Patent Publication Number: US-7220765-B2

Title: Derivatives of 2-arylimino-2,3-dihydrothiazoles, their preparation processes and their therapeutic use

Description:
This application is a Continuation-in-Part of U.S. patent application Ser. No. 10/031,429, now U.S. Pat. No. 6,727,269, filed Jan. 15, 2002 which is a 371 of PCT/FR02/00093, filed on Jan. 11, 2002. 
    
    
     A subject of the present Application is new derivatives of 2-arylimino-2,3-dihydrothiazoles and their preparation processes. These products have a good affinity with certain sub-types of somatostatin receptors and therefore have useful pharmacological properties. The invention also relates to these same products as medicaments, the pharmaceutical compositions containing them and their use for the preparation of a medicament intended to treat pathological states or diseases in which one (or more) somatostatin receptors are involved. 
     Somatostatin (SST) is a cyclic tetradecapeptide which was isolated for the first time from the hypothalamus as a substance which inhibits the growth hormone (Brazeau P. et al.,  Science  1973, 179, 77–79). It also operates as a neurotransmitter in the brain (Reisine T. et al.,  Neuroscience  1995, 67, 777–790; Reisine T. et al.,  Endocrinology  1995, 16, 427–442). Molecular cloning has allowed it to be shown that the bioactivity of somatostatin depends directly on a family of five receptors linked to the membrane. 
     The heterogeneity of the biological functions of somatostatin has lead to studies which try to identify the structure-activity relationships of peptide analogues on somatostatin receptors, which has led to the discovery of 5 sub-types of receptors (Yamada et al.,  Proc. Natl. Acad. Sci. U.S.A.,  89, 251–255, 1992; Raynor, K. et al, Mol. Pharmacol., 44, 385–392, 1993). The functional roles of these receptors are currently being actively studied. The affinities with different sub-types of somatostatin receptors have been associated with the treatment of the following disorders/diseases. Activation of sub-types 2 and 5 has been associated with suppression of the growth hormone (GH) and more particularly with that of adenomas secreting GH (acromegalia) and those secreting hormone TSH. Activation of sub-type 2 but not sub-type 5 has been associated with the treatment of adenomas secreting prolactin. Other indications associated with the activation of sub-types of somatostatin receptors are the recurrence of stenosis, inhibition of the secretion of insulin and/or of glucagon and in particular diabetes mellitus, hyperlipidemia, insensibility to insulin, Syndrome X, angiopathy, proliferative retinopathy, dawn phenomenon and nephropathy; inhibition of the secretion of gastric acid and in particular peptic ulcers, enterocutaneous and pancreaticocutaneous fistulae, irritable colon syndrome, dumping syndrome, aqueous diarrhoea syndrome, diarrhoea associated with ADS, diarrhoea induced by chemotherapy, acute or chronic pancreatitis and secretory gastrointestinal tumours; the treatment of cancer such as hepatomas; the inhibition of angiogenesis, the treatment of inflamatory disorders such as arthritis; chronic rejection of allografts; angioplasty; the prevention of bleeding of grafted vessels and gastrointestinal-bleeding. The agonists of somatostatin can also be used to reduce the weight of a patient. 
     Among the pathological disorders associated with somatostatin (Moreau J. P. et al., Life Sciences 1987, 40, 419; Harris A. G. et al.,  The European Journal of Medicine,  1993, 2, 97–105), there can be mentioned for example: acromegalia, hypophyseal adenomas, Cushing&#39;s disease, gonadotrophinomas and prolactinomas, catabolic side-effects of glucocorticoids, insulin dependent diabetes, diabetic retinopathy, diabetic nephropathy, hyperthyroidism, gigantism, endocrinic gastroenteropancreatic tumours including carcinoid syndrome, VIPoma, insulinoma, nesidioblastoma, hyperinsulinemia, glucagonoma, gastrinoma and Zollin-gr-Ellison&#39;s syndrome, GRFoma as well as acute bleeding of oesophageal veins, gastroesophageal reflux, gastroduodenal reflux, pancreatitis, enterocutaneous and pancreatic fistulae but also diarrhoea, refractory diarrhoea of acquired immune deficiency syndrome, chronic secretary diarrhoea, diarrhoea associated with irritable bowel syndrome, disorders linked with gastrin releasing peptide, secondary pathologies with intestinal grafts, portal hypertension as well as haemorrhages of the veins in patients with cirrhosis, gastro-intestinal haemorrhage, haemorrhage of the gastroduodenal ulcer, Crohn&#39;s disease, systemic scleroses, dumping syndrome, small intestine syndrome, hypotension, scleroderma and medullar thyroid carcinoma, illnesses linked with cell hyperproliferation such as cancers and more particularly breast cancer, prostate cancer, thyroid cancer as well as pancreatic cancer and colorectal cancer, fibroses and more particularly fibrosis of the kidney, fibrosis of the liver, fibrosis of the lung, fibrosis of the skin, also fibrosis of the central nervous system as well as that of the nose and fibrosis induced by chemotherapy, and other therapeutic fields such as, for example, cephaleas including cephalea associated with hypophyseal tumours, pain, panic attacks, chemotherapy, cicatrization of wounds, renal insufficiency resulting from delayed development, obesity and delayed development linked with obesity, delayed uterine development, dysplasia of the skeleton, Noonan&#39;s syndrome, sleep apnea syndrome, Graves&#39; disease, polycystic disease of the ovaries, pancreatic pseudocysts and ascites, leukemia, meningioma, cancerous cachexia, inhibition of H pylori, psoriasis, as well as The Applicant found that the compounds of general formula (I) described hereafter have an affinity and a selectivity for the somatostatin receptors. As somatostatin and its peptide analogues often have a poor bioavailability by oral route and a low selectivity (Robinson, C., Drugs of the Future, 1994, 19, 992; Reubi, J. C. et al., TIPS, 1995, 16, 110), said compounds, non-peptide agonists or antagonists of somatostatin, can be advantageously used to treat pathological states or illnesses as presented above and in which one (or more) somatostatin receptors are involved. Preferably, said compounds can be used for the treatment of acromegalia, hypophyseal adenomas or endocrine gastroenteropancreatic tumours including carcinoid syndrome. 
     The compounds of the present invention correspond to general formula (I) 
                         
in racemic, enantiomeric form or all combinations of these forms, in which:
 
R1 represents an amino(C 7 –C 7 )alkyl, aminoalkylarylalkyl, aminoalkylcycloalkylalkyl, (C 1 –C 15 )alkyl, (C 3 –C 7 )cycloalkyl, (C 1 –C 6 )alkyl(C 3 –C 6 )cycloalkyl, (C 3 –C 6 )cycloalkylalkyl, cyclohexenylalkyl, alkenyl, alkynyl, carbocyclic aryl radical containing at least two rings of which at least one is not aromatic, carbocyclic or heterocyclic aralkyl radical optionally substituted on the aryl group, bis-arylalkyl, alkoxyalkyl, furannylalkyl or tetrahydrofurannylalkyl, dialkylaminoalkyl, N-acetoamidoalkyl, cyanoalkyl, alkylthioalkyl, arylhydroxyalkyl, aralkoxyalkyl, morpholinoalkyl, pyrrolidinoalkyl, piperidinoalkyl, N-alkylpyrrolidinoalkyl, N-alkylpiperazinylalkyl or oxypyrrolidinoalkyl radical,
 
or R1 represents one of the radicals represented below:
 
                         
or also R1 represents a —C(R11)(R12)-CO-R10 radical;
 
R2 represents an optionally substituted carbocyclic or heterocyclic aryl radical,
 
or R2 represents one of the radicals represented below:
 
                         
R3 represents an alkyl, adamantyl, optionally substituted carbocyclic or heterocyclic aryl radical, carbocyclic or heterocyclic aralkyl optionally substituted on the aryl group,
 
or R3 represents one of the radicals represented below:
 
                         
or also R3 represents a —CO-R5 radical;
 
R4 represents H, alkyl, carbocyclic or heterocyclic aralkyl optionally situated on the aryl radical;
 
or then the
 
                         
radical represents a radical of general formula
 
                         
in which i represents an integer from 1 to 3;
 
R5 represents the N(R6)(R7) radical;
 
R6 represents a (C 1 –C 16 )alkyl, cycloalkylalkyl, hydroxyalkyl, aryloxyalkyl radical, carbocyclic or heterocyclic aralkyl radical optionally substituted on the aryl group, aralkoxyalkykl, arylhydroxyalkyl, alkoxyalkyl, alkylthioalkyl, alkenyl, alkynyl, cyclohexenyl, cyclohexenylalkyl, alkylthiohydroxyalkyl, cyanoalkyl, N-acetamidoalkyl radical, bis-arylalkyl radical optionally substituted on the aryl groups, di-arylalkyl radical optionally substituted on the aryl groups, morpholinoalkyl, pyrrolidinoalkyl, piperidinoalkyl, N-alkylpyrrolidinoalkyl, oxopyrrolidinoalkyl, tetrahydrofurannylalkyl, N-benzylpyrrolidinoalkyl, N-alkylpiperazinylalkyl, N-benzylpiperazinylalkyl, N-benzylpiperidinylalkyl or N-alkoxycarbonylpiperidinyl radical, or R6 represents a (C 3 –C 8 )cycloalkyl radical optionally substituted by a radical chosen from the group comprising the hydroxy radical and an alkyl radical,
 
or R6 represents one of the radicals represented below:
 
                         
R7 represents H or an alkyl, hydroxyalkyl, mono- or di-aminoalkyl or aralkyl radical; or the —N(R6)(R7) radical represents the radical of the following general formula:
 
                         
in which:
 
R8 represents H, alkyl, hydroxyalkyl, optionally substituted carbocyclic or heterocyclic aryl, aralkyl optionally substituted on the aryl group, alkenyl, alkoxyalkyl, cycloalkyl, cycloalkylalkyl, bis-arylalkyl, piperidinyl, pyrrolidinyl, hydroxy, arylalkenyl,
 
or R8 represents —X—(CH 2 ) b -R9;
 
R9 represents H or an alkyl, alkoxy, aryloxy, optionally substituted carbocyclic or heterocyclic aryl, morpholinyl, pyrrolidinyl, alkylamino or N,N′-(alkyl)(aryl)amino radical;
 
X represents CO, CO—NH or SO 2 ;
 
Y represents CH or N;
 
a represents 1 or 2;
 
b represents an integer from 0 to 6;
 
or the N(R6)(R7) radical represents a radical of general formula
 
                         
in which:
 
Z represents CH, O or S;
 
c represents an integer from 0 to 4;
 
or the N(R6)(R7) radical represents one of the radicals represented below:
 
                                           
R10 represents an amino(C 2 –C 7 )alkylamino, ((aminoalkyl)aryl)alkylamino, (aminoalkyl)cycloalkyl)alkylamino, piperazinyl, homopiperazinyl radical, or R10 represents the radical represented below:
 
                         
R11 represents H;
 
R12 represents H or an alkyl, (C 3 –C 7 )cycloalkyl, optionally substituted carbocyclic or heterocyclic aralkyl, propargyl, allyl, hydroxyalkyl, alkylthioalkyl, arylalkylalkoxyalkyl, arylalkylthioalkoxyalkyl radical;
 
or the compounds of the invention are salts of the compounds of general formula (I).
 
     When the compounds of general formula (I) contain the R1, R2, R3, R4, R6, R8, R9 or R12 radicals including a substituted aryl radical or an aralkyl substituted on the aryl group, said aryl or aralkyl radicals are preferably such that: 
     For R1, when the aryl group is substituted, it can be from 1 to 5 times (other than the bond which, links it with the remainder of the molecule) by radicals chosen independently from the group comprising a halogen atom and an alkyl, alkoxy, alkylthio, haloalkyl, haloalkoxy, aryl, aralkoxy or SO 2 NH 2  radical. Two substituents can, if appropriate, be linked together and form a ring, for example by representing together a methylenedioxy or propylene radical. 
     For R2, when the aryl group is substituted, it can be from 1 to 5 times (other than the bond which links it with the remainder of the molecule). The aryl radical can be substituted by radicals chosen independently from the group comprising a halogen atom and an alkyl, alkoxy, alkylthio, haloalkyl, alkenyl, haloalkoxy, nitro, cyano, azido, SO 2 N, mono- or di-alkylamino, aminoalkyl, aralkoxy, or aryl radical. Two substituents can, if appropriate, be linked together and form a ring, for example by representing together a methylenedioxy, ethylenedioxy or propylene radical. 
     For R3, when the aryl group or groups (originating from an aryl or aralkyl radical) are substituted, they can be, according to the case, from 1 to 5 times (other than the bond which links them with the remainder of the molecule). The carbocyclic aryl or aralkyl radicals can be substituted from 1 to 5 times on the aryl ring by radicals chosen independently from the group comprising a halogen atom and an alkyl, hydroxy, alkoxy, haloalkyl, haloalkoxy, nitro, cyano, azido, mono- or di-alkylamino, pyrrolidinyl, morpholinyl, aralkoxy or aryl radical. Two substituents can, if appropriate, be linked together and form a ring, for example by representing together an alkylenedioxy radical containing 1 to 3 carbon atoms. The heterocyclic aryl or aralkyl radicals of R3 can be substituted 1 to 2 times on the ring by radicals chosen independently from the group comprising a halogen atom and an alkyl radical. 
     For R4, when the aryl group is substituted, it can be from 1 to 5 times (other than the bond which links it with the remainder of the molecule). The aryl radical can be substituted by the radicals chosen independently from the group comprising a halogen atom and an alkyl or alkoxy radical. 
     For R6, when the aryl group or groups are substituted, they can be from 1 to 5 times (other than the bond which links them with the remainder of the molecule). The optional substituents on the aryl groups are chosen independently from the group comprising a halogen atom and an alkyl, alkoxy, alkylthio, haloalkyl, haloalkoxy, aryl, aryloxy or SO 2 NH 2  radical. 
     For R8, when the aryl croup or groups are substituted, they can be from 1 to 5 times (other than the bond which links them with the remainder of the molecule). The optional substituents on the aryl groups are chosen independently from the group comprising a halogen atom and an alkyl, haloalkyl, alkoxy, hydroxy, cyano, nitro or alkylthio radical. 
     For R9, when the carbocyclic or heterocyclic aryl radical is substituted, it can be from 1 to 5 times (other than the bond which links it with the remainder of the molecule). The optional substituents on the aryl group are chosen independently from the group comprising a halogen atom and an alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, carbocyclic aryl, hydroxy, cyano or nitro radical. 
     For R12, when the carbocyclic or heterocyclic aryl radical is substituted, it can be from 1 to 5 times (other than the bond which links it with the remainder of the molecule). The optional substituents on the aryl group are chosen independently from the group comprising a halogen atom and an alkyl alkoxy, carbocyclic aryl, aralkoxy, hydroxy, cyano or nitro radical. 
     By alkyl, unless specified otherwise, is meant a linear or branched alkyl radical containing 1 to 6 carbon atoms. By cycloalkyl, unless specified otherwise, is meant a monocyclic carbon system containing 3 to 7 carbon atoms. By alkenyl, unless specified otherwise, is meant a linear or branched alkyl radical containing 1 to 6 carbon atoms and having at least one unsaturation (double bond). By alkynyl, unless specified otherwise, is meant a linear or branched alkyl radical containing 1 to 6 carbon atoms and having at least one double unsaturation (triple bond). By carbocyclic or heterocyclic aryl, is meant a carbocyclic or heterocyclic system containing at least one aromatic ring, a system being referred to as heterocyclic when at least one of the rings which comprise it contains a heteroatom (O, N or S). By haloalkyl, is meant an alkyl radical of which at least one of the hydrogen atoms (and optionally all) is replaced by a halogen atom. 
     By alkylthio, alkoxy, haloalkyl, haloalkoxy, aminoalkyl, alkenyl, alkynyl and aralkyl radicals, is meant respectively the alkylthio, alkoxy, haloalkyl, haloalkoxy, aminoalkyl, alkenyl, alkynyl and aralkyl radicals the alkyl radical of which has the meaning indicated previously. 
     By linear or branched alkyl having 1 to 6 carbon atoms, is meant in particular the methyl, ethyl, propyl, isopropyl, butyl, isobutyl, sec-butyl and tert-butyl, pentyl, neopentyl, isopentyl, hexyl, isohexyl radicals. By cycloalkyl, is meant in particular the cyclopropanyl, cyclobutanyl, cyclopentanyl, cyclohexyl and cycloheptanyl radicals. By carbocyclic or heterocyclic aryl, is meant, in particular the phenyl, naphthyl, pyridinyl, furannyl, thiophenyl, indanyl, indolyl, imidazolyl, benzofurannyl, benzothiophehyl, phthalimidyl radicals. By carbocyclic or heterocyclic aralkyl, is meant in particular the benzyl, phenylethyl, phenylpropyl, phenylbutyl, indolylalkyl, phthalimidoalkyl, naphthylalkyl, furannylalkyl, thiophenylalkyl, benzothiophenylalkyl, pyridinylalkyl and imidazolylalkyl radicals. 
     When an arrow emanates from a chemical structure, said arrow indicates the point of attachment. For exemple: 
                         
represents the benzyl radical.
 
     Preferably, the compounds of general formula (I) are such that: 
     R1 represents —C(R11)(R12)-CO-R10 or one of the following radicals: 
                                                                                                                                                       
R2 represents one of the following radicals:
 
                                           
R3 represents CO-R5 or one of the following radicals:
 
                                           
R4 represents H, alkyl, carbocyclic or heterocyclic aralkyl optionally substituted on the aryl radical;
 
or then the
 
                         
radical represents a radical of general formula
 
                         
in which i represents an integer from 1 to 3;
 
R5 represents one of the following radicals:
 
                                                                                                                                                                                                                               
R10 represents one of the following radicals:
 
     
       
         
         
             
             
         
       
     
                         
R11 represents H;
 
R12 represents one of the following radicals:
 
                                           
it being understood that for R4, when the aryl group is substituted, it can be from 1 to 5 times (other than the bond which links it with the remainder of the molecule) by radicals chosen independently from the group comprising a halogen atom and an alkyl or alkoxy radical.
 
     The compounds of the invention are preferably such that R4 represents H. 
     More preferentially, the compounds according to the invention correspond to general formula (II) 
                         
in which:
         either R1 represents one of the radicals below       
     
       
         
         
             
             
         
       
         
         
           
             R2 represents one of the radicals below 
           
         
       
    
     
       
         
         
             
             
         
       
         
         
           
             R3 represents one of the radicals below 
           
         
       
    
     
       
         
         
             
             
         
       
         
         
           
             and R4 represents H; 
             or also R1 represents one of the radicals below 
           
         
       
    
     
       
         
         
             
             
         
       
         
         
           
             R2 represents one of the radicals below 
           
         
       
    
     
       
         
         
             
             
         
       
         
         
           
             R3 represents COR5, 
             R4 represents H, 
             and R5 represents one of the radicals below 
           
         
       
    
     
       
         
         
             
             
         
       
         
         
           
             or finally R1 represents the —C(R11)(R12)-CO-R10 radical in which 
             R10 represents the radical 
           
         
       
    
     
       
         
         
             
             
         
       
         
         
           
             R11 represents H 
             and R12 represents the radical 
           
         
       
    
     
       
         
         
             
             
         
       
         
         
           
             R2 represents the radical 
           
         
       
    
     
       
         
         
             
             
         
       
         
         
           
             R3 represents the radical 
           
         
       
    
     
       
         
         
             
             
         
       
         
         
           
             and R4 represents H. 
           
         
       
    
     The invention also relates to a compound characterized in that it corresponds: to formula 
                         
in which:
 
     R2 represents the 
                         
radical and R5 represents the
 
                         
radical,
 
     R2 represents the 
                         
radical and R5 represents the
 
                         
radical,
 
     R2 represents the 
                         
radical and R5 represents the
 
                         
radical,
 
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radical and R5 represents the
 
                         
radical,
 
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radical,
 
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radical,
 
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radical,
 
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radical,
 
     R2 represents the 
                         
radical and R5 represents the
 
     
       
         
         
             
             
         
       
     
     R2 represents the 
                         
radical and R5 represents the
 
                         
radical,
 
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radical,
 
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radical,
 
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radical,
 
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radical,
 
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radical,
 
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radical,
 
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radical,
 
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radical,
 
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radical,
 
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radical,
 
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radical,
 
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radical,
 
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radical,
 
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radical and R5 represents the
 
                         
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radical and R5 represents the
 
                         
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radical and R5 represents the
 
                         
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     R2 represents the 
                         
radical and R5 represents the
 
                         
radical.
 
     R2 represents the 
                         
radical and R5 represents the
 
                         
radical, or finally
 
     R2 represents the 
                         
radical and R5 represents the
 
                         
radical;
         to formula       
                         
in which:
 
     R10 represents 
                         
R2 represents
 
                         
and R3 represents
 
     
       
         
         
             
             
         
       
     
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     to formula 
                         
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     to formula 
                         
in which:
 
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or a salt of one of these compounds.
 
     Even more preferentially, the invention relates to a compound characterized in that it corresponds to the formula 
                         
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or a salt of one of these compounds.
 
     In other words, the compounds described in Examples 1642 to 1654, 1656 to 1680, 2468 to 2502, 2525 to 2550, 2556 to 2582, 2605 to 2611, 2614, 2623 to 2630, 2632 to 2646, 2670 to 2678, 2680 to 2694, 2702 to 2710, 2712 to 2726 and 2827 to 2836 or a salt of one of these compounds will be preferred. The compounds of Examples 2827 to 2836 or their salts will be even more particularly preferred. 
     Moreover, the invention relates to preparation processes on a solid support for the compounds of general formula (I) described previously (also applicable to the corresponding compounds of general formula (II)). 
     According to the invention, the compounds of general formula (I)a 
                         
in which:
 
R1 represents a —CH 2 -A1-NH 2  radical, in which A1 represents a —(CH 2 ) n —, —(CH 2 ) n —O—(CH 2 ) p —, aralkylene or cycloalkylalkylene radical, n and p represent integers from 1 to 6;
 
R2 and R4 represent the same radicals as in general formula (I);
 
and R3 represents the same radicals as in general formula (I), with the exception of the —CO-R5 radicals;
 
can be prepared for example according to a process characterized in that it comprises the following successive stages:
 
1) treatment, in an aprotic solvent such as dichloromethane or dimethylformamide, of a p-nitrophenylcarbonate Wang resin with a large excess of R1-NH 2  symmetrical diamine;
 
2) treatment, in an aprotic solvent such as dichloromethane or dimethylformamide, of the resin isolated after stage 1) with an aromatic isothiocyanate of general formula R2-N═C═S in which the R2 radical has the same meaning as in general formula (I)a;
 
3) treatment, in an aprotic solvent such as dioxane or dimethylformamide, of the resin obtained in Stage 2) with the compound of general formula (III)
 
                         
in which the R3 and R4 radicals have the same meaning as in general formula (I)a;
 
4) cleavage of the resin under acid conditions;
 
5) treatment under basic conditions of the product obtained after Stage 4).
 
     The preparation of the p-nitrophenylcarbonate Wang resin is described further on in the part entitled “PREPARATION OF THE COMPOUNDS OF THE INVENTION”. 
     Preferably, for the above process, in order to have the large excess in Stage 1), of the order of 10 to 20 equivalents of diamine R1-NH 2  will be used Stage 1) is preferably carried out at ambient temperature. Stage 3) is carried out at a temperature greater than ambient temperature, for example at a temperature comprised between 60 and 90° C., using of the order of 2 to 5 equivalents of the compound of general formula (III). In Stage 4), the acid conditions can for example be created by using a dichloromethane/trifluroacetic acid mixture at 50%, said acid conditions being preferably maintained for a duration of the order of 1 to 2 hours. In Stage 5), the basic conditions can for example be created by using a saturated solution of sodium hydrogen carbonate or by elution on a basic alumina cartridge. 
     According to a variant of the invention, the compounds of general formula (I)b 
                         
in which:
 
R1 represents the same radicals as in general formula (1), with the exception of the —CH 2 -A1-NH 2  type radicals, in which A1 represents a —(CH 2 ) n —, —(CH 2 ) n —O—(CH 2 ) p —, aralkylene or cycloalkylalkylene radical, n and p representing integers from 1 to 6, and also with the exception of the —C(R11)(R12)-CO-R10 radicals;
 
R2 represents an aminoalkylphenyl radical;
 
R3 represents the same radicals as in general formula (I), with the exception of the —CO-R5 radicals;
 
can be prepared for example according to a process characterized in that it comprises the following successive stages:
 
1) treatment, in an aprotic solvent such as dichloromethane or dimethylformamide, of a Wang resin p-nitrophenylcarbonate with an excess of aminoalkylaniline of general formula R2-NH 2  in which the R2 radical has the same meaning as in general formula (I)b;
 
2) treatment, in an aprotic solvent such as dichloromethane or dimethylformamide, of the resin isolated after Stage 1) with an isothiocyanate of general formula R1-N═C═S in which the R1 radical has the same meaning as in general formula (I)b;
 
3) treatment, in an aprotic solvent such as dioxane or dimethylformamide, of the resin obtained in Stage 2) with the compound of general formula (III)
 
                         
in which the R3 and R4 radicals have the same meaning as in general formula (I)b;
 
4) cleavage of the resin under acid conditions;
 
5) treatment under basic conditions of the product obtained after Stage 4).
 
     Preferably, for the above process, in order to have the excess in Stage 1), of the order of 5 to 10 equivalents of aminoalkylaniline will be used. Stage 1) is preferably carried out at ambient temperature. Stage 3) is carried out at a temperature greater than ambient temperature, for example at a temperature comprised between 60 and 90° C., using of the order of 2 to 5 equivalents of the compound of general formula (III). In Stage 4), the acid conditions can for example be created by using a dichloromethane/trifluoroacetic acid mixture at 50%, said acid conditions being preferably maintained for a duration of the order of 1 to 2 hours. In Stage 5), the basic conditions can for example be created by using a saturated solution of sodium hydrogen carbonate or by elution on a basic alumina cartridge. 
     According to another variant of the invention, the compounds of general formula (I)c 
                         
in which:
 
R1 represents a —CH 2 -A1-NH 2  radical, in which A1 represents a —(CH 2 ) n —, —(CH 2 ) n —O—(CH 2 ) p —, aralkylene or cycloalkylalkylene radical, n and p representing integers from 1 to 6;
 
R2 represents the same radicals as in general formula (I);
 
R3 represents a —CO-R5 radical;
 
and R4 and R5 represent the same radicals as in general formula (I);
 
can be prepared according to a process characterized in that it comprises the following successive stages:
 
1) treatment, in an aprotic solvent such as dichloromethane or dimethylformamide, of a Wang resin p-nitrophenylcarbonate with a large excess of symmetrical diamine of general formula R1-NH 2  in which the R1 radical has the same meaning as in general formula (I)c;
 
2) treatment, in an aprotic solvent such as dichloromethane or dimethylformamide, of the resin isolated after Stage 1) with an aromatic isothiocyanate of general formula R2-N═C═S in which the R2 radical has the same meaning as in general formula (I)c;
 
3) treatment, in an aprotic solvent such as dioxane or dimethylformamide, of the resin obtained in Stage 2) with the acid of general formula (IV)
 
                         
in which the R4 radical has the same meaning as in general formula (I)c;
 
4) peptide coupling;
 
5) cleavage of the resin under acid conditions;
 
6) treatment under basic conditions of the product obtained after Stage 5).
 
     Preferably, for the above process, in order to have the large excess in Stage 1) of the order of 10 to 20 equivalents of symmetrical diamine will be used. Stage 1) is preferably carried out at ambient temperature. Stage 3) is carried out at, a temperature greater than ambient temperature, for example at a temperature comprised between 60 and 90° C., using of the order of 2 to 5 equivalents of the acid of general formula (IV). The peptide coupling of Stage 4) is carried out for example in DMF with coupling agents such as for example dicyclohexylcarbodiimide (DCC), diisopropylcarbodiimide (DIC), a DIC/N-hydroxybenzotriazole (HOBt) mixture, benzotriazolyloxytris(dimethylamino)phosphonium hexafluorophosphate (PyBOP), 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) or 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) and aminated compounds. Preferably, the coupling agents are used in proportions of 4 to 5 equivalents, as with the aminated compounds, and the reaction will take place at a temperature of the order of ambient temperature for a duration of the order of 1 to 24 hours. In Stage 5), the acid conditions can for example be created by using a dichloromethane/trifluoroacetic acid mixture at 50%, said acid conditions being preferably maintained for a duration of the order of 1 to 2 hours. In Stage 6), the basic conditions can for example be created by using a saturated solution of sodium hydrogen carbonate or by elution on a basic alumina cartridge. 
     According to yet another variant, the compounds of general formula (I)d 
                         
in which:
 
R1 represents the same radicals as in general formula (I), with the exception of the —CH 2 -A1-NH 2  type radicals, in which A1 represents a —(CH 2 ) n —, —(CH 2 ) n —O—(CH 2 ) p —,
 
aralkylene or cycloalkylalkylene radical, n and p represent integers from 1 to 6, and also with the exception of the —C(R11)(R12)-CO-R10 radicals;
 
R2 represents an aminoalkylphenyl radical;
 
R3 represents a —CO-R5 radical;
 
and R4 and R5 represent the same radicals as in general formula (I);
 
can be prepared according to a process characterized in that it comprises the following successive stages:
 
1) treatment, in an aprotic solvent such as dichloromethane or dimethylformamide, of a Wang resin p-nitrophenylcarbonate with an excess of aminoalkylaniline of general formula R2-NH 2  in which the R2 radical has the same meaning as in general formula (I)d;
 
2) treatment, in an aprotic solvent such as dichloromethane or dimethylformamide, of the resin isolated after Stage 1) with an isothiocyanate of general formula R1-N═C═S in which the R1 radical has the same meaning as in general formula (I)d;
 
3) treatment, in an aprotic solvent such as dioxane or dimethylformamide, of the resin obtained in Stage 2) with the acid of general formula (IV)
 
                         
in which the R4 radical has the same meaning as in general formula (I)d;
 
4) peptide coupling;
 
5) cleavage of the resin under acid conditions;
 
6) treatment under basic conditions of the product obtained after Stage 5).
 
     Preferably, for the above process, in order to have the excess in Stage 1), of the order of 5 to 10 equivalents of aminoalkylaniline will be used. Stage 1) is preferably carried out at ambient temperature. Stage 3) is carried out at a temperature greater than ambient temperature, for example at a temperature comprised between 60 and 90° C., using of the order of 2 to 5 equivalents of the acid of general formula (IV). The peptide coupling of Stage 4) is carried out for example in DMF with coupling agents such as for example dicyclohexylcarbodiimide (DCC), diisopropylcarbodiimide (DIC), a DIC/N-hydroxybenzotriazole (HOBt) mixture, benzotriazolyloxytris(dim ethylamino) phosphonium hexafluorophosphate (PyBOP), 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) or 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) and aminated compounds. Preferably, the coupling agents are used in proportions of 4 to 5 equivalents, as with the aminated compounds, and the reaction will take place at a temperature of the order of ambient temperature for a duration of the order of 1 to 24 hours. In Stage 5), the acid conditions can for example be created by using a dichloromethane/trifluoroacetic acid mixture at 50%, said acid conditions being preferably maintained for a duration of the order of 1 to 2 hours. In Stage 6), the basic conditions can for example be created by using a saturated solution of sodium hydrogen carbonate or by elution on a basic alumina cartridge. 
     According to another variant the compounds of general formula (I)e 
                         
in which:
 
R1 represents the same radicals as in general formula (I), with the exception of the —CH 2 -A1-NH 2  type radicals, in which A1 represents a —(CH 2 ) n —, —(CH 2 ) n —O—(CH 2 ) p —, aralkylene or cycloalkylalkylene radical, n and p representing integers from 1 to 6, and also with the exception of the —C(R11)(R12)CO-R10 radicals;
 
R2 represents the same radicals as in general formula (I);
 
R3 represents a —CO-R5 radical;
 
R4 represents H;
 
R5 represents an —NH—CH 2 -A1-NH 2  radical, in which A1 represents a linear or branched alkylene radical containing 1 to 6 carbon atoms, —(CH 2 ) n —O—(CH 2 ) p —,
 
aralkylene or cycloalkylalkylene, n and p representing integers from 1 to 6, or also R5 represents the N(R6)(R7) radical corresponding to the following general formula:
 
                         
in which:
 
R8 represents H;
 
Y represents N;
 
a represents 1 or 2;
 
can be prepared by a process characterized in that it comprises the following successive stages:
 
1) treatment, in an aprotic solvent such as dichloromethane or dimethylformamide, of a Wang resin p-nitrophenylcarbonate with a large excess of symmetrical diamine of general formula R5-H;
 
2) peptide coupling with the acid of general formula (IV) on the resin obtained in Stage 1)
 
                         
in which the R4 radical has the same meaning as in general formula (I)e;
 
3) reaction of the primary amine of general formula R1-NH 2  with the isothiocyanate of general formula R2-NCS in a solvent such as dimethylformamide or dioxane, R1 and R2 having the same meanings as in general formula (I)e;
 
4) addition of the thiourea obtained in Stage 3) to the resin obtained in Stage 2) and heating the mixture;
 
5) cleavage of the resin under acid conditions;
 
6) treatment under basic conditions of the product obtained after Stage 5).
 
     Preferably, for the above process, in order to have the large excess in Stage 1), of the order of 10 to 20 equivalents of diamine R5-H will be used. Stage 1) is preferably carried out at ambient temperature. The peptide coupling of Stage 2) is carried out in DMF with a coupling agent such as for example the DIC/N-hydroxybenzotriazole (HOBt) mixture. Preferably, the reaction of Stage 3) is carried out in a solvent such as dimethylformamide or dioxane. During the addition of Stage 4), 2 to 5 equivalents of thiourea will preferably be used per equivalent of resin; preferably also, heating will be carried out at a temperature greater than ambient temperature, for example at a temperature from 40 to 100° C. (in particular at a temperature of approximately 80° C.) and for a duration of 2 to 24 hours. In Stage 5), the acid conditions can for example be created by using a dichloromethane/trifluoroacetic acid mixture at 50%, said acid conditions being preferably maintained for a duration of the order of 1 to 2 hours. In Stage 6), the basic conditions can for example be created by using a saturated solution of sodium hydrogen carbonate or by elution on a basic alumina cartridge. 
     According to yet another variant, the compounds of general formula (I)f 
                         
in which:
 
R1 represents a —C(R11)(R12)-CO-R10 radical;
 
R2, R3 and R4 represent the same radicals as in general formula (I);
 
R10 represents an amino(C 2 –C 7 )alkylamino, ((aminoalkyl)aryl)alkylamino, ((aminoalkyl)cycloalkyl)alkylamino, piperazinyl, homopiperazinyl radical,
 
or R10 represents the radical represented below:
 
                         
R11 represents H;
 
R12 represents H or an alkyl, (C 3 –C 7 )cycloalkyl, optionally substituted carbocyclic or heterocyclic aralkyl, propargyl, allyl, hydroxyalkyl, alkylthioalkyl, arylalkyl alkoxyalkyl, arylalkylthioalkoxyalkyl radical;
 
can be prepared by a process characterized in that it comprises the following successive stages:
 
1) treatment, in an aprotic solvent such as dichloromethane or dimethylformamide, of a Wang resin p-nitrophenylcarbonate with a large excess of symmetrical diamine of general formula R10-H in which R10 has the same meaning as in general formula (I)f;
 
2) peptide coupling of the resin obtained in Stage 1) with an amino acid of general formula HOOC—C(R11)(R12)-NH-Fmoc in which R11 and R12 have the same meaning as in general formula (I)f;
 
3) cleavage of the Fmoc group from the resin obtained in Stage 2);
 
4) reaction of the resin obtained in Stage 3) with an isothiocyanate of general formula R2-NCS in which R2 has the same meaning as in general formula (I)f;
 
5) cleavage of the resin under acid conditions;
 
6) treatment under basic conditions of the product obtained after Stage 5).
 
     Preferably, for the above process, in order to have the large excess in Stage 1), of the order of 10 to 20 equivalents of diamine R10-H will be used. Stage 1) is preferably carried out at ambient temperature. The peptide coupling of Stage 2) is carried out for example in DMF with coupling agents such as for example dicyclohexylcarbodiimide (DCC), diisopropylcarbodiimide (DIC), a DIC/N-hydroxybenzotriazole (HOBt) mixture, benzotriazolyloxytris(dimethylamino) phosphonium hexafluorophosphate (PyBOP), 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) or 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU). Preferably, the reaction of Stage 2) is carried out at ambient temperature and for a duration of 1 to 24 hours. The deprotection of Stage 3) can be carried out, for example, by a mixture of DMF containing 20% piperidine. Stage 4) will preferably be carried out in a solvent such as dimethylformamide or dichloromethane, the isothiocyanate preferably being added in a proportion of 5 to 10 equivalents per equivalent of the resin obtained in Stage 3). In Stage 5), the acid conditions can for example be created by using a dichloromethane/trifluoroacetic acid mixture at 50% said acid conditions being preferably maintained for a duration of the order of 1 to 2 hours. In Stage 6), the basic conditions can for example be created by using a saturated solution of sodium hydrogen carbonate or by elution on a basic alumina cartridge. 
     A subject of the invention is also, as medicaments, the compounds of general formulae (I) and (II) described previously or their pharmaceutically acceptable salts. It also relates to pharmaceutical compositions containing said compounds or their pharmaceutically acceptable salts, and their use for the preparation of a medicament intended to treat pathological states or diseases in which one (or more) of the somatostatin receptors are involved. 
     In particular, the compounds of general formulae (I) and (II) described previously or their pharmaceutically acceptable salts can be used for the preparation of a medicament intended to treat pathological states or diseases chosen from the group comprising the following pathological states or diseases: acromegalia, hypophyseal adenomas, Cushing&#39;s disease, gonadotrophinomas and prolactinomas, catabolic side-effects of glucocorticoids, insulin dependent diabetes, diabetic retinopathy, diabetic nephropathy, syndrome X, dawn phenomenon, angiopathy, angioplasty, hyperthyroidism, gigantism, endocrinic gastroenteropancreatic tumours including carcinoid syndrome, VIPoma, insulinoma, nesidioblastoma, hyperinsulinemia, glucagonoma, gastrinoma and Zollinsger-Ellison&#39;s syndrome, GRFoma as well as acute bleeding of the esophageal veins, ulcers, gastroesophageal reflux, gastroduodenal reflux, pancreatitis, enterocutaneous and pancreatic fistulae but also diarrhoea, refractory diarrhoea&#39;s of acquired immunodeficiency syndrome, chronic secretary diarrhoea, diarrhoea associated with irritable bowel syndrome, diarrhoea&#39;s induced by chemotherapy, disorders linked with gastrin releasing peptide, secondary pathologies with intestinal grafts, portal hypertension as well as haemorrhages of the veins in patients, with cirrhosis, gastro-intestinal haemorrhage, haemorrhage of the gastroduodenal ulcer, bleeding of grafted vessels, Crohn&#39;s disease, systemic scleroses, dumping syndrome, small intestine syndrome, hypotension, scleroderma and medullar thyroid carcinoma, illnesses linked with cell hyperproliferation such as cancers and more particularly breast cancer, prostate cancer, thyroid cancer as well as pancreatic cancer and colorectal cancer, fibroses and more particularly fibrosis of the kidney, fibrosis of the liver, fibrosis of the lung, fibrosis of the skin, also fibrosis of the central nervous system as well as that of the nose and fibrosis induced by chemotherapy, and in other therapeutic fields such as, for example, cephaleas including cephalea associated with hypophyseal tumours, pain, inflammatory disorders such as arthritis, panic attacks, chemotherapy, cicatrization of wounds, renal insufficiency resulting from delayed development, hyperlipidemia, obesity and delayed development linked with obesity, delayed uterine development, dysplasia of the skeleton, Noonan&#39;s syndrome, sleep apnea syndrome, Graves&#39; disease, polycystic disease of the ovaries, pancreatic pseudocysts and ascites, leukemia, meningioma, cancerous cachexia, inhibition of H pylori, psoriasis, chronic rejection of allografts as well as Alzheimer&#39;s disease and finally osteoporisis. 
     Preferably, the compounds of general formulae (I) and (II) described previously or their pharmaceutically acceptable salts can be used for the preparation of a medicament intended to treat the pathological states or diseases chosen from the group comprising the following pathological states, or diseases: acromegalia, hypophyseal adenomas or endocrinic gastroenteropancreatic tumors including carcinoid syndrome, and gastrointestinal bleeding. 
     By pharmaceutically acceptable salt is meant in particular addition salts of inorganic acids such as hydrochloride, sulphate, phosphate, diphosphate, hydrobromide and nitrate, or of organic acids, such as acetate, maleate, fumarate, tartrate, succinate, citrate, lactate, methanesulphonate, p-toluenesulphonate, pamoate, oxalate and stearate. The salts formed from bases such as sodium or potassium hydroxide also fall within the scope of the present invention, when they can be used. For other examples of pharmaceutically acceptable salts, reference can be made to “Pharmaceutical salts”,  J. Pharm. Sci.  66:1 (1977). 
     The pharmaceutical composition can be in the form of a solid, for example powders, granules, tablets, capsules, liposomes or suppositories. Appropriate solid supports can be for example calcium phosphate, magnesium stearate, talc, sugars, lactose, dextrin, starch, gelatin, cellulose, methyl cellulose, sodium carboxymethyl cellulose, polyvinylpyrrolidine and wax. The suspensions contain in particular suspensions of sustained release microparticles loaded with active ingredient (in particular microparticles of polylactide-co-glycolide or PLGA—cf. for example the patents U.S. Pat. No. 3,773,919, EP 52 510 or EP 58 481 or the Patent Application PCT WO 98/47489), which allow the administration of a determined daily dose over a period of several days to several weeks. 
     The pharmaceutical compositions containing a compound of the invention can also be presented in the form of a liquid, for example, solutions, emulsions, suspensions or syrups. Appropriate liquid supports can be, for example, water, organic solvents such as glycerol or glycols, as well as their mixtures, in varying proportions, in water. 
     The administration of a medicament according to the invention can be carried out by topical, oral, parenteral route, by intramuscular injection, etc. 
     The administration dose envisaged for a medicament according to the invention is comprised between 0.1 mg and 10 g according to the type of active compound used. 
     These compounds can be prepared according to the methods described below. 
     Preparation of the Compounds of the Invention 
     I) Preparation of α-bromoketones 
     First Method 
     This method is inspired by the protocols described in the following publications: Macholan, L.; Skursky, L.  Chem. Listy  1955, 49, 1385–1388; Bestman, H. J.; Seng, F.  Chem. Ber.  1963, 96, 465–469; Jones, R. G.; Kornfeld, E. C.; McLaughlin, K. C.  J. Am. Chem. Soc.  1950, 72, 4526–4529; Nimgirawath, S.; Ritchie, E.; Taylor, W. C.  Aust. J. Chem.  1973, 26, 183–193). 
     
