Patent Publication Number: US-4927834-A

Title: 1,2-diamino compounds, processes for their preparation and pharmaceutical compositions containing them

Description:
The present invention is concerned with new 1,2-diamino compounds, processes for the preparation thereof and pharmaceutical compositions containing them. 
     The new 1,2-diamino compounds according to the present invention are compounds of the general formula: ##STR2## wherein R 1  is a straight-chained or branched C 1  -C 12  -alkyl radical which can be substituted by a phenyl, naphthyl or C 3  -C 7  -cycloalkyl radical, or is a straight-chained or branched C 2  -C 6  -alkenyl radical which can be substituted by a C 3  -C 7  -cycloalkyl radical or by a phenyl or naphthyl radical, or is a C 3  -C 7  -cycloalkyl radical or a mono- or bicyclic aromatic radical which is unsubtituted or substituted one or more times, in which the substituents can be C 1  -C 4  -alkyl, C 1  -C 4  -alkoxy, carboxyl or carbethoxy, R 2  and R 3 , which can be the same or different, are straight-chained or branched, saturated or unsaturated C 1  -C 6  -alkyl radicals which can optionally be substituted by hydroxyl, C 1  -C 3  -alkoxy or C 1  -C 3  -alkoxy-C 1  -C 3  -alkoxy, or together with the nitrogen atom to which they are attached, form a saturated or unsaturated ring which can contain further heteroatoms and is optionally substituted by a lower alkyl radical, a lower alkoxy radical or an oxygen atom, A is a valency bond or a straight-chained or branched alkylene radical containing up to 6 and preferably up to 3 carbon atoms, R 4  is a mono- or bicyclic aromatic or heteroaromatic radical which is unsubstituted or substituted one or more times, in which the substituents are alkyl, C 2  -C 6  -alkenyl, alkoxy, C 2  -C 6  -alkenyloxy, hydroxyalkyl, C 2  -C 6  -alkylenedioxy, hydroxyalkoxy, alkoxyalkoxy, alkylamino, dialkylamino, alkoxycarbonylalkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylsulphonyloxy, carboxyl, alkoxycarbonyl, aminocarbonyl, mono- or dialkylaminocarbonyl, haloalkyl or cyano groups, as well as halogen atoms, such as chlorine, bromine or fluorine, X is a valency bond or a straight-chained or branched, saturated or unsaturated hydrocarbon radical containing up to 6 carbon atoms, Y is a valency bond or an oxygen atom and R 5  is a C 3  -C 7  -cycloalkyl radical or a mono- or bicyclic aromatic or heteroaromatic radical which is unsubstituted or substituted one or more times, in which the substituents are alkyl, alkoxy, C 2  -C 6  -alkenyloxy, aralkoxy, hydroxyl, hydroxyalkoxy, alkoxyalkoxy, alkoxycarbonylalkoxy, C 1  -C 2  -alkylenedioxy, dialkylamino, alkylthio, alkylsulphinyl, alkylsulphonyl, alkylsulphonyloxy, hydroxyalkyl, carboxyl, alkoxycarbonyl, aminocarbonyl, mono-or dialkylaminocarbonyl or cyano, as well as halogen atoms, such as chlorine, bromine or fluorine, with the proviso that Y is not an oxygen atom when X is a valency bond and when R 1  is a saturated hydrocarbon X must be a radical containing at least 2 carbon atoms, and the pharmacologically acceptable salts thereof. 
     The C 1  -C 12  -alkyl radical R 1  is preferably methyl, ethyl, propyl, isopropyl, isobutyl, isoamyl, isohexyl, n-hexyl, n-octyl or n-dodecyl and especially isobutyl, isoamyl or isohexyl. As a rule, the C 3  -C 7  -cycloalkyl radical is cyclopentyl or cyclohexyl. When the alkyl radical is substituted, then the cycloalkylmethyl, benzyl and phenethyl radicals are preferred. Preferred C 2  -C 6  -alkenyl radicals are allyl, methallyl and isopentenyl. A substituted radical can be styryl or cinnamyl. Mono- and bicyclic aromatic radicals R 1 , R 4  and R 5  are preferably phenyl, naphthyl, indanyl, indenyl and tetralinyl. 
     R 2  and R 3  preferably signify methyl, ethyl, propyl, allyl or methallyl. Rings which R 2  and R 3  can form together with the nitrogen atom to which they are attached are preferably pyrrolidine or piperidine rings and especially the pyrrolidine ring. The heteroatoms which the rings can contain are nitrogen, sulphur and oxygen. These include rings such as piperazine, morpholine and thiomorpholine. Substituents of the above-mentioned rings are especially C 1  -C 3  -alkyl and C 1  -C 3  -alkoxy radicals, for example methyl, ethyl, propyl, methoxy, ethoxy and propoxy. As a rule, the oxygen substituent, together with the carbon atom to which it is attached, represents a carbonyl group. Corresponding rings are, for example, the pyrrolidinone and piperidinone rings. 
     Heteroaromatic radicals R 4  and R 5  are preferably pyridyl, pyrimidinyl, pyrazinyl, thienyl, oxazolyl, pyrazolyl, imidazolyl, tetrazolyl, thiazolyl, iso-oxazolyl quinolyl, isoquinolyl, benzofuranyl, benzothienyl, benzothiazolyl, indolyl and furanyl and especially benzofuranyl, pyridyl, furanyl and thienyl. 
     The alkyl radicals, alone or in combination with other radicals of substituents R 4  and R 5  of the ring systems contain up to 6 and preferably up to 4 carbon atoms and are especially methyl radicals. The substitution can be single or multiple. 
     The compounds of general formula (I) according to the present invention can be prepared in known manner in that 
     (a) a compound of the general formula: ##STR3## in which R 1 , R 2  and R 3  have the above-given meanings, is reacted with a compound of the general formula: ##STR4## in which A, X, Y, R 4  and R 5  have the above-given meanings; or 
     (b) a compound of the general formula: ##STR5## in which R 1 , R 2  and R 3  have the above-given meanings, is reacted with a compound of general formula (III); or 
     (c) a compound of the general formula: ##STR6## in which R 1 , R 2  and R 3  have the above-given meanings and B is a halogen atom or an alkoxy radical, is subjected to an amide formation reaction with a compound of general formula (III) and the compound obtained of general formula: ##STR7## in which R 1 , R 2 , R 3 , R 4 , R 5 , A, X and Y have the above-given meanings, is reduced with a complex hydride or diborane. 
     The reaction of a compound of general formula (II) with a compound of general formula (III) to give a compound of general formula (I) according to the present invention takes place in known manner in an inert solvent, for example toluene, xylene or dimethylformamide, at a temperature of from 40° C. and the reflux temperature of the solvent in the presence of an alkaline condensation agent, for example sodium hydride or sodamide. 
     The compounds of general formula (II) can be prepared by reacting a compound of the general formula: 
     
