Patent Publication Number: US-2009220956-A1

Title: Prediction of Local Recurrence of Breast Cancer

Description:
FIELD OF THE INVENTION 
     The invention relates to the field of medicine, in particular to cancer, more specifically breast cancer, most specifically to a method to predict the local recurrence of breast cancer after breast conserving therapy. 
     INTRODUCTION AND STATE OF THE ART 
     Breast cancer is the leading cause of death in women and its occurrence has been gradually increasing in the western world over the last 30 years. Several types of therapy exist nowadays, of which removal of the tumor tissue is the most prominent, which removal can be as radical as complete mastectomy, with or without the adjacent lymph nodes. Also radiotherapy is applied in most cases (after mastectomy radiotherapy is applied in selected cases primarily based on tumor size, presence of angioinvasion and lymph node status), either alone (only in very advanced tumors surgery is omitted) or in combination with surgical removal of the tumor tissue. Nowadays, mostly for esthetical reasons it is tried to achieve as much as possible breast conserving therapy, i.e. preventing a total mastectomy by precise surgery of the tumor tissue and precise radiotherapeutical treatment of the remaining surrounding tissue (entire breast; always) and lymph nodes (selectively) either or not in combination with chemotherapy. 
     Breast conserving therapy is defined as excision of the primary tumor and a tumor free margin, followed by radiation therapy (XRT) of the whole breast or the breast and regional lymph nodes. If chemotherapy is not to be given, XRT should be started in a timely fashion after conservative surgery is performed (usually within 2 to 4 weeks). XRT may be delayed if significant seroma is present, if a mastitis is present, if aim range of motion is still limited, or if incisions are not healed. The best way to integrate XRT and chemotherapy in patients who are to receive both is not yet well defined. The two modalities have been given concurrently, sequentially, or in a sandwich fashion (i.e., chemotherapy both prior to and after XRT). Often all or a portion of chemotherapy is given initially. 
     Megavoltage radiation therapy is recommended to the whole breast using tangential fields (without bolus) treating to a dose of 50 Gy (1.8 to 2 Gy per fiaction) over a 4½ to 5½ week period. This is usually followed by a boost of XRT to the area of the excisional biopsy for an additional 10 to 26 Gy. Omission of the boost may be associated with an increased risk of breast cancer recurrence, even in patients with negative margins and especially in patients below the age of 40. 
     Regional (lymph node) radiotherapy is sometimes performed after breast conserving surgery including a level I/level II axillary lymph node dissection. Regional radiotherapy is controversial but frequently considered for patients with positive axillary lymph nodes (&gt;3), a positive high axillary lymph node, extranodal disease extension (doubtful), or a large axillary lymph node; or if &lt;6 lymph nodes were removed from the axilla without the aid of sentinel lymph node biopsy. When done, regional XRT may include the supraclavicular, axillary, and internal mammary chain areas. 
     However, still between 10% aid 40% of women with operable breast cancer will experience an isolated locoregional recurrence following their primary treatment. There is currently no good evidence that adjuvant systemic treatment is effective in this situation and there is no standard treatment for women who have such a recurrence. After breast conserving therapy, treatment of a local recurrence often results in a so-called “salvage mastectomy”, optionally followed by radiotherapy or hyperthermia. If a local recurrence is combined with a general relapse by metastases the treatment will be determined on a case-by-case basis, but will in any case comprise hormonal or chemotherapy. 
     Radiotherapy regimens are, dependent on the characteristics of the primary tumor, able to produce two-thirds reduction in local recurrence and without long-term hazard, would be expected to produce an absolute increase in 20-year survival of about 2-4% (except for women at particularly low risk of local recurrence). 
     Breast cancer is a complex disease. Accumulation and combination of genetic and epigenetics anomalies cause tumorogenesis, genetic instability and acquisition of an increasingly invasive and resistant phenotype. This combinatorial origin and the heterogeneity of malignant cells, and the variety of the host background, create molecularly distinct subgroups of tumors endowed with different responses to therapy and clinical outcome. One of these factors is the recurrence of breast tumors after breast conserving therapy. 
     Conventional biological techniques have so far successfully identified some mechanisms of oncogenesis and indicated altered key genes such as ERBB2, P53, BRCA1 and BRCA2. Today, however, the elucidation of the human genome and technological developments have made it possible to simultaneously analyze the activity of many, if not all, genes in biological samples. Among the merging technologies, DNA (cDNA or oligo) arrays are currently prominent. DNA arrays tackle the complex and combinatorial nature of breast cancer genetics and offer an opportunity to confront the tumor heterogeneity. Key genes have been discovered by comparing the gene expression profiles of different (groups of) patients of normal and carcinomic tissues. Some of the differentially expressed genes are known to be involved in mammary oncogenesis (e.g. ERBB2 and MUC1). For others, such as GATA3, the correlation is unexpected and calls for further investigation (Bertucci, F. et al., Hum. Mol. Genet. (2000), 9:2981-2991). 
     Comprehensive gene expression profiles can be used to discriminate new relevant subclasses (see Perou, C. M. et al., (2000) Nature 406:747-752, and Sorlie, T. et al. (2001) Proc. Natl. Acad. Sci. USA 98:10869-10874) within classes of clinically indistinguishable tumors. Such stratification, together with the increasing availability of new alternative diagnostic and therapeutic options, is expected to guide the clinicians in choosing the most appropriate therapeutic strategy. Two examples which have emerged can be given here. 
     Bertucci et al. (supra) have been able by analyzing the expression of about 200 genes to identify 2 groups with different survival from a cohort of patients having a tumor with poor prognosis treated with chemotherapy (anthracyclin). They were able to identify 23 genes which were differentially expressed, and can now predict which patients from the cohort would benefit from anthracyclin chemotherapy. 
     Secondly, Van&#39;t Veer et al. (Nature (2002) 415:530-536, and WO 2004/065545) found a set of 70 genes (among an array of about 25,000 genes) which could distinguish between patients with or without 5 years metastasis-free survival, thereby preventing secondary or overlong treatments for patients without need for them. This profile has been validated by Van de Vijver et al (NEJM 2002) on a series of 295 patients, both lymph node negative and positive. 
     Recently, it has been demonstrated (Chang, H. Y., et al. (2004) PLoS Biol. 2(2):e7, to be found at: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=314300) that a similar distinction could be made on another set of genes which relate to wound healing. However, of this set of 512 genes only 11 genes were in common with the set of Van&#39;t Veer. 
     All these profile focus on predicting distant metastasis free and/or overall survival. 
     Yet, there is still a need for a distinction between groups of breast cancer patients which have undergone breast conserving therapy with respect to the breast tumor recurrence chance (so called local recurrence). 
     SUMMARY OF THE INVENTION 
     This invention now provides a method to predict the risk of local recurrence of breast cancer in patients having received breast conserving therapy comprising the steps of 
     a. measuring a wound signature gene expression profile of a patient; and
 
b. classifying said profile as “activated” or “quiescent”, wherein a classification as “activated” indicates a high risk on local recurrence. Preferably in such a method the wound signature expression profile comprises the expression profile of at least about 60%, preferably about 70%, more preferably about 80%, more preferably about 90%, more preferably about 95%, more preferably about 99%, most preferably all of the 442 genetic elements listed in Table 1. Alternatively, the wound signature expression profile comprises at least the expression profile of the top 200, preferably the top 250, more preferably the top 300, more preferably the top 350, more preferably the top 400, more preferably the top 425, more preferably the top 440 of the 442 genetic elements listed in Table 1.
 
     Another aspect of the invention is the use of a wound signature gene set for the determination of the risk on local recurrence in breast cancer patients treated with breast conserving therapy, wherein preferably the wound signature gene set comprises at least about 60%, preferably about 70%, more preferably about 80%, more preferably about 90%, more preferably about 95%, more preferably about 99%, most preferably all of the 442 genetic elements listed in Table 1, or, alternatively comprises at least the top 200, preferably the top 250, more preferably the top 300, more preferably the top 350, more preferably the top 400, more preferably the top 425, more preferably the top 440 of the 442 genetic elements listed in Table 1 
    
    
     
       DESCRIPTION OF THE FIGURES 
         FIG. 1  shows the local recurrence free survival (according to Kaplan-Meier) for a group of breast cancer patients, which have been classified according to the method of the invention. The x-axis represents the number of years, while the y-axis represents the percentage (divided by 100) of patients. 
     
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     Chang et al. (supra) described the identification of a wound healing gene signature (identified in their publication as fibroblast core serum response (CSR) signature). This signature has been derived from wound healing tissue from normal fibroblasts. It was shown by Chang and co-workers that the molecular features that define the wound-type phenotype can predict an increased risk of metastasis and death in breast and other carcinomas. It appeared that patients with a so-called “activated Wound Signature” have a relatively poor outcome. 
     Now, surprisingly, it is shown by the present inventors that the wound signature genes, can also be used to predict an increased risk of local recurrence in breast tumors. 
     “Local recurrence” or “recurrence” as used in this specification means the outgrow of new or therapy resistent tumor cells on or from the spot of the first, treated tumor. It is different from metastasis, since metastasis normally requires spreading—e.g. through circulation or lymph tissue—of tumor cells which can trigger de novo tumor formation, while local recurrence does not require spread. 
     “Wound signature genes” or “wound healing signature genes” as used herein means the set of genes identified by Chang et al. (supra) and indicated by these authors also as CSR signature gene set. The set comprises 512 genes, which were present on the cDNA array used by Chang as 573 clones. Of these 512 genes 459 are uniquely identified in UniGene (http://www.ncbi.nlm.nih.gov/entrez/querv.fcgi?db=unigene). 
     As shown in the experimental data it surprisingly appeared possible to predict local recurrence on basis of the expression data of the Wound Signature genes. A local recurrence profile was developed on a randomly selected training set and tested on a validation set containing gene expression profiles of patients who remained free of local recurrence or who had had a local recurrence in the—median—7.8 years follow up period. 
     As indicated the Wound Signature gene set has been defined by Chang et al. (supra) according to their observation that wounds share many features with cancerous outgrowths. To come to their selection Chang et al. used a microarray of human cDNA containing approximately 43,000 elements, representing approximately 36,000 different genes. From a set of 50 fibroblast cultures derived from ten anatomic sites they identified the common serum response in fibroblasts by checking for high and low expressing genes, to find genes that were coordinately induced or repressed in transcriptional response to stimulation with serum. The thus obtained set was corrected by comparison with a set of genes periodically expressed during the HeLa cell cycle and skipping the overlapping clones. This resulted in a set of 512 genes (represented by 573 clones on the array). 
     In the present invention, an oligomicroarray as defined by van&#39;t Veer et al. (supra) was used. This set consisted of about 24,496 clones (Hu25K microarray) and is described on page 146-147 of WO 2004/065545, which description is herein incorporated by reference. It appeared that 442 clones of the wound signature gene set are present on this array. These are listed in Table 1. 
     To investigate a gene expression profile for these 442 clones, the array should be subjected to hybridisation with target polynucleotide molecules from a clinically relevant source, in this case e.g. a person with breast cancer having had breast conserving therapy. Therefore a fresh frozen (within 1 hour from surgical removal), liquid nitrogen (−80° C.) stored tumor sample needs to be available. Said target polynucleotide molecules should be expressed RNA or a nucleic acid derived thereform (e.g., cDNA or amplified RNA derived from cDNA that incorporates an RNA polymerase promoter). If the target molecules consist of RNA, it may be total cellular RNA, poly(A)+messenger RNA (mRNA) or fraction thereof, cytoplasmic mRNA, or RNA transcribed from cDNA (cRNA). Methods for preparaing total and poly(A)+messenger RNA are well known in the art, and are described e.g. in Sambrook et al., Molecular Cloning-A Laboratory Manual (2 nd  Ed.) Vols. 1-3, Cold Spring Harbor, N.Y. (1989). In one embodiment, RNA is extracted from cells using guanidinium thiocyanate lysis followed by CsCl centrifugation (Chrigwin et al., (1979) Biochem. 18:5294-5299). In another embodiment, total RNA is extracted using a silica-gel based column, commercially available examples of which include RNeasy (Qiagen, Valencia, Calif., USA) and SrataPrep (Stratagene, La Jolla, Calif., USA). Poly(A) +  messenger RNA can be selected, e.g. by selection with oligo-dT cellulose or, alternatively, by oligo-dT primed reverse transcription of total cellular RNA. In another embodiment, the polynucleotide molecules analyzed by the invention comprise cDNA, or PCR products of amplified RNA or cDNA. 
     The sample comprises breast cells from a normal individual (i.e., an individual not afflicted with breast tumor). Such a sample can be used for control hybridization experiments or to establish a baseline level. The sample may also be derived from collected samples from a number of normal individuals. In a preferred embodiment, the sample comprises breast cells from a person with breast cancer having had breast conserving therapy. In a further preferred embodiment, a collection of samples is used taken from a number of individuals having breast tumors. Said sample preferably comprises breast cancer cells, or cells that are suspected of being breast cancer cells. In yet another embodiment, the collection is derived from normal or breast cancer cell lines or cell line samples. If applicable, it is preferred that the percentage of tumor cells in a sample is more than 80%, more preferred more than 40%, more preferred more than 50%, more preferred more than 60%, more preferred more than 70%, more preferred more than 80%, more preferred more than 90%, or 100% of the total number of cells. 
     Preferably, the target polynucleotides are detectably labelled at one or more nucleotides, Any method known in the art may be used to detectably label the nucleotides. Preferably, this labelling incorporates the label uniformly along the length of the polynucleotide and is carried out at a high degree of efficiency. One embodiment for this labelling uses oligo-dT primed reverse transcription to incorporate the label; however, conventional methods hereof are biased toward generating 3′ end fragments. Thus, in a preferred embodiment, random primers (e.g. 9-mers) are used in reverse transcription to uniformly incorporate labelled nucleotides over the full length of the target polynucleotides. Alternatively, random primers may be used in conjunction with PCR methods or T7 promoter-based in vitro transcription methods in order to amplify the target polynucleotides. 
     In a preferred embodiment, the detectable label is a luminescent label. For example, fluorescent labels, bioluminescent labels, chemiluminescent labels and calorimetric labels may be used. In a highly preferred embodiment, the label is a fluorescent label, such as a fluorescein, a phosphor, a rhodamine, or a polymethine dye or derivative. In another embodiment, the detectable label is a radiolabelled nucleotide. 
     Nucleic acid hybridisation and wash conditions are chosen so that the target polynucleotide molecules specifically hybridize to the complementary polynucleotide sequences of the array, preferably to a specific array site, wherein its complementary DNA is located. Optimal hybridisation conditions will depend on the type (e.g., RNA or DNA) of the target nucleotides. General parameters for specific (i.e., stringent) conditions of hybridisation are described in Sambrook et al. (supra). Typical hybridisation conditions for cDNA microarrays are hybridisation in 5×SSC plus 0.2% SDS at 65 DC four hours, followed by washes at 25° C. in low stringency wash buffer (1×SSC plus 0.2% SDS), followed by 10 minutes at 25° C. in higher stringency wash buffer (0.1×SSC plus 0.2% SDS). 
     When fluorescently labelled probes are used, the fluorescence emissions at each site of the microarray may be detected by scanning confocal laser microscopy. In one embodiment, the arrays is scanned with a laser fluorescent scanner with a computer controlled X-Y stage and a microscope objective. Fluorescent laser scanning devices are described in e.g. Schena et al. (1996) Genome Res. 6:639-645. Signals are recorded and, in a preferred embodiment, analysed by computer using a 12 or 16 bit analog to digital board. In one embodiment the scanned image is despeckled using a graphics program (e.g., Hijaak Graphics Suite) and then analysed using an image gridding program that creates a spreadsheet of the average hybridisation at each wavelength at each site. 
     Using the above described general analysis method, the expression profile of the Wound Signature genes in a biological sample (e.g., a biopsy) can be assessed. Using a large group of patients Chang et al. found a biphasic distribution of expression profiles of the Wound Signature genes in breast cancer tumors, and they accordingly identified two groups of tumors: one with a so-called quiescent expression profile and the other with a so-called activated expression profile, wherein the activated profile was highly correlated with metastasis and poor overall survival. In the present invention we have now shown that an expression profile of the Wound Signature genes is highly correlated with local recurrence of breast tumors. 
     Therefore, the invention relates to a method to predict the risk of local recurrence of breast cancer tumors in patients having received breast conserving therapy comprising the steps of measuring a wound signature gene expression profile of a patient, and classifying said profile as “activated” or “quiescent”, wherein a classification as “activated” indicates a high risk on local recurrence. 
     The invention thus also relates to a method for determining a wound signature gene expression profile for local recurrence of breast cancer, comprising determining the expression profile of at least the top two hundred of the genes listed in Table 1 in a breast tumor sample from at least one patient with local recurrence; determining the expression profile from the genes in a breast tumor sample from at least one patient without local recurrence; and determining from said expression profiles an “activated” and/or a “quiescent” expression profile, wherein said activated profile is the average and/or mean of said at least one and preferably at least 4 and more preferably at least 9 or even more preferred at least 17 patients that showed local recurrence, and wherein said “quiescent” profile is the average and/or mean of said at least one and preferably at least 30, preferably at least 60, more preferably at least 81 and even more preferred 144 patients that did not show local recurrence. A test sample comprising cells from a subject for which the risk of local recurrence is to be determined is used to determine the test profile on the at least top 200 genes of table 1 whereupon the obtained test profile is classified as being from a patient with a high or a low risk by comparing said test profile with said “activated” and/or said “quiescent” profile. Preferably said test profile is compared with said “activated” profile. 
     For the comparison of the expression profiles, methods that are or will be known to a skilled person can be used, such as, but nor limited to, a Pearson correlation. 
     In a preferred embodiment, the method for determining the expression level from at least the top two hundred of the genes listed in Table 1 comprises the use of probes comprising nucleic acid sequences as listed in Table 1, or homologues thereof that are able to hybridize to the corresponding genes, such as homologues that are 80% or more, or 90% or more, identical to the nucleic acid sequences shown in Table 1. The probes may comprise DNA sequences, RNA sequences, or copolymer sequences of DNA and RNA The molecules may also comprise DNA and/or RNA analogues such as, for example nucleotide analogues or peptide nucleic acid molecules (PNA), or combinations thereof. The molecules may comprise full or partial fragments of genomic DNA. The molecules may also comprise synthesized nucleotide sequences, such as synthetic oligonucleotide sequences. The sequences can be synthesized enzymatically in vivo, or enzymatically in vitro (e.g. by PCR), or non-enzymatically in vitro. 
     Furthermore, the invention relates to a method for determining a wound signature gene expression profile for local recurrence of breast cancer, comprising hybridizing RNA or a derivative thereof obtained from a breast tumor sample to a set of nucleic acid molecules comprising probes for at least 200 of the genes listed in Table 1; and quantifying the hybridization signals obtained from the RNA or a derivative thereof to the probes. 
     The method for determining a wound signature gene expression profile for local recurrence of breast cancer may further comprise determining the mean expression value (centroid) for each of the hybridization signals to the probes. 
     In a further embodiment, the invention relates to a method for determining the risk for local recurrence in a breast tumor sample from a patient comprises determining a wound signature gene expression profile by hybridizing RNA or a derivative thereof obtained from a breast tumor sample from the patient with a set of nucleic acid molecules comprising probes for at least the top 200 of the genes listed in Table 1; comparing the profile with the profile obtained from a breast tumor sample with local recurrence; and determining from the comparison whether the patient is at high risk for local recurrence. 
     In a method for determining the risk for local recurrence, a Pearson correlation of the mean expression value can be used for comparing the profiles 
     Not all of the genes are evenly contributing to the discriminating effect. As is shown in Table 1, the genes differ in significant expression. Although the statistical data presented in the Example are calculated with all of the 442 genetic elements of Table 1, it is submitted that a good distinction between the two groups of patients and therewith a good predicting ability of the wound signature gene set can also be achieved with only a part of the elements of Table 1, Preferably 60% of the elements of Table 1 are included in the analysis, more preferably 70%, more preferably 80%, more preferably 90%, more preferably 95%, more preferably 99% and most preferably all of the elements. It would be advisable not to randomly choose the elements, but to pick the top 200, top 250, top 300, top 350, top 400, top 425, top 440 or all 442 elements listed in Table 1. Of course also other genetic elements which are linked to the fibroblast response to serum-stimulus may be included in the analysis. It is even predicted that such ‘novel’ elements, which have not been included in the present analysis because of the chance nature of the DNA arrays used, will have a significant expression which can rank at any place in Table 1. 
     Using the microalray as described in the Example (obtainable from Rosetta Inpharmatics LLC, Kirkland, US), together with the prescribed analysis method the risk of local recurrence of a tumor for any breast cancer patient treated with breast conservative therapy can be obtained. Calibration will generally be obtained by referring the gene expression profile of one patient to a control sample consisting of a pooled sample of a large number of breast cancer patients (see FIG. 2 of WO 2004/065545). After measuring the expression profile of the wound signature gene set, the Pearson correlation with respect to the centroid data of Table 1 has to be calculated. If this value is higher than the cut-off level (Pearson correlation value higher than 0.3233) the patient runs a high risk of local recurrence. 
     If another microarray than specified above is used, it is advisable to calibrate the profiling analysis by measuring a number of samples according to the method described above to establish the baseline level (i.e. the quiescent profile). This can easily be done by taking a sample from a non-tumerous and non-wound healing tissue. Such a ‘normal’ tissue should approximately give an expression profile which resembles the quiescent fibroblast state (see also  FIG. 2  of Chang et al.). The figures that are obtained can be compared to the figures presented by Chang et al., and/or the figures from the expression levels in Table 1, to have an indication of the differences caused by the analysis method. It will then be possible to calculate the Pearson correlation with respect to the centroid values of Table 1, and to see whether this value exceeds the threshold value of 0.3233. If a higher correlation is diagnosed, the patient will run an increased risk of local recurrence and therapy can be adjusted to cope with this prospect. Alternatively, or if the analysis measurements differ too much from the expression data presented in Table 1, a new centroid value should be calculated for those specific analysis conditions. For this a set of patients should be taken, with a known local recurrence, and the mean expression data for each gene from the wound signature gene set should be taken (see the Example for more details). Also, a new optimal cut-off value should then be established on the Pearson correlation data obtained with these new centroid values. 
     Example 
     In a previously described series of 295 stage I and II breast carcinomas treated at the Netherlands Cancer Institute (Van&#39;t Veer et al, supra; also page 164 ff of WO 2004/065545) gene expression data of about 25,000 genetic elements have been obtained using oligonucleotide microarray technology. 161 patients were treated with breast conserving therapy, of which 17 did show a local recurrence (LR) in the years that they were followed. The median follow-up was 7.8 years; the LR-free rate at 10 years for the entire group is 85% 
     The elements listed in Table 1 (wound signature genes) were identified on the microarray and an unsupervised hierarchical clustering (see Example 1 of WO 2004/066545) was used on the expression profiles for these genes to determine an activated or quiescent wound signature. 
     To further optimise the prognostic performance a training group (n=81 of which 9 LR) was defined and the expression profile of these patients was analysed. The mean expression value of the 9 LR patients was calculated for each gene (LR centroid value, see Table 1). Then for each of the 81 patients the Pearson correlation with the centroid value was calculated for the wound signature genes. A cut off value which would optimally discriminate between the two groups was determined (at Pearson correlation value=0.3233). This threshold was subsequently used to study risk of local recurrence in the validation set (n=80, 8 LR). Patients were classified as having an activated (high risk for local recurrence) or a quiescent (low risk for local recurrence) signature, based on a Pearson correlation value of above or below 0.3233, respectively. It appeared that the LR rate at 10 years in the validation series (see  FIG. 1  and Table 2) was 95% for the group classified as activated and 69.5% for the group classified as quiescent (p=0.0005).  FIG. 1  is a graphical representation of the local recurrence free survival score (according to Kaplan-Meier) for the validation series. The sensitivity in the validation set is 87.5% (⅞) with a specificity of 75% (54/72). Table 2 shows the data for the validation series from the Cox-regression model wherein the classifier (result from the Pearson correlation on the wound signature gene set) is weighted against known “historical” risk factors for a local recurrence. As shown the classifier is the only significant predictor for local recurrence (very low p-value (second column). The 3 rd  column indicates the hazard ratio or relative risk. So a patient with an activated (high risk for local recurrence) signature has a 23 fold risk at a local recurrence compared with a patient with a quiescent signature (low risk for local recurrence). The last 2 columns indicate the 95% Confidence interval. More details on the experimental procedure and the statistical analyses which can be used (e.g., Kaplan-Meier and Cox-regression analyses) can be found in WO 2004/065645 (whole text and specifically example 10). It thus appears that a wound signature gene set can be used to distinguish significantly in risk of LR after breast conserving therapy. 
     
