 
                 5′- AGGATGTTCTGGGAGCCACC[G]GTAGGCACGGGTGCCAGGGG -3′ 
               
               
                   
               
               
                   837 
                 5′- TGGAATGAGCAACACAGGAA[G]GCTCCAGTTGTCCAGACCAT -3′ 
               
               
                   
               
               
                   838 
                 5′- CGAGACTGGTTGGAAACACA[A]GAGTGCTGCTGGCTGCACCA -3′ 
               
               
                   
               
               
                   839 
                 5′- CCCCCATCCATTCCAGACCA[T]GTGACTGTTGAGATGTCTGT -3′ 
               
               
                   
               
               
                   840 
                 5′- TCGATGTGCGCCAGGAGTAC[T]CAGTGAGTCCTGGGGGAGGC -3′ 
               
               
                   
               
               
                   841 
                 5′- AGTTTGACCCAGCAGACTCC[A]GTTACCTTTACCTGATGACG -3′ 
               
               
                   
               
               
                   842 
                 5′- CCTACCTTGAGAAGCCTCCC[A]TTGACCGTGCCCAGGAAGAC -3′ 
               
               
                   
               
               
                   843 
                 5′- AGGCCTCCAGGAAGTGACCC[T]GAGACAATAACTGTGCAACT -3′ 
               
               
                   
               
               
                   844 
                 5′- GTAACTAAGCACACCCCTTA[A]AGAATTTTGGGAAGTCGCCC -3′ 
               
               
                   
               
               
                   845 
                 5′- TAAGCCAGAGGATGCTGTAG[C]GAGTACTTGTATGCAATAAC -3′ 
               
               
                   
               
               
                   846 
                 5′- CTTGTTGTCATGGTGCGTTG[A]AAGAGTAGCCAGTTGTCTTT -3′ 
               
               
                   
               
               
                   847 
                 5′- ATTAGTATGCAGGTCTTATC[C]ACCATTGGAATTAAGCTGTT -3′ 
               
               
                   
               
               
                   848 
                 5′- ACGTTTTTATCACACATTAA[A]CACTTGCATTAATTTTGGAG -3′ 
               
               
                   
               
               
                   849 
                 5′- GATGAGTTAAATGGGCTAGT[A]TCTAAATTTTAAATTTTTAC -3′ 
               
               
                   
               
               
                   850 
                 5′- GTACATCCCATATTCCCTTT[C]CAAAATCTAGTTTCCTATGT -3′ 
               
               
                   
               
               
                   851 
                 5′- GCTTACCAGAAAACACCCTC[T]TTGTTGTTTTTATTTCTCAG -3′ 
               
               
                   
               
               
                   852 
                 5′- GGACAAGGAGGAGAAGCCCC[G]GGAGGTCACGGGAGTTCACT -3′ 
               
               
                   
               
               
                   853 
                 5′- GAGCAGCCATTTCGAAAGGC[G]GCAGAAGAGGAAATTAACTC -3′ 
               
               
                   
               
               
                   854 
                 5′- GCGAGGGGAAGTCATTTTTT[G]AATAACTAGGCTCTATTTGC -3′ 
               
               
                   
               
               
                   855 
                 5′- CAAGGAAAGACCTGGTGTCC[C]TGTGCTAATTTTAACTCTCT -3′ 
               
               
                   
               
               
                   856 
                 5′- TACAGATGCTCATAGGCATC[T]GAAAAAAAAATACTTTGTTA -3′ 
               
               
                   
               
               
                   857 
                 5′- AACTCCTTTGACAGTATGGA[T]GGCACCTAACGCATCCTTGT -3′ 
               
               
                   
               
               
                   858 
                 5′- GAGGTGTTTTCTTGGCTCTT[C]ACKAACGTTTTTAATAAAGC -3′ 
               
               
                   
               
               
                   859 
                 5′- GCGCCCCCTGGAGTTCTGCT[G]GAATTTAGATTTAAATAGAT -3′ 
               
               
                   
               
               
                   860 
                 5′- ACATATTTAGAATGGATGCC[A]GAACAGGAGAAATGGGTGGG -3′ 
               
               
                   
               
               
                   861 
                 5′- ATTCATATGCCACCAGCCAT[T]GGCAGAAATGTAACAGGAAA -3′ 
               
               
                   
               
               
                   862 
                 5′- ATGGCTCTGTAAATGGGATG[T]CTCATGTTCAGGTTTCTGGA -3′ 
               
               
                   
               
               
                   863 
                 5′- ATCTCCAGGTGAACATGGAA[T]GCAGTGAAAACCTGGGGTAT -3′ 
               
               
                   
               
               
                   864 
                 5′- TGATAAGTAGTTAATGATCC[A]GAAATAAACTGTTAGGTGCT -3′ 
               
               
                   
               
               
                   865 
                 5′- AAGTAAAATAGTAGATATTG[G]ATTGCTTCTACATTTACTAC -3′ 
               
               
                   
               
               
                   866 
                 5′- AGAGCCCCTACCCAATTGCT[T]TACTATTTATAGTTCCTCAG -3′ 
               
               
                   
               
               
                   867 
                 5′- ATCTGGGGACCTGCTCCTGG[C]AGAGCAATAGGAWCTGTGTG -3′ 
               
               
                   
               
               
                   868 
                 5′- GAGTCCCAAAATTCAACCCT[T]CCGATAGGGCTGGGCCTGAC -3′ 
               
               
                   
               
               
                   869 
                 5′- CCCTAGCCTGCTTTTGTCCT[A]TTATTTTTTATTTCCACATA -3′ 
               
               
                   
               
               
                   870 
                 5′- AGAGGGAACCCAAATATTAG[A]GTGGGAAGCAAGTCATAAAC -3′ 
               
               
                   
               
               
                   871 
                 5′- TAGGGTTACCAATCCACTAG[G]ATGCAAAACTGTACTTATTA -3′ 
               
               
                   
               
               
                   872 
                 5′- AGGCTTCTTTTTCCATTACA[T]TGTAAGACTTTGGAGGGCAG -3′ 
               
               
                   
               
               
                   873 
                 5′- AGCRGTCAGGTGCGGAGGCA[A]CCTCTCAGCGGTGGGGAACA -3′ 
               
               
                   
               
               
                   874 
                 5′- CAGGACAAACAGTGGATTCA[T]TCAGAACACAATATGCTGGT -3′ 
               
               
                   
               
               
                   875 
                 5′- AAGCCACTACAGACACCGCA[T]GCACCGAAATTCTCCCTTGT -3′ 
               
               
                   
               
               
                   876 
                 5′- ATCACTGTCCCTCAGTTCAC[T]GGTCTTGTCTGCTTCGTCGY -3′ 
               
               
                   
               
               