         R.sub.1 OH                                                 (VII) 
    
     in which R 1  has the above-given meaning, with epichlorohydrin in the presence of aqueous sodium hydroxide solution and of a phase transfer catalyst, for example tetrabutylammonium bromide, and the compound obtained of the general formula: ##STR8## in which R 1  has the above-given meaning, is reacted with an amine of the general formula: 
     
         R.sub.2 --NH--R.sub.3                                      (IX) 
    
     in which R 2  and R 3  have the above-given meanings and the compound obtained of the general formula: ##STR9## in which R 1 , R 2  and R 3  have the above-given meanings, is reacted with thionyl chloride in an inert solvent to give a compound of general formula (II). 
     The reaction of a compound of general formula (IV) with a compound of general formula (III) to give a compound of general formula (I) according to the present invention takes place in an inert solvent, for example toluene or xylene, at a temperature of from 40° C. to the reflux temperature of the solvent in the presence of an alkaline condensation agent, for example sodium hydride or sodamide. 
     The compounds of general formula (IV) can be prepared by reducing a compound of the general formula: ##STR10## in which R 1 , R 2  and R 3  have the above-given meanings and R is an alkyl radical, with a complex hydride, for example lithium aluminum hydride, in an inert solvent in known manner to give a compound of the general formula: ##STR11## in which R 1 , R 2  and R 3  have the above-given meanings and reacting this in an inert solvent with thionyl chloride to give a compound of general formula (IV). 
     The starting compounds of general formula (XI) can be prepared according to the process described in Federal Republic of Germany Patent Specification No. 28 02 864. 
     The reaction of a compound of general formula (V) with a compound of general formula (III) to give a compound of general formula (VI), as well as the reduction of this compound to a compound of general formula (I) according to the present invention, takes place according to processes known from the literature. 
     The compounds of general formula (V), in which B is a halogen atom, can be prepared by hydrolysing a compound of general formula (XI) and reacting the compound obtained of the general formula: ##STR12## in which R 1 , R 2  and R 3  have the above-given meanings, with a halogenation agent, for example thionyl chloride, in an inert solvent. 
     The compounds of general formula (III) can be prepared in that, with maintenance of the above-given definitions for A, X, Y, R 4  and R 5   
     (a) a compound of the general formula: 
     
         R.sub.4 A--NH.sub.2 
    
     is reacted with a compound of the general formula: 
     
         R.sub.5 --Y--COCl 
    
     and the amide obtained of the general formula: 
     
         R.sub.4 --A--NH--CO--Y--R.sub.5 
    
     is reduced with a complex hydride or diborane; or 
     (β) a compound of the general formula: 
     
         R.sub.4 --A&#39;--CO--Cl 
    
     in which A&#39; is an alkyl radical with up to 5 and preferably 1 or 2 carbon atoms, is reacted with a compound of the general formula: 
     
