Patent Publication Number: US-2020299239-A1

Title: Reaction composition and reaction system using this

Description:
TECHNICAL FIELD 
     The present invention relates to a reaction composition which includes a catalyst and an organic solvent, and a reaction system used the reaction composition. More specifically, the present invention relates to a reaction composition which includes a catalyst used in a hydrogenation reaction of one or more nitro groups of an unsaturated cyclic compound (aromatic nitro compound) having a structure where one or more nitro groups are directly bonded the ring skeleton, and an organic solvent. Further, the present invention relates to a reaction system which realizes, by using the reaction composition of the present invention, that the nitro group of the aromatic nitro compound of a reactant can be selectively hydrogenated, and the removal of the halogen atoms from the ring can be sufficiently reduced. 
     BACKGROUND ARTS 
     An aromatic halogen amine having a structure where one or more nitro groups and one or more amino groups are directly bonded as substituents to a ring skeleton of the same ring while separated from each other, is an important raw material of a medicine, a dye, an insecticide, a herbicide. 
     The aromatic halogen amine can be prepared, for example, by the hydrogenation reaction (catalytic hydrogenation reaction) of an aromatic halogen nitro compound having the corresponding chemical structure (aromatic nitro compound having a structure where one or more nitro groups and one or more halogen atoms are directly bonded as substituents to a ring skeleton of the same ring while separated from each other). 
     In this hydrogenation reaction, in addition to the reduction reaction (desired hydrogenation reaction) where the nitro group is reduced to an amino group, a reaction where a halogen atom is removed from the ring and replaced by a hydrogen atom (undesired side reaction. Hereinafter referred to as “dehalogenation reaction” as necessary) also happened. Hydrogen halide produced by the dehalogenation reaction corrodes the reaction vessel. 
     In general, it is known that the dehalogenation reaction of an aromatic halogen compound is accelerated under the condition that a noble metal catalyst such as Pt or Pd and a base (NaOH, KOH, NH 4 OH) coexist (for example, Non-Patent Documents 1 to 6). The reason why accelerating the dehalogenation reaction is that the base neutralizes the hydrogen halide generated by the dehalogenation reaction. This is described, for example, in Non-Patent Document 1, page 25, left column: Formulae (11) to (13) showing Liquid Phase Dechlorination Reaction, Non-Patent Document 3, page 98, left column: Formulae (1) to (3) showing Liquid Phase Dechlorination Reaction. 
     As explained above, in the hydrogenation reaction of the aromatic halogen nitro compound, it is important to sufficiently reduce the dehalogenation reaction and to selectively reduce the nitro group. 
     Various proposals have been made for selectively reducing the nitro group of the aromatic halogen nitro compound. 
     For example, in order to avoid the dehalogenation reaction, Patent Document 1 proposes that the hydrogenation reaction of the aromatic halogen nitro compound (an aromatic nitro derivative having a halogen atom bonded to an aromatic nucleus in Patent Document 1) is carried out in the presence of tungsten carbide and a strong acid (sulfuric acid, phosphoric acid, hydrochloric acid, hydrobromic acid). 
     Further, in order to selectively proceed the hydrogenation of a nitro group of the aromatic halogen nitro compound, Patent Document 2 proposes a noble metal catalyst in which Pt and Cu are finely dispersed on an activated carbon as a carrier in a predetermined supporting amount. 
     Furthermore, in order to selectively proceed the hydrogenation of a nitro group of the aromatic halogen nitro compound (for example, 1-nitro-3,4-dichlorobenzene, 4-nitrochlorobenzene), Patent Document 3 proposes a catalyst containing a Pt-supporting carbon and Fe oxide-supporting carbon (or Fe hydroxide supporting carbon). 
     Furthermore, in the hydrogenation reaction of a nitro group of the aromatic halogen nitro compound (4-chloro-2,5-dimethoxy-1-nitrobenzene), in order to isolate the reaction product 4-chloro-2,5-dimethoxyaniline without crystallization from the solvent (xylene), Patent Document 4 proposes a reaction system which includes a sulfurized Pt-supporting carbon catalyst, an aliphatic open chain amine (particularly morpholine), an alkaline aqueous solution {compound which gives a pH of 8 to 10 in an aqueous solution (for example, disodium borate, sodium formate, sodium acetate, sodium carbonate, disodium hydrogen phosphate, sodium hydroxide)}, a predetermined amount of water (30 mL in Example 1 of Patent Document 4, 1.5 mL of water contained in the catalyst), and a predetermined amount of an aromatic organic solvent (675 mL in Example 1 of Patent Document 4) 
     Incidentally, the present applicant submits, as publications where the above-mentioned publicly-known inventions are described, the following publications: 
     PRIOR ART LITERATURE 
     Patent Document 
     
         
         Patent Document 1: Japanese Patent Laid-Open Application H5-271105 
         Patent Document 2: Japanese Patent Laid-Open Application H6-71178 
         Patent Document 3: U.S. Pat. No. 4,212,824 
         Patent Document 4: Japanese Patent Laid-Open Application H2-45452 
       
