Patent Publication Number: US-8986958-B2

Title: Methods for generating target specific probes for solution based capture

Description:
This application claims the filing date benefit of U.S. Provisional Application No. 61/164,859, filed on Mar. 30, 2009. The contents of each foregoing patent applications are incorporated by reference in their entirety. 
     Throughout this application various publications are referenced. The disclosures of these publications in their entireties are hereby incorporated by reference into this application in order to more fully describe the state of the art to which this invention pertains. 
    
    
     FIELD 
     The present invention relates generally to the field of genomic analysis, and more particularly, to methods and kits for making libraries of single-stranded nucleic acid probes comprising predetermined sequences. 
     BACKGROUND 
     The ability to sequence deoxyribonucleic acid (DNA) accurately and rapidly is revolutionizing biology and medicine. The pharmacogenomics challenge is to comprehensively identify the genes and functional polymorphisms associated with the variability in drug response. Screens for numerous genetic markers performed for populations large enough to yield statistically significant data are needed before associations can be made between a given genotype and a particular disease. 
     The study of complex genomes, and in particular, the search for the genetic basis of disease in humans, requires genotyping on a massive scale, which is demanding in terms of cost, time, and labor. Such costly demands are even greater when the methodology employed involves serial analysis of individual DNA samples, i.e., separate reactions for individual samples. Resequencing of polymorphic areas in the genome that are linked to disease development will contribute greatly to the understanding of diseases, such as cancer, and therapeutic development. Oligonucleotide libraries are the cornerstone of sequence-based gene resequencing and digital profiling strategies. To realize the full commercial potential of various high-throughput sequencing platforms, the cost of generating oligonucleotide libraries must be reduced by a substantial amount. Thus, there is a need for cost-effective methods for preparing populations of high quality oligonucleotide probes with sufficient yield for use in high throughput sequencing platforms and solution based capture methods. 
     SUMMARY 
     Provided herein are methods for generating a population of single-stranded nucleic acid probes, each probe comprising a predetermined nucleotide sequence, the method comprising: (a) providing a starting population of linear double-stranded nucleic acid precursor molecules each precursor molecule having (i) a probe region having the predetermined sequence which is flanked at a 5′ and a 3′ end by a first and a second restriction enzyme recognition sequence for generating ligation substrates and for ligating a plurality of the double-stranded nucleic acid precursor molecules into head-to-tail concatemers (ii) the 5′ flanking region including the first restriction enzyme recognition sequence and (iii) the 3′ flanking region including the second restriction enzyme recognition sequence; (b) contacting the 5′ and 3′ flanking regions of the linear double-stranded nucleic acid precursor molecules with the first and second restriction enzymes to cleave the first and second restriction enzyme recognition sequences so as to generate the ligation substrates; (c) ligating the ligation substrates together so as to generate a plurality of random head-to-tail concatemers; (d) amplifying the plurality of head-to-tail concatemers; (e) contacting the amplified head-to-tail concatemers with the first and second restriction enzymes so as to release a plurality double-stranded monomer linear precursor molecules; and (f) selectively removing one strand of the double-stranded monomer linear precursor molecules so as to generate a population of single-stranded nucleic acid probes, each probe comprising the predetermined nucleotide sequence. 
     In one embodiment, the single-stranded nucleic acid probes further comprise a region which hybridizes to a capture nucleic acid molecule. 
     In yet another embodiment, the selectively removing one strand from the double-stranded monomer linear precursor molecules comprises: (a) contacting the released precursor molecules of step (e) above with alkaline phosphatase; (b) contacting the released precursor molecules of step (e) above with a third restriction enzyme which cleaves the third restriction enzyme recognition sequence; and (c) contacting the released precursor molecules of step (e) above with an exonuclease so as to selectively degrade the one strand of the double-stranded monomer linear precursor molecules. 
     In one embodiment, the exonuclease is lambda exonuclease. 
     In another embodiment, the members of the starting population of the linear double-stranded nucleic acid precursor molecules each comprise the same nucleotide sequence in the 5′ flanking region or each comprise the same nucleotide sequence in the 3′ flanking region. 
     In another embodiment, the 3′ flanking region further comprises a third restriction enzyme recognition sequence. 
     In another embodiment, the members of the starting population of the linear double-stranded nucleic acid precursor molecules each comprise the same predetermined sequences or different predetermined sequences. 
     In another embodiment, the ligation substrates of step (b) comprise overhanging nucleic acid ends capable of annealing together. 
     In another embodiment, the first or second restriction enzyme recognition sequence is cleaved by a type II restriction enzyme. 
     In another embodiment, the first or second restriction enzyme recognition sequence is cleaved by a Bsm1 enzyme. 
     In another embodiment, each predetermined nucleotide sequence in the population of linear double-stranded nucleic acid precursor molecules comprise a nucleotide sequence which is at least 95% identical to at least a portion of a sense or anti-sense strand of a target nucleic acid sequence. 
     In another embodiment, the predetermined sequence hybridizes to one target sequence or hybridizes to different target sequences. 
     In another embodiment, the predetermined sequences in the population of linear double-stranded nucleic acid precursor molecules hybridize to at least 10 different exon nucleotide sequences. 
     In another embodiment, the predetermined sequences in the population of linear double-stranded nucleic acid precursor molecules hybridize to at least 1000 different exon nucleotide sequences. 
     In another embodiment, the predetermined sequences hybridize to the target sequence at an interval of at least every 35 bases across the target sequence. 
     In another embodiment, the predetermined sequences hybridize to the target sequence of interest at an interval of one base across the target sequence. 
     In another embodiment, the probe region comprises 20-200 nucleotides. 
     In another embodiment, the predetermined nucleotide sequence comprises 10-50 nucleotides. 
     In another embodiment, the region of the single-stranded nucleic acid probe which hybridizes to the capture nucleic acid molecule comprises 10-50 nucleotides. 
     In another embodiment, the amplifying according to step (d) comprises isothermal amplification. 
     In another embodiment, the amplifying according to step (d) comprises random amplification primers. 
     In another embodiment, the random amplification primers each comprise a random 7-mer oligonucleotide and two additional nitroindole residues at the 5′ end. 
     In another embodiment, the random amplification primers each comprise a random 7-mer oligonucleotide and a phosphorothioate linkage to the 3′ end. 
     In another embodiment, the capture nucleic acid molecule further comprises a protein binding partner. 
     In another embodiment, the protein binding partner is biotin. 
     In another embodiment, each single-stranded nucleic acid probe comprises (i) the predetermined nucleotide sequence having a nucleotide sequence which is at least 95% identical to at least a portion of a sense or an anti-sense strand of a target nucleic acid sequence and (ii) a region which hybridizes to a capture nucleic acid molecule. 
     Provided herein are also a population of single-stranded nucleic acid probes generated by the disclosed methods. 
     Provided herein are also methods, wherein the starting population of linear double-stranded nucleic acid precursor molecules is generated by steps comprising: (a) providing a population of a first single-stranded nucleic acid molecule comprising the 5′ flanking region, the probe region which comprises the predetermined sequence, and the capture sequence; (b) providing a population of a second single-stranded nucleic acid molecules comprising the sequence which is complementary to the capture sequence, and the 3′ flanking region; (c) annealing the first and second populations of the single-stranded nucleic acid molecules to form a nucleic acid duplex having overhanging 5′ ends; and (d) conducting a polymerase-dependent strand extension reaction on the overhanging 5′ ends so as to generate the population of double-stranded nucleic acid precursor molecules. 
     Provided herein are also, methods for enriching a target nucleic acid sequence of interest from a nucleic acid library, comprising: (a) contacting the population of single-stranded nucleic acid probes of the method above with the nucleic acid library having at least one target nucleic acid sequence of interest to form a mixture having unhybridized nucleic acid sequences and duplexes, each duplex having the single-stranded nucleic acid probe hybridized to the target nucleic acid sequence of interest; (b) contacting the duplexes with a population of capture nucleic acid molecules to form complexes having the single-stranded nucleic acid probe hybridized to the target nucleic acid sequence of interest and hybridized to the capture nucleic acid molecule; (c) separating the complex from the mixture; and (d) eluting the target nucleic acid sequence of interest from the complex. 
    
    
     
       DESCRIPTION OF THE DRAWINGS 
         FIG. 1A  illustrates a population of target capture probes ( 200 ) for solution-based capture, designed to provide low density coverage of a target exon ( 10 ), as described in Example 1; 
         FIG. 1B  illustrates a population of target capture probes ( 200 ) for solution-based capture, designed to provide high density coverage of a target exon ( 10 ), as described in Example 1; 
         FIG. 1C  is a schematic diagram of a representative target capture probe ( 200 ) comprising a target-specific binding region ( 202 ) bound to a nucleic acid target ( 10 ), and a region for binding to a capture reagent ( 204 ) bound to a universal adaptor oligonucleotide ( 300 ) comprising a moiety ( 310 ) that binds to a capture reagent; 
         FIG. 2  illustrates a method of enriching a population of DNA molecules for target regions of interest using capture probes ( 200 ) generated in accordance with an embodiment of the present invention; 
         FIG. 3  is a flow chart of the steps of a method for generating a population of capture probes in accordance with various embodiments of the present invention; 
         FIG. 4  (SEQ ID NOS: 69 and 70) illustrates a method of generating a population of single-stranded capture probes ( 200 ) in accordance with an embodiment of the present invention; 
         FIG. 5  illustrates more detail of the method illustrated in  FIG. 4 ; and 
         FIG. 6  graphically illustrates the fold enrichment obtained using capture probes generated in accordance with the methods of the present invention, as described in Example 2. 
     
    
    
     DETAILED DESCRIPTION 
     Unless defined otherwise, all technical and scientific terms used herein have the same meaning as is commonly understood by one of ordinary skill in the art to which these inventions belong. All patents, patent applications, published applications, treatises and other publications referred to herein, both supra and infra, are incorporated by reference in their entirety. If a definition and/or description is explicitly or implicitly set forth herein that is contrary to or otherwise inconsistent with any definition set forth in the patents, patent applications, published applications, and other publications that are herein incorporated by reference, the definition and/or description set forth herein prevails over the definition that is incorporated by reference. 
     The practice of the present disclosure will employ, unless otherwise indicated, conventional techniques of molecular biology, microbiology and recombinant DNA techniques, which are within the skill of the art. Such techniques are explained fully in the literature. See, for example, Sambrook, J., and Russell, D. W., 2001, Molecular Cloning: A Laboratory Manual, Third Edition; Ausubel, F. M., et al., eds., 2002, Short Protocols in Molecular Biology, Fifth Edition. 
     As used herein, the terms “comprising” (and any form or variant of comprising, such as “comprise” and “comprises”), “having” (and any form or variant of having, such as “have” and “has”), “including” (and any form or variant of including, such as “includes” and “include”), or “containing” (and any form or variant of containing, such as “contains” and “contain”), are inclusive or open-ended and do not exclude additional, unrecited additives, components, integers, elements or method steps. 
     As used herein, the terms “a,” “an,” and “the” and similar referents used herein are to be construed to cover both the singular and the plural unless their usage in context indicates otherwise. Accordingly, the use of the word “a” or “an” when used in the claims or specification, including when used in conjunction with the term “comprising”, may mean “one,” but it is also consistent with the meaning of “one or more,” “at least one,” and “one or more than one.” 
     As used herein, the term “nucleic acid molecule” and its variants encompasses both deoxyribonucleotides and ribonucleotides and refers to a polymeric form of nucleotides including two or more nucleotide monomers. The nucleotides can be naturally occurring, artificial, and/or modified nucleotides. 
     As used herein, an “isolated nucleic acid” and its variants is a nucleic acid molecule that exists in a physical form that is non-identical to any nucleic acid molecule of identical sequence as found in nature; “isolated” does not require, although it does not prohibit, that the nucleic acid so described has itself been physically removed from its native environment. For example, a nucleic acid can be said to be “isolated” when it includes nucleotides and/or internucleoside bonds not found in nature. When, instead, composed of natural nucleosides in phosphodiester linkage, a nucleic acid can be said to be “isolated” when it exists at a purity not found in nature, where purity can be adjudged with respect to the presence of nucleic acids of other sequences, with respect to the presence of proteins, with respect to the presence of lipids, or with respect to the presence of any other component of a biological cell, or when the nucleic acid lacks a sequence that flanks an otherwise identical sequence in an organism&#39;s genome, or when the nucleic acid possesses a sequence not identically present in nature. As so defined, “isolated nucleic acid” includes nucleic acids integrated into a host cell chromosome at a heterologous site, recombinant fusions of a native fragment to a heterologous sequence, recombinant vectors present as episomes, or as integrated into a host cell chromosome. 
     As used herein, “subject” and its variants refers to an organism or to a cell sample, tissue sample, or organ sample derived therefrom, including, for example, cultured cell lines, biopsy, blood sample, or fluid sample containing a cell. For example, an organism may be an animal, including but not limited to, an animal such as a cow, a pig, a mouse, a rat, a chicken, a cat, a dog, etc., and is usually a mammal, such as a human. 
     As used herein, the term “specifically bind” and its variants refers to two components (e.g., target-specific binding region and target) that are bound (e.g., hybridized, annealed, complexed) to one another sufficiently that the intended capture and enrichment steps can be conducted. As used herein, the term “specific” refers to the selective binding of two components (e.g., target-specific binding region and target) and not generally to other components unintended for binding to the subject components. 
     As used herein, the term “high stringency hybridization conditions” and its variants means any condition in which hybridization will occur when there is at least 95%, preferably about 97% to 100% nucleotide complementarity (identity) between the nucleic acid sequences of the nucleic acid molecule and its binding partner. However, depending upon the desired purpose, the hybridization conditions may be “medium stringency hybridization,” which can be selected that require less complementarity, such as from about 50% to about 90% (e.g., 60%, 70%, 80%, 85%). The comparison of sequences and determination of percent identity between two sequences can be accomplished using a mathematical algorithm of Karlin and Altschul (Proc. Natl. Acad. Sci. USA 87:2264-2268 (1990)), modified as in Karlin and Altschul (Proc. Natl. Acad. Sci. USA 90:5873-5877 (1993)). Such an algorithm is incorporated into the NBLAST and XBLAST programs of Altschul et al. (J. Mol. Biol. 215:403-410 (1990)). 
     As used herein, the term “complementary” and its variants refers to nucleic acid sequences that are capable of base-pairing according to the standard Watson-Crick complementary rules. That is, the larger purines will base pair with the smaller pyrimidines to form combinations of guanine paired with cytosine (G:C) and adenine paired with either thymine (A:T) in the case of DNA, or adenine paired with uracil (A:U) in the case of RNA. 
     As used herein, the term “target” and its variants refers to a nucleic acid molecule or polynucleotide whose presence and/or amount and/or sequence is desired to be determined and which has an affinity for a given target capture probe. Examples of targets include regions of genomic DNA, PCR amplified products derived from RNA or DNA, DNA derived from RNA or DNA, ESTs, cDNA, and mutations, variants or modifications thereof. 
     As used herein, the term “predetermined nucleic acid sequence” and its variants means that the nucleic acid sequence of a nucleic acid probe is known and was chosen before synthesis of the nucleic acid molecule in accordance with the invention disclosed herein. 
     As used herein, the term “essentially identical” and its variants as applied to synthesized and/or amplified nucleic acid molecules refers to nucleic acid molecules that are designed to have identical nucleic acid sequences, but that may occasionally contain minor sequence variations in comparison to a desired sequence due to base changes introduced during the nucleic acid molecule synthesis process, amplification process, or due to other processes in the method. As used herein, essentially identical nucleic acid molecules are at least 95% identical to the desired sequence, such as at least 96%, such as at least 97%, such as at least 98%, such as at least 99% identical, or absolutely identical, to the desired sequence. 
     As used herein, the term “resequencing” and its variants refers to a technique that determines the sequence of a genome of an organism using a reference sequence that has already been determined. It should be understood that resequencing may be performed on both the entire genome/transcriptome of an organism or a portion of the genome/transcriptome large enough to include the genetic change of the organism as a result of selection. Resequencing may be carried out using various sequencing methods, such as any sequencing platform amenable to producing DNA sequencing reads that can be aligned back to a reference genome, and is typically based on highly parallel technologies such as, for example, dideoxy “Sanger” sequencing, pyrosequencing on beads (e.g., as described in U.S. Pat. No. 7,211,390, assigned to 454 Life Sciences Corporation, Branford, Conn.), ligation based sequencing on beads (e.g., Applied Biosystems Inc,/Invitrogen), sequencing on glass slides (e.g., Illumina Genome Analyzer System, based on technology described in WO 98/44151 (Mayer, P., and Farinelli, L.), microarrays, or fluorescently labeled micro-beads. 
     As used herein, the term “target nucleotide” and its variants refers to a nucleic acid molecule or polynucleotide in a starting population of nucleic acid molecules having a target sequence whose presence and/or amount and/or nucleotide sequence is desired to be determined and which has an affinity for a given target capture probe. 
     As used herein, the term “target sequence” and its variants refers generally to a nucleic acid sequence on a single strand of nucleic acid. The target sequence may be a portion of a gene, a regulatory sequence, genomic DNA, cDNA, RNA including mRNA and rRNA, or others. The target sequence may be a target sequence from a sample, or a secondary target such as a product of an amplification reaction. 
     As used herein, the term “processing” and its variants refers generally to a manipulation of a precursor nucleic acid substrate into a processed form of the substrate, such as by cleavage with a restriction endonuclease, modification and/or amplification with DNA polymerases, manipulation of DNA termini (e.g., by adding terminal 5′ phosphates with a polynucleotide kinase or removing 5′ terminal phosphates with a suitable phosphatase), degradation of unwanted DNA strands with exonuclease, and the like. 
     As used herein, the term “head to tail concatemer” and its variants refers to at least two or more monomeric structures each having a first end and a second end, such as double-stranded nucleic acid molecules, covalently joined in the configuration of the second end of the first monomer joined to the first end of the second monomer. 
     Other objects, features and advantages of the disclosed compositions, methods, systems and kits will become apparent from the following detailed description. It should be understood, however, that the detailed description and the specific examples, while indicating specific embodiments, are given by way of illustration only, since various changes and modifications within the spirit and scope of the inventions provided herein will become apparent to those skilled in the art from this detailed description. 
     Provided herein are compositions, systems, methods and kits for generating a population of single-stranded nucleic acid probes, each probe comprising a predetermined nucleic acid sequence. The methods of the invention are useful in any situation in which it is desirable to make populations of single-stranded nucleic acid molecules (hundreds to thousands, to tens of thousands, to hundreds of thousands, to millions of oligonucleotides), wherein each nucleic acid molecule has a predetermined nucleic acid sequence. For example, the methods may be used to generate a high quantity of a complex population (e.g., library) of single-stranded nucleic acid probes, while maintaining a uniform representation of the individual nucleic acid probes within the population. The applications for pools of oligonucleotides include, but are not limited to, using the oligonucleotides to generate primers for PCR amplification, primers for multiplexing PCR and transcription, probes for SNP (single nucleotide polymorphism) detection, and libraries of nucleic acid probes for genomic analysis, RNA expression analysis, including siRNA and shRNA expression analysis. In some embodiments, the methods according to this aspect of the invention are used to generate a library of target specific probes for solution based capture methods, as described in Examples 1-3 herein. 
     The methods according to this aspect of the invention comprise (a) providing a starting population of double-stranded nucleic acid precursor molecules, wherein each precursor molecule in the starting population comprises a probe region comprising a predetermined sequence that is flanked on the 5′ end by a 5′ flanking region comprising a first processing site and is flanked on the 3′ end by a 3′ flanking region comprising a second processing site, wherein the first and second processing sites are selected to generate ligation substrates for ligation of a plurality of the double-stranded nucleic acid precursor molecules into head-to-tail concatemers; (b) processing the 5′ and 3′ flanking regions of the double-stranded nucleic acid precursor molecules to generate ligation substrates; (c) ligating the ligation substrates together to generate head-to-tail concatemers; (d) amplifying the head-to-tail concatemers; (e) processing the amplified head-to-tail concatemers to release double-stranded monomer precursor molecules; and (f) selectively removing the complement strand of the double-stranded monomer precursor molecules to generate a population of single-stranded nucleic acid probes each probe a predetermined nucleic acid sequence. 
     In one embodiment of the method, a population of target specific capture probes (e.g., a library of capture probes) is generated that may be used in solution based capture methods for enriching a population of DNA molecules for one or more target sequences of interest, such as for resequencing analysis. In accordance with this embodiment, each single-stranded capture probe oligonucleotide in the population of capture probes comprises (i) a target-specific binding region consisting of a nucleic acid sequence that is at least 95% identical to at least a portion of the sense or antisense strand of a target nucleic acid sequence of interest, and (ii) a region for binding to a capture reagent. The methods according to this embodiment of the invention can be used to create populations of single-stranded capture nucleic acid molecules (i.e., capture probes). A population of capture probes is also referred to as a “library” of capture probes. The capture probes generated using the methods described herein may be used for solution based capture to enrich for targets of interest. 
       FIG. 1C  illustrates a representative capture probe  200  comprising a target-specific binding region  202  and a region  204  for binding to a capture reagent  300 . In the embodiment shown in  FIG. 1C , the capture reagent  300  is a universal adaptor oligonucleotide comprising a moiety  310  that binds to a capture reagent. The capture probes  200  generated using the methods of the present invention may be used to enrich a library for target nucleic acid regions of interest in a method referred to as solution based capture. 
     A representative method of solution based capture is illustrated in  FIG. 2 . The capture probes  200  (the capture probe  200  is representative of a population of capture probes) illustrated in  FIG. 2  comprise a target-sequence specific binding region  202  and a capture reagent binding region  204  that hybridizes to a universal adaptor oligonucleotide  300  comprising a moiety  310  that binds to a capture reagent  400 . As shown in  FIG. 2  at step A, in one embodiment, solution based capture comprises contacting a library of DNA molecules  50  comprising a subpopulation of nucleic acid target insert sequences of interest  10  flanked by a first primer binding region  22  and a second primer binding region  32 . The plurality of nucleic acid insert regions in the library include one or more target sequences  10 , and can include enough different nucleic acid sequences to cover (i.e., represent) part or all of a source nucleic acid including, without limitation, the genome of an organism, a genomic locus, a cDNA library, a whole transcriptome of an organism, the exome of an organism and the like. As used herein the term “exome” refers to protein coding regions, promoters, known ncRNAs (non-coding RNAs) and UTRs, altogether comprising about 2% of the human genome. 
     As shown in  FIG. 2  at step B, the target-specific binding region  202  of the target capture probe  200  binds to a substantially complementary target nucleic acid sequence  10 , shown as an insert region  10  of a nucleic acid molecule  50  in a library of nucleic acid molecules. The universal adaptor oligonucleotide  300  is present at an equal concentration as the capture probes  200 , and hybridizes to the capture reagent binding region  204 . The moiety  310  (e.g., biotin) attached to the universal oligo adaptor  300  is then contacted with a capture reagent  400  (e.g., a magnetic bead) having a binding region  410  (e.g., streptavidin coating) and the complex is pulled out of solution with a sorting device  500  (e.g., a magnet) that binds to the capture reagent  400 . 
     Any library of DNA molecules comprising a subpopulation of nucleic acid target insert sequences of interest may be enriched using the solution based capture methods described herein. In some embodiments, the library of DNA molecules comprises a plurality of distinct insert sequences flanked by a first primer binding region and a second primer binding region within a larger population of nucleic acid insert sequences flanked by the first primer binding region and the second primer binding region may be enriched for target sequences using the capture probes  200  generated using the methods disclosed herein. For example, a library of DNA molecules comprising a subpopulation of nucleic acid target insert sequences of interest flanked by a first primer binding region and a second primer binding region within a larger population of nucleic acid insert sequences flanked by the first primer binding region and the second primer binding region may be enriched using the capture probes generated using the methods of the invention. In some embodiments, the library of DNA molecules further comprises at least one anchor probe binding site, such as a flow cell binding site for binding to a flow cell sequencing platform, such as an Illumina Genome Analyzer for sequence analysis. 
     The use of solution-based capture to enrich a library allows for the efficient creation of resequencing samples (sequence-ready libraries) that are largely composed of target sequences, as demonstrated in Example 2. 
     The Design of the Target Capture Probe  200   
     The general design of the target capture probe  200  is described as follows. As shown in  FIG. 1C , the target capture probe  200  comprises a target sequence-specific binding region  202  and a capture reagent region  204  for binding to a capture reagent  300 . 
     The length of a target capture probe  200  is typically in the range of from 20 nucleotides to about 200 nucleotides, such as from about 20 nucleotides to about 150 nucleotides, such as from about 30 nucleotides to about 100 nucleotides, or such as from about 40 nucleotides to about 80 nucleotides. 
     The target-specific binding region  202  of the target capture probe  200  is typically from about 10 to about 150 nucleotides in length (e.g., 35 nucleotides, 50 nucleotides, 100 nucleotides) and is chosen to specifically hybridize to a target sequence of interest. In one embodiment, the target capture probe is about 60 to 80 nucleotides in length, comprising a target-specific binding region of about 20 to 40 nucleotides in length, such as about 35 nucleotides in length. 
     The target specific binding region  202  comprises a sequence that is substantially complementary (i.e., at least 95% identical, at least 96% identical, at least 97% identical, at least 98% identical, at least 99% identical, or 100% identical) to the target sequence of interest. Described in another way, for a target specific binding region  202  having a sequence with a length of from 10 to 100 nucleotides that is at least 95% complementary or at least 95% identical to a target sequence of interest, a region  202  that is from 20 nt to 35 nt in length may contain 1 mismatch, a region  202  that is from 40 nt to 50 nt in length may contain up to 2 mismatches, a region  202  that is from 60 nt to 70 nt may contain up to 3 mismatches, a region  202  that is from 80 nt to 90 nt may contain up to 4 mismatches, and a region  202  having a length of 100 nt may contain up to 5 mismatches with the target sequence. 
     In one embodiment, the method is used to generate a plurality of capture probes  200  each comprise a target-specific binding region  202  consisting of a sequence with a length of 35 nucleotides, that is at least 95% complementary, or at least 95% identical to a target sequence of interest (i.e., up to 1 mismatch with the target sequence). 
     The capture oligonucleotides may be designed to bind to a target region at selected positions spaced across the target region at various intervals. The capture oligo design and target selection process may also take into account genomic features of the target region such as genetic variation, G:C content, predicted oligo Tm, and the like. One of skill in the art can use art-recognized methods to determine the features of a target binding region that will hybridize to the target with minimal non-specific hybridization. For example, one of skill can determine experimentally the features such as length, base composition, and degree of complementarity that will enable a nucleic acid molecule (e.g., the target-specific binding region of a target capture probe) to specifically hybridize to another nucleic acid molecule (e.g., the nucleic acid target) under conditions of selected stringency, while minimizing non-specific hybridization to other substances or molecules. For example, for an exon target of interest, a target gene sequence is retrieved from a public database such as GenBank, and the sequence is searched for stretches of from 25 to 150 bp with a complementary sequence having a GC content in the range of 45% to 55%. The identified sequence may also be scanned to ensure the absence of potential secondary structure and may also be searched against a public database (e.g., a BLAST search) to ensure a lack of complementarity to other genes, as described in Example 3. 
     In some embodiments of the method, a set of capture probes (e.g., a library) is designed to specifically bind to target sequences across a genomic location, such as across a chromosomal region, and the capture probes are contacted with nucleic acid molecules from a total genomic library, or a whole-transcriptome library in order to analyze the whole transcriptome across the chosen genomic locus. In some embodiments of the method, a set of capture probes is designed to specifically bind to a plurality of target regions, such as the exons of a single gene, or multiple genes, such as at least 5 genes, at least 10 genes, at least 20 genes, at least 50 genes, at least 75 genes, at least 200 genes, at least 1000 genes, at least 10,000 genes, or more, as described in Examples 1-3. For example, as demonstrated in Example 3 herein, the methods according to this aspect of the invention were used to generate a set of capture probes comprising 1,148,286 distinct target-specific 35mer regions that were designed to capture all the exons from a total of 25,341 annotated genes from a sample containing nucleic acid sequences derived from a human. 
     In some embodiments of the method, a set of capture probes is designed to specifically bind to a genomic locus known to be associated with a clinical outcome or disease, or disease risk. 
     In some embodiments, the methods of the invention are used to capture and sequence a modified or mutated target, such as to determine the presence of a particular single nucleotide polymorphism (SNP), or deletion, addition, or other modification. In accordance with such embodiments, the set of target capture probes are typically designed such that there is a very dense array of capture probes that are closely spaced together such that a single target sequence, which may contain a mutation, will be bound by multiple capture probes that overlap the target sequence. For example, capture probes may be designed that cover every base of a target region, on one or both strands, (e.g., head to tail), or that are spaced at intervals of every 2, 3, 4, 5, 10, 15, 20, 40, 50, 90, 100, or more bases across a sequence region. 
     As another example, the selection of the target capture probes over a target region of interest is based on the size of the target region. For example, for a target region of less than 100 nucleotides in length, capture probes (either sense, antisense, or both) are typically designed to hybridize to target sequences spaced apart by from 0 to 100 nucleotides, such as every 45 nucleotides, or every 35 nucleotides. As another example, for a target region greater than 200 nucleotides, capture probes (either sense, antisense, or both) are typically designed to hybridize to target sequences spaced apart by from 0 to 200 nucleotides, such as at 45 to 65 nucleotide intervals, or at higher density coverage such as every 35 nucleotide intervals. In one embodiment, for a target region greater than 200 nucleotides (e.g., a 200,000-nucleotide target region), a set of sense and antisense capture probes are designed that are each about 35 nucleotides in length and are spaced about 45 nucleotides apart across the target region (alternating sense/antisense) in order to saturate the region (e.g., “tile” across the region of interest). 
     In one embodiment, a library of target specific probes are designed to bind to a desired target with high density coverage, such that at least one capture probe binds to at least every 35 nucleotide region of the target sequence. In one embodiment, a library of target specific probes are designed to bind to every nucleotide of the target, with alternating binding regions on the sense and antisense strands of the target sequence. 
     Referring now to  FIG. 1C , in one embodiment, the target capture probes  200  each comprise a capture reagent binding region  204  that hybridizes to a universal adaptor oligonucleotide  300  comprising a moiety  310  that binds to a capture reagent  400 . The capture reagent binding region  204  of the target capture probe  200  is typically from about 10 to about 50 nucleotides in length (e.g., 10 nucleotides, 15 nucleotides, 20 nucleotides, 35 nucleotides) and is chosen to specifically hybridize to a universal adaptor oligonucleotide comprising a moiety  310  that binds to a capture reagent. In one embodiment, the target capture probe is about 60 to 80 nucleotides in length, comprising a capture reagent binding region of about 10 to 40 nucleotides in length, such as about 35 nucleotides in length. 
     In operation, as shown in  FIG. 2 , the target-specific binding region  202  of the target capture probes bind to a complementary or substantially complementary nucleic acid sequence contained in a nucleic acid target  10  (i.e., an insert of a nucleic acid molecule in a library, or a genomic region of nucleic acids isolated from a sample). A universal adaptor oligonucleotide  300  is present at an equal concentration as the capture probes  200 , and hybridizes to the capture reagent binding region  204 . The moiety  310  (e.g., biotin) attached to the universal adaptor oligonucleotide  300  is then contacted with a capture reagent  400  (e.g., a magnetic bead) having a binding region  410  (e.g., streptavidin coating) and the complex is pulled out of solution with a sorting device  500  (e.g., a magnet) that binds to the capture reagent  400 . 
     As shown in  FIG. 3 , the method  600  of generating a population of target-specific capture probes in accordance with one embodiment of the invention, includes the step  610  of providing a starting population of double-stranded capture probe precursors, each precursor comprising a capture probe region  200  (comprising a target-sequence specific binding region  202  and a capture reagent binding region  204 ), flanked by a 5′ flanking region  210  and a 3′ flanking region  220 . The 5′ flanking region  210  comprises a first processing site and the 3′ flanking region  220  comprises a second processing site, wherein the first and second processing sites are selected to generate ligation substrates capable of ligation into head-to-tail concatemers. An exemplary double-stranded capture probe precursor  230  is illustrated in  FIG. 4  at step A. As shown in  FIG. 4  at step A, the exemplary double-stranded capture probe precursor  230  comprises a capture probe region  200  flanked on the 5′ end by flanking region  210  comprising a first processing site (e.g., a first Bsm1 site) and is flanked on the 3′ end by flanking region  220  comprising a second processing site (e.g., a second Bsm1 site). In some embodiments, the 3′ flanking region  220  further comprises a third processing site (e.g., a Psi1 site or a HindIII site) selected to precisely cleave off the 3′ flanking region. 
     The 5′ flanking region  210  is typically from about 4 to about 30 nucleotides in length, such as from about 5 to about 15 nucleotides in length, or from about 5 to 10 nucleotides in length. The nucleotide sequence of the 5′ flanking region  210  is chosen to provide a first processing site, such as a first restriction enzyme recognition site, such as a type II restriction endonuclease (e.g., Bsm1), to generate the desired nucleotide overhang at the first end of the double-stranded precursor molecule for ligation in a head to tail configuration, and for precise cleavage of the 5′ flanking region  210  from the capture probe  200  region. 
     The 3′ flanking region  220  is typically from about 4 to about 30 nucleotides in length, such as from about 5 to about 25 nucleotides in length, or from about 10 to 20 nucleotides in length. The nucleotide sequence of the 3′ flanking region  220  is chosen to provide a second processing site, such as a second restriction enzyme recognition site (e.g., Bsm1), to generate the desired nucleotide overhang at the second end of the double-stranded molecule for ligation. In some embodiments, the 3′ flanking region  220  further comprises an additional processing site (e.g., a third restriction enzyme recognition site, such as Psi1 or HindIII) for precise cleavage of the 3′ flanking region  220  from the capture probe  200  region. 
     As illustrated in  FIG. 4 , step B, the population of double-stranded capture probe precursors  230  are processed into ligation substrates that form head-to-tail concatemers upon ligation with one another. Accordingly, the first processing site in the 5′ flanking region and the second processing site in the 3′ region are chosen such that upon digestion of the first and second processing sites in the double-stranded precursor  230 , nucleotide overhangs are left on each end of the double-stranded precursor that can only ligate with one another in a head to tail configuration (e.g., a “CC” overhang on the first end of the molecule and a “GG” overhang on the second end of the molecule, as illustrated in  FIG. 4 , step C). 
     It will be understood by one of skill in the art that Bsm1 is a non-limiting example of a type II restriction endonuclease that recognizes an asymmetric sequence and cleaves outside of that asymmetric sequence to yield the desired nucleotide overhangs at the first end and the second end of the double-stranded precursor molecule for ligation in a head to tail configuration. For example, dozens of type II restriction endonuclease enzymes are commercially available and known to those of skill in the art (see, e.g., New England Biolabs catalogue and REBASE web site) from which one of skill in the art could design a first processing site in the 5′ flanking region and a second processing site in the 3′ flanking region to provide ligation substrates that could only ligate in a head to tail configuration. 
     The double-stranded capture probe precursor  230  for use in various embodiments of the methods of the invention may be generated using a variety of methods. In one embodiment, the double-stranded capture probe precursor  230  is generated by synthesizing pairs of single-stranded complementary sense and antisense oligonucleotides comprising the full length sequence of the capture probe precursor  230  and annealing the strands together to form the double-stranded capture probe precursor. In another embodiment, a ligation ready, double-stranded capture probe precursor  230  having from one to four nucleotide overhangs on each end, is generated by annealing a pair of synthesized complementary strands together to produce the desired nucleotide overhang that will result in head-to-tail concatemers upon ligation. 
     In another embodiment, as shown in  FIG. 4 , step A, and demonstrated in Example 1, a population of double-stranded precursor molecules  230  is generated by first synthesizing a population of single-stranded oligonucleotide precursors  100  comprising a 5′ flanking region  210 , a target-specific binding region  202 , and a portion of the capture reagent binding region  204  (e.g., at least 10 to 20 nucleotides) and annealing the synthesized population of oligos  100  with a common reverse primer oligonucleotide  150  to form the double-stranded capture probe precursor molecules  230 . As illustrated in  FIG. 4 , the common reverse primer oligo  150  is designed to hybridize to the region  204  for binding to a capture reagent on the synthesized oligos  100 , and includes the complement of the remaining portion of the region  204 , as well as the complement of the 3′ flanking region  220 . An advantage to the second strand fill in reaction with the reverse primer oligo  150  is the ability to change the 3′ flanking region through the use of a reverse primer oligo  150  with different sequences in order to incorporate different restriction enzyme sites or other desired sequences in the 3′ flanking region  220  of the double-stranded capture probe precursor molecule  230 . For example, other sequences that could be included in the 3′ flanking region  220  include primer binding sites, protein binding sites (e.g., for binding a prokaryotic polymerase such as T7 RNA polymerase), modified nucleotides for purification (e.g., biotinylated residues), or methylated 5-methylated 5-methyl-cytosine residues for resistance to bisulphate conversion. 
     Referring again to  FIG. 3 , at step  620 , the population of double-stranded capture probe precursors  230  are processed into ligation substrates that form head-to-tail concatemers upon ligation with one another, as illustrated in  FIG. 4 , step B. One of skill in the art can use art-recognized methods to determine the sequence of a 5′ flanking region  210  and a 3′ flanking region  220  that will provide suitable processing sites, such as restriction endonuclease recognition sites, for generating a first overhang of from 1 to 12 nucleotides on the first end and a second overhang of from 1 to 12 nucleotides on the second end of the double-stranded capture probe precursor  230 . In a non-limiting example, as described in Example 1, the double-stranded capture probe precursors  230  are designed to include a 5′ flanking region  210  comprising a first restriction enzyme site for Bsm1, in order to create a two nucleotide “GG” overhang at the first end of the precursor  230  molecule, and a 3′ flanking region  220  comprising a second restriction enzyme site for Bsm1, in order to create a two nucleotide “CC” overhang at the second end of the precursor  230  after digestion with Bsm1 to facilitate ligation into head-to-tail concatemers, as illustrated in  FIG. 4 , step B. 
     At step  630 , the processed capture probe precursors are ligated to generate head-to-tail concatemers  240 , as illustrated in  FIG. 4 , step C. As illustrated in  FIG. 4 , step C, it is noted that the ligation reaction naturally drives towards the formation of circularized templates due to the fact that in very dilute solutions of free ends, the probability of self-ligation (circularization) becomes higher than the probability of finding a separate free end. 
     At step  640 , the head-to-tail concatemers  240  are amplified using any suitable amplification method, such as PCR amplification, in vitro transcription, Klenow, or isothermal amplification. 
     In one embodiment, the amplification of the head-to-tail concatemers  240  is carried out using isothermal amplification with either  Bacillus subtilis  phage phi29 polymerase (hereafter referred to as “phi29” polymerase) or  Bacillus stearothermophilus  (Bst) DNA polymerase large fragment, 5′→3′ exo −  (hereafter referred to as “Bst DNA polymerase”). Isothermal amplification is based on random priming of denatured DNA, followed by strand-displacement synthesis at constant temperature, wherein multiple primers are extended over tens of kilobases, as described in Lage et al., Genome Res 13:294-307 (2003), incorporated herein by reference. The single-stranded DNA generated by strand displacement is targeted by new random priming events, and these new strands are elongated in the opposite direction, resulting in a hyperbranched network of amplified head-to-tail concatemers, as shown in  FIG. 4 , step D. 
     In one embodiment, as illustrated in  FIG. 4 , step D, a random primer  250  is used for amplification using the strand displacement polymerase technology found in the TEMPLIPHI isothermal amplification kit (phi29) (GE Life Sciences, Piscataway N.J.). In one embodiment, the random primer  250  comprises a random 7-mer amplification primer with an additional two nitroindole residues at the 5′ end and a phosphorothioate linkage at the 3′ end: 5′[nitroindole]2-[N]6-(phosphothioate)-N (SEQ ID NO:77), as described by Lage et al., Genome Res 13:294-307 (2003). 
     At step  650 , the amplified head-to-tail concatemers are processed to release monomer double-stranded capture probe precursors. In one embodiment, as shown in  FIG. 4 , step E, the concatemers are processed by restriction enzyme cleavage using a type II restriction enzyme that recognizes a site present in the 5′ and 3′ flanking regions, such as Bsm1. 
     At step  660 , the amplified monomer double-stranded precursor molecules are processed to remove the 5′ and/or 3′ flanking regions. In one embodiment, as shown in  FIG. 4 , step E and step F, the 5′ flanking region is precisely removed by digestion with Bsm1 and the 3′ flanking region is precisely removed by digestion with either Psi1 or HindIII. 
     At step  670 , the monomer double-stranded precursor molecules are further processed to selectively remove the complementary strand of the capture probe to produce a population of single-stranded target specific capture probes  200 . 
     In one embodiment, as shown in  FIG. 4 , at step E, the Bsm1 digested monomers are treated with alkaline phosphatase to remove the 5′ terminal phosphates. At step F, the precise 3′ ends of capture probes are then liberated by digestion with either PsiI or HindIII, which each leaves 5′ terminal phosphates on the complementary strands. At step G, single-strand capture probe  200  libraries containing only the target specific region  202  and the capture reagent binding region  204  are generated by digesting the double-stranded monomer capture probe precursors with an enzyme, such as Lambda exonuclease, that specifically degrades dsDNA by attacking at 5′ phosphate sites and selectively digests away the non-capture complementary strand, thereby converting the dsDNA into ssDNA suitable for use as capture probes. 
     Alternatively, the non-capture complementary strand may be removed by first adding exonuclease resistant adaptors to the capture probe strand and degrading away the non-capture complementary strand with any suitable double-strand DNA specific exonuclease, such as Exonuclease III. In another example, the capture strand may be selectively amplified by adding an amplification primer binding site in the 5′ flanking region  210  of the capture probe precursor  230 , and selectively amplifying the plurality of amplified capture probe monomers  270  with an amplification primer that binds to the amplification primer binding site. 
       FIG. 5  illustrates further details of the method illustrated in  FIG. 4 , with regard to a library of single-stranded nucleic acid probes having distinct predetermined sequences A, B, C, and D, such as target-specific capture probes. It will be understood that the method of generating the library comprising probes A, B, C and D is representative for generating a library comprising at least 1,000, such as at least 5,000, such as at least 10,000, such as at least 50,000, such as at least 100,000, such as at least 1,000,000 or more single-stranded nucleic acid probes having predetermined nucleic acid sequences, such as target-specific capture probes. As shown in  FIG. 5 , step A, a library of single-stranded precursor molecules  100  is synthesized on a substrate  102 , the synthesized population comprising a 5′ flanking region  210 , a target specific binding region  202  and a portion of the capture reagent binding region  204 , wherein each of the target specific binding regions comprises a nucleic acid sequence selected to bind to target sequence A, B, C, or D. 
     The synthesized library of single-stranded precursor molecules  100  is then cleaved off the substrate  102 , annealed to a common reverse primer  150  and extended with Klenow, to generate a library of double-stranded capture probe precursor molecules  230  (best illustrated in  FIG. 4 ). Accordingly, the library of double-stranded nucleic acid precursor molecules  230  comprises a 5′ flanking region  210  that is essentially identical to every other 5′ flanking region in the library, a 3′ flanking region  220  that is essentially identical to every other 3′ flanking region in the library, and a probe region  200  comprising a nucleic acid sequence  202  that is different from a least a portion of the nucleic acid sequence  202  present in every other probe region  200 . 
     Referring again to  FIG. 5 , at step C, the 5′ and 3′ regions of the double-stranded capture probe precursor molecules  230  are then processed to generate ligation substrates and ligated to form head-to-tail concatemers  240  as described with reference to  FIG. 4 . As illustrated in  FIG. 5 , step C, the head-to-tail concatemers  240  each comprise a plurality of ligated monomer capture probe regions (A, B, C, D) that are randomly ligated together. At step D, the circularized concatemers  240  are amplified via isothermal amplification with random primers 250, resulting in a plurality of amplified concatemers  260  (best shown in  FIG. 4 ), which are then processed (e.g., with Bsm1) at Step E to generate a library of amplified capture probe monomers  270 , which are further processed to remove the non-capture complementary strands, as described with reference to  FIG. 4 , into a library of single-stranded capture probes  200  comprising a plurality of different target specific binding regions  202  (e.g., that specifically bind to targets A, B, C, and D). 
     In some embodiments of the methods described herein, a library of capture probe precursors in the form of head-to-tail concatemers, with reference to  FIG. 4 , step C (e.g., the ligation mixture), or amplified head-to-tail concatemers, with reference to  FIG. 4 , step D (e.g., the amplified reaction) may be stored at −20° C. for a period of time from several hours up to 6 months or longer, for use as a template in a subsequent amplification reaction, in order to generate additional yields of the capture probe library  200 , thus avoiding the need for repeated oligonucleotide synthesis of a particular library of capture probes. 
     The population of single-stranded capture probes  200  can be used in solution based capture methods as described herein. As demonstrated in Example 2, and shown in  FIG. 6 , it has been determined that the single-stranded capture probes generated from amplified head-to-tail concatemers, in accordance with the methods of the invention, work at least as well for solution based capture methods as a population of corresponding capture probes that were generated by direct oligonucleotide synthesis. Therefore, it is demonstrated that the methods are useful for generating a library of uniformly amplified single-stranded capture probes from a starting population of double-stranded capture probe precursor molecules. 
     The level of representation of expected nucleic acid sequences in a library generated according to the methods of the invention typically has a variation of less than about 30% (such as a variation of less than about 20%). The level of representation of expected nucleic acid sequence in the final single stranded capture probe library  200  may be assessed using various methods. For example, as described in Example 2, a capture probe library  200  may be used for solution-based capture of a set of targets (e.g., the 13 exons of the AKT gene), and the standard deviation of the exon to exon capture efficiency, expressed as a percentage of the fold-enrichment can be determined, as shown in  FIG. 6 , thereby providing an indirect measure of the representation of the expected nucleic acid sequences in the capture probe library  200 . As another example, quantitative PCR assays may be carried out for representative target sequences at an early step in the method shown in  FIG. 4 , such as after initial synthesis of the single-stranded precursor nucleic acid molecules  100 , or after formation of the double-stranded precursor molecules  230 , and compared to quantitative PCR results obtained from the final population of single-stranded capture probes  200  to verify uniform representation of the target sequence. As another example, a test sample that is representative of the final population of single-stranded capture probes  200  can be labeled and hybridized to a substrate comprising a population of nucleic acid molecules comprising the set of predetermined sequences expected to be present in the final population of single-stranded capture probes  200 , and the representation of the expected nucleic acids in the test sample is evaluated by analyzing the resulting hybridization pattern. 
     Oligonucleotide Synthesis 
     DNA synthesis of the various oligonucleotides of the invention (e.g., single-stranded nucleic acid molecules having predetermined sequences, capture probe precursors and universal adaptor oligonucleotides) can be carried out by any art-recognized chemistry, including phosphodiester, phosphotriester, phosphate triester, or N-phosphonate and phosphoramidite chemistries (see, e.g., Froehler et al., Nucleic Acid Res. 14:5399-5407, 1986; McBride et al., Tetrahedron Lett. 24:246-248, 1983). Methods of oligonucleotide synthesis are well known in the art and generally involve coupling an activated phosphorous derivative on the 3′ hydroxyl group of a nucleotide with the 5′ hydroxyl group of the nucleic acid molecule (see, e.g., Gait, Oligonucleotide Synthesis: A Practical Approach, IRL Press, 1984). 
     A population of nucleic acid molecules can be synthesized on a substrate by any art-recognized means including, for example, photolithography (see, Lipshutz et al., Nat. Genet. 21(1 Suppl):20-24, 1999) and piezoelectric printing (see, Blanchard et al., Biosensors and Bioelectronics 11:687-690, 1996). In some embodiments, nucleic acid molecules are synthesized in a defined pattern on a solid substrate to form a high-density microarray. Techniques are known for producing arrays containing thousands of oligonucleotides comprising defined sequences at defined locations on a substrate (see, e.g., Pease et al., Proc. Nat&#39;l. Acad. Sci. 91:5022-5026, 1994; Lockhart et al., Nature Biotechnol. 14:1675-80, 1996; and Lipshutz et al., Nat. Genet. 21 (1 Suppl):20-4, 1999). 
     In some embodiments, populations of nucleic acid molecules are synthesized on a substrate, to form a high density microarray, by means of an ink jet printing device for oligonucleotide synthesis, such as described by Blanchard in U.S. Pat. No. 6,028,189; Blanchard et al., Biosensors and Bioelectrics 11:687-690 (1996); Blanchard, Synthetic DNA Arrays in Genetic Engineering, Vol. 20, J. K. Setlow, Ed. Plenum Press, New York at pages 111-123; and U.S. Pat. No. 6,028,189 issued to Blanchard. The nucleic acid sequences in such microarrays are typically synthesized in arrays, for example, on a glass slide, by serially depositing individual nucleotide bases in “microdroplets” of a high surface tension solvent such as propylene carbonate. The microdroplets have small volumes (e.g., 100 picoliters (pL) or less, or 50 pL or less) and are separated from each other on the microarray (e.g., by hydrophobic domains) to form surface tension wells which define the areas containing the array elements (i.e., the different populations of nucleic acid molecules). Microarrays manufactured by this ink-jet method are typically of high density, typically having a density of at least about 2,000 different nucleic acid molecules per 1 cm 2 . The nucleic acid molecules may be covalently attached directly to the substrate, or to a linker attached to the substrate at either the 3′ or 5′ end of the polynucleotide. Exemplary chain lengths of the synthesized nucleic acid molecules suitable for use in the present methods are in the range of about 20 to about 100 nucleotides in length, such as 50 to 100, 60 to 100, 70 to 100, 80 to 100, or 90 to 100 nucleotides in length. In some embodiments, the nucleic acid molecules are in the range of 80 to 100 nucleotides in length. 
     Exemplary ink jet printing devices suitable for oligonucleotide synthesis in the practice of the present invention contain microfabricated ink-jet pumps, or nozzles, which are used to deliver specified volumes of synthesis reagents to an array of surface tension wells (see, Kyser et al., J. Appl. Photographic Eng. 7:73-79, 1981). 
     In some embodiments, a population of nucleic acid molecules is synthesized to form a high-density microarray. A DNA microarray, or chip, is an array of nucleic acid molecules, such as synthetic oligonucleotides, disposed in a defined pattern onto defined areas of a solid support (see, Schena, BioEssays 18:427, 1996). The arrays are preferably reproducible, allowing multiple copies of a given array to be produced and easily compared with each other. Microarrays are typically made from materials that are stable under nucleic acid molecule hybridization conditions. In some embodiments, the nucleic acid molecules on the array are single-stranded DNA sequences. Exemplary microarrays and methods for their manufacture and use are set forth in T. R. Hughes et al., Nature Biotechnology 19:342-347, April 2001, which publication is incorporated herein by reference. 
     In some embodiments, the methods of the invention utilizes oligonucleotides that are synthesized on a multiplex parallel DNA synthesis system based on an integrated microfluidic microarray platform for parallel production of oligonucleotides, wherein the DNA synthesis system utilizes photogenerated acid chemistry, parallel microfluidics and a programmable digital light controlled synthesizer, as described in U.S. Patent Pub. No. 2007/0059692, Gao et al., Biopolymers 73:579-596 (2004), and Zhou et al., Nucleic Acids Research 32(18):5409-5417 (2004), each of which is incorporated herein by reference. 
     In some embodiments, the methods of the invention utilize synthesized oligonucleotides that are cleaved off a substrate, such as a microarray. The synthesized nucleic acid molecules can be harvested from the substrate by any useful means. In some embodiments, the portion of the nucleic acid molecule that is directly attached to the substrate, or attached to a linker that is attached to the substrate, is attached to the substrate or linker by an ester bond which is susceptible to hydrolysis by exposure to a hydrolyzing agent, such as hydroxide ions, for example, an aqueous solution of sodium hydroxide or ammonium hydroxide. The entire substrate can be treated with a hydrolyzing agent, or alternatively, a hydrolyzing agent can be applied to a portion of the substrate. For example, a silane linker can be cleaved by exposure of the silica surface to ammonium hydroxide, yielding various silicate salts and releasing the nucleic acid molecules with the silane linker into solution. In some embodiments, ammonium hydroxide can be applied to the portion of a substrate that is covalently attached to the nucleic acid molecules, thereby releasing the nucleic acid molecules into the solution (see, Scott and McLean, Innovations and Perspectives in Solid Phase Synthesis, 3 rd  International Symposium, 1994, Mayflower Worldwide, pp. 115-124). 
     In another aspect, the present invention provides a method for enriching a library for target nucleic acid regions of interest. The methods according to this aspect of the invention comprise: (a) amplifying a plurality of head-to-tail concatemers formed from ligating a population of double-stranded nucleic acid precursor molecules, wherein each double-stranded precursor molecule in the starting population comprises a target capture probe region comprising (i) a target-specific binding region comprising a nucleic acid sequence that is at least 95% identical to at least a portion of the sense or antisense strand of a target nucleic acid sequence of interest and (ii) a region for binding to a capture reagent; wherein the target capture region is flanked on the 5′ end by a 5′ flanking region comprising a first processing site and is flanked on the 3′ end by a 3′ flanking region comprising a second processing site; (b) processing the amplified head-to-tail concatemers to release double-stranded monomer precursor molecules; (c) selectively removing the complement strand of the double-stranded monomer precursor molecules to generate a population of single-stranded capture probes, each capture probe comprising (i) a target-specific binding region comprising a nucleic acid sequence that is at least 95% identical to at least a portion of the sense or antisense strand of a target nucleic acid sequence of interest and (ii) a region for binding to a capture reagent; (d) contacting the population of single-stranded capture probes with a library comprising at least one target nucleic acid sequence of interest under conditions that allow binding between the capture probes and the at least one nucleic acid target region of interest, to form a mixture comprising a plurality of complexes between target regions of interest and capture probes; (e) contacting the mixture of step (d) with a capture reagent and separating the capture reagent bound complex from the mixture; and (f) eluting the target regions of interest from the capture reagent bound complex. 
     The steps (a) to (c) may be carried out as previously herein described. The steps (d) to (f) of enriching a library for target sequences with the population of single-stranded capture probes may be carried out as illustrated in  FIG. 2 . As shown in  FIG. 2A , solution-based capture is carried out by first annealing the library of single-stranded capture probes  200 , each capture probe comprising a target specific region  202  that hybridizes to a target sequence contained in a library insert, with a library of nucleic acid molecules  50  comprising nucleic acid target insert sequences of interest  10  flanked by a first primer binding region  22  on one end and a second primer binding region  32  on the other end. As further shown in  FIG. 2 , step A, in one embodiment, the library of nucleic acid molecules  50  is annealed with a combination of a library of single-stranded capture probes  200  each comprising a region  204  that hybridizes to a universal adaptor oligo  300  and an equimolar amount of universal adaptor oligos  300  comprising a moiety  310  for binding to a capture reagent  400 . 
     The annealing step is typically carried out by mixing a molar excess of capture probes (or capture probes plus universal adaptor oligos) with the library in a high salt solution comprising from 100 mM to 2 M NaCl (osmolarity=200 to 4000 molar). An exemplary high salt solution for annealing is 10 mM Tris pH 7.6, 0.1 mM EDTA, 1 M NaCl (osmolarity=2000 molar). The nucleic acid molecules in the mixture are then denatured (i.e., by heating to 94 degrees) and allowed to cool to room temperature. In one embodiment, the annealing step is carried out in a high salt solution comprising from 100 mM to 2 M NaCl with the addition of 0.1% triton X100 (or Tween or NP40) nonionic detergent. 
     An amount of capture reagent  400  is added to the annealed mixture sufficient to generate a plurality of complexes each containing a nucleic acid molecule, a capture probe (or a capture probe and a universal adaptor oligo), and a capture reagent. This step is carried out in a high salt solution comprising from 100 mM to 2 M NaCl (osmolarity=200 to 4000 molar). An exemplary high salt solution for anneal is 10 mM Tris pH 7.6, 0.1 mM EDTA, 1 M NaCl (osmolarity=2000 molar). The mixture is incubated at room temperature with mixing for about 15 minutes. 
     The complexes formed are then isolated or separated from solution with a sorting device  500  (e.g., a magnet) that pulls or sorts the capture reagent  400  out of solution. 
     The sorted complexes bound to the capture reagent  400  are washed with a low salt wash buffer (less than 10 mM NaCl, and more preferably no NaCl) to remove non-target nucleic acids. An exemplary low salt wash buffer is 10 mM Tris pH 7.6, 0.1 mM EDTA (osmolarity=10 millimolar). In some embodiments, the low salt wash optionally contains from 15% to 30% formamide, such as 25% formamide (osmolarity=6.3 molar). For each wash step, the capture reagent  400  bound to the complexes (e.g., magnetic beads) are resuspended in the low salt wash buffer and rocked for 5 minutes, then sorted again with the sorting device (magnet). The wash step may be repeated 2 to 4 times. 
     The nucleic acid molecules containing the target sequences are then eluted from the complexes bound to the capture reagent as follows. The washed complexes bound to the capture reagent  400  are resuspended in water, or in a low salt buffer (i.e., osmolarity less than 100 millimolar), heated to 94° C. for 30 seconds, the capture reagent (e.g., magnetic beads) is pulled out using a sorting device (e.g., magnet), and the supernatant (eluate) containing the target nucleic acid molecules is collected. 
     The eluate may optionally be amplified in a PCR reaction with a first PCR primer that binds to the first primer binding site  22  in the first linker and a second PCR primer that binds to the second primer binding site  32  in the second linker, producing an enriched library which can be optionally sequenced. 
     In another aspect, the present invention provides kits for generating a population of single-stranded nucleic acid molecules from a population of precursor double-stranded molecules. The kits according to this aspect of the invention are useful for carrying out various embodiments of the methods of the invention described herein. The kits in accordance with this aspect of the invention comprise (a) a plurality of random 7-mer oligonucleotide primers, (b) at least one of phi29 polymerase or Bst DNA polymerase large fragment 5′-3′ exo-; and (c) a lambda exonuclease enzyme. In some embodiments of the kit, the plurality of random 7-mer oligonucleotide primers each comprise an additional two nitroindole residues at the 5′ end and a phosphorothioate linkage at the 3′ end (SEQ ID NO:77). In some embodiments, the kit may further comprise at least one of the following: an alkaline phosphatase enzyme, at least one type II restriction enzyme, a DNA ligase, and a DNA polymerase enzyme (Klenow). 
     In an embodiment of the kit comprising phi29 polymerase, the kit may optionally further comprise one or more of the following reagents: (i) a phi29 concentrated stock reaction buffer comprising at least one of the following: Tris-HCL (e.g., at 50 mM for 10× buffer), (NH 4 ) 2 SO 4  (e.g., at 10 mM for 10× buffer), MgCl 2  (e.g., 10 mM for 10× buffer) and dithiothreitol (e.g., 4 mM for 10× buffer); (ii) a concentrated stock of dNTPs (e.g. from 100 μM to 10 mM dNTPs); and (iii) a reducing agent, such as dithiothreitol. In further embodiments, the kit may optionally comprise at least one or more of the following; a common reverse primer oligo  150  designed to hybridize to the region  204  for binding to the synthesized oligos  100 , Klenow enzyme, at least one Type II Restriction Enzyme, ligase, and alkaline phosphatase. 
     The following examples merely illustrate the best mode now contemplated for practicing the invention, but should not be construed to limit the invention. 
     EXAMPLES 
     All of the compositions and methods disclosed and claimed herein can be made and executed without undue experimentation in light of the present disclosure. In some cases, the compositions and methods of this invention have been described in terms of embodiments, however these embodiments are in no way intended to limit the scope of the claims, and it will be apparent to those of skill in the art that variations may be applied to the compositions and/or methods and in the steps or in the sequence of steps of the methods described herein without departing from the concept, spirit and scope of the invention. More specifically, it will be apparent that certain components which are both chemically and physiologically related may be substituted for the components described herein while the same or similar results would be achieved. All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined by the appended claims. 
     Example 1 
     This Example demonstrates a method for uniformly amplifying a library of target capture probes specific for the AKT gene designed for solution based capture of the 13 exons of the AKT gene. 
     Rationale: 
     Several recent studies describe the complete resequencing of human genomes (Wang et al., Nature 456:60 (2008); Bentley et al., Nature 456:53 (2008); Ley et al., Nature 456:66 (2008)). One in particular describes the full genome sequence of a tumor and normal adjacent tissue (Ley et al. (2008)). Remarkably, the authors distill their analysis of the complete human genome to ten mutated genes, highlighting the point that a small percentage of human genome sequence variations, including the protein coding regions and some surrounding flanking sequences, is interpretable. At the opposite end of the spectrum, candidate gene resequencing strives to test phenotype to genotype hypotheses by seeking sequence variation in specific genes that are thought to influence traits. The caveat is that the selection of candidate genes can be somewhat arbitrary. The ideal solution is one in which the interpretable regions, referred to as the “exome” of the genome, can be selectively resequenced. As used herein, the term “exome” refers to the collection of genomic segments that include protein coding regions, exons, promoters, known ncRNAs (non-coding RNAs) and UTRs, altogether comprising about 2% of the human genome. Interestingly, if the exome could be captured from a sample, then the sequencing data from a single flow cell from a highly parallel sequencing technology (e.g., a single Illumina GAII flow cell) would be adequate to address all of the diploid variation present in the exomic fraction of that sample. 
     Solution-based capture of the human exome would require ˜2 million oligonucleotides. Even with state-of-the-art, high-throughput oligo synthesis stations, the cost of each capture oligo is $7 and therefore the cost of synthesizing an exome solution based capture library would be approximately $14 million. An alternative—synthesized oligonucleotide libraries cleaved from microarrays, also initially appears to be an untenable solution due to the high cost involved to obtain sufficient yields of material. Each microarray typically produces about 50,000 individual oligonucleotide sequences that are high-quality, cleavable oligos in picomole quantities (e.g., commercially available from Agilent, Santa Clara, Calif.). Thus, the cost of synthesizing a library of exome capture oligonucleotide probes from microarrays (requiring ˜40 arrays at an estimated cost of $400,000) is substantially reduced relative to conventional oligonucleotide synthesis, however, the yield of material produced by microarray synthesis is sufficient for only four solution based capture experiments. Moreover, the use of high density probe coverage (i.e., more than 4 probes per exon, or at least one capture probe per 35 nt), as shown in  FIG. 1B , is preferable for solution based capture in comparison to low density probe coverage (i.e., less than 3 probes per exon, or less than one capture probe per 35 nt), as shown in  FIG. 1A . The use of high density probe coverage is preferred in order to ensure that desired targets are enriched, thereby reducing the depth of re-sequencing required of the enriched material. However, such high density probe coverage calls for a greater number of capture oligonucleotides, which significantly inflates the overall expense of technologies that utilize solution based capture methods. Therefore, a need exists to provide a cost-effective method for generating high quality custom oligonucleotide libraries with sufficient yield for applications such as solution based capture. 
     This Example demonstrates a method for uniformly amplifying a library of synthesized capture oligonucleotides for use in solution based capture methods. 
     Design of Capture Probe Oligonucleotide Precursors for Amplification and Processing into a Library of Capture Probes: 
     As shown in  FIG. 1C , capture probes  200  may be used to capture nucleic acid molecules comprising target sequences  10  from a mixture of target and non-target nucleic acid molecules. As shown in  FIG. 1C , capture probes  200  comprise a target-specific binding region  202  and a region  204  for binding to a capture reagent  300 . In the embodiment shown in  FIG. 1C , the capture reagent  300  is a universal adaptor oligonucleotide comprising a moiety  310  that binds to a capture reagent, thereby resulting in a tri-molecular solution based capture complex. 
     Design of Capture Probe Precursor Oligonucleotides: 
       FIG. 4  at Step A illustrates the general structure of a double-stranded capture probe precursor  230  prior to processing into a single-stranded capture probe  200 . The double-stranded capture probe precursor was designed to ensure that the ligation of a plurality of double-stranded capture oligonucleotide probe precursors  230  would result in head-to-tail concatemers  240 , as illustrated at Step C, which were then used as templates for amplification, as illustrated at Step D, followed by cleavage into monomers and alkaline phosphatase, as illustrated at Step E, followed by selective degradation of the complementary strand of the capture probe precursor, as shown at Step G, thereby generating a single-stranded capture probe  200  comprising a target-specific binding region  202  and a region  204  for binding to a capture reagent  300 , without the 5′ flanking region  210  and the 3′ flanking region  220 . 
     As shown in  FIG. 4 , Step A, the general structure of the double-stranded capture probe precursor  230  includes a 5′ flanking region  210  comprising a first restriction enzyme site for creating a first nucleotide overhang for ligation (e.g., Bsm1); a capture probe region  200  comprising a target specific hybridizing region  202  and a universal capture oligo hybridizing region  204 , and a 3′ flanking region  220  comprising a second restriction enzyme site (e.g., Bsm1) for creating a second nucleotide overhang for ligation, and further comprising a third restriction enzyme site (e.g., Psi or HindIII), for precisely cleaving off the 3′ flanking region. 
     Design of the Target-Specific Region  202  of the Capture Probe  200 : 
     In this Example, a 64 oligonucleotide library was synthesized for high density solution based capture of the 13 exon AKT1 gene (NM — 005163). As illustrated in  FIG. 1B , a library of oligonucleotide capture probes were designed such that each target AKT1 exon had at least 4 or more probes (high density), and the capture probes alternated in strand orientation and were perfectly head to tail with no spaces in between, each having the sequence identical to the corresponding exon sequences 1-13 from the AKT1 gene. The target specific binding regions  202  of the capture probes in the AKT1 capture probe library had a length of 35 nt, as shown below in TABLE 1. 
     Design of the Region  204  for Binding to a Capture Reagent  300 : 
     The AKT1 capture probes  200  in the library were designed such that each final processed single-stranded capture probe had a 34 nucleotide common region  204  for binding to the universal oligo adaptor capture reagent  300 . 
     As shown in  FIG. 4 , Step A, in order to further reduce costs of oligonucleotide synthesis, in this Example, the initial population of synthesized oligos  100  included the 5′ flanking region  210 , the target specific binding regions  202 , and only a portion (15 nt of the 34 nt region) of the common region  204  for binding to a capture reagent  300 . As shown in  FIG. 4 , Step A, the 15 nt of the region  204  (5′ ACGCGTGGCGGATGT 3′ (SEQ ID NO:1)) binds to a region of the reverse primer  150  that was used to anneal and fill-in the library synthesized oligos  100 , thereby resulting in the double-stranded capture probe precursors  230 . 
     Design of the 5′ Flanking Region  210  of the Capture Probe Precursor  230 : 
     The double-stranded AKT1 capture probe precursors  230  were designed to include a 5′ flanking region  210  comprising a first restriction enzyme site for Bsm1, in order to create a two nucleotide “GG” overhang at the first end of the precursor molecules  230  after digestion with Bsm1 to facilitate ligation into head-to-tail concatemers. 
     The 5′ flanking region  210  of the capture probe precursors in this Example had the following sequence: 5′ CGCGAATGCC 3′ (SEQ ID NO:2) to provide a first Bsm1 site. 
     Design of the 3′ Flanking Region  220  of the Capture Probe Precursor  230 : 
     The double-stranded AKT1 capture probe precursors  230  were designed to include a 3′ flanking region  220  comprising a second restriction enzyme site for Bsm1, in order to create a two nucleotide “CC” overhang at the second end of the precursor  230  molecule after digestion with Bsm1 to facilitate ligation into head-to-tail concatemers. 
     The 3′ flanking region was designed to also include a third restriction enzyme recognition sequence to precisely cleave off the 3′ flanking region after amplification, and also leave 5′ terminal phosphates on the complementary strands (e.g., Psi1 or HindIII). 
     Using the general design principles described above, several series of oligonucleotides were synthesized as follows: 
     “A” Series: a control set of 64 AKT capture probes that were directly synthesized (not amplified) having a total length of 69 nucleotides. 
     “B” Series: a set of 64 AKT capture probe precursor oligonucleotides for amplification, but which did not impose the head to tail ligation characteristics (later abandoned, as discussed below in the results section). 
     “C” Series: a set of 64 AKT capture probe precursor oligonucleotides for amplification, having a total length of 79 nucleotides (34 nt  204  region that binds to the reverse primer  150 , with the same 5′ flanking region  210  and target specific region  202  as D series). Note: this series was more expensive to synthesize because they required 0.2 micromolar synthesis, due to the longer size. 
     “D” Series: a set of 64 AKT capture probe precursor oligonucleotides for amplification, having a total length of 60 nucleotides, including a 15 nt  204  region that binds to the reverse primer  150 , with a 10 nucleotide 5′ flanking region  210  and a 35 nucleotide target-specific region  202 . Note: this series was much less expensive because it was synthesized on a 50 nmole scale, due to shorter size, which was then extended with the reverse primer and Klenow fill-in reaction. 
     As described above, the C and D series oligos were designed such that after the fill-in reaction with the common reverse primer  150 , a pair of asymmetric Bsm1 sites were created on the double-stranded precursor molecule  230 , such that following digestion with Bsm1, a two nucleotide “CC” overhang is present on the top strand of each double-stranded oligonucleotide and a two nucleotide “GG” overhang is present on the bottom strand of each double-stranded oligonucleotide, thus creating a situation in which only head-to-tail ligation events are allowed. Moreover, ligation recreates the Bsm1 site for downstream processing after amplification. As described in detail below, the Bsm1 digested amplification products were then treated with Antarctic phosphatase to dephosphorylate the 5′ end of the capture strand while leaving an exposed 5′ phosphate on the complement strand to allow for degradation by treatment with lambda exonuclease, to generate the desired single-stranded capture probes. 
     For the “D” Series oligos each capture probe precursor  100  was synthesized as shown below in TABLE 1, with the 5′ regions  210  and the 3′ regions  220  underlined. 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 The D Series probes for AKT (NM_005163) 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Distance 
                   
