Patent Publication Number: US-2007117183-A1

Title: Corynebacterium glutamicum genes encoding metabolic pathway proteins

Description:
RELATED APPLICATIONS  
      The present application is a divisional application of U.S. patent application Ser. No. 11/055,822, filed Feb. 11, 2005, which is a continuation application of U.S. patent application Ser. No. 09/606,740, filed Jun. 23, 2000, which claims priority to prior filed U.S. Provisional Patent Application Ser. No. 60/141,031, filed Jun. 25, 1999, U.S. Provisional Patent Application Ser. No. 60/142,101, filed Jul. 2, 1999, U.S. Provisional Patent Application Ser. No. 60/148,613, filed Aug. 12, 1999, and also to U.S. Provisional Patent Application Ser. No. 60/187,970, filed Mar. 9, 2000. The present application also claims priority to prior filed German Patent Application No. 19930476.9, filed Jul. 1, 1999, German Patent Application No. 19931415.2, filed Jul. 8, 1999, German Patent Application No. 19931418.7, filed Jul. 8, 1999, German Patent Application No. 19931419.5, filed Jul. 8, 1999, German Patent Application No. 19931420.9, filed Jul. 8, 1999, German Patent Application No. 19931424.1, filed Jul. 8, 1999, German Patent Application No. 19931428.4, filed Jul. 8, 1999, German Patent Application No. 19931434.9, filed Jul. 8, 1999, German Patent Application No. 19931435.7, filed Jul. 8, 1999, German Patent Application No. 19931443.8, filed Jul. 8, 1999, German Patent Application No. 19931453.5, filed Jul. 8, 1999, German Patent Application No. 19931457.8, filed Jul. 8, 1999, German Patent Application No. 19931465.9, filed Jul. 8, 1999, German Patent Application No. 19931478.0, filed Jul. 8, 1999, German Patent Application No. 19931510.8, filed Jul. 8, 1999, German Patent Application No. 19931541.8, filed Jul. 8, 1999, German Patent Application No. 19931573.6, filed Jul. 8, 1999, German Patent Application No. 19931592.2, filed Jul. 8, 1999, German Patent Application No. 19931632.5, filed Jul. 8, 1999, German Patent Application No. 19931634.1, filed Jul. 8, 1999, German Patent Application No. 19931636.8, filed Jul. 8, 1999, German Patent Application No. 19932125.6, filed Jul. 9, 1999, German Patent Application No. 19932126.4, filed Jul. 9, 1999, German Patent Application No. 19932130.2, filed Jul. 9, 1999, German Patent Application No. 19932186.8, filed Jul. 9, 1999, German Patent Application No. 19932206.6, filed Jul. 9, 1999, German Patent Application No. 19932227.9, filed Jul. 9, 1999, German Patent Application No. 19932228.7, filed Jul. 9, 1999, German Patent Application No. 19932229.5, filed Jul. 9, 1999, German Patent Application No. 19932230.9, filed Jul. 9, 1999, German Patent Application No. 19932922.2, filed Jul. 14, 1999, German Patent Application No. 19932926.5, filed Jul. 14, 1999, German Patent Application No. 19932928.1, filed Jul. 14, 1999, German Patent Application No. 19933004.2, filed Jul. 14, 1999, German Patent Application No. 19933005.0, filed Jul. 14, 1999, German Patent Application No. 19933006.9, filed Jul. 14, 1999, German Patent Application No. 19940764.9, filed Aug. 27, 1999, German Patent Application No. 19940765.7, filed Aug. 27, 1999, German Patent Application No. 19940766.5, filed Aug. 27, 1999, German Patent Application No. 19940832.7, filed Aug. 27, 1999, German Patent Application No. 19941378.9, filed Aug. 31, 1999, German Patent Application No. 19941379.7, filed Aug. 31, 1999, German Patent Application No. 19941380.0, filed Aug. 31, 1999, German Patent Application No. 19941394.0, filed Aug. 31, 1999, German Patent Application No. 19941396.7, filed Aug. 31, 1999, German Patent Application No. 19942076.9, filed Sep. 3, 1999, German Patent Application No. 19942077.7, filed Sep. 3, 1999, German Patent Application No. 19942079.3, filed Sep. 3, 1999, German Patent Application No. 19942086.6, filed Sep. 3, 1999, German Patent Application No. 19942087.4, filed Sep. 3, 1999, German Patent Application No. 19942088.2, filed Sep. 3, 1999, German Patent Application No. 19942095.5, filed Sep. 3, 1999, German Patent Application No. 19942124.2, filed Sep. 3, 1999, and German Patent Application No. 19942129.3, filed Sep. 3, 1999. The entire contents of each of the aforementioned applications are hereby expressly incorporated herein by this reference.  
      Incorporation of Material Submitted on Compact Discs  
      This application incorporates herein by reference the material contained on the compact discs submitted herewith as part of this application. Specifically, the file “seqlist” (3.85 MB) contained on each of Copy 1, Copy 2 and the CRF copy of the Sequence Listing is hereby incorporated herein by reference. This file was created on Jul. 29, 2006. In addition, the files “Appendix A” (549 KB) and “Appendix B” (195 KB) contained on each of the compact disks entitled “Appendices Copy 1” and “Appendices Copy 2” are hereby incorporated herein by reference. Each of these files were created on Jul. 29, 2006. 
    
    
     BACKGROUND OF THE INVENTION  
      Certain products and by-products of naturally-occurring metabolic processes in cells have utility in a wide array of industries, including the food, feed, cosmetics, and pharmaceutical industries. These molecules, collectively termed ‘fine chemicals’, include organic acids, both proteinogenic and non-proteinogenic amino acids, nucleotides and nucleosides, lipids and fatty acids, diols, carbohydrates, aromatic compounds, vitamins and cofactors, and enzymes. Their production is most conveniently performed through large-scale culture of bacteria developed to produce and secrete large quantities of a particular desired molecule. One particularly useful organism for this purpose is  Corynebacterium glutamicum , a gram positive, nonpathogenic bacterium. Through strain selection, a number of mutant strains have been developed which produce an array of desirable compounds. However, selection of strains improved for the production of a particular molecule is a time-consuming and difficult process.  
     SUMMARY OF THE INVENTION  
      The invention provides novel bacterial nucleic acid molecules which have a variety of uses. These uses include the identification of microorganisms which can be used to produce fine chemicals, the modulation of fine chemical production in  C. glutamicum  or related bacteria, the typing or identification of  C. glutamicum  or related bacteria, as reference points for mapping the  C. glutamicum  genome, and as markers for transformation. These novel nucleic acid molecules encode proteins, referred to herein as metabolic pathway (MP) proteins.  
       C. glutamicum  is a gram positive, aerobic bacterium which is commonly used in industry for the large-scale production of a variety of fine chemicals, and also for the degradation of hydrocarbons (such as in petroleum spills) and for the oxidation of terpenoids. The MP nucleic acid molecules of the invention, therefore, can be used to identify microorganisms which can be used to produce fine chemicals, e.g., by fermentation processes. Modulation of the expression of the MP nucleic acids of the invention, or modification of the sequence of the MP nucleic acid molecules of the invention, can be used to modulate the production of one or more fine chemicals from a microorganism (e.g., to improve the yield or production of one or more fine chemicals from a  Corynebacterium  or  Brevibacterium  species).  
      The MP nucleic acids of the invention may also be used to identify an organism as being  Corynebacterium glutamicum  or a close relative thereof, or to identify the presence of  C. glutamicum  or a relative thereof in a mixed population of microorganisms. The invention provides the nucleic acid sequences of a number of  C. glutamicum  genes; by probing the extracted genomic DNA of a culture of a unique or mixed population of microorganisms under stringent conditions with a probe spanning a region of a  C. glutamicum  gene which is unique to this organism, one can ascertain whether this organism is present. Although  Corynebacterium glutamicum  itself is nonpathogenic, it is related to species pathogenic in humans, such as  Corynebacterium diphtheriae  (the causative agent of diphtheria); the detection of such organisms is of significant clinical relevance.  
      The MP nucleic acid molecules of the invention may also serve as reference points for mapping of the  C. glutamicum  genome, or of genomes of related organisms. Similarly, these molecules, or variants or portions thereof, may serve as markers for genetically engineered  Corynebacterium  or  Brevibacterium  species. The MP proteins encoded by the novel nucleic acid molecules of the invention are capable of, for example, performing an enzymatic step involved in the metabolism of certain fine chemicals, including amino acids, vitamins, cofactors, nutraceuticals, nucleotides, nucleosides, and trehalose. Given the availability of cloning vectors for use in  Corynebacterium glutamicum , such as those disclosed in Sinskey et al., U.S. Pat. No. 4,649,119, and techniques for genetic manipulation of  C. glutamicum  and the related  Brevibacterium  species (e.g.,  lactofermentum ) (Yoshihama et al,  J. Bacteriol.  162: 591-597 (1985); Katsumata et al.,  J. Bacteriol.  159: 306-311 (1984); and Santamaria et al.,  J. Gen. Microbiol.  130: 2237-2246 (1984)), the nucleic acid molecules of the invention may be utilized in the genetic engineering of this organism to make it a better or more efficient producer of one or more fine chemicals.  
      This improved production or efficiency of production of a fine chemical may be due to a direct effect of manipulation of a gene of the invention, or it may be due to an indirect effect of such manipulation. Specifically, alterations in  C. glutamicum  metabolic pathways for amino acids, vitamins, cofactors, nucleotides, and trehalose may have a direct impact on the overall production of one or more of these desired compounds from this organism. For example, optimizing the activity of a lysine biosynthetic pathway protein or decreasing the activity of a lysine degradative pathway protein may result in an increase in the yield or efficiency of production of lysine from such an engineered organism. Alterations in the proteins involved in these metabolic pathways may also have an indirect impact on the production or efficiency of production of a desired fine chemical. For example, a reaction which is in competition for an intermediate necessary for the production of a desired molecule may be eliminated, or a pathway necessary for the production of a particular intermediate for a desired compound may be optimized. Further, modulations in the biosynthesis or degradation of, for example, an amino acid, a vitamin, or a nucleotide may increase the overall ability of the microorganism to rapidly grow and divide, thus increasing the number and/or production capacities of the microorganism in culture and thereby increasing the possible yield of the desired fine chemical.  
      The nucleic acid and protein molecules of the invention may be utilized to directly improve the production or efficiency of production of one or more desired fine chemicals from  Corynebacterium glutamicum . Using recombinant genetic techniques well known in the art, one or more of the biosynthetic or degradative enzymes of the invention for amino acids, vitamins, cofactors, nutraceuticals, nucleotides, nucleosides, or trehalose may be manipulated such that its function is modulated. For example, a biosynthetic enzyme may be improved in efficiency, or its allosteric control region destroyed such that feedback inhibition of production of the compound is prevented. Similarly, a degradative enzyme may be deleted or modified by substitution, deletion, or addition such that its degradative activity is lessened for the desired compound without impairing the viability of the cell. In each case, the overall yield or rate of production of the desired fine chemical may be increased.  
      It is also possible that such alterations in the protein and nucleotide molecules of the invention may improve the production of other fine chemicals besides the amino acids, vitamins, cofactors, nutraceuticals, nucleotides, nucleosides, and trehalose through indirect mechanisms. Metabolism of any one compound is necessarily intertwined with other biosynthetic and degradative pathways within the cell, and necessary cofactors, intermediates, or substrates in one pathway are likely supplied or limited by another such pathway. Therefore, by modulating the activity of one or more of the proteins of the invention, the production or efficiency of activity of another fine chemical biosynthetic or degradative pathway may be impacted. For example, amino acids serve as the structural units of all proteins, yet may be present intracellularly in levels which are limiting for protein synthesis; therefore, by increasing the efficiency of production or the yields of one or more amino acids within the cell, proteins, such as biosynthetic or degradative proteins, may be more readily synthesized. Likewise, an alteration in a metabolic pathway enzyme such that a particular side reaction becomes more or less favored may result in the over- or under-production of one or more compounds which are utilized as intermediates or substrates for the production of a desired fine chemical.  
      This invention provides novel nucleic acid molecules which encode proteins, referred to herein as metabolic pathway proteins (MP), which are capable of, for example, performing an enzymatic step involved in the metabolism of molecules important for the normal functioning of cells, such as amino acids, vitamins, cofactors, nucleotides and nucleosides, or trehalose. Nucleic acid molecules encoding an MP protein are referred to herein as MP nucleic acid molecules. In a preferred embodiment, the MP protein performs an enzymatic step related to the metabolism of one or more of the following: amino acids, vitamins, cofactors, nutraceuticals, nucleotides, nucleosides, and trehalose. Examples of such proteins include those encoded by the genes set forth in Table 1.  
      Accordingly, one aspect of the invention pertains to isolated nucleic acid molecules (e.g., cDNAs, DNAs, or RNAs) comprising a nucleotide sequence encoding an MP protein or biologically active portions thereof, as well as nucleic acid fragments suitable as primers or hybridization probes for the detection or amplification of MP-encoding nucleic acid (e.g., DNA or mRNA). In particularly preferred embodiments, the isolated nucleic acid molecule comprises one of the nucleotide sequences set forth in Appendix A or the coding region or a complement thereof of one of these nucleotide sequences. In other particularly preferred embodiments, the isolated nucleic acid molecule of the invention comprises a nucleotide sequence which hybridizes to or is at least about 50%, preferably at least about 60%, more preferably at least about 70%, 80% or 90%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to a nucleotide sequence set forth in Appendix A, or a portion thereof. In other preferred embodiments, the isolated nucleic acid molecule encodes one of the amino acid sequences set forth in Appendix B. The preferred MP proteins of the present invention also preferably possess at least one of the MP activities described herein.  
      In another embodiment, the isolated nucleic acid molecule encodes a protein or portion thereof wherein the protein or portion thereof includes an amino acid sequence which is sufficiently homologous to an amino acid sequence of Appendix B, e.g., sufficiently homologous to an amino acid sequence of Appendix B such that the protein or portion thereof maintains an MP activity. Preferably, the protein or portion thereof encoded by the nucleic acid molecule maintains the ability to perform an enzymatic reaction in a amino acid, vitamin, cofactor, nutraceutical, nucleotide, nucleoside, or trehalose metabolic pathway. In one embodiment, the protein encoded by the nucleic acid molecule is at least about 50%, preferably at least about 60%, and more preferably at least about 70%, 80%, or 90% and most preferably at least about 95%, 96%, 97%, 98%, or 99% or more homologous to an amino acid sequence of Appendix B (e.g., an entire amino acid sequence selected from those sequences set forth in Appendix B). In another preferred embodiment, the protein is a full length  C. glutamicum  protein which is substantially homologous to an entire amino acid sequence of Appendix B (encoded by an open reading frame shown in Appendix A).  
      In another preferred embodiment, the isolated nucleic acid molecule is derived from  C. glutamicum  and encodes a protein (e.g., an MP fusion protein) which includes a biologically active domain which is at least about 50% or more homologous to one of the amino acid sequences of Appendix B and is able to catalyze a reaction in a metabolic pathway for an amino acid, vitamin, cofactor, nutraceutical, nucleotide, nucleoside, or trehalose, or one or more of the activities set forth in Table 1, and which also includes heterologous nucleic acid sequences encoding a heterologous polypeptide or regulatory regions.  
      In another embodiment, the isolated nucleic acid molecule is at least 15 nucleotides in length and hybridizes under stringent conditions to a nucleic acid molecule comprising a nucleotide sequence of Appendix A. Preferably, the isolated nucleic acid molecule corresponds to a naturally-occurring nucleic acid molecule. More preferably, the isolated nucleic acid encodes a naturally-occurring  C. glutamicum  MP protein, or a biologically active portion thereof.  
      Another aspect of the invention pertains to vectors, e.g., recombinant expression vectors, containing the nucleic acid molecules of the invention, and host cells into which such vectors have been introduced. In one embodiment, such a host cell is used to produce an MP protein by culturing the host cell in a suitable medium. The MP protein can be then isolated from the medium or the host cell.  
      Yet another aspect of the invention pertains to a genetically altered microorganism in which an MP gene has been introduced or altered. In one embodiment, the genome of the microorganism has been altered by introduction of a nucleic acid molecule of the invention encoding wild-type or mutated MP sequence as a transgene. In another embodiment, an endogenous MP gene within the genome of the microorganism has been altered, e.g., functionally disrupted, by homologous recombination with an altered MP gene. In another embodiment, an endogenous or introduced MP gene in a microorganism has been altered by one or more point mutations, deletions, or inversions, but still encodes a functional MP protein. In still another embodiment, one or more of the regulatory regions (e.g., a promoter, repressor, or inducer) of an MP gene in a microorganism has been altered (e.g., by deletion, truncation, inversion, or point mutation) such that the expression of the MP gene is modulated. In a preferred embodiment, the microorganism belongs to the genus  Corynebacterium  or  Brevibacterium , with  Corynebacterium glutamicum  being particularly preferred. In a preferred embodiment, the microorganism is also utilized for the production of a desired compound, such as an amino acid, with lysine being particularly preferred.  
      In another aspect, the invention provides a method of identifying the presence or activity of  Corynebacterium diphtheriae  in a subject. This method includes detection of one or more of the nucleic acid or amino acid sequences of the invention (e.g., the sequences set forth in Appendix A or Appendix B) in a subject, thereby detecting the presence or activity of  Corynebacterium diphtheriae  in the subject.  
      Still another aspect of the invention pertains to an isolated MP protein or a portion, e.g., a biologically active portion, thereof. In a preferred embodiment, the isolated MP protein or portion thereof can catalyze an enzymatic reaction involved in one or more pathways for the metabolism of an amino acid, a vitamin, a cofactor, a nutraceutical, a nucleotide, a nucleoside, or trehalose. In another preferred embodiment, the isolated MP protein or portion thereof is sufficiently homologous to an amino acid sequence of Appendix B such that the protein or portion thereof maintains the ability to catalyze an enzymatic reaction involved in one or more pathways for the metabolism of an amino acid, a vitamin, a cofactor, a nutraceutical, a nucleotide, a nucleoside, or trehalose.  
      The invention also provides an isolated preparation of an MP protein. In preferred embodiments, the MP protein comprises an amino acid sequence of Appendix B. In another preferred embodiment, the invention pertains to an isolated full length protein which is substantially homologous to an entire amino acid sequence of Appendix B (encoded by an open reading frame set forth in Appendix A). In yet another embodiment, the protein is at least about 50%, preferably at least about 60%, and more preferably at least about 70%, 80%, or 90%, and most preferably at least about 95%, 96%, 97%, 98%, or 99% or more homologous to an entire amino acid sequence of Appendix B. In other embodiments, the isolated MP protein comprises an amino acid sequence which is at least about 50% or more homologous to one of the amino acid sequences of Appendix B and is able to catalyze an enzymatic reaction in an amino acid, vitamin, cofactor, nutraceutical, nucleotide, nucleoside, or trehalose metabolic pathway, or has one or more of the activities set forth in Table 1.  
      Alternatively, the isolated MP protein can comprise an amino acid sequence which is encoded by a nucleotide sequence which hybridizes, e.g., hybridizes under stringent conditions, or is at least about 50%, preferably at least about 60%, more preferably at least about 70%, 80%, or 90%, and even more preferably at least about 95%, 96%, 97%, 98,%, or 99% or more homologous, to a nucleotide sequence of Appendix B. It is also preferred that the preferred forms of MP proteins also have one or more of the MP bioactivities described herein.  
      The MP polypeptide, or a biologically active portion thereof, can be operatively linked to a non-MP polypeptide to form a fusion protein. In preferred embodiments, this fusion protein has an activity which differs from that of the MP protein alone. In other preferred embodiments, this fusion protein, when introduced into a  C. glutamicum  pathway for the metabolism of an amino acid, vitamin, cofactor, nutraceutical, results in increased yields and/or efficiency of production of a desired fine chemical from  C. glutamicum . In particularly preferred embodiments, integration of this fusion protein into an amino acid, vitamin, cofactor, nutraceutical, nucleotide, nucleoside, or trehalose metabolic pathway of a host cell modulates production of a desired compound from the cell.  
      In another aspect, the invention provides methods for screening molecules which modulate the activity of an MP protein, either by interacting with the protein itself or a substrate or binding partner of the MP protein, or by modulating the transcription or translation of an MP nucleic acid molecule of the invention.  
      Another aspect of the invention pertains to a method for producing a fine chemical. This method involves the culturing of a cell containing a vector directing the expression of an MP nucleic acid molecule of the invention, such that a fine chemical is produced. In a preferred embodiment, this method further includes the step of obtaining a cell containing such a vector, in which a cell is transfected with a vector directing the expression of an MP nucleic acid. In another preferred embodiment, this method further includes the step of recovering the fine chemical from the culture. In a particularly preferred embodiment, the cell is from the genus  Corynebacterium  or  Brevibacterium , or is selected from those strains set forth in Table 3.  
      Another aspect of the invention pertains to methods for modulating production of a molecule from a microorganism. Such methods include contacting the cell with an agent which modulates MP protein activity or MP nucleic acid expression such that a cell associated activity is altered relative to this same activity in the absence of the agent. In a preferred embodiment, the cell is modulated for one or more  C. glutamicum  amino acid, vitamin, cofactor, nutraceutical, nucleotide, nucleoside, or trehalose metabolic pathways, such that the yields or rate of production of a desired fine chemical by this microorganism is improved. The agent which modulates MP protein activity can be an agent which stimulates MP protein activity or MP nucleic acid expression. Examples of agents which stimulate MP protein activity or MP nucleic acid expression include small molecules, active MP proteins, and nucleic acids encoding MP proteins that have been introduced into the cell. Examples of agents which inhibit MP activity or expression include small molecules, and antisense MP nucleic acid molecules.  
      Another aspect of the invention pertains to methods for modulating yields of a desired compound from a cell, involving the introduction of a wild-type or mutant MP gene into a cell, either maintained on a separate plasmid or integrated into the genome of the host cell. If integrated into the genome, such integration can be random, or it can take place by homologous recombination such that the native gene is replaced by the introduced copy, causing the production of the desired compound from the cell to be modulated. In a preferred embodiment, said yields are increased. In another preferred embodiment, said chemical is a fine chemical. In a particularly preferred embodiment, said fine chemical is an amino acid. In especially preferred embodiments, said amino acid is L-lysine. 
    
