Patent Publication Number: US-2022226149-A1

Title: Dermatological treatments and systems employing cooling, topicals, and/or abrasion

Description:
CROSS-REFERENCES TO RELATED APPLICATIONS 
     This application claims the benefit of U.S. Provisional Application No. 63/139,450, filed on Jan. 20, 2021, and entitled “DERMATOLOGICAL TREATMENTS AND SYSTEMS EMPLOYING COOLING, TOPICALS, AND/OR ABRASION”, the entirety of which is hereby incorporated by reference herein. 
    
    
     BACKGROUND 
     Cryotherapy is the local or general use of cold in medical therapy. Cryotherapy can include the controlled freezing of biological tissue, which controlled freezing of biological tissue, such as skin tissue, can produce various effects. Certain tissue freezing procedures and devices, such as conventional cryoprobes, can cause severe freezing of tissue and generate cellular and visible skin damage. 
     There is a demand for cosmetic products that can change the appearance of skin or otherwise controllably affect skin appearance and/or pigmentation. This can include lightening or darkening of the skin, improving evenness of skin tone, minimizing wrinkles, or the like. For example, it may be desirable to lighten the overall complexion or color of a region of skin to alter the general appearance for cosmetic reasons. Also, lightening of particular hyperpigmented regions of skin, such as freckles, ‘café au lait’ spots, melasma, or dark circles under the eyes that may result from excessive local amounts of pigment in the skin, may also be desirable for cosmetic reasons. Hyperpigmentation can result from a variety of factors such as UV exposure, aging, stress, trauma, inflammation, etc. Such factors can lead to an excess production of melanin, or melanogenesis, in the skin by melanocytes, which can lead to formation of hyperpigmented areas. Such hyperpigmented areas are typically associated with excess melanin within the epidermis and/or dermal-epidermis junction. However, hyperpigmentation can also result from excess melanin deposited within the dermis. 
     Hypopigmentation of skin tissue has been observed as a side effect in response to temporary cooling or freezing of the tissue, such as may occur during conventional cryosurgery procedures. Loss of pigmentation following skin cooling or freezing may result from decreased melanin production, decreased melanosome production, destruction of melanocytes, or inhibited transfer or regulation of melanosome into the keratinocytes in the lower region of the epidermal layer. The resultant hypopigmentation may be long-lasting or permanent. However, it has also been observed that some of these freezing procedures can generate regions of hyperpigmentation (or skin darkening) of skin tissue. The level of increase or decrease in pigmentation may be dependent upon certain aspects of the cooling or freezing conditions, including the temperature of the cooling treatment, and the length of time the tissue is maintained in a frozen state. 
     Improved hypopigmentation treatments, devices, and systems have been developed to improve the consistency of skin freezing and the overall hypopigmentation consistency. For example, it has been observed that moderate degrees of freezing (e.g., −4 to −30 degrees Celsius) at shorter time frames (e.g., 30 to 60 seconds) can produce particular dermatological effects, such as affecting the expression of skin pigmentation (e.g., hypopigmentation). Cryotherapy can be provided using a variety of techniques including the direct application of a cryogen spray to the skin of the patient or the application of a cooled probe or plate to the skin of the patient. Exemplary methods and devices are described in: U.S. Patent Publication No. 2011/0313411, filed on Aug. 7, 2009, and entitled “METHOD AND APPARATUS FOR DERMATOLOGICAL HYPOPIGMENTATION”; U.S. Patent Publication No. 2014/0303696, filed on Nov. 16, 2012, and entitled “METHOD AND APPARATUS FOR CRYOGENIC TREATMENT OF SKIN TISSUE”; U.S. Patent Publication No. 2014/0303697, filed on Nov. 16, 2012, and entitled “METHOD AND APPARATUS FOR CRYOGENIC TREATMENT OF SKIN TISSUE”; U.S. Patent Publication No. 2015/0223975, filed on Feb. 12, 2015, and entitled “METHOD AND APPARATUS FOR AFFECTING PIGMENTATION OF TISSUE”; U.S. Patent Publication No. 2017/0065323, filed on Sep. 6, 2016, and entitled “MEDICAL SYSTEMS, METHODS, AND DEVICES FOR HYPOPIGMENTATION COOLING TREATMENTS”; U.S. Pat. No. 10,765,467, filed on Sep. 6, 2016, and entitled “Medical Systems, Methods, And Devices For Hypopigmentation Cooling Treatments”; and U.S. Patent Publication No. 2017/0348143, filed on Jun. 2, 2017, and entitled “MEDICAL METHODS AND SYSTEMS FOR SKIN TREATMENT”, the entirety of each of which is hereby incorporated by reference herein. 
     While the treatment of skin or a localized lesion can be accomplished with cryotherapy, it may be desirable to provide improved methods, systems, and devices for cryotherapy. In particular, improved designs, controls and parameters associated with cryogen delivery to achieve consistent and reliable skin freezing and desired skin treatment effect may be of benefit. Accordingly, improved dermatological treatments and systems employing cooling, topicals, and/or abrasion are desirable. 
     BRIEF SUMMARY 
     Embodiments disclosed herein relate to dermatological treatments and systems employing cooling, topicals, and/or abrasion. This can include a system to deliver and/or control the delivery of a cooling treatment. The system can include hardware and/or software features to facilitate delivery of such cooling treatment. This can include a handpiece including a cold plate. One or several handpiece tips can be coupled to the cold plate to provide a desired treatment. These handpiece tips can include, for example, a smooth tip, a textured tip, and/or a suspension assembly tip, which suspension assembly tip can be smooth or textured. 
     The suspension assembly tip can include a suspension and a suspension tip. The suspension can couple to the cold plate and can couple to the suspension tip. The suspension can suspend the suspension tip such that the suspension tip can move with respect to the cold plate. This movement can smooth forces applied to a patient via suspension tip. Further, the suspension can thermally isolate and/or thermally coupled the suspension tip to the cold plate. This can selective thermal isolation and/or thermal coupling can facilitate broader use of the handpiece for freezing, cooling, and/or other treatments. 
     One aspect relates to a system for delivering a cooling treatment to an area of skin of a patient. The system includes a cold plate and a suspension assembly tip selectively coupleable to the cold plate. The suspension assembly tip can include a suspension tip, and a suspension. 
     In some embodiments, the system includes a handpiece coupled to the cold plate. In some embodiments, the handpiece includes a cooler that can control a temperature of the cold plate. In some embodiments, the handpiece further includes a button that can receive a user input indicative of initiation of a treatment. 
     In some embodiments, the handpiece further includes a feature that can detect contacting of the cold plate to skin of the patient. In some embodiments, the feature that can detect contacting of the cold plate to the skin of the patient can be a capacitive touch sensor. In some embodiments, the feature that can detect contacting of the cold plate to the skin of the patient can be a temperature sensor. 
     In some embodiments, the system can include a controller communicatively coupled to the cooler. In some embodiments, the controller can control operation of the cooler to control the temperature of the cold plate. In some embodiments, the controller can control operation of the cooler according to stored treatment instructions. 
     In some embodiments, the cold plate includes a distal protrusion, a camming surface extending proximally and radially away from a proximal end of the distal protrusion, a retention depression connecting to a proximal end of the camming surface. In some embodiments, the camming surface is at least partially conical. In some embodiments, the cold plate further includes a plurality of axial grooves located around a perimeter of a junction of the proximal end of the camming surface and the retention depression. In some embodiments, the retention depression extends to a retention depth below the proximal end of the camming surface. In some embodiments, the axial grooves have a groove depth equal to the retention depth. 
     In some embodiments, the suspension tip can be at least one of a smooth tip, and a textured tip. In some embodiments, the suspension tip can have an exterior housing. In some embodiments, the exterior housing includes a contact surface and a base. In some embodiments, the base defines an opening extending into a receptacle defined by an interior wall of the exterior housing of the suspension tip. In some embodiments, the receptacle can receive the suspension. In some embodiments, the suspension tip further comprises a retention groove and a suspension lip. In some embodiments, each of the retention groove and the suspension lip are formed in the receptacle by the interior wall of the exterior housing. In some embodiments, the retention groove is relatively more proximate to the base of the exterior housing than suspension lip. 
     In some embodiments, the suspension comprises a central member located at a top of the suspension, a suspension member array including a plurality of suspension members, and a coupling member array comprising a plurality of coupling members. In some embodiments, each of the suspension members radially extends from a proximal end connected to the central member. In some embodiments, each of the coupling members extends radially and downward from a proximal end connected to the central member. 
     In some embodiments, the central member defines a central receptacle that can receive a portion of the cold plate. In some embodiments, the coupling member array is conical shaped. In some embodiments, a distal end of each of the coupling members includes a coupling head. In some embodiments, at least some of the coupling heads of the coupling members include an external connector that can engage with the retention groove. 
     In some embodiments, at least some of the coupling heads of the coupling members include internal connector that can engage with the cold plate. In some embodiments, the internal connectors can engage with the retention groove of the cold plate. In some embodiments, each of the suspension members engages with the suspension lip. In some embodiments, each of the plurality of suspension members in the suspension member array is located in a common plane. 
     One aspect relates to a suspension assembly tip selectively coupleable to a cold plate. The suspension assembly tip includes a suspension tip including an exterior housing, the exterior housing including a contact surface, an interior surface defining a receptacle within the exterior housing, and a base. In some embodiments, the base defines an opening extending into the receptacle. The suspension assembly tip includes a suspension coupled to the interior surface of the exterior housing. In some embodiments, the receptacle can receive the suspension. 
     In some embodiments, the suspension contact surface of the suspension tip includes at least one of a smooth contact surface, and a textured contact surface. In some embodiments, the suspension tip further includes a retention groove, and a suspension lip. In some embodiments, each of the retention groove and the suspension lip are formed in the interior surface of the exterior housing. In some embodiments, the retention groove is relatively more proximate to the base of the exterior housing than suspension lip. 
     In some embodiments, the suspension includes a central member located at a top of the suspension, a suspension member array including a plurality of suspension members, and a coupling member array comprising a plurality of coupling members. In some embodiments, each of the suspension members radially extends from a proximal end connected to the central member. In some embodiments, each of the coupling members extends radially and downward from a proximal end connected to the central member. 
     In some embodiments, the central member defines a central receptacle. In some embodiments, the coupling member array is conical shaped. In some embodiments, a distal end of each of the coupling members can include a coupling head. In some embodiments, at least some of the coupling heads of the coupling members can include an external connector that can engage with the retention groove. In some embodiments, at least some of the coupling heads of the coupling members include an internal connector that can engage with the cold plate. In some embodiments, each of the suspension members engages with the suspension lip. In some embodiments, each of the plurality of suspension members in the suspension member array is located in a common plane. 
     One aspect of the present disclosure relates to a method of delivering a skin cooling treatment to an area of skin of a patient. The method can include receiving a card within a card reader of a cooling treatment system. The cooling treatment system can include a display, a chiller located in a housing, and a handpiece flexibly coupled to the housing. The handpiece can include a cooler for cooling a cold plate of the handpiece. The method can include identifying treatment instructions stored on the card, the treatment instructions including at least one temperature profile identifying a plurality of temperatures and an associated time for ramping to and/or for maintaining each of the plurality of temperatures, launching a graphical user interface (GUI) corresponding to the identified treatment, identifying a step in a plurality of steps in the identified treatment, controlling the GUI to guide the user though performing user actions of the step in the identified treatment, setting a temperature of the cold plate to a first temperature of the temperature profile, and controlling the GUI to display a countdown timer upon receipt of an indication of initiation of delivery of treatment of the identified step. It some embodiments, and subsequent to setting a temperature of the cold plate to a first temperature, the cold-plate can be pre-cooled until the set temperature of the cold plate is achieved. 
     In some embodiments, the step can be a freezing step. In some embodiments, a second step can be a cooling step. In some embodiments, a cooling step can comprise a step wherein a temperature of the skin being treated is lowered. In some embodiments, the cooling step can include lowering the temperature of the skin being treated such that ice crystallization occurs in the skin being treated. In some embodiments, a third step can be a dwell step. In some embodiments, a fourth step can be a rewarming step. In some embodiments, this can include rewarming of the skin to a temperature up to, for example, 50° C., 45° C., 40° C., 35° C., 30° C., between 30° C. and 50° C., between 35° C. and 45° C., or the like. 
     In some embodiments, controlling the GUI to guide the user through performing user actions of the next step can include identifying at least one topical, and directing the application of the topical to the area of skin of the patient. In some embodiments, controlling the GUI to guide the user through performing user actions of the next step can include directing the user to cool the area of skin of the patient via the handpiece. In some embodiments, directing the user to cool the area of skin of the patient via the handpiece can include directing the user to contact the area of skin of the patient with the cold plate, and depress a button to indicate initiation of delivery of treatment of the identified next step. In some embodiments, directing the user to cool the area of skin of the patient via the handpiece can include directing the user to connect a treatment tip, also referred to herein as a cooling tip, to the cold plate of the handpiece, contact the area of skin of the patient with the treatment tip connected to the cold plate, and depress a button to indicate initiation of delivery of treatment of the identified next step. 
     In some embodiments, the treatment tip can be at least one of a smooth tip, and a textured tip. In some embodiments, the cold plate can include a distal protrusion, a camming surface extending proximally and radially away from a proximal end of the distal protrusion, and a retention depression connecting to a proximal end of the camming surface. In some embodiments, the camming surface is at least partially conical. 
