Patent Publication Number: US-2006003327-A1

Title: Peripheral blood cell markers useful for diagnosing multiple sclerosis and methods and kits utilizing same

Description:
FIELD AND BACKGROUND OF THE INVENTION  
      The present invention relates generally to the field of diagnosis, treatment assessment and prognosis. More specifically, the present invention relates to peripheral blood cell expressed markers and kits and methods utilizing same for diagnosing, treating and assessing the state of multiple sclerosis (MS) in an individual. The present invention also provides cellular markers which are useful in distinguishing between different clinical courses of MS e.g.: probable, relapsing-remitting, secondary progressive or primary progressive as well as response to the therapy.  
      Multiple sclerosis is an autoimmune neurodegenerative disease, which is marked by inflammation within the central nervous system with lymphocyte attack against myelin produced by oligodendrocytes, plaque formation and demyelization with destruction of the myelin sheath of axons in the brain and spinal cord, leading to significant neurological disability over time. The disease frequently occurs in young adults between 20-40 years of age, is more prevalent in females than males (2:1), and has a characteristic geographical distribution—estimated prevalence in USA 120/100,000, (250,000 to 350,000 cases).  
      The annual cost of MS in USA was estimated about $34,000 per person, $2.2 million total lifetime cost per case or $6.8 billion yearly, in a conservative estimate of a national annual cost (Anderson D W, 1992; Whetten-Goldstain K., 1998).  
      Clinical Diagnosis and Evaluation of Stages of MS  
      Typically, at onset an otherwise healthy person presents with the acute or sub acute onset of neurological symptomatology (attack) manifested by unilateral loss of vision, vertigo, ataxia, dyscoordination, gait difficulties, sensory impairment characterized by paresthesia, dysesthesia, sensory loss, urinary disturbances until incontinence, diplopia, dysarthria or various degrees of motor weakness until paralysis. The symptoms are usually painless, remain for several days to a few weeks, and then partially or completely resolve. After a period of remission, a second attack will occur. During this period after the first attack, the patient is defined to suffer from probable MS. Probable MS patients may remain undiagnosed for years. When the second attack occurs the diagnosis of clinically definite MS (CDMS) is made (Poser criteria 1983; C. M. Poser et al., Ann. Neurol. 1983; 13, 227).  
      The clinical disease courses of MS are relapsing-remitting, primary or secondary progressive (Abramsky, 1997; Russell, 1998).  
      The relapsing-remitting course of MS (85% of patients) is characterized by acute attacks or relapses during which new neurological symptoms and signs appear, or worsen. Relapse develops within a period of several days, lasts for 6-8 weeks, than gradually resolves. During the acute relapse scattered inflammatory and demyelinating central nervous system (CNS) lesions produce varying combinations of motor, sensory, coordination, visual, and cognitive impairments, as well as symptoms of fatigue and urinary tract dysfunction. The outcome of a relapse is unpredictable in terms of neurological sequel but it is well established that with additional relapses, the probability of complete clinical remission decreases and neurological disability and handicap may develop. On average, about 60% of patients remain fully functional 10 years after the primary attack, and 25 to 30% remain fully functional 30 years after onset. Statistically, the disease does not greatly decrease life expectancy (mean decrease 12 years), although some patients become severely disabled and die from recurrent infections and complications.  
      Primary progressive MS (10% of patients) is characterized by slow, progressive neurological dysfunction usually in the form of a gradual myelopathy causing spasticity and ataxia. Treatment regimen varies greatly with different clinical course and severity of the disease.  
      The diagnosis of MS is still defined primary by clinical terms and relies on a combination of history, neurological examination and ancillary laboratory and neuro-imaging studies.  
      Laboratory tests for MS include: 1) CSF evaluation of IgG synthesis, oligoclonal bands; 2) MRI of the brain and spinal cord and; 3) exclusion of other autoimmune diseases by blood tests [e.g.; serum B12 level; HTLV 1 or HIV 1 titers; sedimentation rate or C-reactive protein; RA latex (Rheumatoid arthritis); ANA, anti-DNA antibodies (systemic lupus erythematosus)]. However, accurate diagnosis and prognosis in the “probable” stage, and early relapsing-remitting stages remains problematic. For example, it has been shown that positive MRI findings in the first demyelinating attack only provide a 50% successful prediction of development of clinically definite MS within 2-3 years (CHAMPS Study Group, Neurology 2002; 59:998-1005). Likewise, Villar et al (Neurology 2002; 59:877-83) found that detection of oligoclonal IgM bands with early symptoms were only partially predictive of development of clinically definite MS.  
      Other laboratory tests may provide some additional support for the diagnosis, but evidence of lesions disseminated in time and space remains a cardinal element of the diagnosis (Poser C M., 2001). In absence of definitive laboratory tests and pathognomonic clinical features, MS remains ultimately a diagnosis of exclusion.  
      Diseases that may be confused with MS are: 1) Acute disseminated encephalomyelitis (follows infections or vaccination mainly in children, fever, headaches, and meningitis common), 2) Lyme disease (antibodies to  Borrelia  species antigens in serum and CSF), 3) HIV associated myelopathy (HIV antibodies present), 4) HTLVI myelopathy (HTLVI antibodies present in serum/CSF), 5) Neurosyphilis (syphilis antibodies present in serum and/or CSF, 6) Progressive multifocal leukoencephalopathy (biopsy of lesions demonstrates virus by electron microscopy), 7) Systemic lupus erythematosus (CNS manifestations of lupus, antinuclear antibodies, anti-dsDNA), 8) Polyarteritis nodosa (systemic signs, micro-aneurysms demonstrated by angiographies, vasculitis demonstrated in biopsy of involved areas), 9) Sjogren&#39;s syndrome (dry eyes and mouth, antiRo and antiLa antibodies), 10) Behcet&#39;s disease (Oral/genital ulcers, antibodies to oral mucosa), 11) Sarcoidosis (CNS signs, increased protein in CSF, biopsy shows granuloma, 12) Paraneoplastic syndromes (older age group, antiYo antibodies), 13) Subacute combined degeneration of cord (peripheral neuropathy, vitamin B12 levels), 14) Sub acute myeloopticoneuropathy (adverse reaction to chlorhydroxyquinoline, mainly in Japanese), 15) Hereditary spastic paraparesis/primary lateral sclerosis (normal CSF, MRI and visual evoked potential studies), 16) Adrenomyeloneuropathy (adrenal dysfunction, neuropathy, increased plasma very long-chain fatty acids), 16) Spinocerebellar syndromes (familial, pes cavus scoliosis, abnormal reflexes, normal CSF IgG), 17) Miscellaneous—strokes, tumors, arteriovenous malformations, arachnoid cysts, Arnold-Chiari malformations, and cervical spondylosis all may lead to diagnostic dilemmas on occasion. Thus, detailed history and neurological examination must be complemented by specific laboratory tests for the correct diagnosis of MS. Clearly there is a long felt need for more powerful diagnostic tools for prediction and staging of MS.  
      Etiology of MS  
      The etiology of MS is unknown. It is suggested that a combination of genetic background and environmental factors and immune response are involved in the disease. A certain incidence of familial occurrence has been observed, with the concordance rate among monozygotic twins being 30%, a 10-fold increase over that in dizygotic twins or first-degree relatives (Steinman, 1966; Dyment et al Mol. Gen 1997; 6:1693-98). In addition, recent research indicates that the tissue damage in MS occurs as the result of pathological autoimmune responses to several myelin antigens following exposure to an as yet undefined environmental causal agent.  
      However, although some environmental factors have been statistically associated with the disease, none have provided correlations of any predictive value. Environmental factors seem to trigger MS in subjects who are already genetically susceptible to the illness. Most probably no one dominant gene determines genetic susceptibility, but rather many genes, each with different influence, are involved. Indeed, the initial pathogenic process could be caused by one group of genes, while others groups could be responsible for the development and progression of the disease (Oksenberg, 2001; Compston, 1997).  
      Microarray Analysis and MS  
      Microarray technology is based on hybridization of mRNA to high-density array of immobilized target sequences. Each sequence corresponds to a specific gene(s) of interest. The labeled pool of sample mRNA is subsequently hybridized to the array (chip). Application of this technology provides the capability of monitoring thousands of various genes simultaneously. Today commercial available DNA microarrays (Affymetrix, Santa Clara Calif., USA) contain elements representing 10,000, 20,000 or more genes that have been characterized in terms of function or disease association. The preparation and use of microarrays for diagnostics, research and drug development is disclosed in, inter alia, U.S. Pat. Nos. 6,324,497 and 6,468,476 to Friend et al and 6,410,229 to Lockhart et al; and Intnl Pat. Application WO 0053625C2 and A2.  
      Several application of microarrays in human disease have been reported, for example the identification (marker) genes involved in ovarian carcinogenesis (Ono K., 2000); classification of genes expression profiling of cutaneous malignant melanoma (Bitter M., 2000); and expression profile of Tangl-Rearing CA1 neurons in Alzheimer&#39;s disease (Stephen, 2000). Alizaden (2000) characterized gene expression in diffuse large B cell lymphoma, where two distinct gene expression patterns, characterized by different molecular forms of B cells lymphoma, were identified. In addition, microarray technology has also been applied to diagnosis and monitoring of such diverse diseases as cancer (U.S. Pat. No. 6,511,849 to Freuhauf et al), psoriasis (Intnl Pat. Application WO 20020027538 to Trepicchio et al), T-helper cell related diseases (Trepicchio et al, Intnl Pat Application WO 20020039734), Epstein-Barr disease (U.S. Pat. Nos. 6,506,553 and 6,468,476 to Smith and Parks), rheumatoid arthritis (Intnl Pat Application WO 0248310A2 to Trepicchio et al) and Reward Deficiency Syndrome, all of which are incorporated herein by reference.  
      In a recent review (Greenberg S A., 2001) the author discussed the potential application of DNA microarray technology for understanding neurological disorders. Using cDNA microarrays technology, brain tissue from pathology lesions and normal white matter of single MS patient were analyzed (Whitney L W., 1999). Blood genomic fingerprints were demonstrated after experimental strokes, seizures, hypoglycemia and hypoxia of rats (Yang Tang, 2001). Similarly, microarray analysis of gene expression in brainstem and spinal cord tissues from the animal models of MS (experimental autoimmune encephalomyelitis, EAE) has identified a number of differentially expressed genes from active-acute versus silent lesions (Lock C. et al Nat Med 2002; 8,500-504), and also suggested a role for the proinflammatory cytokine osteopontin in the development of EAE in mice (Chabas D et al Science 2001; 294:1731-34).  
      In another recent study, Ramanathan M et al (J of Immunology 2001; 116:213-19) used cDNA microarray technology to identify abnormal gene expression patterns in PBMC of relapsing-remitting MS patients. The study compared PBMC gene expression in 15 patients during remission (only) with that of 15 healthy controls, using a GeneFilters GF211 array (Research Genetics, Huntsville Ala., USA) having approximately 5200 human gene sequences. Groups of marker genes correlated with MS were disclosed, but the range of differences (fold changes) between level of gene expression in MS and control groups was only 13 to 35% for unregulated and from 11 to 43% for down regulated genes. Such small differences are probably due to the limited sensitivity of the technology employed in using GeneFilters arrays, and may not have any clinical or diagnostically mining significance. More significantly, the population of MS patients was limited, including only patients during clinical remission, who had not received any immunosupressive treatment for at least 3 months. Thus, the markers described do not provide a profile of expression patterns useful for diagnosing clinically defined MS in patients having probable MS, or for determining stages of the disease.  
      Trepicchio et al. (Intnl Pat. Application No. WO 02/079218 A1) also describe the use of microarray technology in determining characteristic gene expression in an animal model of MS (murine EAE) and in tissue samples from MS patients. The human samples were PBMC or brainstem tissue, collected from 60 patients manifesting a wide variety of symptoms, at different stages of MS including relapsing-remitting, primary and secondary progressive, and acute exacerbation. RNA probes prepared from these samples were hybridized to a human chip array containing approximately 14,000 gene sequences (MicroArray, Affymetrix, cat no. 510448, Santa Clara Calif.), and expression profiles compared with those of healthy controls. Determination of the panel of “MS-related” markers was based merely on fold change of greater than 2 fold (up- or downregulated), with a confidence level of p&lt;0.01. No more stringent statistical criteria were applied. A “panel” of 300 differentially regulated genes was thus described in the PBMC samples, and another 100 in the brain lesion tissue. However, no classification of expression profiles characteristic to specific stages of the disease was provided, and the “class predictor model”, as described, using “neighborhood analysis”, was applied for attempted prediction of “MS-afflicted” or “non-diseased” samples only. Thus, the panel of markers described is not applicable to the diagnosis of stage of MS, in general, is unsuited for the prediction of clinically definite MS or probable MS patients, and is clearly non-predictive in monitoring response to treatment.  
      There is thus a widely recognized need for, and it would be highly advantageous to have gene expression profiles useful in distinguishing between different forms of MS e.g.: probable, relapsing-remitting, primary or secondary as well as response to the therapy, devoid of the above limitations.  
     SUMMARY OF THE INVENTION  
      According to one aspect of the present invention there is provided a method of diagnosing a subject with multiple sclerosis, the method comprising determining a level of expression of at least one gene selected from the group consisting of the genes listed in Tables I-V in a sample obtained from the subject, wherein a substantial difference between the level of expression of the gene in the sample obtained from the subject and a normal expression level of the gene is an indication that the subject is afflicted with multiple sclerosis.  
      According to further features in preferred embodiments of the invention described below a method of monitoring a state of multiple sclerosis in a subject, the method comprising monitoring a level of expression of at least one gene selected from the group consisting of the genes listed in Tables I-V over a predetermined time period, wherein substantial difference between the levels of expression of the at least one gene over the predetermined time period indicates a change in a state of the multiple sclerosis in the subject.  
      According to further features in preferred embodiments of the invention described below monitoring the level of expression of at least one gene over the predetermined time period is effected by periodically obtaining a sample from the individual and determining the level of expression of the at least one gene in the sample.  
      According to still further features in the described preferred embodiments the at least one gene comprises at least 10, at least 50, at least 100, at least 250, at least 500, at least 750, at least 1000 or at least 1200 genes each independently selected from the group consisting of the genes listed in Tables I-V.  
      According to another aspect of the present invention there is provided a method of diagnosing a subject with multiple sclerosis, the method comprising the step of determining a level of expression of each of the genes listed in Tables I-V in a sample obtained from the subject, wherein a substantial difference between expression levels of the genes in the sample obtained from the subject and normal expression levels of the genes is an indication that the subject is afflicted with multiple sclerosis.  
      According to further features in preferred embodiments of the invention described below the normal expression level of the at least one gene or genes is determined by measuring the level of expression of the gene or genes in at least one control sample obtained from at least one healthy individual.  
      According to still further features in the described preferred embodiments the sample includes peripheral blood mononuclear cells.  
      According to yet further features in the described preferred embodiments the substantial difference is a difference statistically significant at a confidence level of p=0.05 as determined by at least one test selected from the group consisting of a t-test, a TNoM and an INFO score.  
      According to further features in preferred embodiments of the invention described below the level of expression of the at least one gene or genes is determined by quantifying a level of a protein product thereof in the sample. According to still further features in the described preferred embodiments quantifying a level of the protein is effected using a reagent which specifically binds with the protein.  
      According to yet further features in preferred embodiments of the invention described below the reagent comprises an antibody or fragments thereof.  
      According to further features in preferred embodiments of the invention described below the at least one gene or genes are selected from the genes listed in Table I.  
      According to still further features in preferred embodiments of the invention described below the at least one gene or genes are selected from the genes listed in Table II.  
      According to yet further features in preferred embodiments of the invention described below the at least one gene or genes are selected from the genes listed in Table III.  
      According to further features in preferred embodiments of the invention described below the at least one gene or genes are selected from the genes listed in Table IV.  
      According to still further features in the described preferred embodiments at least one gene or genes are selected from the genes listed in Table V.  
      According to yet further features in preferred embodiments of the invention described below the level of expression of the at least one gene or genes in the sample is determined by detecting the presence in the sample of a transcribed polynucleotide or portion thereof. The transcribed polynucleotide can be mRNA.  
      According to further features in preferred embodiments of the invention described below the transcribed polynucleotide or portion thereof is detected via a labeled probe which specifically hybridizes with the transcribed polynucleotide or portion thereof.  
      According to still further features in the described preferred embodiments the sample from a subject is T cells, the at least one gene or genes are selected from the genes listed in Table IV and the normal expression of the gene or genes is T-cell expression.  
      According to an additional aspect of the present invention there is provided a method of assessing the efficacy of a treatment regimen on multiple sclerosis in a subject, the method comprising determining a level of expression of at least one gene or genes selected from the group consisting of the genes listed in Tables I-V in samples obtained from the subject prior to, and following exposure to the treatment regimen, wherein a substantial difference in the expression level of at least one gene or genes between the samples is an indication that the treatment regimen is efficacious in treating multiple sclerosis in the subject.  
      According to further features in preferred embodiments of the invention described below the treatment regimen is administering at least one test compound for inhibiting multiple sclerosis.  
      According to still further features in the described preferred embodiments the treatment regimen is an environmental condition.  
      According to yet further features in the described preferred embodiments the substantial difference is a difference statistically significant at a confidence level of p=0.05 as determined by at least one test selected from the group consisting of a t-test, a TNoM and an INFO score.  
      According to further features in preferred embodiments of the invention described below the level of expression of the at least one gene or genes is determined by quantifying a level of a protein product thereof in the sample.  
      According to still further features in the described preferred embodiments quantifying a level of the protein is effected using a reagent which specifically binds with the protein.  
      According to yet further features in preferred embodiments of the invention described below the reagent comprises an antibody or fragments thereof.  
      According to further features in preferred embodiments of the invention described below the at least one gene or genes are selected from the genes listed in Table I.  
      According to still further features in preferred embodiments of the invention described below the at least one gene or genes are selected from the genes listed in Table II.  
      According to yet further features in preferred embodiments of the invention described below the at least one gene or genes are selected from the genes listed in Table III.  
      According to further features in preferred embodiments of the invention described below the at least one gene or genes are selected from the genes listed in Table IV.  
      According to still further features in the described preferred embodiments at least one gene or genes are selected from the genes listed in Table V.  
      According to yet further features in preferred embodiments of the invention described below the level of expression of the at least one gene or genes in the sample is determined by detecting the presence in the sample of a transcribed polynucleotide or portion thereof. The transcribed polynucleotide can be mRNA.  
      According to further features in preferred embodiments of the invention described below the transcribed polynucleotide or portion thereof is detected via a labeled probe which specifically hybridizes with the transcribed polynucleotide or portion thereof.  
      According to still further features in the described preferred embodiments the sample from a subject is T cells, the at least one gene or genes are selected from the genes listed in Table IV and the normal expression of the gene or genes is T-cell expression.  
      According to still further features in the described preferred embodiments the at least one gene comprises at least 10, at least 50, at least 100, at least 250, at least 500, at least 750, at least 1000 or at least 1200 genes each independently selected from the group consisting of the genes listed in Tables I-V.  
      According to another aspect of the present invention there is provided a kit for diagnosing multiple sclerosis in a subject, the kit comprising components suitable for determining expression levels of at least one gene selected from the group of genes listed in Tables I-V.  
      According to further features in the described preferred embodiments the reagents include at least one polynucleotide sequence selected capable of specifically hybridizing with an transcription product of the at least one gene and reagents for detecting and optionally quantifying a complex formed from the at least one polynucleotide sequence and said transcription product.  
      According to still further features in the described preferred embodiments the reagents include at least one antibody selected capable of specifically binding a polypeptide product of the at least one gene and reagents for detecting and optionally quantifying a complex formed from the at least one antibody and the polypeptide product.  
      According to further features in preferred embodiments of the invention described below the at least one gene is selected from the genes listed in Table I.  
      According to still further features in preferred embodiments of the invention described below the at least one gene is selected from the genes listed in Table II.  
      According to yet further features in preferred embodiments of the invention described below the at least one gene is selected from the genes listed in Table III.  
      According to further features in preferred embodiments of the invention described below the at least one gene is selected from the genes listed in Table IV.  
      According to still further features in the described preferred embodiments at least one gene is selected from the genes listed in Table V.  
      According to further features in preferred embodiments of the invention described below the kit further comprises packaging material identifying the kit as useful from diagnosing MS.  
      According to another aspect of the present invention there is provided a polynucleotide array comprising at least 10 and no more than 1500 polynucleotide sequences, wherein each of the sequences is selected capable of hybridizing with a transcription product of a polynucleotide sequence of a gene selected from the group of genes listed in Tables I-V.  
