Patent Publication Number: US-2009227538-A1

Title: N-(Hetero)Aryl Indole Derivatives as Pesticides

Description:
The present invention relates to new N-aryl indole compounds of formula 
     
       
         
         
             
             
         
       
     
     wherein 
     R 1  signifies hydrogen, halogen, cyano, nitro, C 1 -C 6 -alkyl which is unsubstituted or substituted by halogen, cyano, hydroxyl, C 1 -C 4 -alkoxy, C 1 -C 4 -alkylthio, amino, N-mono- or N,N-di-C 1 -C 4 -alkylamino, N-benzylamino or N-pyridylmethylamino, C 3 -C 6 -cycloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 3 -C 6 -cycloalkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, hydroxy, C 1 -C 6 -alkoxy, C 2 -C 6 -alkenyloxy, C 2 -C 6 -alkynyloxy, C 3 -C 6 -cycloalkyloxy, halo-C 1 -C 6 -alkoxy, halo-C 2 -C 6 -alkenyloxy, halo-C 2 -C 6 -alkynyloxy, halo-C 3 -C 6 -cycloalkyloxy, SH, C 1 -C 6 -alkylthio, C 3 -C 6 -cycloalkylthio, halo-C 1 -C 6 -alkylthio, halo-C 3 -C 6 -cycloalkylthio, C 1 -C 6 -alkylsulfinyl, C 3 -C 6 -cycloalkylsulfinyl, halo-C 1 -C 6 -alkylsulfinyl, halo-C 3 -C 6 -cycloalkylsulfinyl, C 1 -C 6 -alkylsulfonyl, C 3 -C 6 -cycloalkylsulfonyl, halo-C 1 -C 6 -alkylsulfonyl, halo-C 3 -C 6 -cycloalkylsulfonyl, SO 3 R 7  SO 2 NR 7 R 8 , NR 7 R 8 , NHCOR 7 , NHCOOR 7 , COR 7 , COOR 7 , CONR 7 R 8 , C 1 -C 4 -alkyl-silyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted aryloxy, unsubstituted or substituted arylalkyloxy, unsubstituted or substituted arylthio, unsubstituted or substituted arylalkylthio, unsubstituted or substituted heteroaryl, unsubstituted or substituted heteroaryloxy, or unsubstituted or substituted heteroarylalkyl, the aryl, arylalkyl, aryloxy, arylalkyloxy, arylthio, arylalkylthio, heteroaryl, heteroaryloxy and heteroarylalkyl substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, hydroxy, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, NH 2 , C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 -alkylthio, COR 7 , COOR 7  and CONR 7 R 8 ; 
     R 2  signifies halogen, cyano, nitro, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, hydroxyl-C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, halo-C 3 -C 6 -cycloalkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, hydroxy, C 1 -C 6 -alkoxy, C 2 -C 6 -alkenyloxy, C 2 -C 6 -alkynyloxy, C 3 -C 6 -cycloalkyloxy, halo-C 1 -C 6 -alkoxy, halo-C 2 -C 6 -alkenyloxy, halo-C 2 -C 6 -alkynyloxy, halo-C 3 -C 6 -cycloalkyloxy, SH, C 1 -C 6 -alkylthio, C 3 -C 6 -cycloalkylthio, halo-C 1 -C 6 -alkylthio, halo-C 3 -C 6 -cycloalkylthio, C 1 -C 6 -alkylsulfinyl, C 3 -C 6 -cycloalkylsulfinyl, halo-C 1 -C 6 -alkylsulfinyl, halo-C 3 -C 6 -cycloalkylsulfinyl, C 1 -C 6 -alkylsulfonyl, C 3 -C 6 -cycloalkylsulfonyl, halo-C 1 -C 6 -alkylsulfonyl, halo-C 3 -C 6 -cycloalkylsulfonyl, SO 3 R 7 , SO 2 NR 7 R 8 , NR 7 R 8 , COR 7 , COOR 7 , CONR 7 R 8 , unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted aryloxy, unsubstituted or substituted arylalkyloxy, unsubstituted or substituted arylthio, unsubstituted or substituted heteroaryl, unsubstituted or substituted heteroarylalkyl, unsubstituted or substituted heteroaryloxy, or unsubstituted or substituted heteroarylthio, the aryl, arylalkyl, aryloxy, arylalkyloxy, arylthio, heteroaryl, heteroarylalkyl, heteroaryloxy and heteroarylthio substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, hydroxy, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, NH 2 , C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 -alkylthio, COR 7 , COOR 7  and CONR 7 R 8 , whereby, if m is greater than 1, the signification of R 2  may be identical or different, or two radicals R 2  together with the ring atoms, to which they are attached, form an aliphatic ring of 5 to 6 atoms, optionally including one or two additional heteroatoms selected from the group consisting of nitrogen, sulfur or oxygen, or one carbonyl group, optionally substituted with 1 to 4 substituents, independently from each other selected form the group consisting of halogen, CN, NO 2 , hydroxy, C 1 -C 6 -alkyl, and C 1 -C 6 -alkoxy; 
     R 3  signifies hydrogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 6 -cycloalkylmethyl, C 1 -C 4 -alkoxy-methyl, C 1 -C 2 -alkoxy-C 1 -C 2 -alkoxymethyl, phenoxymethyl which is unsubstituted or substituted in the phenyl moiety by halogen, C 1 -C 2 -alkyl, halo-C 1 -C 2 -alkyl or C 1 -C 2 -alkoxy, benzyloxymethyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 3 -C 6 -cycloalkyl, halo-C 1 -C 6 -cycloalkylmethyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, COR 7 , COOR 7 , CONR 7 R 8 , CSNR 7 R 8 , C 1 -C 4 -alkyl-silyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted heteroaryl, or unsubstituted or substituted heteroarylalkyl, the aryl, arylalkyl, heteroaryl and heteroarylalkyl substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, hydroxy, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, NH 2 , C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 -alkylthio, COR 7 , COOR 7  and CONR 7 R 8 ; 
     R 4  signifies C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, halo-C 3 -C 8 -cycloalkyl, hydroxy-C 1 -C 6 -alkyl, COR 7 , COOR 7 , piperonyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted heteroaryl, or unsubstituted or substituted heteroarylalkyl, the aryl, arylalkyl, heteroaryl and heteroarylalkyl substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, hydroxy, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, NH 2 , C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 -alkylthio, COR 7 , COOR 7  and CONR 7 R 8 ; 
     R 5  signifies hydrogen, C 1 -C 8 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, phenyl-C 2 -C 6 -alkynyl, C 3 -C 6 -cycloalkyl-C 2 -C 6 -alkynyl, C 1 -C 4 -alkylthiomethyl, hydroxymethyl, C 1 -C 4 -alkoxymethyl, aminomethyl wherein the N-atom is unsubstituted or mono- or disubstituted by C 1 -C 4 -alkyl, C 1 -C 2 -alkoxy-C 1 -C 4 -alkyl, benzyl, unsubstituted or halogen-, halo-C 1 -C 2 -alkyl- or halo-C 1 -C 2 -alkoxy-substituted phenyl or unsubstituted or halogen-, halo-C 1 -C 2 -alkyl- or halo-C 1 -C 2 -alkoxy-substituted pyridylmethyl, C 3 -C 8 -cycloalkyl, halo-C 3 -C 8 -cycloalkyl, C 5 -C 6 -cycloalkylmethyl wherein 1 to 3 carbon atoms of the cycloalkyl may be replaced by a heteroatom selected from the group consisting of NH, N(C 1 -C 4 -alkyl), O and S, cyano, COR 7 , COOR 7 , piperonyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted heteroaryl, or unsubstituted or substituted heteroarylalkyl, the aryl, arylalkyl, heteroaryl and heteroarylalkyl substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, hydroxy, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, NH 2 , C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 -alkylthio, halo C 1 -C 6 -alkylthio, COR 7 , COOR 7  and CONR 7 R 8 ; 
     or R 4  and R 5  together with the carbon atoms to which they are attached, form an aliphatic ring of 3 to 6 atoms, optionally including one additional heteroatom selected from the group consisting of nitrogen, sulfur or oxygen, or one carbonyl group, optionally substituted with 1 to 4 substituents, independently from each other selected form the group consisting of halogen, CN, NO 2 , hydroxy, C 1 -C 6 -alkyl, and C 1 -C 6 -alkoxy; 
     R 6  signifies, halogen, cyano, nitro, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 3 -C 6 -cycloalkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, hydroxy, C 1 -C 6 -alkoxy, C 2 -C 6 -alkenyloxy, C 2 -C 6 -alkynyloxy, C 3 -C 6 -cycloalkyloxy, halo-C 1 -C 6 -alkoxy, halo-C 2 -C 6 -alkenyloxy, halo-C 2 -C 6 -alkynyloxy, halo-C 3 -C 6 -cycloalkyloxy, SH, C 1 -C 6 -alkylthio, C 3 -C 6 -cycloalkylthio, halo-C 1 -C 6 -alkylthio, halo-C 3 -C 6 -cycloalkylthio, C 1 -C 6 -alkylsulfinyl, C 3 -C 6 -cycloalkylsulfinyl, halo-C 1 -C 6 -alkylsulfinyl, halo-C 3 -C 6 -cycloalkylsulfinyl, C 1 -C 6 -alkylsulfonyl, C 3 -C 6 -cycloalkylsulfonyl, halo-C 1 -C 6 -alkylsulfonyl, halo-C 3 -C 6 -cycloalkylsulfonyl, SO 3 R 7  SO 2 NR 7 R 8 , NR 7 R 8 , COR 7 , COOR 7 , CONR 7 R 8 , SF 5 , unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted aryloxy, unsubstituted or substituted arylthio, unsubstituted or substituted heteroaryl, unsubstituted or substituted heteroarylalkyl, unsubstituted or substituted heteroaryloxy, or unsubstituted or substituted heteroarylthio, the aryl, arylalkyl, aryloxy, arylthio, heteroaryl, heteroarylalkyl, heteroaryloxy and heteroarylthio substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, hydroxy, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, NH 2 , C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 -alkylthio, COR 7 , COOR 7  and CONR 7 R 8 , whereby the signification of R 6  may be identical or different for all significations of n; 
     R 7  and R 8  are independently from each other hydrogen, unsubstituted or substituted C 1 -C 6 -alkyl, unsubstituted or substituted C 1 -C 2 -alkoxyC 1 -C 2 -alkyl, unsubstituted or substituted C 2 -C 6 -alkenyl, unsubstituted or substituted C 2 -C 6 -alkynyl, unsubstituted or substituted C 3 -C 6 -cycloalkyl, the substituents in each case independently from each other being selected from the group consisting of halogen, cyano, NO 2 , C 1 -C 6 -alkoxy, alkylcarbonyl, alkylcarbonyloxy and alkoxycarbonyl; unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted heteroaryl or unsubstituted or substituted heteroarylalkyl, the aryl, arylalkyl, heteroaryl and heteroarylalkyl substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, hydroxy, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, NH 2 , C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 -alkylthio, COR 7 , COOR 7  and CONR 7 R 8 ; 
     A signifies O, S, SO or SO 2 ; 
     X is C or N; 
     m signifies 0, 1, 2, 3 or 4; and 
     n signifies 1, 2, 3, 4 or 5; 
     with the proviso that n is greater than 1 if X is C; 
     their manufacture and use in the control of ectoparasites, especially ticks and fleas, on warm-blooded productive livestock and domestic animals and plants, and furthermore pesticides containing at least one of these compounds. 
     Substituted N-aryl indole compounds are known to show pharmaceutical activity as, e.g., sodium channel inhibitors, dopamine receptor antagonists, antidepressiva or anti-inflammatory agents. Surprisingly, it has now been found that certain derivatives of this compound class have excellent pesticidal properties, especially against ecto-parasites on productive livestock and domestic animals and plants. 
     The general terms used hereinbefore and hereinafter have the following meanings, unless defined otherwise. 
     Alkyl—as a group per se and as structural element of other groups and compounds, for example halogenalkyl, alkoxy, and alkylthio—is, in each case with due consideration of the specific number of carbon atoms in the group or compound in question, either straight-chained, i.e. methyl, ethyl, propyl, butyl, pentyl or hexyl, or branched, e.g. isopropyl, isobutyl, sec.-butyl, tert.-butyl, isopentyl, neopentyl or isohexyl, preferably straight-chained or branched C 1 -C 4 -alkyl and in particular C 1 -C 2 -alkyl. 
     Alkenyl—as a group per se and as structural element of other groups and compounds—is, in each case with due consideration of the specific number of carbon atoms in the group or compound in question and of the conjugated or isolated double bonds—either straight-chained, e.g. allyl, 2-butenyl, 3-pentenyl, 1-hexenyl or 1,3-hexadienyl, or branched, e.g. isopropenyl, isobutenyl, isoprenyl, tert.-pentenyl or isohexenyl. 
     Alkynyl—as a group per se and as structural element of other groups and compounds—is, in each case with due consideration of the specific number of carbon atoms in the group or compound in question and of the conjugated or isolated double bonds—either straight-chained, e.g. propargyl, 2-butinyl, 3-pentinyl, 1-hexinyl, 1-heptinyl or 3-hexen-1-inyl, or branched, e.g. 3-methylbut-1-inyl, 4-ethylpent-1-inyl or 4-methylhex-2-inyl. 
     Cycloalkyl—as a group per se and as structural element of other groups and compounds such as cycloalkylmethyl,—is, in each case with due consideration of the specific number of carbon atoms in the group or compound in question, cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl, in particular cyclopentyl or cyclohexyl. 
     Examples of C 5 -C 6 -cycloalkyl wherein carbon atoms are replaced by heteroatoms are morpholinyl, piperidinyl, piperazinyl, N-methyl- or N-ethylpiperazinyl, tetrahydrofuranyl or dioxolanyl, in particular morpholinyl and, N-methyl- or N-ethylpiperazinyl. 
     Halogen—as a group per se and as structural element of other groups and compounds such as haloalkyl, haloalkoxy and haloalkylthio—is fluorine, chlorine, bromine or iodine, especially fluorine, chlorine or bromine, in particular fluorine or chlorine. 
     Halogen-substituted carbon-containing groups and compounds, such as haloalkyl, haloalkoxy or haloalkylthio, may be partially halogenated or perhalogenated, whereby in the case of multiple halogenation, the halogen substituents may be identical or different. Examples of halogen-alkyl—as a group per se and as structural element of other groups and compounds such as halogen-alkoxy or halogen-alkylthio,—are methyl which is mono- to trisubstituted by fluorine, chlorine and/or bromine, such as CHF 2  or CF 3 ; ethyl which is mono- to pentasubstituted by fluorine, chlorine and/or bromine, such as CH 2 CF 3 , CF 2 CF 3 , CF 2 CCl 3 , CF 2 CHCl 2 , CF 2 CHF 2 , CF 2 CFCl 2 , CF 2 CHBr 2 , CF 2 CHClF, CF 2 CHBrF or CClFCHClF; propyl or isopropyl, mono- to heptasubstituted by fluorine, chlorine and/or bromine, such as CH 2 CHBrCH 2 Br, CF 2 CHFCF 3 , CH 2 CF 2 CF 3  or CH(CF 3 ) 2 ; butyl or one of its isomers, mono- to nonasubstituted by fluorine, chlorine and/or bromine, such as CF(CF 3 )CHFCF 3  or CH 2 (CF 2 ) 2 CF 3 ; pentyl or one of its isomers substituted once to eleven times by fluorine, chlorine and/or bromine, such as CF(CF 3 )(CHF) 2 CF 3  or CH 2 (CF 2 ) 3 CF 3 ; and hexyl or one of its isomers substituted once to thirteen times by fluorine, chlorine and/or bromine, such as (CH 2 ) 4 —CHBrCH 2 Br, CF 2 (CHF) 4 CF 3 , CH 2 (CF 2 ) 4 CF 3  or C(CF 3 ) 2 (CHF) 2 CF 3 . 
     Aryl—as a group per se and as structural element of other groups and compounds such as arylalkyl, aryloxy and arylamino—is, for example, phenyl which may be unsubstituted or one to fivefold substituted or naphthyl which may be unsubstituted or one to sevenfold substituted, in particular unsubstituted or substituted phenyl. 
     Heteroaryl as a group per se and as structural element of other groups and compounds such as heteroarylalkyl, heteroaryloxy and heteroarylarylamino are groups like but not limited to pyridyl, pyrimidyl, s-triazinyl, 1,2,4-triazinyl, thienyl, furanyl, pyrryl, pyrazolyl, imidazolyl, thiazolyl, triazolyl, oxazolyl, thiadiazolyl, oxadiazolyl, benzothienyl, benzofuranyl, benzothiazolyl, indolyl or indazolyl, preferably pyridyl, pyrimidyl, pyrryl, imidazolyl or furanyl, in particular pyridyl or pyrimidyl. 
     Arylalkyl is considered as a combination of the terms alkyl and aryl, for example benzyl. 
     Heteroarylalkyl is considered as a combination of the terms alkyl and heteroaryl. 
     Alkoxy groups preferably have a chain length of 1 to 6 carbon atoms, more preferably from 1 to 4 carbon atoms and in particular 1 or 2 carbon atoms. Alkoxy is for example methoxy, ethoxy, propoxy, isopropoxy, n-butoxy, isobutoxy, sec.-butoxy and tert.-butoxy, as well as the isomers pentyloxy and hexyloxy; preferably methoxy and ethoxy. Haloalkoxy groups preferably have a chain length of 1 to 6 carbon atoms. Haloalkoxy is e.g. fluoromethoxy, difluoromethoxy, trifluoromethoxy, 2,2,2-trifluoroethoxy, 1,1,2,2-tetrafluoroethoxy, 2-fluoroethoxy, 2-chloroethoxy, 2,2-difluoroethoxy and 2,2,2-trichloroethoxy; preferably difluoromethoxy, 2-chloroethoxy and trifluoromethoxy. 
     Alkylthio groups preferably have a chain length of 1 to 6 carbon atoms. Alkylthio is for example methylthio, ethylthio, propylthio, isopropylthio, n-butylthio, isobutylthio, sec.-butylthio or tert.-butylthio, preferably methylthio and ethylthio. 
     Preferred embodiments within the scope of the invention are: 
     1. A compound of formula I, wherein 
     R 1  signifies hydrogen, halogen, cyano, nitro, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 3 -C 6 -cycloalkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, hydroxy, C 1 -C 6 -alkoxy, C 2 -C 6 -alkenyloxy, C 2 -C 6 -alkynyloxy, C 3 -C 6 -cycloalkyloxy, halo-C 1 -C 6 -alkoxy, halo-C 2 -C 6 -alkenyloxy, halo-C 2 -C 6 -alkynyloxy, halo-C 3 -C 6 -cycloalkyloxy, SH, C 1 -C 6 -alkylthio, C 3 -C 6 -cycloalkylthio, halo-C 1 -C 6 -alkylthio, halo-C 3 -C 6 -cycloalkylthio, C 1 -C 6 -alkylsulfinyl, C 3 -C 6 -cycloalkylsulfinyl, halo-C 1 -C 6 -alkylsulfinyl, halo-C 3 -C 6 -cycloalkylsulfinyl, C 1 -C 6 -alkylsulfonyl, C 3 -C 6 -cycloalkylsulfonyl, halo-C 1 -C 6 -alkylsulfonyl, halo-C 3 -C 6 -cycloalkylsulfonyl, SO 3 R 7 , SO 2 NR 7 R 8 , NR 7 R 8 , NHCOR 7 , NHCOOR 7 , COR 7 , COOR 7 , CONR 7 R 8 , unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted aryloxy, unsubstituted or substituted arylalkyloxy, unsubstituted or substituted arylthio, unsubstituted or substituted arylalkylthio, unsubstituted or substituted heteroaryl, unsubstituted or substituted heteroaryloxy, or unsubstituted or substituted heteroarylalkyl, the substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, hydroxy, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, NH 2 , C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 -alkylthio, COR 7 , COOR 7  and CONR 7 R 8 ; 
     R 2  signifies halogen, cyano, nitro, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 3 -C 6 -cycloalkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, hydroxy, C 1 -C 6 -alkoxy, C 2 -C 6 -alkenyloxy, C 2 -C 6 -alkynyloxy, C 3 -C 6 -cycloalkyloxy, halo-C 1 -C 6 -alkoxy, halo-C 2 -C 6 -alkenyloxy, halo-C 2 -C 6 -alkynyloxy, halo-C 3 -C 6 -cycloalkyloxy, SH, C 1 -C 6 -alkylthio, C 3 -C 6 -cycloalkylthio, halo-C 1 -C 6 -alkylthio, halo-C 3 -C 6 -cycloalkylthio, C 1 -C 6 -alkylsulfinyl, C 3 -C 6 -cycloalkylsulfinyl, halo-C 1 -C 6 -alkylsulfinyl, halo-C 3 -C 6 -cycloalkylsulfinyl, C 1 -C 6 -alkylsulfonyl, C 3 -C 6 -cycloalkylsulfonyl, halo-C 1 -C 6 -alkylsulfonyl, halo-C 3 -C 6 -cycloalkylsulfonyl, SO 3 R 7  SO 2 NR 7 R 8 , NR 7 R 8 , COR 7 , COOR 7 , CONR 7 R 8 , unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted aryloxy, unsubstituted or substituted arylalkyloxy, unsubstituted or substituted arylthio, unsubstituted or substituted heteroaryl, unsubstituted or substituted heteroarylalkyl, unsubstituted or substituted heteroaryloxy, or unsubstituted or substituted heteroarylthio, the substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, hydroxy, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, NH 2 , C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 -alkylthio, COR 7 , COOR 7  and CONR 7 R 8 , whereby, if m is greater than 1, the signification of R 2  may be identical or different; 
     R 3  signifies hydrogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 1 -C 6 -cycloalkylmethyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 3 -C 6 -cycloalkyl, halo-C 1 -C 6 -cycloalkylmethyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, COR 7 , COOR 7 , CONR 7 R 8 , CSNR 7 R 8 , unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted heteroaryl, or unsubstituted or substituted heteroarylalkyl, the substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, hydroxy, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, NH 2 , C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 -alkylthio, COR 7 , COOR 7  and CONR 7 R 8 ; 
     R 4  signifies C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, halo-C 3 -C 8 -cycloalkyl, hydroxy-C 1 -C 6 -alkyl, COR 7 , COOR 7 , piperonyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted heteroaryl, or unsubstituted or substituted heteroarylalkyl, the substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, hydroxy, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, NH 2 , C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 -alkylthio, COR 7 , COOR 7  and CONR 7 R 8 ; 
     R 5  signifies hydrogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, halo-C 3 -C 8 -cycloalkyl, COR 7 , COOR 7 , piperonyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted heteroaryl, or unsubstituted or substituted heteroarylalkyl, the substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, hydroxy, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, NH 2 , C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 -alkylthio, COR 7 , COOR 7  and CONR 7 R 8 ; 
     R 6  signifies halogen, cyano, nitro, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 3 -C 6 -cycloalkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, hydroxy, C 1 -C 6 -alkoxy, C 2 -C 6 -alkenyloxy, C 2 -C 6 -alkynyloxy, C 3 -C 6 -cycloalkyloxy, halo-C 1 -C 6 -alkoxy, halo-C 2 -C 6 -alkenyloxy, halo-C 2 -C 6 -alkynyloxy, halo-C 3 -C 6 -cycloalkyloxy, SH, C 1 -C 6 -alkylthio, C 3 -C 6 -cycloalkylthio, halo-C 1 -C 6 -alkylthio, halo-C 3 -C 6 -cycloalkylthio, C 1 -C 6 -alkylsulfinyl, C 3 -C 6 -cycloalkylsulfinyl, halo-C 1 -C 6 -alkylsulfinyl, halo-C 3 -C 6 -cycloalkylsulfinyl, C 1 -C 6 -alkylsulfonyl, C 3 -C 6 -cycloalkylsulfonyl, halo-C 1 -C 6 -alkylsulfonyl, halo-C 3 -C 6 -cycloalkylsulfonyl, SO 3 R 7 , SO 2 NR 7 R 8 , NR 7 R 8 , COR 7 , COOR 7 , CONR 7 R 8 , SF 5 , unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted aryloxy, unsubstituted or substituted arylthio, unsubstituted or substituted heteroaryl, unsubstituted or substituted heteroarylalkyl, unsubstituted or substituted heteroaryloxy, or unsubstituted or substituted heteroarylthio, the substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, hydroxy, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, NH 2 , C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 -alkylthio, COR 7 , COOR 7  and CONR 7 R 8 , whereby the signification of R 6  may be identical or different for all significations of n; 
     R 7  and R 8  are independently from each other hydrogen, unsubstituted or substituted C 1 -C 6 -alkyl, unsubstituted or substituted C 2 -C 6 -alkenyl, unsubstituted or substituted C 2 -C 6 -alkynyl, unsubstituted or substituted C 3 -C 6 -cycloalkyl, the substituents in each case independently from each other being selected from the group consisting of halogen, cyano, NO 2 , C 1 -C 6 -alkoxy, alkylcarbonyl, alkylcarbonyloxy and alkoxycarbonyl; unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl, unsubstituted or substituted heteroaryl or unsubstituted or substituted heteroarylalkyl, the substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, hydroxy, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, NH 2 , C 1 -C 6 -alkylamino, di-C 1 -C 6 -alkylamino, C 1 -C 6 -alkylthio, COR 7 , COOR 7  and CONR 7 R 8 ; 
     A signifies O, S, SO or SO 2 ; 
     X signifies C or N; 
     m signifies 0, 1, 2, 3 or 4; and 
     n signifies 1, 2, 3, 4 or 5; 
     with the proviso that n is greater than 1 if X is C; 
     2. A compound of formula I, wherein R 1  signifies hydrogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, C 1 -C 6 -alkylcarbonyl, halo-C 1 -C 6 -alkylcarbonyl, C 1 -C 6 -alkoxycarbonyl, halo-C 1 -C 6 -alkoxycarbonyl, NR 7 R 8 , unsubstituted or substituted phenyl, unsubstituted or substituted phenylthio or unsubstituted or substituted naphthyl, the substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, halo-C 1 -C 6 -alkylthio, C 1 -C 6 -alkylsulfinyl, halo-C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -alkylsulfonyl and halo-C 1 -C 6 -alkylsulfonyl; 
     preferably hydrogen, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxycarbonyl, halo-C 1 -C 6 -alkoxycarbonyl, unsubstituted or substituted phenyl, unsubstituted or substituted phenylthio or unsubstituted or substituted naphthyl, the substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy and halo-C 1 -C 6 -alkoxy; 
     more preferably hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxycarbonyl, unsubstituted or substituted phenyl, unsubstituted or substituted phenylthio or unsubstituted or substituted naphthyl, the substituents being selected from the group consisting of halogen, C 1 -C 4 -alkyl and halo-C 1 -C 4 -alkyl; 
     most preferably hydrogen, C 1 -C 2 -alkyl, C 1 -C 2 -alkoxycarbonyl, unsubstituted or halogen-substituted phenyl, unsubstituted phenylthio or unsubstituted naphthyl. 
     A further preferred meaning of R 1 , in addition to the meanings and preferences given above, concerns C 1 -C 6 -alkyl which is substituted, for example, by halogen, cyano, hydroxyl, C 1 -C 4 -alkoxy, C 1 -C 4 -alkylthio, amino, N-mono- or N,N-di-C 1 -C 4 -alkylamino, N-benzylamino or N-pyridylmethylamino. 