     In some embodiments, the treatment tip includes an exterior housing, and a retention feature located within the exterior housing. In some embodiments, the retention feature can be retained within the retention depression to thereby connect the treatment tip to the cold plate. In some embodiments, the retention feature can be a rubber O-ring. In some embodiments, the cold plate further includes a plurality of axial grooves located around a perimeter of a junction of the proximal end of the camming surface and the retention depression. In some embodiments, the plurality of axial grooves prevent sealing of the O-ring to the cold plate when connecting the treatment tip to the cold plate. 
     In some embodiments, setting a temperature of the cold plate to a first temperature of the temperature profile includes controlling the chiller to cool a coolant to a coolant temperature within a target range, circulating the coolant through the handpiece, and controlling a cooler within the handpiece to cool the cold plate to a desired cold plate temperature. In some embodiments, the cooler can be a thermoelectric cooler. In some embodiments, controlling the cooler within the handpiece to cool the cold plate to a desired cold plate temperature can include transferring heat from the cold plate to the coolant circulating through the handpiece with the thermoelectric cooler. In some embodiments, the chiller can include a coolant circulation system, a heat exchanger, and a refrigeration unit coupled via the heat exchange to the coolant circulation system. In some embodiments, the refrigeration unit can cool the coolant in the coolant circulation system. In some embodiments, the chiller further includes a heating unit that can heat coolant in the coolant circulation system. 
     In some embodiments, the method can include receiving a termination request; and cancelling the treatment. In some embodiments, the termination request is received from the user. In some embodiments, the method includes generating a termination request, and cancelling the treatment. In some embodiments, the termination request is generated by a processor of the cooling treatment system in response to a detected temperature. In some embodiments, the detected temperature can be at least one of a temperature of the cold plate, a temperature of the chiller, or a temperature of the cooler. In some embodiments, cancelling the treatment includes controlling the cooler to rewarm the cold plate. In some embodiments, after receiving the termination request, the cold plate is heated. In some embodiments, the cold plate can be heated via control of at least one of the chiller and the cooler. In some embodiments, cancelling the treatment includes heating the cold plate. In some embodiments, heating the cold plate includes controlling at least one of: the chiller; and the cooler to heat the cold plate. 
     In some embodiments, the method can further include determining a value of a count of available treatment cycles associated with the card, receiving an instruction from user to provide a treatment, and starting the treatment when the value indicates that at least one treatment is available. In some embodiments, the method can further include decrementing the value of the count of available treatment cycles upon starting the treatment. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1  is a schematic illustration of one embodiment of a cooling treatment system. 
         FIG. 2  is a schematic illustration of electrical components of the cooling treatment system. 
         FIG. 3  is a perspective view of one embodiment of the cooling treatment system including a tabletop console. 
         FIG. 4  is a back view of one embodiment of the cooling treatment system including a tabletop console. 
         FIG. 5  is a perspective view of one embodiment of the cooling treatment system with cord in a boom. 
         FIG. 6  is a perspective view of a floor-based cooling treatment system. 
         FIG. 7  is a perspective view of one embodiment of the handpiece. 
         FIG. 8  is a perspective view of a cold plate. 
         FIG. 9  is a side view of a cold plate. 
         FIG. 10  is a perspective view of one embodiment of a smooth tip. 
         FIG. 11  is a side view of one embodiment of a smooth tip. 
         FIG. 12  is a section view of one embodiment of a smooth tip. 
         FIG. 13  is a perspective view of one embodiment of a textured tip. 
         FIG. 14  is a side view of one embodiment of a textured tip. 
         FIG. 15  is a section view of one embodiment of a textured tip. 
         FIG. 16  is section view of one embodiment of an assembled suspension assembly tip. 
         FIG. 17  is a section view of one embodiment of a suspended tip. 
         FIG. 18  is a side view of a suspension structure. 
         FIG. 19  is a perspective view of one embodiment of a suspension structure. 
         FIG. 20  is a schematic illustration of one embodiment of the chiller. 
         FIG. 21  is a flowchart illustrating one embodiment of a process for delivering a skin cooling treatment to a patient. 
         FIG. 22  is one embodiment of a treatment profile. 
         FIG. 23  is a depiction of a GUI indicating readiness to receive an artifact. 
         FIG. 24  is a depiction of a GUI launched in connection with a restore treatment. 
         FIG. 25  is a depiction of a GUI directing a user to place a treatment tip on the cold plate. 
         FIG. 26  is a depiction of a GUI directing a user to depress a button on the handpiece. 
         FIG. 27  is a depiction of a GUI directing a user to apply the treatment tip to the patient&#39;s skin. 
         FIG. 28  is a depiction of a GUI directing a user for a dwell time. 
         FIG. 29  is a depiction of a GUI launched in connection with a freeze treatment. 
         FIG. 30  is a depiction of a GUI directing a user to depress a button on the handpiece. 
         FIG. 31  is a depiction of a GUI directing a user to apply the cold plate to the patient&#39;s skin. 
         FIG. 32  is a depiction of a GUI directing a user to maintain the application of the cold plate to the patient&#39;s skin. 
         FIG. 33  is a graph depicting measured improvements of a patient&#39;s skin subsequent to receiving a treatment described herein. 
         FIG. 34  includes a photo of a patient before receiving the treatment described herein and a photo of a patient after receiving the treatment described herein. 
     
    
    
     DETAILED DESCRIPTION 
     Cooling based treatments are frequently used to address a wide range of health and aesthetic issues. These issues can include, for example, the ablation of benign lesions such as, for example, acne—vulgaris, cystic; acne keloidalis; adenoma sebaceum; alopecia areatea; angiokeratomas; angiokeratoma of Fordyce; atypical fibroxanthoma; cherry angiomas; 
     chonrodermatitis nodularis helicis; chromoblastomycosis; clear cell acanthoma; condyloma acuminatum; dermatofibroma; disseminated superficial actinic porokeratosis; elastosis perforans serpiginosa; epidermal nevus; erosive adenomatosis of the nipple; folliculitis keloidalis; granuloma annulare; granuloma faciale; granulomaa pyogenicum; hemangioma; herpes labialis; idiopathic guttate hypomelanosis; Kyrle&#39;s disease; leishmaniasis; lentigines; lentigo simplex; 
     lichen sclerosus et atrophicus of vulva; lupus erythematosus; lymphangioma; lymphocytoma cutis; molluscum contagiosum; mucocele; myxoid cyst; orf; porokeratosis plantaris discreta; porokeratosis of Mibelli; prurigo nodularis; pruritus ani; psoriasis; rhinophyma; rosacea; sarcoid; sebaceous hyperplasia; seborrheic keratosis; solar lentigo; syringoma; trichiasis; trichoepithelioma; varicose veins; venous lakes; verrucae—periungual, plane, vulgaris, filiform, plantar; xanthoma; acne scar; keloids; cutaneous horn; hypertrophic scar; ingrown toenail; skin tags; tattoos; freckles; spider naevus; capillary haemangioma; cavernous haemangioma; milia; trichillemmal cyst; steatocystoma multiplex; hidrocystoma; acrokeratosis veruciformis; dermatosis papulose nigra; hyperkeratosis naevoid of nipple; benign lichenoid keratosis; angiofibromas; and angiomas. In some embodiments, cooling based treatments can be used to treat pre-malignant skin conditions such as, for example: actinic keratosis; leukoplakia; Bowen disease; erythroplasia of Quyrat; keratoacanthoma; and lentigo maligna, and can be used to treat malignant skin conditions such as, for example: basal cell carcinoma; Kaposi sarcoma; squamous cell carcinoma; and melanoma. 
     Some of these treatments have been specifically designed to cause skin healing, achieve a desired cosmetic benefit, and/or to change a color of the skin via the creation of skin lightening or of skin darkening. This can include minimizing lines and/or wrinkles, improving skin roughness, improving evenness of skin tone, or the like. 
     Maximizing the beneficial impact of treatments on skin can be complicated and may include multiple steps, which steps can be complex. More specifically, this can include application of one or several topicals, which can include one or several fluids, pastes, creams, serums, emollients, or the like, performing one or several skin manipulations or massages, applying one or several cooling or freezing treatments, and/or the like. The cooling or freezing treatments can include cooling treated skin to specific temperatures and/or temperature ranges, and in some instances can include maintaining those temperatures and/or temperature ranges for a predetermined time and/or range of times. In some instances, the effectiveness of a treatment depends at least in part on the consistency with which this treatment is applied. 
     The present disclosure relates to systems, devices, and methods that improve the delivery of a treatment. In some embodiments, this can include the delivery of a treatment for medical or cosmetic purposes. This can include, for example, to: change a color of the skin such as by causing skin lightening or darkening; ablate a lesion; improve skin tone; minimize lines and wrinkles; and/or facilitate skin healing. 
     With reference now to  FIG. 1 , a schematic illustration of one embodiment of a cooling treatment system  100  is shown. The cooling treatment system  100  can include a body  102 , also referred to herein as a housing  102  or as a console  102 . The body  102  can house several of the components of the cooling treatment system  100  including, for example, a display  104 , a reader  106 , a single board computer (“SBC”)  108 , and a controller  110 . The housing  102  can further connect to a boom  103 . 
     The display  104  can comprise desired display, and can be configured to provide information to the user of the cooling treatment system  100 , and in some embodiments, receive inputs from the of the cooling treatment system. In some embodiments, the display can comprise a touch screen. 
     The reader  106  can comprise a feature configured to read information from an artifact  107 . In some embodiments, this artifact  107  can comprise a physical artifact, and in some embodiments, this artifact can comprise a digital token or a non-physical artifact. In some embodiments, the non-physical artifact can, for example, be locally stored or can be remotely stored. In some embodiments, the non-physical artifact can reside on the cloud and/or be accessible via the cloud. 
     This physical artifact  107  can comprise, for example, any object or token, either physical or digital, comprising computer readable treatment instructions and/or information identifying an associated number of remaining treatment cycles associated with the card. In some embodiments, for example, the number of treatment cycles can track the number of remaining times that the artifact  107  may be used in connection with the cooling treatment system  100  to provide a treatment to a patient. When the number of remaining treatment cycles reaches zero, then the artifact, unless its treatment cycles are reloaded, cannot be used in connection with the cooling treatment system  100  to provide further treatments to patients. Thus, in some embodiments, the artifact comprises a count of available treatments, which count can be decremented when a treatment is provided and which count can be increased if/when the artifact is reloaded. In some embodiments, for example, the artifact can be reloaded by a customer purchase, for example, via the internet. In such an embodiment, subsequent to the successful processing of payment, the value of the count of the artifact can be incremented by the number of purchased treatments. 
     These instructions can comprise a plurality of step and associated treatments, a plurality of treatment parameter or conditions, or the like. In some embodiments, for example, treatment instructions can be loaded onto an artifact  107 , and these instructions can be retrievable from the artifact  107  via the reader  106 . In some embodiments, the artifact can comprise, for example, a microprocessor card, also referred to herein as a smart card. The microprocessor card can communicate with the reader  106  via, for example, a contact-based, or contactless communication. In some embodiments, for example, the artifact can include a plurality of contacts, such as found in, for example, a Europay, Mastercard, and Visa chip (EMV chip), which can connect with contacts in the reader  106  to enable reading of the card. In some embodiments, for example, the artifact  107  can contactlessly connect with the reader according to any desired contactless communication standard and/or wireless communication standard. In some embodiments, for example, the artifact  107  can connect to the reader  106  via, for example, NFC, Bluetooth, WiFi, ethernet, or the like. 
     The SBC  108 , which can, for example, comprise a processor, associated memory, drivers, and/or communications buses. The SBC  108  can interface with other components through communications protocols, and specifically can participate in control of some of the components of the cooling treatment system  100 , and specifically of the console  102 . This can include, for example, the display  104 , the reader  106 , chiller  211 , and/or the antenna  226 . In some embodiments, the SBC  108  can support input/output hardware such as, for example, one or several display drivers, interface drivers, USB interface drivers, or the like. 
     The controller  110 , also referred to herein as a processor  110 , can comprise, for example, a microprocessor, such as a microprocessor from Intel® or Advanced Micro Devices, Inc.®, or Texas Instrument, or Atmel, or the like. In some embodiments, the controller  110  can comprise a custom electronics board, which can include features for controlling, for example, the chiller  211  and/or cooler  230 , and hardware monitoring capabilities. 
     The controller and/or processor  110  can be communicatingly coupled with a memory, which memory can be volatile and/or non-volatile and/or can include volatile and/or non-volatile portions. In some embodiments, the memory can include information and/or instructions, which can be executed by the processor  110 . The processor  110  can, according to these instructions, control all or portions of the cooling treatment system  100 . 
     The body  102  can be connected to a handpiece  112  via cord  111 , also referred to herein as cable  111 . The cord  111  can flexibly couple the handpiece  112  to the body  102 . The cord  111  can physically and communicatingly connect the handpiece  112  to the body  102  and/or to components contained in the body  102 . In some embodiments, for example, the cord  111  can include one or several wires, tubes, optical fiber, or the like. In some embodiments, the controller  110  within the body  102  can control and/or communicate with the handpiece  112  via the cord  111 . In some embodiments, coolant from the body  102  can transit to and from the handpiece  112  via the cord. In some embodiments, all or portions of the weight of the cord  111  can be supported by the boom  103 . 