    
     DETAILED DESCRIPTION OF THE INVENTION  
      The present invention provides MP nucleic acid and protein molecules which are involved in the metabolism of certain fine chemicals in  Corynebacterium glutamicum , including amino acids, vitamins, cofactors, nutraceuticals, nucleotides, nucleosides, and trehalose. The molecules of the invention may be utilized in the modulation of production of fine chemicals from microorganisms, such as  C. glutamicum , either directly (e.g., where modulation of the activity of a lysine biosynthesis protein has a direct impact on the production or efficiency of production of lysine from that organism), or may have an indirect impact which nonetheless results in an increase of yield or efficiency of production of the desired compound (e.g., where modulation of the activity of a nucleotide biosynthesis protein has an impact on the production of an organic acid or a fatty acid from the bacterium, perhaps due to improved growth or an increased supply of necessary co-factors, energy compounds, or precursor molecules). Aspects of the invention are further explicated below.  
      I. Fine Chemicals  
      The term ‘fine chemical’ is art-recognized and includes molecules produced by an organism which have applications in various industries, such as, but not limited to, the pharmaceutical, agriculture, and cosmetics industries. Such compounds include organic acids, such as tartaric acid, itaconic acid, and diaminopimelic acid, both proteinogenic and non-proteinogenic amino acids, purine and pyrimidine bases, nucleosides, and nucleotides (as described e.g. in Kuninaka, A. (1996) Nucleotides and related compounds, p. 561-612, in Biotechnology vol. 6, Rehm et al., eds. VCH: Weinheim, and references contained therein), lipids, both saturated and unsaturated fatty acids (e.g., arachidonic acid), diols (e.g., propane diol, and butane diol), carbohydrates (e.g., hyaluronic acid and trehalose), aromatic compounds (e.g., aromatic amines, vanillin, and indigo), vitamins and cofactors (as described in Ullmann&#39;s Encyclopedia of Industrial Chemistry, vol. A27, “Vitamins”, p. 443-613 (1996) VCH: Weinheim and references therein; and Ong, A. S., Niki, E. &amp; Packer, L. (1995) “Nutrition, Lipids, Health, and Disease” Proceedings of the UNESCO/Confederation of Scientific and Technological Associations in Malaysia, and the Society for Free Radical Research—Asia, held Sep. 1-3, 1994 at Penang, Malaysia, AOCS Press, (1995)), enzymes, polyketides (Cane et al. (1998)  Science  282: 63-68), and all other chemicals described in Gutcho (1983) Chemicals by Fermentation, Noyes Data Corporation, ISBN: 0818805086 and references therein. The metabolism and uses of certain of these fine chemicals are further explicated below.  
      A. Amino Acid Metabolism and Uses  
      Amino acids comprise the basic structural units of all proteins, and as such are essential for normal cellular functioning in all organisms. The term “amino acid” is art-recognized. The proteinogenic amino acids, of which there are 20 species, serve as structural units for proteins, in which they are linked by peptide bonds, while the nonproteinogenic amino acids (hundreds of which are known) are not normally found in proteins (see Ulmann&#39;s Encyclopedia of Industrial Chemistry, vol. A2, p. 57-97 VCH: Weinheim (1985)). Amino acids may be in the D- or L-optical configuration, though L-amino acids are generally the only type found in naturally-occurring proteins. Biosynthetic and degradative pathways of each of the 20 proteinogenic amino acids have been well characterized in both prokaryotic and eukaryotic cells (see, for example, Stryer, L. Biochemistry, 3 rd  edition, pages 578-590 (1988)). The ‘essential’ amino acids (histidine, isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine), so named because they are generally a nutritional requirement due to the complexity of their biosyntheses, are readily converted by simple biosynthetic pathways to the remaining 11 ‘nonessential’ amino acids (alanine, arginine, asparagine, aspartate, cysteine, glutamate, glutamine, glycine, proline, serine, and tyrosine). Higher animals do retain the ability to synthesize some of these amino acids, but the essential amino acids must be supplied from the diet in order for normal protein synthesis to occur.  
      Aside from their function in protein biosynthesis, these amino acids are interesting chemicals in their own right, and many have been found to have various applications in the food, feed, chemical, cosmetics, agriculture, and pharmaceutical industries. Lysine is an important amino acid in the nutrition not only of humans, but also of monogastric animals such as poultry and swine. Glutamate is most commonly used as a flavor additive (mono-sodium glutamate, MSG) and is widely used throughout the food industry, as are aspartate, phenylalanine, glycine, and cysteine. Glycine, L-methionine and tryptophan are all utilized in the pharmaceutical industry. Glutamine, valine, leucine, isoleucine, histidine, arginine, proline, serine and alanine are of use in both the pharmaceutical and cosmetics industries. Threonine, tryptophan, and D/L-methionine are common feed additives. (Leuchtenberger, W. (1996) Amino aids—technical production and use, p. 466-502 in Rehm et al. (eds.) Biotechnology vol. 6, chapter 14a, VCH: Weinheim). Additionally, these amino acids have been found to be useful as precursors for the synthesis of synthetic amino acids and proteins, such as N-acetylcysteine, S-carboxymethyl-L-cysteine, (S)-5-hydroxytryptophan, and others described in Ulmann&#39;s Encyclopedia of Industrial Chemistry, vol. A2, p. 57-97, VCH: Weinheim, 1985.  
      The biosynthesis of these natural amino acids in organisms capable of producing them, such as bacteria, has been well characterized (for review of bacterial amino acid biosynthesis and regulation thereof, see Umbarger, H. E.(1978)  Ann. Rev. Biochem.  47: 533-606). Glutamate is synthesized by the reductive amination of α-ketoglutarate, an intermediate in the citric acid cycle. Glutamine, proline, and arginine are each subsequently produced from glutamate. The biosynthesis of serine is a three-step process beginning with 3-phosphoglycerate (an intermediate in glycolysis), and resulting in this amino acid after oxidation, transamination, and hydrolysis steps. Both cysteine and glycine are produced from serine; the former by the condensation of homocysteine with serine, and the latter by the transferal of the side-chain β-carbon atom to tetrahydrofolate, in a reaction catalyzed by serine transhydroxymethylase. Phenylalanine, and tyrosine are synthesized from the glycolytic and pentose phosphate pathway precursors erythrose 4-phosphate and phosphoenolpyruvate in a 9-step biosynthetic pathway that differ only at the final two steps after synthesis of prephenate. Tryptophan is also produced from these two initial molecules, but its synthesis is an 11-step pathway. Tyrosine may also be synthesized from phenylalanine, in a reaction catalyzed by phenylalanine hydroxylase. Alanine, valine, and leucine are all biosynthetic products of pyruvate, the final product of glycolysis. Aspartate is formed from oxaloacetate, an intermediate of the citric acid cycle. Asparagine, methionine, threonine, and lysine are each produced by the conversion of aspartate. Isoleucine is formed from threonine. A complex 9-step pathway results in the production of histidine from 5-phosphoribosyl-1-pyrophosphate, an activated sugar.  
      Amino acids in excess of the protein synthesis needs of the cell cannot be stored, and are instead degraded to provide intermediates for the major metabolic pathways of the cell (for review see Stryer, L. Biochemistry 3 rd  sed. Ch. 21 “Amino Acid Degradation and the Urea Cycle” p. 495-516 (1988)). Although the cell is able to convert unwanted amino acids into useful metabolic intermediates, amino acid production is costly in terms of energy, precursor molecules, and the enzymes necessary to synthesize them. Thus it is not surprising that amino acid biosynthesis is regulated by feedback inhibition, in which the presence of a particular amino acid serves to slow or entirely stop its own production (for overview of feedback mechanisms in amino acid biosynthetic pathways, see Stryer, L. Biochemistry, 3 rd  ed. Ch. 24: “Biosynthesis of Amino Acids and Heme” p. 575-600 (1988)). Thus, the output of any particular amino acid is limited by the amount of that amino acid present in the cell.  
      B. Vitamin, Cofactor, and Nutraceutical Metabolism and Uses  
      Vitamins, cofactors, and nutraceuticals comprise another group of molecules which the higher animals have lost the ability to synthesize and so must ingest, although they are readily synthesized by other organisms, such as bacteria. These molecules are either bioactive substances themselves, or are precursors of biologically active substances which may serve as electron carriers or intermediates in a variety of metabolic pathways. Aside from their nutritive value, these compounds also have significant industrial value as coloring agents, antioxidants, and catalysts or other processing aids. (For an overview of the structure, activity, and industrial applications of these compounds, see, for example, Ullman&#39;s Encyclopedia of Industrial Chemistry, “Vitamins” vol. A27, p. 443-613, VCH: Weinheim, 1996.) The term “vitamin” is art-recognized, and includes nutrients which are required by an organism for normal functioning, but which that organism cannot synthesize by itself. The group of vitamins may encompass cofactors and nutraceutical compounds. The language “cofactor” includes nonproteinaceous compounds required for a normal enzymatic activity to occur. Such compounds may be organic or inorganic; the cofactor molecules of the invention are preferably organic. The term “nutraceutical” includes dietary supplements having health benefits in plants and animals, particularly humans. Examples of such molecules are vitamins, antioxidants, and also certain lipids (e.g., polyunsaturated fatty acids).  
      The biosynthesis of these molecules in organisms capable of producing them, such as bacteria, has been largely characterized (Ullman&#39;s Encyclopedia of Industrial Chemistry, “Vitamins” vol. A27, p. 443-613, VCH: Weinheim, 1996; Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley &amp; Sons; Ong, A. S., Niki, E. &amp; Packer, L. (1995) “Nutrition, Lipids, Health, and Disease” Proceedings of the UNESCO/Confederation of Scientific and Technological Associations in Malaysia, and the Society for Free Radical Research—Asia, held Sep. 1-3, 1994 at Penang, Malaysia, AOCS Press: Champaign, Ill. X, 374 S).  
      Thiamin (vitamin B 1 ) is produced by the chemical coupling of pyrimidine and thiazole moieties. Riboflavin (vitamin B 2 ) is synthesized from guanosine-5′-triphosphate (GTP) and ribose-5′-phosphate. Riboflavin, in turn, is utilized for the synthesis of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). The family of compounds collectively termed ‘vitamin B 6 ’ (e.g., pyridoxine, pyridoxamine, pyridoxa-5′-phosphate, and the commercially used pyridoxin hydrochloride) are all derivatives of the common structural unit, 5-hydroxy-6-methylpyridine. Pantothenate (pantothenic acid, (R)-(+)—N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-β-alanine) can be produced either by chemical synthesis or by fermentation. The final steps in pantothenate biosynthesis consist of the ATP-driven condensation of β-alanine and pantoic acid. The enzymes responsible for the biosynthesis steps for the conversion to pantoic acid, to β-alanine and for the condensation to panthotenic acid are known. The metabolically active form of pantothenate is Coenzyme A, for which the biosynthesis proceeds in 5 enzymatic steps. Pantothenate, pyridoxal-5′-phosphate, cysteine and ATP are the precursors of Coenzyme A. These enzymes not only catalyze the formation of panthothante, but also the production of (R)-pantoic acid, (R)-pantolacton, (R)-panthenol (provitamin B 5 ), pantetheine (and its derivatives) and coenzyme A.  
      Biotin biosynthesis from the precursor molecule pimeloyl-CoA in microorganisms has been studied in detail and several of the genes involved have been identified. Many of the corresponding proteins have been found to also be involved in Fe-cluster synthesis and are members of the nifS class of proteins. Lipoic acid is derived from octanoic acid, and serves as a coenzyme in energy metabolism, where it becomes part of the pyruvate dehydrogenase complex and the α-ketoglutarate dehydrogenase complex. The folates are a group of substances which are all derivatives of folic acid, which is turn is derived from L-glutamic acid, p-amino-benzoic acid and 6-methylpterin. The biosynthesis of folic acid and its derivatives, starting from the metabolism intermediates guanosine-5′-triphosphate (GTP), L-glutamic acid and p-amino-benzoic acid has been studied in detail in certain microorganisms.  
      Corrinoids (such as the cobalamines and particularly vitamin B 12 ) and porphyrines belong to a group of chemicals characterized by a tetrapyrole ring system. The biosynthesis of vitamin B 12  is sufficiently complex that it has not yet been completely characterized, but many of the enzymes and substrates involved are now known. Nicotinic acid (nicotinate), and nicotinamide are pyridine derivatives which are also termed ‘niacin’. Niacin is the precursor of the important coenzymes NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate) and their reduced forms.  
      The large-scale production of these compounds has largely relied on cell-free chemical syntheses, though some of these chemicals have also been produced by large-scale culture of microorganisms, such as riboflavin, Vitamin B 6 , pantothenate, and biotin. Only Vitamin B 12  is produced solely by fermentation, due to the complexity of its synthesis. In vitro methodologies require significant inputs of materials and time, often at great cost.  
      C. Purine, Pyrimidine, Nucleoside and Nucleotide Metabolism and Uses  
      Purine and pyrimidine metabolism genes and their corresponding proteins are important targets for the therapy of tumor diseases and viral infections. The language “purine” or “pyrimidine” includes the nitrogenous bases which are constituents of nucleic acids, co-enzymes, and nucleotides. The term “nucleotide” includes the basic structural units of nucleic acid molecules, which are comprised of a nitrogenous base, a pentose sugar (in the case of RNA, the sugar is ribose; in the case of DNA, the sugar is D-deoxyribose), and phosphoric acid. The language “nucleoside” includes molecules which serve as precursors to nucleotides, but which are lacking the phosphoric acid moiety that nucleotides possess. By inhibiting the biosynthesis of these molecules, or their mobilization to form nucleic acid molecules, it is possible to inhibit RNA and DNA synthesis; by inhibiting this activity in a fashion targeted to cancerous cells, the ability of tumor cells to divide and replicate may be inhibited. Additionally, there are nucleotides which do not form nucleic acid molecules, but rather serve as energy stores (i.e., AMP) or as coenzymes (i.e., FAD and NAD).  
      Several publications have described the use of these chemicals for these medical indications, by influencing purine and/or pyrimidine metabolism (e.g. Christopherson, R. I. and Lyons, S. D. (1990) “Potent inhibitors of de novo pyrimidine and purine biosynthesis as chemotherapeutic agents.”  Med. Res. Reviews  10: 505-548). Studies of enzymes involved in purine and pyrimidine metabolism have been focused on the development of new drugs which can be used, for example, as immunosuppressants or anti-proliferants (Smith, J. L., (1995) “Enzymes in nucleotide synthesis.”  Curr. Opin. Struct. Biol.  5: 752-757; (1995)  Biochem Soc. Transact.  23: 877-902). However, purine and pyrimidine bases, nucleosides and nucleotides have other utilities: as intermediates in the biosynthesis of several fine chemicals (e.g., thiamine, S-adenosyl-methionine, folates, or riboflavin), as energy carriers for the cell (e.g., ATP or GTP), and for chemicals themselves, commonly used as flavor enhancers (e.g., IMP or GMP) or for several medicinal applications (see, for example, Kuninaka, A. (1996) Nucleotides and Related Compounds in Biotechnology vol. 6, Rehm et al., eds. VCH: Weinheim, p. 561-612). Also, enzymes involved in purine, pyrimidine, nucleoside, or nucleotide metabolism are increasingly serving as targets against which chemicals for crop protection, including fungicides, herbicides and insecticides, are developed.  
      The metabolism of these compounds in bacteria has been characterized (for reviews see, for example, Zalkin, H. and Dixon, J. E. (1992) “de novo purine nucleotide biosynthesis”, in: Progress in Nucleic Acid Research and Molecular Biology, vol. 42, Academic Press: p. 259-287; and Michal, G. (1999) “Nucleotides and Nucleosides”, Chapter 8 in: Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, Wiley: New York). Purine metabolism has been the subject of intensive research, and is essential to the normal functioning of the cell. Impaired purine metabolism in higher animals can cause severe disease, such as gout. Purine nucleotides are synthesized from ribose-5-phosphate, in a series of steps through the intermediate compound inosine-5′-phosphate (IMP), resulting in the production of guanosine-5′-monophosphate (GMP) or adenosine-5′-monophosphate (AMP), from which the triphosphate forms utilized as nucleotides are readily formed. These compounds are also utilized as energy stores, so their degradation provides energy for many different biochemical processes in the cell. Pyrimidine biosynthesis proceeds by the formation of uridine-5′-monophosphate (UMP) from ribose-5-phosphate. UMP, in turn, is converted to cytidine-5′-triphosphate (CTP). The deoxy-forms of all of these nucleotides are produced in a one step reduction reaction from the diphosphate ribose form of the nucleotide to the diphosphate deoxyribose form of the nucleotide. Upon phosphorylation, these molecules are able to participate in DNA synthesis.  
      D. Trehalose Metabolism and Uses  
      Trehalose consists of two glucose molecules, bound in α, α-1,1 linkage. It is commonly used in the food industry as a sweetener, an additive for dried or frozen foods, and in beverages. However, it also has applications in the pharmaceutical, cosmetics and biotechnology industries (see, for example, Nishimoto et al., (1998) U.S. Pat. No. 5,759,610; Singer, M. A. and Lindquist, S. (1998)  Trends Biotech.  16: 460-467; Paiva, C. L. A. and Panek, A. D. (1996)  Biotech. Ann. Rev.  2: 293-314; and Shiosaka, M. (1997) J. Japan 172: 97-102). Trehalose is produced by enzymes from many microorganisms and is naturally released into the surrounding medium, from which it can be collected using methods known in the art.  
      II. Elements and Methods of the Invention  
      The present invention is based, at least in part, on the discovery of novel molecules, referred to herein as MP nucleic acid and protein molecules, which play a role in or function in one or more cellular metabolic pathways. In one embodiment, the MP molecules catalyze an enzymatic reaction involving one or more amino acid, vitamin, cofactor, nutraceutical, nucleotide, nucleoside, or trehalose metabolic pathways. In a preferred embodiment, the activity of the MP molecules of the present invention in one or more  C. glutamicum  metabolic pathways for amino acids, vitamins, cofactors, nutraceuticals, nucleotides, nucleosides or trehalose has an impact on the production of a desired fine chemical by this organism. In a particularly preferred embodiment, the MP molecules of the invention are modulated in activity, such that the  C. glutamicum  metabolic pathways in which the MP proteins of the invention are involved are modulated in efficiency or output, which either directly or indirectly modulates the production or efficiency of production of a desired fine chemical by  C. glutamicum.    
      The language, “MP protein” or “MP polypeptide” includes proteins which play a role in, e.g., catalyze an enzymatic reaction, in one or more amino acid, vitamin, cofactor, nutraceutical, nucleotide, nucleoside or trehalose metabolic pathways. Examples of MP proteins include those encoded by the MP genes set forth in Table 1 and Appendix A. The terms “MP gene” or “MP nucleic acid sequence” include nucleic acid sequences encoding an MP protein, which consist of a coding region and also corresponding untranslated 5′ and 3′ sequence regions. Examples of MP genes include those set forth in Table 1. The terms “production” or “productivity” are art-recognized and include the concentration of the fermentation product (for example, the desired fine chemical) formed within a given time and a given fermentation volume (e.g., kg product per hour per liter). The term “efficiency of production” includes the time required for a particular level of production to be achieved (for example, how long it takes for the cell to attain a particular rate of output of a fine chemical). The term “yield” or “product/carbon yield” is art-recognized and includes the efficiency of the conversion of the carbon source into the product (i.e., fine chemical). This is generally written as, for example, kg product per kg carbon source. By increasing the yield or production of the compound, the quantity of recovered molecules, or of useful recovered molecules of that compound in a given amount of culture over a given amount of time is increased. The terms “biosynthesis” or a “biosynthetic pathway” are art-recognized and include the synthesis of a compound, preferably an organic compound, by a cell from intermediate compounds in what may be a multistep and highly regulated process. The terms “degradation” or a “degradation pathway” are art-recognized and include the breakdown of a compound, preferably an organic compound, by a cell to degradation products (generally speaking, smaller or less complex molecules) in what may be a multistep and highly regulated process. The language “metabolism” is art-recognized and includes the totality of the biochemical reactions that take place in an organism. The metabolism of a particular compound, then, (e.g., the metabolism of an amino acid such as glycine) comprises the overall biosynthetic, modification, and degradation pathways in the cell related to this compound.  
      In another embodiment, the MP molecules of the invention are capable of modulating the production of a desired molecule, such as a fine chemical, in a microorganism such as  C. glutamicum . Using recombinant genetic techniques, one or more of the biosynthetic or degradative enzymes of the invention for amino acids, vitamins, cofactors, nutraceuticals, nucleotides, nucleosides, or trehalose may be manipulated such that its function is modulated. For example, a biosynthetic enzyme may be improved in efficiency, or its allosteric control region destroyed such that feedback inhibition of production of the compound is prevented. Similarly, a degradative enzyme may be deleted or modified by substitution, deletion, or addition such that its degradative activity is lessened for the desired compound without impairing the viability of the cell. In each case, the overall yield or rate of production of one of these desired fine chemicals may be increased.  
      It is also possible that such alterations in the protein and nucleotide molecules of the invention may improve the production of other fine chemicals besides the amino acids, vitamins, cofactors, nutraceuticals, nucleotides, nucleosides, and trehalose. Metabolism of any one compound is necessarily intertwined with other biosynthetic and degradative pathways within the cell, and necessary cofactors, intermediates, or substrates in one pathway are likely supplied or limited by another such pathway. Therefore, by modulating the activity of one or more of the proteins of the invention, the production or efficiency of activity of another fine chemical biosynthetic or degradative pathway may be impacted. For example, amino acids serve as the structural units of all proteins, yet may be present intracellularly in levels which are limiting for protein synthesis; therefore, by increasing the efficiency of production or the yields of one or more amino acids within the cell, proteins, such as biosynthetic or degradative proteins, may be more readily synthesized. Likewise, an alteration in a metabolic pathway enzyme such that a particular side reaction becomes more or less favored may result in the over- or under-production of one or more compounds which are utilized as intermediates or substrates for the production of a desired fine chemical.  
      The isolated nucleic acid sequences of the invention are contained within the genome of a  Corynebacterium glutamicum  strain available through the American Type Culture Collection, given designation ATCC 13032. The nucleotide sequence of the isolated  C. glutamicum  MP DNAs and the predicted amino acid sequences of the  C. glutamicum  MP proteins are shown in Appendices A and B, respectively. Computational analyses were performed which classified and/or identified these nucleotide sequences as sequences which encode metabolic pathway proteins.  
      The present invention also pertains to proteins which have an amino acid sequence which is substantially homologous to an amino acid sequence of Appendix B. As used herein, a protein which has an amino acid sequence which is substantially homologous to a selected amino acid sequence is least about 50% homologous to the selected amino acid sequence, e.g., the entire selected amino acid sequence. A protein which has an amino acid sequence which is substantially homologous to a selected amino acid sequence can also be least about 50-60%, preferably at least about 60-70%, and more preferably at least about 70-80%, 80-90%, or 90-95%, and most preferably at least about 96%, 97%, 98%, 99% or more homologous to the selected amino acid sequence.  
      The MP protein or a biologically active portion or fragment thereof of the invention can catalyze an enzymatic reaction in one or more amino acid, vitamin, cofactor, nutraceutical, nucleotide, nucleoside, or trehalose metabolic pathways, or have one or more of the activities set forth in Table 1.  
      Various aspects of the invention are described in further detail in the following subsections:  
      A. Isolated Nucleic Acid Molecules  
      One aspect of the invention pertains to isolated nucleic acid molecules that encode MP polypeptides or biologically active portions thereof, as well as nucleic acid fragments sufficient for use as hybridization probes or primers for the identification or amplification of MP-encoding nucleic acid (e.g., MP DNA). As used herein, the term “nucleic acid molecule” is intended to include DNA molecules (e.g., cDNA or genomic DNA) and RNA molecules (e.g., mRNA) and analogs of the DNA or RNA generated using nucleotide analogs. This term also encompasses untranslated sequence located at both the 3′ and 5′ ends of the coding region of the gene: at least about 100 nucleotides of sequence upstream from the 5′ end of the coding region and at least about 20 nucleotides of sequence downstream from the 3&#39;end of the coding region of the gene. The nucleic acid molecule can be single-stranded or double-stranded, but preferably is double-stranded DNA. An “isolated” nucleic acid molecule is one which is separated from other nucleic acid molecules which are present in the natural source of the nucleic acid. Preferably, an “isolated” nucleic acid is free of sequences which naturally flank the nucleic acid (i.e., sequences located at the 5′ and 3′ ends of the nucleic acid) in the genomic DNA of the organism from which the nucleic acid is derived. For example, in various embodiments, the isolated MP nucleic acid molecule can contain less than about 5 kb, 4 kb, 3 kb, 2 kb, 1 kb, 0.5 kb or 0.1 kb of nucleotide sequences which naturally flank the nucleic acid molecule in genomic DNA of the cell from which the nucleic acid is derived (e.g., a  C. glutamicum  cell). Moreover, an “isolated” nucleic acid molecule, such as a DNA molecule, can be substantially free of other cellular material, or culture medium when produced by recombinant techniques, or chemical precursors or other chemicals when chemically synthesized.  
      A nucleic acid molecule of the present invention, e.g., a nucleic acid molecule having a nucleotide sequence of Appendix A, or a portion thereof, can be isolated using standard molecular biology techniques and the sequence information provided herein. For example, a  C. glutamicum  MP DNA can be isolated from a  C. glutamicum  library using all or portion of one of the sequences of Appendix A as a hybridization probe and standard hybridization techniques (e.g., as described in Sambrook, J., Fritsh, E. F., and Maniatis, T.  Molecular Cloning: A Laboratory Manual.  2 nd, ed., Cold Spring Harbor Laboratory , Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989). Moreover, a nucleic acid molecule encompassing all or a portion of one of the sequences of Appendix A can be isolated by the polymerase chain reaction using oligonucleotide primers designed based upon this sequence (e.g., a nucleic acid molecule encompassing all or a portion of one of the sequences of Appendix A can be isolated by the polymerase chain reaction using oligonucleotide primers designed based upon this same sequence of Appendix A). For example, mRNA can be isolated from normal endothelial cells (e.g., by the guanidinium-thiocyanate extraction procedure of Chirgwin et al. (1979)  Biochemistry  18: 5294-5299) and DNA can be prepared using reverse transcriptase (e.g., Moloney MLV reverse transcriptase, available from Gibco/BRL, Bethesda, Md.; or AMV reverse transcriptase, available from Seikagaku America, Inc., St. Petersburg, Fla.). Synthetic oligonucleotide primers for polymerase chain reaction amplification can be designed based upon one of the nucleotide sequences shown in Appendix A. A nucleic acid of the invention can be amplified using cDNA or, alternatively, genomic DNA, as a template and appropriate oligonucleotide primers according to standard PCR amplification techniques. The nucleic acid so amplified can be cloned into an appropriate vector and characterized by DNA sequence analysis. Furthermore, oligonucleotides corresponding to an MP nucleotide sequence can be prepared by standard synthetic techniques, e.g., using an automated DNA synthesizer.  
      In a preferred embodiment, an isolated nucleic acid molecule of the invention comprises one of the nucleotide sequences shown in Appendix A. The sequences of Appendix A correspond to the  Corynebacterium glutamicum  MP DNAs of the invention. This DNA comprises sequences encoding MP proteins (i.e., the “coding region”, indicated in each sequence in Appendix A), as well as 5′ untranslated sequences and 3′ untranslated sequences, also indicated in Appendix A. Alternatively, the nucleic acid molecule can comprise only the coding region of any of the sequences in Appendix A.  
      For the purposes of this application, it will be understood that each of the sequences set forth in Appendix A has an identifying RXA, RXN, RXS, or RXC number having the designation “RXA”, “RXN”, “RXS”, or “RXC” followed by 5 digits (i.e., RXA00007, RXN00023, RXS00116, or RXC00128). Each of these sequences comprises up to three parts: a 5′ upstream region, a coding region, and a downstream region. Each of these three regions is identified by the same RXA, RXN, RXS, or RXC designation to eliminate confusion. The recitation “one of the sequences in Appendix A”, then, refers to any of the sequences in Appendix A, which may be distinguished by their differing RXA, RXN, RXS, or RXC designations. The coding region of each of these sequences is translated into a corresponding amino acid sequence, which is set forth in Appendix B. The sequences of Appendix B are identified by the same RXA, RXN, RXS, or RXC designations as Appendix A, such that they can be readily correlated. For example, the amino acid sequences in Appendix B designated RXA02229, RX00351, RXS02970, and RXC02390 are translations of the coding regions of the nucleotide sequences of nucleic acid molecules RXA02229, RX00351, RXS02970, and RXC02390, respectively, in Appendix A. Each of the RXA, RXN, RXS, and RXC nucleotide and amino acid sequences of the invention has also been assigned a SEQ ID NO, as indicated in Table 1.  
      Several of the genes of the invention are “F-designated genes”. An F-designated gene includes those genes set forth in Table 1 which have an ‘F’ in front of the RXA, RXN, RXS, or RXC designation. For example, SEQ ID NO:5, designated, as indicated on Table 1, as “F RXA01009”, is an F-designated gene, as are SEQ ID NOs: 73, 75, and 77 (designated on Table 1 as “F RXA00007”, “F RXA00364”, and “F RXA00367”, respectively).  
      In one embodiment, the nucleic acid molecules of the present invention are not intended to include  C. glutamicum  those compiled in Table 2. In the case of the dapD gene, a sequence for this gene was published in Wehrmann, A., et al. (1998)  J. Bacteriol.  180(12): 3159-3165. However, the sequence obtained by the inventors of the present application is significantly longer than the published version. It is believed that the published version relied on an incorrect start codon, and thus represents only a fragment of the actual coding region.  
      In another preferred embodiment, an isolated nucleic acid molecule of the invention comprises a nucleic acid molecule which is a complement of one of the nucleotide sequences shown in Appendix A, or a portion thereof. A nucleic acid molecule which is complementary to one of the nucleotide sequences shown in Appendix A is one which is sufficiently complementary to one of the nucleotide sequences shown in Appendix A such that it can hybridize to one of the nucleotide sequences shown in Appendix A, thereby forming a stable duplex.  
      In still another preferred embodiment, an isolated nucleic acid molecule of the invention comprises a nucleotide sequence which is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to a nucleotide sequence shown in Appendix A, or a portion thereof. Ranges and identity values intermediate to the above-recited ranges, (e.g., 70-90% identical or 80-95% identical) are also intended to be encompassed by the present invention. For example, ranges of identity values using a combination of any of the above values recited as upper and/or lower limits are intended to be included. In an additional preferred embodiment, an isolated nucleic acid molecule of the invention comprises a nucleotide sequence which hybridizes, e.g., hybridizes under stringent conditions, to one of the nucleotide sequences shown in Appendix A, or a portion thereof.  
      Moreover, the nucleic acid molecule of the invention can comprise only a portion of the coding region of one of the sequences in Appendix A, for example a fragment which can be used as a probe or primer or a fragment encoding a biologically active portion of an MP protein. The nucleotide sequences determined from the cloning of the MP genes from  C. glutamicum  allows for the generation of probes and primers designed for use in identifying and/or cloning MP homologues in other cell types and organisms, as well as MP homologues from other  Corynebacteria  or related species. The probe/primer typically comprises substantially purified oligonucleotide. The oligonucleotide typically comprises a region of nucleotide sequence that hybridizes under stringent conditions to at least about 12, preferably about 25, more preferably about 40, 50 or 75 consecutive nucleotides of a sense strand of one of the sequences set forth in Appendix A, an anti-sense sequence of one of the sequences set forth in Appendix A, or naturally occurring mutants thereof. Primers based on a nucleotide sequence of Appendix A can be used in PCR reactions to clone MP homologues. Probes based on the MP nucleotide sequences can be used to detect transcripts or genomic sequences encoding the same or homologous proteins. In preferred embodiments, the probe further comprises a label group attached thereto, e.g. the label group can be a radioisotope, a fluorescent compound, an enzyme, or an enzyme co-factor. Such probes can be used as a part of a diagnostic test kit for identifying cells which misexpress an MP protein, such as by measuring a level of an MP-encoding nucleic acid in a sample of cells from a subject e.g., detecting MP mRNA levels or determining whether a genomic MP gene has been mutated or deleted.  
      In one embodiment, the nucleic acid molecule of the invention encodes a protein or portion thereof which includes an amino acid sequence which is sufficiently homologous to an amino acid sequence of Appendix B such that the protein or portion thereof maintains the ability to catalyze an enzymatic reaction in an amino acid, vitamin, cofactor, nutraceutical, nucleotide, nucleoside, or trehalose metabolic pathway. As used herein, the language “sufficiently homologous” refers to proteins or portions thereof which have amino acid sequences which include a minimum number of identical or equivalent (e.g., an amino acid residue which has a similar side chain as an amino acid residue in one of the sequences of Appendix B) amino acid residues to an amino acid sequence of Appendix B such that the protein or portion thereof is able to catalyze an enzymatic reaction in a  C. glutamicum  amino acid, vitamin, cofactor, nutraceutical, nucleotide, nucleoside or trehalose metabolic pathway. Protein members of such metabolic pathways, as described herein, function to catalyze the biosynthesis or degradation of one or more of: amino acids, vitamins, cofactors, nutraceuticals, nucleotides, nucleosides, or trehalose. Examples of such activities are also described herein. Thus, “the function of an MP protein” contributes to the overall functioning of one or more such metabolic pathway and contributes, either directly or indirectly, to the yield, production, and/or efficiency of production of one or more fine chemicals. Examples of MP protein activities are set forth in Table 1.  
      In another embodiment, the protein is at least about 50-60%, preferably at least about 60-70%, and more preferably at least about 70-80%, 80-90%, 90-95%, and most preferably at least about 96%, 97%, 98%, 99% or more homologous to an entire amino acid sequence of Appendix B.  
      Portions of proteins encoded by the MP nucleic acid molecules of the invention are preferably biologically active portions of one of the MP proteins. As used herein, the term “biologically active portion of an MP protein” is intended to include a portion, e.g., a domain/motif, of an MP protein that catalyzes an enzymatic reaction in one or more  C. glutamicum  amino acid, vitamin, cofactor, nutraceutical, nucleotide, nucleoside, or trehalose metabolic pathways, or has an activity as set forth in Table 1. To determine whether an MP protein or a biologically active portion thereof can catalyze an enzymatic reaction in an amino acid, vitamin, cofactor, nutraceutical, nucleotide, nucleoside, or trehalose metabolic pathway, an assay of enzymatic activity may be performed. Such assay methods are well known to those of ordinary skill in the art, as detailed in Example 8 of the Exemplification.  
      Additional nucleic acid fragments encoding biologically active portions of an MP protein can be prepared by isolating a portion of one of the sequences in Appendix B, expressing the encoded portion of the MP protein or peptide (e.g., by recombinant expression in vitro) and assessing the activity of the encoded portion of the MP protein or peptide.  
      The invention further encompasses nucleic acid molecules that differ from one of the nucleotide sequences shown in Appendix A (and portions thereof) due to degeneracy of the genetic code and thus encode the same MP protein as that encoded by the nucleotide sequences shown in Appendix A. In another embodiment, an isolated nucleic acid molecule of the invention has a nucleotide sequence encoding a protein having an amino acid sequence shown in Appendix B. In a still further embodiment, the nucleic acid molecule of the invention encodes a full length  C. glutamicum  protein which is substantially homologous to an amino acid sequence of Appendix B (encoded by an open reading frame shown in Appendix A).  
      It will be understood by one of ordinary skill in the art that in one embodiment the sequences of the invention are not meant to include the sequences of the prior art, such as those Genbank sequences set forth in Tables 2 or 4 which were available prior to the present invention. In one embodiment, the invention includes nucleotide and amino acid sequences having a percent identity to a nucleotide or amino acid sequence of the invention which is greater than that of a sequence of the prior art (e.g., a Genbank sequence (or the protein encoded by such a sequence) set forth in Tables 2 or 4). For example, the invention includes a nucleotide sequence which is greater than and/or at least 40% identical to the nucleotide sequence designated RXA00115 (SEQ ID NO:185), a nucleotide sequence which is greater than and/or at least % identical to the nucleotide sequence designated RXA00131 (SEQ ID NO:991), and a nucleotide sequence which is greater than and/or at least 39% identical to the nucleotide sequence designated RXA00219 (SEQ ID NO:345). One of ordinary skill in the art would be able to calculate the lower threshold of percent identity for any given sequence of the invention by examining the GAP-calculated percent identity scores set forth in Table 4 for each of the three top hits for the given sequence, and by subtracting the highest GAP-calculated percent identity from 100 percent. One of ordinary skill in the art will also appreciate that nucleic acid and amino acid sequences having percent identities greater than the lower threshold so calculated (e.g., at least 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more identical) are also encompassed by the invention.  
      In addition to the  C. glutamicum  MP nucleotide sequences shown in Appendix A, it will be appreciated by one of ordinary skill in the art that DNA sequence polymorphisms that lead to changes in the amino acid sequences of MP proteins may exist within a population (e.g., the  C. glutamicum  population). Such genetic polymorphism in the MP gene may exist among individuals within a population due to natural variation. As used herein, the terms “gene” and “recombinant gene” refer to nucleic acid molecules comprising an open reading frame encoding an MP protein, preferably a  C. glutamicum  MP protein. Such natural variations can typically result in 1-5% variance in the nucleotide sequence of the MP gene. Any and all such nucleotide variations and resulting amino acid polymorphisms in MP that are the result of natural variation and that do not alter the functional activity of MP proteins are intended to be within the scope of the invention.  
      Nucleic acid molecules corresponding to natural variants and non- C. glutamicum  homologues of the  C. glutamicum  MP DNA of the invention can be isolated based on their homology to the  C. glutamicum  MP nucleic acid disclosed herein using the  C. glutamicum  DNA, or a portion thereof, as a hybridization probe according to standard hybridization techniques under stringent hybridization conditions. Accordingly, in another embodiment, an isolated nucleic acid molecule of the invention is at least 15 nucleotides in length and hybridizes under stringent conditions to the nucleic acid molecule comprising a nucleotide sequence of Appendix A. In other embodiments, the nucleic acid is at least 30, 50, 100, 250 or more nucleotides in length. As used herein, the term “hybridizes under stringent conditions” is intended to describe conditions for hybridization and washing under which nucleotide sequences at least 60% homologous to each other typically remain hybridized to each other. Preferably, the conditions are such that sequences at least about 65%, more preferably at least about 70%, and even more preferably at least about 75% or more homologous to each other typically remain hybridized to each other. Such stringent conditions are known to one of ordinary skill in the art and can be found in Current Protocols in Molecular Biology, John Wiley &amp; Sons, N.Y. (1989), 6.3.1-6.3.6. A preferred, non-limiting example of stringent hybridization conditions are hybridization in 6× sodium chloride/sodium citrate (SSC) at about 45° C., followed by one or more washes in 0.2×SSC, 0.1% SDS at 50-65° C. Preferably, an isolated nucleic acid molecule of the invention that hybridizes under stringent conditions to a sequence of Appendix A corresponds to a naturally-occurring nucleic acid molecule. As used herein, a “naturally-occurring” nucleic acid molecule refers to an RNA or DNA molecule having a nucleotide sequence that occurs in nature (e.g., encodes a natural protein). In one embodiment, the nucleic acid encodes a natural  C. glutamicum  MP protein.  
      In addition to naturally-occurring variants of the MP sequence that may exist in the population, one of ordinary skill in the art will further appreciate that changes can be introduced by mutation into a nucleotide sequence of Appendix A, thereby leading to changes in the amino acid sequence of the encoded MP protein, without altering the functional ability of the MP protein. For example, nucleotide substitutions leading to amino acid substitutions at “non-essential” amino acid residues can be made in a sequence of Appendix A. A “non-essential” amino acid residue is a residue that can be altered from the wild-type sequence of one of the MP proteins (Appendix B) without altering the activity of said MP protein, whereas an “essential” amino acid residue is required for MP protein activity. Other amino acid residues, however, (e.g., those that are not conserved or only semi-conserved in the domain having MP activity) may not be essential for activity and thus are likely to be amenable to alteration without altering MP activity.  
      Accordingly, another aspect of the invention pertains to nucleic acid molecules encoding MP proteins that contain changes in amino acid residues that are not essential for MP activity. Such MP proteins differ in amino acid sequence from a sequence contained in Appendix B yet retain at least one of the MP activities described herein. In one embodiment, the isolated nucleic acid molecule comprises a nucleotide sequence encoding a protein, wherein the protein comprises an amino acid sequence at least about 50% homologous to an amino acid sequence of Appendix B and is capable of catalyzing an enzymatic reaction in an amino acid, vitamin, cofactor, nutraceutical, nucleotide, nucleoside, or trehalose metabolic pathway, or has one or more activities set forth in Table 1. Preferably, the protein encoded by the nucleic acid molecule is at least about 50-60% homologous to one of the sequences in Appendix B, more preferably at least about 60-70% homologous to one of the sequences in Appendix B, even more preferably at least about 70-80%, 80-90%, 90-95% homologous to one of the sequences in Appendix B, and most preferably at least about 96%, 97%, 98%, or 99% homologous to one of the sequences in Appendix B.  
      To determine the percent homology of two amino acid sequences (e.g., one of the sequences of Appendix B and a mutant form thereof) or of two nucleic acids, the sequences are aligned for optimal comparison purposes (e.g., gaps can be introduced in the sequence of one protein or nucleic acid for optimal alignment with the other protein or nucleic acid). The amino acid residues or nucleotides at corresponding amino acid positions or nucleotide positions are then compared. When a position in one sequence (e.g., one of the sequences of Appendix B) is occupied by the same amino acid residue or nucleotide as the corresponding position in the other sequence (e.g., a mutant form of the sequence selected from Appendix B), then the molecules are homologous at that position (i.e., as used herein amino acid or nucleic acid “homology” is equivalent to amino acid or nucleic acid “identity”). The percent homology between the two sequences is a function of the number of identical positions shared by the sequences (i.e., % homology=#of identical positions/total #of positions×100).  
      An isolated nucleic acid molecule encoding an MP protein homologous to a protein sequence of Appendix B can be created by introducing one or more nucleotide substitutions, additions or deletions into a nucleotide sequence of Appendix A such that one or more amino acid substitutions, additions or deletions are introduced into the encoded protein. Mutations can be introduced into one of the sequences of Appendix A by standard techniques, such as site-directed mutagenesis and PCR-mediated mutagenesis. Preferably, conservative amino acid substitutions are made at one or more predicted non-essential amino acid residues. A “conservative amino acid substitution” is one in which the amino acid residue is replaced with an amino acid residue having a similar side chain. Families of amino acid residues having similar side chains have been defined in the art. These families include amino acids with basic side chains (e.g., lysine, arginine, histidine), acidic side chains (e.g., aspartic acid, glutamic acid), uncharged polar side chains (e.g., glycine, asparagine, glutamine, serine, threonine, tyrosine, cysteine), nonpolar side chains (e.g., alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, tryptophan), beta-branched side chains (e.g., threonine, valine, isoleucine) and aromatic side chains (e.g., tyrosine, phenylalanine, tryptophan, histidine). Thus, a predicted nonessential amino acid residue in an MP protein is preferably replaced with another amino acid residue from the same side chain family. Alternatively, in another embodiment, mutations can be introduced randomly along all or part of an MP coding sequence, such as by saturation mutagenesis, and the resultant mutants can be screened for an MP activity described herein to identify mutants that retain MP activity. Following mutagenesis of one of the sequences of Appendix A, the encoded protein can be expressed recombinantly and the activity of the protein can be determined using, for example, assays described herein (see Example 8 of the Exemplification).  
      In addition to the nucleic acid molecules encoding MP proteins described above, another aspect of the invention pertains to isolated nucleic acid molecules which are antisense thereto. An “antisense” nucleic acid comprises a nucleotide sequence which is complementary to a “sense” nucleic acid encoding a protein, e.g., complementary to the coding strand of a double-stranded DNA molecule or complementary to an mRNA sequence. Accordingly, an antisense nucleic acid can hydrogen bond to a sense nucleic acid. The antisense nucleic acid can be complementary to an entire MP coding strand, or to only a portion thereof. In one embodiment, an antisense nucleic acid molecule is antisense to a “coding region” of the coding strand of a nucleotide sequence encoding an MP protein. The term “coding region” refers to the region of the nucleotide sequence comprising codons which are translated into amino acid residues (e.g., the entire coding region of SEQ ID NO. 1 (RXA02229) comprises nucleotides 1 to 825). In another embodiment, the antisense nucleic acid molecule is antisense to a “noncoding region” of the coding strand of a nucleotide sequence encoding MP. The term “noncoding region” refers to 5′ and 3′ sequences which flank the coding region that are not translated into amino acids (i.e., also referred to as 5′ and 3′ untranslated regions).  
      Given the coding strand sequences encoding MP disclosed herein (e.g., the sequences set forth in Appendix A), antisense nucleic acids of the invention can be designed according to the rules of Watson and Crick base pairing. The antisense nucleic acid molecule can be complementary to the entire coding region of MP mRNA, but more preferably is an oligonucleotide which is antisense to only a portion of the coding or noncoding region of MP mRNA. For example, the antisense oligonucleotide can be complementary to the region surrounding the translation start site of MP mRNA. An antisense oligonucleotide can be, for example, about 5, 10, 15, 20, 25, 30, 35, 40, 45 or 50 nucleotides in length. An antisense nucleic acid of the invention can be constructed using chemical synthesis and enzymatic ligation reactions using procedures known in the art. For example, an antisense nucleic acid (e.g., an antisense oligonucleotide) can be chemically synthesized using naturally occurring nucleotides or variously modified nucleotides designed to increase the biological stability of the molecules or to increase the physical stability of the duplex formed between the antisense and sense nucleic acids, e.g., phosphorothioate derivatives and acridine substituted nucleotides can be used. Examples of modified nucleotides which can be used to generate the antisense nucleic acid include 5-fluorouracil, 5-bromouracil, 5-chlorouracil, 5-iodouracil, hypoxanthine, xanthine, 4-acetylcytosine, 5-(carboxyhydroxylmethyl) uracil, 5-carboxymethylaminomethyl-2-thiouridine, 5-carboxymethylaminomethyluracil, dihydrouracil, beta-D-galactosylqueosine, inosine, N6-isopentenyladenine, 1-methylguanine, 1-methylinosine, 2,2-dimethylguanine, 2-methyladenine, 2-methylguanine, 3-methylcytosine, 5-methylcytosine, N6-adenine, 7-methylguanine, 5-methylaminomethyluracil, 5-methoxyaminomethyl-2-thiouracil, beta-D-mannosylqueosine, 5′-methoxycarboxymethyluracil, 5-methoxyuracil, 2-methylthio-N-6-isopentenyladenine, uracil-5-oxyacetic acid (v), wybutoxosine, pseudouracil, queosine, 2-thiocytosine, 5-methyl-2-thiouracil, 2-thiouracil, 4-thiouracil, 5-methyluracil, uracil-5-oxyacetic acid methylester, uracil-5-oxyacetic acid (v), 5-methyl-2-thiouracil, 3-(3-amino-3-N-2-carboxypropyl) uracil, (acp3)w, and 2,6-diaminopurine. Alternatively, the antisense nucleic acid can be produced biologically using an expression vector into which a nucleic acid has been subcloned in an antisense orientation (i.e., RNA transcribed from the inserted nucleic acid will be of an antisense orientation to a target nucleic acid of interest, described further in the following subsection).  
      The antisense nucleic acid molecules of the invention are typically administered to a cell or generated in situ such that they hybridize with or bind to cellular mRNA and/or genomic DNA encoding an MCT protein to thereby inhibit expression of the protein, e.g., by inhibiting transcription and/or translation. The hybridization can be by conventional nucleotide complementarity to form a stable duplex, or, for example, in the case of an antisense nucleic acid molecule which binds to DNA duplexes, through specific interactions in the major groove of the double helix. The antisense molecule can be modified such that it specifically binds to a receptor or an antigen expressed on a selected cell surface, e.g., by linking the antisense nucleic acid molecule to a peptide or an antibody which binds to a cell surface receptor or antigen. The antisense nucleic acid molecule can also be delivered to cells using the vectors described herein. To achieve sufficient intracellular concentrations of the antisense molecules, vector constructs in which the antisense nucleic acid molecule is placed under the control of a strong prokaryotic, viral, or eukaryotic promoter are preferred.  
      In yet another embodiment, the antisense nucleic acid molecule of the invention is an α-anomeric nucleic acid molecule. An α-anomeric nucleic acid molecule forms specific double-stranded hybrids with complementary RNA in which, contrary to the usual β-units, the strands run parallel to each other (Gaultier et al. (1987)  Nucleic Acids. Res.  15:6625-6641). The antisense nucleic acid molecule can also comprise a 2′-o-methylribonucleotide (Inoue et al. (1987)  Nucleic Acids Res.  15:6131-6148) or a chimeric RNA-DNA analogue (Inoue et al. (1987)  FEBS Lett.  215:327-330).  
      In still another embodiment, an antisense nucleic acid of the invention is a ribozyme. Ribozymes are catalytic RNA molecules with ribonuclease activity which are capable of cleaving a single-stranded nucleic acid, such as an mRNA, to which they have a complementary region. Thus, ribozymes (e.g., hammerhead ribozymes (described in Haselhoff and Gerlach (1988)  Nature  334:585-591)) can be used to catalytically cleave MP mRNA transcripts to thereby inhibit translation of MP mRNA. A ribozyme having specificity for an MP-encoding nucleic acid can be designed based upon the nucleotide sequence of an MP DNA disclosed herein (i.e., SEQ ID NO: 1 (RXA02229 in Appendix A). For example, a derivative of a  Tetrahymena  L-19 IVS RNA can be constructed in which the nucleotide sequence of the active site is complementary to the nucleotide sequence to be cleaved in an MP-encoding mRNA. See, e.g., Cech et al. U.S. Pat. No. 4,987,071 and Cech et al. U.S. Pat. No. 5,116,742. Alternatively, MP mRNA can be used to select a catalytic RNA having a specific ribonuclease activity from a pool of RNA molecules. See, e.g., Bartel, D. and Szostak, J. W. (1993)  Science  261:1411-1418.  
      Alternatively, MP gene expression can be inhibited by targeting nucleotide sequences complementary to the regulatory region of an MP nucleotide sequence (e.g., an MP promoter and/or enhancers) to form triple helical structures that prevent transcription of an MP gene in target cells. See generally, Helene, C. (1991)  Anticancer Drug Des.  6(6):569-84; Helene, C. et al. (1992)  Ann. N.Y. Acad. Sci.  660:27-36; and Maher, L. J. (1992)  Bioassays  14(12):807-15.  
      B. Recombinant Expression Vectors and Host Cells  
      Another aspect of the invention pertains to vectors, preferably expression vectors, containing a nucleic acid encoding an MP protein (or a portion thereof). As used herein, the term “vector” refers to a nucleic acid molecule capable of transporting another nucleic acid to which it has been linked. One type of vector is a “plasmid”, which refers to a circular double stranded DNA loop into which additional DNA segments can be ligated. Another type of vector is a viral vector, wherein additional DNA segments can be ligated into the viral genome. Certain vectors are capable of autonomous replication in a host cell into which they are introduced (e.g., bacterial vectors having a bacterial origin of replication and episomal mammalian vectors). Other vectors (e.g., non-episomal mammalian vectors) are integrated into the genome of a host cell upon introduction into the host cell, and thereby are replicated along with the host genome. Moreover, certain vectors are capable of directing the expression of genes to which they are operatively linked. Such vectors are referred to herein as “expression vectors”. In general, expression vectors of utility in recombinant DNA techniques are often in the form of plasmids. In the present specification, “plasmid” and “vector” can be used interchangeably as the plasmid is the most commonly used form of vector. However, the invention is intended to include such other forms of expression vectors, such as viral vectors (e.g., replication defective retroviruses, adenoviruses and adeno-associated viruses), which serve equivalent functions.  
      The recombinant expression vectors of the invention comprise a nucleic acid of the invention in a form suitable for expression of the nucleic acid in a host cell, which means that the recombinant expression vectors include one or more regulatory sequences, selected on the basis of the host cells to be used for expression, which is operatively linked to the nucleic acid sequence to be expressed. Within a recombinant expression vector, “operably linked” is intended to mean that the nucleotide sequence of interest is linked to the regulatory sequence(s) in a manner which allows for expression of the nucleotide sequence (e.g., in an in vitro transcription/translation system or in a host cell when the vector is introduced into the host cell). The term “regulatory sequence” is intended to include promoters, repressor binding sites, activator binding sites, enhancers and other expression control elements (e.g., terminators, polyadenylation signals, or other elements of mRNA secondary structure). Such regulatory sequences are described, for example, in Goeddel;  Gene Expression Technology: Methods in Enzymology  185, Academic Press, San Diego, Calif. (1990). Regulatory sequences include those which direct constitutive expression of a nucleotide sequence in many types of host cell and those which direct expression of the nucleotide sequence only in certain host cells. Preferred regulatory sequences are, for example, promoters such as cos-, tac-, trp-, tet-, trp-tet-, lpp-, lac-, lpp-lac-, lacI q -, T7-, T5-, T3-, gal-, trc-, ara-, SP6-, any, SPO2, λ-P R - or λ P L , which are used preferably in bacteria. Additional regulatory sequences are, for example, promoters from yeasts and fungi, such as ADC1, MFα, AC, P-60, CYC1, GAPDH, TEF, rp28, ADH, promoters from plants such as CaMV/35S, SSU, OCS, lib4, usp, STLS1, B33, nos or ubiquitin- or phaseolin-promoters. It is also possible to use artificial promoters. It will be appreciated by one of ordinary skill in the art that the design of the expression vector can depend on such factors as the choice of the host cell to be transformed, the level of expression of protein desired, etc. The expression vectors of the invention can be introduced into host cells to thereby produce proteins or peptides, including fusion proteins or peptides, encoded by nucleic acids as described herein (e.g., MP proteins, mutant forms of MP proteins, fusion proteins, etc.).  
      The recombinant expression vectors of the invention can be designed for expression of MP proteins in prokaryotic or eukaryotic cells. For example, MP genes can be expressed in bacterial cells such as  C. glutamicum , insect cells (using baculovirus expression vectors), yeast and other fungal cells (see Romanos, M. A. et al. (1992) “Foreign gene expression in yeast: a review”, Yeast 8: 423-488; van den Hondel, C. A. M. J. J. et al. (1991) “Heterologous gene expression in filamentous fungi” in: More Gene Manipulations in Fungi, J. W. Bennet &amp; L. L. Lasure, eds., p. 396-428: Academic Press: San Diego; and van den Hondel, C. A. M. J. J. &amp; Punt, P. J. (1991) “Gene transfer systems and vector development for filamentous fungi, in: Applied Molecular Genetics of Fungi, Peberdy, J. F. et al., eds., p. 1-28, Cambridge University Press: Cambridge), algae and multicellular plant cells (see Schmidt, R. and Willmitzer, L. (1988) High efficiency  Agrobacterium tumefaciens —mediated transformation of  Arabidopsis thaliana  leaf and cotyledon explants”  Plant Cell Rep.:  583-586), or mammalian cells. Suitable host cells are discussed further in Goeddel,  Gene Expression Technology: Methods in Enzymology  185, Academic Press, San Diego, Calif. (1990). Alternatively, the recombinant expression vector can be transcribed and translated in vitro, for example using T7 promoter regulatory sequences and T7 polymerase.  
      Expression of proteins in prokaryotes is most often carried out with vectors containing constitutive or inducible promoters directing the expression of either fusion or non-fusion proteins. Fusion vectors add a number of amino acids to a protein encoded therein, usually to the amino terminus of the recombinant protein but also to the C-terminus or fused within suitable regions in the proteins. Such fusion vectors typically serve three purposes: 1) to increase expression of recombinant protein; 2) to increase the solubility of the recombinant protein; and 3) to aid in the purification of the recombinant protein by acting as a ligand in affinity purification. Often, in fusion expression vectors, a proteolytic cleavage site is introduced at the junction of the fusion moiety and the recombinant protein to enable separation of the recombinant protein from the fusion moiety subsequent to purification of the fusion protein. Such enzymes, and their cognate recognition sequences, include Factor Xa, thrombin and enterokinase.  
      Typical fusion expression vectors include pGEX (Pharmacia Biotech Inc; Smith, D. B. and Johnson, K. S. (1988)  Gene  67:31-40), pMAL (New England Biolabs, Beverly, Mass.) and pRIT5 (Pharmacia, Piscataway, N.J.) which fuse glutathione S-transferase (GST), maltose E binding protein, or protein A, respectively, to the target recombinant protein. In one embodiment, the coding sequence of the MP protein is cloned into a pGEX expression vector to create a vector encoding a fusion protein comprising, from the N-terminus to the C-terminus, GST-thrombin cleavage site-X protein. The fusion protein can be purified by affinity chromatography using glutathione-agarose resin. Recombinant MP protein unfused to GST can be recovered by cleavage of the fusion protein with thrombin.  
      Examples of suitable inducible non-fusion  E. coli  expression vectors include pTrc (Amann et al., (1988)  Gene  69:301-315) pLG338, pACYC184, pBR322, pUC18, pUC19, pKC30, pRep4, pHS1, pHS2, pPLc236, pMBL24, pLG200, pUR290, pIN-III113-B1, λgt11, pBdCl, and pET 11d (Studier et al.,  Gene Expression Technology: Methods in Enzymology  185, Academic Press, San Diego, Calif. (1990) 60-89; and Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018). Target gene expression from the pTrc vector relies on host RNA polymerase transcription from a hybrid trp-lac fusion promoter. Target gene expression from the pET 11d vector relies on transcription from a T7 gn10-lac fusion promoter mediated by a coexpressed viral RNA polymerase (T7 gn1). This viral polymerase is supplied by host strains BL21(DE3) or HMS174(DE3) from a resident λ prophage harboring a T7 gn1 gene under the transcriptional control of the lacUV 5 promoter. For transformation of other varieties of bacteria, appropriate vectors may be selected. For example, the plasmids pIJ101, pIJ364, pIJ702 and pIJ361 are known to be useful in transforming  Streptomyces , while plasmids pUB110, pC194, or pBD214 are suited for transformation of  Bacillus  species. Several plasmids of use in the transfer of genetic information into  Corynebacterium  include pHM1519, pBL1, pSA77, or pAJ667 (Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018).  
      One strategy to maximize recombinant protein expression is to express the protein in a host bacteria with an impaired capacity to proteolytically cleave the recombinant protein (Gottesman, S.,  Gene Expression Technology: Methods in Enzymology  185, Academic Press, San Diego, Calif. (1990) 119-128). Another strategy is to alter the nucleic acid sequence of the nucleic acid to be inserted into an expression vector so that the individual codons for each amino acid are those preferentially utilized in the bacterium chosen for expression, such as  C. glutamicum  (Wada et al. (1992)  Nucleic Acids Res.  20:2111-2118). Such alteration of nucleic acid sequences of the invention can be carried out by standard DNA synthesis techniques.  
      In another embodiment, the MP protein expression vector is a yeast expression vector. Examples of vectors for expression in yeast  S. cerevisiae  include pYepSec1 (Baldari, et al., (1987)  Embo J.  6:229-234), 2μ, pAG-1, Yep6, Yep13, pEMBLYe23, pMFa (Kurjan and Herskowitz, (1982)  Cell  30:933-943), pJRY88 (Schultz et al., (1987)  Gene  54:113-123), and pYES2 (Invitrogen Corporation, San Diego, Calif.). Vectors and methods for the construction of vectors appropriate for use in other fungi, such as the filamentous fungi, include those detailed in: van den Hondel, C. A. M. J. J. &amp; Punt, P. J. (1991) “Gene transfer systems and vector development for filamentous fungi, in: Applied Molecular Genetics of Fungi, J. F. Peberdy, et al., eds., p. 1-28, Cambridge University Press: Cambridge, and Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York (IBSN 0 444 904018).  
      Alternatively, the MP proteins of the invention can be expressed in insect cells using baculovirus expression vectors. Baculovirus vectors available for expression of proteins in cultured insect cells (e.g., Sf 9 cells) include the pAc series (Smith et al. (1983)  Mol. Cell Biol.  3:2156-2165) and the pVL series (Lucklow and Summers (1989)  Virology  170:31-39).  
      In another embodiment, the MP proteins of the invention may be expressed in unicellular plant cells (such as algae) or in plant cells from higher plants (e.g., the spermatophytes, such as crop plants). Examples of plant expression vectors include those detailed in: Becker, D., Kemper, E., Schell, J. and Masterson, R. (1992) “New plant binary vectors with selectable markers located proximal to the left border”,  Plant Mol. Biol.  20: 1195-1197; and Bevan, M. W. (1984) “Binary  Agrobacterium  vectors for plant transformation”,  Nuc. Acid. Res.  12: 8711-8721, and include pLGV23, pGHlac+, pBIN19, pAK2004, and pDH51 (Pouwels et al., eds. (1985) Cloning Vectors. Elsevier: New York IBSN 0 444 904018).  
      In yet another embodiment, a nucleic acid of the invention is expressed in mammalian cells using a mammalian expression vector. Examples of mammalian expression vectors include pCDM8 (Seed, B. (1987)  Nature  329:840) and pMT2PC (Kaufman et al. (1987)  EMBO J.  6:187-195). When used in mammalian cells, the expression vector&#39;s control functions are often provided by viral regulatory elements. For example, commonly used promoters are derived from polyoma, Adenovirus 2, cytomegalovirus and Simian Virus 40. For other suitable expression systems for both prokaryotic and eukaryotic cells see chapters 16 and 17 of Sambrook, J., Fritsh, E. F., and Maniatis, T.  Molecular Cloning: A Laboratory Manual.  2 nd, ed., Cold Spring Harbor Laboratory , Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989.  
      In another embodiment, the recombinant mammalian expression vector is capable of directing expression of the nucleic acid preferentially in a particular cell type (e.g., tissue-specific regulatory elements are used to express the nucleic acid). Tissue-specific regulatory elements are known in the art. Non-limiting examples of suitable tissue-specific promoters include the albumin promoter (liver-specific; Pinkert et al. (1987)  Genes Dev.  1:268-277), lymphoid-specific promoters (Calame and Eaton (1988)  Adv. Immunol.  43:235-275), in particular promoters of T cell receptors (Winoto and Baltimore (1989)  EMBO J.  8:729-733) and immunoglobulins (Banerji et al. (1983)  Cell  33:729-740; Queen and Baltimore (1983)  Cell  33:741-748), neuron-specific promoters (e.g., the neurofilament promoter; Byrne and Ruddle (1989)  PNAS  86:5473-5477), pancreas-specific promoters (Edlund et al. (1985)  Science  230:912-916), and mammary gland-specific promoters (e.g., milk whey promoter; U.S. Pat. No. 4,873,316 and European Application Publication No. 264,166). Developmentally-regulated promoters are also encompassed, for example the murine hox promoters (Kessel and Gruss (1990)  Science  249:374-379) and the α-fetoprotein promoter (Campes and Tilghman (1989)  Genes Dev.  3:537-546).  
      The invention further provides a recombinant expression vector comprising a DNA molecule of the invention cloned into the expression vector in an antisense orientation. That is, the DNA molecule is operatively linked to a regulatory sequence in a manner which allows for expression (by transcription of the DNA molecule) of an RNA molecule which is antisense to MP mRNA. Regulatory sequences operatively linked to a nucleic acid cloned in the antisense orientation can be chosen which direct the continuous expression of the antisense RNA molecule in a variety of cell types, for instance viral promoters and/or enhancers, or regulatory sequences can be chosen which direct constitutive, tissue specific or cell type specific expression of antisense RNA. The antisense expression vector can be in the form of a recombinant plasmid, phagemid or attenuated virus in which antisense nucleic acids are produced under the control of a high efficiency regulatory region, the activity of which can be determined by the cell type into which the vector is introduced. For a discussion of the regulation of gene expression using antisense genes see Weintraub, H. et al., Antisense RNA as a molecular tool for genetic analysis,  Reviews—Trends in Genetics , Vol. 1(1) 1986.  
      Another aspect of the invention pertains to host cells into which a recombinant expression vector of the invention has been introduced. The terms “host cell” and “recombinant host cell” are used interchangeably herein. It is understood that such terms refer not only to the particular subject cell but to the progeny or potential progeny of such a cell. Because certain modifications may occur in succeeding generations due to either mutation or environmental influences, such progeny may not, in fact, be identical to the parent cell, but are still included within the scope of the term as used herein.  
      A host cell can be any prokaryotic or eukaryotic cell. For example, an MP protein can be expressed in bacterial cells such as  C. glutamicum , insect cells, yeast or mammalian cells (such as Chinese hamster ovary cells (CHO) or COS cells). Other suitable host cells are known to those of ordinary skill in the art. Microorganisms related to  Corynebacterium glutamicum  which may be conveniently used as host cells for the nucleic acid and protein molecules of the invention are set forth in Table 3.  
      Vector DNA can be introduced into prokaryotic or eukaryotic cells via conventional transformation or transfection techniques. As used herein, the terms “transformation” and “transfection”, “conjugation” and “transduction” are intended to refer to a variety of art-recognized techniques for introducing foreign nucleic acid (e.g., linear DNA or RNA (e.g., a linearized vector or a gene construct alone without a vector) or nucleic acid in the form of a vector (e.g., a plasmid, phage, phasmid, phagemid, transposon or other DNA) into a host cell, including calcium phosphate or calcium chloride co-precipitation, DEAE-dextran-mediated transfection, lipofection, natural competence, chemical-mediated transfer, or electroporation. Suitable methods for transforming or transfecting host cells can be found in Sambrook, et al. ( Molecular Cloning: A Laboratory Manual.  2 nd, ed., Cold Spring Harbor Laboratory , Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989), and other laboratory manuals.  
      For stable transfection of mammalian cells, it is known that, depending upon the expression vector and transfection technique used, only a small fraction of cells may integrate the foreign DNA into their genome. In order to identify and select these integrants, a gene that encodes a selectable marker (e.g., resistance to antibiotics) is generally introduced into the host cells along with the gene of interest. Preferred selectable markers include those which confer resistance to drugs, such as G418, hygromycin and methotrexate. Nucleic acid encoding a selectable marker can be introduced into a host cell on the same vector as that encoding an MP protein or can be introduced on a separate vector. Cells stably transfected with the introduced nucleic acid can be identified by drug selection (e.g., cells that have incorporated the selectable marker gene will survive, while the other cells die).  
      To create a homologous recombinant microorganism, a vector is prepared which contains at least a portion of an MP gene into which a deletion, addition or substitution has been introduced to thereby alter, e.g., functionally disrupt, the MP gene. Preferably, this MP gene is a  Corynebacterium glutamicum  MP gene, but it can be a homologue from a related bacterium or even from a mammalian, yeast, or insect source. In a preferred embodiment, the vector is designed such that, upon homologous recombination, the endogenous MP gene is functionally disrupted (i.e., no longer encodes a functional protein; also referred to as a “knock out” vector). Alternatively, the vector can be designed such that, upon homologous recombination, the endogenous MP gene is mutated or otherwise altered but still encodes functional protein (e.g., the upstream regulatory region can be altered to thereby alter the expression of the endogenous MP protein). In the homologous recombination vector, the altered portion of the MP gene is flanked at its 5′ and 3′ ends by additional nucleic acid of the MP gene to allow for homologous recombination to occur between the exogenous MP gene carried by the vector and an endogenous MP gene in a microorganism. The additional flanking MP nucleic acid is of sufficient length for successful homologous recombination with the endogenous gene. Typically, several kilobases of flanking DNA (both at the 5′ and 3′ ends) are included in the vector (see e.g., Thomas, K. R., and Capecchi, M. R. (1987) Cell 51: 503 for a description of homologous recombination vectors). The vector is introduced into a microorganism (e.g., by electroporation) and cells in which the introduced MP gene has homologously recombined with the endogenous MP gene are selected, using art-known techniques.  
      In another embodiment, recombinant microorganisms can be produced which contain selected systems which allow for regulated expression of the introduced gene. For example, inclusion of an MP gene on a vector placing it under control of the lac operon permits expression of the MP gene only in the presence of IPTG. Such regulatory systems are well known in the art.  
      In another embodiment, an endogenous MP gene in a host cell is disrupted (e.g., by homologous recombination or other genetic means known in the art) such that expression of its protein product does not occur. In another embodiment, an endogenous or introduced MP gene in a host cell has been altered by one or more point mutations, deletions, or inversions, but still encodes a functional MP protein. In still another embodiment, one or more of the regulatory regions (e.g., a promoter, repressor, or inducer) of an MP gene in a microorganism has been altered (e.g., by deletion, truncation, inversion, or point mutation) such that the expression of the MP gene is modulated. One of ordinary skill in the art will appreciate that host cells containing more than one of the described MP gene and protein modifications may be readily produced using the methods of the invention, and are meant to be included in the present invention.  
      A host cell of the invention, such as a prokaryotic or eukaryotic host cell in culture, can be used to produce (i.e., express) an MP protein. Accordingly, the invention further provides methods for producing MP proteins using the host cells of the invention. In one embodiment, the method comprises culturing the host cell of invention (into which a recombinant expression vector encoding an MP protein has been introduced, or into which genome has been introduced a gene encoding a wild-type or altered MP protein) in a suitable medium until MP protein is produced. In another embodiment, the method further comprises isolating MP proteins from the medium or the host cell.  
      C. Isolated MP Proteins  
      Another aspect of the invention pertains to isolated MP proteins, and biologically active portions thereof. An “isolated” or “purified” protein or biologically active portion thereof is substantially free of cellular material when produced by recombinant DNA techniques, or chemical precursors or other chemicals when chemically synthesized. The language “substantially free of cellular material” includes preparations of MP protein in which the protein is separated from cellular components of the cells in which it is naturally or recombinantly produced. In one embodiment, the language “substantially free of cellular material” includes preparations of MP protein having less than about 30% (by dry weight) of non-MP protein (also referred to herein as a “contaminating protein”), more preferably less than about 20% of non-MP protein, still more preferably less than about 10% of non-MP protein, and most preferably less than about 5% non-MP protein. When the MP protein or biologically active portion thereof is recombinantly produced, it is also preferably substantially free of culture medium, i.e., culture medium represents less than about 20%, more preferably less than about 10%, and most preferably less than about 5% of the volume of the protein preparation. The language “substantially free of chemical precursors or other chemicals” includes preparations of MP protein in which the protein is separated from chemical precursors or other chemicals which are involved in the synthesis of the protein. In one embodiment, the language “substantially free of chemical precursors or other chemicals” includes preparations of MP protein having less than about 30% (by dry weight) of chemical precursors or non-MP chemicals, more preferably less than about 20% chemical precursors or non-MP chemicals, still more preferably less than about 10% chemical precursors or non-MP chemicals, and most preferably less than about 5% chemical precursors or non-MP chemicals. In preferred embodiments, isolated proteins or biologically active portions thereof lack contaminating proteins from the same organism from which the MP protein is derived. Typically, such proteins are produced by recombinant expression of, for example, a  C. glutamicum  MP protein in a microorganism such as  C. glutamicum.    
      An isolated MP protein or a portion thereof of the invention can catalyze an enzymatic reaction in an amino acid, vitamin, cofactor, nutraceutical, nucleotide, nucleoside, or trehalose metabolic pathway, or has one or more of the activities set forth in Table 1. In preferred embodiments, the protein or portion thereof comprises an amino acid sequence which is sufficiently homologous to an amino acid sequence of Appendix B such that the protein or portion thereof maintains the ability to catalyze an enzymatic reaction in an amino acid, vitamin, cofactor, nutraceutical, nucleotide, nucleoside, or trehalose metabolic pathway. The portion of the protein is preferably a biologically active portion as described herein. In another preferred embodiment, an MP protein of the invention has an amino acid sequence shown in Appendix B. In yet another preferred embodiment, the MP protein has an amino acid sequence which is encoded by a nucleotide sequence which hybridizes, e.g., hybridizes under stringent conditions, to a nucleotide sequence of Appendix A. In still another preferred embodiment, the MP protein has an amino acid sequence which is encoded by a nucleotide sequence that is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to one of the nucleic acid sequences of Appendix A, or a portion thereof. Ranges and identity values intermediate to the above-recited values, (e.g., 70-90% identical or 80-95% identical) are also intended to be encompassed by the present invention. For example, ranges of identity values using a combination of any of the above values recited as upper and/or lower limits are intended to be included. The preferred MP proteins of the present invention also preferably possess at least one of the MP activities described herein. For example, a preferred MP protein of the present invention includes an amino acid sequence encoded by a nucleotide sequence which hybridizes, e.g., hybridizes under stringent conditions, to a nucleotide sequence of Appendix A, and which can catalyze an enzymatic reaction in an amino acid, vitamin, cofactor, nutraceutical, nucleotide, nucleoside, or trehalose metabolic pathway, or which has one or more of the activities set forth in Table 1.  
      In other embodiments, the MP protein is substantially homologous to an amino acid sequence of Appendix B and retains the functional activity of the protein of one of the sequences of Appendix B yet differs in amino acid sequence due to natural variation or mutagenesis, as described in detail in subsection I above. Accordingly, in another embodiment, the MP protein is a protein which comprises an amino acid sequence which is at least about 50%, 51%, 52%, 53%, 54%, 55%, 56%, 57%, 58%, 59%, or 60%, preferably at least about 61%, 62%, 63%, 64%, 65%, 66%, 67%, 68%, 69%, or 70%, more preferably at least about 71%, 72%, 73%, 74%, 75%, 76%, 77%, 78%, 79%, or 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, or 90%, or 91%, 92%, 93%, 94%, and even more preferably at least about 95%, 96%, 97%, 98%, 99% or more homologous to an entire amino acid sequence of Appendix B and which has at least one of the MP activities described herein. Ranges and identity values intermediate to the above-recited values, (e.g., 70-90% identical or 80-95% identical) are also intended to be encompassed by the present invention. For example, ranges of identity values using a combination of any of the above values recited as upper and/or lower limits are intended to be included. In another embodiment, the invention pertains to a full length  C. glutamicum  protein which is substantially homologous to an entire amino acid sequence of Appendix B.  
      Biologically active portions of an MP protein include peptides comprising amino acid sequences derived from the amino acid sequence of an MP protein, e.g., the an amino acid sequence shown in Appendix B or the amino acid sequence of a protein homologous to an MP protein, which include fewer amino acids than a full length MP protein or the full length protein which is homologous to an MP protein, and exhibit at least one activity of an MP protein. Typically, biologically active portions (peptides, e.g., peptides which are, for example, 5, 10, 15, 20, 30, 35, 36, 37, 38, 39, 40, 50, 100 or more amino acids in length) comprise a domain or motif with at least one activity of an MP protein. Moreover, other biologically active portions, in which other regions of the protein are deleted, can be prepared by recombinant techniques and evaluated for one or more of the activities described herein. Preferably, the biologically active portions of an MP protein include one or more selected domains/motifs or portions thereof having biological activity.  
      MP proteins are preferably produced by recombinant DNA techniques. For example, a nucleic acid molecule encoding the protein is cloned into an expression vector (as described above), the expression vector is introduced into a host cell (as described above) and the MP protein is expressed in the host cell. The MP protein can then be isolated from the cells by an appropriate purification scheme using standard protein purification techniques. Alternative to recombinant expression, an MP protein, polypeptide, or peptide can be synthesized chemically using standard peptide synthesis techniques. Moreover, native MP protein can be isolated from cells (e.g., endothelial cells), for example using an anti-MP antibody, which can be produced by standard techniques utilizing an MP protein or fragment thereof of this invention.  
      The invention also provides MP chimeric or fusion proteins. As used herein, an MP “chimeric protein” or “fusion protein” comprises an MP polypeptide operatively linked to a non-MP polypeptide. An “MP polypeptide” refers to a polypeptide having an amino acid sequence corresponding to MP, whereas a “non-MP polypeptide” refers to a polypeptide having an amino acid sequence corresponding to a protein which is not substantially homologous to the MP protein, e.g., a protein which is different from the MP protein and which is derived from the same or a different organism. Within the fusion protein, the term “operatively linked” is intended to indicate that the MP polypeptide and the non-MP polypeptide are fused in-frame to each other. The non-MP polypeptide can be fused to the N-terminus or C-terminus of the MP polypeptide. For example, in one embodiment the fusion protein is a GST-MP fusion protein in which the MP sequences are fused to the C-terminus of the GST sequences. Such fusion proteins can facilitate the purification of recombinant MP proteins. In another embodiment, the fusion protein is an MP protein containing a heterologous signal sequence at its N-terminus. In certain host cells (e.g., mammalian host cells), expression and/or secretion of an MP protein can be increased through use of a heterologous signal sequence.  
      Preferably, an MP chimeric or fusion protein of the invention is produced by standard recombinant DNA techniques. For example, DNA fragments coding for the different polypeptide sequences are ligated together in-frame in accordance with conventional techniques, for example by employing blunt-ended or stagger-ended termini for ligation, restriction enzyme digestion to provide for appropriate termini, filling-in of cohesive ends as appropriate, alkaline phosphatase treatment to avoid undesirable joining, and enzymatic ligation. In another embodiment, the fusion gene can be synthesized by conventional techniques including automated DNA synthesizers. Alternatively, PCR amplification of gene fragments can be carried out using anchor primers which give rise to complementary overhangs between two consecutive gene fragments which can subsequently be annealed and reamplified to generate a chimeric gene sequence (see, for example,  Current Protocols in Molecular Biology , eds. Ausubel et al. John Wiley &amp; Sons: 1992). Moreover, many expression vectors are commercially available that already encode a fusion moiety (e.g., a GST polypeptide). An MP-encoding nucleic acid can be cloned into such an expression vector such that the fusion moiety is linked in-frame to the MP protein.  
      Homologues of the MP protein can be generated by mutagenesis, e.g., discrete point mutation or truncation of the MP protein. As used herein, the term “homologue” refers to a variant form of the MP protein which acts as an agonist or antagonist of the activity of the MP protein. An agonist of the MP protein can retain substantially the same, or a subset, of the biological activities of the MP protein. An antagonist of the MP protein can inhibit one or more of the activities of the naturally occurring form of the MP protein, by, for example, competitively binding to a downstream or upstream member of the MP cascade which includes the MP protein. Thus, the  C. glutamicum  MP protein and homologues thereof of the present invention may modulate the activity of one or more metabolic pathways in which MP proteins play a role in this microorganism.  
      In an alternative embodiment, homologues of the MP protein can be identified by screening combinatorial libraries of mutants, e.g., truncation mutants, of the MP protein for MP protein agonist or antagonist activity. In one embodiment, a variegated library of MP variants is generated by combinatorial mutagenesis at the nucleic acid level and is encoded by a variegated gene library. A variegated library of MP variants can be produced by, for example, enzymatically ligating a mixture of synthetic oligonucleotides into gene sequences such that a degenerate set of potential MP sequences is expressible as individual polypeptides, or alternatively, as a set of larger fusion proteins (e.g., for phage display) containing the set of MP sequences therein. There are a variety of methods which can be used to produce libraries of potential MP homologues from a degenerate oligonucleotide sequence. Chemical synthesis of a degenerate gene sequence can be performed in an automatic DNA synthesizer, and the synthetic gene then ligated into an appropriate expression vector. Use of a degenerate set of genes allows for the provision, in one mixture, of all of the sequences encoding the desired set of potential MP sequences. Methods for synthesizing degenerate oligonucleotides are known in the art (see, e.g., Narang, S. A. (1983)  Tetrahedron  39:3; Itakura et al. (1984)  Annu. Rev. Biochem.  53:323; Itakura et al. (1984)  Science  198:1056; Ike et al. (1983)  Nucleic Acid Res.  11:477.  
      In addition, libraries of fragments of the MP protein coding can be used to generate a variegated population of MP fragments for screening and subsequent selection of homologues of an MP protein. In one embodiment, a library of coding sequence fragments can be generated by treating a double stranded PCR fragment of an MP coding sequence with a nuclease under conditions wherein nicking occurs only about once per molecule, denaturing the double stranded DNA, renaturing the DNA to form double stranded DNA which can include sense/antisense pairs from different nicked products, removing single stranded portions from reformed duplexes by treatment with S1 nuclease, and ligating the resulting fragment library into an expression vector. By this method, an expression library can be derived which encodes N-terminal, C-terminal and internal fragments of various sizes of the MP protein.  
      Several techniques are known in the art for screening gene products of combinatorial libraries made by point mutations or truncation, and for screening cDNA libraries for gene products having a selected property. Such techniques are adaptable for rapid screening of the gene libraries generated by the combinatorial mutagenesis of MP homologues. The most widely used techniques, which are amenable to high through-put analysis, for screening large gene libraries typically include cloning the gene library into replicable expression vectors, transforming appropriate cells with the resulting library of vectors, and expressing the combinatorial genes under conditions in which detection of a desired activity facilitates isolation of the vector encoding the gene whose product was detected. Recursive ensemble mutagenesis (REM), a new technique which enhances the frequency of functional mutants in the libraries, can be used in combination with the screening assays to identify MP homologues (Arkin and Yourvan (1992)  PNAS  89:7811-7815; Delgrave et al. (1993)  Protein Engineering  6(3):327-331).  
      In another embodiment, cell based assays can be exploited to analyze a variegated MP library, using methods well known in the art.  
      D. Uses and Methods of the Invention  
      The nucleic acid molecules, proteins, protein homologues, fusion proteins, primers, vectors, and host cells described herein can be used in one or more of the following methods: identification of  C. glutamicum  and related organisms; mapping of genomes of organisms related to  C. glutamicum ; identification and localization of  C. glutamicum  sequences of interest; evolutionary studies; determination of MP protein regions required for function; modulation of an MP protein activity; modulation of the activity of an MP pathway; and modulation of cellular production of a desired compound, such as a fine chemical.  
      The MP nucleic acid molecules of the invention have a variety of uses. First, they may be used to identify an organism as being  Corynebacterium glutamicum  or a close relative thereof. Also, they may be used to identify the presence of  C. glutamicum  or a relative thereof in a mixed population of microorganisms. The invention provides the nucleic acid sequences of a number of  C. glutamicum  genes; by probing the extracted genomic DNA of a culture of a unique or mixed population of microorganisms under stringent conditions with a probe spanning a region of a  C. glutamicum  gene which is unique to this organism, one can ascertain whether this organism is present. Although  Corynebacterium glutamicum  itself is not pathogenic to humans, it is related to species which are human pathogens, such as  Corynebacterium diphtheriae. Corynebacterium diphtheriae  is the causative agent of diphtheria, a rapidly developing, acute, febrile infection which involves both local and systemic pathology. In this disease, a local lesion develops in the upper respiratory tract and involves necrotic injury to epithelial cells; the bacilli secrete toxin which is disseminated through this lesion to distal susceptible tissues of the body. Degenerative changes brought about by the inhibition of protein synthesis in these tissues, which include heart, muscle, peripheral nerves, adrenals, kidneys, liver and spleen, result in the systemic pathology of the disease. Diphtheria continues to have high incidence in many parts of the world, including Africa, Asia, Eastern Europe and the independent states of the former Soviet Union. An ongoing epidemic of diphtheria in the latter two regions has resulted in at least 5,000 deaths since 1990.  
      In one embodiment, the invention provides a method of identifying the presence or activity of  Corynebacterium diphtheriae  in a subject. This method includes detection of one or more of the nucleic acid or amino acid sequences of the invention (e.g., the sequences set forth in Appendix A or Appendix B) in a subject, thereby detecting the presence or activity of  Corynebacterium diphtheriae  in the subject.  C. glutamicum  and  C. diphtheriae  are related bacteria, and many of the nucleic acid and protein molecules in  C. glutamicum  are homologous to  C. diphtheriae  nucleic acid and protein molecules, and can therefore be used to detect  C. diphtheriae  in a subject.  
      The nucleic acid and protein molecules of the invention may also serve as markers for specific regions of the genome. This has utility not only in the mapping of the genome, but also for functional studies of  C. glutamicum  proteins. For example, to identify the region of the genome to which a particular  C. glutamicum  DNA-binding protein binds, the  C. glutamicum  genome could be digested, and the fragments incubated with the DNA-binding protein. Those which bind the protein may be additionally probed with the nucleic acid molecules of the invention, preferably with readily detectable labels; binding of such a nucleic acid molecule to the genome fragment enables the localization of the fragment to the genome map of  C. glutamicum , and, when performed multiple times with different enzymes, facilitates a rapid determination of the nucleic acid sequence to which the protein binds. Further, the nucleic acid molecules of the invention may be sufficiently homologous to the sequences of related species such that these nucleic acid molecules may serve as markers for the construction of a genomic map in related bacteria, such as  Brevibacterium lactofermentum.    
      The MP nucleic acid molecules of the invention are also useful for evolutionary and protein structural studies. The metabolic processes in which the molecules of the invention participate are utilized by a wide variety of prokaryotic and eukaryotic cells; by comparing the sequences of the nucleic acid molecules of the present invention to those encoding similar enzymes from other organisms, the evolutionary relatedness of the organisms can be assessed. Similarly, such a comparison permits an assessment of which regions of the sequence are conserved and which are not, which may aid in determining those regions of the protein which are essential for the functioning of the enzyme. This type of determination is of value for protein engineering studies and may give an indication of what the protein can tolerate in terms of mutagenesis without losing function.  
      Manipulation of the MP nucleic acid molecules of the invention may result in the production of MP proteins having functional differences from the wild-type MP proteins. These proteins may be improved in efficiency or activity, may be present in greater numbers in the cell than is usual, or may be decreased in efficiency or activity.  
      The invention also provides methods for screening molecules which modulate the activity of an MP protein, either by interacting with the protein itself or a substrate or binding partner of the MP protein, or by modulating the transcription or translation of an MP nucleic acid molecule of the invention. In such methods, a microorganism expressing one or more MP proteins of the invention is contacted with one or more test compounds, and the effect of each test compound on the activity or level of expression of the MP protein is assessed.  
      When the desired fine chemical to be isolated from large-scale fermentative culture of  C. glutamicum  is an amino acid, a vitamin, a cofactor, a nutraceutical, a nucleotide, a nucleoside, or trehalose, modulation of the activity or efficiency of activity of one or more of the proteins of the invention by recombinant genetic mechanisms may directly impact the production of one of these fine chemicals. For example, in the case of an enzyme in a biosynthetic pathway for a desired amino acid, improvement in efficiency or activity of the enzyme (including the presence of multiple copies of the gene) should lead to an increased production or efficiency of production of that desired amino acid. In the case of an enzyme in a biosynthetic pathway for an amino acid whose synthesis is in competition with the synthesis of a desired amino acid, any decrease in the efficiency or activity of this enzyme (including deletion of the gene) should result in an increase in production or efficiency of production of the desired amino acid, due to decreased competition for intermediate compounds and/or energy. In the case of an enzyme in a degradation pathway for a desired amino acid, any decrease in efficiency or activity of the enzyme should result in a greater yield or efficiency of production of the desired product due to a decrease in its degradation. Lastly, mutagenesis of an enzyme involved in the biosynthesis of a desired amino acid such that this enzyme is no longer is capable of feedback inhibition should result in increased yields or efficiency of production of the desired amino acid. The same should apply to the biosynthetic and degradative enzymes of the invention involved in the metabolism of vitamins, cofactors, nutraceuticals, nucleotides, nucleosides and trehalose.  
      Similarly, when the desired fine chemical is not one of the aforementioned compounds, the modulation of activity of one of the proteins of the invention may still impact the yield and/or efficiency of production of the compound from large-scale culture of  C. glutamicum . The metabolic pathways of any organism are closely interconnected; the intermediate used by one pathway is often supplied by a different pathway. Enzyme expression and function may be regulated based on the cellular levels of a compound from a different metabolic process, and the cellular levels of molecules necessary for basic growth, such as amino acids and nucleotides, may critically affect the viability of the microorganism in large-scale culture. Thus, modulation of an amino acid biosynthesis enzyme, for example, such that it is no longer responsive to feedback inhibition or such that it is improved in efficiency or turnover may result in increased cellular levels of one or more amino acids. In turn, this increased pool of amino acids provides not only an increased supply of molecules necessary for protein synthesis, but also of molecules which are utilized as intermediates and precursors in a number of other biosynthetic pathways. If a particular amino acid had been limiting in the cell, its increased production might increase the ability of the cell to perform numerous other metabolic reactions, as well as enabling the cell to more efficiently produce proteins of all kinds, possibly increasing the overall growth rate or survival ability of the cell in large scale culture. Increased viability improves the number of cells capable of producing the desired fine chemical in fermentative culture, thereby increasing the yield of this compound. Similar processes are possible by the modulation of activity of a degradative enzyme of the invention such that the enzyme no longer catalyzes, or catalyzes less efficiently, the degradation of a cellular compound which is important for the biosynthesis of a desired compound, or which will enable the cell to grow and reproduce more efficiently in large-scale culture. It should be emphasized that optimizing the degradative activity or decreasing the biosynthetic activity of certain molecules of the invention may also have a beneficial effect on the production of certain fine chemicals from  C. glutamicum . For example, by decreasing the efficiency of activity of a biosynthetic enzyme in a pathway which competes with the biosynthetic pathway of a desired compound for one or more intermediates, more of those intermediates should be available for conversion to the desired product. A similar situation may call for the improvement of degradative ability or efficiency of one or more proteins of the invention.  
