Patent Publication Number: US-2023157819-A1

Title: Valve clamping device and valve clamping system

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
     The present disclosure claims all the benefits of the Chinese patent application No. 202010192630.9, filed on Mar. 18, 2020 to the China National Intellectual Property Administration of the People&#39;s Republic of China, entitled “Valve Clamping Device And Valve Clamping System”; the Chinese patent application No. 202110057563.4, filed on Jan. 15, 2021 to the China National Intellectual Property Administration of the People&#39;s Republic of China, entitled “Adequately Fitted Valve Clamping Device And Valve Clamping System”; the Chinese patent application No. 202110057559.8, filed on Jan. 15, 2021 to the China National Intellectual Property Administration of the People&#39;s Republic of China, entitled “Adaptive Valve Clamping Device And Valve Clamping System”; the Chinese Utility Model application No. 202120115656.3, filed on Jan. 15, 2021 to the China National Intellectual Property Administration of the People&#39;s Republic of China, entitled “Adequately Fitted Valve Clamping Device And Valve Clamping System”; the Chinese Utility Model application No. 202021717762.0, filed on Aug. 17, 2020 to the China National Intellectual Property Administration of the People&#39;s Republic of China, entitled “Valve Clamping Device And Valve Clamping System”; and the Chinese Utility Model application No. 202120119689.5, filed on Jan. 15, 2021 to the China National Intellectual Property Administration of the People&#39;s Republic of China, entitled “Adaptive Valve Clamping Device And Valve Clamping System”, which are explicitly incorporated herein by reference in their entirety. 
     FIELD 
     The present disclosure generally relates to the technical field of medical instruments, particularly to a valve clamping device and a valve clamping system. 
     BACKGROUND 
     Referring to  FIG.  1   , mitral valve MV is a one-way valve located between left atrium LA and left ventricle LV of the heart. A normal and healthy mitral valve MV can control blood to flow from the left atrium LA to the left ventricle LV while avoiding blood flowing from the left ventricle LV to the left atrium LA. The mitral valve MV comprises a pair of valve leaflets, called an anterior mitral leaflet AML and a posterior mitral leaflet PML. The anterior mitral leaflet AML and the posterior mitral leaflet PML are fixed to papillary muscles of the left ventricle LV through chordae tendineae. Under normal circumstances, when the left ventricle LV contracts, edges of the anterior mitral leaflet AML and the posterior mitral leaflet PML are completely coapted to avoid blood flowing from the left ventricle LV to the left atrium LA. Referring to  FIG.  2   , when the valve leaflet of the mitral valve MV or a related structure thereof changes organically or functionally, for example, chordae tendineae partially ruptures, the anterior mitral leaflet AML and the posterior mitral leaflet PML of the mitral valve MV are poorly coapted. Therefore, when the left ventricle LV contracts, the mitral valve MV cannot be completely closed, resulting in blood regurgitation from the left ventricle LV to the left atrium LA and thus a series of pathophysiological changes, called “mitral regurgitation”. 
     Mitral valve interposed clamping refers to treatment of mitral regurgitation by pulling the anterior mitral leaflet and the posterior mitral leaflet toward each other by a pair of rotatably connected closable clamp arms with a valve clamping device so as to reduce or eliminate a valve leaflet space. A valve clamping device in the related art adds an elastomer between two clamp arms, and valve leaflets on each side are clamped between one clamp arm and one side of an elastomer respectively. A space between the clamp arms on both sides is filled with the elastomer to reduce central regurgitation, and spacing of the valve leaflets is adapted by deformation of the elastomer so as to adjust pulling degree of the clamp arm to the valve leaflet. However, when the clamp arm is closed, the closer to a clamp arm connection, the smaller the space is. When the valve leaflet is gripped by the clamp arm, part of the valve leaflet fills and accumulates in the space, which will affect closing of the clamp arms. Meanwhile, if a valve leaflet filling condition cannot be found in time through a medical image, the clamp arm will damage the valve leaflet when an operator forcibly closes the clamping device. 
     SUMMARY 
     In an aspect, the present disclosure relates to a valve clamping device comprising: 
     a supporting portion provided along an axial direction; 
     a hollow adjusting portion, wherein at least a part of the supporting portion is provided in the adjusting portion, one end of the adjusting portion is sleeved outside the supporting portion, and the other end of the adjusting portion is movable with respect to the supporting portion; 
     a clamping portion surrounding an outside of the adjusting portion; and 
     a driving portion connected to the clamping portion to drive the clamping portion to be close to or away from the adjusting portion. 
     In some embodiments, the supporting portion comprises a first seat body and a second seat body connected along the axial direction, and the first seat body is provided in the adjusting portion; and the adjusting portion comprises a first end and a second end provided opposite along the axial direction, and a self-expanding body between the first end and the second end. 
     In some embodiments, the first end is fixedly sleeved outside the second seat body. 
     In some embodiments, the second end hangs freely with respect to the supporting portion to be movable with respect to the supporting portion. 
     In some embodiments, the second end is movably sleeved outside the first seat body and is movable along the axial direction with respect to the supporting portion. 
     In some embodiments, the second end is fixedly sleeved outside the first seat body, the first end is movably sleeved outside the second seat body and is movable along the axial direction with respect to the supporting portion. 
     In some embodiments, the first end is movably sleeved outside the second seat body and is movable along the axial direction with respect to the supporting portion. 
     In some embodiments, the second end is sleeved outside the first seat body and is movable along the axial direction with respect to the supporting portion. 
     In some embodiments, the second end hangs freely with respect to the supporting portion to be movable with respect to the supporting portion. 
     In some embodiments, the self-expanding body is an elastomer, and the adjusting portion is provided with an opening at the second end. 
     In some embodiments, the elastomer is of at least one structure selected from the group consisting of a mesh structure, a frame structure, a dense structure and a porous structure. 
     In some embodiments, the elastomer is of a mesh structure or a frame structure, and at least part of an outer surface and/or at least part of an inner surface of the elastomer are covered with a biocompatible film. 
     In some embodiments, the second end of the adjusting portion is a head with a central through hole, a part of the elastomer penetrates and is fixed in the head, and the central through hole forms the opening; or an edge of the second end is sleeved with a hollow sleeve structure to form the opening; or the edge of the second end is enclosed to form the opening. 
     In some embodiments, the elastomer is of a mesh structure, the elastomer is woven from a shape memory material, and a mesh wire woven to form the mesh structure is bent back at the second end to form the opening. 
     In some embodiments, the elastomer is of a frame structure, the frame structure is cut from a shape memory material, the frame structure comprises a plurality of supporting rods, the adjacent supporting rods are spaced apart from or cross-linked with each other, and proximal ends of a plurality of the supporting rods converge to form the opening. 
     In some embodiments, the elastomer is of a dense structure made of silica gel; or the elastomer is of a porous structure made of sponge; and an edge of the second end of the dense structure or the porous structure forms the opening. 
     In some embodiments, a diameter of at least a part of the self-expanding body in a natural state gradually increases from the first end of the adjusting portion to the second end of the adjusting portion. 
     In some embodiments, the self-expanding body has a recessed area connected to the second end, the recessed area is recessed toward the first end, and the second end is located between two end faces of the self-expanding body along an axis. 
     In some embodiments, the self-expanding body comprises a first section, a second section and a third section successively connected; 
     the first section extends from the second end of the adjusting portion toward a second end of the supporting portion, and the first section surrounds an outside of the second end of the supporting portion; the second section continues to extend radially outward from the first section; and the third section extends radially inward from the second section toward a first end of the supporting portion to the first end of the adjusting portion. 
     In some embodiments, the self-expanding body further comprises a bending section connected between the second end of the adjusting portion and the first section. 
     In some embodiments, a radial dimension of the second section of the self-expanding body ranges from 4 mm to 15 mm, and a radial dimension of the first end of the adjusting portion ranges from 1 mm to 5 mm. 
     In some embodiments, the self-expanding body comprises a plurality of first curved surfaces and a plurality of second curved surfaces along a circumferential direction, the first curved surface and the second curved surface are adjacent to each other, the two oppositely provided first curved surfaces face the clamping portion respectively, and an area of the second curved surface is less than an area of the first curved surface. 
     In some embodiments, the first seat body comprises an interface end connected to the second seat body and a free end provided oppositely to the interface end, and the free end is located in the adjusting portion. 
     In some embodiments, the self-expanding body is an elastomer, and the adjusting portion is provided with an opening at the second end; and a size of the opening is less than or equal to a size of the free end. 
     In some embodiments, a hollow sleeve structure is sleeved outside an edge of the end of the adjusting portion, and the sleeve structure is sleeved outside the supporting portion. 
     In some embodiments, the clamping portion comprises at least two clamp arms, the at least two clamp arms are symmetrically provided with respect to the adjusting portion, and the driving portion is connected to each of the clamp arms to drive each of the clamp arms to be close to or away from the adjusting portion. 
     In some embodiments, the supporting portion further comprises a base connected to the second seat body, each of the clamp arms is rotationally connected to the base, and there is axial spacing between the first end and a connecting position of the clamp arm and the base. 
     In some embodiments, the driving portion comprises a driving shaft, a connecting seat and at least two connecting rods; wherein one end of each of the connecting rods is connected to the clamping portion, and the other end of each of the connecting rods is pivotally connected to the connecting seat; and one end of the driving shaft is connected to the connecting base, and the other end of the driving shaft movably penetrates in the base. 
     In some embodiments, the valve clamping device further comprises a locking portion provided in the base, and the locking portion restricts relative movement of the driving shaft and the base. 
     In some embodiments, the driving portion comprises a driving shaft, an automatic closing unit and at least two connecting rods; the driving shaft movably penetrates in the supporting portion, one end of each of the connecting rods is rotationally connected to one of the clamp arms, and the other end of each of the connecting rods is rotationally connected to the driving shaft; and the automatic closing unit is connected to the clamp arm to cause the clamp arm to abut against the adjusting portion in a natural state. 
     In some embodiments, the driving portion comprises a driving shaft and at least two elastic driving arms, one end of the driving shaft movably penetrates in the supporting portion, one end of each of the elastic driving arms is fixedly connected to the other end of the driving shaft, and the other end of each of the elastic driving arms is respectively connected to one of the clamp arms; and the elastic driving arms are configured to cause the clamp arms to abut against the adjusting portion in a natural state. 
     In some embodiments, a terminal end of the clamp arm is provided with a flanging section which is a cambered surface overturned toward an outside of the terminal end of the clamp arm, and the self-expanding body protrudes from the flanging section in the axial direction after the clamp arm abuts against the adjusting portion. 
     In some embodiments, the self-expanding body is provided with an adaptation section corresponding to the flanging section, and a shape of the adaptation section toward the flanging section is complementary to the cambered surface. 
     In some embodiments, the valve clamping device further comprises a gripping portion provided between the clamping portion and the adjusting portion, the gripping portion is able to be close to or away from the adjusting portion, and when the gripping portion and the clamping portion are away from the adjusting portion, the gripping portion is at least partially accommodated in an inner surface of the clamping portion. 
     In another aspect, the present disclosure relates to a valve clamping device comprising: 
     a supporting portion which comprises a connecting end and a free end provided oppositely; 
     a hollow adjusting portion, at least a part of the supporting portion is provided in the adjusting portion, one end of the adjusting portion is sleeved outside the connecting end and connected to the supporting portion, and the other end of the adjusting portion hangs freely; 
     a clamping portion surrounding an outside of the adjusting portion; and 
     a driving portion connected to the clamping portion to drive the clamping portion to open or close around the adjusting portion. 
     In some embodiments, a free end of the supporting portion is within the adjustment portion. 
     In some embodiments, the adjusting portion comprises an elastomer, one end of the elastomer is connected to the supporting portion, and the other end of the elastomer has an opening and hangs freely. 
     In some embodiments, a size of the opening is less than or equal to a size of the free end. 
     In some embodiments, a proximal edge of the elastomer is sleeved with a hollow sleeve structure to form the opening. 
     In some embodiments, a proximal edge of the elastomer is enclosed to form the opening. 
     In some embodiments, the elastomer is of at least one structure selected from the group consisting of a mesh structure, a frame structure, a dense structure and a porous structure. 
     In some embodiments, when the elastomer is of the mesh structure or the frame structure, at least part of an outer surface of the elastomer is covered with a film. 
     In some embodiments, when the elastomer is of the mesh structure or the frame structure, the elastomer is woven or cut from a shape memory material. 
     In some embodiments, when the elastomer is the mesh structure, a mesh wire of the mesh structure is bent back at a proximal end to form the proximal edge. 
     In some embodiments, when the elastomer is of the frame structure, adjacent supporting rods of the frame structure are spaced apart from or cross-linked with each other, and the supporting rods of the frame structure converge at a proximal end to form the proximal edge. 
     In some embodiments, when the elastomer is of the dense structure, the dense structure is made of silica gel; when the elastomer is of the porous structure, the porous structure is made of sponge; and a proximal edge of the dense structure or the porous structure forms the opening. 
     In some embodiments, a distal end of the elastomer is fixedly sleeved on the supporting portion, or a hollow sleeve structure is sleeved outside a distal edge of the elastomer, and the sleeve structure is fixedly sleeved on the supporting portion. 
     In some embodiments, the clamping portion comprises at least two clamp arms, the at least two clamp arms are symmetrically provided with respect to the adjusting portion, and the driving portion is connected to each of the clamp arms to drive each of the clamp arms to rotate around the adjusting portion. 
     In some embodiments, the adjusting portion comprises a plurality of first curved surfaces and a plurality of second curved surfaces, the first curved surface and the second curved surfaces are adjacent to each other, the two oppositely provided first curved surfaces face one of the clamp arms respectively, and an area of the second curved surface is smaller than an area of the first curved surface. 
     In some embodiments, the valve clamping device further comprises a gripping portion provided between the clamping portion and the adjusting portion and being able to close or open with respect to the adjusting portion, and when both of the gripping portion and the clamping portion open, the gripping portion is at least partially accommodated in an inner surface of the clamping portion. 
     In some embodiments, the valve clamping device further comprises a base fixedly connected to the supporting portion, and the clamping portion is rotationally connected to the base. 
     In some embodiments, the driving portion comprises a driving shaft, a connecting seat and at least two connecting rods; wherein one end of each of the connecting rods is connected to the clamping portion, and the other end of each of the connecting rods is pivotally connected to the connecting seat; and one end of the driving shaft is connected to the connecting base, and the other end of the driving shaft movably penetrates in the base. 
     In some embodiments, the valve clamping device further comprises a locking portion provided in the base, and the locking portion restricts relative movement of the driving shaft and the base. 
     In still another aspect, the present disclosure provides an adequately fitted valve clamping device comprising: 
     a supporting portion with a certain axial length comprising a first end and a second end provided oppositely; 
     an adjusting portion comprising a first end and a second end provided oppositely and a self-expanding body between the first end and the second end of the adjusting portion; the first end of the adjusting portion is movably sleeved outside the supporting portion, the second end of the adjusting portion is sleeved outside the supporting portion and fixedly connected to the supporting portion, and the first end of the adjusting portion is located between the first end of the supporting portion and the second end of the adjusting portion; and a clamping portion provided on the outside of the supporting portion and being able to open or close with respect to the adjusting portion. 
     In some embodiments, a diameter of the self-expanding body in a natural state gradually increases from the first end of the adjusting portion to the second end of the adjusting portion. 
     In some embodiments, the self-expanding body is of a mesh structure made of a shape memory material. 
     In some embodiments, an outside and/or inside of the mesh structure is covered with a biocompatible film. 
     In some embodiments, the self-expanding body has a recessed area connected to the second end of the adjusting portion, and a terminal end of the recessed area extends toward the first end of the supporting portion to the second end of the adjusting portion, or the terminal end of the recessed area extends toward the second end of the supporting portion to the second end of the adjusting portion. 
     In some embodiments, the adequately fitted valve clamping device further comprises a fixing part, and the second end of the adjusting portion penetrates and is fixed in the fixing part to be fixedly connected to the supporting portion through the fixing part. 
     In some embodiments, the self-expanding body comprises a first section, a second section and a third section successively connected; 
     the first section extends from the second end of the adjusting portion toward a second end of the supporting portion, and the first section surrounds an outside of the second end of the supporting portion; the second section continues to extend radially outward from the first section; and the third section extends radially inward from the second section toward a first end of the supporting portion to the first end of the adjusting portion. 
     In some embodiments, the self-expanding body further comprises a bending section connected between the second end of the adjusting portion and the first section. 
     In some embodiments, a radial dimension of the second section of the self-expanding body ranges from 4 mm to 15 mm, and a radial dimension of the first end of the adjusting portion ranges from 1 mm to 5 mm. 
     In some embodiments, the valve clamping device further comprises a driving portion, the clamping portion comprises at least two clamp arms, the at least two clamp arms are symmetrically provided with respect to the adjusting portion, and the driving portion is connected to each of the clamp arms to drive each of the clamp arms to be close to or away from the adjusting portion. 
     In some embodiments, the first end of the supporting portion is provided with a base, each of the clamp arms is rotationally connected to the base, and there is axial spacing between the first end of the supporting portion and the first end of the adjusting portion. 
     In some embodiments, the driving portion comprises a driving shaft, a connecting seat and at least two connecting rods; one end of each of the connecting rods is rotationally connected to one of the clamp arms, and the other end of each of the connecting rods is rotationally connected to the connecting seat; and one end of the driving shaft is connected to the connecting seat, and the other end of the driving shaft movably penetrates in the base. 
     In some embodiments, the valve clamping device further comprises a locking portion provided in the base, and the locking portion restricts relative movement of the driving shaft and the base. 
     In some embodiments, the driving portion comprises a driving shaft, an automatic closing unit and at least two connecting rods; the driving shaft movably penetrates in the supporting portion, one end of each of the connecting rods is rotationally connected to one of the clamp arms, and the other end of each of the connecting rods is rotationally connected to the driving shaft; and the automatic closing unit is connected to the clamp arm to cause the clamp arm to abut against the adjusting portion in a natural state. 
     In some embodiments, the driving portion comprises a driving shaft and at least two elastic driving arms, one end of the driving shaft movably penetrates in the supporting portion, and one end of each of the elastic driving arms is fixedly connected to the other end of the driving shaft, the other end of each of the elastic driving arms is connected to one of the clamp arms; and the elastic driving arms are configured to cause the clamp arms to abut against the adjusting portion in a natural state. 
     In some embodiments, a terminal end of the clamp arm is provided with a flanging section, the flanging section is a cambered surface overturned toward an outside of the terminal end of the clamp arm, and the self-expanding body protrudes from the flanging section in the axial direction after the clamp arm abuts against the adjusting portion. 
     In some embodiments, the self-expanding body is provided with an adaptation section corresponding to the flanging section, and a shape of the adaptation section toward the flanging section is complementary to the cambered surface. 
     In some embodiments, the valve clamping device further comprises a gripping portion provided between the clamping portion and the adjusting portion and being able to close or open with respect to the supporting portion. 
     In still another aspect, the present disclosure relates to an adaptive valve clamping device comprising: 
     a supporting portion comprising a first seat body and a second seat body connected to the first seat body; 
     a hollow adjusting portion, wherein the first seat body is provided in the adjusting portion, the adjusting portion comprises a first end and a second end provided oppositely, and a self-expanding body between the first end and the second end, the first end of the adjusting portion is movably sleeved outside the second seat body and is able to move axially with respect to the second seat body, the second end of the adjusting portion hangs, and the first seat body is closer to the second end of the adjusting portion than the second seat body; and a clamping portion comprising at least two clamp arms, each of the clamp arms is rotationally connected to the supporting portion, a rotationally connected portion of the clamp arms is close to the first end of the adjusting portion, and the clamp arms rotate around the supporting portion to be close to or away from the adjusting portion. 
     In some embodiments, the first end of the adjusting portion is provided with a first head, and there is a clearance fit between an inner cavity surface of the first head and an outer surface of the second seat body. 
     In some embodiments, the clearance fit between the inner cavity surface of the first head and the outer surface of the second seat body ranges from 0.01 mm to 3 mm. 
     In some embodiments, the clearance fit between the inner cavity surface of the first head and the outer surface of the second seat body ranges from 0.05 mm to 1 mm. 
     In some embodiments, the clearance fit between the inner cavity surface of the first head and the outer surface of the second seat body ranges from 0.05 mm to 0.2 mm. 
     In some embodiments, a surface roughness of the inner cavity surface of the first head ranges from 0.1 μm to 2.5 μm, and/or a surface roughness of the outer surface of the second seat body ranges from 0.1 μm to 2.5 μm. 
     In some embodiments, the inner cavity of the first head is provided with a first rotation stop, the outer surface of the second seat body is provided with a second rotation stop corresponding to the first rotation stop, and the first rotation stop is detachably fittingly connected to the second rotation stop. 
     In some embodiments, the first head and the first rotation stop are integrally molded or separately connected, and the second seat body and the second rotation stop are integrally molded or separately connected. 
     In some embodiments, the first rotation stop comprises at least one plane surface and/or at least one cambered surface, and the second rotation stop comprises at least one plane surface and/or at least one cambered surface. 
     In some embodiments, the first rotation stop and the second rotation stop are of a polyhedron structure fittingly connected. 
     In some embodiments, one of the first rotation stop and the second rotation stop is a sliding groove extending axially, and the other is a protrusion fitting in the sliding groove. 
     In some embodiments, the supporting portion further comprises a third seat body connected to the second seat body, an end of the second seat body connected to the first seat body is provided with a limiting part, an inner diameter of the first head is less than an outer diameter of the limiting part, and the inner diameter of the first head is less than an outer diameter of the third seat body. 
     In some embodiments, the supporting portion further comprises a third seat body connected to the second seat body, an inner diameter of the first head is less than an outer diameter of the first seat body, and an inner diameter of the first head is less than an outer diameter of the third seat body. 
     In some embodiments, the at least two clamp arms are rotationally connected to the third seat body, and the at least two clamp arms are symmetrically provided in a circumferential direction with respect to the adjusting portion. 
     In some embodiments, the adaptive valve clamping device further comprises a driving portion comprising a driving shaft, a connecting seat and at least two connecting rods; one end of each of the connecting rods is connected to one of the clamp arms, and the other end of each of the connecting rods is pivotally connected to the connecting seat; and one end of the driving shaft is connected to the connecting seat, and the other end of the driving shaft movably penetrates in the third seat body. 
