Patent Publication Number: US-2012039900-A1

Title: Biomarkers predictive of the responsiveness to tnfalpha inhibitors in autoimmune disorders

Description:
RELATED APPLICATIONS 
     This application is a continuation application of U.S. patent application Ser. No. 12/130,373, filed on May 30, 2008, which claims the benefit of priority to U.S. provisional patent application No. 60/932,888 filed on May 31, 2007. The contents of the above-mentioned priority application is hereby incorporated by reference in its entirety. 
    
    
     BACKGROUND OF THE INVENTION 
     Autoimmune disorders are a significant and widespread medical problem. For example, rheumatoid arthritis (RA) is an autoimmune disease affecting more than two million people in the United States. RA causes chronic inflammation of the joints and typically is a progressive illness that has the potential to cause joint destruction and functional disability. The cause of rheumatoid arthritis is unknown, although genetic predisposition, infectious agents and environmental factors have all been implicated in the etiology of the disease. In active RA, symptoms can include fatigue, lack of appetite, low grade fever, muscle and joint aches and stiffness. Also during disease flare ups, joints frequently become red, swollen, painful and tender, due to inflammation of the synovium. Furthermore, since RA is a systemic disease, inflammation can affect organs and areas of the body other than the joints, including glands of the eyes and mouth, the lung lining, the pericardium, and blood vessels. 
     Traditional treatments for the management of RA and other autoimmune disorders include fast acting “first line drugs” and slower acting “second line drugs.” The first line drugs reduce pain and inflammation. Example of such first line drugs include aspirin, naproxen, ibuprofen etodolac and other nonsteroidal anti-inflammatory drugs (NSAIDs), as well as corticosteroids, given orally or injected directly into tissues and joints. The second line drugs promote disease remission and prevent progressive joint destruction and are also referred to as disease-modifying anti-rheumatic drugs or DMARDs. Examples of second line drugs include gold, hydrochloroquine, azulfidine and immunosuppressive agents, such as methotrexate, azathioprine, cyclophosphamide, chlorambucil and cyclosporine. Many of these drugs, however, can have detrimental side-effects. Thus, additional therapies for rheumatoid arthritis and other autoimmune disorders have been sought. 
     More recently, biological therapies have been applied to the treatment of autoimmune disorders such as rheumatoid arthritis. For example, three TNFα inhibitors, REMICADE™ (infliximab), a chimeric anti-TNFα mAb, ENBREL™ (etanercept), a TNFR-Ig Fc fusion protein, and HUMIRA™ (adalimumab), a human anti-TNFα mAb, have been approved by the FDA for treatment of rheumatoid arthritis. While such biologic therapies have demonstrated success in the treatment of rheumatoid arthritis and other autoimmune disorders, not all subjects treated respond, or respond well, to a TNFα inhibitor. The use of TNFα inhibitors such as TNFα inhibitors typically is more expensive than traditional treatments and usually requires administration by injection, which, at least for certain agents, may require that the patient visit a medical office on a frequent basis. Thus, it would be very helpful to predict in advance of treatment whether a rheumatoid arthritis patient is likely to be responsive to treatment with a TNFα inhibitor. Accordingly, ways for predicting responsiveness to a TNFα inhibitor in patients having autoimmune disorders, such as rheumatoid arthritis patients, are of particular interest. 
     SUMMARY OF THE INVENTION 
     This invention provides methods and compositions for predicting responsiveness to a TNFα inhibitor in a subject having an autoimmune disorder, such as rheumatoid arthritis, based on the discovery that the expression patterns of particular biomarkers in the subject correlate with responsiveness to a TNFα inhibitor. Using microarray analysis of monocytes from representative rheumatoid arthritis (RA) patients treated with an anti-TNFα monoclonal antibody, 82 differentially expressed genes predictive of responsiveness to TNFα inhibitor treatment were identified by pairwise comparisons between future RA responders and future RA non-responders to anti-TNFα therapy. Furthermore, hierarchical clustering and TaqMan®-PCR of RA responders/non-responders pre-treatment identified one gene of particular interest, CD11c, which was fully predictive of future response to anti-TNFα treatment. 
     Accordingly, in one aspect, the invention pertains to a method for predicting responsiveness to a TNFα inhibitor in a subject having an autoimmune disorder (e.g., rheumatoid arthritis). The method comprises: (i) assaying the subject for expression of one or more biomarkers predictive of responsiveness to a TNFα inhibitor in an autoimmune disorder, and (ii) predicting responsiveness of the subject to the TNFα inhibitor based on expression of the one or more biomarkers in the subject, wherein the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-82 (corresponding to the sequences set forth in Table 9) 
     Within SEQ ID NOs: 1-82, certain genes were found to be upregulated in RA responders to TNFα inhibitors. Accordingly, in one embodiment, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 6, 7, 10, 15-17, 19, 22, 24, 27, 31, 34-39, 43-47, 49, 51, 54, 55, 57, 59, 61, 62, 64, 70, 75, 79 and 82 (corresponding to sequences from Table 9 that are increased in ≧80% of responders vs. non-responders). More preferably, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 31, 37, 44, 47, 62 and 70 (corresponding to sequences from Table 9 that are increased in ≧90% of responders vs. non-responders). Even more preferably, the one or more biomarkers is encoded by a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO: 44. (corresponding to CD11c, from Table 9, which is increased in 100% of responders vs. non-responders). In each of these embodiments, increased expression of the one or more biomarkers is predictive of responsiveness of the subject to a TNFα inhibitor. 
     Within SEQ ID NOs: 1-82, certain genes were found to be downregulated in RA responders to TNFα inhibitors. Accordingly, in one embodiment, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 1-5, 8, 9, 11-14, 18, 20, 21, 23, 25, 26, 28-30, 32, 33, 40-42, 48, 50, 52, 53, 56, 58, 60, 63, 65-69, 71-74, 76-78, 80 and 81. (corresponding to sequences from Table 9 that are decreased in ≧80% of responders vs. non-responders). More preferably, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 11, 29, 65, 73 and 74 (corresponding to sequences from Table 9 that are decreased in ≧90% of responders vs. non-responders). Even more preferably, the one or more biomarkers is encoded by a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO: 11 or SEQ ID NO: 74 (corresponding to sequences from Table 9 that are decreased in 100% of responders vs. non-responders). In each of these embodiments, decreased expression of the one or more biomarkers is predictive of responsiveness of the subject to a TNFα inhibitor. 
     In another aspect, the invention provides a method for predicting responsiveness to a TNFα inhibitor in a subject having an autoimmune disorder, the method comprising: (i) assaying the subject for expression of one or more biomarkers predictive of responsiveness to a TNFα inhibitor in an autoimmune disorder, and (ii) predicting responsiveness of the subject to the TNFα inhibitor based on expression of the one or more biomarkers in the subject, wherein the one or more biomarkers is selected from the group consisting of Aquaporin 3 (Genbank Accession No. NM — 004925); Similar to ribosomal protein S24, clone MGC:8595 (Genbank Accession No. NM — 033022); Transmembrane emp24 domain trafficking protein 2 (Genbank Accession No. NM — 006815; Superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (Genbank Accession No. NM — 000454); Calmodulin 1 (phosphorylase kinase, delta) (Genbank Accession No. NM — 006888); Guanine nucleotide binding protein (G protein), beta polypeptide 1 (Genbank Accession No. NM — 002074); Prothymosin, alpha (gene sequence 28) (Genbank Accession No. NM — 002823);  Homo sapiens  isocitrate dehydrogenase 1 (NADP+) soluble (IDH1) (Genbank Accession No. NM — 005896); Tumor protein D52 (Genbank Accession Nos. NM — 001025252, NM — 001025253, NM — 005079); Early growth response 1 (Genbank Accession No. NM — 001964);  Homo sapiens  predicted osteoblast protein (GS3786) (Genbank Accession Nos. NM — 014888, NM — 001040020); Cytochrome c oxidase subunit VIIb (Genbank Accession No. NM — 001866); CUG triplet repeat, RNA binding protein 2 (Genbank Accession No. NM — 001025077, NM — 001025076, NM — 006561); Ubiquinol-cytochrome c reductase hinge protein (Genbank Accession No. NM — 006004);  Homo sapiens  leptin receptor gene-related protein (HS0BRGRP) (Genbank Accession No. NM — 017526); Wiskott-Aldrich syndrome protein interacting protein (Genbank Accession Nos. NM — 001077269, NM — 003387); CD97 antigen (Genbank Accession Nos. NM — 001025160, NM — 001784, NM — 078481); Glutamate-cysteine ligase, catalytic subunit (Genbank Accession No. NM — 001498); Crystallin, zeta (quinone reductase) (Genbank Accession No. NM — 001889); Rap guanine nucleotide exchange factor (GEF) 2 (Genbank Accession No. NM — 014247); Ataxin 1 (Genbank Accession No. NM — 000332); Adaptor-related protein complex 1, sigma 2 subunit (Genbank Accession No. NM — 003916); Ectonucleotide pyrophosphatase/phosphodiesterase 4 (Genbank Accession No. NM — 014936); Desmocollin 2 (Genbank Accession Nos. NM — 024422, NM — 004949); MAL, T-cell differentiation protein (Genbank Accession Nos. NM — 002371, NM — 022438, NM — 022439, NM — 022440); Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (Genbank Accession No. NM — 005476); Chemokine (C—C motif) ligand 3 (Genbank Accession Nos. NM — 001001437, NM — 021006); Carboxypeptidase A3 (Genbank Accession No. NM — 001870); Charcot-Leyden crystal protein (Genbank Accession No. NM — 001828); NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7 kDa (Genbank Accession No. NM — 004545); Interleukin 8 receptor, beta (Genbank Accession No. NM — 001557); Platelet factor 4 variant 1 (Genbank Accession No. NM — 002620); Poly(A) binding protein interacting protein 1 (Genbank Accession No. NM — 006451); ATP-binding cassette, sub-family C (CFTR/MRP), member 3 (Genbank Accession No. NM — 003786); Actinin, alpha 1 (Genbank Accession No. NM — 001102); NAD kinase (Genbank Accession No. NM — 023018); Platelet/endothelial cell adhesion molecule (CD31 antigen) (Genbank Accession No. NM — 000442); Esterase D/formylglutathione hydrolase (Genbank Accession No. NM — 001984); Chromosome 20 open reading frame 111 (Genbank Accession No. NM — 016470); Sterol-C4-methyl oxidase-like (Genbank Accession Nos. NM — 001017369, NM — 006745); PIM-1 oncogene (Genbank Accession No. NM — 002648); GATA binding protein 2 (Genbank Accession No. NM — 032638); Cathepsin Z (Genbank Accession No. NM — 001336); Integrin alpha-X (antigen CD11c) (Genbank Accession No. NM — 000887); Lectin, galactoside-binding, soluble, 8 (galectin 8) (Genbank Accession Nos. NM — 006499, NM — 201545); CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) (Genbank Accession Nos. NM — 006889, NM — 175862); Interleukin 8 (Genbank Accession No. NM — 000584); Fc fragment of IgE, high affinity I, receptor for alpha polypeptide (Genbank Accession No. NM — 002001); Actin, gamma 1 (Genbank Accession No. NM — 001614); KIAA0746 protein (Genbank Accession No. NM — 015187); Glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) (Genbank Accession No. NM — 002076); Transcription factor 4 (Genbank Accession Nos. BF592782, CR612521); Major histocompatibility complex, class II, DQ alpha 1 (Genbank Accession Nos. NM — 002122, NM — 020056); Cell division cycle 2-like 6 (CDK8-like) (Genbank Accession No. NM — 015076); Major histocompatibility complex, class II, DQ beta 1 (Genbank Accession No. XM — 942240); Phospholipase C-like 2 (Genbank Accession No. NM — 015184); Coagulation factor II (thrombin) receptor-like 1 (Genbank Accession No. NM — 005242); TM2 domain containing 1 (Genbank Accession No. NM — 032027); Splicing factor 3b, subunit 1, 155 kDa (Genbank Accession No. NM — 012433); SUB1 homolog ( S. cerevisiae ) (Genbank Accession No. NM — 006713); MRNA; cDNA DKFZp564O0862 (Genbank Accession No. AI278204); Amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) (Genbank Accession Nos. NM — 201413, NM — 000484, NM — 201414); Cytochrome b-5 (Genbank Accession Nos. NM — 001914, NM — 148923); Cold autoinflammatory syndrome 1 (Genbank Accession No. NM — 183395); Neugrin, neurite outgrowth associated (Genbank Accession Nos. NM — 016645, NM — 001033088); Ribosomal protein S26, 40S ribosomal protein (Genbank Accession No. XM — 941927); CCR4-NOT transcription complex, subunit 6 (Genbank Accession No. NM — 015455); Ubiquinol-cytochrome c reductase complex (7.2 kD) (Genbank Accession Nos. NM — 013387, NM — 001003684); Hepatocellular carcinoma-associated antigen 112 (Genbank Accession No. NM — 018487); Kruppel-like factor 11 (Genbank Accession No. XM — 001129527); GGA binding partner (Genbank Accession No. NM — 018318); Cornichon homolog 4 (Drosophila) (Genbank Accession No. NM — 014184); Hypothetical protein FLJ21616 (Genbank Accession No. NM — 024567);  Homo sapiens  hypothetical protein FLJ10134 (Genbank Accession No. NM — 018004); Nuclear prelamin A recognition factor (Genbank Accession Nos. NM — 012336, NM — 001038618); Erythroblast membrane-associated protein (Genbank Accession Nos. NM — 018538, NM — 001017922); LR8 protein (Genbank Accession No. NM — 014020); Likely ortholog of mouse limb-bud and heart gene (LBH) (Genbank Accession No. NM — 030915); Calmin (calponin-like, transmembrane) (Genbank Accession No. NM — 024734); Chromosome 14 open reading frame 156 (Genbank Accession No. NM — 031210); Guanine nucleotide binding protein (G protein) alpha 12 (Genbank Accession No. NM — 007353); and SRY (sex determining region Y)-box 18 (Genbank Accession No. NR — 003287) (corresponding to biomarkers listed in Table 9). 
     Within the above-listed biomarkers, certain genes were found to be upregulated in RA responders to TNFα inhibitors. Accordingly, in one embodiment, the one or more biomarkers is selected from the group consisting of Guanine nucleotide binding protein (G protein), beta polypeptide 1; Prothymosin, alpha (gene sequence 28); Early growth response 1;  Homo spaiens  leptin receptor gene-related protein (HS0BRGRP); Wiskott-Aldrich syndrome protein interacting protein; CD97 antigen; Crystallin, zeta (quinone reductase); Adaptor-related protein complex 1, sigma 2 subunit; Desmocollin 2; Chemokine (C—C motif) ligand 3; Interleukin 8 receptor, beta; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; Actinin, alpha 1; NAD kinase; Platelet/endothelial cell adhesion molecule (CD31 antigen); Esterase D/formylglutathione hydrolase; Chromosome 20 open reading frame 111; Cathepsin Z; Integrin alpha-X (antigen CD11c); Lectin, galactoside-binding, soluble, 8 (galectin 8); CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); Interleukin 8; Actin, gamma 1; Glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID); Cell division cycle 2-like 6 (CDK8-like); Major histocompatibility complex, class II, DQ beta 1; Coagulation factor II (thrombin) receptor-like 1; Splicing factor 3b, subunit 1, 155 kDa; mRNA; cDNA DKEZp564O0862; Amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); Cold autoinflammatory syndrome 1; Kruppel-like factor 11; Nuclear prelamin A recognition factor; Calmin (calponin-like, transmembrane); and SRY (sex determining region Y)-box 18 (corresponding to biomarkers from Table 9 that are increased in ≧80% of responders vs. non-responders). More preferably, the one or more biomarkers is selected from the group consisting of Interleukin 8 receptor, beta; Platelet/endothelial cell adhesion molecule (CD31 antigen); Integrin alpha-X (antigen CD11c); Interleukin 8; Amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); and Kruppel-like factor 11 (corresponding to biomarkers from Table 9 that are decreased in ≧80% of responders vs. non-responders). Even more preferably, the one or more biomarkers is Integrin alpha-X (antigen CD11c) (corresponding to a biomarker from Table 9 that is increased in 100% of responders vs. non-responders). In each of these embodiments, increased expression of the one or more biomarkers is predictive of responsiveness of the subject to a TNFα inhibitor. 
     Within the above-listed biomarkers, certain genes were found to be downregulated in RA responders to TNFα inhibitors. Accordingly, in one embodiment, the one or more biomarkers is selected from the group consisting of Aquaporin 3; Similar to ribosomal protein S24, clone MGC:8595; Transmembrane emp24 domain trafficking protein 2; Superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1; Calmodulin 1 (phosphorylase kinase, delta);  Homo sapiens  isocitrate dehydrogenase 1 (NADP+) soluble (IDH1); Tumor protein D52;  Homo sapiens  predicted osteoblast protein (GS3786); Cytochrome c oxidase subunit VIIb; CUG triplet repeat, RNA binding protein 2; Ubiquinol-cytochrome c reductase hinge protein; Glutamate-cysteine ligase, catalytic subunit; Rap guanine nucleotide exchange factor (GEF) 2; Ataxin 1; Ectonucleotide pyrophosphatase/phosphodiesterase 4; MAL, T-cell differentiation protein; Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase; Carboxypeptidase A3; Charcot-Leyden crystal protein; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7 kDa; Platelet factor 4 variant 1; Poly(A) binding protein interacting protein 1; Sterol-C4-methyl oxidase-like; PIM-1 oncogene; GATA binding protein 2; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; KIAA0746 protein; Transcription factor 4; Major histocompatibility complex, class II, DQ alpha 1; Phospholipase C-like 2; TM2 domain containing 1; SUB1 homolog ( S. cerevisiae ); Cytochrome b-5; Neugrin, neurite outgrowth associated; Ribosomal protein S26, 40S ribosomal protein; CCR4-NOT transcription complex, subunit 6; Ubiquinol-cytochrome c reductase complex (7.2 kD); Hepatocellular carcinoma-associated antigen 112; GGA binding partner; Cornichon homolog 4 (Drosophila); Hypothetical protein FLJ21616;  Homo sapiens  hypothetical protein FLJ10134; Erythroblast membrane-associated protein; LR8 protein; Likely ortholog of mouse limb-bud and heart gene (LBH); Chromosome 14 open reading frame 156; and Guanine nucleotide binding protein (G protein) alpha 12 (corresponding to biomarkers from Table 9 that are decreased in ≧80% of responders vs. non-responders). More preferably, the one or more biomarkers is selected from the group consisting of  Homo sapiens  predicted osteoblast protein (GS3786); Charcot-Leyden crystal protein; Neugrin, neurite outgrowth associated; Hypothetical protein FLJ21616; and  Homo sapiens  hypothetical protein FLJ10134 (corresponding to biomarkers from Table 9 that are decreased in ≧90% of responders vs. non-responders). Even more preferably, the one or more biomarkers is  Homo sapiens  predicted osteoblast protein (GS3786) or  Homo sapiens  hypothetical protein FLJ10134 (corresponding to biomarkers from Table 9 that are decreased in 100% of responders vs. non-responders). In each of these embodiments, decreased expression of the one or more biomarkers is predictive of responsiveness of the subject to a TNFα inhibitor. 
     In yet another aspect, the invention provides a method for predicting responsiveness to a TNFα inhibitor in a subject having an autoimmune disorder, the method comprising: (i) assaying the subject for increased expression of a biomarker, which biomarker is CD11c, and (ii) predicting responsiveness of the subject to the TNFα inhibitor based on increased expression of CD11c in the subject. 
     In yet another aspect, the invention provides a method for predicting responsiveness to a TNFα inhibitor, which TNFα inhibitor is adalimumab, in a subject having an autoimmune disorder, the method comprising: (i) assaying the subject for expression of one or more biomarkers predictive of responsiveness to adalimumab in an autoimmune disorder, and (ii) predicting responsiveness of the subject to adalimumab based on expression of the one or more biomarkers in the subject. Preferably, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-82 (corresponding to biomarkers set forth in Table 9). 
     In one embodiment of the methods of the invention, a sample from the subject is assayed for expression of mRNA encoding the one or more biomarkers. In another embodiment of the methods of the invention, a sample from the subject is assayed for protein expression of the one or more biomarkers. 
     In one embodiment, the methods of the invention further comprise selecting a treatment regimen with the TNFα inhibitor based upon expression of the one or more biomarkers in the subject. In another embodiment, the methods of the invention further comprise administering the TNFα inhibitor to the subject according to the treatment regimen such that autoimmune disorder is inhibited in the subject. 
     A preferred TNFα inhibitor of the invention is an anti-tumor necrosis factor-alpha (TNFα) antibody, or antigen-binding portion thereof. The anti-TNFα antibody, or antigen-binding portion thereof, can be, for example, a humanized antibody, a chimeric antibody or a multivalent antibody. For example, the anti-TNFα antibody, or antigen-binding portion thereof, can be infliximab or golimumab. In another embodiment, the anti-TNFα antibody, or antigen-binding portion thereof, is a human antibody. For example, the anti-TNFα antibody, or antigen-binding portion thereof, can be an isolated human antibody that dissociates from human TNFα with a K d  of 1×10 −8  M or less and a K off  rate constant of 1×10 −3  s −1  or less, both determined by surface plasmon resonance, and neutralizes human TNFα cytotoxicity in a standard in vitro L929 assay with an IC 50  of 1×10 −7  M or less. In another embodiment, the anti-TNFα antibody, or antigen-binding portion thereof, is an isolated human antibody with the following characteristics: 
     a) dissociates from human TNFα with a K off  rate constant of 1×10 −3  s −1  or less, as determined by surface plasmon resonance; 
     b) has a light chain CDR3 domain comprising the amino acid sequence of SEQ ID NO: 305, or modified from SEQ ID NO: 305 by a single alanine substitution at position 1, 4, 5, 7 or 8 or by one to five conservative amino acid substitutions at positions 1, 3, 4, 6, 7, 8 and/or 9; 
     c) has a heavy chain CDR3 domain comprising the amino acid sequence of SEQ ID NO: 306, or modified from SEQ ID NO: 306 by a single alanine substitution at position 2, 3, 4, 5, 6, 8, 9, 10 or 11 or by one to five conservative amino acid substitutions at positions 2, 3, 4, 5, 6, 8, 9, 10, 11 and/or 12. 
     In another embodiment, the anti-TNFα antibody, or antigen-binding portion thereof, is an isolated human antibody with a light chain variable region (LCVR) comprising the amino acid sequence of SEQ ID NO: 303 and a heavy chain variable region (HCVR) comprising the amino acid sequence of SEQ ID NO: 304. In yet another embodiment, the anti-TNFα antibody, or antigen-binding portion thereof, is adalimumab. Yet another example of a TNFα inhibitor is etanercept. 
     Preferably, in the methods of the invention, the subject is a human. 
     In another aspect, the invention pertains to a kit for predicting responsiveness to a TNFα inhibitor in a subject having an autoimmune disorder (e.g., rheumatoid arthritis). The kit comprises: 
     a) means for isolating monocytes; 
     b) means for measuring expression in the subject of one or more biomarkers predictive of responsiveness to a TNFα inhibitor in an autoimmune disorder; 
     c) means for measuring expression of at least one housekeeping gene; and 
     d) instructions for use of the kit to predicting responsiveness to a TNFα inhibitor in a subject having an autoimmune disorder, wherein the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-82. 
     In one embodiment of the kit, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 6, 7, 10, 15-17, 19, 22, 24, 27, 31, 34-39, 43-47, 49, 51, 54, 55, 57, 59, 61, 62, 64, 70, 75, 79 and 82, more preferably the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 31, 37, 44, 47, 62 and 70, even more preferably the one or more biomarkers is encoded by a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO: 44 (CD11c). In each of these embodiments, the instructions for use of the kit instruct that increased expression of the one or more biomarkers is predictive of responsiveness of the subject to a TNFα inhibitor. 
     In another embodiment of the kit, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 1-5, 8, 9, 11-14, 18, 20, 21, 23, 25, 26, 28-30, 32, 33, 40-42, 48, 50, 52, 53, 56, 58, 60, 63, 65-69, 71-74, 76-78, 80 and 81, more preferably the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 11, 29, 65, 73 and 74, even more preferably the one or more biomarkers is encoded by a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO: 11 or SEQ ID NO: 74. In each of these embodiments, the instructions for use of the kit instruct that decreased expression of the one or more biomarkers is predictive of responsiveness of the subject to a TNFα inhibitor. 
     In one embodiment of the kit, the means for measuring expression in the subject of one or more biomarkers predictive of responsiveness to a TNFα inhibitor in an autoimmune disorder comprises a nucleic acid preparation sufficient to detect expression of mRNA encoding the biomarker in a sample from the subject. In another embodiment of the kit, the means for measuring expression in the subject of one or more biomarkers predictive of responsiveness to a TNFα inhibitor in an autoimmune disorder comprises an antibody preparation sufficient to detect protein expression of the biomarker in a sample from the subject. The kit can further comprise a TNFα inhibitor for treating the autoimmune disorder in the subject. 
     In another aspect, the invention pertains to methods of monitoring an autoimmune disorder (e.g., RA) in a subject having the autoimmune disorder (e.g., RA). These methods are based, at least in part, on microarray analysis of monocytes from representative rheumatoid arthritis (RA) patients treated with an anti-TNFα monoclonal antibody, including (i) hierarchical clustering with the genes resulting from a simultaneous comparison between RA versus ND and RA responders pre- versus post-anti-TNFα therapy, (ii) prediction analysis of microarrays (PAM); and (iii) hierarchical clustering based on the comparison between RA responders and non-responders post-treatment. 
     Accordingly, in another aspect, the invention provides a method of monitoring an autoimmune disorder in a subject having the autoimmune disorder, the method comprising: assaying the subject for expression of one or more biomarkers, wherein the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 83-133 (corresponding to biomarkers set forth in Table 3), thereby monitoring the autoimmune disorder in the subject. 
     In another aspect, the invention provides a method of monitoring an autoimmune disorder in a subject having the autoimmune disorder, the method comprising: assaying the subject for expression of one or more biomarkers, wherein the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 134-177, 110, 112, 118, 123 and 131 (corresponding to biomarkers set forth in Table 4), thereby monitoring the autoimmune disorder in the subject. In one embodiment, preferably the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 134-150, 112, 118 and 131 (upregulated biomarkers from Table 4), wherein expression of the one or more biomarkers is increased in the subject. In another embodiment, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 151-177, 110 and 123 (downregulated biomarkers from Table 4), wherein expression of the one or more biomarkers is decreased in the subject. 
     In another aspect, the invention provides a method of monitoring an autoimmune disorder in a subject having the autoimmune disorder, the method comprising: assaying the subject for expression of one or more biomarkers, wherein the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 178-292, 91 and 97 (corresponding to biomarkers set forth in Table 5), thereby monitoring the autoimmune disorder in the subject. In one embodiment, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 178-185; 187-200, 202, 203, 205-207; 211, 213, 214, 216, 220, 221, 226, 228, 229, 231, 232, 234, 235, 238-247, 249, 250, 253, 262-265, 268-282 and 285-288 (upregulated biomarkers from Table 5), wherein expression of the one or more biomarkers is increased in the subject. In another embodiment, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 186, 201, 204, 208, 209, 91, 210, 212, 97, 215, 217-219, 222-225, 227, 230, 233, 236, 237, 248, 251, 252, 254-261, 266, 267, 283, 284 and 289-292 (downregulated biomarkers from Table 5), wherein expression of the one or more biomarkers is decreased in the subject. 
     In another aspect, the invention provides a method of monitoring an autoimmune disorder in a subject having the autoimmune disorder, the method comprising: assaying the subject for expression of one or more biomarkers, wherein the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 87, 97, 101, 293, 92, 272, 93, 107, 108, 121 and 123 (corresponding to pre-treatment biomarkers set forth in Table 6), and wherein the subject is monitored prior to treatment with a TNFα inhibitor, thereby monitoring the autoimmune disorder in the subject. 
     In another aspect, the invention provides a method of monitoring an autoimmune disorder in a subject having the autoimmune disorder the method comprising: assaying the subject for expression of one or more biomarkers, wherein the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 290, 209, 98, 112, 116, 121, 130, 155, 92, 289, 216 and 131 (corresponding to post-treatment biomarkers set forth in Table 6), and wherein the subject is monitored after treatment with a TNFα inhibitor, thereby monitoring the autoimmune disorder in the subject. 
     In yet another aspect, the invention provides a method of monitoring an autoimmune disorder in a subject having the autoimmune disorder, the method comprising: assaying the subject for expression of one or more biomarkers, wherein the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 97, 102, 29, 294, 295, 91, 131, 290, 100, 134, 296, 297, 298, 299, 136, 174 and 300 (corresponding to biomarkers set forth in Table 7), thereby monitoring the autoimmune disorder in the subject. 
     In yet another aspect, the invention pertains to a method of building a database for use in selecting a subject having an autoimmune disorder (e.g., RA) for treatment with a TNFα inhibitor. The method comprises: receiving, in a computer system, biomarker expression patterns from a plurality of subjects having an autoimmune disorder; and storing the biomarker expression pattern from each subject such that the biomarker expression pattern is associated with an identifier of the subject, wherein the biomarker expression pattern reports expression in the subject of one or more biomarkers encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-82. The identifier of the subject can be, for example, a numerical identifier coded to an identity of the subject. In a preferred embodiment, the method further comprises receiving, in the computer system, one or more treatment regimens for treatment of the autoimmune disorder in a subject such that the treatment regimen is associated with the biomarker expression pattern of the subject and the identifier of the subject. 
     The invention also pertains to a computer program product containing executable instructions that when executed cause a processor to perform operations comprising: receiving, in a computer system, a biomarker expression pattern of a subject at one or more biomarkers predictive of responsiveness to a TNFα inhibitor in an autoimmune disorder; and storing the biomarker expression pattern such that the biomarker expression pattern is associated with an identifier of the subject, wherein the biomarker expression pattern reports expression in the subject of one or more biomarkers encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-82. The computer program can further cause the processor to perform an operation comprising: receiving, in the computer system, a treatment regimen for treatment of the autoimmune disorder in the subject such that the treatment regimen is associated with the biomarker expression pattern of the subject and the identifier of the subject. 
     In yet another aspect, the invention pertains to a method of selecting an autoimmune disorder subject for treatment with a TNFα inhibitor, the method comprising: (i) identifying, in a database comprising a plurality of autoimmune disorder subjects, a subject whose database entry is associated with a biomarker expression pattern that is predictive of responsiveness to treatment with a TNFα inhibitor, and (ii) selecting the subject for treatment with a TNFα inhibitor, wherein the biomarker expression pattern reports expression in the subject of one or more biomarkers encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-82. The method can further comprise selecting a treatment regimen by identifying, in the database, a treatment regimen that has been associated with the biomarker expression pattern of the subject and with an identifier of the subject. 
     The invention also pertains to a computer program product containing executable instructions that when executed cause a processor to perform operations comprising: (i) identifying, in a database including a plurality of autoimmune disorder subjects associated with biomarker expression patterns, a subject that is associated with a biomarker expression pattern that is predictive of responsiveness to treatment with a TNFα inhibitor; and (ii) outputting the identified subject as a subject to be treated with a TNFα inhibitor; wherein the biomarker expression pattern reports expression in the subject of one or more biomarkers encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-82. In one embodiment, the computer program further causes the processor to perform an operation comprising outputting a treatment regimen that is associated with the subject to be treated with the TNFα inhibitor. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  is a bar graph showing the results of experiments validating the predictive gene CD11c by quantitative real-time PCR. mRNA expression was compared in monocytes from normal donors (n=16), as well as future responders and future non-responders to therapy with anti-TNFα (RA-ATNF; filled circles ; 15 responders and 12 non-responders) or to combination therapy with anti-TNFα/methotrexate (RA-αTNF/MTX; empty circles ∘; 7 responders and 9 non-responders) The expression of CD11c is expressed as the means±standard error of the mean normalized to that of the house keeping gene glycerol-aldehyd-3-phosphate dehydrogenase (GAPDH; % expression). Except for 1 RA patient with a borderline ACR response of 30 and a CD11c mRNA level directly at the distinction threshold (who was therefore classified as a false negative), the threshold level (40%) almost fully distinguished future responders from nonresponders (100% specificity, 94% sensitivity, and 96% power). The threshold level to distinguish future responders from non-responders is indicated by a broken line (----); * P≦0.05, ** P≦0.01 as compared to normal donors; +++ P≦0.005 as compared to future responders to anti-TNFα therapy. 
         FIG. 2  is a graph showing the correlation between the mRNA expression of predictive CD11c in pre-treatment RA patients and their individual future ACR response (continuous ACR score). The horizontal and vertical broken lines indicate the thresholds for the separation between RA-responders and RA-non-responders, both in terms of the pre-treatment CD11c mRNA levels (40%) and their ACR response (continuous ACR score ≦30). Responders (continuous American College of Rheumatology [ACR] score ≧40; clustered as ND) and non-responders to anti-TNF therapy (continuous ACR score ≦30; clustered as RA) were defined according to the criteria of the ACR. 
         FIG. 3  is a graph showing the correlation between the mRNA expression of predictive CD11c in pre-treatment RA patients and their individual future strict ACR response in the following conventional used steps: ≧0%, ≧20%, ≧50%, and ≧70% (continuous ACR score). 
     