     The handpiece  112  comprises a hand controller  114  and a cold plate  116 , also referred to herein as a handpiece tip  116 , a freeze tip  116 , and/or a freezing tip  116 . The hand controller can comprise, for example, a microprocessor, such as a microprocessor from Intel® or Advanced Micro Devices, Inc.®, or Texas Instrument, or Atmel, or the like. 
     The hand controller  114  can be communicatingly coupled with a memory, which memory can be volatile and/or non-volatile and/or can include volatile and/or non-volatile portions. In some embodiments, the memory can include information and/or instructions, which can be executed by the hand controller  114 . The hand controller  114  can, according to these instructions, control all or portions of the handpiece  112 , and specifically can control a temperature of the cold plate  116 . 
     The cooling treatment system  100  can further include one or several disposable features which can be contained within a case  118 . These features can include one or several tips  119 . Specifically, these tips  119  can include a smooth tip  120  and/or a textured tip  122 . Each of the smooth tip  120  and the textured tip  122  will be discussed at greater length before. In some embodiments, the case  118  can further include an identifier  124 . In some embodiments, the identifier  124  can comprise a SmartChip that can be, for example, located in a lid of the box. 
     The cooling treatment system  100  can further include one or several topical  132 . These one or several topicals  132  can be contained within a case  130 . In some embodiments, case  130  can be separate and distinct from case  118 , and in some embodiments, case  118  and case  130  can comprise a single case. Case  130  can, in some embodiments, contain the artifact  107  and topicals  130  for providing a treatment. For example, the artifact  107  in the case  130  can include instructions executable by the controller  110  and/or the hand controller  114  to provide the treatment. The case  130  can further include topicals for providing this treatment. 
     These topicals can include, for example a gel such as a hydrogel. The hydrogel can comprise water, a thickening agent to increase viscosity and a preservative. The hydrogel may also include an amount of propylene glycol, alcohol, or similar to depress the freezing point below 0 deg. C. The purpose of the gel is to control the freezing point of the gel and therefore influence the freezing point of the skin, improve the heat transfer between the skin and the cold plate and, in the case where the handpiece tip  116  is being swept across the skin, improve the lubricity between the skin and the handpiece tip  116 . 
     These topicals  132  can include, for example, a Molecular Silk Amino Hydrating Cleanser. This can be pH-balanced, hydrating cleansing gel that can infuse the skin with essential moisture and nutrients as it removes daily grime, pollution, SPF and makeup. This topical can be supercharged with multiple hydrators, antioxidants, Phospholipids and Silk Amino Acids for the ultimate conditioning cleanse. In some embodiments, this can include, for example: Silk Amino Acids, which can provide a potent antioxidant that provides trace nutrients and hydrates the skin; Hyaluronic Acid, which can provide concentrated moisture to the skin and can promote the retention of essential moisture while plumping the skin; Organic Safflower Oil which can break down grime, pollution and makeup as it hydrates and nourishes all skin types; Organic Moringa Oil, which can be extremely rich in phytonutrients with excellent reparative benefits, and which can reduce the ill effects of pollution and external impurities on the skin; Ethylated L-Ascorbic Acid, which can be a pure form of L-Ascorbic Acid in ethylated form that is extremely stable, and which can help neutralize complexion-dulling sebum and brightens dull skin; Lecithin Phospholipids, which can be an important source of essential fatty acids to keep the skin supple, and which can form a protective film on the skin&#39;s surface to seal in essential moisture; White Tea, which provides antioxidant protection as it soothes; Lactic Acid, which can be gentler than most AHAs, and which act as a nourishing brightener and hydrates dull skin; and Astaxanthin, which can be potent antioxidant that helps with moisture retention and elasticity, as well as protect skin against damaging UV rays. 
     In some embodiments, these topicals  132  can include a Peel that can comprise a brightening chemical exfoliator for increased skin radiance and luminosity. The Peel can include, in some embodiments: 10.5% Glycolic+Lactic+Salicylic Acid, which can be Powerful alpha hydroxy acids (AHAs) &amp; Salicylic Acid (BHA) and can reduce blemishes and blackheads, refine large pores, speed up cellular renewal, lighten dark spots while increasing hydration and strengthening the skin&#39;s barrier; ethylated L-Ascorbic Acid, which can be a pure form of L-Ascorbic Acid in ethylated form that is extremely stable, and which helps neutralize complexion-dulling sebum and brightens dull skin; and Pomegranate Enzymes, which can regulate sebum-production, promote hydration, brighten, and gently exfoliate skin. 
     In some embodiments, these topicals  132  can include a Molecular Saviour Probiotics Treatment Mist that can be a Multi-tasking skin recovery and brightening spray mist with lasting hydration. This can further be an anti-evaporation complex to ensure this clings to skin. In some embodiments, this topical can include, for example:  Lactobacillus  Ferment+ Lactobacillus  Ferment Lysate Filtrate+Yogurt, which can be potent probiotics that can create a healthily balanced skin flora and reduce the appearance of imperfections and redness; 5% Niacinamide, which can improve the appearance of large pores and lightens discoloration and can improves skin wellness and its ability to retain moisture; Heavy water, which can be a special water molecule that Is heavier than regular water so It withstands traditional evaporation, and the mist of Heavy water can be designed to cling to your skin cells Instead of simply vanishing; Zinc PCA, which can be a potent mineral that promotes skin wellness; Silver, which can be a potent mineral that reduces the appearance of imperfections and promotes skin wellness; Mango Extract, which can be an antioxidant that promotes hydration, as it effectively reduces appearance of dullness and brightens skin; Ergothioneine, which can be a powerful antioxidant that protects skin from UV radiation, and which reduces sunburns and sun damage; and Acai Berry, a super-food that is abundant in trace nutrients, brightens and is a powerful antioxidant. 
     In some embodiments, these topicals  132  can include a Glacial Calming Recovery Mask that can instantly replenish moisture, soothe, and boost essential microbiome. In some embodiments, this topical can include: Snow Algae, increases hydration in the skin for a more supple complexion, boosts collagen production for improved texture and appearance, and protects skin from environmental damage at a cellular level; IceAwake™, which can visibly improve skin appearance by decreasing wrinkle depth, increasing complexion radiance, and reducing the appearance of fatigue; Vin-up Lift, which can be a resveratrol-based skin tightening ingredient extracted from Swiss ice wine combined with tara gum polysaccharide to minimize fine lines and smooth skin; Organic Safflower Oil, which can be a skin-identical lipid that hydrates and nourishes all skin types; 5% Niacinamide, which can improve the appearance of large pores and lightens dark spots, can improve pores and lighten dark spots, and can improve skin barrier function and its ability to retain moisture; Honey Extract, which can boost the skin microbiome; Beta-Glucan, which can provide profound epidermal hydration and skin soothing; and Multi-Molecular Weight Hyaluronic Acid, provides topical and concentrated moisture and moisture retention to skin while plumping the appearance of fine lines. 
     In some embodiments, these topicals  132  can include a Vitamin C Brighten+Firm Serum. This can, in some embodiments, be a 20% Vitamin C Brighten+Firm Serum. This topical is an antioxidant-rich serum formula that fades dark spots, enhances skin radiance, and protects against sun-induced damage and pollutants while promoting brighter, firmer skin. This topical can include: 20% Ethylated L-Ascorbic Acid, which is a pure form of L-Ascorbic Acid in ethylated form that is extremely stable, and that penetrates deep into the dermis/skin to provide superior antioxidant protection, stimulate collagen production, rebuilds skin barrier and visibly brightens dark spots; 2% Citrus Cells, which can be extracted from oranges, and which actively enhance elasticity and promotes smoother and firmer skin, for a renewed complexion; Glutathione, which is a powerful antioxidant, and which prevents free radical damage and repairs signs of premature skin aging while brightening skin; and Thiotaine, which is a powerful antioxidant and which protects and repairs tired skin while strengthening the skin&#39;s delicate barrier. 
     In some embodiments, these topicals  132  can include a Peptides &amp; Antioxidants Daily Firming Treatment. This can be a daily moisturizer to protect skin against pollution and damage, combat inflammation, firm skin and restore a healthy barrier. This topical can include, for example: Teprenone, which can actively extend telomere health, restores healthy skin barrier, protects DNA and reduces age spots; Marrubium Vulgare Extract, which can enhance softness and smoothness of skin and refine skin texture, this can further help make blackheads less visible, leaving the skin radiant and purified; Palmitoyl Tripeptide-5, which can stimulate the production of collagen, prevent the formation of wrinkles and reduce their appearance, improves skin texture, and rejuvenate and smooth the skin; Palmitoyl Tripeptide-8, which prevents and reverses signs of inflammation, and calms and soothes irritated skin; Tetrahexyldecyl Ascorbate, which is a stable oil-soluble form of Vitamin C that penetrates deep into the skin to stimulate collagen production, brighten dark spots and provide free radical protection; Glutathione, Astaxanthin, Thiotaine, Phospholipids, and Ceramides, which care potent antioxidants that protect and repair tired skin while strengthening the skin&#39;s delicate barrier;  Lactobacillus  Ferment, which are potent probiotics that create a healthily balanced skin flora and strengthen the skin&#39;s natural defenses and reduces the appearance of breakouts and redness; Hydrolyzed Verbascum Thapsus Flower, that protects the skin against harmful light energy sources like UV and blue light; Hyaluronic Acid, which can be low molecular weight Hyaluronic Acid that provides concentrated moisture to the skin, and that promotes the retention of essential moisture; Caffeine, which provides instant tightening and de-puffing and antioxidant protection; Raspberry Seed Oil+Acai Oil, which provide superior antioxidant protection and feeds the skin with essential fatty acids, hydration and trace nutrients; Moringa Extract, which purifies the skin and prevent pollution particles from sticking to the skin and doing damage; and Niacinamide, which brightens skin, improves skin barrier function and its ability to retain moisture. 
     In some embodiments, these topicals  132  can include a RESET Acai &amp; Manuka Honey Nourishing Cleanser. This can be, for example, a pH balanced (pH 4.5), fragrance and sulfate-free creamy cleanser supercharged with Manuka Honey UMF 17+, Acai Oil+Extract, Yogurt and Grapeseed Oil for a nourishing cleanse with every single wash. This can include, for example: Acai Oil+Extract, which can provides superior antioxidant protection and feed the skin with essential fatty acids, hydration and trace nutrients; Grapeseed Oil, which can breaks down grime, pollution and makeup as it hydrates and nourishes all skin types; Yogurt having potent probiotics that create a healthily balanced skin flora, promote cellular renewal, strengthen skin&#39;s natural defenses, and reduces blemishes and redness; and Medical Grade Manuka Honey UMF 17+, which can be sourced from a sustainable bee farm in New Zealand, medical grade Manuka honey provides natural antibacterial properties, reduces inflammation and stimulates cellular repair of damaged skin. 
     In some embodiments, these topicals  132  can include a FOLLOW THE LIGHT Peel. This can be a 20 min brightening peel that hydrates and erases signs of dullness as it brightens and refines the appearance of large pores. This peel can include, for example: 6.5% Glycolic+Lactic+Salicylic Acid, which powerful alpha hydroxy acids (AHAs) &amp; Salicylic Acid reduce blemishes and blackheads, refine large pores, speed up cellular renewal, lighten dark spots while increasing hydration and strengthening the skin&#39;s barrier; Pomegranate Enzymes, which regulate sebum-production, promotes hydration, brightens, and gently exfoliates skin; Hyaluronic Acid+Crosslinked HA, which next-generation pure Hyaluronic Acid provides concentrated moisture to the skin, promotes the retention of moisture that protects, and shield the skin against free radicals and environmental stress; Centella Asiatica, which promote repair and healing, soothes sensitivity, and rebuilds skin barrier; Licorice Root Extract+White Tea, which provide antioxidant protection as it brightens and hydrates dull skin; and Glutathione+Vitamin E+Astaxanthin, which prevents UV damage, recycles Vitamin C, provides skin cells with cellular energy so that they function better, and also protects skin from oxidative and cellular damage. 
     In some embodiments, these topicals  132  can include a PSA Niacinamide Glow Mist. This can be Multi-tasking skin recovery and brightening spray mist with lasting hydration. This can include, for example: Niacinamide, which can improves the appearance of large pores and lightens dark spots, improves pores and lightens dark spots, and improves skin barrier function and its ability to retain moisture; Zinc PCA, which can be a potent mineral that reduces blemishes and promotes skin wellness; Centella Asiatica, which provides antioxidant protection while it soothing and firming skin; and Licorice Root Extract, which provides antioxidant protection as it brightens and hydrates dull skin. 
     In some embodiments, these topicals  132  can include a Glacial Brightening Microbiome Treatment Mask. This mask can instantly replenish moisture, soothe, and boost essential microbiome. This can include, for example: Snow Algae, which can increase hydration in the skin for a more supple complexion, boost collagen production for improved texture and appearance, and protect skin from environmental damage at a cellular level; IceAwake™, which can visibly improve skin appearance by decreasing wrinkle depth, increasing complexion radiance, and reducing the appearance of fatigue; Vin-upLift, which is a resveratrol-based skin tightening ingredient extracted from Swiss ice wine combined with tara gum polysaccharide to minimize fine lines and smooth skin; Organic Safflower Oil, which is a skin-identical lipid that hydrates and nourishes all skin types; Niacinamide, which improves the appearance of large pores and lightens dark spots, improves pores and lightens dark spots, and improves skin barrier function and its ability to retain moisture; Honey Extract, which boosts microbiome; Beta-Glucan, which provides profound epidermal hydration and skin soothing; and Multi-Molecular Weight Hyaluronic Acid, which provides topical and concentrated moisture and moisture retention to skin while plumping the appearance of fine lines. 
