Patent Publication Number: US-2021178040-A1

Title: Extracorporeal circulation management device, extracorporeal circulation device, and extracorporeal circulation management program

Description:
CROSS REFERENCE TO RELATED APPLICATIONS 
     This application is a continuation of PCT Application No. PCT/JP2019/033967, filed Aug. 29, 2019, based on and claiming priority to Japanese Application No. 2018-167079, filed Sep. 6, 2018, both of which are incorporated herein by reference in their entirety. 
    
    
     BACKGROUND OF THE INVENTION 
     The present invention relates to an extracorporeal circulation management device, an extracorporeal circulation device, and an extracorporeal circulation management program. 
     For example, when it is necessary to supply blood to a patient during a surgery, extracorporeal circulation is performed in which the patient&#39;s blood is circulated extracorporeally using an extracorporeal circulation device having an artificial heart-lung device or the like. In addition, there are various auxiliary circulation methods, such as veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and veno-venous extracorporeal membrane oxygenation (VV-ECMO), as long-term life support by extracorporeal circulation of blood. 
     For example, in auxiliary circulation techniques using VV-ECMO, extracorporeal circulation has been increasingly performed for a long period of time. Therefore, it becomes important not only to manage a state of a patient but also to grasp states of devices such as circulation circuits, pumps, and oxygenators, used for extracorporeal circulation such that extracorporeal circulation can be appropriately performed. 
     In addition, use of devices, such as pressure sensors and flow rate sensors, extracorporeal circulation has increased. Accordingly, the number of items to be monitored in the auxiliary circulation techniques has increased. Therefore, it is required to understand the significance of values measured by the respective devices and to appropriately comprehend the values measured by the respective devices in the medical field. For example, it is important to pay attention to a distribution and a state of a pressure applied in a circulation circuit in the medical field. If a blood removal pressure (for example, a negative pressure) increases when a flow rate of blood flowing through the circulation circuit decreases, blood removal failure is suspected in the medical field based on a rule of thumb invoked by a device operator or the like. Further, the operator or the like inspects the circulation circuit to identify a cause of the blood removal failure in a circuit or device on the blood removal side, and resolves the blood removal failure. 
     Published Japanese patent application JP2017-38805A discloses an extracorporeal circulation management device that displays state information of a pressure sensor, a flow rate sensor, and the like on a display unit as continuous state information over time, and displays warning information on the display unit based on trend information of the continuous state information over time. In the extracorporeal circulation management device described in JP2017-38805A, however, there is room for improvement in that it may be difficult for an operator to easily recognize a cause of circulation failure in extracorporeal circulation although the continuous state information over time and the warning information are displayed on the display unit. 
     SUMMARY OF THE INVENTION 
     The present invention has been made to solve the above problem, and an object thereof is to provide an extracorporeal circulation management device, an extracorporeal circulation device, and an extracorporeal circulation management program that allow an operator or like to easily recognize a cause and/or location of circulation failure in extracorporeal circulation. 
     According to the present invention, the above problem is solved by an extracorporeal circulation management device that manages an extracorporeal circulation device which extracorporeally circulates blood using a circulation circuit, the extracorporeal circulation management device displaying on a display unit an expected flow rate, which is assumed in advance (i.e., predicted using a model of nominal performance of the circulation device) as an expected value of a flow rate of the blood flowing inside the circulation circuit, and an actual flow rate. The actual flow rate is measured by a flow rate measurement unit as an actually measured value of the flow rate of the blood flowing inside the circulation circuit. The display unit also displays a standard pressure, which represents a relation between the blood flow rate and a pressure loss occurring in a device provided in the circulation circuit and is calculated based on the expected flow rate by referring to standard information stored in a storage unit, and an actual pressure related to the device, which is calculated based on an actual pressure measured by a pressure measurement unit as an actually measured value of a pressure of the blood flowing inside the circulation circuit and the actual flow rate, on the display unit. 
     According to the extracorporeal circulation management device of the present invention, the expected flow rate expected in advance as the expected value of the flow rate of the blood flowing inside the circulation circuit and the actual flow rate measured by the flow rate measurement unit as the actually measured value of the flow rate of the blood flowing inside the circulation circuit are displayed on the display unit. As a result, an operator and the like can easily grasp a discrepancy or deviation between the expected flow rate of the blood in the circulation circuit and the actual flow rate of the blood actually flowing through the circulation circuit by confirming the display unit. In addition, the standard pressure calculated based on the expected flow rate by referring to the standard information stored in the storage unit, which is the standard information representing the relation between the blood flow rate and the pressure loss occurring in the device provided in the circulation circuit under normal conditions, and the actual pressure related to the device, calculated based on the actual pressure measured by the pressure measurement unit as the actually measured value of the pressure of the blood flowing inside the circulation circuit and the actual flow rate measured by the flow rate measurement unit, are displayed on the display unit. As a result, the operator or the like can easily grasp a discrepancy or deviation between the standard pressure calculated based on the expected flow rate and the actual pressure related to the device by confirming the display unit. Therefore, when there is a discrepancy or deviation between the expected flow rate and the actual flow rate, the operator or the like can easily grasp the occurrence of the discrepancy or deviation between the expected flow rate and the actual flow rate and grasp a location of the circulation circuit where the discrepancy or deviation between the standard pressure and the actual pressure has occurred and easily grasp that a cause of circulation failure exists near the location by observing the display unit. That is, the location of the circulation circuit where the discrepancy or deviation between the standard pressure and the actual pressure has occurred corresponds to a portion where the pressure measurement unit is provided or a portion of the device provided near the pressure measurement unit. In this manner, the operator or the like can easily grasp the cause of the circulation failure in the extracorporeal circulation. 
     Preferably, the extracorporeal circulation management device according to the present invention further displays a differential flow rate representing a difference between the expected flow rate and the actual flow rate and a differential pressure representing a difference between the standard pressure and the actual pressure related to the device on the display unit. 
     According to the extracorporeal circulation management device of the present invention, the differential flow rate representing the difference between the expected flow rate and the actual flow rate and the differential pressure representing the difference between the standard pressure and the actual pressure related to the device are further displayed on the display unit. As a result, the operator or the like can more easily grasp a discrepancy or deviation between the expected flow rate and the actual flow rate and a discrepancy or deviation between the standard pressure and the actual pressure by confirming the display unit. The standard pressure is calculated based on the standard information stored in the storage unit and the expected flow rate. That is, the standard pressure changes depending on the expected flow rate. Therefore, a discrepancy or deviation sometimes occurs between the standard pressure and the actual pressure even if the actual pressure related to the device does not change at first glance. On the other hand, the operator or the like can more easily grasp the discrepancy or deviation between the standard pressure and the actual pressure by observing the display unit according to the extracorporeal circulation management device of the present invention. 
     Preferably, in the extracorporeal circulation management device according to the present invention, the device includes a plurality of instrument elements interconnected in the circulation circuit, and the pressure measurement unit includes a plurality of pressure sensors. A plurality of the standard pressures calculated based on the expected flow rate by referring to a plurality of pieces of the standard information each representing a relation between the blood flow rate and the pressure loss occurring in each of the plurality of instrument elements and stored in the storage unit, and the actual pressures related to the plurality of instrument elements, are calculated based on a plurality of the actual pressures measured by the plurality of pressure sensors and the actual flow rate, and then displayed on the display unit. A plurality of the differential pressures each representing a difference between each one of the plurality of standard pressures and each one of the actual pressures related to the plurality of instrument elements are displayed on the display unit. 
     According to the extracorporeal circulation management device of the present invention, the plurality of standard pressures calculated based on the expected flow rate by referring to the plurality of pieces of standard information stored in the storage unit (which are the plurality of pieces of standard information each representing the relation between the blood flow rate and the pressure loss occurring in each of the plurality of instrument elements) and the actual pressures related to the plurality of instrument elements are calculated based on the plurality of actual pressures measured by the plurality of pressure sensors and the actual flow rate measured by the flow rate measurement unit, and then displayed on the display unit. In addition, the plurality of differential pressures each representing the difference between each of the plurality of standard pressures and each of the actual pressures related to the plurality of instrument elements are displayed on the display unit, respectively. Therefore, the operator or the like can more easily grasp a discrepancy or deviation between each of the plurality of standard pressures and each of the actual pressures related to the plurality of instrument elements, and can more easily grasp a location in the circulation circuit where the discrepancy or deviation between the standard pressure and the actual pressure has occurred from among a plurality of locations and easily grasp that a cause of circulation failure exists near the location by observation of the display unit. That is, the location of the circulation circuit where the discrepancy or deviation between the standard pressure and the actual pressure has occurred corresponds to a portion where a pressure sensor detects an abnormal value among the plurality of pressure sensors is located or a portion of an instrument element provided near the pressure sensor detecting the abnormal value among the plurality of instrument elements is located. 
     Preferably, in the extracorporeal circulation management device according to the present invention, the plurality of instrument elements include: a blood removing catheter which is partially inserted into a patient and which guides the blood taken out from the patient; a pump which is provided on a downstream side of the blood removing catheter and which takes out the blood from the patient through the blood removing catheter and sends the blood to the downstream side; an oxygenator which is provided on the downstream side of the pump and performs a gas exchange operation for the blood; and a blood feeding catheter which is provided on the downstream side of the oxygenator and is partially inserted into the patient and which guides the blood that has passed through the oxygenator to the patient. A plurality of pressure sensors include: a first pressure sensor provided in the circulation circuit at least between the blood removing catheter and the pump or between the pump and the oxygenator; and a second pressure sensor provided in the circulation circuit between the oxygenator and the blood feeding catheter. A flow rate measurement unit is a flow rate sensor provided in the circulation circuit. All the 1) expected flow rate, the actual flow rate acquired by the flow rate sensor, 2) the differential flow rate, 3) the standard pressure related to the blood removing catheter calculated based on the expected flow rate by referring to the standard information related to the blood removing catheter, which represents a relation between the blood flow rate and the pressure loss occurring in the blood removing catheter and is stored in the storage unit, 4) the standard pressure related to the oxygenator calculated based on the expected flow rate by referring to the standard information related to the oxygenator, which represents a relation between the blood flow rate and the pressure loss occurring in the oxygenator and is stored in the storage unit, 5) the standard pressure related to the blood feeding catheter calculated based on the expected flow rate by referring to the standard information related to the blood feeding catheter, which represents a relation between the blood flow rate and the pressure loss occurring in the blood feeding catheter and is stored in the storage unit, 6) the actual pressure related to the blood removing catheter calculated based on the actual pressure measured by the first pressure sensor and the actual flow rate, 7) the actual pressure related to the oxygenator calculated based on the actual pressure measured by the first pressure sensor, the actual pressure measured by the second pressure sensor, and the actual flow rate, 8) the actual pressure related to the blood feeding catheter calculated based on the actual pressure measured by the second pressure sensor and the actual flow rate, the differential pressure related to the blood removing catheter which represents a difference between the standard pressure related to the blood removing catheter and the actual pressure related to the blood removing catheter, 9) the differential pressure related to the oxygenator which represents a difference between the standard pressure related to the oxygenator and the actual pressure related to the oxygenator, and 10) the differential pressure related to the blood feeding catheter which represents a difference between the standard pressure related to the blood feeding catheter and the actual pressure related to the blood feeding catheter are simultaneously displayed on the display unit. 