                   877 
                 5′- AATTCTCAGTCTTAAAAACA[G]GGCATAAAGAAAGCTAAAAT -3′ 
               
               
                   
               
               
                   878 
                 5′- AGAAGATAAGTGTTTAGGGT[A]TTGGATATCCCAGTTACCCT -3′ 
               
               
                   
               
               
                   879 
                 5′- CCTTTTTTTGGATGATCCTA[G]AATTAATACAAGTGTATTCT -3′ 
               
               
                   
               
               
                   880 
                 5′- GCCCTTAGTCACCAACTCCT[A]CTCATCCCACCATGCTGTTG -3′ 
               
               
                   
               
               
                   881 
                 5′- GTAAATTAAAATTTGTTTGG[G]TGATTTGTGCTGTATTTCTA -3′ 
               
               
                   
               
               
                   882 
                 5′- AGCAACACTTCCTCCTTGCA[T]ATTACAAGCATAGCTAATGC -3′ 
               
               
                   
               
               
                   883 
                 5′- CCCTCATTTTCTGTTAGGGA[G]GTATGTGTTTACCAAGCTGT -3′ 
               
               
                   
               
               
                   884 
                 5′- ATGAGGGCTTTACTTTTGCA[A]GAAATACTACAGATGGTGAA -3′ 
               
               
                   
               
               
                   885 
                 5′- TCCCTTCTCAGTAACTAACA[A]TAATCATCTCTCTGGAGGAC -3′ 
               
               
                   
               
               
                   886 
                 5′- CATTCCCTCACACAGTACAG[A]TTAATAAATGTGCATTTTGA -3′ 
               
               
                   
               
               
                   887 
                 5′- CCTGTGTGATGAGGGGCAAA[A]GAAGCTCTTGAGAACCTGCT -3′ 
               
               
                   
               
               
                   888 
                 5′- GTAACGAAGAAAGACCAGAG[C]GTCATCCCTGTGATACAGCA -3′ 
               
               
                   
               
               
                   889 
                 5′- TATGTATCTTGCTTTTGTTT[C]AAACAGTCATCCACATTAGT -3′ 
               
               
                   
               
               
                   890 
                 5′- GATAGGTTGCAAAATTTTGG[T]GTGTTCTTGCATTGCATACA -3′ 
               
               
                   
               
               
                   891 
                 5′- ATTGACGGTGTTATAATTAC[T]ATGGTTTTGAAATTACATAG -3′ 
               
               
                   
               
               
                   892 
                 5′- TGAGGACCCAGATGTCAACA[T]CACCAATCTGGAATTTGAAA -3′ 
               
               
                   
               
               
                   893 
                 5′- CTCCTTTTGACCTGAGTGTC[G]TCTATCGGGAAGGAGCCAAT -3′ 
               
               
                   
               
               
                   894 
                 5′- TATGTAAAAGTTTTAATGCA[T]GATGTAGCTTACCGCCAGGA -3′ 
               
               
                   
               
               
                   895 
                 5′- GATGGATCCTATCTTACTAA[T]CATCAGCATTTTGAGTTTTT -3′ 
               
               
                   
               
               
                   896 
                 5′- AATTAGCTGCCAGAGTTGCT[A]TCAGTAAAGAGAAGAAATAA -3′ 
               
               
                   
               
               
                   897 
                 5′- CTGAAATCAGAGAACATTGA[T]AGATGAAGTGAATGGCAGAG -3′ 
               
               
                   
               
               
                   898 
                 5′- GCCCATCTGAGGATGTAGTC[G]TCACTCCAKAAAGCTTTGGA -3′ 
               
               
                   
               
               
                   899 
                 5′- GTGCAGAYCAGATAATTATA[G]AGAGATGGAATGGGACAACC -3′ 
               
               
                   
               
               
                   900 
                 5′- AATCTGCCTCTGGGGCGGGA[C]CTGTCAGGCTTCAGGAAGGG -3′ 
               
               
                   
               
               
                   901 
                 5′- TCCAGGGAGGAGCTTCGTGC[A]ACCTTCCCGGACCACTCAGG -3′ 
               
               
                   
               
               
                   902 
                 5′- CATCACCTCCAGGTAGCTCC[C]AAAATGTCCCTAGAAAGTGG -3′ 
               
               
                   
               
               
                   903 
                 5′- GGAGCACAGAGTAGCAGTGA[C]GCTGTCCAAGGCAGGGGGGA -3′ 
               
               
                   
               
               
                   904 
                 5′- CATTCAGGCCAGTGGCTGCA[A]GGGAGCAGAAAGATCAGGCT -3′ 
               
               
                   
               
               
                   905 
                 5′- TACAGAGGAAGAAATCCAGG[A]CAGAGGTGGAGGCAGTGAAG -3′ 
               
               
                   
               
               
                   906 
                 5′- CTACCTCATTCATTGACCCC[G]CTATCTGACCTGTACATGTT -3′ 
               
               
                   
               
               
                   907 
                 5′- TTGAGGACAAACAGAACATC[A]GTGAGTAAGTGGAATATTAG -3′ 
               
               
                   
               
               
                   908 
                 5′- TTCTTGTGTTCTTCCCTTTC[T]ATTTCAACTCTTCATCTCAG -3′ 
               
               
                   
               
               
                   909 
                 5′- GGTTTGTGTACCAGGATTGG[A]GACCCCTGATGTATAGTGTA -3′ 
               
               
                   
               
               
                   910 
                 5′- GAAGAGGATAGGTTTTTCTA[T]CTTAAACAAAATCTTCCTTA -3′ 
               
               
                   
               
               
                   911 
                 5′- GTTAGGCATCAGGCAACTAC[A]AAGGAGTATACGAGCATGCA -3′ 
               
               
                   
               
               
                   912 
                 5′- CACAGGGTAAATTTAGCCAC[G]GCAGCAGGAGCATGATATAA -3′ 
               
               
                   
               
               
                   913 
                 5′- GGCATGTGAAATAAGTTGGT[T]TAATTAGAGTGAAGCCCAGG -3′ 
               
               
                   
               
               
                   914 
                 5′- TGGATTGTGTGTGTGGTAAT[G]GGATTATTGTTATATTTAAA -3′ 
               
               
                   
               
               
                   915 
                 5′- CACGAGCATCTTGCTGTCTT[T]AATTAAGAAGTTAACTGGAC -3′ 
               
               
                   
               
               
                   916 
                 5′- TTGAAAGCTGAGTCATTTTC[G]TAATGGGTCAGAAAGACATT -3′ 
               
               
                   
               
               
                   917 
                 5′- TACATGACGCATGTATTTGT[C]AAAACCCACAGATCTATTAA -3′ 
               
               
                   
               
               
                   918 
                 5′- CTGAGAGTGCAGTGAACCTT[C]GTGTCTGTGATGGAAGAGGT -3′ 
               
               
                   