      This aforementioned list of mutagenesis strategies for MP proteins to result in increased yields of a desired compound is not meant to be limiting; variations on these mutagenesis strategies will be readily apparent to one of ordinary skill in the art. By these mechanisms, the nucleic acid and protein molecules of the invention may be utilized to generate  C. glutamicum  or related strains of bacteria expressing mutated MP nucleic acid and protein molecules such that the yield, production, and/or efficiency of production of a desired compound is improved. This desired compound may be any natural product of  C. glutamicum , which includes the final products of biosynthesis pathways and intermediates of naturally-occurring metabolic pathways, as well as molecules which do not naturally occur in the metabolism of  C. glutamicum , but which are produced by a  C. glutamicum  strain of the invention.  
      This invention is further illustrated by the following examples which should not be construed as limiting. The contents of all references, patent applications, patents, published patent applications, Tables, Appendices, and the sequence listing cited throughout this application are hereby incorporated by reference.  
      Exemplification  
     EXAMPLE 1  
     Preparation of Total Genomic DNA of  Corynebacterium glutamicum  ATCC 13032  
      A culture of  Corynebacterium glutamicum  (ATCC 13032) was grown overnight at 30° C. with vigorous shaking in BHI medium (Difco). The cells were harvested by centrifugation, the supernatant was discarded and the cells were resuspended in 5 ml buffer-I (5% of the original volume of the culture—all indicated volumes have been calculated for 100 ml of culture volume). Composition of buffer-I: 140.34 g/l sucrose, 2.46 g/l MgSO 4 ×7H 2 O, 10 ml/l KH 2 PO 4  solution (100 g/l, adjusted to pH 6.7 with KOH), 50 ml/l M12 concentrate (10 g/l (NH 4 ) 2 SO 4 , 1 g/l NaCl, 2 g/l MgSO 4 ×7H 2 O, 0.2 g/l CaCl 2 , 0.5 g/l yeast extract (Difco), 10 ml/l trace-elements-mix (200 mg/l FeSO 4 ×H 2 O, 10 mg/l ZnSO 4 ×7H 2 O, 3 mg/l MnCl 2 ×4H 2 O, 30 mg/l H 3 BO 3  20 mg/l CoCl 2 ×6H 2 O, 1 mg/l NiCl 2 ×6H 2 O, 3 mg/l Na 2 MoO 4 ×2H 2 O, 500 mg/l complexing agent (EDTA or critic acid), 100 ml/l vitamins-mix (0.2 mg/l biotin, 0.2 mg/l folic acid, 20 mg/l p-amino benzoic acid, 20 mg/l riboflavin, 40 mg/l ca-panthothenate, 140 mg/l nicotinic acid, 40 mg/l pyridoxole hydrochloride, 200 mg/l myo-inositol). Lysozyme was added to the suspension to a final concentration of 2.5 mg/ml. After an approximately 4 h incubation at 37° C., the cell wall was degraded and the resulting protoplasts are harvested by centrifugation. The pellet was washed once with 5 ml buffer-I and once with 5 ml TE-buffer (10 mM Tris-HCl, 1 mM EDTA, pH 8). The pellet was resuspended in 4 ml TE-buffer and 0.5 ml SDS solution (10%) and 0.5 ml NaCl solution (5 M) are added. After adding of proteinase K to a final concentration of 200 g/ml, the suspension is incubated for ca.18 h at 37° C. The DNA was purified by extraction with phenol, phenol-chloroform-isoamylalcohol and chloroform-isoamylalcohol using standard procedures. Then, the DNA was precipitated by adding 1/50 volume of 3 M sodium acetate and 2 volumes of ethanol, followed by a 30 min incubation at −20° C. and a 30 min centrifugation at 12,000 rpm in a high speed centrifuge using a SS34 rotor (Sorvall). The DNA was dissolved in 1 ml TE-buffer containing 20 μg/ml RNaseA and dialysed at 4° C. against 1000 ml TE-buffer for at least 3 hours. During this time, the buffer was exchanged 3 times. To aliquots of 0.4 ml of the dialysed DNA solution, 0.4 ml of 2 M LiCl and 0.8 ml of ethanol are added. After a 30 min incubation at −20° C., the DNA was collected by centrifugation (13,000 rpm, Biofuge Fresco, Heraeus, Hanau, Germany). The DNA pellet was dissolved in TE-buffer. DNA prepared by this procedure could be used for all purposes, including southern blotting or construction of genomic libraries.  
     EXAMPLE 2  
     Construction of Genomic Libraries in  Escherichia Coli  of  Corynebacterium glutamicum  ATCC13032  
      Using DNA prepared as described in Example 1, cosmid and plasmid libraries were constructed according to known and well established methods (see e.g., Sambrook, J. et al. (1989) “Molecular Cloning: A Laboratory Manual”, Cold Spring Harbor Laboratory Press, or Ausubel, F. M. et al. (1994) “Current Protocols in Molecular Biology”, John Wiley &amp; Sons.)  
      Any plasmid or cosmid could be used. Of particular use were the plasmids pBR322 (Sutcliffe, J. G. (1979)  Proc. Natl. Acad. Sci. USA,  75:3737-3741); pACYC177 (Change &amp; Cohen (1978)  J. Bacteriol  134:1141-1156), plasmids of the pBS series (pBSSK+, pBSSK− and others; Stratagene, LaJolla, USA), or cosmids as SuperCos1 (Stratagene, LaJolla, USA) or Lorist6 (Gibson, T. J., Rosenthal A. and Waterson, R. H. (1987)  Gene  53:283-286. Gene libraries specifically for use in  C. glutamicum  may be constructed using plasmid pSL109 (Lee, H.-S. and A. J. Sinskey (1994)  J. Microbiol. Biotechnol.  4: 256-263).  
     EXAMPLE 3  
     DNA Sequencing and Computational Functional Analysis  
      Genomic libraries as described in Example 2 were used for DNA sequencing according to standard methods, in particular by the chain termination method using ABI377 sequencing machines (see e.g., Fleischman, R. D. et al. (1995) “Whole-genome Random Sequencing and Assembly of  Haemophilus Influenzae  Rd.,  Science,  269:496-512). Sequencing primers with the following nucleotide sequences were used: 5′-GGAAACAGTATGACCATG-3′ or 5′-GTAAAACGACGGCCAGT-3′.  
     EXAMPLE 4  
     In Vivo Mutagenesis  
      In vivo mutagenesis of  Corynebacterium glutamicum  can be performed by passage of plasmid (or other vector) DNA through  E. coli  or other microorganisms (e.g.  Bacillus  spp. or yeasts such as  Saccharomyces cerevisiae ) which are impaired in their capabilities to maintain the integrity of their genetic information. Typical mutator strains have mutations in the genes for the DNA repair system (e.g., mutHLS, mutD, mutT, etc.; for reference, see Rupp, W. D. (1996) DNA repair mechanisms, in:  Escherichia coli  and  Salmonella , p. 2277-2294, ASM: Washington.) Such strains are well known to those of ordinary skill in the art. The use of such strains is illustrated, for example, in Greener, A. and Callahan, M. (1994)  Strategies  7: 32-34.  
     EXAMPLE 5  
     DNA Transfer Between  Escherichia coli  and  Corynebacterium glutamicum    
      Several  Corynebacterium  and  Brevibacterium  species contain endogenous plasmids (as e.g., pHM1519 or pBL1) which replicate autonomously (for review see, e.g., Martin, J. F. et al. (1987)  Biotechnology,  5:137-146). Shuttle vectors for  Escherichia coli  and  Corynebacterium glutamicum  can be readily constructed by using standard vectors for  E. coli  (Sambrook, J. et al. (1989), “Molecular Cloning: A Laboratory Manual”, Cold Spring Harbor Laboratory Press or Ausubel, F. M. et al. (1994) “Current Protocols in Molecular Biology”, John Wiley &amp; Sons) to which a origin or replication for and a suitable marker from  Corynebacterium glutamicum  is added. Such origins of replication are preferably taken from endogenous plasmids isolated from  Corynebacterium  and  Brevibacterium  species. Of particular use as transformation markers for these species are genes for kanamycin resistance (such as those derived from the Tn5 or Tn903 transposons) or chloramphenicol (Winnacker, E. L. (1987) “From Genes to Clones Introduction to Gene Technology, VCH, Weinheim). There are numerous examples in the literature of the construction of a wide variety of shuttle vectors which replicate in both  E. coli  and  C. glutamicum , and which can be used for several purposes, including gene over-expression (for reference, see e.g., Yoshihama, M. et al. (1985)  J. Bacteriol.  162:591-597, Martin J. F. et al. (1987)  Biotechnology,  5:137-146 and Eikmanns, B. J. et al. (1991)  Gene,  102:93-98).  
      Using standard methods, it is possible to clone a gene of interest into one of the shuttle vectors described above and to introduce such a hybrid vectors into strains of  Corynebacterium glutamicum . Transformation of  C. glutamicum  can be achieved by protoplast transformation (Kastsumata, R. et al. (1984)  J. Bacteriol.  159306-311), electroporation (Liebl, E. et al. (1989)  FEMS Microbiol. Letters,  53:399-303) and in cases where special vectors are used, also by conjugation (as described e.g. in Schäfer, A et al. (1990)  J. Bacteriol.  172:1663-1666). It is also possible to transfer the shuttle vectors for  C. glutamicum  to  E. coli  by preparing plasmid DNA from  C. glutamicum  (using standard methods well-known in the art) and transforming it into  E. coli . This transformation step can be performed using standard methods, but it is advantageous to use an Mcr-deficient  E. coli  strain, such as NM522 (Gough &amp; Murray (1983)  J. Mol. Biol.  166:1-19).  
      Genes may be overexpressed in  C. glutamicum  strains using plasmids which comprise pCG1 (U.S. Pat. No. 4,617,267) or fragments thereof, and optionally the gene for kanamycin resistance from TN903 (Grindley, N. D. and Joyce, C. M. (1980)  Proc. Natl. Acad. Sci. USA  77(12): 7176-7180). In addition, genes may be overexpressed in  C. glutamicum  strains using plasmid pSL109 (Lee, H.-S. and A. J. Sinskey (1994)  J. Microbiol. Biotechnol.  4: 256-263).  
      Aside from the use of replicative plasmids, gene overexpression can also be achieved by integration into the genome. Genomic integration in  C. glutamicum  or other  Corynebacterium  or  Brevibacterium  species may be accomplished by well-known methods, such as homologous recombination with genomic region(s), restriction endonuclease mediated integration (REMI) (see, e.g., DE Pat. 19823834), or through the use of transposons. It is also possible to modulate the activity of a gene of interest by modifying the regulatory regions (e.g., a promoter, a repressor, and/or an enhancer) by sequence modification, insertion, or deletion using site-directed methods (such as homologous recombination) or methods based on random events (such as transposon mutagenesis or REMI). Nucleic acid sequences which function as transcriptional terminators may also be inserted 3′ to the coding region of one or more genes of the invention; such terminators are well-known in the art and are described, for example, in Winnacker, E. L. (1987) From Genes to Clones—Introduction to Gene Technology. VCH: Weinheim.  
     EXAMPLE 6  
     Assessment of the Expression of the Mutant Protein  
      Observations of the activity of a mutated protein in a transformed host cell rely on the fact that the mutant protein is expressed in a similar fashion and in a similar quantity to that of the wild-type protein. A useful method to ascertain the level of transcription of the mutant gene (an indicator of the amount of mRNA available for translation to the gene product) is to perform a Northern blot (for reference see, for example, Ausubel et al. (1988) Current Protocols in Molecular Biology, Wiley: New York), in which a primer designed to bind to the gene of interest is labeled with a detectable tag (usually radioactive or chemiluminescent), such that when the total RNA of a culture of the organism is extracted, run on gel, transferred to a stable matrix and incubated with this probe, the binding and quantity of binding of the probe indicates the presence and also the quantity of mRNA for this gene. This information is evidence of the degree of transcription of the mutant gene. Total cellular RNA can be prepared from  Corynebacterium glutamicum  by several methods, all well-known in the art, such as that described in Bormann, E. R. et al. (1992)  Mol. Microbiol.  6: 317-326.  
      To assess the presence or relative quantity of protein translated from this mRNA, standard techniques, such as a Western blot, may be employed (see, for example, Ausubel et al. (1988) Current Protocols in Molecular Biology, Wiley: New York). In this process, total cellular proteins are extracted, separated by gel electrophoresis, transferred to a matrix such as nitrocellulose, and incubated with a probe, such as an antibody, which specifically binds to the desired protein. This probe is generally tagged with a chemiluminescent or colorimetric label which may be readily detected. The presence and quantity of label observed indicates the presence and quantity of the desired mutant protein present in the cell.  
     EXAMPLE 7  
     Growth of Genetically Modified  Corynebacterium glutamicum  —Media and Culture Conditions  
      Genetically modified  Corynebacteria  are cultured in synthetic or natural growth media. A number of different growth media for  Corynebacteria  are both well-known and readily available (Lieb et al. (1989)  Appl. Microbiol. Biotechnol.,  32:205-210; von der Osten et al. (1998) Biotechnology Letters, 11:11-16; Pat. DE 4,120,867; Liebl (1992) “The Genus  Corynebacterium , in: The Procaryotes, Volume II, Balows, A. et al., eds. Springer-Verlag). These media consist of one or more carbon sources, nitrogen sources, inorganic salts, vitamins and trace elements. Preferred carbon sources are sugars, such as mono-, di-, or polysaccharides. For example, glucose, fructose, mannose, galactose, ribose, sorbose, ribulose, lactose, maltose, sucrose, raffinose, starch or cellulose serve as very good carbon sources. It is also possible to supply sugar to the media via complex compounds such as molasses or other by-products from sugar refinement. It can also be advantageous to supply mixtures of different carbon sources. Other possible carbon sources are alcohols and organic acids, such as methanol, ethanol, acetic acid or lactic acid. Nitrogen sources are usually organic or inorganic nitrogen compounds, or materials which contain these compounds. Exemplary nitrogen sources include ammonia gas or ammonia salts, such as NH 4 Cl or (NH 4 ) 2 SO 4 , NH 4 OH, nitrates, urea, amino acids or complex nitrogen sources like corn steep liquor, soy bean flour, soy bean protein, yeast extract, meat extract and others.  
      Inorganic salt compounds which may be included in the media include the chloride-, phosphorous- or sulfate-salts of calcium, magnesium, sodium, cobalt, molybdenum, potassium, manganese, zinc, copper and iron. Chelating compounds can be added to the medium to keep the metal ions in solution. Particularly useful chelating compounds include dihydroxyphenols, like catechol or protocatechuate, or organic acids, such as citric acid. It is typical for the media to also contain other growth factors, such as vitamins or growth promoters, examples of which include biotin, riboflavin, thiamin, folic acid, nicotinic acid, pantothenate and pyridoxin. Growth factors and salts frequently originate from complex media components such as yeast extract, molasses, corn steep liquor and others. The exact composition of the media compounds depends strongly on the immediate experiment and is individually decided for each specific case. Information about media optimization is available in the textbook “Applied Microbiol. Physiology, A Practical Approach (eds. P. M. Rhodes, P. F. Stanbury, IRL Press (1997) pp. 53-73, ISBN 0 19 963577 3). It is also possible to select growth media from commercial suppliers, like standard 1 (Merck) or BHI (grain heart infusion, DIFCO) or others.  
      All medium components are sterilized, either by heat (20 minutes at 1.5 bar and 121° C.) or by sterile filtration. The components can either be sterilized together or, if necessary, separately. All media components can be present at the beginning of growth, or they can optionally be added continuously or batchwise.  
      Culture conditions are defined separately for each experiment. The temperature should be in a range between 15° C. and 45° C. The temperature can be kept constant or can be altered during the experiment. The pH of the medium should be in the range of 5 to 8.5, preferably around 7.0, and can be maintained by the addition of buffers to the media. An exemplary buffer for this purpose is a potassium phosphate buffer. Synthetic buffers such as MOPS, HEPES, ACES and others can alternatively or simultaneously be used. It is also possible to maintain a constant culture pH through the addition of NaOH or NH 4 OH during growth. If complex medium components such as yeast extract are utilized, the necessity for additional buffers may be reduced, due to the fact that many complex compounds have high buffer capacities. If a fermentor is utilized for culturing the micro-organisms, the pH can also be controlled using gaseous ammonia.  
      The incubation time is usually in a range from several hours to several days. This time is selected in order to permit the maximal amount of product to accumulate in the broth. The disclosed growth experiments can be carried out in a variety of vessels, such as microtiter plates, glass tubes, glass flasks or glass or metal fermentors of different sizes. For screening a large number of clones, the microorganisms should be cultured in microtiter plates, glass tubes or shake flasks, either with or without baffles. Preferably 100 ml shake flasks are used, filled with 10% (by volume) of the required growth medium. The flasks should be shaken on a rotary shaker (amplitude 25 mm) using a speed-range of 100-300 rpm. Evaporation losses can be diminished by the maintenance of a humid atmosphere; alternatively, a mathematical correction for evaporation losses should be performed.  
      If genetically modified clones are tested, an unmodified control clone or a control clone containing the basic plasmid without any insert should also be tested. The medium is inoculated to an OD 600  of 0.5-1.5 using cells grown on agar plates, such as CM plates (10 g/l glucose, 2,5 g/l NaCl, 2 g/l urea, 10 g/l polypeptone, 5 g/l yeast extract, 5 g/l meat extract, 22 g/l NaCl, 2 g/l urea, 10 g/l polypeptone, 5 g/l yeast extract, 5 g/l meat extract, 22 g/l agar, pH 6.8 with 2M NaOH) that had been incubated at 30° C. Inoculation of the media is accomplished by either introduction of a saline suspension of  C. glutamicum  cells from CM plates or addition of a liquid preculture of this bacterium.  
     EXAMPLE 8  
     In Vitro Analysis of the Function of Mutant Proteins  
      The determination of activities and kinetic parameters of enzymes is well established in the art. Experiments to determine the activity of any given altered enzyme must be tailored to the specific activity of the wild-type enzyme, which is well within the ability of one of ordinary skill in the art. Overviews about enzymes in general, as well as specific details concerning structure, kinetics, principles, methods, applications and examples for the determination of many enzyme activities may be found, for example, in the following references: Dixon, M., and Webb, E. C., (1979) Enzymes. Longmans: London; Fersht, (1985) Enzyme Structure and Mechanism. Freeman: New York; Walsh, (1979) Enzymatic Reaction Mechanisms. Freeman: San Francisco; Price, N. C., Stevens, L. (1982) Fundamentals of Enzymology. Oxford Univ. Press: Oxford; Boyer, P. D., ed. (1983) The Enzymes, 3 rd  ed. Academic Press: New York; Bisswanger, H., (1994) Enzymkinetik, 2 nd  ed. VCH: Weinheim (ISBN 3527300325); Bergmeyer, H. U., Bergmeyer, J., Graβl, M., eds. (1983-1986) Methods of Enzymatic Analysis, 3 rd  ed., vol. I-XII, Verlag Chemie: Weinheim; and Ullmann&#39;s Encyclopedia of Industrial Chemistry (1987) vol. A9, “Enzymes”. VCH: Weinheim, p. 352-363.  
      The activity of proteins which bind to DNA can be measured by several well-established methods, such as DNA band-shift assays (also called gel retardation assays). The effect of such proteins on the expression of other molecules can be measured using reporter gene assays (such as that described in Kolmar, H. et al. (1995)  EMBO J.  14: 3895-3904 and references cited therein). Reporter gene test systems are well known and established for applications in both pro- and eukaryotic cells, using enzymes such as beta-galactosidase, green fluorescent protein, and several others.  
      The determination of activity of membrane-transport proteins can be performed according to techniques such as those described in Gennis, R. B. (1989) “Pores, Channels and Transporters”, in Biomembranes, Molecular Structure and Function, Springer: Heidelberg, p. 85-137; 199-234; and 270-322.  
     EXAMPLE 9  
     Analysis of Impact of Mutant Protein on the Production of the Desired Product  
      The effect of the genetic modification in  C. glutamicum  on production of a desired compound (such as an amino acid) can be assessed by growing the modified microorganism under suitable conditions (such as those described above) and analyzing the medium and/or the cellular component for increased production of the desired product (i.e., an amino acid). Such analysis techniques are well known to one of ordinary skill in the art, and include spectroscopy, thin layer chromatography, staining methods of various kinds, enzymatic and microbiological methods, and analytical chromatography such as high performance liquid chromatography (see, for example, Ullman, Encyclopedia of Industrial Chemistry, vol. A2, p. 89-90 and p. 443-613, VCH: Weinheim (1985); Fallon, A. et al., (1987) “Applications of HPLC in Biochemistry” in: Laboratory Techniques in Biochemistry and Molecular Biology, vol. 17; Rehm et al. (1993) Biotechnology, vol. 3, Chapter III: “Product recovery and purification”, page 469-714, VCH: Weinheim; Belter, P. A. et al. (1988) Bioseparations: downstream processing for biotechnology, John Wiley and Sons; Kennedy, J. F. and Cabral, J. M. S. (1992) Recovery processes for biological materials, John Wiley and Sons; Shaeiwitz, J. A. and Henry, J. D. (1988) Biochemical separations, in: Ulmann&#39;s Encyclopedia of Industrial Chemistry, vol. B3, Chapter 11, page 1-27, VCH: Weinheim; and Dechow, F. J. (1989) Separation and purification techniques in biotechnology, Noyes Publications.)  
      In addition to the measurement of the final product of fermentation, it is also possible to analyze other components of the metabolic pathways utilized for the production of the desired compound, such as intermediates and side-products, to determine the overall efficiency of production of the compound. Analysis methods include measurements of nutrient levels in the medium (e.g., sugars, hydrocarbons, nitrogen sources, phosphate, and other ions), measurements of biomass composition and growth, analysis of the production of common metabolites of biosynthetic pathways, and measurement of gasses produced during fermentation. Standard methods for these measurements are outlined in Applied Microbial Physiology, A Practical Approach, P. M. Rhodes and P. F. Stanbury, eds., IRL Press, p. 103-129; 131-163; and 165-192 (ISBN: 0199635773) and references cited therein.  
     EXAMPLE 10  
     Purification of the Desired Product from  C. glutamicum  Culture  
      Recovery of the desired product from the  C. glutamicum  cells or supernatant of the above-described culture can be performed by various methods well known in the art. If the desired product is not secreted from the cells, the cells can be harvested from the culture by low-speed centrifugation, the cells can be lysed by standard techniques, such as mechanical force or sonication. The cellular debris is removed by centrifugation, and the supernatant fraction containing the soluble proteins is retained for further purification of the desired compound. If the product is secreted from the  C. glutamicum  cells, then the cells are removed from the culture by low-speed centrifugation, and the supernate fraction is retained for further purification.  
      The supernatant fraction from either purification method is subjected to chromatography with a suitable resin, in which the desired molecule is either retained on a chromatography resin while many of the impurities in the sample are not, or where the impurities are retained by the resin while the sample is not. Such chromatography steps may be repeated as necessary, using the same or different chromatography resins. One of ordinary skill in the art would be well-versed in the selection of appropriate chromatography resins and in their most efficacious application for a particular molecule to be purified. The purified product may be concentrated by filtration or ultrafiltration, and stored at a temperature at which the stability of the product is maximized.  
      There are a wide array of purification methods known to the art and the preceding method of purification is not meant to be limiting. Such purification techniques are described, for example, in Bailey, J. E. &amp; Ollis, D. F. Biochemical Engineering Fundamentals, McGraw-Hill: New York (1986).  
      The identity and purity of the isolated compounds may be assessed by techniques standard in the art. These include high-performance liquid chromatography (HPLC), spectroscopic methods, staining methods, thin layer chromatography, NIRS, enzymatic assay, or microbiologically. Such analysis methods are reviewed in: Patek et al. (1994)  Appl. Environ. Microbiol.  60: 133-140; Malakhova et al. (1996)  Biotekhnologiya  11: 27-32; and Schmidt et al. (1998)  Bioprocess Engineer.  19: 67-70. Ulmann&#39;s Encyclopedia of Industrial Chemistry, (1996) vol. A27, VCH: Weinheim, p. 89-90, p. 521-540, p. 540-547, p. 559-566, 575-581 and p. 581-587; Michal, G. (1999) Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology, John Wiley and Sons; Fallon, A. et al. (1987) Applications of HPLC in Biochemistry in: Laboratory Techniques in Biochemistry and Molecular Biology, vol. 17.  
     EXAMPLE 11  
     Analysis of the Gene Sequences of the Invention  
      The comparison of sequences and determination of percent homology between two sequences are art-known techniques, and can be accomplished using a mathematical algorithm, such as the algorithm of Karlin and Altschul (1990)  Proc. Natl. Acad. Sci. USA  87:2264-68, modified as in Karlin and Altschul (1993)  Proc. Natl. Acad. Sci . USA 90:5873-77. Such an algorithm is incorporated into the NBLAST and XBLAST programs (version 2.0) of Altschul, et al. (1990)  J. Mol. Biol.  215:403-10. BLAST nucleotide searches can be performed with the NBLAST program, score=100, wordlength=12 to obtain nucleotide sequences homologous to MP nucleic acid molecules of the invention. BLAST protein searches can be performed with the XBLAST program, score=50, wordlength=3 to obtain amino acid sequences homologous to MP protein molecules of the invention. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized as described in Altschul et al., (1997)  Nucleic Acids Res.  25(17):3389-3402. When utilizing BLAST and Gapped BLAST programs, one of ordinary skill in the art will know how to optimize the parameters of the program (e.g., XBLAST and NBLAST) for the specific sequence being analyzed.  
      Another example of a mathematical algorithm utilized for the comparison of sequences is the algorithm of Meyers and Miller ((1988)  Comput. Appl. Biosci.  4: 11-17). Such an algorithm is incorporated into the ALIGN program (version 2.0) which is part of the GCG sequence alignment software package. When utilizing the ALIGN program for comparing amino acid sequences, a PAM120 weight residue table, a gap length penalty of 12, and a gap penalty of 4 can be used. Additional algorithms for sequence analysis are known in the art, and include ADVANCE and ADAM. described in Torelli and Robotti (1994)  Comput. Appl. Biosci.  10:3-5; and FASTA, described in Pearson and Lipman (1988)  P.N.A.S.  85:2444-8.  
      The percent homology between two amino acid sequences can also be accomplished using the GAP program in the GCG software package (available at http://www.gcg.com), using either a Blosum 62 matrix or a PAM250 matrix, and a gap weight of 12, 10, 8, 6, or 4 and a length weight of 2, 3, or 4. The percent homology between two nucleic acid sequences can be accomplished using the GAP program in the GCG software package, using standard parameters, such as a gap weight of 50 and a length weight of 3.  
      A comparative analysis of the gene sequences of the invention with those present in Genbank has been performed using techniques known in the art (see, e.g., Bexevanis and Ouellette, eds. (1998) Bioinformatics: A Practical Guide to the Analysis of Genes and Proteins. John Wiley and Sons: New York). The gene sequences of the invention were compared to genes present in Genbank in a three-step process. In a first step, a BLASTN analysis (e.g., a local alignment analysis) was performed for each of the sequences of the invention against the nucleotide sequences present in Genbank, and the top 500 hits were retained for further analysis. A subsequent FASTA search (e.g., a combined local and global alignment analysis, in which limited regions of the sequences are aligned) was performed on these 500 hits. Each gene sequence of the invention was subsequently globally aligned to each of the top three FASTA hits, using the GAP program in the GCG software package (using standard parameters). In order to obtain correct results, the length of the sequences extracted from Genbank were adjusted to the length of the query sequences by methods well-known in the art. The results of this analysis are set forth in Table 4. The resulting data is identical to that which would have been obtained had a GAP (global) analysis alone been performed on each of the genes of the invention in comparison with each of the references in Genbank, but required significantly reduced computational time as compared to such a database-wide GAP (global) analysis. Sequences of the invention for which no alignments above the cutoff values were obtained are indicated on Table 4 by the absence of alignment information. It will further be understood by one of ordinary skill in the art that the GAP alignment homology percentages set forth in Table 4 under the heading “% homology (GAP)” are listed in the European numerical format, wherein a ‘,’ represents a decimal point. For example, a value of “40,345” in this column represents “40.345%”.  
     EXAMPLE 12  
     Construction and Operation of DNA Microarrays  
      The sequences of the invention may additionally be used in the construction and application of DNA microarrays (the design, methodology, and uses of DNA arrays are well known in the art, and are described, for example, in Schena, M. et al. (1995)  Science  270: 467-470; Wodicka, L. et al. (1997)  Nature Biotechnology  15: 1359-1367; DeSaizieu, A. et al. (1998)  Nature Biotechnology  16: 45-48; and DeRisi, J. L. et al. (1997)  Science  278: 680-686).  
      DNA microarrays are solid or flexible supports consisting of nitrocellulose, nylon, glass, silicone, or other materials. Nucleic acid molecules may be attached to the surface in an ordered manner. After appropriate labeling, other nucleic acids or nucleic acid mixtures can be hybridized to the immobilized nucleic acid molecules, and the label may be used to monitor and measure the individual signal intensities of the hybridized molecules at defined regions. This methodology allows the simultaneous quantification of the relative or absolute amount of all or selected nucleic acids in the applied nucleic acid sample or mixture. DNA microarrays, therefore, permit an analysis of the expression of multiple (as many as 6800 or more) nucleic acids in parallel (see, e.g., Schena, M. (1996)  BioEssays  18(5): 427-431).  
      The sequences of the invention may be used to design oligonucleotide primers which are able to amplify defined regions of one or more  C. glutamicum  genes by a nucleic acid amplification reaction such as the polymerase chain reaction. The choice and design of the 5′ or 3′ oligonucleotide primers or of appropriate linkers allows the covalent attachment of the resulting PCR products to the surface of a support medium described above (and also described, for example, Schena, M. et al. (1995)  Science  270: 467-470).  
      Nucleic acid microarrays may also be constructed by in situ oligonucleotide synthesis as described by Wodicka, L. et al. (1997)  Nature Biotechnology  15: 1359-1367. By photolithographic methods, precisely defined regions of the matrix are exposed to light. Protective groups which are photolabile are thereby activated and undergo nucleotide addition, whereas regions that are masked from light do not undergo any modification. Subsequent cycles of protection and light activation permit the synthesis of different oligonucleotides at defined positions. Small, defined regions of the genes of the invention may be synthesized on microarrays by solid phase oligonucleotide synthesis.  
      The nucleic acid molecules of the invention present in a sample or mixture of nucleotides may be hybridized to the microarrays. These nucleic acid molecules can be labeled according to standard methods. In brief, nucleic acid molecules (e.g., mRNA molecules or DNA molecules) are labeled by the incorporation of isotopically or fluorescently labeled nucleotides, e.g., during reverse transcription or DNA synthesis. Hybridization of labeled nucleic acids to microarrays is described (e.g., in Schena, M. et al. (1995) supra; Wodicka, L. et al. (1997), supra; and DeSaizieu A. et al. (1998), supra). The detection and quantification of the hybridized molecule are tailored to the specific incorporated label. Radioactive labels can be detected, for example, as described in Schena, M. et al. (1995) supra) and fluorescent labels may be detected, for example, by the method of Shalon et al. (1996)  Genome Research  6: 639-645).  
      The application of the sequences of the invention to DNA microarray technology, as described above, permits comparative analyses of different strains of  C. glutamicum  or other  Corynebacteria . For example, studies of inter-strain variations based on individual transcript profiles and the identification of genes that are important for specific and/or desired strain properties such as pathogenicity, productivity and stress tolerance are facilitated by nucleic acid array methodologies. Also, comparisons of the profile of expression of genes of the invention during the course of a fermentation reaction are possible using nucleic acid array technology.  
     EXAMPLE 13  
     Analysis of the Dynamics of Cellular Protein Populations  
      (Proteomics)  
      The genes, compositions, and methods of the invention may be applied to study the interactions and dynamics of populations of proteins, termed ‘proteomics’. Protein populations of interest include, but are not limited to, the total protein population of  C. glutamicum  (e.g., in comparison with the protein populations of other organisms), those proteins which are active under specific environmental or metabolic conditions (e.g., during fermentation, at high or low temperature, or at high or low pH), or those proteins which are active during specific phases of growth and development.  
      Protein populations can be analyzed by various well-known techniques, such as gel electrophoresis. Cellular proteins may be obtained, for example, by lysis or extraction, and may be separated from one another using a variety of electrophoretic techniques. Sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) separates proteins largely on the basis of their molecular weight. Isoelectric focusing polyacrylamide gel electrophoresis (IEF-PAGE) separates proteins by their isoelectric point (which reflects not only the amino acid sequence but also posttranslational modifications of the protein). Another, more preferred method of protein analysis is the consecutive combination of both IEF-PAGE and SDS-PAGE, known as 2-D-gel electrophoresis (described, for example, in Hermann et al. (1998) Electrophoresis 19: 3217-3221; Fountoulakis et al. (1998)  Electrophoresis  19: 1193-1202; Langen et al. (1997)  Electrophoresis  18: 1184-1192; Antelmann et al. (1997)  Electrophoresis  18: 1451-1463). Other separation techniques may also be utilized for protein separation, such as capillary gel electrophoresis; such techniques are well known in the art.  
      Proteins separated by these methodologies can be visualized by standard techniques, such as by staining or labeling. Suitable stains are known in the art, and include Coomassie Brilliant Blue, silver stain, or fluorescent dyes such as Sypro Ruby (Molecular Probes). The inclusion of radioactively labeled amino acids or other protein precursors (e.g.,  35 S-methionine,  35 S-cysteine,  14 C-labelled amino acids,  15 N-amino acids,  15 NO 3  or  15 NH 4   +  or  13 C-labelled amino acids) in the medium of  C. glutamicum  permits the labeling of proteins from these cells prior to their separation. Similarly, fluorescent labels may be employed. These labeled proteins can be extracted, isolated and separated according to the previously described techniques.  
      Proteins visualized by these techniques can be further analyzed by measuring the amount of dye or label used. The amount of a given protein can be determined quantitatively using, for example, optical methods and can be compared to the amount of other proteins in the same gel or in other gels. Comparisons of proteins on gels can be made, for example, by optical comparison, by spectroscopy, by image scanning and analysis of gels, or through the use of photographic films and screens. Such techniques are well-known in the art.  
      To determine the identity of any given protein, direct sequencing or other standard techniques may be employed. For example, N- and/or C-terminal amino acid sequencing (such as Edman degradation) may be used, as may mass spectrometry (in particular MALDI or ESI techniques (see, e.g., Langen et al. (1997)  Electrophoresis  18: 1184-1192)). The protein sequences provided herein can be used for the identification of  C. glutamicum  proteins by these techniques.  
      The information obtained by these methods can be used to compare patterns of protein presence, activity, or modification between different samples from various biological conditions (e.g., different organisms, time points of fermentation, media conditions, or different biotopes, among others). Data obtained from such experiments alone, or in combination with other techniques, can be used for various applications, such as to compare the behavior of various organisms in a given (e.g., metabolic) situation, to increase the productivity of strains which produce fine chemicals or to increase the efficiency of the production of fine chemicals.  
      Equivalents  
      Those of ordinary skill in the art will recognize, or will be able to ascertain using no more than routine experimentation, many equivalents to the specific embodiments of the invention described herein. Such equivalents are intended to be encompassed by the following claims.  
               TABLE 1                          Included Genes                                             Ami-                               no       Nucleic   Acid       Acid   SEQ       SEQ   ID   Identification       NT   NT       ID NO   NO   Code   Contig.   Start   Stop   Function                         Lysine biosynthesis                                         1   2   RXA02229   GR00653   2793   3617   DIAMINOPIMELATE EPIMERASE (EC 5.1.1.7)       3   4   RXS02970               ACETYLORNITHINE AMINOTRANSFERASE (EC 2.6.1.11)       5   6   F RXA01009   GR00287   4714   5943   ACETYLORNITHINE AMINOTRANSFERASE (EC 2.6.1.11)       7   8   RXC02390               MEMBRANE SPANNING PROTEIN INVOLVED IN LYSINE METABOLISM       9   10   RXC01796               MEMBRANE ASSOCIATED PROTEIN INVOLVED IN LYSINE METABOLISM       11   12   RXC01207               CYTOSOLIC PROTEIN INVOLVED IN METABOLISM OF LYSINE AND                               THREONINE       13   14   RXC00657               TRANSCRIPTIONAL REGULATOR INVOLVED IN LYSINE METABOLISM       15   16   RXC00552               CYTOSOLIC PROTEIN INVOLVED IN LYSINE METABOLISM                 Trehalose                                         17   18   RXN00351   VV0135   37078   38532   ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE                               (UDP-FORMING) 56 KD SUBUNIT (EC 2.4.1.15)       19   20   F RXA00351   GR00066   1486   2931   ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE (UDP-FORMING)                               56 KD SUBUNIT (EC 2.4.1.15)       21   22   RXA00873   GR00241   3   758   trehalose synthase (EC 2.4.1.—)       23   24   RXA00891   GR00243   1005   4   trehalose synthase (EC 2.4.1.—)                 Lysine biosynthesis                                         25   26   RXA00534   GR00137   4758   3496   ASPARTOKINASE ALPHA AND BETA SUBUNITS (EC 2.7.2.4)       27   28   RXA00533   GR00137   3469   2438   ASPARTATE-SEMIALDEHYDE DEHYDROGENASE (EC 1.2.1.11)       29   30   RXA02843   GR00842   543   4   2,3,4,5-TETRAHYDROPYRIDINE-2-CARBOXYLATE                               N-SUCCINYLTRANSFERASE (EC 2.3.1.117)       31   32   RXA02022   GR00613   2063   3169   SUCCINYL-DIAMINOPIMELATE DESUCCINYLASE (EC 3.5.1.18)       33   34   RXA00044   GR00007   3458   4393   DIHYDRODIPICOLINATE SYNTHASE (EC 4.2.1.52)       35   36   RXA00863   GR00236   896   1639   DIHYDRODIPICOLINATE REDUCTASE (EC 1.3.1.26)       37   38   RXA00864   GR00236   1694   2443   probable 2,3-dihydrodipicolinate N-C6-lyase (cyclizing) (EC 4.3.3.—) -                                 Corynebacterium glutamicum         39   40   RXA02843   GR00842   543   4   2,3,4,5-TETRAHYDROPYRIDINE-2-CARBOXYLATE                               N-SUCCINYLTRANSFERASE (EC 2.3.1.117)       41   42   RXN00355   VV0135   31980   30961   MESO-DIAMINOPIMELATE D-DEHYDROGENASE       43   44   F RXA00352   GR00068   861   4   MESO-DIAMINOPIMELATE D-DEHYDROGENASE (EC 1.4.1.16)       45   46   RXA00972   GR00274   3   1379   DIAMINOPIMELATE DECARBOXYLASE (EC 4.1.1.20)       47   48   RXA02653   GR00752   5237   7234   DIAMINOPIMELATE DECARBOXYLASE (EC 4.1.1.20)       49   50   RXA01393   GR00408   4249   3380   LYSINE EXPORT REGULATOR PROTEIN       51   52   RXA00241   GR00036   5443   6945   L-LYSINE TRANSPORT PROTEIN       53   54   RXA01394   GR00408   4320   5018   LYSINE EXPORTER PROTEIN       55   56   RXA00865   GR00236   2647   3549   DIHYDRODIPICOLINATE SYNTHASE (EC 4.2.1.52)       57   58   RXS02021               2,3,4,5-TETRAHYDROPYRIDINE-2-CARBOXYLATE                               N-SUCCINYLTRANSFERASE (EC 2.3.1.117)       59   60   RXS02157               ACETYLORNITHINE AMINOTRANSFERASE (EC 2.6.1.11)       61   62   RXC00733               ABC TRANSPORTER ATP-BINDING PROTEIN INVOLVED IN LYSINE                               METABOLISM       63   64   RXC00861               PROTEIN INVOLVED IN LYSINE METABOLISM       65   66   RXC00866               ZN-DEPENDENT HYDROLASE INVOLVED IN LYSINE METABOLISM       67   68   RXC02095               ABC TRANSPORTER ATP-BINDING PROTEIN INVOLVED IN LYSINE                               METABOLISM       69   70   RXC03185               PROTEIN INVOLVED IN LYSINE METABOLISM                 Glutamate and glutamine metabolism                                         71   72   RXN00367   VV0196   9744   14273   GLUTAMATE SYNTHASE [NADH] PRECURSOR (EC 1.4.1.14)       73   74   F RXA00007   GR00001   7107   8912   GLUTAMATE SYNTHASE (NADPH) LARGE CHAIN PRECURSOR (EC 1.4.1.13)       75   76   F RXA00364   GR00074   1296   4   GLUTAMATE SYNTHASE (NADPH) LARGE CHAIN PRECURSOR (EC 1.4.1.13)       77   78   F RXA00367   GR00075   1806   964   GLUTAMATE SYNTHASE (NADPH) LARGE CHAIN PRECURSOR (EC 1.4.1.13)       79   80   RXN00076   VV0154   2752   4122   GLUTAMATE SYNTHASE (NADPH) SMALL CHAIN (EC 1.4.1.13)       81   82   F RXA00075   GR00012   2757   3419   GLUTAMATE SYNTHASE (NADPH) SMALL CHAIN (EC 1.4.1.13)       83   84   RXN00198   VV0181   7916   7368   GLUTAMATE SYNTHASE (NADPH) SMALL CHAIN (EC 1.4.1.13)       85   86   F RXA00198   GR00031   2   283   GLUTAMATE SYNTHASE (NADPH) SMALL CHAIN (EC 1.4.1.13)       87   88   RXN00365   VV0196   14607   15233   GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN (EC 1.4.1.13)       89   90   F RXA00365   GR00075   630   4   GLUTAMATE SYNTHASE (NADPH) SMALL CHAIN (EC 1.4.1.13)       91   92   RXA00366   GR00075   961   605   GLUTAMATE SYNTHASE (NADPH) SMALL CHAIN (EC 1.4.1.13)       93   94   RXA02072   GR00628   1259   2599   NADP-SPECIFIC GLUTAMATE DEHYDROGENASE (EC 1.4.1.4)       95   96   RXA00323   GR00057   3855   5192   GLUTAMINE SYNTHETASE (EC 6.3.1.2)       97   98   RXA00335   GR00057   19180   17750   GLUTAMINE SYNTHETASE (EC 6.3.1.2)       99   100   RXA00324   GR00057   5262   8396   GLUTAMATE-AMMONIA-LIGASE ADENYLYLTRANSFERASE (EC 2.7.7.42)       101   102   RXN03176   VV0332   2   862   GLUTAMINASE (EC 3.5.1.2)       103   104   F RXA02879   GR10017   2   862   GLUTAMINASE (EC 3.5.1.2)       105   106   RXA00278   GR00043   2612   1581   GLUTAMINE-BINDING PROTEIN PRECURSOR       107   108   RXA00727   GR00193   614   1525   GLUTAMINE-BINDING PERIPLASMIC PROTEIN PRECURSOR                 Alanine and Aspartate and Asparagine metabolism                                         109   110   RXA02139   GR00639   6739   4901   ASPARAGINE SYNTHETASE (GLUTAMINE-HYDROLYZING) (EC 6.3.5.4)       111   112   RXN00116   VV0100   26974   25814   ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)       113   114   F RXA00116   GR00018   510   4   ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)       115   116   RXN00618   VV0135   10288   9182   ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)       117   118   F RXA00618   GR00163   213   746   ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)       119   120   F RXA00627   GR00164   854   1138   ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)       121   122   RXA02550   GR00729   1585   275   ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)       123   124   RXA02193   GR00645   1942   365   ASPARTATE AMMONIA-LYASE (EC 4.3.1.1)       125   126   RXA02432   GR00708   2669   1695   L-ASPARAGINASE (EC 3.5.1.1)       127   128   RXN03003   VV0138   680   6   ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)       129   130   RXN00508   VV0086   4701   5783   ALANINE RACEMASE (EC 5.1.1.1)       131   132   RXN00636   VV0135   20972   19944   ALANINE RACEMASE, BIOSYNTHETIC (EC 5.1.1.1)                 beta-Alanine metabolism                                         133   134   RXA02536   GR00726   8581   7826   BETA-UREIDOPROPIONASE (EC 3.5.1.6)       135   136   RXS00870               METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE (ACYLATING)                               (EC 1.2.1.27)       137   138   RXS02299               ASPARTATE 1-DECARBOXYLASE PRECURSOR (EC 4.1.1.11)                 Glycine and serine metabolism                                         139   140   RXA01561   GR00435   1113   2042   L-SERINE DEHYDRATASE (EC 4.2.1.13)       141   142   RXA01850   GR00525   481   1827   L-SERINE DEHYDRATASE (EC 4.2.1.13)       143   144   RXA00580   GR00156   7343   6042   SERINE HYDROXYMETHYLTRANSFERASE (EC 2.1.2.1)       145   146   RXA01821   GR00515   10253   9876   SARCOSINE OXIDASE (EC 1.5.3.1)       147   148   RXN02263   VV0202   11783   12160   SARCOSINE OXIDASE (EC 1.5.3.1)       149   150   F RXA02263   GR00654   33454   33813   SARCOSINE OXIDASE (EC 1.5.3.1)       151   152   RXA02176   GR00641   11454   12581   PHOSPHOSERINE AMINOTRANSFERASE (EC 2.6.1.52)       153   154   RXN02758   GR00766   5082   4648   PHOSPHOSERINE PHOSPHATASE (EC 3.1.3.3)       155   156   F RXA02479   GR00717   393   4   PHOSPHOSERINE PHOSPHATASE (EC 3.1.3.3)       157   158   F RXA02758   GR00766   5082   4648   PHOSPHOSERINE PHOSPHATASE (EC 3.1.3.3)       159   160   F RXA02759   GR00766   5330   5220   PHOSPHOSERINE PHOSPHATASE (EC 3.1.3.3)       161   162   RXA02501   GR00720   15041   13977   PHOSPHOSERINE PHOSPHATASE (EC 3.1.3.3)       163   164   RXN03105   VV0074   15857   15423   SARCOSINE OXIDASE (EC 1.5.3.1)       165   166   RXS01130               D-3-PHOSPHOGLYCERATE DEHYDROGENASE (EC 1.1.1.95)       167   168   RXS03112               D-3-PHOSPHOGLYCERATE DEHYDROGENASE (EC 1.1.1.95)                 Threonine metabolism                                         169   170   RXN00969   VV0149   12053   13387   HOMOSERINE DEHYDROGENASE (EC 1.1.1.3)       171   172   F RXA00974   GR00274   2623   3015   HOMOSERINE DEHYDROGENASE (EC 1.1.1.3)       173   174   RXA00970   GR00273   161   1087   HOMOSERINE KINASE (EC 2.7.1.39)       175   176   RXA00330   GR00057   12968   14410   THREONINE SYNTHASE (EC 4.2.99.2)       177   178   RXN00403   VV0086   70041   68911   HOMOSERINE O-ACETYLTRANSFERASE       179   180   F RXA00403   GR00088   723   1832   HOMOSERINE O-ACETYLTRANSFERASE (EC 2.3.1.11)       181   182   RXC01207               CYTOSOLIC PROTEIN INVOLVED IN METABOLISM OF LYSINE AND                               THREONINE       183   184   RXC00152               MEMBRANE ASSOCIATED PROTEIN INVOLVED IN                               THREONINE METABOLISM                 Metabolism of methionine and S-adenosyl methionine                                         185   186   RXA00115   GR00017   5359   4313   HOMOSERINE O-ACETYLTRANSFERASE (EC 2.3.1.31)       187   188   RXN00403   VV0086   70041   68911   HOMOSERINE O-ACETYLTRANSFERASE       189   190   F RXA00403   GR00088   723   1832   HOMOSERINE O-ACETYLTRANSFERASE (EC 2.3.1.11)       191   192   RXS03158               CYSTATHIONINE GAMMA-SYNTHASE (EC 4.2.99.9)       193   194   F RXA00254   GR00038   2404   1811   CYSTATHIONINE GAMMA-SYNTHASE (EC 4.2.99.9)       195   196   RXA02532   GR00726   3085   2039   CYSTATHIONINE GAMMA-SYNTHASE (EC 4.2.99.9)       197   198   RXS03159               CYSTATHIONINE GAMMA-SYNTHASE (EC 4.2.99.9)       199   200   F RXA02768   GR00770   1919   2521   CYSTATHIONINE GAMMA-SYNTHASE (EC 4.2.99.9)       201   202   RXA00216   GR00032   16286   15297   5-methyltetrahydrofolate-homocysteine methyltransferase (methionine synthetase)       203   204   RXN00402   VV0086   70787   70188   O-ACETYLHOMOSERINE SULFHYDRYLASE                               (EC 4.2.99.10)/O-ACETYLSERINE SULFHYDRYLASE (EC 4.2.99.8)       205   206   F RXA00402   GR00088   1   576   O-ACETYLHOMOSERINE SULFHYDRYLASE                               (EC 4.2.99.10)/O-ACETYLSERINE SULFHYDRYLASE (EC 4.2.99.8)       207   208   RXA00405   GR00089   3289   3801   O-ACETYLHOMOSERINE SULFHYDRYLASE (EC 4.2.99.10)/                               O-ACETYLSERINE SULFHYDRYLASE (EC 4.2.99.8)       209   210   RXA02197   GR00645   4552   4025   5-METHYLTETRAHYDROFOLATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.13)       211   212   RXN02198   VV0302   9228   11726   5-METHYLTETRAHYDROFOLATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.13)       213   214   F RXA02198   GR00646   2483   6   5-METHYLTETRAHYDROFOLATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.13)       215   216   RXN03074   VV0042   2238   1741   S-ADENOSYLMETHIONINE:2-DEMETHYLMENAQUINONE                               METHYLTRANSFERASE (EC 2.1.N—.—)       217   218   F RXA02906   GR10044   1142   645   S-ADENOSYLMETHIONINE:2-DEMETHYLMENAQUINONE                               METHYLTRANSFERASE (EC 2.1.—.—)       219   220   RXN00132   VV0124   3612   5045   ADENOSYLHOMOCYSTEINASE (EC 3.3.1.1)       221   222   F RXA00132   GR00020   7728   7624   ADENOSYLHOMOCYSTEINASE (EC 3.3.1.1)       223   224   F RXA01371   GR00398   2339   3634   ADENOSYLHOMOCYSTEINASE (EC 3.3.1.1)       225   226   RXN02085               5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.14)       227   228   F RXA02085   GR00629   3496   5295   5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.14)       229   230   F RXA02086   GR00629   5252   5731   5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.14)       231   232   RXN02648               5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.14)       233   234   F RXA02648   GR00751   5254   4730   5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.14)       235   236   F RXA02658   GR00752   14764   15447   5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.14)       237   238   RXC02238               PROTEIN INVOLVED IN METABOLISM OF S-ADENOSYLMETHIONINE,                               PURINES AND PANTOTHENATE       239   240   RXC00128               EXPORTED PROTEIN INVOLVED IN METABOLISM OF PYRIDIMES AND                               ADENOSYLHOMOCYSTEINE                 S-adenosyl methionine (SAM) Biosynthesis                                         241   242   RXA02240   GR00654   7160   8380   S-ADENOSYLMETHIONINE SYNTHETASE (EC 2.5.1.6)                 Cysteine metabolism                                         243   244   RXA00780   GR00206   1689   2234   SERINE ACETYLTRANSFERASE (EC 2.3.1.30)       245   246   RXA00779   GR00206   550   1482   CYSTEINE SYNTHASE (EC 4.2.99.8)       247   248   RXN00402   VV0086   70787   70188   O-ACETYLHOMOSERINE SULFHYDRYLASE                               (EC 4.2.99.10)/O-ACETYLSERINE SULFHYDRYLASE (EC 4.2.99.8)       249   250   F RXA00402   GR00088   1   576   O-ACETYLHOMOSERINE SULFHYDRYLASE (EC 4.2.99.10)/                               O-ACETYLSERINE SULFHYDRYLASE (EC 4.2.99.8)       251   252   RXS00405               O-ACETYLHOMOSERINE SULFHYDRYLASE (EC 4.2.99.10)/                               O-ACETYLSERINE SULFHYDRYLASE (EC 4.2.99.8)       253   254   RXC00164               ABC TRANSPORTER ATP-BINDING PROTEIN INVOLVED IN CYSTEINE                               METABOLISM       255   256   RXC01191               ABC TRANSPORTER ATP-BINDING PROTEIN INVOLVED IN CYSTEINE                               METABOLISM                 Valine, leucine and isoleucine                                         257   258   RXA02646   GR00751   3856   2588   THREONINE DEHYDRATASE BIOSYNTHETIC (EC 4.2.1.16)       259   260   RXA00766   GR00204   5091   4249   BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE (EC 2.6.1.42)       261   262   RXN01690   VV0246   1296   196   BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE (EC 2.6.1.42)       263   264   F RXA01690   GR00473   1248   196   BRANCHED-CHAIN AMINO ACID AMINOTRANSFERASE (EC 2.6.1.42)       265   266   RXN01026   VV0143   9171   7513   3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33)       267   268   F RXA01026   GR00294   1   1602   3-ISOPROPYLMALATE DEHYDRATASE LARGE SUBUNIT (EC 4.2.1.33)       269   270   RXN01127   VV0157   4491   3472   3-ISOPROPYLMALATE DEHYDROGENASE (EC 1.1.1.85)       271   272   F RXA01132   GR00315   1349   1651   3-ISOPROPYLMALATE DEHYDROGENASE (EC 1.1.1.85)       273   274   RXN00536   VV0219   6128   7498   2-ISOPROPYLMALATE SYNTHASE (EC 4.1.3.12)       275   276   F RXA00536   GR00137   6128   7360   2-ISOPROPYLMALATE SYNTHASE (EC 4.1.3.1)       277   278   RXN02965   VV0143   7711   7121   3-ISOPROPYLMALATE DEHYDRATASE SMALL SUBUNIT (EC 4.2.1.33)       279   280   RXN01929   VV0127   47590   48402   3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE                               (EC 2.1.2.11)/DECARBOXYLASE (EC 4.1.1.44)       281   282   F RXA01929   GR00555   2766   1960   3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE                               (EC 2.1.2.11)       283   284   RXN01420   VV0122   15584   14643   4″-MYCAROSYL ISOVALERYL-COA TRANSFERASE (EC 2.—.—.—)       285   286   RXS01145               KETOL-ACID REDUCTOISOMERASE (EC 1.1.1.86)       287   288   F RXA01145   GR00321   1075   1530   KETOL-ACID REDUCTOISOMERASE (EC 1.1.1.86)                 Arginine and proline metabolism       Enzymes of proline biosynthesis:                                         289   290   RXA02375   GR00689   1449   223   GLUTAMATE 5-KINASE (EC 2.7.2.11)       291   292   RXN02382   VV0213   5162   3867   GAMMA-GLUTAMYL PHOSPHATE REDUCTASE (GPR) (EC 1.2.1.41)       293   294   F RXA02378   GR00690   624   16   GAMMA-GLUTAMYL PHOSPHATE REDUCTASE (GPR) (EC 1.2.1.41)       295   296   F RXA02382   GR00691   2493   1894   GAMMA-GLUTAMYL PHOSPHATE REDUCTASE (GPR) (EC 1.2.1.41)       297   298   RXA02499   GR00720   11883   12692   PYRROLINE-5-CARBOXYLATE REDUCTASE (EC 1.5.1.2)       299   300   RXS02157               ACETYLORNITHINE AMINOTRANSFERASE (EC 2.6.1.11)       301   302   RXS02262               ORNITHINE CYCLODEAMINASE (EC 4.3.1.12)       303   304   RXS02970               ACETYLORNITHINE AMINOTRANSFERASE (EC 2.6.1.11)       305   306   F RXA01009   GR00287   4714   5943   ACETYLORNITHINE AMINOTRANSFERASE (EC 2.6.1.11)                 Enzymes of proline degradation:                                         307   308   RXN00023   VV0127   68158   64703   PROLINE DEHYDROGENASE (EC 1.5.99.8)/DELTA-1-PYRROLINE-5-                               CARBOXYLATE DEHYDROGENASE (EC 1.5.1.12)       309   310   F RXA00023   GR00003   2   454   PROLINE DEHYDROGENASE (EC 1.5.99.8)/DELTA-1-PYRROLINE-5-                               CARBOXYLATE DEHYDROGENASE (EC 1.5.1.12)       311   312   F RXA02284   GR00660   3028   5   PROLINE DEHYDROGENASE (EC 1.5.99.8)/DELTA-1-PYRROLINE-5-                               CARBOXYLATE DEHYDROGENASE (EC 1.5.1.12)       313   314   RXC02498               PROTEIN INVOLVED IN PROLINE METABOLISM                 Synthesis of 3-Hydoxy-proline:                                         315   316   RXA01491   GR00423   5337   4687   DNA FOR L-PROLINE 3-HYDROXYLASE, COMPLETE CDS                 Enzymes of ornithine, arginine and spermidine metabolism:                                         317   318   RXA02155   GR00640   1913   3076   GLUTAMATE N-ACETYLTRANSFERASE (EC 2.3.1.35)/AMINO-ACID                               ACETYLTRANSFERASE (EC 2.3.1.1)       319   320   RXA02156   GR00640   3125   4075   ACETYLGLUTAMATE KINASE (EC 2.7.2.8)       321   322   RXN02153   VV0122   14106   13327   N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE (EC 1.2.1.38)       323   324   F RXA02153   GR00640   757   1536   N-ACETYLGLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE       325   326   RXA02154   GR00640   1536   1826   N-ACETYLGLUTAMATE-5-SEMIALDEHYDE DEHYDROGENASE       327   328   RXA02157   GR00640   4079   5251   ACETYLORNITHINE AMINOTRANSFERASE (EC 2.6.1.11)       329   330   RXS02970               ACETYLORNITHINE AMINOTRANSFERASE (EC 2.6.1.11)       331   332   F RXA01009   GR00287   4714   5943   ACETYLORNITHINE AMINOTRANSFERASE (EC 2.6.1.11)       333   334   RXA02158   GR00640   5268   6224   ORNITHINE CARBAMOYLTRANSFERASE (EC 2.1.3.3)       335   336   RXA02160   GR00640   6914   8116   ARGININOSUCCINATE SYNTHASE (EC 6.3.4.5)       337   338   RXN02162   VV0122   6683   5253   ARGININOSUCCINATE LYASE (EC 4.3.2.1)       339   340   F RXA02161   GR00640   8180   8962   ARGININOSUCCINATE LYASE (EC 4.3.2.1)       341   342   F RXA02162   GR00640   8949   9611   ARGININOSUCCINATE LYASE (EC 4.3.2.1)       343   344   RXA02262   GR00654   32291   33436   ORNITHINE CYCLODEAMINASE (EC 4.3.1.12)       345   346   RXA00219   GR00032   19289   20230   SPERMIDINE SYNTHASE (EC 2.5.1.16)       347   348   RXA01508   GR00424   12652   14190   SPERMIDINE SYNTHASE (EC 2.5.1.16)       349   350   RXA01757   GR00498   2942   2142   PUTRESCINE OXIDASE (EC 1.4.3.10)       351   352   RXA02159   GR00640   6231   6743   ARGININE HYDROXIMATE RESISTANCE PROTEIN       353   354   RXN02154   VV0122   13327   13037   N-ACETYL-GAMMA-GLUTAMYL-PHOSPHATE REDUCTASE (EC 1.2.1.38)       355   356   RXS00147               CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN (EC 6.3.5.5)       357   358   RXS00905               N-ACYL-L-AMINO ACID AMIDOHYDROLASE (EC 3.5.1.14)       359   360   RXS00906               N-ACYL-L-AMINO ACID AMIDOHYDROLASE (EC 3.5.1.14)       361   362   RXS00907               N-ACYL-L-AMINO ACID AMIDOHYDROLASE (EC 3.5.1.14)       363   364   RXS02001               N-ACYL-L-AMINO ACID AMIDOHYDROLASE (EC 3.5.1.14)       365   366   RXS02101               N-ACYL-L-AMINO ACID AMIDOHYDROLASE (EC 3.5.1.14)       367   368   RXS02234               CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN (EC 6.3.5.5)       369   370   F RXA02234   GR00654   1   3198   CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN (EC 6.3.5.5)       371   372   RXS02565               N-ACYL-L-AMINO ACID AMIDOHYDROLASE (EC 3.5.1.14)       373   374   RXS02937               N-ACYL-L-AMINO ACID AMIDOHYDROLASE (EC 3.5.1.14)                 Histidine metabolism                                         375   376   RXA02194   GR00645   2897   2055   ATP PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.17)       377   378   RXA02195   GR00645   3186   2917   PHOSPHORIBOSYL-ATP PYROPHOSPHOHYDROLASE (EC 3.6.1.31)       379   380   RXA01097   GR00306   4726   4373   PHOSPHORIBOSYL-AMP CYCLOHYDROLASE (EC 3.5.4.19)       381   382   RXA01100   GR00306   7072   6335   PHOSPHORIBOSYLFORMIMINO-5-AMINOIMIDAZOLE CARBOXAMIDE                               RIBOTIDE ISOMERASE (EC 5.3.1.16)       383   384   RXA01101   GR00306   7726   7094   AMIDOTRANSFERASE HISH (EC 2.4.2.—)       385   386   RXN01657   VV0010   39950   39351   AMIDOTRANSFERASE HISH (EC 2.4.2.—)       387   388   F RXA01657   GR00460   2444   2944   AMIDOTRANSFERASE HISH (EC 2.4.2.—)       389   390   RXA01098   GR00306   5499   4726   HISF PROTEIN       391   392   RXN01104   VV0059   7037   6432   IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (EC 4.2.1.19)       393   394   F RXA01104   GR00306   10927   10322   IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE (EC 4.2.1.19)/                               HISTIDINOL-PHOSPHATASE (EC 3.1.3.15)       395   396   RXN00446   VV0112   24181   23318   HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (EC 2.6.1.9)       397   398   F RXA00446   GR00108   4   525   HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (EC 2.6.1.9)       399   400   RXA01105   GR00306   12044   10947   HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (EC 2.6.1.9)       401   402   RXA01106   GR00306   13378   12053   HISTIDINOL DEHYDROGENASE (EC 1.1.1.23)       403   404   RXC00930               PROTEIN INVOLVED IN HISTIDINE METABOLISM       405   406   RXC01096               PROTEIN INVOLVED IN HISTIDINE METABOLISM       407   408   RXC01656               PROTEIN INVOLVED IN HISTIDINE METABOLISM       409   410   RXC01158               MEMBRANE SPANNING PROTEIN INVOLVED IN HISTIDINE METABOLISM                 Metabolism of aromatic amino acids                                         411   412   RXA02458   GR00712   3056   4345   3-PHOSPHOSHIKIMATE 1-CARBOXYVINYLTRANSFERASE (EC 2.5.1.19)       413   414   RXA02790   GR00777   5806   6948   4-AMINO-4-DEOXYCHORISMATE LYASE (EC 4.—.—.—)       415   416   RXN00954   VV0247   3197   2577   ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.18)       417   418   F RXA00954   GR00263   3   590   ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.18)       419   420   RXN00957   VV0208   1211   2764   ANTHRANILATE SYNTHASE COMPONENT I (EC 4.1.3.27)       421   422   F RXA00957   GR00264   3   1130   ANTHRANILATE SYNTHASE COMPONENT I (EC 4.1.3.27)       423   424   RXA02687   GR00754   11306   12250   CHORISMATE MUTASE (EC 5.4.99.5)/PREPHENATE DEHYDRATASE (EC                               4.2.1.51)       425   426   RXN01698   VV0134   11507   12736   CHORISMATE SYNTHASE (EC 4.6.1.4)       427   428   F RXA01698   GR00477   2   991   CHORISMATE SYNTHASE (EC 4.6.1.4)       429   430   RXA01095   GR00306   3603   2821   INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE (EC 4.1.1.48)       431   432   RXA00955   GR00263   586   2007   INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE (EC 4.1.1.48)/N-(5′-PHOSPHO-                               RIBOSYL)ANTHRANILATE ISOMERASE (EC 5.3.1.24)       433   434   RXA02814   GR00795   598   128   ISOCHORISMATE MUTASE       435   436   RXA00229   GR00033   1715   936   SHIKIMATE 5-DEHYDROGENASE (EC 1.1.1.25)       437   438   RXA02093   GR00629   12444   13247   SHIKIMATE 5-DEHYDROGENASE (EC 1.1.1.25)       439   440   RXA02791   GR00777   6968   7795   SHIKIMATE 5-DEHYDROGENASE (EC 1.1.1.25)       441   442   RXA01699   GR00477   984   1553   SHIKIMATE KINASE (EC 2.7.1.71)       443   444   RXA00952   GR00262   97   936   TRYPTOPHAN SYNTHASE ALPHA CHAIN (EC 4.2.1.20)       445   446   RXN00956   VV0247   1140   4   TRYPTOPHAN SYNTHASE BETA CHAIN (EC 4.2.1.20)       447   448   F RXA00956   GR00263   2027   3157   TRYPTOPHAN SYNTHASE BETA CHAIN (EC 4.2.1.20)       449   450   RXA00064   GR00010   2499   3776   TYROSINE AMINOTRANSFERASE (EC 2.6.1.5)       451   452   RXN00448   VV0112   33959   32940   PREPHENATE DEHYDROGENASE (EC 1.3.1.12)       453   454   F RXA00448   GR00109   3   668   PREPHENATE DEHYDROGENASE (EC 1.3.1.12)       455   456   F RXA00452   GR00110   854   1099   PREPHENATE DEHYDROGENASE (EC 1.3.1.12)       457   458   RXA00584   GR00156   11384   10260   PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE (EC 4.1.2.15)       459   460   RXA00579   GR00156   5946   4087   PARA-AMINOBENZOATE SYNTHASE COMPONENT I (EC 4.1.3.—)       461   462   RXA00958   GR00264   1130   1753   PARA-AMINOBENZOATE SYNTHASE GLUTAMINE AMIDOTRANSFERASE                               COMPONENT II (EC 4.1.3.—)/ANTHRANILATE SYNTHASE                               COMPONENT II (EC 4.1.3.27)       463   464   RXN03007   VV0208   3410   3778   ANTHRANILATE SYNTHASE COMPONENT II (EC 4.1.3.27)       465   466   RXN02918   VV0086   25447   25887   TRYPTOPHAN SYNTHASE BETA CHAIN (EC 4.2.1.20)       467   468   RXN01116   VV0182   7497   6886   3-OXOADIPATE COA-TRANSFERASE SUBUNIT B (EC 2.8.3.6)       469   470   RXN01115   VV0182   10347   11099   3-OXOADIPATE ENOL-LACTONE HYDROLASE (EC 3.1.1.24)/4-                               CARBOXYMUCONOLACTONE       471   472   RXS00116               ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)       473   474   F RXA00116   GR00018   510   4   ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)       475   476   RXS00391               O-SUCCINYLBENZOIC ACID - COA LIGASE (EC 6.2.1.26)       477   478   RXS00393               1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE                               (EC 2.5.—.—)       479   480   F RXA00393   GR00086   4030   4911   1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE                               (EC 2.5.—.—)       481   482   RXS00446               HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (EC 2.6.1.9)       483   484   F RXA00446   GR00108   4   525   HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (EC 2.6.1.9)       485   486   RXS00618               ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)       487   488   F RXA00618   GR00163   213   746   ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)       489   490   F RXA00627   GR00164   854   1138   ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)       491   492   RXS01105               HISTIDINOL-PHOSPHATE AMINOTRANSFERASE (EC 2.6.1.9)       493   494   RXS02315               2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE                               SYNTHASE/2-OXOGLUTARATE DECARBOXYLASE (EC 4.1.1.71)       495   496   RXS02550               ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)       497   498   RXS02319               NAPHTHOATE SYNTHASE (EC 4.1.3.36)       499   500   RXS02908               O-SUCCINYLBENZOIC ACID - COA LIGASE (EC 6.2.1.26)       501   502   RXS03003               ASPARTATE AMINOTRANSFERASE (EC 2.6.1.1)       503   504   RXS03026               3-DEHYDROQUINATE DEHYDRATASE (EC 4.2.1.10)       505   506   RXS03074               S-ADENOSYLMETHIONINE: 2-DEMETHYLMENAQUINONE                               METHYLTRANSFERASE (EC 2.1.—.—)       507   508   RXC01434               MEMBRANE SPANNING PROTEIN INVOLVED IN METABOLISM                               OF AROMATIC AMINO ACIDS AND RIBOFLAVIN       509   510   RXC02080               MEMBRANE SPANNING PROTEIN INVOLVED IN METABOLISM                               OF AROMATIC AMINO ACIDS       511   512   RXC02789               CYTOSOLIC PROTEIN INVOLVED IN METABOLISM OF AROMATIC AMINO                               ACIDS       513   514   RXC02295               MEMBRANE SPANNING PROTEIN INVOLVED IN METABOLISM OF                               AROMATIC AMINO ACIDS                 Aminobutyrate metabolism                                         515   516   RXN03063   VV0035   666   1697   4-aminobutyrate aminotransferase (EC 2.6.1.19)       517   518   RXN02970   VV0021   4714   6081   ACETYLORNITHINE AMINOTRANSFERASE (EC 2.6.1.11)       519   520   F RXA01009   GR00287   4714   5943   ACETYLORNITHINE AMINOTRANSFERASE (EC 2.6.1.11)                 Vitamins, vitamin-like substances (cofactors), nutraceuticals       Thiamine metabolism                                         521   522   RXA01551   GR00431   2945   4819   THIAMIN BIOSYNTHESIS PROTEIN THIC       523   524   RXA01019   GR00291   6   995   THIAMIN-MONOPHOSPHATE KINASE (EC 2.7.4.16)       525   526   RXA01352   GR00393   609   4   THIAMIN-PHOSPHATE PYROPHOSPHORYLASE (EC 2.5.1.3)       527   528   RXA01381   GR00403   3206   2286   THIF PROTEIN       529   530   RXA01360   GR00394   162   4   THIG PROTEIN       531   532   RXA01361   GR00394   983   378   THIG PROTEIN       533   534   RXA01208   GR00348   229   1032   HYDROXYETHYLTHIAZOLE KINASE (EC 2.7.1.50)       535   536   RXA00838   GR00227   1532   633   APBA PROTEIN       537   538   RXA02400   GR00699   1988   2557   THIAMIN BIOSYNTHESIS PROTEIN X       539   540   RXN01209   VV0270   1019   2446   PHOSPHOMETHYLPYRIMIDINE KINASE (EC 2.7.4.7)       541   542   F RXA01209   GR00348   1019   2446   PHOSPHOMETHYLPYRIMIDINE KINASE (EC 2.7.4.7)       543   544   RXN01413   VV0050   27306   27905   PHOSPHOMETHYLPYRIMIDINE KINASE (EC 2.7.4.7)       545   546   RXN01617   VV0050   22187   22858   PHOSPHOMETHYLPYRIMIDINE KINASE (EC 2.7.4.7)       547   548   F RXA01617   GR00451   2   616   PHOSPHOMETHYLPYRIMIDINE KINASE (EC 2.7.4.7)       549   550   RXS01807               PYRIDOXINE KINASE (EC 2.7.1.35)       551   552   RXC01021               CYTOSOLIC KINASE INVOLVED IN METABOLISM OF SUGARS                               AND THIAMIN                 Riboflavin metabolism                                         553   554   RXN02246   VV0130   4388   5371   diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26)/5-amino-                               6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193)       555   556   F RXA02246   GR00654   14299   15282   RIBG PROTEIN riboflavin-specific deaminase [EC: 3.5.4.—]       557   558   RXA02247   GR00654   15286   15918   RIBOFLAVIN SYNTHASE ALPHA CHAIN (EC 2.5.1.9)       559   560   RXN02248   VV0130   6021   7286   GTP CYCLOHYDROLASE II (EC 3.5.4.25)/3,4-DIHYDROXY-2-BUTANONE 4-                               PHOSPHATE SYNTHASE       561   562   F RXA02248   GR00654   15932   17197   RIBA PROTEIN - GTP cyclohydrolase II [EC: 3.5.4.25]       563   564   RXN02249   VV0130   7301   7777   6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE (EC 2.5.1.9)       565   566   F RXA02249   GR00654   17212   17688   RIBH PROTEIN - 6,7-dimethyl-8-ribityllumazine synthase (dmrl synthase, lumazine                               synthase, riboflavin synthase beta chain) [EC: 2.5.1.9]       567   568   RXA02250   GR00654   17778   18356   RIBX PROTEIN       569   570   RXA01489   GR00423   3410   2388   RIBOFLAVIN KINASE (EC 2.7.1.26)/FMN ADENYLYLTRANSFERASE (EC                               2.7.7.2)       571   572   RXA02135   GR00639   2809   1736   NICOTINATE-NUCLEOTIDE - DIMETHYLBENZIMIDAZOLE                               PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.21)       573   574   RXA01489   GR00423   3410   2388   RIBOFLAVIN KINASE (EC 2.7.1.26)/FMN ADENYLYLTRANSFERASE (EC                               2.7.7.2)       575   576   RXN01712   VV0191   8993   8298   RIBOFLAVIN-SPECIFIC DEAMINASE (EC 3.5.4.—)       577   578   F RXA01712   GR00484   2652   2152   RIBOFLAVIN-SPECIFIC DEAMINASE (EC 3.5.4.—)       579   580   RXN02384   VV0213   1386   679   ALPHA-RIBAZOLE-5′-PHOSPHATE PHOSPHATASE (EC 3.1.3.—)       581   582   RXN01560   VV0319   767   438   RIBOFLAVIN-SPECIFIC DEAMINASE (EC 3.5.4.—)       583   584   RXN00667   VV0109   1363   350   DRAP DEAMINASE       585   586   RXC01711               MEMBRANE SPANNING PROTEIN INVOLVED IN RIBOFLAVIN                               METABOLISM       587   588   RXC02380               PROTEIN INVOLVED IN RIBOFLAVIN METABOLISM       589   590   F RXA02380   GR00691   709   56   Predicted nucleotidyltransferases       591   592   RXC02921               CYTOSOLIC PROTEIN INVOLVED IN METABOLISM OF RIBOFLAVIN AND                               LIPIDS       593   594   RXC01434               MEMBRANE SPANNING PROTEIN INVOLVED IN METABOLISM                               OF AROMATIC AMINO ACIDS AND RIBOFLAVIN                 Vitamin B6 metabolism                                         595   596   RXA01807   GR00509   7868   7077   PYRIDOXINE KINASE (EC 2.7.1.35), pyridoxal/pyridoxine/pyridoxamine kinase                 Nicotinate (nicotinic acid), nicotinamide, NAD and NADP                                         597   598   RXN02754   VV0084   22564   23901   NICOTINATE PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.11)       599   600   F RXA02405   GR00701   774   4   NICOTINATE PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.11)       601   602   F RXA02754   GR00766   3   488   NICOTINATE PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.11)       603   604   RXA02112   GR00632   5600   6436   NICOTINATE-NUCLEOTIDE PYROPHOSPHORYLASE                               (CARBOXYLATING) (EC 2.4.2.19)       605   606   RXA02111   GR00632   4310   5593   QUINOLINATE SYNTHETASE A                 NAD Biosynthesis                                         607   608   RXA01073   GR00300   1274   2104   NH(3)-DEPENDENT NAD(+) SYNTHETASE (EC 6.3.5.1)       609   610   RXN02754   VV0084   22564   23901   NICOTINATE PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.11)                 Pantothenate and Coenzyme A (CoA) biosynthesis                                         611   612   RXA02299   GR00662   10452   10859   ASPARTATE 1-DECARBOXYLASE PRECURSOR (EC 4.1.1.11)       613   614   RXA01928   GR00555   1957   1121   PANTOATE - BETA-ALANINE LIGASE (EC 6.3.2.1)       615   616   RXN01929   VV0127   47590   48402   3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE                               (EC 2.1.2.11)/DECARBOXYLASE (EC 4.1.1.44)       617   618   F RXA01929   GR00555   2766   1960   3-METHYL-2-OXOBUTANOATE HYDROXYMETHYLTRANSFERASE                               (EC 2.1.2.11)       619   620   RXA01521   GR00424   25167   25964   PANTOATE - BETA-ALANINE LIGASE (EC 6.3.2.1)       621   622   RXS01145               KETOL-ACID REDUCTOISOMERASE (EC 1.1.1.86)       623   624   F RXA01145   GR00321   1075   1530   KETOL-ACID REDUCTOISOMERASE (EC 1.1.1.86)       625   626   RXA02239   GR00654   5784   7049   DNA/PANTOTHENATE METABOLISM FLAVOPROTEIN       627   628   RXA00581   GR00156   7572   8540   PANTOTHENATE KINASE (EC 2.7.1.33)       629   630   RXS00838               2-DEHYDROPANTOATE 2-REDUCTASE (EC 1.1.1.169)       631   632   RXC02238               PROTEIN INVOLVED IN METABOLISM OF S-ADENOSYLMETHIONINE,                               PURINES AND PANTOTHENATE                 Biotin metabolism                                         633   634   RXN03058   VV0028   8272   8754   BIOTIN SYNTHESIS PROTEIN BIOC       635   636   F RXA02903   GR10040   11532   12014   BIOTIN SYNTHESIS PROTEIN BIOC       637   638   RXA00166   GR00025   3650   4309   BIOTIN SYNTHESIS PROTEIN BIOC       639   640   RXA00633   GR00166   3556   2288   ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE                               AMINOTRANSFERASE (EC 2.6.1.62)       641   642   RXA00632   GR00166   2281   1610   DETHIOBIOTIN SYNTHETASE (EC 6.3.3.3)       643   644   RXA00295   GR00047   3407   4408   BIOTIN SYNTHASE (EC 2.8.1.6)       645   646   RXA00223   GR00032   23967   22879   NIFS PROTEIN       647   648   RXN00262   VV0123   16681   15608   NIFS PROTEIN       649   650   F RXA00262   GR00040   79   897   NIFS PROTEIN       651   652   RXN00435   VV0112   10037   11209   NIFS PROTEIN       653   654   F RXA00435   GR00100   3563   2949   NIFS PROTEIN       655   656   F RXA02801   GR00782   438   4   NIFS PROTEIN       657   658   RXA02516   GR00723   1724   2986   NIFS PROTEIN       659   660   RXA02517   GR00723   2989   3435   NIFU PROTEIN                 Lipoic Acid                                         661   662   RXA01747   GR00495   2506   3549   LIPOIC ACID SYNTHETASE       663   664   RXA01746   GR00495   1614   2366   LIPOATE-PROTEIN LIGASE B (EC 6.—.—.—)       665   666   RXA02106   GR00632   472   1527   LIPOATE-PROTEIN LIGASE A (EC 6.—.—.—)       667   668   RXS01183               DIHYDROLIPOAMIDE SUCCINYLTRANSFERASE COMPONENT (E2) OF 2-                               OXOGLUTARATE DEHYDROGENASE COMPLEX (EC 2.3.1.61)       669   670   RXS01260               LIPOAMIDE DEHYDROGENASE COMPONENT (E3) OF BRANCHED-CHAIN                               ALPHA-KETO ACID DEHYDROGENASE COMPLEX (EC 1.8.1.4)       671   672   RXS01261               LIPOAMIDE DEHYDROGENASE COMPONENT (E3) OF BRANCHED-CHAIN                               ALPHA-KETO ACID DEHYDROGENASE COMPLEX (EC 1.8.1.4)                 Folate biosynthesis                                         673   674   RXA02717   GR00758   18281   17400   5,10-METHYLENETETRAHYDROFOLATE REDUCTASE (EC 1.7.99.5)       675   676   RXN02027   VV0296   503   1003   5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE (EC 6.3.3.2)       677   678   F RXA02027   GR00616   500   6   5-FORMYLTETRAHYDROFOLATE CYCLO-LIGASE (EC 6.3.3.2)       679   680   RXA00106   GR00014   17469   17924   DIHYDROFOLATE REDUCTASE (EC 1.5.1.3)       681   682   RXN01321   VV0082   8868   9788   FORMYLTETRAHYDROFOLATE DEFORMYLASE (EC 3.5.1.10)       683   684   F RXA01321   GR00384   23   559   FORMYLTETRAHYDROFOLATE DEFORMYLASE (EC 3.5.1.10)       685   686   RXA00461   GR00116   428   1279   METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC 1.5.1.5)/                               METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC 3.5.4.9)       687   688   RXA01514   GR00424   20922   21509   GTP CYCLOHYDROLASE I (EC 3.5.4.16)       689   690   RXA01516   GR00424   22360   22749   DIHYDRONEOPTERIN ALDOLASE (EC 4.1.2.25)       691   692   RXA01515   GR00424   21513   22364   DIHYDROPTEROATE SYNTHASE (EC 2.5.1.15)       693   694   RXA02024   GR00613   4026   4784   DIHYDROPTEROATE SYNTHASE (EC 2.5.1.15)       695   696   RXA00106   GR00014   17469   17924   DIHYDROFOLATE REDUCTASE (EC 1.5.1.3)       697   698   RXA00989   GR00280   2903   1371   FOLYLPOLYGLUTAMATE SYNTHASE (EC 6.3.2.17)       699   700   RXA01517   GR00424   22752   23228   2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE                               PYROPHOSPHOKINASE (EC 2.7.6.3)       701   702   RXA00579   GR00156   5946   4087   PARA-AMINOBENZOATE SYNTHASE COMPONENT I (EC 4.1.3.—)       703   704   RXA00958   GR00264   1130   1753   PARA-AMINOBENZOATE SYNTHASE GLUTAMINE AMIDOTRANSFERASE                               COMPONENT II (EC 4.1.3.—)/ANTHRANILATE SYNTHASE COMPONENT                               II (EC 4.1.3.27)       705   706   RXA02790   GR00777   5806   6948   4-AMINO-4-DEOXYCHORISMATE LYASE (EC 4.—.—.—)       707   708   RXA00106   GR00014   17469   17924   DIHYDROFOLATE REDUCTASE (EC 1.5.1.3)       709   710   RXN02198   VV0302   9228   11726   5-METHYLTETRAHYDROFOLATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.13)       711   712   F RXA02198   GR00646   2483   6   5-METHYLTETRAHYDROFOLATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.13)       713   714   RXN02085   VV0126   8483   10717   5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE       715   716   F RXA02085   GR00629   3496   5295   5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.14)       717   718   F RXA02086   GR00629   5252   5731   5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.14)       719   720   RXN02648               5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.14)       721   722   F RXA02648   GR00751   5254   4730   5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.14)       723   724   F RXA02658   GR00752   14764   15447   5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.14)       725   726   RXS02197               5-METHYLTETRAHYDROFOLATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.13)       727   728   RXC00988               PROTEIN INVOLVED IN FOLATE METABOLISM       729   730   RXC01518               MEMBRANE SPANNING PROTEIN INVOLVED IN FOLATE METABOLISM       731   732   RXC01942               ATP-BINDING PROTEIN INVOLVED IN FOLATE METABOLISM                 Molybdopterin Metabolism                                         733   734   RXN02802   VV0112   17369   16299   MOLYBDOPTERIN BIOSYNTHESIS MOEB PROTEIN       735   736   F RXA02802   GR00783   7   474   MOLYBDOPTERIN BIOSYNTHESIS MOEB PROTEIN       737   738   F RXA00438   GR00103   362   796   MOLYBDOPTERIN BIOSYNTHESIS MOEB PROTEIN       739   740   RXN00437   VV0112   17824   17369   MOLYBDOPTERIN (MPT) CONVERTING FACTOR, SUBUNIT 2       741   742   F RXA00437   GR00103   3   362   MOLYBDOPTERIN (MPT) CONVERTING FACTOR, SUBUNIT 2       743   744   RXN00439   VV0112   18742   18275   MOLYBDOPTERIN CO-FACTOR SYNTHESIS PROTEIN       745   746   F RXA00439   GR00104   2   196   MOLYBDOPTERIN CO-FACTOR SYNTHESIS PROTEIN       747   748   F RXA00442   GR00105   830   1087   MOLYBDOPTERIN CO-FACTOR SYNTHESIS PROTEIN       749   750   RXA00440   GR00104   196   654   MOLYBDENUM COFACTOR BIOSYNTHESIS PROTEIN CB       751   752   RXN00441   VV0112   19942   18779   MOLYBDOPTERIN CO-FACTOR SYNTHESIS PROTEIN       753   754   F RXA00441   GR00105   2   793   MOLYBDOPTERIN CO-FACTOR SYNTHESIS PROTEIN       755   756   RXN02085               5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.14)       757   758   F RXA02085   GR00629   3496   5295   5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.14)       759   760   F RXA02086   GR00629   5252   5731   5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.14)       761   762   RXN02648               5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.14)       763   764   F RXA02648   GR00751   5254   4730   5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.14)       765   766   F RXA02658   GR00752   14764   15447   5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE - HOMOCYSTEINE                               METHYLTRANSFERASE (EC 2.1.1.14)       767   768   RXA01516   GR00424   22360   22749   DIHYDRONEOPTERIN ALDOLASE (EC 4.1.2.25)       769   770   RXA01515   GR00424   21513   22364   DIHYDROPTEROATE SYNTHASE (EC 2.5.1.15)       771   772   RXA02024   GR00613   4026   4784   DIHYDROPTEROATE SYNTHASE (EC 2.5.1.15)       773   774   RXA01719   GR00488   1264   704   MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS PROTEIN A       775   776   RXA01720   GR00488   2476   1268   MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN       777   778   RXS03223               MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN       779   780   F RXA01970   GR00568   2   1207   MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN       781   782   RXA02629   GR00748   1274   690   MOLYBDOPTERIN BIOSYNTHESIS CNX1 PROTEIN       783   784   RXA02318   GR00665   9684   9962   (D90909) pterin-4a-carbinolamine dehydratase [Synechocystis sp.]       785   786   RXA01517   GR00424   22752   23228   2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE                               PYROPHOSPHOKINASE (EC 2.7.6.3)       787   788   RXN01304   VV0148   4449   4934   MOLYBDOPTERIN BIOSYNTHESIS MOG PROTEIN       789   790   RXS02556               FLAVOHEMOPROTEIN/DIHYDROPTERIDINE REDUCTASE (EC 1.6.99.7)       791   792   RXS02560               OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE (EC 1.—.—.—)/                               DIHYDROPTERIDINE REDUCTASE (EC1.6.99.7)                 Vitamin B 12 , porphyrins and heme metabolism                                         793   794   RXA00382   GR00082   2752   1451   GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE (EC 5.4.3.8)       795   796   RXA00156   GR00023   10509   9400   FERROCHELATASE (EC 4.99.1.1)       797   798   RXA00624   GR00163   7910   8596   FERROCHELATASE (EC 4.99.1.1)       799   800   RXA00306   GR00051   2206   1274   HEMK PROTEIN       801   802   RXA00884   GR00242   10137   11276   OXYGEN-INDEPENDENT COPROPORPHYRINOGEN III OXIDASE                               (EC 1.—.—.—)       803   804   RXN02503   VV0007   22456   22854   PORPHOBILINOGEN DEAMINASE (EC 4.3.1.8)       805   806   F RXA02503   GR00720   16906   17340   PORPHOBILINOGEN DEAMINASE (EC 4.3.1.8)       807   808   RXA00377   GR00081   1427   306   UROPORPHYRINOGEN DECARBOXYLASE (EC 4.1.1.37)       809   810   RXN02504   VV0007   22805   23362   PORPHOBILINOGEN DEAMINASE (EC 4.3.1.8)       811   812   F RXA02504   GR00720   17379   17816   PORPHOBILINOGEN DEAMINASE (EC 4.3.1.8)       813   814   RXN01162   VV0088   1849   524   PRECORRIN-6Y METHYLASE (EC 2.1.1.—)       815   816   F RXA01162   GR00330   1248   4   PRECORRIN-6Y METHYLASE (EC 2.1.1.—)       817   818   RXA01692   GR00474   1498   749   UROPORPHYRIN-III C-METHYLTRANSFERASE (EC 2.1.1.107)       819   820   RXN00371   VV0226   4180   5973   UROPORPHYRIN-III C-METHYLTRANSFERASE (EC 2.1.1.107)/                               UROPORPHYRINOGEN-III SYNTHASE (EC 4.2.1.75)       821   822   F RXA00371   GR00078   929   6   UROPORPHYRIN-III C-METHYLTRANSFERASE (EC 2.1.1.107)/                               UROPORPHYRINOGEN-III SYNTHASE (EC 4.2.1.75)       823   824   F RXA00374   GR00079   1102   371   UROPORPHYRIN-III C-METHYLTRANSFERASE (EC 2.1.1.107)/                               UROPORPHYRINOGEN-III SYNTHASE (EC 4.2.1.75)       825   826   RXN00383   VV0223   4206   2863   PROTOPORPHYRINOGEN OXIDASE (EC 1.3.3.4)       827   828   F RXA00376   GR00081   287   6   PROTOPORPHYRINOGEN OXIDASE (EC 1.3.3.4)       829   830   F RXA00383   GR00082   3876   2863   PROTOPORPHYRINOGEN OXIDASE (EC 1.3.3.4)       831   832   RXA01253   GR00365   2536   1787   COBYRIC ACID SYNTHASE       833   834   RXA02134   GR00639   1721   801   COBALAMIN (5′-PHOSPHATE) SYNTHASE       835   836   RXA02135   GR00639   2809   1736   NICOTINATE-NUCLEOTIDE - DIMETHYLBENZIMIDAZOLE                               PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.21)       837   838   RXA02136   GR00639   3362   2841   COBINAMIDE KINASE/COBINAMIDE PHOSPHATE                               GUANYLYLTRANSFERASE       839   840   RXN03114   VV0088   1   552   COBG PROTEIN (EC 1.—.—.—)       841   842   RXN01810   VV0082   1739   663   HEMIN-BINDING PERIPLASMIC PROTEIN HMUT PRECURSOR       843   844   RXS03205               HEMK PROTEIN       845   846   F RXA00306               HEMK PROTEIN       847   848   RXC01715               CYTOSOLIC PROTEIN INVOLVED IN PORPHYRIN METABOLISM                 Vitamin C precursors                                         849   850   RXN00420   VV0112   2511   1048   L-GULONOLACTONE OXIDASE (EC 1.1.3.8)       851   852   F RXA00420   GR00096   2   541   L-GULONOLACTONE OXIDASE (EC 1.1.3.8)       853   854   F RXA00426   GR00097   1737   2258   L-GULONOLACTONE OXIDASE (EC 1.1.3.8)       855   856   RXN00708   VV0005   4678   3872   2,5-DIKETO-D-GLUCONIC ACID REDUCTASE (EC 1.1.1.—)       857   858   F RXA00708   GR00185   2030   1359   2,5-DIKETO-D-GLUCONIC ACID REDUCTASE (EC 1.1.1.—)       859   860   RXA02373   GR00688   1540   626   2,5-DIKETO-D-GLUCONIC ACID REDUCTASE (EC 1.1.1.—)       861   862   RXS00389               oxoglutarate semialdehyde dehydrogenase (EC 1.2.1.—)       863   864   RXS00419               ACETOACETYL-COA REDUCTASE (EC 1.1.1.36)       865   866   RXC00416               MEMBRANE SPANNING PROTEIN INVOLVED IN METABOLISM                               OF VITAMIN C PRECURSORS       867   868   RXC02206               OXIDOREDUCTASE INVOLVED IN METABOLISM OF VITAMIN                               C PRECURSORS                 Vitamin K2                                         869   870   RXS03074               S-ADENOSYLMETHIONINE: 2-DEMETHYLMENAQUINONE                               METHYLTRANSFERASE (EC 2.1.—.—)       871   872   F RXA02906   GR10044   1142   645   S-ADENOSYLMETHIONINE: 2-DEMETHYLMENAQUINONE                               METHYLTRANSFERASE (EC 2.1.—.—)       873   874   RXA02315   GR00665   8011   6383   2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE                               SYNTHASE/2-OXOGLUTARATE DECARBOXYLASE (EC 4.1.1.71)       875   876   RXA02319   GR00665   9977   10933   NAPHTHOATE SYNTHASE (EC 4.1.3.36)       877   878   RXS00393               1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE                               (EC 2.5.—.—)       879   880   F RXA00393   GR00086   4030   4911   1,4-DIHYDROXY-2-NAPHTHOATE OCTAPRENYLTRANSFERASE                               (EC 2.5.—.—)       881   882   RXA00391   GR00086   2031   2750   O-SUCCINYLBENZOIC ACID - COA LIGASE (EC 6.2.1.26)       883   884   RXS02908               O-SUCCINYLBENZOIC ACID - COA LIGASE (EC 6.2.1.26)                 Ubiquinone biosynthesis                                         885   886   RXA00997   GR00283   2389   1808   3-DEMETHYLUBIQUINONE-9 3-METHYLTRANSFERASE (EC 2.1.1.64)       887   888   RXA02189   GR00642   986   249   3-DEMETHYLUBIQUINONE-9 3-METHYLTRANSFERASE (EC 2.1.1.64)       889   890   RXA02311   GR00665   3073   2384   3-DEMETHYLUBIQUINONE-9 3-METHYLTRANSFERASE (EC 2.1.1.64)       891   892   RXN02912   VV0135   13299   12547   UBIQUINONE/MENAQUINONE BIOSYNTHESIS METHLYTRANSFERASE                               UBIE (EC 2.1.1.—)       893   894   RXS00998               COMA OPERON PROTEIN 2                 Purines and Pyrimidines and other Nucleotides       Regulation of purine and pyrimidine biosynthesis pathways       Purine metabolism       Purine Biosynthesis                                         895   896   RXA01215   GR00352   1187   213   RIBOSE-PHOSPHATE PYROPHOSPHOKINASE, PRPP synthetase (EC 2.7.6.1)       897   898   RXN00558   VV0103   8235   9581   AMIDOPHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.14)       899   900   F RXA00558   GR00148   61   501   AMIDOPHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.14)       901   902   RXN00626   VV0135   11624   10362   PHOSPHORIBOSYLAMINE - GLYCINE LIGASE (EC 6.3.4.13)       903   904   F RXA00629   GR00165   1450   1713   PHOSPHORIBOSYLAMINE-GLYCINE LIGASE (EC 6.3.4.13)       905   906   F RXA00626   GR00164   1   780   PHOSPHORIBOSYLAMINE - GLYCINE LIGASE, GARS (EC 6.3.4.13)       907   908   RXA02623   GR00746   4875   4285   PHOSPHORIBOSYLAMINE - GLYCINE LIGASE (EC 6.3.4.13)/                               PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE (EC 6.3.3.1)/                               PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE (EC 2.1.2.2)       909   910   RXA01442   GR00418   10277   9054   PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE 2 (EC 2.1.2.—)       911   912   RXN00537   VV0103   3351   5636   PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE (EC 6.3.5.3)       913   914   F RXA02805   GR00786   54   638   PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE (EC 6.3.5.3)       915   916   F RXA00537   GR00138   23   697   PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE (EC 6.3.5.3)       917   918   F RXA00561   GR00150   2   280   PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE (EC 6.3.5.3)       919   920   RXA00541   GR00139   2269   2937   PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE (EC 6.3.5.3)       921   922   RXA00620   GR00163   3049   3939   PHOSPHORIBOSYLAMIDOIMIDAZOLE-SUCCINOCARBOXAMIDE                               SYNTHASE (EC 6.3.2.6)       923   924   RXN00770   VV0103   9614   10783   PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE (EC 6.3.3.1)       925   926   F RXA00557   GR00147   15   818   PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE (EC 6.3.3.1)       927   928   F RXA00770   GR00204   7809   7495   PHOSPHORIBOSYLFORMYLGLYCINAMIDINE CYCLO-LIGASE (EC 6.3.3.1)       929   930   RXN02345   VV0078   4788   5984   PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ATPASE SUBUNIT                               (EC 4.1.1.21)       931   932   F RXA02345   GR00676   1534   725   PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE ATPASE                               SUBUNIT (EC 4.1.1.21)       933   934   RXN02350   VV0078   8369   8863   PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC                               SUBUNIT (EC 4.1.1.21)       935   936   F RXA02346   GR00677   127   5   PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC                               SUBUNIT (EC 4.1.1.21)       937   938   F RXA02350   GR00678   1120   911   PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE CATALYTIC                               SUBUNIT (EC 4.1.1.21)       939   940   RXA01087   GR00304   498   1373   PHOSPHORIBOSYLAMINOIMIDAZOLE CARBOXYLASE (EC 4.1.1.21)       941   942   RXA00619   GR00163   793   2220   ADENYLOSUCCINATE LYASE (EC 4.3.2.2)       943   944   RXA02622   GR00746   4274   2715   PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE                               FORMYLTRANSFERASE (EC 2.1.2.3)/IMP CYCLOHYDROLASE (EC 3.5.4.10)                 GMP, GDP, AMP and ADP synthesis, from inosine-5′-monophosphate (IMP)                                         945   946   RXN00488   VV0086   19066   20583   INOSINE-5′-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205)       947   948   F RXA00492   GR00122   1171   1644   INOSINE-5′-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205)       949   950   F RXA00488   GR00121   1   534   INOSINE-5′-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205)       951   952   RXA02469   GR00715   1927   497   INOSINE-5′-MONOPHOSPHATE DEHYDROGENASE (EC 1.1.1.205)       953   954   RXN00487   VV0086   23734   25302   GMP SYNTHASE [GLUTAMINE-HYDROLYZING] (EC 6.3.5.2)       955   956   F RXA00487   GR00120   712   2097   GMP SYNTHASE (EC 6.3.4.1)       957   958   RXA02237   GR00654   4577   5146   GUANYLATE KINASE (EC 2.7.4.8)       959   960   RXA01446   GR00418   17765   16476   ADENYLOSUCCINATE SYNTHETASE (EC 6.3.4.4)       961   962   RXA00619   GR00163   793   2220   ADENYLOSUCCINATE LYASE (EC 4.3.2.2)       963   964   RXA00688   GR00179   10443   10985   ADENYLATE KINASE (EC 2.7.4.3)       965   966   RXA00266   GR00040   3769   3362   NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6)                 GMP/AMP degrading activities                                         967   968   RXA00489   GR00121   654   1775   GMP REDUCTASE (EC 1.6.6.8)       969   970   RXN02281   VV0152   1893   3323   AMP NUCLEOSIDASE (EC 3.2.2.4)       971   972   F RXA02281   GR00659   1101   34   AMP NUCLEOSIDASE (EC 3.2.2.4)                 Pyrimidine metabolism       Pyrimidine biosynthesis de novo:                                         973   974   RXA00147   GR00022   9722   10900   CARBAMOYL-PHOSPHATE SYNTHASE SMALL CHAIN (EC 6.3.5.5)       975   976   RXA00145   GR00022   7258   8193   ASPARTATE CARBAMOYLTRANSFERASE CATALYTIC CHAIN (EC 2.1.3.2)       977   978   RXA00146   GR00022   8249   9589   DIHYDROOROTASE (EC 3.5.2.3)       979   980   RXA02208   GR00647   2   1003   DIHYDROOROTATE DEHYDROGENASE (EC 1.3.3.1)       981   982   RXA01660   GR00462   591   1142   OROTATE PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.10)       983   984   RXA02235   GR00654   3207   4040   OROTIDINE 5′-PHOSPHATE DECARBOXYLASE (EC 4.1.1.23)       985   986   RXN01892   VV0150   3020   3748   URIDYLATE KINASE (EC 2.7.4.—)       987   988   F RXA01892   GR00542   47   775   URIDYLATE KINASE (EC 2.7.4.—)       989   990   RXA00105   GR00014   16672   17346   THYMIDYLATE SYNTHASE (EC 2.1.1.45)       991   992   RXA00131   GR00020   7621   7013   THYMIDYLATE KINASE (EC 2.7.4.9)       993   994   RXA00266   GR00040   3769   3362   NUCLEOSIDE DIPHOSPHATE KINASE (EC 2.7.4.6)       995   996   RXA00718   GR00188   4576   5283   CYTIDYLATE KINASE (EC 2.7.4.14)       997   998   RXA01599   GR00447   8780   10441   CTP SYNTHASE (EC 6.3.4.2)       999   1000   RXN02234   VV0134   24708   28046   CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN (EC 6.3.5.5)       1001   1002   F RXA02234   GR00654   1   3198   CARBAMOYL-PHOSPHATE SYNTHASE LARGE CHAIN (EC 6.3.5.5)       1003   1004   RXN00450   VV0112   34491   34814   CYTOSINE DEAMINASE (EC 3.5.4.1)       1005   1006   F RXA00450   GR00110   322   5   CYTOSINE DEAMINASE (EC 3.5.4.1)       1007   1008   RXN02272   VV0020   15566   16810   CYTOSINE DEAMINASE (EC 3.5.4.1)       1009   1010   F RXA02272   GR00655   6691   7935   CREATININE DEAMINASE (EC 3.5.4.21)       1011   1012   RXN03004   VV0237   1862   2341   DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE (EC 3.5.4.13)       1013   1014   RXN03137   VV0129   9680   9579   THYMIDYLATE SYNTHASE (EC 2.1.1.45)       1015   1016   RXN03171   VV0328   568   1080   URACIL PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.9)       1017   1018   F RXA02857   GR10003   570   1082   URACIL PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.9)                 Purine and pyrimidine base, nucleoside and nucleotide salvage, interconversion, reduction and degradation:       Purines:                                         1019   1020   RXA02771   GR00772   1329   1883   ADENINE PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.7)       1021   1022   RXA01512   GR00424   17633   18232   HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE                               (EC 2.4.2.8)       1023   1024   RXA02031   GR00618   3820   3347   XANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.22)       1025   1026   RXA00981   GR00276   3388   4017   GTP PYROPHOSPHOKINASE (EC 2.7.6.5)       1027   1028   RXN02772   VV0171   2045   1011   GUANOSINE-3′,5′-BIS(DIPHOSPHATE)                               3′-PYROPHOSPHOHYDROLASE (EC 3.1.7.2)       1029   1030   F RXA02772   GR00772   1962   2741   GUANOSINE-3′,5′-BIS(DIPHOSPHATE)                               3′-PYROPHOSPHOHYDROLASE (EC 3.1.7.2)       1031   1032   F RXA02773   GR00772   2741   2902   GUANOSINE-3′,5′-BIS(DIPHOSPHATE)                               3′-PYROPHOSPHOHYDROLASE (EC 3.1.7.2)       1033   1034   RXA01835   GR00517   3147   3677   GUANOSINE-3′,5′-BIS(DIPHOSPHATE)                               3′-PYROPHOSPHOHYDROLASE (EC 3.1.7.2)       1035   1036   RXA01483   GR00422   19511   18240   DEOXYGUANOSINETRIPHOSPHATE TRIPHOSPHOHYDROLASE                               (EC 3.1.5.1)       1037   1038   RXN01027   VV0143   5761   6768   DIADENOSINE 5′,5′′′-P1,P4-TETRAPHOSPHATE HYDROLASE (EC 3.6.1.17)       1039   1040   F RXA01024   GR00293   661   5   DIADENOSINE 5′,5′′′-P1,P4-TETRAPHOSPHATE HYDROLASE (EC 3.6.1.17)       1041   1042   F RXA01027   GR00294   2580   2347   DIADENOSINE 5′,5′′′-P1,P4-TETRAPHOSPHATE HYDROLASE (EC 3.6.1.17)       1043   1044   RXA01528   GR00425   5653   5126   DIADENOSINE 5′,5′′′-P1,P4-TETRAPHOSPHATE HYDROLASE (EC 3.6.1.17)       1045   1046   RXA00072   GR00012   446   6   PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE (EC 1.8.99.4)       1047   1048   RXA01878   GR00537   1239   2117   DIMETHYLADENOSINE TRANSFERASE (EC 2.1.1.—)       1049   1050   RXN02281   VV0152   1893   3323   AMP NUCLEOSIDASE (EC 3.2.2.4)       1051   1052   F RXA02281   GR00659   1101   34   AMP NUCLEOSIDASE (EC 3.2.2.4)       1053   1054   RXN01240   VV0090   30442   29420   GTP PYROPHOSPHOKINASE (EC 2.7.6.5)       1055   1056   RXN02008   VV0171   1138   5   GUANOSINE-3′,5′-BIS(DIPHOSPHATE) 3′-PYROPHOSPHOHYDROLASE                               (EC 3.1.7.2)                 Pyrimdine and purine metabolism:                                         1057   1058   RXN01940   VV0120   10268   9333   INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE (EC 3.2.2.1)       1059   1060   F RXA01940   GR00557   3   581   INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE (EC 3.2.2.1)       1061   1062   RXA02559   GR00731   5418   6320   INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE (EC 3.2.2.1)       1063   1064   RXA02497   GR00720   10059   10985   EXOPOLYPHOSPHATASE (EC 3.6.1.11)       1065   1066   RXN01079   VV0084   38084   35982   RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (EC 1.17.4.1)       1067   1068   F RXA01079   GR00301   693   4   RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (EC 1.17.4.1)       1069   1070   F RXA01084   GR00302   3402   2062   RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE ALPHA CHAIN (EC 1.17.4.1)       1071   1072   RXN01920   VV0084   32843   31842   RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 2 BETA CHAIN (EC 1.17.4.1)       1073   1074   F RXA01920   GR00550   1321   908   RIBONUCLEOTIDE REDUCTASE SUBUNIT R2F       1075   1076   RXA01080   GR00301   1240   797   NRDI PROTEIN       1077   1078   RXA00867   GR00237   1   627   POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE (EC 2.7.7.8)       1079   1080   RXA01416   GR00413   2   631   POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE (EC 2.7.7.8)       1081   1082   RXA01486   GR00423   660   4   POLYRIBONUCLEOTIDE NUCLEOTIDYLTRANSFERASE (EC 2.7.7.8)       1083   1084   RXA01678   GR00467   7162   7689   2′,3′-CYCLIC-NUCLEOTIDE 2′-PHOSPHODIESTERASE (EC 3.1.4.16)       1085   1086   RXA01679   GR00467   7729   8964   2′,3′-CYCLIC-NUCLEOTIDE 2′-PHOSPHODIESTERASE (EC 3.1.4.16)       1087   1088   RXN01488   VV0139   39842   40789   INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE (EC 3.2.2.1)       1089   1090   RXC00540               CYTOSOLIC PROTEIN INVOLVED IN PURINE METABOLISM       1091   1092   RXC00560               PROTEIN INVOLVED IN PURINE METABOLISM       1093   1094   RXC01088               CYTOSOLIC PROTEIN INVOLVED IN PURINE METABOLISM       1095   1096   RXC02624               MEMBRANE SPANNING PROTEIN INVOLVED IN PURINE METABOLISM       1097   1098   RXC02665               PROTEIN INVOLVED IN PURINE METABOLISM       1099   1100   RXC02770               LIPOPROTEIN INVOLVED IN PURINE METABOLISM       1101   1102   RXC02238               PROTEIN INVOLVED IN METABOLISM OF S-ADENOSYLMETHIONINE,                               PURINES AND PANTOTHENATE       1103   1104   RXC01946               ABC TRANSPORTER ATP-BINDING PROTEIN INVOLVED IN PURINE                               METABOLISM                 Pyrimdines:                                         1105   1106   RXN03171   VV0328   568   1080   URACIL PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.9)       1107   1108   F RXA02857   GR10003   570   1082   URACIL PHOSPHORIBOSYLTRANSFERASE (EC 2.4.2.9)       1109   1110   RXN00450   VV0112   34491   34814   CYTOSINE DEAMINASE (EC 3.5.4.1)       1111   1112   F RXA00450   GR00110   322   5   CYTOSINE DEAMINASE (EC 3.5.4.1)       1113   1114   RXA00465   GR00117   337   828   CYTOSINE DEAMINASE (EC 3.5.4.1)       1115   1116   RXA00717   GR00188   3617   4576   RIBOSOMAL LARGE SUBUNIT PSEUDOURIDINE SYNTHASE B (EC 4.2.1.70)       1117   1118   RXA01894   GR00542   1622   2476   PHOSPHATIDATE CYTIDYLYLTRANSFERASE (EC 2.7.7.41)       1119   1120   RXA02536   GR00726   8581   7826   BETA-UREIDOPROPIONASE (EC 3.5.1.6)       1121   1122   RXN01209   VV0270   1019   2446   PHOSPHOMETHYLPYRIMIDINE KINASE (EC 2.7.4.7)       1123   1124   F RXA01209   GR00348   1019   2446   PHOSPHOMETHYLPYRIMIDINE KINASE (EC 2.7.4.7)       1125   1126   RXN01617   VV0050   22187   22858   PHOSPHOMETHYLPYRIMIDINE KINASE (EC 2.7.4.7)       1127   1128   F RXA01617   GR00451   2   616   PHOSPHOMETHYLPYRIMIDINE KINASE (EC 2.7.4.7)       1129   1130   RXC01600               CYTOSOLIC PROTEIN INVOLVED IN PYRIMIDINE METABOLISM       1131   1132   RXC01622               CYTOSOLIC PROTEIN INVOLVED IN PYRIMIDINE METABOLISM       1133   1134   RXC00128               EXPORTED PROTEIN INVOLVED IN METABOLISM OF PYRIDIMES AND                               ADENOSYLHOMOCYSTEINE       1135   1136   RXC01709               CYTOSOLIC PROTEIN INVOLVED IN PYRIMIDINE METABOLISM       1137   1138   RXC02207               EXPORTED PROTEIN INVOLVED IN PYRIMIDINE METABOLISM                 Sugars       Trehalose                                         1139   1140   RXA00347   GR00065   246   1013   TREHALOSE-PHOSPHATASE (EC 3.1.3.12)       1141   1142   RXN01239   VV0090   32921   30489   maltooligosyltrehalose synthase       1143   1144   F RXA01239   GR00358   5147   7579   maltooligosyltrehalose synthase       1145   1146   RXA02645   GR00751   714   2543   maltooligosyltrehalose trehalohydrolase       1147   1148   RXN02355   VV0051   735   4   TREHALOSE/MALTOSE BINDING PROTEIN       1149   1150   RXN02909   VV0135   38532   39017   Hypothetical Trehalose-Binding Protein       1151   1152   RXS00349               Hypothetical Trehalose Transport Protein       1153   1154   RXS03183               TREHALOSE/MALTOSE BINDING PROTEIN       1155   1156   RXC00874               TRANSMEBRANE PROTEIN INVOLVED IN TREHALOSE METABOLISM                  
 