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     This invention provides methods for predicting responsiveness to a TNFα inhibitor in a subject suffering from an autoimmune disorder, and methods for selecting a treatment regimen with a TNFα inhibitor, based on expression of particular biomarkers in the subject to be treated. The invention is based, at least in part, on the observation that altered expression of particular biomarkers in a subject suffering from rheumatoid arthritis is associated with increased or decreased responsiveness to therapy with a TNFα inhibitor. Microarray analysis, hierarchical clustering and TaqMan®-PCR analysis were used to examine normal donors (NA) and rheumatoid arthritis (RA) patients, who were categorized as being responsive to treatment with an anti-TNFα antibody (RA responders) or nonresponsive to treatment with an anti-TNFα antibody (RA nonresponders). A panel of 82 genes were identified whose expression was altered (upregulated or downregulated) in patients identified as either future RA responders or future RA nonresponders, demonstrating the ability of these genes to act as biomarkers for predicting responsiveness to TNFα inhibitor treatment. In particular, one gene, encoding the antigen CD11c, was identified as fully predicting the future response to anti-TNFα treatment. Accordingly, the expression pattern of one or more biomarkers can be assessed in RA subjects for which TNFα inhibitor therapy is being considered, or subjects suffering from other autoimmune disorders amenable to TNFα inhibitor therapy, to thereby predict responsiveness of the subject to such therapy and/or to aid in the selection of an appropriate treatment regimen. 
     Furthermore, additional patterns of biomarker expression were identified by (i) hierarchical clustering with the genes resulting from a simultaneous comparison between RA versus ND and RA responders pre- versus post-anti-TNFα therapy; (ii) prediction analysis of microarrays; and (iii) hierarchical clustering based on the comparison between RA responders and non-responders post-treatment. Accordingly, the biomarker expression patterns described herein also can be using in monitoring an autoimmune disorder in a subject, e.g., monitoring the responsiveness of the subject to a particular therapy or assisting in the diagnosis or prognosis of the autoimmune disorder (e.g., RA) in the subject. 
     In order that the present invention may be more readily understood, certain terms are first defined. Additional definitions are set forth throughout the detailed description. 
     The term “predicting responsiveness to a TNFα inhibitor”, as used herein, is intended to refer to an ability to assess the likelihood that treatment of a subject with a TNFα inhibitor will or will not be effective in (e.g., provide a measurable benefit to) the subject. In particular, such an ability to assess the likelihood that treatment will or will not be effective typically is exercised before treatment with the TNFα inhibitor is begun in the subject. However, it is also possible that such an ability to assess the likelihood that treatment will or will not be effective can be exercised after treatment has begun but before an indicator of effectiveness (e.g., an indicator of measurable benefit) has been observed in the subject. 
     The term “TNFα inhibitor” as used herein is intended to encompass agents including proteins, antibodies, antibody fragments, fusion proteins (e.g., Ig fusion proteins or Fc fusion proteins), multivalent binding proteins (e.g., DVD Ig), small molecule TNFα antagonists and similar naturally- or nonnaturally-occurring molecules, and/or recombinant and/or engineered forms thereof, that, directly or indirectly, inhibits TNFα activity, such as by inhibiting interaction of TNFα with a cell surface receptor for TNFα, inhibiting TNFα protein production, inhibiting TNFα gene expression, inhibiting TNFα secretion from cells, inhibiting TNFα receptor signaling or any other means resulting in decreased TNFα activity in a subject. The term “TNFα inhibitor” also includes agents which interfere with TNFα activity. Examples of TNFα inhibitors include etanercept (ENBREL™, Amgen), infliximab (REMICADE™, Johnson and Johnson), human anti-TNF monoclonal antibody adalimumab (D2E7/HUMIRA™, Abbott Laboratories), CDP 571 (Celltech), and CDP 870 (Celltech), as well as other compounds which inhibit TNFα activity, such that when administered to a subject suffering from or at risk of suffering from a disorder in which TNFα activity is detrimental (e.g., RA), the disorder is treated. The term also includes each of the anti-TNFα human antibodies and antibody portions described herein as well as those described in U.S. Pat. Nos. 6,090,382; 6,258,562; 6,509,015, and in U.S. patent application Ser. Nos. 09/801,185 (U.S. Publication No. 20030092059) and 10/302,356 (U.S. Publication No. 20030219438), each incorporated by reference herein. 
     The term “antibody” as referred to herein includes whole antibodies and any antigen binding fragment (i.e., “antigen-binding portion”) or single chains thereof. An “antibody” refers to a glycoprotein comprising at least two heavy (H) chains and two light (L) chains inter-connected by disulfide bonds, or an antigen binding portion thereof. Each heavy chain is comprised of a heavy chain variable region (abbreviated herein as V H ) and a heavy chain constant region. The heavy chain constant region is comprised of three domains, C H1 , C H2  and C H3 . Each light chain is comprised of a light chain variable region (abbreviated herein as V L ) and a light chain constant region. The light chain constant region is comprised of one domain, C L . The V H  and V L  regions can be further subdivided into regions of hypervariability, termed complementarity determining regions (CDR), interspersed with regions that are more conserved, termed framework regions (FR). Each V H  and V L  is composed of three CDRs and four FRs, arranged from amino-terminus to carboxy-terminus in the following order: FR1, CDR1, FR2, CDR2, FR3, CDR3, FR4. The variable regions of the heavy and light chains contain a binding domain that interacts with an antigen. The constant regions of the antibodies may mediate the binding of the immunoglobulin to host tissues or factors, including various cells of the immune system (e.g., effector cells) and the first component (Clq) of the classical complement system. 
     The term “antibody” is also intended to encompass dual-specific antibodies and bispecific antibodies. The term “dual-specific antibody”, as used herein, refers to full-length antibodies that can bind two different antigens (or epitopes) in each of its two binding arms (a pair of HC/LC) (see e.g., PCT publication WO 02/02773). Accordingly a dual-specific binding protein has two identical antigen binding arms, with identical specificity and identical CDR sequences, and is bi-valent for each antigen it binds to. The term “bispecific antibody”, as used herein, refers to full-length antibodies that are generated by quadroma technology (see Milstein, C. and A. C. Cuello (1983)  Nature,  305:537-40), by chemical conjugation of two different mAbs (see Staerz, U. D., et al. (1985)  Nature  314:628-31), or by knob-into-hole or similar approaches which introduces mutations in the Fc region (see Holliger, P., T. Prospero, and G. Winter (1993)  Proc. Natl. Acad. Sci. USA  90:6444-8), resulting in multiple different immunogloblin species of which only one is the functional bispecific antibody. By molecular function, a bispecific antibody binds one antigen (or epitope) on one of its two binding arms (one pair of HC/LC), and binds a different antigen (or epitope) on its second arm (a different pair of HC/LC). By this definition, a bispecific antibody has two distinct antigen binding arms (in both specificity and CDR sequences), and is mono-valent for each antigen it binds to. Thus, when used herein, a “bispecific” antibody of the invention has one binding arm that is specific for an epitope of TNFα and a second binding arm that is specific for a different antigen or epitope. 
     The term “antigen-binding portion” of an antibody (or simply “antibody portion”), as used herein, refers to one or more fragments of an antibody that retain the ability to specifically bind to an antigen. It has been shown that the antigen-binding function of an antibody can be performed by fragments of a full-length antibody. Examples of binding fragments encompassed within the term “antigen-binding portion” of an antibody include (i) a Fab fragment, a monovalent fragment consisting of the V L , V H , C L  and C H1  domains; (ii) a F(ab′) 2  fragment, a bivalent fragment comprising two Fab fragments linked by a disulfide bridge at the hinge region; (iii) a Fd fragment consisting of the V H  and C H1  domains; (iv) a Fv fragment consisting of the V L  and V H  domains of a single arm of an antibody, (v) a dAb fragment (Ward et al., (1989)  Nature  341:544-546), which consists of a V H  domain; and (vi) an isolated complementarity determining region (CDR). Furthermore, although the two domains of the Fv fragment, V L  and V H , are coded for by separate genes, they can be joined, using recombinant methods, by a synthetic linker that enables them to be made as a single protein chain in which the V L  and V H  regions pair to form monovalent molecules (known as single chain Fv (scFv); see e.g., Bird et al. (1988)  Science  242:423-426; and Huston et al. (1988)  Proc. Natl. Acad. Sci. USA  85:5879-5883). Such single chain antibodies are also intended to be encompassed within the term “antigen-binding portion” of an antibody. These antibody fragments are obtained using conventional techniques known to those with skill in the art, and the fragments are screened for utility in the same manner as are intact antibodies. 
     The terms “monoclonal antibody” or “monoclonal antibody composition” as used herein refer to a preparation of antibody molecules of single molecular composition. A monoclonal antibody composition displays a single binding specificity and affinity for a particular epitope. 
     The terms “chimeric antibody” or “chimeric monoclonal antibody” are intended to refer to antibodies in which the variable region sequences are derived from one species and the constant region sequences are derived from another species, such as an antibody in which the variable region sequences are derived from a mouse antibody and the constant region sequences are derived from a human antibody. Such “chimeric antibodies” can be prepared by standard recombinant technology well established in the art. For example, a nucleic acid encoding a V H  region from a mouse antibody can be operatively linked to a nucleic acid encoding the heavy chain constant regions from a human antibody and, likewise, a nucleic acid encoding a V L  region from a mouse antibody can be operatively linked to a nucleic acid encoding the light chain constant region from a human antibody. 
     The terms “humanized antibody” or “humanized monoclonal antibody” are intended to refer to antibodies in which CDR sequences derived from the germline of a non-human mammalian species, such as a mouse, have been grafted onto human framework sequences. Additional framework region modifications may be made within the human framework sequences. Such “humanized antibodies” can be prepared by standard recombinant technology well established in the art. For example, nucleic acids encoding the CDR1, CD2 and CDR3 regions from a V H  region of a mouse antibody can be operatively linked to nucleic acids encoding the FR1, FR2, FR3 and FR4 regions of a human V H  region, and the entire “CDR-grafted” V H  region can be operatively linked to nucleic acid encoding the heavy chain constant regions from a human antibody. Likewise, nucleic acids encoding the CDR1, CD2 and CDR3 regions from a V L  region of a mouse antibody can be operatively linked to nucleic acids encoding the FR1, FR2, FR3 and FR4 regions of a human V L  region, and the entire “CDR-grafted” V L  region can be operatively linked to nucleic acid encoding the light chain constant region from a human antibody. 
     The term “human antibody”, as used herein, is intended to refer to antibodies having variable regions in which both the framework and CDR regions are derived from human germline immunoglobulin sequences. Furthermore, if the antibody contains a constant region, the constant region also is derived from human germline immunoglobulin sequences. Human antibodies may include amino acid residues not encoded by human germline immunoglobulin sequences (e.g., mutations introduced by random or site-specific mutagenesis in vitro or by somatic mutation in vivo). 
     The term “human monoclonal antibody” refers to antibodies displaying a single binding specificity which have variable regions in which both the framework and CDR regions are derived from human germline immunoglobulin sequences. Human monoclonal antibodies can be produced by a hybridoma which includes a B cell obtained from a transgenic nonhuman animal, e.g., a transgenic mouse, having a genome comprising a human heavy chain transgene and a light chain transgene fused to an immortalized cell. The term “human monoclonal antibody”, as used herein, also includes all human antibodies that are prepared, expressed, created or isolated by recombinant means, such as (a) antibodies isolated from an animal (e.g., a mouse) that is transgenic or transchromosomal for human immunoglobulin genes or a hybridoma prepared therefrom, (b) antibodies isolated from a host cell transformed to express the human antibody, e.g., from a transfectoma, (c) antibodies isolated from a recombinant, combinatorial human antibody library, and (d) antibodies prepared, expressed, created or isolated by any other means that involve splicing of human immunoglobulin gene sequences to other DNA sequences. Such recombinant human antibodies have variable regions in which the framework and CDR regions are derived from human germline immunoglobulin sequences. Such recombinant human antibodies, however, can be subjected to in vitro mutagenesis (or, when an animal transgenic for human Ig sequences is used, in vivo somatic mutagenesis) and thus the amino acid sequences of the V H  and V L  regions of the recombinant antibodies are sequences that, while derived from and related to human germline V H  and V L  sequences, may not naturally exist within the human antibody germline repertoire in vivo. 
     The terms “Ig fusion protein” and “Fc fusion protein” are intended to refer to a recombinant, composite protein comprising a polypeptide of interest operatively linked to a constant region portion of immunoglobulin, typically the hinge, CH 2  and CH 3  domains of heavy chain constant region, more typically the human IgG1 hinge, CH 2  and CH 3  domains. The polypeptide of interest operatively linked to the Fc portion can be, for example, a full-length protein or only a portion of a full-length protein, such as one or more extracellular domains of a protein, e.g., one or more extracellular domains of a cell-surface protein. Such “Ig fusion proteins” can be prepared by standard recombinant technology well established in the art. For example, a nucleic acid encoding the polypeptide of interest can be operatively linked to a nucleic acid encoding the hinge, CH 2  and CH 3  domains of a heavy chain constant region. 
     The term “multivalent binding protein”, as a form of TNFα inhibitor, is used in this specification to denote a binding protein comprising two or more antigen binding sites. Examples of multivalent binding proteins include dual variable domain (DVD) binding proteins. The multivalent binding protein is preferably engineered to have three or more antigen binding sites, and is generally not a naturally occurring antibody. A multivalent binding protein also can be a “multispecific binding protein.” The term “multispecific binding protein” refers to a binding protein capable of binding two or more related or unrelated targets (wherein, with respect to this specification at least one of the targets is TNFα). Dual variable domain (DVD) binding proteins, as used herein, are binding proteins that comprise two or more antigen binding sites and are tetravalent or multivalent binding proteins. Such DVDs may be monospecific, i.e., capable of binding one antigen (e.g., TNFα) or multispecific, i.e., capable of binding two or more antigens (e.g., TNFα and one or more other antigens). DVD binding proteins comprising two heavy chain DVD polypeptides and two light chain DVD polypeptides are referred to as “DVD Ig.” Each half of a DVD Ig comprises a heavy chain DVD polypeptide, and a light chain DVD polypeptide, and two antigen binding sites. Each binding site comprises a heavy chain variable domain and a light chain variable domain with a total of 6 CDRs involved in antigen binding per antigen binding site. DVD binding proteins and methods of making DVD binding proteins are disclosed in US. Publication No. 20070071675, the entire contents of which are specifically incorporated herein by reference. 
     As used herein, the term “biomarker” is intended to encompass a substance that is used as an indicator of a biologic state and includes genes (and nucleotide sequences of such genes), mRNAs (and nucleotide sequences of such mRNAs) and proteins (and amino acid sequences of such proteins). A “biomarker expression pattern” is intended to refer to a quantitative or qualitative summary of the expression of one or more biomarkers in a subject, such as in comparison to a standard or a control. 
     The terms “increased” or “increased expression” and “decreased” or “decreased expression”, with respect to the expression pattern of a biomarker(s), are used herein as meaning that the level of expression is increased or decreased relative to a constant basal level of expression of a household, or housekeeping, gene, whose expression level does not significantly vary under different conditions. A nonlimiting example of such a household, or housekeeping, gene is GAPDH. Other suitable household, or housekeeping, gene are well-established in the art. 
     As used herein, the term “CD11c” refers to a protein having a full-length amino acid sequence as set forth at Genbank Accession No. NP — 000878 (also shown as SEQ ID NO: 302) and encoded by a full-length nucleotide sequence as set forth at Genbank Accession No. NM — 000887 (also shown as SEQ ID NO: 301). CD11c is also known in the art as CD11C, CD11c antigen, Integrin alpha X, complement component 3 receptor 4 subunit, ITGAX, LeuM5, Integrin alpha X precursor, Leukocyte adhesion glycoprotein p150,p95 alpha chain, and Leukocyte adhesion receptor p150 subunit, which terms may be used interchangeably herein to refer to CD11c. 
     As used herein, the term “Affymetrix ID” refers to a numerical identifier that corresponds to a sequence entry in an Affymetrix database, which entry includes the sequence as well as additional information relating to the sequence and corresponding protein. The sequence entries, and additional information in the entries, for each Affymetrix ID are publicly available (e.g., by entering the Affymetrix ID number into the Affymetrix database search engine, e.g., at https://www.affymetrix.com/analysis/netaffx/index.affx). All sequence entries (such as Genbank Accession numbers), and additional information provided for each entry, corresponding to each of the Affymetrix ID numbers disclosed herein are hereby specifically incorporated by reference in their entirety. 
     As used herein, the term “subject” includes humans, and non-human animals amenable to TNFα inhibitor therapy, e.g., preferably mammals, such as non-human primates, sheep, dogs, cats, horses and cows. 
     As used herein, the term “autoimmune disorder subject” or “AD subject” is intended to refer to a subject (e.g., human patient) suffering from an autoimmune disorder. 
     As used herein, the term “rheumatoid arthritis subject” or “RA subject” is intended to refer to a subject (e.g., human patient) suffering from rheumatoid arthritis. 
     As used herein, the term “treatment regimen” is intended to refer to one or more parameters selected for the treatment of a subject, e.g., with a TNFα inhibitor, which parameters can include, but are not necessarily limited to, the type of agent chosen for administration, the dosage, the formulation, the route of administration and the frequency of administration. 
     Various aspects of the invention are described in further detail in the following subsections. 
     Prediction of Responsiveness to a TNFα Inhibitor for Autoimmune Disorders 
     In one aspect, the invention pertains to a method for predicting responsiveness to a TNFα inhibitor in a subject having an autoimmune disorder, such as rheumatoid arthritis. Typically, the method comprises (i) assaying the subject for the expression of one or more biomarkers predictive of responsiveness to a TNFα inhibitor in an autoimmune disorder, and (ii) predicting responsiveness of the subject to the TNFα inhibitor based on expression of the one or more biomarkers in the subject. As used herein, the term “one or more biomarkers” is intended to mean that at least one biomarker in a disclosed list of biomarkers is assayed and, in various embodiments, more than one biomarker set forth in the list may be assayed, such as two, three, four, five, ten, twenty, thirty, forty, fifty, more than fifty, or all the biomarkers in the list may be assayed. 
     Predicting responsiveness of the subject to the TNFα inhibitor “based on expression of the one or more biomarkers in the subject” typically involves comparing the level, or pattern, of expression of the one or more biomarkers in the subject to a known standard or control (which known standard or control may be derived from, for example, a normal subject, a pre-established TNFα inhibitor responder or a pre-established TNFα inhibitor non-responder). In a preferred embodiment, the level of expression of the biomarker(s) is measured in parallel with measurement of the level of expression of one or more “housekeeping” genes, such as GAPDH, whose expression level is not altered by the autoimmune disorder. The level of expression of the biomarker(s) is determined to be “increased” or “decreased” relative to a constant basal level of expression of the housekeeping gene. Examples of suitable housekeeping genes, such as GAPDH, that can be used for comparison purposes are well known in the art. 
     Preferably, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-82 (corresponding to sequences of the biomarkers set forth in Table 9). Thus, at least one of the biomarkers encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-82 is assayed and, in various embodiments, for example, two, three, four, five, ten, twenty, thirty, forty, fifty, more than fifty, or all the biomarkers in the list may be assayed. 
     In a preferred embodiment, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 6, 7, 10, 15-17, 19, 22, 24, 27, 31, 34-39, 43-47, 49, 51, 54, 55, 57, 59, 61, 62, 64, 70, 75, 79 and 82 (corresponding to sequences from Table 9 that are increased in ≧80% of responders vs. non-responders). More preferably, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 31, 37, 44, 47, 62 and 70 (corresponding to sequences from Table 9 that are increased in ≧90% of responders vs. non-responders). Even more preferably, at least one of the biomarkers to be assayed is encoded by a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO: 44 (corresponding to the biomarker CD11c, which, as set forth in Table 9, is increased in 100% of responders vs. non-responders). In each of these embodiments, increased expression of the one or more biomarkers is predictive of responsiveness of the subject to a TNFα inhibitor (e.g., increased expression relative to a standard or control level of expression, which standard or control level of expression can be based, for example, on the level of expression in previously established TNFα inhibitor non-responder RA subjects). 
     In another preferred embodiment, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 1-5, 8, 9, 11-14, 18, 20, 21, 23, 25, 26, 28-30, 32, 33, 40-42, 48, 50, 52, 53, 56, 58, 60, 63, 65-69, 71-74, 76-78, 80 and 81 (corresponding to sequences from Table 9 that are decreased in ≧80% of responders vs. non-responders). More preferably, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 11, 29, 65, 73 and 74 (corresponding to sequences from Table 9 that are decreased in ≧90% of responders vs. non-responders). Even more preferably, the one or more biomarkers is encoded by a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO: 11 or SEQ ID NO: 74 (corresponding to sequences from Table 9 that are decreased in 100% of responders vs. non-responders). In each of these embodiments, decreased expression of the one or more biomarkers is predictive of responsiveness of the subject to a TNFα inhibitor (e.g., decreased expression relative to a standard or control level of expression, which standard or control level of expression can be based, for example, on the level of expression in previously established TNFα inhibitor non-responder RA subjects). 
     In another aspect, the invention provides a method for predicting responsiveness to a TNFα inhibitor in a subject having an autoimmune disorder, the method comprising: (i) assaying the subject for expression of one or more biomarkers predictive of responsiveness to a TNFα inhibitor in the autoimmune disorder, and (ii) predicting responsiveness of the subject to the TNFα inhibitor based on expression of the one or more biomarkers in the subject, wherein the one or more biomarkers is selected from the group consisting of Aquaporin 3 (Genbank Accession No. NM — 004925); Similar to ribosomal protein S24, clone MGC:8595 (Genbank Accession No. NM — 033022); Transmembrane emp24 domain trafficking protein 2 (Genbank Accession No. NM — 006815; Superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 (Genbank Accession No. NM — 000454); Calmodulin 1 (phosphorylase kinase, delta) (Genbank Accession No. NM — 006888); Guanine nucleotide binding protein (G protein), beta polypeptide 1 (Genbank Accession No. NM — 002074); Prothymosin, alpha (gene sequence 28) (Genbank Accession No. NM — 002823);  Homo sapiens  isocitrate dehydrogenase 1 (NADP + ) soluble (IDH1) (Genbank Accession No. NM — 005896); Tumor protein D52 (Genbank Accession Nos. NM — 001025252, NM — 001025253, NM — 005079); Early growth response 1 (Genbank Accession No. NM — 001964);  Homo sapiens  predicted osteoblast protein (GS3786) (Genbank Accession Nos. NM — 014888, NM — 001040020); Cytochrome c oxidase subunit VIIb (Genbank Accession No. NM — 001866); CUG triplet repeat, RNA binding protein 2 (Genbank Accession No. NM — 001025077, NM — 001025076, NM — 006561); Ubiquinol-cytochrome c reductase hinge protein (Genbank Accession No. NM — 006004);  Homo sapiens  leptin receptor gene-related protein (HS0BRGRP) (Genbank Accession No. NM — 017526); Wiskott-Aldrich syndrome protein interacting protein (Genbank Accession Nos. NM — 001077269, NM — 003387); CD97 antigen (Genbank Accession Nos. NM — 001025160, NM — 001784, NM — 078481); Glutamate-cysteine ligase, catalytic subunit (Genbank Accession No. NM — 001498); Crystallin, zeta (quinone reductase) (Genbank Accession No. NM — 001889); Rap guanine nucleotide exchange factor (GEF) 2 (Genbank Accession No. NM — 014247); Ataxin 1 (Genbank Accession No. NM — 000332); Adaptor-related protein complex 1, sigma 2 subunit (Genbank Accession No. NM — 003916); Ectonucleotide pyrophosphatase/phosphodiesterase 4 (Genbank Accession No. NM — 014936); Desmocollin 2 (Genbank Accession Nos. NM — 024422, NM — 004949); MAL, T-cell differentiation protein (Genbank Accession Nos. NM — 002371, NM — 022438, NM — 022439, NM — 022440); Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (Genbank Accession No. NM — 005476); Chemokine (C—C motif) ligand 3 (Genbank Accession Nos. NM — 001001437, NM — 021006); Carboxypeptidase A3 (Genbank Accession No. NM — 001870); Charcot-Leyden crystal protein (Genbank Accession No. NM — 001828); NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7 kDa (Genbank Accession No. NM — 004545); Interleukin 8 receptor, beta (Genbank Accession No. NM — 001557); Platelet factor 4 variant 1 (Genbank Accession No. NM — 002620); Poly(A) binding protein interacting protein 1 (Genbank Accession No. NM — 006451); ATP-binding cassette, sub-family C (CFTR/MRP), member 3 (Genbank Accession No. NM — 003786); Actinin, alpha 1 (Genbank Accession No. NM — 001102); NAD kinase (Genbank Accession No. NM — 023018); Platelet/endothelial cell adhesion molecule (CD31 antigen) (Genbank Accession No. NM — 000442); Esterase D/formylglutathione hydrolase (Genbank Accession No. NM — 001984); Chromosome 20 open reading frame 111 (Genbank Accession No. NM — 016470); Sterol-C4-methyl oxidase-like (Genbank Accession Nos. NM — 001017369, NM — 006745); PIM-1 oncogene (Genbank Accession No. NM — 002648); GATA binding protein 2 (Genbank Accession No. NM — 032638); Cathepsin Z (Genbank Accession No. NM — 001336); Integrin alpha-X (antigen CD11c) (Genbank Accession No. NM — 000887); Lectin, galactoside-binding, soluble, 8 (galectin 8) (Genbank Accession Nos. NM — 006499, NM — 201545); CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) (Genbank Accession Nos. NM — 006889, NM — 175862); Interleukin 8 (Genbank Accession No. NM — 000584); Fc fragment of IgE, high affinity I, receptor for alpha polypeptide (Genbank Accession No. NM — 002001); Actin, gamma 1 (Genbank Accession No. NM — 001614); KIAA0746 protein (Genbank Accession No. NM — 015187); Glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) (Genbank Accession No. NM — 002076); Transcription factor 4 (Genbank Accession Nos. BF592782, CR612521); Major histocompatibility complex, class II, DQ alpha 1 (Genbank Accession Nos. NM — 002122, NM — 020056); Cell division cycle 2-like 6 (CDK8-like) (Genbank Accession No. NM — 015076); Major histocompatibility complex, class II, DQ beta 1 (Genbank Accession No. XM — 942240); Phospholipase C-like 2 (Genbank Accession No. NM — 015184); Coagulation factor II (thrombin) receptor-like 1 (Genbank Accession No. NM — 005242); TM2 domain containing 1 (Genbank Accession No. NM — 032027); Splicing factor 3b, subunit 1, 155 kDa (Genbank Accession No. NM — 012433); SUB1 homolog ( S. cerevisiae ) (Genbank Accession No. NM — 006713); mRNA; cDNA DKFZp564O0862 (Genbank Accession No. AI278204); Amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease) (Genbank Accession Nos. NM — 201413, NM — 000484, NM — 201414); Cytochrome b-5 (Genbank Accession Nos. NM — 001914, NM — 148923); Cold autoinflammatory syndrome 1 (Genbank Accession No. NM — 183395); Neugrin, neurite outgrowth associated (Genbank Accession Nos. NM — 016645, NM — 001033088); Ribosomal protein S26, 40S ribosomal protein (Genbank Accession No. XM — 941927); CCR4-NOT transcription complex, subunit 6 (Genbank Accession No. NM — 015455); Ubiquinol-cytochrome c reductase complex (7.2 kD) (Genbank Accession Nos. NM — 013387, NM — 001003684); Hepatocellular carcinoma-associated antigen 112 (Genbank Accession No. NM — 018487); Kruppel-like factor 11 (Genbank Accession No. XM — 001129527); GGA binding partner (Genbank Accession No. NM — 018318); Cornichon homolog 4 (Drosophila) (Genbank Accession No. NM — 014184); Hypothetical protein FLJ21616 (Genbank Accession No. NM — 024567);  Homo sapiens  hypothetical protein FLJ10134 (Genbank Accession No. NM — 018004); Nuclear prelamin A recognition factor (Genbank Accession Nos. NM — 012336, NM — 001038618); Erythroblast membrane-associated protein (Genbank Accession Nos. NM — 018538, NM — 001017922); LR8 protein (Genbank Accession No. NM — 014020); Likely ortholog of mouse limb-bud and heart gene (LBH) (Genbank Accession No. NM — 030915); Calmin (calponin-like, transmembrane) (Genbank Accession No. NM — 024734); Chromosome 14 open reading frame 156 (Genbank Accession No. NM — 031210); Guanine nucleotide binding protein (G protein) alpha 12 (Genbank Accession No. NM — 007353); and SRY (sex determining region Y)-box 18 (Genbank Accession No. NR — 003287) (corresponding to biomarkers listed in Table 9). 
     In a preferred embodiment, the one or more biomarkers is selected from the group consisting of Guanine nucleotide binding protein (G protein), beta polypeptide 1; Prothymosin, alpha (gene sequence 28); Early growth response 1;  Homo spaiens  leptin receptor gene-related protein (HS0BRGRP); Wiskott-Aldrich syndrome protein interacting protein; CD97 antigen; Crystallin, zeta (quinone reductase); Adaptor-related protein complex 1, sigma 2 subunit; Desmocollin 2; Chemokine (C—C motif) ligand 3; Interleukin 8 receptor, beta; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; Actinin, alpha 1; NAD kinase; Platelet/endothelial cell adhesion molecule (CD31 antigen); Esterase D/formylglutathione hydrolase; Chromosome 20 open reading frame 111; Cathepsin Z; Integrin alpha-X (antigen CD11c); Lectin, galactoside-binding, soluble, 8 (galectin 8); CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); Interleukin 8; Actin, gamma 1; Glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID); Cell division cycle 2-like 6 (CDK8-like); Major histocompatibility complex, class II, DQ beta 1; Coagulation factor II (thrombin) receptor-like 1; Splicing factor 3b, subunit 1, 155 kDa; mRNA; cDNA DKEZp564O0862; Amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); Cold autoinflammatory syndrome 1; Kruppel-like factor 11; Nuclear prelamin A recognition factor; Calmin (calponin-like, transmembrane); and SRY (sex determining region Y)-box 18 (corresponding to biomarkers listed in Table 9 that are increased in ≧80% of responders vs. non-responders). More preferably, the one or more biomarkers is selected from the group consisting of Interleukin 8 receptor, beta; Platelet/endothelial cell adhesion molecule (CD31 antigen); Integrin alpha-X (antigen CD11c); Interleukin 8; Amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease); and Kruppel-like factor 11 (corresponding to biomarkers listed in Table 9 that are increased in ≧90% of responders vs. non-responders). Even more preferably, at least one of the biomarkers is Integrin alpha-X (antigen CD11c) (corresponding to a biomarker listed in Table 9 that is increased in 100% of responders vs. non-responders). In each of the embodiments, increased expression of the one or more biomarkers is predictive of responsiveness of the subject to a TNFα inhibitor. 
     In another preferred embodiment, the one or more biomarkers is selected from the group consisting of Aquaporin 3; Similar to ribosomal protein S24, clone MGC:8595; Transmembrane emp24 domain trafficking protein 2; Superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1; Calmodulin 1 (phosphorylase kinase, delta);  Homo sapiens  isocitrate dehydrogenase 1 (NADP+) soluble (IDH1); Tumor protein D52;  Homo sapiens  predicted osteoblast protein (GS3786); Cytochrome c oxidase subunit VIIb; CUG triplet repeat, RNA binding protein 2; Ubiquinol-cytochrome c reductase hinge protein; Glutamate-cysteine ligase, catalytic subunit; Rap guanine nucleotide exchange factor (GEF) 2; Ataxin 1; Ectonucleotide pyrophosphatase/phosphodiesterase 4; MAL, T-cell differentiation protein; Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase; Carboxypeptidase A3; Charcot-Leyden crystal protein; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7 kDa; Platelet factor 4 variant 1; Poly(A) binding protein interacting protein 1; Sterol-C4-methyl oxidase-like; PIM-1 oncogene; GATA binding protein 2; Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide; KIAA0746 protein; Transcription factor 4; Major histocompatibility complex, class II, DQ alpha 1; Phospholipase C-like 2; TM2 domain containing 1; SUB1 homolog ( S. cerevisiae ); Cytochrome b-5; Neugrin, neurite outgrowth associated; Ribosomal protein S26, 40S ribosomal protein; CCR4-NOT transcription complex, subunit 6; Ubiquinol-cytochrome c reductase complex (7.2 kD); Hepatocellular carcinoma-associated antigen 112; GGA binding partner; Cornichon homolog 4 (Drosophila); Hypothetical protein FLJ21616;  Homo sapiens  hypothetical protein FLJ10134; Erythroblast membrane-associated protein; LR8 protein; Likely ortholog of mouse limb-bud and heart gene (LBH); Chromosome 14 open reading frame 156; and Guanine nucleotide binding protein (G protein) alpha 12 (corresponding to biomarkers listed in Table 9 that are decreased in ≧80% of responders vs. non-responders). More preferably, the one or more biomarkers is selected from the group consisting of  Homo sapiens  predicted osteoblast protein (GS3786); Charcot-Leyden crystal protein; Neugrin, neurite outgrowth associated; Hypothetical protein FLJ21616; and  Homo sapiens  hypothetical protein FLJ10134 (corresponding to biomarkers listed in Table 9 that are decreased in ≧90% of responders vs. non-responders). Even more preferably, the one or more biomarkers is  Homo sapiens  predicted osteoblast protein (GS3786) or  Homo sapiens  hypothetical protein FLJ10134 (corresponding to biomarkers listed in Table 9 that are decreased in 100% of responders vs. non-responders). In each of these embodiments, decreased expression of the one or more biomarkers is predictive of responsiveness of the subject to a TNFα inhibitor. 
     In a particularly preferred aspect, the invention provides a method for predicting responsiveness to a TNFα inhibitor in a subject having an autoimmune disorder the method comprising: (i) assaying the subject for increased expression of a biomarker, which biomarker is CD11c, and (ii) predicting responsiveness of the subject to the TNFα inhibitor based on increased expression of CD11c in the subject. 
     In yet another particularly preferred embodiment, the invention provides a method for predicting responsiveness to a TNFα inhibitor, which TNFα inhibitor is adalimumab, in a subject having an autoimmune disorder the method comprising: (i) assaying the subject for expression of one or more biomarkers predictive of responsiveness to adalimumab in the autoimmune disorder, and (ii) predicting responsiveness of the subject to adalimumab based on expression of the one or more biomarkers in the subject. Preferably, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-82 (or selected from the group consisting of the biomarkers set forth in Table 9). In more preferred embodiments, the subsets of sequences within SEQ ID NO: 1-82 that are either increased or decreased, as set forth in detail above, can be assayed. 
     In the methods of the invention for predicting responsiveness to a TNFα inhibitor in a subject having an autoimmune disorder, the expression of one or more biomarkers predictive of responsiveness to a TNFα inhibitor in the autoimmune disorder can be assayed in the subject using techniques well-established in the art. In a preferred embodiment, the expression of the one or more biomarkers in the subject is assayed by obtaining an mRNA sample from the subject (e.g., isolated from peripheral blood mononuclear cells, by standard methods) and detecting the expression of mRNA(s) encoding the one or more biomarkers in the mRNA sample using standard molecular biology techniques, such as PCR analysis. A preferred method of PCR analysis is revers transcriptase-polymerase chain reaction (RT-PCR). Other suitable systems for mRNA sample analysis include microarray analysis (e.g., using Affymetrix&#39;s microarray system or Illumina&#39;s BeadArray Technology). 
     Additionally or alternatively, in certain situations it may be possible to assay for the expression of one or more biomarkers at the protein level, using a detection reagent that detects the protein product encoded by the mRNA of the biomarker(s). For example, if an antibody reagent is available that binds specifically to the biomarker protein product to be detected, and not to other proteins, then such an antibody reagent can be used to detect the expression of the biomarker of interest in a cellular sample from the subject, or a preparation derived from the cellular sample, using standard antibody-based techniques known in the art, such as FACS analysis, ELISA and the like. 
     It will be readily understood by the ordinarily skilled artisan that essentially any technical means established in the art for detecting biomarkers, at either the nucleic acid or protein level, can be adapted to detection of the biomarkers discussed herein and applied in the methods of the current invention for predicting responsiveness to a TNFα inhibitor in a subject having an autoimmune disorder. 
     The biomarkers described herein were originally identified in patients having rheumatoid arthritis (see the Examples) and thus a particularly preferred autoimmune disorder in which to apply the methods of the invention is rheumatoid arthritis. The mechanism of action of the TNFα pathway, however, is thought to be common to a large number of autoimmune disorders and TNFα inhibitors have been shown to be effective therapy in a variety of different autoimmune disorders. Accordingly, the method of the invention for predicting responsiveness to a TNFα inhibitor can be applied to essentially any autoimmune disorder in which TNFα inhibitor therapy is applied. Other preferred autoimmune disorders include Crohn&#39;s disease, ulcerative colitis, psoriasis, psoriatic arthritis, juvenile arthritis and ankylosing spondilitis, Other non-limiting examples of autoimmune disorders include autoimmune diabetes, multiple sclerosis, systemic lupus erythematosus, rheumatoid spondylitis, gouty arthritis, allergy, autoimmune uveitis, nephrotic syndrome, multisystem autoimmune diseases, autoimmune hearing loss, adult respiratory distress syndrome, shock lung, chronic pulmonary inflammatory disease, pulmonary sarcoidosis, pulmonary fibrosis, silicosis, idiopathic interstitial lung disease, chronic obstructive pulmonary disease, asthma, restenosis, spondyloarthropathies, Reiter&#39;s syndrome, autoimmune hepatitis, inflammatory skin disorders, vasculitis of large vessels, medium vessels or small vessels, endometriosis, prostatitis and Sjogren&#39;s syndrome. 
     Biomarkers for Monitoring an Autoimmune Disorder in a Subject 
     In another aspect, the invention provides methods of monitoring an autoimmune disorder in a subject having the autoimmune disorder based on biomarker expression patterns established using microarray analysis of, for example, RA subjects vs. normal donors, RA subjects vs. RA subjects treated with a TNFα inhibitor and/or RA subjects treated with a TNFα inhibitor vs. RA responders to TNFα inhibitors. In these monitoring methods, the subject is assayed for expression of one or more biomarkers (using techniques, for example, as described in the previous section), thereby monitoring the autoimmune disorder in the subject. 
     In one embodiment of the monitoring method, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 83-133 (or the biomarkers set forth by name in Table 3, namely v-maf musculoaponeurotic fibrosarcoma oncogene homolog F; Diphtheria toxin receptor (DTR); DEAH (Asp-Glu-Ala-His) box polypeptide 15; Ribonucleotide reductase M2 polypeptide; Solute carrier family 6, member 8; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; Ferrochelatase (protoporphyria); Nuclear factor, interleukin 3 regulated; Thrombomodulin; Major histocompatibility complex, class II, DM beta; Forkhead box O3A; Hemoglobin, gamma A, gamma G; Synuclein, alpha (non A4 component of amyloid precursor); Hemoglobin, gamma A; Amphiregulin (schwannoma-derived growth factor); Lipoyltransferase 1; Solute carrier family 4, anion exchanger, member 1; S100 calcium binding protein A12 (calgranulin C); Keratin 1 (epidermolytic hyperkeratosis); Carbonic anhydrase I; CD1C antigen, c polypeptide; Tumor necrosis factor, alpha-induced protein 6; Ribonuclease, RNase A family, 2; Hemoglobin, delta; Transferrin receptor (p90, CD71); Ring finger protein 10; Chromosome 1 open reading frame 63; Hemoglobin, alpha 1, alpha 2; CD69 antigen (p60, early T-cell activation antigen; APEX nuclease (multifunctional DNA repair enzyme) 1; Membrane-spanning 4-domains, subfamily A, member 3; Heat shock 70 kDa protein 8; Hypothetical protein MGC12760; GABA(A) receptor-associated protein like 1, like 3; Aminolevulinate, delta-, synthase 2; Major histocompatibility complex, class II, DP alpha 1; Morf4 family associated protein 1-like 1; Aldehyde dehydrogenase 1 family, member A1; Formin binding protein 4; Zinc finger protein 24 (KOX 17); Hypothetical protein L0054103; Selenium binding protein 1; Hematopoietically expressed homeobox; Major histocompatibility complex, class II, DM alpha; Eukaryotic translation initiation factor 2-alpha kinase 1; Ankyrin repeat domain 49; Hypothetical protein FLJ20701; Zinc finger protein 331; Membrane-spanning 4-domains, subfamily A, member 4; Tensin 1; and Family with sequence similarity 46, member A, respectively). 
     In another embodiment of the monitoring method, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 134-177, 110, 112, 118, 123 and 131 (or the biomarkers set forth by name in Table 4, namely Uncharacterized hypothalamus protein HT007; Dual specificity phosphatase 22; Proteasome (prosome, macropain) subunit, beta type, 7; Membrane-spanning 4-domains, subfamily A, member 4; DKFZP434C171 protein; Protein phosphatase 1, catalytic subunit, beta isoform; Splicing factor, arginine/serine-rich 5; Sorting nexin 11; Farnesyltransferase, CAAX box, alpha; Peroxisomal D3,D2-enoyl-CoA isomerise; Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1; Hypothetical protein FLJ11259; APEX nuclease (multifunctional DNA repair enzyme) 1; Geranylgeranyl diphosphate synthase 1; Down syndrome critical region gene 5; Calpain 7; Major histocompatibility complex, class II, DP alpha 1; Brix domain containing 5; Chromosome 21 open reading frame 59; Tumor necrosis factor (ligand) superfamily, member 10; Chromosome 10 open reading frame 86; CD1D antigen, d polypeptide; Ewing sarcoma breakpoint region 1; Ribonuclease P 40 kDa subunit; PHD finger protein 20; Thioredoxin interacting protein; Ubiquinol-cytochrome c reductase core protein II; Hypothetical protein FLJ22662; Preimplantation protein 3; DKFZP564G2022 protein; Dipeptidase 2; Hemoglobin, alpha 1, alpha 2; Frequently rearranged in advanced T-cell lymphomas; DEAD (Asp-Glu-Ala-Asp) box polypeptide 48; Tumor necrosis factor, alpha-induced protein 2; Nucleophosmin (nucleolar phosphoprotein B23, numatrin); Interleukin 13 receptor, alpha 1; Leukocyte specific transcript 1, LST1; CGI-121 protein; RAS p21 protein activator 4/hypothetical protein FLJ21767; Cathepsin S; CD63 antigen (melanoma 1 antigen); JTV1 gene; KIAA0174; Thrombospondin 1; Hypothetical protein L0054103; Interferon regulatory factor 1; and SEC11-like 1 ( S. cerevisiae )). 
     More preferably, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 134-150, 112, 118 (or the biomarkers set forth by name in Table 4 as being upregulated, namely Uncharacterized hypothalamus protein HT007; Dual specificity phosphatase 22; Proteasome (prosome, macropain) subunit, beta type, 7; Membrane-spanning 4-domains, subfamily A, member 4; DKEZP434C171 protein; Protein phosphatase 1, catalytic subunit, beta isoform; Splicing factor, arginine/serine-rich 5; Sorting nexin 11; Farnesyltransferase, CAAX box, alpha; Peroxisomal D3,D2-enoyl-CoA isomerise; Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1; Hypothetical protein FLJ11259; APEX nuclease (multifunctional DNA repair enzyme) 1; Geranylgeranyl diphosphate synthase 1; Down syndrome critical region gene 5; Calpain 7; Major histocompatibility complex, class II, DP alpha 1; Brix domain containing 5; and Chromosome 21 open reading frame 59), wherein expression of the one or more biomarkers is increased in the subject. 
     Additionally or alternatively, more preferably the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 151-177, 110 and 123 (or the biomarkers set forth by name in Table 4 as being downregulated, namely Tumor necrosis factor (ligand) superfamily, member 10; Chromosome 10 open reading frame 86; CD1D antigen, d polypeptide; Ewing sarcoma breakpoint region 1; Ribonuclease P 40 kDa subunit; PHD finger protein 20; Thioredoxin interacting protein; Ubiquinol-cytochrome c reductase core protein II; Hypothetical protein FLJ22662; Preimplantation protein 3; DKFZP564G2022 protein; Dipeptidase 2; Hemoglobin, alpha 1, alpha 2; Frequently rearranged in advanced T-cell lymphomas; DEAD (Asp-Glu-Ala-Asp) box polypeptide 48; Tumor necrosis factor, alpha-induced protein 2; Nucleophosmin (nucleolar phosphoprotein B23, numatrin); Interleukin 13 receptor, alpha 1; Leukocyte specific transcript 1, LST1; CGI-121 protein; RAS p21 protein activator 4/hypothetical protein FLJ21767; Cathepsin S; CD63 antigen (melanoma 1 antigen); JTV1 gene; KIAA0174; Thrombospondin 1; Hypothetical protein L0054103; Interferon regulatory factor 1; and SEC11-like 1 ( S. cerevisiae ), wherein expression of the one or more biomarkers is decreased in the subject. 
     In yet another embodiment of the monitoring method, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 178-292, 91 and 97 (or the biomarkers set forth by name in Table 5, namely HLA-B associated transcript-1 (D6S81E); Interleukin enhancer binding factor 2, 45 kD (ILF2); Isolate Liv chaperone protein HSP90 beta (HSP90BETA) mRNA; Lysyl-tRNA synthetase mRNA, complete cds; nuclear gene for mitochondrial product; alternatively spliced; Tryptophanyl-tRNA synthetase (WARS); Profilin 1 (PFN1), mRNA; Seryl-tRNA synthetase (SARS); Similar to KIAA1007 protein, clone MGC:692, mRNA, complete cds; CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344);  Homo sapiens  KIAA0064 gene product (KIAA0064), mRNA; Chromosome segregation 1 (yeast homolog)-like (CSE1L), mRNA; Protein phosphatase 1, regulatory subunit 7 (PPP1R7), mRNA; DEADH (Asp-Glu-Ala-AspHis) box polypeptide 1 (DDX1), mRNA; Threonyl-tRNA synthetase (TARS), mRNA; Dead box protein 15 mRNA, complete cds; SRY (sex determining region Y)-box 4/DEF=Human DNA sequence from clone RP3-322L4 on chromosome 6; Galactosidase, beta 1 (GLB1), mRNA; ATP-binding cassette, sub-family E (OABP), member 1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6 (14 kD, B14) (NDUFA6), mRNA; Pericentriolar material 1 (PCM1), mRNA; Excision repair cross-complementing rodent repair deficiency, complementation group 3 (ERCC3), mRNA; KIAA0907 protein (KIAA0907), mRNA; v-crk avian sarcoma virus CT10 oncogene homolog; 6-phosphofructo-2-kinasefructose-2,6-biphosphatase 3 (PFKFB3), mRNA./PROD=6-phosphofructo-2-kinase-fructose-2,6-biphosphatase 3; KIAA0766 gene product (KIAA0766), mRNA; N-acetylgalactosaminidase, alpha- (NAGA), mRNA; Protein tyrosine phosphatase, non-receptor type substrate 1 (PTPNS1), mRNA; Crystallin, zeta (quinone reductase) (CRYZ), mRNA; KIAA0429 gene product (KIAA0429), mRNA; SET domain, bifurcated 1 (SETDB1), mRNA; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3 (12 kD, B12) (NDUFB3), mRNA; Diphtheria toxin receptor (DTR); Thrombomodulin (THBD), mRNA; Protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform (PPM1A), mRNA; CD37 antigen (CD37), mRNA; Hemoglobin, gamma G (HBG2), mRNA; Protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D), mRNA; Hematopoietically expressed homeobox (HHEX), mRNA; Amphiregulin (schwannoma-derived growth factor) (AREG), mRNA; Early growth response 2 (Krox-20 (Drosophila) homolog) (EGR2), mRNA; 2,5-oligoadenylate synthetase 1 (40-46 kD) (OAS1), transcript variant E16, mRNA; Early growth response 3 (EGR3), mRNA./PROD=early growth response 3;  Homo sapiens  MD-2 protein (MD-2), mRNA;  Homo sapiens  MAX dimerization protein (MAD), mRNA; DKEZP586A011 protein (DKEZP586A011), mRNA; 78 kDa gastrin-binding protein mRNA, complete cds; Transferrin receptor (p90, CD71), clone MGC:3151, mRNA, complete cds;  Homo sapiens  mRNA; cDNA DKFZp564N1272 (from clone DKFZp564N1272); complete cds; GABA-A receptor-associated protein like 1 (GABARAPL1) mRNA, complete cds; Translocation protein 1;  Homo sapiens  clone 016b03 My027 protein mRNA, complete cds; Protein kinase-related oncogene (PIM1) mRNA, complete cds; MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C); eIF-2-associated p67 homolog mRNA, complete cds; Human mRNA for hCREM (cyclic AMP-responsive element modulator) type 2 protein, complete cds; Apurinic endonuclease (APE) mRNA, complete cds./PROD=apurinic endonuclease; TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100 kD; Human mRNA for ZFM1 protein alternatively spliced product, complete cds./PROD=ZFM1 protein, alternatively spliced product; Trachea cellular apoptosis susceptibility protein (CSE1) mRNA, complete cds; Similar to eukaryotic translation initiation factor 3, subunit 8 (110 kD), clone MGC:8693, mRNA, complete cds; GABA-A receptor-associated protein mRNA, complete cds./PROD=GABA-A receptor-associated protein; Human (clone 2-5) synuclein (NACP) mRNA, complete cds; Human putative ribosomal protein 51 mRNA; Aldehyde dehydrogenase 1, soluble (ALDH1), mRNA./PROD=aldehyde dehydrogenase 1, soluble;  Homo sapiens  mRNA for KIAA1057 protein, partial cds; RBP1-like protein; Ring finger protein 4; KIAA0197 protein;  Homo sapiens  mRNA; cDNA DKFZp586F1323 (from clone DKFZp586F1323);  Homo sapiens  mRNA; cDNA DKFZp5641052 (from clone DKFZp5641052);  Homo sapiens  mRNA for Hmob33 protein, 3 untranslated region;  Homo sapiens  mRNA; cDNA DKFZp586F1019 (from clone DKFZp586F1019); partial cds; Myosin, light polypeptide 4, alkali; atrial, embryonic;  H. sapiens  novel gene from PAC 117P20, chromosome 1;  Homo sapiens  clone 24582 mRNA sequence; Heterogeneous nuclear ribonucleoprotein H1 (H); Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; Cyclin T2; cDNA: FLJ23227 fis, clone CAE00645, highly similar to AF052138; Hypothetical protein FLJ12619; C-terminal binding protein 1; SEC22, vesicle trafficking protein ( S. cerevisiae )-like 1; Hemoglobin, alpha 1;  Homo sapiens  clone 24659 mRNA sequence/DEF= Homo sapiens  clone 24659 mRNA sequence; Calcium channel, voltage-dependent, PQ type, alpha 1A subunit;  H. sapiens  SMAS mRNA;  H. sapiens  HEX gene encoding homeobox related protein; Mitogen-activated protein kinase kinase kinase 4; Serine palmitoyltransferase (LCB2) mRNA, partial cds; KIAA0971 protein/DEF= Homo sapiens  cDNA FLJ11495 fis, clone HEMBA1001950, highly similar to  Homo sapiens  mRNA for KIAA0971 protein; ESTs, Hs.97109; ESTs, Weakly similar to ALU7_HUMAN ALU; DEAD-box protein abstrakt (ABS), mRNA; KIAA1513 protein (KIAA1513), mRNA; Cell division protein FtsJ (FJH1), mRNA; F-box only protein 3 (FBXO3), mRNA; Purinergic receptor (family A group 5) (P2Y5), mRNA; Integral inner nuclear membrane protein (MAN1), mRNA; Fanconi anemia, complementation group F (FANCF), mRNA; Hypothetical protein FLJ12820 (FLJ12820), mRNA; Hypothetical protein FLJ13119 (FLJ13119), mRNA; Hypothetical protein FLJ20189 (FLJ20189), mRNA; Hypothetical protein FLJ20701 (FLJ20701), mRNA;  Homo sapiens  chromosome 12 open reading frame 5 (C12ORF5), mRNA; Hypothetical protein FLJ22555 (FLJ22555), mRNA; Hypothetical protein FLJ11110 (FLJ11110), mRNA; CGI-12 protein (LOC51001), mRNA; Triggering receptor expressed on myeloid cells 1 (TREM1), mRNA; betaGlcNAc beta 1,4-galactosyltransferase. polypeptide 5; PNAS-25 mRNA, complete cds.;  Homo sapiens  mRNA for FLJ00043 protein, partial cds;  Homo sapiens  cDNA: FLJ21737 fis, clone COLF3396;  Homo sapiens  cDNA FLJ13399 fis, clone PLACE1001395/DEF=Homo sapiens cDNA FLJ13399 fis, clone PLACE1001395; Novel MAFF (v-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein F) LIKE protein; Heparin-binding EGF-like growth factor mRNA, complete cds;  E. coli  7,8-diamino-pelargonic acid (bioA), biotin synthetase (bioB), 7-keto-8-amino-pelargonic acid synthetase (bioF), bioC protein, and dethiobiotin synthetase (bioD), complete cds;  Escherichia coli /REF=J04423/DEF= E. coli  bioC protein corresponding to nucleotides 4609-4883 of J04423/LEN=777 (−5 and −3 represent transcript regions 5 prime and 3 prime respectively)). 
     More preferably, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 178-185; 187-200, 202, 203, 205-207; 211, 213, 214, 216, 220, 221, 226, 228, 229, 231, 232, 234, 235, 238-247, 249, 250, 253, 262-265, 268-282 and 285-288 (or the biomarkers set forth by name in Table 5 as being upregulated, namely HLA-B associated transcript-1 (D6S81E); Interleukin enhancer binding factor 2, 45 kD (ILF2); Isolate Liv chaperone protein HSP90 beta (HSP90BETA) mRNA; Lysyl-tRNA synthetase mRNA, complete cds; nuclear gene for mitochondrial product; alternatively spliced; Tryptophanyl-tRNA synthetase (WARS); Profilin 1 (PFN1), mRNA; Seryl-tRNA synthetase (SARS); Similar to KIAA1007 protein, clone MGC:692, mRNA, complete cds;  Homo sapiens  KIAA0064 gene product (KIAA0064), mRNA; Chromosome segregation 1 (yeast homolog)-like (CSE1L), mRNA; Protein phosphatase 1, regulatory subunit 7 (PPP1R7), mRNA; DEADH (Asp-Glu-Ala-AspHis) box polypeptide 1 (DDX1), mRNA; Threonyl-tRNA synthetase (TARS), mRNA; Dead box protein 15 mRNA, complete cds; SRY (sex determining region Y)-box 4/DEF=Human DNA sequence from clone RP3-322L4 on chromosome 6; Galactosidase, beta 1 (GLB1), mRNA; ATP-binding cassette, sub-family E (OABP), member 1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6 (14 kD, B14) (NDUFA6), mRNA; Pericentriolar material 1 (PCM1), mRNA; Excision repair cross-complementing rodent repair deficiency, complementation group 3 (ERCC3), mRNA; KIAA0907 protein (KIAA0907), mRNA; v-crk avian sarcoma virus CT10 oncogene homolog; KIAA0766 gene product (KIAA0766), mRNA; N-acetylgalactosaminidase, alpha- (NAGA), mRNA; Crystallin, zeta (quinone reductase) (CRYZ), mRNA; KIAA0429 gene product (KIAA0429), mRNA; SET domain, bifurcated 1 (SETDB1), mRNA; CD37 antigen (CD37), mRNA; Protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D), mRNA; Hematopoietically expressed homeobox (HHEX), mRNA; 2,5-oligoadenylate synthetase 1 (40-46 kD) (OAS1), transcript variant E16, mRNA; DKFZP586A011 protein (DKFZP586A011), mRNA; 78 kDa gastrin-binding protein mRNA, complete cds;  Homo sapiens  clone 016b03 My027 protein mRNA, complete cds; MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C); eIF-2-associated p67 homolog mRNA, complete cds; Apurinic endonuclease (APE) mRNA, complete cds./PROD=apurinic endonuclease; TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100 kD; Trachea cellular apoptosis susceptibility protein (CSE1) mRNA, complete cds; Similar to eukaryotic translation initiation factor 3, subunit 8 (110 kD), clone MGC:8693, mRNA, complete cds; Human putative ribosomal protein 51 mRNA; Aldehyde dehydrogenase 1, soluble (ALDH1), mRNA./PROD=aldehyde dehydrogenase 1, soluble;  Homo sapiens  mRNA for KIAA1057 protein, partial cds; RBP1-like protein; Ring finger protein 4; KIAA0197 protein;  Homo sapiens  mRNA; cDNA DKFZp586F1323 (from clone DKFZp586F1323);  Homo sapiens  mRNA; cDNA DKFZp5641052 (from clone DKFZp5641052);  Homo sapiens  mRNA for Hmob33 protein, 3 untranslated region;  Homo sapiens  mRNA; cDNA DKFZp586F1019 (from clone DKFZp586F1019); partial cds;  H. sapiens  novel gene from PAC 117P20, chromosome 1;  Homo sapiens  clone 24582 mRNA sequence; Cyclin T2;  H. sapiens  HEX gene encoding homeobox related protein; Mitogen-activated protein kinase kinase kinase 4; Serine palmitoyltransferase (LCB2) mRNA, partial cds; KIAA0971 protein/DEF= Homo sapiens  cDNA FLJ11495 fis, clone HEMBA1001950, highly similar to  Homo sapiens  mRNA for KIAA0971 protein; DEAD-box protein abstrakt (ABS), mRNA; KIAA1513 protein (KIAA1513), mRNA; Cell division protein FtsJ (FJH1), mRNA; F-box only protein 3 (FBXO3), mRNA; Purinergic receptor (family A group 5) (P2Y5), mRNA; Integral inner nuclear membrane protein (MAN1), mRNA; Fanconi anemia, complementation group F (FANCF), mRNA; Hypothetical protein FLJ12820 (FLJ12820), mRNA; Hypothetical protein FLJ13119 (FLJ13119), mRNA; Hypothetical protein FLJ20189 (FLJ20189), mRNA; Hypothetical protein FLJ20701 (FLJ20701), mRNA;  Homo sapiens  chromosome 12 open reading frame 5 (C12ORF5), mRNA; Hypothetical protein FLJ22555 (FLJ22555), mRNA; Hypothetical protein FLJ11110 (FLJ11110), mRNA; CGI-12 protein (LOC51001), mRNA; PNAS-25 mRNA, complete cds.;  Homo sapiens  mRNA for FLJ00043 protein, partial cds;  Homo sapiens  cDNA: FLJ21737 fis, clone COLF3396;  Homo sapiens  cDNA FLJ13399 fis, clone PLACE1001395/DEF= Homo sapiens  cDNA FLJ13399 fis, clone PLACE1001395), wherein expression of the one or more biomarkers is increased in the subject. 
     Additionally or alternatively, more preferably the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 186, 201, 204, 208, 209, 91, 210, 212, 97, 215, 217-219, 222-225, 227, 230, 233, 236, 237, 248, 251, 252, 254-261, 266, 267, 283, 284 and 289-292 (or the biomarkers set forth by name in Table 5 as being down-regulated, namely CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344); 6-phosphofructo-2-kinasefructose-2,6-biphosphatase 3 (PFKFB3), mRNA./PROD=6-phosphofructo-2-kinase-fructose-2,6-biphosphatase 3; Protein tyrosine phosphatase, non-receptor type substrate 1 (PTPNS1), mRNA; NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3 (12 kD, B12) (NDUFB3), mRNA; Diphtheria toxin receptor (DTR); Thrombomodulin (THBD), mRNA; Protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform (PPM1A), mRNA; Hemoglobin, gamma G (HBG2), mRNA; Amphiregulin (schwannoma-derived growth factor) (AREG), mRNA; Early growth response 2 (Krox-20 (Drosophila) homolog) (EGR2), mRNA; Early growth response 3 (EGR3), mRNA./PROD=early growth response 3;  Homo sapiens  MD-2 protein (MD-2), mRNA;  Homo sapiens  MAX dimerization protein (MAD), mRNA; Transferrin receptor (p90, CD71), clone MGC:3151, mRNA, complete cds;  Homo sapiens  mRNA; cDNA DKFZp564N1272 (from clone DKFZp564N1272); complete cds; GABA-A receptor-associated protein like 1 (GABARAPL1) mRNA, complete cds; Translocation protein 1; Protein kinase-related oncogene (PIM1) mRNA, complete cds; Human mRNA for hCREM (cyclic AMP-responsive element modulator) type 2 protein, complete cds; Human mRNA for ZFM1 protein alternatively spliced product, complete cds./PROD=ZFM1 protein, alternatively spliced product; GABA-A receptor-associated protein mRNA, complete cds./PROD=GABA-A receptor-associated protein; Human (clone 2-5) synuclein (NACP) mRNA, complete cds; Myosin, light polypeptide 4, alkali; atrial, embryonic; Heterogeneous nuclear ribonucleoprotein H1 (H); Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; cDNA: FLJ23227 fis, clone CAE00645, highly similar to AF052138; Hypothetical protein FLJ12619; C-terminal binding protein 1; SEC22, vesicle trafficking protein ( S. cerevisiae )-like 1; Hemoglobin, alpha 1;  Homo sapiens  clone 24659 mRNA sequence/DEF= Homo sapiens  clone 24659 mRNA sequence; Calcium channel, voltage-dependent, PQ type, alpha 1A subunit;  H. sapiens  SMA5 mRNA; ESTs, Hs.97109; ESTs, Weakly similar to ALU7_HUMAN ALU; Triggering receptor expressed on myeloid cells 1 (TREM1), mRNA; betaGlcNAc beta 1,4-galactosyltransferase. polypeptide 5; Novel MAFF (v-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein F) LIKE protein; Heparin-binding EGF-like growth factor mRNA, complete cds;  E. coli  7,8-diamino-pelargonic acid (bioA), biotin synthetase (bioB), 7-keto-8-amino-pelargonic acid synthetase (bioF), bioC protein, and dethiobiotin synthetase (bioD), complete cds;  Escherichia coli /REF=J04423/DEF= E. coli  bioC protein corresponding to nucleotides 4609-4883 of J04423/LEN=777 (−5 and −3 represent transcript regions 5 prime and 3 prime respectively)), wherein expression of the one or more biomarkers is decreased in the subject. 
     In yet another embodiment of the monitoring method, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 87, 97, 101, 293, 92, 272, 93, 107, 108, 121 and 123 (or the biomarkers set forth by name in Table 6 as pre-treatment biomarkers, namely Solute carrier family 6; Amphiregulin; Keratin 1; Hemoglobin, alpha 1; MHC-II, DM beta; Purinergic receptor P2Y, G-protein coupled 5; Forkhead box O3A; Transferrin receptor (p90, CD71); Ring finger protein 10; Formin binding protein 4; and Hypothetical protein LOC54103), wherein the subject is monitored prior to treatment with a TNFα inhibitor. 
     In yet another embodiment of the monitoring method, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 290, 209, 98, 112, 116, 121, 130, 155, 92, 289, 216 and 131 (or the biomarkers set forth by name in Table 6 as post-treatment biomarkers, namely Diphteria toxin receptor; Heparin-binding EGF-like growth factor; Lipoyltransferase 1; APEX nuclease (multifunct. DNA repair enzyme) 1; GABA(A) receptor-associated protein like 1/3; Formin binding protein 4; Zinc finger protein 331; Ribonuclease P 40 kDa subunit; MHC class II, DM beta; v-maf fibrosarc. oncogene homolog F (avian); 2′,5′-oligoadenylate synthetase 1, 40/46 kDa; and Membrane-spanning 4-domains, subfam. A, memb. 4), wherein the subject is monitored after treatment with a TNFα inhibitor. 
     In yet another embodiment of the monitoring method, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 97, 102, 29, 294, 295, 91, 131, 290, 100, 134, 296, 297, 298, 299, 136, 174 and 300 (or the biomarkers set forth by name in Table 7, namely Amphiregulin; Carbonic anhydrase 1; Charcot-Leyden crystal protein; Clusterin C; Tumor necrosis factor alpha induced protein 6; Thrombomodulin; Membrane-spanning 4-domains, subfamily A, member 4; Diptheria toxin receptor; S100 calcium binding protein A1; Uncharacterized hypothalamus protein HT007; MHC-class-II; HLA-DR alpha; Hypothetical protein L0054103; Tumor necrosis factor alpha; Interleukin 1 beta; Proteasome subunit beta type 7 precursor; and Protein KIAA0174; Microsomal signal peptidase 18 kDa subunit). 
     A preferred autoimmune disorder in which to apply the methods of the invention for monitoring an autoimmune disorder is rheumatoid arthritis. However, the monitoring methods can be applied to essentially any autoimmune disorder in which TNFα inhibitor therapy is applied, including the autoimmune disorders listed in the previous section. 
     Selection and Use of Treatment Regimens with TNFα Inhibitors 
     Given the observation that the expression pattern of particular biomarkers in an autoimmune disorder subject influences the responsiveness of the subject to a TNFα inhibitor, one can select an appropriate treatment regimen for the subject based on the expression of one or more biomarkers in the subject. Accordingly, in one embodiment, the above-described method for predicting the responsiveness to a TNFα inhibitor in a subject having an autoimmune disorder further comprises selecting a treatment regimen with the TNFα inhibitor based upon expression of the one or more biomarkers in the subject. In another aspect, the method still further comprises administering the TNFα inhibitor to the subject according to the treatment regimen such that the autoimmune disorder is inhibited in the subject. 
     In another embodiment, the invention provides a method for selecting a treatment regimen for therapy with a TNFα inhibitor in a subject having an autoimmune disorder, the method comprising: 
     assaying the subject for expression of one or more biomarkers predictive of responsiveness to a TNFα inhibitor for treatment of the autoimmune disorder; and 
     selecting a treatment regimen with a TNFα inhibitor based upon expression of the one or more biomarkers in the subject. 
     In yet another embodiment, the invention provides a method of treating a subject having an autoimmune disorder with a TNFα inhibitor, the method comprising: 
     assaying the subject for expression of one or more biomarkers predictive of responsiveness to a TNFα inhibitor for treatment of the autoimmune disorder; 
     selecting a treatment regimen with a TNFα inhibitor based upon expression of the one or more biomarkers in the subject; and 
     administering the TNFα inhibitor according to the treatment regimen such that the subject is treated for the autoimmune disorder. 
     The treatment regimen that is selected typically includes at least one of the following parameters and more typically includes many or all of the following parameters: the type of agent chosen for administration, the dosage, the formulation, the route of administration and/or the frequency of administration. 
     Particularly preferred TNFα inhibitors are biologic agents that have been approved by the FDA for use in humans in the treatment of rheumatoid arthritis, which agents include adalimumab (HUMIRA™), infliximab (REMICADE™) and etanercept (ENBREL™), most preferably adalimumab (HUMIRAT™). 
     In one embodiment, the TNFα inhibitor is an anti-tumor necrosis factor-alpha (TNFα) antibody, or antigen-binding portion thereof. For example, the anti-TNFα antibody, or antigen-binding portion thereof, can be a humanized antibody, a chimeric antibody or a multivalent antibody. 
     In another embodiment, the anti-TNFα antibody, or antigen-binding portion thereof, is a human antibody, preferably a human antibody, or antigen-binding portion thereof, that binds to human TNFα with high affinity and a low off rate, and has a high neutralizing capacity. Preferably, the human antibodies are recombinant, neutralizing human anti-hTNFα antibodies. The most preferred recombinant, neutralizing antibody used in the method of the invention is referred to herein as adalimumab, also referred to as HUMIRA® or D2E7 (the amino acid sequence of the adalimumab VL region is shown in SEQ ID NO: 303; the amino acid sequence of the adalimumab VH region is shown in SEQ ID NO: 304). The properties of D2E7 (adalimumab; Humira®) have been described in Salfeld et al., U.S. Pat. Nos. 6,090,382, 6,258,562, and 6,509,015, which are each incorporated by reference herein. 
     Other examples of TNFα antibodies include chimeric and humanized murine anti-hTNFα antibodies which have undergone clinical testing for treatment of rheumatoid arthritis (see e.g., Elliott et al. (1994)  Lancet  344:1125-1127; Elliot et al. (1994)  Lancet  344:1105-1110; Rankin et al. (1995)  Br. J. Rheumatol.  34:334-342). In another embodiment, the TNFα antibody used in the invention is infliximab (Remicade®, Johnson and Johnson; described in U.S. Pat. No. 5,656,272, incorporated by reference herein), CDP571 (a humanized monoclonal anti-TNF-alpha IgG4 antibody), CDP 870 (a humanized monoclonal anti-TNF-alpha antibody fragment), an anti-TNF dAb (Peptech), and CNTO 148 (golimumab; Medarex and Centocor, see also WO 02/12502). 
     In one embodiment, the TNFα inhibitors used in the methods of the invention include adalimumab antibodies and antibody portions, adalimumab-related antibodies and antibody portions, adalimumab-related DVD-Ig or dual specific antibodies, and other human antibodies and antibody portions with equivalent properties to adalimumab, such as high affinity binding to hTNFα with low dissociation kinetics and high neutralizing capacity. In one embodiment, a treatment regimen of the invention provides treatment with an isolated human antibody, or an antigen-binding portion thereof, that dissociates from human TNFα with a K d  of 1×10 −8  M or less and a K off  rate constant of 1×10 −3  s −1  or less, both determined by surface plasmon resonance, and neutralizes human TNFα cytotoxicity in a standard in vitro L929 assay with an IC 50  of 1×10 −7  M or less. More preferably, the isolated human antibody, or antigen-binding portion thereof, dissociates from human TNFα with a K off  of 5×10 −4  s −1  or less, or even more preferably, with a K off  of 1×10 −4  s −1  or less. More preferably, the isolated human antibody, or antigen-binding portion thereof, neutralizes human TNFα cytotoxicity in a standard in vitro L929 assay with an IC 50  of 1×10 −8  M or less, even more preferably with an IC 50  of 1×10 −9  M or less and still more preferably with an IC 50  of 1×10 −10  M or less. In a preferred embodiment, the antibody is an isolated human recombinant antibody, or an antigen-binding portion thereof. 
     It is well known in the art that antibody heavy and light chain CDR3 domains play an important role in the binding specificity/affinity of an antibody for an antigen. Accordingly, in another aspect, the TNFα inhibitor used in the treatment method of the invention is a human anti-TNFα antibody that has slow dissociation kinetics for association with hTNFα and that has light and heavy chain CDR3 domains that structurally are identical to or related to those of adalimumab. Position 9 of the adalimumab VL CDR3 can be occupied by Ala or Thr without substantially affecting the K off . Accordingly, a consensus motif for the adalimumab VL CDR3 comprises the amino acid sequence: Q-R-Y-N-R-A-P-Y-(T/A) (SEQ ID NO: 305). Additionally, position 12 of the adalimumab VH CDR3 can be occupied by Tyr or Asn, without substantially affecting the K off . Accordingly, a consensus motif for the adalimumab VH CDR3 comprises the amino acid sequence: V-S-Y-L-S-T-A-S-S-L-D-(Y/N) (SEQ ID NO: 306). Moreover, as demonstrated in Example 2 of U.S. Pat. No. 6,090,382, the CDR3 domain of the adalimumab heavy and light chains is amenable to substitution with a single alanine residue (at position 1, 4, 5, 7 or 8 within the VL CDR3 or at position 2, 3, 4, 5, 6, 8, 9, 10 or 11 within the VH CDR3) without substantially affecting the K off . Still further, the skilled artisan will appreciate that, given the amenability of the adalimumab VL and VH CDR3 domains to substitutions by alanine, substitution of other amino acids within the CDR3 domains may be possible while still retaining the low off rate constant of the antibody, in particular substitutions with conservative amino acids. Preferably, no more than one to five conservative amino acid substitutions are made within the adalimumab VL and/or VH CDR3 domains. More preferably, no more than one to three conservative amino acid substitutions are made within the adalimumab VL and/or VH CDR3 domains. Additionally, conservative amino acid substitutions should not be made at amino acid positions critical for binding to hTNFα. Positions 2 and 5 of the adalimumab VL CDR3 and positions 1 and 7 of the adalimumab VH CDR3 appear to be critical for interaction with hTNFα and thus, conservative amino acid substitutions preferably are not made at these positions (although an alanine substitution at position 5 of the adalimumab VL CDR3 is acceptable, as described above) (see U.S. Pat. No. 6,090,382). 
     Accordingly, in another embodiment, the antibody or antigen-binding portion thereof preferably contains the following characteristics: 
     a) dissociates from human TNFα with a K off  rate constant of 1×10 −3  s −1  or less, as determined by surface plasmon resonance; 
     b) has a light chain CDR3 domain comprising the amino acid sequence of SEQ ID NO: 305, or modified from SEQ ID NO: 305 by a single alanine substitution at position 1, 4, 5, 7 or 8 or by one to five conservative amino acid substitutions at positions 1, 3, 4, 6, 7, 8 and/or 9; 
     c) has a heavy chain CDR3 domain comprising the amino acid sequence of SEQ ID NO: 306, or modified from SEQ ID NO: 306 by a single alanine substitution at position 2, 3, 4, 5, 6, 8, 9, 10 or 11 or by one to five conservative amino acid substitutions at positions 2, 3, 4, 5, 6, 8, 9, 10, 11 and/or 12. 
     More preferably, the antibody, or antigen-binding portion thereof, dissociates from human TNFα with a K off  of 5×10 −4  s −1  or less. Even more preferably, the antibody, or antigen-binding portion thereof, dissociates from human TNFα with a K off  of 1×10 −4  s −1  or less. 
     In yet another embodiment, the antibody or antigen-binding portion thereof preferably contains a light chain variable region (LCVR) having a CDR3 domain comprising the amino acid sequence of SEQ ID NO: 305, or modified from SEQ ID NO: 305 by a single alanine substitution at position 1, 4, 5, 7 or 8, and with a heavy chain variable region (HCVR) having a CDR3 domain comprising the amino acid sequence of SEQ ID NO: 306, or modified from SEQ ID NO: 306 by a single alanine substitution at position 2, 3, 4, 5, 6, 8, 9, 10 or 11. Preferably, the LCVR further has a CDR2 domain comprising the amino acid sequence of SEQ ID NO: 307 (i.e., the adalimumab VL CDR2) and the HCVR further has a CDR2 domain comprising the amino acid sequence of SEQ ID NO: 308 (i.e., the adalimumab VH CDR2). Even more preferably, the LCVR further has CDR1 domain comprising the amino acid sequence of SEQ ID NO: 309 (i.e., the adalimumab VL CDR1) and the HCVR has a CDR1 domain comprising the amino acid sequence of SEQ ID NO: 310 (i.e., the adalimumab VH CDR1). The framework regions for VL preferably are from the V κ I human germline family, more preferably from the A20 human germline Vk gene and most preferably from the adalimumab VL framework sequences shown in FIGS. 1A and 1B of U.S. Pat. No. 6,090,382. The framework regions for VH preferably are from the V H 3 human germline family, more preferably from the DP-31 human germline VH gene and most preferably from the adalimumab VH framework sequences shown in FIGS. 2A and 2B of U.S. Pat. No. 6,090,382. 
     Accordingly, in another embodiment, the antibody or antigen-binding portion thereof preferably contains a light chain variable region (LCVR) comprising the amino acid sequence of SEQ ID NO: 303 (i.e., the adalimumab VL) and a heavy chain variable region (HCVR) comprising the amino acid sequence of SEQ ID NO: 304 (i.e., the adalimumab VH). In certain embodiments, the antibody comprises a heavy chain constant region, such as an IgG1, IgG2, IgG3, IgG4, IgA, IgE, IgM or IgD constant region. Preferably, the heavy chain constant region is an IgG1 heavy chain constant region or an IgG4 heavy chain constant region. Furthermore, the antibody can comprise a light chain constant region, either a kappa light chain constant region or a lambda light chain constant region. Preferably, the antibody comprises a kappa light chain constant region. Alternatively, the antibody portion can be, for example, a Fab fragment or a single chain Fv fragment. 
     In other embodiments, the TNFα inhibitor of the invention is etanercept (described in WO 91/03553 and WO 09/406,476), infliximab (described in U.S. Pat. No. 5,656,272), CDP571 (a humanized monoclonal anti-TNF-alpha IgG4 antibody), CDP 870 (a humanized monoclonal anti-TNF-alpha antibody fragment), D2E7 (a human anti-TNF mAb), soluble TNF receptor Type I, or a pegylated soluble TNF receptor Type I (PEGs TNF-R1). 
     The TNFα antibody of the invention can be modified. In some embodiments, the TNFα antibody or antigen binding fragments thereof, is chemically modified to provide a desired effect. For example, pegylation of antibodies and antibody fragments of the invention may be carried out by any of the pegylation reactions known in the art, as described, for example, in the following references:  Focus on Growth Factors  3:4-10 (1992); EP 0 154 316; and EP 0 401 384 (each of which is incorporated by reference herein in its entirety). Preferably, the pegylation is carried out via an acylation reaction or an alkylation reaction with a reactive polyethylene glycol molecule (or an analogous reactive water-soluble polymer). A preferred water-soluble polymer for pegylation of the antibodies and antibody fragments of the invention is polyethylene glycol (PEG). As used herein, “polyethylene glycol” is meant to encompass any of the forms of PEG that have been used to derivatize other proteins, such as mono (C1-C10) alkoxy- or aryloxy-polyethylene glycol. 
     Methods for preparing pegylated antibodies and antibody fragments of the invention will generally comprise the steps of (a) reacting the antibody or antibody fragment with polyethylene glycol, such as a reactive ester or aldehyde derivative of PEG, under conditions whereby the antibody or antibody fragment becomes attached to one or more PEG groups, and (b) obtaining the reaction products. It will be apparent to one of ordinary skill in the art to select the optimal reaction conditions or the acylation reactions based on known parameters and the desired result. 
     In yet another embodiment of the invention, TNFα antibodies or fragments thereof can be altered wherein the constant region of the antibody is modified to reduce at least one constant region-mediated biological effector function relative to an unmodified antibody. To modify an antibody of the invention such that it exhibits reduced binding to the Fc receptor, the immunoglobulin constant region segment of the antibody can be mutated at particular regions necessary for Fc receptor (FcR) interactions (see e.g., Canfield, S. M. and S. L. Morrison (1991)  J. Exp. Med.  173:1483-1491; and Lund, J. et al. (1991)  J. Immunol.  147:2657-2662). Reduction in FcR binding ability of the antibody may also reduce other effector functions which rely on FcR interactions, such as opsonization and phagocytosis and antigen-dependent cellular cytotoxicity. 
     An antibody or antibody portion of the invention can be derivatized or linked to another functional molecule (e.g., another peptide or protein). Accordingly, the antibodies and antibody portions of the invention are intended to include derivatized and otherwise modified forms of the anti-TNFα antibodies described herein, including immunoadhesion molecules. For example, an antibody or antibody portion of the invention can be functionally linked (by chemical coupling, genetic fusion, noncovalent association or otherwise) to one or more other molecular entities, such as another antibody (e.g., a bispecific antibody or a diabody), a detectable agent, a cytotoxic agent, a pharmaceutical agent, and/or a protein or peptide that can mediate associate of the antibody or antibody portion with another molecule (such as a streptavidin core region or a polyhistidine tag). 
     One type of derivatized antibody is produced by crosslinking two or more antibodies (of the same type or of different types, e.g., to create bispecific antibodies). Suitable crosslinkers include those that are heterobifunctional, having two distinctly reactive groups separated by an appropriate spacer (e.g., m-maleimidobenzoyl-N-hydroxysuccinimide ester) or homobifunctional (e.g., disuccinimidyl suberate). Such linkers are available from Pierce Chemical Company, Rockford, Ill. 
     Useful detectable agents with which an antibody or antibody portion of the invention may be derivatized include fluorescent compounds. Exemplary fluorescent detectable agents include fluorescein, fluorescein isothiocyanate, rhodamine, 5-dimethylamine-1-napthalenesulfonyl chloride, phycoerythrin and the like. An antibody may also be derivatized with detectable enzymes, such as alkaline phosphatase, horseradish peroxidase, glucose oxidase and the like. When an antibody is derivatized with a detectable enzyme, it is detected by adding additional reagents that the enzyme uses to produce a detectable reaction product. For example, when the detectable agent horseradish peroxidase is present, the addition of hydrogen peroxide and diaminobenzidine leads to a colored reaction product, which is detectable. An antibody may also be derivatized with biotin, and detected through indirect measurement of avidin or streptavidin binding. 
     Selection of the particular parameters of the treatment regimen can be based on known treatment parameters for the TNFα inhibitor previously established in the art. For example, a non-limiting example of a treatment regimen for adalimumab (HUMIRA™) is 40 mg every other week by subcutaneous injection. A non-limiting example of a treatment regimen for etanercept (ENBREL™) is 50 mg/week by subcutaneous injection. A non-limiting example of a treatment regimen for infliximab (REMICADE™) is 3 mg/kg by intravenous infusion at weeks 0, 2 and 6, then every 8 weeks. A treatment regimen can include administration of the TNFα inhibitor alone or can include combination of the TNFα inhibitor with other therapeutic agents, such as methotrexate (e.g., 10-20 mg/week) or prednisolone (e.g., 10 mg/week). Other suitable treatment regimens for the TNFα inhibitors discussed herein will be readily apparent to the ordinarily skilled artisan based on prior studies of preferred administration parameters for the TNFα inhibitor. 
     For administration to a subject, a TNFα inhibitor typically is formulated into a pharmaceutical composition containing the TNFα inhibitor and a pharmaceutically acceptable carrier. Therapeutic compositions typically must be sterile and stable under the conditions of manufacture and storage. Pharmaceutical compositions also can be administered in combination therapy, i.e., combined with other agents, such as other TNFα inhibitors and/or other therapeutic agents, such as traditional therapeutic agents for the treatment of autoimmune disorders, such as rheumatoid arthritis. 
     As used herein, “pharmaceutically acceptable carrier” includes any and all solvents, dispersion media, coatings, antibacterial and antifungal agents, isotonic and absorption delaying agents, and the like that are physiologically compatible. Preferably, the carrier is suitable for intravenous, intramuscular, subcutaneous, parenteral, spinal or epidermal administration (e.g., by injection or infusion). Depending on the route of administration, the active compound may be coated in a material to protect the compound from the action of acids and other natural conditions that may inactivate the compound. 
     The pharmaceutical compositions may include one or more pharmaceutically acceptable salts. A “pharmaceutically acceptable salt” refers to a salt that retains the desired biological activity of the parent compound and does not impart any undesired toxicological effects (see e.g., Berge, S. M., et al. (1977)  J. Pharm. Sci.  66:1-19). Examples of such salts include acid addition salts and base addition salts. Acid addition salts include those derived from nontoxic inorganic acids, such as hydrochloric, nitric, phosphoric, sulfuric, hydrobromic, hydroiodic, phosphorous and the like, as well as from nontoxic organic acids such as aliphatic mono- and dicarboxylic acids, phenyl-substituted alkanoic acids, hydroxy alkanoic acids, aromatic acids, aliphatic and aromatic sulfonic acids and the like. Base addition salts include those derived from alkaline earth metals, such as sodium, potassium, magnesium, calcium and the like, as well as from nontoxic organic amines, such as N,N′-dibenzylethylenediamine, N-methylglucamine, chloroprocaine, choline, diethanolamine, ethylenediamine, procaine and the like. 
     A pharmaceutical composition also may include a pharmaceutically acceptable anti-oxidant. Examples of pharmaceutically acceptable antioxidants include: (1) water soluble antioxidants, such as ascorbic acid, cysteine hydrochloride, sodium bisulfate, sodium metabisulfite, sodium sulfite and the like; (2) oil-soluble antioxidants, such as ascorbyl palmitate, butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), lecithin, propyl gallate, alpha-tocopherol, and the like; and (3) metal chelating agents, such as citric acid, ethylenediamine tetraacetic acid (EDTA), sorbitol, tartaric acid, phosphoric acid, and the like. 
     Examples of suitable aqueous and nonaqueous carriers that may be employed in the pharmaceutical compositions include water, ethanol, polyols (such as glycerol, propylene glycol, polyethylene glycol, and the like), and suitable mixtures thereof, vegetable oils, such as olive oil, and injectable organic esters, such as ethyl oleate. Proper fluidity can be maintained, for example, by the use of coating materials, such as lecithin, by the maintenance of the required particle size in the case of dispersions, and by the use of surfactants. 
     These compositions may also contain adjuvants such as preservatives, wetting agents, emulsifying agents and dispersing agents. Prevention of presence of microorganisms may be ensured both by sterilization procedures and by the inclusion of various antibacterial and antifungal agents, for example, paraben, chlorobutanol, phenol sorbic acid, and the like. It may also be desirable to include isotonic agents, such as sugars, sodium chloride, and the like into the compositions. In addition, prolonged absorption of the injectable pharmaceutical form may be brought about by the inclusion of agents which delay absorption such as aluminum monostearate and gelatin. 
     Pharmaceutically acceptable carriers include sterile aqueous solutions or dispersions and sterile powders for the extemporaneous preparation of sterile injectable solutions or dispersion. The use of such media and agents for pharmaceutically active substances is known in the art. Except insofar as any conventional media or agent is incompatible with the active compound, use thereof in the pharmaceutical compositions of the invention is contemplated. Supplementary active compounds can also be incorporated into the compositions. 
     A TNFα inhibitor of the present invention can be administered via one or more routes of administration using one or more of a variety of methods known in the art. As will be appreciated by the skilled artisan, the route and/or mode of administration will vary depending upon the desired results. A preferred route of administration, particularly for antibody agents, is by intravenous injection or infusion. Other preferred routes of administration include intramuscular, intradermal, intraperitoneal, subcutaneous, spinal or other parenteral routes of administration, for example by injection or infusion. The phrase “parenteral administration” as used herein means modes of administration other than enteral and topical administration, usually by injection, and includes, without limitation, intravenous, intramuscular, intraarterial, intrathecal, intracapsular, intraorbital, intracardiac, intradermal, intraperitoneal, transtracheal, subcutaneous, subcuticular, intraarticular, subcapsular, subarachnoid, intraspinal, epidural and intrasternal injection and infusion. Alternatively, a TNFα inhibitor of the invention can be administered via a non-parenteral route, such as a topical, epidermal or mucosal route of administration, for example, intranasally, orally, vaginally, rectally, sublingually or topically. 
     In a preferred embodiment, the subject to be treated with the TNFα inhibitor is a human subject. 
     A preferred autoimmune disorder in which to apply the methods of the invention for selecting and using a treatment regimen is rheumatoid arthritis. However, these methods can be applied to essentially any autoimmune disorder in which TNFα inhibitor therapy is applied, including the autoimmune disorders listed in the previous sections 
     Kits of the Invention 
     In another aspect, the invention pertains to kits for carrying out the methods of the invention. For example, in one embodiment, the invention provides a kit for predicting responsiveness to a TNFα inhibitor in a subject having an autoimmune disorder. In one embodiment, the kit comprises: 
     a) means for isolating monocytes; 
     b) means for measuring expression in the subject of one or more biomarkers predictive of responsiveness to a TNFα inhibitor in an autoimmune disorder; 
     c) means for measuring expression of at least one housekeeping gene; and 
     d) instructions for use of the kit to predicting responsiveness to a TNFα inhibitor in a subject having an autoimmune disorder, wherein the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-82 (or the biomarkers set forth by name in Table 9, as described above) 
     In one embodiment of the kit, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 6, 7, 10, 15-17, 19, 22, 24, 27, 31, 34-39, 43-47, 49, 51, 54, 55, 57, 59, 61, 62, 64, 70, 75, 79 and 82 (or the biomarkers set forth by name in Table 9 as being increased in ≧80% of responders vs. non-responders, as described above), more preferably the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 31, 37, 44, 47, 62 and 70 (or the biomarkers set forth by name in Table 9 as being increased in ≧90% of responders vs. non-responders, as described above), and even more preferably at least one of the biomarkers is encoded by a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO: 44 (or the CD11c biomarkers set forth by name in Table 9 as being increased in 100% of responders vs. non-responders). In each of these embodiments, preferably the instructions for use of the kit instruct that increased expression of the one or more biomarkers is predictive of responsiveness of the subject to a TNFα inhibitor. 
     In another embodiment of the kit, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 1-5, 8, 9, 11-14, 18, 20, 21, 23, 25, 26, 28-30, 32, 33, 40-42, 48, 50, 52, 53, 56, 58, 60, 63, 65-69, 71-74, 76-78, 80 and 81 (or the biomarkers set forth by name in Table 9 as being decreased in ≧80% of responders vs. non-responders, as described above), more preferably the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 11, 29, 65, 73 and 74 (or the biomarkers set forth by name in Table 9 as being decreased in ≧90% of responders vs. non-responders, as described above), and even more preferably the one or more biomarkers is encoded by a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO: 11 or SEQ ID NO: 74 (or the biomarkers set forth by name in Table 9 as being decreased in 100% of responders vs. non-responders, as described above). In each of these embodiments, preferably the instructions for use of the kit instruct that decreased expression of the one or more biomarkers is predictive of responsiveness of the subject to a TNFα inhibitor. 
     In another embodiment of the kit, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 83-133 (or the biomarkers set forth by name in Table 3, as described above). 
     In yet another embodiment of the kit, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 134-177, 110, 112, 118, 123 and 131 (or the biomarkers set forth by name in Table 4, as described above), more preferably SEQ ID NO: 134-150, 112, 118 (or the biomarkers set forth by name in Table 4 as being upregulated, as described above), wherein the instructions instruct that expression of the one or more biomarkers is increased in the subject, and/or more preferably SEQ ID NO: 151-177, 110 and 123 (or the biomarkers set forth by name in Table 4 as being downregulated, as described above), wherein the instructions instruct that expression of the one or more biomarkers is decreased in the subject. 
     In yet another embodiment of the kit, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 178-292, 91 and 97 (or the biomarkers set forth by name in Table 5, as described above), more preferably SEQ ID NO: 178-185; 187-200, 202, 203, 205-207; 211, 213, 214, 216, 220, 221, 226, 228, 229, 231, 232, 234, 235, 238-247, 249, 250, 253, 262-265, 268-282 and 285-288 (or the biomarkers set forth by name in Table 5 as being upregulated, as described above), wherein the instructions instruct that expression of the one or more biomarkers is increased in the subject, and/or more preferably SEQ ID NO: 186, 201, 204, 208, 209, 91, 210, 212, 97, 215, 217-219, 222-225, 227, 230, 233, 236, 237, 248, 251, 252, 254-261, 266, 267, 283, 284 and 289-292 (or the biomarkers set forth by name in Table 5 as being downregulated, as described above), wherein the instructions instruct that expression of the one or more biomarkers is decreased in the subject. 
     In yet another embodiment of the kit, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 87, 97, 101, 293, 92, 272, 93, 107, 108, 121 and 123 (or the biomarkers set forth by name in Table 6 as pre-treatment biomarkers, as described above), wherein the instructions instruct that the subject is monitored prior to treatment with a TNFα inhibitor. In yet another embodiment of the kit, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 290, 209, 98, 112, 116, 121, 130, 155, 92, 289, 216 and 131 (or the biomarkers set forth by name in Table 6 as post-treatment biomarkers, as described above), wherein the instructions instruct that the subject is monitored after treatment with a TNFα inhibitor. 
     In yet another embodiment of the kit, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 97, 102, 29, 294, 295, 91, 131, 290, 100, 134, 296, 297, 298, 299, 136, 174 and 300 (or the biomarkers set forth by name in Table 7, as described above). 
     In a preferred embodiment, the means for measuring expression in the subject of the one or more biomarkers predictive of responsiveness to a TNFα inhibitor in an autoimmune disorder comprises a nucleic acid preparation sufficient to detect expression of mRNA encoding the one or more biomarkers in a sample from the subject, such as a peripheral blood mononuclear cell sample from which mRNA is obtained by standard methods. This nucleic acid preparation includes at least one, and may include more than one, nucleic acid probe or primer, the sequence(s) of which is designed such that the nucleic acid preparation can detect the expression of mRNA encoding the biomarker(s) of interest in the sample from the subject. A preferred nucleic acid preparation includes two or more PCR primers that allow for PCR amplification of a segment of the mRNA encoding the biomarker(s) of interest. In a particularly preferred embodiment, the kit comprises a nucleic acid preparation sufficient to detect expression of CD11c mRNA in a sample from the subject. 
     Alternatively, the means for detecting expression in the subject of one or more biomarkers predictive of responsiveness to a TNFα inhibitor in an autoimmune disorder can comprise a reagent that detects the gene product of the mRNA encoding the biomarker(s) of interest sufficient to distinguish it from other gene products in a sample from the subject. A non-limiting example of such a reagent is a monoclonal antibody preparation (comprising one or more monoclonal antibodies) sufficient to detect protein expression of the biomarker(s) of interest in a sample from the subject, such as a peripheral blood mononuclear cell sample. In a particularly preferred embodiment, the kit comprises a monoclonal antibody preparation sufficient to detect expression of CD11c protein in a sample from the subject. 
     The means for measuring expression of the one or more biomarkers can also include, for example, buffers or other reagents for use in an assay for evaluating biomarker expression (e.g., at either the mRNA or protein level). The instructions can be, for example, printed instructions for performing the assay for evaluating the expression of the one or more biomarkers. 
     In a preferred embodiment, the means for measuring expression of at least one housekeeping gene comprises a nucleic acid preparation sufficient to detect expression of mRNA of the housekeeping gene (e.g., GAPDH) in a sample from the subject, such as a peripheral blood mononuclear cell sample from which mRNA is obtained by standard methods. This nucleic acid preparation includes at least one, and may include more than one, nucleic acid probe or primer, the sequence(s) of which is designed such that the nucleic acid preparation can detect the expression of mRNA of the housekeeping gene(s) in the sample from the subject. A preferred nucleic acid preparation includes two or more PCR primers that allow for PCR amplification of a segment of the mRNA of the housekeeping gene(s). Alternatively, the means for detecting expression in the subject of at least one housekeeping gene can comprise a reagent that detects the gene product of housekeeping gene sufficient to distinguish it from other gene products in a sample from the subject. A non-limiting example of such a reagent is a monoclonal antibody preparation (comprising one or more monoclonal antibodies) sufficient to detect protein expression of housekeeping gene product in a sample from the subject, such as a peripheral blood mononuclear cell sample. 
     The means for isolating monocytes can comprise one or more reagents that can be used to separate monocytes from other cell types in a sample of peripheral blood mononuclear cells, for example by positive selection of the monocytes or by negative selection in which all other cell types other than monocytes are removed. In one embodiment, a reagent that binds CD14 on monocytes (e.g., an anti-CD14 antibody) is included in the kit as means to isolate monocytes via positive selection. Alternatively, in another embodiment, reagents such as those commercially available in the Monocyte Isolation Kit II (Miltenyi Biotec, Auburn, Calif.) can be used for negative selection, in which non-monocytes (T cells, B cells, NK cells, dendritic cells, basophils) are indirectly magnetically labeled using a cocktail of biotin-conjugated antibodies against CD3, CD7, CD16, CD19, CD56, CD123 and CD235a (Glycophorin A), as well as anti-biotin MicroBeads, and then highly pure unlabeled monocytes are obtained by depletion of the magnetically labeled cells. 
     In another embodiment, the kit can further comprise a TNFα inhibitor for treating an autoimmune disorder in the subject. Preferred TNFα inhibitors for use in the kit include the TNFα inhibitors described in detail above with respect to treatment regimens, in particular anti-TNFα antibodies such as adalimumab, infliximab and/or golimumab, and/or Ig fusion proteins such as etanercept. 
     Preferably, the kit is designed for use with a human subject. 
     Databases and Computer Programs 
     In another aspect, the invention pertains to methods of building a database for use in selecting an autoimmune disorder subject for treatment with a TNFα inhibitor, or for use in selecting or monitoring a treatment regimen in an autoimmune disorder subject. The method can comprise receiving, in a computer system, biomarker expression patterns from a plurality of subjects having an autoimmune disorder; and storing the biomarker expression pattern from each subject such that the biomarker expression pattern is associated with an identifier of the subject, wherein the biomarker expression pattern reports expression in the subject of one or more biomarkers encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-82 (or the biomarkers set forth by name in Table 9, as described above). The identifier of the subject can be, for example, the name of the subject or a numerical or symbolic identifier coded to the identity of the subject. The method can further comprise receiving, in the computer system, one or more treatment regimens for treatment of an autoimmune disorder in a subject such that the treatment regimen is associated with the biomarker expression pattern of the subject and the identifier of the subject. A user can enter the subject&#39;s biomarker expression pattern, and optionally the subject&#39;s treatment regimen(s), into the computer system. Alternatively, the subject&#39;s biomarker expression pattern can be received directly from equipment used in determining the expression of one or more biomarkers in a sample from the subject. 
     In another aspect, the invention provides a computer program product useful for building a database for use in selecting or monitoring an autoimmune disorder subject for treatment with a TNFα inhibitor. The computer program can contain executable instructions that when executed cause a processor to perform operations comprising: receiving, in a computer system, a biomarker expression pattern of a subject at one or more biomarkers predictive of responsiveness to a TNFα inhibitor in an autoimmune disorder; and storing the biomarker expression pattern such that the biomarker expression pattern is associated with an identifier of the subject, wherein the biomarker expression pattern reports expression in the subject of one or more biomarkers encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-82 (or the biomarkers set forth by name in Table 9, as described above). Optionally, the computer program can further cause the processor to perform an operation comprising: receiving, in the computer system, a treatment regimen for treatment of an autoimmune disorder in the subject such that the treatment regimen is associated with the biomarker expression pattern of the subject and the identifier of the subject. 
     In another aspect, the invention provides a method of selecting an autoimmune disorder subject for a treatment with a TNFα inhibitor. The method can comprise: (i) identifying, in a database comprising a plurality of autoimmune disorder subjects, a subject whose database entry is associated with a biomarker expression pattern that is predictive of responsiveness to treatment with a TNFα inhibitor, and (ii) selecting the subject for treatment with a TNFα inhibitor, wherein the biomarker expression pattern reports expression in the subject of one or more biomarkers encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-82 (or the biomarkers set forth by name in Table 9, as described above). The method can further comprise selecting a treatment regimen by identifying, in the database, a treatment regimen that has been associated with the biomarker expression pattern of the subject and with an identifier of the subject. 
     In yet another aspect, the invention provides a computer program product useful for identifying and/or selecting a subject for treatment with a TNFα inhibitor. The computer program can contain executable instructions that when executed cause a processor to perform operations comprising: (i) identifying, in a database including a plurality of autoimmune disorder subjects associated with biomarker expression patterns, a subject that is associated with a biomarker expression pattern that is predictive of responsiveness to treatment with a TNFα inhibitor; and (ii) outputting the identified subject as a subject to be treated with a TNFα inhibitor; wherein the biomarker expression pattern reports expression in the subject of one or more biomarkers encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NO: 1-82 (or the biomarkers set forth by name in Table 9, as described above). The computer program can further cause the processor to perform an operation comprising outputting a treatment regimen that is associated with the subject to be treated with the TNFα inhibitor. 
     In one embodiment of the above-described methods and computer program, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 6, 7, 10, 15-17, 19, 22, 24, 27, 31, 34-39, 43-47, 49, 51, 54, 55, 57, 59, 61, 62, 64, 70, 75, 79 and 82 (or the biomarkers set forth by name in Table 9 as being increased in ≧80% of responders vs. non-responders, as described above), more preferably the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 31, 37, 44, 47, 62 and 70 (or the biomarkers set forth by name in Table 9 as being increased in ≧90% of responders vs. non-responders, as described above), and even more preferably at least one of the biomarkers is encoded by a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO: 44 (or the biomarker, CD11c antigen, set forth by name in Table 9 as being increased in 100% of responders vs. non-responders, as described above). In each of these embodiments, increased expression of the one or more biomarkers is predictive of responsiveness of the subject to a TNFα inhibitor. 
     In another embodiment of the above-described methods and computer programs, the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 1-5, 8, 9, 11-14, 18, 20, 21, 23, 25, 26, 28-30, 32, 33, 40-42, 48, 50, 52, 53, 56, 58, 60, 63, 65-69, 71-74, 76-78, 80 and 81 (or the biomarkers set forth by name in Table 9 as being decreased in ≧80% of responders vs. non-responders, as described above), more preferably the one or more biomarkers is encoded by a nucleic acid molecule comprising a nucleotide sequence selected from the group consisting of SEQ ID NOs: 11, 29, 65, 73 and 74 (or the biomarkers set forth by name in Table 9 as being decreased in ≧90% of responders vs. non-responders, as described above), and even more preferably the one or more biomarkers is encoded by a nucleic acid molecule comprising the nucleotide sequence of SEQ ID NO: 11 or SEQ ID NO: 74 (or the biomarkers set forth by name in Table 9 as being decreased in 100% of responders vs. non-responders, as described above). In each of these embodiments, decreased expression of the one or more biomarkers is predictive of responsiveness of the subject to a TNFα inhibitor. 
     In another embodiment of the above-described methods and/or computer programs, the biomarker expression pattern(s) can be for one or more biomarkers selected from the group consisting of SEQ ID NO: 83-133 (or the biomarkers set forth by name in Table 3, as described above). 
     In yet another embodiment of the above-described methods and/or computer programs, the biomarker expression pattern(s) can be for one or more biomarkers selected from the group consisting of SEQ ID NO: 134-177, 110, 112, 118, 123 and 131 (or the biomarkers set forth by name in Table 4, as described above), more preferably SEQ ID NO: 134-150, 112, 118 (or the biomarkers set forth by name in Table 4 as having increased expression, as described above), wherein expression of the one or more biomarkers is increased in the subject, and/or more preferably SEQ ID NO: 151-177, 110 and 123 (or the biomarkers set forth by name in Table 4 as having decreased expression, as described above), wherein expression of the one or more biomarkers is decreased in the subject. 
     In yet another embodiment of the above-described methods and/or computer programs, the biomarker expression pattern(s) can be for one or more biomarkers selected from the group consisting of SEQ ID NO: 178-292, 91 and 97 (or the biomarkers set forth by name in Table 5, as described above), more preferably SEQ ID NO: 178-185; 187-200, 202, 203, 205-207; 211, 213, 214, 216, 220, 221, 226, 228, 229, 231, 232, 234, 235, 238-247, 249, 250, 253, 262-265, 268-282 and 285-288 (or the biomarkers set forth by name in Table 5 as having increased expression, as described above), wherein expression of the one or more biomarkers is increased in the subject, and/or more preferably SEQ ID NO: 186, 201, 204, 208, 209, 91, 210, 212, 97, 215, 217-219, 222-225, 227, 230, 233, 236, 237, 248, 251, 252, 254-261, 266, 267, 283, 284 and 289-292 (or the biomarkers set forth by name in Table 5 as having decreased expression, as described above), wherein expression of the one or more biomarkers is decreased in the subject. 
     In yet another embodiment of the above-described methods and/or computer programs, the biomarker expression pattern(s) can be for one or more biomarkers selected from the group consisting of SEQ ID NO: 87, 97, 101, 293, 92, 272, 93, 107, 108, 121 and 123 (or the biomarkers set forth by name in Table 6 as pre-treatment biomarkers, as described above), wherein the subject is monitored prior to treatment with a TNFα inhibitor. In yet another embodiment of the above-described methods and/or computer programs, the biomarker expression pattern(s) can be for one or more biomarkers selected from the group consisting of SEQ ID NO: 290, 209, 98, 112, 116, 121, 130, 155, 92, 289, 216 and 131 (or the biomarkers set forth by name in Table 6 as post-treatment biomarkers, as described above), wherein the subject is monitored after treatment with a TNFα inhibitor. 
     In yet another embodiment of the above-described methods and/or computer programs, the biomarker expression pattern(s) can be for one or more biomarkers selected from the group consisting of SEQ ID NO: 97, 102, 29, 294, 295, 91, 131, 290, 100, 134, 296, 297, 298, 299, 136, 174 and 300 (or the biomarkers set forth by name in Table 7, as described above). 
     Computer systems and database software well established in the art can be adapted for use in the methods and computer program products of the invention for building and searching a database for use in selecting or monitoring a treatment regimen for a subject having an autoimmune disorder or for selecting a particular autoimmune disorder subject for treatment with a TNFα inhibitor. 
     The present invention is further illustrated by the following examples which should not be construed as further limiting. The contents of all references, patents and published patent applications cited throughout this application are expressly incorporated herein by reference in their entirety. 
     EXAMPLES 
     Example 1 
     Materials and Methodologies 
     In this example, the materials and methodologies used in the subsequent Examples are described. 
     Patients 
     Purified monocytes (MO) derived from a total of 84 RA patients were used. The clinical data for the RA patients, pre- and post-anti-TNFα treatment, is summarized in Table 1. All patients fulfilled the revised American College of Rheumatology (ACR) criteria (Arnett, F. C. et al. (1988)  Arthritis Rheum.  31:315-324). Patients were defined as responders (≧continuous ACR score 40) or non-responders (≦continuous ACR score 30) to anti-TNFα monotherapy, MTX monotherapy or combination therapy. In order to account for a gradual transition from clinical responders to non-responders to therapy, a continuous ACR response evaluation was performed by applying the ACR criteria, but by defining 10% response steps instead of the usual 20, 50, and 70% steps. This was also done to allow more detailed analyses of the correlation between the ACR response and the mRNA expression levels of the predictive marker CD11c. 
     For Affymetrix® microarray analysis, MO samples from 7 RA patients (RA1-RA7; all females) undergoing the Abbott DE011 trial were used (ReACT; monoclonal antibody Adalimumab®). In this multicenter, double-blinded study patients received Adalimumab® (20 mg weekly or 40 mg biweekly) in the outpatient Rheumatology Clinic of the Charite University Hospital in Berlin, Germany, for a total of 2 years. Non-steroidal anti-inflammatory drugs and 10 mg prednisolone-equivalent per week were allowed in addition to the anti-TNFα therapy. For TaqMan® real-time PCR, 26 patients (RA8-RA84 from the Abbott DE013 trial were used (ATTRACT). In this study Adalimumab®, methotrexate (MTX; 10-20 mg/week) or a combination of both therapeutics was applied. 
     The mean time interval between the two MO samples (blood sampling before and during therapy) was 9.4±1.8 months (mean±SEM; range 4-13.5 months), the mean age 50.3±3.9 years (range 39-70), and the mean disease duration 18.6±5.3 years (range 4-38). As controls, healthy individuals were recruited (n=7; 6 females, 1 male; mean age 36.1±7.4 years). RA patients RA1-RA84 were recruited from the Rheumatology Clinic of the Charité University Clinic, the Rheumaklinik of the Charité in Berlin-Buch, and from the Schlossparklinik in Berlin. 
     Separation of Peripheral Blood Mononuclear Cells, Purification of Monocytes, RNA Isolation 
     Peripheral blood (30 to 35 ml) was obtained by venopuncture, immediately stored in heparin-containing vacutainers (Beckton-Dickinson, Rutherford, N.J., USA), and cooled to 4° C. Blood samples were subjected to a Ficoll-Hypaque gradient (d=1.077 g/ml; Biochrom, Berlin, Germany). To enrich MO, negative selection magnetic cell sorting (MACS; Miltenyi; Bergisch Gladbach, Germany) was subsequently applied. Successful purification of MO (purity of 83-90%; 1.3-3.2×10 6  MO/patient) was validated by FACS analysis using CD14 and CD45 antibodies (Beckman-Coulter, Krefeld, Germany). In all cases, purified MO showed &gt;98% vitality using propidiumiodide staining (Pharmingen, San-Diego, Calif., USA). MO preparation was performed at 4° C. After purification, MO were lysed in RLT lysis buffer and total RNA was isolated using the RNeasy mini elute kit (Quiagen, Düsseldorf, Germany; yield 1.5-3.2 μg/sample). Quantification and quality control of RNA was performed at 260/280 nm using a Bioanalyzer 2100 unit (Agilent, Palo Alto, Calif., USA). 
     RNA Amplification and Labeling 
     For target synthesis, 500 ng of total RNA were amplified using the standard protocol of the manufacturer (Affymetrix®, Palo Alto, Calif., USA) and the Megascript kit (Ambion, Camhridgeshire, UK). 
     Biotin-Labeling of cRNA and Gene-Chip Hybridization 
     Biotinylated cRNA target was generated from amplified cRNAs using the Bioarray high-yield transcription kit (Enzo, New York, N.Y., USA). Samples were hybridized to Affymetrix® test and HG-U133A GeneChip arrays. 
     Following washing and staining, arrays were scanned twice at 3 μm resolution using a confocal scanner with an argon laser instrument (Agilent® G2500A GeneArray Scanner; Agilent, CA, USA). 
     Bioinformatic Analysis of Differentially Expressed Genes in ND and RA Patients Pre- and Post Anti-TNFα Treatment 
     All GeneChips were analyzed for signal calculation and pairwise comparisons using the GCOS 1.4 software package with standard settings provided by Affymetrix®. Scaling was performed to a target value of 150 and normalization was set to “1”. Pairwise comparison data were grouped to generate a percentage level of increased and decreased comparisons. Fold-changes were calculated from the mean of the SLR values in pairwise comparisons. Filtering was performed on the basis of “increased/decreased” comparisons with a percentage cutoff as indicated in the results. For hierarchical clustering, the software tool “Gene Expression Similarity Investigation Suite” (Genesis; Sturn, A. et al. (2002)  Bioinformatics  18:207-208; http://genome.tugraz.at/Software/GenesisCenter.html) was applied using normalized signal intensities, Pearson distance correlation, and complete linkage clustering. Prediction analysis was performed using the PAM software (http://www.bioconductor.org; Khan, J. et al. (2001)  Nat. Med.  7:673-679). 
     Data Sets of Publication 
     The complete ASCI-file datasets have been deposited in the microarray GEO database (http://www.ncbi.nlm.nih.gov/geo/). 
     TaqMan® Real Time PCR 
     Real-time PCR (RT-PC) was performed using a TaqMan® 7500 system and pre-designed TaqMan® low density gene expression primers (Applied Biosystems; Foster City, Calif., USA) or, in the case of CD11c, the primer Hs01015072_g1 (commercially available from Applied Biosystems) in a Bio-Rad iQ real time PCR system (Icycler; Bio-Rad; München, Germany). The housekeeping gene GAPDH was used for normalization of the cDNA content. Quantification was performed using the SDS 2.2.0 software (Applied Biosystems); results were expressed as relative quantities of the logarithm of the ΔΔCT values (log RQ), as the relative quantity of expression (RQ; fold-change in comparison to normal donor expression), or as the % expression as normalized to GAPDH. 
     Literature-Associated Pathway Analysis Using Ingenuity 
     Gene ontology and gene interaction analyses were executed using the Ingenuity® Pathway analysis tool v.4.0 (Ingenuity, Redwood City, Calif., USA; Jenssen, T. K. et al. (2001)  Nat. Genet.  28:21-28; http://www.ingenuity.com). Highest scoring neighborhood analysis of literature-based gene connections was performed by comparing up- and downregulated genes in anti-TNFα responders and non-responders (pre- and post-treatment). Significantly regulated genes in both comparisons were merged from the networks 1 to 5, complemented by transcription factors and finally overlayed with their relative expression values. 
     Expression-Based Pathway Analysis Using Kyoto Encyclopedia of Genes and Genomes (KEGG) 
     The KEGG pathway analysis (Kanehisa, M. and Bork, P. (2003)  Nat. Genet.  33:305-310) was performed using selected genes from the comparison of microarray data in responders and non-responders either pre- or post-treatment with anti-TNFα. Upregulated genes and downregulated genes within the illustrated pathways were color-coded in a gradient fashion (SLR 0.5 to ≧1.5). A total of 4 pathways out of the 8 most highly ranked pathways were selected for illustration. 
     Statistical Analysis 
     The non-parametric Mann-Whitney U test was applied to analyze differences between data from RA patients and normal donors, from untreated and anti-TNFα-treated RA patients, and from responders and non-responders to anti-TNFα-therapy. Correlation analyses between experimental and clinical/laboratory parameters of the patients were performed using the Pearson test and the software SPSS 13.0™ (SPSS Inc., Chicago, Ill., USA). For the U test, statistically significant differences were accepted for P≦0.05; for correlation analyses, the acceptance level was reduced to P≦0.01 to account for multiple comparisons. 
     Example 2 
     Clinical and Laboratory Assessments for RA Patients and Normal Donors 
     Two of the seven anti-TNFα-treated RA patients used for microarray analysis, i.e., patients RA4 and RA6, were non-responders to therapy according to the ACR improvement criteria (≦continuous ACR 30 score). In general, this was also reflected in the respective percent-reduction of other clinical parameters of local or systemic inflammation. The group of seven RA patients employed for microarray analysis in the present study constituted a representative RA cohort, as demonstrated by well-known correlations among clinical parameters pre- and post-anti-TNFα treatment, as summarized in Table 2. 
     The identification of patients RA4 and RA6 as non-responders was also confirmed by hierarchical clustering of clinical parameters. 
     Example 3 
     Gene Expression Profiling and Analysis 
     Differential Gene Expression in Responders Versus Non-Responders to Anti-TNFα-Therapy 
     A total of 119 differentially-expressed genes was identified by comparing RA and normal donors (ND; n=7 each; total of 49 comparisons). Hierarchical clustering of ND, as well as RA patients pre- and post-treatment with these genes also identified 5 responders and 2 non-responders (RAantiTNF4 and RAantiTNF6). 
     In order to select therapeutically relevant genes, a subpopulation of 51 differentially-expressed genes was then identified by the simultaneous comparison between RA versus normal donors (ND; total of 49 comparisons) and RA responders (n=5) pre- versus post-anti-TNFα therapy (25 comparisons). These genes showed an increase or decrease of the signal log ratio (SLR; between −4.36 and 4.61) in &gt;70% of the pair-wise comparisons between RA and ND. These genes are summarized in Table 3. 
     Hierarchical clustering with these genes resulted in precise (100%) classification of ND, RA patients pre-treatment, and clinically-defined responders (≧continuous ACR score 40; clustered as ND) or non-responders (≦continuous ACR score 30; clustered as RA; note RAantiTNF4 and RAantiTNF6). This was confirmed by supervised pattern discovery using prediction analysis of microarrays (PAM analysis) at a threshold value of 4.3 in order to minimize the misclassification error. Table 4 summarizes the results of the PAM analysis, showing 49 selected genes, five of them overlapping with genes listed in Table 3. In this case, both non-responders (RAantiTNF4 and RAantiTNF6) were classified as RA patients, whereas the responders, RAantiTNF1-3, RAantiTNF5, and RAantiTNF7, were classified either as normals or as anti-TNFα-treated RA patients. Notably, ND showed the lowest misclassification error at the threshold value (0.00; i.e., the highest similarity among individuals), followed by pre-treatment RA patients (0.14), and anti-TNFα-treated RA patients (0.42). 
     Identification of responders/non-responders was also confirmed by hierarchical clustering of RA patients post-treatment. A total of 117 genes differentially expressed in RA responders versus RA non-responders was identified in post-anti-TNFα therapy samples, which showed an increase or decrease in 100% of the respective pair-wise comparisons (total of 10 comparisons). The 117 genes identified in this analysis are summarized in Table 5, three of which genes overlap with the genes summarized in Table 3. Hierarchical clustering with these genes resulted in precise (100%) classification of responders and non-responders to therapy. 
     A number of the differentially-expressed genes showed highly significant correlations with clinical or laboratory parameters pre- and/or post-anti-TNFα treatment, indicating a potential clinical relevance of the genes and contributing to the selection of genes for validation with TaqMan® real-time RT-PCR. These genes are summarized in Table 6. 
     Example 4 
     Real-Time RT-PCR Validation of Genes Differentiating Responders and Non-Responders 
     Sixteen genes with a likely pathogenetic importance in RA (and 6 control genes) from Affymetrix® gene expression profiling were selected for validation by TaqMan® real-time RT-PCR (n=10 anti-TNFα-treated RA patients prior to therapy; n=14 ND). The RT-PCR results confirmed the results of Affymetrix® gene expression profiling for 17 of 22 genes (approx. 77%), summarized in Table 7. This applied to genes regarded as differentially expressed in RA versus ND by Affymetrix® analysis (decreased: &lt;−70%; increased: &gt;70%) and to equally expressed control genes. By real-time RT-PCR, 18 genes showed significantly differential expression (p≦0.000 for 7 genes; p≦0.041 for the remaining) in MO from RA patients responding to anti-TNFα therapy versus ND, including genes 10 upregulated in RA (Amphiregulin, Charcot-Leyden crystal protein, TNFα-induced protein 6, thrombomodulin, membrane-spanning 4-domains, subfamily A—member 4, S100 calcium binding protein A1, TNFα, IL-1β, lipoyltransferase 1, and interferon regulatory protein 1), as well as 8 genes downregulated in RA (Uncharacterized hypothalamus protein HT007, MHC class II HLA-DR-alpha, hypothetical protein L0054103, proteasome subunit beta type 7 precursor, protein KIAA0174, microsomal signal peptidase 18 kDa subunit, ring zinc finger protein 361, and protein phosphatase 1, catalytic subunit, beta isoform). However, the expression for these genes showed no significant differences for the direct comparison between RA responders and non-responders to anti-TNFα therapy. 
     The potential clinical relevance of some of the differentially expressed genes is underlined by a significant correlation with the ACR response at different time points during anti-TNFα therapy, as summarized in Table 8. 
     Validation of the 22 selected genes by TaqMan® real-time RT-PCR confirmed the results of Affymetrix® gene expression profiling for 17 of 22 genes (approx. 77% true positives or negatives), in accordance with the rates reported in other gene expression studies and therefore underlining the validity of the present data. The 18 genes showing significantly differential expression in MO from RA patients responding to anti-TNFα therapy versus ND included several genes with a likely pathogenetic importance in RA (e.g., amphiregulin, TNFα-induced protein 6, thrombomodulin, membrane-spanning 4-domains, subfamily A—member 4, S100 calcium binding protein A1, TNFα, IL-1β, lipoyltransferase 1, interferon regulatory protein 1, MHC class II HLA-DR-alpha). 
     Example 5 
     Gene Expression Profiling and Analysis 
     Differential Gene Expression in Responders Versus Non-Responders Prior to Anti-TNFα-Therapy (Predictive Genes) 
     Using a threshold of ≧80% for the pairwise comparisons between future RA responders and future RA non-responders prior to anti-TNFα therapy, a total of 82 predictive genes was identified (11 genes for a threshold of ≧90%; 3 genes for 100%). These genes are summarized in Table 9. The latter group (100%) consisted of 2 known proteins ( Homo sapiens  predicted osteoblast protein (GS3786); integrin alpha-X (antigen CD11c) and an unknown protein ( Homo sapiens  hypothetical protein FLJ10134). In particular the antigen CD11e appears highly interesting, since it is a surface molecule on human MO (and other cells of the myelomonocytic lineage), and since it has known inflammatory functions. Hierarchical clustering with the selected genes resulted again in precise (100%) predictive classification of future responders and non-responders to therapy. Marginal co-clustering of the patient RA5 with the non-responders RA4 and RA6 at the threshold values 80% and 100% possibly identified RA5 as a ‘weak’ responder, as also indicated by a marginal position in the hierarchical clustering of clinical parameters. 
     Interestingly, future responders to anti-TNFα-therapy (when directly compared to non-responders) showed a pattern shift from the recently described ‘inflammatory’ MO to ‘resident’ MO subsets (Gordon, S. et al. (2005)  Nat. Immunol.  5:953-963) both prior to therapy and post-treatment. Although most of the individual molecules showed an identical pattern shift in both pre-treatment and post-treatment comparisons, in particular the activating (CD16a,b) and inhibiting Fcγ-receptors (CD32) displayed an opposite behavior. This pattern shift was observed despite the fact that all pre-treatment or post-treatment comparisons between RA patients (all, future responders, future non-responders) and ND indicated a dominance of ‘inflammatory’ MO in the respective RA groups. Post-treatment, strikingly, responders to anti-TNFα-therapy became barely distinguishable from ND in contrast to non-responders, which still showed a clear ‘inflammatory’ predominance. These results indicate that successful anti-TNFα-therapy acts by blocking TNFα signaling via TNFα-receptors 1 and 2 and by subsequent induction of a major change in the composition of pro-inflammatory and other MO subsets. 
     Example 6 
     Real-Time RT-PCR Validation of Predictive CD11c 
     TaqMan® real-time RT-PCR confirmed the discrimination of future RA responders (n=15) from future nonresponders (n=12) to anti-TNF monotherapy (at the level of continuous ACR score 30) on the basis of their CD11c mRNA expression in monocytes. 
     TaqMan® real-time RT-PCR confirmed the separation of future RA responders n=55 from future non-responders n=12 to anti-TNFα monotherapy on the basis of their CD11c mRNA expression in MO. The results are summarized in the bar graph of  FIG. 1 . This clear separation was lost in the case of combination therapy with anti-TNFα/MTX, possibly due to a differential importance of the CD11c mRNA expression for the anti-TNFα and MTX components. 
     Of the 3 genes identified by pairwise comparison between RA responders and RA non-responders prior to treatment at the level of 100% (and confirmed by TaqMan® real-time RT-PCR), the antigen CD11c appears of particular interest, since it is expressed on the surface of human MO (and other cells of the myelomonocytic lineage, e.g. dendritic cells), and since it has known functions in inflammatory reactions (e.g., as the complement receptor 4) and cell adhesion. 
     The validity of CD11c as a predictive biomarker is further underlined by a significant correlation (r=0.651, P=&lt;0.0001, n=27) between the CD11c expression prior to therapy and the future percentage of the ACR response, illustrated in the graph of  FIG. 2 . 
     Except for 1 RA patient with a borderline ACR response of 30 and a CD11c mRNA level directly at the distinction threshold (who was therefore classified as a false negative), the threshold level (40%) almost fully distinguished future responders from nonresponders (100% specificity, 94% sensitivity, and 96% power). This clear separation was lost in the case of combination therapy with anti-TNF/methotrexate (MTX), possibly owing to a differential importance of the CD11c mRNA expression for the anti-TNF and MTX treatment components. This was further underlined by the fact that: i) future responders to MTX monotherapy did not significantly differ in their CD11c mRNA expression level from future nonresponders to MTX monotherapy; and ii) there was no significant correlation between the future ACR response of RA patients treated with MTX monotherapy and their CD11c mRNA expression (data not shown). 
     Strikingly, this was true not only for the continuous ACR score, but also for the clinically applied, discrete ACR criteria. 
     A significant correlation (r=0.656, P=&lt;0.0001, n=27) was observed between CD11c expression and the future percentage of strict ACR response, illustrated in the graph in  FIG. 3 . This finding complements and expands previous reports on the identification of molecules capable of predicting a future response to anti-TNFα therapy (Lequerre, T. et al. (2006)  Arthritis Res. Ther.  8:R105; Toh, M. L. et al. (2006)  Arthritis Rheum.  54:2109-2118). 
     Example 7 
     Ingenuity® Pathway Analysis 
     Ingenuity® pathway analysis of the genes in Tables 3 and 5 indicated a direct or indirect influence of anti-TNFα therapy on several molecules thought to be relevant for the pathogenesis and/or severity of RA, e.g., HLA-DMA/B (Morel, J. et al. (2004)  Ann. Rheum. Dis.  63:1581-1586), CD69 (Marzio, R. et al. (1999)  Immunopharmacol. Immunotoxicol.  2:565-582) thrombomodulin (Cobankara, V. et al. (2004)  Clin. Rheumatol.  23:430-434), membrane-spanning 4-domains, subfamily A—member 4 (Fujikado, N. et al. (2006)  Arthritis Res. Ther.  8:1-13), and forkhead box 03a (Jonsson, H. et al. (2005)  Nat. Med.  11:666-671). The present approach, therefore, represents a powerful tool to identify gene regulation patterns applicable for diagnosis, as well as for therapy stratification and monitoring in rheumatic diseases, in particular in view of the fact that blood MO are much more easily available than synovial tissue samples. This is further supported by the fact that a high number of individual genes show significant correlations with clinical parameters in RA patients pre- and/or post-anti-TNFα treatment (see Table 6). 
     Pairwise comparison between RA responders and RA non-responders prior to treatment yielded a number of genes suitable for the prediction of a future response to anti-TNFα therapy (82 genes for a threshold of ≧80%; 11 genes for ≧90%; 3 genes for 100%; summarized in Table 9), resulting in exact classification of future responders and non-responders upon hierarchical clustering. Using all genes differentially expressed in the above comparison at a threshold level of 70% (256 pre-treatment; 1295 post-treatment) for Ingenuity® pathway analysis, the differences between responders and non-responders either pre-treatment or post-treatment were concentrated in the functional gene ontology terms cellular movement, haematological system development, immune response, cell-to-cell signaling and interaction, as well as immunological disease. 
     In particular, numerous relevant mediators were identified: i) pro-inflammatory cytokines (e.g., interleukin-8 [IL8], chemokine (C—C motif) ligand 5 [CCL5], chemokine (C—X—C motif) ligand 5 [CXCL5], and chemokine (C—X—C motif) ligand 10 [CXCL10]); ii) pro-destructive enzymes (e.g., matrix metalloproteinase 9 [MMP9]); iii) adhesion molecules and Fcγ-receptors (galectin-8 [LGALS8], integrin alpha-X [ITGAX] or CD11c, Fc-gamma receptor IIb [FCGR2B] or CD32, CD86 [CD86] and platelet/endothelial cell adhesion molecule 1 [PECAM1] or CD31); iv) signal transduction molecules (e.g., protein kinase B [AKT1], apoptosis regulator Bel-2 [BCL2], p21-activated protein kinase 1 [PAK1]); and v) transcription factors (e.g., Mad-related protein 2 [SMAD2], interferon regulatory factor 1 [IRF1], c-myb [MYB], early growth response protein 1 [EGR1], signal transducer and activator of transcription 1 [STAT1], and nuclear factor NF-κB 1 [NFKB1]; for the remaining abbreviations see the respective gene cards [http://www.genecards.org/index.shtml]). These molecules were differentially expressed between RA responders and RA non-responders either pre-treatment or post-treatment and in some cases even inverted their expression upon anti-TNFα-therapy (see interleukin-8 receptor beta [IL8RB], Amyloid-beta A4 precursor [APP]; overexpressed in RA responders pre-treatment and underexpressed post-treatment). Similar opposite variations in transcript levels between RA responders and RA non-responders have recently been reported when comparing baseline to 3-month results (Lequerre, T. et al. (2006)  Arthritis Res. Ther.  8:R105). 
     Most strikingly, the transcription of TNFα itself, as well the transcription of members of the subsequent NFKB-pathway (NFKB1 and inhibitor of NF-κB [IKBKB]), was upregulated in RA responders post-treatment. This previously unreported finding at first sight questions the central pro-inflammatory role of TNFα in RA. However, several caveats should be considered: i) The mRNA expression levels of TNFα measured in the present study may not be proportional to the levels of circulating TNFα protein and/or bioactivity, the latter apparently predictive of the clinical response to TNFα inhibition (Marotte, H. et al. (2005)  Arthritis Res. Ther.  7:R149-155); ii) TNFα, in addition to its well-established pro-inflammatory properties, may also exhibit phase-dependent immunosuppressive properties (Kassiotis, G. et al. (2001)  J. Exp. Med.  193:427-434). 
     Several interesting pathways with potential importance for the mechanisms underlying susceptibility to anti-TNFα-therapy were identified by KEGG pathway analysis; including Apotosis and the MAPK pathways. 
     