               
               
                   919 
                 5′- GCTTAGATGTGAGAGTTGAT[T]CCATAATAATAAAAGTTATT -3′ 
               
               
                   
               
               
                   920 
                 5′- TTGAACTCTATGTACCAAGT[C]TGAACACATTCCAAATATCC -3′ 
               
               
                   
               
               
                   921 
                 5′- GGTATTTTGCTACAGCAGCC[T]GAGCAAACTAATATATCATC -3′ 
               
               
                   
               
               
                   922 
                 5′- AAAGGCGGTCACCTGCAGGA[G]TAGCCATCTTTGGTCCTTTC -3′ 
               
               
                   
               
               
                   923 
                 5′- CCCCCAGGGGTGGTAACAAC[G]GCACGCAAGCACAGCCATTG -3′ 
               
               
                   
               
               
                   924 
                 5′- CCACACCTGGTGGACAGGAC[A]ACCGTGGTGGCCAGGAAGCT -3′ 
               
               
                   
               
               
                   925 
                 5′- GGTTAAAAAGTTCTCTACCA[G]GGAAGTTGGATAAAAGTAAC -3′ 
               
               
                   
               
               
                   926 
                 5′- AAATCAGAATCGAATTATTG[A]TTTGGGGCTAATTGTATCTG -3′ 
               
               
                   
               
               
                   927 
                 5′- CCTGTCAGTGAAAACAACTA[T]CAAAGCTGGATTTTAAATAT -3′ 
               
               
                   
               
               
                   928 
                 5′- CCATTAGCAGTAGGTCTGAA[A]TAACTTTAATATGCAAGTTA -3′ 
               
               
                   
               
               
                   929 
                 5′- AGAGCCAGCTGGGAGAAACA[C]GCAACATAGTTCTTTGCAAT -3′ 
               
               
                   
               
               
                   930 
                 5′- AGCAGCTGGACCATGATCTC[T]TGGATATGGTGGTAGGTGAA -3′ 
               
               
                   
               
               
                   931 
                 5′- AGACGATGTACTGATGTAAG[C]TTTTGTAAATTTCTAAACTG -3′ 
               
               
                   
               
               
                   932 
                 5′- ACTCTGTCTTTCCAATTCCT[G]AACAGCATGCTTGGATGGGA -3′ 
               
               
                   
               
               
                   933 
                 5′- TCAGAAAGAATGGGGTAAGG[C]GAATTGAGTTTTAGAACATA -3′ 
               
               
                   
               
               
                   934 
                 5′- ACAGTGAAGAAAGAGGAACA[A]AGAGAAGGGCAGGCAGGAGG -3′ 
               
               
                   
               
               
                   935 
                 5′- TTGAAGGTGGATGAGGGAAC[A]GTCAGGTTGAGGAGCATTTT -3′ 
               
               
                   
               
               
                   936 
                 5′- ACACAATACTGGGTTTCTCT[A]CTTCTCTCTCACCATCACAC -3′ 
               
               
                   
               
               
                   937 
                 5′- CCACGCACCAGCAGGTTCAC[A]GTGCAGCTCATGCGGTTGTC -3′ 
               
               
                   
               
               
                   938 
                 5′- GATAGTCTAAATGAATGTCC[G]CCACCCCCGCCTGTAGTTGT -3′ 
               
               
                   
               
               
                   939 
                 5′- GCTGGCTGGGGCAAAGGTCT[T]TGATGCACTGTGCAGAAGTA -3′ 
               
               
                   
               
               
                   940 
                 5′- CTGCTCGGGCCAGAAAATCC[A]GAAACGGGCCCTTACCGATG -3′ 
               
               
                   
               
               
                   941 
                 5′- GTTCTGAAATGAAGACACAT[G]TGGCAGGCAGGTTACAACCC -3′ 
               
               
                   
               
               
                   942 
                 5′- CTCACTCACTCCTTGAGGAC[G]CTCTCATGACAACTGTAAAG -3′ 
               
               
                   
               
               
                   943 
                 5′- TTCAAAAACTATTTTGGTAC[A]TTTCAAATACAGTGTTTAAA -3′ 
               
               
                   
               
               
                   944 
                 5′- TGTTGCTAAGATCAATAGCT[A]CATTTGAATCTATGTCTCCC -3′ 
               
               
                   
               
               
                   945 
                 5′- CAGTTTATTATGGGTTATCT[G]ATTGGAATAAAGAGGTATCA -3′ 
               
               
                   
               
               
                   946 
                 5′- AATCATTATGTCACAAAAAA[A]TATATAAAGATAAATTTTTC -3′ 
               
               
                   
               
               
                   947 
                 5′- AGAGCCAAGACTTGTCCCCT[G]TTTCTGCAGCAGATTGGTCC -3′ 
               
               
                   
               
               
                   948 
                 5′- GTTTCTCAAAAGTTCTAAAC[G]TTACAGAGGATAATTTTAAG -3′ 
               
               
                   
               
               
                   949 
                 5′- CCTTGTCTGGAGGAGTTGGG[T]TTCCTCAATAATTGGCTGTG -3′ 
               
               
                   
               
               
                   950 
                 5′- GGATCCAAAGGGTGTCAAGG[T]GATCATTATCTTGGGATGGA -3′ 
               
               
                   
               
               
                   951 
                 5′- AATGAAACTAAATGATGATC[T]TTCAACTCTCCCTTCTCACT -3′ 
               
               
                   
               
               
                   952 
                 5′- AGTTGCTCCCCTCTCTGATC[T]ACATTCGTAAAATGACATAA -3′ 
               
               
                   
               
               
                   953 
                 5′- CAGGTGTCCCTACCTTAAGG[A]CCTCCTCCTTGGGACTTCAC -3′ 
               
               
                   
               
               
                   954 
                 5′- CACACAACTRGCTAAGGAGC[C]CCAGGGCCACAGCTGCTGTT -3′ 
               
               
                   
               
               
                   955 
                 5′- ATAAGCAGGAAAATGAATGC[A]TTAGGAGAGGTTTTATATCT -3′ 
               
               
                   
               
               
                   956 
                 5′- TTATGCATACAACACTCAAC[C]GATCCAGTTACTCTTACTCT -3′ 
               
               
                   
               
               
                   957 
                 5′- CACCCCAGTCACCGTGGCTT[A]CACCTGCACAACAGATTCCT -3′ 
               
               
                   
               
               
                   958 
                 5′- AATTTCCCTGCATTTTGTGA[T]GACTTGTTTTTATTGGTAAC -3′ 
               
               
                   
               
               
                   959 
                 5′- TGCGCATTTTCCGCACTCCG[G]TACACTTTACACTGAACACC -3′ 
               
               
                   
               
               