     In some embodiments, the driving portion further comprises a locking part provided in the third seat body, and the locking part is configured to limit relative movement of the driving shaft and the third seat body. 
     In some embodiments, the second end of the adjusting portion has an opening. 
     In some embodiments, the second end of the adjusting portion is further provided with a second head. 
     In some embodiments, the adaptive valve clamping device further comprises a gripping portion provided between the clamp arm and the adjusting portion and being able to be close to or away from the clamp arms, and the gripping portion is at least partially accommodated in an inner surface of the clamp arm in a natural state. 
     In still another aspect, the present disclosure relates to a valve clamping system comprising the valve clamping device of the above aspects and a delivery device, wherein the delivery device comprises: a pushing shaft with a certain axial length and a mandrel movably penetrating in the pushing shaft, the pushing shaft and the supporting portion are detachably connected, and the mandrel is connected to the driving portion to drive the clamping portion to open and close with respect to the supporting portion. 
     In still another aspect, the present disclosure relates to a valve clamping system comprising the valve clamping device of the above aspects and a delivery device, wherein the delivery device comprises: a pushing shaft with a certain axial length and a mandrel movably penetrating in the pushing shaft, the pushing shaft and the supporting portion are detachably connected, and the mandrel is configured to drive the clamp arms to rotate around the supporting portion. 
     In some embodiments, at least part of a supporting portion of a valve clamping device and a valve clamping system comprising the valve clamping device is provided in a hollow of an adjusting portion. One end of the adjusting portion is sleeved outside the supporting portion, the other end of the adjusting portion is movable with respect to the supporting portion, and the movable end is no longer completely limited by the supporting portion or other devices, which improves a deformation ability of the adjusting portion. Therefore, when the valve clamping device is radially compressed into the delivery device for in vivo delivery, the valve clamping device is not only easy to be compressed into a sheath, but also can adapt to different blood vessels during delivery in the blood vessel, so as to facilitate passage of the delivery device in the blood vessel, thereby reducing the damage to the vessel wall. In addition, after the valve clamping device is implanted, in a process of clamping the valve leaflet and the adjusting portion with the clamp arm, since the adjusting portion can be deformed, an elastic fit between the valve leaflet and the adjusting portion can be improved, and thus adaptability to physiological structures of valve leaflets in different patients can be improved. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       The drawings herein are incorporated into the specification and constitute a part of the specification. The drawings show examples conforming to examples of the present disclosure and are used to explain the principle of the present disclosure together with the specification. 
       In order to explain the technical solutions more clearly in the examples of the present disclosure or the related art, the drawings that need to be used in the description of the examples or the related art are briefly explained. Obviously, one skilled in the art can obtain other drawings based on these drawings without involving creative efforts. 
         FIG.  1    shows a schematic diagram of a normal state of a mitral valve; 
         FIG.  2    shows a schematic diagram of a mitral valve in the presence of a lesion; 
         FIG.  3    and  FIG.  4    show structural schematic diagrams of a valve clamping device in the related art; 
         FIG.  5    shows a structural schematic diagram of a valve clamping device according to a first example of a first embodiment of the present disclosure; 
         FIG.  6    shows a structural schematic diagram after combination of an adjusting portion and a supporting portion in  FIG.  5   ; 
         FIG.  7    shows a structural schematic diagram of a supporting portion in  FIG.  5   ; 
         FIG.  8    shows a structural schematic diagram of an adjusting portion in  FIG.  5   ; 
         FIG.  9   a    shows a structural schematic diagram of a tube body for preparing an adjusting portion in  FIG.  5    in an example; 
         FIG.  9   b    shows a structural schematic diagram of a frame structure of the tube body in  FIG.  9   a    after cutting and shaping; 
         FIG.  9   c    shows a structural schematic diagram of an example of an elastomer prepared by cutting; 
         FIG.  9   d    shows a structural schematic diagram of another example of an elastomer prepared by cutting; 
         FIG.  9   e    shows a partial schematic diagram of a proximal part of the elastomer in  FIG.  9     d;    
         FIG.  9   f    shows a structural schematic diagram of still another example of an elastomer prepared by cutting; 
         FIG.  10   a    shows a schematic diagram of an example of mesh structure of the adjusting portion in  FIG.  5   ; 
         FIG.  10   b    shows a schematic diagram of another example of mesh structure of the adjusting portion in  FIG.  5   ; 
         FIG.  11    shows a partial schematic diagram of an adjusting portion with an annular structure in an example of  FIG.  5   ; 
         FIG.  12    shows a structural schematic diagram after combination of a clamping portion and a driving portion in  FIG.  5   ; 
         FIG.  13    shows a structural schematic diagram of fit of the supporting portion and a base in  FIG.  5   ; 
         FIG.  14    shows a structural schematic diagram of fit of the valve clamping device in  FIG.  5    and a delivery device; 
         FIG.  15    shows a structural schematic diagram of fit of the supporting portion of the valve clamping device in  FIG.  5    and a delivery device; 
         FIG.  16    to  FIG.  20    show schematic diagrams of a delivery process of anterogradely approaching and repairing a mitral valve via a left atrium using the valve clamping device in  FIG.  5   ; 
         FIG.  21    shows a structural schematic diagram of a valve clamping device according to a second example of the first embodiment of the present disclosure; 
         FIG.  22    shows a structural schematic diagram of an adjusting portion in  FIG.  21   ; 
         FIG.  23    shows a partial schematic diagram of a distal end of the adjusting portion in  FIG.  22   ; 
         FIG.  24   a    shows a structural schematic diagram of a valve clamping device according to a third example of the first embodiment of the present disclosure; 
         FIG.  24   b    shows a structural schematic diagram of a preferred valve clamping device in  FIG.  24     a;    
         FIG.  25   a    shows a structural schematic diagram of a first curved surface side of an adjusting portion of a valve clamping device according to a fourth example of the first embodiment of the present disclosure; 
         FIG.  25   b    shows a structural schematic diagram of a second curved surface side of the adjusting portion in  FIG.  25     a;    
         FIG.  25   c    shows a top view of the adjusting portion in  FIG.  25     a;    
         FIG.  26   a    shows a structural schematic diagram of a valve clamping device according to a fifth example of the first embodiment of the present disclosure; 
         FIG.  26   b    shows a structural schematic diagram of a valve clamping device in  FIG.  26   a    partially received in a delivery device after radial compression; 
         FIG.  27    shows a structural schematic diagram of a valve clamping device in the related art; 
         FIG.  28    shows a schematic diagram of a state when the valve clamping device shown in  FIG.  27    clamps valve leaflets; 
         FIG.  29    shows a structural schematic diagram of a valve clamping device of a first example of a second embodiment of the present disclosure; 
         FIG.  30    shows a structural schematic diagram after combination of an adjusting portion and a supporting portion in  FIG.  29   ; 
         FIG.  31    shows a structural schematic diagram after combination of an adjusting portion and a fixing part in  FIG.  29   ; 
         FIG.  32   a    shows a schematic diagram of a three-dimensional structure of the adjusting portion in  FIG.  29    from a visual angle; 
         FIG.  32   b    shows a schematic diagram of a three-dimensional structure of the adjusting portion in  FIG.  29    from another visual angle; 
         FIG.  33    shows a schematic diagram of a state when the valve clamping device in  FIG.  29    clamps valve leaflets; 
         FIG.  34    shows a structural schematic diagram after combination of the clamping portion and a driving portion in  FIG.  29   ; 
         FIG.  35    shows a structural schematic diagram of the supporting portion in  FIG.  29   ; 
         FIG.  36    shows a structural schematic diagram of fit of the supporting portion and a base in  FIG.  29   ; 
         FIG.  37    shows a structural schematic diagram of fit of the supporting portion of the valve clamping device in  FIG.  29    and a delivery device; 
         FIG.  38    to  FIG.  42    show schematic diagrams of a process that the valve clamping device in  FIG.  29    approaches anterogradely via a left atrium and performs edge-to-edge repair on a mitral valve; 
         FIG.  43    shows a structural schematic diagram of a valve clamping device of a second example of a second embodiment of the present disclosure; 
         FIG.  44    shows a structural schematic diagram after combination of an adjusting portion and a supporting portion in  FIG.  43   ; 
         FIG.  45    shows a structural schematic diagram after combination of the adjusting portion and a fixing part in  FIG.  43   ; 
         FIG.  46    shows a schematic diagram of a state when a valve clamping device of a third example of the second embodiment of the present disclosure clamps valve leaflets; 
         FIG.  47    shows a structural schematic diagram of a valve clamping device of a fourth example of the second embodiment of the present disclosure; 
         FIG.  48    shows a structural schematic diagram after combination of a supporting portion, a driving portion and a clamping portion in  FIG.  47   ; 
         FIG.  49    shows a schematic diagram of a state when the valve clamping device in  FIG.  47    clamps valve leaflets; 
         FIG.  50    shows a structural schematic diagram of a valve clamping device of a fifth example of the second embodiment of the present disclosure; 
         FIG.  51    shows a structural schematic diagram of a valve clamping device of a sixth example of the second embodiment of the present disclosure; 
         FIG.  52    shows a structural schematic diagram after combination of a supporting portion, a driving portion and a clamping portion in  FIG.  51   ; 
         FIG.  53    shows a structural schematic diagram of a valve clamping device of a seventh example of the second embodiment of the present disclosure; 
         FIG.  54    shows a structural schematic diagram of fit of a valve clamping device of an eighth example of the second embodiment of the present disclosure and a delivery device; 
         FIG.  55    shows a schematic diagram of a state when the valve clamping device shown in  FIG.  54    approaches a mitral valve via a transapical route; 
         FIG.  56    shows a structural schematic diagram of an adaptive valve clamping device of a first example of a third embodiment of the present disclosure; 
         FIG.  57    shows a structural schematic diagram of the adaptive valve clamping device of a first example of a third embodiment of the present disclosure in an opened state; 
         FIG.  58    shows a structural schematic diagram of the adaptive valve clamping device of a first example of a third embodiment of the present disclosure in a closed state; 
         FIG.  59    shows a structural schematic diagram after combination of an adjusting portion and a supporting portion in  FIG.  57   ; 
         FIG.  60    shows a structural schematic diagram of the adjusting portion in  FIG.  57   ; 
         FIG.  61    to  FIG.  63    show different structural schematic diagrams of an adjusting portion of the first example of the third embodiment of the present disclosure; 
         FIG.  64    shows another structural schematic diagram of an adaptive valve clamping device of the first example of the third embodiment of the present disclosure; 
         FIG.  65    shows a structural schematic diagram of the supporting portion of the first example of the third embodiment of the present disclosure; 
         FIG.  66    shows a structural schematic diagram of a first seat body in  FIG.  65   ; 
         FIG.  67    shows a structural schematic diagram of a third seat body in  FIG.  65   ; 
         FIG.  68    shows a schematic diagram of a connection of a delivery device and the supporting portion of the first example of the third embodiment of the present disclosure; 
         FIG.  69    shows an enlarged schematic diagram of part I in  FIG.  68   ; 
         FIG.  70    to  FIG.  74    show schematic diagrams of a process that the adaptive valve clamping device in  FIG.  57    anterogradely approaches and repairs a mitral valve via a left atrium; 
         FIG.  75    and  FIG.  76    show structural schematic diagrams of a supporting portion and an adjusting portion of a second example of the third embodiment of the present disclosure; 
         FIG.  77    shows a structural schematic diagram of the supporting portion of the second example of the third embodiment of the present disclosure; 
         FIG.  78    shows another structural schematic diagram of the supporting portion and the adjusting portion of the second example of the third embodiment of the present disclosure; 
         FIG.  79    shows an exploded schematic diagram of an adjusting portion of a third example of the third embodiment of the present disclosure; and 
         FIG.  80    shows an exploded schematic diagram of a supporting portion of the third example of the third embodiment of the present disclosure. 
     
    
    
     DETAILED DESCRIPTION 
     The technical solutions of examples of the present disclosure are described below clearly and completely with reference to the drawings of the examples of the present disclosure. Obviously, the described examples are only part of examples of the present disclosure, rather than all of the examples. Based on the examples in the present disclosure, all other examples obtained by one skilled in the art without involving inventive work fall within the protection scope of the present disclosure. 
     In the description of the present disclosure, it is noted that an orientation or position relationship indicated by the terms “upper”, “lower”, “inner”, “outer”, and the like is based on an orientation or position relationship shown in the drawings, which is merely for convenience of describing the present disclosure and simplifying the description, rather than indicating or implying that the device or element referred to must have a particular orientation or be constructed and operated in a particular orientation, and thus should not be construed as limiting the disclosure. Moreover, the terms “first”, “second”, and the like are used for descriptive purposes only and should not be construed as indicating or implying relative importance. 
     In the description of the present disclosure, it is noted that in the field of interventional medical devices, a proximal end refers to an end close to an operator, and a distal end refers to an end far from the operator; an axial direction refers to a direction parallel to a line between the center of the distal end and the center of the proximal end of the medical device. The foregoing definitions are for convenience of description only and should not to be construed as limiting the present disclosure. 
     When an element is called “fixed to” or “provided on” another element, the element can be directly connected to another element or indirectly connected to another element through one or more connecting elements. When an element is called “connected” to another element, it can be directly connected to another element or connected to another element through one or more connecting elements. 
     It should be noted that in the field of interventional medical devices, a proximal end refers to an end close to an operator, and a distal end refers to an end far from the operator; an axial direction refers to a direction of the central axis of rotation of objects such as columns and tubes; a circumferential direction refers to a direction surrounding the axis of the objects such as columns and tubes (perpendicular to the axis and perpendicular to the cross-sectional radius); and a radial direction refers to a direction along the diameter or radius. It should be noted that “end” in terms of “proximal end”, “distal end”, “one end”, “another end”, “first end”, “second end”, “initial end”, “terminal end”, “both ends”, “free end”, “upper end” and “lower end” is not limited to an end tip, end point or end face, but also comprises a part extending a certain axial distance and/or radial distance from the end tip, end point, or end face on an element to which the end tip, end point, or end face belongs. The above definition is only for convenience of expression and cannot be construed as a limitation of the present disclosure. 
     The valve clamping device shown in the drawings of the specification comprises: supporting portions A 110 , B 110  and C 110  provided along the axial direction; hollow adjusting portions A 120 , B 120  and C 120 , at least part of which are provided in the adjusting portions A 120 , B 120  and C 120 , an end of which is sleeved outside the supporting portions A 110 , B 110  and C 110 , and the other end of which is movable with respect to the supporting portions A 110 , B 110  and C 110 ; clamping portions A 130 , B 130  and C 130  surrounding the outside of the adjusting portions A 120 , B 120  and C 120 ; and driving portions A 140 , B 140  and C 140  connected to the clamping portions to drive the clamping portions A 130 , B 130  and C 130  to be close to or away from the adjusting portions A 120 , B 120  and C 120 . 
     In the valve clamping device provided in the present disclosure, the supporting portions A 110 , B 110  and C 110  comprise first seat bodies A 112 , B 115  and C 112  and second seat bodies A 111 , B 111  and C 114  which are connected along the axial direction. The first seat bodies A 112 , B 115  and C 112  are provided in the adjusting portions A 120 , B 120  and C 120 , that is, at least part of the first seat bodies A 112 , B 115  and C 112  is provided in the adjusting portions A 120 , B 120  and C 120 ; and the adjusting portions A 120 , B 120  and C 120  comprise first ends A 121   a , B 121  and C 122  and second ends A 121   b , B 123  and C 124  provided opposite in the axial direction, and self-expanding bodies A 120 , B 125  and C 121  located between the first ends A 121   a , B 121 , C 122  and the second ends A 121   b , B 123  and C 124 . The first seat bodies A 112 , B 115  and C 112  are further away from the clamping portions A 130 , B 130  and C 130  than the second seat bodies A 111 , B 111  and C 114 . 
     In some embodiments, the first end A 121   a  is fixedly sleeved outside the second seat body A 111 , and the second end A 121   b  hangs freely with respect to the supporting portion A 110  to be movable with respect to the supporting portion. The second end A 121   b  can also be movably sleeved outside the first seat body A 112  and can move axially with respect to the supporting portion A 110 . 
     In some embodiments, the second end B 123  is fixedly sleeved outside the first seat body B 115 . At this time, only a part of the first seat body B 115  is in the adjusting portion B 120 , and the first end B 121  is movably sleeved outside the second seat body B 111  and can move along the axial direction with respect to the supporting portion B 110 . 
     In some embodiments, the first end C 122  is movably sleeved outside the second seat body C 114  and can move in the axial direction with respect to the supporting portion A 110 , and the second end C 124  is sleeved outside the first seat body C 112  and can move in the axial direction with respect to the supporting portion C 110 . The second end C 124  can also hang freely with respect to the supporting portion C 110  to be movable with respect to the supporting portion C 110 . 
     In some embodiments, the self-expanding bodies A 120 , B 125  and C 121  are elastomers, and the adjusting portions A 120 , B 120  and C 120  are provided with openings at the second ends A 121   b , B 123  and C 124 . 
     In some embodiments, the elastomer is of at least one type selected from the group consisting of a mesh structure, a frame structure, a dense structure or a porous structure. 
     In some embodiments, the elastomer is of a mesh structure or a frame structure, and at least a part of an outer surface and/or at least a part of an inner surface of the elastomer are covered with a biocompatible film. 
     In some embodiments, the second ends A 121   b , B 123  and C 124  of the adjusting portions A 120 , B 120  and C 120  are heads with a central through hole, a part of the elastomers penetrates and is fixed in the head, and the central through hole forms an opening; or edges of the second ends A 121   b , B 123  and C 124  are sleeved with a hollow sleeve structure to form an opening; or the edges of the second ends A 121   b , B 123  and C 124  are enclosed to form an opening. 
     In some embodiments, the elastomer is of a mesh structure, the elastomer is woven from a shape memory material, and a mesh wire woven to form the mesh structure is bent back at the second ends A 121   b , B 123  and C 124  to form the openings. 
     In some embodiments, the elastomer is of a frame structure, the frame structure is cut from a shape memory material, the frame structure comprises a plurality of supporting rods, the adjacent supporting rods are spaced apart from or cross-linked with each other, and proximal ends of a plurality of the supporting rods converge to form an opening. 
     In some embodiments, the elastomer is of a dense structure made of silica gel; or the elastomer is of a porous structure made of sponge; and a second end edge of the dense structure or the porous structure forms an opening. 
     In some embodiments, a diameter of at least a part of the self-expanding body in a natural state gradually increases from a first end of the adjusting portion to a second end of the adjusting portion. 
     In some embodiments, the self-expanding bodies A 120 , B 125  and C 121  have a recessed area connected to the second end, the recessed area is recessed toward the first end, and the second end is located between two end faces of the self-expanding bodies A 120 , B 125  and C 121  along an axis. 
     In some embodiments, the self-expanding bodies A 120 , B 125  and C 121  comprises a first section, a second section and a third section successively connected; the first section extends from the second ends A 121   b , B 123  and C 124  of the adjusting portions A 120 , B 120  and C 120  toward a second end of the supporting portion, and the first section surrounds the outside of the second end of the supporting portion; the second section continues to extend radially outward from the first section; and the third section extends radially inward from the second section toward a first end of the supporting portion to the first ends A 121   a , B 121  and C 122  of the adjusting portion. 
     In some embodiments, the self-expanding bodies A 120 , B 125  and C 121  also comprise a bending section which is connected between the second ends A 121   b , B 123  and C 124  of the adjusting portions A 120 , B 125  and C 121  and the first section. 
     In some embodiments, a radial dimension of the second section of the self-expanding bodies A 120 , B 125  and C 121  ranges from 4 mm to 15 mm, and a radial dimension of the first ends A 121   a , B 121  and C 122  of the adjusting portions A 120 , B 125  and C 121  ranges from 1 mm to 5 mm. 
     In some embodiments, the self-expanding bodies A 120 , B 125  and C 121  comprises a plurality of first curved surfaces and a plurality of second curved surfaces along a circumferential direction, and the first curved surface and the second curved surface are adjacent to each other. The two oppositely disposed first curved surfaces face the clamping portions respectively, and the area of the second curved surface is less than the area of the first curved surface. 
     In some embodiments, the first seat bodies A 112 , B 115  and C 112  comprise an interface end connected to the second seat bodies A 111 , B 111  and C 114  and a free end provided opposite to the interface end. The free end is located in the adjusting portions A 120 , B 120  and C 120 . 
     In some embodiments, the self-expanding bodies A 120 , B 125  and C 121  are elastomers, and the adjusting portions A 120 , B 120  and C 120  are provided with openings at the second ends A 121   b , B 123  and C 124 ; and the size of the opening is less than or equal to the size of the free end. 
     In some embodiments, a hollow sleeve structure is sleeved outside an edge of one end of the adjusting portions A 120 , B 120  and C 120 , and the sleeve structure is sleeved outside the supporting portion. 
     In some embodiments, the clamping portions A 130 , B 130  and C 130  comprise at least two clamp arms, the at least two clamp arms are symmetrically provided with respect to the adjusting portions A 120 , B 120  and C 120 . The driving portions A 140 , B 140  and C 140  are connected to the clamp arms respectively to drive each of the clamp arms to be close to or away from the adjusting portions A 120 , B 120  and C 120 . 
     In some embodiments, the supporting portions A 110 , B 110  and C 110  further comprises a base connected to the second seat body, each of the clamp arms is rotationally connected to the base, and there is axial spacing between the first end and a connecting position of the clamp arm and the base. 
     In some embodiments, the driving portions A 140 , B 140  and C 140  comprise: a driving shaft, a connecting seat and at least two connecting rods; wherein one end of each of the connecting rods is connected to the clamping portion, and the other end of each of the connecting rods is pivotally connected to the connecting seat; and one end of the driving shaft is connected to the connecting base, and the other end of the driving shaft movably penetrates in the base. 
     In some embodiments, the valve clamping device further comprises a locking portion provided in the base, which restricts relative movement of the driving shaft and the base. 
     In some embodiments, the driving portions A 140 , B 140  and C 140  comprise: a driving shaft, an automatic closing unit and at least two connecting rods; the driving shaft movably penetrates in the supporting portion, one end of each of the connecting rods is rotationally connected to one of the clamp arms, and the other end of each of the connecting rods is rotationally connected to the driving shaft; and the automatic closing unit is connected to the clamp arm to cause the clamp arm to abut against the adjusting portion in a natural state. 