       
         
           
               
             
               
                 TABLE 1 
               
               
                   
               
               
                 Clinical parameters of patients before and after anti-TNF treatment 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                   
                 Methods 
                 Duration 
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 Affymetrix (A) 
                 of 
                 Disease 
                   
                   
                   
                 Morning 
                 Swollen joint 
                 Painful joint 
               
               
                   
                 real-time 
                 treatment, 
                 duration, 
                 Age, 
                   
                   
                 stiffness, min 
                 count 68 
                 count 68 
               
               
                 Patient 
                 (R/P) 
                 mo 
                 y 
                 y 
                 Gender 
                 RF 
                 (% reduction) 
                 (% reduction) 
                 (% reduction) 
               
               
                   
               
               
                 RA1-1110006211 
                 A/P 
                 0 
                 4 
                 52 
                 F 
                 + 
                 320  
                 10 
                 19 
               
               
                 RA1-aTNF 
                 A 
                 13.5 
                   
                   
                   
                   
                 15 (95) 
                 3 (70) 
                  8 (58) 
               
               
                 RA2-1110005181 
                 A/P 
                 0 
                 9 
                 53 
                 F 
                 + 
                 180  
                 16 
                 50 
               
               
                 RA2-aTNF 
                 A 
                 6 
                   
                   
                   
                   
                  0 (100) 
                 1 (94) 
                 19 (62) 
               
               
                 RA3-1110005291 
                 A/P 
                 0 
                 18 
                 39 
                 F 
                 + 
                  0 
                 10 
                 28 
               
               
                 RA3-aTNF 
                 A 
                 5.5 
                   
                   
                   
                   
                 0 (0) 
                 2 (80) 
                  8 (29) 
               
               
                 RA4-1110005031 
                 A/P 
                 0 
                 12 
                 47 
                 F 
                 + 
                 720  
                 20 
                 43 
               
               
                 RA4-aTNF 
                 A 
                 17 
                   
                   
                   
                   
                 60 (92) 
                 19 (5)  
                 35 (19) 
               
               
                 RA5-1110004141 
                 A/P 
                 0 
                 38 
                 70 
                 F 
                 + 
                 120  
                 11 
                 56 
               
               
                 RA5-aTNF 
                 A 
                 15 
                   
                   
                   
                   
                 120 (0)  
                 2 (82) 
                 61 (0)  
               
               
                 RA6-1110004131 
                 A/P 
                 0 
                 38 
                 51 
                 F 
                 + 
                 60 
                 12 
                 27 
               
               
                 RA6-aTNF 
                 A 
                 4 
                   
                   
                   
                   
                 60 (0)  
                 4 (67) 
                 28 (0)  
               
               
                 RA7-1110006221 
                 A/P 
                 0 
                 11 
                 40 
                 F 
                 + 
                 150  
                 18 
                 44 
               
               
                 RA7-aTNF 
                 A 
                 4.5 
                   
                   
                   
                   
                 10 (93) 
                 5 (72) 
                 25 (43) 
               
               
                 RA8-06507 
                 R 
                 0 
                 &lt;1 
                 28 
                 F 
                 − 
                 120  
                 14 
                 17 
               
               
                 RA8-aTNF/MTX 
                 R 
                 6 
                   
                   
                   
                   
                  0 (100) 
                  0 (100) 
                  3 (82) 
               
               
                 RA9-06513 
                 R 
                 0 
                 1 
                 53 
                 F 
                 − 
                 120  
                 16 
                 20 
               
               
                 RA9-aTNF/MTX 
                 R 
                 4.5 
                   
                   
                   
                   
                 15 (87) 
                 12 (25)  
                 16 (20) 
               
               
                 RA10-05602 
                 R 
                 0 
                 1 
                 48 
                 F 
                 + 
                 180  
                  8 
                 40 
               
               
                 RA10-MTX 
                 R 
                 3.5 
                   
                   
                   
                   
                 240 (0)  
                 10 (0)  
                 29 (27) 
               
               
                 RA11-05610 
                 R/P 
                 0 
                 &lt;1 
                 38 
                 F 
                 − 
                 360  
                 14 
                 22 
               
               
                 RA11-aTNF 
                 R 
                 6 
                   
                   
                   
                   
                 30 (92) 
                 3 (79) 
                  9 (59) 
               
               
                 RA12-05609 
                 R/P 
                 0 
                 1 
                 63 
                 F 
                 + 
                 60 
                 17 
                 29 
               
               
                 RA12-aTNF 
                 R 
                 6 
                   
                   
                   
                   
                 10 (83) 
                 5 (71) 
                  9 (69) 
               
               
                 RA13-05608 
                 R 
                 0 
                 2 
                 44 
                 F 
                 + 
                 45 
                 12 
                 24 
               
               
                 RA13-aTNF/MTX 
                 R 
                 6 
                   
                   
                   
                   
                  0 (100) 
                  0 (100) 
                  1 (96) 
               
               
                 RA14-05612 
                 R/P 
                 0 
                 1 
                 29 
                 F 
                 + 
                 60 
                  8 
                 11 
               
               
                 RA14-aTNF/MTX 
                 R 
                 6 
                   
                   
                   
                   
                  0 (100) 
                  0 (100) 
                  0 (100) 
               
               
                 RA15-06504 
                 R/P 
                 0 
                 2 
                 47 
                 F 
                 + 
                 60 
                 10 
                 23 
               
               
                 RA15-aTNF 
                 R 
                 6 
                   
                   
                   
                   
                 20 (67) 
                 2 (80) 
                  3 (87) 
               
               
                 RA16-06308 
                 R/P 
                 0 
                 &lt;1 
                 60 
                 F 
                 + 
                 120  
                 17 
                 29 
               
               
                 RA16-aTNF/MTX 
                 R 
                 6 
                   
                   
                   
                   
                 15 (87) 
                 1 (94) 
                 16 (45) 
               
               
                 RA17-06516 
                 R 
                 0 
                 1 
                 36 
                 F 
                 + 
                 30 
                 17 
                 17 
               
               
                 RA11-aTNF 
                 R/P 
                 6 
                   
                   
                   
                   
                 15 (50) 
                 11 (35)  
                  0 (100) 
               
               
                 RA18-06309 
                 R 
                 0 
                 1 
                 83 
                 F 
                 − 
                 30 
                 11 
                 27 
               
               
                 RA18-aTNF/MTX 
                 R 
                 6 
                   
                   
                   
                   
                  0 (100) 
                  0 (100) 
                  0 (100) 
               
               
                 RA19-05613 
                 R/P 
                 0 
                 2 
                 63 
                 F 
                 + 
                 120  
                 25 
                 43 
               
               
                 RA19-aTNF 
                 R 
                 6 
                   
                   
                   
                   
                 15 (87) 
                 9 (64) 
                 17 (60) 
               
               
                 RA20-06304 
                 R/P 
                 0 
                 &lt;1 
                 50 
                 F 
                 − 
                 60 
                 12 
                 29 
               
               
                 RA20-aTNF 
                 R 
                 6 
                   
                   
                   
                   
                  0 (100) 
                 2 (83) 
                  5 (83) 
               
               
                 RA21-06514 
                 R/P 
                 0 
                 2 
                 56 
                 F 
                 − 
                 30 
                 21 
                 52 
               
               
                 RA21-aTNF/MTX 
                 R 
                 6 
                   
                   
                   
                   
                 30 (0)  
                 15 (29)  
                 16 (69) 
               
               
                 RA22-05606 
                 R/P 
                 0 
                 &lt;1 
                 36 
                 F 
                 + 
                 60 
                 12 
                 22 
               
               
                 RA22-aTNF/MTX 
                 R 
                 6 
                   
                   
                   
                   
                  0 (100) 
                 2 (83) 
                  9 (83) 
               
               
                 RA23-06306 
                 R/P 
                 0 
                 1 
                 34 
                 F 
                 + 
                 30 
                 13 
                 27 
               
               
                 RA23-aTNF 
                 R 
                 3 
                   
                   
                   
                   
                 30 (0)  
                 18 (0)  
                 27 (0)  
               
               
                 RA24-06305 
                 R 
                 0 
                 n.d. 
                 18 
                 F 
                 + 
                 30 
                 14 
                 20 
               
               
                 RA24-MTX 
                 R 
                 6 
                   
                   
                   
                   
                 60 (0)  
                 2 (86) 
                  8 (60) 
               
               
                 RA25-06515 
                 R/P 
                 0 
                 &lt;1 
                 54 
                 M 
                 − 
                 45 
                 22 
                 43 
               
               
                 RA25-aTNF 
                 R 
                 6 
                   
                   
                   
                   
                 20 (66) 
                 7 (68) 
                 28 (35) 
               
               
                 RA26-06506 
                 R/P 
                 0 
                 1 
                 50 
                 F 
                 − 
                 60 
                  9 
                 23 
               
               
                 RA26-aTNF 
                 R 
                 6 
                   
                   
                   
                   
                 120 (0)  
                 20 (0)  
                 45 (0)  
               
               
                 RA27-05601 
                 R/P 
                 0 
                 1 
                 42 
                 F 
                 + 
                 60 
                  8 
                 24 
               
               
                 RA27-aTNF 
                 R 
                 6.5 
                   
                   
                   
                   
                 60 (0)  
                 7 (12) 
                 30 (0)  
               
               
                 RA28-1110004171 
                 P 
                 0 
                 n.d. 
                 34 
                 F 
                 + 
                 60 
                 20 
                 47 
               
               
                 RA28-aTNF 
                   
                 3.5 
                   
                   
                   
                   
                  0 (100) 
                 4 (80) 
                  4 (91) 
               
               
                 RA29-1110011271 
                 P 
                 0 
                 11 
                 62 
                 F 
                 + 
                 120  
                  8 
                 35 
               
               
                 RA29-aTNF/MTX 
                   
                 0.5 
                   
                   
                   
                   
                 120 (0)  
                 9 (0)  
                 44 (0)  
               
               
                 RA30-1110010101 
                 P 
                 0 
                 7 
                 35 
                 F 
                 + 
                 120  
                  8 
                 12 
               
               
                 RA30-aTNF/MTX 
                   
                 10 
                   
                   
                   
                   
                  0 (100) 
                 2 (75) 
                  7 (42) 
               
               
                 RA31-1110004121 
                 P 
                 0 
                 13 
                 33 
                 F 
                 + 
                 30 
                 11 
                 27 
               
               
                 RA31-aTNF 
                   
                 6 
                   
                   
                   
                   
                 20 (67) 
                 2 (82) 
                  7 (74) 
               
               
                 RA32-1110008092 
                 P 
                 0 
                 20 
                 43 
                 F 
                 + 
                 60 
                 14 
                 38 
               
               
                 RA32-aTNF 
                   
                 6.5 
                   
                   
                   
                   
                  0 (100) 
                 6 (57) 
                  7 (72) 
               
               
                 RA33-1110005121 
                 P 
                 0 
                 8 
                 61 
                 F 
                 − 
                 180  
                 19 
                 59 
               
               
                 RA33-aTNF 
                   
                 17.5 
                   
                   
                   
                   
                 120 (66)  
                 2 (89) 
                 12 (81) 
               
               
                 RA34-1110111281 
                 P 
                 0 
                 12 
                 66 
                 F 
                 + 
                 90 
                 10 
                  5 
               
               
                 RA34-MTX 
                   
                 12 
                   
                   
                   
                   
                 120 (0)  
                 8 (20) 
                 9 (0) 
               
               
                 RA35-1110112121 
                 P 
                 0 
                 6 
                 63 
                 F 
                 + 
                 180  
                  8 
                 20 
               
               
                 RA35-MTX 
                   
                 9 
                   
                   
                   
                   
                  0 
                 3 (63) 
                  4 (80) 
               
               
                 RA36-1110201231 
                 P 
                 0 
                 10 
                 36 
                 F 
                 0 
                 60 
                 30 
                 19 
               
               
                 RA36-MTX 
                   
                 4 
                   
                   
                   
                   
                 30 (50) 
                  0 (100) 
                  0 (100) 
               
               
                 RA37-1110211051 
                 P 
                 0 
                 1 
                 59 
                 F 
                 + 
                 180  
                  2 
                 21 
               
               
                 RA37-MTX 
                   
                 3 
                   
                   
                   
                   
                 15 (92) 
                  0 (100) 
                  4 (81) 
               
               
                 RA38-1110309012 
                 P 
                 0 
                 &lt;1 
                 32 
                 F 
                 + 
                 180  
                  7 
                 29 
               
               
                 RA38-MTX 
                   
                 3 
                   
                   
                   
                   
                  0 (100) 
                 1 (85) 
                  3 (90) 
               
               
                 RA39-1110309122 
                 P 
                 0 
                 1 
                 26 
                 F 
                 + 
                 180  
                  6 
                 23 
               
               
                 RA39-MTX 
                   
                 3 
                   
                   
                   
                   
                 15 (92) 
                 1 (83) 
                  9 (41) 
               
               
                 RA40-1110310302 
                 P 
                 0 
                 1 
                 45 
                 F 
                 + 
                 10 
                 10 
                 17 
               
               
                 RA40-MTX 
                   
                 4 
                   
                   
                   
                   
                  0 (100) 
                  0 (100) 
                  2 (88) 
               
               
                 RA41-1110411251 
                 P 
                 0 
                 &lt;1 
                 58 
                 F 
                 0 
                 180 
                  6 
                 16 
               
               
                 RA41-MTX 
                   
                 3 
                   
                   
                   
                   
                  0 (100) 
                  0 (100) 
                  2 (88) 
               
               
                 RA42-1110409071 
                 P 
                 0 
                 1 
                 52 
                 F 
                 0 
                  0 
                  9 
                  4 
               
               
                 RA42-MTX 
                   
                 3 
                   
                   
                   
                   
                 0 (0) 
                  0 (100) 
                  0 (100) 
               
               
                 RA43-1110409141 
                 P 
                 0 
                 &lt;1 
                 58 
                 M 
                 + 
                 10 
                  8 
                 22 
               
               
                 RA43-MTX 
                   
                 3 
                   
                   
                   
                   
                 10 (0)  
                  0 (100) 
                  5 (77) 
               
               
                 RA44-1110409223 
                 P 
                 0 
                 1 
                 67 
                 F 
                 0 
                 60 
                 12 
                 20 
               
               
                 RA44-MTX 
                   
                 3 
                   
                   
                   
                   
                  0 (100) 
                  0 (100) 
                  4 (80) 
               
               
                 RA45-1110411291 
                 P 
                 0 
                 &lt;1 
                 44 
                 F 
                 0 
                 30 
                 25 
                 43 
               
               
                 RA45-MTX 
                   
                 3 
                   
                   
                   
                   
                  0 (100) 
                 9 (64) 
                 17 (60) 
               
               
                 RA46-1110602212 
                 P 
                 0 
                 10 
                 45 
                 F 
                 + 
                 120  
                  3 
                 13 
               
               
                 RA46-aTNF/MTX 
                   
                 6 
                   
                   
                   
                   
                 120 (0)  
                  0 (100) 
                 21 (0)  
               
               
                 RA47-1110503081 
                 P 
                 0 
                 21 
                 57 
                 F 
                 + 
                 360  
                  8 
                 10 
               
               
                 RA47-TNF 
                   
                 6 
                   
                   
                   
                   
                 180 (50)  
                 7 (14) 
                 11 (0)  
               
               
                 RA48-1110703082 
                 P 
                 0 
                 7 
                 60 
                 F 
                 + 
                 240  
                  0 
                 10 
               
               
                 RA48-TNF 
                   
                 6 
                   
                   
                   
                   
                 120 (50)  
                 0 (0)  
                  5 (50) 
               
               
                 RA49-1110309122 
                 P 
                 0 
                 1 
                 26 
                 F 
                 + 
                 180  
                  6 
                 24 
               
               
                 RA49-MTX 
                   
                 9 
                   
                   
                   
                   
                 15 (92) 
                 1 (83) 
                  9 (62) 
               
               
                 RA50-1100308202 
                 P 
                 0 
                 6 
                 63 
                 F 
                 + 
                  0 
                  0 
                 18 
               
               
                 RA50-MTX 
                   
                 3 
                   
                   
                   
                   
                 0 (0) 
                 1 (0)  
                  2 (89) 
               
               
                 RA51-1110309111 
                 P 
                 0 
                 2 
                 45 
                 M 
                 + 
                 180  
                 16 
                 30 
               
               
                 RA51-MTX 
                   
                 3 
                   
                   
                   
                   
                 120 (33)  
                 9 (44) 
                 24 (20) 
               
               
                 RA52-1110401081 
                 P 
                 0 
                 1 
                 62 
                 F 
                 + 
                  0 
                  0 
                 18 
               
               
                 RA52-MTX 
                   
                 5.5 
                   
                   
                   
                   
                 0 (0) 
                 0 (0)  
                  0 (100) 
               
               
                 RA53-1110406011 
                 P 
                 0 
                 1 
                 61 
                 F 
                 + 
                 30 
                 10 
                 33 
               
               
                 RA53-MTX 
                   
                 3 
                   
                   
                   
                   
                  5 (83) 
                  0 (100) 
                  1 (97) 
               
               
                 RA54-1110406112 
                 P 
                 0 
                 3 
                 61 
                 M 
                 + 
                 10 
                  6 
                 22 
               
               
                 RA54-MTX 
                   
                 3 
                   
                   
                   
                   
                  0 (100) 
                  0 (100) 
                  5 (77) 
               
               
                 RA55-1110406111 
                 P 
                 0 
                 &lt;1 
                 57 
                 F 
                 + 
                 60 
                  2 
                 12 
               
               
                 RA55-MTX 
                   
                 3 
                   
                   
                   
                   
                  0 (100) 
                  0 (100) 
                  2 (83) 
               
               
                 RA56-1110407131 
                 P 
                 0 
                 1 
                 63 
                 F 
                 + 
                 30 
                  9 
                 30 
               
               
                 RA56-MTX 
                   
                 3 
                   
                   
                   
                   
                  0 (100) 
                  0 (100) 
                  6 (80) 
               
               
                 RA57-1110407281 
                 P 
                 0 
                 2 
                 56 
                 F 
                 + 
                  0 
                  7 
                 19 
               
               
                 RA57-MTX 
                   
                 3 
                   
                   
                   
                   
                 0 (0) 
                  0 (100) 
                  2 (89) 
               
               
                 RA58-1110409201 
                 P 
                 0 
                 1 
                 61 
                 F 
                 + 
                 10 
                  5 
                 16 
               
               
                 RA58-MTX 
                   
                 3 
                   
                   
                   
                   
                  0 (100) 
                  0 (100) 
                  4 (75) 
               
               
                 RA59-1110410271 
                 P 
                 0 
                 6 
                 35 
                 M 
                 + 
                 15 
                  0 
                  5 
               
               
                 RA59-MTX 
                   
                 3 
                   
                   
                   
                   
                  0 (100) 
                 0 (0)  
                  2 (60) 
               
               
                 RA60-1110503231 
                 P 
                 0 
                 1 
                 71 
                 F 
                 + 
                 30 
                  6 
                 23 
               
               
                 RA60-MTX 
                   
                 3 
                   
                   
                   
                   
                  0 (100) 
                  0 (100) 
                  5 (78) 
               
               
                 RA61-1110504061 
                 P 
                 0 
                 1 
                 51 
                 F 
                 + 
                 45 
                 12 
                 27 
               
               
                 RA61-MTX 
                   
                 3 
                   
                   
                   
                   
                  0 (100) 
                  0 (100) 
                  0 (100) 
               
               
                 RA62-1110505301 
                 P 
                 0 
                 1 
                 59 
                 F 
                 0 
                 120  
                  2 
                  9 
               
               
                 RA62-MTX 
                   
                 3 
                   
                   
                   
                   
                  0 (100) 
                  0 (100) 
                 12 (0)  
               
               
                 RA63-1110507281 
                 P 
                 0 
                 2 
                 43 
                 F 
                 + 
                 30 
                 10 
                 17 
               
               
                 RA63-MTX 
                   
                 3 
                   
                   
                   
                   
                  0 (100) 
                 6 (40) 
                 15 (12) 
               
               
                 RA64-1110511281 
                 P 
                 0 
                 &lt;1 
                 69 
                 F 
                 + 
                 90 
                  7 
                 21 
               
               
                 RA64-MTX 
                   
                 3 
                   
                   
                   
                   
                  0 (100) 
                 1 (86) 
                  2 (90) 
               
               
                 RA65-1110405273 
                 P 
                 0 
                 5 
                 55 
                 F 
                 + 
                  0 
                  0 
                  2 
               
               
                 RA65-aTNF/MTX 
                   
                 4 
                   
                   
                   
                   
                 10 (0)  
                 6 (0)  
                 16 (0)  
               
               
                 RA66-1110502091 
                 P 
                 0 
                 36 
                 62 
                 F 
                 + 
                 30 
                 13 
                 14 
               
               
                 RA66-aTNF/MTX 
                   
                 30 
                   
                   
                   
                   
                 15 (50) 
                 2 (85) 
                 14 (0)  
               
               
                 RA67-1110507261 
                 P 
                 0 
                 25 
                 43 
                 F 
                 + 
                  0 
                  4 
                  5 
               
               
                 RA67-aTNF/MTX 
                   
                 25 
                   
                   
                   
                   
                 0 (0) 
                  0 (100) 
                  1 (80) 
               
               
                 RA68-1110603141 
                 P 
                 0 
                 12 
                 72 
                 F 
                 + 
                 30 
                 7 
                  7 
               
               
                 RA68-aTNF 
                   
                 12 
                   
                   
                   
                   
                 60 (0)  
                  0 (100) 
                  0 (100) 
               
               
                 RA69-1110510181 
                 P 
                 0 
                 2 
                 33 
                 F 
                 + 
                 50 
                 6 
                  6 
               
               
                 RA69-aTNF/MTX 
                   
                 12 
                   
                   
                   
                   
                  0 (100) 
                  0 (100) 
                  0 (100) 
               
               
                 RA70-06303 
                 P 
                 0 
                 1 
                 53 
                 F 
                 + 
                 30 
                 14 
                 17 
               
               
                 RA70-aTNF/MTX 
                   
                 6 
                   
                   
                   
                   
                 10 (66) 
                  0 (100) 
                  0 (100) 
               
               
                 RA71-06516 
                 P 
                 0 
                 3 
                 79 
                 F 
                 + 
                 30 
                 17 
                 17 
               
               
                 RA71-TNF 
                   
                 6 
                   
                   
                   
                   
                 15 (50) 
                  0 (100) 
                 11 (35) 
               
               
                 RA72-06510 
                 P 
                 0 
                 3 
                 68 
                 F 
                 + 
                 10 
                 25 
                 34 
               
               
                 RA72-TNF 
                   
                 6 
                   
                   
                   
                   
                 10 (0)  
                 2 (92) 
                  0 (100) 
               
               
                 RA73-06309 
                 P 
                 0 
                 1 
                 36 
                 F 
                 0 
                 45 
                 11 
                 27 
               
               
                 RA73-TNF/MTX 
                   
                 6 
                   
                   
                   
                   
                  0 (100) 
                  0 (100) 
                  0 (100) 
               
               
                 RA74-06310 
                 P 
                 0 
                 3 
                 48 
                 F 
                 0 
                 360  
                 14 
                 22 
               
               
                 RA74-TNF 
                   
                 12 
                   
                   
                   
                   
                 15 
                 6 (57) 
                 14 (36) 
               
               
                 RA75-06307 
                 P 
                 0 
                 2 
                 51 
                 F 
                 + 
                 360  
                 16 
                 22 
               
               
                 RA75-MTX 
                   
                 6 
                   
                   
                   
                   
                  0 (100) 
                 2 (87) 
                  3 (86) 
               
               
                 RA76-06311 
                 P 
                 0 
                 3 
                 43 
                 F 
                 + 
                 120  
                 14 
                 36 
               
               
                 RA76-TNF 
                   
                 3 
                   
                   
                   
                   
                  0 (100) 
                  0 (100) 
                  0 (100) 
               
               
                 RA77-06513 
                 P 
                 0 
                 1 
                 53 
                 F 
                 0 
                 120  
                 16 
                 20 
               
               
                 RA77-TNF/MTX 
                   
                 4.5 
                   
                   
                   
                   
                 15 (87) 
                 12 (25)  
                 16 (20) 
               
               
                 RA78-06512 
                 P 
                 0 
                 1 
                 83 
                 F 
                 0 
                 30 
                 15 
                 53 
               
               
                 RA78-MTX 
                   
                 5.5 
                   
                   
                   
                   
                 15 (50) 
                 27 (0)  
                 63 (0)  
               
               
                 RA79-06514 
                 P 
                 0 
                 2 
                 56 
                 F 
                 0 
                 30 
                 21 
                 52 
               
               
                 RA79-TNF/MTX 
                   
                 6 
                   
                   
                   
                   
                 30 (0)  
                 15 (29)  
                 16 (69) 
               
               
                 RA80-1110505241 
                 P 
                 0 
                 4 
                 47 
                 F 
                 + 
                 24 
                  5 
                  9 
               
               
                 RA80-TNF/MTX 
                   
                 3.5 
                   
                   
                   
                   
                 36 (0)  
                 4 (20) 
                  4 (56) 
               
               
                 RA81-06305 
                 P 
                 0 
                 1 
                 18 
                 F 
                 + 
                 30 
                  8 
                 20 
               
               
                 RA81-MTX 
                   
                 6 
                   
                   
                   
                   
                 60 (0)  
                 2 (75) 
                 14 (70) 
               
               
                 RA82-05602 
                 P 
                 0 
                 1 
                 48 
                 F 
                 + 
                 180  
                 29 
                 40 
               
               
                 RA82-MTX 
                   
                 3.5 
                   
                   
                   
                   
                 240 (0)  
                 10 (66)  
                  8 (20) 
               
               
                 RA83-05607 
                 P 
                 0 
                 3 
                 61 
                 M 
                 + 
                 120  
                 25 
                 40 
               
               
                 RA83-MTX 
                   
                 8 
                   
                   
                   
                   
                  0 (100) 
                 3 (88) 
                  3 (92) 
               
               
                 RA84-06302 
                 P 
                 0 
                 3 
                 42 
                 F 
                 + 
                 60 
                 16 
                 39 
               
               
                 RA84-MTX 
                   
                 6 
                   
                   
                   
                   
                 10 (83) 
                 6 (62) 
                 18 (51) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                   
                 ACR 
               
               
                   
                   
                 ESR, 
                 CRP, 
                   
                   
                 improvement 
               
               
                   
                   
                 mm/hr 
                 mg/L 
                 HAQ score 
                 DAS28 
                 (% continuous 
               
               
                   
                 Patient 
                 (% reduction) 
                 (% reduction) 
                 (% reduction) 
                 (% reduction) 
                 score) 
               
               
                   
                   
               
               
                   
                 RA1-1110006211 
                 69 
                 57.5 
                 2.0 
                 6.0 
               
               
                   
                 RA1-aTNF 
                  8 (88) 
                 2.0 (97) 
                 1.3 (35) 
                 3.1 (48) 
                 50 
               
               
                   
                 RA2-1110005181 
                 46 
                 52.2 
                 1.6 
                 6.3 
               
               
                   
                 RA2-aTNF 
                 12 (74) 
                 2.8 (94) 
                 1.0 (37) 
                 2.9 (54) 
                 60 
               
               
                   
                 RA3-1110005291 
                 72 
                 61.1 
                 1.5 
                 6.1 
               
               
                   
                 RA3-aTNF 
                 16 (78) 
                 3.9 (93) 
                 1.0 (33) 
                 4.1 (33) 
                 60 
               
               
                   
                 RA4-1110005031 
                 58 
                 85.3 
                 2.1 
                 6.9 
               
               
                   
                 RA4-aTNF 
                 40 (31) 
                 20.0 (77)  
                 1.3 (38) 
                 6.5 (6)  
                 0 
               
               
                   
                 RA5-1110004141 
                 80 
                 41.5 
                 2.1 
                 6.3 
               
               
                   
                 RA5-aTNF 
                 11 (86) 
                 4.5 (88) 
                 1.4 (33) 
                 4.0 (37) 
                 50 
               
               
                   
                 RA6-1110004131 
                 46 
                 36.0 
                 1.6 
                 5.9 
               
               
                   
                 RA6-aTNF 
                 32 (30) 
                 22.3 (39)  
                 1.6 (0)  
                 5.1 (14) 
                 10 
               
               
                   
                 RA7-1110006221 
                 30 
                 17.3 
                 1.9 
                 6.0 
               
               
                   
                 RA1-aTNF 
                 14 (53) 
                 11.3 (35)  
                 1.3 (32) 
                 4.1 (32) 
                 40 
               
               
                   
                 RA8-06507 
                 30 
                 &lt;3.5 
                 1.6 
                 6.1 
               
               
                   
                 RA8-aTNF/MTX 
                  4 (87) 
                 &lt;3.5 (0)    
                  0.0 (100) 
                 2.4 (61) 
                 70 
               
               
                   
                 RA9-06513 
                 34 
                 &lt;3.5 
                 1.3 
                 6.2 
               
               
                   
                 RA9-aTNF/MTX 
                 14 (59) 
                 &lt;3.5 (0)    
                 1.4 (0)  
                 5.2 (26) 
                 20 
               
               
                   
                 RA10-05602 
                 31 
                 &lt;3.5 
                 2.2 
                 7.1 
               
               
                   
                 RA10-MTX 
                 39 (0)  
                 &lt;3.5 (0)    
                 2.3 (0)  
                 6.8 (4)  
                 0 
               
               
                   
                 RA11-05610 
                 40 
                 39.2 
                 1.4 
                 6.5 
               
               
                   
                 RA11-aTNF 
                 45 (0)  
                 36.4 (7)  
                 0.3 (79) 
                 4.3 (34) 
                 50 
               
               
                   
                 RA12-05609 
                 22 
                 14.3 
                 0.5 
                 6.6 
               
               
                   
                 RA12-aTNF 
                 30 (0)  
                 &lt;3.5 (100) 
                 0.3 (40) 
                 4.3 (35) 
                 50 
               
               
                   
                 RA13-05608 
                 32 
                  5.1 
                 0.8 
                 6.1 
               
               
                   
                 RA13-aTNF/MTX 
                 28 (12) 
                 &lt;3.5 (100) 
                  0.0 (100) 
                 2.7 (56) 
                 90 
               
               
                   
                 RA14-05612 
                 35 
                 13.1 
                 1.0 
                 5.0 
               
               
                   
                 RA14-aTNF/MTX 
                  8 (77) 
                 &lt;3.5 (100) 
                  0.0 (100) 
                 1.7 (66) 
                 100 
               
               
                   
                 RA15-06504 
                 28 
                 &lt;3.5 
                 1.8 
                 6.3 
               
               
                   
                 RA15-aTNF 
                 24 (14) 
                 4.1 (0)  
                 1.3 (28) 
                 3.5 (44) 
                 50 
               
               
                   
                 RA16-06308 
                 56 
                 &lt;3.5 
                 1.8 
                 7.3 
               
               
                   
                 RA16-aTNF/MTX 
                 28 (50) 
                 &lt;3.5 (0)    
                 1.3 (28) 
                 4.8 (44) 
                 40 
               
               
                   
                 RA17-06516 
                 80 
                 22.8 
                 1.8 
                 6.5 
               
               
                   
                 RA17-aTNF 
                 24 (30) 
                 27.5 (0)  
                 0.6 (67) 
                 3.2 (51) 
                 30 
               
               
                   
                 RA18-06309 
                 24 
                 39.4 
                 1.3 
                 6.5 
               
               
                   
                 RA18-aTNF/MTX 
                  8 (67) 
                 8.5 (78) 
                 0.6 (54) 
                 1.9 (71) 
                 70 
               
               
                   
                 RA19-05613 
                 53 
                 31.5 
                 2.3 
                 8.5 
               
               
                   
                 RA19-aTNF 
                 85 (0)  
                 40.0 (0)  
                 1.3 (43) 
                 5.6 (34) 
                 60 
               
               
                   
                 RA20-06304 
                 24 
                 10.0 
                 1.0 
                 6.6 
               
               
                   
                 RA20-aTNF 
                 16 (33) 
                 10.0 (0)  
                 1.0 (0)  
                 3.8 (42) 
                 30 
               
               
                   
                 RA21-06514 
                 34 
                 &lt;3.5 
                 1.4 
                 8.3 
               
               
                   
                 RA21-aTNF/MTX 
                  6 (82) 
                 &lt;3.5 (0)    
                 0.9 (36) 
                 5.4 (35) 
                 20 
               
               
                   
                 RA22-05606 
                 40 
                 23.1 
                 2.4 
                 6.2 
               
               
                   
                 RA22-aTNF/MTX 
                 30 (25) 
                 7.3 (68) 
                 0.8 (67) 
                 4.2 (32) 
                 50 
               
               
                   
                 RA23-06306 
                 90 
                 61.1 
                 2.1 
                 7.1 
               
               
                   
                 RA23-aTNF 
                 62 (33) 
                 53.4 (23)  
                 2.0 (5)  
                 7.2 (0)  
                 0 
               
               
                   
                 RA24-06305 
                 22 
                 29.1 
                 0.3 
                 4.7 
               
               
                   
                 RA24-MTX 
                 20 (10) 
                 31.3 (0)  
                 0.1 (33) 
                 4.1 (13) 
                 20 
               
               
                   
                 RA25-06515 
                 34 
                 &lt;3.5 
                 1.0 
                 8.0 
               
               
                   
                 RA25-aTNF 
                  9 (74) 
                 &lt;3.5 (0)    
                 1.6 (0)  
                 5.8 (27) 
                 0 
               
               
                   
                 RA26-06506 
                 16 
                 &lt;3.5 
                 1.5 
                 5.9 
               
               
                   
                 RA26-aTNF 
                 50 (0)  
                 &lt;3.5 (0)    
                 1.9 (0)  
                 8.3 (0)  
                 0 
               
               
                   
                 RA27-05601 
                 30 
                  6.8 
                 1.1 
                 5.8 
               
               
                   
                 RA27-aTNF 
                 58 (0)  
                 16.9 (0)  
                 1.5 (0)  
                 6.7 (0)  
                 0 
               
               
                   
                 RA28-1110004171 
                 30 
                  7.0 
                 1.8 
                 6.2 
               
               
                   
                 RA28-aTNF 
                 16 (47) 
                 6.9 (1)  
                 0.4 (78) 
                 3.6 (42) 
                 80 
               
               
                   
                 RA29-1110011271 
                 19 
                 16.5 
                 n.d. 
                 4.3 
               
               
                   
                 RA29-aTNF/MTX 
                  9 (53) 
                 3.0 (72) 
                 n.d. 
                 4.1 (13) 
                 0 
               
               
                   
                 RA30-1110010101 
                 52 
                 42.6 
                 n.d. 
                 5.3 
               
               
                   
                 RA30-aTNF/MTX 
                 17 (63) 
                 10.1 (76)  
                 n.d. 
                 2.6 (51) 
                 50 
               
               
                   
                 RA31-1110004121 
                 33 
                  7.8 
                 1.3 
                 5.2 
               
               
                   
                 RA31-aTNF 
                 18 (45) 
                 5.9 (24) 
                 0.9 (31) 
                 3.4 (35) 
                 40 
               
               
                   
                 RA32-1110008092 
                 29 
                 18.4 
                 n.d. 
                 6.8 
               
               
                   
                 RA32-aTNF 
                 28 (3)  
                 21.0 (0)  
                 n.d. 
                 3.4 (50) 
                 50 
               
               
                   
                 RA33-1110005121 
                 28 
                 22.4 
                 1.8 
                 6.3 
               
               
                   
                 RA33-aTNF 
                 26 (7)  
                 14.0 (36)  
                 1.9 (0)  
                 4.1 (35) 
                 20 
               
               
                   
                 RA34-1110111281 
                 18 
                  9.0 
                  1.43 
                  4.29 
               
               
                   
                 RA34-MTX 
                 13 (28) 
                 12.0 (0)  
                 0.74 (49)  
                 5.10 (0)  
                 0 
               
               
                   
                 RA35-1110112121 
                 17 
                 66.0 
                  2.67 
                 6.3 
               
               
                   
                 RA35-MTX 
                 12 (29) 
                 &lt;3.5 (100) 
                 0.67 (76)  
                 3.5 (45) 
                 60 
               
               
                   
                 RA36-1110201231 
                 38 
                 45.0 
                  2.33 
                 6.3 
               
               
                   
                 RA36-MTX 
                 17 (55) 
                 5.0 (89) 
                 0.33 (86)  
                 2.1 (67) 
                 80 
               
               
                   
                 RA37-1110211051 
                 27 
                 11.0 
                  2.44 
                 5.5 
               
               
                   
                 RA37-MTX 
                  8 (70) 
                 5.0 (55) 
                 1.44 (41)  
                 2.9 (47) 
                 40 
               
               
                   
                 RA38-1110309012 
                 20 
                  8.1 
                  1.11 
                 5.4 
               
               
                   
                 RA38-MTX 
                 10 (50) 
                 1.2 (85) 
                 0.44 (60)  
                 2.5 (54) 
                 70 
               
               
                   
                 RA39-1110309122 
                 101  
                 33.0 
                  2.67 
                 6.5 
               
               
                   
                 RA39-MTX 
                 81 (20) 
                 44.5 (0)  
                 2.10 (21)  
                 5.6 (14) 
                 20 
               
               
                   
                 RA40-1110310302 
                 72 
                 77.6 
                 2.1 
                 6.8 
               
               
                   
                 RA40-MTX 
                 18 (75) 
                 6.9 (91) 
                 1.1 (49) 
                 3.4 (50) 
                 50 
               
               
                   
                 RA41-1110411251 
                 17 
                 &lt;3.5 
                 2.4 
                 5.4 
               
               
                   
                 RA41-MTX 
                 12 (29) 
                 &lt;3.5 (0)    
                   0 (100) 
                 3.1 (43) 
                 80 
               
               
                   
                 RA42-1110409071 
                 37 
                 22.0 
                 2.1 
                 5.7 
               
               
                   
                 RA42-MTX 
                  5 (87) 
                 6.6 (70) 
                 0.4 (81) 
                 1.1 (81) 
                 80 
               
               
                   
                 RA43-1110409141 
                 27 
                 32.0 
                 2.3 
                 5.9 
               
               
                   
                 RA43-MTX 
                  3 (89) 
                 4.6 (86) 
                 2.0 (13) 
                 1.7 (71) 
                 70 
               
               
                   
                 RA44-1110409223 
                 55 
                 62.6 
                  1.33 
                  3.13 
               
               
                   
                 RA44-MTX 
                 12 (78) 
                 3.80 (94)  
                 1.40 (0)  
                 4.93 (0)  
                 70 
               
               
                   
                 RA45-1110411291 
                 34 
                 18.0 
                 1.4 
                 4.9 
               
               
                   
                 RA45-MTX 
                 20 (41) 
                 12.6 (30)  
                   0 (100) 
                 2.2 (65) 
                 60 
               
               
                   
                 RA46-1110602212 
                 74 
                 17.8 
                 1.7 
                 5.8 
               
               
                   
                 RA46-aTNF/MTX 
                 20 (63) 
                 2.7 (85) 
                 1.1 (35) 
                 4.4 (24) 
                 30 
               
               
                   
                 RA47-1110503081 
                 74 
                 &lt;3.5 
                 2.0 
                 6.5 
               
               
                   
                 RA47-TNF 
                 20 (0)  
                 &lt;3.5 (0)    
                 2.8 (0)  
                 6.7 (0)  
                 0 
               
               
                   
                 RA48-1110703082 
                 28 
                 106.0  
                 1.1 
                 6.2 
               
               
                   
                 RA48-TNF 
                 120 (12)  
                 83.6 (21)  
                 1.0 (9)  
                 4.1 (34) 
                 0 
               
               
                   
                 RA49-1110309122 
                 40 
                 33.0 
                 0.9 
                 6.6 
               
               
                   
                 RA49-MTX 
                 40 (0)  
                 34.5 (0)  
                 0.7 (22) 
                 5.7 (14) 
                 10 
               
               
                   
                 RA50-1100308202 
                 28 
                  9.8 
                 1.4 
                 4.6 
               
               
                   
                 RA50-MTX 
                 21 (25) 
                 9.9 (0)  
                 1.7 (0)  
                 4.0 (13) 
                 0 
               
               
                   
                 RA51-1110309111 
                 10 
                  4.0 
                 2.2 
                 6.1 
               
               
                   
                 RA51-MTX 
                  5 (50) 
                 1.3 (77) 
                 2.1 (5)  
                 5.1 (16) 
                 0 
               
               
                   
                 RA52-1110401081 
                 30 
                  6.5 
                 1.1 
                 4.4 
               
               
                   
                 RA52-MTX 
                 25 (17) 
                 4.8 (26) 
                 0.1 (91) 
                 2.3 (48) 
                 90 
               
               
                   
                 RA53-1110406011 
                 10 
                 23.0 
                 1.78 
                 6.4 
               
               
                   
                 RA53-MTX 
                  0 (100) 
                 3.1 (87) 
                 0.3 (83) 
                 2.4 (62) 
                 80 
               
               
                   
                 RA54-1110406112 
                 10 
                  9.0 
                 0.7 
                 5.2 
               
               
                   
                 RA54-MTX 
                 20 (0)  
                 16.7 (0)  
                 1.9 (0)  
                 3.3 (37) 
                 40 
               
               
                   
                 RA55-1110406111 
                 25 
                 24.8 
                 1.9 
                 5.4 
               
               
                   
                 RA55-MTX 
                 12 (52) 
                 6.7 (73) 
                 0.3 (84) 
                 2.4 (56) 
                 80 
               
               
                   
                 RA56-1110407131 
                 55 
                 37.8 
                 1.67 
                 8.8 
               
               
                   
                 RA56-MTX 
                 14 (75) 
                 1.0 (97) 
                 1.10 (34)  
                 3.7 (58) 
                 30 
               
               
                   
                 RA57-1110407281 
                 21 
                  3.9 
                 1.6 
                 5.5 
               
               
                   
                 RA57-MTX 
                 10 (52) 
                 &lt;3.5 (100) 
                 0.2 (87) 
                 2.5 (55) 
                 70 
               
               
                   
                 RA58-1110409201 
                 20 
                 &lt;3.5 
                 2.2 
                 4.3 
               
               
                   
                 RA58-MTX 
                 14 (30) 
                 &lt;3.5 (0)    
                 0.4 (82) 
                 2.0 (53) 
                 70 
               
               
                   
                 RA59-1110410271 
                 12 
                 &lt;3.5 
                 0.8 
                 2.6 
               
               
                   
                 RA59-MTX 
                 25 (0)  
                 7.9 (0)  
                 0.8 (0)  
                 2.7 (0)  
                 30 
               
               
                   
                 RA60-1110503231 
                 14 
                  5.6 
                 2 
                 5.9 
               
               
                   
                 RA60-MTX 
                  8 (43) 
                 4.9 (12) 
                 0.9 (55) 
                 3.1 (47) 
                 40 
               
               
                   
                 RA61-1110504061 
                 16 
                 &lt;3.5 
                 2.5 
                 7.0 
               
               
                   
                 RA61-MTX 
                  4 (75) 
                 &lt;3.5 (0)    
                 0.4 (84) 
                 1.0 (86) 
                 70 
               
               
                   
                 RA62-1110505301 
                 10 
                 &lt;3.5 
                 2.1 
                 4.7 
               
               
                   
                 RA62-MTX 
                  6 (40) 
                 &lt;3.5 (0)    
                 1.1 (48) 
                 3.2 (26) 
                 40 
               
               
                   
                 RA63-1110507281 
                 68 
                 42.0 
                 1.8 
                 6.0 
               
               
                   
                 RA63-MTX 
                 20 (71) 
                 33.0 (21)  
                 1.1 (39) 
                 4.0 (33) 
                 30 
               
               
                   
                 RA64-1110511281 
                 25 
                 14.5 
                 1.2 
                 5.8 
               
               
                   
                 RA64-MTX 
                 10 (60) 
                 27.0 (0)  
                 0.9 (25) 
                 3.0 (48) 
                 20 
               
               
                   
                 RA65-1110405273 
                  6 
                 &lt;3.5 
                 1.2 
                 3.0 
               
               
                   
                 RA65-aTNF/MTX 
                 12 (0)  
                 &lt;3.5 (0)    
                 0.8 (33) 
                 4.7 (0)  
                 0 
               
               
                   
                 RA66-1110502091 
                 10 
                 &lt;3.5 
                 1.9 
                 4.2 
               
               
                   
                 RA66-aTNF/MTX 
                 12 (0)  
                 4.2 (0)  
                   0 (100) 
                 4.1 (2)  
                 40 
               
               
                   
                 RA67-1110507261 
                 32 
                 11.4 
                 1.7 
                 4.4 
               
               
                   
                 RA67-aTNF/MTX 
                 16 (50) 
                 7.7 (32) 
                 1.1 (35) 
                 2.8 (36) 
                 30 
               
               
                   
                 RA68-1110603141 
                 72 
                  4.8 
                 1.3 
                 4.7 
               
               
                   
                 RA68-aTNF 
                  4 (94) 
                 &lt;3.5 (100) 
                  0.0 (100) 
                 2.4 (49) 
                 30 
               
               
                   
                 RA69-1110510181 
                 12 
                  9.0 
                 3.0 
                 4.7 
               
               
                   
                 RA69-aTNF/MTX 
                 26 (0)  
                 &lt;3.5 (100) 
                 1.1 (63) 
                 2.4 (49) 
                 80 
               
               
                   
                 RA70-06303 
                 26 
                 31.9 
                 1.3 
                 5.8 
               
               
                   
                 RA70-aTNF/MTX 
                  6 (77) 
                   0 (100) 
                 0.1 (92) 
                 1.6 (73) 
                 70 
               
               
                   
                 RA71-06516 
                 80 
                 22.8 
                 1.8 
                 6.5 
               
               
                   
                 RA71-TNF 
                 24 (70) 
                 7.5 (67) 
                 0.6 (67) 
                 3.2 (49) 
                 30 
               
               
                   
                 RA72-06510 
                 80 
                 41.6 
                 2.1 
                 8.2 
               
               
                   
                 RA72-TNF 
                 58 (27) 
                 21.4 (49)  
                 1.5 (29) 
                 2.6 (68) 
                 70 
               
               
                   
                 RA73-06309 
                 24 
                 39.4 
                 1.3 
                 6.5 
               
               
                   
                 RA73-TNF/MTX 
                  8 (75) 
                 8.5 (78) 
                 0.6 (54) 
                 1.9 (71) 
                 70 
               
               
                   
                 RA74-06310 
                 30 
                 21.9 
                 3.0 
                 8.1 
               
               
                   
                 RA74-TNF 
                 13 (57) 
                 14.3 (35)  
                 2.3 (23) 
                 2.9 (64) 
                 50 
               
               
                   
                 RA75-06307 
                 64 
                 83.4 
                 2.6 
                 7.0 
               
               
                   
                 RA75-MTX 
                 22 (66) 
                 11.5 (86)  
                 0.8 (69) 
                 2.2 (69) 
                 70 
               
               
                   
                 RA76-06311 
                 32 
                 53.1 
                 0.8 
                 7.0 
               
               
                   
                 RA76-TNF 
                  8 (75) 
                 4.9 (91) 
                 0.1 (87) 
                 1.7 (75) 
                 80 
               
               
                   
                 RA77-06513 
                 34 
                 &lt;3.5 
                 1.3 
                 6.2 
               
               
                   
                 RA77-TNF/MTX 
                 14 (59) 
                 &lt;3.5 (0)    
                 1.4 (0)  
                 5.3 (15) 
                 20 
               
               
                   
                 RA78-06512 
                 33 
                  7.4 
                 2.4 
                 6.7 
               
               
                   
                 RA78-MTX 
                  8 (76) 
                 4.9 (34) 
                 3.0 (0)  
                 8.3 (0)  
                 0 
               
               
                   
                 RA79-06514 
                 34 
                 &lt;3.5 
                 1.3 
                 8.3 
               
               
                   
                 RA79-TNF/MTX 
                  6 (82) 
                 &lt;3.5 (0)    
                 0.9 (31) 
                 5.4 (35) 
                 20 
               
               
                   
                 RA80-1110505241 
                 24 
                 10.2 
                 1.3 
                 4.4 
               
               
                   
                 RA80-TNF/MTX 
                 36 (0)  
                 &lt;3.5 (100) 
                 1.1 (15) 
                 4.1 (7)  
                 20 
               
               
                   
                 RA81-06305 
                 22 
                 29.1 
                 0.3 
                 6.0 
               
               
                   
                 RA81-MTX 
                 20 (9)  
                 31.3 (0)  
                 0.1 (33) 
                 4.1 (32) 
                 20 
               
               
                   
                 RA82-05602 
                 31 
                 &lt;3.5 
                 2.1 
                 4.0 
               
               
                   
                 RA82-MTX 
                 39 (0)  
                 &lt;3.5 (0)    
                 2.3 (0)  
                 6.5 (0)  
                 0 
               
               
                   
                 RA83-05607 
                 29 
                  4.6 
                 2.5 
                 7.8 
               
               
                   
                 RA83-MTX 
                 12 (59) 
                   0 (100) 
                 1.3 (52) 
                 3.1 (60) 
                 60 
               
               
                   
                 RA84-06302 
                 30 
                  9.6 
                 2.5 
                 7.4 
               
               
                   
                 RA84-MTX 
                 24 ( )  
                 &lt;3.5 (100) 
                 0.8 (68) 
                 5.3 (28) 
                 60 
               
               
                   
                   
               
               
                   
                 A = Affymetrix; R = real-time RT-PCR (validation of gene expression); P = real-time RT-PCR (validation of predictive gene); RF = rheumatoid factor;; ESR = erythrocyte sedimentation rate; CRP = C-reactive protein concentration, HAQ = Health Assessment Questionnaire; DAS28 = disease activity score (28 joints); 
               
               
                   
                 + = positive; − = negative; n.d. = not determined; aTNF = anti-TNF monoclonal antibody therapy; MTX = methotrexate therapy 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 Correlations among clinical parameters (Pearson correlation test; 
               
               
                 pre- and post-anti-TNFα treatment) 
               
            
           
           
               
               
               
            
               
                   
                 r-value 
                 p-value 
               
               
                   
               
            
           
           
               
               
               
            
               
                 Morning stiffness/Swollen joint count 28 
                 0.718 
                 0.004 
               
               
                 Morning stiffness/Swollen joint count 68 
                 0.664 
                 0.010 
               
               
                 Swollen joint count 28/Swollen joint count 68 
                 0.990 
                 0.000 
               
               
                 Painful joint count 28/Painful joint count 68 
                 0.794 
                 0.001 
               
               
                 ESR/CRP 
                 0.854 
                 0.000 
               
               
                 ESR/VAS (physician) 
                 0.764 
                 0.001 
               
               
                 ESR/DAS 28 
                 0.813 
                 0.000 
               
               
                 CRP/Morning stiffness 
                 0.733 
                 0.003 
               
               
                 CRP/Swollen joint count 28 
                 0.762 
                 0.002 
               
               
                 CRP/Swollen joint count 68 
                 0.728 
                 0.003 
               
               
                 CRP/DAS 28 
                 0.786 
                 0.001 
               
               
                 DAS 28/Swollen joint count 28 
                 0.891 
                 0.000 
               
               
                 DAS 28/Swollen joint count 68 
                 0.878 
                 0.000 
               
               
                 DAS 28/Painful joint count 28 
                 0.660 
                 0.010 
               
               
                 VAS (physician)/Swollen joint count 68 
                 0.672 
                 0.008 
               
               
                 VAS (physician)/Painful joint count 28 
                 0.697 
                 0.006 
               
               
                 VAS (physician)/DAS 28 
                 0.790 
                 0.001 
               
               
                   
               
               
                 Different clinical parameters showed correlations in RA patients pre- and post anti-TNFα treatment (n = 14 in all cases). 
               
               
                 ESR = erythrocyte sedimentation rate; 
               
               
                 CRP = C-reactive protein; 
               
               
                 DAS 28 = disease activity score (28 joints); and 
               
               
                 VAS (physician) = visual analogue score (physican&#39;s global assessment) 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 3 
               
               
                   
               
               
                 Genes differentially regulated in peripheral blood monocytes of both RA 
               
               
                 patients versus normal donors and RA patients pre-versus post-anti-TNFα 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                 Increased 
                 Decreased 
                 Fold 
                   
               
               
                 Affymetrix 
                   
                 (%) 
                 (%) 
                 change 
                 SLR 
               
            
           
           
               
               
               
            
               
                 ID 
                 Gene name 
                 RA vs. ND 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 36711_at 
                 v-maf musculoaponeurotic fibrosarcoma 
                 71.43 
                 14.29 
                 3.44 
                 1.78 
               
               
                   
                 oncogene homolog F 
               
               
                 38037_at 
                 Diphtheria toxin receptor (DTR) 
                 71.43 
                 10.20 
                 2.87 
                 1.52 
               
               
                 201386_s_at 
                 DEAH (Asp-Glu-Ala-His) box polypeptide 15 
                 2.04 
                 73.47 
                 −1.66 
                 −0.73 
               
               
                 201890_at 
                 Ribonucleotide reductase M2 polypeptide 
                 81.63 
                 8.16 
                 4.39 
                 2.13 
               
               
                 202219_at 
                 Solute carrier family 6, member 8 
                 71.43 
                 8.16 
                 8.44 
                 3.08 
               
               
                 202464_s_at 
                 6-phosphofructo-2-kinase/fructose-2,6- 
                 81.63 
                 — 
                 2.74 
                 1.46 
               
               
                   
                 biphosphatase 3 
               
               
                 203115_at 
                 Ferrochelatase (protoporphyria) 
                 83.67 
                 8.16 
                 3.87 
                 1.95 
               
               
                 203574_at 
                 Nuclear factor, interleukin 3 regulated 
                 77.55 
                 — 
                 2.16 
                 1.11 
               
               
                 203887_s_at 
                 Thrombomodulin 
                 71.43 
                 16.33 
                 2.49 
                 1.32 
               
               
                 203932_at 
                 Major histocompatibility complex, class II, 
                 2.04 
                 75.51 
                 −1.82 
                 −0.87 
               
               
                   
                 DM beta 
               
               
                 204131_s_at 
                 Forkhead box O3A 
                 77.55 
                 4.08 
                 2.21 
                 1.14 
               
               
                 204419_x_at 
                 Hemoglobin, gamma A, gamma G 
                 75.51 
                 6.12 
                 2.88 
                 1.52 
               
               
                 204467_s_at 
                 Synuclein, alpha (non A4 component of 
                 71.43 
                 4.08 
                 3.60 
                 1.85 
               
               
                   
                 amyloid precursor) 
               
               
                 204848_x_at 
                 Hemoglobin, gamma A 
                 75.51 
                 6.12 
                 3.83 
                 1.94 
               
               
                 205239_at 
                 Amphiregulin (schwannoma-derived growth 
                 81.63 
                 4.08 
                 6.13 
                 2.62 
               
               
                   
                 factor) 
               
               
                 205571_at 
                 Lipoyltransferase 1 
                 — 
                 79.59 
                 −1.90 
                 −0.93 
               
               
                 205592_at 
                 Solute carrier family 4, anion exchanger, 
                 77.55 
                 10.20 
                 4.83 
                 2.27 
               
               
                   
                 member 1 
               
               
                 205863_at 
                 S100 calcium binding protein A12 
                 71.43 
                 4.08 
                 1.69 
                 0.76 
               
               
                   
                 (calgranulin C) 
               
               
                 205900_at 
                 Keratin 1 (epidermolytic hyperkeratosis) 
                 75.51 
                 6.12 
                 4.03 
                 2.01 
               
               
                 205950_s_at 
                 Carbonic anhydrase I 
                 81.63 
                 4.08 
                 5.88 
                 2.56 
               
               
                 205987_at 
                 CD1C antigen, c polypeptide 
                 — 
                 87.76 
                 −2.93 
                 −1.55 
               
               
                 206025_s_at 
                 Tumor necrosis factor, alpha-induced protein 6 
                 71.43 
                 — 
                 3.85 
                 1.94 
               
               
                 206111_at 
                 Ribonuclease, RNase A family, 2 
                 73.47 
                 — 
                 1.95 
                 0.97 
               
               
                 206834_at 
                 Hemoglobin, delta 
                 83.67 
                 10.20 
                 4.08 
                 2.03 
               
               
                 207332_s_at 
                 Transferrin receptor (p90, CD71) 
                 81.63 
                 2.04 
                 2.35 
                 1.23 
               
               
                 208632_at 
                 Ring finger protein 10 
                 71.43 
                 6.12 
                 2.06 
                 1.04 
               
               
                 209007_s_at 
                 Chromosome 1 open reading frame 63 
                 4.08 
                 73.47 
                 −2.14 
                 −1.10 
               
               
                 209458_x_at 
                 Hemoglobin, alpha 1, alpha 2 
                 85.71 
                 2.04 
                 3.00 
                 1.59 
               
               
                 209795_at 
                 CD69 antigen (p60, early T-cell activation 
                 71.43 
                 12.24 
                 2.95 
                 1.56 
               
               
                   
                 antigen 
               
               
                 210027_s_at 
                 APEX nuclease (multifunctional DNA repair 
                 — 
                 75.51 
                 −1.93 
                 −0.94 
               
               
                   
                 enzyme) 1 
               
               
                 210254_at 
                 Membrane-spanning 4-domains, subfamily A, 
                 73.47 
                 16.33 
                 3.41 
                 1.77 
               
               
                   
                 member 3 
               
               
                 210338_s_at 
                 Heat shock 70 kDa protein 8 
                 6.12 
                 71.43 
                 −2.09 
                 −1.06 
               
               
                 211038_s_at 
                 Hypothetical protein MGC12760 
                 — 
                 71.43 
                 −2.07 
                 −1.05 
               
               
                 211458_s_at 
                 GABA(A) receptor-associated protein like 1, 
                 71.43 
                 — 
                 1.95 
                 0.96 
               
               
                   
                 like 3 
               
               
                 211560_s_at 
                 Aminolevulinate, delta-, synthase 2 
                 87.76 
                 4.08 
                 24.35 
                 4.61 
               
               
                 211991_s_at 
                 Major histocompatibility complex, class II, DP 
                 4.08 
                 79.59 
                 −3.01 
                 −1.59 
               
               
                   
                 alpha 1 
               
               
                 212199_at 
                 Morf4 family associated protein 1-like 1 
                 2.04 
                 75.51 
                 −1.94 
                 −0.96 
               
               
                 212224_at 
                 Aldehyde dehydrogenase 1 family, member A1 
                 4.08 
                 75.51 
                 −2.56 
                 −1.36 
               
               
                 212232_at 
                 Formin binding protein 4 
                 — 
                 77.55 
                 −1.83 
                 −0.87 
               
               
                 212534_at 
                 Zinc finger protein 24 (KOX 17) 
                 6.12 
                 71.43 
                 −1.49 
                 −0.58 
               
               
                 213142_x_at 
                 Hypothetical protein LOC54103 
                 4.08 
                 73.47 
                 −1.77 
                 −0.82 
               
               
                 214433_s_at 
                 Selenium binding protein 1 
                 71.43 
                 10.20 
                 4.59 
                 2.20 
               
               
                 215933_s_at 
                 Hematopoietically expressed homeobox 
                 — 
                 75.51 
                 −1.83 
                 −0.87 
               
               
                 217478_s_at 
                 Major histocompatibility complex, class II, 
                 4.08 
                 73.47 
                 −2.02 
                 −1.01 
               
               
                   
                 DM alpha 
               
               
                 217736_s_at 
                 Eukaryotic translation initiation factor 2-alpha 
                 75.51 
                 — 
                 1.97 
                 0.98 
               
               
                   
                 kinase 1 
               
               
                 219069_at 
                 Ankyrin repeat domain 49 
                 — 
                 73.47 
                 −1.59 
                 −0.67 
               
               
                 219093_at 
                 Hypothetical protein FLJ20701 
                 — 
                 85.71 
                 −3.32 
                 −1.73 
               
               
                 219228_at 
                 Zinc finger protein 331 
                 77.55 
                 8.16 
                 3.94 
                 1.98 
               
               
                 219607_s_at 
                 Membrane-spanning 4-domains, subfamily A, 
                 91.84 
                 — 
                 2.96 
                 1.57 
               
               
                   
                 member 4 
               
               
                 221748_s_at 
                 Tensin 1 
                 81.63 
                 4.08 
                 4.29 
                 2.10 
               
               
                 221766_s_at 
                 Family with sequence similarity 46, member A 
                 — 
                 71.43 
                 −1.71 
                 −0.77 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                   
                   
                 Increased 
                 Decreased 
                 Fold 
                   
                 Increased 
                 Decreased 
                 Fold 
                   
               
               
                   
                 Affymetrix 
                 (%) 
                 (%) 
                 change 
                 SLR 
                 (%) 
                 (%) 
                 change 
                 SLR 
               
            
           
           
               
               
               
               
            
               
                   
                 ID 
                 RA-aTNF vs. RA (all) 
                 RA-aTNF vs. RA (responder) 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                   
                 36711_at 
                 28.57 
                 61.22 
                 −2.78 
                 −1.48 
                 12.00 
                 80.00 
                 −5.88 
                 −2.56 
               
               
                   
                 38037_at 
                 12.24 
                 73.47 
                 −2.59 
                 −1.37 
                 — 
                 84.00 
                 −3.70 
                 −1.89 
               
               
                   
                 201386_s_at 
                 44.90 
                 14.29 
                 1.43 
                 0.51 
                 60.00 
                 — 
                 1.81 
                 0.85 
               
               
                   
                 201890_at 
                 2.04 
                 69.39 
                 −3.86 
                 −1.95 
                 4.00 
                 64.00 
                 −3.88 
                 −1.96 
               
               
                   
                 202219_at 
                 12.24 
                 59.18 
                 −5.17 
                 −2.37 
                 4.00 
                 72.00 
                 −6.96 
                 −2.80 
               
               
                   
                 202464_s_at 
                 12.24 
                 69.39 
                 −2.18 
                 −1.12 
                 — 
                 84.00 
                 −3.01 
                 −1.59 
               
               
                   
                 203115_at 
                 20.41 
                 63.27 
                 −2.18 
                 −1.12 
                 16.00 
                 72.00 
                 −2.25 
                 −1.17 
               
               
                   
                 203574_at 
                 10.20 
                 53.06 
                 −1.54 
                 −0.62 
                 — 
                 76.00 
                 −2.06 
                 −1.04 
               
               
                   
                 203887_s_at 
                 12.24 
                 65.31 
                 −2.34 
                 −1.23 
                 — 
                 76.00 
                 −3.14 
                 −1.65 
               
               
                   
                 203932_at 
                 63.27 
                 4.08 
                 1.64 
                 0.71 
                 84.00 
                 — 
                 1.68 
                 0.75 
               
               
                   
                 204131_s_at 
                 18.37 
                 55.10 
                 −1.42 
                 −0.50 
                 4.00 
                 64.00 
                 −1.41 
                 −0.50 
               
               
                   
                 204419_x_at 
                 14.29 
                 75.51 
                 −3.18 
                 −1.67 
                 8.00 
                 92.00 
                 −4.16 
                 −2.04 
               
               
                   
                 204467_s_at 
                 24.49 
                 65.31 
                 −2.26 
                 −1.18 
                 16.00 
                 80.00 
                 −2.93 
                 −1.55 
               
               
                   
                 204848_x_at 
                 16.33 
                 65.31 
                 −3.22 
                 −1.69 
                 4.00 
                 80.00 
                 −4.63 
                 −2.21 
               
               
                   
                 205239_at 
                 20.41 
                 71.43 
                 −3.36 
                 −1.75 
                 — 
                 96.00 
                 −5.91 
                 −2.56 
               
               
                   
                 205571_at 
                 51.02 
                 12.24 
                 1.35 
                 0.44 
                 72.00 
                 — 
                 1.61 
                 0.69 
               
               
                   
                 205592_at 
                 16.33 
                 65.31 
                 −3.81 
                 −1.93 
                 8.00 
                 76.00 
                 −5.63 
                 −2.49 
               
               
                   
                 205863_at 
                 14.29 
                 55.10 
                 −1.49 
                 −0.58 
                 8.00 
                 56.00 
                 −1.56 
                 −0.64 
               
               
                   
                 205900_at 
                 20.41 
                 67.35 
                 −2.31 
                 −1.21 
                 16.00 
                 84.00 
                 −3.18 
                 −1.67 
               
               
                   
                 205950_s_at 
                 22.45 
                 67.35 
                 −2.87 
                 −1.52 
                 16.00 
                 84.00 
                 −4.14 
                 −2.05 
               
               
                   
                 205987_at 
                 63.27 
                 2.04 
                 1.72 
                 0.79 
                 68.00 
                 — 
                 1.72 
                 0.78 
               
               
                   
                 206025_s_at 
                 12.24 
                 59.18 
                 −1.97 
                 −0.98 
                 4.00 
                 72.00 
                 −2.74 
                 −1.46 
               
               
                   
                 206111_at 
                 8.16 
                 67.35 
                 −1.59 
                 −0.67 
                 — 
                 72.00 
                 −1.68 
                 −0.75 
               
               
                   
                 206834_at 
                 20.41 
                 65.31 
                 −3.13 
                 −1.64 
                 16.00 
                 80.00 
                 −4.59 
                 −2.20 
               
               
                   
                 207332_s_at 
                 2.04 
                 79.59 
                 −2.45 
                 −1.29 
                 — 
                 84.00 
                 −2.57 
                 −1.36 
               
               
                   
                 208632_at 
                 12.24 
                 59.18 
                 −1.71 
                 −0.78 
                 4.00 
                 68.00 
                 −1.69 
                 −0.76 
               
               
                   
                 209007_s_at 
                 57.14 
                 14.29 
                 1.54 
                 0.62 
                 76.00 
                 4.00 
                 1.87 
                 0.90 
               
               
                   
                 209458_x_at 
                 8.16 
                 63.27 
                 −2.09 
                 −1.06 
                 4.00 
                 76.00 
                 −2.60 
                 −1.38 
               
               
                   
                 209795_at 
                 14.29 
                 75.51 
                 −3.18 
                 −1.67 
                 16.00 
                 76.00 
                 −3.77 
                 −1.92 
               
               
                   
                 210027_s_at 
                 67.35 
                 10.20 
                 1.64 
                 0.72 
                 84.00 
                 — 
                 2.02 
                 1.02 
               
               
                   
                 210254_at 
                 14.29 
                 79.59 
                 −4.56 
                 −2.19 
                 20.00 
                 76.00 
                 −3.69 
                 −1.88 
               
               
                   
                 210338_s_at 
                 55.10 
                 18.37 
                 1.57 
                 0.66 
                 68.00 
                 4.00 
                 2.04 
                 1.03 
               
               
                   
                 211038_s_at 
                 42.86 
                 16.33 
                 1.29 
                 0.37 
                 56.00 
                 4.00 
                 1.46 
                 0.55 
               
               
                   
                 211458_s_at 
                 16.33 
                 65.31 
                 −1.92 
                 −0.94 
                 — 
                 84.00 
                 −2.75 
                 −1.46 
               
               
                   
                 211560_s_at 
                 16.33 
                 75.51 
                 −10.81 
                 −3.43 
                 8.00 
                 80.00 
                 −20.53 
                 −4.36 
               
               
                   
                 211991_s_at 
                 75.51 
                 8.16 
                 2.37 
                 1.24 
                 80.00 
                 4.00 
                 2.54 
                 1.34 
               
               
                   
                 212199_at 
                 59.18 
                 10.20 
                 1.56 
                 0.64 
                 80.00 
                 — 
                 2.11 
                 1.08 
               
               
                   
                 212224_at 
                 71.43 
                 12.24 
                 2.28 
                 1.19 
                 92.00 
                 — 
                 2.74 
                 1.45 
               
               
                   
                 212232_at 
                 48.98 
                 14.29 
                 1.27 
                 0.35 
                 72.00 
                 — 
                 1.57 
                 0.65 
               
               
                   
                 212534_at 
                 53.06 
                 4.08 
                 1.35 
                 0.43 
                 76.00 
                 — 
                 1.45 
                 0.53 
               
               
                   
                 213142_x_at 
                 51.02 
                 12.24 
                 1.25 
                 0.32 
                 72.00 
                 — 
                 1.51 
                 0.60 
               
               
                   
                 214433_s_at 
                 18.37 
                 65.31 
                 −3.08 
                 −1.62 
                 12.00 
                 68.00 
                 −3.55 
                 −1.83 
               
               
                   
                 215933_s_at 
                 55.10 
                 6.12 
                 1.51 
                 0.59 
                 76.00 
                 0.00 
                 1.85 
                 0.88 
               
               
                   
                 217478_s_at 
                 61.22 
                 12.24 
                 1.68 
                 0.75 
                 64.00 
                 8.00 
                 1.85 
                 0.88 
               
               
                   
                 217736_s_at 
                 14.29 
                 51.02 
                 −1.46 
                 −0.54 
                 8.00 
                 60.00 
                 −1.41 
                 −0.50 
               
               
                   
                 219069_at 
                 57.14 
                 12.24 
                 1.30 
                 0.38 
                 84.00 
                 — 
                 1.58 
                 0.66 
               
               
                   
                 219093_at 
                 71.43 
                 8.16 
                 2.43 
                 1.28 
                 84.00 
                 — 
                 2.59 
                 1.37 
               
               
                   
                 219228_at 
                 10.20 
                 71.43 
                 −3.26 
                 −1.70 
                 12.00 
                 80.00 
                 −4.62 
                 −2.21 
               
               
                   
                 219607_s_at 
                 6.12 
                 73.47 
                 −1.95 
                 −0.96 
                 — 
                 80.00 
                 −2.06 
                 −1.04 
               
               
                   
                 221748_s_at 
                 24.49 
                 65.31 
                 −2.12 
                 −1.08 
                 16.00 
                 80.00 
                 −2.42 
                 −1.28 
               
               
                   
                 221766_s_at 
                 53.06 
                 10.20 
                 1.30 
                 0.38 
                 80.00 
                 — 
                 1.66 
                 0.73 
               
               
                   
                   
               
               
                   
                 The table presents the percentage of pairwise comparisons between the respective groups showing an increase or decrease for the fold-change/Signal Log Ratio (SLR; 51 candidate genes were selected); n = 7 each for the comparisons RA vs. ND and RA-αTNF vs. RA (all); n = 5 for the comparison RA-αTNF vs. RA (responder). 
               
               
                   
                 The pairwise comparison RA-αTNF vs. RA (all) is shown in the central 4 columns to assess the effect of treatment on differential gene expression in all TNFα-treated RA patients. 
               
               
                   
                 RA = rheumatoid arthritis (pre-anti-TNFα treatment); ND = normal donor; RA-αTNF = rheumatoid arthritis (post-anti-TNFα treatment) 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 Genes differentially regulated in peripheral blood monocytes of both RA patients versus normal donors and RA 
               
               
                 patients pre-versus post-anti-TNFα therapy (PAM analysis) 
               
            
           
           
               
               
               
            
               
                 Affymetrix ID 
                 Gene title 
                 RA score 
               
               
                   
               
            
           
           
               
               
               
            
               
                 221622_s_at 
                 Uncharacterized hypothalamus protein HT007 
                 0.7405 
               
               
                 218845_at 
                 Dual specificity phosphatase 22 
                 0.6694 
               
               
                 200786_at 
                 Proteasome (prosome, macropain) subunit, beta type, 7 
                 0.5297 
               
               
                 219607_s_at 
                 
                   Membrane-spanning 4-domains, subfamily A, member 4 
                 
                 0.4449 
               
               
                 212886_at 
                 DKFZP434C171 protein 
                 0.2690 
               
               
                 201407_s_at 
                 Protein phosphatase 1, catalytic subunit, beta isoform 
                 0.2653 
               
               
                 212266_s_at 
                 Splicing factor, arginine/serine-rich 5 
                 0.1771 
               
               
                 53912_at 
                 Sorting nexin 11 
                 0.1277 
               
               
                 200090_at 
                 Farnesyltransferase, CAAX box, alpha 
                 0.1167 
               
               
                 218025_s_at 
                 Peroxisomal D3,D2-enoyl-CoA isomerase 
                 0.1032 
               
               
                 204232_at 
                 Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 
                 0.0993 
               
               
                 201722_s_at 
                 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 
                 0.0942 
               
               
                 218627_at 
                 Hypothetical protein FLJ11259 
                 0.0841 
               
               
                 210027_s_at 
                 
                   
                     APEX 
                       
                     nuclease 
                       
                     (multifunctional 
                       
                     DNA 
                       
                     repair 
                       
                     enzyme) 
                       
                     1 
                   
                 
                 0.0817 
               
               
                 202322_s_at 
                 Geranylgeranyl diphosphate synthase 1 
                 0.0646 
               
               
                 221689_s_at 
                 Down syndrome critical region gene 5 
                 0.0549 
               
               
                 203356_at 
                 Calpain 7 
                 0.0535 
               
               
                 211991_s_at 
                 
                   Major histocompatibility complex, class II, DP alpha 1 
                 
                 0.0515 
               
               
                 218462_at 
                 Brix domain containing 5 
                 0.0378 
               
               
                 218123_at 
                 Chromosome 21 open reading frame 59 
                 0.0173 
               
               
                 214329_x_at 
                 Tumor necrosis factor (ligand) superfamily, member 10 
                 −0.0025 
               
               
                 219067_s_at 
                 Chromosome 10 open reading frame 86 
                 −0.0046 
               
               
                 205789_at 
                 CD1D antigen, d polypeptide 
                 −0.0104 
               
               
                 209214_s_at 
                 Ewing sarcoma breakpoint region 1 
                 −0.0111 
               
               
                 213427_at 
                 Ribonuclease P 40 kDa subunit 
                 −0.0471 
               
               
                 209422_at/206567_s_at 
                 PHD finger protein 20 
                 −0.0480/−0.0698 
               
               
                 201010_s_at 
                 Thioredoxin interacting protein 
                 −0.0520 
               
               
                 200883_at 
                 Ubiquinol-cytochrome c reductase core protein II 
                 −0.0521 
               
               
                 218454_at 
                 Hypothetical protein FLJ22662 
                 −0.0544 
               
               
                 202918_s_at 
                 Preimplantation protein 3 
                 −0.0574 
               
               
                 212204_at 
                 DKFZP564G2022 protein 
                 −0.0698 
               
               
                 219452_at 
                 Dipeptidase 2 
                 −0.0800 
               
               
                 209458_x_at 
                 
                   
                     Hemoglobin, 
                       
                     alpha 
                       
                     1, 
                       
                     alpha 
                       
                     2 
                   
                 
                 −0.0809 
               
               
                 219889_at 
                 Frequently rearranged in advanced T-cell lymphomas 
                 −0.0832 
               
               
                 201303_at 
                 DEAD (Asp-Glu-Ala-Asp) box polypeptide 48 
                 −0.0836 
               
               
                 202510_s_at 
                 Tumor necrosis factor, alpha-induced protein 2 
                 −0.0872 
               
               
                 221923_s_at 
                 Nucleophosmin (nucleolar phosphoprotein B23, numatrin) 
                 −0.0902 
               
               
                 201887_at 
                 Interleukin 13 receptor, alpha 1 
                 −0.1075 
               
               
                 211582_x_at 
                 Leukocyte specific transcript 1, LST1 
                 −0.1193 
               
               
                 219030_at 
                 CGI-121 protein 
                 −0.1259 
               
               
                 212706_at 
                 RAS p21 protein activator 4/hypothetical protein FLJ21767 
                 −0.1393 
               
               
                 202902_s_at 
                 Cathepsin S 
                 −0.1644 
               
               
                 200663_at 
                 CD63 antigen (melanoma 1 antigen) 
                 −0.1764 
               
               
                 202138_x_at/209971_x_at 
                 JTV1 gene 
                 −0.1950/−0.2868 
               
               
                 200851_s_at 
                 KIAA0174 
                 −0.2019 
               
               
                 201109_s_at 
                 Thrombospondin 1 
                 −0.2079 
               
               
                 213142_x_at 
                 
                   
                     Hypothetical 
                       
                     protein 
                       
                     LOC54103 
                   
                 
                 −0.2285 
               
               
                 202531_at 
                 Interferon regulatory factor 1 
                 −0.2904 
               
               
                 216274_s_at 
                 SEC11-like 1 ( S. cerevisiae ) 
                 −0.6951 
               
               
                   
               
               
                 Positive RA scores indicate genes overexpressed in RA, 
               
               
                 negative RA scores indicate those underexpressed in RA. 
               
