Patent Publication Number: US-2013230884-A1

Title: Methods to Identify Synthetic and Natural RNA Elements that Enhance Protein Translation

Description:
CROSS-REFERENCE 
     This application claims priority to U.S. Provisional Patent Application Ser. No. 61/365,133 filed Jul. 16, 2010, incorporated by reference herein in its entirety. 
    
    
     STATEMENT OF U.S. GOVERNMENT INTEREST 
     This work was funded in part by NIH Eureka Award GM085530. The U.S. government has certain rights in the invention. 
    
    
     BACKGROUND 
     Ribosomal initiation constitutes a critical step in the protein translation process, allowing the ribosome to locate the correct AUG start site in the RNA message and initiate the transfer of genetic information from RNA into proteins via the genetic code. In eukaryotes, recruitment of the 40S ribosomal subunit to the RNA message occurs by recognition of a 7-methylguanosine cap located at the 5′ end of the mRNA strand. Ribosomal recruitment can also occur by a less common cap-independent mechanism, an example of which is the internal ribosomal entry site (IRES). In many cases, the recruitment site is located some distance upstream of the initiation codon, which poses the question of how the ribosome is able to bypass the intervening sequence. While linear scanning is the dominant model used to explain this process, emerging evidence suggests that transient mRNA-rRNA base pairing may play an important role in the initiation of certain mRNAs. This possibility, and the fact that the genome is routinely and pervasively transcribed into RNA, raise many interesting questions about the role of RNA inside cells and the potential for many unknown protein coding regions. 
     Discovering translation initiation elements (TIEs), also known as translation enhancing elements (TEEs) in human and other higher order genomes is a challenging problem as computational methods are unable to locate these sequences at the DNA level. This limitation has created a pressing need for new functional tools that can be used to identify and map these sequences in known genomes. 
     SUMMARY OF THE INVENTION 
     In a first aspect, the present invention provides nucleic acid libraries comprising a plurality of linear recombinant double stranded DNA constructs, wherein each double stranded DNA construct comprises 
     (a) a promoter; 
     (b) a heterologous coding region downstream from the promoter, wherein the coding region encodes a detectable polypeptide; 
     (c) a heterologous cross-linking region downstream of the coding region; 
     (d) a heterologous polynucleotide sequence of between 20-500 base pairs in length located downstream of the promoter and upstream of the coding region; and 
     (e) a first PCR primer binding site and a second PCR primer binding site, wherein the first PCR primer binding site is upstream of the polynucleotide sequence and the second PCR primer site is downstream of the polynucleotide sequence; 
     wherein at least 10 13  different polynucleotide sequences are represented in the plurality of double stranded nucleic acid constructs, and wherein the first PCR primer and the second PCR primer are the same for each construct in the plurality of double stranded nucleic acid constructs. 
     In a second aspect, the present invention provides mRNA pools, comprising mRNA transcripts resulting from transcription of the nucleic acid libraries of the first aspect of the invention. 
     In a third aspect, the present invention provides methods for identifying translational enhancing elements (TEEs), comprising 
     (a) contacting the nucleic acid library of the first aspect of the invention with reagents for RNA transcription under conditions to promote transcription of RNA from the double stranded nucleic acid constructs, resulting in an RNA expression product; 
     (b) contacting the RNA expression product with reagents for ligating a linker containing a puromycin residue to the 3′ end of the RNA expression product, resulting in a labeled RNA expression product; 
     (c) contacting the labeled RNA expression product with reagents for protein expression under conditions to promote protein translation from the labeled RNA expression product, resulting in a RNA-polypeptide fusion product; 
     (d) isolating RNA-polypeptide fusion products; 
     (e) converting the isolated RNA-polypeptide fusion products to cDNA by reverse transcription-PCR using a primer to the 3′ end of the isolated RNA-polypeptide fusion products; 
     (f) amplifying the cDNA by PCR using primers to the 5′ and 3′ end of the cDNA; and 
     (g) repeating steps (a)-(f) a desired number of times, wherein the amplified polynucleotide sequence fragments comprise TEEs. 
     In a fourth aspect, the present invention provides isolated polynucleotides, comprising a nucleic acid sequence according to any one of SEQ ID NOS: 1-5 and 7-645. These polynucleotides have been identified as TEEs using the methods of the present invention. 
     In a fifth aspect, the present invention provides expression vectors comprising 
     (a) a promoter; 
     (b) a heterologous TEE downstream of the promoter, where the TEE comprises a polynucleotide according to the fourth aspect of the invention; and 
     (c) a cloning site suitable for cloning of an protein-encoding nucleic acid of interest located upstream of the TEE, and downstream of the promoter. 
     In a sixth aspect, the present invention provides recombinant host cells comprising the expression vector of the fifth aspect of the invention. 
     In a seventh aspect, the present invention provides methods for protein expression, comprising contacting an expression vector of the fifth aspect of the invention with reagents and under conditions suitable for promoting expression of a polypeptide cloned into the cloning site. 
    
    
     
       DESCRIPTION OF THE FIGURES 
         FIG. 1 . In vitro selection and characterization of RNA elements that mediate cap-independent. (A) Human genomic DNA fragments were inserted into a DNA cassette containing all of the sequence information necessary to perform an mRNA display selection. For each selection round, the dsDNA pool was in vitro transcribed into ssRNA, conjugated to a DNA-puromycin linker, and translated in vitro. Uncapped mRNA sequences that initiate translation of an intact ORF become covalently linked to a His-6 protein affinity tag encoded in the RNA message. Functional molecules are recovered, reverse transcribed, and amplified by PCR to generate the input for the next round of selection. (B) Generation of RNA-protein fusion molecule by the natural peptidyl transferase activity of the ribosome, which catalyzes the formation of a non-hydrolyzable amide bond between puromycin and the polypeptide chain. (C) The selection progress was monitored by measuring the fraction of S 35 -labeled mRNA-peptide fusions that bound to an oligo-dT column and a Ni-NTA affinity column. Chromosomal distribution of in vitro selected sequences with 100% sequence similarity to the human reference genome (D) and their evolutionary conservation compared to the starting library (round 0) (E). (F) The distribution of individual repeat families in the starting library, random genomic sequences, and the in vitro selected sequences. 
         FIG. 2 . Functional analysis of top nine sequences in human cells. (A) Schematic diagram showing the individual steps of a coupled transcription-translation assay for cytoplasmic RNA expression and analysis. A luciferase reporter plasmid carrying an insert and a promoter sequence specific to the vaccinia virus is transfected into HeLa cells that are immediately infected with vaccinia virus. Virus-infected cells synthesize a vaccinia RNA polymerase that enables cytoplasmic transcription of the reporter plasmid into RNA. The mRNA transcripts are translated by endogenous ribosomes and the cells are assayed for bioluminescence activity after 6 hours of infection. The translation efficiency of the top nine sequences identified in the cell-based screen in (B) HeLa cells and (C) in vitro in HeLa cell lysate. 
         FIG. 3 . Functional analysis of the top nine sequences in the hairpin plasmid. (A) The sequences were inserted into a firefly reporter plasmid (F-luc-hp) containing a stable stem-loop structure. (B) The translation efficiency of the controls with no insert in vitro and in cell-based assays with and without the stable stem-loop structure. (C) The translation efficiency of the top nine sequences in vitro relative to the no insert control.
         (D) The translation efficiency of the top nine sequences in HeLa cells relative to the no insert control after normalization for mRNA (E) No infection assay in HeLa cells demonstrating that HGL6.877, HGL6.1033, and HGL6.733 have weak promoter activity that is specific to vaccinia virus infection. No activity is observed for these sequences in the absence of the vaccinia virus (inset).       
         FIG. 4 . Translation initiation efficiency of AUG triplet patterns. (A) In vitro translation efficiency of selected sequences with in-frame and out-of-frame AUG triplets. (B) Gel image illustrating start site usage of sequences in rabbit and human cell lysate. (C) In vitro translation efficiency of HGL6.877 and an unselected sequence (HGL0.53) with various combinations of AUG triplets. 
     
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     In a first aspect, the present invention provides nucleic acid libraries comprising a plurality of linear recombinant double stranded DNA constructs, wherein each double stranded DNA construct comprises 
     (a) a promoter; 
     (b) a heterologous coding region downstream from the promoter, wherein the coding region encodes a detectable polypeptide; 
     (c) a heterologous cross-linking region downstream of the coding region; 
     (d) a heterologous polynucleotide sequence of between 20-500 base pairs in length located downstream of the promoter and upstream of the coding region; and 
     (e) a first PCR primer binding site and a second PCR primer binding site, wherein the first PCR primer binding site is upstream of the polynucleotide sequence and the second PCR primer site is downstream of the polynucleotide sequence; 
     wherein at least 10 13  different polynucleotide sequences are represented in the plurality of double stranded nucleic acid constructs, and wherein the first PCR primer and the second PCR primer are the same for each construct in the plurality of double stranded nucleic acid constructs. 
     The nucleic acid libraries according to the present invention can be used, for example, in the methods of the invention for performing in vitro selection for the isolation of RNA elements (TEEs, including internal ribosome entry sites (IRESs)) that can mediate cap-independent protein translation. The libraries comprise a series of linear constructs, which, when used in in vitro selection methods as described herein, permit use of a library diversity of at least 10 13  different polynucleotide sequences. As described in detail below, the inventors have used the libraries of the present invention to identify a large number of novel TEEs, including a number of IRESs. As used herein, a “library” is a collection of linear double stranded nucleic acid constructs. 
     As used herein, “heterologous” means that none of the promoter, coding region, genomic fragment, and cross-linking region are normally associated with each other (ie: they are not part of the same gene in vivo), but are recombinantly combined in the construct. 
     As used herein, a “promoter” is any DNA sequence that can be used to help drive RNA expression of a DNA sequence downstream of the promoter. Suitable promoters include, but are not limited to, the T7 promoter, SP6 promoter, CMV promoter, and vaccinia virus synthetic-late promoter. As will be understood by those of skill in the art, a given double stranded DNA construct may contain more than one promoter, as appropriate for a given proposed use. 
     As used herein, a “coding region” is any DNA sequence encoding a polypeptide product. As used herein, a “detectable polypeptide” is any polypeptide whose expression can be detected, including but not limited to a fluorescent polypeptide (GFP, BFP, etc.), a member of a binding pair, an affinity tag, etc. The ability to detect the polypeptide greatly facilitates the methods of the invention. Non-limiting examples of such detectable polypeptides include affinity tags, protein DX (Smith et al. (2007) PLoS ONE 2, e467), maltose-binding protein (MBP), streptavadin, glutathionine S-transferase (GST), flagellar protein FlaG (FLAG affinity tag), and myelocytomatosis and viral oncogene homologs (Myc affinity tag). 
     As used herein, a “cross linking region” is any nucleic acid sequence that can be expressed as RNA, where the expressed RNA can serve as a site for ligation/binding to a linker to form a stable complex between mRNA-ribosome-protein. In a preferred embodiment, expressed RNA from the cross-linking region can serve as a site for ligation to a linker containing a 3′-puromycin residue. In a non-limiting embodiment, the expressed RNA from the cross-linking region can serve as a site for photo-ligation of a psoralen-DNA-puromycin linker (5′-psoralen-(oligonucleotide complementary to linker)-(PEG 9 ) 2 -A 15 -ACC-puromycin). In a preferred embodiment, the linker is a DNA linker, and the mRNA expressed from the cross linking region is complementary to the DNA linker sequence to be used. 
     The polynucleotide sequence can be any suitable length, such as between 20-1000 base pairs. In a preferred embodiment, the polynucleotide sequence is between 20-500 base pairs, and may comprise genomic fragments, such as a representation of an entire or partial genome from an organism of interest, or may comprise synthetic sequences. In embodiments where genomic fragments are used, the genomic fragments may be generated by any appropriate means, including restriction enzyme digestion, shearing, polynucleotide synthesis, etc. Genomic fragments from any suitable organism of interest may be used, including but not limited to human, mammal, fish, reptile, plant, yeast, insect, prokaryotic, bacterial ( E. coli , etc.), viral, fungal, and pathogenic organism genomic fragments. In another preferred embodiment, such genomic fragments are obtained from plurality of individual organisms of a single species; in a further embodiment, the plurality of individual organisms of a single species differ in ancestry, age, gender, and/or other characteristics. 
     The primer binding sites provide regions of known sequence around the polynucleotide sequence of unknown sequence to be tested for TEE activity. Additionally the primer binding sites provide a way to amplify only the polynucleotide sequence back out of the construct as desired. As will be understood by those of skill in the art, any suitable sequence can be used as a primer binding site so long as it can be used to bind a primer of interest. The primer binding site may be immediately adjacent to the polynucleotide sequence, or there may be additional nucleotides present between the primer binding site and the polynucleotide sequence as deemed appropriate for a given purpose. 
     As used herein, “at least 10 13  different polynucleotide sequences are represented in the plurality of double stranded nucleic acid constructs” means that the library, in its entirety, contains at least 10 13  different polynucleotide sequences that can be tested for TEE activity, while each different double stranded nucleic acid construct contains only a single polynucleotide sequence. In various embodiments, at least 10 14  different polynucleotide sequences or at least 10 15  different polynucleotide sequences are represented in the plurality of double stranded nucleic acid constructs. 
     It will be understood by those of skill in the art that the constructs of the invention may comprise further nucleotide elements as appropriate for a given intended use. In one preferred embodiment, the double stranded nucleic acid constructs further comprise one or more unique restriction sites upstream of the polynucleotide sequence and downstream of the promoter, and one or more unique restriction sites downstream of the polynucleotide sequence. This embodiment provides a further means by which to isolate polynucleotide sequences of interest from the constructs. In a further embodiment, the constructs do not include sequences encoding a 3′ poly(A) tail, or sequences that promote formation of a 5′ cap on the resulting transcript. 
     In another preferred embodiment, the second (3′) primer binding site is immediately upstream of the coding region in the double stranded nucleic acid construct. In this embodiment, the 3′ primer binding site abuts the coding region when the polynucleotide sequence is upstream of the promoter. 
     In a second aspect, the present invention provides an mRNA pool resulting from transcription of the library of any embodiment of the first aspect of the invention. Such mRNA pools can be used, for example, in the methods of the invention below. Any suitable technique for RNA transcription can be used. In one non-limiting embodiment, the double stranded DNA constructs each comprise a T7 RNA polymerase promoter, and the library is transcribed in vitro using T7 RNA polymerase, using standard techniques. It will be clear to those of skill in the art how to optimize transcription conditions in terms of buffers, nucleotides, salt conditions, etc., based on the general knowledge of in vitro transcription techniques in the art. The resulting mRNA pools will comprise single stranded RNA from all/almost all the double stranded DNA constructs in the library. In a further embodiment, the transcripts in the pooled mRNA comprise a DNA linker, containing a 3′ puromycin residue, ligated at the 3′ end of the transcript. In a further aspect, the invention provides pooled mRNA-peptide fusion molecules resulting from in vitro translation of the pooled mRNA. Methods for in vitro translation of RNA transcripts are well known to those of skill in the art. In one non-limiting embodiment, the methods comprise incubating the pooled mRNA with rabbit reticulocyte lysate and  35 S-methionine for a suitable time. The method may further comprise incubating the mixture overnight in the presence of suitable amounts of KCl and MgCl 2  to promote fusion formation. When the pool of RNA is translated in vitro, transcripts that contain a TEE (such as an IRES) in their 5′ UTR would initiate translation and produce an mRNA-peptide fusion molecule; thus, modifying TEE-containing RNAs with a selectable tag. The chemical bond forming step of mRNA display is due to the natural peptidyl transferase activity of the ribosome, which catalyzes the formation of a non-hydrolyzable amide bond between puromycin and the polypeptide chain ( FIG. 1B ). mRNA-peptide fusion molecules can be isolated by affinity purification, reverse-transcribed, and amplified to regenerate the pool of DNA for another selection cycle. 
     In a third aspect, the present invention provides in vitro methods for identifying translational enhancing elements (TEEs), comprising 
     (a) contacting the nucleic acid library of any embodiment or combination of embodiments of the first aspect of the invention with reagents for RNA transcription under conditions to promote transcription of RNA from the double stranded nucleic acid constructs, resulting in an RNA expression product; 
     (b) contacting the RNA expression product with reagents for ligating a linker containing a puromycin residue to the 3′ end of the RNA expression product, resulting in a labeled RNA expression product; 
     (c) contacting the labeled RNA expression product with reagents for protein expression under conditions to promote protein translation from the labeled RNA expression product, resulting in a RNA-polypeptide fusion product; 
     (d) isolating RNA-polypeptide fusion products; 
     (e) converting the isolated RNA-polypeptide fusion products to cDNA by reverse transcription-PCR using a primer to the 3′ end of the isolated RNA-polypeptide fusion products; 
     (f) amplifying the cDNA by PCR using primers to the 5′ and 3′ end of the cDNA; and 
     (g) repeating steps (a)-(f) a desired number of times, wherein the amplified polynucleotide sequence fragments comprise TEEs. 
     The methods of this aspect of the present invention serve to isolate RNA elements that could mediate cap-independent translation (ie: TEEs, including but not limited to IREs). The mechanism-based approach of mRNA display provides an efficient method to systematically and comprehensively survey nucleic acid sequences for all of the possible RNA elements that could initiate translation of uncapped mRNA transcripts. Since IRESs function by a cap-independent mechanism, this selection serves to identify IRESs as well as TEEs that promote cap-independent translation but do not initiate internally. All terms used in this third aspect have the same meaning as used elsewhere herein; similarly, all embodiments of the nucleic acid libraries and components thereof that are disclosed above, and combinations thereof, can be used in the methods of the invention. Thus, for example, each double stranded DNA construct comprises 
     (a) a promoter; 
     (b) a heterologous coding region downstream from the promoter, wherein the coding region encodes a detectable polypeptide; 
     (c) a heterologous cross-linking region downstream of the coding region; 
     (d) a heterologous polynucleotide sequence of between 20-1000 base pairs in length located downstream of the promoter and upstream of the coding region; and 
     (e) a first PCR primer binding site and a second PCR primer binding site, wherein the first PCR primer binding site is upstream of the polynucleotide sequence and the second PCR primer site is downstream of the polynucleotide sequence. In one non-limiting embodiment, the heterologous polynucleotide sequences are randomly digested fragments (in various non-limiting embodiments, ranging between 20-1000 nts, 20-750 nts, 20-500 nts; or about 150 nts) of total human DNA. Since the heterologous polynucleotide sequence is located downstream of the promoter and upstream of the coding region. 
     In the method, step (f) amplifying the cDNA by PCR using primers to the 5′ and 3′ end of the cDNA serves to add sequence information that was lost in steps (a) and (e). In one embodiment, primers to add a promoter (such as a T7 promoter) to the 5′ end and the cross-linking region (such as a photo-crosslinking) site (3′ end) back onto the DNA library are after each round of selection. The sequence of these PCR primers may vary depending on how each library is constructed. The result of this PCR is the fully constructed double stranded nucleic acid construct, which can be used to repeat steps (a)-(f) as desired. 
     Contacting the RNA expression product with reagents for ligating a linker containing a puromycin residue to the 3′ end of the RNA expression product, resulting in a labeled RNA expression product, can be carried out via any suitable method, including photo-crosslinking or Moore-Sharp splint-directed ligation. 
     Any suitable linker may be used. In a preferred embodiment the linker comprises a DNA linker complementary to the transcribed single stranded RNA. The DNA linker may comprise any suitable modifications, including but not limited non-natural residues and pegylation, as can be used in mRNA display. 
     In one preferred embodiment, the polynucleotide sequences in the library comprise genomic fragments; in a further preferred embodiment the starting pool of constructs used in the methods contains at least a 5×-1000× coverage of the genome of interest. 
     General conditions for in vitro transcription and translation, PCR, reverse transcription, and mRNA display techniques (including contacting an RNA expression product with reagents for ligating a linker containing a puromycin residue to the 3′ end of the RNA expression product), are well known to those of skill in the art. Exemplary such conditions are described above and in the examples that follow. To favor the selection of RNA elements that enhance ribosomal recruitment via a cap-independent mechanism, the pool of RNA transcripts is preferably devoid of a 5′ cap and 3′ poly(A) tail. As will be apparent to those of skill in the art, this can be accomplished, for example, by not including polyT sequences in the DNA template (to avoid poly(A) tail production) and by not providing capping enzymes required for 5′ cap production. 
     When the pool of RNA is translated in vitro, transcripts that contain a TEE in their 5′ UTR initiate translation and produce an mRNA-peptide fusion molecule; thus, modifying TEE-containing RNAs with a selectable tag. The chemical bond forming step of mRNA display is due to the natural peptidyl transferase activity of the ribosome, which catalyzes the formation of a non-hydrolyzable amide bond between puromycin and the polypeptide chain ( FIG. 1B ). mRNA-peptide fusion molecules can then be isolated by affinity purification, reverse-transcribed, and amplified to regenerate the pool of DNA for another selection cycle. 
     In one non-limiting embodiment, for each round of selection, the dsDNA library was transcribed with an RNA polymerase suitable for the promoter being used, photo-ligated to a psoralen-DNA-puromycin linker (5′-psoralen-oligonucleotide complementary to linker)-(PEG 9 ) 2 -A 15 -ACC-puromycin), and translated in vitro by incubating the library with rabbit reticulocyte lysate and  35 S-methionine under suitable conditions. mRNA-peptide fusion molecules are reverse transcribed, and can be purified by any suitable means, including but not limited to a two-step procedure on oligo (dT)-cellulose beads (NEB) and Ni-NTA agarose affinity resin (Qiagen). Functional TEEs are recovered by any suitable technique, including but not limited to eluting the column with imidazole, dialyzing the sample into water, and amplifying the cDNA by PCR. The selection progress can be monitored using any suitable technique, including but not limited to determining the fraction of S 35 -labeled mRNA-peptide fusions that remained on the oligo (dT)/Ni-NTA affinity columns. After a desired number of rounds of selection and amplification, the TEEs can be identified by any suitable means, including but not limited to cloning and sequencing of the amplified DNA constructs. 
     The selection process (steps (a)-(f)) can be carried out any suitable number of times deemed appropriate to identify TEEs, such as 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more times. In one preferred embodiment, at least three selection cycles are carried out, such that step (g) comprises repeating steps (a)-(f) at least two more times, and even more preferably at least 3, 4, 5, 6, 7, 8, 9, or more times. 
     In one embodiment, the method further comprises testing polynucleotide sequences identified as TEEs for TEE activity in vivo using, for example, the vaccinia system described herein. Any suitable system may be used. In one non-limiting embodiment, a plasmid-based reporter assay that allows coupled transcription and translation to occur in the cytoplasm of human cells was developed ( FIG. 2A ), to test sequences under conditions that are not subject to nuclear processing. This system is based on an EMCV-driven system that relies on vaccinia virus (VACV) to circumvent nuclear expression (25). TEE candidate sequences are cloned into a monocistronic firefly luciferase reporter plasmid (F-luc-mono) containing a VACV-specific promoter. Transfected HeLa cells are infected with VACV, and after a brief incubation, cells are lysed and assayed for luciferase activity. Plasmids carrying no-insert or a randomly chosen sequence from the starting pool provided a basal level of activity. 
     In a further embodiment, TEE candidate sequences are tested for the ability to initiate internal translation initiation. Any suitable assay for testing internal translation initiation can be used, including but not limited to those disclosed herein. In one non-limiting embodiment, TEE candidate sequences are inserted into a firefly reporter plasmid (F-luc-hp) containing a stable stem-loop structure (ΔG=−58 kcal/mol) to prevent ribosomal scanning ( FIG. 3A ) (26). 
     In a fourth aspect, the present invention provides isolated polynucleotides, comprising a nucleic acid sequence according to any one of SEQ ID NOS: 1-5 and 7-645. In another embodiment, the isolated polynucleotides comprise or consist of a sequence according to one or more of SEQ ID NO: 7-645, listed in Table 1. The isolated polynucleotides listed in the recited tables were all identified as TEEs by the methods of the invention; all are human genomic sequences, and thus can be used, for example, in designing expression vectors for improved translational efficiency of one or more proteins encoded by the vector. In various preferred embodiments, the isolated polynucleotides are between 13-180, 13-170, 13-160, 13-150, 13-140, 13-130, 13-120, 13-110, 13-100, 13-90, 13-80, 13-70, 13-60, 13-50, 13-40, 13-30, or 13-20 nucleotides in length. In a preferred embodiment, the isolated polynucleotides consist of the recited sequence. In a further embodiment, the isolated polynucleotides comprise the sequence of SEQ ID NO:4 (A/-)(A/G)ATC(A/G)(A/G)TAAA(T/C)G, wherein the isolated polynucleotides is between 13-200 nucleotides in length. SEQ ID NO:4 is a consensus sequence found within a number of the TEES (Clones 985 (SEQ ID NO:448), 1092 (SEQ ID NO:495), 1347 (SEQ ID NO:623), 906 (SEQ ID NO:408), 12 (SEQ ID NO:12), 1200 (SEQ ID NO:553), 958 (SEQ ID NO:434), 1011 (SEQ ID NO:458), 459 (SEQ ID NO:214) in Table 1) identified using the methods of the invention. In a preferred embodiment, the isolated polynucleotides comprise the sequence of SEQ ID NO:55′-AAATCAATAAATG-3′, which is a conserved sequence found in the top-performing TEEs as described in the examples that follow. In various preferred embodiments, the isolated polynucleotides are between 13-180, 13-170, 13-160, 13-150, 13-140, 13-130, 13-120, 13-110, 13-100, 13-90, 13-80, 13-70, 13-60, 13-50, 13-40, 13-30, or 13-20 nucleotides in length. 
     In one embodiment, the polynucleotide is selected from the group consisting of SEQ ID NO:583 (clone 1267), SEQ ID NO:397 (clone 877), SEQ ID NO:54 (clone 100), SEQ ID NO:401 (clone 884), SEQ ID NO:471 (clone 1033), SEQ ID NO:327 (clone 733), SEQ ID NO:398 (clone 878), SEQ ID NO:301 (clone 675), and SEQ ID NO:310 (clone 694). These sequences have been identified as IRESs using the methods disclosed herein. In a further embodiment, the present invention provides isolated polynucleotides comprising a nucleic acid sequence according to SEQ ID NO:1. This sequence represents a consensus sequence of a subset of 733 (SEQ ID NO:327), 877 (SEQ ID NO:397), 1033 (SEQ ID NO:471), and 1267 (SEQ ID NO:583), and thus is strongly correlated with activity. In further embodiments, the isolated polynucleotides comprise a nucleic acid sequence according to SEQ ID NO:2 or SEQ ID NO:3, which are longer portions of the consensus sequence between 733 (SEQ ID NO:327), 877 (SEQ ID NO:397), 1033 (SEQ ID NO:471), 1267 (SEQ ID NO:583. 
     
       
         
           
               
            
               
                 SEQ ID NO: 1: 
               
               
                 5′AT(C/G)GAAT(C/G)(G/A)AA(G/T)(A/G/C)GAATGGA(A/T) 
               
               
                   
               
               
                 (A/T)(C/A/G)(A/G)AA(T/A)GGAAT(G/A)GAAT(T/G)(G/A)A 
               
               
                   
               
               
                 ATGGAATGGAA(T/A)(T/G)GA(A/T)T(G/C)GAATG-3′ 
               
               
                   
               
               
                 SEQ ID NO: 2: 
               
               
                 5′-(  --)(  --)(  --)(  --)(  --) 
               
               
                   
               
               
                 (  --)(  --)(  --)(  --)(  /--)(--/  ) 
               
               
                   
               
               
                 (-  )AT(C/G) 
               
               
                   
               
               
                 GAAT(C/G)(G/A)AA(G/T)(A/G/C)GAATGGA(AT)(A/T) 
               
               
                   
               
               
                 (C/A/G)(A/G)AA(T/A)GGAAT(G/A)GAAT(T/G)(G/A) 
               
               
                   
               
               
                 AATGGAATGGAA(T/A)(T/G)GA(A/T)T(G/C)GAATG-3′ 
               
               
                   
               
               
                 SEQ ID NO; 3 
               
               
                 5′-(  --)(  --)(  --)(  --)(  --)(  --) 
               
               
                   
               
               
                 (  --)(  --)(  --)(  --)(A/--)(A/--)(G/A/--) 
               
               
                   
               
               
                 (C/T/--)(G/--)(G/--)(A/--)(A/--)(T/--)(T/C/--) 
               
               
                   
               
               
                 (--/A/G)(--/A)AT(C/G) 
               
               
                   
               
               
                 GAAT(C/G)(G/A)AA(G/T)(A/G/C)GAATGGA(AT)(A/T) 
               
               
                   
               
               
                 (C/A/G)(A/G)AA(T/A)GGAAT(G/A)GAAT(T/G)(G/A) 
               
               
                   
               
               
                 AATGGAATGGAA(T/A)(T/G)GA(A/T)T(G/C)GAATG-3′ 
               
            
           
         
       