    
     Non-Patent Document 
     
         
         Non-Patent Document 1: General Remarks Detoxification of Aromatic chloride compound (Soda and Chloride, 2005, January-February) 
         Non-Patent Document 2: Y. Ukisu et al., Appl. Catal. A: General., 271(2004) 165-170 
         Non-Patent Document 3: Y. Ukisu et al., Appl. Catal. B: Environ., 27, 97(2000) 97-104 
         Non-Patent Document 4: R. H. Mizzoni et al., J. Am, Chem. Soc., 73, 1873(1951) 
         Non-Patent Document 5: M. M. Robimson, J. Am, Chem. Soc., 80, 6254(1958) 
         Non-Patent Document 6: E. V. Brown, J. Org. Chem., 30, 1607(1965) 
       
    
     SUMMARY OF INVENTION 
     Problem to be Solved by the Invention 
     However, in the hydrogenation reaction of the aromatic halogen nitro compound, from the viewpoint of sufficiently reducing the dehalogenation reaction and selectively reducing the nitro group, the present inventors have found that there is still room for improvement even in the abovementioned conventional technique. 
     The present invention has been completed considering the abovementioned technical circumstances, and can provide a reaction composition which, in a nitro group hydrogenation reaction of an aromatic nitro compound having a structure in which nitro groups and halogen atoms are directly bonded as substituents to a ring skeleton of the same ring while separated from each other, is capable of selectively hydrogenating the nitro groups and sufficiently reducing the removal of the halogen atoms from the ring. 
     Means for Solving the Problems 
     As the results of the present inventors&#39; intensive study for solving the above problems, the present inventors have found that a structure of a reaction composition where a catalyst in which, in addition to Pt particles, Fe oxide particles are supported on a carrier is mixed with a predetermined base and a predetermined organic solvent is effective, and then the present invention has been completed. 
     More specifically, the present invention is configured by the following technical elements. 
     Namely, the present invention provides: 
     (N1) a reaction composition comprising 
     a catalyst which is used in a hydrogenation reaction of at least one among one or more nitro groups present in a reactant to an amino group, the reactant being an aromatic nitro compound having a structure in which one or more nitro groups and one or more halogen atoms are directly bonded as substituents to a ring skeleton of the same ring while separated from each other, 
     a base, and 
     an organic solvent which can dissolve at least a part of the reactant, wherein: 
     the catalyst comprises a support, and Pt particles and Fe oxide particles supported on the support, and 
     the base has a basicity stronger than at least one aromatic amine obtained as a product from the hydrogenation reaction and having one or more amino groups. 
     In carrying out the selective hydrogenation reaction of the nitro group of the aromatic halogen nitro compound, despite the general recognition of those skilled in the art that addition of a base in this chemical system promotes the dehalogenation reaction as described in the aforementioned Non-Patent Documents 1 to 6, the present inventors have intentionally tried to add a base in a chemical system of a catalyst in which Pt particles and Fe oxide particles coexist, which have not been attempted in the past. As a result, though the detailed mechanism has not been found, in the hydrogenation reaction of the nitro group of the aromatic halogen nitro compound, the reaction composition satisfying the above configuration can selectively hydrogenate the nitro group, and the removal of the halogen atom from the ring can be sufficiently reduced. 
     In the present invention, the “basic” when comparing the basicity between a base and a product (at least one of aromatic amines having one or more amino groups) means “pKa (=−log Ka)”. Here, “Ka” represents a concentration acid dissociation constant. In the present invention, the “state in which the base has a basicity stronger than the product” means that “the pKa of the base is larger than the pKa of the product”. Further, when comparing the pKa of the base with the product pKa, it is not necessary to use the base pKa and the product pKa as measured in the actual reaction system. For comparison of the pKa, the Ka and pKa of each compound defined and described in “Revised 5th Edition Chemical Handbook Basic II (edited by The Chemical Society of Japan)”, or the Ka and pKa of each compound described in the stability constant database summarized by the V6 Committee of IUPAC (L. D. Pettit, K. J. Powell, “Stability Constants Database”, Academic Software (1997)). 
     Here, the reaction composition of the present invention described in (N1) may further contain 
     (N2) the aromatic nitro compound. 
     Further, in this case, the reaction composition described in (N2) may further contain 
     (N3) an aromatic amine obtained by the hydrogenation reaction of the aromatic nitro compound as a reaction product and having at least one amino group. 
     Furthermore, from the viewpoint of obtaining the effect of the present invention more reliably, in the reaction composition of the present invention described in any one of (N1) to (N3), it is preferable that 
     (N4) the base and a component of a solvent used in the hydrogenation reaction satisfy the condition of the following equation (1): 
       0.90≤{1000×( B/Vs )}≤190.00  (1)
 
     in the equation (1), B being a substance amount (mol) of the base, and Vs being a volume (L) of the organic solvent. 
     When adjusting an amount of the base contained in the reaction composition within the range which satisfies the condition of the above formula (1) with respect to a volume of the organic solvent contained in the reaction composition, the effect of the present invention can be more reliably obtained. 
     Further, from the viewpoint of obtaining the effect of the present invention more reliably, in the reaction composition of the present invention described in any one of (N1) to (N4), it is preferable that 
     (N5) the base and the reactant used in the hydrogenation reaction satisfy the condition of the following equation (2): 
       0.35%≤{100×( B/R )}≤75.50%  (2)
 