               
                 PAM = Prediction analysis of microarrays; 
               
               
                 bold and underlined letters indicate genes overlapping with the 51 genes identified by Affymetrix ® gene expression profiling and analysis (see Table 3). 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 5 
               
             
            
               
                   
               
               
                 Genes differentially regulated in RA-anti-TNFα responders versus RA-anti-TNFα non-responders (post anti-TNFα therapy) 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 In- 
                 De- 
                   
                   
                   
               
               
                   
                 creased 
                 creased 
                   
                 Fold 
                   
               
               
                 Affymetrix ID 
                 (%) 
                 (%) 
                 Gene title 
                 change 
                 SLR 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 200041_s_at 
                 100 
                 0 
                 HLA-B associated transcript-1 (D6S81E) 
                 2.53 
                 1.34 
               
               
                 200052_s_at 
                 100 
                 0 
                 Interleukin enhancer binding factor 2, 45 kD (ILF2) 
                 3.73 
                 1.90 
               
               
                 200064_at 
                 100 
                 0 
                 Isolate Liv chaperone protein HSP90 beta (HSP90BETA) mRNA 
                 2.66 
                 1.41 
               
               
                 200079_s_at 
                 100 
                 0 
                 Lysyl-tRNA synthetase mRNA, complete cds; nuclear gene for mitochondrial product; 
                 2.16 
                 1.11 
               
               
                   
                   
                   
                 alternatively spliced 
                   
                   
               
               
                 200629_at 
                 100 
                 0 
                 Tryptophanyl-tRNA synthetase (WARS) 
                 2.14 
                 1.10 
               
               
                 200634_at 
                 100 
                 0 
                 Profilin 1 (PFN1), mRNA 
                 2.16 
                 1.11 
               
               
                 200802_at 
                 100 
                 0 
                 Seryl-tRNA synthetase (SARS) 
                 2.20 
                 1.14 
               
               
                 200860_s_at 
                 100 
                 0 
                 Similar to KIAA1007 protein, clone MGC: 692, mRNA, complete cds 
                 2.11 
                 1.08 
               
               
                 200983_x_at 
                 0 
                 100 
                 CD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, 
                 −2.43 
                 −1.28 
               
               
                   
                   
                   
                 EL32 and G344) 
                   
                   
               
               
                 200991_s_at 
                 100 
                 0 
                   Homo sapiens  KIAA0064 gene product (KIAA0064), mRNA 
                 2.71 
                 1.44 
               
               
                 201112_s_at 
                 100 
                 0 
                 Chromosome segregation 1 (yeast homolog)-like (CSE1L), mRNA 
                 2.01 
                 1.01 
               
               
                 201214_s_at 
                 100 
                 0 
                 Protein phosphatase 1, regulatory subunit 7 (PPP1R7), mRNA 
                 2.17 
                 1.12 
               
               
                 201241_at 
                 100 
                 0 
                 DEADH (Asp-Glu-Ala-AspHis) box polypeptide 1 (DDX1), mRNA 
                 2.30 
                 1.20 
               
               
                 201263_at 
                 100 
                 0 
                 Threonyl-tRNA synthetase (TARS), mRNA 
                 2.14 
                 1.10 
               
               
                 201386_s_at 
                 100 
                 0 
                 Dead box protein 15 mRNA, complete cds 
                 2.22 
                 1.15 
               
               
                 201417_at 
                 100 
                 0 
                 SRY (sex determining region Y)-box 4 /DEF = Human DNA sequence from 
                 3.18 
                 1.67 
               
               
                   
                   
                   
                 clone RP3-322L4 on chromosome 6 
                   
                   
               
               
                 201576_s_at 
                 100 
                 0 
                 Galactosidase, beta 1 (GLB1), mRNA 
                 2.00 
                 1.00 
               
               
                 201872_s_at 
                 100 
                 0 
                 ATP-binding cassette, sub-family E (OABP), member 1 
                 2.28 
                 1.19 
               
               
                 201892_s_at 
                 100 
                 0 
                 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6 (14 kD, B14) (NDUFA6), mRNA 
                 2.19 
                 1.13 
               
               
                 202174_s_at 
                 100 
                 0 
                 Pericentriolar material 1 (PCM1), mRNA 
                 2.08 
                 1.06 
               
               
                 202176_at 
                 100 
                 0 
                 Excision repair cross-complementing rodent repair deficiency, complementation 
                 2.93 
                 1.55 
               
               
                   
                   
                   
                 group 3 (ERCC3), mRNA 
                   
                   
               
               
                 202220_at 
                 100 
                 0 
                 KIAA0907 protein (KIAA0907), mRNA 
                 2.39 
                 1.26 
               
               
                 202225_at 
                 100 
                 0 
                 v-crk avian sarcoma virus CT10 oncogene homolog 
                 2.10 
                 1.07 
               
               
                 202464_s_at 
                 0 
                 100 
                 6-phosphofructo-2-kinasefructose-2,6-biphosphatase 3 (PFKFB3), mRNA. /PROD = 6- 
                 −3.25 
                 −1.70 
               
               
                   
                   
                   
                 phosphofructo-2-kinase-fructose-2,6-biphosphatase 3 
                   
                   
               
               
                 202545_at 
                 100 
                 0 
                 KIAA0766 gene product (KIAA0766), mRNA 
                 1.38 
                 0.46 
               
               
                 202838_at 
                 100 
                 0 
                 N-acetylgalactosaminidase, alpha-(NAGA), mRNA 
                 1.82 
                 0.86 
               
               
                 202896_s_at 
                 0 
                 100 
                 Protein tyrosine phosphatase, non-receptor type substrate 1 (PTPNS1), mRNA 
                 −2.00 
                 −1.00 
               
               
                 202950_at 
                 100 
                 0 
                 Crystallin, zeta (quinone reductase) (CRYZ), mRNA 
                 2.51 
                 1.33 
               
               
                 203037_s_at 
                 100 
                 0 
                 KIAA0429 gene product (KIAA0429), mRNA 
                 2.41 
                 1.27 
               
               
                 203155_at 
                 100 
                 0 
                 SET domain, bifurcated 1 (SETDB1), mRNA 
                 4.23 
                 2.08 
               
               
                 203371_s_at 
                 0 
                 100 
                 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3 (12 kD, B12) (NDUFB3), mRNA 
                 −2.13 
                 −1.09 
               
               
                 203821_at 
                 0 
                 100 
                 
                   
                     Diphtheria 
                       
                     toxin 
                       
                     receptor 
                       
                     (DTR) 
                   
                 
                 −3.63 
                 −1.86 
               
               
                 203887_s_at 
                 0 
                 100 
                 
                   Thrombomodulin (THBD), mRNA 
                 
                 −2.75 
                 −1.46 
               
               
                 203966_s_at 
                 0 
                 100 
                 Protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform 
                 −2.73 
                 −1.45 
               
               
                   
                   
                   
                 (PPM1A), mRNA 
                   
                   
               
               
                 204192_at 
                 100 
                 0 
                 CD37 antigen (CD37), mRNA 
                 3.66 
                 1.87 
               
               
                 204419_x_at 
                 0 
                 100 
                 Hemoglobin, gamma G (HBG2), mRNA 
                 −5.50 
                 −2.46 
               
               
                 204566_at 
                 100 
                 0 
                 Protein phosphatase 1D magnesium-dependent, delta isoform (PPM1D), mRNA 
                 2.00 
                 1.00 
               
               
                 204689_at 
                 100 
                 0 
                 Hematopoietically expressed homeobox (HHEX), mRNA 
                 2.04 
                 1.03 
               
               
                 205239_at 
                 0 
                 100 
                 
                   Amphiregulin (schwannoma-derived growth factor) (AREG), mRNA 
                 
                 −3.38 
                 −1.04 
               
               
                 205249_at 
                 0 
                 100 
                 Early growth response 2 (Krox-20 ( Drosophila ) homolog) (EGR2), mRNA 
                 −2.55 
                 −1.35 
               
               
                 205552_s_at 
                 100 
                 0 
                 2,5-oligoadenylate synthetase 1 (40-46 kD) (OAS1), transcript variant E16, mRNA 
                 2.08 
                 1.06 
               
               
                 206115_at 
                 0 
                 100 
                 Early growth response 3 (EGR3), mRNA. /PROD = early growth response 3 
                 −6.54 
                 −2.71 
               
               
                 206584_at 
                 0 
                 100 
                   Homo sapiens  MD-2 protein (MD-2), mRNA 
                 −2.16 
                 −1.11 
               
               
                 206877_at 
                 0 
                 100 
                   Homo sapiens  MAX dimerization protein (MAD), mRNA 
                 −3.92 
                 −1.97 
               
               
                 207170_s_at 
                 100 
                 0 
                 DKFZP586A011 protein (DKFZP586A011), mRNA 
                 2.20 
                 1.14 
               
               
                 208631_s_at 
                 100 
                 0 
                 78 kDa gastrin-binding protein mRNA, complete cds 
                 2.04 
                 1.03 
               
               
                 208691_at 
                 0 
                 100 
                 Transferrin receptor (p90, CD71), clone MGC: 3151, mRNA, complete cds 
                 −2.30 
                 −1.20 
               
               
                 208868_s_at 
                 0 
                 100 
                   Homo sapiens  mRNA; cDNA DKFZp564N1272 (from clone DKFZp564N1272); 
                 −3.18 
                 −1.67 
               
               
                   
                   
                   
                 complete cds 
                   
                   
               
               
                 208869_s_at 
                 0 
                 100 
                 GABA-A receptor-associated protein like 1 (GABARAPL1) mRNA, complete cds 
                 −3.29 
                 −1.72 
               
               
                 208942_s_at 
                 0 
                 100 
                 Translocation protein 1 
                 −2.93 
                 −1.55 
               
               
                 209092_s_at 
                 100 
                 0 
                   Homo sapiens  clone 016b03 My027 protein mRNA, complete cds 
                 2.07 
                 1.05 
               
               
                 209193_at 
                 0 
                 100 
                 Protein kinase-related oncogene (PIM1) mRNA, complete cds 
                 −2.51 
                 −1.33 
               
               
                 209200_at 
                 100 
                 0 
                 MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) 
                 2.48 
                 1.31 
               
               
                 209861_s_at 
                 100 
                 0 
                 eIF-2-associated p67 homolog mRNA, complete cds 
                 2.55 
                 1.35 
               
               
                 209967_s_at 
                 0 
                 100 
                 Human mRNA for hCREM (cyclic AMP-responsive element modulator) type 2 protein, 
                 −3.07 
                 −1.62 
               
               
                   
                   
                   
                 complete cds 
                   
                   
               
               
                 210027_s_at 
                 100 
                 0 
                 Apurinic endonuclease (APE) mRNA, complete cds. /PROD = apurinic endonuclease 
                 2.23 
                 1.16 
               
               
                 210053_at 
                 100 
                 0 
                 TATA box binding protein (TBP)-associated factor, RNA polymerase II, D, 100 kD 
                 2.23 
                 1.16 
               
               
                 210172_at 
                 0 
                 100 
                 Human mRNA for ZFM1 protein alternatively spliced product, complete cds. /PROD = ZFM1 
                 −2.16 
                 −1.11 
               
               
                   
                   
                   
                 protein, alternatively spliced product 
                   
                   
               
               
                 210766_s_at 
                 100 
                 0 
                 Trachea cellular apoptosis susceptibility protein (CSE1) mRNA, complete cds 
                 2.28 
                 1.19 
               
               
                 210949_s_at 
                 100 
                 0 
                 Similar to eukaryotic translation initiation factor 3, subunit 8 (110 kD), clone MGC: 
                 2.53 
                 1.34 
               
               
                   
                   
                   
                 8693, mRNA, complete cds 
                   
                   
               
               
                 211458_s_at 
                 0 
                 100 
                 GABA-A receptor-associated protein mRNA, complete cds. /PROD = GABA-A 
                 −3.18 
                 −1.67 
               
               
                   
                   
                   
                 receptor-associated protein 
                   
                   
               
               
                 211546_x_at 
                 0 
                 100 
                 Human (clone 2-5) synuclein (NACP) mRNA, complete cds 
                 −4.92 
                 −2.30 
               
               
                 212199_at 
                 100 
                 0 
                 Human putative ribosomal protein S1 mRNA 
                 2.22 
                 1.15 
               
               
                 212224_at 
                 100 
                 0 
                 Aldehyde dehydrogenase 1, soluble (ALDH1), mRNA. /PROD = aldehyde dehydrogenase 
                 3.18 
                 1.67 
               
               
                   
                   
                   
                 1, soluble 
                   
                   
               
               
                 212388_at 
                 100 
                 0 
                   Homo sapiens  mRNA for KIAA1057 protein, partial cds 
                 3.10 
                 1.63 
               
               
                 212591_at 
                 100 
                 0 
                 RBP1-like protein 
                 2.03 
                 1.02 
               
               
                 212696_s_at 
                 100 
                 0 
                 Ring finger protein 4 
                 3.05 
                 1.61 
               
               
                 212709_at 
                 100 
                 0 
                 KIAA0197 protein 
                 2.10 
                 1.07 
               
               
                 212714_at 
                 100 
                 0 
                   Homo sapiens  mRNA; cDNA DKFZp586F1323 (from clone DKFZp586F1323) 
                 2.13 
                 1.09 
               
               
                 212893_at 
                 100 
                 0 
                   Homo sapiens  mRNA; cDNA DKFZp564I052 (from clone DKFZp564I052) 
                 2.01 
                 1.01 
               
               
                 212989_at 
                 100 
                 0 
                   Homo sapiens  mRNA for Hmob33 protein, 3 untranslated region 
                 2.25 
                 1.17 
               
               
                 213410_at 
                 100 
                 0 
                   Homo sapiens  mRNA; cDNA DKFZp586F1019 (from clone DKFZp586F1019); partial cds 
                 2.53 
                 1.34 
               
               
                 213515_x_at 
                 0 
                 100 
                 Myosin, light polypeptide 4, alkali; atrial, embryonic 
                 −4.69 
                 −2.23 
               
               
                 213528_at 
                 100 
                 0 
                   H. sapiens  novel gene from PAC 117P20, chromosome 1 
                 2.87 
                 1.52 
               
               
                 213604_at 
                 100 
                 0 
                   Homo sapiens  clone 24582 mRNA sequence 
                 2.07 
                 1.05 
               
               
                 213619_at 
                 0 
                 100 
                 Heterogeneous nuclear ribonucleoprotein H1 (H) 
                 −2.48 
                 −1.31 
               
               
                 213655_at 
                 0 
                 100 
                 Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, 
                 −3.03 
                 −1.60 
               
               
                   
                   
                   
                 epsilon polypeptide 
                   
                   
               
               
                 213743_at 
                 100 
                 0 
                 Cyclin T2 
                 2.08 
                 1.06 
               
               
                 213788_s_at 
                 0 
                 100 
                 cDNA: FLJ23227 fis, clone CAE00645, highly similar to AF052138 
                 −2.20 
                 −1.14 
               
               
                 213872_at 
                 0 
                 100 
                 Hypothetical protein FLJ12619 
                 −4.29 
                 −2.1 
               
               
                 213979_s_at 
                 0 
                 100 
                 C-terminal binding protein 1 
                 −4.41 
                 −2.14 
               
               
                 214257_s_at 
                 0 
                 100 
                 SEC22, vesicle trafficking protein ( S. cerevisiae )-like 1 
                 −2.97 
                 −1.57 
               
               
                 214414_x_at 
                 0 
                 100 
                 Hemoglobin, alpha 1 
                 −2.04 
                 −1.03 
               
               
                 214696_at 
                 0 
                 100 
                   Homo sapiens  clone 24659 mRNA sequence /DEF =  Homo sapiens  clone 24659 
                 −2.93 
                 −1.55 
               
               
                   
                   
                   
                 mRNA sequence 
                   
                   
               
               
                 214933_at 
                 0 
                 100 
                 Calcium channel, voltage-dependent, PQ type, alpha 1A subunit 
                 −2.17 
                 −1.12 
               
               
                 215043_s_at 
                 0 
                 100 
                   H. sapiens  SMA5 mRNA 
                 −4.08 
                 −2.03 
               
               
                 215933_s_at 
                 100 
                 0 
                   H. sapiens  HEX gene encoding homeobox related protein 
                 2.17 
                 1.12 
               
               
                 216199_s_at 
                 100 
                 0 
                 Mitogen-activated protein kinase kinase kinase 4 
                 2.77 
                 1.47 
               
               
                 216202_s_at 
                 100 
                 0 
                 Serine palmitoyltransferase (LCB2) mRNA, partial cds 
                 2.75 
                 1.46 
               
               
                 216996_s_at 
                 100 
                 0 
                 KIAA0971 protein /DEF =  Homo sapiens  cDNA FLJ11495 fis, clone HEMBA1001950, 
                 2.20 
                 1.14 
               
               
                   
                   
                   
                 highly similar to  Homo sapiens  mRNA for KIAA0971 protein 
                   
                   
               
               
                 217554_at 
                 0 
                 100 
                 ESTs, Hs.97109 
                 −3.63 
                 −1.86 
               
               
                 217682_at 
                 0 
                 100 
                 ESTs, Weakly similar to ALU7_HUMAN ALU 
                 −3.01 
                 −1.59 
               
               
                 217840_at 
                 100 
                 0 
                 DEAD-box protein abstrakt (ABS), mRNA 
                 2.39 
                 1.26 
               
               
                 218229_s_at 
                 100 
                 0 
                 KIAA1513 protein (KIAA1513), mRNA 
                 2.07 
                 1.05 
               
               
                 218356_at 
                 100 
                 0 
                 Cell division protein FtsJ (FJH1), mRNA 
                 2.20 
                 1.14 
               
               
                 218432_at 
                 100 
                 0 
                 F-box only protein 3 (FBXO3), mRNA 
                 2.16 
                 1.11 
               
               
                 218589_at 
                 100 
                 0 
                 Purinergic receptor (family A group 5) (P2Y5), mRNA 
                 2.68 
                 1.42 
               
               
                 218604_at 
                 100 
                 0 
                 Integral inner nuclear membrane protein (MAN1), mRNA 
                 2.04 
                 1.03 
               
               
                 218689_at 
                 100 
                 0 
                 Fanconi anemia, complementation group F (FANCF), mRNA 
                 8.94 
                 3.16 
               
               
                 218889_at 
                 100 
                 0 
                 Hypothetical protein FLJ12820 (FLJ12820), mRNA 
                 2.01 
                 1.01 
               
               
                 218973_at 
                 100 
                 0 
                 Hypothetical protein FLJ13119 (FLJ13119), mRNA 
                 2.07 
                 1.05 
               
               
                 219069_at 
                 100 
                 0 
                 Hypothetical protein FLJ20189 (FLJ20189), mRNA 
                 2.23 
                 1.16 
               
               
                 219093_at 
                 100 
                 0 
                 Hypothetical protein FLJ20701 (FLJ20701), mRNA 
                 3.32 
                 1.73 
               
               
                 219099_at 
                 100 
                 0 
                   Homo sapiens  chromosome 12 open reading frame 5 (C12ORF5), mRNA 
                 2.13 
                 1.09 
               
               
                 219176_at 
                 100 
                 0 
                 Hypothetical protein FLJ22555 (FLJ22555), mRNA 
                 2.13 
                 1.09 
               
               
                 219243_at 
                 100 
                 0 
                 Hypothetical protein FLJ11110 (FLJ11110), mRNA 
                 2.07 
                 1.05 
               
               
                 219363_s_at 
                 100 
                 0 
                 CGI-12 protein (LOC51001), mRNA 
                 2.31 
                 1.21 
               
               
                 219434_at 
                 0 
                 100 
                 Triggering receptor expressed on myeloid cells 1 (TREM1), mRNA 
                 −4.35 
                 −2.12 
               
               
                 221485_at 
                 0 
                 100 
                 betaGlcNAc beta 1,4-galactosyltransferase. polypeptide 5 
                 −2.71 
                 −1.44 
               
               
                 221652_s_at 
                 100 
                 0 
                 PNAS-25 mRNA, complete cds. 
                 2.55 
                 1.35 
               
               
                 221755_at 
                 100 
                 0 
                   Homo sapiens  mRNA for FLJ00043 protein, partial cds 
                 3.44 
                 1.09 
               
               
                 221970_s_at 
                 100 
                 0 
                   Homo sapiens  cDNA: FLJ21737 fis, clone COLF3396 
                 2.41 
                 1.27 
               
               
                 222127_s_at 
                 0.1 
                 0 
                   Homo sapiens  cDNA FLJ13399 fis, clone PLACE1001395 /DEF =  Homo sapiens  cDNA 
                 2.31 
                 1.21 
               
               
                   
                   
                   
                 FLJ13399 fis, clone PLACE1001395 
                   
                   
               
               
                 36711_at 
                 0 
                 100 
                 Novel MAFF (v-maf musculoaponeurotic fibrosarcoma (avian) oncogene family, protein F) 
                 −3.54 
                 −1.16 
               
               
                   
                   
                   
                 LIKE protein 
                   
                   
               
               
                 38037_at 
                 0 
                 100 
                 Heparin-binding EGF-like growth factor mRNA, complete cds 
                 −3.63 
                 −1.86 
               
               
                 AFFX-BioB-M_at 
                 0 
                 100 
                   E. coli  7,8-diamino-pelargonic acid (bioA), biotin synthetase (bioB), 7-keto-8-amino- 
                 −4.69 
                 −2.58 
               
               
                   
                   
                   
                 pelargonic acid synthetase (bioF), bioC protein, and dethiobiotin synthetase (bioD), 
                   
                   
               
               
                   
                   
                   
                 complete cds 
                   
                   
               
               
                 AFFX-r2-Ec-bioC- 
                 0 
                 100 
                   Escherichia coli  /REF = J04423 /DEF =  E coli  bioC protein corresponding to 
                 −4.22 
                 −1.86 
               
               
                 3_at 
                   
                   
                 nucleotides 4609-4883 of J04423 /LEN = 777 (−5 and −3 represent transcript 
                   
                   
               
               
                   
                   
                   
                 regions 5 prime and 3 prime respectively) 
               
               
                   
               
               
                 The listed genes (n = 117) show differential expression in 100% of the pairwise comparisons; 
               
               
                 bold and underlined letters indicate genes overlapping with the 51 genes identified by Affymetrix ® gene expression profiling and analysis (see Table 3) 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 6 
               
             
            
               
                   
               
               
                 Correlations between clinical parameters and differentially expressed genes (Pearson correlation 
               
               
                 test; pre- and post-anti-TNFα treatment; n = 7 for all; bold letters identify genes occurring twice, bold and 
               
               
                 italics letters identify genes occurring ≧3 times) 
               
            
           
           
               
               
               
               
               
            
               
                   
                 Affymetrix_ID 
                 Gene title 
                 r-value 
                 p-value 
               
               
                   
               
            
           
           
               
            
               
                 Pre-anti-TNFα treatment 
               
            
           
           
               
               
               
               
               
            
               
                 Leuko/ 
                   202219 _at 
                 
                   Solute carrier family 6 
                 
                 
                   0.901 
                 
                 
                   0.006** 
                 
               
               
                   
                   205239 _at 
                 
                   Amphiregulin 
                 
                 
                   0.879 
                 
                 
                   0.009** 
                 
               
               
                 Thromb/ 
                   205900 _at 
                 
                   Keratin 1 
                 
                 
                   0.923 
                 
                 
                   0.003** 
                 
               
               
                 Mono/ 
                 204018_x_at 
                 Hemoglobin, alpha 1 
                 −0.908 
                 0.005** 
               
               
                 GPT/ 
                   203932 _at 
                 
                   MHC-II, DM beta 
                 
                 
                   −0.912 
                 
                 
                   0.004** 
                 
               
               
                   
                 218589_s_at 
                 Purinergic receptor P2Y, G-protein coupled 5 
                 −0.919 
                 0.003** 
               
               
                 Hb/ 
                   205900 _at 
                 
                   Keratin 1 
                 
                 
                   −0.944 
                 
                 
                   0.001** 
                 
               
               
                 MoStiff/ 
                   202219 _at 
                 
                   Solute carrier family 6 
                 
                 
                   0.893 
                 
                 
                   0.007** 
                 
               
               
                   
                   203932 _at 
                 
                   MHC-II, DM beta 
                 
                 
                   −0.898 
                 
                 
                   0.006** 
                 
               
               
                   
                 204131_s_at 
                 Forkhead box O3A 
                 0.917 
                 0.004** 
               
               
                   
                   205239 _at 
                 
                   Amphiregulin 
                 
                 
                   0.954 
                 
                 
                   0.001** 
                 
               
               
                   
                 207332_s_at 
                 Transferrin receptor (p90, CD71) 
                 0.926 
                 0.003** 
               
               
                   
                 208632_at 
                 Ring finger protein 10 
                 0.913 
                 0.004** 
               
               
                 DisDur/ 
                 212232_at 
                 Formin binding protein 4 
                 0.955 
                 0.001** 
               
               
                   
                 213142_x_at 
                 Hypothetical protein LOC54103 
                 0.877 
                 0.009** 
               
            
           
           
               
            
               
                 Post-anti-TNFα treatment 
               
            
           
           
               
               
               
               
               
            
               
                 ESR/ 
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
                 219228_at 
                 Zinc finger protein 331 
                 0.894 
                 0.007** 
               
               
                 CRP/ 
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                 Thromb/ 
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                 Granulo/ 
                 213427_at 
                 Ribonuclease P 40 kDa subunit 
                 −0.875 
                 0.010** 
               
               
                 Hb/ 
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
                 
                   
                 
                     factor 
                 
                   
                 
                 
                   
                 
               
               
                   
                 203932_at 
                 MHC class II, DM beta 
                 0.885 
                 0.008** 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                 Dis_act/ 
                   36711 _at 
                 
                   v-maf fibrosarc. oncogene homolog F (avian) 
                 
                 
                   0.932 
                 
                 
                   0.002** 
                 
               
               
                   
                   205552 _s_at 
                 
                   2′,5′-oligoadenylate synthetase 1, 40/46 kDa 
                 
                 
                   −0.951 
                 
                 
                   0.001** 
                 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                 DAS28/ 
                 
                   36711 
                 
                 
                   v-maf fibrosarc. oncogene homolog F (avian) 
                 
                 
                   0.940 
                 
                 
                   0.002** 
                 
               
               
                   
                   205552 _s_at 
                 
                   2′,5′-oligoadenylate synthetase 1, 40/46 kDa 
                 
                 
                   −0.898  
                 
                 
                   0.006** 
                 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                   
                 
                   
                 
                 
                   
                 
                 
                   
                 
                 
                   
                 
               
               
                 Sw28/ 
                 219607_s_at 
                 Membrane-spanning 4-domains, subfam. A, memb. 4 
                 0.931 
                 0.002** 
               
               
                   
               
               
                 GPT = glutamate pyruvic transferase; 
               
               
                 Hb = haemoglobin; 
               
               
                 MoStiff = Morning stiffness (minutes); 
               
               
                 DisDur = Disease duration (years); 
               
               
                 ESR = erythrocyte sedimentation rate; 
               
               
                 CRP = C-reactive protein; 
               
               
                 DAS 28 = disease activity score (28 joints); 
               
               
                 Sw = number of swollen joints (28 joints) 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 7 
               
               
                   
               
               
                 TaqMan PCR validation in anti-TNFα-treated RA patients and normal donors 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
            
               
                   
                 PCR 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 RA-αTNF 
                   
                   
               
               
                   
                   
                   
                   
                 (responder) 
               
               
                 Time 
                 Gene 
                   
                   
                 versus ND 
                 Max −ΔRQ 
                 p value 
               
               
                 point 
                 Description 
                 Gene title 
                 Applera ID 
                 (RQ; Means ± SEM) 
                 (Therapy) 
                 (U-Test) 
               
               
                   
               
            
           
           
               
            
               
                 Validated genes 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 BL 
                 AREG 
                 Amphiregulin 
                 Hs00155832_m1 
                 10.23 ± 2.93  
                 −7.60 
                 0.000 
               
               
                 BL 
                 CA-1 
                 Carbonic anhydrase 1 
                 Hs00266139_m1 
                 6.83 ± 3.49 
                 −5.93 
                 n.s. 
               
               
                 BL 
                 CLC 
                 Charcot-Leyden crystal protein 
                 Hs00171342_m1 
                 5.36 ± 4.82 
                 −3.26 
                 0.041 
               
               
                 BL 
                 CLU 
                 Clusterin C 
                 Hs00156548_m1 
                 3.94 ± 2.87 
                 −2.77 
                 n.s. 
               
               
                 BL 
                 TNFAIP6 
                 Tumor necrosis factor alpha 
                 Hs00218482_m1 
                 1.71 ± 0.40 
                 0.82 
                 0.000 
               
               
                   
                   
                 induced protein 6 
               
               
                 BL 
                 THBD 
                 Thrombomodulin 
                 Hs00264920_s1 
                 1.58 ± 1.08 
                 −0.53 
                 0.041 
               
               
                 BL 
                 MS4A4A 
                 Membrane-spanning 4-domains, 
                 Hs00254770_m1 
                 1.54 ± 0.42 
                 0.71 
                 0.041 
               
               
                   
                   
                 subfamily A, member 4 
               
               
                 BL 
                 DTR 
                 Diptheria toxin receptor 
                 Hs00181813_m1 
                 1.21 ± 0.44 
                 −1.10 
                 n.s. 
               
               
                 BL 
                 S100A12 
                 S100 calcium binding protein A1 
                 Hs00194525_m1 
                 1.07 ± 0.21 
                 0.11 
                 0.041 
               
               
                 BL 
                 HT007 
                 Uncharacterized hypothalamus 
                 Hs00218482_m1 
                   0.51 ± −0.09 
                 0.01 
                 0.000 
               
               
                   
                   
                 protein HT007 
               
               
                 BL 
                 HLA-DR 
                 MHC-class-II; HLA-DR alpha 
                 Hs00219578_m1 
                   0.59 ± −0.15 
                 0.09 
                 0.000 
               
               
                 BL 
                 LOC54103 
                 Hypothetical protein LOC54103 
                 Hs00367929_m1 
                   0.90 ± −0.21 
                 −0.24 
                 0.041 
               
               
                 BL 
                 TNF 
                 Tumor necrosis factor alpha 
                 Hs00174128_m1 
                 1.22 ± 0.53 
                 −0.84 
                 0.041 
               
               
                 BL 
                 IL1B 
                 Interleukin 1 beta 
                 Hs00174097_m1 
                 1.14 ± 0.42 
                 −0.28 
                 0.041 
               
               
                 BL 
                 PSMB7 
                 Proteasome subunit beta type 7 
                 Hs00160607_m1 
                   0.72 ± −0.19 
                 0.16 
                 0.041 
               
               
                   
                   
                 precursor 
               
               
                 BL 
                 KIAA0174 
                 Protein KIAA0174 
                 Hs00796085_sh 
                 0.89 ± 0.30 
                 0.08 
                 0.041 
               
               
                 BL 
                 SPC18 
                 Microsomal signal peptidase 
                 Hs00819308_m1 
                 0.96 ± 0.11 
                 −0.25 
                 0.041 
               
               
                   
                   
                 18 kDa subunit 
               
            
           
           
               
            
               
                 Discrepancies between Affymetrix and TaqMan PCR 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 BL 
                 LIPT1 
                 Lipoyltransferase 1 
                 Hs00376962_m1 
                 2.17 ± 0.54 
                 −0.68 
                 0.000 
               
               
                 BL 
                 ZNF361 
                 Ring zinc finger protein 361 
                 Hs00367929_m1 
                   0.55 ± −0.11 
                 −0.14 
                 0.000 
               
               
                 BL 
                 THBS1 
                 Thrombospondin-1 
                 Hs00170236_m1 
                 0.88 ± 0.25 
                 −0.34 
                 n.s. 
               
               
                 BL 
                 IRF1 
                 Interferon regulatory protein 1 
                 Hs00233698_m1 
                 4.95 ± 0.18 
                 3.37 
                 0.000 
               
               
                 BL 
                 PPP1CB 
                 Protein phosphatase 1, catalytic 
                 Hs00160349_m1 
                 0.93 ± 0.09 
                 −0.28 
                 0.041 
               
               
                   
                   
                 subunit, beta isoform 
               
               
                   
               
            
           
           
               
               
            
               
                   
                 Affymetrix 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                 RA-αTNF 
                 FC RA-αTNF 
                   
                 FC RA-αTNF 
               
               
                   
                   
                   
                 (responder) 
                 (responder) 
                 RA-αTNF all 
                 all 
               
               
                   
                 Time 
                 Affymetrix 
                 versus ND 
                 versus ND 
                 versus ND 
                 versus ND 
               
               
                   
                 point 
                 ID 
                 (% of comp.) 
                 (Means) 
                 (% of comp.) 
                 (Means) 
               
               
                   
                   
               
            
           
           
               
               
            
               
                   
                 Validated genes 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                 BL 
                 205239_at 
                 82.86 
                 5.48 
                 81.63 
                 6.13 
               
               
                   
                 BL 
                 205950_s_at 
                 88.57 
                 4.92 
                 81.63 
                 5.88 
               
               
                   
                 BL 
                 206207_at 
                 62.86 
                 2.46 
                 73.47 
                 3.97 
               
               
                   
                 BL 
                 222043_at 
                 68.57 
                 2.57 
                 75.51 
                 2.68 
               
               
                   
                 BL 
                 206026_s_at 
                 62.86 
                 2.07 
                 73.27 
                 2.24 
               
               
                   
                 BL 
                 203887_s_at 
                 74.29 
                 2.64 
                 71.43 
                 2.49 
               
               
                   
                 BL 
                 219607_s_at 
                 88.57 
                 2.66 
                 91.84 
                 2.96 
               
               
                   
                 BL 
                 38037_at 
                 68.57 
                 2.91 
                 71.43 
                 2.87 
               
               
                   
                 BL 
                 205863_at 
                 62.86 
                 1.50 
                 71.43 
                 1.69 
               
               
                   
                 BL 
                 221622_s_at 
                 −88.57 
                 −1.74 
                 −85.71 
                 −1.66 
               
               
                   
                 BL 
                 208894_at 
                 −65.71 
                 −1.77 
                 −75.51 
                 −2.15 
               
               
                   
                 BL 
                 222150_s_at 
                 −80.00 
                 −1.84 
                 −73.47 
                 −1.71 
               
               
                   
                 BL 
                 207113_s_at 
                 34.29 
                 1.03 
                 −46.94 
                 −1.28 
               
               
                   
                 BL 
                 205067_at 
                 57.14 
                 1.62 
                 57.02 
                 1.44 
               
               
                   
                 BL 
                 200786_at 
                 −54.29 
                 −1.27 
                 −57.74 
                 −1.27 
               
               
                   
                 BL 
                 200851_s_at 
                 −42.86 
                 −1.17 
                 −46.94 
                 −1.23 
               
               
                   
                 BL 
                 201290_at 
                 −17.14 
                 −1.04 
                 −72.24 
                 −1.03 
               
            
           
           
               
               
            
               
                   
                 Discrepancies between Affymetrix and TaqMan PCR 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                 BL 
                 205571_at 
                 −74.29 
                 −1.74 
                 −79.59 
                 −1.90 
               
               
                   
                 BL 
                 219228_at 
                 77.14 
                 4.19 
                 77.55 
                 3.94 
               
               
                   
                 BL 
                 201110_s_at 
                 85.71 
                 16.35 
                 77.55 
                 12.60 
               
               
                   
                 BL 
                 202531_at 
                 −40.00 
                 −1.30 
                 −55.70 
                 −1.44 
               
               
                   
                 BL 
                 201409_s_at 
                 60.00 
                 1.63 
                 57.14 
                 1.69 
               
               
                   
                   
               
               
                   
                 Validation of 22 selected genes from Affymetrix ® gene expression profiling by Taqman real-time RT-PCR (10 anti-TNFα-treated RA patients prior to therapy; 14 normal donors − ND); genes differentially expressed (decreased: &lt;−70%; increased: &gt;70%) in RA versus ND according to the Affymetrix ® analysis are shown in normal type, equally-expressed genes are displayed in italics; RQ = relative quantity; FC = fold-change; BL = baseline (pre-antiTNFα therapy) 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 8 
               
             
            
               
                   
               
               
                 Correlations between TaqMan PCR results and the 
               
               
                 ACR response in anti-TNFα-treated RA patients 
               
            
           
           
               
               
               
               
               
               
               
            
               
                 Gene 
                 Time 
                   
                   
                   
                   
                   
               
               
                 description 
                 point 
                 Gene title 
                 Applera ID 
                 r-value 
                 p 
                 n 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 CA1 
                 w 12 
                 Carbonic anhydrase 1 
                 Hs00266139_m1 
                 0.642 
                 0.045 
                 10 
               
               
                 CA1 
                 w 26 
                   
                   
                 0.962 
                 0.000 
                 9 
               
               
                 CLC 
                 w 4 
                 Charcot-Leyden crystal protein 
                 Hs00171342_m1 
                 0.766 
                 0.027 
                 8 
               
               
                 THBD 
                 w 4 
                 Thrombomodulin 
                 Hs00264920_s1 
                 0.766 
                 0.027 
                 8 
               
               
                 THBS1 
                 w 26 
                 Thrombospondin 1 
                 Hs00170236_m1 
                 −0.710 
                 0.032 
                 9 
               
               
                 IRF1 
                 w 4 
                 Interferon regulatory factor 1 
                 Hs00233698 m1 
                 0.778 
                 0.023 
                 8 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 9 
               
             
            
               
                   
               
               
                 Genes differentially regulated in RA-anti-TNFα responders versus RA-anti-TNFα non-responders (pre-anti-TNFα therapy; 
               
               
                 predictive genes) 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                 Increased 
                 Decreased 
                 Fold- 
                   
               
               
                 Affymetrix ID 
                 Gene title 
                 (%) 
                 (%) 
                 Change 
                 SLR 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 39248_at 
                 Aquaporin 3 
                 10 
                 
                   80 
                 
                 −4.6 
                 −2.19 
               
               
                 200061_s_at 
                 Similar to ribosomal protein S24, clone MGC: 8595 
                 0 
                 
                   80 
                 
                 −1.39 
                 −0.47 
               
               
                 200087_s_at 
                 Transmembrane emp24 domain trafficking protein 2 
                 0 
                 
                   80 
                 
                 −1.6 
                 −0.63 
               
               
                 200642_at 
                 Superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 
                 0 
                 
                   80 
                 
                 −1.8 
                 −0.84 
               
               
                 200655_s_at 
                 Calmodulin 1 (phosphorylase kinase, delta) 
                 0 
                 
                   80 
                 
                 −1.5 
                 −0.59 
               
               
                 200745_s_at 
                 Guanine nucleotide binding protein (G protein), beta polypeptide 1 
                 
                   80 
                 
                 0 
                 1.6 
                 0.66 
               
               
                 200772_x_at 
                 Prothymosin, alpha (gene sequence 28) 
                 
                   80 
                 
                 0 
                 1.7 
                 0.75 
               
               
                 201193_at 
                   Homo sapiens  isocitrate dehydrogenase 1 (NADP+) soluble (IDH1) 
                 0 
                 
                   80 
                 
                 −1.4 
                 −0.49 
               
               
                 201690_s_at 
                 Tumor protein D52 
                 0 
                 
                   80 
                 
                 −3.3 
                 −1.73 
               
               
                 201693_s_at 
                 Early growth response 1 
                 
                   80 
                 
                 0 
                 3.1 
                 1.61 
               
               
                 201889_at 
                 
                   
                 
                 0 
                 
                   
                 
                 −1.7 
                 −0.74 
               
               
                 202110_at 
                 Cytochrome c oxidase subunit VIIb 
                 0 
                 
                   80 
                 
                 −1.6 
                 −0.64 
               
               
                 202157_s_at 
                 CUG triplet repeat, RNA binding protein 2 
                 0 
                 
                   80 
                 
                 −1.6 
                 −0.64 
               
               
                 202233_s_at 
                 Ubiquinol-cytochrome c reductase hinge protein 
                 0 
                 
                   80 
                 
                 −1.7 
                 −0.74 
               
               
                 202378_s_at 
                 Homos spaiens leptin receptor gene-related protein (HS0BRGRP) 
                 
                   80 
                 
                 20 
                 1.15 
                 0.20 
               
               
                 202664_at 
                 Wiskott-Aldrich syndrome protein interacting protein 
                 
                   80 
                 
                 0 
                 1.9 
                 0.91 
               
               
                 202910_s_at 
                 CD97 antigen 
                 
                   80 
                 
                 10 
                 1.6 
                 0.70 
               
               
                 202922_at 
                 Glutamate-cysteine ligase, catalytic subunit 
                 0 
                 
                   80 
                 
                 −2.3 
                 −1.17 
               
               
                 202950_at 
                 Crystallin, zeta (quinone reductase) 
                 
                   80 
                 
                 0 
                 2.2 
                 1.16 
               
               
                 203097_s_at 
                 Rap guanine nucleotide exchange factor (GEF) 2 
                 20 
                 
                   80 
                 
                 −1.3 
                 −0.38 
               
               
                 203231_s_at 
                 Ataxin 1 
                 0 
                 
                   80 
                 
                 −8.2 
                 −3.03 
               
               
                 203300_x_at 
                 Adaptor-related protein complex 1, sigma 2 subunit 
                 
                   80 
                 
                 20 
                 1.9 
                 0.89 
               
               
                 204160_s_at 
                 Ectonucleotide pyrophosphatase/phosphodiesterase 4 
                 10 
                 
                   80 
                 
                 −2.4 
                 −1.27 
               
               
                 204750_s_at 
                 Desmocollin 2 
                 
                   80 
                 
                 0 
                 12.9 
                 3.69 
               
               
                 204777_s_at 
                 MAL, T-cell differentiation protein 
                 10 
                 
                   80 
                 
                 −2.6 
                 −1.39 
               
               
                 205042_at 
                 Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 
                 0 
                 
                   80 
                 
                 −1.9 
                 −0.95 
               
               
                 205114_s_at 
                 Chemokine (C—C motif) ligand 3 
                 
                   80 
                 
                 0 
                 2.0 
                 0.96 
               
               
                 205624_at 
                 Carboxypeptidase A3 
                 0 
                 
                   80 
                 
                 −4.0 
                 −2.00 
               
               
                 206207_at 
                 Charcot-Leyden crystal protein 
                 0 
                 
                   
                 
                 −4.9 
                 −2.29 
               
               
                 206790_s_at 
                 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7 kDa 
                 0 
                 
                   80 
                 
                 −1.5 
                 −0.61 
               
               
                 207008_at 
                 Interleukin 8 receptor, beta 
                 
                   
                 
                 0 
                 4.0 
                 2.00 
               
               
                 207815_at 
                 Platelet factor 4 variant 1 
                 20 
                 
                   80 
                 
                 −2.4 
                 −1.28 
               
               
                 208051_s_at 
                 Poly(A) binding protein interacting protein 1 
                 0 
                 
                   80 
                 
                 −1.6 
                 −0.68 
               
               
                 208161_s_at 
                 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 
                 
                   80 
                 
                 0 
                 4.3 
                 2.10 
               
               
                 208637_x_at 
                 Actinin, alpha 1 
                 
                   80 
                 
                 0 
                 2.4 
                 1.24 
               
               
                 208918_s_at 
                 NAD kinase 
                 
                   80 
                 
                 0 
                 1.5 
                 0.59 
               
               
                 208982_at 
                 Platelet/endothelial cell adhesion molecule (CD31 antigen) 
                 
                   
                 
                 0 
                 1.6 
                 0.71 
               
               
                 209009_at 
                 Esterase D/formylglutathione hydrolase 
                 
                   80 
                 
                 20 
                 1.5 
                 0.54 
               
               
                 209020_at 
                 Chromosome 20 open reading frame 111 
                 
                   80 
                 
                 20 
                 1.5 
                 0.54 
               
               
                 209146_at 
                 Sterol-C4-methyl oxidase-like 
                 0 
                 
                   80 
                 
                 −1.9 
                 −0.89 
               
               
                 209193_at 
                 PIM-1 oncogene 
                 10 
                 
                   80 
                 
                 −2.3 
                 −1.19 
               
               
                 209710_at 
                 GATA binding protein 2 
                 20 
                 
                   80 
                 
                 −3.5 
                 −1.81 
               
               
                 210042_s_at 
                 Cathepsin Z 
                 
                   80 
                 
                 20 
                 1.9 
                 0.94 
               
               
                 210184_at 
                 
                   
                 
                 
                   
                 
                 0 
                 2.3 
                 1.22 
               
               
                 210732_s_at 
                 Lectin, galactoside-binding, soluble, 8 (galectin 8) 
                 
                   80 
                 
                 0 
                 2.4 
                 1.23 
               
               
                 210895_s_at 
                 CD86 antigen (CD28 antigen ligand 2, B7-2 antigen) 
                 
                   80 
                 
                 10 
                 1.9 
                 0.92 
               
               
                 211506_s_at 
                 Interleukin 8 
                 
                   
                 
                 0 
                 3.2 
                 1.67 
               
               
                 211734_s_at 
                 Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide 
                 0 
                 
                   80 
                 
                 −5.0 
                 −2.31 
               
               
                 211995_x_at 
                 Actin, gamma 1 
                 
                   80 
                 
                 0 
                 1.4 
                 0.46 
               
               
                 212314_at 
                 KIAA0746 protein 
                 10 
                 
                   80 
                 
                 −1.7 
                 −0.73 
               
               
                 212335_at 
                 Glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) 
                 
                   80 
                 
                 0 
                 1.5 
                 0.54 
               
               
                 212386_at 
                 Transcription factor 4 
                 0 
                 
                   80 
                 
                 −2.5 
                 −1.29 
               
               
                 212671_s_at 
                 Major histocompatibility complex, class II, DQ alpha 1 
                 10 
                 
                   80 
                 
                 −3.3 
                 −1.72 
               
               
                 212897_at 
                 Cell division cycle 2-like 6 (CDK8-like) 
                 
                   80 
                 
                 0 
                 1.8 
                 0.83 
               
               
                 212999_x_at 
                 Major histocompatibility complex, class II, DQ beta 1 
                 
                   80 
                 
                 20 
                 1.8 
                 0.88 
               
               
                 213309_at 
                 Phospholipase C-like 2 
                 0 
                 
                   80 
                 
                 −1.9 
                 −0.9 
               
               
                 213506_at 
                 Coagulation factor II (thrombin) receptor-like 1 
                 
                   80 
                 
                 0 
                 2.4 
                 1.23 
               
               
                 213883_s_at 
                 TM2 domain containing 1 
                 10 
                 
                   80 
                 
                 −1.4 
                 −0.46 
               
               
                 214305_s_at 
                 Splicing factor 3b, subunit 1, 155 kDa 
                 
                   80 
                 
                 20 
                 1.5 
                 0.62 
               
               
                 214512_s_at 
                 SUB1 homolog ( S. cerevisiae ) 
                 0 
                 
                   80 
                 
                 −1.7 
                 −0.76 
               
               
                 214807_at 
                 MRNA; cDNA DKFZp564O0862 
                 
                   80 
                 
                 10 
                 1.7 
                 0.79 
               
               
                 214953_s_at 
                 Amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer 
                 
                   
                 
                 0 
                 1.9 
                 0.93 
               
               
                   
                 disease) 
                   
                   
                   
                   
               
               
                 215726_s_at 
                 Cytochrome b-5 
                 0 
                 
                   80 
                 
                 −2.1 
                 −1.08 
               
               
                 216016_at 
                 Cold autoinflammatory syndrome 1 
                 
                   80 
                 
                 0 
                 6.1 
                 2.60 
               
               
                 217722_s_at 
                 Neugrin, neurite outgrowth associated 
                 0 
                 
                   
                 
                 −1.9 
                 −0.91 
               
               
                 217753_s_at 
                 Ribosomal protein S26, 40S ribosomal protein 
                 10 
                 
                   80 
                 
                 −2.9 
                 −1.51 
               
               
                 217970_s_at 
                 CCR4-NOT transcription complex, subunit 6 
                 0 
                 
                   80 
                 
                 −1.9 
                 −0.91 
               
               
                 218190_s_at 
                 Ubiquinol-cytochrome c reductase complex (7.2 kD) 
                 0 
                 
                   80 
                 
                 −2.0 
                 −1.03 
               
               
                 218345_at 
                 Hepatocellular carcinoma-associated antigen 112 
                 10 
                 
                   80 
                 
                 −3.9 
                 −1.95 
               
               
                 218486_at 
                 Kruppel-like factor 11 
                 
                   
                 
                 0 
                 2.1 
                 1.06 
               
               
                 218545_at 
                 GGA binding partner 
                 0 
                 
                   80 
                 
                 −1.6 
                 −0.67 
               
               
                 218728_s_at 
                 Cornichon homolog 4 ( Drosophila ) 
                 0 
                 
                   80 
                 
                 −1.8 
                 −0.84 
               
               
                 219269_at 
                 Hypothetical protein FLJ21616 
                 0 
                 
                   90 
                 
                 −2.1 
                 −1.06 
               
               
                 219410_at 
                 
                   
                 
                 0 
                 
                   
                 
                 −4.7 
                 −2.33 
               
               
                 219862_s_at 
                 Nuclear prelamin A recognition factor 
                 
                   80 
                 
                 0 
                 1.5 
                 0.62 
               
               
                 219905_at 
                 Erythroblast membrane-associated protein 
                 0 
                 
                   80 
                 
                 −1.8 
                 −0.85 
               
               
                 220532_s_at 
                 LR8 protein 
                 10 
                 
                   80 
                 
                 −5.2 
                 −2.39 
               
               
                 221011_s_at 
                 Likely ortholog of mouse limb-bud and heart gene (LBH) 
                 0 
                 
                   80 
                 
                 −2.8 
                 −1.47 
               
               
                 221042_s_at 
                 Calmin (calponin-like, transmembrane) 
                 
                   80 
                 
                 0 
                 1.9 
                 0.89 
               
               
                 221434_s_at 
                 Chromosome 14 open reading frame 156 
                 0 
                 
                   80 
                 
                 −1.7 
                 −0.72 
               
               
                 221737_at 
                 Guanine nucleotide binding protein (G protein) alpha 12 
                 10 
                 
                   80 
                 
                 −2.0 
                 −1.96 
               
               
                 AFFX-M27830_5_at 
                 SRY (sex determining region Y)-box 18 
                 
                   80 
                 
                 0 
                 4.3 
                 2.09 
               
               
                   
               
               
                 The criterion for gene selection (total of 82) was the percentage of pairwise comparisons between future RA responders and future RA non-responders to anti-TNFα therapy showing an increase or decrease for the fold-change/Signal Log Ratio prior to therapy; bold letters indicate a percentage of 80% for the pairwise comparisons (total of 10), bold and italic letters    , bold, italic, and underlined letters    in the latter case, also the gene names are shown in bold, italic, and underlined letters. 
               
            
           
         
       
     
     
       
         
           
               
            
               
                   
               
               
                 SUMMARY OF SEQUENCE LISTING 
               
            
           
           
               
               
               
            
               
                 SEQ ID NO: 
                 AffymetrixID 
                 Sequence 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 1 
                 39248_at 
                 cttctacaggcttttgggaagtagggtggatgtg 
                   
               
               
                   
                   
                 ggtagggctgggaggagggggccacagcttaggt 
               
               
                   
                   
                 ttggagctctggatgtacatacataagtaggagc 
               
               
                   
                   
                 agtgggacgtgtttctgtcataatgcaggcatga 
               
               
                   
                   
                 agggtggagtgaagtcaggtcataagtttcatgt 
               
               
                   
                   
                 ttgcttttgttttgttttgtttttaatgtatgta 
               
               
                   
                   
                 gcagatgttacagtcttagggatccgggatggga 
               
               
                   
                   
                 gaccccactttagaaagggtcgtcactcctttaa 
               
               
                   
                   
                 tcctcta 
               
               
                   
               
               
                 2 
                 200061_s_at 
                 agatcgccatcatgaacgacaccgtaactatccgcactag 
               
               
                   
                   
                 aaagttcatgaccaaccgactacttcagaggaaacaaatg 
               
               
                   
                   
                 gtcattgatgtccttcaccccgggaaggcgacagtgccta 
               
               
                   
                   
                 agacagaaattcgggaaaaactagccaaaatgtacaagac 
               
               
                   
                   
                 cacaccggatgtcatctttgtatttggattcagaactcat 
               
               
                   
                   
                 tttggtggtggcaagacaactggctttggcatgatttatg 
               
               
                   
                   
                 attccctggattatgcaaagaaaaatgaacccaaacatag 
               
               
                   
                   
                 acttgcaagacatggcctgtatgagaagaaaaagacctca 
               
               
                   
                   
                 agaaagcaacgaaaggaacgcaagaacagaatgaagaaag 
               
               
                   
                   
                 tcagggggactgcaaaggccaatgttggtgctggcaaaaa 
               
               
                   
                   
                 gtgagctggagattggatcacagccgaaggagtaaaggtg 
               
               
                   
                   
                 ctgcaatgatgttagctgtggccactgtggatttttcgca 
               
               
                   
                   
                 aga 
               
               
                   
               
               
                 3 
                 200087_s_at 
                 gggtactgaccatcagtgtcagcattagggtttt 
               
               
                   
                   
                 ggtttttgtttcttttgggtatttcttttttggc 
               
               
                   
                   
                 acatgtgaatcttgttttgtgtaaaatgaaatta 
               
               
                   
                   
                 ctttctcttgttctctgatgatgggtttaaaatt 
               
               
                   
                   
                 aaaagagcatccggttttggtatggggatgatcc 
               
               
                   
                   
                 aggattatgttgtgactgatacatattagttact 
               
               
                   
                   
                 tgtgctttttttttttttttttnggatctttgca 
               
               
                   
                   
                 agggcaaaactacaagtaacgagttttatataat 
               
               
                   
                   
                 taatttaaatttgttacaggttttcatgttcagg 
               
               
                   
                   
                 ataaaccatacttccaccttgggtgagaacactt 
               
               
                   
                   
                 gcaacagtttattaatgaggtgactttcacctta 
               
               
                   
                   
                 ggacaactgttgcatgccaagttttttgtgtgtg 
               
               
                   
                   
                 tgaaacacttcaaaactgatttaaaagatgtaaa 
               
               
                   
                   
                 tttaaaattggttgtatctaatatgccccagg 
               
               
                   
               
               
                 4 
                 200642_at 
                 ctgaagggcgacggcccagtgcagggcatcatcaatttcg 
               
               
                   
                   
                 agcagaaggaaagtaatggaccagtgaaggtgtggggaag 
               
               
                   
                   
                 cattaaaggactgactgaaggcctgcatggattccatgtt 
               
               
                   
                   
                 catgagtttggagataatacggcaggctgtaccagtgcag 
               
               
                   
                   
                 gtcctcactttaatcctctatccagaaaacacggtgggcc 
               
               
                   
                   
                 aaaggatgaagagaggcatgttggagacttgggcaatgtg 
               
               
                   
                   
                 actgctgacaaagatggtgtggccgatgtgtctattgaag 
               
               
                   
                   
                 attctgtgatctcactctcaggagaccattgcatcattgg 
               
               
                   
                   
                 ccgcacactggtggtccatgaaaaagcagatgacttgggc 
               
               
                   
                   
                 aaaggtggaaatgaagaaagtacaaagacaggaaacgctg 
               
               
                   
                   
                 gaagtcgtttggcttgtggtgtaattgggatcgcccaata 
               
               
                   
                   
                 aacattcccttg 
               
               
                   
               
               
                 5 
                 200655_s_at 
                 acctattcaaatgggttctagttcaatttgttta 
               
               
                   
                   
                 gtataaattgtcatagctggtttactgaaaacaa 
               
               
                   
                   
                 acacatttaaaattggtttacctcaggatgacgt 
               
               
                   
                   
                 gcagaaaaatgggtgaaggataaaccgttgagac 
               
               
                   
                   
                 gtggccccactggtaggatggtcctcttgtactt 
               
               
                   
                   
                 cgtgtgctccgacccatggtgacgatgacacacc 
               
               
                   
                   
                 ctggtggcatgcccgtgtatgttggtttagcgtt 
               
               
                   
                   
                 gtctgcattgttctagagtgaaacaggtgtcagg 
               
               
                   
                   
                 ctgtcactgttcacacaaatttttaataagaaac 
               
               
                   
                   
                 atttaccaagggagcatctttggactctctgttt 
               
               
                   
                   
                 ttaaaaccttctgaaccatgacttggagccggca 
               
               
                   
                   
                 gagtaggctgtggctgtggacttcagcacaacca 
               
               
                   
                   
                 tcaacattgctgttcaaagaaattacagtttacg 
               
               
                   
                   
                 tccattccaagttgt 
               
               
                   
               
               
                 6 
                 200745_s_at 
                 gcgtgatcagagaatccttcaccttatgctgaaaagtgag 
               
               
                   
                   
                 ctcagatccagcaccaatgttcctcctgacccatcctgtc 
               
               
                   
                   
                 tatcttctcagttgagtttttaatctcactttgggtttcc 
               
               
                   
                   
                 ttgtgaagttggagggaagtttataatagcctaacactac 
               
               
                   
                   
                 cccacccccaactaggaggaacctctgttttcaagagaga 
               
               
                   
                   
                 tgcctgtcctgtgcttggatagtcagtcaattatttgtgt 
               
               
                   
                   
                 atgaaacaatgtacaaatcaatgttttgaaaataatgatc 
               
               
                   
                   
                 tcagactttctaagttaaagttttaaaaattttgattgtt 
               
               
                   
                   
                 tgccatattgggtgggtttactcttagaatcgcatgctgt 
               
               
                   
                   
                 agaaaatgctcaaaagtgcatatgggactcagtccttagg 
               
               
                   
                   
                 tgttctttttcttttaagaaataacctcttacagttgtaa 
               
               
                   
                   
                 ccattgcggctctgtccacttctcgttgctgctctgtggc 
               
               
                   
                   
                 acatatcggaagcagtacagcgcgcgg 
               
               
                   
               
               
                 7 
                 200772_x_at 
                 gaaaagccatctttgcattgttcctcatccgncc 
               
               
                   
                   
                 tccttgctcngccgcagccgcctccgccgcgcgc 
               
               
                   
                   
                 ctcctccgccgccgcggactnccggcagctttat 
               
               
                   
                   
                 cgccagagtccctgaactctcgctttctttttaa 
               
               
                   
                   
                 tccccntgcatcggatcaccggcgtgccccacca 
               
               
                   
                   
                 tgtcagacgcagccgtagacaccagctccgaaat 
               
               
                   
                   
                 caccaccaaggacttaaaggagaagaaggaagtt 
               
               
                   
                   
                 gtggaagaggcagaaanatggaagaganncgccc 
               
               
                   
                   
                 ctgctnaacgggnaatgctnnananantgaggaa 
               
               
                   
                   
                 naatggggnagcaggaggctngacaatngaggta 
               
               
                   
                   
                 gacgaangaaganggaagananggtggggangga 
               
               
                   
                   
                 angagganggagganagaangaaggtgantggtg 
               
               
                   
                   
                 anggaangaggantggangantgaangatgagga 
               
               
                   
                   
                 agctgagtcagctacgggcaagcgggcagctgaa 
               
               
                   
                   
                 ngatgatgaggatgacgatgtcgataccaangaa 
               
               
                   
                   
                 gcagaagaccgacgaggatgactagacagc 
               
               
                   
               
               
                 8 
                 201193_at 
                 tagccacagtattgctccctaaaatatgcataaagtagaa 
               
               
                   
                   
                 attcactgccttcccctcctgtccatgaccttgggcacag 
               
               
                   
                   
                 ggaagttctggtgtcatagatatcccgttttgtgaggtag 
               
               
                   
                   
                 agctgtgcattaaacttgcacatgactggaacgaagtatg 
               
               
                   
                   
                 agtgcaactcaaatgtgttgaagatactgcagtcattttt 
               
               
                   
                   
                 gtaaagaccttgctgaatgtttccaatagactaaatactg 
               
               
                   
                   
                 tttaggccgcaggagagtttggaatccggaataaatacta 
               
               
                   
                   
                 cctggagtcttgtcctctccatttttctctttctcctcct 
               
               
                   
                   
                 ggcctggcctgaatattatactactctaaatagcatattt 
               
               
                   
                   
                 catccaagtgcaataatgtaagctgaatcttttttggact 
               
               
                   
                   
                 tctgctggcctgttttatttcttttatataaatgtgattt 
               
               
                   
                   
                 ctcagaaattgatattaaacactatcttatcttctcctga 
               
               
                   
                   
                 actgttgatttt 
               
               
                   
               
               
                 9 
                 201690_s_at 
                 atgatactgtagaacctgtctcctactttgaaaa 
               
               
                   
                   
                 ctgaatgtcagggctgagtgaatcaaagtgtcta 
               
               
                   
                   
                 gacatatttgcatagaggccaaggtattctattc 
               
               
                   
                   
                 taataactgcttactcaacactaccaccttttcc 
               
               
                   
                   
                 ttatactgtatatgattatggcctacaatgttgt 
               
               
                   
                   
                 atttgttatttattaaattgtgattgttttatta 
               
               
                   
                   
                 ttgtttatgccaaatgttaactgccaagcttgga 
               
               
                   
                   
                 gtgacctaaagcattttttaaaagcatggctaga 
               
               
                   
                   
                 tttacttcagtataaattatcttatgaaaaccaa 
               
               
                   
                   
                 attttaaaagccacaggtgttgattgttataaaa 
               
               
                   
                   
                 taacatgctgccattcttgattgctagagttttt 
               
               
                   
                   
                 gttagtactttggatgc 
               
               
                   
               
               
                 10 
                 201693_s_at 
                 gggctttcggacatgacagcaaccttttctccca 
               
               
                   
                   
                 ggacaattgaaatttgctaaagggaaaggggaaa 
               
               
                   
                   
                 gaaagggaaaagggagaaaaagaaacacaagaga 
               
               
                   
                   
                 cttaaaggacaggaggaggagatggccataggag 
               
               
                   
                   
                 aggagggttcctcttaggtcagatggaggttctc 
               
               
                   
                   
                 agagccaagtcctccctctctactggagtggaag 
               
               
                   
                   
                 gtctattggccaacaatcctttctgcccacttcc 
               
               
                   
                   
                 ccttccccaattactattccctttgacttcagct 
               
               
                   
                   
                 gcctgaaacagccatgtccaagttcttcacctct 
               
               
                   
                   
                 atccaaagaacttgatttgcatggattttggata 
               
               
                   
                   
                 aatcatttcagtatcatctccatcatatgcctga 
               
               
                   
                   
                 ccccttgctcccttcaatgctagaaaatcgagtt 
               
               
                   
                   
                 ggcaaaatggggtttgggcccctcagagccctgc 
               
               
                   
                   
                 cctgcacccttgtacagtgtctgtgccatggatt 
               
               
                   
                   
                 tcgtttttcttggggtactcttgatt 
               
               
                   
               
               
                 11 
                 201889_at 
                 Ttgaccccaaatgactttatacccaattctacataaaaat 
               
               
                   
                   
                 atagaagatctatctttttttgttaccttcagatgttcac 
               
               
                   
                   
                 taaataactcagtttttaagcagaagttttcagggcatta 
               
               
                   
                   
                 aatatatgttgtgtatgaagtatctcaaactggaacataa 
               
               
                   
                   
                 atttagtgatcaaactgccattcacagtgtaaggcagcac 
               
               
                   
                   
                 ttaaatttcgaacctaaagtttagatgcattgtataaaaa 
               
               
                   
                   
                 aacctaaaagcagtatctgttatttagctgtaaaccaagt 
               
               
                   
                   
                 tggaagctattcggataatttcttaaatattgatgaactt 
               
               
                   
                   
                 tggagtactgtttcttccttcaaactgaatgtaattaatt 
               
               
                   
                   
                 catgaataaatgcaccttatatgtttaaacaatctttgta 
               
               
                   
                   
                 tacttttgggatttttggtgcttatatgctaaatcacatt 
               
               
                   
                   
                 cagcatgtgtattttgacatttaaaatacttccctcaatt 
               
               
                   
                   
                 ctgtaaatt 
               
               
                   
               
               
                 12 
                 202110_at 
                 tcagctcacttcaagggtacctgaagcgaattgg 
               
               
                   
                   
                 caccaaagcagcagctgtattgccgcagttctag 
               
               
                   
                   
                 cttcaccttcacgatgtttcccttggtcaaaagc 
               
               
                   
                   
                 gcactaaatcgtctccaagttcgaagcattcagc 
               
               
                   
                   
                 aaacaatggcaaggcagagccaccagaaacgtac 
               
               
                   
                   
                 acctgattttcatgacaaatacggtaatgctgta 
               
               
                   
                   
                 ttagctagtggagccactttctgtattgttacat 
               
               
                   
                   
                 ggacatatgtagcaacacaagtcggaatagaatg 
               
               
                   
                   
                 gaacctgtcccctgttggcagagttaccccaaag 
               
               
                   
                   
                 gaatggaggaatcagtaatcatcccagctggtgt 
               
               
                   
                   
                 aataatgaattgtttaaaaaacagctcataattg 
               
               
                   
                   
                 atgccaaattaaagcactgtgtacccattaagat 
               
               
                   
                   
                 a 
               
               
                   
               
               
                 13 
                 202157_s_at 
                 tgtggcaaaaacgtttctttcttattttttttcttttcct 
               
               
                   
                   
                 aaaacagacttgaaagtattatacagggattggcattctt 
               
               
                   
                   
                 cccggtcactggtaacaatagcaatatgtgtccagggaca 
               
               
                   
                   
                 cagaatgttggtttctaacagactacttccaaaaacagtt 
               
               
                   
                   
                 tgagaaaaaaactgtctgattttaagtctctagaggtctg 
               
               
                   
                   
                 taatagtttttacatttttcaggcagtgtaaagttttttg 
               
               
                   
                   
                 ataaggccattttaggtggctcactttctcattaagatat 
               
               
                   
                   
                 atatatagaaccactttttgtagattagtataagaaaaat 
               
               
                   
                   
                 atttaccctgttttggggcaaatgctacctatttgtgtca 
               
               
                   
                   
                 ccttttgctgaactcacagttagacaatccatggtttaat 
               
               
                   
                   
                 gcacatgaaattacctatattttatactgtttcaatgtac 
               
               
                   
                   
                 aggagaaaggttactgtaaactgtgttatgttggtgcttc 
               
               
                   
                   
                 tgtgaattaagttgtggtttcatcatgagtc 
               
               
                   
               
               
                 14 
                 202233_s_at 
                 gctcgtgttgaatctagaaccgtagccagacatgggactg 
               
               
                   
                   
                 gaggacgagcaaaagatgcttaccgaatccggagatcctg 
               
               
                   
                   
                 aggaggaggaagaggaagaggaggaattagtggatcccct 
               
               
                   
                   
                 aacaacagtgagagagcaatgcgagcagttggagaaatgt 
               
               
                   
                   
                 gtaaaggcccgggagcggctagagctctgtgatgagcgtg 
               
               
                   
                   
                 attcctctcgatcacatacagaagaggattgcacggagga 
               
               
                   
                   
                 gctctttgacttcttgcatgcgagggaccattgcgtggcc 
               
               
                   
                   
                 cacaaactctttaacaacttgaaataaatgtgtggactta 
               
               
                   
                   
                 agttgcaccccagtcttcatcatctgggcatcagaatatt 
               
               
                   
                   
                 tccttatggttttggatgtaccatttgtttcttatttgtg 
               
               
                   
                   
                 taactgtaagttcacatcaacctcatgggtttggcttgag 
               
               
                   
                   
                 gctggtagcttctatgtaattcgcaatgattccatctaaa 
               
               
                   
               
               
                 15 
                 202378_s_at 
                 acatgtgcacatgcggcattttactatgaaatttaatatg 
               
               
                   
                   
                 ctgggttttttaatacctttatatatcatgttcactttaa 
               
               
                   
                   
                 gaaagacttcataagtaggagatgagttttattctcagca 
               
               
                   
                   
                 aatagacctgtcaaatttagattatgttactcaaattatg 
               
               
                   
                   
                 ttacttgtttggctgttcatgtagtcacggtgctctcaga 
               
               
                   
                   
                 aaatatattaacgcagtcttgtaggcagctgccaccttat 
               
               
                   
                   
                 gcagtgcatcgaaaccttttgcttggggatgtgcttggag 
               
               
                   
                   
                 aggcagataacgctgaagcaggcctctcatgacccaggaa 
               
               
                   
                   
                 ggccggggtggatccctctttgtgttgtagtccatgctat 
               
               
                   
                   
                 taaaagtgtggcccacagaccaagagcctcaacatttcct 
               
               
                   
                   
                 agagccttattagaaatgcagaatctgaagccccactctg 
               
               
                   
                   
                 gacccaggacattttgatgagatccaaaggagttgtatgc 
               
               
                   
                   
                 acatgaaagtttgagaagcatcatcatagagaagtaaaca 
               
               
                   
                   
                 tcacacccaacttccttatctttccagtggctaaac 
               
               
                   
               
               
                 16 
                 202664_at 
                 gaaatcagagcttacatgtgtgtttttttataacattttc 
               
               
                   
                   
                 agataaatgtattcaacatgtaatacagtattttnacatt 
               
               
                   
                   
                 cacctcttattttatattgaaatgtattacagtattaaaa 
               
               
                   
                   
                 ctcagtgttcagtatttatttcactatgcattttatttag 
               
               
                   
                   
                 taaaagccaggagaaatgtttaatccaatggtgccttact 
               
               
                   
                   
                 ttgtgatttaaaagaaatcaacttttttttatgtctaagt 
               
               
                   
                   
                 agtagattatttgcatatttgtaaaaactgttaggtcttt 
               
               
                   
                   
                 atattttaaagtgtaataccagttttgttattttagtagc 
               
               
                   
                   
                 agaaatgggatgattgttaaagttccccaaaaatgttggc 
               
               
                   
                   
                 atgaaattaatttttccctccttatagtcaaggaccgtag 
               
               
                   
                   
                 aggaagaaaaactttttttttcatatcatgcactatgtaaa 
               
               
                   
                   
                 cagacacattttgctatctgtgtcatcaggatagtgtaag 
               
               
                   
                   
                 tggtagggtagagactaccctagacatctgcatctttgta 
               
               
                   
                   
                 agttagcca 
               
               
                   
               
               
                 17 
                 202910_s_at 
                 ctgtggccacagcagctttgtacacgaagaccatccatcc 
               
               
                   
                   
                 tcccttcgtccaccactctactccctccaccctccctccc 
               
               
                   
                   
                 tgatcccgtgtgccaccaggagggagtggcagctatagtc 
               
               
                   
                   
                 tggcaccaaagtccaggacacccagtggggtggagtcgga 
               
               
                   
                   
                 gccactggtcctgctgctggctgcctctctgctccacctt 
               
               
                   
                   
                 gtgacccagggtggggacaggggctggcccagggctgcaa 
               
               
                   
                   
                 tgcagcatgttgccctggcacctgtggccagtactcggga 
               
               
                   
                   
                 cagactaagggcgcttgtcccatcctggacttttcctctc 
               
               
                   
                   
                 atgtctttgctgcagaactgaagagactaggcgctggggc 
               
               
                   
                   
                 tcagcttccctcttaagctaagactgatgtcagaggcccc 
               
               
                   
                   
                 atggcgaggccccttggggccactgcctgaggctcacggt 
               
               
                   
                   
                 acagaggcctgccctgcctggccgggcaggaggttctc 
               
               
                   
               
               
                 18 
                 202922_at 
                 aaaaatggcgttcttctcttgtggcctgttattc 
               
               
                   
                   
                 tgattgctgctgtatacagtttngtcactcttta 
               
               
                   
                   
                 gtttttagttaagcatactgatagactttcctct 
               
               
                   
                   
                 aaaagccattcactccagattttacctggggaat 
               
               
                   
                   
                 attctacatactgcttactttctctataaaactc 
               
               
                   
                   
                 atcaataaatcatgaaaggcactgagttttgtaa 
               
               
                   
                   
                 atcaggaccctaaatgtttaattgtaaataagtt 
               
               
                   
                   
                 tcagataattattatagctttgcgttgaagtttg 
               
               
                   
                   
                 ttgt 
               
               
                   
               
               
                 19 
                 202950_at 
                 taacatgttagttgtcatttggcatgagtgtgcattccag 
               
               
                   
                   
                 taattcttaattgatatttgattaattccatacctttgat 
               
               
                   
                   
                 taaaacatgctagttcaaaataagactgctcagtttccaa 
               
               
                   
                   
                 gggttttcaagcctacttacctttataaaggttctctagt 
               
               
                   
                   
                 ctctgattagccatgactgtattggactttgaacattttc 
               
               
                   
                   
                 tgaactaaaaacctctattctaaactaatctcatttggat 
               
               
                   
                   
                 gtgtaagtcttttgtaaaggcaagaataaataatatccag 
               
               
                   
                   
                 gacaatttattagttttctcagtattttcccaaatattag 
               
               
                   
                   
                 aatatttacttcattattggttggctgccaatgaccccat 
               
               
                   
                   
                 atgttctgtgagaatagtagctttatctttgatataatac 
               
               
                   
                   
                 atagtctccaaataggtaatacttcgcaattgattagatt 
               
               
                   
                   
                 ttcagagtagatttagagttatctgtttttctggtgaggg 
               
               
                   
                   
                 tcaaat 
               
               
                   
               
               
                 20 
                 203097_s_at 
                 tttccattaaattcagctgatcatattgatcagt 
               
               
                   
                   
                 agataaacgtaaatagcttcaaattttaaaagtg 
               
               
                   
                   
                 gaattgcagtgttttttcactgtatcaaacaatg 
               
               
                   
                   
                 tcagtgctttatttaataattctcttctgtatca 
               
               
                   
                   
                 tggcatttgtctacttgcttattacattgtcaat 
               
               
                   
                   
                 tatgcatttgtaattttacatgtaatatgcatta 
               
               
                   
                   
                 tttgccagttttattatataggctatggacctca 
               
               
                   
                   
                 tgtgcatatagaaagacagaaatctagctctacc 
               
               
                   
                   
                 acaagttgcacaaatgttatctaagcattaagta 
               
               
                   
                   
                 attgtagaacataggactgctaatctcagttcgc 
               
               
                   
                   
                 tctgtgatgtcaagtgcagaatgtacaattaact 
               
               
                   
                   
                 ggtgatttcctcatacttttgatactacttgtac 
               
               
                   
                   
                 ctgtatgtcttttagaaagacattggtggagtct 
               
               
                   
                   
                 gtatcccttttgtatttttaatacaataattgta 
               
               
                   
                   
                 catattggttatatttttgttgaagatggtagaa 
               
               
                   
                   
                 atgtactatgtttatgcttctacatccag 
               
               
                   
               
               
                 21 
                 203231_s_at 
                 tgcaccaggtgaaaacagggccagcagactccatggccca 
               
               
                   
                   
                 attcggtttcttcggtggtgatgtgaaaggagagaattac 
               
               
                   
                   
                 actttttttttttttaagtggcgtggaggcctttgcttcc 
               
               
                   
                   
                 acatttgtttttaacccagaatttctgaaatagagaattt 
               
               
                   
                   
                 aagaacacatcaagtaataaatatacagagaatatacttt 
               
               
                   
                   
                 tttataaagcacatgcatctgctattgtgttgggttggtt 
               
               
                   
                   
                 tcctctcttttccacggacagtgttgtgtttctggcatag 
               
               
                   
                   
                 ggaaactccaaacaacttgcacacctctactccggagctg 
               
               
                   
                   
                 agatttcttttacatagatgacctcgcttcaaatacgtta 
               
               
                   
                   
                 ccttactgatgataggatcttttcttgtagcactatacct 
               
               
                   
                   
                 tgtgggaatttttttttaaatgtacacctgatttgagaag 
               
               
                   
                   
                 ctga 
               
               
                   
               
               
                 22 
                 203300_x_at 
                 gaacttgttcagaccgttttagcacggaaaccta 
               
               
                   
                   
                 aaatgtgcagcttccttgagtggcgagatctgaa 
               
               
                   
                   
                 gattgtttacaaaagatatgctagtctgtatttt 
               
               
                   
                   
                 tgctgtgctattgaggatcaggacaatgaactaa 
               
               
                   
                   
                 ttaccctggaaataattcatcgttatgtggaatt 
               
               
                   
                   
                 acttgacaagtatttcggcagtgtctgtgaacta 
               
               
                   
                   
                 gatatcatctttaattttgagaaggcttatttta 
               
               
                   
                   
                 ttttggatgagtttcttttgggaggggaagttca 
               
               
                   
                   
                 ggaaacatccaagaaaaatgtccttaaagcaatt 
               
               
                   
                   
                 gagcaggctgatctactgcaggaggaagctgaaa 
               
               
                   
                   
                 ccccacgtagtgttcttgaagaaattggactgac 
               
               
                   
                   
                 ataactctcctcccttgttgatgacttcttgtgg 
               
               
                   
                   
                 catttcacacactgtagatggtcactcccttcat 
               
               
                   
                   
                 gtccatgttagctcatggtgtaagatgatgtctt 
               
               
                   
                   
                 gtcagtattactgttttgctaagccgcttcattc 
               
               
                   
                   
                 atgcctacacaatttt 
               
               
                   
               
               
                 23 
                 204160_s_at 
                 ttgtggttgttgagaggcattttcaaaccctgta 
               
               
                   
                   
                 taaataatccatgctgttggtcataagttaactg 
               
               
                   
                   
                 tattaagaacagtaaaataaataaaaaccaatag 
               
               
                   
                   
                 tactaatttngctttaaaaaaatttctaattttt 
               
               
                   
                   
                 ttcacataaaacaattatcctaaaggttaatagt 
               
               
                   
                   
                 tgatcgaaacagaataatagaaaaattctncttt 
               
               
                   
                   
                 aatttccattaaaaagcaaatagcattgacacat 
               
               
                   
                   
                 ttaaagcttttcatttaaagtagtggatgttttt 
               
               
                   
                   
                 gaagtatctaaaatagtagcagaatattttatac 
               
               
                   
                   
                 ttggtccttgcaatggtgtgagttttaatgattg 
               
               
                   
                   
                 cattatcgtgattggtggttatgagtttcagaaa 
               
               
                   
                   
                 tctatacttggcatccaactcatgagtggatttt 
               
               
                   
                   
                 atataggatggaacaggaaggtatgtcctgtcag 
               
               
                   
                   
                 tatcttaaccctttcaacaagacatttacctatt 
               
               
                   
                   
                 tgtctttccttacgttctcaaaatat 
               
               
                   
               
               
                 24 
                 204750_s_at 
                 gaccctcgcgatcttaatatttgccagtgatgcctgcaaa 
               
               
                   
                   
                 aatgtgacattacatgttccctccaaactagatgccgaga 
               
               
                   
                   
                 aacttgttggtagagttaacctgaaagagtgctttacagc 
               
               
                   
