Patent Publication Number: US-2007122795-A1

Title: Information processing apparatus, information processing method, information processing system, program, and recording medium

Description:
CROSS REFERENCES TO RELATED APPLICATIONS  
      The present invention contains subject matter related to Japanese Patent Application JP 2005-266728, filed in the Japanese Patent Office on Sep. 14, 2005, the entire contents of which being incorporated herein by reference.  
     BACKGROUND OF THE INVENTION  
      1. Field of the Invention  
      The present invention relates to an information processing apparatus, method, system, and program, and a recording medium. More particularly, the present invention relates to an information processing apparatus, method, system, and program, and a recording medium, which are intended to digitize the relation between intermolecular interactions and cellular functions.  
      2. Description of Related Art  
      There are many diseases involving gene defects. They include genetic metabolic diseases induced by a single gene defect as well as cancerous diseases induced by a plurality of gene defects which have accumulated with time. Analyzing whether a specific gene (and its product) is normal or abnormal is important in understanding the origin of a disease and establishing the plan for medical treatment.  
      This has been generally achieved by the technique which involves investigating the copy number of a specific gene of interest, confirming the degree of transcription of the gene, performing DNA sequencing on the amplified product of RT-PCR of the gene, detecting mutation by the thus obtained base sequence, and confirming immunohistochemically the localization of the gene at the protein level or the change in expression of the gene. This technique has helped accumulate a large amount of knowledge, some of which is used as an essential method for clinical test.  
      The copy number of the gene may be investigated by using the Southern blotting technique, which involves treating a sample with a restriction enzyme, transferring the treated sample to a nitrocellulose membrane by electrophoresis, and hybridizing the transferred sample to find a specific base sequence. The degree of transcription of the gene may be investigated by using the Northern blotting technique, which involves separating RNA by gel electrophoresis, transferring the separated RNA to a nylon membrane, hybridizing the transferred RNA with a labeled probe, and detecting the desired molecules.  
      These classic techniques of the first generation are followed by the new techniques of the second generation, which are designed to examine a very large number of genes and proteins comprehensively at one time. They have been developed for the human genome project, which needs to examine a large number of genes comprehensively at one time. Nowadays, comprehensive analyses are carried out not only for genes (genome) but also for RNAs (transcriptome), proteins (proteome), and metabolites (metabolome). Many methods have been devised to utilize the resulting data for disease diagnosis and medical treatment.  
      There have been proposed many methods for studying how a change in mRNA affects a disease by computer analysis of comprehensive data originating from transcriptome which is a collection of mRNAs or all of transcription products in a cell. Among them is a method for knowing the property of cancer and devising the medical treatment of cancer by analyzing the expression profile of mRNA and other molecular data. For example, refer to following Patent Documents 1 to 9.  
      Patent Document 1:  
      Japanese Patent Laid-open No. 2005-34151,  
      Patent Document 2:  
      Japanese Patent Laid-open No. 2004-329211,  
      Patent Document 3:  
      JP-A-2005-514051,  
      Patent Document 4:  
      JP-A-2005-512557,  
      Patent Document 5:  
      JP-A-2005-514359,  
      Patent Document 6:  
      JP-A-2005-518522,  
      Patent Document 7:  
      JP-A-2005-500832,  
      Patent Document 8:  
      JP-A-2005-503779,  
      Patent Document 9:  
      JP-A-2005-508199.  
      There has been disclosed a technique for a drawing a graph that shows nodes representing proteins and edges representing their interactions and then visualizing it three-dimensionally by using a parameter called spring force. (For example, see Patent Document 10: Japanese Patent Laid-open No. 2004-118819.)  
      There has also been disclosed a technique for visualizing by means of nodes and links a table that shows interactions and their intensity between objects such as proteins. (For example, see Patent Document 11: Japanese Patent Laid-open No. 2004-30034.)  
     SUMMARY OF THE INVENTION  
      Unfortunately, the techniques disclosed in Patent Documents 1 to 9 above are designed to analyze comprehensive data, abstract their feature, and find their relation with specific diseases. They do not give any information about how a set of data of gene increase or decrease relates with specific diseases. Even though they provide the relation between the presence of gene expression cluster and the clinical data, they do not indicate the significance of the relation. Therefore, they do not permit one to ascertain the difference between meaningful data fluctuation and meaningless data fluctuation due to sample preparation for comprehensive data.  
      In addition, the techniques disclosed in Patent Documents 10 and 11 make intermolecular interactions visual but have no way of digitizing and predicting intermolecular interactions.  
      The present invention was completed in view of the foregoing. It is intended to digitize the relation between intermolecular interactions and cellular functions.  
      The first embodiment of the present invention is directed to an information processing apparatus which includes acquisition means, arithmetic means, and output control means. The acquisition means acquires the amount of the molecules for detection which have been produced by control cells and sample cells. The arithmetic means receives from the acquisition means the information about the amount of the molecules for detection which have been produced by the control cells and the sample cells, thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection. The output control means controls the output of the score which has been calculated by the arithmetic means for the cellular function.  
      In the information processing apparatus, the acquisition means acquires the amount of the molecules for detection which have been produced by the control cells and the sample cells, according to the amount of the nucleic acid which has been expressed in response to the molecules for detection which have been collected from the control cells and the sample cells.  
      In the information processing apparatus, the combination of the two molecules for detection is classified into the following five categories according to the interrelation between the two molecules; the first category applicable to two molecules which suppress each other, the second category applicable to two molecules the first one of which promotes the second one and the second one of which suppresses the first one, the third category applicable to two molecules which promote each other, the fourth category applicable to two molecules only one of which promotes the other, and the fifth category applicable to two molecules only one of which suppresses the other.  
      In the information processing apparatus, the arithmetic means calculates the score for the cellular functions by accumulating for each cellular function those values which are obtained by giving the score based on the amount of the molecules for detection which have been produced in the control cells and the sample cells to the cellular functions relating to the mutual promotion or suppression between the two molecules for detection which belong to the first to third categories out of the five categories and then multiplying a prescribed factor.  
      In the information processing apparatus, the prescribed factor is established such that it takes on the largest value for the cellular function relating to the first category of the first to third categories out of the five categories and it also takes on the smallest value for the cellular function relating to the third category of the first to third categories out of the five categories.  
      In the information processing apparatus, the prescribed factor is larger than 1 when the two molecules for detection have a molecular bond.  
      The information processing apparatus further includes storage means that stores in a table form the information about the combination of the two molecules for detection which are classified into any of the five categories and the cellular function relating to the mutual promotion or suppression of the two molecules for detection.  
      The information processing apparatus further includes estimating means that estimates the score for the cellular function when there is any change in the amount of the molecules for detection which have been produced in the control cells and the sample cells after it has been acquired by the acquisition means.  
      The information processing apparatus further includes network building means that builds a network for the information about the interrelation of the molecules for detection, so that the estimating means calculates the effect of change in the amount of the molecules for detection which have been produced on other molecules based on the network which has been built by the network building means, thereby estimating the score for the cellular function.  
      The information processing apparatus further includes analyzing means that analyzes the change with time of the cellular function based on the score for the cellular function, with its output being controlled by the output control means.  
      The second embodiment of the present invention is directed to an information processing method or an information processing program which includes the steps of acquiring the amount of the molecules for detection which have been produced in the control cells and the sample cells, receiving the information about the amount of the molecules for detection which have been produced in the control cells and the sample cells, thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection.  
      The third embodiment of the present invention is directed to an information processing system which includes an analyzing unit that analyzes the amount of the molecules for detection which have been produced in the control cells and the sample cells and an information processing apparatus that analyzes the information about the cellular function relating to the mutual promotion or suppression of the two molecules for detection. The information processing apparatus has acquisition means, arithmetic means, and output control means. The acquisition means acquires the amount of the molecules for detection which have been produced by control cells and sample cells. The arithmetic means receives from the acquisition means the information about the amount of the molecules for detection which have been produced by the control cells and the sample cells, thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection. The output control means controls the output of the score which has been calculated by the arithmetic means for the cellular function.  
      The information processing system includes the steps of acquiring the amount of the molecules for detection which have been produced in the control cells and the sample cells, receiving the information about the amount of the molecules for detection which have been produced in the control cells and the sample cells, thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection.  
      The network denotes any setup which consists of at least two apparatus connected to each other so that information can be transmitted from one apparatus to the other. The apparatus capable of communication through the network may be those which are independent from one another or those which are constituent units of one apparatus.  
      The term “communication” means wireless and wire communications or a mixture thereof. In the latter case, wireless communication may be carried out in some sections and wire communication may be carried in other sections. Another mode of communication may be such that wire communication is carried out from the first apparatus to the second apparatus and wireless communication is carried out from the second apparatus to the first apparatus.  
      The above-mentioned information processing apparatus according to the present invention is able to analyze the cellular function relating to the molecules for detection. It is also able to classify the overall relation between molecules, thereby digitizing the relation between the intermolecular interaction and the cellular function.  
    
    
     BRIEF DESCRIPTION OF THE DRAWINGS  
       FIG. 1  is a block diagram illustrating a protein analyzing system to which the present invention is applied;  
       FIG. 2  is a diagram illustrating the classification of the interrelation between two molecules;  
       FIGS. 3A  to  3 F are diagrams illustrating the relation between the NN-type molecules and the cellular function;  
       FIGS. 4A  to  4 H are diagrams illustrating the relation between the PN-type molecules and the cellular function;  
       FIGS. 5A  to  5 H are diagrams illustrating the relation between the PN-type molecules and the cellular function;  
       FIGS. 6A  to  6 H are diagrams illustrating the relation between the PN-type molecules and the cellular function;  
       FIGS. 7A  to  7 G are diagrams illustrating the relation between the PN-type molecules and the cellular function;  
       FIGS. 8A  to  8 G are diagrams illustrating the relation between the PN-type molecules and the cellular function;  
       FIGS. 9A  to  9 F are diagrams illustrating the relation between the PN-type molecules and the cellular function;  
       FIGS. 10A  to  10 G are diagrams illustrating the relation between the PP-type molecules and the cellular function;  
       FIGS. 11A  to  11 G are diagrams illustrating the relation between the PP-type molecules and the cellular function;  
       FIGS. 12A  to  12 G are diagrams illustrating the relation between the PP-type molecules and the cellular function;  
       FIGS. 13A  to  13 G are diagrams illustrating the relation between the PP-type molecules and the cellular function;  
       FIGS. 14A  to  14 F are diagrams illustrating the relation between the PP-type molecules and the cellular function;  
       FIG. 15  is a diagram illustrating the relation between the NN-type molecules and the cellular function;  
       FIG. 16  is a diagram illustrating the relation between the PN-type molecules and the cellular function;  
       FIG. 17  is a diagram illustrating the relation between the PP-type molecules and the cellular function;  
       FIG. 18  is a diagram illustrating how to calculate the cell score;  
       FIG. 19  is a diagram illustrating how to calculate the cell score;  
       FIG. 20  is a diagram illustrating the simulation which is carried out when the prescribed cell score is changed;  
       FIG. 21  is a diagram illustrating one example of the molecule network;  
       FIG. 22  is a flow chart illustrating the process for analysis;  
       FIG. 23  is a flow chart illustrating the process for accumulating points;  
       FIG. 24  is a flow chart illustrating the process  1  for inferring the target molecule;  
       FIG. 25  is a flow chart illustrating the process  2  for inferring the target molecule; and  
       FIG. 26  is a diagram illustrating the structure of a personal computer. 
    
    
     DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS  
      The following is a detailed description of the embodiments according to the present invention. This description is intended to ensure that the embodiments according to the present invention conform to the specification and drawings therein. The embodiments may include those which have the constituents of the present invention which are not shown in the specification or the drawings therein. This does not necessarily mean that such embodiments do not correspond to the constituents of the present invention. Conversely, even though some embodiments may be written as conforming to the constituents of the present invention, it does not necessarily mean that such embodiments do not conform to other constituents than the constituents.  
      The information processing apparatus according to the present invention has acquisition means (such as the arithmetic unit  21  shown in  FIG. 1  which calculates the ratio of the amount of protein expressed) that acquires the amount of the molecules for detection which have been produced by control cells (such as normal cells) and sample cells, arithmetic means (such as the point accumulating unit  22  shown in  FIG. 1 ) that receives from the acquisition means the information about the amount of the molecules for detection which have been produced by the control cells and the sample cells (such as the ratio of protein expressed which is inferred from the amount of mRNA expressed or measured by the protein kit  7 ), thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection, and output control means (such as the result output unit  28  shown in  FIG. 1 ) that controls the output of the score which has been calculated by the arithmetic means for the cellular function.  
      The combination of the two molecules for detection is classified into the following five categories according to the interrelation between the two molecules; the first category (such as NN-type) applicable to two molecules which suppress each other, the second category (such as PN-type) applicable to two molecules the first one of which promotes the second one and the second one of which suppresses the first one, the third category (such as PP-type) applicable to two molecules which promote each other, the fourth category (such as N-type) applicable to two molecules only one of which promotes the other, and the fifth category (such as P-type) applicable to two molecules only one of which suppresses the other.  
      The information processing apparatus may additionally have storage means (such as the protein information database  3 ) that stores in a table form (shown in  FIGS. 3 and 4 ) the information about the combination of the two molecules for detection which are classified into any of the five categories (as shown in Tables 1 to 7) and the cellular function relating to the mutual promotion or suppression of the two molecules for detection.  
      The information processing apparatus may additionally have inferring means (such as the target molecule inferring unit  27  shown in  FIG. 1 ) that infers the score for the cellular function when there is any change in the amount of the molecules for detection which have been produced in the control cells and the sample cells after it has been acquired by the acquisition means.  
      The information processing apparatus may additionally have network building means (such as the network building unit  26  shown in  FIG. 1 ) that builds a network for the information about the interrelation of the molecules for detection, so that the inferring means calculates the effect of change in the amount of the molecules for detection which have been produced on other molecules based on the network which has been built by the network building means, thereby inferring the score for the cellular function.  
      The information processing apparatus may additionally have analyzing means (such as the result analyzing unit  6  shown in  FIG. 1 ) that analyzes the change with time of the cellular function based on the score for the cellular function, with its output being controlled by the output control means.  
      The information processing method or program according to the present invention includes the step of acquiring the amount of the molecules for detection which have been produced in the control cells (such as normal cells) and the sample cells (the step being represented by Step S 3  in  FIG. 22 ), and the step of receiving the information about the amount of the molecules for detection which have been produced in the control cells and the sample cells (the information being the ratio of expression of protein), thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection (the step being represented by Step S 5  in  FIG. 22  or the process explained with reference to  FIG. 23 ).  
      The information processing system according to the present invention includes an analyzing unit (such as the mRNA expression analyzing unit  2  shown in  FIG. 1 ) that analyzes the amount of the molecules for detection which have been produced in the control cells (such as normal cells) and the sample cells and an information processing apparatus (such as the protein information analyzing unit  4  shown in  FIG. 1 ) that analyzes the information about the cellular function relating to the mutual promotion or suppression of the two molecules for detection. The information processing apparatus has acquisition means, arithmetic means, and output control means. The acquisition means (such as the arithmetic unit  21  shown in  FIG. 1  calculates the ratio of the amount of protein expressed) that acquires the amount of the molecules for detection which have been produced by control cells and sample cells. The arithmetic means (such as the point accumulating unit  22  shown in  FIG. 1 ) receives from the acquisition means the information about the amount of the molecules for detection which have been produced by said control cells and said sample cells (said information being the ratio of protein expressed), thereby calculating the score that indicates whether one of the two molecules for detection promotes or suppresses the other and also indicates whether the cellular function is promoted or suppressed depending on the combination of cellular functions for the mutual promotion or suppression between the two molecules for detection. The output control means (such as the result output unit  28  shown in  FIG. 1 ) controls the output of the score which has been calculated by the arithmetic means for the cellular function.  
      The embodiment of the present invention will be described with reference the accompanying drawings.  
       FIG. 1  is a block diagram illustrating the structure of the protein information analyzing system to which the present invention is applied.  
      The protein information analyzing system includes the chip forming unit  1 , the mRNA expression analyzing unit  2 , the protein information database  3 , the protein information analyzing unit  4 , the result display unit  5 , and the result analyzing unit  6 . It may also have the protein kit  7 .  
      The chip forming unit  1  yields a DNA chip (or DNA microarray) which has as the probe a nucleic acid with the base sequence structure complementary to the molecule (protein) for detection.  
      The mRNA expression analyzing unit  2  is so designed as to drop the control target and the detection target onto the DNA chip which has been prepared by the chip forming unit  1 , thereby determining the amount of the molecule (protein) for detection in each case. The control target is produced by the mRNA collected from the normal cell (control cell), and the detection target is obtained by reverse transcription (for duplication) of the complementary DNA (cDNA) from the mRNA collected from the sample cell. In other words, the mRNA expression analyzing unit  2  performs hybridization, which utilizes the reaction to form the complementary strands (double strands) between nucleic acids each having the complementary base sequence, and then determines, by fluorescence intensity analysis with an intercalator, the amount of the molecule (protein) for detection which has been expressed in the normal cell and the amount of the molecule (protein) for detection which has been expressed in the sample cell, and supplies the thus obtained result to the protein information analyzing unit  4 .  
      The foregoing units may be replaced by the protein kit  7 , which is designed to detect comprehensively the molecules (proteins) for detection by using protein chips.  
      The protein information database  3  stores information about the protein to be used for processing by the protein information analyzing unit  4 . The protein information database  3  may be connected, by wire or wireless (e.g., through the Internet or LAN or WAN network), directly to the protein information analyzing unit  4 . It may also be installed inside the protein information analyzing unit  4 .  
      The combination of two different protein molecules can be classified into five categories according to their intermolecular interactions. The protein information database  3  stores information about the classification of the combination of two protein molecules belonging to each category. (The classification is referred to as molecule set.)  
      As shown in  FIG. 2 , the combinations of two molecules (or the intermolecular interrelations between two molecules) are classified into five categories (NN-type, PN-type, PP-type, P-type, and N-type) according to whether one molecule promotes or suppresses the other.  
      The NN-type denotes a combination in which two molecules suppress each other. The two molecules in the NN-type combination function as the molecular switch, with one representing “ON” if it dominates over the other quantitatively and functionally, and the other representing “OFF”.  
      The PN-type denotes a combination in which the first molecule promotes the second molecule and the second molecule suppresses the first molecule. In other words, two molecules perform contradictory functions (promotion and suppression) on each other. In this case, the information about the molecule for promotion converges on a certain value with oscillation as the result of negative feedback.  
      The PP-type denotes a combination in which two molecules promote each other. While two molecules are promoting each other, the information about the two molecules is amplified as the result of positive feedback.  
      The P-type denotes a combination in which one molecule promotes the other. The N-type denotes a combination in which one molecule suppresses the other.  
      Tables 1 to 9 show the NN-type combination (molecule set) of molecules.  
                               TABLE 1                                   Protein A       Protein B                          A2N   NN   LRPAP1           A2N   NN   PLG           ABO   NN   EGF           ACE   NN   ANGPTA           ACE   NN   BDK           ACE   NN   CIIorf3           ACE   NN   cyclic GNP           ACE   NN   HHL           ACE   NN     E           ACE   NN   TACI           ACHE   NN   acetylthiocholine           ACHE   NN   BCHE           ADCY2   NN   AGTR1           ADCY2   NN   CHR1           ADCY2   NN   DRD2           ADCY2   NN   EDN1           ADCY2   NN   GR 2           ADCY2   NN   NPPA           ADCY2   NN   P2Y receptor           ADCY2   NN   phospholipase C           ADCY2   NN   RAF1           ADCY2   NN   SSTR5           ADCY2   NN   TNFO1           ADRBK1   NN   GRK5           ADRBK1   NN   RPS6K           AFP   NN   TP53           AGT   NN   ADCY2           AGT   NN   ANG           AGT   NN   KCKD3           AGT   NN   prosteglandin-                   endoperoxide synthase           AGTR1   NN   AGTR2           AGTR1   NN   cAYP           AHR   NN   estradiol           AKT1   NN   BAK           AKT1   NN   FOS           AKT1   NN   GRB2           AKT1   NN   PCK2           AKT1   NN   PIK2B           AKT1   NN   PTPK6           AKT1   NN   RAP1GA1           AKT1   NN   TKFAIP8           ALB   NN   ELA2           ALB   NN   FUT4           ALB   NN   hyaluronoglucuronidase           ALB   NN   Na+, K+ ATPase           ananain   NN   BDK           ANGPT2   NN   ACK           APAF1   NN   ABL1           APC   NN   CCND1           APC   NN   SNADA           APOA1   NN   cholesteryl ester           APOE   NN   LRPAP1           AOP2   NN   AOP3           ARF6   NN   TFAP2A           AVP   NN   CRHP1           AVP   NN   REN           BAD   NN   BAK1           BAX   NN   BCL2           Bbaa1l   NN   SELE           BCAR1   NN   GNB2L1           BCAR1   NN   NEDD9           BCL2   NN   anyloid protein           BCL2   NN   BAK1           BCL2   NN   HRK           BCL2   NN   NR3C1           BCL2   NN   PDCD3           BCL2   NN   TNFAIP8           BCL2   NN   TNFRSF6                      
 
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 2 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 BCL2L1 
                 NN 
                 BAK1 
               
               
                   
                 BCL2L1 
                 NN 
                 BID 
               
               
                   
                 BCL2L1 
                 NN 
                 sphingosine 
               
               
                   
                 BCL2L1 
                 NN 
                 TNFRASF6 
               
               
                   
                 BCL6 
                 NN 
                 PRDH1 
               
               
                   
                 BDK 
                 NN 
                 ANP 
               
               
                   
                 BDK 
                 NN 
                 DNOLI 
               
               
                   
                 BDK 
                 NN 
                 NNE 
               
               
                   
                 BDK 
                 NN 
                 TGFA 
               
               
                   
                 beta-o-glucose 
                 NN 
                 CAT 
               
               
                   
                 oxidase 
               
               
                   
                 BF 
                 NN 
                 SERPING1 
               
               
                   
                 BH2HB2 
                 NN 
                 BHLHB3 
               
               
                   
                 BIO 
                 NN 
                 TRFAIP8 
               
               
                   
                 BIRC3 
                 NN 
                 CASP3 
               
               
                   
                 BIRC3 
                 NN 
                 TNFSF10 
               
               
                   
                 BHP4 
                 NN 
                 BRP4 receptor 
               
               
                   
                 BHP4 
                 NN 
                 PITX2 
               
               
                   
                 BHP4 
                 NN 
                 tumor necrosis factor 
               
               
                   
                 BU618 
                 NN 
                 CDC2 
               
               
                   
                 CALCA 
                 NN 
                 calmodulin 
               
               
                   
                 calmodulin 
                 NN 
                 ADREX1 
               
               
                   
                 calmodulin 
                 NN 
                 ELK1 
               
               
                   
                 calmodulin 
                 NN 
                 GAP43 
               
               
                   
                 calmodulin 
                 NN 
                 SHAD2 
               
               
                   
                 calpain 
                 NN 
                 APOE 
               
               
                   
                 calpain 
                 NN 
                 NEXBIA 
               
               
                   
                 CALR 
                 NN 
                 calcitriol 
               
               
                   
                 casein kinase 
                 NN 
                 GJA1 
               
               
                   
                 CASP3 
                 NN 
                 BIRC2 
               
               
                   
                 CASP3 
                 NN 
                 CD28 
               
               
                   
                 CASP3 
                 NN 
                 CDC42 
               
               
                   
                 CASP3 
                 NN 
                 COLI1A1 
               
               
                   
                 CASP3 
                 NN 
                 dihydrosphingosine 
               
               
                   
                   
                   
                 kinase 
               
               
                   
                 CASP3 
                 NN 
                 HSPB2 
               
               
                   
                 CASP3 
                 NN 
                 IGF2 
               
               
                   
                 CASP3 
                 NN 
                 map kinase 
               
               
                   
                 CASP3 
                 NN 
                 NCL1 
               
               
                   
                 CAT 
                 NN 
                 CASP3 
               
               
                   
                 CAT 
                 NN 
                 cytokine activity 
               
               
                   
                 CAT 
                 NN 
                 HIFIA 
               
               
                   
                 CAT 
                 NN 
                 HNOK1 
               
               
                   
                 CAT 
                 NN 
                 LP0 
               
               
                   
                 CAT 
                 NN 
                 HAPKAP1 
               
               
                   
                 catecholamine 
                 NN 
                 mitochondrial 
               
               
                   
                   
                   
                 processing peptidase 
               
               
                   
                 CAV1 
                 NN 
                 ADCY2 
               
               
                   
                 CAV1 
                 NN 
                 FGF2 
               
               
                   
                 CAV1 
                 NN 
                 HDL 
               
               
                   
                 CBL 
                 NN 
                 TCN2 
               
               
                   
                 CCL2 
                 NN 
                 GJA1 
               
               
                   
                 CCL2 
                 NN 
                 RGS1 
               
               
                   
                 CCL2 
                 NN 
                 RGS3 
               
               
                   
                 CCL2 
                 NN 
                 RGS4 
               
               
                   
                 CCL42 
                 NN 
                 CYP2E1 
               
               
                   
                 CCNNA2 
                 NN 
                 CDKN2A 
               
               
                   
                 CCNA2 
                 NN 
                 RBL2 
               
               
                   
                 CCND1 
                 NN 
                 CDKN2A 
               
               
                   
                 CCND1 
                 NN 
                 GSK3B 
               
               
                   
                 CCND1 
                 NN 
                 PPARA 
               
               
                   
                 CCND1 
                 NN 
                 PPARG 
               
               
                   
                 CCNE1 
                 NN 
                 STAT3 
               
               
                   
                 CCNE1 
                 NN 
                 RBI 
               
               
                   
                 CCNE1 
                 NN 
                 SNARCA4 
               
               
                   
                 CCR5 
                 NN 
                 coreceptor 
               
               
                   
                 CD4 
                 NN 
                 PRF1 
               
               
                   
                 CDB6 
                 NN 
                 CD28 
               
               
                   
                 CDA 
                 NN 
                 SLC9A3 
               
               
                   
                 CCDC2 
                 NN 
                 CDKNIA 
               
               
                   
                 CDC2 
                 NN 
                 NYT1 
               
               
                   
                 CDC2 
                 NN 
                 PAPOLA 
               
               
                   
                 CDC2 
                 NN 
                 RB1 
               
               
                   
                 CDC2 
                 NN 
                 NEE1 
               
               
                   
                 CDC42 
                 NN 
                 GD1 
               
               
                   
                 CDC42 
                 NN 
                 NLC1 
               
               
                   
                 CDH1 
                 NN 
                 CDC2 
               
               
                   
                 CDH1 
                 NN 
                 CDC20 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 3 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 CDK2 
                 NN 
                 CDK2AP1 
               
               
                   
                 CDK2 
                 NN 
                 CIB1 
               
               
                   
                 CDK2 
                 NN 
                 PSND9 
               
               
                   
                 CDK2 
                 NN 
                 SNARCA4 
               
               
                   
                 CDK4 
                 NN 
                 HYOD1 
               
               
                   
                 CDK5 
                 NN 
                 CDC2 
               
               
                   
                 CDK5 
                 NN 
                 CDKN2A 
               
               
                   
                 CDK6 
                 NN 
                 CDKN1A 
               
               
                   
                 CDKN1A 
                 NN 
                 E2F4 
               
               
                   
                 CDKN1A 
                 NN 
                 GSK3B 
               
               
                   
                 CDKN1B 
                 NN 
                 CHX10 
               
               
                   
                 CDKN1B 
                 NN 
                 CISH 
               
               
                   
                 CDKN1B 
                 NN 
                 IL3 
               
               
                   
                 CDKN1B 
                 NN 
                 RHOA 
               
               
                   
                 CDKN1B 
                 NN 
                 SOCS3 
               
               
                   
                 CDKN1B 
                 NN 
                 transcription factor 
               
               
                   
                 CDKN2A 
                 NN 
                 CDKN26 
               
               
                   
                 CDKN2B 
                 NN 
                 RBI 
               
               
                   
                 CEBPB 
                 NN 
                 cANP 
               
               
                   
                 CEBPB 
                 NN 
                 CTNNB1 
               
               
                   
                 CEBPG 
                 NN 
                 tumor necrosis factor 
               
               
                   
                 chloroxazone 
                 NN 
                 CYP2E1 
               
               
                   
                 cholesterol 
                 NN 
                 CAV1 
               
               
                   
                 cholesterol 
                 NN 
                 PPARA 
               
               
                   
                 choline-phosphate 
                 NN 
                 RIPK2 
               
               
                   
                 cytidylyltransferase 
               
               
                   
                 CISH 
                 NN 
                 SHOC2 
               
               
                   
                 CNTF 
                 NN 
                 ADCYAP1 
               
               
                   
                 CREB1 
                 NN 
                 CALCA 
               
               
                   
                 CREB1 
                 NN 
                 CREBBP 
               
               
                   
                 CREB1 
                 NN 
                 GSK3B 
               
               
                   
                 CREB1 
                 NN 
                 NAPK11 
               
               
                   
                 CREB1 
                 NN 
                 protein phosphate 1 
               
               
                   
                 CREB1 
                 NN 
                 PTPN1 
               
               
                   
                 CSF1 
                 NN 
                 INPP50 
               
               
                   
                 CSF2 
                 NN 
                 CCR5 
               
               
                   
                 CTNNA1 
                 NN 
                 ITGB1 
               
               
                   
                 CTSS 
                 NN 
                 CST3 
               
               
                   
                 CYCS 
                 NN 
                 ABL1 
               
               
                   
                 CYCS 
                 NN 
                 DAP13 
               
               
                   
                 CYCS 
                 NN 
                 POR 
               
               
                   
                 CYP1A1 
                 NN 
                 estrogens 
               
               
                   
                 CYP2D6 
                 NN 
                 Cyp3a11 
               
               
                   
                 CYP2E1 
                 NN 
                 CYP1A1 
               
               
                   
                 CYP3A4 
                 NN 
                 CYP3A5 
               
               
                   
                 CYP3A4 
                 NN 
                 NET 
               
               
                   
                 DAP 
                 NN 
                 ODC1 
               
               
                   
                 DAPK1 
                 NN 
                 integrin 
               
               
                   
                 deacetylase 
                 NN 
                 HOAC1 
               
               
                   
                 DFFB 
                 NN 
                 UTP 
               
               
                   
                 DIABLO 
                 NN 
                 BIRC4 
               
               
                   
                 DUSPI 
                 NN 
                 RAS small monomeric 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                 E2FI 
                 NN 
                 PRB2 
               
               
                   
                 E2FI 
                 NN 
                 SERPINE1 
               
               
                   
                 E3 
                 NN 
                 DIABLO 
               
               
                   
                 EBP 
                 NN 
                 tumor necrosis factor 
               
               
                   
                 EDN1 
                 NN 
                 BDK 
               
               
                   
                 EDN1 
                 NN 
                 cANP 
               
               
                   
                 EDN1 
                 NN 
                 estradiol 
               
               
                   
                 EDN1 
                 NN 
                 estrosen 
               
               
                   
                 EDN1 
                 NN 
                 LPL 
               
               
                   
                 EDN1 
                 NN 
                 progesterone 
               
               
                   
                 EDNRA 
                 NN 
                 AGTR1 
               
               
                   
                 EGF 
                 NN 
                 ASCL1 
               
               
                   
                 EGF 
                 NN 
                 CLU 
               
               
                   
                 EGF 
                 NN 
                 CTSB 
               
               
                   
                 EGF 
                 NN 
                 GCG 
               
               
                   
                 EGF 
                 NN 
                 IGFBP2 
               
               
                   
                 EGF 
                 NN 
                 HYE 
               
               
                   
                 EGF 
                 NN 
                 TGFB2 
               
               
                   
                 EGFR 
                 NN 
                 ANH 
               
               
                   
                 EGFR 
                 NN 
                 LRTG1 
               
               
                   
                 EGFR 
                 NN 
                 PAKCA 
               
               
                   
                 EGFR 
                 NN 
                 SLC29A1 
               
               
                   
                 EGLN3 
                 NN 
                 HIF1A 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 4 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 EGR1 
                 NN 
                 SP3 
               
               
                   
                 ELA2 
                 NN 
                 ELN 
               
               
                   
                 ELA2 
                 NN 
                 SERPINA3 
               
               
                   
                 ELA2 
                 NN 
                 TINP1 
               
               
                   
                 EPH44 
                 NN 
                 WAP2K4 
               
               
                   
                 EPX 
                 NN 
                 H2O2 
               
               
                   
                 ERBB2 
                 NN 
                 CAV1 
               
               
                   
                 ERBB2 
                 NN 
                 progesterone 
               
               
                   
                 ERBB2 
                 NN 
                 RHOB 
               
               
                   
                 ERK activator 
                 NN 
                 PPARA 
               
               
                   
                 kinase 
               
               
                   
                 F10 
                 NN 
                 protein C (activated) 
               
               
                   
                 F2 
                 NN 
                 PIP2 
               
               
                   
                 FGF1 
                 NN 
                 FIBP 
               
               
                   
                 FGF2 
                 NN 
                 GSK3B 
               
               
                   
                 FGF2 
                 NN 
                 HPSE 
               
               
                   
                 FGF2 
                 NN 
                 NFXBIA 
               
               
                   
                 FGF2 
                 KH 
                 THBS1 
               
               
                   
                 FN1 
                 NN 
                 ACTA2 
               
               
                   
                 FN1 
                 NN 
                 CDC42 
               
               
                   
                 FN1 
                 NN 
                 PLAU 
               
               
                   
                 FOS 
                 NN 
                 CEBPA 
               
               
                   
                 FOS 
                 NN 
                 KLK3 
               
               
                   
                 FOS 
                 NN 
                 Ha+/K+ ATPase 
               
               
                   
                 FOXO1A 
                 NN 
                 PPARG 
               
               
                   
                 FXN 
                 NN 
                 INHBA 
               
               
                   
                 FYN 
                 NN 
                 DUSP1 
               
               
                   
                 GATA1 
                 NN 
                 SPI1 
               
               
                   
                 GCG 
                 NN 
                 DPP4 
               
               
                   
                 GCG 
                 NN 
                 ENTPD2 
               
               
                   
                 GH1 
                 NN 
                 ITIH4 
               
               
                   
                 GHA0 
                 NN 
                 Phosphatidylinositol 
               
               
                   
                   
                   
                 3-Kinase 
               
               
                   
                 GNB2L1 
                 NN 
                 CTNNA2 
               
               
                   
                 GNRH1 
                 NN 
                 HR3C1 
               
               
                   
                 GNRH1 
                 NN 
                 SST 
               
               
                   
                 GPC3 
                 NN 
                 IGF2 
               
               
                   
                 GPI 
                 NN 
                 IGFBP3 
               
               
                   
                 GRB2 
                 NN 
                 PDGFRB 
               
               
                   
                 GRB2 
                 NN 
                 PSKD9 
               
               
                   
                 GRPR 
                 NN 
                 BRS3 
               
               
                   
                 GRPR 
                 NN 
                 NEBR 
               
               
                   
                 GSK3B 
                 NN 
                 CDKN1B 
               
               
                   
                 GSK3B 
                 NN 
                 IRS2 
               
               
                   
                 GSK3B 
                 NN 
                 RPS6KB1 
               
               
                   
                 GSK3B 
                 NN 
                 Nnt 
               
               
                   
                 GSTN1 
                 NN 
                 VAP3K5 
               
               
                   
                 GTP 
                 NN 
                 CALCA 
               
               
                   
                 GTP 
                 NN 
                 POFK1 
               
               
                   
                 HAND2 
                 NN 
                 IL13 
               
               
                   
                 HDAC1 
                 NN 
                 HDAC2 
               
               
                   
                 HDAC4 
                 NN 
                 HEF2A 
               
               
                   
                 HDL 
                 NN 
                 LPL 
               
               
                   
                 HES1 
                 NN 
                 NEUROG3 
               
               
                   
                 HGF 
                 NN 
                 interleukin IL12 
               
               
                   
                 HGF 
                 NN 
                 THBS1 
               
               
                   
                 histone deacetylase 
                 NN 
                 CFTR 
               
               
                   
                 histone deacetylase 
                 NN 
                 E2F4 
               
               
                   
                 HVGA2 
                 NN 
                 CCL2 
               
               
                   
                 HRF4A 
                 NN 
                 NO 
               
               
                   
                 HOXB1 
                 NN 
                 EGR2 
               
               
                   
                 HRAS 
                 NN 
                 RHOB 
               
               
                   
                 HSPA4 
                 NN 
                 caspase 
               
               
                   
                 HSPA4 
                 NN 
                 PKC 
               
               
                   
                 HSPB1 
                 NN 
                 DAKX 
               
               
                   
                 ICAN1 
                 NN 
                 SELL 
               
               
                   
                 ICAN1 
                 NN 
                 TNFRSFG 
               
               
                   
                 IFNG 
                 NN 
                 cytochrome P450 
               
               
                   
                 IFNG 
                 NN 
                 EP300 
               
               
                   
                 IFHG 
                 NN 
                 IL10 
               
               
                   
                 IFHG 
                 NN 
                 IL13 
               
               
                   
                 IFHG 
                 NN 
                 IL17 
               
               
                   
                 IFNG 
                 NN 
                 IL5 
               
               
                   
                 IFNG 
                 NN 
                 PPARG 
               
               
                   
                 IGF1 
                 NN 
                 ADCY2 
               
               
                   
                 IGF1 
                 NN 
                 GDG 
               
               
                   
                 IGF1 
                 NN 
                 HSPCA 
               
               
                   
                 IGF1 
                 NN 
                 ILIF8 
               
               
                   
                 IGF1 
                 NN 
                 LIF 
               
               
                   
                 IGF1 
                 NN 
                 turor necrosis factor 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 5 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 IGF2 
                 NN 
                 H19 
               
               
                   
                 IGFALS 
                 NN 
                 IGF2 
               
               
                   
                 IGFBP1 
                 NN 
                 IGF2 
               
               
                   
                 IGFBP1 
                 NN 
                 IGFBP2 
               
               
                   
                 IGFBP3 
                 NN 
                 chorionic gonadotropin 
               
               
                   
                 IL1 
                 NN 
                 NR3C1 
               
               
                   
                 IL10 
                 NN 
                 lectin 
               
               
                   
                 IL10 
                 NN 
                 NNP9 
               
               
                   
                 IL13 
                 NN 
                 interleukin IL13 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                 IL18 
                 NN 
                 CASP3 
               
               
                   
                 IL18 
                 NN 
                 IL1R1 
               
               
                   
                 IL18BP 
                 NN 
                 IL18 
               
               
                   
                 IL1A 
                 NN 
                 estradiol 
               
               
                   
                 IL1A 
                 NN 
                 PRKCA 
               
               
                   
                 IL1A 
                 NN 
                 thyroid stimulating 
               
               
                   
                   
                   
                 hormone 
               
               
                   
                 IL1B 
                 NN 
                 CCL21 
               
               
                   
                 IL1B 
                 NN 
                 cytochrome P450 
               
               
                   
                 IL1B 
                 NN 
                 EP0 
               
               
                   
                 IL1B 
                 NN 
                 GHRL 
               
               
                   
                 IL1B 
                 NN 
                 HNF4A 
               
               
                   
                 IL1B 
                 NN 
                 NFKB1B 
               
               
                   
                 IL1B 
                 NN 
                 SDC1 
               
               
                   
                 IL1B 
                 NN 
                 SPARC 
               
               
                   
                 IL1B 
                 NN 
                 TIVP3 
               
               
                   
                 IL1F8 
                 NN 
                 ELK 
               
               
                   
                 IL1F8 
                 NN 
                 NFKBIA 
               
               
                   
                 IL1F8 
                 NN 
                 SP3 
               
               
                   
                 IL1R1 
                 NN 
                 PTGS2 
               
               
                   
                 IL1R1 
                 NN 
                 tumor necrosis factor 
               
               
                   
                 IL2 
                 NN 
                 ELA2 
               
               
                   
                 IL2 
                 NN 
                 PAX5 
               
               
                   
                 IL2 
                 NN 
                 TGFB2 
               
               
                   
                 IL4 
                 NN 
                 ALOX5 
               
               
                   
                 IL4 
                 NN 
                 B7H3 
               
               
                   
                 IL4 
                 NN 
                 CXCL9 
               
               
                   
                 IL4 
                 NN 
                 FGF2 
               
               
                   
                 IL4 
                 NN 
                 IFNA1 
               
               
                   
                 IL4 
                 NN 
                 TNPO1 
               
               
                   
                 IL4 
                 NN 
                 TRERF1 
               
               
                   
                 IL4 
                 NN 
                 VIP 
               
               
                   
                 IL5RA 
                 NN 
                 IL5 
               
               
                   
                 IL6 
                 NN 
                 APOE 
               
               
                   
                 IL6 
                 NN 
                 CDKH1A 
               
               
                   
                 IL6 
                 NN 
                 CYP1A2 
               
               
                   
                 IL6 
                 NN 
                 cytochrome P450 
               
               
                   
                 IL6 
                 NN 
                 GFI1B 
               
               
                   
                 IL6 
                 NN 
                 NTP 
               
               
                   
                 IL6 
                 NN 
                 NYB 
               
               
                   
                 IL6 
                 NN 
                 PPARG 
               
               
                   
                 IL6 
                 NN 
                 RB1 
               
               
                   
                 IL6 
                 NN 
                 SELL 
               
               
                   
                 IL6 
                 NN 
                 vitamin D 
               
               
                   
                 INS 
                 NN 
                 alpha2 adrenoceptor 
               
               
                   
                 INS 
                 NN 
                 ARRB1 
               
               
                   
                 INS 
                 NN 
                 cAMP-dependent protein 
               
               
                   
                   
                   
                 kinase, catalyst 
               
               
                   
                 INS 
                 NN 
                 CYP2E1 
               
               
                   
                 INS 
                 NN 
                 DPP4 
               
               
                   
                 INS 
                 NN 
                 epinephrine 
               
               
                   
                 INS 
                 NN 
                 GAL 
               
               
                   
                 INS 
                 NN 
                 glycogen synthase 
               
               
                   
                   
                   
                 kinase 3 
               
               
                   
                 INS 
                 NN 
                 IFNG 
               
               
                   
                 INS 
                 NN 
                 LDL 
               
               
                   
                 INS 
                 NN 
                 PFKFB1 
               
               
                   
                 INS 
                 NN 
                 phosphoenolpyruvate 
               
               
                   
                   
                   
                 carboxykinase 
               
               
                   
                 INS 
                 NN 
                 PLTP 
               
               
                   
                 INS 
                 NN 
                 protein tyrosine 
               
               
                   