       
         
         
             
             
         
       
     
     A carboxylic acid is firstly converted to an acid by using oxalyl or thionyl chloride, or by activating it in the form of an anhydride using an alkyl chloroformate (for example isobutyl chloroformate, cf. Krantz, A.; Copp, L. J.  Biochemistry  1991, 30, 4678–4687; or ethyl chloroformate, cf. Podlech, J.; Seebach, D.  Liebigs Ann.  1995, 1217–1228) in the presence of a base (triethylamine or N-methylmorpholine). 
     The activated carboxyl group is then converted to diazoketone using diazomethane in an ethereal solution or a commercial solution of trimethylsilyldiazomethane (Aoyama, T.; Shiori, T.  Chem. Pharm. Bull.  1981, 29, 3249–3255) in an aprotic solvent such as diethyl ether, tetrahydrofuran (THF) or acetonitrile. 
     The bromination is then carried out using a bromination agent such as hydrobromic acid in acetic acid, aqueous hydrobromic acid in diethyl ether or dichloromethane. 
     Preparation 1 
     2-(4-bromo-3-oxobutyl)-1H-isoindole-1,3 (2H)-dione 
     (C 12 H 10 BrNO 3 , MM=296.12) 
     
       
         
         
             
             
         
       
     
     Oxalyl chloride (5.8 ml; 66.7 mmol) is added to Pht-β-Ala-OH (9.96 g; 44.5 mmol) dissolved in dichloromethane (120 ml) and 3 drops of dimethylformamide (DMF). The mixture is agitated for 3 hours at ambient temperature. After elimination of the solvent, the white solid is taken up in a 1:1 mixture of anhydrous tetrahydrofuran and acetonitrile (200 ml) then 49 ml of a 2M solution of (trimethylsilyl) diazomethane in hexane (97.9 mmol) is added dropwise at 0° C. The solvents are eliminated after agitation overnight at 0° C. The pale yellow solid is then dissolved in dichloromethane (60 ml) and 12 ml of aqueous hydrobromic acid (48%) is added dropwise at 0° C. The mixture is agitated until the temperature reaches 15° C. and 50 ml of a saturated solution of sodium bicarbonate is added. The organic phase is washed with salt water then dried over sodium sulphate. Crystallization from diethyl ether allows a white solid to be obtained (11.39 g; yield=86%). 
     NMR  1 H (DMSO D6, 100 MHz, δ): 7.83 (s, 4H); 4.36 (s, 2H, CH 2 Br); 3.8 (t, 2H, J=7.1 Hz, NCH 2 ); 2.98 (t, 2H, J=6.9 Hz, CH 2 CO). 
     Preparations 2–11 
     The following compounds were prepared in a similar fashion to the procedure described in Preparation 1: 
     
       
         
         
             
             
         
       
     
                                     Prep.   R3   Yield (%)                  2*                         78               3*                         60               4*                         10               5*                         69               6*                         41               7                          67               8                          51               9                          38               10                          22               11                          67               *Compounds already described in the literature.            
Second Method
 
     The starting product is an arylmethylketone or a heteroarylmethylketone. 
     
       
         
         
             
             
         
       
     
     The starting arylmethylketone or heteroarylmethylketone is converted to the corresponding α-bromoketone by using different brominating agents: 
     CuBr 2  (King, L. C.; Ostrum, G. K.  J. Org. Chem.  1964, 29, 3459–3461) heated in ethyl acetate or dioxane; 
     N-bromosuccinimide in CCl 4  or aqueous acetonitrile (Morton, H. E.; Leanna, M. R.  Tetrahedron Lett.  1993, 34, 4481–4484); 
     bromine in glacial acetic acid or sulphuric acid; 
     phenyltrimethylammonium tribromide (Sanchez, J. P.; Parcell, R. P.  J. Heterocyclic Chem,  1988, 25, 469–474) at 20–80° C. in an aprotic solvent such as THF or tetrabutylammonium tribromide (Kajigaeshi, S.; Kakinami, T.; Okamoto, T.; Fujisaki,  S. Bull Chem. Soc. Jpn.  1987, 60, 1159–1160) in a dichloromethane/methanol mixture at ambient temperature; 
     brominating agent on a polymer support such as perbromide on an Amberlyst A-26 resin, poly(perbromide of vinylpyridinium hydrobromide) (Frechet, J. M. J.; Farrall, M. J.  J. Macromol. Sci. Chem.  1977, 507–514) in a protic solvent such as methanol at approximately 20–35° C. for approximately 2–10 hours. 
     Preparation 12 
     1-(1-benzofuran-2-yl)-2-bromo-1-ethanone 
     (C 10 H 7 BrO 2 , MM=239.06) 
     
       
         
         
             
             
         
       
     
     A polymer of perbromide of pyridine hydrobromide (8.75 g; 17.5 mmol; 1.4 equivalent) is added to a solution of (benzofuran-2-yl)methylketone (2 g; 12.5 mmol) in methanol (40 ml). The resulting mixture is agitated at ambient temperature for 7 hours and the reaction is stopped by filtration. The methanol is eliminated under reduced pressure and an additional addition of diethyl ether allows crystallization of the expected product (3.6 g; yield=60%). 
     NMR  1 H (DMSO D6, 100 MHz, δ): 8.09 (s, 1H); 7.98 (d, 1H, J=6.6 Hz); 7.75 (d, 1H, J=8.4 Hz); 7.58 (t, 1H, J=8.4 Hz); 7.4 (t, 1H, J=7 Hz); 4.83 (s, 2H, CH 2 Br). 
     Preparations 8–12 
     The following compounds were prepared in a similar fashion to the procedure described in Preparation 12: 
     
       
         
         
             
             
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
               
               
                   
                   
                 Duration 
                   
               
               
                 Prep. 
                 R3 
                 of reaction (hrs) 
                 Yield (%) 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 13* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8 
                 78 
               
               
                   
               
               
                 14* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2 
                 62 
               
               
                   
               
               
                 15* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 10 
                 56 
               
               
                   
               
               
                 16* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 2 
                 53 
               
               
                   
               
               
                 17* 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3 
                 95 
               
               
                   
               
               
                 18  
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 8 
                 27 
               
               
                   
               
               
                 *Compound already described in the literature. 
               
            
           
         
       
     
     II) Synthesis of 2-arylimino-2,3-dihydrothiazoles via synthesis on solid phase 
     Preparation of Wang Resin p-nitrophenylcarbonate 
     
       
         
         
             
             
         
       
     
     This resin was prepared from Wang resin, acquired from Bachem or Novabiochem with a load greater than 0.89 mmol/g, by a well described general procedure (cf. Bunin, B. A.  The Combinatorial Index , Academic Press, 1998, p. 62–63; Dressman, B. A.; Spangle, L. A.; Kaldor, S. W.  Tetrahedron Lett.  1996, 37, 937–940; Hauske, J. R.; Dorff, P.  Tetrahedron Lett.  1995, 36, 1589–1592; Cao, J.; Cuny, G. D.; Hauske, J. R.  Molecular Diversity  1998, 3, 173–179): N-methylmorpholine or pyridine as base and 4-nitrophenylchloroformate are successively added to a Wang resin pre-swollen in dichloromethane (DCM) or tetrahydrofuran (THE) at ambient temperature. The mixture is agitated overnight. The resin is then washed successively with THF, diethyl ether and DCM then dried overnight under reduced pressure at 50° C. 
     Method A 
     Preparation of Monoprotected Symmetrical Diamines 
     
       
         
         
             
             
         
       
     
     General procedure: as already described in the literature (Dixit, D. M.; Leznoff, C. C.  J. C. S. Chem. Comm.  1977, 798–799; Dixit, D. M.; Leznoff, C. C.  Israel J. Chem.  1978, 17, 248–252; Kaljuste K.; Unden, A.  Tetrahedron Lett.  1995, 36, 9211–9214; Munson, M. C.; Cook, A. W.; Josey, J. A.; Rao, C.  Tetrahedron Lett.  1998, 39, 7223–7226), a Wang resin p-nitrophenylcarbonate is treated with a large excess of symmetrical diamine (10–20 equivalents), in an aprotic solvent such as DCM or DMF, in order to produce a monoprotected diamine resin after agitation overnight. 
     Preparation of Thiourea Resins 
     
       
         
         
             
             
         
       
     
     General procedure: aromatic and heteroaromatic isothiocyanates (5–10 equivalents) are added (Smith, J.; Liras, J. L.; Schneider, S. E.; Anslyn, E. V.  J. Org. Chem.  1996, 61, 8811–8818) to monoprotected symmetrical diamines in a solvent such as DCM or DMF agitated overnight at ambient temperature. Washed successively with DMF and DCM, the thiourea resin is isolated then dried overnight under reduced pressure at 50° C. 
     Preparation 19 
     (phenylaminothioyl)ethyl Wang resin carbamate 
     
       
         
         
             
             
         
       
     
     Phenylisothiocyanate (1 ml; 8.5 mmol; 5 eq.) is added to an ethylene diamine Wang resin N-carbamate (2 g; 1.72 mmol; 0.86 mmol/g) swollen in DCM (50 ml). After agitation overnight at ambient temperature, the resin is washed successively with DMF (5×20 ml) and DCM (5×20 ml). The success of the coupling is monitored using the Kaiser ninhydrin test (Kaiser, E.; Colescott, R. L.; Bossinger, C. D.; Cook, P. I.  Anal. Biochem.  1970, 34, 595–598). A pale yellow resin (1.79 g) is obtained with a load of 0.648 mmol/g calculated from the elemental analysis of sulphur. 
     Synthesis of 2-arylimino-2,3-dihydrothiazoles 
     
       
         
         
             
             
         
       
     
     General procedure: regioselective cyclization stage (Korohoda, M. J.; Bojarska, A. B.  Polish J. Chem.  1984, 58, 447–453; Ragab, F. A.; Hussein, M. M.; Hanna, M. M.; Hassan, G. S.; Kenawy, S. A.  Egypt. J. Pharm. Sci.  1993, 34, 387–400; Hassan, H. Y.; El-Koussi, N. A.; Farghaly, Z. S.  Chem. Pharm. Bull.  1998, 46, 863–866) takes place in aprotic solvents such as dioxane or DMF at 80° C. for 2–3 hours between the thiourea resin and the α-bromoketone (2–5 equivalents). The resin is then washed successively with DMF, methanol and DCM then dried under reduced pressure. The 2-arylimino-2,3-dihydrothiazole resin is cleaved under acid conditions (DCM/trifluoroacetic acid at 50%) for 1–2 hours then rinsed with DCM. The solvent is evaporated off and the free base is isolated after treatment under basic conditions (saturated solution of sodium hydrogen carbonate), extraction with DCM or elution with methanol in a basic alumina cartridge (500 mg, Interchim). 
    
    
     EXAMPLE 1 
     N-[3-(2-aminoethyl)-4-(4-chlorophenyl)-1,3-thiazol-2(3H)-ylidene]aniline 
     (C 17 H 16 ClN 3 S, MM=29.86) 
     
       
         
         
             
             
         
       
     
     2-bromo-4′-chloroacetophenone (30.2 mg; 129 μmol; 2 eq.) dissolved in DMF (1 ml) is added to a thiourea resin prepared above (100 mg; 64.8 μmol; load of 0.648 mmol/g). The mixture is agitated for 2 hours at 80° C. The resin is then successively washed with DMF (3×2 ml), methanol (3×2 ml) and DCM (3×2 ml). The release stage, carried out in 1 ml of a mixture of DCM/trifluoroacetic acid at 50%, produces an oil after one hour 30 minutes of agitation which is eluted with methanol in a basic alumina cartridge (500 mg, Interchim). The free base is isolated in a quantitative fashion (21.3 mg) in the form of a yellow oil having a purity measured by UV spectrophotometry of 98% at 220 nm. 
     NMR  1 H (DMSO D6, 100 MHz) δ: 7.55 (s, 5H); 7.3 (d, 2H, J=7.1 Hz); 6.99 (d, 2H, J=7.1 Hz); 6.21 (s, 1H, H azole); 3.74 (t, 2H, J=6.2 Hz, NCH 2 ); 3.32 (broad s, 2H, NH 2 ); 2.72 (t, 2H, J=6.2 Hz, NCH 2 ). SM/LC: m/z=330 (M+H) + . 
     A series of 2-arylimino-2,3-dihydrothiazoles was synthesized according to method A using our robotic system (ACT MOS 496): 
     R1 groups: 
                         
R2 groups:
 
                                                                               
R4 represents H, alkyl, carbocyclic or heterocyclic aralkyl optionally situated on the aryl radical;
 
or then the
 
                         
radical represents a radical of general formula
 
                         
in which i represents an integer from 1 to 3;
 
it being understood that for R4, when the aryl group is substituted, it can be 1 to 5 times (other than the bond which links it to the remainder of the molecule) by radicals chosen independently from the group composed of a halogen atom and an alkyl or alkoxy radical.
 
Method B
 
     Preparation of Wang Resin Carbamates from aminoalkylanilines 
     
       
         
         
             
             
         
       
     
     General procedure: as already described (Hulme, C.; Peng, J.; Morton, G.; Salvino, J. M.; Herpin, T.; Labaudiniere, R.  Tetrahedron Lett.  1998, 39, 7227–7230), a p-nitrophenylcarbonate Wang resin is treated with an excess of aminoalkylaniline (5–10 eq.) in DCM or DMF and agitated at ambient temperature overnight. The resin is washed successively with DMF, methanol and DCM then dried overnight under reduced pressure at 50° C. 
     Preparation 20 
     4-aminophenylethyl Wang Resin Carbamate 
     
       
         
         
             
             
         
       
     
     A solution of 2-(4-aminophenyl)ethylamine (2.48 g; 17.3 mmol; 5 eq.) in 30 ml of anhydrous DMF is added to a Wang resin p-nitrophenylcarbonate (4.05 g; 3.47 mmol; load of 0.857 mmol/g) pre-swollen in 50 ml of anhydrous DMF. The mixture is agitated at ambient temperature overnight and filtered. The resin is washed successively with DMF (10×30 ml), methanol (5×30 ml) and DCM (5×30 ml). 3.7 g of yellow resin (load of 0.8 mmol/g calculated from the elemental analysis of the nitrogen), giving a positive Kaiser ninhydrin test, is isolated after drying overnight under reduced pressure at 50° C. 
     Preparation of Thiourea Resins with aliphatic isothiocyanates 
     
       
         
         
             
             
         
       
     
     General procedure: aliphatic isothiocyanates (5–10 equivalents) are added to an aminoalkylaniline resin in a solvent such as DCM or DMF and agitation is carried out overnight at ambient temperature. After washing Successively with DMF and DCM, the thiourea resin is isolated and dried overnight under reduced pressure at 50° C. 
     Preparation 21 
     4-{([(phenylethylamino)carbothioyi]amino}-phenylethyl Wang resin carbamate 
     
       
         
         
             
             
         
       
     
     10 ml of anhydrous DMF and phenylethylisothiocyanate (624 μl, 4 mmol, 10 eq.) are added under an argon atmosphere to the resin described previously (0.5 g; 0.4 mmol; load of 0.8 mmol/g). The reaction medium is agitated overnight at ambient temperature and produces a negative Kaiser ninhydrin test. The resin is then washed successively with DMF (5×20 ml) and DCM (5×20 ml). Drying under reduced pressure at 50° C. produces 488 mg of resin with a load of 0.629 mmol/g calculated from elemental analysis of the sulphur. 
     Synthesis of 2-arylimino-2,3-dihydrothiazoles 
     
       
         
         
             
             
         
       
     
     General procedure: the cyclization stage takes place in aprotic solvents such as dioxane or DMF at 80° C. for 2 hours between the thiourea resin and the α-bromoketone (2–5 equivalents). The resin is then washed successively with DMF, methanol and DCM then dried under reduced pressure. The iminothiazole resin is cleaved by treatment under acid conditions (DCM/trifluoroacetic acid at 50%) for 1–2 hours then rinsed with DCM. The solvent is evaporated off and the free base isolated after extraction under basic conditions (saturated solution of sodium hydrogen carbonate), extraction with DCM or elution with methanol in a basic alumina cartridge (500 mg, Interchim). 
     EXAMPLE 2 
     4-(2-aminoethyl)-N-[4-(4-chlorophenyl)-3-phenethyl-1,3-thiazol-2(3H)-ylidene]aniline 
     (C 25 H 24 ClN 3 S, MM=434.01) 
     
       
         
         
             
             
         
       
     
     100 mg (62.9 μmol, load of 0.629 mmol/g) of thiourea resin and 2-bromo-4′-chloroacetophenone (30 mg; 125.8 μmol; 2 eq.) are dissolved in 1 ml of DMF and heated to 80° C. for 2 hours. The resin is then washed successively with DMF (5×1 ml), methanol (5×1 ml) and DCM (5×1 ml). The resin is agitated in 1 ml of a DCM/trifluoroacetic acid mixture at 50% for one hour and 30 minutes at ambient temperature. The resin is rinsed with DCM (5×1 ml) and the filtrate evaporated under reduced pressure. The residue, dissolved in methanol, is eluted in a basic alumina cartridge (500 mg, Interchim) in order to quantitatively produce (27.3 mg) the expected product in the form of a solid (UV purity: 97% at 220 nm). 
     NMR  1 H (DMSO D6, 100 MHz) δ: 7.9 (broad s, 2H, NH 2 ); 7.53 (d, 2H, J=8.5 Hz); 7.32–7.15 (m, 7H); 7.08–6.9 (m, 4H); 6.37 (s, 1H, H azole); 4.07 (m, 2H; NCH 2 ); 3.03 (m, 2H, NCH 2 ); 2.88 (m, 4H). MS/LC: m/z=435 (M+H) + . 
     A series of 2-arylimino-2,3-dihydrothiazoles was synthesized according to method B with our robotic system (ACT MOS 496): 
     R1 groups 
                                                             
Method C
 
     Synthesis of 2-arylimino-1,3-thiazole-4(3H)-carboxamides 
     
       
         
         
             
             
         
       
     
     General procedure: a regioselective cyclization stage using α-bromopyruvic acid (2–5 eq.) is carried out starting from the thiourea resin prepared in the method A in aprotic solvents such as dioxane or DMF at 80° C. for 2–3 hours. The resin is then washed successively with DMF, methanol and DCM then dried under reduced pressure. The peptide coupling (Knorr, R.; Trzeciak, A.; Bannwarth, W.; Gillessen, D.  Tetrahedron Lett.  989, 30, 1927–1930) takes place in DMF at ambient temperature for 1–24 hours with different standard coupling agents (4–5 eq.) such as dicyclohexylcarbodiimide (DCC), diisopropylcarbodiimide (DIC), a DIC/N-hydroxybenzotriazole (HOBt) mixture, benzotriazolyloxytris(dimethylamino)phosphonium hexafluorophosphate (PyBOP), 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) or 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) and aminated compounds (4–5 eq.). The 2-arylimino-1,3-thiazole-4 (3H)-carboxamide resin is cleaved by treatment under acid conditions (DCM/trifluoroacetic acid at 50%) for 1–2 hours then rinsed with DCM. The solvent is evaporated off and the free base is isolated after treatment under basic conditions (saturated solution of sodium hydrogen carbonate), extraction is carried out with DCM or elution with methanol in a basic alumina cartridge (500 mg, Interchim). 
     EXAMPLE 3 
     3-(4-aminobutyl)-N-benzhydryl-2-[(4-bromophenyl)imino]-1,3-thiazole-4(3H)-carboxamide 
     (C 27 H 27 BrN 4 OS, MM=535.51) 
     
       
         
         
             
             
         
       
     
     50 mg (27.5 μmol, load of 0.55 mmol/g) of carboxylic acid resin is activated for 15 minutes with 14.8 mg (0.11 mmol, 4 eq.) of N-hydroxybenzotriazole and 35.3 mg (0.11 mmol, 4 eq.) of TBTU in 800 μl of anhydrous DMF. 20.7 mg (0.11 mmol, 4 eq.) of aminodiphenylmethane dissolved in 200 μl of anhydrous DMF is then added and the resin is filtered after agitation overnight at ambient temperature. A sequential washing with DMF (5×1 ml), methanol (5×1 ml) and DCM (5×1 ml) produces a resin which is treated for one hour and 30 minutes under acid conditions (DCM/trifluoroacetic acid at 50%). The resin is rinsed with DCM (5×1 ml) and the filtrate evaporated under reduced pressure. The residue, taken up in methanol, is eluted in a basic alumina cartridge (500 mg, Interchim) in order to produce a pale yellow solid (8.2 mg; yield of 55.7%; UV purity of 94% at 220 nm). 
     NMR  1 H (DMSO D6, 100 MHz, δ): 9.6 (d; 1H; J=8.6 Hz; NH); 7.49 (d; 2H; J=8.6 Hz); 7.35 (s; 10H); 6.92 (s; 1H; H azole); 6.91 (d; 2H; J=8.5 Hz); 6.27 (d; 1H; J=8.5 Hz; NHCH); 4.02 (m; 2H; NCH 2 ); 3.45 (broad m; 2H+2H; NH 2  and NCH 2 ); 1.55–1.24 (broad m; 4H). MS/LC: m/z=535 (M+H). 
     A series of 2-arylimino-1,3-thiazole-4(3H)-carboxamides was synthesized according to method C using our robotic system (ACT MOS 496): 
     R1 and R2 groups already described in method A; 
     R3=—CO-R5; 
     R4=H; 
     R5 groups 
                                                                                                                                                                                                             
Method D
 
     Synthesis of 2-arylimino-1,3-thiazole-4(3H)-carboxamides 
     
       
         
         
             
             
         
       
     
     General procedure: a regioselective cyclization stage using α-bromopyruvic acid (2–5 eq.) is carried out starting from the thiourea resin prepared in method B in aprotic solvents such as dioxane or DMF at 80° C. for 2–3 hours. The resin is then successively washed with DMF, methanol and DCM then dried under reduced pressure. The peptide coupling (Knorr, R.; Trzeciak, A.; Bannwarth, W.; Gillessen, D.  Tetrahedron Lett.  1989, 30, 1927–1930) takes place in DMF at ambient temperature for 1–24 hours with different standard coupling agents (4–5 eq.) such as dicyclohexylcarbodiimide (DCC), diisopropylcarbodiimide (DIC), a DIC/N-hydroxybenzotriazole (HOBt) mixture, benzotriazolyloxytris(dimethylamino)phosphonium hexafluorophosphate (PyBOP), 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) or 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU) and aminated compounds (4–5 eq.). The 2-arylimino-1,3-thiazole-4(3H)-carboxamide resin is cleaved by treatment under acid conditions (DCM/trifluoroacetic acid at 50%) for 1–2 hours then rinsed with DCM. The solvent is evaporated off and the free base is isolated after treatment under basic conditions (saturated solution of sodium hydrogen carbonate) followed by an extraction with DCM or elution with methanol in a basic alumina cartridge (500 mg, Interchim). 
     EXAMPLE 4 
     (2Z)-2-{[4-(2-aminoethyl)phenyl]inlino}-N-(4-chlorobenzyl)-3-(2-phenylethyl)-2,3-dihydro-1,3-thiazole-4-carboxamide 
     (C 27 H 27 ClN 4 OS, MM=491.05) 
     
       
         
         
             
             
         
       
     
     Phenylethylisothiocyanate (310 mg; 1.9 mmol; 10 eq.) in 3 ml of dimethylformamide is added to 200 mg (190 μmol, load of 0.946 mmol/g) of aminated resin (see Preparation 20). Agitation overnight at ambient temperature produces a negative Kaiser ninhydrin test. The resin is then successively washed with DMF (5×3 ml) and DCM (5×3 ml) then dried under vacuum for one hour before adding bromopyruvic acid (63.4 mg; 380 μmol; 2 eq.) diluted beforehand in 3 ml of dimethylformamide. The mixture is agitated for 2.5 hours at 80° C. The resin is filtered and washed with DMF (5×3 ml), methanol (3×3 ml) then DCM (5×3 ml). The carboxylic acid resin is preactivated for 1 hour with 244 mg (0.76 mmol; 4 eq.) of TBTU diluted in 2 ml of anhydrous DMF. 110 mg (0.76 mmol; 4 eq.) of 4-chlorobenzylamine dissolved in 1 ml of anhydrous DMF is then added and the resin is filtered after agitation overnight at ambient temperature. Sequential washing with DMF (5×3 ml), methanol (3×3 ml) and DCM (3×3 ml) produces a resin which is treated for one hour and 30 minutes under acid conditions (DCM/trifluoroacetic acid at 50%). The resin is rinsed with DCM (5×1 ml) and the filtrate evaporated under reduced pressure. The residue, taken up in DCM, is neutralized with a saturated solution of sodium hydrogen carbonate in order to produce after evaporation a solid (38.2 mg; yield of 41%; UV purity of 90% at 210 nm). NMR  1 H (DMSO D6, 400 MHz, δ): 9.1 (m, 1H); 7.39 (d, 2H, J=8.4 Hz); 7.33 (d, 2H, J=8.4 Hz); 7.25 (q, 2H, J=6.8 Hz); 7.19 (q, 1H, J=7.2 Hz); 7.11 (m, 4H); 6.8 (d, 2H, J=8 Hz); 6.75 (s, 1H, H azole); 4.34 (d, 2H, J=6 Hz); 4.27 (t, 2H, J=6.8 Hz); 3.14 (m, 1H); 2.89 (t, 2H, J=6.8 Hz); 2.73 (t, 1H, J=7.2 Hz); 2.62 (m, 2H). MS/LC: m/z=491.24 (M+H) + . 
     A series of 2-arylimino-1,3-thiazole-4(3H)-carboxamides was synthesized according to method D using our robotic system (ACT MOS 496): 
     R1 and R2 groups already described in method B 
     R3=—CO-R5 
     R4=H 
     R5 groups already described in method C. 
     Method E 
     Preparation of Monoprotected Diamine Resin Functionalized with α-bromopyruvic Acid 
     
       
         
         
             
             
         
       
     
     General procedure: the monoprotected symmetrical primary or secondary diamine resin (the preparation of which is already described in method A) is functionalized by peptide coupling with α-bromopyruvic acid (10 eq.), DIC (10 eq.) and HOBt (10 eq.) in a solvent such as DMF at ambient temperature. The resin is washed successively with DMF then with DCM after 2 to 24 hours of agitation before being dried under vacuum. The negative Kaiser ninhydrin test indicates a complete functionalization. 
     Preparation 22 
     N-carbamate of 2-[(3-bromo-2-oxopropanoyl)amino]ethyl Wang resin 
     
       
         
         
             
             
         
       
     
     HOBt (0.93 g, 6.88 mmol) and α-bromopyruvic acid (1.18 g, 6.88 mmol) are dissolved in 28 ml of DMF (0.5 M). DIC (1.07 ml; 6.88 mmol) is then added by syringe to activate the acid. The mixture is agitated for approximately 15 minutes at ambient temperature before adding it to the ethylene diamine Wang resin N-carbamate (0.8 g; 0.688 mmol; load rate 0.86 mmol/g). After agitation for 3 hours at ambient temperature, the Kaiser ninhydrin test being negative, the resin is filtered and washed successively with DMF (5×20 ml) then with DCM (5×20 ml) before being dried under vacuum. An ochre resin (0.812 g) is obtained with a load rate of 0.525 mmol/g calculated from elemental analysis of the bromine. 
     Synthesis of 2-arylimino-1,3-thiazole-4(3H)-carboxamides 
     
       
         
         
             
             
         
       
     
     General procedure: formation of the thiourea is carried out in a solvent such as DMF or dioxane by mixing an equimolar quantity of primary amine and aromatic or heteroaromatic isothiocyanate. After agitation for 2 to 24 hours at ambient temperature, the thiourea (2 to 5 eq.) is added to the functionalized resin then heated at 80° C. for 2 to 4 hours. The 2-arylimino-1,3-thiazole-4(3H)-carboxamide resin is cleaved by treatment under acid conditions (DCM/trifluoroacetic acid at 50%) for 1–2 hours then rinsing with DCM. The solvent is evaporated off and the free base isolated after treatment under basic conditions (saturated solution of sodium hydrogen carbonate), extraction with DCM or elution with methanol in a basic alumina cartridge (500 mg, Interchim). 
     EXAMPLE 5 
     (2Z)-N-(2-aminoethyl)-3-[2-(3,4-dimethoxyphenyl)ethyl]-2-(phenylimino)-2,3-dihydro-1,3-thiazole-4-carboxamide 
     (C 22 H 26 N 4 O 3 S, MM=426.54) 
     
       
         
         
             
             
         
       
     
     18 μl (105 μmol; 2 eq.) of β-(3,4-dimethoxyphenyl)ethylamine and 12.6 μl (105 μmol; 2 eq.) of phenylisothiocyanate are agitated in 1 ml of DMF for 18 hours. The thiourea is added to 100 mg (52.5 μmol; load rate of 0.525 mmol/g) of resin (Preparation 22) and the mixture heated at 80° C. for 3 hours. The resin is then filtered then washed successively with DMF (5×1 ml), methanol (5×1 ml) then DCM (5×1 ml). The resin is dried under vacuum before adding 1 ml of a 50% DCM/TFA mixture. Agitation is carried out for 1.5 hours at ambient temperature, the resin is filtered and rinsed with DCM. The residue recovered after evaporation is then eluted with methanol in a basic alumina cartridge in order to isolate 22.2 mg (quantitative yield; UV purity of 93.4% at 230 nm) of a brown solid corresponding to the free amine. 
     NMR  1 H (DMSO D6, 100 MHz, δ): 8.42 (m, 1H, NH); 7.32 (t, 2H, J=7.1 Hz); 7.08–6.63 (m, 6H); 5.76 (s, 1H, H azole); 4.31 (t, 2H, J=6.6 Hz); 3.72 (s, 6H, OCH 3 ); 3.32 (broad s, 2H); 3.17 (m, 2H); 2.89 (m, 2H); 2.62 (m, 2H). MS/LC: m/z=427.17 (M+H) + . 
     A series of 2-arylimino-1,3-thiazole-4(3H)-carboxamides was synthesized according to method E using our robotic system (ACT MOS 496): 
     R1 groups: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     R2 groups already described in method A 
     R3=—CO-R5 
     R4=H 
     R5 groups: 
                         
Method F
 
     Preparation of monoprotected diamine resins functionalized with N-protected amino acids (Fmoc) 
     
       
         
         
             
             
         
       
     
     General procedure: the peptide coupling of the monoprotected diamine resins with N-Fmoc amino acids (4 to 10 eq.) which are commercially available (Bunin, B. A.  The Combinatorial Index, Academic Press,  1998, p. 77–82) is carried out in DMF at ambient temperature for 1 to 24 hours with different standard coupling agents (4 to 10 eq.) such as dicyclohexylcarbodiimide (DCC), diisopropylcarbodiimide (DIC), a DIC/N-hydroxybenzotriazole (HOBt) mixture, benzotriazolyloxytris(dimethylamino) phosphonium hexafluorophosphate (PyBOP), 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HBTU) or 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium tetrafluoroborate (TBTU). The resin is then washed successively with DMF and DCM. The coupling sequence can be repeated (once or twice) until the Kaiser ninhydrin test is negative. 
     Preparation 23 
     4-[({[(9H-fluoren-9-ylmethoxy)carbonyl]amino}acetyl)amino]butyl N-carbamate 
     
       
         
         
             
             
         
       
     
     Fmoc-Gly-OH acid (2.36 g, 7.94 mmol) is activated with HOBt (1.07% g, 7.94 mmol) and DIC (1.25 ml, 7.94 mmol) in 22 ml of DMF for 5 minutes before adding the mixture to butylamine Wang resin N-carbamate (1 g, load rate of 0.794 mmol/g) preswollen in 10 ml of DMF. After agitation for 18 hours at ambient temperature, the resin is washed successively with DMF (5×20 ml) then with DCM (5×20 ml) before being dried under vacuum. 1.27 g of pale yellow resin is thus obtained presenting a negative Kaiser ninhydrin test.
         Preparation of the thiourea resins       

     
       
         
         
             
             
         
       
     
     General procedure: a resin described above is deprotected with a 20% DMF/piperidine mixture. After agitation for one hour at ambient temperature, the resin is filtered and washed successively with DMF then with DCM. The deprotection/washing sequence is repeated a second time and the resin is dried under vacuum. The latter is preswollen in a solvent such as DMF or DCM then an aromatic or heteroaromatic isothiocyanate (5 to 10 eq.) is added. The mixture is agitated for 2 to 24 hours at ambient temperature before the resin is filtered and washed successively with DMF then with DCM. The resin is then dried under vacuum and a negative Kaiser ninhydrin test confirms that the substitution reaction is complete. 
     Preparation 24 
     4-[({[(1-naphthylamino)carbothioyl]amino}acetyl)amino]butyl Wang resin N-carbamate 
     
       
         
         
             
             
         
       
     
     1.27 g of the above resin (see Preparation 23) is deprotected with 14 ml of DMF/piperidine at 20%. The mixture is agitated for one hour at ambient temperature. The resin is then filtered then washed with DMF (5×30 ml) then with DCM (5×30 ml). The deprotection/washing sequence is repeated once before the resin is dried under vacuum. 0.781 g of pale yellow resin was thus obtained with a load rate of 0.758 mmol/g calculated after elemental analysis of the sulphur. 416 mg (2.2 mmol, 10 eq.) of 1-naphthylisothiocyanate diluted in 6 ml of DMF is added to 0.3 g (0.22 mmol) of this thiourea resin. The mixture is agitated for 18 hours at ambient temperature. The resin is filtered then washed successively with DMF (5×20 ml) then with DCM (5×20 ml). 310 mg of a pale yellow resin is isolated after drying under vacuum with a load rate of 0.66 mmol/g calculated after elemental analysis of the nitrogen. 
     Synthesis of 2-arylimino-2,3-dihydrothiazoles 
     
       
         
         
             
             
         
       
     
     General procedure: the regioselective cyclization stage is carried out in aprotic solvents such as dioxane, DMF or N-methylpyrrolidinone at 80° C. for 2 to 3 hours between the thiourea resin and the α-bromoketone (2 to 5 eq.). The resin is then washed successively with DMF, methanol and DCM then dried under reduced pressure. The 2-arylimino-2,3-dihydrothiazole resin is cleaved under acid conditions (DCM/trifluoroacetic acid at 50%) for 1 to 2 hours then rinsed with DCM. The solvent is evaporated off and the free base isolated after treatment under basic conditions (saturated solution of sodium hydrogen carbonate) followed by an extraction with DCM or elution with methanol in a basic alumina cartridge (500 mg, Interchim). 
     EXAMPLE 6 
     N-(4-aminobutyl)-2-((2Z)-4-(4-chlorophenyl)-2-(1-naphthylimino)-1,3-thiazol-3(2H)-yl)acetamide 
     (C 25 H 25 ClN 4 OS, MM=465.02) 
     
       
         
         
             
             
         
       
     
     80 mg (52.8 μmol, load rate of 0.66 mmol/g) of thiourea resin (Preparation 24) and 25.1 mg (105.6 mmol, 2 eq.) of 2-bromo-4′-chloroacetophenone are diluted in 1 ml of DMF. The mixture is heated at 80° C. for 2 hours. The resin is filtered then washed with DMF (5×1 ml), methanol (5×1 ml) then DCM (5×1 ml) before being dried under vacuum. 1 ml of a 50% DCM/TFA mixture is added followed by agitation for 1 hour 30 minutes. The resin is filtered and rinsed with DCM. The filtrate is evaporated then rediluted in methanol for elution on basic alumina. 20.6 mg (yield of 84%; UV purity of 94.2% at 220 mm) of yellow solid is thus isolated after evaporation corresponding to the free base. 
     NMR  1 H (DMSO D6, 100 MHz, δ): 8.36 (t, 1H, J=4.7 Hz, NH); 8.12 (dd, 1H, J=2.1 and 7.3 Hz); 7.87 (dd, 1H, J=2.7 and 6.3 Hz); 7.63–7.34 (m, 8H); 7.13 (dd, 1H, J=1.6 and 6.7 Hz); 6.33 (s, 1H, H azole); 4.44 (broad s, 2H); 3.14 (m, 2H); 2.7 (m, 2H); 1.5 (m, 4H). MS/LC: m/z=465.21 (M+H) + . 
     A series of 2-arylimino-2,3-dihydrothiazoles was synthesized according to method F using our robotic system (ACT MOS 496): 
     R1=—C(R11R12)-CO-R10 
     R2, R3 and R4 groups already described in method A 
     R10 groups: 
     
       
         
         
             
             
         
       
       
         
         
             
             
         
       
       
         
         
             
             
         
       
     
     EXAMPLES 
     Examples obtained according to methods A, B, C, D, E and F described above are shown below in the tables. These examples are shown to illustrate the above processes and must not in any circumstances be considered as limiting the scope of the invention. 
     The compounds obtained have been characterized by their retention times (rt) and by mass spectrometry (M+H) + . 
     The chromatograms are obtained from a high performance liquid chromatography device (Hewlett-Packard 1100) equipped with a scanning UV detector. The following conditions were used to measure the retention times by high performance liquid chromatography, it being understood that the extraction wavelength of each of the chromatograms is 220 nm: 
     
       
         
           
               
               
               
             
               
                   
               
               
                 t (min.) 
                 A (%) 
                 B (%) 
               
               
                   
               
             
            
               
                 0 
                 90 
                 10 
               
               
                 6 
                 15 
                 85 
               
               
                 8 
                 15 
                 85 
               
               
                   
               
               
                 Eluent A: water + 0.02% trifluoroacetic acid; eluent B: acetonitrile. 
               
               
                 Flow rate: 1 ml/min; volume injected: 5 μl; temperature: 40° C. 
               
               
                 Column: Uptisphere 3 μm ODS, 50 × 4.6 mm i.d. (Interchim) 
               
            
           
         
       
     
     The mass spectra are obtained from a single quadrupole mass spectrometer equipped with an electrospray source (Micromass, Platform II). 
     