         R.sub.5 --Y--X--NH.sub.2 
    
     and the amide obtained of the general formula: 
     
         R.sub.4 --A&#39;--CO--NH--X--Y--R.sub.5 
    
     is reduced with a complex hydride or diborane; or 
     (γ) by reductive amination of a carbonyl compound of the general formula: 
     
         R.sub.5 --Y--X&#39;--CO--Z 
    
     in which Z is a hydrogen atom or an alkyl radical and X&#39; is a saturated or unsaturated, straight-chained or branched alkyl radical, X&#39; always having one carbon atom less than X, with an amine of the general formula: 
     
         R.sub.4 ANH.sub.2 
    
     or 
     (δ) by reductive amination of a compound of the general formula: 
     
         R.sub.4 A&#39;--CO--V 
    
     in which V is a hydrogen atom or an alkyl radical and A&#39; is a saturated or unsaturated, straight-chained or branched alkyl radical, A&#39; always having one carbon atom less than A, with a compound of the general formula: 
     
         R.sub.5 YX--NH.sub.2 
    
     The compounds of general formula (I) according to the present invention possess an asymmetric carbon atom. Therefore, the present invention also includes racemates and the optically-active forms of the compounds of general formula (I) according to the present invention, as well as processes for the preparation thereof. 
     The optically-active compounds can be prepared from their racemic mixtures by known methods via diastereomeric salts. For the racemate resolution there can be used, for example, tartaric acid, malic acid, camphoric acid, camphorsulphonic acid or dibenzoyltartaric acid. 
     For the conversion of the compounds of general formula (I) into their pharmacologically acceptable salts, these are reacted, preferably in an organic solvent, with the equivalent amount of an inorganic or organic acid, for example hydrochloric acid, hydrobromic acid, phosphoric acid, sulphuric acid, acetic acid, salicylic acid, citric acid, benzoic acid, naphthoic acid, o-acetoxybenzoic acid, adipic acid, maleic acid, oxalic acid, fumaric acid or cyclamic acid. 
     The compounds of general formula (I) according to the present invention possess valuable pharmacological properties. They are characterised especially by a blood vessel-relaxing action and can, therefore, be used for the therapy of heart-circulatory diseases. 
     The new compounds of general formula (I) according to the present invention and the salts thereof can be administered enterally or parenterally in liquid or solid form. As injection medium it is preferred to use water which contains the additives usual in the case of injection solutions, such as stabilising agents, solubilising agents or buffers. Such additives include, for example, tartrate and citrate buffers, ethanol, complex formers (such as ethylenediamine-tetraacetic acid and its non-toxic salts) and high molecular weight polymers (such as liquid polyethylene oxide) for viscosity regulation. Solid carrier materials include, for example, starch, lactose, mannitol, methyl cellulose, talc, highly dispersed silicic acids, high molecular weight fatty acids (such as stearic acid), gelatine, agar-agar, calcium phosphate, magnesium stearate, animal and vegetable fats and solid high molecular weight polymers (such as polyethylene glycols). Compositions suitable for oral administration can, if desired, contain flavouring and sweetening agents. 
     Besides the compounds described in the following Examples, the following compounds are also especially preferred. 
     