     
     In a fifth aspect, the present invention provides expression constructs comprising: 
     (a) a promoter; 
     (b) a heterologous translational initiation element (TEE) downstream of the promoter, where the TEE comprises or consists of a sequence according to any one of SEQ ID NO:1-5 and 7-645; and 
     (c) a polylinker suitable for cloning of an open reading frame of interest located upstream or downstream of the TEE, and downstream of the promoter. 
     In this aspect, the invention provides constructs comprising the TEEs of the invention that are positioned relative to the polylinker (ie: one or more unique restriction sites to facilitate cloning) to increase translational efficiency of any polynucleotide coding region cloned into the polylinker. In a preferred embodiment, the TEE is between 13-500 nucleotides in length; in a more preferred embodiment, between 13 and 200 nucleotides in length. In a preferred embodiment, the polylinker is located downstream of the TEE. Any suitable coding region for which an increase in translational efficiency is desired can be cloned into the vector. Thus, in a further embodiment, the construct comprises a polynucleotide coding region cloned into the polylinker. In a further preferred embodiment, the TEE comprises or consists of the sequence of any one or more of SEQ ID NOS:1-5, 448, 495, 623, 408, 12, 553, 434, 458, 214, 327, 397, 471, and 583. In a further preferred embodiment, the TEE comprises or consists of the sequence of any one or more of 583 (clone 1267), SEQ ID NO:397 (clone 877), SEQ ID NO:54 (clone 100), SEQ ID NO:401 (clone 884), SEQ ID NO:471 (clone 1033), SEQ ID NO:327 (clone 733), SEQ ID NO:398 (clone 878), SEQ ID NO:301 (clone 675), and SEQ ID NO:310 (clone 694). These sequences have been identified as IRESs using the methods disclosed herein. Suitable promoters include, but are not limited to, the T7 promoter, SP6 promoter, CMV promoter, and vaccinia virus synthetic-late promoter. The constructs in this aspect of the invention may be linear constructs, or may be part of an expression vector, such as a plasmid or viral-based expression vector as are known in the art. As will be apparent to those of skill in the art, the constructs may contain any other components as desired by a user, such as origins of replication, selection markers, etc. 
     In a sixth aspect, the present invention provides recombinant host cell comprising an expression vector of any embodiment or combination of embodiments of the fifth aspect of the invention. Such host cells can be used, for example, to prepare large amounts of the expression vector and to provide for expression of the encoded proteins in the host cells. Any suitable host cell may be used, including but not limited to bacterial and eukaryotic host cells, including but not limited to mammalian and human cells. 
     In a seventh aspect, the present invention provides methods for protein expression, comprising contacting an expression construct according to any embodiment or combination of embodiments of the fifth aspect of the invention, wherein the construct comprises a polynucleotide coding region cloned into the polylinker, with reagents and under conditions suitable for promoting expression of the polypeptide encoded by the polynucleotide coding region. It is within the level of skill in the art to choose appropriate reagents and conditions for RNA expression from the expression construct, followed by translation of the encoded polypeptide. Exemplary reagents and conditions are described in the examples that follow. The methods of this aspect of the invention may be carried out in vitro or in vivo. 
     Unless clearly dictated otherwise by the context, all embodiments of any aspect of the invention may be combined with other embodiments of the same and different aspects. 
     Example 1 
     Genome-Wide Identification of Human Cap-Independent Translation Initiation Elements 
     Internal ribosomal entry sites (IRESs) are RNA elements located in the untranslated region of mRNA transcripts that initiate protein synthesis independent of the canonical 5′ cap. To date, only a handful of IRESs have been identified in higher order genomes. Here, we have applied a mechanism-based approach to search the entire human genome for RNA sequences with IRES activity. Starting from a library of &gt;10 13  human RNA fragments, we performed iterative cycles of mRNA display to capture leader sequences that mediate cap-independent translation. The selected sequences are distributed throughout the genome, and often occur in repetitive regions with high conservation to mammals. We observed strong cis-regulatory activity for more than 200 sequences tested in a monocistronic translation-enhancing assay. The most active sequences function as potent IRESs in vitro and in human cells. These results demonstrate the power of mRNA display as a genome-wide tool for identifying functional IRESs. 
     Initiation is a critical step in protein translation, allowing the ribosome to locate the translation start site in the RNA message and initiate the transfer of genetic information from RNA into protein via the genetic code. In eukaryotes, the 43S ribosomal pre-initiation complex (PIC) is recruited to the RNA message by recognition of the eIF4F cap-binding complex bound to a 7-methylguanosine cap located at the 5′ end of the mRNA strand (1, 2). A subset of leader sequences known as internal ribosomal entry sites (IRESs) can bypass the 5′ cap structure by recruiting the ribosome to internal positions in the 5′ untranslated region (5′ UTR) (3-7). IRESs play an important role in gene regulation by allowing essential proteins to be synthesized when normal cap-dependent translation is compromised (8). This can occur during regular cellular processes like mitosis and apoptosis (9, 10), as well as during hypoxia (11), viral infection (12), or during states of cellular dysregulation (13). 
     Ribosomal profiling, a technique that combines polysome fractioning with DNA microarrays, has been employed to profile cellular translation under conditions that impede normal cap-dependent translation (14). Data from these studies suggest that the human genome likely contains many more IRESs than previously thought; however, only a few human IRESs have been characterized in detail. These studies further suggest that cellular systems may possess mechanisms to support the coordinated regulation of specific IRES subtypes, as different physiological conditions gave rise to different IRES subsets. Despite a wealth of useful information gained by ribosomal profiling, this approach suffers from limited resolution and sequence accuracy, as well as an inability to distinguish stalled ribosomes from actively translating ribosomes. While continued technological advancement could circumvent some of these problems, thorough investigation of the human genome would require exhaustive sampling of countless conditions and cell types. This limitation has created a need for new molecular tools that can be used to identify human IRESs on a genome-wide scale (15). 
     To identify IRESs encoded in the human genome, we devised an in vitro selection strategy for the isolation of RNA elements that could mediate cap-independent translation. We reasoned that the mechanism-based approach of mRNA display provided an efficient method to systematically and comprehensively survey the entire human genome for all of the possible RNA elements that could initiate translation of uncapped mRNA transcripts (16). Since IRESs function by a cap-independent mechanism, it was hypothesized that this selection would lead to the discovery of human IRESs as well as human translation enhancing elements that promote cap-independent translation but do not initiate internally. In this scheme ( FIG. 1A ), a genomic library composed of randomly digested fragments (˜150 nts) of total human DNA was inserted into the 5′ UTR of a DNA cassette containing an open reading frame (ORF) encoding a peptide affinity tag. The library also contained all of the genetic information required for mRNA display. The library was converted to single-stranded RNA by in vitro transcription and photo-ligated at the 3′ end to a DNA linker containing a 3′ puromycin residue. To favor the selection of RNA elements that enhance ribosomal recruitment via a cap-independent mechanism, the pool of RNA transcripts was deprived of a 5′ cap and 3′ poly(A) tail. When the pool of RNA is translated in vitro, transcripts that contain an IRES in their 5′ UTR would initiate translation and produce an mRNA-peptide fusion molecule; thus, modifying IRES-containing RNAs with a selectable tag. The chemical bond forming step of mRNA display is due to the natural peptidyl transferase activity of the ribosome, which catalyzes the formation of a non-hydrolyzable amide bond between puromycin and the polypeptide chain ( FIG. 1B ) (17). mRNA-peptide fusion molecules could then be isolated by affinity purification, reverse-transcribed, and amplified to regenerate the pool of DNA for another selection cycle. 
     We started the selection with an RNA-DNA-puromycin library that contained &gt;10 13  sequences, which provided 100-1000-fold coverage of the human genome. We translated the library for 1 hour at 30° C. in nuclease treated reticulocyte lysate and fusion formation was promoted by incubating the mixture overnight at −20° C. in the presence of 600 mM KCl and 75 mM MgCl 2 . mRNA-peptide fusions were isolated from the crude lysate by affinity purification on an oligo-(dT) resin, and the elution fractions were applied to Ni-NTA agarose beads. The Ni-NTA beads were thoroughly washed to remove RNA sequences that did not form mRNA-peptide fusions or did not initiate in the correct reading frame. mRNA-peptide fusions that remained bound to the column were selectively eluted with imidazole, exchanged into buffer, reverse-transcribed, and amplified by PCR to reinitiate the selection cycle described above. We monitored the selection progress by following the proportion of S 35 -labeled mRNA-peptide fusions that remained in the pool after purification. The abundance of mRNA-peptide fusions increased up to round 5 and plateaued in round 6, indicating that the library became dominated by RNA elements that could enhance cap-independent translation ( FIG. 1C ). 
     We cloned and sequenced 712 members from round 6. Of these, 639 were non-redundant, indicating that the library contained significant sequence diversity even after six rounds of mRNA display (Table S1). Each non-redundant sequence was aligned to the human reference genome (hg18) using the UCSC BLAT web-tool (18). A subset of 229 sequences showed 100% identity to 1814 genomic locations. These sites are distributed across all 24 human chromosomes with ˜34% occurring in the intronic regions of known genes ( FIG. 1D ). The remaining 410 sequences have high homology (85-99% identity) to genomic sites, but contain small degrees of sequence variation that include single nucleotide polymorphisms in addition to small and large insertions and deletions. This level of variation is expected for individuals in a population (19), and it is known that gene regulatory sequences can differ between individual genomes (20). Since we could not distinguish between mutations that arose during the selection and those that occur naturally, we focused the remainder of our study on the set of 229 perfectly matched sequences. 
     We examined their evolutionary conservation using the 44-species UCSC alignments ( FIG. 1E ) (18). Of the 229 sequences, 82.5% are conserved in the chimpanzee genome ( Pan troglodytes ) and 43.2% are conserved in the genomes of other placental mammals (i.e., dogs, horses, and mice). The degree of sequence similarity ranged from 97-100% for chimpanzee and 96-100% for placental mammals. Sometimes significant sequence similarities (E-value&lt;9e-13) were also observed in lower vertebrate genomes. For example, HGL6.634 homologs are found in lizards ( Anolis carolinensis ) and fish ( Xenopus tropicalis  and  Gasterosteus aculeatus ). This sequence overlaps the intron-exon junction for a chromatin modification-related protein. Similarly, HGL6.1305 shows high sequence similarity to the platypus and opossum genomes. This sequence is located in the intron of a neuronal PAS domain protein—a transcription factor expressed primarily in mammalian forebrains. 
     Because many of the perfectly matched sequences mapped to multiple genomic locations, we compared the distribution of repetitive elements found in the starting library to that of all round 6 sequences. The distribution of repetitive elements in the starting library is similar to the distribution obtained by random computational sampling ( FIG. 1F ). This is expected because our starting library contained an unbiased representation of the human genome (21-23). In contrast, round 6 was enriched in sequences that align to repetitive regions of the human genome. Of the 639 non-redundant sequences, most align to regions of LINE-1 (L1) retrotransposons and satellite DNA (25% and 45%, respectively). This distribution is comparable to what we observed for the set of 229 perfectly matched sequences with the difference that L1 elements are overrepresented at the expense of satellite DNA. This difference is not unexpected, as satellite DNA is known to contain large numbers of point mutations, which preclude their ability to map with 100% identity to the human reference genome (23). 
     We chose the set of 229 perfectly matched sequences and a set of 15 high homology sequences for functional characterization in human cells. Testing large numbers of sequences in cells presents a challenging problem as traditional assays are often complicated by splicing events that can occur during nuclear transcription and export (24). To test sequences under conditions that are not subject to nuclear processing, we developed a plasmid-based reporter assay that allows coupled transcription and translation to occur in the cytoplasm of human cells ( FIG. 2A ). We were inspired by an EMCV-driven system that relies on vaccinia virus (VACV) to circumvent nuclear expression (25). We inserted the sequences into a monocistronic firefly luciferase reporter plasmid (F-luc-mono) containing a VACV-specific promoter. Transfected HeLa cells were infected with VACV, and after a brief incubation, cells were lysed and assayed for luciferase activity. Plasmids carrying no-insert or a randomly chosen sequence from the starting pool provided a basal level of activity. We confirmed with no infection controls that luciferase activity was due to cytoplasmic expression by showing that uninfected cells have luciferase values equivalent to untreated cells. Plasmids carrying the selected sequences provided a range of activity (Fig. S1); the most active sequences enhanced translation ˜100-fold relative to the basal level after normalization for RNA ( FIG. 2B ). Analysis of the isolated RNA after six hours of expression demonstrated that the transcripts were intact and full-length. The top 9 sequences were validated in vitro in HeLa cell lysate to control for the strong capping mechanism associated with VACVs. The cell-free assay recapitulated the cell-based assay, confirming that activity did not depend on a 5′ cap or VACV infection ( FIG. 2C ). 
     To test whether the selected sequences were capable of internal translation initiation, we inserted the top 9 sequences from the monocistronic assay into a firefly reporter plasmid (F-luc-hp) containing a stable stem-loop structure (ΔG=−58 kcal/mol) to prevent ribosomal scanning ( FIG. 3A ) (26). Hairpin transcripts with no insert are poorly translated in vitro and in cells, yielding 0.3% and 1.5% of the respective activity observed for unobstructed transcripts after normalization for RNA ( FIG. 3B ). We confirmed that the RNA was stable in cells and in cell lysate, indicating that differences in activity were not due to selective degradation. We examined the top 9 sequences for IRES activity by first testing the reporter constructs in HeLa cell lysate. All nine sequences promote cap-independent translation initiation at levels consistent with known cellular IRESs ( FIG. 3C ) (26). We then examined the sequences in HeLa cells using cytoplasmic expression to avoid any possibility of nuclear splicing. In agreement with the in vitro assay, all of the sequences exhibit potent IRES activity (˜100-600-fold) when compared to the no insert control after normalization for RNA ( FIG. 3D ). To test for possible cryptic promoter activity, we repeated the cytoplasmic expression assay using a knock-out plasmid (F-luc-hp-ko) that deleted the VACV promoter. Under these conditions, HGL6.884 and HGL6.733 retain activity in VACV infected cells, indicating that a portion of their activity was due to monocistronic RNA that arose from a cryptic VACV promoter site. This prediction was confirmed by assaying HGL6.884 and HGL6.733 in uninfected cells, which yielded luciferase values equivalent to untreated cells ( FIG. 3E ). Direct transfection of the RNA-hairpin constructs into the cytoplasm of HeLa cells further corroborated our finding that all nine in vitro selected sequences mediate internal translation initiation ( FIG. 3F ). 
     Many well-characterized IRESs contain AUG triplets in their 5′ UTR that are expected to impede ribosomal scanning (2). Likewise, the human in vitro selected sequences identified in round 6 also have an abundance of AUG triplets. How is it then that a given AUG codon is selected as a start site when multiple options are present? One might expect a priori that AUGs in good sequence context would lead to more efficient translation initiation; however, only 1 out of 657 AUG codons observed in the 229 sequences contains a Kozak motif (Fig. S2) (27). To investigate this question, we selected ten sequences with a range of monocistronic activity and AUG triplet patterns, and examined their relative translation initiation efficiency and start site usage in vitro. This analysis revealed a number of striking observations ( FIG. 4 , A and B, and table S2). First, sequences with similar thermodynamic stability and no AUG codons can initiate translation with different levels of efficiency (HGL6.738 vs. HGL6.140). Second, out-of-frame start sites can be just as effective at translation initiation as in-frame start sites (HGL6.928 vs. HGL6.338). Third, AUG triplets near the 5′ end of the sequence are often bypassed in favor of downstream AUGs (e.g., HGL6.512, HGL6. 962, and HGL6.1155). Last, ribosomes that initiate translation at out-of-frame AUG codons can shift back into frame before reaching the designated ORF (e.g., HGL6.338, and HGL6.1155). Taken together, this data suggests that human cap-independent translation involves cis-regulatory elements in the 5′ UTR that function as ribosomal recruitment sites. This prediction is supported by the observation that many cellular IRESs have noncontiguous segments that retain IRES activity on their own (5, 28, 29). 
     To determine what role, if any, upstream AUG codons could play in ribosomal recruitment, we removed the in-frame, out-of-frame, and all AUG triplets from a high activity sequence (HGL6.877). Mutation of the AUG triplets had a strong negative impact on the translation initiation efficiency of all HGL6.877 variants ( FIG. 4C ). Even HGL6.877Δall devoid of all AUGs was less efficient than the parent sequence, indicating that AUGs can have a profound functional role in ribosomal recruitment. To determine whether translation initiation was due to the AUG codons or the surrounding sequence, we inserted the AUGs from HGL6.877 into an unselected sequence (HGL0.53) at the same locations that they appear in HGL6.877. Both HGL6.877 and HGL0.53 are identical in length, but HGL0.53 did not otherwise contain any AUG codons. HGL0.53 nor any of its AUG variants were capable of efficient translation initiation. This result demonstrates, at least for HG6.877, that presence of AUG triplets alone is not sufficient to initiate translation, but instead requires the ribosomal recruitment site in which the AUGs are imbedded for function. 
     Our results represent the first example of mRNA display as a genome-wide tool for identifying cap-independent translation initiation elements in the human genome. The in vitro selected IRESs characterized here represent novel regulatory elements that were previously hidden in the human genome. The general scheme used to identify these sequences is readily adaptable to other organisms and translation initiation mechanisms, and the versatility of the in vitro protocol makes it possible to explore ribosomal translation under a variety of conditions. We suggest that further discovery of additional cis-regulatory elements will advance our understanding of genome structure and function, and the biological role that IRESs play in the human genome. 
     Materials and Methods 
     Library Assembly and mRNA Display Selection 
     The human DNA library was provided by the Szostak laboratory 18 . This library was modified by PCR to add the genetic information necessary for performing mRNA display 31 . For each round of selection, the dsDNA library was transcribed with T7 RNA polymerase, photo-ligated to a psoralen-DNA-puromycin linker (5′-psoralen-TAGCCGGTG-(PEG 9 ) 2 -A 15 -ACC-puromycin) (SEQ ID NO:6), and translated in vitro by incubating the library (1 nmol) with rabbit reticulocyte lysate and  35 S-methionine for 1 hour at 30° C. Fusion formation was promoted by incubating the mixture overnight at −20° C. in the presence of KCl (600 mM) and MgCl 2  (75 mM). The mRNA-peptide fusion molecules were reverse transcribed, and purified by a two-step procedure on oligo (dT)-cellulose beads (NEB) and Ni-NTA agarose affinity resin (Qiagen). Functional TEEs were recovered by eluting the column with imidazole, dialyzing the sample into water, and amplifying the cDNA by PCR. The selection progress was monitored by determining the fraction of S 35 -labeled mRNA-peptide fusions that remained on the oligo (dT) Ni-NTA affinity columns. After 6 rounds of selection and amplification, the dsDNA library was cloned and sequenced. 
     Luciferase Reporter Assay 
     A monocistronic luciferase reporter vector (pT7_v_&lt;TEE&gt;_FLuc) that contains both a T7 and a vaccinia virus synthetic late promoter was constructed by modifying a pT3-R-luc&lt;IRES&gt;F-luc(pA) 62  luciferase reporter plasmid provided by the Doudna laboratory (Gilbert et al., 2007) ,32 . HeLa and HEK-293 cells were seeded at a density of 15,000 cells per well in white 96-well plates 18 hours prior to transfection. Cells were transfected with a complex of the reporter plasmid (200 ng) and Lipofectamine 2000 (0.5 μl) in Opti-MEM (Invitrogen), and immediately infected with the Copenhagen strain (VC-2) of WT vaccinia virus at a multiplicity of infection (m.o.i) of 5 PFU/cell ( FIG. 4 ). Cells were lysed (6.5 hours post-infection) in the 96-well plates and the luciferase activity was measured using the Promega Luciferase Assay System with a Glomax microplate luminometer (Promega). Cell-free characterization of the top TEEs was performed using the Human In Vitro Protein Expression Kit (Pierce). Luciferase expression was achieved following manufacturer&#39;s protocols using 300 ng of linear template for a two-hour transcription at 32° C. followed by a 90 min translation at 30° C. 
     RNA Characterization 
     A portion of the cells used in the transfect-infect study was separately lysed to evaluate the quality of the cellular RNA. Isolated RNA was reverse transcribed with Superscript II (Invitrogen), and realtime PCR was used to determine the mRNA levels of luciferase relative to the housekeeping gene hypoxanthine-guanine phospho-ribosyltransferase (HPRT). Using the ΔΔCt method, the amount of luciferase mRNA was normalized to HPRT mRNA levels. In addition, the length of luciferase mRNA was determined using PCR to analyze the relative proportion of the 5′- and 3′-ends of representative cDNA molecules. 
     Mutagenesis Study. 
     The 13-nucleotide core motif was assayed for activity by constructing five luciferase reporter constructs in which the 13-mer motif was either added to the 5′ end of a low activity TEE (clones 499, 646 and 347) or deleted from the 5′ end of a high activity TEE (clones 1092 and 1347). HGL sequences 1092 and 1347 were regenerated with the 13-nucleotide deletion by Klenow DNA polymerase extension followed by a restriction enzyme digest with BamHI and NcoI. The digested fragments were then ligated into the luciferase reporter plasmid pT7_v_&lt;TEE&gt;_FLuc. The insertion constructs were generated by overlap PCR, and then digested and ligated into the reporter plasmid. Translation enhancement of the modified sequences was assessed using the transfect/infect assay in HeLa cells. Sequences 1347 and 499 were additionally characterized in BSC40, RK13, BHK and 129SV cells. 
     Bioinformatics Analysis 
     Bioinformatics analysis was used to analyze 143 sequences from the naïve library, and 709 sequences isolated after six rounds of in vitro selection. The genomic locations of all non-redundant sequences were determined using the BLAT webtool to map each sequence to the human reference genome (hg18) 21 . This analysis revealed that 75 sequences from the naïve pool and 227 sequences from the round 6 pool matched with perfect sequence identity to the human reference genome. The program RepeatMasker was used to classify the selected sequences into specific repeat families 33 . By randomly selecting 10,000 genomic locations, we generated the null expectation for the fraction of sequence motifs of length 200 nucleotides to overlap a repeat family. This number was 45.7% and was not statistically-significantly different from that observed for Round-0 sequences. However, the null hypothesis for TEEs is rejected at P&lt;10-6 indicating that TEEs are significantly enriched in their involvement with repeat families. 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 Clones sequenced for characterization after six rounds of mRNA display selection. 
               
            
           
           
               
               
               
               
            
               
                 Entry 
                 Clone 
                 Duplicates 
                 Sequence 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 1 
                 HGL6.1 
                 HGL6.346, 
                 AATCGAATGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATCG 
               
               
                   
                   
                 HGL6.670, 
                 AAGAGAATCATCGAATGGACC (SEQ ID NO: 7) 
               
               
                   
                   
                 HGL6.676, 
                   
               
               
                   
                   
                 HGL6.715, 
                   
               
               
                   
                   
                 HGL6.961, 
                   
               
               
                   
                   
                 HGL6.1106, 
                   
               
               
                   
                   
                 HGL6.1182, 
                   
               
               
                   
                   
                 HGL6.1338 
                   
               
               
                   
               
               
                 2 
                 HGL6.5 
                   
                 TGGAATCGAATGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGA 
               
               
                   
                   
                   
                 ATCGAAGAGAATCATCGAATGGACC (SEQ ID NO: 8) 
               
               
                   
               
               
                 3 
                 HGL6.7 
                   
                 AGCATTCATATCTTGCAGTGTTGGGAAAGAGTGAGAGGTTGTGATGTCAAGAAG 
               
               
                   
                   
                   
                 GATAGGTCAGAAGTGGAAGGTATGGGGGATTGTGCCTGCTGTCATGGCT (SEQ ID 
               
               
                   
                   
                   
                 NO: 9) 
               
               
                   
               
               
                 4 
                 HGL6.8 
                   
                 GGAACGAAATCGAATGGAACGGAATAGAATAGACTCGAATGTAATGGATTGCTA 
               
               
                   
                   
                   
                 TGTAATTGATTCGAATGGAATGGAATCGAATGGAATGCAATCCAATGGAATGGA 
               
               
                   
                   
                   
                 ATGCAATGCAATGAATGGAATGGAATGGAATGGAATGGAA (SEQ ID NO: 10) 
               
               
                   
               
               
                 5 
                 HGL6.9 
                   
                 GGAACGAAATCGAATGGAACGGAATAGAATAGACTCGAATGTAATGGATTGCTA 
               
               
                   
                   
                   
                 TGTAATTGATTCGAATGGAATGGAATCGAATGGAATGCAATCCAATGGAATGGA 
               
               
                   
                   
                   
                 ATGCAATGCAATGAATGGAATGGAATGGAATGGAATGGA (SEQ ID NO: 11) 
               
               
                   
               
               
                 6 
                 HGL6.12 
                   
                 TACGCAAATCGATAAATGTAATCCAGCATATAAACAGAACCAAAGACAAAAACC 
               
               
                   
                   
                   
                 ACATGATTATCTCAATAGATGCAGAAAAGGCC (SEQ ID NO: 12) 
               
               
                   
               
               
                 7 
                 HGL6.14 
                   
                 ACTCGAATGCAATCAACATCAAACGGAATCAAACGGAATTATCGAATGGAATCG 
               
               
                   
                   
                   
                 AAGAGAATCATCGAACGGACTCGAATGGAATCATCTAATGGAATGGAATGG 
               
               
                   
                   
                   
                 (SEQ ID NO: 13) 
               
               
                   
               
               
                 8 
                 HGL6.18 
                   
                 GAAATTCCAATTAAAATGAAATCGACTTATCTTAACAAATATAGCAATGCTGACA 
               
               
                   
                   
                   
                 ACACTTCTCCGGATATGGGTACTGCT (SEQ ID NO: 14) 
               
               
                   
               
               
                 9 
                 HGL6.20 
                   
                 AAGGAAAAGTAAAAGGAACTTAACACCTTCAAGAAAAGACAGACAAATAACAA 
               
               
                   
                   
                   
                 AACAGCAGTTTGATAGAATGAGATATCAGGGGATGGCA (SEQ ID NO: 15) 
               
               
                   
               
               
                 10 
                 HGL6.21 
                   
                 ATCAACATCAAACGGAAAAAACGGAATTATCGAATGGAATCGAAGAGAATCATC 
               
               
                   
                   
                   
                 GAACGGACC (SEQ ID NO: 16) 
               
               
                   
               
               
                 11 
                 HGL6.22 
                   
                 AAAGAAAGACAGAGAACAAACGTAATTCAAGATGACTGATTACATATCCAAGAA 
               
               
                   
                   
                   
                 CATTAGATGGTCAAAGACTTTAAGAAGGAATACATTCAAAGGCAAAAAGTCACT 
               
               
                   
                   
                   
                 TACTGATTTTGGTGGAGTTTGCCACATGGAC (SEQ ID NO: 17) 
               
               
                   
               
               
                 12 
                 HGL6.23 
                   
                 AAGGGAATTGAATAGAATGAATCCGAATGGAATGGAATGGAATGGAATGGAAT 
               
               
                   
                   
                   
                 GGAATGGAATGGAATGGAATGGAATG (SEQ ID NO: 18) 
               
               
                   
               
               
                 13 
                 HGL6.24 
                   
                 GAATGGAATCGAATCAAATTAAATCAAATGGAATGCAATAGAAGGGAATACAAT 
               
               
                   
                   
                   
                 GGAATAGAATGGAATGGAATGGAATGGACT (SEQ ID NO: 19) 
               
               
                   
               
               
                 14 
                 HGL6.25 
                   
                 ACAGCAAGAGAGAAATAAAACGACAAGAAAACTACAAAATGCCTATCAATAGT 
               
               
                   
                   
                   
                 TACTTTAAATATCAGTGGACCAAATCAGTGAAACAAAAGACACAGAGTGGC 
               
               
                   
                   
                   
                 (SEQ ID NO: 20) 
               
               
                   
               
               
                 15 
                 HGL6.27 
                   
                 TAGCAGGAAACAGCAAACTCAAATTAAGTAATTTCAAGAGCGTATCATCAATGA 
               
               
                   
                   
                   
                 ACTATTTTCAAAGATGTGGGCAAGAT (SEQ ID NO: 21) 
               
               
                   
               
               
                 16 
                 HGL6.28 
                   
                 AAACGGAATTATCAAATGGAATCGAAGAGAATCATCGAACGGACTCGAATGGAA 
               
               
                   
                   
                   
                 TCATCTAATGGAATGGAATGGAAG (SEQ ID NO: 22) 
               
               
                   
               
               
                 17 
                 HGL6.30 
                   
                 GAATGAAATGAAATCAAATNGAATGTACATGAATGGAATAGAAAAGAATGCATC 
               
               
                   
                   
                   
                 TTTCTCGAACGGAAGTGCATTGAATGGAAAGGAATCTACTGGAATGGATTCGAA 
               
               
                   
                   
                   
                 TGGAATGGAANGGGATGGAATGGTATGG (SEQ ID NO: 23) 
               
               
                   
               
               
                 18 
                 HGL6.32 
                   
                 AATGGACTCGAATGAAATCATCATCAAACGGAATCGAATGGAATCATTGAATGG 
               
               
                   
                   
                   
                 AAAGGATGGGATCATCATGGAATGGAAACGAATGGAATCACTG (SEQ ID NO: 24) 
               
               
                   
               
               
                 19 
                 HGL6.34 
                   
                 AATGGAATCATTGAATGGAATGGAATGGAATCATCAAAGAAAGGAATCGAAGG 
               
               
                   
                   
                   
                 GAATCATCGAATGGAATCAAACGGAATCATCGAATGGAATGGAATGGAATG 
               
               
                   
                   
                   
                 (SEQ ID NO: 25) 
               
               
                   
               
               
                 20 
                 HGL6.38 
                 HGL6.537 
                 AGCAGAAGAAATAACTGAAATCAGAGTGAAACTGAATCAAATTGAGATGCAAA 
               
               
                   
                   
                   
                 AATACATACGAAATGGCCAG (SEQ ID NO: 26) 
               
               
                   
               
               
                 21 
                 HGL6.40 
                   
                 AGTTAATCCGAATAGAATGGAATGGAATGCAATGGAACGGAATGGAACGGAAT 
               
               
                   
                   
                   
                 GGAATGGAATGGAATGGAATGGAATG (SEQ ID NO: 27) 
               
               
                   
               
               
                 22 
                 HGL6.42 
                   
                 ATGGAATCAACATCAAACGGAATCAAACGGAATTATCGAATGGAATCGAAGAGA 
               
               
                   
                   
                   
                 ATCATCGAACGGATTCGAATGGAATCATCTAATGGAATGGAATGGAAGAATCCA 
               
               
                   
                   
                   
                 TGGACTCGAATGCAATCATCAGCGAATGGAATCGAATGGAATCATCGAATGGAC 
               
               
                   
                   
                   
                 TCG (SEQ ID NO: 28) 
               
               
                   
               
               
                 23 
                 HGL6.44 
                   
                 AAAGGAATGGACTGGAACAAAATGAAATCGAACGGTAGGAATCGTACAGAACG 
               
               
                   
                   
                   
                 GACAGAAATGGAACGGCATGGAATGCACTCG (SEQ ID NO: 29) 
               
               
                   
               
               
                 24 
                 HGL6.47 
                   
                 AAATCAACAACAAACGGAAAAAAAAGGAATTATCGAATGGAATCAAAGAGAAT 
               
               
                   
                   
                   
                 CATCGAATGGACC (SEQ ID NO: 30) 
               
               
                   
               
               
                 25 
                 HGL6.50 
                   
                 AAATGAACAAAACTAGAGGAATGACATTACCTGACTTCAAATTATACTACAGAG 
               
               
                   
                   
                   
                 CTATAGTAACCAAAACAGCATGGTACAGGCAT (SEQ ID NO: 31) 
               
               
                   
               
               
                 26 
                 HGL6.51 
                   
                 GTAATGGAATGGAATGGAAAGGAATCGAAACGAAAGGAATGGAGACAGATGGA 
               
               
                   
                   
                   
                 ATGGAATGGAACAGAG (SEQ ID NO: 32) 
               
               
                   
               
               
                 27 
                 HGL6.52 
                 HGL6.496, 
                 ATCGAATGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATCGA 
               
               
                   
                   
                 HGL6.881, 
                 AGAGAATCATCGAATGGACC (SEQ ID NO: 33) 
               
               
                   
                   
                 HGL6.1207 
                   
               
               
                   
               
               
                 28 
                 HGL6.57 
                   
                 CAATCAGAGCGGACACAAACAAATTGCATGGGAAGAATCAATATCGTGAAAATG 
               
               
                   
                   
                   
                 GCC (SEQ ID NO: 34) 
               
               
                   
               
               
                 29 
                 HGL6.59 
                   
                 AGACCTTTCTCAGAAGACACACAAATTGCCAACAGGTATATGAAAAAATGTTCA 
               
               
                   
                   
                   
                 ATATCACTAATCATCAGGGCGATGCC (SEQ ID NO: 35) 
               
               
                   
               
               
                 30 
                 HGL6.61 
                   
                 CATGGAATCGAATGGAATTATCATCGAATGGAATCGAATGGTACCAACACCAAA 
               
               
                   
                   
                   
                 CGGAAAAAAACGGAATTATCGAATGGAATCGAAGAGAATCTTCGAACGGACC 
               
               
                   
                   
                   
                 (SEQ ID NO: 36) 
               
               
                   
               
               
                 31 
                 HGL6.63 
                   
                 GAACGATTTATCACTGAAAATTAATACTCATGCAAGTAGTAAACGAATGTAATG 
               
               
                   
                   
                   
                 ACCATGATAAGGAGACGGACGGTGGTGATAGT (SEQ ID NO: 37) 
               
               
                   
               
               
                 32 
                 HGL6.65 
                   
                 AAAGATCAANGNNCAAAAATCAGCAGCATTTCTATAAACCAACAATGTCCAGGC 
               
               
                   
                   
                   
                 TGAGAGNGAAATCAAGAAANCAATTC (SEQ ID NO: 38) 
               
               
                   
               
               
                 33 
                 HGL6.66 
                   
                 ACACACATACCAACAGAACATGACAAAAGAACAAAACCAGCCGCATGCATACTC 
               
               
                   
                   
                   
                 GATGGAGACAAAGGTAACACTGCAGAATGGTGAAGGAAGAACAGTCATTTTAAT 
               
               
                   
                   
                   
                 GACAGTGTTGGCT (SEQ ID NO: 39) 
               
               
                   
               
               
                 34 
                 HGL6.67 
                 HGL6.463, 
                 AATGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATCGAAGA 
               
               
                   
                   
                 HGL6.775, 
                 GAATCATCGAATGGACC (SEQ ID NO: 40) 
               
               
                   
                   
                 HGL6.936 
                   
               
               
                   
               
               
                 35 
                 HGL6.68 
                   
                 ATCAAAAGGAACGGAATGGAATGGAATGGAATGGAATGGAATGGAATGGAATG 
               
               
                   
                   
                   
                 GAATGAAATCAACCCGAATGGAATGGATTGGCATAGAGTGGAATGG (SEQ ID 
               
               
                   
                   
                   
                 NO: 41) 
               
               
                   
               
               
                 36 
                 HGL6.70 
                 HGL6.71 
                 TAAAGAAAAACAAACAAACAGAAATCAATGAAAATCCCATTCAAAGGTCAGCA 
               
               
                   
                   
                   
                 ACCTCAAAGACTGAAGGTAGATAAGCCCACAAGGATG (SEQ ID NO: 42) 
               
               
                   
               
               
                 37 
                 HGL6.73 
                   
                 AAACGGAAAAAAACGGAATTATCGAATGGAATCGAATAGAATCATCGAATGGA 
               
               
                   
                   
                   
                 CC (SEQ ID NO: 43) 
               
               
                   
               
               
                 38 
                 HGL6.74 
                   
                 GGAATCAACTCGATTGCAATGGAATGCAATGGAAAGGAATGGAATGCAATTAAA 
               
               
                   
                   
                   
                 GCGAATAGAATGGAATGGAATGGAATGGAACGGAATGGAATG (SEQ ID NO: 44) 
               
               
                   
               
               
                 39 
                 HGL6.76 
                   
                 GAAGAAGAAAAAACATGGATATACAATGTCAACAGAAATCAAGGAGAAACGGA 
               
               
                   
                   
                   
                 ATTTCACCAATCAATTTAGTGATCTGGGTT (SEQ ID NO: 45) 
               
               
                   
               
               
                 40 
                 HGL6.82 
                   
                 TGGAATCATCTAATGGAATGGAATGGAATAATCCATGGACTCGAATGCAATCAT 
               
               
                   
                   
                   
                 CATAAAATGGAATCGAATGGAATCAACATCAAATGGAATCAAATGGGATCATTG 
               
               
                   
                   
                   
                 AACGGAATTGAATGGAATCGTCAT (SEQ ID NO: 46) 
               
               
                   
               
               
                 41 
                 HGL6.83 
                   
                 TGAACAGAGAATTGGACAAAACGCACAAAGTAAAGAAAAAGAATGAAGCAACA 
               
               
                   
                   
                   
                 AAAGCAGAGATTTATTGAAAACAAAAGTACACACCACACAGGGTGGGAGTGG 
               
               
                   
                   
                   
                 (SEQ ID NO: 47) 
               
               
                   
               
               
                 42 
                 HGL6.85 
                 HGL6.980, 
                 GGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATCGAAGAGAA 
               
               
                   
                   
                 HGL6.1002 
                 TCATCGAATGGACC (SEQ ID NO: 48) 
               
               
                   
               
               
                 43 
                 HGL6.88 
                   
                 AACACGACTTTGAGAAGAGTAAGTGATTGTTAATTAAAGCAAGAGAATTATTGA 
               
               
                   
                   
                   
                 TGTATCACAGTCATGAGAAATATTGGAAGGAATATGGTCCATAC (SEQ ID NO: 49) 
               
               
                   
               
               
                 44 
                 HGL6.91 
                   
                 TGAAAAGAAGAATGACCATAAGCAAGCAGATGAAAAACAAAACAGAATTTTTA 
               
               
                   
                   
                   
                 CAGACGTCTTGGACTGATATCTTGGGC (SEQ ID NO: 50) 
               
               
                   
               
               
                 45 
                 HGL6.92 
                   
                 AATCAATAAATGTAAACCAGCATATAAACAGAACCAACGACAAAAACCACATGA 
               
               
                   
                   
                   
                 TTATCTCAATAGATGCAGAAAAGGCC (SEQ ID NO: 51) 
               
               
                   
               
               
                 46 
                 HGL6.95 
                   
                 CAACATCAAACGGAATCAAACGGAATTATCGAATGGAATCGAAGAGAATCATCG 
               
               
                   
                   
                   
                 AATGGACTCGAATGGAATCATCTAATGGAATGGAATGGAAG (SEQ ID NO: 52) 
               
               
                   
               
               
                 47 
                 HGL6.96 
                   
                 AATGGAAGGGAATGGAATGGAATCGAATCGAATGGAACAGAATTCAATGGAAT 
               
               
                   
                   
                   
                 GGAATGGAATGGAATGGAATCGAATGGAATGG (SEQ ID NO: 53) 
               
               
                   
               
               
                 48 
                 HGL6.100 
                   
                 AAAGACTTAAACATAAGACCTAAAACCATAAAAACCACAGAAGAAAACATAGG 
               
               
                   
                   
                   
                 CAATGCCATTCAGGACATAGGCATGGGCAAAGACTTC (SEQ ID NO: 54) 
               
               
                   
               
               
                 49 
                 HGL6.101 
                   
                 AGACTTGAAAAGCACAGACAACGAAAGCAAAAATGGACAAATGGAATCACATC 
               
               
                   
                   
                   