     In some embodiments, these topicals  132  can include a LIQUID PANACEA Centella &amp; Kombucha Firming Recovery Booster. This can be a super antioxidant booster supercharged with 6% Kombucha+White Tea, 5% Centella Stem Cells &amp; Extract, Madecassoside and 3% Vitamin E, designed to repair and firm all skin types while reducing signs of premature ageing and fatigue. This can include, for example, 6% Kombucha+White Tea, which potent antioxidants protect, firm and brighten tired skin while strengthening the skin&#39;s delicate barrier and reducing effects of glycation; 5% Centella Stem Cells+Centella Extract, which promote repair and healing, soothe sensitivity, and rebuild skin barrier while improving the appearance of lines and wrinkles; 3% Vitamin E, which is a potent antioxidant that protects and brightens tired skin while strengthening the skin&#39;s delicate barrier; Madecassoside, which is a critical component of Centella Asiatica that stimulates repair and recovery of worn-out skin. 
     In some embodiments, these topicals  132  can include a GIFTED Acai &amp; Sea Buckthorn Vitamin C Glow Oil. In some embodiments, this can be glow-inducing, brightening oil with a smart blend of 6 cold-pressed oils supercharged with 5% Vitamin C, 2% Vitamin E, &amp; CoEnzyme Q10 Complex for visible skin radiance and nourishment. This can include, for example, 5% Vitamin C, which is a stable oil-soluble form of Vitamin C that penetrates deep into the skin to stimulate collagen production, brighten dark spots, and provide free radical protection; 2% Vitamin E, which is a potent antioxidant that protects and brightens tired skin while strengthening the skin&#39;s delicate barrier; Acai Oil, which is rich in vitamins and antioxidants, restores the skin&#39;s elasticity while boosting cell turnover and collagen production to give skin a glowing complexion; Organic Red Raspberry Oil, which is a powerful antioxidant oil that reduces the appearance of age spots and wrinkles to improve skin&#39;s elasticity and suppleness; CoEnzyme Q10, which is a potent antioxidant that acts against oxidative damage and protects skin against photo-ageing by stimulating collagen production; and Grapeseed+Squalane+Sea Buckthorn Oil, which are oils containing more than 100 bioactive nutrients, antioxidants, vitamins and minerals, and which penetrate deep within the skin to nourish and stimulate repair. 
     With reference now to  FIG. 2 , a schematic illustration of electrical components of the cooling treatment system  100  is shown. The body  102  can include controller  110 , which can comprise USB chip  202 . The USB chip  202  can, convert communications to and from USB signals. 
     The controller  110  can receive power from power supply  204 , which is connected to power entry  206 . In some embodiments, power entry  206  can comprise any feature configured to receive power from a source external to the cooling treatment system  100  and deliver that power to the power supply  204 . The power entry  206  can comprise, in some embodiments, a power cord or power plug. 
     The power supply  204  can supply power to the controller  110  and, via the controller  110  to some or all of the powered components of the cooling treatment system  100 . The power supply can comprise an AC/DC converter, which can, for example, receive AC power from the power entry  206  and convert that AC power to DC. In some embodiments, the power supply  204  can comprise a 1000 W AC/24V DC converter. 
     The controller  110  can power, and communicate with a heat load  206  and a temperature sensor  208 . The heat load  206  can comprise a heater configured to heat a portion of the chiller, and specifically configured to heat coolant traveling through the chiller. The heat load  206  can comprise a resistive heater that can, for example, comprise one or several resistive heating elements. The temperature sensor  208  can be configured to sense a temperature within the body  102 , and specifically, a temperature of the heat load  206  and/or of coolant traveling through the heat load  206 . 
     The controller  110  can further power a driver  210 , which can drive one or several components of the cooling treatment system  100  including, for example a fan and/or a cooler. 
     The body  102  can include a chiller  211  which can be configured to chill a coolant to a coolant temperature within a target range. The chiller  211  can include multiple components powered and/or controlled by the controller  110  including, for example, a refrigeration unit  212 , a pump  220 , and a temperature sensor  216 . In some embodiments, the chiller  211  can be cooled by one or several fans  214 , which can be powered by the controller  110 , and a level of the coolant in the chiller  211  can be detected by liquid sensor  218 , which can be a liquid level sensor. In some embodiments, the chiller  211  can comprise a heat exchanger such as for example, a heat exchanger comprising a plurality of fins and a fan configured to blow air across the fins. 
     The controller  110  can provide regulated DC power to the SBC  108 , the display  104 , and the panel  222 . The SBC  108 , can in turn power the reader  106  and the antenna  226 , and can communicate with each of the display  104 , the reader  106 , and the antenna  226 . In some embodiments, these communications can comprise, for example, USB signals. 
     In addition to powering the panel, the controller  110  can maintain a communicating connection with the panel  222  and USB  224 . In some embodiments, the panel  222  can comprise an interface through which the cable  111  can connect to the body  102 . In some embodiments, for example, the cable  111  can be connected to the panel  222  such that a handpiece board  228 , which is a circuit board in the handpiece  112  containing the hand controller  114  is powered and/or communicatingly connected to the controller  110  via the cable  111 . In some embodiments, via the cable  111 , the cooler  230  is powered and/or controlled by the controller  110 . 
     The cooler  230  can be configured to control the cold plate temperature of the cold plate  116 . In some embodiments, the cooler  230  can comprise a thermoelectric cooler (TEC), which can transfer heat energy way from the cold plate  116 . In some embodiments, the cooler  230  can be configured to transfer this heat energy to a reservoir such as, for example, coolant circulated through the handpiece  112  from the chiller  211 . 
     The handpiece  112  can further include a motor  232 , capacitive touch sensor electronics  234 , also referred to herein as a cap touch  234 , one or several temperature sensors  236 , a speaker  238 , and one or several input features  240 . In some embodiments, each of these components of the handpiece  112  can be powered and/or controlled by the controller  110 . 
     The motor  232  can, in some embodiments be configured to provide haptic feedback and/or tissue vibration. In some embodiments, this vibration can be transferred to the tissue being treated. In some embodiments, these vibrations transferred to the tissue being treated can cause and effect on the tissue being treated. In some embodiments, this can include, for example, causing ice nucleation. 
     The cap touch  234  can comprise an electrical circuit that is electrically coupled to the cold plate  116 . The cap touch  234  can include, for example, a capacitive touch sensor. In some embodiments, the cap touch  234  can be configured, such that the cap touch  234  senses a change in capacitance when the cold plate  116 , or one of the tips  119  coupled to the cold plate  116 , comes into contact with skin or is removed from contact with the skin. In some embodiments, this can enable an automatic start of treatment by determining when the handpiece  112  contacts the patient&#39;s skin or end of treatment as it is removed from the patient&#39;s skin. In some embodiments, and as a result to the detection of contact of the handpiece tip  116  with the patient&#39;s skin, the countdown time can be triggered. 
     In some embodiments in which a freeze or a cooling treatment is being provided, the cap touch  234  can detect when the cold plate  116 , or one of the tips  119  coupled to the cold plate  116 , comes into contact with skin. In such embodiments, the countdown timer can be started for that treatment step when contact is detected. In some embodiments in which dwell time is being provided, the cap touch  234  can detect when the cold plate  116 , or one of the tips  119  coupled to the cold plate  116 , is removed from contact with skin. In such an embodiment, the countdown timer can be started for the dwell time when the removal from contact is detected. 
     The temperature sensor(s)  236  can be configured to sense one or several temperatures in the handpiece  112 . This can include, for example, sensing one or several temperatures of the cold plate  116  and/or one or several temperatures of the handpiece  112  such as, for example, a temperature of the cooler  230 . In some embodiments, based on the sensed temperatures, the cooler  230  can increase or decrease its cooling of the cold plate  116 . 
     The handpiece  112  further includes the speaker  238  and controls  240 . The speaker  238  can comprise an output device configured to provide information to the user of the cooling treatment system  100 . The controls  240  can comprise one or several input features, and specifically one or several buttons. In some embodiments, the user can manipulate the controls  240  to provide one or several inputs to the cooling treatment system  100 , and the cooling treatment system  100  can provide information to the user via the speaker  238 . 
       FIGS. 3 and 4  show views of one embodiment of the cooling treatment system  100 , and specifically of a tabletop embodiment of the cooling treatment system  100 . With reference now to  FIG. 3 , a perspective view of one embodiment of the cooling treatment system  100  is shown. As seen, the cooling treatment system  100  includes the body  102 , the display  104 , and the reader  106 . In the embodiment of  FIG. 3 , the reader  106  comprises a slot configured to receive the artifact  107 , and specifically configured to receive a card such as a microprocessor card. The cooling treatment system  100  further includes a retention receptacle  300 . The retention receptacle is configured to receive a portion of the handpiece  112  to hold, fix, and/or retain the handpiece  112 . The cooling treatment system  100  further includes handles  302 . In some embodiments, the handles  302  include a first handle located on a first side of the body  102  and a second handle located on a second, opposite side of the body  102 . The handles  302  can be positioned such that a person can insert their fingers into the handles  302  and remove their fingers from the handles  302  when the body  102  is positioned on a flat surface. 
     With reference now to  FIG. 4 , a back view of one embodiment of the cooling treatment system  100  is shown. As seen, the cable  111  and the handpiece  112  are mounted to the body  102 , and specifically, are mounted via a plurality of mounting brackets  400  to the body  102  of the cooling treatment system  100 . 
     With reference now to  FIG. 5 , a perspective view of one embodiment of the cooling treatment system  100  is shown. The cooling treatment system  100  includes the body  102 , the boom  103 , the display  104 , and the reader  106 . As seen in  FIG. 5 , the cable  111  extends through the boom  103  and is supported and/or partially supported by the boom  103 . The handpiece  112  is connected to the side of the body  102  via, although not visible, the retention receptacle  300 . 
     With reference now to  FIG. 6 , a perspective view of another embodiment of cooling treatment system  100 , and specifically of a floor-based cooling treatment system  100 . The cooling treatment system  100  includes a wheeled cart  600 . The wheeled cart  600  can, in some embodiments, contain some or all of the components in the body  102  shown in  FIGS. 1 and 2 . As seen in  FIG. 6 , the wheeled cart  600  comprises a plurality of wheels  602  connected to a base  604 . The housing  606  is mounted on the base  604 . The housing  606  can contain, for example, the chiller  211 , the power supply  204 , the power entry  206 , the controller  110 , or the like. 
     A vertical support  608  can extend vertically from the housing  606 . The vertical support  606  can be coupled to and can support the display  104  and the boom  103 . In some embodiments, and as seen in  FIG. 6 , the cable  111  can be coupled to a portion of the vertical support  608 . 
     Although both the embodiments of shown in  FIGS. 3 through 6  are of cooling treatment systems  100 , these embodiments can have different performance attributes. For example, the embodiments of  FIGS. 3 through 5  may provide different cooling levels than the embodiment shown in  FIG. 6 . For example, the embodiment of  FIGS. 3 through 5  may provide cooling/temperature control of the cold plate  116  from −10° C. to +40° C., whereas the embodiment of  FIG. 6  may provide cooling/temperature control of the cold plate from −30° C. to +40° C. In some embodiments, however, all of the embodiments of  FIGS. 3 through 6  may provide cooling/temperature control of the cold plate from −30° C. to +40° C. 
     With reference now to  FIG. 7 , a perspective view of one embodiment of the handpiece  112  is shown. As seen in  FIG. 7 , the handpiece  112  connects to the cable  111 . The handpiece  112  include the cold plate  116 . The cold plate  116  can be controllably cooled to enable the delivery of a cooling and/or freeze treatment. 
     The handpiece  112  further includes an input feature  700 . In some embodiments, and as depicted in  FIG. 7 , this input feature can comprise a button. The handpiece  112  can further include a retention connector  702 . The retention connector  702  can be received by the retention receptacle  300  to thereby couple the handpiece  112  to the console  102  and/or cart  600 . 
     With reference now to  FIG. 8 , a perspective view of the cold plate  116  is shown. The cold plate  116  includes a distal protrusion  800 . The distal protrusion can comprise a cylindrical member extending along axis  801 , and radially around axis  801 . The distal protrusion  800  can comprise a distal end  802  and a proximal end  804 . The distal end  802  can comprise a planar member that can, in some embodiments, extend perpendicular to the axis  801 . 
     The proximal end  804  of the distal protrusion  800  can be coupled to a camming surface  806 . The camming surface  806  can extend proximally and radially away from the proximal end  804  of the distal protrusion  800 . The camming surface  806  can define a truncated cone, specifically, the camming surface comprising the frustum of the truncated cone. Thus, in some embodiments, the camming surface  806  is at least partially conical. 
     As seen in  FIG. 9 , a side view of the cold plate  116 , the camming surface  806  can have a distal end  808  which can connect directly or indirectly to the proximal end  804  of the distal protrusion  800 . In the embodiment of  FIG. 9 , the distal end  808  of the camming surface  806  connects to the proximal end  804  of the distal protrusion via smoothing feature  810 , which can comprise, for example, a blend or round. The camming surface  806  can further comprise a proximal end  812 . 