     In some embodiments, the driving portions A 140 , B 140  and C 140  comprise: a driving shaft and at least two elastic driving arms. One end of the driving shaft movably penetrates in the supporting portion, one end of each of the elastic driving arms is fixedly connected to the other end of the driving shaft, and the other end of each of the elastic driving arms is connected to one of the clamp arms; and the elastic driving arms are configured to cause the clamp arm to abut against the adjusting portion in a natural state. 
     In some embodiments, a terminal end of the clamp arm is provided with a flanging section which is a cambered surface overturned toward the outside of the terminal end of the clamp arm, and the self-expanding body protrudes from the flanging section in the axial direction after the clamp arm abuts against the adjusting portion. 
     In some embodiments, the self-expanding bodies A 120 , B 125  and C 121  are provided with an adaptation section corresponding to the flanging section, and a shape of the adaptation section toward the flanging section is complementary to the cambered surface. 
     In some embodiments, the valve clamping device also comprises gripping portions A 150 , B 150  and C 150 . The gripping portion is provided between the clamping portion and the adjusting portion and is able to be close to or away from the adjusting portion. When the gripping portion and the clamping portion are away from the adjusting portion, the gripping portion is at least partially accommodated in an inner surface of the clamping portion. 
     First Embodiment 
     Referring to  FIG.  5    to  FIG.  20   , a valve clamping device A 100  according to the first embodiment of the present disclosure comprises: a supporting portion A 110  comprising a connecting end A 111  and a free end A 112  disposed oppositely; a hollow adjusting portion A 120 , at least a part of the supporting portion A 110  is disposed in the adjusting portion A 120 , one end A 121   a  of the adjusting portion A 120  is sleeved outside the connecting end A 111  and connected to the supporting portion A 110 , and the other end A 121   b  of the adjusting portion A 120  hangs freely; a clamping portion A 130  which is disposed around the outside of the adjusting portion A 120 ; and a driving portion A 140  which is connected to the clamping portion A 130  to drive the clamping portion A 130  to open or close around the adjusting portion A 120 . 
     For the valve clamping device A 100 , at least a part of the supporting portion A 110  is provided in a hollow of the adjusting portion A 120 . One end A 121   a  of the adjusting portion A 120  is sleeved outside the connecting end A 111  and connected to the supporting portion A 110 , and the other end A 121   b  of the adjusting portion A 120  hangs freely. The freely hanging end is no longer limited by the supporting portion A 110  or the delivery device A 200 , which improves an axial deformation ability of the adjusting portion A 120  enhances a bending deformation ability thereof along the axial direction. Therefore, when radially compressed into the delivery device for in vivo transportation, the valve clamping device A 100  is not only easy to be compressed into the sheath, but also can adapt to blood vessels of different bending curvature when transported in blood vessels, so as to facilitate passage of the delivery device in blood vessels, thus reducing damage to vessel walls. In addition, after the valve clamping device A 100  is implanted, in a process of clamping the valve leaflet and the adjusting portion A 120  with the clamp arm A 131 , since axial deformation of the adjusting portion A 120  is not limited, elastic fit between the valve leaflet and the adjusting portion A 120  can be improved, and thus adaptability to physiological structures of valve leaves in different patients can be improved. 
     Referring to  FIG.  6    and  FIG.  7   , the supporting portion A 110  may be a circular tube body with both ends axially penetrated. The distal end of the circular tube body is the connecting end A 111 , and the proximal end is the free end A 112 . At least part of the supporting portion A 110  is provided in the hollow of the adjusting portion A 120 . For example, the free end A 112  of the supporting portion A 110  is located in the adjusting portion A 120 , and the free end A 112  is located in the adjusting portion A 120  in both a delivery state and an open state, and will not be exposed from the adjusting portion A 120 . The supporting portion A 110  is further provided with a penetrating channel A 113  in an axial through hole shape to mate with the driving portion A 140  and the delivery device A 200 . At least two locking positions A 114  are provided on the tube wall of the circular tube body of the supporting portion A 110  for detachable connection with the delivery device A 200 . For example, after a locking nose A 221  (refer to  FIG.  14   ) on the delivery device A 200  snaps into the locking position A 114 , the delivery device A 200  is snap connected to the supporting portion A 110  to deliver the valve clamping device A 100 . When the locking nose A 221  is separated from the locking position A 114 , the delivery device A 200  is separated from the valve clamping device A 100 , and the valve clamping device A 100  is released in the body. It should be noted that the structure of the supporting portion A 110  here is only used as an example and does not limit the present disclosure. Based on teachings of the present disclosure, other structures of the supporting portion A 110  adopted are within the protection scope of the present disclosure. 
     The free end A 112  at the proximal end of the valve clamping device A 100  of the present disclosure is located in the hollow adjusting portion A 120  whether in the delivery state or in the released and open state. Therefore, the free end A 112  will not be exposed in the delivery device A 200  or in the heart, so as to avoid scouring of blood and minimize thrombosis after implantation. Moreover, after implantation, direct contact with the valve leaflet is avoided, and with long-term pulsation of the valve leaflet, wear and even perforation of the valve leaflet is avoided, and safety of implanting into patients is improved. 
     Referring to  FIG.  6    and  FIG.  8   , the adjusting portion A 120  comprises a deformable elastomer A 123  with a hollow accommodation cavity, and at least part of the supporting portion A 110  is provided in the hollow accommodation cavity. One end A 121   a  of the elastomer A 123  is connected to the supporting portion A 110 , and the other end A 121   b  of the elastomer A 123  has an opening A 122  and hangs freely. The elastomer A 123  can be deformed, so as to adapt to spacing between different valve leaflets and adjust pulling degree of the valve leaflets by the valve clamping device A 100 . The opening A 122  of the elastomer A 123  is configured to thread the distal end of the delivery device A 200 . It should be noted that the distal end of the delivery device A 200  is connected to the proximal end (free end) of the supporting portion A 110  after penetrating into the inner cavity of the elastomer A 123  via the opening A 122 , while the opening A 122  at the distal end of the elastomer A 123  is not connected to the distal end of the delivery device A 200  or the proximal end (free end) of the supporting portion A 110 , that is, the proximal end A 121   b  of the elastomer A 123  is in a freely hanging state. Thus, in the process of delivery or clamping the valve leaflets, when the clamping portion A 130  is closed, the elastomer A 123  in the adjusting portion A 120  is not limited by the supporting portion A 110  or the delivery device A 200  and can be deformed in the radial and axial directions. A large deformation degree is more conducive to delivery and has a stronger adaptability to the valve leaflets; when the connection between the distal end of the delivery device A 200  and the proximal end (free end) of the supporting portion A 110  is released, the freely hanging end of the adjusting portion A 120  has stronger deformability and stronger adaptability to the valve leaflets. 
     In one example, the elastomer A 123  is of a mesh structure, which can be woven from a shape memory material. For example, a super elastic nickel titanium alloy material can be woven and subjected to heat setting treatment to form a compressed state and an opened state. The compressed state is maintained in the delivery device A 200  and the opened state is maintained after release in the body. In one example, the elastomer A 123  of the mesh structure is formed by weaving. During manufacture, 12 to 36 nickel titanium wires with a diameter of 0.02 mm to 0.15 mm are wound on a lining rod to form a tubular woven mesh with oppositely provided proximal and distal ends. At the proximal end, a plurality of mesh wires A 124  are bent back to form a plurality of rings which are enclosed to form the proximal edge. A metal wire is then passed through all rings at the proximal end in turn, and then the metal wire is tightened moderately, but an opening with a moderate size is reserved. Then, a setting mold is inserted from the distal end of the self-woven mesh, and the nickel titanium wire at the distal end is wound into a bundle by a metal wire afterwards; the woven mesh and setting mold are put into an electric heating circulating air box furnace and a heat setting treatment is conducted at 450° C. to 650° C. (preferably 500° C.) for 10 to 20 minutes; after cooling to room temperature, the metal wires at the proximal and distal ends are removed, the setting mold is taken out, and all nickel titanium wires at the distal end are inserted into the head made of stainless steel for crimping or welding to obtain the elastomer A 123  of a mesh structure. 
     Referring to  FIGS.  9   a  and  9   b   , the elastomer A 123  can also be of a frame structure, which is cut from hard metal or polymer materials such as stainless steel, alloy and polyvinyl chloride. An inner surface of the cut elastomer A 123  is smooth and flat to avoid thrombosis in the elastomer A 123  and ensure that the fixing part A 220  (refer to  FIG.  14   ) can be smoothly withdrawn from the opening A 122  of the elastomer A 123 . The cutting method can be wire cutting or laser cutting, preferably laser cutting. During manufacture, a nickel titanium tube A 126  is first cut into a required shape with a laser cutting machine. The cut nickel titanium part is pressed into the setting mold with a certain shape. Then the nickel titanium part and the setting mold are put into the electric heating circulating air box furnace for a setting heat treatment at 450° C. to 650° C. (preferably 500° C.) for 10 to 20 minutes; after taking out and cooling to room temperature, the setting mold is removed to obtain the set elastomer A 123 , which is of a frame structure including a plurality of radially spaced and axially extended supporting rods A 127 , and proximal ends of a plurality of the supporting rods A 127  converge to form a freely hanging proximal edge. Distal ends of a plurality of the supporting rods A 127  converge and are welded onto the supporting portion A 110 . The nickel titanium tube is a pipe with certain wall thickness, and specifically, the wall thickness of the nickel titanium tube is less than 1 mm, preferably 0.02 mm to 0.15 mm, and the nickel titanium tube has certain flexibility and rigidity. 
     Referring to  FIG.  9   c   , the elastomer A 123  is of a frame structure formed by cutting, which is formed by fittingly connecting a plurality of the supporting rods A 127 . The proximal end A 121   b  of the elastomer A 123  is an opening structure, and the proximal edges of all supporting rods A 127  at the proximal end A 121   b  of the frame structure are enclosed to form the above opening A 122 . 
     Referring to  FIGS.  9   d  and  9   e   , the elastomer A 123  is still of a frame structure, which is formed by fittingly connecting a plurality of the supporting rods A 127 . The proximal end A 121   b  of the elastomer A 123  is an open structure. Each of the supporting rods A 127  at the proximal end A 121   b  may also be provided with a through hole A 127   a . The through holes A 127   a  are connected in series through a flexible wire A 129  to form an opening A 122 . 
     Referring to  FIG.  9   f   , the elastomer A 123  is still of a frame structure, which is formed by fittingly connecting a plurality of supporting rods A 127 . The proximal end A 121   b  of the elastomer A 123  is an opening structure. The adjacent supporting rods A 127  of the frame structure can be cut and then cross-linked with each other. For example, the adjacent supporting rods A 127  at the edge of the proximal end A 121   b  are cut and cross-linked with each other to form a ring structure A 129 . 
     Certainly, the elastomer A 123  of the adjusting portion A 120  may be other elastic hollow structures. For example, the elastomer A 123  may be of a dense structure or a porous structure, the dense structure is silicone colloid, the porous structure is sponge, and the proximal edge of the dense structure or porous structure forms an opening A 122  for the distal end of the delivery device A 200  to penetrate into the inner cavity of the elastomer A 123 . 
     The shape of the elastomer A 123  is at least one selected from the group consisting of a cylindrical shape, a conical shape, a spherical shape, a spheroidal shape, an ellipsoidal shape, a fan spherical shape and a gourd shape, or a combination of multiple shapes. In order to prevent the elastomer A 123  from affecting relative opening and closing between the gripping arm A 151  or the clamp arm A 131  and the supporting portion A 110  and to prevent a clamping effect on the valve leaflets, a diameter of a part of the elastomer A 123  near the distal end should be smaller than that of other parts of the elastomer A 123 . For example, in the implementation mode shown in  FIG.  8   , the middle of the elastomer A 123  is cylindrical, the two ends are cones, and cone angles of the cones at the two ends are the same. It should be noted that in other examples, the elastomer A 123  can also be of any other shape, as long as the diameter of the distal end does not affect the clamping effect, for example, a spindle structure with the same cone angle at both ends shown in  FIG.  10   a    or a structure with different cone angles at both ends shown in  FIG.  10     b.    
     The adjusting portion A 120  comprises a proximal end and a distal end. In one example, a hollow sleeve structure (not shown in the figure) is sleeved on the proximal edge of the elastomer A 123  to form an opening. The sleeve structure can be an existing head structure. The sleeve structure can be annular or polygonal, and can be made of hard materials such as stainless steel, so that the mesh wire of the mesh structure or the supporting rod of the frame structure can properly converge to the central axis but is not closed, so as to form an opening A 122  at the center of the sleeve structure. In another example, the proximal edge of the elastomer A 123  is enclosed to form the opening A 122 , and the size of the opening A 122  is less than or equal to the size of the free end A 112 , so as to ensure that the free end A 112  of the supporting portion A 110  will not extend from the adjusting portion A 120  in the compressed state and the opening state. 
     There are many ways for the proximal edge of the elastomer A 123  to be enclosed to form the opening A 122 . In a specific implementation mode of the present example, the mesh structure A 123  is made of nickel titanium alloy wire through weaving and heat setting treatment, and the mesh wire A 124  of the mesh structure A 123  is bent back at the proximal end to form the proximal edge, that is, the bent parts of all the mesh wire A 124  at the proximal edge are enclosed to form the opening A 122 . The bent shape can be set as required, for example, bending back after bending once or bending for many times to form at least one ring, which is not described here one by one. 
     The proximal edge of the elastomer A 123  is enclosed to form an opening A 122 , and the proximal head of the adjusting portion A 120  of the valve clamping device A 100  is canceled. When the clamping portion A 130  is closed, the elastomer A 123  can be deformed in the radial direction and the axial direction, and the deformation degree is large, which is more conducive to delivery; the elastomer A 123  is free of the axial movement limitation imposed by the head on each mesh wire or supporting rod thereof, so the elastomer A 123  can be curled or bent moderately, so as to adequately fit the valve leaflet and better adapt to the physiological structure of the valve leaflets in different patients; the risk of falling off of the proximal head part in the related art after implantation for a period of time can be avoided; and the distal end of the elastomer A 123  is connected to the supporting portion A 110 , while the opening A 122  at the proximal end is open. Therefore, the center of gravity is always located in the axial direction of the supporting portion A 110  (i.e. the axial line of the elastomer A 123 ). Therefore, the elastomer A 123  has good self-centrality and is not easy to tilt. 
     Further, referring to  FIG.  11   , the adjusting portion A 120  can also comprise an annular structure A 125  provided at the proximal edge to stabilize the shape of the opening A 122 . All the mesh wires A 124  located at the proximal end of the mesh structure A 123  are wound and connected to the annular structure A 125 . The annular structure A 125  is made of a flexible or elastic material, and a wire diameter thereof is larger than a wire diameter of the mesh wire of the woven mesh structure A 123 , so as to provide a certain supporting force for the opening A 122  of the mesh structure A 123 , but does not affect the axial deformability and bendability of the mesh structure A 123 . 
     The distal end of the adjusting portion A 120  is fixedly connected to the supporting portion A 110 . Specifically, a hollow sleeve structure is sleeved outside the distal edge of the elastomer A 123 , and the sleeve structure is fixedly sleeved on the supporting portion A 110 . The sleeve structure of the distal end A 121   a  (for example, the head at the distal end A 121   a  in  FIG.  8   ) and the supporting portion A 110  are fixed together by common detachable or non-detachable connection methods such as welding, bonding, threaded connection, crimping, and bolt locking, for example, welding connection may be preferred. 
     Referring to  FIGS.  12  and  13   , the clamping portion A 130  comprises at least two clamp arms A 131 , and generally may comprise at least one group of clamp arms A 131 . Each group of the clamp arms A 131  comprises two clamp arms A 131  symmetrically provided with respect to the adjusting portion A 120 . The clamping portion A 130  in the figures comprises a group of the clamp arms A 131 . It should be noted that this is only an example, one skilled in the art can select the appropriate number of the clamp arms A 131  as needed, for example, two or more groups of clamp arms. The driving portion A 140  is connected to each of the clamp arms A 131 . For example, the driving portion A 140  is respectively connected to two clamp arms A 131  in one group of the clamp arms A 131  to drive each of the clamp arms A 131  to rotate around the adjusting portion A 120 . It should be noted that three or more clamp arms A 131  can also be set in each group as needed. For example, three valve leaflets of a tricuspid valve can be clamped by three clamp arms A 131  that can be opened and closed relatively, so as to treat tricuspid regurgitation. 
     In the delivering state, the driving portion A 140  drives the clamp arm A 131  to close around the adjusting portion A 120 , so as to reduce the outer diameter of the valve clamping device A 100  and facilitate delivering; and after the valve clamping device A 100  opens in the body, the driving portion A 140  drives the clamp arm A 131  to clamp the valve leaflet between the clamp arm A 131  and the adjusting portion A 120  to realize valve clamping. 
     In a preferred implementation mode of this example, the valve clamping device A 100  also comprises a gripping portion, which may generally comprise at least one group of the gripping arms A 151 , and each group of the gripping arms A 151  comprises two gripping arms A 151  symmetrically provided with respect to the adjusting portion A 120 . The gripping portion (e.g. gripping arm A 151 ) is provided between the clamping portion A 130  (e.g. clamp arm A 131 ) and the adjusting portion A 120  and may be opened or closed with respect to the adjusting portion A 120 . When both the gripping portion and the clamping portion A 130  open, the gripping portion is at least partially accommodated in the inner surface of the clamping portion A 130 . Certainly, three or more gripping arms A 151  may also be set in each group as required, so as to mate with the clamp arm A 131  to realize the clamping function. 
     In the delivering state, the gripping portion is at least partially accommodated in the inner surface of the clamping portion A 130 , that is, the gripping arm A 151  is at least partially accommodated in the inner surface of the clamp arm A 131 , so as to reduce the outer diameter of the valve clamping device A 100  to facilitate delivering; and after the clamp arm A 131  and the gripping arm A 151  mate to clamp the valve leaflet, the recessed inner surface may increase the contact area between the clamp arm A 131  and the valve leaflet, and cause the gripping arm A 151  to press the valve leaflet into the inner surface of the clamp arm A 131  to increase the clamping force on the valve leaflet. 
     Still referring to  FIGS.  12  and  13   , the valve clamping device A 100  also comprises a base A 160  fixedly connected to the supporting portion A 110 , and the clamping portion A 130  is rotationally connected to the base A 160 . Specifically, the proximal end of the base A 160  is fixedly connected to the distal end A 121   a  of the supporting portion A 110 . It should be noted that this part is defined as the term “base” for the convenience of description. A structure to realize the function of the base A 160  may also be the distal end of the supporting portion A 110 , that is, an integrated structure formed with the supporting portion A 110 . Therefore, the definition of the term “base” should not limit the scope of the present disclosure. The clamp arms A 131  in each group are connected through a pivot A 132  on the base A 160 , so that under the drive of the driving portion A 140 , the clamp arms A 131  cooperate with each other and may be opened and closed around the adjusting portion A 120  together. 
     Still referring to  FIG.  12    and  FIG.  13   , the driving portion A 140  comprises a driving shaft A 141 , a connecting seat A 142  and two connecting rods A 143 ; wherein one end of each of the connecting rods A 143  is connected to the clamping portion A 130 , and the other end is pivotally connected to the connecting seat A 142 ; one end of the driving shaft A 141  is connected to the connecting seat A 142 , and the other end movably penetrates in the base A 160 . Specifically, one end of each of the connecting rods A 143  is connected to one clamp arm A 131 , and the other end is connected to the connecting seat A 142  through a pivot A 144 , that is, each of the clamp arms A 131  is rotationally connected to the distal end of the connecting seat A 142  of the driving shaft A 141  through the connecting rod A 143  on the corresponding side. The driving shaft A 141  movably passes through the base A 160 . When the driving shaft A 141  slides axially with respect to the base A 160 , the connecting rod A 143  rotates and drives the clamp arm A 131  to open and close with respect to the base A 160 . 
     Specifically, the driving portion A 140  comprises at least one group of connecting rods A 143 . The number setting of the connecting rods A 143  corresponds to the clamp arms A 131  one to one. For example, two clamp arms A 131  are used in the figure, and two cooperating connecting rods A 143  are provided correspondingly. The distal end of the connecting rod A 143  is rotationally connected to the connecting seat A 142  at the distal end of the driving shaft A 141  by a rotating pin or bolt A 144  and the like. When the driving shaft A 141  axially slides toward the distal end with respect to the base A 160 , the connecting rod A 143  is driven to move. Under the pull of the connecting rod A 143 , the clamp arm A 131  rotates around a pin hole A 144  and opens with respect to the base A 160 . When the driving shaft A 141  slides axially toward the proximal end with respect to the base A 160 , the connecting rod A 143  pulls the clamp arm A 131  to rotate around the pin hole A 144  and close with respect to the base A 160 . 
     The connecting seat A 142  is fixedly provided at the distal end of the driving shaft A 141  by means such as welding, and the connecting seat A 142  is provided with a pair of pins. The pin hole is used to hinge the connecting rod A 143  through the pin A 144 , and the other end of the connecting rod A 143  is connected to the clamp arm A 131 , so as to realize the opening and closing of the clamp arm A 131  with respect to the base A 160 . The shape of the connecting seat A 142  is any structure such as a hemisphere, a spherical crown or a warhead shape, so that the valve clamping device A 100  is pushed more easily in the body. The driving shaft A 141  and the connecting seat A 142  may be integrated or non-integrated. In order to ensure safety after implantation, the driving shaft A 141  and the connecting seat A 142  are made of biocompatible materials such as polyester, silicone, stainless steel, cobalt alloy, cobalt chromium alloy and titanium alloy, preferably stainless steel or cobalt chromium alloy with high hardness. 