                   
                   
                 phosphatase 
               
               
                   
                 INS 
                 NN 
                 PTGIS 
               
               
                   
                 INS 
                 NN 
                 Rho kinase 
               
               
                   
                 INS 
                 NN 
                 RHOA 
               
               
                   
                 INS 
                 NN 
                 TERF2IP 
               
               
                   
                 INS 
                 NN 
                 tumor necrosis factor 
               
               
                   
                 INS 
                 NN 
                 VLDL 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 6 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 interleukin IL12 
                 NN 
                 IL5 
               
               
                   
                 IRAN4 
                 NN 
                 TLR4 
               
               
                   
                 IRF4 
                 NN 
                 BCL6 
               
               
                   
                 IRF4 
                 NN 
                 IFNA1 
               
               
                   
                 IRS2 
                 NN 
                 TRS4 
               
               
                   
                 ITIH4 
                 NN 
                 OCR5 
               
               
                   
                 ITK 
                 NN 
                 CDH1 
               
               
                   
                 JAK1 
                 NN 
                 PTPN6 
               
               
                   
                 JAK2 
                 NN 
                 PTPN6 
               
               
                   
                 JAK2 
                 NN 
                 SOCS3 
               
               
                   
                 JAK2 
                 NN 
                 TYRP1 
               
               
                   
                 JUN 
                 NN 
                 AR 
               
               
                   
                 JUN 
                 NN 
                 CDK2 
               
               
                   
                 JUN 
                 NN 
                 CEBPA 
               
               
                   
                 JUN 
                 NN 
                 CTLA4 
               
               
                   
                 JUN 
                 NN 
                 Na+/K+ ATPase 
               
               
                   
                 JUN 
                 NN 
                 NR3C1 
               
               
                   
                 KIT 
                 NN 
                 PTPN6 
               
               
                   
                 LCP1 
                 NN 
                 ELA2 
               
               
                   
                 LCP1 
                 NN 
                 SERPING1 
               
               
                   
                 LCP1 
                 NN 
                 TFP1 
               
               
                   
                 LEP 
                 NN 
                 CDH1 
               
               
                   
                 LEP 
                 NN 
                 GAL 
               
               
                   
                 LEP 
                 NN 
                 GCG 
               
               
                   
                 LEP 
                 NN 
                 RB1 
               
               
                   
                 LEP 
                 NN 
                 serotonin 
               
               
                   
                 LEP 
                 NN 
                 SST 
               
               
                   
                 ligase 
                 NN 
                 EGFR 
               
               
                   
                 LOX 
                 NN 
                 HRAS 
               
               
                   
                 LPA 
                 NN 
                 cAMP 
               
               
                   
                 LPA 
                 NN 
                 DGPP phosphatase 
               
               
                   
                 LPL 
                 NN 
                 LIPC 
               
               
                   
                 LPL 
                 NN 
                 phosphatidylcholine 
               
               
                   
                 LPL 
                 NN 
                 TG 
               
               
                   
                 LYZ 
                 NN 
                 HIST1H4D 
               
               
                   
                 NADO 
                 NN 
                 TNFRSFIA 
               
               
                   
                 nap kinase 
                 NN 
                 ADRBK1 
               
               
                   
                 nap kinase 
                 NN 
                 NYOD1 
               
               
                   
                 nap kinase 
                 NN 
                 PTEN 
               
               
                   
                 NAP3K1 
                 NN 
                 NAPK3IPI 
               
               
                   
                 NAPK1 
                 NN 
                 BRF1 
               
               
                   
                 NAPK1 
                 NN 
                 CAV1 
               
               
                   
                 NAPK1 
                 NN 
                 CDC2 
               
               
                   
                 NAPK1 
                 NN 
                 DUSP2 
               
               
                   
                 NAPK1 
                 NN 
                 NOS3 
               
               
                   
                 NAPK1 
                 NN 
                 pathway-specific SNAD 
               
               
                   
                   
                   
                 protein 
               
               
                   
                 NAPK1 
                 NN 
                 PTPN6 
               
               
                   
                 NAPK1 
                 NN 
                 RAP16A1 
               
               
                   
                 NAPK10 
                 NN 
                 CDK5 
               
               
                   
                 NAPK14 
                 NN 
                 IT6A4 
               
               
                   
                 NAPK14 
                 NN 
                 Phosphatidyl inositol 
               
               
                   
                   
                   
                 3-kinase 
               
               
                   
                 NAPK14 
                 NN 
                 TXN 
               
               
                   
                 NAPK14 
                 NN 
                 XDH 
               
               
                   
                 NAPK3 
                 NN 
                 EPHB2 
               
               
                   
                 NAPK3 
                 NN 
                 protein phosphatase 2A 
               
               
                   
                 NAPK8 
                 NN 
                 CAV1 
               
               
                   
                 NAPK8 
                 NN 
                 IL4 
               
               
                   
                 NAPK8 
                 NN 
                 NPPA 
               
               
                   
                 NAPK8 
                 NN 
                 PPARA 
               
               
                   
                 NAPK8 
                 NN 
                 protein tyrosine 
               
               
                   
                   
                   
                 phosphatase 
               
               
                   
                 NAPK8 
                 NN 
                 PSEN1 
               
               
                   
                 NAPK8 
                 NN 
                 RARA 
               
               
                   
                 matrix 
                 NN 
                 HYP9 
               
               
                   
                 metalloproteinase 
               
               
                   
                 NHC2TA 
                 NN 
                 IL10 
               
               
                   
                 NNP2 
                 NN 
                 THBS2 
               
               
                   
                 NNP9 
                 NN 
                 gelatin 
               
               
                   
                 HYP9 
                 NN 
                 TIYP3 
               
               
                   
                 NP0 
                 NN 
                 LTF 
               
               
                   
                 NSYB 
                 NN 
                 LTA 
               
               
                   
                 HTBP 
                 NN 
                 EP300 
               
               
                   
                 NUC2 
                 NN 
                 PTGS2 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 7 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 NYC 
                 NN 
                 BCL2 
               
               
                   
                 NYC 
                 NN 
                 CAV1 
               
               
                   
                 NYC 
                 NN 
                 BDKN1A 
               
               
                   
                 NYC 
                 NN 
                 CDKN2B 
               
               
                   
                 NYC 
                 NN 
                 CE8PA 
               
               
                   
                 NYC 
                 NN 
                 EP300 
               
               
                   
                 NYC 
                 NN 
                 IFNA1 
               
               
                   
                 NYC 
                 NN 
                 INHBA 
               
               
                   
                 NYC 
                 NN 
                 NYOD1 
               
               
                   
                 NYC 
                 NN 
                 pathway-specific SNAD 
               
               
                   
                   
                   
                 protein 
               
               
                   
                 NYC 
                 NN 
                 ZBTB16 
               
               
                   
                 NYOD1 
                 NN 
                 RAS small monomeric 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                 NGFB 
                 NN 
                 CDK2 
               
               
                   
                 NGFB 
                 NN 
                 EPAS1 
               
               
                   
                 NGFB 
                 NN 
                 NO 
               
               
                   
                 NGFB 
                 NN 
                 STAT3 
               
               
                   
                 norepinephrine 
                 NN 
                 LEP 
               
               
                   
                 NOS2A 
                 NN 
                 ARG1 
               
               
                   
                 NOS2A 
                 NN 
                 GAPH1 
               
               
                   
                 NOS2A 
                 NN 
                 HNOX1 
               
               
                   
                 NOS2A 
                 NN 
                 RHOA 
               
               
                   
                 NPPA 
                 NN 
                 ANP32A 
               
               
                   
                 NPPA 
                 NN 
                 D9Ngc42e 
               
               
                   
                 NPPA 
                 NN 
                 PRKG1 
               
               
                   
                 NPY 
                 NN 
                 Ca-ATPase 
               
               
                   
                 NPY 
                 NN 
                 GHRH 
               
               
                   
                 NR3C1 
                 NN 
                 NFIC 
               
               
                   
                 NR3C1 
                 NN 
                 Nuclear factor NF 
               
               
                   
                   
                   
                 kappa B 
               
               
                   
                 NTRK1 
                 NN 
                 NGFR 
               
               
                   
                 PARP1 
                 NN 
                 CASP6 
               
               
                   
                 PARP1 
                 NN 
                 cytokine activity 
               
               
                   
                 pathway-specific 
                 NN 
                 EP300 
               
               
                   
                 SNAD protein 
               
               
                   
                 PANR 
                 NN 
                 BCL2 
               
               
                   
                 PAK5 
                 NN 
                 SPI1 
               
               
                   
                 PDPK1 
                 NN 
                 PPP1R13B 
               
               
                   
                 PGR 
                 NN 
                 Nuclear factor NF 
               
               
                   
                   
                   
                 kappa B 
               
               
                   
                 PGR 
                 NN 
                 RELA 
               
               
                   
                 Phosphatidylinositol 
                 NN 
                 CASP3 
               
               
                   
                 3-kinase 
               
               
                   
                 Phosphatidylinositol 
                 NN 
                 CASP9 
               
               
                   
                 3-kinase 
               
               
                   
                 PIK3CA 
                 NN 
                 PTEN 
               
               
                   
                 PKA 
                 NN 
                 CXCL12 
               
               
                   
                 PLA2G18 
                 NN 
                 HTATIP 
               
               
                   
                 PLA2G18 
                 NN 
                 phosphatidylcholine 
               
               
                   
                 PLG 
                 NN 
                 SERPINB5 
               
               
                   
                 PLG 
                 NN 
                 SERPINF2 
               
               
                   
                 PNA 
                 NN 
                 CDK2 
               
               
                   
                 PONC 
                 NN 
                 ascorbic acid 
               
               
                   
                 PONC 
                 NN 
                 doparine D2 receptor 
               
               
                   
                 PPARA 
                 NN 
                 Nuclear factor NF 
               
               
                   
                   
                   
                 kappa B 
               
               
                   
                 PPARA 
                 NN 
                 STAT58 
               
               
                   
                 PPARA 
                 NN 
                 tumor necrosis factor 
               
               
                   
                 PPARG 
                 NN 
                 KLF2 
               
               
                   
                 PPARG 
                 NN 
                 Nuclear factor NF 
               
               
                   
                   
                   
                 kappa B 
               
               
                   
                 PPARG 
                 NN 
                 STAT58 
               
               
                   
                 PRDH1 
                 NN 
                 PAX5 
               
               
                   
                 PRKCA 
                 NN 
                 DGKZ 
               
               
                   
                 PRKCA 
                 NN 
                 protein phosphatase 2A 
               
               
                   
                 PRKCA 
                 NN 
                 PTHLH 
               
               
                   
                 PRKCA 
                 NN 
                 TNFRSF6 
               
               
                   
                 PRL 
                 NN 
                 ANXA5 
               
               
                   
                 PRL 
                 NN 
                 DHT 
               
               
                   
                 protein phosphatase 
                 NN 
                 EGFR 
               
               
                   
                 protein phosphatase 1 
                 NN 
                 RPS6KB1 
               
               
                   
                 protein phosphatase 1 
                 NN 
                 SYK 
               
               
                   
                 protein tyrosine 
                 NN 
                 PRKCD 
               
               
                   
                 phosphatase 
               
               
                   
                 PRV1 
                 NN 
                 ubiquitin 
               
               
                   
                 PSEN1 
                 NN 
                 PSEN2 
               
               
                   
                 PSEN1 
                 NN 
                 SAP kinase 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 8 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 PSND9 
                 NN 
                 CDK6 
               
               
                   
                 PSND9 
                 NN 
                 RAS small monomeric 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                 PTEN 
                 NN 
                 BCAR1 
               
               
                   
                 PTEN 
                 NN 
                 CREB1 
               
               
                   
                 PTEN 
                 NN 
                 Nuclear factor NF 
               
               
                   
                   
                   
                 kappa B 
               
               
                   
                 PTEN 
                 NN 
                 RPS6K 
               
               
                   
                 PTEN 
                 NN 
                 TNFRSF6 
               
               
                   
                 PTEN 
                 NN 
                 tumor necrosis factor 
               
               
                   
                 PTGS2 
                 NN 
                 cANP 
               
               
                   
                 PTGS2 
                 NN 
                 GSK3B 
               
               
                   
                 PTGS2 
                 NN 
                 NUC5AC 
               
               
                   
                 PTGS2 
                 NN 
                 PPARG 
               
               
                   
                 PTH 
                 NN 
                 TNFRSFI1B 
               
               
                   
                 PTHLH 
                 NN 
                 BHLHB2 
               
               
                   
                 PTK2B 
                 NN 
                 BCL2L1 
               
               
                   
                 PTK2B 
                 NN 
                 CHRN1 
               
               
                   
                 PTPN6 
                 NN 
                 receptor signaling 
               
               
                   
                   
                   
                 protein 
               
               
                   
                 RAC1 
                 NN 
                 EFNA1 
               
               
                   
                 RAC1 
                 NN 
                 GDI 
               
               
                   
                 RAC1 
                 NN 
                 GNA12 
               
               
                   
                 RAC1 
                 NN 
                 PTK2 
               
               
                   
                 RAC1 
                 NN 
                 RAC2 
               
               
                   
                 RAF1 
                 NN 
                 CAV1 
               
               
                   
                 RAF1 
                 NN 
                 GAP 
               
               
                   
                 RAF1 
                 NN 
                 NO 
               
               
                   
                 RAF1 
                 NN 
                 RASGRF1 
               
               
                   
                 RARA 
                 NN 
                 CREBBP 
               
               
                   
                 RARA 
                 NN 
                 UBE1L 
               
               
                   
                 RARA 
                 NN 
                 VDR 
               
               
                   
                 RB1 
                 NN 
                 BRCA1 
               
               
                   
                 RB1 
                 NN 
                 COKN2A 
               
               
                   
                 RB1 
                 NN 
                 INHBA 
               
               
                   
                 RB1 
                 NN 
                 NDY2 
               
               
                   
                 RBL1 
                 NN 
                 E2F1 
               
               
                   
                 RBL2 
                 NN 
                 E2F1 
               
               
                   
                 REN 
                 NN 
                 ACE 
               
               
                   
                 REN 
                 NN 
                 RENBP 
               
               
                   
                 RGS4 
                 NN 
                 NOS3 
               
               
                   
                 RHOA 
                 NN 
                 cyclic GNP 
               
               
                   
                 RHOA 
                 NN 
                 myosin phosphatase 
               
               
                   
                 RHOA 
                 NN 
                 PKA 
               
               
                   
                 RPS6KB1 
                 NN 
                 PIK3RI 
               
               
                   
                 SCT 
                 NN 
                 CALCA 
               
               
                   
                 SELL 
                 NN 
                 CD44 
               
               
                   
                 SERPINA1 
                 NN 
                 ELA2 
               
               
                   
                 SERPINE1 
                 NN 
                 protein C (activated) 
               
               
                   
                 SERPINF2 
                 NN 
                 PLAUR 
               
               
                   
                 SKIL 
                 NN 
                 SNAD2 
               
               
                   
                 SLC9A3 
                 NN 
                 SLC9A1 
               
               
                   
                 SNAD3 
                 NN 
                 NYOD1 
               
               
                   
                 SOD2 
                 NN 
                 CAT 
               
               
                   
                 SOD2 
                 NN 
                 PGE 
               
               
                   
                 SPARC 
                 NN 
                 FGF2 
               
               
                   
                 SPI1 
                 NN 
                 GATA2 
               
               
                   
                 SRC 
                 NN 
                 CSK 
               
               
                   
                 src family 
                 NN 
                 LCK 
               
               
                   
                 src family 
                 NN 
                 CSK 
               
               
                   
                 SST 
                 NN 
                 ADCY2 
               
               
                   
                 SST 
                 NN 
                 IAPP 
               
               
                   
                 SST 
                 NN 
                 ILIA 
               
               
                   
                 SST 
                 NN 
                 PPY 
               
               
                   
                 SST 
                 NN 
                 TRH 
               
               
                   
                 STAT3 
                 NN 
                 INHBA 
               
               
                   
                 STAT5A 
                 NN 
                 CDKN1B 
               
               
                   
                 STAT5A 
                 NN 
                 ESR2 
               
               
                   
                 STAT5A 
                 NN 
                 SOCS3 
               
               
                   
                 STAT6 
                 NN 
                 Nuclear factor NF 
               
               
                   
                   
                   
                 kappa B 
               
               
                   
                 sterol 
                 NN 
                 LDLR 
               
               
                   
                 superoxide 
                 NN 
                 NOS3 
               
               
                   
                 dismutase 
               
               
                   
                 SYK 
                 NN 
                 fibrinogen 
               
               
                   
                 TAC1 
                 NN 
                 noradrenaline 
               
               
                   
                 TAC1 
                 NN 
                 NPY 
               
               
                   
                 TAC1 
                 NN 
                 SST 
               
               
                   
                 TEK 
                 NN 
                 ANGPT2 
               
               
                   
                 TERF2IP 
                 NN 
                 GAP 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 9 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 TGFB1 
                 NN 
                 BF 
               
               
                   
                 TGFB1 
                 NN 
                 EGPT 
               
               
                   
                 TGFB1 
                 NN 
                 CA1 
               
               
                   
                 TGFB1 
                 NN 
                 CCHA2 
               
               
                   
                 TGFB1 
                 NN 
                 DCN 
               
               
                   
                 TGFB1 
                 NN 
                 ENTP02 
               
               
                   
                 TGFB1 
                 NN 
                 ESR1 
               
               
                   
                 TGFB1 
                 NN 
                 FOXG18 
               
               
                   
                 TGFB1 
                 NN 
                 GFPT1 
               
               
                   
                 TGFB1 
                 NN 
                 HGF 
               
               
                   
                 TGFB1 
                 NN 
                 IGFBP1 
               
               
                   
                 TGFB1 
                 NN 
                 KITL6 
               
               
                   
                 TGFB1 
                 NN 
                 HYC 
               
               
                   
                 TGFB1 
                 NN 
                 nitric oxide synthase 
               
               
                   
                 TGFB1 
                 NN 
                 NOS2A 
               
               
                   
                 TGFB1 
                 NN 
                 PAX8 
               
               
                   
                 TGFB1 
                 NN 
                 PGF 
               
               
                   
                 TGFB1 
                 NN 
                 PRL 
               
               
                   
                 TGFB1 
                 NN 
                 RBL1 
               
               
                   
                 TGFB1 
                 NN 
                 RELA 
               
               
                   
                 TGFB1 
                 NN 
                 TIE 
               
               
                   
                 TGFB1 
                 NN 
                 TTF2 
               
               
                   
                 thioredoxin 
                 NN 
                 TXN 
               
               
                   
                 reductase (nadph) 
               
               
                   
                 T P1 
                 NN 
                 S100A4 
               
               
                   
                 T P2 
                 NN 
                 GHP3 
               
               
                   
                 TNF 
                 NN 
                 ABCC2 
               
               
                   
                 TNF 
                 NN 
                 ACDC 
               
               
                   
                 TNF 
                 NN 
                 ADCY2 
               
               
                   
                 TNF 
                 NN 
                 ALB 
               
               
                   
                 TNF 
                 NN 
                 ANBP 
               
               
                   
                 TNF 
                 NN 
                 CYP11A1 
               
               
                   
                 TNF 
                 NN 
                 CYP17A1 
               
               
                   
                 TNF 
                 NN 
                 EDNRA 
               
               
                   
                 TNF 
                 NN 
                 FLT1 
               
               
                   
                 TNF 
                 NN 
                 GATA3 
               
               
                   
                 TNF 
                 NN 
                 insulin receptor 
               
               
                   
                 TNF 
                 NN 
                 TRAK1 
               
               
                   
                 TNF 
                 NN 
                 NFXBIB 
               
               
                   
                 TNF 
                 NN 
                 PPARG 
               
               
                   
                 TNF 
                 NN 
                 PROS1 
               
               
                   
                 TNF 
                 NN 
                 protein phosphatase 1 
               
               
                   
                 TNF 
                 NN 
                 REN 
               
               
                   
                 TNF 
                 NN 
                 SFTPC 
               
               
                   
                 TNF 
                 NN 
                 THBS1 
               
               
                   
                 TNFRSF1A 
                 NN 
                 CCL4 
               
               
                   
                 TNFRSF6 
                 NN 
                 CXCL9 
               
               
                   
                 TNFRSF7 
                 NN 
                 TL10 
               
               
                   
                 TP53 
                 NN 
                 ABOC1 
               
               
                   
                 TP53 
                 NN 
                 BIRC3 
               
               
                   
                 TP53 
                 NN 
                 BRCA2 
               
               
                   
                 TP53 
                 NN 
                 CAK complex 
               
               
                   
                 TP53 
                 NN 
                 CDKN1B 
               
               
                   
                 TP53 
                 NN 
                 DAXX 
               
               
                   
                 TP53 
                 NN 
                 FGF2 
               
               
                   
                 TP53 
                 NN 
                 HSPA4 
               
               
                   
                 TP53 
                 NN 
                 NAP4 
               
               
                   
                 TP53 
                 NN 
                 NR3C1 
               
               
                   
                 TP53 
                 NN 
                 PSEN1 
               
               
                   
                 TP53 
                 NN 
                 RAD51 
               
               
                   
                 TP53 
                 NN 
                 telonerase 
               
               
                   
                 TP53 
                 NN 
                 TERT 
               
               
                   
                 TP53 
                 NN 
                 TXNRD1 
               
               
                   
                 turor necrosis 
                 NN 
                 IL5 
               
               
                   
                 factor 
                 NN 
                 NFKBIA 
               
               
                   
                 ubiquitin 
               
               
                   
                 UTP 
                 NN 
                 ATPase 
               
               
                   
                 VDR 
                 NN 
                 PWA 
               
               
                   
                 VEGF 
                 NN 
                 TNFSF15 
               
               
                   
                 VIP 
                 NN 
                 DAP 
               
               
                   
                 VIP 
                 NN 
                 NPY 
               
               
                   
                 WT1 
                 NN 
                 EGFR 
               
               
                   
                 WT1 
                 NN 
                 PVA 
               
               
                   
                 YY1 
                 NN 
                 SREBF1 
               
               
                   
                 ZFPN1 
                 NN 
                 GATA3 
               
               
                   
                   
               
            
           
         
       
     
      Tables 10 to 35 show the PN-type combination (molecule set) of molecules.  
                               TABLE 10                                   Protein A       Protein B                          14-3-3   PN   RAF1           1-phosphetioyl inositol-   PN   HSNB           4-phosphate 5-kinase           5-HT2 receptor   PN   DRD2           ABCB1   PN   IL2           ABL1   PN   BCR           ABL1   PN   HRAS           ABL1   PN   IL7           ABL1   PN   MAP3K1           ABL1   PN   MAPK8           ABL1   PN   NYBBP1A           ABL1   PN   NYC           ABL1   PN   protein tyrosine kinase           ABL1   PN   PTPN1           ABL1   PN   STAT1           ABL1   PN   STAT5A           ABL1   PN   transcription factor           ACE   PN   EDN1           ACE   PN   EGR1           ACE   PN   TGFB1           ACE   PN   TNF           acid phosphatase   PN   KLK3           activin   PN   SNAD2           ACTN1   PN   ABL1           ACVR1   PN   SYAD3           ADANTSL1   PN   FN1           ADCYAP1   PN   JUN           ADD1   PN   LEP           ADD1   PN   SREBF1           ADP   PN   GCG           ADP   PN   HSPA4           ADP   PN   HSPCA           ADP   PN   IL18           ADP   PN   TP53           ADRB3   PN   INS           ADRBK1   PN   NAPK3           AFP   PN   ALB           AGRN   PN   CDC42           AGT   PN   ARG2           AGT   PN   HHOX1           AGT   PN   HTATIP           AGT   PN   LEP           AGT   PN   HAPK9           AGT   PN   PLA2G1B           AGT   PN   PPARG           AGT   PN   PTGIS           AGT   PN   PTH           AGT   PN   PTHLH           AGT   PN   PTK2           AGT   PN   PTPNI1           AGT   PN   RHOA           AGT   PN   SERP1NE1           AGT   PN   SRC           AGTR1   PN   RHOA           AGTR2   PN   NGF8           AGTR2   PN   IP53           AHR   PN   CYP1A1           AKT1   PN   BCL2           AKT1   PN   caspase           AKT1   PN   ERK activator kinase           AKT1   PN   fatty acids           AKT1   PN   FOXD1           AKT1   PN   IGFBP5           AKT1   PN   HAP2K2           AKT1   PN   HR3C1           AKT1   PN   oxygen           AKT1   PN   PIK3R1           AKT1   PN   protein phosphatase 2A           AKT1   PN   RHC8           AKT1   PN   TNFSF6           ALB   PN   FN1           ALB   PN   TL6           ALB   PN   PTGFS           ALB   PN   TGFB1           aldosterone   PN   ADH           alphaVbeta6   PN   NNF9                      
 
     
       
         
           
               
               
               
             
               
                   
                 TABLE 11 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 AVH 
                 PN 
                 IFNG 
               
               
                   
                 aminopeptidase 
                 PN 
                 BDK 
               
               
                   
                 ANGPT2 
                 PN 
                 BDK 
               
               
                   
                 ANGPT4 
                 PN 
                 BDK 
               
               
                   
                 APC 
                 PN 
                 HYC 
               
               
                   
                 APEK1 
                 PN 
                 JUN 
               
               
                   
                 APOE 
                 PN 
                 APP 
               
               
                   
                 APP 
                 PN 
                 IGF1R 
               
               
                   
                 APP 
                 PN 
                 PTGS2 
               
               
                   
                 APPBP1 
                 PN 
                 TP53BP2 
               
               
                   
                 AR 
                 PN 
                 BCL2 
               
               
                   
                 AR 
                 PN 
                 KLK3 
               
               
                   
                 arachidonic acid 
                 PN 
                 CAT 
               
               
                   
                 arachidonic acid 
                 PN 
                 CYP2E1 
               
               
                   
                 arachidonic acid 
                 PN 
                 EGFR 
               
               
                   
                 arachidonic acid 
                 PN 
                 GAP43 
               
               
                   
                 ARG2 
                 PN 
                 AGTR1 
               
               
                   
                 ARHGEF11 
                 PN 
                 PTK2 
               
               
                   
                 ARHGEF7 
                 PN 
                 CDC42 
               
               
                   
                 ARHGEF7 
                 PN 
                 PAK1 
               
               
                   
                 ATF1 
                 PN 
                 CREB1 
               
               
                   
                 ATF1 
                 PN 
                 TGFB1 
               
               
                   
                 ATPase 
                 PN 
                 MAPK6 
               
               
                   
                 ATR 
                 PN 
                 CHEK1 
               
               
                   
                 AVP 
                 PN 
                 AKT1 
               
               
                   
                 BAD 
                 PN 
                 AKT1 
               
               
                   
                 BAD 
                 PN 
                 PKA 
               
               
                   
                 BAG1 
                 PN 
                 HSPA4 
               
               
                   
                 BAX 
                 PN 
                 BCL2L1 
               
               
                   
                 BCAR1 
                 PN 
                 RAC1 
               
               
                   
                 B-cell receptor 
                 PN 
                 PLCG1 
               
               
                   
                 BCL2 
                 PN 
                 IFNG 
               
               
                   
                 BCL2 
                 PN 
                 YDN2 
               
               
                   
                 BCL2 
                 PN 
                 RAS small monomeric 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                 BCL2 
                 PN 
                 RU-486 
               
               
                   
                 BCL2L1 
                 PN 
                 DSIPI 
               
               
                   
                 BCL2L1 
                 PN 
                 MAPK1 
               
               
                   
                 BCL2L1 
                 PN 
                 HFKBIA 
               
               
                   
                 BCL6 
                 PN 
                 TKFRSF5 
               
               
                   
                 BDK 
                 PN 
                 ADH 
               
               
                   
                 BDK 
                 PN 
                 RAC1 
               
               
                   
                 BDK 
                 PN 
                 RHOA 
               
               
                   
                 BDK 
                 PN 
                 SELP 
               
               
                   
                 BDNF 
                 PN 
                 NAPK3 
               
               
                   
                 beta adrenoceptor 
                 PN 
                 GCG 
               
               
                   
                 BGN 
                 PN 
                 RAC1 
               
               
                   
                 BGN 
                 PN 
                 RHOA 
               
               
                   
                 BID 
                 PN 
                 BAX 
               
               
                   
                 BikIk 
                 PN 
                 BCL2L1 
               
               
                   
                 BIRC4 
                 PN 
                 PRSS25 
               
               
                   
                 BIRC4 
                 PN 
                 TGFB1 
               
               
                   
                 BIRC5 
                 PN 
                 AGT 
               
               
                   
                 BIRC7 
                 PN 
                 DIABLO 
               
               
                   
                 blood coagulation 
                 PN 
                 IL6 
               
               
                   
                 factor XII 
               
               
                   
                 BYP15 
                 PN 
                 KITLG 
               
               
                   
                 BYP2 
                 PN 
                 BYP4 
               
               
                   
                 BYP2 
                 PN 
                 SYAD4 
               
               
                   
                 BYP2 
                 PN 
                 TGFB1 
               
               
                   
                 BYP4 
                 PN 
                 CASP3 
               
               
                   
                 BYP4 
                 PN 
                 CASP8 
               
               
                   
                 BRCA1 
                 PN 
                 CASP3 
               
               
                   
                 BRCA1 
                 PN 
                 HAPK3 
               
               
                   
                 C11orf3 
                 PN 
                 BDK 
               
               
                   
                 CAK complex 
                 PN 
                 CCNA2 
               
               
                   
                 CAK complex 
                 PN 
                 CDK4 
               
               
                   
                 CALCA 
                 PN 
                 YAPK1 
               
               
                   
                 CALCA 
                 PN 
                 YAPK3 
               
               
                   
                 CALCA 
                 PN 
                 POYC 
               
               
                   
                 calcineurin 
                 PN 
                 ELK1 
               
               
                   
                 calcineurin 
                 PN 
                 NAPK8 
               
               
                   
                 calcineurin 
                 PN 
                 NEF2A 
               
               
                   
                 calcium 
                 PN 
                 PTGIS 
               
               
                   
                 calcium 
                 PN 
                 TAC1 
               
               
                   
                 calmodulin 
                 PN 
                 GCG 
               
               
                   
                 calmodulin 
                 PN 
                 NAPK1 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                   
                 TABLE 12 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 cAYP 
                 PN 
                 AGT 
               
               
                   
                 cANP 
                 PN 
                 AKT1 
               
               
                   
                 cANP 
                 PN 
                 CXCR4 
               
               
                   
                 cAYP 
                 PN 
                 FGF2 
               
               
                   
                 cAYP 
                 PN 
                 INHBA 
               
               
                   
                 cAYP 
                 PN 
                 KITLG 
               
               
                   
                 cAYP 
                 PN 
                 HPY 
               
               
                   
                 cANP 
                 PN 
                 SST 
               
               
                   
                 carbon tetrachloride 
                 PN 
                 CYP2E1 
               
               
                   
                 CASP1 
                 PN 
                 IL18 
               
               
                   
                 CASP3 
                 PN 
                 BIRC5 
               
               
                   
                 CASP3 
                 PN 
                 TGF1 
               
               
                   
                 CASP3 
                 PN 
                 TAC1 
               
               
                   
                 CASP3 
                 PN 
                 TNF 
               
               
                   
                 CASP7 
                 PN 
                 BCL2 
               
               
                   
                 CASP7 
                 PN 
                 NAP3K1 
               
               
                   
                 CASP8 
                 PN 
                 TNFATP8 
               
               
                   
                 CASP8 
                 PN 
                 TRAF2 
               
               
                   
                 CASP9 
                 PN 
                 BCL2L1 
               
               
                   
                 CASP9 
                 PN 
                 BIRC4 
               
               
                   
                 caspase 
                 PN 
                 IGF1 
               
               
                   
                 caspase 
                 PN 
                 IL8 
               
               
                   
                 CAT 
                 PN 
                 CYCS 
               
               
                   
                 catecholamines 
                 PN 
                 CRH 
               
               
                   
                 catecholamines 
                 PN 
                 LIF 
               
               
                   
                 catecholamines 
                 PN 
                 NPPA 
               
               
                   
                 catenin 
                 PN 
                 AR 
               
               
                   
                 catenin 
                 PN 
                 PTGS2 
               
               
                   
                 catenin 
                 PN 
                 TP53 
               
               
                   
                 CAV1 
                 PN 
                 CD36 
               
               
                   
                 CAV1 
                 PN 
                 ESR1 
               
               
                   
                 CAV1 
                 PN 
                 PKA 
               
               
                   
                 CBL 
                 PN 
                 SH3KBP1 
               
               
                   
                 CCAL1 
                 PN 
                 NAPK1 
               
               
                   
                 CCK 
                 PN 
                 CALCA 
               
               
                   
                 CCK 
                 PN 
                 GCG 
               
               
                   
                 CCK 
                 PN 
                 MAPK1 
               
               
                   
                 CCK 
                 PN 
                 MAPK3 
               
               
                   
                 CCK 
                 PN 
                 NGF3 
               
               
                   
                 CCK 
                 PN 
                 PLA2G1B 
               
               
                   
                 CCK 
                 PN 
                 POVC 
               
               
                   
                 CCK 
                 PN 
                 SST 
               
               
                   
                 CCL2 
                 PN 
                 WAPK8 
               
               
                   
                 CCL21 
                 PN 
                 IL10 
               
               
                   
                 CCL21 
                 PN 
                 WAPK1 
               
               
                   
                 CCL21 
                 PN 
                 TNF 
               
               
                   
                 CCL4 
                 PN 
                 TGF81 
               
               
                   
                 CCL5 
                 PN 
                 CCL2 
               
               
                   
                 CCL5 
                 PN 
                 IL2 
               
               
                   
                 CCL5 
                 PN 
                 IL8 
               
               
                   
                 CCNA2 
                 PN 
                 CDK6 
               
               
                   
                 CCNA2 
                 PN 
                 CDKN16 
               
               
                   
                 CCNB1 
                 PN 
                 CDKN1A 
               
               
                   
                 CCND1 
                 PN 
                 CDK2 
               
               
                   
                 CCND1 
                 PN 
                 CDKN1B 
               
               
                   
                 CCND1 
                 PN 
                 CDX1 
               
               
                   
                 CCND1 
                 PN 
                 E2F1 
               
               
                   
                 CCND1 
                 PN 
                 RASSF1 
               
               
                   
                 CCND1 
                 PN 
                 RPS6KB1 
               
               
                   
                 CCND1 
                 PN 
                 TCF4 
               
               
                   
                 CCND1 
                 PN 
                 TGFB1 
               
               
                   
                 CCND2 
                 PN 
                 CDK4 
               
               
                   
                 CCND2 
                 PN 
                 FOKO3A 
               
               
                   
                 CCND2 
                 PN 
                 INHBA 
               
               
                   
                 CCNE1 
                 PN 
                 CDKN1A 
               
               
                   
                 CCNE1 
                 PN 
                 TP53 
               
               
                   
                 CCR3 
                 PN 
                 CCL11 
               
               
                   
                 CCR5 
                 PN 
                 CXCR3 
               
               
                   
                 CD14 
                 PN 
                 IL4 
               
               
                   
                 CD14 
                 PN 
                 TGFB1 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                   
                 TABLE 13 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 CD24 
                 PN 
                 CD4 
               
               
                   
                 CD28 
                 PN 
                 CHUK 
               
               
                   
                 CD28 
                 PN 
                 IL10 
               
               
                   
                 CD28 
                 PN 
                 TGFB1 
               
               
                   
                 CD28 
                 PN 
                 TNF 
               
               
                   
                 CD28 
                 PN 
                 TNFSF6 
               
               
                   
                 CD4 
                 PN 
                 BCL2L1 
               
               
                   
                 CD4 
                 PN 
                 LCK 
               
               
                   
                 CD44 
                 PN 
                 LFA-1 (integrin) 
               
               
                   
                 CD80 
                 PN 
                 CD28 
               
               
                   
                 CD80 
                 PN 
                 IL10 
               
               
                   
                 CD81 
                 PN 
                 LCK 
               
               
                   
                 CD86 
                 PN 
                 IL10 
               
               
                   
                 CD8A 
                 PN 
                 CCR5 
               
               
                   
                 CD8A 
                 PN 
                 IL10 
               
               
                   
                 CD9 
                 PN 
                 IFNG 
               
               
                   
                 CDC2 
                 PN 
                 HIST2H3C 
               
               
                   
                 CDC2 
                 PN 
                 RPS6KB1 
               
               
                   
                 CDC25A 
                 PN 
                 14-3-3 
               
               
                   
                 CDC25B 
                 PN 
                 CCNA2 
               
               
                   
                 CDC25C 
                 PN 
                 ATR 
               
               
                   
                 CDC25C 
                 PN 
                 CCNA2 
               
               
                   
                 CDC42 
                 PN 
                 AKT1 
               
               
                   
                 CDC42 
                 PN 
                 FegamaRI 
               
               
                   
                 CDC42 
                 PN 
                 NAP3K1 
               
               
                   
                 CDC42 
                 PN 
                 NAP3K4 
               
               
                   
                 CDC42 
                 PN 
                 RPS6KB1 
               
               
                   
                 CDH2 
                 PN 
                 YAPK1 
               
               
                   
                 CDK2 
                 PN 
                 CDC25A 
               
               
                   
                 CDK2 
                 PN 
                 CDK3 
               
               
                   
                 CDK2 
                 PN 
                 CDKN1B 
               
               
                   
                 CDK2 
                 PN 
                 PCNA 
               
               
                   
                 CDK5 
                 PN 
                 CDKN1A 
               
               
                   
                 CDK5 
                 PN 
                 PSND9 
               
               
                   
                 CDK5 
                 PN 
                 TP53 
               
               
                   
                 CDK7 
                 PN 
                 CCNH 
               
               
                   
                 CDKN1A 
                 PN 
                 AHPN/CD437 
               
               
                   
                 CDKN1A 
                 PN 
                 CCKD2 
               
               
                   
                 CDKN1A 
                 PN 
                 Cyp2b20 
               
               
                   
                 CDKN1A 
                 PN 
                 FOS 
               
               
                   
                 CDKN1A 
                 PN 
                 RALGDS 
               
               
                   
                 CDKN1B 
                 PN 
                 CKS1A 
               
               
                   
                 CDKN1B 
                 PN 
                 EGF 
               
               
                   
                 CDKN1A 
                 PN 
                 platelet-derived growth 
               
               
                   
                   
                   
                 factor 
               
               
                   
                 CDKN1B 
                 PN 
                 PSVD9 
               
               
                   
                 CDKN1B 
                 PN 
                 RBL2 
               
               
                   
                 CDKN1B 
                 PN 
                 RPS6K 
               
               
                   
                 CDKN1B 
                 PN 
                 SKP2 
               
               
                   
                 CDT1 
                 PN 
                 GWIH 
               
               
                   
                 CEBPA 
                 PN 
                 acetyltransferase 
               
               
                   
                 CEBPA 
                 PN 
                 SP1 
               
               
                   
                 CEBPB 
                 PN 
                 NR3C1 
               
               
                   
                 CEBPB 
                 PN 
                 TGFB1 
               
               
                   
                 CETP 
                 PN 
                 INS 
               
               
                   
                 CHEK1 
                 PN 
                 TP53 
               
               
                   
                 CHEK2 
                 PN 
                 TP53 
               
               
                   
                 chorionic 
                 PN 
                 TGFA 
               
               
                   
                 gonadotropin 
               
               
                   
                 CIDEA 
                 PN 
                 DFFA 
               
               
                   
                 CIDEB 
                 PN 
                 DFFA 
               
               
                   
                 CLK1 
                 PN 
                 PTCH 
               
               
                   
                 CNTF 
                 PN 
                 LIFR 
               
               
                   
                 CNTF 
                 PN 
                 SOCS3 
               
               
                   
                 CNTFR 
                 PN 
                 LIFR 
               
               
                   
                 COPS5 
                 PN 
                 JUN 
               
               
                   
                 cortisol 
                 PN 
                 GH1 
               
               
                   
                 cortisol 
                 PN 
                 LEP 
               
               
                   
                 CREB1 
                 PN 
                 SOD2 
               
               
                   
                 CRH 
                 PN 
                 GH1 
               
               
                   
                 CRH 
                 PN 
                 PDNC 
               
               
                   
                 CRH 
                 PN 
                 SST 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                   
                 TABLE 14 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 CSF1 
                 PN 
                 COC42 
               
               
                   
                 CSF1 
                 PN 
                 FN1 
               
               
                   
                 CSF1 
                 PN 
                 NYP2 
               
               
                   
                 CSF1 
                 PN 
                 PPARG 
               
               
                   
                 CSF1 
                 PN 
                 PTK2 
               
               
                   
                 CSF1 
                 PN 
                 PTPH6 
               
               
                   
                 CSF1 
                 PN 
                 SHC1 
               
               
                   
                 CSF2 
                 PN 
                 IFHA1 
               
               
                   
                 CSF2 
                 PN 
                 IFNG 
               
               
                   
                 CSF2 
                 PN 
                 IL10 
               
               
                   
                 CSF2 
                 PN 
                 IL4 
               
               
                   
                 CSF2 
                 PN 
                 IL8 
               
               
                   
                 CSF2 
                 PN 
                 PPARG 
               
               
                   
                 CSF2 
                 PN 
                 RARA 
               
               
                   
                 CSF2 
                 PN 
                 STAT1 
               
               
                   
                 CSF3 
                 PN 
                 EGR1 
               
               
                   
                 CSF3 
                 PN 
                 EMI1 
               
               
                   
                 CSF3 
                 PN 
                 MAP2X5 
               
               
                   
                 CSF3 
                 PN 
                 Phosphatidylinesitol 
               
               
                   
                   
                   
                 3-kinase 
               
               
                   
                 CSF3 
                 PN 
                 RUNX1 
               
               
                   
                 CSF3 
                 PN 
                 SOCS1 
               
               
                   
                 CSF3 
                 PN 
                 SOCS3 
               
               
                   
                 CSF3 
                 PN 
                 STAT5A 
               
               
                   
                 CSF3 
                 PN 
                 TGFB1 
               
               
                   
                 CSF3R 
                 PN 
                 STAT1 
               
               
                   
                 CSK 
                 PN 
                 PXN 
               
               
                   
                 CTNNB1 
                 PN 
                 DKK1 
               
               
                   
                 CTNNB1 
                 PN 
                 TCF4 
               
               
                   
                 CTNNB1 
                 PN 
                 TP53 
               
               
                   
                 CTSB 
                 PN 
                 TGFB1 
               
               
                   
                 CTTN 
                 PN 
                 SRC 
               
               
                   
                 CX3CL1 
                 PN 
                 TLiR1 
               
               
                   