                   960 
                 5′- GACCCAGAGCAGGAAGCATA[A]TCAAGCCCTCCACTAGATTA -3′ 
               
               
                   
               
               
                   961 
                 5′- CACTTGGAAATCCTAACTCC[G]CAGAACAAAATTTTACAAGC -3′ 
               
               
                   
               
               
                   962 
                 5′- ACACACTGACATTCGAGGCC[C]AAGGAATACTCCTGCCTCTA -3′ 
               
               
                   
               
               
                   963 
                 5′- TTCATTTACAAGCCTGATCA[G]CCTTACATGAACTAATGTTT -3′ 
               
               
                   
               
               
                   964 
                 5′- AACACTGTTGCAGGATCTCT[A]ATAATCACTATGTACACTTC -3′ 
               
               
                   
               
               
                   965 
                 5′- AACTCCCCAGCTAAACACCC[A]TAAGACTTCATACAACACAA -3′ 
               
               
                   
               
               
                   966 
                 5′- TAAATGCTTATCCATTTAGT[G]ACAGGAAAAATGAGACAACT -3′ 
               
               
                   
               
               
                   967 
                 5′- GTATGCTTTCCATCGAAAAA[G]TACTCTATTAAACAGCTTAG -3′ 
               
               
                   
               
               
                   968 
                 5′- TATACAGGAGTCATCCCCTA[T]GTTGACACTGGTAAGTTGTA -3′ 
               
               
                   
               
               
                   969 
                 5′- TCAAGTTTAAGCTGCTATGT[C]CCTTATTTTTAACTTTTGTT -3′ 
               
               
                   
               
               
                   970 
                 5′- ATATAATTTATATTACAATG[T]AAAAGCTTCTTTAATACTAA -3′ 
               
               
                   
               
               
                   971 
                 5′- GATGGGGAGGAAGAGAAGGC[A]TTGGTCTTGCAGTCTTGTCT -3′ 
               
               
                   
               
               
                   972 
                 5′- AATGGTAAGCATCTATTTTG[C]AGTCCACTCTACTGAGCTAA -3′ 
               
               
                   
               
               
                   973 
                 5′- TTTATATATGATATCATCAT[T]AAGCACTTTCTATAAGCTGA -3′ 
               
               
                   
               
               
                   974 
                 5′- AACAATCTGTGAACACTTGT[C]ATATGCTTACTGTAAGTGTG -3′ 
               
               
                   
               
               
                   975 
                 5′- ACTATATGTCATGTCTACAG[G]CTGTCTCCTAAGAGTAGAGG -3′ 
               
               
                   
               
               
                   976 
                 5′- TGCAAACATTGGGAAACCAC[A]GTAGGGGGGAGCAGGACTCT -3′ 
               
               
                   
               
               
                   977 
                 5′- TACCATGGACAGCAGCGCTG[T]CCCCACRAACGCCAGCAATT -3′ 
               
               
                   
               
               
                   978 
                 5′- ACTTGTCCCACTTAGATGGC[G]ACCTGTCCGACCCATGCGGT -3′ 
               
               
                   
               
               
                   979 
                 5′- GCATTTCACATTCACATGTA[A]TATTTGAATATACACATCAA -3′ 
               
               
                   
               
               
                   980 
                 5′- TTGAGTCTCCTTCCAATTAA[A]TCATGGAACATCAGAGCCAT -3′ 
               
               
                   
               
               
                   981 
                 5′- TCTTTTGTGGAAATGTGATG[T]ATTTGTTTATATGCAGACAA -3′ 
               
               
                   
               
               
                   982 
                 5′- ACCAGACTTAGGAGAGATAT[G]TCTCACTGTAGAACCAGTGC -3′ 
               
               
                   
               
               
                   983 
                 5′- CTCTGGTCAAGGCTAAAAAT[G]AATGAGCAAAATGGCAGTAT -3′ 
               
               
                   
               
               
                   984 
                 5′- AGCCAAAGTTCAGTTCTCCA[A]TTCATCTGAGCTCAGGCCCA -3′ 
               
               
                   
               
               
                   985 
                 5′- GGTATCRTGGGTCCTTTCRAGTAC[C]AACCGCCTTAGGCTGGAAGC -3′ 
               
               
                   
               
               
                   986 
                 5′- TTTTACCGAAGGCTGTGTCT[C]GTAAGCACCCCCGAGCAACT -3′ 
               
               
                   
               
               
                   987 
                 5′- CTACTCCGGCACCCAGTGGG[C]TGGTAGTCCTGTTGGCAGGA -3′ 
               
               
                   
               
               
                   988 
                 5′- CCAAGAAGCGCGCGGCGAGA[A]TGCAAGGTGGGGGCCCCGCC -3′ 
               
               
                   
               
               
                   989 
                 5′- CTCTCGCCGCGCGCTTCTTG[A]TCCCTGAGACTTCGAACGAA -3′ 
               
               
                   
               
               
                   990 
                 5′- GAGCAGAGGGGCAGGTCCCG[G]CCGGACGGCGCCCGGAGCCC -3′ 
               
               
                   
               
               
                   991 
                 5′- AGAGCGGATTGGGGGTCGCG[G]GTGGTAGCAGGAGGAGGAGC -3′ 
               
               
                   
               
               
                   992 
                 5′- TGGGGATTCAGAGCACCCAC[C]CGCAGCACCTCCCTCCTCTG -3′ 
               
               
                   
               
               
                   993 
                 5′- GGGTCAGTCCGGACAGCCCC[G]GTCGCTTGTTACCTAGCATC -3′ 
               
               
                   
               
               
                   994 
                 5′- CTGGGTGCGCTGGCCGAGGC[A]TACCCCTCCAAGCCGGACAA -3′ 
               
               
                   
               
               
                   995 
                 5′- GACATGGCCAGATACTACTC[A]GCGCTGCGACACTACATCAA -3′ 
               
               
                   
               
               
                   996 
                 5′- CTGACAATGTCTGTGGCAAC[G]CTGCAGTTTACTCCTTGGTT -3′ 
               
               
                   
               
               
                   997 
                 5′- CAGACACCCACTCCTATGTG[C]GTTTCTGAAAATTACAGGGT -3′ 
               
               
                   
               
               
                   998 
                 5′- TCCAGATATGGAAAACGATC[T]AGCCCAGAGACACTGATTTC -3′ 
               
               
                   
               
               
                   999 
                 5′- ATTTCAATTTAGAGTCAGGG[A]CTCACTCTATGCTCCCCTGA -3′ 
               
               
                   
               
               
                 1,000 
                 5′- TGGAAAGAGGTGCCCACCAA[C]GTCTAAGTGTTAAACATTGA -3′ 
               
               
                   
               
               
                 1,001 
                 5′- TATCATGCATTCAAAAGTGT[G]TCCTCCTCAATGAAAAATCT -3′ 
               
               
                   