       
         
           
               
               
             
               
                 TABLE 1 
               
               
                   
               
               
                 List of genes of the wound signature gene set. UniqID is the systemic name 
                   
               
               
                 of the sequence on the array. 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                   
                 SEQ 
                   
               
               
                   
                 Gene 
                   
                 Order_ 
                 Unigene_ 
                 Unigene_ 
                 ID 
               
               
                 UniqID 
                 Symbol 
                 Centroid 
                 Sig 
                 172_158 
                 158 
                 # 
               
               
                   
               
               
                 NM_001615 
                 ACTG2 
                 −0.5383953 
                 56 
                 Hs.403989 
                 Hs.378774 
                 1 
               
               
                   
               
               
                 NM_001647 
                 APOD 
                 −0.1826098 
                 57 
                 Hs.75736 
                 Hs.75736 
                 2 
               
               
                   
               
               
                 NM_004265 
                 FADSD6 
                 −0.2060959 
                 72 
                 Hs.388164 
                 Hs.184641 
                 3 
               
               
                   
               
               
                 NM_001710 
                 BF 
                 −0.2874178 
                 163 
                 Hs.69771 
                 Hs.69771 
                 4 
               
               
                   
               
               
                 NM_014585 
                 SLC11A3 
                 −0.1806041 
                 171 
                 Hs.409875 
                 Hs.5944 
                 5 
               
               
                   
               
               
                 NM_002345 
                 LUM 
                 −0.1596883 
                 300 
                 Hs.406475 
                 Hs.79914 
                 6 
               
               
                   
               
               
                 AL133644 
                   
                 −0.1037048 
                 311 
                 Hs.179735 
                 Hs.179735 
                 7 
               
               
                   
               
               
                 AF113007 
                 DKFZP586 
                 0.011318 
                 323 
                 Hs.288771 
                 Hs.288771 
                 8 
               
               
                   
                 AD522 
               
               
                   
               
               
                 NM_003878 
                 GGH 
                 0.1060228 
                 408 
                 Hs.78619 
                 Hs.78619 
                 9 
               
               
                   
               
               
                 Contig34896_RC 
                   
                 −0.0777164 
                 416 
                 Hs.8739 
                 Hs.170261 
                 10 
               
               
                   
               
               
                 D25328 
                 PFKP 
                 −0.2891304 
                 432 
                 Hs.26010 
                 Hs.99910 
                 11 
               
               
                   
               
               
                 NM_002318 
                 LOXL2 
                 −0.1697346 
                 516 
                 Hs.83354 
                 Hs.83354 
                 12 
               
               
                   
               
               
                 NM_020372 
                 LOC57100 
                 −0.1427509 
                 549 
                 Hs.373498 
                 Hs.373498 
                 13 
               
               
                   
               
               
                 AL137274 
                 MIG-6 
                 −0.0794952 
                 585 
                 Hs.11169 
                 Hs.11169 
                 14 
               
               
                   
               
               
                 Contig56705_RC 
                   
                 −0.0906733 
                 607 
                 Hs.380763 
                 Hs.60293 
                 15 
               
               
                   
               
               
                 Contig54295_RC 
                   
                 0.0499989 
                 630 
                 Hs.500350 
                 Hs.44829 
                 16 
               
               
                   
               
               
                 NM_000210 
                 ITGA6 
                 0.0304433 
                 632 
                 Hs.212296 
                 Hs.227730 
                 17 
               
               
                   
               
               
                 Contig57062_RC 
                   
                 −0.0168056 
                 676 
                 Hs.255149 
                 Hs.25253 
                 18 
               
               
                   
               
               
                 U95006 
                   
                 −0.0695112 
                 709 
                 Hs.37616 
                 Hs.37616 
                 19 
               
               
                   
               
               
                 NM_005063 
                 SCD 
                 −0.0116634 
                 736 
                 Hs.119597 
                 Hs.119597 
                 20 
               
               
                   
               
               
                 NM_006074 
                 STAF50 
                 0.0569467 
                 738 
                 Hs.318501 
                 Hs.318501 
                 21 
               
               
                   
               
               
                 NM_004585 
                 RARRE53 
                 −0.058851 
                 762 
                 Hs.17466 
                 Hs.17466 
                 22 
               
               
                   
               
               
                 NM_003129 
                 SQLE 
                 0.0171384 
                 826 
                 Hs.71465 
                 Hs.71465 
                 23 
               
               
                   
               
               
                 NM_016348 
                 C5ORF4 
                 −0.1066377 
                 841 
                 Hs.10235 
                 Hs.10235 
                 24 
               
               
                   
               
               
                 AL133074 
                   
                 −0.0381854 
                 845 
                 Hs.75497 
                 Hs.75497 
                 25 
               
               
                   
               
               
                 NM_000076 
                 CDKN1C 
                 0.0668578 
                 852 
                 Hs.106070 
                 Hs.106070 
                 26 
               
               
                   
               
               
                 NM_001993 
                 F3 
                 −0.2427101 
                 856 
                 Hs.62192 
                 Hs.62192 
                 27 
               
               
                   
               
               
                 NM_003379 
                 VIL2 
                 0.0300496 
                 895 
                 Hs.403997 
                 Hs.155191 
                 28 
               
               
                   
               
               
                 NM_000784 
                 CYP27A1 
                 −0.1121366 
                 911 
                 Hs.82568 
                 Hs.82568 
                 29 
               
               
                   
               
               
                 X59405 
                 MCP 
                 −0.0561621 
                 920 
                 Hs.83532 
                 Hs.83532 
                 30 
               
               
                   
               
               
                 M55914 
                 MPB1 
                 −0.0370872 
                 926 
                 # N/A 
                 Hs.254105 
                 31 
               
               
                   
               
               
                 NM_005694 
                 COX17 
                 −0.0719567 
                 976 
                 Hs.16297 
                 Hs.16297 
                 32 
               
               
                   
               
               
                 Contig47563_RC 
                   
                 0.1292021 
                 1005 
                 # N/A 
                 Hs.30818 
                 33 
               
               
                   
               
               
                 AB040884 
                 KIAA1451 
                 −0.0674023 
                 1034 
                 Hs.109694 
                 Hs.109694 
                 34 
               
               
                   
               
               
                 AF035284 
                   
                 −0.0321418 
                 0153 
                 Hs.503546 
                 Hs.132898 
                 35 
               
               
                   
               
               
                 NM_016423 
                 ZNF219 
                 −0.0716907 
                 1066 
                 Hs.250493 
                 Hs.250493 
                 36 
               
               
                   
               
               
                 NM_000484 
                 APP 
                 −0.0036143 
                 1080 
                 Hs.177486 
                 Hs.177486 
                 37 
               
               
                   
               
               
                 NM_001386 
                 DPYSL2 
                 0.0356441 
                 1083 
                 Hs.173381 
                 Hs.173381 
                 38 
               
               
                   
               
               
                 NM_003090 
                 SNRPA1 
                  8.69E−04 
                 1085 
                 Hs.434901 
                 Hs.80506 
                 39 
               
               
                   
               
               
                 NM_016058 
                 LOC51002 
                 −0.0520914 
                 1091 
                 Hs.157401 
                 Hs.433212 
                 40 
               
               
                   
               
               
                 NM_003255 
                 TIMP2 
                 −0.0888242 
                 1110 
                 Hs.6441 
                 Hs.6441 
                 41 
               
               
                   
               
               
                 NM_005648 
                 TCEB1 
                 −0.0206109 
                 1113 
                 Hs.435169 
                 Hs.184693 
                 42 
               
               
                   
               
               
                 AL050002 
                   
                 0.0040601 
                 1122 
                 Hs.357004 
                 Hs.94795 
                 43 
               
               
                   
               
               
                 NM_000214 
                 JAG1 
                 −9.07E−04 
                 1131 
                 Hs.409202 
                 Hs.91143 
                 44 
               
               
                   
               
               
                 AB029018 
                 KIAA1095 
                 −0.072232 
                 1146 
                 Hs.177635 
                 Hs.177635 
                 45 
               
               
                   
               
               
                 Contig37878_RC 
                   
                 0.0955788 
                 1179 
                 Hs.440973 
                 Hs.255416 
                 46 
               
               
                   
               
               
                 D43950 
                 KIAA0098 
                 0.0321762 
                 1231 
                 Hs.1600 
                 Hs.1600 
                 47 
               
               
                   
               
               
                 NM_000366 
                 TPM1 
                 −0.0160874 
                 1232 
                 Hs.133892 
                 Hs.77899 
                 48 
               
               
                   
               
               
                 NM_004126 
                 GNG11 
                 −0.0012581 
                 1235 
                 Hs.83381 
                 Hs.83381 
                 49 
               
               
                   
               
               
                 Contig2930_RC 
                 DAB2 
                 −0.0136946 
                 1247 
                 Hs.81988 
                 Hs.291804 
                 50 
               
               
                   
               
               
                 NM_000235 
                 LIPA 
                 0.0196271 
                 1258 
                 Hs.85226 
                 Hs.85226 
                 51 
               
               
                   
               
               
                 NM_001428 
                 ENO1 
                 −0.0117356 
                 1294 
                 Hs.433455 
                 Hs.254105 
                 52 
               
               
                   
               
               
                 NM_003670 
                 BHLHB2 
                 −0.1595493 
                 1298 
                 Hs.171825 
                 Hs.171825 
                 53 
               
               
                   
               
               
                 AK000060 
                 AK000060 
                 −0.1911419 
                 1311 
                 Hs.388877 
                 Hs.27973 
                 54 
               
               
                   
               
               
                 NM_003094 
                 SNRPE 
                 −0.0917718 
                 1323 
                 Hs.334612 
                 Hs.334612 
                 55 
               
               
                   
               
               
                 NM_002997 
                 SDC1 
                 −0.0861853 
                 1384 
                 Hs.82109 
                 Hs.82109 
                 56 
               
               
                   
               
               
                 NM_006813 
                 B4-2 
                 −0.0940814 
                 1390 
                 Hs.75969 
                 Hs.75969 
                 57 
               
               
                   
               
               
                 NM_012385 
                 P8 
                 −0.107813 
                 1417 
                 Hs.418692 
                 Hs.424279 
                 58 
               
               
                   
               
               
                 NM_002444 
                 MSN 
                 −0.0408763 
                 1478 
                 Hs.170328 
                 Hs.170328 
                 59 
               
               
                   
               
               
                 U82987 
                 BBC3 
                 −0.0864452 
                 1486 
                 Hs.87246 
                 Hs.87246 
                 60 
               
               
                   
               
               
                 AB007916 
                 FLJ13052 
                 0.0224214 
                 1488 
                 Hs.458492 
                 Hs.214646 
                 61 
               
               
                   
               
               
                 NM_003289 
                 TPM2 
                 −0.0545574 
                 1524 
                 Hs.300722 
                 Hs.300772 
                 62 
               
               
                   
               
               
                 NM_004911 
                 ERP70 
                 −0.051383 
                 1545 
                 Hs.93659 
                 Hs.93659 
                 63 
               
               
                   
               
               
                 NM_000877 
                 IL1R1 
                 −0.0408296 
                 1575 
                 Hs.82112 
                 Hs.82112 
                 64 
               
               
                   
               
               
                 NM_006519 
                 TCTEL1 
                 0.0062432 
                 1591 
                 Hs.266940 
                 Hs.266940 
                 65 
               
               
                   
               
               
                 Contig57494_RC 
                   
                 −0.0364058 
                 1620 
                 Hs.406339 
                 Hs.289069 
                 66 
               
               
                   
               
               
                 NM_000269 
                 NME1 
                 0.1873206 
                 1624 
                 Hs.118638 
                 Hs.118638 
                 67 
               
               
                   
               
               
                 NM_018048 
                 FLJ10292 
                 −0.0022011 
                 1637 
                 Hs.104650 
                 Hs.104650 
                 68 
               
               
                   
               
               
                 Contig3607_RC 
                   
                 −0.1111468 
                 1650 
                 # N/A 
                 Hs.31297 
                 69 
               
               
                   
               
               
                 NM_006022 
                 TSC22 
                 0.0097983 
                 1669 
                 Hs.114360 
                 Hs.114360 
                 70 
               
               
                   
               
               
                 Contig3820_RC 
                 LOC56898 
                 −0.1493656 
                 1684 
                 Hs.124696 
                 Hs.124696 
                 71 
               
               
                   
               
               
                 Contig3695_RC 
                   
                 0.0152393 
                 1760 
                 Hs.26670 
                 Hs.26670 
                 72 
               
               
                   
               
               
                 NM_003186 
                 TAGLN 
                 −0.101256 
                 1772 
                 Hs.410977 
                 Hs.433399 
                 73 
               
               
                   
               
               
                 Contig48249_RC 
                   
                 −0.033877 
                 1795 
                 Hs.386784 
                 Hs.8768 
                 74 
               
               
                   
               
               
                 AK001362 
                   
                 −0.0041243 
                 1833 
                 Hs.173374 
                 Hs.173374 
                 75 
               
               
                   
               
               
                 NM_000222 
                 KIT 
                 −0.0978341 
                 1918 
                 Hs.81665 
                 Hs.81665 
                 76 
               
               
                   
               
               
                 NM_004107 
                 FCGRT 
                 −0.0915406 
                 1932 
                 Hs.111903 
                 Hs.111903 
                 77 
               
               
                   
               
               
                 NM_018455 
                 BM039 
                 −0.002616 
                 1945 
                 Hs.283532 
                 Hs.283532 
                 78 
               
               
                   
               
               
                 AL049471 
                   
                 0.0479844 
                 1956 
                 Hs.12702 
                 Hs.12702 
                 79 
               
               
                   
               
               
                 NM_000177 
                 GSN 
                 0.0159066 
                 1974 
                 Hs.446537 
                 Hs.290070 
                 80 
               
               
                   
               
               
                 NM_001948 
                 DUT 
                 −0.0863181 
                 1982 
                 Hs.367676 
                 Hs.367676 
                 81 
               
               
                   
               
               
                 S90469 
                 POR 
                 −0.0056894 
                 2038 
                 Hs.354056 
                 Hs.167246 
                 82 
               
               
                   
               
               
                 NM_014463 
                 LSM3 
                 −0.0528273 
                 2117 
                 Hs.111632 
                 Hs.111632 
                 83 
               
               
                   
               
               
                 NM_016824 
                 ADD3 
                 0.1132136 
                 2124 
                 Hs.324470 
                 Hs.324470 
                 84 
               
               
                   
               
               
                 NM_002106 
                 H2AFZ 
                 0.0111531 
                 2154 
                 Hs.119192 
                 Hs.119192 
                 85 
               
               
                   
               
               
                 Contig52945_RC 
                   
                 0.0872467 
                 2244 
                 Hs.172792 
                 Hs.172792 
                 86 
               
               
                   
               
               
                 NM_001070 
                 TUBG1 
                 −0.0609361 
                 2253 
                 Hs.21635 
                 Hs.21635 
                 87 
               
               
                   
               
               
                 NM_006807 
                 CBX1 
                 0.0275433 
                 2307 
                 Hs.77254 
                 Hs.77254 
                 88 
               
               
                   
               
               
                 NM_002950 
                 RPN1 
                 0.0069991 
                 2389 
                 Hs.2280 
                 Hs.2280 
                 89 
               
               
                   
               
               
                 NM_002792 
                 PSMA7 
                 0.038883 
                 2429 
                 Hs.233952 
                 Hs.233952 
                 90 
               
               
                   
               
               
                 NM_004595 
                 SMS 
                 0.0183218 
                 2433 
                 Hs.449032 
                 Hs.89718 
                 91 
               
               
                   
               
               
                 NM_006745 
                 SC4MOL 
                 −0.0046231 
                 2439 
                 Hs.393239 
                 Hs.239926 
                 92 
               
               
                   
               
               
                 Contig1998_RC 
                   
                 0.0184363 
                 2458 
                 Hs.24758 
                 Hs.24758 
                 93 
               
               
                   
               
               
                 NM_002816 
                 PSMD12 
                 0.1177832 
                 2525 
                 Hs.4295 
                 Hs.4295 
                 94 
               
               
                   
               
               
                 NM_006291 
                 TNFAIP2 
                 −0.0699154 
                 2533 
                 Hs.101382 
                 Hs.101382 
                 95 
               
               
                   
               
               
                 NM_005962 
                 MXI1 
                 −0.0582266 
                 2594 
                 Hs.118630 
                 Hs.118630 
                 96 
               
               
                   
               
               
                 AF052159 
                   
                 0.0228531 
                 2614 
                 Hs.5957 
                 Hs.5957 
                 97 
               
               
                   
               
               
                 NM_012412 
                 PURB 
                 −0.0055242 
                 2642 
                 Hs.301005 
                 Hs.301005 
                 98 
               
               
                   
               
               
                 NM_016951 
                 HSPC224 
                 0.0606148 
                 2646 
                 Hs.15159 
                 Hs.15159 
                 99 
               
               
                   
               
               
                 NM_018639 
                 LOC55884 
                 0.0719628 
                 2649 
                 Hs.459470 
                 Hs.136644 
                 100 
               
               
                   
               
               
                 NM_002166 
                 ID2 
                 0.0289007 
                 2684 
                 Hs.180919 
                 Hs.180919 
                 101 
               
               
                   
               
               
                 NM_006114 
                 D1951177E 
                 −0.0092836 
                 2694 
                 Hs.310542 
                 Hs.30928 
                 102 
               
               
                   
               
               
                 Contig58471_RC 
                   
                 −0.0827957 
                 2726 
                 Hs.363138 
                 Hs.17567 
                 103 
               
               
                   
               
               
                 NM_004457 
                 FACL3 
                 0.0088717 
                 2741 
                 Hs.268012 
                 Hs.268012 
                 104 
               
               
                   
               
               
                 AK002174 
                 LOC51088 
                 −0.0255738 
                 2764 
                 Hs.272251 
                 Hs.272239 
                 105 
               
               
                   
               
               
                 Contig2652_RC 
                   
                 −0.0273396 
                 2770 
                 Hs.436617 
                 Hs.184164 
                 106 
               
               
                   
               
               
                 Contig56768_RC 
                 SLC5A3 
                 0.0527617 
                 2830 
                 Hs.268016 
                 Hs.268016 
                 107 
               
               
                   
               
               
                 NM_007043 
                 HRB2 
                 −0.0465499 
                 2854 
                 Hs.269857 
                 Hs.154762 
                 108 
               
               
                   
               
               
                 AF052100 
                   
                 −0.0306271 
                 2868 
                 Hs.6651 
                 Hs.6651 
                 109 
               
               
                   
               
               
                 NM_000791 
                 DHFR 
                 0.0658927 
                 2887 
                 Hs.83765 
                 Hs.83765 
                 110 
               
               
                   
               
               
                 NM_001424 
                 EMP2 
                 −0.0693488 
                 2893 
                 Hs.531561 
                 Hs.29191 
                 111 
               
               
                   
               
               
                 U47101 
                 NIFU 
                 0.0124747 
                 2919 
                 Hs.350702 
                 Hs.9908 
                 112 
               
               
                   
               
               
                 Contig4574_RC 
                   
                 −0.0165929 
                 2928 
                 Hs.111099 
                 Hs.111099 
                 113 
               
               
                   
               
               
                 NM_014018 
                 HSPC007 
                 −0.0420779 
                 2960 
                 Hs.55097 
                 Hs.55097 
                 114 
               
               
                   
               
               
                 Contig1505_RC 
                   
                 −0.0468072 
                 2979 
                 Hs.8345 
                 Hs.39504 
                 115 
               
               
                   
               
               
                 Contig45316_RC 
                   
                 −0.0159842 
                 2985 
                 Hs.5957 
                 Hs.5957 
                 116 
               
               
                   
               
               
                 NM_018281 
                 FLJ10948 
                 −0.0915379 
                 3023 
                 Hs.170915 
                 Hs.34579 
                 117 
               
               
                   
               
               
                 NM_003944 
                 SELENBP1 
                 −0.079434 
                 3129 
                 Hs.334841 
                 Hs.334841 
                 118 
               
               
                   
               
               
                 NM_017455 
                 SDFR1 
                 0.0595179 
                 3144 
                 Hs.389371 
                 Hs.389371 
                 119 
               
               
                   
               
               
                 AB029032 
                 KIAA1109 
                 −0.0509789 
                 3156 
                 Hs.408142 
                 Hs.6606 
                 120 
               
               
                   
               
               
                 Contig37141_RC 
                   
                 −0.0131654 
                 3168 
                 Hs.483205 
                 Hs.432790 
                 121 
               
               
                   
               
               
                 NM_004906 
                 KIAA0105 
                 0.0688316 
                 3196 
                 Hs.446091 
                 Hs.119 
                 122 
               
               
                   
               
               
                 NM_005167 
                 ARHC 
                 0.0171709 
                 3199 
                 Hs.179735 
                 Hs.179735 
                 123 
               
               
                   
               
               
                 Contig50396_RC 
                   
                 −0.0021026 
                 3356 
                 Hs.4094 
                 Hs.4094 
                 124 
               