     According to the extracorporeal circulation management device of the present invention, the standard pressure related to the blood removing catheter calculated based on the expected flow rate by referring to the standard information related to the blood removing catheter stored in the storage unit, which is the standard information related to the blood removing catheter representing the relation between the blood flow rate and the pressure loss occurring in the blood removing catheter, is displayed on the display unit. In addition, the standard pressure related to the oxygenator calculated based on the expected flow rate by referring to the standard information related to the oxygenator stored in the storage unit, which is the standard information related to the oxygenator representing the relation between the blood flow rate and the pressure loss occurring in the oxygenator, is displayed on the display unit. In addition, the standard pressure related to the blood feeding catheter calculated based on the expected flow rate by referring to the standard information related to the blood feeding catheter stored in the storage unit, which is the standard information related to the blood feeding catheter representing the relation between the blood flow rate and the pressure loss occurring in the blood feeding catheter, is displayed on the display unit. In addition, the actual pressure related to the blood removing catheter, calculated based on the actual pressure measured by the first pressure sensor and the actual flow rate acquired by the flow rate sensor, is displayed on the display unit. In addition, the actual pressure related to the oxygenator, calculated based on the actual pressure measured by the first pressure sensor, the actual pressure measured by the second pressure sensor, and the actual flow rate acquired by the flow rate sensor, is displayed on the display unit. In addition, the actual pressure related to the blood feeding catheter, calculated based on the actual pressure measured by the second pressure sensor and the actual flow rate acquired by the flow rate sensor, is displayed on the display unit. In addition, the differential pressure related to the blood removing catheter, which represents the difference between the standard pressure related to the blood removing catheter and the previous pressure related to the blood removing catheter, is displayed on the display unit. In addition, the differential pressure related to the oxygenator, which represents the difference between the standard pressure related to the oxygenator and the actual pressure related to the oxygenator, is displayed on the display unit. In addition, the differential pressure related to the blood feeding catheter, which represents the difference between the standard pressure related to the blood feeding catheter and the actual pressure related to the blood feeding catheter, is displayed on the display unit. Further, all the expected flow rate, the actual flow rate, the differential flow rate, the standard pressure related to the blood removing catheter, the standard pressure related to the oxygenator, the standard pressure related to the blood feeding catheter, the actual pressure related to the blood removing catheter, the actual pressure related to the oxygenator, the actual pressure related to the blood feeding catheter, the differential pressure related to the blood removing catheter, the differential pressure related to the oxygenator, and the differential pressure related to the blood feeding catheter are simultaneously displayed on the display unit. As a result, the operator or the like can easily grasp a discrepancy or deviation between the standard pressure and the actual pressure and more concretely and easily grasp a location of the circulation circuit where the discrepancy or deviation between the standard pressure and the actual pressure has occurred and easily grasp that a cause of circulation failure exists near the location by observing the display unit. That is, the location of the circulation circuit where the discrepancy or deviation between the standard pressure and the actual pressure has occurred corresponds to a portion where a pressure sensor detecting an abnormal value between the first pressure sensor and the second pressure sensor is provided or a portion of an instrument element provided near the pressure sensor detecting the abnormal value among the blood removing catheter, the oxygenator, and the blood feeding catheter. 
     Preferably, in the extracorporeal circulation management device according to the present invention, the plurality of instrument elements interconnected in a circulation circuit include: a blood removing catheter which is partially inserted into a patient and guides the blood taken out from the patient; a pump which is provided on a downstream side of the blood removing catheter, takes out the blood from the patient through the blood removing catheter, and sends the blood to the downstream side; an oxygenator which is provided on the downstream side of the pump and performs a gas exchange operation for the blood; and a blood feeding catheter which is provided on the downstream side of the oxygenator and is partially inserted into the patient, and which guides the blood that has passed through the oxygenator to the patient. A plurality of pressure sensors include: a first pressure sensor provided in the circulation circuit between the blood removing catheter and the pump; a second pressure sensor provided in the circulation circuit between the pump and the oxygenator; and a third pressure sensor provided in the circulation circuit between the oxygenator and the blood feeding catheter. The flow rate measurement unit is a flow rate sensor provided in the circulation circuit. All the expected flow rate, the actual flow rate acquired by the flow rate sensor, the differential flow rate, the standard pressure related to the blood removing catheter calculated based on the expected flow rate by referring to the standard information related to the blood removing catheter which represents a relation between the blood flow rate and the pressure loss occurring in the blood removing catheter and is stored in the storage unit, the standard pressure related to the oxygenator calculated based on the expected flow rate by referring to the standard information related to the oxygenator which represents a relation between the blood flow rate and the pressure loss occurring in the oxygenator and is stored in the storage unit, the standard pressure related to the blood feeding catheter calculated based on the expected flow rate by referring to the standard information related to the blood feeding catheter which represents a relation between the blood flow rate and the pressure loss occurring in the blood feeding catheter and is stored in the storage unit, the actual pressure related to the blood removing catheter calculated based on the actual pressure measured by the first pressure sensor and the actual flow rate, the actual pressure related to the oxygenator calculated based on the actual pressure measured by the second pressure sensor, the actual pressure measured by the third pressure sensor, and the actual flow rate, the actual pressure related to the blood feeding catheter calculated based on the actual pressure measured by the third pressure sensor and the actual flow rate, the differential pressure related to the blood removing catheter which represents a difference between the standard pressure related to the blood removing catheter and the actual pressure related to the blood removing catheter, the differential pressure related to the oxygenator which represents a difference between the standard pressure related to the oxygenator and the actual pressure related to the oxygenator, and the differential pressure related to the blood feeding catheter which represents a difference between the standard pressure related to the blood feeding catheter and the actual pressure related to the blood feeding catheter are simultaneously displayed on the display unit. 
     According to the extracorporeal circulation management device of the present invention, the standard pressure related to the blood removing catheter calculated based on the expected flow rate by referring to the standard information related to the blood removing catheter stored in the storage unit, which is the standard information related to the blood removing catheter representing the relation between the blood flow rate and the pressure loss occurring in the blood removing catheter, is displayed on the display unit. In addition, the standard pressure related to the oxygenator calculated based on the expected flow rate by referring to the standard information related to the oxygenator stored in the storage unit, which is the standard information related to the oxygenator representing the relation between the blood flow rate and the pressure loss occurring in the oxygenator, is displayed on the display unit. In addition, the standard pressure related to the blood feeding catheter calculated based on the expected flow rate by referring to the standard information related to the blood feeding catheter stored in the storage unit, which is the standard information related to the blood feeding catheter representing the relation between the blood flow rate and the pressure loss occurring in the blood feeding catheter, is displayed on the display unit. In addition, the actual pressure related to the blood removing catheter, calculated based on the actual pressure measured by the first pressure sensor and the actual flow rate acquired by the flow rate sensor, is displayed on the display unit. In addition, the actual pressure related to the oxygenator, calculated based on the actual pressure measured by the second pressure sensor, the actual pressure measured by the third pressure sensor, and the actual flow rate acquired by the flow rate sensor, is displayed on the display unit. In addition, the actual pressure related to the blood feeding catheter, calculated based on the actual pressure measured by the third pressure sensor and the actual flow rate acquired by the flow rate sensor, is displayed on the display unit. In addition, the differential pressure related to the blood removing catheter, which represents the difference between the standard pressure related to the blood removing catheter and the actual pressure related to the blood removing catheter, is displayed on the display unit. In addition, the differential pressure related to the oxygenator, which represents the difference between the standard pressure related to the oxygenator and the actual pressure related to the oxygenator, is displayed on the display unit. In addition, the differential pressure related to the blood feeding catheter, which represents the difference between the standard pressure related to the blood feeding catheter and the actual pressure related to the blood feeding catheter, is displayed on the display unit. Further, all the expected flow rate, the actual flow rate, the differential flow rate, the standard pressure related to the blood removing catheter, the standard pressure related to the oxygenator, the standard pressure related to the blood feeding catheter, the actual pressure related to the blood removing catheter, the actual pressure related to the oxygenator, the actual pressure related to the blood feeding catheter, the differential pressure related to the blood removing catheter, the differential pressure related to the oxygenator, and the differential pressure related to the blood feeding catheter are simultaneously displayed on the display unit. As a result, the operator or the like can easily grasp a discrepancy or deviation between the standard pressure and the actual pressure and more concretely and easily grasp a location of the circulation circuit where the discrepancy or deviation between the standard pressure and the actual pressure has occurred and easily grasp that a cause of circulation failure exists near the location by observing the display unit. That is, the location of the circulation circuit where the discrepancy or deviation between the standard pressure and the actual pressure has occurred corresponds to a portion where a pressure sensor detecting an abnormal value among the first pressure sensor, the second pressure sensor, and the third pressure sensor is provided or a portion of an instrument element provided near the pressure sensor detecting the abnormal value among the blood removing catheter, the oxygenator, and the blood feeding catheter. 
     Preferably, the extracorporeal circulation management device according to the present invention provides notification of a warning when an absolute value of at least one of the differential flow rate and the differential pressure exceeds a predetermined value. 
     According to the extracorporeal circulation management device of the present invention, the operator or the like can more easily grasp occurrence of a discrepancy or deviation between the expected flow rate and the actual flow rate and further grasp a location of the circulation circuit where the discrepancy or deviation between the standard pressure and the actual pressure has occurred and more easily grasp that a cause of circulation failure exists near the location. 
     According to the present invention, the above problem is solved by an extracorporeal circulation device which extracorporeally circulates blood using a circulation circuit, the extracorporeal circulation device including: a display unit that displays various types of information; a blood removing catheter which is partially inserted into a patient and guides the blood taken out from the patient; a pump which is provided on a downstream side of the blood removing catheter, takes out the blood from the patient through the blood removing catheter, and sends the blood to the downstream side; an oxygenator which is provided on the downstream side of the pump and performs a gas exchange operation for the blood; a blood feeding catheter which is provided on the downstream side of the oxygenator, is partially inserted into the patient, and guides the blood that has passed through the oxygenator to the patient; and any of the above-described extracorporeal circulation management devices. 
     According to the extracorporeal circulation device of the present invention, the assumed flow rate assumed (i.e., predicted using a model of nominal performance of the circulation device) in advance as the expected value of the flow rate of the blood flowing inside the circulation circuit and the actual flow rate measured by the flow rate measurement unit as the actually measured value of the flow rate of the blood flowing inside the circulation circuit are displayed on the display unit. As a result, an operator and the like can easily grasp a discrepancy or deviation between the expected flow rate of the blood in the circulation circuit and the actual flow rate of the blood actually flowing through the circulation circuit by confirming the display unit. In addition, the standard pressure calculated based on the expected flow rate by referring to the standard information stored in the storage unit, which is the standard information representing the relation between the blood flow rate and the pressure loss occurring in the device, such as the blood removing catheter, the pump, the oxygenator, and the blood feeding catheter, provided in the circulation circuit, and the actual pressure related to the device, calculated based on the actual pressure measured by the pressure measurement unit as the actually measured value of the pressure of the blood flowing inside the circulation circuit and the actual flow rate measured by the flow rate measurement unit, are displayed on the display unit. As a result, the operator or the like can easily grasp a discrepancy or deviation between the standard pressure calculated based on the expected flow rate and the actual pressure related to the device by observing the display unit. Therefore, when there is a discrepancy or deviation between the expected flow rate and the actual flow rate, the operator or the like can easily grasp the occurrence of the discrepancy or deviation between the expected flow rate and the actual flow rate and grasp a location of the circulation circuit where the discrepancy or deviation between the standard pressure and the actual pressure has occurred and easily grasp that a cause of circulation failure exists near the location by confirming the display unit. That is, the location of the circulation circuit where the discrepancy or deviation between the standard pressure and the actual pressure has occurred corresponds to a portion where the pressure measurement unit is provided or a portion of the device provided near the pressure measurement unit. In this manner, the operator or the like can easily grasp the cause of the circulation failure in the extracorporeal circulation. 