     in the equation (2), B being a substance amount (mol) of the base, and R being a substance amount (mol) of the reactant. 
     When adjusting an amount of the base contained in the reaction composition within the range which satisfies the condition of the above formula (1) with respect to a substance amount of the reactant in the reaction system where the reaction composition is used, the effect of the present invention can be more reliably obtained. 
     Further, from the viewpoint of obtaining the effect of the present invention more reliably, in the reaction composition of the present invention described in any one of (N1) to (N5), it is preferable that 
     (N6) a component of a solvent used in the hydrogenation reaction satisfies the condition of the following equation (3): 
       0.00%≤{100×( Vh/Vs )}≤30.00%  (3)
 
     in the equation (3), Vh being a volume (L) of an introduced water other than the yielded water, and Vs being a volume (L) of the organic solvent. 
     The present inventors have found that by setting the water content in the reaction system where the reaction composition of the present invention is used to be relatively small as mentioned above, the reaction composition of the present invention can exhibit the effect of reducing the dehalogenation reaction more reliably. This structure is different from the catalyst described in Patent Document 4 (catalyst having a structure where the Fe oxide is not contained and used in a reaction system where contains water), and shows a remarkable effect obtained through the investigation by the present inventors. 
     Furthermore, from the same viewpoint, in a case of the reaction composition (N6), it is more preferable that 
     (N7) the water satisfies the condition of the following equation (4): 
       1.00%≤{100×( Vh/Vs )}≤5.00%  (4)
 
     Further, any one of the reaction compositions of any one of (N1) to (N5) may further contain 
     (N8) a dehydrating agent. 
     When previously mixing the dehydrating agent, the water content in the reaction composition of the present invention can be reduced, and there is a case where the effects of the present invention can be obtained easily. 
     Further, the present invention provides a reaction system comprising a reaction vessel which can accommodate at least one of the reaction compositions according to any one of (N1) to (N8) as a reactant. 
     According to the reaction system of the present invention, since the reaction composition of the present invention is used, it can be realized that the nitro group of the aromatic nitro compound of a reactant can be selectively hydrogenated, and the removal of the halogen atoms from the ring can be sufficiently reduced. 
     Effect of the Invention 
     The present invention can provide the reaction composition which, in a nitro group hydrogenation reaction of an aromatic nitro compound (aromatic halogen nitro compound) having a structure in which nitro groups and halogen atoms are directly bonded as substituents to a ring skeleton of the same ring while separated from each other, is capable of selectively hydrogenating the nitro groups and sufficiently reducing the removal of the halogen atoms from the ring. 
     Furthermore, the present invention can provide the reaction system which can realize that the nitro group of the aromatic nitro compound of a reactant can be selectively hydrogenated, and the removal of the halogen atoms from the ring can be sufficiently reduced. 
     Means for Solving the Problem 
     In the following, preferred embodiments of the present invention are explained in detail. 
     The reaction composition of the present embodiment contains the catalyst, the base, and the organic solvent. The catalyst contains the support, and the Pt particles and the Fe oxide particles supported on the support. The base has a basicity stronger than at least one aromatic amine obtained as the product from the hydrogenation reaction and having one or more amino groups. Furthermore, the organic solvent has chemical properties that the solvent can dissolve at least a part of the reactants. 
     The catalyst is not particularly limited as long as the catalyst contains the support, and the Pt particles and the Fe oxide particles supported on the support. 
     The support of the catalyst is not particularly limited as long as the support can support the Pt particles and the Fe oxide particles and has a large surface area. Examples include a carbon-based material such as an activated carbon, a pulverized activated carbon, a grassy carbon (GC), a fine carbon, a carbon black, graphite, or a carbon fiber, or a glass-based or a ceramic-based material such as an oxide, and may be properly used. 
     The specific surface area of the support is preferably 500 m 3 /g or more, more preferably 800 m 3 /g or more, and still more preferably 1000 m 3 /g or more. 
     In the Fe oxide particles of the catalyst contained in the reaction composition, the Fe oxide is not particularly limited, but preferably contains Fe 2 O 3  as a main component. 
     The base contained in the reaction composition is not particularly limited as long as the base has a basicity stronger than at least one of the aromatic amines having one or more amino groups obtained as the product by hydrogenation reaction, and, in the state of being mixed with the Pt particles and the Fe oxide particles, has stability such that the chemical reaction dese not proceed with these particles at normal temperature and normal pressure. Any of inorganic base and organic base can be used. Further, the base can be properly used in consideration of the combination with the reactant and the solvent in the reaction system to be used. From the viewpoint of availability and the like, preferable examples of the base include sodium carbonate, sodium bicarbonate, potassium carbonate, triethylamine, sodium acetate. 
     The reaction composition may previously contain the aromatic nitro compound of the reactant. 
     Further, in this case, the reaction composition may further contain the aromatic amine obtained by the hydrogenation reaction of the aromatic nitro compound as a reaction product and having at least one amino group. 
     The “aromatic amine having one or more amino groups” desirably is the aromatic halogen amine as the main product, but within the range where the effect of the present invention can be obtained (within the range being allowable in the reaction system to be used), a case where an aromatic amine which is a dehalogenated body is slightly contained may be allowable. 
     The content of the base contained in the reaction composition may be set to an optimum value in the reaction system and reaction conditions where the reaction composition is used. 
     However, as mentioned above, from the viewpoint of obtaining the effect of the present invention more reliably, in the reaction composition, it is preferable that the base and a component of a solvent used in the hydrogenation reaction satisfy the condition of the following equation (1): 
       0.90≤{1000×( B/Vs )}≤190.00  (1)
 