               
                   
               
               
                 NM_003793 
                 CTSF 
                 −0.0367427 
                 3371 
                 Hs.11590 
                 Hs.11590 
                 125 
               
               
                   
               
               
                 NM_006347 
                 USA-CYP 
                 −0.0609369 
                 3381 
                 Hs.9880 
                 Hs.9880 
                 126 
               
               
                   
               
               
                 AB033034 
                 DKFZp762B226 
                 0.011291 
                 3402 
                 Hs.412128 
                 Hs.7041 
                 127 
               
               
                   
               
               
                 NM_001706 
                 BCL6 
                 −0.0877042 
                 3427 
                 Hs.155024 
                 Hs.155024 
                 128 
               
               
                   
               
               
                 NM_016217 
                 LOC51696 
                 0.0255174 
                 3461 
                 Hs.6679 
                 Hs.6679 
                 129 
               
               
                   
               
               
                 AL049949 
                   
                 −0.0204419 
                 3475 
                 Hs.28264 
                 Hs.28264 
                 130 
               
               
                   
               
               
                 NM_001482 
                 GATM 
                 −0.1357806 
                 3642 
                 Hs.75335 
                 Hs.75335 
                 131 
               
               
                   
               
               
                 NM_001551 
                 IGBP1 
                 −0.011337 
                 3653 
                 Hs.3631 
                 Hs.3631 
                 132 
               
               
                   
               
               
                 NM_005360 
                 MAF 
                 −0.0302207 
                 3661 
                 Hs.134859 
                 Hs.30250 
                 133 
               
               
                   
               
               
                 NM_014454 
                 PA26 
                 0.0255216 
                 3672 
                 Hs.14125 
                 Hs.14125 
                 134 
               
               
                   
               
               
                 Contig52737_RC 
                   
                 −0.14461 
                 3708 
                 Hs.31297 
                 Hs.31297 
                 135 
               
               
                   
               
               
                 NM_006303 
                 JTV1 
                 0.001045 
                 3734 
                 Hs.301613 
                 Hs.301613 
                 136 
               
               
                   
               
               
                 NM_012428 
                 SDFR1 
                 0.0758822 
                 3739 
                 Hs.389371 
                 Hs.389371 
                 137 
               
               
                   
               
               
                 NM_016103 
                 LOC51128 
                 0.0062434 
                 3745 
                 Hs.279582 
                 Hs.279582 
                 138 
               
               
                   
               
               
                 NM_016065 
                 LOC51021 
                 −0.0124273 
                 3815 
                 Hs.180312 
                 Hs.180312 
                 139 
               
               
                   
               
               
                 NM_020188 
                 DC13 
                 0.0854393 
                 3824 
                 Hs.6879 
                 Hs.6879 
                 140 
               
               
                   
               
               
                 NM_002185 
                 IL7R 
                 0.1228947 
                 3856 
                 Hs.362807 
                 Hs.362807 
                 141 
               
               
                   
               
               
                 NM_000099 
                 CST3 
                 −0.0058468 
                 3913 
                 Hs.304682 
                 Hs.304682 
                 142 
               
               
                   
               
               
                 NM_001152 
                 SLC25A5 
                 0.0536659 
                 3917 
                 Hs.79172 
                 Hs.79172 
                 143 
               
               
                   
               
               
                 NM_014669 
                 KIAA0095 
                 0.0385347 
                 3937 
                 Hs.295014 
                 Hs.155314 
                 144 
               
               
                   
               
               
                 NM_003093 
                 SNRPC 
                 0.0193292 
                 4128 
                 Hs.1063 
                 Hs.1063 
                 145 
               
               
                   
               
               
                 NM_003115 
                 UAP1 
                 0.0057854 
                 4130 
                 Hs.21293 
                 Hs.21293 
                 146 
               
               
                   
               
               
                 NM_012333 
                 MYC8P 
                 0.0681289 
                 4145 
                 Hs.78221 
                 Hs.78221 
                 147 
               
               
                   
               
               
                 NM_014909 
                 KIAA1036 
                 −0.0282497 
                 4153 
                 Hs.155182 
                 Hs.155182 
                 148 
               
               
                   
               
               
                 NM_019903 
                 ADD3 
                 0.100385 
                 4163 
                 Hs.324470 
                 Hs.324470 
                 149 
               
               
                   
               
               
                 NM_001286 
                 CLCN6 
                 0.0071871 
                 4209 
                 Hs.371458 
                 Hs.211614 
                 150 
               
               
                   
               
               
                 NM_018287 
                 FLJ10971 
                 0.0784592 
                 4241 
                 Hs.396643 
                 Hs.13531 
                 151 
               
               
                   
               
               
                 AL133555 
                 CCT8 
                 0.0567524 
                 4252 
                 Hs.143736 
                 Hs.352413 
                 152 
               
               
                   
               
               
                 NM_004508 
                 IDI1 
                 0.0725287 
                 4295 
                 Hs.76038 
                 Hs.76038 
                 153 
               
               
                   
               
               
                 NM_000062 
                 SERPING1 
                 0.0299511 
                 4364 
                 Hs.384598 
                 Hs.151242 
                 154 
               
               
                   
               
               
                 NM_000373 
                 UMPS 
                 −0.0990897 
                 4366 
                 Hs.2057 
                 Hs.2057 
                 155 
               
               
                   
               
               
                 NM_021199 
                 CGI-44 
                  4.57E−04 
                 4403 
                 Hs.435468 
                 Hs.8185 
                 156 
               
               
                   
               
               
                 Contig54898_RC 
                   
                 0.0388843 
                 4438 
                 Hs.424126 
                 Hs.356688 
                 157 
               
               
                   
               
               
                 NM_000788 
                 DCK 
                 0.0926807 
                 4451 
                 Hs.709 
                 Hs.709 
                 158 
               
               
                   
               
               
                 NM_004301 
                 BAF53A 
                 0.0095139 
                 4461 
                 Hs.435326 
                 Hs.274350 
                 159 
               
               
                   
               
               
                 NM_004593 
                 SFRS10 
                 0.0762501 
                 4463 
                 Hs.30035 
                 Hs.30035 
                 160 
               
               
                   
               
               
                 NM_005517 
                 HMG17 
                 0.0691543 
                 4467 
                 Hs.181163 
                 Hs.181163 
                 161 
               
               
                   
               
               
                 NM_017838 
                 FLJ20479 
                 0.0029758 
                 4634 
                 Hs.386392 
                 Hs.23990 
                 162 
               
               
                   
               
               
                 NM_018243 
                 FLJ10849 
                 −0.0218507 
                 4636 
                 Hs.386784 
                 Hs.8768 
                 163 
               
               
                   
               
               
                 Contig55612_RC 
                   
                 −0.0311422 
                 4675 
                 Hs.267120 
                 Hs.267120 
                 164 
               
               
                   
               
               
                 Contig40105 
                   
                 −7.78E−07 
                 4733 
                 Hs.350388 
                 Hs.350388 
                 165 
               
               
                   
               
               
                 NM_003091 
                 SNRPB 
                 0.0142074 
                 4759 
                 Hs.83753 
                 Hs.83753 
                 166 
               
               
                   
               
               
                 Contig46583_RC 
                   
                 −0.0198152 
                 4825 
                 Hs.191320 
                 Hs.380474 
                 167 
               
               
                   
               
               
                 NM_012321 
                 LSM4 
                 0.0303369 
                 4870 
                 Hs.76719 
                 Hs.76719 
                 168 
               
               
                   
               
               
                 NM_014905 
                 GL5 
                 −0.095738 
                 5041 
                 Hs.128410 
                 Hs.239189 
                 169 
               
               
                   
               
               
                 NM_016639 
                 FN14 
                 −0.0306102 
                 5047 
                 Hs.355899 
                 Hs.355899 
                 170 
               
               
                   
               
               
                 Contig52717_RC 
                   
                 0.0127462 
                 5084 
                 Hs.356618 
                 Hs.356618 
                 171 
               
               
                   
               
               
                 Contig58129_RC 
                   
                 −0.0547341 
                 5092 
                 Hs.163725 
                 Hs.163725 
                 172 
               
               
                   
               
               
                 AK002107 
                   
                 −0.1842058 
                 5158 
                 Hs.123072 
                 Hs.20843 
                 173 
               
               
                   
               
               
                 NM_002687 
                 PNN 
                 −0.1029911 
                 5187 
                 Hs.409965 
                 Hs.44499 
                 174 
               
               
                   
               
               
                 NM_002808 
                 PSMD2 
                 0.033058 
                 5191 
                 Hs.388921 
                 Hs.74619 
                 175 
               
               
                   
               
               
                 NM_014325 
                 CORO1C 
                 −0.0520972 
                 5220 
                 Hs.17377 
                 Hs.17377 
                 176 
               
               
                   
               
               
                 AL110212 
                 PURB 
                 0.01098946 
                 5244 
                 Hs.301005 
                 Hs.301005 
                 177 
               
               
                   
               
               
                 NM_003374 
                 VDAC1 
                 −0.0376429 
                 5284 
                 Hs.404814 
                 Hs.149155 
                 178 
               
               
                   
               
               
                 L48692 
                 LOC56902 
                 0.0353168 
                 5354 
                 Hs.262858 
                 Hs.193384 
                 179 
               
               
                   
               
               
                 NM_001745 
                 CAMLG 
                 −0.0106132 
                 5360 
                 Hs.13572 
                 Hs.13572 
                 180 
               
               
                   
               
               
                 NM_002659 
                 PLAUR 
                 −0.045088 
                 5366 
                 Hs.179657 
                 Hs.179657 
                 181 
               
               
                   
               
               
                 U09579 
                 CPNE5 
                 −0.0288579 
                 5403 
                 Hs.370771 
                 Hs.179665 
                 182 
               
               
                   
               
               
                 AL050353 
                 OIP2 
                 0.0667026 
                 5417 
                 Hs.274170 
                 Hs.274170 
                 183 
               
               
                   
               
               
                 NM_003707 
                 RUVBL1 
                 −0.1009717 
                 5455 
                 Hs.272822 
                 Hs.272822 
                 184 
               
               
                   
               
               
                 NM_006397 
                 RNASEHI 
                 0.0568056 
                 5469 
                 Hs.25292 
                 Hs.25292 
                 185 
               
               
                   
               
               
                 NM_020143 
                 LOC56902 
                 0.0169222 
                 5485 
                 Hs.262858 
                 Hs.193384 
                 186 
               
               
                   
               
               
                 Contig38493_RC 
                   
                 0.0565596 
                 5511 
                 Hs.509629 
                 Hs.17767 
                 187 
               
               
                   
               
               
                 NM_002137 
                 HNRPA2B1 
                 0.047456 
                 5613 
                 Hs.232400 
                 Hs.232400 
                 188 
               
               
                   
               
               
                 NM_005805 
                 POH1 
                 0.069186 
                 5631 
                 Hs.178761 
                 Hs.178761 
                 189 
               
               
                   
               
               
                 NM_014350 
                 GG2-1 
                 0.0541893 
                 5644 
                 Hs.17839 
                 Hs.17839 
                 190 
               
               
                   
               
               
                 NM_018087 
                 FLJ10407 
                 −0.0295427 
                 5657 
                 Hs.435982 
                 Hs.30738 
                 191 
               
               
                   
               
               
                 AF113020 
                 PRO2463 
                 0.024994 
                 5667 
                 Hs.406243 
                 Hs.90421 
                 192 
               
               
                   
               
               
                 AK001163 
                 ADE2H1 
                 0.0522322 
                 5673 
                 Hs.444439 
                 Hs.117950 
                 193 
               
               
                   
               
               
                 Contig57034_RC 
                   
                 −0.001299 
                 5796 
                 Hs.127337 
                 Hs.127337 
                 194 
               
               
                   
               
               
                 NM_002431 
                 MNAT1 
                 0.0182942 
                 5807 
                 Hs.72870 
                 Hs.433410 
                 195 
               
               
                   
               
               
                 NM_004461 
                 FARSL 
                 0.0126879 
                 5815 
                 Hs.23111 
                 Hs.23111 
                 196 
               
               
                   
               
               
                 NM_007107 
                 SSR3 
                 0.0756157 
                 5826 
                 Hs.28707 
                 Hs.28707 
                 197 
               
               
                   
               
               
                 U09848 
                 ZNF36 
                 0.0324513 
                 5844 
                 Hs.528676 
                 Hs.356344 
                 198 
               
               
                   
               
               
                 NM_020401 
                 NUP107 
                 0.0642592 
                 5939 
                 Hs.355598 
                 Hs.236204 
                 199 
               
               
                   
               
               
                 NM_016271 
                 STRIN 
                 0.0660269 
                 6140 
                 Hs.180403 
                 Hs.180403 
                 200 
               
               
                   
               
               
                 NM_002452 
                 NUDT1 
                 −0.0117806 
                 6211 
                 Hs.413078 
                 Hs.388 
                 201 
               
               
                   
               
               
                 NM_018290 
                 FLJ10983 
                 −0.0173684 
                 6256 
                 Hs.23363 
                 Hs.23363 
                 202 
               
               
                   
               
               
                 X66087 
                 MYBL1 
                 −0.0303777 
                 6261 
                 Hs.300592 
                 Hs.300592 
                 203 
               
               
                   
               
               
                 Contig20651_RC 
                   
                 0.0977492 
                 6363 
                 Hs.180403 
                 Hs.180403 
                 204 
               
               
                   
               
               
                 NM_016491 
                 MRPL37 
                 0.0466628 
                 6424 
                 Hs.4209 
                 Hs.4209 
                 205 
               
               
                   
               
               
                 D80010 
                 LPIN1 
                 −0.0185498 
                 6473 
                 Hs.81412 
                 Hs.81412 
                 206 
               
               
                   
               
               
                 NM_006618 
                 PLU-1 
                 −0.0720389 
                 6494 
                 Hs.143323 
                 Hs.143323 
                 207 
               
               
                   
               
               
                 AB020681 
                 KIAA0874 
                 −0.1063096 
                 6522 
                 Hs.388877 
                 Hs.27973 
                 208 
               
               
                   
               
               
                 Contig41864_RC 
                   
                 −0.0153596 
                 6547 
                 Hs.188199 
                 Hs.15220 
                 209 
               
               
                   
               
               
                 NM_002949 
                 MRPL12 
                 −0.0402533 
                 6583 
                 Hs.109059 
                 Hs.109059 
                 210 
               
               
                   
               
               
                 NM_005920 
                 MEF2D 
                 −0.0251423 
                 6594 
                 Hs.77955 
                 Hs.77955 
                 211 
               
               
                   
               
               
                 NM_003089 
                 SNRP70 
                 −0.008649 
                 6684 
                 Hs.174051 
                 Hs.174051 
                 212 
               
               
                   
               
               
                 NM_016134 
                 LOC51670 
                 −0.0149143 
                 6712 
                 Hs.197335 
                 Hs.197335 
                 213 
               
               
                   
               
               
                 NM_016326 
                 LOC51192 
                 0.0542734 
                 6717 
                 Hs.15159 
                 Hs.15159 
                 214 
               
               
                   
               
               
                 NM_005826 
                 HNRPR 
                 0.0151329 
                 6817 
                 Hs.15265 
                 Hs.15265 
                 215 
               
               
                   
               
               
                 NM_012417 
                 RDGBB 
                 0.0476858 
                 6826 
                 Hs.405933 
                 Hs.333212 
                 216 
               
               
                   
               
               
                 NM_016567 
                 TOK-1 
                 0.0054519 
                 6840 
                 Hs.337008 
                 Hs.279862 
                 217 
               
               
                   
               
               
                 D55716 
                 MCM7 
                 0.0157898 
                 6910 
                 Hs.438720 
                 Hs.77152 
                 218 
               
               
                   
               
               
                 NM_004953 
                 EIF4G1 
                 0.002703 
                 6934 
                 Hs.433750 
                 Hs.433750 
                 219 
               
               
                   
               
               
                 NM_006824 
                 P40 
                 0.0316377 
                 6944 
                 Hs.346868 
                 Hs.346868 
                 220 
               
               
                   
               
               
                 NM_014413 
                 HRI 
                 0.0059656 
                 6950 
                 Hs.434986 
                 Hs.258730 
                 221 
               
               
                   
               
               
                 NM_019555 
                 ARHGEF3 
                 0.0119673 
                 6966 
                 Hs.25951 
                 Hs.25951 
                 222 
               
               
                   
               
               
                 AB033054 
                 KIAA1228 
                 0.0195106 
                 6973 
                 Hs.388073 
                 Hs.306867 
                 223 
               
               
                   
               
               
                 NM_004095 
                 EIF4EBP1 
                 0.0021399 
                 7044 
                 Hs.406408 
                 Hs.4333137 
                 224 
               
               
                   
               
               
                 NM_006833 
                 MOV34-34KD 
                 −0.0384261 
                 7062 
                 Hs.15591 
                 Hs.15591 
                 225 
               
               
                   
               
               
                 NM_012325 
                 MAPRE1 
                 −0.0165868 
                 7070 
                 Hs.408754 
                 Hs.234279 
                 226 
               
               
                   
               
               
                 NM_016183 
                 LOC51154 
                 0.015694 
                 7076 
                 Hs.463797 
                 Hs.274201 
                 227 
               
               
                   
               
               
                 AB040969 
                 KIAA1536 
                 −0.0540262 
                 7098 
                 Hs.156667 
                 Hs.156667 
                 228 
               
               
                   
               
               
                 Contig43506_RC 
                   
                 0.0382747 
                 7128 
                 Hs.511765 
                 Hs.154762 
                 229 
               
               
                   
               
               
                 Contig719_RC 
                   
                 0.064509 
                 7144 
                 Hs.120425 
                 Hs.22350 
                 230 
               
               
                   
               
               
                 NM_005956 
                 MTHFD1 
                 0.0511302 
                 7171 
                 Hs.435974 
                 Hs.172665 
                 231 
               
               
                   
               
               
                 NM_006938 
                 SNRPD1 
                 0.0929607 
                 7173 
                 Hs.86948 
                 Hs.86948 
                 232 
               
               
                   
               
               
                 NM_016310 
                 POLR3K 
                 0.029813 
                 7184 
                 Hs.437186 
                 Hs.110857 
                 233 
               
               
                   
               
               
                 NM_016546 
                 LOC51279 
                 −0.021692 
                 7304 
                 Hs.415792 
                 Hs.98571 
                 234 
               
               
                   
               
               
                 NM_016607 
                 ALEX3 
                 −0.0289851 
                 7305 
                 Hs.172788 
                 Hs.172788 
                 235 
               
               
                   
               
               
                 X69111 
                 ID3 
                 0.0048616 
                 7319 
                 Hs.76884 
                 Hs.76884 
                 236 
               
               
                   
               
               
                 AF052183 
                   
                 −0.0091578 
                 7326 
                 Hs.446551 
                 Hs.11039 
                 237 
               
               
                   
               
               
                 AK000685 
                   
                 −0.0520794 
                 7330 
                 Hs.143601 
                 Hs.143601 
                 238 
               
               
                   
               
               
                 Contig3902_RC 
                   
                 −0.0190224 
                 7345 
                 Hs.26812 
                 Hs.26812 
                 239 
               
               
                   
               
               
                 NM_013300 
                 HSU79274 
                 −0.0264869 
                 7415 
                 Hs.150555 
                 H.150555 
                 240 
               
               
                   
               
               
                 Contig47710_RC 
                   
                 0.0739388 
                 7477 
                 Hs.98133 
                 Hs.98133 
                 241 
               
               
                   
               
               
                 NM_002004 
                 FDPS 
                  6.79E−04 
                 7502 
                 Hs.335918 
                 Hs.335918 
                 242 
               
               
                   
               
               
                 NM_003051 
                 SLC16A1 
                 0.03463 
                 7645 
                 Hs.75231 
                 Hs.75231 
                 243 
               
               
                   
               
               
                 NM_003064 
                 SLPI 
                 0.0711473 
                 7646 
                 Hs.251754 
                 Hs.251754 
                 244 
               
               
                   
               
               
                 NM_006452 
                 ADE2H1 
                 −0.0167971 
                 7660 
                 Hs.444439 
                 Hs.117950 
                 245 
               
               
                   
               
               
                 Contig54752_RC 
                   
                 0.0036688 
                 7767 
                 Hs.69476 
                 Hs.69476 
                 246 
               
               
                   
               
               
                 M94362 
                 LMNB2 
                 −0.0129366 
                 7777 
                 Hs.76084 
                 Hs.76084 
                 247 
               
               
                   
               
               
                 Contig49652_RC 
                   
                 0.0642718 
                 7924 
                 Hs.374421 
                 Hs.374421 
                 248 
               
               
                   
               
               
                 Contig56840_RC 
                   
                 −0.0153949 
                 7932 
                 Hs.8026 
                 Hs.8026 
                 249 
               
               
                   
               
               
                 NM_020185 
                 MKPX 
                 −0.02206 
                 8034 
                 Hs.29106 
                 Hs.29106 
                 250 
               
               
                   
               
               
                 NM_007021 
                 DEPP 
                 −0.0060809 
                 8158 
                 Hs.93675 
                 Hs.93675 
                 251 
               
               
                   
               
               
                 NM_014264 
                 STK1B 
                 −0.0244607 
                 8175 
                 Hs.172052 
                 Hs.172052 
                 252 
               
               
                   
               
               
                 AL133577 
                   
                 0.0975647 
                 8241 
                 Hs.106148 
                 Hs.106148 
                 253 
               
               
                   
               
               
                 NM_003016 
                 SFRS2 
                 0.0251001 
                 8340 
                 Hs.73965 
                 Hs.73965 
                 254 
               
               
                   
               
               
                 NM_002466 
                 MYBL2 
                 0.028428 
                 8500 
                 Hs.179718 
                 Hs.179718 
                 255 
               
               
                   
               
               
                 NM_006988 
                 ADAMTS1 
                 −0.0837017 
                 8537 
                 Hs.8230 
                 Hs.8230 
                 256 
               
               
                   
               
               
                 NM_016391 
                 HSPC111 
                 0.0234483 
                 8552 
                 Hs.529475 
                 Hs.279918 
                 257 
               
               
                   
               
               
                 NM_017787 
                 FLJ20367 
                 −0.0563849 
                 8557 
                 Hs.10346 
                 Hs.10346 
                 258 
               
               
                   
               
               
                 NM_017816 
                 FLJ20425 
                 0.0125463 
                 8559 
                 Hs.425427 
                 Hs.425427 
                 259 
               
               
                   
               
               
                 NM_021019 
                 MYL6 
                 −0.0399657 
                 8568 
                 Hs.77385 
                 Hs.77385 
                 260 
               
               
                   
               
               
                 NM_002388 
                 MCM3 
                 0.0231119 
                 8700 
                 Hs.179565 
                 Hs.179565 
                 261 
               
               
                   
               
               
                 NM_003132 
                 SRM 
                 0.0567747 
                 8706 
                 Hs.76244 
                 Hs.76244 
                 262 
               