               
               
                 1,002 
                 5′- TGAAAAATCTATTACAATAG[C]GAGGATTATTTTCGTTAAAC -3′ 
               
               
                   
               
               
                 1,003 
                 5′- TATTTCTCAAACATTTTCAG[T]TTTAGAATGGGAATAGGTTT -3′ 
               
               
                   
               
               
                 1,004 
                 5′- GTGCCTTTAAACCTATTCTA[T]AACCTATTTAAACGTATTTC -3′ 
               
               
                   
               
               
                 1,005 
                 5′- AGGGCTGCCTGGTAAGCTGA[G]TCAGGGTGCCTGGCTGCCGC -3′ 
               
               
                   
               
               
                 1,006 
                 5′- AACGCCACTTGTGACTGCTC[A]TTACCTTTCAGTTGTGTCCC -3′ 
               
               
                   
               
               
                 1,007 
                 5′- ATGTTGGGATTTAACTTTCT[A]TTATATGTCAGACTCACTTA -3′ 
               
               
                   
               
               
                 1,008 
                 5′- TGTGTGTTTTAAATCTTTGC[A]CTTAAATGTTTTTGATTTCT -3′ 
               
               
                   
               
               
                 1,009 
                 5′- GAAGCTTCCCTCCGACAGGC[A]GCCCCGCACTAAGGTAGGGA -3′ 
               
               
                   
               
               
                 1,010 
                 5′- CTAATGGTTGGAAACGCCAG[T]CTTTGGTGAAAACAGAAAGT -3′ 
               
               
                   
               
               
                 1,011 
                 5′- TTCAAGAATTCAACTGCAGA[C]TGAAAATATTTGGAGAAAAA -3′ 
               
               
                   
               
               
                 1,012 
                 5′- AACCTAGCCACAGAGCCCGA[C]GCGATGTGTCCTTGTCGAGA -3′ 
               
               
                   
               
               
                 1,013 
                 5′- GCCTCCTTTGCTGCCCTCAC[G]ATCTCTTCCTGTGACACCAC -3′ 
               
               
                   
               
               
                 1,014 
                 5′- CTCTGCACCTTCAGGTTCAG[A]CCCTTCAAGATCTACCAGGA -3′ 
               
               
                   
               
               
                 1,015 
                 5′- ACAAGCTAGTTACCTTTTAT[C]GTTCAGTTTAAAAAAGTTCT -3′ 
               
               
                   
               
               
                 1,016 
                 5′- CGGTCCCCTTCAAGATCCAT[T]CCGACCTGAAGAGAAACCGC -3′ 
               
               
                   
               
               
                 1,017 
                 5′- TGCTCTTCAAAAAAACCAGA[T]TGAATATTTTTAAAAGTAAT -3′ 
               
               
                   
               
               
                 1,018 
                 5′- GTTACTTGTAGGGGGAGGGT[A]GAGGGAAATCTGGGCAAATG -3′ 
               
               
                   
               
               
                 1,019 
                 5′- GGGCTTCTATCCCCGAACCC[C]GGGCCCTGGTGCCACTCAAG -3′ 
               
               
                   
               
               
                 1,020 
                 5′- TCCCAYTTAAGAGCTATTCT[T]CTATCCTTCCCTGTAAACAA -3′ 
               
               
                   
               
               
                 1,021 
                 5′- TGGCAGACACAGGACAGGGA[G]CGCTGCTTATGTCTCCGAGG -3′ 
               
               
                   
               
               
                 1,022 
                 5′- AACCCATCCTCGTGGTAATC[G]TCCCTGGTAAGAAACACACA -3′ 
               
               
                   
               
               
                 1,023 
                 5′- CATTTCTAATTACCAGCTTC[T]TACTTGGCACTTTCAATTTT -3′ 
               
               
                   
               
               
                 1,024 
                 5′- CCACAGCGGCTTCCTGCCAT[T]GATGAGGCTGATTTCTGCCT -3′ 
               
               
                   
               
               
                 1,025 
                 5′- TGCATCCTCTGCTTCTCCTC[G]AACCGTGCTTCACAGCTGCC -3′ 
               
               
                   
               
               
                 1,026 
                 5′- GGGGCCAAAGGAATATTTAG[C]TGAAGGGGGAGAGAGGCCAC -3′ 
               
               
                   
               
               
                 1,027 
                 5′- ACTTTGTGTGTACATGTGGA[G]GGAAGTATTTGACATTTTGA -3′ 
               
               
                   
               
               
                 1,028 
                 5′- ACTTGTGTCCCCCAAAATCA[T]ATATTGAAGTTAAAACCTCC -3′ 
               
               
                   
               
               
                 1,029 
                 5′- TAGCCATGGCAGAAGACATA[C]TCTCTACACCTTATGCATGG -3′ 
               
               
                   
               
               
                 1,030 
                 5′- GACAGAGAAGGTATGTCCAC[G]CACACTAGACATACTGCATG -3′ 
               
               
                   
               
               
                 1,031 
                 5′- AGTATTGATCAGTGGCGGGA[C]ACAGTTTGAAGGTAGAGGGA -3′ 
               
               
                   
               
               
                 1,032 
                 5′- GCTGTATCTTGGGGGAAGTG[T]GTTCTTGAGAGCTGTGTAAG -3′ 
               
               
                   
               
               
                 1,033 
                 5′- GGCCGTCCTCATCTTCACAC[A]CTGTTCTCCTTCTATGTGGG -3′ 
               
               
                   
               
               
                 1,034 
                 5′- TAGCAGGTGGCACAACTGGC[G]CTGGGAACCGGGGGTCCCTT -3′ 
               
               
                   
               
               
                 1,035 
                 5′- GGCCCCCCGTGCAGGGAGGG[T]TTCAGGCTGCGGCAGGTAGG -3′ 
               
               
                   
               
               
                 1,036 
                 5′- TACTATACAAATAAAAAAAT[T]AAAACCCAACCTCAAGCTGT -3′ 
               
               
                   
               
               
                 1,037 
                 5′- CGAATGCTGAGAACTTGCCA[T]GCTCTCTCCCCAGGGCCCCA -3′ 
               
               
                   
               
               
                 1,038 
                 5′- GCCTCCCCCTGTGATCTCTC[G]GTCCTCTCCGCATTCCTGGG -3′ 
               
               
                   
               
               
                 1,039 
                 5′- TTCCCTTTGTTTTCCCTTTC[T]TCCAGCTCCAGGCCAGGCTT -3′ 
               
               
                   
               
               
                 1,040 
                 5′- TGCGCTCTGGGCTAGACACT[C]TGATAGGTGCTGGGATTACA -3′ 
               
               
                   
               
               
                 1,041 
                 5′- TGGAAAACAGATCCAGACAG[T]TTCAGTTATGTGTCTGAGAA -3′ 
               
               
                   