      According to further features in preferred embodiments of the invention described below the array is selected having polynucleotide sequences capable of diagnosing subjects suspected of suffering from multiple sclerosis. The subjects may also be suspected of suffering from probable multiple sclerosis, primary progressive multiple sclerosis, secondary progressive multiple sclerosis, and/or relapsing/remitting multiple sclerosis.  
      According to further features in preferred embodiments of the invention described below the gene is selected from the genes listed in Table I, II, III, IV and/or IV.  
      According to yet another aspect of the present invention there is provided an array comprising at least 10 and no more than 1500 antibodies or antibody fragments each capable of specifically binding a protein product of a gene selected from the group of genes listed in Tables I-V.  
      According to further features in preferred embodiments of the invention described below the array is selected having antibodies or antibody fragments capable of diagnosing subjects suspected of suffering from multiple sclerosis. The subjects may also be suspected of suffering from probable multiple sclerosis, primary progressive multiple sclerosis, secondary progressive multiple sclerosis, and/or relapsing/remitting multiple sclerosis.  
      According to further features in preferred embodiments of the invention described below the gene is selected from the genes listed in Table I, II, III, IV and/or IV.  
      Implementation of the method and system of the present invention involves performing or completing selected tasks or steps manually, automatically, or a combination thereof. Moreover, according to actual instrumentation and equipment of preferred embodiments of the method and system of the present invention, several selected steps could be implemented by hardware or by software on any operating system of any firmware or a combination thereof. 
    
    
     BRIEF DESCRIPTION OF THE DRAWINGS  
      The invention is herein described, by way of example only, with reference to the accompanying drawings. With specific reference now to the drawings in detail, it is stressed that the particulars shown are by way of example and for purposes of illustrative discussion of the preferred embodiments of the present invention only, and are presented in the cause of providing what is believed to be the most useful and readily understood description of the principles and conceptual aspects of the invention. In this regard, no attempt is made to show structural details of the invention in more detail than is necessary for a fundamental understanding of the invention, the description taken with the drawings making apparent to those skilled in the art how the several forms of the invention may be embodied in practice.  
      In the drawings:  
      FIGS.  1 A-B are graphic representations of the differences in PMBC gene expression between MS patients and healthy subjects. RNA from Peripheral Blood Mononuclear Cells (PMBC) of 26 patients diagnosed with MS, and 18 healthy, age-matched controls was purified, labeled hybridized to a Genechip array (U95Av2, Affymetrix Inc. Santa Clara Calif., USA), scanned and analyzed according to manufacturer&#39;s recommendations. The data were normalized and fold ratios calculated for each gene of the MS samples against the geometric mean of the controls.  FIG. 1A  shows the number of MS specific genes detected having increased expression (fold change greater than 1.5) analyzed by t-test (red line), TNoM (green line) and INFO (blue line), compared with random occurrence (black line), at confidence levels (False Discovery Rates, FDR) of 90% (p=0.10) to 100% (p=0). Note the high level of significant MS-related gene expression at 95% FDR and above (arrows) (1249 distinguished genes).  FIG. 1B  is an infogram of the 1249 genes most significantly (p&lt;0.05 on all three tests) distinguishing MS patients (MS) from (control) healthy controls, determined as above. Each spot represents expression of a specific gene; color intensity of overexpressed (green) and under-expressed (red) genes indicates fold increase as compared to controls. Gray color indicates genes showing no difference in expression between MS and controls.  
      FIGS.  2 A-B are graphic representations of the differences in PMBC gene expression between MS patients during acute relapse, and MS patients in remission. RNA from PMBC of 12 relapsed, and 14 clinically in remission patients was purified, labeled, hybridized and analyzed as described for FIGS.  1 A-B hereinabove.  FIG. 2A  shows the number of acute relapse-specific genes detected having increased expression in relapse, as analyzed by t-test (red line), TNoM (green line) and INFO (blue line), compared with random occurrence (black line), at confidence levels (False Discovery Rates, FDR) of 90% (p=0.10) to 100% (p=0). 735 genes were detected having significant relapsing-related gene expression at 95% FDR and above.  FIG. 2B  is an infogram analysis of the 735 genes most significantly (p&lt;0.05 on all three tests) distinguishing acute relapsing MS patients (Relapse) from MS patients in remission (Remission). Note the different profiles of gene expression in patients undergoing treatment (Relapse+ and Remission+) compared with untreated patients (Relapse− and Remission−).  
       FIG. 3  is a pie chart diagram showing the breakdown, by functional character, of specific genes displaying up- or down-regulation in MS-derived MOG-reactive T-cell lines, as compared to normal-derived MOG-reactive T-cell lines. Significant MOG reactive MS-related genes are defined as genes with TNOM=0 and p=0.057 as compared to normal MOG-reactive T-cells.  
       FIG. 4  is a graphic representation of the differences in gene expression between MOG-stimulated T-cell lines from MS patients and healthy controls. RNA from MOG-stimulated T-cells of 4 MS patients and 3 matched controls was purified, labeled, hybridized and analyzed as described for FIGS.  1 A-B hereinabove. Panel A shows a cluster analysis of 150 differentially expressed genes analyzed as described hereinabove (TNoM=0, p&lt;0.05) distinguishing T-cells of MS (MS) patients from controls (Controls). Panel B shows a cluster analysis of the 43 most informative genes (TNoM=0, p&lt;0.05, and fold change&gt;1.5). Each row represents a gene, and each column represents a T-cell line form a different subject. Yellow color indicates genes with an increased expression relative to controls are yellow, and blue color indicates genes with relative decreased expression. 
    
    
     DESCRIPTION OF THE PREFERRED EMBODIMENTS  
      The present invention is of methods and kits for diagnosing multiple sclerosis in subjects, using novel gene expression profiles derived from peripheral blood cells. Specifically, the present invention can be used to diagnose MS in early stages of the disease, to determine clinical stage and predict the course of the disease in patients with a unclear diagnoses, to provide definition and prognostic information in patients with probable MS, to assess and monitor MS therapies and to screen new and established drugs and treatments for MS.  
      The principles and operation of the present invention may be better understood with reference to the drawings and accompanying descriptions.  
      Before explaining at least one embodiment of the invention in detail, it is to be understood that the invention is not limited in its application to the details of construction and the arrangement of the components set forth in the following description or illustrated in the Examples and drawings. The invention is capable of other embodiments or of being practiced or carried out in various ways. Also, it is to be understood that the phraseology and terminology employed herein is for the purpose of description and should not be regarded as limiting.  
      The present invention provides previously unavailable accuracy in predicting and staging MS, by identifying genes and groups of genes specifically over- and under-expressed in PBMC of patients at various stages of their disease.  
      As is further described in the Examples section which follows, the present inventors have conducted a broad scale analysis of PMBC expressed genes using hybridization of biotin-labeled PBMC mRNA to more than 12,000 human gene sequences provided on DNA chips. By utilizing specialized statistical analysis approaches, the present inventors identified in the microarray data the most highly informative expression profiles.  
      As mentioned hereinabove, multiple sclerosis is a chronic, multi-factorial neurodegenerative disease of unknown etiology, the diagnosis and classification of which remains largely clinical in nature. Identification of the stages and progression of the disease, particularly definition of the probable MS stage, is crucial to determination of optimal treatment regimen and development of effective therapies. However, the complexities of autoimmune interactions, and the variability of MS in different individuals have made diagnosis and subsequent prognosis using traditional methods inexact and challenging. Methods for more accurate diagnosis of MS are greatly needed.  
      The profiles of MS-related genetic markers listed in Table I represent genes exhibiting differential expression in PBMCs from a large sample of MS patients, compared to that of age-matched healthy controls. Abundance of specific gene transcripts, represented by the intensity of label hybridizing to individual sequence loci of the MicroArray (Affymetrix Inc, Santa Clara Calif.), was recorded and quantified according to the manufacturers recommended protocols (such as GeneChip 3.0 software from Affymetrix). However, rather than composing the profile of differentially expressed genes based on probabilities using simple distribution of mean intensities, as has been reported by Ramanathan et al (J Immunol 2001; 116:213-219), informative genes were selected based on the degree to which they were predictive of classification of the sample as “diseased” or “not diseased”. By applying the rigorous three-pronged statistical analysis described in detail hereinbelow, 1249 genes most informative in distinguishing between diseased and otherwise not diseased patients were identified (see Table I). By applying an even more restrictive analysis of the data in Table I (see Table II, Bonfferoni analysis), a subset of the 300 highest scoring genes was identified. These MS marker genes comprise both over-expressed and downregulated genes, and represent of a diverse group of functional gene categories. Additional analysis of the markers uncovered herein also led to the identification of another restricted marker set which can be accurately utilized to diagnose probable MS patients. As is further described hereinbelow, the identification of such a marker set represents a significant breakthrough since it enables to treat individuals at a much earlier stage of MS then previously possible.  
      Thus, according to one aspect of the present invention there is provided a method of diagnosing a subject with multiple sclerosis by determining a level of expression of at least one gene of the genes listed in Tables I-V in a sample obtained from the subject, wherein a substantial difference between the level of expression of the gene in the sample obtained from the subject and a normal expression level of the gene is an indication that the subject is afflicted with multiple sclerosis.  
      Normal expression levels of a marker or markers are obtained from isolated or cultured PMBCs (e.g., T-cell cultures), or samples obtained from individuals not affected with MS. A substantial difference is preferably of a magnitude that is statistically significant (see the Examples section for more detail). In particularly preferred embodiments, the marker is increased or decreased relative to control samples by at least 2-, 3-, 4-, 5-, 6-, 7-, 8-, 9-, or 10-fold or more. Similarly, one skilled in the art will be well aware of the fact that a preferred detection methodology is one in which the resulting detection values are above the minimum detection limit of the methodology utilized.  
      As is further described in the Examples section which follows, the marker listed in Tables I-V were identified in peripheral blood cells. As such, the sample obtained from the individual is preferably a peripheral blood sample or any sample which includes blood cells such as T-cells. In a preferred embodiment, the sample is blood, thymus, spleen, lymph, pus, or bone marrow. However, it will be apparent to one skilled in the art that PMBCs may be present as an infiltrate in many other tissues, and that such tissues may also serve as samples in which the presence, activity, and/or quantity of the markers of the invention may be assessed. The tissue samples containing one or more of the markers themselves may be useful in the methods of the invention, and one skilled in the art will be well aware of methods by which such samples may be conveniently obtained, stored, preserved and processed. For further description relating to collection and processing of blood samples please see the Examples section which follows.  
      As is detailed in the Examples section below, analysis of PBMC genes differentially expressed in MS, according to the methods described herein, revealed groups of genes of specific interest in MS. Genes that are most significantly over expressed, or downregulated in MS can indicate members of pathways important to disease development or pathology. Strongly overexpressed genes, according to Tables I and II, include SLAM (signaling lymphocyte activation molecule, GenBank Accession No. U33017), LEF1 (lymphoid enhancer-binding factor 1, GenBank Accession No. AL099409), LRP5 (low density lipoprotein receptor-related protein 5, GenBank Accession No. AF077820), LILRB (leukocyte immunoglobulin-like receptor, GenBank Accession No. AF004230), LY75 (lymphocyte antigen 75, GenBank Accession No. AF011333), CDW52 (GenBank Accession No. N90866), PIP5K1-gamma (Phosphatidylinositol-4-phosphate 5-kinase, type 1, gamma, GenBank Accession No. AB011161), MAP4 (Microtubule-associated protein 4, GenBank Accession No. M64571), CTSK (Cathepsin K, GenBank Accession No. X82153) and CTSB (Cathepsin B, GenBank Accession No. L22507). Strongly down-regulated genes include IL1B (Interleukin 1 beta, GenBank Accession No. M15330), TRAF6 (GenBank Accession No. U78798), SCYA20 (GenBank Accession No. U64197), IL1R (type1 receptor, GenBank Accession No. M27492), IL1RAP (receptor accessory protein, GenBank Accession No. AB006537) and IL1RN (receptor antagonist, GenBank Accession No. X52015), TGFB1 (Transforming growth Factor beta. 1, GenBank Accession No. X05839), SKI (v-ski sarcoma viral oncogene homologue, GenBank Accession No. X15218), VEGF (Vascular endothelial growth factor, GenBank Accession No. M63978), IGFBP4 (Insulin-like growth factor binding protein 4, GenBank Accession No. U20982), EREG (epiregulin, GenBank Accession No. NM — 001432.1), and NR4A1, NR4A2, NR4A3 (nuclear receptor family genes, GenBank Accession Nos. NM — 002135.1, X75918 and U12767, respectively).  
      Functional groups of genes strongly represented in the profile of most significantly differentially regulated genes in MS include, inter alia, apoptosis-related genes, T-cell activation and expansion related genes, cell proliferation related genes and epidermal growth factor genes. Many of the marker genes identified are associated with other MS-related genes, according to Tables I-V.  
      It will be appreciated that although a single marker can be used for diagnosis, diagnostic accuracy typically increases with an increase in the number of markers utilized.  
      As such, the diagnostic method of the present invention preferably utilizes a marker set that can range anywhere from 2 genes to 1200 genes. For example, the present method can utilize at least 10, at least 50, at least 100, at least 250, at least 500, at least 750, at least 1000 or at least 1200 genes each independently selected from the group consisting of the genes listed in Tables I-V. Most preferably the markers utilized are selected from the sequences listed in Table II.  
      The markers sets utilized can be selected according to a statistical significance or fold change thereof (provided for each marker in Tables I-V), a higher significance and higher fold change indicating higher probability of marker accuracy. For example, a selected marker set can encompass markers displaying a high statistical significance (low P-value), preferably a P-value lower than 5.0E-02, more preferably lower than 5.0E-04, most preferably, lower than 5.0E-06. Alternatively, markers can be selected according to shared features of the marker gene. For example, gene markers of similar cellular function (e.g., genes of a signaling pathway such as apoptosis) or markers displaying similar activity (e.g., enzymes of the same enzyme family) can be grouped into specific marker sets.  
      Each marker set may be considered individually, although it is within the scope of the invention to provide combinations of two or more marker sets for use in the methods and compositions of the invention to increase the confidence of the analysis.  
      As used herein, the terms “polynucleotide” and “oligonucleotide” are used interchangeably, and include polymeric forms of nucleotides of any length, either deoxyribonucleotides or ribonucleotides, or analogs thereof. Polynucleotides may have any three-dimensional structure, and may perform any function, known or unknown. The following are non-limiting examples of polynucleotides: a gene or gene fragment, exons, introns, messenger RNA (mRNA), transfer RNA, ribosomal RNA, ribozymes, cDNA, recombinant polynucleotides, branched polynucleotides, plasmids, vectors, isolated DNA of any sequence, isolated RNA of any sequence, nucleic acid probes, and primers. A polynucleotide may comprise modified nucleotides, such as methylated nucleotides and nucleotide analogs. If present, modifications to the nucleotide structure may be imparted before or after assembly of the polymer. The sequence of nucleotides may be interrupted by non-nucleotide components. A polynucleotide may be further modified after polymerization, such as by conjugation with a labeling component. The term also includes both double- and single-stranded molecules. Unless otherwise specified or required, any embodiment of this invention that is a polynucleotide encompasses both the double-stranded form and each of two complementary single-stranded forms known or predicted to make up the double-stranded form.  
      As used herein, a “gene” includes a polynucleotide containing at least one open reading frame that is capable of encoding a particular polypeptide or protein after being transcribed and translated. Any of the polynucleotide sequences described herein may be used to identify larger fragments or full-length coding sequences of the gene with which they are associated. Methods of isolating larger fragment sequences are known to those of skill in the art, some of which are described herein. A “gene product” includes an amino acid (e.g., peptide or polypeptide) generated when a gene is transcribed and translated.  
      As used herein, a “probe” is defined as an oligonucleotide that is provided as a reagent to detect a target present in a sample of interest by hybridizing with the target. Usually, a probe will comprise a label or a means by which a label can be attached, either before or subsequent to the hybridization reaction. Suitable labels include, but are not limited to radioisotopes, fluorochromes, chemiluminescent compounds, dyes, and proteins, including enzymes.  
      As used herein, “expression” includes the process by which polynucleotides are transcribed into mRNA and translated into peptides, polypeptides, or proteins. “Differentially expressed”, as applied to a gene, includes the differential production of mRNA transcribed from a gene or a protein product encoded by the gene. A differentially expressed gene may be overexpressed or underexpressed as compared to the expression level of a normal or control cell. In one aspect, it includes a differential that is 2.5 times, preferably 5 times or preferably 10 times higher or lower than the expression level detected in a control sample. The term “differentially expressed” also includes nucleotide sequences in a cell or tissue which are expressed where silent in a control cell or not expressed where expressed in a control cell.  
      As used herein, the term “polypeptide” is defined as a compound of two or more subunit amino acids, amino acid analogs, or peptidomimetics. The subunits may be linked by peptide bonds. In another embodiment, the subunit may be linked by other bonds, e.g., ester, ether, etc. As used herein the term “amino acid” includes either natural and/or unnatural or synthetic amino acids, including glycine and both the D or L optical isomers, and amino acid analogs and peptidomimetics. A peptide of three or more amino acids is commonly referred to as an oligopeptide. Peptide chains of greater than three or more amino acids are referred to as a polypeptide or a protein.  
      As used herein, the term “marker” is defined as a polynucleotide or polypeptide molecule which is present or absent, or increased or decreased in quantity or activity in subjects afflicted with multiple sclerosis, or in cells involved in multiple sclerosis. The relative change in quantity or activity of the marker is correlated with the incidence or risk of incidence of multiple sclerosis or progression from one stage of the disease to another.  
      Although all of the markers listed in Tables I-V can be used in diagnosis of MS, an additional object of the present invention was to identify those markers which can be utilized to diagnose specific clinical forms and/or stages of MS.  
      Accurate clinical tools for specific diagnosis of disease stages in MS are presently unavailable.  
      As a result of comprehensive studies conducted in efforts to evaluate specific gene expression in relation to clinical disease phases, the present invention provides, for the first time, specific markers sets which can be utilized in accurate diagnosis of specific forms and stages of MS  
      As is illustrated in Example II of the Examples section which follows, the present invention provides marker sets which can be accurately utilized to diagnose acute relapse, remission and probable stages of MS (Tables III-V).  
      Of particular importance is the marker set provided in Table V. As is described in the Examples section which follows, the present inventors also uncovered cellular markers which distinct between disease-related and non-disease related T-cell myelin reactivity. Although MS appears to be caused by autoimmune T-cells activated against myelin self-antigens, myelin-reactive T-cells have been demonstrated in healthy subjects as well. Thus, distinction between disease-related and non-disease related T-cell myelin reactivity is of great clinical and investigational importance.  
      Cellular markers which distinct between disease-related and non-disease related T-cell myelin reactivity include down-regulating apoptosis associated genes, up regulating anti-apoptotic genes and genes responsible for increased expansion capability of autoreactive T cells and enhanced ability to penetrate the CNS. Thus, the markers of Table V include genes involved in perpetuating pathologic cellular proliferation and tissue destruction within the CNS characteristic of MS, along with increased resistance to regulation. This marker set accurately defines the requirements for an individual to develop MS, and thus has important predictive value, especially in diagnosing individuals having MS in the “probable” stage.  
      The identification of these markers significantly advances the field of MS diagnosis and treatment as well as provides tools which will enable elucidation of the mechanisms underlying MS formation and progression, ultimately leading to formulation of efficient, stage specific, treatment regimens.  
      The markers of the invention may be nucleic acid molecules (e.g., DNA, cDNA, or RNA) or the polypeptides encoded thereby. As such, detection of markers in a sample obtained from an individual can be effected using various detection methods well known to the ordinary skilled artisan.  
      Briefly, measurement of the relative amount of nucleic acid or polypeptide molecules can be effected by any method known in the art (see, e.g., Sambrook, J., Fritsh, E. F., and Maniatis, T. Molecular Cloning: A Laboratory Manual. 2nd, ed, Cold Spring Harbor Laboratory, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y., 1989; and Current Protocols in Molecular Biology, eds. Ausubel et al. John Wiley &amp; Sons: 1992). Typical methodologies for RNA detection include RNA extraction from a cell or tissue sample, followed by hybridization of a labeled probe (e.g., a complementary nucleic acid molecule) specific for the target RNA to the extracted RNA, and detection of the probe (e.g., Northern blotting). Typical methodologies for polypeptide detection include activity assays in cases of known enzymes, protein extraction from a cell or tissue sample, followed by hybridization of a labeled probe (e.g., an antibody) specific for the target protein to the protein sample, and detection of the probe. The label group can be a radioisotope, a fluorescent compound, an enzyme, or an enzyme co-factor. Detection of specific polypeptide and nucleic acid molecules may also be assessed by gel electrophoresis, column chromatography, direct sequencing, or quantitative PCR (in the case of nucleic acid molecules) among many other techniques well known to those skilled in the art.  