                   
                 SEQ 
                   
               
               
                   
                 from exon 
                   
                   
                 ID 
               
               
                 Exon 
                 5′ edge 
                 Strand 
                 Probe Sequence 
                 NO: 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1 
                 −35 
                 − 
                   CGCGAATGCC GGTGCCCGAGGCTCCCGCGACGCTCACGCGCTCCT ACG   
                 3 
                   
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 1 
                 0 
                 + 
                   CGCGAATGCC ATGAGCGACGTGGCTATTGTGAAGGAGGGTTGGCT ACG   
                 4 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 1 
                 35 
                 − 
                   CGCGAATGCC CCAGCCCTGGCAGCGGGTACTAACCTCGTTTGTGC ACG   
                 5 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 1 
                 70 
                 + 
                   CGCGAATGCC GCCTGGGGAGGGAGAGATGGGGGTAGTAGCCCCAG ACG   
                 6 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 2 
                 −35 
                 − 
                   CGCGAATGCC CTACAGACGTGCGGGTGGTGAGAGCCACGCACACT ACG   
                 7 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 2 
                 0 
                 + 
                   CGCGAATGCC GGGAGTACATCAAGACCTGGCGGCCACGCTACTTC ACG   
                 8 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 2 
                 35 
                 − 
                   CGCGAATGCC TTGTAGCCAATGAAGGTGCCATCATTCTTGAGGAG ACG   
                 9 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 2 
                 70 
                 + 
                   CGCGAATGCC GGAGCGGCCGCAGGATGTGGACCAACGTGAGGCTC ACG   
                 10 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 2 
                 105 
                 − 
                   CGCGAATGCC GGGATACTTACGCGCCACAGAGAAGTTGTTGAGGG ACG   
                 11 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 2 
                 140 
                 + 
                   CGCGAATGCC CTTGGCCTCTCGGGATTCAGATTTGGGGGGTTGGC ACG   
                 12 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 3 
                 −35 
                 − 
                   CGCGAATGCC CTGCGGGCAGGCAGAGCCTCTGTCTGCGTGCATCCACG 
                 13 
               
               
                   
                   
                   
                 CGTGGCGGATGT 
               
               
                   
               
               
                 3 
                 0 
                 + 
                 CGCGAATGCCAGTGCCAGCTGATGAAGACGGAGCGGCCCCGGCCC ACG   
                 14 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 3 
                 35 
                 − 
                   CGCGAATGCC GTGGTCCACTGCAGGCAGCGGATGATGAAGGTGTT ACG   
                 15 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 3 
                 70 
                 + 
                   CGCGAATGCC TGTCATCGAACGCACCTTCCATGTGGAGACTCCTG ACG   
                 16 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 3 
                 105 
                 − 
                   CGCGAATGCC CCTGGCCTGGCCGCCACAGCCCACGTACCGCTCCT ACG   
                 17 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 4 
                 −35 
                 − 
                   CGCGAATGCC CTGCAGGAGGTCAGGTGAGGCTGCAGGCCTGTACC ACG   
                 18 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 4 
                 0 
                 + 
                   CGCGAATGCC GGAGGAGTGGACAACCGCCATCCAGACTGTGGCTG ACG   
                 19 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 4 
                 35 
                 − 
                   CGCGAATGCC GTCCATCTCCTCCTCCTCCTGCTTCTTGAGGCCGT ACG   
                 20 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 4 
                 70 
                 + 
                   CGCGAATGCC TTCCGGTCGGGCTCACCCAGTGACAACTCAGGGGC ACG   
                 21 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 4 
                 105 
                 − 
                   CGCGAATGCC GCTTGGGCTTGGCCAGGGACACCTCCATCTCTTCA ACG   
                 22 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 4 
                 140 
                 + 
                   CGCGAATGCC ACCGCGTGGTGAGGCCTGTCCCCACTTCTGCCTGT ACG   
                 23 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 5 
                 −35 
                 − 
                   CGCGAATGCC CTATGGGCAGGCACCAGGGTCAGCAAGCGGCGCTG ACG   
                 24 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 5 
                 0 
                 + 
                   CGCGAATGCC ACCATGAACGAGTTTGAGTACCTGAAGCTGCTGGG ACG   
                 25 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 5 
                 35 
                 − 
                   CGCGAATGCC CCTTCACCAGGATCACCTTGCCGAAAGTGCCCTTG ACG   
                 26 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 5 
                 70 
                 + 
                   CGCGAATGCC AGAAGGCCACAGGCCGCTACTACGCCATGAAGATC ACG   
                 27 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 5 
                 105 
                 − 
                   CGCGAATGCC GGCCCCACCTTGGCCACGATGACTTCCTTCTTGAG ACG   
                 28 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 6 
                 −35 
                 − 
                   CGCGAATGCC CTGTAAAGCAGGGCTGGGTGAGCTGCCACCCCGCA ACG   
                 29 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 6 
                 0 
                 + 
                   CGCGAATGCC GACGAGGTGGCCCACACACTCACCGAGAACCGCGT ACG   
                 30 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 6 
                 35 
                 − 
                   CGCGAATGCC TCACTGTGAGGAAGGGGTGCCTGGAGTTCTGCAGG ACG   
                 31 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 6 
                 70 
                 + 
                   CGCGAATGCC GTGGGAGCCCAGATGGGGCTGAAGGGCTGGGGCCA ACG   
                 32 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 7 
                 −35 
                 − 
                   CGCGAATGCC CTGCAAGGAAGGGGAGCTGGAACTGCGGCCCCACA ACG   
                 33 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 7 
                 0 
                 + 
                   CGCGAATGCC GCCCTGAAGTACTCTTTCCAGACCCACGACCGCCT ACG   
                 34 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 7 
                 35 
                 − 
                   CGCGAATGCC CCTCGCCCCCGTTGGCGTACTCCATGACAAAGCAG ACG   
                 35 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 7 
                 70 
                 + 
                   CGCGAATGCC TAGGGGCTGGGGCTGCGGGGGATGGACTTCGCGGC ACG   
                 36 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 8 
                 −35 
                 − 
                   CGCGAATGCC CTGCGGGAGGCGCAACCTGAGGCACAGCCGTGGCT ACG   
                 37 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 8 
                 0 
                 + 
                   CGCGAATGCC CTGTTCTTCCACCTGTCCCGGGAGCGTGTGTTCTC ACG   
                 38 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 8 
                 35 
                 − 
                   CGCGAATGCC CAATCTCAGCGCCATAGAAGCGGGCCCGGTCCTCG ACG   
                 39 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 8 
                 70 
                 + 
                   CGCGAATGCC TGTCAGCCCTGGACTACCTGCACTCGGAGAAGAAC ACG   
                 40 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 8 
                 105 
                 − 
                   CGCGAATGCC GCCCGCCAGCGCACCTTGAGGTCCCGGTACACCAC ACG   
                 41 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 9 
                 −35 
                 − 
                   CGCGAATGCC CTAGGGGAAAGGTGGCCTCAGGTCAGTGCCGCCAG ACG   
                 42 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 9 
                 0 
                 + 
                   CGCGAATGCC CTGGAGAACCTCATGCTGGACAAGGACGGGCACAT ACG   
                 43 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 9 
                 35 
                 − 
                   CGCGAATGCC TCCCCTCCTTGCACAGCCCGAAGTCTGTGATCTTA ACG   
                 44 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 9 
                 70 
                 + 
                   CGCGAATGCC TCAAGGACGGTGCCACCATGAAGACCTTTTGCGGC ACG   
                 45 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 9 
                 105 
                 − 
                   CGCGAATGCC GGGGCGCACACCTCGGGGGCCAGGTACTCAGGTGT ACG   
                 46 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 10 
                 −35 
                 − 
                   CGCGAATGCC CTGCACGGGTGGCAGATGGGCAGGACTCGGCATCA ACG   
                 47 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 10 
                 0 
                 + 
                   CGCGAATGCC GTGCTGGAGGACAATGACTACGGCCGTGCAGTGGA ACG   
                 48 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 10 
                 35 
                 − 
                   CGCGAATGCC TCATCTCGTACATGACCACGCCCAGCCCCCACCAG ACG   
                 49 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 10 
                 70 
                 + 
                   CGCGAATGCC TGTGCGGTCGCCTGCCCTTCTACAACCAGGACCAT ACG   
                 50 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 10 
                 105 
                 − 
                   CGCGAATGCC ATCTCCTCCATGAGGATGAGCTCAAAAAGCTTCTC ACG   
                 51 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 10 
                 140 
                 + 
                   CGCGAATGCC CCGCTTCCCGCGCACGCTTGGTCCCGAGGCCAAGT ACG   
                 52 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 10 
                 175 
                 − 
                   CGCGAATGCC CTTGGGGTCCTTCTTGAGCAGCCCTGAAAGCAAGG ACG   
                 53 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 10 
                 210 
                 + 
                   CGCGAATGCC CAGAGGTGAGGGCCGCCCATCCCAGCTACAGGCTA ACG   
                 54 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 11 
                 −35 
                 − 
                   CGCGAATGCC CTGCAGGCAGGAAACAAGGCCACAGTGTCGGTACC ACG   
                 55 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 11 
                 0 
                 + 
                   CGCGAATGCC GCTTGGCGGGGGCTCCGAGGACGCCAAGGAGATCA ACG   
                 56 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 11 
                 35 
                 − 
                   CGCGAATGCC CTGCCACACGATACCGGCAAAGAAGCGATGCTGCA ACG   
                 57 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 11 
                 70 
                 + 
                   CGCGAATGCC CACGTGTACGAGAAGAAGGTGCGGCTGCTCCCCGC ACG   
                 58 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 12 
                 −35 
                 − 
                   CGCGAATGCC CTGCAGAGGTGGGCAGACGGGACAGTCATGAGCTT ACG   
                 59 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 12 
                 0 
                 + 
                   CGCGAATGCC CTCAGCCCACCCTTCAAGCCCCAGGTCACGTCGGA ACG   
                 60 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 12 
                 35 
                 − 
                   CGCGAATGCC CCGTGAACTCCTCATCAAAATACCTGGTGTCAGTC ACG   
                 61 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 12 
                 70 
                 + 
                   CGCGAATGCC CCCAGATGATCACCATCACACCACCTGACCAAGGT ACG   
                 62 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 13 
                 −35 
                 − 
                   CGCGAATGCC CTGTGGGTGTAGACAGCTCAGACCCCGGTGCCCCA ACG   
                 63 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 13 
                 0 
                 + 
                   CGCGAATGCC ATGACAGCATGGAGTGTGTGGACAGCGAGCGCAGG ACG   
                 64 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 13 
                 35 
                 − 
                   CGCGAATGCC CCGCTGGCCGAGTAGGAGAACTGGGGGAAGTGGGG ACG   
                 65 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
               
                 13 
                 70 
                 + 
                   CGCGAATGCC CACGGCCTGAGGCGGCGGTGGACTGCGCTGGACGA ACG   
                 66 
               
               
                   
                   
                   
                 
                   CGTGGCGGATGT 
                 
               
               
                   
               
            
           
         
       
     
     Oligo Synthesis: For this experiment, the initial population of oligonucleotides  100  were synthesized individually in solution by Operon (Huntsville, Ala.). In the future, the oligonucleotides will be synthesized on an array then cleaved. For example, synthesized and cleaved oligonucleotides are commercially available (e.g., available from LC Sciences, Houston, Tex., Agilent also manufactures “Sure-print” oligo arrays, cleaves the oligos and delivers pmol quantities of single-strand reagent). 
     Annealing and Fill-in to Generate Double-Stranded Capture Probe Precursors: 
     As shown in  FIG. 4 , Step A, the population of synthesized single-stranded oligonucleotide precursors  100  (free from substrate) were annealed with a common reverse primer oligonucleotide  150  and filled in with Klenow to form double-stranded capture probe precursor molecules  230  as shown in  FIG. 4 , Step A. The common reverse primer oligo  150  was designed to hybridize to the region  204  for binding to a capture reagent on the synthesized oligos  100 , and includes the complement to the remaining portion of the region  204 , as well as the complement to the 3′ flanking region  220 . An advantage to the second strand fill in reaction with the reverse primer oligo  150  is the ability to change the 3′ flanking region  220  through the use of a reverse primer oligo  150  with different sequences in order to incorporate different restriction enzyme sites or other desired sequences in the 3′ flanking region  220  of the double-stranded capture probe precursor molecule  230 . 
     Design of the Second Strand Reverse Oligonucleotide  150 : 
     The following reverse primer oligonucleotides  150  were used in this Example: 
                            Reverse primer #1: (Psi 1, Bsm1 3′ end)                 (SEQ ID NO: 67)                         5′ GAGGTCGGCATTCTTATAATTGCTCGAAGGGGTCCACATC           CGCCACGCGT 3′;                   Reverse primer #2: (HindIII, Bsm1 3′ end)                 (SEQ ID NO: 68)                         5′GAGGTCGGCATTCAAGCTTAATTGCTCGAAGGGGTCCACA           TCCGCCACGCGT 3′            
Preparation of Oligo Pools and Annealing:
 
     As shown in  FIG. 4A , each oligonucleotide  100  in the pool of synthesized oligonucleotides (e.g., pool D, SEQ ID NO:3-66) was annealed to a common reverse primer  150  (SEQ ID NO:67 or SEQ ID NO:68) and filled-in with Klenow to generate a double-stranded oligonucleotide precursor  230  as follows: 
     Pooling of Oligonucleotides: 
     Each A, B, C, and D series oligos were resuspended to 100 μM, then each of the oligos in the A, B, C, and D series were pooled separately, to create an A series pool, a B series pool, a C series pool, and a D series pool at 100 μM, each pool containing a mixture of 64 different oligonucleotides. The DNA concentration of the oligo pool (100 μm of 70 to 80mer=2 μg/μl) was confirmed by agarose gel electrophoresis by diluting the pool 50-fold to 40 ng/μl, and loading 2.5 μl and 5 μl. 
     The common reverse primer  150  (#2: SEQ ID NO:68) for second strand synthesis was resuspended to 100 μM. 
     Annealing: 
     The following reagents were combined to give a 1 μM solution in each primer (40 ng/μl combined): 
     10 μl of 100 μM primer pool C or D (SEQ ID NO:3 to SEQ ID NO:66) 
     10 μl of 100 μM reverse primer #2 (SEQ ID NO:68) 
     100 μl New England Biolabs Buffer #4 
     880 μl H 2 0 
     1000 μl total 
     A 100 μl aliquot of the above mixture was heated to 95° C., then cooled down as shown below to room temperature: 
     95° C., 2 minutes 
     80° C., 1 minute 
     75° C., 1 minute 
     70° C., 1 minute 
     65° C., 1 minute 
     60° C., 1 minute 
     55° C., 1 minute 
     Room temperature, hold. 
     A 2.5 μl and 5.0 μl aliquot of the annealed mixture was checked on an agarose gel. 
     Fill-in Reaction: 
     The annealed mixture was then treated with Klenow to fill in both strands, thus generating a population of blunt ended, double-stranded precursor molecules  230  as shown in  FIG. 4 , Step B, each having a target-specific region  202  and a common sequence region  204  for binding to a capture reagent. It will be understood by those of skill in the art that the double-stranded precursor oligo structure  230  may also be generated by synthesis of the top and bottom strands, followed by annealing of the single strands into a double-stranded structure having the desired “GG” nucleotide overhang on the first end and the desired “CC” nucleotide overhang on the second end of the molecule to facilitate head to tail concatemerization upon ligation. 
     Second strand synthesis of each of the annealed oligo mixtures “C” and D″ were carried out as follows: 
     100 μl annealed primer mixture, described above 
     1 μl 10 mM dNTPs 
     2 μl Klenow (3′ to 5′ exo-) 5000 units/ml (M0212S), New England Biolabs, MA 
     Incubated at 37° C. for 30 minutes, 75° C. for 20 minutes. A 3 μl or 6 μl aliquot of each pool was checked on an agarose gel. 
     Exemplary double-stranded capture probe precursors  230  are provided below based on the “D” series oligo for exon 1 (−35) (SEQ ID NO:3), provided in Table 1: 
     The top strand of the filled-in double stranded product (SEQ ID NO:3 annealed to Reverse primer #1 SEQ ID NO:67) is: 
     
       
         
           
               
            
               
                 (SEQ ID NO: 69) 
               
               
                 5′ CGCGAATGCC GGTGCCCGAGGCTCCCGCGACGCTCACGCGCTCCT AC   
               
               
                   
               
               
                   GCGTGGCGGATGT GGACCCCTTCGAGCAATTATAAGAATGCCGACC 
               
               
                   
               
               
                 TC 3′ 
               
               
                 (3′ flanking region: Psi1/Bsm1) 
               
            
           
         
       
     
     The bottom strand of the filled-in double-stranded product (SEQ ID NO:3 annealed to Reverse Primer #1 SEQ ID NO:67) is: 
     
       
         
           
               
            
               
                 (SEQ ID NO: 70) 
               
               
                 5′GAGGTCGGCATTCTTATAATTGCTCGAAGGGGTCCACATCCGCCACG 
               
               
                   
               
               
                 CGT AGGAGCGCGTGAGCGTCGCGGGAGCCTCGGGCACCGGCATTCG   
               
               
                   
               
               
                   CG -3′ 
               
               
                 (3′ flanking region: Psi1/Bsm1) 
               
            
           
         
       
     
     The top strand of the filled-in double-stranded product (SEQ ID NO:3 annealed to Reverse Primer #2 SEQ ID NO:68) is: 
     
       
         
           
               
            
               
                 (SEQ ID NO: 71) 
               
               
                 5′ CGCGAATGCC GGTGCCCGAGGCTCCCGCGACGCTCACGCGCTCCT AC   
               
               
                   
               
               
                   GCGTGGCGGATGT GGACCCCTTCGAGCAATTAAGCTTGAATGCCGACC 
               
               
                   
               
               
                 TC-3′ 
               
               
                 (3′ flanking region: HindIII/Bsm1) 
               
            
           
         
       
     
     The bottom strand of the filled-in double stranded product shown is: 
                    (SEQ ID NO: 72)       5′GAGGTCGGCATTCAAGCTTAATTGCTCGAAGGGGTCCACATCCGCCA               CGCGT AGGAGCGCGTGAGCGTCGCGGGAGCCTCGGGCACCGGCATTCG                   CG -3′       (3′ flanking region: HindIII/Bsm1)            
Digestion with Bsm1 to Generate Ligation Substrates:
 
     As shown in  FIG. 4 , Step B, the filled-in double-stranded capture probe precursors  230  were then digested with Bsm1 to generate ligation substrates as follows: 
     2 μl of Bsm1 (10,000 units/ml, R0134S, New England Biolabs) was added to each of the 100 μl heat inactivated fill-in reactions and incubated at 65° C. for 1 hour. 3 μl and 6 μl of each pool was checked on an agarose gel. The Bsm1 digests were then purified over a QIAQUICK column (Qiagen), eluted and quantified by nanodrop. 
     Resulting exemplary double-stranded oligonucleotide structures after Bsm1 digestion, as illustrated in  FIG. 4 , Step B: 
     The top strand of the Bsm1 digested double-stranded oligo (SEQ ID NO:69/SEQ ID NO:70) is: 
     
       
         
           
               
            
               
                 (SEQ ID NO: 73) 
               
               
                 5′GGTGCCCGAGGCTCCCGCGACGCTCACGCGCTCCT ACGCGTGGCGGA   
               
               
                   
               
               
                   TGT GGACCCCTTCGAGCAATTATAAGAATGCC 3′ 
               
               
                 (3′ flanking region: Psi1) 
               
            
           
         
       
     
     The bottom strand of the Bsm1 digested double-stranded oligo (SEQ ID NO:69/SEQ ID NO:70) is: 
     
       
         
           
               
            
               
                 (SEQ ID NO: 74) 
               
               
                 5′CATTCTTATAATTGCTCGAAGGGGTCCACATCCGCCACGCGT AGGAG   
               
               
                   
               
               
                   CGCGTGAGCGTCGCGGGAGCCTCGGGCACCGG 3′ 
               
               
                 (3′ flanking region: Psi1). 
               