     in the equation (1), B being a substance amount (mol) of the base, and Vs being a volume (L) of the organic solvent. 
     Further, from the viewpoint of obtaining the effect of the present invention more reliably, in the reaction composition, it is preferable that the base and the reactant used in the hydrogenation reaction satisfy the condition of the following equation (2): 
       0.35%≤{100×( B/R )}≤75.50%  (2)
 
     in the equation (2), B being a substance amount (mol) of the base, and R being a substance amount (mol) of the reactant. 
     Further, from the viewpoint of obtaining the effect of the present invention more reliably, in the reaction composition, it is preferable that a component of a solvent used in the hydrogenation reaction satisfies the condition of the following equation (3): 
       0.00%≤{100×( Vh/Vs )}≤30.00%  (3)
 
     in the equation (3), Vh being a volume (L) of an introduced water other than the yielded water, and Vs being a volume (L) of the organic solvent. 
     Furthermore, from the same viewpoint, in this case, it is more preferable that the water satisfies the condition of the following equation (4): 
       1.00%≤{100×( Vh/Vs )}≤5.00%  (4)
 
     Further, the reaction composition may further contain the dehydrating agent. 
     The dehydrating agent is not particularly limited as long as, in the state of being mixed with the Pt particles, the Fe oxide particles and the base, the agent has stability such that the chemical reaction does not proceed with these substances at normal temperature and normal pressure. From the viewpoint of availability and the like, preferable examples of the dehydrating agent include zeolite, sodium sulfate, magnesium sulfate. 
     The solvent contained in the reaction composition is not particularly limited as long as the solvent has chemical properties capable of dissolving at least a part of the reactant (aromatic halogen nitro compound). Preferred examples include toluene, xylene, benzene, chlorobenzene, dichlorobenzene, and an alcohol having 1 to 3 carbon atoms. A mixture thereof at an optional ratio may be used. 
     The reactant (aromatic halogen nitro compound) in the reaction system where the reaction composition is used is not particularly limited, and it is preferable that the reactant has the structure represented by the following general formula (C1): 
     
       
         
         
             
             
         
       
     
     In the formula (C1), 
     n represents an integer of 1 or more, 
     m represents an integer of 1 or more, 
     α represents an integer of 0 or more, 
     β represents an integer of 0 or more, and 
     5≤(n+m+α+β)≤6, 
     R represents hydrogen atom, amino group, hydroxyl group or a mono-valent or more-valent organic group having at least one carbon atom, 
     X represents any one of halogen atoms, 
     Y represents, in the case of α=1, an atom of C, N, O, or S, and, in the case of α≥2, at least two atoms selected from the group consisting of C, N, O and S, 
     Z represents, in the case of β=1, an atom of C, N, O, or S, and, in the case of β≥2, at least two atoms selected from the group consisting of C, N, O and S, and 
     Y and Z may be the same or different from each other. 
     Here, when α is 2 or more, R may be a divalent organic group bonded to two adjacent Y atoms. In this case, the aromatic nitro compound may have a structure of a condensed ring compound. 
     In addition, R which is an organic group having mono- or more-valence, may have a structure in which the moiety bonding to Yα is represented by “—O—” or “—S—”. 
     For example, in the formula (C1), in the case of α=2, Y 1 =C, Y 2 =N, R=H, β=2, Z 1 =C, Z 2 =C, m=1, X=Br, n=1, (n+m+α+β)=6, (C1) is 2-bromo-5-nitropyridine represented by the following formula (C1-1). 
     
       
         
         
             
             
         
       
     
     The reactant (aromatic halogen nitro compound) in the reaction system where the reaction composition is used may have the structure represented by the following general formula (C2): 
     
       
         
         
             
             
         
       
     
     In the formula (C2), 
     n represents an integer of 1 or more, 
     m represents an integer of 1 or more, 
     α represents an integer of 0 or more, 
     β represents an integer of 0 or more, and 
     5≤(n+m+α+β)≤6, 
     R represents hydrogen atom, amino group, hydroxyl group or a mono-valent or more-valent organic group having at least one carbon atom, 
     X represents any one of halogen atoms, 
     Y represents, in the case of α=1, an atom of C, N, O, or S, and, in the case of α≥2, at least two atoms selected from the group consisting of C, N, O and S, 
     Z represents, in the case of β=1, an atom of C, N, O, or S, and, in the case of β≥2, at least two atoms selected from the group consisting of C, N, O and S, 
     Y and Z may be the same or different from each other, and 
     J represents a divalent organic group having one or more carbon atoms, and in the case of m≥2, J may be the same or different from each other. 
     In addition, R which is an organic group having mono- or more-valence, may have a structure in which the moiety bonding to Yα is represented by “—O—” or “—S—”. 
     For example, in the formula (C2), the moiety represented by the “X-J-” may have the following structures represented by the formulae (C2-1), (C2-2), (C2-3) and (C2-4). 
     