                 AAGCTAAAAGGTTTTGCATGGCAAAGG (SEQ ID NO: 55) 
               
               
                   
               
               
                 50 
                 HGL6.1l2 
                 HGL6.952, 
                 AGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGTGCAAAAATCACAAGCA 
               
               
                   
                   
                 HGL6.955 
                 TTCTTATACACCAACAACAGACAAACAGAGAGCC (SEQ ID NO: 56) 
               
               
                   
               
               
                 51 
                 HGL6.113 
                   
                 TGAATGCTATAGAGCAGTAAAAACAAATAAATGAACTACATTACAGCTACTTAC 
               
               
                   
                   
                   
                 AACCATATGAAAGAATATAACCATAACAATGATGAGTGGACAAAAGCTAAGTGT 
               
               
                   
                   
                   
                 GAAAGAATGCATAGTGCTACAGCAGCCAACATTTACAGC (SEQ ID NO: 57) 
               
               
                   
               
               
                 52 
                 HGL6.115 
                   
                 AACAAAATTGAACAACATGCAAAGAAACATAAACGAAGCAATGAAAGTGTGCA 
               
               
                   
                   
                   
                 GATCCACTGAAATGAAAGTGCTGTCCAGAGTGGGAGCCAGCTCGAGA (SEQ ID 
               
               
                   
                   
                   
                 NO: 58) 
               
               
                   
               
               
                 53 
                 HGL6.116 
                   
                 TGGAATTATCGTCGAATAGAATCGAATGGTATCAACATCAAACGGAAAAAAACG 
               
               
                   
                   
                   
                 GAATTATCGAATGGAATCGAAGAGAATCATCGAACGGACTCGAATGGAATCATC 
               
               
                   
                   
                   
                 TAATGGAATGGAATGGAATAATCCATGG (SEQ ID NO: 59) 
               
               
                   
               
               
                 54 
                 HGL6.117 
                   
                 AGATAAGTGGATGAACAGATGGACAGATGGATGGATGGATGGATGGATGGATG 
               
               
                   
                   
                   
                 GATGCCTGGAAGAAAGAAGAATGGATAGTAAGCTGGGTATA (SEQ ID NO: 60) 
               
               
                   
               
               
                 55 
                 HGL6.119 
                   
                 AATCAAAGAATTGAATCGAATGGAATCATCTAATGTACTCGAATGGAATCACCA 
               
               
                   
                   
                   
                 T (SEQ ID NO: 61) 
               
               
                   
               
               
                 56 
                 HGL6.121 
                   
                 AATGGAATCGAACGGAATCATCATCAAACGGAACCGAATGGAATCATTGAATGG 
               
               
                   
                   
                   
                 AATCAAAGGCAATCATGGTCGAATG (SEQ ID NO: 62) 
               
               
                   
               
               
                 57 
                 HGL6.122 
                   
                 AGGAATCTATAATACAGCTGTTTATAGCCAAGCACTAAATCATATGATACAGAA 
               
               
                   
                   
                   
                 AACAAATGCAGATGGTTTGAAGGGTGGG (SEQ ID NO: 63) 
               
               
                   
               
               
                 58 
                 HGL6.125 
                   
                 AACGGAAAAAAACGGAATTATCGAATGGAATCGAAGAGAATCATCGAATGGAC 
               
               
                   
                   
                   
                 C (SEQ ID NO: 64) 
               
               
                   
               
               
                 59 
                 HGL6.126 
                   
                 TGAGAAAATGATGGAAAAGAGGAATAANACGAAACAAAACCACAGGAACACAG 
               
               
                   
                   
                   
                 GTGCATGTGAATGTGCACAGACAAAGATACAGGGCGGACTGGGAAGGAAGTTTC 
               
               
                   
                   
                   
                 TGCACCAGAATTTGGGG (SEQ ID NO: 65) 
               
               
                   
               
               
                 60 
                 HGL6.132 
                   
                 AATGGAATCGAAGAGAATGGAAACAAATGGAATGGAATTGAATGGAATGGAAT 
               
               
                   
                   
                   
                 TGAATGGAATGGGAAGGAATGGAGTG (SEQ ID NO: 66) 
               
               
                   
               
               
                 61 
                 HGL6.134 
                   
                 AATGTCAAGTGGAATCGAGTGGAATCATCGAAAGAAATCGAATGGAATCGAAGG 
               
               
                   
                   
                   
                 GAATCATTGGATGGGCTCAAAT (SEQ ID NO: 67) 
               
               
                   
               
               
                 62 
                 HGL6.137 
                   
                 AAACAATGGAAGATAATGGAAAGATATCGAATGGAATAGAATGGAATGGAATG 
               
               
                   
                   
                   
                 GACTCAAATGGAATGGACTTTAATGGAATGG (SEQ ID NO: 68) 
               
               
                   
               
               
                 63 
                 HGL6.138 
                   
                 GAACAATCAATGGAAGCAGAAACAAATAAACCAAGGTGTGCATCAAGGAATAC 
               
               
                   
                   
                   
                 ATTCACGCATGATGGCTGTATGAGTAAAATG (SEQ ID NO: 69) 
               
               
                   
               
               
                 64 
                 HGL6.139 
                   
                 AAACCGAATGGAATGGAATGGACGCAAAATGAATGGAATGGAAGTCAATGGAC 
               
               
                   
                   
                   
                 TCGAAATGAATGGAATGGAATGGAATGGAATG (SEQ ID NO: 70) 
               
               
                   
               
               
                 65 
                 HGL6.140 
                   
                 AGGATACAAAATCAAAGTGCAAAAATCACAAGCATTCTTATACACCAATAACAG 
               
               
                   
                   
                   
                 ACAAACAGAGAGCC (SEQ ID NO: 71) 
               
               
                   
               
               
                 66 
                 HGL6.147 
                   
                 GGAATCGAATGGAATCAACATCAAACGGAAAAAAACAGAATTATCGTATGGAAT 
               
               
                   
                   
                   
                 CGAATAGAATCATCGAATGGACC (SEQ ID NO: 72) 
               
               
                   
               
               
                 67 
                 HGL6.148 
                   
                 CAACCCGAGTGGAATAAAATGGAATGGAATGGAATGAAATGGAATGGATCGGA 
               
               
                   
                   
                   
                 ATGGAATCCAATGGAATCAACTGGAATGGAATGGAATGGAATG (SEQ ID NO: 73) 
               
               
                   
               
               
                 68 
                 HGL6.149 
                   
                 TATCATCGAATGGAATCGAATGGAATCAACATCAAACGGAAAAAAACGGAATTA 
               
               
                   
                   
                   
                 TCGAATGGAATCGAAGAGAATCATCGAATGGACC (SEQ ID NO: 74) 
               
               
                   
               
               
                 69 
                 HGL6.150 
                   
                 CGGAATAATCATTGAACGGAATCGAATGGAATCATCATCGGATGGAAACGAATG 
               
               
                   
                   
                   
                 GAATCATCATCGAATGGAAATGAAAGGAGTCATC (SEQ ID NO: 75) 
               
               
                   
               
               
                 70 
                 HGL6.151 
                   
                 CAACACACAGAGATTAAAACAAACAAACAAACAATCCAGCCCTGACATTTATGA 
               
               
                   
                   
                   
                 GTTTACAGACTGGTGGAGAGGCAGAGAAG (SEQ ID NO: 76) 
               
               
                   
               
               
                 71 
                 HGL6.152 
                   
                 GGAATGGAATGAACACGAATGTAATGCAACCCAATAGAATGGAATCGAATGGCA 
               
               
                   
                   
                   
                 TGGAATATAAAGAAATGGAATCGAAGAGAATGGAAACAAATGGAATGGAATTG 
               
               
                   
                   
                   
                 (SEQ ID NO: 77) 
               
               
                   
               
               
                 72 
                 HGL6.153 
                   
                 CACTACAAACCACGCTCAAGGCAATAAAAGAACACAAACAAATGGAAAAACAT 
               
               
                   
                   
                   
                 TCCATGCTCATGGATGGG (SEQ ID NO: 78) 
               
               
                   
               
               
                 73 
                 HGL6.158 
                   
                 AATCGAATGGAATTAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATCG 
               
               
                   
                   
                   
                 AAGAGAATCATCGAATGGACC (SEQ ID NO: 79) 
               
               
                   
               
               
                 74 
                 HGL6.161 
                   
                 TGGAAAAGAATCAAATTGAATGGCATCGAACGGAATGGGATGGAATGGAATAG 
               
               
                   
                   
                   
                 ACCCAGATGTAATGGACTCGAATGGAATG (SEQ ID NO: 80) 
               
               
                   
               
               
                 75 
                 HGL6.163 
                   
                 AATCAGTCTAGATCTTAAAGGAACACCAGAGGGAGTATTTAAATGTGCCCAATA 
               
               
                   
                   
                   
                 AGCAAGAATTATGGTGATGTGGAAGTA (SEQ ID NO: 81) 
               
               
                   
               
               
                 76 
                 HGL6.164 
                   
                 CCATAACACAATTAAAAACAACCTAAATGTCTAATAGAAGAACACTGTTCAGAC 
               
               
                   
                   
                   
                 CGGGCATGGTGGCTTATACC (SEQ ID NO: 82) 
               
               
                   
               
               
                 77 
                 HGL6.165 
                   
                 GACTAATATTCAGAATATACAAGGAACTCAAACAACTCAACAGTAGAAAAAAAA 
               
               
                   
                   
                   
                 ACCTGAATAGACATTTCTCAAAAGAAGACATACAAATGGCC (SEQ ID NO :33) 
               
               
                   
               
               
                 78 
                 HGL6.171 
                 HGL6.1149 
                 AACAGACCATAAATAAACACAGAAGACACACGAGTGTAAAGTCAGTGCCCCGCT 
               
               
                   
                   
                   
                 GCGAATTAAATCGGGGTGATGTGATGGCGAGTGAGTGGGTAGTT (SEQ ID NO: 
               
               
                   
                   
                   
                 84) 
               
               
                   
               
               
                 79 
                 HGL6.174 
                   
                 ATCATTGAATGCAATCACATGGAATCATCACAGAATGGAATCGTACGGAATCAT 
               
               
                   
                   
                   
                 CATCGAATGGAATTGAATGGAATCATCAATTGGACTCGAATGGAAACATCAAAT 
               
               
                   
                   
                   
                 GGAATCGATTGGAAGTGTCGAATGGACTCG (SEQ ID NO: 85) 
               
               
                   
               
               
                 80 
                 HGL6.175 
                   
                 GGTCCATTCGATGATTCTCTTCGATTCCATTCGATAATTCCGTTTTTTCCCGTTTG 
               
               
                   
                   
                   
                 ATGTTGATTCC (SEQ ID NO: 86) 
               
               
                   
               
               
                 81 
                 HGL6.178 
                   
                 AGCAACTTCAGTAAAGTGTCAGGATACAAAATCAATGTGCAAAAATCACAAGCA 
               
               
                   
                   
                   
                 TTCTTATACATCAATAACAGACAAACAGAGAGCCAAA (SEQ ID NO: 87) 
               
               
                   
               
               
                 82 
                 HGL6.180 
                   
                 AGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGTGCAAAAATCACAAGCA 
               
               
                   
                   
                   
                 TTCCTATACACCAACAACAGACAAACAGAGAGCC (SEQ ID NO: 88) 
               
               
                   
               
               
                 83 
                 HGL6.181 
                   
                 GAATAATCATTGAACGGAATCGAATGGAATCATCATCGGATGGAAACGAATGGA 
               
               
                   
                   
                   
                 ATCATCATCGAATGGAAATGAAAGGAGTCATC (SEQ ID NO: 89) 
               
               
                   
               
               
                 84 
                 HGL6.182 
                 HGL6.902 
                 TAATCAT CT TCGAATTGAAAACAAAGCAATCATTAAATGTACTCTAACGGAATCA 
               
               
                   
                   
                   
                 TCGAATGGACC (SEQ ID NO: 90) 
               
               
                   
               
               
                 85 
                 HGL6.184 
                 HGL6.1215 
                 GGAATCGAATGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAA 
               
               
                   
                   
                   
                 TCGAAGAGAATCATCGAATGGACC (SEQ ID NO: 91) 
               
               
                   
               
               
                 86 
                 HGL6.186 
                   
                 GATCAGCTTAGAATACAATGGAACAGAACAGATTAGAACAATGTGATTTTATTA 
               
               
                   
                   
                   
                 GGGGCCACAGCACTGTTGACTCAAGTACAAGTTCTGACTCATGTAGAACTAACA 
               
               
                   
                   
                   
                 CTTTT (SEQ ID NO: 92) 
               
               
                   
               
               
                 87 
                 HGL6.187 
                   
                 AGAGAAAAGATGATCATGTAACCATTGAAAAGACAATGTACAAAACTAATACTA 
               
               
                   
                   
                   
                 ATCACACAGGACCAGAAAGCAATTTAGACCAT (SEQ ID NO: 93) 
               
               
                   
               
               
                 88 
                 HGL6.190 
                   
                 AATGGAATCGAATGGAATCAACATCAAACGGAAAAAACGGAATTATCGAATGG 
               
               
                   
                   
                   
                 AATCAAAGAGAATCATCGAATGGACC (SEQ ID NO: 94) 
               
               
                   
               
               
                 89 
                 HGL6.191 
                   
                 AATGGAATTATCATCGAATGGAATCGAATGGAATCAACATCAAACGGAAAAAAA 
               
               
                   
                   
                   
                 CGGAATTATCGAATGGAATCGAAGAGAATCATCGAATGGACC (SEQ ID NO: 95) 
               
               
                   
               
               
                 90 
                 HGL6.197 
                   
                 GTCAACACAGGACCAACATAGGACCAACACAGGGTCAACACAGGACCAACATA 
               
               
                   
                   
                   
                 GGACCAACACAGGGTCAACACAAGACCAACATGGGACCAACACAGGGTCAACA 
               
               
                   
                   
                   
                 TAGGACCAACATGGGACCAACACAGGGTCAACACAGGACCAAC (SEQ ID NO: 96) 
               
               
                   
               
               
                 91 
                 HGL6.198 
                   
                 TATAGTTGAATGAACACACATACACACACACATGCCACAAAACAAAAACAAAGT 
               
               
                   
                   
                   
                 TATCCTCACACACAGGATAGAAACCAAACCAAATCCCAACACATGGCAAGATGA 
               
               
                   
                   
                   
                 T (SEQ ID NO: 97) 
               
               
                   
               
               
                 92 
                 HGL6.206 
                   
                 GAATCAACTCGATTGCAATCGAATGGAATGGAATGGTATTAACAGAATAGAATG 
               
               
                   
                   
                   
                 GAATGGAATGGAATGGAACGGAACG (SEQ ID NO: 98) 
               
               
                   
               
               
                 93 
                 HGL6.208 
                   
                 AATGGAATGGAATAATCGACGGACCCGAATGCAATCATCATCGTACAGAATCGA 
               
               
                   
                   
                   
                 ATGGAATCATCGAATGGACTGGAATGGAATGG (SEQ ID NO: 99) 
               
               
                   
               
               
                 94 
                 HGL6.210 
                   
                 AATACAAACCACTGCTCAACGAAATAAAAGAGGATACAAACAAATGGAAGAAC 
               
               
                   
                   
                   
                 ATTCTATGCTCATGGGTAGGATGAATTCATATCGTGAAAATGGCCATACTGCC 
               
               
                   
                   
                   
                 (SEQ ID NO: 100) 
               
               
                   
               
               
                 95 
                 HGL6.215 
                   
                 AAACACGCAAACACACACACAAGCACACTACCACACAAGCGGACACACATGCA 
               
               
                   
                   
                   
                 AACACGCGAACACACACACATATACACACAAGCACATTACAAAACACAAGCAA 
               
               
                   
                   
                   
                 ACACCAGCAGACACACAAACACACAAACATACATGG (SEQ ID NO: 101) 
               
               
                   
               
               
                 96 
                 HGL6.219 
                   
                 AATCGAACGGAATCAACATCAAACGGAAAAAAAACGGAATTATCGAATGGAAT 
               
               
                   
                   
                   
                 CGAAGAGAATCATCGAATGGACC (SEQ ID NO: 102) 
               
               
                   
               
               
                 97 
                 HGL6.220 
                 HGL6.301, 
                 ACACATTTCAAGGAAGGAAACAAGAACAGACAGAAACACAACATACTTCATGA 
               
               
                   
                   
                 HGL6.1353 
                 AACCACATTTTAGCATCCTGGCCGAGTATTCATCA (SEQ ID NO: 103) 
               
               
                   
               
               
                 98 
                 HGL6.222 
                   
                 GGATACAAAATCAATGTACAAAAATCACAAGCATTCTTATACACCAATAACAGA 
               
               
                   
                   
                   
                 CAAACAGAGAGCC (SEQ ID NO: 104) 
               
               
                   
               
               
                 99 
                 HGL6.223 
                   
                 TAATTGATTCGAATGGAATGGAATAGAATGGAATTGAATGGAATGGACCATAAT 
               
               
                   
                   
                   
                 GGATTGGACTTTAATAGAAAGGGCATG (SEQ ID NO: 105) 
               
               
                   
               
               
                 100 
                 HGL6.225 
                   
                 AGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGTACAAAAGTCACAAGCA 
               
               
                   
                   
                   
                 TTCTTATACACCAACAAAAGACAAACAGAGAGCC (SEQ ID NO: 106) 
               
               
                   
               
               
                 101 
                 HGL6.228 
                   
                 ACATCAAACGGAAAAAAAAAACAAAACGGAATTATCGAATGGAATCGAAGAGA 
               
               
                   
                   
                   
                 ATCATCGAATGGACC (SEQ ID NO: 107) 
               
               
                   
               
               
                 102 
                 HGL6.229 
                   
                 ACATCTCACTTTTAGTAATGAACAGATCATTCAGACAGAAAATTAGCAAAGAAA 
               
               
                   
                   
                   
                 CATCAGAGTTAAACTACACTCTAAACCAAATGGACCTA (SEQ ID NO: 108) 
               
               
                   
               
               
                 103 
                 HGL6.231 
                   
                 GAAGAAAGCATTCATTCAAGACATCTAACTCGTTGATATAATGCATACAGTTCAA 
               
               
                   
                   
                   
                 AATGATTACACTATCATTACATCTAGGGCTTTC (SEQ ID NO: 109) 
               
               
                   
               
               
                 104 
                 HGL6.232 
                   
                 GCAAAAGAAACAATCAGTAGAGTAAACAGACAACTCATAGAATGCAAGAAAAT 
               
               
                   
                   
                   
                 CATCGCAATCTGTACATCCAACAAAGGGCT (SEQ ID NO: 110) 
               
               
                   
               
               
                 105 
                 HGL6.235 
                   
                 ACACACACATTCAAAGCAGCAATATTTACAACAGCCAAAAGGTGGAAACAATTG 
               
               
                   
                   
                   
                 AGCAATTG (SEQ ID NO: 111) 
               
               
                   
               
               
                 106 
                 HGL6.237 
                   
                 ATCATCGAATAGAATCGAATGGTATCAACACCAAACGGAAAAAAACGGAATTAT 
               
               
                   
                   
                   
                 CGAATGGAATCGAAGAGAATCTTCGAACGGACC (SEQ ID NO: 112) 
               
               
                   
               
               
                 107 
                 HGL6.238 
                   
                 TGAAAATACAAATGACCATGCAAGTAATTCCGCAGGGAGAGAGCGGATATGAAC 
               
               
                   
                   
                   
                 AAACAGAAGAAATCAGATGGGATAGTGCTGGCGGGAAGTCA (SEQ ID NO: 113) 
               
               
                   
               
               
                 108 
                 HGL6.239 
                   
                 AATCGAAAGGAATGTCATCGAATGGAATGGACTCAAATGGAATAGAATCGGATG 
               
               
                   
                   
                   
                 GAATGGCATCGAATGGAATGGAATGGAATTGGATGGAC (SEQ ID NO: 114) 
               
               
                   
               
               
                 109 
                 HGL6.241 
                   
                 AACATGAACAGTGGAACAATCAGTGAACCAATACAAGGGTTAAATAAGCTAGCA 
               
               
                   
                   
                   
                 ATTAAAAGCTGTATCACTGGTCTAAAGATAGAAGATCAAGTAGAAAATCAGCGC 
               
               
                   
                   
                   
                 AAGAGGAAAGATATACGAAAACTAATGGCC (SEQ ID NO: 115) 
               
               
                   
               
               
                 110 
                 HGL6.243 
                   
                 CGAATGGAATCATTATGGAATGGAATGAAATGGAATAATCAAATGGAATTGAAT 
               
               
                   
                   
                   
                 GGAATCATCGAATGGAATCGAACAAAATCCTCTTTGAATGGAATAAGATGGAAT 
               
               
                   
                   
                   
                 CACCAAATGGAATTG (SEQ ID NO: 116) 
               
               
                   
               
               
                 111 
                 HGL6.246 
                   
                 AAACGGAATCAAACGGAATTATCGAATGGAATCGAAGAGAATCATCGAACGGA 
               
               
                   
                   
                   
                 CTCGAATGGAATCATCTAATGGAATGGAATGGAAGAATCCATGGACT (SEQ ID 
               
               
                   
                   
                   
                 NO: 117) 
               
               
                   
               
               
                 112 
                 HGL6.247 
                   
                 GCTAGTTCAACATATGCAAATCAATAAACGTAATCCATCACATAAACAGAACCA 
               
               
                   
                   
                   
                 ATGACAAAAACCACGATTATCTCAATAGATGCAGAAAAGGCC (SEQ ID NO: 118) 
               
               
                   
               
               
                 113 
                 HGL6.256 
                   
                 ACCAATCAAGAAAACAATGCAACCCACAGAGAATGGACAAAAGCAAGGCAGGA 
               
               
                   
                   
                   
                 CAATGGCT (SEQ ID NO: 119) 
               
               
                   
               
               
                 114 
                 HGL6.26 
                   
                 ATCGAATGGAATCAACATCAGACGGAAAAAAACGGAATTATCAAATGGAATCGA 
               
               
                   
                   
                   
                 AGAGAATCATCGAATGGACC (SEQ ID NO: 120) 
               
               
                   
               
               
                 115 
                 HGL6.260 
                   
                 ATGGAATCAACATCAAACGGAAAAAAAAACGGAATTATCGAATGGAATCGAAG 
               
               
                   
                   
                   
                 AGAATCATCGAATGGACCAGAATGGAATCATCTAATGGAATGGAATGG (SEQ ID 
               
               
                   
                   
                   
                 NO: 121) 
               
               
                   
               
               
                 116 
                 HGL6.261 
                 HGL6.1088 
                 AATGGAATCATCATCGAATGGAATCGAATGGAATCATGGAATGGAATCAAATGG 
               
               
                   
                   
                   
                 AATCAAATGGAATCGAATGGAATGGAATGGAATG (SEQ ID NO: 122) 
               
               
                   
               
               
                 117 
                 HGL6.262 
                   
                 AACGGAATCAAACGGAATTACCGAATGGAATCGAATAGAATCATCGAACGGACT 
               
               
                   
                   
                   
                 CGAATGGAATCATCTAATGGAATGGAATGGAAG (SEQ ID NO: 123) 
               
               
                   
               
               
                 118 
                 HGL6.263 
                   
                 AAACGGAATCAAACGGAATTATCGAATGGAATCGAAAAGAATCATCGAACGGA 
               
               
                   
                   
                   
                 CTCGAATGGAATCATCTAATGGAATGGAATGGAAGAATCCATGG (SEQ ID NO:  
               
               
                   
                   
                   
                 124) 
               
               
                   
               
               
                 119 
                 HGL6.266 
                   
                 AGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGTACAAAAATCACAAGCA 
               
               
                   
                   
                   
                 TTCTTATACACCAATAACAGACAAACAGAGAGCC (SEQ ID NO: 125) 
               
               
                   
               
               
                 120 
                 HGL6.267 
                   
                 GAATGATACGGANTANNNNGNAATGGAACGAAATGAAATGGAATGGAATGGAA 
               
               
                   
                   
                   
                 TGGAATGGAATGGAATGG (SEQ ID NO: 126) 
               
               
                   
               
               
                 121 
                 HGL6.268 
                   
                 AATGGACTCGAATGGATTAATCATTGAACGGAATCGAATGGAATCATCATCGGA 
               
               
                   
                   
                   
                 TGGTAATGAATGGAATCATCATCGAATGGAATCGG (SEQ ID NO: 127) 
               
               
                   
               
               
                 122 
                 HGL6.271 
                   
                 GAATGGAATCGAAAGGAATGTCATCGAATGGAATGGAATGGAACGGAATGGAA 
               
               
                   
                   
                   
                 TCGAATGGAATGGACTCGAATGGAATAGAATCGAATGCAATGGCATCG (SEQ ID 
               
               
                   
                   
                   
                 NO: 128) 
               
               
                   
               
               
                 123 
                 HGL6.274 
                 HGL6.466, 
                 GAATAGAATAGAATGGAATCATCGAATGGAATCGAATGGAATCATCATGATATG 
               
               
                   
                   
                 HGL6.883 
                 GAATTGAGTGGAATC (SEQ ID NO: 129) 
               
               
                   
               
               
                 124 
                 HGL6.276 
                   
                 TAAGCCGATAAGCAACTTCAGCAAAGTCTCAGGAGACAAAATCAATGTGCAAAA 
               
               
                   
                   
                   
                 AATCACAAGCATTCTTATACACTAATAACAGACAAACAGAGAGCCAAATCATG 
               
               
                   
                   
                   
                 (SEQ ID NO: 130) 
               
               
                   
               
               
                 125 
                 HGL6.277 
                   
                 AGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGTGCAAAAATCAAAAGCA 
               
               
                   
                   
                   
                 TTCTTATGCACCAATAACAGACACAGAGCCAAAT (SEQ ID NO: 131) 
               
               
                   
               
               
                 126 
                 HGL6.278 
                   
                 AGGAAAGTTTTCAATATGAGAAAGATACAAACCAACAGAATAAGCAAACTGGAT 
               
               
                   
                   
                   
                 AAACAGAAAATACAGAGAGAGCCAAGG (SEQ ID NO: 132) 
               
               
                   
               
               
                 127 
                 HGL6.280 
                   
                 AATGGAATGGAACGCAATTGAATGGAATGGAATGGAACGGAATCAACCTGAGTC 
               
               
                   
                   
                   
                 AAATGGAATGGAATGGAATGGAATG (SEQ ID NO: 133) 
               
               
                   
               
               
                 128 
                 HGL6.289 
                   
                 AGGAAAATGCAAATCAGAACGACTATAACACACCATCTCAAACTCGTTAGGATG 
               
               
                   
                   
                   
                 GCTATTATCAAAAAGTCAAGAGATAACAAATGTGGGCAAGGG (SEQ ID NO: 134) 
               
               
                   
               
               
                 129 
                 HGL6.290 
                   
                 GGAACGAAATCGAATGGAACGGAATAGAATAGACTCGAATGTCATGGATTGCTA 
               
               
                   
                   
                   
                 TGTAATTGATTGGAATGGAATGGAATCG (SEQ ID NO: 135) 
               
               
                   
               
               
                 130 
                 HGL6.291 
                   
                 GAATTGAAAGGAATGTATTGGAATAAAATGGAATCGAATAGGTTGAAATACCAT 
               
               
                   
                   
                   
                 AGGTTCGAATTGAATGGAATGGGAGGGACACCAATGGAATTG (SEQ ID NO: 136) 
               
               
                   
               
               
                 131 
                 HGL6.292 
                   
                 AACAAAACAAAAACCCAACTCAATAACAAGAAGACAAACAACCCAATTTAAAA 
               
               
                   
                   
                   
                 TGAGCAAAGAACTTGATAAACATGTCTCCAAAGAAGATACGGCCAAAGAGCAC 
               
               
                   
                   
                   
                 (SEQ ID NO: 137) 
               
               
                   
               
               
                 132 
                 HGL6.295 
                   
                 ATGGTTAAAACTCAACAATGAAAACACAAACAGCGCAATTTAAAAATGGGCAAA 
               
               
                   
                   
                   
                 ATGACAGGCCAGACCCAGTGGCTCATGCG (SEQ ID NO: 138) 
               
               
                   
               
               
                 133 
                 HGL6.300 
                   
                 AAGCAACTTCAGCAAAGTCTCGGGATACAAAATCAATGTGCAAAAATCACAAGC 
               
               
                   
                   
                   
                 ATTCTTATACACCACTAACAGACAAATGGAGAGTC (SEQ ID NO: 139) 
               
               
                   
               
               
                 134 
                 HGL6.302 
                   
                 GAATGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATCGAAG 
               
               
                   
                   
                   
                 AGAATCATCGAATGGACCAGAATGGAATCATCTAATGGAATGGAATGGAATAAT 
               
               
                   
                   
                   
                 CCATGG (SEQ ID NO: 140) 
               
               
                   
               
               
                 135 
                 HGL6.305 
                   
                 TAGAAGGAATTTGATACATGCTCAGAAATACAGGCAAAGGAAGTAGGTGCCTGC 
               
               
                   
                   
                   
                 CAGTGAACACAGGGGAACTATGGCTCCTA (SEQ ID NO: 141) 
               
               
                   
               
               
                 136 
                 HGL6.310 
                   
                 GGAATCGAATGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAA 
               
               
                   
                   
                   
                 TCGAAGAGAATCATCGAATGGACC (SEQ ID NO: 142) 
               
               
                   
               
               
                 137 
                 HGL6.311 
                   
                 AACTAAGACAACAGATTGATTTACACTACTATTTTCACACAGCCAAAAATATCAC 
               
               
                   
                   
                   
                 TATGGCAATCGTCAAAAGGTCAATTCAAAGATGGGACAGT (SEQ ID NO: 143) 
               
               
                   
               
               
                 138 
                 HGL6.315 
                   
                 AAAAGCAATTGGACTGATTTTAAATATACGTGGCAACAAGGATAAACTGCTAAT 
               
               
                   
                   
                   
                 GATGGGTTTGCAAATACAGATCG (SEQ ID NO: 144) 
               
               
                   
               
               
                 139 
                 HGL6.317 
                 HGL6.1189 
                 AATGGAATCAACATCGAACGGAAAAAAACGGAATTATCGAATGGAATCGAAGA 
               
               
                   
                   
                   
                 GAATCATCGAATGGACC (SEQ ID NO: 145) 
               
               
                   
               
               
                 140 
                 HGL6.319 
                   
                 TGCAAGATAACACATTTTAGTTGACACCATTGAAAACAGTTTTAACCAAGAATAT 
               
               
                   
                   
                   
                 TAGAACCAATGAAGCAGAGAAATCAAAAGGGTGGATGGAACTGCCAAAGGATG 
               
               
                   
                   
                   
                 (SEQ ID NO: 146) 
               
               
                   
               
               
                 141 
                 HGL6.321 
                   
                 TAGAACAGAATTGAATGGAATGGCATCAAATGGAATGGAAACGAAAGGAATGG 
               
               
                   
                   
                   
                 AATTGAATGGACTCAAATGTTATGGAATCAAAGGGAATGGACTC (SEQ ID NO: 
               
               
                   
                   
                   
                 147) 
               
               
                   
               
               
                 142 
                 HGL6.323 
                   
                 AAGAGAATCATCGAATGGAATCGAATGGAATCAACATCAAACGGAAAAAAACG 
               
               
                   
                   
                   
                 GAATTATCGAATGGAATCGAAGAGAATCATCGAATGGACC (SEQ ID NO: 148) 
               
               
                   
               
               
                 143 
                 HGL6.324 
                 HGL6.431, 
                 ATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATCGAAGAGAATCAT 
               
               
                   
                   
                 HGL6.1071 
                 CGAATGGACC (SEQ ID NO: 149) 
               
               
                   
               
               
                 144 
                 HGL6.326 
                   
                 GAATCAACATCAAACGGAAAAAAACCGAATTATCGAATGGAATCGAAGAGAAT 
               
               
                   
                   
                   
                 CATCGAATGGACC (SEQ ID NO: 150) 
               
               
                   
               
               
                 145 
                 HGL6.327 
                   
                 ATCAACATCAAACGGAATCAAACGGAATTATCGAATGGAATCGAAGAGAATCAT 
               
               
                   
                   
                   
                 CAAATGGACTCGAATGGAATCATCTAATGGAATGGAATGGAAGAATCCATGG 
               
               
                   
                   
                   
                 (SEQ ID NO: 151) 
               
               
                   
               
               
                 146 
                 HGL6.330 
                 HGL6.1005 
                 AAACAGTTCAAAAATTATTGCAACAAAATGAGAGAGATGAGTTTATCTTGCAAA 
               
               
                   
                   
                   
                 CTAATGGATGGTAGCAGTGACAGTGGCAAAACGTGGTTTGATTCT (SEQ ID NO: 
               
               
                   
                   
                   
                 152) 
               
               
                   
               
               
                 147 
                 HGL6.334 
                   
                 ATCGAATGGAATCATTGAATGGAAAGGAATGGAATCATCATGGAATGGAAACGA 
               
               
                   
                   
                   
                 ATGGAATCACTGAATGGACTCGAATGGGATCATCA (SEQ ID NO: 153) 
               
               
                   
               
               
                 148 
                 HGL6.335 
                   
                 ATTCAGCCTTTAAAAAAAGAAGACAGTCCTGTCATTTGTGACAATATGAATGAA 
               
               
                   
                   
                   
                 ACAGACATCACATTAAATGAAATGAGCCAGGCGCAG (SEQ ID NO: 154) 
               
               
                   
               
               
                 149 
                 HGL6.336 
                   
                 AGGAGAATAGCAGTAGAATGACAAAATTAGATTTTCACATGAAACTTGATGACA 
               
               
                   
                   
                   
                 GTGTAGGAAATGGACTGAAAGGACAAGAC (SEQ ID NO: 155) 
               
               
                   
               
               
                 150 
                 HGL6.337 
                 HGL6.1095, 
                 AACCCACAAAGACAACAGAAGAAAAGACAACAGTAGACAAGGATGTCAACCAC 
               
               
                   
                   
                 HGL6.1367 
                 ATTTTGGAAGAGACAAGTAATCAAACACATGGCA (SEQ ID NO: 156) 
               
               
                   
               
               
                 151 
                 HGL6.338 
                   
                 GAAAATGAACAATATGAACAAACAAACAAAATTACTACCCTTACGAAAGTACGT 
               
               
                   