            
           
         
       
     
     The top strand of the Bsm1 digested double-stranded oligo (SEQ ID NO:71/SEQ ID NO:72) is: 
     
       
         
           
               
            
               
                 (SEQ ID NO: 75) 
               
               
                 5′GGTGCCCGAGGCTCCCGCGACGCTCACGCGCTCCT ACGCGTGGCGGA   
               
               
                   
               
               
                   TGT GGACCCCTTCGAGCAATTAAGCTTGAATGCC 3′ 
               
               
                 (3′ flanking region: HindIII) 
               
            
           
         
       
     
     The bottom strand of the Bsm1 digested double-stranded oligo (SEQ ID NO:71/SEQ ID NO:72) is: 
                    (SEQ ID NO: 76)       5′CATTCAAGCTTAATTGCTCGAAGGGGTCCACATCCGCCACGCGT AGG                   AGCGCGTGAGCGTCGCGGGAGCCTCGGGCACCGG 3′       (3′ flanking region: HindIII)            
Ligation of Bsm1 Digested Precursors to Form Head-to-Tail Concatemers:
 
     As shown in  FIG. 4 , Step C, the Bsm-1 digested products  230  were then used as ligation substrates to generate a series of head-to-tail concatemers  240  for use as amplification templates. 
     Ligation was carried out as follows: 
     The following reagents were combined for each pool “C” and “D”: 
     50 μl 2× quick ligase buffer (New England Biolabs) 
     11 μl of 48 ng/μl Bsm1 digested pool C or D 
     34 μl H 2 O 
     5 μl ligase (New England Biolabs) 
     100 μl total 
     Incubated at room temperature for ≧10 minutes. A no DNA control (no template) was also prepared. 
     As illustrated in  FIG. 4 , Step C, it is noted that the ligation reaction naturally drives towards the formation of circularized templates due to the fact that in very dilute solutions of free ends, the probability of self-ligation (circularization) becomes higher than the probability of finding a separate free end. 
     Amplification of Head-to-Tail Concatemers: 
     As shown in  FIG. 4 , Step D, circularized concatenated DNA was then amplified by greater than 1000 fold (i.e., 10,000 fold to 20,000 fold) to form amplified concatemers  260  by using a random amplification primer  250  with the strand displacement polymerase technology found in the TEMPLIPHI isothermal amplification kit (GE Life Sciences, Piscataway, N.J.). 
     The random amplification primer  250  used in this Example was a random 7-mer amplification primer with an additional two nitroindole residues at the 5′ end and a phosphorothioate linkage at the 3′ end: 5′[nitroindole]2-[N]6-(phosphothioate)-N (SEQ ID NO:77, wherein the “N” at positions 1-7 may be A, G, C or T), as described by Lage et al., Genome Res 13:294-307 (2003), incorporated herein by reference. 
     Isothermal Amplification: 
     Four reaction mixtures of “C” pool and “D” pool ligations were prepared as follows, along with 2 reaction mixtures of a “no template” control: 
     25 μl of 100 μM amplification primer [5-nitroindole]2-[N]6-(phosphothioate)-N (SEQ ID NO:77) 
     10 μl ligated template “C” or “D” pool (or no template control) 
     5 μl 10× phi29 buffer (New England Biolabs) 
     10 μl H 2 0 
     50 μl total 
     The above reagents were mixed and incubated at 95° C. for 3 minutes, then cooled to room temperature, then 50 μl of the following enzyme premix was added: 
     Enzyme Premix: 
     25 μl of 100 μM amplification primer (SEQ ID NO:77) 
     10 μl H 2 0 
     5 μl 10× phi29 buffer (NEB) 
     4 μl 10 mM dNTPs 
     2 μl 100 mM DTT 
     2 μl 10 mg/ml BSA (NEB) 
     2.5 μl phi29 polymerase (NEB) 
     50 μl total volume of enzyme premix 
     The 50 μl annealed mixture was combined with the 50 μl enzyme premix, then incubated at 30° C. for 12 hours. The polymerase was inactivated by incubation at 65° C. for 10 minutes, then cooled to 4° C. The mixture was briefly centrifuged to pellet the protein and the supernatant was transferred to a fresh tube. 
     The isothermal amplification reactions were then ethanol precipitated by combining the four “C” reactions and the four “D” reactions (separately), then adding 600 μl TEzero, split into two tubes of 500 μl each, then adding 120 μl 3M NaOAc at pH 5.2 to each tube, then 1200 μl ethanol. The reactions were centrifuged for 10 minutes at 12K RPM and the pellets were resuspended in 880 μl TEzero. The amount of DNA recovered was quantitated. The yield was determined to be 65 to 79 ng/μl for all four tubes, therefore, each 100 μl isothermal amplification reaction produced 28.5 to 30 μg of DNA, which was an unexpectedly high yield. It is noted that the isothermal amplification reaction carried out with 50 μM of the random amplification primer [5-nitroindole]2-[N]6-(phosphothioate)-N (SEQ ID NO:77) in combination with 400 nM dNTPs and DTT as described above provided reaction conditions that yielded a significantly higher amount of amplification product than was obtained from an amplification reaction with the same templates using the reagents from a commercially available kit (GE Healthcare Life Sciences). 
     It is noted that an initial attempt was made to simply ligate dsDNA blunt-end oligonucleotide probes together followed by amplification (Series “B” pool). However, it was determined that this initial approach was not suitable for uniformly amplifying a population of probes for solution-based capture because the oligonucleotides were ligated in random head to tail, head to head and tail to tail orientation. In the head to head and tail to tail orientations some common tail sequences hybridized together, thereby creating a snap-back stem in ssDNA. These ssDNA stem regions were poisonous to polymerases, resulting in under-representation of amplified products. 
     Digestion of Amplified Concatenated Strands into Monomer Double-Stranded Capture Probe Precursors: 
     As shown in  FIG. 4 , Step E, the amplified concatenated strands  260  were then cleaved into monomer double-stranded capture precursors  270  with Bsm1 and 5′ terminal phosphates were removed with Antarctic Phosphatase, as follows: 
     Digestion with Bsm1 after Isothermal Amplification: 
     55 μg from each amplification reaction was digested with 20 μl Bsm1 in a total volume of 1 ml in 1×NEB Buffer #4 buffer at 65° C. for two hours. After the two hour digestion, an aliquot of each digest was checked on an agarose gel. The majority of the “C” and “D” digested pool showed the expected 90 bp product, with a small amount of 130 bp product. 
     Phosphatase Treatment: 
     110 μl 10× Antarctic Phosphatase buffer (NEB) was added to the Bsm1 digested pool C and D. 50 μl Antarctic phosphatase was added (NEB), and incubated for one hour at 37° C. then 65° C. for 15 minutes. An aliquot of 10 μl was taken out of each sample, then the samples were ethanol precipitated. 
     After ethanol precipitation, each sample was split into four tubes of 250 μl each to which was added: 250 μl TEzero, 120 μl of 3M NaOAc pH5.2, 2 μl glycol and mixed. 1200 μl ethanol was added per tube, mixed, precipitated and centrifuged at 12K RPM, 10 minutes. 
     Digestion With Psi1 or HindIII to Liberate the Precise 3′ Ends of the Capture Probes: 
     As shown in  FIG. 4 , Step F, monomeric capture precursors and the precise 3′ ends of capture probes were then liberated by digestion with Psi1 or HindIII, which also leaves 5′ terminal phosphates on the complementary strands. 
     After the phosphatase treatment as described above, the pellets were then resuspended in 960 μl of 1×NEB #4 buffer and 40 μl PsiI, then digested for 2 hours at 37° C. The digests were then ethanol precipitated. 
     Selective Removal of the Complementary Strand of the Monomer Capture Probe Precursors to Produce a Population of Single-Stranded Capture Probes for Solution Based Capture: 
     As shown in  FIG. 4 , Step G, a population of single-strand capture probes  200  (i.e., a library), each probe  200  containing a distinct target specific region  202  and a common capture reagent binding region  204 , were generated by digesting the double-stranded monomer capture probe precursors  270  with Lambda exonuclease. Lambda exonuclease specifically degrades dsDNA by attacking at 5′ phosphate sites and selectively digests away the non-capture complementary strand, thereby converting the dsDNA into ssDNA suitable for use as capture probes. 
     Lambda Exonuclease Digestion: 
     An enzyme titration was first run with lambda exonuclease starting at a concentration of 1 μl/10 μl and diluted down in 2-fold steps. Each reaction contained 10 μg substrate (digested with Bsm1, alkaline phosphatase and Psi1) in 100 μl and were digested at 37° C. for 10 minutes, 75° C. for 10 minutes, then cooled to 4° C. The reactions were run on an agarose gel and the conditions of 10 μg substrate in 100 μl with 5 μl exonuclease for 10 minutes at 37° C. was used for subsequent digestions of the pool C and pool D substrate. 
     Scaled Up Reaction: 
     For capture series “C”, 90 μl of 89 ng/μl dsDNA precursor was digested with 5 μl lambda exonuclease in 100 μl 1× lambda exonuclease buffer (NEB). 
     For capture series “D”, 100 μl of 208 ng/μl dsDNA precursor was digested with 5 μl lambda exonuclease in 200 μl 1× lambda exonuclease buffer (NEB). 
     The following is an exemplary structure of a final single-stranded capture probe  200  resulting from the capture probe precursor SEQ ID NO:69/70 or SEQ ID NO:71/72 after processing with lambda exonuclease: 
     
       
         
           
               
            
               
                 (SEQ ID NO: 78) 
               
               
                 5′GGTGCCCGAGGCTCCCGCGACGCTCACGCGCTCCT ACGCGTGGCGGA   
               
               
                   
               
               
                   TGTGGACCCCTTCGAGCAATTA 3′ 3′ 
               
            
           
         
       
     
     The capture probe SEQ ID NO:78 comprises a 5′ region  202  that hybridizes to the −35 exon 1 of the AKT gene, and a 3′ region  204  (underlined) that hybridizes to a universal biotinylated oligonucleotide  300 . 
     The universal capture hybridizing region  204  of capture probe SEQ ID NO:78 is: 
                    (SEQ ID NO: 80)                         5′ ACGCGTGGCGGATGTGGACCCCTTCGAGCAATTA 3′            
Discussion:
 
     The isothermal amplification method described in this Example converted 2.5 ng (0.1 μmol) of starting material into 50 μg (2000 μmol) of raw, unprocessed double-stranded material, which is a 20,000-fold level of amplification. In comparison, the Agilent custom library array platform provides 250 ng (10 μmol) of cleaved oligonucleotide. Processing of the double-stranded DNA precursor capture probe  230  to single stranded capture probes  200  resulted in approximately 15 μg (1200 μmol) of single-stranded capture probe  200 , which is a 60% yield from the starting amplified unprocessed double-stranded material  230 . In addition to high yield of amplified products, the use of concatemers  240  as templates for amplification provides an equal distribution of amplified monomer products  270 , resulting in an equal distribution of processed capture probes  200 . The lambda exonuclease digested material (ssDNA)  200  was successfully used as a capture probe library for solution based capture of the AKT exons 1-13, as described in Example 2. 
     Example 2 
     This Example describes solution-based capture using a pool of capture probes  200  generated as described in Example 1, each capture probe  200  comprising a target specific region  202  specific for binding to one of the 13 exons of AKT (NM — 005163) and a common region  204  that hybridizes to a universal biotinylated adaptor oligo  300 . 
     Rationale: 
     As shown in  FIG. 2 , target gene enrichment of a genomic library may be achieved by indirect capture using a pool of chimeric capture ssDNA probes  200  with a first region  202  that hybridizes to a target nucleic acid sequence  10  and a second region  204  that hybridizes to a universal biotinylated oligo  300 , mixing the chimeric oligo  200 , the universal biotinylated oligo  300  and the sample containing the target nucleic acid sequence  10  under hybridizing conditions to form a tri-molecular complex (i.e.,  10 / 200 / 300 ), and using magnetic beads  400  coated with streptavidin  410  to bind to the biotinylated region  310  of the universal oligo  300  and pull out the target sequences  10  bound in the complex to the chimeric capture probes  200 , using a magnet  500 . 
     While indirect capture is described in this Example, it will be understood by those of skill in the art that solution based capture may also be accomplished through the use of ssDNA probes  200  are directly labeled. For example, the probes  200  could be directly labeled by adding a biotin, deoxygenin, fluorescein, and the like (through the use of commercially available kits), followed by the use of antibody coated beads for purification. 
     Methods: 
     ssDNA capture probes were generated as described in Example 1. For capture series “C” and “D,” the concentration of capture probe after the lambda exonuclease digestion was approximately 40 ng/μl to 50 ng/μl. 
     The following universal 5′ biotinylated oligo (capture reagent  300 ) was used in this Example: 
     
       
         
           
               
             
               
                   
               
             
            
               
                 (SEQ ID NO: 81) 
               
               
                 5′ [BioTEG] TAATTGCTCGAAGGGGTCCACATCCGCCACGCGT 3′ 
               
            
           
         
       
     
     As described in Example 1, a library of 64 ssDNA chimeric capture oligos  200  were generated that each target one of the 13 exons of AKT1 that each have a first 5′ region  202  with the identical sequence to the oligos shown above in TABLE 1, and a second 3′ region  204  consisting of the following additional sequence that hybridizes to the universal biotinylated oligo  300 : 
                    (SEQ ID NO: 80)       5′ ACGCGTGGCGGATGTGGACCCCTTCGAGCAATTA 3′.            
Capture Mixture:
 
     A master mix was prepared by combining 62.5 μl of 80 ng/μl of a genomic DNA library containing an average insert size of 100 bp flanked by a first and second primer binding site, 10 μl of 1 μM universal biotinylated oligo (SEQ ID NO:81), 125 μl 2× binding buffer (20 mM Tris pH 7.6, 0.2 mM EDTA, 2M NaCl). 
     The master mix was then combined (separately) with the following: 
     10 μl of 1 μM Maxwell 139 AKT1 set, a set of 28 directly synthesized capture oligonucleotides specific for AKT exons 1-13 (low density coverage). 
     10 μl of 1 μM “A” series high density AKT1 control set (64 oligo pool) that was directly synthesized (not amplified). Each capture probe was synthesized to contain only the target specific portion  202  and the universal oligo hybridizing portion  204 , without the flanking sequences. For example, the probe for AKT exon 1 (−35) was identical to the final processed amplified probe for AKT exon 1 (−35) (SEQ ID NO:78). 
     10 μl of processed “C” Series Capture probes (in duplicate): a set of 64 AKT capture probes generated using the amplification method described in Example 1. 
     10 μl of processed “D” Series Capture probes: a set of 64 AKT capture probes generated using the amplification method described in Example 1. 
     20 μl of processed “D” Series Capture probes, as described for Sample #4 above. 
     Each reaction was brought to a total volume of 250 μl, mixed, and annealed as follows: 
     95° C. for 5 minutes 
     80° C. for 15 minutes 
     75° C. for 15 minutes 
     70° C. for 15 minutes 
     65° C. for 15 minutes 
     60° C. for 15 minutes 
     55° C. for 15 minutes 
     Room Temperature. 
     Capture Reagents: 
     Washed streptavidin-coated magnetic beads were prepared by combining 66 μl beads (MyOne streptavidin-coated beads, InVitrogen) 500 μl 2× binding buffer and 440 μl water. 
     Capture: 
     Each of the annealed 250 μl mixtures were combined with 10 μl of washed beads in a total volume of 1 ml (10 mM Tris, pH 7.6, 0.1 mM EDTA, 1 M NaCl, 0.1% Triton X100) and incubated with mixing for 15 minutes. The beads were then washed four times, 5 minutes each, with 1 ml of TEzero wash buffer (10 mM Tris pH 7.6, 0.1 mM EDTA) containing 25% formamide. 
     Elution: 
     The DNA bound to the beads was eluted with two 25 μl aliquots of water by incubation at 95° C. for 1 minute, pulling over the beads, and removing the eluate, for a total eluate volume of 50 μl 
     Amplification of Eluate: 
     PCR Reaction Mixture (Each Sample Performed in Duplicate) 
     10 μl template (eluate from enriched fragment library) 
     30 μl H 2 O 
     20 μl 5×PCR buffer (supplied by manufacturer with the EXPAND plus ® kit, Roche) 
     10 μl 25 mM MgCl 2   
     
       
         
           
               
               
            
               
                   
                 10 μl Forward PCR primer 
               
               
                   
                 (5′-AATGATACGGCGACCACCGA-3′ (SEQ ID NO: 82)) 
               
               
                   
               
               
                   
                 10 μl Reverse PCR primer 
               
               
                   
                 (5′-CAAGCAGAAGACGGCATACG-3′ (SEQ ID NO: 83)) 
               
            
           
         
       
     
     5 μl 10 mM dNTPs 
     5 μl DMSO 
     1 μl Expand PLUS ® polymerase (Roche) 
     100 μl total volume 
     PCR Cycling Conditions: 
     1 Cycle: 
     95° C. for 2 minutes 
     10 Cycles: 
     95° C. for 30 sec 
     60° C. for 30 sec 
     72° C. for 1 minute 
     10 Cycles: 
     95° C. for 30 sec 
     60° C. for 30 sec 
     72° C. for 1 minute plus 10 sec/cycle 
     1 Cycle: 
     72° C. for 5 minutes 
     4° C. hold 
     The PCR products were purified over a QIAQUICK column, quantified and diluted to 1 ng/μl for subsequent quantitative PCR (qPCR) (Taqman) analysis. 
     Quantitative PCR Analysis: 
     The PCR products generated as described above (1 ng/μl), no template control and genomic DNA control (10 ng/μl) were used as templates in Taqman assays directed against coding exons 1-13 of AKT1. Negative controls ANKHD, PIK3CA and TP53 were also included in this assay, which should not be captured as target sequences with the AKT specific probe pools. 
     Results: 
     The results of the qPCR analysis were analyzed in two ways. First, the fold-enrichment for each solution-based capture over genomic DNA was calculated, as shown in TABLE 2. 
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 Fold Enrichment relative to genomic DNA of solution- 
               
               
                 based capture using various capture probe pools 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                 Series 
                 Series 
                   
                   
               
               
                 Targeted 
                 Maxwell 
                 Series 
                 C 
                 C 
                 Series 
                 Series 
               
               
                 AKT 
                 139 
                 A 
                 (set #1) 
                 (set #2) 
                 D 
                 D 
               
               
                 exon 
                 (10 μl) 
                 (10 μl) 
                 (10 μl) 
                 (10 μl) 
                 (10 μl) 
                 (20 μl) 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 exon 1 
                 1970 
                 1158 
                 3471 
                 3376 
                 3802 
                 6370 
               
               
                 exon 2 
                 1338 
                 931 
                 2790 
                 2895 
                 3662 
                 6450 
               
               
                 exon 3 
                 1131 
                 989 
                 2480 
                 2568 
                 3452 
                 6044 
               
               
                 exon 4 
                 1579 
                 1072 
                 2508 
                 2507 
                 4189 
                 7122 
               
               
                 exon 5 
                 1460 
                 1189 
                 3408 
                 3840 
                 5184 
                 8878 
               
               
                 exon 6 
                 1641 
                 1002 
                 3083 
                 3461 
                 4048 
                 5586 
               
               
                 exon 7 
                 1435 
                 1048 
                 3578 
                 3660 
                 4642 
                 6167 
               
               
                 exon 8 
                 1331 
                 1112 
                 2408 
                 2212 
                 3780 
                 7418 
               
               
                 exon 9 
                 1242 
                 1194 
                 3495 
                 3817 
                 4746 
                 8526 
               
               
                 exon 10 
                 1528 
                 1227 
                 3146 
                 3176 
                 4675 
                 9464 
               
               
                 exon 11 
                 1314 
                 1103 
                 2592 
                 2638 
                 3741 
                 6904 
               
               
                 exon 12 
                 1478 
                 960 
                 1964 
                 2511 
                 3739 
                 6862 
               
               
                 exon 13 
                 1662 
                 1107 
                 754 
                 648 
                 4236 
                 6504 
               
               
                 ANKHD 
                 1 
                 1 
                 1 
                 0 
                 0 
                 1 
               
               
                 PIK3CA 
                 0 
                 0 
                 0 
                 0 
                 0 
                 0 
               
               
                 TP53 
                 0 
                 1 
                 1 
                 0 
                 0 
                 1 
               
               
                   
               
            
           
         
       
     
     Second, the standard deviation of the exon-to-exon capture efficiency was calculated as a percent of the overall fold-enrichment, as shown below in TABLE 3. This latter number provides a measure of the uniformity of each capture reaction. 
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 Standard deviation of the exon-to-exon capture efficiency 
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                 Series 
                 Series 
                   
                   
               
               
                   
                 Max 
                 Series 
                 C 
                 C 
                 Series 
                 Series 
               
               
                   
                 139 
                 A 
                 (set #1) 
                 (set #2) 
                 D 
                 D 
               
               
                   
                 (10 μl) 
                 (10 μl) 
                 (10 μl) 
                 (10 μl) 
                 (10 μl) 
                 (20 μl) 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 Average fold 
                 1470 
                 1084 
                 2745 
                 2870 
                 4146 
                 7100 
               
               
                 enrichment 
               
               
                 for AKT 
               
               
                 exons 1-13 
               
               
                 standard 
                 216 
                 94 
                 782 
                 863 
                 523 
                 1175 
               
               
                 deviation of 
               
               
                 exon-to-exon 
               
               
                 capture 
               
               
                 efficiency 
               
               
                 Percent 
                 15% 
                 9% 
                 28% 
                 30% 
                 13% 
                 17% 
               
               
                 deviation, 
               
               
                 expressed as 
               
               
                 a percentage 
               
               
                 of the fold- 
               
               
                 enrichment 
               
               
                   
               
            
           
         
       
     
       FIG. 6  graphically illustrates the fold of enrichment of the target AKT exons 1 to 13 (shown on the x-axis) relative to genomic DNA of solution-based capture using 100 of each of the following probe pools: the “Maxwell 139” capture probe pool (low density, directly synthesized oligonucleotides), the “Series A” capture probe pool (high density, directly synthesized oligonucleotides) and the “Series D” capture probe pool (high density, generated via amplification of head-to-tail concatemers). As shown in  FIG. 6 , the fold enrichment using the Series D capture probe pool was at least as good as the fold enrichment using the Series A capture probe pool. 
     Discussion: 
     The “A” series oligos were directly synthesized 69 mers (non-amplified) containing the identical sequence as the probe sequences generated after processing amplified sequences. The “C” series oligos were initially synthesized as 79mers, annealed to a reverse primer, filled-in, digested with Bsm1, ligated into concatemers, amplified, digested back to monomers, and lambda-exo treated to generate ssDNA probes. The “D” series oligos were initially synthesized as 60mers (less overlap with reverse primer than the “C” series), annealed to a reverse primer, filled-in, digested with Bsm1, ligated into concatemers, amplified, digested back to monomers and lambda-exo treated to generate ssDNA probes. It is important to note that the “D” series oligos are the least expensive to generate due to the fact that they can be made on a 50 nmole synthesis scale due to their smaller size. As described above in Example 1, the amplification of the capture probe pool “C” or “D” was observed to be in the range of 10,000 to 20,000 fold amplification, thereby facilitating the cost-effective use of solution based capture for target enrichment in a variety of applications. 
     It is noted that the absolute magnitude of the fold-enrichment shown in TABLE 2 may be exaggerated because the critical stoichiometry between the capture oligonucleotides and the common, biotinylated adaptor capture reagent oligonucleotide was not optimized in this experiment. However, the key metric is that the standard deviation of exon-to-exon capture efficiency, expressed as a percentage of the fold-enrichment, as shown in TABLE 3 and  FIG. 6 , was essentially identical for the synthetically generated capture probes (Series A=9%) versus the capture probes generated using the amplification methods described in Example 1 (Series D=13%). 
     Agarose gel analysis of the capture probes generated by the amplification methods described herein showed that they formed bimolecular complexes during solution based capture that were indistinguishable from the biomolecular complexes formed with directly synthesized capture probes. Importantly, as demonstrated in TABLES 2 and 3 and  FIG. 6 , the solution based capture of the 13 exons of the AKT gene with the capture reagent generated by amplification worked at least as well as control reactions performed with directly synthesized capture probes. This conclusion is based on the metrics of fold-enrichment and on the standard deviation of exon-to-exon enrichment as a percentage of the overall fold-enrichment. 
     Therefore, this Example demonstrates that the capture probes generated from amplified head-tail concatemers may be successfully used for solution based capture, and provide an advantage in targeted resequencing by reducing the cost of resequencing while increasing the feasibility of profiling applications that are dependent on complex oligonucleotide libraries. 
     Example 3 
     This Example describes a method for designing and uniformly amplifying a library of target capture probes designed to capture the entire collection of exons that include protein coding regions from a human genomic DNA library. 
     Rationale: 
     As described in Examples 1 and 2, a method for uniformly amplifying a library of synthesized capture oligonucleotides for use in solution based capture methods can be applied to capture all the exons of a gene, such as AKT. This Example demonstrates that the methods described herein can be applied on a very large scale, in order to generate a library of capture probes that capture the entire collection of genomic segments that include all protein coding regions from a human genomic library. 
     Methods: 
     Design of Capture Probe Oligonucleotide Precursors for Amplification and Processing into a Library of Capture Probes: 
     As shown in  FIG. 4 , step A, the general structure of the double-stranded capture probe precursor includes a 5′ flanking region  210  comprising a first restriction enzyme site for creating a first nucleotide overhang for ligation (e.g., Bsm1), a capture probe region  200  comprising a target specific hybridizing region  202  and a universal capture oligo hybridizing region  204 , and a 3′ flanking region  220  comprising a second restriction enzyme site (e.g., Bsm1) for creating a second nucleotide overhang for ligation, and further comprising a third restriction enzyme site (e.g., Psi1 or HindIII), for precisely cleaving off the 3′ flanking region. 
     Design of the Target-Specific Region  202  of the Capture Probe  200 : 
     In this Example, a capture probe library  200  comprising 1,148,286 distinct target-specific regions  202  was generated for high density solution based capture of the entire collection of genomic segments that include protein coding regions (exons) for 25,341 annotated human genes. 
     The overall design principles for designing a capture probe library  200  comprising target-specific regions  202  for capture of all the exons of 25,341 human genes were as follows. Each target-specific region  202  was 35 nucleotides in length. The target-specific region was designed such that each target exon had at least 4 or more probes (high density), and the capture probes alternated in strand orientation and were oriented in a head to tail arrangement, with oligo probes alternating with respect to hybridizing to the coding or non-coding strand of the target exon. 
     In this Example, the term “candidate oligonucleotide” refers to a 35mer nucleotide sequence that was analyzed for potential use as target-specific region in a capture probe, to determine whether the candidate oligonucleotide sequence met the desired criteria, as described below. The 35mer nucleotide sequences that met all of the design criteria outlined herein were chosen as the set of target-specific regions  202  and were synthesized on a microarray along with flanking sequences to generate an oligonucleotide library having 1,148,286 distinct target-specific regions. 
     Step 1: Obtain Input Sequence: 
     In order to design the target-specific sequences of the library of capture probes, the genes and transcripts of interest were first identified. In this Example, the entire list of human high quality mRNA transcripts provided in the publicly accessible NCBI database “RefSeq NM transcripts” was selected as input sequence, which was a total of 25,341 human annotated mRNA transcripts. The protein coding exons in the 25,341 input human mRNA transcripts were then identified using the publicly accessible “UCSC Genome Browser” database. The UCSC Genome Browser is developed and maintained by the Genome Bioinformatics Group, a cross-departmental team within the Center for Biomolecular Science and Engineering at the University of California Santa Cruz. Once the protein coding exons were identified, the genomic sequences of interest plus 100 nucleotides of adjacent intronic sequences on either side of the exons were extracted. Overlapping regions were then identified and removed from the list of sequences by using genomic coordinates. For overlapping regions that were identified, the sequence that was retained was based on the 5′ most and 3′ most genomic coordinates between all the pairs of exons in the overlapping region. 
     Step 2: Upfront Sequence Classification: 
     The list of sequences generated as described in Step 1 was then searched using the software program “repeatmasker” to identify, but not mask, the repeat and low complexity elements. 
     Step 3: Determination of Uniqueness Score of Candidate Oligonucleotide Probe Sequences: 
     The uniqueness of all 35mer sequences in the sequenced human genome relative to the human genome was determined as follows. First, the “UCSC Genome Browser” database was used to extract every 35mer sequence from the sequenced human genome. Second, the software algorithm “Burrows-Wheeler Alignment” (hereinafter referred to as “BWA”) was used to align (i.e., blast) these 35mer sequences against the entire sequenced human genome. BWA is a fast light-weighted tool that aligns short sequences to a sequence database, such as the human reference genome. For each 35mer candidate oligo sequence, BWA returned an alignment score that measures the confidence in the identified location, as described in Li, H., et al.,  Genome Res.  18(11):1851-8 (2008), incorporated herein by reference. The alignment score provided by BWA is a −log 10 p-value, ranging from 37 (unique in the genome) to 0 (multiple perfect matches). Intermediate values reflect alignments that are similar but not 100% (e.g., with one nucleotide mismatch). 
     Step 4: Final Selection of the Target-Specific Regions  202  for Synthesis to Generate a Library of Capture Probes  200  for Total Exon Capture of the Human Genome: 
     The final selection of the 1,148,286 distinct target-specific regions for synthesis in order to generate a library of capture probes  200  that hybridizes to all the exons of 25,341 annotated genes was carried out as follows. 
     For each target exon at least 140 nucleotides or longer, analysis for candidate oligos began at the 5′ edge of the exon. For target exons 140 nucleotides or shorter, the analysis began in the 5′ intron such that the candidate oligos were equally spaced at the exon center. 
     From the starting position, each candidate oligo location was then “jittered” by shifting the region of analysis by +/−4 nucleotides as follows. The nucleotide sequence of the candidate oligo closest to the desired location was first examined, and the examination of candidate oligos was carried out by shifting the region of analysis in the order: +1, −1, +2, −2, +3, −3, +4, −4. The +/−4 nucleotide range was chosen because a wider range (more “jitter”) may allow oligo dimers to form with adjacent oligos, which would be undesirable. 
     The best candidate oligos from each “jittered” position were then selected based on the following criteria. First, the BWA alignment score (uniqueness) of the candidate 35mer capture oligo sequences was maximized relative to the entire genome (wherein 37=unique and 0=multiple perfect matches). Second, among the candidate 35mer capture oligo sequences with the same BWA alignment score, the number of repeat/low-complexity nucleotides contained in the 35mer sequence was minimized. 
     The nucleic acid sequences of the 1,148,286 distinct target-specific 35mer regions were output as a text file to an oligonucleotide synthesis platform and synthesized. 
     In this Example, the target-specific regions were flanked by a 3′ flanking region (SEQ ID NO:1) for annealing to a common reverse primer for second strand synthesis, and by a 5′ flanking region (SEQ ID NO:2) which provides at least one processing site for ligation and amplification, resulting in a structure corresponding to the single-stranded capture probe precursor  100  as illustrated in  FIG. 4 , Step A, and described in Example 1. The processing of the library of capture probe precursors  100  to double-stranded precursors  230 , processing of the 5′ and 3′ flanking regions to generate ligation substrates, ligation into head-to-tail concatemers, amplification and processing of the amplified head-to-tail concatemers to form monomers, and selective removal of the non-capture complement strand of the monomers to form a library of single-stranded capture probes, is carried out as described in Example 1. 
     TABLE 4 below provides the sequence information and scores from the selection criteria described above for a representative, randomly chosen subset of 2170 capture probe precursors from the total library of 1,148,286 capture probe precursors that were synthesized. 
     In particular, TABLE 4 provides the following information: Column 1: gene name; Column 2: Genbank transcript reference number; Column 3: target exon number; Column 4: the chromosome of the target exon; Column 5: the gene strand; Column 6: the distance of the capture probe from the 5′ edge of the target exon; Column 7: the strand of the capture probe; Column 8: the number of repeat nucleotides; Column 9: the BWA alignment score (wherein 37=unique and 0=multiple perfect matches); Column 10: the number of hits from the BWA alignment (1=unique); Column 11: the number of hits from BWA mismatch (0=no mismatch; 1=mismatch); Column 12: the sequence of the single-stranded precursors, each including the common 5′ flanking region (SEQ ID NO:2) and common 3′ flanking region (SEQ ID NO:1); and Column 13: the SEQ ID NO: from SEQ ID NO:84 to SEQ ID NO:2253. 
     As shown in TABLE 4, Column 9, a score of “1” for the “number of hits from the BWA analysis corresponds to a uniqueness score of a perfect 37, in which capture oligo sequence only recognizes the intended target. 
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                 Representative subset (2170) of a total of 1,148,286 Capture Probes Designed for Exon Capture of 25,341 Human 
               
               
                 Genes 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                 Distance 
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                   
                   
                 Gene 
                 from exon 5 
                 Oligo 
                 # repeat 
                 BWA 
                   
                 # BWA 
                   
                 SEQ ID 
               
               
                 Gene 
                 Transcript 
                 Exon 
                 Chromosome 
                 strand 
                 edge 
                 strand 
                 nucleotides 
                 score 
                 BWA hit 
                 mismatch 
                 Sequence with add-ons 
                 NO: 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
               
               
            