       
         
           
               
             
               
                   
               
             
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R3 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                   7 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.2 
                 3.09 
                 304.2 
               
               
                   
               
               
                   8 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.1 
                 3.38 
                 338.2 
               
               
                   
               
               
                   9 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 3.56 
                 352.2 
               
               
                   
               
               
                  10 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.3 
                 3.42 
                 338.2 
               
               
                   
               
               
                  11 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.6 
                 3.25 
                 342.2 
               
               
                   
               
               
                  12 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.4 
                 3.46 
                 365.2 
               
               
                   
               
               
                  13 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.9 
                 3.86 
                 393.2 
               
               
                   
               
               
                  14 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.4 
                 3.44 
                 358.2 
               
               
                   
               
               
                  15 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.6 
                 3.34 
                 382.2 
               
               
                   
               
               
                  16 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.5 
                 3.7 
                 408 
               
               
                   
               
               
                  17 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54.43 
                 2.9 
                 305.2 
               
               
                   
               
               
                  18 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 50.4 
                 3.14 
                 339.2 
               
               
                   
               
               
                  19 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 48.9 
                 3.38 
                 535.2 
               
               
                   
               
               
                  20 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 39.3 
                 3.26 
                 339.2 
               
               
                   
               
               
                  21 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 49.5 
                 3.06 
                 343.2 
               
               
                   
               
               
                  22 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 42.3 
                 3.29 
                 366.2 
               
               
                   
               
               
                  23 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 43.4 
                 3.7 
                 394.3 
               
               
                   
               
               
                  24 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56.7 
                 3.16 
                 359.2 
               
               
                   
               
               
                  25 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 45.3 
                 3.09 
                 383.2 
               
               
                   
               
               
                  26 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 45.7 
                 3.3 
                 409 
               
               
                   
               
               
                  27 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.8 
                 3.41 
                 332.3 
               
               
                   
               
               
                  28 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 3.7 
                 366.3 
               
               
                   
               
               
                  29 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.6 
                 3.84 
                 380.3 
               
               
                   
               
               
                  30 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.7 
                 3.76 
                 366.3 
               
               
                   
               
               
                  31 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.4 
                 3.63 
                 370.2 
               
               
                   
               
               
                  32 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.1 
                 3.82 
                 393.2 
               
               
                   
               
               
                  33 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.1 
                 4.12 
                 410.2 
               
               
                   
               
               
                  34 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.7 
                 3.83 
                 386.2 
               
               
                   
               
               
                  35 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.8 
                 3.67 
                 410.2 
               
               
                   
               
               
                  36 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.4 
                 4.17 
                 436.1 
               
               
                   
               
               
                  37 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.4 
                 3.64 
                 329.25 
               
               
                   
               
               
                  38 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.8 
                 4.03 
                 363.2 
               
               
                   
               
               
                  39 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.6 
                 4.15 
                 377.2 
               
               
                   
               
               
                  40 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.1 
                 4.22 
                 363.2 
               
               
                   
               
               
                  41 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.2 
                 4.1 
                 376.2 
               
               
                   
               
               
                  42 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 4.35 
                 390.2 
               
               
                   
               
               
                  43 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.1 
                 4.54 
                 418.2 
               
               
                   
               
               
                  44 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 4.34 
                 383.1 
               
               
                   
               
               
                  45 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.1 
                 4.06 
                 407.2 
               
               
                   
               
               
                  46 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 4.7 
                 433.1 
               
               
                   
               
               
                  47 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.4 
                 3.32 
                 332.3 
               
               
                   
               
               
                  48 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.9 
                 3.62 
                 366.3 
               
               
                   
               
               
                  49 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.6 
                 3.76 
                 380.3 
               
               
                   
               
               
                  50 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.6 
                 3.64 
                 366.33 
               
               
                   
               
               
                  51 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 3.51 
                 370.2 
               
               
                   
               
               
                  52 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87 
                 3.69 
                 390.2 
               
               
                   
               
               
                  53 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.9 
                 4.04 
                 421.3 
               
               
                   
               
               
                  54 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.1 
                 3.7 
                 436.1 
               
               
                   
               
               
                  55 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.6 
                 3.59 
                 410.2 
               
               
                   
               
               
                  56 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.6 
                 3.92 
                 436.1 
               
               
                   
               
               
                  57 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.1 
                 3.66 
                 368.2 
               
               
                   
               
               
                  58 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.7 
                 3.94 
                 402.2 
               
               
                   
               
               
                  59 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.5 
                 4.06 
                 416.2 
               
               
                   
               
               
                  60 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.4 
                 4.09 
                 402.2 
               
               
                   
               
               
                  61 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.1 
                 3.99 
                 406.2 
               
               
                   
               
               
                  62 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.6 
                 4.21 
                 429.2 
               
               
                   
               
               
                  63 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.6 
                 4.39 
                 457.2 
               
               
                   
               
               
                  64 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.22 
                 422.1 
               
               
                   
               
               
                  65 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.6 
                 3.96 
                 446.2 
               
               
                   
               
               
                  66 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.5 
                 4.65 
                 472 
               
               
                   
               
               
                  67 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 3.07 
                 348.2 
               
               
                   
               
               
                  68 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.6 
                 3.36 
                 382.2 
               
               
                   
               
               
                  69 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.4 
                 3.54 
                 396.2 
               
               
                   
               
               
                  70 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.7 
                 3.41 
                 382.1 
               
               
                   
               
               
                  71 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.3 
                 3.24 
                 386.2 
               
               
                   
               
               
                  72 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.5 
                 3.44 
                 409.1 
               
               
                   
               
               
                  73 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.4 
                 3.83 
                 437.2 
               
               
                   
               
               
                  74 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.4 
                 3.41 
                 402.1 
               
               
                   
               
               
                  75 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.7 
                 3.32 
                 426.2 
               
               
                   
               
               
                  76 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.4 
                 3.64 
                 452.2 
               
               
                   
               
               
                  77 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.1 
                 3.66 
                 324.2 
               
               
                   
               
               
                  78 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.2 
                 3.98 
                 388.2 
               
               
                   
               
               
                  79 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.9 
                 4.09 
                 402.2 
               
               
                   
               
               
                  80 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.1 
                 4.12 
                 388.2 
               
               
                   
               
               
                  81 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.1 
                 4.03 
                 392.2 
               
               
                   
               
               
                  82 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.2 
                 4.24 
                 415.2 
               
               
                   
               
               
                  83 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.3 
                 4.39 
                 443.3 
               
               
                   
               
               
                  84 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.3 
                 4.28 
                 408.1 
               
               
                   
               
               
                  85 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.2 
                 4.0 
                 432.2 
               
               
                   
               
               
                  86 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.6 
                 4.7 
                 458.1 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R3 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                  87 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 3.35 
                 338.2 
               
               
                   
               
               
                  88 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 3.51 
                 352.3 
               
               
                   
               
               
                  89 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 3.58 
                 352.3 
               
               
                   
               
               
                  90 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 3.42 
                 356.2 
               
               
                   
               
               
                  91 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86 
                 4.01 
                 422.2 
               
               
                   
               
               
                  92 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 3.99 
                 407.3 
               
               
                   
               
               
                  93 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 7 
                 3.65 
                 391.3 
               
               
                   
               
               
                  94 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 4.11 
                 378.2 
               
               
                   
               
               
                  95 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 3.43 
                 435.2 
               
               
                   
               
               
                  96 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 3.91 
                 422.1 
               
               
                   
               
               
                  97 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 43 
                 3.19 
                 339.2 
               
               
                   
               
               
                  98 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 32 
                 3.33 
                 353.2 
               
               
                   
               
               
                  99 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 39 
                 3.45 
                 353.2 
               
               
                   
               
               
                  100 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 39 
                 3.28 
                 357.2 
               
               
                   
               
               
                  101 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 42 
                 3.8 
                 423.2 
               
               
                   
               
               
                  102 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 41 
                 3.89 
                 408.2 
               
               
                   
               
               
                  103 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 14 
                 3.43 
                 392.2 
               
               
                   
               
               
                  104 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 39 
                 3.62 
                 379.2 
               
               
                   
               
               
                  105 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 28 
                 3.2 
                 436.2 
               
               
                   
               
               
                  106 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35 
                 3.56 
                 423.1 
               
               
                   
               
               
                  107 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 4.65 
                 464.1 
               
               
                   
               
               
                  108 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89 
                 4.64 
                 478.2 
               
               
                   
               
               
                  109 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 4.88 
                 478.1 
               
               
                   
               
               
                  110 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 4.76 
                 482.1 
               
               
                   
               
               
                  111 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90 
                 5.41 
                 548.1 
               
               
                   
               
               
                  112 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86 
                 5.13 
                 533.2 
               
               
                   
               
               
                  113 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 9 
                 4.5 
                 517.1 
               
               
                   
               
               
                  114 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 5.49 
                 504.1 
               
               
                   
               
               
                  115 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80 
                 4.4 
                 561.1 
               
               
                   
               
               
                  116 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89 
                 5.4 
                 548.0 
               
               
                   
               
               
                  117 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.85 
                 422.2 
               
               
                   
               
               
                  118 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91 
                 4.86 
                 436.2 
               
               
                   
               
               
                  119 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88 
                 5.08 
                 436.2 
               
               
                   
               
               
                  120 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 4.96 
                 440.2 
               
               
                   
               
               
                  121 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 5.56 
                 506.2 
               
               
                   
               
               
                  122 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83 
                 5.34 
                 491.2 
               
               
                   
               
               
                  123 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 3 
                 4.7 
                 475.3 
               
               
                   
               
               
                  124 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91 
                 5.59 
                 462.2 
               
               
                   
               
               
                  125 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 4.61 
                 519.2 
               
               
                   
               
               
                  126 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 5.52 
                 506.1 
               
               
                   
               
               
                  127 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 3.63 
                 366.3 
               
               
                   
               
               
                  128 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 3.76 
                 380.3 
               
               
                   
               
               
                  129 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 3.82 
                 380.3 
               
               
                   
               
               
                  130 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 3.67 
                 384.2 
               
               
                   
               
               
                  131 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 4.16 
                 450.2 
               
               
                   
               
               
                  132 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.2 
                 435.3 
               
               
                   
               
               
                  133 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 21 
                 3.9 
                 419.3 
               
               
                   
               
               
                  134 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88 
                 4.28 
                 406.2 
               
               
                   
               
               
                  135 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 3.68 
                 463.3 
               
               
                   
               
               
                  136 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 4.09 
                 450.1 
               
               
                   
               
               
                  137 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 3.44 
                 417.2 
               
               
                   
               
               
                  138 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 3.5 
                 431.2 
               
               
                   
               
               
                  139 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 3.71 
                 431.2 
               
               
                   
               
               
                  140 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 3.58 
                 435.2 
               
               
                   
               
               
                  141 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 4.27 
                 501.2 
               
               
                   
               
               
                  142 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 4.05 
                 486.6 
               
               
                   
               
               
                  143 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 4.28 
                 457.2 
               
               
                   
               
               
                  144 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 3.39 
                 514.2 
               
               
                   
               
               
                  145 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85 
                 4.16 
                 501.1 
               
               
                   
               
               
                  146 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 3.36 
                 382.2 
               
               
                   
               
               
                  147 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 3.53 
                 396.2 
               
               
                   
               
               
                  148 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 3.6 
                 396.2 
               
               
                   
               
               
                  149 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 3.43 
                 400.2 
               
               
                   
               
               
                  150 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 3.95 
                 466.2 
               
               
                   
               
               
                  151 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 4.01 
                 451.3 
               
               
                   
               
               
                  152 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 15 
                 3.57 
                 435.2 
               
               
                   
               
               
                  153 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 4.0 
                 422.2 
               
               
                   
               
               
                  154 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 3.45 
                 479.3 
               
               
                   
               
               
                  155 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 3.84 
                 466.1 
               
               
                   
               
               
                  156 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.11 
                 388.2 
               
               
                   
               
               
                  157 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90 
                 4.14 
                 402.2 
               
               
                   
               
               
                  158 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.31 
                 402.2 
               
               
                   
               
               
                  159 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.21 
                 406.2 
               
               
                   
               
               
                  160 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 4.83 
                 472.3 
               
               
                   
               
               
                  161 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 4.57 
                 457.3 
               
               
                   
               
               
                  162 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 5.12 
                 428.2 
               
               
                   
               
               
                  163 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88 
                 4.01 
                 485.3 
               
               
                   
               
               
                  164 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 4.91 
                 472.1 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R3 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                  165 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 3.52 
                 332.3 
               
               
                   
               
               
                  166 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 99 
                 3.76 
                 370.3 
               
               
                   
               
               
                  167 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 3.9 
                 393.3 
               
               
                   
               
               
                  168 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 4.25 
                 436.2 
               
               
                   
               
               
                  169 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 4.14 
                 431.2 
               
               
                   
               
               
                  170 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 99 
                 4.79 
                 488.2 
               
               
                   
               
               
                  171 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 3.74 
                 410.2 
               
               
                   
               
               
                  172 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 4.28 
                 410.3 
               
               
                   
               
               
                  173 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 4.38 
                 392.2 
               
               
                   
               
               
                  174 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 4.73 
                 456.2 
               
               
                   
               
               
                  175 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 4.06 
                 374.3 
               
               
                   
               
               
                  176 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 4.37 
                 412.3 
               
               
                   
               
               
                  177 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 4.46 
                 435.3 
               
               
                   
               
               
                  178 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 4.8 
                 478.3 
               
               
                   
               
               
                  179 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 99 
                 4.78 
                 473.3 
               
               
                   
               
               
                  180 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 5.43 
                 530.3 
               
               
                   
               
               
                  181 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 4.27 
                 452.3 
               
               
                   
               
               
                  182 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85 
                 4.73 
                 452.4 
               
               
                   
               
               
                  183 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 5.07 
                 434.3 
               
               
                   
               
               
                  184 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 5.33 
                 498.3 
               
               
                   
               
               
                  185 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 4.61 
                 458.2 
               
               
                   
               
               
                  186 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 5.23 
                 496.1 
               
               
                   
               
               
                  187 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 5.34 
                 519.1 
               
               
                   
               
               
                  188 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 5.72 
                 562.1 
               
               
                   
               
               
                  189 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 5.57 
                 557.1 
               
               
                   
               
               
                  190 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 6.16 
                 614.1 
               
               
                   
               
               
                  191 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.97 
                 536.1 
               
               
                   
               
               
                  192 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85 
                 5.67 
                 536.2 
               
               
                   
               
               
                  193 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 5.86 
                 518.1 
               
               
                   
               
               
                  194 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 6.32 
                 582.1 
               
               
                   
               
               
                  195 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.16 
                 357.3 
               
               
                   
               
               
                  196 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 4.74 
                 395.2 
               
               
                   
               
               
                  197 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 4.86 
                 418.2 
               
               
                   
               
               
                  198 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 5.26 
                 461.2 
               
               
                   
               
               
                  199 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 5.12 
                 456.2 
               
               
                   
               
               
                  200 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 5.72 
                 513.2 
               
               
                   
               
               
                  201 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.51 
                 435.2 
               
               
                   
               
               
                  202 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 5.18 
                 435.3 
               
               
                   
               
               
                  203 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 5.37 
                 417.2 
               
               
                   
               
               
                  204 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 5.84 
                 481.2 
               
               
                   
               
               
                  205 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 3.63 
                 350.3 
               
               
                   
               
               
                  206 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 3.95 
                 388.2 
               
               
                   
               
               
                  207 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 4.07 
                 411.2 
               
               
                   
               
               
                  208 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 4.44 
                 454.2 
               
               
                   
               
               
                  209 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 4.38 
                 449.2 
               
               
                   
               
               
                  210 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89 
                 5.03 
                 506.2 
               
               
                   
               
               
                  211 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 3.87 
                 428.2 
               
               
                   
               
               
                  212 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 4.4 
                 428.3 
               
               
                   
               
               
                  213 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.63 
                 410.2 
               
               
                   
               
               
                  214 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.96 
                 474.2 
               
               
                   
               
               
                  215 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 5.38 
                 411.2 
               
               
                   
               
               
                  216 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 5.63 
                 449.2 
               
               
                   
               
               
                  217 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 5.77 
                 472.2 
               
               
                   
               
               
                  218 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 6.04 
                 515.2 
               
               
                   
               
               
                  219 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 5.74 
                 510.1 
               
               
                   
               
               
                  220 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91 
                 6.29 
                 567.2 
               
               
                   
               
               
                  221 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 5.53 
                 489.2 
               
               
                   
               
               
                  222 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 6.38 
                 489.3 
               
               
                   
               
               
                  223 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 6.0 
                 471.2 
               
               
                   
               
               
                  224 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 6.49 
                 535.1 
               
               
                   
               
               
                  225 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 3.99 
                 426.3 
               
               
                   
               
               
                  226 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 4.34 
                 464.2 
               
               
                   
               
               
                  227 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.43 
                 487.3 
               
               
                   
               
               
                  228 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 4.78 
                 530.2 
               
               
                   
               
               
                  229 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 4.76 
                 525.2 
               
               
                   
               
               
                  230 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 5.36 
                 582.2 
               
               
                   
               
               
                  231 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 4.23 
                 504.3 
               
               
                   
               
               
                  232 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 4.7 
                 504.3 
               
               
                   
               
               
                  233 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 4.99 
                 486.2 
               
               
                   
               
               
                  234 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 5.3 
                 550.2 
               
               
                   
               
               
                  235 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 3.44 
                 411.2 
               
               
                   
               
               
                  236 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 3.94 
                 449.2 
               
               
                   
               
               
                  237 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.11 
                 472.3 
               
               
                   
               
               
                  238 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 4.52 
                 515.2 
               
               
                   
               
               
                  239 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 4.39 
                 510.2 
               
               
                   
               
               
                  240 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 5.01 
                 567.2 
               
               
                   
               
               
                  241 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 3.74 
                 489.2 
               
               
                   
               
               
                  242 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.41 
                 489.3 
               
               
                   
               
               
                  243 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.56 
                 471.2 
               
               
                   
               
               
                  244 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 5.01 
                 535.2 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R3 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                  245 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.1 
                 3.2 
                 290.2 
               
               
                   
               
               
                  246 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.9 
                 3.78 
                 324.2 
               
               
                   
               
               
                  247 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.3 
                 3.88 
                 355.2 
               
               
                   
               
               
                  248 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 99.3 
                 3.79 
                 335.2 
               
               
                   
               
               
                  249 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 99.4 
                 3.86 
                 324.2 
               
               
                   
               
               
                  250 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 3.97 
                 351.2 
               
               
                   
               
               
                  251 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.7 
                 4.14 
                 388.1 
               
               
                   
               
               
                  252 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.5 
                 4.24 
                 379.3 
               
               
                   
               
               
                  253 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.4 
                 5.16 
                 446.2 
               
               
                   
               
               
                  254 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.8 
                 3.7 
                 368.2 
               
               
                   
               
               
                  255 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.5 
                 3.9 
                 332.3 
               
               
                   
               
               
                  256 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.3 
                 4.4 
                 366.3 
               
               
                   
               
               
                  257 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.3 
                 4.55 
                 397.2 
               
               
                   
               
               
                  258 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.4 
                 4.48 
                 377.3 
               
               
                   
               
               
                  259 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.3 
                 4.49 
                 366.3 
               
               
                   
               
               
                  260 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.4 
                 4.59 
                 393.3 
               
               
                   
               
               
                  261 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.7 
                 4.77 
                 430.2 
               
               
                   
               
               
                  262 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.9 
                 4.76 
                 421.3 
               
               
                   
               
               
                  263 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.7 
                 5.72 
                 488.2 
               
               
                   
               
               
                  264 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.7 
                 4.33 
                 410.3 
               
               
                   
               
               
                  265 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.5 
                 3.42 
                 369.2 
               
               
                   
               
               
                  266 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.9 
                 3.91 
                 403.2 
               
               
                   
               
               
                  267 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.1 
                 3.81 
                 434.2 
               
               
                   
               
               
                  268 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.9 
                 3.78 
                 414.1 
               
               
                   
               
               
                  269 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.1 
                 4.06 
                 403.2 
               
               
                   
               
               
                  270 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.2 
                 4.14 
                 430.2 
               
               
                   
               
               
                  271 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.3 
                 4.28 
                 467.1 
               
               
                   
               
               
                  272 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.8 
                 4.5 
                 458.2 
               
               
                   
               
               
                  273 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.3 
                 4.92 
                 525.2 
               
               
                   
               
               
                  274 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.1 
                 3.84 
                 447.2 
               
               
                   
               
               
                  275 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.5 
                 4.28 
                 354.2 
               
               
                   
               
               
                  276 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.3 
                 5.02 
                 388.2 
               
               
                   
               
               
                  277 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.7 
                 4.96 
                 419.2 
               
               
                   
               
               
                  278 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.8 
                 4.86 
                 399.2 
               
               
                   
               
               
                  279 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 5.13 
                 388.2 
               
               
                   
               
               
                  280 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.9 
                 5.18 
                 415.2 
               
               
                   
               
               
                  281 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.6 
                 5.31 
                 452.1 
               
               
                   
               
               
                  282 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.5 
                 5.54 
                 443.2 
               
               
                   
               
               
                  283 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.5 
                 5.89 
                 510.2 
               
               
                   
               
               
                  284 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.8 
                 4.89 
                 432.2 
               
               
                   
               
               
                  285 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.2 
                 5.08 
                 369.2 
               
               
                   
               
               
                  286 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.6 
                 5.31 
                 403.1 
               
               
                   
               
               
                  287 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.6 
                 5.07 
                 434.1 
               
               
                   
               
               
                  288 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 99.1 
                 5.05 
                 414.1 
               
               
                   
               
               
                  289 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 99.1 
                 5.39 
                 403.1 
               
               
                   
               
               
                  290 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.3 
                 5.44 
                 430.2 
               
               
                   
               
               
                  291 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 99.4 
                 5.47 
                 467.1 
               
               
                   
               
               
                  292 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.4 
                 5.86 
                 458.2 
               
               
                   
               
               
                  293 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 99.5 
                 5.87 
                 525.1 
               
               
                   
               
               
                  294 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.5 
                 5.21 
                 447.2 
               
               
                   
               
               
                  295 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.7 
                 4.41 
                 396.3 
               
               
                   
               
               
                  296 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.9 
                 5.06 
                 430.3 
               
               
                   
               
               
                  297 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54 
                 5.19 
                 461.2 
               
               
                   
               
               
                  298 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.8 
                 5.07 
                 441.2 
               
               
                   
               
               
                  299 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.8 
                 5.18 
                 430.3 
               
               
                   
               
               
                  300 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 5.28 
                 457.3 
               
               
                   
               
               
                  301 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.9 
                 5.45 
                 494.2 
               
               
                   
               
               
                  302 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87 
                 5.49 
                 485.3 
               
               
                   
               
               
                  303 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35.6 
                 6.18 
                 552.2 
               
               
                   
               
               
                  304 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.7 
                 4.97 
                 474.3 
               
               
                   
               
               
                  305 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.9 
                 5.24 
                 380.2 
               
               
                   
               
               
                  306 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 5.39 
                 414.2 
               
               
                   
               
               
                  307 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 5.14 
                 445.2 
               
               
                   
               
               
                  308 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.4 
                 5.11 
                 425.1 
               
               
                   
               
               
                  309 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.1 
                 5.47 
                 414.2 
               
               
                   
               
               
                  310 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.2 
                 5.47 
                 441.1 
               
               
                   
               
               
                  311 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 5.52 
                 478.1 
               
               
                   
               
               
                  312 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.3 
                 5.99 
                 469.2 
               
               
                   
               
               
                  313 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.3 
                 5.91 
                 536.1 
               
               
                   
               
               
                  314 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.5 
                 5.31 
                 458.2 
               
               
                   
               
               
                  315 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.7 
                 4.12 
                 340.3 
               
               
                   
               
               
                  316 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.4 
                 4.66 
                 374.2 
               
               
                   
               
               
                  317 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.9 
                 4.78 
                 405.2 
               
               
                   
               
               
                  318 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.8 
                 4.71 
                 385.2 
               
               
                   
               
               
                  319 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.1 
                 4.78 
                 374.2 
               
               
                   
               
               
                  320 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.2 
                 4.9 
                 401.2 
               
               
                   
               
               
                  321 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.8 
                 5.09 
                 438.1 
               
               
                   
               
               
                  322 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.8 
                 5.07 
                 429.3 
               
               
                   
               
               
                  323 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.5 
                 5.82 
                 496.2 
               
               
                   
               
               
                  324 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.5 
                 4.59 
                 418.2 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R3 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                  325 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 3.71 
                 358.2 
               
               
                   
               
               
                  326 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68 + 30 
                 4.0 + 4.1 
                 396.2 
               
               
                   
               
               
                  327 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69 + 31 
                 4.5 + 4.6 
                 462.2 
               
               
                   
               
               
                  328 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66 + 27 
                 4.7 + 4.8 
                 484.3 
               
               
                   
               
               
                  329 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67 + 31 
                 4.4 + 4.6 
                 457.2 
               
               
                   
               
               
                  330 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67 + 30 
                 4.3 + 4.5 
                 541.2 
               
               
                   
               
               
                  331 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62 + 33 
                 3.9 + 4.0 
                 436.2 
               
               
                   
               
               
                  332 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64 + 30 
                 3.5 + 3.6 
                 447.3 
               
               
                   
               
               
                  333 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65 + 30 
                 4.7 + 4.9 
                 418.2 
               
               
                   
               
               
                  334 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68 + 29 
                 3.8 + 3.9 
                 372.3 
               
               
                   
               
               
                  335 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69 + 29 
                 4.2 + 4.3 
                 410.2 
               
               
                   
               
               
                  336 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68 + 30 
                 4.6 + 4.8 
                 476.2 
               
               
                   
               
               
                  337 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61 + 32 
                  4.8 + 4.89 
                 498.3 
               
               
                   
               
               
                  338 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66 + 30 
                 4.55 + 4.71 
                 471.2 
               
               
                   
               
               
                  339 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68 + 29 
                 4.46 + 4.58 
                 555.2 
               
               
                   
               
               
                  340 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 22 + 11 
                 5.13 + 5.22 
                 520.4 
               
               
                   
               
               
                  341 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67 + 24 
                 4.09 + 4.14 
                 450.3 
               
               
                   
               
               
                  342 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71 + 23 
                  3.7 + 3.74 
                 461.3 
               
               
                   
               
               
                  343 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67 + 31 
                 4.82 + 5.02 
                 432.2 
               
               
                   
               
               
                  344 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66 + 31 
                 4.14 + 4.39 
                 404.3 
               
               
                   
               
               
                  345 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65 + 31 
                 4.74 + 4.94 
                 442.2 
               
               
                   
               
               
                  346 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65 + 31 
                 5.25 + 5.47 
                 508.2 
               
               
                   
               
               
                  347 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62 + 29 
                 5.28 + 5.5  
                 530.3 
               
               
                   
               
               
                  348 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65 + 30 
                 5.21 + 5.38 
                 503.2 
               
               
                   
               
               
                  349 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63 + 30 
                 5.03 + 5.24 
                 587.2 
               
               
                   
               
               
                  350 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64 + 30 
                 5.59 + 5.84 
                 552.3 
               
               
                   
               
               
                  351 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58 + 28 
                 4.49 + 4.66 
                 482.3 
               
               
                   
               
               
                  352 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64 + 26 
                 4.01 + 4.11 
                 493.3 
               
               
                   
               
               
                  353 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65 + 31 
                 5.54 + 5.71 
                 464.2 
               
               
                   
               
               
                  354 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 57 + 24 
                 4.08 + 4.19 
                 399.3 
               
               
                   
               
               
                  355 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62 + 28 
                 4.52 + 4.7  
                 437.2 
               
               
                   
               
               
                  356 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62 + 28 
                   5 + 5.2 
                 503.2 
               
               
                   
               
               
                  357 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58 + 26 
                 5.08 + 5.25 
                 525.3 
               
               
                   
               
               
                  358 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62 + 29 
                 4.98 + 5.19 
                 498.2 
               
               
                   
               
               
                  359 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62 + 29 
                 4.82 + 4.99 
                 582.2 
               
               
                   
               
               
                  360 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62 + 28 
                 5.39 + 5.58 
                 547.3 
               
               
                   
               
               
                  361 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56 + 26 
                 4.37 + 4.49 
                 477.3 
               
               
                   
               
               
                  362 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64 + 32 
                 5.32 + 5.55 
                 459.2 
               
               
                   
               
               
                  363 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 6.36 
                 505.2 
               
               
                   
               
               
                  364 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 6.39 
                 542.1 
               
               
                   
               
               
                  365 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 25 + 72 
                 6.74 + 6.77 
                 608.1 
               
               
                   
               
               
                  366 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 7.07 
                 630.2 
               
               
                   
               
               
                  367 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 23 + 73 
                 6.38 + 6.42 
                 603.1 
               
               
                   
               
               
                  368 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 26 + 69 
                 6.73 + 6.76 
                 687.1 
               
               
                   
               
               
                  369 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60 
                 7.55 
                 652.3 
               
               
                   
               
               
                  370 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 6.39 
                 582.1 
               
               
                   
               
               
                  371 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 5.74 
                 593.2 
               
               
                   
               
               
                  372 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 22 + 73 
                 6.68 + 6.74 
                 564.1 
               
               
                   
               
               
                  373 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59 + 27 
                 4.88 + 5.13 
                 403.3 
               
               
                   
               
               
                  374 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67 + 30 
                 5.35 + 5.44 
                 441.2 
               
               
                   
               
               
                  375 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64 + 34 
                 5.84 + 5.92 
                 507.2 
               
               
                   
               
               
                  376 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62 + 28 
                   6 + 6.13 
                 529.3 
               
               
                   
               
               
                  377 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 5.58 
                 502.2 
               
               
                   
               
               
                  378 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65 + 32 
                 5.71 + 5.8  
                 586.2 
               
               
                   
               
               
                  379 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 49 + 23 
                 6.45 + 6.58 
                 551.3 
               
               
                   
               
               
                  380 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61 + 26 
                 5.18 + 5.3  
                 481.2 
               
               
                   
               
               
                  381 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 45 + 21 
                 4.57 + 4.68 
                 492.3 
               
               
                   
               
               
                  382 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84 
                 5.9 
                 463.2 
               
               
                   
               
               
                  383 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56 + 26 
                 4.65 + 4.89 
                 410.2 
               
               
                   
               
               
                  384 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64 + 30 
                 5.29 + 5.47 
                 448.2 
               
               
                   
               
               
                  385 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65 + 30 
                 5.78 + 5.95 
                 514.2 
               
               
                   
               
               
                  386 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63 + 27 
                  5.8 + 6.02 
                 536.2 
               
               
                   
               
               
                  387 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65 + 31 
                 5.71 + 5.81 
                 509.1 
               
               
                   
               
               
                  388 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62 + 32 
                 5.59 + 5.79 
                 593.1 
               
               
                   
               
               
                  389 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 30 + 14 
                 6.22 + 6.45 
                 558.3 
               
               
                   
               
               
                  390 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 57 + 26 
                 5.01 + 5.2  
                 488.2 
               
               
                   
               
               
                  391 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54 + 26 
                 4.46 + 4.61 
                 499.2 
               
               
                   
               
               
                  392 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 27 + 11 
                 6.09 + 6.18 
                 470.2 
               
               
                   
               
               
                  393 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63 + 29 
                 4.53 + 4.6  
                 464.3 
               
               
                   
               
               
                  394 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65 + 30 
                 4.78 + 4.93 
                 502.3 
               
               
                   
               
               
                  395 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61 + 28 
                 5.16 + 5.35 
                 568.2 
               
               
                   
               
               
                  396 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59 + 25 
                  5.3 + 5.42 
                 590.3 
               
               
                   
               
               
                  397 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60 + 30 
                 5.12 + 5.34 
                 563.2 
               
               
                   
               
               
                  398 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63 + 32 
                 5.01 + 5.17 
                 647.2 
               
               
                   
               
               
                  399 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59 + 26 
                 5.55 + 5.7  
                 612.4 
               
               
                   
               
               
                  400 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 52 + 14 
                 4.35 + 4.4  
                 553.3 
               
               
                   
               
               
                  401 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61 + 29 
                 5.36 + 5.64 
                 524.3 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R3 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                  402 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.5 
                 4.52 
                 442.1 
               
               
                   
               
               
                  403 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.6 
                 4.72 
                 432.15 
               
               
                   
               
               
                  404 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 4.78 
                 455.16 
               
               
                   
               
               
                  405 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.6 
                 5.19 
                 493.12 
               
               
                   
               
               
                  406 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.8 
                 4.99 
                 577.11 
               
               
                   
               
               
                  407 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.1 
                 4.44 
                 472.19 
               
               
                   
               
               
                  408 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.3 
                 4.0 
                 483.21 
               
               
                   
               
               
                  409 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.5 
                 5.35 
                 498.04 
               
               
                   
               
               
                  410 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.1 
                 5.61 
                 454.15 
               
               
                   
               
               
                  411 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83 
                 5.43 
                 526.03 
               
               
                   
               
               
                  412 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.9 
                 5.4 
                 515.97 
               
               
                   
               
               
                  413 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.4 
                 5.52 
                 539.00 
               
               
                   
               
               
                  414 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.1 
                 5.48 
                 576.95 
               
               
                   
               
               
                  415 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.7 
                 5.69 
                 660.99 
               
               
                   
               
               
                  416 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.2 
                 5.27 
                 555.98 
               
               
                   
               
               
                  417 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 4.7 
                 567.00 
               
               
                   
               
               
                  418 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.7 
                 5.73 
                 581.87 
               
               
                   
               
               
                  419 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.8 
                 5.77 
                 538.00 
               
               
                   
               
               
                  420 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.4 
                 4.74 
                 446.14 
               
               
                   
               
               
                  421 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.6 
                 4.9 
                 436.08 
               
               
                   
               
               
                  422 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.2 
                 5.0 
                 459.10 
               
               
                   
               
               
                  423 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.4 
                 5.0 
                 487.16 
               
               
                   
               
               
                  424 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.9 
                 5.19 
                 497.07 
               
               
                   
               
               
                  425 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.7 
                 5.18 
                 581.05 
               
               
                   
               
               
                  426 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.5 
                 4.67 
                 476.12 
               
               
                   
               
               
                  427 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.6 
                 4.16 
                 487.13 
               
               
                   
               
               
                  428 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.7 
                 5.38 
                 501.96 
               
               
                   
               
               
                  429 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.9 
                 5.48 
                 458.10 
               
               
                   
               
               
                  430 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.1 
                 5.26 
                 484.14 
               
               
                   
               
               
                  431 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.7 
                 5.41 
                 474.10 
               
               
                   
               
               
                  432 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.6 
                 5.51 
                 497.12 
               
               
                   
               
               
                  433 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.4 
                 5.64 
                 535.01 
               
               
                   
               
               
                  434 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.2 
                 5.69 
                 619.04 
               
               
                   
               
               
                  435 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.4 
                 5.21 
                 514.10 
               
               
                   
               
               
                  436 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.7 
                 4.67 
                 525.11 
               
               
                   
               
               
                  437 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.7 
                 5.84 
                 539.94 
               
               
                   
               
               
                  438 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91 
                 5.93 
                 496.09 
               
               
                   
               
               
                  439 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.4 
                 4.82 
                 492.18 
               
               
                   
               
               
                  440 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.2 
                 5.03 
                 482.14 
               
               
                   
               
               
                  441 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.4 
                 5.08 
                 505.15 
               
               
                   
               
               
                  442 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33.4 
                 5.14 
                 533.18 
               
               
                   
               
               
                  443 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.6 
                 5.45 
                 543.07 
               
               
                   
               
               
                  444 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.9 
                 5.26 
                 627.10 
               
               
                   
               
               
                  445 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.6 
                 4.78 
                 522.14 
               
               
                   
               
               
                  446 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 4.34 
                 533.15 
               
               
                   
               
               
                  447 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.6 
                 5.6 
                 547.98 
               
               
                   
               
               
                  448 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.6 
                 5.82 
                 504.14 
               
               
                   
               
               
                  449 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.9 
                 5.76 
                 468.08 
               
               
                   
               
               
                  450 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.4 
                 5.54 
                 458.03 
               
               
                   
               
               
                  451 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.3 
                 5.74 
                 481.03 
               
               
                   
               
               
                  452 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.3 
                 6.21 
                 509.06 
               
               
                   
               
               
                  453 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.4 
                 5.62 
                 518.97 
               
               
                   
               
               
                  454 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 5.91 
                 602.90 
               
               
                   
               
               
                  455 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.4 
                 5.54 
                 498.06 
               
               
                   
               
               
                  456 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.4 
                 4.98 
                 509.06 
               
               
                   
               
               
                  457 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.7 
                 5.9 
                 523.88 
               
               
                   
               
               
                  458 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.5 
                 5.88 
                 480.05 
               
               
                   
               
               
                  459 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.2 
                 4.69 
                 506.18 
               
               
                   
               
               
                  460 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.1 
                 4.87 
                 496.15 
               
               
                   
               
               
                  461 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.2 
                 4.92 
                 519.15 
               
               
                   
               
               
                  462 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 26.9 
                 5.01 
                 547.17 
               
               
                   
               
               
                  463 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.9 
                 5.26 
                 557.08 
               
               
                   
               
               
                  464 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.2 
                 5.08 
                 641.13 
               
               
                   
               
               
                  465 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.7 
                 4.64 
                 536.15 
               
               
                   
               
               
                  466 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.3 
                 4.24 
                 547.15 
               
               
                   
               
               
                  467 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.3 
                 5.39 
                 562.00 
               
               
                   
               
               
                  468 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 5.6 
                 518.14 
               
               
                   
               
               
                  469 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.3 
                 4.59 
                 494.13 
               
               
                   
               
               
                  470 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.1 
                 4.73 
                 484.11 
               
               
                   
               
               
                  471 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.4 
                 4.81 
                 507.11 
               
               
                   
               
               
                  472 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 10.7 
                 4.9 
                 535.14 
               
               
                   
               
               
                  473 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.4 
                 5.07 
                 545.02 
               
               
                   
               
               
                  474 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.5 
                 4.98 
                 629.05 
               
               
                   
               
               
                  475 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.2 
                 4.5 
                 524.08 
               
               
                   
               
               
                  476 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.06 
                 535.09 
               
               
                   
               
               
                  477 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.3 
                 5.22 
                 549.95 
               
               
                   
               
               
                  478 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.1 
                 5.36 
                 506.08 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R3 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                  479 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 45.6 
                 4.95 
                 377.14 
               
               
                   
               
               
                  480 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79 
                 5.17 
                 431.07 
               
               
                   
               
               
                  481 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56.8 
                 4.84 
                 442.08 
               
               
                   
               
               
                  482 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.2 
                 5.04 
                 415.07 
               
               
                   
               
               
                  483 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.4 
                 5.25 
                 438.11 
               
               
                   
               
               
                  484 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.6 
                 5.47 
                 481.10 
               
               
                   
               
               
                  485 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.6 
                 5.81 
                 503.17 
               
               
                   
               
               
                  486 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79 
                 5.36 
                 560.04 
               
               
                   
               
               
                  487 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.1 
                 5.34 
                 480.98 
               
               
                   
               
               
                  488 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.9 
                 5.0 
                 441.09 
               
               
                   
               
               
                  489 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.5 
                 4.6 
                 386.09 
               
               
                   
               
               
                  490 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.4 
                 5.34 
                 440.04 
               
               
                   
               
               
                  491 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.3 
                 5.05 
                 451.06 
               
               
                   
               
               
                  492 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.2 
                 5.23 
                 424.07 
               
               
                   
               
               
                  493 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.4 
                 5.35 
                 447.07 
               
               
                   
               
               
                  494 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.1 
                 5.67 
                 490.07 
               
               
                   
               
               
                  495 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.5 
                 5.84 
                 512.12 
               
               
                   
               
               
                  496 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.9 
                 5.55 
                 569.00 
               
               
                   
               
               
                  497 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 5.64 
                 489.95 
               
               
                   
               
               
                  498 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 5.03 
                 450.08 
               
               
                   
               
               
                  499 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.5 
                 4.87 
                 397.11 
               
               
                   
               
               
                  500 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.1 
                 5.26 
                 451.06 
               
               
                   
               
               
                  501 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.1 
                 4.95 
                 462.07 
               
               
                   
               
               
                  502 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.3 
                 5.15 
                 435.08 
               
               
                   
               
               
                  503 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.2 
                 5.31 
                 458.11 
               
               
                   
               
               
                  504 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.5 
                 5.57 
                 501.08 
               
               
                   
               
               
                  505 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.3 
                 5.86 
                 523.15 
               
               
                   
               
               
                  506 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.8 
                 5.46 
                 580.03 
               
               
                   
               
               
                  507 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.2 
                 5.45 
                 500.96 
               
               
                   
               
               
                  508 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.5 
                 5.07 
                 461.08 
               
               
                   
               
               
                  509 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.5 
                 4.29 
                 408.18 
               
               
                   
               
               
                  510 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.2 
                 4.98 
                 462.13 
               
               
                   
               
               
                  511 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.4 
                 4.81 
                 473.19 
               
               
                   
               
               
                  512 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.3 
                 4.9 
                 446.17 
               
               
                   
               
               
                  513 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.7 
                 4.93 
                 469.19 
               
               
                   
               
               
                  514 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.9 
                 5.29 
                 512.17 
               
               
                   
               
               
                  515 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.6 
                 5.33 
                 534.20 
               
               
                   
               
               
                  516 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.3 
                 5.15 
                 591.13 
               
               
                   
               
               
                  517 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.5 
                 5.47 
                 512.04 
               
               
                   
               
               
                  518 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 4.65 
                 472.19 
               
               
                   
               
               
                  519 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.5 
                 5.14 
                 420.13 
               
               
                   
               
               
                  520 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.6 
                 5.63 
                 474.07 
               
               
                   
               
               
                  521 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.8 
                 5.35 
                 485.10 
               
               
                   
               
               
                  522 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.1 
                 5.53 
                 458.09 
               
               
                   
               
               
                  523 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.2 
                 5.67 
                 481.10 
               
               
                   
               
               
                  524 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.6 
                 5.9 
                 524.09 
               
               
                   
               
               
                  525 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.4 
                 6.15 
                 546.11 
               
               
                   
               
               
                  526 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.6 
                 5.83 
                 603.07 
               
               
                   
               
               
                  527 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.8 
                 5.87 
                 523.97 
               
               
                   
               
               
                  528 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.3 
                 5.41 
                 484.11 
               
               
                   
               
               
                  529 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98.2 
                 3.75 
                 380.18 
               
               
                   
               
               
                  530 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.4 
                 4.35 
                 434.11 
               
               
                   
               
               
                  531 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.5 
                 4.19 
                 445.13 
               
               
                   
               
               
                  532 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.7 
                 4.25 
                 418.14 
               
               
                   
               
               
                  533 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.4 
                 4.33 
                 441.13 
               
               
                   
               
               
                  534 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.5 
                 4.69 
                 484.14 
               
               
                   
               
               
                  535 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.5 
                 4.81 
                 506.18 
               
               
                   
               
               
                  536 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.5 
                 4.54 
                 563.08 
               
               
                   
               
               
                  537 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.2 
                 4.79 
                 484.03 
               
               
                   
               
               
                  538 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.7 
                 4.07 
                 444.14 
               
               
                   
               
               
                  539 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.4 
                 4.25 
                 416.10 
               
               
                   
               
               
                  540 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.7 
                 5.05 
                 470.07 
               
               
                   
               
               
                  541 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.6 
                 4.81 
                 481.05 
               
               
                   
               
               
                  542 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.4 
                 4.96 
                 454.07 
               
               
                   
               
               
                  543 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.4 
                 5.05 
                 477.10 
               
               
                   
               
               
                  544 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.9 
                 5.4 
                 520.04 
               
               
                   
               
               
                  545 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.5 
                 5.51 
                 542.11 
               
               
                   
               
               
                  546 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 5.26 
                 599.02 
               
               
                   
               
               
                  547 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.9 
                 5.4 
                 519.93 
               
               
                   
               
               
                  548 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.3 
                 4.72 
                 480.08 
               
               
                   
               
               
                  549 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 6.01 
                 585.84 
               
               
                   
               
               
                  550 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.7 
                 6.18 
                 639.79 
               
               
                   
               
               
                  551 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.8 
                 5.84 
                 650.83 
               
               
                   
               
               
                  552 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 6.04 
                 623.81 
               
               
                   
               
               
                  553 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.7 
                 6.22 
                 646.85 
               
               
                   
               
               
                  554 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 6.39 
                 689.82 
               
               
                   
               
               
                  555 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.8 
                 6.7 
                 711.88 
               
               
                   
               
               
                  556 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.9 
                 6.4 
                 768.76 
               
               
                   
               
               
                  557 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 6.35 
                 689.71 
               
               
                   