     The cold plate  116  can further comprise a retention depression  814  extending proximally and radially inward from the proximal end  812  of the camming surface  806 . Thus, a diameter of at least a portion of the retention depression  814  measured from the axis  801  can be less than a diameter of the proximal end  812  of the camming surface  806 . In other words, the retention depression  814  can have a depth below the proximal end  812  of the camming surface  806 . 
     In some embodiments, the cold plate  116  can further comprise a plurality of axial grooves  816  spread around the circumference of the proximal end  812  of the camming surface. In some embodiments, each of these axial grooves  816  can be located at a junction of the proximal end  812  of the camming surface  806  and the retention depression  814 . In some embodiments, each of the axial grooves  816  can extend into the proximal end  812  of the camming surface  806  to a depth equal to a depth of the retention depression  814 . 
     In some embodiments, the cold plate  116 , and specifically the distal end  802  of the distal protrusion  800  can be directly applied to a patient&#39;s skin to provide a cooling and/or freeze treatments. In some embodiments, one or several treatment tips  119 , also referred to herein as treatment caps  119  can be coupled to the cold plate  116  and directly applied to the patient&#39;s skin to provide a treatment that can include, for example, a dermabrasion treatment, a cooling treatment, and/or freeze treatment. With reference now to  FIG. 10 , a perspective view of one embodiment of a smooth tip  120  is shown. The smooth tip  120  can include an exterior housing  1000 , a contact surface  1002 , and a base  1004 . The contact surface  1002  can comprise a variety of shapes and sizes. In some embodiments, the contact surface  1002  can comprise a circular surface that can comprise a diameter of, for example, between 5 mm and 40 mm, between 10 mm and 30 mm, or any other or intermediate diameter. In some embodiments, the contact surface  1002  can comprise a square or rectangular surface that can comprise a length and/or width between 5 mm and 40 mm, between 10 mm and 30 mm, or any other or intermediate sizes. 
     In some embodiments, the contact surface  1002  of the smooth tip  120  can be smooth. In some embodiments, the smooth tip  120  can have a roughness Rz of between 5 and 50 microns, between 10 and 40 microns, between 20 and 30 microns, approximately 25 microns +/−10 microns, approximately 25 microns +/−5 microns, or any other or intermediate value. As seen in  FIG. 11 , a side view of the smooth tip  120 , the contact surface  1002  can, in some embodiments, be curved. The exterior housing  1000  of the smooth tip  120  can define a recess  1006  extending around housing  1000 . 
     With reference now to  FIG. 12 , a section view of the smooth tip  120  is shown. As seen in  FIG. 12 , the housing  1000  can define an opening  1200  in the base  1004  of the housing  1000 , which opening can extend into a receptacle  1202  defined by the housing  1000 . The receptacle  1202  can be configured to receive the cold plate  116 . The receptacle  1202  can be defined by mating surfaces  1204  having wholly or partially the same shapes as portions of the cold plate  116 , and specifically of the distal protrusion  800  and the camming surface  806 . These mating surfaces  1204  can be configured to mate with and/or directly or indirectly contact with the cold plate  116 , and specifically with the distal protrusion  800  and/or the camming surface  806  to facilitate heat transfer from the smooth tip  120  to the cold plate  116 . In some embodiments, the smooth tip  120  can be thermally coupled to the cold plate  116  via these mating surfaces  1204 , and in some embodiments via a thermally conductive coupling fluid applied to the mating surfaces  1204  and/or to the cold plate  116 . 
     The smooth tip  120 , and specifically, the housing  1000  can comprise a retention feature  1206 , which can, in some embodiments, comprise an compliant member coupled to the housing  1000 . As specifically depicted in  FIG. 12 , the retention feature  1206  comprises a compliant member in the form of an O-ring  1208 , such as a rubber O-ring, that is retained in a recess  1210  defined by the housing  1000 . In some embodiments, this compliant member, and specifically O-ring  1208 , can be configured to be received and retained within the retention depression  814  of the cold plate  116  when the smooth tip  120  is coupled to the cold plate  116 . As will be discussed below, all of tips  119  can include similar retention features to allow those tips  119  to be coupled to the cold plate  116 . 
     In some embodiments, for example, when the smooth tip  120  is coupled to the cold plate  116 , the compliant member, and specifically the O-ring  1208 , can engage with the camming surface  806 , which can deform, and specifically can expand the diameter of the compliant member, and specifically the O-ring  1208 . This deformation of the compliant member can occur until the cold plate  116  has been sufficiently inserted into the receptacle  1202  of the housing  1000  of the smooth  120  such that the compliant member, more specifically the O-ring  1208 , is received within the retention depression  814 . Due to the smaller diameter of the retention depression  814 , the compliant member can return to its undeformed shape or to a less deformed shape. This can include the decreasing of the diameter of the O-ring. This return to an undeformed or to a less deformed shape retains the smooth tip  120  on the cold plate  116 . The smooth tip  120  can be decoupled from the cold plate  116  by applying sufficient force to extract the compliant member from the retention depression  814 . 
     In some embodiments, axial grooves  816  can facilitate the coupling and decoupling of the smooth tip from the cold plate. Specifically, these axial grooves  816  prevent the sealing of the compliant member, and specifically the O-ring  1208  around the cold plate  116 . Preventing this sealing likewise prevents the creation of a vacuum when the smooth tip  120  is removed from the cold plate  116  or the creation of pressurized gas or fluid when the smooth tip  120  is coupled to the cold plate  116 . 
     In some embodiments, absence of the axial grooves  816  can result in the entrapment of air between the cold plate and a treatment tip  119 . The entrapped air can provide several disadvantages. Specifically, in embodiments in which the treatment tip  119  is thermally connected to the cold plate to enable the providing of cooling and/or freeze treatment, this entrapped air can decrease the thermal coupling between the cold plate and the treatment tip. Further, this entrapped air can decrease the stability of the connection of the treatment tip  119  to the cold plate. 
       FIGS. 13 through 19  shows views of an embodiment of a tip  119 , and specifically of a textured tip  122 . In some embodiments, the textured tip  122  can be sufficiently textured so as to abrade skin when the textured tip  122  is rubbed on the skin. 
     As seen in  FIG. 13 , a perspective view of the textured tip  122  can include an exterior housing  1300 , a contact surface  1302 , and a base  1304 . The contact surface  1302  can be flat, planar, non-planar, dimpled, concave, or convex. The contact surface  1002  can comprise a variety of shapes and sizes. In some embodiments, the contact surface  1002  can comprise a circular surface that can comprise a diameter of, for example, between 5 mm and 40 mm, between 10 mm and 30 mm, or any other or intermediate diameter. In some embodiments, the contact surface  1002  can comprise a square or rectangular surface that can comprise a length and/or width between 5 mm and 40 mm, between 10 mm and 30 mm, or any other or intermediate sizes. In some embodiments, the contact surface  1302  of the textured tip  122  can be textured. In some embodiments, the textured tip  122  can have a roughness Rz of between 50 and 270 microns, between 60 and 200 microns, between 70 and 150 microns, approximately 100 microns +/−20 microns, approximately 100 microns +/−10 microns approximately 100 microns +/−5 microns, approximately 80 microns +/−10 microns, approximately 80 microns +/−5 microns, approximately 75 microns +/−10 microns, approximately 75 microns +/−5 microns, or any other or intermediate value. As seen in  FIG. 14 , a side view of the textured tip  122 , the contact surface  1302  can, in some embodiments, be curved. The exterior housing  1302  of the textured tip  122  can define a plurality of recesses  1306  extending around housing  1000 . In some embodiments, the smooth tip  120  and the textured tip  122  can have a different number of recesses  1006 ,  1306  to enable easy visual or tactile differentiation between the smooth tip  120  and the textured tip  122 . 
     With reference now to  FIG. 15 , a section view of the textured tip  122  is shown. As seen in textured tip  122 , the housing  1300  can define an opening  1200  in the base  1304  of the housing  1300 , which opening can extend into a receptacle  1202  defined by the housing  1300 . The receptacle  1202  can be configured to receive the cold plate  116 . The receptacle  1202  can be defined by mating surfaces  1204  having wholly or partially the same shapes as portions of the cold plate  116 , and specifically of the distal protrusion  800  and the camming surface  806 . These mating surfaces  1204  can be configured to mate with and/or directly or indirectly contact with the cold plate  116 , and specifically with the distal protrusion  800  and/or the camming surface  806  to facilitate heat transfer from the smooth tip  120  to the cold plate  116 . In some embodiments, the smooth tip  120  can be thermally coupled to the cold plate  116  via these mating surfaces  1204 , and in some embodiments via a thermally conductive coupling fluid applied to the mating surfaces  1204  and/or to the cold plate  116 . 
     The textured tip  122 , and specifically, the housing  1300  can comprise a retention feature  1206 , which can, in some embodiments, comprise an compliant member coupled to the housing  1300 . As specifically depicted in  FIG. 15 , the retention feature  1206  comprises a compliant member in the form of an O-ring  1208 , such as a rubber O-ring, that is retained in a recess  1210  defined by the housing  1300 . In some embodiments, this compliant member, and specifically O-ring  1208 , can be configured to be received and retained within the retention depression  814  of the cold plate  116  when the textured tip  122  is coupled to the cold plate  116 . 
     In some embodiments, for example, when the textured tip  122  is coupled to the cold plate  116 , the compliant member, and specifically the O-ring  1208 , can engage with the camming surface  806 , which can deform, and specifically can expand the diameter of the compliant member, and specifically the O-ring  1208 . This deformation of the compliant member can occur until the cold plate  116  has been sufficiently inserted into the receptacle  1202  of the housing  1300  of the smooth  120  such that the compliant member, more specifically the O-ring  1208 , is received within the retention depression  814 . Due to the smaller diameter of the retention depression  814 , the compliant member can return to its undeformed shape or to a less deformed shape. This can include the decreasing of the diameter of the O-ring. This return to an undeformed or to a less deformed shape retains the textured tip  122  on the cold plate  116 . The textured tip  122  can be decoupled from the cold plate  116  by applying sufficient force to extract the compliant member from the retention depression  814 . 
     In some embodiments, axial grooves  816  can facilitate the coupling and decoupling of the smooth tip from the cold plate. Specifically, these axial grooves  816  prevent the sealing of the compliant member, and specifically the O-ring  1208  around the cold plate  116 . Preventing this sealing likewise prevents the creation of a vacuum when the textured tip  122  is removed from the cold plate  116  or the creation of pressurized gas or fluid when the textured tip  122  is coupled to the cold plate  116 . 
     With reference now to  FIG. 16 , a section view of one embodiment of a tip  199 , and specifically of a suspension assembly tip  1600 . The suspension assembly tip  1600  comprises a suspension tip  1602  and a suspension  1604 . The suspension  1604  is configured to engage with both the suspension tip  1602  and the cold plate  116 . 
     The suspension assembly tip  1600  provides several advantages, including, for example, selectively thermally isolating the suspension tip  1602  from the cold plate  116 . In some embodiments, for example, the suspension  1604  can comprise a thermal insulator which can thermally isolate the suspension tip  1602  from the cold plate  116 . Alternatively, in some embodiments, the suspension  1604  can comprise thermal conductor to thereby closely thermally couple the suspension tip  1602  to the cold plate  116 . In some embodiments, the suspension tip  1602  is thermally isolated from the cold plate  116  when the suspension tip  1602  maintains a surface temperature at or above 20° C., at or above 10° C., at or above between 10° C. and  20 ° C., or any other or intermediate temperature while a treatment is being provided. In some embodiments, the suspension tip  1602  is thermally isolated from the cold plate  116  when the suspension tip  1602  maintains a surface temperature at or above 20° C., at or above 10° C., at or above between 10° C. and 20° C., or any other temperature above the temperature of the cold plate  116  and/or above the temperature of the cold plate  116  and below the temperature of the patient&#39;s skin. In some embodiments, the suspension tip  1602  can be sufficiently thermally isolated so as to maintain a surface temperature at or above 20° C. when the cold plate  116  is at a temperature from between 20° C. to −30° C. In some embodiments, the suspension tip  1602  is closely thermally coupled to the cold plate  116  when the suspension tip does not maintain a surface temperature at or above 20° C. while a treatment is being provided. 
     In some embodiments, the suspension assembly tip  1600  can further more consistently and uniformly apply force to a treatment area. Specifically, as the suspension assembly tip  1600  is moved across the treatment area, the suspension  1604  can allow the suspension tip  1602  to move with respect to the cold plate  116  to thereby adjust to the topography of the treatment area. This results in move consistent contact between the suspension tip  1602  and the skin in the treatment area, and more consistent forces between the suspension tip  1602  and the skin in the treatment area. 
     The suspension tip  1602  can comprise exterior housing  1300 , a contact surface  1302 , and a base  1304 . The contact surface  1302  can be flat, planar, non-planar, dimpled, concave, or convex. The contact surface  1002  can comprise a variety of shapes and sizes. In some embodiments, the contact surface  1002  can comprise a circular surface that can comprise a diameter of, for example, between 5 mm and 40 mm, between 10 mm and 30 mm, or any other or intermediate diameter. In some embodiments, the contact surface  1002  can comprise a square or rectangular surface that can comprise a length and/or width between 5 mm and 40 mm, between 10 mm and 30 mm, or any other or intermediate sizes. In some embodiments, the contact surface  1302  can be smooth or can be textured. In some embodiments, the textured tip  122  can have a roughness Rz of between 50 and 270 microns, between 60 and 200 microns, between 70 and 150 microns, approximately 100 microns +/−20 microns, approximately 100 microns +/−10 microns approximately 100 microns +/−5 microns, approximately 80 microns +/−10 microns, approximately 80 microns +/−5 microns, approximately 75 microns +/−10 microns, approximately 75 microns +/−5 microns, or any other or intermediate value. 