      Probes based on the nucleotide sequence of a marker gene or of a nucleic acid molecule encoding a marker polypeptide of the invention can be used to detect transcripts or genomic sequences corresponding to the marker gene(s) and/or marker polypeptide(s) of the invention. In preferred embodiments, the probe comprises a label group attached thereto, e.g., the label group can be a radioisotope, a fluorescent compound, an enzyme, or an enzyme co-factor. Such probes can be used as a part of a diagnostic test kit for identifying cells or tissue which misexpress (e.g., over- or under-express) a marker polypeptide of the invention, or which have greater or fewer copies of a marker gene of the invention. For example, a level of a marker polypeptide-encoding nucleic acid in a sample of cells from a subject may be detected, the amount of mRNA transcript of a gene encoding a marker polypeptide may be determined, or the presence of mutations or deletions of a marker gene of the invention may be assessed. The invention further encompasses nucleic acid molecules that differ from the nucleic acid sequences of the genes set forth in Tables I-V, due to degeneracy of the genetic code and which thus encode the same proteins as those encoded by the genes shown in Tables I-V.  
      An isolated marker protein, or a portion or fragment thereof, can be used as an immunogen to generate antibodies that bind marker proteins using standard techniques for polyclonal and monoclonal antibody preparation. A full-length marker protein can be used or, alternatively, the invention provides antigenic peptide fragments of these proteins for use as immunogens. The antigenic peptide of a marker protein comprises at least 8 amino acid residues of an amino acid sequence encoded by a gene set forth in Tables I-V, and encompasses an epitope of a marker protein such that an antibody raised against the peptide forms a specific immune complex with the marker protein. Preferably, the antigenic peptide comprises at least 10 amino acid residues, more preferably at least 15 amino acid residues, even more preferably at least 20 amino acid residues, and most preferably at least 30 amino acid residues. Preferred epitopes encompassed by the antigenic peptide are regions of the marker protein that are located on the surface of the protein, e.g., hydrophilic regions, as well as regions with high antigenicity.  
      An anti-marker protein antibody (e.g., monoclonal antibody) can be used to isolate a marker protein of the invention by standard techniques, such as affinity chromatography or immunoprecipitation. An anti-marker protein antibody can facilitate the purification of natural marker proteins from cells and of recombinantly produced marker proteins expressed in host cells. Moreover, an anti-marker protein antibody can be used to detect marker protein (e.g., in a cellular lysate or cell supernatant) in order to evaluate the abundance and pattern of expression of the marker protein. Anti-marker protein antibodies can be used diagnostically to monitor protein levels in tissue as part of a clinical testing procedure, e.g., to, for example, determine the efficacy of a given treatment regimen. Detection can be facilitated by coupling (i.e., physically linking) the antibody to a detectable substance. Examples of detectable substances include various enzymes, prosthetic groups, fluorescent materials, luminescent materials, bioluminescent materials, and radioactive materials. Examples of suitable enzymes include horseradish peroxidase, alkaline phosphatase, -galactosidase, or acetylcholinesterase; examples of suitable prosthetic group complexes include streptavidin/biotin and avidin/biotin; examples of suitable fluorescent materials include umbelliferone, fluorescein, fluorescein isothiocyanate, rhodamine, dichlorotriazinylamine fluorescein, dansyl chloride or phycoerythrin; an example of a luminescent material includes luminol; examples of bioluminescent materials include luciferase, luciferin, and aequorin, and examples of suitable radioactive material include  125 I,  131 I,  35 S or  3 H.  
      The nucleic acid and protein sequences of the present invention can further be used as a “query sequence” to perform a search against public databases to, for example, identify other family members or related sequences. Such searches can be performed using the NBLAST and XBLAST programs (version 2.0) of Altschul, et al. (J. Mol. Biol. 1990; 215:403-10). BLAST nucleotide searches can be performed with the NBLAST program, score=100, wordlength=12 to obtain nucleotide sequences homologous to nucleic acid molecules of the invention. BLAST protein searches can be performed with the XBLAST program, score=50, wordlength=3 to obtain amino acid sequences homologous to marker protein molecules of the invention. To obtain gapped alignments for comparison purposes, Gapped BLAST can be utilized as described in Altschul et al., (1997) Nucleic Acids Res. 25(17):3389-3402. When utilizing BLAST and Gapped BLAST programs, the default parameters of the respective programs (e.g., XBLAST and NBLAST) can be used. See http://www.ncbi.nlm.nih.gov.  
      It will be appreciated that non-coding sequences, such as promoter or other regulatory sequences of marker genes may be used as probes in the context of the present invention. Thus, the expression of groups of functionally related genes, responsive to similar signals important to the pathogenesis or progression of multiple sclerosis, may be assessed.  
      It will be appreciated that in certain cases the genes themselves can serve as markers. For example, mutations in the nucleic acid sequence of a gene (e.g., non-sense, mis-sense deletion and the like) which result in lower expression levels of the gene or lower activity of the gene product may be correlated with MS. Similarly, a duplication of the gene, which can result in higher expression levels or mutations which result in higher activity can also be correlated with MS.  
      Detection of the presence or number of copies of all or a part of a marker gene of the invention may be performed using any method known in the art. Typically, it is convenient to assess the presence, quantity and quality of genomic DNA by Southern analysis, in which total DNA from a cell or tissue sample is extracted, is hybridized with a labeled probe (e.g., a complementary DNA molecule), and the probe is detected. The label group can be a radioisotope, a fluorescent compound, an enzyme, or an enzyme co-factor. Other useful methods of DNA detection and/or quantification include direct sequencing, gel electrophoresis, column chromatography, and quantitative PCR, as is known by one skilled in the art.  
      In cases where detection involves discrete marker sets, the detection method of the present invention preferably employs marker probes which are conjugated to a solid support. For example, polynucleotide probes capable of specifically hybridizing with polynucleotide markers of the present invention (e.g., mRNA) may be coupled to an array (e.g., a GeneChip array for hybridization analysis), to a resin (e.g., a resin which can be packed into a column for column chromatography), or a matrix (e.g., a nitrocellulose matrix for northern blot analysis). The immobilization of molecules complementary to the marker(s), either covalently or noncovalently, permits a discrete analysis of the presence or activity of each marker in a sample. In an array, for example, polynucleotides complementary to each member of a marker set may individually be attached to different, known locations on the array (region-specific arrays). The array may be hybridized with, for example, polynucleotides extracted from a blood sample obtained from a subject. The hybridization of polynucleotides extracted from the sample with the array at any location on the array can be detected, and thus the presence or quantity of the marker in the sample can be ascertained. In a preferred embodiment, a “GeneChip” array is employed (e.g., an Affymetrix type array). Similarly, Western analyses may be performed on immobilized antibodies specific for different polypeptide markers hybridized to a protein sample from a subject.  
      It will also be apparent to one skilled in the art that the probes of the array need not bind with the entire marker molecule. A probe designed to bind a portion of the marker of sufficient length for detection purposes (e.g., for hybridization), for example, a portion of the marker which is 7, 10, 15, 20, 25, 30, 35, 40, 45, 50, 55, 60, 65, 70, 75, 100 or more nucleotides or amino acids in length may be sufficient for detection purposes.  
      Polynucleotide probes can be synthesized using any known synthesis method. Preferably, synthesis is effected using on-chip lithography methodology in a manner similar to that utilized for the synthesis of Affymetrix chips (www.affymetrix.com). Additional methods of array production and methodology are described in detail in the U.S. patent applications cited in the Background section hereinabove.  
      Antibody probes useful for detecting polypeptide markers can be generated using various well known techniques. For example, monoclonal antibodies which can be used per se or as a basis for antibody fragments (scFv, Fab etc) can be synthesized using isolated Hybridomas. In such an approach, a protein corresponding to a marker of the invention is isolated (e.g., by purification from a cell in which it is expressed or by transcription and translation of a nucleic acid encoding the protein in vivo or in vitro using known methods. A vertebrate, preferably a mammal such as a mouse, rat, rabbit, or sheep, is immunized using the isolated protein or protein fragment. The vertebrate may optionally (and preferably) be immunized at least one additional time with the isolated protein or protein fragment, so that the vertebrate exhibits a robust immune response to the protein or protein fragment. Splenocytes are isolated from the immunized vertebrate and fused with an immortalized cell line to form hybridomas, using any of a variety of methods well known in the art. Hybridomas formed in this manner are then screened using standard methods to identify one or more hybridomas which produce an antibody which specifically binds with the protein or protein fragment.  
      The invention also includes an array comprising a marker(s) of the present invention. The array can be used to assay expression of one or more genes in the array.  
      In one embodiment, the array can be used to assay gene expression in a tissue of multiple sclerosis patients at different stages of the disease to ascertain stage specificity of genes in the array. In this manner, more than about 30,000 genes can be simultaneously assayed for expression. This allows a profile to be developed showing a battery of genes specifically expressed in one or more stages of the disease.  
      In addition to such qualitative determination, the invention allows the quantitation of gene expression. Thus, not only stage specificity, but also the level of expression of a battery of stage specific genes is ascertainable. Thus, genes can be grouped on the basis of their expression per se, and level of expression in that stage of the disease.  
      The detection arrays described herein are preferably packaged in kits identified for use in detecting MS in general or for detecting specific stages of MS. The kit can further include reagents suitable for the detection of polynucleotide hybridization or antibody binding and instructions for effecting diagnosis using the kit components and suitable detection hardware (e.g., detection microscope) and software (e.g., detection and analysis software). For further description of such hardware and software and detection reagents please see www.affymetrix.com.  
      Thus, the present invention provides methods useful for diagnosing MS including specific stages or states of the disease and also a risk of developing the disease.  
      These methods involve isolating a sample from a subject (e.g., a sample containing T-cells), detecting the presence, quantity, and/or activity of one or more markers of the invention in the sample relative to a normal sample. Observing a significant increase or decrease in one or more markers in the test sample indicates the presence or risk of presence of MS.  
      Using specific marker sets, the present invention also provides methods of assessing the severity or stage of MS in a subject.  
      As detailed hereinabove, a major concern in treatment of multiple sclerosis is accurate early diagnosis following the first acute attack. At present, clinical studies indicate that only 40-50% of individuals suffering a first acute attack will progress to clinically definite MS. Thus, treatment protocols most commonly suspend treatment of these patients defined as probable MS, until the appearance of a second attack, which may entail years of waiting and uncertainty. It will be appreciated that early and accurate detection of the portion of probable MS patients likely to progress to further stages of the disease can save undue suffering and expense, and, more importantly, provide early treatment and a better prognosis for the portion of probable MS patients likely to progress to more severe stages. The present invention provides, for the first time, marker genes for probable MS, as well as for relapsing vs. remitting MS.  
      The present invention also provides methodology which can be used to assess the efficacy of an MS treatment regimen and/or the effect of environmental factors or diet on the progression of MS.  
      These methods involve isolating a sample from a subject (e.g., a sample containing T-cells) suffering from MS who is undergoing treatment which includes drug therapy, exposure to a predetermined environmental condition and/or a specific diet, detecting the presence, quantity, and/or activity of one or more markers of the invention in test samples obtained from the subject prior to and following treatment or in a test sample obtained from the subject relative to a sample obtained from an individual suffering from MS who is not undergoing any treatment and/or relative to a sample obtained from an individual not suffering from MS and undergoing treatment. The levels of markers in the samples are compared, and significant increases or decreases in one or more markers in the test sample following treatment relative to the other samples are observed, and correlated with the severity or stage of MS. By assessing whether MS has been lessened or alleviated, the ability of the treatment or therapy to treat MS is also determined.  
      It will be appreciated that the present invention also provides methods of treating (e.g., inhibiting) the formation or progression of MS. These methods involve isolating a sample from a subject (e.g., a sample containing PMBCs such as T-cells), detecting the presence, quantity, and/or activity of one or more markers of the invention in the sample relative to a normal sample and observing significant increases or decreases in one or more markers in the test sample. For markers that are significantly decreased in expression or activity, the subject may be administered that expressed marker protein, or may be treated by the introduction of mRNA or DNA corresponding to the decreased marker (e.g., by gene therapy), to thereby increase the levels of the marker protein in the subject. For markers that are significantly increased in expression or activity, the subject may be administered mRNA or DNA antisense to the increased marker (e.g., by gene therapy), or may be administered antibodies specific for the marker protein, to thereby decrease the levels of the marker protein in the subject. In this manner, the subject may be treated for MS or MS related condition.  
      In another embodiment, the methods further involve obtaining a control biological sample (e.g., nondiseased tissue) from a control subject, contacting the control sample with a compound or agent capable of detecting marker protein, mRNA, or genomic DNA, such that the presence of marker protein, mRNA or genomic DNA is detected in the biological sample, and comparing the presence of marker protein, mRNA or genomic DNA in the control sample with the presence of marker protein, mRNA or genomic DNA in the test sample.  
      The invention also provides methods for identifying modulators, i.e., candidate or test compounds or agents (e.g., peptides, peptidomimetics, peptoids, small molecules or other drugs) which (a) bind to the marker, or (b) have a modulatory (e.g., stimulatory or inhibitory) effect on the activity of the marker or, more specifically, (c) have a modulatory effect on the interactions of the marker with one or more of its natural substrates (e.g., peptide, protein, hormone, co-factor, or nucleic acid), or (d) have a modulatory effect on the expression of the marker. Such assays typically comprise a reaction between the marker and one or more assay components. The other components may be either the test compound itself, or a combination of test compound and a natural binding partner of the marker. The test compounds of the present invention may be obtained from any available source, including systematic libraries of natural and/or synthetic compounds. Test compounds may also be obtained by any of the numerous approaches in combinatorial library methods known in the art, including: biological libraries; peptoid libraries (libraries of molecules having the functionalities of peptides, but with a novel, non-peptide backbone which are resistant to enzymatic degradation but which nevertheless remain bioactive; (see, e.g., Zuckermann et al., 1994, J. Med. Chem. 37:2678-85); spatially addressable parallel solid phase or solution phase libraries; synthetic library methods requiring deconvolution; the ‘one-bead one-compound’ library method; and synthetic library methods using affinity chromatography selection. The biological library and peptoid library approaches are limited to peptide libraries, while the other four approaches are applicable to peptide, non-peptide oligomer or small molecule libraries of compounds (Lam, 1997, Anticancer Drug Des. 12:145).  
      Additional objects, advantages, and novel features of the present invention will become apparent to one ordinarily skilled in the art upon examination of the following examples, which are not intended to be limiting. Additionally, each of the various embodiments and aspects of the present invention as delineated hereinabove and as claimed in the claims section below finds experimental support in the following examples.  
     EXAMPLES  
      Reference is now made to the following examples, which together with the above descriptions, illustrate the invention in a non limiting fashion.  
      Generally, the nomenclature used herein and the laboratory procedures utilized in the present invention include molecular, biochemical, microbiological and recombinant DNA techniques. Such techniques are thoroughly explained in the literature. See, for example, “Molecular Cloning: A laboratory Manual” Sambrook et al., (1989); “Current Protocols in Molecular Biology” Volumes I-III Ausubel, R. M., ed. (1994); Ausubel et al., “Current Protocols in Molecular Biology”, John Wiley and Sons, Baltimore, Md. (1989); Perbal, “A Practical Guide to Molecular Cloning”, John Wiley &amp; Sons, New York (1988); Watson et al., “Recombinant DNA”, Scientific American Books, New York; Birren et al. (eds) “Genome Analysis: A Laboratory Manual Series”, Vols. 1-4, Cold Spring Harbor Laboratory Press, New York (1998); methodologies as set forth in U.S. Pat. Nos. 4,666,828; 4,683,202; 4,801,531; 5,192,659 and 5,272,057; “Cell Biology: A Laboratory Handbook”, Volumes I-III Cellis, J. E., ed. (1994); “Culture of Animal Cells—A Manual of Basic Technique” by Freshney, Wiley-Liss, N.Y. (1994), Third Edition; “Current Protocols in Immunology” Volumes I-III Coligan J. E., ed. (1994); Stites et al. (eds), “Basic and Clinical Immunology” (8th Edition), Appleton &amp; Lange, Norwalk, Conn. (1994); Mishell and Shiigi (eds), “Selected Methods in Cellular Immunology”, W. H. Freeman and Co., New York (1980); available immunoassays are extensively described in the patent and scientific literature, see, for example, U.S. Pat. Nos. 3,791,932; 3,839,153; 3,850,752; 3,850,578; 3,853,987; 3,867,517; 3,879,262; 3,901,654; 3,935,074; 3,984,533; 3,996,345; 4,034,074; 4,098,876; 4,879,219; 5,011,771 and 5,281,521; “Oligonucleotide Synthesis” Gait, M. J., ed. (1984); “Nucleic Acid Hybridization” Hames, B. D., and Higgins S. J., eds. (1985); “Transcription and Translation” Hames, B. D., and Higgins S. J., eds. (1984); “Animal Cell Culture” Freshney, R. I., ed. (1986); “Immobilized Cells and Enzymes” IRL Press, (1986); “A Practical Guide to Molecular Cloning” Perbal, B., (1984) and “Methods in Enzymology” Vol. 1-317, Academic Press; “PCR Protocols: A Guide To Methods And Applications”, Academic Press, San Diego, Calif. (1990); Marshak et al., “Strategies for Protein Purification and Characterization—A Laboratory Course Manual” CSHL Press (1996); all of which are incorporated by reference as if fully set forth herein. Other general references are provided throughout this document. The procedures therein are believed to be well known in the art and are provided for the convenience of the reader. All the information contained therein is incorporated herein by reference.  
     Materials and Methods  
      Subjects—Blood was obtained from patients or controls after written informed consent. For comparison of healthy controls and MS patients, and between MS patients in acute relapse or remission: Gene expression profiles of 26 patients (20 females, mean age 41.0±2.5 years) with definite diagnosis of MS according to Poser criteria (8), a relapsing-remitting disease course, and brain magnetic resonance imaging ascertaining the diagnosis (9) were compared with eighteen (18) age-matched healthy subjects (16 females). For comparison of transcriptional profiles in MOG-reactive T-cells: Four MS female patients (mean age 38±4.2 years, mean disease duration 9.3±3.3 years) having a definite MS according to Poser criteria (10), a relapsing-remitting disease course, neurological disability evaluated by the expanded disability status scale (EDSS, 11) between 2 to 5.0, and brain MRI supporting the diagnosis of MS, and three age- and sex-matched healthy controls were included in the study. None of the patients received immunomodulatory drugs or steroid treatment for at least three months prior to when blood was drawn. The studies were approved by the institutional review board and the Israel Ministry of Health.  
      mRNA preparation—Total RNA was isolated from Ficoll™ isolated Peripheral Blood. Mononuclear Cells (PBMC) or from MOG-stimulated T cell lines (2×10 7  cells) by ice-cold TRIZOL Reagent (Gibco, BRL). Poly-A mRNA was isolated using a mini-kit (Oligotex, Qiagen) and used as a template for double-stranded cDNA synthesis using oligo (dT)-24 primers containing a T7 RNA polymerase promoter site added to the 3′-end (Genset). After phenol/chloroform extraction cDNA was used as a template for in vitro transcription (Ambion T7 Megascript system) with biotin labeled nucleotides (Enzo Diagnostics). Labeled cRNA was fragmented, quantified by spectrophotometer, and hybridized to the microarrays.  
      Microarray gene analysis—Each Genechip (U95Av2) which carries probes for 12,625 (or U133A with 22,000 for patients with probable MS diagnosis) transcripts was hybridized with 10 μg/200 μl hybridization mix, stained and scanned (Hewlett Packard, GeneArray™ scanner G2500A) according to manufacturer protocol (Affymetrix Inc, Santa Clara, Calif.). Scaling procedure was performed to an average intensity of 600 per gene. A value of 20 was assigned to all measurements lower then 20. For comparison of healthy controls and MS patients, and between MS patients in acute relapse or remission: All data was normalized by dChip software and fold ratios were calculated for each gene of the samples against geometric means of the matched controls. For comparison of transcriptional profiles in MOG-reactive T-cells: Genes that did not have at least one average difference intensity value≧100 or were present at least once by Affymetrix criteria, were not included in the analysis.  