                   
                   
                 GCATTCTAGTATGGTGACAAAAAGGAAAG (SEQ ID NO: 157) 
               
               
                   
               
               
                 152 
                 HGL6.339 
                   
                 AACATCAAACGGAATCAAACGGAATTATCGAATGGAATCGAAGAGAATCATCGA 
               
               
                   
                   
                   
                 ACGGACTCGAATGGAATCATCTAATGGAATGGAATGGAAGAATCCATGGACTCG 
               
               
                   
                   
                   
                 AATGCAATCATCATCGAATGAAATCGAATGGAATCATCGAATGGACTCG (SEQ ID 
               
               
                   
                   
                   
                 NO: 158) 
               
               
                   
               
               
                 153 
                 HGL6.340 
                   
                 ACCAACATAAGACAAAGAAACATCCAGCAGCTGCCTATGGCAAAAGATTACAAT 
               
               
                   
                   
                   
                 GTGTCAAACAAGAGGGCAATG (SEQ ID NO: 159) 
               
               
                   
               
               
                 154 
                 HGL6.342 
                   
                 ATGGAATTCAATGGAATGGACATGANTGNAATGNACTTCAATGGAATGGNATCN 
               
               
                   
                   
                   
                 AATGGAATGNAATTCANT (SEQ ID NO: 160) 
               
               
                   
               
               
                 155 
                 HGL6.343 
                   
                 TATGACTTTCACAAATTACAGAAAAAGACACCCATTTGACAAGGGAACTGAAGG 
               
               
                   
                   
                   
                 TGGTGAAGACATACTGGCAGGCTAC (SEQ ID NO: 161) 
               
               
                   
               
               
                 156 
                 HGL6.344 
                   
                 AATGGAAAGGAATCGAATGGAAGGGAATGAAATTGAATCAACAGGAATGGAAG 
               
               
                   
                   
                   
                 GGAATAGAATAGACGGCAATGGAATGGACTCG (SEQ ID NO: 162) 
               
               
                   
               
               
                 157 
                 HGL6.347 
                   
                 AGCCTATCAAAAAGTGGGCTAAGAATATGAATACACAATTCTCAAAAGAAGATA 
               
               
                   
                   
                   
                 TACAAATGGGCAACAAACATATGAAAACATACTCAACATCACTAATGATCAGGG 
               
               
                   
                   
                   
                 AAATG (SEQ ID NO: 163) 
               
               
                   
               
               
                 158 
                 HGL6.352 
                 HGL6.710 
                 AGCAACTTCAGCAAAGTATCAGGATACAAAATCAATGTACAAAAATCCCAAGCA 
               
               
                   
                   
                   
                 TTCTTATACACCAACAACAGACAAACAGAGAGCC (SEQ ID NO: 164) 
               
               
                   
               
               
                 159 
                 HGL6.353 
                   
                 AAAGACAATATACAAATGGCCAATAAGCACATGAAAAGACGCTCAACATCCTTA 
               
               
                   
                   
                   
                 GTCGTTAAGGCAATGCAAATCAAAACCACAATG (SEQ ID NO: 165) 
               
               
                   
               
               
                 160 
                 HGL6.354 
                   
                 AGCAACTTCAGCAAAGTCTCAGGATACAAAATCGATGTGCAAAAATCACAAGCA 
               
               
                   
                   
                   
                 TTCTTATACACCAACAACAGATAAACAGAGAGCC (SEQ ID NO: 166) 
               
               
                   
               
               
                 161 
                 HGL6.356 
                   
                 AACGGAAAAAAAACGGAATTATCGAATGGAATCGAAGAGAATCATCGAATGGA 
               
               
                   
                   
                   
                 CCAGAATGGAATCATCTAATGGAATGGAATGGAATAATCCATGGACTCGAATG 
               
               
                   
                   
                   
                 (SEQ ID NO: 167) 
               
               
                   
               
               
                 162 
                 HGL6.357 
                   
                 AACAGCAATAGACACAAAGTCAGCACTTACAGTACAAAAACTAATGGCAAAAGC 
               
               
                   
                   
                   
                 ACATGAAGTGGGACAT (SEQ ID NO: 168) 
               
               
                   
               
               
                 163 
                 HGL6.358 
                   
                 GGAATCAAACGGAATTATCGAATGGAATCGAAGAGAATCATAGAACGGACTCAA 
               
               
                   
                   
                   
                 ATGGAATCATCTAATGGAATGGAATGGGAGAATCCATGGACTCGAATG (SEQ ID 
               
               
                   
                   
                   
                 NO: 169) 
               
               
                   
               
               
                 164 
                 HGL6.360 
                 HGL6.1105 
                 AATGGAATCAATATCAAACGGAAAAAAACGGAATTATCGAATGGAATCGAAGA 
               
               
                   
                   
                   
                 GAATCATCGAATGGACC (SEQ ID NO: 170) 
               
               
                   
               
               
                 165 
                 HGL6.362 
                   
                 AAAATGATCATGAGAAAATTCAGCAACAAAACCATGAAATTGCAAAGATATTAC 
               
               
                   
                   
                   
                 TTTTGGGATGGAACAGAGCTGGAAGGCAAAGAG (SEQ ID NO: 171) 
               
               
                   
               
               
                 166 
                 HGL6.364 
                   
                 AACGGAATCAAACGGAATTATCGAATGGAATCGAAAAGAATCATCGAACGGACT 
               
               
                   
                   
                   
                 CGAATGGAATCATCTAATGGAATGGAATGGAAGAATCCATGG (SEQ ID NO: 172) 
               
               
                   
               
               
                 167 
                 HGL6.367 
                   
                 AAACGGAATTATCGAANGGAATCAAAGAGAATCATCGAANNNNNACGAATGGA 
               
               
                   
                   
                   
                 ATCATATAATGGAATGGAATGGAATAATCCATGGACC (SEQ ID NO: 173) 
               
               
                   
               
               
                 168 
                 HGL6.369 
                   
                 AATGGAATCGAATGGATTGATATCAAATGGAATGGAATGGAAGGGAATGGAATG 
               
               
                   
                   
                   
                 GAATGGAATTGAACCAAATGTAATGGATTTG (SEQ ID NO: 174) 
               
               
                   
               
               
                 169 
                 HGL6.371 
                   
                 TAAAAGACGGAACAGATAGAAAGCAGAAAGGAAAGGTGAATTGCATTACCACT 
               
               
                   
                   
                   
                 ATTCATACTGCCACACACATGACATTAGGCCAAGTC (SEQ ID NO: 175) 
               
               
                   
               
               
                 170 
                 HGL6.372 
                   
                 ACAAACAATCCAATTCGAAAATGGGCAAGATATTTCACCAAAGACATGAGCTGA 
               
               
                   
                   
                   
                 TATTTCAC (SEQ ID NO: 176) 
               
               
                   
               
               
                 171 
                 HGL6.373 
                   
                 AATGGAATCGAATGGAACAATCAAATGGACTCCAATGGAGTCATCTAATGGAAT 
               
               
                   
                   
                   
                 CGAGTGGAATCATCGAATGGACTCG (SEQ ID NO: 177) 
               
               
                   
               
               
                 172 
                 HGL6.374 
                   
                 TAACACATAAACAAACACAGAGACAAAATCTCCGAGATGTTAATCTGCTCCAGC 
               
               
                   
                   
                   
                 AATACAGAACAATTTCTATTACCAACAGAATGCTTAATTTTTCTGCCT (SEQ ID 
               
               
                   
                   
                   
                 NO: 178) 
               
               
                   
               
               
                 173 
                 HGL6.379 
                   
                 GGAATCGAATGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAA 
               
               
                   
                   
                   
                 TCAAAGAGAATCATCGAATGGACC (SEQ ID NO: 179) 
               
               
                   
               
               
                 174 
                 HGL6.382 
                   
                 AGAATGGAAAGGAATCGAAACGAAAGGAATGGAGACAGATGGAATGGAATG 
               
               
                   
                   
                   
                 (SEQ ID NO: 180) 
               
               
                   
               
               
                 175 
                 HGL6.383 
                   
                 GAATGGAATGGAAAGGAATCGAAACGAAAGGAATGGAGACAGATGGAATGGAA 
               
               
                   
                   
                   
                 TGGAACAGAGAGCAATGG (SEQ ID NO: 181) 
               
               
                   
               
               
                 176 
                 HGL6.387 
                   
                 GAATCATCATAAAATGGAATCGAATGGAATCAACATCAAATGGAATCAAATGGT 
               
               
                   
                   
                   
                 CTCGAATGGAATCATCTTCAAATGGAATGGAATGG (SEQ ID NO: 182) 
               
               
                   
               
               
                 177 
                 HGL6.389 
                   
                 AACAACAATGACAAACAAACAACAACGACAAAGACATTTATTTGGTTCACAAAT 
               
               
                   
                   
                   
                 CTCCAGGGTGTACAAGAAGCATGGTGCCAGCATCTGCTCAGCTTCTGATGAGGG 
               
               
                   
                   
                   
                 CTCTGGGAAGCTTTTACTC (SEQ ID NO: 183) 
               
               
                   
               
               
                 178 
                 HGL6.390 
                   
                 AACGGACTCGAACGGAATATAATGGAATGGAATGGATTCGAAAGGAATGGAAT 
               
               
                   
                   
                   
                 GGAATGGACAGGAAAAGAATTGAATGGGATTGGAATGGAATCG (SEQ ID NO: 
               
               
                   
                   
                   
                 184) 
               
               
                   
               
               
                 179 
                 HGL6.393 
                   
                 AGGAAATAAAAGAAGACACAAACAAATGGAAGAACATTCCATGCTTATGGATA 
               
               
                   
                   
                   
                 GGGAGAATCAGTATCGTGAAAATGGCCATACT (SEQ ID NO: 185) 
               
               
                   
               
               
                 180 
                 HGL6.394 
                 HGL6.1136 
                 AACATCAAACGAAATCAAACGGAATTATCAAATTGAATCGAAGAGAATCATCGA 
               
               
                   
                   
                   
                 ATTGCCACGAATGCAATCATCTAATGGTATGGAATGGAATAATCCATGGACCCA 
               
               
                   
                   
                   
                 GATG (SEQ ID NO: 186) 
               
               
                   
               
               
                 181 
                 HGL6.395 
                   
                 AGAAATTAACAGCAAAAGAAGGATGCAGTGCAACTCAGGACAACACATACAATT 
               
               
                   
                   
                   
                 CAAGCAACAAATGTATAGTGGCTGGGCACCAAGGATACAG (SEQ ID NO: 187) 
               
               
                   
               
               
                 182 
                 HGL6.396 
                   
                 GCAATAAAATCGACTCAGATAGAGAAGAATGCAATGGAATGGAATGGAATGGA 
               
               
                   
                   
                   
                 ATGGAATGGGATGGAATGGTATGGAATGG (SEQ ID NO: 188) 
               
               
                   
               
               
                 183 
                 HGL6.397 
                   
                 CCACATAAAACAAAACTACAAGACAATGATAAAGTTCACAACATTAACACAATC 
               
               
                   
                   
                   
                 AGTAATGGAAAAGCCTAGTCAATGGCAG (SEQ ID NO: 189) 
               
               
                   
               
               
                 184 
                 HGL6.399 
                   
                 GGACAACATACACAAATCAGTCAAGATACATCATTTCAACAGAATGAAAGACAA 
               
               
                   
                   
                   
                 AAACCATTTGATCACTTCAATCGATGATGAAAAAGCA (SEQ ID NO: 190) 
               
               
                   
               
               
                 185 
                 HGL6.400 
                   
                 GAAATCATCATCAAACGGAATCGAATGGAATCATTGAATGGAATGGAATGGAAT 
               
               
                   
                   
                   
                 CATCATGGAATGGAAACG (SEQ ID NO: 191) 
               
               
                   
               
               
                 186 
                 HGL6.405 
                   
                 TGGAATGGANTGGAATGNAATCNAATCNNNTGGTAATGAATCAAATGGAATCAA 
               
               
                   
                   
                   
                 ATCGAATGGNAATAATGGAATCNANNGGAAACGAATGGNATCGAATTGCACTGA 
               
               
                   
                   
                   
                 TTCTACTGACTTCGAGGAAAATGAAATGAAATGCGGTGAAGTGGAATGG (SEQ ID 
               
               
                   
                   
                   
                 NO: 192) 
               
               
                   
               
               
                 187 
                 HGL6.409 
                   
                 AGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGGGAAAAAATCACAAGCA 
               
               
                   
                   
                   
                 TTCCTATACATCAATAACAGACAAACAGAGAGCC (SEQ ID NO: 193) 
               
               
                   
               
               
                 188 
                 HGL6.410 
                   
                 GAATGTTATGAAATCAACTCGAACGGAATGCAATAGAATGGAATGGAATGGAAT 
               
               
                   
                   
                   
                 GGAATGGAATGGAATGG (SEQ ID NO: 194) 
               
               
                   
               
               
                 189 
                 HGL6.412 
                   
                 AGTAGAATTGCAATTGCAAATTTCACACATATACTCACACACAAGTACACACATC 
               
               
                   
                   
                   
                 CACTTTTACAACTAAAAAAACTAGCACCCAGGACAGGTGCAGTGGCT (SEQ ID 
               
               
                   
                   
                   
                 NO: 195) 
               
               
                   
               
               
                 190 
                 HGL6.416 
                   
                 GGAATCAACATCAAACGGAAAAAAAACGGAATTATCGAATGGAATCGAAGAGA 
               
               
                   
                   
                   
                 ATCATCGAATGGACC (SEQ ID NO: 196) 
               
               
                   
               
               
                 191 
                 HGL6.420 
                   
                 GGAATAATCATCATCAAACAGAACCAAATGGAATCATTGAATGGAATCAAAGGC 
               
               
                   
                   
                   
                 AATCATGGTCGAATG (SEQ ID NO: 197) 
               
               
                   
               
               
                 192 
                 HGL6.422 
                   
                 ACTCAGGAAAAATAACGAATCCAACTCACAGGAGAAAGAAGTACAAACCAGAA 
               
               
                   
                   
                   
                 ACCAATTTCAAATTACAAGGACCAGAATACTCATGTTGGCTGGCCAGT (SEQ ID 
               
               
                   
                   
                   
                 NO: 198) 
               
               
                   
               
               
                 193 
                 HGL6.424 
                   
                 AAACGCACAAACAAAGCAAGGAAAGAATGAAGCAACAAAAGCAGAGATTTATT 
               
               
                   
                   
                   
                 GAAAATGAAAAATACACTCCACAGGGTGGG (SEQ ID NO: 199) 
               
               
                   
               
               
                 194 
                 HGL6.429 
                   
                 GCATAGAATCGAATGGAATTATCATTGAATGGAATCGAATGGAATCAACATCAA 
               
               
                   
                   
                   
                 ACGGAAAAAAACGGAATTATCGAATGGAATCGAAGAGAATCATCGAATGGACC 
               
               
                   
                   
                   
                 C (SEQ ID NO: 200) 
               
               
                   
               
               
                 195 
                 HGL6.430 
                   
                 AATGGAATCGAANAGAATCATCGAACGGACTCGAATGGAATCATCTAATGGAAT 
               
               
                   
                   
                   
                 GGAATGGAATAATCCATGGACCCGAATG (SEQ ID NO: 201) 
               
               
                   
               
               
                 196 
                 HGL6.433 
                   
                 AAATGAATCGAATGGAATTGAATGGAATCAAATAGAACAAATGGAATCGAAATG 
               
               
                   
                   
                   
                 AATCAAATGGAATCGAATCGAATGGAATTGAATGGCATGGAATTG (SEQ ID NO: 
               
               
                   
                   
                   
                 202) 
               
               
                   
               
               
                 197 
                 HGL6.436 
                   
                 NTCACAATCACACAACACATTGCACATGNNNANNATGCACTCACAATACACACA 
               
               
                   
                   
                   
                 CAACACATACACAACACACATGCAATACAACACAAAACGCAACACAACATATAC 
               
               
                   
                   
                   
                 ACNACACACAGCACACANATGCC (SEQ ID NO: 203) 
               
               
                   
               
               
                 198 
                 HGL6.442 
                   
                 GAATGGAATCAAATCGAATGAAATGGAATGGAATAGAAAGGAATGGAATGAAA 
               
               
                   
                   
                   
                 TGGAATGGAAAGGATTCGAAT (SEQ ID NO: 204) 
               
               
                   
               
               
                 199 
                 HGL6.445 
                   
                 AAAGACTTAAACGTTAGACCTAAAACCATAAAAACCCTAGAGGAAAACCTAGGC 
               
               
                   
                   
                   
                 ATTACCATTCAGGACTTAGGCATGGGCAAGGAC (SEQ ID NO: 205) 
               
               
                   
               
               
                 200 
                 HGL6.446 
                   
                 GTTTACAGTCAAGTGTACAAACAGAATATAAGCAAACAAAAGAGAACATATACT 
               
               
                   
                   
                   
                 TACAAACTATGCTAAGTGCCATGAAGGAAAAG (SEQ ID NO: 206) 
               
               
                   
               
               
                 201 
                 HGL6.447 
                   
                 AAAGTCCAAAGATGAACAAAATATCCAGAAGGAAAACAAATGCACTTGGGGAG 
               
               
                   
                   
                   
                 TGGGAAAGAAAACCAAGACTGAGCAATGCGTCAAGCTCAGACGTGCCTCACTAC 
               
               
                   
                   
                   
                 G (SEQ ID NO: 207) 
               
               
                   
               
               
                 202 
                 HGL6.448 
                   
                 AAACGGAATCAAACGGAATTATCGAATGGAGTCGAAAAGAATCATCGAACGGA 
               
               
                   
                   
                   
                 CTCGAATGGAATCATCTAATGGAATGGAATGGAAGAATCCATGG (SEQ ID NO: 
               
               
                   
                   
                   
                 208) 
               
               
                   
               
               
                 203 
                 HGL6.450 
                 HGL6.1296 
                 AATTGATTCGAAATTAATGGAATTGAATGGAATGCAATCAAATGGAATGGAATG 
               
               
                   
                   
                   
                 TAATGCAATGGAATGTAATAGAATGGAAAGCAATGGAATG (SEQ ID NO: 209) 
               
               
                   
               
               
                 204 
                 HGL6.453 
                   
                 TACAGAACACATGACTCAACAACAGCAGAAAGCATATTCTTTTCAAATGCACAT 
               
               
                   
                   
                   
                 GAAACATTATCATGATGGACCAAAT (SEQ ID NO: 210) 
               
               
                   
               
               
                 205 
                 HGL6.454 
                   
                 TAAGACACATAGAAAACATAAAGCAAAATGGCAGATGTAAATGCAACCTATCAA 
               
               
                   
                   
                   
                 TCAAAACATTACGAATGGCTT (SEQ ID NO: 211) 
               
               
                   
               
               
                 206 
                 HGL6.456 
                   
                 GGAACAAAATGAAATCGAACGGTAGGAATCATACAGAACAGAAAGAAATGGAA 
               
               
                   
                   
                   
                 CGGAATGGAATG (SEQ ID NO: 212) 
               
               
                   
               
               
                 207 
                 HGL6.457 
                   
                 AACGGAAAAAACGGAATTATCGAATGGAATCGAAGAGAATCATCGAATGGAAT 
               
               
                   
                   
                   
                 CGAATGGAGTCATCG (SEQ ID NO: 213) 
               
               
                   
               
               
                 208 
                 HGL6.459 
                 HGL6.806 
                 AACATACGAAAATCAATAAACGTAATCCAGCATATAAACAGAACCAAAGACAA 
               
               
                   
                   
                   
                 AAACCACATGATTATCTCAATAGATGCAGAAAAGGCCTTT (SEQ ID NO: 214) 
               
               
                   
               
               
                 209 
                 HGL6.460 
                 HGL6.1163 
                 AATCGAACGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATC 
               
               
                   
                   
                   
                 GAAGAGAATCATCGAATGGACC (SEQ ID NO: 215) 
               
               
                   
               
               
                 210 
                 HGL6.461 
                   
                 AGAATGGAATGCAATAGAATGGAATGCAATGGAATGGAGTCATCCGTAATGGAA 
               
               
                   
                   
                   
                 TGGAAAGGAATGCAATGGAATGGAATGGAATGG (SEQ ID NO: 216) 
               
               
                   
               
               
                 211 
                 HGL6.462 
                   
                 GGAATAAAACGGACTCAATAGTAATGGATTGCAATGTAATTGATTCGATTTCGA 
               
               
                   
                   
                   
                 ATGGAATCGCATGGAATGTAATGGAATGGAATGGAATGGAAGGC (SEQ ID NO: 
               
               
                   
                   
                   
                 217) 
               
               
                   
               
               
                 212 
                 HGL6.467 
                   
                 AGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGTACAAAAATCACAAGCA 
               
               
                   
                   
                   
                 TTCTTATACACCAACAACAGACAAACAGAGAGCC (SEQ ID NO: 218) 
               
               
                   
               
               
                 213 
                 HGL6.476 
                   
                 TAAGCAGAGAAAATATCAACACGAAAATAATGCAAGGAGAAAAATACAGAACA 
               
               
                   
                   
                   
                 ATCCAAAATGTGGCC (SEQ ID NO: 219) 
               
               
                   
               
               
                 214 
                 HGL6.487 
                   
                 AATGGAATCAACATCAAACGGAAAAAAACGGAATTATCGTATGGAATCGAAAA 
               
               
                   
                   
                   
                 GAATTATCGAATGGACC (SEQ ID NO: 220) 
               
               
                   
               
               
                 215 
                 HGL6.489 
                 HGL6.587 
                 TCAAACGGAAAAAAACGGAATTATCGAATGGAATCGAAGAGAATCATCGAATG 
               
               
                   
                   
                   
                 GACC (SEQ ID NO: 221) 
               
               
                   
               
               
                 216 
                 HGL6.490 
                   
                 AACTTCAGCAAATTCTCAGGATACAAAATCAATGTGCAAAAACCACAAGCATTC 
               
               
                   
                   
                   
                 CTATACACCAATAATAGACAGTGAGCCAAAT (SEQ ID NO: 222) 
               
               
                   
               
               
                 217 
                 HGL6.494 
                 HGL6.1131 
                 ACATCAAACGGAATCAAACGGAATTATCGAATGGAATCGAAAAGAATCATCGAA 
               
               
                   
                   
                   
                 CGGACTCGAATGGAATCATCTAATGGAATGGAATGGAAGAATCCATGGACTCGA 
               
               
                   
                   
                   
                 ATG (SEQ ID NO: 223) 
               
               
                   
               
               
                 218 
                 HGL6.497 
                   
                 AATGGAATCGAATGCAATCATCGAACGGAATCGAATGGCATCACCGAATGGAAT 
               
               
                   
                   
                   
                 GGAATGGAATGGAATGGAATGG (SEQ ID NO: 224) 
               
               
                   
               
               
                 219 
                 HGL6.499 
                   
                 AATCCAGCATATAAACAGAACCAAAGACAAAAACCACATGATTATCTCAATAGA 
               
               
                   
                   
                   
                 TGCAGAAAAGGCC (SEQ ID NO: 225) 
               
               
                   
               
               
                 220 
                 HGL6.500 
                   
                 TGACTAAACAGAGTTGAACAAGAACAAAAAGCAAATTTGCAGAAATGAAATAC 
               
               
                   
                   
                   
                 ATACTAATTGAAAGTCCATGGACAGGCTCAACAGATGATATAGATACAGCTAAA 
               
               
                   
                   
                   
                 GAGATAATTAGTGAAATGGATCAG (SEQ ID NO: 226) 
               
               
                   
               
               
                 221 
                 HGL6.501 
                   
                 GATCATCAGAGAAACAGAGAAATGCAAATTAAAACCACAATGAGATACTATCTC 
               
               
                   
                   
                   
                 CACACAAGTCAGAATGGCTAT (SEQ ID NO: 227) 
               
               
                   
               
               
                 222 
                 HGL6.503 
                   
                 AGGATACAAAATCAATGTACAAAAATCACAAACATTCTTATACACCAACAACAG 
               
               
                   
                   
                   
                 ACAAACAGAGAGCCAAATCATGGGTG (SEQ ID NO: 228) 
               
               
                   
               
               
                 223 
                 HGL6.505 
                   
                 TAAGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGTACAAAAATCACAAG 
               
               
                   
                   
                   
                 CATTCTTATACACCAACAACAGACAAACAAGAGTGCCAAATCATG (SEQ ID NO: 
               
               
                   
                   
                   
                 229) 
               
               
                   
               
               
                 224 
                 HGL6.506 
                   
                 AGAATTGATTGAATCCAAGTGGAATTGAATGGAATGGAATGGATTAGAAAGGAA 
               
               
                   
                   
                   
                 TGGAATGGATTGGAATGGATTGGAATGGAAAGG (SEQ ID NO: 230) 
               
               
                   
               
               
                 225 
                 HGL6.508 
                   
                 AATGGAATGCAATCGAATGGAATGGAATCGAACGGAATGGAATAAAATGGAAG 
               
               
                   
                   
                   
                 AAAACTGGCAAGAAATGGAATCG (SEQ ID NO: 231) 
               
               
                   
               
               
                 226 
                 HGL6.509 
                   
                 AACTGCATCAACTAACAGGCAAAATAACCAGCTAATATCATAATGACAGGATTA 
               
               
                   
                   
                   
                 AATTCACAAATGACAATATTAACCGTAAATGTAAATGGGCTA (SEQ ID NO: 232) 
               
               
                   
               
               
                 227 
                 HGL6.510 
                   
                 TACAAAGAACTCAAACAAATCAGCAAGAACAAAAACAATCCCAACAAAATGTTG 
               
               
                   
                   
                   
                 GACAAAGACATGAATAGACAATTCTCGAAAGAAGATGTACAAATGGCT (SEQ ID 
               
               
                   
                   
                   
                 NO: 233) 
               
               
                   
               
               
                 228 
                 HGL6.512 
                   
                 AGAGAAATGCAAATCAAAACCACAATGGAATACCATCTCACGCCAGTCAGAATG 
               
               
                   
                   
                   
                 GCAATTATTAAAAAATCACAACAATTAATGATGGCAAGGCTGTGG (SEQ ID NO:  
               
               
                   
                   
                   
                 234) 
               
               
                   
               
               
                 229 
                 HGL6.513 
                   
                 GTAAACAAACAATCAAGCAAGTAAGAACAGAAATAACAGCATTTGGCTTTTGAG 
               
               
                   
                   
                   
                 TTAATGACAAGAACACTCGGCATGGGAGCCTGGGTGAGCAAATCACAGATCTTC 
               
               
                   
                   
                   
                 (SEQ ID NO: 235) 
               
               
                   
               
               
                 230 
                 HGL6.514 
                   
                 GAATCAACCCGAGCGGAAAGGAATGGAATGGAATGGAATCAACACGAATGGAA 
               
               
                   
                   
                   
                 TGGAACGGAATGGAATGGGATGGGATGAAATGGAATGG (SEQ ID NO: 236) 
               
               
                   
               
               
                 231 
                 HGL6.516 
                   
                 AGCAACTTCAGCAAAGTCTCAGGAGACAAAATCAATGTACAAAAATCACAAGCA 
               
               
                   
                   
                   
                 TTCTTATACACCAATAACAGACAAACAGAGAGCC (SEQ ID NO: 237) 
               
               
                   
               
               
                 232 
                 HGL6.520 
                   
                 AAGAAATGGAATCGAAGAGAATGGAAACAAACGGAATGGAATTGAATGGAATG 
               
               
                   
                   
                   
                 GAATTGAATGGAATGGGA (SEQ ID NO: 238) 
               
               
                   
               
               
                 233 
                 HGL6.522 
                   
                 GACATGCAAACACAACACACAGCACACATGGAACATGCATCAGACATGCAAACA 
               
               
                   
                   
                   
                 CAACACACATACCACACATGGCATATGCATCAGACGTGCCTCACTAC (SEQ ID 
               
               
                   
                   
                   
                 NO: 239) 
               
               
                   
               
               
                 234 
                 HGL6.528 
                   
                 TACAGATAAGAAAATTGAGACTCAAGAGTATTACATAAATTGTTTCAGCTACCAC 
               
               
                   
                   
                   
                 AGCAAAAAATGGTATGGTTGGGAATCAAGCTCAGGG (SEQ ID NO: 240) 
               
               
                   
               
               
                 235 
                 HGL6.529 
                   
                 AAAGGAATGCACTCGAATGGAATGGACTTGAATGGAATGTCTCCGAATGGAACA 
               
               
                   
                   
                   
                 GACTCGTATGAAATGGAATCGAATGGAATGGAATCAAATGGAATTGATTTGAGT 
               
               
                   
                   
                   
                 GAAATGGAATCAAATGGAATGGCAACG (SEQ ID NO: 241) 
               
               
                   
               
               
                 236 
                 HGL6.530 
                   
                 TGAAACAAATGATAATGAAAATACAACATACCAAACATACGAGATACAGTAAAA 
               
               
                   
                   
                   
                 GCAGTACTAAGATGCAAGTATATATTGCTACAAGTGCCTAC (SEQ ID NO: 242) 
               
               
                   
               
               
                 237 
                 HGL6.531 
                   
                 GGAACAAAATGAAATCGAACGGTAGGAATCGTACAGAACGGAAAGAAATGGAA 
               
               
                   
                   
                   
                 CGGAATGGAATGCACTCGAATGGAAAGGAGTCCAAT (SEQ ID NO: 243) 
               
               
                   
               
               
                 238 
                 HGL6.532 
                   
                 AAATTGATTGAAATCATCATAAAATGGAATCGAAGGGAATCAACATCAAATGGA 
               
               
                   
                   
                   
                 ATCAAATGGAATCATTGAACGGAATTGAATGGAATCGTCAT (SEQ ID NO: 244) 
               
               
                   
               
               
                 239 
                 HGL6.533 
                   
                 AGAAAGGATTCGAATGGAATGAAAAAGAATTGAATGGAATAGAACAGAATGGA 
               
               
                   
                   
                   
                 ATCAAATCGAATGAAATGGAATGGAATAGAAAGGAATGGAATG (SEQ ID NO: 
               
               
                   
                   
                   
                 245) 
               
               
                   
               
               
                 240 
                 HGL6.534 
                   
                 AGAATGGAAAGCAATAGAATGGAACGCACTGGATTCGAGTGCAATGGAATCAAT 
               
               
                   
                   
                   
                 TGGAATGGAATCGAATGGAATGGATTGGCA (SEQ ID NO: 246) 
               
               
                   
               
               
                 241 
                 HGL6.535 
                   
                 AACACCAAACGGAAAAAAACGGAATTATCGAATGGAATCGAAGAGAATCTTCG 
               
               
                   
                   
                   
                 AACGGACCCGAATGGGATCATCTAATGGAATGGAATGGAATAATCCATGG (SEQ 
               
               
                   
                   
                   
                 ID NO: 247) 
               
               
                   
               
               
                 242 
                 HGL6.536 
                   
                 AATGGAGACTAATGTAATAGAATCAAATGGAATGGCATCGAATGGAATGGACTG 
               
               
                   
                   
                   
                 GAATGGAATGTGCATGAATGGAATGGAATCGAATGGATTG (SEQ ID NO: 248) 
               
               
                   
               
               
                 243 
                 HGL6.539 
                   
                 TGGGATATGGGTGAAAGAACAAGTTTGCAGAAAAGATACAGTGAATTATGGACC 
               
               
                   
                   
                   
                 ATGAGTTCGGGAAAGAAGGGTAGGACTGCG (SEQ ID NO: 249) 
               
               
                   
               
               
                 244 
                 HGL6.540 
                   
                 AAATCGAATGGAACGCAATAGAATAGACTCGAATGTAATGGATTGCTATGTAAT 
               
               
                   
                   
                   
                 TGATTCGAATGGAATGGAATCGACTGGAATGCAATCCAATGGAATGGAATGCAA 
               
               
                   
                   
                   
                 TGCAATGGAATGGAATCGAACGGAATGCAGTGGAAGGGAATGG (SEQ ID NO:  
               
               
                   
                   
                   
                 250) 
               
               
                   
               
               
                 245 
                 HGL6.541 
                   
                 AATCAACAAGGAACTGAAACAAGTAAACAAGAAAACAAATAACACCATAAAAC 
               
               
                   
                   
                   
                 ATGGGCAAAGGACATAAACAGACATTTTTCAAAAAAGACATACAAATGGCCGAG 
               
               
                   
                   
                   
                 (SEQ ID NO: 251) 
               
               
                   
               
               
                 246 
                 HGL6.542 
                   
                 AATGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATCGAAGA 
               
               
                   
                   
                   
                 GAATCATCGAATGGACCCAGGCTGGTCTTGAACTCC (SEQ ID NO: 252) 
               
               
                   
               
               
                 247 
                 HGL6.545 
                   
                 ATTGAATGGGCTAGAATGGAATCATCTTTGAACGGAATCAAAGGGAATCATCAT 
               
               
                   
                   
                   
                 CGAATGGAATCGAATGGAAATGTCAACG (SEQ ID NO: 253) 
               
               
                   
               
               
                 248 
                 HGL6.547 
                   
                 AATGGACTCGAATGGAATCAACATCAAATGGAATCAAGCGGAATTATCGAATGA 
               
               
                   
                   
                   
                 AATCGAAGAGAATCATCGAATGGACTCGAAAGGAATCATCTAATGGAATGGAAT 
               
               
                   
                   
                   
                 GGAATAATCCATGGACTCGAATGCAATCATCATCG (SEQ ID NO: 254) 
               
               
                   
               
               
                 249 
                 HGL6.549 
                   
                 ACAGACAGAGATTTAAAACAATAAACAAGCAGTAAGCAAACACAGATAACAAA 
               
               
                   
                   
                   
                 ATGACATGATCCAACAAATACTCAGAAGGAGACTTAGAAATGAATTGAGGGTC 
               
               
                   
                   
                   
                 (SEQ ID NO: 255) 
               
               
                   
               
               
                 250 
                 HGL6.553 
                   
                 AATGTAATCCAGCATATAAACAGAGCCAAAGACAAAAACCACATGATTATCTCA 
               
               
                   
                   
                   
                 ATAGATGCAGAAAAAGCCTTTGACAAAATTCAACAACCCTTCATGCTAAAAACT 
               
               
                   
                   
                   