                 CX3CR1 
                 PN 
                 CX3CL1 
               
               
                   
                 CXCL1 
                 PN 
                 PKC 
               
               
                   
                 CXCL12 
                 PN 
                 CXCR4 
               
               
                   
                 CXCL12 
                 PN 
                 PTK2B 
               
               
                   
                 CXCL12 
                 PN 
                 RAC1 
               
               
                   
                 CXCL12 
                 PN 
                 TNF 
               
               
                   
                 CXCL13 
                 PN 
                 IL10 
               
               
                   
                 CXCR4 
                 PN 
                 CCL2 
               
               
                   
                 CXCR4 
                 PN 
                 CCR5 
               
               
                   
                 CXCR4 
                 PN 
                 TL8 
               
               
                   
                 cyclase 
                 PN 
                 DRD2 
               
               
                   
                 cyclase 
                 PN 
                 NGF3 
               
               
                   
                 cyclin 
                 PN 
                 CDH1 
               
               
                   
                 cyclin-dependent 
                 PN 
                 BCL2 
               
               
                   
                 protein kinase 
               
               
                   
                 cyclin-dependent 
                 PN 
                 CDK2 
               
               
                   
                 protein kinase 
               
               
                   
                 cyclin-dependent 
                 PN 
                 CDKN1B 
               
               
                   
                 protein kinase 
               
               
                   
                 CYCS 
                 PN 
                 BCL2 
               
               
                   
                 CYP1A1 
                 PN 
                 TFNG 
               
               
                   
                 CYP1A1 
                 PN 
                 TGFB1 
               
               
                   
                 CYP3A4 
                 PN 
                 CYP2E1 
               
               
                   
                 CYRG1 
                 PN 
                 TP53 
               
               
                   
                 cytochrone P450 
                 PN 
                 TNF 
               
               
                   
                 dATP/ATP 
                 PN 
                 CASP9 
               
               
                   
                 DAXX 
                 PN 
                 MAP3K5 
               
               
                   
                 DAXX 
                 PN 
                 MAPK8 
               
               
                   
                 DCE 
                 PN 
                 CYP2E1 
               
               
                   
                 DCN 
                 PN 
                 RAC1 
               
               
                   
                 DCN 
                 PN 
                 RHDA 
               
               
                   
                 DCN 
                 PN 
                 TNF 
               
               
                   
                 DIN 
                 PN 
                 CREB1 
               
               
                   
                 DIN 
                 PN 
                 TGFA 
               
               
                   
                 d-lysine 
                 PN 
                 PLAT 
               
               
                   
                 DNA topoiscaerase 
                 PN 
                 TP53 
               
               
                   
                 (ATP hydrolyzing) 
               
               
                   
                 DNA-dependent 
                 PN 
                 ABL1 
               
               
                   
                 protein kinase 
               
               
                   
                 DNA-dependent 
                 PN 
                 ATN 
               
               
                   
                 protein kinase 
               
               
                   
                 DNASE1L3 
                 PN 
                 PARP1 
               
               
                   
                 DNN1 
                 PN 
                 SRC 
               
               
                   
                 DNN2 
                 PN 
                 CTTN 
               
               
                   
                 DOCK1 
                 PN 
                 TERF2P 
               
               
                   
                 dopemine 
                 PN 
                 PTH 
               
               
                   
                 dopamine D1 receptor 
                 PN 
                 DRD2 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                   
                 TABLE 15 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 DRD2 
                 PN 
                 FOS 
               
               
                   
                 DYL1 
                 PN 
                 AKT1 
               
               
                   
                 DYRK16 
                 PN 
                 MAPK14 
               
               
                   
                 DYRK16 
                 PN 
                 TCF1 
               
               
                   
                 E2 
                 PN 
                 AKT1 
               
               
                   
                 E2 
                 PN 
                 CASP3 
               
               
                   
                 E2F1 
                 PN 
                 BCL2 
               
               
                   
                 E2F1 
                 PN 
                 BCL2L11 
               
               
                   
                 E2F1 
                 PN 
                 CCHA2 
               
               
                   
                 E2F1 
                 PN 
                 CDKN1A 
               
               
                   
                 E2F1 
                 PN 
                 TOPEP1 
               
               
                   
                 E2F1 
                 PN 
                 TP53 
               
               
                   
                 E2F4 
                 PN 
                 RBL2 
               
               
                   
                 EAT2 
                 PN 
                 PGF 
               
               
                   
                 ECE1 
                 PN 
                 EDN1 
               
               
                   
                 EDN1 
                 PN 
                 CAV1 
               
               
                   
                 EDH1 
                 PN 
                 DUSP1 
               
               
                   
                 EDN1 
                 PN 
                 GH1 
               
               
                   
                 EDK1 
                 PN 
                 GNA0 
               
               
                   
                 EDN1 
                 PN 
                 LPA 
               
               
                   
                 EDN1 
                 PN 
                 MAP2K1 
               
               
                   
                 EDN1 
                 PN 
                 MAPK1 
               
               
                   
                 EDN1 
                 PN 
                 MAPK3 
               
               
                   
                 EDN1 
                 PN 
                 MPPA 
               
               
                   
                 EDN1 
                 PN 
                 PTGIS 
               
               
                   
                 EDN1 
                 PN 
                 PTHLH 
               
               
                   
                 EDN1 
                 PN 
                 SRC 
               
               
                   
                 EDN1 
                 PN 
                 src family 
               
               
                   
                 EDN1 
                 PN 
                 SST 
               
               
                   
                 EDNRB 
                 PN 
                 AVP 
               
               
                   
                 effector caspase 
                 PN 
                 PARP1 
               
               
                   
                 EGF 
                 PN 
                 APP 
               
               
                   
                 EGF 
                 PN 
                 AREG 
               
               
                   
                 EGF 
                 PN 
                 cANP 
               
               
                   
                 EGF 
                 PN 
                 CAT 
               
               
                   
                 EGF 
                 PN 
                 DAB2 
               
               
                   
                 EGF 
                 PN 
                 DUSP1 
               
               
                   
                 EGF 
                 PN 
                 EPS15 
               
               
                   
                 EGF 
                 PN 
                 FGF2 
               
               
                   
                 EGF 
                 PN 
                 fibroblast growth factor 
               
               
                   
                 EGF 
                 PN 
                 FST 
               
               
                   
                 EGF 
                 PN 
                 GDI 
               
               
                   
                 EGF 
                 PN 
                 GJA1 
               
               
                   
                 EGF 
                 PN 
                 TNHBA 
               
               
                   
                 EGF 
                 PN 
                 MAP2K2 
               
               
                   
                 EGF 
                 PN 
                 MAP3K1 
               
               
                   
                 EGF 
                 PN 
                 MAPK14 
               
               
                   
                 EGF 
                 PN 
                 PLAU 
               
               
                   
                 EGF 
                 PN 
                 PLAUR 
               
               
                   
                 EGF 
                 PN 
                 PRL 
               
               
                   
                 EGF 
                 PN 
                 PTEN 
               
               
                   
                 EGF 
                 PN 
                 RAC1 
               
               
                   
                 EGF 
                 PN 
                 TERF21P 
               
               
                   
                 EGF 
                 PN 
                 THBS1 
               
               
                   
                 EGFR 
                 PN 
                 catemin 
               
               
                   
                 EGFR 
                 PN 
                 CAN1 
               
               
                   
                 EGFR 
                 PN 
                 DNN1 
               
               
                   
                 EGFR 
                 PN 
                 TGF1R 
               
               
                   
                 EGFR 
                 PN 
                 MAPK14 
               
               
                   
                 EGFR 
                 PN 
                 RAS small nonomeric 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                 EGFR 
                 PN 
                 SHC3 
               
               
                   
                 EGR1 
                 PN 
                 B-cell receptor 
               
               
                   
                 EGR1 
                 PN 
                 JAK2 
               
               
                   
                 EGR1 
                 PN 
                 PPARG 
               
               
                   
                 EGR1 
                 PN 
                 TP53 
               
               
                   
                 EGTA 
                 PN 
                 SYK 
               
               
                   
                 ELA2 
                 PN 
                 CCL2 
               
               
                   
                 ELA2 
                 PN 
                 NNP9 
               
               
                   
                 ELA2 
                 PN 
                 PI3 
               
               
                   
                 ELN 
                 PN 
                 NNP2 
               
               
                   
                 ELN 
                 PN 
                 NNP9 
               
               
                   
                 endothelin 
                 PN 
                 GKRH1 
               
               
                   
                 endothelin 
                 PN 
                 NSN3 
               
               
                   
                 endothelin 
                 PN 
                 NPPA 
               
               
                   
                 endothelin 
                 PN 
                 RAF1 
               
               
                   
                 endothelin- 
                 PN 
                 EDN1 
               
               
                   
                 converting enzyme 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                   
                 TABLE 16 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 endotoxin 
                 PN 
                 PTGIS 
               
               
                   
                 EP300 
                 PN 
                 CTNNB1 
               
               
                   
                 EP300 
                 PN 
                 IL6 
               
               
                   
                 EP300 
                 PN 
                 IRF1 
               
               
                   
                 EP300 
                 PN 
                 NDY2 
               
               
                   
                 EP300 
                 PN 
                 NYOD1 
               
               
                   
                 EP300 
                 PN 
                 PCKA 
               
               
                   
                 EP300 
                 PN 
                 SNAD3 
               
               
                   
                 EPHB1 
                 PN 
                 PXN 
               
               
                   
                 EPO 
                 PN 
                 CISH 
               
               
                   
                 EPO 
                 PN 
                 F2 
               
               
                   
                 EPO 
                 PN 
                 PTPN6 
               
               
                   
                 EPOR 
                 PN 
                 PTPN6 
               
               
                   
                 EPSI5 
                 PN 
                 SNAP25 
               
               
                   
                 EPX 
                 PN 
                 JAK2 
               
               
                   
                 EPX 
                 PN 
                 JUN 
               
               
                   
                 EPX 
                 PN 
                 PRKCA 
               
               
                   
                 EPX 
                 PN 
                 SRC 
               
               
                   
                 ERBB2 
                 PN 
                 CSK 
               
               
                   
                 ERBB2 
                 PN 
                 EP300 
               
               
                   
                 ERBB2 
                 PN 
                 PPARG 
               
               
                   
                 ERBB2 
                 PN 
                 RAF1 
               
               
                   
                 ERBB3 
                 PN 
                 AKT1 
               
               
                   
                 ERK activator 
                 PN 
                 MAP2K6 
               
               
                   
                 kinase 
               
               
                   
                 ESR1 
                 PN 
                 CREB1 
               
               
                   
                 estradiol 
                 PN 
                 EGF 
               
               
                   
                 estradiol 
                 PN 
                 LEP 
               
               
                   
                 estradiol 
                 PN 
                 TGFA 
               
               
                   
                 estrogen 
                 PN 
                 AGT 
               
               
                   
                 ETS1 
                 PN 
                 JUN 
               
               
                   
                 ETS1 
                 PN 
                 HYP1 
               
               
                   
                 ETS1 
                 PN 
                 PDGFA 
               
               
                   
                 ETS1 
                 PN 
                 TGFB1 
               
               
                   
                 F10 
                 PN 
                 LCP1 
               
               
                   
                 F2 
                 PN 
                 OTR 
               
               
                   
                 F2 
                 PN 
                 EGFR 
               
               
                   
                 F2 
                 PN 
                 FN1 
               
               
                   
                 F2 
                 PN 
                 IFNG 
               
               
                   
                 F2 
                 PN 
                 MAPK1 
               
               
                   
                 F2 
                 PN 
                 PRKOD 
               
               
                   
                 F2 
                 PN 
                 PTK2 
               
               
                   
                 F2R 
                 PN 
                 map kinase 
               
               
                   
                 F2R 
                 PN 
                 RPS6K 
               
               
                   
                 F2R 
                 PN 
                 SRC 
               
               
                   
                 F3 
                 PN 
                 FI0 
               
               
                   
                 F3 
                 PN 
                 MAPK3 
               
               
                   
                 F7 
                 PN 
                 IL8 
               
               
                   
                 fatty acids 
                 PN 
                 cANP-dependent protein 
               
               
                   
                   
                   
                 kinase. catalyst 
               
               
                   
                 fatty acids 
                 PN 
                 GCG 
               
               
                   
                 fatty acids 
                 PN 
                 LEP 
               
               
                   
                 fatty acids 
                 PN 
                 PPARA 
               
               
                   
                 FcgamaRI 
                 PN 
                 SYK 
               
               
                   
                 Fe(ii) 
                 PN 
                 CAT 
               
               
                   
                 Fe(iii) 
                 PN 
                 HYOX1 
               
               
                   
                 FGF1 
                 PN 
                 EGF 
               
               
                   
                 FGF1 
                 PN 
                 IL1 
               
               
                   
                 FGF1 
                 PN 
                 SIOOA13 
               
               
                   
                 FGF1 
                 PN 
                 STAT3 
               
               
                   
                 FGF2 
                 PN 
                 AKT1 
               
               
                   
                 FGF2 
                 PN 
                 ALB 
               
               
                   
                 FGF2 
                 PN 
                 CKCL12 
               
               
                   
                 FGF2 
                 PN 
                 F2R 
               
               
                   
                 FGF2 
                 PN 
                 FYN 
               
               
                   
                 FGF2 
                 PN 
                 GJA1 
               
               
                   
                 FGF2 
                 PN 
                 LCP1 
               
               
                   
                 FGF2 
                 PN 
                 LPA 
               
               
                   
                 FGF2 
                 PN 
                 MAPK1 
               
               
                   
                 FGF2 
                 PN 
                 SERPIHE1 
               
               
                   
                 FGF2 
                 PN 
                 SST 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                   
                 TABLE 17 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 FGFR2 
                 PN 
                 GAP43 
               
               
                   
                 fibrin 
                 PN 
                 LCP1 
               
               
                   
                 fibrin 
                 PN 
                 PLG 
               
               
                   
                 fibrinogen 
                 PN 
                 IL1F8 
               
               
                   
                 fibrinogen 
                 PN 
                 PTGIS 
               
               
                   
                 fibrinogen 
                 PN 
                 TNF 
               
               
                   
                 fibroblast growth 
                 PN 
                 NYP1 
               
               
                   
                 factor 
               
               
                   
                 fibroblast growth 
                 PN 
                 NYP3 
               
               
                   
                 factor 
               
               
                   
                 fibroblast growth 
                 PN 
                 PRV1 
               
               
                   
                 fator 
               
               
                   
                 fibroblast growth 
                 PN 
                 SST 
               
               
                   
                 factor 
               
               
                   
                 FLT1 
                 PN 
                 Phosphatidylinositol 
               
               
                   
                   
                   
                 3-kinase 
               
               
                   
                 FLT1 
                 PN 
                 PTK2B 
               
               
                   
                 FLT4 
                 PN 
                 FGF2 
               
               
                   
                 FN1 
                 PN 
                 fibrinogen 
               
               
                   
                 FN1 
                 PN 
                 GRB2 
               
               
                   
                 FN1 
                 PN 
                 LCP1 
               
               
                   
                 FN1 
                 PN 
                 MAPK3 
               
               
                   
                 FN1 
                 PH 
                 MAPK8 
               
               
                   
                 FN1 
                 PH 
                 NMP14 
               
               
                   
                 FN1 
                 PN 
                 NMP2 
               
               
                   
                 FN1 
                 PN 
                 RAF1 
               
               
                   
                 FOSL2 
                 PN 
                 REL6 
               
               
                   
                 FOXA2 
                 PN 
                 HXF4A 
               
               
                   
                 FOXA2 
                 PN 
                 TCF1 
               
               
                   
                 FOXO1A 
                 PN 
                 HYOD1 
               
               
                   
                 FUT7 
                 PN 
                 HAID1 
               
               
                   
                 GAI7 
                 PN 
                 IL6 
               
               
                   
                 GAB1 
                 PN 
                 RPS6K 
               
               
                   
                 GAB2 
                 PN 
                 AKT1 
               
               
                   
                 GABAA receptor 
                 PN 
                 OXT 
               
               
                   
                 GAL 
                 PN 
                 SST 
               
               
                   
                 GAP 
                 PN 
                 RAC1 
               
               
                   
                 GAPD 
                 PN 
                 BCL2 
               
               
                   
                 GAS 
                 PN 
                 GCG 
               
               
                   
                 GAS 
                 PN 
                 MAPK1 
               
               
                   
                 GAS 
                 PN 
                 MAPK3 
               
               
                   
                 GAS 
                 PN 
                 NNP9 
               
               
                   
                 GAS 
                 PN 
                 HTS 
               
               
                   
                 GAS 
                 PN 
                 ODC1 
               
               
                   
                 GAS 
                 PN 
                 SST 
               
               
                   
                 GAS6 
                 PN 
                 AKL 
               
               
                   
                 GAS6 
                 PN 
                 STAT3 
               
               
                   
                 GATA1 
                 PN 
                 GATA4 
               
               
                   
                 GC6 
                 PN 
                 INS 
               
               
                   
                 GC6 
                 PN 
                 SST 
               
               
                   
                 GDHF 
                 PN 
                 AKT1 
               
               
                   
                 gelatin 
                 PN 
                 NNP2 
               
               
                   
                 gelatin 
                 PN 
                 NNP3 
               
               
                   
                 GFAP 
                 PN 
                 ITIH4 
               
               
                   
                 GH1 
                 PN 
                 CISH 
               
               
                   
                 GH1 
                 PN 
                 GH1 
               
               
                   
                 GH1 
                 PN 
                 SOCS3 
               
               
                   
                 GH1 
                 PN 
                 SST 
               
               
                   
                 GH1 
                 PN 
                 TERF2TP 
               
               
                   
                 GH1 
                 PN 
                 TNF 
               
               
                   
                 GH1 
                 PN 
                 TP53 
               
               
                   
                 GHR 
                 PN 
                 IGF1 
               
               
                   
                 GHR 
                 PN 
                 SOCS3 
               
               
                   
                 GHRH 
                 PN 
                 INS 
               
               
                   
                 GHRH 
                 PN 
                 SST 
               
               
                   
                 GHRL 
                 PN 
                 GHRL 
               
               
                   
                 GHRL 
                 PN 
                 IGF1 
               
               
                   
                 GIP 
                 PN 
                 GCG 
               
               
                   
                 GIP 
                 PN 
                 INS 
               
               
                   
                 GIP 
                 PN 
                 SST 
               
               
                   
                 GLI3 
                 PN 
                 GLI2 
               
               
                   
                 glucan 1,4- 
                 PN 
                 INS 
               
               
                   
                 alpha-glucosidase 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                   
                 TABLE 18 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 glucose 
                 PN 
                 BDK 
               
               
                   
                 glucose 
                 PN 
                 FRAP1 
               
               
                   
                 glucose 
                 PN 
                 IGF1 
               
               
                   
                 glucose 
                 PN 
                 LEP 
               
               
                   
                 glucose 
                 PN 
                 MAP2K1 
               
               
                   
                 glucose 
                 PN 
                 MAP3K1 
               
               
                   
                 glucose 
                 PN 
                 MAPK3 
               
               
                   
                 glucose 
                 PN 
                 PRKC0 
               
               
                   
                 glucose 
                 PN 
                 SST 
               
               
                   
                 GLUL 
                 PN 
                 JUN 
               
               
                   
                 GNA12 
                 PN 
                 ARHGEF12 
               
               
                   
                 GNA12 
                 PN 
                 BCL2 
               
               
                   
                 GNA12 
                 PN 
                 JUK 
               
               
                   
                 GNA13 
                 PN 
                 BCL2 
               
               
                   
                 GNA13 
                 PN 
                 CDC42 
               
               
                   
                 GNA13 
                 PN 
                 JUN 
               
               
                   
                 GNA14 
                 PN 
                 SRC 
               
               
                   
                 GNA0 
                 PN 
                 MAP2K6 
               
               
                   
                 GNA0 
                 PN 
                 PLCB1 
               
               
                   
                 GNLY 
                 PN 
                 GCG 
               
               
                   
                 GNRH1 
                 PN 
                 CREB1 
               
               
                   
                 GNRH1 
                 PN 
                 CRH 
               
               
                   
                 GNRH1 
                 PN 
                 MAPK3 
               
               
                   
                 GNRH1 
                 PN 
                 POYC 
               
               
                   
                 GNRH1 
                 PN 
                 PRL 
               
               
                   
                 GNRHR 
                 PN 
                 ADCY2 
               
               
                   
                 GPX1 
                 PN 
                 NOS2A 
               
               
                   
                 GRB2 
                 PN 
                 HRAS 
               
               
                   
                 GRIP1 
                 PN 
                 JUN 
               
               
                   
                 GRLF1 
                 PN 
                 HRAS 
               
               
                   
                 GRLF1 
                 PN 
                 RAF1 
               
               
                   
                 growth factor 
                 PN 
                 ABL1 
               
               
                   
                 activity 
               
               
                   
                 GRP 
                 PN 
                 SST 
               
               
                   
                 GRP 
                 PN 
                 YIP 
               
               
                   
                 GSK3B 
                 PN 
                 MAPK1 
               
               
                   
                 GSN 
                 PN 
                 CFL1 
               
               
                   
                 GTF2B 
                 PN 
                 TBPL1 
               
               
                   
                 GTP 
                 PN 
                 CDC42 
               
               
                   
                 GTP 
                 PN 
                 GHAO 
               
               
                   
                 GTP 
                 PN 
                 HRAS 
               
               
                   
                 GTPase 
                 PN 
                 PAK1 
               
               
                   
                 guanine nucleotide 
                 PN 
                 CDC42 
               
               
                   
                 exchange factor 
               
               
                   
                 GZY8 
                 PN 
                 BCL2 
               
               
                   
                 H1F0 
                 PN 
                 PLG 
               
               
                   
                 H2O2 
                 PN 
                 AKT1 
               
               
                   
                 H2O2 
                 PN 
                 ATV 
               
               
                   
                 H2O2 
                 PN 
                 CYCS 
               
               
                   
                 H2O2 
                 PN 
                 FGF2 
               
               
                   
                 H2O2 
                 PN 
                 MAP2K1 
               
               
                   
                 H2O2 
                 PN 
                 NGFB 
               
               
                   
                 H2O2 
                 PN 
                 PRKCD 
               
               
                   
                 H2O2 
                 PN 
                 PTK2 
               
               
                   
                 H2O2 
                 PN 
                 TXK2 
               
               
                   
                 HDL 
                 PN 
                 APOB 
               
               
                   
                 home 
                 PN 
                 HYOX1 
               
               
                   
                 home 
                 PN 
                 HSPCA 
               
               
                   
                 home oxygenase 
                 PN 
                 CAV1 
               
               
                   
                 (decyclizing) 
               
               
                   
                 HGF 
                 PN 
                 APP 
               
               
                   
                 HGF 
                 PN 
                 MAP2K1 
               
               
                   
                 HGF 
                 PN 
                 MAPK14 
               
               
                   
                 HGF 
                 PN 
                 MAPK3 
               
               
                   
                 HGF 
                 PN 
                 MAPK8 
               
               
                   
                 HGF 
                 PN 
                 RAC1 
               
               
                   
                 HGF 
                 PN 
                 RAF1 
               
               
                   
                 HIF1A 
                 PN 
                 NOS2A 
               
               
                   
                 HIF1A 
                 PN 
                 VEGF 
               
               
                   
                 histanine receptor 
                 PN 
                 AGT 
               
               
                   
                 histone deacetylase 
                 PN 
                 ABCB1 
               
               
                   
                 histone deacetylase 
                 PN 
                 CCNE1 
               
               
                   
                 HLA-A 
                 PN 
                 CD8A 
               
               
                   
                 HYGB1 
                 PN 
                 IL1F8 
               
               
                   
                 HYOK1 
                 PN 
                 HSPA4 
               
               
                   
                 HOYDI3 
                 PN 
                 ODC1 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                   
                 TABLE 19 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 HRAS 
                 PN 
                 AKT1 
               
               
                   
                 HRAS 
                 PN 
                 MAPK1 
               
               
                   
                 HRAS 
                 PN 
                 MAPK3 
               
               
                   
                 HSF1 
                 PN 
                 HSPCA 
               
               
                   
                 HSPCA 
                 PN 
                 DCND1 
               
               
                   
                 HSPCB 
                 PN 
                 TP53 
               
               
                   
                 HTATIP 
                 PN 
                 PTGIS 
               
               
                   
                 HTATIP 
                 PN 
                 RAF1 
               
               
                   
                 HTR2A 
                 PN 
                 PONC 
               
               
                   
                 HTR2A 
                 PN 
                 PRL 
               
               
                   
                 hypoxia-inducible 
                 PN 
                 EPX 
               
               
                   
                 factor 1 
               
               
                   
                 hypoxia-inducible 
                 PN 
                 KOS2A 
               
               
                   
                 factor 1 
               
               
                   
                 ICAN1 
                 PN 
                 CD4 
               
               
                   
                 ICAN1 
                 PN 
                 MAPK3 
               
               
                   
                 ICAN1 
                 PN 
                 RAF1 
               
               
                   
                 ICAN1 
                 PN 
                 IFAP2A 
               
               
                   
                 ICOS 
                 PN 
                 IL5 
               
               
                   
                 ICOS 
                 PN 
                 TNF 
               
               
                   
                 IFI16 
                 PN 
                 TP53 
               
               
                   
                 IFNA1 
                 PN 
                 CISH 
               
               
                   
                 IFNA1 
                 PN 
                 IL10 
               
               
                   
                 IFNG 
                 PN 
                 COKN1A 
               
               
                   
                 IFNG 
                 PN 
                 COKN16 
               
               
                   
                 IFNG 
                 PN 
                 CISH 
               
               
                   
                 IFNG 
                 PN 
                 HA 
               
               
                   
                 IFNG 
                 PN 
                 HGF 
               
               
                   
                 IFNG 
                 PN 
                 IFNB1 
               
               
                   
                 IFNG 
                 PN 
                 INDO 
               
               
                   
                 IFNG 
                 PN 
                 JAK 
               
               
                   
                 IFNG 
                 PN 
                 KLRC1 
               
               
                   
                 IFNG 
                 PN 
                 LANR1 
               
               
                   
                 IFNG 
                 PN 
                 LCP1 
               
               
                   
                 IFNG 
                 PN 
                 MAP2K4 
               
               
                   
                 IFNG 
                 PN 
                 MAPK1 
               
               
                   
                 IFNG 
                 PN 
                 MAPK3 
               
               
                   
                 IFNG 
                 PN 
                 NO 
               
               
                   
                 IFNG 
                 PN 
                 Nuclear factor NF 
               
               
                   
                   
                   
                 kappa B 
               
               
                   
                 IFNG 
                 PN 
                 PKA 
               
               
                   
                 IFNG 
                 PN 
                 PKC 
               
               
                   
                 IFNG 
                 PN 
                 prostaglandin 
               
               
                   
                 IFNG 
                 PN 
                 RAC1 
               
               
                   
                 IFNG 
                 PN 
                 SOCS1 
               
               
                   
                 IFNG 
                 PN 
                 SOCS3 
               
               
                   
                 IFNG 
                 PN 
                 SST 
               
               
                   
                 IFNG 
                 PN 
                 testosterone 
               
               
                   
                 IGBP1 
                 PN 
                 BCL2 
               
               
                   
                 IGF1 
                 PN 
                 AKT1 
               
               
                   
                 TGF1 
                 PN 
                 BDK 
               
               
                   
                 IGF1 
                 PN 
                 EGLAP 
               
               
                   
                 IGF1 
                 PN 
                 FN1 
               
               
                   
                 IGF1 
                 PN 
                 GJA1 
               
               
                   
                 IGF1 
                 PN 
                 PRKCE 
               
               
                   
                 IGF1 
                 PN 
                 STAT3 
               
               
                   
                 IGF1 
                 PN 
                 STAT5A 
               
               
                   
                 IGF1R 
                 PN 
                 PKN 
               
               
                   
                 IGF1R 
                 PN 
                 STAT3 
               
               
                   
                 IGF1R 
                 PN 
                 TNF 
               
               
                   
                 IGF1R 
                 PN 
                 TP53 
               
               
                   
                 IGF1R 
                 PN 
                 tumor necrosis factor 
               
               
                   
                 TGF2 
                 PN 
                 IGFBP3 
               
               
                   
                 IGF2 
                 PN 
                 IGFB1 
               
               
                   
                 IGFBP3 
                 PN 
                 AGT 
               
               
                   
                 IGFBP3 
                 PN 
                 SERPINE1 
               
               
                   
                 IGFBP5 
                 PN 
                 IGF3P6 
               
               
                   
                 THH 
                 PN 
                 PTHLH 
               
               
                   
                 IkappaB kinase 
                 PN 
                 MAPK3 
               
               
                   
                 IL1 
                 PN 
                 AVP 
               
               
                   
                 IL1 
                 PN 
                 CHUK 
               
               
                   
                 IL1 
                 PN 
                 IFNB1 
               
               
                   
                 IL1 
                 PN 
                 IL1R1 
               
               
                   
                 IL1 
                 PN 
                 MAPK3 
               
               
                   
                 IL1 
                 PN 
                 MAPK9 
               
               
                   
                 IL1 
                 PN 
                 PTGIS 
               
               
                   
                 IL1 
                 PN 
                 SST 
               
               
                   
                 IL1 
                 PN 
                 TNFRSFIA 
               
               
                   
                 IL1 
                 PN 
                 VGAK1 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
             
               
                   
                 TABLE 20 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 IL10 
                 PN 
                 CISH 
               
               
                   
                 IL10 
                 PN 
                 INHBA 
               
               
                   
                 IL10 
                 PN 
                 SOCS3 
               
               
                   
                 IL10 
                 PN 
                 STAT3 
               
               
                   
                 IL10 
                 PN 
                 THBS1 
               
               
                   
                 IL10 
                 PN 
                 TNFRSF1A 
               
               
                   
                 IL11 
                 PN 
                 IFNG 
               
               
                   
                 IL11 
                 PN 
                 IL4 
               
               
                   
                 IL11 
                 PN 
                 TNFRSF11B 
               
               
                   
                 IL15 
                 PN 
                 IL7 
               
               
                   
                 IL17 
                 PN 
                 CSF3 
               
               
                   
                 IL17 
                 PN 
                 IL4 
               
               
                   
                 IL18 
                 PN 
                 IL4 
               
               
                   
                 IL18 
                 PN 
                 VCAN1 
               
               
                   
                 IL1A 
                 PN 
                 IFNB1 
               
               
                   
                 IL1A 
                 PN 
                 IL10 
               
               
                   
                 IL1A 
                 PN 
                 PONC 
               
               
                   
                 IL1A 
                 PN 
                 PRL 
               
               
                   
                 IL1A 
                 PN 
                 TGFB1 
               
               
                   
                 IL1A 
                 PN 
                 TNFRSF11B 
               
               
                   
                 IL1B 
                 PN 
                 BCL2 
               
               
                   
                 IL1B 
                 PN 
                 CALCA 
               
               
                   
                 IL1B 
                 PN 
                 GH1 
               
               
                   
                 IL1B 
                 PN 
                 HTATIP 
               
               
                   
                 IL1B 
                 PN 
                 ICAN1 
               
               
                   
                 IL1B 
                 PN 
                 IL13 
               
               
                   
                 IL1B 
                 PN 
                 IL4 
               
               
                   
                 IL1B 
                 PN 
                 MAP2K1 
               
               
                   
                 IL1B 
                 PN 
                 MAP2K6 
               
               
                   
                 IL1B 
                 PN 
                 HHP1 
               
               
                   
                 IL1B 
                 PN 
                 HHP3 
               
               
                   
                 IL1B 
                 PN 
                 NPPA 
               
               
                   
                 IL1B 
                 PN 
                 OSH 
               
               
                   
                 IL1B 
                 PN 
                 PONC 
               
               
                   
                 IL1B 
                 PN 
                 SELE 
               
               
                   
                 IL1B 
                 PN 
                 SPP1 
               
               
                   
                 IL1B 
                 PN 
                 TGFB1 
               
               
                   
                 IL1B 
                 PN 
                 TNFRSF11B 
               
               
                   
                 IL1B 
                 PN 
                 VCAN1 
               
               
                   
                 IL1F8 
                 PN 
                 APP 
               
               
                   
                 IL1F8 
                 PN 
                 COKN1A 
               
               
                   
                 IL1F8 
                 PN 
                 CSF3 
               
               
                   
                 IL1F8 
                 PN 
                 IL10 
               
               
                   
                 IL1F8 
                 PN 
                 IL1R1 
               
               
                   
                 IL1F8 
                 PN 
                 MAP2K1 
               
               
                   
                 IL1F8 
                 PN 
                 NNP3 
               
               
                   
                 IL1F8 
                 PN 
                 NNP9 
               
               
                   
                 IL1F8 
                 PN 
                 OSH 
               
               
                   
                 IL1F8 
                 PN 
                 PPARG 
               
               
                   
                 IL1F8 
                 PN 
                 PSYD9 
               
               
                   
                 IL1F8 
                 PN 
                 SNAD3 
               
               
                   
                 IL1F8 
                 PN 
                 SPP1 
               
               
                   
                 IL1F8 
                 PN 
                 TINP1 
               
               
                   
                 IL2 
                 PN 
                 BCL2 
               
               
                   
                 IL2 
                 PN 
                 CISH 
               
               
                   
                 IL2 
                 PN 
                 HSPA4 
               
               
                   
                 IL2 
                 PN 
                 TFNA1 
               
               
                   
                 IL2 
                 PN 
                 IL2RA 
               
               
                   
                 IL2 
                 PN 
                 JUNB 
               
               
                   
                 IL2 
                 PN 
                 LCK 
               
               
                   
                 IL2 
                 PN 
                 NNP2 
               
               
                   
                 IL2 
                 PN 
                 PTGIS 
               
               
                   
                 IL2 
                 PN 
                 RBL2 
               
               
                   
                 IL2 
                 PN 
                 SOCS3 
               
               
                   
                 IL2 
                 PN 
                 TNFRSF6 
               
               
                   
                 IL2 
                 PN 
                 TP53 
               
               
                   
                 IL21 
                 PN 
                 BCL2 
               
               
                   
                 IL2R6 
                 PN 
                 IL4 
               
               
                   
                 IL2R6 
                 PN 
                 IL7 
               
               
                   
                 IL3 
                 PN 
                 STAT5A 
               
               
                   
                 IL3 
                 PN 
                 TGFB1 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 21 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 IL4 
                 PN 
                 AKT1 
               
               
                   
                 IL4 
                 PN 
                 CISH 
               
               
                   
                 IL4 
                 PN 
                 JAK1 
               
               
                   
                 IL4 
                 PN 
                 JAK2 
               
               
                   
                 IL4 
                 PN 
                 MAPK1 
               
               
                   
                 IL4 
                 PN 
                 NFKBI 
               
               
                   
                 IL4 
                 PN 
                 PPARG 
               
               
                   
                 IL4 
                 PN 
                 PPPIR136 
               
               
                   
                 IL4 
                 PN 
                 RAF1 
               
               
                   
                 IL4 
                 PN 
                 SOCS3 
               
               
                   
                 IL4 
                 PN 
                 STAT5A 
               
               
                   
                 IL4 
                 PN 
                 TNFRSF1A 
               
               
                   
                 IL4R 
                 PN 
                 interleukin IL13 
               
               
                   
                   
                   
                 receptor 
               
               
                   
                 IL5 
                 PN 
                 CISH 
               
               
                   
                 IL5 
                 PN 
                 HRAS 
               
               
                   
                 IL5 
                 PN 
                 IL10 
               
               
                   
                 IL5 
                 PN 
                 MAPK1 
               
               
                   
                 IL6 
                 PN 
                 APO8 
               
               
                   
                 IL6 
                 PN 
                 AYP 
               
               
                   
                 IL6 
                 PN 
                 BCL2 
               
               
                   
                 IL6 
                 PN 
                 BMP6 
               
               
                   
                 IL6 
                 PN 
                 BYP7 
               
               
                   
                 IL6 
                 PN 
                 CO59 
               
               
                   
                 IL6 
                 PN 
                 CISH 
               
               
                   
                 IL6 
                 PN 
                 HDL 
               
               
                   
                 IL6 
                 PN 
                 ILEST 
               
               
                   
                 IL6 
                 PN 
                 interleukin-6 receptor 
               
               
                   
                 IL6 
                 PN 
                 nap kinase 
               
               
                   
                 IL6 
                 PN 
                 NVP9 
               
               
                   
                 IL6 
                 PN 
                 NFKBI 
               
               
                   
                 IL6 
                 PN 
                 PIAS1 
               
               
                   
                 IL6 
                 PN 
                 PIAS3 
               
               
                   
                 IL6 
                 PN 
                 RAF1 
               
               
                   
                 IL6 
                 PN 
                 RPS6K 
               
               
                   
                 IL6 
                 PN 
                 SHOC2 
               
               
                   
                 IL6 
                 PN 
                 STL1 
               
               
                   
                 IL6 
                 PN 
                 SOCS1 
               
               
                   
                 IL6 
                 PN 
                 SOCS2 
               
               
                   
                 IL6 
                 PN 
                 SOCS3 
               
               
                   
                 IL6 
                 PN 
                 SST 
               
               
                   
                 IL6 
                 PN 
                 TNF-alpha receptor 
               
               
                   
                 IL6 
                 PN 
                 VIP 
               
               
                   
                 IL7 
                 PN 
                 IFNG 
               
               
                   
                 IL7 
                 PN 
                 IL6 
               
               
                   
                 IL8 
                 PN 
                 BCL2 
               
               
                   
                 IL8 
                 PN 
                 IL1R1 
               
               
                   
                 IL8 
                 PN 
                 NFKBIA 
               
               
                   
                 IL8 
                 PN 
                 RHOA 
               
               
                   
                 IL9 
                 PN 
                 CISH 
               
               
                   
                 IL9 
                 PN 
                 IFNG 
               
               
                   
                 IL9 
                 PN 
                 SOCS3 
               
               
                   
                 IL9 
                 PN 
                 STAT5A 
               
               
                   
                 ILF 
                 PN 
                 SOCS3 
               
               
                   
                 ILK 
                 PN 
                 NAFK1 
               
               
                   
                 INHBA 
                 PN 
                 INS 
               
               
                   
                 INHBA 
                 PN 
                 MAPK14 
               
               
                   
                 INHBA 
                 PN 
                 MAPK3 
               
               
                   
                 inositol 
                 PN 
                 ADCY2 
               
               
                   
                 phospholipids 
               
               
                   
                 INS 
                 PN 
                 ABL1 
               
               
                   
                 INS 
                 PN 
                 ADRA1A 
               
               
                   
                 INS 
                 PN 
                 adrenoceptor 
               
               
                   
                 INS 
                 PN 
                 AGT 
               
               
                   
                 INS 
                 PN 
                 AGIR2 
               
               
                   
                 INS 
                 PN 
                 amylase 
               
               
                   
                 INS 
                 PN 
                 APOA1 
               
               
                   
                 INS 
                 PN 
                 CALCA 
               
               
                   
                 INS 
                 PN 
                 CRH 
               
               
                   
                 INS 
                 PN 
                 CRYAB 
               
               
                   
                 INS 
                 PN 
                 DNH1 
               
               
                   
                 INS 
                 PN 
                 DUSP1 
               
               
                   
                 INS 
                 PN 
                 FOS 
               
               
                   
                 INS 
                 PN 
                 GNAD 
               
               
                   
                 INS 
                 PN 
                 GRB14 
               
               
                   
                 INS 
                 PN 
                 GSK38 
               
               
                   
                 INS 
                 PN 
                 HSPCA 
               
               
                   
                 INS 
                 PN 
                 IAPP 
               
               
                   
                 INS 
                 PN 
                 IGFBP3 
               
               
                   
                 INS 
                 PN 
                 IL1 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 22 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 INS 
                 PN 
                 INPP50 
               
               
                   
                 INS 
                 PN 
                 INPPL1 
               
               
                   
                 INS 
                 PN 
                 JUN 
               
               
                   
                 INS 
                 PN 
                 LEP 
               
               
                   
                 INS 
                 PN 
                 MAPK11 
               
               
                   
                 INS 
                 PN 
                 MYC 
               
               
                   
                 INS 
                 PN 
                 NFKBIA 
               
               
                   
                 INS 
                 PN 
                 NOS3 
               
               
                   
                 INS 
                 PN 
                 OGT 
               
               
                   
                 INS 
                 PN 
                 opioid receptor 
               
               
                   
                 INS 
                 PN 
                 PDE3B 
               
               
                   
                 INS 
                 PN 
                 PIK3R1 
               
               
                   
                 INS 
                 PN 
                 PIK3R2 
               
               
                   
                 INS 
                 PN 
                 PPARA 
               
               
                   
                 INS 
                 PN 
                 PRKCD 
               
               
                   
                 INS 
                 PN 
                 progesterone 
               
               
                   
                 INS 
                 PN 
                 PTP16 
               
               
                   
                 INS 
                 PN 
                 PTPRF 
               
               
                   
                 INS 
                 PN 
                 RAB4A 
               
               
                   
                 INS 
                 PN 
                 RAC1 
               
               
                   
                 INS 
                 PN 
                 RAPGEF1 
               
               
                   
                 INS 
                 PN 
                 RHOO 
               
               
                   
                 INS 
                 PN 
                 SCN10A 
               
               
                   
                 INS 
                 PN 
                 SERPINE1 
               
               
                   
                 INS 
                 PN 
                 SGK 
               
               
                   
                 INS 
                 PN 
                 SOCS3 
               
               
                   
                 INS 
                 PN 
                 SOCS6 
               
               
                   
                 INS 
                 PN 
                 SP1 
               
               
                   
                 INS 
                 PN 
                 SST 
               
               
                   
                 INS 
                 PN 
                 TAT 
               
               
                   
                 INS 
                 PN 
                 TNFRSF6 
               
               
                   
                 INS 
                 PN 
                 TP53INP1 
               
               
                   
                 INS 
                 PN 
                 TREP10 
               
               
                   
                 INS 
                 PN 
                 TSC1 
               
               
                   
                 INS 
                 PN 
                 VANP2 
               
               
                   