     Accordingly, a further group of particularly preferred radicals R 1  comprises hydrogen, C 1 -C 4 -alkyl which is unsubstituted or substituted by halogen, cyano, hydroxyl, C 1 -C 2 -alkoxy, C 1 -C 2 -alkylthio, N-mono- or N,N-di-C 1 -C 2 -alkylamino or N-pyridylmethylamino-, C 2 -C 4 -alkenyl, C 2 -C 4 -alkynyl, C 1 -C 4 -alkylcarbonyl, C 1 -C 4 -alkoxycarbonyl, phenyl and phenylthio which are each unsubstituted or substituted by halogen nitro, cyano, C 1 -C 4 -alkyl, halo-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy or halo-C 1 -C 4 -alkoxy, and naphthyl; even more preferred radicals R 1  are hydrogen, C 1 -C 2 -alkyl which is unsubstituted or substituted by hydroxyl or C 1 -C 2 -alkoxy, C 1 -C 2 -alkoxycarbonyl, phenyl which is unsubstituted or substituted by halogen, phenylthio and naphthyl, in particular hydrogen. 
     3. A compound of formula I, wherein R 2  signifies halogen, nitro, cyano, C 1 -C 6 -alkyl, C 1 -C 4 -hydroxyalkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, hydroxy, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxycarbonyl, halo-C 1 -C 6 -alkoxycarbonyl, NR 7 R 8  or unsubstituted or substituted aryl, unsubstituted or substituted aryloxy, unsubstituted or substituted benzyloxy, the substituents being selected from the group consisting of halogen, nitro, cyano, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, halo-C 1 -C 6 -alkylthio, C 1 -C 6 -alkylsulfinyl, halo-C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -alkylsulfonyl and halo-C 1 -C 6 -alkylsulfonyl, whereby, if m is greater than 1, the signification of R 2  may be identical or different; 
     preferably halogen, nitro, cyano, C 1 -C 4 -alkyl, halo-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, halo-C 1 -C 4 -alkoxy, C 1 -C 4 -alkoxycarbonyl or unsubstituted or substituted phenyl, unsubstituted or substituted phenyloxy, unsubstituted or substituted benzyloxy, the substituents being selected from the group consisting of halogen, nitro, cyano, C 1 -C 4 -alkyl, halo-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy and halo-C 1 -C 4 -alkoxy, whereby, if m is greater than 1, the signification of R 2  may be identical or different; 
     more preferably halogen, nitro, C 1 -C 2 -alkyl, halo-C 1 -C 2 -alkyl, C 1 -C 2 -alkoxy, halo-C 1 -C 4 -alkoxy, C 1 -C 2 -alkoxycarbonyl or unsubstituted or substituted benzyloxy, the substituents being selected from the group consisting of halogen, C 1 -C 2 -alkyl and C 1 -C 2 -alkoxy, whereby, if m is greater than 1, the signification of R 2  may be identical or different; most preferably halogen, nitro, C 1 -C 2 -alkyl, C 1 -C 2 -alkoxy, C 1 -C 2 -alkoxycarbonyl or benzyloxy; in particular halogen, nitro, methyl, methoxy, methoxycarbonyl or benzyloxy, especially halogen such as chlorine or in particular fluorine. 
     In case that two radicals R 2  together with the ring atoms, to which they are attached, form a ring of 5 to 6 atoms, this is preferably a five- or six-membered cycloalkyl ring comprising one or two same or different hetero atoms selected from the group consisting of O and N and being unsubstituted or substituted by C 1 -C 4 -alkyl, in particular a dioxolan ring. 
     A further group of particularly preferred radicals R 2  comprises halogen, cyano, nitro, C 1 -C 2 -alkyl, halo-C 1 -C 2 -alkyl, hydroxy-C 1 -C 4 -alkyl, hydroxy, C 1 -C 2 -alkoxy, benzyloxy, amino, N-mono- or N,N-di C 1 -C 2 -alkylamino and C 1 -C 2 -alkoxycarbonyl, or two radicals R 2 , together with the carbon atoms to which they are attached, form a dioxolan ring. 
     4. A compound of formula I, wherein R 3  signifies hydrogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkylmethyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, C 1 -C 6 -alkoxycarbonyl, halo-C 1 -C 6 -alkoxycarbonyl, C 2 -C 6 -alkenyloxycarbonyl, halo-C 2 -C 6 -alkenyloxycarbonyl, C 2 -C 6 -alkynyloxycarbonyl, halo-C 2 -C 6 -alkynyloxycarbonyl, thiophenylcarbonyl, piperonylcarbonyl, C 1 -C 6 -alkylaminocarbonyl, di(C 1 -C 6 -alkyl)aminocarbonyl, C 1 -C 6 -alkylaminothiocarbonyl, di(C 1 -C 6 -alkyl)aminothiocarbonyl, unsubstituted or substituted C 1 -C 6 -alkylcarbonyl, the substituents being selected from the group consisting of C 1 -C 6 -alkoxycarbonyl, halo-C 1 -C 6 -alkoxycarbonyl, C 1 -C 6 -alkylcarbonyloxy, halo-C 1 -C 6 -alkylcarbonyloxy and phenyl; unsubstituted or substituted benzyl, unsubstituted or substituted benzoyl, unsubstituted or substituted benzyloxycarbonyl or unsubstituted or substituted phenylaminocarbonyl, the substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, halo-C 1 -C 6 -alkylthio, C 1 -C 6 -alkylsulfinyl, halo-C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -alkylsulfonyl and halo-C 1 -C 6 -alkylsulfonyl; 
     preferably hydrogen, C 1 -C 6 -alkyl, C 3 -C 6 -cycloalkylmethyl, C 2 -C 6 -alkenyl, C 1 -C 6 -alkoxycarbonyl, halo-C 1 -C 6 -alkoxycarbonyl, C 2 -C 6 -alkenyloxycarbonyl, halo-C 2 -C 6 -alkenyloxycarbonyl, C 2 -C 6 -alkynyloxycarbonyl, halo-C 2 -C 6 -alkynyloxycarbonyl, thiophenylcarbonyl, piperonylcarbonyl, C 1 -C 6 -alkylaminocarbonyl, di(C 1 -C 6 -alkyl)aminocarbonyl, C 1 -C 6 -alkylaminothiocarbonyl, di(C 1 -C 6 -alkyl)aminothiocarbonyl, unsubstituted or substituted C 1 -C 6 -alkylcarbonyl, the substituents being selected from the group consisting of C 1 -C 6 -alkoxycarbonyl, C 1 -C 6 -alkylcarbonyloxy and phenyl; unsubstituted or substituted benzyl, unsubstituted or substituted benzoyl, unsubstituted or substituted benzyloxycarbonyl or unsubstituted or substituted phenylaminocarbonyl, the substituents in each case independently from each other being selected from the group consisting of halogen, cyano, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy and halo-C 1 -C 6 -alkoxy; 
     more preferably hydrogen, C 1 -C 4 -alkyl, C 3 -C 4 -cycloalkylmethyl, C 2 -C 4 -alkenyl, C 1 -C 4 -alkoxycarbonyl, halo-C 1 -C 4 -alkoxycarbonyl, C 2 -C 4 -alkenyloxycarbonyl, halo-C 2 -C 4 -alkenyloxycarbonyl, C 2 -C 4 -alkynyloxycarbonyl, halo-C 2 -C 4 -alkynyloxycarbonyl, thiophenylcarbonyl, piperonylcarbonyl, C 1 -C 4 -alkylaminocarbonyl, di(C 1 -C 4 -alkyl)aminocarbonyl, C 1 -C 4 -alkylaminothiocarbonyl, di(C 1 -C 4 -alkyl)aminothiocarbonyl, unsubstituted or substituted C 1 -C 4 -alkylcarbonyl, the substituents being selected from the group consisting of C 1 -C 4 -alkoxycarbonyl, C 1 -C 4 -alkylcarbonyloxy and phenyl; unsubstituted or substituted benzyl, unsubstituted or substituted benzoyl, unsubstituted or substituted benzyloxycarbonyl or unsubstituted or substituted phenylaminocarbonyl, the substituents in each case being selected from the group consisting of halogen, cyano, C 1 -C 4 -alkyl, halo-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy and halo-C 1 -C 4 -alkoxy; 
     most preferably hydrogen, C 1 -C 2 -alkyl, C 3 -cycloalkylmethyl, C 2 -C 3 -alkenyl, C 1 -C 2 -alkoxycarbonyl, halo-C 1 -C 2 -alkoxycarbonyl, C 2 -C 3 -alkenyloxycarbonyl, halo-C 2 -C 3 -alkenyloxycarbonyl, C 2 -C 3 -alkynyloxycarbonyl, halo-C 2 -C 3 -alkynyloxycarbonyl, thiophenylcarbonyl, piperonylcarbonyl, C 1 -C 2 -alkylaminocarbonyl, di(C 1 -C 2 -alkyl)aminocarbonyl, C 1 -C 2 -alkylaminothiocarbonyl, di(C 1 -C 2 -alkyl)aminothiocarbonyl, C 1 -C 2 -alkylcarbonyl, benzyl, benzoyl, benzyloxycarbonyl or phenylaminocarbonyl; 
     in particular hydrogen, methyl, cyclopropylmethyl, 2-propenyl, methoxycarbonyl, 2-propenyloxycarbonyl, halo-vinyloxycarbonyl, propargyloxycarbonyl, thiophenylcarbonyl, piperonylcarbonyl, C 1 -C 2 -alkylaminocarbonyl, C 1 -C 2 -alkylaminothiocarbonyl, methylcarbonyl, benzyl, benzoyl, benzyloxycarbonyl or phenylaminocarbonyl. 
     Further preferred meanings of R 3 , in addition to the meanings and preferences given above, concern C 1 -C 4 -alkoxymethyl, C 1 -C 2 -alkoxy-C 1 -C 2 -alkoxymethyl, phenoxymethyl which is unsubstituted or substituted in the phenyl moiety by halogen, C 1 -C 2 -alkyl, halo-C 1 -C 2 -alkyl or C 1 -C 2 -alkoxy, benzyloxymethyl, and a radical COR 7 , wherein R 7  is C 1 -C 2 -alkoxyC 1 -C 2 -alkyl being unsubstituted or substituted by carboxy or COO—C 1 -C 2 -alkyl. Especially preferred meanings of R 3  within this group are C 1 -C 2 -alkoxymethyl, C 1 -C 2 -alkoxy-C 1 -C 2 -alkoxymethyl, phenoxymethyl which is unsubstituted or substituted in the phenyl moiety by halogen, benzyloxymethyl and carboxymethoxymethylcarbonyl. 
     A further group of particularly preferred radicals R 3  therefore comprises hydrogen; C 1 -C 4 -alkyl; C 3 -C 4 -cycloalkylmethyl; C 1 -C 2 -alkoxymethyl; C 1 -C 2 -alkoxy-C 1 -C 2 -alkoxymethyl; benzyl which is unsubstituted or substituted by halogen, halo-C 1 -C 2 -alkyl or cyano; phenoxymethyl and benzyloxymethyl which are each unsubstituted or substituted in the phenyl moiety by halogen; carboxymethoxymethylcarbonyl; a radical COR 7 , wherein R 7  is C 1 -C 6 -alkyl, acetyloxy-C 1 -C 4 -alkyl, C 5 -C 6 -cycloalkyl, phenyl which is unsubstituted or substituted by halogen, halo-C 1 -C 2 -alkyl or cyano, phenylethyl, thienyl or piperonyl; a radical CONHR 7  wherein R 7  is C 1 -C 6 -alkyl, phenyl which is unsubstituted or substituted by halogen, halo-C 1 -C 2 -alkyl, C 1 -C 2 -alkoxy, halo-C 1 -C 2 -alkoxy, amino or N-mono- or N,N-di-C 1 -C 2 -amino; a radical C(O)OR 7  wherein R 7  is C 1 -C 6 -alkyl, benzyl, C 2 -C 4 -alkenyl which is unsubstituted or substituted by halogen, or is C 2 -C 4 -alkynyl; and a radical C(S)NHR 7  wherein R 7  is C 1 -C 6 -alkyl, or phenyl which is unsubstituted or substituted by halogen, halo-C 1 -C 2 -alkyl or C 1 -C 2 -alkyl, in particular hydrogen. 
     5. A compound of formula I, wherein R 4  signifies unsubstituted or substituted C 1 -C 6 -alkyl, COOR 7  or halo-C 1 -C 6 -alkyl; the substituents being selected from the group consisting of halogen, cyano, hydroxyl, C 1 -C 4 -alkoxy and halo-C 1 -C 4 -alkoxy; 
     preferably unsubstituted or substituted C 1 -C 4 -alkyl or halo-C 1 -C 4 -alkyl; the substituents being selected from the group consisting of halogen, cyano, hydroxyl, C 1 -C 4 -alkoxy; more preferably C 1 -C 3 -alkyl or halo-C 1 -C 2 -alkyl; more preferably C 1 -C 2 -alkyl or halo-C 1 -C 2 -alkyl; 
     most preferably methyl or halomethyl; in particular methyl or trifluoromethyl; 
     6. A compound of formula I, wherein R 5  signifies hydrogen, C 1 -C 8 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, piperonyl, COOR 7 , unsubstituted or substituted phenyl or unsubstituted or substituted benzyl, the substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, halo-C 1 -C 6 -alkylthio, C 1 -C 6 -alkylsulfinyl, halo-C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -alkylsulfonyl and halo-C 1 -C 6 -alkylsulfonyl; 
     preferably hydrogen, C 1 -C 4 -alkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -alkynyl, halo-C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, piperonyl, unsubstituted or substituted phenyl or unsubstituted or substituted benzyl, the substituents in each case independently from each other being selected from the group consisting of halogen, C 1 -C 4 -alkyl, halo-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy and halo-C 1 -C 4 -alkoxy; 
     more preferably C 1 -C 2 -alkyl, halo-C 1 -C 2 -alkyl, ethenyl, ethynyl, phenyl or benzyl; 
     most preferably methyl, halomethyl, phenyl or benzyl; 
     in particular methyl or trifluoromethyl. 
     Further preferred meanings of R 5 , in addition to the meanings and preferences given above, concern C 1 -C 4 -alkylthiomethyl; hydroxymethyl; C 1 -C 4 -alkoxymethyl; aminomethyl wherein the N-atom is unsubstituted or mono- or disubstituted by C 1 -C 4 -alkyl, C 1 -C 2 -alkoxy-C 1 -C 4 -alkyl, benzyl, unsubstituted or halogen-, halo-C 1 -C 2 -alkyl- or halo-C 1 -C 2 -alkoxy-substituted phenyl or unsubstituted or halogen-, halo-C 1 -C 2 -alkyl- or halo-C 1 -C 2 -alkoxy-substituted pyridylmethyl; C 5 -C 6 -cycloalkylmethyl wherein 1 to 3 carbon atoms of the cycloalkyl may be replaced by a heteroatom selected from the group consisting of NH, N(C 1 -C 4 -alkyl), O and S; phenyl-C 2 -C 6 -alkynyl, in particular phenylethynyl; C 3 -C 6 -cycloalkyl-C 2 -C 6 -alkynyl, in particular cyclopropylethynyl; and cyano. 
     A further group of particularly preferred radicals R 5  therefore comprises hydrogen; C 1 -C 8 -alkyl; halo-C 1 -C 2 -alkyl; hydroxymethyl; benzyl; C 5 -C 6 -cycloalkyl; C 2 -C 6 -alkenyl; C 2 -C 4 -alkynyl; phenyl-C 2 -C 4 -alkynyl; C 3 -C 6 -cycloalkyl-C 2 -C 4 -alkynyl; C 1 -C 2 -alkylthiomethyl; C 1 -C 2 -alkoxymethyl; aminomethyl wherein the N-atom is unsubstituted or mono- or disubstituted by C 1 -C 2 -alkyl, C 1 -C 2 -alkoxy-C 1 -C 2 -alkyl, benzyl, unsubstituted or halogen-, halo-C 1 -C 2 -alkyl- or halo-C 1 -C 2 -alkoxy-substituted phenyl or unsubstituted or halogen-substituted pyridylmethyl; N—C 1 -C 2 -piperazinylmethyl; morpholinylmethyl; N-imidazolmethyl; piperonyl; phenyl which is unsubstituted or substituted by halogen, halo-C 1 -C 2 -alkyl, halo-C 1 -C 2 -alkoxy or halo-C 1 -C 2 -alkylthio; cyano; and a radical COOR 7  wherein R 7  is hydrogen or C 1 -C 2 -alkyl. Most preferred meanings of R 5  are C 1 -C 8 -alkyl, halo-C 1 -C 2 -alkyl, C 2 -C 6 -alkenyl, or C 2 -C 4 -alkynyl; in particular methyl, trifluoromethyl, ethenyl or ethynyl. 
     In case that R 4  and R 5  together with the carbon atoms to which they are attached, form a ring, this ring is, for example a piperidinyl or N—C 1 -C 2 -piperidinyl ring. 
     7. A compound of formula I, wherein R 6  signifies halogen, nitro, cyano, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, halo-C 1 -C 6 -alkylthio, C 1 -C 6 -alkylsulfinyl, halo-C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -alkylsulfonyl or halo-C 1 -C 6 -alkylsulfonyl, SF 5 , whereby the signification of R 6  may be identical or different for all significations of n; 
     preferably halogen, nitro, cyano, C 1 -C 4 -alkyl, halo-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, halo-C 1 -C 4 -alkoxy, C 1 -C 4 -alkylthio or halo-C 1 -C 4 -alkylthio, SF 5 , whereby the signification of R 6  may be identical or different for all significations of n; 
     more preferably halogen, cyano, C 1 -C 2 -alkyl, halo-C 1 -C 2 -alkyl, C 1 -C 2 -alkoxy or halo-C 1 -C 2 -alkoxy, SF 5 , whereby the signification of R 6  may be identical or different for all significations of n; 
     most preferably halogen, methyl, halomethyl, methoxy or halomethoxy, SF 5 , whereby the signification of R 6  may be identical or different for all significations of n; 
     in particular halogen or trifluoromethyl, whereby the signification of R 6  may be identical or different for all significations of n. 
     A further group of particularly preferred radicals R 6  comprises C 1 -C 2 -alkyl, phenyl, halo-C 1 -C 2 -alkyl, halo-C 1 -C 2 -alkoxy, halogen, cyano, nitro, CHO, C(O)—C 1 -C 2 -alkyl, C(O)O—C 1 -C 2 -alkyl, N-mono- and N,N-di-C 1 -C 2 -alkylamino, SF 5  and sulfo (SO 3 H). Most preferred meanings of Re are chlorine, fluorine, trifluoromethyl or cyano, in particular chlorine and trifluoromethyl. 
     8. A compound of formula I, wherein A signifies O or S; 
     preferably O; 
     9. A compound of formula I, wherein X signifies C; 
     preferably halogen-substituted C; 
     10. A compound of formula I, wherein m signifies 0, 1, 2, 3 or 4; 
     preferably 0, 1 or 2; 
     more preferably 0 or 1; 
     11. A compound of formula I, wherein n signifies 1, 2, 3 or 4; 
     preferably 1, 2 or 3; with the proviso that n is greater than 1 if X is C; 
     more preferably 2 or 3; 
     most preferably 3. 
     12. A compound of formula I, wherein 
     R 1  signifies hydrogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, C 1 -C 6 -alkylcarbonyl, halo-C 1 -C 6 -alkylcarbonyl, C 1 -C 6 -alkoxycarbonyl, halo-C 1 -C 6 -alkoxycarbonyl, NR 7 R 8 , unsubstituted or substituted phenyl, unsubstituted or substituted phenylthio or unsubstituted or substituted naphthyl, the substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, halo-C 1 -C 6 -alkylthio, C 1 -C 6 -alkylsulfinyl, halo-C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -alkylsulfonyl and halo-C 1 -C 6 -alkylsulfonyl; 
     R 2  signifies halogen, nitro, cyano, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, hydroxy, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkoxycarbonyl, halo-C 1 -C 6 -alkoxycarbonyl, NR 7 R 8  or unsubstituted or substituted aryl, unsubstituted or substituted aryloxy, unsubstituted or substituted benzyloxy, the substituents being selected from the group consisting of halogen, nitro, cyano, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, halo-C 1 -C 6 -alkylthio, C 1 -C 6 -alkylsulfinyl, halo-C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -alkylsulfonyl and halo-C 1 -C 6 -alkylsulfonyl, whereby, if m is greater than 1, the signification of R 2  may be identical or different; 
     R 3  signifies hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -cycloalkylmethyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, C 1 -C 6 -alkoxycarbonyl, halo-C 1 -C 6 -alkoxycarbonyl, C 2 -C 6 -alkenyloxycarbonyl, halo-C 2 -C 6 -alkenyloxycarbonyl, C 2 -C 6 -alkynyloxycarbonyl, halo-C 2 -C 6 -alkynyloxycarbonyl, thiophenylcarbonyl, piperonylcarbonyl, C 1 -C 6 -alkylaminocarbonyl, di(C 1 -C 6 -alkyl)aminocarbonyl, C 1 -C 6 -alkylaminothiocarbonyl, di(C 1 -C 6 -alkyl)aminothiocarbonyl, unsubstituted or substituted C 1 -C 6 -alkylcarbonyl, the substituents being selected from the group consisting of C 1 -C 6 -alkoxycarbonyl, halo-C 1 -C 6 -alkoxycarbonyl, C 1 -C 6 -alkylcarbonyloxy, halo-C 1 -C 6 -alkylcarbonyloxy and phenyl; unsubstituted or substituted benzyl, unsubstituted or substituted benzoyl, unsubstituted or substituted benzyloxycarbonyl or unsubstituted or substituted phenylaminocarbonyl, the substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, halo-C 1 -C 6 -alkylthio, C 1 -C 6 -alkylsulfinyl, halo-C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -alkylsulfonyl and halo-C 1 -C 6 -alkylsulfonyl; 
     R 4  signifies unsubstituted or substituted C 1 -C 6 -alkyl, COOR 7  or halo-C 1 -C 6 -alkyl; the substituents being selected from the group consisting of halogen, cyano, hydroxyl, C 1 -C 4 -alkoxy and halo-C 1 -C 4 -alkoxy; 
     R 5  signifies hydrogen, C 1 -C 6 -alkyl, C 2 -C 6 -alkenyl, C 2 -C 6 -alkynyl, halo-C 1 -C 6 -alkyl, halo-C 2 -C 6 -alkenyl, halo-C 2 -C 6 -alkynyl, C 3 -C 8 -cycloalkyl, piperonyl, COOR 7 , unsubstituted or substituted phenyl or unsubstituted or substituted benzyl, the substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, halo-C 1 -C 6 -alkylthio, C 1 -C 6 -alkylsulfinyl, halo-C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -alkylsulfonyl and halo-C 1 -C 6 -alkylsulfonyl; 
     R 6  signifies halogen, nitro, cyano, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy, halo-C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, halo-C 1 -C 6 -alkylthio, C 1 -C 6 -alkylsulfinyl, halo-C 1 -C 6 -alkylsulfinyl, C 1 -C 6 -alkylsulfonyl or halo-C 1 -C 6 -alkylsulfonyl, SF 5 , whereby the signification of R6 may be identical or different for all significations of n; 
     A signifies O or S; 
     X signifies C; 
     m signifies 0, 1, 2, 3 or 4; and 
     n signifies 1, 2, 3 or 4; with the proviso that n is greater than 1 if X is C; 
     13. A compound of formula I, wherein 
     R 1  signifies hydrogen, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxycarbonyl, halo-C 1 -C 6 -alkoxycarbonyl, unsubstituted or substituted phenyl, unsubstituted or substituted phenylthio or unsubstituted or substituted naphthyl, the substituents in each case independently from each other being selected from the group consisting of halogen, nitro, cyano, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy and halo-C 1 -C 6 -alkoxy; 
     R 2  signifies halogen, nitro, cyano, C 1 -C 4 -alkyl, halo-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, halo-C 1 -C 4 -alkoxy, C 1 -C 4 -alkoxycarbonyl or unsubstituted or substituted aryl, unsubstituted or substituted aryoxy, unsubstituted or substituted benzyloxy, the substituents being selected from the group consisting of halogen, nitro, cyano, C 1 -C 4 -alkyl, halo-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy and halo-C 1 -C 4 -alkoxy, whereby, if m is greater than 1, the signification of R 2  may be identical or different; 
     R 3  signifies hydrogen, C 1 -C 6 -alkyl, C 1 -C 6 -cycloalkylmethyl, C 2 -C 6 -alkenyl, C 1 -C 6 -alkoxycarbonyl, halo-C 1 -C 6 -alkoxycarbonyl, C 2 -C 6 -alkenyloxycarbonyl, halo-C 2 -C 6 -alkenyloxycarbonyl, C 2 -C 6 -alkynyloxycarbonyl, halo-C 2 -C 6 -alkynyloxycarbonyl, thiophenylcarbonyl, piperonylcarbonyl, C 1 -C 6 -alkylaminocarbonyl, di(C 1 -C 6 -alkyl)aminocarbonyl, C 1 -C 6 -alkylaminothiocarbonyl, di(C 1 -C 6 -alkyl)aminothiocarbonyl, unsubstituted or substituted C 1 -C 6 -alkylcarbonyl, the substituents being selected from the group consisting of C 1 -C 6 -alkoxycarbonyl, C 1 -C 6 -alkylcarbonyloxy and phenyl; unsubstituted or substituted benzyl, unsubstituted or substituted benzoyl, unsubstituted or substituted benzyloxycarbonyl or unsubstituted or substituted phenylaminocarbonyl, the substituents in each case independently from each other being selected from the group consisting of halogen, cyano, C 1 -C 6 -alkyl, halo-C 1 -C 6 -alkyl, C 1 -C 6 -alkoxy and halo-C 1 -C 6 -alkoxy; 
     R 4  signifies unsubstituted or substituted C 1 -C 4 -alkyl or halo-C 1 -C 4 -alkyl; the substituents being selected from the group consisting of halogen, cyano, hydroxyl, C 1 -C 4 -alkoxy; 
     R 5  signifies hydrogen, C 1 -C 4 -alkyl, C 2 -C 4 -alkenyl, C 2 -C 4 -alkynyl, halo-C 1 -C 4 -alkyl, C 3 -C 6 -cycloalkyl, piperonyl, unsubstituted or substituted phenyl or unsubstituted or substituted benzyl, the substituents in each case independently from each other being selected from the group consisting of halogen, C 1 -C 4 -alkyl, halo-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy and halo-C 1 -C 4 -alkoxy; 
     R 6  signifies halogen, nitro, cyano, C 1 -C 4 -alkyl, halo-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, halo-C 1 -C 4 -alkoxy, C 1 -C 4 -alkylthio or halo-C 1 -C 4 -alkylthio, SF 5 , whereby the signification of R 6  may be identical or different for all significations of n; 
     A signifies O; 
     X signifies halogen-substituted C; 
     m signifies 0, 1 or 2; and 
     n signifies 1, 2 or 3; with the proviso that n is greater than 1 if X is C; 
     14. A compound of formula I, wherein 
     R 1  signifies hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -alkoxycarbonyl, unsubstituted or substituted phenyl, unsubstituted or substituted phenylthio or unsubstituted or substituted naphthyl, the substituents being selected from the group consisting of halogen, C 1 -C 4 -alkyl and halo-C 1 -C 4 -alkyl; 
     R 2  signifies halogen, nitro, C 1 -C 2 -alkyl, halo-C 1 -C 2 -alkyl, C 1 -C 2 -alkoxy, halo-C 1 -C 4 -alkoxy, C 1 -C 2 -alkoxycarbonyl or unsubstituted or substituted benzyloxy, the substituents being selected from the group consisting of halogen, C 1 -C 2 -alkyl and C 1 -C 2 -alkoxy, whereby, if m is greater than 1, the signification of R 2  may be identical or different; 
     R 3  signifies hydrogen, C 1 -C 4 -alkyl, C 1 -C 4 -cycloalkylmethyl, C 2 -C 4 -alkenyl, C 1 -C 4 -alkoxycarbonyl, halo-C 1 -C 4 -alkoxycarbonyl, C 2 -C 4 -alkenyloxycarbonyl, halo-C 2 -C 4 -alkenyloxycarbonyl, C 2 -C 4 -alkynyloxycarbonyl, halo-C 2 -C 4 -alkynyloxycarbonyl, thiophenylcarbonyl, piperonylcarbonyl, C 1 -C 4 -alkylaminocarbonyl, di(C 1 -C 4 -alkyl)aminocarbonyl, C 1 -C 4 -alkylaminothiocarbonyl, di(C 1 -C 4 -alkyl)aminothiocarbonyl, unsubstituted or substituted C 1 -C 4 -alkylcarbonyl, the substituents being selected from the group consisting of C 1 -C 4 -alkoxycarbonyl, C 1 -C 4 -alkylcarbonyloxy and phenyl; unsubstituted or substituted benzyl, unsubstituted or substituted benzoyl, unsubstituted or substituted benzyloxycarbonyl or unsubstituted or substituted phenylaminocarbonyl, the substituents in each case being selected from the group consisting of halogen, cyano, C 1 -C 4 -alkyl, halo-C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy and halo-C 1 -C 4 -alkoxy; 
     R 4  signifies C 1 -C 2 -alkyl or halo-C 1 -C 2 -alkyl; 
     R 5  signifies C 1 -C 2 -alkyl, halo-C 1 -C 2 -alkyl, ethenyl, ethynyl, phenyl or benzyl; 
     R 6  signifies halogen, cyano, C 1 -C 2 -alkyl, halo-C 1 -C 2 -alkyl, C 1 -C 2 -alkoxy or halo-C 1 -C 2 -alkoxy, SF 5 , whereby the signification of R 6  may be identical or different for all significations of n; 
     A signifies O; 
     X signifies halogen-substituted C; 
     m signifies 0 or 1; and 
     n signifies 2 or 3; 
     15. A compound of formula I, wherein 
     R 1  signifies hydrogen, C 1 -C 2 -alkyl, C 1 -C 2 -alkoxycarbonyl, unsubstituted or halogen-substituted phenyl, unsubstituted phenylthio or unsubstituted naphthyl; 
     R 2  signifies halogen, nitro, methyl, methoxy, methoxycarbonyl or benzyloxy; 
     R 3  signifies hydrogen, methyl, cyclopropylmethyl, 2-propenyl, methoxycarbonyl, 2-propenyloxycarbonyl, halo-vinyloxycarbonyl, propargyloxycarbonyl, thiophenylcarbonyl, piperonylcarbonyl, C 1 -C 2 -alkylaminocarbonyl, C 1 -C 2 -alkylaminothiocarbonyl, methylcarbonyl, benzyl, benzoyl, benzyloxycarbonyl or phenylaminocarbonyl; 
     R 4  signifies methyl or trifluoromethyl; 
     R 5  signifies methyl or trifluoromethyl; 
     R 6  signifies halogen or trifluoromethyl, whereby the signification of Rr may be identical or different for all significations of n; 
     A signifies O; 
     X signifies halogen-substituted C; 
     m signifies 0 or 1; and 
     n signifies 3. 
     16. A compound of the formula 
     