                   
                 tgcaaatctaattcattcaagtgatcctgacttccaaatt 
               
               
                   
                   
                 ttggaggatggttcagtctatacaacaaatactattctat 
               
               
                   
                   
                 tgtcctcggagaagagaagttttaccatattactttccaa 
               
               
                   
                   
                 cact 
               
               
                   
               
               
                 25 
                 204777_s_at 
                 ggaagtcttcataaagccgcagtagaacttgagc 
               
               
                   
                   
                 tgaaaacccagatggtgttaactggccgccccac 
               
               
                   
                   
                 tttccggcataactttttagaaaacagaaatgcc 
               
               
                   
                   
                 cttgatggtggaaaaaagaaaacaaccacccccc 
               
               
                   
                   
                 cactgcccaaaaaaaaaagccctgccctgttgct 
               
               
                   
                   
                 cgtgggtgctgtgtttactctcccgtgtgccttc 
               
               
                   
                   
                 gcgtccgggttgggagcttgctgtgtctaacctc 
               
               
                   
                   
                 caactgctgtgctgtctgctagggtcacctcctg 
               
               
                   
                   
                 tttgtgaaaggggaccttcttgttcgggggtggg 
               
               
                   
                   
                 aagtggcgaccgtgacctgagaaggaaagaaaga 
               
               
                   
                   
                 tcctctgctgacccctggagcagctctcgagaac 
               
               
                   
                   
                 tacctgttggtattgtccacaagctctcccgagc 
               
               
                   
                   
                 gccccatcttgtgccatgttttaagtcttcatgg 
               
               
                   
                   
                 atgttctgcatgtcatggggactaaaactcaccc 
               
               
                   
                   
                 aacagatctttccagaggtccatggtgg 
               
               
                   
               
               
                 26 
                 205042_at 
                 ttacatttgaactatatccttcctagtgggttagtgtgaa 
               
               
                   
                   
                 aaagagtttggctgattcctaaaactctgccagccctgca 
               
               
                   
                   
                 gtaatctccaggcctggttattgttcagacattccatggt 
               
               
                   
                   
                 gattcctgggaaggaagcttggctgctcagtttctgagtc 
               
               
                   
                   
                 tggggtgagataatgttctggaaggacatctgttctttgg 
               
               
                   
                   
                 tgtaatctctcatggtgaaatctgctctgtacatcagaca 
               
               
                   
                   
                 attgcattgctaccaagtttcataccaa 
               
               
                   
               
               
                 27 
                 205114_s_at 
                 gattccacagaatttcatagctgactactttgagacgagc 
               
               
                   
                   
                 agccagtgctccaagcccggtgtcatcttcctaaccaagc 
               
               
                   
                   
                 gaagccggcaggtctgtgctgaccccagtgaggagtgggt 
               
               
                   
                   
                 ccagaaatatgtcagcgacctagagctgagtgcctgaggg 
               
               
                   
                   
                 gtccagaagcttcgaggcccagcgacctcggtgggccagt 
               
               
                   
                   
                 ggggaggagcaggagcctgagccttgggaaacatgcgtgt 
               
               
                   
                   
                 gacctccacagctacctcttctatggactggttgttgcca 
               
               
                   
                   
                 aacagccacactgtgggactcttcttaacttaaattttaa 
               
               
                   
                   
                 tttatttatactatttagtttttgtaatttattttcgatt 
               
               
                   
                   
                 tcacagtgtgtttgtgattgtttgctctgagagttcccct 
               
               
                   
                   
                 gtcccctcccccttccctcacaccgcgtctggtgacaacc 
               
               
                   
                   
                 gagtggctgtcatcagcctgtgtaggcagtcatggcacca 
               
               
                   
                   
                 aagccaccagactgacaaatgtgtatc 
               
               
                   
               
               
                 28 
                 205624_at 
                 tatgaaacccgctacatctatggcccaatagaatcaacaa 
               
               
                   
                   
                 tttacccgatatcaggttcttctttagactgggcttatga 
               
               
                   
                   
                 cctgggcatcaaacacacatttgcctttgagctccgagat 
               
               
                   
                   
                 aaaggcaaatttggttttctccttccagaatcccggataa 
               
               
                   
                   
                 agccaacgtgcagagagaccatgctagctgtcaaatttat 
               
               
                   
                   
                 tgccaagtatatcctcaagcatacttcctaaagaactgcc 
               
               
                   
                   
                 ctctgtttggaataagccaattaatccttttttgtgcctt 
               
               
                   
                   
                 tcatcagaaagtcaatcttcagttatccccaaatgcagct 
               
               
                   
                   
                 tctatttcacctgaatccttctcttgctcatttaagtccc 
               
               
                   
                   
                 atgttactgctgtttgcttttacttactttcagtagcacc 
               
               
                   
                   
                 ataacgaagtagctttaagtgaaaccttttaactaccttt 
               
               
                   
                   
                 ctttgctccaagtgaagtttggacccagcagaaagcatta 
               
               
                   
                   
                 ttttgaaaggtgatatacagtggggcacagaaaacaaatg 
               
               
                   
                   
                 aaaaccctcagtttctcacagattttcaccatgtggcttc 
               
               
                   
                   
                 atcaa 
               
               
                   
               
               
                 29 
                 206207_at 
                 aggagacaacaatgtccctgctacccgtgccatacacaga 
               
               
                   
                   
                 ggctgcctctttgtctactggttctactgtgacaatcaaa 
               
               
                   
                   
                 gggcgaccacttgtctgtttcttgaatgaaccatatctgc 
               
               
                   
                   
                 aggtggatttccacactgagatgaaggaggaatcagacat 
               
               
                   
                   
                 tgtcttccatttccaagtgtgctttggtcgtcgtgtggtc 
               
               
                   
                   
                 atgaacagccgtgagtatggggcctggaagcagcaggtgg 
               
               
                   
                   
                 aatccaagaacatgccctttcaggatggccaagaatttga 
               
               
                   
                   
                 actgagcatctcagtgctgccagataagtaccaggtaatg 
               
               
                   
                   
                 gtcaatggccaatcctcttacacctttgaccatagaatca 
               
               
                   
                   
                 agcctgaggctgtgaagatggtgcaagtgtggagagatat 
               
               
                   
                   
                 ctccctgaccaaatttaatgtcagctatttaaagagataa 
               
               
                   
                   
                 ccagacttcatgttgccaaggaatccctgtctctacgtga 
               
               
                   
                   
                 acttgggattcca 
               
               
                   
               
               
                 30 
                 206790_s_at 
                 gaacttacttcagattgtgcgggaccactgggttcatgtt 
               
               
                   
                   
                 cttgtccctatgggatttgtcattggatgttatttagaca 
               
               
                   
                   
                 gaaagagtgatgaacggctaactgccttccggaacaagag 
               
               
                   
                   
                 tatgttatttaaaagggaattgcaacccagtgaagaagtt 
               
               
                   
                   
                 acctggaagtaaagactggctagattatcgaatgttcaca 
               
               
                   
                   
                 ttttaaagttctgagaga 
               
               
                   
               
               
                 31 
                 207008_at 
                 acctaacgaagtatccttcagcctgaaagaggaatgaagt 
               
               
                   
                   
                 actcatacatgttacaacacggacgaaccttgaaaacttt 
               
               
                   
                   
                 atgctaagtgaaataagccagacatcaacagataaatagt 
               
               
                   
                   
                 ttatgattccacctacatgaggtactgagagtgaacaaat 
               
               
                   
                   
                 ttacagagacagaaagcagaacagtgattaccagggactg 
               
               
                   
                   
                 aggggaggggagcatgggaagtgacggtttaatgggcaca 
               
               
                   
                   
                 gggtttatgtttaggatgttgaaaaagttctgcagataaa 
               
               
                   
                   
                 cagtagtgatagttgtaccgcaatgtgacttaatgccact 
               
               
                   
                   
                 aaattgacacttaaaaatggtttaaatggtcaattttgtt 
               
               
                   
                   
                 atgtatattttatatcaatttaaaaaaaaacctgagcccc 
               
               
                   
                   
                 aaaaggtattttaatcaccaaggctgattaaaccaaggct 
               
               
                   
                   
                 agaaccacctgcc 
               
               
                   
               
               
                 32 
                 207815_at 
                 caagccctgctgtacaagaaaatcattaaggaacatttgg 
               
               
                   
                   
                 agagttagctactagctgcctaagtgtgcactttcaatct 
               
               
                   
                   
                 aactgtgaaagaatcttctgatgtttgtattatccttctt 
               
               
                   
                   
                 atattatattaacaaaataaatcaagttgtggtatagtca 
               
               
                   
                   
                 atctatttcttaataatactgcaaaaataatgctgacaca 
               
               
                   
                   
                 tcacaatttcatattttaaaatttccagaattttaagcaa 
               
               
                   
                   
                 aaagcattatgaaggaaggcttggtttaataaagactgat 
               
               
                   
                   
                 tttgttcagtgttatatgttagctgatacatatttgttca 
               
               
                   
                   
                 tttatgtgattgcagtactttatagctacatatttacctt 
               
               
                   
                   
                 gaatgttacaattagcttgccaata 
               
               
                   
               
               
                 33 
                 208051_s_at 
                 gaactcccagctaaacaaccaagacttcactgaagattta 
               
               
                   
                   
                 ttccaattctagaattgttctttttttattttttattttt 
               
               
                   
                   
                 tcaactgactaacttcattaccttaaagcctagaacatta 
               
               
                   
                   
                 ttctgctttatttatatggctttctcaattttattttgta 
               
               
                   
                   
                 gcatgggttgaatcgaactttttactagagaattttacta 
               
               
                   
                   
                 gatatttgtcattcaagttttcatctgctttataattgat 
               
               
                   
                   
                 acaccttgagggtcacttttctaatacttttacctataat 
               
               
                   
                   
                 gtggtacccacctcagcccctaataaataatatttttacc 
               
               
                   
                   
                 ctaatgtcaaatctttttcccaggctaactaaaaactgtg 
               
               
                   
                   
                 tacaaaaggattgcttgtaaatatgcatgtaaatagttct 
               
               
                   
                   
                 gttaataacccactgttttacatttggtacatctgtgtct 
               
               
                   
                   
                 gctaatacagttagctttctcacttttctgcttgtttgtt 
               
               
                   
                   
                 cagtctgaatt 
               
               
                   
               
               
                 34 
                 208161_s_at 
                 gatagcaaacactgggggcaccttaagattttgcacctgt 
               
               
                   
                   
                 aaagtgccttacagggtaactgtgctgaatgctttagatg 
               
               
                   
                   
                 aggaaatgatccccaagtggtgaatgacacgcctaaggtc 
               
               
                   
                   
                 acagctagtttgagccagttagactagtcccccggtctcc 
               
               
                   
                   
                 cgattcccaactgagtgttatttgcacactgcactgtttt 
               
               
                   
                   
                 caaataacgattttatgaaatgacctctgtcctccctctg 
               
               
                   
                   
                 atttttcatattttcctaaagtttcgtttctgttttttaa 
               
               
                   
                   
                 taaaaagctttttcctcctggaacagaagacagctgctgg 
               
               
                   
                   
                 gtcaggccacccctaggaactcagtcctgtactctggggt 
               
               
                   
                   
                 gctgcctgaatccattaaaaat 
               
               
                   
               
               
                 35 
                 208637_x_at 
                 ggtcccgaggagttcaaagcctgcctcatcagcttgggtt 
               
               
                   
                   
                 atgatattggcaacgacccccagggagaagcagaatttgc 
               
               
                   
                   
                 ccgcatcatgagcattgtggaccccaaccgcctgggggta 
               
               
                   
                   
                 gtgacattccaggccttcattgacttcatgtcccgcgaga 
               
               
                   
                   
                 cagccgacacagatacagcagaccaagtcatggcttcctt 
               
               
                   
                   
                 caagatcctggctggggacaagaactacattaccatggac 
               
               
                   
                   
                 gagctgcgccgcgagctgccacccgaccaggctgagtact 
               
               
                   
                   
                 gcatcgcgcggatggccccctacaccggccccgactccgt 
               
               
                   
                   
                 gccaggtgctctggactacatgtccttctccacggcgctg 
               
               
                   
                   
                 tacggcgagagtgacctctaatccaccccgcccggccgcc 
               
               
                   
                   
                 ctcgtcttgtgcgccgtgccctgccttgcacctccgccgt 
               
               
                   
                   
                 cgcccatctcctgcctgggttcggtttcagctcccagcct 
               
               
                   
                   
                 ccacccgggtgagctggggcccacgtggcatcgatcctcc 
               
               
                   
                   
                 ctgcccgcgaagtgacagtttac 
               
               
                   
               
               
                 36 
                 208918_s_at 
                 gaaatgggctgggagtgcttctgtcctgctgacaccccgc 
               
               
                   
                   
                 ggtgggtccctggagcgcggcctccagctgccgcaatttc 
               
               
                   
                   
                 catgccaggatatttttccgcaaatcagtcggttgaaatt 
               
               
                   
                   
                 cagaggagtcagaatgactcgacctgtccttcaatgttga 
               
               
                   
                   
                 taata 
               
               
                   
               
               
                 37 
                 208982_at 
                 attgcttgctaaagaagtggtctcctgaggtcttaagaca 
               
               
                   
                   
                 ttcctgacagtgtcttgagtgggtgggagagaggntgctg 
               
               
                   
                   
                 tcattgcgctgtggaatttcacagatgagaaccacgccta 
               
               
                   
                   
                 gccaaaatcacttttcctgtttgcctcagtgacacagctg 
               
               
                   
                   
                 cagggaccctcgtggatgttgtattaaat 
               
               
                   
               
               
                 38 
                 209009_at 
                 gagcttccccaactcataaatgccaattttccagtggatc 
               
               
                   
                   
                 cccaaaggatgtctatttttggccactccatgggaggtca 
               
               
                   
                   
                 tggagctctgatctgtgctttgaaaaatcctggaaaatac 
               
               
                   
                   
                 aaatctgtgtcagcatttgctccaatttgcaaccctgtac 
               
               
                   
                   
                 tctgtccctggggcaaaaaagcctttagtggatatttggg 
               
               
                   
                   
                 aacagatcaaagtaaatggaaggcttatgatgctacccac 
               
               
                   
                   
                 cttgtgaaatcctatccaggatctcagctggacatactaa 
               
               
                   
                   
                 ttgatcaagggaaagatgaccagtttcttttagatggaca 
               
               
                   
                   
                 gttactccctgataacttcatagctgcctgtacag 
               
               
                   
               
               
                 39 
                 209020_at 
                 caggggcagtcgttgagcctttgagaacttctgttccaag 
               
               
                   
                   
                 gctcccatcagagagtaagaaggaagactcctctgacgct 
               
               
                   
                   
                 acccaagtcccccaagcaagtctcaaagccagtgatctct 
               
               
                   
                   
                 ctgactttcaatcagtttccaagctaaaccaggggcaagc 
               
               
                   
                   
                 catgcacatgcataggcaaggaatgccagtgtaagagatg 
               
               
                   
                   
                 gcatgatatggaagtgtattccttttcaggcctgcagagt 
               
               
                   
                   
                 gtccctcccttggctccagaacgaagatccacacttgagg 
               
               
                   
                   
                 actactctcagtcgctgcacgccagaactctgtctggctc 
               
               
                   
                   
                 tccccgatcctgttctgagcaagctcgagtcttcgtggat 
               
               
                   
                   
                 gatgtgaccattgaggacctgtcaggctacatggagtatt 
               
               
                   
                   
                 acttgtatattcccaagaaaatgtcccacatgggcagaaa 
               
               
                   
                   
                 tgatgtacacctgatagcaagaagctaattcatatgcttt 
               
               
                   
                   
                 aaaccaatgaaggcttgtcaaagagatttagttaatggca 
               
               
                   
                   
                 gaccttgtggccactttgtgtgagaagacatctctttctg 
               
               
                   
                   
                 ctca 
               
               
                   
               
               
                 40 
                 209146_at 
                 gaacctcatcaattgatagcagtgagtgactgaagcttcc 
               
               
                   
                   
                 aaatcaagaaaagccggcaccaagaacttccattctaatc 
               
               
                   
                   
                 tagagctgaccagtttgagctgattctctctttgaagagt 
               
               
                   
                   
                 ccttcttgattgcagtgcagtactggcatttctgaatgga 
               
               
                   
                   
                 tgtaagtggagtattttagtctaaaggcttttcaaattac 
               
               
                   
                   
                 ttgaatttttttaaaaattgaggagctttatttctattta 
               
               
                   
                   
                 cccttccatttttgtatatcaaatttccattgtcattaaa 
               
               
                   
                   
                 aactgtatcttgaaactttgtgaactgacttgctgtattt 
               
               
                   
                   
                 gcactttgagctcttgaaa 
               
               
                   
               
               
                 41 
                 209193_at 
                 gattgtagtggatctaatttttcagaaattttgcctttaa 
               
               
                   
                   
                 gttattttacctgtttttgtttcttgttttgaaagatgcg 
               
               
                   
                   
                 cattctaacctggaggtcaatgttatgtatttatttattt 
               
               
                   
                   
                 atttatttggttcccttcctattccaagcttccatagctg 
               
               
                   
                   
                 ctgccctagttttctttcctcctttcctcctctgacttgg 
               
               
                   
                   
                 ggaccttttgggggagggctgcgacgcttgctctgtttgt 
               
               
                   
                   
                 ggggtgacgggactcaggcgggacagtgctgcagctccct 
               
               
                   
                   
                 ggcttctgtggggcccctcacctacttacccaggtgggtc 
               
               
                   
                   
                 ccggctctgtgggtgatggggaggggcattgctgactgtg 
               
               
                   
                   
                 tatataggataattatgaaaagcagttctggatggtgtgc 
               
               
                   
                   
                 cttccagatcctctctggggctgtgttttgagcagcaggt 
               
               
                   
                   
                 agcctggctggttttatctgagtga 
               
               
                   
               
               
                 42 
                 209710_at 
                 gatcccacagccctagtatgaaagctgggggtgg 
               
               
                   
                   
                 ggaggggcctttgctgcccttggtttctgggggc 
               
               
                   
                   
                 tggttggcatttgctggcctggcagggggtgaag 
               
               
                   
                   
                 gcaggagttgggggcaggtcaggaccaggaccca 
               
               
                   
                   
                 gggagaggctgtgtccctgctggggtctcaggtc 
               
               
                   
                   
                 cagctttactgtggctgtctggatccttcccaag 
               
               
                   
                   
                 gtacagctgtatataaacgtgtcccgagcttaga 
               
               
                   
                   
                 ttctgtatgcggtgacggcggggtgtggtggcct 
               
               
                   
                   
                 gtgaggggcccctggcccaggaggaggattgtgc 
               
               
                   
                   
                 tgatgtagtgaccaagtgcaatatgggcgggcag 
               
               
                   
                   
                 tcgctgcagggagcaccacggccagaagtaactt 
               
               
                   
                   
                 attttgtactagtgtccgcataagaaaaagaatc 
               
               
                   
                   
                 ggcagtattttctgtttttatgttttatttggct 
               
               
                   
                   
                 tgttttattttggattagtgaactaagttattgt 
               
               
                   
                   
                 taattatgtacaacatttatatattgtctgtaaa 
               
               
                   
                   
                 aaatgtatgctatcctcttattcct 
               
               
                   
               
               
                 43 
                 210042_s_at 
                 gaaatctacgcaaatggtcccatcagctgtggaataatgg 
               
               
                   
                   
                 caacagaaagactggcaaactacaccggaggcatctatgc 
               
               
                   
                   
                 cgaataccaggacaccacatatataaaccatgtcgtttcc 
               
               
                   
                   
                 gtggctgggtggggcatcagtgatgggactgagtactgga 
               
               
                   
                   
                 ttgtccggaattcatggggtgaaccatggggcgagagagg 
               
               
                   
                   
                 ctggctgaggatcgtgaccagcacctataaggatgggaag 
               
               
                   
                   
                 ggcgccagatacaaccttgccatcgaggagcactgtacat 
               
               
                   
                   
                 ttggggaccccatcgtttaaggccatgtcactagaagcgc 
               
               
                   
                   
                 agtttaagaaaaggcatggtgacccatgaccagaggggat 
               
               
                   
                   
                 cctatggttatgtgtgccaggctggctggcaggaactggg 
               
               
                   
                   
                 gtggctatcaatattggatggcgaggacagcgtggtactg 
               
               
                   
                   
                 gctgcgagtgttcctgagagttgaaagtgggatgacttat 
               
               
                   
                   
                 gacacttgcacagcatggctctgcctcacaatgatgcagt 
               
               
                   
                   
                 cagccac 
               
               
                   
               
               
                 44 
                 210184_at 
                 cagttctgaatatgctgctcatccccacctgtct 
               
               
                   
                   
                 tcaacagctccccattaccctcaggacaatgtct 
               
               
                   
                   
                 gaactctccagcttcgcgtgagaagtccccttcc 
               
               
                   
                   
                 atcccagagggtgggcttcagggcgcacagcatg 
               
               
                   
                   
                 agagcctctgtgcccccatcaccctcgtttccag 
               
               
                   
                   
                 tgaattagtgtcatgtcagcatcagctcagggct 
               
               
                   
                   
                 tcatcgtggggctctcagttccgattccccaggc 
               
               
                   
                   
                 tgaattgggagtgagatgcctgcatgctgggttc 
               
               
                   
                   
                 tgcacagctggcctcccgcggttgggtcaacatt 
               
               
                   
                   
                 gctggcctggaagggaggagcgccctctagggag 
               
               
                   
                   
                 ggacatggccccggtgcggctgcagctcaccagc 
               
               
                   
                   
                 cccaggggcagaagagacccaaccacttcctatt 
               
               
                   
                   
                 ttttgaggctatgaatatagtacctgaaaaaatg 
               
               
                   
                   
                 ccaagcactagattatttttttaaaaagcgtact 
               
               
                   
                   
                 ttaaatgtttgtgttaatacacattaaaacatcg 
               
               
                   
                   
                 cacaaaaacgatgcatctaccgctcc 
               
               
                   
               
               
                 45 
                 210732_s_at 
                 cccagcttcctagtaatagaggaggagacatttctaaaat 
               
               
                   
                   
                 cgcacccagaactgtctacaccaagagcaaagattcgact 
               
               
                   
                   
                 gtcaatcacactttgacttgcaccaaaataccacctatga 
               
               
                   
                   
                 actatgtgtcaa 
               
               
                   
               
               
                 46 
                 210895_s_at 
                 gtgtacataaatttgacctgctcatctatacacggttacc 
               
               
                   
                   
                 cagaacctaagaagatgagtgttttgctaagaaccaagaa 
               
               
                   
                   
                 ttcaactatcgagtatgatggtattatgcagaaatctcaa 
               
               
                   
                   
                 gataatgtcacagaactgtacgacgtttccatcagcttgt 
               
               
                   
                   
                 ctgtttcattccctgatgttacgagcaatatgaccatctt 
               
               
                   
                   
                 ctgtattctggaaactgacaagacgcggcttttatcttca 
               
               
                   
                   
                 cctttctctatagagcttgaggaccctcagcctcccccag 
               
               
                   
                   
                 accacattccttggattacagctgtacttccaacagttat 
               
               
                   
                   
                 tatatgtgtgatggttttctgtctaattctatggaaatgg 
               
               
                   
                   
                 aagaagaagaagcggcctcgcaactcttataaatgtgg 
               
               
                   
               
               
                 47 
                 211506_s_at 
                 gtgtgaaggtgcagttttgccaaggagtgctaaa 
               
               
                   
                   
                 gaacttagatgtcagtgcataaagacatactcca 
               
               
                   
                   
                 aacctttccaccccaaatttatcaaagaactgag 
               
               
                   
                   
                 agtgattgagagtggaccacactgcgccaacaca 
               
               
                   
                   
                 gaaattattgtaaagctttctgatggaagagagc 
               
               
                   
                   
                 tctgtctggaccccaaggaaaactgggtgcagag 
               
               
                   
                   
                 ggttgtggagaa 
               
               
                   
               
               
                 48 
                 211734_s_at 
                 acatctccattacaaatgccacagttgaagacag 
               
               
                   
                   
                 tggaacctactactgtacgggcaaagtgtggcag 
               
               
                   
                   
                 ctggactatgagtctgagcccctcaacattactg 
               
               
                   
                   
                 taataaaagctccgcgtgagaagtactggctaca 
               
               
                   
                   
                 attttttatcccattgttggtggtgattctgttt 
               
               
                   
                   
                 gctgtggacacaggattatttatctcaactcagc 
               
               
                   
                   
                 agcaggtcacatttctcttgaagattaagagaac 
               
               
                   
                   
                 caggaaaggcttcagacttctgaacccacatcct 
               
               
                   
                   
                 aagccaaaccccaaaaacaactgatataattact 
               
               
                   
                   
                 caagaaatatttgcaacattagtttttttccagc 
               
               
                   
                   
                 atcagcaattactactcaattgtcaaacacagct 
               
               
                   
                   
                 tgca 
               
               
                   
               
               
                 49 
                 211995_x_at 
                 agtactcggtgtggatcggtggctccatcctggcctcact 
               
               
                   
                   
                 gtccaccttccagcagatgtggattagcaagcaggagtac 
               
               
                   
                   
                 gacgagtcgggcccctccatcgtccaccgcaaatgcttct 
               
               
                   
                   
                 aaacggactcagcagatgcgtagcatttgctgcatgggtt 
               
               
                   
                   
                 aattgagaatagaaatttgcccctggcaaatgcacacacc 
               
               
                   
                   
                 tcatgctagcctcacgaaactggaataagccttcgaaaag 
               
               
                   
                   
                 aaattgtccttgaagcttgtatctgatatcagcactggat 
               
               
                   
                   
                 tgtagaacttgttgctgattttgaccttgtattgaagtta 
               
               
                   
                   
                 actgttccccttggtatttgtttaataccctgtacatatc 
               
               
                   
                   
                 tttgagttcaacctttagtacgtgtggcttggtcacttcg 
               
               
                   
                   
                 tggctaaggtaagaacgtgcttgtggaagacaagtctgtg 
               
               
                   
                   
                 gcttggtgagtctgtgtggccagcagcctctgatctgtgc 
               
               
                   
                   
                 agggtattaacgtgtcagggctgagtgttctgggatttct 
               
               
                   
                   
                 ctagaggct 
               
               
                   
               
               
                 50 
                 212314_at 
                 tattttggtacctgtgcttgccacagccctgttcctcaaa 
               
               
                   
                   
                 gctgaattgatagatttctctttgacttccaagacctagc 
               
               
                   
                   
                 agttataaggcaccttgaaataaattgtttgtgcctggaa 
               
               
                   
                   
                 atgcagggagggcaatagctttgtaaattggtttacattt 
               
               
                   
                   
                 ttctccttgaatttttctagggtcctagtgcttccgaatc 
               
               
                   
                   
                 atttaatggcattgtcggatatcttttacatttcaattgc 
               
               
                   
                   
                 aatccatgaaattacatttagaagattcttagtacttaac 
               
               
                   
                   
                 tgtagtcttctccatgaattacacgttagaatagactggc 
               
               
                   
                   
                 agcaacngaatatgcagcaagtaagcctctagcttatagt 
               
               
                   
                   
                 ttcatccctacccctcatgcctgcgtgagtctgtacaggg 
               
               
                   
                   
                 atatgtgtgtgtgtgtgtgtgtgtgtgtgttagagaggaa 
               
               
                   
                   
                 gaggaagagcagaatgtctgtatactacatgctgctaagg 
               
               
                   
                   
                 tagtgaataaatcagtaatgcaatattgtgggtccaaact 
               
               
                   
                   
                 actctttgcactact 
               
               
                   
               
               
                 51 
                 212335_at 
                 accacgcttggctaagaacacctaaatttttatg 
               
               
                   
                   
                 tttcttggctcaaaaaccagttccatttctaatg 
               
               
                   
                   
                 ttgtcctcacaagaaggctaattggtggtgagac 
               
               
                   
                   
                 agcaggggaggaggaagagctgtggtttgtaact 
               
               
                   
                   
                 tgttcaactcaggcaataagcgattttagcttta 
               
               
                   
                   
                 tttaaagtcttctgtccagctttaagcactttgt 
               
               
                   
                   
                 aagacatggctgaaagtagcttttctatcagaat 
               
               
                   
                   
                 tgcagatagtcatgttgggctaacagtcaattgg 
               
               
                   
                   
                 atatattcctttacctcacatgaccccagcaact 
               
               
                   
                   
                 gtggtggtatctagaggtgaaacaggcaagtgaa 
               
               
                   
                   
                 atggacacctctgctgtgaatgttttagagaagg 
               
               
                   
                   
                 aaattcaaaaaatgttgtaactgaaagcactgtt 
               
               
                   
                   
                 gaatatgggtatcggctttctttttcactttgac 
               
               
                   
                   
                 tcttaacattatcagtcaacttccacattaatg 
               
               
                   
               
               
                 52 
                 212386_at 
                 gagatttaccatgtatcagtgcctggctttttgt 
               
               
                   
                   
                 tataaagctttgtttgtctagtgctcttttgcta 
               
               
                   
                   
                 taaaatagactgtagtacaccctagtaggaaaaa 
               
               
                   
                   
                 aaaaaaactaaatttaaaaataaaaaatatattt 
               
               
                   
                   
                 ggcttatttttcgcaggagcaatccttttatacc 
               
               
                   
                   
                 atgaatatt 
               
               
                   
               
               
                 53 
                 212671_s_at 
                 accaatgaggttcctgaggtcacagtgttttccaagtctc 
               
               
                   
                   
                 ccgtgacactgggtcagcccaacaccctcatctgtcttgt 
               
               
                   
                   
                 ggacaacatctttcctcctgtggtcaacatcacntggctg 
               
               
                   
                   
                 agcaatgggcactcagtcacagaaggtgtttctgagacca 
               
               
                   
                   
                 gcttcctctccaagagtgatcattccttcttcaagatcag 
               
               
                   
                   
                 ttacctcaccttcctcccttctgntgatgagatttatgac 
               
               
                   
                   
                 tgcaaggtggagcactggggcctggatgagcctcttctga 
               
               
                   
                   
                 aacactgggagcctg 
               
               
                   
               
               
                 54 
                 212897_at 
                 aaggagacctttgaagctttttgagggcaaactttacctt 
               
               
                   
                   
                 tgtggtccccaaatgatggcatttctctttgaaatttatt 
               
               
                   
                   
                 agatactgttatgtcccccaagggtacaggaggggcatcc 
               
               
                   
                   
                 ctcagcctatgggnaacacccaaactaggaggggttattg 
               
               
                   
                   
                 acaggaaggaatgaatccaagtgaaggctttctgctcttc 
               
               
                   
                   
                 gtgttacaaaccagtttcagagttagctttctggggaggt 
               
               
                   
                   
                 gtgtgtttgtgaaaggaattcaagtgttgcaggacagatg 
               
               
                   
                   
                 agctcaaggtaaggtagctttggcagcagggctgatacta 
               
               
                   
                   
                 tgaggctgaaacaatccttgtgatgaagtagatcatgcag 
               
               
                   
                   
                 tgacatacaaagaccaaggattatgtatatttttatatct 
               
               
                   
                   
                 ctgtggttttgaaactttagtacttagaattttggccttc 
               
               
                   
                   
                 tgcactactcttttgctcttacgaacataatggactctta 
               
               
                   
                   
                 agaatggaaagggatgacatttacctatgtgtgctgcctc 
               
               
                   
                   
                 attcctggtgaagcaactgctacttgttctctatgcctct 
               
               
                   
                   
                 aaaat 
               
               
                   
               
               
                 55 
                 212999_x_at 
                 cactgcagaatgaaggaacatcccttgaggtgac 
               
               
                   
                   
                 ccagccaacctgtggccagaaggaggnttgtacc 
               
               
                   
                   
                 ttgaaaagacactgaaagcattttggngtgtnaa 
               
               
                   
                   
                 gtaagggtgggcagaggaggtagaaaatcaattc 
               
               
                   
                   
                 aattgtcgcatcattcatggttctttaatattga 
               
               
                   
                   
                 tgctcagtgcantggcctnagaatatcccagcct 
               
               
                   
                   
                 ctcttctggtttgntgagtgctntntaagtaagc 
               
               
                   
                   
                 atggtngaattgtttggggncanatatagtganc 
               
               
                   
                   
                 cttggtcactggtgtttcaaacattctggnaagt 
               
               
                   
                   
                 cacatcnatcaagaatantttttanttttaagaa 
               
               
                   
                   
                 agcataaccagcaataaa 
               
               
                   
               
               
                 56 
                 213309_at 
                 gtatgtagcaatcctgcgtgtgaaggcaaataaactcttt 
               
               
                   
                   
                 aacaggcaattatattgctggccaaaatatgctatatttg 
               
               
                   
                   
                 tatacaaagacattctaactcagttccagtatgaagaaag 
               
               
                   
                   
                 attattcactctagctccactgagaaacattttcctaagt 
               
               
                   
                   
                 gaaaacaatttcttaagatggaaatggattggattgtcaa 
               
               
                   
                   
                 attattatttattggagaaaaaaacctgatctacacattt 
               
               
                   
                   
                 ttacttatatggggttgccagagtctctgggttctagatg 
               
               
                   
                   
                 attttggtggcatgcttgctgagccataattactaaagag 
               
               
                   
                   
                 aatgtaagtggacgggttccctgaatccccggggtccttg 
               
               
                   
                   
                 gagagccatcgaggagaatgtgcaattggactgaagctcc 
               
               
                   
                   
                 ctggctgaagatacatgccgagtcagcacatgggtagaga 
               
               
                   
                   
                 t 
               
               
                   
               
               
                 57 
                 213506_at 
                 gcacacagagatttgagaaccattgttctgaatgctgctt 
               
               
                   
                   
                 ccatttgacaaagtgccgtgataatttttgaaaagagaag 
               
               
                   
                   
                 caaacaatggtgtctcttttatgttcagcttataatgaaa 
               
               
                   
                   
                 tctgtttgttgacttattaggactttgaattatttcttta 
               
               
                   
                   
                 ttaaccctctgagttttngtatgtattattattaaagaaa 
               
               
                   
                   
                 aatgcaatcaggattttaaacatgtaaatacaaattttgt 
               
               
                   
                   
                 ataacttttgatgacttcagtgaaattttcaggtagtctg 
               
               
                   
                   
                 agtaatagattgttttgccacttagaatagcatttgccac 
               
               
                   
                   
                 ttagtattttaaaaaataattgttggagtatttattgtca 
               
               
                   
                   
                 gttttgttcacttgttatctaatacaaaattataaagcct 
               
               
                   
                   
                 tcagagggtttggaccacatctctttggaaa 
               
               
                   
               
               
                 58 
                 213883_s_at 
                 agagaacttctagtgtatggatttaaagatttctcttttt 
               
               
                   
                   
                 cattcatataccattttatgagttctgtataattttttgt 
               
               
                   
                   
                 ggtttttgttttgttgagttaaagtatattattgtgagat 
               
               
                   
                   
                 ttatttaataggacttcctttgaaagctgtataatagtgt 
               
               
                   
                   
                 ttctcgggcttctgtctctatgagagatagcttattactc 
               
               
                   
                   
                 tgatactctttaatcttttacaaaggcaagttgccacttg 
               
               
                   
                   
                 tcatttttgtt 
               
               
                   
               
               
                 59 
                 214305_s_at 
                 gttctgacccctggaaagacaccaattggcacaccagcca 
               
               
                   
                   
                 tgaacatggctacccctactccaggtcacataatgagtat 
               
               
                   
                   
                 gactcctgaacagcttcaggcttggcggtgggaaagagaa 
               
               
                   
                   
                 attgatgagagaaatcgcccactttctgatgaggaattag 
               
               
                   
                   
                 atgctatgttcccagaaggatataaggtacttcctcctcc 
               
               
                   
                   
                 agctaattatgttcctattcgaactccagctcgaaagctg 
               
               
                   
                   
                 acagctactccaacacctttgggtggtatgactggtttcc 
               
               
                   
                   
                 acatgcaaactgaagatcgaactatgaaaagtgttaatga 
               
               
                   
                   
                 ccagccatctgg 
               
               
                   
               
               
                 60 
                 214512_s_at 
                 gaccaagagggtgttcgactgctagagccgancgaagcga 
               
               
                   
                   
                 tgcctaaatcaaaggaacttgtttcttcaagctcttctgg 
               
               
                   
                   
                 cagtgattctgacagtgaggttgacaaaaagttaaagagg 
               
               
                   
                   
                 aaaaagcaagttgctccagaaaaacctgtaaagaaacaaa 
               
               
                   
                   
                 agacaggtgagacttcgagagccctgtcatcttctaaaca 
               
               
                   
                   
                 gagcagcagcagcagagatgataacatgtttcagattggg 
               
               
                   
                   
                 a 
               
               
                   
               
               
                 61 
                 214807_at 
                 tcttcattccacgagaattttgatttttaacagcagtctc 
               
               
                   
                   
                 tctttttctcagcattgcaaatatatatgtatatatacat 
               
               
                   
                   
                 tcatgaccaaagtatcgcttactgaccatgcagctgtaaa 
               
               
                   
                   
                 ccttctgtgcctatcaaacaaatacatagcatgaanctaa 
               
               
                   
                   
                 ttttagaagtttcatgggggaattttaggggaaagtataa 
               
               
                   
                   
                 acctaagagtgagtgaatggagatgattcatggaaaaaaa 
               
               
                   
                   
                 aaanaaaaannnanatgtgctatnaggcagagttattaac 
               
               
                   
                   
                 ttcttttagttgttgtttgagatngngttctgctcttgtt 
               
               
                   
                   
                 ncccaggctggagtgcantggcgtgatctcgtctcnctgc 
               
               
                   
                   
                 aacctccgcctcccaggttcaagcgattctcctgccccag 
               
               
                   
                   
                 ctactttggaggctgaagtgtaagagttgcttgagc 
               
               
                   
               
               
                 62 
                 214953_s_at 
                 atagattctctcctgattatttatcacatagccccttagc 
               
               
                   
                   
                 cagttgtatattattcttgtggtttgtgacccaattaagt 
               
               
                   
                   
                 cctactttacatatgctttaagaatcgatgggggatgctt 
               
               
                   
                   
                 catgtgaacgtgggagttcagctgcttctcttgcctaagt 
               
               
                   
                   
                 attcctttcctgatcactatgcattttaaagttaaacatt 
               
               
                   
                   
                 tttaagtatttcagatgctttagagagattttttttccat 
               
               
                   
                   
                 gactgcattttactgtacagattgctgcttctgctatatt 
               
               
                   
                   
                 tgtgatataggaattaagaggatacacacgtttgtttctt 
               
               
                   
                   
                 cgtgcctgttttatgtgcacacattaggcattgagacttc 
               
               
                   
                   
                 aagcttttctttttttgtccacgtatctttgggtctttga 
               
               
                   
                   
                 taaagaaaagaatccctgttcattgtaagcacttttacgg 
               
               
                   
                   
                 ggcgggtg 
               
               
                   
               
               
                 63 
                 215726_s_at 
                 gacagaccaaagttaaacaagcctccggaaactcttatca 
               
               
                   
                   
                 ctactattgattctagttccagttggtggaccaactgggt 
               
               
                   
                   
                 gatccctgccatctctgcagtggccgtcgccttgatgtat 
               
               
                   
                   
                 cgcctatacatggcagaggactgaacacctcctcagaagt 
               
               
                   
                   
                 cagcgcaggaagagcctgctttggacacgggagaaaagaa 
               
               
                   
                   
                 gccattgctaactacttcaactgacagaaaccttcacttg 
               
               
                   
                   
                 aaaacaatgattttaatatatctctttctttttcttccga 
               
               
                   
                   
                 cattagaaacaaaacaaaaagaactgtcctttctgcgcnc 
               
               
                   
                   
                 aaatttttcgagtgtgcctttttattcatctactttattt 
               
               
                   
                   
                 tgatgtttccttaatgtgtaatt 
               
               
                   
               
               
                 64 
                 216016_at 
                 gccaatgctaaaaagctgcagatccagcccagccagctgg 
               
               
                   
                   
                 aattgttctactgtttgtacgagatgcaggaggaggactt 
               
               
                   
                   
                 cgtgcaaagggccatggactatttccccaagattgagatc 
               
               
                   
                   
                 aatctctccaccagaatggaccacatggtttcttcctttt 
               
               
                   
                   
                 gcattgagaactgtcatcgggtggagtcactgtccctggg 
               
               
                   
                   
                 gtttctccataacatgcccaaggaggaagaggaggaggaa 
               
               
                   
                   
                 aaggaaggccgacaccttgatatggtgcagtgtgtcctcc 
               
               
                   
                   
                 caagctcctctcatgctgcctgttctcatgggtaaggaaa 
               
               
                   
                   
                 ctcggcttccaggtgcttcctcctgcttcctcgccagctt 
               
               
                   
                   
                 cttcttggcacctgcctcctctcatctcttttcaactatc 
               
               
                   
                   
                 ttccaaatactgttgccacagctacatcataatgccacca 
               
               
                   
                   
                 ctgtctgtttgagactccttcatgagcaaagattgatgta 
               
               
                   
                   
                 tggtaggtggat 
               
               
                   
               
               
                 65 
                 217722_s_at 
                 ggagatgcctcgtgaaacacagctgggcaagtattaatgt 
               
               
                   
                   
                 atatggaacagcctggatttctgcatatggataagccacc 
               
               
                   
                   
                 ttggaataggaagaggtgttgagcctggactgtgggagga 
               
               
                   
                   
                 aagagctgcgtggatagattcaaacttcctgtggtagtgc 
               
               
                   
                   
                 tcccagtctgacctctgtagaccttcagtactcactcttc 
               
               
                   
                   
                 ttgcttaggctctctgtgtgttgaaagccatcccgtgttg 
               
               
                   
                   
                 catgtgttgttacaattttctgtgatacttgcaat 
               
               
                   
               
               
                 66 
                 217753_s_at 
                 tggtcgtgccaaaaagggccgcggccacgtgcagcctatt 
               
               
                   
                   
                 cgctgcactaactgtgcccgatgcgtgcccaaggacaagg 
               
               
                   
                   
                 ccattaagaaattcgtcattcgaaacatagtggaggccgc 
               
               
                   
                   
                 agcagtcagggacatttctgaagcgagcgtcttcgatgcc 
               
               
                   
                   
                 tatgtgcttcccaagctgtatgtgaagctacattactgtg 
               
               
                   
                   
                 tgagttgtgcaattcacagcaaagtagtcaggaatcgatc 
               
               
                   
                   
                 tcgtgaagcccgcaaggaccgaacacccccaccccgattt 
               
               
                   
                   
                 agacctgcgggtgctgccccagctcccccaccaaagccca 
               
               
                   
                   
                 tgtaaggagctgagttctt 
               
               
                   
               
               
                 67 
                 217970_s_at 
                 tgagctggagctggttggactaatgagactgagg 
               
               
                   
                   
                 aagcagcttttcctacgatctgcattatgtaatc 
               
               
                   
                   
                 acaggtccagagagctttatggaagcgggagagg 
               
               
                   
                   
                 aggagcacttactcatgttgtatttgttaatgga 
               
               
                   
                   
                 ggatgtcatcttttcatagatgctagaactagag 
               
               
                   
                   
                 tgcacttgttagatgctaaaggtttgagctttac 
               
               
                   
                   
                 acaaaatgtcttcatctgtatttgttattgtcta 
               
               
                   
                   
                 caatatatttgaatttggggcagcatattaagat 
               
               
                   
                   
                 gtaatggcctgttatgtcttgaaaatacttgttt 
               
               
                   
                   
                 tgcctcttccaggcatactgcattctgtggatca 
               
               
                   
                   
                 gtttgaacagcttctccaccttatttggacagtg 
               
               
                   
                   
                 ataaattgaaccaagagtgtagatttacaagtgt 
               
               
                   
                   
                 aaccttcaaaagaggaagaactatttggggtctg 
               
               
                   
                   
                 taggtaatgaacagtcacaccaaaatagactatg 
               
               
                   
                   
                 atgcttttgttaagaaaggtttcatgttttagat 
               
               
                   
                   
                 attttccgtgtcctaaataatt 
               
               
                   
               
               
                 68 
                 218190_s_at 
                 tgaagaaacatggcggccgcgacgttgacttcgaaattgt 
               
               
                   
                   
                 actccctgctgttccgcaggacctccaccttcgccctcac 
               
               
                   
                   
                 catcatcgtgggcgtcatgttcttcgagcgcgccttcgat 
               
               
                   
                   
                 caaggcgcggacgctatctacgaccacatcaacgagggga 
               
               
                   
                   
                 agctgtggaaacacatcaagcacaagtatgagaacaagta 
               
               
                   
                   
                 gttccttggaggcccccatccaggccagaaggaccaggtc 
               
               
                   
                   
                 cacccagcagctgtttgcccagagctggagcctcagcttg 
               
               
                   
                   
                 aagatgatgctcaaggtactcttcatggaccaccattcgc 
               
               
                   
                   
                 tgttggcaagaaacggctttacttacaaaacagactcttt 
               
               
                   
                   
                 accttctgctgtgtttgaa 
               
               
                   
               
               
                 69 
                 218345_at 
                 gatttccgatatggctactcttattacaacagtgcctgcc 
               
               
                   
                   
                 gcatctccagctcgagtgactggaacactccagcccccac 
               
               
                   
                   
                 tcagagtccagaagaagtcagaaggctacacctatgtacc 
               
               
                   
                   
                 tccttcatggacatgctgaaggccttgttcagaacccttc 
               
               
                   
                   
                 aggccatgctcttgggtgtttggattctgctgcttctggc 
               
               
                   
                   
                 atctctggcccctctgtggctgtactgctggagaatgttc 
               
               
                   
                   
                 ccaaccaaagggaaaagagaccagaaggaaatgttggaag 
               
               
                   
                   
                 tgagtggaatctagccatgcctctcctgattattagtgcc 
               
               
                   
                   
                 tggtgcttctgcaccgggcgtccctgcatctgactgctgg 
               
               
                   
                   
                 aagaagaaccagactgaggaaaagaggcttttcaacagcc 
               
               
                   
                   
                 ccagttatcctggccccatgaccgtggccacagccctgct 
               
               
                   
                   
                 ccagcagcacttgcccattccttacaccccttccccatcc 
               
               
                   
                   
                 tgctccgcttcatgtcccctcctgagtagtcatgtgataa 
               
               
                   
                   
                 taaactctcatgttattgttcccag 
               
               
                   
               
               
                 70 
                 218486_at 
                 gactgtacacactataaatggcatcaaatttggatatttt 
               
               
                   
                   
                 tcttaattatgacatgcaaagtaatgtgagtcctgccagt 
               
               
                   
                   
                 attctggtggataaggtcttntgagtatttggttgcttgt 
               
               
                   
                   
                 cacaacattctccaagcagtgatatttctaaagaggagat 
               
               
                   
                   
                 acatgttgaaaacggttttaatttacacttccatttcctg 
               
               
                   
                   
                 attacatttggaaatactttgtgtaaaccatcccccttcc 
               
               
                   
                   
                 acctccatttgtctgttgaaagattttaagttggaaacag 
               
               
                   
                   
                 ttcctgtctgaaaactcttctgagaaccacaaaccttgtg 
               
               
                   
                   
                 tatggattcggcatggagccctcagctggcggctctgggt 
               
               
                   
                   
                 gctgacggccgctggagaggtgggctcccctcgtgcactt 
               
               
                   
                   
                 tattgcctgggcagttttgcttgatcttttgtgactttga 
               
               
                   
                   
                 gccttttaagtagtttgaatgataagacttaaaatgtttc 
               
               
                   
                   
                 ataattatgttttatgtaacagactttgacattatttaaa 
               
               
                   
                   
                 cgagcatgtgtaatgtaacttttctctttgaatcata 
               
               
                   
               
               
                 71 
                 218545_at 
                 agcatggatttcaacatcacttatttatctgtataattgg 
               
               
                   
                   
                 aaataaaacaccgatatgatagagaatcattccggcatta 
               
               
                   
                   
                 cctaacctcttctgcagttggatctatgtattttcattgg 
               
               
                   
                   
                 tctactgaaaacgaacaatacaattaaaagcactaaagat 
               
               
                   
                   
                 tattatattaattcaactttgatctgatatatcacttaaa 
               
               
                   
                   
                 ctaaaggggtgtgtgtggtgtatgcttgtttcctatttct 
               
               
                   
                   
                 gctctttaaagatactttgaatcaataaaaccattagtct 
               
               
                   
                   
                 acaaatcaaattgtgaacttaatctctagaaagagaatat 
               
               
                   
                   
                 aactcagccatttataggaatttaggttcaagtacaggat 
               
               
                   
                   
                 atatgaaatcttttcccagtatttcagaatgtacttaatt 
               
               
                   
                   
                 cacaggcaggatgcttcaatgcaaaatcatgaatattttt 
               
               
                   
                   
                 aattcaaaactaaaatgtcattaatatgtatgtatgcaaa 
               
               
                   
                   
                 tgttttatcttattttctgaaatgcatctactttcatggg 
               
               
                   
                   
                 ctttgtacgtttctgagattt 
               
               
                   
               
               
                 72 
                 218728_s_at 
                 atatcgatacattatggtgccgagtggtaacatgggagtg 
               
               
                   
                   
                 tttgatccaacagaaatacacaatcgagggcagctgaagt 
               
               
                   
                   
                 cacacatgaaagaagccatgatcaagcttggtttccactt 
               
               
                   
                   
                 gctctgcttcttcatgtatctttatagtatgatcttagct 
               
               
                   
               
               
                 73 
                 219269_at 
                 aggctagaaaatcttgctgctccgtcttagcattccaaga 
               
               
                   
                   
                 gagtgcttccaggtatttagatagccctcagttctcaaat 
               
               
                   
                   
                 attagactacgtgtaaaatcttgggtacctttagattctt 
               
               
                   
                   
                 gtaacactagtctgtactcccttttccttccccaagactg 
               
               
                   
                   
                 ataggatgcaagctgaggtcgtggcacaggaatgacagac 
               
               
                   
                   
                 accatttggggagtatccacagagtcaaaggaacactaga 
               
               
                   
                   
                 atccccacctcagcgtgaggataattgatttccagctgca 
               
               
                   
                   
                 ataagccgtgcctcattatagccacactgtggctagatta 
               
               
                   
                   
                 tacttctttgggtgctgtgctaagaatgtcaatggaaaaa 
               
               
                   
                   
                 gccgatctcagattttgtttgaagttaacatgcctgacac 
               
               
                   
                   
                 agacatcctttcctctcacaagctgtgtgacttagtagat 
               
               
                   
                   
                 aaaatactgccttctgccttt 
               
               
                   
               
               
                 74 
                 219410_at 
                 tgtttctcaccatatgcttttgttggcattatgcagtaac 
               
               
                   
                   
                 cattgtcatcgttggaatgaattatgctttcattacctgg 
               
               
                   
                   
                 ttggttaaatctagacttaagaggctctgctcctcagaag 
               
               
                   
                   
                 ttggacttctgaaaaatgctgaacgagaacaagaatcaga 
               
               
                   
                   
                 agaagaaatgtgactttgatgagcttccagtttttctaga 
               
               
                   
                   
                 taaaccttttcttttttacattgttcttggttttgtttct 
               
               
                   
                   
                 cgatcttttgtttggagaacagctggctaaggatgactct 
               
               
                   
                   
                 aagtgtactgtttgcatttccaatttggttaaagtatttg 
               
               
                   
                   
                 aatttaaatattttctttttagctttgaaaatattttggg 
               
               
                   
                   
                 tgatactttcattttgcacatcatgcacatcatggtattc 
               
               
                   
                   
                 aggggctagagtgatttttttccagattatctaaagttgg 
               
               
                   
                   
                 atgcccacactatgaaagaaatatttgttttatttgcctt 
               
               
                   
                   
                 atagatatgctcaaggttactgggcttgctactatttgta 
               
               
                   
                   
                 actccttgaccatggaattatacttgtttatcttgttgct 
               
               
                   
                   
                 gca 
               
               
                   
               
               
                 75 
                 219862_s_at 
                 cggccaaggagctgttcaacgaggatgtggagga 
               
               
                   
                   
                 ggtcacttaccgagccctgagaaacaaagacttc 
               
               
                   
                   
                 caagaggtcacccttgagaagaacggagaggtgg 
               
               
                   
                   
                 tgttacgctttgctgcagcctatggctttcgaaa 
               
               
                   
                   
                 catccagaacatgatcctgaagcttaagaagggc 
               
               
                   
                   
                 aagttcccattccactttgtggaggtcctcgcct 
               
               
                   
                   
                 gtgctggaggatgcttaaatggcagaggccaagc 
               
               
                   
                   
                 ccagactccagacggacatgcggataaggccctg 
               
               
                   
                   
                 ctgcggcagatggaaggcatttacgctgacatcc 
               
               
                   
                   
                 ctgtgcggcgtccggagtccagtgcacacgtgca 
               
               
                   
                   
                 ggagctgtaccaggagtggctggaggggatcaac 
               
               
                   
                   
                 tcccccaaggcccgagaggtgctgcataccacgt 
               
               
                   
                   
                 accagagccaggagcgtggcacacacagcctgga 
               
               
                   
                   
                 catcaagtggtgaagtcaggccagggcctt 
               
               
                   
               
               
                 76 
                 219905_at 
                 ggctcacgtgattatggaggcggttaaatcccaa 
               
               
                   
                   
                 gatctgcaggataagtcagcaagatggagtccca 
               
               
                   
                   
                 tgagagctgatggtttagttccagtctgatggca 
               
               
                   
                   
                 gcaggcttgacgccaaggaagagatgatgtttaa 
               
               
                   
                   
                 ttcaagtccgaaggcaaggaaaaagctgatggtc 
               
               
                   
                   
                 ctgtccaaaggctattaggcaggaagaattctct 
               
               
                   
                   
                 tagggcagagttagctcttttgttctattcaggc 
               
               
                   
                   
                 cttcaactgattcagcaaggcccgcccacatttg 
               
               
                   
                   
                 ggaggacagtctgcattactcagtctactgattt 
               
               
                   
                   
                 gaatgttaatgtcattgcgaaacaccctcacagg 
               
               
                   
                   
                 aacactcagaataatgtttgaccaaatagctggg 
               
               
                   
                   
                 catcttgtgacccagttaagtg 
               
               
                   
               
               
                 77 
                 220532_s_at 
                 atctggcaaactgaaccctttttatacatcgacactgtgt 
               
               
                   
                   
                 gtgatcgctcagaccctgtcttccctaccactgggtacag 
               
               
                   
                   
                 atggatgcggcgaagtcaagagaaccaatggcagaaggag 
               
               
                   
                   
                 gagtgtagagcttacatgcagatgctgaggaagttgttca 
               
               
                   
                   
                 cagcaatccgtgccctgttcctggctgtctgtgtcttgaa 
               
               
                   
                   
                 ggtcattgtgtccttggtttccttgggagtaggtcttcga 
               
               
                   
                   
                 aacttgtgtggccagagctcccagcccctgaatgaggaag 
               
               
                   
                   
                 gatcagagaagaggctactgggggagaattcagtgccccc 
               
               
                   
                   
                 ttcgccctctagggagcagacctccactgccattgtcctg 
               
               
                   
                   
                 tgagccgccaaagaccccacggggtgcccgcatgtccctg 
               
               
                   
                   
                 tctagggcagcccagggcccccactcctggctcctcacac 
               
               
                   
                   
                 ttgcctcccctatggccgctctccagaccctcctcctttc 
               
               
                   
                   
                 ttctccccacatccgcacctgctgttcccactctggggtt 
               
               
                   
                   
                 ctcaagtccatga 
               
               
                   
               
               
                 78 
                 221011_s_at 
                 gagtggttcatccatactctcattccctcgcctccccttg 
               
               
                   
                   
                 tggacgggggtcttgccttttcaattcctgtgttttggtg 
               
               
                   
                   
                 tcttcccttatctgctaccctgaatcacctgtcctggtct 
               
               
                   
                   
                 tgctgtgtgatgggaacatgcttgtaaactgcgtaacaaa 
               
               
                   
                   
                 tctactttgtgtatgtgtctgtttatgggggtggtttatt 
               
               
                   
                   
                 atttttgctggtccctagaccactttgtatgaccgtttgc 
               
               
                   
                   
                 agtctgagcaggccaggggctgacagctaatgtcaggacc 
               
               
                   
                   
                 ctcagcggtggagcctgctggggggacccagctgctcttg 
               
               
                   
                   
                 gacaagtggctgagctcctatctggcctcctctttttttt 
               
               
                   
                   
                 ttttttcaagtaatttgtgtgtatttctaactgattgtat 
               
               
                   
                   
                 tgaaaaaattcctagtatttcagtaaaaatgcctgttgtg 
               
               
                   
                   
                 agatgaacctcctgtaacttctatctgttcttttttgagg 
               
               
                   
                   
                 ctcaggga 
               
               
                   
               
               
                 79 
                 221042_s_at 
                 tgaccccatggacagccatcagtcccaggaatcc 
               
               
                   
                   
                 ccaaacctggaaaacatagcaaaccccctagaag 
               
               
                   
                   
                 aaaatgtaacgaaagaatcaatcagtagtaaaaa 
               
               
                   
                   
                 aaaggaaaaaaggaaacatgtggaccacgtagaa 
               
               
                   
                   
                 agttcactatttgtagcaccaggaagtgttcaat 
               
               
                   
                   
                 cctcagatgacctagaagaagacagtagcgacta 
               
               
                   
                   
                 cagcattccttccaggactagtcacagtgactcc 
               
               
                   
                   
                 agcatttaccttcgacgacatactcataggtctt 
               
               
                   
                   
                 cggaatcggatcattttagctatgttcagttgag 
               
               
                   
                   
                 gaacgcagcagatctggatgacagaagaaaccga 
               
               
                   
                   
                 atattaaccaggaaggccaacagctcaggagaag 
               
               
                   
                   
                 ccatgtcactggggagccacagcccgcagagtga 
               
               
                   
                   
                 ctccctgacacagcttgtccagcagccggatatg 
               
               
                   
                   
                 atgtattttattctcttcctgtggctcctggtgt 
               
               
                   
                   
                 actgcttgctgctcttcccacaactggatgttag 
               
               
                   
                   
                 caggctctgatacgtg 
               
               
                   
               
               
                 80 
                 221434_s_at 
                 cctcagcagcgcgaggtgctgcggcgctgcgtagaagtat 
               
               
                   
                   
                 caatcagccggttgcttttgtgagaagaattccttggact 
               
               
                   
                   
                 gcggcgtcgagtcagctgaaagaacactttgcacagttcg 
               
               
                   
                   
                 gccatgtcagaaggtgcattttaccttttgacaaggagac 
               
               
                   
                   
                 tggctttcacagaggtttgggttgggttcagttttcttca 
               
               
                   
                   
                 gaagaaggacttcggaatgcactacaacag 
               
               
                   
               
               
                 81 
                 221737_at 
                 gaaatctatttttaactcttatgttcgtagagaaattgtt 
               
               
                   
                   
                 tcaaggattttgagtcataggtctgtaatttatagagatc 
               
               
                   
                   
                 tctagaattcttattgtaattttcctacttctttgataaa 
               
               
                   
                   
                 agaaaaataagtcagattgttaactccaagattgaaaaaa 
               
               
                   
                   
                 aaaactcttgaaagaagattattagttgtaactaatttgg 
               
               
                   
                   
                 gggttctgggcacagacatctaacctggtattgtaaggca 
               
               
                   
                   
                 gaggctcccattggaatggtagtggtccgggtcagttgtt 
               
               
                   
                   
                 catggtgtaagctttgcacagtgtattaacattgggaggg 
               
               
                   
                   
                 tctggcttgaaaatttggccaccctcagcc 
               
               
                   
               
               
                 82 
                 AFFX- 
                 tagttttaccctactgatgatgtgttgttgccat 
               
               
                   
                 M27830_5_at 
                 ggtaatcctgctcagtacgagaggaaccgcaggt 
               
               
                   
                   
                 tcagacatttggtgtatgtgcttggctga 
               
               
                   
               
               
                 83 
                 36711_at 
                 ttgcacggatctaagttattctccccagccagag 
               
               
                   
                   
                 cccgngctnnctgctcccngggaaaagntggcgt 
               
               
                   
                   
                 antggncctgagctgggntttatattttatatct 
               
               
                   
                   
                 gcaaataaatnacattttatcntanatttaggga 
               
               
                   
                   
                 aagccngagagnaacaacaaaaaatgtttaagcc 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnntattgcccggc 
               
               
                   
                   
                 tcctagaatttatttatttcctgacttacagcaagcgagttatcgtcttc 
               
               
                   
                   
                 tgtattttg 
               
               
                   
               
               
                 84 
                 38037_at 
                 ccactctatgagttggacttcagtcttgcctaggcgattt 
               
               
                   
                   
                 tgtctaccatttgtgttttgaaagcccaaggtgctgatgt 
               
               
                   
                   
                 caaagtgtaacagatatcagtgtctccccgtgtcctctcc 
               
               
                   
                   
                 ctgncaagtctcagaagaggttgggcttccatgcctgtag 
               
               
                   
                   
                 ctttcctggtccctcacccccatngccccaggcccacagc 
               
               
                   
                   
                 gtgggaactcactttcccttgtgtcaagacatttctnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnactccatgcaggggtcag 
               
               
                   
                   
                 tgcagcagaggacagtctggagaaggtattagcaaagcaa 
               
               
                   
                   
                 aaggctgagaaggaacagggaacattggagctgactgttc 
               
               
                   
                   
                 ttggtaactgattacctgccaattgctaccgagaaggttg 
               
               
                   
                   
                 gaggtggggaaggctttgtataatcccacccacctcacca 
               
               
                   
                   
                 aaacgannnnnnnnnnnnnnnnnngtcctttctggaagtt 
               
               
                   
                   
                 tctggtgccatttc 
               
               
                   
               
               
                 85 
                 201386_s_at 
                 Ggagatcatctgacactgctgaacgtctaccatgctttta 
               
               
                   
                   
                 aacaaaatcatgaatcggttcagtggtgttatgacaactt 
               
               
                   
                   
                 cattaactacaggtccctgatgtccgcagacaatgtacgc 
               
               
                   
                   
                 cagcagctatctcgaattatggacagatttaatttgcctc 
               
               
                   
                   
                 gtcgaagtactgactttacaagcagggactattatattaa 
               
               
                   
                   
                 tataagaaaagctttggttactgggtattttatgcaggtg 
               
               
                   
                   
                 gcacatttagaacgaacagggcattacttaactgtgaaag 
               
               
                   
                   
                 ataaccaggtggttcagttgcatccctctactgttcttga 
               
               
                   
                   
                 ccacaaacctgaatgggtgctttataatgagtttgttcta 
               
               
                   
                   
                 acaacaaagaattacatccggacatgtacagatatcaagc 
               
               
                   
                   
                 cagaatggttggtgaaaattgcccctcaatattatgacat 
               
               
                   
                   
                 gagcaatttcccacagtgtgaagcaaagagacagttggac 
               
               
                   
                   
                 cgcatcattgcc 
               
               
                   
               
               
                 86 
                 201890_at 
                 gctactttgaattaatctgcctttatgtttgggagaagaa 
               
               
                   
                   
                 agctgagacattgcatgaaagatgatgagagataaatgtt 
               
               
                   
                   
                 gatcttttggccccatttgttaattgtattcagtatttga 
               
               
                   
                   
                 acgtcgtcctgtttattgttagttttcttcatcatttatt 
               
               
                   
                   
                 gtatagacaatttttaaatctctgtaatatgatacatttt 
               
               
                   
                   
                 cctatcttttaagttattgttacctaaagttaatccagat 
               
               
                   
                   
                 tatatggtccttatatgtgtacaacattaaaatgaaaggc 
               
               
                   
                   
                 tttgtcttgcattgtgaggtacaggcggaagttggaatca 
               
               
                   
                   
                 ggttttaggattctgtctctcattagctgaataatgtgag 
               
               
                   
                   
                 gattaacttctgccagct 
               
               
                   
               
               
                 87 
                 202219_at 
                 aagcttcgagctgttgcgtgtgtgagtctgttgtgtggat 
               
               
                   
                   
                 gtgcgtgtgtggtccccagccccagactggattggaaaag 
               
               
                   
                   
                 tgcatggtgggggcctcggggctgtccccacgctgtccct 
               
               
                   
                   
                 ttgccacaagtctatggggcaagaggctgcaatattccgt 
               
               
                   
                   
                 cctgggtgtctgggctgctaacctggcctgctcaggcttc 
               
               
                   
                   
                 ccaccctgtgcggggcacacccccaggaagggaccctgga 
               
               
                   
                   
                 cacggctcccacgtccaggcttaaggtggatgcacttccc 
               
               
                   
                   
                 gcacctccagtcttctgtgtagcagctttaacccacgttt 
               
               
                   
                   
                 gtctgtcacgtccagtcccgagacggctgagtgaccccaa 
               
               
                   
                   
                 gaaaggcttccccgacacccagacagaggctgcagggctg 
               
               
                   
                   
                 gggctgggtgagggtggcgggcctgcggggacattctact 
               
               
                   
                   
                 gtgctaaa 
               
               
                   
               
               
                 88 
                 202464_s_at 
                 tattctgtcctgagaccacgggcaaagctcttccattttg 
               
               
                   
                   
                 agagagaagaaaaactgtttggaaccacaccaatgatatt 
               
               
                   
                   
                 tttctttgtaatacttgaaatttatttttttattattttg 
               
               
                   
                   
                 atagcagatgtgctatttatttatttaatatatgtataag 
               
               
                   
                   
                 gagtcctaaacaatagaaagctgtagaagctgtagagata 
               
               
                   
                   
                 ggcttcagttgttaattggtttggagcctcctatgtgtga 
               
               
                   
                   
                 cttatgactctctgtgttctgtgtatttgtctgaattaat 
               
               
                   
                   
                 gacctgggatataaagctatgctagctttcaaacaggaga 
               
               
                   
                   
                 tgccttcagaaagctttgtatattttgcagttgccagacc 
               
               
                   
                   
                 aataaaatacc 
               
               
                   
               
               
                 89 
                 203115_at 
                 aactccaattcaggagcccttgcgagtatatctgaagcac 
               
               
                   
                   
                 ttatttgctaaggaaacctgaattgatancagtactgtgc 
               
               
                   
                   
                 tgtctggaataatgtccttgatactgagttgggaccagac 
               
               
                   
                   
                 tggcttttatagtgacaggcaaagaggaatttattgagat 
               
               
                   
                   
                 cactgctcatggcatttgttgctgtaagaagtgttgcctt 
               
               
                   
                   
                 tgattgttactaaccacggatgggtaacggtcatacatta 
               
               
                   
                   
                 ggctagtgtttggtaggacaaaatctttttagagctttga 
               
               
                   
                   
                 gaattgtcatcctgttggtcaactttgaaatacaaatgtt 
               
               
                   
                   
                 tgccctggtaattagcaatgaactgctggcagtttcttca 
               
               
                   
                   
                 gctgtgtatatacggatctggcttttaattgatgaatcaa 
               
               
                   
                   
                 cttctacagaaacttttgcagggacagtgttgatgaggca 
               
               
                   
                   
                 gtttagcttgccagggtgatgataaagcccaggtccctgc 
               
               
                   
                   
                 atgtatagtgctcttctaaagaatatgcattcttgaacta 
               
               
                   
                   
                 cttaactttt 
               
               
                   
               
               
                 90 
                 203574_at 
                 gtatggtacattcttctcttactcctttctcagtgcaagt 
               
               
                   
                   
                 gactaacattcaagattggtctctcaaatcggagcactgg 
               
               
                   
                   
                 catcaaaaagaactgagtggcaaaactcagaatagtttca 
               
               
                   
                   
                 aaactggagttgttgaaatgaaagacagtggctacaaagt 
               
               
                   
                   
                 ttctgacccagagaacttgtatttgaagcaggggatagca 
               
               
                   
                   
                 aacttatctgcagaggttgtctcactcaagagacttatag 
               
               
                   
                   
                 ccacacaaccaatctctgcttcagactctgggtaaattac 
               
               
                   
                   
                 tactgagtaagagctgggcatttagaaagatgtcatttgc 
               
               
                   
                   
                 aatagagcagtccattttgtattatgctgaattttcactg 
               
               
                   
                   
                 gacctgtgatgtcatttcactgtgatgtgcacatgttgtc 
               
               
                   
                   
                 tgtttggtgtctttttgtgcacagattatgatgaagatta 
               
               
                   
                   
                 gattgtgttatcactctgcctgtgtatagtcagatagtcc 
               
               
                   
                   
                 atgcgaaggctgtatat 
               
               
                   
               
               
                 91 
                 203887_s_at 
                 cagggggtgtgtctgctcagtaatttgaggacaaccattc 
               
               
                   
                   
                 cagactgcttccaattttctggaatacatgaaatatagat 
               
               
                   
                   
                 cagttataagtagcaggccaagtcaggcccttattttcaa 
               
               
                   
                   
                 gaaactgaggaattttctttgtgtagctttgctctttggt 
               
               
                   
                   
                 agaaaaggctaggtacacagctctagacactgccacacag 
               
               
                   
                   
                 ggtctgcaaggtctttggttcagctaagctaggaatgaaa 
               
               
                   
                   
                 tcctgcttcagtgtatggaaataaatgtatcatagaaatg 
               
               
                   
                   
                 taacttttgtaagacaaaggttttcctcttctattttgta 
               
               
                   
                   
                 aactca 
               
               
                   
               
               
                 92 
                 203932_at 
                 tcttacggggacacttacacctgtgtggtagagcacattg 
               
               
                   
                   
                 gggctcctgagcccatccttcgggactggacacctgggct 
               
               
                   
                   
                 gtcccccatgcagaccctgaaggtttctgtgtctgcagtg 
               
               
                   
                   
                 actctgggcctgggcctcatcatcttctctcttggtgtga 
               
               
                   
                   
                 tcagctggcggagagctggccactctagttacactcctct 
               
               
                   
                   
                 tcctgggtccaattattcagaaggatggcacatttcctag 
               
               
                   
                   
                 aggcagaatcctacaacttccactccaagtgagaaggaga 
               
               
                   
                   
                 ttcaaactcaatgatgctaccatgcctctccaacatcttc 
               
               
                   
                   
                 aaccccctgacattatcttggatcctatggtttctccatc 
               
               
                   
                   
                 caattctttgaatttcccagtctcccctatgtaaaactta 
               
               
                   
                   
                 gcaacttgggggacctcattcctgggactatgctgtaacc 
               
               
                   
                   
                 aaattattgtccaaggctatatttctgggatgaatataat 
               
               
                   
                   
                 ctgaggaagggagttaaagaccctcctggggctctcagtg 
               
               
                   
                   
                 tgccatagaggac 
               
               
                   
               
               
                 93 
                 204131_s_at 
                 ttaccattccgggttcgagcatcacaagcttttgagcgca 
               
               
                   
                   
                 tggaactccataaactaacaaattacataaactaaagggg 
               
               
                   
                   
                 gattttctttcttcttttgtttggtagaaaattatccttt 
               
               
                   
                   
                 tctaaaaactgaacaatggcacaattgtttgctatgtgca 
               
               
                   
                   
                 cccgtccaggacagaaccgtgcataggcaaaaggagtgga 
               
               
                   
                   
                 gcacagcgtccggcccagtgtgtttccggttctgagtcag 
               
               
                   
                   
                 ggtgatctgtggacgggaccccagcaccaagtctacgggt 
               
               
                   
                   
                 gccagatcagtagggcctgtgatttcctgtcagtgtcctc 
               
               
                   
                   
                 agctaatgtgaacagtgttggtctgctggttagaaactag 
               
               
                   
                   
                 aatattgatattttcaggaaagaaatcagctcagctctcc 
               
               
                   
                   
                 actcattgccaaatgtcac 
               
               
                   
               
               
                 94 
                 204419_x_at 
                 acactcgcttctggaacgtctgaggttatcaataagctcc 
               
               
                   
                   
                 tagtccagacgccatgggtcatttcacagaggaggacaag 
               
               
                   
                   
                 gctactatcacaagcctgtggggcaaggtgaatgtggaag 
               
               
                   
                   
                 atgctggaggagaaaccctgggaaggctcctggttgtcta 
               
               
                   
                   
                 cccatggacccagaggttctttgacagctttggcaacctg 
               
               
                   
                   
                 tcctctgcctctgccatcatgggcaaccccaaagtcaagg 
               
               
                   
                   
                 cacatggcaagaaggtgctgacttccttgggagatgccat 
               
               
                   
                   
                 aaagcacctggatgatctcaagggcacctttgcccagctg 
               
               
                   
                   
                 agtgaactgcactgtgacaagctgcatgtggatcctgaga 
               
               
                   
                   
                 acttcaagctcctgggaaatgtgctggtgaccgttttggc 
               
               
                   
                   
                 aatccatttcggcaaagaattcacccctgaggtgcaggct 
               
               
                   
                   
                 tcctggcagaagatggtgactggagtggccaatgccctgt 
               
               
                   
                   
                 cctccagataccactgagctcactgcc 
               
               
                   
               
               
                 95 
                 204467_s_at 
                 ctcggaattccctgaagcaacactgccagaagtgtgtttt 
               
               
                   
                   
                 ggtatgcactggttccttaagtggctgtgattaattattg 
               
               
                   
                   
                 aaagtggggtgttgaagaccccaactactattgtagagta 
               
               
                   
                   
                 gtctatttctcccttcaatcctgtcaatgtttgctttatg 
               
               
                   
                   
                 tattttggggaactgttgtttgatgtgtatgtgtttataa 
               
               
                   
                   
                 ttgttatacatttttaattgagccttttattaacatatat 
               
               
                   
                   
                 tgttatttttgtctcgaaataattttttagttaaaatcta 
               
               
                   
                   
                 ttttgtctgatattggtgtgaatgctgta 
               
               
                   
               
               
                 96 
                 204848_x_at 
                 acactcgcttctggaacgtctgagattatcaataagctcc 
               
               
                   
                   
                 tagtccagacgccatgggtcatttcacagaggaggacaag 
               
               
                   
                   
                 gctactatcacaagcctgtggggcaaggtgaatgtggaag 
               
               
                   
                   
                 atgctggaggagaaaccctgggaaggctcctggttgtcta 
               
               
                   
                   
                 cccatggacccagaggttctttgacagctttggcaacctg 
               
               
                   
                   
                 tcctctgcctctgccatcatgggcaaccccaaagtcaagg 
               
               
                   
                   
                 cacatggcaagaaggtgctgacttccttgggagatgccat 
               
               
                   
                   
                 aaagcacctggatgatctcaagggcacctttgcccagctg 
               
               
                   
                   
                 agtgaactgcactgtgacaagctgcatgtggatcctgaga 
               
               
                   
                   
                 acttcaagctcctgggaaatgtgctggtgaccgttttggc 
               
               
                   
                   
                 aatccatttcggcaaagaattcacccctgaggtgcaggct 
               
               
                   
                   
                 tcctggcagaagatggtgactgcagtggccagtgccctgt 
               
               
                   
                   
                 cctccagataccactgagcctcttgcccatgattcagagc 
               
               
                   
                   
                 t 
               
               
                   
               
               
                 97 
                 205239_at 
                 atttcaaaatttctgcattcacggagaatgcaaatatata 
               
               
                   
                   
                 gagcacctggaagcagtaacatgcaaatgtcagcaagaat 
               
               
                   
                   
                 atttcggtgaacggtgtggggaaaagtccatgaaaactca 
               
               
                   
                   
                 cagcatgattgacagtagtttatcaaaaattgcattagca 
               
               
                   
                   
                 gccatagctgcctttatgtctgctgtgatcctcacagctg 
               
               
                   
                   
                 ttgctgttattacagtccagcttagaagacaatacgtcag 
               
               
                   
                   
                 gaaatatgaaggagaagctgaggaacgaaagaaacttcga 
               
               
                   
                   
                 caagagaatggaaatgtacatgctatagcataactgaaga 
               
               
                   
                   
                 taaaattacaggatatcacattggagtcactgccaagtca 
               
               
                   
                   
                 tagccataaatgatgactcggtcctctttccagtggatca 
               
               
                   
                   
                 taagacaatggaccctttttgttatgatggttttaaactt 
               
               
                   
                   
                 tcaattgtcactttttatgctatttctgtata 
               
               
                   
               
               
                 98 
                 205571_at 
                 gatcaggagcaatgccactgctagcataccttccttagtg 
               
               
                   
                   
                 aaaaatcttttggaaaaggatcccactctgacctgtgaag 
               
               
                   
                   
                 tactaatgaatgctgttgctacagagtatgctgcctatca 
               
               
                   
                   
                 tcaaattgataatcacattcacctaataaacccaacggat 
               
               
                   
                   
                 gagacactgtttcctggaataaatagcaaagccaaagaac 
               
               
                   
                   
                 tgcaaacttgggagtggatatatggcaaaactccaaagtt 
               
               
                   
                   
                 tagtataaatacttcctttcatgtgttatatgaacagtca 
               
               
                   
                   
                 cacttggaaattaaagtattcatagacataaagaatggaa 
               
               
                   
                   
                 gaattgaaatttgtaatattgaagcacctgatcattggtt 
               
               
                   
                   
                 gccattggaaatacgtgacaaattaaattcaagtcttatt 
               
               
                   
                   
                 ggcagtaagttttgcccaactgaaactaccatgctaacaa 
               
               
                   
                   
                 atatattacttagaacatgtccacaagaccacaaact 
               
               
                   
               
               
                 99 
                 205592_at 
                 tgggggccacagactcaacatgtgtgtgtggtggggttcc 
               
               
                   
                   
                 agcccaacatagagtaacattatttgtacctcccaggcta 
               
               
                   
                   
                 gctcagtccatgggaggctctcctgtccctgaaagctgac 
               
               
                   
                   
                 acccacctttcaccacttcgcccatgctacagttcagttt 
               
               
                   
                   
                 cctcgtctgtaaaatggggatgataatggtacctaccttg 
               
               
                   
                   
                 cagtgttgttataaggattaaaggagacagtgcaagaaaa 
               
               
                   
                   
                 ggccttggttggtgaagagcccaacctcggaggggagctg 
               
               
                   
                   
                 ctgggatcctccttatcttgactgggatgtccctgtctcc 
               
               
                   
                   
                 ccctccccttgctccttgaacatggccaaggaaagtgaaa 
               
               
                   
                   
                 aacaaaaattattcactctgctagcacccttccccttgat 
               
               
                   
                   
                 gcctgggaataggttttgccaa 
               
               
                   
               
               
                 100 
                 205863_at 
                 tagctccacattcctgtgcattgaggggttaacattaggc 
               
               
                   
                   
                 tgggaagatgacaaaacttgaagagcatctggagggaatt 
               
               
                   
                   
                 gtcaatatcttccaccaatactcagttcggaaggggcatt 
               
               
                   