                 INS 
                 PN 
                 VANP3 
               
               
                   
                 insulin receptor 
                 PN 
                 AKT1 
               
               
                   
                 insulin receptor 
                 PN 
                 ERS1 
               
               
                   
                 insulin receptor 
                 PN 
                 KLK3 
               
               
                   
                 insulin receptor 
                 PN 
                 SOCS3 
               
               
                   
                 integrin 
                 PN 
                 F3 
               
               
                   
                 integrin 
                 PN 
                 MAPK3 
               
               
                   
                 interleukin IL12 
                 PN 
                 IL13 
               
               
                   
                 interleukin IL12 
                 PN 
                 IL4 
               
               
                   
                 interleukin IL12 
                 PN 
                 MAPK1 
               
               
                   
                 interleukin IL12 
                 PN 
                 MAPK8 
               
               
                   
                 interleukin IL12 
                 PN 
                 IL10 
               
               
                   
                 receptor 
               
               
                   
                 interleukin IL23 
                 PN 
                 IFNG 
               
               
                   
                 interleukin-1 
                 PN 
                 IFNG 
               
               
                   
                 receptor ligand 
               
               
                   
                 interleukin-1 
                 PN 
                 VCAY1 
               
               
                   
                 receptor ligand 
               
               
                   
                 LOGAP1 
                 PN 
                 RAC1 
               
               
                   
                 IRF1 
                 PN 
                 IRF2 
               
               
                   
                 IRS1 
                 PN 
                 AKT1 
               
               
                   
                 IRS1 
                 PN 
                 PPP1R138 
               
               
                   
                 IRS1 
                 PN 
                 RPS6KB1 
               
               
                   
                 IRS2 
                 PN 
                 AKT1 
               
               
                   
                 IRS2 
                 PN 
                 FRAP1 
               
               
                   
                 isoproterenol 
                 PN 
                 GCG 
               
               
                   
                 ITGB1 
                 PN 
                 SREBF1 
               
               
                   
                 ITIH4 
                 PN 
                 CCL5 
               
               
                   
                 ITIHA 
                 PN 
                 MAPK14 
               
               
                   
                 JVL 
                 PN 
                 CDKN1A 
               
               
                   
                 JAK 
                 PN 
                 SOCS3 
               
               
                   
                 JAK2 
                 PN 
                 CISH 
               
               
                   
                 JAK2 
                 PN 
                 IFNA1 
               
               
                   
                 JAK2 
                 PN 
                 MAPK8 
               
               
                   
                 JAK2 
                 PN 
                 PRKC0 
               
               
                   
                 JAK3 
                 PN 
                 JAK2 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 23 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 JAK 
                 PN 
                 DUSP1 
               
               
                   
                 JUN 
                 PN 
                 CEBPG 
               
               
                   
                 JUN 
                 PN 
                 OKK1 
               
               
                   
                 JUN 
                 PN 
                 EBP 
               
               
                   
                 JUN 
                 PN 
                 GSK3B 
               
               
                   
                 JUN 
                 PN 
                 NR4A1 
               
               
                   
                 JUN 
                 PN 
                 Phosphatidylinositol 
               
               
                   
                   
                   
                 3-kinase 
               
               
                   
                 JUN 
                 PN 
                 RARA 
               
               
                   
                 JUN 
                 PN 
                 SO02 
               
               
                   
                 JUN 
                 PN 
                 SP11 
               
               
                   
                 JUK8 
                 PN 
                 NPPA 
               
               
                   
                 KDR 
                 PN 
                 AKT1 
               
               
                   
                 KDR 
                 PN 
                 CAV1 
               
               
                   
                 KDR 
                 PN 
                 HSPCA 
               
               
                   
                 KDR 
                 PN 
                 TGFB1 
               
               
                   
                 kininogenase 
                 PN 
                 BDK 
               
               
                   
                 KIT 
                 PN 
                 BCL2L1 
               
               
                   
                 KIT 
                 PN 
                 MYC 
               
               
                   
                 KITLG 
                 PN 
                 AKT1 
               
               
                   
                 KITLG 
                 PN 
                 BCL2L1 
               
               
                   
                 KITLG 
                 PN 
                 CISH 
               
               
                   
                 KITLG 
                 PN 
                 IL8 
               
               
                   
                 KITLG 
                 PN 
                 LYN 
               
               
                   
                 KITLG 
                 PN 
                 SRC 
               
               
                   
                 KLK3 
                 PN 
                 A2Y 
               
               
                   
                 KLRA1 
                 PN 
                 NIC8 
               
               
                   
                 KRAS2 
                 PN 
                 AKT1 
               
               
                   
                 LAN 
                 PN 
                 IL10 
               
               
                   
                 laminin 
                 PN 
                 NYP2 
               
               
                   
                 laminin 
                 PN 
                 PLAU 
               
               
                   
                 laminin 
                 PN 
                 PONC 
               
               
                   
                 LBP 
                 PN 
                 CD14 
               
               
                   
                 LCK 
                 PN 
                 MAPK1 
               
               
                   
                 LCP1 
                 PN 
                 A2Y 
               
               
                   
                 LCP1 
                 PN 
                 MP3 
               
               
                   
                 LCP2 
                 PN 
                 PLCG1 
               
               
                   
                 LDL 
                 PN 
                 ALB 
               
               
                   
                 LDL 
                 PN 
                 YAPK14 
               
               
                   
                 LDL 
                 PN 
                 RHOA 
               
               
                   
                 LDL 
                 PN 
                 SELE 
               
               
                   
                 LEP 
                 PN 
                 CISH 
               
               
                   
                 LEP 
                 PN 
                 POYC 
               
               
                   
                 LEP 
                 PN 
                 SOCS3 
               
               
                   
                 LEP 
                 PN 
                 STAT3 
               
               
                   
                 LEP 
                 PN 
                 TGFB1 
               
               
                   
                 LGALS1 
                 PN 
                 PTPRC 
               
               
                   
                 LIF 
                 PN 
                 CISH 
               
               
                   
                 LIF 
                 PN 
                 MAPK8 
               
               
                   
                 linoleic acid 
                 PN 
                 EGFR 
               
               
                   
                 lipid 
                 PN 
                 PPARA 
               
               
                   
                 Lipids 
                 PN 
                 AKT1 
               
               
                   
                 Lipopolysaccharide 
                 PN 
                 IL10 
               
               
                   
                 LOC365454 
                 PN 
                 RAC1 
               
               
                   
                 LPA 
                 PN 
                 CAT 
               
               
                   
                 LPA 
                 PN 
                 DTR 
               
               
                   
                 LPA 
                 PN 
                 EGFR 
               
               
                   
                 LPA 
                 PN 
                 GAB1 
               
               
                   
                 LPA 
                 PN 
                 PLG 
               
               
                   
                 LPA 
                 PN 
                 PTPN11 
               
               
                   
                 LPL 
                 PN 
                 LDLR 
               
               
                   
                 LPL 
                 PN 
                 PRL 
               
               
                   
                 LPS 
                 PN 
                 HTATIP 
               
               
                   
                 LPS 
                 PN 
                 IFNA1 
               
               
                   
                 LPS 
                 PN 
                 IFNG 
               
               
                   
                 LPS 
                 PN 
                 IL10 
               
               
                   
                 LPS 
                 PN 
                 IL6 
               
               
                   
                 LPS 
                 PN 
                 MAPK9 
               
               
                   
                 LPS 
                 PN 
                 SPP1 
               
               
                   
                 LPS 
                 PN 
                 TGFB1 
               
               
                   
                 LRBA 
                 PN 
                 TP53 
               
               
                   
                 LRP1 
                 PN 
                 VEGF 
               
               
                   
                 LTB 
                 PN 
                 PPARA 
               
               
                   
                 LTB4 
                 PN 
                 IL4 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 24 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 Luteinizing hormone 
                 PN 
                 IL1B 
               
               
                   
                 LYN 
                 PN 
                 MAP2K7 
               
               
                   
                 LYN 
                 PN 
                 protein phosphatase 1 
               
               
                   
                 MAG-1 (integrin) 
                 PN 
                 CAT 
               
               
                   
                 MADD 
                 PN 
                 TNF 
               
               
                   
                 MAH 
                 PN 
                 CYP2E1 
               
               
                   
                 map kinase 
                 PN 
                 CALCA 
               
               
                   
                 map kinase 
                 PN 
                 CREB1 
               
               
                   
                 map kinase 
                 PN 
                 DUSP1 
               
               
                   
                 map kinase 
                 PN 
                 HSPA4 
               
               
                   
                 map kinase 
                 PN 
                 SELL 
               
               
                   
                 map kinase 
                 PN 
                 SOCS3 
               
               
                   
                 map kinase 
                 PN 
                 TH 
               
               
                   
                 MAP kinase kinase 
                 PN 
                 TERF2IP 
               
               
                   
                 kinase 
               
               
                   
                 MAP2K1 
                 PN 
                 CDG2PN 
               
               
                   
                 MAP2K1 
                 PN 
                 MAPK14 
               
               
                   
                 MAP2K1 
                 PN 
                 MAPK8 
               
               
                   
                 MAP2K1 
                 PN 
                 SNAD2 
               
               
                   
                 MAP2K2 
                 PN 
                 MAPK14 
               
               
                   
                 MAP2K2 
                 PN 
                 MAPK8 
               
               
                   
                 MAP2K3 
                 PN 
                 MAPK1 
               
               
                   
                 MAP3K1 
                 PN 
                 AXT1 
               
               
                   
                 MAP3K1 
                 PN 
                 DUSP1 
               
               
                   
                 MAP3K1 
                 PN 
                 MAP2K4 
               
               
                   
                 MAP3K1 
                 PN 
                 MAPK9 
               
               
                   
                 MAP3K1 
                 PN 
                 THFRSF6 
               
               
                   
                 MAP3K10 
                 PN 
                 MAP2K4 
               
               
                   
                 MAP3K3 
                 PN 
                 CHUK 
               
               
                   
                 MAP3K5 
                 PN 
                 CDC25A 
               
               
                   
                 MAP3K5 
                 PN 
                 TP53 
               
               
                   
                 MAPK1 
                 PN 
                 ADRBK1 
               
               
                   
                 MAPK1 
                 PN 
                 AR 
               
               
                   
                 MAPK1 
                 PN 
                 ATF2 
               
               
                   
                 MAPK1 
                 PN 
                 CASP3 
               
               
                   
                 MAPK1 
                 PN 
                 CDK4 
               
               
                   
                 MAPK1 
                 PN 
                 CISH 
               
               
                   
                 MAPK1 
                 PN 
                 DEFB4 
               
               
                   
                 MAPK1 
                 PN 
                 DUSP1 
               
               
                   
                 MAPK1 
                 PN 
                 DUSP4 
               
               
                   
                 MAPK1 
                 PN 
                 HEF1A 
               
               
                   
                 MAPK1 
                 PN 
                 MLC1 
               
               
                   
                 MAPK1 
                 PN 
                 MYP2 
               
               
                   
                 MAPK1 
                 PN 
                 nadph oxidase 
               
               
                   
                 MAPK1 
                 PN 
                 PLAUR 
               
               
                   
                 MAPK1 
                 PN 
                 protein-glutamine gamre- 
               
               
                   
                   
                   
                 glutanyltransferase 
               
               
                   
                 MAPK1 
                 PN 
                 RPS6 
               
               
                   
                 MAPK1 
                 PN 
                 SOCS1 
               
               
                   
                 MAPK14 
                 PN 
                 CDKH1A 
               
               
                   
                 MAPK14 
                 PN 
                 HSPA4 
               
               
                   
                 MAPK14 
                 PN 
                 nadph oxidase 
               
               
                   
                 MAPK14 
                 PN 
                 NOS3 
               
               
                   
                 MAPK14 
                 PN 
                 NPPA 
               
               
                   
                 MAPK14 
                 PN 
                 PPARA 
               
               
                   
                 MAPK14 
                 PN 
                 PPARG 
               
               
                   
                 MAPK14 
                 PN 
                 SWD3 
               
               
                   
                 MAPK3 
                 PN 
                 CDKN1B 
               
               
                   
                 MAPK3 
                 PN 
                 dual-specificity 
               
               
                   
                   
                   
                 protein phosphatase 
               
               
                   
                 MAPK3 
                 PN 
                 FOSB 
               
               
                   
                 MAPK3 
                 PN 
                 GAB1 
               
               
                   
                 MAPK3 
                 PN 
                 MAPKAP1 
               
               
                   
                 MAPK3 
                 PN 
                 MCF1 
               
               
                   
                 MAPK3 
                 PN 
                 PRKCE 
               
               
                   
                 MAPK3 
                 PN 
                 PTGS2 
               
               
                   
                 MAPK3 
                 PN 
                 SAP kinase 
               
               
                   
                 MAPK7 
                 PN 
                 MAP2K2 
               
               
                   
                 MAPK7 
                 PN 
                 MAPK3 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 25 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 MAPK8 
                 PN 
                 CAT 
               
               
                   
                 MAPK8 
                 PN 
                 CDKN1A 
               
               
                   
                 MAPK8 
                 PN 
                 DUSP1 
               
               
                   
                 MAPK8 
                 PN 
                 HSP81 
               
               
                   
                 MAPK8 
                 PN 
                 IkappaB kinase 
               
               
                   
                 MAPK8 
                 PN 
                 JKK 
               
               
                   
                 MAPK8 
                 PN 
                 MPPB 
               
               
                   
                 MAPK8 
                 PN 
                 PARP1 
               
               
                   
                 MAPK8 
                 PN 
                 PKC 
               
               
                   
                 MAPK8 
                 PN 
                 PPN1L 
               
               
                   
                 MAPK8 
                 PN 
                 protein phosphatase 2A 
               
               
                   
                 MAPK8 
                 PN 
                 SYAD2 
               
               
                   
                 MAPK8 
                 PN 
                 SYCA 
               
               
                   
                 MAPK8 
                 PN 
                 SOD2 
               
               
                   
                 MAPK8 
                 PN 
                 ATF2 
               
               
                   
                 MAPK9 
                 PN 
                 SCL2L1 
               
               
                   
                 MAPK9 
                 PN 
                 MAPK8 
               
               
                   
                 MAPK9 
                 PN 
                 SNAD4 
               
               
                   
                 MAPKAP1 
                 PN 
                   OX1 
               
               
                   
                 matrix 
                 PN 
                   P2 
               
               
                   
                 metalloproteinase 
               
               
                   
                 MAX 
                 PN 
                 NXI1 
               
               
                   
                 MCF2 
                 PN 
                 CDC42 
               
               
                   
                 MCF2 
                 PN 
                 MAPK1 
               
               
                   
                 MCF2L 
                 PN 
                 CDC42 
               
               
                   
                 MCN7 
                 PN 
                 NC 2 
               
               
                   
                 MCP 
                 PN 
                 TGFB1 
               
               
                   
                 MDA 
                 PN 
                 CAT 
               
               
                   
                 MDK2 
                 PN 
                 E2F1 
               
               
                   
                 MDK2 
                 PN 
                 HIF1A 
               
               
                   
                 MDK2 
                 PN 
                 MDH4 
               
               
                   
                 MEN1 
                 PN 
                 RUNX2 
               
               
                   
                 MET 
                 PN 
                 PRL 
               
               
                   
                 MIF 
                 PN 
                 src family 
               
               
                   
                 MITF 
                 PN 
                 MAPK14 
               
               
                   
                 MKNK1 
                 PN 
                 EIF4EBP1 
               
               
                   
                 MLN 
                 PN 
                 INS 
               
               
                   
                 MNP13 
                 PN 
                 TINP1 
               
               
                   
                 MYP14 
                 PN 
                 VEGF 
               
               
                   
                 MYP2 
                 PN 
                 map kinase 
               
               
                   
                 MYP2 
                 PN 
                 PTK2 
               
               
                   
                 MYP2 
                 PN 
                 TINP1 
               
               
                   
                 MYP3 
                 PN 
                 FGF7 
               
               
                   
                 MYP3 
                 PN 
                 JUN 
               
               
                   
                 MYP3 
                 PN 
                 TIYP1 
               
               
                   
                 MOS 
                 PN 
                 RPS6K 
               
               
                   
                 MSIB 
                 PN 
                 EGFR 
               
               
                   
                 MSTI 
                 PN 
                 DFFA 
               
               
                   
                 MTBP 
                 PN 
                 IP53 
               
               
                   
                 MUC4 
                 PN 
                 SNAD2 
               
               
                   
                 MYC 
                 PN 
                 CD 2A 
               
               
                   
                 MYC 
                 PN 
                 GAPD 
               
               
                   
                 NYC 
                 PN 
                 GATA1 
               
               
                   
                 NYC 
                 PN 
                 histone 
               
               
                   
                 NYC 
                 PN 
                 KRT18 
               
               
                   
                 NYC 
                 PN 
                 NFKB1A 
               
               
                   
                 NYC 
                 PN 
                 NSEP1 
               
               
                   
                 NYC 
                 PN 
                 phosphopyruvate 
               
               
                   
                   
                   
                 hydratase 
               
               
                   
                 NYC 
                 PN 
                 TFAP2A 
               
               
                   
                 NYCN 
                 PN 
                 NGFB 
               
               
                   
                 NYOD1 
                 PN 
                 TGFB1 
               
               
                   
                 NCF1 
                 PN 
                 MAPK1 
               
               
                   
                 NCSTN 
                 PN 
                 APP 
               
               
                   
                 nerve growth factor 
                 PN 
                 TP53 
               
               
                   
                 receptor ligand 
               
               
                   
                 NF-kappeB-inducing 
                 PN 
                 MAPK8 
               
               
                   
                 kinase 
               
               
                   
                 NFKBIA 
                 PN 
                 RELA 
               
               
                   
                 NFKBIA 
                 PN 
                 SRC 
               
               
                   
                 NSFB 
                 PN 
                 AKT1 
               
               
                   
                 NGFB 
                 PN 
                 EGR1 
               
               
                   
                 NGFB 
                 PN 
                 IFNG 
               
               
                   
                 NGFB 
                 PN 
                 LIF 
               
               
                   
                 NGFB 
                 PN 
                 MAPK8 
               
               
                   
                 NGFB 
                 PN 
                 PLAUR 
               
               
                   
                 NGFB 
                 PN 
                 PPP1R13B 
               
               
                   
                 NGFB 
                 PN 
                 RAC1 
               
               
                   
                 NGFB 
                 PN 
                 TP53 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 26 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 NID 
                 PN 
                 NKP3 
               
               
                   
                 nitric oxide 
                 PN 
                 SRC 
               
               
                   
                 synthase 
               
               
                   
                 N DA receptor 
                 PN 
                 PARP1 
               
               
                   
                 NNK 
                 PN 
                 CγP2E1 
               
               
                   
                 NNK 
                 PN 
                 PTGS1 
               
               
                   
                 NO 
                 PN 
                 BCL2 
               
               
                   
                 NO 
                 PN 
                 BCL2L1 
               
               
                   
                 NO 
                 PN 
                 GCG 
               
               
                   
                 NO 
                 PN 
                 GNRH1 
               
               
                   
                 NO 
                 PN 
                 HRAS 
               
               
                   
                 NO 
                 PN 
                 IL10 
               
               
                   
                 NO 
                 PN 
                 SPP1 
               
               
                   
                 NO 
                 PN 
                 TP53 
               
               
                   
                 noradrenaline 
                 PN 
                 AVP 
               
               
                   
                 norapinephrine 
                 PN 
                 APP 
               
               
                   
                 NOS1 
                 PN 
                 PTGS2 
               
               
                   
                 NOS2A 
                 PN 
                 HNGB1 
               
               
                   
                 NOS2A 
                 PN 
                 IL1R1 
               
               
                   
                 NOS2A 
                 PN 
                 JUN 
               
               
                   
                 NOS2A 
                 PN 
                 NFNB1A 
               
               
                   
                 NOS2A 
                 PN 
                 TP53 
               
               
                   
                 NOS3 
                 PN 
                 SRC 
               
               
                   
                 NOTCH3 
                 PN 
                 VAPK1 
               
               
                   
                 NPY 
                 PN 
                 CRH 
               
               
                   
                 NROB1 
                 PN 
                 NR5A1 
               
               
                   
                 NR3C1 
                 PN 
                 BCL2L1 
               
               
                   
                 NR3C1 
                 PN 
                 HSPCA 
               
               
                   
                 NR3C1 
                 PN 
                 KY3 
               
               
                   
                 NR3C1 
                 PN 
                 NFKBIA 
               
               
                   
                 NR5A2 
                 PN 
                 NROB2 
               
               
                   
                 NRG1 
                 PN 
                 NAPK14 
               
               
                   
                 NTS 
                 PN 
                 DRD2 
               
               
                   
                 NTS 
                 PN 
                 SST 
               
               
                   
                 NUCB2 
                 PN 
                 PPARA 
               
               
                   
                 Nuclear factor NF 
                 PN 
                 AHR 
               
               
                   
                 kappa B 
               
               
                   
                 Nuclear factor NF 
                 PN 
                 CISH 
               
               
                   
                 kappa B 
               
               
                   
                 Nuclear factor NF 
                 PN 
                 EBP 
               
               
                   
                 kappa B 
               
               
                   
                 Nuclear factor NF 
                 PN 
                 EGR1 
               
               
                   
                 kappa B 
               
               
                   
                 Nuclear factor NF 
                 PN 
                 F3 
               
               
                   
                 kappa B 
               
               
                   
                 Nuclear factor NF 
                 PN 
                 FOS 
               
               
                   
                 kappa B 
               
               
                   
                 Nuclear factor NF 
                 PN 
                 HYOX1 
               
               
                   
                 kappa B 
               
               
                   
                 Nuclear factor NF 
                 PN 
                 IRF1 
               
               
                   
                 kappa B 
               
               
                   
                 Nuclear factor NF 
                 PN 
                 NYC 
               
               
                   
                 kappa B 
               
               
                   
                 Nuclear factor NF 
                 PN 
                 NOS2A 
               
               
                   
                 kappa B 
               
               
                   
                 Nuclear factor NF 
                 PN 
                 REL 
               
               
                   
                 kappa B 
               
               
                   
                 okadaic acid 
                 PN 
                 IL1R1 
               
               
                   
                 opioid receptor 
                 PN 
                 NAPK1 
               
               
                   
                 OSN 
                 PN 
                 CDKN1A 
               
               
                   
                 OSN 
                 PN 
                 STAT3 
               
               
                   
                 OXT 
                 PN 
                 POYC 
               
               
                   
                 oxygen 
                 PN 
                 BOL2L1 
               
               
                   
                 oxygen 
                 PN 
                 SELP 
               
               
                   
                 Oxysterols 
                 PN 
                 CAT 
               
               
                   
                 PAH 
                 PN 
                 CYP1A1 
               
               
                   
                 PAK2 
                 PN 
                 ABL1 
               
               
                   
                 PARP1 
                 PN 
                 CASP7 
               
               
                   
                 PARP1 
                 PN 
                 CDKN1A 
               
               
                   
                 PARP1 
                 PN 
                 NAPK1 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 27 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 pathway-specific 
                 PN 
                 JUN 
               
               
                   
                 SYAD protein 
               
               
                   
                 pathway-specific 
                 PN 
                 NAPK8 
               
               
                   
                 SYAD protein 
               
               
                   
                 pathway-specific 
                 PN 
                 SYAD2 
               
               
                   
                 SYAD protein 
               
               
                   
                 PAKR 
                 PN 
                 CASP8 
               
               
                   
                 PAKR 
                 PN 
                 YAPK1 
               
               
                   
                 PAKR 
                 PN 
                 RAF1 
               
               
                   
                 PAKR 
                 PN 
                 TNFRSF6 
               
               
                   
                 PAX6 
                 PN 
                 INS 
               
               
                   
                 PC4 
                 PN 
                 CDKN1B 
               
               
                   
                 PCNA 
                 PN 
                 CDKN1A 
               
               
                   
                 PDCD8 
                 PN 
                 DIABL0 
               
               
                   
                 PDE40 
                 PN 
                 NAPK1 
               
               
                   
                 PDGFA 
                 PN 
                 NAP2K1 
               
               
                   
                 PDGFRB 
                 PN 
                 PLCG1 
               
               
                   
                 pentagastrin 
                 PN 
                 CCK 
               
               
                   
                 peptide receptor, 
                 PN 
                 CXCL12 
               
               
                   
                 G-protein coupled 
               
               
                   
                 peptide receptor, 
                 PN 
                 CKCR3 
               
               
                   
                 G-protein coupled 
               
               
                   
                 peptide receptor, 
                 PN 
                 RAC1 
               
               
                   
                 G-protein coupled 
               
               
                   
                 PF4 
                 PN 
                 IL8 
               
               
                   
                 PGE1 
                 PN 
                 IL10 
               
               
                   
                 PGE1 
                 PN 
                 IL4 
               
               
                   
                 PGE1 
                 PN 
                 PRL 
               
               
                   
                 PGE2 
                 PN 
                 BNP2 
               
               
                   
                 PGE2 
                 PN 
                 GH1 
               
               
                   
                 PGE2 
                 PN 
                 IL1R1 
               
               
                   
                 PGE2 
                 PN 
                 NPPA 
               
               
                   
                 PGF 
                 PN 
                 BHOA 
               
               
                   
                 PGF2 alpha 
                 PN 
                 PRL 
               
               
                   
                 phenylephrine 
                 PN 
                 NPPA 
               
               
                   
                 phosphatidylcholine 
                 PN 
                 CCL21 
               
               
                   
                 phosphatidylcholine 
                 PN 
                 F2 
               
               
                   
                 Phosphatidylinositol 
                 PN 
                 F3 
               
               
                   
                 3-kinas 
               
               
                   
                 Phosphatidylinositol 
                 PN 
                 CTSB 
               
               
                   
                 3-kinase 
               
               
                   
                 Phosphatidylinositol 
                 PN 
                 EIF4E 
               
               
                   
                 3-kinase 
               
               
                   
                 Phosphatidylinositol 
                 PN 
                 EPHA3 
               
               
                   
                 3-kinase 
               
               
                   
                 Phosphatidylinositol 
                 PN 
                 HIF1A 
               
               
                   
                 3-kinase 
               
               
                   
                 Phosphatidylinositol 
                 PN 
                 YDK2 
               
               
                   
                 3-kinase 
               
               
                   
                 Phosphatidylinositol 
                 PN 
                 NEF2A 
               
               
                   
                 3-kinase 
               
               
                   
                 Phosphatidylinositol 
                 PN 
                 PIPN11 
               
               
                   
                 3-kinase 
               
               
                   
                 phosphoinositide 
                 PN 
                 GRP58 
               
               
                   
                 PI 
                 PN 
                 NSHB 
               
               
                   
                 PIK3CA 
                 PN 
                 AKT1 
               
               
                   
                 PIK3CA 
                 PN 
                 PPP1R13B 
               
               
                   
                 PIK3CG 
                 PN 
                 RAC1 
               
               
                   
                 PIK3R1 
                 PN 
                 Phosphatidylinositol 
               
               
                   
                   
                   
                 3-kinase 
               
               
                   
                 PIN1 
                 PN 
                 STAT5A 
               
               
                   
                 PKA 
                 PN 
                 AKT1 
               
               
                   
                 PKA 
                 PN 
                 HRAS 
               
               
                   
                 PKA 
                 PN 
                 HSFB1 
               
               
                   
                 PKA 
                 PN 
                 IGF1 
               
               
                   
                 PKA 
                 PN 
                 NFKB1A 
               
               
                   
                 PKC 
                 PN 
                 DUSP1 
               
               
                   
                 PKC 
                 PN 
                 EIF4EBP1 
               
               
                   
                 PKC 
                 PN 
                 NET 
               
               
                   
                 PKC 
                 PN 
                 NPPA 
               
               
                   
                 PKC 
                 PN 
                 RB1 
               
               
                   
                 PKC 
                 PN 
                 SELP 
               
               
                   
                 PKC 
                 PN 
                 SRC 
               
               
                   
                 PLA2G2D 
                 PN 
                 NAPK1 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 28 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 PLAT 
                 PN 
                 LPA 
               
               
                   
                 PLAT 
                 PN 
                 PLG 
               
               
                   
                 PLAT 
                 PN 
                 SERPINE1 
               
               
                   
                 platelet-derived 
                 PN 
                 ADCY2 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 ENP2 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 CAT 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 DUSP1 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 GJA1 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 KLK3 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 NAP3K11 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 NAPK3 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 NYC 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 NGFB 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 PPARG 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 PTGIS 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 PTPN11 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 RAC1 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 RAF1 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 TXN 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 EDN1 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 NPPA 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PN 
                 VEGF 
               
               
                   
                 growth factor 
               
               
                   
                 PLAU 
                 PN 
                 NYP3 
               
               
                   
                 PLAU 
                 PN 
                 PLAT 
               
               
                   
                 PLAU 
                 PN 
                 SRC 
               
               
                   
                 PLAUR 
                 PN 
                 SERPINE1 
               
               
                   
                 PLCG1 
                 PN 
                 GSN 
               
               
                   
                 PLCG1 
                 PN 
                 PRKCN 
               
               
                   
                 PLCG1 
                 PN 
                 profilin 
               
               
                   
                 PLG 
                 PN 
                 ELA2 
               
               
                   
                 PNA 
                 PN 
                 ADCY2 
               
               
                   
                 PNA 
                 PN 
                 ADN 
               
               
                   
                 PNA 
                 PN 
                 CCND1 
               
               
                   
                 PNA 
                 PN 
                 DTR 
               
               
                   
                 PNA 
                 PN 
                 OUSP1 
               
               
                   
                 PNA 
                 PN 
                 ESR1 
               
               
                   
                 PNA 
                 PN 
                 NAP3K1 
               
               
                   
                 PNA 
                 PN 
                 NAPK1 
               
               
                   
                 PNA 
                 PN 
                 NAPK3 
               
               
                   
                 PNA 
                 PN 
                 YYC 
               
               
                   
                 PNA 
                 PN 
                 NPPA 
               
               
                   
                 PNA 
                 PN 
                 PAK1 
               
               
                   
                 PNA 
                 PN 
                 RAF1 
               
               
                   
                 PNA 
                 PN 
                 SST 
               
               
                   
                 PHCH 
                 PN 
                 GNA0 
               
               
                   
                 PNL 
                 PN 
                 TP53 
               
               
                   
                 porin 
                 PN 
                 BCL2L1 
               
               
                   
                 PPARG 
                 PN 
                 EGF 
               
               
                   
                 PPARG 
                 PN 
                 IRF1 
               
               
                   
                 PPARG 
                 PN 
                 NAPK1 
               
               
                   
                 PPARG 
                 PN 
                 NAPK3 
               
               
                   
                 PPARG 
                 PN 
                 NAPK3 
               
               
                   
                 PPARG 
                 PN 
                 TGFB1 
               
               
                   
                 PRKCA 
                 PN 
                 TP53 
               
               
                   
                 PRKCE 
                 PN 
                 calcium 
               
               
                   
                 PRKCE 
                 PN 
                 nap kinase 
               
               
                   
                 PRKCE 
                 PN 
                 RPSGK 
               
               
                   
                 PRKCZ 
                 PN 
                 RPSGKB1 
               
               
                   
                 PRKDC 
                 PN 
                 TP53 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 29 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 PRL 
                 PN 
                 AKT1 
               
               
                   
                 PRL 
                 PN 
                 CESH 
               
               
                   
                 PRL 
                 PN 
                 IFKG 
               
               
                   
                 PRL 
                 PN 
                 IGF2 
               
               
                   
                 PRL 
                 PN 
                 JUN 
               
               
                   
                 PRL 
                 PN 
                 LIF 
               
               
                   
                 PRL 
                 PN 
                 NOS2A 
               
               
                   
                 PRL 
                 PN 
                 TNF 
               
               
                   
                 progesterone 
                 PN 
                 DUSP1 
               
               
                   
                 progesterone 
                 PN 
                 GNRH1 
               
               
                   
                 progesterone 
                 PN 
                 HYGCR 
               
               
                   
                 progesterone 
                 PN 
                 LEP 
               
               
                   
                 prostaglandin 
                 PN 
                 EGFR 
               
               
                   
                 prostaglandin 
                 PN 
                 POEC 
               
               
                   
                 prostaglandin 
                 PN 
                 PRL 
               
               
                   
                 prostaglandin- 
                 PN 
                 VIP 
               
               
                   
                 endoperox de synthase 
               
               
                   
                 protein C 
                 PN 
                 F2R 
               
               
                   
                 (activated) 
               
               
                   
                 protein phosphatase 
                 PN 
                 F2 
               
               
                   
                 protein phosphatase 
                 PN 
                 IL6 
               
               
                   
                 protein 
                 PN 
                 RAF1 
               
               
                   
                 phosphatase 1 
               
               
                   
                 protein 
                 PN 
                 RB1 
               
               
                   
                 phosphatase 1 
               
               
                   
                 protein 
                 PN 
                 SP1 
               
               
                   
                 phosphatase 2A 
               
               
                   
                 protein tyrosine 
                 PN 
                 BCL2L1 
               
               
                   
                 kinase 
               
               
                   
                 protein tyrosine 
                 PN 
                 BDK 
               
               
                   
                 kinase 
               
               
                   
                 protein tyrosine 
                 PN 
                 CBL 
               
               
                   
                 kinase 
               
               
                   
                 protein tyrosine 
                 PN 
                   RS1 
               
               
                   
                 kinase 
               
               
                   
                 protein tyrosine 
                 PN 
                 NPPA 
               
               
                   
                 kinase 
               
               
                   
                 protein tyrosine 
                 PN 
                 PTK28 
               
               
                   
                 kinase 
               
               
                   
                 protein tyrosine 
                 PN 
                 SOCS3 
               
               
                   
                 kinase 
               
               
                   
                 protein tyrosine 
                 PN 
                 NYC 
               
               
                   
                 kinase 
               
               
                   
                 protein tyrosine 
                 PN 
                 PXN 
               
               
                   
                 phosphatase 
               
               
                   
                 PSD 
                 PN 
                 RAC1 
               
               
                   
                 PSEN1 
                 PN 
                 APP 
               
               
                   
                 PSYD9 
                 PN 
                 Cyp2b20 
               
               
                   
                 PTEN 
                 PN 
                 FOX01A 
               
               
                   
                 PTEN 
                 PN 
                 oxygen 
               
               
                   
                 PTGDS 
                 PN 
                 PPARG 
               
               
                   
                 PTGER1 
                 PN 
                 IL1B 
               
               
                   
                 PTGIS 
                 PN 
                 IL10 
               
               
                   
                 PTGS1 
                 PN 
                 PTGS2 
               
               
                   
                 PTGS2 
                 PN 
                 IL4 
               
               
                   
                 PTGS2 
                 PN 
                 NFKBIA 
               
               
                   
                 PTGS2 
                 PN 
                 PPARA 
               
               
                   
                 PTGS2 
                 PN 
                 PTGIS 
               
               
                   
                 PTH 
                 PN 
                 IL18 
               
               
                   
                 PTHLH 
                 PN 
                 EGFR 
               
               
                   
                 PTHLH 
                 PN 
                 PTH 
               
               
                   
                 PTHR1 
                 PN 
                 IGF1 
               
               
                   
                 PTK2 
                 PN 
                 BCAR1 
               
               
                   
                 PTK2 
                 PN 
                 CASP3 
               
               
                   
                 PTK2 
                 PN 
                 CASP3 
               
               
                   
                 PTK2 
                 PN 
                 NAPK3 
               
               
                   
                 PTK2 
                 PN 
                 PTEN 
               
               
                   
                 PTK2 
                 PN 
                 PTPN11 
               
               
                   
                 PTK2 
                 PN 
                 PKH 
               
               
                   
                 PTK2B 
                 PN 
                 RHOA 
               
               
                   
                 PTP4A3 
                 PN 
                 JAK2 
               
               
                   
                 PTPRA 
                 PN 
                 SRC 
               
               
                   
                 PTPRC 
                 PN 
                 STAT6 
               
               
                   
                 PTTGI 
                 PN 
                 TP53 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 30 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 quinone 
                 PN 
                 TP53 
               
               
                   
                 RA 
                 PN 
                 CYP1A1 
               
               
                   
                 RAC1 
                 PN 
                 COH1 
               
               
                   
                 RAC1 
                 PN 
                 map kinase 
               
               
                   
                 RAC1 
                 PN 
                 VAP3K1 
               
               
                   
                 RAC1 
                 PN 
                 NAPK14 
               
               
                   
                 RAC1 
                 PN 
                 NNP2 
               
               
                   
                 RAC1 
                 PN 
                 RHOA 
               
               
                   
                 RAC1 
                 PN 
                 SAP kinase 
               
               
                   
                 RAF1 
                 PN 
                 BRAF 
               
               
                   
                 RAF1 
                 PN 
                 RPSGKB1 
               
               
                   
                 RALGDS 
                 PN 
                 STAT3 
               
               
                   
                 RAPGEF1 
                 PN 
                 RAF1 
               
               
                   
                 RARA 
                 PN 
                 IGFBP3 
               
               
                   
                 RAS small monomeric 
                 PN 
                 CCHD1 
               
               
                   
                 GTPase 
               
               
                   
                 RAS small monomeric 
                 PN 
                 CDKN2A 
               
               
                   
                 GTPase 
               
               
                   
                 RAS small monomeric 
                 PN 
                 E2F1 
               
               
                   
                 GTPase 
               
               
                   
                 RAS small monomeric 
                 PN 
                 VAP2K6 
               
               
                   
                 GTPase 
               
               
                   
                 RAS small monomeric 
                 PN 
                 VAPK14 
               
               
                   
                 GTPase 
               
               
                   
                 RAS small monomeric 
                 PN 
                 PAK1 
               
               
                   
                 GTPase 
               
               
                   
                 RAS small monomeric 
                 PN 
                 PPPIR13B 
               
               
                   
                 GTPase 
               
               
                   
                 RAS small monomeric 
                 PN 
                 TRAF3 
               
               
                   
                 GTPase 
               
               
                   
                 RASA1 
                 PN 
                 GRLF1 
               
               
                   
                 RASD1 
                 PN 
                 NAPK3 
               
               
                   
                 RB1 
                 PN 
                 CDKN1A 
               
               
                   
                 RB1 
                 PN 
                 COKN1B 
               
               
                   
                 RB1 
                 PN 
                 SP1 
               
               
                   
                 RB1 
                 PN 
                 TGFB2 
               
               
                   
                 RBL1 
                 PN 
                 CCND1 
               
               
                   
                 RBL1 
                 PN 
                 CDKN1A 
               
               
                   
                 RBL2 
                 PN 
                 CCNE1 
               
               
                   
                 receptor signaling 
                 PN 
                 AKT1 
               
               
                   
                 protein 
               
               
                   
                 receptor tyrosine 
                 PN 
                 PTPN6 
               
               
                   
                 kinase 
               
               
                   
                 REL 
                 PN 
                 BCL2L1 
               
               
                   
                 REL 
                 PN 
                 RELB 
               
               
                   
                 RELA 
                 PN 
                 EP300 
               
               
                   
                 RELB 
                 PN 
                 NFKBIA 
               
               
                   
                 REH 
                 PN 
                 ARG2 
               
               
                   
                 REN 
                 PN 
                 NPY 
               
               
                   
                 RET 
                 PN 
                 AKT1 
               
               
                   
                 RETN 
                 PN 
                 AKT1 
               
               
                   
                 RETN 
                 PN 
                 EDN1 
               
               
                   
                 RGS2 
                 PN 
                 IL2 
               
               
                   
                 RHO 
                 PN 
                 JUN 
               
               
                   
                 RHO 
                 PN 
                 GRK1 
               
               
                   
                 Rho small monomeric 
                 PN 
                 CDCA2 
               
               
                   
                 GTPase 
               
               
                   
                 Rho small monomeric 
                 PN 
                 NAPK8 
               
               
                   
                 GTPase 
               
               
                   
                 Rho small monomeric 
                 PN 
                 PTK2 
               
               
                   
                 GTPase 
               
               
                   
                 Rho small monomeric 
                 PN 
                 RAC1 
               
               
                   
                 GTPase 
               
               
                   
                 Rho small monomeric 
                 PN 
                 RHOA 
               
               
                   
                 GTPase 
               
               
                   
                 RHOA 
                 PN 
                 geranylgeranyl 
               
               
                   
                   
                   
                 pyrophosphate 
               
               
                   
                 RHOA 
                 PN 
                 map kinase 
               
               
                   
                 RHOA 
                 PN 
                 NAPK1 
               
               
                   
                 RHOA 
                 PN 
                 NKL1 
               
               
                   
                 RHOA 
                 PN 
                 NYOD1 
               
               
                   
                 RHOA 
                 PN 
                 oxygen 
               
               
                   
                 RHOA 
                 PN 
                 PAKG 
               
               
                   
                 RHOA 
                 PN 
                 PCLD 
               
               
                   
                 RHOA 
                 PN 
                 RAF1 
               
               
                   
                 RHOA 
                 PN 
                 TNC 
               
               
                   
                 RIPK1 
                 PN 
                 MAP3K1 
               
               
                   
                 RIPK2 
                 PN 
                 MAPK1 
               
               
                   
                 RIPK2 
                 PN 
                 MAPK3 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 31 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 RPS6K 
                 PN 
                 CALCA 
               
               
                   
                 RPS6K 
                 PN 
                 CREB1 
               
               
                   
                 RPS6K 
                 PN 
                 DUSP1 
               
               
                   
                 RPS6K 
                 PN 
                 EIF4E 
               
               
                   
                 RPS6K 
                 PN 
                 HSPA4 
               
               
                   
                 RPS6K 
                 PN 
                 SELL 
               
               
                   
                 RPS6K 
                 PN 
                 TERF21P 
               
               
                   
                 RPS6K 
                 PN 
                 TH 
               
               
                   
                 RPS6K81 
                 PN 
                 MAPKS 
               
               
                   
                 RRAS 
                 PN 
                 HRAS 
               
               
                   
                 RRAS 
                 PN 
                 PTK2 
               
               
                   
                 RRAS 
                 PN 
                 RAF1 
               
               
                   
                 RUNX2 
                 PN 
                 TNFSF11 
               
               
                   
                 SI00B 
                 PN 
                 IFN6 
               
               
                   
                 SIP 
                 PN 
                 RAC1 
               
               
                   
                 SAP kinase 
                 PN 
                 BCL2 
               
               
                   
                 SAP kinase 
                 PN 
                 DUSP1 
               
               
                   
                 SAP kinase 
                 PN 
                 IL6 
               
               
                   
                 SAP kinase 
                 PN 
                 IL8 
               
               
                   
                 SCARB1 
                 PN 
                 CAV1 
               
               
                   
                 SCLY 
                 PN 
                 CSF2 
               
               
                   
                 SCT 
                 PN 
                 INS 
               
               
                   
                 SELE 
                 PN 
                 STAT6 
               
               
                   
                 SELL 
                 PN 
                 MAPK8 
               
               
                   
                 SELPLG 
                 PN 
                 PKC 
               
               
                   
                 SERPINE1 
                 PN 
                 MAPK3 
               
               
                   
                 SERPINE2 
                 PN 
                 F2R 
               
               
                   
                 SHC1 
                 PN 
                 MAPK3 
               
               
                   