     Preferably, as shown in  FIG.  12   , the valve clamping device A 100  also comprises a locking portion A 170  provided in the base A 160 , which restricts the relative movement of the driving shaft A 141  and the base A 160 . In the delivering state, the locking portion A 170  restricts the relative movement of the driving shaft A 141  and the base A 160 , so as to ensure that the clamping portion A 130  is always closed with respect to the adjusting portion A 120  and the supporting portion A 110  and to avoid accidental opening of the clamping portion A 130 ; and after the valve clamping device A 100  reaches the vicinity of the mitral valve, the restriction of the locking portion A 170  on the driving shaft A 141  is unlocked, and the clamping portion A 130  can be driven by the driving portion A 140  to open with respect to the adjusting portion A 120  and the supporting portion A 110  and support the valve leaflet. Any suitable locking portion in the related art can be used, which is not described here. 
     Referring to  FIG.  14    and  FIG.  15   , the valve clamping system of the present example comprises the valve clamping device A 100  and a delivery device A 200 . The delivery device A 200  comprises a pushing shaft A 210  with a certain axial length and a mandrel (not shown in the figure) movably penetrating the pushing shaft A 210 . The pushing shaft A 210  is detachably connected to the supporting portion A 110 , and the mandrel is connected to the driving portion A 140  to drive the clamping portion A 130  to open and close with respect to the supporting portion A 110 . In the present example, the proximal end of the driving shaft A 141  is provided with an external thread, and the mandrel is threaded with the driving shaft A 141 , so as to control the axial movement of the driving shaft A 141  through the mandrel outside the patient. It should be noted that only part of the structure of the delivery device is described here, and any suitable structure in the related art can be adopted for other parts, which is be described here. 
     Specifically, the proximal outer wall of the supporting portion A 110  is symmetrically provided with at least one locking position A 114  connected to the cavity of the supporting portion A 110 . The distal end of the pushing shaft A 210  is provided with a fixing part A 220  comprising two branches, and the terminal end of each branch is a protruded locking nose A 221 . In the natural state, the two branches point to the central axis of the fixing part A 220 . During assembly, the fixing part A 220  is inserted into the supporting portion A 110 , and the mandrel of the delivery device A 200  is inserted into the pushing shaft A 210  until the mandrel is inserted into the fixing part A 220 , and the two branches of the fixing part A 220  are pushed up outward. The locking nose A 221  at the terminal end of the branch is locked into the two locking positions A 114  of the supporting portion A 110 , so as to connect the supporting portion A 110  to the fixing part A 220 , that is, to connect the valve clamping device A 100  to the delivery device A 200 . When the mandrel is withdrawn from the fixing part A 220  and the pushing shaft A 210 , the two branches restore the inward natural state. The locking nose A 221  is separated from the locking position A 114  of the supporting portion A 110 , so that the connection between the valve clamping device A 100  and the delivery device A 200  is released. The fixing part A 220  is made of materials with certain hardness and elasticity such as nickel and titanium. The pushing shaft A 210  may be a multi-layer pipe. The mandrel is made of stainless steel. 
     The interior of the supporting portion A 110  is provided with a through hole as the penetrating channel A 113  of the driving shaft A 141 , and the driving shaft A 141  slidingly penetrates the penetrating channel A 113  of the supporting portion A 110  along the axial direction. The proximal end of the driving shaft A 141  is provided with an external thread for connection with the mandrel of the delivery device A 200 , so as to control the axial movement of the driving shaft A 141  through the mandrel. After the clamping portion A 130  and the gripping portion A 150  cooperate and clamp the valve tissue, the mandrel drives the driving shaft A 141  to move toward the proximal end in the axial direction, and the driving shaft A 141  drives the connecting rod A 143  to rotate. The connecting rod A 143  drives the clamp arm A 131  to close with respect to the supporting portion A 110  until the clamp arm A 131  is completely closed with respect to the supporting portion A 110 , so that the valve clamping device A 100  is in the folded and closed state and falls below the valve. After that, the connection between the mandrel and the driving shaft A 141  may be released, the mandrel is withdrawn from the fixing part A 220 , and the locking nose A 221  is separated from the locking position A 114  of the supporting portion A 110 , so as to release the valve clamping device A 100  from the delivery device A 200 . In the process of release, since the connecting position (i.e., disengagement position) between the valve clamping device A 100  and the delivery device A 200  is located in the adjusting portion A 120  of the valve clamping device A 100 , and the proximal end of the adjusting portion A 120  is provided with an open opening A 122 , no part will hook the locking nose A 221  at the terminal end of the branch of the fixing part A 220 , which facilitates the release of the valve clamping device A 100 . In addition, the release position is provided inside the adjusting portion A 120  and is not directly scoured by blood, which can avoid failure of the mechanism at the release position and reduce the risk of thrombosis. 
     Referring to  FIG.  16    to  FIG.  20   , a use process of the valve clamping device A 100  of the present disclosure is described, taking anterograde approach and repair of the mitral valve via the left atrium as an example. 
     Step 1: pushing the driving shaft A 141  and the valve clamping device A 100  connected thereto from the left atrium A 2  to the left ventricle A 3  via the mitral valve A 1  with a guiding device (not shown in the figure) such as a bendable sheath, as shown in  FIG.  16   ; 
     Step 2: adjusting the valve clamping device A 100  to approach the anterior leaflet Ala and the posterior leaflet Alb of the mitral valve A 1 ; 
     Step 3: unlocking a locking portion in the base A 160 , pulling the mandrel and the driving shaft A 141  to the proximal end, driving the clamp arm A 131  to open with respect to the supporting portion A 110 , and adjusting the direction of the clamp arm A 131 , at which time a relative position between the clamp arm A 131  and the anterior and posterior leaflets Ala, Alb of the mitral valve A 1  can be observed by an X-ray device, and the clamp arm A 131  is made perpendicular to a coapting line of the mitral valve A 1 , as shown in  FIG.  17   ; 
     Step 4: withdrawing the entire valve clamping device A 100  to the proximal end to let the clamp arm A 131  hold the valve leaflet A 1  on the left ventricle A 3  side, and releasing the gripping arms A 151  on both sides, wherein the gripping arm A 151  on each side presses the valve leaflet A 1  on the atrium side and cooperates with the clamp arm A 131  on the side to fix the valve leaflet A 1 , realizing complete clamping of the valve leaflet A 1 , as shown in  FIG.  18   ; 
     Step 5: pushing the mandrel and the driving shaft A 141  to the distal end when the anterior mitral leaflet Ala and the posterior mitral leaflet Alb of the mitral valve A 1  are clamped between the pair of clamp arms A 131  and the gripping arms A 151  respectively, thereby driving the clamp arms A 131  to close, as shown in  FIG.  19   ; 
     Step 6: releasing the threaded connection between the mandrel and the driving shaft A 141  and withdrawing the mandrel, so that the two branches of the fixing part A 220  restores a state of converging to the central axis, the locking nose A 221  is disengaged from the locking position A 114  of the supporting portion A 110 , and the valve clamping device A 100  is disconnected from the delivery device A 200 , and then withdrawing the delivery device A 200  from the body, resulting in an implanted state as shown in  FIG.  20   , at which time the valve clamping device A 100  pulls the anterior mitral leaflet Ala and the posterior mitral leaflet Alb of the mitral valve A 1  toward each other to obtain a double-orifice mitral valve and complete edge-to-edge repair of the mitral valve. 
     After implantation of the valve clamping device A 100 , the elastic adjusting portion A 120  is filled between the anterior mitral leaflet Ala and the posterior mitral leaflet Alb of the clamped mitral valve A 1  and abuts on the clamp arm A 131 , the elastomer A 123  of the adjustment portion A 120  (e.g., a mesh structure or a porous structure) has a cushioning effect on the pulsing valve leaflet A 1 , so that a pulling degree of the valve leaflet A 1  by the valve clamping device A 100  is adjustable to avoid damage to the valve leaflet A 1 ; the elastomer A 123  may be pressed and deformed following the pulsation of the valve leaflet A 1 , the resulting elastic force pushes a part of the valve leaflet A 1  close to the elastomer A 123  in a direction away from the base A 160 , at which time a clamping angle between the anterior mitral leaflet and the posterior mitral leaflet of the mitral valve is less than the opening angle between the clamp arms A 131  since the structure of the opening A 122  of the adjusting portion A 120  makes the axial movement of the elastomer A 123  toward the proximal end no longer restricted, which can reduce pulling of the valve leaflet A 1  by the valve clamping device A 100 , so that the pulling degree of the valve leaflet A 1  by the valve clamping device A 100  always maintains within a reasonable range; the elastomer A 123  can cushion direct scouring of blood flow to the inside of the valve clamping device A 100 , prevent the valve clamping device A 100  from falling off under the continuous scouring of blood, and also prevent blood from being deposited at a dead angle (G in  FIG.  5   ) between the clamping portions A 130  of the valve clamping device A 100  to form thrombus; when the elastomer A 123  is under pressure of the valve, a degree of deformation is generated, and the deformation degree increases with the increase of pressure so as to avoid that the pressing force of the clamp arm A 131  on the elastomer A 123  in turn acts on the clamp arm A 131  after gripping the valve leaflet A 1 , thereby ensuring that the gripping effect of the valve clamping device A 100  on the valve leaflet A 1  after release remains consistent with that before release. 
     Referring to  FIG.  21    to  FIG.  23   , compared with the valve clamping device of the first example, all mesh wires at the distal end A 321  of the mesh structure of the adjusting portion A 320  of the valve clamping device A 300  according to the second example of the present disclosure A 324  are fixedly sleeved on the supporting portion A 310 . That is, both ends A 322  and A 321  of the adjusting portion A 320  are open structures without a head. During assembly of the adjusting portion A 320 , the mesh wires A 324  at the distal end A 321  of the adjusting portion A 322  are directly fixed on the supporting portion A 310  through common detachable or non-detachable connection means such as welding, bonding and crimping, preferably welding connection in the present example. 
     Since the opening or closing of the clamping portion A 330  (for example, clamp arm) rotates around the pivot A 332  (for example, pin) close to the distal side of the adjusting portion A 320 , when the clamping portion A 330  is closed, the closer to the pivot A 332 , the smaller the space is. When the valve leaflet is clamped by the clamping portion A 330 , part of the valve leaflet A 1  fill in and accumulate at space D, which not only affects the closing of the valve clamping device, but also causes serious damage to the valve A 1  when the valve clamping device is forcibly closed due to the failure to find the filling of the valve leaflet A 1  at D in time. In the present example, since the distal end A 321  of the adjusting portion A 320  is an open structure without a head, the adjusting portion A 320  can better conform to the deformation of the valve leaflet A 1  in the process of closing of the valve clamping device A 300 . Meanwhile, the adjusting portion A 320  reduces a hard head and thus increases the space there, which is conducive to better closure of the whole valve clamping device A 300  after grasping the valve leaflet A 1 . 
     Referring to  FIG.  24   a   , compared with the valve clamping device of the first example, at least part of the outer surface of the mesh structure of the adjusting portion A 420  of the valve clamping device A 400  according to the third example of the present disclosure is coated with a film. In addition, a film can be coated to at least part of the outer surfaces of the clamping portion A 430  and the gripping portion A 450 . The film may be of a woven mesh structure and is provided with a plurality of mesh holes. The adjusting portion A 420 , the clamping portion A 430  and the gripping portion A 450  after coating have higher biocompatibility and enhanced frictional force, and thus have a better clamping effect on the valve leaflets. 
     For example, referring to  FIG.  24   b   , the outsides of the gripping arm A 451  and the clamp arm A 431  are covered with a first film and a second film respectively, and the outside of the elastomer of the adjusting portion A 420  is covered with a third film. The relationship between the aperture ratios of the three is: the aperture ratio of the third film&lt;the aperture ratio of the first film&lt;the aperture ratio of the second film. The aperture ratio refers to the percentage of the aperture area in the whole film area. The aperture ratio of the second film is large, so that the second film has better elasticity and elongation rate than the first film. When the clamp arm covered with the second film is opened and closed with respect to the fixed base, the second film can produce corresponding elastic deformation with the opening and closing of the clamp arm, and the second film always adheres to the clamp arm. The aperture ratio of the third film is the smallest, so that the elastomer can substantially hinder the passage of blood flow. 
     The mesh holes on the first film and the second film can let the blood pass through and prevent the thrombus from passing through, and the mesh hole on the third film can neither let the blood nor the thrombus pass through. The first film can allow blood to permeate through without affecting the normal flow of blood from the left atrium to the left ventricle, avoiding blood retention in the left atrium, thereby reducing the damage of blood pressure to the left atrium cavity; and the first film can also increase the contact area between the gripping arm and blood to cushion the inflowing blood flow, so as to avoid the falling off resulted from the deformation of the gripping arm caused by the inflowing blood flow impacting the valve clamping device as much as possible. The second film can make the blood flow circulate normally between the left atrium and the left ventricle, so as to reduce the blood pressure difference between the left atrium and the left ventricle; and the second film can also block a minute amount of thrombus entering the valve clamping device through the first film and leave the thrombus in the valve clamping device, so as to prevent thrombus from entering the left ventricle and entering the human blood circulation to induce stroke. 
     The elastomer with the third film can not only increase the biocompatibility, avoid tissue allergy and inflammatory reaction, and improve product safety; but also form an artificial barrier on the atrial side of the valve leaflet, block the thrombus in the blood, close the opening of the whole valve clamping device toward the atrial side, and avoid the repeated scouring of blood at the internal dead corner of the valve clamping device to form thrombosis, so as to avoid thrombosis. 
     The first film, the second film and the third film may be made of polyethylene terephthalate, polypropylene, polytetrafluoroethylene, polyurethane and other polymer materials. The materials of the three may be the same or different. In the present example, the three are made of PET. 
     Referring to  FIG.  25   a    to  FIG.  25   c   , compared with the valve clamping device of the first example, the adjusting portion A 520  of the valve clamping device according to the fourth example of the present disclosure has a freely hanging end and a distal head A 521 . The freely hanging end may have an opening A 522 , the adjusting portion A 520  comprises a plurality of first curved surfaces A 520   a  and a plurality of second curved surfaces A 520   b  adjacent to and smoothly connected to each other. That is, the first curved surface A 520   a  is only adjacent to the second curved surface A 520   b , and the second curved surface A 520   b  is only adjacent to the first curved surface A 520   a . The two opposite first curved surfaces A 520   a  face a clamp arm respectively, and the area of the second curved surface A 520   b  is less than that of the first curved surface A 520   a.    
     In the present example, the first curved surface A 520   a  with relatively small area faces the clamp arm, and the second curved surface A 520   b  with relatively large area is smoothly connected between the two first curved surfaces A 520   a . With the closing process of the valve clamping device, the first curved surface A 520   a  of the adjusting portion is pressed by the clamp arm and the valve leaflet, and the adjusting portion extends along the direction of the second curved surface A 520   b  and gradually fits in the valve leaflet, so as to better adapt to the shape of the valve leaflet and increase the contact area between the first curved surface A 520   a  and the valve leaflet, thereby reducing the gap between the valve clamping device and the valve leaflet and slowing down the blood flow and hinder the scouring of the blood flow to the valve clamping device. Preferably, the curvature of the first curved surface A 520   a  may also be greater than that of the second curved surface A 520   b , so that the adjusting portion presents a flat ellipsoid shape to avoid affecting the closing of the clamp arm. Further, in the present implementation mode, when the clamp arm is closed, the first curved surface A 520   a  of the adjusting portion is pressed by the clamp arm and the valve leaflet, and the adjusting portion extends along the direction of the second curved surface A 520   b . Since the first end of the adjusting portion is open, it will not hook the distal end of the delivery system, thereby ensuring that the valve clamping device is separated at the connecting position with the delivery device in the case of arbitrary deformation of the adjusting portion. 
     Referring to  FIGS.  26   a  and  26   b   , compared with the valve clamping device of the first example, the structure of the adjusting portion A 620  of the valve clamping device A 600  according to the fifth example of the present disclosure is the same as that of the adjusting portion A 120  of the first example, except that the clamping portion A 630  and the gripping portion A 650  cooperate differently to grip the valve leaflet. In the fifth example, the clamping portion A 630  comprises a group of clamp arms A 631  that can be opened or closed with respect to the supporting portion A 610  and the adjusting portion A 620 , the gripping portion A 650  comprises a pair of gripping arms A 651 , and the gripping portion A 650  is located between the clamping portion A 630  and the adjusting portion A 620 . 
     During delivery, the clamping portion A 630 , the gripping portion A 650  and the adjusting portion A 620  are accommodated in the distal end of the delivery device A 200 , the delivery device A 200  is sent to the left ventricle via a transapical route and then reaches the left atrium across the mitral valve orifice; the delivery device A 200  is withdrawn, so that the adjusting portion A 620  and the gripping portion A 650  gradually extend from the delivery device A 200  and open within the left atrium; the delivery device A 200  continues to be withdrawn until the clamping portion A 630  also extends from the delivery device A 200  and opens in the left ventricle; then the clamping portion A 630  is pushed to the distal end by the driving portion, the anterior and posterior leaflets of the mitral valve are respectively borne on the inner surfaces of the two clamp arms A 631  of the clamping portion A 630  respectively, the gripping portion A 650  and the adjusting portion A 620  are withdrawn toward the proximal end, that is, the gripping portion A 650  is driven to move in the direction of the clamping portion A 630 , thereby capturing the valve leaflet between the gripping portion A 650  and the clamping portion A 630 , then the clamping portion A 630  is driven to close with respect to the adjusting portion A 620  and the supporting portion A 610 , thereby fixing the anterior mitral leaflet and the posterior mitral leaflet respectively between one clamp arm A 631  and one gripping arm A 651  disposed correspondingly to the clamp arm A 631 , then the delivery device A 200  is pushed to the distal end until the valve clamping device A 600  gradually converges and is closed; and the valve clamping device is disconnected from the delivery device A 200 , thereby implanting the valve clamping device onto the mitral valve and drawing the anterior mitral leaflet and the posterior mitral leaflet of the mitral valve toward each other to form a double orifice structure. 
     Second Embodiment 
     First Example 
     Referring to  FIG.  29    to  FIG.  33   , an adequately fitted valve clamping device B 100  according to a first example of the present disclosure comprises: 
     a supporting portion B 110  with a certain axial length and comprising a first end B 111  and a second end B 115  provided oppositely; 
     an adjusting portion B 120  comprising a first end B 121  and a second end B 123  oppositely provided, and a self-expanding body B 125  located between the first end B 121  and the second end B 123 ; and 
     a clamping portion B 130 , which is provided on the outside of the adjusting portion B 120  and can be opened or closed with respect to the adjusting portion B 120 . 
     The first end B 121  of the adjusting portion B 120  of the valve clamping device B 100  is movably sleeved outside the supporting portion B 110 , and the second end B 123  of the adjusting portion B 120  is sleeved outside the supporting portion B 110  and is fixedly connected to the supporting portion B 110 . The first end B 121  of the adjusting portion B 120  is located between the first end B 111  of the supporting portion B 110  and the second end B 123  of the adjusting portion B 120 , or the first end B 121  of the adjusting portion B 120  is closer to the first end B 111  of the supporting portion B 110  than the second end B 123  of the adjusting portion B 120 . 
     Referring to  FIG.  29    and  FIG.  38    to  FIG.  42   , the valve clamping device B 100  of the first example is provided with a connecting portion (not marked) detachably connected (such as threaded connection or snap connection) to the delivery device B 200  on the second end B 115  of the supporting portion B 110 . The delivery device B 200  pushes the valve clamping device B 100  into the heart via a catheter, and the second end B 115  of the supporting portion B 110  is a proximal end of the valve clamping device B 100 , the first end B 111  of the supporting portion B 110  is a distal end thereof, the second end B 123  of the adjusting portion B 120  is a proximal end thereof, and the first end B 121  of the adjusting portion B 120  is a distal end thereof. It should be noted that in other examples, the valve clamping device may intervene the heart via a transapical route, so the second end of the supporting portion is a distal end of the valve clamping device, the first end of the supporting portion is a proximal end thereof, the second end of the adjusting portion is a distal end thereof, and the first end of the adjusting portion is a proximal end thereof. 
     Please also refer to  FIG.  29    to  FIG.  33   . The valve clamping device B 100  mainly comprises two states: one is the opened state, and the other is the closed state. In the opened state, the adjusting portion B 120  is in a natural state without external force, and the diameter of the self-expanding body B 125  of the adjusting portion B 120  in the natural state gradually increases from the first end B 121  of the adjusting portion B 120  to the second end B 123  of the adjusting portion B 120 , that is, the overall shape of the adjusting portion B 120  is approximately an inverted cone shape, the first end B 121  of the adjusting portion B 120  substantially forms the apex of the inverted cone shape, and the part near the second end B 123  of the adjusting portion B 120  forms the bottom of the inverted cone shape. In the first example, one end of the clamping portion B 130  is rotationally connected to the first end B 111  of the supporting portion B 110 , so that the clamping portion B 130  can open or close around the adjusting portion B 120  with the rotating connection part between the clamping portion B 130  and the first end B 111  of the supporting portion B 110  as a center. There is axial spacing between the first end B 121  of the adjusting portion B 120  and the first end B 111  of the supporting portion B 110 . When the adjusting portion B 120  is subjected to radial pressing, the first end B 121  of the adjusting portion B 120  can move axially toward the first end B 111  of the supporting portion B 110 , and when the clamping portion B 130  centers on the rotating connection part between the clamping portion B 130  and the first end B 111  of the supporting portion B 110  and is closed around the adjusting portion B 120  to clamp the valve leaflet B 1 , the adjusting portion B 120  is subjected to radial retraction and axial elongation due to the pressing of the clamping portion B 130 . It should be noted that in other examples, one end of the clamping portion B 130  can also be rotationally connected to other parts, as long as the part is close to the first end B 111  of the supporting portion B 110 , so that the clamping portion B 130  is provided on the outside of the supporting portion B 110  and can be opened or closed with respect to the adjusting portion B 120  to clamp the valve leaflet. 