                   
                 ttgacaccctctctaagggtgagctgaagcagctgcttac 
               
               
                   
                   
                 aaaggagcttgcaaacaccatcaagaatatcaaagataaa 
               
               
                   
                   
                 gctgtcattgatgaaatattccaaggcctggatgctaatc 
               
               
                   
                   
                 aagatgaacaggtcgactttcaagaattcatatccctggt 
               
               
                   
                   
                 agccattgcgctgaaggctgcccattaccacacccacaaa 
               
               
                   
                   
                 gagtaggtagctctctgaaggctttttacccagcaatgtc 
               
               
                   
                   
                 ct 
               
               
                   
               
               
                 101 
                 205900_at 
                 tcaagtcctctggtggcagttccagcgtgaggtttgtttc 
               
               
                   
                   
                 taccacttattccggagtaaccagataaagagatgccctc 
               
               
                   
                   
                 tgtttcattagctctagttctcccccagcatcactaacaa 
               
               
                   
                   
                 atatgcttggcaagaccgaggtcgatttgtcccagcctta 
               
               
                   
                   
                 ccggagaaaagagctatggttagttacactagctcatcct 
               
               
                   
                   
                 attcccccagctctttcttttctgctgtttcccaatgaag 
               
               
                   
                   
                 ttttcagatcagtggcaatctcagttcccttgctatgacc 
               
               
                   
                   
                 ctgctttgttctttcccgagaaacagttcagcagtgacca 
               
               
                   
                   
                 ccacccacatgacatttcaagcaccaccttaagccagcca 
               
               
                   
                   
                 gagtaggaccagttagacctagggtgtggacagctccttg 
               
               
                   
                   
                 catcttaacactgtgc 
               
               
                   
               
               
                 102 
                 205950_s_at 
                 gagccccattcacaaattttgacccctctactctccttcc 
               
               
                   
                   
                 ttcatccctggatttctggacctaccctggctctctgact 
               
               
                   
                   
                 catcctcctctttatgagagtgtaacttggatcatctgta 
               
               
                   
                   
                 aggagagcatcagtgtcagctcagagcagctggcacaatt 
               
               
                   
                   
                 ccgcagccttctatcaaatgttgaaggtgataacgctgtc 
               
               
                   
                   
                 cccatgcagcacaacaaccgcccaacccaacctctgaagg 
               
               
                   
                   
                 gcagaacagtgagagcttcattttgatgattctgagaaga 
               
               
                   
                   
                 aacttgtccttcctcaagaacacagccctgcttctgacat 
               
               
                   
                   
                 aatccagttaaaataataatttttaagaaataaatttatt 
               
               
                   
                   
                 tcaatattagcaagacagcatgccttcaaatcaatctgta 
               
               
                   
                   
                 aaactaagaaacttaaattttagttcttactgcttaattc 
               
               
                   
                   
                 aaataataattagtaagctagcaaatagtaatctgtaagc 
               
               
                   
                   
                 ataagcttatcttaaattcaagtttagtttgaggaattct 
               
               
                   
                   
                 ttaaaattacaactaagtgatttgtatgtctatttttttc 
               
               
                   
               
               
                 103 
                 205987_at 
                 ccagctgttgctggtttgtcatgcctccggcttctaccca 
               
               
                   
                   
                 aagcctgtttgggtgacatggatgcggaatgaacaggagc 
               
               
                   
                   
                 aactgggcactaaacatggtgatattcttcctaatgctga 
               
               
                   
                   
                 tgggacatggtatcttcaggtgatcctggaggtggcatct 
               
               
                   
                   
                 gaggagcctgctggcctgtcttgtcgagtgagacacagca 
               
               
                   
                   
                 gtctaggaggccaggacatcatcctctactggggacacca 
               
               
                   
                   
                 ctcttccatgaattggattgccttggtagtgatagtgccc 
               
               
                   
                   
                 ttggtgattctaatagtccttgtgttatggtttaagaagc 
               
               
                   
                   
                 actgctcatatcaggacatcctgtgagactcttccccctg 
               
               
                   
                   
                 actcccccattgtgttaagaacccagcaacccaggagcct 
               
               
                   
                   
                 agtacaatatagtgatgccatcccgtcgactctccattta 
               
               
                   
                   
                 aattgtt 
               
               
                   
               
               
                 104 
                 206025_s_at 
                 ggataccccattgtgaagccagggcccaactgtggatttg 
               
               
                   
                   
                 gaaaaactggcattattgattatggaatccgtctcaatag 
               
               
                   
                   
                 gagtgaaagatgggatgcctattgctacaacccacacgca 
               
               
                   
                   
                 aaggagtgtggtggcgtctttacagatccaaagcaaattt 
               
               
                   
                   
                 ttaaatctccaggcttcccaaatgagtacgaagataacca 
               
               
                   
                   
                 aatctgctactggcacattagactcaagtatggtcagcgt 
               
               
                   
                   
                 attcacctgagttttttagattttgaccttgaagatgacc 
               
               
                   
                   
                 caggttgcttggctgattatgttgaaatatatgacagtta 
               
               
                   
                   
                 cgatgatgtccatggctttgtgggaagatactgtggagat 
               
               
                   
                   
                 gagcttccagatgacatcatcagtacaggaaatgtcatga 
               
               
                   
                   
                 ccttgaagtttctaagtgatgcttcagtgacagctggagg 
               
               
                   
                   
                 tttccaaatcaaatatgttgcaatggatcctgtatccaaa 
               
               
                   
                   
                 tccagtcaag 
               
               
                   
               
               
                 105 
                 206111_at 
                 Gtttacctgggctcaatggtttgaaacccagcac 
               
               
                   
                   
                 atcaatatgacctcccagcaatgcaccaatgcaa 
               
               
                   
                   
                 tgcaggtcattaacaattatcaacggcgatgcaa 
               
               
                   
                   
                 aaaccaaaatactttccttcttacaacttttgct 
               
               
                   
                   
                 aacgtagttaatgtttgtggtaacccaaatatga 
               
               
                   
                   
                 cctgtcctagtaacaaaactcgcaaaaattgtca 
               
               
                   
                   
                 ccacagtggaagccaggtgcctttaatccactgt 
               
               
                   
                   
                 aacctcacaactccaagtccacagaatatttcaa 
               
               
                   
                   
                 actgcaggtatgcgcagacaccagcaaacatgtt 
               
               
                   
                   
                 ctatatagttgcatgtgacaacagagatcaacga 
               
               
                   
                   
                 cgagaccctccacagtatccggtggttccagttc 
               
               
                   
                   
                 acctggatagaatcatctaagctcctgtatcagc 
               
               
                   
                   
                 actcctcatcatcactcatctgccaagctcctcaatcatagcca 
               
               
                   
                   
                 agatcccatctctccatatactttggg 
               
               
                   
               
               
                 106 
                 206834_at 
                 Ggagaagactgctgtcaatgccctgtggggcaaa 
               
               
                   
                   
                 gtgaacgtggatgcagttggtggtgaggccctgg 
               
               
                   
                   
                 gcagattactggtggtctacccttggacccagag 
               
               
                   
                   
                 gttctttgagtcctttggggatctgtcctctcct 
               
               
                   
                   
                 gatgctgttatgggcaaccctaaggtgaaggctc 
               
               
                   
                   
                 atggcaagaaggtgctaggtgcctttagtgatgg 
               
               
                   
                   
                 cctggctcacctggacaacctcaagggcactttt 
               
               
                   
                   
                 tctcagctgagtgagctgcactgtgacaagctgc 
               
               
                   
                   
                 acgtggatcctgagaacttcaggctcttgggcaa 
               
               
                   
                   
                 tgtgctggtgtgtgtgctggcccgcaactttggc 
               
               
                   
                   
                 aaggaattcaccccacaaatgcaggctgcctatc 
               
               
                   
                   
                 agaaggtggtggctggtgtggctaatgccctggc 
               
               
                   
                   
                 tcacaagtaccattgagatcctggactgtttcct 
               
               
                   
                   
                 gataaccataagaagaccctatttccctagattc 
               
               
                   
                   
                 tattttctgaacttgggaacacaatgcctacttcaagggtatggcttc 
               
               
                   
               
               
                 107 
                 207332_s_at 
                 aaggagagtcccctgaaggtctgacacgtctgcctaccca 
               
               
                   
                   
                 ttcgtggtgatcaattaaatgtaggtatgaataagttcga 
               
               
                   
                   
                 agctccgtgagtgaaccatcatataaacgtgtagtacagc 
               
               
                   
                   
                 tgtttgtcatagggcagttggaaacggcctcctagggaaa 
               
               
                   
                   
                 agttcatagggtctcttcaggttcttagtgtcacttacct 
               
               
                   
                   
                 agatttacagcctcacttgaatgtgtcactactcacagtc 
               
               
                   
                   
                 tctttaatcttcagttttatctttaatctcctcttttatc 
               
               
                   
                   
                 ttggactgacatttagcgtagctaagtgaaaaggtcatag 
               
               
                   
                   
                 ctgagattcctggttcgggtgttacgcacacgtacttaaa 
               
               
                   
                   
                 tgaaagcatgtggcatgttcatcgtataacacaatatgaa 
               
               
                   
                   
                 tacagggcatgcattttgcagcagtgagtctcttcagaaa 
               
               
                   
                   
                 acccttttctacagttagggttgagttacttcctatcaag 
               
               
                   
                   
                 ccagtacgtgctaacaggctcaatattcctgaatgaaata 
               
               
                   
                   
                 tcagactagtgacaagctcctggtcttgagatgtcttctc 
               
               
                   
               
               
                 108 
                 208632_at 
                 aacccagaatggcacacactgctctgctgtagcatcatgt 
               
               
                   
                   
                 cagggcttcctggactcagtacacctctcagtttgtcttt 
               
               
                   
                   
                 taaaaaacagctgaatctttactacctatttagttctcct 
               
               
                   
                   
                 tgttaaagaaacaggggtgggaataaaatggatttaggna 
               
               
                   
                   
                 cacccagtttgaattgcagtttttttttttctgacacatg 
               
               
                   
                   
                 gccaggctgtggtgccagcttaatggagtaggctgtcctt 
               
               
                   
                   
                 ggcacttgcatgtgtgaaaggagggttttgcctcttcttg 
               
               
                   
                   
                 agcatggcttgagttggtaaggaaagctgtaactcacgaa 
               
               
                   
                   
                 gccctgagacctgctacccctaagatcgagcttgttttca 
               
               
                   
                   
                 gtgactggcttgagtcataggaggaggagtctggtacagc 
               
               
                   
                   
                 tgcaggagagcagggccatctgaagcggtagcattgccac 
               
               
                   
                   
                 catctccctctcatctagagcagttttcttatgccttggt 
               
               
                   
                   
                 tt 
               
               
                   
               
               
                 109 
                 209007_s_at 
                 gaagatggaactcgaaatcccaatgaaaaacctacccagc 
               
               
                   
                   
                 aaagaagcatagcttttagctctaataattctgtagcaaa 
               
               
                   
                   
                 gccaatacaaaaatcagctaaagctgccacagaagaggca 
               
               
                   
                   
                 tcttcaagatcaccaaaaatagatcagaaaaaaagtccat 
               
               
                   
                   
                 atggactgtggatacctatctaaaagaagaaaactgatgg 
               
               
                   
                   
                 ctaagtttgcatgaaaactgcactttattgcaagttagtg 
               
               
                   
                   
                 tttctagcattatcccatccctttgagccattcaggggta 
               
               
                   
                   
                 cttgtgcatttaaaaaccaacacaaaaagatgtaaatact 
               
               
                   
                   
                 taacactcaaatattaacattttaggtttctcttgcagat 
               
               
                   
                   
                 atgagagatagcacagatggaccaaaggttatgcacaggt 
               
               
                   
                   
                 gggagtcttttgtatatagttgtaaatattgtcttggtta 
               
               
                   
                   
                 tgtaaaaatgaaattttttagacacagtaattgaactgta 
               
               
                   
                   
                 ttcctgttttgtat 
               
               
                   
               
               
                 110 
                 209458_x_at 
                 agagaacccaccatggtgctgtctcctgccgacaagacca 
               
               
                   
                   
                 acgtcaaggccgcctggggtaaggtcggcgcgcacgctgg 
               
               
                   
                   
                 cgagtatggtgcggaggccctggagaggatgttcctgtcc 
               
               
                   
                   
                 ttccccaccaccaagacctacttcccgcacttcgacctga 
               
               
                   
                   
                 gccacggctctgcccaggttaagggccacggcaagaaggt 
               
               
                   
                   
                 ggccgacgcgctgaccaacgccgtggcgcacgtggacgac 
               
               
                   
                   
                 atgcccaacgcgctgtccgccctgagcgacctgcacgcgc 
               
               
                   
                   
                 acaagcttcgggtggacccggtcaacttcaagctcctaag 
               
               
                   
                   
                 ccactgcctgctggtgaccctggccgcccacctccccgcc 
               
               
                   
                   
                 gagttcacccctgcggtgcacgcctccctggacaagttcc 
               
               
                   
                   
                 tggcttctgtgagcaccgtgctgacctccaaataccgtta 
               
               
                   
                   
                 agctg 
               
               
                   
               
               
                 111 
                 209795_at 
                 tagtctaattgaatcccttaaactcagggagcatttataa 
               
               
                   
                   
                 atggcaaatgcttatgaaactaagatttgtaatatttctc 
               
               
                   
                   
                 tctttttagagaaatttgccaatttactttgttatttttc 
               
               
                   
                   
                 cccaaaaagaatgggatgatcgtgtatttatttttttact 
               
               
                   
                   
                 tcctcagctgtagacaggtccttttcgatggtacatattt 
               
               
                   
                   
                 ctttgcctttataatcttttatacagtgtcttacagagaa 
               
               
                   
                   
                 aagacataagcaaagactatgaggaatatttgcaagacat 
               
               
                   
                   
                 agaatagtgttggaaaatgtgcaatatgtgatgtggcaaa 
               
               
                   
                   
                 tctctattaggaaatattctgtaatcttcagacctagaat 
               
               
                   
                   
                 aatactagtcttataataggtttgtgactttcctaaatca 
               
               
                   
                   
                 attctattacgtgcaatacttcaatacttcat 
               
               
                   
               
               
                 112 
                 210027_s_at 
                 Tgggatgaagcctttcgcaagttcctgaagggcc 
               
               
                   
                   
                 tggcttcccgaaagccccttgtgctgtgtggaga 
               
               
                   
                   
                 cctcaatgtggcacatgaagaaattgaccttcgc 
               
               
                   
                   
                 aaccccaaggggaacaaaaagaatgctggcttca 
               
               
                   
                   
                 cgccacaagagcgccaaggcttcggggaattact 
               
               
                   
                   
                 gcaggctgtgccactggctgacagctttaggcac 
               
               
                   
                   
                 ctctaccccaacacaccctatgcctacacctttt 
               
               
                   
                   
                 ggacttatatgatgaatgctcgatccaagaatgt 
               
               
                   
                   
                 tggttggcgccttgattactttttgttgtcccac 
               
               
                   
                   
                 tctctgttacctgcattgtgtgacagcaagatcc 
               
               
                   
                   
                 gttccaaggccctcgcgagtgatcactgtcctat 
               
               
                   
                   
                 caccctatacctagcactgtgacaccacccctaa 
               
               
                   
                   
                 atcactttgagcctgggaaataagccccctcaac 
               
               
                   
                   
                 taccattccttctttaaacactcttcagagaaat 
               
               
                   
                   
                 ctgcattctatttctcatgtataaaacgaggaatcctccaaccaggct 
               
               
                   
                   
                 cctgtgataga 
               
               
                   
               
               
                 113 
                 210254_at 
                 Atacaccagcagggcaattagcagcttggggaagttggaa 
               
               
                   
                   
                 gtctcgatgttgtgatagtagaccacggaggtgacagcag 
               
               
                   
                   
                 ccatgaacgccatcccggctggcatgtacaggtgcagatg 
               
               
                   
                   
                 gtgggattcggtcaccccatcagacaggatgccctctgca 
               
               
                   
                   
                 atctcacacaccaggacgaagagcagcatgaaggtcagga 
               
               
                   
                   
                 tccaccgcaggttgtgcccngggaaatgaagccatgtgct 
               
               
                   
                   
                 gtggtggatgtgcaccttggagctctgacttccccatcca 
               
               
                   
                   
                 atgaagaggatggggaaggtgatgaagagtaggaagacgt 
               
               
                   
                   
                 gcggcaccacgttgagcgcgtccacaaagcagccgttgtt 
               
               
                   
                   
                 gaggaccc 
               
               
                   
               
               
                 114 
                 210338_s_at 
                 gaactgaatgctgacctgttccgtggcaccctggacccag 
               
               
                   
                   
                 tagagaaagcccttcgagatgccaaactagacaagtcaca 
               
               
                   
                   
                 gattcatgatattgtcctggttggtggttctactcgtatc 
               
               
                   
                   
                 cccaagattcagaagcttctccaagacttcttcaatggaa 
               
               
                   
                   
                 aagaactgaataagagcatcaaccctgatgaagctgttgc 
               
               
                   
                   
                 ttatggtgcagctgtccaggcagccatcttgtctggagac 
               
               
                   
                   
                 aagtctgagaatgttcaagatttgctgctcttggatgtca 
               
               
                   
                   
                 ctcctctttcccttggtattgaaactgctggtggagtcat 
               
               
                   
                   
                 gactgtcctcatcaagcgtaataccaccattcctaccaag 
               
               
                   
                   
                 cagacacagaccttcactacctattctgacaaccagcctg 
               
               
                   
                   
                 gtgtgcttattcag 
               
               
                   
               
               
                 115 
                 211038_s_at 
                 tggtgttccttgaatgcctatcttccttttgtgcctcgga 
               
               
                   
                   
                 acctctcacgcctgccacaagttactcttttccttggtag 
               
               
                   
                   
                 ttctaaactttaaataaggtaatgcctgtaagaatgccat 
               
               
                   
                   
                 aaatgctcaataattgtcatctgttattattttcatcagt 
               
               
                   
                   
                 aacatcatctgaatcatcagtattgtctgcttttaacagc 
               
               
                   
                   
                 tgcatttttcattgtccaaatatagtcacatacatttgac 
               
               
                   
                   
                 cattttataattattgaataataaattcgttctgctattt 
               
               
                   
                   
                 tacaatgaaaaataatgctgcagagagcatttttgcacat 
               
               
                   
                   
                 gtatcgtggcagatgtaggccagaggctcttctttatcca 
               
               
                   
                   
                 tcctatggccaacctatgaatgtatacacgtttaatgaga 
               
               
                   
                   
                 ttttgccagcaatcaaagccttcagggaaaatgtccctag 
               
               
                   
                   
                 ctctttactacatcagatcaagaactctggataattggca 
               
               
                   
                   
                 taacatcctggaatagctgaaacagagatattattctctg 
               
               
                   
                   
                 ctgtcctctgttgtctttgtcttttcacgtcttaata 
               
               
                   
               
               
                 116 
                 211458_s_at 
                 aaatagcattaaactggaattgacagagtgagttgagcat 
               
               
                   
                   
                 ctctgtctaacctgctctttctctctggtgctcctcatct 
               
               
                   
                   
                 cacccctaccttggaatttaataagcttcaggcatttcca 
               
               
                   
                   
                 attgcagactaaaaccacttctaccatctcctctagtatt 
               
               
                   
                   
                 ttccatgtatcaggacagagatgtcttatgtagggaaggg 
               
               
                   
                   
                 gcaggtatgaagtaaggtagattatctatacctctcactc 
               
               
                   
                   
                 attcaggattctcgctcccatgctgctgtcccttcattct 
               
               
                   
                   
                 cacactcacaggaatgctatgtgatggccagctgcttccc 
               
               
                   
                   
                 ttcttggttatccactgcagctgctagttagaaaggtttg 
               
               
                   
                   
                 cagggatgacttttagtaaatcatggggattttattgatt 
               
               
                   
                   
                 tattatcacttataggattttgtggggtgggagtggggag 
               
               
                   
                   
                 caggaattgcactcagacatgacatttcaattcatctctg 
               
               
                   
                   
                 caaatgaaaagggttcttcctcttgggggaaatctgtgtg 
               
               
                   
                   
                 tcagttctgtcagctgcaagttctt 
               
               
                   
               
               
                 117 
                 211560_s_at 
                 tccccatccgggtgggcaatgcagcactcaacagcaagct 
               
               
                   
                   
                 ctgtgatctcctgctctccaagcatggcatctatgtgcag 
               
               
                   
                   
                 gccatcaactacccaactgtcccccggggtgaagagctcc 
               
               
                   
                   
                 tgcgcttggcaccctccccccaccacagccctcagatgat 
               
               
                   
                   
                 ggaagattttgtggagaagctgctgctggcttggactgcg 
               
               
                   
                   
                 gtggggctgcccctccaggatgtgtctgtggctgcctgca 
               
               
                   
                   
                 atttctgtcgccgtcctgtacactttgagctcatgagtga 
               
               
                   
                   
                 gtgggaacgttcctacttcgggaacatggggccccagtat 
               
               
                   
                   
                 gtcaccacctatgcctgagaagccagctgcctaggattca 
               
               
                   
                   
                 caccccacctgcgcttcacttgggtccaggcctactcctg 
               
               
                   
                   
                 tcttctgctttgttgtgtgcctctagctgaattgagccta 
               
               
                   
                   
                 a 
               
               
                   
               
               
                 118 
                 211991_s_at 
                 Gcactgggaggcccaagagccaatccagatgcct 
               
               
                   
                   
                 gagacaacggagactgtgctctgtgccctgggcc 
               
               
                   
                   
                 tggtgctgggcctagtnggcatcatcgtgggcac 
               
               
                   
                   
                 cgtcctcatcataaagtctctgcgttctg 
               
               
                   
               
               
                 119 
                 212199_at 
                 attttgctgttacctttgtgacctgattgttttttggaac 
               
               
                   
                   
                 acgtcaagacgtgggatcagaatcttccaactttagaggt 
               
               
                   
                   
                 gcaatggaagacactacgctacttggttgagcctggtgaa 
               
               
                   
                   
                 gaatgtattaatgagactgctttgcataaaactgggaaga 
               
               
                   
                   
                 aagagaagacagttggagatggaagatggttttgtatata 
               
               
                   
                   
                 ttttggaactttagttcctctgtgagacgaaagaggagag 
               
               
                   
                   
                 ctatgttttgtgtcacattgtctgatatatattgtgtaac 
               
               
                   
                   
                 ctgtcaggtgagttgatttagacaacatagctgacctttt 
               
               
                   
                   
                 atgacaaggcagtttgaatagggactattgtaataccctc 
               
               
                   
                   
                 acacattatcggggcancagagaatggcatggaagagaca 
               
               
                   
                   
                 gtctacagagagctttaagaggccggagaaaggaaaagac 
               
               
                   
                   
                 attatcagggcctggaaagtctcttccagttcatcagggt 
               
               
                   
                   
                 ag 
               
               
                   
               
               
                 120 
                 212224_at 
                 Acagtgttctctaatgttacagatgagatgcgca 
               
               
                   
                   
                 ttgccaaagaggagatttttggaccagtgcagca 
               
               
                   
                   
                 aatcatgaagtttaaatctttagatgacgtgatc 
               
               
                   
                   
                 aaaagagcaaacaatactttctatggcttatcag 
               
               
                   
                   
                 caggagtgtttaccaaagacattgataaagccat 
               
               
                   
                   
                 aacaatctcctctgctctgcaggcaggaacagtg 
               
               
                   
                   
                 tgggtgaattgctatggcgtggtaagtgcccagt 
               
               
                   
                   
                 gcccctttggntgggattcaagatgtctggaaat 
               
               
                   
                   
                 ggaagagaactgggagagtacggtttccatgaat 
               
               
                   
                   
                 atacagaggtcaaaacagtcacagtgaaaatctc 
               
               
                   
                   
                 tcagaagaactcataaagaaaatacaagagtggagaga 
               
               
                   
                   
                 agctcttcaatagctaagcatctccttacagtcactaatat 
               
               
                   
               
               
                 121 
                 212232_at 
                 agaaggcagctctgcattctaccttgcttgactggaattg 
               
               
                   
                   
                 tctgaagctttttctggcctcttttctctagtcggccacc 
               
               
                   
                   
                 cctgaagtgctgaggtctaagtggtttacctcgtgctgat 
               
               
                   
                   
                 agatggccacactctttagagtagttctcataagttctag 
               
               
                   
                   
                 aactggtagctcggtcgtttcgcacactaggtggcataca 
               
               
                   
                   
                 ggcagcagcaggtgttcatatccttgattttgagaatttc 
               
               
                   
                   
                 ccctcaagtatgtggcagtaaatacaacaagacactctat 
               
               
                   
                   
                 gtattaatgtctccattgtcttaaccctgttccaaaacaa 
               
               
                   
                   
                 aattcacctcctttctttatgtg 
               
               
                   
               
               
                 122 
                 212534_at 
                 gtggattgtttgtatcccttacctgctttctattgggtta 
               
               
                   
                   
                 tgtgtggatatattgtttttatttgttcagcatctccttc 
               
               
                   
                   
                 cccatcttctggtaacacaacctttatttatttgtgggga 
               
               
                   
                   
                 acctattccctgtggcttaggtgagcatgtgaccaggcct 
               
               
                   
                   
                 ggcctcctgagtcccacagcttcctagccacagtgataaa 
               
               
                   
                   
                 agaatgggntatataacttaagccaggctaaggaaagccc 
               
               
                   
                   
                 ttaacagaacttctgctggaactactggaaagaaggcttt 
               
               
                   
                   
                 atggagatcccaggaaccaaggaccatgtaagcctgaatt 
               
               
                   
                   
                 tgtgccatgtggagagagtctgtctgaggagaaactcgga 
               
               
                   
                   
                 tgctagcagaaatggaaagagaactaagttctgatgtcat 
               
               
                   
                   
                 ttttctggaggccctagatccagctgt 
               
               
                   
               
               
                 123 
                 213142_x_at 
                 ctgctgccattttaatcttgctcattaaccttactccttt 
               
               
                   
                   
                 gagaattctttaacaatatttaaaattggtaacaaaaata 
               
               
                   
                   
                 gtttagccataattgtttagccatgtgagtttcaggttgg 
               
               
                   
                   
                 tacacgttcagacagaactgctgtatcacattccaatttt 
               
               
                   
                   
                 gaatagccagtgagcaatcaagtgtagagaaatgataaat 
               
               
                   
                   
                 ggcctaagaaggcatacagtggcataaacgatgctcttcc 
               
               
                   
                   
                 tagtagcttaataggccacaagctagtttctgttgcactc 
               
               
                   
                   
                 tgaaataaaatatgctttaaaaatgtagggaacagtgctt 
               
               
                   
                   
                 agaaaagcaaaaactaggtgtgtcattgaaataataggca 
               
               
                   
                   
                 taaaaattaaatgttacataagaacactatttggaaagag 
               
               
                   
                   
                 ggtccttttaaaaactgaatttgtactaaatcagatttgc 
               
               
                   
                   
                 catgtccagtacagaataatttgtacttagtatttgcagc 
               
               
                   
                   
                 agggtttgtctttgtga 
               
               
                   
               
               
                 124 
                 214433_s_at 
                 cttcctcggaggcagcattgttaagggaggccctgtgcaa 
               
               
                   
                   
                 gtgctggaggacgaggaactaaagtcccagccagagcccc 
               
               
                   
                   
                 tagtggtcaagggaaaacgggtggctggaggccctcagat 
               
               
                   
                   
                 gatccagctcagcctggatgggaagcgcctctacatcacc 
               
               
                   
                   
                 acgtcgctgtacagtgcctgggacaagcagttttaccctg 
               
               
                   
                   
                 atctcatcagggaaggctctgtgatgctgcaggttgatgt 
               
               
                   
                   
                 agacacagtaaaaggagggctgaagttgaaccccaacttc 
               
               
                   
                   
                 ctggtggacttcgggaaggagccccttggcccagcccttg 
               
               
                   
                   
                 cccnatgagctccgctaccctgggggcgattgtagctctg 
               
               
                   
                   
                 acatctggatttgaaggctccaccctcatcacccacactc 
               
               
                   
                   
                 cctattttgggccctcacttccttggggacctggcttcat 
               
               
                   
                   
                 tctgctctctcttggcacccgacccttggcagcatgtacc 
               
               
                   
                   
                 acacagccaagctgagactgtggcaatgtgttgagtcata 
               
               
                   
                   
                 tacatttactgaccactgttgct 
               
               
                   
               
               
                 125 
                 215933_s_at 
                 ggacagttcctgtgatcagaggcaagatttgcccagngaa 
               
               
                   
                   
                 cagaataaaggtgcttctttggatagctctcaatgttcgc 
               
               
                   
                   
                 cctcccctgcctcccaggaagaccttgaatcagagatttc 
               
               
                   
                   
                 agaggattctgatcaggaagtggacattgagggcgataaa 
               
               
                   
                   
                 agctattttaatgctggatgatgaccactggcattggcat 
               
               
                   
                   
                 gttcagaaaactggatttaggaataatgttttgctacaga 
               
               
                   
                   
                 aaatcttcatagaagaactggaaggctatataagaaaggg 
               
               
                   
                   
                 aatcaattctctggtattctggaaacctaaaaatatttgg 
               
               
                   
                   
                 tgcactgctcaattaacaaacctacatggagaccttaatt 
               
               
                   
                   
                 ttgacttaacaaatagtttatgtactgctcttaggttgtt 
               
               
                   
                   
                 ttgataaagtgacattatagtgattaaattctttccnctt 
               
               
                   
                   
                 taaaaaaacagntagtggttttcactatttataaatagga 
               
               
                   
                   
                 ccttcttgaacgacttttctg 
               
               
                   
               
               
                 126 
                 217478_s_at 
                 ctgttttgtcagtaatctcttcccacccatgctgacagtg 
               
               
                   
                   
                 aactggcagcatcattccgtccctgtggaaggatttgggc 
               
               
                   
                   
                 ctacttttgtctcagctgtcgatggactcagcttccaggc 
               
               
                   
                   
                 cttttcttacttaaacttcacaccagaaccttctgacatt 
               
               
                   
                   
                 ttctcctgcattgtgactcacgaaattgaccgctacacag 
               
               
                   
                   
                 caattgcctattgggtaccccggaacgcactgccctcaga 
               
               
                   
                   
                 tctgctggagaatgtgctgtgtggcgtggcctttggcctg 
               
               
                   
                   
                 ggtgtgctgggcatcatcgtgggcattgttctcatcatct 
               
               
                   
                   
                 acttccggaagccttgctcaggtgactgattcttccagac 
               
               
                   
                   
                 cagaatttgatgccagcagcttcagccatccaaacagagg 
               
               
                   
                   
                 atgctcagatttctcacatcctgc 
               
               
                   
               
               
                 127 
                 217736_s_at 
                 tctgtctggtcttcctctagaaggttctaccgcagaaatt 
               
               
                   
                   
                 gatgtgtgctccctgccctcgtcactgcccaagcccgggc 
               
               
                   
                   
                 ctgcacatactcactggactgttccagttttgacagctgc 
               
               
                   
                   
                 cagtcttcctgcccctttcacactgcagctgaagttcatt 
               
               
                   
                   
                 acctgaaggacgcctcatcatttcattccttggctccaaa 
               
               
                   
                   
                 ccttctgctgcctctaagataaaagctcaacttcttaaca 
               
               
                   
                   
                 gtgtacagtgtgcaacttccaacctttttatctgttctct 
               
               
                   
                   
                 ccaccttcagtttagcgtcattccaaaaccacacccttgc 
               
               
                   
                   
                 aaagctttgtactccgcaccccagatgatctccaggcagc 
               
               
                   
                   
                 tcagatctctttcctgcctttgccctgcactgttccccgg 
               
               
                   
                   
                 tacttcctcctttattgtagcactcagctccccagccaat 
               
               
                   
                   
                 ctgtacatccctcagaggcagcgatctgatgaattggttt 
               
               
                   
                   
                 ttgaatcccagaaacggtctgccatagagttcccagtcat 
               
               
                   
                   
                 cacggtagat 
               
               
                   
               
               
                 128 
                 219069_at 
                 gaatattgtatactgcatcccctaccacaatttacacaat 
               
               
                   
                   
                 cctgtggatagtcctacctcaccctggtcaacctacatga 
               
               
                   
                   
                 tccttaagctaatggcgaatcacgatgaccttgtagacat 
               
               
                   
                   
                 gcacacaactatacctttgtccaacagatcataatatatc 
               
               
                   
                   
                 tgctatccaactggttttacctgcctaatcctactgattt 
               
               
                   
                   
                 gggcactgcttgtatagtctctcaagttcacaggaaatgt 
               
               
                   
                   
                 tgattttctaaggtcctcattt 
               
               
                   
               
               
                 129 
                 219093_at 
                 tagagacccatgtcatcttaacctaaagggaaatcttatt 
               
               
                   
                   
                 gcgttatcataaaattgatgatatcttagggtcagaattg 
               
               
                   
                   
                 cccttttttttattttgaatgggaagctctcactaaaaca 
               
               
                   
                   
                 atcctgagatttcttaatttcatggttctttaaatattat 
               
               
                   
                   
                 aaacacagagtcaacatagaatgaaattgtatttgttaaa 
               
               
                   
                   
                 atacacacattggaggacaagagcagatgactacttttcg 
               
               
                   
                   
                 aagtaatgctgctccttcctaaaagtctgttttcaatcct 
               
               
                   
                   
                 ggtaatattaggggcactgcggcacctaagaagccttaaa 
               
               
                   
                   
                 tgagagctaatccaatttagagagcgatggtgtcagcatt 
               
               
                   
                   
                 tcggtctgcatatctgtgtgtccgtatctgcgtttgtgtg 
               
               
                   
                   
                 cgtgtacgtgtgcccctgtgtgtgggcccagttttcaggc 
               
               
                   
                   
                 atgtagaataagcatggagtcatattgaggaggactcact 
               
               
                   
                   
                 tcttgaagat 
               
               
                   
               
               
                 130 
                 219228_at 
                 ggggttcgagcctcgttaagcacgagaggatacatacggg 
               
               
                   
                   
                 cgagaagccgtacaagtgcacagaatgtgggaaggccttc 
               
               
                   
                   
                 aattgtggctatcacctcactcagcacgagagaatccaca 
               
               
                   
                   
                 caggcgaaaccccgtataaatgtaaggagtgtgggaaggc 
               
               
                   
                   
                 tttcatttatggatcgagcctcgtgaaacatgagagaatt 
               
               
                   
                   
                 cataccggggtgaaaccctatgggtgtacagaatgtggga 
               
               
                   
                   
                 agagctttagtcacggccatcagcttacacaacatcagaa 
               
               
                   
                   
                 aacgcacagtggggcgaaatcctacgaatgtaaggagtgc 
               
               
                   
                   
                 gggaaggcatgtaaccacctaaaccatctccgagaacatc 
               
               
                   
                   
                 agaggatccacaacagttgaagagccttttgaacgcagta 
               
               
                   
                   
                 gcccgctcgtatctatggtttcgctttccacagtttgtta 
               
               
                   
                   
                 cctgca 
               
               
                   
               
               
                 131 
                 219607_s_at 
                 atcaacacatttagcttggcgttttattcattccatcacc 
               
               
                   
                   
                 cttactgtaactactatggcaactcaaataattgtcatgg 
               
               
                   
                   
                 gactatgtccatcttaatgggtctggatggcatggtgctc 
               
               
                   
                   
                 ctcttaagtgtgctggaattctgcattgctgtgtccctct 
               
               
                   
                   
                 ctgcctttggatgtaaagtgctctgttgtacccctggtgg 
               
               
                   
                   
                 ggttgtgttaattctgccatcacattctcacatggcagaa 
               
               
                   
                   
                 acagcatctcccacaccacttaatgaggtttgaggccacc 
               
               
                   
                   
                 caaagatcaacagacaaatgctccagaaatctatgctgac 
               
               
                   
                   
                 tgtgacacaag 
               
               
                   
               
               
                 132 
                 221748_s_at 
                 atattttgtatcatcgtgcctatagccgctgccaccgtgt 
               
               
                   
                   
                 ataaatcctggtgtntgctccttatcctggacatgaatgt 
               
               
                   
                   
                 attgtacactgacgcgtccccactcctgtacagctgcttt 
               
               
                   
                   
                 gtttctttgcaatgcattgtatggcttta 
               
               
                   
               
               
                 133 
                 221766_s_at 
                 gatttccaggaagcctttgatcacctttgtaacaagatca 
               
               
                   
                   
                 ttgccaccaggaacccagaggaaatccgagggggaggcct 
               
               
                   
                   
                 gcttaagtactgcaacctcttggtgaggggctttaggccn 
               
               
                   
                   
                 gcctctgatgaaatcaagacccttcaaaggtatatgtgtt 
               
               
                   
                   
                 ccaggtttttcatcgacttctcagacattggagagcagca 
               
               
                   
                   
                 gagaaaactggagtcctatttgcagaaccactttgtggga 
               
               
                   
                   
                 ttggaagaccgcaagtatgagtatctcatgacccttcatg 
               
               
                   
                   
                 gagtggtaaatgagagcacagtgtgccntgatgggacatg 
               
               
                   
                   
                 aaagaagacagactttaaaccttatcaccatgctggctat 
               
               
                   
                   
                 ccgggtgttagctgaccaaaatgtcattcctaatgtggct 
               
               
                   
                   
                 aatgtcacttgctattaccagccagccccctatgtagcag 
               
               
                   
                   
                 atgccaactttagcaattactacattgcacaggttcagcc 
               
               
                   
                   
                 agtattcacgtgccagcaacagacctactccacttggcta 
               
               
                   
                   
                 ccctgcaattaaga 
               
               
                   
               
               
                 134 
                 221622_s_at 
                 atgcatcattggctacacttccatttttgtctactgttgt 
               
               
                   
                   
                 tactgacaagctttttgtaattgatgctttgtattcagat 
               
               
                   
                   
                 aatataagcaaggaaaactgtgttttcagaagctcactga 
               
               
                   
                   
                 ttggcatagtttgtggtgttttctatcccagttctttggc 
               
               
                   
                   
                 ttttactaaaaatggacgcctggcaaccaagtatcatacc 
               
               
                   
                   
                 gttccactgccaccaaaaggaagggttttaatccattgga 
               
               
                   
                   
                 tgacgctttgtcaaacacaaatgaaattaattgcgattcc 
               
               
                   
                   
                 tctagtctttcagattatgtttggaatattaaatggctat 
               
               
                   
                   
                 accattatgcaagtatttgaaagagacacttgagaaaact 
               
               
                   
                   
                 atacatgaagagtaaccaaaaaaatgaatggttgctaact 
               
               
                   
                   
                 tagcaaaatgaagtttctataaagaggactcaggcattgc 
               
               
                   
                   
                 tgaaagagttaaaagtaactgtgaacaaataatttgttct 
               
               
                   
                   
                 gtgccttttgcctggtatatagc 
               
               
                   
               
               
                 135 
                 218845_at 
                 aaaacattctggccgctccaggaattctgaagttctgggc 
               
               
                   
                   
                 ctttctcagaagactgtaatgtacctgaagtttctgaaat 
               
               
                   
                   
                 attgcaaacccacagagtttaggctggtgctgccaaaaag 
               
               
                   
                   
                 aaaagcaacatagagtttaagtatccagtagtgatttgta 
               
               
                   
                   
                 aacttgtttttcatttgaagctgaatatatacgtagtcat 
               
               
                   
                   
                 gtttatgttgagaactaaggatattctttagcaagagaaa 
               
               
                   
                   
                 atattttccccttatccccactgctgtggaggtttctgta 
               
               
                   
                   
                 cctcgcttggatgcctgtaaggatcccgggagccttgccg 
               
               
                   
                   
                 cactgccttgtgggtggcttggcgctcgtgattgcttcct 
               
               
                   
                   
                 gtgaacgcctcccaaggacgagcccagtgtagttgtgtgg 
               
               
                   
                   
                 gcgtgaactctgcccgtgtgttctcaaattccccagcttg 
               
               
                   
                   
                 ggaaatagcccttggtgtgggttttatctctggtttgtgt 
               
               
                   
                   
                 tctccgtggtggaattgaccgaaagctctatgttt 
               
               
                   
               
               
                 136 
                 200786_at 
                 gttacattggtgcagccctagttttagggggagtagatgt 
               
               
                   
                   
                 tactggacctcacctctacagcatctatcctcatggatca 
               
               
                   
                   
                 actgataagttgccttatgtcaccatgggttctggctcct 
               
               
                   
                   
                 tggcagcaatggctgtatttgaagataagtttaggccaga 
               
               
                   
                   
                 catggaggaggaggaagccaagaatctggtgagcgaagcc 
               
               
                   
                   
                 atcgcagctggcatcttcaacgacctgggctccggaagca 
               
               
                   
                   
                 acattgacctctgcgtcatcagcaagaacaagctggattt 
               
               
                   
                   
                 tctccgcccatacacagtgcccaacaagaaggggaccagg 
               
               
                   
                   
                 cttggccggtacaggtgtgagaaagggactactgcagtcc 
               
               
                   
                   
                 tcactgagaaaatcactcctctggagattgaggtgctgga 
               
               
                   
                   
                 agaaacagtccaaacaatggacacttcctgaatggcatca 
               
               
                   
                   
                 gtgggtggctggccgcggttctggaaggtggtgagcattg 
               
               
                   
                   
                 aggcccagtaagacactcatgtgg 
               
               
                   
               
               
                 137 
                 212886_at 
                 acaggcacatcaggctgcagaatgcgctttagaaagcatt 
               
               
                   
                   
                 gttttagtccaggcacagtggctcacgcctgtaatcccag 
               
               
                   
                   
                 cactttgggaggccgaggtgggtggatcacaaggttggga 
               
               
                   
                   
                 gattgagaccatcctggctaacacagtgaaaccctgtctc 
               
               
                   
                   
                 tactaaaaaaatacaaaaaattagcttggcgtggtggtgg 
               
               
                   
                   
                 gcgcctgtagtcccagcagcttgggaggctgaggctggag 
               
               
                   
                   
                 aatggtgtgaacccaggaggcggagcttgcagtgagccaa 
               
               
                   
                   
                 gatcgcgccactgcactccagcccgggtgacagagcaaga 
               
               
                   
                   
                 ctccgtctcaaaaaaaagaaaagaaaaaagaaagcattgt 
               
               
                   
                   
                 tttaattgagaggggcagggctggagaaggagcaagttgt 
               
               
                   
                   
                 ggggagccaggcttccctcacgcagcctgtggtggatgtg 
               
               
                   
                   
                 ggaaggagatcaacttctcctcactctgggacagacgatg 
               
               
                   
                   
                 tatggaaactaa 
               
               
                   
               
               
                 138 
                 201407_s_at 
                 ggatgtgattctaaaagcttttattgagcattgtcaaatt 
               
               
                   
                   
                 tgtaagcttcatagggatggacatcatatctataatgccc 
               
               
                   
                   
                 ttctatatgtgctaccatagatgtgacatttttgacctta 
               
               
                   
                   
                 atatcgtctttgaaaatgttaaattgagaaacctgttaac 
               
               
                   
                   
                 ttacattttatgnattggcacattgtattacttactgcaa 
               
               
                   
                   
                 gagatatttcattttcagcacagtgcaaaagttctttaaa 
               
               
                   
                   
                 atgcatatgtctttttttctaattccgttttgttttaaag 
               
               
                   
                   
                 cacattttaaatgtagttttctcatttagtaaaagt 
               
               
                   
               
               
                 139 
                 212266_s_at 
                 gttgagtttgcctcttatggtgacttaaagaatgctattg 
               
               
                   
                   
                 aaaaactttctggaaaggaaataaatgggagaaaaataaa 
               
               
                   
                   
                 attaattgaaggcagcaaaaggcacagtaggtcaagaagc 
               
               
                   
                   
                 aggtctcgatcccggaccagaagttcctctaggtctcgta 
               
               
                   
                   
                 gccgatcccgttcccgtagtcgcaaatcttacagccggtc 
               
               
                   
                   
                 aagaagcaggagcaggagccggagccggagcaagtcccgt 
               
               
                   
                   
                 tctgttagtaggtctcccgtgcctgagaagagccagaaac 
               
               
                   
                   
                 gtggttcttcaagtagatctaagtctccagcatctgtgga 
               
               
                   
                   
                 tcgccagaggtcccggtcccgatcaaggtccagatcagtt 
               
               
                   
                   
                 gacagtggcaattaaactgtaaataacttgccctgggggc 
               
               
                   
                   
                 ctttttttaaaaaacaaaaaccacaaaaattcccaaacca 
               
               
                   
                   
                 tacttgctaaaaattctggtaagtatgtgcttttctgtgg 
               
               
                   
                   
                 gggtgggatttggaaggggggttgggttgggctggatatc 
               
               
                   
                   
                 tttgt 
               
               
                   
               
               
                 140 
                 53912_at 
                 acaatgaggcattctgtcctcctgctgccattcttcatct 
               
               
                   
                   
                 ccactgagagccagagctggtaggagccgagnnnccacag 
               
               
                   
                   
                 gcattctgcattgctctactcttaggtttgtgtgtgtgat 
               
               
                   
                   
                 ccttcccctccctgtcgcccactcctccctcctctggcta 
               
               
                   
                   
                 tcctaccctgtctgtgggctcttttactaccagcctatgc 
               
               
                   
                   
                 tgtgggactgtcatggcatttagttcagagtggaggggnn 
               
               
                   
                   
                 nnnnnnnnnnnnnaaatgcaagtatttnannnnnnnnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnnnnaanattgttgttgca 
               
               
                   
                   
                 atttgtgtctaacaagctgtagcagagaaggagggagtga 
               
               
                   
                   
                 gcgctggcagtatttcctttcataaatcatgaatttatca 
               
               
                   
                   
                 gtgtggaaataatgcttcagaactgtgctctgtagccctc 
               
               
                   
                   
                 ctgcannnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 
               
               
                   
                   
                 nnnnnngcgtgaaccttgttaggtatactttacctgatgc 
               
               
                   
                   
                 tgcttccatcctcgcagtctg 
               
               
                   
               
               
                 141 
                 200090_at 
                 tccctttgcctgtggtgtaaaagtgcatcacacaggtatt 
               
               
                   
                   
                 gctttttaacaagaactgatgctccttgggtgctgctgct 
               
               
                   
                   
                 actcagactagctctaagtaatgtgattcttctaaagcaa 
               
               
                   
                   
                 agtcattggatgggaggaggaagaaaaagtcccataaagg 
               
               
                   
                   
                 aacttttgtagtcttatcaacatataatctaatcccttag 
               
               
                   
                   
                 catcagctcctccctcagtggtacatgcgtcaagatttgt 
               
               
                   
                   
                 agcagtaataactgcaggtcacttgtatgtaatggatgtg 
               
               
                   
                   
                 aggtagccgaagtttggttcagtaagcagggaatacagtc 
               
               
                   
                   
                 gttccatcagagctggtctgcacactcacattatcttgct 
               
               
                   
                   
                 atcactgtaaccaacta 
               
               
                   
               
               
                 142 
                 218025_s_at 
                 ctccttgggctattcgatgccgtgtatgcatctgacaggg 
               
               
                   
                   
                 caacatttcatacaccatttagtcacctaggccaaagtcc 
               
               
                   
                   
                 ggaaggatgctcctcttacacttttccgaagataatgagc 
               
               
                   
                   
                 ccagccaaggcaacagagatgcttatttttggaaagaagt 
               
               
                   
                   
                 taacagcgggagaggcatgtgctcaaggacttgttactga 
               
               
                   
                   
                 agttttccctgatagcacttttcagaaagaagtctggacc 
               
               
                   
                   
                 aggctgaaggcatttgcaaagcttcccccaaatgccttga 
               
               
                   
                   
                 gaatttcaaaagaggtaatcaggaaaagagagagagaaaa 
               
               
                   
                   
                 actacacgctgttaatgctgaagaatgcaatgtccttcag 
               
               
                   
                   
                 ggaagatggctatcagatgaatgcacaaatgctgtggtga 
               
               
                   
                   
                 acttcttatccagaaaatcaaaactgtgatgaccactaca 
               
               
                   
                   
                 gcagagtaaagcatgtccaaggaaggatgtgctgttacct 
               
               
                   
                   
                 ctgatttccagtac 
               
               
                   
               
               
                 143 
                 204232_at 
                 cgatctccagcccaagatgattccagcagtggtcttgctc 
               
               
                   
                   
                 ttactccttttggttgaacaagcagcggccctgggagagc 
               
               
                   
                   
                 ctcagctctgctatatcctggatgccatcctgtttctgta 
               
               
                   
                   
                 tggaattgtcctcaccctcctctactgtcgactgaagatc 
               
               
                   
                   
                 caagtgcgaaaggcagctataaccagctatgagaaatcag 
               
               
                   
                   
                 atggtgtttacacgggcctgagcaccaggaaccaggagac 
               
               
                   
                   
                 ttacgagactctgaagcatgagaaaccaccacagtagctt 
               
               
                   
                   
                 tagaatagatgcggtcatattcttctttggcttctggttc 
               
               
                   
                   
                 ttccagccctcatggttggcatcacatatgcctgcatgcc 
               
               
                   
                   
                 attaacaccagctggccctacccctataatgatcctgtgt 
               
               
                   
                   
                 cctaaattaatatacaccagtggttcctcctccctgttaa 
               
               
                   
                   
                 agactaatgctcagatgctgtttacggatatttatattct 
               
               
                   
                   
                 agtctcactctcttgtcccacccttcttctcttccccatt 
               
               
                   
                   
                 cccaactccagctaaaatat 
               
               
                   
               
               
                 144 
                 201722_s_at 
                 attttgttttcatctgtgatagtcatggatgcttttattt 
               
               
                   
                   
                 tccttggggtgctgaaattgagctgaaaaaaaaaggctct 
               
               
                   
                   
                 ttgaatatagttttaatttctctctacagttttttttgtt 
               
               
                   
                   
                 tggtttgtgggctgttggaattgtaatttttaattgcctt 
               
               
                   
                   
                 ctaaaaaatggaaatttaacaatgtctgatctcagctgaa 
               
               
                   
                   
                 caaattagatgtttcagttgctcttgggtcaactggctta 
               
               
                   
                   
                 cagatttacatgtgcacacacacacaaatttcttatcaca 
               
               
                   
                   
                 ttttcgacttcttcacttgacctaactgattatgcgaaat 
               
               
                   
                   
                 acccaagattcatgctactgtaccacagatttgttttcac 
               
               
                   
                   
                 agcaataaatcttcagttctgttgtttatgattccactta 
               
               
                   
                   
                 acaaaaggcctgcagaagtgatttattatttgggtatttg 
               
               
                   
                   
                 gagataatacatttgatggttttttggaaaacctttttca 
               
               
                   
                   
                 ctccatactcagatatgcttcattgtcaaatgcatattta 
               
               
                   
                   
                 gattagattattgaattgtaatgtttatctgctgctttt 
               
               
                   
               
               
                 145 
                 218627_at 
                 taatcatttctgggttcactgcgactcactgtagtgctgg 
               
               
                   
                   
                 ggatcccccttgtaacactggaactgaaaggcagtgatga 
               
               
                   
                   
                 aagctatgtcaagcattcattattctgaagaggaggagaa 
               
               
                   
                   
                 atgccacatacctttcccatgggacctgtggtggaatgaa 
               
               
                   
                   
                 tccatacttctgcctcacttcgagcagacttttgttctcg 
               
               
                   
                   
                 gcgctcctcacgatggagtttcatgcttcattttcacatc 
               
               
                   
                   
                 tctctgcacaattagattgggagctccttgagggcagagt 
               
               
                   
                   
                 acgtgccttaatctttatctttgtaatgccaccatgaaca 
               
               
                   
                   
                 gagtgcctcctggtacactgtaggagcttaagaaatactc 
               
               
                   
                   
                 actgaatgcatgaatgaatgaatgaacaaatgaaggaatg 
               
               
                   
                   
                 actaaggatgtttgtagtgctataatatagaatgggattt 
               
               
                   
                   
                 actctgctttacc 
               
               
                   
               
               
                 146 
                 202322_s_at 
                 gttctcatttcctactattcatgctatttggtcaaggcct 
               
               
                   
                   
                 gaaagcacccaggtgcagaatatcttgcgccagagaacag 
               
               
                   
                   
                 aaaacatagatataaaaaaatactgtgtacattatcttga 
               
               
                   
                   
                 ggatgtaggttcttttgaatacactcgtaatacccttaaa 
               
               
                   
                   
                 gagcttgaagctaaagcctataaacagattgatgcacgtg 
               
               
                   
                   
                 gtgggaaccctgagctagtagccttagtaaaacacttaag 
               
               
                   
                   
                 taagatgttcaaagaagaaaatgaataatgttaagccatt 
               
               
                   
                   
                 cttgattggacctcatagcttattttagttaatctttttt 
               
               
                   
                   
                 ttgtcttttagccttaccaccttttaaaaaatttgttatt 
               
               
                   
                   
                 ctccagaaacagtaaataggtgagtaggggtggtgcaagt 
               
               
                   
                   
                 gaattcgttttcatttagaagcccctctgtacagataatc 
               
               
                   
                   
                 aaaattcaaagttgaaagaatcaaaagcagccacagttat 
               
               
                   
                   
                 gtaggtctgatttgaatgtcataattgcagtgacaggaca 
               
               
                   
                   
                 ttgccaccaactctatcctactaccatcaatgt 
               
               
                   
               
               
                 147 
                 221689_s_at 
                 Accgtcgccattgccagaaagagcgatttatggctttgtt 
               
               
                   
                   
                 cttttcttaagctcccaatttggcttcatactttacctcg 
               
               
                   
                   
                 tgtgggcctttattcctgaatcttggctaaactctttagg 
               
               
                   
                   
                 tttaacctattggcctcaaaaatattgggcagttgcatta 
               
               
                   
                   
                 cctgtctacctccttattgctatagtaattggctacgtgc 
               
               
                   
                   
                 tcttgtttgggattaacatgatgagtacctctccactcga 
               
               
                   
                   
                 ctccatccatacaatcacagataactatgcaaaaaatcaa 
               
               
                   
                   
                 cagcagaagaaataccaagaggaggccattccagccttaa 
               
               
                   
                   
                 gagatatttctattagtgaagtaaaccaaatgttctttct 
               
               
                   
                   
                 tgcagccaaagaactttacaccaaaaactgaactgtgtgt 
               
               
                   
                   
                 aaccatagtaacaccaagcacgtatttatttataagtttt 
               
               
                   
                   
                 tgccattataattttgaccataaattaatttaaccatctc 
               
               
                   
                   
                 tcttattaatagagaagtaaaaaatgtaagttgaccttct 
               
               
                   
                   
                 cttagattat 
               
               
                   
               
               
                 148 
                 203356_at 
                 tatacatcttgggcaactagttaccaaatgaattgtgcca 
               
               
                   
                   
                 ccataactgattttaattttgcattatttatgattttaaa 
               
               
                   
                   
                 atatttgttgcccaggtgttatgaaagaataaagctttta 
               
               
                   
                   
                 agtatagactaccttagcatgaagatgctcatgcctaaga 
               
               
                   
                   
                 atgaaaattgttgaggttatctcccattcaatcatgtagc 
               
               
                   
                   
                 aagaacttaaagaaattcactactgcagtttttattttta 
               
               
                   
                   
                 aaaaacagtaattgagatattgaagacattacaatttagt 
               
               
                   
                   
                 ttgtgtggtctttttttaaattgctgtatcgttcagtctc 
               
               
                   
                   
                 ttgtggcaatagcactttgaagaaaatagagaatttaata 
               
               
                   
                   
                 tatggtgattgggatatgtagcattcaaaaaaagtgaatt 
               
               
                   
                   
                 gccaagatactggtgtcatgtaaattcccactttacataa 
               
               
                   
                   
                 aaacccatcaggacagaatgatgctcaatattttaaaatt 
               
               
                   
                   
                 ctaaaaatagggtgggatttttcattgtctctactttata 
               
               
                   
                   
                 attatcaaaacttattttgtattgctactaccttaaattg 
               
               
                   
                   
                 aaa 
               
               
                   
               
               
                 149 
                 218462_at 
                 aaatgagcagtgttcgtcttcgtaaagaaattaagagaag 
               
               
                   
                   
                 aggcaaggaccccacagaacacatacctgaaataattctg 
               
               
                   
                   
                 aataattttacaacacggctgggtcattcaattggacgta 
               
               
                   
                   
                 tgtttgcatctctctttcctcataatcctcaatttatcgg 
               
               
                   
                   
                 aaggcaggttgccacattccacaatcaacgggattacata 
               
               
                   
                   
                 ttcttcagatttcacagatacatattcaggagtgaaaaga 
               
               
                   
                   
                 aagtgggaattcaggaacttggaccacgttttaccttaaa 
               
               
                   
                   
                 attaaggtctcttcagaaaggaacctttgattctaaatat 
               
               
                   
                   
                 ggagagtatgaatgggtccataagccccgggaaatggata 
               
               
                   
                   
                 caagtagaagaaaattccatttataaagtactgagagaat 
               
               
                   
                   
                 gatattggattttgctgaacaggcctatcttgaactttgg 
               
               
                   
                   
                 taaattatttttgacagaatactcttttcaaaatggcatt 
               
               
                   
                   
                 tgctgatttcataaacctttcacgtctggacgaattacca 
               
               
                   
                   
                 aatgccatgaattgccactgtgtg 
               
               
                   
               
               
                 150 
                 218123_at 
                 gtggaagccggtgtctgtgttaccatggagatggtgaaag 
               
               
                   
                   
                 atgccttggaccagcttcgaggcgcggtgatgattgttta 
               
               
                   
                   
                 ccccatggggttgccaccgtatgatcccatccgcatggag 
               
               
                   
                   
                 tttgaaaataaggaagacttgtcgggaacacaggcagggc 
               
               
                   
                   
                 tcaacgtcattaaagaggcagaggcgcagctgtggtgggc 
               
               
                   
                   
                 agccaaggagctgagaagaacgaagaagctttcagactac 
               
               
                   
                   
                 gtggggaagaatgaaaaaaccaaaattatcgccaagattc 
               
               
                   
                   
                 agcaaaggggacagggagctccagcccgagagcctattat 
               
               
                   
                   
                 tagcagtgaggagcagaagcagctgatgctgtactatcac 
               
               
                   
                   
                 agaagacaagaggagctcaagagattggaagaaaatgatg 
               
               
                   
                   
                 atgatgcctatttaaactcaccatgggcggataacactgc 
               
               
                   
                   
                 tttgaaaagacattttcatggagtgaaagacataaagtgg 
               
               
                   
                   
                 agaccaagatgaagttcaccagctgatgacacttccaaa 
               
               
                   
               
               
                 151 
                 214329_x_at 
                 aggttgcagtgtggtgagatcatgccactacactccagcc 
               
               
                   
                   
                 tggcgacagagcgagacttggtttcnaaaaaaaaaaaaaa 
               
               
                   
                   
                 aaaaacttcagtaagtacgtgttatttttttcaataaaat 
               
               
                   
                   
                 tctattacagtatgtcatgtttgctgtagtgctcatattt 
               
               
                   
                   
                 attgttgtttttgttttagtactcacttgtttcataatat 
               
               
                   
                   
                 caagattactaaaaatgggggaaaggacttctaatctttt 
               
               
                   
                   
                 tttcataatatctttgacacatattacagaag 
               
               
                   
               
               
                 152 
                 219067_s_at 
                 cgagaagatcctgataccccaatgtccttctttgactttg 
               
               
                   
                   
                 tggttgatcctcattctttcccccgtacagtggaaaacat 
               
               
                   
                   
                 ctttcatgtttccttcattatacgggatggttttgcaaga 
               
               
                   
                   
                 ataagacttgaccaagaccgactgccagtaatagagcctg 
               
               
                   
                   
                 ttagtattaatgaagaaaatgagggatttgaacataacac 
               
               
                   
                   
                 acaagttagaaatcaaggaattatagctttgagttaccgt 
               
               
                   
                   
                 gactgggaggagattgtgaagacctttgagatttcagagc 
               
               
                   
                   
                 ctgtgattactccaagtcagaggcagcagaagccaagtgc 
               
               
                   
                   
                 ttgatgctagctgaaggactcaaatggatagtgaagtcca 
               
               
                   
                   
                 aaacggaaagcggcatgtattgtaca 
               
               
                   
               
               
                 153 
                 205789_at 
                 gtcatgaggcagctttcatcacacccttttaacatttatc 
               
               
                   
                   
                 taaaagaatttaaattctttttcaaaaattacactacaag 
               
               
                   
                   
                 tttataagcccaaatggctctgtgaaatcagaagtgcaaa 
               
               
                   
                   
                 ggtgtgcaaacttgtatctgaagacctaccagggacaagc 
               
               
                   
                   
                 aggtaagagctgatgtgagtgtgtgtgatgggatctgtaa 
               
               
                   
                   
                 ggaactggaacacacatgtcctatccaaaggaatcagctg 
               
               
                   
                   
                 cagctgcttgttgtcaagtataaagtcaggacctggcttg 
               
               
                   
                   
                 gctttaaccgtttttcaagaaaactggaaatctggatttt 
               
               
                   
                   
                 cagcgaacatgcctgattttaaaaggttgactcaagtttt 
               
               
                   
                   
                 tacaaaatactatgtgggacacctcaaatacatacctact 
               
               
                   
                   
                 gactgatgacaaacccaggagtttgtgtgtcttttataaa 
               
               
                   
                   
                 aagtttgccctggatgtcatat 
               
               
                   
               
               
                 154 
                 209214_s_at 
                 cagtgtcccaatccgggttgtggaaaccagaacttcgcct 
               
               
                   
                   
                 ggagaacagagtgcaaccagtgtaaggccccaaagcctga 
               
               
                   
                   
                 aggcttcctcccgccaccctttccgcccccgggtggtgat 
               
               
                   
                   
                 cgtggcagaggtggccctggtggcatgcggggaggaagag 
               
               
                   
                   
                 gtggcctcatggatcgtggtggtcccggtggaatgttcag 
               
               
                   
                   
                 aggtggccgtggtggagacagaggtggcttccgtggtggc 
               
               
                   
                   
                 cggggcatggaccgaggtggctttggtggaggaagacgag 
               
               
                   
                   
                 gtggccctggggggccccctggacctttgatggaacagat 
               
               
                   
                   
                 gggaggaagaagaggaggacgtggaggacctggaaaaatg 
               
               
                   
                   
                 gataaaggcgagcaccgtcaggagcgcagagatcggccct 
               
               
                   
                   
                 actagatgcagagaccccgcagagctgcattgactaccag 
               
               
                   
                   
                 atttattttttaaaccagaaaatgttttaaatttataatt 
               
               
                   
                   
                 ccatatttataatgttggccacaacattatgattattcct 
               
               
                   
                   
                 tgtctgtactttagtatttttcacca 
               
               
                   
               
               
                 155 
                 213427_at 
                 cgttgagagatctccagtgcccagtgctgcagagcagcga 
               
               
                   
                   
                 gctggagggaacgccagaggtgtcctgccgggctctggag 
               
               
                   
                   
                 ctcttcgactggctcggcgccgtcttcagtaatgtcgacc 
               
               
                   
                   
                 taaataatgagcctaataatttcatatcaacctattgctg 
               
               
                   
                   
                 tcctgagccaagcacagtggtggcaaaagcttatttgtgt 
               
               
                   
                   
                 acaatcactggcttcatacttccagagaagatctgtctcc 
               
               
                   
                   
                 tattggaacatctctgtcactactttgatgaaccgaagtt 
               
               
                   
                   
                 agctccatgggttacactgtccgttcaaggctttgcagac 
               
               
                   
                   
                 agccctgtttcttgggaaaaaaatgaacatggttttcgaa 
               
               
                   
                   
                 aaggaggagaacatttatataactttgtgatttttaataa 
               
               
                   
                   
                 tcaggactattggcttcagatggctgtt 
               
               
                   
               
               
                 156 
                 209422_at 
                 Cagctcgggcgacaactgcaagactccatctcaaaaaaat 
               
               
                   
                   
                 aaaaataaaagaaaagaaagaaatatgtgcactacctaag 
               
               
                   
                   
                 ttttgtctttagaaaaactatccacctataaaaaattacc 
               
               
                   
                   
                 ttgacaaaaatagttccggtttgactaatcattttgtttc 
               
               
                   
                   
                 tttaagtggtaagtgtatgcaaggtggatccttgatgagc 
               
               
                   
                   
                 caacattgcactgtggatacatatctatgtttacgcgcta 
               
               
                   
                   
                 ttagaacagaaggcgctgtatatagaaatgttgctttgaa 
               
               
                   
                   
                 gcaatatttgcaaaacacgcagacttctgtatctg 
               
               
                   
               
               
                 157 
                 201010_s_at 
                 gtgttctcctactgcaaatattttcatatgggaggatggt 
               
               
                   
                   
                 tttctcttcatgtaagtccttggaattgattctaaggtga 
               
               
                   
                   
                 tgttcttagcactttaattcctgtcaaattttttgttctc 
               
               
                   
                   
                 cccttctgccatcttaaatgtaagctgaaactggtctact 
               
               
                   
                   
                 gtgtctctagggttaagccaaaagacaaaaaaaattttac 
               
               
                   
                   
                 tacttttgagattgccccaatgtacagaattatataattc 
               
               
                   
                   
                 taacgcttaaatcatgtgaaagggttgctgctgtcagcct 
               
               
                   
                   
                 tgcccactgtgacttcaaacccaaggaggaactcttgatc 
               
               
                   
                   
                 aagatgcccaaccctgtgatcagaacctccaaatactgcc 
               
               
                   
                   
                 atgagaaactagagggcaggtgttcataaaagccctttga 
               
               
                   
                   
                 acccccttcctgccctgtgttaggagatagggatattggc 
               
               
                   
                   
                 ccctcactgcagctgccagcacttggtcagtcactctcag 
               
               
                   
                   
                 ccatagcactttgttcactgtcctgtgtcagagcactgag 
               
               
                   
                   
                 ctccacccttttctgagagttat 
               
               
                   
               
               
                 158 
                 200883_at 
                 ttgccaaggcaactcagcagccatttgatgtttctgcatt 
               
               
                   
                   
                 taatgccagttactcagattctggactctttgggatttat 
               
               
                   
                   
                 actatctcccaggccacagctgctggagatgttatcaagg 
               
               
                   
                   
                 ctgcctataatcaagtaaaaagaatagctcaaggaaacct 
               
               
                   
                   
                 ttccaacacagatgtccaagc 
               
               
                   
               
               
                 159 
                 218454_at 
                 gtggctatccactgttagttcagaagctgggcttggacta 
               
               
                   
                   
                 ctcttatgatttagctccacgagccaaaattttccggcgt 
               
               
                   
                   
                 gaccaagggaaagtgactgatacggcatccatgaaatata 
               
               
                   
                   
                 tcatgcgatacaacaattataagaaggatccttacagtag 
               
               
                   
                   
                 aggtgacccctgtaataccatctgctgccgtgaggacctg 
               
               
                   
                   
                 aactcacctaacccaagtcctggaggttgttatgacacaa 
               
               
                   
                   
                 aggtggcagatatctacctagcatctcagtacacatccta 
               
               
                   
                   
                 tgccataagtggtcccacagtacaaggtggcctccctgtt 
               
               
                   
                   
                 tttcgctgggaccgtttcaacaaaactctacatcagggca 
               
               
                   
                   
                 tgccagaggtctacaactttgattttattaccatgaaacc 
               
               
                   
                   
                 aattttgaaacttgatataaaatgaaggagggagatgacg 
               
               
                   
                   
                 gactagaagactgtaaataagataccaaaggcactatttt 
               
               
                   
                   
                 agctatgtttttcccatcagaat 
               
               
                   
               
               
                 160 
                 202918_s_at 
                 gagtgtcctgctatagactatactagacacacacttgatg 
               
               
                   
                   
                 gtgctgcatgtcttctgaatagcaataaatattttcccag 
               
               
                   
                   
                 cagggttagcataaaggaatcatctgtagcgaaactagga 
               
               
                   
                   
                 tcagtatgccgtaggatttacagaatattttcacatgctt 
               
               
                   
                   
                 attttcatcatcggcagatatttgatgaatatgaaaatga 
               
               
                   
                   
                 aacatttttgtgtcatcggtttactaagtttgtgatgaaa 
               
               
                   
                   
                 tacaatttgatgtccaaggataacctgattgtaccaattt 
               
               
                   
                   
                 tagaagaggaagtacagaattcagtttctggggaaagtga 
               
               
                   
                   
                 agcatgaagggaatcataggaaaaatgtactgatcatata 
               
               
                   
                   
                 attaacattatgtactgtatatatcattttagacacatca 
               
               
                   
                   
                 atcatgtatccatattatagcttctttgtttagtataggt 
               
               
                   
                   
                 ttttgtatgctgggtttgccttttaaaatgggaaatactt 
               
               
                   
                   
                 tttaagttattcataagctgtatattcaccagtgtggcac 
               
               
                   
                   
                 tcatggtttt 
               
               
                   
               
               
                 161 
                 212204_at 
                 gcttaactcttttgacatctgctattgtgacacatcccat 
               
               
                   
                   
                 tgctggcaatgtggtgcacactccgaaacttttaactact 
               
               
                   
                   
                 gttttgtaagcctccaagggtggcattgcagggtccttag 
               
               
                   
                   
                 gcaatgttttgtttgcctttatgcagagaggtgctccaag 
               
               
                   
                   
                 tgctgtgattgagcaccgtgctagaggaactgtaatgctt 
               
               
                   
                   
                 cagaagttgtagcttatacaaaggaaacaggtcctgctgg 
               
               
                   
                   
                 cttaatttaaacagttattgcatgaagtagcgtggaggcc 
               
               
                   
                   
                 ctggactgctgctcgttctttaggatggactgttctggta 
               
               
                   
                   
                 tctggtattggtttagagactgttaataagggacatcaca 
               
               
                   
                   
                 aggtgatgggattcatttgaagcactctatttctgtttta 
               
               
                   
                   
                 atg 
               
               
                   
               
               
                 162 
                 219452_at 
                 atcacttcgaccacatcaaggctgtcattggatccaagtt 
               
               
                   
                   
                 catcgggattggtggagattatgatggggccggcaaattc 
               
               
                   
                   
                 cctcaggggctggaagacgtgtccacatacccggtcctga 
               
               
                   
                   
                 tagaggagttgctgagtcgtggctggagtgaggaagagct 
               
               
                   
                   
                 tcagggtgtccttcgtggaaacctgctgcgggtcttcaga 
               
               
                   
                   
                 caagtggaaaaggtacaggaagaaaacaaatggcaaagcc 
               
               
                   
                   
                 ccttggaggacaagttcccggatgagcagctgagcagttc 
               
               
                   
                   
                 ctgccactccgacctctcacgtctgcgtcagagacagagt 
               
               
                   
                   
                 ctgacttcaggccaggaactcactgagattcccatacact 
               
               
                   
                   
                 ggacagccaagttaccagccaagtggtcagtctcagagtc 
               
               
                   
                   
                 ctccccccacatggccccagtccttgcagttgtggccacc 
               
               
                   
                   
                 ttcccagtccttattctgtggctctgatgacccagttagt 
               
               
                   
                   
                 cctgccagatgtcactgta 
               
               
                   
               
               
                 163 
                 219889_at 
                 tactcaagcgggtggctctgggatcctgggggcctgggtt 
               
               
                   
                   
                 gggggctagggagacgccatgtgatggacactccagggac 
               
               
                   
                   
                 acacagcctagcacagcagcttataatgggctctccgggg 
               
               
                   
                   
                 ccatttgcaataacagctgcaattccctggatagacgagt 
               
               
                   
                   
                 tgatttcctccctctgcccctcccccagccataccagctg 
               
               
                   
                   
                 gcctttgtaagtgcaggaaaccgagtagaaaatgtgaccc 
               
               
                   
                   
                 tccaaatggagaagctgccagctttgccattgtgaaccat 
               
               
                   
                   
                 ggtgaagtgcttggaacatactgttcactcactctaaagg 
               
               
                   
                   
                 cgctgagactgtgctgttgttctcgtttttatagtcaatg 
               
               
                   
                   
                 gcttgttcatcatccagatgtggctactgacatatctaca 
               
               
                   
                   
                 cttcgcaccggagtgtctggaatt 
               
               
                   
               
               
                 164 
                 201303_at 
                 caacttcactgtatcctcaatgcatggagacatgccccag 
               
               
                   
                   
                 aaagagcgggagtccatcatgaaggagttccggtcgggcg 
               
               
                   
                   
                 ccagccgagtgcttatttctacagatgtctgggccagggg 
               
               
                   
                   
                 gttggatgtccctcaggtgtccctcatcattaactatgat 
               
               
                   
                   
                 ctccctaataacagagaattgtacatacacagaattggga 
               
               
                   
                   
                 gatcaggtcgatacggccggaagggtgtggccattaactt 
               
               
                   
                   
                 tgtaaagaatgacgacatccgcatcctcagagatatcgag 
               
               
                   
                   
                 cagtactattccactcagattgatgagatgccgatgaacg 
               
               
                   
                   
                 ttgctgatcttatctgaagcagcagatcagtgggatgagg 
               
               
                   
                   
                 gagactgttcacctgctgtgtactcctgtttggaagtatt 
               
               
                   
                   
                 tagatccagattctacttaatggggtttatatggactttc 
               
               
                   
                   
                 ttctcataaatggcctgccgtctc 
               
               
                   
               
               
                 165 
                 202510_s_at 
                 gtcgtctttctattttcaggtcagctgattagccacctta 
               
               
                   
                   
                 gttccatctgcaactttagttcccactggctgtgtaacct 
               
               
                   
                   
                 aacatagtcacaggctctggggactgtcacgtggacatct 
               
               
                   
                   
                 ttgggaggccgttattctgcccaccgcaccctccgttcat 
               
               
                   
                   
                 cccctgccctgccgggcacctcgctctaccccaggaaaat 
               
               
                   
                   
                 gtgagctcgttttcctgctcggcatgtgctccccctaagg 
               
               
                   
                   
                 ctctgctcctccctgggcctgaaagttccttctcagcctg 
               
               
                   
                   
                 agagggggcccttcgatctcaggcatgactcagcccggct 
               
               
                   
                   
                 gatgcctctgcagtgctgagtcaggatttggggccggctc 
               
               
                   
                   
                 tcttgggtctgtccccttttcccaggtactgccttacaaa 
               
               
                   
                   
                 gctgtggccaggaagtggccggtataaaggatgcccaagg 
               
               
                   
                   
                 tctttgtacgtgtg 
               
               
                   
               
               
                 166 
                 221923_s_at 
                 tagtccatactgagtgtcatcaacaatccagactgaagtc 
               
               
                   
                   
                 ttctattttaatctcaatccccttttctgatttgccaccc 
               
               
                   
                   
                 atgcctcttcaggctggaaacaatctcttggttccctaaa 
               
               
                   
                   
                 gcactttcttctgactgctgtgattcagtgaaccttgccc 
               
               
                   
                   
                 tttgctttctattacttgtgcatttgcctcacctgacaat 
               
               
                   
                   
                 gttttaaatcgcctttgtatctccttagctgctcaataa 
               
               
                   
               
               
                 167 
                 201887_at 
                 ctgggaagcaaaacccatgcctccccctagccatttttac 
               
               
                   
                   
                 tgttatcctatttagatggccatgaagaggatgctgtgaa 
               
               
                   
                   
                 attcccaacaaacattgatgctgacagtcatgcagtctgg 
               
               
                   
                   
                 gagtggggaagtgatcttttgttcccatcctcttctttta 
               
               
                   
                   
                 gcagtaaaatagctgagggaaaagggagggaaaaggaagt 
               
               
                   
                   
                 tatgggaatacctgtggtggttgtgatccctaggtcttgg 
               
               
                   
                   
                 gagctcttggaggtgtctgtatcagtggatttcccatccc 
               
               
                   
                   
                 ctgtgggaaattagtaggctcatttactgttttaggtcta 
               
               
                   
                   
                 gcctatgtggattttttcctaacatacctaagcaaaccca 
               
               
                   
                   
                 gtgtcaggatggtaattcttattctttcgttcagttaagt 
               
               
                   
                   
                 ttttcccttcatctgggcactgaagggatatgtgaaacaa 
               
               
                   
                   
                 tgttaacatttttggtagtcttcaaccagggattgtt 
               
               
                   
               
               
                 168 
                 211582_x_at 
                 agcccacctgctggatgaggaacttgaggcaagtcaccag 
               
               
                   
                   
                 cccctgatcatttcgcctaaaagagcaaggactagagttc 
               
               
                   
                   
                 ctgacctccaggccagtccctgatccctgacctaatgtta 
               
               
                   
                   
                 tcgcggaatgatgatatatgtatctacgggggcctggggc 
               
               
                   
                   
                 tgggcgggctcctgcttctggcagtggtccttctgtccgc 
               
               
                   
                   
                 ctgcctgtgttggctgcatcgaagagcaccttctgtcctg 
               
               
                   
                   
                 gtcccaggcccagggctcctcagagcaggaactccactat 
               
               
                   
                   
                 gcatctctgcagaggctgccagtgcccagcagtgagggac 
               
               
                   
                   
                 ctgacctcaggggcagagacaagagaggcaccaaggagga 
               
               
                   
                   
                 tccaagagctgactatgcctgcattgctgagaacaaaccc 
               
               
                   
                   
                 acctgagcaccccagacaccttcctcaacccaggcgggtg 
               
               
                   
                   
                 gaca 
               
               
                   
               
               
                 169 
                 219030_at 
                 agttaacacatcagctggacctatttcccgaatgcagggt 
               
               
                   
                   
                 aacccttctgttatttaaagatgtaaaaaatgcgggagac 
               
               
                   
                   
                 ttgagaagaaaggccatggaaggcaccatcgatggatcac 
               
               
                   
                   
                 tgataaatcctacagtgattgttgatccatttcagatact 
               
               
                   
                   
                 tgtggcagcaaacaaagcagttcacctctacaaactggga 
               
               
                   
                   
                 aaaatgaagacaagaactctatctactgaaattattttca 
               
               
                   
                   
                 acctttccccaaataacaatatttcagaggctttgaaaaa 
               
               
                   
                   
                 atttggtatctcagcaaatgacacttcaattctaattgtt 
               
               
                   
                   
                 tacattgaagagggagaaaaacaaataaatcaagaatacc 
               
               
                   
                   
                 taatatctcaagtagaaggtcatcaggtttctctgaaaaa 
               
               
                   
                   
                 tcttcctgaaataatgaatattacagaagtcaaaaagata 
               
               
                   
                   
                 tataaactctcttcacaagaagaaagtatcgggacattat 
               
               
                   
                   
                 tggatgctat 
               
               
                   
               
               
                 170 
                 212706_at 
                 agatatttaggtgacttacagcaaccaatngcaacanaac 
               