     According to the present invention, the above problem is solved by an extracorporeal circulation management program executed by a computer of an extracorporeal circulation management device that manages an extracorporeal circulation device which extracorporeally circulates blood using a circulation circuit, the extracorporeal circulation management program causing the computer to execute a step of displaying an expected flow rate, which is predicted in advance as an expected value of a flow rate of the blood flowing inside the circulation circuit, and an actual flow rate, which is measured by a flow rate measurement unit as an actually measured value of the flow rate of the blood flowing inside the circulation circuit, on a display unit, and displaying a standard pressure calculated based on the expected flow rate by referring to standard information, which represents a relation between the blood flow rate and a pressure loss occurring in a device provided in the circulation circuit and is stored in a storage unit, and an actual pressure related to the device, which is calculated based on an actual pressure measured by a pressure measurement unit as an actually measured value of a pressure of the blood flowing inside the circulation circuit and the actual flow rate, on the display unit. 
     According to the extracorporeal circulation management program of the present invention, the expected flow rate predicted in advance as the expected value of the flow rate of the blood flowing inside the circulation circuit and the actual flow rate measured by the flow rate measurement unit as the actually measured value of the flow rate of the blood flowing inside the circulation circuit are displayed on the display unit. As a result, an operator and the like can easily grasp a discrepancy or deviation between the expected flow rate of the blood in the circulation circuit and the actual flow rate of the blood actually flowing through the circulation circuit by confirming the display unit. In addition, the standard pressure calculated based on the expected flow rate by referring to the standard information stored in the storage unit, which is the standard information representing the relation between the blood flow rate and the pressure loss occurring in the device provided in the circulation circuit, and the actual pressure related to the device, calculated based on the actual pressure measured by the pressure measurement unit as the actually measured value of the pressure of the blood flowing inside the circulation circuit and the actual flow rate measured by the flow rate measurement unit, are displayed on the display unit. As a result, the operator or the like can easily grasp a discrepancy or deviation between the standard pressure calculated based on the expected flow rate and the actual pressure related to the device by observing the display unit. Therefore, when there is a discrepancy or deviation between the expected flow rate and the actual flow rate, the operator or the like can easily grasp the occurrence of the discrepancy or deviation between the expected flow rate and the actual flow rate and grasp a location of the circulation circuit where the discrepancy or deviation between the standard pressure and the actual pressure has occurred and easily grasp that a cause of circulation failure exists near the location by confirming the display unit. That is, the location of the circulation circuit where the discrepancy or deviation between the standard pressure and the actual pressure has occurred corresponds to a portion where the pressure measurement unit is provided or a portion of the device provided near the pressure measurement unit. In this manner, the operator or the like can easily grasp the cause of the circulation failure in the extracorporeal circulation. 
     According to the present invention, it is possible to provide the extracorporeal circulation management device, the extracorporeal circulation device, and the extracorporeal circulation management program that allow the operator or the like to easily grasp the cause of the circulation failure in the extracorporeal circulation. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  is a schematic diagram illustrating an extracorporeal circulation device according to an embodiment of the present invention. 
         FIG. 2  is a schematic diagram illustrating an extracorporeal circulation device according to a modification of the present embodiment. 
         FIG. 3  is a block diagram illustrating a main configuration of an extracorporeal circulation management device according to the present embodiment. 
         FIG. 4  is a block diagram illustrating a main configuration of the extracorporeal circulation device according to the present embodiment. 
         FIG. 5  is a schematic diagram illustrating a standard information storage unit of the present embodiment. 
         FIG. 6  is a graph illustrating an example of standard information related to a blood removing catheter of the present embodiment. 
         FIG. 7  is a graph illustrating an example of standard information related to an oxygenator of the present embodiment. 
         FIG. 8  is a graph illustrating an example of standard information related to a blood feeding catheter of the present embodiment. 
         FIG. 9  is a schematic diagram illustrating a standard pressure calculation unit of the present embodiment. 
         FIG. 10  is a schematic diagram illustrating an actual pressure calculation unit of the present embodiment. 
         FIG. 11  is a schematic diagram illustrating a differential pressure calculation unit of the present embodiment. 
         FIG. 12  is a schematic diagram illustrating a warning information storage unit of the present embodiment. 
         FIG. 13  is a schematic diagram illustrating an example of an image displayed on an external monitor according to the present embodiment. 
         FIG. 14  is a schematic diagram illustrating an example of a relation between arrangements of a circulation circuit and each device of the extracorporeal circulation device according to the present embodiment and a pressure loss. 
         FIG. 15  is a schematic diagram illustrating another example of an image displayed on an external monitor of the present embodiment. 
         FIG. 16  is a flowchart illustrating an example of control executed by a computer of the extracorporeal circulation management device according to the present embodiment. 
         FIG. 17  is a flowchart illustrating an example of the control executed by the computer of the extracorporeal circulation management device according to the present embodiment. 
     
    
    
     DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS 
     Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the drawings. The embodiments to be described below are preferable specific examples of the present invention, and thus, various technically preferable limitations are given. However, a scope of the present invention is not limited to these aspects as long as there is no particular description to limit the present invention in the following description. In addition, the same components will be denoted by the same reference signs in the respective drawings, and the detailed description thereof will be omitted as appropriate. 
       FIG. 1  is a schematic diagram illustrating an extracorporeal circulation device according to an embodiment of the present invention. Incidentally, an electrical connection is indicated by a broken line in  FIG. 1 . The electrical connection may be realized by a wire or wirelessly realized. 
     “Extracorporeal circulation” performed by an extracorporeal circulation device  1  illustrated in  FIG. 1  includes an “extracorporeal circulation operation” and an “auxiliary circulation operation”. The extracorporeal circulation device  1  can perform both the “extracorporeal circulation operation” and the “auxiliary circulation operation”. 
     The “extracorporeal circulation operation” refers to a blood circulation operation and a gas exchange operation (oxygen addition and/or carbon dioxide removal) for blood performed by the extracorporeal circulation device  1 , for example, in a case where blood circulation in the heart is temporarily stopped due to a cardiac surgery. In addition, the “auxiliary circulation operation” refers to a blood circulation operation and a gas exchange operation for blood that are also performed by the extracorporeal circulation device  1  in a case where the heart of a patient P to which the extracorporeal circulation device  1  is applied, hardly exhibits a sufficient function or in a state where it is difficult to sufficiently perform gas exchange by lungs. 
     For example, the extracorporeal circulation device  1  is applied in a case where the heart of the patient P does not operate normally or a case where the heart of the patient P operates normally but the lungs do not operate normally. Meanwhile, the extracorporeal circulation device  1  illustrated in  FIG. 1  is used, for example, in a case of performing a cardiac surgery on the patient P or in subsequent treatment in an ICU. The extracorporeal circulation device  1  illustrated in  FIG. 1  can operate a pump of the extracorporeal circulation device  1  to remove blood from the patient&#39;s vein and exchange a gas in the blood using an oxygenator to oxygenate the blood, and then, perform extracorporeal blood circulation of the oxygenator to return the oxygenated blood back to the patient&#39;s artery or vein. In this manner, the extracorporeal circulation device  1  is a device that acts as a substitute for the heart and lungs. 
     As illustrated in  FIG. 1 , the extracorporeal circulation device  1  has a circulation circuit  1 R that circulates blood. The circulation circuit  1 R includes an oxygenator  2 , a centrifugal pump  3 , a drive motor  4  that drives the centrifugal pump  3 , a venous catheter (blood removing catheter)  5 , an arterial catheter (blood feeding catheter)  6 , and an extracorporeal circulation management device  10 . The venous catheter  5  is an example of a “blood removing catheter” of the present invention. The arterial catheter  6  is an example of a “blood feeding catheter” of the present invention. The centrifugal pump  3  of the present embodiment is an example of an “instrument element” included in a “device” of the present invention. The extracorporeal circulation management device  10  is provided as a controller of the extracorporeal circulation device  1 . Incidentally, the centrifugal pump  3  is also called a blood pump or the like, and may be a pump other than the centrifugal type. 
     The blood removing catheter  5  is also called a venous cannula (blood removing cannula) and is inserted from the femoral vein. A distal end of the blood removing catheter  5  is placed in the right atrium. The blood removing catheter  5  is connected to a blood removal tube (also referred to as a blood removal line)  11  through a connector  8 , is connected to the centrifugal pump  3  through the blood removal tube  11 , and guides blood taken out from the patient P to the centrifugal pump  3  through the blood removal tube  11 . The blood removal tube  11  is a conduit that connects the blood removing catheter  5  and the centrifugal pump  3 , and is the conduit guiding the blood taken out from the patient P through the blood removing catheter  5  to the centrifugal pump  3 . The blood removing catheter  5  of the present embodiment is an example of the “instrument element” included in the “device” of the present invention. 
     The blood feeding catheter  6  is also called an arterial cannula (blood feeding cannula) and is inserted from the femoral artery. The blood feeding catheter  6  is connected to a blood feeding tube (also referred to as a blood feeding line)  12  through the connector  9 , is also connected to the oxygenator  2  through the blood feeding tube  12 , and guides the blood that has passed through the oxygenator  2  to the patient P through the blood feeding tube  12 . The blood feeding tube  12  is a conduit that connects the oxygenator  2  and the blood feeding catheter  6 , and is the conduit guiding the blood having passed through the oxygenator  2  to the patient P. The blood feeding catheter  6  of the present embodiment is an example of the “instrument element” included in the “device” of the present invention. 
     The drive motor  4  controls driving of the centrifugal pump  3  based on a command of the extracorporeal circulation management device  10 . The centrifugal pump  3  is provided on the downstream side of the blood removing catheter  5 , and is driven by receiving a driving force transmitted from the drive motor  4 . The centrifugal pump  3  takes out blood from the patient P through the blood removing catheter  5  and the blood removal tube  11 , sends the blood to the oxygenator  2 , and then, returns the blood to the patient P through the blood feeding tube  12 . 
     The oxygenator  2  is provided on the downstream side of the centrifugal pump  3 . Specifically, the oxygenator  2  is arranged between the centrifugal pump  3  and the blood feeding tube  12 . The oxygenator  2  performs the gas exchange operation (oxygen addition and/or carbon dioxide removal) for blood. The oxygenator  2  is, for example, a membrane oxygenator, but is particularly preferably a hollow fiber membrane oxygenator. An oxygen gas is supplied to the oxygenator  2  through an oxygen supply tube  14 . The oxygenator  2  of the present embodiment is an example of an “instrument element” included in a “device” of the present invention. 
     As the blood removal tube  11  and the blood feeding tube  12 , for example, a conduit made of a synthetic resin which is highly transparent, elastically deformable, and flexible, such as a vinyl chloride resin and silicone rubber, is used. Blood, which is a liquid, flows in a V direction in the blood removal tube  11  and flows in a W direction in the blood feeding tube  12 . 