               
                   
               
               
                 NM_004280 
                 EEF1E1 
                 0.0296196 
                 8712 
                 Hs.88977 
                 Hs.433779 
                 263 
               
               
                   
               
               
                 AB036063 
                 p53R2 
                 −0.018041 
                 8785 
                 Hs.512592 
                 Hs.94262 
                 264 
               
               
                   
               
               
                 Contig20635_RC 
                   
                 −0.0706198 
                 8813 
                 Hs.412128 
                 Hs.7041 
                 265 
               
               
                   
               
               
                 Contig51797_RC 
                   
                  8.73E−04 
                 8874 
                 Hs.42474 
                 Hs.108873 
                 266 
               
               
                   
               
               
                 NM_002184 
                 IL6ST 
                 −0.0810843 
                 8908 
                 Hs.71968 
                 Hs.82065 
                 267 
               
               
                   
               
               
                 NM_006534 
                 NCOA3 
                 0.0349513 
                 8942 
                 Hs.382168 
                 Hs.225977 
                 268 
               
               
                   
               
               
                 NM_016613 
                 LOC51313 
                 0.0140286 
                 8956 
                 Hs.323583 
                 Hs.323583 
                 269 
               
               
                   
               
               
                 NM_002971 
                 SATB1 
                 −0.0344931 
                 9137 
                 Hs.416026 
                 Hs.74592 
                 270 
               
               
                   
               
               
                 NM_005785 
                 SBB103 
                 0.0196583 
                 9163 
                 Hs.436596 
                 Hs.153639 
                 271 
               
               
                   
               
               
                 NM_017768 
                 FLJ20331 
                 0.0386201 
                 9206 
                 Hs.283862 
                 Hs.50848 
                 272 
               
               
                   
               
               
                 NM_018381 
                 FLJ11286 
                 0.0168729 
                 9219 
                 Hs.175120 
                 Hs.12151 
                 273 
               
               
                   
               
               
                 U79458 
                 WBP2 
                 0.0361998 
                 9232 
                 # N/A 
                 Hs.231840 
                 274 
               
               
                   
               
               
                 AF054996 
                   
                 −0.0422692 
                 9245 
                 Hs.91579 
                 Hs.91579 
                 275 
               
               
                   
               
               
                 AL079279 
                   
                 −0.0035211 
                 9257 
                 Hs.231971 
                 Hs.8963 
                 276 
               
               
                   
               
               
                 Contig24856_RC 
                   
                 −0.0378088 
                 9272 
                 Hs.9028 
                 Hs.9028 
                 277 
               
               
                   
               
               
                 Contig2493_RC 
                   
                 0.0189361 
                 9273 
                 # N/A 
                 Hs.256302 
                 278 
               
               
                   
               
               
                 Contig49757_RC 
                   
                 0.0468612 
                 9321 
                 Hs.1600 
                 Hs.1600 
                 279 
               
               
                   
               
               
                 NM_004596 
                 SNRPA 
                 0.0022191 
                 9403 
                 Hs.173255 
                 Hs.173255 
                 280 
               
               
                   
               
               
                 NM_006396 
                 SSSCA1 
                 0.0027079 
                 9421 
                 Hs.25723 
                 Hs.25723 
                 281 
               
               
                   
               
               
                 NM_007066 
                 PKIG 
                 −0.0135997 
                 9425 
                 Hs.3407 
                 Hs.3407 
                 282 
               
               
                   
               
               
                 AB037784 
                 KIAA1363 
                 0.0220583 
                 9482 
                 Hs.22941 
                 Hs.22941 
                 283 
               
               
                   
               
               
                 Contig37368_RC 
                   
                 0.1016643 
                 9560 
                 Hs.3532 
                 Hs.17767 
                 284 
               
               
                   
               
               
                 NM_005704 
                 PTPRU 
                 −0.0037938 
                 9682 
                 Hs.19718 
                 Hs.19718 
                 285 
               
               
                   
               
               
                 NM_005796 
                 PP15 
                 0.0747884 
                 9683 
                 Hs.356630 
                 Hs.151734 
                 286 
               
               
                   
               
               
                 AB002321 
                 KIAA0323 
                 −0.0399421 
                 9748 
                 Hs.7911 
                 Hs.7911 
                 287 
               
               
                   
               
               
                 AF055016 
                 LOC57213 
                 0.0695341 
                 9759 
                 Hs.44235 
                 Hs.44235 
                 288 
               
               
                   
               
               
                 Contig48842_RC 
                   
                 −0.0020714 
                 9863 
                 Hs.444449 
                 Hs.29088 
                 289 
               
               
                   
               
               
                 NM_001274 
                 CHEK1 
                 0.0441693 
                 9902 
                 Hs.24529 
                 Hs.20295 
                 290 
               
               
                   
               
               
                 NM_002692 
                 POLE2 
                 0.0495898 
                 9926 
                 Hs.99185 
                 Hs.99185 
                 291 
               
               
                   
               
               
                 NM_006444 
                 CAP-E 
                 0.0214551 
                 9971 
                 Hs.119023 
                 Hs.119023 
                 292 
               
               
                   
               
               
                 NM_014977 
                 KIAA0670 
                 −0.0148572 
                 10005 
                 Hs.227133 
                 Hs.227133 
                 293 
               
               
                   
               
               
                 NM_016126 
                 LOC51668 
                 0.0123531 
                 10012 
                 Hs.439171 
                 Hs.46967 
                 294 
               
               
                   
               
               
                 Contig53132_RC 
                   
                 −0.001413 
                 10219 
                 Hs.119023 
                 Hs.119023 
                 295 
               
               
                   
               
               
                 NM_000935 
                 PLOD2 
                 0.0042861 
                 10257 
                 Hs.41270 
                 Hs.41270 
                 296 
               
               
                   
               
               
                 M31212 
                 MYL6 
                 −0.0268881 
                 10601 
                 Hs.77385 
                 Hs.77385 
                 297 
               
               
                   
               
               
                 NM_005928 
                 MFGE8 
                 −0.0444387 
                 10696 
                 Hs.3745 
                 Hs.3745 
                 298 
               
               
                   
               
               
                 AK001025 
                   
                 0.0331707 
                 10821 
                 Hs.9081 
                 Hs.9081 
                 299 
               
               
                   
               
               
                 AL049435 
                   
                 −0.0408307 
                 10831 
                 Hs.407903 
                 Hs.170056 
                 300 
               
               
                   
               
               
                 AL157475 
                   
                 0.0418432 
                 10846 
                 Hs.318791 
                 Hs.35453 
                 301 
               
               
                   
               
               
                 Contig43868_RC 
                 FLJ12810 
                 −0.0083923 
                 10958 
                 Hs.115660 
                 Hs.115660 
                 302 
               
               
                   
               
               
                 NM_002804 
                 PSMC3 
                 0.0481223 
                 11082 
                 Hs.250758 
                 Hs.250758 
                 303 
               
               
                   
               
               
                 NM_002915 
                 RFC3 
                 0.0297288 
                 11084 
                 Hs.115474 
                 Hs.115474 
                 304 
               
               
                   
               
               
                 NM_004102 
                 FABP3 
                 0.0062634 
                 11108 
                 Hs.112669 
                 Hs.49881 
                 305 
               
               
                   
               
               
                 Contig40852_RC 
                   
                 −0.0039597 
                 11424 
                 Hs.287850 
                 Hs.20295 
                 306 
               
               
                   
               
               
                 Contig41097_RC 
                   
                 −0.0240801 
                 11428 
                 Hs.434229 
                 Hs.283077 
                 307 
               
               
                   
               
               
                 Contig53180_RC 
                   
                 0.0163097 
                 11509 
                 Hs.293943 
                 Hs.293943 
                 308 
               
               
                   
               
               
                 D42044 
                 KIAA0090 
                 0.032282 
                 11543 
                 Hs.439200 
                 Hs.154797 
                 309 
               
               
                   
               
               
                 NM_006638 
                 RPP40 
                 0.0186764 
                 11652 
                 Hs.511756 
                 Hs.115823 
                 310 
               
               
                   
               
               
                 NM_014060 
                 MCT-1 
                  3.32E−04 
                 11677 
                 Hs.102696 
                 Hs.102696 
                 311 
               
               
                   
               
               
                 NM_014891 
                 HASPP28 
                 0.0012986 
                 11688 
                 Hs.278426 
                 Hs.278426 
                 312 
               
               
                   
               
               
                 NM_018948 
                 MIG-6 
                 0.0185109 
                 11731 
                 Hs.11169 
                 Hs.11169 
                 313 
               
               
                   
               
               
                 Contig51654_RC 
                   
                 −0.0209143 
                 12014 
                 Hs.110783 
                 Hs.110783 
                 314 
               
               
                   
               
               
                 NM_002221 
                 TTPKB 
                 0.0298442 
                 12126 
                 Hs.78877 
                 Hs.78877 
                 315 
               
               
                   
               
               
                 NM_002461 
                 MVD 
                 0.0362217 
                 12130 
                 Hs.252457 
                 Hs.3828 
                 316 
               
               
                   
               
               
                 NM_002611 
                 PDK2 
                 0.0545401 
                 12140 
                 Hs.92261 
                 Hs.92261 
                 317 
               
               
                   
               
               
                 NM_005542 
                 INSIG1 
                 0.0157828 
                 12209 
                 Hs.416385 
                 Hs.56205 
                 318 
               
               
                   
               
               
                 NM_005887 
                 DLEU1 
                 0.0071237 
                 12217 
                 Hs.344524 
                 Hs.20149 
                 319 
               
               
                   
               
               
                 NM_017644 
                 FLJ20059 
                 0.0132037 
                 12294 
                 Hs.246875 
                 Hs.246875 
                 320 
               
               
                   
               
               
                 NM_017955 
                 FLJ20764 
                 0.0395443 
                 12302 
                 Hs.34045 
                 Hs.34045 
                 321 
               
               
                   
               
               
                 NM_017975 
                 FLJ10036 
                 0.0306823 
                 12304 
                 Hs.21331 
                 Hs.21331 
                 322 
               
               
                   
               
               
                 NM_018300 
                 FLJ11015 
                 −0.0271833 
                 12310 
                 Hs.305953 
                 Hs.305953 
                 323 
               
               
                   
               
               
                 NM_019610 
                 LOC56267 
                 0.0269821 
                 12324 
                 Hs.134460 
                 Hs.180378 
                 324 
               
               
                   
               
               
                 AB040964 
                 DKFZP434C211 
                 0.0048844 
                 12371 
                 Hs.17270 
                 Hs.17270 
                 325 
               
               
                   
               
               
                 Contig3794_RC 
                   
                 0.0229191 
                 12610 
                 Hs.188199 
                 Hs.15220 
                 326 
               
               
                   
               
               
                 NM_001458 
                 FLNC 
                 −0.0597353 
                 12842 
                 Hs.58414 
                 Hs.58414 
                 327 
               
               
                   
               
               
                 AB037726 
                 KIAA1305 
                 −0.0361304 
                 13165 
                 Hs.288348 
                 Hs.288348 
                 328 
               
               
                   
               
               
                 AF070559 
                   
                 0.0753652 
                 13178 
                 Hs.398111 
                 Hs.13413 
                 329 
               
               
                   
               
               
                 Contig30070_RC 
                   
                 0.0429576 
                 13446 
                 Hs.380126 
                 Hs.177781 
                 330 
               
               
                   
               
               
                 Contig36836_RC 
                   
                 −0.023683 
                 13540 
                 Hs.163725 
                 Hs.163725 
                 331 
               
               
                   
               
               
                 Contig37066_RC 
                 LOC56926 
                 −0.0298591 
                 13542 
                 Hs.24983 
                 Hs.24983 
                 332 
               
               
                   
               
               
                 Contig42355_RC 
                   
                 0.0014493 
                 13631 
                 Hs.55080 
                 Hs.55080 
                 333 
               
               
                   
               
               
                 Contig48716_RC 
                 DUT 
                 0.0613151 
                 13705 
                 Hs.367676 
                 Hs.367676 
                 334 
               
               
                   
               
               
                 Contig52675_RC 
                   
                 0.0259649 
                 13750 
                 Hs.131887 
                 Hs.34359 
                 335 
               
               
                   
               
               
                 Contig53315_RC 
                   
                 0.0036247 
                 13756 
                 Hs.180591 
                 Hs.180591 
                 336 
               
               
                   
               
               
                 Contig705_RC 
                   
                 −0.0026919 
                 13823 
                 Hs.257267 
                 Hs.257267 
                 337 
               
               
                   
               
               
                 NM_000542 
                 SFTPB 
                 0.0385978 
                 13872 
                 Hs.512690 
                 Hs.76305 
                 338 
               
               
                   
               
               
                 NM_005328 
                 HAS2 
                 −0.0158281 
                 14071 
                 Hs.159226 
                 Hs.159226 
                 339 
               
               
                   
               
               
                 NM_005954 
                 MT3 
                 0.0129362 
                 14091 
                 Hs.73133 
                 Hs.73133 
                 340 
               
               
                   
               
               
                 NM_014904 
                 KIAA0941 
                 −0.0243201 
                 14194 
                 Hs.173656 
                 Hs.173656 
                 341 
               
               
                   
               
               
                 NM_016021 
                 LOC51632 
                 0.0685857 
                 14212 
                 Hs.184325 
                 Hs.184325 
                 342 
               
               
                   
               
               
                 NM_016485 
                 HSPC228 
                 0.0141849 
                 14224 
                 Hs.267288 
                 Hs.267288 
                 343 
               
               
                   
               
               
                 NM_016621 
                 LOC51317 
                 0.0100728 
                 14231 
                 Hs.104888 
                 Hs.106826 
                 344 
               
               
                   
               
               
                 NM_018451 
                 BM032 
                 −0.0298676 
                 14264 
                 Hs.434229 
                 Hs.283077 
                 345 
               
               
                   
               
               
                 NM_020139 
                 LOC56898 
                 −0.0347826 
                 14291 
                 Hs.124696 
                 Hs.124696 
                 346 
               
               
                   
               
               
                 AB002365 
                 KIAA0367 
                 −0.0119917 
                 14333 
                 Hs.23311 
                 Hs.23311 
                 347 
               
               
                   
               
               
                 AB033080 
                 KIAA1254 
                 0.0377759 
                 14377 
                 Hs.259326 
                 Hs.82506 
                 348 
               
               
                   
               
               
                 AB033094 
                 KIAA1268 
                 0.0560176 
                 14378 
                 Hs.152925 
                 Hs.152925 
                 349 
               
               
                   
               
               
                 AF097495 
                   
                 0.0116724 
                 14421 
                 Hs.128410 
                 Hs.239189 
                 350 
               
               
                   
               
               
                 AL161983 
                   
                 0.0386629 
                 14573 
                 Hs.21415 
                 Hs.21415 
                 351 
               
               
                   
               
               
                 Contig20552_RC 
                 FLJ12810 
                 0.0213887 
                 14722 
                 Hs.115660 
                 Hs.115660 
                 352 
               
               
                   
               
               
                 Contig25390_RC 
                   
                 0.0416451 
                 14816 
                 Hs.12702 
                 Hs.12702 
                 353 
               
               
                   
               
               
                 Contig25794_RC 
                   
                 0.0300592 
                 14827 
                 Hs.440913 
                 Hs.173374 
                 354 
               
               
                   
               
               
                 Contig27901 
                   
                 0.0163827 
                 14874 
                 Hs.380763 
                 Hs.60293 
                 355 
               
               
                   
               
               
                 Contig28149_RC 
                   
                 0.0463053 
                 14886 
                 Hs.350388 
                 Hs.350388 
                 356 
               
               
                   
               
               
                 Contig45569_RC 
                   
                 0.0311039 
                 15328 
                 Hs.22116 
                 Hs.22116 
                 357 
               
               
                   
               
               
                 Contig565_RC 
                   
                 −0.0273416 
                 15542 
                 Hs.371609 
                 Hs.26418 
                 358 
               
               
                   
               
               
                 Contig58556_RC 
                 HN1L 
                 0.0163717 
                 15562 
                 Hs.437433 
                 Hs.172035 
                 359 
               
               
                   
               
               
                 NM_000504 
                 F10 
                 0.0481014 
                 15687 
                 Hs.361463 
                 Hs.47913 
                 360 
               
               
                   
               
               
                 NM_001503 
                 GPLD1 
                 0.041847 
                 15762 
                 Hs.512001 
                 Hs.272529 
                 361 
               
               
                   
               
               
                 NM_002130 
                 HMGCS1 
                 0.0261251 
                 15803 
                 Hs.397729 
                 Hs.77910 
                 362 
               
               
                   
               
               
                 NM_002340 
                 LSS 
                 0.0114226 
                 15812 
                 Hs.442223 
                 Hs.93199 
                 363 
               
               
                   
               
               
                 NM_003762 
                 VAMP4 
                 −0.0259544 
                 15905 
                 Hs.6651 
                 Hs.6651 
                 364 
               
               
                   
               
               
                 NM_003893 
                 LDB1 
                 0.0020439 
                 15919 
                 Hs.26002 
                 Hs.26002 
                 365 
               
               
                   
               
               
                 NM_004408 
                 DNM1 
                 0.0468998 
                 15958 
                 Hs.436132 
                 Hs.166161 
                 366 
               
               
                   
               
               
                 NM_004441 
                 EPHB1 
                 0.0014544 
                 15962 
                 Hs.272311 
                 Hs.78436 
                 367 
               
               
                   
               
               
                 NM_005177 
                 ATP6N1A 
                 0.0161722 
                 16026 
                 Hs.267871 
                 Hs.267871 
                 368 
               
               
                   
               
               
                 NM_005204 
                 MAP3K8 
                 0.0136797 
                 16027 
                 Hs.432453 
                 Hs.248 
                 369 
               
               
                   
               
               
                 NM_005474 
                 HDAC5 
                 −0.0060292 
                 16041 
                 Hs.9028 
                 Hs.9028 
                 370 
               
               
                   
               
               
                 NM_005687 
                 PheHB 
                 0.0290831 
                 16054 
                 Hs.9081 
                 Hs.9081 
                 371 
               
               
                   
               
               
                 NM_006764 
                 IFRD2 
                 0.0350204 
                 16116 
                 Hs.315177 
                 Hs.315177 
                 372 
               
               
                   
               
               
                 NM_007366 
                 PLA2R1 
                 −0.0170268 
                 16142 
                 Hs.410477 
                 Hs.171945 
                 373 
               
               
                   
               
               
                 NM_012268 
                 HU-K4 
                 0.0086049 
                 16163 
                 Hs.257008 
                 Hs.74573 
                 374 
               
               
                   
               
               
                 NM_015990 
                 LOC51088 
                 0.0234822 
                 16272 
                 Hs.272251 
                 Hs.272239 
                 375 
               
               
                   
               
               
                 AB002340 
                 KIAA0342 
                 0.0238402 
                 16480 
                 Hs.16950 
                 Hs.16950 
                 376 
               
               
                   
               
               
                 AB007867 
                 PLXNB1 
                 0.0023466 
                 16510 
                 Hs.278311 
                 Hs.278311 
                 377 
               
               
                   
               
               
                 AB033052 
                 KIAA1226 
                 0.0660662 
                 16619 
                 Hs.22151 
                 Hs.22151 
                 378 
               
               
                   
               
               
                 AJ225028 
                 GABBR1 
                 0.0341089 
                 16995 
                 Hs.167017 
                 Hs.167017 
                 379 
               
               
                   
               
               
                 AK001836 
                 LOC51088 
                 0.0089177 
                 17107 
                 Hs.272251 
                 Hs.272239 
                 380 
               
               
                   
               
               
                 AL110145 
                   
                 0.0021157 
                 17267 
                 Hs.483205 
                 Hs.432790 
                 381 
               
               
                   
               
               
                 AL110179 
                   
                 −0.0052602 
                 17273 
                 Hs.208414 
                 Hs.208414 
                 382 
               
               
                   
               
               
                 AL110255 
                   
                 −0.020197 
                 17284 
                 Hs.525899 
                 Hs.116808 
                 383 
               
               
                   
               
               
                 AL161961 
                 KIAA1554 
                 0.0357458 
                 17511 
                 Hs.195642 
                 Hs.17767 
                 384 
               
               
                   
               
               
                 Contig14968_RC 
                   
                 0.0031463 
                 17871 
                 Hs.441130 
                 Hs.34359 
                 385 
               
               
                   
               
               
                 Contig27451_RC 
                   
                 0.0149366 
                 18933 
                 Hs.150011 
                 Hs.150011 
                 386 
               
               
                   
               
               
                 Contig31351_RC 
                   
                 0.043506 
                 19392 
                 Hs.405933 
                 Hs.333212 
                 387 
               
               
                   
               
               
                 Contig34363_RC 
                   
                 0.0218431 
                 19737 
                 Hs.118630 
                 Hs.118630 
                 388 
               
               
                   
               
               
                 Contig34729_RC 
                   
                 0.0101084 
                 19787 
                 Hs.442658 
                 Hs.17767 
                 389 
               
               
                   
               
               
                 Contig34962_RC 
                   
                 0.0184084 
                 19817 
                 Hs.371609 
                 Hs.26418 
                 390 
               
               
                   
               
               
                 Contig35186_RC 
                   
                 0.0186019 
                 19845 
                 Hs.334612 
                 Hs.334612 
                 391 
               
               
                   
               
               
                 Contig36275 
                   
                 0.0800243 
                 19975 
                 Hs.446406 
                 Hs.43628 
                 392 
               
               
                   
               
               
                 Contig36750_RC 
                   
                 −0.0266751 
                 20018 
                 Hs.167017 
                 Hs.167017 
                 393 
               
               
                   
               
               
                 Contig40877_RC 
                   
                 −0.0198023 
                 20436 
                 Hs.445410 
                 Hs.29088 
                 394 
               
               
                   
               
               
                 Contig40885_RC 
                   
                 0.0388978 
                 20438 
                 Hs.44235 
                 Hs.44235 
                 395 
               
               
                   
               
               
                 Contig43133_RC 
                   
                 0.016295 
                 20653 
                 Hs.126706 
                 Hs.126706 
                 396 
               
               
                   
               
               
                 Contig4324_RC 
                 TUBA1 
                 0.0209023 
                 20663 
                 Hs.75318 
                 Hs.75318 
                 397 
               
               
                   
               
               
                 Contig43322_RC 
                   
                 0.0200381 
                 20669 
                 Hs.115474 
                 Hs.115474 
                 398 
               
               
                   
               
               
                 Contig493_RC 
                   
                 −0.0071587 
                 21132 
                 Hs.236025 
                 Hs.79 
                 399 
               
               
                   
               
               
                 Contig49966_RC 
                   
                 −0.027758 
                 21171 
                 Hs.371609 
                 Hs.25144 
                 400 
               
               
                   
               
               