               
               
                  558 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.7 
                 6.01 
                 649.83 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R3 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                  559 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.5 
                 4.07 
                 408.18 
               
               
                   
               
               
                  560 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.6 
                 4.15 
                 458.09 
               
               
                   
               
               
                  561 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.5 
                 4.04 
                 421.17 
               
               
                   
               
               
                  562 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54.6 
                 4.37 
                 449.23 
               
               
                   
               
               
                  563 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.7 
                 4.85 
                 516.14 
               
               
                   
               
               
                  564 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.5 
                 4.27 
                 459.14 
               
               
                   
               
               
                  565 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.2 
                 3.87 
                 438.18 
               
               
                   
               
               
                  566 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.6 
                 4.41 
                 444.2 
               
               
                   
               
               
                  567 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.2 
                 3.5 
                 449.21 
               
               
                   
               
               
                  568 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.4 
                 4.53 
                 420.17 
               
               
                   
               
               
                  569 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.7 
                 4.23 
                 422.21 
               
               
                   
               
               
                  570 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.7 
                 4.38 
                 472.12 
               
               
                   
               
               
                  571 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.7 
                 4.27 
                 435.19 
               
               
                   
               
               
                  572 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.2 
                 4.53 
                 463.25 
               
               
                   
               
               
                  573 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.8 
                 5.15 
                 530.18 
               
               
                   
               
               
                  574 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.6 
                 4.55 
                 473.17 
               
               
                   
               
               
                  575 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.8 
                 4.07 
                 452.21 
               
               
                   
               
               
                  576 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.4 
                 4.65 
                 458.24 
               
               
                   
               
               
                  577 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.8 
                 3.71 
                 463.23 
               
               
                   
               
               
                  578 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.6 
                 4.85 
                 434.20 
               
               
                   
               
               
                  579 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.1 
                 4.38 
                 436.23 
               
               
                   
               
               
                  580 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.7 
                 4.56 
                 486.14 
               
               
                   
               
               
                  581 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.9 
                 4.43 
                 449.24 
               
               
                   
               
               
                  582 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.4 
                 4.65 
                 477.25 
               
               
                   
               
               
                  583 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 5.34 
                 544.19 
               
               
                   
               
               
                  584 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.3 
                 4.75 
                 487.20 
               
               
                   
               
               
                  585 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.2 
                 4.23 
                 466.23 
               
               
                   
               
               
                  586 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 4.82 
                 472.28 
               
               
                   
               
               
                  587 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.1 
                 3.88 
                 477.28 
               
               
                   
               
               
                  588 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.7 
                 5.06 
                 448.23 
               
               
                   
               
               
                  589 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.1 
                 4.62 
                 419.20 
               
               
                   
               
               
                  590 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 5.06 
                 469.09 
               
               
                   
               
               
                  591 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88 
                 4.89 
                 432.18 
               
               
                   
               
               
                  592 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.5 
                 5.02 
                 460.23 
               
               
                   
               
               
                  593 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.2 
                 5.69 
                 527.16 
               
               
                   
               
               
                  594 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.6 
                 5.11 
                 470.15 
               
               
                   
               
               
                  595 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.2 
                 4.53 
                 449.19 
               
               
                   
               
               
                  596 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.9 
                 5.4 
                 455.19 
               
               
                   
               
               
                  597 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.2 
                 3.99 
                 460.20 
               
               
                   
               
               
                  598 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 5.41 
                 431.16 
               
               
                   
               
               
                  599 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.1 
                 4.05 
                 424.22 
               
               
                   
               
               
                  600 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.8 
                 4.17 
                 474.12 
               
               
                   
               
               
                  601 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.2 
                 4.04 
                 437.19 
               
               
                   
               
               
                  602 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.4 
                 4.34 
                 465.24 
               
               
                   
               
               
                  603 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.5 
                 4.91 
                 532.19 
               
               
                   
               
               
                  604 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.4 
                 4.3 
                 475.16 
               
               
                   
               
               
                  605 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.9 
                 3.86 
                 454.20 
               
               
                   
               
               
                  606 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.8 
                 4.47 
                 460.25 
               
               
                   
               
               
                  607 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.7 
                 3.48 
                 465.21 
               
               
                   
               
               
                  608 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 4.55 
                 436.19 
               
               
                   
               
               
                  609 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.9 
                 5.19 
                 541.25 
               
               
                   
               
               
                  610 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.4 
                 5.6 
                 591.13 
               
               
                   
               
               
                  611 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.7 
                 5.45 
                 554.23 
               
               
                   
               
               
                  612 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.7 
                 5.58 
                 582.28 
               
               
                   
               
               
                  613 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.2 
                 6.06 
                 649.24 
               
               
                   
               
               
                  614 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.1 
                 5.55 
                 592.18 
               
               
                   
               
               
                  615 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90 
                 5.09 
                 571.23 
               
               
                   
               
               
                  616 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.3 
                 5.91 
                 577.26 
               
               
                   
               
               
                  617 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.4 
                 4.53 
                 582.24 
               
               
                   
               
               
                  618 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.1 
                 5.84 
                 553.22 
               
               
                   
               
               
                  619 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.6 
                 5.06 
                 490.15 
               
               
                   
               
               
                  620 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.2 
                 5.56 
                 539.99 
               
               
                   
               
               
                  621 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.7 
                 5.39 
                 503.12 
               
               
                   
               
               
                  622 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 5.47 
                 531.15 
               
               
                   
               
               
                  623 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.2 
                 6.13 
                 598.06 
               
               
                   
               
               
                  624 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.8 
                 5.59 
                 541.03 
               
               
                   
               
               
                  625 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88 
                 5.04 
                 520.11 
               
               
                   
               
               
                  626 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.6 
                 5.91 
                 526.14 
               
               
                   
               
               
                  627 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.4 
                 4.49 
                 531.11 
               
               
                   
               
               
                  628 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.3 
                 5.89 
                 502.10 
               
               
                   
               
               
                  629 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.3 
                 4.41 
                 458.20 
               
               
                   
               
               
                  630 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.5 
                 4.72 
                 508.08 
               
               
                   
               
               
                  631 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.8 
                 4.57 
                 471.18 
               
               
                   
               
               
                  632 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 57.7 
                 4.71 
                 499.23 
               
               
                   
               
               
                  633 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 5.54 
                 566.12 
               
               
                   
               
               
                  634 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.5 
                 4.93 
                 509.13 
               
               
                   
               
               
                  635 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.3 
                 4.29 
                 488.19 
               
               
                   
               
               
                  636 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.6 
                 4.99 
                 494.21 
               
               
                   
               
               
                  637 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.7 
                 3.88 
                 499.21 
               
               
                   
               
               
                  638 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.9 
                 5.22 
                 470.18 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R3 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                  639 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 7.28 
                 374.10 
               
               
                   
               
               
                  640 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87 
                 7.62 
                 364.24 
               
               
                   
               
               
                  641 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84 
                 6.75 
                 342.23 
               
               
                   
               
               
                  642 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79 
                 6.6 
                 321.24 
               
               
                   
               
               
                  643 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 4.96 
                 339.29 
               
               
                   
               
               
                  644 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 6.44 
                 324.28 
               
               
                   
               
               
                  645 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83 
                 7.16 
                 338.30 
               
               
                   
               
               
                  646 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59 
                 6.6 
                 356.25 
               
               
                   
               
               
                  647 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86 
                 7.28 
                 402.23 
               
               
                   
               
               
                  648 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84 
                 7.29 
                 346.26 
               
               
                   
               
               
                  649 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85 
                 7.66 
                 388.1 
               
               
                   
               
               
                  650 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84 
                 7.96 
                 378.21 
               
               
                   
               
               
                  651 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85 
                 7.14 
                 356.23 
               
               
                   
               
               
                  652 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73 
                 7.02 
                 335.26 
               
               
                   
               
               
                  653 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76 
                 5.37 
                 353.29 
               
               
                   
               
               
                  654 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83 
                 6.84 
                 338.30 
               
               
                   
               
               
                  655 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 7.51 
                 352.29 
               
               
                   
               
               
                  656 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75 
                 6.99 
                 370.27 
               
               
                   
               
               
                  657 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77 
                 7.6 
                 416.26 
               
               
                   
               
               
                  658 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80 
                 7.65 
                 360.25 
               
               
                   
               
               
                  659 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87 
                 7.37 
                 392.10 
               
               
                   
               
               
                  660 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71 
                 7.7 
                 382.16 
               
               
                   
               
               
                  661 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63 
                 6.9 
                 360.21 
               
               
                   
               
               
                  662 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59 
                 6.7 
                 339.23 
               
               
                   
               
               
                  663 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80 
                 5.06 
                 357.26 
               
               
                   
               
               
                  664 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63 
                 6.61 
                 342.26 
               
               
                   
               
               
                  665 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 7.28 
                 356.25 
               
               
                   
               
               
                  666 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 39 
                 6.74 
                 374.22 
               
               
                   
               
               
                  667 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85 
                 7.42 
                 420.24 
               
               
                   
               
               
                  668 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 7.39 
                 364.26 
               
               
                   
               
               
                  669 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 8.28 
                 443.2 
               
               
                   
               
               
                  670 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88 
                 8.61 
                 433.2 
               
               
                   
               
               
                  671 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88 
                 7.7 
                 411.2 
               
               
                   
               
               
                  672 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80 
                 7.76 
                 390.26 
               
               
                   
               
               
                  673 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85 
                 6.08 
                 408.3 
               
               
                   
               
               
                  674 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89 
                 7.36 
                 393.3 
               
               
                   
               
               
                  675 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84 
                 8.03 
                 407.3 
               
               
                   
               
               
                  676 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 7.59 
                 425.3 
               
               
                   
               
               
                  677 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83 
                 8.03 
                 471.3 
               
               
                   
               
               
                  678 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91 
                 8.24 
                 415.2 
               
               
                   
               
               
                  679 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78 
                 7.41 
                 419.09 
               
               
                   
               
               
                  680 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75 
                 6.98 
                 369.23 
               
               
                   
               
               
                  681 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 7.51 
                 383.23 
               
               
                   
               
               
                  682 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85 
                 7.46 
                 391.20 
               
               
                   
               
               
                  683 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74 
                 6.79 
                 351.21 
               
               
                   
               
               
                  684 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 5.18 
                 369.26 
               
               
                   
               
               
                  685 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76 
                 6.73 
                 354.26 
               
               
                   
               
               
                  686 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87 
                 7.39 
                 368.27 
               
               
                   
               
               
                  687 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80 
                 7.48 
                 376.22 
               
               
                   
               
               
                  688 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83 
                 8.14 
                 424.11 
               
               
                   
               
               
                  689 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83 
                 8.37 
                 414.14 
               
               
                   
               
               
                  690 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78 
                 7.48 
                 371.21 
               
               
                   
               
               
                  691 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85 
                 5.88 
                 389.24 
               
               
                   
               
               
                  692 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79 
                 7.53 
                 374.24 
               
               
                   
               
               
                  693 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83 
                 8.1 
                 388.23 
               
               
                   
               
               
                  694 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77 
                 8.18 
                 452.23 
               
               
                   
               
               
                  695 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 8.14 
                 396.20 
               
               
                   
               
               
                  696 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76 
                 7.94 
                 413.16 
               
               
                   
               
               
                  697 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86 
                 7.41 
                 402.01 
               
               
                   
               
               
                  698 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 7.57 
                 360.16 
               
               
                   
               
               
                  699 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74 
                 6.32 
                 361.23 
               
               
                   
               
               
                  700 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88 
                 7.75 
                 344.19 
               
               
                   
               
               
                  701 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83 
                 6.88 
                 317.22 
               
               
                   
               
               
                  702 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 8.33 
                 509.9 
               
               
                   
               
               
                  703 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90 
                 8.69 
                 411.99 
               
               
                   
               
               
                  704 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72 
                 8.16 
                 382.21 
               
               
                   
               
               
                  705 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 7.27 
                 382.2 
               
               
                   
               
               
                  706 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 7.7 
                 436.05 
               
               
                   
               
               
                  707 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91 
                 7.85 
                 394.16 
               
               
                   
               
               
                  708 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80 
                 6.59 
                 395.19 
               
               
                   
               
               
                  709 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87 
                 7.99 
                 378.16 
               
               
                   
               
               
                  710 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83 
                 7.3 
                 351.2 
               
               
                   
               
               
                  711 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89 
                 8.58 
                 543.85 
               
               
                   
               
               
                  712 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89 
                 8.9 
                 446.01 
               
               
                   
               
               
                  713 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72 
                 8.35 
                 416.19 
               
               
                   
               
               
                  714 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 7.62 
                 416.19 
               
               
                   
               
               
                  715 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85 
                 7.84 
                 436.05 
               
               
                   
               
               
                  716 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88 
                 7.97 
                 394.14 
               
               
                   
               
               
                  717 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75 
                 6.82 
                 395.21 
               
               
                   
               
               
                  718 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88 
                 8.13 
                 378.13 
               
               
                   
               
               
                  719 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78 
                 7.5 
                 351.2 
               
               
                   
               
               
                  720 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91 
                 8.65 
                 543.86 
               
               
                   
               
               
                  721 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89 
                 8.97 
                 446.0 
               
               
                   
               
               
                  722 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75 
                 8.55 
                 416.19 
               
               
                   
               
               
                  723 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83 
                 7.84 
                 416.19 
               
               
                   
               
               
                  724 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90 
                 8.24 
                 506.01 
               
               
                   
               
               
                  725 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88 
                 8.37 
                 464.1 
               
               
                   
               
               
                  726 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76 
                 7.43 
                 465.17 
               
               
                   
               
               
                  727 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86 
                 8.52 
                 448.1 
               
               
                   
               
               
                  728 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84 
                 8.11 
                 421.11 
               
               
                   
               
               
                  729 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89 
                 8.97 
                 613.8 
               
               
                   
               
               
                  730 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90 
                 9.24 
                 515.94 
               
               
                   
               
               
                  731 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74 
                 8.94 
                 486.17 
               
               
                   
               
               
                  732 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 8.51 
                 486.16 
               
               
                   
               
               
                  733 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 8.15 
                 584.93 
               
               
                   
               
               
                  734 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 8.26 
                 543.05 
               
               
                   
               
               
                  735 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69 
                 7.31 
                 544.1 
               
               
                   
               
               
                  736 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80 
                 8.43 
                 527.07 
               
               
                   
               
               
                  737 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 7.99 
                 500.1 
               
               
                   
               
               
                  738 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88 
                 8.92 
                 692.79 
               
               
                   
               
               
                  739 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85 
                 9.23 
                 594.87 
               
               
                   
               
               
                  740 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71 
                 8.84 
                 565.1 
               
               
                   
               
               
                  741 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79 
                 8.36 
                 565.08 
               
               
                   
               
               
                  742 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 7.77 
                 475.06 
               
               
                   
               
               
                  743 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 7.91 
                 433.13 
               
               
                   
               
               
                  744 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86 
                 6.72 
                 434.21 
               
               
                   
               
               
                  745 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 8.03 
                 417.15 
               
               
                   
               
               
                  746 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74 
                 7.32 
                 390.17 
               
               
                   
               
               
                  747 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86 
                 8.61 
                 582.85 
               
               
                   
               
               
                  748 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76 
                 8.94 
                 485.01 
               
               
                   
               
               
                  749 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73 
                 8.33 
                 455.19 
               
               
                   
               
               
                  750 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84 
                 7.59 
                 455.2 
               
               
                   
               
               
                  751 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67 
                 8.82 
                 525.96 
               
               
                   
               
               
                  752 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75 
                 8.93 
                 484.08 
               
               
                   
               
               
                  753 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68 
                 8.08 
                 485.14 
               
               
                   
               
               
                  754 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75 
                 9.08 
                 468.06 
               
               
                   
               
               
                  755 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78 
                 8.77 
                 441.06 
               
               
                   
               
               
                  756 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 9.56 
                 633.79 
               
               
                   
               
               
                  757 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 9.77 
                 535.91 
               
               
                   
               
               
                  758 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70 
                 9.55 
                 506.12 
               
               
                   
               
               
                  759 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78 
                 9.21 
                 506.13 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R3 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                  760 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.9 
                 5.03 
                 436.23 
               
               
                   
               
               
                  761 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.4 
                 5.56 
                 422.33 
               
               
                   
               
               
                  762 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.36 
                 4.94 
                 420.26 
               
               
                   
               
               
                  763 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.08 
                 5.09 
                 428.30 
               
               
                   
               
               
                  764 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.6 
                 4.42 
                 423.34 
               
               
                   
               
               
                  765 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.4 
                 5.52 
                 480.38 
               
               
                   
               
               
                  766 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.6 
                 4.8 
                 402.25 
               
               
                   
               
               
                  767 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.8 
                 5.79 
                 462.37 
               
               
                   
               
               
                  768 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.9 
                 5.12 
                 460.20 
               
               
                   
               
               
                  769 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.4 
                 5.14 
                 476.21 
               
               
                   
               
               
                  770 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.2 
                 5.67 
                 514.18 
               
               
                   
               
               
                  771 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.0 
                 5.37 
                 464.18 
               
               
                   
               
               
                  772 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.5 
                 5.64 
                 572.07 
               
               
                   
               
               
                  773 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.9 
                 5.76 
                 522.21 
               
               
                   
               
               
                  774 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.2 
                 5.12 
                 474.23 
               
               
                   
               
               
                  775 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.1 
                 5.82 
                 530.27 
               
               
                   
               
               
                  776 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.8 
                 4.55 
                 408.22 
               
               
                   
               
               
                  777 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.7 
                 5.13 
                 394.34 
               
               
                   
               
               
                  778 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.6 
                 4.45 
                 392.23 
               
               
                   
               
               
                  779 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.8 
                 4.65 
                 400.30 
               
               
                   
               
               
                  780 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.5 
                 3.94 
                 395.33 
               
               
                   
               
               
                  781 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.8 
                 5.11 
                 452.38 
               
               
                   
               
               
                  782 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.7 
                 4.33 
                 374.29 
               
               
                   
               
               
                  783 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.5 
                 5.35 
                 434.38 
               
               
                   
               
               
                  784 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.1 
                 4.61 
                 424.25 
               
               
                   
               
               
                  785 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.3 
                 5.28 
                 410.33 
               
               
                   
               
               
                  786 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 4.49 
                 408.22 
               
               
                   
               
               
                  787 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.4 
                 4.74 
                 416.27 
               
               
                   
               
               
                  788 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.8 
                 3.95 
                 411.30 
               
               
                   
               
               
                  789 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.9 
                 5.27 
                 468.36 
               
               
                   
               
               
                  790 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.9 
                 4.39 
                 390.28 
               
               
                   
               
               
                  791 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.5 
                 5.53 
                 450.37 
               
               
                   
               
               
                  792 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90 
                 5.5 
                 462.19 
               
               
                   
               
               
                  793 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.9 
                 6.25 
                 448.31 
               
               
                   
               
               
                  794 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.9 
                 5.41 
                 446.22 
               
               
                   
               
               
                  795 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.5 
                 5.76 
                 454.26 
               
               
                   
               
               
                  796 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.8 
                 4.95 
                 449.30 
               
               
                   
               
               
                  797 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.4 
                 6.22 
                 506.34 
               
               
                   
               
               
                  798 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 5.52 
                 428.245 
               
               
                   
               
               
                  799 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 6.39 
                 488.34 
               
               
                   
               
               
                  800 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.6 
                 5.11 
                 412.20 
               
               
                   
               
               
                  801 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.5 
                 5.9 
                 398.30 
               
               
                   
               
               
                  802 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.5 
                 5 
                 396.20 
               
               
                   
               
               
                  803 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.2 
                 5.35 
                 404.26 
               
               
                   
               
               
                  804 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.7 
                 4.41 
                 399.28 
               
               
                   
               
               
                  805 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.2 
                 5.87 
                 456.34 
               
               
                   
               
               
                  806 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.3 
                 5.05 
                 378.23 
               
               
                   
               
               
                  807 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.9 
                 6.07 
                 438.33 
               
               
                   
               
               
                  808 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.8 
                 5.43 
                 520.09 
               
               
                   
               
               
                  809 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 6.19 
                 506.19 
               
               
                   
               
               
                  810 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.9 
                 5.33 
                 504.12 
               
               
                   
               
               
                  811 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.9 
                 5.68 
                 512.15 
               
               
                   
               
               
                  812 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.9 
                 4.8 
                 507.18 
               
               
                   
               
               
                  813 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.3 
                 6.17 
                 564.20 
               
               
                   
               
               
                  814 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.9 
                 5.41 
                 486.14 
               
               
                   
               
               
                  815 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.5 
                 6.35 
                 546.18 
               
               
                   
               
               
                  816 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.9 
                 5.41 
                 470.25 
               
               
                   
               
               
                  817 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 5.98 
                 456.34 
               
               
                   
               
               
                  818 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.4 
                 5.29 
                 454.24 
               
               
                   
               
               
                  819 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.4 
                 5.49 
                 462.29 
               
               
                   
               
               
                  820 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.5 
                 4.75 
                 457.34 
               
               
                   
               
               
                  821 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.5 
                 5.94 
                 514.34 
               
               
                   
               
               
                  822 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.1 
                 5.21 
                 436.26 
               
               
                   
               
               
                  823 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.7 
                 6.18 
                 496.37 
               
               
                   
               
               
                  824 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.4 
                 4.56 
                 422.22 
               
               
                   
               
               
                  825 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.5 
                 5.08 
                 408.32 
               
               
                   
               
               
                  826 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 4.45 
                 406.23 
               
               
                   
               
               
                  827 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.2 
                 4.63 
                 414.26 
               
               
                   
               
               
                  828 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.3 
                 4.01 
                 409.31 
               
               
                   
               
               
                  829 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 5.08 
                 466.36 
               
               
                   
               
               
                  830 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.7 
                 4.34 
                 388.25 
               
               
                   
               
               
                  831 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.9 
                 5.29 
                 448.36 
               
               
                   
               
               
                  832 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56 
                 5.3 
                 478.29 
               
               
                   
               
               
                  833 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.9 
                 5.7 
                 464.38 
               
               
                   
               
               
                  834 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.1 
                 5.19 
                 462.29 
               
               
                   
               
               
                  835 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.5 
                 5.31 
                 470.35 
               
               
                   
               
               
                  836 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.6 
                 4.8 
                 465.39 
               
               
                   
               
               
                  837 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.9 
                 5.67 
                 522.41 
               
               
                   
               
               
                  838 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 5.07 
                 444.33 
               
               
                   
               
               
                  839 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.5 
                 5.91 
                 504.41 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R3 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                  840 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35 + 64 
                 3.68 + 3.78 
                 423.2 
               
               
                   
               
               
                  841 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 3.7 
                 438.3 
               
               
                   
               
               
                  842 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35 + 63 
                 4.3 + 4.4 
                 446.2 
               
               
                   
               
               
                  843 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 3.71 
                 436.3 
               
               
                   
               
               
                  844 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 32 + 65 
                 3.28 + 3.34 
                 447.3 
               
               
                   
               
               
                  845 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 3.84 
                 392.3 
               
               
                   
               
               
                  846 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.18 
                 447.3 
               
               
                   
               
               
                  847 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 30 + 64 
                 3.62 + 3.64 
                 475.3 
               
               
                   
               
               
                  848 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 36 + 61 
                 4.46 + 4.61 
                 418.3 
               
               
                   
               
               
                  849 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 5.89 
                 569.1 
               
               
                   
               
               
                  850 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 6.09 
                 584.2 
               
               
                   
               
               
                  851 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 57 + 39 
                 6.55 + 6.6  
                 592.1 
               
               
                   
               
               
                  852 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 6.16 
                 582.2 
               
               
                   
               
               
                  853 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 28 + 59 
                 5.53 + 5.61 
                 593.2 
               
               
                   
               
               
                  854 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 6.35 
                 538.2 
               
               
                   
               
               
                  855 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54 + 41 
                  6.8 + 6.88 
                 593.3 
               
               
                   
               
               
                  856 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 5.96 
                 621.2 
               
               
                   
               
               
                  857 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56 + 39 
                 6.46 + 6.55 
                 564.2 
               
               
                   
               
               
                  858 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 34 + 63 
                 4.09 + 4.2  
                 451.3 
               
               
                   
               
               
                  859 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.03 
                 466.4 
               
               
                   
               
               
                  860 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33 + 64 
                 4.69 + 4.76 
                 474.3 
               
               
                   
               
               
                  861 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 27 + 70 
                 4.04 + 4.07 
                 464.4 
               
               
                   
               
               
                  862 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33 + 63 
                 3.63 + 3.71 
                 475.4 
               
               
                   
               
               
                  863 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 4.18 
                 420.4 
               
               
                   
               
               
                  864 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89 
                 4.46 
                 475.4 
               
               
                   
               
               
                  865 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 22 + 68 
                 3.94 + 3.98 
                 503.4 
               
               
                   
               
               
                  866 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35 + 62 
                  4.9 + 5.01 
                 446.4 
               
               
                   
               
               
                  867 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35 + 61 
                 4.39 + 4.52 
                 487.3 
               
               
                   
               
               
                  868 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33 + 63 
                 4.22 + 4.29 
                 502.3 
               
               
                   
               
               
                  869 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35 + 62 
                 5.08 + 5.2  
                 510.2 
               
               
                   
               
               
                  870 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 31 + 63 
                 4.26 + 4.34 
                 500.3 
               
               
                   
               
               
                  871 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33 + 62 
                 3.82 + 3.91 
                 511.3 
               
               
                   
               
               
                  872 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 31 + 62 
                 4.42 + 4.51 
                 456.3 
               
               
                   
               
               
                  873 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 29 + 64 
                 4.66 + 4.72 
                 511.4 
               
               
                   
               
               
                  874 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33 + 57 
                 4.11 + 4.2  
                 539.3 
               
               
                   
               
               
                  875 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35 + 62 
                 5.26 + 5.39 
                 482.3 
               
               
                   
               
               
                  876 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 32 + 65 
                 3.63 + 3.7  
                 467.3 
               
               
                   
               
               
                  877 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97 
                 3.69 
                 482.4 
               
               
                   
               
               
                  878 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35 + 62 
                  4.2 + 4.28 
                 490.3 
               
               
                   
               
               
                  879 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 3.69 
                 480.3 
               
               
                   
               
               
                  880 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 28 + 68 
                  3.3 + 3.33 
                 491.3 
               
               
                   
               
               
                  881 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 3.8 
                 436.3 
               
               
                   
               
               
                  882 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96 
                 4.18 
                 491.4 
               
               
                   
               
               
                  883 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 3.63 
                 519.3 
               
               
                   
               
               
                  884 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 36 + 61 
                 4.28 + 4.42 
                 462.3 
               
               
                   
               
               
                  885 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 36 + 62 
                 4.24 + 4.36 
                 517.3 
               
               
                   
               
               
                  886 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 28 + 69 
                 4.15 + 4.21 
                 532.3 
               
               
                   
               
               
                  887 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35 + 62 
                 4.84 + 4.96 
                 540.2 
               
               
                   
               
               
                  888 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33 + 64 
                 4.15 + 4.22 
                 530.3 
               
               
                   
               
               
                  889 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 32 + 63 
                 3.76 + 3.84 
                 541.3 
               
               
                   
               
               
                  890 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 32 + 63 
                 4.28 + 4.36 
                 486.3 
               
               
                   
               
               
                  891 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 24 + 73 
                 4.56 + 4.6  
                 541.3 
               
               
                   
               
               
                  892 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 31 + 59 
                 4.05 + 4.11 
                 569.3 
               
               
                   
               
               
                  893 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35 + 61 
                 4.99 + 5.14 
                 512.3 
               
               
                   
               
               
                  894 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33 + 64 
                 5.59 + 5.7  
                 576.3 
               
               
                   
               
               
                  895 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35 + 61 
                 5.29 + 5.39 
                 591.3 
               
               
                   
               
               
                  896 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 26 + 71 
                 6.32 + 6.35 
                 599.2 
               
               
                   
               
               
                  897 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 34 + 63 
                 5.41 + 5.5  
                 589.3 
               
               
                   
               
               
                  898 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35 + 61 
                 4.88 + 4.99 
                 600.3 
               
               
                   
               
               
                  899 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35 + 62 
                 5.63 + 5.72 
                 545.3 
               
               
                   
               
               
                  900 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 34 + 61 
                 5.76 + 5.86 
                 600.3 
               
               
                   
               
               
                  901 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 34 + 68 
                 5.16 + 5.28 
                 628.3 
               
               
                   
               
               
                  902 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 6.45 
                 571.3 
               
               
                   
               
               
                  903 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35 + 60 
                 3.84 + 3.93 
                 502.3 
               
               
                   
               
               
                  904 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 32 + 62 
                 3.72 + 3.79 
                 517.3 
               
               
                   
               
               
                  905 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 32 + 62 
                 4.59 + 4.68 
                 525.2 
               
               
                   
               
               
                  906 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33 + 61 
                 3.75 + 3.82 
                 515.3 
               
               
                   
               
               
                  907 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 29 + 64 
                 3.18 + 3.26 
                 526.3 
               
               
                   
               
               
                  908 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 32 + 59 
                   4 + 4.09 
                 471.3 
               
               
                   
               
               
                  909 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 32 + 60 
                 4.28 + 4.38 
                 526.3 
               
               
                   
               
               
                  910 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 34 + 56 
                 3.62 + 3.71 
                 554.3 
               
               
                   
               
               
                  911 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 31 + 63 
                 4.58 + 4.66 
                 497.3 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R1 
                 R3 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                  912 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                  6.8 + 91.2 
                  3.6 + 3.76 
                 332.22 
               
               
                   
               
               
                  913 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.1 
                 3.94 
                 352.19 
               
               
                   
               
               
                  914 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.6 
                 4.22 
                 380.22 
               
               
                   
               
               
                  915 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.6 
                 3.95 
                 382.17 
               
               
                   
               
               
                  916 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.5 
                 3.8 
                 377.19 
               
               
                   
               
               
                  917 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.2 
                 4.41 
                 430.10 
               
               
                   
               
               
                  918 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.9 
                 4.24 
                 393.18 
               
               
                   
               
               
                  919 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.1 
                 4.1 
                 397.16 
               
               
                   
               
               
                  920 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.2 
                 4.55 
                 436.05 
               
               
                   
               
               
                  921 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.8 
                 4.66 
                 392.17 
               
               
                   
               
               
                  922 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 98 
                 4.25 
                 380.22 
               
               
                   
               
               
                  923 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.1 
                 4.26 
                 400.17 
               
               
                   
               
               
                  924 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.4 
                 4.46 
                 428.21 
               
               
                   
               
               
                  925 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.8 
                 4.23 
                 430.20 
               
               
                   
               
               
                  926 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.4 
                 4.14 
                 425.17 
               
               
                   
               
               
                  927 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.3 
                 4.7 
                 478.11 
               
               
                   
               
               
                  928 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 4.56 
                 441.18 
               
               
                   
               
               
                  929 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.9 
                 4.44 
                 445.18 
               
               
                   
               
               
                  930 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.8 
                 4.9 
                 484.07 
               
               
                   
               
               
                  931 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.4 
                 5.0 
                 440.17 
               
               
                   
               
               
                  932 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 97.2 
                 4.38 
                 394.22 
               
               
                   
               
               
                  933 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.3 
                 4.48 
                 414.18 
               
               
                   
               
               
                  934 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.6 
                 4.68 
                 442.22 
               
               
                   
               
               
                  935 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91 
                 4.44 
                 444.22 
               
               
                   
               
               
                  936 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.9 
                 4.34 
                 439.18 
               
               
                   
               
               
                  937 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.2 
                 4.86 
                 492.12 
               
               
                   
               
               
                  938 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.6 
                 4.71 
                 455.2 
               
               
                   
               
               
                  939 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.8 
                 4.59 
                 459.19 
               
               
                   
               
               
                  940 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.8 
                 5.0 
                 498.09 
               
               
                   
               
               
                  941 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.9 
                 5.14 
                 454.20 
               
               
                   
               
               
                  942 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.7 
                 4.26 
                 384.17 
               
               
                   
               
               
                  943 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.7 
                 4.5 
                 404.15 
               
               
                   
               
               
                  944 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 18.6 + 76.4 
                  4.2 + 4.64 
                 432.18 
               
               
                   
               
               
                  945 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.2 
                 4.32 
                 434.16 
               
               
                   
               
               
                  946 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 4.46 
                 429.15 
               
               
                   
               
               
                  947 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.4 
                 5.08 
                 482.06 
               
               
                   
               
               
                  948 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 4.86 
                 445.16 
               
               
                   
               
               
                  949 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.2 
                 4.82 
                 449.13 
               
               
                   
               
               
                  950 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.1 
                 5.34 
                 488.03 
               
               
                   
               
               
                  951 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.7 
                 5.47 
                 444.16 
               
               
                   
               
               
                  952 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.5 
                 4.43 
                 400.13 
               
               
                   
               
               
                  953 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 4.82 
                 420.12 
               
               
                   
               
               
                  954 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 14.8 + 81.2 
                 4.38 + 4.88 
                 448.15 
               
               
                   
               
               
                  955 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.8 
                 4.64 
                 450.13 
               
               
                   
               
               
                  956 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 4.79 
                 445.11 
               
               
                   
               
               
                  957 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.4 
                 5.4 
                 498.06 
               
               
                   
               
               
                  958 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.9 
                 5.14 
                 461.12 
               
               
                   
               
               
                  959 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.5 
                 5.12 
                 465.10 
               
               
                   
               
               
                  960 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.6 
                 5.62 
                 504.00 
               
               
                   
               
               
                  961 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.4 
                 5.74 
                 460.13 
               
               
                   
               
               
                  962 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                  6.5 + 87.5 
                  4.2 + 4.54 
                 416.19 
               
               
                   
               
               
                  963 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.9 
                 4.76 
                 436.17 
               
               
                   
               
               
                  964 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 17.3 + 6.2  
                 4.5 + 4.9 
                 464.21 
               
               
                   
               
               
                  965 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.6 
                 4.64 
                 466.17 
               
               
                   
               
               
                  966 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89 
                 4.76 
                 461.16 
               
               
                   
               
               
                  967 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.1 
                 5.32 
                 514.09 
               
               
                   
               
               
                  968 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.1 
                 5.09 
                 477.19 
               
               
                   
               
               
                  969 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.5 
                 5.1 
                 481.16 
               
               
                   
               
               
                  970 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 5.56 
                 520.02 
               
               
                   
               
               
                  971 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 5.72 
                 476.17 
               
               
                   
               
               
                  972 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.6 
                 4 
                 410.16 
               
               
                   
               
               
                  973 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.7 
                 4.28 
                 430.15 
               
               
                   
               
               
                  974 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.4 
                 4.46 
                 458.19 
               
               
                   
               
               
                  975 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.9 
                 4.19 
                 460.16 
               
               
                   
               
               
                  976 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.2 
                 4.29 
                 455.12 
               
               
                   
               
               
                  977 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.4 
                 4.84 
                 508.06 
               
               
                   
               
               
                  978 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.8 
                 4.64 
                 471.15 
               
               
                   
               
               
                  979 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 46.8 
                 4.62 
                 475.14 
               
               
                   
               
               
                  980 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.4 
                 5.06 
                 514.02 
               
               
                   
               
               
                  981 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.7 
                 5.24 
                 470.16 
               
               
                   
               
               
                  982 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4.8 
                 3.54 
                 356.15 
               
               
                   
               
               
                  983 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.4 
                 4.1 
                 376.14 
               
               
                   
               
               
                  984 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79 
                 4.3 
                 404.17 
               
               
                   
               
               
                  985 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.3 
                 4.0 
                 406.13 
               
               
                   
               
               
                  986 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 12.2 
                 5.32 
                 401.11 
               
               
                   
               
               
                  987 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 46.5 
                 4.72 
                 454.04 
               
               
                   
               
               
                  988 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56.3 
                 4.49 
                 417.15 
               
               
                   
               
               
                  989 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 13.8 
                 5.52 
                 421.12 
               
               
                   
               
               
                  990 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35.3 
                 4.95 
                 460.02 
               
               
                   
               
               
                  991 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 9.1 
                 5.71 
                 416.11 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R1 
                 R3 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                  992 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.3 
                 3.33 
                 367.12 
               
               
                   
               
               
                  993 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.9 
                 3.97 
                 400.03 
               
               
                   
               
               
                  994 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.5 
                 3.64 
                 336.17 
               
               
                   
               
               
                  995 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.7 
                 3.75 
                 363.13 
               
               
                   
               
               
                  996 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.7 
                 4.88 
                 458.11 
               
               
                   
               
               
                  997 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.1 
                 4.03 
                 372.14 
               
               
                   
               
               
                  998 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.6 
                 3.37 
                 380.14 
               
               
                   
               
               
                  999 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.1 
                 4.36 
                 362.12 
               
               
                   
               
               
                 1000 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91 
                 3.32 
                 405.11 
               
               
                   
               
               
                 1001 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.8 
                 3.9 
                 397.14 
               
               
                   
               
               
                 1002 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.2 
                 4.46 
                 430.09 
               
               
                   
               
               
                 1003 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.6 
                 4.18 
                 366.23 
               
               
                   
               
               
                 1004 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 45.6 
                 4.26 
                 393.16 
               
               
                   
               
               
                 1005 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.4 
                 5.28 
                 488.17 
               
               
                   
               
               
                 1006 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67 
                 4.47 
                 402.17 
               
               
                   
               
               
                 1007 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 51.1 
                 3.86 
                 410.16 
               
               
                   
               
               
                 1008 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 57.6 
                 4.86 
                 392.16 
               
               
                   
               
               
                 1009 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.1 
                 3.92 
                 435.16 
               
               
                   
               
               
                 1010 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.7 
                 3.24 
                 399.13 
               
               
                   
               
               
                 1011 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.6 
                 3.79 
                 432.06 
               
               
                   
               
               
                 1012 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.5 
                 3.55 
                 368.16 
               
               
                   
               
               
                 1013 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.8 
                 3.62 
                 395.15 
               
               
                   
               
               
                 1014 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 4.65 
                 490.15 
               
               
                   
               
               
                 1015 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.8 
                 3.88 
                 404.17 
               
               
                   
               
               
                 1016 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.4 
                 3.3 
                 412.13 
               
               
                   
               
               
                 1017 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.7 
                 4.13 
                 394.15 
               
               
                   
               
               
                 1018 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.5 
                 3.3 
                 437.15 
               
               
                   
               
               
                 1019 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.6 
                 4.19 
                 417.10 
               
               
                   
               
               
                 1020 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.8 
                 4.76 
                 450.07 
               
               
                   
               
               
                 1021 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.9 
                 4.42 
                 386.13 
               
               
                   
               
               
                 1022 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.8 
                 4.56 
                 413.11 
               
               
                   
               
               
                 1023 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.1 
                 5.48 
                 508.13 
               
               
                   
               
               
                 1024 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.8 
                 4.79 
                 422.13 
               
               
                   
               
               
                 1025 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.3 
                 4.04 
                 430.15 
               
               
                   
               
               
                 1026 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90 
                 5.08 
                 412.10 
               
               
                   
               
               
                 1027 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.2 
                 3.95 
                 455.13 
               
               
                   
               
               
                 1028 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.6 
                 4.3 
                 435.1 
               
               
                   
               
               
                 1029 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 4.9 
                 470.1 
               
               
                   
               
               
                 1030 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.2 
                 4.6 
                 404.1 
               
               
                   
               
               
                 1031 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.2 
                 4.76 
                 431.1 
               
               
                   
               
               
                 1032 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.3 
                 5.6 
                 526.1 
               
               
                   
               
               
                 1033 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.5 
                 5 
                 440.2 
               
               
                   
               
               
                 1034 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.4 
                 4.2 
                 448.1 
               
               
                   
               
               
                 1035 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.9 
                 5.2 
                 430.1 
               
               
                   
               
               
                 1036 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.6 
                 4.1 
                 473.2 
               
               
                   
               
               
                 1037 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.4 
                 4.16 
                 447.14 
               
               
                   
               
               
                 1038 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.7 
                 4.72 
                 480.08 
               
               
                   
               
               
                 1039 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77 
                 4.39 
                 416.14 
               
               
                   
               
               
                 1040 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59.2 
                 4.5 
                 443.16 
               
               
                   
               
               
                 1041 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 16.8 
                 5.98 
                 538.12 
               
               
                   
               
               
                 1042 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59.5 
                 4.74 
                 452.16 
               
               
                   
               
               
                 1043 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74 
                 4.02 
                 460.16 
               
               
                   
               
               
                 1044 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 26.3 
                 5.52 
                 442.13 
               
               
                   
               
               
                 1045 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91 
                 3.82 
                 485.17 
               
               
                   
               
               
                 1046 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.8 
                 5.09 
                 507.19 
               
               
                   
               
               
                 1047 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.5 
                 5.52 
                 540.09 
               
               
                   
               
               
                 1048 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86 
                 5.06 
                 476.21 
               
               
                   
               
               
                 1049 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.6 
                 5.22 
                 503.21 
               
               
                   
               
               
                 1050 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.3 
                 6.14 
                 598.15 
               
               
                   
               
               
                 1051 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.9 
                 5.38 
                 512.22 
               
               
                   
               
               
                 1052 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.3 
                 4.68 
                 520.19 
               
               
                   
               
               
                 1053 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.3 
                 5.66 
                 502.20 
               
               
                   
               
               
                 1054 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 4.92 
                 545.17 
               
               
                   
               
               
                 1055 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.1 
                 4.34 
                 445.16 
               
               
                   
               
               
                 1056 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.5 
                 4.77 
                 478.10 
               
               
                   
               
               
                 1057 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.9 
                 4.46 
                 414.17 
               
               
                   
               
               
                 1058 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.2 
                 4.56 
                 441.15 
               
               
                   
               
               
                 1059 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.8 
                 5.56 
                 536.11 
               
               
                   
               
               
                 1060 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.1 
                 4.73 
                 450.19 
               