       
         
         
             
             
         
       
     
     In the formula (C2-4), X 1  and X 2  each represent any one of halogen atoms, and X 1  and X 2  may be the same or different from each other. 
     &lt;Preparation Process of Reaction Composition&gt; 
     The preparation process of the reaction composition is not particularly limited, and any combination of known processes can be employed. 
     As the catalyst contained in the reaction composition, for example, a catalyst where the Pt particles and the Fe oxide particles are supported on the support may be obtained by subjecting a dispersion containing a Pt compound, a Fe compound and water to reduction treatment to the support. The supporting of Pt and the supporting of Fe oxide may be carried out at the same time as described above, or one may be carried out first and then the other may be later. 
     When mixing the catalyst, the base and the organic solvent, considering chemical properties of each component, the mixing order thereof is not particularly limited as long as these components can sufficiently mix without causing any undesired chemical reaction. 
     Further, when mixing the catalyst, the base, the organic solvent and the dehydrating agent, the mixing order thereof is not particularly limited as long as these components can sufficiently mix without causing any undesired chemical reaction. 
     When containing the reactant previously in the reaction composition, the mixing order is not particularly limited as long as the reactant can be sufficiently mixed without causing any undesired chemical reaction with other constituents. 
     The reaction composition of the present embodiment may be accommodated so as to be storable in a package such as a container or a bag after preparation. The internal structure of the package in contact with the reaction composition should be configured so as not to cause any chemical reaction with the reaction composition. When accommodating the reaction composition in the reaction composition packaging body, it is possible to easily move the reaction composition from the preparation place to the use place when the production place and the use place of the reaction composition are different. 
     Next, the preferred embodiments of the reaction system of the present invention are explained. 
     The reaction system of the present embodiment has a configuration which includes a reaction vessel which can accommodate the reaction composition of the present invention as the reactant. 
     The reaction system of the present embodiment may have a configuration including a reaction vessel capable of accommodating the reaction composition of the present invention as the reactant, and the other configuration is not particularly limited. As the configuration of the reaction system of the present embodiment, there can be employed the configurations which are the same as those of the known reaction system used for the hydrogenation reaction of at least one among one or more nitro groups present in a reactant to an amino group, the reactant being an aromatic nitro compound (aromatic halogen nitro compound) having a structure in which one or more nitro groups and one or more halogen atoms are directly bonded as substituents to a ring skeleton of the same ring while separated from each other. 
     In the reaction system of the present embodiment, the reaction composition of the present invention may be previously included as the constituent element. In this case, in the reaction system, the reaction composition of the present invention may be included in the reaction vessel previously, or may be previously accommodated and maintained in a container which is other than the reaction vessel, and when the reaction is carried out, the reaction composition may be transported from the other container to the reaction vessel. 
     Furthermore, the reaction system of this embodiment may have the configuration where the system further includes the other container which previously accommodates and maintains the constituent elements of the reaction composition of the present invention, before carrying out the hydrogenation reaction at the place where the hydrogenation reaction is carried out, and the constituent elements of the reaction composition are introduced into a predetermined container to prepare the reaction composition, and them the prepared reaction composition is used for the hydrogenation reaction. 
     In this case, the reaction system may have the other containers which can previously accommodate and maintain each of the constituent elements of the reaction composition of the present invention, or may have the other container which can previously accommodate and maintain a part of the constituent elements of the reaction composition of the present invention. For example, the reaction system may further have the other container that can previously accommodate and maintain the base and the organic solvent respectively, and the catalyst may be brought into from the other manufacturing place of the catalyst. 
     According to the reaction system of the present embodiment, since the reaction composition of the present invention is used, it is possible to realize the hydrogenation reaction where the nitro group of the aromatic nitro compound of the reactant can be selectively hydrogenated, and the removal of the halogen atoms from the ring can be sufficiently reduced. 
    