                 CTCAATAAATTAGGTATTGATGGGACG (SEQ ID NO: 256) 
               
               
                   
               
               
                 251 
                 HGL6.555 
                   
                 AAACGGAAAAAAACGGAATTATTGAATGGAATCGAAGAGAATCTTCGAACGGA 
               
               
                   
                   
                   
                 CCCGAATGGAATCATCTAATGGAATGGAATGGAATAATCCATGG (SEQ ID NO:  
               
               
                   
                   
                   
                 257) 
               
               
                   
               
               
                 252 
                 HGL6.557 
                 HGL6.1238 
                 GCTCAAGGAAATAAAATAGGACACAAAGAAATGGAAAAACATTCCATACTCATG 
               
               
                   
                   
                   
                 GATAGAAAGAATCAATATCATGAAATGGCC (SEQ ID NO: 258) 
               
               
                   
               
               
                 253 
                 HGL6.560 
                   
                 ACTCGAGTGGAATTGACTGTAACAAAATGGAAAGTAACGGATTGGAATCGAATG 
               
               
                   
                   
                   
                 GAACGGAATGGAATGGAATGGACAT (SEQ ID NO: 259) 
               
               
                   
               
               
                 254 
                 HGL6.561 
                   
                 TACAAACTTTAAAAAATGATCAACAGATACACAGTTAGCAAGAAAGAATTGAGG 
               
               
                   
                   
                   
                 GCAAAGAATATGCCAGACAAACTCAAGAGGAAGATGATGGTAGAGATAGGTCA 
               
               
                   
                   
                   
                 CATTGGAGTGTCA (SEQ ID NO: 260) 
               
               
                   
               
               
                 255 
                 HGL6.562 
                 HGL6.154, 
                 GGAATCGAATGGAATCAATATCAAACGGAAAAAAACGGAATTATCGAATGGAAT 
               
               
                   
                   
                 HGL6.114 
                 CGAAGAGAATCATCGAATGGACC (SEQ ID NO: 261) 
               
               
                   
               
               
                 256 
                 HGL6.564 
                   
                 AACGGAATCAAACGGAATTATCGAATGGAATCGAAAAGAATCATCGAACGGACT 
               
               
                   
                   
                   
                 CGAATGGAATCATCTAATGTAATGGAATGGAAGAATCCATGGACTCGAATG 
               
               
                   
                   
                   
                 (SEQ ID NO: 262) 
               
               
                   
               
               
                 257 
                 HGL6.565 
                   
                 GGAAATAACAGAGAACACAAACAAATGGGAAAACATTCCATGTTCATGGATAGG 
               
               
                   
                   
                   
                 AAGAATCAATATTGTGAAAATGGCCATACT (SEQ ID NO: 263) 
               
               
                   
               
               
                 258 
                 HGL6.570 
                   
                 AACGGAAAAAAACGGAATTATCGAATGGAATCGAAGAGAATCATCGAATGGAC 
               
               
                   
                   
                   
                 CAGAATGGAATCATCTAATGGAATGGAATGGAATAATCCATGGACTCGAATG 
               
               
                   
                   
                   
                 (SEQ ID NO: 264) 
               
               
                   
               
               
                 259 
                 HGL6.581 
                   
                 CAACATCAAACGGAAAAAAACGGAATTATGGAATGGAATCGAAGAGAATCATC 
               
               
                   
                   
                   
                 GAATGGACCCGAATGGAATCATCTGAAATATAATAGACTCGAAAGGAATG (SEQ 
               
               
                   
                   
                   
                 ID NO: 265) 
               
               
                   
               
               
                 260 
                 HGL6.589 
                   
                 ATGGAATCGAATGGAATGGACTGGAATGGAATGGATTCGAATGGAATCGAATGG 
               
               
                   
                   
                   
                 AACAATATGGAATGGTACCAAATG (SEQ ID NO: 266) 
               
               
                   
               
               
                 261 
                 HGL6.595 
                 HGL6.1293 
                 GAATGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATCGAAG 
               
               
                   
                   
                   
                 AGAATCATCGAATGGACC (SEQ ID NO: 267) 
               
               
                   
               
               
                 262 
                 HGL6.606 
                   
                 AAGGAATTTAAGCAAATCAACAAGCAAAACCAAAATAATCCCATTAAAAAGTGG 
               
               
                   
                   
                   
                 GTAAAGGACATGAATACACACTTGTCAATAGAGGACATTCAAGTGGCCAAC 
               
               
                   
                   
                   
                 (SEQ ID NO: 268) 
               
               
                   
               
               
                 263 
                 HGL6.608 
                   
                 AAATGGACTCGAATGGAATCATCATAGAATGGAATCGAATGCAATGGAATGGAA 
               
               
                   
                   
                   
                 TCTTCCGGAATGGAATGGAATGGAATGGAATGGAG (SEQ ID NO: 269) 
               
               
                   
               
               
                 264 
                 HGL6.609 
                   
                 GAATCANCNNNNNNNGGAATCGAATGGAATCAACATCAAATGGAATCAAATGG 
               
               
                   
                   
                   
                 AATCATTGAACGGAATTGAATGGAATCGTCAT (SEQ ID NO: 270) 
               
               
                   
               
               
                 265 
                 HGL6.610 
                   
                 AGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGTACAAAAATCACAAGCA 
               
               
                   
                   
                   
                 TTCTTATACACCAATAACAGACAAACAGAGAGCCAAAA (SEQ ID NO: 271) 
               
               
                   
               
               
                 266 
                 HGL6.611 
                   
                 TATGCAAATCAATAAACATAATCCATCACATAAACAGAAACAAAGACAAAATGA 
               
               
                   
                   
                   
                 CATGATTATCTCAATAGATGCAGAAAAGGCC (SEQ ID NO: 272) 
               
               
                   
               
               
                 267 
                 HGL6.615 
                   
                 AGTAAATCACCATAAAGAAGGTAAGAGTTCATTCACAAAAACAACAAACTGAAG 
               
               
                   
                   
                   
                 AATCAGGCCATAGTA (SEQ ID NO: 273) 
               
               
                   
               
               
                 268 
                 HGL6.617 
                   
                 AGAAACAGAAAACAGTCAAACCAATGGGCAATCCATATCAGATGCAGTATTATG 
               
               
                   
                   
                   
                 AACAGAAGTGTAAAGAATGCACCAGGCACAATGGC (SEQ ID NO: 274) 
               
               
                   
               
               
                 269 
                 HGL6.619 
                   
                 AGGAAAAACAACAACAACAACAGGAAAACAACCTCAGTATGAAGACAAGTACA 
               
               
                   
                   
                   
                 TTGATTTATTCAACATTTACTGATCACTTTTCAGGTGGTAGGCAG (SEQ ID NO: 
               
               
                   
                   
                   
                 275) 
               
               
                   
               
               
                 270 
                 HGL6.623 
                   
                 GATTGGAACGAAATCGAATGGAACGGAATAGAATAGACTCGAATGTAATGGATT 
               
               
                   
                   
                   
                 GCTATGTAATTGATTCGAATGGAATGGAATCGAATGGAATGCAATCCAATGGAA 
               
               
                   
                   
                   
                 TGGAATGCAATGCAATGGAATGG (SEQ ID NO: 276) 
               
               
                   
               
               
                 271 
                 HGL6.624 
                   
                 AACATATGGAAAAAAACTCAACATCACTGATCATTAGAGAAATGCAAATCAAAA 
               
               
                   
                   
                   
                 CCACAATGAGATACCATCTCACGCCAGTCAGAATGGCG (SEQ ID NO: 277) 
               
               
                   
               
               
                 272 
                 HGL6.625 
                   
                 ATGGAATGGAATAATCAACGTACTCGAATGCAATCATCATCGTATAGAATCGAA 
               
               
                   
                   
                   
                 TGGAATCATCGAATGGACTCGAATGGAATAATCATTGAACGGAGTCGAATGGAA 
               
               
                   
                   
                   
                 TCATCATCGGATGGAAAC (SEQ ID NO: 278) 
               
               
                   
               
               
                 273 
                 HGL6.627 
                   
                 AAANAANTCNAATGGAATCNNTGNCGAATGGAATGGAATGGAATCGAANAATT 
               
               
                   
                   
                   
                 GAATTGNNNANAATCNNANGNAANCNTTGNATGGGCTCAAAT (SEQ ID NO: 279) 
               
               
                   
               
               
                 274 
                 HGL6.629 
                   
                 AGAAAAGATAACTCGATTAACAAATGAACAAACACCTGAATACACAAGTCTCAA 
               
               
                   
                   
                   
                 AAGAAGACATAAAAATGGCCAAC (SEQ ID NO: 280) 
               
               
                   
               
               
                 275 
                 HGL6.632 
                   
                 ATGGAATCAACATCAAACGGAATCACACGGAATTATCGAATGGAATCGAAAAGA 
               
               
                   
                   
                   
                 ATCATCGAACGGACTCGAATGGAATCATCTAATGGAATGGAATGGAAG (SEQ ID 
               
               
                   
                   
                   
                 NO: 281) 
               
               
                   
               
               
                 276 
                 HGL6.633 
                 HGL6.1135 
                 AATGGAATCAACATCAAACGGAATCAAGCGAAATTATCGAATGGAATCGAAGAG 
               
               
                   
                   
                   
                 AATCATCGAATGGACTCGAATGGAATCATCTAATGGAATGGAATGGGAT (SEQ ID 
               
               
                   
                   
                   
                 NO: 282) 
               
               
                   
               
               
                 277 
                 HGL6.634 
                   
                 AAACACAGTACAAATACTAATTCAAATCAAACTTACTCAAAGTCATAATCAAAC 
               
               
                   
                   
                   
                 ATGCCAGACGGGCTGAGGGGCAGCATTA (SEQ ID NO: 283) 
               
               
                   
               
               
                 278 
                 HGL6.638 
                   
                 AACCACTGCTCAAGGAAATAAGAGAGAACACAAACAAATGAAAAAACATTCCA 
               
               
                   
                   
                   
                 TGCTCATGGATAGGAAGAATCAG (SEQ ID NO: 284) 
               
               
                   
               
               
                 279 
                 HGL6.641 
                   
                 GGAATCGAGTGGAATCATCGAAAGAAATCGAATGGAATCATTGTCGAATGGAAT 
               
               
                   
                   
                   
                 GGAATGGAATCAAAGAATGGAATCGAAGGGAATCATTGGATGGGCT (SEQ ID 
               
               
                   
                   
                   
                 NO: 285) 
               
               
                   
               
               
                 280 
                 HGL6.642 
                   
                 AAAGAAAGACAGAGAACAAACGTAATTCAAGATGACTGTTTACATATCCAAGAA 
               
               
                   
                   
                   
                 CATTAGATGGTCAAAGACTTTAAGAAGGAATACATTCAAAGGCAAAAAGTCACT 
               
               
                   
                   
                   
                 TACTGATTTTGGTGGAGTTTGCCACATGGAC (SEQ ID NO: 286) 
               
               
                   
               
               
                 281 
                 HGL6.645 
                   
                 AAGATAGAGTTGAAACAGTGGACAATTAAAGAGTAATTTGGAAGAATGGTGAAA 
               
               
                   
                   
                   
                 TTACAGCCATGCTTTGAATCAGGCGGGTTCACTGGC (SEQ ID NO: 287) 
               
               
                   
               
               
                 282 
                 HGL6.646 
                   
                 AAGAGTATCAACAGTAAATTACATTAGCAGAAGAATCAACAAACATGAAAATAG 
               
               
                   
                   
                   
                 AAATTATGGTAGCCAAAGAACAG (SEQ ID NO: 288) 
               
               
                   
               
               
                 283 
                 HGL6.647 
                   
                 GAAAGGAATCATCATTGAATGCAATCACATGGAATCATCACAGAATGGAATCGT 
               
               
                   
                   
                   
                 ACGGAATCATCATCGAATGGAATTGAATGGAATCATCAATTGGACTCGAATGGA 
               
               
                   
                   
                   
                 ATCATCAAATGGAATCGATTGGAAGTGTCAAATGGACTCG (SEQ ID NO: 289) 
               
               
                   
               
               
                 284 
                 HGL6.651 
                   
                 CAGCGCACCACAGCACACACAGTATACACATGACCCACAATACACACAACACAC 
               
               
                   
                   
                   
                 AACACATTCACACACCAC (SEQ ID NO: 290) 
               
               
                   
               
               
                 285 
                 HGL6.655 
                   
                 GCAAACAGAATTCAACACTACATTAGAACGATCATTCATCACGACCTAGTAGGA 
               
               
                   
                   
                   
                 TGTTTTTCCTGGGATGCAAGGATGGTTCAACAT (SEQ ID NO: 291) 
               
               
                   
               
               
                 286 
                 HGL6.656 
                   
                 CAATCAAAACAGCAATGAGATACCATTTTACACCAATCAAAATGGCTACTAAAA 
               
               
                   
                   
                   
                 AGTCAAAAGCAAATGCC (SEQ ID NO: 292) 
               
               
                   
               
               
                 287 
                 HGL6.658 
                 HGL6.830 
                 AGAACCATATTGAAGAGACAGAGTGATATATAAAACTGCTAACTCAAGCAGCAC 
               
               
                   
                   
                   
                 AAGAATTAAATGAATACCAAGAAAATACTTGGCCAG (SEQ ID NO: 293) 
               
               
                   
               
               
                 288 
                 HGL6.660 
                   
                 TGGAATAGAATGGAATCAATGTTAAGTGGAATCGAGTGGAATCATCGAAAGAAA 
               
               
                   
                   
                   
                 TCGAATGGAATCATTGTCGAATGGTATGGAATGGAATCA (SEQ ID NO: 294) 
               
               
                   
               
               
                 289 
                 HGL6.661 
                   
                 AATGGAATGGAATCATCGCATAGAATNGAATGGAATTATCATCGAATTGAATCG 
               
               
                   
                   
                   
                 AATGGTATCAACATCAAACGGAAAAAAACGGAAATATCGAANGGAATCGAAGA 
               
               
                   
                   
                   
                 GAATCATCGAACGGACC (SEQ ID NO: 295) 
               
               
                   
               
               
                 290 
                 HGL6.662 
                   
                 ACATACGCAAATCAATAAACATAATCCATCACATAAACAGAACCAAAGACAAAA 
               
               
                   
                   
                   
                 ATCACATGATTATCTCAATAGATGCAGAAAAGGCCTTCGAC (SEQ ID NO: 296) 
               
               
                   
               
               
                 291 
                 HGL6.663 
                   
                 AAAAAATGTTCAACATCACTAGTCAGCAGAGAAATGCAAATCAAAATCACAATG 
               
               
                   
                   
                   
                 AGATAACTTCTCACACCAGACAGCATGGC (SEQ ID NO: 297) 
               
               
                   
               
               
                 292 
                 HGL6.668 
                   
                 GAAAAACAAAACAAAACAAACAAACAAACAATCAAAAAAGTGGTAGCAGAAAC 
               
               
                   
                   
                   
                 CAGAAAGTCCATGTATATAGCTAATTGGCCTGGTTGT (SEQ ID NO: 298) 
               
               
                   
               
               
                 293 
                 HGL6.671 
                   
                 AACAGCAATGACAATGATCAGTAACAACAAGACTTTTAACTTTGAAAAAATCAG 
               
               
                   
                   
                   
                 GACC (SEQ ID NO: 299) 
               
               
                   
               
               
                 294 
                 HGL6.672 
                   
                 AAGAGCCTGAATAGCTAAAGTGATCATAAGCAAAAAGAACAAAGTCGGAAGCA 
               
               
                   
                   
                   
                 TCACATTACCTGACTTCAAACTATACTCAAAGGCTATG (SEQ ID NO: 300) 
               
               
                   
               
               
                 295 
                 HGL6.675 
                   
                 AAAAGGAAATACAAGACAACAAACACAGAAACACAACCATCGGGCATCATGAA 
               
               
                   
                   
                   
                 ACCTCGTGAAGATAATCATCAGGGT (SEQ ID NO: 301) 
               
               
                   
               
               
                 296 
                 HGL6.677 
                   
                 AAGCAAAGAAAGAATGAAGCAGCAAAAGAACGAAAGCAGGAATTTATTGAAAA 
               
               
                   
                   
                   
                 CCAAAGTACACTCCACAGTATGGGAGCGGACCCGAGCA (SEQ ID NO: 302) 
               
               
                   
               
               
                 297 
                 HGL6.679 
                   
                 GCAAATGATTATAAGTGCTGTTATAGAAACATTCAAAGACCAGAAAAGGACCAC 
               
               
                   
                   
                   
                 AATGGCTGACCAC (SEQ ID NO: 303) 
               
               
                   
               
               
                 298 
                 HGL6.681 
                   
                 AGAGCAGAAACAAATGGAATTGAAATGAAGACAACAATCAAAAGCATCAATGA 
               
               
                   
                   
                   
                 AATGAAAAGTTGGGTTTTGGAAGAGAGAAACAAT (SEQ ID NO: 304) 
               
               
                   
               
               
                 299 
                 HGL6.683 
                   
                 ACACAAACACACACACACACACACACACACACACACACACACACACACACACAC 
               
               
                   
                   
                   
                 ACACACACACACATAC (SEQ ID NO: 305) 
               
               
                   
               
               
                 300 
                 HGL6.686 
                   
                 AACAAACAAATGAGATGATTTCAGATAGTGATAAACACTATAACATAATTAATT 
               
               
                   
                   
                   
                 CGTGCCAATCAGAGCATAACAGTGGTGTGGTGGCTGTGGAACAGATAGCAGAC 
               
               
                   
                   
                   
                 (SEQ ID NO: 306) 
               
               
                   
               
               
                 301 
                 HGL6.688 
                   
                 AATGGAATCGAGTGGAATGGAAGGCAATGGAATAGAATGGAATGGAATCGAAA 
               
               
                   
                   
                   
                 GGAACGGAATGGAATGGAATGGAATG (SEQ ID NO: 307) 
               
               
                   
               
               
                 302 
                 HGL6.689 
                   
                 AGCAGTGCAAGAACAACATAACATACAAGTAAACAAACACATGGGGCCAGGTA 
               
               
                   
                   
                   
                 ATAAAAAGTCAGGCTCAAGAGGTCAG (SEQ ID NO: 308) 
               
               
                   
               
               
                 303 
                 HGL6.690 
                   
                 AGAAATGGAATCGGAGAGAATGGAAACAAATGGAATGGAATTGAATGGAATGG 
               
               
                   
                   
                   
                 AATTGAATGGAATGGGAACG (SEQ ID NO: 309) 
               
               
                   
               
               
                 304 
                 HGL6.694 
                   
                 GCACTAGTCAGATCAAGACAGAAAGTCAACGAACAAAGAACAGACTTAAACTAC 
               
               
                   
                   
                   
                 ACTCTAGAACAAATGGACCTA (SEQ ID NO: 310) 
               
               
                   
               
               
                 305 
                 HGL6.704 
                   
                 AAGAGAACTGCAAAACACTGCTCAAAGAAATCAGAGATGACAAAAACACATGG 
               
               
                   
                   
                   
                 AAAAACGTTTCATGCTCATGGATTGGAAGACTTA (SEQ ID NO: 311) 
               
               
                   
               
               
                 306 
                 HGL6.705 
                   
                 AATCAACACGAATAGAATGGAACGGAATGGAATGGAATGGAATGGAATGGAAT 
               
               
                   
                   
                   
                 GGAGTGGAATGGAACAGAATGGAGTGGAAT (SEQ ID NO: 312) 
               
               
                   
               
               
                 307 
                 HGL6.707 
                   
                 AACATCAAACGAAATCAAACGGAATTATCAAATTGAATCGAAGAGAATCATCGA 
               
               
                   
                   
                   
                 ATTGCCACGAATGCAACCATCTAATGGTATGGAATGGAATAATCCATGGACCCA 
               
               
                   
                   
                   
                 GATG (SEQ ID NO: 313) 
               
               
                   
               
               
                 308 
                 HGL6.714 
                   
                 CGGAATTATCATCGAATGTAATCGAATGGAATCAACATCAAACGGAAAAAAACG 
               
               
                   
                   
                   
                 GAATTATCGAATGGAATCGAAGAGAATCATCGAATGGACC (SEQ ID NO: 314) 
               
               
                   
               
               
                 309 
                 HGL6.719 
                   
                 TGGACACACACGAACACACACCTACACACACGTGGACACACACGGACACATGGA 
               
               
                   
                   
                   
                 CACACACGAACACATGGACACACACACGGGGACACACACAGACACACACAGAG 
               
               
                   
                   
                   
                 ACACACACGGACACATGG (SEQ ID NO: 315) 
               
               
                   
               
               
                 310 
                 HGL6.720 
                 HGL6.1044 
                 AGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGTGCAAAAATCACAAGCA 
               
               
                   
                   
                   
                 TTCTTATACACCAATAACAGACAAACAGAGAGCC (SEQ ID NO: 316) 
               
               
                   
               
               
                 311 
                 HGL6.721 
                 HGL6.1020 
                 AAAATCAATATGAAAACAAACACAAGCAGACAAAGAAAATTGGGCAAAAGGTT 
               
               
                   
                   
                   
                 TGAGCAGACACTTCACCAAAGAAGTACAAATGGCAAATCAGCA (SEQ ID NO: 
               
               
                   
                   
                   
                 317) 
               
               
                   
               
               
                 312 
                 HGL6.724 
                   
                 ATCAAACGGAATCAAACGGAATTATCGAATGGAATCGAAGAGAATCATCGAATG 
               
               
                   
                   
                   
                 GACTCGAATGGAATCATCTAATGGAATGGAATGGAAGAATCCATGG (SEQ ID NO: 
               
               
                   
                   
                   
                 318) 
               
               
                   
               
               
                 313 
                 HGL6.725 
                   
                 AACAGATTTAAACAAACCAACAAGCAAAAAACGAACAACTCCATTCAAACATGG 
               
               
                   
                   
                   
                 ACAAAAGACACGAACAGACACTTTTCAAAGAAGACATACATGTGGCC (SEQ ID 
               
               
                   
                   
                   
                 NO: 319) 
               
               
                   
               
               
                 314 
                 HGL6.726 
                   
                 AAATGGAATGGAATGCACTTGAAAGGAATAGACTGGAACAAAATGAAATCGAA 
               
               
                   
                   
                   
                 CGGTAGGAATCATACAGAACAGAAAGAAATGGAACGGAATGGAATG (SEQ ID 
               
               
                   
                   
                   
                 NO: 320) 
               
               
                   
               
               
                 315 
                 HGL6.727 
                   
                 ACCACACACAAAATACACCACACACCACACACACACCACACACTATACACACAC 
               
               
                   
                   
                   
                 CACACACCACACAC (SEQ ID NO: 321) 
               
               
                   
               
               
                 316 
                 HGL6.728 
                   
                 AAAGAAATAGAAGGGAGTTGAACAGAATCGAATGGAATCGAATCAAATGGAAT 
               
               
                   
                   
                   
                 CGAATGGCATCAAATGGAATCGAATGGAATGTGGTGAAGTGGATTGG (SEQ ID 
               
               
                   
                   
                   
                 NO: 322) 
               
               
                   
               
               
                 317 
                 HGL6.729 
                   
                 GGAATCATCATAAAATGGAATCGAATGGAATCATCATCAAATGGAATCAAATGG 
               
               
                   
                   
                   
                 AATCATTGAACGGAATTGAATGGAATCGTCAT (SEQ ID NO: 323) 
               
               
                   
               
               
                 318 
                 HGL6.730 
                   
                 TGGAATGGAATGGAATGAAATAAACACGAATAGAATGGAACGGAATGGAACGG 
               
               
                   
                   
                   
                 AATGGAATGGAATGGAATGGAAAG (SEQ ID NO: 324) 
               
               
                   
               
               
                 319 
                 HGL6.731 
                   
                 AAGAATTGGACAAAACACACAAACAAAGCAAGGAAGGAATGAAAGGATTTGTT 
               
               
                   
                   
                   
                 GAAAATGAAAGTACACTCCACAGTGTGGGAGCAG (SEQ ID NO: 325) 
               
               
                   
               
               
                 320 
                 HGL6.732 
                   
                 TAATCAGCACAATCAACTGTAGTCACAAAACAAATAGTAACGCAATGATAAAGA 
               
               
                   
                   
                   
                 AACAGAGAACTAGTTCAAATAAACATGATAAGATGGGG (SEQ ID NO: 326) 
               
               
                   
               
               
                 321 
                 HGL6.733 
                   
                 AAGCGGAATTATCAAATGGAATCGAAGAGAATGGAAACAAATGGAATGGAATT 
               
               
                   
                   
                   
                 GAATGGAATGGAATTGAATGGAATG (SEQ ID NO: 327) 
               
               
                   
               
               
                 322 
                 HGL6.734 
                   
                 AAGCAACTTCAGCAAAGTCTCAGGACACAAAATCAATATGCGAAAATCACAAGC 
               
               
                   
                   
                   
                 ATTCCTATACACCAATAATAGACAAACAGAGAGCCAAATCATG (SEQ ID NO: 328) 
               
               
                   
               
               
                 323 
                 HGL6.736 
                   
                 TTCACAGCAGCATTACGCACAATAGCCAGAAGGTGGGAACAGACAAAATGCCTT 
               
               
                   
                   
                   
                 TTGATGGG (SEQ ID NO: 329) 
               
               
                   
               
               
                 324 
                 HGL6.738 
                   
                 AGACCCTAATATCACAGTTAAACGAACTAGAGAAGGAAGAGCAAACAAATTCAA 
               
               
                   
                   
                   
                 AAGCTAGCGGAAAGCAAGAAATAACTAAGACCAG (SEQ ID NO: 330) 
               
               
                   
               
               
                 325 
                 HGL6.739 
                   
                 TAAAAGTGTGCTCAACATCATTGATCATCAGAGAAATGCAAATCAAAACTACAA 
               
               
                   
                   
                   
                 TGAGATATCATCTCATCCCAGTCAAAGTGGCT (SEQ ID NO: 331) 
               
               
                   
               
               
                 326 
                 HGL6.740 
                   
                 ACTTGAATCGAATGGAAAGGAATTTAATGAACTTAAATCGAATGGAATATAATG 
               
               
                   
                   
                   
                 GTATGGAATGGACTCATGGAATGGAATGGAAAGGAATC (SEQ ID NO: 332) 
               
               
                   
               
               
                 327 
                 HGL6.742 
                   
                 TGGAATCATCATCGAAAGCAAGCGAATGGAATCATCAAATGGAAACGAATGGAA 
               
               
                   
                   
                   
                 TCATCGAATGGACTCGGATGGAATTGTTGAATGGACT (SEQ ID NO: 333) 
               
               
                   
               
               
                 328 
                 HGL6.743 
                   
                 TGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATCGAAGAGA 
               
               
                   
                   
                   
                 ATCATCGAATGGACC (SEQ ID NO: 334) 
               
               
                   
               
               
                 329 
                 HGL6.745 
                   
                 TAAGTGAATTGAATAGAATCAATCTGAATGTAATGAAATGGAATGGAACGGAAT 
               
               
                   
                   
                   
                 GGAATGGAATGGAATGGAATGGAATGGAATGG (SEQ ID NO: 335) 
               
               
                   
               
               
                 330 
                 HGL6.747 
                   
                 AGGAAAATTTAATCAGCAGGAATAGAAACACACTTGAGAAATCCATGTGGAATG 
               
               
                   
                   
                   
                 AAAAGAGAATGGCTGAGCAGCAACAGATTGTCAAAAAGGAAATC (SEQ ID NO: 
               
               
                   
                   
                   
                 336) 
               
               
                   
               
               
                 331 
                 HGL6.749 
                 HGL6.897 
                 AACATCAAACGGAAAAAAAACGGAATTATCGAATGGAATCGAAGAGAATCATC 
               
               
                   
                   
                   
                 GAATGGACC (SEQ ID NO: 337) 
               
               
                   
               
               
                 332 
                 HGL6.756 
                   
                 GAAAATGAACAATATGAACAAACAAACAAAATTACTACCCTTACGAAAGTACGT 
               
               
                   
                   
                   
                 GCATTCTAGTATGGTGACAAAAAGGAAA (SEQ ID NO: 338) 
               
               
                   
               
               
                 333 
                 HGL6.757 
                   
                 AGAAAACACACAGACAACAAAAAACACAGAACGACAATGACAAAATGGCCAAG 
               
               
                   
                   
                   
                 C (SEQ ID NO: 339) 
               
               
                   
               
               
                 334 
                 HGL6.758 
                 HGL6.1040 
                 AGCAACTTCAGCAAAGACTCAGGATACAAAATCAATGTGCAAAAATCACAAGCA 
               
               
                   
                   
                   
                 TTCTTATACACCAATAACAGACAGAGAGCCAAAT (SEQ ID NO: 340) 
               
               
                   
               
               
                 335 
                 HGL6.759 
                   
                 TGACATGCAAGAAATAAGGAAGTGCAAAAACAAACAAACAAACAACAACAACA 
               
               
                   
                   
                   
                 ACAACAACAACAACAACAAAAAACAGTCCCAAAAGGATGGGCAG (SEQ ID NO: 
               
               
                   
                   
                   
                 341) 
               
               
                   
               
               
                 336 
                 HGL6.760 
                   
                 TAATTGAGAATAAGCATTCCAGTGGAAAAAAAACTAAACAATTTGTTGTAAAAC 
               
               
                   
                   
                   
                 ATCCTTAAAAGCATCAGAAAGTTAATACAGCAATGAAGAATTACAGGACCAAAT 
               
               
                   
                   
                   
                 TAAGAATGGTATGGAAGCCTGTTA (SEQ ID NO: 342) 
               
               
                   
               
               
                 337 
                 HGL6.762 
                   
                 TATCATCGAATGGAATCGAATGGAATCAACATCAAACGGAAAAAAACGGAATTA 
               
               
                   
                   
                   
                 TCGAATTGAATCGAAGAGAATCATCGAATGGACC (SEQ ID NO: 343) 
               
               
                   
               
               
                 338 
                 HGL6.764 
                   
                 GAATGGAATCAAATAGAATGGAATCGAAACAAATGGAATGGAATGGAATGGGA 
               
               
                   
                   
                   
                 GCTGAGATTGTGTCACTGCAC (SEQ ID NO: 344) 
               
               
                   
               
               
                 339 
                 HGL6.765 
                   
                 AGCAAAACAAACACAATCTGTCGTTCATGGTACTACGACATACTGGGAGAGATA 
               
               
                   
                   
                   
                 TTCAAATGATCACACAAAACAACATG (SEQ ID NO: 345) 
               
               
                   
               
               
                 340 
                 HGL6.766 
                   
                 AAGGATTCGAATGGAATGAAAAAGAATTGAATGGAATAGAACAGAATGGAATC 
               
               
                   
                   
                   
                 AAATCGAATGAAATGGAGTGGAATAGAAAGGAATGGAATG (SEQ ID NO: 346) 
               
               
                   
               
               
                 341 
                 HGL6.768 
                   
                 AACGGAATCAAACGGAATTATCGAATGNNNTNNAAGAGAATCATCGAACGGACT 
               
               
                   
                   
                   
                 CGAATGGAATCATCTAATGGAATGGAATGGAAGAATCCATGGACTCGAATGCAA 
               
               
                   
                   
                   
                 TCATCATCGAATGGAATCGAACGGAATCATCGAATGGCC (SEQ ID NO: 347) 
               
               
                   
               
               
                 342 
                 HGL6.771 
                   
                 AATCAACTAGATGTCAATGGAATGCAATGGAATAGAATGGAATGGAATTAACAC 
               
               
                   
                   
                   
                 GAATAGAATGGAATGGAATGGAATGGAATGG (SEQ ID NO: 348) 
               
               
                   
               
               
                 343 
                 HGL6.772 
                   
                 TGTAACACTGCAAACCATAAAAACCGTAGAAGAAAACCTAGACAATACTATTCA 
               
               
                   
                   
                   
                 GGACATAGGCATGGGCAAAGAC (SEQ ID NO: 349) 
               
               
                   
               
               
                 344 
                 HGL6.773 
                   
                 AATGGACTCGAATGGAATAATCATTGAACGGAATCGAATGGAATCATCATCGGA 
               
               
                   
                   
                   
                 TGGAAATGAATGGAATCATCATCGCATGGAATCG (SEQ ID NO: 350) 
               
               
                   
               
               
                 345 
                 HGL6.776 
                   
                 GAATGGAATGATACGGAATAGAATGGAATGGAACGAAATGGAATTGAAAGGAA 
               
               
                   
                   
                   
                 AGGAATGGAATGGAATGGAATGG (SEQ ID NO: 351) 
               
               
                   
               
               
                 346 
                 HGL6.777 
                   
                 AAAAATGACCAGAGCAATAGAATGCATTGACCAGATAAAGACCTTCACGTATGT 
               
               
                   
                   
                   
                 TGAACTAAAATGTGTGGTGCAGGTG (SEQ ID NO: 352) 
               
               
                   
               
               
                 347 
                 HGL6.781 
                   
                 AATCATCATCGAATGGAATCGAATGGTATCATTGANTGNAATCGAATGGAATCA 
               
               
                   
                   
                   
                 TCATCANATGGAAATGAATGGAATCGTCAT (SEQ ID NO: 353) 
               
               
                   
               
               
                 348 
                 HGL6.785 
                   
                 ACAAAATCAAACTAACCTCGATAAGAATGCAAGTGAATCAAAATGAGTTTCAAG 
               
               
                   
                   
                   
                 GGGTTGTGGCTAGTACACGCTTTCTACAGCTG (SEQ ID NO: 354) 
               
               
                   
               
               
                 349 
                 HGL6.787 
                   
                 GAATCAAATCAATGGAATCAAATCAAATGGAATGGAATGGAATTGTATGGAATG 
               
               
                   
                   
                   
                 GAATGGCATGG (SEQ ID NO: 355) 
               
               
                   
               
               
                 350 
                 HGL6.789 
                   
                 TAATGCAGTCCAATAGAATGGAATCGAATGGCATGGAATATAAAGAAATGGAAT 
               
               
                   
                   
                   
                 CGAAGAGAATGGGAACAAATGGAATGGAATTGAGTGGAATGGAATTGAATGGA 
               
               
                   
                   
                   
                 ATGGGAACGAATGGAGTG (SEQ ID NO: 356) 
               