                 Contig56681_RC 
                   
                 0.0371499 
                 21442 
                 Hs.301005 
                 Hs.301005 
                 401 
               
               
                   
               
               
                 Contig6089_RC 
                   
                 0.0033777 
                 21515 
                 # N/A 
                 Hs.388212 
                 402 
               
               
                   
               
               
                 Contig65995_RC 
                 ZNF262 
                 0.0191413 
                 21596 
                 Hs.150390 
                 Hs.109694 
                 403 
               
               
                   
               
               
                 Contig8054_RC 
                   
                 0.0128438 
                 21634 
                 Hs.357004 
                 Hs.94795 
                 404 
               
               
                   
               
               
                 Contig8896_RC 
                   
                 −0.0352637 
                 21682 
                 Hs.128410 
                 Hs.239189 
                 405 
               
               
                   
               
               
                 D29810 
                   
                 0.0167239 
                 21738 
                 Hs.173374 
                 Hs.173374 
                 406 
               
               
                   
               
               
                 NM_000059 
                 BRCA2 
                 0.009552 
                 21802 
                 Hs.34012 
                 Hs.34012 
                 407 
               
               
                   
               
               
                 NM_000245 
                 MET 
                 0.0309642 
                 21838 
                 Hs.419124 
                 Hs.316752 
                 408 
               
               
                   
               
               
                 NM_000301 
                 PLG 
                 0.0015124 
                 21854 
                 Hs.143436 
                 Hs.75576 
                 409 
               
               
                   
               
               
                 NM_000527 
                 LDLR 
                 0.0391406 
                 21922 
                 Hs.213289 
                 Hs.213289 
                 410 
               
               
                   
               
               
                 NM_000757 
                 CSF1 
                 0.0412441 
                 21993 
                 Hs.173894 
                 Hs.173894 
                 411 
               
               
                   
               
               
                 NM_001289 
                 CLIC2 
                 0.0360497 
                 22101 
                 Hs.54570 
                 Hs.54570 
                 412 
               
               
                   
               
               
                 NM_001470 
                 GABBR1 
                 0.0510091 
                 22129 
                 Hs.167017 
                 Hs.167017 
                 413 
               
               
                   
               
               
                 NM_001798 
                 CDK2 
                 0.0144224 
                 22188 
                 Hs.19192 
                 Hs.19192 
                 414 
               
               
                   
               
               
                 NM_002167 
                 ID3 
                 0.0491659 
                 22261 
                 Hs.76884 
                 Hs.76884 
                 415 
               
               
                   
               
               
                 NM_002231 
                 KAI1 
                 0.0386124 
                 22277 
                 Hs.323949 
                 Hs.323949 
                 416 
               
               
                   
               
               
                 NM_002385 
                 MBP 
                 −0.0155256 
                 22317 
                 Hs.408543 
                 Hs.69547 
                 417 
               
               
                   
               
               
                 NM_002673 
                 PLXNB1 
                 0.0308982 
                 22375 
                 Hs.278311 
                 Hs.278311 
                 418 
               
               
                   
               
               
                 NM_002912 
                 REV3L 
                 −0.0246321 
                 22408 
                 Hs.232021 
                 Hs.115521 
                 419 
               
               
                   
               
               
                 NM_003174 
                 SVIL 
                 0.0029477 
                 22460 
                 Hs.163111 
                 Hs.154567 
                 420 
               
               
                   
               
               
                 NM_003443 
                 ZNF151 
                 0.0011354 
                 22501 
                 Hs.433764 
                 Hs.33532 
                 421 
               
               
                   
               
               
                 NM_003632 
                 CNTNAP1 
                 −0.0127668 
                 22533 
                 Hs.408730 
                 Hs.31622 
                 422 
               
               
                   
               
               
                 NM_003809 
                 TNFSF12 
                 0.0254481 
                 22560 
                 # N/A 
                 Hs.26401 
                 423 
               
               
                   
               
               
                 NM_004655 
                 AXIN2 
                 −0.0110348 
                 22720 
                 Hs.127337 
                 Hs.127337 
                 424 
               
               
                   
               
               
                 NM_004760 
                 STK17A 
                 0.009661 
                 22741 
                 Hs.9075 
                 Hs.9075 
                 425 
               
               
                   
               
               
                 NM_004937 
                 CTNS 
                 0.0419382 
                 22775 
                 Hs.187667 
                 Hs.64837 
                 426 
               
               
                   
               
               
                 NM_005451 
                 ENIGMA 
                 −0.0025827 
                 22920 
                 Hs.436339 
                 Hs.102948 
                 427 
               
               
                   
               
               
                 NM_006021 
                 DLEU2 
                 0.0449619 
                 23033 
                 Hs.446406 
                 Hs.43628 
                 428 
               
               
                   
               
               
                 NM_006328 
                 SIP 
                 0.0340722 
                 23099 
                 Hs.11170 
                 Hs.11170 
                 429 
               
               
                   
               
               
                 NM_006271 
                 CRTAP 
                 −8.15E−04 
                 23107 
                 Hs.511747 
                 Hs.155481 
                 430 
               
               
                   
               
               
                 NM_006459 
                 KEO4 
                 −0.0177744 
                 23123 
                 Hs.285818 
                 Hs.285818 
                 431 
               
               
                   
               
               
                 NM_006541 
                 TXNL2 
                 0.0361709 
                 23143 
                 Hs.42644 
                 Hs.42644 
                 432 
               
               
                   
               
               
                 NM_007086 
                 AND-1 
                 −0.0039346 
                 23247 
                 Hs.385998 
                 Hs.72160 
                 433 
               
               
                   
               
               
                 NM_012301 
                 KIAA0705 
                 0.0137393 
                 23338 
                 Hs.22599 
                 Hs.22599 
                 434 
               
               
                   
               
               
                 NM_013402 
                 FADS1 
                 0.029603 
                 23404 
                 Hs.503546 
                 Hs.132898 
                 435 
               
               
                   
               
               
                 NM_014813 
                 KIAA0806 
                 0.0174454 
                 23600 
                 # N/A 
                 Hs.24279 
                 436 
               
               
                   
               
               
                 NM_016336 
                 HSU93243 
                 0.0247606 
                 23760 
                 Hs.184325 
                 Hs.184325 
                 437 
               
               
                   
               
               
                 NM_018155 
                 FLJ10618 
                 −6.22E−04 
                 23968 
                 Hs.144130 
                 Hs.42484 
                 438 
               
               
                   
               
               
                 NM_018283 
                 FLJ10956 
                 0.0728296 
                 23990 
                 Hs.144407 
                 Hs.144407 
                 439 
               
               
                   
               
               
                 NM_018677 
                 LOC55902 
                 0.0176673 
                 24113 
                 Hs.14779 
                 Hs.14779 
                 440 
               
               
                   
               
               
                 NM_020524 
                 HPIP 
                 0.0115252 
                 24250 
                 Hs.505806 
                 Hs.8068 
                 441 
               
               
                   
               
               
                 U00952 
                 HPIP 
                 0.0333791 
                 24362 
                 Hs.505806 
                 Hs.8068 
                 442 
               
               
                   
               
            
           
           
               
               
            
               
                 UniqID 
                 Oligo Probe Sequence 
               
               
                   
               
               
                 NM_001615 
                 CAAGGATCCCCTCGAGACTACTCTGTTACCAGTCATGAAACATTAAAACCTACAAGCCTT 
               
               
                   
               
               
                 NM_001647 
                 CCCCCCATAAAGACAAACCAATCAACCACGACAAAGGAAGTTGACCTAAACATGTAACCA 
               
               
                   
               
               
                 NM_004265 
                 ACCCATAGGGAGCTGATCGTAATGTTTATCATGTTACTTCCCCACCCCTACATTTTTTGA 
               
               
                   
               
               
                 NM_001710 
                 CCCCTTGATAGTTCACAAGAGAAGTCGTTTCATTCAAGTTGGTGTAATCAGCTGGGGAGT 
               
               
                   
               
               
                 NM_014585 
                 ACGTAAAAGAGTGGTTAGTCACGTGAATTCAGTTATCATTTGACAGATTCTTATCTGTAC 
               
               
                   
               
               
                 NM_002345 
                 AAATAGGTGGTAGATATTGAGGCCAAGAATATTGCAAAATACATGAAGCTTCATGCACTT 
               
               
                   
               
               
                 AL133644 
                 ACTGAAGAAGGGATGTCCGCTATATCCAAAATTACAGCTATTGGCAAATAAACGAGATGG 
               
               
                   
               
               
                 AF113007 
                 GCTTGGTAATAAGAAGCACTTAAATCACTCCAAAGAAGACTTTAAAAAGGGAGCAGTGAA 
               
               
                   
               
               
                 NM_003878 
                 CAGATGGCAAGATTGAGTTTATTTCAACAATGGAAGGATATAAGTATCCAGTATATGGTG 
               
               
                   
               
               
                 Contig34896_RC 
                 CTGGCTCATAGCATTTCACAAACATTATACTTCAGAGTCCCAAAGCCTTTAAATAAAATG 
               
               
                   
               
               
                 D25328 
                 TATTTTATCAGCACTTTATGCACGTATTATTGACATTAATACCTAATCGGCGAGTGCCCA 
               
               
                   
               
               
                 NM_002318 
                 GAGCACCATGTGTCATCACAGACACTTACACATACTTGAAACTTGGAATAAAAGAAAGAT 
               
               
                   
               
               
                 NM_020372 
                 TTGCTCTATCATTCTGTTTCAATAAAGACATTTGGAATAAACGAGCATATCATAGCCTGG 
               
               
                   
               
               
                 AL137274 
                 GGTACATTACTGCAATGTTCTCTTAACAGTTAAACAAGCTGTTTACAGTTTAAACTGCTG 
               
               
                   
               
               
                 Contig56705_RC 
                 CAGCAACCTCAGACCAACCCAAGAAGATAATTTAAATCTATACTGCTTATTGGTCAATAT 
               
               
                   
               
               
                 Contig54295_RC 
                 GTCACTCTACATGAATTATGTGCTCAAATTTGACCAACTCAGTTTAAGACACAAAACAGT 
               
               
                   
               
               
                 NM_000210 
                 GGAGGGTGGTCAACAAAGAAACAAAGATGTTATGGTGTTTAGACTTATGGTTGTTAAAAA 
               
               
                   
               
               
                 Contig57062_RC 
                 GGCAGTTTACAGAACTCAATGACTTGTCATGAGGTTTTCATATGAGCTACACATTGTGTA 
               
               
                   
               
               
                 U95006 
                 TCCCCAGGCTATAAATTTGTTCTCACAAAGCAACATCAATAAATCAAAACTGTCTCTCCC 
               
               
                   
               
               
                 NM_005063 
                 AATAATGCTACCAGGATGCTAAAGATGATGATGTTAACCCATTCCAGTACAGTATTCTTT 
               
               
                   
               
               
                 NM_006074 
                 GAAAGAGAAACTTGTCAACTCATATCCACGTTATCTAGCAAAGTCATAAGAATCTATCAC 
               
               
                   
               
               
                 NM_004585 
                 TCATCAGTTCTGCGAAGGAGATGGTTGGTCAGAAGATGAAGTACAGTATTGTGAGCAGGA 
               
               
                   
               
               
                 NM_003129 
                 GTTGCAATCTATGCCGTGTATTTTTGCTTTAAGTCAGAACCTTGGATTACAAAACCTCGA 
               
               
                   
               
               
                 NM_016348 
                 ATCAAACAAAATCCTTGAGGTTGGTATACAAGTTAAGGCTGAAAAAAGGCCTTAAATTCC 
               
               
                   
               
               
                 AL133074 
                 TTTTTATACTGATTGGTTCATAGATGGTCAGTTTTGTACACAGACTGAACAATACAGCAC 
               
               
                   
               
               
                 NM_000076 
                 GTATTAATAACGTCTTTTTATATCTAAATGTATTCTGCACGAGAAGGTACACTGGTCCCA 
               
               
                   
               
               
                 NM_001993 
                 TGTAGGAAAGTAAAATGGAAGGAAATTGGGTGCATTTCTAGGACTTTTCTAACATATGTC 
               
               
                   
               
               
                 NM_003379 
                 TATGCATGTAATGGACTATGCACACTTTTAATTTTGTCAGATTCACACATGCCACTATGA 
               
               
                   
               
               
                 NM_000784 
                 CTAAAAGGCCACCCCTTTATCGCATTGCTGTCCTTGGGTAGAATATAAAATAAAGGGACT 
               
               
                   
               
               
                 X59405 
                 TTTATACCCGTTTCACATGCTTTTCAAGAATGTCGCAATTACTAAGAAGCAGATAATGGT 
               
               
                   
               
               
                 M55914 
                 GTACCGCTTCCTTAGAACTCTACAGAAGCCAAGCTCCCTGGAAGCCCTGTTGGCAGCTCT 
               
               
                   
               
               
                 NM_005694 
                 ATGGTGGTCTGCTGTGTGAATAAATAATTCCTGAAGAATGAAGAAGATTAATTTTGGGAG 
               
               
                   
               
               
                 Contig47563_RC 
                 AGCAAACAATTAGCTGAAAACTTGGTATTGTTGTAGTTTATGTAGTAAGTGACTTGGCAC 
               
               
                   
               
               
                 AB040884 
                 GCACACTGTCAAATTCTTTTCCTTAAGGTGCACAGTAAATGTACAGATAGTTATAGGCCA 
               
               
                   
               
               
                 AF035284 
                 CAAAAAGACATGGAAGGTTAGGTTTGTCAACAGAAAGACATGGAAGATTAGAGGTTTGTC 
               
               
                   
               
               
                 NM_016423 
                 TTGGTACGATTCCTGTCATCCCTATTGCAGAGTCGTGTCCCCAATAAACAGGTGTCTTAA 
               
               
                   
               
               
                 NM_000484 
                 TTGGGTCTTTGATAAAGAAAAGAATCCCTGTTCATTGTAAGCACTTTTACGGGGCGGGTG 
               
               
                   
               
               
                 NM_001386 
                 ATTCCTTAAGAACTCTGTGTTATATTACCATGGAACGCCTAATAAAGCAAAATGTGGTTG 
               
               
                   
               
               
                 NM_003090 
                 TAATAGCCTTGTTTGTGTTAGCAAAGTGGAATCTATCAGCATTGTTGAAATGCTTAAGAC 
               
               
                   
               
               
                 NM_016058 
                 CACAAGAAGAAAGTATCGGGACATTATTGGATGCTATCATTTGTAGAATGTCAACAAAAG 
               
               
                   
               
               
                 NM_003255 
                 AGCTCTGACATCCCTTCCTGGAAACAGCATGAATAAAACACTCATCCCATGGGTCCAAAT 
               
               
                   
               
               
                 NM_005648 
                 TGTGCTATCGAAAGTATGCATGTATTTTACGTACAAGGTTCGCTACACTAACAGCTCCAC 
               
               
                   
               
               
                 AL050002 
                 CCGAGATATCTGTTTTGCAACAAGATGGGCTATATCTAAATAAAGACATGATCAAAGGAA 
               
               
                   
               
               
                 NM_000214 
                 GCTATTACGAAGTTCAAGATCAAAAAGGCTTATAAAACAGAGTAATCTTGTTGGTTCACC 
               
               
                   
               
               
                 AB029018 
                 GTGTTTCATATGCGTGACCGTTAAGATATTATCATTTAGGTGAAGGTTTCAACTCAAAAC 
               
               
                   
               
               
                 Contig37878_RC 
                 AGACCTAACTGTTACCATCTGACTGAGGTTACTCTGGTATTTATCTCTTCGCTGCTGAAA 
               
               
                   
               
               
                 D43950 
                 TCTCTTGCAACACAAATGGTTAGAATGATTTTGAAGATTGATGACATTCGTAAGCCTGGA 
               
               
                   
               
               
                 NM_000366 
                 CGGAGAGGTCAGTAACTAAATTGGAGAAAAGCATTGATGACTTAGAAGACGAGCTGTACG 
               
               
                   
               
               
                 NM_004126 
                 AAGGAGACTTTCTTAAGCACCATATAGATAGGGTTATGTATAAAAGCATATGTGCTACTC 
               
               
                   
               
               
                 Contig2930_RC 
                 ATGTGCTAAACTGGAGGTAACTATTTCTAGGTAGTTGAATTTTTGAAAGTCATGATCAGC 
               
               
                   
               
               
                 NM_000235 
                 TATAATTACTTTAGCTGCACTAACAGTACAATGCTTGTTAATGGTTAATATAGGCAGGGC 
               
               
                   
               
               
                 NM_001428 
                 AGCTCTAGCTTTTGCAGTCGTGTAATGGGCCCAAGTCATTGTTTTTCTCGCCTCACTTTC 
               
               
                   
               
               
                 NM_003670 
                 GACTCAGTTTTCAATTCCATCCTAAAACTCCTTTTAACCAAGCTTAGCTTCTCAAAGGCC 
               
               
                   
               
               
                 AK000060 
                 GAGAGAGAAAACATACCCACAGATAAAGACTCAGAATTTACTTCTTTGGGTATGAGTGCC 
               
               
                   
               
               
                 NM_003094 
                 GCGGATAGAAGGCTGTATCATTGGTTTTGATGAGTATATGAACCTTGTATTAGATGATGC 
               
               
                   
               
               
                 NM_002997 
                 TAGGAGAACCAAATCTGGAAGCCAAAATGTAGGCTTAGTTTGTGTGTTGTCTCTTGAGTT 
               
               
                   
               
               
                 NM_006813 
                 CAAGGTGAAGATCTAAATGTGAACAGTTTACTAATGCACTACTGAAGTTTAAATCTGTGG 
               
               
                   
               
               
                 NM_012385 
                 GCAGCAACAATAAATAGACACGCACGGCAGCCACAGCTTGGGTGTGTGTTCATCCTTGTT 
               
               
                   
               
               
                 NM_002444 
                 GCATTGCTGTGAATTAGCTCACTTGGTGATATGTCCTATATTGGCTAAATTGAAACCTGG 
               
               
                   
               
               
                 U82987 
                 GATGGCCCAGCCTGTAAGATACTGTATATGCGCTGCTGTAGATACCGGAATGAATTTTCT 
               
               
                   
               
               
                 AB007916 
                 GCAGCCGTGGTAGTAGCTGTCTATGATTCTTGCTCAGCAAAGTAAAATAAATGTTAAATA 
               
               
                   
               
               
                 NM_003289 
                 CAGAGGAGGAGTATTCCACCAAAGAAGATAAATATGAAGAGGAGATCAAACTGTTGGAGG 
               
               
                   
               
               
                 NM_004911 
                 ATAATTCTCTGTACAGGGGGGTTTGTGCTATACACTGGGATGTCTAATTGCAGCAATAAA 
               
               
                   
               
               
                 NM_000877 
                 AGGAAGAAGACACATTCCTAGTTCCCCGTGAACTTCCTTTGACTTATTGTCCCCACTAAA 
               
               
                   
               
               
                 NM_006519 
                 TTCATTTCAAAGGTGCTAAAATCTGAAATCTGCTAGTGTGAAACTTGCTCTACTCTCTGA 
               
               
                   
               
               
                 Contig57494_RC 
                 TGCGCAGCACTTAACCAGTCGTTTGTATTCCCTTTCTTTCAATCCAATAAACAGAATGAA 
               
               
                   
               
               
                 NM_000269 
                 GTCTGAAATTCATGCAAGCTTCCGAAGATCTTCTCAAGGAACACTACGTTGACCTGAAGG 
               
               
                   
               
               
                 NM_018048 
                 GAAAATACATTAGCAAGCTTAATGGTTATCCTTACTTGAGTCCACATGGGTTGGACAGTC 
               
               
                   
               
               
                 Contig3607_RC 
                 AAGCTGTGCTGTTTAGAAACAACATCTCAGACTTTACAAAGAAATGACAAAGAAGGCAAT 
               
               
                   
               
               
                 NM_006022 
                 ACCCCTTTTAAGAATTTGGCACAGTTACTCACTTTGTGTAATCTGAAATCTAGCTGCTGA 
               
               
                   
               
               
                 Contig3820_RC 
                 CTGGTTACGAAGAAAACTCACCAATCATCTCCTTCCTGTTAATCACATGTTAATGAAAAT 
               
               
                   
               
               
                 Contig3695_RC 
                 ATACCTCATTCTGACACCTGCATATAGTGTGGGAAATTGCTCTGCATTTGACTTAATTAA 
               
               
                   
               
               
                 NM_003186 
                 CCGTGGAGATCCCAACTGGTTTATGAAGAAAGCGCAGGAGCATAAGAGGGAATTCACAGA 
               
               
                   
               
               
                 Contig48249_RC 
                 AGACGTGCCTTTAAGCAATAAAAATTCCAAGAGCTGATCATTATTGTGCTTCCATTTTAG 
               
               
                   
               
               
                 AK001362 
                 GAAACATCATGTCACATGAAACGATTCTCTGCTTTTTGGTTCTGAACTTGAAGTCCCTAA 
               
               
                   
               
               
                 NM_000222 
                 TTGACTTCAATGATAGTAAGAAAAGTGGTTGTTAGTTATAGATGTCTAGGTACTTCAGGG 
               
               
                   
               
               
                 NM_004107 
                 TCTGCCTCAGTTTCCCCTCCTAATACATATGGCTGTTTTCCACCTCGATAATATAACACG 
               
               
                   
               
               
                 NM_018455 
                 CCGACAAGAGGAGATCATTTTAGATATTACCGAAATGAAGAAAGCTTGCAATTAGTGAAC 
               
               
                   
               
               
                 AL049471 
                 GATTCCAGCTATGTAACCTCTATGCTCTGTAAGGTGATTATTTGTATATAGCAACATGGC 
               
               
                   
               
               
                 NM_000177 
                 ATCCAAAAATAGCCCTGCAAAAATTCAGAGTCCTTGCAAAATTGTCTAAAATGTCAGTGT 
               
               
                   
               
               
                 NM_001948 
                 GAGGTTTTGGTTCCACTGGAAAGAATTAAAATTTATGCCAAGAACAGAAAACAAGAAGTC 
               
               
                   
               
               
                 590469 
                 GTGATTTCCAGTGAGTGTAAATAATTTTAAATAACCTCTGGCCCTTGGAATAAAGTTCTG 
               
               
                   
               
               
                 NM_014463 
                 TTCCACTCCTGAAATGAGTTGATTTGCAGATAACTCACAACTTCTTAAGCTAAATGGTAT 
               
               
                   
               
               
                 NM_016824 
                 ATTTTTGGAGTCCCATTGTTTCAGTGGGCATTAACAGAATGCTTTAAAAACTTCTAAGAC 
               
               
                   
               
               
                 NM_002106 
                 CGAGTCTTAACCATATTTAAGTGTTACTGTGGCTTCAAAGAAGCTATTGATTCTGAAGTA 
               
               
                   
               
               