               
                   
               
               
                 1061 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.4 
                 4.12 
                 458.20 
               
               
                   
               
               
                 1062 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.3 
                 5.13 
                 440.16 
               
               
                   
               
               
                 1063 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.1 
                 4.22 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R1 
                 R3 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                 1064 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.6 
                 3.52 
                 338.12 
               
               
                   
               
               
                 1065 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.4 
                 3.44 
                 383.09 
               
               
                   
               
               
                 1066 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.3 
                 4.25 
                 422.10 
               
               
                   
               
               
                 1067 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.9 
                 4.04 
                 416.04 
               
               
                   
               
               
                 1068 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.5 
                 4.4 
                 444.18 
               
               
                   
               
               
                 1069 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.1 
                 4.83 
                 474.13 
               
               
                   
               
               
                 1070 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.6 
                 4.34 
                 402.16 
               
               
                   
               
               
                 1071 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.8 
                 4.37 
                 378.14 
               
               
                   
               
               
                 1072 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.5 
                 4.77 
                 442.06 
               
               
                   
               
               
                 1073 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.4 
                 4.72 
                 405.12 
               
               
                   
               
               
                 1074 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.5 
                 3.02 
                 340.15 
               
               
                   
               
               
                 1075 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.5 
                 2.98 
                 385.10 
               
               
                   
               
               
                 1076 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.7 
                 3.9 
                 424.12 
               
               
                   
               
               
                 1077 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.8 
                 3.62 
                 418.04 
               
               
                   
               
               
                 1078 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.8 
                 4.09 
                 446.18 
               
               
                   
               
               
                 1079 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.1 
                 4.6 
                 476.12 
               
               
                   
               
               
                 1080 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.5 
                 3.98 
                 404.16 
               
               
                   
               
               
                 1081 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.2 
                 3.87 
                 380.13 
               
               
                   
               
               
                 1082 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.3 
                 4.36 
                 444.10 
               
               
                   
               
               
                 1083 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.6 
                 4.24 
                 407.13 
               
               
                   
               
               
                 1084 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.4 
                 4.24 
                 414.15 
               
               
                   
               
               
                 1085 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.8 
                 4.21 
                 459.17 
               
               
                   
               
               
                 1086 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.2 
                 4.89 
                 498.19 
               
               
                   
               
               
                 1087 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.8 
                 4.71 
                 492.12 
               
               
                   
               
               
                 1088 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.1 
                 4.9 
                 520.21 
               
               
                   
               
               
                 1089 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.3 
                 5.45 
                 550.17 
               
               
                   
               
               
                 1090 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.9 
                 4.9 
                 478.24 
               
               
                   
               
               
                 1091 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.1 
                 5.08 
                 454.19 
               
               
                   
               
               
                 1092 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78 
                 5.38 
                 518.14 
               
               
                   
               
               
                 1093 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.5 
                 5.38 
                 481.21 
               
               
                   
               
               
                 1094 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 37.5 
                 3.36 
                 386.14 
               
               
                   
               
               
                 1095 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 57.1 
                 3.35 
                 431.14 
               
               
                   
               
               
                 1096 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 44 
                 3.78 
                 470.17 
               
               
                   
               
               
                 1097 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 42 
                 3.62 
                 464.09 
               
               
                   
               
               
                 1098 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 38.8 
                 4.14 
                 492.21 
               
               
                   
               
               
                 1099 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 45.2 
                 3.98 
                 522.14 
               
               
                   
               
               
                 1100 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33.4 
                 3.99 
                 450.20 
               
               
                   
               
               
                 1101 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 44.7 
                 3.68 
                 426.14 
               
               
                   
               
               
                 1102 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33.4 
                 4.08 
                 490.12 
               
               
                   
               
               
                 1103 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 42.4 
                 3.67 
                 453.17 
               
               
                   
               
               
                 1104 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.6 
                 4.23 
                 390.14 
               
               
                   
               
               
                 1105 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.9 
                 4.1 
                 439.1 
               
               
                   
               
               
                 1106 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.1 
                 5 
                 474.13 
               
               
                   
               
               
                 1107 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 4.85 
                 468.04 
               
               
                   
               
               
                 1108 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.5 
                 5.04 
                 496.18 
               
               
                   
               
               
                 1109 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 5.5 
                 526.13 
               
               
                   
               
               
                 1110 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 5.1 
                 454.17 
               
               
                   
               
               
                 1111 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 5.1 
                 430.10 
               
               
                   
               
               
                 1112 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 5.48 
                 494.08 
               
               
                   
               
               
                 1113 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 5.1 
                 457.18 
               
               
                   
               
               
                 1114 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.8 
                 4.6 
                 406.10 
               
               
                   
               
               
                 1115 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.6 
                 4.5 
                 451.03 
               
               
                   
               
               
                 1116 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.1 
                 5.2 
                 490.10 
               
               
                   
               
               
                 1117 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.5 
                 5.1 
                 483.99 
               
               
                   
               
               
                 1118 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.54 
                 5.29 
                 512.13 
               
               
                   
               
               
                 1119 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.2 
                 5.6 
                 542.1 
               
               
                   
               
               
                 1120 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 5.38 
                 470.15 
               
               
                   
               
               
                 1121 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.4 
                 5.3 
                 445.94 
               
               
                   
               
               
                 1122 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.7 
                 5.7 
                 510.05 
               
               
                   
               
               
                 1123 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.3 
                 5.3 
                 473.04 
               
               
                   
               
               
                 1124 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.5 
                 4.06 
                 400.12 
               
               
                   
               
               
                 1125 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.1 
                 4.13 
                 445.13 
               
               
                   
               
               
                 1126 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.9 
                 4.81 
                 484.15 
               
               
                   
               
               
                 1127 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.8 
                 4.56 
                 478.09 
               
               
                   
               
               
                 1128 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.4 
                 4.76 
                 506.20 
               
               
                   
               
               
                 1129 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.6 
                 5.36 
                 536.12 
               
               
                   
               
               
                 1130 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.7 
                 4.78 
                 464.18 
               
               
                   
               
               
                 1131 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84 
                 4.94 
                 440.15 
               
               
                   
               
               
                 1132 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.3 
                 5.38 
                 504.10 
               
               
                   
               
               
                 1133 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.4 
                 5.16 
                 467.17 
               
               
                   
               
               
                 1134 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.7 
                 3.76 
                 446.16 
               
               
                   
               
               
                 1135 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89 
                 3.77 
                 491.14 
               
               
                   
               
               
                 1136 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.1 
                 4.4 
                 530.13 
               
               
                   
               
               
                 1137 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.6 
                 4.21 
                 524.08 
               
               
                   
               
               
                 1138 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76 
                 4.52 
                 552.19 
               
               
                   
               
               
                 1139 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.6 
                 4.98 
                 582.12 
               
               
                   
               
               
                 1140 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.1 
                 4.44 
                 510.21 
               
               
                   
               
               
                 1141 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.3 
                 4.6 
                 486.19 
               
               
                   
               
               
                 1142 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 1.5 
                 5.07 
                 550.12 
               
               
                   
               
               
                 1143 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84 
                 4.75 
                 513.16 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R1 
                 R3 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                 1144 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75 
                 4.48 
                 300.16 
               
               
                   
               
               
                 1145 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 4.89 
                 348.16 
               
               
                   
               
               
                 1146 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.7 
                 4.72 
                 354.09 
               
               
                   
               
               
                 1147 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89 
                 4.96 
                 398.01 
               
               
                   
               
               
                 1148 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87 
                 4.37 
                 345.18 
               
               
                   
               
               
                 1149 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90 
                 5.4 
                 396.1 
               
               
                   
               
               
                 1150 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89 
                 5.9 
                 448.2 
               
               
                   
               
               
                 1151 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85 
                 5 
                 404 
               
               
                   
               
               
                 1152 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85 
                 4.96 
                 360.10 
               
               
                   
               
               
                 1153 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91 
                 4.39 
                 417.14 
               
               
                   
               
               
                 1154 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 5.14 
                 366.21 
               
               
                   
               
               
                 1155 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 5.52 
                 414.17 
               
               
                   
               
               
                 1156 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95 
                 5.37 
                 420.13 
               
               
                   
               
               
                 1157 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 5.6 
                 464.08 
               
               
                   
               
               
                 1158 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 5 
                 411.2 
               
               
                   
               
               
                 1159 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91 
                 6.04 
                 462.19 
               
               
                   
               
               
                 1160 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.5 
                 6.4 
                 514.2 
               
               
                   
               
               
                 1161 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.6 
                 5.7 
                 470.1 
               
               
                   
               
               
                 1162 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.8 
                 5.6 
                 426.14 
               
               
                   
               
               
                 1163 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.4 
                 5.02 
                 483.21 
               
               
                   
               
               
                 1164 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.3 
                 5.55 
                 420.10 
               
               
                   
               
               
                 1165 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.2 
                 5.81 
                 468.10 
               
               
                   
               
               
                 1166 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.7 
                 5.6 
                 474.06 
               
               
                   
               
               
                 1167 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.9 
                 5.8 
                 517.97 
               
               
                   
               
               
                 1168 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.2 
                 5.18 
                 465.06 
               
               
                   
               
               
                 1169 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 6.25 
                 516.10 
               
               
                   
               
               
                 1170 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.4 
                 6.52 
                 568.2 
               
               
                   
               
               
                 1171 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.6 
                 5.9 
                 524.0 
               
               
                   
               
               
                 1172 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.9 
                 5.81 
                 480.07 
               
               
                   
               
               
                 1173 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.9 
                 5.25 
                 537.09 
               
               
                   
               
               
                 1174 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.4 
                 5.24 
                 486.16 
               
               
                   
               
               
                 1175 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 96.8 
                 5.36 
                 402.15 
               
               
                   
               
               
                 1176 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.4 
                 5.66 
                 450.19 
               
               
                   
               
               
                 1177 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.3 
                 5.48 
                 456.12 
               
               
                   
               
               
                 1178 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.3 
                 5.7 
                 500.08 
               
               
                   
               
               
                 1179 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.7 
                 5.12 
                 447.15 
               
               
                   
               
               
                 1180 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.9 
                 6.12 
                 498.21 
               
               
                   
               
               
                 1181 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.1 
                 6.5 
                 550.3 
               
               
                   
               
               
                 1182 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 5.7 
                 506.0 
               
               
                   
               
               
                 1183 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.9 
                 5.74 
                 462.15 
               
               
                   
               
               
                 1184 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.4 
                 5.13 
                 519.17 
               
               
                   
               
               
                 1185 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.6 
                 3.52 
                 346.19 
               
               
                   
               
               
                 1186 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.5 
                 4.5 
                 394.17 
               
               
                   
               
               
                 1187 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.2 
                 4.58 
                 400.10 
               
               
                   
               
               
                 1188 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.6 
                 4.86 
                 444.09 
               
               
                   
               
               
                 1189 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.5 
                 5.3 
                 442.17 
               
               
                   
               
               
                 1190 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.8 
                 5 
                 406.13 
               
               
                   
               
               
                 1191 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.5 
                 4.1 
                 463.19 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R5 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                 1192 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 28.3 
                 3.61 
                 373.15 
               
               
                   
               
               
                 1193 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.3 
                 2.55 
                 396.15 
               
               
                   
               
               
                 1194 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.8 
                 3.58 
                 425.13 
               
               
                   
               
               
                 1195 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 51.9 
                 3.47 
                 387.07 
               
               
                   
               
               
                 1196 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.8 
                 4.43 
                 471.21 
               
               
                   
               
               
                 1197 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.4 
                 2.38 
                 399.15 
               
               
                   
               
               
                 1198 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 42.6 
                 3.11 
                 474.14 
               
               
                   
               
               
                 1199 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 45.3 
                 4.39 
                 457.18 
               
               
                   
               
               
                 1200 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64 
                 4.62 
                 485.21 
               
               
                   
               
               
                 1201 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 55.1 
                 4.09 
                 429.12 
               
               
                   
               
               
                 1202 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75 
                 4.22 
                 449.13 
               
               
                   
               
               
                 1203 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.9 
                 3.64 
                 417.11 
               
               
                   
               
               
                 1204 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 31.7 + 17.3 
                 4.65 + 4.8  
                 429.24 
               
               
                   
               
               
                 1205 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 41.8 
                 3.86 
                 407.14 
               
               
                   
               
               
                 1206 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.8 
                 4.58 
                 487.20 
               
               
                   
               
               
                 1207 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33.2 
                 4.31 
                 415.20 
               
               
                   
               
               
                 1208 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.9 
                 3.29 
                 438.21 
               
               
                   
               
               
                 1209 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58 
                 4.29 
                 467.18 
               
               
                   
               
               
                 1210 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 51.9 
                 4.21 
                 429.15 
               
               
                   
               
               
                 1211 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70 
                 5.03 
                 513.24 
               
               
                   
               
               
                 1212 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 22.9 
                 3.17 
                 441.19 
               
               
                   
               
               
                 1213 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.8 
                 3.81 
                 516.16 
               
               
                   
               
               
                 1214 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35.4 
                 5.03 
                 499.23 
               
               
                   
               
               
                 1215 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64 
                 5.18 
                 527.25 
               
               
                   
               
               
                 1216 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.2 
                 4.71 
                 471.19 
               
               
                   
               
               
                 1217 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.5 
                 4.84 
                 491.18 
               
               
                   
               
               
                 1218 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.6 
                 4.35 
                 459.16 
               
               
                   
               
               
                 1219 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 28.7 + 14.2 
                 5.27 + 5.4  
                 471.30 
               
               
                   
               
               
                 1220 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.9 
                 4.52 
                 449.21 
               
               
                   
               
               
                 1221 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.1 
                 5.17 
                 529.21 
               
               
                   
               
               
                 1222 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 49.7 
                 4.55 
                 423.19 
               
               
                   
               
               
                 1223 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.8 
                 3.41 
                 446.17 
               
               
                   
               
               
                 1224 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.2 
                 4.48 
                 475.15 
               
               
                   
               
               
                 1225 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.3 
                 4.42 
                 437.12 
               
               
                   
               
               
                 1226 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.6 
                 5.24 
                 521.17 
               
               
                   
               
               
                 1227 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 49.1 
                 3.29 
                 449.20 
               
               
                   
               
               
                 1228 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.2 
                 4 
                 524.15 
               
               
                   
               
               
                 1229 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.7 
                 5.22 
                 507.20 
               
               
                   
               
               
                 1230 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75 
                 5.42 
                 535.20 
               
               
                   
               
               
                 1231 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78 
                 4.93 
                 479.13 
               
               
                   
               
               
                 1232 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.1 
                 5.04 
                 499.16 
               
               
                   
               
               
                 1233 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.6 
                 4.56 
                 467.13 
               
               
                   
               
               
                 1234 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   45 + 24.6 
                 5.53 + 5.7  
                 479.26 
               
               
                   
               
               
                 1235 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77 
                 4.75 
                 457.18 
               
               
                   
               
               
                 1236 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.4 
                 5.41 
                 537.18 
               
               
                   
               
               
                 1237 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 47.7 
                 4.38 
                 407.12 
               
               
                   
               
               
                 1238 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.3 
                 3.27 
                 430.12 
               
               
                   
               
               
                 1239 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.2 
                 4.35 
                 459.10 
               
               
                   
               
               
                 1240 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.1 
                 4.27 
                 421.06 
               
               
                   
               
               
                 1241 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.8 
                 5.13 
                 505.13 
               
               
                   
               
               
                 1242 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 24 
                 3.17 
                 433.11 
               
               
                   
               
               
                 1243 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.2 
                 3.86 
                 508.08 
               
               
                   
               
               
                 1244 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 43 
                 5.16 
                 491.08 
               
               
                   
               
               
                 1245 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.8 
                 5.38 
                 519.12 
               
               
                   
               
               
                 1246 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.9 
                 4.85 
                 463.05 
               
               
                   
               
               
                 1247 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.2 
                 4.96 
                 483.10 
               
               
                   
               
               
                 1248 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.9 
                 4.45 
                 451.07 
               
               
                   
               
               
                 1249 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 42.6 + 23.5 
                 5.42 + 5.6  
                 463.20 
               
               
                   
               
               
                 1250 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70 
                 4.65 
                 441.11 
               
               
                   
               
               
                 1251 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72 
                 5.36 
                 521.12 
               
               
                   
               
               
                 1252 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 28.2 
                 4.96 
                 441.14 
               
               
                   
               
               
                 1253 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.8 
                 3.69 
                 464.14 
               
               
                   
               
               
                 1254 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 51 
                 4.86 
                 493.14 
               
               
                   
               
               
                 1255 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.5 
                 4.79 
                 455.08 
               
               
                   
               
               
                 1256 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.2 
                 5.55 
                 539.16 
               
               
                   
               
               
                 1257 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 27.2 
                 3.59 
                 467.16 
               
               
                   
               
               
                 1258 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 38.6 
                 4.38 
                 542.12 
               
               
                   
               
               
                 1259 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 49.4 
                 5.53 
                 525.16 
               
               
                   
               
               
                 1260 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.6 
                 5.73 
                 553.20 
               
               
                   
               
               
                 1261 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.7 
                 5.27 
                 497.13 
               
               
                   
               
               
                 1262 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.8 
                 5.34 
                 517.12 
               
               
                   
               
               
                 1263 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78 
                 4.92 
                 485.13 
               
               
                   
               
               
                 1264 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 28.5 + 14.4 
                 5.87 + 6.0  
                 497.26 
               
               
                   
               
               
                 1265 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.5 
                 5.13 
                 475.16 
               
               
                   
               
               
                 1266 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.7 
                 5.73 
                 555.14 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R5 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                 1267 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60 
                 3.86 
                 439.18 
               
               
                   
               
               
                 1268 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.1 
                 2.89 
                 478.24 
               
               
                   
               
               
                 1269 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.1 
                 3.83 
                 389.20 
               
               
                   
               
               
                 1270 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.3 
                 2.41 
                 396.14 
               
               
                   
               
               
                 1271 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94 
                 2.33 
                 418.20 
               
               
                   
               
               
                 1272 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.3 
                 4.05 
                 533.17 
               
               
                   
               
               
                 1273 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93 
                 4.33 
                 485.23 
               
               
                   
               
               
                 1274 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.5 
                 4.27 
                 471.22 
               
               
                   
               
               
                 1275 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.4 
                 3.94 
                 423.20 
               
               
                   
               
               
                 1276 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 4.07 
                 487.10 
               
               
                   
               
               
                 1277 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.3 
                 4.09 
                 463.16 
               
               
                   
               
               
                 1278 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.6 
                 2.9 
                 430.20 
               
               
                   
               
               
                 1279 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.7 
                 3.69 
                 431.14 
               
               
                   
               
               
                 1280 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.6 
                 4.37 
                 471.21 
               
               
                   
               
               
                 1281 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.4 
                 4.51 
                 501.20 
               
               
                   
               
               
                 1282 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.1 
                 4.16 
                 463.09 
               
               
                   
               
               
                 1283 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.6 
                 5.58 
                 541.11 
               
               
                   
               
               
                 1284 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.4 
                 4.23 
                 580.17 
               
               
                   
               
               
                 1285 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.6 
                 5.63 
                 491.16 
               
               
                   
               
               
                 1286 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.5 
                 4.03 
                 498.13 
               
               
                   
               
               
                 1287 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.5 
                 3.91 
                 520.13 
               
               
                   
               
               
                 1288 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.2 
                 5.61 
                 635.14 
               
               
                   
               
               
                 1289 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.3 
                 5.9 
                 587.14 
               
               
                   
               
               
                 1290 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.9 
                 5.86 
                 573.11 
               
               
                   
               
               
                 1291 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90 
                 5.66 
                 525.14 
               
               
                   
               
               
                 1292 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.9 
                 5.73 
                 589.02 
               
               
                   
               
               
                 1293 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.2 
                 5.69 
                 565.07 
               
               
                   
               
               
                 1294 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.4 
                 4.72 
                 532.13 
               
               
                   
               
               
                 1295 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.3 
                 5.44 
                 533.08 
               
               
                   
               
               
                 1296 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.1 
                 5.95 
                 573.11 
               
               
                   
               
               
                 1297 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.1 
                 6.06 
                 603.16 
               
               
                   
               
               
                 1298 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.3 
                 5.79 
                 565.00 
               
               
                   
               
               
                 1299 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.6 
                 4.65 
                 515.20 
               
               
                   
               
               
                 1300 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.9 
                 3.63 
                 554.24 
               
               
                   
               
               
                 1301 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.9 
                 4.67 
                 465.23 
               
               
                   
               
               
                 1302 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.4 
                 3.41 
                 472.20 
               
               
                   
               
               
                 1303 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.7 
                 3.31 
                 494.23 
               
               
                   
               
               
                 1304 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.2 
                 4.79 
                 609.20 
               
               
                   
               
               
                 1305 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.5 
                 5.11 
                 561.20 
               
               
                   
               
               
                 1306 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.2 
                 5.11 
                 547.19 
               
               
                   
               
               
                 1307 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.8 
                 4.75 
                 499.23 
               
               
                   
               
               
                 1308 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89 
                 4.89 
                 539.15 
               
               
                   
               
               
                 1309 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.9 
                 3.76 
                 506.23 
               
               
                   
               
               
                 1310 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.5 
                 4.59 
                 507.17 
               
               
                   
               
               
                 1311 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.8 
                 5.16 
                 547.20 
               
               
                   
               
               
                 1312 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 1.5 
                 5.6 
                 577.22 
               
               
                   
               
               
                 1313 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.7 
                 4.99 
                 539.10 
               
               
                   
               
               
                 1314 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.3 
                 4.81 
                 545.20 
               
               
                   
               
               
                 1315 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.7 
                 3.82 
                 584.25 
               
               
                   
               
               
                 1316 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.6 
                 4.81 
                 495.24 
               
               
                   
               
               
                 1317 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91 
                 3.63 
                 502.20 
               
               
                   
               
               
                 1318 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.2 
                 3.54 
                 524.24 
               
               
                   
               
               
                 1319 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.4 
                 4.91 
                 639.22 
               
               
                   
               
               
                 1320 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.7 
                 5.21 
                 591.23 
               
               
                   
               
               
                 1321 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90 
                 5.19 
                 577.22 
               
               
                   
               
               
                 1322 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.9 
                 4.87 
                 529.22 
               
               
                   
               
               
                 1323 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.4 
                 5 
                 593.12 
               
               
                   
               
               
                 1324 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.5 
                 5.01 
                 569.16 
               
               
                   
               
               
                 1325 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.7 
                 4 
                 536.23 
               
               
                   
               
               
                 1326 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.6 
                 4.73 
                 537.18 
               
               
                   
               
               
                 1327 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.6 
                 5.24 
                 577.24 
               
               
                   
               
               
                 1328 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.7 
                 5.33 
                 607.24 
               
               
                   
               
               
                 1329 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.6 
                 5.1 
                 569.10 
               
               
                   
               
               
                 1330 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.1 
                 4.17 
                 467.23 
               
               
                   
               
               
                 1331 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 3.23 
                 506.28 
               
               
                   
               
               
                 1332 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.3 
                 4.14 
                 417.24 
               
               
                   
               
               
                 1333 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.9 
                 2.95 
                 424.19 
               
               
                   
               
               
                 1334 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.8 
                 2.87 
                 446.24 
               
               
                   
               
               
                 1335 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.7 
                 4.31 
                 561.19 
               
               
                   
               
               
                 1336 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.5 
                 4.58 
                 513.25 
               
               
                   
               
               
                 1337 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.3 
                 4.54 
                 499.24 
               
               
                   
               
               
                 1338 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.3 
                 4.24 
                 451.23 
               
               
                   
               
               
                 1339 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.6 
                 4.37 
                 515.12 
               
               
                   
               
               
                 1340 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.7 
                 4.37 
                 491.18 
               
               
                   
               
               
                 1341 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.3 
                 3.34 
                 458.25 
               
               
                   
               
               
                 1342 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.8 
                 4.05 
                 459.19 
               
               
                   
               
               
                 1343 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.9 
                 4.63 
                 499.25 
               
               
                   
               
               
                 1344 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.6 
                 4.75 
                 529.24 
               
               
                   
               
               
                 1345 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.9 
                 4.45 
                 491.13 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R5 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                 1346 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56.9 + 24.5 
                 4.07 + 4.2  
                 417.23 
               
               
                   
               
               
                 1347 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.6 + 24.4 
                 4.98 + 5.1  
                 526.30 
               
               
                   
               
               
                 1348 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.4 + 25.1 
                 3.96 + 4.1  
                 430.25 
               
               
                   
               
               
                 1349 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.5 
                 3.44 
                 490.37 
               
               
                   
               
               
                 1350 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.4 + 27.8 
                 4.9 + 5.0 
                 503.31 
               
               
                   
               
               
                 1351 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.5 + 25.5 
                 5.6 + 5.7 
                 536.35 
               
               
                   
               
               
                 1352 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.8 
                 3.3 
                 509.30 
               
               
                   
               
               
                 1353 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.1 + 29.8 
                 5.02 + 5.1  
                 537.26 
               
               
                   
               
               
                 1354 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.8 + 32.2 
                 5.37 + 5.5  
                 543.32 
               
               
                   
               
               
                 1355 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59.6 + 31.5 
                 5.24 + 5.3  
                 545.30 
               
               
                   
               
               
                 1356 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.6 + 24.8 
                 4.69 + 4.8  
                 527.31 
               
               
                   
               
               
                 1357 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.7 
                 3.8 
                 536.36 
               
               
                   
               
               
                 1358 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.5 
                 3.8 
                 528.38 
               
               
                   
               
               
                 1359 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   58 + 25.2 
                 4.12 + 4.3  
                 417.27 
               
               
                   
               
               
                 1360 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.1 + 24.5 
                 5.22 + 5.3  
                 529.31 
               
               
                   
               
               
                 1361 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.8 + 23.1 
                 5.12 + 5.2  
                 535.19 
               
               
                   
               
               
                 1362 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.9 + 21.6 
                 5.46 + 5.5  
                 535.23 
               
               
                   
               
               
                 1363 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.4 
                 6.06 
                 644.33 
               
               
                   
               
               
                 1364 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.7 
                 5.31 
                 548.24 
               
               
                   
               
               
                 1365 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.3 
                 4.5 
                 608.34 
               
               
                   
               
               
                 1366 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 95.2 
                 6.06 
                 621.27 
               
               
                   
               
               
                 1367 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.9 
                 6.6 
                 654.4 
               
               
                   
               
               
                 1368 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.2 
                 4.41 
                 627.29 
               
               
                   
               
               
                 1369 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 6.12 
                 655.27 
               
               
                   
               
               
                 1370 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.9 
                 6.4 
                 661.33 
               
               
                   
               
               
                 1371 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.2 
                 6.3 
                 663.32 
               
               
                   
               
               
                 1372 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.3 
                 5.9 
                 645.32 
               
               
                   
               
               
                 1373 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.5 
                 4.7 
                 654.4 
               
               
                   
               
               
                 1374 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.8 
                 4.7 
                 646.38 
               
               
                   
               
               
                 1375 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.8 
                 5.53 
                 535.23 
               
               
                   
               
               
                 1376 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.2 
                 6.28 
                 647.32 
               
               
                   
               
               
                 1377 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.6 
                 6.25 
                 653.22 
               
               
                   
               
               
                 1378 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   63 + 26.1 
                 3.98 + 4.2  
                 441.30 
               
               
                   
               
               
                 1379 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.5 + 28   
                 4.8 + 5.0 
                 550.36 
               
               
                   
               
               
                 1380 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.1 + 26.9 
                 3.93 + 4.1  
                 454.30 
               
               
                   
               
               
                 1381 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56.6 + 30.1 
                 3.54 + 3.6  
                 514.40 
               
               
                   
               
               
                 1382 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.8 + 30.3 
                 4.64 + 4.9  
                 527.34 
               
               
                   
               
               
                 1383 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.3 + 28.3 
                 5.33 + 5.6  
                 560.39 
               
               
                   
               
               
                 1384 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.5 + 24.8 
                 3.5 + 3.6 
                 533.35 
               
               
                   
               
               
                 1385 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.9 + 27.5 
                 4.77 + 5.0  
                 561.29 
               
               
                   
               
               
                 1386 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 48.5 + 20.8 
                 5.08 + 5.3  
                 567.36 
               
               
                   
               
               
                 1387 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.2 + 27.5 
                 4.98 + 5.2  
                 569.33 
               
               
                   
               
               
                 1388 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.4 + 22.7 
                 4.5 + 4.7 
                 551.36 
               
               
                   
               
               
                 1389 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.1 + 26.4 
                 3.92 + 4.0  
                 560.38 
               
               
                   
               
               
                 1390 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.6 + 26.1 
                 3.92 + 4.1  
                 552.43 
               
               
                   
               
               
                 1391 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   64 + 27.3 
                 4.01 + 4.2  
                 441.30 
               
               
                   
               
               
                 1392 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.2 + 28.9 
                 4.96 + 5.2  
                 553.35 
               
               
                   
               
               
                 1393 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.8 + 26.6 
                 4.84 + 5.0  
                 559.23 
               
               
                   
               
               
                 1394 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59.4 + 26.3 
                 3.95 + 4.1  
                 445.26 
               
               
                   
               
               
                 1395 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.7 + 28.7 
                 4.89 + 5.1  
                 554.28 
               
               
                   
               
               
                 1396 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   62 + 27.9 
                 3.9 + 4.1 
                 458.27 
               
               
                   
               
               
                 1397 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.9 + 28.7 
                 3.48 + 3.5  
                 518.35 
               
               
                   
               
               
                 1398 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.9 + 29.3 
                 4.75 + 5.0  
                 531.28 
               
               
                   
               
               
                 1399 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.2 + 28.4 
                 5.46 + 5.7  
                 564.32 
               
               
                   
               
               
                 1400 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.3 + 30.4 
                 3.39 + 3.5  
                 537.30 
               
               
                   
               
               
                 1401 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.8 + 28.3 
                 4.88 + 5.0  
                 565.23 
               
               
                   
               
               
                 1402 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.5 + 27.9 
                 5.2 + 5.4 
                 571.28 
               
               
                   
               
               
                 1403 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.2 + 29.5 
                 5.09 + 5.3  
                 573.28 
               
               
                   
               
               
                 1404 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.6 + 26.7 
                 4.54 + 4.7  
                 555.30 
               
               
                   
               
               
                 1405 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59.2 + 31.8 
                 3.86 + 4.0  
                 564.32 
               
               
                   
               
               
                 1406 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59.3 + 31.2 
                 3.86 + 4.0  
                 556.37 
               
               
                   
               
               
                 1407 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 49.3 + 21.7 
                   4 + 4.2 
                 445.26 
               
               
                   
               
               
                 1408 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.4 + 29.7 
                 5.07 + 5.3  
                 557.28 
               
               
                   
               
               
                 1409 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.7 + 27.9 
                 4.96 + 5.1  
                 563.20 
               
               
                   
               
               
                 1410 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.4 + 25.4 
                 5.24 + 5.4  
                 552.27 
               
               
                   
               
               
                 1411 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.6 + 28.1 
                 5.91 + 6.0  
                 661.33 
               
               
                   
               
               
                 1412 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.5 + 30.2 
                 5.14 + 5.2  
                 565.25 
               
               
                   
               
               
                 1413 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.2 
                 4.43 
                 625.36 
               
               
                   
               
               
                 1414 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.9 + 31.9 
                 5.88 + 6.0  
                 638.30 
               
               
                   
               
               
                 1415 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.1 + 31.2 
                 6.47 + 6.6  
                 671.37 
               
               
                   
               
               
                 1416 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.3 
                 4.34 
                 644.35 
               
               
                   
               
               
                 1417 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.6 + 25.7 
                 5.96 + 6.0  
                 672.28 
               
               
                   
               
               
                 1418 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.1 + 25.4 
                 6.25 + 6.3  
                 678.35 
               
               
                   
               
               
                 1419 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   63 + 27.5 
                 6.13 + 6.2  
                 680.32 
               
               
                   
               
               
                 1420 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54.7 + 29.8 
                 5.75 + 5.8  
                 662.33 
               
               
                   
               
               
                 1421 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.7 
                 4.71 
                 671.38 
               
               
                   
               
               
                 1422 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.3 
                 4.72 
                 663.41 
               
               
                   
               
               
                 1423 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                   49 + 23.9 
                 5.34 + 5.4  
                 552.26 
               
               
                   
               
               
                 1424 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.1 + 27.2 
                 6.18 + 6.2  
                 664.34 
               
               
                   
               
               
                 1425 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.3 + 27.3 
                 6.13 + 6.2  
                 670.25 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R5 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                 1426 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.4 
                 4.58 
                 463.27 
               
               
                   
               
               
                 1427 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 53.4 
                 4.48 
                 471.23 
               
               
                   
               
               
                 1428 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.2 
                 3.67 
                 526.29 
               
               
                   
               
               
                 1429 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86 
                 4.58 
                 542.25 
               
               
                   
               
               
                 1430 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.9 
                 4.98 
                 546.21 
               
               
                   
               
               
                 1431 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 42.9 
                 3.26 
                 494.27 
               
               
                   
               
               
                 1432 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.4 
                 4.14 
                 522.26 
               
               
                   
               
               
                 1433 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.2 
                 4.72 
                 570.25 
               
               
                   
               
               
                 1434 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.1 
                 4.04 
                 530.22 
               
               
                   
               
               
                 1435 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 45.6 
                 3.16 
                 464.25 
               
               
                   
               
               
                 1436 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.6 
                 4.4 
                 475.20 
               
               
                   
               
               
                 1437 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.2 
                 4.96 
                 541.18 
               
               
                   
               
               
                 1438 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.2 
                 3.88 
                 554.28 
               
               
                   
               
               
                 1439 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.5 
                 4.39 
                 437.23 
               
               
                   
               
               
                 1440 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33.8 
                 5.34 
                 593.17 
               
               
                   
               
               
                 1441 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 9.5 
                 4.7 
                 463.24 
               
               
                   
               
               
                 1442 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.8 
                 5.11 
                 499.20 
               
               
                   
               
               
                 1443 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 46.9 
                 4.98 
                 507.17 
               
               
                   
               
               
                 1444 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.9 
                 3.88 
                 562.19 
               
               
                   
               
               
                 1445 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.6 
                 4.95 
                 578.19 
               
               
                   
               
               
                 1446 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.9 
                 5.3 
                 582.14 
               
               
                   
               
               
                 1447 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 49 
                 3.45 
                 530.19 
               
               
                   
               
               
                 1448 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.4 
                 4.62 
                 558.18 
               
               
                   
               
               
                 1449 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83 
                 5.06 
                 606.20 
               
               
                   
               
               
                 1450 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.9 
                 4.42 
                 566.15 
               
               
                   
               
               
                 1451 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 40.7 
                 3.5 
                 500.19 
               
               
                   
               
               
                 1452 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.1 
                 4.87 
                 511.13 
               
               
                   
               
               
                 1453 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.4 
                 5.33 
                 577.13 
               
               
                   
               
               
                 1454 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.6 
                 4.08 
                 590.24 
               
               
                   
               
               
                 1455 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54.9 
                 4.92 
                 473.21 
               
               
                   
               
               
                 1456 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 43 
                 5.66 
                 629.13 
               
               
                   
               
               
                 1457 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 17.2 
                 5.2 
                 499.20 
               
               
                   
               
               
                 1458 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.6 
                 4.3 
                 479.20 
               
               
                   
               
               
                 1459 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 55.3 
                 4.2 
                 487.18 
               
               
                   
               
               
                 1460 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.2 
                 3.32 
                 542.22 
               
               
                   
               
               
                 1461 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87 
                 4.22 
                 558.19 
               
               
                   
               
               
                 1462 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.9 
                 4.64 
                 562.14 
               
               
                   
               
               
                 1463 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.9 
                 2.74 
                 510.23 
               
               
                   
               
               
                 1464 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.6 
                 3.84 
                 538.20 
               
               
                   
               
               
                 1465 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.1 
                 4.41 
                 586.21 
               
               
                   
               
               
                 1466 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.5 
                 3.65 
                 546.16 
               
               
                   
               
               
                 1467 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 49.3 
                 2.8 
                 480.20 
               
               
                   
               
               
                 1468 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.7 
                 4.11 
                 491.15 
               
               
                   
               
               
                 1469 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.7 
                 4.71 
                 557.14 
               
               
                   
               
               
                 1470 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.2 
                 3.59 
                 570.24 
               
               
                   
               
               
                 1471 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.1 
                 4.11 
                 453.19 
               
               
                   
               
               
                 1472 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 29.5 
                 5.12 
                 609.14 
               
               
                   
               
               
                 1473 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 9.9 
                 4.44 
                 479.20 
               
               
                   
               
               
                 1474 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.8 
                 5.36 
                 491.28 
               
               
                   
               
               
                 1475 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.2 
                 5.29 
                 499.26 
               
               
                   
               
               
                 1476 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.5 
                 4.37 
                 554.27 
               
               
                   
               
               
                 1477 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.6 
                 5.33 
                 570.26 
               
               
                   
               
               
                 1478 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.1 
                 5.67 
                 574.20 
               
               
                   
               
               
                 1479 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.3 
                 3.89 
                 522.29 
               
               
                   
               
               
                 1480 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.2 
                 4.94 
                 550.28 
               
               
                   
               
               
                 1481 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.5 
                 5.44 
                 598.26 
               
               
                   
               
               
                 1482 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86 
                 4.84 
                 558.24 
               
               
                   
               
               
                 1483 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 50.1 
                 3.93 
                 492.29 
               
               
                   
               
               
                 1484 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.5 
                 5.23 
                 503.25 
               
               
                   
               
               
                 1485 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.3 
                 5.68 
                 569.19 
               
               
                   
               
               
                 1486 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.3 
                 4.51 
                 582.31 
               
               
                   
               
               
                 1487 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.7 
                 5.22 
                 465.25 
               
               
                   
               
               
                 1488 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 26.1 
                 6.06 
                 621.20 
               
               
                   
               
               
                 1489 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 16.1 
                 5.51 
                 491.28 
               
               
                   
               
               
                 1490 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77 
                 5.02 
                 453.22 
               
               
                   
               
               
                 1491 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 48.4 
                 4.88 
                 461.16 
               
               
                   
               
               
                 1492 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.3 
                 3.74 
                 516.22 
               
               
                   
               
               
                 1493 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.6 
                 4.85 
                 532.2 
               
               
                   
               
               
                 1494 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.4 
                 5.23 
                 536.15 
               
               
                   
               
               
                 1495 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.9 
                 3.29 
                 484.23 
               
               
                   
               
               
                 1496 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.5 
                 4.51 
                 512.22 
               
               
                   
               
               
                 1497 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.9 
                 4.96 
                 560.17 
               
               
                   
               
               
                 1498 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.5 
                 4.29 
                 520.16 
               
               
                   
               
               
                 1499 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.7 
                 3.32 
                 454.19 
               
               
                   
               
               
                 1500 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.7 
                 4.78 
                 465.14 
               
               
                   
               
               
                 1501 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.1 
                 5.26 
                 531.13 
               
               
                   
               
               
                 1502 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.8 
                 3.95 
                 544.22 
               
               
                   
               
               
                 1503 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.5 
                 4.83 
                 427.16 
               
               
                   
               
               
                 1504 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 24 
                 5.6 
                 583.11 
               
               
                   
               
               
                 1505 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 17.7 
                 5.12 
                 453.21 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R5 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                 1506 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.7 
                 5.52 
                 596.26 
               
               
                   
               
               
                 1507 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.2 
                 5.37 
                 562.23 
               
               
                   
               
               
                 1508 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77 
                 4.62 
                 583.26 
               
               
                   
               
               
                 1509 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.1 
                 3.7 
                 579.25 
               
               
                   
               
               
                 1510 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.6 
                 5.32 
                 535.23 
               
               
                   
               
               
                 1511 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.6 
                 4 
                 570.27 
               
               
                   
               
               
                 1512 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88 
                 5.12 
                 474.19 
               
               
                   
               
               
                 1513 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.5 
                 5.09 
                 519.14 
               
               
                   
               
               
                 1514 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.2 
                 5.7 
                 505.1 
               
               
                   
               
               
                 1515 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88 
                 3.74 
                 475.17 
               
               
                   
               
               
                 1516 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.7 
                 5.58 
                 487.20 
               
               
                   
               
               
                 1517 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.3 
                 3.88 
                 532.18 
               
               
                   
               
               
                 1518 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.4 
                 3 
                 487.27 
               
               
                   
               
               
                 1519 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 4.86 
                 443.21 
               
               
                   
               
               
                 1520 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.8 
                 3.58 
                 478.28 
               
               
                   
               
               
                 1521 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.4 
                 5.2 
                 478.28 
               
               
                   
               
               
                 1522 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.8 
                 5.37 
                 488.26 
               
               
                   
               
               
                 1523 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.3 
                 5.13 
                 523.27 
               
               
                   
               
               
                 1524 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.2 
                 5.7 
                 509.2 
               
               
                   
               
               
                 1525 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91 
                 3.88 
                 479.26 
               
               
                   
               
               
                 1526 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.5 
                 5.62 
                 491.29 
               
               
                   
               
               
                 1527 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.1 
                 4.1 
                 536.28 
               
               
                   
               
               
                 1528 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.9 
                 5.68 
                 546.25 
               
               
                   
               
               
                 1529 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92 
                 5.54 
                 512.24 
               
               
                   
               
               
                 1530 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.4 
                 3.7 
                 529.3 
               
               
                   
               
               
                 1531 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.4 
                 5.49 
                 485.23 
               
               
                   
               
               
                 1532 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.4 
                 4.2 
                 520.28 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R5 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                 1533 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.1 
                 4.56 
                 452.20 
               
               
                   
               
               
                 1534 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.8 
                 4.76 
                 462.18 
               
               
                   
               
               
                 1535 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.5 
                 4.58 
                 497.22 
               
               
                   
               
               
                 1536 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.4 
                 3.21 
                 453.21 
               