      Data analysis—The analysis was performed according to the analytical approach as previously described (24-26). Genechip 4 software (Affymetrix Inc, Santa Clara, Calif.) was used for analysis of the scanned arrays. Fold ratios were calculated for each gene of the samples against the geometric mean of matched controls. For comparison of transcriptional profiles in MOG-reactive T-cells: To determine the most informative genes threshold number of misclassifications (TNoM) score was applied. This score counts the number of classification errors that occur between compared groups for each gene of the dataset. The best threshold (TNoM=0) implies that no errors have been counted and the distinction between the two groups in relation to the expression level of a specific gene is maximal. To select a group of strongly differential expression, t-test p-value (comparing expression levels of genes from MS patients vs. healthy controls) were also computed. Genes with TNoM=0, fold-change&gt;1.5 (either up or down regulated) and corresponded t-test P value&lt;0.05, were designated as most informative. For comparison of healthy controls and MS patients, and between MS patients in acute relapse or remission: The data was analyzed by the classic parametric t-test, and the following non-parametric tests: (i) Threshold number of misclassifications (TNoM) method and (ii) INFO score that measures the misclassifications made by a simple threshold in terms of the information lost. Analysis was performed between MS patients and the control group for each gene of the dataset as well as between subgroups of patients. Only informative MS related genes (p&lt;0.05 in all three statistical tests) were included. To retrieve the most informative genes, the False Discovery Rate (FDR) method (14) that ranks and tests all “P” values against different thresholds was used. The degree of significance by the Bonferroni threshold method, which evaluates the allowed error probability divided by the number of genes measured, and ensures that each and every validated scoring event is indeed a significant event, was also calculated.  
      Validation Strategy—To further assess the predictive power of the data sets, computerized analysis by the Leave-One-Out-Cross-Validation (LOOCV) statistical method was performed. The method simulates removal of a single sample every trial and trains on the rest. The procedure is repeated until each sample is left out once and the number of correct and incorrect predictions is counted.  
     Example I  
     Accurate Gene Expression Profiles of MS  
      In order to provide an accurate, reliable profile of gene markers for diagnosis and evaluation of MS, DNA chip analysis was used to compare multiple gene expression patterns of PBMCs from patients with different clinical forms of MS. After informed consent blood was obtained from 26 patients (20 females, mean age 41.0±2.5 years) with definite diagnosis of MS according to Poser criteria, a relapsing-remitting disease course, and brain magnetic resonance imaging ascertaining the diagnosis. Eighteen age-matched healthy subjects (16 females) served as controls. PBMC gene expression of 12,625 human genes was analyzed as described hereinabove, using Ficoll™ for preparation of PBMCs and total RNA purification and sample preparation according to the instructions of Affymetrix, Inc (Affymetrix, Santa Clara Calif., USA). In order to determine the most informative genes, unique computerized scoring methods, as yet not applied to analysis of data regarding MS, were employed. In brief, a gene is designated as informative based on the degree to which its tissue expression level is predictive of an independent classification of the tissue sample as “diseased” or “not diseased”, as previously described by Ben-Dor et al (J Comput Biol 2000; 7:559-63) and applied to the analysis of breast cancer and melanoma using cDNA arrays (for review see Freidman N et al Ernst Schering Res Found Wkshp 2002; 38:109-31). The scores used in this study were:  
      TNoM (Total Number of Misclassifications)—the number of classification errors committed when using the best simple threshold to distinguish between two classes (diseased or not diseased) based on the expression levels of a specific gene.  
      INFO—an estimate of the uncertainty remaining about accuracy of a sample classification (diseased or not diseased) after the incorporation of predictions based on expression of an individual gene is given (a lower “INFO” score indicates a higher predictive value for a given gene).  
      Gaussian (t-test)—The overlap between distributions of expression levels for genes in two classes. The score is based on normality assumptions.  
      One of the advantages of the analytic methods used here is their amenability to rigorous statistical benchmarking. Using this unique analysis, the number of informative genes per score expected in a random classification can be calculated, and then this estimated number of high scoring (or informative) genes can be compared to the actual number of informative genes (per score) measured in a dataset.  
      Comparison of the gene expression profiles shows that gene expression of PBMC in MS patients is significantly different from that in healthy subjects. Under the null-hypotheses that the separation of the samples is random despite genetic heterogeneity between tested groups, observed significant overabundance of informative genes was observed ( FIG. 1A ). The difference between expected and observed number of genes with significant p value in all 3 statistical tests (t-test, TNoM, INFO) performed, indicates that the diversity in gene expression observed in PBMC is biologically significant.  
      The predictive power of the data sets results was assessed by performing computerized error estimates based on leave-one-out cross validation (LOOCV) trials. The results disclosed only 3 classification errors. This low rate of error estimates suggest that the gene expression signature in MS is reliable for the diagnosis of the disease using peripheral blood and confirms that the patterns we observed accurately represent significant biologic phenomena associated with MS. The false discovery rate (FDR) method distinguished 1249 most informative genes that pass 95% FDR on all three statistical tests (t-test, TNoM, INFO) at p&lt;0.05 ( FIG. 1B  and Table I).  
      Confirmation of gene microarray expression findings was performed by RT-PCR for the following five randomly selected genes: EGFL5, P44, GS3686, MX1 and CCR2. Significant correlations (coefficients ranged from 0.76 to 0.98) were found between the relative number of expression genes analysis and the RT-PCR profile. The data from microarray hybridizations was further tested against the strict Bonferroni threshold method from all three statistical tests, as described hereinabove, resulting in 300 top scoring genes that distinguish between MS and healthy subjects. (Table II).  
      The 1249 most informative genes (681 up-regulated, 569 down-regulated, Table I) consist of inflammatory, apoptosis and cell signaling pathways components, cytokines, antigen presentation molecules and chemokines as well as number of expressed sequence tags (ESTs).  
      Over-expressed genes in MS—The most abundant over-expressed transcripts unique to MS include: (i) SLAM (signaling lymphocyte activation molecule) a member of the immunoglobulin gene superfamily that is involved in T-cell stimulation. SLAM potentiates T-cell expansion and was described as CD28 independent co-stimulatory molecule, selectively increasing interferon gamma production and dysregulating type 1 and type 2 cytokine production in MS upon T-cell receptor activation. The surprising observation of SLAM upregulation suggests an enhanced proliferation of autoreactive T cells in MS patients; (ii) LEF1 (lymphoid enhancer-binding factor 1) one of the transcriptional factors expressed in pre-B and T cells, and known to be associated with T cell receptor (TCR) stimulation and apoptosis survival of pro-B cells (19); (iii) LRP5 (low density lipoprotein receptor-related protein 5) a of cell receptor protein required for LEF1 activation; (iv) LILRB (leukocyte immunoglobulin-like receptor), a protein that binds MHC class I molecules and delivers a negative signal inhibiting killing by natural killer and regulatory T cells; (v) LY75 (lymphocyte antigen 75) an endocytotic receptor used by dendritic cells to direct captured antigens from the extracellular space to a specialized antigen-processing compartment; and (vi) CDW52, a 21-28 kDa glycopeptide antigen expressed on lymphocytes and macrophages known to be a target for complement-mediated insult, inducing pro-inflammatory cytokine (e.g. TNF alpha and interferon gamma) production. Other up-regulated genes are members of the anti-apoptotic pathways, and include PIP5K1-gamma (Phosphatidylinositol-4-phosphate 5-kinase, type 1, gamma) and MAP4 (Microtubule-associated protein 4). Over-expression of transcripts belonging to the papain cysteine proteinase family CTSK (Cathepsin K) and CTSB (Cathepsin B) was also observed.  
      Down-regulated genes in MS—Abundant down-regulated transcripts unique to MS that were identified include IL1B (Interleukin 1 beta), an important inflammatory cytokine; TRAF6, which is essential for IL1 signaling; and SCYA20, known to be mediated by IL1B. Decreased mRNA expression of IL1B was strengthened by the down regulation of IL1R (type1 receptor), IL1RAP (receptor accessory protein) and IL1RN (receptor antagonist).  
      Other important down-regulated genes include TGFB1 (Transforming growth Factor beta 1) and SKI (v-ski sarcoma viral oncogene homologue) a component of TGFB signaling pathway, both known to inhibit cell proliferation. Thus, their under expression may contribute to autoreactive T cell expansion. Members of epidermal growth factor family such as VEGF (Vascular endothelial growth factor), IGFBP4 (Insulin-like growth factor binding protein 4) and EREG (epiregulin) were also down regulated. Additionally, mRNA expression of members of the steroid-thyroid receptors family including nuclear receptor subfamily 4, group A members 1, 2 and 3 (NR4A1, NR4A2, NR4A3) were significantly reduced. Down regulation of these genes may inhibit apoptosis through Fas ligand and tumor necrosis factor alpha or through early response of T-cell receptor induced apoptosis of thymocytes, thus mimicking positive selection.  
      Taken together, the identification of profiles of up- (overexpressed) and down regulated genes specific to MS indicates the suitability of the methods of the present invention for identifying validated and significant molecular signatures of PBMC gene expression in MS. While reducing the present invention to practice, it was observed that the specific disease related genes include transcripts involved in T cell activation and expansion and anti-apoptotic mediators, indicating failure of apoptosis-related elimination of autoreactive T cells.  
     Example II  
     Stage Specific Gene Expression Profiles of MS  
      Accurate clinical tools for specific diagnosis of disease stages in MS are presently unavailable. In order to provide a useful profile of the clinically defined stages of MS, specific gene expression was evaluated in relation to clinical disease phases. Significant overabundance was found between the number of observed and expected genes expressed in MS patients during an acute relapse and in remission ( FIG. 2A ). Using the methods described hereinabove, the 743 most informative genes (302 up-regulated and 441 down-regulated) with p-value&lt;0.05 in all three scores (t-test, TNoM, INFO) that differentiated relapse from remission ( FIG. 2B , Table III) were identified.  
      Over-expressed genes in acute relapse of MS, compared to patients in remission—The most informative over-expressed genes included CTSL (Lysosomal cystein protease L, cathepsin L) known to play a role in MHC class II antigen presentation, responsible for quantitative and qualitative difference in peptide repertoires displayed by MHC class II molecules, and having a regulatory role in epitope generation for antigens subsets. Moreover, in vitro, proteolytic CTSL processed myelin basic protein into more then 60 different 20-40-mers species, and myelin-associated glycoprotein was described as a substrate for CTSL like proteases. These data, taken together with our observation that CTSL mRNA was over expressed in the active stage of MS, offer a biochemical basis for the immunodominant epitope spreading implicated in the pathogenesis of MS. Also up-regulated is SCYA2 (Monocyte specific chemoattractant protein, MCP1), essential for monocyte and NK cells recruitment to site of inflammatory injury. Augmented SCYA2 expression level in the CNS has been identified at the onset of EAE. Other abundant up-regulated transcripts identified by the method of the present invention include CD79A, DDIT3 (DNA-damage inducible transcript 3); E2-EPF (Ubiquitin carrier protein) and COX6.  
      Downregulated genes in acute relapse of MS, compared to patients in remission—From the downregulated gene transcripts in acute relapse vs. remission it is important to note several programmed cell death-related genes like CCNG1 (Cyclin G1) identified as p53 dependent apoptosis; PDCD2 (Programmed cell death 2) expressed in immature thymocytes; and CTLA1 (Cytotoxic T lymphocyte associated serine esterase 1), crucial for the rapid induction of apoptosis by cytotoxic cells. Also prominently down-regulated during acute relapse was JAK1 (Janus kinase 1), a protein tyrosine kinase reported to be obligatory for several cytokines receptors, important for regulation of acute cellular response.  
      The results of the functional annotation of the transcriptional motifs that distinguish between acute MS relapse and remission suggest that many of the genes are involved in cellular recruitment and epitope spreading, as well as important to immunologic mechanisms related to escape from regulatory surveillance and augmentation of cell survival potential. Thus, it can be suggested that during the acute inflammatory process of the disease there is a failure of the immune regulatory cells to inhibit autoreactivity and the self-expansion of the non-restrained autoreactive T cells further lead to a vicious cycle of on going inflammatory activity.  
      It is evident from the gene-clustering map ( FIG. 2B ) that during an acute relapse no significant differences are found between relapse treated vs. relapse untreated patients. Such a result is of great clinical significance, since this may indicate that during an acute MS exacerbation the major gene expression transcripts are related to relapse associated genes and the effect of therapy is negligible. However, during remission treatment effect was more pronounced and this effect on gene suppression in treated patients was evident.  
      Of even greater significance is the demonstration, for the first time, of a specific gene expression profile of the “probable” stage of MS. As described hereinabove, “probable” MS precedes definitive clinical diagnosis, and is characterized by diverse neurological symptoms including unilateral loss of vision, true vertigo, ataxia, paresthesia, incontinence, diplopia, dysarthria or paralysis. Probable MS patients may suffer undiagnosed for years. In order to provide a method for accurate diagnosis of probable MS, in advance of onset of clinical symptoms, gene expression in PBMC samples of 13 probable MS patients were compared with that of samples from 5 age-matched healthy controls. RNA preparation, hybridization to MicroArray and analysis of results was performed as described for Examples 1 and 2, and in the Material and Methods section hereinabove.  
      As is shown in Table V, a specific “probable” MS profile of gene expression distinguishes PBMCs of diseased and healthy individuals.  
      Thus, there is demonstrated, for the first time, gene expression profiles providing criteria for distinguishing between stages of MS in humans, for example, between relapsing and remitting MS, probable MS and healthy individuals. Further, the groups of up- and down-regulated genes identified herein may be used for investigation of mechanisms of disease and disease progression in MS.  
     Example III  
     Gene Expression Profiles in Treatment of MS  
      The effect of immunomodulatory treatment on gene expression in MS patients was investigated by comparison analysis of gene transcripts between treated and untreated patients. Suprisingly, despite the variety of immunomodulatory treatments and differences between patients in relation to treatment duration, the microarray methods described herein, treatment-related gene transcripts that differentiated between treated and untreated patients were detected. Treatment-specific gene expression is mainly associated with phosphorylation and signal transduction. Thus, gene microarray technology can be a powerful tool in evaluating and monitoring clinical correlations of effects of treatment, and determining prognosis.  
      Thus, data presented herein demonstrate for the first time distinct and significant fingerprint cluster in MS patients that differentiates them from healthy subjects. Moreover, the stringent and specific fingerprint is predictive for the diagnosis of MS and is suitable for guiding the selection of patients for early treatment. Additionally, separate gene expression patterns were identified between acute MS relapse and remission, and treatment effects could also be identified. The methods described herein may also be used to offer superior insight into the biological mechanisms involved in the disease as well as improving functional gene characterization and transcription sites detection, important for identification of new targets for treatment and drug identification, such as T cell activation and expansion and anti-apoptotic genes like SLAM, PIP5K1-g and the NR4A1-3 steroid-thyroid receptors subfamily.  
     Example IV  
      Gene Expression Profiles of MOG-Reactive T-Cells from MS Patients  
      Although MS appears to be caused by autoimmune T cells activated against myelin self-antigens, myelin-reactive T-cells have been demonstrated in healthy subjects as well. Thus, distinction between disease-related and non-disease related T-cell myelin reactivity is of great clinical and investigational importance. In order to determine a profile of MS-related T-cell genes, gene expression in MOG-reactive T-cells from 4 MS patients having relapsing-remitting disease course, positive Poser criteria, and neurological disability, and 3 healthy age-matched controls was compared.  
      Using the microarray methods described herein, gene expression patterns obtained in MOG reactive T cell lines from MS patients detected 150 transcripts with TNoM=0, p=0.057 compared to healthy subjects ( FIG. 4 ). These high scoring gene transcripts were defined as significant MOG reactive MS-related genes. Hierarchical clustering of gene expression patterns from MS patients and healthy controls is presented in  FIG. 2 , panel A. From the 150 genes with absolutely different expression levels, 43 most informative genes were further identified and clustered. These include 18 up-regulated and 25 down-regulated genes ( FIG. 2 , panel B).  
      Investigation of the known biological function of these genes (Table V) shows a great diversity of activity (A Pie-chart diagram showing the functional groups of genes included in this evaluation is presented in  FIG. 3 ). Included are genes coding for proteins involved in the regulation and execution of apoptosis, growth factors, mediators of signal transduction pathways, molecules that participate in inflammation and also genes encoding heat shock proteins, transcription factors and components of different biochemical pathways.  
      Upregulated Genes in MS-Derived T-cells—Up-regulated in MS patient-derived T-cell lines are several anti-apoptotic genes such as BCL2, lifeguard, and the MAP-activated kinase MAP3K12. The BCL2 gene product is an important member of the anti-apoptotic proteins. Lifeguard (LFG), is a molecule that inhibits cell death mediated by the Fas (CD95) receptor through a unique mechanism that down regulates apoptotic signals from Fas and is associated with human autoimmune lymphoproliferative syndrome (ALPS) and in lymphoproliferative lupus-like syndrome in mice.  
      The MAP3K12 gene is associated with programmed cell death and encodes a polypeptide that catalyzes the phosphorylation of BAD, a member of the BCL2 anti-apoptosis protein family. Increased expression of IGFBP3 and VEGF was also demonstrated in MS-derived T cells. IGFBP-3 has been implicated in the expansion of disease related T-cell, associated with acute brain lesions of MS patients. Thus, in addition to increased survival potential, our findings suggest that autoreactive T cells in MS also have an expansion advantage compared with T cells from healthy individuals.  
      Furthermore, migration of autoimmune T cells into the brain would be expected to be assisted by over-expression of transcripts encoding for vascular endothelial growth factor (VEGF) in lines from MS patients. VEGF enhances vascular permeability and may facilitate migration of lymphocytes into the CNS and induction of inflammatory reactions in the brain.  
      Downregulated Genes in MS-Derived T-cells—The profile of gene expression in MS-derived T-cells ( FIG. 4 , and Table V) indicates a suppression of apoptosis-related functions in the diseased state. One aspect of failure to induce apoptosis in the MS-derived T cell lines is the significant down-regulation of the gene encoding for the pro-apoptotic molecule TNF. A reduction in TNF could also contribute to a reduction in the ratio of pro- and anti-apoptotic transcript expression in the anti-MOG T cell lines from MS patients compared to healthy controls. Indeed, inadequate apoptosis present in MS autoreactive T cell lines could lead to insufficient deletion of autoimmune activated T cell clones and increase susceptibility to autoimmunity.  
      In addition, effectors of MHC class I presentation were revealed to be down-regulated in MS patients&#39; cells. Such down-regulated expression includes the transcript for the proteasome PA28 complex, known to be a principal provider of MHC class I-presented peptides in antigen presenting cells, and HSP70 1A and 1B variants. TNF is also known to stimulate MHC class I presentation in addition to induction of apoptosis. The findings presented herein indicate that a weaker antigenic MHC class I presenting capability might distinguish MS-patient derived T cell lines from their healthy counterparts, and providing powerful diagnostic tools. It is conceivable that a lower expression of MHC class-I on CD4 autoimmune T cells might enable them to escape regulation by CD8 cells that recognize autoimmune idiotypes.  
      Taken together the combined effects of down-regulation of apoptosis associated genes, up regulation of anti-apoptotic genes, increased expansion capability by autoreactive T cells and enhanced ability to penetrate the CNS may lead to perpetuated pathologic cellular proliferation and tissue destruction within the CNS characteristic of MS, along with increased resistance to regulation. The specific gene expression profiles described herein can define some of the requirements for an individual to develop MS, and thus have important predictive value, especially in determining MS in the “probable” stage. It is noteworthy that despite activation in vitro with the same MOG epitope, anti-MOG T cells from healthy subjects did not attain the gene expression profile that characterized the MS patient-derived cells. The findings support the concept that not all autoimmune T cells are equal; autoimmune T cells from MS patients follow a unique pattern of T cell activation that appears to be more resilient to apoptosis and can support long term survival. Although T cell lines derived from MS patients and healthy donors responded to the same autoantigen, were both activated T cell populations that proliferated extensively in the presence of IL-2, the gene expression imprints that are unique to each group were preserved. These findings indicate the existence of different T-cell activation mechanisms. The nature of the stimuli that generate aberrant autoimmune T-cell gene expression has yet to be identified in order to determine whether their formation is merely the result of the chronic immune stimulation driven by other factors in MS, or whether such T cells function as primary drivers of the MS process. Characterization of such driver T cells, dictating the state of immunity/autoimmunity can also greatly contribute to understanding autoimmunity and possibly also for designing effective treatments for MS.  