               
               
                 1,042 
                 5′- CCCTACTACCCCTACAACTA[T]ACGAGCGGCGCTGCCACCGG -3′ 
               
               
                   
               
               
                 1,043 
                 5′- GCATGCCTTTTCAAAAACAC[G]TTCAAGACCTGAAAATAAAA -3′ 
               
               
                   
               
               
                 1,044 
                 5′- TACTGCTGTGGCCTGAATCC[A]TGATTAAAGGAAATGCTAAG -3′ 
               
               
                   
               
               
                 1,045 
                 5′- TACACAAGTCACTGGGTGAC[G]TCTGTAGCTCCACCAACCTG -3′ 
               
               
                   
               
               
                 1,046 
                 5′- CTCTGTCTAGGTGCATAGAA[C]TGTGTACATATACATACACA -3′ 
               
               
                   
               
               
                 1,047 
                 5′- AGTCTGCAAATGTGTTTTTT[A]TGTGCTAAATAGCTCAAAGT -3′ 
               
               
                   
               
               
                 1,048 
                 5′- TAAGTTTGGTTGATGAGTCT[A]TCTCTCTAGACTGCAAGCTC -3′ 
               
               
                   
               
               
                 1,049 
                 5′- CACAGAAGTGGGCATTCTGA[A]AGGCCTCTAATTTTCCTCTA -3′ 
               
               
                   
               
               
                 1,050 
                 5′- TTAAAACAGCGACCCCATAC[G]TGCATTAGTTAAAACTTTCT -3′ 
               
               
                   
               
               
                 1,051 
                 5′- GCAGATTGAGGTAAATTCAT[C]GTTAATGTCATCACAGCAAT -3′ 
               
               
                   
               
               
                 1,052 
                 5′- CAAAACAGAATCCCAAGAGC[G]ATATTTTAACTCAACAAACA -3′ 
               
               
                   
               
               
                 1,053 
                 5′- AGAGTTCTTATGGTTCTCTT[T]GGTAGTTTTTCTTTAGCTGG -3′ 
               
               
                   
               
               
                 1,054 
                 5′- CTTTCATTCTTGTCGTTGGC[A]TCTCTGTTCTGATAAAAAGA -3′ 
               
               
                   
               
               
                 1,055 
                 5′- GGAGGCAATGTCTGATTTGC[C]TAGGGCTCAGGGGAGAGATG -3′ 
               
               
                   
               
               
                 1,056 
                 5′- AGGTTCAGCAGAAAAGAACC[C]AGGAAAAAAGTCTAGGAAAG -3′ 
               
               
                   
               
               
                 1,057 
                 5′- GATGGGCCTTCTGATAAGGA[G]CGCTGCCAAAAGTTCAAATG -3′ 
               
               
                   
               
               
                 1,058 
                 5′- ATTCCTTCCTTTCCCTGTTT[G]TACATACCTTACAGATACTG -3′ 
               
               
                   
               
               
                 1,059 
                 5′- TCTGTTTCAGTCTCAAGGAG[C]CTGAAAAGGTGAATTCCTGT -3′ 
               
               
                   
               
               
                 1,060 
                 5′- CAGTCTTGTGAGAACATTCT[C]GCCATCTGTACTTTGCATTT -3′ 
               
               
                   
               
               
                 1,061 
                 5′- CCACACCTGGCCTGAACTCT[T]CTTTAAAAACTGCATGCTGA -3′ 
               
               
                   
               
               
                 1,062 
                 5′- TCATGCATAGATGGTGTAGC[T]TTAGAAAACTCAGGCCTAGC -3′ 
               
               
                   
               
               
                 1,063 
                 5′- AGGTGGATTTTTTTAAGAAG[T]ATATTCATACAACTGAATAT -3′ 
               
               
                   
               
               
                 1,064 
                 5′- GCCTGATATTCTTTCCCTAT[T]AAATTGCTTCCTCATCTAGG -3′ 
               
               
                   
               
               
                 1,065 
                 5′- GAAGAAGCTGTCAGAATTGC[G]AGGGAAATTGGTAAGTCCTT -3′ 
               
               
                   
               
               
                 1,066 
                 5′- ACTGTGCCCACCCAAGTTTG[C]GTTTTGAAAAGATTGGTCAA -3′ 
               
               
                   
               
               
                 1,067 
                 5′- ATGGCATACAGCCTGGGTGA[C]ATTTTTAAACATAAGTGAAA -3′ 
               
               
                   
               
               
                 1,068 
                 5′- GGGAAAATGTTCATTTAAGT[G]TAAAACATGAAATGGTATTC -3′ 
               
               
                   
               
               
                 1,069 
                 5′- CTTGTTAGTTCAGGTCTCTT[C]CAGATGAGGAAGAGAGATTA -3′ 
               
               
                   
               
               
                 1,070 
                 5′- AAATGGACAACAAAAGTCAC[T]GGAAAAAAGGGAAAAAAAGA -3′ 
               
               
                   
               
               
                 1,071 
                 5′- TGAGAAATAAGTGATGTCAT[A]CATTTTTGGTTGTGGATCAT -3′ 
               
               
                   
               
               
                 1,072 
                 5′- TGTGGTTCTCCCTTCACAGT[T]GAATACAAGGGCTTTTATAT -3′ 
               
               
                   
               
               
                 1,073 
                 5′- TAATAAGTGGTTATGCCAAG[G]GGTCCCTGCAGCTCAGAGGC -3′ 
               
               
                   
               
               
                 1,074 
                 5′- TCTTTGGGCCTCCACCCCCT[T]GTCTCTAGTGGACATTTGAG -3′ 
               
               
                   
               
               
                 1,075 
                 5′- AAAGGAAGCTGGGCGTCCTC[T]GGGCCCCCCAACACACGTCC -3′ 
               
               
                   
               
               
                 1,076 
                 5′- CTAACACAGTTGCGAACATC[A]GCAGAGCCGTCGGGAGCCAC -3′ 
               
               
                   
               
               
                 1,077 
                 5′- TTGATGATGATGTCGATGCC[A]AAGAGTGACACGCCCAGTGC -3′ 
               
               
                   
               
               
                 1,078 
                 5′- CTTCACAGCGCCGCAACAAT[T]ATGCATGAGGGAGTGATTCG -3′ 
               
               
                   
               
               
                 1,079 
                 5′- GGCCACAGCTGGCCAGTCTC[T]TTGTGCTTTGAATCTCCAGC -3′ 
               
               
                   
               
               
                 1,080 
                 5′- TGCAGCGTGCGGCAGTGCTT[C]GTTCTTCTTTAAGATGAAAT -3′ 
               
               
                   
               
               
                 1,081 
                 5′- CCTACACAGGAAGCCCCGGA[A]CCACAGCAATTCTCCCTGCC -3′ 
               
               
                   