     The extracorporeal circulation management device  10  acquires various types of information to perform a calculation, generates a control signal to control operations of devices such as the drive motor  4 , a biological monitor  15 , and an external monitor  16 , and transmits the generated control signal to each device. In other words, the extracorporeal circulation management device  10  manages the extracorporeal circulation device  1 . Details of the extracorporeal circulation management device  10  will be described later. In addition, the extracorporeal circulation management device  10  may have a touch panel  52  (see  FIG. 4 ) as an input unit capable of inputting various types of information and as a display unit displaying the various types of information. That is, the “display unit” of the present invention may be the external monitor  16  provided as a separate body from the extracorporeal circulation management device  10 , or may be the touch panel  52  provided in the extracorporeal circulation management device  10 . The touch panel  52  is capable of detecting contact or the like of a finger of an operator or the like. 
     The extracorporeal circulation device  1  according to the present embodiment further includes a pressure measurement unit  20  (see  FIG. 4 ), a flow rate measurement unit  24 , a blood pressure measurement unit  25 , the biological monitor  15 , and the external monitor (display unit)  16 . The external monitor  16  of the present embodiment is an example of the “display unit” of the present invention. In the following description, a case where the “display unit” of the present invention is the external monitor  16  will be described as an example. 
     The pressure measurement unit  20  includes a first pressure sensor  21 , a second pressure sensor  22 , and a third pressure sensor  23 . The first pressure sensor  21  is provided in the circulation circuit  1 R between the blood removing catheter  5  and the centrifugal pump  3 . Specifically, the first pressure sensor  21  is provided on the blood removal tube  11 . The first pressure sensor  21  detects a pressure value of blood flowing in the blood removal tube  11 . The pressure value detected by the first pressure sensor  21  is an example of an “actual pressure measured by a first pressure sensor” of the present invention. The second pressure sensor  22  is provided in the circulation circuit  1 R between the centrifugal pump  3  and the oxygenator  2 . The second pressure sensor  22  detects a pressure value of blood flowing inside the circulation circuit  1 R between the centrifugal pump  3  and the oxygenator  2 . The pressure value detected by the second pressure sensor  22  is an example of an “actual pressure measured by a second pressure sensor” of the present invention. The third pressure sensor  23  is provided in the circulation circuit  1 R between the oxygenator  2  and the blood feeding catheter  6 . Specifically, the third pressure sensor  23  is provided on the blood feeding tube  12 . The third pressure sensor  23  detects a pressure value of blood flowing in the blood feeding tube  12 . The pressure value detected by the third pressure sensor  23  is an example of an “actual pressure measured by a third pressure sensor” of the present invention. 
     The flow rate measurement unit  24  is provided in the circulation circuit  1 R between the blood removing catheter  5  and the oxygenator  2 . Specifically, the flow rate measurement unit  24  is provided on the blood removal tube  11 . Incidentally, the installation position of the flow rate measurement unit  24  is not limited to the blood removal tube  11 , and may be any location in the circulation circuit  1 R. The flow rate measurement unit  24  is, for example, a flow rate sensor, and detects a value of a flow rate of blood flowing inside the circulation circuit  1 R. The value of the flow rate detected by the flow rate measurement unit  24  is an example of an “actual flow rate measured by a flow rate measurement unit” of the present invention. 
     The blood pressure measurement unit  25  is attached to the patient P and detects a pressure value (blood pressure value) of blood flowing through blood vessels of the patient P. The biological monitor  15  displays the blood pressure and other vital signs of patient P detected by the blood pressure measurement unit  25 . The external monitor  16  displays the actual pressure measured by the pressure measurement unit  20  and the actual flow rate measured by the flow rate measurement unit  24  based on the control signal transmitted from the extracorporeal circulation management device  10 . Details of an image displayed on the external monitor  16  will be described later. 
       FIG. 2  is a schematic diagram illustrating an extracorporeal circulation device according to a modification of the present embodiment. When a component of an extracorporeal circulation device  1 A according to the modification illustrated in  FIG. 2  is the same as the component of the extracorporeal circulation device  1  according to the present embodiment described with respect to  FIG. 1 , redundant descriptions will be omitted as appropriate, and differences will be mainly described hereinafter. 
     In the extracorporeal circulation device  1 A according to the modification illustrated in  FIG. 2 , the first pressure sensor  21  is provided in the circulation circuit  1 R between the centrifugal pump  3  and the oxygenator  2 . The first pressure sensor  21  of the present modification detects a pressure value of blood flowing inside the circulation circuit  1 R between the centrifugal pump  3  and the oxygenator  2 . In this case, a pressure value of blood flowing inside the blood removal tube  11  is calculated by subtracting a head of the centrifugal pump  3  from the pressure value detected by the first pressure sensor  21 . 
     The first pressure sensor  21  may be provided in the circulation circuit  1 R between the blood removing catheter  5  and the centrifugal pump  3 , specifically, in the blood removal tube  11 , instead of between the centrifugal pump  3  and the oxygenator  2 . In this case, the pressure value of blood flowing inside the circulation circuit  1 R between the centrifugal pump  3  and the oxygenator  2  is calculated by adding the head of the centrifugal pump  3  to the pressure value detected by the first pressure sensor  21 . In this manner, the first pressure sensor  21  is provided in the circulation circuit  1 R at least between the blood removing catheter  5  and the centrifugal pump  3  or between the centrifugal pump  3  and the oxygenator  2  in the extracorporeal circulation device  1 A according to the present modification. 
     The second pressure sensor  22  of the present modification is provided in the circulation circuit  1 R between the oxygenator  2  and the blood feeding catheter  6 . Specifically, the second pressure sensor  22  is provided on the blood feeding tube  12 . The second pressure sensor  22  detects a pressure value of blood flowing in the blood feeding tube  12 . 
     The pressure measurement unit  20  does not necessarily include the first pressure sensor  21 , the second pressure sensor  22 , and the third pressure sensor  23  as in the extracorporeal circulation device  1 A according to the present modification, and can obtain an operation and an effect of the extracorporeal circulation device according to the present embodiment by providing the first pressure sensor  21  and the second pressure sensor  22 . In the following description, the extracorporeal circulation device  1  described above with respect to  FIG. 1  will be mainly taken as an example for convenience of the description, and the extracorporeal circulation device  1 A illustrated in  FIG. 2  will be taken as an example as necessary. 
       FIG. 3  is a block diagram illustrating a main configuration of an extracorporeal circulation management device according to the present embodiment. The extracorporeal circulation management device according to the present embodiment includes a computer  51  and a storage unit  30 . The computer  51  includes a control unit  40  (see  FIG. 4 ), reads a program  31  stored in the storage unit  30 , and executes various calculations and processes. The storage unit  30  stores the program  31  (extracorporeal circulation management program) to be executed by the computer  51 . The program  31  of the present embodiment is an example of the “extracorporeal circulation management program” of the present invention. Examples of the storage unit  30  include a hard disk drive (HDD) and the like. Incidentally, the program  31  is not limited to being stored in the storage unit  30 , and may be distributed in a state of being stored in advance in a computer-readable storage medium or may be downloaded to the extracorporeal circulation management device  10  via a network. In addition, the storage unit  30  may be an external storage device connected to the computer  51 . 
     Next, a main configuration of the extracorporeal circulation management device  10  according to the present embodiment will be further described with reference to the drawings.  FIG. 4  is a block diagram illustrating the main configuration of the extracorporeal circulation device according to the present embodiment. 
     The extracorporeal circulation management device  10  according to the present embodiment includes the control unit  40 , the storage unit  30 , a touch panel  52 , and a communication unit  53 . The control unit  40  is, for example, a central processing unit (CPU) or the like, reads the program  31  (see  FIG. 3 ) stored in the storage unit  30 , and executes various calculations and processes. The control unit  40  includes a display processing unit  41 , a notification processing unit  42 , a standard pressure calculation unit  43 , an actual pressure calculation unit  44 , a differential flow rate calculation unit  45 , a differential pressure calculation unit  46 , and a standard flow rate calculation unit  47 . The display processing unit  41 , the notification processing unit  42 , the standard pressure calculation unit  43 , the actual pressure calculation unit  44 , the differential flow rate calculation unit  45 , the differential pressure calculation unit  46 , and the standard flow rate calculation unit  47  are realized as the computer  51  executes the program  31  stored in the storage unit  30 . Incidentally, the display processing unit  41 , the notification processing unit  42 , the standard pressure calculation unit  43 , the actual pressure calculation unit  44 , the differential flow rate calculation unit  45 , the differential pressure calculation unit  46 , and the standard flow rate calculation unit  47  may be realized by hardware, or may be realized by a combination of hardware and software. The storage unit  30  stores the program  31  described above with respect to  FIG. 3 , and includes an expected flow rate storage unit  32 , a standard information storage unit  33 , a pump characteristic storage unit  34 , and a warning information storage unit  35 . 
     The display processing unit  41  executes a process of displaying an expected flow rate predicted in advance as an expected value of a flow rate of blood flowing inside the circulation circuit  1 R and an actual flow rate, measured by the flow rate measurement unit  24  as an actually measured value of the flow rate of the blood flowing inside the circulation circuit, on the external monitor  16 . In the present embodiment, the “expected flow rate” is a nominal or target flow rate value of blood calculated and determined by the standard flow rate calculation unit  47  using, for example, patient information (for example, height, weight, and the like) input by the touch panel  52  in response to the operator&#39;s operation on the touch panel  52  and standard information  334  (see  FIG. 5 ) related to the circulation circuit  1 R stored in the standard information storage unit  33 . The expected flow rate calculated by the standard flow rate calculation unit  47  is transmitted from the standard flow rate calculation unit  47  to the expected flow rate storage unit  32  of the storage unit  30  and stored therein. Alternatively, the “expected flow rate” is a nominal flow rate value determined and predicted in advance by the operator or the like, and is an expected value of the flow rate of blood flowing inside the circulation circuit  1 R. The expected flow rate determined by the operator or the like is input by, for example, the touch panel  52  and is stored in the expected flow rate storage unit  32  of the storage unit  30 . 
     In addition, the display processing unit  41  executes a process of displaying both a standard pressure calculated based on the expected flow rate by referring to the standard information stored in the standard information storage unit  33  of the storage unit  30  and an actual pressure related to a device, calculated based on the actual pressure measured by the pressure measurement unit  20  as an actually measured value of the pressure of blood flowing inside the circulation circuit  1 R and the actual flow rate measured by the flow rate measurement unit  24 , on the external monitor  16 . Details of the standard information and the standard pressure will be described later. 
     The notification processing unit  42  executes a process of providing notification of a warning when a predetermined condition is satisfied. For example, the warning notification is executed by displaying warning information (warning content) of the storage unit  30  on the external monitor  16 . Alternatively, the warning notification may be executed, for example, by generation of light or sound. 
     The standard pressure calculation unit  43  refers to the standard information stored in the standard information storage unit  33  and calculates a standard pressure based on the expected flow rate stored in the expected flow rate storage unit  32 . The standard information is information that represents a relation between the blood flow rate and a pressure loss occurring in each device such as the blood removing catheter  5 , the oxygenator  2 , and the blood feeding catheter  6  provided in the circulation circuit  1 R. The standard pressure refers to the expected pressure loss occurring in each device provided in the circulation circuit  1 R when the blood flow rate is the expected flow rate. 