                 SHC1 
                 PN 
                 PTEN 
               
               
                   
                 SHH 
                 PN 
                 BHP2 
               
               
                   
                 SLC12A9 
                 PN 
                 RB1 
               
               
                   
                 SLC2A4 
                 PN 
                 SLC2A1 
               
               
                   
                 SLJT2 
                 PN 
                 CXCL12 
               
               
                   
                 SMAD1 
                 PN 
                 SMAD4 
               
               
                   
                 SMAD3 
                 PN 
                 ESR1 
               
               
                   
                 SMAD3 
                 PN 
                 JUN 
               
               
                   
                 SMAD3 
                 PN 
                 MAP3K1 
               
               
                   
                 SMAD3 
                 PN 
                 NR3C1 
               
               
                   
                 SMAD3 
                 PN 
                 SMAD7 
               
               
                   
                 SMAD3 
                 PN 
                 MDR 
               
               
                   
                 SKAD4 
                 PN 
                 MAPK3 
               
               
                   
                 SMAD5 
                 PN 
                 SMAD9 
               
               
                   
                 small numeric 
                 PN 
                 RAF1 
               
               
                   
                 GTPase 
               
               
                   
                 SMAP 
                 PN 
                 MAPK1 
               
               
                   
                 SOD2 
                 PN 
                 PGE2 
               
               
                   
                 SP1 
                 PN 
                 CC2D1 
               
               
                   
                 SP1 
                 PN 
                 ILIF8 
               
               
                   
                 SP1 
                 PN 
                 IRF1 
               
               
                   
                 SP1 
                 PN 
                 MUC2 
               
               
                   
                 SP1 
                 PN 
                 THFRSF6 
               
               
                   
                 SP1 
                 PN 
                 TP53 
               
               
                   
                 sphingosine-1- 
                 PN 
                 TGF81 
               
               
                   
                 phosohate phosphatase 
               
               
                   
                 SPN 
                 PN 
                 TNF 
               
               
                   
                 SPP1 
                 PN 
                 MAPK1 
               
               
                   
                 SRC 
                 PN 
                 ADRBK1 
               
               
                   
                 SRC 
                 PN 
                 ATF2 
               
               
                   
                 SRC 
                 PN 
                 CAV1 
               
               
                   
                 SRC 
                 PN 
                 CCL21 
               
               
                   
                 SRC 
                 PN 
                 GRB2 
               
               
                   
                 SRC 
                 PN 
                 HRAS 
               
               
                   
                 SRC 
                 PN 
                 MAP2K2 
               
               
                   
                 SRC 
                 PN 
                 NYP2 
               
               
                   
                 SRC 
                 PN 
                 NYP9 
               
               
                   
                 SRC 
                 PN 
                 PLAUR 
               
               
                   
                 src family 
                 PN 
                 GAV1 
               
               
                   
                 src family 
                 PN 
                 CBL 
               
               
                   
                 src family 
                 PN 
                 HRAS 
               
               
                   
                 src family 
                 PN 
                 LYN 
               
               
                   
                 src family 
                 PN 
                 MAPK9 
               
               
                   
                 src family 
                 PN 
                 PLAUR 
               
               
                   
                 SREBF1 
                 PN 
                 HYGCR 
               
               
                   
                 SREBF1 
                 PN 
                 LDLR 
               
               
                   
                 SREBF1 
                 PN 
                 LEP 
               
               
                   
                 SRF 
                 PN 
                 IER2 
               
               
                   
                 SST 
                 PN 
                 CDC25C 
               
               
                   
                 SST 
                 PN 
                 IL2 
               
               
                   
                 SSTR2 
                 PN 
                 PTPN11 
               
               
                   
                 SSTR2 
                 PN 
                 PTPN6 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 32 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 STAT3 
                 PN 
                 CISH 
               
               
                   
                 STAT3 
                 PN 
                 JUN 
               
               
                   
                 STAT3 
                 PN 
                 SOCS3 
               
               
                   
                 STAT5A 
                 PN 
                 ESR1 
               
               
                   
                 STAT5B 
                 PN 
                 SOCS3 
               
               
                   
                 STAT6 
                 PN 
                 IFN6 
               
               
                   
                 steroid receptor 
                 PN 
                 PGR 
               
               
                   
                 STNN1 
                 PN 
                 TP53 
               
               
                   
                 STX4A 
                 PN 
                 F2 
               
               
                   
                 superoxide cisutase 
                 PN 
                 INS 
               
               
                   
                 SYK 
                 PN 
                 MPK3 
               
               
                   
                 T-cell transcription 
                 PN 
                 GSK3B 
               
               
                   
                 factor NFATC 
               
               
                   
                 T-cell transcription 
                 PN 
                 MAPK8 
               
               
                   
                 factor NFATC 
               
               
                   
                 TBP 
                 PN 
                 TP53 
               
               
                   
                 TCE 
                 PN 
                 CYP1A1 
               
               
                   
                 TCE 
                 PN 
                 CYP2E1 
               
               
                   
                 TCE 
                 PN 
                 Cyp3a11 
               
               
                   
                 T-cell receptor 
                 PN 
                 CBLB 
               
               
                   
                 T3 complex 
               
               
                   
                 T-cell receptor 
                 PN 
                 JUN 
               
               
                   
                 T3 complex 
               
               
                   
                 T-cell receptor 
                 PN 
                 MAP2K1 
               
               
                   
                 T3 complex 
               
               
                   
                 T-cell receptor 
                 PN 
                 MAP3K1 
               
               
                   
                 T3 complex 
               
               
                   
                 T-cell receptor 
                 PN 
                 RAC1 
               
               
                   
                 T3 complex 
               
               
                   
                 TCF1 
                 PN 
                 ALB 
               
               
                   
                 TDE1 
                 PN 
                 CASP9 
               
               
                   
                 telomerase 
                 PN 
                 MAPK1 
               
               
                   
                 testosterone 
                 PN 
                 CYP19A1 
               
               
                   
                 testosterone 
                 PN 
                 TAC1 
               
               
                   
                 testosterone 
                 PN 
                 TGFB1 
               
               
                   
                 TFDP1 
                 PN 
                 E2F1 
               
               
                   
                 TFF3 
                 PN 
                 MAPK1 
               
               
                   
                 TFRC 
                 PN 
                 TF 
               
               
                   
                 TG 
                 PN 
                 IL1B 
               
               
                   
                 TGFB1 
                 PN 
                 activin 
               
               
                   
                 TGFB1 
                 PN 
                 BGN 
               
               
                   
                 TGFB1 
                 PN 
                 COL21 
               
               
                   
                 TGFB1 
                 PN 
                 CTF1 
               
               
                   
                 TGFB1 
                 PN 
                 DPT 
               
               
                   
                 TGFB1 
                 PN 
                 FST 
               
               
                   
                 TGFB1 
                 PN 
                 HYAL2 
               
               
                   
                 TGFB1 
                 PN 
                 IGFBP2 
               
               
                   
                 TGFB1 
                 PN 
                 IGFBP5 
               
               
                   
                 TGFB1 
                 PN 
                 IL7 
               
               
                   
                 TGFB1 
                 PN 
                 inhibitory SMAD protein 
               
               
                   
                 TGFB1 
                 PN 
                 KLRC1 
               
               
                   
                 TGFB1 
                 PN 
                 LAMA1 
               
               
                   
                 TGFB1 
                 PN 
                 LOK 
               
               
                   
                 TGFB1 
                 PN 
                 LPA sodium sell 
               
               
                   
                 TGFB1 
                 PN 
                 MAP2K4 
               
               
                   
                 TGFB1 
                 PN 
                 NF1 
               
               
                   
                 TGFB1 
                 PN 
                 NPPB 
               
               
                   
                 TGFB1 
                 PN 
                 PGE1 
               
               
                   
                 TGFB1 
                 PN 
                 PLAS4 
               
               
                   
                 TGFB1 
                 PN 
                 PKG 
               
               
                   
                 TGFB1 
                 PN 
                 PLA2G1B 
               
               
                   
                 TGFB1 
                 PN 
                 PLAUR 
               
               
                   
                 TGFB1 
                 PN 
                 PPARA 
               
               
                   
                 TGFB1 
                 PN 
                 procollagen 
               
               
                   
                   
                   
                 N-endopeptidase 
               
               
                   
                 TGFB1 
                 PN 
                 RA 
               
               
                   
                 TGFB1 
                 PN 
                 RAC1 
               
               
                   
                 TGFB1 
                 PN 
                 REL 
               
               
                   
                 TGFB1 
                 PN 
                 SERPINE1 
               
               
                   
                 TGFB1 
                 PN 
                 SHADG 
               
               
                   
                 TGFB1 
                 PN 
                 SMAD7 
               
               
                   
                 TGFB1 
                 PN 
                 THBS2 
               
               
                   
                 TGFBR1 
                 PN 
                 SMAD3 
               
               
                   
                 THBD 
                 PN 
                 PROC 
               
               
                   
                 THBS1 
                 PN 
                 MNP2 
               
               
                   
                 THP0 
                 PN 
                 STAT1 
               
               
                   
                 THP0 
                 PN 
                 STAT3 
               
               
                   
                 THP0 
                 PN 
                 TNF 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 33 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 thrombin 
                 PN 
                 DTR 
               
               
                   
                 thrombin 
                 PN 
                 EGFR 
               
               
                   
                 thrombin 
                 PN 
                 FN1 
               
               
                   
                 thrombin 
                 PN 
                 PRKOD 
               
               
                   
                 thrombin 
                 PN 
                 PRKCE 
               
               
                   
                 thrombin 
                 PN 
                 PTGTS 
               
               
                   
                 thrombin 
                 PN 
                 PTK2 
               
               
                   
                 thrombin 
                 PN 
                 SERPINE1 
               
               
                   
                 thyroid stimulating 
                 PN 
                 STAT3 
               
               
                   
                 hormone 
               
               
                   
                 TIKP1 
                 PN 
                 MAPK14 
               
               
                   
                 TLR4 
                 PN 
                 IL10 
               
               
                   
                 TLR4 
                 PN 
                 IL6 
               
               
                   
                 TLR4 
                 PN 
                 TNF 
               
               
                   
                 TNA 
                 PN 
                 PLG 
               
               
                   
                 TNC 
                 PN 
                 HYP13 
               
               
                   
                 TNF 
                 PN 
                 ADH 
               
               
                   
                 TNF 
                 PN 
                 ANXA1 
               
               
                   
                 TNF 
                 PN 
                 ATF3 
               
               
                   
                 TNF 
                 PN 
                 BCL2A1 
               
               
                   
                 TNF 
                 PN 
                 BCL2L1 
               
               
                   
                 TNF 
                 PN 
                 BCL3 
               
               
                   
                 TNF 
                 PN 
                 CD4 
               
               
                   
                 TNF 
                 PN 
                 CD80 
               
               
                   
                 TNF 
                 PN 
                 CD8A 
               
               
                   
                 TNF 
                 PN 
                 CHUX 
               
               
                   
                 TNF 
                 PN 
                 CTNNB1 
               
               
                   
                 TNF 
                 PN 
                 CXCL9 
               
               
                   
                 TNF 
                 PN 
                 DUSP1 
               
               
                   
                 TNF 
                 PN 
                 E2 
               
               
                   
                 TNF 
                 PN 
                 E2F1 
               
               
                   
                 TNF 
                 PN 
                 exo-alpha-sialidase 
               
               
                   
                 TNF 
                 PN 
                 ferritin 
               
               
                   
                 TNF 
                 PN 
                 FGF2 
               
               
                   
                 TNF 
                 PN 
                 HDL 
               
               
                   
                 TNF 
                 PN 
                 HIF1A 
               
               
                   
                 TNF 
                 PN 
                 HRAS 
               
               
                   
                 TNF 
                 PN 
                 IFNB1 
               
               
                   
                 TNF 
                 PN 
                 Ikappa B 
               
               
                   
                 TNF 
                 PN 
                 ILIORA 
               
               
                   
                 TNF 
                 PN 
                 IL11 
               
               
                   
                 TNF 
                 PN 
                 IL9 
               
               
                   
                 TNF 
                 PN 
                 IRF1 
               
               
                   
                 TNF 
                 PN 
                 ITGA4 
               
               
                   
                 TNF 
                 PN 
                 LEF 
               
               
                   
                 TNF 
                 PN 
                 LFA-1 (integrin) 
               
               
                   
                 TNF 
                 PN 
                 MAP2K1 
               
               
                   
                 TNF 
                 PN 
                 MAP2K2 
               
               
                   
                 TNF 
                 PN 
                 MAP2K4 
               
               
                   
                 TNF 
                 PN 
                 MAP3K1 
               
               
                   
                 TNF 
                 PN 
                 MAP3K5 
               
               
                   
                 TNF 
                 PN 
                 MAP3K3 
               
               
                   
                 TNF 
                 PN 
                 HSK1 
               
               
                   
                 TNF 
                 PN 
                 ND 
               
               
                   
                 TNF 
                 PN 
                 NR3C1 
               
               
                   
                 TNF 
                 PN 
                 PDGFA 
               
               
                   
                 TNF 
                 PN 
                 P13 
               
               
                   
                 TNF 
                 PN 
                 PPARA 
               
               
                   
                 TNF 
                 PN 
                 PRKCI 
               
               
                   
                 TNF 
                 PN 
                 protein tyrosine kinase 
               
               
                   
                   
                   
                 inhibitor 
               
               
                   
                 TNF 
                 PN 
                 PTGS2 
               
               
                   
                 TNF 
                 PN 
                 RAC1 
               
               
                   
                 TNF 
                 PN 
                 RHOA 
               
               
                   
                 TNF 
                 PN 
                 SAP kinase 
               
               
                   
                 TNF 
                 PN 
                 SERPING1 
               
               
                   
                 TNF 
                 PN 
                 SHAD1 
               
               
                   
                 TNF 
                 PN 
                 SOCS1 
               
               
                   
                 TNF 
                 PN 
                 SOD1 
               
               
                   
                 TNF 
                 PN 
                 SOD2 
               
               
                   
                 TNF 
                 PN 
                 SPHK1 
               
               
                   
                 TNF 
                 PN 
                 STAT1 
               
               
                   
                 TNF 
                 PN 
                 STAT6 
               
               
                   
                 TNF 
                 PN 
                 superoxide dismutase 
               
               
                   
                 TNF 
                 PN 
                 TLR2 
               
               
                   
                 TNF 
                 PN 
                 TNFRSF1A 
               
               
                   
                 TNF 
                 PN 
                 TRAD0 
               
               
                   
                 TNF 
                 PN 
                 TRAF1 
               
               
                   
                 TNF 
                 PN 
                 TRAF4 
               
               
                   
                 TNF 
                 PN 
                 TXN 
               
               
                   
                 TNF 
                 PN 
                 VIP 
               
               
                   
                 TNF 
                 PN 
                 ZFP36 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 34 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 TNFATPB 
                 PN 
                 NFKBIA 
               
               
                   
                 TNF-alpha receptor 
                 PN 
                 NFKBIA 
               
               
                   
                 TNFRSF108 
                 PN 
                 CASP10 
               
               
                   
                 TNFRSF1A 
                 PN 
                 CASP3 
               
               
                   
                 TNFRSF1A 
                 PN 
                 VAPK14 
               
               
                   
                 TNFRSF5 
                 PN 
                 CD86 
               
               
                   
                 TNFRSF5 
                 PN 
                 STAT6 
               
               
                   
                 TNFRSF6 
                 PN 
                 OOKNIA 
               
               
                   
                 TNFRSF6 
                 PN 
                 IL10 
               
               
                   
                 TNFRSF6 
                 PN 
                 IL3 
               
               
                   
                 TNFRSF6 
                 PN 
                 NAPK14 
               
               
                   
                 TNFRSF6 
                 PN 
                 BAPK9 
               
               
                   
                 TNFRSF6 
                 PN 
                 NFKB1 
               
               
                   
                 TNFRSF6 
                 PN 
                 PPARA 
               
               
                   
                 TNFRSF6 
                 PN 
                 RAC1 
               
               
                   
                 TNFRSF10 
                 PN 
                 BCL2 
               
               
                   
                 TNFRSF10 
                 PN 
                 BCL2L1 
               
               
                   
                 TNFRSF10 
                 PN 
                 CYCS 
               
               
                   
                 TNFRSF10 
                 PN 
                 EGF 
               
               
                   
                 TNFRSF10 
                 PN 
                 NAPK1 
               
               
                   
                 TNFRSF10 
                 PN 
                 NFKBIA 
               
               
                   
                 TNFRSF10 
                 PN 
                 PARP1 
               
               
                   
                 TNFRSF10 
                 PN 
                 TKF 
               
               
                   
                 TNFRSF11 
                 PN 
                 HFKBIA 
               
               
                   
                 TNFRSF4 
                 PN 
                 IL4 
               
               
                   
                 TNFRSF5 
                 PN 
                 IL10 
               
               
                   
                 TNFRSF5 
                 PN 
                 NAPK1 
               
               
                   
                 TNFRSF5 
                 PN 
                 TNFSF11 
               
               
                   
                 TNFRSF6 
                 PN 
                 NFK61 
               
               
                   
                 Toll receptor 
                 PN 
                 BCL2 
               
               
                   
                 TP53 
                 PN 
                 CASP2 
               
               
                   
                 TP53 
                 PN 
                 CASP8 
               
               
                   
                 TP53 
                 PN 
                 ESR1 
               
               
                   
                 TP53 
                 PN 
                 HAPK1 
               
               
                   
                 TP53 
                 PN 
                 HDN2 
               
               
                   
                 TP53 
                 PN 
                 NET 
               
               
                   
                 TP53 
                 PN 
                 PEG3 
               
               
                   
                 TP53 
                 PN 
                 PPH1D 
               
               
                   
                 TP53 
                 PN 
                 PYCR1 
               
               
                   
                 TP53 
                 PN 
                 SFH 
               
               
                   
                 TP53 
                 PN 
                 MT1 
               
               
                   
                 TP73 
                 PN 
                 CC G1 
               
               
                   
                 TP73 
                 PN 
                 EDX2 
               
               
                   
                 TRAF2 
                 PN 
                 GCXR 
               
               
                   
                 TRAF2 
                 PN 
                 HAP3K1 
               
               
                   
                 TRAF2 
                 PN 
                 TNFRSF1A 
               
               
                   
                 TRAF3 
                 PN 
                 KFIBIA 
               
               
                   
                 TRAF3 
                 PN 
                 TNFRSF5 
               
               
                   
                 TRAF6 
                 PN 
                 NAPK14 
               
               
                   
                 TRAF6 
                 PN 
                 TRAF3 
               
               
                   
                 transcription 
                 PN 
                 BOL2L11 
               
               
                   
                 factor 
               
               
                   
                 transcription 
                 PN 
                 PONG 
               
               
                   
                 factor 
                 PN 
               
               
                   
                 transcription 
                 PN 
                 PPARG 
               
               
                   
                 factor 
                 PN 
               
               
                   
                 transforming 
                 PN 
                 COKN1A 
               
               
                   
                 growth factor 
                 PN 
               
               
                   
                 TSG1 
                 PN 
                 TSC2 
               
               
                   
                 TTF1 
                 PN 
                 TG 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 35 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 tumor necrosis 
                 PN 
                 BCL2L1 
               
               
                   
                 factor 
               
               
                   
                 tumor necrosis 
                 PN 
                 HGF 
               
               
                   
                 factor 
               
               
                   
                 tumor necrosis 
                 PN 
                   OX1 
               
               
                   
                 factor 
               
               
                   
                 tumor necrosis 
                 PN 
                 IRS1 
               
               
                   
                 factor 
               
               
                   
                 tumor necrosis 
                 PN 
                 LIF 
               
               
                   
                 factor 
               
               
                   
                 tumor necrosis 
                 PN 
                 NOS2A 
               
               
                   
                 factor 
               
               
                   
                 tumor necrosis 
                 PN 
                 PONC 
               
               
                   
                 factor 
               
               
                   
                 tumor necrosis 
                 PN 
                 PTGS2 
               
               
                   
                 factor 
               
               
                   
                 tumor necrosis 
                 PN 
                 REL 
               
               
                   
                 factor 
               
               
                   
                 tumor necrosis 
                 PN 
                 S0D2 
               
               
                   
                 factor 
               
               
                   
                 tumor necrosis 
                 PN 
                 SST 
               
               
                   
                 factor 
               
               
                   
                 tumor necrosis 
                 PN 
                 STAT6 
               
               
                   
                 factor 
               
               
                   
                 tumor necrosis 
                 PN 
                 VCAK1 
               
               
                   
                 factor 
               
               
                   
                 tumor necrosis 
                 PN 
                 IL13 
               
               
                   
                 factor 
               
               
                   
                 UBL3 
                 PN 
                 TGFB1 
               
               
                   
                 yesopressin 
                 PN 
                 AVP 
               
               
                   
                 VAV1 
                 PN 
                 CBL 
               
               
                   
                 VAV1 
                 PN 
                 CDC42 
               
               
                   
                 VAV1 
                 PN 
                 PAK1 
               
               
                   
                 VAV1 
                 PN 
                 RAC1 
               
               
                   
                 VAV2 
                 PN 
                 CDC42 
               
               
                   
                 VAV2 
                 PN 
                 RAC1 
               
               
                   
                 VAV3 
                 PN 
                 STAT3 
               
               
                   
                 VCAN1 
                 PN 
                 PTK2 
               
               
                   
                 VCAN1 
                 PN 
                 RAC1 
               
               
                   
                 VDR 
                 PN 
                 TTGAN 
               
               
                   
                 VEGF 
                 PN 
                 FLT1 
               
               
                   
                 VEGF 
                 PN 
                 LCP1 
               
               
                   
                 VEGF 
                 PN 
                 PTK2 
               
               
                   
                 VEGF 
                 PN 
                 PTK2B 
               
               
                   
                 VEGF 
                 PN 
                 RAC1 
               
               
                   
                 VEGF 
                 PN 
                 SELE 
               
               
                   
                 VIP 
                 PN 
                 GALGA 
               
               
                   
                 VIP 
                 PN 
                 GCG 
               
               
                   
                 VIP 
                 PN 
                 SST 
               
               
                   
                 VLDL 
                 PN 
                 LEP 
               
               
                   
                 voltage-dependent 
                 PN 
                 GN   
               
               
                   
                 calcium channel 
               
               
                   
                 VTN 
                 PN 
                 FN1 
               
               
                   
                 VTN 
                 PN 
                 SERPINE1 
               
               
                   
                 water 
                 PN 
                 NPPA 
               
               
                   
                   T1 
                 PN 
                 NRDB1 
               
               
                   
                 ZAP70 
                 PN 
                 PTPK6 
               
               
                   
                 ZAP148 
                 PN 
                 TP53 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 36 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 A2Y 
                 PP 
                 TGFB1 
               
               
                   
                 ABL1 
                 PP 
                 H2O2 
               
               
                   
                 ABL1 
                 PP 
                 HCK 
               
               
                   
                 ABL1 
                 PP 
                 integrin 
               
               
                   
                 ABL1 
                 PP 
                 HCK1 
               
               
                   
                 ABL1 
                 PP 
                 PRKCD 
               
               
                   
                 ABL1 
                 PP 
                 src family 
               
               
                   
                 ABL1 
                 PP 
                 TP73 
               
               
                   
                 ACDC 
                 PP 
                 INS 
               
               
                   
                 acetyltransferase 
                 PP 
                 INS 
               
               
                   
                 ADAKTSL1 
                 PP 
                 TGFB1 
               
               
                   
                 ADCY2 
                 PP 
                 FOS 
               
               
                   
                 ADCY2 
                 PP 
                 MAPK3 
               
               
                   
                 ADCY2 
                 PP 
                 PONC 
               
               
                   
                 ADCYAP1 
                 PP 
                 ADCY2 
               
               
                   
                 ADCYAP1 
                 PP 
                 TAC1 
               
               
                   
                 ADORA2A 
                 PP 
                 MAPKS 
               
               
                   
                 ADP 
                 PP 
                 JUN 
               
               
                   
                 ADP 
                 PP 
                 MAPK8 
               
               
                   
                 ADP 
                 PP 
                 P2RY1 
               
               
                   
                 ADRBK1 
                 PP 
                 RAS small monomeric 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                 AGT 
                 PP 
                 EDN1 
               
               
                   
                 AGT 
                 PP 
                 EGF 
               
               
                   
                 AGT 
                 PP 
                 HRAS 
               
               
                   
                 AGT 
                 PP 
                 MAPK3 
               
               
                   
                 AGT 
                 PP 
                 Phosphatidylinositol 
               
               
                   
                   
                   
                 3-kinase 
               
               
                   
                 AGT 
                 PP 
                 PLCG1 
               
               
                   
                 AGT 
                 PP 
                 TKF 
               
               
                   
                 AGT 
                 PP 
                 VEGF 
               
               
                   
                 AGTR1 
                 PP 
                 ANG 
               
               
                   
                 AGTR1 
                 PP 
                 IGF1 
               
               
                   
                 AGTR1 
                 PP 
                 SERPINE1 
               
               
                   
                 AKR1B1 
                 PP 
                 TNF 
               
               
                   
                 AKT1 
                 PP 
                 ADP 
               
               
                   
                 AKT1 
                 PP 
                 calcium-dependent cell 
               
               
                   
                   
                   
                 adhesion molecule 
               
               
                   
                 AKT1 
                 PP 
                 catenin 
               
               
                   
                 AKT1 
                 PP 
                 CDC37 
               
               
                   
                 AKT1 
                 PP 
                 CDKN1A 
               
               
                   
                 AKT1 
                 PP 
                 CREB1 
               
               
                   
                 AKT1 
                 PP 
                 CSF1 
               
               
                   
                 AKT1 
                 PP 
                 CSF2 
               
               
                   
                 AKT1 
                 PP 
                 CTGF 
               
               
                   
                 AKT1 
                 PP 
                 EGF 
               
               
                   
                 AKT1 
                 PP 
                 estrogen 
               
               
                   
                 AKT1 
                 PP 
                 F2 
               
               
                   
                 AKT1 
                 PP 
                 GSK3A 
               
               
                   
                 AKT1 
                 PP 
                 HGF 
               
               
                   
                 AKT1 
                 PP 
                 IFNG 
               
               
                   
                 AKT1 
                 PP 
                 IGF1R 
               
               
                   
                 AKT1 
                 PP 
                 IgG 
               
               
                   
                 AKT1 
                 PP 
                 IL5 
               
               
                   
                 AKT1 
                 PP 
                 IL8RB 
               
               
                   
                 AKT1 
                 PP 
                   LK 
               
               
                   
                 AKT1 
                 PP 
                   RS 
               
               
                   
                 AKT1 
                 PP 
                 insulins 
               
               
                   
                 AKT1 
                 PP 
                 integrin 
               
               
                   
                 AKT1 
                 PP 
                 JAK2 
               
               
                   
                 AKT1 
                 PP 
                 laminio 
               
               
                   
                 AKT1 
                 PP 
                 LEP 
               
               
                   
                 AKT1 
                 PP 
                 lipid 
               
               
                   
                 AKT1 
                 PP 
                 MSK1 
               
               
                   
                 AKT1 
                 PP 
                 MYOD1 
               
               
                   
                 AKT1 
                 PP 
                 NPPA 
               
               
                   
                 AKT1 
                 PP 
                 Nuclear factor NF 
               
               
                   
                   
                   
                 kappa B 
               
               
                   
                 AKT1 
                 PP 
                 OR2C1 
               
               
                   
                 AKT1 
                 PP 
                 PAK1 
               
               
                   
                 AKT1 
                 PP 
                 peptide receptor, 
               
               
                   
                   
                   
                 G-protein coupled 
               
               
                   
                 AKT1 
                 PP 
                 progesterone 
               
               
                   
                 AKT1 
                 PP 
                 protein serine/ 
               
               
                   
                   
                   
                 theronine kinase 
               
               
                   
                 AKT1 
                 PP 
                 PS 
               
               
                   
                 AKT1 
                 PP 
                 PtdIns-3. 4-P 2 
               
               
                   
                 AKT1 
                 PP 
                 RAS small monomeric 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                 AKT1 
                 PP 
                 RELA 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 37 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 AKT1 
                 PP 
                 SLC2A1 
               
               
                   
                 AKT1 
                 PP 
                 SSTR2 
               
               
                   
                 AKT1 
                 PP 
                 THPO 
               
               
                   
                 AKT1 
                 PP 
                 transmembrane receptor 
               
               
                   
                   
                   
                 protein tyrosine kinase 
               
               
                   
                 AKT1 
                 PP 
                 tumor necrosis factor 
               
               
                   
                 AKT1 
                 PP 
                 UCN 
               
               
                   
                 AKT1 
                 PP 
                 UCN3 
               
               
                   
                 AKT2 
                 PP 
                 NYOD1 
               
               
                   
                 ALB 
                 PP 
                 CAV1 
               
               
                   
                 ALK 
                 PP 
                 IPN1 
               
               
                   
                 ALOK5 
                 PP 
                 TNF 
               
               
                   
                 APAF1 
                 PP 
                 TP53 
               
               
                   
                 APP 
                 PP 
                 IL18 
               
               
                   
                 APP 
                 PP 
                 STAT3 
               
               
                   
                 APP 
                 PP 
                 THF 
               
               
                   
                 APP 
                 PP 
                 THFRSF5 
               
               
                   
                 AR 
                 PP 
                 EP300 
               
               
                   
                 AR 
                 PP 
                 SRC 
               
               
                   
                 AR 
                 PP 
                 STAT5A 
               
               
                   
                 ARAF1 
                 PP 
                 EDK1 
               
               
                   
                 ARAF1 
                 PP 
                 MAP2K1 
               
               
                   
                 ARAF1 
                 PP 
                 MAP2K2 
               
               
                   
                 ARAF1 
                 PP 
                 MAPK1 
               
               
                   
                 ARAF1 
                 PP 
                 RAS small monomeric 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                 AREG 
                 PP 
                 BT1 
               
               
                   
                 ARF1P2 
                 PP 
                 RAC1 
               
               
                   
                 ARG2 
                 PP 
                 TGFB1 
               
               
                   
                 ARHGEF12 
                 PP 
                 GNA13 
               
               
                   
                 ARRB1 
                 PP 
                 MAPK3 
               
               
                   
                 ATF2 
                 PP 
                 TGFB1 
               
               
                   
                 AYP 
                 PP 
                 ADCY2 
               
               
                   
                 BAX 
                 PP 
                 BCL2L2 
               
               
                   
                 BAX 
                 PP 
                 CASP3 
               
               
                   
                 BAX 
                 PP 
                 TNFRSF6 
               
               
                   
                 BBC3 
                 PP 
                 TP53 
               
               
                   
                 BCAR1 
                 PP 
                 CRK 
               
               
                   
                 BCAR1 
                 PP 
                 EGF 
               
               
                   
                 BCAR1 
                 PP 
                 FN1 
               
               
                   
                 BCAR1 
                 PP 
                   NS 
               
               
                   
                 BCAR1 
                 PP 
                 KRAS2 
               
               
                   
                 BCAR1 
                 PP 
                 YAPK8 
               
               
                   
                 BCAR1 
                 PP 
                 SRC 
               
               
                   
                 B-cell receptor 
                 PP 
                 JUN 
               
               
                   
                 BCL2 
                 PP 
                 cAYP-dependent protein 
               
               
                   
                   
                   
                 kinase. 
               
               
                   
                 BCL2 
                 PP 
                 Phosphatidylinositol 
               
               
                   
                   
                   
                 3-kinase 
               
               
                   
                 BCL2 
                 PP 
                 POU4F1 
               
               
                   
                 BCL2 
                 PP 
                 RPS6K 
               
               
                   
                 BCL2 
                 PP 
                 STAT3 
               
               
                   
                 BCL2 
                 PP 
                 TNFRSF17 
               
               
                   
                 BCL2 
                 PP 
                 VEGF 
               
               
                   
                 BCL2L1 
                 PP 
                 STAT3 
               
               
                   
                 BCL3 
                 PP 
                 CCND1 
               
               
                   
                 BDK 
                 PP 
                 EGFR 
               
               
                   
                 BDK 
                 PP 
                 IL18 
               
               
                   
                 BDK 
                 PP 
                 IL1F8 
               
               
                   
                 BDK 
                 PP 
                 NGF8 
               
               
                   
                 BDK 
                 PP 
                 PRKCE 
               
               
                   
                 BDK 
                 PP 
                 PTGS2 
               
               
                   
                 BDK 
                 PP 
                 TAC1 
               
               
                   
                 BDNF 
                 PP 
                 CREB1 
               
               
                   
                 BDNF 
                 PP 
                 FGF2 
               
               
                   
                 BDNF 
                 PP 
                 PIPN11 
               
               
                   
                 BDNF 
                 PP 
                 VIP 
               
               
                   
                 BIRC3 
                 PP 
                 NAPK8 
               
               
                   
                 BKP2 
                 PP 
                 BCL2L1 
               
               
                   
                 BRAF 
                 PP 
                 MAP2K1 
               
               
                   
                 BRAF 
                 PP 
                 MAP2K2 
               
               
                   
                 BRAF 
                 PP 
                 MAPK1 
               
               
                   
                 BRAF 
                 PP 
                 MAPK3 
               
               
                   
                 BRAF 
                 PP 
                 NTRK1 
               
               
                   
                 BRAF 
                 PP 
                 RASGRP1 
               
               
                   
                 BRAF 
                 PP 
                 RPS6K 
               
               
                   
                 BRAF 
                 PP 
                 T-cell receptor 
               
               
                   
                   
                   
                 T3 complex 
               
               
                   
                 BRAF 
                 PP 
                 TERF2IP 
               
               
                   
                 BRCA1 
                 PP 
                 IFNG 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 38 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 BTK 
                 PP 
                 LYN 
               
               
                   
                 C5R1 
                 PP 
                 IL6 
               
               
                   
                 CALCA 
                 PP 
                 ADCY2 
               
               
                   
                 CALCA 
                 PP 
                 GCG 
               
               
                   
                 CALCA 
                 PP 
                 TGFB1 
               
               
                   
                 calcium 
                 PP 
                 PLCG1 
               
               
                   
                 calcium-dependent 
                 PP 
                 RAC1 
               
               
                   
                 cell adhesion molecule 
               
               
                   
                 calmodulin 
                 PP 
                 EGFR 
               
               
                   
                 calpain 
                 PP 
                 EGF 
               
               
                   
                 CaN-kinase II 
                 PP 
                 EGF 
               
               
                   
                 cANP 
                 PP 
                 EGFR 
               
               
                   
                 cAKP-dependent 
                 PP 
                 ADH 
               
               
                   
                 protein kinase. 
               
               
                   
                 catalyst 
               
               
                   
                 CAPG 
                 PP 
                 PLCG1 
               
               
                   
                 casein 
                 PP 
                 INS 
               
               
                   
                 CASP6 
                 PP 
                 TP53 
               
               
                   
                 CASP8 
                 PP 
                 BAX 
               
               
                   
                 CASP8 
                 PP 
                 CASP9 
               
               
                   
                 CASP8 
                 PP 
                 GYCS 
               
               
                   
                 CASP8 
                 PP 
                 TNFSF6 
               
               
                   
                 CASP9 
                 PP 
                 CASP3 
               
               
                   
                 CASP9 
                 PP 
                 effector caspase 
               
               
                   
                 CASP9 
                 PP 
                 PARP1 
               
               
                   
                 CASP9 
                 PP 
                 PTK2 
               
               
                   
                 CASP9 
                 PP 
                 TNFRSF6 
               
               
                   
                 caspase 
                 PP 
                 CDKN1A 
               
               
                   
                 caspase 
                 PP 
                 MAPK3 
               
               
                   
                 catecholamine 
                 PP 
                 Na+/K+ ATPase 
               
               
                   
                 CAV1 
                 PP 
                 CAV2 
               
               
                   
                 CAV1 
                 PP 
                 IL6 
               
               
                   
                 CBL 
                 PP 
                 EGF 
               
               
                   
                 CBL 
                 PP 
                 FH1 
               
               
                   
                 CBL 
                 PP 
                 INS 
               
               
                   
                 CBL 
                 PP 
                 KDR 
               
               
                   
                 CBL 
                 PP 
                 Phosphatidylinositol 
               
               
                   
                   
                   
                 3-kinase 
               
               
                   
                 CCL2 
                 PP 
                 IL1A 
               
               
                   
                 CCL2 
                 PP 
                 IL3 
               
               
                   
                 CCL2 
                 PP 
                 IL6 
               
               
                   
                 CCL2 
                 PP 
                 JUN 
               
               
                   
                 CCL2 
                 PP 
                 MAPK3 
               
               
                   
                 CCL2 
                 PP 
                 TNF 
               
               
                   
                 CCL21 
                 PP 
                 cANP 
               
               
                   
                 CCL4 
                 PP 
                 TNF 
               
               
                   
                 CCL5 
                 PP 
                 TFNG 
               
               
                   
                 CCL5 
                 PP 
                 MAPK14 
               
               
                   
                 CCKA2 
                 PP 
                 TP53 
               
               
                   
                 CCHD1 
                 PP 
                 CDK6 
               
               
                   
                 CCHD1 
                 PP 
                 CDKN1A 
               
               
                   
                 CCHD1 
                 PP 
                 EGF 
               
               
                   
                 CCHD1 
                 PP 
                 ERBB2 
               
               
                   
                 CCHD1 
                 PP 
                 MAP2K1 
               
               
                   
                 CCHD1 
                 PP 
                 MAPK1 
               
               
                   
                 CCHD1 
                 PP 
                 NYC 
               
               
                   
                 CCHD1 
                 PP 
                 PCAF 
               
               
                   
                 CCHD1 
                 PP 
                 platelet-derived 
               
               
                   
                   
                   
                 growth factor 
               
               
                   
                 CCHD1 
                 PP 
                 RAF1 
               
               
                   
                 CCHD1 
                 PP 
                 RBL2 
               
               
                   
                 CCKH 
                 PP 
                 CAK complex 
               
               
                   
                 CD28 
                 PP 
                 JUN 
               
               
                   
                 CD28 
                 PP 
                 MAPK8 
               
               
                   
                 CD4 
                 PP 
                 IL4 
               
               
                   
                 CD4 
                 PP 
                 IL6 
               
               
                   
                 CD44 
                 PP 
                 HGF 
               
               
                   
                 CD44 
                 PP 
                 TGFB1 
               
               
                   
                 CD48 
                 PP 
                 TFNG 
               
               
                   
                 CD5 
                 PP 
                 NAFK8 
               
               
                   
                 CD58 
                 PP 
                 IL4 
               
               
                   
                 CDC2 
                 PP 
                 CDC25C 
               
               
                   
                 CDC25A 
                 PP 
                 CCNE1 
               
               
                   
                 CDC25C 
                 PP 
                 NSLN 
               
               
                   
                 CDC42 
                 PP 
                 F2 
               
               
                   
                 CDC42 
                 PP 
                 PTK2 
               
               
                   
                 CDC42 
                 PP 
                 RAF1 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 39 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 CDH1 
                 PP 
                 NYC 
               
               
                   
                 CDK2 
                 PP 
                 OCND2 
               
               
                   
                 CDKN1A 
                 PP 
                 ERCA1 
               
               
                   
                 CDKN1A 
                 PP 
                 EGF 
               
               
                   
                 CDKN1A 
                 PP 
                 EGFR 
               
               
                   
                 CDKN1A 
                 PP 
                 FGF2 
               
               
                   
                 CDKN1A 
                 PP 
                 HDKA10 
               
               
                   
                 CDKN1A 
                 PP 
                 nap kinase 
               
               
                   
                 CDKN1A 
                 PP 
                 MAPK1 
               
               
                   
                 CDKN1A 
                 PP 
                 HTRK1 
               
               
                   
                 CDKN1A 
                 PP 
                 Nuclear factor NF 
               
               
                   
                   
                   
                 kappa 8 
               
               
                   
                 CDKN1A 
                 PP 
                 PAK1 
               
               
                   
                 CDKN1A 
                 PP 
                 Phosphatidylinositol 
               
               
                   
                   
                   
                 3-kinase 
               
               
                   
                 CDKN1A 
                 PP 
                 PKC 
               
               
                   
                 CDKN1A 
                 PP 
                 PRKCA 
               
               
                   
                 CDKN1A 
                 PP 
                 protein serine/ 
               
               
                   
                   
                   
                 threonine kinase 
               
               
                   
                 CDKN1A 
                 PP 
                 protein tyrosine kinase 
               
               
                   
                 CDKN1A 
                 PP 
                 SLC12A9 
               
               
                   
                 CDKN1A 
                 PP 
                 STAT1 
               
               
                   
                 CDKN1A 
                 PP 
                 TP73 
               
               
                   
                 CDKN1B 
                 PP 
                 CDKN1A 
               
               
                   
                 CDKN1B 
                 PP 
                 CDKN1C 
               
               
                   
                 CDKN1B 
                 PP 
                 JUN 
               
               
                   
                 CDKN1B 
                 PP 
                 NYOD1 
               
               
                   
                 CDKN1B 
                 PP 
                 SP1 
               
               
                   
                 CDKN2B 
                 PP 
                 TGFB1 
               
               
                   
                 CEBPA 
                 PP 
                 USF1 
               
               
                   
                 CEBFB 
                 PP 
                 RAS small monomeric 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                 CEBPB 
                 PP 
                 STAT3 
               
               
                   
                 CEBPB 
                 PP 
                 transcription factor 
               
               
                   
                 CEBPG 
                 PP 
                 IL6 
               
               
                   
                 choline phosphatase 
                 PP 
                 PRKCZ 
               
               
                   
                 choline phosphatase 
                 PP 
                 RHOA 
               
               
                   
                 CHUK 
                 PP 
                 1KBKB 
               
               
                   
                 CHUK 
                 PP 
                 NF-kappa8-inducing 
               
               
                   
                   
                   
                 kinase 
               
               
                   
                 CNTF 
                 PP 
                 IL6 
               
               
                   
                 CNTF 
                 PP 
                 NAPK1 
               
               
                   
                 CNTF 
                 PP 
                 NAPK3 
               
               
                   
                 CREB1 
                 PP 
                 ADCY2 
               
               
                   
                 CREB1 
                 PP 
                 EP300 
               
               
                   
                 CREB1 
                 PP 
                 GC6 
               
               
                   
                 CREB1 
                 PP 
                 IL2 
               
               
                   
                 CREB1 
                 PP 
                 NAPK14 
               
               
                   
                 CREB1 
                 PP 
                 POKC 
               
               
                   
                 CREB1 
                 PP 
                 RAC1 
               
               
                   
                 CREB1 
                 PP 
                 SRC 
               
               
                   