     It should be noted that in the closed state, since the second end B 123  of the adjusting portion B 120  is fixedly connected to the supporting portion B 110 , the first end B 121  of the adjusting portion B 120  is movably sleeved on the supporting portion B 110 , the axial movement of the second end B 123  of the adjusting portion B 120  and its adjacent part of the self-expanding body B 125  is limited. The self-expanding body B 125  will extend axially toward the first end B 121  of the adjusting portion B 120 , at which time the self-expanding body B 125  will retract radially under the pressing of the clamping portion B 130 . With the extension of the first end B 121  of the adjusting portion B 120  toward the valve edge of the valve leaflet B 1 , the overall shape of the adjusting portion B 120  can be complementary to the shape of the opening of the clamping portion B 130 , and still presents an inverted cone shape. Part of the self-expanding body B 125  near the second end B 123  of the adjusting portion B 120  is located at the conical bottom of the inverted cone shape, that is, the self-expanding body B 125  gradually converges toward the central axis of the adjusting portion B 120  to the first end B 121  of the adjusting portion B 120 , and part of the self-expanding body B 125  near the second end B 123  of the adjusting portion B 120  can fit closely in the valve leaflet B 1  without a radial gap, which can increase the fitting area between the valve leaflet B 1  and the adjusting portion B 120 , improve the elastic fit between the valve leaflet B 1  and the adjusting portion B 120 , and make the valve leaflet B 1  and the adjusting portion B 120  adequately fit as compared with the related art. Accordingly, the second end B 123  of the adjusting portion B 120  and its adjacent part of the self-expanding body B 125  can provide a large radial support force for the valve leaflet B 1 , and thus improve the clamping force to firmly clamp the valve leaflet B 1 , reduce the risk of the valve leaflet B 1  falling off between the clamping portion B 130  and the adjusting portion B 120 , and improve the implantation stability of the valve clamping device B 100 ; meanwhile, the close fit between the part of the self-expanding body B 125  near the second end B 123  of the adjusting portion B 120  and the valve leaflet B 1  can block the blood regurgitating from the clamping gap and optimize the regurgitation treatment effect. In addition, the adjusting portion B 120  can adaptively adjust its shape depending on the clamping degree of the clamping portion B 130 , which can ensure that the adjusting portion B 120  can adequately fit in the valve leaflet under any clamping degree. 
     It should be noted that in the closed state, the first end B 121  of the adjusting portion B 120  can extend toward the valve edge to be closer to the valve edge position as compared with the related art, which further increases the fitting area between the valve leaflet B 1  and the adjusting portion B 120  and further improves the elastic fit between the valve leaflet B 1  and the adjusting portion B 120 . 
     In addition, since the first end B 121  of the adjusting portion B 120  is movably sleeved on the supporting portion B 110 , the adjusting portion B 120  has a strong axial deformation ability. When radially compressed into the delivery sheath for in vivo delivery, the valve clamping device B 100  is easy to be compressed into the sheath. 
     Specifically, referring to  FIG.  29    and  FIG.  34    to  FIG.  37   , the supporting portion B 110  can be a circular tube body, a square column tube body or an oblate tube body with both ends axially penetrated. The present example adopts a circular tube body. As mentioned above, the distal end of the circular tube body is the first end B 111 , and the proximal end is the second end B 115 . The second end B 115  of the supporting portion B 110  can be surrounded and shielded by the part of the self-expanding body B 125  near the second end B 123  of the adjusting portion B 120  in the closed state and the opened state, so as not to be exposed from the adjusting portion B 120 , thereby preventing the second end B 115  from directly contacting the valve leaflet, preventing the second end B 115  from wearing the valve leaflet with the long-term pulsation of the valve leaflet, and improving the implantation safety. 
     The supporting portion B 110  is also provided with an axial through-hole shaped penetrating channel B 113  to cooperate with the driving portion B 140  and the delivery device B 200 . At least two locking positions B 114  are provided on the tube wall of the circular tube body of the supporting portion B 110  for detachable connection with the delivery device B 200 . For example, a locking nose B 221  is provided on the delivery device B 200 . After the locking nose B 221  is locked into the locking position B 114 , the delivery device B 200  is lockingly connected to the supporting portion B 110  to deliver the valve clamping device B 100 . When the locking nose B 221  is separated from the locking position B 114 , the delivery device B 200  is separated from the valve clamping device B 100 . It should be noted that the structure of the supporting portion B 110  is only an example but not a limitation of the present disclosure. Based on the teachings of the present disclosure, other structures of the supporting portion B 110  adopted by one skilled in the art are within the protection scope of the present disclosure. 
     Referring to  FIG.  29    to  FIG.  33   , the self-expanding body B 125  of the adjusting portion B 120  is of a mesh structure, preferably a mesh structure formed by weaving wires or cutting a pipe with a shape memory function, such as hyper-elastic materials such as nickel iron alloy wires. Under the same closed degree of the clamping portion B 130 , the adjusting portion B 120  can adapt to the spacing between different valve leaflets and produce adaptive deformation, so as to adjust the pulling degree of the valve leaflets by the valve clamping device B 100 . The adjusting portion B 120  has a hollow accommodation cavity (not marked), and the part of the supporting portion B 110  between the second end B 115  and the first end B 111  is provided in the hollow accommodation cavity. 
     The self-expanding body B 125  comprises a first section B 124 , a second section B 126  and a third section B 128  successively connected. The first section B 124  extends from the second end B 123  of the adjusting portion B 120  toward the second end B 115  of the supporting portion B 110 , and the first section B 124  forms a bowl-like recessed area B 122  with respect to the second section B 126  (as shown in  FIG.  31    and  FIG.  32   a   ). The first section B 124  surrounds outside the second end B 115  of the supporting portion B 110 , or the second end B 115  of the supporting portion B 110  is located in the recessed area B 122 . The second end B 115  of the supporting portion B 110  can be surrounded and shielded by the first section B 124  of the self-expanding body B 125  in the closed state and the opened state of the valve clamping device B 100 , so as not to be exposed from the adjusting portion B 120 . The second section B 126  continues to extend radially outward from the first section B 124 . The third section B 128  extends radially inward from the second section B 126  toward the first end B 111  of the supporting portion B 110  to the first end B 121  of the adjusting portion B 12 . In the first example, the terminal end of the recessed area B 122  (the end of the first section B 124  close to the second end B 123  of the adjusting portion B 120  is defined as the terminal end of the recessed area B 122 ) extends toward the first end B 111  of the supporting portion B 110  to the second end B 123  of the adjusting portion B 120 . 
     When the adjusting portion B 120  is produced, first a woven mesh tube with two ends open is prepared, one end of the woven mesh tube is sleeved on a lining rod, and a molding sleeve is sleeved outside one end of the woven mesh tube to form the second end B 123  of the adjusting portion B 120 ; then the other end of the woven mesh tube is pulled outward and downward, so that the woven mesh tube is everted on the forming mold; next, heat setting treatment is carried out to form an adjusting portion B 120  in an approximate inverted cone shape overall as shown in  FIG.  32   a    to  FIG.  32   b   , and the other end of the woven mesh tube forms a first end B 121  with an opening of the adjusting portion B 120  below one end of the woven mesh tube, so that the adjusting portion B 120  is obtained after removing the molding sleeve and molding mold. 
     When the adjusting portion B 120  and the supporting portion B 110  are assembled, the part between the second end B 115  and the first end B 111  of the supporting portion B 110  penetrates the hollow accommodation cavity of the adjusting portion B 120 . The second end B 123  of the adjusting portion B 120  is fixedly connected to the supporting portion B 110  through the fixing part B 80 , and the fixing part B 80  may be a steel sleeve. The second end B 123  of the adjusting portion B 120  penetrates between the steel sleeve and the outer surface of the supporting portion B 110 , then the second end B 123  of the adjusting portion B 120  is fixedly connected to the supporting portion B 110  by laser welding the steel sleeve and the supporting portion B 110 . It should be noted that in other examples, the second end B 123  of the adjusting portion B 120  may be fixedly connected to the supporting portion B 110  by welding without the fixing part B 80 . In the present example, the second end B 123  of the adjusting portion B 120  penetrates into the fixing part B 80  toward the first end B 111  of the supporting portion B 110 , and if the orientation of the second end B 123  of the adjusting portion B 120  in  FIG.  30    is defined as up and the orientation of the first end B 121  of the adjusting portion B 120  is defined as down, that is, the second end B 123  of the adjusting portion B 120  penetrates into the fixing part B 80  from up to down. The diameter of the opening of the first end B 121  of the adjusting portion B 120  may be equal to or slightly larger than the diameter of the supporting portion B 110 , so as to be movably sleeved on the supporting portion B 110 , so that the first end B 121  of the adjusting portion B 120  can slide smoothly along the axial direction of the supporting portion B 110 . Since the second end B 123  of the adjusting portion B 120  is fixedly connected to the supporting portion B 110 , and the first end B 121  of the adjusting portion B 120  is movably sleeved on the supporting portion B 110 , the center of gravity of the whole valve clamping device B 100  is always located in the axial direction of the supporting portion B 110 , so the valve clamping device B 100  has good self-centricity and is not easy to tilt. 
     More specifically, during the process of change from the opened state to the closed state of the valve clamping device B 100 , the radial dimension of the second section B 126  of the self-expanding body B 125  (marked with F in  FIG.  30   ) is preferably 4 mm to 15 mm, more preferably 5 mm to 10 mm, and the radial dimension of the first end B 121  of the adjusting portion B 120  is 1 mm to 5 mm, more preferably 1.2 mm to 3 mm, so that the overall inverted cone shape of the adjusting portion B 120  after being compressed can not only adapt to the spacing between different valve leaflets, but also have a fitting area with the valve leaflets as large as possible. 
     Referring to  FIG.  29   ,  FIG.  30    and  FIG.  33   , in the closed state of the valve clamping device B 100 , that is, when the valve leaflet B 1  is clamped between the adjusting portion B 120  and the clamping portion B 130 , since the second end B 123  of the adjusting portion B 120  is fixedly connected to the supporting portion B 110 , the first end B 121  of the adjusting portion B 120  is movably sleeved on the supporting portion B 110 , the axial movement of the second end B 123  of the adjusting portion B 120 , the first section B 124  and the second section B 126  of the self-expanding body B 125  is limited. The adjusting portion B 120  extends axially toward the first end B 121 , and the self-expanding body B 125  retracts radially under the pressing of the clamping portion B 130 , but the first section B 124  resists the inward deformation of the second section B 126 , and the second section B 126  transfers the resistance to the corresponding part of the third section B 128  connected thereto. With the first end B 121  of the adjusting portion B 120  extending toward the valve edge of the valve leaflet B 1 , the overall shape of the adjusting portion B 120  presents an inverted cone shape complementary to the shape of the opening of the clamping section B 130 . The second section B 126  is located at the conical bottom of the inverted cone shape, and the third section B 128  gradually converges toward the central axis of the adjusting portion B 120  from the second section B 126  to the first end B 121 . The whole third section B 128  of the self-expanding body B 125  can closely fit in the valve leaflet B 1  without a radial gap. The elastic fit between the valve leaflet B 1  and the adjusting portion B 120  can be improved, so that the valve leaflet B 1  and the adjusting portion B 120  can adequately fit. Accordingly, the adjusting portion B 120  can provide a large radial support force for the valve leaflet B 1  to improve the clamping force to firmly clamp the valve leaflet B 1 . As shown in  FIG.  33   , the second section B 126  of the self-expanding body B 125  is not lower than the end face of the free end of the closed clamping portion, so that the length of the valve leaflet B 1  clamped between the clamping portion B 130  and the adjusting portion B 120  is substantially the same as the length of the clamping portion B 130 . 
     It should be noted that in other examples, the outside and/or inside of the adjusting portion B 120  of the mesh structure can be covered with a biocompatible film. On the one hand, the film can be used as a flow blocking film to block the blood flowing back from the clamp gap, thereby improving the effect of regurgitation treatment, and preventing the blood from entering the adjusting portion B 120  to form thrombosis; on the other hand, the film can make the valve clamping device B 100  more biocompatible. The material of the film may be, but is not limited to PTFE, EPTFE, polyester, silicone and other biocompatible polymers. 
     Certainly, the adjusting portion B 120  is not limited to a mesh structure, but may also be other elastic and self-expandable hollow structures. For example, a colloidal silica of a dense structure or a sponge of a porous structure. The second end of the adjusting portion of the dense structure or the porous structure is fixedly sleeved on the supporting portion B 110 , and the first end is axially movably sleeved on the supporting portion B 110 . Similar first section, second section and third section may be set between the second end and the first end, or the valve leaflet may be adequately fitted in the adjusting portion based on the same principle. 
     Referring to  FIGS.  29  and  33  to  37   , the clamping portion B 130  comprises at least two clamp arms B 131 , and may generally comprise at least one group of the clamp arms B 131 , and each group of the clamp arms B 131  comprises two clamp arms B 131  symmetrically provided with respect to the adjusting portion B 120 . The clamping portion B 130  in the present example comprises a group of the clamp arms B 131 . It should be noted that this is only an example. One skilled in the art can select an appropriate number of the clamp arms B 131  as needed, for example, two or more groups of clamp arms. It should be noted that three or more clamp arms B 131  may also be provided in each group as required. For example, the three valve leaflets of the tricuspid valve may be clamped with three clamp arms B 131  that can be opened and closed relatively, so as to treat tricuspid regurgitation; alternatively, two of the valve leaflets of the tricuspid valve may be clamped by a pair of clamp arms B 131  to reduce or treat tricuspid regurgitation. 
     In the present example, the valve clamping device B 100  further comprises a driving portion B 140  connected to the clamping portion B 130  to drive the clamping portion B 130  to open or close with respect to the adjusting portion B 120 . Specifically, the driving portion B 140  is connected to each of the clamp arms B 131 . For example, the driving portion B 140  is respectively connected to two clamp arms B 131  in a group of clamp arms B 131  to drive each of the clamp arms B 131  to rotate around the adjusting portion B 120 , so that the clamp arm B 131  is close to or away from the adjusting portion B 120 . In the delivering state, the driving portion B 140  drives the clamp arm B 131  to close around the adjusting portion B 120 , so as to reduce the outer diameter of the valve clamping device B 100  and facilitate delivering; and after the valve clamping device B 100  is opened in the heart, the driving portion B 140  drives the clamp arm B 131  to clamp the valve leaflet between the clamp arm B 131  and the adjusting portion B 120  to realize valve clamping. 
     In a preferred implementation mode of the present example, the valve clamping device B 100  further comprises a gripping portion, and may generally comprise at least one group of gripping arms B 151 , and each group of the gripping arms B 151  comprises two gripping arms B 151  symmetrically provided with respect to the adjusting portion B 120 . The gripping portion (e.g., the gripping arm B 151 ) is provided between the clamping portion B 130  (e.g., the clamp arm B 131 ) and the adjusting portion B 120 , and can be opened or closed with respect to the adjusting portion B 120 . The gripping portion is at least partially accommodated in the inner surface of the clamping portion B 130 . Certainly, three or more gripping arms B 151  may also be provided in each group as required, so as to cooperate with the clamp arm B 131  to realize the valve capture function. 
     In the delivering state, the gripping portion is at least partially accommodated in the inner surface of the clamping portion B 130 , that is, the gripping arm B 151  is at least partially accommodated in the inner surface of the clamp arm B 131 , thereby reducing the outer diameter of the valve clamping device B 100  and facilitating delivery. After the clamping arm B 131  cooperates with the gripping arm B 151  to capture the valve leaflet, the gripping arm B 151  presses the valve leaflet into the inner surface of the clamping arm B 131 , which can increase the contact area between the clamping arm B 131  and the valve leaflet and increase the clamping force on the valve leaflet. 
     The valve clamping device B 100  further comprises a base B 160  fixedly connected to the supporting portion B 110 , and each of the clamp arms B 131  is rotationally connected to the base B 160 . Specifically, the proximal end of the base B 160  is fixedly connected to the first end B 111  of the supporting portion B 110 . It should be noted that this part is defined as the term “base” for the convenience of description, and the structure to realize the function of the base B 160  may also be the first end B 111  itself of the supporting portion B 110 . Therefore, the definition of the term “base” should not limit the scope of the present disclosure. The clamp arms B 131  in each group are rotationally connected together on the base B 160  by a pivot B 132 . The first end B 121  of the adjusting portion B 120  is axially separated from the base B 160 . Driven by the driving portion B 140 , the clamp arms B 131  cooperate with each other and can open and close around the adjusting portion B 120  together. 
     In the present example, the driving portion B 140  comprises a driving shaft B 141 , a connecting seat B 142  and two connecting rods B 143 . One end of each of the connecting rods B 143  is rotationally connected to the clamping portion B 130 , and the other end is rotationally connected to the connecting seat B 142 ; one end of the driving shaft B 141  is fixedly connected to the connecting seat B 142 , and the other end movably penetrates in the base B 160 . Specifically, one end of each connecting rod B 143  is rotationally connected to the clamp arm B 131 , and the other end is rotationally connected to the connecting seat B 142  by a pivot B 144 , that is, each of the clamp arms B 131  is rotationally connected to the connecting seat B 142  of the driving shaft B 141  through the connecting rod B 143  on the corresponding side. The driving shaft B 141  movably passes through the base B 160 . When sliding axially with respect to the base B 160 , the driving shaft B 141  drives the connecting rod B 143  to rotate and drives the clamp arm B 131  to open or close centered on a rotationally connected part thereof with the base B 160 . 
     Specifically, the driving portion B 140  comprises at least one group of connecting rods B 143 , and the setting of the connecting rods B 143  corresponds to the setting of the clamp arms B 131 . For example, if two clamp arms B 131  are used in  FIG.  34   , two cooperating connecting rods B 143  are correspondingly provided. One end of the connecting rod B 143  is rotationally connected to the connecting seat B 142  through the pivot B 144  such as a pin, and the other end is rotationally connected to the corresponding clamp arm B 131  through a pivot such as a pin. Each of the clamp arms B 131  is rotationally connected to the base B 160  through the pivot B 132  such as a pin. When the driving shaft B 141  moves axially toward the first end B 111  of the supporting portion B 110  with respect to the base B 160 , the driving shaft B 141  drives the connecting rod B 143  to move. Under the pull of the connecting rod B 143 , the clamp arm B 131  rotates around the pivot B 132  and opens with respect to the base B 160 . When the driving shaft B 141  moves axially with respect to the base B 160  toward the second end B 115  of the supporting portion B 110 , the connecting rod B 143  pushes the clamp arm B 131  to rotate around the pivot B 132  and close with respect to the base B 160 . The shape of the connecting seat B 142  may be any structure such as a hemisphere, a spherical crown or a warhead shape, so as to make the valve clamping device B 100  easier to be pushed in the body. The driving shaft B 141  and the connecting seat B 142  may be an integrated structure or a non-integrated structure. In order to ensure the safety after implantation, the driving shaft B 141  and the connecting seat B 142  are made of biocompatible materials such as polyester, silicone, stainless steel, cobalt alloy, cobalt chromium alloy and titanium alloy, preferably stainless steel or cobalt chromium alloy with high hardness. 
     Preferably, as shown in  FIG.  34   , the valve clamping device B 100  further comprises a locking portion B 170  provided in the base B 160 , which restricts the relative movement of the driving shaft B 141  and the base B 160 . In the delivering state, the locking portion B 170  restricts the relative movement of the driving shaft B 141  and the base B 160 , so as to ensure that the clamping portion B 130  is always in a closed state with respect to the adjusting portion B 120  and the supporting portion B 110  and avoid accidental opening of the clamping portion B 130 ; after reaching the vicinity of the mitral valve, the restriction of the locking portion B 170  on the driving shaft B 141  is unlocked, and the clamping portion B 130  can be driven to open and support the valve leaflet with respect to the adjusting portion B 120  and the supporting portion B 110  by the driving portion B 140 ; after clamping the valve leaflet, the locking portion B 170  again restricts the relative movement of the driving shaft B 141  and the base B 160 , so as to maintain the clamped state of the valve leaflet B 1 . The locking portion of any suitable structure in the related art can be adopted, which is not be described here. 
     Referring to  FIG.  29    and  FIG.  33   , further, the terminal end of each clamp arm B 131  (the end of the clamp arm B 131  away from a rotating connection part thereof or the free end is defined as the terminal end of the clamp arm B 131 ) is also provided with a flanging section B 137 . Viewed from the front view of  FIG.  33   , the flanging section B 137  is a cambered surface overturned toward the outside of the terminal end of the clamp arm B 131 , and the radius of the cambered surface is preferably 1 mm to 2 mm. When the clamp arms B 131  are closed with respect to the adjusting portion B 120  to clamp the valve leaflet B 1  therebetween, the valve leaflet B 1  fits in the flanging section B 137  of a cambered surface, which increases the supporting area of the terminal end of the clamp arm B 131  against the valve leaflet B 1 , can avoid the local stress concentration of the valve leaflet B 1  at the terminal end of the clamp arm B 131  and effectively reduce the damage to the valve leaflet caused by the repeated friction between the terminal end edge of the clamp arm B 131  and the valve leaflet B 1  with the beating of the heart. When the clamp arm B 131  abuts against the adjusting portion B 120 , the self-expanding body B 125  of the adjusting portion B 120  is axially protruded from the flanging section B 137 , or the second section B 126  of the self-expanding body B 125  is higher than the flanging section B 137 , so as to ensure that the length of the valve leaflet B 1  clamped between the clamp arm B 131  and the third section B 128  of the self-expanding body is not less than the length of the clamp arm B 131 . 
     Referring to  FIG.  37    to  FIG.  41   , the present disclosure also provides a valve clamping system comprising the valve clamping device B 100  and a delivery device B 200 , wherein the delivery device B 200  comprises a pushing sheath B 210  with a certain axial length and a mandrel (not shown in the figure) movably penetrating in the pushing sheath B 210 . The pushing sheath B 210  is detachably connected to the supporting portion B 110 , and the mandrel is detachably connected to the driving portion B 140  for driving the opening and closing of the clamping portion B 130 . In the present example, the proximal end of the driving shaft B 141  is provided with an external thread, and the mandrel is threadedly connected to the driving shaft B 141 , so that the axial movement of the driving shaft B 141  can be controlled outside the patient through the mandrel. It should be noted that only part of structure of the delivery device is illustrated here, and any suitable structure in the related art can be adopted for other parts, which is not described here. 