     Here, the standard information storage unit  33  and the standard information stored in the standard information storage unit  33  will be further described with reference to  FIGS. 5 to 8 . In addition, the standard pressure calculation unit  43  will be further described with reference to  FIG. 9 . 
       FIG. 5  is a schematic diagram illustrating the standard information storage unit of the present embodiment.  FIG. 6  is a graph illustrating an example of standard information related to the blood removing catheter of the present embodiment.  FIG. 7  is a graph illustrating an example of standard information related to the oxygenator of the present embodiment.  FIG. 8  is a graph illustrating an example of standard information related to the blood feeding catheter of the present embodiment.  FIG. 9  is a schematic diagram illustrating the standard pressure calculation unit of the present embodiment. 
     As illustrated in  FIG. 5 , the standard information stored in the standard information storage unit  33  includes standard information  331  related to the blood removing catheter  5 , standard information  332  related to the oxygenator  2 , standard information  333  related to the blood feeding catheter  6 , and the standard information  334  related to the circulation circuit  1 R. 
     An example of the standard information  331  related to the blood removing catheter  5  is given as illustrated in the graph illustrated in  FIG. 6 . That is, the horizontal axis of the graph illustrated in  FIG. 6  is a flow rate (L/min) of blood flowing through the blood removing catheter  5 . The vertical axis of the graph illustrated in  FIG. 6  is a pressure loss (mmHg) that occurs in the blood removing catheter  5 . As a condition of the graph illustrated in  FIG. 6 , the blood is bovine blood. Each of “18 Fr.”, “19.5 Fr.”, and “21 Fr.” described in the graph of  FIG. 6  represents a French size of the blood removing catheter  5 . For example, when the flow rate of blood flowing through the blood removing catheter  5  is 2.5 L/min in the case where the French size of the blood removing catheter  5  is “21 Fr.”, the pressure loss that occurs in the blood removing catheter  5  is about 63 mmHg. 
     An example of the standard information  332  related to oxygenator  2  is given as illustrated in the graph illustrated in  FIG. 7 . That is, the horizontal axis of the graph illustrated in  FIG. 7  is a flow rate (L/min) of blood flowing through the oxygenator  2 . The vertical axis of the graph illustrated in  FIG. 7  is a pressure loss (mmHg) that occurs in the oxygenator  2 . As a condition of the graph illustrated in  FIG. 7 , the blood is bovine blood. For example, when the flow rate of blood flowing through the oxygenator  2  is 2. 5 L/min, the pressure loss generated in the oxygenator  2  is about 28 mmHg. 
     An example of the standard information  333  related to the blood feeding catheter  6  is given as illustrated in the graph illustrated in  FIG. 8 . That is, the horizontal axis of the graph illustrated in  FIG. 8  is a flow rate (L/min) of blood flowing through the blood feeding catheter  6 . The vertical axis of the graph illustrated in  FIG. 8  is a pressure loss (mmHg) that occurs in the blood feeding catheter  6 . As a condition of the graph illustrated in  FIG. 8 , the blood is bovine blood. Each of “13.5 Fr.”, “15 Fr.” and “16.5 Fr.” described in the graph of  FIG. 8  represents a French size of the blood feeding catheter  6 . For example, when the flow rate of blood flowing through the blood feeding catheter  6  is 2.5 L/min in the case where the French size of the blood feeding catheter  6  is “16.5 Fr.”, the pressure loss that occurs in the blood feeding catheter  6  is about 87 mmHg. 
     The standard information  334  related to the circulation circuit  1 R includes the standard information  331  related to the blood removing catheter  5 , the standard information  332  related to the oxygenator  2 , the standard information  333  related to the blood feeding catheter  6 , and standard information related to tubes used in the circulation circuit  1 R. Examples of the standard information related to the tubes used in the circulation circuit  1 R can include standard information related to the blood removal tube  11 , standard information related to the blood feeding tube  12 , and the like. 
     As illustrated in  FIG. 9 , the standard pressure calculation unit  43  of the present embodiment includes a standard pressure calculation unit  431  related to the blood removing catheter  5 , a standard pressure calculation unit  432  related to the oxygenator  2 , and a standard pressure calculation unit  433  related to the blood feeding catheter  6 . The standard pressure calculation unit  431  related to the blood removing catheter  5  refers to the standard information  331  related to the blood removing catheter  5  and calculates a standard pressure related to the blood removing catheter  5  based on the expected flow rate stored in the expected flow rate storage unit  32 . The standard pressure related to the blood removing catheter  5  refers to a pressure loss that occurs in the blood removing catheter  5  when the blood flow rate is the expected flow rate. For example, when the expected flow rate stored in the expected flow rate storage unit  32  is 2.5 L/min, the standard pressure calculation unit  431  related to the blood removing catheter  5  calculates about 63 mmHg as the standard pressure (i.e., pressure loss or drop) related to the blood removing catheter  5 . 
     The standard pressure calculation unit  432  related to the oxygenator  2  refers to the standard information  332  related to the oxygenator  2  and calculates a standard pressure related to the oxygenator  2  based on the expected flow rate stored in the expected flow rate storage unit  32 . The standard pressure related to the oxygenator  2  refers to a pressure loss that occurs in the oxygenator  2  when the blood flow rate is the expected flow rate. For example, when the expected flow rate stored in the expected flow rate storage unit  32  is 2.5 L/min, the standard pressure calculation unit  432  related to the oxygenator  2  calculates about 28 mmHg as the standard pressure (loss) related to the oxygenator  2 . 
     The standard pressure calculation unit  433  related to the blood feeding catheter  6  refers to the standard information  333  related to the blood feeding catheter  6 , and calculates a standard pressure related to the blood feeding catheter  6  based on the expected flow rate stored in the expected flow rate storage unit  32 . The standard pressure related to the blood feeding catheter  6  refers to a pressure loss that occurs in the blood feeding catheter  6  when the blood flow rate is the expected flow rate. For example, when the expected flow rate stored in the expected flow rate storage unit  32  is 2.5 L/min, the standard pressure calculation unit  433  related to the blood feeding catheter  6  calculates about 87 mmHg as the standard pressure (loss) related to the blood feeding catheter  6 . 
     Subsequently, the main configuration of the extracorporeal circulation management device  10  will be further described returning to  FIG. 4 . The actual pressure calculation unit  44  calculates a pressure loss that actually occurs in each device, such as the blood removing catheter  5 , the oxygenator  2 , and the blood feeding catheter  6  provided in the circulation circuit  1 R, based on the actual pressure measured by the pressure measurement unit  20  and the actual flow rate measured by the flow rate measurement unit  24 . 
     Here, the actual pressure calculation unit  44  will be further described with reference to  FIG. 10 .  FIG. 10  is a schematic diagram illustrating the actual pressure calculation unit of the present embodiment. As illustrated in  FIG. 10 , the actual pressure calculation unit  44  of the present embodiment includes an actual pressure calculation unit  441  related to the blood removing catheter  5 , an actual pressure calculation unit  442  related to the oxygenator  2 , and an actual pressure calculation unit  443  related to the blood feeding catheter  6 . 
     The actual pressure calculation unit  441  related to the blood removing catheter  5  calculates an actual pressure related to the blood removing catheter  5  based on the actual pressure measured by the first pressure sensor  21  and the actual flow rate measured by the flow rate measurement unit  24 . Specifically, the actual pressure calculation unit  441  related to the blood removing catheter  5  calculates a value, obtained by subtracting a blood pressure (for example, central venous pressure (CVP)) displayed on the biological monitor  15  from an actually measured value measured by the first pressure sensor  21 , as a pressure loss that actually occurs in the blood removing catheter  5 . 
     Incidentally, in the extracorporeal circulation device  1 A according to the modification described above with respect to  FIG. 2 , the actual pressure calculation unit  441  related to the blood removing catheter  5  calculates the actual pressure related to the blood removing catheter  5  based on the actual pressure measured by the first pressure sensor  21 , the head of the centrifugal pump  3 , and the actual flow rate measured by the flow rate measurement unit  24 . Specifically, the actual pressure calculation unit  441  related to the blood removing catheter  5  calculates a value, obtained by subtracting the head of the centrifugal pump  3  from the actually measured value measured by the first pressure sensor  21 , as a pressure value of blood flowing inside the blood removal tube  11  (blood pressure inside the blood removal tube  11 ). Further, the actual pressure calculation unit  441  related to the blood removing catheter  5  calculates a value, obtained by subtracting a blood pressure displayed on the biological monitor  15  (blood pressure of the patient P detected by the blood pressure measurement unit  25 : for example, central venous pressure (CVP)) from the blood pressure in the blood removal tube  11 , as a pressure loss that actually occurs in the blood removing catheter  5 . 
     The actual pressure calculation unit  442  related to the oxygenator  2  calculates an actual pressure related to the oxygenator  2  based on the actual pressure measured by the second pressure sensor  22 , the actual pressure measured by the third pressure sensor  23 , and the actual flow rate measured by the flow rate measurement unit  24 . Specifically, the actual pressure calculation unit  442  related to the oxygenator  2  calculates a value, obtained by subtracting an actually measured value measured by the second pressure sensor  22  from an actually measured value measured by the third pressure sensor  23 , as a pressure loss that actually occurs in the oxygenator  2 . 
     Incidentally, in the extracorporeal circulation device  1 A according to the modification described above with respect to  FIG. 2 , the actual pressure calculation unit  442  related to the oxygenator  2  calculates the actual pressure related to the oxygenator  2  based on the actual pressure measured by the first pressure sensor  21 , the actual pressure measured by the second pressure sensor  22 , and the actual flow rate measured by the flow rate measurement unit  24 . Specifically, the actual pressure calculation unit  442  related to the oxygenator  2  calculates a value, obtained by subtracting the actually measured value measured by the first pressure sensor  21  from the actually measured value measured by the second pressure sensor  22 , as a pressure loss that actually occurs in the oxygenator  2 . Alternatively, in the extracorporeal circulation device  1 A according to the modification described with respect to  FIG. 2 , the actual pressure calculation unit  442  related to the oxygenator  2  calculates a value, obtained by adding the head of the centrifugal pump  3  to the actually measured value measured by the first pressure sensor  21 , as a pressure value flowing in a tube between the centrifugal pump  3  and the oxygenator  2  (a blood pressure in the tube between the centrifugal pump  3  and the oxygenator  2 ) when the first pressure sensor  21  is provided in the circulation circuit  1 R between the blood removing catheter  5  and the centrifugal pump  3 . Further, the actual pressure calculation unit  442  related to the oxygenator  2  calculates a value, obtained by subtracting the blood pressure in the tube between the centrifugal pump  3  and the oxygenator  2  from the actually measured value measured by the second pressure sensor  22 , as the pressure loss that actually occurs in the oxygenator  2 . 
     The actual pressure calculation unit  443  related to the blood feeding catheter  6  calculates an actual pressure related to the blood feeding catheter  6  based on the actual pressure measured by the third pressure sensor  23  and the actual flow rate measured by the flow rate measurement unit  24 . Specifically, the actual pressure calculation unit  443  related to the blood feeding catheter  6  calculates a value, obtained by subtracting the actually measured value measured by the third pressure sensor  23  from a blood pressure (for example, average blood pressure) displayed on the biological monitor  15 , as a pressure loss that actually occurs in the blood feeding catheter  6 . 