               
                   
               
               
                 1537 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.2 
                 5.04 
                 465.22 
               
               
                   
               
               
                 1538 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.7 
                 3.44 
                 510.22 
               
               
                   
               
               
                 1539 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.6 
                 5.14 
                 520.18 
               
               
                   
               
               
                 1540 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.2 
                 4.93 
                 486.17 
               
               
                   
               
               
                 1541 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.4 
                 2.98 
                 503.26 
               
               
                   
               
               
                 1542 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.9 
                 4.84 
                 459.18 
               
               
                   
               
               
                 1543 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.1 
                 3.55 
                 494.26 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R5 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                 1544 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.5 
                 4.19 
                 425.25 
               
               
                   
               
               
                 1545 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.8 
                 5.1 
                 535.25 
               
               
                   
               
               
                 1546 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.7 
                 4.67 
                 484.23 
               
               
                   
               
               
                 1547 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88 
                 5.46 
                 537.27 
               
               
                   
               
               
                 1548 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.4 
                 4.72 
                 480.22 
               
               
                   
               
               
                 1549 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 4.94 
                 494.23 
               
               
                   
               
               
                 1550 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.6 
                 4.92 
                 522.18 
               
               
                   
               
               
                 1551 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.9 
                 5.03 
                 599.27 
               
               
                   
               
               
                 1552 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.3 
                 4.7 
                 486.20 
               
               
                   
               
               
                 1553 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.7 
                 3.36 
                 455.18 
               
               
                   
               
               
                 1554 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 3.68 
                 543.20 
               
               
                   
               
               
                 1555 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.7 
                 3.91 
                 557.20 
               
               
                   
               
               
                 1556 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.9 
                 5.06 
                 496.26 
               
               
                   
               
               
                 1557 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.1 
                 4.35 
                 420.21 
               
               
                   
               
               
                 1558 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.5 
                 5.2 
                 530.22 
               
               
                   
               
               
                 1559 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.7 
                 4.62 
                 495.27 
               
               
                   
               
               
                 1560 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.9 
                 4.44 
                 531.25 
               
               
                   
               
               
                 1561 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.7 
                 5.16 
                 584.30 
               
               
                   
               
               
                 1562 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.4 
                 4.51 
                 527.25 
               
               
                   
               
               
                 1563 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.1 
                 4.66 
                 541.25 
               
               
                   
               
               
                 1564 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.4 
                 4.66 
                 569.19 
               
               
                   
               
               
                 1565 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.9 
                 5.03 
                 646.34 
               
               
                   
               
               
                 1566 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.7 
                 4.44 
                 533.23 
               
               
                   
               
               
                 1567 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85 
                 3.46 
                 502.24 
               
               
                   
               
               
                 1568 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.8 
                 3.82 
                 590.27 
               
               
                   
               
               
                 1569 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.5 
                 4.03 
                 604.26 
               
               
                   
               
               
                 1570 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.9 
                 4.74 
                 543.27 
               
               
                   
               
               
                 1571 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.3 
                 4.13 
                 467.25 
               
               
                   
               
               
                 1572 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.4 
                 4.9 
                 577.2 
               
               
                   
               
               
                 1573 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.7 
                 5.15 
                 550.3 
               
               
                   
               
               
                 1574 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.7 
                 4.9 
                 586.24 
               
               
                   
               
               
                 1575 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.4 
                 5.6 
                 639.34 
               
               
                   
               
               
                 1576 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.2 
                 4.94 
                 582.25 
               
               
                   
               
               
                 1577 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 5.17 
                 596.28 
               
               
                   
               
               
                 1578 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.7 
                 5.14 
                 624.22 
               
               
                   
               
               
                 1579 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.1 
                 5.22 
                 701.35 
               
               
                   
               
               
                 1580 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.1 
                 4.92 
                 588.23 
               
               
                   
               
               
                 1581 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.7 
                 3.67 
                 557.23 
               
               
                   
               
               
                 1582 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81 
                 3.9 
                 645.32 
               
               
                   
               
               
                 1583 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.2 
                 4.12 
                 659.31 
               
               
                   
               
               
                 1584 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.4 
                 5.26 
                 598.26 
               
               
                   
               
               
                 1585 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.6 
                 4.62 
                 522.25 
               
               
                   
               
               
                 1586 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.3 
                 5.39 
                 632.29 
               
               
                   
               
               
                 1587 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.8 
                 4.94 
                 481.16 
               
               
                   
               
               
                 1588 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.3 
                 4.71 
                 517.16 
               
               
                   
               
               
                 1589 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.6 
                 5.54 
                 570.16 
               
               
                   
               
               
                 1590 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.8 
                 4.78 
                 513.13 
               
               
                   
               
               
                 1591 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.2 
                 4.99 
                 527.15 
               
               
                   
               
               
                 1592 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.9 
                 4.98 
                 555.07 
               
               
                   
               
               
                 1593 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.1 
                 5.21 
                 632.22 
               
               
                   
               
               
                 1594 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.9 
                 4.72 
                 519.10 
               
               
                   
               
               
                 1595 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.4 
                 3.47 
                 488.12 
               
               
                   
               
               
                 1596 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.5 
                 3.82 
                 576.16 
               
               
                   
               
               
                 1597 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.1 
                 4.06 
                 590.12 
               
               
                   
               
               
                 1598 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.1 
                 5.08 
                 529.16 
               
               
                   
               
               
                 1599 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.8 
                 4.34 
                 453.13 
               
               
                   
               
               
                 1600 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.9 
                 5.26 
                 563.13 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R5 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                 1601 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.1 
                 3.87 
                 409.24 
               
               
                   
               
               
                 1602 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.1 
                 4.0 
                 423.26 
               
               
                   
               
               
                 1603 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.2 
                 4.1 
                 443.21 
               
               
                   
               
               
                 1604 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91 
                 3.9 
                 427.24 
               
               
                   
               
               
                 1605 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 57.6 
                 4.4 
                 493.23 
               
               
                   
               
               
                 1606 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 48.1 
                 4.12 
                 423.27 
               
               
                   
               
               
                 1607 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 45.1 
                 4.2 
                 443.22 
               
               
                   
               
               
                 1608 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.8 
                 4.49 
                 493.24 
               
               
                   
               
               
                 1609 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54.5 
                 3.98 
                 454.26 
               
               
                   
               
               
                 1610 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84 
                 4.19 
                 443.23 
               
               
                   
               
               
                 1611 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 4.49 
                 493.25 
               
               
                   
               
               
                 1612 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.2 
                 4.51 
                 477.21 
               
               
                   
               
               
                 1613 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.1 
                 4.84 
                 545.22 
               
               
                   
               
               
                 1614 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.7 
                 4.34 
                 459.30 
               
               
                   
               
               
                 1615 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.6 
                 3.95 
                 423.29 
               
               
                   
               
               
                 1616 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.8 
                 4.6 
                 499.35 
               
               
                   
               
               
                 1617 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.9 
                 4.86  
                 519.27 
               
               
                   
               
               
                 1618 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62 
                 4.6 
                 545.3 
               
               
                   
               
               
                 1619 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.7 
                 4.28 
                 449.32 
               
               
                   
               
               
                 1620 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.1 
                 4.62 
                 483.29 
               
               
                   
               
               
                 1621 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.8 
                 4.41 
                 431.26 
               
               
                   
               
               
                 1622 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.2 
                 4.55 
                 445.26 
               
               
                   
               
               
                 1623 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 48.9 
                 4.66 
                 465.21 
               
               
                   
               
               
                 1624 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89 
                 4.46 
                 449.27 
               
               
                   
               
               
                 1625 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56.7 
                 4.94 
                 515.24 
               
               
                   
               
               
                 1626 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.4 
                 4.65 
                 445.25 
               
               
                   
               
               
                 1627 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 44.5 
                 4.72 
                 465.21 
               
               
                   
               
               
                 1628 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.7 
                 5.01 
                 515.24 
               
               
                   
               
               
                 1629 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.9 
                 4.5 
                 476.27 
               
               
                   
               
               
                 1630 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.8 
                 4.74 
                 465.21 
               
               
                   
               
               
                 1631 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.6 
                 5.02 
                 515.24 
               
               
                   
               
               
                 1632 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.6 
                 5.05 
                 499.19 
               
               
                   
               
               
                 1633 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.4 
                 5.35 
                 567.21 
               
               
                   
               
               
                 1634 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.6 
                 4.88 
                 481.28 
               
               
                   
               
               
                 1635 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.6 
                 4.49 
                 445.26 
               
               
                   
               
               
                 1636 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.1 
                 5.14 
                 521.28 
               
               
                   
               
               
                 1637 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.2 
                 5.38 
                 541.23 
               
               
                   
               
               
                 1638 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90 
                 5.1 
                 567.3 
               
               
                   
               
               
                 1639 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.9 
                 4.84 
                 471.28 
               
               
                   
               
               
                 1640 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.3 
                 5.13 
                 505.28 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R5 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                 1641 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.5 
                 3.86 
                 423.29 
               
               
                   
               
               
                 1642 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.9 
                 4 
                 437.30 
               
               
                   
               
               
                 1643 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.1 
                 4.07 
                 457.25 
               
               
                   
               
               
                 1644 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.9 
                 3.89 
                 441.27 
               
               
                   
               
               
                 1645 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.5 
                 4.35 
                 507.27 
               
               
                   
               
               
                 1646 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.6 
                 4.08 
                 437.31 
               
               
                   
               
               
                 1647 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.2 
                 4.14 
                 457.26 
               
               
                   
               
               
                 1648 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.7 
                 4.42 
                 507.27 
               
               
                   
               
               
                 1649 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.9 
                 3.96 
                 468.26 
               
               
                   
               
               
                 1650 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.6 
                 41.6 
                 457.25 
               
               
                   
               
               
                 1651 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.5 
                 4.46 
                 507.26 
               
               
                   
               
               
                 1652 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80 
                 4.46 
                 491.21 
               
               
                   
               
               
                 1653 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.7 
                 4.78 
                 559.24 
               
               
                   
               
               
                 1654 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.3 
                 4.28 
                 473.33 
               
               
                   
               
               
                 1655 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.4 
                 3.93 
                 437.30 
               
               
                   
               
               
                 1656 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.5 
                 4.55 
                 513.33 
               
               
                   
               
               
                 1657 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.8 
                 4.82 
                 533.27 
               
               
                   
               
               
                 1658 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58 
                 4.5 
                 559.3 
               
               
                   
               
               
                 1659 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.1 
                 4.24 
                 463.32 
               
               
                   
               
               
                 1660 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.2 
                 4.53 
                 497.29 
               
               
                   
               
               
                 1661 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 36.9 
                 4.42 
                 445.25 
               
               
                   
               
               
                 1662 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 31 
                 4.56 
                 459.28 
               
               
                   
               
               
                 1663 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 38.9 
                 4.67 
                 479.24 
               
               
                   
               
               
                 1664 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 43.4 
                 4.47 
                 463.27 
               
               
                   
               
               
                 1665 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 47.9 
                 4.98 
                 529.2 
               
               
                   
               
               
                 1666 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 32.1 
                 4.66 
                 459.28 
               
               
                   
               
               
                 1667 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 23 
                 4.74 
                 479.23 
               
               
                   
               
               
                 1668 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 38.1 
                 5.02 
                 529.25 
               
               
                   
               
               
                 1669 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35.5 
                 4.51 
                 490.27 
               
               
                   
               
               
                 1670 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 47.1 
                 4.74 
                 479.23 
               
               
                   
               
               
                 1671 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 37.1 
                 5.04 
                 529.25 
               
               
                   
               
               
                 1672 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.9 
                 5.07 
                 513.19 
               
               
                   
               
               
                 1673 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.8 
                 5.34 
                 581.23 
               
               
                   
               
               
                 1674 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 20.5 
                 4.91 
                 495.27 
               
               
                   
               
               
                 1675 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72 
                 4.52 
                 459.28 
               
               
                   
               
               
                 1676 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.1 
                 5.14 
                 535.30 
               
               
                   
               
               
                 1677 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.3 
                 5.4 
                 555.23 
               
               
                   
               
               
                 1678 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 52 
                 5.1 
                 581.3 
               
               
                   
               
               
                 1679 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.3 
                 4.84 
                 485.31 
               
               
                   
               
               
                 1680 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.7 
                 5.14 
                 519.29 
               
               
                   
               
               
                 1681 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.7 
                 4.26 
                 471.34 
               
               
                   
               
               
                 1682 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.3 
                 4.36 
                 485.34 
               
               
                   
               
               
                 1683 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 51.6 
                 4.47 
                 485.33 
               
               
                   
               
               
                 1684 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33.6 
                 4.39 
                 501.32 
               
               
                   
               
               
                 1685 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.9 
                 4.7 
                 539.29 
               
               
                   
               
               
                 1686 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76 
                 4.77 
                 555.28 
               
               
                   
               
               
                 1687 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 53.2 
                 4.34 
                 489.30 
               
               
                   
               
               
                 1688 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59.2 
                 4.51 
                 505.27 
               
               
                   
               
               
                 1689 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.7 
                 4.57 
                 549.21 
               
               
                   
               
               
                 1690 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 4.84 
                 547.34 
               
               
                   
               
               
                 1691 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.8 
                 4.49 
                 485.32 
               
               
                   
               
               
                 1692 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.4 
                 4.25 
                 510.37 
               
               
                   
               
               
                 1693 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.0 
                 4.83 
                 555.27 
               
               
                   
               
               
                 1694 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 44.5 
                 4.39 
                 489.30 
               
               
                   
               
               
                 1695 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 42.7 
                 4.57 
                 505.25 
               
               
                   
               
               
                 1696 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.8 
                 4.97 
                 547.32 
               
               
                   
               
               
                 1697 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.9 
                 4.56 
                 499.39 
               
               
                   
               
               
                 1698 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.8 
                 4.27 
                 531.36 
               
               
                   
               
               
                 1699 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.5 
                 4.35 
                 507.33 
               
               
                   
               
               
                 1700 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.9 
                 4.34 
                 507.33 
               
               
                   
               
               
                 1701 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.8 
                 4.27 
                 507.32 
               
               
                   
               
               
                 1702 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.9 
                 4.41 
                 507.32 
               
               
                   
               
               
                 1703 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.3 
                 4.49 
                 507.29 
               
               
                   
               
               
                 1704 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.5 
                 4.75 
                 539.22 
               
               
                   
               
               
                 1705 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.9 
                 4.7 
                 521.31 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R1 
                 R5 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                 1706 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.3 
                 3.8 
                 448.31 
               
               
                   
               
               
                 1707 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.0 
                 4.3 
                 482.24 
               
               
                   
               
               
                 1708 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.0 
                 2.4 
                 370.24 
               
               
                   
               
               
                 1709 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.6 
                 3.88 
                 387.26 
               
               
                   
               
               
                 1710 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 53.2 
                 3.0 
                 394.2 
               
               
                   
               
               
                 1711 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.2 
                 2.3 
                 449.29 
               
               
                   
               
               
                 1712 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.7 
                 4.13 
                 443.29 
               
               
                   
               
               
                 1713 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.3 
                 3.7 
                 419.28 
               
               
                   
               
               
                 1714 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.8 
                 3.5 
                 437.25 
               
               
                   
               
               
                 1715 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.0 
                 4.4 
                 469.30 
               
               
                   
               
               
                 1716 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.5 
                 4.12 
                 485.20 
               
               
                   
               
               
                 1717 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.1 
                 2.59 
                 428.29 
               
               
                   
               
               
                 1718 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.7 
                 2.8 
                 490.35 
               
               
                   
               
               
                 1719 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.0 
                 4.68 
                 529.23 
               
               
                   
               
               
                 1720 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.0 
                 3.94 
                 399.29 
               
               
                   
               
               
                 1721 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.4 
                 3.7 
                 480.32 
               
               
                   
               
               
                 1722 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.1 
                 4.14 
                 514.28 
               
               
                   
               
               
                 1723 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.1 
                 2.44 
                 402.24 
               
               
                   
               
               
                 1724 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.5 
                 3.73 
                 419.3 
               
               
                   
               
               
                 1725 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56.1 
                 3.0 
                 416.2 
               
               
                   
               
               
                 1726 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.1 
                 2.3 
                 481.33 
               
               
                   
               
               
                 1727 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.3 
                 3.96 
                 475.31 
               
               
                   
               
               
                 1728 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.2 
                 2.9 
                 448.3 
               
               
                   
               
               
                 1729 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.7 
                 3.61 
                 451.29 
               
               
                   
               
               
                 1730 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.5 
                 3.37 
                 469.28 
               
               
                   
               
               
                 1731 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.7 
                 4.22 
                 501.32 
               
               
                   
               
               
                 1732 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.7 
                 3.95 
                 517.20 
               
               
                   
               
               
                 1733 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.6 
                 2.61 
                 460.32 
               
               
                   
               
               
                 1734 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.8 
                 2.8 
                 522.35 
               
               
                   
               
               
                 1735 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.0 
                 4.48 
                 561.23 
               
               
                   
               
               
                 1736 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.2 
                 3.8 
                 431.31 
               
               
                   
               
               
                 1737 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.1 
                 4.76 
                 546.27 
               
               
                   
               
               
                 1738 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.5 
                 5.16 
                 580.24 
               
               
                   
               
               
                 1739 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.5 
                 3.72 
                 468.24 
               
               
                   
               
               
                 1740 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.1 
                 4.74 
                 485.29 
               
               
                   
               
               
                 1741 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.7 
                 3.04 
                 492.24 
               
               
                   
               
               
                 1742 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.7 
                 3.4 
                 547.28 
               
               
                   
               
               
                 1743 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.9 
                 4.96 
                 541.23 
               
               
                   
               
               
                 1744 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 55.2 
                 2.9 
                 514.27 
               
               
                   
               
               
                 1745 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.2 
                 4.7 
                 517.25 
               
               
                   
               
               
                 1746 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.7 
                 4.39 
                 535.21 
               
               
                   
               
               
                 1747 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.3 
                 5.22 
                 567.25 
               
               
                   
               
               
                 1748 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.7 
                 4.9 
                 583.16 
               
               
                   
               
               
                 1749 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.8 
                 3.53 
                 526.28 
               
               
                   
               
               
                 1750 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.3 
                 3.7 
                 588.34 
               
               
                   
               
               
                 1751 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.4 
                 5.41 
                 627.20 
               
               
                   
               
               
                 1752 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.9 
                 4.88 
                 497.31 
               
               
                   
               
               
                 1753 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.4 
                 4.53 
                 516.2 
               
               
                   
               
               
                 1754 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.2 
                 4.96 
                 550.24 
               
               
                   
               
               
                 1755 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.1 
                 3.39 
                 438.25 
               
               
                   
               
               
                 1756 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.7 
                 4.71 
                 455.28 
               
               
                   
               
               
                 1757 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56.6 
                 2.8 
                 462.24 
               
               
                   
               
               
                 1758 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.0 
                 3.0 
                 517.30 
               
               
                   
               
               
                 1759 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.6 
                 4.9 
                 511.26 
               
               
                   
               
               
                 1760 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.1 
                 2.8 
                 484.3 
               
               
                   
               
               
                 1761 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.4 
                 4.44 
                 487.27 
               
               
                   
               
               
                 1762 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 52.0 
                 4.3 
                 505.23 
               
               
                   
               
               
                 1763 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.5 
                 5.12 
                 537.28 
               
               
                   
               
               
                 1764 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.5 
                 4.93 
                 553.17 
               
               
                   
               
               
                 1765 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.2 
                 3.34 
                 496.29 
               
               
                   
               
               
                 1766 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.9 
                 3.5 
                 558.31 
               
               
                   
               
               
                 1767 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 53.4 
                 5.39 
                 597.22 
               
               
                   
               
               
                 1768 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.6 
                 4.81 
                 467.29 
               
               
                   
               
               
                 1769 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.5 
                 3.5 
                 540.32 
               
               
                   
               
               
                 1770 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.4 
                 5.01 
                 574.27 
               
               
                   
               
               
                 1771 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.9 
                 3.72 
                 462.30 
               
               
                   
               
               
                 1772 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.9 
                 4.78 
                 479.36 
               
               
                   
               
               
                 1773 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.3 
                 3.11 
                 486.32 
               
               
                   
               
               
                 1774 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.0 
                 3.4 
                 541.35 
               
               
                   
               
               
                 1775 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.3 
                 4.9 
                 535.31 
               
               
                   
               
               
                 1776 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.9 
                 3.0 
                 508.34 
               
               
                   
               
               
                 1777 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.9 
                 4.58 
                 511.33 
               
               
                   
               
               
                 1778 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.1 
                 4.4 
                 529.3 
               
               
                   
               
               
                 1779 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.1 
                 5.1 
                 561.3 
               
               
                   
               
               
                 1780 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.8 
                 4.9 
                 577.23 
               
               
                   
               
               
                 1781 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.6 
                 3.64 
                 520.34 
               
               
                   
               
               
                 1782 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.9 
                 3.7 
                 582.4 
               
               
                   
               
               
                 1783 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.0 
                 5.34 
                 621.28 
               
               
                   
               
               
                 1784 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.3 
                 4.85 
                 491.36 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R1 
                 R5 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                 1785 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.9 
                 4.44 
                 435.25 
               
               
                   
               
               
                 1786 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.8 
                 4.83 
                 437.30 
               
               
                   
               
               
                 1787 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.5 
                 3.13 
                 464.27 
               
               
                   
               
               
                 1788 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.3 
                 3.28 
                 526.38 
               
               
                   
               
               
                 1789 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.6 
                 4.67 
                 543.32 
               
               
                   
               
               
                 1790 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.8 
                 2.9 
                 458.32 
               
               
                   
               
               
                 1791 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.7 
                 3.99 
                 508.34 
               
               
                   
               
               
                 1792 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.9 
                 5.41 
                 526.38 
               
               
                   
               
               
                 1793 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.4 
                 4.85 
                 511.27 
               
               
                   
               
               
                 1794 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.2 
                 5.07 
                 533.35 
               
               
                   
               
               
                 1795 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.1 
                 3.55 
                 536.28 
               
               
                   
               
               
                 1796 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.3 
                 4.66 
                 471.3 
               
               
                   
               
               
                 1797 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.3 
                 4.41 
                 461.31 
               
               
                   
               
               
                 1798 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.1 
                 4.95 
                 505.33 
               
               
                   
               
               
                 1799 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.0 
                 3.5 
                 532.3 
               
               
                   
               
               
                 1800 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.1 
                 4.87 
                 483.34 
               
               
                   
               
               
                 1801 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.62 
                 3.96 
                 387.33 
               
               
                   
               
               
                 1802 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.4 
                 4.39 
                 389.33 
               
               
                   
               
               
                 1803 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.2 
                 2.57 
                 416.32 
               
               
                   
               
               
                 1804 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.2 
                 2.9 
                 478.3 
               
               
                   
               
               
                 1805 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.2 
                 4.26 
                 495.34 
               
               
                   
               
               
                 1806 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.2 
                 2.5 
                 410.3 
               
               
                   
               
               
                 1807 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.3 
                 3.6 
                 460.37 
               
               
                   
               
               
                 1808 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.0 
                 5.01 
                 478.39 
               
               
                   
               
               
                 1809 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.3 
                 4.45 
                 463.31 
               
               
                   
               
               
                 1810 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.9 
                 4.73 
                 485.37 
               
               
                   
               
               
                 1811 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.5 
                 3.14 
                 488.31 
               
               
                   
               
               
                 1812 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.1 
                 4.28 
                 423.35 
               
               
                   
               
               
                 1813 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.2 
                 3.99 
                 413.29 
               
               
                   
               
               
                 1814 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.5 
                 4.55 
                 457.33 
               
               
                   
               
               
                 1815 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.7 
                 3.1 
                 484.3 
               
               
                   
               
               
                 1816 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.7 
                 4.44 
                 435.33 
               
               
                   
               
               
                 1817 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.7 
                 5.02 
                 471.33 
               
               
                   
               
               
                 1818 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.2 
                 5.31 
                 473.37 
               
               
                   
               
               
                 1819 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.6 
                 3.59 
                 500.35 
               
               
                   
               
               
                 1820 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.8 
                 3.7 
                 562.4 
               
               
                   
               
               
                 1821 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.5 
                 5.04 
                 579.32 
               
               
                   
               
               
                 1822 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 39.8 
                 3.3 
                 494.3 
               
               
                   
               
               
                 1823 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.8 
                 4.55 
                 544.33 
               
               
                   
               
               
                 1824 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.4 
                 5.78 
                 562.36 
               
               
                   
               
               
                 1825 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.3 
                 5.27 
                 547.25 
               
               
                   
               
               
                 1826 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.7 
                 5.58 
                 569.32 
               
               
                   
               
               
                 1827 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.3 
                 4.17 
                 572.27 
               
               
                   
               
               
                 1828 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.4 
                 5.17 
                 507.34 
               
               
                   
               
               
                 1829 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.3 
                 4.91 
                 497.28 
               
               
                   
               
               
                 1830 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.4 
                 5.41 
                 541.29 
               
               
                   
               
               
                 1831 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.4 
                 3.8 
                 568.3 
               
               
                   
               
               
                 1832 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.9 
                 5.31 
                 519.33 
               
               
                   
               
               
                 1833 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.3 
                 4.99 
                 455.27 
               
               
                   
               
               
                 1834 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.5 
                 5.3 
                 457.30 
               
               
                   
               
               
                 1835 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.3 
                 3.42 
                 484.27 
               
               
                   
               
               
                 1836 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.6 
                 3.65 
                 546.29 
               
               
                   
               
               
                 1837 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.8 
                 4.91 
                 563.24 
               
               
                   
               
               
                 1838 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.2 
                 3.3 
                 478.24 
               
               
                   
               
               
                 1839 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.6 
                 4.5 
                 528.30 
               
               
                   
               
               
                 1840 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.4 
                 5.68 
                 546.30 
               
               
                   
               
               
                 1841 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.8 
                 5.31 
                 521.23 
               
               
                   
               
               
                 1842 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.2 
                 5.57 
                 553.28 
               
               
                   
               
               
                 1843 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.4 
                 4.11 
                 556.21 
               
               
                   
               
               
                 1844 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.9 
                 5.15 
                 491.29 
               
               
                   
               
               
                 1845 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.4 
                 4.93 
                 481.27 
               
               
                   
               
               
                 1846 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.3 
                 5.29 
                 525.25 
               
               
                   
               
               
                 1847 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.6 
                 3.7 
                 552.3 
               
               
                   
               
               
                 1848 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.1 
                 5.3 
                 503.29 
               
               
                   
               
               
                 1849 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.9 
                 4.25 
                 451.32 
               
               
                   
               
               
                 1850 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.1 
                 4.64 
                 453.35 
               
               
                   
               
               
                 1851 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.6 
                 2.72 
                 480.33 
               
               
                   
               
               
                 1852 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.9 
                 3.16 
                 542.35 
               
               
                   
               
               
                 1853 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.7 
                 4.28 
                 559.29 
               
               
                   
               
               
                 1854 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.3 
                 2.82 
                 474.33 
               
               
                   
               
               
                 1855 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.4 
                 3.83 
                 524.32 
               
               
                   
               
               
                 1856 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.0 
                 5.0 
                 542.36 
               
               
                   
               
               
                 1857 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.6 
                 4.73 
                 527.28 
               
               
                   
               
               
                 1858 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.8 
                 5.01 
                 549.31 
               
               
                   
               
               
                 1859 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.4 
                 3.49 
                 552.26 
               
               
                   
               
               
                 1860 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.4 
                 4.54 
                 487.35 
               
               
                   
               
               
                 1861 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.3 
                 4.28 
                 477.30 
               
               
                   
               
               
                 1862 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.9 
                 4.59 
                 521.29 
               
               
                   
               
               
                 1863 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.5 
                 3.2 
                 548.3 
               
               
                   
               
               
                 1864 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.5 
                 4.65 
                 499.32 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R1 
                 R5 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                 1865 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.7 
                 4.94 
                 435.29 
               
               
                   
               
               
                 1866 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.0 
                 4.66 
                 443.26 
               
               
                   
               
               
                 1867 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 26.2 
                 4.82 
                 494.26 
               
               
                   
               
               
                 1868 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.4 
                 4.8 
                 502.28 
               
               
                   
               
               
                 1869 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.6 
                 5.48 
                 519.28 
               
               
                   
               
               
                 1870 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.17 
                 5.3 
                 451.33 
               
               
                   
               
               
                 1871 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.1 
                 3.4 
                 542.3 
               
               
                   
               
               
                 1872 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35.7 
                 4.48 
                 435.20 
               
               
                   
               
               
                 1873 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.8 
                 3.8 
                 502.26 
               
               
                   
               
               
                 1874 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.1 
                 5.41 
                 533.29 
               
               
                   
               
               
                 1875 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.5 
                 5.14 
                 513.22 
               
               
                   
               
               
                 1876 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 47.8 
                 4.82 
                 455.24 
               
               
                   
               
               
                 1877 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.1 
                 5.32 
                 521.24 
               
               
                   
               
               
                 1878 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.8 
                 5.31 
                 505.26 
               
               
                   
               
               
                 1879 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 19.7 
                 4.37 
                 395.24 
               
               
                   
               
               
                 1880 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.4 
                 5.14 
                 511.22 
               
               
                   
               
               
                 1881 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.7 
                 4.95 
                 463.31 
               
               
                   
               
               
                 1882 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.2 
                 4.71 
                 471.27 
               
               
                   
               
               
                 1883 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.2 
                 4.84 
                 522.26 
               
               
                   
               
               
                 1884 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.7 
                 4.9 
                 530.28 
               
               
                   
               
               
                 1885 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.4 
                 5.54 
                 547.28 
               
               
                   
               
               
                 1886 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.8 
                 5.3 
                 479.34 
               
               
                   
               
               
                 1887 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.9 
                 3.6 
                 570.24 
               
               
                   
               
               
                 1888 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 30.2 
                 4.53 
                 463.23 
               
               
                   
               
               
                 1889 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.9 
                 3.98 
                 530.26 
               
               
                   
               
               
                 1890 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.2 
                 5.42 
                 561.30 
               
               
                   
               
               
                 1891 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.8 
                 5.17 
                 541.22 
               
               
                   
               
               
                 1892 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.8 
                 4.86 
                 483.28 
               
               
                   
               
               
                 1893 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.7 
                 5.33 
                 549.26 
               
               
                   
               
               
                 1894 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.6 
                 5.34 
                 533.29 
               
               
                   
               
               
                 1895 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54.1 
                 4.43 
                 423.28 
               
               
                   
               
               
                 1896 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 47.7 
                 5.16 
                 539.26 
               
               
                   
               
               
                 1897 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.6 
                 4.44 
                 509.30 
               
               
                   
               
               
                 1898 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.6 
                 4.2 
                 517.27 
               
               
                   
               
               
                 1899 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 38.8 
                 4.53 
                 568.26 
               
               
                   
               
               
                 1900 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.1 
                 4.5 
                 576.3 
               
               
                   
               
               
                 1901 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.3 
                 5.17 
                 593.30 
               
               
                   
               
               
                 1902 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.0 
                 4.88 
                 525.34 
               
               
                   
               
               
                 1903 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.5 
                 3.3 
                 616.3 
               
               
                   
               
               
                 1904 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 34.6 
                 4.03 
                 509.21 
               
               
                   
               
               
                 1905 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.3 
                 3.6 
                 576.2 
               
               
                   
               
               
                 1906 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.1 
                 5.04 
                 607.31 
               
               
                   
               
               
                 1907 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.6 
                 4.76 
                 587.24 
               
               
                   
               
               
                 1908 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.8 
                 4.38 
                 529.28 
               
               
                   
               
               
                 1909 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.0 
                 4.95 
                 595.28 
               
               
                   
               
               
                 1910 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.1 
                 4.88 
                 579.29 
               
               
                   
               
               
                 1911 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 32.4 
                 3.89 
                 469.29 
               
               
                   
               
               
                 1912 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 49.3 
                 4.7 
                 585.26 
               
               
                   
               
               
                 1913 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.0 
                 5.59 
                 503.20 
               
               
                   
               
               
                 1914 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.5 
                 5.3 
                 511.15 
               
               
                   
               
               
                 1915 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.5 
                 5.28 
                 562.16 
               
               
                   
               
               
                 1916 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.4 
                 5.3 
                 570.1 
               
               
                   
               
               
                 1917 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.1 
                 5.98 
                 587.17 
               
               
                   
               
               
                 1918 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.4 
                 5.84 
                 519.23 
               
               
                   
               
               
                 1919 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.5 
                 3.9 
                 610.1 
               
               
                   
               
               
                 1920 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 27.2 
                 5.12 
                 503.11 
               
               
                   
               
               
                 1921 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.6 
                 4.41 
                 570.13 
               
               
                   
               
               
                 1922 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.4 
                 5.91 
                 601.19 
               
               
                   
               
               
                 1923 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.9 
                 5.66 
                 581.11 
               
               
                   
               
               
                 1924 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.4 
                 5.44 
                 523.13 
               
               
                   
               
               
                 1925 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.9 
                 5.81 
                 589.16 
               
               
                   
               
               
                 1926 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.7 
                 5.85 
                 573.15 
               
               
                   
               
               
                 1927 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 36.8 
                 5.1 
                 463.16 
               
               
                   
               
               
                 1928 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.4 
                 5.68 
                 579.13 
               
               
                   
               
               
                 1929 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.4 
                 4.65 
                 415.30 
               
               
                   
               
               
                 1930 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.5 
                 4.41 
                 423.29 
               
               
                   
               
               
                 1931 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 44.0 
                 4.62 
                 474.29 
               
               
                   
               
               
                 1932 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.1 
                 4.65 
                 482.3 
               
               
                   
               
               
                 1933 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.5 
                 5.33 
                 499.31 
               
               
                   
               
               
                 1934 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.6 
                 5.06 
                 431.33 
               
               
                   
               
               
                 1935 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.6 
                 3.4 
                 522.30 
               
               
                   
               
               
                 1936 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54.6 
                 4.2 
                 415.21 
               
               
                   
               
               
                 1937 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.4 
                 3.7 
                 482.29 
               
               
                   
               
               
                 1938 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.5 
                 5.21 
                 513.32 
               
               
                   
               
               
                 1939 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.7 
                 4.92 
                 493.24 
               
               
                   
               
               
                 1940 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.0 
                 4.58 
                 435.29 
               
               
                   
               
               
                 1941 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.1 
                 5.1 
                 501.31 
               
               
                   
               
               
                 1942 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.2 
                 5.1 
                 485.31 
               
               
                   
               
               
                 1943 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.1 
                 4.08 
                 375.28 
               
               
                   
               
               
                 1944 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.1 
                 4.9 
                 491.28 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R1 
                 R5 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                 1945 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.3 
                 4.24 
                 512.26 
               
               
                   
               
               
                 1946 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.4 
                 3.63 
                 514.25 
               
               
                   
               
               
                 1947 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.8 
                 3.1 
                 526.27 
               
               
                   
               
               
                 1948 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.7 
                 4.32 
                 530.23 
               
               
                   
               
               
                 1949 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.5 
                 4.24 
                 557.23 
               
               
                   
               
               
                 1950 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.8 
                 2.9 
                 513.26 
               
               
                   
               
               
                 1951 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.5 
                 4.92 
                 540.28 
               
               
                   
               
               
                 1952 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.7 
                 4.49 
                 526.27 
               
               
                   
               
               
                 1953 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.5 
                 3.66 
                 567.26 
               
               
                   
               
               
                 1954 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89 
                 4.08 
                 542.26 
               
               
                   
               
               
                 1955 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.7 
                 4.38 
                 530.24 
               
               
                   
               
               
                 1956 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.4 
                 2.7 
                 513.28 
               
               
                   
               
               
                 1957 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.7 
                 4.31 
                 557.23 
               
               
                   
               
               
                 1958 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.0 
                 4.44 
                 556.27 
               
               
                   
               
               
                 1959 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.7 
                 3.44 
                 514.25 
               
               
                   
               
               
                 1960 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.6 
                 4.67 
                 535.24 
               
               
                   
               
               
                 1961 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.3 
                 4.32 
                 526.27 
               
               
                   
               
               
                 1962 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.0 
                 3.75 
                 528.25 
               
               
                   
               
               
                 1963 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.7 
                 3.28 
                 540.28 
               
               
                   
               
               
                 1964 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.8 
                 4.37 
                 544.25 
               
               
                   
               
               
                 1965 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.4 
                 4.29 
                 571.24 
               
               
                   
               
               
                 1966 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.9 
                 3.1 
                 527.25 
               
               
                   
               
               
                 1967 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.1 
                 4.94 
                 554.29 
               
               
                   
               
               
                 1968 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.6 
                 4.54 
                 540.27 
               
               
                   
               
               
                 1969 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.4 
                 3.76 
                 581.27 
               
               
                   
               
               
                 1970 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.3 
                 4.16 
                 556.28 
               
               
                   
               
               
                 1971 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.0 
                 4.43 
                 544.25 
               
               
                   
               
               
                 1972 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.2 
                 2.8 
                 527.3 
               
               
                   
               
               
                 1973 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.8 
                 4.38 
                 571.24 
               
               
                   
               
               
                 1974 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.8 
                 4.5 
                 570.28 
               
               
                   
               
               
                 1975 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.9 
                 3.55 
                 528.26 
               
               
                   
               
               
                 1976 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.7 
                 4.71 
                 549.27 
               
               
                   
               
               
                 1977 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.7 
                 4.41 
                 526.29 
               
               
                   
               
               
                 1978 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.2 
                 3.82 
                 528.27 
               
               
                   
               
               
                 1979 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.4 
                 3.28 
                 540.28 
               
               
                   
               
               
                 1980 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.6 
                 4.47 
                 544.24 
               
               
                   
               
               
                 1981 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.4 
                 4.38 
                 571.24 
               
               
                   
               
               
                 1982 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.9 
                 3.1 
                 527.27 
               
               
                   
               
               
                 1983 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.3 
                 5.06 
                 554.28 
               
               
                   
               
               
                 1984 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.3 
                 4.66 
                 540.28 
               
               
                   
               
               
                 1985 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.8 
                 3.8 
                 581.28 
               
               
                   
               
               
                 1986 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.1 
                 4.25 
                 556.28 
               
               
                   
               
               
                 1987 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.4 
                 4.54 
                 544.25 
               
               
                   
               
               
                 1988 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.9 
                 2.86 
                 527.28 
               
               
                   
               
               
                 1989 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.5 
                 4.46 
                 571.24 
               
               
                   
               
               
                 1990 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.4 
                 4.6 
                 570.29 
               
               
                   
               
               
                 1991 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.8 
                 3.62 
                 528.27 
               
               
                   
               
               
                 1992 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.2 
                 4.82 
                 549.26 
               
               
                   
               
               
                 1993 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.8 
                 4.15 
                 572.25 
               
               
                   
               
               
                 1994 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.0 
                 3.58 
                 574.25 
               
               
                   
               
               
                 1995 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.5 
                 3.08 
                 586.3 
               
               
                   
               
               
                 1996 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.3 
                 4.2 
                 590.27 
               
               
                   
               
               
                 1997 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.3 
                 4.12 
                 617.26 
               
               
                   
               
               
                 1998 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.1 
                 2.91 
                 573.28 
               
               
                   
               
               
                 1999 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.5 
                 4.74 
                 600.31 
               
               
                   
               
               
                 2000 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.3 
                 4.37 
                 586.28 
               
               
                   
               
               
                 2001 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.4 
                 3.6 
                 627.28 
               
               
                   
               
               
                 2002 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.4 
                 3.98 
                 602.28 
               
               
                   
               
               
                 2003 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.1 
                 4.26 
                 590.27 
               
               
                   
               
               
                 2004 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.5 
                 2.7 
                 573.26 
               
               
                   
               
               
                 2005 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.9 
                 4.2 
                 617.27 
               
               
                   
               
               
                 2006 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.9 
                 4.32 
                 616.31 
               
               
                   
               
               
                 2007 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.2 
                 3.4 
                 574.24 
               
               
                   
               
               
                 2008 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.0 
                 4.54 
                 595.29 
               
               
                   
               
               
                 2009 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.1 
                 4.72 
                 574.25 
               
               
                   
               
               
                 2010 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.1 
                 4.15 
                 576.27 
               
               
                   
               
               
                 2011 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.9 
                 3.53 
                 588.27 
               
               
                   
               
               
                 2012 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.8 
                 4.78 
                 592.26 
               
               
                   
               
               
                 2013 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.0 
                 4.68 
                 619.26 
               
               
                   
               
               
                 2014 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.6 
                 3.35 
                 575.25 
               
               
                   
               
               
                 2015 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.9 
                 5.41 
                 602.30 
               
               
                   
               
               
                 2016 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.9 
                 4.96 
                 588.26 
               
               
                   
               
               
                 2017 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.6 
                 4.09 
                 629.29 
               
               
                   
               
               
                 2018 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.7 
                 4.53 
                 604.27 
               
               
                   
               
               
                 2019 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.4 
                 4.84 
                 592.26 
               
               
                   
               
               
                 2020 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.7 
                 3.06 
                 575.31 
               
               
                   
               
               
                 2021 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.9 
                 4.74 
                 619.25 
               
               
                   
               
               
                 2022 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.6 
                 4.89 
                 618.29 
               
               
                   
               
               
                 2023 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.5 
                 3.9 
                 576.27 
               
               
                   
               
               
                 2024 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.2 
                 5.15 
                 597.27 
               
               
                   
               
               
                 2025 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.8 
                 4.94 
                 574.23 
               
               
                   
               
               
                 2026 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.4 
                 4.96 
                 592.25 
               
               
                   
               
               
                 2027 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.7 
                 4.86 
                 619.24 
               
               
                   
               
               
                 2028 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.7 
                 3.61 
                 575.2 
               
               
                   
               
               
                 2029 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.4 
                 5.13 
                 571.25 
               
               
                   
               
               
                 2030 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.0 
                 5.58 
                 602.28 
               