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                   
               
               
                 GENES IDENTIFIED FROM GENBANK 
               
            
           
           
               
               
               
               
            
               
                 GenBank ™ 
                   
                   
                   
               
               
                 Accession 
                 Gene 
               
               
                 No. 
                 Name 
                 Gene Function 
                 Reference 
               
               
                   
               
               
                 A09073 
                 ppg 
                 Phosphoenol pyruvate carboxylase 
                 Bachmann, B. et al. “DNA fragment coding for phosphoenolpyruvat 
               
               
                   
                   
                   
                 corboxylase, recombinant DNA carrying said fragment, strains carrying the 
               
               
                   
                   
                   
                 recombinant DNA and method for producing L-aminino acids using said 
               
               
                   
                   
                   
                 strains,” Patent: EP 0358940-A 3 Mar. 21, 1990 
               
               
                 A45579, 
                   
                 Threonine dehydratase 
                 Moeckel, B. et al. “Production of L-isoleucine by means of recombinant 
               
               
                 A45581, 
                   
                   
                 micro-organisms with deregulated threonine dehydratase,” Patent: WO 
               
               
                 A45583, 
                   
                   
                 9519442-A 5 Jul. 20, 1995 
               
               
                 A45585 
               
               
                 A45587 
               
               
                 AB003132 
                 murC; 
                   
                 Kobayashi, M. et al. “Cloning, sequencing, and characterization of the ftsZ 
               
               
                   
                 ftsQ; ftsZ 
                   
                 gene from coryneform bacteria,” Biochem. Biophys. Res. Commun., 
               
               
                   
                   
                   
                 236(2): 383-388 (1997) 
               
               
                 AB015023 
                 murC; ftsQ 
                   
                 Wachi, M. et al. “A murC gene from Coryneform bacteria,” Appl. Microbiol. 
               
               
                   
                   
                   
                 Biotechnol., 51(2): 223-228 (1999) 
               
               
                 AB018530 
                 dtsR 
                   
                 Kimura, E. et al. “Molecular cloning of a novel gene, dtsR, which rescues the 
               
               
                   
                   
                   
                 detergent sensitivity of a mutant derived from  Brevibacterium   
               
               
                   
                   
                   
                   lactofermentum ,” Biosci. Biotechnol. Biochem., 60(10): 1565-1570 (1996) 
               
               
                 AB018531 
                 dtsR1; dtsR2 
               
               
                 AB020624 
                 murI 
                 D-glutamate racemase 
               
               
                 AB023377 
                 tkt 
                 transketolase 
               
               
                 AB024708 
                 gltB; gltD 
                 Glutamine 2-oxoglutarate 
               
               
                   
                   
                 aminotransferase large and small subunits 
               
               
                 AB025424 
                 acn 
                 aconitase 
               
               
                 AB027714 
                 rep 
                 Replication protein 
               
               
                 AB027715 
                 rep; aad 
                 Replication protein; aminoglycoside 
               
               
                   
                   
                 adenyltransferase 
               
               
                 AF005242 
                 argC 
                 N-acetylglutamate-5-semialdehyde 
               
               
                   
                   
                 dehydrogenase 
               
               
                 AF005635 
                 glnA 
                 Glutamine synthetase 
               
               
                 AF030405 
                 hisF 
                 cyclase 
               
               
                 AF030520 
                 argG 
                 Argininosuccinate synthetase 
               
               
                 AF031518 
                 argF 
                 Ornithine carbamolytransferase 
               
               
                 AF036932 
                 aroD 
                 3-dehydroquinate dehydratase 
               
               
                 AF038548 
                 pyc 
                 Pyruvate carboxylase 
               
               
                 AF038651 
                 dciAE; apt; 
                 Dipeptide-binding protein; adenine 
                 Wehmeier, L. et al. “The role of the  Corynebacterium glutamicum  rel gene in 
               
               
                   
                 rel 
                 phosphoribosyltransferase; GTP 
                 (p)ppGpp metabolism,” Microbiology, 144: 1853-1862 (1998) 
               
               
                   
                   
                 pyrophosphokinase 
               
               
                 AF041436 
                 argR 
                 Arginine repressor 
               
               
                 AF045998 
                 impA 
                 Inositol monophosphate phosphatase 
               
               
                 AF048764 
                 argH 
                 Argininosuccinate lyase 
               
               
                 AF049897 
                 argC; argJ; 
                 N-acetylglutamylphosphate reductase; 
               
               
                   
                 argB; argD; 
                 ornithine acetyltransferase; N- 
               
               
                   
                 argF; argR; 
                 acetylglutamate kinase; acetylornithine 
               
               
                   
                 argG; argH 
                 transminase; ornithine 
               
               
                   
                   
                 carbamoyltransferase; arginine repressor; 
               
               
                   
                   
                 argininosuccinate synthase; 
               
               
                   
                   
                 argininosuccinate lyase 
               
               
                 AF050109 
                 inhA 
                 Enoyl-acyl carrier protein reductase 
               
               
                 AF050166 
                 hisG 
                 ATP phosphoribosyltransferase 
               
               
                 AF051846 
                 hisA 
                 Phosphoribosylformimino-5-amino-1- 
               
               
                   
                   
                 phosphoribosyl-4-imidazolecarboxamide 
               
               
                   
                   
                 isomerase 
               
               
                 AF052652 
                 metA 
                 Homoserine O-acetyltransferase 
                 Park, S. et al. “Isolation and analysis of metA, a methionine biosynthetic gene 
               
               
                   
                   
                   
                 encoding homoserine acetyltransferase in  Corynebacterium glutamicum ,” Mol. 
               
               
                   
                   
                   
                 Cells., 8(3): 286-294 (1998) 
               
               
                 AF053071 
                 aroB 
                 Dehydroquinate synthetase 
               
               
                 AF060558 
                 hisH 
                 Glutamine amidotransferase 
               
               
                 AF086704 
                 hisE 
                 Phosphoribosyl-ATP- 
               
               
                   
                   
                 pyrophosphohydrolase 
               
               
                 AF114233 
                 aroA 
                 5-enolpyruvylshikimate 3-phosphate 
               
               
                   
                   
                 synthase 
               
               
                 AF116184 
                 panD 
                 L-aspartate-alpha-decarboxylase precursor 
                 Dusch, N. et al. “Expression of the  Corynebacterium glutamicum  panD gene 
               
               
                   
                   
                   
                 encoding L-aspartate-alpha-decarboxylase leads to pantothenate 
               
               
                   
                   
                   
                 overproduction in  Escherichia coli ,” Appl. Environ. Microbiol., 
               
               
                   
                   
                   
                 65(4)1530-1539 (1999) 
               
               
                 AF124518 
                 aroD; aroE 
                 3-dehydroquinase; shikimate 
               
               
                   
                   
                 dehydrogenase 
               
               
                 AF124600 
                 aroC; aroK; 
                 Chorismate synthase; shikimate kinase; 3- 
               
               
                   
                 aroB; pepQ 
                 dehydroquinate synthase; putative 
               
               
                   
                   
                 cytoplasmic peptidase 
               
               
                 AF145897 
                 inhA 
               
               
                 AF145898 
                 inhA 
               
               
                 AJ001436 
                 ectP 
                 Transport of ectoine, glycine betaine, 
                 Peter, H. et al. “ Corynebacterium glutamicum  is equipped with four secondary 
               
               
                   
                   
                 proline 
                 carriers for compatible solutes: Identification, sequencing, and characterization 
               
               
                   
                   
                   
                 of the proline/ectoine uptake system, ProP, and the ectoine/proline/glycine 
               
               
                   
                   
                   
                 betaine carrier, EctP,” J. Bacteriol., 180(22): 6005-6012 (1998) 
               
               
                 AJ004934 
                 dapD 
                 Tetrahydrodipicolinate succinylase 
                 Wehrmann, A. et al. “Different modes of diaminopimelate synthesis and their 
               
               
                   
                   
                 (incomplete i ) 
                 role in cell wall integrity: A study with  Corynebacterium glutamicum ,” J. 
               
               
                   
                   
                   
                 Bacteriol., 180(12): 3159-3165 (1998) 
               
               
                 AJ007732 
                 ppc; secG; 
                 Phosphoenolpyruvate-carboxylase; ?; high 
               
               
                   
                 amt; ocd; 
                 affinity ammonium uptake protein; 
               
               
                   
                 soxA 
                 putative ornithine-cyclodecarboxylase; 
               
               
                   
                   
                 sarcosine oxidase 
               
               
                 AJ010319 
                 ftsY, glnB, 
                 Involved in cell division; PII protein; 
                 Jakoby, M. et al. “Nitrogen regulation in  Corynebacterium glutamicum ; 
               
               
                   
                 glnD; srp; 
                 uridylyltransferase (uridylyl-removing 
                 Isolation of genes involved in biochemical characterization of corresponding 
               
               
                   
                 amtP 
                 enzmye); signal recognition particle; low 
                 proteins,” FEMS Microbiol., 173(2): 303-310 (1999) 
               
               
                   
                   
                 affinity ammonium uptake protein 
               
               
                 AJ132968 
                 cat 
                 Chloramphenicol aceteyl transferase 
               
               
                 AJ224946 
                 mqo 
                 L-malate: quinone oxidoreductase 
                 Molenaar, D. et al. “Biochemical and genetic characterization of the 
               
               
                   
                   
                   
                 membrane-associated malate dehydrogenase (acceptor) from  Corynebacterium   
               
               
                   
                   
                   
                   glutamicum ,” Eur. J. Biochem., 254(2): 395-403 (1998) 
               
               
                 AJ238250 
                 ndh 
                 NADH dehydrogenase 
               
               
                 AJ238703 
                 porA 
                 Porin 
                 Lichtinger, T. et al. “Biochemical and biophysical characterization of the cell 
               
               
                   
                   
                   
                 wall porin of  Corynebacterium glutamicum : The channel is formed by a low 
               
               
                   
                   
                   
                 molecular mass polypeptide,” Biochemistry, 37(43): 15024-15032 (1998) 
               
               
                 D17429 
                   
                 Transposable element IS31831 
                 Vertes et al. “Isolation and characterization of IS31831, a transposable element 
               
               
                   
                   
                   
                 from  Corynebacterium glutamicum ,” Mol. Microbiol., 11(4): 739-746 (1994) 
               
               
                 D84102 
                 odhA 
                 2-oxoglutarate dehydrogenase 
                 Usuda, Y. et al. “Molecular cloning of the  Corynebacterium glutamicum   
               
               
                   
                   
                   
                 ( Brevibacterium lactofermentum  AJ12036) odhA gene encoding a novel type 
               
               
                   
                   
                   
                 of 2-oxoglutarate dehydrogenase,” Microbiology, 142: 3347-3354 (1996) 
               
               
                 E01358 
                 hdh; hk 
                 Homoserine dehydrogenase; homoserine 
                 Katsumata, R. et al. “Production of L-thereonine and L-isoleucine,” Patent: JP 
               
               
                   
                   
                 kinase 
                 1987232392-A 1 Oct. 12, 1987 
               
               
                 E01359 
                   
                 Upstream of the start codon of homoserine 
                 Katsumata, R. et al. “Production of L-thereonine and L-isoleucine,” Patent: JP 
               
               
                   
                   
                 kinase gene 
                 1987232392-A 2 Oct. 12, 1987 
               
               
                 E01375 
                   
                 Tryptophan operon 
               
               
                 E01376 
                 trpL; trpE 
                 Leader peptide; anthranilate synthase 
                 Matsui, K. et al. “Tryptophan operon, peptide and protein coded thereby, 
               
               
                   
                   
                   
                 utilization of tryptophan operon gene expression and production of 
               
               
                   
                   
                   
                 tryptophan,” Patent: JP 1987244382-A 1 Oct. 24, 1987 
               
               
                 E01377 
                   
                 Promoter and operator regions of 
                 Matsui, K. et al. “Tryptophan operon, peptide and protein coded thereby, 
               
               
                   
                   
                 tryptophan operon 
                 utilization of tryptophan operon gene expression and production of 
               
               
                   
                   
                   
                 tryptophan,” Patent: JP 1987244382-A 1 Oct. 24, 1987 
               
               
                 E03937 
                   
                 Biotin-synthase 
                 Hatakeyama, K. et al. “DNA fragment containing gene capable of coding 
               
               
                   
                   
                   
                 biotin synthetase and its utilization,” Patent: JP 1992278088-A 1 Oct. 02, 1992 
               
               
                 E04040 
                   
                 Diamino pelargonic acid aminotransferase 
                 Kohama, K. et al. “Gene coding diaminopelargonic acid aminotransferase and 
               
               
                   
                   
                   
                 desthiobiotin synthetase and its utilization,” Patent: JP 1992330284-A 1 
               
               
                   
                   
                   
                 Nov. 18, 1992 
               
               
                 E04041 
                   
                 Desthiobiotinsynthetase 
                 Kohama, K. et al. “Gene coding diaminopelargonic acid aminotransferase and 
               
               
                   
                   
                   
                 desthiobiotin synthetase and its utilization,” Patent: JP 1992330284-A 1 
               
               
                   
                   
                   
                 Nov. 18, 1992 
               
               
                 E04307 
                   
                 Flavum aspartase 
                 Kurusu, Y. et al. “Gene DNA coding aspartase and utilization thereof,” Patent: 
               
               
                   
                   
                   
                 JP 1993030977-A 1 Feb. 09, 1993 
               
               
                 E04376 
                   
                 Isocitric acid lyase 
                 Katsumata, R. et al. “Gene manifestation controlling DNA,” Patent: JP 
               
               
                   
                   
                   
                 1993056782-A 3 Mar. 09, 1993 
               
               
                 E04377 
                   
                 Isocitric acid lyase N-terminal fragment 
                 Katsumata, R. et al. “Gene manifestation controlling DNA,” Patent: JP 
               
               
                   
                   
                   
                 1993056782-A 3 Mar. 09, 1993 
               
               
                 E04484 
                   
                 Prephenate dehydratase 
                 Sotouchi, N. et al. “Production of L-phenylalanine by fermentation,” Patent: JP 
               
               
                   
                   
                   
                 1993076352-A 2 Mar. 30, 1993 
               
               
                 E05108 
                   
                 Aspartokinase 
                 Fugono, N. et al. “Gene DNA coding Aspartokinase and its use,” Patent: JP 
               
               
                   
                   
                   
                 1993184366-A 1 Jul. 27, 1993 
               
               
                 E05112 
                   
                 Dihydro-dipichorinate synthetase 
                 Hatakeyama, K. et al. “Gene DNA coding dihydrodipicolinic acid synthetase 
               
               
                   
                   
                   
                 and its use,” Patent: JP 1993184371-A 1 Jul. 27, 1993 
               
               
                 E05776 
                   
                 Diaminopimelic acid dehydrogenase 
                 Kobayashi, M. et al. “Gene DNA coding Diaminopimelic acid dehydrogenase 
               
               
                   
                   
                   
                 and its use,” Patent: JP 1993284970-A 1 Nov. 02, 1993 
               
               
                 E05779 
                   
                 Threonine synthase 
                 Kohama, K. et al. “Gene DNA coding threonine synthase and its use,” Patent: 
               
               
                   
                   
                   
                 JP 1993284972-A 1 Nov. 02, 1993 
               
               
                 E06110 
                   
                 Prephenate dehydratase 
                 Kikuchi, T. et al. “Production of L-phenylalanine by fermentation method,” 
               
               
                   
                   
                   
                 Patent: JP 1993344881-A 1 Dec. 27, 1993 
               
               
                 E06111 
                   
                 Mutated Prephenate dehydratase 
                 Kikuchi, T. et al. “Production of L-phenylalanine by fermentation method,” 
               
               
                   
                   
                   
                 Patent: JP 1993344881-A 1 Dec. 27, 1993 
               
               
                 E06146 
                   
                 Acetohydroxy acid synthetase 
                 Inui, M. et al. “Gene capable of coding Acetohydroxy acid synthetase and its 
               
               
                   
                   
                   
                 use,” Patent: JP 1993344893-A 1 Dec. 27, 1993 
               
               
                 E06825 
                   
                 Aspartokinase 
                 Sugimoto, M. et al. “Mutant aspartokinase gene,” patent: JP 1994062866-A 1 
               
               
                   
                   
                   
                 Mar. 08, 1994 
               
               
                 E06826 
                   
                 Mutated aspartokinase alpha subunit 
                 Sugimoto, M. et al. “Mutant aspartokinase gene,” patent: JP 1994062866-A 1 
               
               
                   
                   
                   
                 Mar. 08, 1994 
               
               
                 E06827 
                   
                 Mutated aspartokinase alpha subunit 
                 Sugimoto, M. et al. “Mutant aspartokinase gene,” patent: JP 1994062866-A 1 
               
               
                   
                   
                   
                 Mar. 08, 1994 
               
               
                 E07701 
                 secY 
                   
                 Honno, N. et al. “Gene DNA participating in integration of membraneous 
               
               
                   
                   
                   
                 protein to membrane,” Patent: JP 1994169780-A 1 Jun. 21, 1994 
               
               
                 E08177 
                   
                 Aspartokinase 
                 Sato, Y. et al. “Genetic DNA capable of coding Aspartokinase released from 
               
               
                   
                   
                   
                 feedback inhibition and its utilization,” Patent: JP 1994261766-A 1 
               
               
                   
                   
                   
                 Sep. 20, 1994 
               
               
                 E08178, 
                   
                 Feedback inhibition-released 
                 Sato, Y. et al. “Genetic DNA capable of coding Aspartokinase released 
               
               
                 E08179, 
                   
                 Aspartokinase 
                 from feedback inhibition and its utilization,” Patent: JP 1994261766-A 1 
               
               
                 E08180, 
                   
                   
                 Sep. 20, 1994 
               
               
                 E08181, 
               
               
                 E08182 
               
               
                 E08232 
                   
                 Acetohydroxy-acid isomeroreductase 
                 Inui, M. et al. “Gene DNA coding acetohydroxy acid isomeroreductase,” 
               
               
                   
                   
                   
                 Patent: JP 1994277067-A 1 Oct. 04, 1994 
               
               
                 E08234 
                 secE 
                   
                 Asai, Y. et al. “Gene DNA coding for translocation machinery of protein,” 
               
               
                   
                   
                   
                 Patent: JP 1994277073-A 1 Oct. 04, 1994 
               
               
                 E08643 
                   
                 FT aminotransferase and desthiobiotin 
                 Hatakeyama, K. et al. “DNA fragment having promoter function in 
               
               
                   
                   
                 synthetase promoter region 
                 coryneform bacterium,” Patent: JP 1995031476-A 1 Feb. 03, 1995 
               
               
                 E08646 
                   
                 Biotin synthetase 
                 Hatakeyama, K. et al. “DNA fragment having promoter function in 
               
               
                   
                   
                   
                 coryneform bacterium,” Patent: JP 1995031476-A 1 Feb. 03, 1995 
               
               
                 E08649 
                   
                 Aspartase 
                 Kohama, K. et al “DNA fragment having promoter function in coryneform 
               
               
                   
                   
                   
                 bacterium,” Patent: JP 1995031478-A 1 Feb. 03, 1995 
               
               
                 E08900 
                   
                 Dihydrodipicolinate reductase 
                 Madori, M. et al. “DNA fragment containing gene coding Dihydrodipicolinate 
               
               
                   
                   
                   
                 acid reductase and utilization thereof,” Patent: JP 1995075578-A 1 
               
               
                   
                   
                   
                 Mar. 20, 1995 
               
               
                 E08901 
                   
                 Diaminopimelic acid decarboxylase 
                 Madori, M. et al. “DNA fragment containing gene coding Diaminopimelic acid 
               
               
                   
                   
                   
                 decarboxylase and utilization thereof,” Patent: JP 1995075579-A 1 
               
               
                   
                   
                   
                 Mar. 20, 1995 
               
               
                 E12594 
                   
                 Serine hydroxymethyltransferase 
                 Hatakeyama, K. et al. “Production of L-trypophan,” Patent: JP 1997028391-A 
               
               
                   
                   
                   
                 1 Feb. 4, 1997 
               
               
                 E12760, 
                   
                 transposase 
                 Moriya, M. et al. “Amplification of gene using artificial transposon,” Patent: 
               
               
                 E12759, 
                   
                   
                 JP 1997070291-A Mar. 18, 1997 
               
               
                 E12758 
               
               
                 E12764 
                   
                 Arginyl-tRNA synthetase; diaminopimelic 
                 Moriya, M. et al. “Amplification of gene using artificial transposon,” Patent: 
               
               
                   
                   
                 acid decarboxylase 
                 JP 1997070291-A Mar. 18, 1997 
               
               
                 E12767 
                   
                 Dihydrodipicolinic acid synthetase 
                 Moriya, M. et al. “Amplification of gene using artificial transposon,” Patent: 
               
               
                   
                   
                   
                 JP 1997070291-A Mar. 18, 1997 
               
               
                 E12770 
                   
                 aspartokinase 
                 Moriya, M. et al. “Amplification of gene using artificial transposon,” Patent: 
               
               
                   
                   
                   
                 JP 1997070291-A Mar. 18, 1997 
               
               
                 E12773 
                   
                 Dihydrodipicolinic acid reductase 
                 Moriya, M. et al. “Amplification of gene using artificial transposon,” Patent: 
               
               
                   
                   
                   
                 JP 1997070291-A Mar. 18, 1997 
               
               
                 E13655 
                   
                 Glucose-6-phosphate dehydrogenase 
                 Hatakeyama, K. et al. “Glucose-6-phosphate dehydrogenase and DNA capable 
               
               
                   
                   
                   
                 of coding the same,” Patent: JP 1997224661-A 1 Sep. 2, 1997 
               
               
                 L01508 
                 IlvA 
                 Threonine dehydratase 
                 Moeckel, B. et al. “Functional and structural analysis of the threonine 
               
               
                   
                   
                   
                 dehydratase of  Corynebacterium glutamicum ,” J. Bacteriol., 174: 8065-8072 
               
               
                   
                   
                   
                 (1992) 
               
               
                 L07603 
                 EC 4.2.1.15 
                 3-deoxy-D-arabinoheptulosonate-7- 
                 Chen, C. et al. “The cloning and nucleotide sequence of  Corynebacterium   
               
               
                   
                   
                 phosphate synthase 
                   glutamicum  3-deoxy-D-arabinoheptulosonate-7-phosphate synthase gene,” 
               
               
                   
                   
                   
                 FEMS Microbiol. Lett., 107: 223-230 (1993) 
               
               
                 L09232 
                 IlvB; ilvN; 
                 Acetohydroxy acid synthase large subunit; 
                 Keilhauer, C. et al. “Isoleucine synthesis in  Corynebacterium glutamicum : 
               
               
                   
                 ilvC 
                 Acetohydroxy acid synthase small subunit; 
                 molecular analysis of the ilvB-ilvN-ilvC operon,” J. Bacteriol., 175(17): 
               
               
                   
                   
                 Acetohydroxy acid isomeroreductase 
                 5595-5603 (1993) 
               
               
                 L18874 
                 PtsM 
                 Phosphoenolpyruvate sugar 
                 Fouet, A et al. “ Bacillus subtilis  sucrose-specific enzyme II of the 
               
               
                   
                   
                 phosphotransferase 
                 phosphotransferase system: expression in  Escherichia coli  and homology to 
               
               
                   
                   
                   
                 enzymes II from enteric bacteria,” PNAS USA, 84(24): 8773-8777 (1987); 
               
               
                   
                   
                   
                 Lee J. K. et al. “Nucleotide sequence of the gene encoding the 
               
               
                   
                   
                   
                   Corynebacterium glutamicum  mannose enzyme II and analyses of the deduced 
               
               
                   
                   
                   
                 protein sequence,” FEMS Microbiol. Lett., 119(1-2): 137-145 (1994) 
               
               
                 L27123 
                 aceB 
                 Malate synthase 
                 Lee, H-S. et al. “Molecular characterization of aceB, a gene encoding malate 
               
               
                   
                   
                   
                 synthase in  Corynebacterium glutamicum ,” J. Microbiol. Biotechnol., 
               
               
                   
                   
                   
                 4(4): 256-263 (1994) 
               
               
                 L27126 
                   
                 Pyruvate kinase 
                 Jetten, M. S. et al. “Structural and functional analysis of pyruvate kinase from 
               
               
                   
                   
                   
                   Corynebacterium glutamicum ,” Appl. Environ. Microbiol., 60(7): 2501-2507 
               
               
                   
                   
                   
                 (1994) 
               
               
                 L28760 
                 aceA 
                 Isocitrate lyase 
               
               
                 L35906 
                 dtxr 
                 Diphtheria toxin repressor 
                 Oguiza, J. A. et al. “Molecular cloning, DNA sequence analysis, and 
               
               
                   
                   
                   
                 characterization of the  Corynebacterium diphtheriae  dtxR from  Brevibacterium   
               
               
                   
                   
                   
                   lactofermentum ,” J. Bacteriol., 177(2): 465-467 (1995) 
               
               
                 M13774 
                   
                 Prephenate dehydratase 
                 Follettie, M. T. et al. “Molecular cloning and nucleotide sequence of the 
               
               
                   
                   
                   
                   Corynebacterium glutamicum  pheA gene,” J. Bacteriol., 167: 695-702 (1986) 
               
               
                 M16175 
                 5S rRNA 
                   
                 Park, Y-H. et al. “Phylogenetic analysis of the coryneform bacteria by 56 
               
               
                   
                   
                   
                 rRNA sequences,” J. Bacteriol., 169: 1801-1806 (1987) 
               
               
                 M16663 
                 trpE 
                 Anthranilate synthase, 5′ end 
                 Sano, K. et al. “Structure and function of the trp operon control regions of 
               
               
                   
                   
                   
                   Brevibacterium lactofermentum , a glutamic-acid-producing bacterium,” Gene, 
               
               
                   
                   
                   
                 52: 191-200 (1987) 
               
               
                 M16664 
                 trpA 
                 Tryptophan synthase, 3′end 
                 Sano, K. et al. “Structure and function of the trp operon control regions of 
               
               
                   
                   
                   
                   Brevibacterium lactofermentum , a glutamic-acid-producing bacterium,” Gene, 
               
               
                   
                   
                   
                 52: 191-200 (1987) 
               
               
                 M25819 
                   
                 Phosphoenolpyruvate carboxylase 
                 O&#39;Regan, M. et al. “Cloning and nucleotide sequence of the 
               
               
                   
                   
                   
                 Phosphoenolpyruvate carboxylase-coding gene of  Corynebacterium   
               
               
                   
                   
                   
                   glutamicum  ATCC13032,” Gene, 77(2): 237-251 (1989) 
               
               
                 M85106 
                   
                 23S rRNA gene insertion sequence 
                 Roller, C. et al. “Gram-positive bacteria with a high DNA G + C content are 
               
               
                   
                   
                   
                 characterized by a common insertion within their 23S rRNA genes,” J. Gen. 
               
               
                   
                   
                   
                 Microbiol., 138: 1167-1175 (1992) 
               
               
                 M85107, 
                   
                 23S rRNA gene insertion sequence 
                 Roller, C. et al. “Gram-positive bacteria with a high DNA G + C content are 
               
               
                 M85108 
                   
                   
                 characterized by a common insertion within their 23S rRNA genes,” J. Gen. 
               
               
                   
                   
                   
                 Microbiol., 138: 1167-1175 (1992) 
               
               
                 M89931 
                 aecD; brnQ; 
                 Beta C-S lyase; branched-chain amino 
                 Rossol, I. et al. “The  Corynebacterium glutamicum  aecD gene encodes a C-S 
               
               
                   
                 yhbw 
                 acid uptake carrier; hypothetical protein 
                 lyase with alpha, beta-elimination activity that degrades aminoethylcysteine,” 
               
               
                   
                   
                 yhbw 
                 J. Bacteriol., 174(9): 2968-2977 (1992); Tauch, A. et al. “Isoleucine uptake in 
               
               
                   
                   
                   
                   Corynebacterium glutamicum  ATCC 13032 is directed by the brnQ gene 
               
               
                   
                   
                   
                 product,” Arch. Microbiol., 169(4): 303-312 (1998) 
               
               
                 S59299 
                 trp 
                 Leader gene (promoter) 
                 Herry, D. M. et al. “Cloning of the trp gene cluster from a tryptophan- 
               
               
                   
                   
                   
                 hyperproducing strain of  Corynebacterium glutamicum : identification of a 
               
               
                   
                   
                   
                 mutation in the trp leader sequence,” Appl. Environ. Microbiol., 59(3): 
               
               
                   
                   
                   
                 791-799 (1993) 
               
               
                 U11545 
                 trpD 
                 Anthranilate phosphoribosyltransferase 
                 O&#39;Gara, J. P. and Dunican, L. K. (1994) Complete nucleotide sequence of the 
               
               
                   
                   
                   
                   Corynebacterium glutamicum  ATCC 21850 tpD gene.” Thesis, Microbiology 
               
               
                   
                   
                   
                 Department, University College Galway, Ireland. 
               
               
                 U13922 
                 cglIM; 
                 Putative type II 5-cytosoine 
                 Schafer, A. et al. “Cloning and characterization of a DNA region encoding a 
               
               
                   
                 cglIR; clgIIR 
                 methyltransferase; putative type II 
                 stress-sensitive restriction system from  Corynebacterium glutamicum  ATCC 
               
               
                   
                   
                 restriction endonuclease; putative type I or 
                 13032 and analysis of its role in intergeneric conjugation with  Escherichia   
               
               
                   
                   
                 type III restriction endonuclease 
                   coli ,” J. Bacteriol., 176(23): 7309-7319 (1994); Schafer, A. et al. “The 
               
               
                   
                   
                   
                   Corynebacterium glutamicum  cglIM gene encoding a 5-cytosine in an McrBC- 
               
               
                   
                   
                   
                 deficient  Escherichia coli  strain,” Gene, 203(2): 95-101 (1997) 
               
               
                 U14965 
                 recA 
               
               
                 U31224 
                 ppx 
                   
                 Ankri, S. et al. “Mutations in the  Corynebacterium glutamicumproline   
               
               
                   
                   
                   
                 biosynthetic pathway: A natural bypass of the proA step,” J. Bacteriol., 
               
               
                   
                   
                   
                 178(15): 4412-4419 (1996) 
               
               
                 U31225 
                 proC 
                 L-proline: NADP+ 5-oxidoreductase 
                 Ankri, S. et al. “Mutations in the  Corynebacterium glutamicumproline   
               
               
                   
                   
                   
                 biosynthetic pathway: A natural bypass of the proA step,” J. Bacteriol., 
               
               
                   
                   
                   
                 178(15): 4412-4419 (1996) 
               
               
                 U31230 
                 obg; proB; 
                 ?; gamma glutamyl kinase; similar to D- 
                 Ankri, S. et al. “Mutations in the  Corynebacterium glutamicumproline   
               
               
                   
                 unkdh 
                 isomer specific 2-hydroxyacid 
                 biosynthetic pathway: A natural bypass of the proA step,” J. Bacteriol., 
               
               
                   
                   
                 dehydrogenases 
                 178(15): 4412-4419 (1996) 
               
               
                 U31281 
                 bioB 
                 Biotin synthase 
                 Serebriiskii, I. G., “Two new members of the bio B superfamily: Cloning, 
               
               
                   
                   
                   
                 sequencing and expression of bio B genes of  Methylobacillus flagellatum  and 
               
               
                   
                   
                   
                   Corynebacterium glutamicum ,” Gene, 175: 15-22 (1996) 
               
               
                 U35023 
                 thtR; accBC 
                 Thiosulfate sulfurtransferase; acyl CoA 
                 Jager, W. et al. “A  Corynebacterium glutamicum  gene encoding a two-domain 
               
               
                   
                   
                 carboxylase 
                 protein similar to biotin carboxylases and biotin-carboxyl-carrier proteins,” 
               
               
                   
                   
                   
                 Arch. Microbiol., 166(2); 76-82 (1996) 
               
               
                 U43535 
                 cmr 
                 Multidrug resistance protein 
                 Jager, W. et al. “A  Corynebacterium glutamicum  gene conferring multidrug 
               
               
                   
                   
                   
                 resistance in the heterologous host  Escherichia coli ,” J. Bacteriol., 
               
               
                   
                   
                   
                 179(7): 2449-2451 (1997) 
               
               
                 U43536 
                 clpB 
                 Heat shock ATP-binding protein 
               
               
                 U53587 
                 aphA-3 
                 3′5″-aminoglycoside phosphotransferase 
               
               
                 U89648 
                   
                   Corynebacterium glutamicum  unidentified 
               
               
                   
                   
                 sequence involved in histidine 
               
               
                   
                   
                 biosynthesis, partial sequence 
               
               
                 X04960 
                 trpA; trpB; 
                 Tryptophan operon 
                 Matsui, K. et al. “Complete nucleotide and deduced amino acid sequences of 
               
               
                   
                 trpC; trpD; 
                   
                 the  Brevibacterium lactofermentum  tryptophan operon,” Nucleic Acids Res., 
               
               
                   
                 trpE; trpG; 
                   
                 14(24): 10113-10114 (1986) 
               
               
                   
                 trpL 
               
               
                 X07563 
                 lys A 
                 DAP decarboxylase (meso- 
                 Yeh, P. et al. “Nucleic sequence of the lysA gene of  Corynebacterium   
               
               
                   
                   
                 diaminopimelate decarboxylase, 
                   glutamicum  and possible mechanisms for modulation of its expression,” Mol. 
               
               
                   
                   
                 EC 4.1.1.20) 
                 Gen. Genet., 212(1): 112-119 (1988) 
               
               
                 X14234 
                 EC 4.1.1.31 
                 Phosphoenolpyruvate carboxylase 
                 Eikmanns, B. J. et al. “The Phosphoenolpyruvate carboxylase gene of 
               
               
                   
                   
                   
                   Corynebacterium glutamicum : Molecular cloning, nucleotide sequence, and 
               
               
                   
                   
                   
                 expression,” Mol. Gen. Genet., 218(2): 330-339 (1989); Lepiniec, L. et al. 
               
               
                   
                   
                   
                 “Sorghum Phosphoenolpyruvate carboxylase gene family: structure, function 
               
               
                   
                   
                   
                 and molecular evolution,” Plant. Mol. Biol., 21 (3): 487-502 (1993) 
               
               
                 X17313 
                 fda 
                 Fructose-bisphosphate aldolase 
                 Von der Osten, C. H. et al. “Molecular cloning, nucleotide sequence and fine- 
               
               
                   
                   
                   
                 structural analysis of the  Corynebacterium glutamicum  fda gene: structural 
               
               
                   
                   
                   
                 comparison of  C. glutamicum  fructose-1, 6-biphosphate aldolase to class I and 
               
               
                   
                   
                   
                 class II aldolases,” Mol. Microbiol., 
               
               
                 X53993 
                 dapA 
                 L-2,3-dihydrodipicolinate synthetase (EC 
                 Bonnassie, S. et al. “Nucleic sequence of the dapA gene from 
               
               
                   
                   
                 4.2.1.52) 
                   Corynebacterium glutamicum ,” Nucleic Acids Res., 18(21): 6421 (1990) 
               
               
                 X54223 
                   
                 AttB-related site 
                 Cianciotto, N. et al. “DNA sequence homology between att B-related sites of 
               
               
                   
                   
                   
                   Corynebacterium diphtheriae ,  Corynebacterium ulcerans ,  Corynebacterium   
               
               
                   
                   
                   
                   glutamicum , and the attP site of lambdacorynephage,” FEMS. Microbiol, 
               
               
                   
                   
                   
                 Lett., 66: 299-302 (1990) 
               
               
                 X54740 
                 argS; lysA 
                 Arginyl-tRNA synthetase; 
                 Marcel, T. et al. “Nucleotide sequence and organization of the upstream region 
               
               
                   
                   
                 Diaminopimelate decarboxylase 
                 of the  Corynebacterium glutamicum  lysA gene,” Mol. Microbiol., 4(11): 
               
               
                   
                   
                   
                 1819-1830 (1990) 
               
               
                 X55994 
                 trpL; trpE 
                 Putative leader peptide; anthranilate 
                 Heery, D. M. et al. “Nucleotide sequence of the  Corynebacterium glutamicum   
               
               
                   
                   
                 synthase component 1 
                 trpE gene,” Nucleic Acids Res., 18(23): 7138 (1990) 
               
               
                 X56037 
                 thrC 
                 Threonine synthase 
                 Han, K. S. et al. “The molecular structure of the  Corynebacterium glutamicum   
               
               
                   
                   
                   
                 threonine synthase gene,” Mol. Microbiol., 4(10): 1693-1702 (1990) 
               
               
                 X56075 
                 attB-related 
                 Attachment site 
                 Cianciotto, N. et al. “DNA sequence homology between att B-related sites of 
               
               
                   
                   
                 site 
                   Corynebacterium diphtheriae ,  Corynebacterium ulcerans ,  Corynebacterium   
               
               
                   
                   
                   
                   glutamicum , and the attP site of lambdacorynephage,” FEMS. Microbiol, 
               
               
                   
                   
                   
                 Lett., 66: 299-302 (1990) 
               
               
                 X57226 
                 lysC-alpha; 
                 Aspartokinase-alpha subunit; 
                 Kalinowski, J. et al. “Genetic and biochemical analysis of the Aspartokinase 
               
               
                   
                 lysC-beta; 
                 Aspartokinase-beta subunit; aspartate beta 
                 from  Corynebacterium glutamicum ,” Mol. Microbiol., 5(5): 1197-1204 (1991); 
               
               
                   
                 asd 
                 semialdehyde dehydrogenase 
                 Kalinowski, J. et al. “Aspartokinase genes lysC alpha and lysC beta overlap 
               
               
                   
                   
                   
                 and are adjacent to the aspertate beta-semialdehyde dehydrogenase gene asd in 
               
               
                   
                   
                   
                   Corynebacterium glutamicum ,” Mol. Gen. Genet., 224(3): 317-324 (1990) 
               
               
                 X59403 
                 gap; pgk; tpi 
                 Glyceraldehyde-3-phosphate; 
                 Eikmanns, B. J. “Identification, sequence analysis, and expression of a 
               
               
                   
                   
                 phosphoglycerate kinase; triosephosphate 
                   Corynebacterium glutamicum  gene cluster encoding the three glycolytic 
               
               
                   
                   
                 isomerase 
                 enzymes glyceraldehyde-3-phosphate dehydrogenase, 3-phosphoglycerate 
               
               
                   
                   
                   
                 kinase, and triosephosphate isomeras,” J. Bacteriol., 174(19): 6076-6086 
               
               
                   
                   
                   
                 (1992) 
               
               
                 X59404 
                 gdh 
                 Glutamate dehydrogenase 
                 Bormann, E. R. et al. “Molecular analysis of the  Corynebacterium glutamicum   
               
               
                   
                   
                   
                 gdh gene encoding glutamate dehydrogenase,” Mol. Microbiol., 6(3): 317-326 
               
               
                   
                   
                   
                 (1992) 
               
               
                 X60312 
                 lysI 
                 L-lysine permease 
                 Seep-Feldhaus, A. H. et al. “Molecular analysis of the  Corynebacterium   
               
               
                   
                   
                   
                   glutamicum  lysI gene involved in lysine uptake,” Mol. Microbiol., 5(12): 
               
               
                   
                   
                   
                 2995-3005 (1991) 
               
               
                 X66078 
                 cop1 
                 Ps1 protein 
                 Joliff, G. et al. “Cloning and nucleotide sequence of the csp1 gene encoding 
               
               
                   
                   
                   
                 PS1, one of the two major secreted proteins of  Corynebacterium glutamicum : 
               
               
                   
                   
                   
                 The deduced N-terminal region of PS1 is similar to the  Mycobacterium  antigen 
               
               
                   
                   
                   
                 85 complex,” Mol. Microbiol., 6(16): 2349-2362 (1992) 
               
               
                 X66112 
                 glt 
                 Citrate synthase 
                 Eikmanns, B. J. et al. “Cloning sequence, expression and transcriptional 
               
               
                   
                   
                   
                 analysis of the  Corynebacterium glutamicum  gltA gene encoding citrate 
               
               
                   
                   
                   
                 synthase,” Microbiol., 140: 1817-1828 (1994) 
               
               
                 X67737 
                 dapB 
                 Dihydrodipicolinate reductase 
               
               
                 X69103 
                 csp2 
                 Surface layer protein PS2 
                 Peyret, J. L. et al. “Characterization of the cspB gene encoding PS2, an ordered 
               
               
                   
                   
                   
                 surface-layer protein in  Corynebacterium glutamicum ,” Mol. Microbiol., 
               
               
                   
                   
                   
                 9(1): 97-109 (1993) 
               
               
                 X69104 
                   
                 IS3 related insertion element 
                 Bonamy, C. et al. “Identification of IS1206, a  Corynebacterium glutamicum   
               
               
                   
                   
                   
                 IS3-related insertion sequence and phylogenetic analysis,” Mol. Microbiol., 
               
               
                   
                   
                   
                 14(3): 571-581 (1994) 
               
               
                 X70959 
                 leuA 
                 Isopropylmalate synthase 
                 Patek, M. et al. “Leucine synthesis in  Corynebacterium glutamicum : enzyme 
               
               
                   
                   
                   
                 activities, structure of leuA, and effect of leuA inactivation on lysine 
               
               
                   
                   
                   
                 synthesis,” Appl. Environ. Microbiol., 60(1): 133-140 (1994) 
               
               
                 X71489 
                 icd 
                 Isocitrate dehydrogenase (NADP+) 
                 Eikmanns, B. J. et al. “Cloning sequence analysis, expression, and inactivation 
               
               
                   
                   
                   
                 of the  Corynebacterium glutamicum  icd gene encoding isocitrate 
               
               
                   
                   
                   
                 dehydrogenase and biochemical characterization of the enzyme,” J. Bacteriol., 
               
               
                   
                   
                   
                 177(3): 774-782 (1995) 
               
               
                 X72855 
                 GDHA 
                 Glutamate dehydrogenase (NADP+) 
               
               
                 X75083, 
                 mtrA 
                 5-methyltryptophan resistance 
                 Heery, D. M. et al. “A sequence from a tryptophan-hyperproducing strain of 
               
               
                 X70584 
                   
                   
                   Corynebacterium glutamicum  encoding resistance to 5-methyltryptophan,” 
               
               
                   
                   
                   
                 Biochem. Biophys. Res. Commun., 201(3): 1255-1262 (1994) 
               
               
                 X75085 
                 recA 
                   
                 Fitzpatrick, R. et al. “Construction and characterization of recA mutant strains 
               
               
                   
                   
                   
                 of  Corynebacterium glutamicum  and  Brevibacterium lactofermentum ,” Appl. 
               