               
                   
                   
                 aaaatgttaagaaatgatctttntatgaggcaatnggaaa 
               
               
                   
                   
                 tttgaacactgatcaactataggatgattggaattattaa 
               
               
                   
                   
                 tttttaaaggtgtgataagatactgcacttggctgggcac 
               
               
                   
                   
                 agtggcacatgcctgtaatcccagctacttggcaggctga 
               
               
                   
                   
                 ggtgggagaatcgcttaagctcaggagttcgagaccagcc 
               
               
                   
                   
                 tgggcaacgtggcgaaatccccgtctttacaaaaacaaac 
               
               
                   
                   
                 aaacaaacaaaaaagatattgcagttgtgttgtaagcgtc 
               
               
                   
                   
                 cttatctttcagagctacatagtggaatgtttatggaata 
               
               
                   
                   
                 tttaggataaatgatataggcatttgggatttgctgcaaa 
               
               
                   
                   
                 atgacccagagg 
               
               
                   
               
               
                 171 
                 202902_s_at 
                 caaaatatcgtgctgccacatgttcaaagtacactgaact 
               
               
                   
                   
                 tccttatgggagagaagatgtcctgaaagaagctgtggcc 
               
               
                   
                   
                 aataaaggcccagtgtctgttggtgtagatgcgcgtcatc 
               
               
                   
                   
                 cttctttcttcctctacagaagtggtgtctactatgaacc 
               
               
                   
                   
                 atcctgtactcagaatgtgaatcatggtgtacttgtggtt 
               
               
                   
                   
                 ggctatggtgatcttaatgggaaagaatactggcttgtga 
               
               
                   
                   
                 aaaacagctggggccacaactttggtgaagaaggatatat 
               
               
                   
                   
                 tcggatggcaagaaataaaggaaatcattgtgggattgct 
               
               
                   
                   
                 agctttccctcttacccagaaatctagaggatctctcctt 
               
               
                   
                   
                 tttataacaaatcaagaaatatgaagcactttctcttaac 
               
               
                   
                   
                 ttaatttttcctgctgtat 
               
               
                   
               
               
                 172 
                 200663_at 
                 tgtcttatgatcacgtttgccatctttctgtctcttatca 
               
               
                   
                   
                 tgttggtggaggtggccgcagccattgctggctatgtgtt 
               
               
                   
                   
                 tagagataaggtgatgtcagagtttaataacaacttccgg 
               
               
                   
                   
                 cagcagatggagaattacccgaaaaacaaccacactgctt 
               
               
                   
                   
                 cgatcctggacaggatgcaggcagattttaagtgctgtgg 
               
               
                   
                   
                 ggctgctaactacacagattgggagaaaatcccttccatg 
               
               
                   
                   
                 tcgaagaaccgagtccccgactcctgctgcattaatgtta 
               
               
                   
                   
                 ctgtgggctgtgggattaatttcaacgagaaggcgatcca 
               
               
                   
                   
                 taaggagggctgtgtggagaagattgggggctggctgagg 
               
               
                   
                   
                 aaaaatgtgctggtggtagctgcagcagcccttggaattg 
               
               
                   
                   
                 cttttgtcgaggttttgggaattgtctttgcctgctgcct 
               
               
                   
                   
                 cgtgaagagtat 
               
               
                   
               
               
                 173 
                 202138_x_at 
                 cagaataaaaaacagccccgccaagactatcagctgggat 
               
               
                   
                   
                 tcactttaatttggaagaatgtgccgaagacgcagatgaa 
               
               
                   
                   
                 attcagcatccagacgatgtgccccatcgaaggcgaaggg 
               
               
                   
                   
                 aacattgcacgtttcttgttctctctgtttggccagaagc 
               
               
                   
                   
                 ataatgctgtcaacgcaacccttatagatagctgggtaga 
               
               
                   
                   
                 tattgcgatttttcagttaaaagagggaagcagtaaagaa 
               
               
                   
                   
                 aaagccgctgttttccgctccatgaactctgctcttggga 
               
               
                   
                   
                 agagcccttggctcgctgggaatgaactcaccgtagcaga 
               
               
                   
                   
                 cgtggtgctgtggtctgtactccagcagatcggaggctgc 
               
               
                   
                   
                 agtgtgacagtgccagccaatgtgcagaggtggatgaggt 
               
               
                   
                   
                 cttgtgaaaacctggctccttttaacacggccctcaagct 
               
               
                   
                   
                 ccttaagtgaattgccgtaactgattttaaagggtttaga 
               
               
                   
                   
                 ttttaagaatggtgctctttcatgcctattatcagta 
               
               
                   
               
               
                 174 
                 200851_s_at 
                 gttgaaggcctcgcttagttgtactggattctcagggagc 
               
               
                   
                   
                 cctctgtggccttttgctttgcgtgctgtttcccttgtac 
               
               
                   
                   
                 cagagggcggcaccgtggaaattctgttttccctgtagca 
               
               
                   
                   
                 tattgtgttggattgcattactggcagagaaaggacaagg 
               
               
                   
                   
                 tgccattcaagtcctagggtgggcttccagctgccttaat 
               
               
                   
                   
                 agaagtactcaagtcttttgggtagtgagctggaaagcct 
               
               
                   
                   
                 acaggaaaagaggggtacctgttttcatttgaaaactttg 
               
               
                   
                   
                 attcatggaacctttaaaactaatctcagaaaaatttttg 
               
               
                   
                   
                 gtgcccatgcagctgtagttgttcactgctttcctggatg 
               
               
                   
                   
                 gatgggactcttatgtcataacttctgttactcctttggc 
               
               
                   
                   
                 ccatagctaaggtcatccttccccacaggggtggctttgg 
               
               
                   
                   
                 gattggatgatacagcttttgcttctgtgtagtatacctg 
               
               
                   
                   
                 tacatacttgtttcaggcagcctttc 
               
               
                   
               
               
                 175 
                 201109_s_at 
                 tcatgatgctgactggcgttagctgattaacccatgtaaa 
               
               
                   
                   
                 taggcacttaaatagaagcaggaaagggagacaaagactg 
               
               
                   
                   
                 gcttctggacttcctccctgatccccacccttactcatca 
               
               
                   
                   
                 cctngcagtggccagaattagggaatcagaatcaaaccag 
               
               
                   
                   
                 tgtaaggcagtgctggctgccattgcctggtcacattgaa 
               
               
                   
                   
                 attggtggcttcattctagatgtagcttgtgcagatgtag 
               
               
                   
                   
                 caggaaaataggaaaacctaccatctcagtgagcaccagc 
               
               
                   
                   
                 tgcctcccaaaggaggggcagccgtgcttatatttttatg 
               
               
                   
                   
                 gttacaatggcacaaaattattatcaacctaactaaaaca 
               
               
                   
                   
                 ttccttttctcttttttcctgaattatcatggagttttct 
               
               
                   
                   
                 aattctctcttttggaatgtangattttttttaaatgctt 
               
               
                   
                   
                 tacgatgtaaaatatttattttttacttattctggaagat 
               
               
                   
                   
                 ctggctgaaggattattcatggaacaggaagaagcgtaaa 
               
               
                   
                   
                 gactatccatgtcatctttgttgagagtcttcgtgact 
               
               
                   
               
               
                 176 
                 202531_at 
                 acaggagtcagtgtctggctttttcctctgagcccagctg 
               
               
                   
                   
                 cctggagagggtctcgctgtcactggctggctcctagggg 
               
               
                   
                   
                 aacagaccagtgaccccagaaaagcataacaccaatccca 
               
               
                   
                   
                 gggctggctctgcactaagcgaaaattgcactaaatgaat 
               
               
                   
                   
                 ctcgttccaaagaactaccccttttcagctgagccctggg 
               
               
                   
                   
                 gactgttccaaagccagtgaatgtgaaggaaactcccctc 
               
               
                   
                   
                 cttcggggcaatgctccctcagcctcagaggagctctacc 
               
               
                   
                   
                 ctgctccctgctttggctgaggggcttgggaaaaaaactt 
               
               
                   
                   
                 ggcactttttcgtgtggatcttgccacatttctgatcaga 
               
               
                   
                   
                 ggtgtacactaacatttcccccgagctcttggcctttgca 
               
               
                   
                   
                 tttatttatacagtgccttgctcggggcccaccaccccct 
               
               
                   
                   
                 caagccccagcagccctcaacaggcccagggagggaagtg 
               
               
                   
                   
                 tgagcgccttggtatgacttaa 
               
               
                   
               
               
                 177 
                 216274_s_at 
                 ggaatgattgtctcatcggcactaatgatctggaaggggt 
               
               
                   
                   
                 taatggtaataactggaagtgaaagtccgattgtagtggt 
               
               
                   
                   
                 gctcagtggcagcatggaacctgcatttcatagaggagat 
               
               
                   
                   
                 cttctctttctaacaaatcgagttgaagatcccatacgag 
               
               
                   
                   
                 tgggagaaattgttgttttcaggatagaaggaagagagat 
               
               
                   
                   
                 tcctatagttcaccgagtcttgaagattcatgaaaagcaa 
               
               
                   
                   
                 aatgggcatatcaagtttttgaccaaaggagataataatg 
               
               
                   
                   
                 cggttgatgaccgaggcctctataaacaaggacaacattg 
               
               
                   
                   
                 gctagagaaaaaagatgttgtggggagagccaggggattt 
               
               
                   
                   
                 gttccttatattggaatngtgacgatcctcatgaatgact 
               
               
                   
                   
                 atcctaaatttangtatgcagttctctttttgctgggttt 
               
               
                   
                   
                 attcgtgctggtncatcgtgagtaagaagcctgccttgct 
               
               
                   
                   
                 gttcctgggaagatgccatagttttcgttactg 
               
               
                   
               
               
                 178 
                 200041_s_at 
                 agaggctttctcggtatcagcagtttaaagattttcaacg 
               
               
                   
                   
                 acgaattcttgtggctaccaacctatttggccgaggcatg 
               
               
                   
                   
                 gacatcgagcgggtgaacattgcttttaattatgacatgc 
               
               
                   
                   
                 ctgaggattctgacacctacctgcatcgggtggccagagc 
               
               
                   
                   
                 aggccggtttggcaccaagggcttggctatcacatttgtg 
               
               
                   
                   
                 tccgatgagaatgatgccaagatcctcaatgatgtgcagg 
               
               
                   
                   
                 atcgctttgaggtcaatattagtgagctgcctgatgagat 
               
               
                   
                   
                 agacatctcctcctacattgaacagacacggtagaagact 
               
               
                   
                   
                 cgcccattttggaatgtg 
               
               
                   
               
               
                 179 
                 200052_s_at 
                 ggacatggtctgctatacagctcagactctcgtccgaatc 
               
               
                   
                   
                 ctctcacatggtggctttaggaagatccttggccaggagg 
               
               
                   
                   
                 gtgatgccagctatcttgcttctgaaatatctacctggga 
               
               
                   
                   
                 tggagtgatagtaacaccttcagaaaaggcttatgagaag 
               
               
                   
                   
                 ccaccagagaagaaggaaggagaggaagaagaggagaata 
               
               
                   
                   
                 cagaaagaaccacctcaaggagaggaagaagaaagcatgg 
               
               
                   
                   
                 aaactcaggagtgacattcccttcactccttttcctaccc 
               
               
                   
                   
                 aagggaaagactggagcctaagctgcctgctactggcttt 
               
               
                   
                   
                 acatggtgacagacattccgtggataggaagatagcagga 
               
               
                   
                   
                 gaaagtaactccatagagtgtcattccactggttgatatt 
               
               
                   
                   
                 ggcttagctgccagtctcccatttgtgacctatgccatcc 
               
               
                   
                   
                 atctataatggaggataccaacatttcttcctaatattct 
               
               
                   
                   
                 ataatctccaactcctga 
               
               
                   
               
               
                 180 
                 200064_at 
                 aatagacttgtgtcttcaccttgctgcattgtgaccagca 
               
               
                   
                   
                 cctacggctggacagccaatatggagcggatcatgaaagc 
               
               
                   
                   
                 ccaggcacttcgggacaactccaccatgggctatatgatg 
               
               
                   
                   
                 gccaaaaagcacctggagatcaaccctgaccaccccattg 
               
               
                   
                   
                 tggagacgctgcggcagaaggctgaggccgacaagaatga 
               
               
                   
                   
                 taaggcagttaaggacctggtggtgctgctgtttgaaacc 
               
               
                   
                   
                 gccctgctatcttctggcttttcccttgaggatccccaga 
               
               
                   
                   
                 cccactccaaccgcatctatcgcatgatcaagctaggtct 
               
               
                   
                   
                 aggtattgatgaagatgaagtggcagcagaggaacccaat 
               
               
                   
                   
                 gctgcagttcctgatgagatcccccctctcgagggcgatg 
               
               
                   
                   
                 aggatgcgtctcgcatggaagaagtcgattaggttaggag 
               
               
                   
                   
                 ttcatagttggaaaacttgtgcccttgtatagtgtccc 
               
               
                   
               
               
                 181 
                 200079_s_at 
                 agctgccagaaacgaacctctttgaaactgaagaaactcg 
               
               
                   
                   
                 caaaattcttgatgatatctgtgtggcaaaagctgttgaa 
               
               
                   
                   
                 tgccctccacctcggaccacagccaggctccttgacaagc 
               
               
                   
                   
                 ttgttggggagttcctggaagtgacttgcatcaatcctac 
               
               
                   
                   
                 attcatctgtgatcacccacagataatgagccctttggct 
               
               
                   
                   
                 aaatggcaccgctctaaagagggtctgactgagcgctttg 
               
               
                   
                   
                 agctgtttgtcatgaagaaagagatatgcaatgcgtatac 
               
               
                   
                   
                 tgagctgaatgatcccatgcggcagcggcagctttttgaa 
               
               
                   
                   
                 gaacaggccaaggccaaggctgcaggtgatgatgaggcca 
               
               
                   
                   
                 tgttcatagatgaaaacttctgtactgccctggaatatgg 
               
               
                   
                   
                 gctgccccccacagctggctggggcatgggcattgatcga 
               
               
                   
                   
                 gtcgccatgtttctcacggactccaacaacatcaaggaag 
               
               
                   
                   
                 tacttctgtttcctgccatgaaacccga 
               
               
                   
               
               
                 182 
                 200629_at 
                 tccagtttactgaactccagaccatgcatgtagtccactc 
               
               
                   
                   
                 cagaaatcatgctcgcttcccttggcacaccagtgttctc 
               
               
                   
                   
                 ctgccaaatgaccctagaccctctgtcctgcagagtcagg 
               
               
                   
                   
                 gtggcttttcccctgactgtgtccgatgccaaggagtcct 
               
               
                   
                   
                 ggcctccgcagatgcttcattttgacccttggctgcagtg 
               
               
                   
                   
                 gaagtcagcacagagcagtgccctggctgtgtcctggacg 
               
               
                   
                   
                 ggtggacttagctagggagaaagtcgaggcagcagccctc 
               
               
                   
                   
                 gaggccctcacagatgtctaggcaggcctcatttcatcac 
               
               
                   
                   
                 gcagcatgtgcaggcctggaagagcaaagccaaatctcag 
               
               
                   
                   
                 ggaagtccttggttgatgtatctgggtctcctc 
               
               
                   
               
               
                 183 
                 200634_at 
                 gaaaacgttcgtcaacatcacgccagctgaggtgggtgtc 
               
               
                   
                   
                 ctggttggcaaagaccggtcaagtttttacgtgaatgggc 
               
               
                   
                   
                 tgacacttgggggccagaaatgttcggtgatccgggactc 
               
               
                   
                   
                 actgctgcaggatggggaatttagcatggatcttcgtacc 
               
               
                   
                   
                 aagagcaccggtggggcccccaccttcaatgtcactgtca 
               
               
                   
                   
                 ccaagactgacaagacgctagtcctgctgatgggcaaaga 
               
               
                   
                   
                 aggtgtccacggtggtttgatcaacaagaaatgttatgaa 
               
               
                   
                   
                 atggcctcccaccttcggcgttcccagtactgacctcgtc 
               
               
                   
                   
                 tgtcccttccccttcaccgctccccacagctttgcacccc 
               
               
                   
                   
                 tttcctccccatacacacacaaaccattttattttttggg 
               
               
                   
                   
                 ccattaccccataccccttattgctgccaaaaccacatg 
               
               
                   
               
               
                 184 
                 200802_at 
                 taattgcacggattaccaggctcgccggcttcgaatccga 
               
               
                   
                   
                 tatgggcaaaccaagaagatgatggacaaggtggagtttg 
               
               
                   
                   
                 tccatatgctcaatgctaccatgtgcgccactacccgtac 
               
               
                   
                   
                 catctgcgccatcctggagaactaccagacagagaagggc 
               
               
                   
                   
                 atcactgtgcctgagaaattgaaggagttcatgccgccag 
               
               
                   
                   
                 gactgcaagaactgatcccctttgtgaagcctgcgcccat 
               
               
                   
                   
                 tgagcaggagccatcaaagaagcagaagaagcaacatgag 
               
               
                   
                   
                 ggcagcaaaaagaaagcagcagcaagagacgtcaccctag 
               
               
                   
                   
                 aaaacaggctgcagaacatggaggtcaccgatgcttgaac 
               
               
                   
                   
                 attcctgcctccctatttgccaggctttcatttctgtctg 
               
               
                   
                   
                 ctgagatctcagagcctgcccaacagcagggaagccaagc 
               
               
                   
                   
                 acccattcatccccctgcccccatctgactgcgtagctga 
               
               
                   
                   
                 gaggggaacagtgccatgtaccacacagatgttcctgtct 
               
               
                   
                   
                 cctcgcatgggcatagggacc 
               
               
                   
               
               
                 185 
                 200860_s_at 
                 acttcagttgcaccatgctgtacctttttgcagaggccaa 
               
               
                   
                   
                 tacggaagccatccaagaacagatcacaagagttctcttg 
               
               
                   
                   
                 gaacggttgattgtaaataggccacatccttggggtcttc 
               
               
                   
                   
                 ttattaccttcattgagctgattaaaaacccagcgtttaa 
               
               
                   
                   
                 gttctggaaccatgaatttgtacactgtgccccagaaatc 
               
               
                   
                   
                 gaaaagttattccagtcggtcgcacagtgctgcatgggac 
               
               
                   
                   
                 agaagcaggcccagcaagtaatggaagggacaggtgccag 
               
               
                   
                   
                 ttagacgaaactgcatctctgttgtacgtgtcagtctaga 
               
               
                   
                   
                 ggtctcactgcaccgagttcataaactgactgaagaatcc 
               
               
                   
                   
                 tttcagctcttcctgactttcccagccctttggtttgtgg 
               
               
                   
                   
                 gtatctgccccaactactgttgggatcagcctcctgtctt 
               
               
                   
                   
                 atgtgggcacgttcca 
               
               
                   
               
               
                 186 
                 200983_x_at 
                 aggagttgagacctacttcacagtagttctgtggacaatc 
               
               
                   
                   
                 acaatgggaatccaaggagggtctgtcctgttcgggctgc 
               
               
                   
                   
                 tgctcgtcctggctgtcttctgccattcaggtcatagcct 
               
               
                   
                   
                 gcagtgctacaactgtcctaacccaactgctgactgcaaa 
               
               
                   
                   
                 acagccgtcaattgttcatctgattttgatgcgtgtctca 
               
               
                   
                   
                 ttaccaaagctgggttacaagtgtataacaagtgttggaa 
               
               
                   
                   
                 gtttgagcattgcaatttcaacgacgtcacaacccgcttg 
               
               
                   
                   
                 agggaaaatgagctaacgtactactgctgcaagaaggacc 
               
               
                   
                   
                 tgtgtaactttaacgaacagcttgaaaatggtgggacatc 
               
               
                   
                   
                 cttatcagagaaaacagttcttctgctggtgactccattt 
               
               
                   
                   
                 ctggcagcagcctggagccttcatccctaagtcaacacca 
               
               
                   
                   
                 ggagagcttctcccaaactccccgttcctgcgtagtccgc 
               
               
                   
                   
                 tttctcttgctgccacattctaaagg 
               
               
                   
               
               
                 187 
                 200991_s_at 
                 tgccacccgggagtctatggtcaaactctcaagtaagctg 
               
               
                   
                   
                 agtgccgtgagcttgcggggaattggcagtcccagcacag 
               
               
                   
                   
                 atgccagtgccagtgatgtccacggcaatttcgccttcga 
               
               
                   
                   
                 gggcattggagatgaggatctgtaatctccactgcttgga 
               
               
                   
                   
                 tgtctgccctctaccccagaggaatttacagaaacttgcc 
               
               
                   
                   
                 ctgtgcctgtgtcccccatgctaggggcggaggggtcttt 
               
               
                   
                   
                 tccttcttctttcctacctaccccttttctcttggccagg 
               
               
                   
                   
                 ggcctcgtatcctacctttccttgtcccctgggctggctg 
               
               
                   
                   
                 cacagaggattgccccttctcttttcagagctggccctcg 
               
               
                   
                   
                 atgccaaattagcat 
               
               
                   
               
               
                 188 
                 201112_s_at 
                 agatctgtgcggttggcataaccaacttactaacagaatg 
               
               
                   
                   
                 tcccccaatgatggacactgagtataccaaactgtggact 
               
               
                   
                   
                 ccattattacagtctttgattggtctttttgagttacccg 
               
               
                   
                   
                 aagatgataccattcctgatgaggaacattttattgacat 
               
               
                   
                   
                 agaagatacaccaggatatcagactgccttctcacagttg 
               
               
                   
                   
                 gcatttgctgggaaaaaagagcatgatcctgtaggtcaaa 
               
               
                   
                   
                 tggtgaataaccccaaaattcacctggcacagtcacttca 
               
               
                   
                   
                 catgttgtctaccgcctgtccaggaagggttc 
               
               
                   
               
               
                 189 
                 201214_s_at 
                 agagctgcaagagttctggatgaacgacaatctccttgag 
               
               
                   
                   
                 agctggagcgacctcgacgagctgaagggagccaggagcc 
               
               
                   
                   
                 tggagacagtgtacctggagcggaaccccttgcagaagga 
               
               
                   
                   
                 cccccagtaccggcggaaggtcatgctcgccctcccctcc 
               
               
                   
                   
                 gtgcggcagatcgatgccacgttcgtcaggttctgagtcc 
               
               
                   
                   
                 ttcttggctcctcatgtggtccctctcctcggaagaactg 
               
               
                   
                   
                 cccagccacgggtttttaacccacctgttgctcctgaggt 
               
               
                   
                   
                 cgtcactatatcaacagtcacaaacccaatggcaataaag 
               
               
                   
                   
                 gcactgacgatagctggc 
               
               
                   
               
               
                 190 
                 201241_at 
                 aggatgggtctggcaatttccctggtggcaacagaaaaag 
               
               
                   
                   
                 aaaaggtttggtaccatgtatgtagcagccgtggaaaagg 
               
               
                   
                   
                 gtgttataacacaagactcaaggaagatggaggctgtacc 
               
               
                   
                   
                 atatggtacaacgagatgcagttactatctgagatagaag 
               
               
                   
                   
                 aacacctgaactgtaccatttctcaggttgagccggatat 
               
               
                   
                   
                 aaaggtaccagtggatgaatttgatgggaaagttacctac 
               
               
                   
                   
                 ggtcagaaaagggctgctggtggtggaagctataaaggcc 
               
               
                   
                   
                 atgtggatattttggcacctactgttcaagagttggctgc 
               
               
                   
                   
                 ccttgaaaaggaggcgcagacatctttcctgcatcttggc 
               
               
                   
                   
                 taccttcctaaccagctgttcagaa 
               
               
                   
               
               
                 191 
                 201263_at 
                 gatctggatccaggctgtacattgaataaaaagattcgaa 
               
               
                   
                   
                 atgcacagttagcacagtataacttcattttagttgttgg 
               
               
                   
                   
                 tgaaaaagagaaaatcactggcactgttaatatccgcaca 
               
               
                   
                   
                 agagacaataaggtccacggggaacgcaccatttctgaaa 
               
               
                   
                   
                 ctatcgagcggctacagcagctcaaagagttccgcagcaa 
               
               
                   
                   
                 acaggcagaagaagaattttaatgaaaaaattacccagat 
               
               
                   
                   
                 tggctccatggaaaaggaggaacagcgtttccgtaaaatt 
               
               
                   
                   
                 gactttgtactcgaaaacgtcaatttatattgaacttgga 
               
               
                   
                   
                 ggaggagtttggcaaagtctgaaataggtcaacctgcagg 
               
               
                   
                   
                 cgtaactattt 
               
               
                   
               
               
                 192 
                 201386_s_at 
                 ggagatcatctgacactgctgaacgtctaccatgctttta 
               
               
                   
                   
                 aacaaaatcatgaatcggttcagtggtgttatgacaactt 
               
               
                   
                   
                 cattaactacaggtccctgatgtccgcagacaatgtacgc 
               
               
                   
                   
                 cagcagctatctcgaattatggacagatttaatttgcctc 
               
               
                   
                   
                 gtcgaagtactgactttacaagcagggactattatattaa 
               
               
                   
                   
                 tataagaaaagctttggttactgggtattttatgcaggtg 
               
               
                   
                   
                 gcacatttagaacgaacagggcattacttaactgtgaaag 
               
               
                   
                   
                 ataaccaggtggttcagttgcatccctctactgttcttga 
               
               
                   
                   
                 ccacaaacctgaatgggtgctttataatgagtttgttcta 
               
               
                   
                   
                 acaacaaagaattacatccggacatgtacagatatcaagc 
               
               
                   
                   
                 cagaatggttggtgaaaattgcccctcaatattatgacat 
               
               
                   
                   
                 gagcaatttcccacagtgtgaagcaaagagacagttggac 
               
               
                   
                   
                 cgcatcattgcc 
               
               
                   
               
               
                 193 
                 201417_at 
                 gtaaaccacatcttttttgcactttttttataagcaaaaa 
               
               
                   
                   
                 cgtgccgtttaaaccactggatctatctaaatgccgattt 
               
               
                   
                   
                 gagttcgcgacactatgtactgcgtttttcattcttgtat 
               
               
                   
                   
                 ttgactatttaatcctttctacttgtcgctaaatataatt 
               
               
                   
                   
                 gttttagtcttatggcatgatgatagcatatgtgttcagg 
               
               
                   
                   
                 tttatagctgttgtgtttaaaaattgaaaaaagtggaaaa 
               
               
                   
                   
                 catctttgtacatttaagtctgtattataataagcaaaaa 
               
               
                   
                   
                 gattgtgtgtatgtatgtttaatataacatgacaggcact 
               
               
                   
                   
                 aggacgtctgcctttttaaggcagttccgttaagggtttt 
               
               
                   
                   
                 tgtttttaaacttttttttgccatccatcctgtgcaatat 
               
               
                   
                   
                 gccgtgta 
               
               
                   
               
               
                 194 
                 201576_s_at 
                 aatggctttaaccttggccgctattggccagcccggggcc 
               
               
                   
                   
                 ctcagttgaccttgtttgtgccccagcacatcctgatgac 
               
               
                   
                   
                 ctcggccccaaacaccatcaccgtgctggaactggagtgg 
               
               
                   
                   
                 gcaccctgcagcagtgatgatccagaactatgtgctgtga 
               
               
                   
                   
                 cgttcgtggacaggccagttattggctcatctgtgaccta 
               
               
                   
                   
                 cgatcatccctccaaacctgttgaaaaaagactcatgccc 
               
               
                   
                   
                 ccacccccgcaaaaaaacaaagattcatggctggaccatg 
               
               
                   
                   
                 tatgatgatgaaagcctgtgtctttgagggattctaccct 
               
               
                   
                   
                 gaacatacctcacagatcctccctgtcatgccacatttca 
               
               
                   
                   
                 ctgattggaatgtggaaatggaaaaggaatttaggatgtg 
               
               
                   
                   
                 cattttcacctgaggtttccct 
               
               
                   
               
               
                 195 
                 201872_s_at 
                 gagatccaaacaactataggccacgaataaacaaacttaa 
               
               
                   
                   
                 ttcaattaaggatgtagaacaaaagaagagtggaaactac 
               
               
                   
                   
                 tttttcttggatgattagactgactctgagaatattgata 
               
               
                   
                   
                 agccatttattaaaaggagtatttactagaattttttgtc 
               
               
                   
                   
                 atataaaacttgaatcaggattttatgccccacatactct 
               
               
                   
                   
                 ggaacttgaagtataatatacttaatataacataaaaagc 
               
               
                   
                   
                 cagttgggttctaaattgtagttgaaacacagaaaatgcc 
               
               
                   
                   
                 acttttctgttcctgaagaggctcttttgtgcataatatt 
               
               
                   
                   
                 ctaaaatgaagacatttcaagctatacaaattacttccaa 
               
               
                   
                   
                 gttttcatgatgtatgggaagattttcagtaggtgtatta 
               
               
                   
                   
                 tattcacggtaccaaatgctgaccagtgttgctccatttt 
               
               
                   
                   
                 ttaaatcttgaaaagggtttctgtacttacctggtttgcc 
               
               
                   
                   
                 aagtatgccagtgtaatgaaactgcccttattttaaaagc 
               
               
                   
                   
                 cagtcaaagattccactgattgacatttgat 
               
               
                   
               
               
                 196 
                 201892_s_at 
                 tgtcagagtatgcacggcgctttggtgttccggtcattgc 
               
               
                   
                   
                 tgatggaggaatccaaaatgtgggtcatattgcgaaagcc 
               
               
                   
                   
                 ttggcccttggggcctccacagtcatgatgggctctctcc 
               
               
                   
                   
                 tggctgccaccactgaggcccctggtgaatacttcttttc 
               
               
                   
                   
                 cgatgggatccggctaaagaaatatcgcggtatgggttct 
               
               
                   
                   
                 ctcgatgccatggacaagcacctcagcagccagaacagat 
               
               
                   
                   
                 atttcagtgaagctgacaaaatcaaagtggcccagggagt 
               
               
                   
                   
                 gtctggtgctgtgcaggacaaagggtcaatccacaaattt 
               
               
                   
                   
                 gtcccttacctgattgctggcatccaacactcatgccagg 
               
               
                   
                   
                 acattggtgccaagagcttgacccaagtccgagccatgat 
               
               
                   
                   
                 gtactctggggagcttaagtttgagaagagaacgtcctca 
               
               
                   
                   
                 gcccaggtggaaggtggcgtccatagcctccattcgtatg 
               
               
                   
                   
                 agaagcggcttttctgaaaagggatccagcacacctcct 
               
               
                   
               
               
                 197 
                 202174_s_at 
                 caacctttaaatagtgctgcccataaggagtcacctccta 
               
               
                   
                   
                 ctgttgattcaactcaacagcctaaccctttgccgttacg 
               
               
                   
                   
                 tttacctgaaatggaacccttagtgcctagagtcaaagaa 
               
               
                   
                   
                 gttaaatctgctcaggaaactcctgaaagctctctggctg 
               
               
                   
                   
                 gaagtcctgatactgaatctccagtgttagtgaatgacta 
               
               
                   
                   
                 tgaagcagaatctggtaatataagtcaaaagtctgatgaa 
               
               
                   
                   
                 gaagattttgtaaaagttgaagatttaccactgaaactga 
               
               
                   
                   
                 caa 
               
               
                   
               
               
                 198 
                 202176_at 
                 ggtgatcacgaaactcgctggcatggaggaggaagacttg 
               
               
                   
                   
                 gcgttttcgacaaaagaagagcaacagcagctcttacaga 
               
               
                   
                   
                 aagtcctggcagccactgacctggatgccgaggaggaggt 
               
               
                   
                   
                 ggtggctggggaatttggctccagatccagccaggcatct 
               
               
                   
                   
                 cggcgctttggcaccatgagttctatgtctggggccgacg 
               
               
                   
                   
                 acactgtgtacatggagtaccactcatcgcggagcaaggc 
               
               
                   
                   
                 gcccagcaaacatgtacacccgctcttcaagcgctttagg 
               
               
                   
                   
                 aaatgatgcttaggcagggtacttcgttcaagaccggcgc 
               
               
                   
                   
                 ttggcacccttgttggaaagggattttcagcataacattt 
               
               
                   
                   
                 tccttccacctctttgaccttccctccagcgttggccaaa 
               
               
                   
                   
                 ttgtgctgaggaagatgcatcaagggcttggctgtgcctt 
               
               
                   
                   
                 cataggtcatctagggttttataaaggaggaggagacaat 
               
               
                   
                   
                 attttttcaaactttttggggagtggggtcatttctgtat 
               
               
                   
                   
                 at 
               
               
                   
               
               
                 199 
                 202220_at 
                 tgatccaaagctggcaccttcaggcacattggtctcatag 
               
               
                   
                   
                 ccattactgtttttattgcccttctaagatcctgtcttca 
               
               
                   
                   
                 gctgggtcagagaaaacttcttgactaaaactggtcagaa 
               
               
                   
                   
                 ctcatcacagaaatgaaatacagtggtctctctctcccag 
               
               
                   
                   
                 aactggttgcagctaaaacagagagatctgactgctggct 
               
               
                   
                   
                 ataggattttggacttaatgactgaaattgcaaattgtcc 
               
               
                   
                   
                 tttttcttggcattacagattttgccaaaataactttttg 
               
               
                   
                   
                 tatcaaatattgatgtgtgaaagtgaaggagctagtctgc 
               
               
                   
                   
                 tgaaccaggaatagtttgagatattgaactgtcatttttg 
               
               
                   
                   
                 cacatttgaatactttgcaggctggctttgtataaactta 
               
               
                   
                   
                 tcctctggtttcctatatgttgt 
               
               
                   
               
               
                 200 
                 202225_at 
                 gatactgtaaagtccacacacacattaaatcttgttttcc 
               
               
                   
                   
                 tgaaagtatggcatcaaaaatacttgtagaaaaaccttgt 
               
               
                   
                   
                 cacaactgatttgaatgttcctattntnnnnnnctttgac 
               
               
                   
                   
                 tttgatattggcttgtaatgtctcttttcatcatatgtaa 
               
               
                   
                   
                 tatcagtggaacaggcagcgctactcaagtcctaaggatt 
               
               
                   
                   
                 cctcagtgatcagtgatccagggccgttcatgaaccactg 
               
               
                   
                   
                 ggctggatttgactgttgagtgtggcagttaatgcccctc 
               
               
                   
                   
                 aagaaatcaaaggatgtcttataagtgtcttccaaaaaaa 
               
               
                   
                   
                 agcaaatgctgaaatcctattggc 
               
               
                   
               
               
                 201 
                 202464_s_at 
                 tattctgtcctgagaccacgggcaaagctcttccattttg 
               
               
                   
                   
                 agagagaagaaaaactgtttggaaccacaccaatgatatt 
               
               
                   
                   
                 tttctttgtaatacttgaaatttatttttttattattttg 
               
               
                   
                   
                 atagcagatgtgctatttatttatttaatatatgtataag 
               
               
                   
                   
                 gagtcctaaacaatagaaagctgtagaagctgtagagata 
               
               
                   
                   
                 ggcttcagttgttaattggtttggagcctcctatgtgtga 
               
               
                   
                   
                 cttatgactctctgtgttctgtgtatttgtctgaattaat 
               
               
                   
                   
                 gacctgggatataaagctatgctagctttcaaacaggaga 
               
               
                   
                   
                 tgccttcagaaagctttgtatattttgcagttgccagacc 
               
               
                   
                   
                 aataaaatacc 
               
               
                   
               
               
                 202 
                 202545_at 
                 atcgcccctgagatcctacagggcctgaagtacacattct 
               
               
                   
                   
                 ctgtggactggtggtctttcggggtccttctgtacgagat 
               
               
                   
                   
                 gctcattggccagtcccccttccatggtgatgatgaggat 
               
               
                   
                   
                 gaactcttcgagtccatccgtgtggacacgccacattatc 
               
               
                   
                   
                 cccgctggatcaccaaggagtccaaggacatcctggagaa 
               
               
                   
                   
                 gctctttgaaagggaaccaaccaagaggctgggaatgacg 
               
               
                   
                   
                 ggaaacatcaaaatccaccccttcttcaagaccataaact 
               
               
                   
                   
                 ggactctgctggaaaagcggaggttggagccacccttcag 
               
               
                   
                   
                 gcccaaagtgaagtcacccagagactacagtaactttgac 
               
               
                   
                   
                 caggagttcctgaacgagaaggcgcgcctctcctacagcg 
               
               
                   
                   
                 acaagaacctcatcgactccatggaccagtctgcattcgc 
               
               
                   
                   
                 tggct 
               
               
                   
               
               
                 203 
                 202838_at 
                 agaaagaggcgctgctcactgttttcctgcttcagttttt 
               
               
                   
                   
                 ctcttatagtaccatcactataatcaacgaacttctcttc 
               
               
                   
                   
                 tccacccagagatggcttttccaacacattttaattaaag 
               
               
                   
                   
                 gaactgagtacattaccctgatgtctaaatggaccaaaga 
               
               
                   
                   
                 tctgagatccattgtgattatatctgtatcaggtcagcag 
               
               
                   
                   
                 aagaaggaactgagcagttgaactctgagttcatcaattc 
               
               
                   
                   
                 taatatttggaaattatctacaatggaatcttccctctgt 
               
               
                   
                   
                 tctctgataacctacttgcttactcaatgcctttaagcca 
               
               
                   
                   
                 agtcaccctgttgcctatgggaggaggtggaaggatttgg 
               
               
                   
                   
                 caagctcaaccacatgctatttagttagcatcagttgtca 
               
               
                   
                   
                 ccaacagtctttctgcaaagggcaggagagctttggggga 
               
               
                   
                   
                 aaggaaaaggcttaccaggctgctatggtcaactcttcag 
               
               
                   
                   
                 aa 
               
               
                   
               
               
                 204 
                 202896_s_at 
                 ccaccacccaactggggctagagtggggaagatttcccct 
               
               
                   
                   
                 ttagatcaaactgccccttccatggaaaagctggaaaaaa 
               
               
                   
                   
                 actctggaacccatatccaggcttggtgaggttgctgcca 
               
               
                   
                   
                 acagtcctggcctcccccatccctaggcaaagagccatga 
               
               
                   
                   
                 gtcctggaggaggagaggacccctcccaaaggactggaag 
               
               
                   
                   
                 caaaaccctctgcttccttgggtccctccaagactccctg 
               
               
                   
                   
                 gggcccaactgtgttgctccacccggacccatctctccct 
               
               
                   
                   
                 tctagacctgagcttgcccctccagctagcactaagcaac 
               
               
                   
                   
                 atctcgctgtaagcgcctgtaaattactgtgaaatgtgaa 
               
               
                   
                   
                 acgtgcaatcttgaaactgaggtgtt 
               
               
                   
               
               
                 205 
                 202950_at 
                 taacatgttagttgtcatttggcatgagtgtgcattccag 
               
               
                   
                   
                 taattcttaattgatatttgattaattccatacctttgat 
               
               
                   
                   
                 taaaacatgctagttcaaaataagactgctcagtttccaa 
               
               
                   
                   
                 gggttttcaagcctacttacctttataaaggttctctagt 
               
               
                   
                   
                 ctctgattagccatgactgtattggactttgaacattttc 
               
               
                   
                   
                 tgaactaaaaacctctattctaaactaatctcatttggat 
               
               
                   
                   
                 gtgtaagtcttttgtaaaggcaagaataaataatatccag 
               
               
                   
                   
                 gacaatttattagttttctcagtattttcccaaatattag 
               
               
                   
                   
                 aatatttacttcattattggttggctgccaatgaccccat 
               
               
                   
                   
                 atgttctgtgagaatagtagctttatctttgatataatac 
               
               
                   
                   
                 atagtctccaaataggtaatacttcgcaattgattagatt 
               
               
                   
                   
                 ttcagagtagatttagagttatctgtttttctggtgaggg 
               
               
                   
                   
                 tcaaat 
               
               
                   
               
               
                 206 
                 203037_s_at 
                 Agtagtgcctgtggtttagcccaccaatcttgatgactaa 
               
               
                   
                   
                 aagtagctgatgcattgtgcatatgatgcttgagatggtt 
               
               
                   
                   
                 tttgcaaaagcagaaatcgctgcaaggtaatcacaataga 
               
               
                   
                   
                 taaaagtggtattttaaacctttgaaataaatggatgtaa 
               
               
                   
                   
                 ctgtaccttggtacagcttttcacttgtttagtttttaaa 
               
               
                   
                   
                 cgttagtataatctgaataaataaaatgttgccaaattca 
               
               
                   
                   
                 atgtagaaagaatgtgacaacacaccttgggtagttctgc 
               
               
                   
                   
                 ttgtgtttttgcatattgtaaaagcagtgtcacagctaaa 
               
               
                   
                   
                 aagaaagaaatcgtttctaacagtaaattattgtgcttta 
               
               
                   
                   
                 gttgctagtttgtactgagagttgacctctccctgtgcag 
               
               
                   
                   
                 ttttttgttctaaacttgtataaataacaattgtgtaatg 
               
               
                   
                   
                 tgtctccctcctacattgtaacaatt 
               
               
                   
               
               
                 207 
                 203155_at 
                 gtcttcgtggatacccatgatcttcgcttcccctgggtgg 
               
               
                   
                   
                 ccttctttgccagcaaaagaatccgggctgggacagaact 
               
               
                   
                   
                 tacttgggactacaactacgaggtgggcagtgtggaaggc 
               
               
                   
                   
                 aaggagctactctgttgctgtggggccattgaatgcagag 
               
               
                   
                   
                 gacgtcttctttagaggacagccttcttcccaacccttct 
               
               
                   
                   
                 tgaactgtcgtttcctcaggaactgggtcttcctgattgt 
               
               
                   
                   
                 tgaaccctgacccgaagtctctgggctagctactcccccc 
               
               
                   
                   
                 agctcctagttgatagaaatgggggttctggaccagatga 
               
               
                   
                   
                 tcccttccaatgtggtgctagcaggcaggatcccttctcc 
               
               
                   
                   
                 acctccaaaggccctaaagggtggggagagatcaccactc 
               
               
                   
                   
                 taacctcggcctgacatccctcccatcccatatttgtcca 
               
               
                   
                   
                 agtgttcctgcttctaacagactttgttcttagaatggag 
               
               
                   
                   
                 cctgtgtatctactatc 
               
               
                   
               
               
                 208 
                 203371_s_at 
                 Ctttcctgccgtgagaaactcgaggtgaccaacctccgtt 
               
               
                   
                   
                 tccggttggctccggttgcagagttgagtgtcctgagagg 
               
               
                   
                   
                 tcagattgctgtcagacatggcccatgaacatggacatga 
               
               
                   
                   
                 gcatggacatcataaaatggaacttccagattatagacaa 
               
               
                   
                   
                 tggaagatagaagggacaccattagaaactatccagaaga 
               
               
                   
                   
                 agctggctgcaaaagggctaagggatccatggggccgcaa 
               
               
                   
                   
                 tgaagcttggagatacatgggtggctttgcaaagagtgtt 
               
               
                   
                   
                 tccttttctgatgtattctttaaaggattcaaatggggat 
               
               
                   
                   
                 ttgctgcatttgtggtagctgtaggagctgaatattacct 
               
               
                   
                   
                 ggagtccctgaataaagataagaagcatcactgaagataa 
               
               
                   
                   
                 tacctggaagcatcatagtggtttcttaactctccaaaat 
               
               
                   
                   
                 aagatttcttctctgtagcctacttgtctggtttatcc 
               
               
                   
               
               
                 209 
                 203821_at 
                 gagccactctatgagttggacttcagtcttgcctaggcga 
               
               
                   
                   
                 ttttgtctaccatttgtgttttgaaagcccaaggtgctga 
               
               
                   
                   
                 tgtcaaagtgtaacagatatcagtgtctccccgtgtcctc 
               
               
                   
                   
                 tccctgccaagtctcagaagaggttgggcttccatgcctg 
               
               
                   
                   
                 tagctttcctggtccctcacccccatggccccaggccaca 
               
               
                   
                   
                 gcgtgggaactcactttcccttgtgtcaagacatttctct 
               
               
                   
                   
                 aactcctgccattcttctggtgctactccatgcaggggtc 
               
               
                   
                   
                 agtgcagcagaggacagtctggagaaggtattagcaaagc 
               
               
                   
                   
                 aaaaggctgagaaggaacagggaacattggagctgactgt 
               
               
                   
                   
                 tcttggtaactgattacctgccaattgctaccgagaaggt 
               
               
                   
                   
                 tggaggtggggaaggctttgtataatcccacccacctcac 
               
               
                   
                   
                 caaaacgatgaaggtatgctgtcatggtcctttctggaag 
               
               
                   
                   
                 tttctggtgccatttctgaactgttacaac 
               
               
                   
               
               
                 210 
                 203966_s_at 
                 gatgcaacagatatatagccctttcaagtcatgttgtgtt 
               
               
                   
                   
                 tggacttggggttggaacagggagagcagcagccatgtca 
               
               
                   
                   
                 gctacacgctcaaatgtgcagatgattatggaaaataacc 
               
               
                   
                   
                 tcaaaatcttacaaagctgaacatccaaggagttattgaa 
               
               
                   
                   
                 aactatcttaaatgttcttggtaggggagttggcattgtt 
               
               
                   
                   
                 gataaagccagtcccttcatttaactgtctttcaggatgt 
               
               
                   
                   
                 tccttcgttgtttccatgagtattgcaggtaataatacag 
               
               
                   
                   
                 tgtgttccataagaatctcaatcttggggctaaatgcctt 
               
               
                   
                   
                 gtttctttgcacctcttttcaagtccttacatttaattac 
               
               
                   
                   
                 taattgataagcagcagcttcctacatatagtaggaaact 
               
               
                   
                   
                 gccacatttttgctatcat 
               
               
                   
               
               
                 211 
                 204192_at 
                 tacccgcaggactggttccaagtcctcatcctgagaggta 
               
               
                   
                   
                 acgggtcggaggcgcaccgcgtgccctgctcctgctacaa 
               
               
                   
                   
                 cttgtcggcgaccaacgactccacaatcctagataaggtg 
               
               
                   
                   
                 atcttgccccagctcagcaggcttggacacctggcgcggt 
               
               
                   
                   
                 ccagacacagtgcagacatctgcgctgtccctgcagagag 
               
               
                   
                   
                 ccacatctaccgcgagggctgcgcgcagggcctccagaag 
               
               
                   
                   
                 tggctgcacaacaaccttatttccatagtgggcatttgcc 
               
               
                   
                   
                 tgggcgtcggcctactcgagctcgggttcatgacgctctc 
               
               
                   
                   
                 gatattcctgtgcagaaacctggaccacgtctacaa 
               
               
                   
               
               
                 212 
                 204419_x_at 
                 acactcgcttctggaacgtctgaggttatcaataagctcc 
               
               
                   
                   
                 tagtccagacgccatgggtcatttcacagaggaggacaag 
               
               
                   
                   
                 gctactatcacaagcctgtggggcaaggtgaatgtggaag 
               
               
                   
                   
                 atgctggaggagaaaccctgggaaggctcctggttgtcta 
               
               
                   
                   
                 cccatggacccagaggttctttgacagctttggcaacctg 
               
               
                   
                   
                 tcctctgcctctgccatcatgggcaaccccaaagtcaagg 
               
               
                   
                   
                 cacatggcaagaaggtgctgacttccttgggagatgccat 
               
               
                   
                   
                 aaagcacctggatgatctcaagggcacctttgcccagctg 
               
               
                   
                   
                 agtgaactgcactgtgacaagctgcatgtggatcctgaga 
               
               
                   
                   
                 acttcaagctcctgggaaatgtgctggtgaccgttttggc 
               
               
                   
                   
                 aatccatttcggcaaagaattcacccctgaggtgcaggct 
               
               
                   
                   
                 tcctggcagaagatggtgactggagtggccagtgccctgt 
               
               
                   
                   
                 cctccagataccactgagctcactgcc 
               
               
                   
               
               
                 213 
                 204566_at 
                 gccacttgtcttgaaaactgtgcaactttttaaagtaaat 
               
               
                   
                   
                 tattaagcagactggaaaagtgatgtattttcatagtgac 
               
               
                   
                   
                 ctgtgtttcacttaatgtttcttagagccaagtgtctttt 
               
               
                   
                   
                 aaacattattttttatttctgatttcataattcagaacta 
               
               
                   
                   
                 aatttttcatagaagtgttgagccatgctacagttagtct 
               
               
                   
                   
                 tgtcccaattaaaatactatgcagtatctcttacatcagt 
               
               
                   
                   
                 agcatttttctaaaaccttagtcatcagatatgcttacta 
               
               
                   
                   
                 aatcttcagcatagaaggaagtgtgtttgcctaaaacaat 
               
               
                   
                   
                 ctaaaacaattcccttctttttcatcccagaccaatggca 
               
               
                   
                   
                 ttattaggtcttaaagtagttactcccttctcgtgtttgc 
               
               
                   
                   
                 ttaaaatatgtgaagttttccttgctatttcaataacaga 
               
               
                   
                   
                 tggtgctgctaattcccaacatt 
               
               
                   
               
               
                 214 
                 204689_at 
                 cttttctgtaatctgtttatctcccacttaatggaaaggc 
               
               
                   
                   
                 aaaggggtaccccaaatccagaggtgcctacatttcaggc 
               
               
                   
                   
                 agccttggagtattttaaaaggaaaacattctttactttt 
               
               
                   
                   
                 atatgacattcttatactgctgtctcaaatcctttttcat 
               
               
                   
                   
                 ttcagagctcttgtctcagagatgtgtgttctttttgtca 
               
               
                   
                   
                 gagatatggttgatgagaatcttaaatgcttgttttgcac 
               
               
                   
                   
                 tatcacttagtacctgtttgaccaaggtgttaagggatag 
               
               
                   
                   
                 tacctcccatcagcagagaaactg 
               
               
                   
               
               
                 215 
                 205249_at 
                 ggaacgtagcaatatctgctccttttcgagttgtttgaga 
               
               
                   
                   
                 aatgtaggctattttttcagtgtatatccactcagatttt 
               
               
                   
                   
                 gtgtatttttgatgtacccacactgttctctaaattctga 
               
               
                   
                   
                 atctttgggaaaaaatgtaaagcatttatgatctcagagg 
               
               
                   
                   
                 ttaacttatttaagggggatgtacatattctctgaaacta 
               
               
                   
                   
                 ggatgcatgcaattgtgttggaagtgtccttggtcgcctt 
               
               
                   
                   
                 gtgtgatgtagacaaatgttacaaggctgcatgtaaatgg 
               
               
                   
                   
                 gttgccttattatggagaaaaaaatcactccctgagttta 
               
               
                   
                   
                 gtatggctgtatatttatgcctattaatatttggaatttt 
               
               
                   
                   
                 ttttagaaagtatatttttgtatgctttgttttgtgactt 
               
               
                   
                   
                 aaaagtgttacctttgtagtcaaatttcagataagaatgt 
               
               
                   
                   
                 acataatgttaccggagctgatttgtttggtcattagctc 
               
               
                   
                   
                 ttaatagttgtgaaaaaataaatctattctaacgcaaaac 
               
               
                   
                   
                 cact 
               
               
                   
               
               
                 216 
                 205552_s_at 
                 gctcctgacggtctatgcttgggagcgagggagcatgaaa 
               
               
                   
                   
                 acacatttcaacacagcccaggaatttcggacggtcttgg 
               
               
                   
                   
                 aattagtcataaactaccagcaactctgcatctactggac 
               
               
                   
                   
                 aaagtattatgactttaaaaaccccattattgaaaagtac 
               
               
                   
                   
                 ctgagaaggcagctcacgaaacccacgcctgtgatcctgg 
               
               
                   
                   
                 acccggcggaccctacaggaaacttgggtggtggagaccc 
               
               
                   
                   
                 aaagcgttggaggcagctggcacaagaggctgaggcctgg 
               
               
                   
                   
                 ctgaattacccatgctttaagaattgg 
               
               
                   
               
               
                 217 
                 206115_at 
                 ctcgctccttctggtatatgcatgtcactgcatgataatt 
               
               
                   
                   
                 gagttttcctttgttttaataaaactgttctcagacatta 
               
               
                   
                   
                 agctaaactaagagaaaaataactttgttgccaaaaggtt 
               
               
                   
                   
                 gtgctatccagattttttatatgtctgcatgtttaaaaaa 
               
               
                   
                   
                 aaaaaagcaacaaaagaaaatgcactctaacttatgtgaa 
               
               
                   
                   
                 ctgagagaaaaaaatcaggttttaaacaggaaaacctatg 
               
               
                   
                   
                 gggaatgatattttttgaaagacttttgtataaagttgag 
               
               
                   
                   
                 tacttagaaaaaagacaaaccagatgtaatatattttgtg 
               
               
                   
                   
                 gatgtttttatttcttggatttatagtaccttatactaag 
               
               
                   
                   
                 gttaaaaaaatatgcttgatattgtgaaaaggtgaaattc 
               
               
                   
                   
                 ttcaccaacatttcatttgctcctttgtcatattgtaatg 
               
               
                   
                   
                 ccaatataatatagttaatgaaaacagcatttttaaaaac 
               
               
                   
                   
                 cgaaatattgaaatggtgtaatgttgtaccatttgcactg 
               
               
                   
                   
                 tgagc 
               
               
                   
               
               
                 218 
                 206584_at 
                 tgatgattagttactgatcctctttgcatttgtaaagctt 
               
               
                   
                   
                 tggagatattgaatcatgttaccatttctgtttttttcca 
               
               
                   
                   
                 ccctgttttcttccatatttactgaagctcagaagcagta 
               
               
                   
                   
                 ttgggtctgcaactcatccgatgcaagtatttcatacacc 
               
               
                   
                   
                 tactgtgataaaatgcaatacccaatttcaattaatgtta 
               
               
                   
                   
                 acccctgtatagaattgaaaggatccaaaggattattgca 
               
               
                   
                   
                 cattttctacattccaaggagagatttaaagcaattatat 
               
               
                   
                   
                 ttcaatctctatataactgtcaacaccatgaatcttccaa 
               
               
                   
                   
                 agcgcaaagaagttatttgccgaggatctgatgacgatta 
               
               
                   
                   
                 ctctttttgcagagctctgaagggagagactgtgaataca 
               
               
                   
                   
                 acaatatcattctccttcaagggaataaaattttctaagg 
               
               
                   
                   
                 gaaaatacaaatgtgttgttgaagctatttctgggagccc 
               
               
                   
                   
                 agaagaaatgctcttttgcttggagtttg 
               
               
                   
               
               
                 219 
                 206877_at 
                 gaaaagccgttcaccaaatcgaccagcttcagcgagagca 
               
               
                   
                   
                 gcgacacctgaagaggcagctggagaagctgggcattgag 
               
               
                   
                   
                 aggatccggatggacagcatcggctccaccgtctcctcgg 
               
               
                   
                   
                 agcgctccgactccgacagggaagaaatagacgttgacgt 
               
               
                   
                   
                 ggagagcacggactatctcacaggtgatctggactggagc 
               
               
                   
                   
                 agcagcagtgtgagcgactctgacgagcggggcagcatgc 
               
               
                   
                   
                 agagcctcggcagtgatgagggctattccagcaccagcat 
               
               
                   
                   
                 caagagaataaagctgcaggacagtcacaaggcgtgtctt 
               
               
                   
                   
                 ggtctctaagagagtgggcactgcggctgtctccttgaag 
               
               
                   
                   
                 gttctccctgttggttctgattaggtaacgtattggacct 
               
               
                   
                   
                 gcccacaactcccttgcacgtaaacttcagt 
               
               
                   
               
               
                 220 
                 207170_s_at 
                 aaaacagcactcctttggctggagcacttgtgtccgtgca 
               
               
                   
                   
                 tgtacttgggtgtttccctccatcctttctgatatgacca 
               
               
                   
                   
                 aaaatcaagttgttttgttttttgtcaccttcactggcat 
               
               
                   
                   
                 gggctaaccacttctttttcaaaccctctgaacacctttt 
               
               
                   
                   
                 tctgatgggtaacttgcaggaatattctattggaaaagat 
               
               
                   
                   
                 aacaggaagtacaagtgcttcttgaccccttcctcaatgt 
               
               
                   
                   
                 ttctagccttcactctccattgtcttttctgggctgtatt 
               
               
                   
                   
                 acagccctctgtggatcttcaactctgctgcctccactgt 
               
               
                   
                   
                 gatgcagcagtccaactgtaactgacagtggctgccttct 
               
               
                   
                   
                 ctgggccatggatcaca 
               
               
                   
               
               
                 221 
                 208631_s_at 
                 Ccagaactgctgacacagatggtgtccaagggcttcctag 
               
               
                   
                   
                 gtcgtaaatctgggaagggcttttacatctatcaggaggg 
               
               
                   
                   
                 tgtgaagaggaaggatttgaattctgacatggatagtatt 
               
               
                   
                   
                 ttagcgagtctgaagctgcctcctaagtctgaagtctcat 
               
               
                   
                   
                 cagacgaagacatccagttccgcctggtgacaagatttgt 
               
               
                   
                   
                 gaatgaggcagtcatgtgcctgcaagaggggatcttggcc 
               
               
                   
                   
                 acacctgcagagggagacatcggagccgtctttgggcttg 
               
               
                   
                   
                 gcttcccgccttgtctgggagggcctttccgctttgtgga 
               
               
                   
                   
                 tctgtatggcgcccagaagatagtggaccggctcaagaaa 
               
               
                   
                   
                 tatgaagctgcctatggaaaacagttcaccccatgccagc 
               
               
                   
                   
                 tgctagctgaccatgctaacagccctaacaagaagttcta 
               
               
                   
                   
                 ccagtgagcaggcctcatgcctcgctcagtcagtgcacta 
               
               
                   
                   
                 accccagctgccggcagtgctgattctccaacagagtg 
               
               
                   
               
               
                 222 
                 208691_at 
                 gagttctgtcatgattcactattctagaacttacatgacc 
               
               
                   
                   
                 tttactgtgttagctctttgaatgttcttgaaattttaga 
               
               
                   
                   
                 ctttctttgtaaacaaataatatgtccttatcattgtata 
               
               
                   
                   
                 aaagctgttatgtgcaacagtgtggagattccttgtctga 
               
               
                   
                   
                 tttaataa 
               
               
                   
               
               
                 223 
                 208868_s_at 
                 acatctagaaacattacaccacacacaccgtcatcacatt 
               
               
                   
                   
                 ttcacatgctcaattgatattttttgctgcttcctcggcc 
               
               
                   
                   
                 cagggagaaagcatgtcaggacagagctgttggattggct 
               
               
                   
                   
                 ttgatagaggaatggggatgatgtaagtttacagtattcc 
               
               
                   
                   
                 tggggtttaattgttgtgcagtttcatagatgggtcagga 
               
               
                   
                   
                 ggtggacaagttggggccagagatgatggcagtccagcag 
               
               
                   
                   
                 caactccctgtgctcccttctctttgggcagagattctat 
               
               
                   
                   
                 ttttgacatttgcacaagacaggtagggaaaggggacttg 
               
               
                   
                   
                 tggtagtggaccatacctggggaccaaaagagacccactg 
               
               
                   
                   
                 taattgatgcattgtggcccctgatcttccctgtctcaca 
               
               
                   
                   
                 cttcttttctcccatcccggttgcaatctcactcagacat 
               
               
                   
                   
                 cacagtaccaccccaggggtggcagtagacaacaacccag 
               
               
                   
                   
                 aaatttagacagggatctcttacctttggaaaataggggt 
               
               
                   
                   
                 taggcatgaaggtggttgtgattaagaagatggtt 
               
               
                   
               
               
                 224 
                 208869_s_at 
                 Gactaaaaccactcttagcatctcctctagtattttccat 
               
               
                   
                   
                 gtatcaggacagaggtgtcttatgtagggagggggcaagt 
               
               
                   
                   
                 atgaagtaaggtaattatatactactctcattcaggattc 
               
               
                   
                   
                 ttgctcccatgctgctgtcccttcaggctcacatgcacag 
               
               
                   
                   
                 gaatgctacatgatggccagctgcttccctccttggttat 
               
               
                   
                   
                 catccactgcagctgctagttagaaaggtttggagggatg 
               
               
                   
                   
                 acttttagtaaatcatggggattttattgatttattttca 
               
               
                   
                   
                 cttttgggattttgtggggtgggagtggggagcaggaatt 
               
               
                   
                   
                 gcactcagacatgacatttcaattcatctctgctaatgaa 
               
               
                   
                   
                 aagggttctttctcttgggggaaatgtgtgtgtcagttct 
               
               
                   
                   
                 gtcagctgcaagttcttgtataatgaagtcaatgccatca 
               
               
                   
                   
                 ggccaaggaaataaaa 
               
               
                   
               
               
                 225 
                 208942_s_at 
                 caacatggcggaacgcaggagacacaagaagcggatccag 
               
               
                   
                   
                 gaagttggtgaaccatctaaagaagagaaggctgtggcca 
               
               
                   
                   
                 agtatcttcgattcaactgtccaacaaagtccaccaatat 
               
               
                   
                   
                 gatgggtcaccgggttgattattttattgcttcaaaagca 
               
               
                   
                   
                 gtggactgtcttttggattcaaagtgggcaaaggccaaga 
               
               
                   
                   
                 aaggagaggaagctttatttacaaccagggagtctgtggt 
               
               
                   
                   
                 tgactactgcaacaggcttttaaagaagcagttttttcac 
               
               
                   
                   
                 cgagccctaaaagtaatg 
               
               
                   
               
               
                 226 
                 209092_s_at 
                 aaatccaatcatgagtccaggtagagaacgcctgctgtaa 
               
               
                   
                   
                 tctacactgttgctgggactgcgcattctgtatataactg 
               
               
                   
                   
                 tgttggatgagtgacagatgattgtccagactaggacagc 
               
               
                   
                   
                 ggcatgaacatgactttggttgggattgcggatagttagg 
               
               
                   
                   
                 gttacctctgaatcgtgtagcttttatgagagcagctgtg 
               
               
                   
                   
                 caagtgaatccacattaatgccttgtcgtggtgccattcc 
               
               
                   
                   
                 cagcgcctgacgatacgctcttctattgtcttattctggc 
               
               
                   
                   
                 aggttttgacgttttaaattttttaaagaaattttattcc 
               
               
                   
                   
                 ttggaccaaaaggtttggttaaccacccccctcttacttg 
               
               
                   
                   
                 ctttcacattttgagtgtccagaggaaacagaaaggaatg 
               
               
                   
                   
                 agtgtgtgacgttgctgcacgcctgactctgtgcgagctt 
               
               
                   
                   
                 ctttctgtgtatat 
               
               
                   
               
               
                 227 
                 209193_at 
                 gattgtagtggatctaatttttcagaaattttgcctttaa 
               
               
                   
                   
                 gttattttacctgtttttgtttcttgttttgaaagatgcg 
               
               
                   
                   
                 cattctaacctggaggtcaatgttatgtatttatttattt 
               
               
                   
                   
                 atttatttggttcccttcctattccaagcttccatagctg 
               
               
                   
                   
                 ctgccctagttttctttcctcctttcctcctctgacttgg 
               
               
                   
                   
                 ggaccttttgggggagggctgcgacgcttgctctgtttgt 
               
               
                   
                   
                 ggggtgacgggactcaggcgggacagtgctgcagctccct 
               
               
                   
                   
                 ggcttctgtggggcccctcacctacttacccaggtgggtc 
               
               
                   
                   
                 ccggctctgtgggtgatggggaggggcattgctgactgtg 
               
               
                   
                   
                 tatataggataattatgaaaagcagttctggatggtgtgc 
               
               
                   
                   
                 cttccagatcctctctggggctgtgttttgagcagcaggt 
               
               
                   
                   
                 agcctggctggttttatctgagtga 
               
               
                   
               
               
                 228 
                 209200_at 
                 ggagcaatccaagccacatatcttctacatcaaatttttc 
               
               
                   
                   
                 cattttggttattttcataatctggtattgcattttgcct 
               
               
                   
                   
                 tccctgttcatacctcaaattgattcatacctcagtttaa 
               
               
                   
                   
                 ttcagagaggtcagttaagtgacggattctgttgtggttt 
               
               
                   
                   
                 gaatgcagtaccagtgttctcttcgagcaaagtagacctg 
               
               
                   
                   
                 ggtcactgtaggcataggacttggattgcttcagatggtt 
               
               
                   
                   
                 tgctgtatcatttttcttctttttcttttcctggggactt 
               
               
                   
                   
                 gtttccattaaatgagagtaattaaaatcgcttgtaaatg 
               
               
                   
                   
                 agggcatacaagcatttgcaacaaatattcaaatagaggc 
               
               
                   
                   
                 tcacagcggcataagctggactttgtcgccactagatgac 
               
               
                   
                   
                 aagatgttataactaagttaaaccacatctgtgtatctca 
               
               
                   
                   
                 agggact 
               
               
                   
               
               
                 229 
                 209861_s_at 
                 aagtaaatacttgatggctctgaagaatctgtgtgacttg 
               
               
                   
                   
                 ggcattgtagatccatatccaccattatgtgacattaaag 
               
               
                   
                   
                 gatcatatacagcgcaatttgaacataccatcctgttgcg 
               
               
                   
                   
                 tccaacatgtaaagaagttgtcagcagaggagatgactat 
               
               
                   
                   
                 taaacttagtccaaagccacctcaacacctttattttctg 
               
               
                   
                   
                 agctttgttggaaaacatgataccagaattaatttgccac 
               
               
                   
                   
                 atgttgtctgttttaacagtggacccatgtaatactttta 
               
               
                   
                   
                 tccatgtttaaaaagaaggaatttggacaaaggcaaaccg 
               
               
                   
                   
                 tctaatgtaattaacca 
               
               
                   
               
               
                 230 
                 209967_s_at 
                 ttcctaaaaatgcttcactgtacgtagttaagtcgtagct 
               
               
                   
                   
                 ataacttcaaattttttaaaagggacaaactgtaaaaaat 
               
               
                   
                   
                 gtgtgtattcttaaaatgcaatatttgtaaggcttgttcc 
               
               
                   
                   
                 aatgccacatacttgcagctcccattctatgtgtcatcaa 
               
               
                   
                   
                 tagtgtcctatgcaataaattatttgcaggtcttta 
               
               
                   
               
               
                 231 
                 210027_s_at 
                 tgggatgaagcctttcgcaagttcctgaagggcctggctt 
               
               
                   
                   
                 cccgaaagccccttgtgctgtgtggagacctcaatgtggc 
               
               
                   
                   
                 acatgaagaaattgaccttcgcaaccccaaggggaacaaa 
               
               
                   
                   
                 aagaatgctggcttcacgccacaagagcgccaaggcttcg 
               
               
                   
                   
                 gggaattactgcaggctgtgccactggctgacagctttag 
               
               
                   
                   
                 gcacctctaccccaacacaccctatgcctacaccttttgg 
               
               
                   
                   
                 acttatatgatgaatgctcgatccaagaatgttggttggc 
               
               
                   
                   
                 gccttgattactttttgttgtcccactctctgttacctgc 
               
               
                   
                   
                 attgtgtgacagcaagatccgttccaaggccctcgcgagt 
               
               
                   
                   
                 gatcactgtcctatcaccctatacctagcactgtgacacc 
               
               
                   
                   
                 acccctaaatcactttgagcctgggaaataagccccctca 
               
               
                   
                   
                 actaccattccttctttaaacactcttcagagaaatctgc 
               
               
                   
                   
                 attctatttctcatgtataaaacgaggaatcctccaacca 
               
               
                   
                   
                 ggctcctgtgataga 
               
               
                   
               
               
                 232 
                 210053_at 
                 aacgtagttactgtatggcactcaaaaactatgttaaatg 
               
               
                   
                   
                 atccactaactttttttttcttggcccatgattaatggaa 
               
               
                   
                   
                 tgtatgtaactaggtagggttcctttcttagatctagagg 
               
               
                   
                   
                 aagtacagccacccactgacatctgaatttatatacctgt 
               
               
                   
                   
                 tgagttttgagtgcacccaaacactcgataaaccaggtga 
               
               
                   
                   
                 agaaatttagcttccatgttctacttcagctaaaacagct 
               
               
                   
                   
                 acatacaacctagtacacttgaagtcagacagacatttca 
               
               
                   
                   
                 gttgcttacctccagtactgagccttgctttgggaaacta 
               
               
                   
                   
                 aaagatttagaccaagtcactgccagtttttgcctttg 
               
               
                   
               
               
                 233 
                 210172_at 
                 Ggtaaatatacgttctgcatccaaatgcactttgagattg 
               
               
                   
                   
                 ttacgatttattctgagcaagatctgcattttttgaaagt 
               
               
                   
                   
                 ttgagattgtagttatcttttttgagatgagatactttca 
               
               
                   
                   
                 cgactttggtatcatctgtcagtttttgcccagtgagttc 
               
               
                   
                   
                 tgcatttgcagctccttgttttggtctgttcgtaactgca 
               
               
                   
                   
                 gtgttctccatgagtatcaggaaggtagggtttcacttag 
               
               
                   
                   
                 gagtaagaacagtccccagtccagcagccacccttttcag 
               
               
                   
                   
                 ctgctgttcattgccagttgatgaggtgagtgtcatctgc 
               
               
                   
                   
                 ctctctggacaggccccagtggagaacaccgcaggtactg 
               
               
                   
                   
                 taaaccaagtacttttcacagcgtggccttt 
               
               
                   
               
               
                 234 
                 210766_s_at 
                 Ggttccatcaatggtgagcaccagcctgaatgcagaagcg 
               
               
                   
                   
                 ctccagtatctccaagggtaccttcaggcagccagtgtga 
               
               
                   
                   
                 cactgctttaaactgcatttttctnaatgggctaaaccca 
               
               
                   
                   
                 gatggtttcctaggaaatcacaggcttctgagcacagctg 
               
               
                   
                   
                 catt 
               
               
                   
               
               
                 235 
                 210949_s_at 
                 acaaagtccgcaccatgctggttaggaagatccaggaaga 
               
               
                   
                   
                 gtcactgaggacctacctcttcacctacagcagtgtctat 
               
               
                   
                   
                 gactccatcagcatggagacgctgtcagacatgtttgagc 
               
               
                   
                   
                 tggatctgcccactgtgcactccatcatcagcaaaatgat 
               
               
                   
                   
                 cattaatgaggagctgatggcctccctggaccagccaaca 
               
               
                   
                   
                 cagacagtggtgatgcaccgcactgagcccactgcccagc 
               
               
                   
                   
                 agaacctggctctgcagctggccgagaagctgggcagcct 
               
               
                   
                   
                 ggtggagaacaacgaacgggtgtttgaccacaagcagggc 
               
               
                   
                   
                 acctacgggggctacttccgagaccagaaggacggctacc 
               
               
                   
                   
                 gcaaaaacgagggctacatgc 
               
               
                   
               
               
                 236 
                 211458_s_at 
                 aaatagcattaaactggaattgacagagtgagttgagcat 
               
               
                   
                   
                 ctctgtctaacctgctctttctctctggtgctcctcatct 
               
               
                   
                   
                 cacccctaccttggaatttaataagcttcaggcatttcca 
               
               
                   
                   
                 attgcagactaaaaccacttctaccatctcctctagtatt 
               
               
                   
                   
                 ttccatgtatcaggacagagatgtcttatgtagggaaggg 
               
               
                   
                   
                 gcaggtatgaagtgaggtagattatctatacctctcactc 
               
               
                   
                   
                 attcaggattctcgctcccatgctgctgtcccttcattct 
               
               
                   
                   
                 cacactcacaggaatgctatgtgatggccagctgcttccc 
               
               
                   
                   
                 ttcttggttatccactgcagctgctagttagaaaggtttg 
               
               
                   
                   
                 cagggatgacttttagtaaatcatggggattttattgatt 
               
               
                   
                   
                 tattatcacttataggattttgtggggtgggagtggggag 
               
               
                   
                   
                 caggaattgcactcagacatgacatttcaattcatctctg 
               
               
                   
                   
                 caaatgaaaagggttcttcctcttgggggaaatctgtgtg 
               
               
                   
                   
                 tcagttctgtcagctgcaagttctt 
               
               
                   
               
               
                 237 
                 211546_x_at 
                 gggagttgtggctgctgctgagaaaaccaaacagggtgtg 
               
               
                   
                   
                 gcagaagcagcaggaaagacaaaagagggtgttctctatg 
               
               
                   
                   
                 tagtggctgagaagaccaaagagcaagtgacaaatgttgg 
               
               
                   
                   
                 aggagcagtggtgacgggtgtgacagcagtagcccagaag 
               
               
                   
                   
                 acagtggagggagcagggagcattgcagcagccactggct 
               
               
                   
                   
                 ttgtcaaaaaggaccagttgggcaagaatgaagaaggagc 
               
               
                   
                   
                 cccacaggaaggaattctggaagatatgcctgtggatcct 
               
               
                   
                   
                 gacaatgaggcttatgaaatgccttctgagg 
               
               
                   
               
               
                 238 
                 212199_at 
                 attttgctgttacctttgtgacctgattgttttttggaac 
               
               
                   
                   
                 acgtcaagacgtgggatcagaatcttccaactttagaggt 
               
               
                   
                   
                 gcaatggaagacactacgctacttggttgagcctggtgaa 
               
               
                   
                   
                 gaatgtattaatgagactgctttgcataaaactgggaaga 
               
               
                   
                   
                 aagagaagacagttggagatggaagatggttttgtatata 
               
               
                   
                   
                 ttttggaactttagttcctctgtgagacgaaagaggagag 
               
               
                   
                   
                 ctatgttttgtgtcacattgtctgatatatattgtgtaac 
               
               
                   
                   
                 ctgtcaggtgagttgatttagacaacatagctgacctttt 
               
               
                   
                   
                 atgacaaggcagtttgaatagggactattgtaataccctc 
               
               
                   
                   
                 acacattataggggcancagagaatggcatggaagagaca 
               
               
                   
                   
                 gtctacagagagctttaagaggccggagaaaggaaaagac 
               
               
                   
                   
                 attatcagggcctggaaagtctcttccagttcatcagggt 
               
               
                   
                   
                 ag 
               
               
                   
               
               
                 239 
                 212224_at 
                 acagtgttctctaatgttacagatgagatgcgcattgcca 
               
               
                   
                   
                 aagaggagatttttggaccagtgcagcaaatcatgaagtt 
               
               
                   
                   
                 taaatctttagatgacgtgatcaaaagagcaaacaatact 
               
               
                   
                   
                 ttctatggcttatcagcaggagtgtttaccaaagacattg 
               
               
                   
                   
                 ataaagccataacaatctcctctgctctgcaggcaggaac 
               
               
                   
                   
                 agtgtgggtgaattgctatggcgtggtaagtgcccagtgc 
               
               
                   
                   
                 ccctttggntgggattcaagatgtctggaaatggaagaga 
               
               
                   
                   
                 actgggagagtacggtttccatgaatatacagaggtcaaa 
               
               
                   
                   
                 acagtcacagtgaaaatctctcagaagaactcataaagaa 
               
               
                   
                   
                 aatacaagagtggagagaagctcttcaatagctaagcatc 
               
               
                   
                   
                 tccttacagtcactaatat 
               
               
                   
               
               
                 240 
                 212388_at 
                 gtgacagttatgacaggcttaccttggaagagttgtcatt 
               
               
                   
                   
                 tttactgccaattttttggatgaagatgtttttataaacc 
               
               
                   
                   
                 tttcaaaatggtctgcaaacagagcaggaattgcacaatt 
               
               
                   
                   
                 aactcaataatgctgtgtgttctcaagaagctcccttagt 
               
               
                   
                   
                 gaggccgatcttaagatggccgattctgcccgttgaaggc 
               
               
                   
                   
                 atncctgggaaagaaaacaagcatcccagcgggcatctca 
               
               
                   
                   
                 ccacgacttctcctggagtcctcacacggtcactgacaac 
               
               
                   
                   
                 tacagtcagttttaggaactagagtgccgtatcatcagac 
               
               
                   
                   
                 ttaccctgtcctgccccaccttccctgctaacatcgaggt 
               
               
                   
                   
                 gtgtgcagttaccttctgagcttggaacaagcagactgga 
               
               
                   
                   
                 attttcctctgctacctcttgtgtataaaatcttgttt 
               
               
                   
               
               
                 241 
                 212591_at 
                 ggcccagattgcagatggatttcgtattagagttgatctc 
               
               
                   
                   
                 gcatctgagacctcatctagagacaagagatcggtttttg 
               
               
                   
                   
                 tggggaatctcccttataaagttgaagaatctgccattga 
               
               
                   
                   
                 gaagcactttctggactgtggaagtatcatggccgtgagg 
               
               
                   
                   
                 attgtgagagacaaaatgacaggcatcggcaaagggtttg 
               
               
                   
                   
                 gctatgtgctctttgagaatacagattctgttcatcttgc 
               
               
                   
                   
                 tctgaaattaaataattctgaactcatggggagaaaactc 
               
               
                   
                   
                 agagtcatgcgttctgttaataaagaaaaatttaaacaac 
               
               
                   
                   
                 aaaattcaaatccacgattgaagaatgtcagtaaacctaa 
               
               
                   
                   
                 gcagggacttaattttacttccaaaactgcagaaggacat 
               
               
                   
                   
                 cctaaaagcttatttattggagaaaaagctgttctcctta 
               
               
                   
                   
                 aaacgaagaagaaaggacagaagaaaagtggacgccctaa 
               
               
                   
                   
                 gaaacagagaaaacagaaataacaaccaggaactgctttt 
               
               
                   
                   
                 tcttttcctgctgagtactgctaata 
               
               
                   
               
               
                 242 
                 212696_s_at 
                 ctgaaggagtgtccctcctctatgtgaaaagaaaattgtt 
               
               
                   
                   
                 ttattcttncattctgactttttaancngttnggctcact 
               
               
                   
                   
                 tnccagttagtttgaatgaaaataataattttctacttgg 
               
               
                   
                   
                 nagttgaagagggcagaatccgcagctctcatcattgtga 
               
               
                   
                   
                 tgtgtagcatgtctgccctctgactggacatcattgccat 
               
               
                   
                   
                 taactttcttctgggcatcacggcaatgtcacgatgccca 
               
               
                   
                   
                 gacttggagcaaggcaaccttggagtcagtccactcataa 
               
               
                   
                   
                 aatatggtaacacccattttaaaatttaagttttgtcctt 
               
               
                   
                   
                 aaagacaacttcagtggttaattataaaagttgtgttact 
               
               
                   
                   
                 tcgtcctaaattaaattgatagaaagatttaaaaatgtgt 
               
               
                   
                   
                 tttgtttctactattcagaaactgcgaactagggaaaggt 
               
               
                   
                   
                 tggtatgaaaaaatgtctttccttttttcaatgtacatag 
               
               
                   
                   
                 ttcaactctttctttgttacatttaaactatatccatgga 
               
               
                   