       
         
         
             
             
         
       
     
     wherein for R 1 , R 2 , R 3 , R 5  and m each the above given meanings and preferences apply, and R 6 ′ and R 6 ″ are independently halogen or cyano, for example independently fluorine, chlorine or cyano, and in particular each chlorine. An especially preferred embodiment concerns the compounds of the formula Ia above, wherein R 1  is hydrogen or C 1 -C 2 -alkyl which is unsubstituted or substituted by hydroxyl or C 1 -C 2 -alkoxy, in particular hydrogen; R 2  is halogen, in particular fluorine; m is 0 or 1, R 3  is hydrogen, C 1 -C 2 -alkoxymethyl or C 1 -C 2 -alkoxy-C 1 -C 2 -alkoxymethyl, in particular hydrogen; R 5  is methyl, ethenyl or ethynyl, in particular methyl; and R 6 ′ and R 6 ″ are each independently fluorine, chlorine or cyano, preferably one chlorine and the other one chlorine, fluorine or cyano, and in particular each chlorine. 
     Within the context of the invention, particular preference is given to the compounds of formula I listed in Tables 1 to 3, and most particularly those named in the synthesis examples. 
     A further object of the invention is the process for the preparation of the compounds of formula I, respectively in free form or in salt form, for example characterised in that a compound of formula 
     
       
         
         
             
             
         
       
     
     wherein R 1 , R 2 , R 4 , R 5 , R 6 , A, X, m and n are defined as defined above, is reacted with a compound of formula 
       R 3 -Q 1   III, 
     wherein R 3  is defined as given above and Q 1  is a leaving group, optionally in the presence of a basic catalyst. If desired, a compound of formula I obtainable according to the method or in another way, respectively in free form or in salt form, may be converted into another compound of formula I, a mixture of isomers obtainable according to the method is separated and the desired isomer isolated and/or a free compound of formula I obtainable according to the method is converted into a salt or a salt of an compound of formula I obtainable according to the method is converted into the free compound of formula I or into another salt. 
     What has been stated above for salts of compounds I also applies analogously to salts of the starting materials listed herein above and herein below. 
     The reaction partners can be reacted with one another as they are, i.e. without the addition of a solvent or diluent, e.g. in the melt. In most cases, however, the addition of an inert solvent or diluent, or a mixture thereof, is of advantage. Examples of such solvents or diluents are: aromatic, aliphatic and alicyclic hydrocarbons and halogenated hydrocarbons, such as benzene, toluene, xylene, mesitylene, tetralin, chlorobenzene, dichlorobenzene, bromobenzene, petroleum ether, hexane, cyclohexane, dichloromethane, trichloromethane, tetrachloromethane, dichloroethane, trichloroethene or tetrachloroethene; ethers, such as diethyl ether, dipropyl ether, diisopropyl ether, dibutyl ether, tert-butyl methyl ether, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol dimethylether, dimethoxydiethylether, tetrahydrofuran or dioxane; ketones such as acetone, methyl ethyl ketone or methyl isobutyl ketone; amides such as N,N-dimethylformamide, N,N-diethyl-formamide, N,N-dimethylacetamide, N-methylpyrrolidone or hexamethylphosphoric acid triamide; nitriles such as acetonitrile or propionitrile; and sulfoxides, such as dimethyl sulfoxide. 
     Preferred leaving groups Q 1  are halogens, especially chlorine, bromine and iodine. 
     Suitable bases for facilitating the reaction are e.g. alkali metal or alkaline earth metal hydroxides, hydrides, amides, alkanolates, acetates, carbonates, dialkylamides or alkylsilyl-amides; alkylamines, alkylenediamines, optionally N-alkylated, optionally unsaturated, cyclo-alkylamines, basic heterocycles, ammonium hydroxides, as well as carbocyclic amines. Those which may be mentioned by way of example are sodium hydroxide, hydride, amide, methanolate, acetate, carbonate, potassium tert.-butanolate, hydroxide, carbonate, hydride, lithium diisopropyl amide, potassium bis(trimethylsilyl)-amide, calcium hydride, triethylamine, diisopropylethylamine, triethylenediamine, cyclohexylamine, N-cyclohexyl-N,N-dimethyl-amine, N,N-diethylaniline, pyridine, 4-(N,N-dimethylamino)pyridine, quinuclidine, N-methyl-morpholine, benzyltrimethylammonium hydroxide, as well as 1,5-diazabicyclo[5.4.0]undec-5-ene (DBU). Preference is given to diisopropylethylamine and sodium hydride. 
     The reaction advantageously takes place in a temperature range of ca. 0° C. to ca. 100° C., preferably from ca. 10° C. to ca. 40° C. 
     In a preferred process, a compound of formula II is reacted at room temperature in an amide, preferably N,N-dimethylformamide, with a compound of formula III in the presence of a base. 
     A further object of the invention is the process for the preparation of the compounds of formula II, respectively in free form or in salt form, for example characterised in that a compound of formula 
     
       
         
         
             
             
         
       
     
     in which R 1 , R 2 , R 5 , R 6 , X, A, m and n are defined as for formula I, is reacted with a compound of formula 
       R 4 -Q 2   V, 
     wherein R 4  is defined as mentioned above and Q 2  is a leaving group. If desired, a compound of formula II obtainable according to the method or in another way, respectively in free form or in salt form, may be converted into another compound of formula II, a mixture of isomers obtainable according to the method is separated and the desired isomer isolated and/or a free compound of formula II obtainable according to the method is converted into a salt or a salt of an compound of formula II obtainable according to the method is converted into the free compound of formula II or into another salt. 
     The reaction partners can be reacted with one another as they are, i.e. without the addition of a solvent or diluent, e.g. in the melt. In most cases, however, the addition of an inert solvent or diluent, or a mixture thereof, is of advantage. Examples of such solvents or diluents are: aromatic, aliphatic and alicyclic hydrocarbons and halogenated hydrocarbons, such as benzene, toluene, xylene, mesitylene, tetralin, chlorobenzene, dichlorobenzene, bromobenzene, petroleum ether, hexane, cyclohexane, dichloromethane, trichloromethane, tetrachloromethane, dichloroethane, trichloroethene or tetrachloroethene; ethers, such as diethyl ether, dipropyl ether, diisopropyl ether, dibutyl ether, tert-butyl methyl ether, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol dimethylether, dimethoxydiethylether, tetrahydrofuran or dioxane; amides such as N,N-dimethylformamide, N,N-diethylformamide, N,N-dimethylacetamide, N-methylpyrrolidone or hexamethyl-phosphoric acid triamide; nitriles such as acetonitrile or propionitrile; and sulfoxides, such as dimethyl sulfoxide. 
     Preferred leaving groups Q 2  are MgBr, MgCl, Mgl or Li, especially MgBr. 
     The reaction advantageously takes place in a temperature range of ca. −20° C. to ca. 100° C., preferably from ca. 0° C. to ca. 30° C. 
     In a preferred process, a compound of formula IV is reacted at room temperature in an ether, preferably diethyl ether, with a compound of formula V. 
     A further object of the invention is the process for the preparation of the compounds of formula IV, respectively in free form or in salt form, for example characterised in that a compound of formula 
     
       
         
         
             
             
         
       
     
     in which R 1 , R 2 , R 5 , A and m are defined as for formula I, is reacted with a compound of formula 
     
       
         
         
             
             
         
       
     
     wherein R 6 , X and n are defined as for formula I and Q 3  is a leaving group, optionally in the presence of a basic catalyst. If desired, a compound of formula IV obtainable according to the method or in another way, respectively in free form or in salt form, may be converted into another compound of formula IV, a mixture of isomers obtainable according to the method is separated and the desired isomer isolated and/or a free compound of formula IV obtainable according to the method is converted into a salt or a salt of an compound of formula IV obtainable according to the method is converted into the free compound of formula IV or into another salt. 
     The compounds of formula VI and VII are each known or may be obtained according to methods known in the art. 
     The reaction partners can be reacted with one another as they are, i.e. without the addition of a solvent or diluent, e.g. in the melt. In most cases, however, the addition of an inert solvent or diluent, or a mixture thereof, is of advantage. Examples of such solvents or diluents are: aromatic, aliphatic and alicyclic hydrocarbons and halogenated hydrocarbons, such as benzene, toluene, xylene, mesitylene, tetralin, chlorobenzene, dichlorobenzene, bromobenzene, petroleum ether, hexane, cyclohexane, dichloromethane, trichloromethane, tetrachloromethane, dichloroethane, trichloroethene or tetrachloroethene; ethers, such as diethyl ether, dipropyl ether, diisopropyl ether, dibutyl ether, tert-butyl methyl ether, ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol dimethylether, dimethoxydiethylether, tetrahydrofuran or dioxane; ketones such as acetone, methyl ethyl ketone or methyl isobutyl ketone; amides such as N,N-dimethylformamide, N,N-diethyl-formamide, N,N-dimethylacetamide, N-methylpyrrolidone or hexamethylphosphoric acid triamide; nitriles such as acetonitrile or propionitrile; and sulfoxides, such as dimethyl sulfoxide. 
     Suitable bases for facilitating the reaction are e.g. alkali metal or alkaline earth metal hydroxides, hydrides, amides, alkanolates, acetates, carbonates, dialkylamides or alkylsilyl-amides; alkylamines, alkylenediamines, optionally N-alkylated, optionally unsaturated, cyclo-alkylamines, basic heterocycles, ammonium hydroxides, as well as carbocyclic amines. Those which may be mentioned by way of example are sodium hydroxide, hydride, amide, methanolate, acetate, carbonate, potassium tert.-butanolate, hydroxide, carbonate, hydride, lithium diisopropylamide, potassium bis(trimethylsilyl)-amide, calcium hydride, triethylamine, diisopropylethylamine, triethylenediamine, cyclohexylamine, N-cyclohexyl-N,N-dimethyl-amine, N,N-diethylaniline, pyridine, 4-(N,N-dimethylamino)pyridine, quinuclidine, N-methyl-morpholine, benzyltrimethylammonium hydroxide, as well as 1,5-diazabicyclo[5.4.0]undec-5-ene (DBU). 
     Preferred leaving groups Q 3  are halogens, especially fluorine and chlorine. 
     The reaction advantageously takes place in a temperature range of ca. 0° C. to ca. 150° C., preferably from ca. 50° C. to ca. 120° C. 
     In a preferred process, a compound of formula VI is reacted at 90° C. in an amide, preferably N,N-dimethylformamide, with a compound of formula VII in the presence of a base, preferably potassium carbonate. 
     An alternative process for the manufacture of the compounds of formula II is characterized in that a compound of formula 
     
       
         
         
             
             
         
       
     
     wherein R 1 , R 2 , R 6 , m and n are as defined above, is reacted with a lithium-organic compound, for example n-butyllithium, followed by reaction of the resulting lithium-organic compound with a ketone of formula 
     
       
         
         
             
             
         
       
     
     wherein A, R 4  and R 5  are as defined above. 
     The compounds of formula IVa may be obtained, for example, by bromination of a compound of formula 
     
       
         
         
             
             
         
       
     
     wherein R 1 , R 2 , R 6 , m and n are as defined above, with bromine or N-bromosuccinimide (NBS). The compounds of formula IVb may be obtained by reaction of a compound of formula 
     
       
         
         
             
             
         
       
     
     wherein R 1 , R 2  and m are as defined above, with a compound of the above-mentioned formula VII. 
     The halogenation reaction of the compound of formula IVb, the metalation step and the further reaction with the ketone are all performed in a manner known per se from textbooks of organic chemistry. In addition, the compounds of the formula VIa and VIII are known or may be obtained according to processes known in the art. 
     A further alternative process for the manufacture of the compounds of formula I is characterized in that a compound of formula 
     
       
         
         
             
             
         
       
     
     wherein A, R 1 , R 2 , R 4 , R 5  and m are as defined above, is reacted with a compound of the above-mentioned formula VII to yield a compound of the above-given formula (II) which is optionally further reacted with a compound of the above-given formula Ill. The reaction conditions for this reaction sequence are suitably chosen as described before. 
     The compounds of formula VIb may be obtained by a Friedel-Crafts type reaction of a compound of formula VIa above with a compound of the formula VIII above in an inert aprotic solvent, such as for example methylene chloride or chloroform, at room temperature or at an elevated temperature between room temperature and reflux, optionally in the presence of a suitable catalyst. 
     Still a further synthetic route towards the compounds of the formula VIb is characterized in that a compound of the above-given formula VIa is reacted with a compound of the formula 
     
       
         
         
             
             
         
       
     
     wherein A and R 5  are as described above and Q 4  is a leaving group, for example halogen, to yield a compound of the above-given formula VI, which is then further reacted with a compound of the above-given formula V. 
     The reaction of the compound of formula VIa with a compound of the formula IX is a typical Friedel Crafts acylation reaction which is performed as described in textbooks of organic chemistry, for example in an aprotic organic solvent in the presence of a suitable catalyst. The reaction of the resulting compound of the formula VI with the compound of formula V is performed under conditions as described before in the reaction between the compounds of formulae IV and V. 
     Salts of compounds I may be produced in known manner. Acid addition salts, for example, are obtainable from compounds I by treating with a suitable acid or a suitable ion exchange reagent, and salts with bases are obtainable by treating with a suitable base or a suitable ion exchange reagent. 
     Salts of compounds I can be converted into the free compounds I by the usual means, acid addition salts e.g. by treating with a suitable basic composition or with a suitable ion exchange reagent, and salts with bases e.g. by treating with a suitable acid or a suitable ion exchange reagent. 
     Salts of compounds I can be converted into other salts of compounds I in a known manner; acid addition salts can be converted for example into other acid addition salts, e.g. by treating a salt of an inorganic acid, such as a hydrochloride, with a suitable metal salt, such as a sodium, barium, or silver salt, of an acid, e.g. with silver acetate, in a suitable solvent, in which a resulting inorganic salt, e.g. silver chloride, is insoluble and thus precipitates out from the reaction mixture. 
     Depending on the method and/or reaction conditions, compounds I with salt-forming characteristics can be obtained in free form or in the form of salts. 
     Compounds I can also be obtained in the form of their hydrates and/or also can include other solvents, used for example where necessary for the crystallisation of compounds present in solid form. 
     Compounds I and II may be optionally present as optical and/or geometric isomers or as a mixture thereof. The invention relates both to the pure isomers and to all possible isomeric mixtures, and is hereinbefore and hereinafter understood as doing so, even if stereochemical details are not specifically mentioned in every case. 
     Diastereoisomeric mixtures of compounds I and II, which are obtainable by the process or in another way, may be separated in known manner, on the basis of the physical-chemical differences in their components, into the pure diastereoisomers, for example by fractional crystallisation, distillation and/or chromatography. 
     Splitting of mixtures of enantiomers, that are obtainable accordingly, into the pure isomers, may be achieved by known methods, for example by recrystallisation from an optically active solvent, by chromatography on chiral adsorbents, e.g. high-pressure liquid chromatography (HPLC) on acetyl cellulose, with the assistance of appropriate micro-organisms, by cleavage with specific immobilised enzymes, through the formation of inclusion compounds, e.g. using chiral crown ethers, whereby only one enantiomer is complexed. 
     According to the invention, apart from separation of corresponding isomer mixtures, generally known methods of diastereoselective or enantioselective synthesis can also be applied to obtain pure diastereoisomers or enantiomers, e.g. by carrying out the method of the invention using educts with correspondingly suitable stereochemistry. 
     It is advantageous to isolate or synthesise the biologically more active isomer, e.g. enantiomer, provided that the individual components have differing biological efficacy. 
     In the method of the present invention, the starting materials and intermediates used are preferably those that lead to the compounds I described at the beginning as being especially useful. 
     The invention relates especially to the method of preparation described in the example. 
     Starting materials and intermediates, which are new and are used according to the invention for the preparation of compounds I, as well as their usage and process for the preparation thereof, similarly form an object of the invention. 
     The compounds I according to the invention are notable for their broad activity spectrum and are valuable active ingredients for use in pest control, including in particular the control of endo- and ecto-parasites on animals, whilst being well-tolerated by warm-blooded animals, fish and plants. 
     In the context of the present invention, ectoparasites are understood to be in particular insects, acari (mites and ticks), and crustaceans (sea lice). These include insects of the following orders: Lepidoptera, Coleoptera, Homoptera, Hemiptera, Heteroptera, Diptera, Dictyoptera, Thysanoptera, Orthoptera, Anoplura, Siphonaptera, Mallophaga, Thysanura, Isoptera, Psocoptera and Hymenoptera. However, the ectoparasites which may be mentioned in particular are those which trouble humans or animals and carry pathogens, for example flies such as  Musca domestica, Musca vetustissima, Musca autumnalis, Fannia canicularis, Sarcophaga camaria, Lucilia cuprina, Lucilia sericata, Hypoderma bovis, Hypoderma lineatum, Chrysomyia chloropyga, Dermatobia hominis, Cochliomyia hominivorax, Gasterophilus intestinalis, Oestrus ovis , biting flies such as  Haematobia irritans irritans, Haematobia irritans exigua, Stomoxys calcitrans , horse-flies (Tabanids) with the subfamilies of Tabanidae such as  Haematopota  spp. (e.g.  Haematopota pluvialis ) and  Tabanus  spp, (e.g.  Tabanus nigrovittatus ) and Chrysopsinae such as  Chrysops  spp. (e.g.  Chrysops caecutiens ); Hippoboscids such as  Melophagus ovinus  (sheep ked); tsetse flies, such as  Glossinia  spp; other biting insects like midges, such as Ceratopogonidae (biting midges), Simulildae (Blackflies), Psychodidae (Sandflies); but also blood-sucking insects, for example mosquitoes, such as  Anopheles  spp,  Aedes  spp and  Culex  spp, fleas, such as  Ctenocephalides felis  and  Ctenocephalides canis  (cat and dog fleas),  Xenopsylla cheopis, Pulex irritans, Ceratophylilus gallinae, Dermatophilus penetrans , blood-sucking lice ( Anoplura ) such as  Linognathus  spp,  Haematopinus  spp,  Solenopotes  spp,  Pediculus humanis ; but also chewing lice ( Mallophaga ) such as  Bovicola  ( Damalinia )  ovis, Bovicola  ( Damalinia )  bovis  and other  Bovicola  spp. Ectoparasites also include members of the order Acarina, such as mites (e.g.  Chorioptes bovis, Cheyletiella  spp.,  Dermanyssus gallinae, Demodex canis, Sarcoptes scabiei, Psoroptes ovis  and  Psorergates  spp. and ticks. Known representatives of ticks are, for example,  Boophilus, Amblyomma, Anocentor, Dermacentor, Haemaphysalis, Hyalomma, Ixodes, Rhipicentor, Margaropus, Rhipicephalus, Argas, Otobius  and  Ornithodoros  and the like, which preferably infest warm-blooded animals including farm animals, such as cattle, horses, pigs, sheep and goats, poultry such as chickens, turkeys, guineafowls and geese, fur-bearing animals such as mink, foxes, chinchillas, rabbits and the like, as well as domestic animals such as cats and dogs, but also humans. 
     Compounds of the formula I can also be used against hygiene pests, especially of the orider Diptera of the families Muscidae, Sarcophagidae, Anophilidae and Culicidae; the orders Orthoptera, Dictyoptera (e.g. the family Blattidae (cockroaches), such as  Blatella germanica, Blatta orientalis, Periplaneta americana ) and Hymenoptera (e.g. the families Formicidae (ants) and Vespidae (wasps). 
     Compounds I also have sustainable efficacy on parasitic mites and insects of plants. In the case of spider mites of the order Acarina, they are effective against eggs, nymphs and adults of Tetranychidae ( Tetranychus  spp. and  Panonychus  spp.). 
     They have high activity against sucking insects of the order Homoptera, especially against pests of the families Aphididae, Delphacidae, Cicadellidae, Psyllidae, Loccidae, Diaspididae and Eriophydidae (e.g. rust mite on citrus fruits); the orders Hemiptera, Heteroptera and Thysanoptera, and on the plant-eating insects of the orders Lepidoptera, Coleoptera, Diptera and Orthoptera 
     They are similarly suitable as a soil insecticide against pests in the soil. 
     The compounds of formula I are therefore effective against all stages of development of sucking insects and eating insects on crops such as cereals, cofton, rice, maize, soya, potatoes, vegetables, fruit, tobacco, hops, citrus, avocados and other crops. 
     The compounds of formula I are also effective against plant nematodes of the species  Meloidogyne, Heterodera, Pratylenchus, Ditylenchus, Radopholus, Rizoglyphus  etc. 
     In particular, the compounds are effective against helminths, in which the endoparasitic nematodes and trematodes may be the cause of serious diseases of mammals and poultry, e.g. sheep, pigs, goats, cattle, horses, donkeys, dogs, cats, guinea-pigs and exotic birds. Typical nematodes of this indication are:  Haemonchus, Trichostrongylus, Ostertagia, Nematodirus, Cooperia, Ascaris, Bunostonum, Oesophagostonum, Charbertia, Trichuris, Strongylus, Trichonema, Dictyocaulus, Capillaria, Heterakis, Toxocara, Ascaridia, Oxyuris, Ancylostoma, Uncinaria, Toxascaris  and  Parascaris . The trematodes include  Clonorchis, Dicrocoelium, Echinostoma  and in particular, the family of Fasciolideae, especially  Fasciola hepatica . The particular advantage of the compounds of formula I is their efficacy against those parasites that are resistant towards active ingredients based on benzimidazoles. 
     Certain pests of the species  Nematodirus, Cooperia  and  Oesophagostonum  infest the intestinal tract of the host animal, while others of the species  Haemonchus  and  Ostertagia  are parasitic in the stomach and those of the species  Dictyocaulus  are parasitic in the lung tissue. Parasites of the families Filariidae and Setariidae may be found in the internal cell tissue and in the organs, e.g. the heart, the blood vessels, the lymph vessels and the subcutaneous tissue. A particularly notable parasite is the heartworm of the dog,  Dirofilaria immitis . The compounds of formula I are highly effective against these parasites. 
     Furthermore, the compounds of formula I are suitable for the control of human pathogenic parasites. Of these, typical representatives that appear in the digestive tract are those of the species  Ancylostoma, Necator, Ascaris, Strongyloides, Trichinella, Capillaria, Trichuris  and  Enterobius . The compounds of the present invention are also effective against parasites of the species  Wuchereria, Brugia, Onchocerca  and  Loa  from the family of Filariidae, which appear in the blood, in the tissue and in various organs, and also against  Dracunculus  and parasites of the species  Strongyloides  and  Trichinella , which infect the gastrointestinal tract in particular. 
     The good pesticidal activity of the compounds of formula I according to the invention corresponds to a mortality rate of at least 50-60% of the pests mentioned. In particular, the compounds of formula I are notable for the exceptionally long duration of efficacy. 
     The compounds of formula I are preferably employed in unmodified form or preferably together with the adjuvants conventionally used in the art of formulation and may therefore be processed in a known manner to give, for example, emulsifiable concentrates, directly dilutable solutions, dilute emulsions, soluble powders, granules or micro-encapsulations in polymeric substances. As with the compositions, the methods of application are selected in accordance with the intended objectives and the prevailing circumstances. 
     The formulation, i.e. the agents, preparations or compositions containing the active ingredient of formula I, or combinations of these active ingredients with other active ingredients, and optionally a solid or liquid adjuvant, are produced in a manner known per se, for example by intimately mixing and/or grinding the active ingredients with spreading compositions, for example with solvents, solid carriers, and optionally surface-active compounds (surfactants). 
     The solvents in question may be: alcohols, such as ethanol, propanol or butanol, and glycols and their ethers and esters, such as propylene glycol, dipropylene glycol ether, ethylene glycol, ethylene glycol monomethyl or -ethyl ether, ketones, such as cyclohexanone, isophorone or diacetanol alcohol, strong polar solvents, such as N-methyl-2-pyrrolidone, dimethyl sulfoxide or N,N-dimethylformamide, or water, vegetable oils, such as rape, castor, coconut, or soybean oil, and also, if appropriate, silicone oils. 
     Preferred application forms for usage on warm-blooded animals in the control of helminths include solutions, emulsions, suspensions (drenches), food additives, powders, tablets including effervescent tablets, boli, capsules, micro-capsules and pour-on formulations, whereby the physiological compatibility of the formulation excipients must be taken into consideration. 
     The binders for tablets and boli may be chemically modified polymeric natural substances that are soluble in water or in alcohol, such as starch, cellulose or protein derivatives (e.g. methyl cellulose, carboxymethyl cellulose, ethylhydroxyethyl cellulose, proteins such as zein, gelatine and the like), as well as synthetic polymers, such as polyvinyl alcohol, polyvinyl pyrrolidone etc. The tablets also contain fillers (e.g. starch, microcrystalline cellulose, sugar, lactose etc.), glidants and disintegrants. 
     If the anthelminthics are present in the form of feed concentrates, then the carriers used are e.g. performance feeds, feed grain or protein concentrates. Such feed concentrates or compositions may contain, apart from the active ingredients, also additives, vitamins, antibiotics, chemotherapeutics or other pesticides, primarily bacteriostats, fungistats, coccidiostats, or even hormone preparations, substances having anabolic action or substances which promote growth, which affect the quality of meat of animals for slaughter or which are beneficial to the organism in another way. If the compositions or the active ingredients of formula I contained therein are added directly to feed or to the drinking troughs, then the formulated feed or drink contains the active ingredients preferably in a concentration of ca. 0.0005 to 0.02% by weight (5-200 ppm). 
     The compounds of formula I according to the invention may be used alone or in combination with other biocides. They may be combined with pesticides having the same sphere of activity e.g. to increase activity, or with substances having another sphere of activity e.g. to broaden the range of activity. It can also be sensible to add so-called repellents. If the range of activity is to be extended to endoparasites, e.g. wormers, the compounds of formula I are suitably combined with substances having endoparasitic properties. Of course, they can also be used in combination with antibacterial compositions. Since the compounds of formula I are adulticides, i.e. since they are effective in particular against the adult stage of the target parasites, the addition of pesticides which instead attack the juvenile stages of the parasites may be very advantageous. In this way, the greatest part of those parasites that produce great economic damage will be covered. Moreover, this action will contribute substantially to avoiding the formation of resistance. Many combinations may also lead to synergistic effects, i.e. the total amount of active ingredient can be reduced, which is desirable from an ecological point of view. Preferred groups of combination partners and especially preferred combination partners are named in the following, whereby combinations may contain one or more of these partners in addition to a compound of formula I. 
     Suitable partners in the mixture may be biocides, e.g. the insecticides and acaricides with a varying mechanism of activity, which are named in the following and have been known to the person skilled in the art for a long time, e.g. chitin synthesis inhibitors, growth regulators; active ingredients which act as juvenile hormones; active ingredients which act as adulticides; broad-band insecticides, broad-band acaricides and nematicides; and also the well known anthelminthics and insect- and/or acarid-deterring substances, said repellents or detachers. 
     Non-limitative examples of suitable insecticides and acaricides are: 
     
       
         
           
               
               
             
               
                   
               
             
            
               