         __________________________________________________________________________
 ##STR13##                                                                
R.sub.1     R.sub.2, R.sub.3 R.sub.4    R.sub.5       A X    Y            
__________________________________________________________________________
 ##STR14##                                                                
             ##STR15##                                                    
                              ##STR16##                                   
                                         ##STR17##    --                  
                                                        CH.sub.2          
                                                             --           
 ##STR18##                                                                
             ##STR19##                                                    
                              ##STR20##                                   
                                         ##STR21##    --                  
                                                        CH.sub.2          
                                                             --           
 ##STR22##                                                                
             ##STR23##                                                    
                              ##STR24##                                   
                                         ##STR25##    --                  
                                                        CH.sub.2          
                                                             --           
 ##STR26##                                                                
             ##STR27##                                                    
                              ##STR28##                                   
                                         ##STR29##    --                  
                                                        CH.sub.2          
                                                             --           
 ##STR30##                                                                
             ##STR31##                                                    
                              ##STR32##                                   
                                         ##STR33##    --                  
                                                        CH.sub.2          
                                                             --           
 ##STR34##                                                                
             ##STR35##                                                    
                              ##STR36##                                   
                                         ##STR37##    --                  
                                                        CH.sub.2          
                                                             --           
 ##STR38##                                                                
             ##STR39##                                                    
                              ##STR40##                                   
                                         ##STR41##    --                  
                                                        CH.sub.2          
                                                             --           
 ##STR42##                                                                
             ##STR43##                                                    
                              ##STR44##                                   
                                         ##STR45##    --                  
                                                        CH.sub.2          
                                                             --           
 ##STR46##                                                                
             ##STR47##                                                    
                              ##STR48##                                   
                                         ##STR49##    --                  
                                                        CH.sub.2          
                                                             --           
 ##STR50##                                                                
             ##STR51##                                                    
                              ##STR52##                                   
                                         ##STR53##    --                  
                                                        CH.sub.2          
                                                             --           
 ##STR54##                                                                
             ##STR55##                                                    
                              ##STR56##                                   
                                         ##STR57##    --                  
                                                        CH.sub.2          
                                                             --           
 ##STR58##                                                                
             ##STR59##                                                    
                              ##STR60##                                   
                                         ##STR61##    --                  
                                                        CH.sub.2          
                                                             --           
 ##STR62##                                                                
             ##STR63##                                                    
                              ##STR64##                                   
                                         ##STR65##    --                  
                                                        CH.sub.2          
                                                             --           
 ##STR66##                                                                
             ##STR67##                                                    
                              ##STR68##                                   
                                         ##STR69##    --                  
                                                        CH.sub.2          
                                                             --           
 ##STR70##                                                                
             ##STR71##                                                    
                              ##STR72##                                   
                                         ##STR73##    --                  
                                                        CH.sub.2          
                                                             --           
 ##STR74##                                                                
             ##STR75##                                                    
                              ##STR76##                                   
                                         ##STR77##    --                  
                                                        CH.sub.2          
                                                             --           
 ##STR78##                                                                
             ##STR79##                                                    
                              ##STR80##                                   
                                         ##STR81##    --                  
                                                        CH.sub.2          
                                                             --           
 ##STR82##                                                                
             ##STR83##                                                    
                              ##STR84##                                   
                                         ##STR85##    --                  
                                                        CH.sub.2          
                                                             --           
__________________________________________________________________________
 
    
    
    
     The following Examples are given for the purpose of illustrating the present invention: 
     Example 1. 
     2-(N-Pyrrolidino)-3-isobutoxy-N-phenyl-N-(2-phenyl-ethyl-propylamine oxalate. 
     6.3 g. N-phenyl-N-(2-phenylethyl)-amine, together with 7.7 g. 2-chloro-1-isobutoxy-3-(N-pyrrolidino)-propane are dissolved in 50 ml. anhydrous toluene. 5.8 g. Sodium hydride (50% oily suspension) are added thereto and the mixture is heated under reflux for 2 hours. It is then cooled, the mixture is poured on to water and the organic phase is separated off. The aqueous phase is extracted again with toluene. The combined organic phases are washed with water, dried over anhydrous sodium sulphate and evaporated. The residue is purified by chromatography on a silica gel column (elution agent methylene chloride/2% methanol). 
     The appropriate column fractions are evaporated. The residue is dissolved in ethyl acetate and the solution mixed with a solution of oxalic acid in ethyl acetate. The precipitate is filtered off and again recrystallised from ethyl acetate. There are obtained 2.1 g. 2-(N-pyrrolidino)-3-isobutoxy-N-phenyl-N-(2-phenylethyl)-propylamine oxalate; m.p. 95°-96° C. 
     The halo compounds of general formula (II) required as starting materials are prepared analogously to 2-chloro-1-allyloxy-3-N-pyrrolidinopropane, the preparation of which is described in the following by way of example: 
     A mixture of 50 g. allyl alcohol, 160 ml. concentrated aqueous sodium hydroxide solution, 230 g. epichlorohydrin and 2 g. tetrabutylammonium bromide is stirred for 3 hours at 45° C. The mixture is then diluted with water and extracted with ethyl acetate. The organic phase is washed with water, dried over anhydrous sodium sulphate and evaporated. The residue is distilled in a vacuum to give 67 g. 3-allyloxy-1,2-epoxypropane; b.p. 78° C./56 mm.Hg. This is dissolved in 80 ml. ethanol and mixed dropwise, while stirring, with a solution of 86 ml. pyrrolidine in 80 ml. ethanol. After completion of the addition, stirring is continued for 1 hour at 70° C., the mixture is evaporated and the residue is distilled in a vacuum to give 70 g. 2-hydroxy-1-allyloxy-3-N-pyrrolidinopropane; b.p. 75° C./10 -2  mm Hg. 
     60 g. 2-Hydroxy-1-allyloxy-3-N-pyrrolidinopropane are dissolved in 120 ml. dichloroethane and the solution mixed dropwise, while stirring, with 26 ml. thionyl chloride. After completion of the addition, stirring is continued for 2 hours at 70° C., the mixture is cooled, mixed with water, the pH value is adjusted with aqueous sodium hydroxide solution to 10 and the organic phase is separated off. This is dried over anhydrous sodium sulphate and evaporated. The residue is purified by column chromatography to give 44 g. 2-chloro-1-allyloxy-3-N-pyrrolidinopropane as an oily product. 
     The following compounds are prepared in an analogous way: 
     