                 Contig52945_RC 
                 GGCAATCATTTTCAGACCACTATGTGTTTGAATCCTCTGGTATCAATACGTATTATAGGG 
               
               
                   
               
               
                 NM_001070 
                 GCCTGCAAACACATTTACTTCTCCTCTTATGAGACTATTTATCTTTAATAAAGCACTGGG 
               
               
                   
               
               
                 NM_006807 
                 GAGTCATGAGAACCATCAGTTCTTGATATTGTCTAGACTTGCATCTAGAGCTACGTTGTA 
               
               
                   
               
               
                 NM_002950 
                 AAGGAATTTTCAATATTTGATTGGTATTCTGTTCTGAAGTCTAGGATATTTTTCAGCCTA 
               
               
                   
               
               
                 NM_002792 
                 TATACTGACGAAGCCATTGAAACAGATGATCTGACCATTAAGCTGGTGATCAAGGCACTC 
               
               
                   
               
               
                 NM_004595 
                 ATTTTACACTGTTTGGAAGAAAGCTAAACCCTGAAGATCAGTAGCCCCTAATCACATGTG 
               
               
                   
               
               
                 NM_006745 
                 GAATTCACCTAAAGATCAAAATATCATGGATTGAACCTCATCAATTGATAGCAGTGAGTG 
               
               
                   
               
               
                 Contig1998_RC 
                 TAAAAGTAACCATTGGAAACCTCGAATGAGGGCTAAAGTTTTAATCATAAGAGAAAAGGC 
               
               
                   
               
               
                 NM_002816 
                 AAATGTGGAGAAGATAACACTTGATTCCATTTCATTGTCATTAGTGTATTAACCAGCAGG 
               
               
                   
               
               
                 NM_006291 
                 GATATTGTTAATATAATAATAATTATTTTTTAGAGTACTGCTTTTGTATGTATGTTGAAC 
               
               
                   
               
               
                 NM_005962 
                 TGCAGCATTTGATAATGATAAAACACCTCACACCTCACTCTTTATAGTGCACAAAATGAA 
               
               
                   
               
               
                 AF052159 
                 GTTGGCATTGATATGGTACAACCTGCAAATTACTTGCAGTTCTGAGTTTCAGATAAAACA 
               
               
                   
               
               
                 NM_012412 
                 GTAATGCTTCTAAGGATCTCAAAGTAAAGCGTATCACTCCGCGTCACTTGCAGCTTGCAA 
               
               
                   
               
               
                 NM_016951 
                 ATTCATGCTCATCGTATCTGTGTTGGCACTGATACCAGAAACCACAACATTGACAGTTGG 
               
               
                   
               
               
                 NM_018639 
                 TGAACAGTTGCAAAGATGTCTTAATTGTGTAAAGAATTGGTGTAGTCATGACTTTAGCTG 
               
               
                   
               
               
                 NM_002166 
                 CAAAGCACTGTGTGGCTGAATAAGCGGTGTTCATGATTTCTTTTATTCTTTGCACAACAA 
               
               
                   
               
               
                 NM_006114 
                 CATCTCCTCGGTATAAATCATGTTTATAAGTTATGGAAGAACCGGGACATTTTACAGAAA 
               
               
                   
               
               
                 Contig58471_RC 
                 TGGGCACTGTGGTTTTATTTCCTAATTGATTTAAGAAATAAACCTGAAGACCGTCTGGTG 
               
               
                   
               
               
                 NM_004457 
                 TTACCACCTATGACTGTACTTGTCAGTATGAGAATTTTTCTGAATCATATTGGGGAAGCA 
               
               
                   
               
               
                 AK002174 
                 GTTTTGCCACAGTTAACCCATTGTGCTTCTTTGTAATCAAACAGTTTGTGGGAGAATGGG 
               
               
                   
               
               
                 Contig2652_RC 
                 GAGAACTAGATAGCATTGAAGCTGAACTTACAAGAAGAGTAGACATGATGGAACTGTGAC 
               
               
                   
               
               
                 Contig56768_RC 
                 CATCTCATTGTACAGTGTTTTAGTTGCAAGCAGAAAGTAGAATTTGGTATAAAGCAGGTT 
               
               
                   
               
               
                 NM_007043 
                 GAGACAAGAGGAAAGAAACAAAGCATTTATTCCACCTAAGGAAAAACCAATTGTGAAACC 
               
               
                   
               
               
                 AF052100 
                 CCTTTGTGTTAATATCAGAAGTGTATTTGTAGCCCCTCCATAGTGAACAATGAAATAAAC 
               
               
                   
               
               
                 NM_000791 
                 AAACCCATGAAGGTAACTAACGGAAGGAAAAACTAAGAGAATGAAAAGTATTTGCCTCTG 
               
               
                   
               
               
                 NM_001424 
                 ATATGTACCAACAACACGAATTGCACAGTCATCAATGACAGCTTTCAAGAGTACTCCACG 
               
               
                   
               
               
                 U47101 
                 TGATTTGGGGGGAAATTACCAGTAGAATGCCTTGGTCTGAATATTTGATAGAACCAATTG 
               
               
                   
               
               
                 Contig4574_RC 
                 ACAGACACCAGATTTGTGAATAAAGTTGGGGAATGGACAGCCTAACTGGGACATTGCAGT 
               
               
                   
               
               
                 NM_014018 
                 TGTGGAGAATGATCTGTACATAGATTTTGGTGGAAAGTTTCATTGTGTATGTAGAAGACC 
               
               
                   
               
               
                 Contig1505_RC 
                 CTGAAACAGAAATGAAACTGTCCTTTTGACAACTCTCTTATATAATAAAGTATCACCGGC 
               
               
                   
               
               
                 Contig45316_RC 
                 TCATACAATTTAATTGCTCAACCATGCATTTAAAACTCCTCAAGAAAGGATTGGTACTGC 
               
               
                   
               
               
                 NM_018281 
                 GCCAGATTGCCTTCATCATTTCACCTCTCCAGACTTCCATTTCTTCACAAGGATGATGAT 
               
               
                   
               
               
                 NM_003944 
                 ATGCTGCAGGTTGATGTAGACACAGTAAAAGGAGGGCTGAAGTTGAACCCCAACTGCCTG 
               
               
                   
               
               
                 NM_017455 
                 CTGTGACTTTAATAAGCTGGAACAGTCCACTGAATGGGTATAATGAATTGCAGTATATAC 
               
               
                   
               
               
                 AB029032 
                 AGGTTCTGTCAGTTCTTATCAAAAAGCTCGGTACTGCACTACAGGATGAAAAGGAAAAGA 
               
               
                   
               
               
                 Contig37141_RC 
                 CTTTGCTTTGATTGAAGGCTGTAGAGCTGAGTTACCAAAATTTCTATTTCAAAGGAAACC 
               
               
                   
               
               
                 NM_004906 
                 GAGAATCAAATAATAGATGTCCGTACAAGTAGCGCATATATTTAACCATTTAGTTTGGGG 
               
               
                   
               
               
                 NM_005167 
                 GTCACACACCAGCACTTTATACACTTCTGGCTCACAGGAAAGTGTCTGCAGTAGGGACCC 
               
               
                   
               
               
                 Contig50396_RC 
                 AGTATAATCTGCTTTACAACTAGTATAGACCTAAGGTCATTTGCTTTCAATTAGAGGCTC 
               
               
                   
               
               
                 NM_003793 
                 GCAAGAACTCTGGGCTTGGGTAATGAGCAGGAAGAAAATTTTCTGATCTTAAGCCCAGCT 
               
               
                   
               
               
                 NM_006347 
                 AAGAGACCATGGAAGTGTCAGAGATTCAGAATCCAAGATTGTCTTTAAGTTTTCAACTGT 
               
               
                   
               
               
                 AB033034 
                 CCATGAGTAACTCTGACAGGTATTTTAGATCATGATCTCAACAATATTCTTCCAAAATGG 
               
               
                   
               
               
                 NM_001706 
                 GGCAGACACGGATCTGAGAATCTTTATTGAGAAAGAGCACTTAAGAGAATATTTTAAGTA 
               
               
                   
               
               
                 NM_016217 
                 AGACAGATATGTACCTTATTAGAGCACCAGAACTAATTTGCTAAGTCTTTTGTTTAGTCC 
               
               
                   
               
               
                 AL049949 
                 TAGACTTGAATCTACTCTAAACGAATATTTAATCCAACCTCACTACATTGTAGCTCAGTC 
               
               
                   
               
               
                 NM_001482 
                 ACATACACAGATCCTAAGTAGAACCAGGTAATTGTCTCTTTTTCTAATAAGGAATTTGGG 
               
               
                   
               
               
                 NM_001551 
                 TAAAGTGTCAAGTGATTAAGTGTGTATTTGTACCCTAGATGATATGAACCAGCAGTCTTG 
               
               
                   
               
               
                 NM_005360 
                 GCATCGTGTACTTACCAGTGTGTTCACAAAATGAAATTTGTGTGAGAGCTGTACATTAAA 
               
               
                   
               
               
                 NM_014454 
                 CCTAAATGAAAGTGTGTAAATTATAAGAAGCTGGCGATCTTTTGATATGCTGTTTCACAG 
               
               
                   
               
               
                 Contig52737_RC 
                 ACCATGTAAAATGTTGTAGAGATAGAGCCATATAACGTCACGTTTCAAAACTAGCTCTAC 
               
               
                   
               
               
                 NM_006303 
                 GAGTCAGAGTCTTTTTATTTAGGCCAGTTGTCAAGTGTCAATAAAAGCGCATCATGTAAT 
               
               
                   
               
               
                 NM_012428 
                 ACTGGTTGATGATAGATTTTATAACCTAACGGTTCTCATGCGGTGCGTAATTGTAGATGC 
               
               
                   
               
               
                 NM_016103 
                 CGTTCAGGCTTACTCAGAGATTTGATTGCTCAACATGCATAACTTGAATTCAATAGACTT 
               
               
                   
               
               
                 NM_016065 
                 ATGCAGAAGCTACAGATACAGAGGCTACAGAAACATAAATGAGCTGACTTTAGTGAGCAT 
               
               
                   
               
               
                 NM_020188 
                 CTGGGTTGATACCTGAAAGAATCCTGTCTTATTTGGTCTCCATAATCCTTTGAATGGAAA 
               
               
                   
               
               
                 NM_002185 
                 CACTACACAGTCTGCAAGATTCTGAAACATTGCTTTGACCACTCTTCCTGAGTTCAGTGG 
               
               
                   
               
               
                 NM_000099 
                 CATGACCAGCCACATCTGAAAAGGAAAGCATTCTGCTCTTTCCAGATCTACGCTGTGCCT 
               
               
                   
               
               
                 NM_001152 
                 GTGAACAGGCATGTTGTATTCTATAACACAATCTTGAGCATTCTTGACAGACTCCTGGCT 
               
               
                   
               
               
                 NM_014669 
                 TTGACGAGTATCATAGTGGTCATATTGATAGAGCTTTTGATATCATTGAGCGCTTGAAGC 
               
               
                   
               
               
                 NM_003093 
                 ATATTACCTGTTCTGCTTCACCAGGAGATCATGCTGCTGTGATACTGAGTTTTCTAAACA 
               
               
                   
               
               
                 NM_003115 
                 GCCAACCATTTCTTCACTGTACCATTTCTGAGAGATGTTGTCAATGTTTATGAACCTCAG 
               
               
                   
               
               
                 NM_012333 
                 GCTGAGATGAGAAGAGGAATGAGCCATATATTGGGGAAAATCATAGTTTGTAGGTATAAT 
               
               
                   
               
               
                 NM_014909 
                 CACTTTCACACTTCATCTCATTCCTGTTGTCACTTTCCCCGAAACGAATAAAGTCTCCCC 
               
               
                   
               
               
                 NM_019903 
                 GAAGTATTATTATAATTCACCATAAACAGCTATCTGTCTGAATTACTTCAGGCCTTCTCC 
               
               
                   
               
               
                 NM_001286 
                 TATTTGAACCTTTGGAACTTGGGAGTTCTCATTGTAACCCTAACATGTGAGAATAAAATG 
               
               
                   
               
               
                 NM_018287 
                 GCAAATCACTGTAATGAGAATGGTACTGGAAAAATACTGAATAGACTTGCTAAATGGCAC 
               
               
                   
               
               
                 AL133555 
                 TAGCCCATTGCCAAAAGGTTTTACTGTCTTAAAGCTGTCTTTCTGAGATCTAATTCCAAG 
               
               
                   
               
               
                 NM_004508 
                 CTTGTAAATAGTATTTACCAGTTAGCAAAGTCTGTGTTTTCAGAATTACAGTGAGCACAG 
               
               
                   
               
               
                 NM_000062 
                 GTGACGACCAGCCAGGATATGCTCTCAATCATGGAGAAATTGGAATTCTTCGATTTTTCT 
               
               
                   
               
               
                 NM_000373 
                 AAGAATGGGTTCTGGAGTTCTCATGGTCTTTAGGAAATATTGAGTAATTTGTAATCACCG 
               
               
                   
               
               
                 NM_021199 
                 TTCTGTAATTATGAAGAATCAAACACCAACAAAGAAGTATGATGGCTACACATCATGTCC 
               
               
                   
               
               
                 Contig54898_RC 
                 ACAGAACGCAGGTTTTGGAATGGTCTTAAAAGATGTGAGGGTGTTAATCTAGGAAACTTC 
               
               
                   
               
               
                 NM_000788 
                 TCCAGACGCACTGATCTTTGCAAAGGAGACTTAATTTCAAATCTGTAATTACCATAGATA 
               
               
                   
               
               
                 NM_004301 
                 AAGTATGCGGTTGAAATTGATTGCAAATAATACAACAGTGGAACGGAGGTTTAGCTCATG 
               
               
                   
               
               
                 NM_004593 
                 TTGTCGGCTTTTATGTAATCTGTAATATGTATAGCAGGAAATACGAAGAGTTACACAGTG 
               
               
                   
               
               
                 NM_005517 
                 ATAGACTTAACTCCCTTAAGCCCAGACATCTGTTGAGACCTGACCCCTAGTCATTGGTTA 
               
               
                   
               
               
                 NM_017838 
                 ATTTGTCAACAAAGGAGAAAAAGGGATCATGGTTTTGGCAGGAGACACACTGCCCATTGA 
               
               
                   
               
               
                 NM_018243 
                 CTTGCTTAGTCTCCTTTCAGTATTTGGCAATAAAAGAAAGAAGAAATAGAACAGCTGAAG 
               
               
                   
               
               
                 Contig55612_RC 
                 GTAAGGAACTTGGGTGTTAATAGTTGAGAGCTGTTTAGTAATAACCCAGTTTTCTTGAGG 
               
               
                   
               
               
                 Contig40105 
                 GCAGGAGTAGAAAGATGCTCATAGCACACGCGATATGTATGATAACATATTTTGTTTCAT 
               
               
                   
               
               
                 NM_003091 
                 TTCAGAAAGATCAAGCCAAAGAACTCCAAACAAGCAGAAAGGGAAGAGAAGCGAGTCCTC 
               
               
                   
               
               
                 Contig46583_RC 
                 ATGCATAATAACCCAGTTTGTATCAAAGGGTATCGACTTAAGTGAAATTTCAACATGCTG 
               
               
                   
               
               
                 NM_012321 
                 GTGAAGCCCCTTTTTCTTGCTAAAACCGGCAATTCTCCGGTTAGAAATGTTACTTGGTGT 
               
               
                   
               
               
                 NM_014905 
                 GCAGGGACTGAATGACCTGATGTCAGATTTAGATTCTTCCTGGGGATTACACAGCTATGA 
               
               
                   
               
               
                 NM_016639 
                 CGCTGGCTCACACAAAACAGCTGACACTGACTAAGGAACTGCAGCATTTGCACAGGGGAG 
               
               
                   
               
               
                 Contig52717_RC 
                 AAGTGCAAATGCCTCTTTGAAGCAATTCAGGCTAGGTAAACCGATTTTGCCATTTCAAAA 
               
               
                   
               
               
                 Contig58129_RC 
                 TCATACATGGTATACAGATAGCTCATAATGAAGTCCAGAATCTTACTTTTAAGTGAAGGC 
               
               
                   
               
               
                 AK002107 
                 ACACAGTAGCAAAAGAGAAGATCTCATTTACAAATATCTATGGTGTTTCCTTGTTCTGTG 
               
               
                   
               
               
                 NM_002687 
                 CTTCAGGACTAGAAAGAAGTCACAAATCTTCAAAAGGTGGTAGTAGTAGAGATACAAAAG 
               
               
                   
               
               
                 NM_0028008 
                 CCCCCATTCTGGAAGGTTTTGTTATCTTCGGAAGAACCCCAATTATGATCTCTAAGTGAC 
               
               
                   
               
               
                 NM_014325 
                 TTTGATGACTGTACAACAGGAAGACTTGAAAAATCACGTGGATTCATATTACCACCGCTC 
               
               
                   
               
               
                 AL110212 
                 AGAGTCAGGAATACCATGTAACATGTTGAAGTAGACTAAAGATTAGTTCTTTGGCAATAG 
               
               
                   
               
               
                 NM_003374 
                 TCATATTGAGTAAATGAATGAAATTGTGATTTCCTGAGAATCGAACCTTGGTTCCCTAAC 
               
               
                   
               
               
                 L48692 
                 AAATACTTTACAGTGGTCGGTCACAAGAAACCATCTGAACAATTTCAGTCATTTGAAGCT 
               
               
                   
               
               
                 NM_001745 
                 TAGGGGTTGTAAAGCTACTTTATTAGATATAGAATGGCAGATTCTCTGATTTAAAAGGGC 
               
               
                   
               
               
                 NM_002659 
                 CTGGTAGCCACCGGCACTCACGAACCGAAAAACCAAAGCTATATGGTAAGAGGCTGTGCA 
               
               
                   
               
               
                 U09579 
                 CTTTGATTAGCAGCGGAACAAGGAGTCAGACATTTTAAGATGGTGGCAGTAGAGGCTATG 
               
               
                   
               
               
                 AL050353 
                 GGAAAGCTTGTCTGGGTTCTATACTGTGATCTCATTTGCCTCGACTACGATGGAAACATT 
               
               
                   
               
               
                 NM_003707 
                 ACAGCATTGAGAAAGAGCATGTCGAAGAGATCAGTGAACTTTTCTATGATGCCAAGTCCT 
               
               
                   
               
               
                 NM_006397 
                 CGAGAATCAGGAGGGACTCAGGAAGATCACATCCTACTTCCTCAATGAAGGGTCCCAAGC 
               
               
                   
               
               
                 NM_020143 
                 ATTTATCATTTATCTGAAATCACATGTAGCAGATTGCATAGTCTGTAATCCTCTCAGAGG 
               
               
                   
               
               
                 Contig38493_RC 
                 AGGTGGTGATCTGAATACAGCAGCAGTTTGAAAGTGTTCCGTTTTTAAATAAACAGTATG 
               
               
                   
               
               
                 NM_002137 
                 GAGGATGAGAGCCCAGAGGTAACAGAACAGCTTCAGGTTATCGAAATAACAATGTTAAGG 
               
               
                   
               
               
                 NM_005805 
                 CAAGCCATCTATCCAGGCATTAATTCATGGACTAAACAGACATTATTACTCCATTACTAT 
               
               
                   
               
               
                 NM_014350 
                 AGAAAGGTAACAATCTTCATTCTACAGATGAACTCATTGAAACAATTTAGGGGAATGAGG 
               
               
                   
               
               
                 NM_018087 
                 AGATGGGACAGTAAATGTTCAGCATTCTTGGATCAGAAGAAAACGGACTAATTAGATGCT 
               
               
                   
               
               
                 AF113020 
                 AGATCCAGAACATGGGAAGTTAGGGAAAATGTGTGATTTTGTGTTTTGAATTACTGTCAG 
               
               
                   
               
               
                 AK001163 
                 CAGTGACTACGAGTAGTTCTTTCTCTATTGAATTATTAGGTCCAGAATAGAAGATGTCAT 
               
               
                   
               
               
                 Contig57034_RC 
                 GCAAAAGAGTATTAATCCACTATCTCTAGTGCTTGACTTTAAATCAGTACAGTACCTGTA 
               
               
                   
               
               
                 NM_002431 
                 CGATAAGCCTCATCTGATGGAAGAGAGGAATAAATAATTCACCTATATGTGTTTGAGGTT 
               
               
                   
               
               
                 NM_004461 
                 CAGGGACAGAGGACTGGGTAGCAGGTTCCTTCTGTTGTCCTGTGTGGTGTGTCTACTGTG 
               
               
                   
               
               
                 NM_007107 
                 CAGAGATGCGACCTACTCAATCTGACTTAGTAAAACCATGCTGTAGAATTTTTGTCTTAA 
               
               
                   
               
               
                 U09848 
                 TATGACTTAAACCAACTACAACTTCCCTATAGCTTCTAAGCAGTTTCATCAGCATTACTT 
               
               
                   
               
               
                 NM_020401 
                 CTGCCAATGTTGTGTTTTCTGCTTCATACGATATTGCACAGTACTGGTCAGTATCAGGAA 
               
               
                   
               
               
                 NM_016271 
                 GTCACAGTGCTAAGTTATCTAGTTGGCTACTATTACACCTTAAAAATTGAGTTTACACAC 
               
               
                   
               
               
                 NM_002452 
                 GACGACAGCTACTGGTTTCCACTCCTGCTTCAGAAGAAGAAATTCCACGGGTACTTCAAG 
               
               
                   
               
               
                 NM_018290 
                 AAGGGCCAAATGATTCAAAACATCACAGGTATTTATGTGTTTTACAAAGACCTACATTCC 
               
               
                   
               
               
                 X66087 
                 AAACCAATGATTGTAGCAAACTCATACTGGATCATTTCAGTTACCTTGAACTAATAGCAC 
               
               
                   
               
               
                 Contig20651_RC 
                 GGAGGGAATTGTATTGATACTCCAATACCTAAATTTCACAATACCACTTAGGAAAGCTAT 
               
               
                   
               
               
                 NM_016491 
                 CCCATCATCGATCTTCATGAATGCAATATTTATGATGTGAAAAATGACACAGGATTCCAG 
               
               
                   
               
               
                 D80010 
                 ATTACACTTTCAAAGAGAATTCCCTTTGCAATTTTATGTTTGGATCACCACTGTAAGCAC 
               
               
                   
               
               
                 NM_006618 
                 AATAAGCTTTCTCAGAATGTTGGCAAATCACTTCAATCCTCAAATCAGTCTTCCTTGTGG 
               
               
                   
               
               
                 AB020681 
                 AGAACAGGCTTTTAGAAGATAAAAGCGACAAGAAGGAATCTGGTGAATTTTAGTCATCCC 
               
               
                   
               
               
                 Contig41864_RC 
                 AAATGATGGCCAAAGTATTAGAAAGAAACGAAGAGCCACTGGAGATGGATCTTCTCCTGA 
               
               
                   