                 1. 
                 Abamectin 
               
               
                 2. 
                 AC 303 630 
               
               
                 3. 
                 Acephat 
               
               
                 4. 
                 Acrinathrin 
               
               
                 5. 
                 Alanycarb 
               
               
                 6. 
                 Aldicarb 
               
               
                 7. 
                 α-Cypermethrin 
               
               
                 8. 
                 Alphamethrin 
               
               
                 9. 
                 Amitraz 
               
               
                 10. 
                 Avermectin B 1   
               
               
                 11. 
                 AZ 60541 
               
               
                 12. 
                 Azinphos A 
               
               
                 13. 
                 Azinphos M 
               
               
                 14. 
                 Azinphos-methyl 
               
               
                 15. 
                 Azocyclotin 
               
               
                 16. 
                   Bacillus  subtil. toxin 
               
               
                 17. 
                 Bendiocarb 
               
               
                 18. 
                 Benfuracarb 
               
               
                 19. 
                 Bensultap 
               
               
                 20. 
                 β-Cyfluthrin 
               
               
                 21. 
                 Bifenthrin 
               
               
                 22. 
                 BPMC 
               
               
                 23. 
                 Brofenprox 
               
               
                 24. 
                 Bromophos A 
               
               
                 25. 
                 Bufencarb 
               
               
                 26. 
                 Buprofezin 
               
               
                 27. 
                 Butocarboxin 
               
               
                 28. 
                 Butylpyridaben 
               
               
                 29. 
                 Cadusafos 
               
               
                 30. 
                 Carbaryl 
               
               
                 31. 
                 Carbofuran 
               
               
                 32. 
                 Carbophenthion 
               
               
                 33. 
                 Cartap 
               
               
                 34. 
                 Chloethocarb 
               
               
                 35. 
                 Chlorethoxyfos 
               
               
                 36. 
                 Chlorfenapyr 
               
               
                 37. 
                 Chlorfluazuron 
               
               
                 38. 
                 Chlormephos 
               
               
                 39. 
                 Chlorpyrifos 
               
               
                 40. 
                 Cis-Resmethrin 
               
               
                 41. 
                 Clocythrin 
               
               
                 42. 
                 Clofentezin 
               
               
                 43. 
                 Cyanophos 
               
               
                 44. 
                 Cycloprothrin 
               
               
                 45. 
                 Cyfluthrin 
               
               
                 46. 
                 Cyhexatin 
               
               
                 47. 
                 D 2341 
               
               
                 48. 
                 Deltamethrin 
               
               
                 49. 
                 Demeton M 
               
               
                 50. 
                 Demeton S 
               
               
                 51. 
                 Demeton-S-methyl 
               
               
                 52. 
                 Dibutylaminothio 
               
               
                 53. 
                 Dichlofenthion 
               
               
                 54. 
                 Dicliphos 
               
               
                 55. 
                 Diethion 
               
               
                 56. 
                 Diflubenzuron 
               
               
                 57. 
                 Dimethoat 
               
               
                 58. 
                 Dimethylvinphos 
               
               
                 59. 
                 Dioxathion 
               
               
                 60. 
                 DPX-MP062 
               
               
                 61. 
                 Edifenphos 
               
               
                 62. 
                 Emamectin 
               
               
                 63. 
                 Endosulfan 
               
               
                 64. 
                 Esfenvalerat 
               
               
                 65. 
                 Ethiofencarb 
               
               
                 66. 
                 Ethion 
               
               
                 67. 
                 Ethofenprox 
               
               
                 68. 
                 Ethoprophos 
               
               
                 69. 
                 Etrimphos 
               
               
                 70. 
                 Fenamiphos 
               
               
                 71. 
                 Fenazaquin 
               
               
                 72. 
                 Fenbutatinoxid 
               
               
                 73. 
                 Fenitrothion 
               
               
                 74. 
                 Fenobucarb 
               
               
                 75. 
                 Fenothiocarb 
               
               
                 76. 
                 Fenoxycarb 
               
               
                 77. 
                 Fenpropathrin 
               
               
                 78. 
                 Fenpyrad 
               
               
                 79. 
                 Fenpyroximate 
               
               
                 80. 
                 Fenthion 
               
               
                 81. 
                 Fenvalerate 
               
               
                 82. 
                 Fipronil 
               
               
                 83. 
                 Fluazinam 
               
               
                 84. 
                 Fluazuron 
               
               
                 85. 
                 Flucycloxuron 
               
               
                 86. 
                 Flucythrinat 
               
               
                 87. 
                 Flufenoxuron 
               
               
                 88. 
                 Flufenprox 
               
               
                 89. 
                 Fonophos 
               
               
                 90. 
                 Formothion 
               
               
                 91. 
                 Fosthiazat 
               
               
                 92. 
                 Fubfenprox 
               
               
                 93. 
                 HCH 
               
               
                 94. 
                 Heptenophos 
               
               
                 95. 
                 Hexaflumuron 
               
               
                 96. 
                 Hexythiazox 
               
               
                 97. 
                 Hydroprene 
               
               
                 98. 
                 Imidacloprid 
               
               
                 99. 
                 insect-active 
               
               
                   
                 fungi 
               
               
                 100. 
                 insect-active 
               
               
                   
                 nematodes 
               
               
                 101. 
                 insect-active 
               
               
                   
                 viruses 
               
               
                 102. 
                 Iprobenfos 
               
               
                 103. 
                 Isofenphos 
               
               
                 104. 
                 Isoprocarb 
               
               
                 105. 
                 Isoxathion 
               
               
                 106. 
                 Ivermectin 
               
               
                 107. 
                 λ-Cyhalothrin 
               
               
                 108. 
                 Lufenuron 
               
               
                 109. 
                 Malathion 
               
               
                 110. 
                 Mecarbam 
               
               
                 111. 
                 Mesulfenphos 
               
               
                 112. 
                 Metaldehyd 
               
               
                 113. 
                 Methamidophos 
               
               
                 114. 
                 Methiocarb 
               
               
                 115. 
                 Methomyl 
               
               
                 116. 
                 Methoprene 
               
               
                 117. 
                 Metolcarb 
               
               
                 118. 
                 Mevinphos 
               
               
                 119. 
                 Milbemectin 
               
               
                 120. 
                 Moxidectin 
               
               
                 121. 
                 Naled 
               
               
                 122. 
                 NC 184 
               
               
                 123. 
                 NI-25, Acetamiprid 
               
               
                 124. 
                 Nitenpyram 
               
               
                 125. 
                 Omethoat 
               
               
                 126. 
                 Oxamyl 
               
               
                 127. 
                 Oxydemethon M 
               
               
                 128. 
                 Oxydeprofos 
               
               
                 129. 
                 Parathion 
               
               
                 130. 
                 Parathion-methyl 
               
               
                 131. 
                 Permethrin 
               
               
                 132. 
                 Phenthoat 
               
               
                 133. 
                 Phorat 
               
               
                 134. 
                 Phosalone 
               
               
                 135. 
                 Phosmet 
               
               
                 136. 
                 Phoxim 
               
               
                 137. 
                 Pirimicarb 
               
               
                 138. 
                 Pirimiphos A 
               
               
                 139. 
                 Pirimiphos M 
               
               
                 140. 
                 Promecarb 
               
               
                 141. 
                 Propaphos 
               
               
                 142. 
                 Propoxur 
               
               
                 143. 
                 Prothiofos 
               
               
                 144. 
                 Prothoat 
               
               
                 145. 
                 Pyrachlophos 
               
               
                 146. 
                 Pyradaphenthion 
               
               
                 147. 
                 Pyresmethrin 
               
               
                 148. 
                 Pyrethrum 
               
               
                 149. 
                 Pyridaben 
               
               
                 150. 
                 Pyrimidifen 
               
               
                 151. 
                 Pyriproxyfen 
               
               
                 152. 
                 RH 5992 
               
               
                 153. 
                 RH-2485 
               
               
                 154. 
                 Salithion 
               
               
                 155. 
                 Sebufos 
               
               
                 156. 
                 Silafluofen 
               
               
                 157. 
                 Spinosad 
               
               
                 158. 
                 Sulfotep 
               
               
                 159. 
                 Sulprofos 
               
               
                 160. 
                 Tebufenozide 
               
               
                 161. 
                 Tebufenpyrad 
               
               
                 162. 
                 Tebupirimphos 
               
               
                 163. 
                 Teflubenzuron 
               
               
                 164. 
                 Tefluthrin 
               
               
                 165. 
                 Temephos 
               
               
                 166. 
                 Terbam 
               
               
                 167. 
                 Terbufos 
               
               
                 168. 
                 Tetrachlorvinphos 
               
               
                 169. 
                 Thiafenox 
               
               
                 170. 
                 Thiodicarb 
               
               
                 171. 
                 Thiofanox 
               
               
                 172. 
                 Thionazin 
               
               
                 173. 
                 Thuringiensin 
               
               
                 174. 
                 Tralomethrin 
               
               
                 175. 
                 Triarthen 
               
               
                 176. 
                 Triazamate 
               
               
                 177. 
                 Triazophos 
               
               
                 178. 
                 Triazuron 
               
               
                 179. 
                 Trichlorfon 
               
               
                 180. 
                 Triflumuron 
               
               
                 181. 
                 Trimethacarb 
               
               
                 182. 
                 Vamidothion 
               
               
                 183. 
                 XMC (3,5,-Xylyl- 
               
               
                   
                 methylcarbamate) 
               
               
                 184. 
                 Xylylcarb 
               
               
                 185. 
                 YI 5301/5302 
               
               
                 186. 
                 ζ-Cypermethrin 
               
               
                 187. 
                 Zetamethrin 
               
               
                   
               
            
           
         
       
     
     Non-limitative examples of suitable anthelminthics are named in the following, a few representatives have insecticidal and acaricidal activity in addition to the anthelminthic activity, and are partly already in the above list.
     (A1) Praziguantel=2-cyclohexylcarbonyl-4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-α]isoquinoline   (A2) Closantel=3,5-diiodo-N-[5-chloro-2-methyl-4-(a-cyano-4-chlorobenzyl)phenyl]salicylamide   (A3) Triclabendazole=5-chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole   (A4) Levamisol=L-(−)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1b]thiazole   (A5) Mebendazole=(5-benzoyl-1H-benzimidazol-2-yl)carbaminic acid methyl ester   (A6) Omphalotin=a macrocyclic fermentation product of the fungus  Omphalotus olearius  described in WO 97/20857   (A7) Abamectin=avermectin B1   (A8) Ivermectin=22,23-dihydroavermectin B1   (A9) Moxidectin=5-O-demethyl-28-deoxy-25-(1,3-dimethyl-1-butenyl)-6,28-epoxy-23-(methoxyimino)-milbemycine B   (A10) Doramectin=25-cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)-avermectin Ala   (A11) Milbemectin=mixture of milbemycin A3 and milbemycin A4   (A12) Milbemycinoxim=5-oxime of milbemectin   

     Non-limitative examples of suitable repellents and detachers are: 
     (R1) DEET (N,N-diethyl-m-toluamide) 
     (R2) KBR 3023 N-butyl-2-oxycarbonyl-(2-hydroxy)-piperidine 
     (R3) Cymiazole=N,-2,3-dihydro-3-methyl-1,3-thiazol-2-ylidene-2,4-xylidene 
     The said partners in the mixture are best known to specialists in this field. Most are described in various editions of the Pesticide Manual, The British Crop Protection Council, London, and others in the various editions of The Merck Index, Merck &amp; Co., Inc., Rahway, N.J., USA or in patent literature. Therefore, the following listing is restricted to a few places where they may be found by way of example.
     (I) 2-Methyl-2-(methylthio)propionaldehyde-O-methylcarbamoyloxime (Aldicarb), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 26;   (II) S-(3,4-dihydro-4-oxobenzo[d]-[1,2,3]-triazin-3-ylmethyl)O,O-dimethyl-phosphorodithioate (Azinphos-methyl), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 67;   (III) Ethyl-N-[2,3-dihydro-2,2-dimethylbenzofuran-7-yloxycarbonyl-(methyl)aminothio]-N-isopropyl-β-alaninate (Benfuracarb), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 96;   (IV) 2-Methylbiphenyl-3-ylmethyl-(Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate (Bifenthrin), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 118;   (V) 2-tert-butylimino-3-isopropyl-5-phenyl-1,3,5-thiadiazin-4-one (Buprofezin), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 157;   (VI) 2,3-Dihydro-2,2-dimethylbenzofuran-7-yl-methylcarbamate (Carbofuran), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 186;   (VII) 2,3-Dihydro-2,2-dimethylbenzofuran-7-yl-(dibutylaminothio)methylcarbamate (Carbosulfan), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 188;   (VIII) S,S′-(2-dimethylaminotrimethylene)-bis(thiocarbamate) (Cartap), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 193;   (IX) 1-[3,5-Dichloro-4-(3-chloro-5-trifluoromethyl-2-pyridyloxy)phenyl]-3-(2,6-difluorobenzoyl)-urea (Chlorfluazuron), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 213;   (X) O,O-diethyl-O-3,5,6-trichloro-2-pyridyl-phosphorothioate (Chlorpyrifos), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 235;   (XI) (RS)-α-cyano-4-fluoro-3-phenoxybenzyl-(1RS,3RS; 1RS,3RS)-3-(2,2-dichlorovinyl)-2,2-di-methylcyclopropanecarboxylate (Cyfluthrin), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 293;   (XII) Mixture of (S)-α-cyano-3-phenoxybenzyl-(Z)-(1R,3R)-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarboxylate and (R)-α-cyano-3-phenoxybenzyl-(Z)-(1R,3R)-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarboxylate (Lambda-Cyhalothrin), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 300;   (XIII) Racemate consisting of (S)-α-cyano-3-phenoxybenzyl-(Z)-(1R,3R)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate and (R)-α-cyano-3-phenoxybenzyl-(1S,3S)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate (Alpha-cypermethrin), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 308;   (XIV) a mixture of the stereoisomers of (S)-α-cyano-3-phenoxybenzyl (1RS,3RS,-1RS,3RS)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate (zeta-Cypermethrin), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 314;   (XV) (S)-α-cyano-3-phenoxybenzyl-(1R,3R)-3-(2,2-dibromovinyl)-2,2-dimethylcyclopropane-carboxylate (Deltamethrin), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 344;   (XVI) (4-chlorophenyl)-3-(2,6-difluorobenzoyl)urea (Diflubenzuron), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 395;   (XVII) (1,4,5,6,7,7-Hexachloro-8,9,10-trinorborn-5-en-2,3-ylenebismethylene)-sulphite (Endosulfan), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 459;   (XVIII) α-ethylthio-o-tolyl-methylcarbamate (Ethiofencarb), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 479;   (XIX) O,O-dimethyl-O-4-nitro-m-tolyl-phosphorothioate (Fenitrothion), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 514;   (XX) 2-sec-butylphenyl-methylcarbamate (Fenobucarb), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 516;   (XXI) (RS)-α-cyano-3-phenoxybenzyl-(RS)-2-(4-chlorophenyl)-3-methylbutyrate (Fenvalerate), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 539;   (XXII) S-[formyl(methyl)carbamoylmethyl]-O,O-dimethyl-phosphorodithioate (Formothion), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 625;   (XXIII) 4-Methylthio-3,5-xylyl-methylcarbamate (Methiocarb), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 813;   (XXIV) 7-Chlorobicyclo[3.2.0]hepta-2,6-dien-6-yl-dimethylphosphate (Heptenophos), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 670;   (XXV) 1-(6-chloro-3-pyridylmethyl)-N-nitroimidazolidin-2-ylidenamine (Imidacloprid), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 706;   (XXVI) 2-isopropylphenyl-methylcarbamate (Isoprocarb), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 729;   (XXVII) O,S-dimethyl-phosphoramidothioate (Methamidophos), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 808;   (XXVIII) S-Methyl-N-(methylcarbamoyloxy)thioacetimidate (Methomyl), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 815;   (XXIX) Methyl-3-(dimethoxyphosphinoyloxy)but-2-enoate (Mevinphos), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 844;   (XXX) O,O-diethyl-O-4-nitrophenyl-phosphorothioate (Parathion), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 926;   (XXXI) O,O-dimethyl-O-4-nitrophenyl-phosphorothioate (Parathion-methyl), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 928;   (XXXII) S-6-chloro-2,3-dihydro-2-oxo-1,3-benzoxazol-3-ylmethyl-O,O-diethyl-phosphorodithioate (Phosalone), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 963;   (XXXIII) 2-Dimethylamino-5,6-dimethylpyrimidin-4-yl-dimethylcarbamate (Pirimicarb), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 985;   (XXXIV) 2-isopropoxyphenyl-methylcarbamate (Propoxur), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 1036;   (XXXV) 1-(3,5-dichloro-2,4-difluorophenyl)-3-(2,6-difluorobenzoyl)urea (Teflubenzuron), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 1158;   (XXXVI) S-tert-butylthiomethyl-O,O-dimethyl-phosphorodithioate (Terbufos), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 1165;   (XXXVII) ethyl-(3-tert.-butyl-1-dimethylcarbamoyl-1H-1,2,4-triazol-5-yl-thio)-acetate, (Triazamate), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 1224;   (XXXVIII) Abamectin, from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 3;   (XXXIX) 2-sec-butylphenyl-methylcarbamate (Fenobucarb), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 516;   (XL) N-tert.-butyl-N′-(4-ethylbenzoyl)-3,5-dimethylbenzohydrazide (Tebufenozide), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 1147;   (XLI) (±)-5-amino-1-(2,6-dichloro-α,α,α-trifluoro-p-tolyl)-4-trifluoromethyl-sulphinylpyrazol-3-carbonitrile (Fipronil), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 545;   (XLII) (RS)-α-cyano-4-fluoro-3-phenoxybenzyl(1RS,3RS; 1RS,3RS)-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylate (beta-Cyfluthrin), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 295;   (XLIII) (4-ethoxyphenyl)-[3-(4-fluoro-3-phenoxyphenyl)propyl](dimethyl)silane (Silafluofen), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 1105;   (XLIV) tert.-butyl (E)-α-(1,3-dimethyl-5-phenoxypyrazol-4-yl-methyleneamino-oxy)-p-toluate (Fenpyroximate), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 530;   (XLV) 2-tert.-butyl-5-(4-tert.-butylbenzylthio)-4-chloropyridazin-3(2H)-one (Pyridaben), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 1161;   (XLVI) 4-[[4-(1,1-dimethylphenyl)phenyl]ethoxy]-quinazoline (Fenazaquin), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 507;   (XLVII) 4-phenoxyphenyl-(RS)-2-(pyridyloxy)propyl-ether (Pyriproxyfen), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 1073;   (XLVIII) 5-chloro-N-{2-[4-(2-ethoxyethyl)-2,3-dimethylphenoxy]ethyl}-6-ethylpyrimidine-4-amine (Pyrimidifen), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 1070;   (XLIX) (E)-N-(6-chloro-3-pyridylmethyl)-N-ethyl-N′-methyl-2-nitrovinylidenediamine (Nitenpyram), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 880;   (L) (E)-N 1 -[(6-chloro-3-pyridyl)methyl]-N 2 -cyano-N 1 -methylacetamidine (NI-25, Acetamiprid), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 9;   (LI) Avermectin B 1 , from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 3;   (LII) an insect-active extract from a plant, especially (2R,6aS,12aS)-1,2,6,6a,12,12a-hexahydro-2-isopropenyl-8,9-dimethoxy-chromeno[3,4-b]furo[2,3-h]chromen-6-one (Rotenone), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 1097; and an extract from  Azadirachta indica , especially azadirachtin, from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 59; and   (LIII) a preparation which contains insect-active nematodes, preferably  Heterorhabditis bacteriophora  and  Heterorhabditis megidis , from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 671 ; Steinernema feltiae , from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 1115 and  Steinernema scapterisci , from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 1116;   (LIV) a preparation obtainable from  Bacillus subtilis , from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 72; or from a strain of  Bacillus thuringiensis  with the exception of compounds isolated from GC91 or from NCTC11821; The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 73;   (LV) a preparation which contains insect-active fungi, preferably  Verticillium lecanii , from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 1266;  Beauveria brogniartii , from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 85 and  Beauveria bassiana , from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 83;   (LVI) a preparation which contains insect-active viruses, preferably  Neodipridon Sertifer  NPV, from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 1342;  Mamestra brassicae  NPV, from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 759 and  Cydia pomonella granulosis  virus, from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 291;   (CLXXXI) 7-chloro-2,3,4a,5-tetrahydro-2-[methoxycarbonyl(4-trifluoromethoxyphenyl)-carbamoyl]indol[1,2e]oxazoline-4-a-carboxylate (DPX-MP062, Indoxycarb), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 453;   (CLXXXII) N′-tert.-butyl-N′-(3,5-dimethylbenzoyl)-3-methoxy-2-methylbenzohydrazide (RH-2485, Methoxyfenozide), from The Pesticide Manual, 11 th  Ed. (1997), The British Crop Protection Council, London, page 1094; and   (CLXXXIII) (N′-[4-methoxy-biphenyl-3-yl]-hydrazinecarboxylic acid isopropyl ester (D 2341), from Brighton Crop Protection Conference, 1996, 487-493;   (R2) Book of Abstracts, 212th ACS National Meeting Orlando, Fla., Aug. 25-29 (1996), AGRO-020. Publisher: American Chemical Society, Washington, D.C. CONEN: 63BFAF.   

     As a consequence of the above details, a further essential aspect of the present invention relates to combination preparations for the control of parasites on warm-blooded animals, characterised in that they contain, in addition to a compound of formula I, at least one further active ingredient having the same or different sphere of activity and at least one physiologically acceptable carrier. The present invention is not restricted to two-fold combinations. 
     As a rule, the compositions according to the invention contain 0.1 to 99% by weight, especially 0.1 to 95% by weight of active ingredient of formula I, Ia or mixtures thereof, 99.9 to 1% by weight, especially 99.8 to 5% by weight of a solid or liquid admixture, including 0 to 25% by weight, especially 0.1 to 25% by weight of a surfactant. 
     Application of the compositions according to the invention to the animals to be treated may take place topically, perorally, parenterally or subcutaneously, the composition being present in the form of solutions, emulsions, suspensions, (drenches), powders, tablets, boli, capsules and pour-on formulations. 
     The pour-on or spot-on method consists in applying the compound of formula I to a specific location of the skin or coat, advantageously to the neck or backbone of the animal. This takes place e.g. by applying a swab or spray of the pour-on or spot-on formulation to a relatively small area of the coat, from where the active substance is dispersed almost automatically over wide areas of the fur owing to the spreading nature of the components in the formulation and assisted by the animal&#39;s movements. 
     Pour-on or spot-on formulations suitably contain carriers, which promote rapid dispersement over the skin surface or in the coat of the host animal, and are generally regarded as spreading oils. Suitable carriers are e.g. oily solutions; alcoholic and isopropanolic solutions such as solutions of 2-octyldodecanol or oleyl alcohol; solutions in esters of monocarboxylic acids, such as isopropyl myristate, isopropyl palmitate, lauric acid oxalate, oleic acid oleyl ester, oleic acid decyl ester, hexyl laurate, oleyl oleate, decyl oleate, capric acid esters of saturated fat alcohols of chain length C 12 -C 18 ; solutions of esters of dicarboxylic acids, such as dibutyl phthalate, diisopropyl isophthalate, adipic acid diisopropyl ester, di-n-butyl adipate or also solutions of esters of aliphatic acids, e.g. glycols. It may be advantageous for a dispersing agent to be additionally present, such as one known from the pharmaceutical or cosmetic industry. Examples are 2-pyrrolidone, 2-(N-alkyl)pyrrolidone, acetone, polyethylene glycol and the ethers and esters thereof, propylene glycol or synthetic triglycerides. 
     The oily solutions include e.g. vegetable oils such as olive oil, groundnut oil, sesame oil, pine oil, linseed oil or castor oil. The vegetable oils may also be present in epoxidised form. Paraffins and silicone oils may also be used. 
     A pour-on or spot-on formulation generally contains 1 to 20% by weight of a compound of formula I, 0.1 to 50% by weight of dispersing agent and 45 to 98.9% by weight of solvent. 
     The pour-on or spot-on method is especially advantageous for use on herd animals such as cattle, horses, sheep or pigs, in which it is difficult or time-consuming to treat all the animals orally or by injection. Because of its simplicity, this method can of course also be used for all other animals, including individual domestic animals or pets, and is greatly favoured by the keepers of the animals, as it can often be carried out without the specialist presence of the veterinarian. 
     Whereas it is preferred to formulate commercial products as concentrates, the end user will normally use dilute formulations. 
     Such compositions may also contain further additives, such as stabilisers, anti-foaming agents, viscosity regulators, binding agents or tackifiers, as well as other active ingredients, in order to achieve special effects. 
     Compositions of this type, which are used by the end user, similarly form a constituent of the present invention. 
     In each of the processes according to the invention for pest control or in each of the pest control compositions according to the invention, the active ingredients of formula I can be used in all of their steric configurations or in mixtures thereof. 
     The invention also includes a method of prophylactically protecting warm-blooded animals, especially productive livestock, domestic animals and pets, against parasitic pests, which is characterised in that the active ingredients of formula or the active ingredient formulations prepared therefrom are administered to the animals as an additive to the feed, or to the drinks or also in solid or liquid form, orally or by injection or parenterally. The invention also includes the compounds of formula I according to the invention for usage in one of the said processes. 
     The following examples serve merely to illustrate the invention without restricting it, the term active ingredient representing a substance listed in table 1. 
     In particular, preferred formulations are made up as follows: 
     (%=percent by weight) 
    
    
     FORMULATION EXAMPLES 
       
     
       
         
           
               
               
               
               
             
               
                   
                   
               
               
                   
                 1. Granulate 
                 a) 
                 b) 
               
               
                   
                   
               
             
            
               
                   
                 active ingredient 
                 5% 
                 10% 
               
               
                   
                 kaolin 
                 94%  
                 — 
               
               
                   
                 highly dispersed silicic acid 
                 1% 
                 — 
               
               
                   
                 attapulgite 
                 — 
                 90% 
               
               
                   
                   
               
            
           
         
       
     
     The active ingredient is dissolved in methylene chloride, sprayed onto the carrier and the solvent subsequently concentrated by evaporation under vacuum. Granulates of this kind can be mixed with the animal feed. 
     
       
         
           
               
             
               
                   
               
               
                 2. Granulate 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                 active ingredient 
                 3% 
               
               
                   
                 polyethylene glycol (mw 200) 
                 3% 
               
               
                   
                 kaolin 
                 94%  
               
               
                   
                   
               
               
                   
                 (mw = molecular weight) 
               
            
           
         
       
     
     The finely ground active ingredient is evenly applied in a mixer to the kaolin which has been moistened with polyethylene glycol. In this way, dust-free coated granules are obtained. 
     
       
         
           
               
             
               
                   
               
               
                 3. Tablets or boli 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 I 
                 active ingredient 
                 33.00% 
               
               
                   
                   
                 methylcellulose 
                 0.80% 
               
               
                   
                   
                 silicic acid, highly dispersed 
                 0.80% 
               
               
                   
                   
                 corn starch 
                 8.40% 
               
               
                   
                 II 
                 lactose, cryst. 
                 22.50% 
               
               
                   
                   
                 corn starch 
                 17.00% 
               
               
                   
                   
                 microcryst. cellulose 
                 16.50% 
               
               
                   
                   
                 magnesium stearate 
                 1.00% 
               
               
                   
                   
               
            
           
         
       
         
         I Methyl cellulose is stirred into water. After the material has swollen, silicic acid is stirred in and the mixture homogeneously suspended. The active ingredient and the corn starch are mixed. The aqueous suspension is worked into this mixture and kneaded to a dough. The resulting mass is granulated through a 12 M sieve and dried. 
         II All 4 excipients are mixed thoroughly. 
         III The preliminary mixes obtained according to I and II are mixed and pressed into tablets or boli. 
       
    
     
       
         
           
               
             
               
                   
               
               
                 4. Injectables 
               
               
                 A. Oily vehicle (slow release) 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 1. 
                 active ingredient 
                 0.1-1.0 
                 g 
               
               
                   
                   
                 groundnut oil 
                 ad 100 
                 ml 
               
               
                   
                 2. 
                 active ingredient 
                 0.1-1.0 
                 g 
               
               
                   
                   
                 sesame oil 
                 ad 100 
                 ml 
               
               
                   
                   
               
            
           
         
       
     
     Preparation: The active ingredient is dissolved in part of the oil whilst stirring and, if required, with gentle heating, then after cooling made up to the desired volume and sterile-filtered through a suitable membrane filter with a pore size of 0.22 mm. 
     
       
         
           
               
             
               
                   
               
               
                 B Water-miscible solvent (average rate of release) 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 active ingredient 
                 0.1-1.0 
                 g 
               
               
                   
                 4-hydroxymethyl-1,3-dioxolane (glycerol formal) 
                 40 
                 g 
               
               
                   
                 1,2-propanediol 
                 ad 100 
                 ml 
               
               
                   
                 active ingredient 
                 0.1-1.0 
                 g 
               
               
                   
                 glycerol dimethyl ketal 
                 40 
                 g 
               
               
                   
                 1,2-propanediol 
                 ad 100 
                 ml 
               
               
                   
                   
               
            
           
         
       
     
     Preparation: The active ingredient is dissolved in part of the solvent whilst stirring, made up to the desired volume and sterile-filtered through a suitable membrane filter with a pore size of 0.22 mm. 
     