               TABLE I                          Gene Expression Profile from PBMCs of MS vs. Healthy                                             Info   t-Test   Log Fold           Identifier   TNOM PValue   PValue   PValue   Change   Symbol                                             U78107   8.55E−11   1.94E−11   4.04E−12   −0.43769   NAPG       M15330   8.55E−11   8.55E−11   2.49E−12   −2.13825   IL1B       X15218   8.55E−11   8.55E−11    1.4E−10   −1.41501   SKI       AF024710   8.55E−11   8.55E−11   1.13E−12   −1.95537   VEGF       U09937   1.84E−09   4.16E−10   2.04E−09   −1.21578   HSUROKR7       AB018343   1.84E−09   4.16E−10   9.05E−12   0.383078   KIAA0800       X74039   1.84E−09   4.16E−10   1.51E−10   −0.67381   PLAUR       M64571   1.84E−09   1.84E−09   2.41E−11   0.416659   MAP4       U64197   1.84E−09   1.84E−09   2.95E−10   −0.62373   SCYA20       X68452   2.57E−08   2.93E−09   9.12E−11   −0.26618   CCND2       AB011161   2.57E−08   2.93E−09   9.64E−11   0.63432   PIP5K1C       L47738   2.57E−08   2.93E−09   7.54E−09   0.31646   PIR121       U78798   2.57E−08   2.93E−09   1.11E−06   −0.3172   TRAF6       M63904   2.57E−08   7.16E−09   5.38E−09   −0.59612   GNA15       U72066   2.57E−08   7.16E−09   4.33E−08   −0.34482   RBBP8       AI184802   2.64E−07   1.61E−08   2.67E−09   −0.21576   HPRP4P       AF077820   2.64E−07   1.61E−08   2.91E−08   0.656852   LRP5       L13740   2.64E−07   1.61E−08   5.83E−08   −1.45891   NR4A1       AL008583   2.64E−07   1.61E−08   1.12E−08   0.250082       Z24724   2.64E−07   1.61E−08   5.96E−09   −1.10426       D30783   2.57E−08   2.19E−08   8.95E−10   −1.65011   EREG       U47927   2.57E−08   2.19E−08   5.53E−09   0.545592   USP5       AI560890   2.57E−08   2.19E−08    1.8E−07   0.179028       Y00630   2.57E−08   3.69E−08   6.65E−09   −2.38485   SERPINB2       N90866   2.64E−07   8.23E−08   2.76E−08   0.304525   CDW52       AF022375   2.64E−07   8.23E−08   1.87E−11   −1.35847   VEGF       M24895   2.11E−06   1.08E−07   1.72E−08   0.476779   AMY2B       AF054176   2.11E−06   1.08E−07   6.47E−09   −0.58138   C1orf7       L20941   2.64E−07   1.08E−07   1.78E−06   −0.58618   FTH1       L05424   2.11E−06   1.08E−07   2.27E−09   −0.58081   HUMSCG19       AB002347   2.11E−06   1.08E−07   7.19E−10   0.371731   KIAA0349       AB023153   2.11E−06   1.08E−07   1.82E−08   0.895842   KIAA0936       AF069517   2.11E−06   1.08E−07   4.91E−07   0.399638   RBM6       X69392   2.64E−07   1.08E−07    1.1E−08   0.297444   RPL26       U51920   2.11E−06   1.08E−07   7.01E−08   −0.28142   SRP54       L22075   2.64E−07   1.71E−07    1.1E−08   −0.55736   GNA13       X04500   2.64E−07   1.71E−07   3.43E−10   −2.12121   IL1B       AB028951   2.64E−07   1.71E−07   8.78E−09   0.543028   KIAA1028       AF004230   2.64E−07   1.71E−07   3.06E−07   0.349166   LILRB1       AF070582   2.64E−07   1.71E−07   3.23E−08   −0.19773   MGC13033       X66363   2.64E−07   1.71E−07   6.53E−07   −0.24505   PCTK1       L33881   2.64E−07   1.71E−07   5.06E−08   −0.59585   PRKCI       U33017   2.64E−07   1.71E−07    5.2E−07   0.373581   SLAM       AJ007042   2.64E−07   1.71E−07    2.1E−07   0.170935   WHSC1       Z93930   2.64E−07   1.71E−07   2.42E−05   −0.39839   XBP1       AF079167   2.64E−07   1.71E−07   7.37E−10   −1.93249       AF098641   2.64E−07   1.71E−07   1.56E−07   −0.41172       HG3227-HT3404   2.64E−07   1.71E−07   1.68E−08   −0.25361       U78302   2.64E−07   1.71E−07   2.41E−08   0.329878       U91543   2.64E−07   2.49E−07   2.01E−07   0.478678   CHD3       M22919   2.64E−07   2.49E−07   9.52E−08   −0.81053   MYL6       AB029015   2.64E−07   2.49E−07   5.37E−09   0.695063   PLCE2       Z11697   1.37E−05   4.08E−07   3.55E−06   −1.21033   CD83       AL096780   1.37E−05   4.08E−07   2.13E−06   0.34487   CHKL       U51205   1.37E−05   4.08E−07   2.65E−07   −0.76279   COP9       Y08683   1.37E−05   4.08E−07   4.71E−06   0.492738   CPT1B       S52028   2.11E−06   4.08E−07   9.62E−08   −0.81662   CTH       X63368   2.11E−06   4.08E−07    2.3E−08   −0.55432   DNAJB2       M84443   1.37E−05   4.08E−07   4.08E−07   0.303567   GALK2       U32324   1.37E−05   4.08E−07   3.21E−08   0.334966   IL11RA       AB011115   1.37E−05   4.08E−07   3.39E−07   0.382809   KIAA0543       AB014535   1.37E−05   4.08E−07   1.04E−06   0.285282   KIAA0635       X02152   1.37E−05   4.08E−07   4.63E−08   −0.75601   LDHA       AF007130   2.11E−06   4.08E−07   2.51E−06   0.391811   LOC54104       AF007151   1.37E−05   4.08E−07   3.25E−06   0.468343   MMS19L       X82209   2.11E−06   4.08E−07   1.37E−09   −0.45281   MN1       X79882   1.37E−05   4.08E−07   1.78E−07   0.520965   MVP       U91616   1.37E−05   4.08E−07   1.27E−07   −0.80419   NFKBIE       U41815   1.37E−05   4.08E−07   2.16E−07   −0.96931   NUP98       AB011108   1.37E−05   4.08E−07   4.39E−07   0.453498   PRP4       L40377   1.37E−05   4.08E−07   3.49E−07   −0.79409   SERPINB8       X99656   1.37E−05   4.08E−07   1.68E−06   −0.23553   SH3GL1       AJ010059   2.11E−06   4.08E−07   2.95E−06   0.2235   SIT       J02973   1.37E−05   4.08E−07   2.93E−07   −1.30804   THBD       N90862   1.37E−05   4.08E−07   3.28E−08   0.43576   VAMP8       Y14768   1.37E−05   4.08E−07   7.26E−08   0.248383       U47414   2.11E−06   7.73E−07   2.31E−06   0.370736   CCNG2       AB002386   2.11E−06   7.73E−07   5.34E−09   0.586117   EZH1       U29344   2.11E−06   7.73E−07   2.35E−07   −0.43842   FASN       AF015553   2.11E−06   7.73E−07   2.61E−07   0.61214   GTF2I       AB028981   2.11E−06   7.73E−07   5.34E−07   0.282288   KIAA1058       U29656   2.11E−06   7.73E−07   7.52E−08   0.353186   NME3       X00737   2.11E−06   7.73E−07   5.21E−08   −0.67074   NP       U29185   2.11E−06   7.73E−07   1.56E−07   −1.08006   PRNP       AB007960   2.11E−06   7.73E−07   7.96E−06   0.447772   SH3GLB1       U44839   2.11E−06   7.73E−07   2.54E−07   −0.97008   USP11       U84007   7.44E−05   1.28E−06   0.000235   0.236422   AGL       S78187   7.44E−05   1.28E−06   1.95E−05   0.203265   CDC25B       X82153   7.44E−05   1.28E−06   2.27E−06   0.47844   CTSK       AL050084   7.44E−05   1.28E−06   5.26E−05   0.509331   DC8       X62535   1.37E−05   1.28E−06   5.68E−07   0.243937   DGKA       AB026436   7.44E−05   1.28E−06   0.000219   −0.7589   DUSP10       M98833   7.44E−05   1.28E−06   1.52E−06   0.434288   FL11       AW051579   1.37E−05   1.28E−06   7.58E−07   0.593476   FLJ10512       X16706   7.44E−05   1.28E−06   1.23E−06   −1.09747   FOSL2       U90917   1.37E−05   1.28E−06   3.89E−07   0.433406   FOXM1       M24194   7.44E−05   1.28E−06   4.38E−06   0.560895   GNB2L1       AJ002190   7.44E−05   1.28E−06   2.17E−08   0.33775   GNPAT       X87949   7.44E−05   1.28E−06   4.05E−07   −0.54468   HSPA5       U96876   7.44E−05   1.28E−06   3.54E−06   −0.45317   INSIG1       AF038564   1.37E−05   1.28E−06   2.05E−07   −0.40446   ITCH       D80011   7.44E−05   1.28E−06    4.2E−07   −0.35073   KIAA0189       AI950382   1.37E−05   1.28E−06   1.63E−07   −0.74128   KIAA0585       AB023235   7.44E−05   1.28E−06   1.43E−05   0.311216   KIAA1018       AB029038   7.44E−05   1.28E−06   7.62E−05   0.364386   KIAA1115       U24166   7.44E−05   1.28E−06   7.52E−06   −0.45293   MAPRE1       X61498   7.44E−05   1.28E−06    8.8E−07   −0.49884   NFKB2       U12767   7.44E−05   1.28E−06   2.84E−07   −1.23483   NR4A3       U85245   7.44E−05   1.28E−06   4.57E−07   0.365266   PIP5K2B       U50928   7.44E−05   1.28E−06   4.72E−06   0.302213   PKD2       U13695   7.44E−05   1.28E−06   1.11E−05   0.805607   PMS1       AA203527   1.37E−05   1.28E−06   1.18E−07   0.281992   RPP20       J02939   7.44E−05   1.28E−06   2.16E−07   −0.87844   SLC3A2       N30151   7.44E−05   1.28E−06   5.05E−05   0.393521   STX16       U52960   2.11E−06   1.28E−06   1.51E−07   −0.84863   SURB7       AF030249   1.37E−05   1.28E−06   1.98E−07   0.534547       AL022398   7.44E−05   1.28E−06   8.09E−08   0.919627       HG1103-HT1103   1.37E−05   1.28E−06   1.16E−07   −0.39165       D30758   2.11E−06    1.8E−06   1.58E−05   0.27738   CENTB1       U75968   2.11E−06    1.8E−06   4.36E−06   0.139542   DDX11       M69199   2.11E−06    1.8E−06   1.45E−07   −1.9021   G0S2       U20982   2.11E−06    1.8E−06    1.2E−08   −0.67125   IGFBP4       AF040707   2.11E−06    1.8E−06   3.57E−07   0.289845   NPR2L       AB007927   2.11E−06    1.8E−06   2.12E−07   0.323787   RERE       AA902713   2.11E−06    1.8E−06   1.44E−06   0.474378       U66063   2.11E−06   2.24E−06    4.7E−07   0.277185   CAMK2G       D13891   2.11E−06   2.24E−06   4.57E−05   −0.20577   ID2       AL050087   2.11E−06   2.24E−06   1.27E−07   −0.31279   KIAA1785       N23137   2.11E−06   2.24E−06   2.06E−07   0.247311   MPHOSPH9       N42007   2.11E−06   2.24E−06   9.19E−05   0.167986   NUP50       M74525   2.11E−06   2.24E−06    3.5E−07   −0.61792   UBE2B       AF035281   2.11E−06   2.24E−06   4.87E−07   0.472445       U11732   1.37E−05   3.17E−06   3.04E−07   −0.22574   ETV6       AB002348   1.37E−05   3.17E−06   2.49E−07   0.576346   KIAA0350       AB007891   1.37E−05   3.17E−06   3.99E−05   0.196376   KIAA0431       AI754391   1.37E−05   3.17E−06   1.72E−06   −0.27657   KLF12       D50406   1.37E−05   3.17E−06   2.65E−05   0.461907   RECK       AF070617   1.37E−05   3.17E−06   3.23E−07   0.323494       M23114   2.11E−06   4.08E−06   1.59E−07   −0.96141   ATP2A2       AF014958   2.11E−06   4.08E−06   1.05E−07   −0.42152   CCRL2       AF067853   1.37E−05   4.31E−06   5.02E−06   0.361707   ADSL       M73547   1.37E−05   4.31E−06    9.2E−08   0.438897   D5S346       W28319   1.37E−05   4.31E−06    1.5E−05   0.294631   FBLN1       AB007895   1.37E−05   4.31E−06   9.61E−07   0.186643   KIAA0435       AB014579   1.37E−05   4.31E−06   6.08E−08   0.367966   MGEA5       AF019083   1.37E−05   4.31E−06   8.34E−07   0.17011   PTENP1       AL080141   1.37E−05   4.31E−06   2.42E−07   0.330868   SEC31B-1       AF110377   1.37E−05   4.31E−06   3.05E−05   0.361232   TRRAP       AB002448   1.37E−05   4.31E−06   2.45E−07   0.468926       AL049787   1.37E−05   4.31E−06   7.11E−06   0.311278       U50527   1.37E−05   4.31E−06   5.11E−06   0.416543       Z32860   1.37E−05   4.31E−06   7.81E−06   0.133192       AF094481   1.37E−05   5.01E−06   2.74E−07   −0.29045   CGGBP1       U29171   1.37E−05   5.01E−06    1.1E−06   −0.6032   CSNK1D       AL050196   1.37E−05   5.01E−06     2E−05   −0.24688   DKFZP586D2223       U48807   1.37E−05   5.01E−06   4.97E−08   −0.93178   DUSP4       U15552   1.37E−05   5.01E−06   1.67E−05   −0.68094   HSU15552       L13740   1.37E−05   5.01E−06    9.1E−08   −0.61928   NR4A1       AF010309   1.37E−05   5.01E−06   7.36E−07   −0.28533   PIG3       Y18004   1.37E−05   5.01E−06   4.19E−07   −0.9465   SCML2       R90942   1.37E−05   5.01E−06   1.05E−05   −0.17696   ST6GALNACIV       W28612   1.37E−05   5.01E−06    1.7E−06   −0.25519       X64330   7.44E−05   6.03E−06   2.27E−06   0.297851   ACLY       U49844   7.44E−05   6.03E−06   3.67E−07   0.47168   ATR       AB015019   7.44E−05   6.03E−06   2.75E−07   −0.24515   BAIAP2       AF006513   0.000344   6.03E−06   4.48E−05   −1.45973   CHD1       U56998   0.000344   6.03E−06    3.7E−06   −0.74294   CNK       S68134   0.000344   6.03E−06   8.37E−07   −1.64652   CREM       S68134   0.000344   6.03E−06   4.35E−06   −2.47105   CREM       S68271   0.000344   6.03E−06   3.03E−06   −2.07185   CREM       AF021819   0.000344   6.03E−06   4.41E−05   0.298771   DJ-1       AF029777   1.37E−05   6.03E−06   8.27E−07   0.290159   GCN5L2       U28811   0.000344   6.03E−06   1.33E−06   0.32855   GLG1       S81914   0.000344   6.03E−06   4.18E−07   −1.59146   IER3       X80821   0.000344   6.03E−06   8.51E−05   −0.5606   KIAA0874       L06895   7.44E−05   6.03E−06   1.12E−05   −0.1928   MAD       D78579   1.37E−05   6.03E−06   4.25E−07   −1.65638   NR4A3       D78579   7.44E−05   6.03E−06   9.62E−07   −1.61438   NR4A3       U12767   0.000344   6.03E−06   2.55E−07   −2.13744   NR4A3       M95678   0.000344   6.03E−06     2E−06   0.432923   PLCB2       X51804   0.000344   6.03E−06   7.23E−05   −0.19283   PMI       W28743   0.000344   6.03E−06   2.78E−06   −0.28926   PP1628       X17042   7.44E−05   6.03E−06   6.64E−06   −0.36481   PRG1       M80244   0.000344   6.03E−06   2.72E−06   −0.8522   SLC7A5       AF001294   1.37E−05   6.03E−06   1.23E−06   −0.76359   TSSC3       D49677   7.44E−05   6.03E−06   4.18E−06   0.198707   U2AF1RS2       AB011004   0.000344   6.03E−06   1.41E−06   −1.34073   UAP1       AB011113   1.37E−05   6.03E−06   3.74E−07   0.444795   WDR7       AC002394   0.000344   6.03E−06   0.001473   0.17105       AL021707   0.000344   6.03E−06   4.95E−06   −2.21462       AL022398   7.44E−05   6.03E−06    1.1E−07   0.79713       AL049442   0.000344   6.03E−06   8.09E−06   0.621935       U17760   0.000344   6.03E−06   4.25E−06   −0.84472       L22569   1.37E−05   8.66E−06   1.52E−06   0.318129   CTSB       AL031058   1.37E−05   8.66E−06   0.000375   0.149046   DSP       AL080172   1.37E−05   8.66E−06   1.89E−05   0.098968   FLJ21919       M36821   1.37E−05   8.66E−06   2.21E−07   −0.36334   GRO3       U06631   1.37E−05   8.66E−06   1.31E−05   0.486332   H326       L16499   1.37E−05   8.66E−06   5.12E−06   0.374296   HHEX       X53586   1.37E−05   8.66E−06    3.4E−07   0.51291   ITGA6       D87466   1.37E−05   8.66E−06   1.49E−07   0.466046   KIAA0276       N98667   1.37E−05   8.66E−06   3.38E−07   0.367127   KIAA1696       X99142   1.37E−05   8.66E−06   1.24E−06   −0.29773   KRTHB6       AF011333   1.37E−05   8.66E−06   1.55E−05   0.342503   LY75       U70735   1.37E−05   8.66E−06   1.82E−06   0.249185   MOV34-34KD       U02020   1.37E−05   8.66E−06   1.37E−06   −1.13863   PBEF       M31724   1.37E−05   8.66E−06   0.000172   −0.2601   PTPN1       U29175   1.37E−05   8.66E−06    1.9E−06   0.266342   SMARCA4       AL031846   1.37E−05   8.66E−06   0.000418   0.38404       Y12059   7.44E−05   1.51E−05   5.64E−06   −0.46008   BRD4       U49187   7.44E−05   1.51E−05   1.48E−06   0.671467   C6orf32       X66945   7.44E−05   1.51E−05   1.91E−07   −0.35494   FGFR1       M60922   7.44E−05   1.51E−05   4.47E−08   0.39657   FLOT2       AL049409   7.44E−05   1.51E−05    1.1E−06   0.714173   LEF1       L16794   7.44E−05   1.51E−05   2.23E−05   −0.27553   MEF2D       U77735   7.44E−05   1.51E−05   5.66E−06   0.574142   PIM2       U10117   7.44E−05   1.51E−05   4.07E−06   0.563673   SCYE1       AF023614   1.37E−05   1.51E−05   4.79E−07   −0.20744   TACI       S73591   1.37E−05   1.51E−05   4.68E−06   0.414777   VDUP1       AF052160   7.44E−05   1.51E−05   1.67E−06   0.623021       L76528   7.44E−05   1.51E−05   6.14E−06   −0.39652       U51007   7.44E−05   1.51E−05   1.49E−06   0.309996       D10704   1.37E−05   1.75E−05   4.69E−07   −0.36791   CHK       U97105   1.37E−05   1.75E−05   6.56E−07   1.00615   DPYSL2       U03634   1.37E−05   1.75E−05     1E−06   −0.21467   LBC       L13773   1.37E−05   1.75E−05   6.44E−07   0.247919   MLLT2       M31523   1.37E−05   1.75E−05   2.09E−06   0.36898   TCF3       AL023553   1.37E−05   1.75E−05   2.51E−06   0.226635       W25984   7.44E−05   2.35E−05   1.42E−05   0.482493   ACTA1       U78521   0.000344   2.35E−05   2.53E−05   0.320909   AIP       M30704   0.000344   2.35E−05   1.65E−05   −0.37795   AREG       X91504   0.001377   2.35E−05   0.00016   0.233217   ARFRP1       U51478   7.44E−05   2.35E−05    6.1E−07   −0.58   ATP1B3       U21551   0.001377   2.35E−05   7.6E−05   −0.3088   BCAT1       AB004066   0.000344   2.35E−05   6.57E−05   −0.60905   BHLHB2       M59040   0.001377   2.35E−05   2.82E−06   −0.46271   CD44       M91670   0.001377   2.35E−05   0.001649   −0.47538   E2-EPF       U43774   0.000344   2.35E−05    8.8E−07   −0.39938   FCAR       AW024285   0.000344   2.35E−05   6.99E−06   −0.42098   FLJ12443       AA780049   7.44E−05   2.35E−05   7.39E−07   0.54912   FLJ21439       AI935146   0.000344   2.35E−05   2.05E−06   −0.46726   GALNT3       AJ011679   0.001377   2.35E−05   4.67E−05   0.243248   GAPCENA       AI670100   7.44E−05   2.35E−05    7.7E−07   0.22677   GRLF1       D87119   7.44E−05   2.35E−05    1.8E−06   0.425625   GS3955       M92432   0.000344   2.35E−05   4.31E−05   0.363033   GUCY2D       D50405   0.001377   2.35E−05   0.000688   0.387926   HDAC1       U07563   7.44E−05   2.35E−05   4.91E−07   −0.25016   HSABLGR3       Y10313   0.001377   2.35E−05   0.003201   −0.35345   IFRD1       D63485   0.000344   2.35E−05   9.04E−05   0.31177   IKKE       L08488   0.000344   2.35E−05   7.54E−06   −0.37883   INPP1       X06256   1.37E−05   2.35E−05   4.89E−07   −0.7357   ITGA5       D42084   0.001377   2.35E−05   7.39E−06   0.222195   KIAA0094       D43947   7.44E−05   2.35E−05   0.000104   0.269941   KIAA0100       AB007870   0.000344   2.35E−05   0.000108   −0.64362   KIAA0410       AI950382   0.000344   2.35E−05   0.000122   −0.65985   KIAA0585       AB014548   7.44E−05   2.35E−05   2.77E−05   0.431229   KIAA0648       AB018297   0.001377   2.35E−05   0.000836   0.195704   KIAA0754       AI970189   0.000344   2.35E−05   6.16E−07   −0.75934   KIAA0997       L04733   0.001377   2.35E−05   8.84E−07   0.306455   KNS2       AF010193   7.44E−05   2.35E−05   1.26E−07   −1.4705   MADH7       U18919   7.44E−05   2.35E−05   1.05E−05   0.271231   NBP       U85430   0.001377   2.35E−05   0.000315   0.317554   NFATC3       S76638   7.44E−05   2.35E−05   7.47E−07   −0.35416   NFKB2       AL050353   0.000344   2.35E−05   4.42E−06   0.179352   OIP2       L20971   0.001377   2.35E−05   0.00089   −0.49725   PDE4B       AF060502   7.44E−05   2.35E−05   0.000114   −0.18239   PEX10       X80497   0.001377   2.35E−05   0.000245   0.313262   PHKA2       AL050371   0.000344   2.35E−05    3.7E−06   0.493288   PISD       U77718   7.44E−05   2.35E−05    6.6E−06   0.352996   PNN       U52427   0.001377   2.35E−05   0.000282   0.329478   POLR2G       U94778   0.000344   2.35E−05   1.18E−05   0.282929   PSTPIP1       U48296   0.001377   2.35E−05   0.00011   −0.89871   PTP4A1       M31166   0.001377   2.35E−05   0.000256   −0.38484   PTX3       AJ001016   7.44E−05   2.35E−05   1.08E−05   −0.28245   RAMP3       AF040965   0.001377   2.35E−05   0.001101   −0.38591   RES4-25       J04130   0.000344   2.35E−05   3.02E−06   −0.62071   SCYA4       U81800   0.000344   2.35E−05   4.28E−05   −0.49523   SLC16A3       AB000734   0.001377   2.35E−05   0.000883   −0.58764   SSI-1       U38847   7.44E−05   2.35E−05   9.91E−07   0.222946   TARBP1       M63180   0.001377   2.35E−05   1.03E−05   −0.33301   TARS       D15050   0.001377   2.35E−05   0.000192   −1.12874   TCF8       M12959   7.44E−05   2.35E−05   1.61E−06   0.128482   TRA@       X00734   0.001377   2.35E−05   0.000384   −0.34516   TUBB5       AJ001340   0.001377   2.35E−05   4.21E−05   0.181208   U3-55K       Y08614   0.001377   2.35E−05   6.92E−05   0.305659   XPO1       AF054589   0.000344   2.35E−05   1.98E−06   0.945394       AL022398   7.44E−05   2.35E−05    2.4E−06   0.493166       AL031178   7.44E−05   2.35E−05   3.18E−05   0.410068       AL049782   7.44E−05   2.35E−05   7.66E−07   0.237794       HG1471-HT3923   0.001377   2.35E−05   0.000519   0.203133       HG4582-HT4987   7.44E−05   2.35E−05   4.63E−07   −0.39588       U96629   0.001377   2.35E−05     1E−04   0.277256       D64110   7.44E−05   2.58E−05   7.49E−05   −0.51036   BTG3       J04111   7.44E−05   2.58E−05   0.000108   −1.60276   JUN       J04111   7.44E−05   2.58E−05   4.68E−05   −1.14014   JUN       X56681   7.44E−05   2.58E−05   0.000112   −0.48711   JUND       D21853   7.44E−05   2.58E−05   0.000403   −0.25594   KIAA0111       X80692   7.44E−05   2.58E−05   3.44E−05   −1.1939   MAPK6       S76638   7.44E−05   2.58E−05   5.23E−05   −0.46026   NFKB2       U65785   7.44E−05   2.58E−05   9.67E−06   −0.2389   ORP150       AB016247   7.44E−05   2.58E−05   3.13E−05   −0.57287   SC5DL       M55153   7.44E−05   2.58E−05   4.77E−06   −0.27465   TGM2       U02570   1.37E−05   2.81E−05   1.26E−06   0.432431   ARHGAP1       X04366   1.37E−05   2.81E−05   5.11E−06   0.346076   CAPN1       L10413   1.37E−05   2.81E−05   6.46E−06   0.207231   FNTA       AF055001   1.37E−05   2.81E−05   9.78E−06   −0.9457   HERPUD1       AI523538   1.37E−05   2.81E−05   0.004471   −0.1584   HIPK3       X59373   1.37E−05   2.81E−05   1.31E−05   −0.22992   HOXD10       X99209   1.37E−05   2.81E−05   2.65E−05   0.239777   HRMT1L1       M65217   1.37E−05   2.81E−05   1.02E−05   0.33377   HSF2       X17025   1.37E−05   2.81E−05   1.45E−05   −0.44351   IDI1       M35878   1.37E−05   2.81E−05   4.29E−05   −0.25267   IGFBP3       D63486   1.37E−05   2.81E−05   9.69E−06   0.235319   KIAA0152       AB002303   1.37E−05   2.81E−05   1.86E−05   −0.39642   KIAA0305       U20816   1.37E−05   2.81E−05   4.92E−05   −0.20145   NFKB2       M61906   1.37E−05   2.81E−05   5.93E−06   −0.39875   PIK3R1       U13695   1.37E−05   2.81E−05   1.31E−05   0.362255   PMS1       U38979   1.37E−05   2.81E−05   3.95E−05   0.158105   PMS2L9       X70218   1.37E−05   2.81E−05   2.44E−06   −0.74691   PPP4C       AC002400   1.37E−05   2.81E−05   2.28E−06   −0.25834       AC005390   1.37E−05   2.81E−05   2.99E−05   −0.24231       AF070606   1.37E−05   2.81E−05   1.48E−06   0.89337       HG2724-HT2820   1.37E−05   2.81E−05   5.17E−06   −1.33814       X84194   7.44E−05   4.67E−05   6.38E−05   0.23578   ACYP1       AF039656   0.00482   4.67E−05   0.000251   −0.73273   BASP1       AB002384   0.00482   4.67E−05   4.22E−05   0.548091   C6orf32       X98172   7.44E−05   4.67E−05   5.29E−07   0.507556   CASP8       U60521   7.44E−05   4.67E−05   8.13E−06   −0.36762   CASP9       U11791   0.00482   4.67E−05   0.000363   −1.0232   CCNH       U67615   0.00482   4.67E−05   0.000948   1.23433   CHS1       AF037339   0.000344   4.67E−05   1.59E−05   −0.33549   CLPTM1       U65928   7.44E−05   4.67E−05   2.85E−07   0.408918   COPS5       U37408   7.44E−05   4.67E−05   3.06E−05   0.157458   CTBP1       AB023143   0.00482   4.67E−05   0.001982   0.215415   DEFCAP       AB014888   0.001377   4.67E−05   0.000204   −0.34841   DNAJB6       M60278   0.00482   4.67E−05   3.33E−05   −0.9007   DTR       U88629   0.000344   4.67E−05   9.58E−07   −0.32607   ELL2       M31899   0.000344   4.67E−05   0.000339   0.274507   ERCC3       M94856   7.44E−05   4.67E−05   4.99E−06   −0.23847   FABP5       X86779   0.001377   4.67E−05   1.08E−05   0.140032   FASTK       L00634   0.00482   4.67E−05   0.00019   0.205256   FNTA       AF078077   0.000344   4.67E−05   1.44E−05   −1.47649   GADD45B       D87119   7.44E−05   4.67E−05   4.62E−06   0.557116   GS3955       X17644   7.44E−05   4.67E−05   6.72E−06   −0.71963   GSPT1       L19314   0.00482   4.67E−05   0.000922   −0.35113   HRY       U05681   7.44E−05   4.67E−05   3.37E−06   −0.35383   HSBCL3S2       J00139   0.00482   4.67E−05   0.000196   −0.12797   HUMFOL5       M24283   0.000344   4.67E−05   3.71E−06   −1.32611   ICAM1       M62403   7.44E−05   4.67E−05   5.57E−07   −0.53749   IGFBP4       M28130   7.44E−05   4.67E−05   8.02E−07   −2.27292   IL8       Z56281   0.001377   4.67E−05   0.000243   0.309173   IRF3       L12002   7.44E−05   4.67E−05   1.23E−06   0.286717   ITGA4       K00558   0.001377   4.67E−05   0.002498   0.12909   K-ALPHA-1       AL044599   0.001377   4.67E−05   8.81E−05   0.321294   KIAA0222       AB002344   0.000344   4.67E−05   1.04E−05   −0.39307   KIAA0346       AB007889   7.44E−05   4.67E−05   2.33E−05   0.255643   KIAA0429       AB007916   0.00482   4.67E−05   0.000147   0.493018   KIAA0447       AB014538   0.000344   4.67E−05   1.98E−06   −0.63923   KIAA0638       AF055004   7.44E−05   4.67E−05   9.29E−05   0.200537   KIAA0763       AI148772   0.000344   4.67E−05   4.18E−06   −1.02619   KYNU       AF064491   0.00482   4.67E−05   0.000148   −0.54215   LDB1       L78132   7.44E−05   4.67E−05   5.15E−07   0.358576   LGALS8       X83441   7.44E−05   4.67E−05   6.75E−06   −0.17796   LIG4       AF055581   7.44E−05   4.67E−05   5.69E−06   −1.05728   LNK       AL049963   0.000344   4.67E−05   8.36E−07   −0.74421   LOC64116       AF014837   0.00482   4.67E−05   0.000636   0.325349   M6A       D14497   0.001377   4.67E−05   3.68E−05   −0.58619   MAP3K8       X75346   7.44E−05   4.67E−05   1.99E−05   −0.37877   MAPKAPK2       M62324   0.001377   4.67E−05   5.46E−05   −0.44552   MRF-1       AB023208   0.000344   4.67E−05   1.37E−05   0.293901   MSF       AF072928   0.001377   4.67E−05   1.13E−05   −0.3089   MTMR6       AF045451   0.000344   4.67E−05   6.34E−06   −0.40149   NAB1       M58603   7.44E−05   4.67E−05   1.28E−06   −0.73537   NFKB1       U07132   0.00482   4.67E−05   0.001821   −0.14679   NR1H2       X75918   7.44E−05   4.67E−05    3.5E−05   −1.61126   NR4A2       S77154   0.00482   4.67E−05   0.000304   −1.33785   NR4A2       AB020657   0.00482   4.67E−05   2.75E−05   −0.50544   NS1-BP       D88674   7.44E−05   4.67E−05   6.26E−06   −0.99818   OAZIN       U27459   0.00482   4.67E−05   3.39E−05   0.430016   ORC2L       AF000545   7.44E−05   4.67E−05   3.48E−06   −0.85393   P2Y10       AF005043   7.44E−05   4.67E−05    2.7E−06   0.408592   PARG       AF026086   0.000344   4.67E−05   2.66E−06   0.297942   PEX1       AJ001625   7.44E−05   4.67E−05   9.91E−05   0.36837   PEX3       U30255   0.001377   4.67E−05   0.000826   0.325906   PGD       M61906   0.000344   4.67E−05   0.000611   −0.2492   PIK3R1       M60483   0.000344   4.67E−05   3.17E−05   −0.32565   PPP2CA       U14603   7.44E−05   4.67E−05   4.46E−05   0.427268   PTP4A2       AF069517   0.001377   4.67E−05   0.000441   0.330897   RBM6       M83221   0.000344   4.67E−05   1.58E−05   −0.26782   RELB       AF037195   0.00482   4.67E−05   8.27E−05   0.959619   RGS14       L07597   0.00482   4.67E−05   0.000169   0.277243   RPS6KA1       X15217   7.44E−05   4.67E−05   3.77E−07   −0.2371   SKIL       M20681   0.001377   4.67E−05   1.92E−05   −0.99917   SLC2A3       AF030409   7.44E−05   4.67E−05   7.66E−06   0.412043   SLC9A6       AJ224358   0.00482   4.67E−05   0.009613   0.14432   SURF5       U49928   0.000344   4.67E−05   6.31E−06   0.352648   TAB1       X89750   7.44E−05   4.67E−05   7.38E−06   −1.51687   TGIF       AA453183   0.001377   4.67E−05   4.48E−05   −0.61646   TIM17       M31165   7.44E−05   4.67E−05   1.38E−06   −0.34617   TNFAIP6       AF064090   0.001377   4.67E−05   4.05E−05   −0.38921   TNFSF14       AF082557   0.001377   4.67E−05   2.23E−06   0.226994   TNKS       D87448   0.00482   4.67E−05   0.000735   0.468196   TOPBP1       X05276   0.00482   4.67E−05   8.97E−05   −0.50457   TPM4       D50919   0.00482   4.67E−05   4.02E−05   0.332326   TRIM14       J03258   0.00482   4.67E−05   8.78E−05   −0.33021   VDR       AB007973   0.00482   4.67E−05   0.000146   0.271053       AF041081   0.00482   4.67E−05   5.92E−05   0.26539       AI889718   7.44E−05   4.67E−05   0.000143   −0.15002       AL021154   0.000344   4.67E−05   2.19E−06   −0.82935       AL049340   0.000344   4.67E−05   4.87E−05   −0.91769       AL050078   0.000344   4.67E−05   1.63E−05   −0.2875       AL050378   0.000344   4.67E−05   5.72E−06   0.360577       D50525   0.000344   4.67E−05   3.02E−06   0.486698       J04755   7.44E−05   4.67E−05   6.75E−05   −0.37296       M60784   7.44E−05   4.67E−05   1.24E−06   0.559903       M63978   0.000344   4.67E−05   1.77E−06   −0.44762       U90909   0.00482   4.67E−05   3.74E−05   −0.64272       X63547   0.001377   4.67E−05   0.000303   0.505712       AA135683   0.000344   5.23E−05   0.000289   −0.69258   BASP1       S78771   0.000344   5.23E−05   2.55E−06   −0.31389   BRD2       AL080156   0.000344   5.23E−05   3.52E−05   −0.94419   DKFZP434J214       D14838   0.000344   5.23E−05   7.34E−06   −0.50648   FGF9       W28281   0.000344   5.23E−05   8.96E−06   −1.09149   GABARAIPL1       AB002344   7.44E−05   5.23E−05   8.48E−07   −1.00068   KIAA0346       U23070   0.000344   5.23E−05   3.62E−05   −0.12321   NMA       U04636   0.000344   5.23E−05   2.81E−06   −1.85123   PTGS2       U47634   0.000344   5.23E−05   0.002405   −0.21686   TUBB4       S73149   0.000344   5.23E−05   0.003714   −0.15741       M63256   0.000344   5.92E−05   6.54E−07   0.454561   CDR2       U94905   0.000344   5.92E−05   2.08E−05   0.388608   DGKZ       AF012023   7.44E−05   5.92E−05   1.02E−06   0.50623   ICAP-1A       L10717   0.000344   5.92E−05   0.000158   0.345558   ITK       D29642   0.000344   5.92E−05    8.3E−06   0.327019   KIAA0053       AB011128   0.000344   5.92E−05   0.000584   0.151161   KIAA0556       AF075587   0.000344   5.92E−05   7.55E−06   0.4405   KIAA0916       U66464   0.000344   5.92E−05   2.93E−05   0.255675   MAP4K1       U18919   0.000344   5.92E−05   0.000573   0.277847   NBP       X58965   0.000344   5.92E−05   7.34E−05   0.231912   NME2       X13403   7.44E−05   5.92E−05   4.21E−07   0.146032   POU2F1       D89859   0.000344   5.92E−05   1.56E−05   0.375402   ZFP161       AF052100   0.000344   5.92E−05   1.37E−05   0.290021       N53547   7.44E−05   7.24E−05    1.8E−07   0.296678   MGC5508       L35013   0.000344   7.24E−05   0.000112   −0.17331   SF3B4       Y17829   7.44E−05   7.24E−05   5.49E−06   −0.6508   SYN47       AL049987   7.44E−05   7.24E−05   2.39E−05   0.193082       X66436   0.000344   7.24E−05   1.88E−06   −0.26662       Z80345   7.44E−05   9.64E−05   7.31E−06   0.412137   ACADS       U27467   7.44E−05   9.64E−05   5.65E−06   −0.56637   BCL2A1       AI961669   7.44E−05   9.64E−05   0.000107   −0.1656   BIG2       X61123   7.44E−05   9.64E−05   4.17E−07   −1.15256   BTG1       U49187   7.44E−05   9.64E−05   3.53E−06   0.511392   C6orf32       D13639   7.44E−05   9.64E−05   8.56E−06   −0.64255   CCND2       AL035398   7.44E−05   9.64E−05   0.000153   0.353395   CGI-51       U15932   7.44E−05   9.64E−05   0.00031   −1.26603   DUSP5       AD001530   7.44E−05   9.64E−05   3.06E−05   −0.37019   DXS9928E       Y07909   7.44E−05   9.64E−05   0.000161   −0.23489   EMP1       W27152   7.44E−05   9.64E−05   0.000502   0.186359   FLJ10569       L17131   7.44E−05   9.64E−05   1.48E−05   −0.24039   HMGIY       X04430   7.44E−05   9.64E−05   4.15E−05   −0.21816   IL6       AB014608   7.44E−05   9.64E−05   4.59E−06   0.41494   KIAA0708       AF061258   7.44E−05   9.64E−05   1.58E−06   0.622201   LIM       U90919   7.44E−05   9.64E−05   7.23E−06   −0.50014   LOC57862       J05037   7.44E−05   9.64E−05   0.000185   −0.19243   SDS       X70944   7.44E−05   9.64E−05   2.08E−05   −0.72892   SFPQ       L41887   7.44E−05   9.64E−05   6.74E−06   −0.52203   SFRS7       X59871   7.44E−05   9.64E−05   1.91E−05   0.376648   TCF7       AI742846   7.44E−05   9.64E−05   0.000374   −0.48069   VAPA       HG2007-HT2056   7.44E−05   9.64E−05   4.01E−06   −0.41408       X58141   7.44E−05   9.64E−05   1.75E−06   0.384254       AB018323   7.44E−05   0.000106   2.41E−05   0.432301   GASC1       AB023192   7.44E−05   0.000106   0.000138   0.196185   I-1       AB020638   7.44E−05   0.000106   5.26E−05   0.233629   KIAA0831       U49395   7.44E−05   0.000106   0.001916   0.169175   P2RX5       M23379   7.44E−05   0.000106   3.22E−05   0.42571   RASA1       AF034176   7.44E−05   0.000106   0.000333   0.332105       AJ012755   7.44E−05   0.000106   0.000296   0.26445       AB007934   7.44E−05   0.000119   6.08E−06   0.345799   ACF7       M80899   7.44E−05   0.000119   2.48E−05   0.419409   AHNAK       AB014529   7.44E−05   0.000119   1.84E−05   0.43403   AKAP11       U37547   7.44E−05   0.000119   6.74E−06   −0.71736   BIRC2       U72649   7.44E−05   0.000119   0.000207   −0.30079   BTG2       D49738   7.44E−05   0.000119   0.000136   0.292742   CKAP1       AJ006267   7.44E−05   0.000119   7.19E−06   0.427023   CLPX       W28167   7.44E−05   0.000119   1.16E−05   0.214921   COPS7A       U18300   7.44E−05   0.000119   2.43E−06   0.183171   DDB2       AI133727   7.44E−05   0.000119   1.43E−06   0.181464   FLB6421       AA526812   7.44E−05   0.000119   0.000106   0.259476   FLJ10326       D64142   7.44E−05   0.000119   1.66E−05   0.528036   H1FX       U60319   7.44E−05   0.000119   0.001064   0.194324   HFE       M17017   7.44E−05   0.000119   1.43E−06   −1.74073   IL8       D32053   7.44E−05   0.000119   0.003279   0.222661   KARS       AB007914   7.44E−05   0.000119   7.13E−05   0.302838   KIAA0445       U10485   7.44E−05   0.000119    7.4E−06   0.270352   LRMP       U29656   7.44E−05   0.000119   4.31E−06   0.471876   NME3       AB014604   7.44E−05   0.000119   1.72E−05   0.425787   OSBPL3       U41745   7.44E−05   0.000119   0.00204   0.230274   PDAP1       S90469   7.44E−05   0.000119   5.56E−06   −0.2636   POR       M26683   7.44E−05   0.000119    3.7E−06   −0.16179   SCYA2       X81789   7.44E−05   0.000119   2.23E−05   0.143079   SF3A3       L14595   7.44E−05   0.000119   3.55E−05   −0.1953   SLC1A4       AL079286   7.44E−05   0.000119   0.000245   0.165851   STAU2       AA845349   7.44E−05   0.000119   7.78E−07   0.457176   TRIP7       X59303   7.44E−05   0.000119   0.000124   0.224891   VARS2       AB023219   7.44E−05   0.000119   1.41E−05   0.316475       M58603   7.44E−05   0.000129   9.08E−06   −0.56835   NFKB1       X77723   7.44E−05   0.000129   0.006788   −0.24317   RAB5EP       AF117829   7.44E−05   0.000129   2.61E−06   −0.57516   RIPK2       U52960   7.44E−05   0.000129   0.001042   −0.24648   SURB7       U84011   0.00482   0.000149   0.000134   0.286331   AGL       U90552   0.000344   0.000149   0.000182   0.288509   BTN3A1       M16336   0.00482   0.000149   0.000224   0.218007   CD2       U03106   0.000344   0.000149   0.000252   −0.87784   CDKN1A       AB009285   0.001377   0.000149   0.000137   0.235726   CFDP1       U63289   0.001377   0.000149   0.001722   −0.43517   CUGBP1       AF000430   0.00482   