               
                 KSR2 
                 NM_173598 
                 15 
                 12 
                 − 
                 −35 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCTGTGTAACAGGCTGTTCTCT 
                 84 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTCTCTGTAGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 15 
                 12 
                 − 
                 0 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATCTGCGGGGACCAGCGTGGCA 
                 85 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGACAGTGTGTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 15 
                 12 
                 − 
                 35 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCGCAGAGATCTCGGCAACTC 
                 86 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATCAAGCACAGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 15 
                 12 
                 − 
                 70 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGTAGGCACCAGTGCACACAGG 
                 87 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATCCAGCCTACACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 13 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCTGGCCCAGCTGCTGCCGCTC 
                 88 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGCACGGCAATACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 13 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGAACTCCCGGATGATGACCTT 
                 89 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTCCCGTTCACACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 13 
                 19 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGCACTGCCGCCGGGGACTGC 
                 90 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAGCAACCACAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 13 
                 19 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGGTAGGTGGTGGAGGGGCTCC 
                 91 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCGGGCTGCCGGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 13 
                 19 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACACCCCCACCCCCAGCGAGGA 
                 92 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCCGCCATCCCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 13 
                 19 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCGGAAATGAGCCGCTTGAGC 
                 93 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGGACTTAGAGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 13 
                 19 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTCAGTGTATGAGAAGCGGCCT 
                 94 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACTTCAGGATGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 13 
                 19 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGCTCTGTAGCACCTGCGGGTG 
                 95 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACGTACCAGCAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 13 
                 19 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGCAGGAGCACCTGCCCGTGC 
                 96 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGTGCCAGTGGAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 13 
                 19 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCTTTGGGGGCCGAGGGCACCG 
                 97 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGTCACATAGCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 13 
                 19 
                 + 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACAGTGGCAGCGTCCCCTCCAC 
                 98 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGGCCCAGCCAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 13 
                 19 
                 + 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGCTGACTTCCTCTTCAGCGAG 
                 99 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGGGAGTGCCCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 13 
                 19 
                 + 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGCATGTGCATCACCCATTC 
                 100 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGAAGAAGCGCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 13 
                 19 
                 + 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCTGCCCACCCCACCTCACCTG 
                 101 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCGTCGTGCCTACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 15 
                 18 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGAAGAAAGAAAAATGAATGA 
                 102 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGCTTGGAAGATACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 15 
                 18 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATTCATACTCTTCATGTGTTGTC 
                 103 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGATCAAACATACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 15 
                 18 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGTTTGGCAGACAGTTTCTCCCA 
                 104 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCAGCAGATGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 15 
                 18 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGTTTCTTTGTGGCAGTAGACA 
                 105 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTCCTCCTCTTACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 15 
                 18 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACAGTAAGATTTTTTTCTGTTTA 
                 106 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTATGGCTTCACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 17 
                 18 
                 + 
                 −22 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTAATTCATTTTTCCCCCAGAG 
                 107 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGACTAGCTTGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 17 
                 18 
                 + 
                 13 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTTTCCGAACCACCTCAATATGA 
                 108 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAAAATTTTGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 17 
                 18 
                 + 
                 48 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGAGGAGAGAAGAAAACTGCTT 
                 109 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGCACACGTGTAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 17 
                 18 
                 + 
                 83 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTATCTACATTAGTACTTACAA 
                 110 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTCACATTCCTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 8 
                 4 
                 + 
                 −12 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTTTTTAAAAGGTATCGAAGCA 
                 111 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATTAAAGCTGAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 8 
                 4 
                 + 
                 23 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTATAATGGCCACTGTCTTCTTC 
                 112 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTAGCACGGAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 8 
                 4 
                 + 
                 58 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTGTAGCTCAAAATGAAGATGC 
                 113 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTGAAGAGCTAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 8 
                 4 
                 + 
                 93 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCTTTACATACCTTGAGTTAACA 
                 114 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTCAAAAGTAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 17 
                 13 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAGTACATCTCAGAATCTTGAT 
                 115 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTGGAACAGATACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 17 
                 13 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAATTAAGCACATTCAGAATCCA 
                 116 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGGAAAGACAAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 17 
                 13 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAAGCCTTTGATTTTTACAAAG 
                 117 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGATCGAAAGTTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 17 
                 13 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATTTCTCTTGTCAAGTTGCCTTC 
                 118 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCTTTGATAAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 17 
                 13 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATAAAACATTTAGAACGATGTGA 
                 119 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACATCGAATCATACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 17 
                 13 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTAGCTACTTACTGAGAGCCAT 
                 120 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAAGGGATTCCACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_182644 
                 7 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGGAACAAGAAACAAGTTATAC 
                 121 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATTCTGAGGGCACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_182644 
                 7 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTTGAGGCTACTGATGGTAACA 
                 122 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTGTGCCTCTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_182644 
                 7 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGACACTATATACGTATTCCAA 
                 123 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCCGAGCCCGAACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_182644 
                 7 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACTTGCGGCTGTTCGTCCCATAT 
                 124 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAGCGGCTGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_182644 
                 7 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAGTTTGAAACTAGTCCAGACT 
                 125 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTATGTATTATTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_182644 
                 7 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAAGATCCCTGCCCCCTCCTCT 
                 126 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGACTGCATTGAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 2 
                 10 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCATTGGGCCTCTACTTCTCGA 
                 127 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGATGCTTACACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 2 
                 10 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGCCGGCTGCCTGGTCCACATA 
                 128 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGCTTCTCCCAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 2 
                 10 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCCTTGCTGTACGTCCATGCCCT 
                 129 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCGGGACGCCCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 2 
                 10 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGCTGGCCCAGGCGGAAGCTGG 
                 130 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCACCTCCTCAGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 2 
                 10 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCTACGGCACGTACCGCACACG 
                 131 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTGCATGAGAAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 2 
                 10 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGGCCGGTGTCCTCCTGGATG 
                 132 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGATCCAGTTGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 2 
                 10 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTACCTTAACCGGAGCCTGGAC 
                 133 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATAGCTCCTGGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 2 
                 10 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGGCGGCTCCCTTACTGCGGAC 
                 134 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTGAGCTTCTCACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 10 
                 3 
                 + 
                 −8 
                 + 
                 0 
                 0 
                 2 
                 0 
                 CGCGAATGCCTTTTACAGAGTAACAGACTAGCT 
                 135 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAGACAATGAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 10 
                 3 
                 + 
                 27 
                 − 
                 0 
                 0 
                 2 
                 0 
                 CGCGAATGCCATTGCTTTGAGCTGTTCTTTGTCA 
                 136 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTTCCCTTAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 10 
                 3 
                 + 
                 62 
                 + 
                 0 
                 23 
                 1 
                 1 
                 CGCGAATGCCTTCTACACGAGATCCTCTCTCTGA 
                 137 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATCACTGAGCACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 10 
                 3 
                 + 
                 97 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACTTACCTGTGACTCCATAGAA 
                 138 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATCTTTCTCCTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 11 
                 4 
                 + 
                 −22 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCTCTCTCTCTTGTCACGTAGCC 
                 139 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGCGTTCTGAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 11 
                 4 
                 + 
                 13 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAACAGCACCAGGACTGCAGCA 
                 140 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCACCGTGAGTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 11 
                 4 
                 + 
                 48 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGATTGTGATCATCTCACTTATTG 
                 141 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCTGGTTGTCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 11 
                 4 
                 + 
                 83 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGTTTTATGAGAAAATATCTAC 
                 142 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGTTTCCAAATACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 4 
                 4 
                 + 
                 −50 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGAAGCCTCACAGTTTCTTTTG 
                 143 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTTCTGTTTGTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 4 
                 4 
                 + 
                 −15 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGAAGGTATGGGCCATCTGCTA 
                 144 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAACAAAAACAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 4 
                 4 
                 + 
                 20 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATATTAGAGCAACCTAAACAGGT 
                 145 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGATTAAAGGGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 4 
                 4 
                 + 
                 55 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATTAGACACTGGAATCTAACAT 
                 146 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTAAAGTCCCACACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 9 
                 2 
                 − 
                 −13 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTTATCACTCAGGTGTAAGAAC 
                 147 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATATGTGGACCCACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 9 
                 2 
                 − 
                 22 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCGCACTGCTTGGTTGGGATCTT 
                 148 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGTACGTAAAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 9 
                 2 
                 − 
                 57 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTTTGCCAAAGAAATTGACGCA 
                 149 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCTGCATTAAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 9 
                 2 
                 − 
                 92 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCAGACACTTACCAACTCCTAT 
                 150 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACTTTTTCAATACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 4 
                 16 
                 − 
                 −12 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTTAATTACAGAGGCAAAGAAA 
                 151 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCAATTTTTGAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 4 
                 16 
                 − 
                 23 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCAGCAAAAGTTAGTATAGTCT 
                 152 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTCAGGGGGCAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 4 
                 16 
                 − 
                 58 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCCAAGGGATGCAAGAAGCTCT 
                 153 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTTGGTACTACACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 4 
                 16 
                 − 
                 89 
                 − 
                 11 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCTTACCAAATAACAATGTTGT 
                 154 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCATAATAGTAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGGAAGAGATCAGTGGTGTGGA 
                 155 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAACATTACACACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCATGACATTGCACACCTGGTAA 
                 156 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCCTGATGGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCACAGTCAAAACAATTGGCTG 
                 157 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAACAAACTGGACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCACATAAATCTTCTGAGCTGA 
                 158 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTCCTGGGGACACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTCAAGTTCACTCTACGAGACT 
                 159 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAATAGCATTCACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTGAATGTCTCCTTGCAAGTTCC 
                 160 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAAAACCAATGACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGTACTACATGGAGTCTGATGA 
                 161 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGATCATGGGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTCAATCTTTGTAAACTGATGCT 
                 162 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCGAAATTTCACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCATTGCAGCTGATGAAAGTTTC 
                 163 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTCAAATGGATACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCTCAGTGTTGAGCTTCAGAAT 
                 164 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACGGTCCCCAAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGAGAAGTAGGTCCTGTCAACA 
                 165 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAAGGGATTTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCAACACAAGCACCAACATCTT 
                 166 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAATGCCAAATACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGGTGTCTGTGAGAGTATACTTC 
                 167 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAAGTGCCCACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTCTGGAAACATAGCCAGATTC 
                 168 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCACTGTAAATACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 490 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGTACCCATGGACTCCCAGTCC 
                 169 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGGTGGAGGTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 525 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTTCCTCCTTAGAATTGTTGACA 
                 170 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAGACCCTCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 560 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCTCCAAGGATGTACTGCAGTA 
                 171 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGAAGGCGAATACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 595 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCATTGCAGGAACACTTGCCAA 
                 172 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGGTACAAGCCACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 3 
                 3 
                 + 
                 630 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCTATGAAGAAAGAGGTTTTAT 
                 173 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGCCAAGGTAAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 13 
                 12 
                 − 
                 −32 
                 + 
                 6 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATCCATCTTTCTCTCTCTTTATCT 
                 174 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCTCAGGTTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 13 
                 12 
                 − 
                 −1 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCTTCTTTGGTGCATTTGTTGTG 
                 175 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCACTTTAACCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 13 
                 12 
                 − 
                 34 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCACCCTGTCATCTTCTGATCATC 
                 176 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACCGAGGAGGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 13 
                 12 
                 − 
                 69 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCCTGCCCCTAGGGCAGTAAGT 
                 177 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTAAATAGTTAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 2 
                 15 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGGGAGGACACACCATGCTCCC 
                 178 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATTCGCTGGATACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 2 
                 15 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGTGAACTTCCGGTACATGATG 
                 179 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTTCAGGAGGCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 2 
                 15 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGAGAGTGATGTATGGAGCTTC 
                 180 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGGTGATCCTCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 2 
                 15 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACCATGGCTGCTTTCCATAGGT 
                 181 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAGATCTCCCAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 2 
                 15 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAACTCTCAAACACGGAGGTAA 
                 182 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAGGGGGTGCGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 4 
                 1 
                 + 
                 −29 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGCCCTGCTTCCTGCTCTGCCTT 
                 183 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCAGGTCTTCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 4 
                 1 
                 + 
                 6 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCCCACTGTCAGGCCGGGTGAC 
                 184 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTCCGCACCAGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 4 
                 1 
                 + 
                 41 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTGTATGCTATGAAGGTGCTGA 
                 185 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAAGGCAACGCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 4 
                 1 
                 + 
                 76 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTCTGCACAGGGAGGTGTCCCC 
                 186 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTCACCTTTCAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 7 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGACCCTGGAGGTACGAGTGGTG 
                 187 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCTGCAGAGACACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 7 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGGGGGTAGGGTTCCACGGGAT 
                 188 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTCTCTGGGAGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 7 
                 19 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATGGGGGGACCTGGGACCCCAG 
                 189 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAGCCGCCCCCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 7 
                 19 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGTAAAGGCCCCGGGCTGGGC 
                 190 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCTCAGGAAGGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 7 
                 19 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGAAGCGGAAGCCTCAGTGGCCG 
                 191 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGCAGCCTCAAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 7 
                 19 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACGATGCCCACTCACTGGTGTTC 
                 192 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCGGCTTCTGCTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 16 
                 12 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCCAAGAAGAAGAGCAAACCC 
                 193 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGAACCTCAAGAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 16 
                 12 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGGATGTTCTCGCAGCTGCCTA 
                 194 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGCTGCTGTGGAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 16 
                 12 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCAGCAGCGCTCCCCGCTGCT 
                 195 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCCGAGCGCTCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 16 
                 12 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAAAGGTGCGTGTCCCACAAAG 
                 196 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGGAGCGGAGGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 16 
                 12 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCCTTCCACCCCTCCTGTTCACA 
                 197 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGAGGCCAACACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 16 
                 12 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTGCAGCCCGGCAGGGTGACTT 
                 198 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTTGCAGAGAAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 4 
                 19 
                 + 
                 −42 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAAATAACCCGTGTTTAAAGAT 
                 199 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAACGTCTTCTGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 4 
                 19 
                 + 
                 −7 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGAGCCTTTGACGAATTTCTTA 
                 200 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTATCTGAAAAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 4 
                 19 
                 + 
                 28 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGAGAAGAACAAGCTCAGACT 
                 201 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAAAGAGTAAGAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 4 
                 19 
                 + 
                 63 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCACAGCAGGTTAATTTTCTATTT 
                 202 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGGGAAAATGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 2 
                 18 
                 + 
                 −16 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGCATATTAAGCAAGATGAACA 
                 203 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTCGGGAAGCAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 2 
                 18 
                 + 
                 19 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTAGATGTATCTGCAGAGTTAG 
                 204 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCTTCCACAGCACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 2 
                 18 
                 + 
                 54 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACTTTAAGGACCTTTGGACAAA 
                 205 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTAAAAGAATGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 2 
                 18 
                 + 
                 89 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGAAAAGATTTTACCTTGTACT 
                 206 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTCTATCATGAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGAGCCGGGGCGCGGGCGCGCT 
                 207 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAGCGCCGGACACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTTAACCAGGGTCAGCGAGATG 
                 208 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGTAGGTCGTTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 66 
                 + 
                 27 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGCTCGAGTCGGTGCCTCCGCC 
                 209 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCGCCTTCTCCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 109 
                 − 
                 23 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCGGAGCCTCTGGCACCGGCGG 
                 210 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGCCGGCCGCGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGAGACTGGGGATCCTGGCAGCC 
                 211 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCGAGGCGCGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAGAGACGTTCGTGCCGCTTCT 
                 212 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCCCGGCTCCTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACCGGCAGGATGCGCTGTGGAT 
                 213 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGCACGAGCAGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACAGGGCTGGGGGCTCCGCGCCC 
                 214 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGGTGCCCGCGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCCGGCTCCGGCCAGTCCGGCC 
                 215 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGCCCAGTCTCCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACGGCCCAGAGGGAGAGGCGGC 
                 216 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCCGGGAGCGGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCTCCGGGACCCCCGCTCTCCG 
                 217 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGGACTGAGCCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGGAGGTGGGGGCGCCCCCA 
                 218 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCTTGGGGTCGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGCGCCCCCTGCTCAGCAGCCC 
                 219 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGCTGGGGCGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGATGCCGCCGCCCGCCCGGCCT 
                 220 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCGGGCTCCGGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 490 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGCTCATCCTCTCCGCACCCTG 
                 221 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCACCGGCAGCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 525 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGCCGGCGGAGGAGGCGCCA 
                 222 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTTGAGCCTCCGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 560 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAGCCTTGCAAGACCGTGACCA 
                 223 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGAGTGGAGCCAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 595 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGGCGGCTACCCGCGCCCTTGC 
                 224 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCCGCCGGCTTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 630 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCATGGCCCGAAAGCGAGGGCAA 
                 225 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCCAGGGTCAAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 665 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGAAGCTCCAGTCCCGGCGCTG 
                 226 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTTTGACCCCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 700 
                 + 
                 25 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCTGCCGCCGCCACCGCCGCC 
                 227 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCGCCGGGGGAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 735 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGACCCCACCAGAGGTCGAAGC 
                 228 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTAGAGCCCCCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 770 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCTGGGGCTGGAGCCCGAGGG 
                 229 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGTTGTCCCCTCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 805 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCACTGTTGTCCAAGGTCTTACT 
                 230 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTGCCTTTCCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 840 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGCATCCGGGACCGCCTGCCGG 
                 231 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTCCTCCTCCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 875 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGTGGCTGGACTCGGAGTTGGT 
                 232 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGAGGGTTAGCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 910 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGTCACCGCTGCTTCCGCGCAG 
                 233 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCCCCGGGCCTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 945 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCGGAGCTGGAGGCTCCAGAGT 
                 234 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATTGGAGGTGCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 980 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGAAACGGGGCCGGGAGGGG 
                 235 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCCGAGCATCCAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 1015 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCGCTGATAAACTTGAGCATCT 
                 236 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCGGTCACGAGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 1050 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCTTCACCAAGAGCACAGGAGG 
                 237 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCTCCTGGCTCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 1085 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGAAGACAGGCTGGGGGGTCC 
                 238 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGAAGGGGCCCGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 1120 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGCGGGTCCAGGGAGCTGCTG 
                 239 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCGCCGAGCTCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 19 
                 12 
                 − 
                 1155 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCAAGCCCTGACTCAACTCACT 
                 240 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGGGAAGCGCGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 1 
                 19 
                 + 
                 −56 
                 + 
                 2 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTCCTCTGGCCGCCCCTCCCTCC 
                 241 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCGCGGGGACCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 1 
                 19 
                 + 
                 −25 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCTGGCCATGTCCTCCTGCCGC 
                 242 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGCCAGGGGTCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 1 
                 19 
                 + 
                 9 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACGCCGTGCAGGTAGGCGCACC 
                 243 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCGTCTGGAGTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 1 
                 19 
                 + 
                 41 
                 − 
                 32 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGGTCCGCCGGCGCCGTCCGGT 
                 244 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGCCCCGGGACTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 5 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATATAAGAAGCTGTATAATGCT 
                 245 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGGAGGATGCCACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 5 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATAAAGGCTTTCTTTAGCCATC 
                 246 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACATCAAATTGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 5 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCAACTGCCAATGGACTGTTTT 
                 247 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAATGCCATCTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 5 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATATATGGTGTAGCTGTGGAAAT 
                 248 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCGTCTGGAATAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 5 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAATGGAGAAACATCTACAAAAT 
                 249 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCTTTGGGTTAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 5 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCACAAAGAATTTTTATTCTGA 
                 250 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGCACTATTTAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 5 
                 3 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCTACGTGAATGTAAATATTCG 
                 251 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGACATTGATAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 5 
                 3 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTATAAAATAATAAGCATCAGCA 
                 252 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTGACTTTACCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 12 
                 12 
                 − 
                 −8 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCTACGGATCCAGCAAGGTTAG 
                 253 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCGGACAGAGTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 12 
                 12 
                 − 
                 27 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTCCGTAGAGGGTTGTTGATGT 
                 254 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACACGGAACGGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 12 
                 12 
                 − 
                 62 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCACCTCGCTATTCAGACCTGCA 
                 255 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATCAGTCAGACACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 12 
                 12 
                 − 
                 97 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCTTACCTTGTTGATTTTGTTGG 
                 256 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTTGGGGAGCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 2 
                 4 
                 + 
                 −46 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAATGCTGTTTCTGTTGACTTTTG 
                 257 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTTTTCTAGTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 2 
                 4 
                 + 
                 −11 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAACGCCGGATGGGAAGTCCCCA 
                 258 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGCTCTGGGAAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 2 
                 4 
                 + 
                 24 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGTCTTAGGCTGTCTTCTCACA 
                 259 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTACGGAGCCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 2 
                 4 
                 + 
                 59 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACAAGACACCCAAACAAGGAAC 
                 260 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAGAGAGGACTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 14 
                 2 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCCACCATCTGCTCCCCTGAACT 
                 261 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGATTTCAAATACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 14 
                 2 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTACTCCATTCCAAGTTCACAGA 
                 262 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTCTCGTTGACACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 14 
                 2 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCTCAGAATACAGGTGGCCGCC 
                 263 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGACATTTCCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 14 
                 2 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCACCAGCTCCACATTTCTTGCA 
                 264 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACCACATTATACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 14 
                 2 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCAGCAAGTGCCGACCCTGTGG 
                 265 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGTGGGGTCCAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 14 
                 2 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGTGGTCTTCAAGCCATTCTGCT 
                 266 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGGGTGTAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 14 
                 2 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGTCTCCATCACTGACCTCCTA 
                 267 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTCATACCAATACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 14 
                 2 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACACTCCATTCACAGCCCAGAT 
                 268 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCAAAGGTGTAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 14 
                 2 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAATATAACCCTAACCCAGACC 
                 269 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATCAGTTTCTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 14 
                 2 
                 − 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCAATTCCTACCTGCTTGGTTGGT 
                 270 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTCACAGTGAACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 11 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGAATTTGGAGAGGTGTGCAGT 
                 271 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTCGCTTAAAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 11 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTAATGGCCACTGAAATCTCTTTT 
                 272 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTGAAGGAAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 11 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACCCTGAAAGTTGGCTACACAG 
                 273 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAGCAGAGGAACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 11 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGTCCCATAATGCTTGCTTCTCC 
                 274 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGGAAGTCTCACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 11 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTGACCACCCCAATATCATTCG 
                 275 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTGGAAGGAGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 11 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGTCTTATGACTACTTTACTTAC 
                 276 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTTGGTAACAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 23 
                 13 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACATTCAAACGTGTTTTGATCAA 
                 277 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAAGAGGAGTAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 23 
                 13 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAAGACCGAGTTATAGAATACT 
                 278 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATAATAGAATCAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 23 
                 13 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCAGAGACTGAAAACAAATATT 
                 279 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGCAGTATGCTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 23 
                 13 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAATCAAAGGATACTTTTGACC 
                 280 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACCCTGGTGGAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 23 
                 13 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAAATCTAATGTAATGGGTCCA 
                 281 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAAAACATTAAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 23 
                 13 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGCTAGAGCAAAAACAAAAAA 
                 282 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTAGATTATTTATACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 23 
                 13 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTACCTTGTCACCAATACCTCAC 
                 283 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTCCTCGAAGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 23 
                 13 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAATCCGTAAGGGTGAACTAGGA 
                 284 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACTTGTAAGGGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 23 
                 13 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGAGGGAACATCTATATTTCA 
                 285 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCCTGAAGAGTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 23 
                 13 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTGGTGTTGGCAGACCTTCTGA 
                 286 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATTTTATATGGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 23 
                 13 
                 + 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAAATGACTCCAAGATCAAGGT 
                 287 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGTGTTTTCTCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGGAAGAAGTCAGTGGCTACGA 
                 288 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAAAACCTGAAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGAAGACATTGCACACCTGGTAG 
                 289 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGCGGATGGTGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCCCAACCAGAACAATTGGCTG 
                 290 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCACCACCTTCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTGTGTAGATGCGATGGGCCCC 
                 291 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGCCGGTTGATACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATGCGCTTCACTGTGAGAGACT 
                 292 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAGCAGCCTCCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTGAAGGTCTCCTTGCAGGATC 
                 293 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGGGACATTAGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGTATTACTATGAGACTGACTCT 
                 294 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCATTGCCACACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTAGGGGGCCTCAGACCAGAA 
                 295 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCTGACTTCTTGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCAAAGTAGACACCATTGCTGCA 
                 296 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATGAGAGCTTCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCTTCATCAGCCTTCCCCCAAA 
                 297 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCCACCTGGGAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAACACAGAAGTCAGGAGCTTTG 
                 298 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCCTCTTACTCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCATAATCCTGAAAAGCGAGGT 
                 299 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAACCATTCCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCTGTATGTCTCTTCTTTCTGTC 
                 300 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGTGTCTTCTTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGCAAAATTTTGCACAATGCTG 
                 301 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGACACTTTTTGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 490 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTTTCCAGAGACTATGACAGGG 
                 302 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAGAGAGCACAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 525 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGGGGATGCATGTGCCCCGAGC 
                 303 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATCACCAGAGAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 560 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCAGAGGAAGTGGACGTGCCCA 
                 304 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAAACTCTACTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 595 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCAATAGGCACCATCCATTCCC 
                 305 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATCCCCGTTGCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 630 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGATGCACCTGCAAGCCTGGCTA 
                 306 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAGCCTGAGAAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 3 
                 3 
                 + 
                 665 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGAGGCTCCAAAGCTTACCCTTG 
                 307 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATGCCACGCTGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 22 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGACATGAAACAGCTGGCTGAA 
                 308 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATGTGAAGCTGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 22 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTGGATCAGGAATTTCTAGTAA 
                 309 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTATACAGCTGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 22 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAAAACTGGGCTACTCTGGCGC 
                 310 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAAATTAGGTCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 22 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGACTCAGCCGGAAGGCATTAT 
                 311 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAAGTATCCCCAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 22 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTCCTTCCAAAACACTTATGGA 
                 312 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAACTATGAGGTACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 13 
                 18 
                 + 
                 −26 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGCATGCTCTTTCCCTTTACCTA 
                 313 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGATGTATCCTACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 13 
                 18 
                 + 
                 9 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCTCCCGGATCTATACTCCACTG 
                 314 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATATTTTCAAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 13 
                 18 
                 + 
                 44 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACCTTTCTCAGTATAAAATGGA 
                 315 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTTACTGTAATACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 13 
                 18 
                 + 
                 79 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTTTGGTTTTACTTTTTAACTTA 
                 316 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTTTGTATCTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 7 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTCGCAAACCTGGGTATACTTC 
                 317 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGTGACAAAGAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 7 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTCATTCGTGCTTCCAGTGTTTC 
                 318 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAATACTTTTTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 7 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGGCGTGTATAAGGGGCTATAA 
                 319 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCTGGACTCTTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 7 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTCTGCTTGCAAATAGGCAAGG 
                 320 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAGGGTGCACCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 7 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGGAGGGGACCGGCAGCTGGG 
                 321 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGTAAGCATCATACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 10 
                 4 
                 + 
                 −24 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACACTTCAATGTGATTGTTTGCA 
                 322 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATGACATCCAGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 10 
                 4 
                 + 
                 11 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTCCACCATTTTCTTCCTCTTCA 
                 323 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAAAATCGAATACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 10 
                 4 
                 + 
                 46 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGGAAGGATTTGGAGATTTTT 
                 324 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCCCACAGATGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 10 
                 4 
                 + 
                 81 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAATAATAATAATAAATCACTTA 
                 325 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTGTCTATGAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 2 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGCCTCCACGACCATCATCAGG 
                 326 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAACTGTGGGGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 2 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTCTACTAGGATTCTTGGGGGC 
                 327 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCAAGTGGATGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 2 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTTACTACCAAATGGAATGATA 
                 328 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGACTTTAGAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 2 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCTTTATGGTTATTAATGTAGCC 
                 329 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCACGGAGGCAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 2 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAACTATTTAAAGAAGCAAGAA 
                 330 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATACCCCCTCCACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 2 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAAATGTAAGAAGATTCATCTT 
                 331 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAGAAGTTGATACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 2 
                 3 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTAAGTGTTACTCAAGAAGCAGA 
                 332 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGGGAAGAATTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 2 
                 3 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCGAAGGTCACAAAGTCGTCTT 
                 333 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTTCATCAAAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 2 
                 3 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTTTCAACCCTTTTTAAAAGTAA 
                 334 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGAACCAGTAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 2 
                 3 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTCTCGATTGAGGATCTTTTCT 
                 335 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCACGGTTGCCACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 2 
                 3 
                 + 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGTATGATACAATATCCTATTCT 
                 336 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAATGCAAATACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 10 
                 2 
                 − 
                 −44 
                 + 
                 13 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGTTTGAGGAAAATAATTCTCT 
                 337 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTTTAAAAAAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 10 
                 2 
                 − 
                 −1 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCTTCTTGTTTGGCTTTACTGTA 
                 338 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTACTCCGTCACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 10 
                 2 
                 − 
                 30 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCGGATGAAGAGAAACATTTGA 
                 339 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCAAGGTACAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 10 
                 2 
                 − 
                 65 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATGCTCTAAAAATAGAATTTTTT 
                 340 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATCCAATTTTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 23 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCTCTGGGGGTACAGTCAGAGA 
                 341 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTGGTGGAGGCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 23 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTCAATTGCTTCGGTGTAGCCCA 
                 342 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTGTCTCAGGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 23 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGATCCAGGCAGCCTCCAGCCCA 
                 343 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGAAGACCACCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 23 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGGCAGGCGAGAGAGGCAGCG 
                 344 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTGGGCCTGAGAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 23 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACAAGGCAGCAAATAGGTAAA 
                 345 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAAAGACAAAAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 20 
                 4 
                 + 
                 −8 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTCGCAGGAGCAGATCCCCTGG 
                 346 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGAGAACTTTGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 20 
                 4 
                 + 
                 27 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTTCCCAAGAGTCATCCAGGT 
                 347 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATAGAGAGGCTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 20 
                 4 
                 + 
                 62 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGGAGAGGATGAAGGAGTTG 
                 348 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCCTGGAACCACACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 20 
                 4 
                 + 
                 97 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACTCACCTGCCAGCTGGTGGCC 
                 349 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATATCTAGAGGCACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 4 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCAAATAATAGTGGTGATCTGG 
                 350 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTAATAGTTTCTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 4 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTTCAGAGTATACTTCTGCTTG 
                 351 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCATTATTTGGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 4 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAACCATGACTGTGTACCAGAAC 
                 352 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGTAATTGCTGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 4 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGCAACATACTTCGAGTTTTTTT 
                 353 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTGATTGCTTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 4 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCTCTGAACAACTAAAACTCTG 
                 354 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTTTTAGAATAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 4 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACATCCACACACTTTTAAAATA 
                 355 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACTTGCCCTGAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 4 
                 3 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGAATACTTCCTAGAAAAATAT 
                 356 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTCTGAGTCAGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 4 
                 3 
                 + 
                 241 
                 − 
                 9 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAATATTTTGAAACTTGTTACTCA 
                 357 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTTATACTGAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 4 
                 X 
                 − 
                 −22 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATGTCTCTCCTTCTTTTGCAGCT 
                 358 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATCGCATTCAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 4 
                 X 
                 − 
                 13 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATTTTGAAGAATTGTAACAGTG 
                 359 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGAGACTGACAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 4 
                 X 
                 − 
                 48 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAGTGAGGGCTATGAAGTGGAG 
                 360 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTCGAGGAAGAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 4 
                 X 
                 − 
                 83 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAAAAACAAAAAGACATTATAC 
                 361 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTGAGCTCTGTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 21 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCCCATTCCCAGGGGATGATGA 
                 362 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAGGAGGTCTTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 21 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGGGTAGCGAACCTCGTCGTTG 
                 363 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACGATGCTGTCGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 21 
                 19 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTTCCTGTCGGCCGAAGCCATC 
                 364 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCATCATGAGAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 21 
                 19 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCCAGGCCCGCCCCACGTCGGG 
                 365 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTCCTCACCCTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 21 
                 19 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGGGCAGTGGGGCCCAGGAGG 
                 366 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGACAGATCCTGAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 21 
                 19 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCCTCCGAAGCAGCTTGGAGGA 
                 367 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGAGCACTGTGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 21 
                 19 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCAGAGCGGAGGCTGGGATCTA 
                 368 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCGAGAGAGATGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 21 
                 19 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACCCTGAAGAAGGGCTGTTTCT 
                 369 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCACATCTTCTGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 20 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATATGATGCAGCCATTGACCTGT 
                 370 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTACACGTTCATACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 20 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCCAAAATGAAGGTAGCTACAC 
                 371 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTATCCAGCACACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 20 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTGGAGATCGTCACAATAGTAA 
                 372 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATCATGGTGAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 20 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTAAACAGAGAAAACCATTACT 
                 373 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTCCATCGTCTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 20 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGTTTTGGTGTTCTTAATTTATT 
                 374 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAGACATTTTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 20 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGAAATTATGTTATAGTTTGAT 
                 375 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATATGCAGATACACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 20 
                 3 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTTTGAAAGCTGTTTCATATAG 
                 376 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTTTGGACACACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 20 
                 3 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTATAACCAAATTTTTTCTTCTTG 
                 377 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGATCCAAAAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 20 
                 3 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACGAGAACGTGTGCCATTTGTTT 
                 378 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGACACAGGATTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 20 
                 3 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCATTCTTGGGCTCCTTTACTAAT 
                 379 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACTATTAAGAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 20 
                 3 
                 + 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACAAAGACAAGAGAATTTGAGA 
                 380 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTGAGCTCGAGCACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 4 
                 18 
                 + 
                 −22 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTATTTATTTTTTGACCTTTAGAG 
                 381 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGCACAAAGAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 4 
                 18 
                 + 
                 13 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCAGCTGTTGATTTTTGGTGAAG 
                 382 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATTCTTCTAGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 4 
                 18 
                 + 
                 48 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAACAGCAGAAAGTCCTTCATG 
                 383 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAACCATTAAAGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 4 
                 18 
                 + 
                 83 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGACCTAAGTGCCAGACTCACC 
                 384 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATCTTCTAAAAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 8 
                 15 
                 − 
                 −18 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTTCTGGTTCCTCACAGGTATCC 
                 385 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATAGCAGTTGGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 8 
                 15 
                 − 
                 17 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAACCACCAACAGGACACAGGC 
                 386 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAGCAGCAAGTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 8 
                 15 
                 − 
                 52 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTTCGTCATGATCAACAAATAT 
                 387 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTCGACGGTCCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 8 
                 15 
                 − 
                 87 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATGAAACTCCCACCTTACCCTT 
                 388 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATTCCAAATTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 6 
                 2 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAAATGATGGCAGATTTACAGT 
                 389 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATTCAGCTGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 6 
                 2 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTTCATCCCAGACCCAATGCCA 
                 390 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGAAGCATGCCCACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 6 
                 2 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTATCTGATATGAGCTATGTGC 
                 391 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCGTGATCTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 6 
                 2 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCAAGTTGCTGTTCACCAGGAT 
                 392 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTCCGTGCGGCACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 6 
                 2 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGCAAAGTGTCTGATTTTGGCA 
                 393 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTCCCGAGTGCACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 6 
                 2 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTGGTGGTGTAAGCTGCTTCCG 
                 394 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATCATCCTCAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 6 
                 2 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTAAGAAAGATCGGTGACATCTG 
                 395 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCTTTCACTCTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 18 
                 15 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGGATGTCTCTCTTTGCCCAGCC 
                 396 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGTGTAGTTTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 18 
                 15 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGCCAGACGCTTCCCAGCAAG 
                 397 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAATCCGCCAGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 18 
                 15 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTATGTGGGCTCCGTGCTGGCT 
                 398 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCCCTGCAAATACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 18 
                 15 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCCGGCAATTGATCTCAGTCTT 
                 399 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTGCAGACACAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 18 
                 15 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCGGACGATGGGAACCTCTTCC 
                 400 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCTCCTGGAAGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 18 
                 15 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTGGCGTTCCCATTGCTGTTCCC 
                 401 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAATCCTGCCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 18 
                 15 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCAACATCACGGACATCTCAAG 
                 402 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAATATCACTTCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 18 
                 15 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGGCAGGCTGGGGAGCGGCCG 
                 403 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTGACTTACATGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 7 
                 3 
                 + 
                 −17 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTAAAATTTTACATAGGTGGAA 
                 404 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAATGGCTGAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 7 
                 3 
                 + 
                 18 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCACGAGGAAGATCAGGAAT 
                 405 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTATATATCATAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 7 
                 3 
                 + 
                 53 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCGACTTTGCCTTTCCATTTGCT 
                 406 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGTTAAAGGCACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 7 
                 3 
                 + 
                 88 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTCTGAAATACTTTACCTCTTTA 
                 407 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCACCCTTTCGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 15 
                 15 
                 − 
                 −36 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTTTTAAAATTTCCCTTTATTTG 
                 408 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAATCTTGCAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 15 
                 15 
                 − 
                 −1 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGAGAGTGTGGTGAGCCGGTTAC 
                 409 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGACAGGTTTCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 15 
                 15 
                 − 
                 34 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCAGCTCTTCCAGACGCTGAG 
                 410 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTTCGGGAATTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 15 
                 15 
                 − 
                 69 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCAGTACCTGGACAGTCTTCAA 
                 411 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACCAAACTTACACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 6 
                 16 
                 − 
                 −27 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATTTTTGGCTGCTTTGTTTTATT 
                 412 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGGTTCCAGTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 6 
                 16 
                 − 
                 8 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATTATACACATCAGGCACTGGA 
                 413 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTATCTGTAATACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 6 
                 16 
                 − 
                 43 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCGTGTGTGTAGCTTTGGGAAAT 
                 414 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGGAAATCAGAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 6 
                 16 
                 − 
                 78 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACAAATCACTCCTTGGGAATTAC 
                 415 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATACCTGATCTCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 16 
                 3 
                 + 
                 −16 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCTCTTTCCTCCTAGAGACCTCC 
                 416 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAGAATAGGCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 16 
                 3 
                 + 
                 19 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCAGGATCTTCTTCTGATGGCCT 
                 417 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCAAGGTGATACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 16 
                 3 
                 + 
                 54 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCATTCATTCTATGAGGGTCC 
                 418 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGATAAGTCAGTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 16 
                 3 
                 + 
                 89 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGAAACAAGAGTTCTCATGCCA 
                 419 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGCCGTTGGTGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 11 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTGCCATTGTCTTCAAAACTCCA 
                 420 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGTATAAAGAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 11 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGACAAACACAGAGGCTGGTTTT 
                 421 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTAATATTAATAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 11 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCTTCGGAGGAAATCTGACTTG 
                 422 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAACTAGTGAAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 11 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTTTGATTTCAGGATAGTAGAG 
                 423 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAAGGTTTTGGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 23 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCGCAGACCTCTGAAGAGAGTG 
                 424 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCATTGAGACGGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 23 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCCTCTCTCTTGATGAAGGTGG 
                 425 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACTGCTGGAACACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 23 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGACCATTGAAGACATCGACAT 
                 426 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATGGATGACATACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 23 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCTGTCTTCCACCAGGTCTGAA 
                 427 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGTCTATGCCGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 23 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCTGTAACTGGCGGATTCGAGG 
                 428 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTTCCTTCCACACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 20 
                 13 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTATCGGCTAGCCTATCTCCGG 
                 429 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTAAATACACTTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 20 
                 13 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTAATTCTGGGTGCTCAGACAG 
                 430 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGGCGTTCACAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 20 
                 13 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACATATCATCTGGACCCTTTTCCA 
                 431 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCACACCCTGCACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 20 
                 13 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAATGCCTGTCTCTCATGAGTTC 
                 432 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATACTCATTCTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 20 
                 13 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACCAAGTAAGAAAATCAAGCA 
                 433 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTCACCTTCTCTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 14 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAACCATGGACACTGAATCTAAA 
                 434 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGGACCCTGAAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 14 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTACAGTGTTTTTGTCATCACTT 
                 435 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGTCACAACCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 14 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCTTTGGGAAAGTTATTGAAA 
                 436 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCACAGAGCAAGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 14 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCATTCCCAACGGTGGCCTCGC 
                 437 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGGCTCCTGATACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 14 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGGTCACTCTAACGTATGCAAC 
                 438 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGAACAAAAGAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 14 
                 4 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTGTGCTCACTTACCCTGAACTC 
                 439 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGCACTCTCTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 12 
                 16 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTAAAGGAGAAATTAGCATTCTT 
                 440 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAAAGGGAATAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 12 
                 16 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTCACTTACCTGAAGGCGGGCT 
                 441 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTGTCTTGCTGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 12 
                 16 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGTATTCTCAAATTAAGGTGTTAT 
                 442 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTACAAACAAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 12 
                 16 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTAAAGTTTTATAGAGTCAAGA 
                 443 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTGTTTTTAAAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 12 
                 16 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAAACGTATTTCTGGGGCTGTT 
                 444 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTGTCTCCTCTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 12 
                 16 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGAATGCTTAATCTTTTCAGCTCT 
                 445 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGGGCACGCTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 12 
                 16 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTAAGAAAACAGTAGAAGAAC 
                 446 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGATTGTTTGTCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 12 
                 16 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGAGTGTTTTAGCTGCGGTGAG 
                 447 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGATCCTGCTGAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 12 
                 16 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTAAATCTAGACCATTCACTTAT 
                 448 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCTGCTTTATTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 20 
                 1 
                 + 
                 −11 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTTTCTGCAGATATACTCCATTT 
                 449 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCAACGGTCCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 20 
                 1 
                 + 
                 24 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGATCCGGGTTAGGATTTCCTCT 
                 450 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTGTGTCACTGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 20 
                 1 
                 + 
                 59 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGTGGGAAGTTTACCCTCAGT 
                 451 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGGGAAATTGGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 20 
                 1 
                 + 
                 94 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTACAGACTCACCTTGGCTGTCTCT 
                 452 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAACTGTGTTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 17 
                 12 
                 − 
                 −40 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCAGGAGCCTCCCCTCTTACTG 
                 453 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCTTCTCCCGTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 17 
                 12 
                 − 
                 −5 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGTCCATTCCTGGCTATTGATC 
                 454 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAGCCTCTGTAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 17 
                 12 
                 − 
                 30 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAGCCGCTCCATTCCTGAACTG 
                 455 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGCCTGGTAGGTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 17 
                 12 
                 − 
                 65 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGTCAGCCTTCCCTATAGGCAA 
                 456 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGGACTGGGTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 13 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAACACGATGCCCAGTTTACTGT 
                 457 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATTCAGCTAGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 13 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTTCATGCCAGATGCTATCCCTC 
                 458 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAGCATCCCCACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 13 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCTGTCAGACATGGGCTATGTT 
                 459 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACCGAGACCTCACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 13 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCAAGTTACTGTTGATCAAGAT 
                 460 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTCCGAGCAGCACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 13 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGTAAGGTTTCTGATTTCGGACT 
                 461 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCGCGTGTCCACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 13 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTTGTTGTATAAGCAGCTTCTGG 
                 462 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCATCCTCCAACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 13 
                 3 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGAGTAACTTAGATTTTCTCCTT 
                 463 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTTATCATTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 6 
                 3 
                 + 
                 −8 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTTACAGCTCCATCACCTGTCCT 
                 464 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACGATTAAGAACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 6 
                 3 
                 + 
                 27 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGACAAAGAGATGCTATTTCTGG 
                 465 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGTCCGATCTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 6 
                 3 
                 + 
                 62 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCAAGAACCTGAACATCCTAA 
                 466 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGGATCATATTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 6 
                 3 
                 + 
                 97 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCCCACCTTTTCATAGTATTTGA 
                 467 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTCGTAGTCCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 7 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAGGCAAAGGCATCACAATGCT 
                 468 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAAGAAATCAAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 7 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGTCAAAGTGTACACCAATTTG 
                 469 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGGATGGGACTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 7 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCCCGAGGCCACGGTGAAAGAC 
                 470 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTGGAGATTACACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 7 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGACCTCCCTGGTAGCCTGGCG 
                 471 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCAGCACATTCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 7 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGAAATGAAGAAAGTCACTATTT 
                 472 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGTCCATGGTAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 7 
                 4 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCATGGACAACTGACATTTTA 
                 473 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAAGCGGAATGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 7 
                 4 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCGGGATCCATATGTGGTAATC 
                 474 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTATTTAATGGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 7 
                 4 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCAATGAAACCTTTCTCTGTACA 
                 475 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGAAGAGTTTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 7 
                 4 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCAAACCCACCTTCAGCCAGTT 
                 476 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAAGCTGTCAAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 7 
                 4 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCACCTCTACAACAAAATGTTTG 
                 477 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTTCATGCAGGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 7 
                 4 
                 + 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGCCTACCCACCTCCCAGGATA 
                 478 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCTGGCTGAAAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 7 
                 4 
                 + 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCTCAGTGAGATTTTCAATCAG 
                 479 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTCAGATTGTTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 7 
                 4 
                 + 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACCACTGATGTGGAAAAGATTC 
                 480 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGAAATAAGGTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 14 
                 10 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCCGCTCCTCCTCATCGTGGAG 
                 481 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACGCCAAATACACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 14 
                 10 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGCGGCTCTCGCGGAGGAAGCC 
                 482 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGCAGGGAGCCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 14 
                 10 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTGGGGCCTGGCTACCTGGGCA 
                 483 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGAGGCAGCCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 14 
                 10 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGCTCATCCGGGTGGTCCAGGG 
                 484 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCTGGAGTTGCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 14 
                 10 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCCTCACCATGGGCGACCTCAT 
                 485 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCATTTGCCTGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 14 
                 10 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCGGCCAGATACTGCATCCCC 
                 486 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTGAGATCTGCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 14 
                 10 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAAGGTGCGTGCATATGGCTCT 
                 487 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCACCCAGCCAGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 18 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCTGAATGCCATTCATCTAGCC 
                 488 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGATGAGCAATACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 18 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGCGGCCACCAGCAGCAGCAA 
                 489 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACATGGCAGGCTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 18 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCTGACGTCAATGCTCAGGAGC 
                 490 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAAGTCCGGGCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 18 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTGTCGTGCTCCACAGCCAGGT 
                 491 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAGTGCTGTGCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 18 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCTCATTGGCAGGCTGCCTGCT 
                 492 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTGGAGGTGAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 15 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTAATTAAAGCTGTAGATGAGGG 
                 493 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTATCGACTGCCACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 15 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGATACAAGGCAGCTGGGCAG 
                 494 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCATGGGGGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 15 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGATGCTGGACTGCTGGCAGAAA 
                 495 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACAGGAACAACACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 15 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCAGAATACTAACAATCTGCTC 
                 496 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAACTTGGGTCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 15 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAGCTTATCCGGAATCCCGGCA 
                 497 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCTGAAGATCAACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 15 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAATTGAATGTGTCACCTTGCGG 
                 498 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGCACTGGTGAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 4 
                 19 
                 + 
                 −2 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGACCGGAAGCTGCTGCTGACA 
                 499 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCCAGCAGATGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 4 
                 19 
                 + 
                 33 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGATGATGTCAATCTTGGTCTT 
                 500 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTGTCCTGCAAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 4 
                 19 
                 + 
                 68 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATGCAACTCCGCCGGGCGCTGC 
                 501 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGCCGGCCAGCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 4 
                 19 
                 + 
                 103 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCTTGGGTGTCATCCGGGGCTG 
                 502 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTGGTTCTCCAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 17 
                 2 
                 − 
                 −36 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGGAAATTCATCTATTTTTCTTT 
                 503 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTTTTTTGCAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 17 
                 2 
                 − 
                 −1 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCCCTGAACAGATCTGGAATC 
                 504 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAATAAGGTAACACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 17 
                 2 
                 − 
                 34 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTTGGGTGGATAGCAAGCCCTC 
                 505 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGAAGGAGGGGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 17 
                 2 
                 − 
                 69 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTACCCTTTGGATCAGAGAGCA 
                 506 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTCAGGACTTAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 21 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTTCAGGAGATGTGTTACAAGG 
                 507 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTATCTAGCTAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 21 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAAAGATTTATGAAGAGATTGG 
                 508 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATGCTGTCGAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 21 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCAATGATGCTTGGCTCTGGAAT 
                 509 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCAGAACTACAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 21 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGTCTTTCGAATGTATGCAATG 
                 510 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCATCAAAAGATACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 21 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGCCTTAGATAAAACTGAGCAA 
                 511 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGGCTTTGGAGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 21 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCATGATGTGCATCATTCATTTGT 
                 512 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCATGAAATAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 21 
                 3 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCTGGACAACAAAAATGGATT 
                 513 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGATCTTCCACAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 21 
                 3 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTATCTTTTCAGTTCAATGCATG 
                 514 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGTTTAATTGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 3 
                 X 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCAAAGGCACAGAGGAAACCT 
                 515 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTGGCTGATTGGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 3 
                 X 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGGCACAGGAAGGGGCTTCATG 
                 516 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGCCTTTTTTCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 3 
                 X 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACCAGTGGACAAAGATGGGTAA 
                 517 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGAGTTCACAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 3 
                 X 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGGCAGAGTATGGCATAGGAAG 
                 518 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTCCAATTAAAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 3 
                 X 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTTTCTTCACTACCTATTTGATG 
                 519 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTCCCCTGCCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 3 
                 X 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCACTGGTTGCAGGCCATGGCCC 
                 520 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTTGCCTGCAGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 3 
                 X 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGATTGCAGCCTTCCAAAGAAGA 
                 521 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAGCAGAAAGGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 3 
                 X 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCCATTACCTTATGGCTTGTTT 
                 522 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCACCAACTGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTTCAGATTCTACTTCAAAGAC 
                 523 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCTCCTCAAGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAATACAGGAGATGACACTCGAG 
                 524 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGGTAATTCTTACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGCTACCTCTAGTATCAAAAG 
                 525 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGTTTAGATTTACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGGCTGTAAAAGAGAAGGGGA 
                 526 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAACTTGTATTCACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAAAAAAAAACATCTGAAAAC 
                 527 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTCCCTTTTAGCACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATCTAGTTTTTTCTAATCTAGAT 
                 528 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATACAAGTGTTACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAATCTGAAGATAGTGCCCTTT 
                 529 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCACACATCACAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGATAATGATCTTGTTCACTTC 
                 530 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGACCCAAGACACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCATCTAATAAACAGATACTTAT 
                 531 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAATAAAAATATACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTCAGTCCTATTCTGTTCACCTA 
                 532 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGATTCACTTACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACGGTAAAGATTCTAACACTGAT 
                 533 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAACATTTGGAGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTTTGGATGTTCGGCCTCCCAAT 
                 534 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATTTCAGGGGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAGAAAACTGAGGAAGAAAGT 
                 535 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAACATGAAGTAAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCATTTTCTTTATCAAAAGAAG 
                 536 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTGGGGGCAGCACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 490 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCCCTTTTCCAATGGATAATCAG 
                 537 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTTCCATGAAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 525 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACAGATCCAGAGGTTTATCCATC 
                 538 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACACAGTCTCCAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 560 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGATCGATTTTCAGCTATTCAGC 
                 539 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCAAGAGAAAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 595 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTAAATTTGTTTTTAGAAGTCTCA 
                 540 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTCCTTGGCTACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 630 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAAGTGACTCTTTATGAGGCTT 
                 541 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAAGACCATTCACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 665 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCTGAGGCCTTACGGCTTGAGG 
                 542 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAGCCCTTTGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 700 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCAACTGCACGTTGCCCAAAGA 
                 543 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCCCCAGGGGAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 735 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGGCTGAAGGATGATGCATTCC 
                 544 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTGAACAGGGCACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 770 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAATAAATGCTCTCCAGACAAT 
                 545 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAACCATCATTAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 805 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAATTTTAAAGACAGCATTTTC 
                 546 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCTTTTATTTGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 840 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTACGTCCACGTGAAAGTTTGG 
                 547 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGACTGAGAATGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 875 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAACATTTAACACAAACCTTTA 
                 548 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTCATCTAAAAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 910 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGATTTTGATTAAAATGATTGC 
                 549 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGTGATTTCATACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 945 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCACTCTAAAACAGAAATAAT 
                 550 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTTAGCTCTAAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 980 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTCTCATGAGCCAATAAAAATA 
                 551 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAACCAGGTCAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 1015 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAAGAACTGATGCAAGTTCACA 
                 552 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCTCCATGGTCACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 1050 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTAAATCCATGTAGAACTGGTA 
                 553 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAATAAAGTCTCACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 12 
                 18 
                 + 
                 1085 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTGTTTATGGTGTACACACCTTG 
                 554 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTGTTTTGTAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 5 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGTCCCATCAGGTCCCCGCAAT 
                 555 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTATCTCCATCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 5 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGTGCCACTCCAGAATGATGGA 
                 556 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGTCTCATTGACACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 5 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCAAGGGAGACAGGTGGGCGG 
                 557 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATGATGTGACCTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 5 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGGTCTGCCCGGCACTTTTTGC 
                 558 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGATGATGTTGTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 5 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGAGCTGCTCCCGCTGTGACGA 
                 559 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAATGTGGAGTTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 5 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCGGCACTCCGTCAGGCCCAGC 
                 560 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCCTGGGCACAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 5 
                 3 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCCATCAGCAGCCTGTGGGCC 
                 561 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACACCCCCTACACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 5 
                 3 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGAGACTCCATTGATGGCCTG 
                 562 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATGTCAAAGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 5 
                 3 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAGAGTCCCTTCCCCCCACAGC 
                 563 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACGTCTCTGTCAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 5 
                 3 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCTCCAGACTTACCGGCTTGGT 
                 564 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGTGGTGATGTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 9 
                 1 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTTTGGCCTGAGCAAAGAGGCC 
                 565 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTGACCACGAGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 9 
                 1 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTACTCCACTGTCCCGCAGAAAGA 
                 566 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATAGGCCTTCTTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 9 
                 1 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATGGCCCCTGAGGTCGTCAACC 
                 567 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCAGGGCCACTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 9 
                 1 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAACACCCCATAGGACCACCAGT 
                 568 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGCACTATGGGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 9 
                 1 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGGTGAGTGCCCAGACAGGGGT 
                 569 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAGGATCCAGCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_001006665 
                 1 
                 1 
                 + 
                 −2 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGATGGAGCAGGATCCCAAGCCG 
                 570 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCCGTCTGCGGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_001006665 
                 1 
                 1 
                 + 
                 33 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCTTCCTGGGAAGCCAGGGGAT 
                 571 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGGGCCCAGAGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_001006665 
                 1 
                 1 
                 + 
                 68 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGGCCCAGGATCAGCCAGACCT 
                 572 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTGCCTGTCCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_001006665 
                 1 
                 1 
                 + 
                 103 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACCGAGTCCCGCTGGGGGCCAG 
                 573 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCCAGGGCCAGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 16 
                 X 
                 − 
                 −28 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCTTCCTCTTCCTCTCACTCTCTG 
                 574 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGGCATCGAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 16 
                 X 
                 − 
                 7 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAAAGTAAGGCAGACCATCATG 
                 575 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAAAGGCAGGGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 16 
                 X 
                 − 
                 42 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTATAGCCCTGCTGTCTATTAATG 
                 576 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATTTGCTTACACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 16 
                 X 
                 − 
                 77 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATATACAAAAATAACAAAAAAT 
                 577 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTACCTTATAAAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 5 
                 18 
                 + 
                 −14 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTTTGTTTCATAGGTTAAGAGC 
                 578 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGCTTATGTGAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 5 
                 18 
                 + 
                 21 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTTCCGCATATGTTCTTCAGTTA 
                 579 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGCACAGCGAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 5 
                 18 
                 + 
                 56 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACAGCAAGAGTTTGAAAATATC 
                 580 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGCAGCAGAATACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 5 
                 18 
                 + 
                 91 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAGGAAACTCACTAAGTTCTGT 
                 581 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATAAGTTTAAGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 3 
                 12 
                 − 
                 −5 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACAGCACAATCTGGTATGAACT 
                 582 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCACGCCAGGGAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 3 
                 12 
                 − 
                 30 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTATTGCCTCTGCTGGTTGGGTCT 
                 583 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAAAGGCCATACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 3 
                 12 
                 − 
                 65 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTGGCAAATGGGCACAGGCATG 
                 584 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAACCCAACCTCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 3 
                 12 
                 − 
                 100 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTACCGAGATTTCTTTTCCCATG 
                 585 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAATCTGGCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 2 
                 6 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCAATAAGCCCTCTTCTGGATC 
                 586 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAACACTCCTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 2 
                 6 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGCCATTCTCCAACTGAACAAA 
                 587 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGTAGTGAAATACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 2 
                 6 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAGCTATTAAGATGGAAAGATA 
                 588 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAAAGATAATTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 2 
                 6 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTACTGATTCAAGGGAATTGTAG 
                 589 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAGCTGCCGTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 2 
                 6 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGGATGACTATTGAGTAAGCT 
                 590 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAAACTCTTAAAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 24 
                 13 
                 + 
                 −54 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAAATTGTATATGGTTTTTTATT 
                 591 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTAATTGGTAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 24 
                 13 
                 + 
                 −19 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATTGATACTAAGATTCTGTCAA 
                 592 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTAAGATGAAAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 24 
                 13 
                 + 
                 16 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTGAATCATTCGGGGTGAGTAT 
                 593 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTCTTTCTATGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 24 
                 13 
                 + 
                 51 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTCTTTTATACTTACAATGCATA 
                 594 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTATTATATTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 11 
                 2 
                 − 
                 −14 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTGTCATTCCCAGTGCCTTCCCG 
                 595 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATCATTGGAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 11 
                 2 
                 − 
                 21 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACAGAGACCAGAAGGACTGTG 
                 596 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGTTAGCCCCATACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 11 
                 2 
                 − 
                 56 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCGGGCAGTGTGGTGCTGGTGGT 
                 597 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATTCTCATTGCACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 11 
                 2 
                 − 
                 91 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTTCAGTGCTTACCTCCGGCTG 
                 598 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGACAAAAGCTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 12 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAAATGACGGGCAGTTCACCGT 
                 599 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATCCAGCTTGTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 12 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTTCATGCCAGCAGCGATGCCC 
                 600 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGAGCATACCCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 12 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCTGGCTGAGATGAATTATGTG 
                 601 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATCGGGACCTGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 12 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCAGGTTACTGTTGACCAGAAT 
                 602 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTCCTAGCAGCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 12 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGCAAGGTGTCCGACTTTGGCC 
                 603 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTCCCGCTACCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 12 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGGTGTAGGTGGGATCTGAGG 
                 604 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTCATCCTGGAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 12 
                 3 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCTTGGTGAGTCCTTCTTGGCAT 
                 605 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTCAAGTAGAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 26 
                 13 
                 + 
                 −45 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTATAAATACACATGAAATGT 
                 606 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTGCATTTTTTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 26 
                 13 
                 + 
                 −10 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTGGACTCTCCTGGGAGATGTTT 
                 607 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTGCAGATTAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 26 
                 13 
                 + 
                 25 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTCAGCAGAAACTGGCAGAAAT 
                 608 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGTAAGTACTTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 26 
                 13 
                 + 
                 60 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAACAATTGTTTATTTCATTTACA 
                 609 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAGGTGAAAAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 12 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGTGTGCCGACCCTGAGAACCA 
                 610 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAAGGTCCGCCAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 12 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGGAACTCGTCCCACTCCTTG 
                 611 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCTTCAGTTTCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 12 
                 19 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTAAGGGGAAGCGCTTTCGCGTC 
                 612 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGCAACCTGTGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 12 
                 19 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGTCTCTGTCAGCCGCCCACAC 
                 613 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAGCCGATCTTACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 12 
                 19 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCAGGCGATGACCTGAAGGTAC 
                 614 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCAGCAGTTCGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 12 
                 19 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCCTGGGCCGGCAGGGTCTCCA 
                 615 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAAGCAGGCTGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 12 
                 19 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGCAGACGCCCAAGGCCTCCAA 
                 616 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCGGGAGAGGAGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 12 
                 19 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCCTGGCCCCGCCCACACTCA 
                 617 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTGCTCGTCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 10 
                 3 
                 + 
                 −7 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAACAGTAAAACTTCCAGGTCT 
                 618 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGGACTTATGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 10 
                 3 
                 + 
                 28 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCTTGGGTAGGGTCTTCATAT 
                 619 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTATGTGGGTCAACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 10 
                 3 
                 + 
                 63 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCATGAGTTTGCCAAGGAATTG 
                 620 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATGCCACCAACACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 10 
                 3 
                 + 
                 98 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGTTACCTGCTCCAACAACTTTA 
                 621 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAATGGATATACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 4 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTGTCGACCAGGTTTCTACAAG 
                 622 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCATTGGATGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 4 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAACTGTGAGGCGGGCACTTAGC 
                 623 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACACTTCATATTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 4 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTACTCAGGAAGATGGTTCAATGA 
                 624 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTGCAGGTGTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 4 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGAGGGTCTTTGTCTGCCCGGA 
                 625 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTAATTATTCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 4 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCATGGCTTGTACCCGTGAGTA 
                 626 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTTTGCTGCAAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 10 
                 13 
                 + 
                 −15 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTTTTTCTTTCAAGGTTGAAAAT 
                 627 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTTCTAAACGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 10 
                 13 
                 + 
                 20 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTAGATCTTTATTTTTAAGATAAA 
                 628 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTCTTCGTATACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 10 
                 13 
                 + 
                 55 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGCAAGATTATTTTTGGATCAT 
                 629 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATAAAACTCTTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 10 
                 13 
                 + 
                 90 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTACCATGTGCAATACCTGTCTAT 
                 630 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAATCAGTCTGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 15 
                 3 
                 + 
                 −16 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTTTTTTTTAATCAGGTACAGAT 
                 631 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAGTTTTTAGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 15 
                 3 
                 + 
                 19 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCATCCATGAAATCTGGTCGCC 
                 632 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCATTTGCTCAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 15 
                 3 
                 + 
                 54 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTACAGGGCTTTCTGTCTCCTCTA 
                 633 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACCCTGCTCAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 15 
                 3 
                 + 
                 89 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACCCCCAAGAAAGTACCTGAGG 
                 634 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTCCTAGTTGAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 8 
                 3 
                 + 
                 −16 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCTTTCTCACCTAGATGATTAC 
                 635 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGTCAGAGCTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 8 
                 3 
                 + 
                 19 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGCCGAGCCAGCAATCAGGGGC 
                 636 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCTGCTCCCTCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 8 
                 3 
                 + 
                 54 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGCCGGGGTCGTGTTCGTTGTG 
                 637 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCTTGGTGGCCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 8 
                 3 
                 + 
                 89 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGTGGAGGACCTACCTGCTACA 
                 638 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACGATAGAGATACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGGAAGAATTAGTGGTTTGGA 
                 639 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAGAACTATACACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCATGACTTGGCACACCTGGTAT 
                 640 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTCGTATCGGGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCCCAACCAAAACAACTGGCTG 
                 641 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGACTAACTGGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTACAAAAATCCTTTGTGCATTG 
                 642 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTTTGGAAATACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTGAAATTCACCCTGAGGGATT 
                 643 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTAACAGTCTTCACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTAAATGTTTCCTTGCAAGTTCC 
                 644 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGTACTCCAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGTACTATTATGAAACAGACTA 
                 645 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGACACTGGCAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTCTATTTTTACATAGAGGTTTT 
                 646 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTTATATTCACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCATTGCTGCAGATGAAAGTTTT 
                 647 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCCAAGGTGACACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCTCAGTGTTAAGCTTCATCTTT 
                 648 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTTCACCAAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGAGAGATTGGACCTTTGTCCA 
                 649 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAGGGATTCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCTATGCAAGCCCCTACATCCT 
                 650 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAAGGCAAGATACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGGTTTCTGTCAAAGTGTACTAC 
                 651 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGAAGTGCTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATCTGGAAAGATAGCTAAGTTC 
                 652 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAATAATGGACACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 490 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGTGACTGGTTCAGAATTTTCCT 
                 653 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTTAGTCGAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 525 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTTCCTCTGCACTGCTGACACAT 
                 654 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCCCTCGAACACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 560 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCGGAAAACGCCCCCAGGATGC 
                 655 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTGCAGTGCAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 595 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATACATTTTCCAATGGGCACTA 
                 656 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCATTCTCCTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 630 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCAAAGCAGGCTACCAGCAAAA 
                 657 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGAGACACTTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 15 
                 6 
                 − 
                 665 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTGGAGTTTTAATAGGACACAT 
                 658 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACTTACGTTCAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 8 
                 16 
                 − 
                 −34 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGTAGACTAATGATGTGACTTT 
                 659 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTTTTCACAGAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 8 
                 16 
                 − 
                 1 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATGCTATCAGAAGCAGGAAGCT 
                 660 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGCTGTTTCAGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 8 
                 16 
                 − 
                 36 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACCCAGGCAACCTACAATTGGT 
                 661 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCAGAGTTAAAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 8 
                 16 
                 − 
                 71 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACACGAGACACTGGAAGAGAA 
                 662 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATTCTTCTGACCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 3 
                 10 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCGCGGCTTTCCCCTGCTCACC 
                 663 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCTACCTCAAGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 3 
                 10 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCGCCCTCACGAAGGGATGTGGG 
                 664 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGACAGGAAGACACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 3 
                 10 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGCCAGTGGCCAGGCTGTGCCC 
                 665 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCGTATACTTCTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 3 
                 10 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGCTGCAGGCTGGAAAGGAG 
                 666 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGTTGAAGAAGGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 3 
                 10 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCAAGCCCCGGGAGCTCTGCTT 
                 667 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCAGAGACAAGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 3 
                 10 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGGGGTCGGTTCTCCCGAATG 
                 668 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGAAGGAGGGCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 3 
                 10 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCACCTTCCACCAGTTCCGCCTG 
                 669 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGCCTGTGCAGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 3 
                 10 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCCTGTAGGCCACGCTGATGTT 
                 670 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGGCACAAGAAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 3 
                 10 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTGGAGGGTGAGTGCCGACCTT 
                 671 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGGGCCGCCCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 4 
                 15 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCCCATGGGCCAGATGCAATGA 
                 672 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCTTGTGGATGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 4 
                 15 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGCCCCAGCTCACCCTTGGCCT 
                 673 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCGTGGCTGTCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 4 
                 15 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCCAAATGCTCCACATTGCCAG 
                 674 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAGATCGCCTCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 4 
                 15 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCACAAAGTGCTGGGAGGCCAG 
                 675 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTACACCATACCCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 4 
                 15 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCGAGACCTGGCCACCAGGAAC 
                 676 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCCTGGTTGGAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 4 
                 15 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGCCGAAGTCCCCAATCTTCAC 
                 677 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGCAGATTCGCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 4 
                 15 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCCAGAGATGTCTACAGCACGG 
                 678 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTATTACAGGGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAAGAAAAGTCGTCATCAAAA 
                 679 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAGGATTCCCTTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCATCCAAGGATAAATAAGCACT 
                 680 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTACTCCAAGAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGATGCTTTCACGGCTCCATTTCA 
                 681 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGGGATGGAAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTGAGAAAAGACAGTAGTTGCT 
                 682 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTAAACTCAGCAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCACAGACTTTCAGTTACCTGA 
                 683 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAAGACTTTGGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGAGCAGGACTTCACTTTTTCA 
                 684 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCTTAAGAGGTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAAACCAGTGGAGCCCTTTGAG 
                 685 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAAAAATGTTTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAATACAGCTTCCCTCTTTAAG 
                 686 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGTCTCTCTCCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCAGAGGAACTGAGTCCTAAAC 
                 687 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCATGGATACAGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGAACAATAAGGTCCTCTTCTA 
                 688 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTCCTCCATTTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGGAAAATCACATCCCAAAAG 
                 689 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCAAACTCGCAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGATGAAGAAAGGCCCGTCTTT 
                 690 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTATGCTGGCTTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATTACTTTATACTCCTTTAAATA 
                 691 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGTTGCGCCTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAACACATGTCTGTGGTAGGCCT 
                 692 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCATTATCATCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 490 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCTGCTTTCCCCATCTTAGGTAC 
                 693 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACTCCAGCCTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 525 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTAGATGCTTTTTCATAGGAGC 
                 694 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTGAGGGCCAAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 560 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAGTTGCTGGACGAACTTGCTG 
                 695 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACACCCCAACTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 595 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACTGGCAAGACAGACTGAGTCT 
                 696 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCAAATGAGCAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 630 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATACTAAACAATTCGACAGTTCA 
                 697 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCAGCCCAGCAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 665 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCCTGCCTGACACTTGCAGGGT 
                 698 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTATGTGGTTTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 700 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGACAACCTACCTGTGACTGTG 
                 699 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTCTGTCCCGCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 735 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAAGTGAATGACTCAATGGGTG 
                 700 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGGTGTTCCTGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 770 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAGAAAATCAGCTCTGTAGAAA 
                 701 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACATGCCAGGAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 9 
                 16 
                 − 
                 805 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGATTGTACCTGTTCGACGGAA 
                 702 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTTTATGCAGCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 12 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCACCTTCCGCAACCCTGTCATT 
                 703 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGAGGATTCCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 12 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTTGGAGAAAATTTTCTTCTGCC 
                 704 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCGGAGCCGAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 12 
                 19 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCAAGGTGAGAGGGTGCTCCAG 
                 705 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTTCCTGGGGGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 12 
                 19 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACCCTCCATGACACTCCCAGGA 
                 706 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCCTGGCCTCTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 12 
                 19 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACGCCTGCCCCGTCCCCCCAGGG 
                 707 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGGCGTTCCAGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 12 
                 19 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACGTGGCGACATCGATGTTCAT 
                 708 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGCCTAGCACGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 12 
                 19 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTGCGGCTGCTCCGGAGGCTCA 
                 709 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCCCAATGCCAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 12 
                 19 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGAGAAGCCCCAGGGCTAAAG 
                 710 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGCCTGTGCCCGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 12 
                 19 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGATCCGAGGCCCGGACCACGGG 
                 711 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTAAGGAAGGAGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 12 
                 19 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCAGGCTTCAAGGGGCAGCCGG 
                 712 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACCATGGGGCCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 12 
                 19 
                 + 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGGTCCTGGGTCCCAGACACAC 
                 713 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTCCTCTCGTCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 12 
                 19 
                 + 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGTTCAGCTTCTCCACCGATAT 
                 714 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCACTGCAGCAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 12 
                 19 
                 + 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGCACTGACTCGGACAGCTCAC 
                 715 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCAGAAGAGCTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 12 
                 19 
                 + 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACCAGGCTCGATGGGCTGGAAG 
                 716 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGGATCCCGCGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 7 
                 15 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCCCGTGGCTGTCATCAGTGGT 
                 717 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGGAGGACTCAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 7 
                 15 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGATGCCGTGGTTGATGTGGTG 
                 718 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGTGGGCTGGCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 7 
                 15 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACGCCCTCGTCACTGGATGCCG 
                 719 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCCCGACACTGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 7 
                 15 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCAATGACAGGGATGCGAGTCA 
                 720 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCCAATGACCAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 7 
                 15 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACCCCCAGTACTTCCGTCAGGG 
                 721 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACACAACTGCCAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 7 
                 15 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCATTCCATCCCAGTACTTACAC 
                 722 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGTCCGGCTTGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 14 
                 1 
                 + 
                 −4 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACAGATTCCCCAGGCATCCCCCC 
                 723 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGCGCTGGGGCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 14 
                 1 
                 + 
                 31 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCCACGAAGCTGAAGCCCCGG 
                 724 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACAGCTGATGGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 14 
                 1 
                 + 
                 66 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGGCCTGATGGAAGACGACGGC 
                 725 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGCCTCGTGCCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 14 
                 1 
                 + 
                 101 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCACCTGTACCACCGAGTGCAG 
                 726 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGTGCCTGCGGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGTTCCTGGGACTCGGGCGCTT 
                 727 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCTCGCCTTGTACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCCCAGCAGTTTCCTGAAAGCC 
                 728 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAAACCAGAGAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCATGGCCTTGCATCTGCCAAG 
                 729 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCCTGTGGTGCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCTGCGGAAGGGACATGACAGA 
                 730 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGAAGGCACAAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTGTGGACACTCCCCTACAAGA 
                 731 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGGGGTGGTGGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCCTTTGAAAACAGCGAATCAC 
                 732 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGCCCAAGGGCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGCCTGAGGTTGCTGCGCGATT 
                 733 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCCATTGAGCGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATAACTCAGGTCAAAAGATGGG 
                 734 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCCGGTTGATTACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTTTGAATACGTGATTCTCAATG 
                 735 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGACTGCCAGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGTGGGAAATGAAACTGGAGA 
                 736 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGCCCTCGAAGTACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGATGGCCTCAGGATTTATTG 
                 737 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACCTACCAACCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTTCCCAGGAGCGAGGCTGCCT 
                 738 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGCAGTAGCCAGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCTGGGACAAAGGAATTTTCTC 
                 739 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGGGCTTGTGTACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCGGGTAGCTAATTTTATTGTCTA 
                 740 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTCATAATTCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 490 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTTTTCTCGGACACTCCCTTCTC 
                 741 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCATCCGGGTGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 525 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAGCCCACTGGAAATATTTCAT 
                 742 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACAGTTACAAGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 560 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCTGGAGTCATTTCCTCAGATG 
                 743 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGACATTTGGGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 595 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGAAGAGCACTTGCGACTCGAT 
                 744 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGCTGTATGCAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 630 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCCACGGCTTACCTGTAGGGGT 
                 745 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGTCCTGACCACACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 665 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGGGCTTTCCGCATGCTTTGG 
                 746 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGTCTTGTCCTACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 19 
                 X 
                 − 
                 700 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGAGGATTCACCAGGCAGACAG 
                 747 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATTCGCAGTGAGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTAGTAACGGGGGCCACACTAG 
                 748 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGACTACTCTTCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCGGTGACCAACATTCGGTGAG 
                 749 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACGGGAGGGAAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCTCCGAGCCGAGGCAGCTGCA 
                 750 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGCTGGATTGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCTTGGCTGCCCGGTGCAGGGA 
                 751 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCTGGGGTGCTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGGACCAGCCTTTTTGCGGTAT 
                 752 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGACATGGACAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGGTCATGGGGGACAGGAGG 
                 753 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGGGGGTCAGCAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCATCTTCCCTAGTCCCTAGACTC 
                 754 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTGTTGGGCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTGATGTGACGATAGGGAAGAT 
                 755 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGATGAAGAAGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTATCCCTCTATCCATCCTCAAAC 
                 756 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGATTCCAATAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCGGAGTCACTACCCCGACGA 
                 757 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCTGGAATGGTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACGAAGCTTGGATAGTCGGGGA 
                 758 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGACAACAGGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCACTCACCTGTTTGATGGGGAT 
                 759 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCTCGCCCACTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCAGGGGCTGGGACAGGCTAGG 
                 760 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCAGCTGGTCTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGGGGAAAGACACATGTGGGA 
                 761 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAAGCCAACTAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 490 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCCAGAGCTTCCTACTAAAAC 
                 762 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAGTGGCAATTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 525 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTTACATATTTCTTCTTCCATTC 
                 763 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTGTTCAAGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 560 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGTCCAGTAATGGCTTTCTACTC 
                 764 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACCACCCCAGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 11 
                 12 
                 − 
                 595 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAATGTGGCCCAGTCTCTGCCA 
                 765 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCACGTTAATAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 8 
                 18 
                 + 
                 −18 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTTTTTCTCCCCTTAGAAATGA 
                 766 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAAAGTTTCCACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 8 
                 18 
                 + 
                 17 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCATTAGGATTATGTTGTGGATG 
                 767 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTTGAAGACTTACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 8 
                 18 
                 + 
                 52 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAATGAAATTCTAGTAGCTGACA 
                 768 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTATGACCAAAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 8 
                 18 
                 + 
                 87 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCAGTATCTTGCTTACTGGCCAT 
                 769 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGAGATTGACACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 19 
                 4 
                 + 
                 −18 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGTGGGCTGGATTGTAGGGTGA 
                 770 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCCCATGTGGAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 19 
                 4 
                 + 
                 17 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATGCAGGGGTGTGGTTCCATCG 
                 771 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGGTAGTACTGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 19 
                 4 
                 + 
                 52 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGCAGCTGGGAGAGGGTCCACC 
                 772 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGCTGGCAGCTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 19 
                 4 
                 + 
                 87 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCCAGATCACCATCTTACCTGC 
                 773 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCTTTGAGAAGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 6 
                 X 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGACCATTGGAGATGCCTACATG 
                 774 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGCTTCAGGCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 6 
                 X 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCAGCTGCATGCCTACTGCCATTC 
                 775 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTTTGGGAGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 6 
                 X 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATTGCAAACATGTCCTTAGATA 
                 776 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCTGAGCTCTGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 6 
                 X 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACTTCTGGCATGTGCCGCATCTT 
                 777 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAAGTGCCCAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 6 
                 X 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGGTCCGAATTCGAATTGGCCT 
                 778 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCACTCAGGTAAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 3 
                 13 
                 + 
                 −12 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTTGTTCCCAGGGAGGTTATATT 
                 779 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAAAGAAAAAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 3 
                 13 
                 + 
                 23 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGCTGCAATAAAGATACAGATT 
                 780 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCCACAGTTCCACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 3 
                 13 
                 + 
                 58 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGACCTAGATGAGATGTCGTTC 
                 781 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTTTTACTGAGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 3 
                 13 
                 + 
                 93 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGAAACTTTACCTGATTTCTAT 
                 782 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTTTTCTGTAGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 8 
                 1 
                 + 
                 −51 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACCCACACGGCCACAGCTGAGG 
                 783 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCCCTGACCACACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 8 
                 1 
                 + 
                 −16 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCCTCATCCAGAAGGATGCTGT 
                 784 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATAGAGAAATAACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 8 
                 1 
                 + 
                 19 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCCACATCAAACTCACTGGTGA 
                 785 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGAGGGCGCCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 8 
                 1 
                 + 
                 54 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTTGTCCTGTCCTCCCCTGGGTC 
                 786 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGAGGGGGCAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 14 
                 18 
                 + 
                 −8 
                 + 
                 7 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTATTTAGGATGGCAGTCAGTCA 
                 787 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAATTAGGAGGAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 14 
                 18 
                 + 
                 23 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAACCAATGTACAGTCCATGTCC 
                 788 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTGTCTCTCCTACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 14 
                 18 
                 + 
                 58 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGAAACCGTTCTCTTAAAAATG 
                 789 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGAAGCAAGAGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 14 
                 18 
                 + 
                 93 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAACAGATCTTACTTGAACTTTTT 
                 790 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTCCCTTCTGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 4 
                 12 
                 − 
                 −4 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGGCGGGAGGACAAACTGCG 
                 791 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATCCAGAATGGCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 4 
                 12 
                 − 
                 31 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCGGATGATCTCTGGTGCCAG 
                 792 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGCATAGCCAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 4 
                 12 
                 − 
                 66 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGTCCCCCGACACAGAGGAGG 
                 793 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATAAGCTCCCCTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 4 
                 12 
                 − 
                 101 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTACCCAAGGGCAAAGACGTCAG 
                 794 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTGCTTGGAGAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 3 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTTTGCTATCGGCATGCCAGTGT 
                 795 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGAATTTGATACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 3 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTCGGAAGTCCTGTACTTCTGG 
                 796 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCTTTAACCATACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 3 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAATATTCTGAACGTTTGTAAAG 
                 797 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGCTGTGGATCACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 3 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATTGCTCTACTATGAGGTGAAT 
                 798 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAGGTCCCTAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 3 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATGTCTATCCTCCAAATGTAGA 
                 799 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCTTCACCAGAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 3 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTTATCTAATTTATTATATATGT 
                 800 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTTTGGCAATACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 3 
                 3 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTAAGAAAATGACTAATCTACTC 
                 801 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAATCATTACTAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 6 
                 12 
                 − 
                 −22 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCTTGTCCTTTTGCTTTTCAGCC 
                 802 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTGTAAGGGAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 6 
                 12 
                 − 
                 13 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTTGGCATCCCTCACAACGGA 
                 803 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATAGAGCGTCCGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 6 
                 12 
                 − 
                 48 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGTTTTGGATGTCAACAAAACCA 
                 804 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCAGATTGCTCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 6 
                 12 
                 − 
                 83 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGCCCAAGAGCCGACAGTACCT 
                 805 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCACAATTTCTTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 9 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGAAGTCAGCACTGTGCTTAAG 
                 806 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGGATAACACAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 9 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGCCACATGGCTTCCAAGACGT 
                 807 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGCCCCACCACACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 9 
                 19 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAATGCCTGGGACCAGAGCTTCA 
                 808 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTGGAGCTGGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 9 
                 19 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGGCCCTGCTGTCCTCCAACGC 
                 809 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCTCACCCTTTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 9 
                 19 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGGAGGAGGGGTTCCATGCCTC 
                 810 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGCACCCTGAGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 9 
                 19 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCCCGTGCCTGGAGGGAGAGGA 
                 811 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAGGGCCATCAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 9 
                 19 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGAGTTGGCTGTGTTCTGGCG 
                 812 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGACCAGCGGGGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 9 
                 19 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATCCTCCAACTTCAGGAATTTG 
                 813 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGGCACACAGGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 9 
                 19 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTTGGACAATGAGAGGCATGAG 
                 814 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGCAGCTGGACACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 9 
                 19 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATACCTCAGCCACCAGGCAGCC 
                 815 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGGGGTTCCATACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 10 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGATGTCGTCATCGTGGAGCGTG 
                 816 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAAGGGCGACGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 10 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTCATCCTGCCAAACTTCCTCCT 
                 817 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCGGGAACACACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 10 
                 19 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCCTGCAGTTCTGTGAGAACCA 
                 818 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGGCCTGCCTAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 10 
                 19 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGATGAGTGCCGTCTTCTTATTCC 
                 819 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGTACCCCAGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 10 
                 19 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGCGCGAGACCCCTGGGCCCAG 
                 820 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACACGGTGAGCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 10 
                 19 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAGGAGGTACGGGGACGGAGG 
                 821 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACTCTGGGGCTAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 10 
                 19 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGTGCCCCTTTCCTCCAGCCCCA 
                 822 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGACAGTTGTACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 10 
                 19 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGGAGCTTCTGAGAAAAGAAA 
                 823 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACATGGGACTCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 10 
                 19 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTATGAGGTGGACAGTGATGAG 
                 824 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGTGGGAAGAAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 10 
                 19 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCTCACTGTGGGACAGGGACTC 
                 825 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCAGGCTCCTCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 10 
                 19 
                 + 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTAAGGATGTGCCCCAGCTGTC 
                 826 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCACTCACAGAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 22 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTTATGAAAAAATTCACCTGGA 
                 827 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTCCTGAAGAGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 22 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTCCACACGCATGCGTGCCACA 
                 828 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAGGATGGTCAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 22 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGACAATGCATACATTGGTGTC 
                 829 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCTACAAAAACACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 22 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGACCACCCTCCCAGTCCTTCAG 
                 830 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTGTCTTCCTCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 22 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGATGAGCAGAGACTGAGCGCTG 
                 831 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAGTGGCTACAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 22 
                 4 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCAGGGACAGGGTCAATGTCAG 
                 832 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAGAGGAATGAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 22 
                 4 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGGAGGACCTGGGCAAGAGGA 
                 833 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAGACACAGGTAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 19 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTTTATTCCGCCTGCGTGGTGCT 
                 834 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGCCTACAGTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 19 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACACACCTGTAGACGATCTTGT 
                 835 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTCGTGAAGAAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 19 
                 19 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGTGTGTGCATGCATGTGCACAC 
                 836 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCCCGTTGTGGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 19 
                 19 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAAAGAGGGATGAGCGGGGGT 
                 837 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGGGTCCTGTCCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 19 
                 19 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCCCTCCAACCCCCAACAGGGA 
                 838 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTGAAGTTGGAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 19 
                 19 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTTGACGTAGCCCTCGGTGTCC 
                 839 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGAGCAAATTGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 19 
                 19 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCGCAGACTTTGGCCTCTGCAAG 
                 840 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGGGTGAGGGGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 19 
                 19 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCCTTCCCCCTCCTTTGTCTAAT 
                 841 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAGAGGCCAGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 19 
                 19 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGGGTCCCTAACCCTATTCGGG 
                 842 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGCCCCCCACCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 19 
                 19 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTTGTCCACACAGCCAGCCCTG 
                 843 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCCAGGGTCAGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 19 
                 19 
                 + 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCACATTGGGCTGAGTGACTCCT 
                 844 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGGCCCCCATAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 19 
                 19 
                 + 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCCCATCCCTGGGGACAGCAAG 
                 845 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCATGTGAGGTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 19 
                 19 
                 + 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGGGGACCGGACCAGCACATTC 
                 846 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTGGGACCCCGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 19 
                 19 
                 + 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACGTGTCCGTCAGCACCTCAGG 
                 847 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCCAGGAACTCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 19 
                 19 
                 + 
                 490 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTACACGCGAGCTGTGGACTGGT 
                 848 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGGACTGGGTGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 19 
                 19 
                 + 
                 525 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCACCTCGCCAACCAGCATCT 
                 849 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGTAGAGCAGCAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 10 
                 6 
                 − 
                 −16 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTCCTCTGTTTACAGCTACAGCT 
                 850 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCTCCAGTGAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 10 
                 6 
                 − 
                 19 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCAACCACAGCAATGATAATA 
                 851 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAGGATTCTGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 10 
                 6 
                 − 
                 54 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGCTGGGACCATCATTTTGGTG 
                 852 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCATGGTCTTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 10 
                 6 
                 − 
                 89 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACTTTGTGTTCTACCTTCTCCCA 
                 853 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGATGAAGCCACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 11 
                 3 
                 + 
                 −29 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTATGTTTATTTTGTTTCTCCCAC 
                 854 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAGACACTAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 11 
                 3 
                 + 
                 6 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAATTTGGGTAGAATTTCGGGG 
                 855 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATAGTTACACAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 11 
                 3 
                 + 
                 39 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTTCTGTCTGTTAAATGGAATTC 
                 856 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGAGATGAAGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 11 
                 3 
                 + 
                 76 
                 − 
                 0 
                 0 
                 2 
                 0 
                 CGCGAATGCCTTATCTAGTAATCTCAAACATAC 
                 857 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTTACCTGGGCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 10 
                 15 
                 − 
                 −58 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTGTCTGTTCTGGTTTTTATTAA 
                 858 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTTGTTAATTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 10 
                 15 
                 − 
                 −23 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATCCGTGCTCTCTGCAAAAAAA 
                 859 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGACAAAGAGATACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 10 
                 15 
                 − 
                 12 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTTTATCTTGTGTAAGTCTGCTT 
                 860 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACCTGTTGCTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 10 
                 15 
                 − 
                 47 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGTTACCGATAGTATCAGAATA 
                 861 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATCAGTTTCAAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 9 
                 18 
                 + 
                 −21 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGTTTATTATTTATTCTTAGAAG 
                 862 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACATGGAACAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 9 
                 18 
                 + 
                 14 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAATTAAAAGATGACTTATCAGG 
                 863 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTATAGCTGCTACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 9 
                 18 
                 + 
                 49 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCTACAGTTGTTGCTGAAACAC 
                 864 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGGACTTGGTGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 9 
                 18 
                 + 
                 84 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAAACTAAACAATTACTTACAG 
                 865 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTCTTCTTGAAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 8 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCCTGGCCGGCTCCTGTGGGAA 
                 866 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTTGCCCCCTTACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 8 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCGAGGGGCCAGGACCATGTGC 
                 867 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTTTAATTTCAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 8 
                 19 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCGGACCGCTTTCCATCCAGAC 
                 868 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTGCAGTCAGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 8 
                 19 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACTCGCCGCTCTGCTGCTGGAG 
                 869 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGCTGGTCCAGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 8 
                 19 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCCTTCTTGAAAGACCTCAAAG 
                 870 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCGGCAGCCCCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 8 
                 19 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTCCGGGTGGAAACGTGCGTGG 
                 871 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCCGGACCTCAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 8 
                 19 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGATATTTTTAACAGGTCAGA 
                 872 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCTGAGGAGGTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 17 
                 1 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGTATGATGATGGCAAACACGT 
                 873 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTACCTGGTGACACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 17 
                 1 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTTGTCCAGCAGCTCCCCACCCC 
                 874 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCATCAGCTCTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 17 
                 1 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCTGCGGCAGAAGTTCTTCTCA 
                 875 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGCGGGAGGCCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 17 
                 1 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCACAGTTTTGCCAATGGTGTG 
                 876 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGGACAAAGCTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 17 
                 1 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTATCTGCACTCACAGGGGGTGA 
                 877 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCTGGATTCGGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 6 
                 6 
                 − 
                 −39 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGGTTACGACTCCTGAAACTTT 
                 878 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTTTTTTAATTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 6 
                 6 
                 − 
                 −4 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGAACTCTATTACTATCATGACT 
                 879 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTTTCCCTAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 6 
                 6 
                 − 
                 31 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAAAATGGAGCCCTAGATGCAT 
                 880 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCTCAGGGTAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 6 
                 6 
                 − 
                 66 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATAGTATATTTAGAATAAGTGGA 
                 881 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCACTTTGGTACACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 21 
                 13 
                 + 
                 −18 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATCAATTTATTTACTAGATTATG 
                 882 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGTGTTCCATACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 21 
                 13 
                 + 
                 17 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAAGGTCTATATTCTTCACTTTGC 
                 883 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATATGCCATACACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 21 
                 13 
                 + 
                 52 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATTCAAAATCATTGTAACAGCA 
                 884 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACAAGGATCTTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 21 
                 13 
                 + 
                 87 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATGGAAAATTACCTACCTCCTG 
                 885 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACAGCATGAGGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 11 
                 12 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACCACATCCCTGTCCCTTACCA 
                 886 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCAGACTCCAGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 11 
                 12 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGGCGTGGAGGACGTCGTGGA 
                 887 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAGGGGTTGCTGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 11 
                 12 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCGCCAGCACCCCCCCTCCCTC 
                 888 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTAGTGCCACGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 11 
                 12 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGCACTGTGGGGAAGGGTGTAG 
                 889 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGAGAAGGCGGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 11 
                 12 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACGGCAGCAGAAGAACTTCAACC 
                 890 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCCAGGTACCTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 12 
                 1 
                 + 
                 −38 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCAGCCAGGGACAGACCCTTCA 
                 891 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTGGGCTCTTTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 12 
                 1 
                 + 
                 −3 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTGATTTCCTCTGCCCCATCAGG 
                 892 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCGGAGCCTGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 12 
                 1 
                 + 
                 32 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGCATGTCTTCTACTCCACCATT 
                 893 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACTGGAATGTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 12 
                 1 
                 + 
                 67 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCTGGCCAGAGCCCTGGTGTGG 
                 894 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGACACACTCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 2 
                 16 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGCTTCTCTTTATTGTCCTGAGT 
                 895 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATCCCTGTGCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 2 
                 16 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAACACAGGGCTTCGCAACGAC 
                 896 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCACTCTCTTTGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 2 
                 16 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCTCATTGTGATTAACCCTAAG 
                 897 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACGACTCTCAGCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 2 
                 16 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCCCTGGAGGAAGACAGTACAG 
                 898 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATCACACCCACACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 2 
                 16 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCTGGCAGGCAAGTGTGCATAA 
                 899 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGCTACTCTATACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 16 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCATCAAACCTTCTTCTGGACC 
                 900 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAGCAATGTGGACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 16 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGCCAGTCACCTGTTGTGCGGA 
                 901 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGTAGTGATATACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 16 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATGGTGTCTGGACAGCACACTG 
                 902 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAGGAAATCTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 16 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTATTGTGTCACAAGAACTGTAC 
                 903 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCACACCCGTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 16 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAAGATTTCCACAGAGTAAGAA 
                 904 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAAAATTCATACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 12 
                 10 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGGATCCAAAGTGGGAATTCCC 
                 905 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCGGAAGAACTTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 12 
                 10 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAATTCGCCTTCTCCTAGAGTTT 
                 906 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCCAAGAACCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 12 
                 10 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAAAGTGGTCAAGGCAACGGC 
                 907 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTCCATCTGAAAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 12 
                 10 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCTTCACGGCCACCGTGGTGTA 
                 908 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCTGCTCTGCCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 12 
                 10 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGAAAGGTACCTGCCAGGCAC 
                 909 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGCACAGTGCCACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 27 
                 13 
                 + 
                 −33 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATGCTGTTAACAGTTCTTCATCC 
                 910 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTTTCCAGCTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 27 
                 13 
                 + 
                 2 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCATTTTCTGCTTTTGCATTCGT 
                 911 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTCGAGTAGAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 27 
                 13 
                 + 
                 37 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGATAGCATGGATACCTCAAACA 
                 912 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGAAGAGAAATACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 27 
                 13 
                 + 
                 72 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGTACACAGTGTCCACCAAGGT 
                 913 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTGAGATCCTCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 15 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCTCCCCCATCCAGGAATCCAC 
                 914 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCTCCCGAGCTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 15 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGCGGGGCCTGGGGTCTCCTGG 
                 915 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCTCCGAAGGCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 15 
                 19 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTGCAGGTGACACCACTCCCTG 
                 916 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCCCCTGTCCAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 15 
                 19 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCACTGGTGAGAACAAGGACAGC 
                 917 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGCAGGGGTGGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 15 
                 19 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCTCTCCACAGCCCTCTGAGG 
                 918 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGTCACCTCTGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 15 
                 19 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCAGCACCGCCAGGAACTTGAA 
                 919 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCTTCGAGGGTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 15 
                 19 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGGGGTCATTTTGGGAAGGTGA 
                 920 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTGGAGGGCAGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 15 
                 19 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGCCAGCCAGGGACCTGGGGG 
                 921 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCTCCCAATTCCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 15 
                 19 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTAAAACCACCCCTGCCCACTGT 
                 922 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTTCCAGGTGCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 15 
                 19 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAACAGCTCCCCACTGGGCCGGA 
                 923 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTCGGAGAGGAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 15 
                 19 
                 + 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCATCAAGGCTCTGAAGAAAGG 
                 924 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGACATTGTGGCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 15 
                 19 
                 + 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCACGGCAGGTCCCCACCTCTCC 
                 925 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCTCGTCTCGGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 1 
                 19 
                 + 
                 −44 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCGCCTCCGCCGCCTGAGAGGA 
                 926 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTCGAGCTGCCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 1 
                 19 
                 + 
                 −9 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCCCGCACTCCAGCTCCTCCAG 
                 927 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATCGCCCCGGCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 1 
                 19 
                 + 
                 26 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCCGGCGCCAGGGGAGCCGCCA 
                 928 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGGTCGGTTCGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 1 
                 19 
                 + 
                 57 
                 − 
                 13 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCGCGCCCCCCCTTCCCCTCGG 
                 929 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGCGGGCCCGAAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 11 
                 X 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCATGAAGTACTTACACCACAG 
                 930 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAGTTTGTTCAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 11 
                 X 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATCTACCACACAGTTTCGAGAC 
                 931 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTAGCCTCCCAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 11 
                 X 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCGTTTTGTACTAAAAGTGACA 
                 932 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATTATGGCTTTACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 11 
                 X 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTTCAGAGAGTCTCAGCATTTCT 
                 933 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGATGTCGTTACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 11 
                 X 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAATCTTCTATGGAAGGTAAGC 
                 934 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATGAATTGTACACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 8 
                 12 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATTACATCCACAGTACCCACGG 
                 935 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAGGAGATGGAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 8 
                 12 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTTGCCCGGGACTTTGACTGTT 
                 936 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTCGCAGCAAGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 8 
                 12 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCCCCCGAGGGCCATCTCTGCC 
                 937 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTGGCCCCTCAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 8 
                 12 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGCTCATGTCCTTGACGAGCCC 
                 938 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTAATGCTGGCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 8 
                 12 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTCCAGATGGGTGAAGGCCTGG 
                 939 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGAGTAAGGTTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 8 
                 12 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCAGCCCTGGCCCCTCTTCTGCT 
                 940 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTATGTCATAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 8 
                 12 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAAAAGAGGGGTAAGAGGGAA 
                 941 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGGGGGCTGGCAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 8 
                 12 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCCCTCTTTATCACCCAGCTTCC 
                 942 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACTCGCCCAGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 8 
                 12 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACATAAGGAATGGGGCCAGAA 
                 943 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAAGAGGCTCACACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 8 
                 12 
                 − 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTAGTGGCTTCTGTCGGAAGAA 
                 944 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATGAAACCTCAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 8 
                 12 
                 − 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCATGCCAAGCCCTAGCCCCAG 
                 945 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCCAGTTCCCTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 8 
                 12 
                 − 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGGTGTTTGGATGTCTGATCT 
                 946 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTGGTGGCTGCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 8 
                 12 
                 − 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAAGCCAGACCGGAATTTGGCC 
                 947 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGAGCCCTCAGCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 8 
                 12 
                 − 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGACAGCAGATGGAAGGTCATCC 
                 948 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCACTGACCCGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 8 
                 6 
                 − 
                 −7 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTACAGTTAAATTTCCAGGCAC 
                 949 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAAACCTACATACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 8 
                 6 
                 − 
                 28 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCTCTATTTGGGTCCTCATAG 
                 950 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTTCAGGGTCAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 8 
                 6 
                 − 
                 63 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCATCAATTCGCCAAGGAGCTA 
                 951 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATGCCTCCTGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 8 
                 6 
                 − 
                 98 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCTTACCTGCACCAATCACACG 
                 952 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCAATTTTAATACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 10 
                 3 
                 + 
                 −8 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAACAAGGCTCCCCAGGGATGA 
                 953 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGATCTACATTGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 10 
                 3 
                 + 
                 27 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACAGCTTCGTTGGGATCCTCGT 
                 954 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGTGAAGGGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 10 
                 3 
                 + 
                 62 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGGAGTTTGCCAAGGAGATTGA 
                 955 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTATCTTTTGTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 10 
                 3 
                 + 
                 97 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGCCATACCTGCTCCGATGACC 
                 956 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTTCAATTTTCACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 9 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAACACTGTCCATTGGCATGGGG 
                 957 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAATATAAACTTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 9 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTTTCCAGATACTAGAGTGTCTG 
                 958 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTAATCAAACACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 9 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCTTTGAATCTTTGGCCAGTAC 
                 959 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCATGGATTAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 9 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATCCAGTAACACCAATAGGGTT 
                 960 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGCAAATCTTCACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 9 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAATCCAAATAAAGTAAGGTTTT 
                 961 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATTGTCATAAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 9 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGAGAGAAGGTTTGACTGCCATA 
                 962 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAATATCTAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 9 
                 3 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATGTATATATAATAGCTTTTCTT 
                 963 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCATCTCTTAGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 9 
                 3 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACCAGTCAAACTCCAACTCTAA 
                 964 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCATGGAGTTTCACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 9 
                 3 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCAGTGTGGTAAAGTTCCCAG 
                 965 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATATGTCAGTGAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 9 
                 3 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCTCGGGATACAGACCAATTGG 
                 966 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATGCTCTTCAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 9 
                 3 
                 + 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGGATTTAGCTATTCCCACGC 
                 967 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGACTGGTAAGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 16 
                 10 
                 + 
                 −34 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAACTTCAATGTCTTTATTCCATC 
                 968 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCTCTTTAGGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 16 
                 10 
                 + 
                 1 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGATTCAATTGCCATCCATTTAA 
                 969 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGGAATCCGACACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 16 
                 10 
                 + 
                 36 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTTTTGATCATATCTACACCACG 
                 970 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAAGTGATGTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 16 
                 10 
                 + 
                 71 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACCTCCACCCCAAGAGAGCAAC 
                 971 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCCACACTTACACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 17 
                 3 
                 + 
                 −30 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAATGGTGATACATATTATTTGA 
                 972 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTTCAGATTTAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 17 
                 3 
                 + 
                 5 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATACGAATAATTTGAAGTGTTAG 
                 973 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATATCTTGCCGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 17 
                 3 
                 + 
                 40 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATGGAAAATATCTGGCAAAATC 
                 974 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGGTCTTGATCACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 17 
                 3 
                 + 
                 75 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAACATACAGGTTGCCTTACTGG 
                 975 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTACCTACCGAAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 4 
                 13 
                 + 
                 −10 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCTTTGTAGTGTCCATAAATTCT 
                 976 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTAACTTACTAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 4 
                 13 
                 + 
                 25 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCATTATCAACTTTGGTACTGGT 
                 977 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCAATTTCTTTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 4 
                 13 
                 + 
                 60 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATGTCAAGACTGTTGAAGAAGT 
                 978 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGATGTATTGTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 4 
                 13 
                 + 
                 95 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTACTTTACCTTTCCAATTTGCT 
                 979 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAGAGTGCAAACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 21 
                 1 
                 + 
                 −1 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGACCTGGTGTCCAAGATGCTAC 
                 980 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACGTGGATCCCCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 21 
                 1 
                 + 
                 34 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGCTGCAGAACCTGCTTAGCTG 
                 981 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAGGCGCTGGTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 21 
                 1 
                 + 
                 69 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCATGGGTCACCCAGAAAGACAA 
                 982 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTTCCCCAAAGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 21 
                 1 
                 + 
                 104 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTTCACAAGCTGTAGGTCCTGG 
                 983 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGGACAGCTGGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 3 
                 4 
                 + 
                 −30 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTGAAACATTTAAATGTTCTTCT 
                 984 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTACAGATGTTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 3 
                 4 
                 + 
                 5 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAAATATTGTATGAGTCAAAGAA 
                 985 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGATCCAAATGAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 3 
                 4 
                 + 
                 40 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCCAGAAGTATTTCAACCACAG 
                 986 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGGCACTGCCAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 3 
                 4 
                 + 
                 75 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACAACAGGGTAACAGGGATGAG 
                 987 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTTCTTACCTGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 17 
                 3 
                 + 
                 −17 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTTTCTTTTTTTACAGTGACATG 
                 988 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAAGGTTGGACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 17 
                 3 
                 + 
                 18 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGATGATCTTCTTCTGTGGCCCAA 
                 989 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCACGGTGACAACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 17 
                 3 
                 + 
                 53 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTAGCATTAAAGCTCTAGAAACG 
                 990 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAATCAAAGAATACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 17 
                 3 
                 + 
                 88 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACTTCCGTCCCGTGCTTTACACG 
                 991 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAACTGGGCCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001007156 
                 2 
                 15 
                 − 
                 −6 
                 + 
                 19 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCCAGGGGTCTTTTCAAACATA 
                 992 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACAATCATGGGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001007156 
                 2 
                 15 
                 − 
                 33 
                 − 
                 35 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGGACTAGATGATCTCTATTGT 
                 993 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTTCAAGTTTAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001007156 
                 2 
                 15 
                 − 
                 68 
                 + 
                 35 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCAACTCACTATATATATGAGGA 
                 994 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCTGAGGTCCAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001007156 
                 2 
                 15 
                 − 
                 103 
                 − 
                 35 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACCATGTGACCTTGGGTAAGAC 
                 995 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTTCCCCACTCACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 3 
                 2 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCTAACACTGCCTTGTTGGATC 
                 996 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAGCTCCCCTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 3 
                 2 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGCCAATCGCCCACTGATACCA 
                 997 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGCAGAGAATTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 3 
                 2 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGGCCATTAAAATGGACCGGTA 
                 998 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAAGGATAACTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 3 
                 2 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCACAGCCTCTAGTGTGGTATAA 
                 999 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAGCAGCTGTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 3 
                 2 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCACGTGAACCAGGAGTAAGTA 
                 1000 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCAACGATGTAACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 9 
                 3 
                 + 
                 −38 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCCTCTTATGTGTTCGCTTTCCTT 
                 1001 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATTTACCTCACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 9 
                 3 
                 + 
                 −3 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGCCCCATGTTTTGACTTATAGC 
                 1002 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACAGAACCTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 9 
                 3 
                 + 
                 32 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGAAAAAAGACTTCATTTTGGC 
                 1003 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATGGGCATTGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 9 
                 3 
                 + 
                 67 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTGAAGCAAAACAAAAAGCCA 
                 1004 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTTTAGAAACTTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 7 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAACACAATGAGTTCAACTCCTC 
                 1005 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATGGCCAGGAGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 7 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCGCAGCCCATCAATCCTTGCT 
                 1006 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGTTGGTCTGAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 7 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGCATGGTATATGTGGTACAG 
                 1007 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGCGTGCCCGCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 7 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCTTGCCACTGAACTTGCCGTA 
                 1008 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCAGCAACAGTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 7 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGCTTCCAGACTCTGACTGACG 
                 1009 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTAAGGGTCGGGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 19 
                 13 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTATCTTTCTCCTGTAAGATCTCC 
                 1010 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAGAAAAAAGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 19 
                 13 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCATTTGCAGTAGAATTTACAC 
                 1011 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCGTAGTTGAACACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 19 
                 13 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGACACAAGCAACCTCAGCCTT 
                 1012 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAGACCCAGAAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 19 
                 13 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATAAAACAGTGAAAGAGAGGT 
                 1013 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGATTTCAATGGCACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 19 
                 13 
                 + 
                 136 
                 + 
                 7 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATAAAAAAGGTTAGTAGATGAT 
                 1014 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATTTTCAAGAGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 18 
                 18 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATTATGCAGATATGCCAGCAGA 
                 1015 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAAAGAGAAAAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 18 
                 18 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCGGAATCGGTGTCTTGAGCAG 
                 1016 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAGCCAATTTCACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 18 
                 18 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACATTCCACCCAACACACCAGAG 
                 1017 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATTTTTGGGAAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 18 
                 18 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTTCCATACAAGTCTGAGTGGA 
                 1018 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGAAAACCAACACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 18 
                 18 
                 + 
                 136 
                 + 
                 9 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAGAGGTGAGAGTATAGATTGT 
                 1019 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACATTTTATAAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 8 
                 12 
                 − 
                 −46 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTGCCTTTTCACCTAGGGATCAC 
                 1020 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTTATTTTTCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 8 
                 12 
                 − 
                 −11 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAAGTAATGGATTTCCTTCCAA 
                 1021 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTGTAAAGAAAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 8 
                 12 
                 − 
                 24 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATTGAAGTGGAGCCAACGTCGG 
                 1022 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGTGAGAATCAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 8 
                 12 
                 − 
                 59 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGCAGTCCCTGGAAAATGTCGC 
                 1023 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCACTGCTCTCACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 10 
                 18 
                 + 
                 −10 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTCTTGAAGGAAACTCAAGGTC 
                 1024 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCATGAGCCCCCACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 10 
                 18 
                 + 
                 21 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTTCCAGACAGTGGTAGAGCTC 
                 1025 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCACCAAGGGGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 10 
                 18 
                 + 
                 56 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAATCACAAGAAACAGCCTTTTG 
                 1026 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGAATCTACAAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 10 
                 18 
                 + 
                 91 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCCCTTAATTACCTTAAACTATC 
                 1027 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCAGTATTTCACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 9 
                 13 
                 + 
                 −31 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATGATCATGTTGTAACTTCATCT 
                 1028 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTTCAGGTGAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 9 
                 13 
                 + 
                 4 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATAAAAGGTATAAAATTTTTGA 
                 1029 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATAAACATTTTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 9 
                 13 
                 + 
                 39 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATTCTCTTGGACTTGTAACATCT 
                 1030 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATGGACTTCCACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 9 
                 13 
                 + 
                 74 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAATATTTTATTAAATTTCCTTTC 
                 1031 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGATTACCTCTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 5 
                 10 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACACCGTGGTGGCCACGCTGCG 
                 1032 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTCTTCGATGCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 5 
                 10 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCTCACCAGCTCCCCTGATGCA 
                 1033 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTACCACGTCTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 5 
                 10 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTACACAAGCACGCTGCTCCCC 
                 1034 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGGACACCTGGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 5 
                 10 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGGGCCAGTGTTCCACCCGGAA 
                 1035 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTCTGCTGGGCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 5 
                 10 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGAGACCTCGGTCCAGGCCAACG 
                 1036 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAGCTTCGTGCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 5 
                 10 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGCCCCTCTTACTATAGTCATG 
                 1037 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACGGTCGCCCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 22 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTCTGGGCTGGGAAGCCCTGTT 
                 1038 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCCCGGCGCCTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 22 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCGGCCGGACAGCGTGGGCACA 
                 1039 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGGGCGGTGGCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 22 
                 19 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGACGTCAGCAACTTCGACGAG 
                 1040 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGTTCACCGGGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 22 
                 19 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCGCGTCGCGGGGCGGGCTCAG 
                 1041 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTGGGGGCCTCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 22 
                 19 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCCCTCACAGCCGCGGAGCAGG 
                 1042 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGCCTTCCTGGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 22 
                 19 
                 + 
                 171 
                 − 
                 3 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCTAGCAGCCCCCGGCCACGAA 
                 1043 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCGAAGTCCAGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 13 
                 3 
                 + 
                 −18 
                 + 
                 0 
                 23 
                 1 
                 1 
                 CGCGAATGCCTTTTTTGGAATCACCTAGGTCCTA 
                 1044 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAATATGAACAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 13 
                 3 
                 + 
                 17 
                 − 
                 0 
                 0 
                 2 
                 0 
                 CGCGAATGCCTCAGTAAAAATCTCACAAGCAAG 
                 1045 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTATCCAAATATACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 13 
                 3 
                 + 
                 52 
                 + 
                 0 
                 0 
                 2 
                 0 
                 CGCGAATGCCAGAAAGCATTGACTAATCAAAGG 
                 1046 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTGGGCACTTTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 13 
                 3 
                 + 
                 87 
                 − 
                 0 
                 0 
                 2 
                 0 
                 CGCGAATGCCGAAAATAATTAGACTTACTTTAA 
                 1047 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGCCAAAAGAAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 3 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCTGAGCCTAATCCTCTGCCAG 
                 1048 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTTCATTACCCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 3 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCACAACCTTTTCATTTTCATTT 
                 1049 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAAGGATAGAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 3 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGAATTCATCCTTTTCTCTGAG 
                 1050 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGCTTTGGGGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 3 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCAGACATGGGGTACTGCCAGC 
                 1051 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCACTTCACTCTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 3 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAGAGAGCTCCGATGTGGAAAT 
                 1052 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGAAATGAAGAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 3 
                 4 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTCCAAGACCGTCACAAAAAGG 
                 1053 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGCTGTTGTTTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 3 
                 4 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAGCAGTGCCTCGGCGGCCCAC 
                 1054 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAGGGTTGTACACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 3 
                 4 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCTCTTCTGTCTGAGTGTGGTTG 
                 1055 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAATAGCAAGTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 3 
                 4 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAGCTTGAAGGCAGGCACATTT 
                 1056 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACATCTATGTGCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 3 
                 4 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAGCTTGGTCCTGGAGACCCAG 
                 1057 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAACTCACCTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 16 
                 6 
                 − 
                 −38 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTCATGTAACATATGGAAATAC 
                 1058 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACTTTCTTTTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 16 
                 6 
                 − 
                 −3 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTTTGTTGTGCTTTAGAATCCAG 
                 1059 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGTAGTACTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 16 
                 6 
                 − 
                 32 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGTTGGAGTGGATTTCCTCTCC 
                 1060 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCCAATGGGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 16 
                 6 
                 − 
                 67 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTAAAAAAGTGATATTTTATGA 
                 1061 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAAAAAAACTTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 7 
                 12 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATGAAGAGGTCCATGATGAGGC 
                 1062 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGAAGAGTCAGAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 7 
                 12 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGAGGAGGGACAGGTTCATCTCC 
                 1063 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCGAAGTCATCCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 7 
                 12 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGCCCGGAGCTTCCCACGCAAG 
                 1064 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCAGCCAGACCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 7 
                 12 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCAAAGGGGATGTCCCACTCCTG 
                 1065 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGGAAGATGCTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 7 
                 12 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGCTGGAGATCGGCGAGCTCA 
                 1066 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGGAAAGGGCCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 7 
                 12 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCATGCCAGCGGCCGTGGTACA 
                 1067 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTGCCCAAAGCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 7 
                 12 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGGTGGCCATCCGGCTGATTGA 
                 1068 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATTGAGAGGGAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 7 
                 12 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCCCGCTTGAAGGCCTTGAGC 
                 1069 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGTCCTCGTTGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 7 
                 12 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGATGGCCTACAGGCAGACACGG 
                 1070 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATGAGAACGTGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 7 
                 12 
                 − 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAGGCGGGCTCATGCAGGCACC 
                 1071 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATGAAAAGCACACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 7 
                 12 
                 − 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTGGCCATCATCACCAGGTCAG 
                 1072 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCCACCTGGGCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 9 
                 X 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAATCATAAACAGACTTAAGAAG 
                 1073 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTCCTCCTGTGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 9 
                 X 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGGGGCATGCTCAGGAGGAA 
                 1074 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTACTGGTCTGTAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 9 
                 X 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGAATGTCTCCAGCTGATGAAGC 
                 1075 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTGCTGGGCTGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 9 
                 X 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATTTCATCAAAAGTTGGTCGTTG 
                 1076 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCTGCAGCCTACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 9 
                 X 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTAACCAGGTAAGGACTCTGAA 
                 1077 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTTATCATTGCACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 6 
                 18 
                 + 
                 −36 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATATTATTTGCCTTCTTTTTCAC 
                 1078 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTGTTTTTAAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 6 
                 18 
                 + 
                 −1 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTATTTTCTTCCTGTAGAGTATTC 
                 1079 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTTCATTCACACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 6 
                 18 
                 + 
                 34 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAGCTTTCTGAACAACTCCAGC 
                 1080 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAAAATTGAGTACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 6 
                 18 
                 + 
                 69 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATAAAATAAAATAACAAGGTTGG 
                 1081 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGAAAATACTTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 1 
                 13 
                 + 
                 −6 
                 + 
                 2 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCGTCATGCCGCCCAAAACCCC 
                 1082 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGAAAAACGGCACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 1 
                 13 
                 + 
                 33 
                 − 
                 35 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTGCCGGGGGTTCCGCGGCGGC 
                 1083 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCGGCGGCGGTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 1 
                 13 
                 + 
                 72 
                 + 
                 8 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGCCGCCCCCTCCTGAGGAGGA 
                 1084 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCAGAGCAGGAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 1 
                 13 
                 + 
                 103 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTGACGAGAGGCAGGTCCTCCG 
                 1085 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCCGCTGTCCTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 14 
                 4 
                 + 
                 −14 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATTCTTTCAACAGCCACGGCCA 
                 1086 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATCCAGTGAAAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 14 
                 4 
                 + 
                 21 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTCATTATCTTCAGTTCAGACAT 
                 1087 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGAGCTTGTTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 14 
                 4 
                 + 
                 56 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACCTGGGGCCACATTTGAACAT 
                 1088 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTAAACTTGCTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 14 
                 4 
                 + 
                 91 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTCAGTGAGCCCACCTGACTTG 
                 1089 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGCAGGCTCCCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 5 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATCAGGAGCGTCTGGGCAAGCA 
                 1090 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTCAAGTTACGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 5 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCTTTCAGCTTCTCCTTTTCTTC 
                 1091 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTTTCTGCAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 5 
                 19 
                 + 
                 66 
                 + 
                 4 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGGAGGCCAAGCGGGCCAAGG 
                 1092 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGAGGCCAAGAAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 5 
                 19 
                 + 
                 105 
                 − 
                 35 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCTCCTTTTCCTTAAGCTCCTTC 
                 1093 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTTCCTCCTTACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 5 
                 19 
                 + 
                 144 
                 + 
                 31 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGAAGCGGGAGAAGGATGAGA 
                 1094 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGAGAAGGCGGAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 5 
                 19 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTGCGCCGCTCCTCCTTGAGCCG 
                 1095 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGCTTCTCCGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 5 
                 19 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGAGACAGGAAGCCCTGGAGT 
                 1096 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGTGTCCTTGGAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 2 
                 4 
                 + 
                 −54 
                 + 
                 17 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTCATTCTAGTGTTACAGTTTTG 
                 1097 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTTGTTTTGTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 2 
                 4 
                 + 
                 −15 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATGGATCATCTTCTGCCATTCTG 
                 1098 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGCTGTGTATACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 2 
                 4 
                 + 
                 20 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTGGGAAGGCCTGAACAAGTAA 
                 1099 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGTCATAATCTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 2 
                 4 
                 + 
                 55 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAAATATGAATATATTTAAATA 
                 1100 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGTTATCAGTGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 11 
                 10 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCCACTGTGCGACGAGCTGTGC 
                 1101 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGCACGGTGATCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 11 
                 10 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCGAGACGATGAAGGAGAAGA 
                 1102 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGACAGCGGCTGCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 11 
                 10 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGCTGTCTGCCTTCTGCATCCA 
                 1103 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGCTACCACAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 11 
                 10 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCAGCTGAGGAGATGGGTGGCT 