               
                   
               
               
                 351 
                 HGL6.792 
                   
                 TGAATAGACACACAGACCAATGGAACAGAATAGAGAACACAGAATAAATCTGC 
               
               
                   
                   
                   
                 ACACTTATAGCCAGCTGATTTTTGACAAATTTGCCAAG (SEQ ID NO: 357) 
               
               
                   
               
               
                 352 
                 HGL6.797 
                 HGL6.810, 
                 AACATCNNACGGAAAAAAACGGAATTATCGAATGGAATCGAAGAGAATCATCG 
               
               
                   
                   
                 HGL6.1172, 
                 AATGGACC (SEQ ID NO: 358) 
               
               
                   
                   
                 HGL6.1223 
                   
               
               
                   
               
               
                 353 
                 HGL6.801 
                   
                 GCCAACAATCATATGAGAAAAAGCTCAACATCACTGATCATTTCAGGAATGCAA 
               
               
                   
                   
                   
                 ATCAAAACCACAATGAGATACTATCACACATCAATCAGAATGGCT (SEQ ID NO: 
               
               
                   
                   
                   
                 359) 
               
               
                   
               
               
                 354 
                 HGL6.802 
                 HGL6.118, 
                 GAATCGAATGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATC 
               
               
                   
                   
                 HGL6.590, 
                 GAAGAGAATCATCGAATGGACC (SEQ ID NO: 360) 
               
               
                   
                   
                 HGL6.1051, 
                   
               
               
                   
                   
                 HGL6.1170, 
                   
               
               
                   
                   
                 HGL6.1248, 
                   
               
               
                   
                   
                 HGL6.1372 
                   
               
               
                   
               
               
                 355 
                 HGL6.804 
                   
                 AATCAAATGGAATGAAATCGAATGGAATTGAATCGAATGGAATGCAATAGAATG 
               
               
                   
                   
                   
                 TCTTCAAATGGAATCGAATGGAAATTGGTGAAGTGGACGGGAGTG (SEQ ID NO: 
               
               
                   
                   
                   
                 361) 
               
               
                   
               
               
                 356 
                 HGL6.805 
                   
                 TAACAGTACCAAAAAACAGTCATAATCTTCAAGAGCTTAAATTTAGCATGAAAG 
               
               
                   
                   
                   
                 GAAGACATTCATCAAAGAATCACACAAAGGAATGTAAAATTAAATGGAGATTAG 
               
               
                   
                   
                   
                 TGCCAGGAAAGAGC (SEQ ID NO: 362) 
               
               
                   
               
               
                 357 
                 HGL6.808 
                   
                 TAATGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGCAATCGAAGA 
               
               
                   
                   
                   
                 GAATCATCGAATGGACC (SEQ ID NO: 363) 
               
               
                   
               
               
                 358 
                 HGL6.813 
                   
                 AGCAACTTCAGCAAAGTCTCAGCATACAAAATCAATGTGCAAAAATCACACGCA 
               
               
                   
                   
                   
                 TTCCTATACACCAATAACAGACAAACAGAGAGCC (SEQ ID NO: 364) 
               
               
                   
               
               
                 359 
                 HGL6.815 
                   
                 GAATCAAATGGAATGGACTGTAATGGAATGGATTCGAATGGAATCGAATGGAGT 
               
               
                   
                   
                   
                 GGACTCAAATGGAATG (SEQ ID NO: 365) 
               
               
                   
               
               
                 360 
                 HGL6.816 
                   
                 AACAAGTGGACGAAGGATATGAACAGACACTTCTCAAGACATTTATGCAGCCAA 
               
               
                   
                   
                   
                 CAGACACACGAAAAAATGCTCATCATCACTGGCCATCAG (SEQ ID NO: 366) 
               
               
                   
               
               
                 361 
                 HGL6.819 
                   
                 AAACACACAAAGCAACAAAAGAACGAAGCAACAAAAGCATAGATTTATTGAAA 
               
               
                   
                   
                   
                 TGAAAGTACATTCTACAGAGTGGGGGCAGGCT (SEQ ID NO: 367) 
               
               
                   
               
               
                 362 
                 HGL6.820 
                   
                 ATACAACTAAAGCAAATATAAGCAACTAAAGCAACAGTACAACTAAAGCAAAA 
               
               
                   
                   
                   
                 CAGAACAAGACTGCCAGGGCCTAGAAAAGCCAAGAAC (SEQ ID NO: 368) 
               
               
                   
               
               
                 363 
                 HGL6.822 
                   
                 GCAATCGAATGGAATGGAATCGAACGGAATGGAATAAAATGGAAGAAAACTGG 
               
               
                   
                   
                   
                 CAAGAAATGGAATCG (SEQ ID NO: 369) 
               
               
                   
               
               
                 364 
                 HGL6.825 
                   
                 AGCAGCCAACAAGCATATGAAATAATGCTCCACAACACTCATCATCAGAGAAAT 
               
               
                   
                   
                   
                 GCAAATCAAAACCAAAAT (SEQ ID NO: 370) 
               
               
                   
               
               
                 365 
                 HGL6.826 
                   
                 TGGAACCGAACAAAGTCATCACCGAATGGAATTGAAATGAATCATAATCGAATG 
               
               
                   
                   
                   
                 GAATCAAATGGCATCTTCGAATTGACTCGAATGCAATCATCCACTGGGCTT (SEQ 
               
               
                   
                   
                   
                 ID NO: 371) 
               
               
                   
               
               
                 366 
                 HGL6.827 
                 HGL6.829 
                 AACGGAATCACGCGGAATTATCGAATGGAATCGAAGAGAATCATCGAATGGACT 
               
               
                   
                   
                   
                 CGAATGGAATCATCTAATGGAATGGAATGG (SEQ ID NO: 372) 
               
               
                   
               
               
                 367 
                 HGL6.830 
                   
                 AGAACCATATTGAAGAGACAGAGTGATATATAAAACTGCTAACTCAAGCAGCACAAGAATTA 
               
               
                   
                   
                   
                 AATGAATACCAAGAAAATACTTGGCCAG (SEQ ID NO: 373) 
               
               
                   
               
               
                 368 
                 HGL6.831 
                   
                 AAAACAAACAACAACGACAAATCATGAGACCAGAGTTAAGAAACAATGAGACC 
               
               
                   
                   
                   
                 AGGCTGGGTGTGGTG (SEQ ID NO: 374) 
               
               
                   
               
               
                 369 
                 HGL6.833 
                   
                 AATCGAAAGGAATGCAATATTATTGAACAGAATCGAAAAGAATGGAATCAAATG 
               
               
                   
                   
                   
                 GAATGGAACAGAGTGGAATGGACTGC (SEQ ID NO: 375) 
               
               
                   
               
               
                 370 
                 HGL6.836 
                   
                 AAGGAATCGAATGGAAGTGAATGAAATTGAATCAACAGGAATGGAAGGGAATA 
               
               
                   
                   
                   
                 GAATAGACTGTAATGGAATGGACTCG (SEQ ID NO: 376) 
               
               
                   
               
               
                 371 
                 HGL6.837 
                   
                 AATGGACTCGAATGAAATCATCATCAAACGGAATCGAATGGAATCATTGAATGG 
               
               
                   
                   
                   
                 AATGGAATGGAATCATCATGGAATGGAAACG (SEQ ID NO: 377) 
               
               
                   
               
               
                 372 
                 HGL6.838 
                   
                 TTGACCAGAACACATTACACAATGCTAATCAACTGCAAAGGAGAATATGAACAG 
               
               
                   
                   
                   
                 AGAGGAGGACATGGATATTTTGTG (SEQ ID NO: 378) 
               
               
                   
               
               
                 373 
                 HGL6.839 
                   
                 AACCCGAGTGCAATAGAATGGAATCGAATGGAATGGAATGGAATGGAATGGAA 
               
               
                   
                   
                   
                 TGGAATGGAGTC (SEQ ID NO: 379) 
               
               
                   
               
               
                 374 
                 HGL6.843 
                   
                 AAGAGTATTGAAGTTGACATATCTAGACTGATCAAGAACAAAGACAAAAGGTAC 
               
               
                   
                   
                   
                 AGATTATCAAGAAAATGAGCGGGCAAAGCAAGATGGCC (SEQ ID NO: 380) 
               
               
                   
               
               
                 375 
                 HGL6.847 
                   
                 GAATGGAATTGAAAGGAATGGAATGCAATGGAATGGAATGGGATGGAATGGAA 
               
               
                   
                   
                   
                 TGCAATGGAATCAACTCGATTGCAATG (SEQ ID NO: 381) 
               
               
                   
               
               
                 376 
                 HGL6.849 
                   
                 GAAAAAAACGGAATTATCNAATTGAATCNAATANAATCATCNNNNNGACCANA 
               
               
                   
                   
                   
                 NTGGAATCATCTAATGNAATGNAATGGAATAATCCATGGACTCNAATG (SEQ ID 
               
               
                   
                   
                   
                 NO: 382) 
               
               
                   
               
               
                 377 
                 HGL6.850 
                   
                 GAAAAAAACGGAATTATCGAATTGAATCGAATAGAATCATCGAACGGACCAGAA 
               
               
                   
                   
                   
                 TGGAATCATCTAATGGAATGGAATGGAATAATCCATGGACTCGAATG (SEQ ID 
               
               
                   
                   
                   
                 NO: 383) 
               
               
                   
               
               
                 378 
                 HGL6.853 
                   
                 AACCACTGCTTAAGGAAATAAGAGAGAACACAAACAAATGGAAAAACGTTCCAT 
               
               
                   
                   
                   
                 GCTCATGGATAGGAGAATCAATATCGTGAAAATGGCC (SEQ ID NO: 384) 
               
               
                   
               
               
                 379 
                 HGL6.854 
                   
                 TATCGAATGGAATGGAAAGGAGTGGAGTAGACTCGAATAGAATGGACTGGAATG 
               
               
                   
                   
                   
                 AAATAGATTCGAATGGAATGGAATGGAATGAAGTGGACTCG (SEQ ID NO: 385) 
               
               
                   
               
               
                 380 
                 HGL6.855 
                   
                 GTATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATCATCTAATGGA 
               
               
                   
                   
                   
                 ATGGAATGGAATAATCCATGGACTCGAATG (SEQ ID NO: 386) 
               
               
                   
               
               
                 381 
                 HGL6.856 
                   
                 TAAATGGAGACATCATTGAATACAATTGAATGGAATCATCACATGGAATCGAAT 
               
               
                   
                   
                   
                 GGAATCATCGTAAATGCAATCAAGTGGAATCAT (SEQ ID NO: 387) 
               
               
                   
               
               
                 382 
                 HGL6.857 
                   
                 GAATGGAATTGAAAGGTATCAACACCAAACGGAAAAAAAAACGGAATTATCGA 
               
               
                   
                   
                   
                 ATGGAATCGAAGAGAATCATCGAACGGACC (SEQ ID NO: 388) 
               
               
                   
               
               
                 383 
                 HGL6.858 
                   
                 AGCAATTTCAGCAAAGTCTCAGGATACAAAATCAATGTACAAATTCACAAGCAT 
               
               
                   
                   
                   
                 TCTTATGGACCAACAACAG (SEQ ID NO: 389) 
               
               
                   
               
               
                 384 
                 HGL6.860 
                   
                 AACCAAATTAGACAAATTGGAAATCATTACACATAACAAAAGTAATAAACTGTC 
               
               
                   
                   
                   
                 AGCCTCAGTAGTATTCATTGTACATAAACTGGCC (SEQ ID NO: 390) 
               
               
                   
               
               
                 385 
                 HGL6.861 
                   
                 TATTTTACCAGATTATTCAAGCAATATATAGACAGCTTAAAGCATACAAGAAGAC 
               
               
                   
                   
                   
                 ATGTATAGATTTACATGCAAACACTGCACCACTTTACATAAGGGACTTGAGCAC 
               
               
                   
                   
                   
                 (SEQ ID NO: 391) 
               
               
                   
               
               
                 386 
                 HGL6.863 
                   
                 GGAATCGAATGGCATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAAT 
               
               
                   
                   
                   
                 CGAATGGAATCATC (SEQ ID NO: 392) 
               
               
                   
               
               
                 387 
                 HGL6.864 
                   
                 AAACAAAACACAGAAATGCAAAGACAAAACATAAAACGCAGCCATAAAGGACA 
               
               
                   
                   
                   
                 TATTTTAGATAACTGGGGAAATTTGTATGGGCTGTGT (SEQ ID NO: 393) 
               
               
                   
               
               
                 388 
                 HGL6.866 
                 HGL6.867 
                 AGGAAAAGAAAGAAATAGAAAATGCGAAATGGTAAGAAAAAACAGCATAATAA 
               
               
                   
                   
                   
                 ACATTTGTATGGTGTTGATGGACAATGCATT (SEQ ID NO: 394) 
               
               
                   
               
               
                 389 
                 HGL6.869 
                   
                 AATGGAATCAACATCAAACGGAATCAAACGGAATTATCGAATGGAATCGAAGAG 
               
               
                   
                   
                   
                 AATCATCGAACGGACTCGAATGGAATCATCTAATGGAATGGAATGGAAG (SEQ 
               
               
                   
                   
                   
                 ID NO: 395) 
               
               
                   
               
               
                 390 
                 HGL6.872 
                 HGL6.1072, 
                 AATCGAATGGAATCAGCATCAAACGGAAAAAAACGGAATTATCGAATGGAATCG 
               
               
                   
                   
                 HGL6.1301 
                 AAGAGAATCATCGAATGGACC (SEQ ID NO: 396) 
               
               
                   
               
               
                 391 
                 HGL6.877 
                   
                 AAAGAAATGGAATCGAAGAGAATGGAAACAAATGGAATGGAATTGAATGGAAT 
               
               
                   
                   
                   
                 GGAATTGAATGGAATGGGAACG (SEQ ID NO: 397) 
               
               
                   
               
               
                 392 
                 HGL6.878 
                   
                 AGAAAGAATCAAGAGGAAATGCAAGAAATCCAAAACACTGTAACAGATATGAT 
               
               
                   
                   
                   
                 GAATAATGAGGTATGCACTCATCAGCAGACTCGACAT (SEQ ID NO: 398) 
               
               
                   
               
               
                 393 
                 HGL6.879 
                   
                 AAACGGAATTATNNANTGGANNNNAAGNNAATCATCGAACGGANNNNANNGGA 
               
               
                   
                   
                   
                 ATCATNTNNNNGAANGGAATGGAACAATCCATGGTNTNNNN (SEQ ID NO: 399) 
               
               
                   
               
               
                 394 
                 HGL6.882 
                 HGL6.971 
                 AGCAACTTCAGCAAAGTTTCAGGATACAAAATCAATGTGCAAAAATCACAAGCA 
               
               
                   
                   
                   
                 TTCTTATACACCAACAACAGACAAACAGAGAGCC (SEQ ID NO: 400) 
               
               
                   
               
               
                 395 
                 HGL6.884 
                   
                 AGACAGTCAGACAATCACAAAGAAACAAGAATGAAAATGAATGAACAAAACCT 
               
               
                   
                   
                   
                 TCAAGAAATATGGGATTATGAAGAGGCCAAATGT (SEQ ID NO: 401) 
               
               
                   
               
               
                 396 
                 HGL6.885 
                   
                 ATCATAACGACANGANCAAATTCACACACAACAATNNNNACNNNAAANNCAAA 
               
               
                   
                   
                   
                 TGGGTTAAATNNTNCAATTAAAGGATGCAGACGGGCAAATTGGATA (SEQ ID NO: 
               
               
                   
                   
                   
                 402) 
               
               
                   
               
               
                 397 
                 HGL6.891 
                   
                 ATCATAANGACAAGANCAAATTCACACACAACAATNNNNACNNNAAANNCAAA 
               
               
                   
                   
                   
                 TGGGTTNAATGNTNCAATTAAAGGATGCAGACGGNCAAATTGGATA (SEQ ID NO: 
               
               
                   
                   
                   
                 403) 
               
               
                   
               
               
                 398 
                 HGL6.895 
                   
                 GAATGGAATCGAATGGATTGATATCAACTGGAATGGAATGGAAGGGAATGGAAT 
               
               
                   
                   
                   
                 GGAATGGAATTGAACCAAATGTNNNNGNCTTGAATGGAATG (SEQ ID NO: 404) 
               
               
                   
               
               
                 399 
                 HGL6.898 
                   
                 GAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATCGAAGAGAAT 
               
               
                   
                   
                   
                 CATCGAATGGACC (SEQ ID NO: 405) 
               
               
                   
               
               
                 400 
                 HGL6.904 
                   
                 ATGGAATCAACATCAAACGGAATCAAACGGAATTATCGAATGGAATCAAAGAGA 
               
               
                   
                   
                   
                 ATCATCGAACGGACTCGAATGGAATCATCTAATGGAATGGAATGGAAGAATCCA 
               
               
                   
                   
                   
                 TGGACTCGAATGCAATCATCATCGAAT (SEQ ID NO: 406) 
               
               
                   
               
               
                 401 
                 HGL6.905 
                   
                 GGAATGGAATGGAATGGAGCNGAATNGAANGGANNNNANTCAAATGGAATGC 
               
               
                   
                   
                   
                 (SEQ ID NO: 407) 
               
               
                   
               
               
                 402 
                 HGL6.906 
                   
                 AACATACGC   AAATCAATAAATG   TAATCCAGCATATAAACAGAACCAAAGACAA 
               
               
                   
                   
                   
                 AAACCACATGATTATCTCAATAGATGCAGAAAAGGCC (SEQ ID NO: 408) 
               
               
                   
               
               
                 403 
                 HGL6.911 
                   
                 AAACGATTGGACAGGAATGGAATCACCATCGAATGGAAACGAATGGAATCTTCG 
               
               
                   
                   
                   
                 AATGGAATTGAATGAAATTATTGAACGGAATCAAATAGAATCATCATTGAACAG 
               
               
                   
                   
                   
                 AATCAAATTGGATCAT (SEQ ID NO: 409) 
               
               
                   
               
               
                 404 
                 HGL6.912 
                   
                 AAAAGATGCAAAAGTAGCAAATGCAATGTTAAAACAAGCAAAGAAAGAATCAG 
               
               
                   
                   
                   
                 GTGGACCACATAGTGCAGTGCTTCTC (SEQ ID NO: 410) 
               
               
                   
               
               
                 405 
                 HGL6.914 
                   
                 AACAATAAACAAACTCCAACTAGACACAATAGTCAAATTGCTGAAAATGAAATA 
               
               
                   
                   
                   
                 TAAAGGAACAATCTCGATGGTAGCCCAAGGA (SEQ ID NO: 411) 
               
               
                   
               
               
                 406 
                 HGL6.915 
                 HGL6.916 
                 AGTCAATAACAAGAAGACAAACAACCCAATTACAAAATGGGATATGAATTTAAT 
               
               
                   
                   
                   
                 AGATGTTACTCCAAGGAAGATACACAAATGGCCAAC (SEQ ID NO: 412) 
               
               
                   
               
               
                 407 
                 HGL6.919 
                   
                 AAAACACCTAGGAATACAGATAACAAGGGACATTAACTACCTCTTAAAGAGAAC 
               
               
                   
                   
                   
                 TACAAACCACTGCTCAAGGAAATGAGAGAGGACACAAACACATGGAAAAACAT 
               
               
                   
                   
                   
                 TCCATCCTCATGGATAGGAAGAATCAATATTGTGAAAATGGCC (SEQ ID NO: 413) 
               
               
                   
               
               
                 408 
                 HGL6.921 
                   
                 GATATATAAACAAGAAAACAACTAATCACAACTCAATATCAAAGTGCAATGATG 
               
               
                   
                   
                   
                 GTGCAAAATGCAAGTATGGTGGGGACAGAGAAAGGATGC (SEQ ID NO: 414) 
               
               
                   
               
               
                 409 
                 HGL6.923 
                   
                 ACACATATCAAACAAACAAAAGCAATTGACTATCTAGAAATGTCTGGGAAATGG 
               
               
                   
                   
                   
                 CAAGATATTACA (SEQ ID NO: 415) 
               
               
                   
               
               
                 410 
                 HGL6.924 
                   
                 GGAATCATCATATAATGGAATCGAATGGAATCAACATCAAATGGAATCAAATGG 
               
               
                   
                   
                   
                 AATCATTGAACGGAATTGAATGGAATCGTCAT (SEQ ID NO: 416) 
               
               
                   
               
               
                 411 
                 HGL6.926 
                   
                 CCCAACTTCAAATTATACTACAAGGCTACAGTAATCAAAAAAGCATAGTACTATT 
               
               
                   
                   
                   
                 ACAAAAACAGACACACAGGCCAATGGAATACAAT (SEQ ID NO: 417) 
               
               
                   
               
               
                 412 
                 HGL6.927 
                   
                 AAACGCAGAAACAAATCAACGAAAGAACGAAGCAATGAAAGACAAAGCAACAA 
               
               
                   
                   
                   
                 AAGAATGGAGTAAGAAAGCACACTCCACAAAGTGGAAGCAGGCTGGGACA (SEQ 
               
               
                   
                   
                   
                 ID NO: 418) 
               
               
                   
               
               
                 413 
                 HGL6.928 
                   
                 AACTAACACAAGAACAGAAAACCAAACATCACATGTTCTCACTCATAAGCGGGA 
               
               
                   
                   
                   
                 GCTGAACAATGAGAACACACGGACACAGGGAGAGGAACATG (SEQ ID NO: 419) 
               
               
                   
               
               
                 414 
                 HGL6.929 
                   
                 GCCACAATTTTGAAACAACCATAATAATGAGAATACACAAGACAACTCCAATAA 
               
               
                   
                   
                   
                 TGTGGGAAGACAAACTTTGCAATTCACATCATGGC (SEQ ID NO: 420) 
               
               
                   
               
               
                 415 
                 HGL6.933 
                   
                 AATGGAATCAACATCAAACGGAATCAAATGGAATTATCGAATGGAATCGAAGAG 
               
               
                   
                   
                   
                 AATCATCGAATTGTCACGAATGGAATCATCTAATGGAATGGAATGGAATAATCC 
               
               
                   
                   
                   
                 ATGGCCCCTATGC (SEQ ID NO: 421) 
               
               
                   
               
               
                 416 
                 HGL6.934 
                 HGL6.935 
                 TAAACAGAACCAAAGACAAAAATCACATGATTATCTCAATAGATGCAGAAAAGG 
               
               
                   
                   
                   
                 CC (SEQ ID NO: 422) 
               
               
                   
               
               
                 417 
                 HGL6.937 
                   
                 ATCAACAGACAACAGAAACAAATCCACAAAGCACTTAGTTATTAGAACTGTCAT 
               
               
                   
                   
                   
                 ACAGACTGTACAACAACCACATTTACCAT (SEQ ID NO: 423) 
               
               
                   
               
               
                 418 
                 HGL6.938 
                   
                 AATGGACTCGAATGAAATCATCATCAAACAGAATCGAATGGAATCATCTAATGG 
               
               
                   
                   
                   
                 AATGGAATGGCATAATCCATGGACTCGAATG (SEQ ID NO: 424) 
               
               
                   
               
               
                 419 
                 HGL6.939 
                   
                 TAAAATGAAACAAATATACAACACGAAGGTTATCACCAGAAATATGCCAAAACT 
               
               
                   
                   
                   
                 TAAATATGAGAATAAGACAGTCTCAGGGGCCACAGAG (SEQ ID NO: 425) 
               
               
                   
               
               
                 420 
                 HGL6.940 
                   
                 AAAATACAGCGTTATGAAAAGAATGAACACACACACACACACACACACACAGA 
               
               
                   
                   
                   
                 AAATGT (SEQ ID NO: 426) 
               
               
                   
               
               
                 421 
                 HGL6.942 
                   
                 TACTCTCAGAAGGGAAGCAGATATTCAGCATAAATCATATTGTTTGTACAAAGA 
               
               
                   
                   
                   
                 GTCTGGGCATGGTGAATGACACT (SEQ ID NO: 427) 
               
               
                   
               
               
                 422 
                 HGL6.943 
                   
                 CAAACAAATAGGTACCAAACAAATAACAACATAAACCTGACAACACACTTATTT 
               
               
                   
                   
                   
                 ACAAGAGACATCCCTTATATGAAAGGGTACAGAAAAGTCGATGGTAAGATGATG 
               
               
                   
                   
                   
                 GGGAAAGGTATACCAACCACTAGCAGAAGG (SEQ ID NO: 428) 
               
               
                   
               
               
                 423 
                 HGL6.944 
                   
                 TGGAATCGAATGGAATCAATATCAAACGGAAAAAAACGGAATTATCGAATGGAA 
               
               
                   
                   
                   
                 TCGAAAAGAATCATCGAATGGGCCCGAATGGAATCATCT (SEQ ID NO: 429) 
               
               
                   
               
               
                 424 
                 HGL6.945 
                   
                 ACAAATGGAATCAACAACGAATGGAATCGAATGGAAACGCCATCGAAAGGAAA 
               
               
                   
                   
                   
                 CGAATGGAATTATCATGAAATTGAAATGGATG (SEQ ID NO: 430) 
               
               
                   
               
               
                 425 
                 HGL6.947 
                   
                 GACAAGAGTTCAGAAAGGAAGACTACACAGAAATACGCATTTTAAAGTCACTGA 
               
               
                   
                   
                   
                 CATGGAGATGACACTTAAAACCATGAACATGGATGGG (SEQ ID NO: 431) 
               
               
                   
               
               
                 426 
                 HGL6.956 
                   
                 AAAATAAACGCAAATTAAAATCACAAGATACCAACACATTCCCACGGCTAAGTA 
               
               
                   
                   
                   
                 CGAAGAACAAGGGCGAATGGTCAGAATTAAGCTCAAACCT (SEQ ID NO: 432) 
               
               
                   
               
               
                 427 
                 HGL6.957 
                   
                 TAAACTGACACAAACACAGACACACAGATACACACATACATACAGAAATACACA 
               
               
                   
                   
                   
                 TTCACACACAGACCTGGTCTTTGGAGCCAGAGATG (SEQ ID NO: 433) 
               
               
                   
               
               
                 0 
                 HGL6.958 
                   
                 GATCAATAAATGTAATTCATCATATAAACAGAGAACTAAAGACAAAAACACATG 
               
               
                   
                   
                   
                 ATTATCGCAATACATGCAGAAAAGGCC (SEQ ID NO: 434) 
               
               
                   
               
               
                 429 
                 HGL6.962 
                   
                 AGGACATGAATAGACAATTCTCAAAAGAAGATACACAAGTGGCAAACAAACAC 
               
               
                   
                   
                   
                 ATGAAAAAAGACTCAACATTAGTAATGACCATGGAAATGCAAATC (SEQ ID NO:  
               
               
                   
                   
                   
                 435) 
               
               
                   
               
               
                 430 
                 HGL6.963 
                   
                 ACATCAAACGGAAAAAAACGGAATTATCGAATGGAATCGAAGAGAATCATCGA 
               
               
                   
                   
                   
                 ATGGACC (SEQ ID NO: 436) 
               
               
                   
               
               
                 431 
                 HGL6.965 
                   
                 AATGGACTCGAATAGAATTGACTGGAATGGAATGGACTCGAATGGAATGGAATG 
               
               
                   
                   
                   
                 GAATGGAAGGGACTCG (SEQ ID NO: 437) 
               
               
                   
               
               
                 432 
                 HGL6.966 
                   
                 AAGAAAGACAGAGAACAAACGTAATTCAAGATGACTGATTACATATCCAAGAAC 
               
               
                   
                   
                   
                 ATTAGATGGTCAAAGACTTTAAGAAGGAATACATTCAAAGGCAAAACGTCACTT 
               
               
                   
                   
                   
                 ACTGATTTTGGTGGAGTTTGCCACATGGAC (SEQ ID NO: 438) 
               
               
                   
               
               
                 433 
                 HGL6.967 
                   
                 AACATAATCCATCAAATAAACAGAACCAAAGACAAAAACCACATGATTATCTCA 
               
               
                   
                   
                   
                 ATAGATGCAGAAAAGGCCTTC (SEQ ID NO: 439) 
               
               
                   
               
               
                 434 
                 HGL6.969 
                   
                 GAATGGAATCGAATGGAATGAACATCAAACGGAAAAAAACGGAATTATCGAAT 
               
               
                   
                   
                   
                 GGAATCAAAGAGAATCATCGAATGGACCCG (SEQ ID NO: 440) 
               
               
                   
               
               
                 435 
                 HGL6.972 
                   
                 ATGGACTCGAATGTAATAATCATTGAACGGAATCGAATGGAATCATCATCGGAT 
               
               
                   
                   
                   
                 GGAAACGAATGGAATCATCATCGAATGGAATCGAATGGGATC (SEQ ID NO: 441) 
               
               
                   
               
               
                 436 
                 HGL6.974 
                   
                 GAATGGAATCAACATCAAACGGAATCAAACGGAATTATCGAATGGAATCGAAGA 
               
               
                   
                   
                   
                 GAATCATCGAATGGCCACGAATGGAATCATCTAATGGAATGGAATGGAATAATC 
               
               
                   
                   
                   
                 CATGG (SEQ ID NO: 442) 
               
               
                   
               
               
                 437 
                 HGL6.975 
                   
                 GAAATGGAATGGAAAGGAATAAAATCAAGTGAAATTGGATGGAATGGATTGGA 
               
               
                   
                   
                   
                 ATGGATTGGAATG (SEQ ID NO: 443) 
               
               
                   
               
               
                 438 
                 HGL6.978 
                   
                 AAACGGAAAAAAAACGGAATTATCGAATGGAATCGAAGAGAATCATCGAACGA 
               
               
                   
                   
                   
                 ACCAGAATGGAATCATCTAATGGAATGGAATGGAATAATCCATGG (SEQ ID NO:  
               
               
                   
                   
                   
                 444) 
               
               
                   
               
               
                 439 
                 HGL6.981 
                   
                 ATTAACCCGAATAGAATGGAATGGAATGGAATGGAACGGAACGGAATGGAATG 
               
               
                   
                   
                   
                 GAATGGAATGGAATGGAATGGATCG (SEQ ID NO: 445) 
               
               
                   
               
               
                 440 
                 HGL6.982 
                   
                 GCAAAACACAAACAACGCCATAAAAAACTGGGCAAAGGATATGAACAGACATT 
               
               
                   
                   
                   
                 TTTCAAAACAAAACATACTTATGGCCAAC (SEQ ID NO: 446) 
               
               
                   
               
               
                 441 
                 HGL6.984 
                   
                 AACATCAAACGGAAAAAAACGGAATTATCGTATGGAATCGAAGAGAATCATCGA 
               
               
                   
                   
                   
                 ATGGACC (SEQ ID NO: 447) 
               
               
                   
               
               
                 442 
                 HGL6.985 
                   
                     AAATCAATAAATG   TAATTCAGCATATAAACAGAACCAAAGACAAAAACCACAT 
               
               
                   
                   
                   
                 GATTATCTCAATAGATGCAGAAAAGGCCTTT (SEQ ID NO: 448) 
               
               
                   
               
               
                 443 
                 HGL6.986 
                   
                 AGAATCAAATGGAATTGAATCGAATGGAATCGAATGGATTGGAAAGGAATAGA 
               
               
                   
                   
                   
                 ATGGAATGGAATGGAATG (SEQ ID NO: 449) 
               
               
                   
               
               
                 444 
                 HGL6.988 
                   
                 GAATAGAATTGAATCATCATTGAATGGAATCGAGTAGAATCATTGAAATCGAAT 
               
               
                   
                   
                   
                 GGAATCATCATCGAATGGAATTGGGTGGAATC (SEQ ID NO: 450) 
               
               
                   
               
               
                 445 
                 HGL6.989 
                   
                 CACCGAATAGAATCGAATGGAACAATCATCGAATGGACTCAAATGGAATTATCC 
               
               
                   
                   
                   
                 TCAAATGGAATCGAATGGAATTATCGAATGCAATCGAATAGAATCATCGAATAG 
               
               
                   
                   
                   
                 ACTCGAATGGAATCATCGAATGGAATGGAATGGAACAGTC (SEQ ID NO: 451) 
               
               
                   
               
               
                 446 
                 HGL6.992 
                 HGL6.1286 
                 AAATCATCATCGAATGGAATCGAATGGTATCATTGAATGGAATCGAATGGAATC 
               
               
                   
                   
                   
                 ATCATCAGATGGAAATGAATGGAATCGTCAT (SEQ ID NO: 452) 
               
               
                   
               
               
                 447 
                 HGL6.997 
                   
                 GAATGGAATCGAAAGGAATAGAATGGAATGGATCGTTATGGAAAGACATCGAAT 
               
               
                   
                   
                   
                 GGAATGGAATTGACTCGAATGGAATGGACTGGAATGGAACG (SEQ ID NO: 453) 
               
               
                   
               
               
                 448 
                 HGL6.998 
                   
                 GAATAGAATTGAATCATCATTGAATGGAATCGAGTAGAATCATTGAAATCGAAT 
               
               
                   
                   
                   
                 GGAATCATCATCGAATGGAATTGGGTGGAATC (SEQ ID NO: 454) 
               
               
                   
               
               
                 449 
                 HGL6.1001 
                   
                 GAAAGGAATAGAATGGAATGGATCGTTATGGAAAGACATCGAATGGGATGGAA 
               
               
                   
                   
                   
                 TTGACTCGAATGGATTGGACTGGAATGGAACGGACTCGAATGGAATGGACTGGA 
               
               
                   
                   
                   
                 ATG (SEQ ID NO: 455) 
               
               
                   
               
               
                 450 
                 HGL6.1003 
                   
                 TGGATTTCAGATATTTAACACAAAATAGTCAAAGCAGATAAATACTAGCAACTT 
               
               
                   
                   
                   
                 ATTTTTAATGGGTAACATCATATGTTCGTGCCTT (SEQ ID NO: 456) 
               
               
                   
               
               
                 451 
                 HGL6.1004 
                   
                 ACAGCAGAAAACGAACATCAGAAAATCACTCTACATGATGCTTAAATACAGAGG 
               
               
                   
                   
                   
                 GCAAGCAACCCAAGAGAAAACACCACTTCCTAAT (SEQ ID NO: 457) 
               
               
                   
               
               