               
               
                 NM_002949 
                 GACAAAGTGAAGCTGATCAAGGAAATCAAGAACTACATCCAAGGCATCAACCTCGTCCAG 
               
               
                   
               
               
                 NM_005920 
                 CCACTTCCTTTCTTGTGCTTCGTGTCCTGTTGACGGTTACATTTGTGTATAATTATTATA 
               
               
                   
               
               
                 NM_003089 
                 CAACCTTGGCCACTTGAGTTTGTCCTCCAAGGGTAGGTGTCTCATTTGTTCTGGCCCCTT 
               
               
                   
               
               
                 NM_016134 
                 AAGACGCAGAAATGATGTCAAGAATGGCTTCTCATGGGATCAAAATTGTCATTCAGCTAA 
               
               
                   
               
               
                 NM_016326 
                 AAGGCCACGTGAAGATGCTGCGGCTGGTGTTTGCACTTGTGACAGCAGTATGCTGTCTTG 
               
               
                   
               
               
                 NM_005826 
                 CCCTCCAGATTACTACGGCTATGAAGATTACTATGATGATTACTATGGTTATGATTATCA 
               
               
                   
               
               
                 NM_012417 
                 CTTTTGCATGGGTTGATGAGTGGTATGACATGACAATGGATGAAGTCCGAGAATTTGAAC 
               
               
                   
               
               
                 NM_016567 
                 GGGAACCTTCATGACTGTTGGAATTGCTCTGTCATAATAAGTCAGGGATATTTAGGGGGC 
               
               
                   
               
               
                 D55716 
                 ATGTGAATGAAGCCATCAGGCTAATGGAGATGTCAAAGGACTCTCTTCTAGGAGACAAGG 
               
               
                   
               
               
                 NM_004953 
                 CCTCCCCTGGGGCACAGAGATATATTATATATAAAGTCTTGAAAATTTTGAAATTTGGTG 
               
               
                   
               
               
                 NM_006824 
                 TGATGAATGCTATTAAGAAATATCAGAAAGGCTTCTCTGATAAACTGGATTTCCTTGAGG 
               
               
                   
               
               
                 NM_014413 
                 AGTTGTAGTGAATTGCTACTGAAAGCTATCCCAGGTGATACAGAGCTCTTTGTAAACCGC 
               
               
                   
               
               
                 NM_019555 
                 TACAAGTTTATTTAAAACTGCTTTCTCAAGTCGTTATTGATACAGCAAGTGAACCTGCTG 
               
               
                   
               
               
                 AB033054 
                 TGATAATATATTCTGCACGGTAAGAATTCCTTTTACAGACATTCTTTATCAAGAGGTCGG 
               
               
                   
               
               
                 NM_004095 
                 ATCTATGACCGGAAATTCCTGATGGAGTGTCGGAACTCACCTGTGACCAAAACACCCCCA 
               
               
                   
               
               
                 NM_006833 
                 CCATCACCAAAACGTGCAACACCATGAACCAGTTTGTGAACAAGTTCAATGTCCTCTACG 
               
               
                   
               
               
                 NM_012325 
                 CAGTGATTAACAATGCCAAAAAATGCAAGTAACTAGCCATTGTTCAAATGACAGTGGTGC 
               
               
                   
               
               
                 NM_016183 
                 TTTTTATTTGTCTGTAGACAGGGAACATGATGGGCACTGACCTCCTGTAAAGAATAAAAC 
               
               
                   
               
               
                 A8040969 
                 CCCACAGCAATAAAAGCTTCCCCCTGATATCCATCCCTTTGTAGTTTGAACAAATATATT 
               
               
                   
               
               
                 Contig43506_RC 
                 AGTGAAGAGTGAGTGAAAGGAAGAATTCAGTGAATACATTGATACCTTGATATTATCTGC 
               
               
                   
               
               
                 Contig719_RC 
                 GTTCTTGAGGTAGAAATGTCTACAGTCAGTTGTTTCATCTAGCTTGCATCTTAAAACACA 
               
               
                   
               
               
                 NM_005956 
                 CAGGTGAATGGATTATTCTAAACAGATCACCATCCATCTTCAAGAAGCTACTTTGAAAGT 
               
               
                   
               
               
                 NM_006938 
                 GTGCCTCCTTTATTAAGGGGTTCTTTGAGAATAAAAGAGAAAAGACCTACTTTATTTGAC 
               
               
                   
               
               
                 NM_016310 
                 ACCCGCAAGGTAACAAATCGGAAGTACCCAAAACTGAAAGAAGTGGATGATGTGCTTGGT 
               
               
                   
               
               
                 NM_016546 
                 GCATCAAGAGTCAAGTTGCTATATGGTCAAAGGTTAAATTTATCTCTAAAAAATGGCAGG 
               
               
                   
               
               
                 NM_016607 
                 TCTGGGAATAGAAAGTCACCATGATTTTTTGGTGAAAGTAAAAGTTGGAAAATTCATGGC 
               
               
                   
               
               
                 X69111 
                 GGAGACTAAACCTGGTGCTCAGGAGCGAAGGACTGTGAACTTGTAGCCTGAAGAGCCAGA 
               
               
                   
               
               
                 AF052183 
                 CTGCCCTCTCAGCTTGTGAGACAACACAGGAGCCTTCTATAGTATGTTGATATGCTAGAT 
               
               
                   
               
               
                 AK000685 
                 AAACTTGTGTAGGGAATCCTGACTTTTAAAATGTGAGGGTATTTGGATCTGTGTTGAAAG 
               
               
                   
               
               
                 Contig3902_RC 
                 ATTTTTTAGAAAATACACACTTTTCAGGAGAAACCTGAGCATGATTTTGGATTCTCCACC 
               
               
                   
               
               
                 NM_013300 
                 GGGAGAACATCTGATGTTAACTTGACAGTCTTGTCTCGTGTATTGAATTCGTGCCAAAGG 
               
               
                   
               
               
                 Contig47710_RC 
                 GAGATAACCTAGCTCTTTATATCTTCCCTTTTAAATAGAAACAACTGTCTTGAGAAGCTC 
               
               
                   
               
               
                 NM_002004 
                 GGATCTTGTCAGATTCACTGAAAAGAGGTACAAATCTATTGTCAAGTACAAGACAGCTTT 
               
               
                   
               
               
                 NM_003051 
                 AAATGCTGACAAAAATATTTTCCTAGCATCAGTAGATTTCTGGCATATGTTTCTGCTAGC 
               
               
                   
               
               
                 NM_003064 
                 TTCAAAGCTGGAGTCTGTCCTCCTAAGAAATCTGCCCAGTGCCTTAGATACAAGAAACCT 
               
               
                   
               
               
                 NM_006452 
                 CATCTGCGCATAAAGGACCAGATGAAACTCTGAGGATTAAAGCTGAGTATGAAGGGGATG 
               
               
                   
               
               
                 Contig54752_RC 
                 CACACACACACTTAGTCTTGTAATTTCAGGCCAGAAATTCTCAACACTATTTTGCATCTG 
               
               
                   
               
               
                 M94362 
                 AAGTTATTTATGGCCTGGGAAACAATTTGCATTTGTCCCCAAATACGCTTAGCTGTGTGC 
               
               
                   
               
               
                 Contig49652_RC 
                 CTGAAAGTGATACTCTTGGATGTGATTTTGAATTTCAAGAAAGCATCCATTCTCTATCAC 
               
               
                   
               
               
                 Contig56840_RC 
                 AGCCAAGGACCGATTCCAGGCACTTTCTGTAGCAAATGACTGTGAATTACGACTTCTCTT 
               
               
                   
               
               
                 NM_020185 
                 TGGGCCTTTCTCAGAAGACTGTAATGTACCTGAAGTTTCTGAAATATTGCAAACCCACAG 
               
               
                   
               
               
                 NM_007021 
                 AAAGGAAAAAGTTTCAGACAAGCAATTACCCAGTTTCCTTATCTATAAAATGGGGACATC 
               
               
                   
               
               
                 NM_014264 
                 CTCACCAAATGGTCAAACAACTAGGTATGGAGAAAATGAAAAATTACCAGACTACATCAA 
               
               
                   
               
               
                 AL133577 
                 ACTCGTGATCATTGAGAAAGTGTTTGAAACTTTCTCATGAAGTGTATATATAATGGCGTG 
               
               
                   
               
               
                 NM_003016 
                 CCGATTGCTCCTGTGTAAAGATGCCTTGTCGTGCAGAAACAAATGGCTGTCCAGTTTATT 
               
               
                   
               
               
                 NM_002466 
                 CTTGTCCTGAGGTGTTGAGGGTGTCACGAGCCCATTCTCATGTTTACAGGGGTTGTGGGG 
               
               
                   
               
               
                 NM_006988 
                 GTTATCTCATGAGAGCTGTGATCCTTTAAAGAAACCTAAACATTTCATAGACTTTTGCAC 
               
               
                   
               
               
                 NM_016391 
                 TATCAAGATACCCCAAAACAGATTCGGAGTAAGATCAACGTCTATAAACGCTTTTACCCA 
               
               
                   
               
               
                 NM_017787 
                 TTAAACTGACCACTTGGAAGAAACACCTTGGTATCTGTGGTTTTCTTGCCTTGTCCCTGC 
               
               
                   
               
               
                 NM_017816 
                 CCAGACAATGAAATAACCATCAAAAAGCTAAGGAAAAAGGTTTTAGCTCAGTACTACACA 
               
               
                   
               
               
                 NM_021019 
                 CAACTTTCCCATCTTGTCTCTCTTGGATGATGTTTGCCGTCAGCATTCACCAAAATAAAC 
               
               
                   
               
               
                 NM_002388 
                 TGACCCAAGTCTTTGCCTCTACTCCCTTAACAGTGTTGAATTCAACTGAAGGCGAGGAAT 
               
               
                   
               
               
                 NM_003132 
                 TTTGAGTTCATGAAACAGAATCAGGATGCCTTCGACGTGATCATCACTGACTCCTCAGAC 
               
               
                   
               
               
                 NM_004280 
                 GGCAACATCTGTCTAGTGTTGTCTTCATCAAGAACAGACTATATACTAATTCCCACTAGA 
               
               
                   
               
               
                 AB036063 
                 GCTCCTTTGTAAAAAGTTAAAGATTTGAAAGAGAATCTCATATTCCCGAGGCATTAGGAA 
               
               
                   
               
               
                 Contig20635_RC 
                 GGGAGCATAAAACATCCTTGACAGGTAGAGAGAGTTTTGAATGGCTTTTGTTATTTAAAA 
               
               
                   
               
               
                 Contig51797_RC 
                 AGCTCTTTGCTACTGCTATGGTAAGATATCAAATGAAAAACCTCTGTAAAACATTTCCAG 
               
               
                   
               
               
                 NM_002184 
                 TGAGGAAGATTTTGTTAGACTTAAACAGCAGATTTCAGATCATATTTCACAATCCTGTGG 
               
               
                   
               
               
                 NM_006534 
                 GAGCCAGTTAATTTTAAGAATTTCACACATTTAGCCAATCTTTCTAGATGTCTCTGAAGG 
               
               
                   
               
               
                 NM_016613 
                 GAATACGGTAAAATAAATGACTTTAACCAAGTAGCTATAATGGGACTTAGCACTGTATGC 
               
               
                   
               
               
                 NM_002971 
                 AGTTGGAAAAGGATAATACAGACTGCACTAAATGTTTTCCTCTGTTTTACAAACTGCTTG 
               
               
                   
               
               
                 NM_005785 
                 GTGCTCAGGAATTTGAAAACGCTGCTATACTTACTCTGGTTACTACATTTCTTCCACTCC 
               
               
                   
               
               
                 NM_017768 
                 TTACCCATGATAGGACTTTTGTGATATGGCTAATCTCAGTACACATTTCAACTTAAAACC 
               
               
                   
               
               
                 NM_018381 
                 TAATTCCTTCCCTATCTCCTTACCAAAGTACAAGTCACATCTTTCCCACCTTTTCTGCAA 
               
               
                   
               
               
                 U79458 
                 TTCTGCCTTTTGCTGGTGTTTCTGGAATTTGCTTTCCCTCACCTCTCACTTCCTTCTAGA 
               
               
                   
               
               
                 AF054996 
                 TTCGCAAACCAGGACGACTACATATCATTTCGGCACCATGTGTATAAGAAGACAGACCAC 
               
               
                   
               
               
                 AL079279 
                 CCCTGCTTAAATGGTGGAAAATGTGTAAGACCAAACCGATGTCACTGTCTTTCTTCTTGG 
               
               
                   
               
               
                 Contig24856_RC 
                 TTGCTTTGTCTCCCTGGATATGGATTTCAGTTAAGTATTTTGTAACCCGTTACACTGTGT 
               
               
                   
               
               
                 Contig2493_RC 
                 TTGAGCTGCATTCAGGAAGTGCGGGACATGGTAGGGGAGGCAAAAAGCCTTGGGCACTAC 
               
               
                   
               
               
                 Contig49757_RC 
                 CATGCATTGGATGTTTTGCTAAATAACTCCTGTGGATTTAGGAATGTGTGCTAATAGCAA 
               
               
                   
               
               
                 NM_004596 
                 GCTTTAAGATCACGCAGAACAACGCCATGAAGATCTCCTTTGCCAAGAAGTAGCACCTTT 
               
               
                   
               
               
                 NM_006396 
                 ACGATCCTCCTCCAAGACAAACAGCGGAAAATCTACTGCGTGGCTTGTCAGGAACTCGAC 
               
               
                   
               
               
                 NM_007066 
                 CACCTTCGCACCGTGCCCAGGTACACTTTCAAGACACTGTAACCACAAGATGTTATTTAT 
               
               
                   
               
               
                 AB037784 
                 CAAATGATTCCGGATCTCTAAAAGGCTCTCTCAGATGAAAAGGGAGTAAAGGAAAAAAGA 
               
               
                   
               
               
                 Contig37368_RC 
                 GCAGCTGTAGATACAAAAAGTCCTCTAATGGAGTACTGGAATGTTTCATTGTCTTCACAA 
               
               
                   
               
               
                 NM_005704 
                 ATATTTTGCTCACTATCCCTCCCCACTTGCTTCCCTGATATGTGCTCTGACTTCCCTGAA 
               
               
                   
               
               
                 NM_005796 
                 GTTCCTATTAAAGAACATCAACGATGCTTGGGTTTGCACCAATGACATGTTCAGGCTCGC 
               
               
                   
               
               
                 AB002321 
                 CATTTGGAGACAGAGCCATTTGGATATTTTCCCCTTGAACTTCTCCATGACCTGAAGCGT 
               
               
                   
               
               
                 AF055016 
                 GTGTTACCTCAATTTCAGAGTAAGTAGTGGTTGATTAGTAATGTAGTATACACTGGCAGA 
               
               
                   
               
               
                 Contig48842_RC 
                 AATGACAGGAAGATGTTCTTGTTTGGAACCTACCTGACTAAGAATGGCTCAGAGATACCC 
               
               
                   
               
               
                 NM_001274 
                 GTTGGGCTATCAATGGAAGAAAAGTTGTATGAATCAGGTTACTATATCAACAACTGATAG 
               
               
                   
               
               
                 NM_002692 
                 TGTGCCCGATCTACTTGTCATTGCAGACAAATATGATCCTTTCACTACGACAAATACCGA 
               
               
                   
               
               
                 NM_006444 
                 TGTGGTGTCACTAAAAGAAGGTATGTTCAACAATGCAAACGTTCTTTTCAAAACCAAGTT 
               
               
                   
               
               
                 NM_014977 
                 AGCCAAGGGTCTTTCACATCACCTATCCCTACATACATACCAAATGGAAAAGTGGCCATC 
               
               
                   
               
               
                 NM_016126 
                 CTTGTAATCCAAAGTTACTTTGTACAGACCTTGAAGATTGAAAAAACACGTCTAAAGAGC 
               
               
                   
               
               
                 Contig53132_RC 
                 AGAGGGAAGACATTAAGGGGATTGGGGACATTTGTTTCACACATCTGCAGTAATATGAGT 
               
               
                   
               
               
                 NM_000935 
                 CCTTGAAAATCAGATTCTAACTGATTGTATGCAACTAAGTATTTCTGAACACCTATGCAG 
               
               
                   
               
               
                 M31212 
                 CTTGTCTCTCTTGGATGATGTTTGCCGTCAGCATTCACCAAAATAAACTTGCTCTCTGGG 
               
               
                   
               
               
                 NM_005928 
                 CTCACTGTCCTGTTTTCTTAGGCACTGAGGGATCTGAGTAGGTCTGGGATGGACAGGAAA 
               
               
                   
               
               
                 AK001025 
                 GTACAGGATGGATTATGGAGAATTTGGTAATCTAGTCGGAATAATTATATTGTATTGGGC 
               
               
                   
               
               
                 AL049435 
                 CTAAGTCATACTACTGATGGAATGAGAATACAAACCAAAAACACTTTATTCAAGTCCAGG 
               
               
                   
               
               
                 AL157475 
                 TTCCTTACTTTGCACAGTGAACACAACTAACCACATTAATTCAGCTTTGTGAAGTCCCTG 
               
               
                   
               
               
                 Contig43868_RC 
                 GATTCCTACCTCTCATGATTACTATGGAGATTGAATAATTGGTAAAATTCTCCTAGCTCA 
               
               
                   
               
               
                 NM_002804 
                 TCATCTTCATTGATGAGTTGGATGCCATCGGCACCAAGCGCTTTGACAGTGAGAAGGCTG 
               
               
                   
               
               
                 NM_002915 
                 ATGGAGGATGGATTGGAAGGCATGATGTTCTGACTTCTGTCAGTTATTCTTGCAAAGATT 
               
               
                   
               
               
                 NM_004102 
                 CAAGCCTACCACAATCATCGAAAAGAATGGGGACATTCTCACCCTAAAAACACACAGCAC 
               
               
                   
               
               
                 Contig40852_RC 
                 CATCTGCTTAGCTTAGTTCTACAAACTTTTTCATTTTTAATGTGCAAAGAACAGGCGGGG 
               
               
                   
               
               
                 Contig41097_RC 
                 CAATTGTCAGAGTACAACGTGATGGCAACAAACTCATAGAGTTTAATAATGGCCAAAGAG 
               
               
                   
               
               
                 Contig53180_RC 
                 CCTAATTTTCTCTCCTGGTAGCTGAACAAAGGTCTAAATTAGCTTAACAAAAGAACAGGC 
               
               
                   
               
               
                 D42044 
                 GACAAACTCTCTTACTCCTTAAGACAAATGCTCACCTGATCAATATGGGGAAATAAGCTG 
               
               
                   
               
               
                 NM_006638 
                 GGCATAAAACAGGTTCAGAAGAATCGACAATGATGTCATATTTTTCCAAGTACCAAATTC 
               
               
                   
               
               
                 NM_014060 
                 TATTGAACCATGGCTTAATCAAATCATGCCTAAGAAAGATCCTGTCAAAATAGTCCGATG 
               
               
                   
               
               
                 NM_014891 
                 GGAAAGCAAAAGACGATGGCACATTGTCAGGAAAACGAATGCAGTCACTCTCCCTGAATA 
               
               
                   
               
               
                 NM_018948 
                 CAGAGTTCCCATACCTCCTAGACCAGTAAAGCCAGATTATAGAAGATGGTCAGCAGAAGT 
               
               
                   
               
               
                 Contig51654_RC 
                 CCTAGCTGTCTTCTTGAACTTGGGACTCTCCTTTCCCAAGACTTCCATCACTAGCTCCTG 
               
               
                   
               
               
                 NM_002221 
                 CTCCTTGAAAGCTTTGCCTTTGTTTTGAACTTCCTTTCCCACTTGGTAGAAAGAGCCCAG 
               
               
                   
               
               
                 NM_002461 
                 TGAAGGGCTTTCTCACCCCAGCTCTGGCTATGCCCAGTTCTCTGAGAAAGGAGCTCAGTG 
               
               
                   
               
               
                 NM_002611 
                 ACTGTGGAAAGCCATGAGTCCAGCCTCATTCTCCCACCCATCAAGGTCATGGTGGCCTTG 
               
               
                   
               
               
                 NM_005542 
                 ACCAGACCTAATTTGCAAGTATTGGGTCTTCAAACTTCAAGTGCAATGTATTATGAAAAC 
               
               
                   
               
               
                 NM_005887 
                 CATTCATGCCAAGTATCTTTCCAGCATGTTTCTCCCATTTAGAATATCTAGCATGTAAGG 
               
               
                   
               
               
                 NM_017644 
                 TCCAGTTGAAGATTACTGGATGCACGTACAGAATACATTCAGCCGTCAGGTAATAACATG 
               
               
                   
               
               
                 NM_017955 
                 CTAGGTTGAAGTCTAGAATGAAAGAAATCTGAATCCATGTCATTCATAACCCCTTGATCT 
               
               
                   
               
               
                 NM_017975 
                 ACAAGAACAGGTTTATCGTGTCCAAAAACTCCACCATATTCTAGAAATATTAGTCAGTTG 
               
               
                   
               
               
                 NM_018300 
                 CTCACATTGTACAATATTGCAAAAATTCATGCTTGAGAGAAACAAAAACACTGAGAGTGG 
               
               
                   
               
               
                 NM_019610 
                 AACACCTGTTTTTATTCCCCTGAGATCTAAACCTGTTTATGGAAAAAGATGGTCTAGTTC 
               
               
                   
               
               
                 AB040964 
                 TCTTTTCCCCAACCTAAAACCAACCACCAGCATTTCACTACAGGACCAAATGGAAACCGA 
               
               
                   
               
               
                 Contig3794_RC 
                 GATATGAGCTCCTCATAGAAACCAGACCTACTGTATTAGACAGTAACCTCTAACCTCACC 
               
               
                   
               
               
                 NM_001458 
                 TACAACCCCAGAGTTTTAAGGACTTGGAAAGGAAGCACAATCAGAGAAGAAAACAGCCCC 
               
               
                   
               
               
                 AB037726 
                 GTTGCCCTTAAACCATTTCTAGCTGTTAACCCTATCCAGAAAAATGATTGAGTGATAGCT 
               
               
                   
               
               
                 AF070559 
                 CAGCATAAACTCAGAGATGAAGACCTCTTTCGTTTAAAAGAGCCTGTACTGTTTGTGTCA 
               
               
                   
               
               
                 Contig30070_RC 
                 TGGTATAGCAAGAAGGTATTCTGAGCATTATATCAATGGGGAAGTTATAGATCTTTTGCA 
               
               
                   
               
               
                 Contig36836_RC 
                 CTTCCTAGCAATAGTCTGCATTTAAAGAAAGGTGTGTTCAATTCATCAGCTTGAAATTGA 
               
               
                   
               
               
