Patent Publication Number: US-2005129788-A1

Title: Herbal product to be administered to diabetic individuals and the production method thereof

Description:
The object of the present invention is a herbal product developed and appropriate for the administration to diabetic people and more specifically to people who suffer from diabetes type II, not dependent from insulin.  
      The formulation of this herbal product is made up of the mixture of two plants, one of them belonging to the  Myrtaceae  and the other to the family of the  leguminosae - caesalpinoideae.  Specifically, the first of them is a  Syzygium  and the second a  Bauhinia.    
      This product has a hypoglycaemic activity. Its mimetic activity with human insulin allows to reduce the glycose levels in patients with diabetes type II; in an unedited way in pharmacology of herbal formulations.  
      On the other hand and as they are products obtained from the mixture of two natural plants, the collateral effects on the patients are low or almost nonexistent, which supposes a great advantage as compared to the traditional chemical formulae.  
      According to the present invention a herbal product is tried to obtain, for its administration to diabetic patients, and more specifically to those suffering from type II, not insulin dependent diabetes. 
    
    
     Formulation  
      The qualitative formulation of this product is the one made up of the mixture of two plants, one of them belonging to the  Myrtaceae  and the other to the family of the  leguminosae - caesalpinoideae.    
      Specifically, the plant belonging to the  Myrtaceae  is a  Syzygium  and more specifically in a preferable but not limitative way the species  Syzygium cumini  or  Syzygium jambolanum  as selected varieties.  
      The plant of the  leguminosae - caesalpinoideae  family is a  Bauhinia  and specifically in a preferable but not limitative way of the species  Bauhinia  spp.  
      The quantitative formulae is determined by a percentage by weight included between 50% and 95% of the  Syzygium  and a percentage by weight included between 5% and 50% of  Bauhinia.    
      Within these percentages by weight satisfactory results have been reached with a percentage by weight of 85% of  Syzygium  and a percentage by weight of 15% of  Bauhinia.    
      Particularly samples have been prepared of the product in which the weight of the plants was 450 mg. In this case, the amount of  Syzygium  is 382.5 mg and the amount of  Bauhinia  is 67.5 mg.  
      The presentation of the product can be any of the ones allowed by the pharmacopean techniques but preferably it shall be presented in capsules.  
     Production Process  
      The process is started with the gathering or harvesting of the plants, after which the  Syzygium  seeds are cleaned as well as the  Bauhinia  leaves.  
      Both the seeds of  Syzygium  and the leaves of  Bauhinia  are pulverized to 60 mesh and afterwards dried till reaching 9% humidity.  
      After a quality control process, the grinding phase is started, in which the seeds and the leaves are ground, after which they are sterilized.  
      In the following phase both ground plants are mixed till reaching a perfect homogenization, after which they are capsulized after passing the corresponding quality controls. Finally the finished product is packed.  
     Dosage  
      As a possible administration dose, satisfactory results have been reached with the following dosage: 
          A first attacking dose, according to which 4 capsules of 450 mg should be taken, each of them daily for a period of one week.     A maintenance dose of two capsules of 450 mg, each of them daily during the remaining 51 weeks, to complete, between the attacking dose and the maintenance one a period of one year.        

      It is convenient that the capsule ingestion is carried out twice a day; so that during the attacking dose two capsules shall be taken before breakfast in the morning and two other ones before dinner.  
      A capsule shall be taken before breakfast and another one before dinner for the maintenance dose.