                 1104 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTGGGCAAACTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 11 
                 10 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGACCTTCCGGAGGCCCGCCCA 
                 1105 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCCTTCCCGGTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 11 
                 10 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGAGGGCCGGCGGGCACCGGA 
                 1106 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAGGAGTAGCTGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 11 
                 10 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGACTCCATGGAGAACCAGGTC 
                 1107 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCGTGGATGCCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 11 
                 10 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCTGCCCCGCAGGGACCCTCAC 
                 1108 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGGATCTTGAAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 15 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATAACCTCTTTCTAGAGAAGGCT 
                 1109 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGCAGCTTGCAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 15 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCGCGTAGTCGAAAAGGGCATT 
                 1110 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCATGCCTCTTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 15 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACAGGAGACGTGAAGATGCTGC 
                 1111 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGCCGTCCAGCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 15 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCCCCATTCTCATCCTGCACAGC 
                 1112 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTGAGATGGCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 15 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGTAAGTCAGAACTTTTGCATG 
                 1113 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATAGGTTGTCCTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 16 
                 15 
                 − 
                 −34 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGCTCTGCTGATCCTCTTTTTCT 
                 1114 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTGTCTAGGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 16 
                 15 
                 − 
                 1 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCTGAATGCTCCGAAGTCCTGA 
                 1115 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTCTTGATGGTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 16 
                 15 
                 − 
                 36 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGAGCCTTTGCCAAGAACCCCC 
                 1116 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTTGCGTTATAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 16 
                 15 
                 − 
                 71 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGCCCCCAATCCCTGCAGCCCA 
                 1117 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTCTACTCACAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 9 
                 4 
                 + 
                 −18 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTTTCCCCTGTGAACAGAAGCC 
                 1118 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCAATGCATCCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 9 
                 4 
                 + 
                 17 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGCTGTCCTGTCCATTCTTACA 
                 1119 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTTTCAAGTTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 9 
                 4 
                 + 
                 52 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGTGTGACTGGAGGGGAGGAA 
                 1120 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTTATCTTCTTTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 9 
                 4 
                 + 
                 87 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCACAGAATGTATTTACCTTTCTG 
                 1121 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACTTTGTCACACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 13 
                 12 
                 − 
                 −2 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGACAGGATCAGTGCTTCCTCCC 
                 1122 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCGGGTGGTGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 13 
                 12 
                 − 
                 33 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATGTCCGCGCACAGAGCTCTGG 
                 1123 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACGAGCATCTCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 13 
                 12 
                 − 
                 68 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAACGCTGCAGCTACTATGAGAC 
                 1124 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGTGCAACCTAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 13 
                 12 
                 − 
                 103 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACCCTCCTGGAAGACCCGATCC 
                 1125 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACATTGAGCCCAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGGAGGAAGTGAGTATCATGGA 
                 1126 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAAAAAAATACACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCATCACATTGCACACTTGGTAG 
                 1127 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTCGGATTGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACCCAGCCAGAATAACTGGCTA 
                 1128 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGAACTGATTGGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCAATATACACCCTCTGAGCCCC 
                 1129 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCTCGGGTGATACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATTAAATTCACCTTGAGGGACT 
                 1130 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAATAGTCTTCACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTAAACGTCTCCTTGCAAGTCC 
                 1131 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCATGACGCCCGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGTACTACTATGAATCAGACAA 
                 1132 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGACAAAGAGCGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTCAATTTTGACAAACTGGTTCT 
                 1133 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTGATGAAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCATTGCTGCTGATGAGAGCTTC 
                 1134 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCCAAGTGGACACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCTCGGTGTTCAGCTTCATGATT 
                 1135 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGTCACCAATACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGGGATGTAGGGCCATTAAGCA 
                 1136 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAGGGGTTTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCGATGCAGGCCCCCACATCCT 
                 1137 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAAAGCCAGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGTATCAGTCCGTGTGTTCTAT 
                 1138 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAAGTGTCCACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTCAGGAAACTGGGCCAGATTG 
                 1139 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGACTGTGAGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 490 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCATCACAGGGGCTGATACGTCT 
                 1140 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCCTGGTGGAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 525 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCTCTTCTGAGTTGTTGACACAG 
                 1141 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGCCTCGAACACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 560 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGATGTGCCAAAAATGTACTGTG 
                 1142 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGCAGATGGTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 595 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTGCATAGGCAGTTGCCAATGG 
                 1143 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTACCAGCCATTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 16 
                 2 
                 − 
                 630 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGGGCATGAGGAGCGGAGCG 
                 1144 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGAATGCCAAGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 12 
                 12 
                 − 
                 −15 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCAACTCCCCTCAGTGGCCCAG 
                 1145 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGGTGGTGACCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 12 
                 12 
                 − 
                 20 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGCAGGCAGCCAGAAGCTGTTG 
                 1146 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGCTTGCGCAAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 12 
                 12 
                 − 
                 55 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCCCTGCCCAGCTCCCCAAGCC 
                 1147 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTCAGCTGCATACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 12 
                 12 
                 − 
                 90 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAACCCCAACTCACCTGGCCAG 
                 1148 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTACCGGAGTGGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 16 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTGATGTGTGAGAAGCGGATAT 
                 1149 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGCGGCAGTGAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 16 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAGAGGTTCACCAGGAAGGGG 
                 1150 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTCCCGCACTGGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 16 
                 19 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCTGTTTCCAGACACCGGAGCA 
                 1151 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGTGTGCTTCGTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 16 
                 19 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGCATCAGGTCCCCACCGGCC 
                 1152 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGTACTCCATCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 16 
                 19 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACATCCACAGCGACGTGTTCTCT 
                 1153 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGCCCCGTGCCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 16 
                 19 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGGCAGGGGCCCGGGCTGGGG 
                 1154 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCAGGCTCACATACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 8 
                 X 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTAAAACTTTTAATAAAGGGAA 
                 1155 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAGACCAATATACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 8 
                 X 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATATTGCTCCAACATCCGAAGC 
                 1156 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATAGAATCAATAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 8 
                 X 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTAGCAACTTGGAAGATTTGATT 
                 1157 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGGAGCGGACTACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 8 
                 X 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTTCCGTTTTCTGTTTTTCAATTT 
                 1158 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAGCTCTTCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 8 
                 X 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTTCTAACACAGATGCTACCAC 
                 1159 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGTATGTGAGAAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 19 
                 10 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACTACTTGGACCTTGCGGCGTC 
                 1160 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACTCCATCTGAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 19 
                 10 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCCTCTGAGAGGCCGTCGTCA 
                 1161 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAAATCAGGGAGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 19 
                 10 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGACACCGCTGGTGGACTGTAAT 
                 1162 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATGCCCCCCTCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 19 
                 10 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGTTTTCAATCCATGTGGAAGG 
                 1163 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGGGCTCGAGGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 19 
                 10 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTCTATGGTAGAATTTCCCATG 
                 1164 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATTTACTAGATACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 19 
                 10 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGAAGGATAGTGCAAAGGGGA 
                 1165 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGCGGTGCTAGAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 12 
                 13 
                 + 
                 −26 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATTTTCCTATTTTTATCCCCTCT 
                 1166 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGACTGTTATACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 12 
                 13 
                 + 
                 9 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATTTAAAATCATCATTAATTGTT 
                 1167 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGATAGTGTTCACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 12 
                 13 
                 + 
                 44 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCAAGTGATCAACCTTCAGAA 
                 1168 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATCTGATTTCCACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 12 
                 13 
                 + 
                 79 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAAATAATGTTTCATATATGGCTT 
                 1169 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACGTTAAAATAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 14 
                 X 
                 − 
                 −4 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACAGAGAGGAAGTCGTGCCAGTG 
                 1170 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAAGCTTCCAGAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 14 
                 X 
                 − 
                 31 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTTGGGGACCTCCCACTTTGGA 
                 1171 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTCTGAGGTAAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 14 
                 X 
                 − 
                 66 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCTCCTTTTCTTCAGGGAGTCTA 
                 1172 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTCCAGCTACACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 14 
                 X 
                 − 
                 101 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTACCTCATAAATCGCTATGTTGG 
                 1173 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTTTTCATAGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020975 
                 20 
                 10 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCATGTCAGACCCGAACTGGCCT 
                 1174 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAGAGAGTCCTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020975 
                 20 
                 10 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGTGTTAGTGCCATCAGCTCT 
                 1175 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGTGAGTGGTACACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020975 
                 20 
                 10 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTTCCAAGATATCCAAATGATA 
                 1176 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGTATATGCTAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020975 
                 20 
                 10 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATTAATTTTGCCGCTGAGGGTG 
                 1177 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAGCATCCAGTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020975 
                 20 
                 10 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACACGTTTGATAGTTAACATTT 
                 1178 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTTGTGAAAGGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 6 
                 19 
                 + 
                 −40 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGCAAAGAGTCGGCTGAAATGT 
                 1179 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATTTGCTGTCTACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 6 
                 19 
                 + 
                 −5 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCTTTTTCCTTTTTTCCTCAAGTT 
                 1180 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGCCCTGTGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 6 
                 19 
                 + 
                 30 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGAAGAGAAACGGTTAAGAGAA 
                 1181 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAGAGAAGGTAGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 6 
                 19 
                 + 
                 65 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACGGGCTGGGACGGGGAAGCTCT 
                 1182 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGGAAACACTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 14 
                 12 
                 − 
                 −28 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGAACATTTTCTGTCTCTTTTCC 
                 1183 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAGGTTTTCCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 14 
                 12 
                 − 
                 7 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGACTGTGCACGTCTGAGACAT 
                 1184 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAGTACTTGGTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 14 
                 12 
                 − 
                 42 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGGAAAGGGATGCTTTTTGGCC 
                 1185 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAAGTGTAAAAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 14 
                 12 
                 − 
                 77 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAGTCACTGCAGGGCACAGTCA 
                 1186 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTACTTGCAGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 9 
                 6 
                 − 
                 −42 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGTAAAATGACTGAGATTGTCA 
                 1187 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAATTTGCTTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 9 
                 6 
                 − 
                 −7 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGGTCAGCTTTGCTATAACCAC 
                 1188 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTGCCTTGAAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 9 
                 6 
                 − 
                 28 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAGGCGATGAAGAGCTTTACTT 
                 1189 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCATTGTAAGTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 9 
                 6 
                 − 
                 63 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTAATAGGGGTACATCATAATAA 
                 1190 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAAAAGCCAAAACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 10 
                 1 
                 + 
                 −34 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATCAGAGCCTGAATAGATCCTT 
                 1191 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCCTCTGCAGTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 10 
                 1 
                 + 
                 1 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCCTGGAAGGGCAGGGAGCCCG 
                 1192 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAGCATCTCAAACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 10 
                 1 
                 + 
                 36 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGGACCGGAAGGAGACCATGA 
                 1193 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACTGATTCTGAAACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 10 
                 1 
                 + 
                 71 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGTCCATTGTTATCAGGGCAGG 
                 1194 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTGGGGCTTACACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 5 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACCTCCATCTTCACCAAGAAAT 
                 1195 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTATCTCTAATACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 5 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAACTCCAGTCCAGGATAACTGA 
                 1196 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTCTCGTTTATACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 5 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCCCTGGACACAGGAGGCCGGA 
                 1197 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGATGTTACCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 5 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATATTCCACCCACATTTTTTACA 
                 1198 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATGATGTTGAACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 5 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAACAGTGTGAGCCATGCAGCCC 
                 1199 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAATGTCCGCTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 5 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGTGGTGTTGGTGAGTCCAAAC 
                 1200 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTCGAGGGAGGACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 5 
                 3 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGACAGTGACAGACCTTCTGGCA 
                 1201 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATACTAACTACACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 5 
                 3 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTGACACCCCATTAACGGCATC 
                 1202 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATCTCAAAGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 5 
                 3 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGAGCTCCCCACCAAGACAGT 
                 1203 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGCTGCGGTCAACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 5 
                 3 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGTATGTACTCACCAGCCTGAT 
                 1204 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGTTGTGATGCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 10 
                 10 
                 + 
                 −10 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGCCCTCAGGGGGCAGCATTGT 
                 1205 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGGGGACACGAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 10 
                 10 
                 + 
                 25 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATAGCCAGCTTTAATCCCCCGG 
                 1206 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCTCCCCAGGCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 10 
                 10 
                 + 
                 60 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCACCTGCAACTGCTTCCCTGAG 
                 1207 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGGAGAAGTGCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 10 
                 10 
                 + 
                 95 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCCACTCACCCTGGATGTCTTC 
                 1208 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGCTCGCAGAAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 13 
                 4 
                 + 
                 −25 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCATTTGTTTTACTTGCCGTTTCA 
                 1209 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGTATAGCTTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 13 
                 4 
                 + 
                 10 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAATCCCACCATAAGTAGGAAAT 
                 1210 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCATAGTGTGGGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 13 
                 4 
                 + 
                 45 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTTCCATCCTGGAACTACTAAAT 
                 1211 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTAATGCTGGGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 13 
                 4 
                 + 
                 80 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTATTAAGAACAAAGCATTACTT 
                 1212 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCATGCTTCATACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 18 
                 13 
                 + 
                 −10 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTCATATAGGATTCACCTTTATT 
                 1213 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGATCTTATTAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 18 
                 13 
                 + 
                 25 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGATCAGTTGGTCCTTCTCGGTC 
                 1214 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTTGATTGTTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 18 
                 13 
                 + 
                 60 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTGAATCTGCTTGTCCTCTTAAT 
                 1215 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTCCTCTCCAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 18 
                 13 
                 + 
                 95 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTTGCTTACATATCTGCTGCAG 
                 1216 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTGATTATTCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 5 
                 X 
                 − 
                 −20 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACCCCCTGATACTCTATAGGGC 
                 1217 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGTTGTTGCTGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 5 
                 X 
                 − 
                 15 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAGCAGTATCTGGGCATGGTGA 
                 1218 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCCCACCACTCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 5 
                 X 
                 − 
                 50 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTGGAGACACTGTGAACACAGC 
                 1219 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCTCGGATGGAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 5 
                 X 
                 − 
                 85 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCTCTCTATTAGGTACTCACGTA 
                 1220 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCCTGTAGATACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 5 
                 6 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAACATGATGGGCAATTTACAGT 
                 1221 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATTCAGTTAGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 5 
                 6 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCTCATTCCAGCAGCAATTCCTC 
                 1222 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAGCATTCCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 5 
                 6 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTGGCTGATATGGGATATGTT 
                 1223 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACAGGGACCTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 5 
                 6 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACGAGATTGCTGTTGACAAGAAT 
                 1224 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTGCGAGCTGCACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 5 
                 6 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGTAAAGTGTCAGATTTTGGCCT 
                 1225 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCCCGAGTTAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 5 
                 6 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTAGTTGTATAGACAGCTTCTG 
                 1226 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATCATCCTCTAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 5 
                 6 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTAAGAAAAAGTCATTTACTGCA 
                 1227 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTCTTCATATTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 24 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACGAGCTCCGAGACAGTGACAGT 
                 1228 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCTGCGACAGCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 24 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTAAAGCTGAGTTTGCGGAAGGA 
                 1229 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTCTCCACGCCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 24 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGAGTCTCTGACCAGTGGTGCCT 
                 1230 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACTGCTAACTCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 24 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCTTCCTGCCCATAATCATGGG 
                 1231 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCATTTTGTTGAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 24 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCTAGAAGGCAAAATTTAGCC 
                 1232 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCTGACAATTTACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_203292 
                 18 
                 18 
                 + 
                 −18 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTATGATTTGTTTTTAAGGTTATA 
                 1233 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTAAGGAAGATACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_203292 
                 18 
                 18 
                 + 
                 17 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCTGACGTCTTTTTGGACGAGG 
                 1234 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAAGGATCAAGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_203292 
                 18 
                 18 
                 + 
                 52 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTACAACGCAATATTTTCTCCAA 
                 1235 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGGCAAGGAGCACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_203292 
                 18 
                 18 
                 + 
                 87 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCCTTCTGTTTCTGTTTCAACGT 
                 1236 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTATGTCTTCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 2 
                 2 
                 − 
                 −12 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCTATGTACAGGGACCTGGCAA 
                 1237 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAATTGGTATCAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 2 
                 2 
                 − 
                 23 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTGCTCAAAATCTTATTCTGGTG 
                 1238 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGTGATGGCTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 2 
                 2 
                 − 
                 58 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCCAGGCAATGCGAACCCAAAT 
                 1239 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAGCAGATGCAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 2 
                 2 
                 − 
                 93 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTCAGTACTGGCTCAGACGGGA 
                 1240 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCATTCTGCCGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 6 
                 1 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTACGTGACCGCGTCCGGACCAAG 
                 1241 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGGAGAGAGACACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 6 
                 1 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCACCACGAATGGGTGATTTAC 
                 1242 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCAGCCAGGATACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 6 
                 1 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGCACTATGGTAAAGCTTCTG 
                 1243 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCCTGCCTGAGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 6 
                 1 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCACAGGCAAGGGCGAAGGATG 
                 1244 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTGGGGTAGGAGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 6 
                 1 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTGTACACTGTCCCACCGCCTGC 
                 1245 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGGCAGGCCAACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 6 
                 1 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCCTTATGATCTGCTTCTCCGGC 
                 1246 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTGGCTCCCTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 6 
                 1 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGCCGACTCTACCATTGCCTTTC 
                 1247 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCCTCTTCCCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 6 
                 1 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAATGAGATAGAGCTTGCCCTCG 
                 1248 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCTGGAAGGCTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 6 
                 1 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGACTTCCTGCGTGGTGGGGAC 
                 1249 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTTCACCCGGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 6 
                 1 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTGGCAGTAGATGTCAGCTCAC 
                 1250 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTTTTGAGAGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001007156 
                 1 
                 15 
                 − 
                 −6 
                 + 
                 2 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTATAGGTTTCAGAGAAATTATG 
                 1251 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGAATCCAATAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001007156 
                 1 
                 15 
                 − 
                 25 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTTAAGAGGCTTGGAATGTCCG 
                 1252 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAAGGCTTATTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001007156 
                 1 
                 15 
                 − 
                 60 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGGCATCTATGTTGAGGATGTC 
                 1253 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATGTTTATTTCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001007156 
                 1 
                 15 
                 − 
                 95 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAAGGAGTTTTTAAAAGCCATG 
                 1254 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACGTCCTTTGCTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 9 
                 10 
                 + 
                 −14 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTGTCCTGTGCAGGGATCACCA 
                 1255 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAACTTCTCCAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 9 
                 10 
                 + 
                 21 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCGTCGGGGCAGGTCTTGGTGC 
                 1256 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGGAGAGCAGGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 9 
                 10 
                 + 
                 56 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACTGCGATGTTGTGGAGACCCA 
                 1257 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGACATCAACATACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 9 
                 10 
                 + 
                 91 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTAAACCCTGCTTACGGAGGCAG 
                 1258 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCTGAGGGCAAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 3 
                 15 
                 − 
                 −49 
                 + 
                 35 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTCTAAGTTTTCTTCTAATATTA 
                 1259 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTATTGTTTTGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 3 
                 15 
                 − 
                 −14 
                 − 
                 35 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTCCAGATGGATTAAAGAGCT 
                 1260 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAACATAAAAAAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 3 
                 15 
                 − 
                 21 
                 + 
                 35 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATTTTTGTATATGGTGTGAGGT 
                 1261 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGTATCTAAGCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 3 
                 15 
                 − 
                 60 
                 − 
                 32 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAGTGTTGGGACAATGAACTAT 
                 1262 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCATTAAAAAAAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 9 
                 3 
                 + 
                 −38 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCCCTGTGGCTGAGAGAGCCCC 
                 1263 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTTTTTATCCAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 9 
                 3 
                 + 
                 −3 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTACACAGCCTCTTTGCTATAA 
                 1264 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCCGTTTCCTGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 9 
                 3 
                 + 
                 32 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGATAAGCTCCAGCATTACAGC 
                 1265 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAGGCCGAGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 9 
                 3 
                 + 
                 67 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGGGGGTCAGACACCGGGTCTC 
                 1266 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCTTTCTACTTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 12 
                 3 
                 + 
                 0 
                 + 
                 0 
                 0 
                 2 
                 0 
                 CGCGAATGCCATGTATTGCTTGGTAAAAGATTG 
                 1267 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCTCCAATCAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 12 
                 3 
                 + 
                 35 
                 − 
                 0 
                 0 
                 2 
                 0 
                 CGCGAATGCCAATTACAGTCCAGAAGTTCCATA 
                 1268 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCTGTTCAGGTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 12 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCCAGATCCTATGGTTCGAGGT 
                 1269 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTGCTGTTCGGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 12 
                 3 
                 + 
                 103 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGTTTGTCATCTGTTAAATATTT 
                 1270 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCCAAGCACCACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 12 
                 3 
                 + 
                 136 
                 + 
                 5 
                 0 
                 2 
                 0 
                 CGCGAATGCCTTTCTCAGTATTTAATTCAGCTAG 
                 1271 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACAGGTAAAAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 5 
                 16 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCATTGTTTTGTTCCTCTGATGA 
                 1272 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAAAGTGAAAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 5 
                 16 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCTTTTATATTTCCAGACTTCAG 
                 1273 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGTACTTGCTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 5 
                 16 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGCTTGGCCTGACAAAGAGGAG 
                 1274 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTAGTTAGTAGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 5 
                 16 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGACTTCTACTTGTTGATCAGAA 
                 1275 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGGTCCCACTGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 5 
                 16 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGACGTTTGCAGAAGATGGAGGG 
                 1276 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAAGAAAAGCATACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 18 
                 1 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTGTGCACAGGGACCTGAAGCC 
                 1277 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGCAACATCCTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 18 
                 1 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGGCACTCGGGATTCCCGGAC 
                 1278 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCGTCCACATACACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 18 
                 1 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCATCTGTGACTTTGGTTTTGCCA 
                 1279 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACAGCTGCGGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 18 
                 1 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGTAGCAAGGTGTCATGAGGAG 
                 1280 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCATTCTCAGCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 18 
                 1 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCCAACTTTGTGGCGCCTGAGG 
                 1281 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAGTGGCCCAGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 17 
                 4 
                 + 
                 −12 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTTTTCTGCAGACTCAGAAGTC 
                 1282 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAACCTCCTTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 17 
                 4 
                 + 
                 23 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCAATAAAGTAAGGCCTTCTGA 
                 1283 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTATCATCTGAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 17 
                 4 
                 + 
                 58 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTGTTGAGCTTCACCTATCAAGT 
                 1284 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCCCGAGGAAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 17 
                 4 
                 + 
                 93 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTTGAACTTACATTTTTTGAAGC 
                 1285 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAAAACTCCAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACCTAAAAATAAAATATGTGTT 
                 1286 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATGACAAGTTAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCCAGTTTCTTCATCAAGATGG 
                 1287 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTTTGATGTGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAGACATCTATCACACTTGATG 
                 1288 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGGGCCTGAGTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGTAATCCTCCTGGGCCATCTC 
                 1289 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGGGTTAAAGGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATACAAAGAACAGATGACACCCA 
                 1290 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAACATTTTCCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTTTTGCTCACCACTAGGGTCA 
                 1291 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGACCCTGTGGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGAAGCTGCCAAGCAGAAGAAA 
                 1292 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAGCAGCAGAAGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGACACAGTCTCTCTCCTGTGA 
                 1293 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATAAATGTCCTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCACTGATTCACTCAGATTGT 
                 1294 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGGGAAAAGACACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGATTTTTGCTACTGATTTCTTC 
                 1295 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGTTCCTTTAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTAGATCACCAGTAACTGAAAT 
                 1296 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGAACTCACCTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGAGAATCTGGAAGTTCAGAT 
                 1297 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTAAGACTTAAAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACCAGTTACAGAAATTAATGAA 
                 1298 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACAGTGTATTAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCAACACCTTTTTCTGGTTGGGCA 
                 1299 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTGGTGGAATACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 490 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTACATTCCTAAGAAGACCTAATT 
                 1300 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCACCAGGGCGAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 525 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCGCTATCTGATAGAGTCTGTA 
                 1301 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGGAACTGTAGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 559 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGTAGTCAGCACCTTGAACACA 
                 1302 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCCTCCTAAAGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 595 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTTTTTTAGGTCGTGAGTAGTAA 
                 1303 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTCACTGCTAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 630 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTAGATTTACTTCACCTGTAAGTT 
                 1304 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGAGGCACAAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 665 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGAGGTTATCTGTAGAGACAGT 
                 1305 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATTTTTTTGCCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 700 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTAAATAAAGCTATAAGTAAAA 
                 1306 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGCCAACTGCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 735 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACATGAAATATTTGCCTCTAAAT 
                 1307 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGAACTTGTGGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 770 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCTAAATGAACTCACCTACAA 
                 1308 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAACTTACCAGCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 805 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTGATTTTGTTCTTTTAAGTTTTG 
                 1309 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTTTCATTTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 840 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGAGAAATCTTTAAAATCTCCC 
                 1310 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTGACACTCTTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 875 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCTCACTTTCCTGAAGATTTTCA 
                 1311 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCCTGCCATCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 910 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTAAGTCAACCTAAGAGTCTTA 
                 1312 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCTGGAAGCAAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 945 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTGCAAGAATGTTTTTCTGCAG 
                 1313 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAGAGGAGAGGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 980 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGCCTGAAGGCCTTCTGTTTCCT 
                 1314 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAGAATATTAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 1015 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTGGCAATTGGACATGCTTCGT 
                 1315 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTGTTCTAACAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 1050 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAAAGTAGCCGTGGAGGCTGTC 
                 1316 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTCAGAGTCATACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 1085 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTTTATTTTTAAACCCTTTTTTCT 
                 1317 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGACATCCAAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 1120 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAAGGATGCAAGTAAAAATTTAA 
                 1318 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCTTTCCAATGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 1155 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCAGACATCCTAATTTCACTTTG 
                 1319 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCAGTTTCCTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 1190 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACATGCACAGGACAACCAAGTTC 
                 1320 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGAACCTCTCAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 1225 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGGAGAGCTGACTTTAGTTAAT 
                 1321 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGAGAAGTTTCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 1260 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGGCCCACTGAAGATAATGAC 
                 1322 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGTCTAGGAAGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 1295 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTGTGTATCTTCTACCAGGTGCT 
                 1323 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGGCAACTGCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 1330 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAAAGAAAATCAGCCTGCACCC 
                 1324 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGCATCAGATCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 1365 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGACAGGCTAGAAGTTGGCAAAA 
                 1325 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGTTCACAATACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 1400 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTGTTAACAGGTCCAAGGAAGA 
                 1326 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTCACCTCACAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 1435 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCACTTGAATAAATAATTTTTCGT 
                 1327 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTGATATTTGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 10 
                 16 
                 − 
                 1466 
                 + 
                 11 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGAAAGGTAAATCAAGATGTGT 
                 1328 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGATGATGATGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 8 
                 13 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAACAGCTGTTATACCCATTAAT 
                 1329 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTTCACCTCGAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 8 
                 13 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCCGTGCACTCCTGTTCTGACCT 
                 1330 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGCCTGGGTGTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 8 
                 13 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCAAAACAACTAGAAAATGAT 
                 1331 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAAGAATTATTGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 8 
                 13 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCTATATTACATTCATGTTCTTT 
                 1332 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAGAGAACTTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 8 
                 13 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGGTAATTTAACTTCATGATTTC 
                 1333 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTAAAACAGTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 16 
                 1 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAACTCCATGGGAAGAACCTGGT 
                 1334 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTTAGTGACGGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 16 
                 1 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGAGCCCACACCAATTGTCTCC 
                 1335 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTACCACGTAGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 16 
                 1 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTCTGAGTGCAAGCGCTGTGTC 
                 1336 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACAAGGCCACCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 16 
                 1 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCAGGAGGCCCACCTTGACAGC 
                 1337 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATACTCCATGTTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 16 
                 1 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACGTCTCGGCCAAGGCTGCTGG 
                 1338 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTGGGGGCAGGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 16 
                 1 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGCTCAGGCACCATCCCTCCCC 
                 1339 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCAGACGGGGAACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 16 
                 1 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCAGATGTATGAAAGGTGTGTG 
                 1340 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCGAGACCTCCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 16 
                 1 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGTCCAGGGTCCTTTCTGGCCA 
                 1341 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGAGCAGGCCAACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 16 
                 1 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTCACCCTGACACTGCCACATG 
                 1342 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACCCCCTTTCTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 16 
                 1 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGAAGGATCCCGCTTGCTCTTAT 
                 1343 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAATGACCTGAACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 16 
                 1 
                 + 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGAGATTGAGATTCTTCTGCGG 
                 1344 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATGGCCAGCACACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 16 
                 1 
                 + 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCCCACTCACATCTTTCAGAGT 
                 1345 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATGATGTTGGGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 1 
                 3 
                 + 
                 −41 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGCCTCGGCTTGGTCTCGGCCTG 
                 1346 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGGCCGTCGGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 1 
                 3 
                 + 
                 −6 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGAGCAGTAGTAGATAATCCAG 
                 1347 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCCATCGCCGGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 1 
                 3 
                 + 
                 29 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTGGCATCCGCAGTGGCTGCGA 
                 1348 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGAAGGTAACGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 1 
                 3 
                 + 
                 64 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGGCACCAGCAGCCAACTTGCT 
                 1349 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGTGGAGGGTAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 1 
                 16 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTCCTGGAAGGTGACGTGAAAG 
                 1350 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCACTGTGCAGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 1 
                 16 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAAATGGCAATTGTTCCAGAAG 
                 1351 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAAGATTGCTGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 1 
                 16 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACTTACTTCTCGGTCAGTGTACT 
                 1352 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCCTCCTCCCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 1 
                 16 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTCACAAAAGACCAATGTTGG 
                 1353 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAGAGACAGGTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 1 
                 16 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTCGGGTACAGACTCTCATTTG 
                 1354 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGGCTGGACAAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 1 
                 16 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATGAATAGTGGTATACAAATAT 
                 1355 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTTCCATCTTTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 1 
                 16 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTTAGGGTAAAGTGAAAACACA 
                 1356 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTTTCTGGATAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 6 
                 12 
                 − 
                 −6 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTAAGACTGTACCCCATCTGGA 
                 1357 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACCTGAGCCCCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 6 
                 12 
                 − 
                 29 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCACCATGGGAGAAGGAGGGG 
                 1358 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTCCCGACTCAGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 6 
                 12 
                 − 
                 64 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAGCAGAGGAGGAAAAAATTG 
                 1359 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAACACCATCCAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 6 
                 12 
                 − 
                 99 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCACCTTCAGCCTGCCCAGCCG 
                 1360 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCCTTCAGTCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 11 
                 6 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATCAAAGGGAACGGACCTACTC 
                 1361 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACAGTAAAAACACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 11 
                 6 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTTCAGATTATTAATGGAGGCT 
                 1362 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAGTAGACTTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 11 
                 6 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGGAACAGTGTATGTTTTCCAG 
                 1363 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTCGGGCTTTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 11 
                 6 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTCTGGGACTGTAATTTCCATA 
                 1364 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCAGCAGCAGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 11 
                 6 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGATGTTGCTACACTAGAGGAAG 
                 1365 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTACAGGTAAAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 11 
                 6 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAATCCAAACCAAAGGCATAAT 
                 1366 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACCTTCAAACAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 5 
                 13 
                 + 
                 −50 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTCTAAATTACGAAAAAATGTT 
                 1367 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAAGTCATAAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 5 
                 13 
                 + 
                 −15 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATATATAAGTTCACATGTCCTG 
                 1368 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAGAAAAACAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 5 
                 13 
                 + 
                 20 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGACACAACCCAGCAGTTCGTAA 
                 1369 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTAGTTCACAGAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 5 
                 13 
                 + 
                 55 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATAAAAATCTTTTTTTTTAAGTG 
                 1370 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAATAACATACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 4 
                 2 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGATTAAAGCCATTGAGGAAGG 
                 1371 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTATCGGTTACCACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 4 
                 2 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGGTGGAGCGCAATGGGGCAG 
                 1372 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCATTGGAGGGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 4 
                 2 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGATGCTAGACTGCTGGCAGAAG 
                 1373 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGAGGAGCGACACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 4 
                 2 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCAACATGTTGACAATCTGCCC 
                 1374 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAATTTAGGCCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 4 
                 2 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAACTCATCCGCAACCCCAACA 
                 1375 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTTGAAGAGGAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 4 
                 2 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTAAGCATGGCTGACCTGGAGC 
                 1376 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTCCGTCCCTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 1 
                 6 
                 − 
                 −12 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTCTTTTTCAGGGATGTGATGA 
                 1377 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTTAGGGATCAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 1 
                 6 
                 − 
                 23 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGCTCATGATTTTCTTTTGATG 
                 1378 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCAACCAGTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 1 
                 6 
                 − 
                 58 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTCAGACTATGAGAGCACAAAT 
                 1379 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTACATTTACAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 1 
                 6 
                 − 
                 93 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGAAATGCATATCACACTTGA 
                 1380 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGCCAGTTCCAACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 11 
                 1 
                 + 
                 −26 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGATGAGTCCCGGGGGCTGTTT 
                 1381 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGGGCGAAGCTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 11 
                 1 
                 + 
                 9 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTGGGCTTCAGTGCTCAGAAAC 
                 1382 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGGGCATGCCTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 11 
                 1 
                 + 
                 44 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCTCTTGCGGGCCCTGTTCAAG 
                 1383 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGAATCCTGCCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 11 
                 1 
                 + 
                 79 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCCCCTGAGCTGGGGCTGCTT 
                 1384 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCGAGCCGGTTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 2 
                 3 
                 + 
                 −38 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGTTTTTGTTTATTCGTTTTTTCT 
                 1385 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTTAATCTAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 2 
                 3 
                 + 
                 −3 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCAGTAGCCGTTCTGGTGTCCA 
                 1386 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTAACGTTTCTGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 2 
                 3 
                 + 
                 32 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGCTGGGCTGGACGGCCAATCC 
                 1387 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCGTCCGGGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 2 
                 3 
                 + 
                 67 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATAGCAGGACTGAAAGACGAAT 
                 1388 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTTTGATACTCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 19 
                 4 
                 + 
                 −14 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCCTTCCTTGCAGACCTTTCTGC 
                 1389 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGTGAAGTGGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 19 
                 4 
                 + 
                 21 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGTAGAGGTTGTCAAAGATGCT 
                 1390 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCAGGAGCCATACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 19 
                 4 
                 + 
                 56 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACACTGAGTGATGTCTGGTCTT 
                 1391 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGGCATTCTGCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 19 
                 4 
                 + 
                 91 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTCAGGCCCATACCAAGGGAAA 
                 1392 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGATCTCCCAGAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGAAAACTTTGAGTTCCTGATC 
                 1393 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGTCCAGCACGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCAAAACTGGCTGCCTCAAAGTG 
                 1394 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCACGTCTGACCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGCGGGATGCCTGGGTCCAGG 
                 1395 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCATCGAGAGTCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGCTCTCACAGCATTGCAGAC 
                 1396 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGCTAGGATCTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGGTCAAGGTAAGAGTTTGAGG 
                 1397 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGAGTGGAGGAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCCGTCAGCACCAGGGTCAGT 
                 1398 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCTGCGGCCAGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGGCAACGACACGGCCGAAGTC 
                 1399 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGTGAGAGGAGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCCAAGCCCCACCTCCTTCTCAG 
                 1400 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACACCTCTGCTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGAGTCAGTGCCAACCCAAAC 
                 1401 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTCTCTGCAGCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATGGCCACGGCCTCGCTTTGGC 
                 1402 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTCTGTGCGCAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGGCGATCCGGAACGCCAAGG 
                 1403 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAATTCAATCTGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCCTGGCACTCACTGGGGGCC 
                 1404 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGCAGTCCACGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCGGAGGGGCTAGGGAGTGT 
                 1405 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTGAATGCCGGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTAGAGGTCGGCTCCCAGCCGGG 
                 1406 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGCACAGGCACACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 490 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTCCTTCCGCAGACCCCACGTG 
                 1407 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCCAGCTTGAAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 525 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCCAGAACACTCGATGCAGATG 
                 1408 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGGCGCCCAGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 560 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCACCGCAACCTGGGCACACAC 
                 1409 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGTCCCGCGTTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 595 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCTCCCGTGGCCAGTCGTCCAA 
                 1410 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCCAGCGAGCGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 633 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTGGTGCTGACGGCTATTGGCA 
                 1411 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACGACACGGCCAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 665 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACGGCCTCGCGTGTCGCTTTCCC 
                 1412 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACACGCGGTTGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 700 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCAAGCCCTCGCGGGACTCTTC 
                 1413 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCGGTAAGCGTGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 735 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACACCCTCAGCAACCCTCCCCCC 
                 1414 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTCTGTTCCCTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 770 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGAACCTGAGACGGTCCCGTGG 
                 1415 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTAGGGGCAGAAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 805 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAACGGAAAAGGCTCTAGGGACC 
                 1416 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCAGCCAGGACACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 840 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCCCTGGTCTTGCAGGGAGGAG 
                 1417 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGCGAGTCGTGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 875 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCAGGAACAGTAGCTGCTCGTA 
                 1418 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTGGCGCGAATACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 910 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCGCTGAGCACCTCGGAGGAGC 
                 1419 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGCTGGGCCGCCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 945 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCCACGTCCTGGGCCTGCACGG 
                 1420 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGCCCACAGCTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 980 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCGTTCTCCTGCTTTTGGCCCAT 
                 1421 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCGCGACACGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 1015 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGCTGTGGGTCCTCTACGCTG 
                 1422 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGTCGAGCGGCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 1050 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTCCCCACTCCACCTGGCGGCC 
                 1423 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGCTCGCCCACACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 1085 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCACGTACCCACAGCAGCAGTTG 
                 1424 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGTGATGACGACACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 1120 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGGGGGGAGGAAAGGGGGTC 
                 1425 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTGAGGCTTCATACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 1155 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATTTCGGGCTTTCCCGCGCCAG 
                 1426 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCGTTTTCCGAGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 1190 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCAGAGGGACCCCGGAAGTAG 
                 1427 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTTGGCCATGTGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 1225 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCCCCAGGGCGCCCACACCCGG 
                 1428 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGCCGCCTCCCCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 1260 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGCGGTCACGCGGCCGTTTCCG 
                 1429 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCTCTAGTACGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 1295 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGGCCCTGGGCGTCACGGGCCG 
                 1430 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCACGTCCGCGCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 1330 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACGGCGCTGTTCTACGCCCGCCA 
                 1431 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCTGGAAGCCAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 1365 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCAGCCGTGCTGGAGAAGGATG 
                 1432 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCGGCGCACAGCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 1400 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGGTGAGGGCGGCAGCGCGGC 
                 1433 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACCACGCCCAGCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 1435 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGGCGTGGCGGTGATGCTGGG 
                 1434 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGTGGTGGCCGCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 1470 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCCCGCCGCCGGAGCAGCGCCG 
                 1435 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTAGCGTGGGCCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 5 
                 12 
                 − 
                 1505 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGCAACTATACCAGCGCAACCG 
                 1436 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGCGTCGGCGCACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 13 
                 6 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCCTCCATCTGCACCACAGAAC 
                 1437 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCATTTTCAACACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 13 
                 6 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGACTCCATTCCAAACTTACTGT 
                 1438 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTTTGGTTGATACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 13 
                 6 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCTGCAGACAATGGGGGAAGAA 
                 1439 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACGATGTGACCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 13 
                 6 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGCTCCCAACTGCACCGCTTAC 
                 1440 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAATATTCTGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 13 
                 6 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCGAATGTGTTCCCTGTGGGAG 
                 1441 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAACATTGGATAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 13 
                 6 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATAGTTATCCTCTAATCCAGTCT 
                 1442 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTGGGGCATGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 13 
                 6 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCACTGTCATGGACCTGCTAGCC 
                 1443 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACGCTAATTATACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 13 
                 6 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCAGAAACTCCATTTACAGCTTC 
                 1444 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACTTCAAAAGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 13 
                 6 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTAAGCCGATCCCAGAGGCTCT 
                 1445 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGCTGCTGTCAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 13 
                 6 
                 − 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACACAAAACATACCTGCTTGAC 
                 1446 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGTGGTGATACACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 7 
                 19 
                 + 
                 −36 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCCTCTTTCTCATCACCATCTC 
                 1447 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTAACATCACAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 7 
                 19 
                 + 
                 −1 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCTCGTGATTTCGGCCTTCTCTG 
                 1448 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTTAATGCGCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 7 
                 19 
                 + 
                 34 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTTCCAGAAACCAAAGACTCCA 
                 1449 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGGCCCCCAAGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 7 
                 19 
                 + 
                 69 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGAAACCCAAAAGCAAAGGCA 
                 1450 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCGGCTGCTCACACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 6 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCCAGGAGAAATTAACAGAATC 
                 1451 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAACCAGAAGCTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 6 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAGTCTCCGCTCCAGAGCCTCC 
                 1452 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGCAGCAGCCCCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 6 
                 19 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGAGCTGCCCGCCGACCACCCC 
                 1453 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGGGGCGGCTGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 6 
                 19 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGCGGAGGAGGCCGCAGCGA 
                 1454 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTCTTCTCGCAGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 6 
                 19 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTCAGCACCCGCCTGGCCGGGC 
                 1455 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTTTCCCGCCAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 6 
                 19 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGCGGCGCGGGCTTGCACAGGG 
                 1456 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCTGTAGTGCGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 6 
                 19 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACAGGTGGGTCTGAGACCCTACC 
                 1457 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCACCCCTGCAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 2 
                 3 
                 + 
                 −38 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTTATTAACTGTGTTTGTGTATT 
                 1458 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGTTTTATTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 2 
                 3 
                 + 
                 −3 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCTTGAATTGTTTTTGAATCCAG 
                 1459 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGATTGACTAACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 2 
                 3 
                 + 
                 32 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGCTGGGCTGGATCTCTTATCC 
                 1460 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCACATGGGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 2 
                 3 
                 + 
                 67 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGAAAATGTTTCCTTGTGATAG 
                 1461 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTATTGAACTCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 5 
                 12 
                 − 
                 −3 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGGGCATGGGCTACCTCCACGC 
                 1462 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAGGGAATCCTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 5 
                 12 
                 − 
                 32 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATAGAAGACGTTCTTTGACTTG 
                 1463 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGTCCTTGTGTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 5 
                 12 
                 − 
                 67 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACAACGGCAAAGTGGTCATCACG 
                 1464 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACTTTGGACTCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 5 
                 12 
                 − 
                 102 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACCTGCCAGCCTGCAGCACCCC 
                 1465 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAAATGCTGAAACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 1 
                 1 
                 + 
                 −38 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCCGCCGGAGGAGCGCGGGTG 
                 1466 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCTGGCGGCGGCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 1 
                 1 
                 + 
                 −3 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCCAGGGCTCCTTGAGCTGGGC 
                 1467 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGCGGCATCTCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 1 
                 1 
                 + 
                 32 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTCATGGAGCTAGTGCCTCTGG 
                 1468 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCCGGAGGTGAACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 1 
                 1 
                 + 
                 63 
                 − 
                 27 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCGCGGGCGCCCGTCCCCCGCC 
                 1469 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGCTCACTCACACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 18 
                 12 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAATCTCCCCCGGCCAGCTGAG 
                 1470 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTGGAGGACCTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 18 
                 12 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGTCTCGCACACCTGTTCATCC 
                 1471 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCATCTCCAAGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 18 
                 12 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGAGAAATACGGAGCCAACCG 
                 1472 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAGGAGTGTGCCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 18 
                 12 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACATTCCTGAGGCAGGAGAGGGA 
                 1473 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCGTTGAGGCGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 18 
                 12 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCACATGTCAGGTGAGCAGGCCC 
                 1474 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGGGTCGGGGAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 10 
                 X 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCTGCTGTGGACGGCCCCTGAA 
                 1475 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGTTGAGAGCTACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 10 
                 X 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCCTGCAAAAGAACCTAACCT 
                 1476 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTGCCTCTTGGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 10 
                 X 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTCTATAGCTTTGCCATCATCAT 
                 1477 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAAGAAGTGAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 10 
                 X 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGATCCATCATGCAGAATGGGG 
                 1478 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACCCCGGACCAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 10 
                 X 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGCTCAAGGTAAGCGGGAGGT 
                 1479 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGAAAAGGGCCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 2 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTGAGCCTCGCAGCTGGTCCCT 
                 1480 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTAGAGCAGCTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 2 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCCGGGGGCCGCCAGGTCTGCC 
                 1481 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGGCCAGGCCCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 2 
                 19 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTACAGCAGCAGCTGGAGCTGGAG 
                 1482 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGGAGCGGCTGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 2 
                 19 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCTTCAGCTTCAGCTCCTTGCGG 
                 1483 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTTCCCGCCGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 2 
                 19 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGTGCTGAGAACCTGCGGCGGG 
                 1484 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCACCACTGACCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 2 
                 19 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCAGCAGCTCTACGGGGCCCA 
                 1485 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCTGCGGCCCAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 2 
                 19 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGGGCTCCTCGCGCCGCCTCGA 
                 1486 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTGCTGCACCAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 2 
                 19 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAGCACCACGTGGGCGTGCAGC 
                 1487 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCTGCAGCTGCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 2 
                 19 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGACCCGGCGGCCACCCACGGT 
                 1488 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGCTGGGATGCACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 7 
                 18 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAATGATCAACAGCATCAAGCAG 
                 1489 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGAGCTTGAATACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 7 
                 18 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTTATCGGTGAATCTGGAATAA 
                 1490 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGTCTTCCTCACACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 7 
                 18 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCTTCTCATTTTCTGGCGTTAAC 
                 1491 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGCTACGAAGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 7 
                 18 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTGTTCTATGTATCGGACATGGG 
                 1492 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTTCTCCTTTACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 7 
                 18 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACATACTAAATTGGAGCACTCT 
                 1493 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGTGTGCAAATACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 7 
                 18 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACCAGAGAACTAAAATACAACT 
                 1494 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAACTCTTACCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 13 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGGGAAGATCCCTGTGAGATG 
                 1495 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACAGCTCCAGAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 13 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCTGGCTGAAGTGAACTTGCGG 
                 1496 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGGCGATGGCCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 13 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACGTTTGGAGCTATGGGATCGTC 
                 1497 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGTGGGAAGTCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 13 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACATATCCCAATAGGGTCTCTC 
                 1498 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCAAATGACATACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 13 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAACCAAGATGTGAGTGTCAGCA 
                 1499 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCACTTGGTCACACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 12 
                 4 
                 + 
                 −4 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATAGAAACCGAGGTATGAAATTC 
                 1500 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTGGAGGGTCAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 12 
                 4 
                 + 
                 31 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATATATTCATGTCCATCTGGGCT 
                 1501 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATTGATTCAAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 12 
                 4 
                 + 
                 66 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATGTGGACCCGATGCAGCTGCC 
                 1502 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTATGACTCAAGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 12 
                 4 
                 + 
                 101 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTACCAAGCACTAGTCCATCTCTT 
                 1503 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAAACTCCCATACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 7 
                 10 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCGGGAAAGTCTGTGTGGAAAA 
                 1504 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGCCAGGCATTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 7 
                 10 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGAATGCAGCTTGTACTGGACG 
                 1505 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGATGCCACTGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 7 
                 10 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGTGCCAACTGCAGCACGCTA 
                 1506 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGGTGGTCACCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 7 
                 10 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCACAAACAGGATCCCCGAGGT 
                 1507 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCCTCGGCTGAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 7 
                 10 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGACACCAAGGCCCTGCGGCGGC 
                 1508 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAAGTGTGCCGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 7 
                 10 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGCTGGTCGGTGGCCACCACCA 
                 1509 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTAGTGAAGTTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 7 
                 10 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCTCTAGGCAGGCCCAGGCCCA 
                 1510 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTGCTTGTAACACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 7 
                 10 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCCCTGGAGCAGGCACTCACAT 
                 1511 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACCCCTCCACTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 3 
                 6 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTATAAAAGCAATAGAAGAAG 
                 1512 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTATCGTTTACCACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 3 
                 6 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGGTGAAGGCCAGCTGGGCAG 
                 1513 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCATGGGTGCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 3 
                 6 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAATGTTGGATTGTTGGCAAAAG 
                 1514 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGCGTGCTGAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 3 
                 6 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTAGAATTCCAACTATCTGTTCA 
                 1515 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATTTTGGCCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 3 
                 6 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAAATGATTCGAAACCCAAATA 
                 1516 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCTGAAAACTCACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 3 
                 6 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTAGGCATTTCTTACCTACTACA 
                 1517 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTTCCCAGGGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGGCGAGTTGCTCCTTCACTCG 
                 1518 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGACCAAGCGACACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGCTGCCGCCGCTGCTGCACCT 
                 1519 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTAGTCTTCTTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCTCTAGCAGCAGTGGTGACC 
                 1520 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCCCGCTTCTTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGGTCCCAATGAGTGCGGTCGG 
                 1521 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTTCCCGAGGAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCGTCTTGTCCGGGAGCCATGT 
                 1522 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCTCTCCACGGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCTTCGGACTCGGAGTCTGACC 
                 1523 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGAGCCAGTGGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGGACCTGCCCGTCGGGGAGGA 
                 1524 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTCTGCAAACGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCTGTGCCCATGCTTCTGTTTCC 
                 1525 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAGGTAGCCGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTACTTCGTGCTCAAACTCGAG 
                 1526 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTGCTGACGCCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCCTGGCATTTTCGTAGTATTCC 
                 1527 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCCGAGCTGGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTCCGGCACAGTGTCCGCGCCG 
                 1528 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGCGGCTGCAGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGGGGGATCGCGGCGCCAGAG 
                 1529 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCGGCCGCCGCTGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCATTCCACCGCGGCGCGTGAT 
                 1530 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACCCTATACCAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCTTGCATCTGCTCGCTGGCTCA 
                 1531 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGAAAAGCACACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 490 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCGACACCTCATTGCTCTTTTCA 
                 1532 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCAAGACGAAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 525 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCTCCGACTCGTTCTCGGCCACC 
                 1533 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCGCGAAGTAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 560 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAAAGCTGGTACTTGCTGCTCA 
                 1534 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCGCCTCATCCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 595 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCGAGCGTGCCGCAGCGGCGGC 
                 1535 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTTGCTCTCGAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 630 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGCAGCCGGACGGAGAGCCGG 
                 1536 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGCGCTGGCGGCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 665 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATCTTTATAGAAGGGTGGCTCC 
                 1537 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCGCCGCTGCCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 700 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTGGCAGGTAATAGTCAAACCC 
                 1538 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGGGGCTGGGGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 735 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACAGCCGGAACACGCCGCTCAG 
                 1539 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTTTTCTGTGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 770 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTAACCGACGAGGAGGTCGTGT 
                 1540 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGTGAGGCTGAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 805 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGGAGCTGGACGACCACGCTGG 
                 1541 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCACTTCGGTGTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 840 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCATCCGTCGCTGTGGACACTC 
                 1542 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAGCAGTATTTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 875 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACCGATGACAGTGGACCTGCCT 
                 1543 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTTCCAAGAAGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 910 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGGAGAGCTCTGGATGCAGGTC 
                 1544 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATGACTGTGTGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 945 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCTCCAAAAACAGCTCATGCAT 
                 1545 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTTTGGGCAACACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 980 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATGAGAGCCTTGTGTGCAGACG 
                 1546 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATACAGAGCCCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1015 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGGGCGCCGATGCTGATGCTGT 
                 1547 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCTGCGGCAGCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1050 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGTTAACCCTGCTGTCCGCTAG 
                 1548 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGGCACCTGGGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1085 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCTGAGCCAGCCTCCCGGCTCG 
                 1549 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCGGCACCAAGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1120 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTCCCGCTTTGAGCAGTTTTGCC 
                 1550 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCTCAGGGCCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1155 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGTGAAAAGCATCTCGTCTTC 
                 1551 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCGTCGCCGATACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1190 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGCTTCGTAACACCCAGCGAGC 
                 1552 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGTGGCCCACTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1225 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGCCCTCTGGGCAGGTGCAGTC 
                 1553 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCCTCGCCTGGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1260 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGTCAAGGAGAGCGGTTTCAGT 
                 1554 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCGGCCAGCTTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1295 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGGACGTGCTGGGCTGGGTGCT 
                 1555 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGCGGCGAAAAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1330 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCACCCTGCAGAAGCCCCGAAC 
                 1556 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATGGAGCTCGCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1365 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGCCAGAGCCAGAACCAGACAC 
                 1557 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCAGAAGACAGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1400 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTTGGGGAGGAAGGCAATCCCC 
                 1558 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGGCAAAGAAGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1435 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATAGGCATGTAGTCACCTCCGC 
                 1559 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCCTTCCTGATACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1470 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACAATTGGGGCTCAGGAAATGG 
                 1560 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGGGGCTCAGGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1505 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTACTGGAGCCTTGGCCATTTGAG 
                 1561 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCTGGCCACCTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1540 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCATAGCTCGGGAGGAAACCAG 
                 1562 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTTCAGGCGAGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1575 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCATTTGAGCCCTGACCACCTCG 
                 1563 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGATCCCTGTCCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1610 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGGGCTCAGGAGGAAACCAGT 
                 1564 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTCTAGAGATGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1645 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCACCTGAACCGTGCCCACCTG 
                 1565 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGTGCCCTGGCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1680 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCCAGAGACCTGGAGGTGGGC 
                 1566 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGGCTCAGGTGGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1715 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACCTGAGCCATGGCCATCTCCA 
                 1567 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTCCCTGGCCAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1750 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGGCAAGAACTCTGGGGGGGGC 
                 1568 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAGGCTCAGGAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1785 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCACGTTCACCATCACCATCGGA 
                 1569 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCTTTCCCACTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1820 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAATCTCTGAAGAAAAGATCCT 
                 1570 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTTTGGCAAATACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1855 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGTGGTGGCATTTGCTGTTGCTT 
                 1571 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTTTGAGTTAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1890 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCACCACCTCCTCCTCCACCCCCA 
                 1572 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAGCTGGAGGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1925 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAATCTTCCCCCAGACTTCCCTT 
                 1573 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCCACCAGTTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1960 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACTTTATTTTTGTGTTGACAGAG 
                 1574 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGCCACGAAAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 1995 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTGCATCTTTCACTTCTTTGGCT 
                 1575 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTTTGCATTCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2030 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATCCCAGAAGGTGCAGCTCGAG 
                 1576 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCCCCACAGAGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2065 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTATGGGTCATCCTCATCTTCATC 
                 1577 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAGCTCTGGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2100 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGCCAATGAGGCCAGGGGTGGC 
                 1578 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACCCCTCTTGTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2135 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTGAGGAGCCATTGGCATATAA 
                 1579 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCACTGGAGCTTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2170 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGTCTCTGCTTCAAAAAAGCGC 
                 1580 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACTCTCGATCCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2205 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACATCATCATGTACCCTCTTGA 
                 1581 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCTTCAAAAGGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2240 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCCAGAGTGAGCCCACCACCTG 
                 1582 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCCGAGTCCTCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2275 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAGTCATCCTCTTTATTAGTATC 
                 1583 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGTGCTTTTGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2310 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGGACAATGACAGTGAGAGTG 
                 1584 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTACATGTTTATACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2345 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGGGTTTTTTGGAATTGCACCG 
                 1585 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTCCAGGAGCCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2380 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAATCCTCAGGGTGGCTCTTCC 
                 1586 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCAAAAGTTGGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2415 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCCGAAAAGGGTTTGGTAGAGA 
                 1587 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAGTAGGAGCTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2450 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCACCTTTGGGACAGAATGACA 
                 1588 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAGTGAGTATGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2485 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCCCTCCCCAGGAACTTTCCAG 
                 1589 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTAACATTGGCAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2520 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTAGACAAAGAAGTCTCCTATAA 
                 1590 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGGGACCCCAAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2555 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGATCCCTCACCTGAAGGCTTT 
                 1591 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAGCTGCATCTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2590 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCAAAGCCTGGAGATGGGGGA 
                 1592 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCACCTTCAAAGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2625 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTAGCTTTATTCTTTGGGGGCTCA 
                 1593 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGATCTGAAGGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2660 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGACCTAACCGACTTTCTTTTAT 
                 1594 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACAAAAGGATACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2695 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGTGTGGGCTTTTGTGGTTTTGG 
                 1595 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTGATTTTATACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2730 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGCAGAGAGAAGCTGACAGCT 
                 1596 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTAGTGACTACGTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2765 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGTATTGCTCTCTCTTTTAGTGA 
                 1597 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTCCATGTTGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2800 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCTCCCTCTACTCAAGGACTA 
                 1598 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAGATTCGTGGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2835 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAAAGGCTGACTGTCTGGGTTC 
                 1599 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCAATTATGCCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2870 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAATTATGTGAATGTTGAGTTTG 
                 1600 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGTGCCATTTCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2905 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTTAAAAGATCTGAGAGGTCGT 
                 1601 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGCTGGATTTGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2940 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTATACCACGTGCCAACCCCTT 
                 1602 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCTCTGGACAGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 2975 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACTGAGGGGAAGGGGAGGAAG 
                 1603 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGCCACCTAGCAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3010 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTACAGGTAGCAATGCTATTGAG 
                 1604 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAGAGGGTGACACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3045 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTGTCATTGCTGAGTTGAAAAT 
                 1605 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACTTCAATGTAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3080 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCCATGGCTCTTGCTGACAGTG 
                 1606 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCATTCGCTATGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3115 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGGTCGACCACATAGATTCGAC 
                 1607 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGTTTCAGCATACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3150 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTTCTGAGTGCTGTATGGATATT 
                 1608 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTCTCTCCCCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3185 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCTAGCTACAGGTGGTGGTTCA 
                 1609 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAACATCGGCTGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3220 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCTGCAGGAAGAAGAGCAGGA 
                 1610 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGAAGACGCCCAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3255 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGCTGCTGCAAAGAAACTTTG 
                 1611 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAACGGCTTTGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3290 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCCGCTGTCTCTGCTTTTCCAAC 
                 1612 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGACAGCCTCGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3325 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACAGCCGGGGCTGAGGATGGG 
                 1613 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAAGGTCTCTCTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3360 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTTCGGCTGCAGAGCCGACTTT 
                 1614 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCCCTCAGCCAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3395 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGCTGCGGCGAGCGCGGAGGC 
                 1615 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGCAGCTACAACTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3430 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGGCATCGGCGCAGCAGCCGCA 
                 1616 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTGCTGGATTTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3465 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAACAGGTTGAAACCAGCGGGC 
                 1617 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAGGCGGAGTCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3500 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAATGCTGCTGATGCCGAAGCAG 
                 1618 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAAGGGGAGCCCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3535 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGGGCTCCAGGGTTCGAGCCAC 
                 1619 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGCAACGTCTTACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3570 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACCCATCTGCAAACCTTGCCAG 
                 1620 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGTGATAACCAACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3605 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGGAGCGGCAGCTGCAGCGGCA 
                 1621 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCCCGCCAGCCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3640 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACCACCACCTCGCAGTCGCCGG 
                 1622 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGCCAAGACCCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3675 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGTCGTCGTCGTTGTCAGAATCT 
                 1623 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTCTCTCCGGACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3710 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCACGTGAGAATGGATTTTGCCA 
                 1624 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACGTGATAATCACGCGTGGCGGATGT 
                   