       
         
           
               
             
               
                   
               
               
                 C. Aqueous solubilisate (rapid release) 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 1. 
                 active ingredient 
                 0.1-1.0 
                 g 
               
               
                   
                 polyethoxylated castor oil (40 ethylene oxide units) 
                 10 
                 g 
               
               
                   
                 1,2-propanediol 
                 20 
                 g 
               
               
                   
                 benzyl alcohol 
                 1 
                 g 
               
               
                   
                 aqua ad inject. 
                 ad 100 
                 ml 
               
               
                 2. 
                 active ingredient 
                 0.1-1.0 
                 g 
               
               
                   
                 polyethoxylated sorbitan monooleate 
                 8 
                 g 
               
               
                   
                 (20 ethylene oxide units) 
               
               
                   
                 4-hydroxymethyl-1,3-dioxolane (glycerol formal) 
                 20 
                 g 
               
               
                   
                 benzyl alcohol 
                 1 
                 g 
               
               
                   
                 aqua ad inject. 
                 ad 100 
                 ml 
               
               
                   
               
            
           
         
       
     
     Preparation: The active ingredient is dissolved in the solvents and the surfactant, and made up with water to the desired volume. Sterile filtration through an appropriate membrane filter of 0.22 mm pore size. 
     
       
         
           
               
             
               
                   
               
               
                 5. Pour on 
               
               
                   
               
             
            
               
                 A. 
               
            
           
           
               
               
               
               
            
               
                   
                 active ingredient 
                 5 
                 g 
               
               
                   
                 isopropyl myristate 
                 10 
                 g 
               
               
                   
                 isopropanol 
                 ad 100 
                 ml 
               
            
           
           
               
            
               
                 B 
               
            
           
           
               
               
               
               
            
               
                   
                 active ingredient 
                 2 
                 g 
               
               
                   
                 hexyl laurate 
                 5 
                 g 
               
               
                   
                 medium-chained triglyceride 
                 15 
                 g 
               
               
                   
                 ethanol 
                 ad 100 
                 ml 
               
            
           
           
               
            
               
                 C. 
               
            
           
           
               
               
               
               
            
               
                   
                 active ingredient 
                 2 
                 g 
               
               
                   
                 oleyl oleate 
                 5 
                 g 
               
               
                   
                 N-methyl-pyrrolidone 
                 40 
                 g 
               
               
                   
                 isopropanol 
                 ad 100 
                 ml 
               
               
                   
                   
               
            
           
         
       
     
     The aqueous systems may also preferably be used for oral and/or intraruminal application. 
     The compositions may also contain further additives, such as stabilisers, e.g. where appropriate epoxidised vegetable oils (epoxidised coconut oil, rapeseed oil, or soybean oil); antifoams, e.g. silicone oil, preservatives, viscosity regulators, binders, tackifiers, as well as fertilisers or other active ingredients to achieve special effects. 
     Further biologically active substances or additives, which are neutral towards the compounds of formula I and do not have a harmful effect on the host animal to be treated, as well as mineral salts or vitamins, may also be added to the described compositions. 
     The following examples serve to illustrate the invention. They do not limit the invention. The letter ‘h’ stands for hour. 
     Preparation Examples 
     Example 1 
     2-[1-(2,6-Dichloro-4-trifluoromethylphenyl)-1H-indol-3-yl]-1,1,1-trifluoropropane-2-ol 
     a) In 40 ml tetrahydrofuran 10 g 1H-indole are dissolved and cooled to −60° C. and treated with 15.4 ml trifluoroacetic acid anhydride. The mixture is allowed to warm to room temperature, where a precipitate is formed. The crystalline solid is filtered off, washed with water and dried in vacuo to give 2,2,2-trifluoro-1-(1H-indol-3-yl)-ethanone, which can be used without any further purification. 
     b) In 150 ml absolute N,N-dimethylformamide 16.8 g 2,2,2-trifluoro-1-(1H-indol-3-yl)-ethanone are dissolved and then 12.7 g dry potassium carbonate are added. Then, 22 g 3,5-dichloro-4-fluorobenzotrifluoride is added in one portion. The resulting suspension is stirred for 3 hours at 90° C. After removal of the solvent in vacuo the resulting residue is suspended in 300 ml diethyl ether, the suspension washed with water, the aqueous phase twice extracted with diethyl ether and the combined organic phases evaporated in vacuo to give 1-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indol-3-yl]-2,2,2-trifluoroethanone, which can be used without further purification. 
     c) In 500 ml absolute diethyl ether 33.5 g 1-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indol-3-yl]-2,2,2-trifluoroethanone are dissolved. 52.5 ml of a methyl magnesium bromide solution (3 molar, in diethyl ether) is added slowly while the reaction temperature is kept at −10° C. The mixture is allowed to warm up to 20° C. and is stirred for 2 hours. The reaction mixture is then treated with saturated ammonium chloride solution and the organic layer separated. The aqueous phase is extracted with diethyl ether and the combined organic phases dried over magnesium sulfate. After evaporation of the solvent the residue is purified by flash-chromatography with ethyl acetate/hexane (1:9). 
     d) If required the two enantiomers of the above given compound can be separated using the following HPLC procedure. A 10 mg/mL solution of the racemate in hexane/isopropanol (97:3) is injected on a Daicel CHIRALPACK® AD-H column. Elution with hexane/isopropanol (97:3) gave the first enriched enantiomer in a fraction eluting after 9 min. (ee=97%) and the second pure enantiomer (ee&gt;97%) in a fraction eluting after 11 min. 
     Example 2 
     2-[1-(2,6-Dichloro-4-trifluoromethyl-phenyl)-1H-indol-3-yl]-1,1,1,3,3,3-hexafluoro-propan-2-ol 
     a) In 1 ml hexafluoroacetone 100 mg 1H-indole are suspended and heated to 90° C. for 1 hour. After completion of the reaction the excess solvent is removed in vacuo to give 1,1,1,3,3,3-hexafluoro-2-(1H-indol-3-yl)-propan-2-ol, which is further reacted without further purification. 
     b) In 1 ml N,N-dimethylformamide, 88.2 mg 1,1,1,3,3,3-hexafluoro-2-(1H-indol-3-yl)-propan-2-ol are dissolved under a nitrogen atmosphere. Then, 86.6 mg 3,5-dichloro-4-fluorobenzotrifluoride, dissolved in 1 ml N,N-dimethylformamide, is added, followed by 50.9 mg potassium carbonate. The mixture is heated for 2 hours at 90° C. After cooling to room temperature 2 ml water/dichloromethane (1:1) is added and the mixture is stirred for 30 minutes and then poured into a filter cartridge, filled with ISOLUTE® HM-N. The cartridge is washed with 20 ml dichloromethane. After removal of the solvent the residue is purified by preparative reverse phase chromatography on a Daisogel C18-ODS AP column with a water/formic acid (10′000:1) to acetonitrile/formic acid (10′000:1) gradient. The title compound is isolated by removal of the solvent. 
     Example 3 
     2-[1-(2,6-Dichloro-4-trifluoromethyl-phenyl)-1H-indol-3-yl]-1,1-difluoro-1-chloro-propan-2-ol 
     a) In 3 ml dichloromethane 300 mg 1H-indole are dissolved and cooled to 0° C. Then, 2.82 ml diethyl aluminum chloride (1.8 M in toluene) is added and the mixture is stirred for 30 minutes at 0° C. Finally, 705 mg difluorochloroacetic acid chloride, dissolved in 4 ml dichloromethane, are slowly added while the reaction temperature is kept at 0° C. The mixture is stirred for 2.5 hours at 0° C., then quenched with water at the same temperature and finally transferred into a separation funnel, neutralized and extracted with a saturated solution of sodium bicarbonate, water and brine. The organic phase is dried over sodium sulfate. After filtration the organic phase is concentrated under reduced pressure and the intermediate product 2,2-difluoro-2-chloro-1-(1H-indol-3-yl)-ethanone is allowed to precipitate. After removal of the solvent 2,2-difluoro-2-chloro-1-(1H-indol-3-yl)-ethanone is isolated and used without further purification. 
     b) In 1 ml of N,N-dimethylformamide 200 mg 2,2-difluoro-2-chloro-1-(1H-indol-3-yl)-ethanone is dissolved under a nitrogen atmosphere. Then, 287 mg 3,5-dichloro-4-fluorobenzotrifluoride, dissolved in 7 ml N,N-dimethylformamide, is added, followed by 121 mg potassium carbonate. The mixture is heated for 12 hours at 80° C. After cooling to room temperature 5 ml water/dichloromethane (1:1) is added and the mixture is stirred for 30 minutes, then poured into a filter cartridge, filled with ISOLUTE® HM-N. The cartridge is washed with 100 ml dichloromethane. After removal of the solvent the residue is purified by preparative reverse phase chromatography on a Daisogel C18-ODS AP column with a water/formic acid (10′000:1) to acetonitrile/formic acid (10′000:1) gradient. The intermediate product 1-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indol-3-yl]-2,2-difluoro-2-chloroethanone is isolated by removal of the solvent. 
     c) In 2 ml absolute diethyl ether 87.5 mg 1-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indol-3-yl]-2,2-difluoro-2-chloroethanone is dissolved. Then, 132 μl of a methyl magnesium bromide solution (3M, in diethyl ether) is added slowly while the reaction temperature is kept at −10° C. The mixture is allowed to warm up to 20° C. while being stirred for 0.5 hours, then treated with a saturated ammonium chloride solution. The organic layer is separated, the aqueous phase extracted with diethyl ether and the combined organic phases finally dried over magnesium sulfate. After removal of the solvent the residue is purified by column-chromatography using an ethyl acetate/hexane gradient. The title compound is isolated by removal of the solvent. 
     Example 4 
     Acetic acid 1-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indol-3-yl]-2,2,2-trifluoro-1-methyl-ethyl ester 
     In 2 ml dichloromethane 27.2 mg acetic acid are dissolved and then 103.7 mg dicyclohexyl carbodiimide and a catalytical amount of 4-dimethylaminopyridine are added. The resulting suspension is stirred for 30 minutes, a solution of 100 mg 2-[1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-indol-3-yl]-1,1,1-trifluoropropane-2-ol in 1 ml dichloromethane is added and the mixture is stirred for 48 hours. After quenching with water and dichloromethane the mixture is filtered over a cartridge containing silica gel and ISOLUTE® HM-N. The cartridge containing ISOLUTE® HM-N is washed with 45 ml of dichloromethane. After removal of the solvent the residue is purified by preparative reverse phase chromatography on a Daisogel C18-ODS AP column with a water/formic acid (10′000:1) to acetonitrile/formic acid (10′000:1) gradient yielding the title compound. 
     Example 5 
     Hexanoic acid 1-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indol-3-yl]-2,2,2-trifluoro-1-methyl-ethyl ester 
     In a mixture of 0.5 ml dichloromethane/N,N-dimethylformamide (2:1, v/v) 100 mg 2-[1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-indol-3-yl]-1,1,1-trifluoropropane-2-ol are dissolved and treated with 5.7 mg sodium hydride. The mixture is allowed to react for 15 minutes. Then, 37.7 mg of hexanoic acid chloride, dissolved in 0.5 ml of dichloromethane, followed by 0.5 ml dichloromethane is added and stirred for 22 hours. The mixture is quenched with water and dichloromethane and filtered over a cartridge containing silica gel and ISOLUTE® HM-N. The cartridge containing ISOLUTE® HM-N is washed with 45 ml dichloromethane. After removal of the solvent the residue is purified by preparative reverse phase chromatography on a Daisogel C18-ODS AP column with a water/formic acid (10′000:1) to acetonitrile/formic acid (10′000:1) gradient. The title compound is isolated by removal of the solvent. 
     Example 6 
     1-(2,6-Dichloro-4-trifluoromethyl-phenyl)-3-(2,2,2-trifluoro-1-methoxy-1-methylethyl)-1H-indole 
     In 0.5 ml of a mixture of dichloromethane/N,N-dimethylformamide (2:1, v/v) 100 mg 2-[1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-indol-3-yl]-1,1,1-trifluoropropane-2-ol are dissolved, treated with 8.6 mg sodium hydride and stirred for 30 minutes. Then, 21 μl methyl iodide is added slowly and the mixture stirred for one hour. The reaction mixture is quenched with water and filtered over a cartridge containing silica gel and ISOLUTE® HM-N. The cartridge containing ISOLUTE® HM-N is washed with 20 ml of dichloromethane. After removal of the solvent the residue is purified by preparative reverse phase chromatography on a Daisogel C18-ODS AP column with a water/formic acid (10′000:1) to acetonitrile/formic acid (10′000:1) gradient. The title compound is isolated by removal of the solvent. 
     Example 7 
     4-{1-[1-(2,6-Dichloro-4-trifluoromethyl-phenyl)-1H-indol-3-yl]-2,2,2-trifluoro-1-methyl-ethoxymethyl}-benzonitrile 
     In 0.5 ml of a mixture of dichloromethane/N,N-dimethylformamide (2:1, v/v) 80 mg 2-[1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-indol-3-yl]-1,1,1-trifluoropropane-2-ol are dissolved, treated with 6.9 mg sodium hydride and 30 mg of potassium iodide and stirred for 40 minutes. Then, 54.2 mg 4-cyano benzyl bromide, dissolved in 0.5 ml dichloromethane, is slowly added and the mixture stirred for 3 hours at room temperature, followed by 12 hours stirring at 36° C. The reaction mixture is quenched with water and filtered over a cartridge containing silica gel and ISOLUTE® HM-N. The cartridge containing ISOLUTE® HM-N is washed with 60 ml dichloromethane. After removal of the solvent the residue is purified by preparative reverse phase chromatography on a Daisogel C18-ODS AP column with a water/formic acid (10′000:1) to acetonitrile/formic acid (10′000:1) gradient. The title compound is isolated by removal of the solvent. 
     Example 8 
     Carbonic acid 1-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-4-fluoro-1H-indol-3-yl]-2,2,2-trifluoro-1-methyl-ethyl ester isopropyl ester 
     In 1.5 ml of N,N-dimethyl formamide 150 mg 2-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-4-fluoro-1H-indol-3-yl]-1,1,1-trifluoro-propan-2-ol are dissolved and 8 mg solid sodium hydride is added. The reaction mixture is stirred at room temperature for 15 minutes. Then, 391 μl isopropylchloroformate (1 M in toluene) is added and the resulting mixture stirred for 16 hours. After this, an additional amount of 391 μl isopropylchloroformate is added and stirring is continued for 16 h. Finally, the reaction mixture is quenched with water and diluted with dichloromethane The mixture is filtered over a cartridge containing silica gel and ISOLUTE® HM-N. The cartridge containing ISOLUTE® HM-N is washed with 20 ml of dichloromethane. After removal of the solvent the residue is purified by preparative reverse phase chromatography on a Daisogel C18-ODS AP column with a water to acetonitrile gradient. The title compound is isolated by removal of the solvent. 
     Example 9 
     Hexyl-carbamic acid 1-[1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indol-3-yl]-2,2,2-trifluoro-1-methyl-ethyl ester 
     In 1 ml N,N-dimethylformamide 100 mg 2-[1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-indol-3-yl]-1,1,1-trifluoropropane-2-ol are dissolved and 32.2 mg hexyl isocyanate is added while the reaction is kept at room temperature. The reaction is stirred for 4 hours and then 2.5 mg of copper(I) chloride is added. After stirring for further 18 h, the reaction mixture is cooled to 0° C., quenched with water, diluted with dichloromethane and filtered over a cartridge containing silica gel and ISOLUTE® HM-N. The cartridge containing ISOLUTE® HM-N is washed with 25 ml dichloromethane. Removal of the solvent and recrystallisation from hexane yields the title compound. 
     Example 10 
     2-[1-(3-Chloro-5-trifluoromethylpyrid-2-yl)-1H-indol-3-yl]-1,1,1-trifluoropropane-2-ol 
     a) In 50 ml absolute diethyl ether 5 g 2,2,2-trifluoro-1-(1H-indol-3-yl)-ethanone are dissolved. 15.6 ml of a methyl magnesium bromide solution (3 molar, in diethyl ether) is added slowly while the reaction temperature is kept at −10° C. The mixture is allowed to warm up to 20° C. and is stirred for 2 hours. The reaction mixture is then treated with saturated ammonium chloride solution and the organic layer separated. The aqueous phase is extracted with diethyl ether and the combined organic phases dried over magnesium sulfate. The organic phase is evaporated in vacuo to give 1,1,1-trifluoro-2-(1H-indol-3-yl)-propan-2-ol, which is used without further purification. 
     b) In 4 ml absolute N,N-dimethylformamide 160 mg 1,1,1-trifluoro-2-(1H-indol-3-yl)-propan-2-ol are dissolved and then 111 mg dry potassium carbonate are added. Then, 174 mg 2,3-dichloro-5-trifluoromethylpyridin is added in one portion. The resulting suspension is stirred for 5 hours at 90° C. After cooling to room temperature 5 ml water/dichloromethane (1:1) is added and the mixture is stirred for 30 minutes, then poured into a filter cartridge, filled with ISOLUTE® HM-N. The cartridge is washed with 50 ml dichloromethane. After removal of the solvent the residue is purified by preparative reverse-phase chromatography on a Daisogel C18-ODS AP column with a water to acetonitrile gradient. The title compound is isolated by removal of the solvent. 
     Example 11 
     2-[1-(2,6-Dichloro-4-trifluoromethyl-phenyl)-1H-indol-3-yl]-1,1,1-trifluoro-butan-2-ol 
     a) In 6 ml absolute N,N-dimethylformamide 500 mg indole are dissolved and then 708 mg dry potassium carbonate are added. Then, 1.19 g 3,5-dichloro-4-fluorobenzotrifluoride are added in one portion. The resulting suspension is stirred for 18 hours at 90° C. After cooling to room temperature the mixture is concentrated, then separated between water and ethyl acetate. The organic phase is dried and concentrated to give the crude 1-(2,6-dichloro-4-trifluoromethylphenyl)-1H-indole, pure enough to be used in the next step. 
     b) To 300 mg of 1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indole in 4 ml THF cooled to −78° C. are added 210 mg of NBS. The reaction mixture is stirred for 2 h at −78° C. and then allowed to warm up to room temperature. 3 ml hexane and 0.05 ml pyridine are added and the resulting suspension is filtered. The filtrate is concentrated and purified by column-chromatography using an ethyl acetate/hexane gradient to give 3-bromo-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indole after removal of the solvent. 
     c) To a solution of 50 mg of 3-bromo-1-(2,6-dichloro-4-trifluoromethyl-phenyl)-1H-indole in 0.5 ml THF cooled to −78° C. is added dropwise 0.18 ml of nBuLi 1.6M solution in hexanes. The solution is stirred for 15 min. at −78° C. and 30 μl of trifluoromethyl ethanone are added. The mixture is stirred for an additional hour at −78° C. and then allowed to warm up slowly to room temperature. 
     A saturated NH4Cl solution is added and the mixture is extracted with ether. The organic phase is dried and evaporated. The residue is purified by column-chromatography using an ethyl acetate/hexane gradient to give the title compound. 
     The substances named in the following tables may also be prepared analogously to the above-described methods. The values of the melting points are indicated in ° C. The term “c-C 3 H 5 ” defines a cyclopropyl group. 
     
       
         
           
               
             
               
                 TABLE 1 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 No. 
                 X 
                 R 2   
                 R 3   
                 R 4   
                 R 5   
                 m.p. [° C.] 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 1.1 
                 CCl 
                 H 
                 H 
                 CF 3   
                 H 
                 Wax 
               
               
                 1.2 
                 CCl 
                 H 
                 H 
                 CClF 2   
                 Me 
                 Oil 
               
               
                 1.3 
                 CCl 
                 H 
                 H 
                 CF 2 CF 3   
                 Me 
                 Wax 
               
               
                 1.4 
                 CCl 
                 H 
                 C(O)-(2,6-Cl 2 -Ph) 
                 CF 3   
                 Me 
                  66-68 
               
               
                 1.5 
                 CCl 
                 H 
                 C(O)-(4-CN-Ph) 
                 CF 3   
                 Me 
                  94-96 
               
               
                 1.6 
                 CCl 
                 H 
                 C(O)-2-thienyl 
                 CF 3   
                 Me 
                 Oil 
               
               
                 1.7 
                 CCl 
                 H 
                 C(O)-4-piperonyl 
                 CF 3   
                 Me 
                  99-101 
               
               
                 1.8 
                 CCl 
                 H 
                 C(O)C(Me) 2 OC(O)Me 
                 CF 3   
                 Me 
                 144-146 
               
               
                 1.9 
                 CCl 
                 H 
                 C(O)CH 2 CH 2 Ph 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.10 
                 CCl 
                 H 
                 C(O)CH 2 CO 2 Me 
                 CF 3   
                 Me 
                 Oil 
               
               
                 1.11 
                 CCl 
                 H 
                 C(O)CMe 3   
                 CF 3   
                 Me 
                 Oil 
               
               
                 1.12 
                 CCl 
                 H 
                 C(O)-cyclopentyl 
                 CF 3   
                 Me 
                 Oil 
               
               
                 1.13 
                 CCl 
                 H 
                 C(O)Me 
                 CF 3   
                 Me 
                 138-140 
               
               
                 1.14 
                 CCl 
                 4-F 
                 C(O)Me 
                 CF 3   
                 Me 
                  60-64 
               
               
                 1.15 
                 CCl 
                 H 
                 C(O)-n-C 5 H 11   
                 CF 3   
                 Me 
                 Oil 
               
               
                 1.16 
                 CCl 
                 H 
                 C(O)NH-(3,4-Cl 2 -Ph) 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.17 
                 CCl 
                 H 
                 C(O)NH-(4-Cl-Ph) 
                 CF 3   
                 Me 
                 144-156 
               
               
                 1.18 
                 CCl 
                 H 
                 C(O)NH-(4-F-Ph) 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.19 
                 CCl 
                 H 
                 C(O)NH-(4-NMe 2 -Ph) 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.20 
                 CCl 
                 H 
                 C(O)NH-(4-OCF 3 -Ph) 
                 CF 3   
                 Me 
                 147-153 
               
               
                 1.21 
                 CCl 
                 H 
                 C(O)NH-(4-OCH 3 -Ph) 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.22 
                 CCl 
                 H 
                 C(O)NHCHMe 2   
                 CF 3   
                 Me 
                 123-131 
               
               
                 1.23 
                 CCl 
                 H 
                 C(O)NHCMe 3   
                 CF 3   
                 Me 
                  60-70 
               
               
                 1.24 
                 CCl 
                 H 
                 C(O)NHEt 
                 CF 3   
                 Me 
                 165-170 
               
               
                 1.25 
                 CCl 
                 H 
                 C(O)NH-n-C 6 H 13   
                 CF 3   
                 Me 
                 130-134 
               
               
                 1.26 
                 CCl 
                 4-F 
                 C(O)OCH(CH 3 ) 2   
                 CF 3   
                 Me 
                 130-135 
               
               
                 1.27 
                 CCl 
                 H 
                 C(O)OCH═CCl 2   
                 CF 3   
                 Me 
                 158-160 
               
               
                 1.28 
                 CCl 
                 H 
                 C(O)OCH 2 C≡CH 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.29 
                 CCl 
                 H 
                 C(O)OCH 2 CH═CH 2   
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.30 
                 CCl 
                 H 
                 C(O)OCH 2 Ph 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.31 
                 CCl 
                 H 
                 C(O)OCHMe 2   
                 CF 3   
                 Me 
                 Oil 
               
               
                 1.32 
                 CCl 
                 4-F 
                 C(O)OEt 
                 CF 3   
                 Me 
                 Oil 
               
               
                 1.33 
                 CCl 
                 H 
                 C(O)OEt 
                 CF 3   
                 Me 
                 Oil 
               
               
                 1.34 
                 CCl 
                 H 
                 C(O)OEt 
                 CF 3   
                 H 
                 Oil 
               
               
                 1.35 
                 CCl 
                 H 
                 C(O)Ph 
                 CF 3   
                 Me 
                 136-138 
               
               
                 1.36 
                 CCl 
                 H 
                 C(S)NH-(4-CF 3 -Ph) 
                 CF 3   
                 Me 
               
               
                 1.37 
                 CCl 
                 H 
                 C(S)NH-(4-F-Ph) 
                 CF 3   
                 Me 
               
               
                 1.38 
                 CCl 
                 H 
                 C(S)NHMe 
                 CF 3   
                 Me 
                  43-52 
               
               
                 1.39 
                 CCl 
                 H 
                 CH 2 -(2-Cl-Ph) 
                 CF 3   
                 Me 
                 127-135 
               
               
                 1.40 
                 CCl 
                 H 
                 CH 2 (4-CF 3 -Ph) 
                 CF 3   
                 Me 
                 Oil 
               
               
                 1.41 
                 CCl 
                 H 
                 CH 2 (4-CN-Ph) 
                 CF 3   
                 Me 
                 124-130 
               
               
                 1.42 
                 CCl 
                 H 
                 CH 2 CH═CH 2   
                 CF 3   
                 Me 
                 Oil 
               
               
                 1.43 
                 CCl 
                 H 
                 CH 2 -c-C 3 H 5   
                 CF 3   
                 Me 
                 Oil 
               
               
                 1.44 
                 CCl 
                 4-F 
                 CH 2 OCH 2 Ph 
                 CF 3   
                 Me 
                 Oil 
               
               
                 1.45 
                 CCl 
                 4-F 
                 CH 2 OCH 3   
                 CF 3   
                 Me 
                 Oil 
               
               
                 1.46 
                 CCl 
                 H 
                 CH 2 Ph 
                 CF 3   
                 Me 
                 131-138 
               
               
                 1.47 
                 CCl 
                 H 
                 H 
                 CF 3   
                 2-Isoprenyl 
                 160-162 
               
               
                 1.48 
                 CCl 
                 H 
                 H 
                 CF 3   
                 C≡CH 
                 Wax 
               
               
                 1.49 
                 CCl 
                 H 
                 H 
                 CF 3   
                 CF 3   
                 126-128 
               
               
                 1.50 
                 N 
                 H 
                 H 
                 CF 3   
                 CF 3   
                 Oil 
               
               
                 1.51 
                 CCl 
                 4-F 
                 H 
                 CF 3   
                 CF 3   
                 128-130 
               
               
                 1.52 
                 CCl 
                 H 
                 H 
                 CF 3   
                 CH(Me) 2   
                 109-111 
               
               
                 1.53 
                 CCl 
                 H 
                 H 
                 CF 3   
                 CH═CH 2   
                  93-95 
               
               
                 1.54 
                 CCl 
                 H 
                 H 
                 CF 3   
                 CH 2 CHMe 2   
               
               
                 1.55 
                 CCl 
                 H 
                 H 
                 CF 3   
                 CH 2 Ph 
                 Wax 
               
               
                 1.56 
                 CCl 
                 H 
                 H 
                 CF 3   
                 COOMe 
                 Oil 
               
               
                 1.57 
                 CCl 
                 H 
                 H 
                 CF 3   
                 cyclopentyl 
               
               
                 1.58 
                 CCl 
                 H 
                 H 
                 CF 3   
                 Et 
                 Wax 
               
               
                 1.59 
                 CCl 
                 H 
                 H 
                 CF 3   
                 Me 
                 113-116 
               
               
                 1.60 
                 N 
                 H 
                 H 
                 CF 3   
                 Me 
                 108-114 
               
               
                 1.61 
                 CH 
                 H 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.62 
                 CCl 
                 7-Me 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.63 
                 CCl 
                 7-F 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.64 
                 CCl 
                 7-Cl 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.65 
                 CCl 
                 7-OMe 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.66 
                 CCl 
                 6-F 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.67 
                 CCl 
                 6-CF 3   
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.68 
                 CCl 
                 6-Cl 
                 H 
                 CF 3   
                 Me 
                  54-56 
               
               
                 1.69 
                 CCl 
                 6-OMe 
                 H 
                 CF 3   
                 Me 
                 162-164 
               
               
                 1.70 
                 CCl 
                 6-Me 
                 H 
                 CF 3   
                 Me 
                 144-146 
               
               
                 1.71 
                 CCl 
                 5-OMe 
                 H 
                 CF 3   
                 Me 
                 135-137 
               
               
                 1.72 
                 CCl 
                 5-OCH 2 Ph 
                 H 
                 CF 3   
                 Me 
                 140-142 
               
               
                 1.73 
                 CCl 
                 5-NO 2   
                 H 
                 CF 3   
                 Me 
               
               
                 1.74 
                 CCl 
                 5-F 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.75 
                 CCl 
                 5-COOMe 
                 H 
                 CF 3   
                 Me 
                  95-98 
               
               
                 1.76 
                 CCl 
                 5-Cl 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.77 
                 CCl 
                 5-CN 
                 H 
                 CF 3   
                 Me 
                  75-78 
               
               
                 1.78 
                 CCl 
                 5-Me 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.79 
                 CCl 
                 4-OMe 
                 H 
                 CF 3   
                 Me 
                 128-130 
               
               
                 1.80 
                 CCl 
                 4-Me 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.81 
                 CCl 
                 4-F 
                 H 
                 CF 3   
                 Me 
                  92-94 
               