     As seen in  FIG. 17 , the housing  1300  can define an opening  1200  in the base  1304  of the housing  1300 , which opening can extend into a receptacle  1202  defined by the housing  1300 , and specifically by an interior wall  1702  of the housing  1300 . The receptacle  1202 , which can be defined by, and/or formed in the interior wall  1702  of the housing  1300 , can be configured to hold and/or engage with the suspension  1604  and to receive the cold plate  116 . 
     In some embodiments, the receptacle  1202  can include a retention groove  1606  configured to engage with a portion of the suspension  1604  to couple the suspension  1604  to the suspension tip  1602 , and a suspension lip  1608 . Each of the suspension lip  1608  and the retention groove  1606 , as shown in  FIG. 17 , can be formed in and/or by the interior wall  1702  of the housing. In some embodiments, the suspension lip  1608  can be formed in the interior wall  1702  of the housing  1300  at a position relatively more proximate to the contact surface  1302  than to the base  1304  of the housing  1300 . In some embodiments, the suspension groove  1606  can be formed in the interior wall  1702  of the housing  1300  at a position relatively more proximate to the base  1304  of the housing than to the contact surface  1302  of the housing  1300 . 
     The suspension groove  1606  can be sized and shaped to receive and retain a tip coupling feature such as external connector  1820  of the suspension  1604 . In some embodiments, the suspension groove  1606  can be a size and/or shape to allow some movement of the tip coupling feature with respect to the suspension groove  1606 , and/or with respect to the suspension  1606 . When the suspension assembly tip  1600  is connected to the cold plate  116 , then the suspension groove  1606  can be sized and/or shaped to allow some movement of the suspension tip  1602  with respect to the cold plate  116 . In some embodiments, both the tip coupling feature and the suspension groove  1606  can be sized and/or shaped to allow the tip coupling features to move, for example, up to: 1 mm 2 mm, 3 mm, 4 mm, 5 mm, 6 mm, 7 mm, or any other or intermediate distance with respect to the suspension groove. In some embodiments this movement can be in the direction indicated by arrow  1620 . 
     The suspension lip  1608  can be configured to engage with one or several features of the suspension  1604  to thereby suspend the suspension tip  1602 . The suspension lip  1608  can extend around all or portions of the receptacle  1202 . In some embodiments, the suspension lip  1608  can circumferentially extend around an interior of the receptacle  1202  to form a continuous rim that can engage with one or several suspension members  1810 . The one or several suspension members  1810  can each comprise, for example, a flexible element extending from a central member  1804  of the suspension  1604 . In some embodiments, each of the suspension members  1810  can comprise a torsion bar configured to apply force to the suspension lip  1608  to bias the suspension tip  1602  towards a stable position. In some embodiments, the suspension  1604  drives the suspension tip  1602  to the stable position when no external force is applied to the suspension tip  1602 . 
     In some embodiments, the suspension lip  1608 , the suspension groove  1606 , and the suspension  1604  are sized and shapes such that when the suspension  1604  is received within the receptacle  1202  and the tip coupling features are received within the suspension groove  1606 , the suspension members  1810  are preloaded. In some embodiments, this preload can be manifest in a deflection of one or several of the suspension members  1810  when the suspension tip  1602  is in the stable position. In some embodiments, the suspension members  1810  can be preloaded such that a force of less than  6  ounces applied to the suspension tip  1602  does not result in any additional deflection of the suspension members  1810 . 
     A side view of the suspension  1604  is shown in  FIG. 18 . The suspension can comprise a variety of shapes and sizes and can be made from a variety of materials. In some embodiments, the entirety of the suspension  1604  can be made from a single material and/or type of material and in some embodiments, different parts of the suspension  1604  can be made from different materials. In some embodiments, the suspension can be made from a natural material or a synthetic material. In some embodiments, the suspension  1604  can be made from a polymer, an elastomer, or a metal. In some embodiments, the suspension  1604  can comprise a polymer such as polyamide. In some embodiments in which the suspension  1604  thermally isolates the suspension tip  1602  from the cold plate  116 , the suspension  1604  can be made from a polymer having a low thermal conductivity. In some embodiments in which the suspension  1604  closely thermally couples the suspension tip  1602  with the cold plate  116 , the suspension  1604  can be made from a metal or other material having a high thermal conductivity. 
     The suspension includes a top  1802  and a bottom  1803 . The top  1802  of the suspension  1604  comprises a central member  1804 . The central member  1804  can comprise a variety of shapes and sizes. In some embodiments, the central member  1804  can comprise a cylindrical member, which cylindrical member can comprise, for example, a circular cross-section. In some embodiments, and as depicted in  FIGS. 16 and 19 , the central member  1804  can be hollow and/or define a lumen extending through the central member  180 . 
     In some embodiments, the central member  1804  can define a central receptacle  1805 . In some embodiments, the central receptacle  1805  can be sized and/or shaped to receive a portion of the cold plate  116  when the suspension assembly tip  1600  is coupled to the cold plate  116 . Specifically, in some embodiments, the central receptacle  1805  can be configured to receive the distal protrusion  800  and prevent the distal protrusion  800 , and specifically the distal end  802  of the distal protrusion  800  from contact the suspension tip  1602 . 
     In some embodiments, the central member  1804 , and the suspension  1604  can have a central axis  1806  extending centrally through the suspension  1604  and through the top  1802  and the bottom  1803  of the suspension  1604 . 
     The suspension  1604  comprises a suspension member array  1808  that can comprise a plurality of suspension members  1810 . Each of the suspension members  1810  can comprise a variety of shapes and sizes and can be made from a variety of materials. In some embodiments, each of the suspension members  1810  can be resilient to allow each suspension member  1810  to elastically deform and then return to its original position. In some embodiments, and as seen in  FIG. 19 , each of the suspension members  1810  can comprise a cantilevered beam, having a proximal end  1902  connected to the central member  1804  and a distal end  1904  that engages with the suspension lip  1608 . In some embodiments, the cantilevered beam can comprise a rectangular cross-section. 
     Each of the suspension members  1810  in the suspension member array  1810  can deflect towards the top  1802  of the suspension  1604  and/or towards the bottom  1803  of the suspension  1604 . In some embodiments, each of the suspension members  1810  can deflect up to, for example, 1 mm, 2 mm, 3 mm, 4 mm, 5 mm, 6 mm, 7 mm, 8 mm, 9 mm, 10 mm, or up to any other or intermediate value towards the top  1802  of the suspension  1604  and/or towards the bottom  1803  of the suspension  1604 . In some embodiments, a suspension member  1810  on one side of the suspension member array  1808  can deflect towards the bottom  1803  and a suspension member  1810  on the opposite side of the suspension member array  1808  can deflect in an opposite direction towards the top  1802  of the suspension  1604 , or in the same direction but to a lesser extent, thereby providing a rocking motion to suspension tip  1602 . 
     The plurality of suspension members  1810  can be circumferentially distributed around the central member  1804  so as to be evenly distributed about the central axis  1806 . In some embodiments, the suspension members  1810  can be equidistantly arranged around the central axis  1806  and can extend from the central member  1804  in a spoke-like fashion. In some embodiments, some or all of the plurality of suspension members  1810  can be entirely within a common plane, and/or can extend in a direction perpendicular to the central axis  1806 . 
     The suspension  1604  can comprise any desired number of suspension members  1810  including, for example, 4, 5, 6, 7, 8, 9, 10, 12, 14, 16, 18, 20, 30, 40, 50, 100, or any other or intermediate number of suspension members  1810 . In some embodiments, the suspension  1604  can comprise, for example, more than 4 suspension members  1810 , more than 6 suspension members  1810 , more than 8 suspension members  1810 , more than 10 suspension members  1810 , more than 20 suspension members  1810 , more than 30 suspension members  1810 , more than 40 suspension members  1810 , more than 60 suspension members  1810 , more than 80 suspension members  1810 , more than 100 suspension members  1810 , or any other or intermediate number of suspension members  1810 . 
     The suspension  1604  can comprises a coupling member array  1812  comprising a plurality of coupling members  1814 . In some embodiments, each coupling member  1814  can be configured to connect the suspension  1604  to the cold plate  116  and to the suspension tip  1602 . The suspension  1604  can comprise any desired number of coupling members  1814  in the coupling member array  1812  including, for example, 4, 5, 6, 7, 8, 9, 10, 12, 14, 16, 18, 20, 30, 40, 50, 100, or any other or intermediate number of coupling members  1814 . In some embodiments, the suspension  1604  can comprise, for example, more than 4 coupling members  1814 , more than 6 coupling members  1814 , more than 8 coupling members  1814 , more than 10 coupling members  1814 , more than 20 coupling members  1814 , more than 30 coupling members  1814 , more than 40 coupling members  1814 , more than 60 coupling members  1814 , more than 80 coupling members  1814 , more than 100 coupling members  1814 , or any other or intermediate number of coupling members  1814 . In some embodiments, the coupling member array  1812  can include the same number of coupling members  1814  as the number of suspension members  1810  in the suspension member array  1808 . In some embodiments, the coupling member array  1812  can include a different number of coupling members  1814  than the number of suspension members  1810  in the suspension member array  1808 . 
     As seen in  FIG. 19 , each of the coupling members  1814  can comprise a proximal end  1906  connected to the central member  1804 , and can extend downward and radially away to a distal end  1908 . In some embodiments, the plurality of coupling members  1814  can be circumferentially distributed around the central member  1804  so as to be evenly distributed about the central axis  1806 . In some embodiments, the coupling members  1814  can be equidistantly arranged around the central axis  1806  and can extend from the central member  1804  in a spoke-like fashion. In some embodiments, due to the downward and radially outward extension of the coupling members  1814 , the coupling member array  1812  can be conical, and specifically can have a shape of a truncated cone. 
     Each of the coupling members  1814  can include a coupling arm  1816  and a coupling head  1818 . As seen in  FIG. 18 , the coupling arm  1816  can connect at its proximal end to the central member  1804  and at its distal end to the coupling head  1818 . The coupling head  1818  can include an external connector  1820  configured to connect with the suspension tip  1602 , and specifically to the suspension groove  1606  of the suspension tip  1602 . The coupling head  1818  can further include an internal connector  1822  configured to connect with the cold plate  116 , and specifically with the retention depression  814  of the cold plate  116 . 
     In some embodiments, the external connector  1820  can comprise a deflection arm  1824  and an engagement head  1826 . The engagement head  1826  of the external connector  1820  can be configured to engage with the suspension groove  1606  of the suspension tip  1602 , and specifically to be received within the suspension groove  1606  of the suspension tip  1602 . The deflection arm  1824  can be configured to deflect so as to facilitate the engagement of the engagement head  1826  with the suspension groove  1606  of the suspension tip  1602 . 
     In some embodiments, the internal connector  1822  can comprise a deflection arm  1828  and an engagement head  1830 . The engagement head  1830  of the internal connector  1822  can be configured to engage with the cold plate  116 , and specifically to be received within the retention depression  814  of the cold plate  116 . The deflection arm  1828  can be configured to deflect so as to facilitate the engagement of the engagement head  1830  with the cold plate  116 , and specifically with the retention depression  814  of the cold plate  116 . 
     With reference now to  FIG. 20 , a schematic illustration of one embodiment of the chiller  211  is shown. The chiller  211  can include a coolant circulation system  2000  that can be coupled to a refrigeration unit  212  via a heat exchanger  2002 . The coolant circulation system  2000  can be configured to circulate coolant through the coolant circulation system  2000 , including through the handpiece  112 . In some embodiments, this coolant can be a heat sink to which the cooler  230  of the handpiece  112  can transfer heat from the cold plate  116 . 
     In some embodiments, as depicted in  FIG. 20 , the refrigeration unit  212  can be configured to cool coolant in the coolant circulation system  2000 , and the heater  206  can be configured to heat coolant in the coolant circulation system  2000 . In some embodiments, the combination of the heater  206  and the refrigeration unit  212  can allow the cooling of the coolant to within a desired temperature range, and specifically can allow cooling of the coolant to a desired temperature range while decreasing the need to vary the cooling output of the refrigeration unit  212 . In some embodiments, for example, the refrigeration unit  212  may have a longer lifetime, if the output of the refrigeration unit  212  remains relatively constant. To enable control of coolant temperature while maintaining relatively constant refrigeration unit  212  output, the heater  206  can heat the coolant. Thus, management of temperature of the coolant can be performed in large part by heater  206  based on temperature data gathered from the temperature sensor  208 . 
     The circulation system  2000  can include a coolant reservoir  2004  which can contain coolant. In some embodiments, the level of coolant in the coolant reservoir  2004  can be measured by the liquid sensor  218 . In the event that coolant levels measured by the liquid sensor  218  drop below a predetermined level, an error message or warning can be provided to the user via, for example, a graphical user interface (GUI) on the display  104  and/or via the speaker  238 . 
     In some embodiments, the coolant pump  220  can circulate coolant through the circulation system  2000 . In some embodiments, this pump can provide a further control cooling of the coolant provided to the handpiece  112 . Specifically, if more cooling is desired, the rate with which the coolant is circulated can be increased and/or the temperature of the coolant can be decreased. Likewise, if less cooling is desired, the rate with which the coolant is circulated can be decreased and/or the temperature of the coolant can be increased. 