               
                   
               
               
                 2031 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.8 
                 5.15 
                 588.26 
               
               
                   
               
               
                 2032 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.5 
                 4.24 
                 629.28 
               
               
                   
               
               
                 2033 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.8 
                 4.7 
                 604.27 
               
               
                   
               
               
                 2034 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.3 
                 5.04 
                 592.25 
               
               
                   
               
               
                 2035 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.5 
                 4.96 
                 619.24 
               
               
                   
               
               
                 2036 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.5 
                 5.41 
                 642.26 
               
               
                   
               
               
                 2037 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.9 
                 5.12 
                 610.24 
               
               
                   
               
               
                 2038 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.4 
                 5.07 
                 618.27 
               
               
                   
               
               
                 2039 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.7 
                 5.42 
                 687.24 
               
               
                   
               
               
                 2040 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.7 
                 3.68 
                 580.30 
               
               
                   
               
               
                 2041 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.2 
                 4.89 
                 574.23 
               
               
                   
               
               
                 2042 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.4 
                 4.9 
                 592.25 
               
               
                   
               
               
                 2043 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.7 
                 4.78 
                 619.23 
               
               
                   
               
               
                 2044 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.0 
                 3.58 
                 575.25 
               
               
                   
               
               
                 2045 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.5 
                 5.16 
                 571.22 
               
               
                   
               
               
                 2046 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.2 
                 5.57 
                 602.28 
               
               
                   
               
               
                 2047 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.4 
                 5.1 
                 588.25 
               
               
                   
               
               
                 2048 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.2 
                 4.25 
                 629.27 
               
               
                   
               
               
                 2049 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.5 
                 4.64 
                 604.26 
               
               
                   
               
               
                 2050 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.6 
                 4.99 
                 592.2 
               
               
                   
               
               
                 2051 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.7 
                 4.93 
                 619.24 
               
               
                   
               
               
                 2052 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.2 
                 5.34 
                 642.25 
               
               
                   
               
               
                 2053 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.1 
                 5.06 
                 610.23 
               
               
                   
               
               
                 2054 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.6 
                 5.06 
                 618.27 
               
               
                   
               
               
                 2055 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.4 
                 5.37 
                 687.23 
               
               
                   
               
               
                 2056 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.8 
                 3.68 
                 580.30 
               
               
                   
               
               
                 2057 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.0 
                 4.37 
                 528.26 
               
               
                   
               
               
                 2058 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.3 
                 4.41 
                 546.22 
               
               
                   
               
               
                 2059 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.1 
                 4.32 
                 573.19 
               
               
                   
               
               
                 2060 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.1 
                 3 
                 529.25 
               
               
                   
               
               
                 2061 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.2 
                 4.56 
                 525.25 
               
               
                   
               
               
                 2062 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.2 
                 4.98 
                 556.26 
               
               
                   
               
               
                 2063 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.8 
                 4.56 
                 542.26 
               
               
                   
               
               
                 2064 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.6 
                 3.73 
                 583.23 
               
               
                   
               
               
                 2065 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.7 
                 4.16 
                 558.23 
               
               
                   
               
               
                 2066 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.4 
                 4.46 
                 546.22 
               
               
                   
               
               
                 2067 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.4 
                 4.4 
                 573.20 
               
               
                   
               
               
                 2068 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.7 
                 4.88 
                 596.21 
               
               
                   
               
               
                 2069 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.9 
                 4.56 
                 564.21 
               
               
                   
               
               
                 2070 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.5 
                 4.51 
                 572.26 
               
               
                   
               
               
                 2071 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.8 
                 4.91 
                 641.20 
               
               
                   
               
               
                 2072 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.2 
                 3.08 
                 534.27 
               
               
                   
               
               
                 2073 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.7 
                 4.78 
                 562.25 
               
               
                   
               
               
                 2074 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.1 
                 4.8 
                 580.23 
               
               
                   
               
               
                 2075 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.6 
                 4.68 
                 607.23 
               
               
                   
               
               
                 2076 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.5 
                 3.4 
                 563.21 
               
               
                   
               
               
                 2077 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.5 
                 4.92 
                 559.23 
               
               
                   
               
               
                 2078 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.0 
                 5.39 
                 590.27 
               
               
                   
               
               
                 2079 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.5 
                 4.98 
                 576.26 
               
               
                   
               
               
                 2080 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 42.5 
                 4.1 
                 617.23 
               
               
                   
               
               
                 2081 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.9 
                 4.58 
                 592.26 
               
               
                   
               
               
                 2082 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.5 
                 4.88 
                 580.23 
               
               
                   
               
               
                 2083 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.4 
                 4.77 
                 607.23 
               
               
                   
               
               
                 2084 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.3 
                 5.24 
                 630.26 
               
               
                   
               
               
                 2085 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.5 
                 4.97 
                 598.20 
               
               
                   
               
               
                 2086 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.6 
                 4.93 
                 606.28 
               
               
                   
               
               
                 2087 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.7 
                 5.25 
                 675.23 
               
               
                   
               
               
                 2088 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.4 
                 3.4 
                 568.26 
               
               
                   
               
               
                 2089 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.0 
                 4.64 
                 562.24 
               
               
                   
               
               
                 2090 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.0 
                 4.66 
                 580.23 
               
               
                   
               
               
                 2091 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.6 
                 4.54 
                 607.22 
               
               
                   
               
               
                 2092 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.5 
                 3.3 
                 563.25 
               
               
                   
               
               
                 2093 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.2 
                 4.8 
                 559.22 
               
               
                   
               
               
                 2094 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.2 
                 5.21 
                 590.29 
               
               
                   
               
               
                 2095 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.2 
                 4.82 
                 576.28 
               
               
                   
               
               
                 2096 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.8 
                 3.99 
                 617.26 
               
               
                   
               
               
                 2097 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.0 
                 4.44 
                 592.2 
               
               
                   
               
               
                 2098 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.8 
                 4.72 
                 580.25 
               
               
                   
               
               
                 2099 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.0 
                 4.62 
                 607.23 
               
               
                   
               
               
                 2100 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.4 
                 5.09 
                 630.26 
               
               
                   
               
               
                 2101 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.8 
                 4.8 
                 598.21 
               
               
                   
               
               
                 2102 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.7 
                 4.78 
                 606.29 
               
               
                   
               
               
                 2103 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.6 
                 5.1 
                 675.24 
               
               
                   
               
               
                 2104 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 5.6 
                 3.05 
                 568.28 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R5 
                 R2 
                 R1 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2105 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.5 
                 4.9 
                 468.27 
               
               
                   
               
               
                 2106 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.4 
                 5.01 
                 465.28 
               
               
                   
               
               
                 2107 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.3 
                 5.34 
                 505.31 
               
               
                   
               
               
                 2108 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.5 
                 4.7 
                 447.29 
               
               
                   
               
               
                 2109 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.5 
                 5.28 
                 499.26 
               
               
                   
               
               
                 2110 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.9 
                 5.38 
                 491.30 
               
               
                   
               
               
                 2111 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.0 
                 4.5 
                 489.31 
               
               
                   
               
               
                 2112 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.0 
                 5.5 
                 521.29 
               
               
                   
               
               
                 2113 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.0 
                 4.23 
                 381.29 
               
               
                   
               
               
                 2114 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.1 
                 5.02 
                 443.30 
               
               
                   
               
               
                 2115 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56.9 
                 4.2 
                 434.32 
               
               
                   
               
               
                 2116 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.8 
                 4.29 
                 431.31 
               
               
                   
               
               
                 2117 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.1 
                 4.45 
                 471.35 
               
               
                   
               
               
                 2118 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.2 
                 3.56 
                 413.29 
               
               
                   
               
               
                 2119 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.4 
                 4.68 
                 465.27 
               
               
                   
               
               
                 2120 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.3 
                 4.66 
                 457.33 
               
               
                   
               
               
                 2121 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.1 
                 3.41 
                 455.33 
               
               
                   
               
               
                 2122 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.2 
                 4.38 
                 487.36 
               
               
                   
               
               
                 2123 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.8 
                 2.99 
                 347.34 
               
               
                   
               
               
                 2124 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.2 
                 4.13 
                 409.33 
               
               
                   
               
               
                 2125 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56.9 
                 4.01 
                 513.30 
               
               
                   
               
               
                 2126 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.1 
                 3.88 
                 510.29 
               
               
                   
               
               
                 2127 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.8 
                 4.16 
                 550.29 
               
               
                   
               
               
                 2128 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.7 
                 3.49 
                 492.28 
               
               
                   
               
               
                 2129 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71 
                 4.27 
                 536.28 
               
               
                   
               
               
                 2130 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.4 
                 3.38 
                 534.30 
               
               
                   
               
               
                 2131 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.7 
                 4.29 
                 566.30 
               
               
                   
               
               
                 2132 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54.5 
                 2.98 
                 426.29 
               
               
                   
               
               
                 2133 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.1 
                 3.85 
                 488.31 
               
               
                   
               
               
                 2134 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 57.1 
                 4.5 
                 462.36 
               
               
                   
               
               
                 2135 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.2 
                 4.61 
                 459.35 
               
               
                   
               
               
                 2136 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.6 
                 4.72 
                 499.40 
               
               
                   
               
               
                 2137 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.7 
                 3.94 
                 441.32 
               
               
                   
               
               
                 2138 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.9 
                 4.99 
                 493.32 
               
               
                   
               
               
                 2139 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.5 
                 4.95 
                 485.37 
               
               
                   
               
               
                 2140 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.4 
                 3.79 
                 483.36 
               
               
                   
               
               
                 2141 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.1 
                 4.62 
                 515.38 
               
               
                   
               
               
                 2142 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.1 
                 3.49 
                 375.33 
               
               
                   
               
               
                 2143 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.1 
                 4.46 
                 437.35 
               
               
                   
               
               
                 2144 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.8 
                 5.14 
                 516.28 
               
               
                   
               
               
                 2145 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.0 
                 5.27 
                 513.28 
               
               
                   
               
               
                 2146 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.4 
                 5.58 
                 553.30 
               
               
                   
               
               
                 2147 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.6 
                 5.02 
                 495.27 
               
               
                   
               
               
                 2148 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.4 
                 5.51 
                 547.21 
               
               
                   
               
               
                 2149 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.5 
                 5.62 
                 539.29 
               
               
                   
               
               
                 2150 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.9 
                 4.86 
                 537.28 
               
               
                   
               
               
                 2151 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.2 
                 5.76 
                 569.28 
               
               
                   
               
               
                 2152 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.5 
                 4.62 
                 429.28 
               
               
                   
               
               
                 2153 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.8 
                 5.31 
                 491.31 
               
               
                   
               
               
                 2154 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.4 
                 4.47 
                 462.33 
               
               
                   
               
               
                 2155 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.6 
                 4.62 
                 479.31 
               
               
                   
               
               
                 2156 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.1 
                 4.72 
                 519.34 
               
               
                   
               
               
                 2157 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.6 
                 3.96 
                 461.31 
               
               
                   
               
               
                 2158 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.7 
                 5.0 
                 513.27 
               
               
                   
               
               
                 2159 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.3 
                 4.99 
                 505.34 
               
               
                   
               
               
                 2160 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.6 
                 3.72 
                 503.34 
               
               
                   
               
               
                 2161 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.6 
                 4.7 
                 535.32 
               
               
                   
               
               
                 2162 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.5 
                 3.38 
                 395.32 
               
               
                   
               
               
                 2163 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.1 
                 4.5 
                 457.32 
               
               
                   
               
               
                 2164 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.8 
                 4.24 
                 561.29 
               
               
                   
               
               
                 2165 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.9 
                 4.16 
                 558.27 
               
               
                   
               
               
                 2166 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.5 
                 4.42 
                 598.29 
               
               
                   
               
               
                 2167 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.8 
                 3.87 
                 540.27 
               
               
                   
               
               
                 2168 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 1.54 
                 4.52 
                 592.25 
               
               
                   
               
               
                 2169 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56.0 
                 4.54 
                 584.25 
               
               
                   
               
               
                 2170 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.5 
                 3.76 
                 582.30 
               
               
                   
               
               
                 2171 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.8 
                 4.58 
                 614.31 
               
               
                   
               
               
                 2172 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.9 
                 3.43 
                 474.30 
               
               
                   
               
               
                 2173 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.9 
                 4.16 
                 536.28 
               
               
                   
               
               
                 2174 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.9 
                 4.76 
                 510.36 
               
               
                   
               
               
                 2175 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.1 
                 4.93 
                 507.35 
               
               
                   
               
               
                 2176 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.0 
                 4.99 
                 547.36 
               
               
                   
               
               
                 2177 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.3 
                 4.27 
                 489.35 
               
               
                   
               
               
                 2178 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.3 
                 5.41 
                 541.29 
               
               
                   
               
               
                 2179 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.7 
                 5.36 
                 533.36 
               
               
                   
               
               
                 2180 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.5 
                 4.13 
                 531.35 
               
               
                   
               
               
                 2181 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.0 
                 4.99 
                 563.34 
               
               
                   
               
               
                 2182 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76 
                 3.89 
                 423.35 
               
               
                   
               
               
                 2183 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.8 
                 4.89 
                 485.38 
               
               
                   
               
               
                 2184 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.8 
                 4.43 
                 501.32 
               
               
                   
               
               
                 2185 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.2 
                 4.18 
                 545.31 
               
               
                   
               
               
                 2186 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.6 
                 5.18 
                 569.27 
               
               
                   
               
               
                 2187 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 57.2 
                 4.78 
                 589.30 
               
               
                   
               
               
                 2188 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.7 
                 4.41 
                 529.36 
               
               
                   
               
               
                 2189 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.4 
                 4.52 
                 549.28 
               
               
                   
               
               
                 2190 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.8 
                 4.24 
                 521.29 
               
               
                   
               
               
                 2191 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.4 
                 4.19 
                 481.37 
               
               
                   
               
               
                 2192 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.9 
                 4.8 
                 577.32 
               
               
                   
               
               
                 2193 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.5 
                 4.54 
                 583.24 
               
               
                   
               
               
                 2194 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.2 
                 4.76 
                 473.22 
               
               
                   
               
               
                 2195 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.6 
                 4.69 
                 517.20 
               
               
                   
               
               
                 2196 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71 
                 5.2 
                 541.18 
               
               
                   
               
               
                 2197 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69 
                 4.73 
                 561.15 
               
               
                   
               
               
                 2198 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.8 
                 5.04 
                 501.24 
               
               
                   
               
               
                 2199 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.5 
                 5.18 
                 521.16 
               
               
                   
               
               
                 2200 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.3 
                 4.8 
                 493.18 
               
               
                   
               
               
                 2201 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.9 
                 4.79 
                 453.24 
               
               
                   
               
               
                 2202 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.9 
                 5.41 
                 549.20 
               
               
                   
               
               
                 2203 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68 
                 5.2 
                 555.11 
               
               
                   
               
               
                 2204 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66 
                 5.02 
                 463.27 
               
               
                   
               
               
                 2205 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.2 
                 4.83 
                 507.28 
               
               
                   
               
               
                 2206 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.2 
                 5.48 
                 531.24 
               
               
                   
               
               
                 2207 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.3 
                 4.99 
                 551.22 
               
               
                   
               
               
                 2208 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.9 
                 5.22 
                 491.31 
               
               
                   
               
               
                 2209 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.2 
                 5.31 
                 511.24 
               
               
                   
               
               
                 2210 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.8 
                 4.98 
                 483.24 
               
               
                   
               
               
                 2211 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.4 
                 4.98 
                 443.31 
               
               
                   
               
               
                 2212 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.6 
                 5.55 
                 539.29 
               
               
                   
               
               
                 2213 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.5 
                 5.41 
                 545.19 
               
               
                   
               
               
                 2214 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 41.2 
                 4.09 
                 455.28 
               
               
                   
               
               
                 2215 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.5 
                 3.73 
                 499.35 
               
               
                   
               
               
                 2216 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.8 
                 4.78 
                 523.28 
               
               
                   
               
               
                 2217 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 36.2 
                 4.37 
                 543.28 
               
               
                   
               
               
                 2218 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 42.9 
                 4.1 
                 483.36 
               
               
                   
               
               
                 2219 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 46.1 
                 4.24 
                 503.30 
               
               
                   
               
               
                 2220 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 48.4 
                 3.87 
                 475.28 
               
               
                   
               
               
                 2221 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 39 
                 3.8 
                 435.34 
               
               
                   
               
               
                 2222 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 48.3 
                 4.55 
                 531.30 
               
               
                   
               
               
                 2223 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 47 
                 4.33 
                 537.20 
               
               
                   
               
               
                 2224 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 57.4 
                 4.64 
                 541.34 
               
               
                   
               
               
                 2225 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.1 
                 4.34 
                 585.37 
               
               
                   
               
               
                 2226 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.6 
                 5.36 
                 609.35 
               
               
                   
               
               
                 2227 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 40.2 
                 4.94 
                 629.34 
               
               
                   
               
               
                 2228 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.6 
                 4.57 
                 569.3 
               
               
                   
               
               
                 2229 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68 
                 4.72 
                 589.31 
               
               
                   
               
               
                 2230 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.2 
                 4.44 
                 561.31 
               
               
                   
               
               
                 2231 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.2 
                 4.37 
                 521.36 
               
               
                   
               
               
                 2232 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.7 
                 5.02 
                 617.37 
               
               
                   
               
               
                 2233 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.2 
                 4.77 
                 623.28 
               
               
                   
               
               
                 2234 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.1 
                 4.99 
                 513.23 
               
               
                   
               
               
                 2235 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.1 
                 4.98 
                 557.22 
               
               
                   
               
               
                 2236 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.8 
                 5.38 
                 581.20 
               
               
                   
               
               
                 2237 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.7 
                 4.9 
                 601.19 
               
               
                   
               
               
                 2238 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.1 
                 5.27 
                 541.23 
               
               
                   
               
               
                 2239 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.6 
                 5.45 
                 561.16 
               
               
                   
               
               
                 2240 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.6 
                 5.09 
                 533.17 
               
               
                   
               
               
                 2241 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.6 
                 5.08 
                 493.26 
               
               
                   
               
               
                 2242 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.2 
                 5.6 
                 589.22 
               
               
                   
               
               
                 2243 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70 
                 5.48 
                 595.14 
               
               
                   
               
               
                 2244 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.2 
                 5.24 
                 503.32 
               
               
                   
               
               
                 2245 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.1 
                 5.1 
                 547.30 
               
               
                   
               
               
                 2246 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.3 
                 5.65 
                 571.25 
               
               
                   
               
               
                 2247 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.7 
                 5.15 
                 591.28 
               
               
                   
               
               
                 2248 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.2 
                 5.46 
                 531.31 
               
               
                   
               
               
                 2249 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76 
                 5.58 
                 551.24 
               
               
                   
               
               
                 2250 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.2 
                 5.25 
                 523.26 
               
               
                   
               
               
                 2251 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.8 
                 5.24 
                 483.3 
               
               
                   
               
               
                 2252 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.1 
                 5.76 
                 579.31 
               
               
                   
               
               
                 2253 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.2 
                 5.66 
                 585.20 
               
               
                   
               
               
                 2254 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 36 
                 4.36 
                 495.33 
               
               
                   
               
               
                 2255 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.6 
                 3.97 
                 539.36 
               
               
                   
               
               
                 2256 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70 
                 5.0 
                 563.28 
               
               
                   
               
               
                 2257 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 50.2 
                 4.55 
                 583.28 
               
               
                   
               
               
                 2258 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 43.2 
                 4.34 
                 523.35 
               
               
                   
               
               
                 2259 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 52 
                 4.53 
                 543.29 
               
               
                   
               
               
                 2260 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 52.1 
                 4.16 
                 515.30 
               
               
                   
               
               
                 2261 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 46.2 
                 4.07 
                 475.38 
               
               
                   
               
               
                 2262 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 55.2 
                 4.82 
                 571.33 
               
               
                   
               
               
                 2263 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 51.5 
                 4.63 
                 577.22 
               
               
                   
               
               
                 2264 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.1 
                 4.49 
                 465.35 
               
               
                   
               
               
                 2265 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.1 
                 4.7 
                 481.36 
               
               
                   
               
               
                 2266 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.7 
                 4.78 
                 445.36 
               
               
                   
               
               
                 2267 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.0 
                 4.51 
                 399.29 
               
               
                   
               
               
                 2268 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.8 
                 5.39 
                 555.37 
               
               
                   
               
               
                 2269 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.5 
                 5.21 
                 485.32 
               
               
                   
               
               
                 2270 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.0 
                 5.02 
                 557.37 
               
               
                   
               
               
                 2271 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.1 
                 4.38 
                 525.37 
               
               
                   
               
               
                 2272 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.2 
                 5.42 
                 527.38 
               
               
                   
               
               
                 2273 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.0 
                 5.75 
                 537.30 
               
               
                   
               
               
                 2274 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.8 
                 5.87 
                 525.21 
               
               
                   
               
               
                 2275 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.2 
                 5.75 
                 541.16 
               
               
                   
               
               
                 2276 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.9 
                 6.11 
                 505.25 
               
               
                   
               
               
                 2277 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.5 
                 5.14 
                 459.15 
               
               
                   
               
               
                 2278 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.6 
                 6.44 
                 615.23 
               
               
                   
               
               
                 2279 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.5 
                 5.88 
                 545.10 
               
               
                   
               
               
                 2280 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.2 
                 6.43 
                 617.19 
               
               
                   
               
               
                 2281 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.4 
                 5.82 
                 585.18 
               
               
                   
               
               
                 2282 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.9 
                 6.28 
                 587.19 
               
               
                   
               
               
                 2283 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.3 
                 6.24 
                 597.14 
               
               
                   
               
               
                 2284 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.8 
                 4.02 
                 463.35 
               
               
                   
               
               
                 2285 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.8 
                 4.22 
                 479.33 
               
               
                   
               
               
                 2286 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.0 
                 4.21 
                 443.37 
               
               
                   
               
               
                 2287 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 4.2 
                 4.36 
                 397.33 
               
               
                   
               
               
                 2288 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.7 
                 4.74 
                 553.37 
               
               
                   
               
               
                 2289 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.8 
                 4.62 
                 483.29 
               
               
                   
               
               
                 2290 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.2 
                 4.52 
                 555.33 
               
               
                   
               
               
                 2291 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.3 
                 3.98 
                 523.35 
               
               
                   
               
               
                 2292 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.3 
                 4.98 
                 525.34 
               
               
                   
               
               
                 2293 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.1 
                 5.44 
                 535.29 
               
               
                   
               
               
                 2294 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59.4 
                 5.14 
                 482.30 
               
               
                   
               
               
                 2295 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.0 
                 5.09 
                 498.28 
               
               
                   
               
               
                 2296 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.3 
                 5.47 
                 462.32 
               
               
                   
               
               
                 2297 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.6 
                 4.55 
                 416.22 
               
               
                   
               
               
                 2298 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.5 
                 5.84 
                 572.32 
               
               
                   
               
               
                 2299 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.9 
                 5.3 
                 502.25 
               
               
                   
               
               
                 2300 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.7 
                 5.71 
                 574.28 
               
               
                   
               
               
                 2301 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.1 
                 5.06 
                 542.32 
               
               
                   
               
               
                 2302 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.0 
                 5.66 
                 544.29 
               
               
                   
               
               
                 2303 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.6 
                 5.62 
                 554.24 
               
               
                   
               
               
                 2304 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.2 
                 4.62 
                 435.30 
               
               
                   
               
               
                 2305 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.1 
                 4.67 
                 451.29 
               
               
                   
               
               
                 2306 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.3 
                 4.76 
                 415.32 
               
               
                   
               
               
                 2307 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 43.7 
                 4.34 
                 369.27 
               
               
                   
               
               
                 2308 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.7 
                 5.44 
                 525.34 
               
               
                   
               
               
                 2309 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.3 
                 4.96 
                 455.25 
               
               
                   
               
               
                 2310 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.7 
                 5.26 
                 527.32 
               
               
                   
               
               
                 2311 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.8 
                 4.64 
                 495.34 
               
               
                   
               
               
                 2312 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 94.1 
                 5.44 
                 497.32 
               
               
                   
               
               
                 2313 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.1 
                 5.55 
                 507.29 
               
               
                   
               
               
                 2314 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.7 
                 5.62 
                 495.16 
               
               
                   
               
               
                 2315 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 50.7 
                 5.54 
                 511.15 
               
               
                   
               
               
                 2316 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.0 
                 5.8 
                 475.22 
               
               
                   
               
               
                 2317 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 20.9 
                 4.86 
                 429.14 
               
               
                   
               
               
                 2318 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.2 
                 6.27 
                 585.15 
               
               
                   
               
               
                 2319 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 46.3 
                 5.58 
                 515.12 
               
               
                   
               
               
                 2320 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.1 
                 6.23 
                 587.20 
               
               
                   
               
               
                 2321 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.1 
                 5.64 
                 555.18 
               
               
                   
               
               
                 2322 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.8 
                 6.07 
                 557.22 
               
               
                   
               
               
                 2323 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 23.9 
                 5.96 
                 567.17 
               
               
                   
               
               
                 2324 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.1 
                 4.02 
                 433.40 
               
               
                   
               
               
                 2325 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.6 
                 4.2 
                 449.38 
               
               
                   
               
               
                 2326 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.5 
                 4.14 
                 413.39 
               
               
                   
               
               
                 2327 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 36.4 
                 3.94 
                 367.35 
               
               
                   
               
               
                 2328 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.5 
                 4.82 
                 523.39 
               
               
                   
               
               
                 2329 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.1 
                 4.42 
                 453.33 
               
               
                   
               
               
                 2330 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.7 
                 4.59 
                 525.37 
               
               
                   
               
               
                 2331 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.5 
                 4.01 
                 493.40 
               
               
                   
               
               
                 2332 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.9 
                 4.96 
                 495.39 
               
               
                   
               
               
                 2333 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.7 
                 5.3 
                 505.33 
               
               
                   
               
               
                 2334 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.9 
                 4.93 
                 425.35 
               
               
                   
               
               
                 2335 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.8 
                 4.88 
                 468.33 
               
               
                   
               
               
                 2336 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.9 
                 5.17 
                 432.36 
               
               
                   
               
               
                 2337 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 36.2 
                 4.25 
                 386.28 
               
               
                   
               
               
                 2338 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.3 
                 5.62 
                 542.36 
               
               
                   
               
               
                 2339 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.5 
                 4.96 
                 472.3 
               
               
                   
               
               
                 2340 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.9 
                 5.53 
                 544.34 
               
               
                   
               
               
                 2341 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.6 
                 4.96 
                 512.34 
               
               
                   
               
               
                 2342 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.6 
                 5.42 
                 514.35 
               
               
                   
               
               
                 2343 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.9 
                 5.34 
                 524.27 
               
               
                   
               
               
                 2344 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.9 
                 4.54 
                 431.32 
               
               
                   
               
               
                 2345 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.7 
                 5.47 
                 457.38 
               
               
                   
               
               
                 2346 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.2 
                 5.19 
                 507.34 
               
               
                   
               
               
                 2347 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.1 
                 5.38 
                 491.35 
               
               
                   
               
               
                 2348 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.7 
                 5.2 
                 495.30 
               
               
                   
               
               
                 2349 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.1 
                 5.42 
                 531.30 
               
               
                   
               
               
                 2350 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.5 
                 5.4 
                 547.27 
               
               
                   
               
               
                 2351 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.8 
                 5.58 
                 539.33 
               
               
                   
               
               
                 2352 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.3 
                 5.37 
                 469.38 
               
               
                   
               
               
                 2353 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.1 
                 5.18 
                 499.31 
               
               
                   
               
               
                 2354 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.3 
                 4.32 
                 422.33 
               
               
                   
               
               
                 2355 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.2 
                 5.26 
                 448.39 
               
               
                   
               
               
                 2356 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.7 
                 4.98 
                 498.37 
               
               
                   
               
               
                 2357 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.0 
                 5.2 
                 482.38 
               
               
                   
               
               
                 2358 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.3 
                 5.0 
                 486.34 
               
               
                   
               
               
                 2359 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.9 
                 5.26 
                 522.30 
               
               
                   
               
               
                 2360 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.7 
                 5.25 
                 538.29 
               
               
                   
               
               
                 2361 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.9 
                 5.4 
                 530.35 
               
               
                   
               
               
                 2362 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.8 
                 5.16 
                 460.38 
               
               
                   
               
               
                 2363 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.3 
                 5.03 
                 490.31 
               
               
                   
               
               
                 2364 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.5 
                 4.01 
                 441.22 
               
               
                   
               
               
                 2365 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.6 
                 4.98 
                 467.28 
               
               
                   
               
               
                 2366 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.7 
                 4.72 
                 517.25 
               
               
                   
               
               
                 2367 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.6 
                 5.0 
                 501.26 
               
               
                   
               
               
                 2368 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.3 
                 4.9 
                 505.23 
               
               
                   
               
               
                 2369 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.5 
                 5.48 
                 541.19 
               
               
                   
               
               
                 2370 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.6 
                 5.5 
                 557.19 
               
               
                   
               
               
                 2371 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.4 
                 5.53 
                 549.24 
               
               
                   
               
               
                 2372 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.3 
                 4.9 
                 479.30 
               
               
                   
               
               
                 2373 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.5 
                 5.26 
                 509.21 
               
               
                   
               
               
                 2374 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.4 
                 4.23 
                 469.37 
               
               
                   
               
               
                 2375 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.3 
                 4.94 
                 495.40 
               
               
                   
               
               
                 2376 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.1 
                 4.73 
                 545.36 
               
               
                   
               
               
                 2377 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.4 
                 4.99 
                 529.39 
               
               
                   
               
               
                 2378 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.6 
                 4.92 
                 533.35 
               
               
                   
               
               
                 2379 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.2 
                 5.62 
                 569.33 
               
               
                   
               
               
                 2380 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.2 
                 5.6 
                 585.33 
               
               
                   
               
               
                 2381 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.0 
                 5.54 
                 577.38 
               
               
                   
               
               
                 2382 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.6 
                 4.87 
                 507.41 
               
               
                   
               
               
                 2383 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.9 
                 5.42 
                 537.34 
               
               
                   
               
               
                 2384 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.2 
                 5.32 
                 455.34 
               
               
                   
               
               
                 2385 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.3 
                 5.1 
                 505.32 
               
               
                   
               
               
                 2386 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.4 
                 5.23 
                 489.33 
               
               
                   
               
               
                 2387 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.3 
                 5.12 
                 493.32 
               
               
                   
               
               
                 2388 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.4 
                 5.32 
                 529.27 
               
               
                   
               
               
                 2389 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.8 
                 5.29 
                 545.25 
               
               
                   
               
               
                 2390 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.7 
                 5.44 
                 537.33 
               
               
                   
               
               
                 2391 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.7 
                 5.24 
                 467.36 
               
               
                   
               
               
                 2392 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.3 
                 5.04 
                 497.30 
               
               
                   
               
               
                 2393 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.4 
                 4.16 
                 420.33 
               
               
                   
               
               
                 2394 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.7 
                 5.12 
                 446.38 
               
               
                   
               
               
                 2395 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.4 
                 4.88 
                 496.35 
               
               
                   
               
               
                 2396 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.0 
                 5.04 
                 480.37 
               
               
                   
               
               
                 2397 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.9 
                 4.9 
                 484.33 
               
               
                   
               
               
                 2398 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.5 
                 5.16 
                 520.29 
               
               
                   
               
               
                 2399 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.4 
                 5.12 
                 536.30 
               
               
                   
               
               
                 2400 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.0 
                 5.28 
                 528.33 
               
               
                   
               
               
                 2401 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.8 
                 5.03 
                 458.38 
               
               
                   
               
               
                 2402 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.2 
                 4.88 
                 488.30 
               
               
                   
               
               
                 2403 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.3 
                 3.88 
                 439.23 
               
               
                   
               
               
                 2404 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.8 
                 4.89 
                 465.28 
               
               
                   
               
               
                 2405 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.2 
                 4.72 
                 515.23 
               
               
                   
               
               
                 2406 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.5 
                 4.88 
                 499.27 
               
               
                   
               
               
                 2407 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.1 
                 4.88 
                 503.26 
               
               
                   
               
               
                 2408 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.8 
                 5.36 
                 539.19 
               
               
                   
               
               
                 2409 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.1 
                 5.31 
                 555.17 
               
               
                   
               
               
                 2410 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.5 
                 5.29 
                 547.22 
               
               
                   
               
               
                 2411 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.2 
                 4.86 
                 477.30 
               
               
                   
               
               
                 2412 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 55.7 
                 5.1 
                 507.20 
               
               
                   
               
               
                 2413 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.2 
                 4.12 
                 467.36 
               
               
                   
               
               
                 2414 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.6 
                 4.85 
                 493.41 
               
               
                   
               
               
                 2415 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.9 
                 4.72 
                 543.36 
               
               
                   
               
               
                 2416 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.4 
                 4.87 
                 527.39 
               
               
                   
               
               
                 2417 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.6 
                 4.92 
                 531.36 
               
               
                   
               
               
                 2418 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.6 
                 5.5 
                 567.32 
               
               
                   
               
               
                 2419 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.5 
                 5.4 
                 583.32 
               
               
                   
               
               
                 2420 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.8 
                 5.29 
                 575.36 
               
               
                   
               
               
                 2421 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.8 
                 4.82 
                 505.39 
               
               
                   
               
               
                 2422 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54.7 
                 5.29 
                 535.31 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R10 
                 R2 
                 R3 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2423 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.8 
                 3.66 
                 476.30 
               
               
                   
               
               
                 2424 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59.3 
                 3.68 
                 496.26 
               
               
                   
               
               
                 2425 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.5 
                 4.2 
                 580.22 
               
               
                   
               
               
                 2426 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 52.7 
                 3.68 
                 554.24 
               
               
                   
               
               
                 2427 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.3 
                 3.87 
                 490.30 
               
               
                   
               
               
                 2428 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.8 
                 3.85 
                 510.26 
               
               
                   
               
               
                 2429 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.0 
                 4.34 
                 594.23 
               
               
                   
               
               
                 2430 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54.1 
                 3.82 
                 568.25 
               
               
                   
               
               
                 2431 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.9 
                 3.72 
                 490.30 
               
               
                   
               
               
                 2432 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.7 
                 3.73 
                 510.26 
               
               
                   
               
               
                 2433 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.1 
                 4.23 
                 594.24 
               
               
                   
               
               
                 2434 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 52.7 
                 3.72 
                 568.24 
               
               
                   
               
               
                 2435 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.6 
                 3.92 
                 504.32 
               
               
                   
               
               
                 2436 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.8 
                 3.9 
                 524.28 
               
               
                   
               
               
                 2437 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.2 
                 4.37 
                 608.24 
               
               
                   
               
               
                 2438 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59.3 
                 3.86 
                 582.27 
               
               
                   
               
               
                 2439 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.3 
                 3.9 
                 544.32 
               
               
                   
               
               
                 2440 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.4 
                 3.91 
                 564.29 
               
               
                   
               
               
                 2441 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.8 
                 4.41 
                 648.30 
               
               
                   
               
               
                 2442 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 57.6 
                 3.92 
                 622.31 
               
               
                   
               
               
                 2443 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.8 
                 4.09 
                 558.34 
               
               
                   
               
               
                 2444 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.5 
                 4.08 
                 578.30 
               
               
                   
               
               
                 2445 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.3 
                 4.5 
                 662.31 
               
               
                   
               
               
                 2446 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 47.6 
                 4.04 
                 636.36 
               
               
                   
               
               
                 2447 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.6 
                 3.88 
                 538.28 
               
               
                   
               
               
                 2448 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.2 
                 3.9 
                 558.24 
               
               
                   
               
               
                 2449 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59.8 
                 4.38 
                 642.27 
               
               
                   
               
               
                 2450 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 48.4 
                 3.88 
                 616.30 
               
               
                   
               
               
                 2451 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.9 
                 4.06 
                 552.28 
               
               
                   
               
               
                 2452 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59.4 
                 4.04 
                 572.25 
               
               
                   
               
               
                 2453 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.4 
                 4.52 
                 656.29 
               
               
                   
               
               
                 2454 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 50.0 
                 4.02 
                 630.31 
               
               
                   
               
               
                 2455 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.1 
                 3.74 
                 488.29 
               
               
                   
               
               
                 2456 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.3 
                 3.72 
                 508.25 
               
               
                   
               
               
                 2457 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.2 
                 4.21 
                 592.22 
               
               
                   
               
               
                 2458 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.1 
                 3.71 
                 566.24 
               
               
                   
               
               
                 2459 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.4 
                 3.96 
                 502.32 
               
               
                   
               
               
                 2460 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.5 
                 3.89 
                 522.27 
               
               
                   
               
               
                 2461 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.6 
                 4.37 
                 606.26 
               
               
                   
               
               
                 2462 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.2 
                 3.8 
                 580.26 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R10 
                 R2 
                 R3 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2463 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.6 
                 3.96 
                 487.31 
               
               
                   
               
               
                 2464 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.7 
                 4 
                 507.27 
               
               
                   
               
               
                 2465 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.9 
                 4.48 
                 591.22 
               
               
                   
               
               
                 2466 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 40.3 
                 4 
                 565.25 
               
               
                   
               
               
                 2467 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.3 
                 4.12 
                 501.31 
               
               
                   
               
               
                 2468 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.2 
                 4.14 
                 521.25 
               
               
                   
               
               
                 2469 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.4 
                 4.62 
                 605.25 
               
               
                   
               
               
                 2470 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33.1 
                 4.13 
                 579.27 
               
               
                   
               
               
                 2471 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.3 
                 4.01 
                 501.31 
               
               
                   
               
               
                 2472 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54.0 
                 4.05 
                 521.25 
               
               
                   
               
               
                 2473 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.1 
                 4.51 
                 605.26 
               
               
                   
               
               
                 2474 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35.4 
                 4.04 
                 579.27 
               
               
                   
               
               
                 2475 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.4 
                 4.18 
                 515.31 
               
               
                   
               
               
                 2476 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68.0 
                 4.19 
                 535.28 
               
               
                   
               
               
                 2477 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.9 
                 4.64 
                 619.25 
               
               
                   
               
               
                 2478 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 32.6 
                 4.17 
                 593.28 
               
               
                   
               
               
                 2479 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.7 
                 4.18 
                 555.33 
               
               
                   
               
               
                 2480 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59.4 
                 4.24 
                 575.29 
               
               
                   
               
               
                 2481 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.8 
                 4.72 
                 659.33 
               
               
                   
               
               
                 2482 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 36.4 
                 4.2 
                 633.44 
               
               
                   
               
               
                 2483 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 92.4 
                 4.36 
                 569.34 
               
               
                   
               
               
                 2484 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.9 
                 4.38 
                 589.32 
               
               
                   
               
               
                 2485 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.9 
                 4.82 
                 673.33 
               
               
                   
               
               
                 2486 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 32.2 
                 4.36 
                 647.19 
               
               
                   
               
               
                 2487 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.2 
                 4.14 
                 549.28 
               
               
                   
               
               
                 2488 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59.7 
                 4.22 
                 569.24 
               
               
                   
               
               
                 2489 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.6 
                 4.7 
                 653.25 
               
               
                   
               
               
                 2490 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 34.5 
                 4.22 
                 627.27 
               
               
                   
               
               
                 2491 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.3 
                 4.32 
                 563.30 
               
               
                   
               
               
                 2492 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.8 
                 4.35 
                 583.26 
               
               
                   
               
               
                 2493 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.3 
                 4.8 
                 667.27 
               
               
                   
               
               
                 2494 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 32.9 
                 4.34 
                 641.29 
               
               
                   
               
               
                 2495 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.4 
                 3.94 
                 499.30 
               
               
                   
               
               
                 2496 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.0 
                 3.92 
                 519.24 
               
               
                   
               
               
                 2497 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.4 
                 4.41 
                 603.24 
               
               
                   
               
               
                 2498 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.4 
                 3.94 
                 577.26 
               
               
                   
               
               
                 2499 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.9 
                 4.12 
                 513.31 
               
               
                   
               
               
                 2500 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.5 
                 4.09 
                 533.26 
               
               
                   
               
               
                 2501 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.6 
                 4.54 
                 617.26 
               
               
                   
               
               
                 2502 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.4 
                 4.09 
                 591.27 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R10 
                 R2 
                 R3 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2503 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.7 
                 3.8 
                 471.39 
               
               
                   
               
               
                 2504 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 37.7 
                 3.82 
                 491.34 
               
               
                   
               
               
                 2505 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.7 
                 4.09 
                 525.28 
               
               
                   
               
               
                 2506 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.5 
                 4.23 
                 541.33 
               
               
                   
               
               
                 2507 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.6 
                 4.0 
                 485.38 
               
               
                   
               
               
                 2508 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.2 
                 4.0 
                 505.34 
               
               
                   
               
               
                 2509 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.3 
                 4.25 
                 539.29 
               
               
                   
               
               
                 2510 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.2 
                 4.37 
                 555.34 
               
               
                   
               
               
                 2511 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 57.5 
                 3.56 
                 417.32 
               
               
                   
               
               
                 2512 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.9 
                 3.56 
                 437.27 
               
               
                   
               
               
                 2513 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.0 
                 3.85 
                 471.26 
               
               
                   
               
               
                 2514 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.1 
                 4.0 
                 487.33 
               
               
                   
               
               
                 2515 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.4 
                 3.76 
                 431.34 
               
               
                   
               
               
                 2516 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.8 
                 3.75 
                 451.30 
               
               
                   
               
               
                 2517 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.2 
                 4.02 
                 485.27 
               
               
                   
               
               
                 2518 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.4 
                 4.16 
                 501.32 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R10 
                 R2 
                 R3 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2519 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.4 
                 3.73 
                 471.38 
               
               
                   
               
               
                 2520 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.9 
                 3.76 
                 491.33 
               
               
                   
               
               
                 2521 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.0 
                 4.04 
                 525.28 
               
               
                   