               
                 1.82 
                 CCl 
                 4-Cl 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.83 
                 CCl 
                 4-Br 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.84 
                 CCl 
                 H 
                 H 
                 CF 3   
                 n-C 8 H 17   
               
               
                 1.85 
                 CCl 
                 H 
                 H 
                 CF 3   
                 Ph 
                 173-175 
               
               
                 1.86 
                 CCl 
                 H 
                 Me 
                 CF 3   
                 Me 
                 170-174 
               
               
                 1.87 
                 CCl 
                 H 
                 n-Bu 
                 CF 3   
                 Me 
                 Oil 
               
               
                 1.88 
                 CCl 
                 H 
                 n-Pr 
                 CF 3   
                 Me 
                 Oil 
               
               
                 1.89 
                 CCl 
                 H 
                 H 
                 CHF 2   
                 Me 
                 Wax 
               
               
                 1.90 
                 CCl 
                 H 
                 H 
                 CHCl 2   
                 Me 
               
               
                 1.91 
                 CCl 
                 H 
                 H 
                 Me 
                 4-Piperonyl 
               
               
                 1.92 
                 CCl 
                 H 
                 H 
                 Me 
                 4-CF 3 -Ph 
                 145-147 
               
               
                 1.93 
                 CCl 
                 H 
                 H 
                 Me 
                 CHPr 2   
                 Wax 
               
               
                 1.94 
                 CCl 
                 H 
                 H 
                 Me 
                 H 
                 Wax 
               
               
                 1.95 
                 CCl 
                 H 
                 H 
                 Me 
                 Me 
                 Oil 
               
               
                 1.96 
                 CCl 
                 H 
                 H 
                 CF 3   
                 Ph 
               
               
                 1.97 
                 CCl 
                 4-COOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 1.98 
                 CCl 
                 6-COOMe 
                 H 
                 CF 3   
                 Me 
                 193-195 
               
               
                 1.99 
                 CCl 
                 7-COOMe 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.100 
                 CCl 
                 5-Br 
                 H 
                 CF 3   
                 Me 
                  41-46 
               
               
                 1.101 
                 CCl 
                 6-Br 
                 H 
                 CF 3   
                 Me 
                  69-72 
               
               
                 1.102 
                 CCl 
                 7-Br 
                 H 
                 CF 3   
                 Me 
               
               
                 1.103 
                 CCl 
                 5,6- 
                 H 
                 CF 3   
                 Me 
                 179-181 
               
               
                   
                   
                 (—OCH 2 O—) 
               
               
                 1.104 
                 CCl 
                 4-Me, 5-OMe 
                 H 
                 CF 3   
                 Me 
                 166-168 
               
               
                 1.105 
                 CCl 
                 5-OCH 2 Ph, 
                 H 
                 CF 3   
                 Me 
                 160-162 
               
               
                   
                   
                 6-OMe 
               
               
                 1.106 
                 CCl 
                 4-OCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 1.107 
                 CCl 
                 6-OCH 2 Ph 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.108 
                 CCl 
                 7-Et 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.109 
                 CCl 
                 6-CN 
                 H 
                 CF 3   
                 Me 
                 207-209 
               
               
                 1.110 
                 CCl 
                 4-CN 
                 H 
                 CF 3   
                 Me 
                 187-189 
               
               
                 1.111 
                 CCl 
                 5,6-di-F 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.112 
                 CCl 
                 4,6-di-F 
                 H 
                 CF 3   
                 Me 
                  74-76 
               
               
                 1.113 
                 CCl 
                 4,5,6,7-tetra-F 
                 H 
                 CF 3   
                 Me 
               
               
                 1.114 
                 CCl 
                 H 
                 H 
                 CF 3   
                 CO 2 H 
                  43-45 
               
               
                 1.115 
                 CCl 
                 H 
                 H 
                 CF 3   
                 CH 2 OH 
                 oil 
               
               
                 1.116 
                 CCl 
                 4-F 
                 CH 2 O(CH 2 ) 2 OMe 
                 CF 3   
                 Me 
                 oil 
               
               
                 1.117 
                 CCl 
                 4-F 
                 CH 2 OCH 2 CH 3   
                 CF 3   
                 Me 
                 oil 
               
               
                 1.118 
                 CCl 
                 4-F 
                 CH 2 O(4-Cl-Ph) 
                 CF 3   
                 Me 
                 oil 
               
               
                 1.119 
                 CCl 
                 H 
                 H 
                 COOEt 
                 COOEt 
                  84-86 
               
               
                 1.120 
                 CCl 
                 H 
                 H 
                 Me 
                 H 
                 Wax 
               
               
                 1.121 
                 CCl 
                 H 
                 Et 
                 Me 
                 H 
                 Oil 
               
               
                 1.122 
                 CCl 
                 7-NO 2   
                 H 
                 CF 3   
                 Me 
               
               
                 1.123 
                 CCl 
                 7-CN 
                 H 
                 CF 3   
                 Me 
               
               
                 1.124 
                 CCl 
                 6-NO 2   
                 H 
                 CF 3   
                 Me 
               
               
                 1.125 
                 CCl 
                 7-OH 
                 H 
                 CF 3   
                 Me 
               
               
                 1.126 
                 CCl 
                 7-NH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 1.127 
                 CCl 
                 6-OH 
                 H 
                 CF 3   
                 Me 
                 193-196 
               
               
                 1.128 
                 CCl 
                 6-NH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 1.129 
                 CCl 
                 5-OH 
                 H 
                 CF 3   
                 Me 
                  61-63 
               
               
                 1.130 
                 CCl 
                 5-NH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 1.131 
                 CCl 
                 4-OH 
                 H 
                 CF 3   
                 Me 
                  80-86 
               
               
                 1.132 
                 CCl 
                 4-NH 2   
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.133 
                 CCl 
                 4-NO 2   
                 H 
                 CF 3   
                 Me 
               
               
                 1.134 
                 N 
                 7-Me 
                 H 
                 CF 3   
                 Me 
               
               
                 1.135 
                 N 
                 7-F 
                 H 
                 CF 3   
                 Me 
               
               
                 1.136 
                 N 
                 7-Cl 
                 H 
                 CF 3   
                 Me 
               
               
                 1.137 
                 N 
                 7-OMe 
                 H 
                 CF 3   
                 Me 
               
               
                 1.138 
                 N 
                 6-F 
                 H 
                 CF 3   
                 Me 
                 109-112 
               
               
                 1.139 
                 N 
                 6-CF 3   
                 H 
                 CF 3   
                 Me 
               
               
                 1.140 
                 N 
                 6-Cl 
                 H 
                 CF 3   
                 Me 
               
               
                 1.141 
                 N 
                 6-OMe 
                 H 
                 CF 3   
                 Me 
               
               
                 1.142 
                 N 
                 6-Me 
                 H 
                 CF 3   
                 Me 
               
               
                 1.143 
                 N 
                 5-OMe 
                 H 
                 CF 3   
                 Me 
               
               
                 1.144 
                 N 
                 5-OCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 1.145 
                 N 
                 5-NO 2   
                 H 
                 CF 3   
                 Me 
               
               
                 1.146 
                 N 
                 5-F 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.147 
                 N 
                 5-COOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 1.148 
                 N 
                 5-Cl 
                 H 
                 CF 3   
                 Me 
               
               
                 1.149 
                 N 
                 5-CN 
                 H 
                 CF 3   
                 Me 
               
               
                 1.150 
                 N 
                 5-Me 
                 H 
                 CF 3   
                 Me 
               
               
                 1.151 
                 N 
                 4-OMe 
                 H 
                 CF 3   
                 Me 
               
               
                 1.152 
                 N 
                 4-Me 
                 H 
                 CF 3   
                 Me 
               
               
                 1.153 
                 N 
                 4-F 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.154 
                 N 
                 4-Cl 
                 H 
                 CF 3   
                 Me 
               
               
                 1.155 
                 N 
                 4-Br 
                 H 
                 CF 3   
                 Me 
               
               
                 1.156 
                 N 
                 4-COOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 1.157 
                 N 
                 6-COOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 1.158 
                 N 
                 7-COOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 1.159 
                 N 
                 5-Br 
                 H 
                 CF 3   
                 Me 
               
               
                 1.160 
                 N 
                 6-Br 
                 H 
                 CF 3   
                 Me 
               
               
                 1.161 
                 N 
                 7-Br 
                 H 
                 CF 3   
                 Me 
               
               
                 1.162 
                 N 
                 5,6(—OCH 2 O—) 
                 H 
                 CF 3   
                 Me 
               
               
                 1.163 
                 N 
                 4-Me, 5-OMe 
                 H 
                 CF 3   
                 Me 
               
               
                 1.164 
                 N 
                 5-OCH 2 Ph, 
                 H 
                 CF 3   
                 Me 
               
               
                   
                   
                 6-OMe 
               
               
                 1.165 
                 N 
                 4-OCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 1.166 
                 N 
                 6-OCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 1.167 
                 N 
                 7-Et 
                 H 
                 CF 3   
                 Me 
               
               
                 1.168 
                 N 
                 6-CN 
                 H 
                 CF 3   
                 Me 
               
               
                 1.169 
                 N 
                 4-CN 
                 H 
                 CF 3   
                 Me 
               
               
                 1.170 
                 N 
                 5,6-di-F 
                 H 
                 CF 3   
                 Me 
               
               
                 1.171 
                 N 
                 4,6-di-F 
                 H 
                 CF 3   
                 Me 
               
               
                 1.172 
                 N 
                 4,5,6,7-tetra-F 
                 H 
                 CF 3   
                 Me 
               
               
                 1.173 
                 N 
                 7-NO 2   
                 H 
                 CF 3   
                 Me 
               
               
                 1.174 
                 N 
                 7-CN 
                 H 
                 CF 3   
                 Me 
               
               
                 1.175 
                 N 
                 6-NO 2   
                 H 
                 CF 3   
                 Me 
               
               
                 1.176 
                 N 
                 7-OH 
                 H 
                 CF 3   
                 Me 
               
               
                 1.177 
                 N 
                 7-NH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 1.178 
                 N 
                 6-OH 
                 H 
                 CF 3   
                 Me 
               
               
                 1.179 
                 N 
                 6-NH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 1.180 
                 N 
                 5-OH 
                 H 
                 CF 3   
                 Me 
               
               
                 1.181 
                 N 
                 5-NH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 1.182 
                 N 
                 4-OH 
                 H 
                 CF 3   
                 Me 
               
               
                 1.183 
                 N 
                 4-NH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 1.184 
                 N 
                 4-NO 2   
                 H 
                 CF 3   
                 Me 
               
               
                 1.185 
                 CCl 
                 H 
                 H 
                 CF 3   
                 CH 2 NH(CH 2 ) 2 OCH 3   
                 oil 
               
               
                   
               
               
                 1.186 
                 CCl 
                 H 
                 H 
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 149-152 
               
               
                   
               
               
                 1.187 
                 CCl 
                 H 
                 H 
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 oil 
               
               
                   
               
               
                 1.188 
                 CCl 
                 4-CH 2 OH 
                 H 
                 CF 3   
                 Me 
                 oil 
               
               
                   
               
               
                 1.189 
                 CCl 
                 H 
                 H 
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 oil 
               
               
                   
               
               
                 1.190 
                 CCl 
                 H 
                 H 
                 CF 3   
                 CH 2 SCH 3   
                 oil 
               
               
                 1.191 
                 CCl 
                 H 
                 H 
                 CF 3   
                 C(O)CH 2 OCH 2 COOH 
                  68-70 
               
               
                   
               
               
                 1.192 
                 CCl 
                 H 
                 H 
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 175-176 
               
               
                   
               
               
                 1.193 
                 CCl 
                 H 
                 H 
                   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 oil 
               
               
                   
               
               
                 1.194 
                 CCl 
                 4-C(CH 3 ) 2 OH 
                 H 
                 CF 3   
                 Me 
                 157-161 
               
               
                 1.195 
                 CCl 
                 H 
                 H 
                 CF 3   
                 CH 2 OCH 3   
                 120-122 
               
               
                 1.196 
                 CCl 
                 H 
                 H 
                 CH(CH 3 ) 2   
                 CN 
                 123-125 
               
               
                 1.197 
                 CCl 
                 H 
                 H 
                 CH 3   
                 CN 
                 165-167 
               
               
                 1.198 
                 CCl 
                 H 
                 Si(CH 3 ) 3   
                 CH 3   
                 CN 
                 128-130 
               
               
                 1.199 
                 CCl 
                 H 
                 Si(CH 3 ) 3   
                 CH(CH 3 ) 2   
                 CN 
                 127-129 
               
               
                 1.200 
                 CCl 
                 H 
                 Si(CH 3 ) 3   
                 CF 3   
                 CN 
                 138-140 
               
               
                   
               
               
                 1.201 
                 CCl 
                 H 
                 H 
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 154-156 
               
               
                   
               
               
                 1.202 
                 CCl 
                 H 
                 H 
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 248-250 
               
               
                   
               
               
                 1.203 
                 CCl 
                 H 
                 H 
                 CF 3   
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 160-162 
               
               
                   
               
               
                 1.204 
                 CCl 
                 5-F 
                 H 
                 CF 3   
                 CF 3   
                 117-118 
               
               
                 1.205 
                 CCl 
                 7-F 
                 H 
                 CF 3   
                 CF 3   
                  80-92 
               
               
                 1.206 
                 CCl 
                 6-F 
                 H 
                 CF 3   
                 CF 3   
                 124-126 
               
               
                 1.207 
                 CCl 
                 6-F 
                 H 
                 CF 3   
                 CH═CH 2   
                 Wax 
               
               
                 1.208 
                 CCl 
                 H 
                 H 
                 Me 
                 2-thiazoyl 
                 143-145 
               
               
                 1.209 
                 CCl 
                 H 
                 Me 
                 Me 
                 CHMe 2   
                  84-86 
               
               
                 1.210 
                 CCl 
                 H 
                 H 
                 CF 3   
                 CH 2 Cl 
                 Wax 
               
               
                 1.211 
                 CCl 
                 5,6-di-OMe 
                 H 
                 CF 3   
                 Me 
                 178-180 
               
               
                 1.212 
                 CCl 
                 5-F, 6-Cl 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.213 
                 CCl 
                 5-Cl, 6-OMe 
                 H 
                 CF 3   
                 Me 
                 182-184 
               
               
                 1.214 
                 CCl 
                 5,6-di-Cl 
                 H 
                 CF 3   
                 Me 
                  62-65 
               
               
                 1.215 
                 CCl 
                 5-OH, 6-OMe 
                 H 
                 CF 3   
                 Me 
                 149-151 
               
               
                 1.216 
                 CCl 
                 4-F 
                 H 
                 CF 3   
                 CH═CH 2   
                 Wax 
               
               
                 1.217 
                 CCl 
                 5-F 
                 H 
                 CF 3   
                 CH═CH 2   
                 Wax 
               
               
                 1.218 
                 CCl 
                 7-Me 
                 H 
                 CF 3   
                 CH═CH 2   
                 Wax 
               
               
                 1.219 
                 CCl 
                 4-F 
                 H 
                 CF 3   
                 C≡CH 
                 103-105 
               
               
                 1.220 
                 CCl 
                 5-F 
                 H 
                 CF 3   
                 C≡CH 
                 Wax 
               
               
                 1.221 
                 CCl 
                 6-F 
                 H 
                 CF 3   
                 C≡CH 
                 139-141 
               
               
                 1.222 
                 CCl 
                 7-Me 
                 H 
                 CF 3   
                 C≡CH 
                 135-137 
               
               
                 1.223 
                 N 
                 H 
                 H 
                 CHF 2   
                 Me 
                 100-102 
               
               
                 1.224 
                 N 
                 H 
                 H 
                 CHF 2   
                 CH═CH 2   
                 oil 
               
               
                 1.225 
                 N 
                 H 
                 H 
                 CHF 2   
                 C≡CH 
                 123-125 
               
               
                 1.226 
                 CCl 
                 H 
                 H 
                 CHF 2   
                 CH═CH 2   
               
               
                 1.227 
                 CCl 
                 H 
                 H 
                 CHF 2   
                 C≡CH 
               
               
                 1.228 
                 CCl 
                 4-F, 7-Me 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.229 
                 CCl 
                 5-F, 7-Me 
                 H 
                 CF 3   
                 Me 
                 oil 
               
               
                 1.230 
                 CCl 
                 6-F, 7-Me 
                 H 
                 CF 3   
                 Me 
                 119-121 
               
               
                 1.231 
                 CCl 
                 5-I 
                 H 
                 CF 3   
                 Me 
                 oil 
               
               
                 1.232 
                 CCl 
                 4-NO 2   
                 H 
                 CF 3   
                 CO 2 Me 
                  83-85 
               
               
                 1.233 
                 CCl 
                 4-CO 2 H 
                 H 
                 CF 3   
                 Me 
                 177-179 
               
               
                 1.234 
                 CCl 
                 H 
                 H 
                 CF 3   
                 cyclopropyl 
                 oil 
               
               
                 1.235 
                 CCl 
                 H 
                 H 
                 CF 3   
                 2-thienyl 
                 oil 
               
               
                 1.236 
                 CCl 
                 H 
                 H 
                 CF 3   
                 CH 2 CH 2 OH 
                 116-118 
               
               
                 1.237 
                 CCl 
                 H 
                 H 
                 CF 3   
                 CH(OH)CH 3   
                 Wax 
               
               
                 1.238 
                 CCl 
                 4,6-di-F 
                 H 
                 CF 3   
                 CH═CH 2   
                 oil 
               
               
                 1.239 
                 CCl 
                 4,6-di-F 
                 H 
                 CF 3   
                 C≡CH 
                 oil 
               
               
                 1.240 
                 CCl 
                 H 
                 H 
                 CF 3   
                 4-CF 3 -Ph 
                 154-156 
               
               
                 1.241 
                 CCl 
                 H 
                 H 
                 CF 3   
                 4-CH 3 -Ph 
                  48-50 
               
               
                 1.242 
                 CCl 
                 5-Cl, 7-Me 
                 H 
                 CF 3   
                 Me 
                 159-160 
               
               
                 1.243 
                 CCl 
                 4,6-di-Cl 
                 H 
                 CF 3   
                 Me 
                  66-68 
               
               
                 1.244 
                 CNO 2   
                 H 
                 H 
                 CF 3   
                 Me 
                 oil 
               
               
                 1.245 
                 CCO 2 Me 
                 H 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.246 
                 CCl 
                 H 
                 H 
                 CF 3   
                 CH 2 CH═CH 2   
                 oil 
               
               
                 1.247 
                 CNH 2   
                 H 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.248 
                 CCO 2 H 
                 H 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.249 
                 CCONH 2   
                 H 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.250 
                 CCN 
                 H 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.251 
                 CCl 
                 H 
                 H 
                 CF 3   
                 CH═CHMe 
                 oil 
               
               
                 1.252 
                 CCl 
                 H 
                 H 
                 CF 3   
                 C≡CPh 
                 oil 
               
               
                 1.253 
                 CCl 
                 H 
                 H 
                 CF 3   
                 C≡Ccyclopropyl 
                 oil 
               
               
                 1.254 
                 N 
                 4-F 
                 H 
                 CF 3   
                 CH═CH 2   
                 Wax 
               
               
                 1.255 
                 N 
                 4-F 
                 H 
                 CF 3   
                 C≡CH 
                 Wax 
               
               
                 1.256 
                 N 
                 6-F 
                 H 
                 CF 3   
                 CH═CH 2   
                 Wax 
               
               
                 1.257 
                 N 
                 6-F 
                 H 
                 CF 3   
                 C≡CH 
                 140-144 
               
               
                 1.258 
                 N 
                 5-F 
                 H 
                 CF 3   
                 CH═CH 2   
                 Wax 
               
               
                 1.259 
                 N 
                 5-F 
                 H 
                 CF 3   
                 C≡CH 
                 128-133 
               
               
                 1.260 
                 CBr 
                 H 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.261 
                 Cl 
                 H 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                 1.262 
                 CC≡CH 
                 H 
                 H 
                 CF 3   
                 Me 
                 Wax 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
            
           
           
               
               
               
               
            
               
                 No. 
                 X 
                 R 6   
                 Phys. data 
               
               
                   
               
            
           
           
               
               
               
               
            
               
                 2.1 
                 CBr 
                 4-OCF 3   
                   
               
               
                 2.2 
                 CCF 3   
                 4-CN 
                 m.p: 138-140° 
               
               
                 2.3 
                 CCF 3   
                 6-CF 3   
               
               
                 2.4 
                 CCl 
                 4-CF 3   
                 Wax 
               
               
                 2.5 
                 CCl 
                 4-CHO 
               
               
                 2.6 
                 CCl 
                 4-Cl 
                 m.p: 42-45° 
               
               
                 2.7 
                 CCl 
                 4-CN 
                 m.p: 77-79° 
               
               
                 2.8 
                 CCl 
                 4-COMe 
               
               
                 2.9 
                 CCl 
                 4-COOMe 
               
               
                 2.10 
                 CCl 
                 4-Me 
               
               
                 2.11 
                 CCl 
                 4-NMe 2   
               
               
                 2.12 
                 CCl 
                 4-NO 2   
                 m.p: 79-84° 
               
               
                 2.13 
                 CCl 
                 4-Ph 
               
               
                 2.14 
                 CCl 
                 4-SO 3 H 
               
               
                 2.15 
                 CCl 
                 6-Cl 
                 Wax 
               
               
                 2.16 
                 CCl 
                 6-CN 
               
               
                 2.17 
                 CCl 
                 6-Me 
               
               
                 2.18 
                 CCl 
                 6-NO 2   
               
               
                 2.19 
                 CF 
                 4-CF 3   
                 m.p: 77-81° 
               
               
                 2.20 
                 CF 
                 4-CF 3 ; 6-F 
                 m.p: 93-95° 
               
               
                 2.21 
                 CH 
                 3,4-di-Cl 
               
               
                 2.22 
                 CH 
                 3,5-di-Cl 
               
               
                 2.23 
                 CH 
                 3,5-di-F 
               
               
                 2.24 
                 CH 
                 3-Br, 4-CF 3   
                 m.p: 94-97° 
               
               
                 2.25 
                 CH 
                 3-Br, 5-CF 3   
               
               
                 2.26 
                 CH 
                 3-CF 3 , 4-CN 
                 m.p: 147-149° 
               
               
                 2.27 
                 CH 
                 3-CN, 4-CF 3   
               
               
                 2.28 
                 CH 
                 3-CN, 5-CF 3   
               
               
                 2.29 
                 CH 
                 3-Me, 4-CF 3   
               
               
                 2.30 
                 CH 
                 3-Me, 5-CF 3   
               
               
                 2.31 
                 CH 
                 3-NO 2 , 4-CF 3   
               
               
                 2.32 
                 CH 
                 3-NO 2 , 5-CF 3   
               
               
                 2.33 
                 CH 
                 3-Cl-4-F 
               
               
                 2.34 
                 CNO 2   
                 4-CF 3   
                 m.p: 55-60° 
               
               
                 2.35 
                 COMe 
                 4-CN 
                 m.p: 64-66° 
               
               
                 2.36 
                 CH 
                 3,5-di-Me 
                 Wax 
               
               
                 2.37 
                 CCl 
                 4-SF 5   
               
               
                 2.38 
                 CCl 
                 4-SF 5 , 6-Cl 
                 m.p: 123-129° 
               
               
                 2.39 
                 N 
                 4-CF 3   
                 m.p: 84-86° 
               
               
                 2.40 
                 CCl 
                 3,5-di-F, 6-Cl 
                 m.p: 138-144° 
               
               
                 2.41 
                 CCl 
                 3-CN, 6-Cl 
                 m.p: 62-68° 
               
               
                 2.42 
                 CCl 
                 3,5-di-F, 4-CF 3 , 6-Cl 
                 oil 
               
               
                 2.43 
                 CCl 
                 3,4,5-tri-F, 6-Cl 
                 m.p: 100-108° 
               
               
                 2.44 
                 CCl 
                 4-NO 2 , 6-Cl 
                 Wax 
               
               
                 2.45 
                 CCl 
                 3-F, 6-Cl 
                 oil 
               
               
                 2.46 
                 CCl 
                 4-OCF 3 , 6-Cl 
                 Wax 
               
               
                 2.47 
                 CCl 
                 4-OCF 2 Cl, 6-Cl 
                 Wax 
               
               
                 2.48 
                 CCl 
                 4-I, 6-Cl 
                 Wax 
               
               
                 2.49 
                 CCl 
                 4-(4-CF 3 -Ph), 6-Cl 
                 Wax 
               
               
                 2.50 
                 CCl 
                 4-Cl, 6-Cl 
                 Wax 
               
               
                 2.51 
                 CCl 
                 4-NH 2 , 6-Cl 
                 Wax 
               
               
                 2.52 
                 CCl 
                 4-NHCOMe, 6-Cl 
                 m.p: 210-212° 
               
               
                 2.53 
                 CCl 
                 4-Br, 6-Cl 
                 Wax 
               
               
                 2.54 
                 CCl 
                 4-C≡CH, 6-Cl 
                 Wax 
               
               
                 2.55 
                 CCl 
                 4-CN, 6-Cl 
                 Wax 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 3 
               
             
            
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 No. 
                 X 
                 R 1   
                 R 2   
                 R 4   
                 R 5   
                 m.p. [° C.] 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 3.1 
                 CCl 
                 Me 
                 H 
                 CF 3   
                 Me 
                 121-124 
               
               
                 3.2 
                 CCl 
                 Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.3 
                 CCl 
                 iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.4 
                 CCl 
                 C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.5 
                 CCl 
                 c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.6 
                 CCl 
                 CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.7 
                 CCl 
                 Ph 
                 H 
                 CF 3   
                 Me 
                 130-132 
               
               
                 3.8 
                 CCl 
                 4-Cl-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.9 
                 CCl 
                 2-naphthyl 
                 H 
                 CF 3   
                 Me 
                 97-100 
               
               
                 3.10 
                 CCl 
                 3-Cl-4-F-Ph 
                 H 
                 CF 3   
                 Me 
                 81-83 
               
               
                 3.11 
                 CCl 
                 4-F-Ph 
                 H 
                 CF 3   
                 Me 
                 172-174 
               
               
                 3.12 
                 CCl 
                 2-pyridyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.13 
                 CCl 
                 2-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.14 
                 CCl 
                 5-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.15 
                 CCl 
                 2-pyrrolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.16 
                 CCl 
                 2-imidazolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.17 
                 CCl 
                 2-furanyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.18 
                 CCl 
                 OH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.19 
                 CCl 
                 OMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.20 
                 CCl 
                 OiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.21 
                 CCl 
                 OC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.22 
                 CCl 
                 O-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.23 
                 CCl 
                 OCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.24 
                 CCl 
                 OPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.25 
                 CCl 
                 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.26 
                 CCl 
                 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.27 
                 CCl 
                 O-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.28 
                 CCl 
                 O-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.29 
                 CCl 
                 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.30 
                 CCl 
                 SH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.31 
                 CCl 
                 SMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.32 
                 CCl 
                 SiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.33 
                 CCl 
                 SC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.34 
                 CCl 
                 S-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.35 
                 CCl 
                 SCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.36 
                 CCl 
                 SPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.37 
                 CCl 
                 NH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.38 
                 CCl 
                 NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.39 
                 CCl 
                 NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.40 
                 CCl 
                 NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.41 
                 CCl 
                 NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.42 
                 CCl 
                 NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.43 
                 CCl 
                 NHPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.44 
                 CCl 
                 NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.45 
                 CCl 
                 NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.46 
                 CCl 
                 NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.47 
                 CCl 
                 NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.48 
                 CCl 
                 NH-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.49 
                 CCl 
                 CH 2 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.50 
                 CCl 
                 CH 2 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.51 
                 CCl 
                 CH 2 O-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.52 
                 CCl 
                 CH 2 O-(2-(imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.53 
                 CCl 
                 CH 2 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.54 
                 CCl 
                 NHCH 2 -(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.55 
                 CCl 
                 NHCH 2 -(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.56 
                 CCl 
                 NHCH 2 -(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.57 
                 CCl 
                 NHCH 2 -(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.58 
                 CCl 
                 NHCH 2 -(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.59 
                 CCl 
                 CHO 
                 H 
                 CF 3   
                 Me 
                 108-112 
               
               
                 3.60 
                 CCl 
                 C(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.61 
                 CCl 
                 C(O)Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.62 
                 CCl 
                 C(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.63 
                 CCl 
                 C(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.64 
                 CCl 
                 C(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.65 
                 CCl 
                 C(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.66 
                 CCl 
                 C(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.67 
                 CCl 
                 C(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.68 
                 CCl 
                 C(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.69 
                 CCl 
                 C(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.70 
                 CCl 
                 C(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.71 
                 CCl 
                 C(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.72 
                 CCl 
                 COOH 
                 H 
                 CF 3   
                 Me 
                 113-118 
               