       FIG. 21  is a flowchart illustrating one embodiment of a process  2100  for delivering a skin cooling treatment to a patient, and more specifically to an area of skin of a patient. The process  2100  can be performed by the cooling treatment system  100 . 
     The process  2100  begins at block  2102 , wherein a self-check is performed. In some embodiments, the self-check can be periodically performed, or can be performed when, for example, the cooling treatment system  100  is turned on, woken up, or the like. In some embodiments, the self-check can check to determine if: coolant levels are satisfactory; if components of the cooling treatment system  100  are functional; if the handpiece  112  is present; or the like. The self-check can be performed by the controller  110 . In some embodiments, the self-check can include determining: communication connection with components of the cooling treatment system  100  such as with the chiller  211 ; the ability to control powering of the cooler  230 ; presence of the handpiece  112  including, gathering the type and/or serial number of the handpiece  112 ; operation of the handpiece  112  and/or components of the handpiece including, for example, the motor  232 , the temperature sensor(s)  236 , the speaker  238  and/or any other indicators such as one or several LEDs, or the like. 
     At block  2104 , any errors triggered by the self-check can be indicated to the user. This can include controlling the GUI on the display  104  to provide a visual indication and/or visual identification of any errors to the user, and/or providing an audible indication of any errors to the user via, of example, the speaker  238 . If no errors are detected, the GUI can be controlled to display the image of  FIG. 23 , which indicates readiness to receive an artifact  107 . 
     At block  2106 , an artifact  107 , such as a card is received. In some embodiments, the artifact can be received by a physical feature associated with the reader  106 . In some embodiments, for example, the reader can include a physical feature, such as a slot, configured to receive the artifact  107 . In such an embodiment, the artifact  107  can be received by this feature, and specifically can be received within the slot. In some embodiments, and instead of a physical artifact, a non-physical artifact can received and/or read. In some embodiments, this can include accessing information contained in a digital artifact. 
     After the artifact  107  has been received, the artifact  107  can be read as indicated in block  2108 . In some embodiments, this can include reading data from the artifact  107 . This can include, for example, powering features of the artifact  107 , such as, for example, a microprocessor of the artifact  107 , querying the artifact  107  for information, and/or receiving data from the artifact  107 . In some embodiment, reading data from the artifact can include determining a value of the count of available treatment cycles associated with the artifact. If it is determined that the artifact has at least one treatment cycle available, then the process  2100  can proceed to block  2110 . Alternatively, if it is determined the artifact has no available treatment cycles available, then the lack of available treatment cycles can be indicated to the user and the process  2100  can terminate. This reading and determining can be performed by the reader  106 . 
     Based on information read from the artifact  107 , at block  2110 , which artifact  107  has at least one remaining treatment cycle in its count of available treatment cycles, a type of machine for the cooling treatment is identified. In some embodiments, this can include determining if the data retrieved from artifact identifies a type of cooling treatment system  100  for performing the treatment. As previously discussed, some embodiments of the cooling treatment system  100  may provide different cooling/temperature control of the cold plate  116 , and thus certain treatments may be provided via different embodiments of the cooling treatment system  100 . If the data identifies a machine for providing the cooling treatment, then it is determined if the cooling treatment system  100  having read the artifact  107  in block  2108  matches the machine type specified in the read data. If it is determined that the machine types do not match, then the process  2100  can terminate, and an indication of the termination and the reason for termination can be provided to the user. 
     If it is determined that the machine types match, then the process  2100  can proceed. At block  2112 , treatment instructions can be identified in the data read from the artifact in block  2108 . In some embodiments, this can include identifying treatment instructions stored on the artifact  107 . These treatment instructions can include, for example, instructions for a technical treatment, a freeze treatment, and a restore treatment. In some embodiments in which the treatment comprises a freeze treatment or a restore treatment, the treatment instructions can include at least one temperature profile that can identify a plurality of temperatures and an associated time for maintaining each of the plurality of temperatures. 
     One embodiment of a treatment profile  2200  is shown in  FIG. 22 . As seen in  FIG. 22 , the treatment profile  2200  identifies a plurality of temperatures and a time associated with each of the temperatures. For example, the treatment profile  2200  non-exclusively indicates a temperature of +20° C. for a duration of 0 seconds, followed by a temperature of −4° C. for a duration of 85 seconds for a freeze treatment, followed by a temperature of +7° C. for a duration of 15 seconds, followed by a temperature of +15° C. for a duration of 1 second, followed by a temperature of +1° C. for a duration of 195 seconds, followed by a temperature of +7° C. for a duration of 5 seconds, followed by a temperature of +20° C. for a duration of 600 seconds (a dwell time), followed by a temperature of +15° C. for a duration of 1 second, followed by a temperature of +1° C. for a duration of 180 seconds, followed by a temperature of +7° C. for a duration of 20 seconds, followed by a temperature of +15° C. for a duration of 1 second, followed by a temperature of +1° C. for a duration of 165 seconds, followed by a temperature of +7° C. for a duration of 35 seconds, followed by a temperature of +15° C. for a duration of 1 second, followed by a temperature of +20° C. for a duration of 600 seconds, followed by a temperature of +15° C. for a duration of 1 second, followed by a temperature of +1° C. for a duration of 150 seconds, followed by a temperature of +7° C. for a duration of 50 seconds, followed by a temperature of +20° C. for a duration of 1 second, followed by a temperature of +1° C. for a duration of 135 seconds, and a final temperature of 7° C. for a duration of 15 seconds. 
     At block  2114 , a GUI corresponding to the identified treatment is launched. In some embodiments, for example, this can include launching a GUI for a technical treatment when the identified treatment is a technical treatment, launching a GUI for a freeze treatment when the identified treatment is a freeze treatment, and launching a GUI for a restore treatment when the identified treatment is a restore treatment.  FIGS. 24 through 28  depict one embodiment of a launched GUI that is associated with a restore treatment, and  FIGS. 29 through 28  depict one embodiment of a launched GUI that is associated with a freeze treatment. In some embodiments, the GUI can display information relating to the identified treatment. For example, the GUI as represented in  FIG. 29  identifies two treatment profiles with different cooling rates and for providing the treatment. Specifically,  FIG. 29  indicates that a Cooling Factor, which is a non-dimensional indicator of cooling rate, of 3.8 should be applied for a duration of 16 seconds and that a Cooling Factor of 4 should also be applied for a duration of 16 seconds. 
     At block  2116 , the treatment instructions are retrieved from the artifact  107 . In some embodiments, this step can be performed as a part of the reading of the artifact  107  performed in block  2108 . The retrieving of the treatment from the artifact  107  can include the downloading of information identifying the treatment from the card. 
     At block  2117 , instructions are received from the user to provide a treatment and/or an indication is received from the user to provide a treatment. This indicator and/or instructions can be received via the user providing an input via, for example, the display  104 , via the controls  240  on the handpiece  112 , and/or via a detection of a change in skin contact status by, for example, the cap touch  234 , a temperature sensor, a pressure sensor, or the like. In some embodiments, and upon receipt of the indication from the user to provide the treatment, the value of the artifact&#39;s count of available treatment cycles is decremented. In some embodiments, and upon starting a treatment, the value of the artifact&#39;s count of available treatment cycles is decremented. 
     At block  2118 , a next step in the treatment is identified. In some embodiments, if the treatment has not yet been started, this can be the first step in the treatment. This next step can be identified from the downloaded treatment. The next step can be, in some embodiments, a freeze or freezing step, a cooling step, and/or a warming or a rewarming step. After the next step in the treatment has been identified, the GUI is controlled to guide the user through performing user actions of the next step as indicated in block  2120 . In some embodiments, the step of block  2120  can include multiple sub-steps that can be performed before, simultaneous with, and/or subsequent to one or several others of the steps shown in blocks  2122 . For example, the step of block  2120  can include directing the user to cool some of the patient&#39;s skin, which can be performed after block  2128  and/or block  2130 , or in other words, after the cold plate  116  has achieve a desired temperature and after an indicator of beginning of treatment identified in the next step is received. 
       FIGS. 25 through 28  show actions to be taken by user as part of the identified treatment step of a restore treatment. This includes, as shown in  FIG. 25 , the placement of a tip  119  on the cold plate  116 . This can include indication of which tip  119  to place on the cold plate  116 . Thus, the GUI in  FIG. 25  indicates that a smooth tip  120  should be connected to the cold plate  116 .  FIG. 26  indicates that button  700  of the handpiece  112  should be pressed. This can be pressed upon completion of other user actions associated with the identified step. 
       FIGS. 27 and 28  are depictions of a GUI showing action to be performed by the user with the handpiece  112 .  FIG. 27  shows where and how the user should apply the treatment tip  119  to perform the treatment.  FIG. 27  further includes a countdown timer  2700  which can show the amount of time for providing the action and/or treatment indicated on the GUI, a termination icon  2702  that can be manipulated to terminate the treatment, and an advance icon  2704  that can be manipulated to advance to a next action in the treatment step. In some embodiments, the treatment can further be terminated via a user input received via the handpiece  112 , and specifically via the button  700  of the handpiece  112  and/or via a detection of a change in skin contact status by, for example, the cap touch  234 , a temperature sensor, a pressure sensor, or the like. In some embodiments, and as discussed with respect to block  2130 , the countdown timer can begin its countdown upon detection of a treatment trigger and/or upon receipt of an indication of the beginning of the performing of the associated treatment step. In some embodiments, this can include receipt of a signal indicating initiation of a treatment, and/or detection of an event indicating initiation of a treatment. This can include, for example upon detection of the pressing of the button  700  on the handpiece  112  by the user, by the capacitive touch sensor  234  detecting contact between the cold plate and/or treatment tip  119  and the patient&#39;s skin, detecting a temperature change of the cold plate and/or of the treatment tip indicative of contact with the patient&#39;s skin. 
       FIG. 28  is a depiction of the GUI directing a user for providing a dwell time. As seen in  FIG. 28 , the GUI includes a countdown timer  2700  which shows the amount of time remaining in the dwell time. In some embodiments, and as discussed with respect to block  2130 , the countdown timer can begin its countdown upon detection of a treatment trigger and/or upon receipt of an indication of the beginning of the performing of the associated treatment step. This, the countdown timer can begin its countdown for example upon detection of the pressing of the button  700  on the handpiece  112  by the user and/or via detection of a change in skin contact status by, for example, the cap touch  234 , a temperature sensor, a pressure sensor, or the like. 
       FIGS. 30 through 32  are depictions of a GUI showing actions to be performed by the user with the handpiece  112  as part of a freeze treatment.  FIG. 30  indicates that the user should press the button  700 . This pressing of the button can, in some embodiments, start the cooling of the cold plate  116  to a desired cold plate temperature.  FIG. 31  indicates that the user should apply the cold plate to the patient&#39;s skin.  FIG. 31  further includes a countdown timer  2700 .  FIG. 32  shows the cold plate  116  applied to the patient&#39;s skin, and the countdown timer  2700  is indicated as counting down the time until completion of the treatment step. 
     In some embodiments, guiding the user through performing user actions of the next step can include, for example, identifying at least one topical and directing the application of the topical to the area of skin of the patient optionally using the handpiece tip, or textured tip or smooth tip applied to the handpiece to distribute the topical. In some embodiments, this can further include directing the user to cool the area of skin of the patient via the handpiece  112 . 
     In some embodiments, directing the user to cool the area of skin of the patient via the handpiece  112  can include directing the user to contact the area of skin of the patient with the cold plate  116  and directing the user to depress a button  700  to indicate initiation of delivery of treatment of the identified next step. In some embodiments, directing the user to cool the area of skin of the patient via the handpiece  112  can include directing the user to connect a treatment tip  119  to the cold plate  116  of the handpiece  112 , contact the area of skin of the patient with the treatment tip  119  connected to the cold plate  116 , and depress a button  700  to indicate initiation of delivery of treatment of the identified next step. This treatment tip  119  can, in some embodiments, be one of the smooth tip  120  and the textured tip  122 . In some embodiments, the GUI can be controlled to track the duration of a treatment step via, for example, a countdown timer. In some embodiments, a countdown timer can indicate a duration of remaining time that a handpiece  112  should be used to cool the patient&#39;s skin or a duration of remaining dwell time in which a topical should be allowed to sit, without and handpiece  112  interaction, on the patient&#39;s skin. 
     In some embodiments, controlling the GUI to guide the user through performing user actions of the next step can include, for example, directing the user to perform a cleanse step, also referred to herein as a purify step. In some embodiments, when directing the user to perform user actions of the cleanse step, the GUI can be controlled to direct the user to: massage cleanser into the patient&#39;s skin and/or into the patient&#39;s face and to remove the cleanser with gauze and/or a towel that can be, for example, water saturated or wet. 
     In some embodiments, controlling the GUI to guide the user through performing user actions of the next step can include, for example, directing the user to perform a freeze step, also referred to herein as focused cooling. In some embodiments, freeze step can include cooling the cold plate  116  to one or several temperatures at or below freezing. This can include, for example, temperatures from, for example, −30° C. to approximately 10° C., from, for example, −10° C. to approximately 10° C., or the like. In some embodiments, the user can be directed to hold the cold plate  116  on the portion of skin being treated for a desired amount of time including, for example, less than one minute, between 1 and 5 minutes, between 1 and 10 minutes, between 1 and 20 minutes, or the like. In some embodiments, when directing the user to perform user actions of the freeze step, the GUI can be controlled to direct the user to: assess a spot, insert a freeze card, select a temperature profile, apply a few drops of gel such as HYDRO GEL directly onto the treatment area, spread the gel with a finger, push the button  700  to initiate pre-cool, place the cold plate  116  on the treatment area upon completion of pre-cool, hold the cold plate  116  on the treatment area until the treatment is complete, clean the treatment area, and clean the cold plate  116 . 