    
     EXAMPLE 
     In the following, the present invention is explained in detail by referring working examples, but the present invention is not limited by the following working examples. 
     Preparation of Reaction Composition 
     Example 1 
     As the catalyst, a catalyst where the Pt particles and the Fe oxide particles were carried on a carbon support {trade name “NE-01M02”, content of Pt: 1.0 wt %, content of Fe: 0.20 wt % available from N. E. CHEMCAT Co. (hereinafter referred to as “Pt-FeOx/C” as necessary)} was prepared. 
     In the Pt-FeOx/C, the carbon support is an activated carbon (specific surface area based on BET measurement is 900: m 2 /g), and the Fe oxide particles are Fe 2 O 3  as a main component (Fe 2 O 3  is approximately 100% based on XPS analysis). 
     As the base, a commercially available Na 2 CO 3  was prepared. 
     As the organic solvent, a commercially available toluene was prepared. 
     A reaction composition was obtained by mixing 127.0 mg (water content: 0.141 mL) of Pt-FeOx/C powder, 1.0 mg of Na 2 CO 3 , and 10 mL of toluene (organic solvent). 
     (Example 2) to (Example 5) 
     The reaction compositions of Example 2 to Example 5 were prepared in the same preparation conditions and the same raw materials as Example 1 except that the amount of Na 2 CO 3  was changed to the value shown in Table 1. 
     Example 6 
     The reaction composition of Example 6 was prepared in the same preparation conditions and the same raw materials as in Example 1 except that 20 mg of a commercially available K 2 CO 3  was used instead of the amount of Na 2 CO 3 . 
     Example 7 
     The reaction composition of Example 7 was prepared in the same preparation conditions and the same raw materials as in Example 1 except that 72.6 mg of a commercially available (CH 3 CH 2 ) 3 N was used instead of the amount of Na 2 CO 3 . 
     (Example 8) to (Example 14) 
     The catalyst mixtures of Example 8 to Example 14 were prepared in the same preparation conditions and the same raw materials as Example 3 except that the volume Vh (mL) of water was changed to the value shown in Table 1. 
     Comparative Example 1 
     As the reaction composition of Comparative Example 1, the catalyst of the powder of Pt-FeOx/C which was the same as that in Example 1 and the organic solvent were prepared without using a base. 
     Comparative Example 2 
     The reaction composition of Comparative Example 2 was prepared in the same preparation conditions and the same raw materials as in Comparative Example 1 except that 200 mg of a commercially available NaCl was used without using a base. 
     Comparative Example 3 
     The reaction composition of Comparative Example 3 was prepared in the same preparation conditions and the same raw materials as in Comparative Example 2 except that 30 mg of a commercially available Na 2 SO 4  was used without using a base. 
     Comparative Example 4 
     Instead of the Pt-FeOx/C used in Example 1, as the catalyst, a catalyst where the Pt particles were carried on a carbon support {trade name “NE-01M00”, content of Pt: 1.0 wt %, available from N. E. CHEMCAT Co. (hereinafter referred to as “Pt/C” as necessary)} was prepared. 
     In the Pt/C, the carbon support is an activated carbon (specific surface area based on BET measurement is 900: m 2 /g). 
     As the base, a commercially available Na 2 CO 3  was prepared. 
     A reaction composition was obtained by mixing 127.0 mg (water content: 0.113 mL) of Pt/C powder and 10.0 mg of Na 2 CO 3  and 10 mL of toluene (organic solvent). 
     Comparative Example 5 
     The reaction composition of Comparative Example 2 was prepared in the same preparation conditions and the same raw materials as Comparative Example 1 except that the amount of Na 2 CO 3  was changed to the value shown in Table 1. 
     (Comparative Example 6) to (Comparative Example 8) 
     The reaction compositions of Comparative Example 6 to Comparative Example 8 were prepared in the same preparation conditions and the same raw materials as Comparative Example 1 except that the amount of the Pt/C powder to be used was changed to 140.0 mg (water content: 0.123 mL) and water was added under the following conditions. The amount of water added to the reaction composition of Comparative Example 6 was adjusted to 0.444 mL, and the amount of water added to the reaction compositions of Comparative Example 7 and Comparative Example 8 were adjusted to be 1.000 mL. 
     Comparative Example 9 
     As the reaction composition of Comparative Example 9, the catalyst of the powder of Pt/C which was the same as that in Comparative Example 1 and the organic solvent were prepared without using a base. 
     &lt;Hydrogenation Reaction&gt; 
     The hydrogenation reaction (hydrogenation reaction of nitro group) represented by the following reaction scheme (C1-11) was achieved by using the reaction compositions of Example 1 to Example 7 and Comparative Example 1 to Comparative Example 9. 
     
       
         
         
             
             
         
       
     
     Here, in the hydrogenation reaction represented by the reaction scheme (C1-11), 2-bromo-5-nitropyridine represented by the formula (C1-1) has a heterocyclic structure having an N atom. Compared to 2-bromo-5-nitrobenzene which has a structure in which the N atom in this heterocyclic ring is replaced with a C atom, 2-bromo-5-nitropyridine is a reactant which promotes not only the main hydrogenation reaction of the nitro group (main product being 5-amino-2-bromopyridine represented by the formula (C1-2)), but also promotes easily the side reaction of the debromination reaction (by-product being 3-aminopyridine represented by the formula (C1-3). 
     (Reaction Conditions) 
     Reactant: 2.5 mmol of 2-Bromo-5-nitrobenzene represented by the formula (C1-1) 
     Pressure of hydrogen: 0.6 MPa 
     Reaction temperature: 50° C. 
     Reaction time: 5 hours 
     The results obtained for the reaction compositions of Examples 1 to 14 and Comparative Examples 1 to 9 are shown in Table 1 and Table 2. The formula weight of Na 2 CO 3  was 106 g·mol, the formula weight of K 2 CO 3  was 138.2 g·mol, and the formula weight of (CH 3 CH 2 ) 3 N was 101 g·mol. 
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
             
               
                   
                 TABLE 1 
               
               
                   
                   
               
               
                   
                   
                   
                   
                 B 
                   
                   
                 R 
                   
                   
                   
               
               
                   
                   
                   
                   
                 Base 
                 Vs 
                   
                 Reactant 
                   
                 Vh 
               
               
                   
                   
                 Base 
                 Base 
                 Substace 
                 Org. Solvent 
                 100x 
                 Substace 
                 100x 
                 Water 
                 100x 
               
               
                   
                 Catalyst 
                 (other 
                 Mass/ 
                 amount/ 
                 (Toluen) 
                 (B/Vs)/ 
                 amount/ 
                 (B/R)/ 
                 volume/ 
                 (Vh/Vs) 
               
               
                   
                 structure 
                 additives) 
                 mg 
                 mmol 
                 volume/mL 
                 mol L −1   
                 mmol 
                 mol L −1   
                 mL 
                 % 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 Ex. 1 
                 Pt—FeO x /C 
                 Na 2 CO 3   
                 1.0 
                 0.0094 
                 10.0 
                 0.94 
                 2.50 
                 0.38 
                 0.141 
                 1.41 
               