           ##STR86##
  No. R.sub.1 R.sub.2, R.sub.3 R.sub.4 R.sub.5 A X Y
            2 (CH.sub.3).sub.2CHCH.sub.2
  ##STR87##
  ##STR88##
  ##STR89##
  -- (CH.sub.2).sub.2 -- Oxalate 95-96° C. ethyl acetate  3
 (CH.sub.3).sub.2CHCH.sub.2
  ##STR90##
  ##STR91##
  ##STR92##
  -- (CH.sub.2).sub.2 -- Fumarate 103-104° C. ethyl acetate  4
 (CH.sub.3).sub.2CHCH.sub.2
  ##STR93##
  ##STR94##
  ##STR95##
  -- (CH.sub.2).sub.2 -- Oxalate 147-148° C. ethyl acetate  5
 (CH.sub.3).sub.2CHCH.sub.2
  ##STR96##
  ##STR97##
  ##STR98##
  -- (CH.sub.2).sub.2 -- Oxalate 134° C. ethyl acetate
  6 (CH.sub.3).sub.2CHCH.sub.2
  ##STR99##
  ##STR100##
  ##STR101##
  -- (CH.sub.2).sub.2 O Fumarate 94-96° C. ethyl acetate  7
 (CH.sub.3).sub.2CHCH.sub.2
  ##STR102##
  ##STR103##
  ##STR104##
  -- (CH.sub.2).sub.2 O Fumarate 134° C. ethyl acetate
  8 (CH.sub.3).sub.2CHCH.sub.2
  ##STR105##
  ##STR106##
  ##STR107##
  -- (CH.sub.2).sub.3 -- Oxalate 96-97° C. ethyl acetate  9
 (CH.sub.3).sub.2CHCH.sub.2
  ##STR108##
  ##STR109##
  ##STR110##
  -- (CH.sub.2).sub.3 -- Oxalate 112-113° C. ethyl acetate  10
 (CH.sub.3).sub.2CHCH.sub.2
  ##STR111##
  ##STR112##
  ##STR113##
  -- (CH.sub.2).sub.2 -- Oxalate 95-96° C. ethyl acetate  11
 (CH.sub.3).sub.2CHCH.sub.2
  ##STR114##
  ##STR115##
  ##STR116##
  -- (CH.sub.2).sub.2 -- oil m/e 380  12 (CH.sub.3).sub.2CHCH.sub.2
  ##STR117##
  ##STR118##
  ##STR119##
  CH.sub.2 (CH.sub.2).sub.2 -- oil m/e 394  13 (CH.sub.3).sub.2CHCH.sub.2
  ##STR120##
  ##STR121##
  ##STR122##
  -- (CH.sub.2).sub.2 -- oil m/e 425
  14 CH.sub.2CHCH.sub.2
 ##STR123##
  ##STR124##
  ##STR125##
  -- CH.sub.2 -- Oxalate 152-153° C. ethyl acetate
  15
 ##STR126##
  ##STR127##
  ##STR128##
  ##STR129##
  -- CH.sub.2 -- Oxalate 159-161° C. Isopropanol
  16
 ##STR130##
  ##STR131##
  ##STR132##
  ##STR133##
  -- CH.sub.2 -- Oxalate 128-130° C. ethyl acetate
  17
 ##STR134##
  ##STR135##
  ##STR136##
  ##STR137##
  -- CH.sub.2 --  Oxalate 152° C. ethyl acetate
  18
 ##STR138##
  ##STR139##
  ##STR140##
  ##STR141##
  -- CH.sub.2 -- oil m/e 407
  19
 ##STR142##
  ##STR143##
  ##STR144##
  ##STR145##
  -- CH.sub.2 -- oil m/e 420
  20
 ##STR146##
  ##STR147##
  ##STR148##
  ##STR149##
  -- CH.sub.2 -- oil m/e 436
  21
 ##STR150##
  ##STR151##
  ##STR152##
  ##STR153##
  -- CH.sub.2 -- 159°  C. ethyl acetate
  22
 ##STR154##
  ##STR155##
  ##STR156##
  ##STR157##
  -- CH.sub.2 -- oil m/e 394
  23
 ##STR158##
  ##STR159##
  ##STR160##
  ##STR161##
  -- CH.sub.2 -- oil m/e 407
  24
 ##STR162##
  ##STR163##
  ##STR164##
  ##STR165##
  -- CH.sub.2 -- Oxalate 125-126° C. ethyl acetate
  25
 ##STR166##
  ##STR167##
  ##STR168##
  ##STR169##
  -- CH.sub.2 -- Oxalate 114-115°  C. ethyl acetate
  26
 ##STR170##
  ##STR171##
  ##STR172##
  ##STR173##
  -- CH.sub.2 -- oil m/e 442
  27
 ##STR174##
  ##STR175##
  ##STR176##
  ##STR177##
  -- CH.sub.2 -- Oxalate 173-174° C. ethyl acetate
  28
 ##STR178##
  ##STR179##
  ##STR180##
  ##STR181##
  -- CH.sub.2 -- Oxalate 192-193° C. ethyl acetate
  29
 ##STR182##
  ##STR183##
  ##STR184##
  ##STR185##
  -- CH.sub.2 -- oil m/e 424
  30
 ##STR186##
  ##STR187##
  ##STR188##
  ##STR189##
  -- CH.sub.2 -- oil m/e 408
  31
 ##STR190##
  ##STR191##
  ##STR192##
  ##STR193##
  -- CH.sub.2 -- Oxalate 135-136° C. Isopropanol
  32
 ##STR194##
  ##STR195##
  ##STR196##
  ##STR197##
  -- CH.sub.2 -- oil m/e 426
  33
 ##STR198##
  ##STR199##
  ##STR200##
  ##STR201##