     In some embodiments, controlling the GUI to guide the user through performing user actions of the next step can include directing the user to perform a peel step, also referred to herein as a loosen step. In some embodiments, peel step can include cooling the cold plate  116  to desired temperature, which can be, for example, between −4° C. to approximately 4° C., from, for example, −2° C. to approximately 2° C., approximately 1° C., or the like. In some embodiments, the user can be directed to apply cooling with the handpiece  112  on the portion of skin being treated for a desired amount of time including, for example, between 60 and 300 seconds, between 100 and 240 seconds, between 150 and 220 seconds, approximately 195 seconds, or the like. In some embodiments, the peel step can include directing the user to allow for a dwell time, which can be a time during which a topical is allowed to soak into the patient&#39;s skin and during which the handpiece  112  is NOT applied to the patient&#39;s skin. This dwell time can be, for example, between 120 and 1200 seconds, between 240 and 1000 seconds, between 400 and 800 seconds, approximately 600 seconds, or the like. The peel step can be performed with the smooth tip  120 . In some embodiments, when directing the user to perform user actions of the peel step, the GUI can be controlled to direct the user to, for example, directing the user to: insert a Rejuvenation Card, a tip  119  such as a smooth tip  120  to the cold plate  116 , apply a small amount of a topical such as a PEEL directly on the area of skin to be treated such as on the forehead and/or cheeks and/or chin, push the button  700  on the handpiece  112  to start, use handpiece  112  to spread the topical on the skin, leave the topical on the skin for a predetermined period of time such as for ten minutes, remove the topical from the skin with a wet towel or gauze, and clean the tip  119 . 
     In some embodiments, controlling the GUI to guide the user through performing user actions of the next step can include, for example, directing the user to perform a polish step, also referred to herein as a remove step. In some embodiments, polish step can include cooling the cold plate  116  to desired temperature, which can be, for example, between −4° C. to approximately 4° C., from, for example, −2° C. to approximately 2° C., approximately 1° C., or the like. In some embodiments, the user can be directed to apply cooling with the handpiece  112  on the portion of skin being treated for a desired amount of time including, for example, between 60 and 300 seconds, between 100 and 240 seconds, between 150 and 220 seconds, approximately 180 seconds, or the like. In some embodiments, the polish step can be performed with the texture tip  122 . In some embodiments, when directing the user to perform user actions of the polish step, the GUI can be controlled to direct the user to: attach a tip  119  such as the textured tip  122  to the cold plate  116 , applying a topical such as MIST on the area of skin to be treated such as on the forehead and/or cheeks and/or chin, etc., push the button  700  on handpiece  112  to start the treatment, for each section of skin, hold the skin taut and use long strokes while not going over the same area more than twice, spray additional topical onto the skin as needed throughout the cycle, cleaning the treated skin with a wet gauze or towel after completion of the cycle, spraying additional topical on the skin, and removing the tip  119  from the cold plate  116 . 
     In some embodiments, controlling the GUI to guide the user through performing user actions of the next step can include, for example, directing the user to perform a restore step, also referred to herein as a calm step. In some embodiments, the calm step can include cooling the cold plate  116  to desired temperature, which can be, for example, between −4° C. to approximately 4° C., from, for example, −2° C. to approximately 2° C., approximately 1° C., or the like. In some embodiments, the user can be directed to apply cooling with the handpiece  112  on the portion of skin being treated for a desired amount of time including, for example, between 60 and 300 seconds, between 100 and 240 seconds, between 150 and 200 seconds, approximately 165 seconds, or the like. In some embodiments, the calm step can include directing the user to allow for a dwell time, which can be a time during which a topical is allowed to soak into the patient&#39;s skin and during which the handpiece  112  is NOT applied to the patient&#39;s skin. This dwell time can be, for example, between 120 and 1200 seconds, between 240 and 1000 seconds, between 400 and 800 seconds, approximately 600 seconds, or the like. In some embodiments, the calm step can be performed with the smooth tip  120 . In some embodiments, when directing the user to perform user actions of the calm step, the GUI can be controlled to direct the user to: attach a tip  119  such as the first tip  120  to the cold plate  116 , apply topical such as MASK onto the skin to be treated such as on the forehead and/or cheeks and/or and chin, push the button  700  on the handpiece  112  to start, massaging the topical into the skin with the handpiece  112 , spraying additional topical onto the skin upon completion of the massaging, letting the topical sit on the skin for a period of time such as ten minutes, removing the topical from the skin with a wet towel or gauze, and cleaning the tip  119 . 
     In some embodiments, controlling the GUI to guide the user through performing user actions of the next step can include, for example, directing the user to perform a refresh step, also referred to herein as a defend step. In some embodiments, refresh step can include cooling the cold plate  116  to desired temperature, which can be, for example, between −4° C. to approximately 4° C., from, for example, −2° C. to approximately 2° C., approximately 1° C., or the like. In some embodiments, the user can be directed to apply cooling with the handpiece  112  on the portion of skin being treated for a desired amount of time including, for example, between 60 and 300 seconds, between 100 and 240 seconds, between 130 and 180 seconds, approximately 150 seconds, or the like. In some embodiments, the defend step can be performed with the smooth tip  120 . In some embodiments, when directing the user to perform user actions of the defend step, the GUI can be controlled to direct the user to: apply a topical such as SERUM directly on the skin to be treated such as the forehead and/or cheeks and/or chin, push the button  700  on the handpiece  112  to start, massage the topical into the skin with the handpiece  112  having a tip  119  such as the smooth tip  120 , and leave the topical on the skin after massaging and while cleaning the tip  119 . 
     In some embodiments, controlling the GUI to guide the user through performing user actions of the next step can include, for example, directing the user to perform a glow step, also referred to herein as a protect step. In some embodiments, glow step can include cooling the cold plate  116  to desired temperature, which can be, for example, between −4° C. to approximately 4° C., from, for example, −2° C. to approximately 2° C., approximately 1° C., or the like. In some embodiments, the user can be directed to apply cooling with the handpiece  112  on the portion of skin being treated for a desired amount of time including, for example, between 60 and 300 seconds, between 100 and 240 seconds, between 120 and 150 seconds, approximately 135 seconds, or the like. In some embodiments, the glow step can be performed with the smooth tip  120 . In some embodiments, when directing the user to perform user actions of the glow step, the GUI can be controlled to direct the user to: apply a topical such as MOISTURIZER on the skin to be treated such as the forehead and/or cheeks and/or chin, push the button  700  on the handpiece  112  to start, massage the topical into the skin with the handpiece  112  containing a tip such as the smooth tip  120 , massage any remaining topical into the skin with fingers, and remove and dispose of the tip  119 . 
     At step  2122  any set temperature associated with the next step is identified. Thus, if the next step involves a temperature-related treatment such as, for example, a cooling and/or a freezing treatment, the temperature associated with the identified next step of that treatment is identified. This temperature can be identified from the temperature profile. 
     At optional step  2123 , one or several topicals  132  can be applied to the skin to be treated. This can include removing one or several topicals  132  from case  130 , and then applying these one or several topicals  132  to the skin to be treated. The step can be performed by the user of the cooling treatment system  100 . 
     After the set temperature for the identified step is identified, a temperature of the cold plate can be set to that identified set temperature. In embodiments in which the identified step of block  2118  corresponds to a first temperature identified in the temperature profile, the temperature of the cold plate can be set to that first temperature identified in the freeze profile. In some embodiments, the temperature of the cold plate can be set via the steps of blocks  2124  and  2126 . At block  2124 , the chiller  211  is controlled to cool coolant in the chiller  211  to within a target range. In some embodiments, this can include the controlling of the refrigeration unit  212  and/or the heat load  206  to adjust the temperature of the coolant such that the temperature of the coolant is within the desired range. 
     In some embodiments, controlling the chiller  211  further includes controlling the pump  220  to control the circulation of coolant through the chiller  211  and through the handpiece  112 . In some embodiments, the control of the pump  220  can result in the circulating of the coolant through the handpiece  112 . 
     At block  2126 , the cooler  230  is controlled to cool the cold plate  116  to a desired cold plate temperature. In some embodiments, the cooler  230 , which can comprise a thermoelectric cooler, can cool the cold plate  116  by transferring heat energy from the cold plate  116  to the coolant circulating through handpiece  112 . In some embodiments, this heat transfer and thus the temperature of the cold plate  116  can be regulated according to information received from temperature sensor(s)  236 , which temperature sensor(s)  236  can, in some embodiments, sense a temperature of the cold plate  116 . 
     At block  2128 , an indication of treatment readiness is provided once the cold plate  116  has achieved the desired cold plate temperature. In some embodiments, this can be indicated by the display  104 , and specifically via the GUI visible on the display  104 . 
     At block  2130 , treatment tracking begins upon detection of an input indicating and/or triggering start of treatment. In some embodiments, this indication and/or trigger of the start of treatment can include the pressing of the button  700  on the handset  112 , the detecting of the pressing of the button  700  on the handset, receipt of an input via, the display  104 , via the controls  240  on the handpiece  112 , and/or via a detection of a change in skin contact status by, for example, the cap touch  234 , a temperature sensor, a pressure sensor, or the like. In some embodiments, treatment tracking can include the beginning of a timer, also referred to herein as a countdown timer, indicating a desired amount of time for performing the identified next step. In some embodiments treatment tracking can include controlling the GUI to display a countdown timer upon receipt of the indication of initiation of delivery of the treatment as in block  2128 , such as is shown in  FIG. 32  with timer  2700 . 
     Once the treatment step is completed as determined by the passing of the desired amount of time associated with the step identified in block  2118 , an indication of the completion of the step is provided to the user. In some embodiments, this indication can comprise a visual indication provided by the GUI and/or one or several LEDs, and in some embodiments, this indication can comprise a tactile and/or audible indication such as via the generation of vibration in the handpiece  112  with the motor  232  and/or via generation of a sound with the speaker  238 . 
     At block  2134 , the process  2100  determines if there are any remaining treatment steps. If there are remaining treatment steps, the process  2100  returns to block  2118  and proceeds as outlined above. If there are no remaining treatment steps, then the process  2100  proceeds to block  2136 , wherein treatment completion is signaled. This treatment completion can be signaled via one or more the GUI, one or more LEDs, the motor  232 , and the speaker  238 . 
     In some embodiments, process  2100  can be terminated upon receipt of a termination request as indicated in block  2140 . This termination request can be received, for example, from the user and/or can be generated by the cooling treatment system  100 . In some embodiments, for example, the termination request can be generated by the controller  110  and/or the handpiece controller  114  when a sensed temperature is outside of an acceptable range and/or falls above or below a temperature threshold value or a difference in temperature as measured by two or more sensors exceeds a limit. In some embodiments, this temperature can be a temperature of the cold plate  116 , a temperature of the chiller  211  of component of the chiller  211 , and/or a temperature of the cooler  230 . In some embodiments, for example, a termination request can be generated if the cold plate  116  is too cold or too hot. In some embodiments, the termination request can be generated in response to an indication from the cap touch  234  that the cold plate  116  has been removed from the patient&#39;s skin and/or is no longer in contact with the patient&#39;s skin. 
     After the termination request has been received and/or generated, the treatment is cancelled at block  2142 . In some embodiments, cancelling the treatment can comprise controlling the chiller  211  and/or cooler  230  to discontinue cooling and/or heating of the cold plate  116 . In embodiment in which the cold plate  116  is being cooled upon receipt of the termination request, cancelling the treatment can comprise controlling the chiller  211  and/or cooler  230  to rewarm the cold plate  116 . 
     Performing of the process  2100  can improve one or several attributes of the patient&#39;s skin. With reference now to  FIG. 33  a graph  3300  depicting measured improvements of a patient&#39;s skin subsequent to treatment according to the process  2100  is shown. As seen in the graph  3300 , multiple of the attributes of the patient&#39;s skin can improve subsequent to a treatment according to the process  2100 . These can include, for example, the appearance of fine lines and/or wrinkles, the skin&#39;s clarity and/or brightness, the skins tactile and/or visual roughness, evenness of the skins tone including redness and/or hyperpigmentation, and/or the skin&#39;s overall appearance. 
     With reference now to  FIG. 34 , before and after photos  3402 ,  3404  are shown depicting the improvement to a patient&#39;s skin subsequent to receiving the treatment of process  2100 . Improvements to the patient&#39;s skin are visible in comparing a first photo  3402  taken before the treatment to a second photo  3404  taken approximately eight weeks after receiving the treatment of process  2100 . 
     This description should not be interpreted as implying any particular order or arrangement among or between various steps or elements except when the order of individual steps or arrangement of elements is explicitly described. Different arrangements of the components depicted in the drawings or described above, as well as components and steps not shown or described are possible. Similarly, some features and sub-combinations are useful and may be employed without reference to other features and sub-combinations. Embodiments of the invention have been described for illustrative and not restrictive purposes, and alternative embodiments will become apparent to readers of this patent. Accordingly, the present invention is not limited to the embodiments described above or depicted in the drawings, and various embodiments and modifications may be made without departing from the scope of the claims below.