               
                   
                   
                   
                 Microbiol. Biotechnol., 42(4): 575-580 (1994) 
               
               
                 X75504 
                 aceA; thiX 
                 Partial Isocitrate lyase; ? 
                 Reinscheid, D. J. et al. “Characterization of the isocitrate lyase gene from 
               
               
                   
                   
                   
                   Corynebacterium glutamicum  and biochemical analysis of the enzyme,” J. 
               
               
                   
                   
                   
                 Bacteriol., 176(12): 3474-3483 (1994) 
               
               
                 X76875 
                   
                 ATPase beta-subunit 
                 Ludwig, W. et al. “Phylogenetic relationships of bacteria based on comparative 
               
               
                   
                   
                   
                 sequence analysis of elongation factor Tu and ATP-synthase beta-subunit 
               
               
                   
                   
                   
                 genes,” Antonie Van Leeuwenhoek, 64: 285-305 (1993) 
               
               
                 X77034 
                 tuf 
                 Elongation factor Tu 
                 Ludwig, W. et al. “Phylogenetic relationships of bacteria based on comparative 
               
               
                   
                   
                   
                 sequence analysis of elongation factor Tu and ATP-synthase beta-subunit 
               
               
                   
                   
                   
                 genes,” Antonie Van Leeuwenhoek, 64: 285-305 (1993) 
               
               
                 X77384 
                 recA 
                   
                 Billman-Jacobe, H. “Nucleotide sequence of a recA gene from 
               
               
                   
                   
                   
                   Corynebacterium glutamicum ,” DNA Seq., 4(6): 403-404 (1994) 
               
               
                 X78491 
                 aceB 
                 Malate synthase 
                 Reinscheid, D. J. et al. “Malate synthase from  Corynebacterium glutamicum   
               
               
                   
                   
                   
                 pta-ack operon encoding phosphotransacetylase: sequence analysis,” 
               
               
                   
                   
                   
                 Microbiology, 140: 3099-3108 (1994) 
               
               
                 X80629 
                 16S rDNA 
                 16S ribosomal RNA 
                 Rainey, F. A. et al. “Phylogenetic analysis of the genera  Rhodococcus  and 
               
               
                   
                   
                   
                   Norcardia  and evidence for the evolutionary origin of the genus  Norcardia   
               
               
                   
                   
                   
                 from within the radiation of  Rhodococcus  species,” Microbiol., 141: 523-528 
               
               
                   
                   
                   
                 (1995) 
               
               
                 X81191 
                 gluA; gluB; 
                 Glutamate uptake system 
                 Kronemeyer, W. et al. “Structure of the gluABCD cluster encoding the 
               
               
                   
                 gluC; gluD 
                   
                 glutamate uptake system of  Corynebacterium glutamicum ,” J. Bacteriol., 
               
               
                   
                   
                   
                 177(5): 1152-1158 (1995) 
               
               
                 X81379 
                 dapE 
                 Succinyldiaminopimelate desuccinylase 
                 Wehrmann, A. et al. “Analysis of different DNA fragments of 
               
               
                   
                   
                   
                   Corynebacterium glutamicum  complementing dapE of  Escherichia coli ,” 
               
               
                   
                   
                   
                 Microbiology, 40: 3349-56 (1994) 
               
               
                 X82061 
                 16S rDNA 
                 16S ribosomal RNA 
                 Ruimy, R. et al. “Phylogeny of the genus  Corynebacterium  deduced from 
               
               
                   
                   
                   
                 analyses of small-subunit ribosomal DNA sequences,” Int. J. Syst. Bacteriol., 
               
               
                   
                   
                   
                 45(4): 740-746 (1995) 
               
               
                 X82928 
                 asd; lysC 
                 Aspartate-semialdehyde dehydrogenase; ? 
                 Serebrijski, I. et al. “Multicopy suppression by asd gene and osmotic stress- 
               
               
                   
                   
                   
                 dependent complementation by heterologous proA in proA mutants,” J. 
               
               
                   
                   
                   
                 Bacteriol., 177(24): 7255-7260 (1995) 
               
               
                 X82929 
                 proA 
                 Gamma-glutamyl phosphate reductase 
                 Serebrijski, I. et al. “Multicopy suppression by asd gene and osmotic stress- 
               
               
                   
                   
                   
                 dependent complementation by heterologous proA in proA mutants,” J. 
               
               
                   
                   
                   
                 Bacteriol., 177(24): 7255-7260 (1995) 
               
               
                 X84257 
                 16S rDNA 
                 16S ribosomal RNA 
                 Pascual, C. et al. “Phylogenetic analysis of the genus  Corynebacterium  based 
               
               
                   
                   
                   
                 on 16S rRNA gene sequences,” Int. J. Syst. Bacteriol., 45(4): 724-728 (1995) 
               
               
                 X85965 
                 aroP; dapE 
                 Aromatic amino acid permease; ? 
                 Wehrmann et al. “Functional analysis of sequences adjacent to dapE of 
               
               
                   
                   
                   
                   C. glutamicum  proline reveals the presence of aroP, which encodes the 
               
               
                   
                   
                   
                 aromatic amino acid transporter,” J. Bacteriol., 177(20): 5991-5993 (1995) 
               
               
                 X86157 
                 argB; argC; 
                 Acetylglutamate kinase; N-acetyl-gamma- 
                 Sakanyan, V. et al. “Genes and enzymes of the acetyl cycle of arginine 
               
               
                   
                 argD; argF; 
                 glutamyl-phosphate reductase; 
                 biosynthesis in  Corynebacterium glutamicum : enzyme evolution in the early 
               
               
                   
                 argJ 
                 acetylornithine aminotransferase; ornithine 
                 steps of the arginine pathway,” Microbiology, 142: 99-108 (1996) 
               
               
                   
                   
                 carbamoyltransferase; glutamate N- 
               
               
                   
                   
                 acetyltransferase 
               
               
                 X89084 
                 pta; ackA 
                 Phosphate acetyltransferase; acetate kinase 
                 Reinscheid, D. J. et al. “Cloning, sequence analysis, expression and 
               
               
                   
                   
                   
                 inactivation of the  Corynebacterium glutamicum  pta-ack operon encoding 
               
               
                   
                   
                   
                 phosphotransacetylase and acetate kinase,” Microbiology, 145: 503-513 (1999) 
               
               
                 X89850 
                 attB 
                 Attachment site 
                 Le Marrec, C. et al. “Genetic characterization of site-specific integration 
               
               
                   
                   
                   
                 functions of phi AAU2 infecting “ Arthrobacter aureus  C70,” J. Bacteriol., 
               
               
                   
                   
                   
                 178(7): 1996-2004 (1996) 
               
               
                 X90356 
                   
                 Promoter fragment F1 
                 Patek, M. et al. “Promoters from  Corynebacterium glutamicum : cloning, 
               
               
                   
                   
                   
                 molecular analysis and search for a consensus motif,” Microbiology, 
               
               
                   
                   
                   
                 142: 1297-1309 (1996) 
               
               
                 X90357 
                   
                 Promoter fragment F2 
                 Patek, M. et al. “Promoters from  Corynebacterium glutamicum : cloning, 
               
               
                   
                   
                   
                 molecular analysis and search for a consensus motif,” Microbiology, 
               
               
                   
                   
                   
                 142: 1297-1309 (1996) 
               
               
                 X90358 
                   
                 Promoter fragment F10 
                 Patek, M. et al. “Promoters from  Corynebacterium glutamicum : cloning, 
               
               
                   
                   
                   
                 molecular analysis and search for a consensus motif,” Microbiology, 
               
               
                   
                   
                   
                 142: 1297-1309 (1996) 
               
               
                 X90359 
                   
                 Promoter fragment F13 
                 Patek, M. et al. “Promoters from  Corynebacterium glutamicum : cloning, 
               
               
                   
                   
                   
                 molecular analysis and search for a consensus motif,” Microbiology, 
               
               
                   
                   
                   
                 142: 1297-1309 (1996) 
               
               
                 X90360 
                   
                 Promoter fragment F22 
                 Patek, M. et al. “Promoters from  Corynebacterium glutamicum : cloning, 
               
               
                   
                   
                   
                 molecular analysis and search for a consensus motif,” Microbiology, 
               
               
                   
                   
                   
                 142: 1297-1309 (1996) 
               
               
                 X90361 
                   
                 Promoter fragment F34 
                 Patek, M. et al. “Promoters from  Corynebacterium glutamicum : cloning, 
               
               
                   
                   
                   
                 molecular analysis and search for a consensus motif,” Microbiology, 
               
               
                   
                   
                   
                 142: 1297-1309 (1996) 
               
               
                 X90362 
                   
                 Promoter fragment F37 
                 Patek, M. et al. “Promoters from  C. glutamicum : cloning, molecular analysis 
               
               
                   
                   
                   
                 and search for a consensus motif,” Microbiology 142: 1297-1309 (1996) 
               
               
                 X90363 
                   
                 Promoter fragment F45 
                 Patek, M. et al. “Promoters from  Corynebacterium glutamicum : cloning, 
               
               
                   
                   
                   
                 molecular analysis and search for a consensus motif,” Microbiology, 
               
               
                   
                   
                   
                 142: 1297-1309 (1996) 
               
               
                 X90364 
                   
                 Promoter fragment F64 
                 Patek, M. et al. “Promoters from  Corynebacterium glutamicum : cloning, 
               
               
                   
                   
                   
                 molecular analysis and search for a consensus motif,” Microbiology, 
               
               
                   
                   
                   
                 142: 1297-1309 (1996) 
               
               
                 X90365 
                   
                 Promoter fragment F75 
                 Patek, M. et al. “Promoters from  Corynebacterium glutamicum : cloning, 
               
               
                   
                   
                   
                 molecular analysis and search for a consensus motif,” Microbiology, 
               
               
                   
                   
                   
                 142: 1297-1309 (1996) 
               
               
                 X90366 
                   
                 Promoter fragment PF101 
                 Patek, M. et al. “Promoters from  Corynebacterium glutamicum : cloning, 
               
               
                   
                   
                   
                 molecular analysis and search for a consensus motif,” Microbiology, 
               
               
                   
                   
                   
                 142: 1297-1309 (1996) 
               
               
                 X90367 
                   
                 Promoter fragment PF104 
                 Patek, M. et al. “Promoters from  Corynebacterium glutamicum : cloning, 
               
               
                   
                   
                   
                 molecular analysis and search for a consensus motif,” Microbiology, 
               
               
                   
                   
                   
                 142: 1297-1309 (1996) 
               
               
                 X90368 
                   
                 Promoter fragment PF109 
                 Patek, M. et al. “Promoters from  Corynebacterium glutamicum : cloning, 
               
               
                   
                   
                   
                 molecular analysis and search for a consensus motif,” Microbiology, 
               
               
                   
                   
                   
                 142: 1297-1309 (1996) 
               
               
                 X93513 
                 amt 
                 Ammonium transport system 
                 Siewe, R. M. et al. “Functional and genetic characterization of the (methyl) 
               
               
                   
                   
                   
                 ammonium uptake carrier of  Corynebacterium glutamicum ,” J. Biol. Chem., 
               
               
                   
                   
                   
                 271(10): 5398-5403 (1996) 
               
               
                 X93514 
                 betP 
                 Glycine betaine transport system 
                 Peter, H. et al. “Isolation, characterization, and expression of the 
               
               
                   
                   
                   
                   Corynebacterium glutamicum  betP gene, encoding the transport system for the 
               
               
                   
                   
                   
                 compatible solute glycine betaine,” J. Bacteriol., 178(17): 5229-5234 (1996) 
               
               
                 X95649 
                 orf4 
                   
                 Patek, M. et al. “Identification and transcriptional analysis of the dapB-ORF2- 
               
               
                   
                   
                   
                 dapA-ORF4 operon of  Corynebacterium glutamicum , encoding two enzymes 
               
               
                   
                   
                   
                 involved in L-lysine synthesis,” Biotechnol. Lett., 19: 1113-1117 (1997) 
               
               
                 X96471 
                 lysE; lysG 
                 Lysine exporter protein; Lysine export 
                 Vrljic, M. et al. “A new type of transporter with a new type of cellular 
               
               
                   
                   
                 regulator protein 
                 function: L-lysine export from  Corynebacterium glutamicum ,” Mol. 
               
               
                   
                   
                   
                 Microbiol., 22(5): 815-826 (1996) 
               
               
                 X96580 
                 panB; panC; 
                 3-methyl-2-oxobutanoate 
                 Sahm, H. et al. “D-pantothenate synthesis in  Corynebacterium glutamicum  and 
               
               
                   
                 xylB 
                 hydroxymethyltransferase; pantoate-beta- 
                 use of panBC and genes encoding L-valine synthesis for D-pantothenate 
               
               
                   
                   
                 alanine ligase; xylulokinase 
                 overproduction,” Appl. Environ. Microbiol., 65(5): 1973-1979 (1999) 
               
               
                 X96962 
                   
                 Insertion sequence IS1207 and transposase 
               
               
                 X99289 
                   
                 Elongation factor P 
                 Ramos, A. et al. “Cloning, sequencing and expression of the gene encoding 
               
               
                   
                   
                   
                 elongation factor P in the amino-acid producer  Brevibacterium lactofermentum   
               
               
                   
                   
                   
                 ( Corynebacterium glutamicum  ATCC 13869),” Gene, 198: 217-222 (1997) 
               
               
                 Y00140 
                 thrB 
                 Homoserine kinase 
                 Mateos, L. M. et al. “Nucleotide sequence of the homoserine kinase 
               
               
                   
                   
                   
                 (thrB) gene of the  Brevibacterium lactofermentum ,” Nucleic Acids 
               
               
                   
                   
                   
                 Res., 15(9): 3922 (1987) 
               
               
                 Y00151 
                 ddh 
                 Meso-diaminopimelate D-dehydrogenase 
                 Ishino, S. et al. “Nucleotide sequence of the meso-diaminopimelate D- 
               
               
                   
                   
                 (EC 1.4.1.16) 
                 dehydrogenase gene from  Corynebacterium glutamicum ,” Nucleic Acids Res., 
               
               
                   
                   
                   
                 15(9): 3917 (1987) 
               
               
                 Y00476 
                 thrA 
                 Homoserine dehydrogenase 
                 Mateos, L. M. et al. “Nucleotide sequence of the homoserine dehydrogenase 
               
               
                   
                   
                   
                 (thrA) gene of the  Brevibacterium lactofermentum ,” Nucleic Acids Res., 
               
               
                   
                   
                   
                 15(24): 10598 (1987) 
               
               
                 Y00546 
                 hom; thrB 
                 Homoserine dehydrogenase; homoserine 
                 Peoples, O. P. et al. “Nucleotide sequence and fine structural analysis of the 
               
               
                   
                   
                 kinase 
                   Corynebacterium glutamicum  hom-thrB operon,” Mol. Microbiol., 2(1): 63-72 
               
               
                   
                   
                   
                 (1988) 
               
               
                 Y08964 
                 murC; 
                 UPD-N-acetylmuramate-alanine ligase; 
                 Honrubia, M. P. et al. “Identification, characterization, and chromosomal 
               
               
                   
                 ftsQ/divD; 
                 division initiation protein or cell division 
                 organization of the ftsZ gene from  Brevibacterium lactofermentum ,” Mol. Gen. 
               
               
                   
                 ftsZ 
                 protein; cell division protein 
                 Genet., 259(1): 97-104 (1998) 
               
               
                 Y09163 
                 putP 
                 High affinity proline transport system 
                 Peter, H. et al. “Isolation of the putP gene of  Corynebacterium   
               
               
                   
                   
                   
                   glutamicumproline  and characterization of a low-affinity uptake system for 
               
               
                   
                   
                   
                 compatible solutes,” Arch. Microbiol., 168(2): 143-151 (1997) 
               
               
                 Y09548 
                 pyc 
                 Pyruvate carboxylase 
                 Peters-Wendisch, P. G. et al. “Pyruvate carboxylase from  Corynebacterium   
               
               
                   
                   
                   
                   glutamicum : characterization, expression and inactivation of the pyc gene,” 
               
               
                   
                   
                   
                 Microbiology, 144: 915-927 (1998) 
               
               
                 Y09578 
                 leuB 
                 3-isopropylmalate dehydrogenase 
                 Patek, M. et al. “Analysis of the leuB gene from  Corynebacterium   
               
               
                   
                   
                   
                   glutamicum ,” Appl. Microbiol. Biotechnol., 50(1): 42-47 (1998) 
               
               
                 Y12472 
                   
                 Attachment site bacteriophage Phi-16 
                 Moreau, S. et al. “Site-specific integration of corynephage Phi-16: The 
               
               
                   
                   
                   
                 construction of an integration vector,” Microbiol., 145: 539-548 (1999) 
               
               
                 Y12537 
                 proP 
                 Proline/ectoine uptake system protein 
                 Peter, H. et al. “ Corynebacterium glutamicum  is equipped with four secondary 
               
               
                   
                   
                   
                 carriers for compatible solutes: Identification, sequencing, and characterization 
               
               
                   
                   
                   
                 of the proline/ectoine uptake system, ProP, and the ectoine/proline/glycine 
               
               
                   
                   
                   
                 betaine carrier, EctP,” J. Bacteriol., 180(22): 6005-6012 (1998) 
               
               
                 Y13221 
                 glnA 
                 Glutamine synthetase I 
                 Jakoby, M. et al. “Isolation of  Corynebacterium glutamicum  glnA gene 
               
               
                   
                   
                   
                 encoding glutamine synthetase I,” FEMS Microbiol. Lett., 154(1): 
               
               
                   
                   
                   
                 81-88 (1997) 
               
               
                 Y16642 
                 lpd 
                 Dihydrolipoamide dehydrogenase 
               
               
                 Y18059 
                   
                 Attachment site Corynephage 304L 
                 Moreau, S. et al. “Analysis of the integration functions of &amp;phi; 304L: An 
               
               
                   
                   
                   
                 integrase module among corynephages,” Virology, 255(1): 150-159 (1999) 
               
               
                 Z21501 
                 argS; lysA 
                 Arginyl-tRNA synthetase; 
                 Oguiza, J. A. et al. “A gene encoding arginyl-tRNA synthetase is located in the 
               
               
                   
                   
                 diaminopimelate decarboxylase (partial) 
                 upstream region of the lysA gene in  Brevibacterium lactofermentum : 
               
               
                   
                   
                   
                 Regulation of argS-lysA cluster expression by arginine,” J. 
               
               
                   
                   
                   
                 Bacteriol., 175(22): 7356-7362 (1993) 
               
               
                 Z21502 
                 dapA; dapB 
                 Dihydrodipicolinate synthase; 
                 Pisabarro, A. et al. “A cluster of three genes (dapA, orf2, and dapB) of 
               
               
                   
                   
                 dihydrodipicolinate reductase 
                   Brevibacterium lactofermentum  encodes dihydrodipicolinate reductase, and a 
               
               
                   
                   
                   
                 third polypeptide of unknown function,” J. Bacteriol., 175(9): 2743-2749 
               
               
                   
                   
                   
                 (1993) 
               
               
                 Z29563 
                 thrC 
                 Threonine synthase 
                 Malumbres, M. et al. “Analysis and expression of the thrC gene of the encoded 
               
               
                   
                   
                   
                 threonine synthase,” Appl. Environ. Microbiol., 60(7)2209-2219 (1994) 
               
               
                 Z46753 
                 16S rDNA 
                 Gene for 16S ribosomal RNA 
               
               
                 Z49822 
                 sigA 
                 SigA sigma factor 
                 Oguiza, J. A. et al “Multiple sigma factor genes in  Brevibacterium   
               
               
                   
                   
                   
                   lactofermentum : Characterization of sigA and sigB,” J. Bacteriol., 178(2): 
               
               
                   
                   
                   
                 550-553 (1996) 
               
               
                 Z49823 
                 galE; dtxR 
                 Catalytic activity UDP-galactose 4- 
                 Oguiza, J. A. et al “The galE gene encoding the UDP-galactose 4-epimerase of 
               
               
                   
                   
                 epimerase; diphtheria toxin regulatory 
                   Brevibacterium lactofermentum  is coupled transcriptionally to the dmdR 
               
               
                   
                   
                 protein 
                 gene,” Gene, 177: 103-107 (1996) 
               
               
                 Z49824 
                 orfl; sigB 
                 ?; SigB sigma factor 
                 Oguiza, J. A. et al “Multiple sigma factor genes in  Brevibacterium   
               
               
                   
                   
                   
                   lactofermentum : Characterization of sigA and sigB,” J. Bacteriol., 178(2): 
               
               
                   
                   
                   
                 550-553 (1996) 
               
               
                 Z66534 
                   
                 Transposase 
                 Correia, A. et al. “Cloning and characterization of an IS-like element present in 
               
               
                   
                   
                   
                 the genome of  Brevibacterium lactofermentum  ATCC 13869,” Gene, 
               
               
                   
                   
                   
                 170(1): 91-94 (1996) 
               
               
                   
               
               
                     i A sequence for this gene was published in the indicated reference. However, the sequence obtained by the inventors of the present application is significantly longer than the published version. It is believed that the published version relied on an incorrect start codon, and thus represents only a fragment of the actual coding region.    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                   
               
               
                   Corynebacterium  and  Brevibacterium  Strains Which May be Used in the Practice of the Invention 
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 Genus 
                 species 
                 ATCC 
                 FERM 
                 NRRL 
                 CECT 
                 NCIMB 
                 CBS 
                 NCTC 
                 DSMZ 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 
                   Brevibacterium 
                 
                 
                   ammoniagenes 
                 
                 21054 
                   
                   
                   
                   
                   
                   
                   
               
               
                 
                   Brevibacterium 
                 
                 
                   ammoniagenes 
                 
                 19350 
               
               
                 
                   Brevibacterium 
                 
                 
                   ammoniagenes 
                 
                 19351 
               
               
                 
                   Brevibacterium 
                 
                 
                   ammoniagenes 
                 
                 19352 
               
               
                 
                   Brevibacterium 
                 
                 
                   ammoniagenes 
                 
                 19353 
               
               
                 
                   Brevibacterium 
                 
                 
                   ammoniagenes 
                 
                 19354 
               
               
                 
                   Brevibacterium 
                 
                 
                   ammoniagenes 
                 
                 19355 
               
               
                 
                   Brevibacterium 
                 
                 
                   ammoniagenes 
                 
                 19356 
               
               
                 
                   Brevibacterium 
                 
                 
                   ammoniagenes 
                 
                 21055 
               
               
                 
                   Brevibacterium 
                 
                 
                   ammoniagenes 
                 
                 21077 
               
               
                 
                   Brevibacterium 
                 
                 
                   ammoniagenes 
                 
                 21553 
               
               
                 
                   Brevibacterium 
                 
                 
                   ammoniagenes 
                 
                 21580 
               
               
                 
                   Brevibacterium 
                 
                 
                   ammoniagenes 
                 
                 39101 
               
               
                 
                   Brevibacterium 
                 
                 
                   butanicum 
                 
                 21196 
               
               
                 
                   Brevibacterium 
                 
                 
                   divaricatum 
                 
                 21792 
                 P928 
               
               
                 
                   Brevibacterium 
                 
                 
                   flavum 
                 
                 21474 
               
               
                 
                   Brevibacterium 
                 
                 
                   flavum 
                 
                 21129 
               
               
                 
                   Brevibacterium 
                 
                 
                   flavum 
                 
                 21518 
               
               
                 
                   Brevibacterium 
                 
                 
                   flavum 
                 
                   
                   
                 B11474 
               
               
                 
                   Brevibacterium 
                 
                 
                   flavum 
                 
                   
                   
                 B11472 
               
               
                 
                   Brevibacterium 
                 
                 
                   flavum 
                 
                 21127 
               
               
                 
                   Brevibacterium 
                 
                 
                   flavum 
                 
                 21128 
               
               
                 
                   Brevibacterium 
                 
                 
                   flavum 
                 
                 21427 
               
               
                 
                   Brevibacterium 
                 
                 
                   flavum 
                 
                 21475 
               
               
                 
                   Brevibacterium 
                 
                 
                   flavum 
                 
                 21517 
               
               
                 
                   Brevibacterium 
                 
                 
                   flavum 
                 
                 21528 
               
               
                 
                   Brevibacterium 
                 
                 
                   flavum 
                 
                 21529 
               
               
                 
                   Brevibacterium 
                 
                 
                   flavum 
                 
                   
                   
                 B11477 
               
               
                 
                   Brevibacterium 
                 
                 
                   flavum 
                 
                   
                   
                 B11478 
               
               
                 
                   Brevibacterium 
                 
                 
                   flavum 
                 
                 21127 
               
               
                 
                   Brevibacterium 
                 
                 
                   flavum 
                 
                   
                   
                 B11474 
               
               
                 
                   Brevibacterium 
                 
                 
                   healii 
                 
                 15527 
               
               
                 
                   Brevibacterium 
                 
                 
                   keto 
                   glutamicum 
                 
                 21004 
               
               
                 
                   Brevibacterium 
                 
                 
                   keto 
                   glutamicum 
                 
                 21089 
               
               
                 
                   Brevibacterium 
                 
                 
                   ketosoreductum 
                 
                 21914 
               
               
                 
                   Brevibacterium 
                 
                 
                   lactofermentum 
                 
                   
                   
                   
                 70 
               
               
                 
                   Brevibacterium 
                 
                 
                   lactofermentum 
                 
                   
                   
                   
                 74 
               
               
                 
                   Brevibacterium 
                 
                 
                   lactofermentum 
                 
                   
                   
                   
                 77 
               
               
                 
                   Brevibacterium 
                 
                 
                   lactofermentum 
                 
                 21798 
               
               
                 
                   Brevibacterium 
                 
                 
                   lactofermentum 
                 
                 21799 
               
               
                 
                   Brevibacterium 
                 
                 
                   lactofermentum 
                 
                 21800 
               
               
                 
                   Brevibacterium 
                 
                 
                   lactofermentum 
                 
                 21801 
               
               
                 
                   Brevibacterium 
                 
                 
                   lactofermentum 
                 
                   
                   
                 B11470 
               
               
                 
                   Brevibacterium 
                 
                 
                   lactofermentum 
                 
                   
                   
                 B11471 
               
               
                 
                   Brevibacterium 
                 
                 
                   lactofermentum 
                 
                 21086 
               
               
                 
                   Brevibacterium 
                 
                 
                   lactofermentum 
                 
                 21420 
               
               
                 
                   Brevibacterium 
                 
                 
                   lactofermentum 
                 
                 21086 
               
               
                 
                   Brevibacterium 
                 
                 
                   lactofermentum 
                 
                 31269 
               
               
                 
                   Brevibacterium 
                 
                 
                   linens 
                 
                 9174 
               
               
                 
                   Brevibacterium 
                 
                 
                   linens 
                 
                 19391 
               
               
                 
                   Brevibacterium 
                 
                 
                   linens 
                 
                 8377 
               
               
                 
                   Brevibacterium 
                 
                 
                   paraffinolyticum 
                 
                   
                   
                   
                   
                 11160 
               
               
                 
                   Brevibacterium 
                 
                 spec. 
                   
                   
                   
                   
                   
                 717.73 
               
               
                 
                   Brevibacterium 
                 
                 spec. 
                   
                   
                   
                   
                   
                 717.73 
               
               
                 
                   Brevibacterium 
                 
                 spec. 
                 14604 
               
               
                 
                   Brevibacterium 
                 
                 spec. 
                 21860 
               
               
                 
                   Brevibacterium 
                 
                 spec. 
                 21864 
               
               
                 
                   Brevibacterium 
                 
                 spec. 
                 21865 
               
               
                 
                   Brevibacterium 
                 
                 spec. 
                 21866 
               
               
                 
                   Brevibacterium 
                 
                 spec. 
                 19240 
               
               
                 
                   Corynebacterium 
                 
                 
                   acetoacidophilum 
                 
                 21476 
               
               
                 
                   Corynebacterium 
                 
                 
                   acetoacidophilum 
                 
                 13870 
               
               
                 
                   Corynebacterium 
                 
                 
                   aceto 
                   glutamicum 
                 
                   
                   
                 B11473 
               
               
                 
                   Corynebacterium 
                 
                 
                   aceto 
                   glutamicum 
                 
                   
                   
                 B11475 
               
               
                 
                   Corynebacterium 
                 
                 
                   aceto 
                   glutamicum 
                 
                 15806 
               
               
                 
                   Corynebacterium 
                 
                 
                   aceto 
                   glutamicum 
                 
                 21491 
               
               
                 
                   Corynebacterium 
                 
                 
                   aceto 
                   glutamicum 
                 
                 31270 
               
               
                 
                   Corynebacterium 
                 
                 
                   acetophilum 
                 
                   
                   
                 B3671 
               
               
                 
                   Corynebacterium 
                 
                 
                   ammoniagenes 
                 
                 6872 
                   
                   
                   
                   
                   
                 2399 
               
               
                 
                   Corynebacterium 
                 
                 
                   ammoniagenes 
                 
                 15511 
               
               
                 
                   Corynebacterium 
                 
                 
                   fujiokense 
                 
                 21496 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 14067 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 39137 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21254 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21255 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 31830 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 13032 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 14305 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 15455 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 13058 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 13059 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 13060 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21492 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21513 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21526 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21543 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 13287 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21851 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21253 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21514 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21516 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21299 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21300 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 39684 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21488 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21649 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21650 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 19223 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 13869 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21157 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21158 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21159 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21355 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 31808 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21674 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21562 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21563 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21564 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21565 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21566 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21567 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21568 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21569 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21570 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21571 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21572 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21573 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21579 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 19049 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 19050 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 19051 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 19052 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 19053 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 19054 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 19055 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 19056 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 19057 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 19058 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 19059 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 19060 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 19185 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 13286 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21515 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21527 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21544 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21492 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                   
                   
                 B8183 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                   
                   
                 B8182 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                   
                   
                 B12416 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                   
                   
                 B12417 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                   
                   
                 B12418 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                   
                   
                 B11476 
               
               
                 
                   Corynebacterium 
                 
                 
                   glutamicum 
                 
                 21608 
               
               
                 
                   Corynebacterium 
                 
                 
                   lilium 
                 
                   
                 P973 
               
               
                 
                   Corynebacterium 
                 
                 
                   nitrilophilus 
                 
                 21419 
                   
                   
                   
                 11594 
               
               
                 
                   Corynebacterium 
                 
                 spec. 
                   
                 P4445 
               
               
                 
                   Corynebacterium 
                 
                 spec. 
                   
                 P4446 
               
               
                 
                   Corynebacterium 
                 
                 spec. 
                 31088 
               
               
                 
                   Corynebacterium 
                 
                 spec. 
                 31089 
               
               
                 
                   Corynebacterium 
                 
                 spec. 
                 31090 
               
               
                 
                   Corynebacterium 
                 
                 spec. 
                 31090 
               
               
                 
                   Corynebacterium 
                 
                 spec. 
                 31090 
               
               
                 
                   Corynebacterium 
                 
                 spec. 
                 15954 
                   
                   
                   
                   
                   
                   
                 20145 
               
               
                 
                   Corynebacterium 
                 
                 spec. 
                 21857 
               
               
                 
                   Corynebacterium 
                 
                 spec. 
                 21862 
               
               
                 
                   Corynebacterium 
                 
                 spec. 
                 21863 
               
               
                   
               
               
                   ATCC: American Type Culture Collection, Rockville, MD, USA    
               
               
                   FERM: Fermentation Research Institute, Chiba, Japan    
               
               
                   NRRL: ARS Culture Collection, Northern Regional Research Laboratory, Peoria, IL, USA    
               
               
                   CECT: Coleccion Espanola de Cultivos Tipo, Valencia, Spain    
               
               
                   NCIMB: National Collection of Industrial and Marine Bacteria Ltd., Aberdeen, UK    
               
               
                   CBS: Centraalbureau voor Schimmelcultures, Baarn, NL    
               
               
                   NCTC: National Collection of Type Cultures, London, UK    
               
               
                   DSMZ: Deutsche Sammlung von Mikroorganismen und Zellkulturen, Braunschweig, Germany    
               
               
                   For reference see Sugawara, H. et al. (1993) World directory of collections of cultures of microorganisms: Bacteria, fungi and yeasts (4 th  edn), World federation for culture collections world data center on microorganisms, Saimata, Japen.    
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 4 
               
             
            
               
                   
               
               
                   
               
               
                 ALIGNMENT RESULTS 
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                   
                   
                 % 
                   
               
               
                   
                 length 
                   
                   
                   
                   
                   
                 homology 
                 Date of 
               
               
                 ID # 
                 (NT) 
                 Genbank Hit 
                 Length 
                 Accession 
                 Name of Genbank Hit 
                 Source of Genbank Hit 
                 (GAP) 
                 Deposit 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
            
               
                 rxa00023 
                 3579 
                 GB_EST33: AI776129 
                 483 
                 AI776129 
                 EST257217 tomato resistant, Cornell  Lycopersicon esculentum  cDNA clone 
                 
                   Lycopersicon esculentum 
                 
                 40,956 
                 29-Jun-99 
               
               
                   
                   
                   
                   
                   
                 cLER17D3, mRNA sequence. 
               
               
                   
                   
                 GB_EST33: AI776129 
                 483 
                 AI776129 
                 EST257217 tomato resistant, Cornell  Lycopersicon esculentum  cDNA clone 
                 
                   Lycopersicon esculentum 
                 
                 40,956 
                 29-Jun-99 
               
               
                   
                   
                   
                   
                   
                 cLER17D3, mRNA sequence. 
               
               
                 rxa00044 
                 1059 
                 EM_PAT: E11760 
                 6911 
                 E11760 
                 Base sequence of sucrase gene. 
                 
                   Corynebacterium glutamicum 
                 
                 42,979 
                 08-OCT-1997 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 (Rel. 52, 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Created) 
               
               
                   
                   
                 GB_PAT: I26124 
                 6911 
                 I26124 
                 Sequence 4 from patent U.S. Pat. No. 5556776. 
                 Unknown. 
                 42,979 
                 07-OCT-1996 
               
               
                   
                   
                 GB_BA2: ECOUW89 
                 176195 
                 U00006 
                   E. coli  chromosomal region from 89.2 to 92.8 minutes. 
                 
                   Escherichia coli 
                 
                 39,097 
                 17-DEC-1993 
               
               
                 rxa00064 
                 1401 
                 GB_PAT: E16763 
                 2517 
                 E16763 
                 gDNA encoding aspartate transferase (AAT). 
                 
                   Corynebacterium glutamicum 
                 
                 95,429 
                 28-Jul-99 
               
               
                   
                   
                 GB_HTG2: AC007892 
                 134257 
                 AC007892 
                   Drosophila melanogaster  chromosome 3 clone BACR02O03 (D797) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 31,111 
                 2-Aug-99 
               
               
                   
                   
                   
                   
                   
                 02.O.3 map 99B-99B strain y; cn bw sp, *** SEQUENCING IN PROGRESS 
               
               
                   
                   
                   
                   
                   
                 ***, 113 unordered pieces. 
               
               
                   
                   
                 GB_HTG2: AC007892 
                 134257 
                 AC007892 
                   Drosophila melanogaster  chromosome 3 clone BACR02O03 (D797) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 31,111 
                 2-Aug-99 
               
               
                   
                   
                   
                   
                   
                 02.O.3 map 99B-99B strain y; cn bw sp, *** SEQUENCING IN 
               
               
                   
                   
                   
                   
                   
                 PROGRESS***, 113 unordered pieces. 
               
               
                 rxa00072 
               
               
                 rxa00105 
                 798 
                 GB_BA1: MTV002 
                 56414 
                 AL008967 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 122/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 37,753 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: ECU29581 
                 71128 
                 U29581 
                   Escherichia coli  K-12 genome; approximately 63 to 64 minutes. 
                 
                   Escherichia coli 
                 
                 35,669 
                 14-Jan-97 
               
               
                   
                   
                 GB_BA2: AE000366 
                 10405 
                 AE000366 
                   Escherichia coli  K-12 MG1655 section 256 of 400 of the complete genome. 
                 
                   Escherichia coli 
                 
                 35,669 
                 12-Nov-98 
               
               
                 rxa00106 
                 579 
                 GB_EST15: AA494237 
                 367 
                 AA494237 
                 ng83f04.s1 NCI_CGAP_Pr6  Homo sapiens  cDNA clone IMAGE: 941407 
                 
                   Homo sapiens 
                 
                 42,896 
                 20-Aug-97 
               
               
                   
                   
                   
                   
                   
                 similar to SW: DYR_LACCA P00381 DIHYDROFOLATE REDUCTASE;, 
               
               
                   
                   
                   
                   
                   
                 mRNA sequence. 
               
               
                   
                   
                 GB_BA2: AF161327 
                 2021 
                 AF161327 
                   Corynebacterium diphtheriae  histidine kinase ChrS (chrS) and response 
                 
                   Corynebacterium diphtheriae 
                 
                 40,210 
                 9-Sep-99 
               
               
                   
                   
                   
                   
                   
                 regulator ChrA (chrA) genes, complete cds. 
               
               
                   
                   
                 GB_PAT: AR041189 
                 654 
                 AR041189 
                 Sequence 4 from patent U.S. Pat. No. 5811286. 
                 Unknown. 
                 41,176 
                 29-Sep-99 
               
               
                 rxa00115 
                 1170 
                 GB_PR4: AC007110 
                 148336 
                 AC007110 
                   Homo sapiens  chromosome 17, clone hRPK.472_J_18, complete sequence. 
                 
                   Homo sapiens 
                 
                 36,783 
                 30-MAR-1999 
               
               
                   
                   
                 GB_HTG3: AC008537 
                 170030 
                 AC008537 
                   Homo sapiens  chromosome 19 clone CIT-HSPC_490E21, *** SEQUENCING 
                 
                   Homo sapiens 
                 
                 40,296 
                 2-Sep-99 
               
               
                   
                   
                   
                   
                   
                 IN PROGRESS ***, 93 unordered pieces. 
               
               
                   
                   
                 GB_HTG3: AC008537 
                 170030 
                 AC008537 
                   Homo sapiens  chromosome 19 clone CIT-HSPC_490E21, *** SEQUENCING 
                 
                   Homo sapiens 
                 
                 40,296 
                 2-Sep-99 
               
               
                   
                   
                   
                   
                   
                 IN PROGRESS ***, 93 unordered pieces. 
               
               
                 rxa00116 
                 1284 
                 GB_BA2: AF062345 
                 16458 
                 AF062345 
                   Caulobacter crescentus  Sst1 (sst1), S-layer protein subunit (rsaA), ABC 
                 
                   Caulobacter crescentus 
                 
                 36,235 
                 19-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 transporter (rsaD), membrane forming unit (rsaE), putative GDP-mannose-4,6- 
               
               
                   
                   
                   
                   
                   
                 dehydratase (lpsA), putative acetyltransferase (lpsB), putative perosamine 
               
               
                   
                   
                   
                   
                   
                 synthetase (lpsC), putative mannosyltransferase (lpsD), putative 
               
               
                   
                   
                   
                   
                   
                 mannosyltransferase (lpsE), outer membrane protein (rsaF), and putative 
               
               
                   
                   
                   
                   
                   
                 perosamine transferase (lpsE) genes, complete cds. 
               
               
                   
                   
                 GB_PAT: I18647 
                 3300 
                 I18647 
                 Sequence 6 from patent U.S. Pat. No. 5500353. 
                 Unknown. 
                 36,821 
                 07-OCT-1996 
               
               
                   
                   
                 GB_GSS13: AQ446197 
                 751 
                 AQ446197 
                 nbxb0062D16r CUGI Rice BAC Library  Oryza sativa  genomic clone 
                 
                   Oryza sativa 
                 
                 38,124 
                 8-Apr-99 
               
               
                   
                   
                   
                   
                   
                 nbxb0062D16r, genomic survey sequence. 
               
               
                 rxa00131 
                 732 
                 GB_BA1: MTY20B11 
                 36330 
                 Z95121 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 139/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 43,571 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: SAR7932 
                 15176 
                 AJ007932 
                   Streptomyces argillaceus  mithramycin biosynthetic genes. 
                 
                   Streptomyces argillaceus 
                 
                 41,116 
                 15-Jun-99 
               
               
                   
                   
                 GB_BA1: MTY20B11 
                 36330 
                 Z95121 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 139/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 39,726 
                 17-Jun-98 
               
               
                 rxa00132 
                 1557 
                 GB_BA1: MTY20B11 
                 36330 
                 Z95121 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 139/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 36,788 
                 17-Jun-98 
               
               
                   
                   
                 GB_IN2: TVU40872 
                 1882 
                 U40872 
                   Trichomonas vaginalis  S-adenosyl-L-homocysteine hydrolase gene, complete 
                 
                   Trichomonas vaginalis 
                 
                 61,914 
                 31-OCT-1996 
               
               
                   
                   
                   
                   
                   
                 cds. 
               
               
                   
                   
                 GB_HTG6: AC010706 
                 169265 
                 AC010706 
                   Drosophila melanogaster  chromosome X clone BACR36D15 (D887) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 51,325 
                 22-Nov-99 
               
               
                   
                   
                   
                   
                   
                 36.D.15 map 13C-13E strain y; cn bw sp, *** SEQUENCING IN PROGRESS 
               
               
                   
                   
                   
                   
                   
                 ***, 74 unordered pieces. 
               
               
                 rxa00145 
                 1059 
                 GB_BA1: MTCY2B12 
                 20431 
                 Z81011 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 61/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 63,365 
                 18-Jun-98 
               
               
                   
                   
                 GB_BA1: PSEPYRBX 
                 2273 
                 L19649 
                   Pseudomonas aeruginosa  aspartate transcarbamoylase (pyrB) and 
                 
                   Pseudomonas aeruginosa 
                 
                 56,080 
                 26-Jul-93 
               
               
                   
                   
                   
                   
                   
                 dihydroorotase-like (pyrX) genes, complete cds&#39;s. 
               
               
                   
                   
                 GB_BA1: LLPYRBDNA 
                 1468 
                 X84262 
                   L. leichmannii  pyrB gene. 
                 
                   Lactobacillus leichmannii 
                 
                 47,514 
                 29-Apr-97 
               
               
                 rxa00146 
                 1464 
                 GB_BA1: MTCY2B12 
                 20431 
                 Z81011 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 61/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 60,714 
                 18-Jun-98 
               
               
                   
                   
                 GB_BA1: MTCY154 
                 13935 
                 Z98209 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 121/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 39,229 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MSGY154 
                 40221 
                 AD000002 
                   Mycobacterium tuberculosis  sequence from clone y154. 
                 
                   Mycobacterium tuberculosis 
                 
                 36,618 
                 03-DEC-1996 
               
               
                 rxa00147 
                 1302 
                 GB_BA1: MTCY2B12 
                 20431 
                 Z81011 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 61/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 61,527 
                 18-Jun-98 
               
               
                   
                   
                 GB_BA1: MSGB937CS 
                 38914 
                 L78820 
                   Mycobacterium leprae  cosmid B937 DNA sequence. 
                 
                   Mycobacterium leprae 
                 
                 59,538 
                 15-Jun-96 
               
               
                   
                   
                 GB_BA1: PAU81259 
                 7285 
                 U81259 
                   Pseudomonas aeruginosa  dihydrodipicolinate reductase (dapB) gene, partial 
                 
                   Pseudomonas aeruginosa 
                 
                 55,396 
                 23-DEC-1996 
               
               
                   
                   
                   
                   
                   
                 cds, carbamoylphosphate synthetase small subunit (carA) and 
               
               
                   
                   
                   
                   
                   
                 carbamoylphosphate synthetase large subunit (carB) genes, complete cds, 
               
               
                   
                   
                   
                   
                   
                 and FtsJ homolog (ftsJ) gene, partial cds. 
               
               
                 rxa00156 
                 1233 
                 GB_BA1: SC9B10 
                 33320 
                 AL009204 
                   Streptomyces coelicolor  cosmid 9B10. 
                 
                   Streptomyces coelicolor 
                 
                 52,666 
                 10-Feb-99 
               
               
                   
                   
                 GB_BA2: AF002133 
                 15437 
                 AF002133 
                   Mycobacterium avium  strain GIR10 transcriptional regulator (mav81) gene, 
                 
                   Mycobacterium avium 
                 
                 54,191 
                 26-MAR-1998 
               
               
                   
                   
                   
                   
                   
                 partial cds, aconitase (acn), invasin 1 (inv1), invasin 2 (inv2), transcriptional 
               
               
                   
                   
                   
                   
                   
                 regulator (moxR), ketoacyl-reductase (fabG), enoyl-reductase (inhA) and 
               
               
                   
                   
                   
                   
                   
                 ferrochelatase (mav272) genes, complete cds. 
               
               
                   
                   
                 GB_BA1: D85417 
                 7984 
                 D85417 
                   Propionibacterium freudenreichii  hemY, hemH, hemB, hemX, hemR and hemL 
                 
                   Propionibacterium 
                 
                 46,667 
                 6-Feb-99 
               
               
                   
                   
                   
                   
                   
                 genes, complete cds. 
                 
                   freudenreichii 
                 
               
               
                 rxa00166 
                 783 
                 GB_HTG3: AC008167 
                 174223 
                 AC008167 
                   Homo sapiens  clone NH0172O13, *** SEQUENCING IN PROGRESS ***, 7 
                 
                   Homo sapiens 
                 
                 37,451 
                 21-Aug-99 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                   
                   
                 GB_HTG3: AC008167 
                 174223 
                 AC008167 
                   Homo sapiens  clone NH0172O13, *** SEQUENCING IN PROGRESS ***, 7 
                 
                   Homo sapiens 
                 
                 37,451 
                 21-Aug-99 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                   
                   
                 GB_HTG4: AC010118 
                 80605 
                 AC010118 
                   Drosophila melanogaster  chromosome 3L/62B1 clone RPCI98-10D15, *** 
                 
                   Drosophila melanogaster 
                 
                 38,627 
                 16-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 SEQUENCING IN PROGRESS ***, 51 unordered pieces. 
               
               
                 rxa00198 
                 672 
                 GB_BA1: AB024708 
                 8734 
                 AB024708 
                   Corynebacterium glutamicum  gltB and gltD genes for glutamine 2-oxoglutarate 
                 
                   Corynebacterium glutamicum 
                 
                 92,113 
                 13-MAR-1999 
               
               
                   
                   
                   
                   
                   
                 aminotransferase large and small subunits, complete cds. 
               
               
                   
                   
                 GB_BA1: AB024708 
                 8734 
                 AB024708 
                   Corynebacterium glutamicum  gltB and gltD genes for glutamine 2-oxoglutarate 
                 
                   Corynebacterium glutamicum 
                 
                 93,702 
                 13-MAR-1999 
               
               
                   
                   
                   
                   
                   
                 aminotransferase large and small subunits, complete cds. 
               
               
                   
                   
                 GB_EST24: AI232702 
                 528 
                 AI232702 
                 EST229390 Normalized rat kidney, Bento Soares  Rattus  sp. cDNA clone 
                   Rattus  sp. 
                 34,221 
                 31-Jan-99 
               
               
                   
                   
                   
                   
                   
                 RKICF35 3′ end, mRNA sequence. 
               
               
                 rxa00216 
                 1113 
                 GB_HTG2: HSDJ850E9 
                 117353 
                 AL121758 
                   Homo sapiens  chromosome 20 clone RP5-850E9, *** SEQUENCING IN 
                 
                   Homo sapiens 
                 
                 37,965 
                 03-DEC-1999 
               
               
                   
                   
                   
                   
                   
                 PROGRESS ***, in unordered pieces. 
               
               
                   
                   
                 GB_HTG2: HSDJ850E9 
                 117353 
                 AL121758 
                   Homo sapiens  chromosome 20 clone RP5-850E9, *** SEQUENCING IN 
                 
                   Homo sapiens 
                 
                 37,965 
                 03-DEC-1999 
               
               
                   
                   
                   
                   
                   
                 PROGRESS ***, in unordered pieces. 
               
               
                   
                   
                 GB_PR2: CNS01DSA 
                 159400 
                 AL121766 
                 Human chromosome 14 DNA sequence *** IN PROGRESS *** BAC R-412H8 
                 
                   Homo sapiens 
                 
                 38,796 
                 11-Nov-99 
               
               
                   
                   
                   
                   
                   
                 of RPCI-11 library from chromosome 14 of  Homo sapiens  (Human), complete 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                 rxa00219 
                 1065 
                 GB_HTG2: AC005079_0 
                 110000 
                 AC005079 
                   Homo sapiens  clone RG252P22, *** SEQUENCING IN PROGRESS ***, 3 
                 
                   Homo sapiens 
                 
                 38,227 
                 22-Nov-98 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                   
                   
                 GB_HTG2: AC005079_1 
                 110000 
                 AC005079 
                   Homo sapiens  clone RG252P22, *** SEQUENCING IN PROGRESS ***, 3 
                 
                   Homo sapiens 
                 
                 38,227 
                 22-Nov-98 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                   
                   
                 GB_HTG2: AC005079_1 
                 110000 
                 AC005079 
                   Homo sapiens  clone RG252P22, *** SEQUENCING IN PROGRESS ***, 3 
                 
                   Homo sapiens 
                 
                 38,227 
                 22-Nov-98 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                 rxa00223 
                 1212 
                 GB_BA1: PPEA3NIF 
                 19771 
                 X99694 
                 Plasmid pEA3 nitrogen fixation genes. 
                 
                   Enterobacter agglomerans 
                 
                 48,826 
                 2-Aug-96 
               
               
                   
                   
                 GB_BA2: AF128444 
                 2477 
                 AF128444 
                   Rhodobacter capsulatus  molybdenum cofactor biosynthetic gene cluster, 
                 
                   Rhodobacter capsulatus 
                 
                 40,135 
                 22-MAR-1999 
               
               
                   
                   
                   
                   
                   
                 partial sequence. 
               
               
                   
                   
                 GB_HTG4: AC010111 
                 138938 
                 AC010111 
                   Drosophila melanogaster  chromosome 3L/70C1 clone RPCI98-9B18, *** 
                 
                   Drosophila melanogaster 
                 
                 39,527 
                 16-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 SEQUENCING IN PROGRESS ***, 64 unordered pieces. 
               
               
                 rxa00229 
                 803 
                 GB_BA2: AF124518 
                 1758 
                 AF124518 
                   Corynebacterium glutamicum  3-dehydroquinase (aroD) and shikimate 
                 
                   Corynebacterium glutamicum 
                 
                 98,237 
                 18-MAY-1999 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase (aroE) genes, complete cds. 
               
               
                   
                   
                 GB_PR3: AC004593 
                 150221 
                 AC004593 
                   Homo sapiens  PAC clone DJ0964C11 from 7p14-p15, complete sequence. 
                 
                   Homo sapiens 
                 
                 36,616 
                 18-Apr-98 
               
               
                   
                   
                 GB_HTG2: AC006907 
                 188972 
                 AC006907 
                   Caenorhabditis elegans  clone Y76B12, *** SEQUENCING IN PROGRESS ***, 
                 
                   Caenorhabditis elegans 
                 
                 37,095 
                 26-Feb-99 
               
               
                   
                   
                   
                   
                   
                 25 unordered pieces. 
               
               
                 rxa00241 
                 1626 
                 GB_BA1: CGLYSI 
                 4232 
                 X60312 
                   C. glutamicum  lysl gene for L-lysine permease. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 30-Jan-92 
               
               
                   
                   
                 GB_HTG1: PFMAL13P1 
                 192581 
                 AL049180 
                   Plasmodium falciparum  chromosome 13 strain 3D7, *** SEQUENCING IN 
                 
                   Plasmodium falciparum 
                 
                 34,947 
                 11-Aug-99 
               
               
                   
                   
                   
                   
                   
                 PROGRESS ***, in unordered pieces. 
               
               
                   
                   
                 GB_HTG1: PFMAL13P1 
                 192581 
                 AL049180 
                   Plasmodium falciparum  chromosome 13 strain 3D7, *** SEQUENCING IN 
                 
                   Plasmodium falciparum 
                 
                 34,947 
                 11-Aug-99 
               
               
                   
                   
                   
                   
                   
                 PROGRESS ***, in unordered pieces. 
               
               
                 rxa00262 
                 1197 
                 GB_IN2: EHU89655 
                 3219 
                 U89655 
                   Entamoeba histolytica  unconventional myosin IB mRNA, complete cds. 
                 
                   Entamoeba histolytica 
                 
                 36,496 
                 23-MAY-1997 
               
               
                   
                   
                 GB_IN2: EHU89655 
                 3219 
                 U89655 
                   Entamoeba histolytica  unconventional myosin IB mRNA, complete cds. 
                 
                   Entamoeba histolytica 
                 
                 37,544 
                 23-MAY-1997 
               
               
                 rxa00266 
                 531 
                 GB_RO: AF016190 
                 2939 
                 AF016190 
                   Mus musculus  connexin-36 (Cx36) gene, complete cds. 
                 
                   Mus musculus 
                 
                 41,856 
                 9-Feb-99 
               
               
                   
                   
                 EM_PAT: E09719 
                 3505 
                 E09719 
                 DNA encoding precursor protein of alkaline cellulase. 
                   Bacillus  sp. 
                 34,741 
                 08-OCT-1997 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 (Rel. 52, 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Created) 
               
               
                   
                   
                 GB_PAT: E02133 
                 3494 
                 E02133 
                 gDNA encoding alkaline cellulase. 
                   Bacillus  sp. 
                 34,741 
                 29-Sep-97 
               
               
                 rxa00278 
                 1155 
                 GB_IN1: CELK05F6 
                 36912 
                 AF040653 
                   Caenorhabditis elegans  cosmid K05F6. 
                 
                   Caenorhabditis elegans 
                 
                 36,943 
                 6-Jan-98 
               
               
                   
                   
                 GB_BA1: CGU43535 
                 2531 
                 U43535 
                   Corynebacterium glutamicum  multidrug resistance protein (cmr) gene, 
                 
                   Corynebacterium glutamicum 
                 
                 36,658 
                 9-Apr-97 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                 GB_RO: RNU30789 
                 3510 
                 U30789 
                   Rattus norvegicus  clone N27 mRNA. 
                 
                   Rattus norvegicus 
                 
                 38,190 
                 20-Aug-96 
               
               
                 rxa00295 
                 1125 
                 GB_BA2: CGU31281 
                 1614 
                 U31281 
                   Corynebacterium glutamicum  biotin synthase (bioB) gene, complete cds. 
                 
                   Corynebacterium glutamicum 
                 
                 99,111 
                 21-Nov-96 
               
               
                   
                   
                 GB_BA1: BRLBIOBA 
                 1647 
                 D14084 
                   Brevibacterium flavum  gene for biotin synthetase, complete cds. 
                 
                   Corynebacterium glutamicum 
                 
                 98,489 
                 3-Feb-99 
               
               
                   
                   
                 GB_PAT: E03937 
                 1005 
                 E03937 
                 DNA sequence encoding  Brevibacterium flavum  biotin-synthase. 
                 
                   Corynebacterium glutamicum 
                 
                 98,207 
                 29-Sep-97 
               
               
                 rxa00323 
                 1461 
                 GB_BA1: MTCY427 
                 38110 
                 Z70692 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 99/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 35,615 
                 24-Jun-99 
               
               
                   
                   
                 GB_BA1: MSGB32CS 
                 36404 
                 L78818 
                   Mycobacterium leprae  cosmid B32 DNA sequence. 
                 
                   Mycobacterium leprae 
                 
                 60,917 
                 15-Jun-96 
               
               
                   
                   
                 GB_BA1: MTCY427 
                 38110 
                 Z70692 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 99/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 44,606 
                 24-Jun-99 
               
               
                 rxa00324 
                 3258 
                 GB_BA1: MSGB32CS 
                 36404 
                 L78818 
                   Mycobacterium leprae  cosmid B32 DNA sequence. 
                 
                   Mycobacterium leprae 
                 
                 52,516 
                 15-Jun-96 
               
               
                   
                   
                 GB_BA1: MTCY427 
                 38110 
                 Z70692 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 99/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 38,079 
                 24-Jun-99 
               
               
                   
                   
                 GB_OM: BOVELA 
                 3242 
                 J02717 
                   Bovine elastin  a mRNA, complete cds. 
                 
                   Bos taurus 
                 
                 39,351 
                 27-Apr-93 
               
               
                 rxa00330 
                 1566 
                 GB_BA1: CGTHRC 
                 3120 
                 X56037 
                   Corynebacterium glutamicum  thrC gene for threonine synthase (EC 4.2.99.2). 
                 
                   Corynebacterium glutamicum 
                 
                 99,808 
                 17-Jun-97 
               
               
                   
                   
                 GB_PAT: I09078 
                 3146 
                 I09078 
                 Sequence 4 from Patent WO 8809819. 
                 Unknown. 
                 99,617 
                 02-DEC-1994 
               
               
                   
                   
                 GB_BA1: BLTHRESYN 
                 1892 
                 Z29563 
                   Brevibacterium lactofermentum ; ATCC 13869;; DNA (genomic);. 
                 
                   Corynebacterium glutamicum 
                 
                 99,170 
                 20-Sep-95 
               
               
                 rxa00335 
                 1554 
                 GB_BA1: CGGLNA 
                 3686 
                 Y13221 
                   Corynebacterium glutamicum  glnA gene. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 28-Aug-97 
               
               
                   
                   
                 GB_BA2: AF005635 
                 1690 
                 AF005635 
                   Corynebacterium glutamicum  glutamine synthetase (glnA) gene, complete cds. 
                 
                   Corynebacterium glutamicum 
                 
                 98,906 
                 14-Jun-99 
               
               
                   
                   
                 GB_BA1: MSGB27CS 
                 38793 
                 L78817 
                   Mycobacterium leprae  cosmid B27 DNA sequence. 
                 
                   Mycobacterium leprae 
                 
                 66,345 
                 15-Jun-96 
               
               
                 rxa00347 
                 891 
                 GB_EST27: AI455217 
                 624 
                 AI455217 
                 LD21828.3prime LD  Drosophila melanogaster  embryo pOT2  Drosophila   
                 
                   Drosophila melanogaster 
                 
                 34,510 
                 09-MAR-1999 
               
               
                   
                   
                   
                   
                   
                   melanogaster  cDNA clone LD21828 3prime, mRNA sequence. 
               
               
                   
                   
                 GB_BA2: SSU30252 
                 2891 
                 U30252 
                   Synechococcus  PCC7942 nucleoside diphosphate kinase and ORF2 protein 
                   Synechococcus  PCC7942 
                 37,084 
                 29-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 genes, complete cds, ORF1 protein gene, partial cds, and neutral site I for 
               
               
                   
                   
                   
                   
                   
                 vector use. 
               
               
                   
                   
                 GB_EST21: AA911262 
                 581 
                 AA911262 
                 oe75a02.s1 NCI_CGAP_Lu5  Homo sapiens  cDNA clone IMAGE: 1417418 3′ 
                 
                   Homo sapiens 
                 
                 37,500 
                 21-Apr-98 
               
               
                   
                   
                   
                   
                   
                 similar to gb: A18757 UROKINASE PLASMINOGEN ACTIVATOR SURFACE 
               
               
                   
                   
                   
                   
                   
                 RECEPTOR, GPI-ANCHORED (HUMAN);, mRNA sequence. 
               
               
                 rxa00351 
                 1578 
                 GB_BA1: MLU15187 
                 36138 
                 U15187 
                   Mycobacterium leprae  cosmid L296. 
                 
                   Mycobacterium leprae 
                 
                 52,972 
                 09-MAR-1995 
               
               
                   
                   
                 GB_IN2: AC004373 
                 72722 
                 AC004373 
                   Drosophila melanogaster  DNA sequence (P1 DS05273 (D80)), complete 
                 
                   Drosophila melanogaster 
                 
                 46,341 
                 17-Jul-98 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                   
                   
                 GB_IN2: AF145653 
                 3197 
                 AF145653 
                   Drosophila melanogaster  clone GH08860 BcDNA.GH08860 
                 
                   Drosophila melanogaster 
                 
                 49,471 
                 14-Jun-99 
               
               
                   
                   
                   
                   
                   
                 (BcDNA.GH08860) mRNA, complete cds. 
               
               
                 rxa00365 
                 727 
                 GB_BA1: AB024708 
                 8734 
                 AB024708 
                   Corynebacterium glutamicum  gltB and gltD genes for glutamine 2-oxoglutarate 
                 
                   Corynebacterium glutamicum 
                 
                 96,556 
                 13-MAR-1999 
               
               
                   
                   
                   
                   
                   
                 aminotransferase large and small subunits, complete cds. 
               
               
                   
                   
                 GB_BA1: MTCY1A6 
                 37751 
                 Z83864 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 159/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 39,496 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: SC3A3 
                 15901 
                 AL109849 
                   Streptomyces coelicolor  cosmid 3A3. 
                   Streptomyces coelicolor  A3(2) 
                 37,946 
                 16-Aug-99 
               
               
                 rxa00366 
                 480 
                 GB_BA1: AB024708 
                 8734 
                 AB024708 
                   Corynebacterium glutamicum  gltB and gltD genes for glutamine 2-oxoglutarate 
                 
                   Corynebacterium glutamicum 
                 
                 99,374 
                 13-MAR-1999 
               
               
                   
                   
                   
                   
                   
                 aminotransferase large and small subunits, complete cds. 
               
               
                   
                   
                 GB_BA1: MTCY1A6 
                 37751 
                 Z83864 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 159/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 41,333 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: SC3A3 
                 15901 
                 AL109849 
                   Streptomyces coelicolor  cosmid 3A3. 
                   Streptomyces coelicolor  A3(2) 
                 37,554 
                 16-Aug-99 
               
               
                 rxa00367 
                 4653 
                 GB_BA1: AB024708 
                 8734 
                 AB024708 
                   Corynebacterium glutamicum  gltB and gltD genes for glutamine 2- 
                 
                   Corynebacterium glutamicum 
                 
                 99,312 
                 13-MAR-1999 
               
               
                   
                   
                   
                   
                   
                 oxoglutarate aminotransferase large and small subunits, complete cds. 
               