                 452 
                 HGL6.1011 
                   
                 AACATACACAAATCAATAAACGTAATCCAGCTTATAAACAGAACCAAAGACAAA 
               
               
                   
                   
                   
                 AACCACATGATTATCTCAATAGATGCGGAAAAGGCC (SEQ ID NO: 458) 
               
               
                   
               
               
                 453 
                 HGL6.1012 
                   
                 ACATCAAACGGAATCAAACGGAATTATCGAATGGAATCGAAAAGAATCATCGAA 
               
               
                   
                   
                   
                 CGGACTCGAATGGAATCATCTAATGGAATGGAATGGAAG (SEQ ID NO: 459) 
               
               
                   
               
               
                 454 
                 HGL6.1013 
                   
                 ATCGAATGGAATCAACATCAAACGGAAAAAAACGGAATTATCAAATGGAATCGA 
               
               
                   
                   
                   
                 AGAGAATCATCGAATGGACC (SEQ ID NO: 460) 
               
               
                   
               
               
                 455 
                 HGL6.1014 
                   
                 GAATAATCATTGAACGGAATCGAATGGAAACATCATCGAATGGAAACGAATGGA 
               
               
                   
                   
                   
                 ATCATCATCGAATGGAAATGAAAGGAGTCATC (SEQ ID NO: 461) 
               
               
                   
               
               
                 456 
                 HGL6.1015 
                   
                 CATCAAACGGAATCAAACGGAATTATCGAATGGAATCGAAAAGAATCATCGAAC 
               
               
                   
                   
                   
                 GGACTCGAATGGAATCATCTAATGGAATGGAATGGAAGAATCCATGGACTCGAA 
               
               
                   
                   
                   
                 TG (SEQ ID NO: 462) 
               
               
                   
               
               
                 457 
                 HGL6.1016 
                   
                 TCCAGTCGATCATCATATAGTCAGCACTTATCATACACCAAGCCGTGTGCAAGGA 
               
               
                   
                   
                   
                 AAGGGAATACAACCATGAACATGATAGATGGATGGTT (SEQ ID NO: 463) 
               
               
                   
               
               
                 458 
                 HGL6.1017 
                   
                 ACAAACCACTGCTCAAGGAAATAAGGACACAAACAAATGGAACAACATTCCGTG 
               
               
                   
                   
                   
                 CTCATGGATAGGAAGAATCAATATCGTGAAAATGGCCATACT (SEQ ID NO: 464) 
               
               
                   
               
               
                 459 
                 HGL6.1019 
                   
                 ACAAAATTGATAGACCACTAGCAAGACTAATAAAGAAGAAAAGAGAGAAGAAT 
               
               
                   
                   
                   
                 CATTACCATTCAGGACATAGGCATGGGCAAGGAC (SEQ ID NO: 465) 
               
               
                   
               
               
                 460 
                 HGL6.1024 
                   
                 AAACGGAATCAAACGGAATTATCGAATGGAATCGAAGAGAATCATCGAATGGAC 
               
               
                   
                   
                   
                 TCGAATGGAATCATCTAATGGAATGGAATGGAAGAATCCATGG (SEQ ID NO: 466) 
               
               
                   
               
               
                 461 
                 HGL6.1026 
                   
                 ATACAC   AAATCAATAAATG   TAATCCAGCATATAAACAGAACCAAAGACAAAAA 
               
               
                   
                   
                   
                 CCATATGATTATCTCAATGGATGCAGAAAAGGCC (SEQ ID NO: 467) 
               
               
                   
               
               
                 462 
                 HGL6.1027 
                   
                 AATNGAATAGAATCATCGAATGGACTCGAATGGAATCATCGANNNTANTGATGG 
               
               
                   
                   
                   
                 AACAGTC (SEQ ID NO: 468) 
               
               
                   
               
               
                 463 
                 HGL6.1030 
                   
                 TGGAATGGAATCATCGCATAGAATCGAATGGAATTACCATCGAATGGGATCGAA 
               
               
                   
                   
                   
                 TGGTATCAACATCAAACGCAAAAAAACGGAATTATCGAATGGAATCGAAGAGAA 
               
               
                   
                   
                   
                 TCTTCGAACGGACCCG (SEQ ID NO: 469) 
               
               
                   
               
               
                 464 
                 HGL6.1031 
                   
                 GAATTGAATTGAATGGAATGGAATGCAATGGAATCTAATGAAACGGAAAGGAA 
               
               
                   
                   
                   
                 AGGAATGGAATGGAATGGAATG (SEQ ID NO: 470) 
               
               
                   
               
               
                 465 
                 HGL6.1033 
                   
                 AACAGAATGGAATCAAATCGAATGAAATGGAATGGAATAGAAAGGAATGGAAT 
               
               
                   
                   
                   
                 GAAATGGAATGGAAAGGATTCGAATGGAATGCAATCG (SEQ ID NO: 471) 
               
               
                   
               
               
                 466 
                 HGL6.1034 
                   
                 ATGGAATGGAATGGAATGGAATTAAATGGAATGGAAAGGAATGGAATCGAATG 
               
               
                   
                   
                   
                 GAAAGGAATC (SEQ ID NO: 472) 
               
               
                   
               
               
                 467 
                 HGL6.1037 
                 HGL6.1245 
                 GTCGAAATGAATAGAATGCAATCATCATCAAATGGAATCCAATGGAATCATCAT 
               
               
                   
                   
                   
                 CAAATAGAATCGAATGGAATCATCAAATGGAATCGAATGGAGTCATTG (SEQ ID 
               
               
                   
                   
                   
                 NO: 473) 
               
               
                   
               
               
                 468 
                 HGL6.1039 
                   
                 TGGAATTATCGAAAGCAAACGAATAGAATCATCGAATGGACTCGAATGGAATCA 
               
               
                   
                   
                   
                 TCGAATGGAATGGAATGGAACAG (SEQ ID NO: 474) 
               
               
                   
               
               
                 469 
                 HGL6.1045 
                   
                 AAAGGAATGGAATGCAATGGAATGCAATGGAATGCACAGGAATGGAATGGAAT 
               
               
                   
                   
                   
                 GGAATGGAAAGGAATG (SEQ ID NO: 475) 
               
               
                   
               
               
                 470 
                 HGL6.1046 
                   
                 AATCTAATGGAATCAACATCNAACGGAAAAAAACGGAATTATCGAATGGAATCN 
               
               
                   
                   
                   
                 AAGAGAATCATCNAATGGACC (SEQ ID NO: 476) 
               
               
                   
               
               
                 471 
                 HGL6.1047 
                   
                 TACACAACAAAAGAAATACTCAACACAGTAAACAGACAACCTTCAGAACAGGA 
               
               
                   
                   
                   
                 GAAAATATTTGCAAATACATCTAACAAAGGGCTAATATCCAGAATCT (SEQ ID 
               
               
                   
                   
                   
                 NO: 477) 
               
               
                   
               
               
                 472 
                 HGL6.1048 
                   
                 NGCAATCNTAGTNTCAGATAAAACAGACATTAAACCAACAAAGATCAAAAGAG 
               
               
                   
                   
                   
                 ACAAAGAAGGCCANTAC (SEQ ID NO: 478) 
               
               
                   
               
               
                 473 
                 HGL6.1052 
                   
                 GAATCGAATGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATC 
               
               
                   
                   
                   
                 NAAAAGAATCATCNAATGGACC (SEQ ID NO: 479) 
               
               
                   
               
               
                 474 
                 HGL6.1055 
                   
                 ACAGTTAACAAAAACCGAACAATCTAATTACGAAATGAACAAAAGATATGAACA 
               
               
                   
                   
                   
                 GACATTTCACCCGAGAGTATACAGGGGCCAGGCATGGT (SEQ ID NO: 480) 
               
               
                   
               
               
                 475 
                 HGL6.1056 
                   
                 AATGGAATCGAATGGAATGCAATCCAATGGAATGGAATGCAATGCAATGGAATG 
               
               
                   
                   
                   
                 GAATCGAACGGAATGCAGTGGAAGGGAATGG (SEQ ID NO: 481) 
               
               
                   
               
               
                 476 
                 HGL6.1057 
                   
                 GAACACAGAAAAATTTCAAAGGAATAATCAACAGGGATTGATAACTAACTGGAT 
               
               
                   
                   
                   
                 TTAGAGAGCCAAGGCAAAGAGAATCAAAGCACAGGGCCTGAGTCGGAG (SEQ ID 
               
               
                   
                   
                   
                 NO: 482) 
               
               
                   
               
               
                 477 
                 HGL6.1058 
                   
                 TATACCACACAAATGCAAAAGATTATTAGCAACAATTATCAACAGCAATATGTC 
               
               
                   
                   
                   
                 AACAAGTTGACAAACCTAGAGGACATGGAT (SEQ ID NO: 483) 
               
               
                   
               
               
                 478 
                 HGL6.1061 
                   
                 CACCATGAGTCATTAGGTAAATGCAAATCAAAACCACAATGAAATACTTCACAC 
               
               
                   
                   
                   
                 CCATGAAGATGGCTATAATAAAAAAACAGACA (SEQ ID NO: 484) 
               
               
                   
               
               
                 479 
                 HGL6.1067 
                   
                 AGTTGAATAGAACCAATCCGAATGAAATGGAATGGAATGGAACGGAATGGAATT 
               
               
                   
                   
                   
                 GAATGGAATGGAATGGAATGCAATGGA (SEQ ID NO: 485) 
               
               
                   
               
               
                 480 
                 HGL6.1069 
                   
                 AAGTAATAAGACTGAATTAGTAATACAAAGTGTCTCAACAAAGAAAATTGCGGG 
               
               
                   
                   
                   
                 ACTGTTCATGCTCATGGACAGGAAGAATCAATATCATGAAAATGGCC (SEQ ID 
               
               
                   
                   
                   
                 NO: 486) 
               
               
                   
               
               
                 481 
                 HGL6.1070 
                   
                 AACTCGATTGCAATGGAATGTAATGTAATGGAATGGAATGGAATTAACGCGAAT 
               
               
                   
                   
                   
                 AGAATGGAATGGAATGTAATGGAACGGAATGGAATG (SEQ ID NO: 487) 
               
               
                   
               
               
                 482 
                 HGL6.1074 
                   
                 AAGCGGAATAGAATTGAATCATCATTGAATGGAATCGAGTAGAATCATTGAAAT 
               
               
                   
                   
                   
                 CGAATGGAATCATAGAATGGAATCCAAT (SEQ ID NO: 488) 
               
               
                   
               
               
                 483 
                 HGL6.1076 
                   
                 AAAGGAAAACTACAAAACACTGCTGAAAGAAATCATTGACAACACAAACAAAT 
               
               
                   
                   
                   
                 GGAAACACATCCCAAGATCATGGGTGGGTGGAATCAAT (SEQ ID NO: 489) 
               
               
                   
               
               
                 484 
                 HGL6.1077 
                   
                 AATGGAATCNAAAGGAATAGAATGGAATGGATCGTTATGGAAAGATATCGAATG 
               
               
                   
                   
                   
                 GAATGGAATTGACTCGAATGGAATGGACTGGAATGGAACG (SEQ ID NO: 490) 
               
               
                   
               
               
                 485 
                 HGL6.1078 
                   
                 TAACGGAATAATCATCGAACAGAATCAAATGGAATCATCATTGAATGGAATTGA 
               
               
                   
                   
                   
                 ATGGAATCTTCGAATAGACATGAATGGACCATCATCG (SEQ ID NO: 491) 
               
               
                   
               
               
                 486 
                 HGL6.1084 
                   
                 AAAGACCGAAACAACAACAGAAACAGAAACAAACAACAATAAGAAAAAATGTT 
               
               
                   
                   
                   
                 AAGCAAAACAAATGATTGCACAACTTACATGATTACTGAGTGTTCTAATGGT 
               
               
                   
                   
                   
                 (SEQ ID NO: 492) 
               
               
                   
               
               
                 487 
                 HGL6.1085 
                   
                 AAGATTTAAACATAAGACCTAAAACGACAAAAATCCTAGGAGAAAACCTAAGCA 
               
               
                   
                   
                   
                 ATACCATTCAGGACATAGGCATGGGCAAAGACTTCATG (SEQ ID NO: 493) 
               
               
                   
               
               
                 488 
                 HGL6.1090 
                   
                 AGAAACAGCCAGAAAACAATTATTACCTACAGCATTAAAACTATTCAAATGACA 
               
               
                   
                   
                   
                 GCATATTTTTCAGCAGAAATCATGAAGGCCAGAAGGACGTGTCAT (SEQ ID NO: 
               
               
                   
                   
                   
                 494) 
               
               
                   
               
               
                 489 
                 HGL6.1092 
                   
                 ATGTACAC   AAATCAATAAATG   CAGTCCAGCATATAAACAGAACCAAACACAAA 
               
               
                   
                   
                   
                 AACCACATGATTATCTCAATAGATGCAGAAAAGGCCTTT (SEQ ID NO: 495) 
               
               
                   
               
               
                 490 
                 HGL6.1093 
                   
                 AGCAACTTCAGCAAAGTCTCAGGACACAAAATCAATGTGCAAAAATCACAAGCA 
               
               
                   
                   
                   
                 TTCTTATACACCAATAACAGACAAACAGAGAGCC (SEQ ID NO: 496) 
               
               
                   
               
               
                 491 
                 HGL6.1094 
                   
                 TTGAATCGAATGGAATCGAATGGATTGGAAAGGAATAGAATGGAATGGAATGGA 
               
               
                   
                   
                   
                 ATTGACTCAAATGGAATG (SEQ ID NO: 497) 
               
               
                   
               
               
                 492 
                 HGL6.1097 
                 HGL6.1241 
                 AACGGAATCAAACGGAATTATCGAATGGAATCGAATAGAATCATCGAACGGACT 
               
               
                   
                   
                   
                 CGAATGGAATCATCTAATGGAATGGAATGGAAG (SEQ ID NO: 498) 
               
               
                   
               
               
                 493 
                 HGL6.1098 
                   
                 AACATCACTGATCATTAGAAACACACAAATCAAAACCACAATAAGATACCATCT 
               
               
                   
                   
                   
                 AACACCAGTCACAATGGCTATT (SEQ ID NO: 499) 
               
               
                   
               
               
                 494 
                 HGL6.1100 
                   
                 TAAGCAATTTCAGCAGTCTCAGGATACAAAATCAATGTGCAAAAATCACAAGCA 
               
               
                   
                   
                   
                 TTCTTATACACCAACAACAGACAAACAGAGAGCCAAATCG (SEQ ID NO: 500) 
               
               
                   
               
               
                 495 
                 HGL6.1101 
                   
                 AGAAAAAAACAAACAGCCCATTAAAAGGTAGACAAAGGACATGAACACTTTTCA 
               
               
                   
                   
                   
                 AAAGAAGACATACATGTGGCCAAACAGCATG (SEQ ID NO: 501) 
               
               
                   
               
               
                 496 
                 HGL6.1103 
                   
                 ATTGGAATGGAACGGAACAGAACGGAATGGAATGGAATAGAATGGAATGGAAT 
               
               
                   
                   
                   
                 GGAATGGTATGGAATGGAATGGAATGGTACG (SEQ ID NO: 502) 
               
               
                   
               
               
                 497 
                 HGL6.1104 
                   
                 AGAGCATCCACAAGGCCCAATTCAAAGAATCTGAAATAATGTATTGTTACTGCA 
               
               
                   
                   
                   
                 ACAGTTGTGAGTACCAGTGGCATCAG (SEQ ID NO: 503) 
               
               
                   
               
               
                 498 
                 HGL6.1107 
                   
                 AATCCACAAAGACAACAGAAGAAAAGACAACAGTAGACAAGGATGTCAACCAC 
               
               
                   
                   
                   
                 ATTTTGGAAGAGACAAGTAATCAAACACATGGCA (SEQ ID NO: 504) 
               
               
                   
               
               
                 499 
                 HGL6.1109 
                   
                 AAACAGAACCACAGATATCTGTAAAGGATTACACTATAGTATTCAACAGAGTAT 
               
               
                   
                   
                   
                 GGAACAGAGTATAGTATTCAACAGAGTATGCAAAGAAACTAAGGCCAGAAAG 
               
               
                   
                   
                   
                 (SEQ ID NO: 505) 
               
               
                   
               
               
                 500 
                 HGL6.1110 
                   
                 AGCAAACAAACAAACAAACAAACAAACTATGACAGGAACAAAACGTCACATAT 
               
               
                   
                   
                   
                 CAACATTAACAAAGAATGTAAACAGCCTAAATGCTTCACTTAAAAGTTATAGAC 
               
               
                   
                   
                   
                 AGGGGCTGGGCATGGTGGCTCACGCC (SEQ ID NO: 506) 
               
               
                   
               
               
                 501 
                 HGL6.1111 
                   
                 AAAAGTACAGAAGACAACAAAAAATGAGAGAGAGAAAGATAACAGACTATAGC 
               
               
                   
                   
                   
                 AGCATTGGTGATCAGAGCCACCAG (SEQ ID NO: 507) 
               
               
                   
               
               
                 502 
                 HGL6.1114 
                   
                 TACAAGAAAATCACAGTAACATTTATAAAACACAGAAGTGTGAACACACAGCTA 
               
               
                   
                   
                   
                 TTGACCTTGAAAACAGTGAAAGAGGGTCAGCTGTAGAACTAAGACATAAGCAAA 
               
               
                   
                   
                   
                 GTTTTTCAATCAAGAATACATGGGTGGCC (SEQ ID NO: 508) 
               
               
                   
               
               
                 503 
                 HGL6.1116 
                   
                 GAATCGAATGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATC 
               
               
                   
                   
                   
                 GAAAAGAATCATCGAACGGACTCGAATGGAATCATCTAATGGAATGGAATGGAA 
               
               
                   
                   
                   
                 GAATCCATGG (SEQ ID NO: 509) 
               
               
                   
               
               
                 504 
                 HGL6.1117 
                   
                 AATGGAATCGAATGGAATCATCATCAAATGGAATCTAATGGAATCATTGAACGG 
               
               
                   
                   
                   
                 AATTGGATGGAATCGTCAT (SEQ ID NO: 510) 
               
               
                   
               
               
                 505 
                 HGL6.1118 
                   
                 AACGGAATCAAACGGAATTATCGAATGGAATCGAAGAGAATCATCGAATGGCCA 
               
               
                   
                   
                   
                 CGAATGGAATCATCTAATGGAATGGAATGGAATAATCCATGGACCCGAATG 
               
               
                   
                   
                   
                 (SEQ ID NO: 511) 
               
               
                   
               
               
                 506 
                 HGL6.1121 
                   
                 CAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATCGAAGAGAATCATC 
               
               
                   
                   
                   
                 GAATGGACC (SEQ ID NO: 512) 
               
               
                   
               
               
                 507 
                 HGL6.1122 
                   
                 CACAACCAAAGCAATGAAAGAAAAGCACAGACTTATTGAAATGAAAGTACACA 
               
               
                   
                   
                   
                 CCACAGAATGGGAGCAGGCTCAAGCAAGC (SEQ ID NO: 513) 
               
               
                   
               
               
                 508 
                 HGL6.1123 
                 HGL6.1229 
                 ATCAAAGGGAATCAAGCGGAATTATCGAATGGAATCGAAGAGAATCATCGAATG 
               
               
                   
                   
                   
                 GACTCGAATGGAATCATGTGATGGAATGGAATGGAATAATCCACGGACT (SEQ ID 
               
               
                   
                   
                   
                 NO: 514) 
               
               
                   
               
               
                 509 
                 HGL6.1125 
                   
                 AAGAAACAATCAAAAGGAAGTGCTAGAAATAAAACACACTGTAATAGAAAAGA 
               
               
                   
                   
                   
                 AGAATGCCTTATGGGCTTATCAATAGACTAGACATGGCCAGG (SEQ ID NO: 515) 
               
               
                   
               
               
                 510 
                 HGL6.1127 
                   
                 AGATAAGAATAAGGCAAACATAGTAATAGGGAGTTCATGAATAACACACGGAA 
               
               
                   
                   
                   
                 AGAGAACTTACAGGGCTGTGATCAGGAAACG (SEQ ID NO: 516) 
               
               
                   
               
               
                 511 
                 HGL6.1128 
                   
                 GGAATCGAATGGAATCAATATCAAACGGAGAAAAACGGAATTATCGAATGGAAT 
               
               
                   
                   
                   
                 CGAAGAGAATCATCGAATGGACC (SEQ ID NO: 517) 
               
               
                   
               
               
                 512 
                 HGL6.1130 
                   
                 TCAGACCATAGCAGATAACATGCACATTAGCAATACGATTGCCATGACAGAGTG 
               
               
                   
                   
                   
                 GTTGGTG (SEQ ID NO: 518) 
               
               
                   
               
               
                 513 
                 HGL6.1132 
                   
                 AGGAATGGACACGAACGGAATGCAATCGAATGGAATGGAATCTAATAGAAAGG 
               
               
                   
                   
                   
                 AATTGAATGAAATGGACTGG (SEQ ID NO: 519) 
               
               
                   
               
               
                 514 
                 HGL6.1133 
                   
                 GGAAGGGAATCAAATGCAACAGAATGTAATGGAATGGAATGCAATGGAATGCA 
               
               
                   
                   
                   
                 ATGGAATGGAATGGAATGCAATGGAATGG (SEQ ID NO: 520) 
               
               
                   
               
               
                 515 
                 HGL6.1138 
                   
                 AAATTGGATTGAATCGAATCGAATGGAAAAAATGAAATCAAATGAAATTGAATG 
               
               
                   
                   
                   
                 GAATCGAAATGAATGTAAACAATGGAATCCAATGGAATCCAATGGAATCGAATC 
               
               
                   
                   
                   
                 AAATGGTTTTGAGTGGCGTAAAATG (SEQ ID NO: 521) 
               
               
                   
               
               
                 516 
                 HGL6.1139 
                   
                 AAGGATTCGAATGGAATGCAATCGAATGGAATGGAATCGAACGGAATGGAATA 
               
               
                   
                   
                   
                 AAATGGAAGAAAACTGGCAAGAAATGGAATCG (SEQ ID NO: 522) 
               
               
                   
               
               
                 517 
                 HGL6.1141 
                   
                 GAAAAATCATTGAACGGAATCGAATGGAATCATCATCGGATGGAAACGAATGGA 
               
               
                   
                   
                   
                 ATCATCATCGAATGGAAATGAAAGGAGTCATC (SEQ ID NO: 523) 
               
               
                   
               
               
                 518 
                 HGL6.1147 
                   
                 GGTTCAACTTACAATATTTTGACTTGACAACAGTGCAAAAGCAATACACGATTAG 
               
               
                   
                   
                   
                 TAGAAACACACTTCCAATGCCCATAGGACCATTCTGC (SEQ ID NO: 524) 
               
               
                   
               
               
                 519 
                 HGL6.1150 
                   
                 GGAATCGAATGGAATCAACATCAAACGGAGAAAAACGGAATTATCGAATGGAA 
               
               
                   
                   
                   
                 TCGAAGAGAATCATCGAATGGACC (SEQ ID NO: 525) 
               
               
                   
               
               
                 520 
                 HGL6.1152 
                   
                 TAACCTGATTTGCCATAATCCACGATACGCTTACAACAGTGATATACAAGTTACA 
               
               
                   
                   
                   
                 TGAGAAACACAAACATTTTGCAAGGAAACTGTGGCCAGATG (SEQ ID NO: 526) 
               
               
                   
               
               
                 521 
                 HGL6.1153 
                   
                 TAACTACTCACAGAACTCAACAAAACACTATACATGCATTTACCAGTTTATTATA 
               
               
                   
                   
                   
                 AAGATACAAGTCAGGAACAGCCAAATGGAAGAAATGTAAATGGCAAG (SEQ ID 
               
               
                   
                   
                   
                 NO: 527) 
               
               
                   
               
               
                 522 
                 HGL6.1155 
                   
                 GCTCAAAGAAATCAGAAATGACACAAGCAAATGGAAAAACATGCCATGTTCATG 
               
               
                   
                   
                   
                 AATATGAAGAATCAATATTGTTAAAATGGCCATACTGCTCA (SEQ ID NO: 528) 
               
               
                   
               
               
                 523 
                 HGL6.1157 
                   
                 AAAGAAATGTCACTGCGTATACACACACACGCACATACACACACCATGGAATAC 
               
               
                   
                   
                   
                 TACTCAGCTATACAAAGGAATGAAATAATCCACAGCCAC (SEQ ID NO: 529) 
               
               
                   
               
               
                 524 
                 HGL6.1159 
                   
                 GAATAGAACAGAATGGAATCAAATCGAATGAAATGGAATGGAATAGAAAGGAA 
               
               
                   
                   
                   
                 TGGAATGAAATGGAATGGAAAGGATTCGAATGGAATG (SEQ ID NO: 530) 
               
               
                   
               
               
                 525 
                 HGL6.1162 
                   
                 TGAACGGAATCGAATGGAATCATCATCGGATGGAAACGAATGGAATCATCATCG 
               
               
                   
                   
                   
                 AATGGAAATGAAAGGAGTCATC (SEQ ID NO: 531) 
               
               
                   
               
               
                 526 
                 HGL6.1165 
                   
                 GAATAGAACGAAATGGAATGGAATGGAATGGAATGGAAAGGAATGGAATGGAA 
               
               
                   
                   
                   
                 TGGAACG (SEQ ID NO: 532) 
               
               
                   
               
               
                 527 
                 HGL6.1166 
                   
                 AACGTGACATACATACAAAAAGTTTTTAGAGCAAGTGAAATTTTAGCTGCTATAT 
               
               
                   
                   
                   
                 GTTAATTGGTGGTAATCCC (SEQ ID NO: 533) 
               
               
                   
               
               
                 528 
                 HGL6.1169 
                   
                 GGAATAACAACAACAACAACCAAAAGACATATAGAAAACAAACAGCACGATGG 
               
               
                   
                   
                   
                 CAGATGTAAAGCCTACC (SEQ ID NO: 534) 
               
               
                   
               
               
                 529 
                 HGL6.1174 
                   
                 GACAAAAAGAATCATCATCGAATAGAATCAAATGGAATCTTTGAATGGACTCAA 
               
               
                   
                   
                   
                 AAGGAATATCGTCAAATGGAATCAAAAGCCATCATCGAATGGACTGAAATGGAA 
               
               
                   
                   
                   
                 TTATCAAATGGACTCG (SEQ ID NO: 535) 
               
               
                   
               
               
                 530 
                 HGL6.1175 
                   
                 GTAACAAAACAGACTCATAGACCAATAGAACAGAATAGAGAATTCAGAAATAA 
               
               
                   
                   
                   
                 GACTGCACTTCTATGACCATGTGATCTTAGACAAACCT (SEQ ID NO: 536) 
               
               
                   
               
               
                 531 
                 HGL6.1176 
                   
                 AGATAAAAAGAACAGCAGCCAAAATGACAAAAGCAAAAAGCAAAATCGTGTTA 
               
               
                   
                   
                   
                 GAGCCAGGTGTGGTGATGTGTGCT (SEQ ID NO: 537) 
               
               
                   
               
               
                 532 
                 HGL6.1178 
                   
                 GCAATCTCAGGATACAAAATCAATGTGCAAAAATCACAAGCATTCTCATACACC 
               
               
                   
                   
                   
                 AATAACAGACAAACAGAGCCAAATCATG (SEQ ID NO: 538) 
               
               
                   
               
               
                 533 
                 HGL6.1179 
                   
                 AACCAAACCAAGCAAACAAACAAACAGTAAAAACTCAATAACAACCAACAAAC 
               
               
                   
                   
                   
                 AGGAAATACCAGGTAATTCAGATTATCTAGTTATGTGCCATAGT (SEQ ID NO: 
               
               
                   
                   
                   
                 539) 
               
               
                   
               
               
                 534 
                 HGL6.1181 
                   
                 GAATGAATTGAATGCAAACATCGAATGGTCTCGAATGGAATCATCTTCAAATGG 
               
               
                   
                   
                   
                 AATGGAATGGAATCATCGCATAGAATCGAATGGAATTATCAACGAATGGAATCG 
               
               
                   
                   
                   
                 AATGGAATCATCATCAGATGGAAATGAATGGAATCGTCAT (SEQ ID NO: 540) 
               
               
                   
               
               
                 535 
                 HGL6.1183 
                   
                 TGGAATGGAATCAAATCGCATGGAATCGAATGGAATAGAAAAGAATCAAACAG 
               
               
                   
                   
                   
                 AGTGGAATGGAATGGAATGGAATGGAATCATGCCGAATGGAATG (SEQ ID NO: 
               
               
                   
                   
                   
                 541) 
               
               
                   
               
               
                 536 
                 HGL6.1184 
                   
                 GAATCCATGTTCATAGCACAACAACCAAACAGAAGAAATCACTGTGAAATAAGA 
               
               
                   
                   
                   
                 AACAAAGCAAAACACAGATGTCGACACATGGCA (SEQ ID NO: 542) 
               
               
                   
               
               
                 537 
                 HGL6.1185 
                   
                 AAATGGAATAATGAAATGGAATCGAACGGAATCATCATCAAAAGGAACCGAAT 
               
               
                   
                   
                   
                 GAAGTCATTGAATGGAATCAAAGGCAATCATGGTCGAATGGAATCAAATGGAAA 
               
               
                   
                   
                   
                 CAGCATTGAATAGAATTGAATGGAGTCATCACATGGAATCG (SEQ ID NO: 543) 
               
               
                   
               
               
                 538 
                 HGL6.1186 
                   
                 GAATTAACCCGAATAGAATGGAATGGAATGGAATGGAACAGAACGGAACGGAA 
               
               
                   
                   
                   
                 TGGAATGGAATGGAATGGAATGGAATG (SEQ ID NO: 544) 
               
               
                   
               
               
                 539 
                 HGL6.1188 
                   
                 AAGATATACAAGCAGCCAACAAACATACGAAAGAATGCTCAACATCACTAATCC 
               
               
                   
                   
                   
                 TCAGAGAAATTTAAATCAAAACCACAATGAGTTACAATCTCATACCAGTCAGAA 
               
               
                   
                   
                   
                 T (SEQ ID NO: 545) 
               
               
                   
               
               
                 540 
                 HGL6.1190 
                   
                 AGAATTACAAACCACTGCTCAACAAAATAAAAGAGTACACAAACAAATGGAAG 
               
               
                   
                   
                   
                 AATATTCCATGCTTATGGATAGGAAGAATCAATATTGTGAAAATGGCCATACT 
               
               
                   
                   
                   
                 (SEQ ID NO: 546) 
               
               
                   
               
               
                 541 
                 HGL6.1192 
                   
                 CATCGAATGGACTCGAATGGAATAATCATTGAACGGAATCGAAGGGAATCATCA 
               
               
                   
                   
                   
                 TCGGATGGAAACGAATGGAATCATCATCGAATGGAAATG (SEQ ID NO: 547) 
               
               
                   
               
               
                 542 
                 HGL6.1194 
                   
                 CACCCATCTGTAGGACCAGGAAGCCTGATGTGGGAGAGAACAGCAGGCTAAATC 
               
               
                   
                   
                   
                 CAGGGTTGGTCTCTACAGCAGAGGGAATCACAAGCCTGTTAGCAAGTGAAGAAC 
               
               
                   
                   
                   
                 CAACACTGGCAAGAGTGTGAAGGCC (SEQ ID NO: 548) 
               
               
                   
               
               
                 543 
                 HGL6.1195 
                   
                 TAATGCAAACTAAAACGACAATGAGATATCAATACATAACTACCAGAAAGGCTA 
               
               
                   
                   
                   
                 ACAAAAAAACAGTCATAACACACCAAAGGCTGATGAGTGAGGATGTGCAG (SEQ 
               
               
                   
                   
                   
                 ID NO: 549) 
               
               
                   
               
               
                 544 
                 HGL6.1196 
                   
                 AAAGGAATCAAACGGAATTATCGAATGGAATCGAAAAGAATCATCGAACGGACT 
               
               
                   
                   
                   
                 CGAATGGAATCATCTAATGGAATGGAATGGAAGAATCCATGGACTCGAATG 
               
               
                   
                   
                   
                 (SEQ ID NO: 550) 
               
               
                   
               
               
                 545 
                 HGL6.1198 
                   
                 AGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGAGCAAAAATCACAAGCA 
               
               
                   
                   
                   
                 TTCTTACACACCAATAACAGACAAACAGAGAGCC (SEQ ID NO: 551) 
               
               
                   
               
               
                 546 
                 HGL6.1199 
                   
                 GGATATAAACAAGAAAACAACTAATCACAACTCAATATCAAAGTGCAATGATGG 
               
               
                   
                   
                   
                 TGCAAAATGCAAGTATGGTGGGGACAGAGAAAGGATGC (SEQ ID NO: 552) 
               
               
                   
               
               
                 547 
                 HGL6.1200 
                   
                 AATCAGTAAACGTAATACAGCATATAAACAGAACCAAAGACAAAAACCACATG 
               
               
                   
                   
                   
                 ATTATCTCAATAGATGCAGAAAAGGCC (SEQ ID NO: 553) 
               
               
                   
               
               
                 548 
                 HGL6.1202 
                   
                 AACATCAAACGGAAAAAAACGGAAATATCGAATGGAATCGAAGAGAATCATCG 
               
               
                   
                   
                   
                 AATGGACC (SEQ ID NO: 554) 
               
               
                   
               
               
                 549 
                 HGL6.1203 
                   
                 TAAAATGGAATCGAATGGAATCAACATCAAATGGAATCAAATGGAATCATTGAA 
               
               
                   
                   
                   
                 CGGAATTGAATGGAATCGTCAT (SEQ ID NO: 555) 
               
               
                   
               
               
                 550 
                 HGL6.1204 
                   
                 AATCATCATCGAATGGAATCGAATGGTATCATTGAATGGAATCGAATGGAATCA 
               
               
                   
                   
                   
                 TCATCAGATGGAAATGAATGGAATCGTCAT (SEQ ID NO: 556) 
               
               
                   
               
               
                 551 
                 HGL6.1205 
                   
                 CAATGCGTCAAGCTCAGACGTGCCTCACTACGGCAATGCGTCAAGCTCAGGCGT 
               
               
                   
                   
                   
                 GCCTCACTAT (SEQ ID NO: 557) 
               
               
                   
               
               