               
                 3.73 
                 CCl 
                 COOMe 
                 H 
                 CF 3   
                 Me 
                 130-132 
               
               
                 3.74 
                 CCl 
                 COOEt 
                 H 
                 CF 3   
                 Me 
               
               
                 3.75 
                 CCl 
                 COOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.76 
                 CCl 
                 COOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.77 
                 CCl 
                 COO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.78 
                 CCl 
                 COOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.79 
                 CCl 
                 COOPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.80 
                 CCl 
                 COO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.81 
                 CCl 
                 COO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.82 
                 CCl 
                 COO-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.83 
                 CCl 
                 COO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.84 
                 CCl 
                 COO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.85 
                 CCl 
                 CONH 2   
                 H 
                 CF 3   
                 Me 
                 oil 
               
               
                 3.86 
                 CCl 
                 C(O)NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.87 
                 CCl 
                 C(O)NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.88 
                 CCl 
                 C(O)NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.89 
                 CCl 
                 C(O)NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.90 
                 CCl 
                 C(O)NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.91 
                 CCl 
                 C(O)NHPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.92 
                 CCl 
                 C(O)NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.93 
                 CCl 
                 C(O)NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.94 
                 CCl 
                 C(O)NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.95 
                 CCl 
                 C(O)NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.96 
                 CCl 
                 C(O)NH-(2-furanyl)) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.97 
                 CCl 
                 NHC(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.98 
                 CCl 
                 NHC(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.99 
                 CCl 
                 NHC(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.100 
                 CCl 
                 NHC(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.101 
                 CCl 
                 NHC(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.102 
                 CCl 
                 NHC(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.103 
                 CCl 
                 NHC(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.104 
                 CCl 
                 NHC(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.105 
                 CCl 
                 NHC(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.106 
                 CCl 
                 NHC(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.107 
                 CCl 
                 NHC(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.108 
                 CCl 
                 NHCOOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.109 
                 CCl 
                 NHCOOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.110 
                 CCl 
                 NHCOOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.111 
                 CCl 
                 NHCOO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.112 
                 CCl 
                 NHCOOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.113 
                 CCl 
                 NHCOOPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.114 
                 CCl 
                 NHCOO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.115 
                 CCl 
                 NHCOO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.116 
                 CCl 
                 NHCOO-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.117 
                 CCl 
                 NHCOO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.118 
                 CCl 
                 NHCOO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.119 
                 CCl 
                 CN 
                 H 
                 CF 3   
                 Me 
               
               
                 3.120 
                 CCl 
                 NO 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.121 
                 CCl 
                 Cl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.122 
                 CCl 
                 CH 2 CH═CH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.123 
                 CCl 
                 CH 2 C≡CH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.124 
                 CCl 
                 Me 
                 5-Cl 
                 CF 3   
                 Me 
                 152-155 
               
               
                 3.125 
                 CCl 
                 Me 
                 5-OMe 
                 CF 3   
                 Me 
                 176-178 
               
               
                 3.126 
                 CH 
                 Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.127 
                 CH 
                 Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.128 
                 CH 
                 iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.129 
                 CH 
                 C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.130 
                 CH 
                 c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.131 
                 CH 
                 CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.132 
                 CH 
                 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.133 
                 CH 
                 4-Cl-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.134 
                 CH 
                 2-naphthyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.135 
                 CH 
                 3-Cl-4-F-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.136 
                 CH 
                 4-F-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.137 
                 CH 
                 2-pyridyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.138 
                 CH 
                 2-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.139 
                 CH 
                 5-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.140 
                 CH 
                 2-pyrrolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.141 
                 CH 
                 2-imidazolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.142 
                 CH 
                 2-furanyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.143 
                 CH 
                 OH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.144 
                 CH 
                 OMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.145 
                 CH 
                 OiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.146 
                 CH 
                 OC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.147 
                 CH 
                 O-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.148 
                 CH 
                 OCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.149 
                 CH 
                 OPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.150 
                 CH 
                 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.151 
                 CH 
                 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.152 
                 CH 
                 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.153 
                 CH 
                 O-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.154 
                 CH 
                 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.155 
                 CH 
                 SH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.156 
                 CH 
                 SMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.157 
                 CH 
                 SiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.158 
                 CH 
                 SC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.159 
                 CH 
                 S-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.160 
                 CH 
                 SCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.161 
                 CH 
                 SPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.162 
                 CH 
                 NH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.163 
                 CH 
                 NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.164 
                 CH 
                 NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.165 
                 CH 
                 NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.166 
                 CH 
                 NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.167 
                 CH 
                 NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.168 
                 CH 
                 NHPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.169 
                 CH 
                 NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.170 
                 CH 
                 NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.171 
                 CH 
                 NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.172 
                 CH 
                 NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.173 
                 CH 
                 NH-(2furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.174 
                 CH 
                 CH 2 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.175 
                 CH 
                 CH 2 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.176 
                 CH 
                 CH 2 O-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.177 
                 CH 
                 CH 2 O-(2-(imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.178 
                 CH 
                 CH 2 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.179 
                 CH 
                 NHCH 2 -(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.180 
                 CH 
                 NHCH 2 -(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.181 
                 CH 
                 NHCH 2 -(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.182 
                 CH 
                 NHCH 2 -(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.183 
                 CH 
                 NHCH 2 -(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.184 
                 CH 
                 CHO 
                 H 
                 CF 3   
                 Me 
               
               
                 3.185 
                 CH 
                 C(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.186 
                 CH 
                 C(O)Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.187 
                 CH 
                 C(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.188 
                 CH 
                 C(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.189 
                 CH 
                 C(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.190 
                 CH 
                 C(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.191 
                 CH 
                 C(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.192 
                 CH 
                 C(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.193 
                 CH 
                 C(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.194 
                 CH 
                 C(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.195 
                 CH 
                 C(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.196 
                 CH 
                 C(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.197 
                 CH 
                 COOH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.198 
                 CH 
                 COOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.199 
                 CH 
                 COOEt 
                 H 
                 CF 3   
                 Me 
               
               
                 3.200 
                 CH 
                 COOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.201 
                 CH 
                 COOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.202 
                 CH 
                 COO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.203 
                 CH 
                 COOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.204 
                 CH 
                 COOPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.205 
                 CH 
                 COO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.206 
                 CH 
                 COO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.207 
                 CH 
                 COO-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.208 
                 CH 
                 COO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.209 
                 CH 
                 COO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.210 
                 CH 
                 CONH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.211 
                 CH 
                 C(O)NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.212 
                 CH 
                 C(O)NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.213 
                 CH 
                 C(O)NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.214 
                 CH 
                 C(O)NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.215 
                 CH 
                 C(O)NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.216 
                 CH 
                 C(O)NHPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.217 
                 CH 
                 C(O)NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.218 
                 CH 
                 C(O)NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.219 
                 CH 
                 C(O)NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.220 
                 CH 
                 C(O)NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.221 
                 CH 
                 C(O)NH-(2-furanyl)) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.222 
                 CH 
                 NHC(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.223 
                 CH 
                 NHC(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.224 
                 CH 
                 NHC(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.225 
                 CH 
                 NHC(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.226 
                 CH 
                 NHC(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.227 
                 CH 
                 NHC(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.228 
                 CH 
                 NHC(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.229 
                 CH 
                 NHC(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.230 
                 CH 
                 NHC(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.231 
                 CH 
                 NHC(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.232 
                 CH 
                 NHC(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.233 
                 CH 
                 NHCOOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.234 
                 CH 
                 NHCOOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.235 
                 CH 
                 NHCOOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.236 
                 CH 
                 NHCOO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.237 
                 CH 
                 NHCOOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.238 
                 CH 
                 NHCOOPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.239 
                 CH 
                 NHCOO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.240 
                 CH 
                 NHCOO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.241 
                 CH 
                 NHCOO-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.242 
                 CH 
                 NHCOO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.243 
                 CH 
                 NHCOO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.244 
                 CH 
                 CN 
                 H 
                 CF 3   
                 Me 
               
               
                 3.245 
                 CH 
                 NO 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.246 
                 CH 
                 Cl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.247 
                 CH 
                 CH 2 CH═CH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.248 
                 CH 
                 CH 2 C≡CH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.249 
                 CH 
                 Me 
                 5-Cl 
                 CF 3   
                 Me 
               
               
                 3.250 
                 CH 
                 Me 
                 5-OMe 
                 CF 3   
                 Me 
               
               
                 3.251 
                 CMe 
                 Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.252 
                 CMe 
                 Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.253 
                 CMe 
                 iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.254 
                 CMe 
                 C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.255 
                 CMe 
                 c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.256 
                 CMe 
                 CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.257 
                 CMe 
                 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.258 
                 CMe 
                 4-Cl-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.259 
                 CMe 
                 2-naphthyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.260 
                 CMe 
                 3-Cl-4-F-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.261 
                 CMe 
                 4-F-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.262 
                 CMe 
                 2-pyridyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.263 
                 CMe 
                 2-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.264 
                 CMe 
                 5-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.265 
                 CMe 
                 2-pyrrolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.266 
                 CMe 
                 2-imidazolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.267 
                 CMe 
                 2-furanyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.268 
                 CMe 
                 OH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.269 
                 CMe 
                 OMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.270 
                 CMe 
                 OiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.271 
                 CMe 
                 OC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.272 
                 CMe 
                 O-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.273 
                 CMe 
                 OCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.274 
                 CMe 
                 OPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.275 
                 CMe 
                 O-(2pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.276 
                 CMe 
                 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.277 
                 CMe 
                 O-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.278 
                 CMe 
                 O-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.279 
                 CMe 
                 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.280 
                 CMe 
                 SH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.281 
                 CMe 
                 SMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.282 
                 CMe 
                 SiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.283 
                 CMe 
                 SC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.284 
                 CMe 
                 S-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.285 
                 CMe 
                 SCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.286 
                 CMe 
                 SPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.287 
                 CMe 
                 NH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.288 
                 CMe 
                 NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.289 
                 CMe 
                 NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.290 
                 CMe 
                 NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.291 
                 CMe 
                 NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.292 
                 CMe 
                 NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.293 
                 CMe 
                 NHPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.294 
                 CMe 
                 NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.295 
                 CMe 
                 NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.296 
                 CMe 
                 NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.297 
                 CMe 
                 NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.298 
                 CMe 
                 NH-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.299 
                 CMe 
                 CH 2 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.300 
                 CMe 
                 CH 2 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.301 
                 CMe 
                 CH 2 O-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.302 
                 CMe 
                 CH 2 O-(2-(imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.303 
                 CMe 
                 CH 2 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.304 
                 CMe 
                 NHCH 2 -(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.305 
                 CMe 
                 NHCH 2 -(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.306 
                 CMe 
                 NHCH 2 -(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.307 
                 CMe 
                 NHCH 2 -(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.308 
                 CMe 
                 NHCH 2 -(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.309 
                 CMe 
                 CHO 
                 H 
                 CF 3   
                 Me 
               
               
                 3.310 
                 CMe 
                 C(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.311 
                 CMe 
                 C(O)Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.312 
                 CMe 
                 C(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.313 
                 CMe 
                 C(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.314 
                 CMe 
                 C(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.315 
                 CMe 
                 C(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.316 
                 CMe 
                 C(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.317 
                 CMe 
                 C(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.318 
                 CMe 
                 C(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.319 
                 CMe 
                 C(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.320 
                 CMe 
                 C(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.321 
                 CMe 
                 C(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.322 
                 CMe 
                 COOH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.323 
                 CMe 
                 COOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.324 
                 CMe 
                 COOEt 
                 H 
                 CF 3   
                 Me 
               
               
                 3.325 
                 CMe 
                 COOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.326 
                 CMe 
                 COOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.327 
                 CMe 
                 COO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.328 
                 CMe 
                 COOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.329 
                 CMe 
                 COOPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.330 
                 CMe 
                 COO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.331 
                 CMe 
                 COO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.332 
                 CMe 
                 COO-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.333 
                 CMe 
                 COO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.334 
                 CMe 
                 COO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.335 
                 CMe 
                 CONH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.336 
                 CMe 
                 C(O)NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.337 
                 CMe 
                 C(O)NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.338 
                 CMe 
                 C(O)NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.339 
                 CMe 
                 C(O)NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.340 
                 CMe 
                 C(O)NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.341 
                 CMe 
                 C(O)NHPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.342 
                 CMe 
                 C(O)NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.343 
                 CMe 
                 C(O)NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.344 
                 CMe 
                 C(O)NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.345 
                 CMe 
                 C(O)NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.346 
                 CMe 
                 C(O)NH-(2-furanyl)) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.347 
                 CMe 
                 NHC(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.348 
                 CMe 
                 NHC(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.349 
                 CMe 
                 NHC(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.350 
                 CMe 
                 NHC(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.351 
                 CMe 
                 NHC(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.352 
                 CMe 
                 NHC(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.353 
                 CMe 
                 NHC(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.354 
                 CMe 
                 NHC(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.355 
                 CMe 
                 NHC(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.356 
                 CMe 
                 NHC(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.357 
                 CMe 
                 NHC(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.358 
                 CMe 
                 NHCOOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.359 
                 CMe 
                 NHCOOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.360 
                 CMe 
                 NHCOOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.361 
                 CMe 
                 NHCOO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.362 
                 CMe 
                 NHCOOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.363 
                 CMe 
                 NHCOOPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.364 
                 CMe 
                 NHCOO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.365 
                 CMe 
                 NHCOO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.366 
                 CMe 
                 NHCOO-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.367 
                 CMe 
                 NHCOO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.368 
                 CMe 
                 NHCOO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.369 
                 CMe 
                 CN 
                 H 
                 CF 3   
                 Me 
               
               
                 3.370 
                 CMe 
                 NO 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.371 
                 CMe 
                 Cl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.372 
                 CMe 
                 CH 2 CH═CH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.373 
                 CMe 
                 CH 2 C≡CH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.374 
                 CMe 
                 Me 
                 5-Cl 
                 CF 3   
                 Me 
               
               
                 3.375 
                 CMe 
                 Me 
                 5-OMe 
                 CF 3   
                 Me 
               
               
                 3.376 
                 CF 
                 Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.377 
                 CF 
                 Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.378 
                 CF 
                 iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.379 
                 CF 
                 C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.380 
                 CF 
                 c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.381 
                 CF 
                 CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.382 
                 CF 
                 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.383 
                 CF 
                 4-Cl-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.384 
                 CF 
                 2-naphthyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.385 
                 CF 
                 3-Cl-4-F-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.386 
                 CF 
                 4-F-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.387 
                 CF 
                 2-pyridyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.388 
                 CF 
                 2-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.389 
                 CF 
                 5-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.390 
                 CF 
                 2-pyrrolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.391 
                 CF 
                 2-imidazolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.392 
                 CF 
                 2-furanyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.393 
                 CF 
                 OH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.394 
                 CF 
                 OMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.395 
                 CF 
                 OiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.396 
                 CF 
                 OC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.397 
                 CF 
                 O-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.398 
                 CF 
                 OCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.399 
                 CF 
                 OPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.400 
                 CF 
                 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.401 
                 CF 
                 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.402 
                 CF 
                 O-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.403 
                 CF 
                 P-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.404 
                 CF 
                 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.405 
                 CF 
                 SH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.406 
                 CF 
                 SMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.407 
                 CF 
                 SiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.408 
                 CF 
                 SC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.409 
                 CF 
                 S-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.410 
                 CF 
                 SCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.411 
                 CF 
                 SPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.412 
                 CF 
                 NH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.413 
                 CF 
                 NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.414 
                 CF 
                 NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.415 
                 CF 
                 NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.416 
                 CF 
                 NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.417 
                 CF 
                 NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.418 
                 CF 
                 NHPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.419 
                 CF 
                 NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.420 
                 CF 
                 NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.421 
                 CF 
                 NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.422 
                 CF 
                 NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.423 
                 CF 
                 NH-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.424 
                 CF 
                 CH 2 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.425 
                 CF 
                 CH 2 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.426 
                 CF 
                 CH 2 O-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.427 
                 CF 
                 CH 2 O-(2-(imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.428 
                 CF 
                 CH 2 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.429 
                 CF 
                 NHCH 2 -(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.430 
                 CF 
                 NHCH 2 -(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.431 
                 CF 
                 NHCH 2 -(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.432 
                 CF 
                 NHCH 2 -(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.433 
                 CF 
                 NHCH 2 -(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.434 
                 CF 
                 CHO 
                 H 
                 CF 3   
                 Me 
               
               
                 3.435 
                 CF 
                 C(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.436 
                 CF 
                 C(O)Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.437 
                 CF 
                 C(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.438 
                 CF 
                 C(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.439 
                 CF 
                 C(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.440 
                 CF 
                 C(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.441 
                 CF 
                 C(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.442 
                 CF 
                 C(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.443 
                 CF 
                 C(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.444 
                 CF 
                 C(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.445 
                 CF 
                 C(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.446 
                 CF 
                 C(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.447 
                 CF 
                 COOH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.448 
                 CF 
                 COOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.449 
                 CF 
                 COOEt 
                 H 
                 CF 3   
                 Me 
               
               
                 3.450 
                 CF 
                 COOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.451 
                 CF 
                 COOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.452 
                 CF 
                 COO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.453 
                 CF 
                 COOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.544 
                 CF 
                 COOPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.455 
                 CF 
                 COO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.456 
                 CF 
                 COO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.457 
                 CF 
                 COO-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.458 
                 CF 
                 COO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.459 
                 CF 
                 COO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.460 
                 CF 
                 CONH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.461 
                 CF 
                 C(O)NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.462 
                 CF 
                 C(O)NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.463 
                 CF 
                 C(O)NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.464 
                 CF 
                 C(O)NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.465 
                 CF 
                 C(O)NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.466 
                 CF 
                 C(O)NHPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.467 
                 CF 
                 C(O)NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.468 
                 CF 
                 C(O)NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.469 
                 CF 
                 C(O)NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.470 
                 CF 
                 C(O)NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.471 
                 CF 
                 C(O)NH-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.472 
                 CF 
                 NHC(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.473 
                 CF 
                 NHC(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.474 
                 CF 
                 NHC(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.475 
                 CF 
                 NHC(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.476 
                 CF 
                 NHC(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.477 
                 CF 
                 NHC(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.478 
                 CF 
                 NHC(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.479 
                 CF 
                 NHC(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.480 
                 CF 
                 NHC(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.481 
                 CF 
                 NHC(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.482 
                 CF 
                 NHC(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.483 
                 CF 
                 NHCOOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.484 
                 CF 
                 NHCOOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.485 
                 CF 
                 NHCOOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.486 
                 CF 
                 NHCOO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.487 
                 CF 
                 NHCOOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.488 
                 CF 
                 NHCOOPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.489 
                 CF 
                 NHCOO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.490 
                 CF 
                 NHCOO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.491 
                 CF 
                 NHCOO-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.492 
                 CF 
                 NHCOO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.493 
                 CF 
                 NHCOO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.494 
                 CF 
                 CN 
                 H 
                 CF 3   
                 Me 
               
               
                 3.495 
                 CF 
                 NO 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.496 
                 CF 
                 Cl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.497 
                 CF 
                 CH 2 CH═CH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.498 
                 CF 
                 CH 2 C≡CH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.499 
                 CF 
                 Me 
                 5-Cl 
                 CF 3   
                 Me 
               
               
                 3.500 
                 CF 
                 Me 
                 5-OMe 
                 CF 3   
                 Me 
               
               
                 3.501 
                 CBr 
                 Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.502 
                 CBr 
                 Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.503 
                 CBr 
                 iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.504 
                 CBr 
                 C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.505 
                 CBr 
                 c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.506 
                 CBr 
                 CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.507 
                 CBr 
                 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.508 
                 CBr 
                 4-Cl-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.509 
                 CBr 
                 2-naphthyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.510 
                 CBr 
                 3-Cl-4-F-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.511 
                 CBr 
                 4-F-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.512 
                 CBr 
                 2-pyridyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.513 
                 CBr 
                 2-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.514 
                 CBr 
                 5-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.515 
                 CBr 
                 2-pyrrolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.516 
                 CBr 
                 2-imidazolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.517 
                 CBr 
                 2-furanyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.518 
                 CBr 
                 OH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.519 
                 CBr 
                 OMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.520 
                 CBr 
                 OiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.521 
                 CBr 
                 OC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.522 
                 CBr 
                 O-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.523 
                 CBr 
                 OCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.524 
                 CBr 
                 OPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.525 
                 CBr 
                 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.526 
                 CBr 
                 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.527 
                 CBr 
                 O-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.528 
                 CBr 
                 O-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.529 
                 CBr 
                 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.530 
                 CBr 
                 SH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.531 
                 CBr 
                 SMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.532 
                 CBr 
                 SiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.533 
                 CBr 
                 SC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.534 
                 CBr 
                 S-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.535 
                 CBr 
                 SCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.536 
                 CBr 
                 SPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.537 
                 CBr 
                 NH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.538 
                 CBr 
                 NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.539 
                 CBr 
                 NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.540 
                 CBr 
                 NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.541 
                 CBr 
                 NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.542 
                 CBr 
                 NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.543 
                 CBr 
                 NHPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.544 
                 CBr 
                 NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.545 
                 CBr 
                 NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.546 
                 CBr 
                 NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.547 
                 CBr 
                 NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.548 
                 CBr 
                 NH-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.549 
                 CBr 
                 CH 2 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.550 
                 CBr 
                 CH 2 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.551 
                 Cbr 
                 CH 2 O-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.552 
                 CBr 
                 CH 2 O-(2-(imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.553 
                 CBr 
                 CH 2 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.554 
                 CBr 
                 NHCH 2 -(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.555 
                 CBr 
                 NHCH 2 -(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.556 
                 CBr 
                 NHCH 2 -(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.557 
                 CBr 
                 NHCH 2 -(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.558 
                 CBr 
                 NHCH 2 -(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.559 
                 CBr 
                 CHO 
                 H 
                 CF 3   
                 Me 
               
               
                 3.560 
                 CBr 
                 C(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.561 
                 CBr 
                 C(O)Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.562 
                 CBr 
                 C(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.563 
                 CBr 
                 C(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.564 
                 CBr 
                 C(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.565 
                 CBr 
                 C(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.566 
                 CBr 
                 C(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.567 
                 CBr 
                 C(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.568 
                 CBr 
                 C(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.569 
                 Cbr 
                 C(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.570 
                 CBr 
                 C(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.571 
                 CBr 
                 C(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.572 
                 CBr 
                 COOH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.573 
                 CBr 
                 COOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.574 
                 CBr 
                 COOEt 
                 H 
                 CF 3   
                 Me 
               
               
                 3.575 
                 CBr 
                 COOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.576 
                 CBr 
                 COOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.577 
                 CBr 
                 COO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.578 
                 CBr 
                 COOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.579 
                 CBr 
                 COOPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.580 
                 CBr 
                 COO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.581 
                 CBr 
                 COO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.582 
                 CBr 
                 COO-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.583 
                 CBr 
                 COO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.584 
                 CBr 
                 COO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.585 
                 CBr 
                 CONH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.586 
                 CBr 
                 C(O)NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.587 
                 CBr 
                 C(O)NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.588 
                 CBr 
                 C(O)NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.589 
                 CBr 
                 C(O)NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.590 
                 CBr 
                 C(O)NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.591 
                 CBr 
                 C(O)NHPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.592 
                 CBr 
                 C(O)NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.593 
                 CBr 
                 C(O)NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.594 
                 CBr 
                 C(O)NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.595 
                 CBr 
                 C(O)NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.596 
                 CBr 
                 C(O)NH-(2-furanyl)) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.597 
                 CBr 
                 NHC(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.598 
                 CBr 
                 NHC(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.599 
                 CBr 
                 NHC(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.600 
                 CBr 
                 NHC(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.601 
                 CBr 
                 NHC(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.602 
                 CBr 
                 NHC(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.603 
                 CBr 
                 NHC(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.604 
                 CBr 
                 NHC(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.605 
                 CBr 
                 NHC(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.606 
                 CBr 
                 NHC(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.607 
                 CBr 
                 NHC(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.608 
                 CBr 
                 NHCOOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.609 
                 CBr 
                 HCOOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.610 
                 CBr 
                 NHCOOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.611 
                 CBr 
                 NHCOO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.612 
                 Cbr 
                 NHCOOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.613 
                 CBr 
                 NHCOOPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.614 
                 CBr 
                 NHCOO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.615 
                 Cbr 
                 NHCOO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.616 
                 CBr 
                 NHCOO-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.617 
                 CBr 
                 NHCOO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.618 
                 CBr 
                 NHCOO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.619 
                 CBr 
                 CN 
                 H 
                 CF 3   
                 Me 
               
               
                 3.620 
                 CBr 
                 NO 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.621 
                 CBr 
                 Cl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.622 
                 CBr 
                 CH 2 CH═CH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.623 
                 CBr 
                 CH 2 C≡CH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.624 
                 CBr 
                 Me 
                 5-Cl 
                 CF 3   
                 Me 
               
               
                 3.625 
                 CBr 
                 Me 
                 5-OMe 
                 CF 3   
                 Me 
               
               
                 3.626 
                 CCN 
                 Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.627 
                 CCN 
                 Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.628 
                 CCN 
                 iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.629 
                 CCN 
                 C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.630 
                 CCN 
                 c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.631 
                 CCN 
                 CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.632 
                 CCN 
                 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.633 
                 CCN 
                 4-Cl-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.634 
                 CCN 
                 2-naphthyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.635 
                 CCN 
                 3-Cl-4-F-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.636 
                 CCN 
                 4-F-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.637 
                 CCN 
                 2-pyridyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.638 
                 CCN 
                 2-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.639 
                 CCN 
                 5-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.640 
                 CCN 
                 2-pyrrolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.641 
                 CCN 
                 2-imidazolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.642 
                 CCN 
                 2-furanyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.643 
                 CCN 
                 OH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.644 
                 CCN 
                 OMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.645 
                 CCN 
                 OiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.646 
                 CCN 
                 OC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.647 
                 CCN 
                 O-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.648 
                 CCN 
                 OCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.649 
                 CCN 
                 OPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.650 
                 CCN 
                 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.651 
                 CCN 
                 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.652 
                 CCN 
                 O-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.653 
                 CCN 
                 O-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.654 
                 CCN 
                 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.655 
                 CCN 
                 SH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.656 
                 CCN 
                 SMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.657 
                 CCN 
                 SiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.658 
                 CCN 
                 SC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.659 
                 CCN 
                 S-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.660 
                 CCN 
                 SCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.661 
                 CCN 
                 SPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.662 
                 CCN 
                 NH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.663 
                 CCN 
                 NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.664 
                 CCN 
                 NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.665 
                 CCN 
                 NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.666 
                 CCN 
                 NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.667 
                 CCN 
                 NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.668 
                 CCN 
                 NHPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.669 
                 CCN 
                 NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.670 
                 CCN 
                 NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.671 
                 CCN 
                 NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.672 
                 CCN 
                 NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.673 
                 CCN 
                 NH-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.674 
                 CCN 
                 CH 2 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.675 
                 CCN 
                 CH 2 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.676 
                 CCN 
                 CH 2 O-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.677 
                 CCN 
                 CH 2 O-(2-(imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.678 
                 CCN 
                 CH 2 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.679 
                 CCN 
                 NHCH 2 -(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.680 
                 CCN 
                 NHCH 2 -(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.681 
                 CCN 
                 NHCH 2 -(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.682 
                 CCN 
                 NHCH 2 -(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.683 
                 CCN 
                 NHCH 2 -(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.684 
                 CCN 
                 CHO 
                 H 
                 CF 3   
                 Me 
               
               
                 3.685 
                 CCN 
                 C(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.686 
                 CCN 
                 C(O)Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.687 
                 CCN 
                 C(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.688 
                 CCN 
                 C(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.689 
                 CCN 
                 C(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.690 
                 CCN 
                 C(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.691 
                 CCN 
                 C(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.692 
                 CCN 
                 C(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.693 
                 CCN 
                 C(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.694 
                 CCN 
                 C(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.695 
                 CCN 
                 C(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.696 
                 CCN 
                 C(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.697 
                 CCN 
                 COOH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.698 
                 CCN 
                 COOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.699 
                 CCN 
                 COOEt 
                 H 
                 CF 3   
                 Me 
               