               
                 Ex. 2 
                 Pt—FeO x /C 
                 Na 2 CO 3   
                 5.0 
                 0.0472 
                 10.0 
                 4.72 
                 2.50 
                 1.89 
                 0.141 
                 1.41 
               
               
                 Ex. 3 
                 Pt—FeO x /C 
                 Na 2 CO 3   
                 10.0 
                 0.0943 
                 10.0 
                 9.43 
                 2.50 
                 3.77 
                 0.141 
                 1.41 
               
               
                 Ex. 4 
                 Pt—FeO x /C 
                 Na 2 CO 3   
                 20.0 
                 0.1887 
                 10.0 
                 18.87 
                 2.50 
                 7.55 
                 0.141 
                 1.41 
               
               
                 Ex. 5 
                 Pt—FeO x /C 
                 Na 2 CO 3   
                 200.0 
                 1.8868 
                 10.0 
                 188.68 
                 2.50 
                 75.47 
                 0.141 
                 1.41 
               
               
                 Ex. 6 
                 Pt—FeO x /C 
                 K 2 CO 3   
                 20.0 
                 0.1447 
                 10.0 
                 14.47 
                 2.50 
                 5.79 
                 0.141 
                 1.41 
               
               
                 Ex. 7 
                 Pt—FeO x /C 
                 (CH 3 CH 3 ) 3 N 
                 72.6 
                 0.7188 
                 10.0 
                 71.88 
                 2.50 
                 23.75 
                 0.141 
                 1.41 
               
               
                 Ex. 8 
                 Pt—FeO x /C 
                 Na 2 CO 3   
                 10.0 
                 0.0943 
                 10.0 
                 9.43 
                 2.50 
                 3.77 
                 0.460 
                 4.60 
               
               
                 Ex. 9 
                 Pt—FeO x /C 
                 Na 2 CO 3   
                 10.0 
                 0.0943 
                 10.0 
                 9.43 
                 2.50 
                 3.77 
                 1.136 
                 11.36 
               
               
                 Ex. 10 
                 Pt—FeO x /C 
                 Na 2 CO 3   
                 10.0 
                 0.0943 
                 10.0 
                 9.43 
                 2.50 
                 3.77 
                 2.000 
                 20.00 
               
               
                 Ex. 11 
                 Pt—FeO x /C 
                 Na 2 CO 3   
                 10.0 
                 0.0943 
                 10.0 
                 9.43 
                 2.50 
                 3.77 
                 2.200 
                 22.00 
               
               
                 Ex. 12 
                 Pt—FeO x /C 
                 Na 2 CO 3   
                 10.0 
                 0.0943 
                 10.0 
                 9.43 
                 2.50 
                 3.77 
                 2.800 
                 28.00 
               
               
                 Ex. 13 
                 Pt—FeO x /C 
                 Na 2 CO 3   
                 10.0 
                 0.1048 
                 9.0 
                 10.48 
                 2.50 
                 3.77 
                 1.620 
                 18.00 
               
               
                 Ex. 14 
                 Pt—FeO x /C 
                 Na 2 CO 3   
                 10.0 
                 0.1048 
                 9.0 
                 10.48 
                 2.50 
                 3.77 
                 1.800 
                 20.00 
               
               
                 Com. Ex. 1 
                 Pt—FeO x /C 
                 Non 
                 0.0 
                 0.0000 
                 10.0 
                 0.00 
                 2.50 
                 0.00 
                 0.141 
                 1.41 
               
               
                 Com. Ex. 2 
                 Pt—FeO x /C 
                 Non 
                 0.0 
                 0.0000 
                 10.0 
                 0.00 
                 2.50 
                 0.00 
                 0.141 
                 1.41 
               
               
                   
                   
                 (NaCl) 
               
               
                 Com. Ex. 3 
                 Pt—FeO x /C 
                 Non 
                 0.0 
                 0.0000 
                 10.0 
                 0.00 
                 2.50 
                 0.00 
                 0.141 
                 1.41 
               
               
                   
                   
                 (Na 2 SO 4 ) 
               
               
                 Com. Ex. 4 
                 Pt/C 
                 Na 2 CO 3   
                 10.0 
                 0.0943 
                 10.0 
                 9.43 
                 2.50 
                 3.77 
                 0.113 
                 1.13 
               
               
                 Com. Ex. 5 
                 Pt/C 
                 Na 2 CO 3   
                 5.0 
                 0.0472 
                 10.0 
                 4.72 
                 2.50 
                 1.89 
                 0.113 
                 1.13 
               
               
                 Com. Ex. 6 
                 Pt/C 
                 Na 2 CO 3   
                 10.0 
                 0.0943 
                 10.0 
                 9.43 
                 2.50 
                 3.77 
                 0.567 
                 5.67 
               
               
                 Com. Ex. 7 
                 Pt/C 
                 Na 2 CO 3   
                 10.0 
                 0.0943 
                 10.0 
                 9.43 
                 2.50 
                 3.77 
                 1.123 
                 11.23 
               
               
                 Com. Ex. 8 
                 Pt/C 
                 Na 2 CO 3   
                 10.0 
                 0.0943 
                 10.0 
                 9.43 
                 2.50 
                 3.77 
                 1.123 
                 11.23 
               