               
               
                 IRS4 
                 NM_003604 
                 1 
                 X 
                 − 
                 3745 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTAAAATTACCGACCTCTTTTGG 
                 1625 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGAGTCGAACTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 1 
                 10 
                 + 
                 −34 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCCCTCCAGCCGTGGCCCCAGC 
                 1626 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCGCACGGGCGAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 1 
                 10 
                 + 
                 1 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACGCAGCCCCGCGGCACCGGACG 
                 1627 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCGCCTTCGCCAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 1 
                 10 
                 + 
                 40 
                 + 
                 25 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTTGCTGCTGCTGCTGCCGCTGC 
                 1628 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGGCAAAGGTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 1 
                 10 
                 + 
                 71 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCCTGCGGGAGCCGGCGGCCGG 
                 1629 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGAACTCACCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 14 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGGGAAGATCCCAATCAGGTG 
                 1630 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACATCACCAGAACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 14 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCTGGCTGACGTGAACTTGCGG 
                 1631 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGGCTATAGCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 14 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGTATGGAGTTATGGGATTGTT 
                 1632 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTGGGAGGTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 14 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACATCTCCCAGTATGGTCTCTCT 
                 1633 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCATAAGACATACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 14 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAATCAGGATGTAAGTATTTGTG 
                 1634 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCTATGAGTTAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 2 
                 13 
                 + 
                 −6 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGTAGGCTTGAGTTTGAAGAAA 
                 1635 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGAAGAACCTGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 2 
                 13 
                 + 
                 29 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGTATCTTTAATTTCTGACATAA 
                 1636 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCAGTAAAATACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 2 
                 13 
                 + 
                 64 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATCATGTCAGAGAGAGAGCTTG 
                 1637 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTAACTTGGGAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 2 
                 13 
                 + 
                 99 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCTTACCAATACTCCATCCACA 
                 1638 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATGAAACTTTCACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 7 
                 13 
                 + 
                 −14 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATTTTTTTTTCAGGGGAAGTATT 
                 1639 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAAATGGAAGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 7 
                 13 
                 + 
                 21 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACATAGCATTAACTGAAATGAAA 
                 1640 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCACCAGATCATACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 7 
                 13 
                 + 
                 56 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCCTTGACTATTTTATTAAACTC 
                 1641 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCACCTCCCATACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 7 
                 13 
                 + 
                 91 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAATTAAATACTTACTATATGGT 
                 1642 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTTTGAGCAACACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 17 
                 X 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTTCACCGTTGTTTGGAACCATC 
                 1643 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACAATTCAATACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 17 
                 X 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCATAGCATTATTCATGGCTTGTG 
                 1644 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGATAAAGTAAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 17 
                 X 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGAAAATGGACAGGCTGGTGCT 
                 1645 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCAGCCTGGTTACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 17 
                 X 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGAATCCATGGAACTGCATGTT 
                 1646 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTGGAATGCTGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 17 
                 X 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGTTGATGAGGACAGATTCAA 
                 1647 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGGAAATGGAAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 17 
                 X 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTCAAGTTGGTGTCCAGGATTA 
                 1648 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATATTCTGAAAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 17 
                 X 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAATGGGAACTCCATAGCACCTA 
                 1649 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACTGTGGACATACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 17 
                 X 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGGGGTCCCTCCGAAACGTAGC 
                 1650 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCTCCATTTCCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 17 
                 X 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCACTTCCCTGGTGGCAGGCCC 
                 1651 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTAGAGCAGATACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 17 
                 X 
                 − 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCAGATCTTCCCTTCTGCAAA 
                 1652 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAGCATTTTGCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 17 
                 X 
                 − 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGAGGTAAGGAATGCAAAATCA 
                 1653 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTAGTAGTCAATACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 13 
                 2 
                 − 
                 −8 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTAACAGCACCATCATCCATTG 
                 1654 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTTGGTCCAGGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 13 
                 2 
                 − 
                 27 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCCAGTGCCACACTGTATCTTG 
                 1655 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGACTTCTTTAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 13 
                 2 
                 − 
                 62 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCTGGAACCAGATCGGCCCAA 
                 1656 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGGGTAATCCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 13 
                 2 
                 − 
                 97 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTAATACCTTCTCATAATACTTGA 
                 1657 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTCATATTCCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 15 
                 X 
                 − 
                 −22 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTGATTTCATGTTTGTTTTAGGC 
                 1658 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCGTATAAATACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 15 
                 X 
                 − 
                 13 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGAATTCTATTGGGTCCTTTGATC 
                 1659 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACTGGATTTTACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 15 
                 X 
                 − 
                 48 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTGACTTTGGAGGATGTAACGT 
                 1660 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTATCAATCCCCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 15 
                 X 
                 − 
                 83 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAGAAGAGGATACTCCTTACCT 
                 1661 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACTGCCAAAGTACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 12 
                 X 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGAAGGACTTGCGTCATGAGAA 
                 1662 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATTAACCCTTTACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 12 
                 X 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCAAACATCCCCGAATCATAG 
                 1663 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGAAACCCAATACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 12 
                 X 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGTGACAGAATTCTGTTCCCGA 
                 1664 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGAGCCTAGAAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 12 
                 X 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGTCAAGTTTCACATCTTGATTT 
                 1665 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCAGTATGTCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 12 
                 X 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATGTTTAAATCATCACTCTTGCT 
                 1666 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGATCTCATAAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 12 
                 X 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAATCCAAGATTTCCTCAGTCT 
                 1667 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCCATTAACCTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 9 
                 12 
                 − 
                 −34 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTTTTTTCTGAGTGTTCAATCTC 
                 1668 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGTTTTCAGAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 9 
                 12 
                 − 
                 1 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGCCCGGGTCGGCGTCTCCGGC 
                 1669 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCGGCACCACAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 9 
                 12 
                 − 
                 36 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCAGGTCATCCTGCATCCGGTG 
                 1670 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCTCGAATCCAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 9 
                 12 
                 − 
                 71 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGAAAGGGGGAAGATGTCTCTG 
                 1671 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTCACTTACATACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 16 
                 18 
                 + 
                 −35 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACATTTAGTTTGTAATGTGCATGT 
                 1672 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTATTTATAGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 16 
                 18 
                 + 
                 0 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTCTGCTTGACTTTGTCTTGTTT 
                 1673 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCACCATGAGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 16 
                 18 
                 + 
                 35 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGTTTGTGGAGCCGTATTTTAA 
                 1674 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGTGATGAAAGACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 16 
                 18 
                 + 
                 70 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTCACATTGCTGGTATAAATAA 
                 1675 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAACCAACTTACACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 18 
                 4 
                 + 
                 −8 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCATGCAGTGTGTCCACCGTGAT 
                 1676 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGGCTGCTCGCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 18 
                 4 
                 + 
                 27 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCTTCACAATTTTTCCTTGTGCC 
                 1677 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGAGGACGTTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 18 
                 4 
                 + 
                 62 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGTGACTTTGGCCTGGCCAGAG 
                 1678 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACATCATGCATGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 18 
                 4 
                 + 
                 97 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGACGTACACTGCCTTTCGACA 
                 1679 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATAGTTCGAATACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 22 
                 1 
                 + 
                 −8 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTTTCAGGGAGCCATGGCTGCC 
                 1680 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACGTACTCCGCAACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 22 
                 1 
                 + 
                 27 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCTTCAGCTGGGGGGTGGGCTT 
                 1681 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAGCTGTTGAGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 22 
                 1 
                 + 
                 62 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATCGAGTCATCCATCCTGGCCC 
                 1682 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCGGCGAGTGAACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 22 
                 1 
                 + 
                 97 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTGGTGCCTCACAGGGTGGTGG 
                 1683 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGGCAACTTCCACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 1 
                 3 
                 + 
                 −26 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCTCACTGCCCTCTGCACCAGC 
                 1684 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACATGGATTGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 1 
                 3 
                 + 
                 9 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACAGAGCAGCTGAGAAGGAGGA 
                 1685 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGATGGAGAGCTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 1 
                 3 
                 + 
                 44 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCGACAGCTTCGGGGAACTGA 
                 1686 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCCGCAGCCTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 1 
                 3 
                 + 
                 79 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCGTGCGTCGCGGTACCTGGCT 
                 1687 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACCTTCATTGGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 16 
                 3 
                 + 
                 −9 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTTAAAGGCTTGAAGAGTGTC 
                 1688 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAATTATGTCCTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 16 
                 3 
                 + 
                 26 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTCTCCCAATTCAACCACAGTG 
                 1689 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCTTTTTGCAGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 16 
                 3 
                 + 
                 61 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGACATCATGTCAGAGTTACT 
                 1690 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTTCAGAACAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 16 
                 3 
                 + 
                 96 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTCCTTACCATCCCCATTTTTAA 
                 1691 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGATGATCTCAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 4 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTGCCCTGCAGGGACATTCAAG 
                 1692 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCAGCCAGGAAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 4 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGCTGTTGGAGGGGCAGTGGGA 
                 1693 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAGCCTTCAGCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 4 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCCCCTGCAGAGGCGTCTCCCA 
                 1694 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTGCACCTGTCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 4 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGAGGGTCAAAGTCCGCTCGGT 
                 1695 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATAACCGGTCCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 4 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAGTGGCATGCACTAGTAAGTG 
                 1696 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTAGTAATGGCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 2 
                 12 
                 − 
                 −3 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGGACATTCTTCTCTTCTGCTGG 
                 1697 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCTTTGAACAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 2 
                 12 
                 − 
                 32 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTCCATGAGCTTGGTGAAGGTA 
                 1698 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTCTCTCTTCTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 2 
                 12 
                 − 
                 67 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCTGGAGAAACTGCCAAAGCGA 
                 1699 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACCGTCGCCTGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 2 
                 12 
                 − 
                 102 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTACTCTGCAGACTTCCAGAAATG 
                 1700 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCAGGGTGAGAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 17 
                 12 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGGCAACCTTTCCAAACAAGAC 
                 1701 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGACCATCCAGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 17 
                 12 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGATTGTTCTCCTTCCCCGTCTCT 
                 1702 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCGTGGGCCAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 17 
                 12 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGTGTGCCCCCCGGAGCCCACCC 
                 1703 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGTGGATCCGCAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 17 
                 12 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTGGACGGGACCCTGGGGCTCT 
                 1704 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGAGAGATGGGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 17 
                 12 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCGTCCAGCACTATTGTCACAC 
                 1705 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGCCCCACTCCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 17 
                 12 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAAGCCTGTCCACGTGGGTGTAC 
                 1706 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAGGGGCCCCGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 17 
                 12 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGTGGACGCCTACCCGGGCTTG 
                 1707 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCCCGCCCCCGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 17 
                 12 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATGGGGGCAGGGAACGGTGGC 
                 1708 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGACTCCAGTGGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 17 
                 12 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCCCGGCAGCGGCACGCGGTCC 
                 1709 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCACCCCGCCGCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 17 
                 12 
                 − 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGCGGGGTCACGGTGGTGACGA 
                 1710 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTTGGGGGTGCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 17 
                 12 
                 − 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCACGCCGCCCATGAGGAAGA 
                 1711 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAACAAGCTGAAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 17 
                 12 
                 − 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTTTCGGGAGGAGGGCGGTGGG 
                 1712 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCCCCGGGGGCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 17 
                 12 
                 − 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGATACACTTGATCCCGGGATTC 
                 1713 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCGCGCTGCATACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 17 
                 12 
                 − 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGTGCCCCAGCTGGAACTCGTG 
                 1714 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGATTTGCTCCGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 17 
                 12 
                 − 
                 490 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGTGGACGAGGCCCACACGCCCA 
                 1715 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTGAGTGCGATACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 10 
                 12 
                 − 
                 −49 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGATGTCTCCCTGGGGACACTCA 
                 1716 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTTGATGTTTTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 10 
                 12 
                 − 
                 −14 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTATTTGTAGTAGTGGGATGCTT 
                 1717 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAAAAGAAAGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 10 
                 12 
                 − 
                 21 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCAGCAGTTCATCTTCCCAGGT 
                 1718 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGTTTCATGTGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 10 
                 12 
                 − 
                 56 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCGGGGCTTGTTCAGAAGGGG 
                 1719 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGCTTCCAGCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 8 
                 3 
                 + 
                 −18 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCTCTTCAACCTCACAGCTTTCT 
                 1720 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCATCTCTGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 8 
                 3 
                 + 
                 17 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGAAATGGCGATCATGACCAC 
                 1721 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGGCTACTTTCACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 8 
                 3 
                 + 
                 52 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCAGTAGCAATTATTCTCCTCA 
                 1722 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGTTGTCATCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 8 
                 3 
                 + 
                 87 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAACAGACTGTGAACTCACCTCC 
                 1723 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAATCAAAACATACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 19 
                 12 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCAAGCTGGTGAAGTACTTCAG 
                 1724 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGGCAGCTGTCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 19 
                 12 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGTTGCGCTCCTGCAAGGCTACC 
                 1725 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCTTTTTGCAGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 19 
                 12 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGAGCTGGACGGCTTCCCCCAG 
                 1726 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTACGGCACTGGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 19 
                 12 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCAGGACCTCCTTGCGCACATC 
                 1727 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACGATTCGGAAACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 19 
                 12 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTGACCTGGGGGGCCCCTGTGT 
                 1728 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCCTGCCCCTTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 1 
                 15 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCATTGAGTGCATTACCCAAGG 
                 1729 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCGTGTTTTGGAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 1 
                 15 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATCGTACACCTCTTTGGGGCAG 
                 1730 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTCGGGGCCGCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 1 
                 15 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCATGCTGGGGTGCTGGCAGAGG 
                 1731 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAACCACAGCAGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 1 
                 15 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGAGGATTTTGTAGATCTCCTTG 
                 1732 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGTTCAACCGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 1 
                 15 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCTTTGGGGAAGGCCACCCCAA 
                 1733 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTACCTGGACAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 1 
                 15 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAATTCATGACCACCAGCCACC 
                 1734 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTAGCCAAGAAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTGTGCTGGGCGATGCCAGGAG 
                 1735 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGGAAGTCATCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTGGTATGAGCCAGTCAGGAAT 
                 1736 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGTGGATGAGCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCTGGAGAAGACAGAGAGTGA 
                 1737 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTCTGAAGAGCCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCTGGATCCCTGACCCCAATGG 
                 1738 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTAGCTTACTATACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGAGATCAATGATTAGGCAGGT 
                 1739 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGAGACCAGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGTGCTTTTGCTATTATGGCCT 
                 1740 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATCCTTCCCCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGCATGGGGAGGTTTGGTGACC 
                 1741 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTCACCTCTGAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCACCTGTCCAGAAGAGTTGGA 
                 1742 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGGGTAACAGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGTACAAGAAAGAAATGTTGGT 
                 1743 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGATGGACAGACACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGCCCCAGCTTCCTCTCGGATTA 
                 1744 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCACCAGATGTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGATGCCAAGGTGAGGGTGGAG 
                 1745 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGTGGGGGACACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCTCCTTTGGCCAGTGCTGACC 
                 1746 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAGCCAGCCTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTCTGGTTTCCCAGGTCTTCATC 
                 1747 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGATTGGGTCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGCAAATGGAAAGTCAGACAG 
                 1748 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCTACTCCTCTGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 490 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCACTCCCCGCAAGTTCTCAG 
                 1749 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTGGGCAGATGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 525 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTCTCATCCTCCAGGCTGAAGA 
                 1750 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGAAGATCACAGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 560 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTTTCCAGGCTGTGAGCCGTCT 
                 1751 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCATGGGCAGCTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 595 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGGCCTCCTCGTCCCTCCCCGC 
                 1752 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAGGGAACTCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 16 
                 12 
                 − 
                 630 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTTGGCACTGGTGGGGACACAA 
                 1753 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTAAGGAGGGGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 3 
                 1 
                 + 
                 −12 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCCTCCATCAGGATGAGGGCGT 
                 1754 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTCAAGGAGATACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 3 
                 1 
                 + 
                 23 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCAGAGCCAGCCTTGACGTGG 
                 1755 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCGTGATGGAGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 3 
                 1 
                 + 
                 58 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGCTGATCCATCCCATTTCGAG 
                 1756 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCCTCAAGGTTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 3 
                 1 
                 + 
                 93 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCATGACTCACTTTGCCAAAGGA 
                 1757 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCCTGGCCCAGACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 14 
                 3 
                 + 
                 0 
                 + 
                 0 
                 23 
                 1 
                 1 
                 CGCGAATGCCATCTGAGATGCACAATAAAACAG 
                 1758 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTAGCCAGAGGTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 14 
                 3 
                 + 
                 35 
                 − 
                 0 
                 0 
                 2 
                 0 
                 CGCGAATGCCACATGCACGACAATAGGACTCCA 
                 1759 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAGCAGGCCAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 14 
                 3 
                 + 
                 70 
                 + 
                 0 
                 0 
                 2 
                 0 
                 CGCGAATGCCGGGATGTATTTGAAGCACCTGAA 
                 1760 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGGCAAGTCGAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 14 
                 3 
                 + 
                 105 
                 − 
                 0 
                 23 
                 1 
                 1 
                 CGCGAATGCCGAATGTCAGTTAAGTTAATGAGC 
                 1761 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTTCCATTGCCACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 14 
                 3 
                 + 
                 139 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCAAACAGGAGAAGAAGGATG 
                 1762 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAACACAAAAGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 7 
                 6 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGAATTCGGTGAAGTCTGCAGT 
                 1763 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCCGTTTGAAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 7 
                 6 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTATGGCTACTGCAACATCTCTT 
                 1764 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCCCTGGAAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 7 
                 6 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACCCTGAAAGTTGGTTACACAG 
                 1765 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAACAAAGGAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 7 
                 6 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGCCCCATGATGCTTGCTTCACA 
                 1766 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAAAAGTCTCACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 7 
                 6 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTGACCACCCGAATGTTGTCCAT 
                 1767 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGGAAGGGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 7 
                 6 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATAAAGATATAACCAATATCTA 
                 1768 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTCTTGTAACAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 18 
                 12 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGCATGCCCAGAGGCAGTTCGT 
                 1769 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTAGCTGCAGTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 18 
                 12 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTTGGCCACCTCATGTCGTCTG 
                 1770 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTTCTGCTCTCACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 18 
                 12 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGCTCTAAACCGCCTCAGGAAG 
                 1771 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGGCAGAGAGGACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 18 
                 12 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCTGGATGCTGTCCTGGAGTTC 
                 1772 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGGTCGTCCACACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_014770 
                 18 
                 12 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCATTGGACAGCATTCGAGGTA 
                 1773 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAGAAAGGTCAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGGCGAGCCCTCCGGAGAGCGA 
                 1774 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGCTTCTCGGAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTTGGGTTTGCGCAGGTAGCCC 
                 1775 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCTTGCGCACGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCATGCACAAACGCTTCTTCGTA 
                 1776 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGCGCGCGGCCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGTACTCGAGGCGCGCCGGGCC 
                 1777 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCAGCCTCGCTACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGAGAACGAGAAGAAGTGGCGG 
                 1778 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACAAGTCGAGCGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAGCAGCTCTCAAGGGGGATCG 
                 1779 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCGTTTGGGGGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACATCAACAAGCGGGCTGACTC 
                 1780 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAGAACAAGCAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAAGTGCTCGTCCCGGGTGTAG 
                 1781 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAGCCACCAGGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCATCGCGGCGGACAGCGAGGCC 
                 1782 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGCAAGACAGCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCACGGTTGTGCAGCTGTAGGAG 
                 1783 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCCTGGTACCAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAAGGGCCACCACGACGGAGCTG 
                 1784 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGCCCTCGGGGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGCTGCCGCTGCAGCTGCCCC 
                 1785 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACCACCTCCCGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCCTTGGTGAGGCTGGGGAGGA 
                 1786 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTGAGCTACGGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGACCTCTTTGAATGCGGGTCCT 
                 1787 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGGGCACGTCAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 490 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCAAGTGATCCTGAAGCCCAAG 
                 1788 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCCTGGGTCAGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 525 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGCAAAGGCGGTAGATACCAAT 
                 1789 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGGTTCTTTGTACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 560 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACCAGCAAGACCATCAGCTTCG 
                 1790 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAAGCTGAACTACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 595 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTCATCAGCTGCAGCACCACGG 
                 1791 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGCTGCCTCCGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 630 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCAGGCGCTGTGGCCACTCGGA 
                 1792 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAACTTCTTCTTACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 665 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGGCCCCGTCACGGCAGAACGG 
                 1793 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCACCTCGATGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 700 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGAGTTCTGGATGCAGGTGGAT 
                 1794 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACTCTGTGGTGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 735 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGGCCTCCAGGATGGTCTCGTG 
                 1795 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATGTTCTGGGCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 770 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGGGCCATGAGTGATGAGTTCC 
                 1796 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCCTCGCAGCAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 805 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATGGGGTTAGAGCAGTTGGACG 
                 1797 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGACTGGCTCTACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 840 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCGTCCCCCTGCGCCGGCACCA 
                 1798 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTCAACAATCCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 875 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGATCGGCGGGTCAGCCCCACC 
                 1799 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGCTGGGCGGGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 910 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCACTGAGAGCATCACCGCCACC 
                 1800 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCCCGGCCAGCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 945 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGACACGGAAGGAGCCTGGCTT 
                 1801 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCGCCCACCATACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 980 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCCTCCAGTGACGGCGAAGGCA 
                 1802 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCATGTCCCGCCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1015 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGGGACTCACAGGGCTGCCGT 
                 1803 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCACCGAGGCTGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1050 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCAACAGAACCCACGCCCACCG 
                 1804 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCATCGGGGCAGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1085 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCGGCTGTGGTTGAGCGGGGGG 
                 1805 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCAGCCGGGCGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1120 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCATCCCCATGCCGGCTTCCCGCT 
                 1806 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTCGCCTTCGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1155 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGCTACTGGACGACAGACTGAC 
                 1807 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGGCTGGTGGCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1190 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGTGGCCATGGCTCCACCTCGG 
                 1808 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTGTCTCTTCCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1225 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGGGAACCAGACACCGAAGCA 
                 1809 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTAGATCGCCGTGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1260 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCGATGGCGGTTTCATCTCCTC 
                 1810 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGATGAGTATGGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1295 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCGGAAGGAACTCCGGAAATCG 
                 1811 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGGGACTGGAGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1330 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGTCACTCCGGATTCCCTGGGC 
                 1812 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACACCCCACCAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1365 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGATATAGTTGCTTAGCTCCTCC 
                 1813 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCACCGCGGGCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1400 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATGGGTGGCAAGGGGCCCTCCA 
                 1814 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCTGACCGCCCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1435 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTGCCACCCCGAGACAAAATGT 
                 1815 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTGACCGTTGGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1470 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCCACCGCTGCACCCCAGGAAC 
                 1816 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGCTTGGGCACACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1505 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACTGGCTGCTTCATCCCCAGCC 
                 1817 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGGCTGGACTCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1540 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGCAGATCTGGATAATCGGTTC 
                 1818 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGAAAGAGAACTACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1575 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGTGGGTAATGGTAGGGGATGT 
                 1819 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCTGCCGAGTGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1610 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAGACCCCGTCCCAGTCCTCAG 
                 1820 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGCTTCCATTGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1645 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGTGGGTAGGCAGGCATCATCT 
                 1821 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGTGTACTCCTACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1680 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGGTGGCAGTGGAGGCCGACT 
                 1822 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCGGGACACAGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1715 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGGTAGGAGCGGGTGGGCACG 
                 1823 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGGCGGAGTGCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1750 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGAGGGTCTGGAAATGCACCCC 
                 1824 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGGAGCGTCGGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1785 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGAGGGTGGAGCTGTCTGGGCG 
                 1825 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGTGCCCCCCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1820 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACGGATGATGGCTACATGCCCA 
                 1826 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTCCCCAGGGGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1855 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCACTGCCCTTTCGGCCACTGG 
                 1827 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCACTGGGGCCAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1890 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACTATATGCCCATGAGCCCCAA 
                 1828 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGCGTATCTGCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1925 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATGGCGTCTGATGGGATTGATG 
                 1829 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCTGCTGTGGGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1960 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCAGAGAGTGGACCCCAATGGC 
                 1830 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACATGATGATGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 1995 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCCAATGTCAGGAGAGCAGCC 
                 1831 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCGCTGGGGGAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2030 
                 + 
                 23 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCCCCAGCAGCAGCAGCAGCA 
                 1832 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAGCAACGCCGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2065 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTCCACAGCTTTCCATAGCTGGT 
                 1833 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCGGAAGGGAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2100 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACGGGGTAGGGGGCCACCACTC 
                 1834 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCATGTCTTGCCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2135 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTACCACCGCTGCTCTCCACTGGG 
                 1835 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTTTGGGGTGAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2170 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCTCTTACCTTGCACAGGTGAC 
                 1836 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACATGAACATGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2205 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGGGGCTGCTGGTGTTGGAGTC 
                 1837 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCCACTGGTGAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2240 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGACTGCTACTACGGCCCTGAGG 
                 1838 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCCCCAGCACAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2275 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGATCTTGGCAATGAGTAGTAGG 
                 1839 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAGGACTGGCTACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2310 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTAAGCACACCCAGCGCCCCGG 
                 1840 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAGCCGGAGGAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2345 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGTGGAAAGGCGGAGGTGCTGA 
                 1841 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCCGGGCACCCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2380 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTCTGGTCGCCTTCTCTATGCTG 
                 1842 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAACAGCAGATACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2415 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCAGGCTGTCGCTGCTGGTGGA 
                 1843 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAGGAAGAATCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2450 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGGGGATACTGCGGGGCTAGGC 
                 1844 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGAGCCCAGCCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2485 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGGGGCTGCAGAACCTGATGGT 
                 1845 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGGATGTGGAAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2520 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGCCTCGAAAGGTGGACACAGC 
                 1846 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCTCAGACCAAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2555 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGGGACAGCCTCGTGGGCCGG 
                 1847 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCAGGCGGCTAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2590 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGATCCCAAGGCCAGCACCTTA 
                 1848 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTCGGGCCCGAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2629 
                 − 
                 18 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGAGGGTGCAGCAAGGGCTGCT 
                 1849 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTGCTGCTGCTACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2660 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCAGAGCCCAAGAGCCCGGGGG 
                 1850 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATATGTCAATAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2695 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGACAAGTAGCCAGACTGATCAC 
                 1851 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCCAAATTCAAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2730 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCCCGGTGGCTTTCCACAGCTC 
                 1852 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCTTCTGTCAGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2765 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCTCTGGGAGCTGGCTGGAGC 
                 1853 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGGATGGACACACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2800 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGAGACTGGCACTGAGGAGTAC 
                 1854 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGAAGATGGACACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2835 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCTCCTGCCAGGCTGCCCTCCG 
                 1855 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCCGGCCCCAGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2870 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACTGGGGTCGAGATGGGCAGAC 
                 1856 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGGCCCTGCACACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2905 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGGGTAGGCCTGCAAATGCTAG 
                 1857 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGCCCCGGGAGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2940 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGTGCCCAGCAGCCGGGGTGA 
                 1858 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTACATGACCATACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 2975 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTCCACGTAGCTCTGACGGGGA 
                 1859 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAACTCATCTGCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3010 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCGCCAGCTGCCCCTGTAAGC 
                 1860 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATGCTGACATGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3045 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCAGGCTCACCTCCTCTGCAGC 
                 1861 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATGCCTGTTCGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3080 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGGGCCACCATGGCTGCTGCCT 
                 1862 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTCATCCTCAGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3115 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCCCCTTGAGGCCCAGTCGGGG 
                 1863 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGCAGAGGCTGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3150 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGAGCTGGCTGCCCACTCGTC 
                 1864 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTGCTGGGGGGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3185 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGTGAAGGCGCTCATGCCCCCA 
                 1865 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTCCTTGTGGGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3220 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGTGAACCTCAGTCCTAACCGC 
                 1866 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACCAGAGTGCCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3255 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCCGGCACCCTTGTGGGTCTGC 
                 1867 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACGGATCACTTTACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3290 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGGCATAGCTCCGAGACTTTCT 
                 1868 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTCAACACCCAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3325 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCAAAGGGCACTGTGTTGCCCA 
                 1869 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCGGGTGGCACACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3360 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGGGGGCAGCAGTAGGGGGCG 
                 1870 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGCGGTAGCAGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3395 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGAGCTGTGGCGTTTCACATCC 
                 1871 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCGCTGCTGCTGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3430 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTTCCTTTGAGAATGTGTGGCTG 
                 1872 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGCCTGGGGAGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3465 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACAGTTTGGCTGGCTCCTTGGG 
                 1873 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCTCCCCCAAGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3500 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGGGCTGCTGGGGGTTTGGAGA 
                 1874 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGGTCTTAACTACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3535 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGTTTGAAGTCCTTGACCAAAT 
                 1875 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAGGTCTATGTACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3570 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCCCTCAGGAGTGCACCCCTGA 
                 1876 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCGCAGCCTCCACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3605 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCTGCCCAGGGGTTGATGAGGG 
                 1877 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTGGGGGTGGGACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3640 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGAGAGCAGCTCCACCCGCCGC 
                 1878 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAAGTGAGGATACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3675 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCTTCTGGAAACTGATGCTGGC 
                 1879 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATAGGCGCTTAAACGCGTGGCGGATGT 
                   