                 552 
                 HGL6.1206 
                   
                 AAGACAGAACACTGAAACTCAACAGAGAAGTAACAAGAACACCTAAGACAAGG 
               
               
                   
                   
                   
                 AAGGAGAGGGAAGGCAGGCAG (SEQ ID NO: 558) 
               
               
                   
               
               
                 553 
                 HGL6.1209 
                   
                 TAAGCTGATAAGCAACTTTAGCAAAGTCTCAGGATACAAAATCAATGTACAAAA 
               
               
                   
                   
                   
                 ATCACAAGCATTCTTATACACCAACAACAGACAGACGGAGAGCCAAA (SEQ ID 
               
               
                   
                   
                   
                 NO: 559) 
               
               
                   
               
               
                 554 
                 HGL6.1212 
                   
                 ATGAACACGAATGTAATGCAATCCAATAGAATGGAATCGAATGGCATGGAATAT 
               
               
                   
                   
                   
                 AAAGAAATGGAATCGAAGAGAATGGAAACAAATGGAATGGAATTGAATGGAAT 
               
               
                   
                   
                   
                 GGAATTG (SEQ ID NO: 560) 
               
               
                   
               
               
                 555 
                 HGL6.1216 
                   
                 AACAATCACTAGTCCTTAAGTAAGAGACAACACCTTTTGTCACACACAGTTTGTC 
               
               
                   
                   
                   
                 CTAACTTTATCTTGGTAATTGGGGAGACC (SEQ ID NO: 561) 
               
               
                   
               
               
                 556 
                 HGL6.1217 
                   
                 TAATGAGAAGACACAGACAACACAAAGAATCACAGAAACATGACACAGGTGAC 
               
               
                   
                   
                   
                 AAGAACAGGCAAGGACCTGCAGTGCACAGGAGCC (SEQ ID NO: 562) 
               
               
                   
               
               
                 557 
                 HGL6.1218 
                   
                 TGTTGAGAGAAATTAAACAAAGCACAGATAAATGGAAAAACGTGTTCATAGATT 
               
               
                   
                   
                   
                 GAAAGACTTCATGTTGTATGGTGTC (SEQ ID NO: 563) 
               
               
                   
               
               
                 558 
                 HGL6.1219 
                   
                 ATCAAACGGAATCAAACGGAATTATCGAATGGAATCGAAGAGAATCATCGAACG 
               
               
                   
                   
                   
                 GACTCGAATGGAATCATCTAATGGAATGGGATGG (SEQ ID NO: 564) 
               
               
                   
               
               
                 559 
                 HGL6.1222 
                   
                 ACACAACAACCAAGAAACAACCCCATTAAGAAGTGGGAAAAATACATGAATAA 
               
               
                   
                   
                   
                 ACACATCTCAAAAGAAGACAAACAAGTGGCTAAC (SEQ ID NO: 565) 
               
               
                   
               
               
                 560 
                 HGL6.1225 
                   
                 AATGGAAAGGAATCAAATGGAATATAATGGAATGCAATGGACTCGAATGGAATG 
               
               
                   
                   
                   
                 GAATGGAATGGACCCAAATGGAATGGAATGGAATGGAATG (SEQ ID NO: 566) 
               
               
                   
               
               
                 561 
                 HGL6.1226 
                   
                 GGAATACAACGGAATGGAATCGAAAAAAATGGAAAGGAATGAAATGAATGGAA 
               
               
                   
                   
                   
                 TGGAATGGAATGGAATGGATGGGAATGGAATGGAATGG (SEQ ID NO: 567) 
               
               
                   
               
               
                 562 
                 HGL6.1227 
                   
                 GAATCAAGCGGAATTATCGAATGGAATCGAAGAGAATCATCGAAAGGACTCGAA 
               
               
                   
                   
                   
                 TGGAATCATCTAATGGAATGGAATGGAATAATACACGGACC (SEQ ID NO: 568) 
               
               
                   
               
               
                 563 
                 HGL6.1232 
                   
                 AACAACAACAACAACAGGAAAACAACCTCAGTATGAAGACAAGTACATTGATTT 
               
               
                   
                   
                   
                 ATTCAACATTTACTGATCACTTTTCAGGTGGTAGGCAGACC (SEQ ID NO: 569) 
               
               
                   
               
               
                 564 
                 HGL6.1233 
                   
                 AAGATAACCTGTGCCCAGGAGAAAAACAATCAATGGCAACAAAAGCAGAAACA 
               
               
                   
                   
                   
                 ACACAAATGATACAATTAGCAGACAGAAACATTGAGATTGCTATT (SEQ ID NO: 
               
               
                   
                   
                   
                 570) 
               
               
                   
               
               
                 565 
                 HGL6.1234 
                   
                 AATGGACTCCAATGGAATAATCATTGAACGGAATCNAATGGAATCATCATCGGA 
               
               
                   
                   
                   
                 TGGAAATGANTGGAATCNTCNTCNAATGGAATCN (SEQ ID NO: 571) 
               
               
                   
               
               
                 566 
                 HGL6.1237 
                   
                 ANNCNNTAAACGTAATCCATCACATAAACANGANCNAANAGNNNAACCGCNNG 
               
               
                   
                   
                   
                 ATTATCTCNNNNNNTGCNNAAAAGGCC (SEQ ID NO: 572) 
               
               
                   
               
               
                 567 
                 HGL6.1240 
                 HGL6.1277 
                 TAATTGATTCGAAATTAATGGAATTGAATGGAATGCAATCAAATGGAATGGAAT 
               
               
                   
                   
                   
                 GTAATGCAATGGAATGTAATAGAATGGAAAGCAATGGAATG (SEQ ID NO: 573) 
               
               
                   
               
               
                 568 
                 HGL6.1242 
                   
                 AAAGGAATGGACTTGAACAAAATGAAATCGAACGATAGGAATCGTACAGAACG 
               
               
                   
                   
                   
                 GAAAGAAATGGAACGGAATGGAATG (SEQ ID NO: 574) 
               
               
                   
               
               
                 569 
                 HGL6.1243 
                   
                 AGCAACTTCAGCAAAATCTCAGGATACAAAATCAATGTACAAAAATCACAAGCA 
               
               
                   
                   
                   
                 TTCTTATACACCAACAACAGACAAACAGAGAGCC (SEQ ID NO: 575) 
               
               
                   
               
               
                 570 
                 HGL6.1247 
                   
                 TGAGCAGGGAACAATGCGGATAAATTTCACAAATACAATGTTGAGCAAAAGAAA 
               
               
                   
                   
                   
                 GACACAAAANAATACACACATACACACCATATGGGCTAGG (SEQ ID NO: 576) 
               
               
                   
               
               
                 571 
                 HGL6.1254 
                   
                 AATGGAATGGAATGTACAAGAAAGGAATGGAATGAAACCGAATGGAATGGAAT 
               
               
                   
                   
                   
                 GGACGCAAAATGAATGGAATGGAAGTCAATGG (SEQ ID NO: 577) 
               
               
                   
               
               
                 572 
                 HGL6.1260 
                   
                 AAGTTCAAACATCAGTATTAACCTTGAACATCAATGGCCTACATGCATCACTTAA 
               
               
                   
                   
                   
                 AACATACAGACAGGCAAATTGGGTTAAGAAAACAAACAAGCAAACAAAACATG 
               
               
                   
                   
                   
                 TTCCAAACATTTGTTGGCTAT (SEQ ID NO: 578) 
               
               
                   
               
               
                 573 
                 HGL6.1262 
                   
                 GGAATAATCATTGAACGGAATCGAATGGAATCATCATCGGATGGAAACGAATGG 
               
               
                   
                   
                   
                 AATCATCATCGAATGGAAATGAAAGGAGTCATC (SEQ ID NO: 579) 
               
               
                   
               
               
                 574 
                 HGL6.1264 
                   
                 GGAACGAAATCGAATGGAACGGAATAGAATAGACTCGAATGTAATGGATTGCTA 
               
               
                   
                   
                   
                 TGTAATTGATTCGAATGGAATGGAATCG (SEQ ID NO: 580) 
               
               
                   
               
               
                 575 
                 HGL6.1265 
                   
                 TGAAAGGAATAGACTGGAACAAAATGAAATCGAATGGTAGGAATCATACAGAA 
               
               
                   
                   
                   
                 CAGAAAGAAATGGAACGGAATGGAATG (SEQ ID NO: 581) 
               
               
                   
               
               
                 576 
                 HGL6.1266 
                   
                 AACCCGAATAGAATGGAATGGAATGGAATGGAACGGAACGGAATGGAATGGAA 
               
               
                   
                   
                   
                 TGGATTGGAATGGAATGGAATG (SEQ ID NO: 582) 
               
               
                   
               
               
                 577 
                 HGL6.1267 
                   
                 AAAGAGAATCAAATGGAATTGAATCGAATGGAATCGAATGGATTGGAAAGGAA 
               
               
                   
                   
                   
                 TAGAATGGAATGGAATGGAATGGAATGGAATGGAATG (SEQ ID NO: 583) 
               
               
                   
               
               
                 578 
                 HGL6.1269 
                   
                 AAAACACACAAACATACATGTGGATGCACATATAAACATGCACATACACACACA 
               
               
                   
                   
                   
                 CATAAATGCACAAACACACTTAACACAAGCACACATGCAAACAAACACATGG 
               
               
                   
                   
                   
                 (SEQ ID NO: 584) 
               
               
                   
               
               
                 579 
                 HGL6.1270 
                   
                 AATGGAATCATCAGTAATGGAATGGAAAGGAATGGAAAGGACTGGAATGGAAT 
               
               
                   
                   
                   
                 GGAATGGAATGGAATGG (SEQ ID NO: 585) 
               
               
                   
               
               
                 580 
                 HGL6.1271 
                   
                 GGAACAAAATGAAATCGAACGGTAGGAATCGTACAGAACGGAAAGAAATGGAA 
               
               
                   
                   
                   
                 CGGAATGGAATGCACTCAAATGGAAAGGAGTCCAATGGAATCGAAAGGAATAG 
               
               
                   
                   
                   
                 AATGGAATGG (SEQ ID NO: 586) 
               
               
                   
               
               
                 581 
                 HGL6.1272 
                   
                 AGAATGAGATCAAGCAGTATAATAAAGGAAGAAGTAGCAAAATTACAACAGAG 
               
               
                   
                   
                   
                 CAGTGAAATGGATATGCTTTCTGGCAATAATTGTGAAAGGTCTGGTAATGAGAA 
               
               
                   
                   
                   
                 AGTAGCAACAGCTAGTGGCTGCCAC (SEQ ID NO: 587) 
               
               
                   
               
               
                 582 
                 HGL6.1273 
                   
                 AACAAATGGAATCAACATCGAATGGAATCGAATGGAAACACCATCGAATTGAAA 
               
               
                   
                   
                   
                 CGAATGGAATTATCATGAAATTGAAATGGATGGACTCATCATCG (SEQ ID NO: 
               
               
                   
                   
                   
                 588) 
               
               
                   
               
               
                 583 
                 HGL6.1278 
                   
                 TAACATGCAGCATGCACACACGAATACACAACACACAAACATGTATGCACGCAC 
               
               
                   
                   
                   
                 ACGTGAATACACAACACACACAAACATGCATGCATGCATACATGAATACACAGC 
               
               
                   
                   
                   
                 ACACAAATATCCAGCAT (SEQ ID NO: 589) 
               
               
                   
               
               
                 584 
                 HGL6.1279 
                   
                 GAATGGAATCAACATCAAACGGAAAAAAAACGGAATTATCGAATGGAATCGAA 
               
               
                   
                   
                   
                 TAGAATCATCGAATGGACC (SEQ ID NO: 590) 
               
               
                   
               
               
                 585 
                 HGL6.1281 
                   
                 AATCGAATGAAATGGAGTCAAAAGGAATGGAATCGAATGGCAAGAAATCGAAT 
               
               
                   
                   
                   
                 GTAATGGAATCGCAAGGAATTGATGTGAACGGAACGGAATGGAAT (SEQ ID NO: 
               
               
                   
                   
                   
                 591) 
               
               
                   
               
               
                 586 
                 HGL6.1282 
                   
                 AATGGAATTGAACGGAAACATCAGCGAATGGAATCGAAAGGAATCATCATGGA 
               
               
                   
                   
                   
                 ATAGATTCGAATGGAATGGAAAGGAATGGAATGGAATG (SEQ ID NO: 592) 
               
               
                   
               
               
                 587 
                 HGL6.1283 
                   
                 ATGGAATCAACATCAAACAGAATCAAACGGAATTATCGAATGGAATCGAAGACA 
               
               
                   
                   
                   
                 ATCATCGAATGGACTCGAATGGAATCATCTAATGGAATGGAATGGAAGAATCCA 
               
               
                   
                   
                   
                 TGGTCTCGAATGCAATCATCATCG (SEQ ID NO: 593) 
               
               
                   
               
               
                 588 
                 HGL6.1284 
                   
                 GAATAATCATTGAACGGAATCGAATGGAATCATCTTCGGATGGAAACGAATGGA 
               
               
                   
                   
                   
                 ATCATCATCGAATGGAAATGAAAGGAGTCATC (SEQ ID NO: 594) 
               
               
                   
               
               
                 589 
                 HGL6.1288 
                   
                 AATGGACTCGAATGGAATAATCATTGAACGGAATCGAATGGAATCATCATCGGA 
               
               
                   
                   
                   
                 TGGAAATGAGTGGAATCATCATCGAATGGAATCG (SEQ ID NO: 595) 
               
               
                   
               
               
                 590 
                 HGL6.1290 
                   
                 AAATGAAATCGAACGGTAGGAATCGTACAGAACGGAAAGAAATGGAACGGAAT 
               
               
                   
                   
                   
                 GGAATGCAATCGAATGGAAAGGAGTCCAATGGAAGGGAATCGAAT (SEQ ID NO: 
               
               
                   
                   
                   
                 596) 
               
               
                   
               
               
                 591 
                 HGL6.1291 
                   
                 TACCAAACATTTAAAGAACAAATATCAATCCTACGCAAACCATTCTGAAACACA 
               
               
                   
                   
                   
                 GAGATGGAGGATATACAGCGAAACTCATTCTACATGGCC (SEQ ID NO: 597) 
               
               
                   
               
               
                 592 
                 HGL6.1292 
                   
                 TATTGGAATGGAATGGAATGGAGTCGAATGGAACGGAATGCACTCGAATGGAAG 
               
               
                   
                   
                   
                 GCAATGCAATGGAATGCACTCAACAGGAATAGAATGGAATGGAATGGAATGG 
               
               
                   
                   
                   
                 (SEQ ID NO: 598) 
               
               
                   
               
               
                 593 
                 HGL6.1294 
                   
                 AGAGAGTATTCATCATGAGGAGTATTACTGGACAAATAATTCACAAACGAACAA 
               
               
                   
                   
                   
                 ACCAAAGCGATCATCTTTGTACTGGCTGGCTA (SEQ ID NO: 599) 
               
               
                   
               
               
                 594 
                 HGL6.1295 
                   
                 GGAATTTAATAGAATGTACCCGAATGGAACGGAATGGAATGGAATTGTATGGCA 
               
               
                   
                   
                   
                 TGGAATGGAA (SEQ ID NO: 600) 
               
               
                   
               
               
                 595 
                 HGL6.1298 
                   
                 GCAATCCANTANAATGGAATCGAATGGCATGGAATATAAAGAAATGGAATCGAA 
               
               
                   
                   
                   
                 GAGAATGGAGACAAATGGAATGGAATTGAATGGAATGGAATTG (SEQ ID NO: 
               
               
                   
                   
                   
                 601) 
               
               
                   
               
               
                 596 
                 HGL6.1299 
                   
                 AATGGAATCGAATGGAATCATCATCAAATGGAATCTAATGGAATCATTGAACGG 
               
               
                   
                   
                   
                 AATTAAATGGAATCGTCATCGAATGAATTCAATGCAATCAACGAATGGTCTCGA 
               
               
                   
                   
                   
                 ATGGAACCAC (SEQ ID NO: 602) 
               
               
                   
               
               
                 597 
                 HGL6.1300 
                   
                 AATTGCAAAAGAAACACACATATACACATATAAAACTCAAGAAAGACAAAACTA 
               
               
                   
                   
                   
                 ACCTATGGTGATAGAAATCAGAAAAGTACAGTACATTGGTTGTCTTGGTGGG 
               
               
                   
                   
                   
                 (SEQ ID NO: 603) 
               
               
                   
               
               
                 598 
                 HGL6.1303 
                   
                 TGACATCATTATTATCAAGAAACATTCTTACCACTGTTACCAACTTCCCAACACA 
               
               
                   
                   
                   
                 GACTATGGAGAGAGAGATAAGACAGAATAGCATT (SEQ ID NO: 604) 
               
               
                   
               
               
                 599 
                 HGL6.1305 
                   
                 GGAATCTATAATACAGCTGTTTATAGCCAAGCACTAAATCATATGATACAGAAA 
               
               
                   
                   
                   
                 ACAAATGCAGATGGTTTGAAGGGTGGG (SEQ ID NO: 605) 
               
               
                   
               
               
                 600 
                 HGL6.1308 
                   
                 AAAGAATTGAATTGAATAGAATCACCAATGAATTGAATCGAATGGAATCGTCAT 
               
               
                   
                   
                   
                 CGAATGGAATCGAAGGGAATCATTGGATGGGCTCA (SEQ ID NO: 606) 
               
               
                   
               
               
                 601 
                 HGL6.1311 
                   
                 ATCATCGAATGGAATCGAATGGAATCAATATCAAACGGAAAAAAACGGAATTAT 
               
               
                   
                   
                   
                 CGAATGGAATCGAATAGAATCATCGAATGGACC (SEQ ID NO: 607) 
               
               
                   
               
               
                 602 
                 HGL6.1314 
                   
                 GAATGAAATCGTATAGAATCATCGAATGCAACTGAATGGAATCATTAAATGGAC 
               
               
                   
                   
                   
                 TTGAAAGGAATTATTATGGAATGGAATTG (SEQ ID NO: 608) 
               
               
                   
               
               
                 603 
                 HGL6.1316 
                   
                 TAAGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGTGCAAAAATCTCAAG 
               
               
                   
                   
                   
                 CATTCTTATACACGAACAACAGACAAACAGAGAGCT (SEQ ID NO: 609) 
               
               
                   
               
               
                 604 
                 HGL6.1317 
                   
                 ACTCAAAAGGAATTGATTCGAATGGAATAGAATGGCAAGGAATAGTATTGAATT 
               
               
                   
                   
                   
                 GAATGGAATGGAATGGACCCAAATG (SEQ ID NO: 610) 
               
               
                   
               
               
                 605 
                 HGL6.1319 
                   
                 GAATGGAATTTAAAGGAATAGAATGGAAGGAATCGGATGGAATGGAATGGAAT 
               
               
                   
                   
                   
                 AGAATGGAGTCGAATGGAATAGAATCGAATGGAATGGCATTG (SEQ ID NO: 611) 
               
               
                   
               
               
                 606 
                 HGL6.1323 
                   
                 AACAAAAAATGAGTCAAGCCTTAAATAAAATCAGAGCCAAAAAAGAAGACATT 
               
               
                   
                   
                   
                 ACATCTGATAAGACAAAAATTCAAAGGACCATC (SEQ ID NO: 612) 
               
               
                   
               
               
                 607 
                 HGL6.1324 
                   
                 AACCCAGTGGAATTGAATTGAATGGAATTGAATGGAATGGAAAGAATCAATCCG 
               
               
                   
                   
                   
                 AGTCGAATGGAATGGTATGGAATGGAATGGCATGGAATCAAC (SEQID NO: 613) 
               
               
                   
               
               
                 608 
                 HGL6.1327 
                   
                 ATCAACATCAAACGGAAAAAAAACGGAATTATCGAATGGAATCGAAGAGAATC 
               
               
                   
                   
                   
                 ATCGAATGGACC (SEQ ID NO: 614) 
               
               
                   
               
               
                 609 
                 HGL6.1331 
                   
                 AAGGAATGGAATGGTACGGAATAGAATGGAATGGAACGAATTGTAATGGAATG 
               
               
                   
                   
                   
                 GAATTTAATGGAACGGAATGGAATGGAATGGAATCAACG (SEQ ID NO: 615) 
               
               
                   
               
               
                 610 
                 HGL6.1334 
                   
                 AACGGAATGGAAAGCAATTTAATCAAATGCAATACAGTGGAATTGAAGGGAATG 
               
               
                   
                   
                   
                 GAATGGAATGGC (SEQ ID NO: 616) 
               
               
                   
               
               
                 611 
                 HGL6.1335 
                   
                 AATCGAATGGAACGGAATAGAATAGACTCGAATGTAATGGATTGCTATGTAATT 
               
               
                   
                   
                   
                 GATTCGAATGGAATGGAATCGAATGGAATGCAATCCAATGGAATGGAATGCAAT 
               
               
                   
                   
                   
                 GCAATGGAATGGAATCGAACGGAATGCAGTGGAAGGGAATGG (SEQ ID NO: 617) 
               
               
                   
               
               
                 612 
                 HGL6.1336 
                   
                 TAGCAACATTTTAGTAACATGATAGAAACAAAACAGCAACATAGCAATGCAATA 
               
               
                   
                   
                   
                 GTAACACAACAGCAACATCATAACATGGCAGCA (SEQ ID NO: 618) 
               
               
                   
               
               
                 613 
                 HGL6.1337 
                   
                 GGACAAATTGCTAGAAATAAACAAATTACCAAAAATGATTCAAGTAGAGACAGA 
               
               
                   
                   
                   
                 GAATCAAAATAGAACTACACATAAGTGGGCCAAG (SEQ ID NO: 619) 
               
               
                   
               
               
                 614 
                 HGL6.1340 
                   
                 AAAATAGAATGAAAGAGAATCAAATGGAATTGAATCGAATGGAATCGAATGGA 
               
               
                   
                   
                   
                 TTGGAAAGGAATAGAATGGAATGGAATGGAATG (SEQ ID NO: 620) 
               
               
                   
               
               
                 615 
                 HGL6.1342 
                   
                 AGCAAACAAGTGAATAAACAAGCAAACAAGTGAACAAGCAAACAAGTGAATAA 
               
               
                   
                   
                   
                 ACAAGCAAACAAGTGAACAAGCAAACAAGTGAATAAACAAGCAAACAAGTGAA 
               
               
                   
                   
                   
                 CAAGGAAACAAGTGAATAAACAAAGGCTCT (SEQ ID NO: 621) 
               
               
                   
               
               
                 616 
                 HGL6.1346 
                   
                 AATGGAATCAACACGAGTGCAATTGAATGGAATCGAATGGAATGGAATGGAATG 
               
               
                   
                   
                   
                 GAATGAATTCAACCCGAATGGAATGGAAAGGAATGGAATC (SEQ ID NO: 622) 
               
               
                   
               
               
                 617 
                 HGL6.1347 
                   
                 AATATACGC   AAATCAATAAATG   TAATCCAGCATATAAACAGTACTAAAGACAAA 
               
               
                   
                   
                   
                 AACCACATGATTATCTCAATAGATGCAGAAAAGGCC (SEQ ID NO: 623) 
               
               
                   
               
               
                 618 
                 HGL6.1352 
                   
                 GAATCGAATGGAATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATC 
               
               
                   
                   
                   
                 GAAGAGNNNNNNCGAATGGACC (SEQ ID NO: 624) 
               
               
                   
               
               
                 619 
                 HGL6.1354 
                   
                 AACACGAATGTAATGCAATCCAATAGAATGGAATCGAATGGCATGGAATATAAA 
               
               
                   
                   
                   
                 GAAATGGAATCGAAGAGAATGGAAACAAACGGAATGGAATTGAATGGAATGGA 
               
               
                   
                   
                   
                 ATTGAATGGAATGGGAACGAATGGAGTGAAATTG (SEQ ID NO: 625) 
               
               
                   
               
               
                 620 
                 HGL6.1355 
                   
                 GAATGGAACGGAATAGAACAGACTCGAATGTAATGGATTGCTATGTAATTGATT 
               
               
                   
                   
                   
                 CGAATGGAATGGAATCGAATGGAATGCAATCCAATGGAATGGAATGCAATGCAA 
               
               
                   
                   
                   
                 TGGAATGGAATCGAATGGAATGCAGTGGAAGGGAATGG (SEQ ID NO: 626) 
               
               
                   
               
               
                 621 
                 HGL6.1356 
                   
                 GAATCGAATGGAATCAATATCAAACGGAAAAAAACGGAATTATCGAATGGAATC 
               
               
                   
                   
                   
                 GAAGAGAATCATCGAATGGACC (SEQ ID NO: 627) 
               
               
                   
               
               
                 622 
                 HGL6.1359 
                   
                 TAAACAACGAGAACACATGAACACAAAGAGGGGAACAACAGACACCAAGACCT 
               
               
                   
                   
                   
                 TCTTGAGGGTGGAGGATGGGAGGAGGGAG (SEQ ID NO: 628) 
               
               
                   
               
               
                 623 
                 HGL6.1360 
                   
                 AGCAACTTCAGCAGTCTCAGTATACAAAAACAATGTGCAAAAATCACAAGCATT 
               
               
                   
                   
                   
                 CCTATATGCCAATAACAGACAAACAGAGAGCC (SEQ ID NO: 629) 
               
               
                   
               
               
                 624 
                 HGL6.1361 
                   
                 ATCAAAAGAAAAGCAACCTAACAAATACGGGAAGAATATTTGAATAGACATTTC 
               
               
                   
                   
                   
                 ACAGGAAAAGATATATGAATGGCCAAAAAGCAAATGAAAAG (SEQ ID NO: 630) 
               
               
                   
               
               
                 625 
                 HGL6.1364 
                   
                 ATAAACATCAAACGGAATCAAACGGAATTATCGAATGGAATCGAAGAGAATAAT 
               
               
                   
                   
                   
                 CGAATGGACTCAAATGGAGTCATCTAATGGAATGGTATGGAAGAATCCATGGAC 
               
               
                   
                   
                   
                 TCCAACGCAATCATCAGCGAATGGAATC (SEQ ID NO: 631) 
               
               
                   
               
               
                 626 
                 HGL6.1365 
                   
                 AAAAGAAAAGACAAAAGACACCAATTGCCAATACTGAAATGAAAAAACAGGTA 
               
               
                   
                   
                   
                 ATAACTATTGATCCCATGGACATTAAAATGATGTTGAAGGAACACCAC (SEQ ID 
               
               
                   
                   
                   
                 NO: 632) 
               
               
                   
               
               
                 627 
                 HGL6.1368 
                   
                 AGCAATAACCAAACAACCTCATTAAAAAGTAGGCAAAGGACATAAACAGACACT 
               
               
                   
                   
                   
                 TTTCAAAAGAAGACATACACGTGGCCAACAAACATATG (SEQ ID NO: 633) 
               
               
                   
               
               
                 628 
                 HGL6.1370 
                   
                 AGCAACTTCAGCAAAGTCTCAGGATACAAAATCGATGTGCAAAAATCACAAGCA 
               
               
                   
                   
                   
                 TTCTTATACACCAATAACAGGCAAACAGAGAGCC (SEQ ID NO: 634) 
               
               
                   
               
               
                 629 
                 HGL6.1371 
                   
                 GTCATATTTGGGATTTATCATCTGTTTCTATTGTTGTTGTTTTAGTACACACAAAG 
               
               
                   
                   
                   
                 CCACAATAAATATTCTAGGCT (SEQ ID NO: 635) 
               
               
                   
               
               
                 630 
                 HGL6.1373 
                   
                 ATCATCGAATGGAATAGAATGGTATCAACATCAAACGGAGAAAAACGGAATTAT 
               
               
                   
                   
                   
                 CGAATGGAATCGAAGAGAATCTTCGAACGGACC (SEQ ID NO: 636) 
               
               
                   
               
               
                 631 
                 HGL6.1374 
                   
                 AAATAAGCCAACGGTCATAAATTGCAAAGCCTTTTACAATCCAAACATGATGGA 
               
               
                   
                   
                   
                 AACGATATGCCATTTTGAAGGTGATTTGAAAAGCACATGGTTT (SEQ ID NO: 637) 
               
               
                   
               
               
                 632 
                 HGL6.1375 
                   
                 GAATGGAATCATCGCATAGAATCGGATGGAATTATCATCGAATGGAATCGAATG 
               
               
                   
                   
                   
                 GTATCAACATCAAACGGAAAAAAACGGAATTATCGAATGGAATCGAATTGAATC 
               
               
                   
                   
                   
                 ATCGAACGGACCCG (SEQ ID NO: 638) 
               
               
                   
               
               
                 633 
                 HGL6.1378 
                   
                 AATGGACTCGAATGGAATAATCATTGAACGGAATCGAATGGAATCATCATCGGA 
               
               
                   
                   
                   
                 TGGAAATGAATGGAATAATCCATGGACTCGAATGCAATCATCATCGAATGGAAT 
               
               
                   
                   
                   
                 CGAATGGAATCATCGAATGGACTCG (SEQ ID NO: 639) 
               
               
                   
               
               
                 634 
                 HGL6.1379 
                   
                 AATGCAATCATCAACTGGCTTCGAATGGAATCATCAAGAATGGAATCGAATGGA 
               
               
                   
                   
                   
                 ATCATCGAATGGACTC (SEQ ID NO: 640) 
               
               
                   
               
               
                 635 
                 HGL6.1380 
                   
                 AAGAGACCAATAAGGANTANGTAAGCAACANGAGGAAGGAGANANGGGCAAG 
               
               
                   
                   
                   
                 AGAGATGACCAGAGTT (SEQ ID NO: 641) 
               
               
                   
               
               
                 636 
                 HGL6.1382 
                   
                 TGGAATCATCATAAAATGGAATCGAATGGAATCAACATCAAATGGAATCAAATG 
               
               
                   
                   
                   
                 GAATCATTGAACGGAATTGAATGGAATCGTCAT (SEQ ID NO: 642) 
               
               
                   
               
               
                 637 
                 HGL6.1383 
                   
                 GGAATCATCGCATAGAATCGAATGGAATTATCATCGAATGGAATCGAATGGAAT 
               
               
                   
                   
                   
                 CAACATCAAACGAAAAAAAACCGGAATTATCGAATGGAATCGAAGAGAATCATC 
               
               
                   
                   
                   
                 GAACGGACC (SEQ ID NO: 643) 
               
               
                   
               
               
                 638 
                 HGL6.1384 
                   
                 AAATCATCATCGAATGGGATCGAATGGTATCCTTGAATGGAATCGAATGGAATC 
               
               
                   
                   
                   
                 ATCATCAGATGGAAATGAATGGAATCGTCAT (SEQ ID NO: 644) 
               
               
                   
               
               
                 639 
                 HGL6.1386 
                   
                 GGAATGTAATAGAACGGAAAGCAATGGAATGGAACGCACTGGATTCGAGTGCA 
               
               
                   
                   
                   
                 ATGGAATCTATTGGAATGGAATCGAATGGAATGGTTTGGCATGGAATGGAC (SEQ 
               
               
                   
                   
                   
                 ID NO: 645) 
               
               
                   
               
            
           
         
       
     
     REFERENCES 
     
         
         1. R. J. Jackson, C. U. T. Hellen, T. V. Pestova,  Nat. Rev. Mol. Cell. Biol.  10, 113 (2010). 
         2. N. Sonenberg, A. G. Hinnebusch,  Cell  136, 731 (2009). 
         3. C. U. T. Hellen, P. Sarnow,  Genes Dev.  15, 1593 (2001). 
         4. S. Vagner, B. Galy, S. Pyronnet,  EMBO Rep.  2, 893 (2001). 
         5. M. Stoneley, A. E. Willis,  Oncogene  23, 3200 (2004). 
         6. J. S. Kieft, A. Grech, P. Adams, J. A. Doudna,  Cold Spring Harbor Symp. on Quant. Biol.  66, 277 (2001). 
         7. N. Malys, J. E. G. McCarthy,  Cell. Mol. Life. Sci.  68, 991 (2011). 
         8. T. A. Hughes,  Trends Genet.  22, 119 (2006). 
         9. X. Qin, P. Sarnow,  J. Biol. Chem.  279, 13721 (2004). 
         10. M. Bushell et al.,  Mol. Cell  23, 401 (2006). 
         11. J. D. Thomas, G. J. Johannes,  RNA  13, 1116 (2007). 
         12. G. Johannes, M. S. Carter, M. B. Eisen, P. O. Brown, P. Sarnow,  Proc. Natl. Acad. Sci. USA  96, 13118 (1999). 
         13. S. Braunstein et al.,  Mol. Cell.  28, 501 (2007). 
         14. K. A. Spriggs, M. Stoneley, M. Bushell, A. E. Willis,  Biol. Cell  100, 27 (2008). 
         15. S. D. Baird, M. Turcotte, R. G. Korneluk, M. Holcik,  RNA  12, 1755 (2006). 
         16. R. W. Roberts, J. W. Szostak,  Proc. Natl. Acad. Sci. USA  94, 12297 (1997). 
         17. T. T. Takahashi, R. J. Austin, R. W. Roberts,  Trends Biochem. Sci.  28, 159 (2003). 
         18. W. J. Kent,  Genome Res.  12, 656 (2002). 
         19. J. O. Korbel et al.,  Science  318, 420 (2007). 
         20. M. Kasowski et al.,  Science  328, 232 (2010). 
         21. K. Salehi-Ashtiani, A. Luptak, A. Litovchick, J. W. Szostak,  Science  313, 1788 (2006). 
         22. E. S. Lander et al.,  Nature  409, 860 (2001). 
         23. R. Cordaux, M. A. Batzer,  Nat. Rev. Genet.  10, 691 (2009). 
         24. B. T. Baranick et al.,  Proc. Natl. Acad. Sci. USA  105, 4733 (2008). 
         25. T. R. Fuerst, E. G. Niles, F. W. Studier, B. Moss,  Proc. Natl. Acad. Sci. USA  83, 8122 (1986). 
         26. W. V. Gilbert, K. H. Zhou, T. K. Butler, J. A. Doudna,  Science  317, 1224 (2007). 
         27. M. Kozak,  Nuc. Acids Res.  15, 8125 (1987). 
         28. Q. Yang, P. Sarnow,  Nuc. Acids Res.  25, 2800 (1997). 
         29. I. Huez et al.,  Mol. Cell. Biol.  18, 6178 (1998).