  -- CH.sub.2 -- oil m/e 411
   34
 ##STR202##
  ##STR203##
  ##STR204##
  ##STR205##
  -- CH.sub.2 -- Oxalate 128-130° C. ethyl acetate
  35
 ##STR206##
  ##STR207##
  ##STR208##
  ##STR209##
  -- CH.sub.2 -- oil m/e 382
  36
 ##STR210##
  ##STR211##
  ##STR212##
  ##STR213##
  -- CH.sub.2 -- oil m/e 398
  37
 ##STR214##
  ##STR215##
  ##STR216##
  ##STR217##
  -- CH.sub.2 -- oil m/e 408
  38
 ##STR218##
  ##STR219##
  ##STR220##
  ##STR221##
  -- CH.sub.2 -- oil m/e 378
  39
 ##STR222##
  ##STR223##
  ##STR224##
  ##STR225##
  -- CH.sub.2 -- oil m/e 410
  40
 ##STR226##
  ##STR227##
  ##STR228##
  ##STR229##
  -- CH.sub.2 -- oil m/e 436
  41
 ##STR230##
  ##STR231##
  ##STR232##
  ##STR233##
  -- CH.sub.2 -- oil m/e 408
  42
 ##STR234##
  ##STR235##
  ##STR236##
  ##STR237##
  -- CH.sub.2 -- oil m/e 394
  43
 ##STR238##
  ##STR239##
  ##STR240##
  ##STR241##
  -- -- -- oil m/e 390
  44
 ##STR242##
  ##STR243##
  ##STR244##
  ##STR245##
  -- -- -- oil m/e 402
  45
 ##STR246##
  ##STR247##
  ##STR248##
  ##STR249##
  -- CH.sub.2 -- Oxalate 130-131° C. ethyl acetate
  46
 ##STR250##
  ##STR251##
  ##STR252##
  ##STR253##
  -- CH.sub.2 -- Oxalate 135-136°  C. ethyl acetate
  47
 ##STR254##
  ##STR255##
  ##STR256##
  ##STR257##
  -- (CH.sub.2).sub.2 -- Oxalate 79° C. ethyl acetate
  48
 ##STR258##
  ##STR259##
  ##STR260##
  ##STR261##
  -- (CH.sub.2).sub.2 -- Oxalate 125-126° C. ethyl acetate  49
  ##STR262##
  ##STR263##
  ##STR264##
  ##STR265##
  -- (CH.sub.2).sub.3 -- Fumarate 127° C. ethyl acetate  50
  ##STR266##
  ##STR267##
  ##STR268##
  ##STR269##
  -- (CH.sub.2).sub.2 O Oxalate 118-119° C. ethyl acetate   51
  ##STR270##
  ##STR271##
  ##STR272##
  ##STR273##
  -- (CH.sub.2).sub.3 -- Oxalate 130-131° C. ethyl acetate  52
  ##STR274##
  ##STR275##
  ##STR276##
  ##STR277##
  -- CH.sub.2 -- oil m/e 365
  53
 ##STR278##
  ##STR279##
  ##STR280##
  ##STR281##
  -- CH.sub.2 -- oil m/e 368
  54
 ##STR282##
  ##STR283##
  ##STR284##
  ##STR285##
  -- CH.sub.2 -- oil m/e 424
  55
 ##STR286##
  ##STR287##
  ##STR288##
  ##STR289##
  -- (CH.sub.2).sub.2 O Oxalate 118-120° C.
  56
 ##STR290##
  ##STR291##
  ##STR292##
  ##STR293##
  -- CH.sub.2 -- oil m/e 424
  57
 ##STR294##
  ##STR295##
  ##STR296##
  ##STR297##
  -- (CH.sub.2).sub.2 -- Oxalate 97-98° C. ethyl acetate  58
  ##STR298##
  ##STR299##
  ##STR300##
  ##STR301##
  -- (CH.sub.2).sub.2 O Oxalate 93-95° C. ethyl acetate  59
  ##STR302##
  ##STR303##
  ##STR304##
  ##STR305##
  -- (CH.sub.2).sub.3 -- oil m/e 452
  60
 ##STR306##
  ##STR307##
  ##STR308##
  ##STR309##
  -- (CH.sub.2).sub.4 -- Oxalate 92-95° C.
  61
 ##STR310##
  ##STR311##
  ##STR312##
  ##STR313##
  CH.sub.2 CH.sub.2 -- oil m/e 408
  62
 ##STR314##
  ##STR315##
  ##STR316##
  ##STR317##
  CH.sub.2 CH.sub.2 -- oil m/e 413
  63
 ##STR318##
  ##STR319##
  ##STR320##
  ##STR321##
  -- CH.sub.2 -- oil m/e 424
  64
 ##STR322##
  ##STR323##
  ##STR324##
  ##STR325##
  -- CH.sub.2 -- oil m/e 380
  65
 ##STR326##
  ##STR327##
  ##STR328##
  ##STR329##
  -- CH.sub.2 -- oil m/e 378
  66
 ##STR330##
  C.sub.2 H.sub.5C.sub.2
  H.sub.5
 ##STR331##
  ##STR332##
  -- CH.sub.2 -- Oxalate 61-63° C. ethyl acetate
  67
 ##STR333##
  ##STR334##
  ##STR335##
  ##STR336##
  -- CH.sub.2 -- Oxalate 149-150° C. ethyl acetate
  68
 ##STR337##
  ##STR338##
  ##STR339##
  ##STR340##
  CH.sub.2 CH.sub.2 -- oil m/e 438
  69
 ##STR341##
  ##STR342##
  ##STR343##
  ##STR344##