0.000149   0.000694   −0.19887   DNM1L       L11329   0.001377   0.000149   0.000142   −0.56584   DUSP2       AB007619   0.00482   0.000149   0.002073   0.198391   EBAG9       X81625   0.00482   0.000149   6.92E−05   −0.80689   ETF1       AL050128   0.000344   0.000149   1.81E−05   0.459416   FAM8A1       L49169   0.001377   0.000149   8.18E−05   −2.09549   FOSB       L25665   0.000344   0.000149   3.34E−06   −0.4513   GNL1       AI494623   0.00482   0.000149   0.000304   0.187206   HCDI       D89678   0.001377   0.000149   3.03E−05   0.197298   HNRPDL       U07563   0.000344   0.000149   1.02E−05   −0.23627   HSABLGR3       W28589   0.00482   0.000149   0.000129   0.170457   HSPD1       N29665   0.000344   0.000149   3.34E−05   0.593294   KIAA0618       AB023207   0.000344   0.000149   8.64E−06   −0.4056   KIAA0990       AL079277   0.00482   0.000149   0.000161   0.200656   LOC54103       Z14138   0.001377   0.000149   0.000197   −0.85008   MAP3K8       N23137   0.001377   0.000149   4.12E−06   0.244083   MPHOSPH9       AF050640   0.001377   0.000149   6.03E−05   0.324021   NDUFS2       AF069987   0.001377   0.000149   4.44E−05   0.203382   NIT1       AF043325   0.000344   0.000149   1.06E−05   0.328186   NMT2       M10901   0.001377   0.000149   1.91E−05   −0.58982   NR3C1       M12267   0.000344   0.000149   4.07E−06   −0.3279   OAT       U02882   0.00482   0.000149   0.000223   −0.99878   PDE4D       AF059531   0.000344   0.000149   6.73E−06   0.546441   PRMT3       M29893   0.001377   0.000149   9.96E−05   −0.15688   RALA       AB029028   0.001377   0.000149   9.11E−06   0.482258   RAP140       AB007448   0.00482   0.000149   0.000777   −0.319   SLC22A4       D87969   0.00482   0.000149   0.001578   0.401991   SLC35A1       U66615   0.00482   0.000149   0.000196   0.235993   SMARCC1       U46691   0.00482   0.000149   1.48E−05   −0.85179   SUPT6H       AF049910   0.00482   0.000149   0.000373   −0.32787   TACC1       X14787   0.001377   0.000149   2.88E−05   −0.19161   THBS1       AI375913   0.00482   0.000149   0.000905   −0.12102   TOP2A       X02344   0.001377   0.000149   0.00414   −0.20405   TUBB2       AF104421   0.000344   0.000149    6.5E−06   0.349373   UROD       J03258   0.000344   0.000149   1.21E−06   −0.58295   VDR       M58297   0.000344   0.000149   1.57E−05   0.185829   ZNF42       Y11681   0.000344   0.000149   1.92E−05   0.234481       AF104942   0.001377   0.00019   4.83E−05   0.464438   ABCC5       L07261   0.000344   0.00019   0.003564   0.29763   ADD1       L19871   0.001377   0.00019   0.000105   −0.19867   ATF3       J04027   0.000344   0.00019   0.000133   −0.42466   ATP2B1       M83363   0.001377   0.00019   0.004471   0.177565   ATP2B4       AF038195   0.000344   0.00019   0.000134   0.281425   BCS1L       S78771   0.001377   0.00019   0.000145   −0.24109   BRD2       L07044   0.001377   0.00019   0.000284   0.186013   CAMK2G       M28170   0.000344   0.00019   2.96E−05   0.356602   CD19       Y08682   0.000344   0.00019   0.000118   0.17398   CPT1B       AF046059   0.001377   0.00019   0.000665   0.204072   CREME9       L06797   0.001377   0.00019   0.000455   −0.93505   CXCR4       L39874   0.000344   0.00019   0.000354   0.353702   DCTD       AC004475   0.000344   0.00019   2.86E−05   0.25205   DKFZP434E2216       AI538172   0.001377   0.00019   0.000621   0.243057   DKFZp761B2423       AF010187   0.000344   0.00019     1E−05   0.361895   FIBP       AW051579   0.000344   0.00019   0.000258   0.390285   FLJ10512       M22632   0.001377   0.00019   1.34E−05   0.157239   GOT2       X59372   0.001377   0.00019   0.000528   −0.12959   HOXD9       X12433   0.000344   0.00019   1.07E−05   −0.39946   HS1-2       X15183   0.000344   0.00019   0.000645   −0.22973   HSPCA       AI912041   0.001377   0.00019   5.21E−05   −0.38517   HSPE1       X75315   0.000344   0.00019   0.010841   −0.64335   HSRNASEB       L42324   0.000344   0.00019   0.000262   −0.31758   HUMFRCG       X69433   0.001377   0.00019   0.002925   0.209735   IDH2       Y00093   0.000344   0.00019    2.6E−05   −0.39318   ITGAX       M88458   0.001377   0.00019   0.002031   −0.15998   KDELR2       AB011114   0.000344   0.00019   3.13E−05   0.278271   KIAA0542       AB011135   0.000344   0.00019   0.000149   0.247752   KIAA0563       U57721   0.001377   0.00019   3.47E−05   −0.23188   KYNU       Y11395   0.001377   0.00019   8.58E−05   0.34059   LANCL1       AI652660   0.000344   0.00019   2.28E−05   0.385107   LOC51112       AB026118   0.001377   0.00019   4.47E−06   −0.24886   MALT1       AB011144   0.000344   0.00019   9.36E−05   0.26851   MCM3AP       AI620381   0.000344   0.00019   8.06E−06   0.29605   MGC3077       AI525633   0.000344   0.00019   2.44E−05   0.170916   MGC5576       X16396   0.000344   0.00019   3.27E−06   −0.6151   MTHFD2       V00568   0.000344   0.00019   0.000769   0.549224   MYC       AL050281   0.000344   0.00019   2.85E−06   0.30517   NAG       AI985272   0.000344   0.00019   0.000474   −0.2571   NMB       D38524   0.000344   0.00019   0.001313   0.228851   NT5B       AJ225089   0.000344   0.00019   0.000531   −0.2589   OASL       Z82200   0.000344   0.00019   0.000136   −0.28579   P2Y10       X63564   0.001377   0.00019    1.7E−05   −0.28202   POLR2A       S57501   0.001377   0.00019   0.002179   0.267744   PPP1CA       X07109   0.000344   0.00019   0.000694   0.167774   PRKCB1       M28209   0.000344   0.00019   0.000392   −0.52456   RAB1       M87339   0.000344   0.00019   3.41E−05   0.248151   RFC4       Z14000   0.000344   0.00019   3.91E−06   −0.33734   RING1       X06815   0.000344   0.00019    3.5E−05   0.293968   SNRP70       L23959   0.000344   0.00019   1.82E−05   −0.36834   TFDP1       AB018262   0.000344   0.00019   0.000241   0.319056   TOMM70A       X00437   0.001377   0.00019   0.00022   0.248344   TRB@       AF061016   0.000344   0.00019   0.000264   0.349913   UGDH       U62392   0.000344   0.00019   2.74E−05   −0.65983   ZNF193       X78925   0.001377   0.00019   0.001253   −0.28003   ZNF267       AI655015   0.001377   0.00019   0.00444   0.74681       AL049387   0.001377   0.00019   5.12E−06   0.379296       AL050376   0.000344   0.00019   0.00026   0.410405       AB008775   0.000344   0.000304   1.88E−06   −0.80745   AQP9       AI141670   0.000344   0.000304    1.6E−06   −0.2494   CLCN2       AL080071   0.000344   0.000304   3.12E−06   0.237367   DKFZP564M082       AB028964   0.000344   0.000304   5.07E−05   0.351352   KIAA1041       M16801   0.001377   0.000304   0.000458   0.412733   NR3C2       N36842   0.001377   0.000304   0.000577   0.172944   UPF3A       AL096752   0.000344   0.000304   0.000323   −0.20419       U76421   0.000344   0.000402   0.000278   0.226301   ADARB1       L13939   0.001377   0.000402   0.000215   0.180874   AP1B1       X97074   0.001377   0.000402   0.001924   0.298218   AP2S1       U72936   0.000344   0.000402   1.03E−05   0.356824   ATRX       X94910   0.000344   0.000402   0.000204   0.249294   C12orf8       U18291   0.000344   0.000402   2.45E−05   0.594377   CDC16       L22005   0.001377   0.000402   0.000111   −0.15257   CDC34       M59287   0.00482   0.000402   0.000276   −0.72279   CLK1       U25435   0.000344   0.000402   0.000648   0.264876   CTCF       L39874   0.000344   0.000402   2.41E−05   0.211923   DCTD       X52104   0.000344   0.000402   0.000159   0.317963   DDX5       AL050062   0.000344   0.000402   0.000377   0.36401   DKFZP566K023       AL080081   0.00482   0.000402   0.000103   −0.60871   DNAJB9       X63741   0.001377   0.000402   0.000175   −0.59207   EGR3       D13988   0.001377   0.000402   0.000371   0.14676   GDI2       M27492   0.000344   0.000402   2.01E−06   −0.32619   IL1R1       S66213   0.000344   0.000402   9.56E−05   0.247863   ITGA6       AJ005896   0.000344   0.000402   5.38E−05   0.210462   JM4       Y10745   0.00482   0.000402   6.39E−05   −0.30524   KCNJ15       AB002374   0.00482   0.000402   0.000916   0.20284   KIAA0376       AB007874   0.001377   0.000402   0.000181   −0.21662   KIAA0414       AB011133   0.00482   0.000402   0.000521   0.302843   KIAA0561       AB018335   0.00482   0.000402   9.03E−05   0.234274   KIAA0792       M13452   0.00482   0.000402   0.00148   −0.28339   LMNA       X68836   0.00482   0.000402   2.15E−05   −0.57967   MAT2A       U79256   0.000344   0.000402   2.24E−05   0.328028   MGC14258       X76538   0.001377   0.000402   5.62E−05   0.408464   MPV17       AB011093   0.000344   0.000402   0.000101   0.612928   P114-RHO-GEF       X66363   0.001377   0.000402    6.8E−05   −0.24041   PCTK1       U13695   0.00482   0.000402   2.31E−05   0.31531   PMS1       D87078   0.000344   0.000402   3.88E−05   0.497225   PUM2       Z97074   0.001377   0.000402   3.97E−05   0.296662   RAB9P40       X90530   0.000344   0.000402   3.52E−05   0.254197   RAGB       U75679   0.001377   0.000402   0.000139   −0.29594   SLBP       AF007142   0.000344   0.000402   3.15E−06   0.678734       AL021977   0.00482   0.000402   8.82E−05   −0.82538       AL080192   0.001377   0.000402   4.26E−05   0.201319       HG1980-HT2023   0.00482   0.000402   0.003775   −0.48359       U47924   0.001377   0.000402   0.000134   0.52195       U83661   0.000344   0.000444   9.97E−06   0.270218   ABCC5       AI961929   0.000344   0.000444   1.88E−05   0.461528   ARHGAP1       X78817   0.000344   0.000444   2.82E−05   0.281835   ARHGAP4       AL080164   0.000344   0.000444   0.000218   0.268161   DKFZP564C1940       X90392   0.000344   0.000444   0.000208   0.150242   DNASE1L1       AI561196   0.000344   0.000444   0.000156   0.302434   FLJ11806       AJ008112   0.000344   0.000444   0.000246   −0.32126   FMNL       M94630   0.000344   0.000444   0.000244   0.274532   HNRPD       M38180   0.000344   0.000444   0.003037   −0.15741   HSD3B1       U79274   0.000344   0.000444   9.67E−05   0.285563   HSU79274       AB014585   0.000344   0.000444   6.48E−05   0.460196   KIAA0685       AB029001   0.000344   0.000444   0.000183   −0.33324   KIAA1078       AA045160   0.000344   0.000444   4.62E−05   0.179556   MRPS14       M96824   0.000344   0.000444   2.18E−05   0.139326   NUCB1       Y10055   0.000344   0.000444   9.91E−06   0.176067   PIK3CD       Z54367   0.000344   0.000444    1.3E−05   −0.39738   PLEC1       AF014402   0.000344   0.000444   7.63E−05   0.147061   PPAP2A       M30773   0.000344   0.000444   0.001161   0.41229   PPP3R1       M29386   0.000344   0.000444   6.26E−05   −0.23554   PRL       X02910   0.000344   0.000444   0.001378   −0.17579   TNF       S76792   0.000344   0.000444   0.000211   −0.16737   TNFRSF4       Y09008   0.000344   0.000444   0.000352   0.168444   UNG       U18009   0.000344   0.000444   0.002896   0.204706   VATI       D14533   0.000344   0.000444   0.000837   0.246085   XPA       W27419   0.000344   0.000444   2.83E−05   −0.44121       Z85986   0.000344   0.000444   0.000407   −0.2149       Z99716   0.000344   0.000444   5.14E−05   0.324642       U50939   0.001377   0.000525   1.19E−05   0.235552   APPBP1       Y15521   0.00482   0.000525   0.000492   −0.28889   ASMTL       J05682   0.00482   0.000525   0.000291   −0.33004   ATP6C       D26362   0.00482   0.000525   0.000707   0.247252   BRD3       AL120687   0.001377   0.000525   1.21E−05   −0.55731   CSH1       U20350   0.00482   0.000525   0.010386   0.383475   CX3CR1       X04011   0.00482   0.000525   0.000154   0.348439   CYBB       U78524   0.001377   0.000525   6.56E−05   −0.36872   DDXBP1       U87947   0.001377   0.000525   5.05E−05   −0.29673   EMP3       AL035252   0.00482   0.000525   0.003735   0.074075   ENTPD6       X04828   0.00482   0.000525   0.0015   0.256297   GNAI2       X56841   0.001377   0.000525   4.37E−05   0.338907   HLA-E       D49410   0.00482   0.000525   0.00016   −0.21753   HUMIL3RA12       L40586   0.00482   0.000525   3.02E−05   −0.20891   IDS       X52015   0.00482   0.000525   0.00032   −0.54051   IL1RN       D31888   0.00482   0.000525    7.5E−06   −0.44687   KIAA0071       D42047   0.001377   0.000525    3.5E−05   0.226884   KIAA0089       AB007958   0.00482   0.000525   0.00023   0.259725   KIAA0489       AB011100   0.00482   0.000525   0.000193   0.418151   KIAA0528       AB014553   0.00482   0.000525   0.002002   −0.25439   KIAA0653       AI888084   0.001377   0.000525   3.57E−05   0.391754   KIAA1624       X61118   0.00482   0.000525   0.001631   0.292879   LMO2       AJ004832   0.00482   0.000525   0.001715   0.30393   NTE       AB020631   0.001377   0.000525   0.000212   0.379354   PCF11       AB002359   0.00482   0.000525   2.36E−05   0.271468   PFAS       AB012229   0.001377   0.000525   0.000168   −0.59579   PFKFB3       M83088   0.001377   0.000525    3.5E−05   0.439367   PGM1       X84908   0.001377   0.000525   2.25E−05   0.331887   PHKB       U48250   0.001377   0.000525   8.51E−05   −0.2234   PRKCBP2       AB007851   0.000344   0.000525   1.95E−05   0.481768   PRPSAP2       X97267   0.00482   0.000525   0.000303   0.211707   PTPRCAP       M64595   0.00482   0.000525   0.004436   0.170959   RAC2       S59049   0.001377   0.000525   0.000915   −0.61362   RGS1       AL050267   0.00482   0.000525   0.000204   0.311003   SAMHD1       W28498   0.00482   0.000525    1.7E−05   −0.57386   SAR1       W27050   0.00482   0.000525   2.37E−05   −0.587   SFPQ       X92762   0.00482   0.000525   0.000116   0.283179   TAZ       U18422   0.001377   0.000525   0.000279   −0.14486   TFDP2       D87127   0.001377   0.000525   0.000126   −0.32216   TLOC1       U12595   0.001377   0.000525   1.07E−05   0.347309   TRAP1       AF046024   0.00482   0.000525   0.000469   0.405378   UBE1C       AF032456   0.001377   0.000525   5.89E−05   0.269833   UBE2G2       Y09723   0.00482   0.000525   0.000854   −0.23772   ZNF151       AL031778   0.00482   0.000525   0.000239   0.178561       AL049218   0.00482   0.000525   0.001951   0.238837       AL080216   0.00482   0.000525   0.000349   0.311531       L00352   0.00482   0.000525   0.005084   −0.39882       S79267   0.00482   0.000525   0.000908   −0.19945       U94902   0.00482   0.000525   0.002556   −0.17833       AA206524   0.000344   0.000567   0.000172   0.161868   BART1       AA926959   0.000344   0.000567   8.47E−05   0.169915   CKS1       M27543   0.000344   0.000567   0.000319   −0.48924   GNAI3       AF019386   0.000344   0.000567   0.000399   −0.18103   HS3ST1       AB006537   0.000344   0.000567   0.000658   −0.1547   IL1RAP       AJ001306   0.000344   0.000567    5.7E−05   0.338818   INADL       AB011116   0.000344   0.000567   0.000355   0.25593   KIAA0544       AB029014   0.000344   0.000567   0.001352   −0.1261   KIAA1091       AB029027   0.000344   0.000567   0.00209   0.180974   KIAA1104       M10901   0.000344   0.000567     4E−05   −0.42455   NR3C1       D30036   0.000344   0.000567   5.62E−05   −0.15539   PITPN       U47077   0.000344   0.000567   0.001173   0.30799   PRKDC       AF006751   0.000344   0.000567    3.4E−05   −0.23462   RRBP1       AB006198   0.000344   0.000567   0.001465   0.256734   SART1       D63780   0.000344   0.000567   0.00021   0.374406   STK25       W28892   0.000344   0.000567   8.26E−05   0.803602   SUI1       M74524   0.000344   0.000567   0.000421   −0.31531   UBE2A       AL031230   0.000344   0.000567   6.83E−05   0.272378       AF057160   0.001377   0.000588   0.000279   0.307281   ADPRTL1       M74491   0.001377   0.000588   3.02E−05   0.170825   ARF3       AL120559   0.001377   0.000588    4.8E−05   −0.64478   ARPP-19       D13630   0.001377   0.000588   3.01E−05   −0.42457   BZAP45       U83246   0.001377   0.000588   0.003502   0.133045   CPNE1       AL050390   0.001377   0.000588   0.000139   0.231898   DKFZP564O043       D13315   0.001377   0.000588   0.000203   0.371377   GLO1       H12458   0.001377   0.000588   5.42E−05   −0.22578   H12458 yj12d03.s1       AI347088   0.001377   0.000588   0.000151   0.321012   HMG17L3       X59770   0.001377   0.000588   0.001417   −0.36292   IL1R2       AB007855   0.000344   0.000588   1.02E−05   0.086396   KIAA0395       AB016816   0.001377   0.000588   0.000751   0.146218   MASL1       U07132   0.001377   0.000588   0.002035   −0.27336   NR1H2       AB019409   0.001377   0.000588   0.001479   0.154377   PDL-108       AB020641   0.001377   0.000588   0.00342   0.174568   PFTK1       AL050259   0.001377   0.000588   0.001864   0.272972   RAB2L       AA099265   0.001377   0.000588   0.000614   0.38275   RECK       X75042   0.001377   0.000588   6.85E−05   −0.39572   REL       AL050290   0.001377   0.000588   0.002426   −0.28771   SAT       AJ006417   0.001377   0.000588   0.000125   −0.18595   TBCD       X02812   0.001377   0.000588   1.78E−05   −0.16423   TGFB1       AL050262   0.001377   0.000588   0.0031   0.348226   TLR1       X16576   0.001377   0.000588   9.49E−05   