               
               
                 1,082 
                 5′- TGTGCTCTGGCCAGGGGCCT[T]GACCTCATTCTGTTGGTGGT -3′ 
               
               
                   
               
               
                 1,083 
                 5′- TCGCCCAGGCTGACCACAAG[T]TCCAAACAGGACTTTCTTGT -3′ 
               
               
                   
               
               
                 1,084 
                 5′- TGCCCAAACAGTATCAAAAG[C]GGATGTTTATCACAATACTA -3′ 
               
               
                   
               
               
                 1,085 
                 5′- TTAGCAACAAAATCCTGAAG[C]CACTTCTAGACCATAACCCA -3′ 
               
               
                   
               
               
                 1,086 
                 5′- CAGAGGGCAGGGCCCACACC[A]TACCCCACAGAAGCCCAGGA -3′ 
               
               
                   
               
               
                 1,087 
                 5′- GGGTACAGCCCAGCATGGCC[A]CAGGGGTCCCTGATGGGAAT -3′ 
               
               
                   
               
               
                 1,088 
                 5′- GACTGCCAGGTGTGGACACA[C]GCTCGTCAAGTGGTGAAGAA -3′ 
               
               
                   
               
               
                 1,089 
                 5′- CACACGGACGCTTCCTCCTA[C]GTGAAGTTCTGTTTGCTCCC -3′ 
               
               
                   
               
               
                 1,090 
                 5′- ATGGTCATATTATGCATGCA[T]GTTTTTGATTTCAAGAATGC -3′ 
               
               
                   
               
               
                 1,091 
                 5′- ATGCGGTGCTCGGTAACTGT[T]CATCCGATGCAGGCCTCACT -3′ 
               
               
                   
               
               
                 1,092 
                 5′- ACCAGAATTATCACAGCACC[C]TCTCATTCCCAGCGCGTCCT -3′ 
               
               
                   
               
               
                 1,093 
                 5′- TGATCATGGTCACTGCCCTG[A]GTTCAAATAATGCGAGCTGA -3′ 
               
               
                   
               
               
                 1,094 
                 5′- AGGACAACATGCCATTTGTC[C]AAACGTTTTAAAGATATGAT -3′ 
               
               
                   
               
               
                 1,095 
                 5′- GGGGGAAGCTGGGTGCATGC[A]GAGCACCGTGGAGTCTGGGA -3′ 
               
               
                   
               
               
                 1,096 
                 5′- CCTTGAAGTCACCCGGCCCC[C]ATGCAAGGTGCCCACATGTG -3′ 
               
               
                   
               
               
                 1,097 
                 5′- TTTGGAAGGAAAACGTGGCG[G]GTGGGCGTATTCTCCAGAAG -3′ 
               
               
                   
               
               
                 1,098 
                 5′- TCCCAGACCAGACCTTGCCC[G]ATGACGTTGTTGGTAATGCT -3′ 
               
               
                   
               
               
                 1,099 
                 5′- TGAGATCCCCCGGACAACAC[G]CTCCACCTTCCCATGGAGCT -3′ 
               
               
                   
               
               
                 1,100 
                 5′- TTGTTTGTGTCTGTCTCAAA[T]CCAAAGGGGTGGCTCAGCCT -3′ 
               
               
                   
               
               
                 1,101 
                 5′- GAACCTCCCAGGGGGCAGAA[T]AAAAAGTCAACAAGCTGGAA -3′ 
               
               
                   
               
               
                 1,102 
                 5′- CAAACGTTGCTGAAGTCTCC[G]CGACCTTTATTGTTTTGCCC -3′ 
               
               
                   
               
               
                 1,103 
                 5′- GTTCCCTGACCAGGAGTCCA[G]TAGGCAATAGTCTATTAACT -3′ 
               
               
                   
               
               
                 1,104 
                 5′- TTTGCTCATGCACCTGCCTT[A]CCTTTGTCATCACAACAGAA -3′ 
               
               
                   
               
               
                 1,105 
                 5′- ACCTCCTTCCCCGTGCKCCA[T]GAGGAGCGGGCTGCACCTTG -3′ 
               
               
                   
               
               
                 1,106 
                 5′- GCTGAAACCCGATTCCTACC[G]GGTGACGCTGAGACCGTACC -3′ 
               
               
                   
               
               
                 1,107 
                 5′- TCCTGCTCGACCTGCTCCTC[T]AGCTGTGCAATCTTGGCCTC -3′ 
               
               
                   
               
               
                 1,108 
                 5′- TCCAGCGCCGCGATGGTGGA[T]TTGAACTTGGACTTGACGGC -3′ 
               
               
                   
               
               
                 1,109 
                 5′- TACGAGGAGAAGGCGGCCGC[T]TATGATAAACTGGAAAAGAC -3′ 
               
               
                   
               
               
                 1,110 
                 5′- TTCCGCAGCTTGAGGTAGGC[A]GCGCAGTTCCTCTGAATCAC -3′ 
               
               
                   
               
               
                 1,111 
                 5′- CCTGTGGCTGGTACCTTCCC[G]GCATAATGGATGATGGAGAA -3′ 
               
               
                   
               
               
                 1,112 
                 5′- ATGATTGCCATGGCCTCCAC[A]GTTTCCTGGAACATCTCATC -3′ 
               
               
                   
               
               
                 1,113 
                 5′- CCAGAACCACCAACATCTTC[G]GTCTCTGTATTCAATTTTAT -3′ 
               
               
                   
               
               
                 1,114 
                 5′- TTTTCCCAGCTGTAAAAGGG[G]GCTAATAATAGCTCTTGCGG -3′ 
               
               
                   
               
               
                 1,115 
                 5′- GATACCTGACTCCAGGAGCC[G]TCACTTTACAACCTGAGATT -3′ 
               
               
                   
               
               
                 1,116 
                 5′- TTCTTGCCCTTGTACATGTC[A]ACGATCTTCTCCGAGTAGAT -3′ 
               
               
                   
               
               
                 1,117 
                 5′- ATCATGCTCAGTGAAACAAA[T]CAGAAAGGCCACACGCTCTA -3′ 
               
               
                   
               
               
                 1,118 
                 5′- ACCTGGTCAACAGCTTCCCT[C]AGGATTTTACTGCCAAGCCA -3′ 
               
               
                   
               
               
                 1,119 
                 5′- CACCCAGTCTGACCTTCACT[C]TTTTGTTGATGGGGCTGAGC -3′ 
               
               
                   
               
               
                 1,120 
                 5′- GCTGCTGGGGGTGGGTGCTT[C]GATCCTGGTGAAATGGCCTC -3′ 
               
               
                   
               
               
                 1,121 
                 5′- AGAATCATCTTCTCCTTTCC[C]TCACCTGATACCCAGCTTGA -3′ 
               
               
                   