                 CREB1 
                 PP 
                 TGFB1 
               
               
                   
                 CRH 
                 PP 
                 ILG 
               
               
                   
                 CRH 
                 PP 
                 TNF 
               
               
                   
                 CRHR1 
                 PP 
                 MAPK3 
               
               
                   
                 CRK 
                 PP 
                 DOCK1 
               
               
                   
                 CRK 
                 PP 
                 EGF 
               
               
                   
                 CRK 
                 PP 
                 NAPK1 
               
               
                   
                 CRK 
                 PP 
                 NGFB 
               
               
                   
                 CRK 
                 PP 
                 platelet-derived 
               
               
                   
                   
                   
                 growth factor 
               
               
                   
                 CRK 
                 PP 
                 PKN 
               
               
                   
                 CRK 
                 PP 
                 RAS small monomeric 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                 CRK 
                 PP 
                 RPS6K 
               
               
                   
                 CRK 
                 PP 
                 src family 
               
               
                   
                 CRK 
                 PP 
                 T-cell receptor 
               
               
                   
                   
                   
                 T3 complex 
               
               
                   
                 CRKL 
                 PP 
                 EGF 
               
               
                   
                 CRKL 
                 PP 
                 RAPGEF1 
               
               
                   
                 CSF1 
                 PP 
                 CCL2 
               
               
                   
                 CSF1 
                 PP 
                 CSF2 
               
               
                   
                 CSF1 
                 PP 
                 IL6 
               
               
                   
                 CSF1 
                 PP 
                 NAPK1 
               
               
                   
                 CSF1 
                 PP 
                 STAT3 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 40 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 CSF2 
                 PP 
                 IL2 
               
               
                   
                 CSF2 
                 PP 
                 JAK2 
               
               
                   
                 CSF2 
                 PP 
                 JUN 
               
               
                   
                 CSF2 
                 PP 
                 KITL6 
               
               
                   
                 CSF2 
                 PP 
                 LYN 
               
               
                   
                 CSF2 
                 PP 
                 NAPK14 
               
               
                   
                 CSF2 
                 PP 
                 PTPN11 
               
               
                   
                 CSF2 
                 PP 
                 RAF1 
               
               
                   
                 CSF2 
                 PP 
                 STAT5A 
               
               
                   
                 CSF2 
                 PP 
                 TNF 
               
               
                   
                 CSF2 
                 PP 
                 VEGF 
               
               
                   
                 CSF3 
                 PP 
                 CEBPB 
               
               
                   
                 CSF3 
                 PP 
                 CISH 
               
               
                   
                 CSF3 
                 PP 
                 CSF3R 
               
               
                   
                 CSF3 
                 PP 
                 IL1 
               
               
                   
                 CSF3 
                 PP 
                 IL6 
               
               
                   
                 CSF3 
                 PP 
                 ITGA11 
               
               
                   
                 CSF3 
                 PP 
                 ITGAX 
               
               
                   
                 CSF3 
                 PP 
                 ITGB2 
               
               
                   
                 CSF3 
                 PP 
                 JAK1 
               
               
                   
                 CSF3 
                 PP 
                 JAK2 
               
               
                   
                 CSF3 
                 PP 
                 LYN 
               
               
                   
                 CSF3 
                 PP 
                 RAF1 
               
               
                   
                 CSF3 
                 PP 
                 RPS6K 
               
               
                   
                 CSF3 
                 PP 
                 STAT1 
               
               
                   
                 CSF3 
                 PP 
                 TYK2 
               
               
                   
                 CTGF 
                 PP 
                 FH1 
               
               
                   
                 CTGF 
                 PP 
                 TGFB1 
               
               
                   
                 CTGF 
                 PP 
                 VEGF 
               
               
                   
                 CTNNB1 
                 PP 
                 LEF 
               
               
                   
                 CTNNB1 
                 PP 
                 LEF1 
               
               
                   
                 CX3CL1 
                 PP 
                 TP53 
               
               
                   
                 CXCL10 
                 PP 
                 CXCR3 
               
               
                   
                 CXCL5 
                 PP 
                 TNF 
               
               
                   
                 CXCL9 
                 PP 
                 IFNG 
               
               
                   
                 CXCR3 
                 PP 
                 VAPK1 
               
               
                   
                 cyclin 
                 PP 
                 E2F1 
               
               
                   
                 CYCS 
                 PP 
                 CASP9 
               
               
                   
                 CYCS 
                 PP 
                 effector caspase 
               
               
                   
                 CYP1A1 
                 PP 
                 CYP2B6 
               
               
                   
                 diacylglycerol 
                 PP 
                 PLC61 
               
               
                   
                 DTR 
                 PP 
                 NAPK1 
               
               
                   
                 E2F1 
                 PP 
                 CASP9 
               
               
                   
                 E2F1 
                 PP 
                 caspase 
               
               
                   
                 E2F1 
                 PP 
                 CHEK2 
               
               
                   
                 EDN1 
                 PP 
                 CKCL1 
               
               
                   
                 EDN1 
                 PP 
                 EGF 
               
               
                   
                 EDN1 
                 PP 
                 HRAS 
               
               
                   
                 EDN1 
                 PP 
                 YAPK3 
               
               
                   
                 EDN1 
                 PP 
                 NOS2A 
               
               
                   
                 EDN1 
                 PP 
                 PLA2618 
               
               
                   
                 EDN1 
                 PP 
                 RHOA 
               
               
                   
                 EDN1 
                 PP 
                 SHC1 
               
               
                   
                 EDN1 
                 PP 
                 VEGF 
               
               
                   
                 EEF2X 
                 PP 
                 FRAP1 
               
               
                   
                 EGF 
                 PP 
                 ABL1 
               
               
                   
                 EGF 
                 PP 
                 adrenoceptor 
               
               
                   
                 EGF 
                 PP 
                 AGTR1 
               
               
                   
                 EGF 
                 PP 
                 ALB 
               
               
                   
                 EGF 
                 PP 
                 ARF6 
               
               
                   
                 EGF 
                 PP 
                 CDC42 
               
               
                   
                 EGF 
                 PP 
                 CISH 
               
               
                   
                 EGF 
                 PP 
                 DNN1 
               
               
                   
                 EGF 
                 PP 
                 DTR 
               
               
                   
                 EGF 
                 PP 
                 ELK1 
               
               
                   
                 EGF 
                 PP 
                 ERBE3 
               
               
                   
                 EGF 
                 PP 
                 ERK activator kinase 
               
               
                   
                 EGF 
                 PP 
                 FN1 
               
               
                   
                 EGF 
                 PP 
                 FOS 
               
               
                   
                 EGF 
                 PP 
                 GAB1 
               
               
                   
                 EGF 
                 PP 
                 GH1 
               
               
                   
                 EGF 
                 PP 
                 K202 
               
               
                   
                 EGF 
                 PP 
                 IGF1 
               
               
                   
                 EGF 
                 PP 
                 IL6 
               
               
                   
                 EGF 
                 PP 
                 NAP2K1 
               
               
                   
                 EGF 
                 PP 
                 NAPK3 
               
               
                   
                 EGF 
                 PP 
                 NYC 
               
               
                   
                 EGF 
                 PP 
                 PTK2 
               
               
                   
                 EGF 
                 PP 
                 PTPN11 
               
               
                   
                 EGF 
                 PP 
                 RAF1 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 41 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 EGF 
                 PP 
                 SHC1 
               
               
                   
                 EGF 
                 PP 
                 SRC 
               
               
                   
                 EGF 
                 PP 
                 STAT3 
               
               
                   
                 EGF 
                 PP 
                 TGFA 
               
               
                   
                 EGFR 
                 PP 
                 AREG 
               
               
                   
                 EGFR 
                 PP 
                 DTR 
               
               
                   
                 EGFR 
                 PP 
                 EPS15 
               
               
                   
                 EGFR 
                 PP 
                 ERBB4 
               
               
                   
                 EGFR 
                 PP 
                 FN1 
               
               
                   
                 EGFR 
                 PP 
                 GAB1 
               
               
                   
                 EGFR 
                 PP 
                 nap kinase 
               
               
                   
                 EGFR 
                 PP 
                 NAPK3 
               
               
                   
                 EGFR 
                 PP 
                 NAP2 
               
               
                   
                 EGFR 
                 PP 
                 Nuclear factor NF 
               
               
                   
                   
                   
                 kappa B 
               
               
                   
                 EGFR 
                 PP 
                 PGE2 
               
               
                   
                 EGFR 
                 PP 
                 PKC 
               
               
                   
                 EGFR 
                 PP 
                 PLCG1 
               
               
                   
                 EGFR 
                 PP 
                 PTK2 
               
               
                   
                 EGFR 
                 PP 
                 PTK28 
               
               
                   
                 EGFR 
                 PP 
                 SOS1 
               
               
                   
                 EGFR 
                 PP 
                 SRC 
               
               
                   
                 EGFR 
                 PP 
                 TGFB1 
               
               
                   
                 EGFR 
                 PP 
                 UBE2L3 
               
               
                   
                 EGR1 
                 PP 
                 FGF2 
               
               
                   
                 EGR1 
                 PP 
                 IGF2 
               
               
                   
                 EGR1 
                 PP 
                 IL3 
               
               
                   
                 EGR1 
                 PP 
                 interleukin-1 receptor 
               
               
                   
                   
                   
                 ligand 
               
               
                   
                 EGR1 
                 PP 
                 NTSR1 
               
               
                   
                 EGR1 
                 PP 
                 PDGFA 
               
               
                   
                 EGR1 
                 PP 
                 platelet-derived 
               
               
                   
                   
                   
                 growth factor 
               
               
                   
                 EGR1 
                 PP 
                 RPSGK 
               
               
                   
                 EGR1 
                 PP 
                 TGFB1 
               
               
                   
                 EGR1 
                 PP 
                 TNF 
               
               
                   
                 ELF3 
                 PP 
                 ERBB2 
               
               
                   
                 ELK1 
                 PP 
                 JUN 
               
               
                   
                 ELK1 
                 PP 
                 HAPK3 
               
               
                   
                 ELK1 
                 PP 
                 HAPK8 
               
               
                   
                 ELK1 
                 PP 
                 P2RY1 
               
               
                   
                 ELK1 
                 PP 
                 SAP kinase 
               
               
                   
                 endothelin 
                 PP 
                 IL6 
               
               
                   
                 EKTPD2 
                 PP 
                 EGF 
               
               
                   
                 EP300 
                 PP 
                 TGFB1 
               
               
                   
                 EPHA3 
                 PP 
                 VEGF 
               
               
                   
                 EPHB1 
                 PP 
                 HAPK1 
               
               
                   
                 EPHB1 
                 PP 
                 HAPK8 
               
               
                   
                 EPX 
                 PP 
                 CSF3 
               
               
                   
                 ERBB2 
                 PP 
                 GRE2 
               
               
                   
                 ERBB2 
                 PP 
                 Nuclear factor NF 
               
               
                   
                   
                   
                 kappa B 
               
               
                   
                 ERB32 
                 PP 
                 PTGS2 
               
               
                   
                 ERB84 
                 PP 
                 ERBB2 
               
               
                   
                 ERK activator kinase 
                 PP 
                 HAPK8 
               
               
                   
                 ESR1 
                 PP 
                 AKT2 
               
               
                   
                 ESR1 
                 PP 
                 JUN 
               
               
                   
                 ESR1 
                 PP 
                 HAPK1 
               
               
                   
                 ESR1 
                 PP 
                 SP1 
               
               
                   
                 ETS1 
                 PP 
                 COLIA2 
               
               
                   
                 ETS1 
                 PP 
                 ETS2 
               
               
                   
                 ETS1 
                 PP 
                 PPARA 
               
               
                   
                 ETS1 
                 PP 
                 VEGF 
               
               
                   
                 ETS2 
                 PP 
                 CGHD1 
               
               
                   
                 ETY1 
                 PP 
                 ERBB2 
               
               
                   
                 F2 
                 PP 
                 ICAH1 
               
               
                   
                 F2 
                 PP 
                 HAPK3 
               
               
                   
                 F2 
                 PP 
                 Phosphatidylinositol 
               
               
                   
                   
                   
                 3-kinase 
               
               
                   
                 F2 
                 PP 
                 PLAUR 
               
               
                   
                 F2 
                 PP 
                 PLCG1 
               
               
                   
                 F2 
                 PP 
                 PRKCA 
               
               
                   
                 F2 
                 PP 
                 protein phosphatase 1 
               
               
                   
                 F2 
                 PP 
                 PTK2B 
               
               
                   
                 F2 
                 PP 
                 SHC1 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 42 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 F2R 
                 PP 
                 ACRBK2 
               
               
                   
                 F2R 
                 PP 
                 beta-n- 
               
               
                   
                   
                   
                 acetylglucoseninidase 
               
               
                   
                 F2R 
                 PP 
                 EGF 
               
               
                   
                 F2R 
                 PP 
                 ICAN1 
               
               
                   
                 F2R 
                 PP 
                 peptide receptor, 
               
               
                   
                   
                   
                 G-protein coupled 
               
               
                   
                 F2R 
                 PP 
                 Phosphatidylinositol 
               
               
                   
                   
                   
                 3-kinase 
               
               
                   
                 F2R 
                 PP 
                 PLAT 
               
               
                   
                 F2R 
                 PP 
                 RAP1B 
               
               
                   
                 F2R 
                 PP 
                 SELP 
               
               
                   
                 F2R 
                 PP 
                 SHC1 
               
               
                   
                 F2R 
                 PP 
                 TXNL5 
               
               
                   
                 F2RL1 
                 PP 
                 F2R 
               
               
                   
                 F2RL1 
                 PP 
                 peptide receptor, 
               
               
                   
                   
                   
                 G-protein coupled 
               
               
                   
                 F2RL1 
                 PP 
                 phospholipase C 
               
               
                   
                 F3 
                 PP 
                 ALB 
               
               
                   
                 F3 
                 PP 
                 F2 
               
               
                   
                 F3 
                 PP 
                 IL18 
               
               
                   
                 FCER2 
                 PP 
                 IL6 
               
               
                   
                 Ferritin 
                 PP 
                 IFNG 
               
               
                   
                 FGF1 
                 PP 
                 Hap kinase 
               
               
                   
                 FGF1 
                 PP 
                 NGFB 
               
               
                   
                 FGF1 
                 PP 
                 PLK3 
               
               
                   
                 FGF1 
                 PP 
                 RPS6K 
               
               
                   
                 FGF18 
                 PP 
                 ERK activator kinase 
               
               
                   
                 FGF2 
                 PP 
                 BCL2L1 
               
               
                   
                 FGF2 
                 PP 
                 CD44 
               
               
                   
                 FGF2 
                 PP 
                 JUN 
               
               
                   
                 FGF2 
                 PP 
                 NPPA 
               
               
                   
                 FGF2 
                 PP 
                 PLOG1 
               
               
                   
                 FGF2 
                 PP 
                 PRL 
               
               
                   
                 FGF2 
                 PP 
                 PTGS2 
               
               
                   
                 FGF2 
                 PP 
                 PTPH11 
               
               
                   
                 FGF2 
                 PP 
                 TGFB1 
               
               
                   
                 FGF2 
                 PP 
                 VEGF 
               
               
                   
                 FGF7 
                 PP 
                 HAPK1 
               
               
                   
                 fibroblast growth 
                 PP 
                 TNF 
               
               
                   
                 factor 
               
               
                   
                 FN1 
                 PP 
                 AGT 
               
               
                   
                 FN1 
                 PP 
                 EDN1 
               
               
                   
                 FN1 
                 PP 
                 HAP2K1 
               
               
                   
                 FN1 
                 PP 
                 HAPK1 
               
               
                   
                 FN1 
                 PP 
                 HAP9 
               
               
                   
                 FN1 
                 PP 
                 PTK2 
               
               
                   
                 FN1 
                 PP 
                 RHOA 
               
               
                   
                 FN1 
                 PP 
                 VEGF 
               
               
                   
                 FOS 
                 PP 
                 AGT 
               
               
                   
                 FOS 
                 PP 
                 BDNF 
               
               
                   
                 FOS 
                 PP 
                 CREB1 
               
               
                   
                 FOS 
                 PP 
                 ELK1 
               
               
                   
                 FOS 
                 PP 
                 JUNB 
               
               
                   
                 FOS 
                 PP 
                 VAPK8 
               
               
                   
                 FOS 
                 PP 
                 ODC1 
               
               
                   
                 FOS 
                 PP 
                 RAF1 
               
               
                   
                 FOS 
                 PP 
                 RPSGKB1 
               
               
                   
                 FOS 
                 PP 
                 SRG 
               
               
                   
                 FOS 
                 PP 
                 STAT3 
               
               
                   
                 FOSB 
                 PP 
                 JUN 
               
               
                   
                 FYN 
                 PP 
                 ELK1 
               
               
                   
                 FYN 
                 PP 
                 PLCG1 
               
               
                   
                 g protein 
                 PP 
                 EGFR 
               
               
                   
                 GA17 
                 PP 
                 TFNG 
               
               
                   
                 GAB1 
                 PP 
                 HGF 
               
               
                   
                 GAB1 
                 PP 
                 nap kinase 
               
               
                   
                 GAB1 
                 PP 
                 Phosphatidylinositol 
               
               
                   
                   
                   
                 3-kinase 
               
               
                   
                 GAB1 
                 PP 
                 platelet-derived 
               
               
                   
                   
                   
                 growth factor 
               
               
                   
                 GADD45A 
                 PP 
                 COKN1A 
               
               
                   
                 GADD45A 
                 PP 
                 NAPK8 
               
               
                   
                 GAP 
                 PP 
                 NAPK1 
               
               
                   
                 GAS 
                 PP 
                 THF 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 43 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 GCG 
                 PP 
                 ADCY2 
               
               
                   
                 GCG 
                 PP 
                 NAP2K1 
               
               
                   
                 GCG 
                 PP 
                 NAPK1 
               
               
                   
                 GCG 
                 PP 
                 NAPK3 
               
               
                   
                 GCG 
                 PP 
                 PONC 
               
               
                   
                 GDNF 
                 PP 
                 HAPK1 
               
               
                   
                 GEF 
                 PP 
                 RAC1 
               
               
                   
                 GH1 
                 PP 
                 CEBP3 
               
               
                   
                 GH1 
                 PP 
                 GNRH1 
               
               
                   
                 GH1 
                 PP 
                 IRS1 
               
               
                   
                 GH1 
                 PP 
                 JAK2 
               
               
                   
                 GJAI 
                 PP 
                 NAPK3 
               
               
                   
                 GLI 
                 PP 
                 GLI2 
               
               
                   
                 glucose 
                 PP 
                 PPARGC1A 
               
               
                   
                 glutamate receptor 
                 PP 
                 NAPK1 
               
               
                   
                 GNA12 
                 PP 
                 NAPK3 
               
               
                   
                 GNAO 
                 PP 
                 RHOA 
               
               
                   
                 GNRH1 
                 PP 
                 ADCYAP1 
               
               
                   
                 GNRH1 
                 PP 
                 EGFR 
               
               
                   
                 GNRHR 
                 PP 
                 EGFR 
               
               
                   
                 GNRHR 
                 PP 
                 NAPK1 
               
               
                   
                 GRB2 
                 PP 
                 BCR 
               
               
                   
                 GRB2 
                 PP 
                 EGF 
               
               
                   
                 GRB2 
                 PP 
                 LPA 
               
               
                   
                 GRB2 
                 PP 
                 SHC1 
               
               
                   
                 Group] cetabotropic 
                 PP 
                 NAPK3 
               
               
                   
                 glutamate receptor 
                 PP 
                 JUN 
               
               
                   
                 growth factor 
               
               
                   
                 receptor 
                 PP 
                 BCL2L11 
               
               
                   
                 GSK3B 
               
               
                   
                 GSK3B 
                 PP 
                 BDNF 
               
               
                   
                 GSK3B 
                 PP 
                 NAP2K1 
               
               
                   
                 GTPase 
                 PP 
                 GNAO 
               
               
                   
                 guanine nucleotide 
                 PP 
                 RAC1 
               
               
                   
                 exchange factor 
               
               
                   
                 GYPC 
                 PP 
                 IL6 
               
               
                   
                 H+/K+ ATPase 
                 PP 
                 AKT1 
               
               
                   
                 H2O2 
                 PP 
                 POGFB 
               
               
                   
                 H2O2 
                 PP 
                 PLGG1 
               
               
                   
                 HAND1 
                 PP 
                 IFNG 
               
               
                   
                 HGF 
                 PP 
                 IL6 
               
               
                   
                 HGF 
                 PP 
                 NGFB 
               
               
                   
                 HGF 
                 PP 
                 NOS2A 
               
               
                   
                 HGF 
                 PP 
                 PLAU 
               
               
                   
                 HGF 
                 PP 
                 PLAUR 
               
               
                   
                 HGF 
                 PP 
                 PTPH11 
               
               
                   
                 HGF 
                 PP 
                 SP1 
               
               
                   
                 HGF 
                 PP 
                 SRC 
               
               
                   
                 HGF 
                 PP 
                 VEGF 
               
               
                   
                 HGS 
                 PP 
                 EGF 
               
               
                   
                 HIFIA 
                 PP 
                 GSK38 
               
               
                   
                 HLA-A 
                 PP 
                 IFNG 
               
               
                   
                 HNOX1 
                 PP 
                 IL6 
               
               
                   
                 HNOX1 
                 PP 
                 NAPK14 
               
               
                   
                 HNOX1 
                 PP 
                 NAPK3 
               
               
                   
                 HRAS 
                 PP 
                 EGFR 
               
               
                   
                 HRAS 
                 PP 
                 KRT18 
               
               
                   
                 HRAS 
                 PP 
                 PLC61 
               
               
                   
                 HSPA4 
                 PP 
                 HSPCA 
               
               
                   
                 HSPB2 
                 PP 
                 TNF 
               
               
                   
                 HSPCA 
                 PP 
                 NOS3 
               
               
                   
                 HSPCA 
                 PP 
                 STAT3 
               
               
                   
                 HSFCA 
                 PP 
                 VEGF 
               
               
                   
                 HSPE1 
                 PP 
                 HSPD1 
               
               
                   
                 HTATIP 
                 PP 
                 IL6 
               
               
                   
                 ICAN1 
                 PP 
                 CCL5 
               
               
                   
                 ICAN1 
                 PP 
                 FOS 
               
               
                   
                 ICAN1 
                 PP 
                 IL2 
               
               
                   
                 ICAN1 
                 PP 
                 HAPK8 
               
               
                   
                 ICAN1 
                 PP 
                 STAT1 
               
               
                   
                 IER2 
                 PP 
                 JUN 
               
               
                   
                 IER2 
                 PP 
                 INF 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 44 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 IFNG 
                 PP 
                 B2H 
               
               
                   
                 IFNG 
                 PP 
                 B7H3 
               
               
                   
                 IFNG 
                 PP 
                 GASP1 
               
               
                   
                 IFNG 
                 PP 
                 CCR5 
               
               
                   
                 IFNG 
                 PP 
                 CCR6 
               
               
                   
                 IFNG 
                 PP 
                 CD69 
               
               
                   
                 IFNG 
                 PP 
                 CD86 
               
               
                   
                 IFNG 
                 PP 
                 COK5R1 
               
               
                   
                 IFNG 
                 PP 
                 CEACAY5 
               
               
                   
                 IFNG 
                 PP 
                 CK3CL1 
               
               
                   
                 IFNG 
                 PP 
                 CKCL16 
               
               
                   
                 IFNG 
                 PP 
                 DPP4 
               
               
                   
                 IFNG 
                 PP 
                 FCGR1A 
               
               
                   
                 IFNG 
                 PP 
                 HLA-B 
               
               
                   
                 IFNG 
                 PP 
                 HLA-E 
               
               
                   
                 IFNG 
                 PP 
                 HSPA4 
               
               
                   
                 IFNG 
                 PP 
                 IL15 
               
               
                   
                 IFNG 
                 PP 
                 IL-18 receptor 
               
               
                   
                 IFNG 
                 PP 
                 IL1F8 
               
               
                   
                 IFNG 
                 PP 
                 IL2RB 
               
               
                   
                 IFNG 
                 PP 
                 IRF1 
               
               
                   
                 IFNG 
                 PP 
                 JAK2 
               
               
                   
                 IFNG 
                 PP 
                 LTA 
               
               
                   
                 IFNG 
                 PP 
                 LY96 
               
               
                   
                 IFNG 
                 PP 
                 neopterin 
               
               
                   
                 IFNG 
                 PP 
                 NOS2A 
               
               
                   
                 IFNG 
                 PP 
                 OAS1 
               
               
                   
                 IFNG 
                 PP 
                 PIH1 
               
               
                   
                 IFNG 
                 PP 
                 PLA2618 
               
               
                   
                 IFNG 
                 PP 
                 RA 
               
               
                   
                 IFNG 
                 PP 
                 RPS6K 
               
               
                   
                 IFNG 
                 PP 
                 SELL 
               
               
                   
                 IFNG 
                 PP 
                 SFTPA1 
               
               
                   
                 IFNG 
                 PP 
                 SNN2 
               
               
                   
                 IFNG 
                 PP 
                 STAT3 
               
               
                   
                 IFNG 
                 PP 
                 STAT5A 
               
               
                   
                 IFNG 
                 PP 
                 TACR1 
               
               
                   
                 IFNG 
                 PP 
                 TBK21 
               
               
                   
                 IFNG 
                 PP 
                 TKFRSF6 
               
               
                   
                 IFKG 
                 PP 
                 TRIY8 
               
               
                   
                 IGBPI 
                 PP 
                 CCND1 
               
               
                   
                 IGF1 
                 PP 
                 BCL2 
               
               
                   
                 IGF1 
                 PP 
                 BDNF 
               
               
                   
                 IGF1 
                 PP 
                 CCNA2 
               
               
                   
                 IGF1 
                 PP 
                 CRK 
               
               
                   
                 IGF1 
                 PP 
                 EGFR 
               
               
                   
                 IGF1 
                 PP 
                 FOS 
               
               
                   
                 IGF1 
                 PP 
                 VAPK3 
               
               
                   
                 IGF1 
                 PP 
                 OXT 
               
               
                   
                 IGF1 
                 PP 
                 POYC 
               
               
                   
                 IGF1 
                 PP 
                 PRL 
               
               
                   
                 IGF1 
                 PP 
                 PTGS2 
               
               
                   
                 IGF1 
                 PP 
                 PTK2 
               
               
                   
                 IGF1 
                 PP 
                 PTPN11 
               
               
                   
                 IGF1 
                 PP 
                 RAF1 
               
               
                   
                 IGF1 
                 PP 
                 SHC1 
               
               
                   
                 IGF1 
                 PP 
                 SRC 
               
               
                   
                 IGF1R 
                 PP 
                 IGF1 
               
               
                   
                 IGFBP3 
                 PP 
                 IP53 
               
               
                   
                 IHH 
                 PP 
                 KAPK3 
               
               
                   
                 IkappaB kinase 
                 PP 
                 CHUK 
               
               
                   
                 IL1 
                 PP 
                 ECR1 
               
               
                   
                 IL1 
                 PP 
                 IFNG 
               
               
                   
                 IL1 
                 PP 
                 IL6 
               
               
                   
                 IL1 
                 PP 
                 YAPK1 
               
               
                   
                 IL10 
                 PP 
                 POYC 
               
               
                   
                 IL13 
                 PP 
                 IL2 
               
               
                   
                 IL13 
                 PP 
                 IL3 
               
               
                   
                 IL13 
                 PP 
                 IL5 
               
               
                   
                 IL17 
                 PP 
                 TNF 
               
               
                   
                 IL18 
                 PP 
                 IFNG 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 45 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 IL1A 
                 PP 
                 CGL5 
               
               
                   
                 IL1A 
                 PP 
                 CSF2 
               
               
                   
                 IL1A 
                 PP 
                 CXCL10 
               
               
                   
                 IL1A 
                 PP 
                 F2 
               
               
                   
                 IL1A 
                 PP 
                 FNI 
               
               
                   
                 IL1A 
                 PP 
                 HGF 
               
               
                   
                 IL1A 
                 PP 
                 IL1B 
               
               
                   
                 IL1A 
                 PP 
                 IL1F8 
               
               
                   
                 IL1A 
                 PP 
                 NFKBIA 
               
               
                   
                 IL1A 
                 PP 
                 NGFB 
               
               
                   
                 IL1B 
                 PP 
                 CEBPB 
               
               
                   
                 IL1B 
                 PP 
                 CSF1 
               
               
                   
                 IL1B 
                 PP 
                 CSF2 
               
               
                   
                 IL1B 
                 PP 
                 EDNI 
               
               
                   
                 IL1B 
                 PP 
                 HGF 
               
               
                   
                 IL1B 
                 PP 
                 HSPA4 
               
               
                   
                 IL1B 
                 PP 
                 IL6 
               
               
                   
                 IL1B 
                 PP 
                 KIILG 
               
               
                   
                 IL1B 
                 PP 
                 NAPK1 
               
               
                   
                 IL1B 
                 PP 
                 NAPK14 
               
               
                   
                 IL1B 
                 PP 
                 NAPK3 
               
               
                   
                 IL1B 
                 PP 
                 NAPK8 
               
               
                   
                 IL1B 
                 PP 
                 TAC1 
               
               
                   
                 IL1B 
                 PP 
                 TNFRSF6 
               
               
                   
                 IL1F8 
                 PP 
                 AKT1 
               
               
                   
                 IL1F8 
                 PP 
                 CD44 
               
               
                   
                 IL1F8 
                 PP 
                 EGRI 
               
               
                   
                 IL1F8 
                 PP 
                 FOS 
               
               
                   
                 IL1F8 
                 PP 
                 NAPK14 
               
               
                   
                 IL1F8 
                 PP 
                 TNFRSF5 
               
               
                   
                 IL1F8 
                 PP 
                 VCAN1 
               
               
                   
                 IL2 
                 PP 
                 AKTI 
               
               
                   
                 IL2 
                 PP 
                 CD4 
               
               
                   
                 IL2 
                 PP 
                 CO44 
               
               
                   
                 IL2 
                 PP 
                 CSF1 
               
               
                   
                 IL2 
                 PP 
                 GRB2 
               
               
                   
                 IL2 
                 PP 
                 HRAS 
               
               
                   
                 IL2 
                 PP 
                 IL1B 
               
               
                   
                 IL2 
                 PP 
                 JUN 
               
               
                   
                 IL2 
                 PP 
                 KITLG 
               
               
                   
                 IL2 
                 PP 
                 NAPK1 
               
               
                   
                 IL2 
                 PP 
                 NAPK3 
               
               
                   
                 IL2 
                 PP 
                 PLAUR 
               
               
                   
                 IL2 
                 PP 
                 PLCG1 
               
               
                   
                 IL2 
                 PP 
                 PONC 
               
               
                   
                 IL2 
                 PP 
                 RAF1 
               
               
                   
                 IL2 
                 PP 
                 SHG1 
               
               
                   
                 IL2 
                 PP 
                 STAT5A 
               
               
                   
                 IL2 
                 PP 
                 TNFRSF5 
               
               
                   
                 IL2 
                 PP 
                 TNFSF6 
               
               
                   
                 IL24 
                 PP 
                 IL20RB 
               
               
                   
                 IL3 
                 PP 
                 AKTI 
               
               
                   
                 IL3 
                 PP 
                 CBL 
               
               
                   
                 IL3 
                 PP 
                 CSF2 
               
               
                   
                 IL3 
                 PP 
                 ILIA 
               
               
                   
                 IL3 
                 PP 
                 ILIB 
               
               
                   
                 IL3 
                 PP 
                 IL6 
               
               
                   
                 IL3 
                 PP 
                 JAK2 
               
               
                   
                 IL3 
                 PP 
                 LYN 
               
               
                   
                 IL3 
                 PP 
                 NAPK1 
               
               
                   
                 IL3 
                 PP 
                 NAPK8 
               
               
                   
                 IL3 
                 PP 
                 PTPN11 
               
               
                   
                 IL3 
                 PP 
                 SHG1 
               
               
                   
                 IL4 
                 PP 
                 IRS1 
               
               
                   
                 IL4 
                 PP 
                 NAPK14 
               
               
                   
                 IL4 
                 PP 
                 PLCG1 
               
               
                   
                 IL4 
                 PP 
                 TNFRSF5 
               
               
                   
                 IL4 
                 PP 
                 VCAN1 
               
               
                   
                 IL5 
                 PP 
                 VCAN1 
               
               
                   
                 IL5 
                 PP 
                 ILIB 
               
               
                   
                 IL5 
                 PP 
                 JAK2 
               
               
                   
                 IL5 
                 PP 
                 JUN 
               
               
                   
                 IL5 
                 PP 
                 NAPK3 
               
               
                   
                 IL5 
                 PP 
                 SHC1 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 46 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 IL6 
                 PP 
                 A2H 
               
               
                   
                 IL6 
                 PP 
                 ACP1 
               
               
                   
                 IL6 
                 PP 
                 AGT 
               
               
                   
                 IL6 
                 PP 
                 AKT1 
               
               
                   
                 IL6 
                 PP 
                 APP 
               
               
                   
                 IL6 
                 PP 
                 AREG 
               
               
                   
                 IL6 
                 PP 
                 cAMP 
               
               
                   
                 IL6 
                 PP 
                 CD14 
               
               
                   
                 IL6 
                 PP 
                 CEBPD 
               
               
                   
                 IL6 
                 PP 
                 CRP 
               
               
                   
                 IL6 
                 PP 
                 CSF2 
               
               
                   
                 IL6 
                 PP 
                 EBP 
               
               
                   
                 IL6 
                 PP 
                 EDN1 
               
               
                   
                 IL6 
                 PP 
                 ELA2 
               
               
                   
                 IL6 
                 PP 
                 F3 
               
               
                   
                 IL6 
                 PP 
                 FCGR3A 
               
               
                   
                 IL6 
                 PP 
                 FGF7 
               
               
                   
                 IL6 
                 PP 
                 FH1 
               
               
                   
                 IL6 
                 PP 
                 FOS 
               
               
                   
                 IL6 
                 PP 
                 GZMA 
               
               
                   
                 IL6 
                 PP 
                 H2O2 
               
               
                   
                 IL6 
                 PP 
                 hemoglobin 
               
               
                   
                 IL6 
                 PP 
                 histamine 
               
               
                   
                 IL6 
                 PP 
                 HSPB2 
               
               
                   
                 IL6 
                 PP 
                 ICAN1 
               
               
                   
                 IL6 
                 PP 
                 TGF1 
               
               
                   
                 IL6 
                 PP 
                 IL1A 
               
               
                   
                 IL6 
                 PP 
                 IL2 
               
               
                   
                 IL6 
                 PP 
                 IL6R 
               
               
                   
                 IL6 
                 PP 
                 IL8 
               
               
                   
                 IL6 
                 PP 
                 IILH4 
               
               
                   
                 IL6 
                 PP 
                 KIT 
               
               
                   
                 IL6 
                 PP 
                 lactate 
               
               
                   
                 IL6 
                 PP 
                 LIF 
               
               
                   
                 IL6 
                 PP 
                 LTB4 
               
               
                   
                 IL6 
                 PP 
                 MAPK3 
               
               
                   
                 IL6 
                 PP 
                 YHC class II complex 
               
               
                   
                 IL6 
                 PP 
                 YHC class II protein 
               
               
                   
                 IL6 
                 PP 
                 NOS2A 
               
               
                   
                 IL6 
                 PP 
                 PGE1 
               
               
                   
                 IL6 
                 PP 
                 PKG 
               
               
                   
                 IL6 
                 PP 
                 PLA2G10 
               
               
                   
                 IL6 
                 PP 
                 PHA 
               
               
                   
                 IL6 
                 PP 
                 PTGS1 
               
               
                   
                 IL6 
                 PP 
                 PTGS2 
               
               
                   
                 IL6 
                 PP 
                 PTPRC 
               
               
                   
                 IL6 
                 PP 
                 RAS small monomeric 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                 IL6 
                 PP 
                 SLC12A4 
               
               
                   
                 IL6 
                 PP 
                 STAT1 
               
               
                   
                 IL6 
                 PP 
                 TAC1 
               
               
                   
                 IL6 
                 PP 
                 TNFRSF1A 
               
               
                   
                 IL6 
                 PP 
                 TNFRSF5 
               
               
                   
                 IL6 
                 PP 
                 TNFSF11 
               
               
                   
                 IL6 
                 PP 
                 TRAF3 
               
               
                   
                 IL6 
                 PP 
                 TYK2 
               
               
                   
                 IL6 
                 PP 
                 VEGF 
               
               
                   
                 IL6ST 
                 PP 
                 CDKN1A 
               
               
                   
                 IL8 
                 PP 
                 CEBPB 
               
               
                   
                 IL8 
                 PP 
                 CSF3 
               
               
                   
                 IL8 
                 PP 
                 EDN1 
               
               
                   
                 IL8 
                 PP 
                 EGFR 
               
               
                   
                 IL8 
                 PP 
                 FGF2 
               
               
                   
                 IL8 
                 PP 
                 IL1A 
               
               
                   
                 IL8 
                 PP 
                 MAPK8 
               
               
                   
                 IL8 
                 PP 
                 POYC 
               
               
                   
                 IL8 
                 PP 
                 TAC1 
               
               
                   
                 IL8 
                 PP 
                 TGFA 
               
               
                   
                 IL8 
                 PP 
                 TNFSF6 
               
               
                   
                 IL8 
                 PP 
                 VEGF 
               
               
                   
                 IL8RA 
                 PP 
                 IL8RB 
               
               
                   
                 IL8RB 
                 PP 
                 CXCL1 
               
               
                   
                 ILF 
                 PP 
                 IL8 
               
               
                   
                 ILK 
                 PP 
                 TGFB1 
               
               
                   
                 I HBA 
                 PP 
                 TGFB1 
               
               
                   
                 inositol lipids 
                 PP 
                 AXT1 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 47 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 INS 
                 PP 
                 ADRB2 
               
               
                   
                 INS 
                 PP 
                 AIB 
               
               
                   
                 INS 
                 PP 
                 ANXA1 
               
               
                   
                 INS 
                 PP 
                 ARNT 
               
               
                   
                 INS 
                 PP 
                 atypical protein 
               
               
                   
                   
                   
                 kinase C 
               
               
                   
                 INS 
                 PP 
                 calmodulin 
               
               
                   
                 INS 
                 PP 
                 CDC42 
               
               
                   
                 INS 
                 PP 
                 CREB1 
               
               
                   
                 INS 
                 PP 
                 CSF1 
               
               
                   
                 INS 
                 PP 
                 EDN1 
               
               
                   
                 INS 
                 PP 
                 EGF 
               
               
                   
                 INS 
                 PP 
                 EGR1 
               
               
                   
                 INS 
                 PP 
                 estradiol 
               
               
                   
                 INS 
                 PP 
                 FGF1 
               
               
                   
                 INS 
                 PP 
                 fibroblast growth factor 
               
               
                   
                 INS 
                 PP 
                 GAS 
               
               
                   
                 INS 
                 PP 
                 GCXR 
               
               
                   
                 INS 
                 PP 
                 GRB10 
               
               
                   
                 INS 
                 PP 
                 GRB2 
               
               
                   
                 INS 
                 PP 
                 IGF1R 
               
               
                   
                 INS 
                 PP 
                 IGFBP5 
               
               
                   
                 INS 
                 PP 
                 IL1RN 
               
               
                   
                 INS 
                 PP 
                 IP3 
               
               
                   
                 INS 
                 PP 
                 IPF1 
               
               
                   
                 INS 
                 PP 
                 JAK2 
               
               
                   
                 INS 
                 PP 
                 KLK3 
               
               
                   
                 INS 
                 PP 
                 map kinase 
               
               
                   
                 INS 
                 PP 
                 MAPK1 
               
               
                   
                 INS 
                 PP 
                 HIF 
               
               
                   
                 INS 
                 PP 
                 HEK6 
               
               
                   
                 INS 
                 PP 
                 HGF8 
               
               
                   
                 INS 
                 PP 
                 Nuclear factor NF 
               
               
                   
                   
                   
                 kappa B 
               
               
                   
                 INS 
                 PP 
                 ODC1 
               
               
                   
                 INS 
                 PP 
                 OKT 
               
               
                   
                 INS 
                 PP 
                 PDYN 
               
               
                   
                 INS 
                 PP 
                 phospholipase C 
               
               
                   
                 INS 
                 PP 
                 PKC 
               
               
                   
                 INS 
                 PP 
                 PKLR 
               
               
                   
                 INS 
                 PP 
                 platelet-derived 
               
               
                   
                   
                   
                 growth facor 
               
               
                   
                 INS 
                 PP 
                 P CH 
               
               
                   
                 INS 
                 PP 
                 PONG 
               
               
                   
                 INS 
                 PP 
                 PRKCZ 
               
               
                   
                 INS 
                 PP 
                 protein phosphatase 
               
               
                   
                 INS 
                 PP 
                 protein tyrosine kinase 
               
               
                   
                 INS 
                 PP 
                 PTGDS 
               
               
                   
                 INS 
                 PP 
                 PTHLH 
               
               
                   
                 INS 
                 PP 
                 PTPN11 
               
               
                   
                 INS 
                 PP 
                 pyruvate dehydrogenase 
               
               
                   
                 INS 
                 PP 
                 RA 
               
               
                   
                 INS 
                 PP 
                 RAS small monomeric 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                 INS 
                 PP 
                 RPS6KA3 
               
               
                   
                 INS 
                 PP 
                 SOS1 
               
               
                   
                 INS 
                 PP 
                 SRC 
               
               
                   
                 INS 
                 PP 
                 src family 
               
               
                   
                 INS 
                 PP 
                 TRH 
               
               
                   
                 INS 
                 PP 
                 TUB 
               
               
                   
                 INS 
                 PP 
                 VEGF 
               
               
                   
                 insulin receptor 
                 PP 
                 GAB1 
               
               
                   
                 insulin receptor 
                 PP 
                 SOS1 
               
               
                   
                 insulin receptor 
                 PP 
                 PRKCA 
               
               
                   
                 integrin 
                 PP 
                 FLT1 
               
               
                   
                 integrin 
                 PP 
                 PDGFB 
               
               
                   
                 integrin 
                 PP 
                 RHOA 
               
               
                   
                 interleukin IL12 
                 PP 
                 IFNG 
               
               
                   
                 interleukin IL12 
                 PP 
                 TNF 
               
               
                   
                 interleukin IL12 
                 PP 
                 IFNG 
               
               
                   
                 receptor 
               
               
                   
                 interleukin IL2 
                 PP 
                 BCL2 
               
               
                   
                 receptor 
               
               
                   
                 interleukin IL2 
                 PP 
                 IFNG 
               
               
                   
                 receptor 
               
               
                   
                 interleukin IL2 
                 PP 
                 PTK2B 
               
               
                   
                 receptor 
               
               
                   