     Specifically, the proximal outer wall of the supporting portion B 110  is symmetrically provided with at least one locking position B 114  connected to the cavity of the supporting portion B 110 , the distal end of the pushing sheath B 210  is provided with a connecting member B 220 , the connecting member B 220  comprises two branches, and the terminal end of each branch is a protruded locking nose B 221 . In the natural state, the two branches point to the central axis of connecting member B 220 . During assembly, the connecting member B 220  is inserted into the supporting portion B 110 , and then the mandrel of the delivery device B 200  is inserted into the pushing sheath B 210  until the mandrel is inserted into the connecting member B 220 , and the two branches of the connecting member B 220  are pushed outward. The locking noses B 221  at the branch terminal ends are locked into the two locking positions B 114  of the supporting portion B 110 , so as to connect the supporting portion B 110  with the connecting member B 220 , that is, connect the valve clamping device B 100  with the delivery device B 200 . When the mandrel is withdrawn from the connecting member B 220  and the pushing sheath B 210 , the two branches restores the inward natural state, and the locking nose B 221  is separated from the locking position B 114  of the supporting portion B 110 , so that the connection between the valve clamping device B 100  and the delivery device B 200  is released. The connecting member B 220  may be made of materials with certain hardness and elasticity such as nickel and titanium. The pushing sheath B 210  may adopt a multi-layer composite tube. The mandrel may be made of stainless steel or nickel titanium alloy. 
     Referring to  FIG.  35    and  FIG.  37   , the interior of the supporting portion B 110  is provided with a through hole as the penetrating channel B 113  of the driving shaft B 141 , and the driving shaft B 141  axially slidingly penetrates in the penetrating channel B 113  of the supporting portion B 110  and is fixedly connected to the connecting seat B 142 . After the clamping portion B 130  and the gripping portion B 150  cooperate and capture the valve leaflet, the driving shaft B 141  is driven to move axially by the mandrel to drive the clamp arm B 131  to be completely closed with respect to the supporting portion B 110 , so that the valve clamping device B 100  is in a closed state and falls below the valve. After that, the connection between the mandrel and the driving shaft B 141  may be released, the mandrel is withdrawn from the connecting member B 220 , and the locking nose B 221  is separated from the locking position B 114  of the supporting portion B 110 , so as to disconnect the valve clamping device B 100  from the delivery device B 200 . 
     Referring to  FIG.  38    to  FIG.  42   , a use process of the valve clamping device B 100  of the present disclosure is explained below taking anterograde approach and repair of the mitral valve via the atrial septum-left atrium through the a transcatheter route as an example. 
     Step 1: pushing the driving shaft B 141  and the valve clamping device B 100  connected thereto from the left atrium B 2  to the left ventricle B 3  via the mitral valve B 1  by a guiding device such as a bendable sheath (not shown in the figure), as shown in  FIG.  38   ; 
     Step 2: adjusting the valve clamping device B 100  to approach the anterior mitral leaflet B 1   a  and the posterior mitral leaflet B 1   b  of the mitral valve B 1 ; 
     Step 3: unlocking the locking portion B 170  in the base B 160 , pushing the mandrel and the driving shaft B 141  to the distal end, driving the clamp arm B 131  to open with respect to the supporting portion B 110 , and adjusting the direction of the clamp arm B 131 , at which time a relative position of the clamp arm B 131  and the anterior and posterior mitral leaflets B 1   a , B 1   b  of the mitral valve B 1  can be observed by an X-ray device, so that the clamp arm B 131  is perpendicular to a coapting line of the mitral valve B 1 , as shown in  FIG.  39   ; 
     Step 4: withdrawing the entire valve clamping device B 100  to the proximal end to let the clamp arm B 131  hold the valve leaflet B 1  on the left ventricle B 3  side, and releasing the gripping arms B 151  on both sides, wherein the gripping arm B 151  on each side presses the valve leaflet B 1  on the atrium side and captures the valve leaflet B 1  together with the clamp arm B 131  on the side, as shown in  FIG.  40   ; 
     Step 5: pulling the mandrel and the driving shaft B 141  to the proximal end when the anterior mitral leaflet B 1   a  and the posterior mitral leaflet B 1   b  of the mitral valve B 1  are captured between a pair of the clamp arms B 131  and the gripping arms B 151  respectively, thereby driving the clamp arms B 131  to close, as shown in  FIG.  41   ; 
     Step 6: releasing the threaded connection between the mandrel and the driving shaft B 141  and withdrawing the mandrel, so that the two branches of the connecting member B 220  restores a state of converging to the central axis, the locking nose B 221  is disengaged from the locking position B 114  of the supporting portion B 110 , and the valve clamping device B 100  is disconnected from the delivery device B 200 , and then withdrawing the delivery device B 200  from the body, resulting in an implanted state as shown in  FIG.  42   , at which time the valve clamping device B 100  pulls the anterior mitral leaflet B 1   a  and the posterior mitral leaflet B 1   b  of the mitral valve B 1  toward each other to obtain a double orifice mitral valve and complete edge-to-edge repair of the mitral valve. 
     After the valve clamping device B 100  is implanted, the elastic adjusting portion B 120  is filled between the anterior mitral leaflet B 1   a  and the posterior mitral leaflet B 1   b  of the clamped mitral valve B 1  and provides a radial support force for the valve leaflet B 1 . The adjusting portion B 120  has a cushioning effect on the pulsating valve leaflet B 1 , so that the pulling degree of the valve leaflet B 1  by the valve clamping device B 100  can be adjusted to avoid damaging the valve leaflet B 1 . 
     Second Example 
     Referring to  FIG.  43    to  FIG.  45   , compared with the valve clamping device B 100  of the first example, in the valve clamping device B 100 ′ of a second example of the present disclosure, the structure of the supporting portion B 110 , the clamping portion B 130 , the driving portion B 140 , the gripping portion B 151 , and the like remains the same, which will not be repeated here, but the structure of the adjusting portion B 120 ′ has changed. 
     Specifically, in the second example, the adjusting portion B 120 ′ adds a bending section B 129  to the self-expanding body compared with the adjusting portion B 120  in the first example. The bending section B 129  is connected between the second end B 123  of the adjusting portion B 120 ′ and the first section B 124  of the self-expanding body. Preferably, the cross-section shape of the bending section B 129  is an arc shape recessed toward the first end B 121  of the adjusting portion B 120 ′. The first section B 124  and the bending section B 129  still form a recessed area B 122 ′ with respect to the second section B 126 , and the terminal end of the recessed area B 122 ′ (one end of the bending section B 129  close to the second end B 123  of the adjusting portion B 120 ′ is defined as the terminal end of the recessed area B 122 ′) extends toward the second end B 115  of the supporting portion B 110  to the second end B 123  of the adjusting portion B 120 ′. 
     When the adjusting portion B 120 ′ is produced, first a woven mesh tube with both ends open is prepared, the woven mesh tube is sleeved on a lining rod, and then a molding sleeve is sleeved outside an upper end of the woven mesh tube to form the second end B 123  of the adjusting portion B 120 ′; then the lower end of the woven mesh tube is pushed upward (the orientation of the second end B 123  of the adjusting portion B 120 ′ in  FIG.  44    is defined as up, and the orientation of the first end B 121  is defined as down), and heat setting treatment is carried out on the woven mesh tube with the molding mold to form the adjusting portion B 120 ′ with an overall shape still approximate to an inverted cone shape as shown in  FIG.  44    and  FIG.  45   , and the lower end of the woven mesh tube forms a first end B 121  with an opening of the adjusting portion B 120 ′ below the upper end of the woven mesh tube, and the molding sleeve and the molding mold are removed to obtain the adjusting portion B 120 ′. 
     When the adjusting portion B 120 ′ and the supporting portion B 110  are assembled, the part between the second end B 115  and the first end B 111  of the supporting portion B 110  penetrates in the hollow accommodation cavity of the adjusting portion B 120 . The second end B 123  of the adjusting portion B 120 ′ is fixedly connected to the supporting portion B 110  through the fixing part B 80 , and the fixing part B 80  may be a steel sleeve. The second end B 123  of the adjusting portion B 120  penetrates between the steel sleeve and the outer surface of the supporting portion B 110 , and then the second end B 123  of the adjusting portion B 120 ′ is fixedly connected to the supporting portion B 110  by laser welding the steel sleeve and the supporting portion B 110 . In the present example, the second end B 123  of the adjusting portion B 120 ′ penetrates into the fixing part B 80  toward the second end B 115  of the supporting portion B 110 , that is, the second end B 123  of the adjusting portion B 120 ′ penetrates in the fixing part B 80  from down to up. 
     When the valve clamping device B 100 ′ is closed, the bending section B 129  resists the inward deformation of the first section B 124 , and the resistance is superimposed and transferred to the corresponding part of the third section B 128  connected to the second section B 126  to further improve the elastic fit between the valve leaflet and the adjusting portion B 120 , so that the valve leaflet can adequately fit in the adjusting portion B 120 . Accordingly, the adjusting portion B 120  can provide a greater radial support force for the valve leaflet, and further increase the clamping force to firmly clamp the valve leaflet. 
     Third Example 
     As shown in  FIG.  46   , compared with the valve clamping device of the first example, in the valve clamping device of a third example of the present disclosure, the structure of the supporting portion, the clamping portion, the driving portion, the gripping portion, and the like remains the same, which will not be repeated here, but the structure of the self-expanding body B 125 ′ of the adjusting portion has changed. 
     The self-expanding body B 125 ′ in the third example further comprises an adaptation section B 127  in addition to the first section B 124 , the second section B 126  and the third section B 128 . The adaptation section B 127  is connected between the second section B 126  and the third section B 128 , and extends radially outward with respect to the third section B 128  (the radially inward is toward the central axis of the supporting portion B 110 ; and the radially outward is away from the central axis of the supporting portion B 110 ). The adaptation section B 127  is provided corresponding to the flanging section B 137  at the terminal end of the clamp arm, and the shape of a side thereof facing the flanging section B 137  is complementary to the cambered surface of the flanging section B 137 . 
     When the clamp arms are closed with respect to the adjusting portion B 120  to clamp the valve leaflet therebetween, the adaptation section B 127  is protruded from the flanging section B 137  in the axial direction, or the adaptation section B 127  is higher than the flanging section B 137 . Part of the valve leaflet is clamped between the adaptation section B 127  and the flanging section B 137 . On the one hand, the valve leaflet forms a fit in the cambered surface of the flanging section B 137  to increase the supporting area of the clamp arm terminal end against the valve leaflet, which can avoid the local stress concentration of the valve leaflet at the terminal end of the clamp arm and effectively reduce the damage to the valve leaflet caused by repeated friction between the terminal end edge of the clamp arm and the valve leaflet with the beating of the heart; on the other hand, the valve leaflet also forms a fit in the arc-shaped adaptation section B 127 , which further increases the fit area between the valve leaflet and the adjusting portion, improves the elastic fit between the valve leaflet and the adjusting portion, and makes the valve leaflet fit better in the adjusting portion. Accordingly, the adjusting portion can provide a sufficient radial support force for the valve leaflet, and further increase the clamping force to firmly clamp the valve leaflet. 
     Fourth Example 
     Referring to  FIG.  47    to  FIG.  49   , compared with the valve clamping device B 100  of the first example, in a valve clamping device B 400  of a fourth example of the present disclosure, the structure of the adjusting portion B 120  remains the same, which will not be repeated here, but the structure of the supporting portion B 410 , the clamping portion B 430  and the driving portion B 440  has changed. 
     Specifically, in the fourth example, the clamping portion B 430  comprises at least two clamp arms, and may generally comprise at least a group of clamp arms, each group of the clamp arms comprises two clamp arms symmetrically provided with respect to the adjusting portion B 120 . The clamping portion  40  in the present example comprises a group of clamp arms. Each of the clamp arms is provided with at least one anchor B 431 . When the clamp arm is closed with respect to the adjusting portion B 120 , the anchor B 431  can abut on the valve leaflet and make the valve leaflet embedded in the grid of the adjusting portion B 120  of a mesh structure, so as to hold the valve leaflet tissue through the anchor B 431  on the basis that the adjusting portion B 120  and the clamp arm clamp the valve leaflet. 
     The driving portion B 440  comprises a driving shaft B 410 , an automatic closing unit B 445  and at least two connecting rods B 443 . One end of each of the connecting rods B 443  is rotationally connected to a corresponding clamp arm, and the other end is directly rotationally connected to the driving shaft B 441  through a pin shaft; the driving shaft B 441  movably penetrates in the supporting portion B 410 ; and the automatic closing unit B 445  is connected to two clamp arms to make the clamping portion B 430  abut against the adjusting portion B 120  in a natural state. 
     The base B 416  is integrated with the first end B 411  of the supporting portion B 410 , and the two clamp arms are rotationally connected to the base B 416 . The supporting portion B 410  is provided with an axial groove B 419  through which the pin shaft passes. When the driving shaft B 441  drives the pin shaft to move toward the first end B 411  of the supporting portion B 410  in the axial groove B 419 , the connecting rod B 443  is driven to overcome obstruction of the automatic closing unit B 445  to open the two clamp arms relatively. 
     In the present example, the automatic closing unit B 445  is a U-shaped elastic sheet, and two ends of the U-shaped elastic sheet are respectively connected to a clamp arm. When the driving shaft B 441  does not apply thrust to the pin shaft, the U-shaped elastic sheet drives the two clamp arms to close and abut against the adjusting part B 120  with its own reset. It should be noted that in other examples, the automatic closing unit B 445  may also be an elastic member such as a V-shaped elastic sheet or a torsional spring. 
     Fifth Example 
     Referring to  FIG.  50   , compared with the valve clamping device B 400  in the fourth example, a valve clamping device B 400 ′ in a fifth example of the present disclosure replaces the adjusting portion B 120  in the fourth example by the adjusting portion B 120 ′ in the second example, and other structures remain the same and will not be repeated here. 
     Sixth Example 
     Referring to  FIG.  51    and  FIG.  52   , compared with the valve clamping device B 100  of the first example, the structure of the adjusting portion B 120  of the valve clamping device B 500  in a sixth example of the present disclosure remains the same and will not be repeated here, but the structure of the clamping portion B 530 , the driving portion B 540 , and the like has changed. 
     In the present example, the base B 516  is integrated with the first end B 511  of the supporting portion B 510 , and one end of the clamp arm of the clamping portion B 530  is connected to the base B 516 . The driving portion B 540  comprises a driving shaft B 541  and at least two elastic driving arms B 545 . One end of the elastic driving arm B 545  is fixedly connected to one end of the driving shaft B 541 , the other end of the elastic driving arm B 545  is connected to the other end of the clamp arm, and the other end of the driving shaft B 545  movably penetrates in the supporting portion B 510 ; the elastic driving arm B 545  is configured to make the clamping portion B 530  abut against the adjusting portion B 120  in a natural state; one end of the gripping arm B 551  is connected to the clamp arm of the clamping portion B 530 , and when the valve clamping device B 500  is opened, the gripping arm B 551  is controlled by a pull wire (not shown in the figure) in the delivery device to open with respect to the clamp arm, so as to allow the valve leaflet to enter between the gripping arm B 551  and the clamp arm. 
     In the present example, the two clamp arms and the two elastic driving arms B 545  are integrated, that is, the two clamp arms themselves are elastic. When the driving shaft B 541  moves toward the first end B 511  of the supporting portion B 510 , the two clamp arms are opened with respect to each other by overcoming the obstruction of the two elastic driving arms B 545 ; and when the driving shaft B 541  does not apply thrust to the elastic driving arm B 545 , the two elastic driving arms B 545  use their own reset to drive the two clamp arms to almost close and abut against the adjusting portion B 120 . It should be noted that when the driving shaft B 541  continuously pushes toward the first end B 511  of the supporting portion B 510 , the connecting position between the clamp arm and the driving arm B 545  gradually approaches the driving shaft B 541  until the clamp arm and the driving arm B 545  are substantially in a straight line, and then a pull wire is used to control the gripping arm B 551  to fit in the adjusting portion B 120 . In this state, it is easier to put the whole flattened valve clamping device B 500  into the sheath. 
     In addition, the valve clamping device B 500  of the present example can realize dynamic balance of the valve clamping state: when the valve leaflet applies a relatively large pulling force to the valve clamping device B 500 , the elastic driving arm B 545  and clamp arm can adjust the clamping angle within a certain range without being separated from the valve leaflet, so as to prevent the valve leaflet from being damaged by an excessive pulling force. 
     Seventh Example 
     Referring to  FIG.  53   , compared with the valve clamping device B 500  in the sixth example, a valve clamping device B 500 ′ in a seventh example of the present disclosure replaces the adjusting portion B 120  in the sixth example by the adjusting portion B 120 ′ in the second example. Other structures remain the same and will not be repeated here. 
     Eighth Example 
     Referring to  FIG.  54    and  FIG.  55   , compared with the valve clamping device B 100  in the first example, in a valve clamping device B 600  in an eighth example of the present disclosure, only the structure of the supporting portion B 610  is changed, and other structures remain the same and will not be repeated here. 
     In the present example, the connection part between the supporting portion B 610  and the delivery device B 200 ′ is no longer provided at the second end as in the first example, but a connection part B 670  is provided on the base B 660  at the first end of the supporting portion B 610 , and the connection part B 670  is detachably connected to the pushing sheath of the delivery device B 200 ′. Specifically, the connection part B 670  and the pushing sheath of the delivery device B 200 ′ are respectively provided with a splicing structure with complementary shapes, and an outer sheath B 70  is movably sleeved outside the pushing sheath. When the outer sheath B 70  wraps the splicing structure with complementary shapes, the supporting portion B 610  remains connected to the delivery device B 200 ′, and when the outer sheath B 70  is withdrawn and the splicing structure with complementary shapes is exposed, the supporting portion B 610  can be disconnected from the delivery device B 200 ′. 
     As shown in  FIG.  55   , the delivery device B 200 ′ of the present example can push the valve clamping device B 600  into the heart via a transapical route to perform edge-to-edge repair of the mitral valve. It should be noted that before the two clamp arms are closed, the outer sheath B 70  should still wrap the splicing structure with complementary shapes; after the two clamp arms are closed, first the threaded connection between the mandrel and the driving shaft is released, and the mandrel is withdrawn, then the outer sheath B 70  is withdrawn to expose the splicing structure, so that the connection between the valve clamping device B 600  and the delivery device B 200 ′ can be released. 
     It should be noted that the valve clamping system provided in the present disclosure comprises any of the above valve clamping devices and a delivery device capable of delivering the valve clamping device from the outside of the body to the vicinity of the mitral valve and clamping the valve leaflets. 
     It should be noted that the valve clamping device and the valve clamping system provided in the present disclosure can also perform edge-to-edge repair of a tricuspid valve, as long as the corresponding intervention path (e.g., femoral vein to inferior vena cava to right atrium—right ventricle) is selected and an appropriate number of valve clamping devices are implanted according to the number of valve leaflets to be repaired (for example, three valve clamping devices are implanted to clamp anterior and posterior mitral leaflets, posterior and septal leaflets, and septal and anterior mitral leaflets of a tricuspid valve respectively). 
     Third Embodiment 
     First Example 
     Referring to  FIG.  56    to  FIG.  58   , an adaptive valve clamping device C 100  according to a first example of the present disclosure can be used for edge-to-edge repair of a mitral or tricuspid valve to treat mitral or tricuspid regurgitation. In order to ensure safety of the adaptive valve clamping device C 100  after implantation, the adaptive valve clamping device C 100  is made of biocompatible materials overall. The adaptive valve clamping device C 100  for edge-to-edge repair of a mitral valve is described as an example in detail below. An operator uses a delivery device C 200  to push the adaptive valve clamping device C 100  to the patient&#39;s mitral valve, and then remotely operate the adaptive valve clamping device C 100  to clamp the anterior and posterior mitral leaflets of the mitral valve together. When the valve leaflets of the mitral valve are coapted edge-to-edge, the operator can release the connection between the delivery device C 200  and the adaptive valve clamping device C 100 , so as to implant the adaptive valve clamping device C 100  into the patient, fix the anterior and posterior mitral leaflets of the mitral valve together, and realize the “edge-to-edge repair” of the mitral valve. 
     Referring to  FIG.  59   , the adaptive valve clamping device C 100  comprises a supporting portion C 110 , a hollow adjusting portion C 120  and a clamping portion C 130 . The supporting portion C 110  comprises a first seat body C 112  and a second seat body C 114  connected to the first seat body C 112 . The first seat body C 112  is provided in the adjusting portion C 120 . The adjusting portion C 120  comprises a first end C 122  and a second end C 124  provided oppositely, and a self-expanding body C 121  between the first end C 122  and the second end C 124 . The first end C 122  of the adjusting portion C 120  is movably sleeved outside the second seat body C 114  and can move axially with respect to the second seat body C 114 , and the second end C 124  of the adjusting portion C 120  hangs in the air. The first seat body C 112  is closer to the second end C 124  of the adjusting portion C 120  than the second seat body C 114 . The clamping portion C 130  comprises at least two clamp arms C 132 , and each of the clamp arms C 132  is rotationally connected to the supporting portion C 110 . The rotating connection part of the clamp arm C 132  is close to the first end C 122  of the adjusting portion C 120 , and the clamp arm C 132  rotates around the supporting portion C 110  to be close to or away from the adjusting portion C 120 . 
     In the adaptive valve clamping device C 100  of the above example, the first end C 122  of the adjusting portion C 120  is movably sleeved outside the second seat body C 114  of the supporting portion C 110 , the second end C 124  of the adjusting portion C 120  hangs in the air and is relatively closer to the first seat body C 112 , and the adjusting portion C 120  may move axially with respect to the supporting portion C 110 . When the clamp arm C 132  of the clamping portion C 130  approaches the adjusting portion C 120  to close and clamp the valve leaflet, the whole adjusting portion C 120  axially moves to the first seat body C 112 , which can increase space S of the rotating connection part of the clamp arm C 132  close to the adjusting portion C 120 , so as to avoid excessive accumulation of valve leaflets in the space S. During the closing process of the clamping portion C 130 , the adjusting portion C 120  can better adapt to the deformation of the valve leaflet at the space S to adjust the overall pulling of the valve leaflet by the clamping portion C 130 , so as to make the axial force of the valve leaflet more balanced, which is conducive to better closing of the clamping portion C 130  after gripping the valve leaflet and avoids damage to the valve leaflet at the space S. 
     It should be noted that the clamp arm C 132  of the clamping portion C 130  is rotationally connected to the supporting portion C 110 , and the first end C 122  of the adjusting portion C 120  is movably sleeved outside the second seat body C 114  of the supporting portion C 110 , that is, the clamping portion C 130  is provided outside the adjusting portion C 120 . The clamp arm C 132  of the clamping portion C 130  rotates around the supporting portion C 110  to approach the adjusting portion C 120 , that is, the clamping portion C 130  closes with respect to the adjusting portion C 120 ; and the clamp arm C 132  of the clamping portion C 130  rotates around the supporting portion C 110  away from the adjusting portion C 120 , that is, the clamping portion C 130  opens with respect to the adjusting portion C 120 . 