               
                   
                   
                 GB_BA1: MTCY1A6 
                 37751 
                 Z83864 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 159/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 36,971 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: SC3A3 
                 15901 
                 AL109849 
                   Streptomyces coelicolor  cosmid 3A3. 
                   Streptomyces coelicolor  A3(2) 
                 37,905 
                 16-Aug-99 
               
               
                 rxa00371 
                 1917 
                 GB_VI: SBVORFS 
                 7568 
                 M89923 
                 Sugarcane bacilliform virus ORF 1, 2, and 3 DNA, complete cds. 
                 Sugarcane bacilliform virus 
                 35,843 
                 12-Jun-93 
               
               
                   
                   
                 GB_EST37: AI967505 
                 380 
                 AI967505 
                 Ljirnpest03-215-c10 Ljirnp Lambda HybriZap two-hybrid library  Lotus japonicus   
                 
                   Lotus japonicus 
                 
                 42,593 
                 24-Aug-99 
               
               
                   
                   
                   
                   
                   
                 cDNA clone LP215-03-c10 5′ similar to 60S ribosomal protein L39, mRNA 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                   
                   
                 GB_IN1: CELK09H9 
                 37881 
                 AF043700 
                   Caenorhabditis elegans  cosmid K09H9. 
                 
                   Caenorhabditis elegans 
                 
                 34,295 
                 22-Jan-98 
               
               
                 rxa00377 
                 1245 
                 GB_BA1: CCU13664 
                 1678 
                 U13664 
                   Caulobacter crescentus  uroporphyrinogen decarboxylase homolog (hemE) 
                 
                   Caulobacter crescentus 
                 
                 36,832 
                 24-MAR-1995 
               
               
                   
                   
                   
                   
                   
                 gene, partial cds. 
               
               
                   
                   
                 GB_PL1: ANSDGENE 
                 1299 
                 Y08866 
                   A. nidulans  sD gene. 
                 
                   Emericella nidulans 
                 
                 39,603 
                 17-OCT-1996 
               
               
                   
                   
                 GB_GSS4: AQ730303 
                 483 
                 AQ730303 
                 HS_5505_B1_C04_T7A RPCI-11 Human Male BAC Library  Homo sapiens   
                 
                   Homo sapiens 
                 
                 36,728 
                 15-Jul-99 
               
               
                   
                   
                   
                   
                   
                 genomic clone Plate = 1081 Col = 7 Row = F, genomic survey sequence. 
               
               
                 rxa00382 
                 1425 
                 GB_BA1: PAHEML 
                 4444 
                 X82072 
                   P. aeruginosa  hemL gene. 
                 
                   Pseudomonas aeruginosa 
                 
                 54,175 
                 18-DEC-1995 
               
               
                   
                   
                 GB_BA1: MTY25D10 
                 40838 
                 Z95558 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 28/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 61,143 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MSGY224 
                 40051 
                 AD000004 
                   Mycobacterium tuberculosis  sequence from clone y224. 
                 
                   Mycobacterium tuberculosis 
                 
                 61,143 
                 03-DEC-1996 
               
               
                 rxa00383 
                 1467 
                 GB_BA1: MLCB1222 
                 34714 
                 AL049491 
                   Mycobacterium leprae  cosmid B1222. 
                 
                   Mycobacterium leprae 
                 
                 43,981 
                 27-Aug-99 
               
               
                   
                   
                 GB_HTG2: AC006269 
                 167171 
                 AC006269 
                   Homo sapiens  chromosome 17 clone hRPK.515_E_23 map 17, *** 
                 
                   Homo sapiens 
                 
                 35,444 
                 10-Jun-99 
               
               
                   
                   
                   
                   
                   
                 SEQUENCING IN PROGRESS ***, 2 ordered pieces. 
               
               
                   
                   
                 GB_HTG2: AC007638 
                 178053 
                 AC007638 
                   Homo sapiens  chromosome 17 clone hRPK.515_O_17 map 17, *** 
                 
                   Homo sapiens 
                 
                 34,821 
                 22-MAY-1999 
               
               
                   
                   
                   
                   
                   
                 SEQUENCING IN PROGRESS ***, 8 unordered pieces. 
               
               
                 rxa00391 
                 843 
                 GB_EST38: AW017053 
                 613 
                 AW017053 
                 EST272398  Schistosoma mansoni  male, Phil LoVerde/Joe Merrick 
                 
                   Schistosoma mansoni 
                 
                 40,472 
                 10-Sep-99 
               
               
                   
                   
                   
                   
                   
                   Schistosoma mansoni  cDNA clone SMMAS14 5′ end, mRNA sequence. 
               
               
                   
                   
                 GB_PAT: AR065852 
                 32207 
                 AR065852 
                 Sequence 20 from patent U.S. Pat. No. 5849564. 
                 Unknown. 
                 38,586 
                 29-Sep-99 
               
               
                   
                   
                 GB_VI: AF148805 
                 28559 
                 AF148805 
                 Kaposi&#39;s sarcoma-associated herpesvirus ORF 68 gene, partial cds; and ORF 
                 Kaposi&#39;s sarcoma-associated 
                 38,509 
                 2-Aug-99 
               
               
                   
                   
                   
                   
                   
                 69, kaposin, v-FLIP, v-cyclin, latent nuclear antigen, ORF K14, v-GPCR, 
                 herpesvirus 
               
               
                   
                   
                   
                   
                   
                 putative phosphoribosylformylglycinamidine synthase, and LAMP 
               
               
                   
                   
                   
                   
                   
                 (LAMP) genes, complete cds. 
               
               
                 rxa00393 
                 1017 
                 GB_BA1: MTY25D10 
                 40838 
                 Z95558 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 28/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 36,308 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MSGY224 
                 40051 
                 AD000004 
                   Mycobacterium tuberculosis  sequence from clone y224. 
                 
                   Mycobacterium tuberculosis 
                 
                 39,282 
                 03-DEC-1996 
               
               
                   
                   
                 GB_BA1: MLB1306 
                 7762 
                 Y13803 
                   Mycobacterium leprae  cosmid B1306 DNA. 
                 
                   Mycobacterium leprae 
                 
                 39,228 
                 24-Jun-97 
               
               
                 rxa00402 
                 623 
                 GB_BA2: AF052652 
                 2096 
                 AF052652 
                   Corynebacterium glutamicum  homoserine O-acetyltransferase (metA) gene, 
                 
                   Corynebacterium glutamicum 
                 
                 99,672 
                 19-MAR-1998 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                 GB_BA2: AF109162 
                 4514 
                 AF109162 
                   Corynebacterium diphtheriae  heme uptake locus, complete sequence. 
                 
                   Corynebacterium diphtheriae 
                 
                 40,830 
                 8-Jun-99 
               
               
                   
                   
                 GB_BA2: AF092918 
                 20758 
                 AF092918 
                   Pseudomonas alcaligenes  outer membrane Xcp-secretion system gene 
                 
                   Pseudomonas alcaligenes 
                 
                 50,161 
                 06-DEC-1998 
               
               
                   
                   
                   
                   
                   
                 cluster. 
               
               
                 rxa00403 
                 1254 
                 GB_BA2: AF052652 
                 2096 
                 AF052652 
                   Corynebacterium glutamicum  homoserine O-acetyltransferase (metA) gene, 
                 
                   Corynebacterium glutamicum 
                 
                 99,920 
                 19-MAR-1998 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                 GB_BA1: MTV016 
                 53662 
                 AL021841 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 143/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 52,898 
                 23-Jun-99 
               
               
                   
                   
                 GB_EST23: AI111288 
                 750 
                 AI111288 
                 SWOvAMCAQ02A05SK  Onchocerca volvulus  adult male cDNA (SAW98MLW- 
                 
                   Onchocerca volvulus 
                 
                 37,565 
                 31-Aug-98 
               
               
                   
                   
                   
                   
                   
                 OvAM)  Onchocerca volvulus  cDNA clone SWOvAMCAQ02A05 5′, mRNA 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                 rxa00405 
                 613 
                 GB_BA1: MTV016 
                 53662 
                 AL021841 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 143/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 57,259 
                 23-Jun-99 
               
               
                   
                   
                 GB_PR4: AC005145 
                 143678 
                 AC005145 
                   Homo sapiens  Xp22-166-169 GSHB-523A23 (Genome Systems Human BAC 
                 
                   Homo sapiens 
                 
                 34,179 
                 08-DEC-1998 
               
               
                   
                   
                   
                   
                   
                 library) complete sequence. 
               
               
                   
                   
                 GB_BA1: MTV016 
                 53662 
                 AL021841 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 143/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 40,169 
                 23-Jun-99 
               
               
                 rxa00420 
                 1587 
                 GB_BA1: MTY13D12 
                 37085 
                 Z80343 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 156/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 62,031 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MSGY126 
                 37164 
                 AD000012 
                   Mycobacterium tuberculosis  sequence from clone y126. 
                 
                   Mycobacterium tuberculosis 
                 
                 61,902 
                 10-DEC-1996 
               
               
                   
                   
                 GB_BA1: MSGB971CS 
                 37566 
                 L78821 
                   Mycobacterium leprae  cosmid B971 DNA sequence. 
                 
                   Mycobacterium leprae 
                 
                 39,651 
                 15-Jun-96 
               
               
                 rxa00435 
                 1296 
                 GB_BA1: AFACBBTZ 
                 2760 
                 M68904 
                   Alcaligenes eutrophus  chromsomal transketolase (cbbTc) and 
                 
                   Ralstonia eutropha 
                 
                 38,677 
                 27-Jul-94 
               
               
                   
                   
                   
                   
                   
                 phosphoglycolate phosphatase (cbbZc) genes, complete cds. 
               
               
                   
                   
                 GB_HTG4: AC009541 
                 169583 
                 AC009541 
                   Homo sapiens  chromosome 7, *** SEQUENCING IN PROGRESS ***, 25 
                 
                   Homo sapiens 
                 
                 36,335 
                 12-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                   
                   
                 GB_HTG4: AC009541 
                 169583 
                 AC009541 
                   Homo sapiens  chromosome 7, *** SEQUENCING IN PROGRESS ***, 25 
                 
                   Homo sapiens 
                 
                 36,335 
                 12-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                 rxa00437 
                 579 
                 GB_PR4: AC005951 
                 155450 
                 AC005951 
                   Homo sapiens  chromosome 17, clone hRPK.372_K_20, complete sequence. 
                 
                   Homo sapiens 
                 
                 31,738 
                 18-Nov-98 
               
               
                   
                   
                 GB_BA1: SC2A11 
                 22789 
                 AL031184 
                   Streptomyces coelicolor  cosmid 2A11. 
                 
                   Streptomyces coelicolor 
                 
                 43,262 
                 5-Aug-98 
               
               
                   
                   
                 GB_PR4: AC005951 
                 155450 
                 AC005951 
                   Homo sapiens  chromosome 17, clone hRPK.372_K_20, complete sequence. 
                 
                   Homo sapiens 
                 
                 37,647 
                 18-Nov-98 
               
               
                 rxa00439 
                 591 
                 GB_BA1: MTV016 
                 53662 
                 AL021841 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 143/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 37,088 
                 23-Jun-99 
               
               
                   
                   
                 GB_PL2: AF167358 
                 1022 
                 AF167358 
                   Rumex acetosa  expansin (EXP3) gene, partial cds. 
                 
                   Rumex acetosa 
                 
                 46,538 
                 17-Aug-99 
               
               
                   
                   
                 GB_HTG3: AC009120 
                 269445 
                 AC009120 
                   Homo sapiens  chromosome 16 clone RPCI-11_484E3, *** SEQUENCING IN 
                 
                   Homo sapiens 
                 
                 43,276 
                 3-Aug-99 
               
               
                   
                   
                   
                   
                   
                 PROGRESS ***, 34 unordered pieces. 
               
               
                 rxa00440 
                 582 
                 GB_BA2: SKZ86111 
                 7860 
                 Z86111 
                   Streptomyces lividans  rpsP, trmD, rplS, sipW, sipX, sipY, sipZ, mutT genes 
                 
                   Streptomyces lividans 
                 
                 43,080 
                 27-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 and 4 open reading frames. 
               
               
                   
                   
                 GB_BA1: SC2E1 
                 38962 
                 AL023797 
                   Streptomyces coelicolor  cosmid 2E1. 
                 
                   Streptomyces coelicolor 
                 
                 42,931 
                 4-Jun-98 
               
               
                   
                   
                 GB_BA1: SC2E1 
                 38962 
                 AL023797 
                   Streptomyces coelicolor  cosmid 2E1. 
                 
                   Streptomyces coelicolor 
                 
                 36,702 
                 4-Jun-98 
               
               
                 rxa00441 
                 1287 
                 GB_PR2: HS173D1 
                 117338 
                 AL031984 
                 Human DNA sequence from clone 173D1 on chromosome 1p36.21-36.33. 
                 
                   Homo sapiens 
                 
                 38,027 
                 23-Nov-99 
               
               
                   
                   
                   
                   
                   
                 Contains ESTs, STSs and GSSs, complete sequence. 
               
               
                   
                   
                 GB_HTG2: HSDJ719K3 
                 267114 
                 AL109931 
                   Homo sapiens  chromosome X clone RP4-719K3 map q21.1-21.31, *** 
                 
                   Homo sapiens 
                 
                 34,521 
                 03-DEC-1999 
               
               
                   
                   
                   
                   
                   
                 SEQUENCING IN PROGRESS ***, in unordered pieces. 
               
               
                   
                   
                 GB_HTG2: HSDJ719K3 
                 267114 
                 AL109931 
                   Homo sapiens  chromosome X clone RP4-719K3 map q21.1-21.31, *** 
                 
                   Homo sapiens 
                 
                 34,521 
                 03-DEC-1999 
               
               
                   
                   
                   
                   
                   
                 SEQUENCING IN PROGRESS ***, in unordered pieces. 
               
               
                 rxa00446 
                 987 
                 GB_BA1: SCD78 
                 36224 
                 AL034355 
                   Streptomyces coelicolor  cosmid D78. 
                 
                   Streptomyces coelicolor 
                 
                 56,410 
                 26-Nov-98 
               
               
                   
                   
                 GB_HTG4: AC009367 
                 226055 
                 AC009367 
                   Drosophila melanogaster  chromosome 3L/76A2 clone RPCI98-48B15, *** 
                 
                   Drosophila melanogaster 
                 
                 34,959 
                 16-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 SEQUENCING IN PROGRESS ***, 44 unordered pieces. 
               
               
                   
                   
                 GB_HTG4: AC009367 
                 226055 
                 AC009367 
                   Drosophila melanogaster  chromosome 3L/76A2 clone RPCI98-48B15, *** 
                 
                   Drosophila melanogaster 
                 
                 34,959 
                 16-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 SEQUENCING IN PROGRESS ***, 44 unordered pieces. 
               
               
                 rxa00448 
                 1143 
                 GB_PR3: AC003670 
                 88945 
                 AC003670 
                   Homo sapiens  12q13.1 PAC RPCI1-130F5 (Roswell Park Cancer Institute 
                 
                   Homo sapiens 
                 
                 35,682 
                 9-Jun-98 
               
               
                   
                   
                   
                   
                   
                 Human PAC library) complete sequence. 
               
               
                   
                   
                 GB_HTG2: AF029367 
                 148676 
                 AF029367 
                   Homo sapiens  chromosome 12 clone RPCI-1 130F5 map 12q13.1, *** 
                 
                   Homo sapiens 
                 
                 31,373 
                 18-OCT-1997 
               
               
                   
                   
                   
                   
                   
                 SEQUENCING IN PROGRESS ***, 156 unordered pieces. 
               
               
                   
                   
                 GB_HTG2: AF029367 
                 148676 
                 AF029367 
                   Homo sapiens  chromosome 12 clone RPCI-1 130F5 map 12q13.1, *** 
                 
                   Homo sapiens 
                 
                 31,373 
                 18-OCT-1997 
               
               
                   
                   
                   
                   
                   
                 SEQUENCING IN PROGRESS ***, 156 unordered pieces. 
               
               
                 rxa00450 
                 424 
                 GB_HTG2: AC007824 
                 133361 
                 AC007824 
                   Drosophila melanogaster  chromosome 3 clone BACR02L16 (D715) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 40,000 
                 2-Aug-99 
               
               
                   
                   
                   
                   
                   
                 02.L.16 map 89E-90A strain y; cn bw sp, *** SEQUENCING IN PROGRESS 
               
               
                   
                   
                   
                   
                   
                 ***, 91 unordered pieces. 
               
               
                   
                   
                 GB_HTG2: AC007824 
                 133361 
                 AC007824 
                   Drosophila melanogaster  chromosome 3 clone BACR02L16 (D715) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 40,000 
                 2-Aug-99 
               
               
                   
                   
                   
                   
                   
                 02.L.16 map 89E-90A strain y; cn bw sp, *** SEQUENCING IN PROGRESS 
               
               
                   
                   
                   
                   
                   
                 ***, 91 unordered pieces. 
               
               
                   
                   
                 GB_EST35: AI818057 
                 412 
                 AI818057 
                 wk14a08.x1 NCI_CGAP_Lym12  Homo sapiens  cDNA clone IMAGE: 2412278 
                 
                   Homo sapiens 
                 
                 35,714 
                 24-Aug-99 
               
               
                   
                   
                   
                   
                   
                 3′ similar to gb: Y00764 UBIQUINOL-CYTOCHROME C REDUCTASE 11 KD 
               
               
                   
                   
                   
                   
                   
                 PROTEIN (HUMAN);, mRNA sequence. 
               
               
                 rxa00461 
                 975 
                 GB_BA1: MLCB1779 
                 43254 
                 Z98271 
                   Mycobacterium leprae  cosmid B1779. 
                 
                   Mycobacterium leprae 
                 
                 39,308 
                 8-Aug-97 
               
               
                   
                   
                 GB_IN1: DMC86E4 
                 29352 
                 AL021086 
                   Drosophila melanogaster  cosmid clone 86E4. 
                 
                   Drosophila melanogaster 
                 
                 37,487 
                 27-Apr-99 
               
               
                   
                   
                 GB_GSS15: AQ640325 
                 467 
                 AQ640325 
                 927P1-2H3.TP 927P1  Trypanosoma brucei  genomic clone 927P1-2H3, 
                 
                   Trypanosoma brucei 
                 
                 38,116 
                 8-Jul-99 
               
               
                   
                   
                   
                   
                   
                 genomic survey sequence. 
               
               
                 rxa00465 
               
               
                 rxa00487 
                 1692 
                 GB_BA1: BAGUAA 
                 3866 
                 Y10499 
                   B. ammoniagenes  guaA gene. 
                 
                   Corynebacterium 
                 
                 74,259 
                 8-Jan-98 
               
               
                   
                   
                   
                   
                   
                   
                 
                   ammoniagenes 
                 
               
               
                   
                   
                 GB_BA2: U00015 
                 42325 
                 U00015 
                   Mycobacterium leprae  cosmid B1620. 
                 
                   Mycobacterium leprae 
                 
                 37,248 
                 01-MAR-1994 
               
               
                   
                   
                 GB_BA1: MTCY78 
                 33818 
                 Z77165 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 145/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 39,725 
                 17-Jun-98 
               
               
                 rxa00488 
                 1641 
                 GB_BA1: MTCY78 
                 33818 
                 Z77165 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 145/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 39,451 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA2: U00015 
                 42325 
                 U00015 
                   Mycobacterium leprae  cosmid B1620. 
                 
                   Mycobacterium leprae 
                 
                 39,178 
                 01-MAR-1994 
               
               
                   
                   
                 GB_BA1: SCAJ10601 
                 4692 
                 AJ010601 
                   Streptomyces coelicolor  A3(2) DNA for whiD and whiK loci. 
                 
                   Streptomyces coelicolor 
                 
                 60,835 
                 17-Sep-98 
               
               
                 rxa00489 
                 1245 
                 GB_BA2: U00015 
                 42325 
                 U00015 
                   Mycobacterium leprae  cosmid B1620. 
                 
                   Mycobacterium leprae 
                 
                 38,041 
                 01-MAR-1994 
               
               
                   
                   
                 GB_HTG2: HS225E12 
                 126464 
                 AL031772 
                   Homo sapiens  chromosome 6 clone RP1-225E12 map q24, *** SEQUENCING 
                 
                   Homo sapiens 
                 
                 36,756 
                 03-DEC-1999 
               
               
                   
                   
                   
                   
                   
                 IN PROGRESS ***, in unordered pieces. 
               
               
                   
                   
                 GB_HTG2: HS225E12 
                 126464 
                 AL031772 
                   Homo sapiens  chromosome 6 clone RP1-225E12 map q24, *** SEQUENCING 
                 
                   Homo sapiens 
                 
                 36,756 
                 03-DEC-1999 
               
               
                   
                   
                   
                   
                   
                 IN PROGRESS ***, in unordered pieces. 
               
               
                 rxa00533 
                 1155 
                 GB_BA1: CGLYS 
                 2803 
                 X57226 
                   C. glutamicum  lysC-alpha, lysC-beta and asd genes for aspartokinase-alpha 
                 
                   Corynebacterium glutamicum 
                 
                 99,913 
                 17-Feb-97 
               
               
                   
                   
                   
                   
                   
                 and -beta subunits, and aspartate beta semialdehyde dehydrogenase, 
               
               
                   
                   
                   
                   
                   
                 respectively (EC 2.7.2.4; EC 1.2.1.11). 
               
               
                   
                   
                 GB_BA1: CGCYSCASD 
                 1591 
                 X82928 
                   C. glutamicum  aspartate-semialdehyde dehydrogenase gene. 
                 
                   Corynebacterium glutamicum 
                 
                 99,221 
                 17-Feb-97 
               
               
                   
                   
                 GB_PAT: A07546 
                 2112 
                 A07546 
                 Recombinant DNA fragment (Pstl-Xhol). 
                 synthetic construct 
                 99,391 
                 30-Jul-93 
               
               
                 rxa00534 
                 1386 
                 GB_BA1: CGLYS 
                 2803 
                 X57226 
                   C. glutamicum  lysC-alpha, lysC-beta and asd genes for aspartokinase-alpha 
                 
                   Corynebacterium glutamicum 
                 
                 99,856 
                 17-Feb-97 
               
               
                   
                   
                   
                   
                   
                 and -beta subunits, and aspartate beta semialdehyde dehydrogenase, 
               
               
                   
                   
                   
                   
                   
                 respectively (EC 2.7.2.4; EC 1.2.1.11). 
               
               
                   
                   
                 GB_BA1: CORASKD 
                 2957 
                 L16848 
                   Corynebacterium flavum  aspartokinase (ask), and aspartate-semialdehyde 
                 
                   Corynebacterium flavescens 
                 
                 98,701 
                 11-Jun-93 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase (asd) genes, complete cds. 
               
               
                   
                   
                 GB_PAT: E14514 
                 1643 
                 E14514 
                 DNA encoding  Brevibacterium  aspartokinase. 
                 
                   Corynebacterium glutamicum 
                 
                 98,773 
                 28-Jul-99 
               
               
                 rxa00536 
                 1494 
                 GB_BA1: CGLEUA 
                 3492 
                 X70959 
                   C. glutamicum  gene leuA for isopropylmalate synthase. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 10-Feb-99 
               
               
                   
                   
                 GB_BA1: MTV025 
                 121125 
                 AL022121 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 155/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 68,003 
                 24-Jun-99 
               
               
                   
                   
                 GB_BA1: MTU88526 
                 2412 
                 U88526 
                   Mycobacterium tuberculosis  putative alpha-isopropyl malate synthase (leuA) 
                 
                   Mycobacterium tuberculosis 
                 
                 68,185 
                 26-Feb-97 
               
               
                   
                   
                   
                   
                   
                 gene, complete cds. 
               
               
                 rxa00537 
                 2409 
                 GB_BA2: SCD25 
                 41622 
                 AL118514 
                   Streptomyces coelicolor  cosmid D25. 
                 
                   Streptomyces coelicolor A3(2) 
                 
                 63,187 
                 21-Sep-99 
               
               
                   
                   
                 GB_BA1: MTCY7H7A 
                 10451 
                 Z95618 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 39/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 62,401 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MTU34956 
                 2462 
                 U34956 
                   Mycobacterium tuberculosis  phosphoribosylformylglycinamidine synthase 
                 
                   Mycobacterium tuberculosis 
                 
                 62,205 
                 28-Jan-97 
               
               
                   
                   
                   
                   
                   
                 (purL) gene, complete cds. 
               
               
                 rxa00541 
                 792 
                 GB_PAT: I92052 
                 2115 
                 I92052 
                 Sequence 19 from patent U.S. Pat. No. 5726299. 
                 Unknown. 
                 98,359 
                 01-DEC-1998 
               
               
                   
                   
                 GB_BA1: MLCB5 
                 38109 
                 Z95151 
                   Mycobacterium leprae  cosmid B5. 
                 
                   Mycobacterium leprae 
                 
                 62,468 
                 24-Jun-97 
               
               
                   
                   
                 GB_BA1: MTCY369 
                 36850 
                 Z80226 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 36/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 60,814 
                 17-Jun-98 
               
               
                 rxa00558 
                 1470 
                 GB_BA1: BAPURF 
                 1885 
                 X91252 
                   B. ammoniagenes  purF gene. 
                 
                   Corynebacterium 
                 
                 66,095 
                 5-Jun-97 
               
               
                   
                   
                   
                   
                   
                   
                 
                   ammoniagenes 
                 
               
               
                   
                   
                 GB_BA1: MLU15182 
                 40123 
                 U15182 
                   Mycobacterium leprae  cosmid B2266. 
                 
                   Mycobacterium leprae 
                 
                 64,315 
                 09-MAR-1995 
               
               
                   
                   
                 GB_BA1: MTCY7H7A 
                 10451 
                 Z95618 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 39/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 64,863 
                 17-Jun-98 
               
               
                 rxa00579 
                 1983 
                 GB_PAT: AR016483 
                 2104 
                 AR016483 
                 Sequence 1 from patent U.S. Pat. No. 5776740. 
                 Unknown. 
                 98,810 
                 05-DEC-1998 
               
               
                   
                   
                 EM_PAT: E11273 
                 2104 
                 E11273 
                 DNA encoding serine hydroxymethyl transferase. 
                 
                   Corynebacterium glutamicum 
                 
                 98,810 
                 08-OCT-1997 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 (Rel. 52, 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Created) 
               
               
                   
                   
                 GB_PAT: E12594 
                 2104 
                 E12594 
                 DNA encoding serine hydroxymethyltransferase from  Brevibacterium flavum.   
                 
                   Corynebacterium glutamicum 
                 
                 98,810 
                 24-Jun-98 
               
               
                 rxa00580 
                 1425 
                 GB_PAT: E12594 
                 2104 
                 E12594 
                 DNA encoding serine hydroxymethyltransferase from  Brevibacterium flavum.   
                 
                   Corynebacterium glutamicum 
                 
                 99,368 
                 24-Jun-98 
               
               
                   
                   
                 GB_PAT: AR016483 
                 2104 
                 AR016483 
                 Sequence 1 from patent U.S. Pat. No. 5776740. 
                 Unknown. 
                 99,368 
                 05-DEC-1998 
               
               
                   
                   
                 EM_PAT: E11273 
                 2104 
                 E11273 
                 DNA encoding serine hydroxymethyl transferase. 
                 
                   Corynebacterium glutamicum 
                 
                 99,368 
                 08-OCT-1997 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 (Rel. 52, 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Created) 
               
               
                 rxa00581 
                 1092 
                 GB_PAT: E12594 
                 2104 
                 E12594 
                 DNA encoding serine hydroxymethyltransferase from  Brevibacterium flavum.   
                 
                   Corynebacterium glutamicum 
                 
                 37,071 
                 24-Jun-98 
               
               
                   
                   
                 EM_PAT: E11273 
                 2104 
                 E11273 
                 DNA encoding serine hydroxymethyl transferase. 
                 
                   Corynebacterium glutamicum 
                 
                 37,071 
                 08-OCT-1997 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 (Rel. 52, 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Created) 
               
               
                   
                   
                 GB_PAT: AR016483 
                 2104 
                 AR016483 
                 Sequence 1 from patent U.S. Pat. No. 5776740. 
                 Unknown. 
                 37,071 
                 05-DEC-1998 
               
               
                 rxa00584 
                 1248 
                 GB_BA1: CORAHPS 
                 2570 
                 L07603 
                   Corynebacterium glutamicum  3-deoxy-D-arabinoheptulosonate-7-phosphate 
                 
                   Corynebacterium glutamicum 
                 
                 98,236 
                 26-Apr-93 
               
               
                   
                   
                   
                   
                   
                 synthase gene, complete cds. 
               
               
                   
                   
                 GB_BA1: AOPCZA361 
                 37941 
                 AJ223998 
                   Amycolatopsis orientalis  cosmid PCZA361. 
                 
                   Amycolatopsis orientalis 
                 
                 54,553 
                 29-MAR-1999 
               
               
                   
                   
                 GB_BA1: D90714 
                 14358 
                 D90714 
                   Escherichia coli  genomic DNA. (16.8-17.1 min). 
                 
                   Escherichia coli 
                 
                 53,312 
                 7-Feb-99 
               
               
                 rxa00618 
                 1230 
                 GB_EST19: AA802737 
                 280 
                 AA802737 
                 GM06236.5prime GM  Drosophila melanogaster  ovary BlueScript  Drosophila   
                 
                   Drosophila melanogaster 
                 
                 39,928 
                 25-Nov-98 
               
               
                   
                   
                   
                   
                   
                   melanogaster  cDNA clone GM06236 5prime, mRNA sequence. 
               
               
                   
                   
                 GB_EST28: AI534381 
                 581 
                 AI534381 
                 SD07186.5prime SD  Drosophila melanogaster  Schneider L2 cell culture pOT2 
                 
                   Drosophila melanogaster 
                 
                 41,136 
                 18-MAR-1999 
               
               
                   
                   
                   
                   
                   
                   Drosophila melanogaster  cDNA clone SD07186 5prime similar to X89858: Ani 
               
               
                   
                   
                   
                   
                   
                 FBgn001f1558 PID: g927407 SPTREMBL: Q24240, mRNA sequence. 
               
               
                   
                   
                 GB_IN1: DMANILLIN 
                 4029 
                 X89858 
                   D. melanogaster  mRNA for anillin protein. 
                 
                   Drosophila melanogaster 
                 
                 34,398 
                 8-Nov-95 
               
               
                 rxa00619 
                 1551 
                 GB_BA1: MTCY369 
                 36850 
                 Z80226 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 36/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 62,776 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MLCB5 
                 38109 
                 Z95151 
                   Mycobacterium leprae  cosmid B5. 
                 
                   Mycobacterium leprae 
                 
                 61,831 
                 24-Jun-97 
               
               
                   
                   
                 GB_PAT: A60305 
                 1845 
                 A60305 
                 Sequence 5 from Patent WO9708323. 
                 unidentified 
                 61,785 
                 06-MAR-1998 
               
               
                 rxa00620 
                 1014 
                 GB_PL2: AF063247 
                 1450 
                 AF063247 
                   Pneumocystis carinii  f. sp.  ratti  enolase mRNA, complete cds. 
                   Pneumocystis carinii  f. sp.  ratti   
                 41,060 
                 5-Jan-99 
               
               
                   
                   
                 GB_BA1: STMAPP 
                 2069 
                 M91546 
                   Streptomyces lividans  aminopeptidase P (PepP) gene, complete cds. 
                 
                   Streptomyces lividans 
                 
                 37,126 
                 12-Jun-93 
               
               
                   
                   
                 GB_HTG3: AC008763 
                 214575 
                 AC008763 
                   Homo sapiens  chromosome 19 clone CITB-E1_3214H19, *** SEQUENCING 
                 
                   Homo sapiens 
                 
                 40,020 
                 3-Aug-99 
               
               
                   
                   
                   
                   
                   
                 IN PROGRESS ***, 21 unordered pieces. 
               
               
                 rxa00624 
                 810 
                 GB_IN1: CEY41E3 
                 150641 
                 Z95559 
                   Caenorhabditis elegans  cosmid Y41E3, complete sequence. 
                 
                   Caenorhabditis elegans 
                 
                 36,986 
                 2-Sep-99 
               
               
                   
                   
                 GB_EST13: AA362167 
                 372 
                 AA362167 
                 EST71561 Macrophage I  Homo sapiens  cDNA 5′ end, mRNA sequence. 
                 
                   Homo sapiens 
                 
                 38,378 
                 21-Apr-97 
               
               
                   
                   
                 GB_IN1: CEY41E3 
                 150641 
                 Z95559 
                   Caenorhabditis elegans  cosmid Y41E3, complete sequence. 
                 
                   Caenorhabditis elegans 
                 
                 37,694 
                 2-Sep-99 
               
               
                 rxa00626 
                 1386 
                 GB_BA1: MTCY369 
                 36850 
                 Z80226 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 36/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 57,971 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MLCB5 
                 38109 
                 Z95151 
                   Mycobacterium leprae  cosmid B5. 
                 
                   Mycobacterium leprae 
                 
                 58,806 
                 24-Jun-97 
               
               
                   
                   
                 GB_BA1: MLU15187 
                 36138 
                 U15187 
                   Mycobacterium leprae  cosmid L296. 
                 
                   Mycobacterium leprae 
                 
                 38,007 
                 09-MAR-1995 
               
               
                 rxa00632 
                 795 
                 GB_BA1: BRLBIOAD 
                 2272 
                 D14083 
                   Brevibacterium flavum  genes for 7,8-diaminopelargonic acid aminotransferase 
                 
                   Corynebacterium glutamicum 
                 
                 97,358 
                 3-Feb-99 
               
               
                   
                   
                   
                   
                   
                 and dethiobiotin synthetase, complete cds. 
               
               
                   
                   
                 GB_PAT: E04041 
                 675 
                 E04041 
                 DNA sequence coding for desthiobiotinsynthetase. 
                 
                   Corynebacterium glutamicum 
                 
                 98,074 
                 29-Sep-97 
               
               
                   
                   
                 GB_PAT: E04040 
                 1272 
                 E04040 
                 DNA sequence coding for diamino pelargonic acid aminotransferase. 
                 
                   Corynebacterium glutamicum 
                 
                 93,814 
                 29-Sep-97 
               
               
                 rxa00633 
                 1392 
                 GB_BA1: BRLBIOAD 
                 2272 
                 D14083 
                   Brevibacterium flavum  genes for 7,8-diaminopelargonic acid aminotransferase 
                 
                   Corynebacterium glutamicum 
                 
                 95,690 
                 3-Feb-99 
               
               
                   
                   
                   
                   
                   
                 and dethiobiotin synthetase, complete cds. 
               
               
                   
                   
                 GB_PAT: E04040 
                 1272 
                 E04040 
                 DNA sequence coding for diamino pelargonic acid aminotransferase. 
                 
                   Corynebacterium glutamicum 
                 
                 95,755 
                 29-Sep-97 
               
               
                   
                   
                 GB_BA2: EHU38519 
                 1290 
                 U38519 
                   Erwinia herbicola  adenosylmethionine-8-amino-7-oxononanoate transaminase 
                 
                   Erwinia herbicola 
                 
                 55,564 
                 4-Nov-96 
               
               
                   
                   
                   
                   
                   
                 (bioA) gene, complete cds. 
               
               
                 rxa00688 
                 666 
                 GB_BA1: MTV041 
                 28826 
                 AL021958 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 35/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 60,030 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: BRLSECY 
                 1516 
                 D14162 
                   Brevibacterium flavum  gene for SecY protein (complete cds) and gene or 
                 
                   Corynebacterium glutamicum 
                 
                 99,563 
                 3-Feb-99 
               
               
                   
                   
                   
                   
                   
                 adenylate kinase (partial cds). 
               
               
                   
                   
                 GB_BA2: MBU77912 
                 7163 
                 U77912 
                   Mycobacterium bovis  MBE50a gene, partial cds; and MBE50b, MBE50c, 
                 
                   Mycobacterium bovis 
                 
                 60,030 
                 27-Jan-99 
               
               
                   
                   
                   
                   
                   
                 preprotein translocase SecY subunit (secY), adenylate kinase (adk), 
               
               
                   
                   
                   
                   
                   
                 methionine aminopeptidase (map), RNA polymerase ECF sigma factor 
               
               
                   
                   
                   
                   
                   
                 (sigE50), MBE50d, and MBE50e genes, complete cds. 
               
               
                 rxa00708 
                 930 
                 GB_BA2: AF157493 
                 25454 
                 AF157493 
                   Zymomonas mobilis  ZM4 fosmid clone 42D7, complete sequence. 
                 
                   Zymomonas mobilis 
                 
                 39,116 
                 5-Jul-99 
               
               
                   
                   
                 GB_PAT: I00836 
                 1853 
                 I00836 
                 Sequence 1 from Patent U.S. Pat. No. 4758514. 
                 Unknown. 
                 47,419 
                 21-MAY-1993 
               
               
                   
                   
                 GB_PAT: E00311 
                 1853 
                 E00311 
                 DNA coding of 2,5-diketogluconic acid reductase. 
                 unidentified 
                 47,419 
                 29-Sep-97 
               
               
                 rxa00717 
                 1083 
                 GB_PAT: I78753 
                 1187 
                 I78753 
                 Sequence 9 from patent U.S. Pat. No. 5693781. 
                 Unknown. 
                 37,814 
                 3-Apr-98 
               
               
                   
                   
                 GB_PAT: I92042 
                 1187 
                 I92042 
                 Sequence 9 from patent U.S. Pat. No. 5726299. 
                 Unknown. 
                 37,814 
                 01-DEC-1998 
               
               
                   
                   
                 GB_BA1: MTCI125 
                 37432 
                 Z98268 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 76/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 50,647 
                 17-Jun-98 
               
               
                 rxa00718 
                 831 
                 GB_BA1: MTCI125 
                 37432 
                 Z98268 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 76/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 55,228 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MTCI125 
                 37432 
                 Z98268 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 76/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 40,300 
                 17-Jun-98 
               
               
                   
                   
                 GB_GSS12: AQ420755 
                 671 
                 AQ420755 
                 RPCI-11-168G18.TJ RPCI-11  Homo sapiens  genomic clone RPCI-11- 
                 
                   Homo sapiens 
                 
                 35,750 
                 23-MAR-1999 
               
               
                   
                   
                   
                   
                   
                 168G18, genomic survey sequence. 
               
               
                 rxa00727 
                 1035 
                 GB_HTG3: AC008332 
                 118545 
                 AC008332 
                   Drosophila melanogaster  chromosome 2 clone BACR48D10 (D867) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 40,634 
                 6-Aug-99 
               
               
                   
                   
                   
                   
                   
                 48.D.10 map 34A-34A strain y; cn bw sp, *** SEQUENCING IN PROGRESS 
               
               
                   
                   
                   
                   
                   
                 ***, 78 unordered pieces. 
               
               
                   
                   
                 GB_HTG3: AC008332 
                 118545 
                 AC008332 
                   Drosophila melanogaster  chromosome 2 clone BACR48D10 (D867) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 40,634 
                 6-Aug-99 
               
               
                   
                   
                   
                   
                   
                 48.D.10 map 34A-34A strain y; cn bw sp, *** SEQUENCING IN 
               
               
                   
                   
                   
                   
                   
                 PROGRESS***, 78 unordered pieces. 
               
               
                   
                   
                 GB_HTG3: AC008332 
                 118545 
                 AC008332 
                   Drosophila melanogaster  chromosome 2 clone BACR48D10 (D867) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 33,888 
                 6-Aug-99 
               
               
                   
                   
                   
                   
                   
                 48.D.10 map 34A-34A strain y; cn bw sp, *** SEQUENCING IN 
               
               
                   
                   
                   
                   
                   
                 PROGRESS***, 78 unordered pieces. 
               
               
                 rxa00766 
                 966 
                 GB_HTG2: AC006789 
                 83823 
                 AC006789 
                   Caenorhabditis elegans  clone Y49F6, *** SEQUENCING IN PROGRESS ***, 2 
                 
                   Caenorhabditis elegans 
                 
                 36,737 
                 25-Feb-99 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                   
                   
                 GB_HTG2: AC006789 
                 83823 
                 AC006789 
                   Caenorhabditis elegans  clone Y49F6, *** SEQUENCING IN PROGRESS ***, 2 
                 
                   Caenorhabditis elegans 
                 
                 36,737 
                 25-Feb-99 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                   
                   
                 GB_BA1: D90810 
                 20476 
                 D90810 
                   E. coli  genomic DNA, Kohara clone #319(37.4-37.8 min.). 
                 
                   Escherichia coli 
                 
                 36,526 
                 29-MAY-1997 
               
               
                 rxa00770 
                 1293 
                 GB_BA1: MTV043 
                 68848 
                 AL022004 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 40/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 66,193 
                 24-Jun-99 
               
               
                   
                   
                 GB_BA1: MLU15182 
                 40123 
                 U15182 
                   Mycobacterium leprae  cosmid B2266. 
                 
                   Mycobacterium leprae 
                 
                 61,443 
                 09-MAR-1995 
               
               
                   
                   
                 GB_BA2: SCD25 
                 41622 
                 AL118514 
                   Streptomyces coelicolor  cosmid D25. 
                 
                   Streptomyces coelicolor A3(2) 
                 
                 59,938 
                 21-Sep-99 
               
               
                 rxa00779 
                 1056 
                 GB_HTG1: CER08A5 
                 51920 
                 Z82281 
                   Caenorhabditis elegans  chromosome V clone R08A5, *** SEQUENCING IN 
                 
                   Caenorhabditis elegans 
                 
                 64,896 
                 14-OCT-1998 
               
               
                   
                   
                   
                   
                   
                 PROGRESS ***, in unordered pieces. 
               
               
                   
                   
                 GB_HTG1: CER08A5 
                 51920 
                 Z82281 
                   Caenorhabditis elegans  chromosome V clone R08A5, *** SEQUENCING IN 
                 
                   Caenorhabditis elegans 
                 
                 64,896 
                 14-OCT-1998 
               
               
                   
                   
                   
                   
                   
                 PROGRESS ***, in unordered pieces. 
               
               
                   
                   
                 GB_PL2: AF078693 
                 1492 
                 AF078693 
                   Chlamydomonas reinhardtii  putative O-acetylserine(thiol)lyase precursor 
                 
                   Chlamydomonas reinhardtii 
                 
                 57,970 
                 3-Nov-99 
               
               
                   
                   
                   
                   
                   
                 (Crcys-1A) mRNA, nuclear gene encoding organellar protein, complete cds. 
               
               
                 rxa00780 
                 669 
                 GB_BA1: MTCY98 
                 31225 
                 Z83860 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 103/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 54,410 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: AVINIFREG 
                 7099 
                 M60090 
                   Azotobacter chroococcum  nifU, nifS, nifV, nifP, nifW, nifZ and nifM genes, 
                 
                   Azotobacter chroococcum 
                 
                 51,729 
                 26-Apr-93 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                 GB_BA2: AF001780 
                 6701 
                 AF001780 
                 Cyanothece PCC 8801 NifP (nifP), nitrogenase (nifB), FdxN (fdxN), NifS (nifS) 
                 
                   Cyanothece PCC8801 
                 
                 36,309 
                 08-MAR-1999 
               
               
                   
                   
                   
                   
                   
                 and NifU (nifU) genes, complete cds, and NifH (nifH) gene, partial cds. 
               
               
                 rxa00838 
                 1023 
                 GB_EST1: Z30506 
                 329 
                 Z30506 
                 ATTS2430 AC16H  Arabidopsis thaliana  cDNA clone TAI306 3′, mRNA 
                 
                   Arabidopsis thaliana 
                 
                 44,308 
                 11-MAR-1994 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                   
                   
                 GB_PL2: AC006258 
                 110469 
                 AC006258 
                   Arabidopsis thaliana  BAC F18G18 from chromosome V near 60.5 cM, 
                 
                   Arabidopsis thaliana 
                 
                 35,571 
                 28-DEC-1998 
               
               
                   
                   
                   
                   
                   
                 complete sequence. 
               
               
                   
                   
                 GB_EST37: AI998439 
                 455 
                 AI998439 
                 701545695  A. thaliana , Columbia Col-0, rosette-2  Arabidopsis thaliana  cDNA 
                 
                   Arabidopsis thaliana 
                 
                 36,044 
                 8-Sep-99 
               
               
                   
                   
                   
                   
                   
                 clone 701545695, mRNA sequence. 
               
               
                 rxa00863 
                 867 
                 GB_BA1: BLDAPAB 
                 3572 
                 Z21502 
                   B. lactofermentum  dapA and dapB genes for dihydrodipicolinate synthase and 
                 
                   Corynebacterium glutamicum 
                 
                 99,539 
                 16-Aug-93 
               
               
                   
                   
                   
                   
                   
                 dihydrodipicolinate reductase. 
               
               
                   
                   
                 GB_PAT: E16749 
                 2001 
                 E16749 
                 gDNA encoding dihydrodipicolinate synthase (DDPS). 
                 
                   Corynebacterium glutamicum 
                 
                 99,539 
                 28-Jul-99 
               
               
                   
                   
                 GB_PAT: E14520 
                 2001 
                 E14520 
                 DNA encoding  Brevibacterium  dihydrodipicolinic acid synthase. 
                 
                   Corynebacterium glutamicum 
                 
                 99,539 
                 28-Jul-99 
               
               
                 rxa00864 
                 873 
                 GB_BA1: BLDAPAB 
                 3572 
                 Z21502 
                   B. lactofermentum  dapA and dapB genes for dihydrodipicolinate synthase and 
                 
                   Corynebacterium glutamicum 
                 
                 99,885 
                 16-Aug-93 
               
               
                   
                   
                   
                   
                   
                 dihydrodipicolinate reductase. 
               
               
                   
                   
                 GB_BA1: CGDAPB 
                 1902 
                 X67737 
                   C. glutamicum  dapB gene for dihydrodipicolinate reductase. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 1-Apr-93 
               
               
                   
                   
                 GB_PAT: E14520 
                 2001 
                 E14520 
                 DNA encoding  Brevibacterium  dihydrodipicolinic acid synthase. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 28-Jul-99 
               
               
                 rxa00865 
                 1026 
                 GB_BA1: BLDAPAB 
                 3572 
                 Z21502 
                   B. lactofermentum  dapA and dapB genes for dihydrodipicolinate synthase and 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 16-Aug-93 
               
               
                   
                   
                   
                   
                   
                 dihydrodipicolinate reductase. 
               
               
                   
                   
                 GB_PAT: E16752 
                 1411 
                 E16752 
                 gDNA encoding dihydrodipicolinate reductase (DDPR). 
                 
                   Corynebacterium glutamicum 
                 
                 99,805 
                 28-Jul-99 
               
               
                   
                   
                 GB_PAT: AR038113 
                 1411 
                 AR038113 
                 Sequence 18 from patent U.S. Pat. No. 5804414. 
                 Unknown. 
                 99,805 
                 29-Sep-99 
               
               
                 rxa00867 
                 650 
                 GB_BA1: MTV002 
                 56414 
                 AL008967 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 122/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 39,179 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MLCB22 
                 40281 
                 Z98741 
                   Mycobacterium leprae  cosmid B22. 
                 
                   Mycobacterium leprae 
                 
                 39,482 
                 22-Aug-97 
               
               
                   
                   
                 GB_BA1: SAU19858 
                 2838 
                 U19858 
                   Streptomyces antibioticus  guanosine pentaphosphate synthetase (gpsl) gene, 
                 
                   Streptomyces antibioticus 
                 
                 69,706 
                 25-OCT-1996 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                 rxa00873 
                 779 
                 GB_BA1: SCO001206 
                 9184 
                 AJ001206 
                   Streptomyces coelicolor  A3(2), glycogen metabolism cluster II. 
                 
                   Streptomyces coelicolor 
                 
                 63,415 
                 29-MAR-1999 
               
               
                   
                   
                 GB_BA1: SCO001205 
                 9589 
                 AJ001205 
                   Streptomyces coelicolor  A3(2) glycogen metabolism clusterI 
                 
                   Streptomyces coelicolor 
                 
                 61,617 
                 29-MAR-1999 
               
               
                   
                   
                 GB_BA1: D78198 
                 2304 
                 D78198 
                   Pimelobacter  sp. DNA for trehalose synthase, complete cds. 
                   Pimelobacter  sp. 
                 60,594 
                 5-Feb-99 
               
               
                 rxa00884 
                 1263 
                 GB_BA1: MTCY253 
                 41230 
                 Z81368 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 106/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 37,785 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MSGY222 
                 41156 
                 AD000010 
                   Mycobacterium tuberculosis  sequence from clone y222. 
                 
                   Mycobacterium tuberculosis 
                 
                 38,006 
                 03-DEC-1996 
               
               
                   
                   
                 GB_GSS15: AQ654600 
                 468 
                 AQ654600 
                 Sheared DNA-1O14. TF Sheared DNA Trypanosoma brucei genomic clone 
                 
                   Trypanosoma brucei 
                 
                 33,974 
                 22-Jun-99 
               
               
                   
                   
                   
                   
                   
                 Sheared DNA-1O14, genomic survey sequence. 
               
               
                 rxa00891 
                 1102 
                 GB_BA1: MTCI418B 
                 11700 
                 Z96071 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 7/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 63,297 
                 18-Jun-98 
               
               
                   
                   
                 GB_BA1: SCO001206 
                 9184 
                 AJ001206 
                   Streptomyces coelicolor  A3(2), glycogen metabolism cluster II. 
                 
                   Streptomyces coelicolor 
                 
                 61,965 
                 29-MAR-1999 
               
               
                   
                   
                 GB_BA1: SCO001205 
                 9589 
                 AJ001205 
                   Streptomyces coelicolor  A3(2), glycogen metabolism clusterI. 
                 
                   Streptomyces coelicolor 
                 
                 61,727 
                 29-MAR-1999 
               
               
                 rxa00952 
                 963 
                 EM_PAT: E10963 
                 3118 
                 E10963 
                 gDNA encoding tryptophan synthase. 
                 
                   Corynebacterium glutamicum 
                 
                 99,688 
                 08-OCT-1997 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 (Rel. 52, 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Created) 
               
               
                   
                   
                 GB_BA1: BLTRP 
                 7725 
                 X04960 
                   Brevibacterium lactofermentum  tryptophan operon. 
                 
                   Corynebacterium glutamicum 
                 
                 98,847 
                 10-Feb-99 
               
               
                   
                   
                 GB_PAT: E01688 
                 7725 
                 E01688 
                 Genomic DNA of trp operon of  prepibacterium latophelmentamn . 
                 unidentified 
                 98,428 
                 29-Sep-97 
               
               
                 rxa00954 
                 644 
                 GB_PAT: E01375 
                 7726 
                 E01375 
                 DNA sequence of tryptophan operon. 
                 
                   Corynebacterium glutamicum 
                 
                 98,758 
                 29-Sep-97 
               
               
                   
                   
                 GB_PAT: E01688 
                 7725 
                 E01688 
                 Genomic DNA of trp operon of  prepibacterium latophelmentamn . 
                 unidentified 
                 98,758 
                 29-Sep-97 
               
               
                   
                   
                 GB_BA1: BLTRP 
                 7725 
                 X04960 
                   Brevibacterium lactofermentum  tryptophan operon. 
                 
                   Corynebacterium glutamicum 
                 
                 98,758 
                 10-Feb-99 
               
               
                 rxa00955 
                 1545 
                 GB_PAT: E01375 
                 7726 
                 E01375 
                 DNA sequence of tryptophan operon. 
                 
                   Corynebacterium glutamicum 
                 
                 98,372 
                 29-Sep-97 
               
               
                   
                   
                 GB_BA1: BLTRP 
                 7725 
                 X04960 
                   Brevibacterium lactofermentum  tryptophan operon. 
                 
                   Corynebacterium glutamicum 
                 
                 98,372 
                 10-Feb-99 
               
               
                   
                   
                 GB_PAT: E01688 
                 7725 
                 E01688 
                 Genomic DNA of trp operon of  prepibacterium latophelmentamn . 
                 unidentified 
                 98,242 
                 29-Sep-97 
               
               
                 rxa00956 
                 1237 
                 EM_PAT: E10963 
                 3118 
                 E10963 
                 gDNA encoding tryptophan synthase. 
                 
                   Corynebacterium glutamicum 
                 
                 98,949 
                 08-OCT-1997 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 (Rel. 52, 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Created) 
               
               
                   
                   
                 GB_BA1: BLTRP 
                 7725 
                 X04960 
                   Brevibacterium lactofermentum  tryptophan operon. 
                 
                   Corynebacterium glutamicum 
                 
                 99,107 
                 10-Feb-99 
               
               
                   
                   
                 GB_PAT: E01375 
                 7726 
                 E01375 
                 DNA sequence of tryptophan operon. 
                 
                   Corynebacterium glutamicum 
                 
                 98,945 
                 29-Sep-97 
               
               
                 rxa00957 
                 1677 
                 GB_BA1: BLTRP 
                 7725 
                 X04960 
                   Brevibacterium lactofermentum  tryptophan operon. 
                 
                   Corynebacterium glutamicum 
                 
                 99,165 
                 10-Feb-99 
               
               
                   
                   
                 GB_PAT: E01375 
                 7726 
                 E01375 
                 DNA sequence of tryptophan operon. 
                 
                   Corynebacterium glutamicum 
                 
                 98,927 
                 29-Sep-97 
               
               
                   
                   
                 GB_PAT: E01688 
                 7725 
                 E01688 
                 Genomic DNA of trp operon of  prepibacterium latophelmentamn . 
                 unidentified 
                 98,867 
                 29-Sep-97 
               
               
                 rxa00958 
                 747 
                 GB_BA1: BLTRP 
                 7725 
                 X04960 
                   Brevibacterium lactofermentum  tryptophan operon. 
                 
                   Corynebacterium glutamicum 
                 
                 98,792 
                 10-Feb-99 
               
               
                   
                   
                 GB_PAT: E01375 
                 7726 
                 E01375 
                 DNA sequence of tryptophan operon. 
                 
                   Corynebacterium glutamicum 
                 
                 98,792 
                 29-Sep-97 
               
               
                   
                   
                 GB_PAT: E01688 
                 7725 
                 E01688 
                 Genomic DNA of trp operon of  prepibacterium latophelmentamn . 
                 unidentified 
                 98,658 
                 29-Sep-97 
               
               
                 rxa00970 
                 1050 
                 GB_BA1: CGHOMTHR 
                 3685 
                 Y00546 
                   Corynebacterium glutamicum  hom-thrB genes for homoserine dehydrogenase 
                 
                   Corynebacterium glutamicum 
                 
                 99,905 
                 12-Sep-93 
               
               
                   
                   
                   
                   
                   
                 and homoserine kinase. 
               
               
                   
                   
                 GB_PAT: I09077 
                 3685 
                 I09077 
                 Sequence 1 from Patent WO 8809819. 
                 Unknown. 
                 99,810 
                 02-DEC-1994 
               
               
                   
                   
                 GB_PAT: E01358 
                 2615 
                 E01358 
                 DNA encoding for homoserine dehydrogenase(HDH)and homoserine 
                 
                   Corynebacterium glutamicum 
                 
                 97,524 
                 29-Sep-97 
               
               
                   
                   
                   
                   
                   
                 kinase(HK). 
               
               
                 rxa00972 
                 1458 
                 GB_PAT: E16755 
                 3579 
                 E16755 
                 gDNA encoding diaminopimelate decarboxylase (DDC) and arginyl-tRNA 
                 
                   Corynebacterium glutamicum 
                 
                 99,931 
                 28-Jul-99 
               
               
                   
                   
                   
                   
                   
                 synthase. 
               
               
                   
                   
                 GB_PAT: AR038110 
                 3579 
                 AR038110 
                 Sequence 15 from patent U.S. Pat. No. 5804414. 
                 Unknown. 
                 99,931 
                 29-Sep-99 
               
               
                   
                   
                 GB_PAT: E14508 
                 3579 
                 E14508 
                 DNA encoding  Brevibacterium  diaminopimelic acid decarboxylase and arginyl- 
                 
                   Corynebacterium glutamicum 
                 
                 99,931 
                 28-Jul-99 
               
               
                   
                   
                   
                   
                   
                 tRNA synthase. 
               
               
                 rxa00981 
                 753 
                 GB_OV: GGA245664 
                 512 
                 AJ245664 
                   Gallus gallus  partial mRNA for ATP-citrate lyase (ACL gene). 
                 
                   Gallus gallus 
                 
                 37,538 
                 28-Sep-99 
               
               
                   
                   
                 GB_PL2: AC007887 
                 159434 
                 AC007887 
                 Genomic sequence for  Arabidopsis thaliana  BAC F15O4 from chromosome I, 
                 
                   Arabidopsis thaliana 
                 
                 37,600 
                 04-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 complete sequence. 
               
               
                   
                   
                 GB_GSS1: CNS00RNW 
                 542 
                 AL087338 
                   Arabidopsis thaliana  genome survey sequence T7 end of BAC F14D7 of IGF 
                 
                   Arabidopsis thaliana 
                 
                 41,264 
                 28-Jun-99 
               
               
                   
                   
                   
                   
                   
                 library from strain Columbia of  Arabidopsis thaliana , genomic survey 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                 rxa00989 
                 1644 
                 GB_BA1: MTV008 
                 63033 
                 AL021246 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 108/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 40,773 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: SCVALSFP 
                 3619 
                 Y13070 
                   S. coelicolor  valS, fpgs, ndk genes. 
                 
                   Streptomyces coelicolor 
                 
                 58,119 
                 03-MAR-1998 
               
               
                   
                   
                 GB_BA1: MTV008 
                 63033 
                 AL021246 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 108/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 38,167 
                 17-Jun-98 
               
               
                 rxa00997 
                 705 
                 GB_BA2: CGU31225 
                 1817 
                 U31225 
                   Corynebacterium glutamicum  L-proline: NADP+ 5-oxidoreductase (proC) gene, 
                 
                   Corynebacterium glutamicum 
                 
                 40,841 
                 2-Aug-96 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                 GB_HTG1: CEY39C12 
                 282838 
                 AL009026 
                   Caenorhabditis elegans  chromosome IV clone Y39C12, *** SEQUENCING IN 
                 
                   Caenorhabditis elegans 
                 
                 36,416 
                 26-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 PROGRESS ***, in unordered pieces. 
               
               
                   
                   
                 GB_IN1: CEB0001 
                 39416 
                 Z69634 
                   Caenorhabditis elegans  cosmid B0001, complete sequence. 
                 
                   Caenorhabditis elegans 
                 
                 36,416 
                 2-Sep-99 
               
               
                 rxa01019 
                 1110 
                 GB_HTG2: AC005052 
                 144734 
                 AC005052 
                   Homo sapiens  clone RG038K21, *** SEQUENCING IN PROGRESS ***, 3 
                 
                   Homo sapiens 
                 
                 39,172 
                 12-Jun-98 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                   
                   
                 GB_HTG2: AC005052 
                 144734 
                 AC005052 
                   Homo sapiens  clone RG038K21, *** SEQUENCING IN PROGRESS ***, 3 
                 
                   Homo sapiens 
                 
                 39,172 
                 12-Jun-98 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                   
                   
                 GB_GSS9: AQ171808 
                 512 
                 AQ171808 
                 HS_3179_A1_G03_T7 CIT Approved Human Genomic Sperm Library D 
                 
                   Homo sapiens 
                 
                 34,661 
                 17-OCT-1998 
               
               
                   
                   
                   
                   
                   
                   Homo sapiens  genomic clone Plate = 3179 Col = 5 Row = M, 
               
               
                   
                   
                   
                   
                   
                 genomic survey sequence. 
               
               
                 rxa01026 
                 1782 
                 GB_BA1: SC1C2 
                 42210 
                 AL031124 
                   Streptomyces coelicolor  cosmid 1C2. 
                 
                   Streptomyces coelicolor 
                 
                 68,275 
                 15-Jan-99 
               
               
                   
                   
                 GB_BA1: ATLEUCD 
                 2982 
                 X84647 
                   A. teichomyceticus  leuC and leuD genes. 
                 
                   Actinoplanes teichomyceticus 
                 
                 65,935 
                 04-OCT-1995 
               
               
                   
                   
                 GB_BA1: MTV012 
                 70287 
                 AL021287 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 132/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 40,454 
                 23-Jun-99 
               
               
                 rxa01027 
                 1131 
                 GB_BA1: MLCB637 
                 44882 
                 Z99263 
                   Mycobacterium leprae  cosmid B637. 
                 
                   Mycobacterium leprae 
                 
                 38,636 
                 17-Sep-97 
               
               
                   
                   
                 GB_BA1: MTCY349 
                 43523 
                 Z83018 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 131/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 51,989 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: SPUNGMUTX 
                 1172 
                 Z21702 
                   S. pneumoniae  ung gene and mutX genes encoding uracil-DNA glycosylase 
                 
                   Streptococcus pneumoniae 
                 
                 38,088 
                 15-Jun-94 
               
               
                   
                   
                   
                   
                   
                 and 8-oxodGTP nucleoside triphosphatase. 
               
               
                 rxa01073 
                 954 
                 GB_BA1: BACOUTB 
                 1004 
                 M15811 
                   Bacillus subtilis  outB gene encoding a sporulation protein, complete cds. 
                 
                   Bacillus subtilis 
                 
                 53,723 
                 26-Apr-93 
               
               
                   
                   
                 GB_PR4: AC007938 
                 167237 
                 AC007938 
                   Homo sapiens  clone UWGC: djs201 from 7q31, complete sequence. 
                 
                   Homo sapiens 
                 
                 34,322 
                 1-Jul-99 
               
               
                   
                   
                 GB_PL2: ATAC006282 
                 92577 
                 AC006282 
                   Arabidopsis thaliana  chromosome II BAC F13K3 genomic sequence, complete 
                 
                   Arabidopsis thaliana 
                 
                 36,181 
                 13-MAR-1999 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                 rxa01079 
                 2226 
                 GB_BA2: AF112535 
                 4363 
                 AF112535 
                   Corynebacterium glutamicum  putative glutaredoxin NrdH (nrdH), Nrdl (nrdl), 
                 
                   Corynebacterium glutamicum 
                 
                 99,820 
                 5-Aug-99 
               
               
                   
                   
                   
                   
                   
                 and ribonucleotide reductase alpha-chain (nrdE) genes, complete cds. 
               
               
                   
                   
                 GB_BA1: CANRDFGEN 
                 6054 
                 Y09572 
                   Corynebacterium ammoniagenes  nrdH, nrdl, nrdE, nrdF genes. 
                 
                   Corynebacterium 
                 
                 75,966 
                 18-Apr-98 
               
               
                   
                   
                   
                   
                   
                   
                 
                   ammoniagenes 
                 
               
               
                   
                   
                 GB_BA1: MTV012 
                 70287 
                 AL021287 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 132/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 38,296 
                 23-Jun-99 
               
               
                 rxa01080 
                 567 
                 GB_BA2: AF112535 
                 4363 
                 AF112535 
                   Corynebacterium glutamicum  putative glutaredoxin NrdH (nrdH), Nrdl (nrdl), 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 5-Aug-99 
               
               
                   
                   
                   
                   
                   
                 and ribonucleotide reductase alpha-chain (nrdE) genes, complete cds. 
               
               
                   
                   
                 GB_BA1: CANRDFGEN 
                 6054 
                 Y09572 
                   Corynebacterium ammoniagenes  nrdH, nrdl, nrdE, nrdF genes. 
                 
                   Corynebacterium 
                 
                 65,511 
                 18-Apr-98 
               
               
                   
                   
                   
                   
                   
                   
                 
                   ammoniagenes 
                 
               
               
                   
                   
                 GB_BA1: STNRD 
                 4894 
                 X73226 
                   S. typhimurium  nrdEF operon. 
                 
                   Salmonella typhimurium 
                 
                 52,477 
                 03-MAR-1997 
               
               
                 rxa01087 
                 999 
                 GB_IN2: AF063412 
                 1093 
                 AF063412 
                   Limnadia lenticularis  elongation factor 1-alpha mRNA, partial cds. 
                 
                   Limnadia lenticularis 
                 
                 43,750 
                 29-MAR-1999 
               
               
                   
                   
                 GB_PR3: HS24M15 
                 134539 
                 Z94055 
                 Human DNA sequence from PAC 24M15 on chromosome 1. Contains 
                 
                   Homo sapiens 
                 
                 37,475 
                 23-Nov-99 
               
               
                   
                   
                   
                   
                   
                 tenascin-R (restrictin), EST. 
               
               
                   
                   
                 GB_IN2: ARU85702 
                 1240 
                 U85702 
                   Anathix ralla  elongation factor-1 alpha (EF-1a) gene, partial cds. 
                 