               
                 3.700 
                 CCN 
                 COOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.701 
                 CCN 
                 COOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.702 
                 CCN 
                 COO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.703 
                 CCN 
                 COOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.704 
                 CCN 
                 COOPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.705 
                 CCN 
                 COO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.706 
                 CCN 
                 COO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.707 
                 CCN 
                 COO-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.708 
                 CCN 
                 COO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.709 
                 CCN 
                 COO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.710 
                 CCN 
                 CONH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.711 
                 CCN 
                 C(O)NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.712 
                 CCN 
                 C(O)NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.713 
                 CCN 
                 C(O)NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.714 
                 CCN 
                 C(O)NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.715 
                 CCN 
                 C(O)NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.716 
                 CCN 
                 C(O)NHPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.717 
                 CCN 
                 C(O)NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.718 
                 CCN 
                 C(O)NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.719 
                 CCN 
                 C(O)NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.720 
                 CCN 
                 C(O)NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.721 
                 CCN 
                 C(O)NH-(2-furanyl)) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.722 
                 CCN 
                 NHC(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.723 
                 CCN 
                 NHC(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.724 
                 CCN 
                 NHC(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.725 
                 CCN 
                 NHC(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.726 
                 CCN 
                 NHC(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.727 
                 CCN 
                 NHC(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.728 
                 CCN 
                 NHC(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.729 
                 CCN 
                 NHC(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.730 
                 CCN 
                 NHC(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.731 
                 CCN 
                 NHC(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.732 
                 CCN 
                 NHC(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.733 
                 CCN 
                 NHCOOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.734 
                 CCN 
                 NHCOOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.735 
                 CCN 
                 NHCOOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.736 
                 CCN 
                 NHCOO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.737 
                 CCN 
                 NHCOOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.738 
                 CCN 
                 NHCOOPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.739 
                 CCN 
                 NHCOO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.740 
                 CCN 
                 NHCOO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.741 
                 CCN 
                 NHCOO-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.742 
                 CCN 
                 NHCOO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.743 
                 CCN 
                 NHCOO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.744 
                 CCN 
                 CN 
                 H 
                 CF 3   
                 Me 
               
               
                 3.745 
                 CCN 
                 NO 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.746 
                 CCN 
                 Cl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.747 
                 CCN 
                 CH 2 CH═CH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.748 
                 CCN 
                 CH 2 C≡CH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.749 
                 CCN 
                 Me 
                 5-Cl 
                 CF 3   
                 Me 
               
               
                 3.750 
                 CCN 
                 Me 
                 5-OMe 
                 CF 3   
                 Me 
               
               
                 3.751 
                 CNO 2   
                 Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.752 
                 CNO 2   
                 Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.753 
                 CNO 2   
                 iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.754 
                 CNO 2   
                 C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.755 
                 CNO 2   
                 c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.756 
                 CNO 2   
                 CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.757 
                 CNO 2   
                 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.758 
                 CNO 2   
                 4-Cl-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.759 
                 CNO 2   
                 2-naphthyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.760 
                 CNO 2   
                 3-Cl-4-F-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.761 
                 CNO 2   
                 4-F-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.762 
                 CNO 2   
                 2-pyridyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.763 
                 CNO 2   
                 2-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.764 
                 CNO 2   
                 5-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.765 
                 CNO 2   
                 2-pyrrolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.766 
                 CNO 2   
                 2-imidazolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.767 
                 CNO 2   
                 2-furanyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.768 
                 CNO 2   
                 OH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.769 
                 CNO 2   
                 OMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.770 
                 CNO 2   
                 OiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.771 
                 CNO 2   
                 OC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.772 
                 CNO 2   
                 O-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.773 
                 CNO 2   
                 OCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.774 
                 CNO 2   
                 OPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.775 
                 CNO 2   
                 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.776 
                 CNO 2   
                 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.777 
                 CNO 2   
                 O-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.778 
                 CNO 2   
                 O-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.779 
                 CNO 2   
                 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.780 
                 CNO 2   
                 SH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.781 
                 CNO 2   
                 SMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.782 
                 CNO 2   
                 SiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.783 
                 CNO 2   
                 SC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.784 
                 CNO 2   
                 S-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.785 
                 CNO 2   
                 SCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.786 
                 CNO 2   
                 SPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.787 
                 CNO 2   
                 NH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.788 
                 CNO 2   
                 NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.789 
                 CNO 2   
                 NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.790 
                 CNO 2   
                 NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.791 
                 CNO 2   
                 NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.792 
                 CNO 2   
                 NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.793 
                 CNO 2   
                 NHPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.794 
                 CNO 2   
                 NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.795 
                 CNO 2   
                 NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.796 
                 CNO 2   
                 NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.797 
                 CNO 2   
                 NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.798 
                 CNO 2   
                 NH-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.799 
                 CNO 2   
                 CH 2 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.800 
                 CNO 2   
                 CH 2 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.801 
                 CNO 2   
                 CH 2 O-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.802 
                 CNO 2   
                 CH 2 O-(2-(imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.803 
                 CNO 2   
                 CH 2 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.804 
                 CNO 2   
                 NHCH 2 -(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.805 
                 CNO 2   
                 NHCH 2 -(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.806 
                 CNO 2   
                 NHCH 2 -(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.807 
                 CNO 2   
                 NHCH 2 -(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.808 
                 CNO 2   
                 NHCH 2 -(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.809 
                 CNO 2   
                 CHO 
                 H 
                 CF 3   
                 Me 
               
               
                 3.810 
                 CNO 2   
                 C(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.811 
                 CNO 2   
                 C(O)Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.812 
                 CNO 2   
                 C(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.813 
                 CNO 2   
                 C(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.814 
                 CNO 2   
                 C(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.815 
                 CNO 2   
                 C(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.816 
                 CNO 2   
                 C(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.817 
                 CNO 2   
                 C(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.818 
                 CNO 2   
                 C(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.819 
                 CNO 2   
                 C(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.820 
                 CNO 2   
                 C(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.821 
                 CNO 2   
                 C(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.822 
                 CNO 2   
                 COOH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.823 
                 CNO 2   
                 COOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.824 
                 CNO 2   
                 COOEt 
                 H 
                 CF 3   
                 Me 
               
               
                 3.825 
                 CNO 2   
                 COOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.826 
                 CNO 2   
                 COOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.827 
                 CNO 2   
                 COO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.828 
                 CNO 2   
                 COOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.829 
                 CNO 2   
                 COOPPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.830 
                 CNO 2   
                 COO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.831 
                 CNO 2   
                 COO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.832 
                 CNO 2   
                 COO-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.833 
                 CNO 2   
                 COO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.834 
                 CNO 2   
                 COO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.835 
                 CNO 2   
                 CONH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.836 
                 CNO 2   
                 C(O)NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.837 
                 CNO 2   
                 C(O)NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.838 
                 CNO 2   
                 C(O)NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.839 
                 CNO 2   
                 C(O)NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.840 
                 CNO 2   
                 C(O)NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.841 
                 CNO 2   
                 C(O)NHPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.842 
                 CNO 2   
                 C(O)NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.843 
                 CNO 2   
                 C(O)NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.844 
                 CNO 2   
                 C(O)NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.845 
                 CNO 2   
                 C(O)NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.846 
                 CNO 2   
                 C(O)NH-(2-furanyl)) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.847 
                 CNO 2   
                 NHC(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.848 
                 CNO 2   
                 NHC(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.849 
                 CNO 2   
                 NHC(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.850 
                 CNO 2   
                 NHC(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.851 
                 CNO 2   
                 NHC(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.852 
                 CNO 2   
                 NHC(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.853 
                 CNO 2   
                 NHC(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.854 
                 CNO 2   
                 NHC(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.855 
                 CNO 2   
                 NHC(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.856 
                 CNO 2   
                 NHC(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.857 
                 CNO 2   
                 NHC(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.858 
                 CNO 2   
                 NHCOOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.859 
                 CNO 2   
                 NHCOOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.860 
                 CNO 2   
                 NHCOOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.861 
                 CNO 2   
                 NHCOO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.862 
                 CNO 2   
                 NHCOOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.863 
                 CNO 2   
                 NHCOOPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.864 
                 CNO 2   
                 NHCOO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.865 
                 CNO 2   
                 NHCOO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.866 
                 CNO 2   
                 NHCOO-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.867 
                 CNO 2   
                 NHCOO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.868 
                 CNO 2   
                 NHCO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.869 
                 CNO 2   
                 CN 
                 H 
                 CF 3   
                 Me 
               
               
                 3.870 
                 CNO 2   
                 NO 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.871 
                 CNO 2   
                 Cl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.872 
                 CNO 2   
                 CH 2 CH═CH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.873 
                 CNO 2   
                 CH 2 C≡CH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.874 
                 CNO 2   
                 Me 
                 5-Cl 
                 CF 3   
                 Me 
               
               
                 3.875 
                 CNO 2   
                 Me 
                 5-OMe 
                 CF 3   
                 Me 
               
               
                 3.876 
                 C-c-C 3 H 5   
                 Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.877 
                 C-c-C 3 H 5   
                 Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.878 
                 C-c-C 3 H 5   
                 iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.879 
                 C-c-C 3 H 5   
                 C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.880 
                 C-c-C 3 H 5   
                 c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.881 
                 C-c-C 3 H 5   
                 CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.882 
                 C-c-C 3 H 5   
                 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.883 
                 C-c-C 3 H 5   
                 4-Cl-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.884 
                 C-c-C 3 H 5   
                 2-naphthyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.885 
                 C-c-C 3 H 5   
                 3-Cl-4-F-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.886 
                 C-c-C 3 H 5   
                 4-F-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.887 
                 C-c-C 3 H 5   
                 2-pyridyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.888 
                 C-c-C 3 H 5   
                 2-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.889 
                 C-c-C 3 H 5   
                 5-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.890 
                 C-c-C 3 H 5   
                 2-pyrrolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.891 
                 C-c-C 3 H 5   
                 2-imidazolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.892 
                 C-c-C 3 H 5   
                 2-furanyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.893 
                 C-c-C 3 H 5   
                 OH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.894 
                 C-c-C 3 H 5   
                 OMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.895 
                 C-c-C 3 H 5   
                 OiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.896 
                 C-c-C 3 H 5   
                 OC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.897 
                 C-c-C 3 H 5   
                 O-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.898 
                 C-c-C 3 H 5   
                 OCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.899 
                 C-c-C 3 H 5   
                 OPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.900 
                 C-c-C 3 H 5   
                 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.901 
                 C-c-C 3 H 5   
                 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.902 
                 C-c-C 3 H 5   
                 O-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.903 
                 C-c-C 3 H 5   
                 O-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.904 
                 C-c-C 3 H 5   
                 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.905 
                 C-c-C 3 H 5   
                 SH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.906 
                 C-c-C 3 H 5   
                 SMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.907 
                 C-c-C 3 H 5   
                 SiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.908 
                 C-c-C 3 H 5   
                 SC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.909 
                 C-c-C 3 H 5   
                 S-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.910 
                 C-c-C 3 H 5   
                 SCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.911 
                 C-c-C 3 H 5   
                 SPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.912 
                 C-c-C 3 H 5   
                 NH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.913 
                 C-c-C 3 H 5   
                 NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.914 
                 C-c-C 3 H 5   
                 NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.915 
                 C-c-C 3 H 5   
                 NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.916 
                 C-c-C 3 H 5   
                 NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.917 
                 C-c-C 3 H 5   
                 NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.918 
                 C-c-C 3 H 5   
                 HPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.919 
                 C-c-C 3 H 5   
                 NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.920 
                 C-c-C 3 H 5   
                 NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.921 
                 C-c-C 3 H 5   
                 NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.922 
                 C-c-C 3 H 5   
                 NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.923 
                 C-c-C 3 H 5   
                 NH-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.924 
                 C-c-C 3 H 5   
                 CH 2 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.925 
                 C-c-C 3 H 5   
                 CH 2 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.926 
                 C-c-C 3 H 5   
                 CH 2 O-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.927 
                 C-c-C 3 H 5   
                 CH 2 O-(2-(imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.928 
                 C-c-C 3 H 5   
                 CH 2 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.929 
                 C-c-C 3 H 5   
                 NHCH 2 -(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.930 
                 C-c-C 3 H 5   
                 NHCH 2 -(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.931 
                 C-c-C 3 H 5   
                 NHCH 2 -(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.932 
                 C-c-C 3 H 5   
                 NHCH 2 -(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.933 
                 C-c-C 3 H 5   
                 NHCH 2 -(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.934 
                 C-c-C 3 H 5   
                 CHO 
                 H 
                 CF 3   
                 Me 
               
               
                 3.935 
                 C-c-C 3 H 5   
                 C(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.936 
                 C-c-C 3 H 5   
                 C(O)Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.937 
                 C-c-C 3 H 5   
                 C(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.938 
                 C-c-C 3 H 5   
                 C(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.939 
                 C-c-C 3 H 5   
                 C(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.940 
                 C-c-C 3 H 5   
                 C(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.941 
                 C-c-C 3 H 5   
                 C(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.942 
                 C-c-C 3 H 5   
                 C(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.943 
                 C-c-C 3 H 5   
                 C(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.944 
                 C-c-C 3 H 5   
                 C(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.945 
                 C-c-C 3 H 5   
                 C(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.946 
                 C-c-C 3 H 5   
                 C(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.947 
                 C-c-C 3 H 5   
                 COOH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.948 
                 C-c-C 3 H 5   
                 COOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.949 
                 C-c-C 3 H 5   
                 COOEt 
                 H 
                 CF 3   
                 Me 
               
               
                 3.950 
                 C-c-C 3 H 5   
                 COOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.951 
                 C-c-C 3 H 5   
                 COOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.952 
                 C-c-C 3 H 5   
                 COO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.953 
                 C-c-C 3 H 5   
                 COOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.954 
                 C-c-C 3 H 5   
                 COOPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.955 
                 C-c-C 3 H 5   
                 COO-(2pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.956 
                 C-c-C 3 H 5   
                 COO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.957 
                 C-c-C 3 H 5   
                 COO-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.958 
                 C-c-C 3 H 5   
                 COO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.959 
                 C-c-C 3 H 5   
                 COO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.960 
                 C-c-C 3 H 5   
                 CONH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.961 
                 C-c-C 3 H 5   
                 C(O)NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.962 
                 C-c-C 3 H 5   
                 C(O)NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.963 
                 C-c-C 3 H 5   
                 C(O)NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.964 
                 C-c-C 3 H 5   
                 C(O)NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.965 
                 C-c-C 3 H 5   
                 C(O)NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.966 
                 C-c-C 3 H 5   
                 C(O)NHPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.967 
                 C-c-C 3 H 5   
                 C(O)NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.968 
                 C-c-C 3 H 5   
                 C(O)NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.969 
                 C-c-C 3 H 5   
                 C(O)NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.970 
                 C-c-C 3 H 5   
                 C(O)NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.971 
                 C-c-C 3 H 5   
                 C(O)NH-(2-furanyl)) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.972 
                 C-c-C 3 H 5   
                 NHC(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.973 
                 C-c-C 3 H 5   
                 NHC(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.974 
                 C-c-C 3 H 5   
                 NHC(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.975 
                 C-c-C 3 H 5   
                 NHC(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.976 
                 C-c-C 3 H 5   
                 NHC(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.977 
                 C-c-C 3 H 5   
                 NHC(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.978 
                 C-c-C 3 H 5   
                 NHC(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.979 
                 C-c-C 3 H 5   
                 NHC(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.980 
                 C-c-C 3 H 5   
                 NHC(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.981 
                 C-c-C 3 H 5   
                 NHC(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.982 
                 C-c-C 3 H 5   
                 NHC(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.983 
                 C-c-C 3 H 5   
                 NHCOOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.984 
                 C-c-C 3 H 5   
                 NHCOOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.985 
                 C-c-C 3 H 5   
                 NHCOOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.986 
                 C-c-C 3 H 5   
                 NHCOO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.987 
                 C-c-C 3 H 5   
                 NHCOOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.988 
                 C-c-C 3 H 5   
                 NHCOOPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.989 
                 C-c-C 3 H 5   
                 NHCOO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.990 
                 C-c-C 3 H 5   
                 NHCOO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.991 
                 C-c-C 3 H 5   
                 NHCOO-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.992 
                 C-c-C 3 H 5   
                 NHCOO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.993 
                 C-c-C 3 H 5   
                 NHCOO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.994 
                 C-c-C 3 H 5   
                 CN 
                 H 
                 CF 3   
                 Me 
               
               
                 3.995 
                 C-c-C 3 H 5   
                 NO 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.996 
                 C-c-C 3 H 5   
                 Cl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.997 
                 C-c-C 3 H 5   
                 CH 2 CH═CH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.998 
                 C-c-C 3 H 5   
                 CH 2 C≡CH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.999 
                 C-c-C 3 H 5   
                 Me 
                 5-Cl 
                 CF 3   
                 Me 
               
               
                 3.1000 
                 C-c-C 3 H 7   
                 Me 
                 5-OMe 
                 CF 3   
                 Me 
               
               
                 3.1001 
                 N 
                 Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1002 
                 N 
                 Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1003 
                 N 
                 iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1004 
                 N 
                 C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1005 
                 N 
                 c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1006 
                 N 
                 CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1007 
                 N 
                 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1008 
                 N 
                 4-Cl-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1009 
                 N 
                 2-naphthyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1010 
                 N 
                 3-Cl-4-F-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1011 
                 N 
                 4-F-Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1012 
                 N 
                 2-pyridyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1013 
                 N 
                 2-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1014 
                 N 
                 5-pyrimidinyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1015 
                 N 
                 2-pyrrolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1016 
                 N 
                 2-imidazolyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1017 
                 N 
                 2-furanyl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1018 
                 N 
                 OH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1019 
                 N 
                 OMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1020 
                 N 
                 OiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1021 
                 N 
                 OC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1022 
                 N 
                 O-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1023 
                 N 
                 OCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1024 
                 N 
                 OPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1025 
                 N 
                 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1026 
                 N 
                 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1027 
                 N 
                 O-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1028 
                 N 
                 O-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1029 
                 N 
                 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1030 
                 N 
                 SH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1031 
                 N 
                 SMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1032 
                 N 
                 SiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1033 
                 N 
                 SC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1034 
                 N 
                 S-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1035 
                 N 
                 SCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1036 
                 N 
                 SPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1037 
                 N 
                 NH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1038 
                 N 
                 NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1039 
                 N 
                 NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1040 
                 N 
                 NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1041 
                 N 
                 NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1042 
                 N 
                 NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1043 
                 N 
                 NHPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1044 
                 N 
                 NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1045 
                 N 
                 NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1046 
                 N 
                 NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1047 
                 N 
                 NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1048 
                 N 
                 NH-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1049 
                 N 
                 CH 2 O-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1050 
                 N 
                 CH 2 O-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1051 
                 N 
                 CH 2 O-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1052 
                 N 
                 CH 2 O-(2-(imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1053 
                 N 
                 CH 2 O-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1054 
                 N 
                 NHCH 2 -(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1055 
                 N 
                 NHCH 2 -(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1056 
                 N 
                 NHCH 2 -(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1057 
                 N 
                 NHCH 2 -(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1058 
                 N 
                 NHCH 2 -(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1059 
                 N 
                 CHO 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1060 
                 N 
                 C(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1061 
                 N 
                 C(O)Et 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1062 
                 N 
                 C(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1063 
                 N 
                 C(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1064 
                 N 
                 C(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1065 
                 N 
                 C(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1066 
                 N 
                 C(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1067 
                 N 
                 C(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1068 
                 N 
                 C(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1069 
                 N 
                 C(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1070 
                 N 
                 C(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1071 
                 N 
                 C(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1072 
                 N 
                 COOH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1073 
                 N 
                 COOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1074 
                 N 
                 COOEt 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1075 
                 N 
                 COOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1076 
                 N 
                 COOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1077 
                 N 
                 COO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1078 
                 N 
                 COOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1079 
                 N 
                 COOPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1080 
                 N 
                 COO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1081 
                 N 
                 COO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1082 
                 N 
                 COO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1083 
                 N 
                 COO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1084 
                 N 
                 COO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1085 
                 N 
                 CONH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1086 
                 N 
                 C(O)NHMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1087 
                 N 
                 C(O)NHiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1088 
                 N 
                 C(O)NHC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1089 
                 N 
                 C(O)NH-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1090 
                 N 
                 C(O)NHCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1091 
                 N 
                 C(O)NHPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1092 
                 N 
                 C(O)NH-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1093 
                 N 
                 C(O)NH-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1094 
                 N 
                 C(O)NH-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1095 
                 N 
                 C(O)NH-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1096 
                 N 
                 C(O)NH-(2-furanyl)) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1097 
                 N 
                 NHC(O)Me 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1098 
                 N 
                 NHC(O)iPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1099 
                 N 
                 NHC(O)C 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1100 
                 N 
                 NHC(O)-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1101 
                 N 
                 NHC(O)CH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1102 
                 N 
                 NHC(O)Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1103 
                 N 
                 NHC(O)-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1104 
                 N 
                 NHC(O)-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1105 
                 N 
                 NHC(O)-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1106 
                 N 
                 NHC(O)-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1107 
                 N 
                 NHC(O)-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1108 
                 N 
                 NHCOOMe 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1109 
                 N 
                 NHCOOiPr 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1110 
                 N 
                 NHCOOC 6 H 12   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1111 
                 N 
                 NHCOO-c-C 3 H 5   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1112 
                 N 
                 NHCOOCH 2 Ph 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1113 
                 N 
                 NHCOOPh 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1114 
                 N 
                 NHCOO-(2-pyridyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1115 
                 N 
                 NHCOO-(2-pyrimidinyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1116 
                 N 
                 NHCOO-(2-pyrrolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1117 
                 N 
                 NHCOO-(2-imidazolyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1118 
                 N 
                 NHCOO-(2-furanyl) 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1119 
                 N 
                 CN 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1120 
                 N 
                 NO 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1121 
                 N 
                 Cl 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1122 
                 N 
                 CH 2 CH═CH 2   
                 H 
                 CF 3   
                 Me 
               
               
                 3.1123 
                 N 
                 CH 2 C≡CH 
                 H 
                 CF 3   
                 Me 
               
               
                 3.1124 
                 N 
                 Me 
                 5-Cl 
                 CF 3   
                 Me 
               
               
                 3.1125 
                 N 
                 Me 
                 5-OMe 
                 CF 3   
                 Me 
               
               
                 3.1126 
                 CCl 
                 CH 2 OH 
                 H 
                 CF 3   
                 Me 
                 69-71 
               
               
                 3.1127 
                 CCl 
                 CH 2 OCH 2 CH 3   
                 H 
                 CF 3   
                 Me 
                 oil 
               
               
                 3.1128 
                 CCl 
                 CH 2 CN 
                 H 
                 CF 3   
                 Me 
                 69-72 
               
               
                 3.1129 
                 CCl 
                 CH 2 SCH 3   
                 H 
                 CF 3   
                 Me 
                 111-114 
               
               
                   
               
               
                 3.1130 
                 CCl 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 H 
                 CF 3   
                 Me 
                 oil 
               
               
                   
               
               
                 3.1131 
                 CCl 
                 CH 2 NHCH 3   
                 H 
                 CF 3   
                 Me 
                 oil 
               
               
                 3.1132 
                 CCl 
                 CH 2 N(CH 3 ) 2   
                 H 
                 CF 3   
                 Me 
                 198-201 
               
               
                 3.1133 
                 CCl 
                 CH 2 Br 
                 H 
                 CF 3   
                 Me 
                 151-153 
               
               
                 3.1134 
                 CCl 
                 Me 
                 H 
                 CF 3   
                 CH═CH 2   
                 Wax 
               
               
                 3.1135 
                 CCl 
                 Me 
                 H 
                 CF 3   
                 C≡CH 
                 Wax 
               
               
                 3.1136 
                 CCl 
                 CH 2 Cl 
                 H 
                 CF 3   
                 Me 
                 130-133 
               
               
                 3.1137 
                 CCl 
                 CH 2 NH 2   
                 H 
                 CF 3   
                 Me 
                 oil 
               
               
                   
               
            
           
         
       
     
     Biological Examples 
     1. Activity In Vitro Against  Rhipicephalus sanquineus  (Dog Tick) 
     A clean adult tick population is used to seed a suitably formatted 96-well plate containing the test substances to be evaluated for antiparasitic activity. Each compound is tested by serial dilution in order to determine its minimal effective dose (MED). Ticks are left in contact with the test compound for 10 minutes and are then incubated at 28° C. and 80% relative humidity for 7 days, during which the test compound&#39;s effect is monitored. Acaricidal activity is confirmed if adult ticks are dead. 
     In this test the compounds number 1.1-1.4, 1.6, 1.8-1.10, 1.12-1.15, 1.26-1.34, 1.38, 1.44, 1.45, 1.47-1.53, 1.56, 1.58-1.60-1.64, 1.66, 1.68, 1.70, 1.74-1.76, 1.80-1.83, 1.86, 1.89, 1.99, 1.110-1.112, 1.116-1.117, 1.121, 1.132, 1.138, 1.146, 1.153, 1.185, 1.194-1.196, 1.200, 1.204-1.207, 1.209-1.210, 1.212, 1.214, 1.216-1.222, 1.224-1.230, 1.234-1.239, 1.242-1.244, 1.246-1.247, 1.250, 1.251, 1.253-1.262, 2.4, 2.19, 2.20, 2.34, 2.38, 2.42, 2.44, 2.46-2.48, 3.1, 3.10, 3.59, 3.73, 3.1129-3.1131 and 3.1133-3.1136 showed more than 80% efficacy at 640 ppm. 
     2. Activity In Vitro Against  Ctenocephalides felis  (Cat Flea) 
     A mixed adult population of fleas is placed in a suitably formatted 96-well plate allowing fleas to access and feed on treated blood via an artificial feeding system. Each compound is tested by serial dilution in order to determine its MED. Fleas are fed on treated blood for 24 hours, after which the compound&#39;s effect is recorded. Insecticidal activity is determined on the basis of the number of dead fleas recovered from the feeding system. 
     In this test the compounds of tables 1.1-1.18, 1.20-1.35, 1.38-1.53, 1.55, 1.56, 1.58-1.71, 1.74-1.83, 1.85-1.89, 1.93-1.95, 1.99-1.101, 1.103, 1.104, 1.107-1.112, 1.114-1.118, 1.120, 1.121, 1.127, 1.129, 1.132, 1.133, 1.138, 1.146, 1.153, 1.185-1.239, 1.242-1.262, 2.2, 2.4, 2.6, 2.7, 2.12, 2.15, 2.19, 2.20, 2.26, 2.34, 2.38-2.55, 3.1, 3.59, 3.72, 3.73, 3.85, 3.124, 3.125 and 3.1126-3.1136 showed more than 80% efficacy at 100 ppm. 
     3. Activity In Vivo Against  Rhipicephalus sanguineus  (Dog Tick) on Rabbits 
     On day 0, rabbits are treated with the test compound at a given dose by spray application on their ears only. On day +1, the animals are infested on their ears with adult  R. sanguineus  ticks (sex ratio 1:1). Evaluation of efficacy is performed 24 h, 48 h, and 72 h after infestation by counting the numbers of dead and live ticks recovered from the animals. Efficacy is expressed as comparison with a placebo treated group using the Abbot&#39;s formula. Infestations are repeated at weekly intervals until efficacy drops. 
     In this test the compounds number 1.1, 1.3, 1.4, 1.6, 1.10, 1.12-1.15, 1.29, 1.31, 1.33, 1.38, 1.47-1.51, 1.53, 1.56, 1.58-1.60, 1.62, 1.63, 1.66, 1.74, 1.76, 1.80-1.82, 1.89, 1.111, 1.112, 1.117, 1.216-1.222, 1.225, 1.226, 1.228-1.230, 1.234, 1.238, 1.239, 2.20, 2.38, 2.44, 3.1, 3.73, 3.1133, 3.1135 and 3.1136 showed more than 80% efficacy at 240 mg/m 2  on the first infestation. 
     4. Activity In Vitro Against  Haemonchus contortus  &amp;  Trichostrongylus colubriformis  (Gastrointestinal Nematodes) 
     Freshly harvested and cleaned nematode eggs are used to seed a suitably formatted 96-well plate containing the test substances to be evaluated for antiparasitic activity. Each compound is tested by serial dilution in order to determine its MED. The test compounds are embedded in an agar-based nutritive medium allowing the full development of eggs through to 3 rd  instar larvae. The plates are incubated for 6 days at 25° C. and 60% relative humidity (RH). Egg-hatching and ensuing larval development are recorded to identify a possible nematodicidal activity. Efficacy is expressed in percent reduced egg hatch, reduced development of L3, or paralysis &amp; death of larvae of all stages. 
     In this test the compounds number 1.1-1.3, 1.28, 1.48, 1.50, 1.53, 1.58-1.1.60, 1.63, 1.64, 1.66, 1.68, 1.74, 1.77, 1.81, 1.108, 1.111, 1.115, 1.138, 1.146, 1.153, 1.192, 1.193, 1.207, 1.217, 1.220, 1.224, 1.225, 1.229, 1.234, 1.237, 1.244-1.246, 1.250, 1.254-1.260, 2.4, 2.6, 2.7, 2.12, 2.15, 2.19, 2.20, 2.26, 2.34, 2.36, 2.39, 2.43, 2.44, 3.59, 3.85 and 3.1131 showed more than 80% efficacy at 100 ppm.