     Incidentally, in the extracorporeal circulation device  1 A according to the modification described with respect to  FIG. 2 , the actual pressure calculation unit  443  related to the blood feeding catheter  6  calculates the actual pressure related to the blood feeding catheter  6  based on the actual pressure measured by the second pressure sensor  22  and the actual flow rate measured by the flow rate measurement unit  24 . Specifically, the actual pressure calculation unit  443  related to the blood feeding catheter  6  calculates a value, obtained by subtracting the actually measured value measured by the second pressure sensor  22  from the blood pressure (for example, average blood pressure) displayed on the biological monitor  15 , as the pressure loss that actually occurs in the blood feeding catheter  6 . 
     Subsequently, the main configuration of the extracorporeal circulation management device  10  will be further described returning to  FIG. 4 . The differential flow rate calculation unit  45  calculates a differential flow rate representing a difference between an expected flow rate and an actual flow rate. Specifically, the differential flow rate calculation unit  45  calculates a difference between the expected flow rate stored in the expected flow rate storage unit  32  and the actually measured value (actual flow rate) measured by the flow rate measurement unit  24  as the differential flow rate. 
     The differential pressure calculation unit  46  calculates a differential pressure representing a difference between a standard pressure and an actual pressure. Specifically, the differential pressure calculation unit  46  calculates a difference between the standard pressure calculated by the standard pressure calculation unit  43  and the actual pressure related to each device calculated by the actual pressure calculation unit  44  as the differential pressure. 
     Here, the differential pressure calculation unit  46  will be further described with reference to  FIG. 11 .  FIG. 11  is a schematic diagram illustrating the differential pressure calculation unit of the present embodiment. As illustrated in  FIG. 11 , the differential pressure calculation unit  46  of the present embodiment includes a differential pressure calculation unit  461  related to the blood removing catheter  5 , a differential pressure calculation unit  462  related to the oxygenator  2 , and a differential pressure calculation unit  463  related to the blood feeding catheter  6 . 
     The differential pressure calculation unit  461  related to the blood removing catheter  5  calculates a differential pressure related to the blood removing catheter  5  which represents a difference between the standard pressure related to the blood removing catheter  5  and the actual pressure related to the blood removing catheter  5 . Specifically, the differential pressure calculation unit  461  related to the blood removing catheter  5  calculates a difference between the standard pressure related to the blood removing catheter  5  calculated by the standard pressure calculation unit  431  related to the blood removing catheter  5  and the actual pressure related to the blood removing catheter  5  calculated by the actual pressure calculation unit  441  related to the blood removing catheter  5  as the differential pressure related to the blood removing catheter  5 . 
     The differential pressure calculation unit  462  related to the oxygenator  2  calculates a differential pressure related to the oxygenator  2  which represents a difference between the standard pressure related to the oxygenator  2  and the actual pressure related to the oxygenator  2 . Specifically, the differential pressure calculation unit  462  related to the oxygenator  2  calculates a difference between the standard pressure related to the oxygenator  2  calculated by the standard pressure calculation unit  432  related to the oxygenator  2  and the actual pressure related to the oxygenator  2  calculated by the actual pressure calculation unit  442  related to the oxygenator  2  as the differential pressure related to the oxygenator  2 . 
     The differential pressure calculation unit  463  related to the blood feeding catheter  6  calculates a differential pressure related to the blood feeding catheter  6  which represents a difference between the standard pressure related to the blood feeding catheter  6  and the actual pressure related to the blood feeding catheter  6 . Specifically, the differential pressure calculation unit  463  related to the blood feeding catheter  6  calculates a difference between the standard pressure related to the blood feeding catheter  6  calculated by the standard pressure calculation unit  433  related to the blood feeding catheter  6  and the actual pressure related to the blood feeding catheter  6  calculated by the actual pressure calculation unit  443  related to the blood feeding catheter  6  as the differential pressure related to the blood feeding catheter  6 . 
     Subsequently, the main configuration of the extracorporeal circulation management device  10  will be further described returning to  FIG. 4 . The expected flow rate storage unit  32  stores the expected flow rate calculated by the standard flow rate calculation unit  47  and transmitted from the standard flow rate calculation unit  47 . Alternatively, the expected flow rate storage unit  32  stores the expected flow rate determined by the operator or the like and input by, for example, the touch panel  52 . The standard information storage unit  33  is given as described above with respect to  FIGS. 5 to 8 . 
     The pump characteristic storage unit stores information on a characteristic of the centrifugal pump  3 . Examples of the information on the characteristic of the centrifugal pump  3  include a graph illustrating a relation between a flow rate (L/min) of blood sent by the centrifugal pump  3  and a head (mmHg) of the centrifugal pump  3 . For example, in the graph illustrating the characteristic of the centrifugal pump  3 , the relation between the flow rate (L/min) of blood sent by the centrifugal pump  3  and the head (mmHg) of the centrifugal pump  3  is set depending on a rotational speed (rpm) of the centrifugal pump  3 . 
     The warning information storage unit  35  stores warning information (warning content) notification of which is provided by the notification processing unit  42 . Here, the differential pressure calculation unit  46  will be further described with reference to  FIG. 12 .  FIG. 12  is a schematic diagram illustrating the warning information storage unit of the present embodiment. 
     As illustrated in  FIG. 12 , the warning information storage unit  35  stores warning information data that can be expected by combining a flow rate and a pressure. For example, in a case where the actual flow rate measured by the flow rate measurement unit  24  decreases and the differential pressure related to the blood removing catheter  5  increases, the notification processing unit  42  refers to the warning information stored in the warning information storage unit  35  and displays that there is a suspicion of blood removal failure on the external monitor  16 . For example, the notification processing unit  42  displays that there is a “possibility of clogging of the blood removing catheter  5 ” due to the distal end of the blood removing catheter  5  coming into contact with a blood vessel wall or there is a “possibility of a kink of the blood removal tube  11 ” on the external monitor  16  as the suspicion of the blood removal failure. Incidentally, the case where the differential pressure related to the blood removing catheter  5  increases corresponds to, for example, a case where a blood removal pressure (negative pressure) increases. 
     In addition, for example, in a case where the actual flow rate measured by the flow rate measurement unit  24  decreases and the differential pressure related to the oxygenator  2  increases, the notification processing unit  42  refers to the warning information stored in the warning information storage unit  35  and displays that there is a suspicion of oxygenator failure on the external monitor  16 . For example, the notification processing unit  42  displays that there is a “possibility of clogging of the oxygenator  2 ” due to the life of the oxygenator  2  or the like on the external monitor  16  as the suspicion of oxygenator failure. 
     In addition, for example, in a case where the actual flow rate measured by the flow rate measurement unit  24  decreases and the differential pressure related to the blood feeding catheter  6  increases, the notification processing unit  42  refers to the warning information stored in the warning information storage unit  35  and displays that there is a suspicion of blood feeding failure on the external monitor  16 . For example, the notification processing unit  42  displays that there is a “possibility of clogging of the blood feeding catheter  6 ” due to a distal end of the blood feeding catheter  6  coming into contact with a blood vessel wall or there is a “possibility of a kink of the blood feeding tube  12 ” on the external monitor  16  as the suspicion of the blood feeding failure. Incidentally, the case where the differential pressure of the blood feeding catheter  6  increases corresponds to, for example, a case where a blood feeding pressure (positive pressure) increases. 
     Subsequently, the main configuration of the extracorporeal circulation management device  10  will be further described returning to  FIG. 4 . The communication unit  53  communicates with the drive motor  4 , the biological monitor  15 , the external monitor  16 , the pressure measurement unit  20 , and the flow rate measurement unit  24 , and transmits and receives various types of information and various signals. 
     Next, an example of an image displayed on the external monitor  16  of the present embodiment will be described with reference to the drawings.  FIG. 13  is a schematic diagram illustrating an example of the image displayed on the external monitor according to the present embodiment.  FIG. 14  is a schematic diagram illustrating an example of a relation between arrangements of the circulation circuit and each device of the extracorporeal circulation device according to the present embodiment and a pressure loss. 
     As illustrated in  FIG. 13 , the display processing unit  41  of the extracorporeal circulation management device  10  according to the present embodiment displays an expected flow rate  66  (labelled in  FIG. 13  as “Assumed Flow Rate”) stored in the expected flow rate storage unit  32  and an actual flow rate  67  measured by the flow rate measurement unit  24  on the external monitor  16 , using side-by-side bar graphs. In addition, the display processing unit  41  displays standard pressures  71 ,  74 , and  77  calculated by the standard pressure calculation unit  43  and actual pressures  72 ,  75 , and  78  related to the respective devices calculated by the actual pressure calculation unit  44  on the external monitor  16 . 
     Further, the display processing unit  41  displays a differential flow rate  68 , which represents a difference between the expected flow rate  66  and the actual flow rate  67 , and differential pressures  73 ,  76 , and  79  each of which represents a difference between each of the standard pressures  71 ,  74 , and  77  and each of the actual pressures  72 ,  75 , and  78  related to the respective devices on the external monitor  16 . 
     To be specific, the display processing unit  41  displays the standard pressure  71  related to the blood removing catheter  5 , calculated based on the expected flow rate  66  by the standard pressure calculation unit  431  related to the blood removing catheter  5 , and the actual pressure  72  related to the blood removing catheter  5 , calculated by the actual pressure calculation unit  441  related to the blood removing catheter  5  based on the actual pressure measured by the first pressure sensor  21  and the actual flow rate  67  measured by the flow rate measurement unit  24 , on the external monitor  16 . In the example of the image illustrated in  FIG. 13 , the display processing unit  41  displays the standard pressure  71  related to the blood removing catheter  5  and the actual pressure  72  related to the blood removing catheter  5  in parallel. Further, the display processing unit  41  displays the differential pressure  73  related to the blood removing catheter  5  calculated by the differential pressure calculation unit  461  related to the blood removing catheter  5 , which represents the difference between the standard pressure  71  related to the blood removing catheter  5  and the actual pressure  72  related to the blood removing catheter  5 , on the external monitor  16 . In the example of the image illustrated in  FIG. 13 , the display processing unit  41  displays the standard pressure  71  related to the blood removing catheter  5 , the actual pressure  72  related to the blood removing catheter  5 , and the differential pressure  73  related to the blood removing catheter  5  in parallel. 
     In addition, the display processing unit  41  displays the standard pressure  74  related to the oxygenator  2 , calculated based on the expected flow rate  66  by the standard pressure calculation unit  432  related to the oxygenator  2 , and the actual pressure  75  related to the oxygenator  2 , calculated by the actual pressure calculation unit  442  related to the oxygenator  2  based on the actual pressures measured by the second pressure sensor  22  and the third pressure sensor  23  and the actual flow rate  67  measured by the flow rate measurement unit  24 , on the external monitor  16 . In the example of the image illustrated in  FIG. 13 , the display processing unit  41  displays the standard pressure  74  related to the oxygenator  2  and the actual pressure  75  related to the oxygenator  2  in parallel. Further, the display processing unit  41  displays the differential pressure  76  related to the oxygenator  2  calculated by the differential pressure calculation unit  462  related to the oxygenator  2 , which represents the difference between the standard pressure  74  related to the oxygenator  2  and the actual pressure  75  related to the oxygenator  2 , on the external monitor  16 . In the example of the image illustrated in  FIG. 13 , the display processing unit  41  displays the standard pressure  74  related to the oxygenator  2 , the actual pressure  75  related to the oxygenator  2 , and the differential pressure  76  related to the oxygenator  2  in parallel. 