                   Anathix ralla 
                 
                 37,319 
                 16-Jul-97 
               
               
                 rxa01095 
                 857 
                 GB_BA1: MTCY01B2 
                 35938 
                 Z95554 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 72/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 43,243 
                 17-Jun-98 
               
               
                   
                   
                 GB_HTG5: AC011632 
                 175917 
                 AC011632 
                   Homo sapiens  clone RP11-3N13, WORKING DRAFT SEQUENCE, 9 
                 
                   Homo sapiens 
                 
                 36,471 
                 19-Nov-99 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                   
                   
                 GB_HTG5: AC011632 
                 175917 
                 AC011632 
                   Homo sapiens  clone RP11-3N13, WORKING DRAFT SEQUENCE, 9 
                 
                   Homo sapiens 
                 
                 36,836 
                 19-Nov-99 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                 rxa01097 
                 477 
                 GB_BA2: AF030405 
                 774 
                 AF030405 
                   Corynebacterium glutamicum  cyclase (hisF) gene, complete cds. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 13-Nov-97 
               
               
                   
                   
                 GB_BA2: AF030405 
                 774 
                 AF030405 
                   Corynebacterium glutamicum  cyclase (hisF) gene, complete cds. 
                 
                   Corynebacterium glutamicum 
                 
                 41,206 
                 13-Nov-97 
               
               
                 rxa01098 
                 897 
                 GB_BA2: AF030405 
                 774 
                 AF030405 
                   Corynebacterium glutamicum  cyclase (hisF) gene, complete cds. 
                 
                   Corynebacterium glutamicum 
                 
                 97,933 
                 13-Nov-97 
               
               
                   
                   
                 GB_BA1: MSGY223 
                 42061 
                 AD000019 
                   Mycobacterium tuberculosis  sequence from clone y223. 
                 
                   Mycobacterium tuberculosis 
                 
                 40,972 
                 10-DEC-1996 
               
               
                   
                   
                 GB_BA1: MLCB1610 
                 40055 
                 AL049913 
                   Mycobacterium leprae  cosmid B1610. 
                 
                   Mycobacterium leprae 
                 
                 61,366 
                 27-Aug-99 
               
               
                 rxa01100 
                 861 
                 GB_BA2: AF051846 
                 738 
                 AF051846 
                   Corynebacterium glutamicum  phosphoribosylformimino-5-amino-1- 
                 
                   Corynebacterium glutamicum 
                 
                 97,154 
                 12-MAR-1998 
               
               
                   
                   
                   
                   
                   
                 phosphoribosyl-4-imidazolecarboxamide isomerase (hisA) gene, 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                 GB_BA2: AF060558 
                 636 
                 AF060558 
                   Corynebacterium glutamicum  glutamine amidotransferase (hisH) gene, 
                 
                   Corynebacterium glutamicum 
                 
                 95,455 
                 29-Apr-98 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                 GB_HTG1: HSDJ140A9 
                 221755 
                 AL109917 
                   Homo sapiens  chromosome 1 clone RP1-140A9, *** SEQUENCING IN 
                 
                   Homo sapiens 
                 
                 30,523 
                 23-Nov-99 
               
               
                   
                   
                   
                   
                   
                 PROGRESS ***, in unordered pieces. 
               
               
                 rxa01101 
                 756 
                 GB_BA2: AF060558 
                 636 
                 AF060558 
                   Corynebacterium glutamicum  glutamine amidotransferase (hisH) gene, 
                 
                   Corynebacterium glutamicum 
                 
                 94,462 
                 29-Apr-98 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                 GB_BA1: SC4G6 
                 36917 
                 AL096884 
                   Streptomyces coelicolor  cosmid 4G6. 
                   Streptomyces coelicolor  A3(2) 
                 38,378 
                 23-Jul-99 
               
               
                   
                   
                 GB_BA1: STMHISOPA 
                 3981 
                 M31628 
                   S. coelicolor  histidine biosynthesis operon encoding hisD, partial cds., and 
                 
                   Streptomyces coelicolor 
                 
                 60,053 
                 26-Apr-93 
               
               
                   
                   
                   
                   
                   
                 hisC, hisB, hisH, and hisA genes, complete cds. 
               
               
                 rxa01104 
                 729 
                 GB_BA1: STMHISOPA 
                 3981 
                 M31628 
                   S. coelicolor  histidine biosynthesis operon encoding hisD, partial cds., and 
                 
                   Streptomyces coelicolor 
                 
                 58,333 
                 26-Apr-93 
               
               
                   
                   
                   
                   
                   
                 hisC, hisB, hisH, and hisA genes, complete cds. 
               
               
                   
                   
                 GB_BA1: SC4G6 
                 36917 
                 AL096884 
                   Streptomyces coelicolor  cosmid 4G6. 
                   Streptomyces coelicolor  A3(2) 
                 39,045 
                 23-Jul-99 
               
               
                   
                   
                 GB_BA1: MTCY336 
                 32437 
                 Z95586 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 70/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 60,364 
                 24-Jun-99 
               
               
                 rxa01105 
                 1221 
                 GB_BA1: MTCY336 
                 32437 
                 Z95586 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 70/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 60,931 
                 24-Jun-99 
               
               
                   
                   
                 GB_BA1: MSGY223 
                 42061 
                 AD000019 
                   Mycobacterium tuberculosis  sequence from clone y223. 
                 
                   Mycobacterium tuberculosis 
                 
                 36,851 
                 10-DEC-1996 
               
               
                   
                   
                 GB_BA1: MLCB1610 
                 40055 
                 AL049913 
                   Mycobacterium leprae  cosmid B1610. 
                 
                   Mycobacterium leprae 
                 
                 60,902 
                 27-Aug-99 
               
               
                 rxa01106 
                 1449 
                 GB_BA1: MSGY223 
                 42061 
                 AD000019 
                   Mycobacterium tuberculosis  sequence from clone y223. 
                 
                   Mycobacterium tuberculosis 
                 
                 37,233 
                 10-DEC-1996 
               
               
                   
                   
                 GB_BA1: MSHISCD 
                 2298 
                 X65542 
                   M. smegmatis  genes hisD and hisC for histidinol dehydrogenase and histidinol- 
                 
                   Mycobacterium smegmatis 
                 
                 60,111 
                 30-Jun-93 
               
               
                   
                   
                   
                   
                   
                 phosphate aminotransferase, respectively. 
               
               
                   
                   
                 GB_BA1: MTCY336 
                 32437 
                 Z95586 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 70/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 58,420 
                 24-Jun-99 
               
               
                 rxa01145 
                 1137 
                 GB_BA1: CORAIA 
                 4705 
                 L09232 
                   Corynebacterium glutamicum  acetohydroxy acid synthase (ilvB) and (ilvN) 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 23-Feb-95 
               
               
                   
                   
                   
                   
                   
                 genes, and acetohydroxy acid isomeroreductase (ilvC) gene, complete cds. 
               
               
                   
                   
                 GB_BA1: BRLILVCA 
                 1364 
                 D14551 
                   Brevibacterium flavum  ilvC gene for acetohydroxy acid isomeroreductase, 
                 
                   Corynebacterium glutamicum 
                 
                 99,560 
                 3-Feb-99 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                 GB_PAT: E08232 
                 1017 
                 E08232 
                 DNA encoding acetohydroxy-acid isomeroreductase. 
                 
                   Corynebacterium glutamicum 
                 
                 99,803 
                 29-Sep-97 
               
               
                 rxa01162 
                 1449 
                 GB_PAT: A60299 
                 2869 
                 A60299 
                 Sequence 18 from Patent WO9706261. 
                 
                   Aspergillus niger 
                 
                 38,675 
                 06-MAR-1998 
               
               
                   
                   
                 GB_PR3: HS24E5 
                 35506 
                 Z82185 
                 Human DNA sequence from Fosmid 24E5 on chromosome 22q11.2-qter 
                 
                   Homo sapiens 
                 
                 36,204 
                 23-Nov-99 
               
               
                   
                   
                   
                   
                   
                 contains parvalbumin, ESTs, STS. 
               
               
                   
                   
                 GB_PR3: AC005265 
                 43900 
                 AC005265 
                   Homo sapiens  chromosome 19, cosmid F19750, complete sequence. 
                 
                   Homo sapiens 
                 
                 38,363 
                 6-Jul-98 
               
               
                 rxa01208 
                 846 
                 GB_HTG2: AC004965 
                 323792 
                 AC004965 
                   Homo sapiens  clone DJ1106H14, *** SEQUENCING IN PROGRESS ***, 42 
                 
                   Homo sapiens 
                 
                 36,058 
                 12-Jun-98 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                   
                   
                 GB_HTG2: AC004965 
                 323792 
                 AC004965 
                   Homo sapiens  clone DJ1106H14, *** SEQUENCING IN PROGRESS ***, 42 
                 
                   Homo sapiens 
                 
                 36,058 
                 12-Jun-98 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                   
                   
                 GB_PL2: TAU55859 
                 2397 
                 U55859 
                   Triticum aestivum  heat shock protein 80 mRNA, complete cds. 
                 
                   Triticum aestivum 
                 
                 37,269 
                 1-Feb-99 
               
               
                 rxa01209 
                 1528 
                 GB_HTG3: AC011469 
                 113436 
                 AC011469 
                   Homo sapiens  chromosome 19 clone CIT-HSPC_475D23, *** SEQUENCING 
                 
                   Homo sapiens 
                 
                 40,000 
                 07-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 IN PROGRESS ***, 31 unordered pieces. 
               
               
                   
                   
                 GB_HTG3: AC011469 
                 113436 
                 AC011469 
                   Homo sapiens  chromosome 19 clone CIT-HSPC_475D23, *** SEQUENCING 
                 
                   Homo sapiens 
                 
                 40,000 
                 07-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 IN PROGRESS ***, 31 unordered pieces. 
               
               
                   
                   
                 GB_PL1: AB010077 
                 77380 
                 AB010077 
                   Arabidopsis thaliana  genomic DNA, chromosome 5, P1 clone: MYH19, 
                 
                   Arabidopsis thaliana 
                 
                 36,803 
                 20-Nov-99 
               
               
                   
                   
                   
                   
                   
                 complete sequence. 
               
               
                 rxa01215 
                 1098 
                 GB_BA1: MTCY10G2 
                 38970 
                 Z92539 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 47/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 37,047 
                 17-Jun-98 
               
               
                   
                   
                 GB_IN1: LEIPRPP 
                 1887 
                 M76553 
                   Leishmania donovani  phosphoribosylpyrophosphate synthetase gene, 
                 
                   Leishmania donovani 
                 
                 50,738 
                 7-Jun-93 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                 GB_HTG2: HSJ799D16 
                 130149 
                 AL050344 
                   Homo sapiens  chromosome 1 clone RP4-799D16 map p34.3-36.1, *** 
                 
                   Homo sapiens 
                 
                 38,135 
                 29-Nov-99 
               
               
                   
                   
                   
                   
                   
                 SEQUENCING IN PROGRESS ***, in unordered pieces. 
               
               
                 rxa01239 
                 2556 
                 GB_BA1: MTCY48 
                 35377 
                 Z74020 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 69/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 38,139 
                 17-Jun-98 
               
               
                   
                   
                 GB_PR2: AB029032 
                 6377 
                 AB029032 
                   Homo sapiens  mRNA for KIAA1109 protein, partial cds. 
                 
                   Homo sapiens 
                 
                 39,394 
                 4-Aug-99 
               
               
                   
                   
                 GB_GSS9: AQ107201 
                 355 
                 AQ107201 
                 HS_3098_A1_C03_T7 CIT Approved Human Genomic Sperm Library 
                 
                   Homo sapiens 
                 
                 41,408 
                 28-Aug-98 
               
               
                   
                   
                   
                   
                   
                 D  Homo sapiens  genomic clone Plate = 3098 Col = 5 Row = E, genomic 
               
               
                   
                   
                   
                   
                   
                 survey sequence. 
               
               
                 rxa01253 
                 873 
                 GB_PL2: F5O8 
                 99923 
                 AC005990 
                   Arabidopsis  thaliana chromosome 1 BAC F5O8 sequence, complete 
                 
                   Arabidopsis thaliana 
                 
                 36,118 
                 23-DEC-1998 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                   
                   
                 GB_PL2: F5O8 
                 99923 
                 AC005990 
                   Arabidopsis thaliana  chromosome 1 BAC F5O8 sequence, complete 
                 
                   Arabidopsis thaliana 
                 
                 35,574 
                 23-DEC-1998 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                   
                   
                 GB_IN1: CELC06G1 
                 31205 
                 U41014 
                   Caenorhabditis elegans  cosmid C06G1. 
                 
                   Caenorhabditis elegans 
                 
                 38,560 
                 30-Nov-95 
               
               
                 rxa01321 
                 1044 
                 GB_GSS14: AQ518843 
                 441 
                 AQ518843 
                 HS_5106_A1_D10_SP6E RPCI-11 Human Male BAC Library  Homo sapiens   
                 
                   Homo sapiens 
                 
                 41,121 
                 05-MAY-1999 
               
               
                   
                   
                   
                   
                   
                 genomic clone Plate = 682 Col = 19 Row = G, genomic survey sequence. 
               
               
                   
                   
                 GB_HTG2: AC007473 
                 194859 
                 AC007473 
                   Drosophila melanogaster  chromosome 2 clone BACR38D12 (D590) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 40,634 
                 2-Aug-99 
               
               
                   
                   
                   
                   
                   
                 38.D.12 map 48A-48B strain y; cn bw sp, *** SEQUENCING IN PROGRESS 
               
               
                   
                   
                   
                   
                   
                 ***, 60 unordered pieces. 
               
               
                   
                   
                 GB_HTG4: AC011696 
                 115847 
                 AC011696 
                   Drosophila melanogaster  chromosome 2 clone BACR35F01(D1156) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 38,290 
                 26-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 35.F.1 map 48A-48C strain y; cn bw sp, *** SEQUENCING IN PROGRESS 
               
               
                   
                   
                   
                   
                   
                 ***, 108 unordered pieces. 
               
               
                 rxa01352 
                 706 
                 GB_PL2: ATAC005167 
                 83260 
                 AC005167 
                   Arabidopsis thaliana  chromosome II BAC F12A24 genomic sequence, 
                 
                   Arabidopsis thaliana 
                 
                 34,311 
                 15-OCT-1998 
               
               
                   
                   
                   
                   
                   
                 complete sequence. 
               
               
                   
                   
                 GB_PL2: ATAC005825 
                 97380 
                 AC005825 
                   Arabidopsis thaliana  chromosome II BAC T24I21 genomic sequence, complete 
                 
                   Arabidopsis thaliana 
                 
                 34,311 
                 12-Apr-99 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                   
                   
                 GB_HTG3: AC011150 
                 127222 
                 AC011150 
                   Homo sapiens  clone 4_K_17, LOW-PASS SEQUENCE SAMPLING. 
                 
                   Homo sapiens 
                 
                 37,722 
                 01-OCT-1999 
               
               
                 rxa01360 
                 259 
                 GB_EST32: AI725583 
                 728 
                 AI725583 
                 BNLGHi12371 Six-day Cotton fiber  Gossypium hirsutum  cDNA 5′ similar to 
                 
                   Gossypium hirsutum 
                 
                 38,492 
                 11-Jun-99 
               
               
                   
                   
                   
                   
                   
                 (U86081) root hair defective 3 [ Arabidopsis thaliana ], mRNA sequence. 
               
               
                   
                   
                 GB_PR2: HS227P17 
                 82951 
                 Z81007 
                 Human DNA sequence from PAC 227P17, between markers DXS6791 
                 
                   Homo sapiens 
                 
                 39,738 
                 23-Nov-99 
               
               
                   
                   
                   
                   
                   
                 andDXS8038 on chromosome X contains CpG island, EST. 
               
               
                   
                   
                 GB_EST34: AV171099 
                 173 
                 AV171099 
                 AV171099  Mus musculus  head C57BL/6J 14, 17 day embryo  Mus musculus   
                 
                   Mus musculus 
                 
                 46,237 
                 6-Jul-99 
               
               
                   
                   
                   
                   
                   
                 cDNA clone 3200002M11, mRNA sequence. 
               
               
                 rxa01361 
                 629 
                 GB_RO: AB008915S1 
                 530 
                 AB008915 
                   Mus musculus  mGpi1 gene, exon 1. 
                 
                   Mus musculus 
                 
                 45,574 
                 28-Sep-99 
               
               
                   
                   
                 GB_EST22: AI050532 
                 293 
                 AI050532 
                 uc83d10.y1 Sugano mouse kidney mkia  Mus musculus  cDNA clone 
                 
                   Mus musculus 
                 
                 44,097 
                 9-Jul-98 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 1432243 5′ similar to TR: O35120 O35120 MGPI1P.;, mRNA 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                   
                   
                 GB_RO: AB008895 
                 3062 
                 AB008895 
                   Mus musculus  mRNA for mGpi1p, complete cds. 
                 
                   Mus musculus 
                 
                 41,316 
                 23-Nov-97 
               
               
                 rxa01381 
                 944 
                 GB_PL1: AB005237 
                 87835 
                 AB005237 
                   Arabidopsis thaliana  genomic DNA, chromosome 5, P1 clone: MJJ3, complete 
                 
                   Arabidopsis thaliana 
                 
                 36,606 
                 20-Nov-99 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                   
                   
                 GB_GSS5: AQ766840 
                 491 
                 AQ766840 
                 HS_2026_A2_C09_T7C CIT Approved Human Genomic Sperm Library D 
                 
                   Homo sapiens 
                 
                 37,916 
                 28-Jul-99 
               
               
                   
                   
                   
                   
                   
                   Homo sapiens  genomic clone Plate = 2026 Col = 18 Row = E, genomic survey 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                   
                   
                 GB_BA1: MTV043 
                 68848 
                 AL022004 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 40/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 37,419 
                 24-Jun-99 
               
               
                 rxa01393 
                 993 
                 GB_BA1: CGLYSEG 
                 2374 
                 X96471 
                   C. glutamicum  lysE and lysG genes. 
                 
                   Corynebacterium glutamicum 
                 
                 34,831 
                 24-Feb-97 
               
               
                   
                   
                 GB_BA1: SC5A7 
                 40337 
                 AL031107 
                   Streptomyces coelicolor  cosmid 5A7. 
                 
                   Streptomyces coelicolor 
                 
                 35,138 
                 27-Jul-98 
               
               
                   
                   
                 GB_PR3: AC004054 
                 112184 
                 AC004054 
                   Homo sapiens  chromosome 4 clone B220G8 map 4q21, complete sequence. 
                 
                   Homo sapiens 
                 
                 37,277 
                 9-Jul-98 
               
               
                 rxa01394 
                 822 
                 GB_BA1: CGLYSEG 
                 2374 
                 X96471 
                   C. glutamicum  lysE and lysG genes. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 24-Feb-97 
               
               
                   
                   
                 GB_GSS5: AQ769223 
                 500 
                 AQ769223 
                 HS_3155_B2_G10_T7C CIT Approved Human Genomic Sperm Library D 
                 
                   Homo sapiens 
                 
                 38,400 
                 28-Jul-99 
               
               
                   
                   
                   
                   
                   
                   Homo sapiens  genomic clone Plate = 3155 Col = 20 Row = N, genomic survey 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                   
                   
                 GB_BA1: CGLYSEG 
                 2374 
                 X96471 
                   C. glutamicum  lysE and lysG genes. 
                 
                   Corynebacterium glutamicum 
                 
                 33,665 
                 24-Feb-97 
               
               
                 rxa01416 
                 630 
                 GB_BA1: SC3C3 
                 31382 
                 AL031231 
                   Streptomyces coelicolor  cosmid 3C3. 
                 
                   Streptomyces coelicolor 
                 
                 62,726 
                 10-Aug-98 
               
               
                   
                   
                 GB_BA1: MLCB22 
                 40281 
                 Z98741 
                   Mycobacterium leprae  cosmid B22. 
                 
                   Mycobacterium leprae 
                 
                 39,159 
                 22-Aug-97 
               
               
                   
                   
                 GB_BA1: MTV002 
                 56414 
                 AL008967 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 122/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 37,340 
                 17-Jun-98 
               
               
                 rxa01442 
                 1347 
                 GB_BA1: D90827 
                 18886 
                 D90827 
                   E. coli  genomic DNA, Kohara clone #336(41.2-41.6 min.). 
                 
                   Escherichia coli 
                 
                 58,517 
                 21-MAR-1997 
               
               
                   
                   
                 GB_BA1: D90828 
                 14590 
                 D90828 
                   E. coli  genomic DNA, Kohara clone #336gap(41.6-41.9 min.). 
                 
                   Escherichia coil 
                 
                 56,151 
                 21-MAR-1997 
               
               
                   
                   
                 GB_BA2: AE000279 
                 10855 
                 AE000279 
                   Escherichia coli  K-12 MG1655 section 169 of 400 of the complete genome. 
                 
                   Escherichia coil 
                 
                 56,021 
                 12-Nov-98 
               
               
                 rxa01446 
                 1413 
                 GB_BA1: SCH10 
                 39524 
                 AL049754 
                   Streptomyces coelicolor  cosmid H10. 
                 
                   Streptomyces coelicolor 
                 
                 39,037 
                 04-MAY-1999 
               
               
                   
                   
                 GB_BA1: MTY13E10 
                 35019 
                 Z95324 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 18/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 40,130 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MLCB4 
                 36310 
                 AL023514 
                   Mycobacterium leprae  cosmid B4. 
                 
                   Mycobacterium leprae 
                 
                 37,752 
                 27-Aug-99 
               
               
                 rxa01483 
                 1395 
                 GB_BA1: MTCY98 
                 31225 
                 Z83860 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 103/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 39,057 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MSGB1229CS 
                 30670 
                 L78812 
                   Mycobacterium leprae  cosmid B1229 DNA sequence. 
                 
                   Mycobacterium leprae 
                 
                 54,382 
                 15-Jun-96 
               
               
                   
                   
                 GB_BA2: AF027507 
                 5168 
                 AF027507 
                   Mycobacterium smegmatis  dGTPase (dgt), and primase (dnaG) genes, 
                 
                   Mycobacterium smegmatis 
                 
                 52,941 
                 16-Jan-98 
               
               
                   
                   
                   
                   
                   
                 complete cds; tRNA-Asn gene, complete sequence. 
               
               
                 rxa01486 
                 757 
                 GB_BA1: MTV002 
                 56414 
                 AL008967 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 122/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 40,941 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MLCB22 
                 40281 
                 Z98741 
                   Mycobacterium leprae  cosmid B22. 
                 
                   Mycobacterium leprae 
                 
                 38,451 
                 22-Aug-97 
               
               
                   
                   
                 GB_BA1: SC3C3 
                 31382 
                 AL031231 
                   Streptomyces coelicolor  cosmid 3C3. 
                 
                   Streptomyces coelicolor 
                 
                 61,194 
                 10-Aug-98 
               
               
                 rxa01489 
                 1146 
                 GB_BA1: CORFADS 
                 1547 
                 D37967 
                   Corynebacterium ammoniagenes  gene for FAD synthetase, complete cds. 
                 
                   Corynebacterium 
                 
                 58,021 
                 8-Feb-99 
               
               
                   
                   
                   
                   
                   
                   
                 
                   ammoniagenes 
                 
               
               
                   
                   
                 GB_BA1: MLCB22 
                 40281 
                 Z98741 
                   Mycobacterium leprae  cosmid B22. 
                 
                   Mycobacterium leprae 
                 
                 38,414 
                 22-Aug-97 
               
               
                   
                   
                 GB_BA1: SC10A7 
                 39739 
                 AL078618 
                   Streptomyces coelicolor  cosmid 10A7. 
                 
                   Streptomyces coelicolor 
                 
                 36,930 
                 9-Jun-99 
               
               
                 rxa01491 
                 774 
                 GB_BA1: MTV002 
                 56414 
                 AL008967 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 122/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 37,062 
                 17-Jun-98 
               
               
                   
                   
                 GB_EST13: AA356956 
                 255 
                 AA356956 
                 EST65614 Jurkat T-cells III  Homo sapiens  cDNA 5′ end, mRNA sequence. 
                 
                   Homo sapiens 
                 
                 37,647 
                 21-Apr-97 
               
               
                   
                   
                 GB_OV: OMDNAPROI 
                 7327 
                 X92380 
                   O. mossambicus  prolactin I gene. 
                 
                   Tilapia mossambica 
                 
                 38,289 
                 19-OCT-1995 
               
               
                 rxa01508 
                 1662 
                 GB_IN1: CEF28C12 
                 14653 
                 Z93380 
                   Caenorhabditis elegans  cosmid F28C12, complete sequence. 
                 
                   Caenorhabditis elegans 
                 
                 37,984 
                 23-Nov-98 
               
               
                   
                   
                 GB_IN1: CEF28C12 
                 14653 
                 Z93380 
                   Caenorhabditis elegans  cosmid F28C12, complete sequence. 
                 
                   Caenorhabditis elegans 
                 
                 38,469 
                 23-Nov-98 
               
               
                 rxa01512 
                 723 
                 GB_BA1: SCE9 
                 37730 
                 AL049841 
                   Streptomyces coelicolor  cosmid E9. 
                 
                   Streptomyces coelicolor 
                 
                 39,021 
                 19-MAY-1999 
               
               
                   
                   
                 GB_BA1: MAU88875 
                 840 
                 U88875 
                   Mycobacterium avium  hypoxanthine-guanine phosphoribosyl transferase gene, 
                 
                   Mycobacterium avium 
                 
                 57,521 
                 05-MAR-1997 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                 GB_BA1: MTY15C10 
                 33050 
                 Z95436 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 154/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 40,086 
                 17-Jun-98 
               
               
                 rxa01514 
                 711 
                 GB_BA1: MTCY7H7B 
                 24244 
                 Z95557 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 153/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 43,343 
                 18-Jun-98 
               
               
                   
                   
                 GB_BA1: MLCB2548 
                 38916 
                 AL023093 
                   Mycobacterium leprae  cosmid B2548. 
                 
                   Mycobacterium leprae 
                 
                 38,177 
                 27-Aug-99 
               
               
                   
                   
                 GB_PL1: EGGTPCHI 
                 242 
                 Z49757 
                   E. gracilis  mRNA for GTP cyclohydrolase I (core region). 
                 
                   Euglena gracilis 
                 
                 64,876 
                 20-OCT-1995 
               
               
                 rxa01515 
                 975 
                 GB_BA1: ECOUW93 
                 338534 
                 U14003 
                   Escherichia coli  K-12 chromosomal region from 92.8 to 00.1 minutes. 
                 
                   Escherichia coli 
                 
                 38,943 
                 17-Apr-96 
               
               
                   
                   
                 GB_BA1: ECOUW93 
                 338534 
                 U14003 
                   Escherichia coli  K-12 chromosomal region from 92.8 to 00.1 minutes. 
                 
                   Escherichia coli 
                 
                 37,500 
                 17-Apr-96 
               
               
                   
                   
                 GB_BA1: MTCY49 
                 39430 
                 Z73966 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 93/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 38,010 
                 24-Jun-99 
               
               
                 rxa01516 
                 513 
                 GB_IN1: DME238847 
                 5419 
                 AJ238847 
                   Drosophila melanogaster  mRNA for  drosophila  dodeca-satellite protein 1 (DDP- 
                 
                   Drosophila melanogaster 
                 
                 36,346 
                 13-Aug-99 
               
               
                   
                   
                   
                   
                   
                 1). 
               
               
                   
                   
                 GB_HTG3: AC009210 
                 103814 
                 AC009210 
                   Drosophila melanogaster  chromosome 2 clone BACR01I06 (D1054) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 37,897 
                 20-Aug-99 
               
               
                   
                   
                   
                   
                   
                 01.I.6 map 55D—55D strain y; cn bw sp, *** SEQUENCING IN 
               
               
                   
                   
                   
                   
                   
                 PROGRESS ***, 86 unordered pieces. 
               
               
                   
                   
                 GB_IN2: AF132179 
                 4842 
                 AF132179 
                   Drosophila melanogaster  clone LD21677 unknown mRNA. 
                 
                   Drosophila melanogaster 
                 
                 36,149 
                 3-Jun-99 
               
               
                 rxa01517 
                 600 
                 GB_PL2: F6H8 
                 82596 
                 AF178045 
                   Arabidopsis thaliana  BAC F6H8. 
                 
                   Arabidopsis thaliana 
                 
                 35,846 
                 19-Aug-99 
               
               
                   
                   
                 GB_PL2: AF038831 
                 647 
                 AF038831 
                   Sorosporium saponariae  internal transcribed spacer 1, 5.8S ribosomal RNA 
                 
                   Sorosporium saponariae 
                 
                 40,566 
                 13-Apr-99 
               
               
                   
                   
                   
                   
                   
                 gene; and internal transcribed spacer 2, complete sequence. 
               
               
                   
                   
                 GB_PL2: ATAC005957 
                 108355 
                 AC005957 
                   Arabidopsis thaliana  chromosome II BAC T15J14 genomic sequence, 
                 
                   Arabidopsis thaliana 
                 
                 38,095 
                 7-Jan-99 
               
               
                   
                   
                   
                   
                   
                 complete sequence. 
               
               
                 rxa01521 
                 921 
                 GB_BA1: ANANIFBH 
                 5936 
                 J05111 
                   Anabaena  sp. (clone AnH20.1) nitrogen fixation operon nifB, fdxN, nifS, nifU, 
                   Anabaena  sp. 
                 38,206 
                 26-Apr-93 
               
               
                   
                   
                   
                   
                   
                 and nifH genes, complete cds. 
               
               
                   
                   
                 GB_PR2: AC002461 
                 197273 
                 AC002461 
                 Human BAC clone RG204I16 from 7q31, complete sequence. 
                 
                   Homo sapiens 
                 
                 36,623 
                 20-Aug-97 
               
               
                   
                   
                 GB_PR2: AC002461 
                 197273 
                 AC002461 
                 Human BAC clone RG204I16 from 7q31, complete sequence. 
                 
                   Homo sapiens 
                 
                 34,719 
                 20-Aug-97 
               
               
                 rxa01528 
                 651 
                 GB_RO: MM437P9 
                 165901 
                 AL049866 
                   Mus musculus  chromosome X, clone 437P9. 
                 
                   Mus musculus 
                 
                 37,500 
                 29-Jun-99 
               
               
                   
                   
                 GB_PR3: AC005740 
                 186780 
                 AC005740 
                   Homo sapiens  chromosome 5p, BAC clone 50g21 (LBNL H154), complete 
                 
                   Homo sapiens 
                 
                 37,031 
                 01-OCT-1998 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                   
                   
                 GB_PR3: AC005740 
                 186780 
                 AC005740 
                   Homo sapiens  chromosome 5p, BAC clone 50g21 (LBNL H154), complete 
                 
                   Homo sapiens 
                 
                 38,035 
                 01-OCT-1998 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                 rxa01551 
                 1998 
                 GB_BA1: MTCY22G10 
                 35420 
                 Z84724 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 21/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 38,371 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA2: ECOUW89 
                 176195 
                 U00006 
                   E. coli  chromosomal region from 89.2 to 92.8 minutes. 
                 
                   Escherichia coli 
                 
                 38,064 
                 17-DEC-1993 
               
               
                   
                   
                 GB_BA1: SCQ11 
                 15441 
                 AL096823 
                   Streptomyces coelicolor  cosmid Q11. 
                 
                   Streptomyces coelicolor 
                 
                 60,775 
                 8-Jul-99 
               
               
                 rxa01561 
                 1053 
                 GB_IN1: CEY62H9A 
                 47396 
                 AL032630 
                   Caenorhabditis elegans  cosmid Y62H9A, complete sequence. 
                 
                   Caenorhabditis elegans 
                 
                 38,514 
                 2-Sep-99 
               
               
                   
                   
                 GB_PR4: HSU51003 
                 3202 
                 U51003 
                   Homo sapiens  DLX-2 (DLX-2) gene, complete cds. 
                 
                   Homo sapiens 
                 
                 37,730 
                 07-DEC-1999 
               
               
                   
                   
                 GB_OM: PIGDAO1 
                 395 
                 M18444 
                 Pig D-amino acid oxidase (DAO) gene, exon 1. 
                 
                   Sus scrofa 
                 
                 39,340 
                 27-Apr-93 
               
               
                 rxa01599 
                 1785 
                 GB_BA1: MTCI125 
                 37432 
                 Z98268 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 76/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 63,300 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: U00021 
                 39193 
                 U00021 
                   Mycobacterium leprae  cosmid L247. 
                 
                   Mycobacterium leprae 
                 
                 36,756 
                 29-Sep-94 
               
               
                   
                   
                 GB_BA1: MLCB1351 
                 38936 
                 Z95117 
                   Mycobacterium leprae  cosmid B1351. 
                 
                   Mycobacterium leprae 
                 
                 36,756 
                 24-Jun-97 
               
               
                 rxa01617 
                 795 
                 GB_PR2: HSMTM0 
                 217657 
                 AL034384 
                 Human chromosome Xq28, cosmid clones 7H3, 14D7, C1230, 11E7, F1096, 
                 
                   Homo sapiens 
                 
                 40,811 
                 5-Jul-99 
               
               
                   
                   
                   
                   
                   
                 A12197, 12G8, A09100; complete sequence bases 1. .217657. 
               
               
                   
                   
                 GB_PR2: HS13D10 
                 153147 
                 AL021407 
                   Homo sapiens  DNA sequence from PAC 13D10 on chromosome 6p22.3-23. 
                 
                   Homo sapiens 
                 
                 38,768 
                 23-Nov-99 
               
               
                   
                   
                   
                   
                   
                 Contains CpG island. 
               
               
                   
                   
                 GB_PR2: HSMTM0 
                 217657 
                 AL034384 
                 Human chromosome Xq28, cosmid clones 7H3, 14D7, C1230, 11E7, F1096, 
                 
                   Homo sapiens 
                 
                 39,018 
                 5-Jul-99 
               
               
                   
                   
                   
                   
                   
                 A12197, 12G8; A09100; complete sequence bases 1. .217657. 
               
               
                 rxa01657 
                 723 
                 GB_BA1: MTCY1A10 
                 25949 
                 Z95387 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 117/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 40,656 
                 17-Jun-98 
               
               
                   
                   
                 GB_EST6: D79278 
                 392 
                 D79278 
                 HUM213D06B Human aorta polyA+ (TFujiwara)  Homo sapiens  cDNA clone 
                 
                   Homo sapiens 
                 
                 44,262 
                 9-Feb-96 
               
               
                   
                   
                   
                   
                   
                 GEN-213D06 5′, mRNA sequence. 
               
               
                   
                   
                 GB_BA2: AF129925 
                 10243 
                 AF129925 
                   Thiobacillus ferrooxidans  carboxysome operon, complete cds. 
                 
                   Thiobacillus ferrooxidans 
                 
                 40,709 
                 17-MAY-1999 
               
               
                 rxa01660 
                 675 
                 GB_BA1: MTV013 
                 11364 
                 AL021309 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 134/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 40,986 
                 17-Jun-98 
               
               
                   
                   
                 GB_RO: MMFV1 
                 6480 
                 X97719 
                   M. musculus  retrovirus restriction gene Fv1. 
                 
                   Mus musculus 
                 
                 35,364 
                 29-Aug-96 
               
               
                   
                   
                 GB_PAT: A67508 
                 6480 
                 A67508 
                 Sequence 1 from Patent WO9743410. 
                 
                   Mus musculus 
                 
                 35,364 
                 05-MAY-1999 
               
               
                 rxa01678 
                 651 
                 GB_VI: TVU95309 
                 600 
                 U95309 
                 Tula virus O64 nucleocapsid protein gene, partial cds. 
                 Tula virus 
                 41,894 
                 28-OCT-1997 
               
               
                   
                   
                 GB_VI: TVU95303 
                 600 
                 U95303 
                 Tula virus O52 nucleocapsid protein gene, partial cds. 
                 Tula virus 
                 41,712 
                 28-OCT-1997 
               
               
                   
                   
                 GB_VI: TVU95302 
                 600 
                 U95302 
                 Tula virus O24 nucleocapsid protein gene, partial cds. 
                 Tula virus 
                 39,576 
                 28-OCT-1997 
               
               
                 rxa01679 
                 1359 
                 GB_EST5: H91843 
                 362 
                 H91843 
                 ys81e01.s1 Soares retina N2b4HR  Homo sapiens  cDNA clone IMAGE: 221208 
                 
                   Homo sapiens 
                 
                 39,157 
                 29-Nov-95 
               
               
                   
                   
                   
                   
                   
                 3′ similar to gb: X63749_rna1 GUANINE NUCLEOTIDE-BINDING PROTEIN 
               
               
                   
                   
                   
                   
                   
                 G(T), ALPHA-1 (HUMAN);, mRNA sequence. 
               
               
                   
                   
                 GB_STS: G26925 
                 362 
                 G26925 
                 human STS SHGC-30023, sequence tagged site. 
                 
                   Homo sapiens 
                 
                 39,157 
                 14-Jun-96 
               
               
                   
                   
                 GB_PL2: AF139451 
                 1202 
                 AF139451 
                   Gossypium robinsonii  CeIA2 pseudogene, partial sequence. 
                 
                   Gossypium robinsonii 
                 
                 38,910 
                 1-Jun-99 
               
               
                 rxa01690 
                 1224 
                 GB_BA1: SC1C2 
                 42210 
                 AL031124 
                   Streptomyces coelicolor  cosmid 1C2. 
                 
                   Streptomyces coelicolor 
                 
                 60,644 
                 15-Jan-99 
               
               
                   
                   
                 GB_EST22: AI064232 
                 493 
                 AI064232 
                 GH04563.5prime GH  Drosophila melanogaster  head pOT2  Drosophila   
                 
                   Drosophila melanogaster 
                 
                 38,037 
                 24-Nov-98 
               
               
                   
                   
                   
                   
                   
                   melanogaster  cDNA clone GH04563 5prime, mRNA sequence. 
               
               
                   
                   
                 GB_IN2: AF117896 
                 1020 
                 AF117896 
                   Drosophila melanogaster  neuropeptide F (npf) gene, complete cds. 
                 
                   Drosophila melanogaster 
                 
                 36,122 
                 2-Jul-99 
               
               
                 rxa01692 
                 873 
                 GB_BA2: AF067123 
                 1034 
                 AF067123 
                   Lactobacillus reuteri  cobalamin biosynthesis protein J (cbiJ) gene, partial cds; 
                 
                   Lactobacillus reuteri 
                 
                 48,079 
                 3-Jun-98 
               
               
                   
                   
                   
                   
                   
                 and uroporphyrin-III C-methyltransferase (sumT) gene, complete cds. 
               
               
                   
                   
                 GB_RO: RATNFHPEP 
                 3085 
                 M37227 
                 Rat heavy neurofilament (NF-H) polypeptide, partial cds. 
                 
                   Rattus norvegicus 
                 
                 37,093 
                 27-Apr-93 
               
               
                   
                   
                 GB_RO: RSNFH 
                 3085 
                 X13804 
                 Rat mRNA for heavy neurofilament polypeptide NF-H C-terminus. 
                   Rattus  sp. 
                 37,093 
                 14-Jul-95 
               
               
                 rxa01698 
                 1353 
                 GB_BA2: AF124600 
                 4115 
                 AF124600 
                   Corynebacterium glutamicum  chorismate synthase (aroC), shikimate kinase 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 04-MAY-1999 
               
               
                   
                   
                   
                   
                   
                 (aroK), and 3-dehydroquinate synthase (aroB) genes, complete cds; and 
               
               
                   
                   
                   
                   
                   
                 putative cytoplasmic peptidase (pepQ) gene, partial cds. 
               
               
                   
                   
                 GB_BA1: MTCY159 
                 33818 
                 Z83863 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 111/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 36,323 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MSGB937CS 
                 38914 
                 L78820 
                   Mycobacterium leprae  cosmid B937 DNA sequence. 
                 
                   Mycobacterium leprae 
                 
                 62,780 
                 15-Jun-96 
               
               
                 rxa01699 
                 693 
                 GB_BA2: AF124600 
                 4115 
                 AF124600 
                   Corynebacterium glutamicum  chorismate synthase (aroC), shikimate kinase 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 04-MAY-1999 
               
               
                   
                   
                   
                   
                   
                 (aroK), and 3-dehydroquinate synthase (aroB) genes, complete cds; and 
               
               
                   
                   
                   
                   
                   
                 putative cytoplasmic peptidase (pepQ) gene, partial cds. 
               
               
                   
                   
                 GB_BA2: AF016585 
                 41097 
                 AF016585 
                   Streptomyces caelestis  cytochrome P-450 hydroxylase homolog (nidi) gene, 
                 
                   Streptomyces caelestis 
                 
                 40,260 
                 07-DEC-1997 
               
               
                   
                   
                   
                   
                   
                 partial cds; polyketide synthase modules 1 through 7 (nidA) genes, complete 
               
               
                   
                   
                   
                   
                   
                 cds; and N-methyltransferase homolog gene, partial cds. 
               
               
                   
                   
                 GB_EST9: C19712 
                 399 
                 C19712 
                 C19712 Rice panicle at ripening stage  Oryza sativa  cDNA clone E10821_1A, 
                 
                   Oryza sativa 
                 
                 45,425 
                 24-OCT-1996 
               
               
                   
                   
                   
                   
                   
                 mRNA sequence. 
               
               
                 rxa01712 
                 805 
                 GB_EST21: AA952466 
                 278 
                 AA952466 
                 TENS1404  T. cruzi  epimastigote normalized cDNA Library  Trypanosoma cruzi   
                 
                   Trypanosoma cruzi 
                 
                 40,876 
                 29-OCT-1998 
               
               
                   
                   
                   
                   
                   
                 cDNA clone 1404 5′, mRNA sequence. 
               
               
                 rxa01850 
                 1470 
                 GB_BA2: ECOUW67_0 
                 110000 
                 U18997 
                   Escherichia coli  K-12 chromosomal region from 67.4 to 76.0 minutes. 
                 
                   Escherichia coli 
                 
                 37,196 
                 U18997 
               
               
                   
                   
                 GB_BA2: AE000392 
                 10345 
                 AE000392 
                   Escherichia coli  K-12 MG1655 section 282 of 400 of the complete genome. 
                 
                   Escherichia coli 
                 
                 38,021 
                 12-Nov-98 
               
               
                   
                   
                 GB_BA2: U32715 
                 13136 
                 U32715 
                   Haemophilus influenzae  Rd section 30 of 163 of the complete genome. 
                   Haemophilus influenzae  Rd 
                 39,860 
                 29-MAY-1998 
               
               
                 rxa01878 
                 1002 
                 GB_HTG1: CEY64F11 
                 177748 
                 Z99776 
                   Caenorhabditis elegans  chromosome IV clone Y64F11, *** SEQUENCING IN 
                 
                   Caenorhabditis elegans 
                 
                 37,564 
                 14-OCT-1998 
               
               
                   
                   
                   
                   
                   
                 PROGRESS ***, in unordered pieces. 
               
               
                   
                   
                 GB_HTG1: CEY64F11 
                 177748 
                 Z99776 
                   Caenorhabditis elegans  chromosome IV clone Y64F11, *** SEQUENCING IN 
                 
                   Caenorhabditis elegans 
                 
                 37,564 
                 14-OCT-1998 
               
               
                   
                   
                   
                   
                   
                 PROGRESS ***, in unordered pieces. 
               
               
                   
                   
                 GB_HTG1: CEY64F11 
                 177748 
                 Z99776 
                   Caenorhabditis elegans  chromosome IV clone Y64F11, *** SEQUENCING IN 
                 
                   Caenorhabditis elegans 
                 
                 37,576 
                 14-OCT-1998 
               
               
                   
                   
                   
                   
                   
                 PROGRESS ***, in unordered pieces. 
               
               
                 rxa01892 
                 852 
                 GB_BA1: MTCY274 
                 39991 
                 Z74024 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 126/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 35,910 
                 19-Jun-98 
               
               
                   
                   
                 GB_BA1: MLCB250 
                 40603 
                 Z97369 
                   Mycobacterium leprae  cosmid B250. 
                 
                   Mycobacterium leprae 
                 
                 64,260 
                 27-Aug-99 
               
               
                   
                   
                 GB_BA1: MSGB1529CS 
                 36985 
                 L78824 
                   Mycobacterium leprae  cosmid B1529 DNA sequence. 
                 
                   Mycobacterium leprae 
                 
                 64,260 
                 15-Jun-96 
               
               
                 rxa01894 
                 978 
                 GB_BA1: MTCY274 
                 39991 
                 Z74024 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 126/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 37,229 
                 19-Jun-98 
               
               
                   
                   
                 GB_IN1: CELF46H5 
                 38886 
                 U41543 
                   Caenorhabditis elegans  cosmid F46H5. 
                 
                   Caenorhabditis elegans 
                 
                 38,525 
                 29-Nov-96 
               
               
                   
                   
                 GB_HTG3: AC009204 
                 115633 
                 AC009204 
                   Drosophila melanogaster  chromosome 2 clone BACR03E19 (D1033) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 31,579 
                 18-Aug-99 
               
               
                   
                   
                   
                   
                   
                 03.E.19 map 36E-37C strain y; cn bw sp, *** SEQUENCING IN PROGRESS 
               
               
                   
                   
                   
                   
                   
                 ***, 94 unordered pieces. 
               
               
                 rxa01920 
                 1125 
                 GB_BA2: AF112536 
                 1798 
                 AF112536 
                   Corynebacterium glutamicum  ribonucleotide reductase beta-chain (nrdF) 
                 
                   Corynebacterium glutamicum 
                 
                 99,733 
                 5-Aug-99 
               
               
                   
                   
                   
                   
                   
                 gene, complete cds. 
               
               
                   
                   
                 GB_BA1: CANRDFGEN 
                 6054 
                 Y09572 
                   Corynebacterium ammoniagenes  nrdH, nrdI, nrdE, nrdF genes. 
                 
                   Corynebacterium 
                 
                 70,321 
                 18-Apr-98 
               
               
                   
                   
                   
                   
                   
                   
                 
                   ammoniagenes 
                 
               
               
                   
                   
                 GB_BA2: AF050168 
                 1228 
                 AF050168 
                   Corynebacterium ammoniagenes  ribonucleoside diphosphate reductase small 
                 
                   Corynebacterium 
                 
                 72,082 
                 23-Apr-98 
               
               
                   
                   
                   
                   
                   
                 subunit (nrdF) gene, complete cds. 
                 
                   ammoniagenes 
                 
               
               
                 rxa01928 
                 960 
                 GB_BA1: CGPAN 
                 2164 
                 X96580 
                   C. glutamicum  panB, panC &amp; xylB genes. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 11-MAY-1999 
               
               
                   
                   
                 GB_PL1: AP000423 
                 154478 
                 AP000423 
                   Arabidopsis thaliana  chloroplast genomic DNA, complete sequence, 
                 Chloroplast  Arabidopsis   
                 35,917 
                 15-Sep-99 
               
               
                   
                   
                   
                   
                   
                 strain: Columbia. 
                 
                   thaliana 
                 
               
               
                   
                   
                 GB_PL1: AP000423 
                 154478 
                 AP000423 
                   Arabidopsis thaliana  chloroplast genomic DNA, complete sequence, 
                 Chloroplast  Arabidopsis   
                 33,925 
                 15-Sep-99 
               
               
                   
                   
                   
                   
                   
                 strain: Columbia. 
                 
                   thaliana 
                 
               
               
                 rxa01929 
                 936 
                 GB_BA1: CGPAN 
                 2164 
                 X96580 
                   C. glutamicum  panB, panC &amp; xylB genes. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 11-MAY-1999 
               
               
                   
                   
                 GB_BA1: XCU33548 
                 8429 
                 U33548 
                   Xanthomonas campestris  hrpB pathogenicity locus proteins HrpB1, HrpB2, 
                 
                   Xanthomonas campestris pv. 
                 
                 38,749 
                 19-Sep-96 
               
               
                   
                   
                   
                   
                   
                 HrpB3, HrpB4, HrpB5, HrpB6, HrpB7, HrpB8, HrpA1, and ORF62 
                 
                   vesicatoria 
                 
               
               
                   
                   
                   
                   
                   
                 genes, complete cds. 
               
               
                   
                   
                 GB_BA1: XANHRPB6A 
                 1329 
                 M99174 
                   Xanthomonas campestris  hrpB6 gene, complete cds. 
                 
                   Xanthomonas campestris 
                 
                 39,305 
                 14-Sep-93 
               
               
                 rxa01940 
                 1059 
                 GB_IN2: CFU43371 
                 1060 
                 U43371 
                   Crithidia fasciculata  inosine-uridine preferring nucleoside hydrolase (IUNH) 
                 
                   Crithidia fasciculata 
                 
                 61,417 
                 18-Jun-96 
               
               
                   
                   
                   
                   
                   
                 gene, complete cds. 
               
               
                   
                   
                 GB_BA2: AE001467 
                 11601 
                 AE001467 
                   Helicobacter pylori , strain J99 section 28 of 132 of the complete genome. 
                 
                   Helicobacter pylori J99 
                 
                 38,560 
                 20-Jan-99 
               
               
                   
                   
                 GB_RO: AF175967 
                 3492 
                 AF175967 
                   Homo sapiens  Leman coiled-coil protein (LCCP) mRNA, complete cds. 
                 
                   Mus musculus 
                 
                 40,275 
                 26-Sep-99 
               
               
                 rxa02022 
                 1230 
                 GB_BA1: CGDAPE 
                 1966 
                 X81379 
                   C. glutamicum  dapE gene and orf2. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 8-Aug-95 
               
               
                   
                   
                 GB_BA1: CGDNAAROP 
                 2612 
                 X85965 
                   C. glutamicum  ORF3 and aroP gene. 
                 
                   Corynebacterium glutamicum 
                 
                 38,889 
                 30-Nov-97 
               
               
                   
                   
                 GB_BA1: APU47055 
                 6469 
                 U47055 
                   Anabaena PCC7120  nitrogen fixation proteins (nifE, nifN, nifX, nifW) genes, 
                 
                   Anabaena PCC7120 
                 
                 36,647 
                 17-Feb-96 
               
               
                   
                   
                   
                   
                   
                 complete cds, and nitrogenase (nifK) and hesA genes, partial cds. 
               
               
                 rxa02024 
                 859 
                 GB_BA1: MTCI364 
                 29540 
                 Z93777 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 52/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 59,415 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MSGB1912CS 
                 38503 
                 L01536 
                   M. leprae  genomic dna sequence, cosmid b1912. 
                 
                   Mycobacterium leprae 
                 
                 57,093 
                 14-Jun-96 
               
               
                   
                   
                 GB_BA1: MLU15180 
                 38675 
                 U15180 
                   Mycobacterium leprae  cosmid B1756. 
                 
                   Mycobacterium leprae 
                 
                 57,210 
                 09-MAR-1995 
               
               
                 rxa02027 
               
               
                 rxa02031 
               
               
                 rxa02072 
                 1464 
                 GB_BA1: CGGDHA 
                 2037 
                 X72855 
                   C. glutamicum  GDHA gene. 
                 
                   Corynebacterium glutamicum 
                 
                 99,317 
                 24-MAY-1993 
               
               
                   
                   
                 GB_BA1: CGGDH 
                 2037 
                 X59404 
                   Corynebacterium glutamicum , gdh gen for glutamate dehydrogenase. 
                 
                   Corynebacterium glutamicum 
                 
                 94,387 
                 30-Jul-99 
               
               
                   
                   
                 GB_BA1: PAE18494 
                 1628 
                 Y18494 
                   Pseudomonas aeruginosa  gdhA gene, strain PAC1. 
                 
                   Pseudomonas aeruginosa 
                 
                 62,247 
                 6-Feb-99 
               
               
                 rxa02085 
                 2358 
                 GB_BA1: MTCY22G8 
                 22550 
                 Z95585 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 49/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 38,442 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MLCB33 
                 42224 
                 Z94723 
                   Mycobacterium leprae  cosmid B33. 
                 
                   Mycobacterium leprae 
                 
                 56,486 
                 24-Jun-97 
               
               
                   
                   
                 GB_BA1: ECOUW85 
                 91414 
                 M87049 
                   E. coli  genomic sequence of the region from 84.5 to 86.5 minutes. 
                 
                   Escherichia coli 
                 
                 52,127 
                 29-MAY-1995 
               
               
                 rxa02093 
                 927 
                 GB_EST14: AA448146 
                 452 
                 AA448146 
                 zw82h01.r1 Soares_testis_NHT  Homo sapiens  cDNA clone IMAGE: 782737 5′, 
                 
                   Homo sapiens 
                 
                 34,163 
                 4-Jun-97 
               
               
                   
                   
                   
                   
                   
                 mRNA sequence. 
               
               
                   
                   
                 GB_EST17: AA641937 
                 444 
                 AA641937 
                 ns18b10.r1 NCI_CGAP_GCB1  Homo sapiens  cDNA clone IMAGE: 
                 
                   Homo sapiens 
                 
                 35,586 
                 27-OCT-1997 
               
               
                   
                   
                   
                   
                   
                 1183963 5′, mRNA sequence. 
               
               
                   
                   
                 GB_PR3: AC003074 
                 143029 
                 AC003074 
                 Human PAC clone DJ0596O09 from 7p15, complete sequence. 
                 
                   Homo sapiens 
                 
                 31,917 
                 6-Nov-97 
               
               
                 rxa02106 
                 1179 
                 GB_BA1: SC1A6 
                 37620 
                 AL023496 
                   Streptomyces coelicolor  cosmid 1A6. 
                 
                   Streptomyces coelicolor 
                 
                 35,818 
                 13-Jan-99 
               
               
                   
                   
                 GB_PR4: AC005553 
                 179651 
                 AC005553 
                   Homo sapiens  chromosome 17, clone hRPK.112_J_9, complete sequence. 
                 
                   Homo sapiens 
                 
                 34,274 
                 31-DEC-1998 
               
               
                   
                   
                 GB_EST3: R49746 
                 397 
                 R49746 
                 yg71g10.r1 Soares infant brain 1NIB  Homo sapiens  cDNA clone 
                 
                   Homo sapiens 
                 
                 41,162 
                 18-MAY-1995 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 38768 5′ similar to gb: V00567 BETA-2-MICROGLOBULIN 
               
               
                   
                   
                   
                   
                   
                 PRECURSOR (HUMAN);, mRNA sequence. 
               
               
                 rxa02111 
                 1407 
                 GB_BA1: SC6G10 
                 36734 
                 AL049497 
                   Streptomyces coelicolor  cosmid 6G10. 
                 
                   Streptomyces coelicolor 
                 
                 50,791 
                 24-MAR-1999 
               
               
                   
                   
                 GB_BA1: U00010 
                 41171 
                 U00010 
                   Mycobacterium leprae  cosmid B1170. 
                 
                   Mycobacterium leprae 
                 
                 37,563 
                 01-MAR-1994 
               
               
                   
                   
                 GB_BA1: MTCY336 
                 32437 
                 Z95586 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 70/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 39,504 
                 24-Jun-99 
               
               
                 rxa02112 
                 960 
                 GB_HTG3: AC010579 
                 157658 
                 AC010579 
                   Drosophila melanogaster  chromosome 3 clone BACR09D08 (D1101) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 37,909 
                 24-Sep-99 
               
               
                   
                   
                   
                   
                   
                 09.D.8 map 96F-96F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 
               
               
                   
                   
                   
                   
                   
                 121 unordered pieces. 
               
               
                   
                   
                 GB_GSS3: B09839 
                 1191 
                 B09839 
                 T12A12-Sp6 TAMU  Arabidopsis thaliana  genomic clone T12A12, genomic 
                 
                   Arabidopsis thaliana 
                 
                 37,843 
                 14-MAY-1997 
               
               
                   
                   
                   
                   
                   
                 survey sequence. 
               
               
                   
                   
                 GB_HTG3: AC010579 
                 157658 
                 AC010579 
                   Drosophila melanogaster  chromosome 3 clone BACR09D08 (D1101) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 37,909 
                 24-Sep-99 
               
               
                   
                   
                   
                   
                   
                 09.D.8 map 96F-96F strain y; cn bw sp, *** SEQUENCING IN PROGRESS ***, 
               
               
                   
                   
                   
                   
                   
                 121 unordered pieces. 
               
               
                 rxa02134 
                 1044 
                 GB_BA1: SCSECYDNA 
                 6154 
                 X83011 
                   S. coelicolor  secY locus DNA. 
                 
                   Streptomyces coelicolor 
                 
                 36,533 
                 02-MAR-1998 
               
               
                   
                   
                 GB_EST32: AI731596 
                 568 
                 AI731596 
                 BNLGHi10185 Six-day Cotton fiber  Gossypium hirsutum  cDNA 5′ similar to 
                 
                   Gossypium hirsutum 
                 
                 33,451 
                 11-Jun-99 
               
               
                   
                   
                   
                   
                   
                 (AC004005) putative ribosomal protein L7 [ Arabidopsis thaliana ], mRNA 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                   
                   
                 GB_BA1: SCSECYDNA 
                 6154 
                 X83011 
                   S. coelicolor  secY locus DNA. 
                 
                   Streptomyces coelicolor 
                 
                 36,756 
                 02-MAR-1998 
               
               
                 rxa02135 
                 1197 
                 GB_PR3: HS525L6 
                 168111 
                 AL023807 
                 Human DNA sequence from clone RP3-525L6 on chromosome 6p22.3-23 
                 
                   Homo sapiens 
                 
                 34,365 
                 23-Nov-99 
               
               
                   
                   
                   
                   
                   
                 Contains CA repeat, STSs, GSSs and a CpG Island, complete sequence. 
               
               
                   
                   
                 GB_PL2: ATF21P8 
                 85785 
                 AL022347 
                   Arabidopsis thaliana  DNA chromosome 4, BAC clone F21P8 (ESSA project). 
                 
                   Arabidopsis thaliana 
                 
                 34,325 
                 9-Jun-99 
               
               
                   
                   
                 GB_PL2: U89959 
                 106973 
                 U89959 
                   Arabidopsis thaliana  BAC T7I23, complete sequence. 
                 
                   Arabidopsis thaliana 
                 
                 33,874 
                 26-Jun-98 
               
               
                 rxa02136 
                 645 
                 GB_PL2: ATAC005819 
                 57752 
                 AC005819 
                   Arabidopsis thaliana  chromosome II BAC T3A4 genomic sequence, complete 
                 
                   Arabidopsis thaliana 
                 
                 34,123 
                 3-Nov-98 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                   
                   
                 GB_PL2: F15K9 
                 71097 
                 AC005278 
                   Arabidopsis thaliana  chromosome 1 BAC F15K9 sequence, complete 
                 
                   Arabidopsis thaliana 
                 
                 31,260 
                 7-Nov-98 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                   
                   
                 GB_PL2: U89959 
                 106973 
                 U89959 
                   Arabidopsis thaliana  BAC T7I23, complete sequence. 
                 
                   Arabidopsis thaliana 
                 
                 34,281 
                 26-Jun-98 
               
               
                 rxa02139 
                 1962 
                 GB_BA1: MTCY190 
                 34150 
                 Z70283 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 98/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 62,904 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MSGB1554CS 
                 36548 
                 L78814 
                   Mycobacterium leprae  cosmid B1554 DNA sequence. 
                 
                   Mycobacterium leprae 
                 
                 36,648 
                 15-Jun-96 
               
               
                   
                   
                 GB_BA1: MSGB1551CS 
                 36548 
                 L78813 
                   Mycobacterium leprae  cosmid B1551 DNA sequence. 
                 
                   Mycobacterium leprae 
                 
                 36,648 
                 15-Jun-96 
               
               
                 rxa02153 
                 903 
                 GB_BA2: AF049897 
                 9196 
                 AF049897 
                   Corynebacterium glutamicum  N-acetylglutamylphosphate reductase (argC), 
                 
                   Corynebacterium glutamicum 
                 
                 99,104 
                 1-Jul-98 
               
               
                   
                   
                   
                   
                   
                 ornithine acetyltransferase (argJ), N-acetylglutamate kinase (argB), 
               
               
                   
                   
                   
                   
                   
                 acetylornithine transaminase (argD), ornithine carbamoyltransferase 
               
               
                   
                   
                   
                   
                   
                 (argF), arginine repressor (argR), argininosuccinate synthase (argG), and 
               
               
                   
                   
                   
                   
                   
                 argininosuccinate lyase (argH) genes, complete cds. 
               
               
                   
                   
                 GB_BA1: AF005242 
                 1044 
                 AF005242 
                   Corynebacterium glutamicum  N-acetylglutamate-5-semialdehyde 
                 
                   Corynebacterium glutamicum 
                 
                 99,224 
                 2-Jul-97 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase (argC) gene, complete cds. 
               
               
                   
                   
                 GB_BA1: CGARGCJBD 
                 4355 
                 X86157 
                   C. glutamicum  argC, argJ, argB, argD, and argF genes. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 25-Jul-96 
               
               
                 rxa02154 
                 414 
                 GB_BA2: AF049897 
                 9196 
                 AF049897 
                   Corynebacterium glutamicum  N-acetylglutamylphosphate reductase (argC), 
                 
                   Corynebacterium glutamicum 
                 
                 98,551 
                 1-Jul-98 
               
               
                   
                   
                   
                   
                   
                 ornithine acetyltransferase (argJ), N-acetylglutamate kinase (argB), 
               
               
                   
                   
                   
                   
                   
                 acetylornithine transaminase (argD), ornithine carbamoyltransferase (argF), 
               
               
                   
                   
                   
                   
                   
                 arginine repressor (argR), argininosuccinate synthase (argG), and 
               
               
                   
                   
                   
                   
                   
                 argininosuccinate lyase (argH) genes, complete cds. 
               
               
                   
                   
                 GB_BA1: AF005242 
                 1044 
                 AF005242 
                   Corynebacterium glutamicum  N-acetylglutamate-5-semialdehyde 
                 
                   Corynebacterium glutamicum 
                 
                 98,477 
                 2-Jul-97 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase (argC) gene, complete cds. 
               
               
                   
                   
                 GB_BA1: CGARGCJBD 
                 4355 
                 X86157 
                   C. glutamicum  argC, argJ, argB, argD, and argF genes. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 25-Jul-96 
               
               
                 rxa02155 
                 1287 
                 GB_BA1: CGARGCJBD 
                 4355 
                 X86157 
                   C. glutamicum  argC, argJ, argB, argD, and argF genes. 
                 
                   Corynebacterium glutamicum 
                 
                 99,767 
                 25-Jul-96 
               
               
                   
                   
                 GB_BA2: AF049897 
                 9196 
                 AF049897 
                   Corynebacterium glutamicum  N-acetylglutamylphosphate reductase (argC), 
                 
                   Corynebacterium glutamicum 
                 
                 99,378 
                 1-Jul-98 
               
               
                   
                   
                   
                   
                   
                 ornithine acetyltransferase (argJ), N-acetylglutamate kinase (argB), 
               
               
                   
                   
                   
                   
                   
                 acetylornithine transaminase (argD), ornithine carbamoyltransferase (argF), 
               
               
                   
                   
                   
                   
                   
                 arginine repressor (argR), argininosuccinate synthase (argG), and 
               
               
                   
                   
                   
                   
                   
                 argininosuccinate lyase (argH) genes, complete cds. 
               
               
                   
                   
                 GB_BA1: MSGB1133CS 
                 42106 
                 L78811 
                   Mycobacterium leprae  cosmid B1133 DNA sequence. 
                 
                   Mycobacterium leprae 
                 
                 55,504 
                 15-Jun-96 
               
               
                 rxa02156 
                 1074 
                 GB_BA2: AF049897 
                 9196 
                 AF049897 
                   Corynebacterium glutamicum  N-acetylglutamylphosphate reductase (argC), 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 1-Jul-98 
               
               
                   
                   
                   
                   
                   
                 ornithine acetyltransferase (argJ), N-acetylglutamate kinase (argB), 
               
               
                   
                   
                   
                   
                   
                 acetylornithine transaminase (argD), ornithine carbamoyltransferase (argF), 
               
               
                   
                   
                   
                   
                   
                 arginine repressor (argR), argininosuccinate synthase (argG), and 
               
               
                   
                   
                   
                   
                   
                 argininosuccinate lyase (argH) genes, complete cds. 
               
               
                   
                   
                 GB_BA1: CGARGCJBD 
                 4355 
                 X86157 
                   C. glutamicum  argC, argJ, argB, argD, and argF genes. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 25-Jul-96 
               
               
                   
                   
                 GB_BA2: AE001816 
                 10007 
                 AE001816 
                   Thermotoga maritima  section 128 of 136 of the complete genome. 
                 
                   Thermotoga maritima 
                 
                 50,238 
                 2-Jun-99 
               
               
                 rxa02157 
                 1296 
                 GB_BA2: AF049897 
                 9196 
                 AF049897 
                   Corynebacterium glutamicum  N-acetylglutamylphosphate reductase (argC), 
                 
                   Corynebacterium glutamicum 
                 
                 99,612 
                 1-Jul-98 
               
               
                   
                   
                   
                   
                   
                 ornithine acetyltransferase (argJ), N-acetylglutamate kinase (argB), 
               
               
                   
                   
                   
                   
                   
                 acetylornithine transaminase (argD), ornithine carbamoyltransferase (argF), 
               
               
                   
                   
                   
                   
                   
                 arginine repressor (argR), argininosuccinate synthase (argG), and 
               
               
                   
                   
                   
                   
                   
                 argininosuccinate lyase (argH) genes, complete cds. 
               
               
                   
                   
                 GB_BA1: CGARGCJBD 
                 4355 
                 X86157 
                   C. glutamicum  argC, argJ, argB, argD, and argF genes. 
                 