               
               
                 IRS1 
                 NM_005544 
                 2 
                 2 
                 − 
                 3710 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCAGAGGACCGTCAGTAGCTCA 
                 1880 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTGGACATCACACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 3 
                 18 
                 + 
                 −48 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATAAAGGAACTGTTGTAGAAGT 
                 1881 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATACCTTTTCTACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 3 
                 18 
                 + 
                 −13 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGGTTACTTTTACTTGTAAACCT 
                 1882 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAAAGTAAAAACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 3 
                 18 
                 + 
                 22 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTAAAACAGGAACGAATCTTGT 
                 1883 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGTATCAGTATACGCGTGGCGGATGT 
                   
               
               
                 RBBP8 
                 NM_002894 
                 3 
                 18 
                 + 
                 57 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATCAACTACTCTATAAATAACA 
                 1884 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATGAGTATTACACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 11 
                 15 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCCCCCACGTGTGGTGAGCCTG 
                 1885 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGGAGCCTGAGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 11 
                 15 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCACCACAAACTCGATGCAGTG 
                 1886 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCCAGGCGCAGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 11 
                 15 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCAACCCCCCACCAACGCTGC 
                 1887 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTGGCTGCACAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 11 
                 15 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGGATGATCTTGGACTCCCGCA 
                 1888 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGGCTGCCCATACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 11 
                 15 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGGAATACTACCAAGAGGGAG 
                 1889 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGATTTCCGAGGGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 11 
                 15 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTTGTAGTGGGTGGGCTTGTTG 
                 1890 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGAGCAGGCAGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 11 
                 15 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGGCAACTATACCCTCATTGCC 
                 1891 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAACCCACTGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 11 
                 15 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGAAGTGGCCATTGATGGTCTG 
                 1892 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTGGCTGTGCCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 11 
                 15 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAGGAGCCCTTTCCAGGTGAGG 
                 1893 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAGCGTAGCTGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 21 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGGCACCCCTTACCCCGGCATG 
                 1894 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGGTGGATTCTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 21 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCCGGTACCCACTCTTGATCTTA 
                 1895 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGTAGAAAGTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 21 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCCAAGCCTGACCACGCTACCA 
                 1896 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGAAGTGTGAGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 21 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACTGTGAACACAGGCCCCCGGG 
                 1897 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGGGGAAGGAGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 21 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTGGGTCTAGGGGGAGGGAGG 
                 1898 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCCCTGAGACTTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 21 
                 4 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGTGGGGACAGAACTCAAGAGT 
                 1899 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGCACAGGGGGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 21 
                 4 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTACGAGATCATGGTGAAATGCT 
                 1900 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAACAGTGAGCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 21 
                 4 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCACTCAGGTGGTAAAAGGAGG 
                 1901 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCTCTTCTCCGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 21 
                 4 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTGTGGAGAATCTGCTGCCTGG 
                 1902 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAATATAAAAAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 21 
                 4 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCCAGACCTTTCCACCCACAGA 
                 1903 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCAAACACACCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 9 
                 4 
                 + 
                 −6 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGCAGTTCCTTCATCCATTCTGG 
                 1904 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTTGGTCGATACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 9 
                 4 
                 + 
                 29 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCACCGTCTGTCCCCCAGTTGA 
                 1905 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCATGGTGATCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 9 
                 4 
                 + 
                 64 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGCACAGCTGAAGGCACGCCGC 
                 1906 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCCTGATATTGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 9 
                 4 
                 + 
                 99 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCATACTTCTTAATATCTTTGCA 
                 1907 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATCATCCACTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 13 
                 4 
                 + 
                 −18 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATTCTGCCTGCCCACAGGTCGG 
                 1908 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCTTGGGGTCTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 13 
                 4 
                 + 
                 17 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGGCTGTTCCTTCAACCACCTTC 
                 1909 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAAACGCTCCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 13 
                 4 
                 + 
                 52 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGATTAAGCCGGTCCCAACCTG 
                 1910 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCATGAAAGTTGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 13 
                 4 
                 + 
                 87 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGGAAGGAGCACTTACGTTTTA 
                 1911 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCATCTTCACTGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 13 
                 X 
                 − 
                 −25 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCATTCTCCTCCTTTTCTTTCTAG 
                 1912 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTGATTGGGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 13 
                 X 
                 − 
                 10 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCAAAATCTCCAAGGGAGAACT 
                 1913 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTTCAGCCACAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 13 
                 X 
                 − 
                 45 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACCTTAAGTCCATCAAATCAAG 
                 1914 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCAAGTGATGTACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 13 
                 X 
                 − 
                 80 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTACATAAACGAAGATTTCTCAT 
                 1915 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCATTTCGAACACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 17 
                 15 
                 − 
                 −32 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCTGACCGTTACCTTTCCTCCTC 
                 1916 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCTGCAGACAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 17 
                 15 
                 − 
                 3 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGTTGAGCGTGTGAAGACTGCGC 
                 1917 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGTTCTCTATGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 17 
                 15 
                 − 
                 38 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGTGGACATGGAGCTCTACACC 
                 1918 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGACTTCAAAAGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 17 
                 15 
                 − 
                 73 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGAAAGGCCTCTCTGTGGCCGG 
                 1919 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGTACTCACAGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 2 
                 19 
                 + 
                 −44 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTGCAGAATTTAACAGTTTACCC 
                 1920 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTGACACTTTACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 2 
                 19 
                 + 
                 −9 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCTGGTCTATCTTTGCAATCCAT 
                 1921 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCTGCAAATAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 2 
                 19 
                 + 
                 26 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTCCAGTTAAGAAGTTAATACA 
                 1922 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGTAATTATTTACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 2 
                 19 
                 + 
                 61 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTATAAACTACGAACAACTCTT 
                 1923 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAACCCATTTCCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 5 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGTCCTGACCTGGGGGCTGTG 
                 1924 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGCTGCGCATCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 5 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGTGCTCCACTCGGAAGTGGTG 
                 1925 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGCAGCTCTTCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 5 
                 19 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTGGCCGAGGGTGCCAAGAAC 
                 1926 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTACTGCGCCTGCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 5 
                 19 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACTGCCTTGCGGTCCGGGGCCT 
                 1927 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGCAGCGCTGAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 5 
                 19 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCGAGGTGAGGGGCGGAGCTTT 
                 1928 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATTAGAGGCGGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 20 
                 12 
                 − 
                 −24 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCAGTGCGAACTGGTCCAAAA 
                 1929 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATGATAGACTTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 20 
                 12 
                 − 
                 11 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTGGTCCTAAGCCCTTCCAGGT 
                 1930 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGAGATGCTCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 20 
                 12 
                 − 
                 46 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGCTACCTCCAACGACCTCACA 
                 1931 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAAAAGAAATCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 20 
                 12 
                 − 
                 77 
                 − 
                 1 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCCGTAGGCAACACCTACCTCC 
                 1932 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGGTCCGGATTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 17 
                 6 
                 − 
                 −22 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAATAAAACCTGCTCATGCACCA 
                 1933 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGTTTTTCAAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 17 
                 6 
                 − 
                 13 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATGTAGCATAAAATAATCCATG 
                 1934 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGGGTACCGAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 17 
                 6 
                 − 
                 48 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCTGCTCCGCTTTGCACACAC 
                 1935 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGGGAGGCGCAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 17 
                 6 
                 − 
                 83 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTGCTTTCCCATCACCTTACCTT 
                 1936 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTTCGCAGCCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 16 
                 4 
                 + 
                 −12 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTTCATTCCAGTGTCTTACACTT 
                 1937 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCAATCATCCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 16 
                 4 
                 + 
                 23 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCTAGTAGATCCCTCACAAGTT 
                 1938 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGAATGAAGGTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 16 
                 4 
                 + 
                 58 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCACATCTGGTTTGATTTCTGAT 
                 1939 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACATTATCAAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 16 
                 4 
                 + 
                 93 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATTTCTGCTTACCTGGTACAGAT 
                 1940 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATTTCTCATGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 15 
                 2 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTGCAAAATTGGATATTACAAG 
                 1941 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTCTCTCCACGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 15 
                 2 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGCTGTGGGGTGGGCACTTGGC 
                 1942 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAGGTGGCATCACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 15 
                 2 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCTGTCTGGGAAGGAGCCACCT 
                 1943 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGTGCACCTGTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 15 
                 2 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCAGCATCGTTGTCAGCTCTGA 
                 1944 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAGCCTCGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 15 
                 2 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTATGCCCTGCACCCGTAAGTT 
                 1945 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTATGCTTGTCTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 11 
                 13 
                 + 
                 −31 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATGTGAATGACTTCACTTATTGT 
                 1946 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATTTAGTTTTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 11 
                 13 
                 + 
                 4 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCAAGGTTACTTTTTCGTGGTGTT 
                 1947 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTGTGTTTCACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 11 
                 13 
                 + 
                 39 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAAGAGGTGAATGTAATTCCTC 
                 1948 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACACACTCCAGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 11 
                 13 
                 + 
                 70 
                 − 
                 11 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATAATTAAAAGTAGGAAAATTC 
                 1949 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATACCTAACTGGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 8 
                 2 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGAATTTGGTGAGGTATGCAGT 
                 1950 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGCGTCTCAAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 8 
                 2 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGATAGCCACACAGATCTCTCT 
                 1951 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTGCCAGGCACACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 8 
                 2 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACTCTGAAAGCTGGTTATACAG 
                 1952 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAAACAGAGGAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 8 
                 2 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGTCCCATGATGCTGGCCTCACT 
                 1953 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGGAAGTCTCACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 8 
                 2 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTGACCATCCGAACATCATTCA 
                 1954 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTGGAAGGCGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 8 
                 2 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGTAAAGGGGGTGACCCACGTA 
                 1955 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATTTAGTGACCACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 14 
                 13 
                 + 
                 −42 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTAAAATAGCAGGCTCTTATTTTT 
                 1956 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTTTTGTTTGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 14 
                 13 
                 + 
                 −7 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATACAAGCGAACTCCAAGTTTG 
                 1957 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATCGCTACAAAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 14 
                 13 
                 + 
                 28 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCGAGTAATGGAATCCATGCTT 
                 1958 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAATCAGTAAGTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 14 
                 13 
                 + 
                 59 
                 − 
                 8 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCCGGCTGAAATTTTTTTATATT 
                 1959 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTTTTAACTTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 13 
                 16 
                 − 
                 −46 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCTGGGGTCGGCGACGGCTGCT 
                 1960 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTTTCGTTCTGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 13 
                 16 
                 − 
                 −11 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGCTTCCCGGGAGGCTCGTCCA 
                 1961 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCGGGCAGGCGAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 13 
                 16 
                 − 
                 24 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCAGCTGTGAGGAGAAGGAAA 
                 1962 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGTGCCGGGGGTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 13 
                 16 
                 − 
                 59 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGCGGGGTCAGAGTCCTGCGTC 
                 1963 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGCCCTTCCCGCACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 12 
                 3 
                 + 
                 −39 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTGTACTGATTATTATTTATTAT 
                 1964 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTACTGTATATACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 12 
                 3 
                 + 
                 −4 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGTATTCTGTGACAATCATAAC 
                 1965 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGCTTACCTAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 12 
                 3 
                 + 
                 31 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGAATGGTTCCTTGGATAGTT 
                 1966 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCTACGTGTAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA3 
                 NM_005233 
                 12 
                 3 
                 + 
                 66 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTATTCATATATATGTATGTGT 
                 1967 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGCATCTTACACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 13 
                 13 
                 + 
                 −12 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTACCTCCTAAAGAACTGCACAGT 
                 1968 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAATCCAAAAGAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 13 
                 13 
                 + 
                 23 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTATCCTATATCCTTCACTCTTT 
                 1969 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAGTATACTTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 13 
                 13 
                 + 
                 58 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTTTAAAGAGAAATTTGCTAAA 
                 1970 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTGTGGGACAGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 13 
                 13 
                 + 
                 93 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTCAAGTTACCTGTGATCCAATT 
                 1971 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCGACACAACCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 2 
                 1 
                 + 
                 −48 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCGTGTAAGTTCTGACAGTGCTC 
                 1972 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCCAATCTCCTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 2 
                 1 
                 + 
                 −13 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTCCCCTGAGGTCTGTCCATTCT 
                 1973 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAAAAGAGAAACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 2 
                 1 
                 + 
                 22 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGCTGGACTTCAGCCGTCCAAG 
                 1974 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGAGGACCATGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 2 
                 1 
                 + 
                 57 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGATCCCCCACAGCCCCTCGCT 
                 1975 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGGGTGCTGGCACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 6 
                 13 
                 + 
                 −36 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCCTGTTTTTTTTCTGCTTTCTAT 
                 1976 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGTTTAATAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 6 
                 13 
                 + 
                 −1 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGCACCAATGCAGAATTTATTT 
                 1977 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGTAGATATCCACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 6 
                 13 
                 + 
                 34 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAAGTTTCTTGGATCACATTTTTA 
                 1978 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTAGCTAAAGGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 6 
                 13 
                 + 
                 69 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAAATATTAGCATTTAATAAAT 
                 1979 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATAATGAACTTAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 15 
                 19 
                 + 
                 −20 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCCCTCTCTTGCCCTGCAGAGGT 
                 1980 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAAGCCCCGTACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 15 
                 19 
                 + 
                 15 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCCACACCACCCCCAGCTCCGG 
                 1981 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGCGGCTCCACACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 15 
                 19 
                 + 
                 50 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGGACACCGGCAAGGCCACCCT 
                 1982 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACCTCGAGCCCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 15 
                 19 
                 + 
                 85 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACATACGTCACCCCTGCTCTCAG 
                 1983 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATGCACCCAGTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 18 
                 10 
                 + 
                 −20 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGTCTGCTCTTCCCACCAGGTAC 
                 1984 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGCCTGATGCTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 18 
                 10 
                 + 
                 15 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCGGCCTTTTGTCCGGCTCCTGCT 
                 1985 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCAGCATTGCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 18 
                 10 
                 + 
                 50 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTTTGCGGACATCAGCAAAGAC 
                 1986 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGGAGAAGATGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 18 
                 10 
                 + 
                 85 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATTGGACCCAGGCACTCACTCT 
                 1987 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTCTTAACCATACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 17 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACGCCCTTGCACTTGGCAGTGAT 
                 1988 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACTAAGCAGGAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 17 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGCCCCAGCCCTCAGCAAATCC 
                 1989 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCACCACATCTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 17 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCTGAGCCTTCTGGACCGCTTG 
                 1990 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTAACTCTGTTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 17 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTTTATCATGTCCTTCTTTGGCA 
                 1991 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTAGGTGCAAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 17 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCAGTATCTTACTCAAGCACA 
                 1992 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAGGCAGCACACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 17 
                 4 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCTTACCGTCCCCGTTGGGGTG 
                 1993 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCAAGAAGTAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 5 
                 4 
                 + 
                 −20 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTTAACGTTCACCTTTGCAGAGA 
                 1994 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGATTTCGTTTCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 5 
                 4 
                 + 
                 15 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTCCACCATGGGATGGGCCTTC 
                 1995 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACATACATAACGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 5 
                 4 
                 + 
                 50 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCTGGTGCCTCTAGTGAAAAGA 
                 1996 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAAGAAGTCTTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 5 
                 4 
                 + 
                 85 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGAGCTACCACAAACTTACTT 
                 1997 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGACCTGAGGGTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 11 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGAGTTTGGAGAAGTGTACAAG 
                 1998 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGCGTTTGAAAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 11 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGATGGCCACGTAGATTTCCCTC 
                 1999 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGCCTGGCAGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 11 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACCCTGAAGGCAGGGTACTCGG 
                 2000 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAAGCAGCGTCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 11 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGCCCATGATGCTCGCCTCAC 
                 2001 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCAGAAAGTCCCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 11 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCGACCATCCTAACATCATTCGC 
                 2002 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGGAGGGTGTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 11 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGTGATGATCATGACAGGCCGA 
                 2003 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTTGGTGACCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 11 
                 3 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTTCATGGAGAATGGTGCATTG 
                 2004 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATTCTTTCCTCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 11 
                 3 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTGCATCATCAAACCCCTGAGT 
                 2005 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCTCTTACCCTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 15 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCTTCCCAGCCCCTGCTCGACC 
                 2006 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTCCATCCCAGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 15 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGCCAGTCATCCACGGTGGTAA 
                 2007 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGCCGTGAAGTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 15 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCGCCATCAAAATGGTCCAGTA 
                 2008 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGGGACAGCTTACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 15 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGACCAGCTGGAGGGAGGTGAA 
                 2009 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCAGCAGTGAGGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 15 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCAGATGACATCAGAGTAAGTG 
                 2010 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGAGAATCTCTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 6 
                 3 
                 + 
                 −27 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGTATATACCTACTTTTTTCTTT 
                 2011 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGATCTATGTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 6 
                 3 
                 + 
                 8 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATAAGGGTTCTCCTCCATGGTAG 
                 2012 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATACCTGTTCGAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 6 
                 3 
                 + 
                 43 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGACAATGTGAACACTCAAAGA 
                 2013 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTACCTTGTTCCACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 6 
                 3 
                 + 
                 78 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAATATAAATCTATATACTTCC 
                 2014 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTACCTGGGATTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 6 
                 15 
                 − 
                 −4 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACAGATGTGCAGCACATTAAGAG 
                 2015 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGAGACATCGTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 6 
                 15 
                 − 
                 31 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCCAAAGGCTCCCTCACCCAGT 
                 2016 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTCGCTTCAGCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 6 
                 15 
                 − 
                 66 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGTCTTCCTGGCCGAGTGCTAC 
                 2017 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACCTCAGCCCGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 6 
                 15 
                 − 
                 101 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTACCTTCACAGCCACAAGCAT 
                 2018 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTGTCCTTGGTACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 14 
                 19 
                 + 
                 −22 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCGTGTACCCTGTCTGTCCAGA 
                 2019 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGGTGCTGAAGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 14 
                 19 
                 + 
                 9 
                 − 
                 6 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCTCCGTGTCTGCCTGGAAGCC 
                 2020 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCCATGTCTTCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 14 
                 19 
                 + 
                 52 
                 + 
                 9 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGAGGAGGGCGACTGTATGATC 
                 2021 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGATGTCCCGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 14 
                 19 
                 + 
                 83 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTATCTACAGCCCTTCTCACCCG 
                 2022 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGCATCCGGGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 8 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCGGGAAAAAGAGCTAATCCGC 
                 2023 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAGCAGCTCTGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 8 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGCACCACGCTGAGGTCCATCTC 
                 2024 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTGGTCTGCTGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 8 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTCATGTTTACAGCTTTTCTTCC 
                 2025 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGATAGCACTGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 8 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGATACCACGGGTTCCAGGCGCC 
                 2026 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGTGAAGCTGCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 8 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACGCCATCTATGACAGTAGTGA 
                 2027 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTACTTCACTTCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 13 
                 1 
                 + 
                 −18 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCCACCCCACTGTGCAGAAGCT 
                 2028 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATACCGTCGTGAACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 13 
                 1 
                 + 
                 17 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGAGCCACTGCTGGCTTGAAG 
                 2029 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTGGCTTGATCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 13 
                 1 
                 + 
                 52 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGATGACACCTTCTACTTTGACA 
                 2030 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGAGTTCACGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 13 
                 1 
                 + 
                 87 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAACAGATAAGGGACGCACCCTT 
                 2031 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGTGTGCGGGAACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 14 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCATCAATGCCATCGAGCAGGA 
                 2032 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTACCGGCTGCCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 14 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGGTGTAGAGCAGCTGGACAG 
                 2033 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCATGGGTGGGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 14 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCATGCTGGACTGTTGGCAGAAG 
                 2034 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACCGGAACAGCACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 14 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTAGGGTGTTGACAATCTCCGC 
                 2035 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAACCGGGGCCGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 14 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAAGATGATCCGGAACCCGGCAA 
                 2036 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCTCAAGACTGACGCGTGGCGGATGT 
                   
               
               
                 EPHB1 
                 NM_004441 
                 14 
                 3 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTTTCACTAGACTCACACGGCGG 
                 2037 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGATGGTTGCCAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 12 
                 15 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCAATCTGAACTGGACCAATGT 
                 2038 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCATGCCATCAAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 12 
                 15 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATTGTCCTCACTCGTCACATTCA 
                 2039 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAGCGTCAAGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 12 
                 15 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTTCACCCTGACGTGCATTGCA 
                 2040 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGAACGTGGTGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 12 
                 15 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGACAGTGAGGGCAACACTGGC 
                 2041 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATTGCTCATGCCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 12 
                 15 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGTAAGTGCATGTTATTGTGGG 
                 2042 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGATGGCTGTGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 4 
                 6 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTGGAAAAATTCCAGTAAGGTG 
                 2043 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACAGCACCCGAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 4 
                 6 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACTGGCTGATGTGAATTTCCGG 
                 2044 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACTGGATGGCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 4 
                 6 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGTATGGAGCTATGGAATAGTC 
                 2045 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGTGGGAAGTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 4 
                 6 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACATGTCCCAATAAGGTCTTTC 
                 2046 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCATAAGACATACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 4 
                 6 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAATCAAGATGTAGGTGTTACAT 
                 2047 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCATTTAAACAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 14 
                 6 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTGTGGCCGTGGGTTCTACAAG 
                 2048 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTTCCTCTCAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 14 
                 6 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAACTGTGAGTTGGACAACGAGA 
                 2049 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCACTGAAGATCACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 14 
                 6 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCTGATAAAGAAGGCTCCTCCA 
                 2050 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATGTGAATGTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 14 
                 6 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGTGGGTCAGATGGAGCCCTGT 
                 2051 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATACCCATCTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 14 
                 6 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTACGTTGCGTGCACAAGTGAGTT 
                 2052 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTATTATGAAAGACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 12 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATAAAGAAGAAGTGCAGAGGAA 
                 2053 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACGTCAGAAGCTCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 12 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTACCACCGCCGAAACTATCCGA 
                 2054 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAATTGGGCATACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 12 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGTGCTGGAGCTGGAGGCGGAG 
                 2055 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCATGTTTGGTAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 12 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCTGTACTTCCAGTGCCCCCTCC 
                 2056 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCACCGCCACACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 12 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGGTACAAAAATACTTATTCT 
                 2057 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCTAAAACTTTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 21 
                 4 
                 + 
                 −36 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGTATAACGATTTCTGGTGTTTT 
                 2058 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTTTCCAACAACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 21 
                 4 
                 + 
                 −1 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTCATATGGTTTCCCATTTAATA 
                 2059 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTCAAATACCACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 21 
                 4 
                 + 
                 34 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGAGTTTACATCTGATGATTTA 
                 2060 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTAGCACAAGGTACGCGTGGCGGATGT 
                   
               
               
                 NFKB1 
                 NM_003998 
                 21 
                 4 
                 + 
                 69 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATAATGGTTAAGAGAATCTGGTT 
                 2061 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTATCACAACCCACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 7 
                 2 
                 − 
                 −39 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCATCAAAGGTTTGTGTTTTTCT 
                 2062 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCTGAAAACTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 7 
                 2 
                 − 
                 −4 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGTACTCTGTTATGATCATTACT 
                 2063 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTTTACCTAGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 7 
                 2 
                 − 
                 31 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGAATGGCTCCTTGGATGCAT 
                 2064 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCTCAGGGTATACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 7 
                 2 
                 − 
                 66 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTACCAACATTCTTGGGTTTAATAT 
                 2065 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAGTAGTCACACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 17 
                 10 
                 + 
                 −1 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATGGTCTTTTGGTGTCCTGCTGT 
                 2066 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGAGATCGTGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 17 
                 10 
                 + 
                 34 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGGAATCCCAGGATAGGGGTT 
                 2067 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCCCCTAGGGTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 17 
                 10 
                 + 
                 69 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAGCGGCTCTTCAACCTTCTGA 
                 2068 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGACCGGCCACCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 17 
                 10 
                 + 
                 104 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATCTCCTCGCTGCAGTTGTCTGG 
                 2069 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTCTCCATCCACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 12 
                 2 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATCAGAATGAGCGAAGCTATCG 
                 2070 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATAGTTCGGACACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 12 
                 2 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTTCAGGCCTTTGATATCTGTGT 
                 2071 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCTGGCAGCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 12 
                 2 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCTCACTTCCTATGTTTTCCACG 
                 2072 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCGAGCCAGGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 12 
                 2 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGGGCTCACTGAAGTCTCCATA 
                 2073 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCAGCTGCTGTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 12 
                 2 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGGTTACAACCAACACAGGTA 
                 2074 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAAGGACCACCACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 1 
                 12 
                 − 
                 −66 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACAACGGATGACATCATCATGTC 
                 2075 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTGTGACCTCTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 1 
                 12 
                 − 
                 −31 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCCTGGAGTGGGGAGAGAAG 
                 2076 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAGAGAGTGGTGACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 1 
                 12 
                 − 
                 4 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGACCTTTGGACATCGGGACGGC 
                 2077 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCCAGCTGCCTACGCGTGGCGGATGT 
                   
               
               
                 KSR2 
                 NM_173598 
                 1 
                 12 
                 − 
                 39 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGACAGAGTAGGGAGGGAGAG 
                 2078 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGACGGGAGCCCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 7 
                 16 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATCCTTCAGGTTCCTGTTCCGTA 
                 2079 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GATGTGAGTGCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 7 
                 16 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGGCTCTTTACAACCGGCTCTTT 
                 2080 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCAAAACATGACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 7 
                 16 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTATCATAACTGCTTGCGAAGAT 
                 2081 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTAGTTTCTCTTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 7 
                 16 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTTTTTCCCACTGCCAAGCATCC 
                 2082 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAGCTTTCCAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 7 
                 16 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTATACCTGGCACTTCGCAGAGG 
                 2083 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAAGTGGGAATCACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 18 
                 3 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAATGTTACCTTATGGTTGTCTGTC 
                 2084 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATCGGTGACTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 18 
                 3 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGAGAATTTCGCACCACCTCAA 
                 2085 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAAGTCCCACACACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 18 
                 3 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTATTATGCAAATTCAGTGCAA 
                 2086 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGCGGCTTGAAACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 18 
                 3 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGATGTAGTGTGTGGCTGTTGAAC 
                 2087 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCAGTGCACCTACGCGTGGCGGATGT 
                   
               
               
                 PIK3CA 
                 NM_006218 
                 18 
                 3 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTGGCTCAAAGACAAGAACAA 
                 2088 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGAGAAATGTGAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 6 
                 12 
                 − 
                 −36 
                 + 
                 24 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATTCTATCTCTATCTCCTTCGCT 
                 2089 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCGGGAAACCAACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 6 
                 12 
                 − 
                 −5 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGATTTTAGTTTCCACATTTTGC 
                 2090 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTTGGCTGGTACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 6 
                 12 
                 − 
                 30 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTGGTAGTTTAAGAAATATTTAT 
                 2091 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAGCAGGTAACACGCGTGGCGGATGT 
                   
               
               
                 CENTG1 
                 NM_001122772 
                 6 
                 12 
                 − 
                 65 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACCCCAGCTGAGCGCCCCTCCC 
                 2092 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCTCCCCACTTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 12 
                 6 
                 − 
                 −8 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAAACAGCTCCCTCGCAAGTGA 
                 2093 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGAGTAATGAACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 12 
                 6 
                 − 
                 27 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAAAGCTCGACACTCCGCTGCA 
                 2094 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTACTCTCTCCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 12 
                 6 
                 − 
                 62 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCAGGAACCAGAGCATCCCAA 
                 2095 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGAGTCATCACACGCGTGGCGGATGT 
                   
               
               
                 EPHA7 
                 NM_004440 
                 12 
                 6 
                 − 
                 97 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACTTACTTTCTCGTAATACTTGA 
                 2096 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTCATATTCTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 15 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCCCATTTACATCATCACAGAG 
                 2097 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATTGCTTCTATACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 15 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCCTATTCTTATGCAAATAGTTG 
                 2098 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCAAATCTCCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 15 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAGCTTCCTGAGCCACCACCCAG 
                 2099 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAAGCCAAAGAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 15 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCAGCAGGGTTCAATCCAAAGA 
                 2100 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATCCAGCTCTTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 15 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAAGCACACGGAGGTGGGTGC 
                 2101 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAGAGAGATGTTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 8 
                 10 
                 + 
                 −7 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTGCAGATGTGGCCGAGGAGGC 
                 2102 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGCTGCCCCCTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 8 
                 10 
                 + 
                 28 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACACTCCAGCCGTCTCTTGCTG 
                 2103 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTGCACAGGACACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 8 
                 10 
                 + 
                 63 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGAGTGTGGCGGCCTGGGCTCC 
                 2104 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCAACAGGCAGGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 8 
                 10 
                 + 
                 98 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCTTACCTTTGCCATCTCCTTGC 
                 2105 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCCACTCACAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 4 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCCAGATGTAGCCTTTGTACCT 
                 2106 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTAGGAATGACGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 4 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGAATCATCATCCTCCACGAT 
                 2107 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACTAAATAATCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 4 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATTATACCTTGTCGCACAACTG 
                 2108 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCCCGAGACTCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 4 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGTACCACCCCCTCACTGTTGT 
                 2109 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTAAGGTTACAGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 4 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCTCCTACGACAGCAGACAGGG 
                 2110 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTTAATGGGACACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 4 
                 4 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGTGGCCTCACAGATATAGGGC 
                 2111 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTACAGTGAAGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 4 
                 4 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCAAAGGAAAGAAGTTCCAGACC 
                 2112 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCCCATTTAATACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 4 
                 4 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGGAGATGATACAAGTACCTTT 
                 2113 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAAAGCATAAACACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 15 
                 10 
                 + 
                 −8 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCACAGCTCGTTCATCGGGAC 
                 2114 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGGCAGCCAGAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 15 
                 10 
                 + 
                 27 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCTTCATCTTCCGCCCCTCAGCT 
                 2115 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCAGGATGTTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 15 
                 10 
                 + 
                 62 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCGGATTTCGGCTTGTCCCGAG 
                 2116 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGTTTATGAAGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 15 
                 10 
                 + 
                 97 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTGGGCACCTGGCTCCTCTTCA 
                 2117 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGTAGGAATCCTACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 19 
                 1 
                 + 
                 −32 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGACTGACCACCTCCCCTGCCC 
                 2118 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTTGCCAGGTGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 19 
                 1 
                 + 
                 3 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGTCGCAGCCTTCATCGTAGCC 
                 2119 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGGCGCTTCAGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 19 
                 1 
                 + 
                 38 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGAGCCTGGGCATTCTGCTGT 
                 2120 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACACCATGCTGGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 19 
                 1 
                 + 
                 73 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGGGGAAGGGTCCAGGCCAGG 
                 2121 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCACTCACCCTGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 16 
                 13 
                 + 
                 −2 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGAAGAAGAACGATTATCCATT 
                 2122 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAAAATTTTAGGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 16 
                 13 
                 + 
                 31 
                 − 
                 33 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAAAAAATTTTTTACTAAAAGT 
                 2123 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAAAATTTACCACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 16 
                 13 
                 + 
                 74 
                 + 
                 31 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAGTAAGTATTTTATAATCTTTT 
                 2124 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTTTTTCCTTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 16 
                 13 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGAAAAATGTTGTCATTCAGAA 
                 2125 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTTGCTAAAGGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 16 
                 13 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGTCTTTATTGGCGTGCGCTCTT 
                 2126 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGGTTGTAATACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 16 
                 13 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTTATGAAAATTTAACTTACTGC 
                 2127 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATATGTGGCCACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 7 
                 1 
                 + 
                 −16 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCCTGTCTTTTGCAGGTGATGTT 
                 2128 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACGGAGGAGGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 7 
                 1 
                 + 
                 19 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCCAGAGCCAGCTCAGCCAGGT 
                 2129 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAAACTTCACATACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 7 
                 1 
                 + 
                 54 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGATCACCTGCACAGCCTGGG 
                 2130 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATCATTTACAGACGCGTGGCGGATGT 
                   
               
               
                 RPS6KA1 
                 NM_002953 
                 7 
                 1 
                 + 
                 89 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGAGGCTTCACTCACTTCTCA 
                 2131 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCTTGAGGTCTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 3 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGGCCCCCAGTCCCCTGGTGCG 
                 2132 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTGGCCCCACCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 3 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGCCCGCCACGCGGCTCAGGTT 
                 2133 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTGGCCGAGCAACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 3 
                 19 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGAAGCAGTTGGCCATTGAGC 
                 2134 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAAGGTGAAGCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 3 
                 19 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTGCTGTAGGTCTGGATCATGTT 
                 2135 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCCGCCCCCTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_002741 
                 3 
                 19 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCAGCACCAAGGTGAGGCAGC 
                 2136 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACGTGCACACACAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 16 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTATGTTATTTTATCTTTTGAAAA 
                 2137 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAATGGTGACTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 16 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATACTGTGTAGTATCAGCCTGCTT 
                 2138 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATGTCCATGTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 16 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTCCCCATGCTAGAAAGGAAAGA 
                 2139 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTTTCTAAATAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 16 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGGACGATCATAGAGTGATCTC 
                 2140 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGATGTCGGAAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 16 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTCATATAAGAAGAAATCTATG 
                 2141 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTAGGTAAAAGTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 25 
                 13 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACTTCTGAGAAGTTCCAGAAAAT 
                 2142 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAATCAGATGGTACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 25 
                 13 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCACTTCTTTTGAGCACACGG 
                 2143 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCGCTGTTACATACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 25 
                 13 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGGAAGCAACCCTCCTAAACCA 
                 2144 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGAAAAAACTAACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 25 
                 13 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCATCTGCTTCATCTGATCCTTCA 
                 2145 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATATCAAAGCGACGCGTGGCGGATGT 
                   
               
               
                 RB1 
                 NM_000321 
                 25 
                 13 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGGTAGGAACCAGTTTTGAATG 
                 2146 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTTTCCAGTAGCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_213560 
                 1 
                 19 
                 + 
                 −50 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTGGGGCTGAGGTTCAGGAAGA 
                 2147 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGCGGGGCCCTACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_213560 
                 1 
                 19 
                 + 
                 −15 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGGTTATTGGCCTCCGCCATCCT 
                 2148 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGTCCGGGCTGACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_213560 
                 1 
                 19 
                 + 
                 20 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCGGAGCAGGAGCTGGAGGTGG 
                 2149 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTCCAGGGTCCACGCGTGGCGGATGT 
                   
               
               
                 PKN1 
                 NM_213560 
                 1 
                 19 
                 + 
                 55 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCCACTTGGGGCCCCCTTCTGCC 
                 2150 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCCCCCACAGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 10 
                 4 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGTAATAATGAAACTTCCTGGA 
                 2151 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTATTTTGGCCAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 10 
                 4 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAGTGGATCTCCGTGATGATGT 
                 2152 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTGAGACATTGTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 10 
                 4 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGAGACAGGAGTACCGTGGAGG 
                 2153 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCGTGTGACTTTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 10 
                 4 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCATCGCACGGCGATGGTCTCC 
                 2154 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCACTTTGGCGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 10 
                 4 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGCTAAGAATCTCCTTGGAGCT 
                 2155 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAGAACCGAGAGACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 10 
                 4 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGTTGAGGAACTCACTGGGAGC 
                 2156 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACCAGCTTCAGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 14 
                 15 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGTTGGAGCAGAACTTTTTCA 
                 2157 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACTGCAGCTGTGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 14 
                 15 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCCTGCTCCTGCCAGAGCTGCA 
                 2158 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCAGCGGATGTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 14 
                 15 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGGCCAAGCTCAACAGCCAGA 
                 2159 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCTCTACTGCATACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 14 
                 15 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGCGGAAGAGAGGAAGCTGGGA 
                 2160 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCATCAGCGTTGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 14 
                 15 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAACATCAGTCAGTGTGGTGAG 
                 2161 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAGTGGCCGCCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCGTCTGCCGTTTAAGCGCCTG 
                 2162 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AATCTTGTCCCAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCTGATCGTCTGACATGTCATC 
                 2163 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCTTTCCCCTTACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTACTTCTGTGCAAAGTAAAAGCC 
                 2164 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGATTTAGAGGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACATGACAGTTGTTTTCCAAGG 
                 2165 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTCCAAAGAGGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTTCTGACATAGACTTTAGACC 
                 2166 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GAAACTTGTCAAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATTTCTTAAAAAGTTATCTAAG 
                 2167 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGACCCTTCCCGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAATCGAAACCAGTATTGGCCAG 
                 2168 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGCACAGTCATCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTGGCTGCTCATTCGAGTCCTCT 
                 2169 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCAAATCAATACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGTCTTGTGGACCACAATAAAC 
                 2170 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAAATTCTGAAGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 315 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCGCTGGCCATTTATTGCCTCCCT 
                 2171 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGAGGGAGAGGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 350 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAAGACACTGGGGATCAGCAGG 
                 2172 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTTGTTGAAGGCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 385 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTCTCCAGGAAATGCCAACTTG 
                 2173 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCGTTCTGAATGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 420 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCCTTTCAGACATTCCTTGCAAA 
                 2174 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAGAGGAGGAGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 455 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCGCCTCTCCTCCCTGCACCTCCA 
                 2175 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGCCAACACCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 490 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCCCAGGAATGTTCGCCACGGA 
                 2176 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTGCCCGGAGCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 525 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCCTTTCTGGGGCACATTCTCGG 
                 2177 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCACTCGTCAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 560 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGGACAGTTGGAGTGAAGCTGG 
                 2178 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGGCATCCTGTTACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 595 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGTCCTGCAAGACCACCATAGGC 
                 2179 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCTTCCCTTTGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 630 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTTGGCTGTGAGACCACCGCAA 
                 2180 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCAAGTCCCTTACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 665 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCAGGGGTCATGTTCTTGCCTTGG 
                 2181 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGTGTGGCTGGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 700 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGTGAGGTGCTGGAATCTTTCC 
                 2182 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCGAAGAAGACTACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 735 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGAGGGAGAGCTCAGGGACGAA 
                 2183 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGGCTGAGTACAGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 770 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCACCAGCTCGCCCGAGGGGCC 
                 2184 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCTGCTCCCCCACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 805 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGGTGGGGAAGGGACTGGTACTG 
                 2185 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGTGCTGCTTTACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 3 
                 19 
                 + 
                 840 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCACGCCCCTCCGCAGAGTGAGT 
                 2186 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCTCCCATGGAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 18 
                 2 
                 − 
                 −24 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGAGCAGCGTTGGCACCGGCGAAC 
                 2187 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATGGCTGGGATACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 18 
                 2 
                 − 
                 11 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCCCGAAGAGACACGAAAATAG 
                 2188 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCGAAATAGAAAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 18 
                 2 
                 − 
                 46 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTTGCGACGCTGTCACAGGTTCC 
                 2189 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGGTATACCCCACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 18 
                 2 
                 − 
                 81 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACAGAAAGGCCGTCCCGCTCTT 
                 2190 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCTTCATTCGCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 18 
                 X 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTAATCATCATGTGTATGCATTCA 
                 2191 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTTTGATTGGGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 18 
                 X 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAGCACATTCCAAGAGATGCAT 
                 2192 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGAGTCTCTCCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 18 
                 X 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGATCTGAAAATGACTGATGGAA 
                 2193 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTACGTCTTTGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 18 
                 X 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATAAGGTAAACTGTAGAGCAGGG 
                 2194 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATCATAAGGAAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 18 
                 X 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAAGCACACCCCCTACCGGGTCCT 
                 2195 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGGAACAACCCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 18 
                 X 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGTCAACACTGCATCATAGGCT 
                 2196 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCCGGAGCTTTACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 18 
                 X 
                 − 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTACAGTGGAGTCCCAAGAAAAG 
                 2197 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACCTTCTATCAAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 18 
                 X 
                 − 
                 245 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGAATTTCACCTCTTGCTGCTGCC 
                 2198 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTGTGAAGGCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 18 
                 X 
                 − 
                 280 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGAGAAGCTGGAGTTCGATCAAG 
                 2199 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAAGTACACATTACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 11 
                 19 
                 + 
                 −24 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCTTTTTTTTTTCTCCTTTTGAGG 
                 2200 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGATGATGAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 11 
                 19 
                 + 
                 11 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAACCATCGTCCTCATCTTCATCCT 
                 2201 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCCCATGTCGACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 11 
                 19 
                 + 
                 46 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCTTTGTGCCCCATGGGTACCTGT 
                 2202 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGAGGACGAAACGCGTGGCGGATGT 
                   
               
               
                 CHAF1A 
                 NM_005483 
                 11 
                 19 
                 + 
                 81 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACCTCCCCCTTCACTCCCTCACC 
                 2203 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCTGTCACACCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 6 
                 10 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGCTGGTTCTCAACCGGAACCTC 
                 2204 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCATCTCGGAGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 6 
                 10 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCATTGACCAGCACCGCCAGCTG 
                 2205 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CATGGTGCGGTTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 6 
                 10 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTCAGACTTCCAGGGCCCAGGAG 
                 2206 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGGCGTCCTCTACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 6 
                 10 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCTGACCGGCAGCACCGACACGT 
                 2207 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGAAGTGGAGCAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 6 
                 10 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGCACCTGCCCAGTACCTACTC 
                 2208 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTCTCCGTGAGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 6 
                 10 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGGGCTCACCTGGGCAAATCGG 
                 2209 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGAGCCCTCCTGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 9 
                 15 
                 − 
                 −38 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCTAACTGTCCTCCTCCTTTTTG 
                 2210 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGTTTGGTTTTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 9 
                 15 
                 − 
                 −3 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTGATAGGAGGTGTGGGACTCA 
                 2211 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTTCGTCAACTGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 9 
                 15 
                 − 
                 32 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGACCCACAAACCAGAAGAAG 
                 2212 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACACTTTTGGGGTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 9 
                 15 
                 − 
                 67 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGTCAACACACTCCTCTTGACC 
                 2213 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AAGAAGTGACTCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 5 
                 4 
                 + 
                 −4 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATAGCAACATCAGAGCTGGATCT 
                 2214 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGAAATGGAAGCACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 5 
                 4 
                 + 
                 31 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAATCGTTTCCCCTGACTTATACA 
                 2215 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGTTTTAAGAACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 5 
                 4 
                 + 
                 66 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTGGTCACCTGTGCTGTTTTTAACA 
                 2216 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGAGGTGGTTACGCGTGGCGGATGT 
                   
               
               
                 PDGFRA 
                 NM_006206 
                 5 
                 4 
                 + 
                 101 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTACCACTTCTCCAGGGTAAGT 
                 2217 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCATTGAAGGTCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 13 
                 10 
                 + 
                 −16 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGTGCTGCATTTCAGAGAACGC 
                 2218 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCCCCGAGTGAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 13 
                 10 
                 + 
                 19 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCAGGACGTTGAACTCTGACAGC 
                 2219 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGTCTCGCAGCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 13 
                 10 
                 + 
                 54 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCAGGTCAACCACCCACATGTC 
                 2220 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATCAAATTGTATACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 13 
                 10 
                 + 
                 89 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCTGCAGCTGGCCTTACCATCCTG 
                 2221 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTGCAGGCCCCACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 3 
                 16 
                 − 
                 −26 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGCTTATTTATTTTTGTTATCTA 
                 2222 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGAATTTAAAACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 3 
                 16 
                 − 
                 9 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATCAATGTGCATCTTTTTCAGGA 
                 2223 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTTGACCAGTTACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 3 
                 16 
                 − 
                 44 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATTCTTACCAAGCTTCAGTCTGTC 
                 2224 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACAAAGCCTATACGCGTGGCGGATGT 
                   
               
               
                 PALB2 
                 NM_024675 
                 3 
                 16 
                 − 
                 79 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGTGGTCCCAGCCAGTCATTACT 
                 2225 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TACCATTTCAGAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 5 
                 2 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGGTGGCAAGATTCCTATCCGGTG 
                 2226 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GACTGCGCCAGAACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 5 
                 2 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCACTTGCTGATGTGAATTTACGA 
                 2227 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TAGGCAATTGCTACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 5 
                 2 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGTATGGAGCTATGGAATCGTT 
                 2228 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ATGTGGGAAGTGACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 5 
                 2 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGACATATCCCAATAGGGCCTCTC 
                 2229 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCGTACGACATACGCGTGGCGGATGT 
                   
               
               
                 EPHA4 
                 NM_004438 
                 5 
                 2 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAATCAAGATGTAAGTCTCTATG 
                 2230 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TTCTGAAATATAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 13 
                 15 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCACCTTCCTGAGATCAGCGTGAGC 
                 2231 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CACGTCAACCTGACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 13 
                 15 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAAGTGATAACAGCGTTGTCACC 
                 2232 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTCTCGTACGGTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 13 
                 15 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAATGGCTCTGGATCACCCCTTC 
                 2233 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CTGATGTGGACTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 13 
                 15 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGAGTGTTGATGGACTGCAGCC 
                 2234 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CAGTGACTATCCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 13 
                 15 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCAGGTAGGCATCCTGGGCTTCAG 
                 2235 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCCCATCAGGAGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 4 
                 10 
                 + 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGAGGGTCTGCCCTTCCGCTGC 
                 2236 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCCCCGGACAGCACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 4 
                 10 
                 + 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCGCGGTCCAGGGCCCAGCGCGT 
                 2237 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCTCACCTCCAGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 4 
                 10 
                 + 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGCGGGAGAAGTACGAGCTG 
                 2238 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGCCGTGTGCAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 4 
                 10 
                 + 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATCACCACCTCCTCGCGCGCGC 
                 2239 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGCGTGCACGGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 4 
                 10 
                 + 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTGCCCTTCCCGGTGACCGTGTA 
                 2240 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGACGAGGACGAACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 4 
                 10 
                 + 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCGGTGTCGACGCCCGCGGGGAAG 
                 2241 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTGGGCGCCGAGACGCGTGGCGGATGT 
                   
               
               
                 RET 
                 NM_020630 
                 4 
                 10 
                 + 
                 210 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCAGCGCCGTGGTGGAGTTCAAG 
                 2242 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CGGAAGGAGGTGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 7 
                 X 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATCAGTTGCTGAATCTCTCAAAA 
                 2243 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGGGCTGCACAGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 7 
                 X 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGTACAAGGTGACCAAGTCAAAGC 
                 2244 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 CCTCAGGTTCAAACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 7 
                 X 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTTCAGCGACATTGTGGGCTTCAC 
                 2245 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AACCATTTCAGCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 7 
                 X 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTCAGAAGATCCACGACCTCAATG 
                 2246 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GGCTCACTCATGACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 7 
                 X 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCATGACCTGTACACACTCTTTGAT 
                 2247 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GCAATAATTGGCACGCGTGGCGGATGT 
                   
               
               
                 GUCY2F 
                 NM_001522 
                 7 
                 X 
                 − 
                 175 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCCTGCTAATTAACCTACCTTGTAG 
                 2248 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 ACATCATGACTACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 5 
                 15 
                 − 
                 0 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCCCTGAAGGATCCCACCCTGGC 
                 2249 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TGCCCGGAAGGAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 5 
                 15 
                 − 
                 35 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCGCAGGTTGGTGAGCAGCTCGGCC 
                 2250 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TCCCTCTGGAAAACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 5 
                 15 
                 − 
                 70 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCAGCATGAGCACATTGTCAAGTTC 
                 2251 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 TATGGAGTGTGCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 5 
                 15 
                 − 
                 105 
                 − 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCTATTCAAAGACCATGATGAGGGG 
                 2252 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 GTCCCCATCGCCACGCGTGGCGGATGT 
                   
               
               
                 NTRK3 
                 NM_001012338 
                 5 
                 15 
                 − 
                 140 
                 + 
                 0 
                 37 
                 1 
                 0 
                 CGCGAATGCCCATGAAGCATGGAGACCTGAATA 
                 2253 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 AGTTCCTCAGGTACGCGTGGCGGATGT 
               
               
                   
               
            
           
         
       
     
     While the preferred embodiment of the invention has been illustrated and described, it will be appreciated that various changes can be made therein without departing from the spirit and scope of the invention.