     In addition, the display processing unit  41  displays the standard pressure  77  related to the blood feeding catheter  6 , calculated based on the expected flow rate  66  by the standard pressure calculation unit  433  related to the blood feeding catheter  6 , and the actual pressure  78  related to the blood feeding catheter  6 , calculated by the actual pressure calculation unit  443  related to the blood feeding catheter  6  based on the actual pressure measured by the third pressure sensor  23  and the actual flow rate  67  measured by the flow rate measurement unit  24 , on the external monitor  16 . In the example of the image illustrated in  FIG. 13 , the display processing unit  41  displays the standard pressure  77  related to the blood feeding catheter  6  and the actual pressure  78  related to the blood feeding catheter  6  in parallel. Further, the display processing unit  41  displays the differential pressure  79  related to the blood feeding catheter  6  calculated by the differential pressure calculation unit  463  related to the blood feeding catheter  6 , which represents the difference between the standard pressure  77  related to the blood feeding catheter  6  and the actual pressure  78  related to the blood feeding catheter  6 , on the external monitor  16 . In the example of the image illustrated in  FIG. 13 , the display processing unit  41  displays the standard pressure  77  related to the blood feeding catheter  6 , the actual pressure  78  related to the blood feeding catheter  6 , and the differential pressure  79  related to the blood feeding catheter  6  in parallel. 
     According to the extracorporeal circulation device  1  and the extracorporeal circulation management device  10  of the present embodiment, the operator or the like can easily grasp a discrepancy or deviation between the expected flow rate  66  of blood in the circulation circuit  1 R and the actual flow rate  67  of the blood actually flowing in the circulation circuit  1 R by confirming the external monitor  16 . In addition, the operator or the like can easily grasp a discrepancy or deviation between each of the standard pressures  71 ,  74 , and  77  calculated based on the expected flow rate  66  and each of the actual pressures  72 ,  75 , and  78  related to the respective devices (the blood removing catheter  5 , the oxygenator  2 , and the blood feeding catheter  6 ) by observing the external monitor  16 . Therefore, when there is the discrepancy or deviation between the expected flow rate  66  and the actual flow rate  67 , the operator or the like can easily grasp the occurrence of the discrepancy or deviation between the expected flow rate  66  and the actual flow rate  67  and grasp a location of the circulation circuit  1 R where the discrepancy or deviation between the standard pressure  71 ,  74 , or  77  and the actual pressure  72 ,  75 , or  78  has occurred and easily grasp that a cause of circulation failure exists near the location by confirming the external monitor  16 . That is, the location of the circulation circuit  1 R where the discrepancy or deviation between the standard pressure  71 ,  74 , or  77  and the actual pressure  72 ,  75 , or  78  has occurred corresponds to a portion where the pressure measurement unit  20  is provided or a portion of each device provided near the pressure measurement unit  20 . In this manner, the operator or the like can easily grasp the cause of the circulation failure in the extracorporeal circulation. 
     In addition, the differential flow rate  68  and the differential pressures  73 ,  76 , and  79  are further displayed on the external monitor  16  as described above. As a result, the operator or the like can more easily grasp the discrepancy or deviation between the expected flow rate  66  and the actual flow rate  67  and the discrepancy or deviation between the standard pressure  71 ,  74 , or  77  and the actual pressure  72 ,  75 , or  78  by confirming the external monitor  16 . As described above, the standard pressure  71 ,  74 , or  77  is calculated based on the standard information  331 ,  332 , or  333  stored in the standard information storage unit  33  and the expected flow rate  66  stored in the expected flow rate storage unit  32 . That is, the standard pressures  71 ,  74 , and  77  change depending on the expected flow rate  66 . Therefore, a discrepancy or deviation sometimes occurs between the standard pressure  71 ,  74 , or  77  and the actual pressure  72 ,  75 , or  78  even if the actual pressure  72 ,  75 , or  78  does not change at first glance. On the other hand, according to the extracorporeal circulation device  1  and the extracorporeal circulation management device  10  of the present embodiment, the operator or the like can more easily grasp the discrepancy or deviation between the standard pressure  71 ,  74 , or  77  and the actual pressure  72 ,  75 , or  78  by confirming the external monitor  16 . 
     In addition, as illustrated in  FIG. 13 , the standard pressure  71 , the actual pressure  72 , and the differential pressure  73  related to the blood removing catheter  5 , the standard pressure  74 , the actual pressure  75 , and the differential pressure  76  related to the oxygenator  2 , and the standard pressure  77 , the actual pressure  78 , and the differential pressure  79  related to the blood feeding catheter  6  are displayed in parallel according to the actual arrangement of each device or per actual arrangement of each device. As a result, the operator or the like can more easily grasp the discrepancy or deviation between the standard pressure  71 ,  74 , or  77  and the actual pressure  72 ,  75 , or  78 , and more concretely and easily grasp a location of the circulation circuit  1 R where the discrepancy or deviation between the standard pressure  71 ,  74 , or  77  and the actual pressure  72 ,  75 , or  78  has occurred and easily grasp that a cause of circulation failure exists near the location by observing the external monitor  16  as one display unit. 
     In addition, as illustrated in  FIG. 13 , all the expected flow rate  66 , the actual flow rate  67 , the differential flow rate  68 , the standard pressure  71  related to the blood removing catheter  5 , the standard pressure  74  related to the oxygenator  2 , the standard pressure  77  related to the blood feeding catheter  6 , the actual pressure  72  related to the blood removing catheter  5 , the actual pressure  75  related to the oxygenator  2 , the actual pressure  78  related to the blood feeding catheter  6 , the differential pressure  73  related to the blood removing catheter  5 , the differential pressure  76  related to the oxygenator  2 , and the differential pressure  79  related to the blood feeding catheter  6  are displayed simultaneously and in parallel on the external monitor  16  as one display unit. As a result, the operator or the like can more easily grasp the discrepancy or deviation between the standard pressure  71 ,  74 , or  77  and the actual pressure  72 ,  75 , or  78 , and more concretely and easily grasp a location of the circulation circuit  1 R where the discrepancy or deviation between the standard pressure  71 ,  74 , or  77  and the actual pressure  72 ,  75 , or  78  has occurred and easily grasp that a cause of circulation failure exists near the location by confirming the external monitor  16  as one display unit. That is, a location of the circulation circuit  1 R where a discrepancy or deviation between the standard pressure  71 ,  74 , or  77  and the actual pressure  72 ,  75 , or  78  has occurred corresponds to a portion where a pressure sensor detecting an abnormal value among the first pressure sensor  21 , the second pressure sensor  22 , and the third pressure sensor  23  is provided or a portion of an instrument element provided near the pressure sensor detecting the abnormal value among the blood removing catheter  5 , the oxygenator  2 , and the blood feeding catheter  6 . In addition, the image (bar graph) displayed on the external monitor  16  changes in real time. As a result, the operator or the like can immediately grasp the discrepancy or deviation between the standard pressure  71 ,  74 , or  77  and the actual pressure  72 ,  75 , or  78 . 
     In addition, as illustrated in  FIG. 13 , the display processing unit  41  displays a French size  61  of the blood removing catheter  5 , a type  62  of the oxygenator  2 , and a French size  63  of the blood feeding catheter  6  on the external monitor  16 . The operator or the like can easily change settings of at least any of the French size  61  of the blood removing catheter  5 , the type  62  of the oxygenator  2 , and the French size  63  of the blood feeding catheter  6  on the image displayed on the external monitor  16 . As a result, the operator or the like can change settings of the standard pressure  71  related to the blood removing catheter  5 , the standard pressure  74  related to the oxygenator  2 , and the standard pressure  77  related to the blood feeding catheter  6  by changing settings of at least any of the French size  61  of the blood removing catheter  5 , the type  62  of the oxygenator  2 , and the French size  63  of the blood feeding catheter  6  on the image displayed on the external monitor  16 . A relation between the French size  61  of the blood removing catheter  5  and the standard pressure  71  related to the blood removing catheter  5  and a relation between the French size  63  of the blood feeding catheter  6  and the standard pressure  77  related to the blood feeding catheter  6  are the same as those described above with respect to  FIGS. 6 and 8 . 
     Further, the display processing unit  41  displays an overall pressure distribution  81  of the extracorporeal circulation device  1  on the external monitor  16 . The overall pressure distribution  81  of the extracorporeal circulation device  1  includes a head  82  of the centrifugal pump  3 , the actual pressure  72  related to the blood removing catheter  5 , the actual pressure  75  related to the oxygenator  2 , the actual pressure  78  related to the blood feeding catheter  6 , and a circuit fixed pressure  84 . The circuit fixed pressure  84  is a pressure applied to a tube connecting the blood removing catheter  5 , the centrifugal pump  3 , the oxygenator  2 , and the blood feeding catheter  6 , and is, for example, a pressure applied to the blood removal tube  11 , a pressure applied to the blood feeding tube  12 , or the like. 
       FIG. 15  is a schematic diagram illustrating another example of the image displayed on the external monitor of the present embodiment. On the image displayed on the external monitor  16  described above with respect to  FIG. 13 , the standard pressure  71  related to the blood removing catheter  5 , the standard pressure  74  related to the oxygenator  2 , the standard pressure  77  related to the blood feeding catheter  6 , the actual pressure  72  related to the blood removing catheter  5 , the actual pressure  75  related to the oxygenator  2 , the actual pressure  78  related to the blood feeding catheter  6 , the differential pressure  73  related to the blood removing catheter  5 , the differential pressure  76  related to the oxygenator  2 , the differential pressure  79  related to the blood feeding catheter  6 , and the head  82  of the centrifugal pump  3  are illustrated using bar graphs. In contrast, on the image illustrated in  FIG. 15 , blood pressure information displayed on the biological monitor  15 , such as the standard pressure  71  related to the blood removing catheter  5 , the standard pressure  74  related to the oxygenator  2 , the standard pressure  77  related to the blood feeding catheter  6 , the actual pressure  72  related to the blood removing catheter  5 , the actual pressure  75  related to the oxygenator  2 , the actual pressure  78  related to the blood feeding catheter  6 , the differential pressure  73  related to the blood removing catheter  5 , the differential pressure  76  related to the oxygenator  2 , and the differential pressure  79  related to the blood feeding catheter  6 , the standard head  82  of the centrifugal pump  3 , an actual head  83  of the centrifugal pump  3 , and a central venous pressure (CVP)  85 , is illustrated using a line graph. In this regard, the image illustrated in  FIG. 15  is different from the image illustrated in  FIG. 13 . 
     On the image illustrated in  FIG. 15 , the operator or the like can more easily grasp a discrepancy or deviation between the standard pressure  71 ,  74 , or  77  and the actual pressure  72 ,  75 , or  78  while confirming the relation between the arrangements of the circulation circuit  1 R and the respective devices of the extracorporeal circulation device  1  and the pressure loss using the external monitor  16 . In other words, the operator or the like can more concretely and easily grasp a location of the circulation circuit  1 R where the discrepancy or deviation between the standard pressure  71 ,  74 , or  77  and the actual pressure  72 ,  75 , or  78  has occurred, and easily grasp that a cause of circulation failure exists near the location. In addition, the image (line graph) displayed on the external monitor  16  changes in real time. As a result, the operator or the like can immediately grasp the discrepancy or deviation between the standard pressure  71 ,  74 , or  77  and the actual pressure  72 ,  75 , or  78 . 