  -- CH.sub.2 -- Oxalate 151-152° C. ethyl acetate
  70
 ##STR345##
  ##STR346##
  ##STR347##
  ##STR348##
  -- CH.sub.2 -- oil m/e 378
  71 (CH.sub.3).sub.2CHCH.sub.2
 ##STR349##
  ##STR350##
  ##STR351##
  --  CHCHCH.sub.2 -- Oxalate 119-120° C. ethyl acetate  72
 (CH.sub.3).sub.2CHCH.sub.2
  ##STR352##
  ##STR353##
  ##STR354##
  --
  ##STR355##
  -- oil m/e 380
  73
 ##STR356##
  ##STR357##
  ##STR358##
  ##STR359##
  -- CH.sub.2 -- Oxalate 136-137° C. ethyl acetate
  74
 ##STR360##
  ##STR361##
  ##STR362##
  ##STR363##
  -- CH.sub.2 -- oil m/e 416
  75
 ##STR364##
  ##STR365##
  ##STR366##
  ##STR367##
  -- CH.sub.2 -- oil m/e 421
  76
 ##STR368##
  ##STR369##
  ##STR370##
  ##STR371##
  -- (CH.sub.2).sub.2 -- oil m/e 430  77 (CH.sub.3).sub.2CHCH.sub.2
  ##STR372##
  ##STR373##
  ##STR374##
  -- (CH.sub.2).sub.2 -- oil m/e 440  78 (CH.sub.3).sub.2CHCH.sub.2
  ##STR375##
  ##STR376##
  ##STR377##
  -- (CH.sub.2).sub.2 O oil m/e 456  79 (CH.sub.3).sub.2CHCH.sub.2
  ##STR378##
  ##STR379##
  ##STR380##
  -- (CH.sub.2).sub.4 -- oil m/e 408  80 (CH.sub.3).sub.2CHCH.sub.2
  ##STR381##
  ##STR382##
  ##STR383##
  -- CH.sub.2 -- oil m/e 411
  81
 ##STR384##
  ##STR385##
  ##STR386##
  ##STR387##
  -- CH.sub.2 -- Fumarate 137-138° C. ethyl acetate
  82
 ##STR388##
  ##STR389##
  ##STR390##
  ##STR391##
  -- CH.sub.2 -- oil m/e 364
  83
 ##STR392##
  ##STR393##
  ##STR394##
  ##STR395##
  -- CH.sub.2 -- Oxalate 133-135° C. ethyl acetate
  84
 ##STR396##
  ##STR397##
  ##STR398##
  ##STR399##
  -- -- -- Oxalate 105° C. ethyl acetate
  85
 ##STR400##
  ##STR401##
  ##STR402##
  ##STR403##
  -- CH.sub.2 -- Oxalate 118° C. ethyl acetate
  86
 ##STR404##
  ##STR405##
  ##STR406##
  ##STR407##
  -- -- -- Oxalate 120° C. ethyl acetate
  87
 ##STR408##
  ##STR409##
  ##STR410##
  ##STR411##
  -- CH.sub.2 -- Oxalate 108° C. ethyl acetate
  88
 ##STR412##
  ##STR413##
  ##STR414##
  ##STR415##
  -- CH.sub.2 -- Oxalate 99° C. ethyl acetate
  89
 ##STR416##
  ##STR417##
  ##STR418##
  ##STR419##
  -- (CH.sub.2).sub.2 -- Fumarate 105° C. ethyl acetate  90
  ##STR420##
  ##STR421##
  ##STR422##
  ##STR423##
  -- -- -- Oxalate 104° C. ethyl acetate
  91
 ##STR424##
  ##STR425##
  ##STR426##
  ##STR427##
  -- CH.sub.2 -- oil m/e 408
  92
 ##STR428##
  ##STR429##
  ##STR430##
  ##STR431##
  -- CH.sub.2 -- Fumarate 148° C. ethyl acetate
  93
 ##STR432##
  ##STR433##
  ##STR434##
  ##STR435##
  -- CH.sub.2 -- oil m/e 384
  94
 ##STR436##
  ##STR437##
  ##STR438##
  ##STR439##
  -- -- -- Oxalate 135° C. ethyl acetate
  95
 ##STR440##
  ##STR441##
  ##STR442##
  ##STR443##
  -- CH.sub.2 -- oil m/e 438
  96
 ##STR444##
  ##STR445##
  ##STR446##
  ##STR447##
  -- CH.sub.2 -- oil m/e 438
  97
 ##STR448##
  ##STR449##
  ##STR450##
  ##STR451##
  -- CH.sub.2 -- oil m/e 452
  98
 ##STR452##
  ##STR453##
  ##STR454##
  ##STR455##
  -- CH.sub.2 -- Fumarate 101° C. ethyl acetate
  99
 ##STR456##
  ##STR457##
  ##STR458##
  ##STR459##
  -- CH.sub.2 -- oil m/e 424
  100
 ##STR460##
  ##STR461##
  ##STR462##
  ##STR463##
  -- CH.sub.2 -- oil m/e 408
  101
 ##STR464##
  ##STR465##
  ##STR466##
  ##STR467##
  -- CH.sub.2 -- oil m/e 422
  102
 ##STR468##
  ##STR469##
  ##STR470##
  ##STR471##
  -- CH.sub.2 -- oil m/e 422
  103
 ##STR472##
  ##STR473##
  ##STR474##
  ##STR475##
  -- CH.sub.2 -- Oxalate 128° C. ethyl acetate
  104
 ##STR476##
  ##STR477##
  ##STR478##
  ##STR479##
  -- CH.sub.2 -- Oxalate 103°
  C. ethyl acetate
 