                 IRF1 
                 PP 
                 STAT1 
               
               
                   
                 IRF7 
                 PP 
                 MAPK8 
               
               
                   
                 IRS1 
                 PP 
                 PTK2 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 48 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 ITK 
                 PP 
                 TGFB1 
               
               
                   
                 JAK1 
                 PP 
                 IFNG 
               
               
                   
                 JAK2 
                 PP 
                 EGFR 
               
               
                   
                 JAK2 
                 PP 
                 IGF1 
               
               
                   
                 JUN 
                 PP 
                 JUN 
               
               
                   
                 JUN 
                 PP 
                 PRKCE 
               
               
                   
                 JUN 
                 PP 
                 ABCB1 
               
               
                   
                 JUN 
                 PP 
                 ABL1 
               
               
                   
                 JUN 
                 PP 
                 AKT1 
               
               
                   
                 JUN 
                 PP 
                 ATF2 
               
               
                   
                 JUN 
                 PP 
                 ATF3 
               
               
                   
                 JUN 
                 PP 
                 CANK2A 
               
               
                   
                 JUN 
                 PP 
                 caspase 
               
               
                   
                 JUN 
                 PP 
                 CNTF 
               
               
                   
                 JUN 
                 PP 
                 EDN1 
               
               
                   
                 JUN 
                 PP 
                 EGFR 
               
               
                   
                 JUN 
                 PP 
                 FH1 
               
               
                   
                 JUN 
                 PP 
                 IL6 
               
               
                   
                 JUN 
                 PP 
                 IL8 
               
               
                   
                 JUN 
                 PP 
                 map kinase 
               
               
                   
                 JUN 
                 PP 
                 MAP2K4 
               
               
                   
                 JUN 
                 PP 
                 MAP3K1 
               
               
                   
                 JUN 
                 PP 
                 MAPK14 
               
               
                   
                 JUN 
                 PP 
                 MET 
               
               
                   
                 JUN 
                 PP 
                 MITF 
               
               
                   
                 JUN 
                 PP 
                 MAP9 
               
               
                   
                 JUN 
                 PP 
                 NFAT 
               
               
                   
                 JUN 
                 PP 
                 NFKB1 
               
               
                   
                 JUN 
                 PP 
                 Nuclear factor NF 
               
               
                   
                   
                   
                 kappa B 
               
               
                   
                 JUN 
                 PP 
                 ODC1 
               
               
                   
                 JUN 
                 PP 
                 PGE2 
               
               
                   
                 JUN 
                 PP 
                 platelet-derived 
               
               
                   
                   
                   
                 growth factor 
               
               
                   
                 JUN 
                 PP 
                 protein serine/ 
               
               
                   
                   
                   
                 threonine kinase 
               
               
                   
                 JUN 
                 PP 
                 protein tyrosine kinase 
               
               
                   
                 JUN 
                 PP 
                 RAF1 
               
               
                   
                 JUN 
                 PP 
                 replication factor C 
               
               
                   
                 JUN 
                 PP 
                 RIPK2 
               
               
                   
                 JUN 
                 PP 
                 RPS6K 
               
               
                   
                 JUN 
                 PP 
                 SP1 
               
               
                   
                 JUN 
                 PP 
                 SPP1 
               
               
                   
                 JUN 
                 PP 
                 TNF 
               
               
                   
                 JUN 
                 PP 
                 TNFRSF6 
               
               
                   
                 JUN 
                 PP 
                 tumor necrosis factor 
               
               
                   
                 JUN 
                 PP 
                 VEGF 
               
               
                   
                 JUNB 
                 PP 
                 FOSL1 
               
               
                   
                 JUND 
                 PP 
                 YAPK3 
               
               
                   
                 KDR 
                 PP 
                 IFNG 
               
               
                   
                 KDR 
                 PP 
                 PLOG1 
               
               
                   
                 KITLG 
                 PP 
                 HGF 
               
               
                   
                 KITLG 
                 PP 
                 IL1A 
               
               
                   
                 KITLG 
                 PP 
                 IL3 
               
               
                   
                 KITLG 
                 PP 
                 IL4 
               
               
                   
                 LC   
                 PP 
                 JUN 
               
               
                   
                 LDL 
                 PP 
                 TNF 
               
               
                   
                 LDLR 
                 PP 
                 APOE 
               
               
                   
                 LEF 
                 PP 
                 CCND1 
               
               
                   
                 LEP 
                 PP 
                 CCK 
               
               
                   
                 LEP 
                 PP 
                 EDN1 
               
               
                   
                 LEP 
                 PP 
                 IL16 
               
               
                   
                 LEP 
                 PP 
                 IL1F8 
               
               
                   
                 LEP 
                 PP 
                 IL6 
               
               
                   
                 LEP 
                 PP 
                 LIF 
               
               
                   
                 LEP 
                 PP 
                 MAPK8 
               
               
                   
                 LEP 
                 PP 
                 PRL 
               
               
                   
                 LIF 
                 PP 
                 CEBP8 
               
               
                   
                 LIF 
                 PP 
                 KITLG 
               
               
                   
                 LIF 
                 PP 
                 PRKCD 
               
               
                   
                 LIF 
                 PP 
                 STAT3 
               
               
                   
                 LIF 
                 PP 
                 TNF 
               
               
                   
                 LIP 
                 PP 
                 PTPN11 
               
               
                   
                 LPA 
                 PP 
                 EGF 
               
               
                   
                 LPA 
                 PP 
                 IGF1 
               
               
                   
                 LPA 
                 PP 
                 IL6 
               
               
                   
                 LPA 
                 PP 
                 RHOA 
               
               
                   
                 LPA 
                 PP 
                 SERPINE1 
               
               
                   
                 LPS 
                 PP 
                 MAPK1 
               
               
                   
                 LPS 
                 PP 
                 MAPK3 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 49 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 LRPAP1 
                 PP 
                 MAPK1 
               
               
                   
                 LTA 
                 PP 
                 TNF 
               
               
                   
                 LTB 
                 PP 
                 MAPK1 
               
               
                   
                 LTB 
                 PP 
                 TNF 
               
               
                   
                 LYN 
                 PP 
                 B-cell receptor 
               
               
                   
                 LYN 
                 PP 
                 IL5 
               
               
                   
                 LYN 
                 PP 
                 platelet-derived 
               
               
                   
                   
                   
                 growth factor 
               
               
                   
                 LYN 
                 PP 
                 protein tyrosine kinase 
               
               
                   
                 MAD 
                 PP 
                 TGFB1 
               
               
                   
                 map kinase 
                 PP 
                 EGR1 
               
               
                   
                 map kinase 
                 PP 
                 TNF 
               
               
                   
                 map kinase 
                 PP 
                 IFNG 
               
               
                   
                 MAP2K1 
                 PP 
                 IL2 
               
               
                   
                 MAP2K1 
                 PP 
                 IL6 
               
               
                   
                 MAP2K1 
                 PP 
                 JUN 
               
               
                   
                 MAP2K1 
                 PP 
                 PTK2 
               
               
                   
                 MAP2K6 
                 PP 
                 JUN 
               
               
                   
                 MAP2K6 
                 PP 
                 MAPK3 
               
               
                   
                 MAP2K6 
                 PP 
                 MAPK8 
               
               
                   
                 MAP3K1 
                 PP 
                 MAPK2K1 
               
               
                   
                 MAP3K1 
                 PP 
                 MAPK3 
               
               
                   
                 MAP3K1 
                 PP 
                 TP53 
               
               
                   
                 MAP3K11 
                 PP 
                 MAPK1 
               
               
                   
                 MAP3K5 
                 PP 
                 MAPK8 
               
               
                   
                 MAP3K8 
                 PP 
                 MAPK8 
               
               
                   
                 MAPK1 
                 PP 
                 ADAN17 
               
               
                   
                 MAPK1 
                 PP 
                 ADCY2 
               
               
                   
                 MAPK1 
                 PP 
                 ADP 
               
               
                   
                 MAPK1 
                 PP 
                 AGTR1 
               
               
                   
                 MAPK1 
                 PP 
                 ALON12 
               
               
                   
                 MAPK1 
                 PP 
                 CaS-kinase II 
               
               
                   
                 MAPK1 
                 PP 
                 DCL5 
               
               
                   
                 MAPK1 
                 PP 
                 CDKN1B 
               
               
                   
                 MAPK1 
                 PP 
                 CFLAR 
               
               
                   
                 MAPK1 
                 PP 
                 CKCL12 
               
               
                   
                 MAPK1 
                 PP 
                 ELK1 
               
               
                   
                 MAPK1 
                 PP 
                 FPR1 
               
               
                   
                 MAPK1 
                 PP 
                 GJA1 
               
               
                   
                 MAPK1 
                 PP 
                 GRB2 
               
               
                   
                 MAPK1 
                 PP 
                 MAP kinase 
               
               
                   
                 MAPK1 
                 PP 
                 MAPK9 
               
               
                   
                 MAPK1 
                 PP 
                 MP3 
               
               
                   
                 MAPK1 
                 PP 
                 MSK1 
               
               
                   
                 MAPK1 
                 PP 
                 NYDA receptor 
               
               
                   
                 MAPK1 
                 PP 
                 FDPK1 
               
               
                   
                 MAPK1 
                 PP 
                 PKG 
               
               
                   
                 MAPK1 
                 PP 
                 PPARA 
               
               
                   
                 MAPK1 
                 PP 
                 PRKCZ 
               
               
                   
                 MAPK1 
                 PP 
                 protein phosphatase 
               
               
                   
                 MAPK1 
                 PP 
                 PTK2B 
               
               
                   
                 MAPK1 
                 PP 
                 RPS6KA2 
               
               
                   
                 MAPK1 
                 PP 
                 RPS5KA4 
               
               
                   
                 MAPK1 
                 PP 
                 SSTR4 
               
               
                   
                 MAPK1 
                 PP 
                 TERF2IP 
               
               
                   
                 MAPK1 
                 PP 
                 TLR4 
               
               
                   
                 MAPK1 
                 PP 
                 TNFSF11 
               
               
                   
                 MAPK1 
                 PP 
                 tumor necrosis factor 
               
               
                   
                 MAPK14 
                 PP 
                 AGT 
               
               
                   
                 MAPK14 
                 PP 
                 CSF1 
               
               
                   
                 MAPK14 
                 PP 
                 EDN1 
               
               
                   
                 MAPK14 
                 PP 
                 ELA2 
               
               
                   
                 MAPK14 
                 PP 
                 TCAN1 
               
               
                   
                 MAPK14 
                 PP 
                 IL2 
               
               
                   
                 MAPK14 
                 PP 
                 K LG 
               
               
                   
                 MAPK14 
                 PP 
                 NGFB 
               
               
                   
                 MAPK14 
                 PP 
                 PDGFRA 
               
               
                   
                 MAPK14 
                 PP 
                 STAT1 
               
               
                   
                 MAPK14 
                 PP 
                 VEGF 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 50 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 MAPK3 
                 PP 
                 AGTR1 
               
               
                   
                 MAPK3 
                 PP 
                 CSF2 
               
               
                   
                 MAPK3 
                 PP 
                 EGR1 
               
               
                   
                 MAPK3 
                 PP 
                 EIF354 
               
               
                   
                 MAPK3 
                 PP 
                 glutamate receptor 
               
               
                   
                 MAPK3 
                 PP 
                 H2O2 
               
               
                   
                 MAPK3 
                 PP 
                 HTATIP 
               
               
                   
                 MAPK3 
                 PP 
                 IL6R 
               
               
                   
                 MAPK3 
                 PP 
                 IL8R8 
               
               
                   
                 MAPK3 
                 PP 
                 insulin receptor 
               
               
                   
                 MAPK3 
                 PP 
                 LRPAP1 
               
               
                   
                 MAPK3 
                 PP 
                 NYP3 
               
               
                   
                 MAPK3 
                 PP 
                 NPPA 
               
               
                   
                 MAPK3 
                 PP 
                 Nuclear factor NF 
               
               
                   
                   
                   
                 kappa 8 
               
               
                   
                 MAPK3 
                 PP 
                 PDEGH 
               
               
                   
                 MAPK3 
                 PP 
                 PKA 
               
               
                   
                 MAPK3 
                 PP 
                 PLA2GIB 
               
               
                   
                 MAPK3 
                 PP 
                 prostaglandin 
               
               
                   
                 MAPK3 
                 PP 
                 protein serine/ 
               
               
                   
                   
                   
                 threonine kinase 
               
               
                   
                 MAPK3 
                 PP 
                 RAF1 
               
               
                   
                 MAPK3 
                 PP 
                 RAPGEF1 
               
               
                   
                 MAPK3 
                 PP 
                 RASGRP1 
               
               
                   
                 MAPK3 
                 PP 
                 receptor tyrosine kinase 
               
               
                   
                 MAPK3 
                 PP 
                 RPS6KB1 
               
               
                   
                 MAPK3 
                 PP 
                 TNF 
               
               
                   
                 MAPK3 
                 PP 
                 TNFRSF5 
               
               
                   
                 MAPK3 
                 PP 
                 transcription factor 
               
               
                   
                 MAPK3 
                 PP 
                 tranmembrane receptor 
               
               
                   
                   
                   
                 protein tyrosine kinase 
               
               
                   
                 MAPK3 
                 PP 
                 VEGF 
               
               
                   
                 MAPK8 
                 PP 
                 APP 
               
               
                   
                 MAPK8 
                 PP 
                 B-cell receptor 
               
               
                   
                 MAPK8 
                 PP 
                 CASP3 
               
               
                   
                 MAPK8 
                 PP 
                 CASP8 
               
               
                   
                 MAPK8 
                 PP 
                 CASP9 
               
               
                   
                 MAPK8 
                 PP 
                 CCL5 
               
               
                   
                 MAPK8 
                 PP 
                 CYCS 
               
               
                   
                 MAPK8 
                 PP 
                 DUSP22 
               
               
                   
                 MAPK8 
                 PP 
                 EGFR 
               
               
                   
                 MAPK8 
                 PP 
                 EPHA4 
               
               
                   
                 MAPK8 
                 PP 
                 EPX 
               
               
                   
                 MAPK8 
                 PP 
                 F2 
               
               
                   
                 MAPK8 
                 PP 
                 FADD 
               
               
                   
                 MAPK8 
                 PP 
                 HYOX1 
               
               
                   
                 MAPK8 
                 PP 
                 HTATIP 
               
               
                   
                 MAPK8 
                 PP 
                 IL1F8 
               
               
                   
                 MAPK8 
                 PP 
                 LTB 
               
               
                   
                 MAPK8 
                 PP 
                 nap kinase 
               
               
                   
                 MAPK8 
                 PP 
                 MAP2K7 
               
               
                   
                 MAPK8 
                 PP 
                 MAP3K1 
               
               
                   
                 MAPK8 
                 PP 
                 MAP3K11 
               
               
                   
                 MAPK8 
                 PP 
                 MAP3K2 
               
               
                   
                 MAPK8 
                 PP 
                 MAP3K3 
               
               
                   
                 MAPK8 
                 PP 
                 MAP3K4 
               
               
                   
                 MAPK8 
                 PP 
                 NEDD9 
               
               
                   
                 MAPK8 
                 PP 
                 PGE2 
               
               
                   
                 MAPK8 
                 PP 
                 PIAS1 
               
               
                   
                 MAPK8 
                 PP 
                 platelet-derived 
               
               
                   
                   
                   
                 growth factor 
               
               
                   
                 MAPK8 
                 PP 
                 PTGS2 
               
               
                   
                 MAPK8 
                 PP 
                 PTK23 
               
               
                   
                 MAPK8 
                 PP 
                 RAS small monomeric 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                 MAPK8 
                 PP 
                 replication factor C 
               
               
                   
                 MAPK8 
                 PP 
                 RHOB 
               
               
                   
                 MAPK8 
                 PP 
                 src family 
               
               
                   
                 MAPK8 
                 PP 
                 telomerase 
               
               
                   
                 MAPK8 
                 PP 
                 transcription factor 
               
               
                   
                 MAPK8 
                 PP 
                 VEGF 
               
               
                   
                 MBP 
                 PP 
                 INS 
               
               
                   
                 MBP 
                 PP 
                 TGFB1 
               
               
                   
                 MCL1 
                 PP 
                 EGFR 
               
               
                   
                 MDH2 
                 PP 
                 ligase 
               
               
                   
                 MDK2 
                 PP 
                 RAS small monomeric 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 51 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 MDP 
                 PP 
                 F2R 
               
               
                   
                 MDP 
                 PP 
                 IFKG 
               
               
                   
                 MDP 
                 PP 
                 IL6 
               
               
                   
                 MDP 
                 PP 
                 TNF 
               
               
                   
                 MDP 
                 PP 
                 TNF 
               
               
                   
                 MHP1 
                 PP 
                 IL6 
               
               
                   
                 MHP2 
                 PP 
                 BS6 
               
               
                   
                 MHP2 
                 PP 
                 EPHA1 
               
               
                   
                 MHP2 
                 PP 
                 FGF2 
               
               
                   
                 MHP2 
                 PP 
                 IL1F8 
               
               
                   
                 MHP2 
                 PP 
                 NKP13 
               
               
                   
                 MHP2 
                 PP 
                 NKP14 
               
               
                   
                 MHP2 
                 PP 
                 NKP9 
               
               
                   
                 MHP2 
                 PP 
                 VEGF 
               
               
                   
                 MHP7 
                 PP 
                 EGFR 
               
               
                   
                 MHP9 
                 PP 
                 EGF 
               
               
                   
                 MHP9 
                 PP 
                 IL8 
               
               
                   
                 MHP9 
                 PP 
                 TGF31 
               
               
                   
                 MHP9 
                 PP 
                 TNF 
               
               
                   
                 MHP9 
                 PP 
                 VEGF 
               
               
                   
                 MPO 
                 PP 
                 CSF3 
               
               
                   
                 MYC 
                 PP 
                 PRKCE 
               
               
                   
                 MYC 
                 PP 
                 RAF1 
               
               
                   
                 MYC 
                 PP 
                 TNF 
               
               
                   
                 MYC 
                 PP 
                 TNFSF6 
               
               
                   
                 NBS1 
                 PP 
                 TP53 
               
               
                   
                 NF1 
                 PP 
                 GTPase 
               
               
                   
                 NFKB1 
                 PP 
                 CCHD1 
               
               
                   
                 NGFB 
                 PP 
                 BONF 
               
               
                   
                 NGFB 
                 PP 
                 CREB1 
               
               
                   
                 NGFB 
                 PP 
                 FOS 
               
               
                   
                 NGFB 
                 PP 
                 GAB1 
               
               
                   
                 NGFB 
                 PP 
                 GSK3B 
               
               
                   
                 NGFB 
                 PP 
                 IL3 
               
               
                   
                 NGFB 
                 PP 
                 IL6 
               
               
                   
                 NGFB 
                 PP 
                 NAPK1 
               
               
                   
                 NGFB 
                 PP 
                 NAPK3 
               
               
                   
                 NGFB 
                 PP 
                 PRKCE 
               
               
                   
                 NGFB 
                 PP 
                 PTGS2 
               
               
                   
                 NGFB 
                 PP 
                 TAC1 
               
               
                   
                 NGFR 
                 PP 
                 NAPK3 
               
               
                   
                 NGFR 
                 PP 
                 TP53 
               
               
                   
                 nitric oxide synthase 
                 PP 
                 IFNG 
               
               
                   
                 NO 
                 PP 
                 NAPK1 
               
               
                   
                 NOS2A 
                 PP 
                 JAK2 
               
               
                   
                 NOS2A 
                 PP 
                 NAPK3 
               
               
                   
                 NOS3 
                 PP 
                 AKT1 
               
               
                   
                 NPPA 
                 PP 
                 PRKCA 
               
               
                   
                 NR1T2 
                 PP 
                 CYP3A4 
               
               
                   
                 NRP1 
                 PP 
                 EGFR 
               
               
                   
                 NTRK1 
                 PP 
                 NAPK3 
               
               
                   
                 NTRK3 
                 PP 
                 NAPK3 
               
               
                   
                 Nuclear factor NF 
                 PP 
                 CKCL1 
               
               
                   
                 kappa B 
               
               
                   
                 ODC1 
                 PP 
                 RHO4 
               
               
                   
                 OSH 
                 PP 
                 NAPK3 
               
               
                   
                 OXT 
                 PP 
                 PTES2 
               
               
                   
                 P2Y receptor 
                 PP 
                 NAPK3 
               
               
                   
                 PAK1 
                 PP 
                 TNF 
               
               
                   
                 PAKR 
                 PP 
                 F2R 
               
               
                   
                 PAKR 
                 PP 
                 TNF 
               
               
                   
                 PC4 
                 PP 
                 PSNO9 
               
               
                   
                 PCNA 
                 PP 
                 TP53 
               
               
                   
                 PDGFB 
                 PP 
                 platelet-derived 
               
               
                   
                   
                   
                 growth factor 
               
               
                   
                 PDPK1 
                 PP 
                 RAS small monomeric 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                 PDPK1 
                 PP 
                 Rho small monomeric 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                 peptide receptor, 
                 PP 
                 RHOA 
               
               
                   
                 G-protein coupled 
               
               
                   
                 PGE1 
                 PP 
                 YAPK8 
               
               
                   
                 PGE2 
                 PP 
                 CEBPB 
               
               
                   
                 PGE2 
                 PP 
                 ILG 
               
               
                   
                 Phosphatidylinositol 
                 PP 
                 E F4EBP1 
               
               
                   
                 3-kinase 
               
               
                   
                 Phosphatidylinositol 
                 PP 
                 PLA2G13 
               
               
                   
                 3-kinase 
               
               
                   
                 Phosphatidylinositol 
                 PP 
                 RAC1 
               
               
                   
                 3-kinase 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 52 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 phospholipase 
                 PP 
                 TNF 
               
               
                   
                 phospholipase C 
                 PP 
                 PLCG1 
               
               
                   
                 PKA 
                 PP 
                 TGFB1 
               
               
                   
                 PKC 
                 PP 
                 EGR1 
               
               
                   
                 PKC 
                 PP 
                 ETS1 
               
               
                   
                 PKC 
                 PP 
                 F2R 
               
               
                   
                 PKC 
                 PP 
                 PRKCABP 
               
               
                   
                 PKC 
                 PP 
                 RHOA 
               
               
                   
                 PLA2G1B 
                 PP 
                 IL2 
               
               
                   
                 PLA2G1B 
                 PP 
                 IL6 
               
               
                   
                 PLA2G1B 
                 PP 
                 NAPK1 
               
               
                   
                 PLA2G1B 
                 PP 
                 NAPK14 
               
               
                   
                 PLA2G1B 
                 PP 
                 PTGS2 
               
               
                   
                 platelet-derived 
                 PP 
                 AKT1 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PP 
                 EIF4E 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PP 
                 LPA 
               
               
                   
                 growth factor 
               
               
                   
                 platelet-derived 
                 PP 
                 SERPIKE1 
               
               
                   
                 growth factor 
               
               
                   
                 PLAUR 
                 PP 
                 integrin 
               
               
                   
                 PLAUR 
                 PP 
                 PLAU 
               
               
                   
                 PLAUR 
                 PP 
                 PLG 
               
               
                   
                 PLAUR 
                 PP 
                 thronbin 
               
               
                   
                 PLCG1 
                 PP 
                 choline phosphatase 
               
               
                   
                 PLCG1 
                 PP 
                 fibroblast growth factor 
               
               
                   
                 PLCG1 
                 PP 
                 growth factor receptor 
               
               
                   
                 PLCG1 
                 PP 
                 HGF 
               
               
                   
                 PLCG1 
                 PP 
                 inositol phosphate 
               
               
                   
                 PLCG1 
                 PP 
                 inositol phosphates 
               
               
                   
                 PLCG1 
                 PP 
                 INS 
               
               
                   
                 PLCG1 
                 PP 
                 Phosphatidylinositol 
               
               
                   
                   
                   
                 3-kinase 
               
               
                   
                 PLCG1 
                 PP 
                 protein tyrosine kinase 
               
               
                   
                 PLCG1 
                 PP 
                 src family 
               
               
                   
                 PLCG1 
                 PP 
                 T-cell receptor 
               
               
                   
                   
                   
                 T3 complex 
               
               
                   
                 PLCG1 
                 PP 
                 TERF2TP 
               
               
                   
                 PLG 
                 PP 
                 fibrin(ogen) 
               
               
                   
                 PNA 
                 PP 
                 TGFB1 
               
               
                   
                 POYC 
                 PP 
                 CXCL1 
               
               
                   
                 POYC 
                 PP 
                 FN1 
               
               
                   
                 POYC 
                 PP 
                 FOS 
               
               
                   
                 POYC 
                 PP 
                 GH1 
               
               
                   
                 POYC 
                 PP 
                 IL6 
               
               
                   
                 PPARA 
                 PP 
                 CEBPG 
               
               
                   
                 PRKCA 
                 PP 
                 INS 
               
               
                   
                 PRKCA 
                 PP 
                 RAF1 
               
               
                   
                 PRKCD 
                 PP 
                   FNA1 
               
               
                   
                 PRKCD 
                 PP 
                 YAPK14 
               
               
                   
                 PRKCD 
                 PP 
                 RAF1 
               
               
                   
                 PRKCD 
                 PP 
                 TGF31 
               
               
                   
                 PRKCE 
                 PP 
                 EGF 
               
               
                   
                 PRKCE 
                 PP 
                 Nuclear factor NF 
               
               
                   
                   
                   
                 kappa B 
               
               
                   
                 PRKCE 
                 PP 
                 PKC 
               
               
                   
                 PRKCE 
                 PP 
                 PRKCZ 
               
               
                   
                 PRKCZ 
                 PP 
                 IL1 
               
               
                   
                 PRKCZ 
                 PP 
                 map kinase 
               
               
                   
                 PRKCZ 
                 PP 
                 Nuclear factor NF 
               
               
                   
                   
                   
                 kappa B 
               
               
                   
                 PRKCZ 
                 PP 
                 Phosphatidylinositol 
               
               
                   
                   
                   
                 3-kinase 
               
               
                   
                 PRKCZ 
                 PP 
                 RPS6K 
               
               
                   
                 PRL 
                 PP 
                 IL18 
               
               
                   
                 PRL 
                 PP 
                 INS 
               
               
                   
                 PRL 
                 PP 
                 YAPK1 
               
               
                   
                 PRL 
                 PP 
                 ODC1 
               
               
                   
                 PRL 
                 PP 
                 STAT1 
               
               
                   
                 PRL 
                 PP 
                 TAC1 
               
               
                   
                 PROCR 
                 PP 
                 THBD 
               
               
                   
                 progesterone 
                 PP 
                 NAPK1 
               
               
                   
                 PROS1 
                 PP 
                 EL6R 
               
               
                   
                 protein phosphatase 
                 PP 
                 YAPK8 
               
               
                   
                 protein serine/ 
                 PP 
                 NAPK1 
               
               
                   
                 threonine kinase 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 53 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 protein tyrosine 
                 PP 
                 GAB1 
               
               
                   
                 kinase 
               
               
                   
                 protein tyrosine 
                 PP 
                 NAPK3 
               
               
                   
                 kinase 
               
               
                   
                 protein tyrosine 
                 PP 
                 RHOA 
               
               
                   
                 kinase 
               
               
                   
                 protein tyrosine 
                 PP 
                 TGFB1 
               
               
                   
                 kinase 
               
               
                   
                 PSYD9 
                 PP 
                 COKN1A 
               
               
                   
                 PTEN 
                 PP 
                 CCND3 
               
               
                   
                 PTGIS 
                 PP 
                 ADCY2 
               
               
                   
                 PTGIS 
                 PP 
                 thromboxane A2 
               
               
                   
                 PTGIS 
                 PP 
                 VE F 
               
               
                   
                 PTGS2 
                 PP 
                 EGFR 
               
               
                   
                 PTGS2 
                 PP 
                 HSPA4 
               
               
                   
                 PTGS2 
                 PP 
                 YAP2K1 
               
               
                   
                 PTGS2 
                 PP 
                 REN 
               
               
                   
                 PTH 
                 PP 
                 voltage-gated calcium 
               
               
                   
                   
                   
                 channel 
               
               
                   
                 PTHLH 
                 PP 
                 IL6 
               
               
                   
                 PTK2 
                 PP 
                 ARHGEF12 
               
               
                   
                 PTK2 
                 PP 
                 GRB2 
               
               
                   
                 PTK2B 
                 PP 
                 AGT 
               
               
                   
                 PTK2B 
                 PP 
                 COKN1A 
               
               
                   
                 PTK2B 
                 PP 
                 RPSGKB1 
               
               
                   
                 PTK2B 
                 PP 
                 SYK 
               
               
                   
                 PTPH11 
                 PP 
                 IL6 
               
               
                   
                 RAC1 
                 PP 
                 ARF1 
               
               
                   
                 RAC1 
                 PP 
                 ARF6 
               
               
                   
                 RAC1 
                 PP 
                 CO44 
               
               
                   
                 RAC1 
                 PP 
                 EGFR 
               
               
                   
                 RAC1 
                 PP 
                 FGF2 
               
               
                   
                 RAC1 
                 PP 
                 GDP 
               
               
                   
                 RAC1 
                 PP 
                 IL1 
               
               
                   
                 RAC1 
                 PP 
                 KITLG 
               
               
                   
                 RAC1 
                 PP 
                 RASGRP1 
               
               
                   
                 RAC1 
                 PP 
                 TNFSF6 
               
               
                   
                 RAC1 
                 PP 
                 WASF2 
               
               
                   
                 RAF1 
                 PP 
                 COKN1A 
               
               
                   
                 RAF1 
                 PP 
                 EGFR 
               
               
                   
                 RAF1 
                 PP 
                 ELK1 
               
               
                   
                 RAF1 
                 PP 
                 HSPCA 
               
               
                   
                 RAF1 
                 PP 
                 HAP K1 
               
               
                   
                 RAF1 
                 PP 
                 SRC 
               
               
                   
                 RAF1 
                 PP 
                 TGFB1 
               
               
                   
                 RAPGEF1 
                 PP 
                 NAPK1 
               
               
                   
                 RARA 
                 PP 
                   L3 
               
               
                   
                 RARA 
                 PP 
                 TGFB1 
               
               
                   
                 RAS small monomeric 
                 PP 
                 CDKN1A 
               
               
                   
                 GTPase 
               
               
                   
                 RAS small monomeric 
                 PP 
                 EGR1 
               
               
                   
                 GTPase 
               
               
                   
                 RAS small monomeric 
                 PP 
                 NAPK3 
               
               
                   
                 GTPase 
               
               
                   
                 RASGRP1 
                 PP 
                 NAPK1 
               
               
                   
                 RB1 
                 PP 
                 HGF 
               
               
                   
                 RB1 
                 PP 
                 NYC 
               
               
                   
                 RBL1 
                 PP 
                 E2F4 
               
               
                   
                 RELA 
                 PP 
                 TNFRSF6 
               
               
                   
                 replication factor C 
                 PP 
                 NAPK1 
               
               
                   
                 Rho kinase 
                 PP 
                 RHOA 
               
               
                   
                 RHOA 
                 PP 
                 Glass A G-protein 
               
               
                   
                   
                   
                 coupled receptor 
               
               
                   
                 RHOA 
                 PP 
                 EGR1 
               
               
                   
                 RHOA 
                 PP 
                 GNA12 
               
               
                   
                 RHOA 
                 PP 
                 GNA13 
               
               
                   
                 RHOA 
                 PP 
                 NCF2L 
               
               
                   
                 RHOA 
                 PP 
                 PPPIR12A 
               
               
                   
                 RHOC 
                 PP 
                 NAPK3 
               
               
                   
                 RHOC 
                 PP 
                 RAC1 
               
               
                   
                 ROCK1 
                 PP 
                 RHOA 
               
               
                   
                 RPS6K 
                 PP 
                 COKN2A 
               
               
                   
                 RPS6K 
                 PP 
                 ELK1 
               
               
                   
                 RPS6K 
                 PP 
                 ERBB2 
               
               
                   
                 RPS6K 
                 PP 
                 NAPK3 
               
               
                   
                 RPS6K 
                 PP 
                 src family 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 54 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 RPS5KA2 
                 PP 
                 HAPK3 
               
               
                   
                 RPS6KB1 
                 PP 
                 CSF2 
               
               
                   
                 RPS6KB1 
                 PP 
                   GF1 
               
               
                   
                 RPS6KB1 
                 PP 
                   AK 
               
               
                   
                 RP56KB1 
                 PP 
                 SRC 
               
               
                   
                 RRAS 
                 PP 
                 BCAR1 
               
               
                   
                 RXRA 
                 PP 
                 TNF 
               
               
                   
                 SAA2 
                 PP 
                 TNF 
               
               
                   
                 SAP kinase 
                 PP 
                   N 
               
               
                   
                 SAP kinase 
                 PP 
                 NAPK1 
               
               
                   
                 SCYL1 
                 PP 
                 TNF 
               
               
                   
                 SERPINE1 
                 PP 
                 F3 
               
               
                   
                 SERPINE1 
                 PP 
                 IL6 
               
               
                   
                 SFTPA1 
                 PP 
                 IL6 
               
               
                   
                 SHC1 
                 PP 
                 IL6 
               
               
                   
                 SHC1 
                 PP 
                   S 
               
               
                   
                 SHC1 
                 PP 
                 NGFB 
               
               
                   
                 SHC1 
                 PP 
                 PLDG1 
               
               
                   
                 SIAH1 
                 PP 
                 CDKN1A 
               
               
                   
                 signal peptide 
                 PP 
                 CRK 
               
               
                   
                 peptidase 
               
               
                   
                 small monomeric 
                 PP 
                 HAPK3 
               
               
                   
                 GTPase 
               
               
                   
                 SOSI 
                 PP 
                 HAPK8 
               
               
                   
                 SPI 
                 PP 
                 SERPINE1 
               
               
                   
                 SP B 
                 PP 
                 IFR6 
               
               
                   
                 SRC 
                 PP 
                 CBL 
               
               
                   
                 SRC 
                 PP 
                 CCND1 
               
               
                   
                 SRC 
                 PP 
                 CTGF 
               
               
                   
                 SRC 
                 PP 
                 ERBB2 
               
               
                   
                 SRC 
                 PP 
                 HIF1A 
               
               
                   
                 SRC 
                 PP 
                 ICAN1 
               
               
                   
                 SRC 
                 PP 
                 NYG 
               
               
                   
                 SRC 
                 PP 
                 NPPA 
               
               
                   
                 SRC 
                 PP 
                 PTK2B 
               
               
                   
                 SRC 
                 PP 
                 SHC1 
               
               
                   
                 src family 
                 PP 
                 YAPK1 
               
               
                   
                 src family 
                 PP 
                 YAPK3 
               
               
                   
                 src family 
                 PP 
                 PTK2 
               
               
                   
                 src family 
                 PP 
                 PTK2B 
               
               
                   
                 SRF 
                 PP 
                 ELK1 
               
               
                   
                 STAT1 
                 PP 
                 CSF1 
               
               
                   
                 STAT1 
                 PP 
                 EGF 
               
               
                   
                 STAT1 
                 PP 
                 IFNG 
               
               
                   
                 STAT1 
                 PP 
                 IL2 
               
               
                   
                 STAT1 
                 PP 
                 YAPK1 
               
               
                   
                 STAT3 
                 PP 
                 HGF 
               
               
                   
                 STAT3 
                 PP 
                 YAPK14 
               
               
                   
                 STAT3 
                 PP 
                 STAT5A 
               
               
                   
                 STAT5A 
                 PP 
                 BCL2L1 
               
               
                   
                 STAT5A 
                 PP 
                 IL5 
               
               
                   
                 STAT5A 
                 PP 
                 IL5 
               
               
                   
                 STAT6 
                 PP 
                 IL4 
               
               
                   
                 STAT6 
                 PP 
                 IL4R 
               
               
                   
                 SYK 
                 PP 
                 FegammaRI 
               
               
                   
                 SYK 
                 PP 
                 LYN 
               
               
                   
                 T cell transition 
                 PP 
                 JUN 
               
               
                   
                 factor NFATC 
               
               
                   
                 TAC1 
                 PP 
                 FOS 
               
               
                   
                 TAF1 
                 PP 
                 CCND1 
               
               
                   
                 TAP1 
                 PP 
                 IFNG 
               
               
                   
                 T-cell receptor 
                 PP 
                 IFNG 
               
               
                   
                 T3 complex 
               
               
                   
                 T-cell receptor 
                 PP 
                 HAPK1 
               
               
                   
                 T3 complex 
               
               
                   
                 TFIID 
                 PP 
                 TP53 
               
               
                   
                 TGFA 
                 PP 
                 EGFR 
               
               
                   
                 TGFA 
                 PP 
                 FNI 
               
               
                   
                 TGFA 
                 PP 
                 HGF 
               
               
                   
                 TGFA 
                 PP 
                   GF1 
               
               
                   
                 TGFA 
                 PP 
                 IL1B 
               
               
                   
                 TGFA 
                 PP 
                 IL6 
               
               
                   
                 TGFA 
                 PP 
                 RAF1 
               
               
                   
                 TGFA 
                 PP 
                 TP53 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 55 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 TGFB1 
                 PP 
                 ADP 
               
               
                   
                 TGFB1 
                 PP 
                 alphaVbeta6 
               
               
                   
                 TGFB1 
                 PP 
                 CRP 
               
               
                   
                 TGFB1 
                 PP 
                 EDN1 
               
               
                   
                 TGFB1 
                 PP 
                 HIF1A 
               
               
                   
                 TGFB1 
                 PP 
                 IER2 
               
               
                   
                 TGFB1 
                 PP 
                 ILIR1 
               
               
                   
                 TGFB1 
                 PP 
                 IL8 
               
               
                   
                 TGFB1 
                 PP 
                 ITGAE 
               
               
                   
                 TGFB1 
                 PP 
                 LCP1 
               
               
                   
                 TGFB1 
                 PP 
                 LTBP1 
               
               
                   
                 TGFB1 
                 PP 
                 N F 
               
               
                   
                 TGFB1 
                 PP 
                 NYB13 
               
               
                   
                 TGFB1 
                 PP 
                 NYP14 
               
               
                   
                 TGFB1 
                 PP 
                 HYB 
               
               
                   
                 TGFB1 
                 PP 
                 HGFB 
               
               
                   
                 TGFB1 
                 PP 
                 PDGFA 
               
               
                   
                 TGFB1 
                 PP 
                 PDGFB 
               
               
                   
                 TGFB1 
                 PP 
                 PTAS3 
               
               
                   
                 TGFB1 
                 PP 
                 PKC 
               
               
                   
                 TGFB1 
                 PP 
                 protein-glutamine gamma- 
               
               
                   
                   
                   
                 glutanyltransferase 
               
               
                   
                 TGFB1 
                 PP 
                 PTH 
               
               
                   
                 TGFB1 
                 PP 
                 RHF7 
               
               
                   
                 TGFB1 
                 PP 
                 SPARC 
               
               
                   
                 TGFB1 
                 PP 
                 TFE3 
               
               
                   
                 TGFB1 
                 PP 
                 TGFB3 
               
               
                   
                 TGFB1 
                 PP 
                 TIEG 
               
               
                   
                 TGFB1 
                 PP 
                 TIEG2 
               
               
                   
                 TGFB1 
                 PP 
                 vitronectin receptor 
               
               
                   
                   
                   
                 (integrin) 
               
               
                   
                 TGFB1 
                 PP 
                 VTN 
               
               
                   
                 TGFB2 
                 PP 
                 TGFB1 
               
               
                   
                 TGFbetaR 
                 PP 
                 TGFB1 
               
               
                   
                 THPO 
                 PP 
                 IL6 
               
               
                   
                 thrombin 
                 PP 
                 PLCG1 
               
               
                   
                 TLR2 
                 PP 
                 IL6 
               
               
                   
                 TNF 
                 PP 
                 Achronobacter iophagus 
               
               
                   
                   
                   
                 collagenase 
               
               
                   
                 TNF 
                 PP 
                 AGTR1 
               
               
                   
                 TNF 
                 PP 
                 ANGPT2 
               
               
                   
                 TNF 
                 PP 
                 B2K 
               
               
                   
                 TNF 
                 PP 
                 CADPS 
               
               
                   
                 TNF 
                 PP 
                 calpain 
               
               
                   
                 TNF 
                 PP 
                 CCLI1 
               
               
                   
                 TNF 
                 PP 
                 CD14 
               
               
                   
                 TNF 
                 PP 
                 CD69 
               
               
                   
                 TNF 
                 PP 
                 CEACAV5 
               
               
                   
                 TNF 
                 PP 
                 CRADD 
               
               
                   
                 TNF 
                 PP 
                 CSF1 
               
               
                   
                 TNF 
                 PP 
                 ECE1 
               
               
                   
                 TNF 
                 PP 
                 EDN1 
               
               
                   
                 TNF 
                 PP 
                 endothelin 
               
               
                   
                 TNF 
                 PP 
                 EP300 
               
               
                   
                 TNF 
                 PP 
                 FADD 
               
               
                   
                 TNF 
                 PP 
                 FCER2 
               
               
                   
                 TNF 
                 PP 
                 FN1 
               
               
                   
                 TNF 
                 PP 
                 FS 1 
               
               
                   
                 TNF 
                 PP 
                 HTATIP 
               
               
                   
                 TNF 
                 PP 
                 IL1 
               
               
                   
                 TNF 
                 PP 
                 IL12B 
               
               
                   
                 TNF 
                 PP 
                 IL15 
               
               
                   
                 TNF 
                 PP 
                 IL18 
               
               
                   
                 TNF 
                 PP 
                 IL1A 
               
               
                   
                 TNF 
                 PP 
                 IL1B 
               
               
                   
                 TNF 
                 PP 
                 IL1F8 
               
               
                   
                 TNF 
                 PP 
                 IL2 
               
               
                   
                 TNF 
                 PP 
                 IL2RB 
               
               
                   
                 TNF 
                 PP 
                 IL7 
               
               
                   
                 TNF 
                 PP 
                 IL8 
               
               
                   
                 TNF 
                 PP 
                 integrin 
               
               
                   
                 TNF 
                 PP 
                 interleukin-I receptor 
               
               
                   
                   
                   
                 ligand 
               
               
                   
                 TNF 
                 PP 
                 ITGB2 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 56 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 TNF 
                 PP 
                 ITIH4 
               
               
                   
                 TNF 
                 PP 
                 JNK 
               
               
                   