               
                 Com. Ex. 9 
                 Pt/C 
                 Non 
                 0.0 
                 0.0000 
                 10.0 
                 0.00 
                 2.50 
                 0.00 
                 0.113 
                 1.13 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 2 
               
               
                   
                   
               
               
                   
                   
                 Selectivity % 
                 Selectivity % 
               
               
                   
                   
                 5-amino-2- 
                 3-aminopyridine 
               
               
                   
                 Conversion 
                 bromopyridine 
                 by-product 
               
               
                   
                 % 
                 main product 
                 (DeBr body) 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 Ex. 1 
                 100 
                 90.8 
                 9.2 
               
               
                 Ex. 2 
                 100 
                 98.1 
                 1.9 
               
               
                 Ex. 3 
                 100 
                 99.5 
                 0.5 
               
               
                 Ex. 4 
                 100 
                 99.7 
                 0.3 
               
               
                 Ex. 5 
                 100 
                 99.6 
                 0.4 
               
               
                 Ex. 6 
                 100 
                 99.6 
                 0.4 
               
               
                 Ex. 7 
                 100 
                 98.2 
                 1.8 
               
               
                 Ex. 8 
                 100 
                 98.4 
                 1.6 
               
               
                 Ex. 9 
                 100 
                 96.0 
                 4.0 
               
               
                 Ex. 10 
                 100 
                 92.8 
                 7.2 
               
               
                 Ex. 11 
                 100 
                 92.9 
                 7.1 
               
               
                 Ex. 12 
                 100 
                 91.3 
                 8.7 
               
               
                 Ex. 13 
                 100 
                 94.0 
                 6.0 
               
               
                 Ex. 14 
                 100 
                 92.8 
                 7.2 
               
               
                 Com. Ex. 1 
                 100 
                 81.5 
                 18.5 
               
               
                 Com. Ex. 2 
                 100 
                 79.5 
                 20.5 
               
               
                 Com. Ex. 3 
                 100 
                 84.5 
                 15.5 
               
               
                 Com. Ex. 4 
                 100 
                 84.7 
                 15.3 
               
               
                 Com. Ex. 5 
                 100 
                 72.4 
                 27.6 
               
               
                 Com. Ex. 6 
                 100 
                 82.9 
                 17.1 
               
               
                 Com. Ex. 7 
                 100 
                 66.5 
                 33.5 
               
               
                 Com. Ex. 8 
                 100 
                 42.1 
                 57.9 
               
               
                 Com. Ex. 9 
                 100 
                 48.9 
                 51.1 
               
               
                   
               
            
           
         
       
     
     From the results shown in Table 2, when the reaction system using the reaction compositions of Example 1 to Example 14 which satisfy the constitution of the present invention are compared with the reaction system using the reaction compositions of Comparative Example 1 to Comparative Example 9, it has been clear that the debromination reaction to 3-aminopyridine represented by the formula (C1-3) was sufficiently reduced, and the selectivity of the desired 5-amino-2-bromopyridine represented by the formula (C1-2) was improved. 
     In particular, when the reaction system using the reaction compositions of Example 1 to Example 14 which satisfy the constitution of the present invention are compared with the reaction system using the reaction composition of Comparative Example 1 which has the structure similar to that of Patent Document 3 described as a prior art document (reaction system which has a catalyst containing a Pt component and an iron oxide component, an organic solvent (structure where the reactant is used as the organic solvent), and does not contain a base), it has been clear that the debromination reaction to 3-aminopyridine represented by the formula (C1-3) was sufficiently reduced. 
     Further, when the reaction system using the reaction compositions of Example 1 to Example 14 which satisfy the constitution of the present invention are compared with the reaction system using the reaction composition of Comparative Example 6 which has the structure similar to that of Patent Document 4 described as a prior art document (reaction system which has a catalyst containing a Pt component, an organic solvent and a base, and water is added (in Example 4 of Patent Document 4, 100×(Vh/Vs)=100×(amount of added water 30 mL+water contained in the catalyst 1.5 mL)/toluene 675 mL=4.6%), it has been clear that the debromination reaction to 3-aminopyridine represented by the formula (C1-3) was sufficiently reduced. 
     From the aforementioned results, it has been clear that, in a nitro group hydrogenation reaction of an aromatic nitro compound having a structure in which nitro groups and halogen atoms are directly bonded as substituents to a ring skeleton of the same ring while separated from each other, the reaction composition of the present examples is capable of selectively hydrogenating the nitro groups and sufficiently reducing the removal of the halogen atoms from the ring. 
     INDUSTRIAL APPLICABILITY 
     The reaction composition of the present invention has the catalyst activities that, in a nitro group hydrogenation reaction of an aromatic nitro compound (aromatic halogen nitro compound) having a structure in which nitro groups and halogen atoms are directly bonded as substituents to a ring skeleton of the same ring while separated from each other, is capable of selectively hydrogenating the nitro groups and sufficiently reducing the removal of the halogen atoms from the ring. 
     Therefore, the present invention contributes to the development of efficient mass production technology of the aromatic halogen amine which is an important raw material of medicines, dyes, insecticides and herbicides, and further contributes to the development of the industries of pharmaceuticals, dyes, insecticides, herbicides.