                   
                 tatcagtctgctttggactcctctgctagtgttacagatg 
               
               
                   
               
               
                 243 
                 212709_at 
                 tgcaaattaagactcaccttcactttccaaaatagctgag 
               
               
                   
                   
                 ggttgtnggcttgttgtagctgaccaccaaaagcagtcac 
               
               
                   
                   
                 tgcaaatcttttaattcttccctatcaccttttgtatttt 
               
               
                   
                   
                 aatgcaattattttggtccagaactgacctgtattttctg 
               
               
                   
                   
                 tattgtacacaaaagctaataattttgtgtactttttatt 
               
               
                   
                   
                 tattttggaggttttatatgatcttcaattgagtattaaa 
               
               
                   
                   
                 taatttgcctagattaagcctaaaatgatgaccagctaat 
               
               
                   
                   
                 taaagaagatattttgaatctggttctgagctaaagttga 
               
               
                   
                   
                 gtaaattcttagctaagaaaaaattggaaatccatcatct 
               
               
                   
                   
                 atattagcaacagattctcagagtaaattgttaacttcta 
               
               
                   
                   
                 tgatttatgataatcaagctggacttgatcatacaagtta 
               
               
                   
                   
                 gtctcataatgtattggaccaaaatgtaaacttcattggt 
               
               
                   
                   
                 cagatttagaagcattcatgctcacaagttttggga 
               
               
                   
               
               
                 244 
                 212714_at 
                 aactttaggcttttgggcatatgctagtctgagcttccga 
               
               
                   
                   
                 aaagatacatatatgtttcccttttcattagctgaatgag 
               
               
                   
                   
                 gatattttaagaagttgaaagagaatttattttcaagttg 
               
               
                   
                   
                 tgagtaaatcctcctttgaaattcacctgattattagata 
               
               
                   
                   
                 acttaaagtttatttttaaaagctgacaactttttatgaa 
               
               
                   
                   
                 tcttcgagttgacagttcctaaaagcgtaactcagatatt 
               
               
                   
                   
                 aatgggctgtgtattaaatggttttattttcagttttgca 
               
               
                   
                   
                 gcacagaacactgttgaaatatccatatcaacttgatttt 
               
               
                   
                   
                 tttaacctaattcaggtgtcctttgcatctcttaaatgtt 
               
               
                   
                   
                 gggggtgggggtcagagccagttatccggcttctgttttg 
               
               
                   
                   
                 tcgattgcttagatttgttcctgttgtc 
               
               
                   
               
               
                 245 
                 212893_at 
                 aattgtccttaattaccaacagtgaagcactacaggaggc 
               
               
                   
                   
                 aactgtggcattgcttccttaaccagctcatggtgtgtga 
               
               
                   
                   
                 atgttataaaattgtcactcagatatattttttaaatgta 
               
               
                   
                   
                 atgttatataagatgatcatgtgatgtgtacaaactatgg 
               
               
                   
                   
                 tgaaaagtgccagtggtagtaactgtgtaaagtttctaat 
               
               
                   
                   
                 tcacaacattaattcctttaaaatacacagccttctgcct 
               
               
                   
                   
                 ctgtatttggagttgtcagtacaactcatcaaagaaaact 
               
               
                   
                   
                 gcctaatataaaaatcatatatatggtaataatttccctc 
               
               
                   
                   
                 ttttgtagtctgcacaagatccataaaagattgtattttt 
               
               
                   
                   
                 attactatttaaacaagtgattaaatttagtctgcacagt 
               
               
                   
                   
                 gagcaaaggttcacatgcattcttttatactgctggattt 
               
               
                   
                   
                 tgttgtgcatcatttaaaacattttgtatgtttcttctta 
               
               
                   
                   
                 tctgtatat 
               
               
                   
               
               
                 246 
                 212989_at 
                 gtcagagcctgttcacatattgtgatcaggtaacaatgac 
               
               
                   
                   
                 atgtaccacttaaattattttatcgtcgatttggtagttc 
               
               
                   
                   
                 nattttaactactcaatgaaaacagccatgaatatctttt 
               
               
                   
                   
                 cttaaagagagttttgaaaatgatcacttacctaaaactt 
               
               
                   
                   
                 gaaagctatgaattagttatccatactctcatgacaattt 
               
               
                   
                   
                 tgttggtgaacaacaaaaaagagatctatttctttaaaag 
               
               
                   
                   
                 atatttgtgcagaaactgcatgtaactctaagttttactc 
               
               
                   
                   
                 ctaacatacatatgtttggggaagtattctattctatact 
               
               
                   
                   
                 tgccaatgtggagaacaaaatagttttttaagaatgaaga 
               
               
                   
                   
                 agtatatatatccattctgtattttacgtgcagcagaatt 
               
               
                   
                   
                 atcttccgtaggatttt 
               
               
                   
               
               
                 247 
                 213410_at 
                 gacaaattacggttgagttctgtggcttcttcacttgaag 
               
               
                   
                   
                 tgctaacatcagaatcaaacttaaagcttccactatttat 
               
               
                   
                   
                 gtctttgagaagtatgtagtacctcggtattaacagacct 
               
               
                   
                   
                 gctgtgatgcagttacactttcacgtatttttgaagtatg 
               
               
                   
                   
                 tcaagctacacgggtctaagatatgattattttggataaa 
               
               
                   
                   
                 atgttactttggtcaagagaacttttatccagatgacatt 
               
               
                   
                   
                 acaggttcaagtgggttaaggagacctcctgtacatctac 
               
               
                   
                   
                 agtgtttccttttaaattgtccagaaaaaaggtgtgttct 
               
               
                   
                   
                 tcataaacttcagtgcaggatttttcaaagacgagctgtt 
               
               
                   
                   
                 gtgcaatttgctgtatttaatgcatgttctgaaaggattc 
               
               
                   
                   
                 acttttgactttatatgacagttgatcaagaacaggtact 
               
               
                   
                   
                 accccttt 
               
               
                   
               
               
                 248 
                 213515_x_at 
                 ggatgatctcaagggcacctttgcccagctgagtgaactg 
               
               
                   
                   
                 cactgtgacaagctgcatgtggatcctgagaacttcaagc 
               
               
                   
                   
                 nncctgggaaatgtgctggtgaccgttttggcaatccatt 
               
               
                   
                   
                 tcggcaaagaattcacccctgaggtgcaggcttcctggca 
               
               
                   
                   
                 gaagatggtgactggagtggccagtgccctgtcctccaga 
               
               
                   
                   
                 taccactgagctcactgcccatgatgcagagctt 
               
               
                   
               
               
                 249 
                 213528_at 
                 Aactgcattcaagggagggtccaaagaaattcactttcaa 
               
               
                   
                   
                 gattataacagtatggtgattgatgaagtaaccttaccta 
               
               
                   
                   
                 atgtagtagctaactccactttggaagatgaagaaaatga 
               
               
                   
                   
                 tgtaaatgagccagatgtgaaaagatgcaggaaaccaaaa 
               
               
                   
                   
                 gtaacacaactatataaatgccgatttttttctggtgagt 
               
               
                   
                   
                 ggtctgagttttgtaagcttgtactaagtagtgaaaaact 
               
               
                   
                   
                 ttttgtaaaatatgatctcattctcacctcagaaaccatt 
               
               
                   
                   
                 tacaacccagattattatagtaatttgcaccagactttcc 
               
               
                   
                   
                 ttagactgttaagtaaaaatggacgtgtacttttggccag 
               
               
                   
                   
                 caaagcacattattttggtgtaggtggaggtgttcatctc 
               
               
                   
                   
                 tttcaga 
               
               
                   
               
               
                 250 
                 213604_at 
                 gcaatgtcagtatccattttggcacataaagatttttgat 
               
               
                   
                   
                 gagccctgtttgcatagagccagatgttttcccctccccc 
               
               
                   
                   
                 aagagtatctacatcagggatgtgacttggtgcgaagagt 
               
               
                   
                   
                 caggggaaagaggaaaaacccaatttctaaatgacctcct 
               
               
                   
                   
                 tgcccaacttactaaaatggctgcagagcagacacaggat 
               
               
                   
                   
                 gaatttgaacctgacacaggatgaatttgaacctttggtc 
               
               
                   
                   
                 tcatttatggaaaaacttgtgcaattttttttctgtgcta 
               
               
                   
                   
                 cactacatacaaatcaccaaattacaaattacccttttgt 
               
               
                   
                   
                 gatccttggtgtactgagcagtttctttggggctttttct 
               
               
                   
                   
                 ttctgggaagcgggagggaaaggagcaaggtgtcatcctg 
               
               
                   
                   
                 ctcttc 
               
               
                   
               
               
                 251 
                 213619_at 
                 aatcaaggcctcagaatttcatacaaacaccaagaccaaa 
               
               
                   
                   
                 atcctaagtattggtattgcgtctcaaatttttcccatta 
               
               
                   
                   
                 acttnaaaaaaaaaaaaagcttaaacttacgtgccttaca 
               
               
                   
                   
                 ggttattaaatgaaactagaattaacaaacatgccaaaat 
               
               
                   
                   
                 gtttcacttttaatagtagacacagctcctatattgtttt 
               
               
                   
                   
                 acaaaaaaataaaagcatgtctttcaacatgcatccaaaa 
               
               
                   
                   
                 cagtgttcaatttaacgtggcaaagggcaacatttaacat 
               
               
                   
                   
                 aattcaactgcttttacctaaatacgcttactgcttaagt 
               
               
                   
                   
                 acatcctataactaacttgagaaaagctggaacttaagtt 
               
               
                   
                   
                 taacagttatagtttactcagcttcactgttacatcctag 
               
               
                   
                   
                 atgagtattgtattcaaaaatactgggccttaagtcttca 
               
               
                   
                   
                 taacaatcctgatttccacttagagt 
               
               
                   
               
               
                 252 
                 213655_at 
                 cttcaacgctaacctgcttcagtgggagagtaaagtaggc 
               
               
                   
                   
                 aagaatgagcagccacggattgttgaactgttaccagcac 
               
               
                   
                   
                 catgcttttcagcaacatttcagcggagttggaaacattt 
               
               
                   
                   
                 tttacagcaaaaccattacaacgaagtccctccccaaacc 
               
               
                   
                   
                 acctttaaccatctcaagctaacacccaattacttgcaaa 
               
               
                   
                   
                 cactggtataaaacacagtttaaacaattagaaaaatgaa 
               
               
                   
                   
                 aactgataccacttatgcctctatagtgtgattaacctct 
               
               
                   
                   
                 ctcttagatgcttgcatcacctataagtctaatggctttc 
               
               
                   
                   
                 aaatgtaatttccatttgctaatggtgatcttgccacatc 
               
               
                   
                   
                 tggcacggagacgacacagtaatgctgaaaaagcctctat 
               
               
                   
                   
                 gtagtcctgttagtgtcttaaagaacctaaaagctgggac 
               
               
                   
                   
                 cagtaaaatccacagaaattcactcttgccttta 
               
               
                   
               
               
                 253 
                 213743_at 
                 ttgtgtgagctattcaaactcttcaacccctgaacagggt 
               
               
                   
                   
                 attaagcttccaaaataatgatggggataaatatggaaat 
               
               
                   
                   
                 cctttttaagttgtatttccattaaacaaaaacccttata 
               
               
                   
                   
                 attcatactatcatgaatttgctttatccatctcatttgc 
               
               
                   
                   
                 ataacagttcatctgtctggtcccattaggctctaccaaa 
               
               
                   
                   
                 gaaagactctgatgagtggacattattactgtgactcttg 
               
               
                   
                   
                 taagtagccataaataaaccaaaatagtatcaaatttagg 
               
               
                   
                   
                 tatgaaattccacatgtgcaaa 
               
               
                   
               
               
                 254 
                 213788_s_at 
                 gtttcagtcatttccggactaactgtgacaacgcgtgagc 
               
               
                   
                   
                 agggagcaccgtgcgagtctccgggagggaatcctcctgg 
               
               
                   
                   
                 ggcccagagactcctccacccctggggagggcagagaggc 
               
               
                   
                   
                 tcgggagggcctggccaggccactggaggctggcagggag 
               
               
                   
                   
                 caggcatgtccacccgcaagcctgggaggctaactctggc 
               
               
                   
                   
                 attcctggccggagccgccatgctcattggtgggccagtt 
               
               
                   
                   
                 tgggacatccccgtactcaaagaccatatggcaggctctg 
               
               
                   
                   
                 ggaaaacaaaaccaaaacatcaccttctattaaactctgt 
               
               
                   
                   
                 atattattattttttacaatagaaagttaaaaatcaagac 
               
               
                   
                   
                 ttagatttactatacattttttctctcagattacaaagtt 
               
               
                   
                   
                 tatattatataactggggttccctaaattgatttctttta 
               
               
                   
                   
                 aaacagtcttaaagagaccagaagtgaatacaaaagaact 
               
               
                   
                   
                 aaacaaaataaaaaattagaatatgctgtagctgaaagct 
               
               
                   
                   
                 gtctatacctgtaagcctccaagtttcat 
               
               
                   
               
               
                 255 
                 213872_at 
                 aaactggtcagctagagattcttttttctttctaagctga 
               
               
                   
                   
                 gcacgtagtctgttcagagcttgtttcttccgggagtttg 
               
               
                   
                   
                 ggtcccccattttgaaatncnggtggtactaaagcctttg 
               
               
                   
                   
                 gaaattgtcactaaactatgggcactttttcttaagactc 
               
               
                   
                   
                 aagtacaacagaaacaagtcattttttttcctgctaatat 
               
               
                   
                   
                 gattgattagcgaaaatcacgactataacccaaaaactgc 
               
               
                   
                   
                 accttctgtcaatattagcagactgtcatattacagggtc 
               
               
                   
                   
                 aagaaacaaaagctgctgtccagtcatgtttggacaataa 
               
               
                   
                   
                 cgtttggggtcagacgggaaaaagggaggaaagaaaggaa 
               
               
                   
                   
                 agaaagaggagaaaataactaactttctggaaaacacatt 
               
               
                   
                   
                 tggcttaactgccaaaataaaggctttgcggagaaatgaa 
               
               
                   
                   
                 aagcctataatcaggatttaggtgtgcaataaaacacagc 
               
               
                   
                   
                 tgacaccagaccaatccctaaaatccatccggattttccc 
               
               
                   
                   
                 ccctttttagaaaagggattaaggaacagggagggggaag 
               
               
                   
                   
                 tgtgatccttgctttc 
               
               
                   
               
               
                 256 
                 213979_s_at 
                 aaatggttacagtcacaaacatgattttaaccaaaatatt 
               
               
                   
                   
                 gctagcctaccacatcagcaggacggcactggtgcaggca 
               
               
                   
                   
                 gggacgctgccaccctccacgtccccaggacagacgtcga 
               
               
                   
                   
                 tgggcagcgggcacgctcggcaccgcccaagcttttcctt 
               
               
                   
                   
                 ttggagctgcttcgtgatgccgtcttcatttggaacaagg 
               
               
                   
                   
                 gggggttcatgccaaaattaggaaaaacagcctttgtttt 
               
               
                   
                   
                 gtttttctaaattattctaaaaataagacaagcaggtaga 
               
               
                   
                   
                 aaaaacaatgcactgtgtggcataaaaagaaaaaggggaa 
               
               
                   
                   
                 ggattcattgtcctgagaagtttgccaactgcctcattct 
               
               
                   
                   
                 ggggcacgttccaacataca 
               
               
                   
               
               
                 257 
                 214257_s_at 
                 attataacctgggcctgcctttgttctcatgaagccagga 
               
               
                   
                   
                 gcctctccatatcctatacttgctcttacgctaataacaa 
               
               
                   
                   
                 accaaatgctgcaaaataaaagtaataatgacccaaacta 
               
               
                   
                   
                 atttaagtcttttgtttaaggagtaaatgagagaaacatt 
               
               
                   
                   
                 ttagcttcttaatcaaggagtgctataatttcaaggcatc 
               
               
                   
                   
                 ttaatataattcacttaccctaaagcaattgtgcaataag 
               
               
                   
                   
                 caaattataaaaggaaaacaacaaaggttaactttctaca 
               
               
                   
                   
                 ggggccaatagacaagatctgtggagcacagcaattaacc 
               
               
                   
                   
                 ttcacatactggagtcttgtttaaaaggcgatcaaaaact 
               
               
                   
                   
                 cagattactga 
               
               
                   
               
               
                 258 
                 214414_x_at 
                 tcaacttcaagctcctaagccactgcctgctggtgaccct 
               
               
                   
                   
                 ggccgcccacctccccgccgagttcaacccctgnggtgca 
               
               
                   
                   
                 cgcctccctgganaagttcctggcttctgtgagcaccgtg 
               
               
                   
                   
                 ctgacctccaaataccgttaagctggagcctcggtagccg 
               
               
                   
                   
                 ttcnnnnnncnngctnggcnntccaacgggccctcctccc 
               
               
                   
                   
                 ctccttgcaccggcccttcctggtctttgaataaagtctg 
               
               
                   
                   
                 agtg 
               
               
                   
               
               
                 259 
                 214696_at 
                 gagtatacatcggtgcaggcttcctggatgacagttgggt 
               
               
                   
                   
                 gatatgtgtcatgtggcctaaaagcctccatgtcatttga 
               
               
                   
                   
                 cctacgaattctatctttgggaatttatcctaagaaanta 
               
               
                   
                   
                 cttanggatttanttngtgataagatgttcatcccagcat 
               
               
                   
                   
                 tgcaatggagaaaaatgggaagcaatggtttggttgggaa 
               
               
                   
                   
                 tttattccttttctgctgtaacgaaagtttgcaatagggg 
               
               
                   
                   
                 attgcttaagtaaattattgtatctccatccagatggtgg 
               
               
                   
                   
                 agtaccgcgcagacattaaaagtcatgtaaaagaacatct 
               
               
                   
                   
                 gactgaaagaaaaatgctccttgaatattaaaaggttgta 
               
               
                   
                   
                 aaaatagtgcatgttatgtgatttcaattttgttttttaa 
               
               
                   
                   
                 aatatgggtgtatgcttgtatacgtagagcagataaaaaa 
               
               
                   
                   
                 gacggaaggcatactaaaaaatgttgagtggttatctttg 
               
               
                   
                   
                 tatggtggaacaaagtcactgtaattttcatctttggtt 
               
               
                   
               
               
                 260 
                 214933_at 
                 aatctttcctttccctgatgaagacagctggtggccgagt 
               
               
                   
                   
                 gcggnaangaagccagaaggaaccagaatcccagngccct 
               
               
                   
                   
                 acacccaccaccagacacactcacacccacacacgttctc 
               
               
                   
                   
                 agacacacacaagagtgcttgccggttataccaaacccta 
               
               
                   
                   
                 ctattactgcctgcagaaatcaatttaaaaaaataataat 
               
               
                   
                   
                 aacaataaacaattttaaaaaggacaaaaaaattaatgat 
               
               
                   
                   
                 tgagaaaagaggcatttttttctgacatttggtcctgctt 
               
               
                   
                   
                 gaaacaacaaaagaagaagaaaaacccaccatcaccaccg 
               
               
                   
                   
                 attcctttgcttcttttttccttttttcctaccttgtttg 
               
               
                   
                   
                 aaaaccgtgggcttgggactgtgaattattgcatgacat 
               
               
                   
               
               
                 261 
                 215043_s_at 
                 Cagtctttcccagggaactccgatgaagtgttccaacaaa 
               
               
                   
                   
                 atgagcgagtgaaccaagaagaggatgacattagatccag 
               
               
                   
                   
                 gagatacaacagaggagataatctccaggatgcctgtgaa 
               
               
                   
                   
                 gaaagatccctggatcccaggatgattataggacaagttg 
               
               
                   
                   
                 ttcataatccagcaggccagaagacttccagggaaactca 
               
               
                   
                   
                 tt 
               
               
                   
               
               
                 262 
                 215933_s_at 
                 ggacagttcctgtgatcagaggcaagatttgcccagngaa 
               
               
                   
                   
                 cagaataaaggtgcttctttggatagctctcaatgttcgc 
               
               
                   
                   
                 cctcccctgcctcccaggaagaccttgaatcagagatttc 
               
               
                   
                   
                 agaggattctgatcaggaagtggacattgagggcgataaa 
               
               
                   
                   
                 agctattttaatgctggatgatgaccactggcattggcat 
               
               
                   
                   
                 gttcagaaaactggatttaggaataatgttttgctacaga 
               
               
                   
                   
                 aaatcttcatagaagaactggaaggctatataagaaaggg 
               
               
                   
                   
                 aatcaattctctggtattctggaaacctaaaaatatttgg 
               
               
                   
                   
                 tgcactgctcaattaacaaacctacatggagaccttaatt 
               
               
                   
                   
                 ttgacttaacaaatagtttatgtactgctcttaggttgtt 
               
               
                   
                   
                 ttgataaagtgacattatagtgattaaattctttccnctt 
               
               
                   
                   
                 taaaaaaacagntagtggttttcactatttataaatagga 
               
               
                   
                   
                 ccttcttgaacgacttttctg 
               
               
                   
               
               
                 263 
                 216199_s_at 
                 ctggagtctggggtatgttgtcatagagatgatgactggc 
               
               
                   
                   
                 aaggtttgcacagatgaagaatgaagcctagtagaatatg 
               
               
                   
                   
                 gacttggaaaattctcttaatcactactgtatgtaatatt 
               
               
                   
                   
                 tacataaagactgtgctgagaagcagtataagccttttta 
               
               
                   
                   
                 accttccaagactgaagactgcacaggtgacaagcgtcac 
               
               
                   
                   
                 ttctcctgctgctcctgtttgtctgatgtggcaaaaggcc 
               
               
                   
                   
                 ctctggagggctggtggccacgaggttaaagaagctgcat 
               
               
                   
                   
                 gttaagtgccattactactgtacacggaccatcgcctctg 
               
               
                   
                   
                 tctcctccgtgtctcgcgcgactgagaaccgtgacatcag 
               
               
                   
                   
                 cgtagtgttttgacctttctaggttcaaaagaagttgtag 
               
               
                   
                   
                 tgttatcaggcgtcccataccttgtttttaatctcctgtt 
               
               
                   
                   
                 tgttgagtgcactgactgtgaaacctttaccttttttgtt 
               
               
                   
                   
                 gttgttggcaagctgcaggttt 
               
               
                   
               
               
                 264 
                 216202_s_at 
                 gttcacaaagagttttggtgcttctggaggatatattgga 
               
               
                   
                   
                 ggcaagaaggagctgatagactacctgcgaacacattctc 
               
               
                   
                   
                 atagtgcagtgtatgccacgtcattgtcacctcctgtagt 
               
               
                   
                   
                 ggagcagatcatcacctccatgaagtgcatcatggggc 
               
               
                   
               
               
                 265 
                 216996_s_at 
                 gctgcatactttggatacttgtctaaaacttgatgatact 
               
               
                   
                   
                 gtctatctgagggacatagccttgtcactcccacagctgc 
               
               
                   
                   
                 cgcgggagctgccatcgtcacatacaaatgcaaaggtggc 
               
               
                   
                   
                 agaggtgctgagcagccttctgggaggtgaaggacacttc 
               
               
                   
                   
                 tcaaaggatgtgcacttgccacacaattatcatattgatt 
               
               
                   
                   
                 ttgaaatcagaatggacactaacaggaatcaagtgctacc 
               
               
                   
                   
                 actttctgatgtgatacaacttctgctacagatattcaaa 
               
               
                   
                   
                 gagtagctgtgctatgtgtttccagatctgcttattgttt 
               
               
                   
                   
                 gggttcaagccaccccagaggattccttgctatgaaaatg 
               
               
                   
                   
                 cggcatttgaatgcaatgggttttcatgtgatcttggtca 
               
               
                   
                   
                 ataactgggagatggacaaactagagatggaagatgcagt 
               
               
                   
                   
                 cacatttttgaagactaaaatctattcagtagaagctctt 
               
               
                   
                   
                 cctgttgctg 
               
               
                   
               
               
                 266 
                 217554_at 
                 aatgctcaccaaattcacaggaaagaagtgcctaggtgat 
               
               
                   
                   
                 catttactgctatttactgcttcctggtatggagcaaaat 
               
               
                   
                   
                 tgccctctggtaggtaactacatttctaattagtatgaaa 
               
               
                   
                   
                 ggttctactattttcctttcttttgcttatttccccttaa 
               
               
                   
                   
                 gcacaatttgcagaccctacttctatttaactgatcatac 
               
               
                   
                   
                 ccttttaaatgccttgtcatcatttttcatagttcctgca 
               
               
                   
                   
                 tcctagaaaaaataaaaaatcatttaaaatattccttggt 
               
               
                   
                   
                 gtctagaaaagaaaatttctctaacaatagagatnatcat 
               
               
                   
                   
                 tttgctttctcacttaagctgatctgaatgatgatttggt 
               
               
                   
                   
                 actgcctttatgag 
               
               
                   
               
               
                 267 
                 217682_at 
                 cacgaggtcaatttatggttatcaaataggtttttttttt 
               
               
                   
                   
                 tttttttgagactgagtgtcgctctatagcccaggctgga 
               
               
                   
                   
                 gtgtagtgctcactgcgacttccgcctcctgggttcaant 
               
               
                   
                   
                 gattctcgtgcctcagtctcccgagtagctgggattgtag 
               
               
                   
                   
                 gcgcctgccaccacgcccagctaatttttgtatttgtagt 
               
               
                   
                   
                 agnnatggggtttcatcatgttggcgaagctggtcttgaa 
               
               
                   
                   
                 cacctgacctcaagtgatctgccttagcctcactgcttgc 
               
               
                   
                   
                 ccctangtggtgggattgcaggtgtgagccactgtgctgg 
               
               
                   
                   
                 cctcaaatagtttttatcaaagctacttcaattagtggtt 
               
               
                   
                   
                 agcaaggcttaaagactaattcagtgctttattttgacac 
               
               
                   
                   
                 ttgttcgcaacatgttgctttttttcctgtgtcctatggg 
               
               
                   
                   
                 acctagtcatctgtatgttaga 
               
               
                   
               
               
                 268 
                 217840_at 
                 gccatccagcacgtcatcaattatgacatgccagaggaga 
               
               
                   
                   
                 ttgagaactatgtacaccggattggccgcaccgggcgctc 
               
               
                   
                   
                 gggaaacacaggcatcgccactaccttcatcaacaaagcg 
               
               
                   
                   
                 tgtgatgagtcagtgctgatggacctcaaagcgctgctgc 
               
               
                   
                   
                 tagaagccaagcagaaggtgccgcccgtgctacaggtgct 
               
               
                   
                   
                 gcattgcggggatgagtccatgctggacattggaggagag 
               
               
                   
                   
                 cgcggctgtgccttctgcgggggcctgggtcatcggatca 
               
               
                   
                   
                 ctgactgccccaaactcgaggctatgcagaccaagcaggt 
               
               
                   
                   
                 cagcaacatcggtcgcaaggactacctggcccacagctcc 
               
               
                   
                   
                 atggacttctgagccgacagtcttcccttctctccaagag 
               
               
                   
                   
                 gcctcagtccccaagactgccaccagtctacacatacagc 
               
               
                   
                   
                 agccccctggacagaatcagcatttcagctcagctggcct 
               
               
                   
                   
                 gg 
               
               
                   
               
               
                 269 
                 218229_s_at 
                 gacctcacagacaaagccattgctagaaatgtcattccaa 
               
               
                   
                   
                 tgatcagatctggaaacaggctgccataaccacttttcct 
               
               
                   
                   
                 tcttgtagactcagctcacctgtatatttaaactgttctt 
               
               
                   
                   
                 ggcatcttgaaacacctatttctactcaggtactcattgt 
               
               
                   
                   
                 cctgttactgattcacctttctgatccttttcaaccagtt 
               
               
                   
                   
                 ttcccccaaggggggaaattttacttaacctctagtattt 
               
               
                   
                   
                 gaacaactcaatatttgaattgttgccccatttgctttta 
               
               
                   
                   
                 cctgtactgtattcttggtcatctcaatggcgtctaaac 
               
               
                   
                   
                 ccagctactttgcattccagaagtttccattccctccaat 
               
               
                   
                   
                 tccacctaatttttcatctgtcctagttactggctctttc 
               
               
                   
                   
                 ttcatgtcttatttctcttgctttgggagcttaaaagatt 
               
               
                   
                   
                 ttacaagacctaattttgggttccttccttggagccatag 
               
               
                   
                   
                 ttaccctgccaa 
               
               
                   
               
               
                 270 
                 218356_at 
                 Ctgaaatttccatctggggattaacttctgtctttctggt 
               
               
                   
                   
                 gaacaatatagcaattcacgcattcttcaagcagcaaaag 
               
               
                   
                   
                 ttcccggaacaattagggaagacgtatggtctgaatttat 
               
               
                   
                   
                 ccaggcagtgggtctgctttggtttttgctggaaatttat 
               
               
                   
                   
                 atcagtgtctgggctcc 
               
               
                   
               
               
                 271 
                 218432_at 
                 gaaactatgtgactcattctgtgaaaagacttcttgcagt 
               
               
                   
                   
                 tgtgagttatttagaaatgatcaaaatttgtaattaggct 
               
               
                   
                   
                 aatccatttagtgattcctaatattttgtactcacagaga 
               
               
                   
                   
                 actaattgactaaacaacgaacgctagtggtttgtcct 
               
               
                   
                   
                 tagacaatctgtctttgaatttaaagtctttatcgctaag 
               
               
                   
                   
                 accttgactttaaatttttcatcactacaaccttgaattt 
               
               
                   
                   
                 aatttcaggtcttcaacatgatgaccttggatttaattta 
               
               
                   
                   
                 aagtcttcaacactatgcgctttatcatattattcacaga 
               
               
                   
                   
                 tgcatttttgaaatgtagtatgtaaaagtatgtaacgtgc 
               
               
                   
                   
                 tgtttattaacaaaagattgttcacaacatctcatgtagt 
               
               
                   
                   
                 ttaaatttgtaaatactgcttctgttttgtttctccttta 
               
               
                   
                   
                 tacacttgactgt 
               
               
                   
               
               
                 272 
                 218589_at 
                 gggtaacaatgcctcagaagcctgctttgaaaattttcca 
               
               
                   
                   
                 gaagccacatggaaaacatatctctcaaggattgtaattt 
               
               
                   
                   
                 tcatcgaaatagtgggattttttattcctctaattttaaa 
               
               
                   
                   
                 tgtaacttgttctagtatggtgctaaaaactttaaccaaa 
               
               
                   
                   
                 ccagttacattaagtagaagcaaaataaacaaaactaagg 
               
               
                   
                   
                 ttttaaaaatgatttttgtacatttgatcatattctgttt 
               
               
                   
                   
                 ctgttttgttccttacaatatcaatcttattttatattct 
               
               
                   
                   
                 cttgtgagaacacaaacatttgttaattgctcagtagtgg 
               
               
                   
                   
                 cagcagtaaggacaatgtacccaatcactctctgtattgc 
               
               
                   
                   
                 tgtttccaactgttgttttgaccctatagtttactacttt 
               
               
                   
                   
                 acatcggacacaattcagaattcaataaaaatgaaaaact 
               
               
                   
                   
                 ggtctgtcaggagaagtgacttcagattctctgaagttca 
               
               
                   
                   
                 tggtgcagagaattttattcagcataacctacagacctta 
               
               
                   
                   
                 aaaagtaagatatttgacaatgaatctgctgcctgaa 
               
               
                   
               
               
                 273 
                 218604_at 
                 tttgttttattgtatgcgttgggtttgcagcatgaacttg 
               
               
                   
                   
                 cacagataatgcacgttttctggttaagtaaacatgatgc 
               
               
                   
                   
                 acactattctgtaacagaaagccctattgtgccttacctg 
               
               
                   
                   
                 tgtgctttgtgggcaccttgtttatgaagaataaaaaat 
               
               
                   
                   
                 gatttgttatctgaagagaataaattttaaattctcagtt 
               
               
                   
                   
                 tatgtctcagatgctaacgtgtgaaaatataaatatatat 
               
               
                   
                   
                 aatatataaagtaaccagtcttcctgtattttatgtgcat 
               
               
                   
                   
                 catagtgatttatctgagcttagtgacccccatcttgtaa 
               
               
                   
                   
                 cctgttgcaagagtgaatgtaaaaaatagttgtggcattt 
               
               
                   
                   
                 taaaaggtcgcctttgatgcagatgcatctttttcttgct 
               
               
                   
                   
                 tctaaaacatatttcatgtaaacattgtacatttattatt 
               
               
                   
                   
                 gtaatatatactattatgcagcttattttacctgaaactg 
               
               
                   
                   
                 ttaagccgaccaagatccct 
               
               
                   
               
               
                 274 
                 218689_at 
                 cctgggtgttccacagctgatagtgattgccttgaataaa 
               
               
                   
                   
                 ttcaagggcaatttattcatttttactagggagatagacc 
               
               
                   
                   
                 tttacagcaatcaagatatttttgtccatatccaggttag 
               
               
                   
                   
                 ctggtaagaggatttttttggagaaaaaaaatgatattta 
               
               
                   
                   
                 gaaagttaatttctaattccggaatggaataaaaacaata 
               
               
                   
                   
                 tgagtagtgtaatcttgtagaaaaagagttgtataatctt 
               
               
                   
                   
                 gtagaatttctcattctgtggtacaacccaggggtaaact 
               
               
                   
                   
                 attattccagtagtcagtacacttttctagataaatcttg 
               
               
                   
                   
                 agtgaaaaccagcaatttctttttccttgtggtctgattc 
               
               
                   
                   
                 ctttttctaatccatgaaggccatcttgtagattacattt 
               
               
                   
                   
                 atcattaatgcaagaataaagacaattcctcctgtcagtt 
               
               
                   
                   
                 gcgtgaattttttttaagaaacaacccagtgaagagttct 
               
               
                   
                   
                 accatagcaaggcctaatgttagctttagctttagaaaat 
               
               
                   
                   
                 aacagtttgtgaacttacttccctatatttgcagctgt 
               
               
                   
               
               
                 275 
                 218889_at 
                 gcttgtattcaggttcattggcttttgctggatgatccac 
               
               
                   
                   
                 ctaaagaagttacctaatttggccttttaaaaaaggtgtt 
               
               
                   
                   
                 agtgtttattatagctactttcaaggaaagtttgaatatg 
               
               
                   
                   
                 attctagtctctaaagttcttcacgttttctgacattccc 
               
               
                   
                   
                 tggagggtgactggggaagaattgctccagggtagaagaa 
               
               
                   
                   
                 ccaggcccaagactttaccattctgatctagagacaaagg 
               
               
                   
                   
                 atactcaatgaggagcttttttcccctcttggaacaggta 
               
               
                   
                   
                 aaatgctttttcttattaatataattataaaacagtattt 
               
               
                   
                   
                 tatgtaacagctattcccatattctaggagtggcctaaga 
               
               
                   
                   
                 aatgcgtgtttcagtgactagatta 
               
               
                   
               
               
                 276 
                 218973_at 
                 ctgcaagtgaaacctcagcgcctgatggcagctatgtaca 
               
               
                   
                   
                 catgtgacatcatggccactggtgatgttctcggtcgagt 
               
               
                   
                   
                 ctatgctgtcttgtcaaagagagaaggtcgggtacttcaa 
               
               
                   
                   
                 gaagaaatgaaagaagggacagacatgttcatcatcaagg 
               
               
                   
                   
                 ctgtgctgcctgttgctgaaagctttggttttgctgatga 
               
               
                   
                   
                 aatcaggaagaggacaagtggcctggccagcccacaacta 
               
               
                   
                   
                 gtattcagccattgggagatcattcccagtgaccccttct 
               
               
                   
                   
                 gggtgccaactactgaggaggaatacttgcactttgggga 
               
               
                   
                   
                 gaaggctgactctgagaaccaagcccggaagtacatgaac 
               
               
                   
                   
                 gcagtacgaaagcggaaggggctttatgtggaagaaaaga 
               
               
                   
                   
                 ttgtggagcatgcagaaaagcagaggacactcagcaaaaa 
               
               
                   
                   
                 taagtagctacctactactggtggattcttttccttatag 
               
               
                   
                   
                 tgaatttaaaagtatcatcaagggtttaatattgggaaaa 
               
               
                   
                   
                 tttctttttgccacattatctctgtttattcact 
               
               
                   
               
               
                 277 
                 219069_at 
                 gaatattgtatactgcatcccctaccacaatttacacaat 
               
               
                   
                   
                 cctgtggatagtcctacctcaccctggtcaacctacatga 
               
               
                   
                   
                 tccttaagctaatggcgaatcacgatgaccttgtagacat 
               
               
                   
                   
                 gcacacaactatacctttgtccaacagatcataatatatc 
               
               
                   
                   
                 tgctatccaactggttttacctgcctaatcctactgattt 
               
               
                   
                   
                 gggcactgcttgtatagtctctcaagttcacaggaaatgt 
               
               
                   
                   
                 tgattttctaaggtcctcattt 
               
               
                   
               
               
                 278 
                 219093_at 
                 tagagacccatgtcatcttaacctaaagggaaatcttatt 
               
               
                   
                   
                 gcgttatcataaaattgatgatatcttagggtcagaattg 
               
               
                   
                   
                 cccttttttttattttgaatgggaagctctcactaaaaca 
               
               
                   
                   
                 atcctgagatttcttaatttcatggttctttaaatattat 
               
               
                   
                   
                 aaacacagagtcaacatagaataaaattgtatttgttaaa 
               
               
                   
                   
                 atacacacattggaagacaagagcagatgactacttttcg 
               
               
                   
                   
                 aagtaatgctgctccttcctaaaagtctgttttcaatcct 
               
               
                   
                   
                 ggtaatattaggggcactgcggcacctaagaagccttaaa 
               
               
                   
                   
                 tgagagctaatccaatttagagagcgatggtgtcagcatt 
               
               
                   
                   
                 tcggtctgcatatctgtgtgtccgtatctgcgtttgtgtg 
               
               
                   
                   
                 cgtgtacgtgtgcccctgtgtgtgggcccagttttcaggc 
               
               
                   
                   
                 atgtagaataagcatggagtcatattgaggaggctcact 
               
               
                   
                   
                 tcttgaagat 
               
               
                   
               
               
                 279 
                 219099_at 
                 aatggactgactgaaactcgctaaggttaaatctgcatca 
               
               
                   
                   
                 aaatctaaccaatttgagcctctgaagggagtgccattgg 
               
               
                   
                   
                 ctttatttacttctctcctctgctagtcctgatttggaaa 
               
               
                   
                   
                 cagttaaaagccaatttttagctccagtggaaccatagcc 
               
               
                   
                   
                 acataaaactttaatggacaaccatatagaattaacttat 
               
               
                   
                   
                 tttgtccaagtacagttggcattttccagaataattttac 
               
               
                   
                   
                 caccctgctagatgtcatctctggattgcacatggatgat 
               
               
                   
                   
                 gaaggaactcagcattgaaagttgggggattagtaacctt 
               
               
                   
                   
                 gttacaacggtttctttttcattttagcctattttaatgg 
               
               
                   
                   
                 ctattggtaagatactgtatgtttttagtatctcatccag 
               
               
                   
                   
                 tgcttagaagaaagaatggtttataattcccagtacatgt 
               
               
                   
                   
                 tt 
               
               
                   
               
               
                 280 
                 219176_at 
                 Caacaggaggcatctccatttactatgatgagaaaggaag 
               
               
                   
                   
                 gaagtttgttaacatcctgatgtgcttttggtatctaacc 
               
               
                   
                   
                 agtgccaacatccccagtgaaactttaagaggagccagtg 
               
               
                   
                   
                 tattccaggttaagttggggaatcagaatgtggaaactaa 
               
               
                   
                   
                 acaacttcttagtgcaagctatgagtttcagagggagttc 
               
               
                   
                   
                 acacaaggagtaaagcctgactggaccattgcacggattg 
               
               
                   
                   
                 aacactcaaaattattagaataattttcttggaaaaatca 
               
               
                   
                   
                 gcttatggactttagcagttgctgtgaaaaactaaggaag 
               
               
                   
                   
                 aaaaattttggggtcatttgatcttcacttaatctaagtc 
               
               
                   
                   
                 tgtgaattacttttatattattttgaaatactccttgcag 
               
               
                   
                   
                 tatattggcatgatacagtaaaagcattttccacagattg 
               
               
                   
                   
                 ttatcaccttcttt 
               
               
                   
               
               
                 281 
                 219243_at 
                 tcttctagattctctctatgttggcagataatctcccctt 
               
               
                   
                   
                 gtagcttccactcacttattcttgcattcagagtcacaat 
               
               
                   
                   
                 gatcatcttacccatgtggtttttgagaaagaaagatcaa 
               
               
                   
                   
                 ttctttgtttgcagtgggtaatcttagagatggagatgat 
               
               
                   
                   
                 tgtagaattattcctagatgagtgtcaatttatttaattc 
               
               
                   
                   
                 cattgtcatataaggagtcaaattgtttcttatcatttgt 
               
               
                   
                   
                 tcattgaagaacagagacctgtctggaaaatcgatctcta 
               
               
                   
                   
                 caaattcaattaaataatgatccccaaatgctgaaaaagt 
               
               
                   
                   
                 gaaatacagcaattcaacagataatagagcaatgtttagt 
               
               
                   
                   
                 atattcagctgtatctgtagaaactctttgacgaacctca 
               
               
                   
                   
                 atttaaccaatttgatgaatacccagttctcttcttttct 
               
               
                   
                   
                 agagaaagatagttgcaacctcacctccctcactcaacac 
               
               
                   
                   
                 tttgaatacttattgtttggcaggtcatccacacact 
               
               
                   
               
               
                 282 
                 219363_s_at 
                 tggtcagaaaagcaccatttttgctgaacttttcagtgga 
               
               
                   
                   
                 aagactggataaccagattggattttttcagaaggaactg 
               
               
                   
                   
                 gaacttagtgtgaagaagactagagatctggtagttcgtc 
               
               
                   
                   
                 tcccaaggctgctaactggaagtctggaacccgtgaagga 
               
               
                   
                   
                 aaatatgaaggtttatcgtcttgaacttggttttaaacat 
               
               
                   
                   
                 aacgaaattcaacatatgatcaccagaatcccaaagatgt 
               
               
                   
                   
                 taactgcaaataaaatgaaacttaccgagacgtttgattt 
               
               
                   
                   
                 tgtgcacaatgtgatgagcattccccaccacatcattgtca 
               
               
                   
                   
                 agttcccacaggtatttaatacaaggctgtttaaggtca 
               
               
                   
                   
                 aagaaagacacttgtttcttacctatttaggaagagcaca 
               
               
                   
                   
                 gtatgatccagcaaaacctaactacatctctttggacaaa 
               
               
                   
                   
                 ctagtatctattcctgatgaaatattttgtgaagagattg 
               
               
                   
                   
                 ccaaagcatcagtacaggact 
               
               
                   
               
               
                 283 
                 219434_at 
                 ccatgatcatggtttactgcgcgtccgaatggtcaacctt 
               
               
                   
                   
                 caagtggaagattctggactgtatcagtgtgtgatctacc 
               
               
                   
                   
                 agcctcccaaggagcctcacatgctgttcgatcgcatccg 
               
               
                   
                   
                 cttggtggtgaccaagggtttttcagggacccctggctcc 
               
               
                   
                   
                 aatgagaattctacccagaatgtgtataagattcctccta 
               
               
                   
                   
                 ccaccactaaggccttgtgcccactctataccagccccag 
               
               
                   
                   
                 aactgtgacccaagctccacccaagtcaactgccgatgtc 
               
               
                   
                   
                 tccactcctgactctgaaatcaaccttacaaatgtgacag 
               
               
                   
                   
                 atatcatcagggttccggtgttcaacattgtcattctcct 
               
               
                   
                   
                 ggctggtggattcctgagtaagagcctggtcttctctgtc 
               
               
                   
                   
                 ctgtttgctgtcacgctgaggtcatttgtaccctaggccc 
               
               
                   
                   
                 acgaacccacgagaatgtcctctgact 
               
               
                   
               
               
                 284 
                 221485_at 
                 aatgtgaccttgtgcatatattggtagctgaaaatcttca 
               
               
                   
                   
                 aggctactgatgggtggccccttaatcttgtctttgattg 
               
               
                   
                   
                 ctgtgtgcagggaaaggtgtccccgtttgttcatgctgtt 
               
               
                   
                   
                 ttggggggtgggggggtatttgcaagaatactcattttga 
               
               
                   
                   
                 cataataggtcctcttgtcagagatcctctaccacagaca 
               
               
                   
                   
                 ttaatagctgagcaggagccacatggattgattgtatcca 
               
               
                   
                   
                 ctcaccattgacgatggcattgagcgtagctagcttattt 
               
               
                   
                   
                 ccatcactacgtgtttttgagcttgctcttacgttttaag 
               
               
                   
                   
                 aggtgccaggggtacatttttgcactgaaatcta 
               
               
                   
               
               
                 285 
                 221652_s_at 
                 ggccagtgtcgttattatccttgtggagaatagaatcaat 
               
               
                   
                   
                 actgccaattccagaaaacatcaggaatttgctggacgtt 
               
               
                   
                   
                 tgaactctgttaataacagagctgaactatatcaacatct 
               
               
                   
                   
                 taaagaggaaaatgggatggagacaacagaaaatggaaaa 
               
               
                   
                   
                 gccagccggcagtgaagagtgacttgaagaactaaattta 
               
               
                   
                   
                 gcatattgcaaaaatattttgtgcggaattcgatataagt 
               
               
                   
                   
                 acttttacagcaagatggtatagttatgttgcctggactg 
               
               
                   
                   
                 gtttttacatttttaaaatatttcagctgtcatttttgta 
               
               
                   
                   
                 ctaattataaaattggcacataattcaaaaatatacattt 
               
               
                   
                   
                 gagatgatttgtcctcccaaattatacaagtttattttat 
               
               
                   
                   
                 ggtataaagtgttctctctggaaatgtttttaaaaaaatt 
               
               
                   
                   
                 cttaggcttctctttgcgaaataaa 
               
               
                   
               
               
                 286 
                 221755_at 
                 Ggagcctcatggagtcaggtgccaacaagctgcaggagga 
               
               
                   
                   
                 ggtgctgatccaggagtggttcaccctggtcaacaagaag 
               
               
                   
                   
                 nacgctctcatcnnnanncannnccngcnncnnnnnnnca 
               
               
                   
                   
                 tggaggagcaggacttggagcgaaggttcgagctgctgag 
               
               
                   
                   
                 ccgcgagctgcgggccatgctggccatcgaagactggcag 
               
               
                   
                   
                 aaaacgtccgctcagcagcaccgagagcagatcctactgg 
               
               
                   
                   
                 aggagctggtgtcgctggtgaaccagcgcgatgagctagt 
               
               
                   
                   
                 ccgggacctggaccacaaggagcggatcgccctggaggag 
               
               
                   
                   
                 gacgagcgcctggagcgcggcctggaacagcggcgccgca 
               
               
                   
                   
                 agctgagccggcagttgagccggcgggagcgc 
               
               
                   
               
               
                 287 
                 221970_s_at 
                 gcgaaaatgctactatgactcttcctggaatacacccacc 
               
               
                   
                   
                 taccttgaaccagattatggattggatatgtctacttctg 
               
               
                   
                   
                 gatgcgaattttactgttgtngtaatgatgccagaagcaa 
               
               
                   
                   
                 agaggctactgataaatctttacaagcttgtaaaatctca 
               
               
                   
                   
                 gatatctgtttattctgagctcaacaagattgaagtaagt 
               
               
                   
                   
                 tttcgggagctacagaaattaaatcaagaaaagaataata 
               
               
                   
                   
                 gaggattatattcaattgaagtgctggagctcttctgata 
               
               
                   
                   
                 ttatcaattctccttcatagacattttataaagctctttt 
               
               
                   
                   
                 atgtgaactcttgcttcatccaggcaagaacggtgttttg 
               
               
                   
                   
                 tttgcgaccatctcagtgtcaagagaaacgtgtcagtgag 
               
               
                   
                   
                 tacctggaccatcacttaactgatgctccggggtaggact 
               
               
                   
                   
                 gcaggtttcacatgaacctgttntaggctgtggacattgg 
               
               
                   
                   
                 tgtggaga 
               
               
                   
               
               
                 288 
                 222127_s_at 
                 ctcgctgttatcctggatctggtgttacaatggaattcac 
               
               
                   
                   
                 tattcaggacattctggattattgttccagcattgcacag 
               
               
                   
                   
                 tcccactaaaccttgtgaaagaagaaaagataactgaatg 
               
               
                   
                   
                 aagcatttgagtataacagacactataccaaaataccaag 
               
               
                   
                   
                 caactgttttgagaacccagacttaaaattttatgtatta 
               
               
                   
                   
                 ttaaatgttagataaatgggtagtaccatactacaaatat 
               
               
                   
                   
                 ttaaatgcaaaattaccaacctatatagcagttttatttg 
               
               
                   
                   
                 ccctataggttgcatactaacttaagcattcatgtcacca 
               
               
                   
                   
                 taaaatgcctttagcatttctcaatgactggatgggaaat 
               
               
                   
                   
                 tttcctttattgcctagctgcttgtgtttgagtggttgtc 
               
               
                   
                   
                 ctatgagcaatgcatttggagttcttcagctttcactact 
               
               
                   
                   
                 tctctgttgcttgctaatcatg 
               
               
                   
               
               
                 289 
                 36711_at 
                 ttgcacggatctaagttattctccccagccagagcccgng 
               
               
                   
                   
                 ctnnctgctcccngggaaaagntggcgtantggncctgag 
               
               
                   
                   
                 ctgggntttatattttatatctgcaaataaatnacatttt 
               
               
                   
                   
                 atcntanatttagggaaagccngagagnaacaacaaaaaa 
               
               
                   
                   
                 tgtttaagccnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnnnntattgcccggctcct 
               
               
                   
                   
                 agaatttatttatttcctgacttacagcaagcgagttatc 
               
               
                   
                   
                 gtcttctgtattttg 
               
               
                   
               
               
                 290 
                 38037_at 
                 ccactctatgagttggacttcagtcttgcctaggcgattt 
               
               
                   
                   
                 tgtctaccatttgtgttttgaaagcccaaggtgctgatgt 
               
               
                   
                   
                 caaagtgtaacagatatcagtgtctccccgtgtcctctcc 
               
               
                   
                   
                 ctgncaagtctcagaagaggttgggcttccatgcctgtag 
               
               
                   
                   
                 ctttcctggtccctcacccccatngccccaggcccacagc 
               
               
                   
                   
                 gtgggaactcactttcccttgtgtcaagacatttctnnnn 
               
               
                   
                   
                 nnnnnnnnnnnnnnnnnnnnnnactccatgcaggggtcag 
               
               
                   
                   
                 tgcagcagaggacagtctggagaaggtattagcaaagcaa 
               
               
                   
                   
                 aaggctgagaaggaacagggaacattggagctgactgttc 
               
               
                   
                   
                 ttggtaactgattacctgccaattgctaccgagaaggttg 
               
               
                   
                   
                 gaggtggggaaggctttgtataatcccacccacctcacca 
               
               
                   
                   
                 aaacgannnnnnnnnnnnnnnnnngtcctttctggaagtt 
               
               
                   
                   
                 tctggtgccatttc 
               
               
                   
               
               
                 291 
                 AFFX-BioB-M_at 
                 gccggagttttacggcaatatcatcaccacacgcacttat 
               
               
                   
                   
                 caggaacgcctcgatacgctggaaaaagtgcgcgatgccg 
               
               
                   
                   
                 ggatcaaagtctgttctggcggcattgtgggcttaggcga 
               
               
                   
                   
                 aacggtaaaagatcgcgccggattattgctgcaactggca 
               
               
                   
                   
                 aacctgccgacgccgccggaaagcgtgccaatcaacatgc 
               
               
                   
                   
                 tggtgaaggtgaaaggcacgccgcttgccgataacgatga 
               
               
                   
                   
                 tgtcgatgcctttgattt 
               
               
                   
               
               
                 292 
                 AFFX-r2-Ec-bioC- 
                 cgctggtgcagggatcgttacccgaacgtcatcaggcgtg 
               
               
                   
                 3_at 
                 gcaggcggtggacgagcgtccgcatgctaatcgcttttta 
               
               
                   
                   
                 ccgccagatgaaatcgaacagtcgctgaacggcgtgcatt 
               
               
                   
                   
                 atcaacatcatattcagcccatcacgctgtggtttgatga 
               
               
                   
                   
                 tgcgctcagtgccatgcgttcgctgaaaggcatcggtgcc 
               
               
                   
                   
                 acgcatcttcatgaagggcgcgacccgcgaatattaacgc 
               
               
                   
                   
                 gttcgcagttgcagcgattgcaactggcctggccgc 
               
               
                   
               
               
                 293 
                 204018_x_at 
                 ggtccccacagactcagagagaacccaccatggtgctgtc 
               
               
                   
                   
                 tcctgccgacaagaccaacgtcaaggccgcctggggtaag 
               
               
                   
                   
                 gtcggcgcgcacgctggcgagtatggtgcggaggccctgg 
               
               
                   
                   
                 agaggatgttcctgtccttccccaccaccaagacctactt 
               
               
                   
                   
                 cccgcacttcgacctgagccacggctctgcccaggttaag 
               
               
                   
                   
                 ggccacggcaagaaggtggccgacgccctgaccaacgccg 
               
               
                   
                   
                 tggcgcacgtggacgacatgcccaacgcgctgtccgccct 
               
               
                   
                   
                 gagcgacctgcacgcgcacaagcttcgggtggacccggtc 
               
               
                   
                   
                 aacttcaagctcctaagccactgcctgctggtgaccctgg 
               
               
                   
                   
                 ccgcccacctccccgccgagttcacccctgcggtgcacgc 
               
               
                   
                   
                 ctccctggacaagttcctggcttctgtgagcaccgtgctg 
               
               
                   
                   
                 acctccaaataccgttaagctg 
               
               
                   
               
               
                 294 
                 222043_at 
                 tcgactctgctgctcatgggaagaacagaattgctcctgc 
               
               
                   
                   
                 atgcaactaattcaataaaactgtcttgtgagctgatcgc 
               
               
                   
                   
                 ttggagggtcctctttttatgttgagttgctgcttcccgg 
               
               
                   
                   
                 catgccttcattttgctatggggggcaggcaggggggatg 
               
               
                   
                   
                 gaaaataagtagaaacaaaaaagcagtggctaagatggta 
               
               
                   
                   
                 tagggactgtcataccagtgaagaataaaagggtgaagaa 
               
               
                   
                   
                 taaaagggatatgatgacaaggttgatccacttcaagaat 
               
               
                   
                   
                 tgcttgctttcaggaagagagatgtgtttcaacaagccaa 
               
               
                   
                   
                 cta 
               
               
                   
               
               
                 295 
                 206026_s_at 
                 Tacaagtactacttctactggaaataaaaactttttagct 
               
               
                   
                   
                 ggaagatttagccacttataaaaaaaaaaaaggatgatca 
               
               
                   
                   
                 aaacacacagtgtttatgttggaatcttttggaactcctt 
               
               
                   
                   
                 tgatctcactgttattattaacatttatttattatttttc 
               
               
                   
                   
                 taaatgtgaaagaaatacataatttagggaaaattggaaa 
               
               
                   
                   
                 atataggaaactttaaacgagaaaatgaaacctctcataa 
               
               
                   
                   
                 tcccactgcatagaaataacaagcgttaacattttcatat 
               
               
                   
                   
                 ttttttctttcagtcatttttgtatttgtggtatatgtat 
               
               
                   
                   
                 atatgtacctatatgtatttgcatttgaaattttggaatc 
               
               
                   
                   
                 ctgctctatgtacagttttgtattatactttttaaatctt 
               
               
                   
                   
                 gaactttatgaacattttctgaaatcattgattattctac 
               
               
                   
                   
                 aaaaacatgattttaaacagctgtaaaatattctatgata 
               
               
                   
                   
                 tgaatgttttatgcattatttaagcctgtctctattgttg 
               
               
                   
                   
                 gaatttcaggtcattttcat 
               
               
                   
               
               
                 296 
                 208894_at 
                 cgatcaccaatgtacctccagaggtaactgtgctcacgaa 
               
               
                   
                   
                 cagccctgtggaactgagagagcccaacgtcctcatctgt 
               
               
                   
                   
                 ttcatagacaagttcacccca 
               
               
                   
               
               
                 297 
                 222150_s_at 
                 taatcttgctcattaaccttactcctttgagaattcttta 
               
               
                   
                   
                 acaatatttaaaattggtaacaaaaatagtttagccataa 
               
               
                   
                   
                 ttgtttagccatgtgagtttcaggttggtacacgttcaga 
               
               
                   
                   
                 cagaactgctgtatcacattccaattttgaatagccagtg 
               
               
                   
                   
                 agcaatcaagtgtagagaaatgataaatggcctaagaagg 
               
               
                   
                   
                 catacagtggcataaacgatgctcttcctagtagcttaat 
               
               
                   
                   
                 aggccacaagctagtttctgttgccctctgaaataaaata 
               
               
                   
                   
                 tgctttaaaaatgtagggaccagtgcttagaaaagcaaaa 
               
               
                   
                   
                 actaggtgtgtcattgaaataataggcataaaaattaaat 
               
               
                   
                   
                 gttacataagacccctatttggaaaaagggtccttttaaa 
               
               
                   
                   
                 aactgaatttgtactaaatcagatttgccatgtccagtac 
               
               
                   
                   
                 agaataatttgtacttagtatttgcagcagggtttgtctt 
               
               
                   
                   
                 tgtgaattcag 
               
               
                   
               
               
                 298 
                 207113_s_at 
                 ccagaactcactggggcctacagctttgatccctgacatc 
               
               
                   
                   
                 tggaatctggagaccagggagcctttggttctggccagaa 
               
               
                   
                   
                 tgctgcaggacttgagaagacctcacctagaaattgacac 
               
               
                   
                   
                 aagtggaccttaggccttcctctctccagatgtttccaga 
               
               
                   
                   
                 cttccttgagacacggagcccagccctccccatggagcca 
               
               
                   
                   
                 gctccctctatttatgtttgcacttgtgattatttattat 
               
               
                   
                   
                 ttatttattatttatttatttacagatgaatgtatttatt 
               
               
                   
                   
                 tgggagaccggggtatcctgggggacccaatgtaggagct 
               
               
                   
                   
                 gccttggctcagacatgttttccgtgaaaacggaggctga 
               
               
                   
                   
                 acaataggctgttcccatgtagccccctggcctctgtgcc 
               
               
                   
                   
                 ttcttttgattatgttttttaaaatattatctgattaagt 
               
               
                   
                   
                 tgtctaaacaatgctgatttggtgaccaactgtcactcat 
               
               
                   
                   
                 tgctg 
               
               
                   
               
               
                 299 
                 205067_at 
                 agctgtacccagagagtcctgtgctgaatgtggactcaat 
               
               
                   
                   
                 ccctagggctggcagaaagggaacagaaaggtttttgagt 
               
               
                   
                   
                 acggctatagcctggactttcctgttgtctacaccaatgc 
               
               
                   
                   
                 ccaactgcctgccttagggtagtgctaagaggatctcctg 
               
               
                   
                   
                 tccatcagccaggacagtcagctctctcctttcagggcca 
               
               
                   
                   
                 atccccagcccttttgttgagccaggcctctctcacctct 
               
               
                   
                   
                 cctactcacttaaagcccgcctgacagaaaccacggccac 
               
               
                   
                   
                 atttggttctaagaaaccctctgtcattcgctcccacatt 
               
               
                   
                   
                 ctgatgagcaaccgcttccctatttatttatttatttgtt 
               
               
                   
                   
                 tgtttgttttattcattggtctaatttattcaaagggggc 
               
               
                   
                   
                 aagaagtagcagtgtctgtaaaagagcctagtttttaata 
               
               
                   
                   
                 gctatggaatcaattcaatttggactggtgtgctctcttt 
               
               
                   
                   
                 aaatcaagtcc 
               
               
                   
               
               
                 300 
                 201290_at 
                 gaacacacgtgttggtgcttctgggtagcactggtttgca 
               
               
                   
                   
                 ttagtttatgtttccatgccagagtttgtgtgggccgggcg 
               
               
                   
                   
                 catgtgcaccacagagtgcactcgaggggactttcagtca 
               
               
                   
                   
                 caggatttcataattgtcattgtcacactttcaaattttt 
               
               
                   
                   
                 gtacatcagtgaatttttttatattaaaaggttgagccaa 
               
               
                   
                   
                 aaagcccccagtgtttgtattttgaagccaagcttcactt 
               
               
                   
                   
                 ctaaagtgcctacagagacttgtaaatgaaaatgcagctc 
               
               
                   
                   
                 tgcacgactttgaaaccgtcatacctccttctattaggaa 
               
               
                   
                   
                 tggcatatactgaggtggtcgtaagtcttaacttct 
               
               
                   
               
               
                 301 
                   
                 agtaccttggtccagctcttcctgcaacggcccaggagct 
               
               
                 CD11c 
                   
                 cagagctccacatctgaccttctagtcatgaccaggacca 
               
               
                 full-length n.t. 
                   
                 gggcagcactcctcctgttcacagccttagcaacttctct 
               
               
                   
                   
                 aggtttcaacttggacacagaggagctgacagccttccgt 
               
               
                   
                   
                 gtggacagcgctgggtttggagacagcgtggtccagtatg 
               
               
                   
                   
                 ccaactcctgggtggtggttggagccccccaaaagataac 
               
               
                   
                   
                 agctgccaaccaaacgggtggcctctaccagtgtggctac 
               
               
                   
                   
                 agcactggtgcctgtgagcccatcggcctgcaggtgcccc 
               
               
                   
                   
                 cggaggccgtgaacatgtccctgggcctgtccctggcgtc 
               
               
                   
                   
                 taccaccagcccttcccagctgctggcctgcggccccacc 
               
               
                   
                   
                 gtgcaccacgagtgcgggaggaacatgtacctcaccggac 
               
               
                   
                   
                 tctgcttcctcctgggccccacccagctcacccagaggct 
               
               
                   
                   
                 cccggtgtccaggcaggagtgcccaagacaggagcaggac 
               
               
                   
                   
                 attgtgttcctgatcgatggctcaggcagcatctcctccc 
               
               
                   
                   
                 gcaactttgccacgatgatgaacttcgtgagagctgtgat 
               
               
                   
                   
                 aagccagttccagagacccagcacccagttttccctgatg 
               
               
                   
                   
                 cagttctccaacaaattccaaacacacttcactttcgagg 
               
               
                   
                   
                 aattcaggcgcagctcaaaccccctcagcctgttggcttc 
               
               
                   
                   
                 tgttcaccagctgcaagggtttacatacacggccaccgcc 
               
               
                   
                   
                 atccaaaatgtcgtgcaccgattgttccatgcctcatatg 
               
               
                   
                   
                 gggcccgtagggatgccgccaaaattctcattgtcatcac 
               
               
                   
                   
                 tgatgggaagaaagaaggcgacagcctggattataaggat 
               
               
                   
                   
                 gtcatccccatggctgatgcagcaggcatcatccgctatg 
               
               
                   
                   
                 caattggggttggattagcttttcaaaacagaaattcttg 
               
               
                   
                   
                 gaaagaattaaatgacattgcatcgaagccctcccaggaa 
               
               
                   
                   
                 cacatatttaaagtggaggactttgatgctctgaaagata 
               
               
                   
                   
                 ttcaaaaccaactgaaggagaagatctttgccattgaggg 
               
               
                   
                   
                 tacggagaccacaagcagtagctccttcgaattggagatg 
               
               
                   
                   
                 gcacaggagggcttcagcgctgtgttcacacctgatggcc 
               
               
                   
                   
                 ccgttctgggggctgtggggagcttcacctggtctggagg 
               
               
                   
                   
                 tgccttcctgtaccccccaaatatgagccctaccttcatc 
               
               
                   
                   
                 aacatgtctcaggagaatgtggacatgagggactcttacc 
               
               
                   
                   
                 tgggttactccaccgagctggccctctggaaaggggtgca 
               
               
                   
                   
                 gagcctggtcctgggggccccccgctaccagcacaccggg 
               
               
                   
                   
                 aaggctgtcatcttcacccaggtgtccaggcaatggagga 
               
               
                   
                   
                 tgaaggccgaagtcacggggactcagatcggctcctactt 
               
               
                   
                   
                 cggggcctccctctgctccgtggacgtagacagcgacggc 
               
               
                   
                   
                 agcaccgacctggtcctcatcggggccccccattactacg 
               
               
                   
                   
                 agcagacccgagggggccaggtgtctgtgtgtcccttgcc 
               
               
                   
                   
                 cagggggtggagaaggtggtggtgtgatgctgttctctac 
               
               
                   
                   
                 ggggagcagggccacccctggggtcgctttggggcggctc 
               
               
                   
                   
                 tgacagtgctgggggatgtgaatggggacaagctgacaga 
               
               
                   
                   
                 cgtggtcatcggggccccaggagaggaggagaaccggggt 
               
               
                   
                   
                 gctgtctacctgtttcacggagtcttgggacccagcatca 
               
               
                   
                   
                 gcccctcccacagccagcggatcgcgggctcccagctctc 
               
               
                   
                   
                 ctccaggctgcagtattttgggcaggcactgagcgggggt 
               
               
                   
                   
                 caagacctcacccaggatggactggtggacctggctgtgg 
               
               
                   
                   
                 gggcccggggccaggtgctcctgctcaggaccagacctgt 
               
               
                   
                   
                 gctctgggtgggggtgagcatgcagttcatacctgccgag 
               
               
                   
                   
                 atccccaggtctgcgtttgagtgtcgggagcaggtggtct 
               
               
                   
                   
                 ctgagcagaccctggtacagtccaacatctgcctttacat 
               
               
                   
                   
                 tgacaaacgttctaagaacctgcttgggagccgtgacctc 
               
               
                   
                   
                 caaagctctgtgaccttggacctggccctcgaccctggcc 
               
               
                   
                   
                 gcctgagtccccgtgccaccttccaggaaacaaagaaccg 
               
               
                   
                   
                 gagtctgagccgagtccgagtcctcgggctgaaggcacac 
               
               
                   
                   
                 tgtgaaaacttcaacctgctgctcccgagctgcgtggagg 
               
               
                   
                   
                 actctgtgacccccattaccttgcgtctgaacttcacgct 
               
               
                   
                   
                 ggtgggcaagcccctccttgccttcagaaacctgcggcct 
               
               
                   
                   
                 atgctggccgccgatgctcagagatacttcacggcctccc 
               
               
                   
                   
                 taccctttgagaagaactgtggagccgaccatatctgcca 
               
               
                   
                   
                 ggacaatctcggcatctccttcagcttcccaggcttgaag 
               
               
                   
                   
                 tccctgctggtggggagtaacctggagctgaacgcagaag 
               
               
                   
                   
                 tgatggtgtggaatgacggggaagactcctacggaaccac 
               
               
                   
                   
                 catcaccttctcccaccccgcaggactgtcctaccgctac 
               
               
                   
                   
                 gtggcagagggccagaaacaagggcagctgcgttccctgc 
               
               
                   
                   
                 acctgacatgtgacagcgccccagttgggagccagggcac 
               
               
                   
                   
                 ctggagcaccagctgcagaatcaaccacctcatcttccgt 
               
               
                   
                   
                 ggcggcgcccagatcaccttcttggctacctttgacgtct 
               
               
                   
                   
                 cccccaaggctgtcctgggagaccggctgcttctgacagc 
               
               
                   
                   
                 caatgtgagcagtgagaacaacactcccaggaccagcaag 
               
               
                   
                   
                 accaccttccagctggagctcccggtgaagtatgctgtct 
               
               
                   
                   
                 acactgtggttagcagccacgaacaattcaccaaatacct 
               
               
                   
                   
                 caacttctcagagtctgaggagaaggaaagccatgtggcc 
               
               
                   
                   
                 atgcacagataccaggtcaataacctgggacagagggacc 
               
               
                   
                   
                 tgcctgtcagcatcaacttctgggtgcctgtggagctgaa 
               
               
                   
                   
                 ccaggaggctgtgtggatggatgtggaggtctcccacccc 
               
               
                   
                   
                 cagaacccatcccttcggtgctcctcagagaaaatcgcac 
               
               
                   
                   
                 ccccagcatctgacttcctggcgcacattcagaagaatcc 
               
               
                   
                   
                 cgtgctggactgctccattgctggctgcctgcggttccgc 
               
               
                   
                   
                 tgtgacgtcccctccttcagcgtccaggaggagctggatt 
               
               
                   
                   
                 tcaccctgaagggcaacctcagctttggctgggtccgcca 
               
               
                   
                   
                 gatattgcagaagaaggtgtcggtcgtgagtgtggctgaa 
               
               
                   
                   
                 attacgttcgacacatccgtgtactcccagcttccaggac 
               
               
                   
                   
                 aggaggcatttatgagagctcagacgacaacggtgctgga 
               
               
                   
                   
                 gaagtacaaggtccacaaccccacccccctcatcgtaggc 
               
               
                   
                   
                 agctccattgggggtctgttgctgctggcactcatcacag 
               
               
                   
                   
                 cggtactgtacaaagttggcttcttcaagcgtcagtacaa 
               
               
                   
                   
                 ggaaatgatggaggaggcaaatggacaaattgccccagaa 
               
               
                   
                   
                 aacgggacacagacccccagcccgcccagtgagaaatgat 
               
               
                   
                   
                 cccctctttgccttggacttcttctcccccgcgagttttc 
               
               
                   
                   
                 cccacttacttaccctcacctgtcaggcctgacggggagg 
               
               
                   
                   
                 aaccactgcaccaccgagagaggctgggatgggcctgctt 
               
               
                   
                   
                 cctgtctttgggagaaaacgtcttgcttgggaaggggcct 
               
               
                   
                   
                 ttgtcttgtcaaggttccaactggaaacccttaggacagg 
               
               
                   
                   
                 gtccctgctgtgttccccaaaggacttgacttgcaatttc 
               
               
                   
                   
                 tacctagaaatacatggacaatacccccaggcctcagtct 
               
               
                   
                   
                 cccttctcccatgaggcacgaatgatctttctttcctttc 
               
               
                   
                   
                 tttttttttttttttcttttcttttttttttttttgagac 
               
               
                   
                   
                 ggagtctcgctctgtcacccaggctggagtgcaatggcgt 
               
               
                   
                   
                 gatctcggctcactgcaacctccgcctcccgggttcaagt 
               
               
                   
                   
                 aattctgctgtctcagcctcctgagtagctgggactacag 
               
               
                   
                   
                 gcacacgccacctcgcccggcccgatctttctaaaataca 
               
               
                   
                   
                 gttctgaatatgctgctcatccccacctgtcttcaacagc 
               
               
                   
                   
                 tccccattaccctcaggacaatgtctgaactctccagctt 
               
               
                   
                   
                 cgcgtgagaagtccccttccatcccagagggtgggcttca 
               
               
                   
                   
                 gggcgcacagcatgagaggctctgtgcccccatcaccctc 
               
               
                   
                   
                 gtttccagtgaattagtgtcatgtcagcatcagctcaggg 
               
               
                   
                   
                 cttcatcgtggggctctcagttccgatttcccaggctgaa 
               
               
                   
                   
                 ttgggagtgagatgcctgcatgctgggttctgcacagctg 
               
               
                   
                   
                 gcctcccgcgttgggcaacattgctggctggaagggagga 
               
               
                   
                   
                 gcgccctctagggagggacatggccccggtgcggctgcag 
               
               
                   
                   
                 ctcacccagccccaggggcagaagagacccaaccacttct 
               
               
                   
                   
                 attttttgaggctatgaatatagtacctgaaaaaatgcca 
               
               
                   
                   
                 agacatgattatttttttaaaaagcgtactttaaatgttt 
               
               
                   
                   
                 gtgttaataaattaaaacatgcacaaaaagatgcatctac 
               
               
                   
                   
                 cgctcttgggaaatatgtcaaaggtctaaaaataaaaaag 
               
               
                   
                   
                 ccttctgtgaaaaaaaaaaaaaaaaa 
               
               
                   
               
               
                 302 
                   
                 mtrtraalllftalatslgfnldteeltafrvds 
               
               
                 CD11c 
                   
                 agfgdsvvqyanswvvvgapqkitaanqtgglyq 
               
               
                 full-length a.a. 
                   
                 cgystgacepiglqvppeavnmslglslasttsp 
               
               
                   
                   
                 sqllacgptvhhecgrnmyltglcfllgptqltq 
               
               
                   
                   
                 rlpvsrqecprqeqdivflidgsgsissrnfatm 
               
               
                   
                   
                 mnfvravisqfqrpstqfslmqfsnkfqthftfe 
               
               
                   
                   
                 efrrssnplsllasvhqlqgftytataiqnvvhr 
               
               
                   
                   
                 lfhasygarrdaakilivitdgkkegdsldykdv 
               
               
                   
                   
                 ipmadaagiiryaigvglafqnrnswkelndias 
               
               
                   
                   
                 kpsqehifkvedfdalkdiqnqlkekifaiegte 
               
               
                   
                   
                 ttssssfelemaqegfsavftpdgpvlgavgsft 
               
               
                   
                   
                 wsggaflyppnmsptfinmsqenvdmrdsylgys 
               
               
                   
                   
                 telalwkgvqslvlgapryqhtgkaviftqvsrq 
               
               
                   
                   
                 wrmkaevtgtqigsyfgaslcsvdvdsdgstdlv 
               
               
                   
                   
                 ligaphyyeqtrggqvsvcplprgwrrwwcdavl 
               
               
                   
                   
                 ygeqghpwgrfgaaltvlgdvngdkltdvvigap 
               
               
                   
                   
                 geeenrgavylfhgvlgpsispshsqriagsqls 
               
               
                   
                   
                 srlqyfgqalsggqdltqdglvdlavgargqvll 
               
               
                   
                   
                 lrtrpvlwvgvsmqfipaeiprsafecreqvvse 
               
               
                   
                   
                 qtlvqsniclyidkrsknllgsrdlqssvtldla 
               
               
                   
                   
                 ldpgrlspratfqetknrslsrvrvlglkahcen 
               
               
                   
                   
                 fnlllpscvedsvtpitlrlnftlvgkpllafrn 
               
               
                   
                   
                 lrpmlaadaqryftaslpfekncgadhicqdnlg 
               
               
                   
                   
                 isfsfpglksllvgsnlelnaevmvwndgedsyg 
               
               
                   
                   
                 ttitfshpaglsyryvaegqkqgqlrslhltcds 
               
               
                   
                   
                 apvgsqgtwstscrinhlifrggaqitflatfdv 
               
               
                   
                   
                 spkavlgdrllltanvssenntprtskttfqlel 
               
               
                   
                   
                 pvkyavytvvssheqftkylnfseseekeshvam 
               
               
                   
                   
                 hryqvnnlgqrdlpvsinfwvpvelnqeavwmdv 
               
               
                   
                   
                 evshpqnpslrcssekiappasdflahiqknpvl 
               
               
                   
                   
                 dcsiagclrfrcdvpsfsvqeeldftlkgnlsfg 
               
               
                   
                   
                 wvrqilqkkvsvvsvaeitfdtsvysqlpgqeaf 
               
               
                   
                   
                 mraqtttvlekykvhnptplivgssiggllllal 
               
               
                   
                   
                 itavlykvgffkrqykemmeeangqiapengtqt 
               
               
                   
                   
                 psppsek 
               
               
                   
               
               
                 303 
                   
                 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser 
               
               
                 Adalimumab V L   
                   
                 Leu Ser Ala Ser Val Gly Asp Arg Val Thr 
               
               
                   
                   
                 Ile Thr Cys Arg Ala Ser Gln Gly Ile Arg 
               
               
                   
                   
                 Asn Tyr Leu Ala Trp Tyr Gln Gln Lys Pro 
               
               
                   
                   
                 Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala 
               
               
                   
                   
                 Ala Ser Thr Leu Gln Ser Gly Val Pro Ser 
               
               
                   
                   
                 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp 
               
               
                   
                   
                 Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
               
               
                   
                   
                 Glu Asp Val Ala Thr Tyr Tyr Cys Gln Arg 
               
               
                   
                   
                 Tyr Asn Arg Ala Pro Tyr Thr Phe Gly Gln 
               
               
                   
                   
                 Gly Thr Lys Val Glu Ile Lys 
               
               
                   
               
               
                 304 
                   
                 Glu Val Gln Leu Val Glu Ser Gly Gly Gly 
               
               
                 Adalimumab V H   
                   
                 Leu Val Gln Pro Gly Arg Ser Leu Arg Leu 
               
               
                   
                   
                 Ser Cys Ala Ala Ser Gly Phe Thr Phe Asp 
               
               
                   
                   
                 Asp Tyr Ala Met His Trp Val Arg Gln Ala 
               
               
                   
                   
                 Pro Gly Lys Gly Leu Glu Trp Val Ser Ala 
               
               
                   
                   
                 Ile Thr Trp Asn Ser Gly His Ile Asp Tyr 
               
               
                   
                   
                 Ala Asp Ser Val Glu Gly Arg Phe Thr Ile 
               
               
                   
                   
                 Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 
               
               
                   
                   
                 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 
               
               
                   
                   
                 Thr Ala Val Tyr Tyr Cys Ala Lys Val Ser 
               
               
                   
                   
                 Tyr Leu Ser Thr Ala Ser Ser Leu Asp Tyr 
               
               
                   
                   
                 Trp Gly Gln Gly Thr Leu Val Thr Val Ser 
               
               
                   
                   
                 Ser 
               
               
                   
               
               
                 305 
                   
                 Gln Arg Tyr Asn Arg Ala Pro Tyr Xaa 
               
               
                 Adalimumab 
                   
                 Xaa = Thr or Ala 
               
               
                 V L  CDR3 
               
               
                   
               
               
                 306 
                   
                 Val Ser Tyr Leu Ser Thr Ala Ser Ser Leu 
               
               
                 Adalimumab 
                   
                 Asp Xaa 
               
               
                 V H  CDR3 
                   
                 Xaa = Tyr or Asn 
               
               
                   
               
               
                 307 
                   
                 Ala Ala Ser Thr Leu Gln Ser 
               
               
                 Adalimumab 
               
               
                 V L  CDR2 
               
               
                   
               
               
                 308 
                   
                 Ala Ile Thr Trp Asn Ser Gly His Ile Asp 
               
               
                 Adalimumab 
                   
                 Tyr Ala Asp Ser Val Glu Gly 
               
               
                 V H  CDR2 
               
               
                   
               
               
                 309 
                   
                 Arg Ala Ser Gln Gly Ile Arg Asn Tyr Leu 
               
               
                 Adalimumab 
                   
                 Ala 
               
               
                 V L  CDR1 
               
               
                   
               
               
                 310 
                   
                 Asp Tyr Ala Met His 
               
               
                 Adalimumab 
               
               
                 V H  CDR1