     The second end C 124  of the adjusting portion C 120  hangs in the air and is closer to the first seat body C 112  of the supporting portion C 110 . The first seat body C 112  is provided in the adjusting portion C 120 , so there is a gap between the second end C 124  of the adjusting portion C 120  and the first seat body C 112  of the supporting portion C 110 , which can avoid interference or winding between the second end C 124  of the adjusting portion C 120  and the first seat body C 112  of the supporting portion C 110 , so as to ensure the implantation safety of the instrument. The self-expanding body C 121  of the adjusting portion C 120  may be deformed in the radial and axial directions, so the adjusting portion C 120  comprises a natural state and a compressed state. The self-expanding body C 121  may be made of a shape memory material. When the clamping portion C 130  opens with respect to the adjusting portion C 120 , the clamping portion C 130  has no contact with the adjusting portion C 120 , and the adjusting portion C 120  is in a natural state; and when the clamping portion C 130  is closed with respect to the adjusting portion C 120 , the adjusting portion C 120  is radially compressed and extends axially to the first seat body C 112  of the supporting portion C 110  in a compressed state. When the clamping portion C 130  is closed with respect to the adjusting portion C 120 , the adjusting portion C 120  is gradually compressed radially and extends axially to the first seat body C 112  of the supporting portion C 110 , and the spacing between the second end C 124  of the adjusting portion C 120  and the first seat body C 112  of the supporting portion C 110  increases gradually. Since the first end C 122  of the adjusting portion C 120  is movably sleeved outside the second seat body C 114  of the supporting portion C 110 , the first end C 122  of the adjusting portion C 120  will move to the first seat body C 112  of the supporting portion C 110 , thereby increasing the space S of the rotating connection part of the clamp arm C 132  close to the first end C 122  of the adjusting portion C 120 , so as to avoid excessive accumulation of valve leaflets in the space S and ensure that the clamping portion C 130  is normally closed without damaging the valve leaflet. 
     Meanwhile, since the first end C 122  of the adjusting portion C 120  is movably sleeved outside the second seat body C 114  of the supporting portion C 110 , the second end C 124  of the adjusting portion C 120  hangs in the air, and the adjusting portion C 120  is no longer limited by the supporting portion C 110 , which improves the axial deformation ability of the adjusting portion C 120  and enhances a bending deformation ability thereof along the axial direction. Therefore, when the adaptive valve clamping device C 100  is radially compressed into the delivery sheath for in vivo delivery, it is not only easy to be compressed into the sheath, but can also adapt to blood vessels with different bending curvatures during delivery in the blood vessel, so as to facilitate the passage of the delivery sheath in the blood vessel, thereby reducing the damage to the blood vessel wall. The first end C 122  of the adjusting portion C 120  is movably sleeved outside the second seat body C 114  of the supporting portion C 110 , and the second end C 124  of the adjusting portion C 120  hangs in the air, so that the center of gravity of the adjusting portion C 120  is always located in the axial direction of the supporting portion C 110  (i.e. the axial line of the adjusting portion C 120 ). Therefore, the self-centricity of the adjusting portion C 120  is good and is not easy to tilt. 
     In addition, after the implantation of the adaptive valve clamping device C 100 , in the process of clamping the valve leaflet and the adjusting portion C 120  by the clamping portion C 130 , since the axial deformation of the adjusting portion C 120  is not limited, the elastic fit between the valve leaflet and the adjusting portion C 120  can be improved, and then the adaptability of the physiological structure of the valve leaflet in different patients can be improved. 
     Referring to  FIG.  70    to  FIG.  74   , in the adaptive valve clamping device C 100  of the present example, the supporting portion C 110  is detachably connected (such as threaded connection and snap connection) to the delivery device C 200 . The delivery device C 200  pushes the adaptive valve clamping device C 100  into the heart via a catheter. The second end C 124  of the adjusting portion C 120  is a proximal end of the adaptive valve clamping device C 100 , and the first end C 122  of the adjusting portion C 120  is a distal end thereof; and the first seat body C 112  of the supporting portion C 110  is close to the proximal end of the adaptive valve clamping device C 100 , while the second seat body C 114  is close to the distal end of the adaptive valve clamping device C 100 . It should be noted that in other examples, the adaptive valve clamping device C 100  can intervene in the heart through a transapical route, the second end C 124  of the adjusting portion C 120  is a distal end of the adaptive valve clamping device C 100 , and the first end C 122  of the adjusting portion C 120  is a proximal end thereof; and the first seat body C 112  of the supporting portion C 110  is close to the distal end of the adaptive valve clamping device C 100 , while the second seat body C 114  is close to the proximal end of the adaptive valve clamping device C 100 . 
     The adaptive valve clamping device C 100  is closed during delivery, and can be released and open when delivered to the mitral valve of the patient to clamp the valve leaflet. The first seat body C 112  of the supporting portion C 110  is located in the hollow adjusting portion C 120  whether in the delivering state or in the released and opening state and will not be exposed in the delivery device C 200  or in the heart, so as to avoid the scouring of blood and minimize the formation of thrombosis after implantation. Moreover, after the implantation of the adaptive valve clamping device C 100 , the direct contact between the supporting portion C 110  and the valve leaflet is avoided, and accompanied by the long-term pulsation of the valve leaflet, the supporting portion C 110  is prevented from wearing the valve leaflet or even causing perforation of the valve leaflet, thus improving the safety. 
     Referring to  FIG.  59    and  FIG.  60   , the first end C 122  of the adjusting portion C 120  is provided with a first head C 126  which is movably sleeved outside the second seat body C 114 . There is a clearance fit between the inner cavity surface of the first head C 126  and the outer surface of the second seat body C 114 . In this way, the first end C 122  of the adjusting portion C 120  is drawn in through the first head C 126 , and the first head C 126  can move on the second seat body C 114  of the supporting portion C 110 , so that the adjusting portion C 120  can move with respect to the supporting portion C 110 . 
     Specifically, the first head C 126  is a double-layer structure comprising two coaxially nested tube bodies. One end of the sandwich cavity between the two tube bodies is closed, and the other end is open for drawing in the first end C 122  of the adjusting portion C 120 . Both ends of the tube body with smaller radial size are open, and an inner cavity thereof is the inner cavity of the first head C 126 . The first head C 126  may be a metal steel sleeve. 
     In order to ensure that the adjusting portion C 120  can be movably sleeved on the second seat body C 114  of the supporting portion C 110 , the fit clearance between the inner cavity surface of the first head C 126  and the outer surface of the second seat body C 114  ranges from 0.01 mm to 3 mm, preferably 0.05 mm to 3 mm. Preferably, the fit clearance between the inner cavity surface of the first head C 126  and the outer surface of the second seat body C 114  ranges from 0.05 mm to 1 mm, so as to avoid shaking of the first head C 126  and the adjusting portion C 120  outside the supporting portion C 110  caused by the excessive fit clearance. More preferably, the fit clearance between the inner cavity surface of the first head C 126  and the outer surface of the second seat body C 114  ranges from 0.05 mm to 0.2 mm, which can not only avoid the free sliding and rotation of the first head C 126  on the second seat body C 114  caused by the excessive fit clearance, but can also make the first head C 126  move axially with respect to the second seat body C 114  by applying an appropriate force to the first head C 126  and/or the second seat body C 114 . 
     Further, the surface roughness of the inner cavity surface of the first head C 126  ranges from 0.1 μm to 2.5 μm, and/or the surface roughness of the outer surface of the second seat body C 114  ranges from 0.1 μm to 2.5 μm. It should be noted that the inner cavity surface of the first head C 126  and/or the outer surface of the second seat body C 114  are set to be rough, so that a contact surface between the first head C 126  and the second seat body C 114  is not smooth, which can further ensure the effect of restricting the free sliding and rotation of the first head C 126  on the second seat body C 114 . The range of the surface roughness is set reasonably, and the first head C 126  can still move axially with respect to the second seat body C 114  by applying an appropriate force to the first head C 126  and/or the second seat body C 114 . 
     The second end C 124  of the adjusting portion C 120  has an opening C 128 , which is convenient for the delivery device C 200  to penetrate into the adjusting portion C 120  and connect with the supporting portion C 110 . Meanwhile, there is no head or other parts exposed outside the second end C 124 , which can avoid thrombosis and wear of the valve leaflet. The size of the opening C 128  is less than or equal to the size of the first seat body C 112  of the supporting portion C 110 , so as to ensure that the first seat body C 112  of the supporting portion C 110  will not extend from the adjusting portion C 120  in the natural state and the compressed state. 
     The self-expanding body C 121  of the adjusting portion C 120  has a hollow accommodation cavity, and the first seat body C 112  of the supporting portion C 110  is provided in the hollow accommodation cavity. In an implementation mode, the self-expanding body C 121  is of a mesh structure, which is woven or cut from a shape memory material. Metal materials, polymer materials or metal polymer composites may be selected, preferably a shape memory metal material with certain elasticity such as stainless steel, cobalt chromium alloy or nickel titanium. For example, a hyper-elastic nickel titanium alloy material may be selected for weaving or cutting to form the natural state after heat setting treatment. Specifically, all the mesh wires of the mesh structure are fixedly drawn in the sandwich cavity of the first head C 126  at the first end C 122 , and all the mesh wires of the mesh structure are enclosed at the bending part at the edge of the second end C 124  to form an opening C 128 . The shape of the bending may be set as required, such as bending once, bending back after winding for several times to form at least one ring, or the like. Further, referring to  FIG.  60   , the adjusting portion C 120  further comprises an annular structure C 123  provided at the edge of the second end C 124  to stabilize the shape of the opening C 128 . All the mesh wires of the mesh structure at the second end C 124  are wound and connected to the annular structure C 123 . The annular structure C 123  is made of flexible or elastic materials, and its wire diameter is larger than that of the mesh wire of the woven mesh structure, so as to provide a certain support force for the opening C 128  of the mesh structure, but not affect the axial deformation ability and bending ability of the mesh structure. A polytetrafluoroethylene (PTFE) coating may be applied on the surface of nickel titanium alloy by spraying, dipping and the like to have superior corrosion resistance, chemical resistance and wear resistance, and thus can play the role of surface protection, anti-corrosion, and prolongation of the service life of parts. Meanwhile, since PTFE has a good friction coefficient, the damage of self-expanding body C 121  to the valve leaflet can be effectively reduced. 
     Certainly, the self-expanding body C 121  of the adjusting portion C 120  may be other elastic hollow structures. For example, the self-expanding body C 121  may be of a dense structure or a porous structure, the dense structure is colloidal silica, and the porous structure is a sponge. The edge of the second end C 124  of the dense structure or the porous structure forms an opening C 128 , and the first end C 122  is provided with the first head C 126 . 
     For the self-expanding body C 121  of the dense structure, the self-expanding body C 121  is filled between the anterior and posterior mitral leaflets of the mitral valve, which can completely hinder the blood flow from scouring the interior of the adaptive valve clamping device C 100 ; prevent the adaptive valve clamping device C 100  from falling off due to the scouring of the high-speed flowing blood during fine tuning, and prevent the clamping portion C 130  from falling off under the continuous impact of blood after implantation; and prevent the blood from depositing and forming thrombus at the dead corner between the clamping portions C 130  of the adaptive valve clamping device C 100 . The self-expanding body C 121  of the mesh structure has better elastic deformation ability, which can better adapt to the anatomical structure of the mitral valve and avoid damage to the valve leaflet caused by excessive pulling of valve leaflets. 
     Further, a film (not shown) is applied to at least part of the outer surface of the self-expanding body C 121  of the mesh structure. The film may be a woven mesh structure with a plurality of mesh holes. The self-expanding body C 121  with a film can not only further improve the blocking effect of blood flow and reduce central regurgitation, but also increase biocompatibility, avoid allergy and inflammatory reaction of the valve tissue, improve product safety, and form an artificial barrier on the atrial side of the valve leaflet, thereby blocking the outflow of thrombus formed by repeated scouring of blood at the internal dead corner of the adaptive valve clamping device C 100 . The film material may be made of polyethyleneglycol terephthalate (PET), polypropylene (PP), polytetrafluoroethylene, polyurethane and other polymer materials. Preferably, the film material is made of PET. 
     In order to prevent the self-expanding body C 121  from affecting the relative opening and closing between the clamping portion C 130  and the supporting portion C 110  and affecting the clamping effect on the valve leaflet, the diameter of a part of the self-expanding body C 121  close to the first end C 122  should be less than the diameter of other parts of the self-expanding body C 121 . For example, in the example of  FIG.  60   , the middle of the self-expanding body C 121  is cylindrical, both ends are cones, and the cone angles of the cones at both ends are the same. It should be noted that the self-expanding body C 121  may also be any other shape, as long as the diameter of the part close to the first end C 122  does not affect the clamping effect. For example, a spindle structure with the same cone angle at both ends shown in  FIG.  61    or a structure with different cone angles at both ends shown in  FIG.  62   . 
     Referring to  FIG.  63    and  FIG.  64   , the self-expanding body C 121  may comprise a plurality of first curved surfaces C 1212  and a plurality of second curved surfaces C 1214 . The first curved surface C 1212  and the second curved surface C 1214  are adjacent to each other and smoothly connected together, that is, the first curved surface C 1212  is only adjacent to the second curved surface C 1214 , and the second curved surface C 1214  is only adjacent to the first curved surface C 1212 , and ends of the plurality of first curved surfaces C 1212  and the plurality of second curved surfaces C 1214  are connected to each other and form an opening C 128 . The first curved surface C 1212  faces the clamping portion C 130 , and the area of the second curved surface C 1214  is less than that of the first curved surface C 1212 . With the closing of the adaptive valve clamping device C 100 , the first curved surface C 1212  is pressed by the clamping portion C 130  and the valve leaflet, and the adjusting portion C 120  extends along the axial direction and gradually fits in the valve leaflet to ensure the contact area with the valve leaflet, so as to better adapt to the shape of the valve leaflet. By increasing the contact area between the first curved surface C 1212  and the valve leaflet, the gap between the adaptive valve clamping device C 100  and the valve leaflet is reduced, so as to slow down the blood flow and hinder the blood flow from scouring the adaptive valve clamping device C 100 . Preferably, the curvature of the first curved surface C 1212  may also be greater than that of the second curved surface C 1214 , so that the self-expanding body C 121  presents a flat ellipsoid shape, so as to avoid affecting the closing of the clamping portion C 130  and adapt more to the anatomical structure of the valve leaflet. 
     In other implementation modes, the first end C 122  of the adjusting portion C 120  is provided with a first head C 126 , and the second end C 124  of the adjusting portion C 120  is provided with a second head. There is a clearance fit between the inner cavity surface of the first head C 126  and the outer surface of the second seat body C 114 . In this way, the first end C 122  and the second end C 124  of the adjusting portion C 120  are both drawn in by the head. In the present implementation mode, the specific structure of the second head is the same as that of the first head C 126 , which is the aforementioned double-layer structure, which will not be repeated here. 
     Referring to  FIG.  65   , the supporting portion C 110  further comprises a third seat body C 116  connected to the second seat body C 114 . The inner diameter of the first head C 126  is less than the outer diameter of the first seat body C 112 , and the inner diameter of the first head C 126  is less than the outer diameter of the third seat body C 116 . Thus, the movement stroke of the first head C 126  at the first end C 122  of the adjusting portion C 120  is limited by the first seat body C 112  and the third seat body C 116 , and the adjusting portion C 120  may move axially on the second seat body C 114  without falling off from the second seat body C 114 . Since the adjusting portion C 120  has a certain weight, under the action of gravity, the initial position of the adjusting portion C 120  is located at the distal end of the second seat body C 114  and close to the proximal end of the third seat body C 116 . 
     Specifically, the inner diameter of the first head C 126  should be at least 0.01 mm, preferably 0.05 mm to 3 mm smaller than the outer diameter of the first seat body C 112 . The inner diameter of the first head C 126  should be at least 0.01 mm, preferably 0.05 mm to 3 mm smaller than the outer diameter of the third seat body C 116 . Both the first head C 126  and the second seat body C 114  may be of a circular tube structure, which is convenient for the axial movement of the first head C 126  on the second seat body C 114 . The first seat body C 112  and the second seat body C 114  may be integrally molded, or separately molded and then fixed by welding. The third seat body C 116  and the second seat body C 114  may be fixed together by common detachable or non-detachable connection means such as welding, bonding, threaded connection, crimping, and bolt locking. The present example adopts welding connection. Specifically, the distal end of the second seat body C 114  of the supporting portion C 110  may penetrate in from the second end C 124  of the adjusting portion C 120 , and penetrate out from the first end C 122  of the adjusting portion C 120 ; and then the distal end of the third seat body C 116  and the proximal end of the second seat body C 114  are connected integrally by welding. 
     In other implementation modes, the supporting portion C 110  further comprises the third seat body C 116  connecting the second seat body C 114 . The end of the second seat body C 114  connected to the first seat body C 112  is provided with a limiting part (not shown in the figure). The inner diameter of the first head C 126  is less than the outer diameter of the limiting part, and the inner diameter of the first head C 126  is less than the outer diameter of the third seat body C 116 . Thus, the movement stroke of the first head C 126  at the first end C 122  of the adjusting portion C 120  is limited by the limiting part and the third seat body C 116 , and the adjusting portion C 120  may move axially on the second seat body C 114  without falling off from the second seat body C 114 . 
     Referring to  FIG.  65    to  FIG.  69   , the supporting portion C 110  is provided with a penetrating channel C 111  along the axial direction to cooperate with the driving portion C 140  and the delivery device C 200 . The first seat body C 112  and the second seat body C 114  are circular tubes with both end faces axially penetrated. At least two locking positions C 1122  are provided on the tube wall of the first seat body C 112  for detachable connection with the locking nose C 222  of the delivery device C 200 . After the locking nose C 222  (referring to  FIG.  69   ) of the delivery device C 200  is locked into the locking position C 1122 , the delivery device C 200  is lockingly connected to the supporting portion C 110  to deliver the adaptive valve clamping device C 100 . When the locking nose C 222  is disconnected from the locking position C 1122 , the adaptive valve clamping device C 100  is separated from the delivery device C 200  and released in the body. 
     The distal end of the third seat body C 116  is a square structure and the proximal end thereof is a trapezoid structure. The distal end of the third seat body C 116  is radially provided with an accommodation cavity C 1162  penetrating the two opposite sides of the third seat body C 116 . The proximal and distal ends of the second seat body C 114  are provided with a through hole axially penetrating the accommodation cavity C 1162 . Two opposite planes of the trapezoid structure of the proximal end of the second seat body C 114  are respectively provided with a connecting block C 1164 , and the connecting block C 1164  is provided with a connecting hole to be rotationally connected to the clamping portion C 130 . The cavity of the first seat body C 112 , the cavity of the second seat body C 114 , the through hole of the third seat body C 116  and the accommodation cavity C 1162  are connected to form a penetrating channel C 111 . It should be noted that the structure of the supporting portion C 110  here is only an example and is not a limitation of the present disclosure. Based on the teachings of the present disclosure, other structures of the supporting portion C 110  adopted by one skilled in the art are within the protection scope of the present disclosure. 
     Referring to  FIG.  56    and  FIG.  57   , the clamping portion C 130  is rotationally connected to the third seat body C 116  of the supporting portion C 110 . The clamping portion C 130  comprises at least two clamp arms C 132 , that is, at least two clamp arms C 132  are rotationally connected to the third seat body C 116  of the supporting portion C 110 , and at least two clamp arms C 132  are symmetrically provided in the circumferential direction with respect to the adjusting portion C 120 . Further, the adaptive valve clamping device further comprises a driving portion C 140  connected to each of the clamp arms C 132  to drive each of the clamp arms C 132  to rotate around the supporting portion C 110 , so as to drive each of the clamp arms C 132  to close by approaching the adjusting portion C 120  or open by departing from the adjusting portion C 120 . The clamp arms C 132  may be rotationally connected together on the third seat body C 116  through the connecting shaft C 134 . The connecting shaft C 134  passes through the connecting hole on the third seat body C 116  and each of the clamp arms C 132 , so as to rotationally connect the clamp arm C 132  to the third seat body C 116 . Then, driven by the driving portion C 140 , the clamp arms C 132  cooperate with each other and open or close with respect to rotation of the supporting portion C 110 . When the clamp arm C 132  is closed, the second end C 124  of the adjusting portion C 120  is slightly lower than the end face of the free end (i.e., the proximal end) of the clamp arm C 132 ; in this way, the adjusting portion C 120  will not be exposed from the proximal end face of the clamp arm C 132  after closing, thereby ensuring that the flanging terminal end of the clamp arm C 132  abuts against the valve leaflet to increase the contact area with the valve leaflet, comply with the angle and direction of the valve leaflet, and avoid the risk of thrombosis caused by excessive exposure of the adjusting portion C 120  in the left atrium. 
     In the illustrated example, the clamping portion C 130  comprises two clamp arms C 132  symmetrically provided in the circumferential direction with respect to the adjusting portion C 120  for clamping the two valve leaflets of the mitral valve. In other implementation modes, the clamping portion C 130  may comprise three clamp arms C 132  provided circumferentially around the adjusting portion C 120  for clamping three valve leaflets of the tricuspid valve. It should be noted that this is only an example, and one skilled in the art can select an appropriate number of clamp arms C 132  as needed, such as two, three or more clamp arms C 132 . In the delivering state, the driving portion C 140  drives the clamp arm C 132  to close around the adjusting portion C 120 , so as to reduce the outer diameter of the adaptive valve clamping device C 100  and facilitate delivering; and after the adaptive valve clamping device C 100  opens in the body, the driving portion C 140  drives the clamp arm C 132  to clamp the valve leaflets between the clamp arm C 132  and the adjusting portion C 120  to realize valve leaflet clamping. 