               
               
                 2522 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.2 
                 4.17 
                 541.34 
               
               
                   
               
               
                 2523 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.9 
                 3.94 
                 485.39 
               
               
                   
               
               
                 2524 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.2 
                 3.94 
                 505.34 
               
               
                   
               
               
                 2525 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.1 
                 4.2 
                 539.30 
               
               
                   
               
               
                 2526 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.9 
                 4.33 
                 555.34 
               
               
                   
               
               
                 2527 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.7 
                 3.51 
                 417.32 
               
               
                   
               
               
                 2528 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 50.3 
                 3.52 
                 437.28 
               
               
                   
               
               
                 2529 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.4 
                 3.8 
                 471.26 
               
               
                   
               
               
                 2530 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.5 
                 3.96 
                 487.32 
               
               
                   
               
               
                 2531 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.4 
                 3.72 
                 431.32 
               
               
                   
               
               
                 2532 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 68 
                 3.71 
                 451.29 
               
               
                   
               
               
                 2533 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.6 
                 3.98 
                 485.26 
               
               
                   
               
               
                 2534 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.9 
                 4.12 
                 501.32 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R10 
                 R2 
                 R3 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2535 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.7 
                 3.83 
                 505.34 
               
               
                   
               
               
                 2536 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.2 
                 3.89 
                 525.30 
               
               
                   
               
               
                 2537 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.9 
                 4.17 
                 559.25 
               
               
                   
               
               
                 2538 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.4 
                 4.29 
                 575.30 
               
               
                   
               
               
                 2539 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.9 
                 4.03 
                 519.35 
               
               
                   
               
               
                 2540 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.5 
                 4.04 
                 539.31 
               
               
                   
               
               
                 2541 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.2 
                 4.31 
                 573.25 
               
               
                   
               
               
                 2542 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.6 
                 4.43 
                 589.33 
               
               
                   
               
               
                 2543 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.2 
                 3.62 
                 451.30 
               
               
                   
               
               
                 2544 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.9 
                 3.65 
                 471.27 
               
               
                   
               
               
                 2545 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.8 
                 3.92 
                 505.22 
               
               
                   
               
               
                 2546 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.7 
                 4.06 
                 521.26 
               
               
                   
               
               
                 2547 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.5 
                 3.82 
                 465.31 
               
               
                   
               
               
                 2548 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.9 
                 3.82 
                 485.28 
               
               
                   
               
               
                 2549 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33.1 
                 4.1 
                 519.23 
               
               
                   
               
               
                 2550 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 51.2 
                 4.22 
                 535.28 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R10 
                 R2 
                 R3 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2551 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.8 
                 3.45 
                 521.33 
               
               
                   
               
               
                 2552 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.6 
                 4.14 
                 541.29 
               
               
                   
               
               
                 2553 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.7 
                 3.79 
                 575.24 
               
               
                   
               
               
                 2554 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.8 
                 3.93 
                 591.31 
               
               
                   
               
               
                 2555 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.2 
                 3.65 
                 535.35 
               
               
                   
               
               
                 2556 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.6 
                 3.66 
                 555.29 
               
               
                   
               
               
                 2557 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.3 
                 3.94 
                 589.26 
               
               
                   
               
               
                 2558 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.7 
                 4.06 
                 605.35 
               
               
                   
               
               
                 2559 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.1 
                 3.22 
                 467.29 
               
               
                   
               
               
                 2560 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.7 
                 3.26 
                 487.27 
               
               
                   
               
               
                 2561 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.6 
                 3.56 
                 521.20 
               
               
                   
               
               
                 2562 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.5 
                 3.72 
                 537.27 
               
               
                   
               
               
                 2563 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.1 
                 3.42 
                 481.31 
               
               
                   
               
               
                 2564 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.1 
                 3.43 
                 501.29 
               
               
                   
               
               
                 2565 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.0 
                 3.73 
                 535.22 
               
               
                   
               
               
                 2566 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.9 
                 3.86 
                 551.28 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R10 
                 R2 
                 R3 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2567 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.0 
                 3.99 
                 535.3 
               
               
                   
               
               
                 2568 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 40.6 
                 4.04 
                 555.31 
               
               
                   
               
               
                 2569 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 47.5 
                 4.31 
                 589.26 
               
               
                   
               
               
                 2570 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 37.4 
                 4.43 
                 605.33 
               
               
                   
               
               
                 2571 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.3 
                 4.18 
                 549.35 
               
               
                   
               
               
                 2572 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 38.8 
                 4.19 
                 569.30 
               
               
                   
               
               
                 2573 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 51.6 
                 4.46 
                 603.28 
               
               
                   
               
               
                 2574 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 36 
                 4.55 
                 619.35 
               
               
                   
               
               
                 2575 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.4 
                 3.77 
                 481.30 
               
               
                   
               
               
                 2576 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 37.9 
                 3.81 
                 501.28 
               
               
                   
               
               
                 2577 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 45.6 
                 4.08 
                 535.21 
               
               
                   
               
               
                 2578 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 34.9 
                 4.2 
                 551.27 
               
               
                   
               
               
                 2579 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.2 
                 3.95 
                 495.31 
               
               
                   
               
               
                 2580 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 44.8 
                 3.96 
                 515.25 
               
               
                   
               
               
                 2581 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54.4 
                 4.23 
                 549.24 
               
               
                   
               
               
                 2582 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 36.5 
                 4.34 
                 565.28 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R10 
                 R2 
                 R3 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2583 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 52.2 
                 3.91 
                 465.24 
               
               
                   
               
               
                 2584 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 55.9 
                 4 
                 529.14 
               
               
                   
               
               
                 2585 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 51.3 
                 3.9 
                 445.29 
               
               
                   
               
               
                 2586 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 57.4 
                 3.9 
                 510.24 
               
               
                   
               
               
                 2587 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54.3 
                 4.04 
                 479.28 
               
               
                   
               
               
                 2588 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.7 
                 4.12 
                 543.15 
               
               
                   
               
               
                 2589 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.0 
                 3.82 
                 465.25 
               
               
                   
               
               
                 2590 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.6 
                 3.85 
                 530.20 
               
               
                   
               
               
                 2591 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.1 
                 3.97 
                 499.25 
               
               
                   
               
               
                 2592 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.3 
                 4.06 
                 563.1 
               
               
                   
               
               
                 2593 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 84.2 
                 3.96 
                 479.29 
               
               
                   
               
               
                 2594 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.8 
                 3.98 
                 544.20 
               
               
                   
               
               
                 2595 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.5 
                 4.1 
                 513.26 
               
               
                   
               
               
                 2596 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.5 
                 4.19 
                 577.1 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R10 
                 R2 
                 R3 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2597 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 28.6 
                 3.7 
                 514.16 
               
               
                   
               
               
                 2598 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 39.0 
                 3.83 
                 483.24 
               
               
                   
               
               
                 2599 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 39.9 
                 3.92 
                 547.1 
               
               
                   
               
               
                 2600 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 53.5 
                 3.8 
                 463.26 
               
               
                   
               
               
                 2601 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 28.8 
                 3.83 
                 528.19 
               
               
                   
               
               
                 2602 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 31.0 
                 3.96 
                 497.24 
               
               
                   
               
               
                 2603 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 34.0 
                 4.05 
                 561.1 
               
               
                   
               
               
                 2604 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.5 
                 3.72 
                 483.24 
               
               
                   
               
               
                 2605 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 25.4 
                 3.78 
                 548.12 
               
               
                   
               
               
                 2606 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 36.8 
                 3.9 
                 517.20 
               
               
                   
               
               
                 2607 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 31.2 
                 4 
                 581.1 
               
               
                   
               
               
                 2608 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.8 
                 3.86 
                 497.24 
               
               
                   
               
               
                 2609 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 31.7 
                 3.9 
                 562.17 
               
               
                   
               
               
                 2610 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 40.1 
                 4.02 
                 531.21 
               
               
                   
               
               
                 2611 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 38.2 
                 4.12 
                 595.1 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R10 
                 R2 
                 R3 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2612 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 45.2 
                 3.49 
                 419.24 
               
               
                   
               
               
                 2613 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56.6 
                 3.39 
                 439.21 
               
               
                   
               
               
                 2614 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.6 
                 3.56 
                 453.23 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R10 
                 R2 
                 R3 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2615 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.5 
                 3.96 
                 479.28 
               
               
                   
               
               
                 2616 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 50.5 
                 4 
                 544.19 
               
               
                   
               
               
                 2617 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 55.7 
                 4.11 
                 513.26 
               
               
                   
               
               
                 2618 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 55.5 
                 4.2 
                 577.13 
               
               
                   
               
               
                 2619 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.1 
                 4.09 
                 493.30 
               
               
                   
               
               
                 2620 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 53.7 
                 4.11 
                 558.20 
               
               
                   
               
               
                 2621 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 55.5 
                 4.22 
                 527.27 
               
               
                   
               
               
                 2622 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.1 
                 4.3 
                 591.13 
               
               
                   
               
               
                 2623 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.1 
                 4.02 
                 513.26 
               
               
                   
               
               
                 2624 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 51.0 
                 4.08 
                 578.18 
               
               
                   
               
               
                 2625 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54.1 
                 4.17 
                 547.21 
               
               
                   
               
               
                 2626 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.2 
                 4.26 
                 611.11 
               
               
                   
               
               
                 2627 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.9 
                 4.16 
                 527.27 
               
               
                   
               
               
                 2628 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.2 
                 4.18 
                 592.21 
               
               
                   
               
               
                 2629 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63 
                 4.3 
                 561.21 
               
               
                   
               
               
                 2630 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.0 
                 4.36 
                 625.11 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R10 
                 R2 
                 R3 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2631 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.1 
                 4.06 
                 515.26 
               
               
                   
               
               
                 2632 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 57.8 
                 4.13 
                 580.20 
               
               
                   
               
               
                 2633 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 37.4 
                 4.22 
                 549.23 
               
               
                   
               
               
                 2634 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 43.3 
                 4.31 
                 613.12 
               
               
                   
               
               
                 2635 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.7 
                 4.18 
                 529.27 
               
               
                   
               
               
                 2636 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.3 
                 4.22 
                 594.19 
               
               
                   
               
               
                 2637 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 37.0 
                 4.32 
                 563.25 
               
               
                   
               
               
                 2638 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 44.3 
                 4.4 
                 627.15 
               
               
                   
               
               
                 2639 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.9 
                 4.14 
                 549.23 
               
               
                   
               
               
                 2640 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 53.4 
                 4.23 
                 614.17 
               
               
                   
               
               
                 2641 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 37 
                 4.3 
                 583.21 
               
               
                   
               
               
                 2642 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 45.7 
                 4.4 
                 647.11 
               
               
                   
               
               
                 2643 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.9 
                 4.24 
                 563.25 
               
               
                   
               
               
                 2644 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 57.3 
                 4.3 
                 628.19 
               
               
                   
               
               
                 2645 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 39.4 
                 4.39 
                 597.22 
               
               
                   
               
               
                 2646 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 44.1 
                 4.48 
                 661.15 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R10 
                 R2 
                 R3 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2647 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 25.6 
                 3.18 
                 495.23 
               
               
                   
               
               
                 2648 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33.1 
                 3.59 
                 533.15 
               
               
                   
               
               
                 2649 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 27.0 
                 3 
                 490.2 
               
               
                   
               
               
                 2650 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33.6 
                 3.14 
                 562.16 
               
               
                   
               
               
                 2651 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 27.2 
                 3.36 
                 509.21 
               
               
                   
               
               
                 2652 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 32.5 
                 3.76 
                 547.16 
               
               
                   
               
               
                 2653 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 29.7 
                 3.2 
                 504.2 
               
               
                   
               
               
                 2654 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 34.8 
                 3.32 
                 576.21 
               
               
                   
               
               
                 2655 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.7 
                 2.93 
                 439.15 
               
               
                   
               
               
                 2656 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 60.6 
                 3.37 
                 477.14 
               
               
                   
               
               
                 2657 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.1 
                 2.7 
                 434.1 
               
               
                   
               
               
                 2658 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.3 
                 2.92 
                 506.14 
               
               
                   
               
               
                 2659 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 72.5 
                 3.14 
                 453.17 
               
               
                   
               
               
                 2660 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.2 
                 3.55 
                 491.14 
               
               
                   
               
               
                 2661 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.4 
                 2.9 
                 448.1 
               
               
                   
               
               
                 2662 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.9 
                 3.14 
                 520.15 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R10 
                 R2 
                 R3 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2663 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.3 
                 3.82 
                 555.21 
               
               
                   
               
               
                 2664 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.8 
                 4.24 
                 593.19 
               
               
                   
               
               
                 2665 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.5 
                 3.8 
                 550.2 
               
               
                   
               
               
                 2666 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.1 
                 3.78 
                 622.22 
               
               
                   
               
               
                 2667 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.1 
                 3.98 
                 569.21 
               
               
                   
               
               
                 2668 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.2 
                 4.35 
                 607.21 
               
               
                   
               
               
                 2669 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.9 
                 3.9 
                 564.2 
               
               
                   
               
               
                 2670 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.1 
                 3.94 
                 636.25 
               
               
                   
               
               
                 2671 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.0 
                 3.55 
                 499.18 
               
               
                   
               
               
                 2672 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.2 
                 3.93 
                 537.14 
               
               
                   
               
               
                 2673 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.4 
                 3.4 
                 494.2 
               
               
                   
               
               
                 2674 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.4 
                 3.52 
                 566.15 
               
               
                   
               
               
                 2675 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.0 
                 3.72 
                 513.19 
               
               
                   
               
               
                 2676 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.8 
                 4.08 
                 551.15 
               
               
                   
               
               
                 2677 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 88.9 
                 3.6 
                 508.2 
               
               
                   
               
               
                 2678 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 93.6 
                 3.7 
                 580.17 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R10 
                 R2 
                 R3 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2679 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59.5 
                 4 
                 569.20 
               
               
                   
               
               
                 2680 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82.6 
                 4.37 
                 607.21 
               
               
                   
               
               
                 2681 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.9 
                 3.9 
                 564.2 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R10 
                 R2 
                 R3 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2718 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.9 
                 3.92 
                 675.26 
               
               
                   
               
               
                 2719 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 75.5 
                 3.63 
                 538.18 
               
               
                   
               
               
                 2720 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.4 
                 3.96 
                 576.13 
               
               
                   
               
               
                 2721 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73 
                 3.5 
                 533.2 
               
               
                   
               
               
                 2722 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.0 
                 3.56 
                 605.17 
               
               
                   
               
               
                 2723 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.8 
                 3.8 
                 552.18 
               
               
                   
               
               
                 2724 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80.1 
                 4.11 
                 590.15 
               
               
                   
               
               
                 2725 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.4 
                 3.6 
                 547.2 
               
               
                   
               
               
                 2726 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.3 
                 3.73 
                 619.18 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R2 
                 R3 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                 2727 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.7 
                 4.7 
                 488.3 
               
               
                   
               
               
                 2728 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.1 
                 4.2 
                 508.2 
               
               
                   
               
               
                 2729 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 90.3 
                 4.3 
                 522.3 
               
               
                   
               
               
                 2730 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 78.2 
                 4.5 
                 586.1 
               
               
                   
               
               
                 2731 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73 
                 4.1 
                 533.2 
               
               
                   
               
               
                 2732 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.4 
                 4.5 
                 542.2 
               
               
                   
               
               
                 2733 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.7 
                 4.6 
                 576.2 
               
               
                   
               
               
                 2734 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 80 
                 4.7 
                 592.2 
               
               
                   
               
               
                 2735 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.4 
                 4.9 
                 644.2 
               
               
                   
               
               
                 2736 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.4 
                 4.6 
                 558.2 
               
               
                   
               
               
                 2737 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.8 
                 4.4 
                 502.3 
               
               
                   
               
               
                 2738 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 87.5 
                 4.4 
                 522.3 
               
               
                   
               
               
                 2739 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 91.4 
                 4.5 
                 536.3 
               
               
                   
               
               
                 2740 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.3 
                 4.6 
                 600.1 
               
               
                   
               
               
                 2741 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 4.3 
                 547.2 
               
               
                   
               
               
                 2742 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 83.9 
                 4.6 
                 556.2 
               
               
                   
               
               
                 2743 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.4 
                 4.7 
                 590.2 
               
               
                   
               
               
                 2744 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.2 
                 4.8 
                 606.2 
               
               
                   
               
               
                 2745 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 4.3 
                 658.2 
               
               
                   
               
               
                 2746 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 86.7 
                 4.7 
                 572.2 
               
               
                   
               
               
                 2747 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 31.6 
                 4.3 
                 506.3 
               
               
                   
               
               
                 2748 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.1 
                 4.3 
                 526.2 
               
               
                   
               
               
                 2749 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 89.5 
                 4.4 
                 540.2 
               
               
                   
               
               
                 2750 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59.6 
                 4.5 
                 604.1 
               
               
                   
               
               
                 2751 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 51.3 
                 4.2 
                 551.2 
               
               
                   
               
               
                 2752 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.2 
                 4.5 
                 560.2 
               
               
                   
               
               
                 2753 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 59.6 
                 4.7 
                 594.2 
               
               
                   
               
               
                 2754 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63 
                 4.7 
                 610.2 
               
               
                   
               
               
                 2755 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 52.5 
                 4.9 
                 662.2 
               
               
                   
               
               
                 2756 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.8 
                 4.6 
                 576.1 
               
               
                   
               
               
                 2757 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.1 
                 4.6 
                 516.3 
               
               
                   
               
               
                 2758 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.8 
                 4.5 
                 536.3 
               
               
                   
               
               
                 2759 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.4 
                 4.7 
                 550.3 
               
               
                   
               
               
                 2760 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 76.6 
                 4.7 
                 614.1 
               
               
                   
               
               
                 2761 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 77.2 
                 4.4 
                 561.2 
               
               
                   
               
               
                 2762 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 85.4 
                 4.7 
                 570.2 
               
               
                   
               
               
                 2763 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.7 
                 4.8 
                 604.2 
               
               
                   
               
               
                 2764 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 81.1 
                 4.9 
                 620.2 
               
               
                   
               
               
                 2765 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 79.2 
                 5.1 
                 672.2 
               
               
                   
               
               
                 2766 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 82 
                 4.8 
                 586.3 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Pur- 
                   
                   
               
               
                   
                   
                   
                   
                 ity 
                   
                 [M + 
               
               
                 Ex. 
                 R10 
                 R2 
                 R3 
                 (%) 
                 rt (min.) 
                 H] +   
               
               
                   
               
               
                 2767 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 64.3 
                 3.91 
                 530.20 
               
               
                   
               
               
                 2768 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 58.3 
                 3.57 
                 521.22 
               
               
                   
               
               
                 2769 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.7 
                 4.03 
                 564.20 
               
               
                   
               
               
                 2770 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 65.1 
                 3.71 
                 541.19 
               
               
                   
               
               
                 2771 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56.1 
                 3.58 
                 521.21 
               
               
                   
               
               
                 2772 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 42.1 
                 3.93 
                 544.19 
               
               
                   
               
               
                 2773 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 34.6 
                 3.59 
                 535.22 
               
               
                   
               
               
                 2774 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 46.9 
                 4.05 
                 578.21 
               
               
                   
               
               
                 2775 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33.3 
                 3.73 
                 555.19 
               
               
                   
               
               
                 2776 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33.4 
                 3.6 
                 535.22 
               
               
                   
               
               
                 2777 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 39.6 
                 3.97 
                 558.22 
               
               
                   
               
               
                 2778 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 47.5 
                 3.63 
                 549.23 
               
               
                   
               
               
                 2779 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 50.3 
                 4.09 
                 592.23 
               
               
                   
               
               
                 2780 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 40.6 
                 3.76 
                 569.19 
               
               
                   
               
               
                 2781 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 42.7 
                 3.63 
                 549.25 
               
               
                   
               
               
                 2782 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 35.5 
                 4.0 
                 572.17 
               
               
                   
               
               
                 2783 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 33.2 
                 3.69 
                 563.26 
               
               
                   
               
               
                 2784 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 45 
                 4.1 
                 606.27 
               
               
                   
               
               
                 2785 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 36.0 
                 3.82 
                 583.23 
               
               
                   
               
               
                 2786 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 27.1 
                 3.7 
                 563.26 
               
               
                   
               
               
                 2787 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 73.6 
                 3.98 
                 530.19 
               
               
                   
               
               
                 2788 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.5 
                 3.64 
                 521.21 
               
               
                   
               
               
                 2789 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 74.8 
                 4.09 
                 564.2 
               
               
                   
               
               
                 2790 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 67.7 
                 3.77 
                 541.20 
               
               
                   
               
               
                 2791 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 71.3 
                 3.65 
                 521.21 
               
               
                   
               
               
                 2792 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 52.4 
                 4.0 
                 544.18 
               
               
                   
               
               
                 2793 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 47.0 
                 3.65 
                 535.22 
               
               
                   
               
               
                 2794 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54.7 
                 4.11 
                 578.22 
               
               
                   
               
               
                 2795 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 43.7 
                 3.79 
                 555.20 
               
               
                   
               
               
                 2796 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 44.6 
                 3.67 
                 535.22 
               
               
                   
               
               
                 2797 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 53.7 
                 4.03 
                 558.20 
               
               
                   
               
               
                 2798 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 51.0 
                 3.69 
                 549.23 
               
               
                   
               
               
                 2799 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56.5 
                 4.15 
                 592.23 
               
               
                   
               
               
                 2800 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 48.9 
                 3.83 
                 569.20 
               
               
                   
               
               
                 2801 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 46.0 
                 3.7 
                 549.24 
               
               
                   
               
               
                 2802 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 41.2 
                 4.1 
                 572.21 
               
               
                   
               
               
                 2803 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 36.7 
                 3.76 
                 563.26 
               
               
                   
               
               
                 2804 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 47.4 
                 4.2 
                 606.26 
               
               
                   
               
               
                 2805 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 37.0 
                 3.89 
                 583.22 
               
               
                   
               
               
                 2806 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 37.3 
                 3.76 
                 563.26 
               
               
                   
               
            
           
           
               
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Ex. 
                 R3 
                 R2 
                 Purity (%) 
                 rt (min.) 
                 [M + H] +   
               
               
                   
               
               
                 2807 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 52.1 
                 3.65 
                 547.22 
               
               
                   
               
               
                 2808 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 61.7 
                 3.61 
                 563.24 
               
               
                   
               
               
                 2809 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54.1 
                 3.91 
                 561.26 
               
               
                   
               
               
                 2810 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56.7 
                 3.69 
                 563.23 
               
               
                   
               
               
                 2811 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 54.7 
                 3.65 
                 547.23 
               
               
                   
               
               
                 2812 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 63.6 
                 3.96 
                 561.25 
               
               
                   
               
               
                 2813 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 66.1 
                 4.13 
                 575.26 
               
               
                   
               
               
                 2814 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 34.9 
                 4.29 
                 589.29 
               
               
                   
               
               
                 2815 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 69.3 
                 3.66 
                 563.24 
               
               
                   
               
               
                 2816 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 47.6 
                 3.66 
                 547.23 
               
               
                   
               
               
                 2817 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 41.4 
                 3.61 
                 563.23 
               
               
                   
               
               
                 2818 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 28.5 
                 3.97 
                 561.24 
               
               
                   
               
               
                 2819 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 56.4 
                 3.71 
                 563.23 
               
               
                   
               
               
                 2820 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 45.6 
                 3.65 
                 547.22 
               
               
                   
               
               
                 2821 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 62.6 
                 3.99 
                 561.24 
               
               
                   
               
               
                 2822 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 42.0 
                 4.17 
                 575.26 
               
               
                   
               
               
                 2823 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 45.7 
                 4.32 
                 589.28 
               
               
                   
               
               
                 2824 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 23.5 
                 3.65 
                 551.21 
               
               
                   
               
               
                 2825 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 70.9 
                 3.67 
                 563.22 
               
               
                   
               
            
           
         
       
     
     Some compounds according to the invention can be obtained according to method G described hereafter. 
     Method G 
     Synthesis in solution of 2-iminothiazole-4-carboxamide derivatives from monoprotected symmetrical diamines (Boc) 
                         
General Procedure:
 
     The monoprotected symmetrical diamine (Boc) (1 equiv) is agitated overnight with an aromatic isothiocyanate (1 equiv) at ambient temperature in an anhydrous solvent such as dioxane, dimethylformamide or chloroform, 1 equivalent of an inorganic base such as sodium or potassium hydrogen carbonate and 1 equivalent of ethyl bromopyruvate dissolved beforehand in an anhydrous solvent such as dioxane or dimethylformamide is successively added to the crude isothiourea intermediate. The mixture is then heated at 80° C. for 1 to 3 hours and the inorganic salts are eliminated by filtration. The solvents are evaporated off under vacuum and the residue is purified by flash chromatography on silica gel using an ethyl acetate/heptane gradient. Saponification of the ester intermediate is carried out in a solvent such as tetrahydrofuran using a 1N solution of KOH, LiOH or NaOH. The mixture is agitated vigorously for 6 to 20 hours at ambient temperature then acidified with a 1N aqueous solution of hydrochloric acid to pH 2.5. 
     The organic phase is extracted several times with dichloromethane then the organic phase is washed with water until neutral pH and dried over sodium sulphate. A primary or secondary amine (1.1 to 2 equiv.) pre-dissolved in a anhydrous solvent such as dimethylformamide is added under argon to a solution of carboxylic acid intermediate (1 equiv.) and a peptide coupling agent such as DIC, DIC/HOBt, HATU or TBTU (1.1 to 2 equiv.), dissolved beforehand in an anhydrous solvent such as dimethylformamide. The mixture is agitated overnight at ambient temperature. The solvent is evaporated off under vacuum and the residue purified by flash chromatography on silica gel using an ethyl acetate/heptane gradient. The carboxamide intermediate is diluted in a solvent such as dichloromethane or ethyl acetate and deprotected after passage through the solution of a current of dry hydrogen chloride for 1 to 6 hours at ambient temperature. The corresponding dihydrochloride is isolated either by filtration of the precipitate or, after evaporation under vacuum of the solvent, by adding diethylether for better crystallisation. 
     Preparation 25 
     ethyl(2Z)-3-{5-[(tert-butoxycarbonyl)amino]pentyl}-2-[(3,5-dimethylphenyl)imino]-2,3-dihydro-1,3-thiazole-4-carboxylate 
     (C 14 H 25 N 3 O 4 S; MM=461.63) 
     
       
         
         
             
             
         
       
     
     N-Boc-1,5-diaminopentane (1.04 g; 5 mmol) is agitated with 3,5-dimethylisothiocyanate (824 mg; 5 mmol) in 10 ml anhydrous dioxane. 420 mg (5 mmol) of sodium hydrogen carbonate and 1.08 g (5 mmol) of ethyl bromopyruvate dissolved beforehand in 2 ml of anhydrous dioxane are successively added to the, crude isothiourea intermediate. The mixture is then heated at 80° C. for one hour and the inorganic salts are eliminated by filtration. The dioxane is evaporated off under vacuum and the yellow residue is purified by flash chromatography on silica gel (eluent:ethyl acetate/heptane 2:8 then 3:7). A yellow oil (1.8 g; yield of 77.9%) corresponding to the expected compound is then isolated. 
     NMR  1 H (DMSO-d 6 , 400 MHz) δ: 7.23 (s, 1H); 6.71 (broad s, 1H); 6.65 (s, 1H); 6.54 (s, 2H); 4.26 (q, 2H, J=6.4 Hz); 4.13 (t, 2H, J=6.4 Hz); 2.9 (q, 2H, J=6 Hz); 2.22 (s, 6H); 1.63 (m, 2H); 1.4 (m, 2H); 1.36 (s, 9H); 1.29–1.23 (m, 2H+3H). MS/LC: m/z=462.3 (M+H) + . 
     Preparation 26 
     (2Z)-3-{5-[(ten-buroxycarbonyl)amino]pentyl}-2-[(3,5-dimethylphenyl)imino]=2,3-dihydro-1,3-thiazole-4-carboxylic acid 
     (C 22 H 31 N 3 O 4 S; MM=433.57) 
     
       
         
         
             
             
         
       
     
     The compound of Preparation 25 (1.77; 3.83 mmol) is dissolved in 20 ml of tetrahydrofuran and treated with 15 ml of a 1N aqueous solution of NaOH. The mixture is agitated vigorously for 6 hours at ambient temperature. The carboxylate is then acidified with a 1N aqueous solution of hydrochloric acid to pH 2.5. The aqueous phase is extracted with dichloromethane (4×50 ml) and the organic phases are washed with water until neutral pH and dried over sodium sulphate. A pale yellow solid is isolated (1.51 g; yield of 90.9%) after evaporation under vacuum of the solvents. 
     NMR  1 H (DMSO-d 6 , 400 MHz) δ: 13.28 (broad s, 1H); 7.16 (s, 1H); 6.69 (broad s, 1H); 6.65 (s, 1H); 6.54 (s, 2H); 4.17 (t, 2H, J=7.2 Hz); 2.89 (q, 2H, J=6.4 Hz); 2.22 (s, 6H); 1.63 (q, 2H, J=6.8 Hz); 1.41 (m, 2H); 1.36 (s, 9H); 1.25 (m, 2H). MS/LC: m/z=434.27 (M+H) +   
     Preparation 27 
     tert-butyl 5-[(2Z)-2-[(3,5-dimethylphenyl)imino]-4-{[(1-phenylpropyl)amino]carbonyl}-1,3-thiazol-3(2H)-yl]pentylcarbamate 
     (C 31 H 42 N 4 O 3 S; MM=550.76) 
     
       
         
         
             
             
         
       
     
     600 mg (1.38 mmol) of carboxylic acid of Preparation 26 are activated beforehand with 888 mg (2.76 mmol; 2 equiv.) of TBTU in 10 ml of anhydrous dimethylformamide for one hour. 410 μl (2.76 mmol; 2 equiv.) of α-ethylbenzylamine is then added and the mixture is agitated at ambient temperature overnight. After evaporation of the dimethylformamide, the crude residue is purified by flash chromatography on silica gel (eluent: ethyl acetate/heptane 4:6) in order to produce a white solid (498 mg; yield of 65.5%). 
     NMR  1 H (DMSO-d 6 , 400 MHz)*: 9.00 (d, 1H, J=8.4 Hz); 7.36–7.30 (m, 4H); 7.25–7.21 (m, 1H); 6.72 (t, 1H, J=5.4 Hz); 6.67 (s, 1H); 6.63 (s, 1H); 6.53 (s, 2H); 4.77 (q, 1H, J=8.8 Hz); 3.95 (m, 2H); 2.84 (q, 2H, J=6 Hz); 2.21 (s, 6H); 1.74 (m, 2H); 151 (m, 2H); 1.36 (s, 9H); 1.31 (q, 2H, J=7.2 Hz); 1.13 (m, 2H); 0.89 (t, 3H, J=7.2 Hz). MS/LC: m/z=551.44 (M+H) + . 
     EXAMPLE 2826 
     (2Z)-3-(5-aminopentyl)-2-[(3,5-dimethylphenyl)imino]-N-(1-phenylpropyl)-2,3-dihydro-1,3-thiazole-4-carboxamide dihydrochloride 
     (C 26 H 34 N 4 OS.2HCl; MM=523.57) 
     
       
         
         
             
             
         
       
     
     300 mg (0.54 mmol) of tert-butyl 5-[(2Z)-2-[(3,5-dimethylphenyl)imino]-4-{[(1-phenylpropyl)amino]carbonyl}-1,3-thiazol-3(2H)-yl]pentylcarbamate is dissolved in 15 ml of ethyl acetate. After bubbling anhydrous hydrogen chloride through the reaction medium for one hour at ambient temperature, the corresponding dihydrochloride salt precipitates. It is recovered by filtration and washed with diethyl ether in order to produce a white solid (268 mg; yield of 94.8%). 
     NMR  1 H (DMSO-d 6 , 400 MHz)*: 9.48 (broad s, 1H); 8.03 (broad s, 3H); 7.39–7.32 (m, 5H); 7.25 (t, 1H, J=7.2 Hz); 7.00 (m, 3H); 4.80 (q, 1H, J=8.4 Hz); 4.33 (broad s, 2H); 2.70 (q, 2H, J=6.8 Hz); 2.29 (s, 6H); 1.77 (m, 2H); 1.65 (m, 2H); 1.52 (m, 2H); 1.27 (m, 2H); 0.89 (t, 3H, J=7.2 Hz). 
     MS/LC: m/z=451.35 (M+M) + . 
     According to method G, a series of compounds can be synthesized which include: 
     the R1 and R2 groups already described for method A; and 
     the R5 groups already described for method C. 
     In particular, the compounds shown in the table below have been synthesised using method G. 
                                                                                                Ex.   R1   R2   R5   Purity (%)   rt (min)   [M + H] +                 2827                                                                     69 + 27   4.57 + 4.73   477.33               2828                                                                     98   4.36   437.29               2829                                                                     98   4.37   437.33               2830                                                                     98   3.72   423.37               2831                                                                     99   3.73   423.37               2832                                                                     99   4.07   455.32               2833                                                                     99   4.29   471.32               2834                                                                     98   4.33   515.24               2835                                                                     99   3.87   451.34               2836                                                                     99   3.88   451.34                    
Pharmacological Properties of the Products of the Invention
 
     The compounds of the present invention can and have been tested as regards their affinity for different sub-types of somatostatin receptors according to the procedures described below. 
     Study of the Affinity for the Sub-Types of Human Somatostatin Receptors: 
     The affinity of a compound of the invention on sub-types of human somatostatin receptors 1 to 5 (sst 1 , sst 2 , sst 3 , sst 4  and sst 5 , respectively) is determined by measurement of the inhibition of the bond of [ 125 I-Tyr 11 ]SRIF-14 to transfected CHO-K1 cells. 
     The gene of the sst 1  receptor of human somatostatin was cloned in the form of a genomic fragment. A segment PstI-XmnI of 1.5 Kb containing 100 bp of the non transcribed 5′ region, 1.17 Kb of the coding region in totality, and 230 bp of the non transcribed 3′ region is modified by the addition of the linker BglII. The resulting DNA fragment is subcloned in the BamHI site of a pCMV-81 in order to produce the expression plasmid in mammals (provided by Dr. Graeme Bell, Univ. Chicago). A cloned cell line expressing in a stable fashion the sst 1  receptor is obtained by transfection in CHO-K1 cells (ATCC) using the calcium phosphate co-precipitation method. The plasmid pRSV-neo (ATCC) is included as selection marker. Cloned cell lines were selected in an RPMI 1640 medium containing 0.5 mg/ml of G418 (Gibco), followed by circular cloning and multiplication in culture. 
     The gene of the sst 2  receptor of human somatostatin, isolated in the form of a genomic fragment of DNA of 1.7 Kb BamHI-HindIII and subcloned in a plasmid vector pGEM3Z (Promega), was provided by Dr. G. Bell (Univ. of Chicago). The expression vector of the mammalian cells is constructed by inserting the BamHI-HindII fragment of 1.7 Kb in endonuclease restriction sites compatible with the plasmid pCMV5. A cloned cell line is obtained by transfection in CHO-K1 cells using the calcium phosphate co-precipitation method. The plasmid pRSV-neo is included as selection marker. 
     The sst 3  receptor is isolated as a genomic fragment, and the complete coding sequence is contained in a BamHI/HindIII fragment of 2.4 Kb. The expression plasmid in mammals, pCMV-h3, is constructed by insertion of the NcoI-HindIII fragment of 2.0 Kb in the EcoRI site of the vector pCMV after modification of the terminations and addition of EcoRI linkers. A cloned cell line expressing in a stable fashion the sst 3  receptor is obtained by transfection in CHO-K1 cells (ATCC) by the calcium phosphate co-precipitation method. The plasmid pRSV-neo (ATCC) is included as selection marker. Cloned cell lines were selected in an RPMI 1640 medium containing 0.5 mg/ml of G418 (Gibco), followed by circular cloning and multiplication in culture. 
     The expression plasmid of the human sst 4  receptor, pCMV-HX, was provided by Dr. Graeme Bell (Univ. Chicago). This vector contains the genomic fragment coding for the human sst 4  receptor of 1.4 Kb NheI—NheI, 456 bp of the non transcribed 5′ region, and 200 bp of the non transcribed 3′ region, cloned in the XbaI/EcoRI sites of PCMV-HX. A cloned cell line expressing in a stable fashion the sst 4  receptor is obtained by transfection in CHO-K1 (ATCC) cells by the calcium phosphate co-precipitation method. The plasmid pRSV-neo (ATCC) is included as selection marker. Cloned cell lines were selected in an RPMI. 1640 medium containing 0.5 mg/ml of G418 (Gibco), followed by circular cloning and multiplication in culture. 
     The gene corresponding to the human sst 5  receptor, obtained by the PCR method using a genomic λ clone as probe was provided by Dr. Graeme Bell (Univ. Chicago). The resulting PCR fragment of 1.2 Kb contains 21 base pairs of the non transcribe 5′ region, the coding region in totality, and 55 bp of the non transcribed 3′ region. The clone is inserted in an EcoRI site of the plasmid pBSSK(+). The insert is recovered in the form of a HindIII-XbaI fragment of 1.2 Kb for subcloning in an expression vector in mammals, pCVM5. A cloned cell line expressing in a stable fashion the sst 5  receptor is obtained by transfection in CHO-K1 cells (ATCC) by the calcium phosphate co-precipitation method. The plasmid pRSV-neo (ATCC) is included as selection marker. Cloned cell lines were selected in an RPMI 1640 medium containing 0.5 mg/ml of G418 (Gibco), followed by circular cloning and multiplication in culture. 
     The CHO-K1 cells which express in a stable fashion the human sst receptors are cultured in an RPMI 1640 medium containing 10% of foetal calf serum and 0.4 mg/ml of geneticin. The cells are collected with EDTA at 0.5 mM and centrifuged at 500 g for approximately 5 minutes at approximately 4° C. The pellet is resuspended in a Tris 50 mM buffer at pH 7.4 and centrifuged twice at 500 g for approximately 5 minutes at approximately 4° C. The cells are lysed by sonication then centrifuged at 39000 g for approximately 10 minutes at 4° C. The pellet is resuspended in the same buffer and centrifuged at 50000 g for approximately 10 minutes at approximately 4° C. and the membranes in the pellet obtained are stored at −80° C. 
     The competitive inhibition experiments of the bond with [ 125 I-Tyr 11 ]SRIF-14 are carried out in duplicate in 96-well polypropylene plates. The cell membranes (10 μg protein/well) are incubated with [ 125 I-Tyr 11 ]SRIF-14 (0.05 nM) for approximately 60 min. at approximately 37° C. in a HEPES 50 mM buffer (pH 7.4) containing BSA 0.2%, MgCl 2  5 mM, Trasylol &#39;200 KIU/ml, bacitricin 0.02 mg/ml and phenylmethylsulphonyl fluoride 0.02 mg/ml. 
     The bound [ 125 I-Tyr 11 ]SRIF-14 is separated from the free [ 125 -Tyr 11 ]SRIF-14 by immediate filtration, through GF/C glass fibre filter plates (Unifilter, Packard) pre-impregnated with 0.1% of polyethylenimine (P.E.I.), using a Filternate 196 (Packard). The filters are washed with 50 mM HEPES buffer at approximately 0–4° C. for approximately 4 seconds and their radioactivity is determined using a counter (Packard Top Count). 
     The specific bond is obtained by subtracting the non-specific bond (determined in the presence of 0.1 μM of SRIF-14) from the total bond. The data relative to the bond is analyzed by computer-aided non-linear regression analysis (MDL) and the values of the inhibition constants (Ki) are determined. 
     Determination of the agonist or antagonist character of a compound of the present invention is carried out using the test described below. 
     Functional Test: Inhibition of Production of Intracellular cAMP: 
     CHO-K1 cells expressing the sub-types of human somatostatin receptors (SRIF-14) are cultured in 24-well plates in an RPMI 1640 medium with 10% of foetal calf serum and 0.4 mg/ml of geneticin. The medium is changed the day preceding the experiment. 
     The cells at a rate of 10 5  cells/well are washed twice with 0.5 ml of new RPMI medium comprising 0.2% BSA completed by 0.5 mM of 3-isobutyl-1-methylxanthine (IBMX) and incubated for approximately 5 minutes at approximately 37° C. 
     The production of cyclic AMP is stimulated by the addition of 1 mM of forskolin (ASK) for 15–30 minutes at approximately 37° C., 
     The inhibitory effect of the somatostatin of an agonist compound is measured by the simultaneous addition of FSK (1 μM), SRIF-14 (10 −12  M to 10 −6  M) and of the compound to be tested (10 −10  M to 10 −5  M). 
     The antagonist effect of a compound is measured by the simultaneous addition of FSK (1 μM), SRIF-14 (1 to 10 mM) and of the compound to be tested (10 −10  M to 10 −5  M). 
     The reaction medium is eliminated and 200 ml of 0.1 N HCl is added. The quantity of cAMP is measured by a radioimmunological test (FlashPlate SMP001A kit, New England Nuclear). 
     RESULTS  
     The tests carried out according to the protocols described above have demonstrated that the products of general formula (I) defined in the present Application have a good affinity for at least one of the sub-types of somatostatin receptors, the inhibition constant K i  being lower than micromolar for certain exemplified compounds, and in particular for the products shown in the table below. 
     
       
         
           
               
               
             
               
                   
               
               
                   
                 K i   
               
               
                 Formula of compound 
                 (nM) 
               
               
                   
               
             
            
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 &lt;200 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 &lt;200 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 &lt;200 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 &lt;200 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 &lt;200 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 &lt;200 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 &lt;200 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 &lt;200 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
               
               
                   
               
               
                 
                   
                     
                     
                         
                         
                     
                   
                 
                 &lt;200 
               
               
                   
               
            
           
         
       
     
     In addition to the compounds in the above tables, each of the compounds of Examples 2827 to 2836 also has a K, constant lower than 200 nM.