                   Corynebacterium glutamicum 
                 
                 99,612 
                 25-Jul-96 
               
               
                   
                   
                 GB_BA1: MTCY06H11 
                 38000 
                 Z85982 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 73/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 57,278 
                 17-Jun-98 
               
               
                 rxa02158 
                 1080 
                 GB_BA2: AF049897 
                 9196 
                 AF049897 
                   Corynebacterium glutamicum  N-acetylglutamylphosphate reductase (argC), 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 1-Jul-98 
               
               
                   
                   
                   
                   
                   
                 ornithine acetyltransferase (argJ), N-acetylglutamate kinase (argB), 
               
               
                   
                   
                   
                   
                   
                 acetylornithine transaminase (argD), ornithine carbamoyltransferase (argF), 
               
               
                   
                   
                   
                   
                   
                 arginine repressor (argR), argininosuccinate synthase (argG), and 
               
               
                   
                   
                   
                   
                   
                 argininosuccinate lyase (argH) genes, complete cds. 
               
               
                   
                   
                 GB_BA2: AF031518 
                 2045 
                 AF031518 
                   Corynebacterium glutamicum  ornithine carbamolytransferase (argF) gene, 
                 
                   Corynebacterium glutamicum 
                 
                 99,898 
                 5-Jan-99 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                 GB_BA1: CGARGCJBD 
                 4355 
                 X86157 
                   C. glutamicum  argC, argJ, argB, argD, and argF genes. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 25-Jul-96 
               
               
                 rxa02159 
                 636 
                 GB_BA2: AF049897 
                 9196 
                 AF049897 
                   Corynebacterium glutamicum  N-acetylglutamylphosphate reductase (argC), 
                 
                   Corynebacterium glutamicum 
                 
                 99,843 
                 1-Jul-98 
               
               
                   
                   
                   
                   
                   
                 ornithine acetyltransferase (argJ), N-acetylglutamate kinase (argB), 
               
               
                   
                   
                   
                   
                   
                 acetylornithine transaminase (argD), ornithine carbamoyltransferase (argF), 
               
               
                   
                   
                   
                   
                   
                 arginine repressor (argR), argininosuccinate synthase (argG), and 
               
               
                   
                   
                   
                   
                   
                 argininosuccinate lyase (argH) genes, complete cds. 
               
               
                   
                   
                 GB_BA2: AF031518 
                 2045 
                 AF031518 
                   Corynebacterium glutamicum  ornithine carbamolytransferase (argF) gene, 
                 
                   Corynebacterium glutamicum 
                 
                 88,679 
                 5-Jan-99 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                 GB_BA2: AF041436 
                 516 
                 AF041436 
                   Corynebacterium glutamicum  arginine repressor (argR) gene, complete cds. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 5-Jan-99 
               
               
                 rxa02160 
                 1326 
                 GB_BA2: AF049897 
                 9196 
                 AF049897 
                   Corynebacterium glutamicum  N-acetylglutamylphosphate reductase (argC), 
                 
                   Corynebacterium glutamicum 
                 
                 99,774 
                 1-Jul-98 
               
               
                   
                   
                   
                   
                   
                 ornithine acetyltransferase (argJ), N-acetylglutamate kinase (argB), 
               
               
                   
                   
                   
                   
                   
                 acetylornithine transaminase (argD), ornithine carbamoyltransferase (argF), 
               
               
                   
                   
                   
                   
                   
                 arginine repressor (argR), argininosuccinate synthase (argG), and 
               
               
                   
                   
                   
                   
                   
                 argininosuccinate lyase (argH) genes, complete cds. 
               
               
                   
                   
                 GB_BA2: AF030520 
                 1206 
                 AF030520 
                   Corynebacterium glutamicum  argininosuccinate synthetase (argG) gene, 
                 
                   Corynebacterium glutamicum 
                 
                 99,834 
                 19-Nov-97 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                 GB_BA1: SCARGGH 
                 1909 
                 Z49111 
                   S. clavuligerus  argG gene and argH gene (partial). 
                 
                   Streptomyces clavuligerus 
                 
                 65,913 
                 22-Apr-96 
               
               
                 rxa02162 
                 1554 
                 GB_BA2: AF049897 
                 9196 
                 AF049897 
                   Corynebacterium glutamicum  N-acetylglutamylphosphate reductase (argC), 
                 
                   Corynebacterium glutamicum 
                 
                 88,524 
                 1-Jul-98 
               
               
                   
                   
                   
                   
                   
                 ornithine acetyltransferase (argJ), N-acetylglutamate kinase (argB), 
               
               
                   
                   
                   
                   
                   
                 acetylornithine transaminase (argD), ornithine carbamoyltransferase (argF), 
               
               
                   
                   
                   
                   
                   
                 arginine repressor (argR), argininosuccinate synthase (argG), and 
               
               
                   
                   
                   
                   
                   
                 argininosuccinate lyase (argH) genes, complete cds. 
               
               
                   
                   
                 GB_BA2: AF048764 
                 1437 
                 AF048764 
                   Corynebacterium glutamicum  argininosuccinate lyase (argH) gene, complete 
                 
                   Corynebacterium glutamicum 
                 
                 87,561 
                 1-Jul-98 
               
               
                   
                   
                   
                   
                   
                 cds. 
               
               
                   
                   
                 GB_BA1: MTCY06H11 
                 38000 
                 Z85982 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 73/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 64,732 
                 17-Jun-98 
               
               
                 rxa02176 
                 1251 
                 GB_BA1: MTCY31 
                 37630 
                 Z73101 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 41/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 36,998 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: CGGLTG 
                 3013 
                 X66112 
                   C. glutamicum  glt gene for citrate synthase and ORF. 
                 
                   Corynebacterium glutamicum 
                 
                 39,910 
                 17-Feb-95 
               
               
                   
                   
                 GB_PL2: PGU65399 
                 2700 
                 U65399 
                   Basidiomycete  CECT 20197 phenoloxidase (pox1) gene, complete cds. 
                   basidiomycete  CECT 20197 
                 38,474 
                 19-Jul-97 
               
               
                 rxa02189 
                 861 
                 GB_PR3: AC002468 
                 115888 
                 AC002468 
                 Human Chromosome 15q26.1 PAC clone pDJ417d7, complete sequence. 
                 
                   Homo sapiens 
                 
                 35,941 
                 16-Sep-98 
               
               
                   
                   
                 GB_BA1: MSGB1970CS 
                 39399 
                 L78815 
                   Mycobacterium leprae  cosmid B1970 DNA sequence. 
                 
                   Mycobacterium leprae 
                 
                 40,286 
                 15-Jun-96 
               
               
                   
                   
                 GB_PR3: AC002468 
                 115888 
                 AC002468 
                 Human Chromosome 15q26.1 PAC clone pDJ417d7, complete sequence. 
                 
                   Homo sapiens 
                 
                 33,689 
                 16-Sep-98 
               
               
                 rxa02193 
                 1701 
                 GB_BA1: BRLASPA 
                 1987 
                 D25316 
                   Brevibacterium flavum  aspA gene for aspartase, complete cds. 
                 
                   Corynebacterium glutamicum 
                 
                 99,353 
                 6-Feb-99 
               
               
                   
                   
                 GB_PAT: E04307 
                 1581 
                 E04307 
                 DNA encoding  Brevibacterium flavum  aspartase. 
                 
                   Corynebacterium glutamicum 
                 
                 99,367 
                 29-Sep-97 
               
               
                   
                   
                 GB_BA1: ECOUW93 
                 338534 
                 U14003 
                   Escherichia coli  K-12 chromosomal region from 92.8 to 00.1 minutes. 
                 
                   Escherichia coli 
                 
                 37,651 
                 17-Apr-96 
               
               
                 rxa02194 
                 966 
                 GB_BA2: AF050166 
                 840 
                 AF050166 
                   Corynebacterium glutamicum  ATP phosphoribosyltransferase (hisG) gene, 
                 
                   Corynebacterium glutamicum 
                 
                 98,214 
                 5-Jan-99 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                 GB_BA1: BRLASPA 
                 1987 
                 D25316 
                   Brevibacterium flavum  aspA gene for aspartase, complete cds. 
                 
                   Corynebacterium glutamicum 
                 
                 93,805 
                 6-Feb-99 
               
               
                   
                   
                 GB_PAT: E08649 
                 188 
                 E08649 
                 DNA encoding part of aspartase from coryneform bacteria. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 29-Sep-97 
               
               
                 rxa02195 
                 393 
                 GB_BA2: AF086704 
                 264 
                 AF086704 
                   Corynebacterium glutamicum  phosphoribosyl-ATP-pyrophosphohydrolase 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 8-Feb-99 
               
               
                   
                   
                   
                   
                   
                 (hisE) gene, complete cds. 
               
               
                   
                   
                 GB_BA1: EAY17145 
                 6019 
                 Y17145 
                   Eubacterium acidaminophilum  grdR, grdI, grdH genes and partial ldc, grdT 
                 
                   Eubacterium acidaminophilum 
                 
                 39,075 
                 5-Aug-98 
               
               
                   
                   
                   
                   
                   
                 genes. 
               
               
                   
                   
                 GB_STS: G01195 
                 332 
                 G01195 
                 fruit fly STS Dm1930 clone DS06959 T7. 
                 
                   Drosophila melanogaster 
                 
                 35,542 
                 28-Feb-95 
               
               
                 rxa02197 
                 551 
                 GB_BA1: MTCY261 
                 27322 
                 Z97559 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 95/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 33,938 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MLCB2533 
                 40245 
                 AL035310 
                   Mycobacterium leprae  cosmid B2533. 
                 
                   Mycobacterium leprae 
                 
                 65,517 
                 27-Aug-99 
               
               
                   
                   
                 GB_BA1: U00017 
                 42157 
                 U00017 
                   Mycobacterium leprae  cosmid B2126. 
                 
                   Mycobacterium leprae 
                 
                 36,770 
                 01-MAR-1994 
               
               
                 rxa02198 
                 2599 
                 GB_BA1: U00017 
                 42157 
                 U00017 
                   Mycobacterium leprae  cosmid B2126. 
                 
                   Mycobacterium leprae 
                 
                 38,674 
                 01-MAR-1994 
               
               
                   
                   
                 GB_BA1: MLCB2533 
                 40245 
                 AL035310 
                   Mycobacterium leprae  cosmid B2533. 
                 
                   Mycobacterium leprae 
                 
                 65,465 
                 27-Aug-99 
               
               
                   
                   
                 GB_BA1: MTCY261 
                 27322 
                 Z97559 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 95/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 37,577 
                 17-Jun-98 
               
               
                 rxa02208 
                 1025 
                 GB_BA1: U00017 
                 42157 
                 U00017 
                   Mycobacterium leprae  cosmid B2126. 
                 
                   Mycobacterium leprae 
                 
                 59,823 
                 01-MAR-1994 
               
               
                   
                   
                 GB_BA1: AP000063 
                 185300 
                 AP000063 
                   Aeropyrum pernix  genomic DNA, section 6/7. 
                 
                   Aeropyrum pernix 
                 
                 39,442 
                 22-Jun-99 
               
               
                   
                   
                 GB_PR4: AC006236 
                 127593 
                 AC006236 
                   Homo sapiens  chromosome 17, clone hCIT.162_E_12, complete sequence. 
                 
                   Homo sapiens 
                 
                 37,191 
                 29-DEC-1998 
               
               
                 rxa02229 
                 948 
                 GB_BA1: MSGY154 
                 40221 
                 AD000002 
                   Mycobacterium tuberculosis  sequence from clone y154. 
                 
                   Mycobacterium tuberculosis 
                 
                 53,541 
                 03-DEC-1996 
               
               
                   
                   
                 GB_BA1: MTCY154 
                 13935 
                 Z98209 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 121/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 40,407 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: U00019 
                 36033 
                 U00019 
                   Mycobacterium leprae  cosmid B2235. 
                 
                   Mycobacterium leprae 
                 
                 40,541 
                 01-MAR-1994 
               
               
                 rxa02234 
                 3462 
                 GB_BA1: MSGB937CS 
                 38914 
                 L78820 
                   Mycobacterium leprae  cosmid B937 DNA sequence. 
                 
                   Mycobacterium leprae 
                 
                 66,027 
                 15-Jun-96 
               
               
                   
                   
                 GB_BA1: MTCY2B12 
                 20431 
                 Z81011 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 61/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 71,723 
                 18-Jun-98 
               
               
                   
                   
                 GB_BA2: U01072 
                 4393 
                 U01072 
                   Mycobacterium bovis  BCG orotidine-5′-monophosphate decarboxylase (uraA) 
                 
                   Mycobacterium bovis 
                 
                 67,101 
                 22-DEC-1993 
               
               
                   
                   
                   
                   
                   
                 gene. 
               
               
                 rxa02235 
                 727 
                 GB_BA1: MSU91572 
                 960 
                 U91572 
                   Mycobacterium smegmatis  carbamoyl phosphate synthetase (pyrAB) gene, 
                 
                   Mycobacterium smegmatis 
                 
                 60,870 
                 22-MAR-1997 
               
               
                   
                   
                   
                   
                   
                 partial cds and orotidine 5′-monophosphate decarboxylase (pyrF) gene, 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                 GB_HTG3: AC009364 
                 192791 
                 AC009364 
                   Homo sapiens  chromosome 7, *** SEQUENCING IN PROGRESS ***, 57 
                 
                   Homo sapiens 
                 
                 37,994 
                 1-Sep-99 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                   
                   
                 GB_HTG3: AC009364 
                 192791 
                 AC009364 
                   Homo sapiens chromosome  7, *** SEQUENCING IN PROGRESS ***, 57 
                 
                   Homo sapiens 
                 
                 37,994 
                 1-Sep-99 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                 rxa02237 
                 693 
                 GB_BA1: MTCY21B4 
                 39150 
                 Z80108 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 62/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 55,844 
                 23-Jun-98 
               
               
                   
                   
                 GB_BA2: AF077324 
                 5228 
                 AF077324 
                   Rhodococcus equi  strain 103 plasmid RE-VP1 fragment f. 
                 
                   Rhodococcus equi 
                 
                 41,185 
                 5-Nov-98 
               
               
                   
                   
                 GB_EST22: AU017763 
                 586 
                 AU017763 
                 AU017763 Mouse two-cell stage embryo cDNA  Mus musculus  cDNA clone 
                 
                   Mus musculus 
                 
                 38,616 
                 19-OCT-1998 
               
               
                   
                   
                   
                   
                   
                 J0744A04 3′, mRNA sequence. 
               
               
                 rxa02239 
                 1389 
                 GB_BA1: MTCY21B4 
                 39150 
                 Z80108 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 62/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 56,282 
                 23-Jun-98 
               
               
                   
                   
                 GB_HTG3: AC010745 
                 193862 
                 AC010745 
                   Homo sapiens  clone NH0549D18, *** SEQUENCING IN PROGRESS ***, 30 
                 
                   Homo sapiens 
                 
                 36,772 
                 21-Sep-99 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                   
                   
                 GB_HTG3: AC010745 
                 193862 
                 AC010745 
                   Homo sapiens  clone NH0549D18, *** SEQUENCING IN PROGRESS ***, 30 
                 
                   Homo sapiens 
                 
                 36,772 
                 21-Sep-99 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                 rxa02240 
                 1344 
                 EM_PAT: E09855 
                 1239 
                 E09855 
                 gDNA encoding S-adenosylmethionine synthetase. 
                 
                   Corynebacterium glutamicum 
                 
                 99,515 
                 07-OCT-1997 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 (Rel. 52, 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Created) 
               
               
                   
                   
                 GB_PAT: A37831 
                 5392 
                 A37831 
                 Sequence 1 from Patent WO9408014. 
                 
                   Streptomyces pristinaespiralis 
                 
                 63,568 
                 05-MAR-1997 
               
               
                   
                   
                 GB_BA2: AF117274 
                 2303 
                 AF117274 
                   Streptomyces spectabilis  flavoprotein homolog Dfp (dfp) gene, partial cds; and 
                 
                   Streptomyces spectabilis 
                 
                 65,000 
                 31-MAR-1999 
               
               
                   
                   
                   
                   
                   
                 S-adenosylmethionine synthetase (metK) gene, complete cds. 
               
               
                 rxa02246 
                 1107 
                 EM_BA1: AB003693 
                 5589 
                 AB003693 
                   Corynebacterium ammoniagenes  DNA for rib operon, complete cds. 
                 
                   Corynebacterium 
                 
                 52,909 
                 03-OCT-1997 
               
               
                   
                   
                   
                   
                   
                   
                 
                   ammoniagenes 
                 
                   
                 (Rel. 52, 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Created) 
               
               
                   
                   
                 GB_PAT: E07957 
                 5589 
                 E07957 
                 gDNA encoding at least guanosine triphosphate cyclohydrolase and riboflavin 
                 
                   Corynebacterium 
                 
                 52,909 
                 29-Sep-97 
               
               
                   
                   
                   
                   
                   
                 synthase. 
                 
                   ammoniagenes 
                 
               
               
                   
                   
                 GB_PAT: I32742 
                 5589 
                 I32742 
                 Sequence 1 from patent U.S. Pat. No. 5589355. 
                 Unknown. 
                 52,909 
                 6-Feb-97 
               
               
                 rxa02247 
                 756 
                 GB_PAT: I32743 
                 2689 
                 I32743 
                 Sequence 2 from patent U.S. Pat. No. 5589355. 
                 Unknown. 
                 57,937 
                 6-Feb-97 
               
               
                   
                   
                 EM_BA1: AB003693 
                 5589 
                 AB003693 
                   Corynebacterium ammoniagenes  DNA for rib operon, complete cds. 
                 
                   Corynebacterium 
                 
                 57,937 
                 03-OCT-1997 
               
               
                   
                   
                   
                   
                   
                   
                 
                   ammoniagenes 
                 
                   
                 (Rel. 52, 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Created) 
               
               
                   
                   
                 GB_PAT: I32742 
                 5589 
                 I32742 
                 Sequence 1 from patent U.S. Pat. No. 5589355. 
                 Unknown. 
                 57,937 
                 6-Feb-97 
               
               
                 rxa02248 
                 1389 
                 GB_PAT: I32742 
                 5589 
                 I32742 
                 Sequence 1 from patent U.S. Pat. No. 5589355. 
                 Unknown. 
                 61,843 
                 6-Feb-97 
               
               
                   
                   
                 EM_BA1: AB003693 
                 5589 
                 AB003693 
                   Corynebacterium ammoniagenes  DNA for rib operon, complete cds. 
                 
                   Corynebacterium 
                 
                 61,843 
                 03-OCT-1997 
               
               
                   
                   
                   
                   
                   
                   
                 
                   ammoniagenes 
                 
                   
                 (Rel. 52, 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Created) 
               
               
                   
                   
                 GB_PAT: E07957 
                 5589 
                 E07957 
                 gDNA encoding at least guanosine triphosphate cyclohydrolase and riboflavin 
                 
                   Corynebacterium 
                 
                 61,843 
                 29-Sep-97 
               
               
                   
                   
                   
                   
                   
                 synthase. 
                 
                   ammoniagenes 
                 
               
               
                 rxa02249 
                 600 
                 GB_PAT: E07957 
                 5589 
                 E07957 
                 gDNA encoding at least guanosine triphosphate cyclohydrolase and riboflavin 
                 
                   Corynebacterium 
                 
                 64,346 
                 29-Sep-97 
               
               
                   
                   
                   
                   
                   
                 synthase. 
                 
                   ammoniagenes 
                 
               
               
                   
                   
                 GB_PAT: I32742 
                 5589 
                 I32742 
                 Sequence 1 from patent U.S. Pat. No. 5589355. 
                 Unknown. 
                 64,346 
                 6-Feb-97 
               
               
                   
                   
                 GB_PAT: I32743 
                 2689 
                 I32743 
                 Sequence 2 from patent U.S. Pat. No. 5589355. 
                 Unknown. 
                 64,346 
                 6-Feb-97 
               
               
                 rxa02250 
                 643 
                 GB_PAT: E07957 
                 5589 
                 E07957 
                 gDNA encoding at least guanosine triphosphate cyclohydrolase and riboflavin 
                 
                   Corynebacterium 
                 
                 56,318 
                 29-Sep-97 
               
               
                   
                   
                   
                   
                   
                 synthase. 
                 
                   ammoniagenes 
                 
               
               
                   
                   
                 GB_PAT: I32742 
                 5589 
                 I32742 
                 Sequence 1 from patent U.S. Pat. No. 5589355. 
                 Unknown. 
                 56,318 
                 6-Feb-97 
               
               
                   
                   
                 EM_BA1: AB003693 
                 5589 
                 AB003693 
                   Corynebacterium ammoniagenes  DNA for rib operon, complete cds. 
                 
                   Corynebacterium 
                 
                 56,318 
                 03-OCT-1997 
               
               
                   
                   
                   
                   
                   
                   
                 
                   ammoniagenes 
                 
                   
                 (Rel. 52, 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Created) 
               
               
                 rxa02262 
                 1269 
                 GB_BA1: CGL007732 
                 4460 
                 AJ007732 
                   Corynebacterium glutamicum  3′ ppc gene, secG gene, amt gene, ocd gene 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 7-Jan-99 
               
               
                   
                   
                   
                   
                   
                 and 5′ soxA gene. 
               
               
                   
                   
                 GB_BA1: CGAMTGENE 
                 2028 
                 X93513 
                   C. glutamicum  amt gene. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 29-MAY-1996 
               
               
                   
                   
                 GB_VI: HEHCMVCG 
                 229354 
                 X17403 
                 Human cytomegalovirus strain AD169 complete genome. 
                 human herpesvirus 5 
                 38,651 
                 10-Feb-99 
               
               
                 rxa02263 
                 488 
                 GB_BA1: CGL007732 
                 4460 
                 AJ007732 
                   Corynebacterium glutamicum  3′ ppc gene, secG gene, amt gene, ocd gene 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 7-Jan-99 
               
               
                   
                   
                   
                   
                   
                 and 5′ soxA gene. 
               
               
                   
                   
                 GB_BA1: CGL007732 
                 4460 
                 AJ007732 
                   Corynebacterium glutamicum  3′ ppc gene, secG gene, amt gene, ocd gene 
                 
                   Corynebacterium glutamicum 
                 
                 37,526 
                 7-Jan-99 
               
               
                   
                   
                   
                   
                   
                 and 5′ soxA gene. 
               
               
                 rxa02272 
                 1368 
                 EM_PAT: E09373 
                 1591 
                 E09373 
                   Creatinine deiminase  gene. 
                   Bacillus  sp. 
                 96,928 
                 08-OCT-1997 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 (Rel. 52, 
               
               
                   
                   
                   
                   
                   
                   
                   
                   
                 Created) 
               
               
                   
                   
                 GB_BA1: D38505 
                 1591 
                 D38505 
                   Bacillus  sp. gene for creatinine deaminase, complete cds. 
                   Bacillus  sp. 
                 96,781 
                 7-Aug-98 
               
               
                   
                   
                 GB_HTG2: AC006595 
                 146070 
                 AC006595 
                   Homo sapiens , *** SEQUENCING IN PROGRESS ***, 4 unordered pieces. 
                 
                   Homo sapiens 
                 
                 36,264 
                 20-Feb-99 
               
               
                 rxa02281 
                 1545 
                 GB_GSS12: AQ411010 
                 551 
                 AQ411010 
                 HS_2257_B1_H02_MR CIT Approved Human Genomic Sperm Library D 
                 
                   Homo sapiens 
                 
                 36,197 
                 17-MAR-1999 
               
               
                   
                   
                   
                   
                   
                   Homo sapiens  genomic clone Plate = 2257 Col = 3 Row = P, genomic survey 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                   
                   
                 GB_EST23: AI128623 
                 363 
                 AI128623 
                 qa62c01.s1 Soares_fetal_heart_NbHH19W  Homo sapiens  cDNA clone 
                 
                   Homo sapiens 
                 
                 37,017 
                 05-OCT-1998 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 1691328 3′, mRNA sequence. 
               
               
                   
                   
                 GB_PL2: ATAC007019 
                 102335 
                 AC007019 
                   Arabidopsis thaliana  chromosome II BAC F7D8 genomic sequence, complete 
                 
                   Arabidopsis thaliana 
                 
                 33,988 
                 16-MAR-1999 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                 rxa02299 
                 531 
                 GB_BA2: AF116184 
                 540 
                 AF116184 
                   Corynebacterium glutamicum  L-aspartate-alpha-decarboxylase precursor 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 02-MAY-1999 
               
               
                   
                   
                   
                   
                   
                 (panD) gene, complete cds. 
               
               
                   
                   
                 GB_GSS9: AQ164310 
                 507 
                 AQ164310 
                 HS_2171_A2_E01_MR CIT Approved Human Genomic Sperm Library D 
                 
                   Homo sapiens 
                 
                 37,278 
                 16-OCT-1998 
               
               
                   
                   
                   
                   
                   
                   Homo sapiens  genomic clone Plate = 2171 Col = 2 Row = I, genomic survey 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                   
                   
                 GB_VI: MH68TKH 
                 4557 
                 X93468 
                 Murine herpesvirus type 68 thymidine kinase and glycoprotein H genes. 
                 murine herpesvirus 68 
                 40,288 
                 3-Sep-96 
               
               
                 rxa02311 
                 813 
                 GB_HTG4: AC006091 
                 176878 
                 AC006091 
                   Drosophila melanogaster  chromosome 3 clone BACR48G05 (D475) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 36,454 
                 27-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 48.G.5 map 91F1-91F13 strain y; cn bw sp, *** SEQUENCING IN PROGRESS 
               
               
                   
                   
                   
                   
                   
                 ***, 4 unordered pieces. 
               
               
                   
                   
                 GB_HTG4: AC006091 
                 176878 
                 AC006091 
                   Drosophila melanogaster  chromosome 3 clone BACR48G05 (D475) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 36,454 
                 27-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 48.G.5 map 91F1-91F13 strain y; cn bw sp, *** SEQUENCING IN PROGRESS 
               
               
                   
                   
                   
                   
                   
                 ***, 4 unordered pieces. 
               
               
                   
                   
                 GB_BA2: RRU65510 
                 16259 
                 U65510 
                   Rhodospirillum rubrum  CO-induced hydrogenase operon (cooM, cooK, cooL, 
                 
                   Rhodospirillum rubrum 
                 
                 37,828 
                 9-Apr-97 
               
               
                   
                   
                   
                   
                   
                 cooX, cooU, cooH) genes, iron sulfur protein (cooF) gene, carbon monoxide 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase (cooS) gene, carbon monoxide dehydrogenase 
               
               
                   
                   
                   
                   
                   
                 accessory proteins (cooC, cooT, cooJ) genes, putative transcriptional activator 
               
               
                   
                   
                   
                   
                   
                 (cooA) gene, nicotinate-nucleotide pyrophosphorylase (nadC) gene, complete 
               
               
                   
                   
                   
                   
                   
                 cds, L-aspartate oxidase (nadB) gene, and alkyl hydroperoxide 
               
               
                   
                   
                   
                   
                   
                 reductase (ahpC) gene, partial cds. 
               
               
                 rxa02315 
                 1752 
                 GB_BA1: MSGY224 
                 40051 
                 AD000004 
                   Mycobacterium tuberculosis  sequence from clone y224. 
                 
                   Mycobacterium tuberculosis 
                 
                 49,418 
                 03-DEC-1996 
               
               
                   
                   
                 GB_BA1: MTY25D10 
                 40838 
                 Z95558 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 28/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 49,360 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MSGY224 
                 40051 
                 AD000004 
                   Mycobacterium tuberculosis  sequence from clone y224. 
                 
                   Mycobacterium tuberculosis 
                 
                 38,150 
                 03-DEC-1996 
               
               
                 rxa02318 
                 402 
                 GB_HTG3: AC011348 
                 111083 
                 AC011348 
                   Homo sapiens  chromosome 5 clone CIT-HSPC_303E13, *** SEQUENCING 
                 
                   Homo sapiens 
                 
                 35,821 
                 06-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 IN PROGRESS ***, 3 ordered pieces. 
               
               
                   
                   
                 GB_HTG3: AC011348 
                 111083 
                 AC011348 
                   Homo sapiens  chromosome 5 clone CIT-HSPC_303E13, *** SEQUENCING 
                 
                   Homo sapiens 
                 
                 35,821 
                 06-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 IN PROGRESS ***, 3 ordered pieces. 
               
               
                   
                   
                 GB_HTG3: AC011412 
                 89234 
                 AC011412 
                   Homo sapiens  chromosome 5 clone CIT978SKB_81K21, *** SEQUENCING 
                 
                   Homo sapiens 
                 
                 36,181 
                 06-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 IN PROGRESS ***, 3 ordered pieces. 
               
               
                 rxa02319 
                 1080 
                 GB_BA1: MSGY224 
                 40051 
                 AD000004 
                   Mycobacterium tuberculosis  sequence from clone y224. 
                 
                   Mycobacterium tuberculosis 
                 
                 37,792 
                 03-DEC-1996 
               
               
                   
                   
                 GB_BA1: MTY25D10 
                 40838 
                 Z95558 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 28/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 37,792 
                 17-Jun-98 
               
               
                   
                   
                 GB_EST23: AI117213 
                 476 
                 AI117213 
                 ub83h02.r1 Soares 2NbMT  Mus musculus  cDNA clone IMAGE: 1395123 
                 
                   Mus musculus 
                 
                 35,084 
                 2-Sep-98 
               
               
                   
                   
                   
                   
                   
                 5′, mRNA sequence. 
               
               
                 rxa02345 
                 1320 
                 GB_BA1: BAPURKE 
                 2582 
                 X91189 
                   B. ammoniagenes  purK and purE genes. 
                 
                   Corynebacterium 
                 
                 61,731 
                 14-Jan-97 
               
               
                   
                   
                   
                   
                   
                   
                 
                   ammoniagenes 
                 
               
               
                   
                   
                 GB_BA1: MTCY71 
                 42729 
                 Z92771 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 141/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 39,624 
                 10-Feb-99 
               
               
                   
                   
                 GB_BA1: MTCY71 
                 42729 
                 Z92771 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 141/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 39,847 
                 10-Feb-99 
               
               
                 rxa02350 
                 618 
                 GB_BA1: BAPURKE 
                 2582 
                 X91189 
                   B. ammoniagenes  purK and purE genes. 
                 
                   Corynebacterium 
                 
                 64,286 
                 14-Jan-97 
               
               
                   
                   
                   
                   
                   
                   
                 
                   ammoniagenes 
                 
               
               
                   
                   
                 GB_PL1: SC130KBXV 
                 129528 
                 X94335 
                   S. cerevisiae  130 kb DNA fragment from chromosome XV. 
                 
                   Saccharomyces cerevisiae 
                 
                 36,617 
                 15-Jul-97 
               
               
                   
                   
                 GB_PL1: SCXVORFS 
                 50984 
                 X90518 
                   S. cerevisiae  DNA of 51 Kb from chromosome XV right arm. 
                 
                   Saccharomyces cerevisiae 
                 
                 36,617 
                 1-Nov-95 
               
               
                 rxa02373 
                 1038 
                 GB_PAT: E00311 
                 1853 
                 E00311 
                 DNA coding of 2,5-diketogluconic acid reductase. 
                 unidentified 
                 56,123 
                 29-Sep-97 
               
               
                   
                   
                 GB_PAT: I06030 
                 1853 
                 I06030 
                 Sequence 4 from Patent EP 0305608. 
                 Unknown. 
                 56,220 
                 02-DEC-1994 
               
               
                   
                   
                 GB_PAT: I00836 
                 1853 
                 I00836 
                 Sequence 1 from Patent U.S. Pat. No. 4758514. 
                 Unknown. 
                 56,220 
                 21-MAY-1993 
               
               
                 rxa02375 
                 1350 
                 GB_BA2: CGU31230 
                 3005 
                 U31230 
                   Corynebacterium glutamicum  Obg protein homolog gene, partial cds, gamma 
                 
                   Corynebacterium glutamicum 
                 
                 99,332 
                 2-Aug-96 
               
               
                   
                   
                   
                   
                   
                 glutamyl kinase (proB) gene, complete cds, and (unkdh) gene, complete cds. 
               
               
                   
                   
                 GB_HTG3: AC009946 
                 169072 
                 AC009946 
                   Homo sapiens  clone NH0012C17, *** SEQUENCING IN PROGRESS ***, 1 
                 
                   Homo sapiens 
                 
                 36,115 
                 8-Sep-99 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                   
                   
                 GB_HTG3: AC009946 
                 169072 
                 AC009946 
                   Homo sapiens  clone NH0012C17, *** SEQUENCING IN PROGRESS ***, 1 
                 
                   Homo sapiens 
                 
                 36,115 
                 8-Sep-99 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                 rxa02380 
                 777 
                 GB_BA1: MTCY253 
                 41230 
                 Z81368 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 106/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 38,088 
                 17-Jun-98 
               
               
                   
                   
                 GB_HTG4: AC010658 
                 120754 
                 AC010658 
                   Drosophila melanogaster  chromosome 3L/75C1 clone RPCI98-3B20, *** 
                 
                   Drosophila melanogaster 
                 
                 35,817 
                 16-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 SEQUENCING IN PROGRESS ***, 78 unordered pieces. 
               
               
                   
                   
                 GB_HTG4: AC010658 
                 120754 
                 AC010658 
                   Drosophila melanogaster  chromosome 3L/75C1 clone RPCI98-3B20, *** 
                 
                   Drosophila melanogaster 
                 
                 35,817 
                 16-OCT-1999 
               
               
                   
                   
                   
                   
                   
                 SEQUENCING IN PROGRESS ***, 78 unordered pieces. 
               
               
                 rxa02382 
                 1419 
                 GB_BA1: CGPROAGEN 
                 1783 
                 X82929 
                   C. glutamicum  proA gene. 
                 
                   Corynebacterium glutamicum 
                 
                 98,802 
                 23-Jan-97 
               
               
                   
                   
                 GB_BA1: MTCY428 
                 26914 
                 Z81451 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 107/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 38,054 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA2: CGU31230 
                 3005 
                 U31230 
                   Corynebacterium glutamicum  Obg protein homolog gene, partial cds, gamma 
                 
                   Corynebacterium glutamicum 
                 
                 98,529 
                 2-Aug-96 
               
               
                   
                   
                   
                   
                   
                 glutamyl kinase (proB) gene, complete cds, and (unkdh) gene, complete cds. 
               
               
                 rxa02400 
                 693 
                 GB_BA1: CGACEA 
                 2427 
                 X75504 
                   C. glutamicum  aceA gene and thiX genes (partial). 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 9-Sep-94 
               
               
                   
                   
                 GB_PAT: I86191 
                 2135 
                 I86191 
                 Sequence 3 from patent U.S. Pat. No. 5700661. 
                 Unknown. 
                 100,000 
                 10-Jun-98 
               
               
                   
                   
                 GB_PAT: I13693 
                 2135 
                 I13693 
                 Sequence 3 from patent U.S. Pat. No. 5439822. 
                 Unknown. 
                 100,000 
                 26-Sep-95 
               
               
                 rxa02432 
                 1098 
                 GB_GSS15: AQ606842 
                 574 
                 AQ606842 
                 HS_5404_B2_E07_T7A RPCI-11 Human Male BAC Library  Homo sapiens   
                 
                   Homo sapiens 
                 
                 39,716 
                 10-Jun-99 
               
               
                   
                   
                   
                   
                   
                 genomic clone Plate = 980 Col = 14 Row = J, genomic survey sequence. 
               
               
                   
                   
                 GB_EST1: T05804 
                 406 
                 T05804 
                 EST03693 Fetal brain, Stratagene (cat#936206)  Homo sapiens  cDNA clone 
                 
                   Homo sapiens 
                 
                 37,915 
                 30-Jun-93 
               
               
                   
                   
                   
                   
                   
                 HFBDG63 similar to EST containing Alu repeat, mRNA sequence. 
               
               
                   
                   
                 GB_PL1: AB006699 
                 77363 
                 AB006699 
                   Arabidopsis thaliana  genomic DNA, chromosome 5, P1 clone: MDJ22, 
                 
                   Arabidopsis thaliana 
                 
                 35,526 
                 20-Nov-99 
               
               
                   
                   
                   
                   
                   
                 complete sequence. 
               
               
                 rxa02458 
                 1413 
                 GB_BA2: AF114233 
                 1852 
                 AF114233 
                   Corynebacterium glutamicum  5-enolpyruvylshikimate 3-phosphate synthase 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 7-Feb-99 
               
               
                   
                   
                   
                   
                   
                 (aroA) gene, complete cds. 
               
               
                   
                   
                 GB_EST37: AW013061 
                 578 
                 AW013061 
                 ODT-0033 Winter flounder ovary  Pleuronectes americanus  cDNA clone ODT- 
                 
                   Pleuronectes americanus 
                 
                 39,175 
                 10-Sep-99 
               
               
                   
                   
                   
                   
                   
                 0033 5′ similar to FRUCTOSE-BISPHOSPHATE ALDOLASE B (LIVER), 
               
               
                   
                   
                   
                   
                   
                 mRNA sequence. 
               
               
                   
                   
                 GB_GSS15: AQ650027 
                 728 
                 AQ650027 
                 Sheared DNA-5L2.TF Sheared DNA  Trypanosoma brucei  genomic clone 
                 
                   Trypanosoma brucei 
                 
                 39,281 
                 22-Jun-99 
               
               
                   
                   
                   
                   
                   
                 Sheared DNA-5L2, genomic survey sequence. 
               
               
                 rxa02469 
                 1554 
                 GB_BA1: MTCY359 
                 36021 
                 Z83859 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 84/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 39,634 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MLCB1788 
                 39228 
                 AL008609 
                   Mycobacterium leprae  cosmid B1788. 
                 
                   Mycobacterium leprae 
                 
                 59,343 
                 27-Aug-99 
               
               
                   
                   
                 GB_BA1: SCAJ10601 
                 4692 
                 AJ010601 
                   Streptomyces coelicolor  A3(2) DNA for whiD and whiK loci. 
                 
                   Streptomyces coelicolor 
                 
                 48,899 
                 17-Sep-98 
               
               
                 rxa02497 
                 1050 
                 GB_BA2: CGU31224 
                 422 
                 U31224 
                   Corynebacterium glutamicum  (ppx) gene, partial cds. 
                 
                   Corynebacterium glutamicum 
                 
                 96,445 
                 2-Aug-96 
               
               
                   
                   
                 GB_BA1: MTCY20G9 
                 37218 
                 Z77162 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 25/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 59,429 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: SCE7 
                 16911 
                 AL049819 
                   Streptomyces coelicolor  cosmid E7. 
                 
                   Streptomyces coelicolor 
                 
                 39,510 
                 10-MAY-1999 
               
               
                 rxa02499 
                 933 
                 GB_BA2: CGU31225 
                 1817 
                 U31225 
                   Corynebacterium glutamicum  L-proline: NADP+ 5-oxidoreductase (proC) gene, 
                 
                   Corynebacterium glutamicum 
                 
                 97,749 
                 2-Aug-96 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                   
                   
                 GB_BA1: NG17PILA 
                 1920 
                 X13965 
                   Neisseria gonorrhoeae  pilA gene. 
                 
                   Neisseria gonorrhoeae 
                 
                 43,249 
                 30-Sep-93 
               
               
                   
                   
                 GB_HTG2: AC007984 
                 129715 
                 AC007984 
                   Drosophila melanogaster  chromosome 3 clone BACR05C10 (D781) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 33,406 
                 2-Aug-99 
               
               
                   
                   
                   
                   
                   
                 05.C.10 map 97D-97E strain y; cn bw sp, *** SEQUENCING IN PROGRESS 
               
               
                   
                   
                   
                   
                   
                 ***, 87 unordered pieces. 
               
               
                 rxa02501 
                 1188 
                 GB_BA1: MTCY20G9 
                 37218 
                 Z77162 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 25/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 39,357 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: U00018 
                 42991 
                 U00018 
                   Mycobacterium leprae  cosmid B2168. 
                 
                   Mycobacterium leprae 
                 
                 51,768 
                 01-MAR-1994 
               
               
                   
                   
                 GB_VI: HE1CG 
                 152261 
                 X14112 
                 Herpes simplex virus (HSV) type 1 complete genome. 
                 
                   human herpesvirus 1 
                 
                 39,378 
                 17-Apr-97 
               
               
                 rxa02503 
                 522 
                 GB_PR3: AC005328 
                 35414 
                 AC005328 
                   Homo sapiens  chromosome 19, cosmid R26660, complete sequence. 
                 
                   Homo sapiens 
                 
                 39,922 
                 28-Jul-98 
               
               
                   
                   
                 GB_PR3: AC005545 
                 43514 
                 AC005545 
                   Homo sapiens  chromosome 19, cosmid R26634, complete sequence. 
                 
                   Homo sapiens 
                 
                 39,922 
                 3-Sep-98 
               
               
                   
                   
                 GB_PR3: AC005328 
                 35414 
                 AC005328 
                   Homo sapiens  chromosome 19, cosmid R26660, complete sequence. 
                 
                   Homo sapiens 
                 
                 34,911 
                 28-Jul-98 
               
               
                 rxa02504 
                 681 
                 GB_BA1: MTCY20G9 
                 37218 
                 Z77162 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 25/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 54,940 
                 17-Jun-98 
               
               
                   
                   
                 GB_PR3: AC005328 
                 35414 
                 AC005328 
                   Homo sapiens  chromosome 19, cosmid R26660, complete sequence. 
                 
                   Homo sapiens 
                 
                 41,265 
                 28-Jul-98 
               
               
                   
                   
                 GB_PR3: AC005545 
                 43514 
                 AC005545 
                   Homo sapiens  chromosome 19, cosmid R26634, complete sequence. 
                 
                   Homo sapiens 
                 
                 41,265 
                 3-Sep-98 
               
               
                 rxa02516 
                 1386 
                 GB_BA1: MLCL536 
                 36224 
                 Z99125 
                   Mycobacterium leprae  cosmid L536. 
                 
                   Mycobacterium leprae 
                 
                 37,723 
                 04-DEC-1998 
               
               
                   
                   
                 GB_BA1: U00013 
                 35881 
                 U00013 
                   Mycobacterium leprae  cosmid B1496. 
                 
                   Mycobacterium leprae 
                 
                 37,723 
                 01-MAR-1994 
               
               
                   
                   
                 GB_BA1: MTV007 
                 32806 
                 AL021184 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 64/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 61,335 
                 17-Jun-98 
               
               
                 rxa02517 
                 570 
                 GB_BA1: MLCL536 
                 36224 
                 Z99125 
                   Mycobacterium leprae  cosmid L536. 
                 
                   Mycobacterium leprae 
                 
                 37,018 
                 04-DEC-1998 
               
               
                   
                   
                 GB_BA1: U00013 
                 35881 
                 U00013 
                   Mycobacterium leprae  cosmid B1496. 
                 
                   Mycobacterium leprae 
                 
                 37,018 
                 01-MAR-1994 
               
               
                   
                   
                 GB_BA1: SCC22 
                 22115 
                 AL096839 
                   Streptomyces coelicolor  cosmid C22. 
                 
                   Streptomyces coelicolor 
                 
                 37,071 
                 12-Jul-99 
               
               
                 rxa02532 
                 1170 
                 GB_OV: AF137219 
                 831 
                 AF137219 
                   Amia calva  mixed lineage leukemia-like protein (MII) gene, partial cds. 
                 
                   Amia calva 
                 
                 36,853 
                 7-Sep-99 
               
               
                   
                   
                 GB_EST30: AI645057 
                 301 
                 AI645057 
                 vs52a10.y1 Stratagene mouse Tcell 937311  Mus musculus  cDNA clone 
                 
                   Mus musculus 
                 
                 41,860 
                 29-Apr-99 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 1149882 5′, mRNA sequence. 
               
               
                   
                   
                 GB_EST20: AA822595 
                 429 
                 AA822595 
                 vs52a10.r1 Stratagene mouse Tcell 937311  Mus musculus  cDNA clone 
                 
                   Mus musculus 
                 
                 42,353 
                 17-Feb-98 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 1149882 5′, mRNA sequence. 
               
               
                 rxa02536 
                 879 
                 GB_HTG2: AF130866 
                 118874 
                 AF130866 
                   Homo sapiens  chromosome 8 clone PAC 172N13 map 8q24, *** 
                 
                   Homo sapiens 
                 
                 40,754 
                 21-MAR-1999 
               
               
                   
                   
                   
                   
                   
                 SEQUENCING IN PROGRESS ***, in unordered pieces. 
               
               
                   
                   
                 GB_HTG2: AF130866 
                 118874 
                 AF130866 
                   Homo sapiens  chromosome 8 clone PAC 172N13 map 8q24, *** 
                 
                   Homo sapiens 
                 
                 40,754 
                 21-MAR-1999 
               
               
                   
                   
                   
                   
                   
                 SEQUENCING IN PROGRESS ***, in unordered pieces. 
               
               
                   
                   
                 GB_PL1: ATT12J5 
                 84499 
                 AL035522 
                   Arabidopsis thaliana  DNA chromosome 4, BAC clone T12J5 (ESSAII project). 
                 
                   Arabidopsis thaliana 
                 
                 35,063 
                 24-Feb-99 
               
               
                 rxa02550 
                 1434 
                 GB_BA1: MTCY279 
                 9150 
                 Z97991 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 17/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 37,773 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MSGB1970CS 
                 39399 
                 L78815 
                   Mycobacterium leprae  cosmid B1970 DNA sequence. 
                 
                   Mycobacterium leprae 
                 
                 39,024 
                 15-Jun-96 
               
               
                   
                   
                 GB_BA2: SC2H4 
                 25970 
                 AL031514 
                   Streptomyces coelicolor  cosmid 2H4. 
                   Streptomyces coelicolor  A3(2) 
                 37,906 
                 19-OCT-1999 
               
               
                 rxa02559 
                 1026 
                 GB_BA1: MTV004 
                 69350 
                 AL009198 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 144/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 47,358 
                 18-Jun-98 
               
               
                   
                   
                 GB_PAT: I28684 
                 5100 
                 I28684 
                 Sequence 1 from patent U.S. Pat. No. 5573915. 
                 Unknown. 
                 39,138 
                 6-Feb-97 
               
               
                   
                   
                 GB_BA1: MTU27357 
                 5100 
                 U27357 
                   Mycobacterium tuberculosis  cyclopropane mycolic acid synthase (cma1) gene, 
                 
                   Mycobacterium tuberculosis 
                 
                 39,138 
                 26-Sep-95 
               
               
                   
                   
                   
                   
                   
                 complete cds. 
               
               
                 rxa02622 
                 1683 
                 GB_BA2: AE001780 
                 11997 
                 AE001780 
                   Thermotoga maritima  section 92 of 136 of the complete genome. 
                 
                   Thermotoga maritima 
                 
                 44,914 
                 2-Jun-99 
               
               
                   
                   
                 GB_OV: AF064564 
                 49254 
                 AF064564 
                   Fugu rubripes  neurofibromatosis type 1 (NF1), A-kinase anchor protein 
                 
                   Fugu rubripes 
                 
                 39,732 
                 17-Aug-99 
               
               
                   
                   
                   
                   
                   
                 (AKAP84), BAW protein (BAW), and WSB1 protein (WSB1) genes, complete 
               
               
                   
                   
                   
                   
                   
                 cds. 
               
               
                   
                   
                 GB_OV: AF064564 
                 49254 
                 AF064564 
                   Fugu rubripes  neurofibromatosis type 1 (NF1), A-kinase anchor protein 
                 
                   Fugu rubripes 
                 
                 36,703 
                 17-Aug-99 
               
               
                   
                   
                   
                   
                   
                 (AKAP84), BAW protein (BAW), and WSB1 protein (WSB1) genes, complete 
               
               
                   
                   
                   
                   
                   
                 cds. 
               
               
                 rxa02623 
                 714 
                 GB_GSS5: AQ818728 
                 444 
                 AQ818728 
                 HS_5268_A1_G09_SP6E RPCI-11 Human Male BAC Library  Homo sapiens   
                 
                   Homo sapiens 
                 
                 38,801 
                 26-Aug-99 
               
               
                   
                   
                   
                   
                   
                 genomic clone Plate = 844 Col = 17 Row = M, genomic survey sequence. 
               
               
                   
                   
                 GB_HTG5: AC011083 
                 198586 
                 AC011083 
                   Homo sapiens  chromosome 9 clone RP11-111M7 map 9, WORKING DRAFT 
                 
                   Homo sapiens 
                 
                 35,714 
                 19-Nov-99 
               
               
                   
                   
                   
                   
                   
                 SEQUENCE, 51 unordered pieces. 
               
               
                   
                   
                 GB_GSS6: AQ826948 
                 544 
                 AQ826948 
                 HS_5014_A2_C12_T7A RPCI-11 Human Male BAC Library  Homo sapiens   
                 
                   Homo sapiens 
                 
                 39,146 
                 27-Aug-99 
               
               
                   
                   
                   
                   
                   
                 genomic clone Plate = 590 Col = 24 Row = E, genomic survey sequence. 
               
               
                 rxa02629 
                 708 
                 GB_VI: BRSMGP 
                 462 
                 M86652 
                 Bovine respiratory syncytial virus membrane glycoprotein mRNA, complete 
                 Bovine respiratory syncytial 
                 37,013 
                 28-Apr-93 
               
               
                   
                   
                   
                   
                   
                 cds. 
                 virus 
               
               
                   
                   
                 GB_VI: BRSMGP 
                 462 
                 M86652 
                 Bovine respiratory syncytial virus membrane glycoprotein mRNA, complete 
                 Bovine respiratory syncytial 
                 37,013 
                 28-Apr-93 
               
               
                   
                   
                   
                   
                   
                 cds. 
                 virus 
               
               
                 rxa02645 
                 1953 
                 GB_PAT: A45577 
                 1925 
                 A45577 
                 Sequence 1 from Patent WO9519442. 
                 
                   Corynebacterium glutamicum 
                 
                 39,130 
                 07-MAR-1997 
               
               
                   
                   
                 GB_PAT: A45581 
                 1925 
                 A45581 
                 Sequence 5 from Patent WO9519442. 
                 
                   Corynebacterium glutamicum 
                 
                 39,130 
                 07-MAR-1997 
               
               
                   
                   
                 GB_BA1: CORILVA 
                 1925 
                 L01508 
                   Corynebacterium glutamicum  threonine dehydratase (ilvA) gene, complete 
                 
                   Corynebacterium glutamicum 
                 
                 39,130 
                 26-Apr-93 
               
               
                   
                   
                   
                   
                   
                 cds. 
               
               
                 rxa02646 
                 1392 
                 GB_BA1: CORILVA 
                 1925 
                 L01508 
                   Corynebacterium glutamicum  threonine dehydratase (ilvA) gene, complete 
                 
                   Corynebacterium glutamicum 
                 
                 99,138 
                 26-Apr-93 
               
               
                   
                   
                   
                   
                   
                 cds. 
               
               
                   
                   
                 GB_PAT: A45585 
                 1925 
                 A45585 
                 Sequence 9 from Patent WO9519442. 
                 
                   Corynebacterium glutamicum 
                 
                 99,066 
                 07-MAR-1997 
               
               
                   
                   
                 GB_PAT: A45583 
                 1925 
                 A45583 
                 Sequence 7 from Patent WO9519442. 
                 
                   Corynebacterium glutamicum 
                 
                 99,066 
                 07-MAR-1997 
               
               
                 rxa02648 
                 1326 
                 GB_OV: ICTCNC 
                 2049 
                 M83111 
                   Ictalurus punctatus  cyclic nucleotide-gated channel RNA sequence. 
                 
                   Ictalurus punctatus 
                 
                 38,402 
                 24-MAY-1993 
               
               
                   
                   
                 GB_EST11: AA265464 
                 345 
                 AA265464 
                 mx91c06.r1 Soares mouse NML  Mus musculus  cDNA clone IMAGE: 693706 
                 
                   Mus musculus 
                 
                 38,655 
                 20-MAR-1997 
               
               
                   
                   
                   
                   
                   
                 5′, mRNA sequence. 
               
               
                   
                   
                 GB_GSS8: AQ006950 
                 480 
                 AQ006950 
                 CIT-HSP-2294E14.TR CIT-HSP  Homo sapiens  genomic clone 2294E14, 
                 
                   Homo sapiens 
                 
                 36,074 
                 27-Jun-98 
               
               
                   
                   
                   
                   
                   
                 genomic survey sequence. 
               
               
                 rxa02653 
               
               
                 rxa02687 
                 1068 
                 GB_BA1: CORPHEA 
                 1088 
                 M13774 
                   C. glutamicum  pheA gene encoding prephenate dehydratase, complete cds. 
                 
                   Corynebacterium glutamicum 
                 
                 99,715 
                 26-Apr-93 
               
               
                   
                   
                 GB_PAT: E04483 
                 948 
                 E04483 
                 DNA encoding prephenate dehydratase. 
                 
                   Corynebacterium glutamicum 
                 
                 98,523 
                 29-Sep-97 
               
               
                   
                   
                 GB_PAT: E06110 
                 948 
                 E06110 
                 DNA encoding prephenate dehydratase. 
                 
                   Corynebacterium glutamicum 
                 
                 98,523 
                 29-Sep-97 
               
               
                 rxa02717 
                 1005 
                 GB_PL1: HVCH4H 
                 59748 
                 Y14573 
                   Hordeum vulgare  DNA for chromosome 4H. 
                 
                   Hordeum vulgare 
                 
                 36,593 
                 25-MAR-1999 
               
               
                   
                   
                 GB_PR2: HS310H5 
                 29718 
                 Z69705 
                 Human DNA sequence from cosmid 310H5 from a contig from the tip of the 
                 
                   Homo sapiens 
                 
                 36,089 
                 22-Nov-99 
               
               
                   
                   
                   
                   
                   
                 short arm of chromosome 16, spanning 2 Mb of 16p13.3. Contains EST and 
               
               
                   
                   
                   
                   
                   
                 CpG island. 
               
               
                   
                   
                 GB_PR3: AC004754 
                 39188 
                 AC004754 
                   Homo sapiens  chromosome 16, cosmid clone RT286 (LANL), complete 
                 
                   Homo sapiens 
                 
                 36,089 
                 28-MAY-1998 
               
               
                   
                   
                   
                   
                   
                 sequence. 
               
               
                 rxa02754 
                 1461 
                 GB_HTG2: AC008223 
                 130212 
                 AC008223 
                   Drosophila melanogaster  chromosome 3 clone BACR16I18 (D815) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 32,757 
                 2-Aug-99 
               
               
                   
                   
                   
                   
                   
                 16.I.18 map 95A-95A strain y; cn bw sp, 
               
               
                   
                   
                   
                   
                   
                 *** SEQUENCING IN PROGRESS***, 101 unordered pieces. 
               
               
                   
                   
                 GB_HTG2: AC008223 
                 130212 
                 AC008223 
                   Drosophila melanogaster  chromosome 3 clone BACR16I18 (D815) RPCI-98 
                 
                   Drosophila melanogaster 
                 
                 32,757 
                 2-Aug-99 
               
               
                   
                   
                   
                   
                   
                 16.I.18 map 95A-95A strain y; cn bw sp, *** SEQUENCING IN PROGRESS 
               
               
                   
                   
                   
                   
                   
                 ***, 101 unordered pieces. 
               
               
                   
                   
                 GB_BA1: MTCY71 
                 42729 
                 Z92771 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 141/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 37,838 
                 10-Feb-99 
               
               
                 rxa02758 
                 1422 
                 GB_HTG5: AC011678 
                 171967 
                 AC011678 
                   Homo sapiens  clone 14_B_7, *** SEQUENCING IN PROGRESS ***, 20 
                 
                   Homo sapiens 
                 
                 35,331 
                 5-Nov-99 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                   
                   
                 GB_HTG5: AC011678 
                 171967 
                 AC011678 
                   Homo sapiens  clone 14_B_7, *** SEQUENCING IN PROGRESS ***, 20 
                 
                   Homo sapiens 
                 
                 33,807 
                 5-Nov-99 
               
               
                   
                   
                   
                   
                   
                 unordered pieces. 
               
               
                   
                   
                 GB_BA2: AF064070 
                 23183 
                 AF064070 
                   Burkholderia pseudomallei  putative dihydroorotase (pyrC) gene, partial cds; 
                 
                   Burkholderia pseudomallei 
                 
                 36,929 
                 20-Jan-99 
               
               
                   
                   
                   
                   
                   
                 putative 1-acyl-sn-glycerol-3-phosphate acyltransferase (plsC), putative 
               
               
                   
                   
                   
                   
                   
                 diadenosine tetraphosphatase (apaH), complete cds; type II O-antigen 
               
               
                   
                   
                   
                   
                   
                 biosynthesis gene cluster, complete sequence; putative undecaprenyl 
               
               
                   
                   
                   
                   
                   
                 phosphate N-acetylglucosaminyltransferase, and putative UDP-glucose 4- 
               
               
                   
                   
                   
                   
                   
                 epimerase genes, complete cds; and putative galactosyl transferase gene, 
               
               
                   
                   
                   
                   
                   
                 partial cds. 
               
               
                 rxa02771 
                 678 
                 GB_BA2: AF038651 
                 4077 
                 AF038651 
                   Corynebacterium glutamicum  dipeptide-binding protein (dciAE) gene, partial 
                 
                   Corynebacterium glutamicum 
                 
                 99,852 
                 14-Sep-98 
               
               
                   
                   
                   
                   
                   
                 cds; adenine phosphoribosyltransferase (apt) and GTP pyrophosphokinase 
               
               
                   
                   
                   
                   
                   
                 (rel) genes, complete cds; and unknown gene. 
               
               
                   
                   
                 GB_IN1: CELT19B4 
                 37121 
                 U80438 
                   Caenorhabditis elegans  cosmid T19B4. 
                 
                   Caenorhabditis elegans 
                 
                 43,836 
                 04-DEC-1996 
               
               
                   
                   
                 GB_EST36: AV193572 
                 360 
                 AV193572 
                 AV193572 Yuji Kohara unpublished cDNA: Strain N2 hermaphrodite embryo 
                 
                   Caenorhabditis elegans 
                 
                 48,588 
                 22-Jul-99 
               
               
                   
                   
                   
                   
                   
                   Caenorhabditis elegans  cDNA clone yk618h8 5′, mRNA sequence. 
               
               
                 rxa02772 
                 1158 
                 GB_BA2: AF038651 
                 4077 
                 AF038651 
                   Corynebacterium glutamicum  dipeptide-binding protein (dciAE) gene, partial 
                 
                   Corynebacterium glutamicum 
                 
                 99,914 
                 14-Sep-98 
               
               
                   
                   
                   
                   
                   
                 cds; adenine phosphoribosyltransferase (apt) and GTP pyrophosphokinase 
               
               
                   
                   
                   
                   
                   
                 (rel) genes, complete cds; and unknown gene. 
               
               
                   
                   
                 GB_BA1: MTCY227 
                 35946 
                 Z77724 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 114/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 38,339 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: U00011 
                 40429 
                 U00011 
                   Mycobacterium leprae  cosmid B1177. 
                 
                   Mycobacterium leprae 
                 
                 38,996 
                 01-MAR-1994 
               
               
                 rxa02790 
                 1266 
                 GB_BA1: MTCY159 
                 33818 
                 Z83863 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 111/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 37,640 
                 17-Jun-98 
               
               
                   
                   
                 GB_PR4: AC006581 
                 172931 
                 AC006581 
                   Homo sapiens  12p21 BAC RPCI11-259O18 (Roswell Park Cancer Institute 
                 
                   Homo sapiens 
                 
                 37,906 
                 3-Jun-99 
               
               
                   
                   
                   
                   
                   
                 Human BAC Library) complete sequence. 
               
               
                   
                   
                 GB_PR4: AC006581 
                 172931 
                 AC006581 
                   Homo sapiens  12p21 BAC RPCI11-259O18 (Roswell Park Cancer Institute 
                 
                   Homo sapiens 
                 
                 35,280 
                 3-Jun-99 
               
               
                   
                   
                   
                   
                   
                 Human BAC Library) complete sequence. 
               
               
                 rxa02791 
                 951 
                 GB_BA1: MTCY159 
                 33818 
                 Z83863 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 111/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 39,765 
                 17-Jun-98 
               
               
                   
                   
                 GB_OV: CHKCEK2 
                 3694 
                 M35195 
                 Chicken tyrosine kinase (cek2) mRNA, complete cds. 
                 
                   Gallus gallus 
                 
                 38,937 
                 28-Apr-93 
               
               
                   
                   
                 GB_BA1: MSASDASK 
                 5037 
                 Z17372 
                   M. smegmatis  asd, ask-alpha, and ask-beta genes. 
                 
                   Mycobacterium smegmatis 
                 
                 38,495 
                 9-Aug-94 
               
               
                 rxa02802 
                 1194 
                 GB_EST24: AI223401 
                 169 
                 AI223401 
                 qg48g01.x1 Soares_testis_NHT  Homo sapiens  cDNA clone IMAGE: 1838448 
                 
                   Homo sapiens 
                 
                 40,828 
                 27-OCT-1998 
               
               
                   
                   
                   
                   
                   
                 3′ similar to WP: C25D7.8 CE08394;, mRNA sequence. 
               
               
                   
                   
                 GB_EST24: AI223401 
                 169 
                 AI223401 
                 qg48g01.x1 Soares_testis_NHT  Homo sapiens  cDNA clone IMAGE: 1838448 
                 
                   Homo sapiens 
                 
                 40,828 
                 27-OCT-1998 
               
               
                   
                   
                   
                   
                   
                 3′ similar to WP: C25D7.8 CE08394;, mRNA sequence. 
               
               
                 rxa02814 
                 494 
                 GB_BA1: MTCY7D11 
                 22070 
                 Z95120 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 138/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 58,418 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MTCY7D11 
                 22070 
                 Z95120 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 138/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 40,496 
                 17-Jun-98 
               
               
                   
                   
                 GB_PR1: HSAJ2962 
                 778 
                 AJ002962 
                   Homo sapiens  mRNA for hB-FABP. 
                 
                   Homo sapiens 
                 
                 39,826 
                 8-Jan-98 
               
               
                 rxa02843 
                 608 
                 GB_BA1: CGAJ4934 
                 1160 
                 AJ004934 
                   Corynebacterium glutamicum  dapD gene, complete CDS. 
                 
                   Corynebacterium glutamicum 
                 
                 100,000 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MTCI364 
                 29540 
                 Z93777 
                   Mycobacterium tuberculosis  H37Rv complete genome; segment 52/162. 
                 
                   Mycobacterium tuberculosis 
                 
                 37,710 
                 17-Jun-98 
               
               
                   
                   
                 GB_BA1: MLU15180 
                 38675 
                 U15180 
                   Mycobacterium leprae  cosmid B1756. 
                 
                   Mycobacterium leprae 
                 
                 39,626 
                 09-MAR-1995 
               
               
                 rxs03205 
                 963 
                 GB_BA1: BLSIGBGN 
                 2906 
                 Z49824 
                   B. lactofermentum  orf1 gene and sigB gene. 
                 
                   Corynebacterium glutamicum 
                 
                 98,854 
                 25-Apr-96 
               
               
                   
                   
                 GB_EST21: AA980237 
                 377 
                 AA980237 
                 ua32a12.r1 Soares_mammary_gland_NbMMG  Mus musculus  cDNA clone 
                 
                   Mus musculus 
                 
                 41,489 
                 27-MAY-1998 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 1348414 5′ similar to TR: Q61025 Q61025 HYPOTHETICAL 15.2 KD 
               
               
                   
                   
                   
                   
                   
                 PROTEIN.;, mRNA sequence. 
               
               
                   
                   
                 GB_EST23: AI158316 
                 371 
                 AI158316 
                 ud27c05.r1 Soares_thymus_2NbMT  Mus musculus  cDNA clone 
                 
                   Mus musculus 
                 
                 38,005 
                 30-Sep-98 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 1447112 5′, mRNA sequence. 
               
               
                 rxs03223 
                 1237 
                 GB_IN1: LMFL2743 
                 38368 
                 AL031910 
                   Leishmania major  Friedlin chromosome 4 cosmid L2743. 
                 
                   Leishmania major 
                 
                 39,869 
                 15-DEC-1999 
               
               
                   
                   
                 GB_PR3: HSDJ61B2 
                 119666 
                 AL096710 
                 Human DNA sequence from clone RP1-61B2 on chromosome 6p11.2-12.3 
                 
                   Homo sapiens 
                 
                 34,930 
                 17-DEC-1999 
               
               
                   
                   
                   
                   
                   
                 Contains isoforms 1 and 3 of BPAG1 (bullous pemphigoid antigen 1 
               
               
                   
                   
                   
                   
                   
                 (230/240 kD), an exon of a gene similar to murine MACF cytoskeletal protein, 
               
               
                   
                   
                   
                   
                   
                 STSs and GSSs, complete sequence. 
               
               
                   
                   
                 GB_PR3: HSDJ61B2 
                 119666 
                 AL096710 
                 Human DNA sequence from clone RP1-61B2 on chromosome 6p11.2-12.3 
                 
                   Homo sapiens 
                 
                 34,634 
                 17-DEC-1999 
               
               
                   
                   
                   
                   
                   
                 Contains isoforms 1 and 3 of BPAG1 (bullous pemphigoid antigen 1 
               
               
                   
                   
                   
                   
                   
                 (230/240 kD), an exon of a gene similar to murine MACF cytoskeletal protein, 
               
               
                   
                   
                   
                   
                   
                 STSs and GSSs, complete sequence.