                 Contig37066_RC 
                 GAGTTTGTCTTCTACGACCAGCTGAAGCAAGTGATGAATGCGTACAGAGTCAAGCCGGCC 
               
               
                   
               
               
                 Contig42355_RC 
                 TCTTTTCTATCTGATCCACATGGAGAGGTTAAAGGTTCAATTTCATGACCTCTATGCAGG 
               
               
                   
               
               
                 Contig48716_RC 
                 TATCAGGGTTTTGGGTGTCACTTAGGTTTTGTCCATCAGATTCTGTGAGACACCAGGCAT 
               
               
                   
               
               
                 Contig52675_RC 
                 CTGGAATACATTAAAGAAGCAAAAGAACCTCATACAAAAGTCATTGAGTAAATGACAGCC 
               
               
                   
               
               
                 Contig53315_RC 
                 AGAAAGAAGCCTTTTTCATTAAGGATACAACCTATTTGTAGCTCGCACTTTAAAAGATGC 
               
               
                   
               
               
                 Contig705_RC 
                 TATGTTTCTTCCAAGGAAACAGGAGAGACTGAATTAATAATTCTCTCTTTCCTCTTAAGC 
               
               
                   
               
               
                 NM_000542 
                 ACACACAGGATCTCTCCGAGCAGCAATTCCCCATTCCTCTCCCCTATTGCTGGCTCTGCA 
               
               
                   
               
               
                 NM_005328 
                 AAGGATTTTGGAAACTCAAGGAAAAGTTCTTTCAACCTATACAACCTAACTTATGGACTG 
               
               
                   
               
               
                 NM_005954 
                 CTGTGGTGAAGTGTTCCTGGTGTTCCCTTTCCCTGCTGACCTTGGAGGAATGACAATAAA 
               
               
                   
               
               
                 NM_014904 
                 GTTTTATCCATCAAAAAATGCACTCTCACAGTGGAGTTGAAGTCTAATACATGATACATG 
               
               
                   
               
               
                 NM_016021 
                 CTTATTGAGTACTCTGTTTCTACGTATGTAGAATGTATAGGGATAGAAGAGTTGAAAAGG 
               
               
                   
               
               
                 NM_016485 
                 AACATGATCAAGTCCTTCTATACTGCAAGTCTTTTGATAGATGTCATAACAGTATTGGAG 
               
               
                   
               
               
                 NM_016621 
                 AAACTAAAATAAGGAATAGAAAAGCTGTTTTTCAGGCTGACAGTCCAATTAAGGGTAGCC 
               
               
                   
               
               
                 NM_018451 
                 GACATGCTACCCTAATAATGAAATAGGTATCCTGGACAAAACAATAAAAAGGAAGATTGC 
               
               
                   
               
               
                 NM_020139 
                 TGCAAGAGAAGGTGCCAAAGTCATAGCCACAGACATTAATGAGTCCAAACTTCAGGAACT 
               
               
                   
               
               
                 AB002365 
                 CATTGTTTCTCAAAGCTCCTTGATTAAGAGAAAGAACAGAAATTTGCACAGAAGATAGTG 
               
               
                   
               
               
                 AB033080 
                 GCAAGCTCAGTCATACATGACAAAGTGTAATTAACACTGATGTTTGTGTTAAATTTGCAG 
               
               
                   
               
               
                 AB033094 
                 TAATGTAAAACTGGTTGAACAAAACCGATGCCTGATTGAATGAAAACAATTCTATGAGGC 
               
               
                   
               
               
                 AF097495 
                 ACTAGTATAAAACTGTAAATACTACTATAAGACATTGGCTTTTTCCAGACATGGATCCGG 
               
               
                   
               
               
                 AL161983 
                 CAAAACGTAGCTTAGCAAAGCTGTTACTAAACTGGAGAGATCCTTTAATACATAGAAATG 
               
               
                   
               
               
                 Contig20552_RC 
                 CAGGGTATTCTTCCAGGAGATTTGACCAGCAAGTGGAAAAATACCATAAACCCTGCTGAA 
               
               
                   
               
               
                 Contig25390_RC 
                 GGCTTATAGAGTTAGAAGTCAGTATTTCTTCTAATCTGAGGCTATGATCAGTCCCAGCTG 
               
               
                   
               
               
                 Contig25794_RC 
                 AGATACTGTATCTGGCTGTACTATACTAACAGTGATTTGCCTGCATGTGTTTGATAGAGA 
               
               
                   
               
               
                 Contig27901 
                 TTGAATCTCTTGCCAAAAGACATGGGTAAAATATCTGCCTCTCTCATAGAGATTTTAAGA 
               
               
                   
               
               
                 Contig28149_RC 
                 GTGAAGACAAGAATAAAGCCACTAGTAGAAGCATCGGATTAGACACAACCTCGTCACAAC 
               
               
                   
               
               
                 Contig45569_RC 
                 TGTCAGCAGACATGTTCATCCGATGATAGTACTGCAGTTTTCTATTAATAATTTGCAGAC 
               
               
                   
               
               
                 Contig565_RC 
                 CTAGATCGAAGCAAAACCGATTTTGCTTTCACCATTAAGGTTGCATTTTAATGCAGTTAT 
               
               
                   
               
               
                 Contig58556_RC 
                 GATGCCAAAATTAGTCTTCTCAAAGCTTTGAGTAGAGTAAGTGTGGGAATAAGCCAGTTT 
               
               
                   
               
               
                 NM_000504 
                 GTCATCAAGCACAACCGGTTCACAAAGGAGACCTATGACTTCGACATCGCCGTGCTCCGG 
               
               
                   
               
               
                 NM_001503 
                 GAAATATCAGACACACTCTGCTCATTCATGTCTCCTTCCACAGTTTATTTCCTCGCTTCC 
               
               
                   
               
               
                 NM_002130 
                 TAAAATAACAGCAAGTTTATGTGATCTTAAATCAAGGCTTGATTCAAGAACTGGTGTGGC 
               
               
                   
               
               
                 NM_002340 
                 GAATGCTGTTTGTGAGGTGTCTACAGGGTTTATAGTAGTCTTGTGGACACAGAAATGCAC 
               
               
                   
               
               
                 NM_003762 
                 CAGGTGGTGACTATCCTGTTGAGAAGCAAAAGATACTTTGCAAGTAAAAAATATGCCTCC 
               
               
                   
               
               
                 NM_003893 
                 CTTAAAGTTACGGGGCTTCGTTGAATGCTCCTTCCCCTAGGCAGCTGGTAATAGAGGGGT 
               
               
                   
               
               
                 NM_004408 
                 GCCCTGTTCTATAAATATCTATAAATACTCATATATATACACACCTACACATGGCCAACC 
               
               
                   
               
               
                 NM_004441 
                 GGTGATGTTCAACAGAAGTGAAGACAAAACAATATGCATCAGGAGAACAAGAGTAAACCC 
               
               
                   
               
               
                 NM_005177 
                 GGTTTCAAGTTCTTACCCTTCTCCTTCGAGCATATTCGGGAAGGGAAGTTTGAAGAGTGA 
               
               
                   
               
               
                 NM_005204 
                 AGCAATAAGCTGGACTAGTGTCCTAAAAATGGCTAACTGATGAATTAGAAGCCATCTGAC 
               
               
                   
               
               
                 NM_005474 
                 CTGATGTGGTCCTAGTCTCCGCCGGGTTTGATGCTGTTGAAGGACATCTGTCTCCTCTGG 
               
               
                   
               
               
                 NM_005687 
                 TGCAAAAAACTACAGACATCTCTGTGCTGTTTATTACAACAAGAATCCTGGGTTTGAGAT 
               
               
                   
               
               
                 NM_006764 
                 TCCAGTGAAAGTGTGAACCTGCGGATCGCTGCCGGTGAAACCATTGCACTGCTCTTTGAG 
               
               
                   
               
               
                 NM_007366 
                 ACGTTTTCTGAGAAAAAATAGCATGAAGCCTAAAGCCATTTCTTCCAAAAACAACATTGC 
               
               
                   
               
               
                 NM_012268 
                 CCACAACAAGTACATGGTGACTGAACGCGCCACCTACATCGGAACCTCCAACTGGTCTGG 
               
               
                   
               
               
                 NM_015990 
                 AGAAAGCCAGAAATTCCATCAATACATCTAGACAGATGTTTGCTTGTAGTTTTTGGTATC 
               
               
                   
               
               
                 AB002340 
                 TAGACTACCTCAGAATGTAGTCAAGAATTCACCCAGTGTTCTTTGGATGTCCCTTCCCTA 
               
               
                   
               
               
                 AB007867 
                 CATGAACTCTACAAGTACATCAACAAGTACTATGACCAGATCATCACTGCCCTGGAGGAG 
               
               
                   
               
               
                 AB033052 
                 CCATCTGAAATTGGATAGCCCACTGAAATTGAACATGCCTTCTCTTATAAATGTGTGGTG 
               
               
                   
               
               
                 AJ225028 
                 CCCATCTCCATTGCATTCATGTACTACCCTCAGTCTACACTCACAATCATCTTCTCCCAA 
               
               
                   
               
               
                 AK001836 
                 TGTCACCCAGTTCAGTACTTGGTACATAAAAGACAATAAATGTTTAACTGAGCCAAGATT 
               
               
                   
               
               
                 AL110145 
                 AGAAATAAGAATCAAGAGCAGCTATTGTTATCCTTAGAGTGTTTTCCGTCTAGGGCCGGC 
               
               
                   
               
               
                 AL110179 
                 AATTGCAATATTTGCAAACATGTGCCACAACAGTGTTCTTGGTGATGTTTCTAAAACAGT 
               
               
                   
               
               
                 AL110255 
                 GTAAATTCTTCAGGAATAAACTTCATGCTAGGTTAACATCAATGTATGGTTACAGCTTCC 
               
               
                   
               
               
                 AL161961 
                 GATTTACCTGAAAATCTTCACAACTGATCATTATCTCCTTCTCTTTGAGACCTGACTGAA 
               
               
                   
               
               
                 Contig14968_RC 
                 CAAAATGAGTTTCAGCCAGAGTTTCAGTTTGACTTAAGTCAATTAAGCAACATCTCAAGG 
               
               
                   
               
               
                 Contig27451_RC 
                 TTACATTATAAACTCTTTTGAAAAATGTATCTAAAATTTTTTAAGTTCTGTTTTGATTCC 
               
               
                   
               
               
                 Contig31351_RC 
                 CAGTTTCCTCTCATCAAATCTAAAATTCTCCAAAATACTCTCAGGCATAACATACTTAGC 
               
               
                   
               
               
                 Contig34363_RC 
                 TCCTTGATTGTGCTATGTTTCAGTGGAAGAAATTCTTTGAAGTAGATGTGAGTGAAAAAC 
               
               
                   
               
               
                 Contig34729_RC 
                 TGAGATCCTGCAATGAGCAATCCTTTAAGCACTTTCTTCCCCGTTATGCTCCAAAGTACG 
               
               
                   
               
               
                 Contig34962_RC 
                 AAATGACCACTAGAATAAAGAATTTTTCCAAACATCAGTGTCAAGCTCTTCCAATCAACC 
               
               
                   
               
               
                 Contig35186_RC 
                 TTTCATGAAACTGAATAAAAGAAATCCTTTCCGAGATAGAGGAGATTTGTAGGTGAATGC 
               
               
                   
               
               
                 Contig36275 
                 CCAAAAGTCAAGAATTCAACCAGCAATTAAATAATAATTCCTGTGGTAAAGCACTTTCCC 
               
               
                   
               
               
                 Contig36750_RC 
                 TCTGTACTTCCTAGACAACCTCCATTATTCCCTAAGGGAATCAGTGTTGTGTCTGTCTAC 
               
               
                   
               
               
                 Contig40877_RC 
                 AAACAAAGGCACGACCAGATAAGTGACTTCAAGGGAGTAAAGGTCGTTCTATCGGAGAAC 
               
               
                   
               
               
                 Contig40885_RC 
                 GGCTCAGAGAATCCTGCAAAATCCTTTTTTATTGTTTATTCTGCAGACAAAAATGTGACA 
               
               
                   
               
               
                 Contig43133_RC 
                 TGTGAAAAGAAAACAAACAACTTGTACCTTCTTTCTGATATCACCGTCATTCCTCTTTCT 
               
               
                   
               
               
                 Contig4324_RC 
                 CCCAGGGACTTTAAATTGAAGTCCTAGGGTTACTCAGTATAGGGAGGAAATGAGGACCAA 
               
               
                   
               
               
                 Contig43322_RC 
                 TTCTCCTTCAAAACACTCATCTCCTCTGTAATGATCAGATGAACTCATGTCTTTCTCAGA 
               
               
                   
               
               
                 Contig493_RC 
                 CATGCACATTGTCATGTGCAGCTTTGCATATACACACATGCATACATGAGCCTCCACACA 
               
               
                   
               
               
                 Contig49966_RC 
                 ATGGACAAATAGCTGTGTAAATAGCTTCTCATAAAACGCTTCTACTGATAGCTGTTTGAC 
               
               
                   
               
               
                 Contig56681_RC 
                 GTGCTCATTAATTCACGAGGCAGGATAAAATAGAAATTTCAAATTCTGATTGAATAGGCG 
               
               
                   
               
               
                 Contig6089_RC 
                 GGAAGCTGAAATGGTACCATAAATGCTGCTAATCTGAGAGCCATTTTAAACTGCACTGCT 
               
               
                   
               
               
                 Contig65995_RC 
                 CCCTCCATAATGAAAGAAGATAGGTTTATGCTTCTCTTTCCATTAATGTGCAGCCATTCT 
               
               
                   
               
               
                 Contig8054_RC 
                 TTAATTGAAATAATGCTTAAAGGCTGTTGCTTCTCTTTAAAATTGACCCAAGGCATGAGC 
               
               
                   
               
               
                 Contig8896_RC 
                 ACTTCGAAGGTATGTTTACAGGATGGATTAGCATGCACTTTACAGATATTTATGAAGTTG 
               
               
                   
               
               
                 D29810 
                 CTCCAAAAAATTTAGCCAAAGGTCGTGCCCCAAAATTTACGCAACCACTACAACCTCGCA 
               
               
                   
               
               
                 NM_000059 
                 AGTTTCAAATTTACCTCAGCGTTTGTGTATCGGGCAAAAATCGTTTTGCCCGATTCCGTA 
               
               
                   
               
               
                 NM_000245 
                 TGAACGTAAAATGTGTCGCTCCGTATCCTTCTCTGTTGTCATCAGAAGATAACGCTGATG 
               
               
                   
               
               
                 NM_000301 
                 GAGAATAAAGTGTGCAATCGCTATGAGTTTCTGAATGGAAGAGTCCAATCCACCGAACTC 
               
               
                   
               
               
                 NM_000527 
                 GCTTAAGAACATCAACAGCATCAACTTTGACAACCCCGTCTATCAGAAGACCACAGAGGA 
               
               
                   
               
               
                 NM_000757 
                 GCCAGACCATCTCTACCCTGTACTTGGACAACTTAACTTTTTTAACCAAAGTGCAGTTTA 
               
               
                   
               
               
                 NM_001289 
                 ACACAAAAGGAGGCAAATAAGAATTTTGAAAAATCTCTGCTCAAAGAATTCAAGCGTCTG 
               
               
                   
               
               
                 NM_001470 
                 GTACTTTCTTCCCTTAAATCATGGTATTCTTCTGACAGAGCCATATGTACCCTACCCTGC 
               
               
                   
               
               
                 NM_001798 
                 GCAAGATTTTAGTAAAGTTGTACCTCCCCTGGATGAAGATGGACGGAGCTTGTTATCGCA 
               
               
                   
               
               
                 NM_002167 
                 TAAAATGGATCCTGCACCACGGGAACCTCACAGCACCTCACTTCTTTTGGTTTTCTTTCT 
               
               
                   
               
               
                 NM_002231 
                 TTCGGATGGGCTGTTTAGATGTTATATAATCCACAAAAGGTTCATTGAGCTAAAAAAGTG 
               
               
                   
               
               
                 NM_002385 
                 GGCCAACAGTTAAATGAGAACATGAAAACAGAAAACGGTTAAAACTGTCCCTTTCTGTGT 
               
               
                   
               
               
                 NM_002673 
                 TGCATGAACTCTACAAGTACATCAACAAGTACTATGACCAGATCATCACTGCCCTGGAGG 
               
               
                   
               
               
                 NM_002912 
                 CAAAGTAGATCGTTATTTTGATCAAACTGTGCAAACAGTAGTACCACGTGTAGCATTTTG 
               
               
                   
               
               
                 NM_003174 
                 CAAAGTATTTTTCAATCAGAGTTTTCAGAACCTGACATTGTTAAAGATACTGCTTGTCCC 
               
               
                   
               
               
                 NM_003443 
                 GTGAAGCAAGTGCAGGAAGAAGACCCCAACACTCACATCCTCTACGCCTGTGACTCCTGT 
               
               
                   
               
               
                 NM_003632 
                 TAGCCAAAGCCATAAAAAACCTGCAACGTAGAGAAAATAATGCAGATACCCTGACTAGCC 
               
               
                   
               
               
                 NM_003809 
                 TGTTCACGTGTTTTCCATCCCACATAAATACAGTATTCCCACTCTTATCTTACAACTCCC 
               
               
                   
               
               
                 NM_004655 
                 GAGACTGCCATACATAATATATGACTTCCTAGGGATCTGAAATCCATAAACTAAGAGAAA 
               
               
                   
               
               
                 NM_004760 
                 CTTGGTCAGTGAAAAGATGCTACTATATTGCTTTTGTCCCAAAGTGAGTAAAATCCCCTA 
               
               
                   
               
               
                 NM_004937 
                 AGCGCATTAGCATAGTAACTCCTTTCAGATTTTTTGGAGGGACGTTTGGAAGTGGCTTAC 
               
               
                   
               
               
                 NM_005451 
                 GAGCGAGACTATGAGAAGATGTTTGGCACGAAATGCCATGGCTGTGACTTCAAGATCGAC 
               
               
                   
               
               
                 NM_006021 
                 AGCACGAATGATTCTATTAAAGAAAATCATTAGGAAGTGGTAGAAACTTTAAATCGCCCC 
               
               
                   
               
               
                 NM_006328 
                 TGTTAAGTGTTCGGCAGTAACCTACTTTGTTCCTTCGCCTCAGCAGCAAATCTTGCTACT 
               
               
                   
               
               
                 NM_006271 
                 TAGGCTAAATTTCTCCAGCCTCACAATGGTCTTCACTTGGTCTGACTTGTACCAATTCTA 
               
               
                   
               
               
                 NM_006459 
                 GGAACAATCATTATACGGACTCTTCAGATTTACAGAGAACTTACACTTCATCTGTTCCAC 
               
               
                   
               
               
                 NM_006541 
                 TTTGTCTGATATTTAGAGACATTCAGATTCAGAAGCCATGAGTTCAGTTAGCTCATGGCC 
               
               
                   
               
               
                 NM_007086 
                 CCTTGAAAAATCATTAAAGCCAAGGTATTAAAACCTTTGTGCATTAATACCTTCTAGGGG 
               
               
                   
               
               
                 NM_012301 
                 CTTAGGTTCCGTCTCACGGCGTTTTAATTTATTTTCACTGTCACACGCATAGATCCACGA 
               
               
                   
               
               
                 NM_013402 
                 TGACACAGATGAACCATATTCCCATGCACATTGATCATGACCGGAACATGGACTGGGTTT 
               
               
                   
               
               
                 NM_014813 
                 TTGCCCTAGTCTTCAGAATGGTCCTGAGAAAACATCACTACTTCGATGTTCTACTTTGCT 
               
               
                   
               
               
                 NM_016336 
                 CAGAATTGAAAGATCCAACAGATCATTACCATGCGCAGCTTTTAGAGGATAACCTTTTTG 
               
               
                   
               
               
                 NM_018155 
                 TCCAGTAAAATAACAGCAATGACAATGAGATCGTCAGTATTATTTTCACATTTCCCTGAG 
               
               
                   
               
               
                 NM_018283 
                 TCTAAACCAAGAGAAGTGAGACAAACCATCTAATATCTGTATCATGCTATTAATAGGCTG 
               
               
                   
               
               
                 NM_018677 
                 GAACGCTTTGAGACAACCTACTTTAAGAAGTTTCCTGGATACTATGTTACAGGAGATGGC 
               
               
                   
               
               
                 NM_020524 
                 GCTGTGCAACAGACAGGTGATGATGATGAAGTAGATGACTTTGAGGACTTCATCTTCAGC 
               
               
                   
               
               
                 U00952 
                 TGTCGTCGTCGAAGTAGATGACTTTGAGGACTTCATCTTCAGCCACTTCTTTGGAGACAA 
               
               
                   
               
               
                 Gene_symbol indicates the name of the gene, if known. Two identical names occur when more sequences of one and the same gene are present on the array. Centroid represents the mean expression (log 10 ratio) of a gene in a patient with local recurrence. Order_sig is the rank in significant expression on the total array (which contained 24.496 genes, indicated number is in the range from 1 (high) to 24.496 (low)). The last two columns indicate the UniGene duster notations, in 
                 which 172 indicates the updated version. 
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2 
               
             
            
               
                   
               
               
                 Multivariate analysis (Cox-Regression) for 
               
               
                 some clinical parameters and LR profile. 
               
            
           
           
               
               
               
            
               
                   
                   
                 95.0% CI for 
               
               
                   
                 Hazard 
                 hazard Ratio 
               
            
           
           
               
               
               
               
               
            
               
                   
                 Significance 
                 Ratio 
                 Lower 
                 Upper 
               
               
                   
                   
               
            
           
           
               
               
               
               
               
            
               
                 T2   T1 
                 0.873 
                 2.044 
                 .274 
                 15.276 
               
               
                 Grade III   I&amp;II 
                 0.290 
                 2.300 
                 .380 
                 13.942 
               
               
                 Age &lt;40   &gt;40 
                 0.073 
                 2.297 
                 .219 
                 24.048 
               
               
                 CHT No   Yes 
                 0.115 
                 .330 
                 .063 
                 1.731 
               
               
                 HORMONAL No   Yes 
                 0.308 
                 .259 
                 .039 
                 1.703 
               
               
                 Boost Yes   No 
                 0.438 
                 .763 
                 .051 
                 11.338 
               
               
                 LR Classifier +   − 
                 0.000 
                 23.736 
                 2.530 
                 222.639 
               
               
                   
               
               
                 1) Tumor size: T1 vs T2 (&lt;=2 cm or &gt;2 cm) 
               
               
                 2) Pathological grade III vs I-II 
               
               
                 3) Patient&#39;s age at diagnosis 
               
               
                 4) Yes or no adjuvant chemotherpy 
               
               
                 5) Yes or no adjuvant hormonal therapy 
               
               
                 6) Yes or no boost dose 
               
               
                 7) Activated or quiescent Wound Signature