     In the example of the image illustrated in  FIG. 15 , it can be seen that the discrepancy or deviation occurs between the standard pressure  71  related to the blood removing catheter  5  and the actual pressure  72  related to the blood removing catheter  5 . On the other hand, it can be seen that there is no discrepancy or deviation between the standard pressure  74  related to the oxygenator  2  and the actual pressure  75  related to the oxygenator  2 , between the standard pressure  77  related to the blood feeding catheter  6  and the actual pressure  78  related to the blood feeding catheter  6 , and between the standard head  82  of the centrifugal pump  3  and the actual head  83  of the centrifugal pump  3 . As a result, in the example of the image illustrated in  FIG. 15 , the operator or the like can grasp that there is a “possibility of clogging of the blood removing catheter  5 ” due to the distal end of the blood removing catheter  5  coming into contact with the blood vessel wall or there is a “possibility of a kink of the blood removal tube  11 ” as a suspicion of blood removal failure. 
     Next, a description will be given with reference to the drawings regarding control executed as the computer  51  of the extracorporeal circulation management device  10  according to the present embodiment reads the program  31  (extracorporeal circulation management program) stored in the storage unit  30 .  FIGS. 16 and 17  are flowcharts illustrating examples of the control executed by the computer of the extracorporeal circulation management device according to the present embodiment. 
     First, in step S 11 , the control unit  40  stores, for example, the expected flow rate  66 , input by the operator or the like in response to the operator&#39;s operation or the like on the touch panel  52 , in the expected flow rate storage unit  32 . Alternatively, the control unit  40  stores the expected flow rate  66 , calculated by the standard flow rate calculation unit  47  using patient information (for example, height, weight, and the like) input by the touch panel  52  in response to the operator&#39;s operation on the touch panel  52  and the standard information  334  related to the circulation circuit  1 R stored in the standard information storage unit  33 , in the expected flow rate storage unit  32 . Subsequently, in step S 12 , the standard pressure calculation unit  431  related to the blood removing catheter  5  refers to the standard information  331  related to the blood removing catheter  5  stored in the standard information storage unit  33  and calculates the standard pressure  71  related to the blood removing catheter  5  based on the expected flow rate  66  stored in the expected flow rate storage unit  32 . 
     Subsequently, in step S 13 , the standard pressure calculation unit  432  related to the oxygenator  2  refers to the standard information  332  related to the oxygenator  2  stored in the standard information storage unit  33  and calculates the standard pressure  74  related to the oxygenator  2  based on the expected flow rate  66  stored in the expected flow rate storage unit  32 . Subsequently, in step S 14 , the standard pressure calculation unit  433  related to the blood feeding catheter  6  refers to the standard information  333  related to the blood feeding catheter  6  stored in the standard information storage unit  33  and calculates the standard pressure  77  related to the blood feeding catheter  6  based on the expected flow rate  66  stored in the expected flow rate storage unit  32 . 
     Incidentally, the order of the processes described above with respect to steps S 12  to S 14  is not particularly limited. For example, the processes described above with respect to steps S 12  to S 14  may be executed at the same time. Alternatively, the processes described above with respect to steps S 14 , S 13 , and S 12  may be executed in this order. 
     Subsequently, in step S 15 , the control unit  40  acquires the actual flow rate  67  from the flow rate measurement unit  24  through the communication unit  53 . Then, in step S 16 , the actual pressure calculation unit  441  related to the blood removing catheter  5  acquires an actual pressure (actually measured value) from the first pressure sensor  21  through the communication unit  53 , and calculates the actual pressure  72  related to the blood removing catheter  5  based on the actual pressure measured by the first pressure sensor  21  and the actual flow rate  67  acquired from the flow rate measurement unit  24 . Specifically, the actual pressure calculation unit  441  related to the blood removing catheter  5  calculates a value, obtained by subtracting a blood pressure (for example, central venous pressure (CVP)) displayed on the biological monitor  15  from an actually measured value measured by the first pressure sensor  21 , as a pressure loss that actually occurs in the blood removing catheter  5 . 
     Then, in step S 17 , the actual pressure calculation unit  442  related to the oxygenator  2  acquires an actual pressure (actually measured value) from each of the second pressure sensor  22  and the third pressure sensor  23  through the communication unit  53 , and calculates the actual pressure  75  related to the oxygenator  2  based on the actual pressure measured by the second pressure sensor  22 , the actual pressure measured by the third pressure sensor  23 , and the actual flow rate  67  acquired from the flow rate measurement unit  24 . Specifically, the actual pressure calculation unit  442  related to the oxygenator  2  calculates a value, obtained by subtracting an actually measured value measured by the second pressure sensor  22  from an actually measured value measured by the third pressure sensor  23 , as a pressure loss that actually occurs in the oxygenator  2 . 
     Subsequently, in step S 18 , the actual pressure calculation unit  443  related to the blood feeding catheter  6  acquires the actual pressure (actually measured value) from the third pressure sensor  23  through the communication unit  53 , and calculates the actual pressure  78  related to the blood feeding catheter  6  based on the actual pressure measured by the third pressure sensor  23  and the actual flow rate  67  acquired from the flow rate measurement unit  24 . Specifically, the actual pressure calculation unit  443  related to the blood feeding catheter  6  calculates a value, obtained by subtracting the actually measured value measured by the third pressure sensor  23  from a blood pressure (for example, average blood pressure) displayed on the biological monitor  15 , as a pressure loss that actually occurs in the blood feeding catheter  6 . 
     Subsequently, in step S 19 , the differential flow rate calculation unit  45  calculates the differential flow rate  68  representing the difference between the expected flow rate  66  stored in the expected flow rate storage unit  32  and the actual flow rate  67  acquired from the flow rate measurement unit  24 . Subsequently, in step S 21 , the differential pressure calculation unit  461  related to the blood removing catheter  5  calculates the differential pressure  73  related to the blood removing catheter  5  representing the difference between the standard pressure  71  related to the blood removing catheter  5  calculated by the process described above with respect to step S 12  and the actual pressure  72  related to the blood removing catheter  5  calculated by the process described above with respect to step S 16 . 
     Subsequently, in step S 22 , the differential pressure calculation unit  462  related to the oxygenator  2  calculates the differential pressure  76  related to the oxygenator  2  representing the difference between the standard pressure  74  related to the oxygenator  2  calculated by the process described above with respect to step S 13  and the actual pressure  75  related to the oxygenator  2  calculated by the process described above with respect to step S 17 . Subsequently, in step S 23 , the differential pressure calculation unit  463  related to the blood feeding catheter  6  calculates the differential pressure  79  related to the blood feeding catheter  6  representing the difference between the standard pressure  77  related to the blood feeding catheter  6  calculated by the process described above with respect to step S 14  and the actual pressure  78  related to the blood feeding catheter  6  calculated by the process described above with respect to step S 18 . 
     Subsequently, in step S 24 , the display processing unit  41  displays all the expected flow rate  66 , the actual flow rate  67 , the differential flow rate  68 , the standard pressure  71  related to the blood removing catheter  5 , the actual pressure  72  related to the blood removing catheter  5 , the differential pressure  73  related to the blood removing catheter  5 , the standard pressure  74  related to the oxygenator  2 , the actual pressure  75  related to the oxygenator  2 , the differential pressure  76  related to the oxygenator  2 , the standard pressure  77  related to the blood feeding catheter  6 , the actual pressure  78  related to the blood feeding catheter  6 , and the differential pressure  79  related to the blood feeding catheter  6  simultaneously and in parallel on the external monitor  16  as one display unit. 
     Subsequently, in step S 25 , the control unit  40  determines whether or not an absolute value of at least any of the differential flow rate  68 , the differential pressure  73  related to the blood removing catheter  5 , the differential pressure  76  related to the oxygenator  2 , and the differential pressure  79  related to the blood feeding catheter  6  is equal to or larger than a predetermined value. When the absolute value of at least any of the differential flow rate  68 , the differential pressure  73  related to the blood removing catheter  5 , the differential pressure  76  related to the oxygenator  2 , and the differential pressure  79  related to the blood feeding catheter  6  is equal to or larger than the predetermined value (step S 25 : YES), the notification processing unit  42  refers to the warning information stored in the warning information storage unit  35 , and notifies the external monitor  16  of the warning information. As a result, the operator or the like can more easily grasp occurrence of a discrepancy or deviation between the expected flow rate  66  and the actual flow rate  67 , and further grasp a location of the circulation circuit  1 R where the discrepancy or deviation between the standard pressure  71 ,  74 , or  77  and the actual pressure  72 ,  75 , or  78  has occurred and more easily grasp that a cause of circulation failure exists near the location. Incidentally, an example of the warning information notification of which is provided by the notification processing unit  42  is the same as that described above with respect to  FIG. 12 . 
     On the other hand, when the absolute value of at least any of the differential flow rate  68 , the differential pressure  73  related to the blood removing catheter  5 , the differential pressure  76  related to the oxygenator  2 , and the differential pressure  79  related to the blood feeding catheter  6  is not equal to or larger than the predetermined value (step S 25 : NO), the control unit  40  determines in step S 27  whether or not the extracorporeal circulation is completed. In addition, in step S 27  following step S 26 , the control unit  40  determines in step S 27  whether or not the extracorporeal circulation is completed. 
     When the extracorporeal circulation is not completed (step S 27 : NO), the processing returns to step S 15 , and the control unit  40  acquires the actual flow rate  67  from the flow rate measurement unit  24  through the communication unit  53 . On the other hand, when the extracorporeal circulation is completed (step S 27 : YES), the control unit  40  ends the execution of the program  31  related to the extracorporeal circulation. 
     According to the program  31  (extracorporeal circulation management program) of the present embodiment, the operator or the like can easily grasp a discrepancy or deviation between the expected flow rate  66  of blood in the circulation circuit  1 R and the actual flow rate  67  of the blood actually flowing in the circulation circuit  1 R by confirming the external monitor  16 . In addition, the operator or the like can easily grasp a discrepancy or deviation between each of the standard pressures  71 ,  74 , and  77  calculated based on the expected flow rate  66  and each of the actual pressures  72 ,  75 , and  78  related to the respective devices (the blood removing catheter  5 , the oxygenator  2 , and the blood feeding catheter  6 ) by observing the external monitor  16 . Therefore, when there is the discrepancy or deviation between the expected flow rate  66  and the actual flow rate  67 , the operator or the like can easily grasp the occurrence of the discrepancy or deviation between the expected flow rate  66  and the actual flow rate  67  and grasp a location of the circulation circuit  1 R where the discrepancy or deviation between the standard pressure  71 ,  74 , or  77  and the actual pressure  72 ,  75 , or  78  has occurred and easily grasp that a cause of circulation failure exists near the location by observing the external monitor  16 . That is, the location of the circulation circuit  1 R where the discrepancy or deviation between the standard pressure  71 ,  74 , or  77  and the actual pressure  72 ,  75 , or  78  has occurred corresponds to a portion where the pressure measurement unit  20  is provided or a portion of each device provided near the pressure measurement unit  20 . In this manner, the operator or the like can easily grasp the cause of the circulation failure in the extracorporeal circulation. In addition, the same effects as those described above can be obtained with respect to  FIGS. 13 and 14 . 
     The embodiments of the present invention have been described above. However, the present invention is not limited to the above embodiments, and various modifications can be made within a range not departing from the scope of claims. The configurations of the above embodiments can be partially omitted or arbitrarily combined so as to be different from the above configurations.