     Further, the adaptive valve clamping device C 100  comprises a gripping portion C 150 , which is provided between the clamp arm C 132  and the adjusting portion C 120  and may be close to or away from the clamp arm C 132  and at least partially accommodated in the inner surface of the clamp arm C 132  (as shown in  FIG.  56   ) in the natural state. It should be noted that in some examples, the gripping portion C 150  has a shape memory function, so as to be close to the clamp arm C 132  in the natural state; and in other examples, the gripping portion C 150  may be made of a material that does not have a shape memory function and drives the gripping portion C 150  to be close to the clamp arm C 132  by means of a push rod or the like. The gripping portion C 150  comprises at least two gripping arms C 152 . Generally, the number of the gripping arms C 152  is the same as the number of the clamp arms C 132 , and setting modes thereof are the same. In this way, the gripping arm C 152  cooperates with the clamp arm C 132  to realize the clamping function. 
     Preferably, the gripping arm C 152  is made of a shape memory material such as nickel titanium alloy, and the free end of the gripping arm C 152  is provided with an adjusting wire hole of an adjusting wire (not shown in the figure) for connecting the delivery device C 200 . The free end of the gripping arm C 152  may be controlled by the adjusting wire extending to the outside of the patient. In the delivering state, the free end of the gripping arm C 152  is tensioned by the adjusting wire and fits in the adjusting portion C 120 ; and when the clamp arm C 132  opens in the body and clamps the valve leaflet, the control of the adjusting wire on the free end is released to release the gripping arm C 152 , and the gripping arm C 152  restores the natural state due to its shape memory function and presses the valve leaflet to the clamp arm C 132 . 
     In the natural state, the gripping portion C 150  is at least partially accommodated in the inner surface of the clamping portion C 130 , that is, the gripping arm C 152  is at least partially accommodated in the inner surface of the clamp arm C 132 , so that the outer diameter of the adaptive valve clamping device C 100  in the delivering state can be reduced after the adaptive valve clamping device C 100  is closed, which is conducive to delivering. After the clamp arm C 132  and the gripping arm C 152  cooperate to clamp the valve leaflet, the recessed inner surface of the clamp arm C 132  can increase the contact area between the clamp arm C 132  and the valve leaflet, and causes the gripping arm C 152  to press the valve leaflet into the inner surface of the clamp arm C 132  to increase the clamping force on the valve leaflet. 
     Referring to  FIG.  57   , the driving portion C 140  comprises a driving shaft C 142 , a connecting seat C 144  and at least two connecting rods C 146 . One end of each of the connecting rods C 146  is connected to one clamp arm C 132 , and the other end is pivotally connected to the connecting seat C 144 . One end of the driving shaft C 142  is connected to the connecting seat C 144 , and the other end thereof movably penetrates in the third seat body C 116 . Specifically, the number of the connecting rods C 146  is consistent with the number of the clamp arms C 132 . One end of each of the connecting rods C 146  is connected to one clamp arm C 132 , and the other end thereof is connected to the connecting seat C 144  through the pivot C 148 . The driving shaft C 142  passes through the penetrating channel C 111  of the supporting portion C 110  along the axial direction and movably penetrates the third seat body C 116  to be connected to the connecting seat C 144 . When the driving shaft C 142  moves axially with respect to the third seat body C 116 , the connecting rod C 146  rotates and drives the clamp arm C 132  to open and close with respect to the third seat body C 116 . When the driving shaft C 142  moves axially to the distal end with respect to the third seat body C 116 , the connecting rod C 146  rotates and drives the clamp arm C 132  to open, and the adaptive valve clamping device C 100  is in the opened state; and when the driving shaft C 142  moves axially to the proximal end with respect to the third seat body C 116 , the connecting rod C 146  rotates and drives the clamp arm C 132  to close, and the adaptive valve clamping device C 100  is in the closed state. 
     In the illustrated example, the clamping portion C 130  comprises two clamp arms C 132 , and two cooperating connecting rods C 146  are correspondingly provided. The distal end of the clamp arm C 132  is rotationally connected to the third seat body C 116  through the connecting shaft C 134  such as a pin or bolt, the distal end of the connecting rod C 146  is rotationally connected to the connecting seat C 144  through the pivot C 148  such as a pin or bolt, and the proximal end of the connecting rod C 146  is connected to the clamp arm C 132 . When the driving shaft C 142  moves axially to the distal end with respect to the third seat body C 116 , the connecting rod C 146  rotates and drives the clamp arm C 132  to rotate around the connecting shaft C 134  and open with respect to the third seat body C 116 , and the adaptive valve clamping device C 100  is in the opened state. When the driving shaft C 142  moves axially to the proximal end with respect to the third seat body C 116 , the connecting rod C 146  rotates and drives the clamp arm C 132  to rotate around the connecting shaft C 134  and close with respect to the third seat body C 116 . 
     The shape of the connecting seat C 144  is of any structure such as a hemisphere, a spherical crown or a warhead shape, so as to make the adaptive valve clamping device C 100  easier to be pushed in the body. The driving shaft C 142  and the connecting seat C 144  may be an integrated structure or a non-integrated structure. The connecting seat C 144  may be fixedly provided at the distal end of the driving shaft C 142  by welding or other means. In order to ensure the safety after implantation, the driving shaft C 142  and the connecting seat C 144  are made of biocompatible materials such as polyester, silicone, stainless steel, cobalt alloy, cobalt chromium alloy and titanium alloy, preferably stainless steel or cobalt chromium alloy with high hardness. 
     Further, the driving portion C 140  further comprises a locking part C 141  provided in the third seat body C 116  which restricts the relative movement of the driving shaft C 142  and the third seat body C 116 . In the delivering state, the locking part C 141  restricts the relative movement of the driving shaft C 142  and the third seat body C 116 , so as to ensure that the clamping portion C 130  is always closed with respect to the adjusting portion C 120  and the supporting portion C 110 , and avoid accidental opening of the clamping portion C 130 . After the adaptive valve clamping device C 100  reaches the vicinity of the mitral valve, the restriction of the locking part C 141  on the driving shaft C 142  is unlocked, so that the clamping portion C 130  can be driven by the driving portion C 140  to open with respect to the adjusting portion C 120  and the supporting portion C 110  and clamp the valve leaflet. The locking part C 141  may be a combination of a deformed elastic sheet and a steel sheet in the related art, which will not be described here. 
     Referring to  FIG.  57    and  FIG.  58   , the first example of the present disclosure further provides a valve clamping system. The valve clamping system comprises the adaptive valve clamping device C 100  and the delivery device C 200 . The delivery device C 200  comprises a pushing shaft C 210  with a certain axial length and a mandrel (not shown in the figure) movably penetrating in the pushing shaft C 210 . The pushing shaft C 210  is detachably connected to the supporting portion C 110 , and the mandrel is configured to drive the clamp arm C 132  of the clamping portion C 130  to rotate around the supporting portion C 110 . It should be noted that only part of structure of the delivery device C 200  is listed here, and other parts can adopt any suitable structure in the related art, which will not be described here. 
     Specifically, the mandrel is detachably connected to the driving portion C 140 . The mandrel is configured to drive the clamp arm C 132  of the clamping portion C 130  by the driving portion C 140  to rotate around the supporting portion C 110 , so as to drive the clamping portion C 130  to open or close. Referring to  FIG.  68    and  FIG.  69   , the tube wall at the proximal end of the first seat body C 112  of the supporting portion C 110  is symmetrically provided with two locking positions C 1122  connected to the cavity. The distal end of the pushing shaft C 210  is provided with a fixing part C 220 . The fixing part C 220  comprises two branches, and the terminal end of each branch is a protruded locking nose C 222 . In the natural state, the two branches point to the central axis of the fixing part C 220 . When the adaptive valve clamping device C 100  and the delivery device C 200  are assembled, the fixing part C 220  at the distal end of the pushing shaft C 210  is inserted into the first seat body C 112  of the supporting portion C 110 , and then the mandrel is inserted into the pushing shaft C 210  until the mandrel is inserted into the fixing part C 220  to push the two branches of the fixing part C 220  outward, so that the locking noses C 222  at the terminal end of the branches are respectively locked into the locking positions C 1122 , and the supporting portion C 110  is connected to the pushing shaft C 210 , that is, the adaptive valve clamping device C 100  is connected to the delivery device C 200 . The proximal end of the driving shaft C 142  is provided with an external thread, and the mandrel is provided with an internal thread. The mandrel is threadedly connected to the driving shaft C 142  after being inserted into the fixing part C 220 , so that the axial movement of the driving shaft C 142  can be controlled through the mandrel. 
     When the mandrel is detached from the driving shaft C 142  and the mandrel is withdrawn from the fixing part C 220  and the pushing shaft C 210 , the two branches of the fixing part C 220  restore the inward natural state, and the locking nose C 222  is detached from the locking position C 1122  of the first seat body C 112 , so that the connection between the adaptive valve clamping device C 100  and the delivery device C 200  is released. The fixing part C 220  may be made of a material with certain hardness and elasticity such as nickel titanium. The pushing shaft C 210  may adopt a multi-layer composite tube. The mandrel may be made of stainless steel. 
     It should be noted that after the adaptive valve clamping device C 100  is connected to the delivery device C 200 , the adaptive valve clamping device C 100  is closed, and the adaptive valve clamping device C 100  is delivered to the patient&#39;s mitral valve through the delivery device C 200 . Then the driving shaft C 142  is driven by the mandrel to move to the distal end along the axial direction. The driving shaft C 142  drives the connecting rod C 146  to rotate. The connecting rod C 146  drives the clamp arm C 132  to open until the clamp arm C 132  is fully opened with respect to the adjusting portion C 120  and the supporting portion C 110 , so that the adaptive valve clamping device C 100  is in an opened state. After the clamping portion C 130  and the gripping portion C 150  cooperate and clamp the valve leaflets of the valve tissue, the driving shaft C 142  is driven by the mandrel to move toward the proximal end along the axial direction. The driving shaft C 142  drives the connecting rod C 146  to rotate, and the connecting rod C 146  drives the clamp arm C 132  to close until the clamp arm C 132  is completely closed with respect to the adjusting portion C 120  and the supporting portion C 110 , so that the adaptive valve clamping device C 100  is closed and falls below the valve. After that, the connection between the mandrel and the driving shaft C 142  may be released, the mandrel is withdrawn from the fixing part C 220 , and the locking nose C 222  is separated from the locking position C 1122  of the supporting portion C 110 , so as to disengage the adaptive valve clamping device C 100  from the delivery device C 200 . 
     Since the connecting position (i.e. disengagement position) between the adaptive valve clamping device C 100  and the delivery device C 200  is located in the adjusting portion C 120  of the adaptive valve clamping device C 100 , when the second end C 124  of the adjusting portion C 120  is provided with the opening C 128 , no part will hook the locking nose C 222  at the terminal end of the branch of the fixing part C 220  to facilitate the release of the adaptive valve clamping device C 100 . In addition, the disengagement position is provided inside the adjusting portion C 120 , which can reduce the axial size of the disengagement position, so as to reduce the weight of the whole adaptive valve clamping device C 100  and reduce the load on the heart; the disengagement position is not directly scoured by blood, which can avoid damage to the valve leaflet caused by repeated wear of the valve leaflet at the disengagement position and reduce the risk of thrombosis. 
     Referring to  FIG.  70    to  FIG.  74   , a use process of the adaptive valve clamping device C 100  of the present disclosure is described taking anterograde approach and repair of the mitral valve via the left atrium as an example: 
     Step 1: pushing the delivery device C 200  and the adaptive valve clamping device C 100  connected thereto from the left atrium LA to the left ventricle LV via the mitral valve MV by a guiding device (not shown) such as a bendable sheath, as shown in  FIG.  70   ; 
     Step 2: adjusting the adaptive valve clamping device C 100  to approach the anterior mitral leaflet AML and the posterior mitral leaflet PML of the mitral valve MV; 
     Step 3: unlocking the locking part C 141  in the third seat body C 116 , pushing the mandrel and the driving shaft C 142  to the distal end, driving the clamp arm C 132  to open with respect to the supporting portion C 110  and the adjusting portion C 120 , and adjusting the direction of the clamp arm C 132 , at which time a relative position of the clamp arm C 132  and the anterior mitral leaflet AML and the posterior mitral leaflet PML of the mitral valve MV can be observed by medical imaging equipment such as X-ray, so that the clamp arm C 132  is perpendicular to a coapting line of the mitral valve MV, as shown in  FIG.  71   ; 
     Step 4: withdrawing the entire adaptive valve clamping device C 100  to the proximal end to make the clamp arm C 132  hold the valve leaflet on the left ventricle LV side, and loosening the adjusting wire to release the gripping arms C 152  on both sides, wherein the gripping arm C 152  on each side presses the valve leaflet on the atrium side and cooperates with the clamp arm C 132  on the side to fix the valve leaflet to realize complete clamping of the valve leaflet, as shown in  FIG.  72   ; 
     Step 5: when the anterior mitral leaflet AML and the posterior mitral leaflet PML of the mitral valve MV are respectively clamped between a pair of clamp arms C 132  and a pair of gripping arms C 152 , pulling the mandrel and driving shaft C 142  to the proximal end to drive the clamp arm C 132  to close, as shown in  FIG.  73   ; 
     Step 6: releasing the threaded connection between the mandrel and the driving shaft C 142 , withdrawing the mandrel to release the connection between the adaptive valve clamping device C 100  and the delivery device C 200 , and then withdrawing the delivery device C 200  from the body, resulting in an implanted state as shown in  FIG.  74   , at which time the adaptive valve clamping device C 100  pulls the anterior mitral leaflet AML and the posterior mitral leaflet PML of the mitral valve MV toward each other to obtain a double-orifice mitral valve and complete edge-to-edge repair of the mitral valve. 
     After the adaptive valve clamping device C 100  is implanted, the elastic adjusting portion C 120  is filled between the anterior mitral leaflet AML and the posterior mitral leaflet PML of the clamped mitral valve MV and abuts against the clamp arm C 132 , so as to reduce the central regurgitation and improve the treatment effect. The self-expanding body C 121  (such as of mesh structure or porous structure) of the adjusting portion C 120  has a cushioning effect on the pulsating valve leaflets, so as to adjust the adaptivity to the pulling degree of the valve leaflets by the adaptive valve clamping device C 100  and avoid damaging the valve leaflets. The self-expanding body C 121  may be compressed and deformed following the pulsation of the valve leaflet, and the generated elastic force pushes the part of the valve leaflet close to the self-expanding body C 121  away from the supporting portion C 110 , so that the clamping angle between the anterior and posterior mitral leaflets of the mitral valve is less than the opening angle of the clamp arm C 132 , which can reduce pulling of the valve leaflet by the clamping portion C 130  and keep the pulling degree of the valve leaflet by the adaptive valve clamping device C 100  always within a reasonable range. In addition, when pressed by the valve leaflet, the adjusting portion C 120  will be deformed to a certain extent, and the deformation degree increases with the increase of pressure, so as to avoid the self-expanding body C 121  being extruded by the clamp arm C 132  and acting on the clamp arm C 132  in turn after the valve leaflet is gripped, and to ensure that the gripping effect of the adaptive valve clamping device C 100  on the valve leaflet after release is consistent with that before release. 
     Second Example 
     Referring to  FIG.  75    to  FIG.  78   , an adaptive valve clamping device of a second example of the present disclosure is different from the adaptive valve clamping device C 100  of the first example in structures of the first head C 426  of the adjusting portion C 420  and the second seat body C 414  of the supporting portion C 410 . 
     Specifically, the first head C 426  is movably sleeved outside the second seat body C 414  of the supporting portion C 410 , the inner cavity of the first head C 426  is provided with a first rotation stop C 4260 , the outer surface of the second seat body C 414  is provided with a second rotation stop C 4140  corresponding to the first rotation stop C 4260 , and the first rotation stop C 4260  is detachably fittingly connected to the second rotation stop C 4140 . In this way, the rotation of the adjusting portion C 420  around the axial direction is limited by providing the first rotation stop C 4260  and the second rotation stop C 4140  which are detachably fittingly connected to avoid the adjusting portion C 420  rotating with respect to the second seat body C 414 , resulting in reduction of the contact area between the adjusting portion C 420  and the valve leaflet and affecting the clamping effect on the valve leaflet. 
     Referring to  FIG.  75    to  FIG.  77   , the first rotation stop C 4260  comprises at least one plane surface C 4262  and/or at least one cambered surface C 4264 , and the second rotation stop C 4140  comprises at least one plane surface C 4142  and/or at least one cambered surface C 4144 . In the example of  FIG.  75   , the first rotation stop C 4260  comprises two opposite plane surfaces C 4262  and two opposite cambered surfaces C 4264 , that is, the inner cavity of the first head C 426  is provided with two opposite plane surfaces C 4262  and two opposite cambered surfaces C 4264 . Correspondingly, the second rotation stop C 4140  comprises two opposite plane surfaces C 4142  and two opposite cambered surfaces C 4144 , that is, the outer surface of the second seat body C 414  is provided with two opposite plane surfaces C 4142  and two opposite cambered surfaces C 4144 . During assembly, the plane surface C 4262  of the first head C 426  faces the plane surface C 4142  of the second seat body C 414 , and the cambered surface C 4264  of the first head C 426  faces the cambered surface C 4144  of the second seat body C 414 . In this way, the first head C 426  is sleeved outside the second seat body C 414 , which can ensure that the axial movement of the adjusting portion C 420  is not affected. Meanwhile, the two facing plane surfaces C 4142  of the second seat body C 414  and the first head C 426  can prevent the adjusting portion C 420  from rotating axially on the second seat body C 414 . The spacing between the two plane surfaces C 4262  of the first head C 426  should be at least 0.01 mm, preferably 0.02 mm to 1 mm larger than the spacing between the two plane surfaces C 4142  of the second seat body C 414 . The spacing between the two cambered surfaces C 4264  of the first head C 426  should be at least 0.01 mm, preferably 0.05 mm to 3 mm larger than the spacing between the two cambered surfaces C 4144  of the second seat body C 414 . In the example of  FIG.  76   , the first rotation stop C 4260  comprises one plane surface C 4262  and one cambered surface C 4264 , and the second rotation stop C 4140  comprises two plane surfaces C 4142  and one cambered surface C 4144 . In the example of  FIG.  77   , the second rotation stop C 4140  comprises three plane surfaces C 4142  and three cambered surfaces C 4144 . Preferably, the cambered surface may be a circular cambered surface. Certainly, alternatively, the first rotation stop C 4260  comprises one cambered surface C 4264 , and the second rotation stop C 4140  comprises a plurality of plane surfaces C 4142 , that is, the inner cavity surface of the first head C 426  is a circumferential cambered surface, and the cross-sectional contour of the outer surface of the second seat body C 414  is a polygon. 
     Certainly, the first rotation stop C 4260  and the second rotation stop C 4140  may be of a polyhedron structure fittingly connected. For example, both the first rotation stop C 4260  and the second rotation stop C 4140  are of a triangular prism structure, that is, the inner cavity of the first head C 426  is provided with three plane surfaces connected to each other, and the outer surface of the second seat body C 414  is correspondingly provided with three plane surfaces connected to each other. 
     Referring to  FIG.  78   , one of the first rotation stop C 4260  and the second rotation stop C 4140  is a sliding groove extending axially, and the other is a protrusion fitting in the sliding groove. The axial rotation of the adjusting portion C 420  is limited by fit between the sliding groove and the protrusion, and the axial movement of the adjusting portion C 420  is not affected. In the figure, the second seat body C 414  is provided with a sliding groove C 4146  extending along the axial direction, and the inner cavity of the first head C 426  is provided with a protrusion C 4266  protruded inward and movable along the sliding groove. Preferably, the second seat body C 414  is provided with two opposite sliding grooves C 4146 , and the first head C 426  is provided with two protrusions C 4266  protruded inward. Certainly, alternatively, the second seat body C 414  is provided with an outward protrusion, and the first head C 426  is provided with a sliding groove. 
     In other implementation modes, the second seat body C 414  may be provided with an outward protrusion, and the inner cavity of the first head C 426  may be provided with an inward protrusion. The protruding structures of the two fit and have a track guiding the movement, and can also prevent the adjusting portion C 420  from rotating along the supporting portion C 410 . 
     It should be noted that in the second example, the first head C 426  is integrally molded with the first rotation stop C 4260 , and the second seat body C 414  is integrally molded with the second rotation stop C 4140 . 
     Third Example 
     Referring to  FIG.  79    and  FIG.  80   , the difference between an adaptive valve clamping device of a third example and the adaptive valve clamping device of the second example in the present disclosure is that structures of the first head C 526  of the adjusting portion C 520  and the second seat body C 514  of the supporting portion C 510  are different. In the present example, the first head C 526  is connected to the first rotation stop C 5260 , and/or the second seat body C 524  is connected to the second rotation stop C 5140 . Specifically, the first head C 526  and the first rotation stop C 5260  can be fixed together by common detachable or non-detachable connection means such as welding, bonding, threaded connection, crimping, or bolt locking. The second seat body C 514  and the second rotation stop C 5140  can be fixed together by common detachable or non-detachable connection means such as welding, bonding, threaded connection, crimping, or bolt locking. The present example adopts welding connection. 
     It can be understood that the valve clamping system of the present disclosure comprises any one of the adaptive valve clamping devices described above and a delivery device capable of delivering the adaptive valve clamping device from outside the body to the vicinity of the mitral or tricuspid valve and clamping the valve leaflet. The above description of the valve clamping device is for purpose of example only and is not limitation of the present disclosure, and a valve clamping device and a valve clamping system comprising the valve clamping device obtained by one skilled in the art based upon the teachings of the present disclosure are within the scope of the present disclosure. 
     It should be noted that in this specification, relational terms such as “first” and “second” are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply that there is any such actual relationship or sequence among the entities or operations. Moreover, the terms “comprise”, “include” or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article, or device that comprises a series of elements comprises not only those elements, but also other elements that are not explicitly listed, or further comprises elements inherent to the process, method, article or device. Without more limitations, the element defined by the phrase “comprise a . . . ” does not exclude the existence of other same elements in the process, method, article, or device that comprises the element. 
     The above are only detailed description of the present disclosure to enable one skilled in the art to understand or implement the disclosure. Various modifications to these examples will be obvious to one skilled in the art, and the general principles defined herein can be implemented in other examples without departing from the spirit or scope of the present disclosure. Therefore, the present disclosure will not be limited to the examples shown in the present disclosure, but should conform to the widest scope consistent with the principles and novel characteristics of the present disclosure.