                 TNF 
                 PP 
                 JUND 
               
               
                   
                 TNF 
                 PP 
                 LBP 
               
               
                   
                 TNF 
                 PP 
                 LPS 
               
               
                   
                 TNF 
                 PP 
                 NADCAK1 
               
               
                   
                 TNF 
                 PP 
                 NAPK8 
               
               
                   
                 TNF 
                 PP 
                 NAPKAPK2 
               
               
                   
                 TNF 
                 PP 
                 matrix petalloproteinase 
               
               
                   
                 TNF 
                 PP 
                 NDDC 
               
               
                   
                 TNF 
                 PP 
                 NHP14 
               
               
                   
                 TNF 
                 PP 
                 NYLK 
               
               
                   
                 TNF 
                 PP 
                 nadph oxidase 
               
               
                   
                 TNF 
                 PP 
                 NDUFA1 
               
               
                   
                 TNF 
                 PP 
                 NFKB1 
               
               
                   
                 TNF 
                 PP 
                 NGF8 
               
               
                   
                 TNF 
                 PP 
                 NDS2A 
               
               
                   
                 TNF 
                 PP 
                 PARP1 
               
               
                   
                 TNF 
                 PP 
                 PGF2 alpha 
               
               
                   
                 TNF 
                 PP 
                 PLA2G10 
               
               
                   
                 TNF 
                 PP 
                 PLA2G1B 
               
               
                   
                 TNF 
                 PP 
                 PLAU 
               
               
                   
                 TNF 
                 PP 
                 PRKCE 
               
               
                   
                 TNF 
                 PP 
                 PRKCH 
               
               
                   
                 TNF 
                 PP 
                 PRKCZ 
               
               
                   
                 TNF 
                 PP 
                 prostaglandin- 
               
               
                   
                   
                   
                 endoperoxide synthase 
               
               
                   
                 TNF 
                 PP 
                 protein serine/ 
               
               
                   
                   
                   
                 threonine kinase 
               
               
                   
                 TNF 
                 PP 
                 protein lyrosine kinase 
               
               
                   
                 TNF 
                 PP 
                 PTK28 
               
               
                   
                 TNF 
                 PP 
                 RAF1 
               
               
                   
                 TNF 
                 PP 
                 RAS small monomeric 
               
               
                   
                   
                   
                 GTPase 
               
               
                   
                 TNF 
                 PP 
                 replication factor C 
               
               
                   
                 TNF 
                 PP 
                 RIPK1 
               
               
                   
                 TNF 
                 PP 
                 RPSGK 
               
               
                   
                 TNF 
                 PP 
                 T cell transcription 
               
               
                   
                   
                   
                 factor NFATC 
               
               
                   
                 TNF 
                 PP 
                 TACR1 
               
               
                   
                 TNF 
                 PP 
                 TGFA 
               
               
                   
                 TNF 
                 PP 
                 TNFRSF9 
               
               
                   
                 TNF 
                 PP 
                 TNFSF5 
               
               
                   
                 TNF 
                 PP 
                 TND1 
               
               
                   
                 TNF 
                 PP 
                 TP53 
               
               
                   
                 TNF 
                 PP 
                 VLDL 
               
               
                   
                 TNF 
                 PP 
                 VTN 
               
               
                   
                 TNFRSF1A 
                 PP 
                 VAPK3 
               
               
                   
                 TNFRSF1A 
                 PP 
                 VAPK8 
               
               
                   
                 TNFRSF5 
                 PP 
                 CCL5 
               
               
                   
                 TNFRSF5 
                 PP 
                 IFNG 
               
               
                   
                 TNFRSF5 
                 PP 
                 JUN 
               
               
                   
                 TNFRSF6 
                 PP 
                 CASP3 
               
               
                   
                 TNFRSF6 
                 PP 
                 CD4 
               
               
                   
                 TNFRSF6 
                 PP 
                 CYCS 
               
               
                   
                 TNFRSF6 
                 PP 
                 PARP1 
               
               
                   
                 TNFSF10 
                 PP 
                 TP53 
               
               
                   
                 TNFSF5 
                 PP 
                 CD40 receptor 
               
               
                   
                 TNFSF5 
                 PP 
                 IFNG 
               
               
                   
                 TNFSF6 
                 PP 
                 CD4 
               
               
                   
                 TNFSF6 
                 PP 
                 CYCS 
               
               
                   
                 TNFSF6 
                 PP 
                 JUN 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 57 
               
               
                   
                   
               
               
                   
                   
               
               
                   
                 Protein A 
                   
                 Protein B 
               
               
                   
                   
               
             
            
               
                   
                 TP53 
                 PP 
                 ABC81 
               
               
                   
                 TP53 
                 PP 
                 AGT 
               
               
                   
                 TP53 
                 PP 
                 AXTN1 
               
               
                   
                 TP53 
                 PP 
                 CASP3 
               
               
                   
                 TP53 
                 PP 
                 CAV1 
               
               
                   
                 TP53 
                 PP 
                 CCNG1 
               
               
                   
                 TP53 
                 PP 
                 CDKN1A 
               
               
                   
                 TP53 
                 PP 
                 EGFR 
               
               
                   
                 TP53 
                 PP 
                 FNL2 
               
               
                   
                 TP53 
                 PP 
                 GADD45A 
               
               
                   
                 TP53 
                 PP 
                 HES1 
               
               
                   
                 TP53 
                 PP 
                 HGF 
               
               
                   
                 TP53 
                 PP 
                 HRAS 
               
               
                   
                 TP53 
                 PP 
                 NAPK8 
               
               
                   
                 TP53 
                 PP 
                 NSH2 
               
               
                   
                 TP53 
                 PP 
                 progesterone 
               
               
                   
                 TP53 
                 PP 
                 PTEN 
               
               
                   
                 TP53 
                 PP 
                 RACI 
               
               
                   
                 TP53 
                 PP 
                 SLC12A9 
               
               
                   
                 TP53 
                 PP 
                 SUH01 
               
               
                   
                 TP53 
                 PP 
                 TNFSF6 
               
               
                   
                 TP53 
                 PP 
                 TP53I3 
               
               
                   
                 TP53 
                 PP 
                 NIG1 
               
               
                   
                 TP73 
                 PP 
                 NYC 
               
               
                   
                 TPA 
                 PP 
                 IL6 
               
               
                   
                 TPSB1 
                 PP 
                 TGFB1 
               
               
                   
                 TRAF2 
                 PP 
                 VAPK8 
               
               
                   
                 TRAF5 
                 PP 
                 VAPK8 
               
               
                   
                 tumor necrosis 
                 PP 
                 CDKN1A 
               
               
                   
                 factor 
               
               
                   
                 tumor necrosis 
                 PP 
                 NAPK3 
               
               
                   
                 factor 
               
               
                   
                 tumor necrosis 
                 PP 
                 NAPK8 
               
               
                   
                 factor 
               
               
                   
                 tumor necrosis 
                 PP 
                 RHOA 
               
               
                   
                 factor 
               
               
                   
                 TYK2 
                 PP 
                 IFNG 
               
               
                   
                 Type I protein gerenyl- 
                 PP 
                 INS 
               
               
                   
                 geranyltransferase 
               
               
                   
                 USF1 
                 PP 
                 USF2 
               
               
                   
                 VAV1 
                 PP 
                 NAOK8 
               
               
                   
                 VCAN1 
                 PP 
                 ICAN1 
               
               
                   
                 VCAN1 
                 PP 
                 NAPK14 
               
               
                   
                 VEGF 
                 PP 
                 ANGPT2 
               
               
                   
                 VEGF 
                 PP 
                 cANP-dependent protein 
               
               
                   
                   
                   
                 kinase catalyst 
               
               
                   
                 VEGF 
                 PP 
                 CSF1 
               
               
                   
                 VEGF 
                 PP 
                 EGFR 
               
               
                   
                 VEGF 
                 PP 
                 EGR1 
               
               
                   
                 VEGF 
                 PP 
                 F3 
               
               
                   
                 VEGF 
                 PP 
                 MAPK1 
               
               
                   
                 VEGF 
                 PP 
                 PRKCA 
               
               
                   
                 VEGF 
                 PP 
                 PTGS2 
               
               
                   
                 VEGF 
                 PP 
                 RAF1 
               
               
                   
                 VEGF 
                 PP 
                 RHOA 
               
               
                   
                 VEGF 
                 PP 
                 RPSBKP1 
               
               
                   
                 VEGF 
                 PP 
                 SERPINE1 
               
               
                   
                 VEGF 
                 PP 
                 SHC1 
               
               
                   
                 VEGF 
                 PP 
                 SRC 
               
               
                   
                 VEGF 
                 PP 
                 STAT3 
               
               
                   
                 VIP 
                 PP 
                 ADCY2 
               
               
                   
                 VIP 
                 PP 
                 CREB1 
               
               
                   
                 VIP 
                 PP 
                 LIF 
               
               
                   
                 WARS 
                 PP 
                 IFNG 
               
               
                   
                   
               
            
           
         
       
     
      The protein information database  3  also stores information about how the intermolecular interaction between two molecules affects the cellular function.  
      How the intermolecular interaction between two molecules affects the cellular function is inferred in the following way.  
      For a molecule set of NN-type, the following steps are taken to infer how the intermolecular interaction between two molecules affects the cellular function. The first step is to select the cellular function to be affected simultaneously by two proteins of the molecule set of interest. It is assumed that when the cellular function X is promoted by protein A and suppressed by protein B, and protein A is on and protein B is off, the molecule set of protein A and protein B promotionally acts on the cellular function X. Conversely, it is assumed that when the cellular function X is suppressed by protein A and promoted by protein B, and protein A is off and protein B is on, the molecule set of protein A and protein B promotionally acts on the cellular function X.  
      The protein information database  3  stores information about how the intermolecular interaction (between two molecules) affects the cellular function with respect to each protein of the molecule set of NN-type. As its example,  FIG. 3  shows the relation between the molecule set of NN-type relating to TP53 molecule and the cellular function that is promoted in response to on/off of the two proteins.  
      In the case of molecule set of NN-type involving TP53 and ABCC1 shown in  FIG. 3A , it promotes no cellular function when TP53 is on and ABCC1 is off, and it promotes synthesis and motility as the cellular function when TP53 is off and ABCC1 is on.  
      In the case of molecule set of NN-type involving TP53 and telomerase shown in  FIG. 3B , it promotes death and aging as the cellular function when TP53 is on and telomerase is off, and it promotes proliferation as the cellular function when TP53 is off and telomerase is on.  
      In the case of molecule set of NN-type involving TP53 and FGF2 shown in  FIG. 3C , it promotes apoptosis, metabolic catabolism, aging, DNA fragmentation, death, and depolarization as the cellular function when TP53 is on and FGF2 is off, and it promotes mitosis, chromosome DNA replication, replication, amplification, synthesis, growth rate increase, advance of cell cycle to S phase, motility, angiogenesis, proliferation, and advance of cell state to G1 phase as the cellular function when P53 is off and FGF2 is on.  
      In the case of molecule set of NN-type involving TP53 and TERT shown in  FIG. 3D , it promotes apoptosis, death, DNA damage recognition, and aging as the cellular function when TP53 is on and TERT is off, and it has no effect on the cellular function when P53 is off and TERT is on.  
      In the case of molecule set of NN-type involving TP53 and HSPA4 shown in  FIG. 3E , it promotes apoptosis, DNA fragmentation, and death as the cellular function when TP53 is on and HSPA4 is off, and it has no effect on the cellular function when P53 is off and HSPA4 is on.  
      In the case of molecule set of NN-type involving TP53 and TXNRD1 shown in  FIG. 3F , it has no effect on the cellular function when TP53 is on and TXNRD1 is off, and it promotes cell proliferation when TP53 is off and TXNRD1 is on.  
      Thus, the protein information database  3  stores any molecule set of NN-type involving other proteins than PT53 to show what cellular function is promoted when which protein is on.  
      For the relation between the cellular function and interaction between two molecules in the molecule set of PN-type, the molecule set of PN-type is assumed to positively act (POS) on the cellular function Y which is promoted by protein A and suppressed by protein B when promotive action is brought from protein A to protein B. Likewise, it is assumed to negatively act (NEG) on the cellular function Z which is suppressed by protein A and promoted by protein B.  
      The protein information database  3  stores information about the relation between the cellular function and the interaction between two molecules for proteins involved in the molecule set of PN-type. This is illustrated in FIGS.  4  to  9 , which show the relation between the cellular function and the molecule set of PN-type involving TP53.  
      In the case of molecule set of PN-type involving ADP and TP53 as shown in  FIG. 4A , ADP promotes the function of synthesis, motility, mitogenesis, and polymerization, and ADP suppresses the function of damage and DNA damage recognition. In the case of molecule set of PN-type involving AGTR2 and TP53 as shown in  FIG. 4B , AGTR2 promotes the function of synthesis and motility, and AGTR2 suppresses the function of cell permeability.  
      In the case of molecule set of PN-type involving catenin and TP53 as shown in  FIG. 4C , catenin promotes the function of motility and proliferation, and catenin does not suppress any specific function. In the case of molecule set of PN-type involving CCNE1 and TP53 as shown in  FIG. 4D , CCNE1 promotes the function of chromosomal DNA replication, condensation, proteolysis, synthesis, G1-S transition, instability, advance of cell cycle to S phase, motility, mitogenesis, and advance of cell cycle to G1 phase, and CCNE1 does not suppress any specific function.  
      In the same way as mentioned above, proteins involved in the molecule sets of PN-type shown in  FIGS. 4E  to  4 H and FIGS.  5  to  9  given later promote and suppress the cellular functions. This information is stored in the protein information database  3 .  
      The relation between the cellular function and interaction between two molecules is inferred in the same way as mentioned above for the molecule set of PP-type, that is, two proteins are regarded as “POS” (for promotion) and “NEG” (for suppression), respectively, if they promote and suppress the specifically selected cellular function on which they act simultaneously.  
      The protein information database  3  stores information about relation between the interaction of two molecules and the cellular function for the molecule set of PP-type involving various proteins. FIGS.  10  to  14  show, as some of their examples, how the cellular function is affected by the molecule set of PN-type involving TP53 molecule.  
      The molecule set of PN-type involving TP53 and PTEN as shown in  FIG. 10A  promotes the cellular function of apoptosis, chemosensitivity, and death if both proteins act for promotion, and it promotes the function of cell proliferation, advance of cell cycle to G1 phase, G1-S transition, advance of cell cycle to S phase, angiogenesis, growth rate increase, G0-G1 transition, mitogensis, and RNA localization if both proteins act for suppression. The molecule set of PN-type involving TP53 and ABCB1 as shown in  FIG. 10B  promotes the cellular function of apoptosis and secretion (release from cells of molecules produced inside cells) if both proteins act for promotion, and it does not promote any specific cellular function if both proteins act for suppression.  
      The molecule set of PN-type involving TP53 and GADD45A as shown in  FIG. 10C  promotes the cellular function of DNA nucleotide-excision repair if both proteins act for promotion, and it promotes the function of mitogenesis, S phase, G2 phase, G1 phase, and proliferation if both proteins act for suppression. The molecule set of PN-type involving TP53 and MYC as shown in  FIG. 10D  promotes the cellular function of apoptosis, death, and secretion, if both proteins act for promotion, and it does not promote any specific cellular function if both proteins act for suppression.  
      In the same way as mentioned above, proteins involved in the molecule sets of PN-type shown in  FIGS. 10E  to  10 G and FIGS.  11  to  14  given later promote and suppress the cellular functions. This information is stored in the protein information database  3 .  
      Now, the description of  FIG. 1  is revisited.  
      The protein information analyzing unit  4  includes the protein expression ratio arithmetic unit  21 , the point accumulating unit  22 , the factor setting unit  23 , the operating input acquisition unit  24 , the database building and processing unit  25 , the network building unit  26 , the target molecule inferring unit  27 , and the result output unit  28 .  
      The protein expression ratio arithmetic unit  21  receives from the mRNA expression analyzing unit  2  (or the protein kit  7 ) information about the amount of target protein expressed in normal cells and information about the amount of target protein expressed in sample cells. It compares the amount of target protein expressed in normal cells with the amount of target protein expressed in sample cells and calculates the increase or decrease of the amount of target protein expressed. It supplies the thus obtained value as the protein index to the point accumulating unit  22 .  
      The point accumulating unit  22  receives the value of protein index from the protein expression ratio arithmetic unit  21  and calculates the accumulated value of scores for individual cellular functions by using the value of protein index of two proteins constituting the molecule set of NN-type, PN-type, and PP-type stored in the protein information database  3  and the value of the factor set up in the factor setting unit  23 . If the point accumulating unit  22  gives a positive value of score for the cellular function, it means that the cell for detection promotes the cellular function; otherwise, it means that the cell for detection suppresses the cellular function.  
      The point accumulating unit  22  performs arithmetic process in the following manner for the molecule sets of NN-type, PN-type, and PP-type.  
      Association with cellular function and scoring are carried out as follows for the molecule set of NN-type involving INS and IFNG.  
      The point accumulating unit  22  receives from the protein expression ratio arithmetic unit  21  the values of protein index for the two proteins constituting the molecule set of NN-type and then calculates the absolute value of the difference between the two values. Subsequently, it assigns the absolute value to be positive or negative according to whether each cellular function is promoted or suppressed, and multiplies it by the factor set up by the factor setting unit  23 , thereby giving the score of the cellular function associated with the molecule set.  
      The cellular function associated with INS and IFNG for the molecule set of NN-type is classified into two categories as shown in  FIG. 15 . The first category includes those cellular functions which are promoted by INS (denoted by---&gt;) and suppressed by IFNG (denoted by---|). The second category includes those cellular functions which are suppressed by INS and promoted by IFNG. Those cellular functions which are promoted by INS and suppressed by IFNG include positive regulation of mitosis, mitogenesis, reorganization, G1 phase, transformation, assembling, proliferation, and morphogenesis. Those cellular functions which are suppressed by INS and promoted by IFNG include lypolysis, apoptosis, death, damage, rosette, permeation, and respiratory burst.  
      The point accumulating unit  22  receives the protein index of INS and the protein index of IFNG from the protein expression ratio arithmetic unit  21 . If the difference between the two indexes for the cellular function promoted by INS is larger than 0, it adds a positive sign to the absolute value of the difference. If the difference between the two indexes is smaller than 0, then it adds a negative sign to the absolute value of the difference. It multiplies the signed value by the factor set up in the factor setting unit  23 . The resulting value is the score of the cellular function controlled by the two proteins (shown in  FIG. 15 ).  
      Association with cellular function and scoring are carried out as follows for the molecule set of PN-type involving INS and JUN.  
      The point accumulating unit  22  receives from the protein expression ratio arithmetic unit  21  the value of protein index for either of the two proteins constituting the molecule set of PN-type which is promoted. It makes the value positive or negative according to whether the cellular function is promoted or suppressed and then multiplies it by the factor set up by the factor setting unit  23 , thereby giving the score of the cellular function associated with the molecule set.  
      The cellular function associated with INS and JUN for the molecule set of PN-type is classified into two categories as shown in  FIG. 16 . The first category includes those cellular functions which are promoted by INS and suppressed by JUN. The second category includes those cellular functions which are suppressed by INS and promoted by JUN. Those cellular functions which are promoted by INS and suppressed by JUN include steroid biosynthesis and mitogenesis. Those cellular functions which are suppressed by INS and promoted by JUN include DNA fragmentation and proteolysis. The point accumulating unit  22  makes positive the value of the protein index of INS for the cellular function promoted by the promoting protein (INS in the case in  FIG. 3 ), and it makes negative the value of the protein index for the cellular function suppressed by INS. Then it multiplies the resulting value by the factor set up by the factor setting unit  23 , thereby giving the score of the cellular function (shown in  FIG. 16 ) controlled by the two proteins.  
      Association with cellular function and scoring are carried out as follows for the molecule set of PP-type involving TNF and TP53.  
      The point accumulating unit  22  receives from the protein expression ratio arithmetic unit  21  the values of protein index for the two proteins constituting the molecule set of PP-type and then calculates their product. Subsequently, it assigns the product to be positive or negative according to whether each cellular function is promoted or suppressed, and multiplies it by the factor set up by the factor setting unit  23 , thereby giving the score of the cellular function associated with the molecule set.  
      The cellular function associated with INS and TP53 for the molecule set of PP-type is classified into two categories as shown in  FIG. 17 . The first category includes those cellular functions which are promoted by both proteins. The second category includes those cellular functions which are suppressed by both proteins. Those cellular functions which are promoted by both proteins include death, necrosis, damage, apoptosis, and secretion. Those cellular functions which are suppressed by both proteins include advance of cell cycle to G1 phase. The point accumulating unit  22  multiplies the product of indexes of both proteins by the factor set up by the factor setting unit  23  in the case of the cellular functions promoted by both proteins involved in the molecule set, thereby giving the score of the cellular function associated with the molecule set. The point accumulating unit  22  also multiplies the negative value of the product of indexes of both proteins by the factor set up by the factor setting unit  23  in the case of the cellular functions suppressed by both proteins involved in the molecule set, thereby giving the score of the cellular function associated with the molecule set.  
      The protein index is calculated in the following manner which is explained with reference to  FIG. 18  for typical 19 kinds of proteins involving cell interactions on the basis of data showing the expression of mRNA of DAOY (cultured cell of human medulloblastoma).  
      In  FIG. 18 , “ori” (original) denotes the ratio of the occurrence of a specific protein (out of 19 proteins) in the control target to the occurrence of a specific protein (out of 19 proteins) in the sample target.  
      The combination of 19 proteins (shown in  FIG. 18 ) gives the result of calculations for the molecule sets of NN-type. If the protein corresponding to the ordinate has a larger index than that corresponding to the abscissa, it means that the former is in the promotion (POS) side and hence the difference (in terms of absolute value) between the two indexes is obtained. If the protein corresponding to the ordinate has a smaller index than that corresponding to the abscissa, it means that the former is in the suppression (NEG) side and hence the difference (in terms of absolute value) between the two indexes is obtained. In other words, the difference between indexes of INS and IFNG is −0.40 for the corresponding cellular functions explained with reference to  FIG. 15 . This value is multiplied by the factor and the resulting product is assigned to be positive or negative according to whether the protein is in the promotion side or suppression side. The same calculations as above are performed on other molecule sets of NN-type.  
      The combination of 19 proteins (shown in  FIG. 18 ) indicates how the protein index of the protein in the promotion side is associated with the cellular function for the molecule set of PN-type. In other words, it gives the score (calculated by multiplying the cellular function promoted by INS by the factor of 1.00) for the molecule set of INS and JUN (explained above with reference to  FIG. 16 ). The same calculations as above are performed on other molecule sets of PN-type.  
      The combination of 19 proteins (shown in  FIG. 18 ) indicates the product of the index of the protein corresponding to the ordinate and the index of the protein corresponding to the abscissa. The molecule set involving TNF and TP53 (which has been explained with reference to  FIG. 17 ) gives the score obtained by multiplying −0.82 by the factor for the cellular function promoted by both proteins. The same calculations as above are performed on other molecule set of PP-type.  
      As mentioned above, the point accumulating unit  22  calculates the score of the cellular function (as explained with reference to FIGS.  15  to  18 ) for the molecule sets of NN-type, PN-type, and PP-type, and then accumulates the scores of individual cellular functions and supplies the results to the result output unit  28  and the target molecule inferring unit  27 .  
      The factor setting unit  23  sets up the factor for score accumulation to be executed by the point accumulating unit  22 . The factor should preferably be set up such that it takes the largest value for NN-type and the smallest value for PP-type. If there is a molecular bond between two molecules involved in the molecule set, the factor should be multiplied by a prescribed value larger than 1. These factors are previously obtained by experiment and experience; they may be set up in the factor setting unit  23  or may be changed by the user through processing in the operation input acquisition unit  24 .  
      The operation input acquisition unit  24  is an input device such as keyboard, mouse, touch pad, and touch panel, which receives inputs in response to the user&#39;s operation. It permits the user to change the setting of the factor in the factor setting unit  23 , to change the value of protein index in the simulation by the target molecule inferring unit  27  (mentioned later), and to update the database in the database building and processing unit  25 . It supplies the entry to the factor setting unit  23 , the target molecule inferring unit  27 , and the database building and processing unit  25 .  
      The database building and processing unit  25  updates and supplements various kinds of information stored in the protein information database  3  according to the user&#39;s input (which is supplied from the operating input acquisition unit  24 ) or database externally supplied through the network interface (not shown).  
      The target molecule inferring unit  27  performs simulation to infer the target molecule on the basis of score for each cellular function obtained from processing by the point accumulating unit  22 .  
      The target molecule inferring unit  27  simulates the change of score for cellular function which occurs when the protein index of specific molecule changes in the expression of mRNA of DAOY (cultured cell of human medulloblastoma), which was explained above with reference to  FIG. 18 .  
       FIG. 19  shows the value (which is not yet multiplied by the factor) as the base of the score for the cellular function corresponding to individual molecule sets. The factor α for the protein index of AKT1 and IL6 is 0.1. Incidentally, AKT1 and IL6 are included in the 19 proteins (involving the expression of mRNA of DAOY) which were explained above with reference to  FIG. 18 .  
      The value in  FIG. 19  differs from that in  FIG. 18  in that the score for cellular function associated with FOS and AKT1 for the molecular set of NN-type is one which is obtained by multiplying −10.09 by a prescribed factor, because each protein index of AKT1 and IL6 is multiplied by 0.1. In addition, there is a difference between  FIG. 19  and  FIG. 18  in the value as the base for the score of cellular function associated with the molecule set of PP-type involving AKT1 and IL6.  
       FIG. 20  shows how the score for cellular function changes when the base value of score for cellular function is multiplied by the factor and the results are accumulated as shown in  FIGS. 18 and 19 . The cellular functions which change in accumulated values as shown in  FIG. 20  are those which are seriously associated with cell proliferation and cell death. They include proliferation, apoptosis, cell survival, mitogenesis, angiogenesis, transformation, S phase, G2 phase, G2-M transition, G2 phase, G1-S transition, and G0-G1 transition.  
      As shown in  FIG. 20 , the score for cellular functions relating to proliferation, mitogenesis, angiogenesis, and transformation decreases and the score for cellular functions relating to apoptosis increases, with the factor α for AKT1 and IL6 set at 0.1.  
      The foregoing suggests that any treatment (with an anticancer agent, for example) to suppress the function of proteins (AKT1 and IL6) causes at least the cultured cell of human medulloblastoma (DAOY) to dye rather than proliferate. Finding a combination of proteins for the most remarkable effect will help search for the candidate of target molecule as an anticancer agent.  
      The target molecule inferring unit  27  may also be designed such that it performs simulation to infer the target molecule based on the protein network model built up by the network building unit  26 .  
      The network building unit  26  builds up the molecule network based on the information stored in the protein information database  3 .  FIG. 21  shows the molecule network drawn from the molecule set of NN-type. The molecule network may also be drawn for the molecule sets of other types. The molecule network is drawn separately for individual categories, and it is also drawn three-dimensionally according to relations among individual proteins.  
      Any increase or decrease of the index of a certain protein in the protein network model built up by the network building unit  26  affects the index of other proteins connected with the network. The target molecule inferring unit  27  simulates the change of index of individual proteins in the network to infer how an increase or decrease of protein index at one node affects the protein index at other nodes (adjacent to the node in which the protein index has changed), on the assumption that the effect in the first adjacent node is 50%, the effect in the second adjacent node is 30%, the effect in the third adjacent node is 10%, and so on. The protein network model built up by the network building unit  26  consists of more than one molecule network (similar to that shown in  FIG. 21 ) associated with one another, with their nodes connected with one another in a very complicated manner. It will permit more accurate inference of target molecules if it is modified such that consideration is given to the presence of the nodes which are affected through more than one route as the protein index increases or decreases.  
      The target molecule inferring unit  27  repeats the process of accumulating the score of cellular function by using the result of the simulation which has been carried out by means of the molecule network, thereby inferring the target molecule.  
      The result output unit  28  receives an accumulated score of cellular function from the point accumulating unit  22  or receives the result of inference of the target molecule from the target molecule inferring unit  27 , and then delivers it to either or both of the result display unit  5  and the result analyzing unit  6 .  
      The result display unit  5  consists of a display device such as CRT and LCD. It displays the result of accumulated score of cellular function or the result of inference of the target molecule which has been received from the result output unit  28 . The user will be able to perform input operation to infer the target molecule by reference to the result of accumulated score for cellular function which is displayed on the result display unit  5 .  
      The result analyzing unit  6  accumulates the result of accumulated score for cellular functions or the result of inference of the target molecule (which has been received from the result output unit  28 ) and then performs analysis according to need.  
      To be concrete, the result analyzing unit  6  accumulates chronologically the result of accumulated score for cellular functions of the same test subject and analyses the chronological change, so that it permits one to correctly judge whether or not the target protein has decreased as the result of medication to the test subject during the specific period. Moreover, it also permits one to confirm the effect (increase or decrease in expression) on other proteins or the effect on other cellular function by medication in that period.  
      This description is based on the assumption that the result analyzing unit  6  is independent of the protein information analyzing unit  4 . However, the former may be included in the latter.  
      The protein analyzing system according to the present invention permits one to analyze in a simple manner any system anomaly of disease caused by anomalous molecule network in cells (such as cancer).  
      In other words, the protein analyzing system according to the present invention classifies interactions between two molecules into five categories which are NN-type for two proteins suppressing each other, PN-type for two proteins, with the first one promoting the second one and the second one suppressing the first one, PP-type for two proteins promoting each other, P-type for two proteins, with the first one only promoting the second one, and N-type for two proteins, with the first one only suppressing the second one, and calculates and accumulates the score for the cellular function associated with the pair of proteins falling under any of these categories, thereby digitizing the cellular function. Combining this result with the variation of cellular function makes it possible to infer the system structure of cells.  
      The present invention makes it possible to analyze the relation between the cellular function and the intermolecular action of proteins instead of merely paying attention to a single molecule. Therefore, it permits one to investigate the change in cellular function which occurs when the amount of specific proteins expressed fluctuates. This capability may be used to simulate a combination to restore the normal state by changing the anomalous cellular function (resulting from cancer, for example). In this way it is possible to infer the target molecule important for medical treatment.  
      The target molecule important for medical treatment will be inferred by means of the molecule network consisting of nodes representing proteins and links representing interactions classified into five categories mentioned above. In this way it is possible to infer the target molecule more accurately.  
      Once a correct target molecule is inferred, it would be very useful to establish an adequate way of medication to restore the anomalous system resulting from diseases.  
      In what follows, the process for analysis by means of the protein analyzing system will be described with reference to  FIG. 22  (flow chart).  
      In Step S 1 , the chip forming unit  1  prepares a DNA chip to determine the amount of protein expressed (for analysis).  
      One DNA chip has more than one probe, so that it can determine the amount of more than one protein expressed.  
      In Step S 2 , the mRNA expression analyzing unit  2  carries out hybridization for the normal cell and the sample cell. To be concrete, this step is carried out as follows. The DNA chip, which has been prepared in Step S 1 , is given dropwise a target for control and a target for detection. The target for control is produced by using complementary DNA (cDNA) which has been replicated by reverse transcription from mRNA collected from normal cells. The target for detection is produced by reverse replication of complementary DNA (cDNA) from mRNA collected from sample cells. The probe and target are bound together (hybridized) through the reaction to form the complementary strands (double-strands) between the nucleic acids having the complementary base sequence.  
      In Step S 3 , the mRNA expression analyzing unit  2  calculates the amount of target protein expressed in normal cells and the amount of target protein expressed in sample cells, and then it sends the result to the protein expression ratio arithmetic unit  21  of the protein information analyzing unit  4 .  
      The detailed procedure for Step S 3  includes cleaning of the DNA chip, on which hybridization has occurred, and addition of an intercalator which emits fluorescence upon irradiation with exciting light, then the intercalator binds with the probe which has been hybridized. The intercalator binds with the probe in such a way that it does not enter between the probe and the target if they are not hybridized and it enters between the probe and the target only if they are hybridized. Upon irradiation with exiting light, the intercalator emits fluorescence, which is subsequently condensed by an object lens or the like and separated from exciting light by a prism. The condensed and separated fluorescence enters a photodiode for image analysis and calculation of the amount of target protein expressed.  
      In Step S 4 , the protein expression ratio arithmetic unit  21  of the protein information analyzing unit  4  calculates an increase or decrease in the amount of target protein expressed in the sample cells in comparison with the amount of target protein in the normal cells. Subsequently, it sends the result of calculations to the point accumulating unit  22 . In other words, the protein expression ratio arithmetic unit  21  calculates the protein index on the basis of the amount of target protein (control) expressed in the normal cells and the amount of target protein expressed in the sample cells, both of which have been supplied from the mRNA expression analyzing unit  2 . Then, it sends the result to the point accumulating unit  22 .  
      In Step S 5 , the point accumulating unit  22  calculates the point accumulation (mentioned later) according to the flow sheet shown in  FIG. 23 . It obtains the accumulated value of the score times the factor for each cellular function, and it sends the result to the result output unit  28  and the target molecule inferring unit  27 .  
      In Step S 6 , the result output unit  28  sends the result obtained in Step S 5  to either or both of the result display unit  5  and the result analyzing unit  6 .  
      In Step S 7 , the operating input acquisition unit  24  decides whether or not an instruction has been given to execute the target molecule inferring process.  
      In Step S 8 , the target molecule inferring unit  27  performs the process to infer the target molecule according to the flow sheets shown in  FIG. 24  or  25  (mentioned later), if it is judged in Step S 7  that an instruction has been issued to execute the process of inferring the target molecule.  
      In Step S 9 , the result analyzing unit  6  decides whether or not an instruction has been given to analyze the result of analysis of proteins which has been supplied from the result output unit  28  of the protein information analyzing unit  4 , if it is decided in Step S 7  that no instruction has been issued to execute the process of inferring the target molecule or after completion of the processing Step S 8 .  
      In Step S 10 , the result analyzing unit  6  chronologically analyzes the result of protein analysis if it is judged in Step S 9  that an instruction has been issued to analyze the result of protein analysis. The procedure for analysis includes accumulating chronologically the result of accumulation of the score for cellular function of the same test subject, analyzing the chronological changes, confirming whether or not the target protein has decreased as the result of medication to the test subject during the prescribed period, and confirming the effect on other proteins due to medication in the prescribed period or the effect on other cellular functions.  
      Step S 11  is to decide whether or not an instruction has been issued to terminate the processing if it is judged in Step S 9  that an instruction has been issued to analyze the result of protein analysis or after completion of the processing in Step S 10 .  
      The process returns to Step S 7  if it is decided in Step S 11  that no instruction for processing has been received from the user, and the steps after S 7  are repeated. The process ends if it is judged in Step S 11  that an instruction for processing has been received from the user.  
      The foregoing processing gives the score of cellular function in response to the amount of expression for individual molecule sets classified according to interactions between two molecules. The score of cellular function permits one to infer the target molecule and to analyze chronologically the result of protein analysis.  
      In what follows, the process for point accumulation to be performed in Step S 5  shown in  FIG. 22  will be described with reference to the flow chart shown in  FIG. 23 .  
      In Step S 41 , the point accumulating unit  22  extracts one of the molecule sets of NN-type, PN-type, or PP-type, which involves the proteins whose expression has been detected.  
      In Step S 42 , the point accumulating unit  22  extracts the factor, which has been set up by the factor setting unit  23 , according to the classification of the molecule sets (NN-type, PN-type, or PP-type) and the presence or absence of the molecular bond.  
      In Step S 43 , the point accumulating unit  22  detects whether each of cellular functions corresponding to the molecule sets is promoted or suppressed, by referencing the information about the relation between the molecule set and the cellular function shown in FIGS.  3  to  14  which is stored in the protein information database  3 .  
      Each of the cellular functions is associated with the molecule set as explained with reference to FIGS.  15  to  17 .  
      In Step S 44 , the point accumulating unit  22  multiplies by a factor the value as the base of the score (said value being obtained as explained with reference to  FIG. 18 ) for the cellular function corresponding to the molecule set, thereby calculating the score for the cellular function.  
      In Step S 45 , the point accumulating unit  22  decides whether or not the score has been added to all the molecule sets. If it is judged in Step S 45  that the score is not yet added to all the molecule sets, the step returns to Step S 41  and subsequent steps are repeated.  
      If it is decided in Step S 45  that the score has been added to all the molecule sets, the point accumulating unit  22  performs accumulation for each cellular function in Step S 46 , and the step returns to Step S 5  and proceeds to Step S 6  (shown in  FIG. 22 ).  
      The above-mentioned process accumulates the score for each cellular function, thereby allowing one to know which cellular function is promoted or suppressed in the sample cells.  
      In what follows, the target molecule inferring process  1  to be performed in Step S 8  shown in  FIG. 22  will be described with reference to the flow chart shown in  FIG. 24 .  
      The target molecule inferring process  1  infers the target molecule based only on the changed value of the protein index, without using the molecule network.  
      In Step S 71 , the operating input acquisition unit  24  decides whether or not it has received an input for the changed value of the protein index. If the operating input acquisition unit  24  decides in Step S 71  that it has not yet received an input for the changed value of the protein index, it repeats the process in Step S 71  until it judges that it has received an input for the changed value of the protein index.  
      In Step S 72 , the operating input acquisition unit  24  sends the value of the protein index entered to the target molecule inferring unit  27  if it is judged in Step S 71  that it has received an input for the changed value of the protein index. The target molecule inferring unit  27  sends the changed value of the protein index entered to the point accumulating unit  22 , thereby causing the point accumulating unit  22  to accumulate the point by using the changed protein index as explained with reference to  FIG. 19  in the same way as explained with reference to  FIG. 23 . The point accumulating unit  22  performs the process of accumulating the point by using the changed protein index and sends the result to the result output unit  28 .  
      In Step S 73 , the result output unit  28  sends the result of calculation which supplied from the point accumulating unit  22  to the result output unit  28  and the target molecule inferring unit  27 .  
      In Step S 74 , the operating input acquisition unit  24  decides whether or not it has received an input for the changed value of different protein index. If the operating input acquisition unit  24  decides in Step S 74  that it has received an input for the changed value of different protein index, the process returns to Step S 72  and the subsequent processes are repeated. If the operating input acquisition unit  24  judges in Step S 74  that it has not yet received an input for the changed value of different protein index, the process returns to Step S 8  shown in  FIG. 22  and proceeds to Step S 9 .  
      The foregoing process performs point accumulation by using the changed protein index as explained with reference to  FIG. 19 , and permits one to infer what cellular function is promoted or suppressed when what protein decreases in amount of expression as explained with reference to  FIG. 20 . This makes it possible to infer the candidate of the target molecule for anticancer agents by seeking a protein or a combination of proteins which is most effective for the desired cellular function.  
      In what follows, the target molecule inferring process  2  to be performed in Step S 8  shown in  FIG. 22  will be described with reference to the flow chart shown in  FIG. 25 .  
      The target molecule inferring process  2  infers the target molecule by simulating the changed value of protein index for a plurality of molecules by using the molecule network.  
      In Step S 101 , the operating input acquisition unit  24  decides whether or not it has received an input for the changed value of the protein index. If the operating input acquisition unit  24  decides in Step S 101  that it has not yet received an input for the changed value of the protein index, it repeats the process in Step S 101  until it judges that it has received an input for the changed value of the protein index.  
      In Step S 101 , the operating input acquisition unit  24  sends the value of the protein index entered to the target molecule inferring unit  27  if it is decided in Step S 101  that it has received an input for the changed value of the protein index. The target molecule inferring unit  27  sends the changed value of the protein index entered to the network building unit  26 , thereby causing the network building unit  26  to calculate the variation of the protein index at individual nodes that occurs when the value of the prescribed protein index is changed in the molecule network built up by the network building unit  26 . The network building unit  26  calculates the variation of the protein index at each node based on the changed value of the protein index supplied, and sends the result to the point accumulating unit  22 .  
      It is desirable to have a means for considering the presence of nodes under influence of more than one route for the increase or decrease of the protein index at a certain node.  
      In Step S 103 , the point accumulating unit  22  accumulates the point by using the protein index after simulation in the same way as explained with reference to  FIG. 23 .  
      In Step S 104 , the result output unit  28  sends the result of calculation (which has been received from the point accumulating unit  22 ) to the result output unit  28  and the target molecule inferring unit  27 .  
      In Step S 105 , the operating input acquisition unit  24  decides whether or not it has accepted the input of the changed value of the different protein index. If it is decided in Step S 105  that the input of the changed value of the different protein index has been accepted, the process returns to Step S 102  and the subsequent process is repeated. If it is decided in Step S 105  that the input of the changed value of the different protein index has not been accepted, the process returns to Step S 8  shown in  FIG. 22  and then proceeds to Step S 9 .  
      The above-mentioned process accumulates the score for cellular function once again by using the result of simulation by means of the molecule network, thereby allowing one to infer the target molecule.  
      A series of processes mentioned above may be implemented by means of hardware or software. At least part of the above-mentioned process may be carried out by means of the personal computer  101  shown in  FIG. 26 .  
      In  FIG. 26 , the CPU (Central Processing Unit)  111  executes various processes according to the program stored in the ROM (Read Only Memory)  112  or the program loaded from the memory  118  to the RAM (Random Access Memory)  113 . The RAM  113  also stores data necessary for the CPU  111  to perform various processes.  
      The CPU  111 , the ROM  112 , and the RAM  113  are connected to one another through the internal bus  114 , which is connected to the input/output interface  115 .  
      The input/output interface  115  is connected to the input device  116  such as keyboard and mouse, the output device  117  such as display and speaker, the memory unit  118  such as hard disk, and the communication unit  119  such as modem and terminal adaptor. The communication unit  119  performs communications through various networks including telephone circuit and CATV.  
      The input/output interface  115  is connected to the drive  120  according to need. The drive  120  may be equipped with the removable medium  121 , such as magnetic disc, optical disc, magneto-optical disc, and semiconductor memory. The computer program is read out from the drive  120  and then installed in the memory  118  according to need.  
      In the case where software is used for processing, the program constituting the software is installed from the network or recording medium.  
      The recording medium may be the ROM  112  in which the program is recorded or the hard disc included in the memory device  118 . In this case the ROM  112  and the hard disc are built into the personal computer delivered to the user. The program may also be recorded in the removal medium  121 , which is distributed to the user separately from the computer proper.  
      In this specification, the steps for the program recorded in the recording medium may be carried out chronologically in the order listed; however, they may also be carried out in parallel or independently.  
      In this specification, the term “system” denotes an entire apparatus including a plurality of devices.  
      Incidentally, the embodiments of the present invention are not limited to those mentioned above; they may be modified variously without departing from the scope of the present invention.