    
     In Vitro Test Results 
     Rat aorta segments were suspended in an organ bath and connected to a force pickup, and stretched to 15 mN. The KrebsHenseleit solution in the organ bath had the following composition: 
     NaCl=118 mM; KCl=4.7 mM; MgSO 4  =1.2 mM; CaCl 2  =2.5 mM; KH 2  PO 4  =1.2 mM; NaHCO 3  =25 mM; glucose -11 mM. 
     The aorta segments were left in the bath for 45 minutes to reach equilibrium, and then a stock solution of KCl was added to the organ bath to increase the KCl concentration of the nutrient solution in the organ bath to 40 mM. After the aorta segments had been exposed for 30 minutes to the increased potassium concentration, the test substances were added at an identical concentration, (10 -6  mol/liter) to the bath solution. The test substances produced a relaxation effect which varied with the different test substances, and is reported in Table 1 below as a percent of the pre-contraction, determined 25 minutes after the test substance addition to the bath solution. The percent relaxation reported is a measure of the Ca++ antagonistic effect of the respective test substances. The higher the percent relaxation value reported in the right-hand column of Table 1, the more active the substance. 
     
                       TABLE 1                                                     
______________________________________                                    
% relaxation following pre-contraction with 40 mM K+ ions                 
Incubation time: 25 minutes                                               
Concentration of the test compound: 10.sup.-6 M/liter                     
Number of tested preparations per substance: n = 4                        
Example No.     % relaxation                                              
______________________________________                                    
Bepridil (control)                                                        
                51                                                        
54              79                                                        
56              72                                                        
63              67                                                        
67              58                                                        
69              68                                                        
24              71                                                        
70              82                                                        
34              76                                                        
57              69                                                        
______________________________________                                    
 Bepridil =                                                               
 β-[2Methylpropoxy)methyl]-N-phenyl-N-(phenylmethyl)-1-pyrro--       
 lidineethanamine.                                                        
 
    
     As will be appreciated from Table 1, the compounds of the present invention are cardiovascular agents exhibiting antianginal and antiarrhythemic properties. 
     The compounds of the present invention may be administered to patients in a suitable amount, generally in an amount of 50 to 1000 mg per dose. The patient will normally be administered from 1 to 3 doses daily. The total daily dosage to the patient will typically be in the range of 1 to 40 mg/kg.