               
               
                 1,122 
                 5′- CCTGTCAGGCCTGACGGGGA[A]GAACCACTGCACCACCGAGA -3′ 
               
               
                   
               
               
                 1,123 
                 5′- GGCTATGAATATAGTACCTG[G]AAAAATGCCAAGACATGATT -3′ 
               
               
                   
               
               
                 1,124 
                 5′- CTTTTGGGAATTTCCTCTCC[T]CTTGGCACTCGGAGTTGGGG -3′ 
               
               
                   
               
               
                 1,125 
                 5′- CAAGCCATGGCAGCGGACAG[T]CTGCTGAGAACACCCAGGAA -3′ 
               
               
                   
               
               
                 1,126 
                 5′- GACCAGTGAACTTCATCCTT[G]TCTGTCCAGGAGGTGGCCTC -3′ 
               
               
                   
               
               
                 1,127 
                 5′- TCAGTATAGATGCACCCATC[C]TAAGCCTAACTACATTGTAT -3′ 
               
               
                   
               
               
                 1,128 
                 5′- GTGAGCGTGCCATCAGCCCA[A]TGGAGGGGCTTAGGTCTGCA -3′ 
               
               
                   
               
               
                 1,129 
                 5′- GGTGCCATCCAGTGCCCTGA[C]AGTCAGTTCGAATGCCCGGA -3′ 
               
               
                   
               
               
                 1,130 
                 5′- GGCCCGTAGCCCTCACGTGG[C]TGTGAAGGACGTGGAGTGTG -3′ 
               
               
                   
               
               
                 1,131 
                 5′- TCAGGCCTCCCTAGCACCTC[T]CCCTAACCAAATTCTCCCTG -3′ 
               
               
                   
               
               
                 1,132 
                 5′- AGCCATGAGTTTCCACCAGC[G]GCAGAGTGAGTCCTGAGCAC -3′ 
               
               
                   
               
               
                 1,133 
                 5′- ATTGCAGAGAATGGAAGAAT[G]TGAAGAACTGAGTGACAAGG -3′ 
               
               
                   
               
               
                 1,134 
                 5′- AGCTACTGGGTAGAATTTTA[T]GTAGTAACTAGGTAGACACT -3′ 
               
               
                   
               
               
                 1,135 
                 5′- GGATGGCATAGCGAGAATAC[C]AATCTAGGAAGCGACTGGAC -3′ 
               
               
                   
               
               
                 1,136 
                 5′- GCTTTCCTGCTATCATAGCC[T]ACTTAAGTAGCTGTATTAGG -3′ 
               
               
                   
               
               
                 1,137 
                 5′- ATGAGGAAGAGAGAGACGAG[A]TGGGGTGACTCATGCCTGAA -3′ 
               
               
                   
               
               
                 1,138 
                 5′- TTTCTTTGAGACAGGGTCTC[G]CTCTGTTACCCAAGCTGGRA -3′ 
               
               
                   
               
               
                 1,139 
                 5′- TCATTAGCAGGGTGATGGTG[G]GGCTGAGATGGGCAGGGCCA -3′ 
               
               
                   
               
               
                 1,140 
                 5′- ATTGCCAACATAGCTGTTCA[C]ACCTAGAACACCTTTTCCTT -3′ 
               
               
                   
               
               
                 1,141 
                 5′- CACAACCTCGGTAAGGCTGG[C]GATCTTCAAGCCAGTCCGAT -3′ 
               
               
                   
               
               
                 1,142 
                 5′- GTCCGTTGTCCACGTTCTAC[T]TCCACCCCACTAACTGAACG -3′ 
               
               
                   
               
               
                 1,143 
                 5′- AGGCCAGGGGTCTGGATGCA[T]ATAGCGTTCCCCTAGCCTCT -3′ 
               
               
                   
               
               
                 1,144 
                 5′- TGCAGAGGTGTGGGCCCCTG[A]GGACCCAGAAGTCCAGCCAC -3′ 
               
               
                   
               
               
                 1,145 
                 5′- GGGTGAAGTAAAGTGGGCAG[A]GTGATTTAGCAGAGTGGTCA -3′ 
               
               
                   
               
               
                 1,146 
                 5′- GGCACCTGTCATAGTCTTGC[T]GAAAGATGACAACCCCTGGT -3′ 
               
               
                   
               
               
                 1,147 
                 5′- CGCAGCCCAGGATGATCTGT[G]CGGGACAGAGGCAGCGGCCT -3′ 
               
               
                   
               
               
                 1,148 
                 5′- TCGGAACAGCGAGTCCTCTG[G]CGTCGAGAGCAGGGAGGGGT -3′ 
               
               
                   
               
               
                 1,149 
                 5′- TTTGCCCAGTGACGCAGCAT[C]CCAGGCTGAGATTGCAGAAT -3′ 
               
               
                   
               
               
                 1,150 
                 5′- GCCCCCTCTGCAGGTCCCCT[T]GGTGTACTCTGAGGTGGGAA -3′ 
               
               
                   
               
            
           
         
       
     
     REFERENCES CITED IN EXAMPLE 2 
     
         
         1. Fortin D F, Califf R M, Pryor D B, Mark D B (1995) The way of the future redux. Am J Cardiol 76: 1177-1182. 
         2. Smith L R, Harrell F E, Rankin J S, Califf R M, Pryor D B, et al. (1991) Determinants of Early Versus Late Cardiac Death in Patients Undergoing Coronary-Artery Bypass Graft-Surgery. Circulation 84:245-253. 
         3. Kong D F, Shaw L K, Harrell F E, Muhlbaier L H, Lee K L, et al. (2002) Predicting survival from the coronary arteriogram: an experience-based statistical index of coronary artery disease severity. Journal of the American College of Cardiology 39(Suppl A): 327A. 
         4. Felker G M, Shaw L K, O&#39;Connor C M (2002) A standardized definition of ischemic cardiomyopathy for use in clinical research. J Am Coll Cardiol 39: 210-218. 
         5. Carlson C S, Eberle M A, Rieder M J, Yi Q, Kruglyak L, et al. (2004) Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet. 74: 106-120. 
         6. Xu H, Gregory S G, Hauser E R, Stenger J E, Pericak-Vance M A, et al. (2005) SNPselector: a web toot for selecting SNPs for genetic association studies. Bioinformatics 21: 4181-4186. 
         7. Abecasis G R, Cookson W O (2000) GOLD—graphical overview of linkage disequilibrium. BioInformatics 16: 182-183. 
         8. Barrett J C, Fry B, Maller J, Daly M J (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265. 
         9. Schaid D J, Rowland C M, Tines D E, Jacobson R M, Poland G A (2002) Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am J Hum Genet. 70: 425-434. The results are shown in Tables 3-5 below.