0.431692   ZNF46       X91249   0.000344   0.000609   1.04E−05   −0.3925   ABCG1       Y00486   0.000344   0.000609   0.000297   0.259418   APRT       U10473   0.000344   0.000609   0.000103   −0.15424   B4GALT1       AB014595   0.000344   0.000609   5.19E−05   0.320955   CUL4B       Y15227   0.000344   0.000609   4.08E−05   0.222481   DLEU1       U85267   0.000344   0.000609   0.000131   0.142894   DSCR1       AB019036   0.000344   0.000609   0.000336   0.177649   GGPS1       U90313   0.000344   0.000609   0.001838   −0.25377   GSTTLp28       L42243   0.000344   0.000609   0.000201   0.403838   HUMIFNAM08       X16983   0.000344   0.000609   0.000317   0.232935   ITGA4       AB002368   0.000344   0.000609   0.001709   0.215217   KIAA0370       AI521453   0.000344   0.000609   0.000707   −0.22735   PC4       Y08110   0.000344   0.000609   9.87E−05   0.260436   SORL1       D38122   0.000344   0.000609   6.27E−05   −0.61781   TNFSF6       U49278   0.000344   0.000609   0.000173   0.204424   UBE2V1       X99050   0.000344   0.000609   7.72E−05   0.289751   UVRAG       Z93930   0.000344   0.000609   0.00015   −0.26558   XBP1       AF015767   0.000344   0.000659   0.000199   0.578977   BRE       M34677   0.000344   0.000659   0.000647   0.198622   F8A       J00210   0.000344   0.000659   0.002453   −0.18828   IFNA1       AJ007583   0.000344   0.000659   0.00506   −0.12644   LARGE       M36881   0.000344   0.000659   0.000302   0.328248   LCK       X70326   0.000344   0.000659   0.000132   −0.58974   MACMARCKS       M64571   0.000344   0.000659   0.000158   0.157573   MAP4       AI345944   0.000344   0.000659   0.000363   0.311507   NDUFB1       D23662   0.000344   0.000659   0.000171   0.289452   NEDD8       M14630   0.000344   0.000659   1.26E−05   −0.1626   PTMA       D64015   0.000344   0.000659   0.001012   0.195679   TIAL1       M63582   0.000344   0.000659   2.66E−05   −0.39175       U79300   0.000344   0.000659   0.000196   −0.16218       D29805   0.00482   0.000812   0.000289   −0.23044   B4GALT1       U47414   0.001377   0.000812   0.000137   0.262974   CCNG2       L33930   0.001377   0.000812   5.56E−06   0.343203   CD24       AL050164   0.00482   0.000812   0.000345   0.307729   CDYL       D10040   0.001377   0.000812   1.49E−05   −0.45708   FACL2       M36820   0.00482   0.000812   7.67E−05   −0.49075   GRO2       U77948   0.00482   0.000812   0.000511   0.286776   GTF2I       X56681   0.00482   0.000812   0.000503   −0.18359   JUND       AF070569   0.00482   0.000812   0.000446   −0.6104   MGC14376       W28205   0.00482   0.000812   0.00017   −0.21741   MKLN1       U61981   0.001377   0.000812   0.000725   0.203996   MSH3       AB014547   0.001377   0.000812   7.73E−05   0.217806   MTMR4       AL050366   0.00482   0.000812   0.001126   0.421541   OGT       U89606   0.001377   0.000812   6.13E−05   −0.19512   PDXK       D10495   0.00482   0.000812   0.000433   0.290156   PRKCD       D42063   0.001377   0.000812   0.000346   −0.52828   RANBP2       H68340   0.00482   0.000812   0.004081   −0.3419   RNAHP       AF059617   0.001377   0.000812   0.00012   −0.27807   SNK       AB028950   0.00482   0.000812   0.000365   0.313606   TLN1       L41690   0.001377   0.000812   0.000109   0.401776   TRADD       X95384   0.00482   0.000812   0.00053   0.327055   UK114       X98054   0.00482   0.001094   4.71E−05   −0.12615   CREBL1       J05036   0.00482   0.001094   0.00171   0.064463   CTSE       AF001434   0.00482   0.001094   0.000161   −0.26223   EHD1       L18960   0.00482   0.001094   3.26E−05   −0.38369   EIF1A       AB014555   0.00482   0.001094   0.001608   −0.18202   KIAA0655       X76057   0.00482   0.001094   0.000352   0.193745   MPI       X74594   0.00482   0.001094   0.000352   0.439326   RBL2       AF044309   0.00482   0.001094   0.000217   −0.2163   STX11       U07158   0.00482   0.001094   0.000122   −0.2301   STX4A       L40386   0.00482   0.001094   7.97E−05   −0.19863   TFDP2       H97470   0.00482   0.001094   0.000624   −0.10587       U78027   0.00482   0.001094   0.000804   0.340784       U50534   0.001377   0.001345   0.00039   0.250627   13CDNA73       X55330   0.001377   0.001345    9.3E−05   0.493025   AGA       L19605   0.001377   0.001345   0.004442   0.183134   ANXA11       Y00097   0.001377   0.001345   4.42E−05   0.409932   ANXA6       U26455   0.00482   0.001345   0.000705   0.499049   ATM       AF047473   0.001377   0.001345   5.14E−05   0.226   BUB3       M95724   0.00482   0.001345   0.002166   −0.46553   CENPC1       AB014558   0.001377   0.001345   0.004662   −0.44793   CRY2       R38263   0.001377   0.001345   0.00048   −0.12843   DJ347H13.4       AI434146   0.001377   0.001345   0.000397   0.187485   DKFZp570I0164       D12686   0.00482   0.001345   0.008744   −0.11456   EIF4G1       AF059611   0.00482   0.001345   0.000694   −0.27343   ENC1       X59834   0.001377   0.001345   0.004986   −0.34836   GLUL       D64142   0.001377   0.001345   0.000169   0.293999   H1FX       U51333   0.001377   0.001345   0.000376   0.273402   HK3       M59488   0.001377   0.001345   0.001357   −0.13313   HUMS100B3       X58529   0.001377   0.001345   0.000417   1.04789   IGHM       D79983   0.001377   0.001345   2.97E−05   0.387491   KIAA0161       AB002370   0.00482   0.001345   0.00052   0.425557   KIAA0372       AB007863   0.001377   0.001345   0.000128   0.29668   KIAA0403       AB014549   0.001377   0.001345   0.001505   0.42387   KIAA0649       AB020711   0.00482   0.001345   0.002079   0.222346   KIAA0904       AB002357   0.001377   0.001345   0.001045   0.317849   KIF3B       U09284   0.00482   0.001345   0.000792   −0.23635   LIMS1       D50810   0.001377   0.001345   5.17E−05   −0.1859   LNPEP       U18259   0.001377   0.001345   0.000153   0.229322   MHC2TA       AF041080   0.00482   0.001345   0.001964   0.367098   MN7       X70991   0.001377   0.001345   0.00203   −0.14032   NAB2       AC002045   0.00482   0.001345   0.00028   0.326033   NPIP       U92538   0.001377   0.001345   0.00149   0.2372   ORC5L       U24153   0.001377   0.001345   0.00018   −0.36291   PAK2       Z49194   0.001377   0.001345   0.000519   0.215733   POU2AF1       AF016371   0.001377   0.001345   0.001059   0.240562   PPIH       AF020736   0.001377   0.001345   6.26E−05   −0.32893   PSMC4       D11327   0.001377   0.001345   0.00019   −0.74969   PTPN7       AF098799   0.00482   0.001345   0.001893   −0.3646   RANBP7       M22995   0.001377   0.001345   0.005586   0.270032   RAP1A       L11566   0.001377   0.001345   0.000291   0.17032   RPL18       U71364   0.001377   0.001345   0.000276   −0.24064   SERPINB9       X07834   0.00482   0.001345   0.000362   −0.21917   SOD2       X05839   0.001377   0.001345   0.000779   −0.20819   TGFB1       AB000509   0.001377   0.001345   3.63E−05   0.460686   TRAF5       U82130   0.001377   0.001345   4.69E−05   −0.36064   TSG101       L16842   0.001377   0.001345   0.001533   0.189597   UQCRC1       X51521   0.001377   0.001345   0.000379   −0.62845   VIL2       M86400   0.001377   0.001345   0.000132   −0.30595   YWHAZ       AF041259   0.001377   0.001345   0.001393   0.202001   ZNF217       AA977136   0.001377   0.001345   0.001953   0.095364       AI624038   0.001377   0.001345   0.001833   −0.16137       AL050148   0.00482   0.001345   0.000905   0.266795       HG2709-HT2805   0.001377   0.001345   0.000134   −0.22645       HG3227-HT3404   0.001377   0.001345   4.02E−05   −0.23244       M28225   0.00482   0.001345   0.001444   −0.95152       U80017   0.001377   0.001345   0.004917   0.171432       X55544   0.001377   0.001467   0.001049   −0.12406   ATF1       X52560   0.001377   0.001467   8.17E−05   −0.50375   CEBPB       AA044787   0.001377   0.001467   0.001147   0.289086   CNOT8       AF017790   0.001377   0.001467   6.88E−06   0.382661   HEC       D00749   0.001377   0.001467   0.000131   −0.10539   HUMCD7G3       AB007890   0.001377   0.001467   0.000838   0.200677   KIAA0430       L35251   0.001377   0.001467   0.000873   0.12909   MFAP3       AF098638   0.001377   0.001467   0.000684   −0.18761   RAB5EP       AB004857   0.001377   0.001467   0.000471   0.23048   SLC11A2       U53347   0.001377   0.001467   0.001367   −0.13658   SLC1A5       U04847   0.001377   0.001467   0.000403   0.117176   SMARCB1       M92843   0.001377   0.001467    3.3E−05   −1.37866   ZFP36       AF033199   0.001377   0.001467   0.00019   0.237743   ZNF204       AC004893   0.001377   0.001467   0.000617   −0.25759       AL050151   0.001377   0.001467   8.03E−06   −0.80887       U80770   0.001377   0.001467   0.006738   −0.12644       W27675   0.00482   0.001614   0.005157   0.468709   CDA02       AI056696   0.00482   0.001614   0.000665   0.215941   CETN3       AF062536   0.00482   0.001614   0.005001   0.197482   CUL1       D29643   0.00482   0.001614   0.0005   0.157183   DDOST       AA181196   0.00482   0.001614   0.000166   0.119162   FLJ11712       W07033   0.001377   0.001614   0.000136   0.347648   GMFG       Z18859   0.00482   0.001614   0.000684   0.181514   GNAT2       U83660   0.00482   0.001614   0.00114   0.136411   HSU83660       AA628946   0.00482   0.001614   0.002684   0.337197   KHSRP       D13626   0.00482   0.001614   0.005837   0.254138   KIAA0001       AB002340   0.00482   0.001614   0.002977   0.168464   KIAA0342       AB002353   0.001377   0.001614   0.000119   0.305921   KIAA0355       U32849   0.00482   0.001614   0.000272   0.345048   NMI       S79219   0.00482   0.001614   0.000119   0.167463   PCCA       L37127   0.00482   0.001614   0.010173   0.103446   POLR2J       M35416   0.00482   0.001614   0.001433   0.33505   RALB       X76061   0.00482   0.001614   0.000273   0.378113   RBL2       AF061741   0.00482   0.001614   0.004586   0.221278   SDR1       D31891   0.001377   0.001614   0.000819   0.161458   SETDB1       W26406   0.00482   0.001614   0.000479   0.300512   SIAH1       X84002   0.00482   0.001614   0.000699   0.143479   TAF2J       U81006   0.00482   0.001614   0.003151   0.255479   TM9SF2       U69108   0.00482   0.001614   0.000657   0.208286   TRAF5       S66666   0.00482   0.001614   0.002417   0.119478       U84388   0.00482   0.001719   0.000197   −0.18606   CRADD       L08069   0.00482   0.001719   0.001985   −0.31866   DNAJA1       U41514   0.00482   0.001719   9.38E−05   −0.44803   GALNT1       M69013   0.001377   0.001719   6.26E−05   −0.1948   GNA11       L11706   0.00482   0.001719   0.001422   −0.16675   LIPE       R92331   0.00482   0.001719   0.000198   −0.24196   MT1E       X64318   0.00482   0.001719   0.006253   −0.37391   NFIL3       X12458   0.00482   0.001719   0.001489   −0.33668   P3       M25393   0.00482   0.001719   0.000958   −0.23304   PTPN2       M59465   0.00482   0.001719   0.0002   −0.96074   TNFAIP3       AF084260   0.00482   0.001719   0.001063   −0.39491   TRIP15       HG2149-HT2219   0.00482   0.001719   0.001437   −0.14432       AB021663   0.00482   0.001963   0.00027   −0.13923   ATF5       AL080209   0.00482   0.001963   0.000337   0.437957   DKFZP586F2423       M34641   0.00482   0.001963   0.002352   −0.14552   FGFR1       AL096714   0.001377   0.001963   0.000469   0.224782   FLJ20113       AB011124   0.001377   0.001963   0.000101   −0.17709   KIAA0552       AB020633   0.001377   0.001963   0.00082   0.308616   KIAA0826       AB029020   0.001377   0.001963   0.00061   0.3824   KIAA1097       X76220   0.001377   0.001963   7.21E−05   0.444366   MAL       AF040964   0.00482   0.001963   0.001161   −0.54746   MGC4701       U91512   0.001377   0.001963   0.00035   −0.55826   NINJ1       U60325   0.00482   0.001963   0.000288   −0.14386   POLG       Z15108   0.001377   0.001963   0.000107   0.176424   PRKCZ       Y08262   0.001377   0.001963   0.000183   0.377974   SCA2       U30246   0.001377   0.001963   0.000209   −0.25952   SLC12A2       J04137   0.001377   0.001963   0.000641   −0.22175   SSA2       M38449   0.001377   0.001963   0.0004   −0.29059   TGFB1       AC005757   0.00482   0.001963   0.000169   0.387439       HG825-HT825   0.001377   0.001963   0.000553   −0.19964       AF047348   0.001377   0.002207   0.000292   0.202669   APBA2       AF053977   0.001377   0.002207   0.003143   0.134266   CDC23       AF083322   0.001377   0.002207   0.000344   0.272282   CEP1       AL050369   0.001377   0.002207   0.001224   0.241992   DKFZP566J153       D32257   0.001377   0.002207   0.000238   0.300058   GTF3A       M65217   0.001377   0.002207   0.000232   0.249614   HSF2       AB014574   0.001377   0.002207   0.000606   0.130056   KIAA0674       AB029023   0.001377   0.002207   0.000219   0.219428   KIAA1100       Z34975   0.001377   0.002207   8.88E−05   0.41432   LDLC       D83597   0.001377   0.002207   0.000136   0.249838   LY64       U09759   0.001377   0.002207   0.000842   0.330751   MAPK9       U59302   0.001377   0.002207   0.000241   0.309348   NCOA1       AJ005698   0.001377   0.002207   0.004173   0.139618   PARN       X54871   0.001377   0.002207   0.010035   0.119258   RAB5B       AL080198   0.001377   0.002207   0.002866   0.251598   RENT2       M74447   0.001377   0.002207   0.000444   0.093537   TAP2       J04973   0.001377   0.002207   0.011696   0.141705   UQCRC2       U90902   0.001377   0.002207   0.001336   0.246217       U94333   0.001377   0.002323   0.004818   −0.13898   C1QR       U60808   0.001377   0.002323   0.000374   −0.12217   CDS1       L08069   0.001377   0.002323   0.002161   −0.29982   DNAJA1       AA552140   0.001377   0.002323   0.003368   −0.22604   E2F4       M31210   0.001377   0.002323   0.000124   −0.33555   EDG1       AI189287   0.001377   0.002323   0.002445   −0.24115   H1F2       W25934   0.001377   0.002323   0.003385   −0.32382   JTV1       Z98046   0.001377   0.002323   0.000122   −0.33551   MAGED2       L76571   0.001377   0.002323   0.009985   −0.12617   NR0B2       AF071504   0.001377   0.002323   0.000191   −0.14267   STX11       X56687   0.001377   0.002323   0.00011   −0.29728   UBTF       AI097085   0.001377   0.002323   0.000941   −0.16209       AA114830   0.001377   0.002503   0.000293   0.272601   AKAP10       AI991631   0.001377   0.002503   0.000132   −0.11786   BRD4       U04343   0.001377   0.002503   4.45E−05   −0.25478   CD86       M12824   0.001377   0.002503   0.008271   −0.34597   CD8A       U89896   0.001377   0.002503   0.006997   −0.2182   CSNK1G2       AI432401   0.001377   0.002503   0.006072   0.32631   FGL2       AA176780   0.001377   0.002503   0.001296   0.14235   HSA249128       M21188   0.001377   0.002503   0.000165   0.251899   IDE       U43572   0.001377   0.002503   0.000128   0.318327   NAGLU       X02751   0.001377   0.002503   0.000359   −0.2229   NRAS       AF069250   0.001377   0.002503   0.00135   0.476217   OA48-18       D25328   0.001377   0.002503   0.000171   0.125335   PFKP       AF010312   0.001377   0.002503   0.001216   −0.47628   PIG7       M34668   0.001377   0.002503   0.000421   0.181315   PTPRA       AF061836   0.001377   0.002503   0.001026   0.21847   RASSF1       AI535653   0.001377   0.002503   0.001712   0.34571   SC4MOL       X75755   0.001377   0.002503   0.003813   −0.2236   SFRS2       W16505   0.001377   0.002503   0.001699   0.101763   SNRPD2       L31529   0.001377   0.002503   0.000325   0.144265   SNTB1       D86970   0.001377   0.002503   0.000219   0.218777   TIAF1       AL050223   0.001377   0.002503   0.002632   0.2458   VAMP2       AA877215   0.001377   0.002503   0.008439   −0.17878       AL049435   0.001377   0.002503   0.000111   0.194323       M76180   0.001377   0.002575   0.000698   0.162775   DDC       M94065   0.001377   0.002575   0.000426   0.156894   DHODH       J04988   0.001377   0.002575   6.17E−05   −0.22304   HSPCB       Z68907   0.001377   0.002575   0.000305   0.391111   IDH3G       J03909   0.001377   0.002575   0.000837   −0.35709   IFI30       AB011104   0.001377   0.002575   0.000729   0.227798   KIAA0532       AB011173   0.001377   0.002575   0.000585   0.283714   KIAA0601       U70322   0.001377   0.002575   0.000177   −0.41259   KPNB2       D86961   0.001377   0.002575   0.001925   −0.19403   LHFPL2       AF052111   0.001377   0.002575   0.000738   0.249468   LOC51172       AJ224875   0.001377   0.002575   0.005091   0.139606   MGC2840       M21985   0.001377   0.002575   0.001409   −0.102   NR2C1       J05448   0.001377   0.002575   0.004982   −0.15329   POLR2C       AB006572   0.001377   0.002575   0.000169   0.213636   RMP       AJ011712   0.001377   0.002575   0.011372   0.066711   TNNT1       AJ006973   0.001377   0.002575   0.000101   −0.31773   TOM1       U67122   0.001377   0.002575   0.000364   −0.14274   UBL1       U71598   0.001377   0.002575   0.003508   0.128607   ZNF274       M81118   0.001377   0.002575   0.00023   0.333526       U61166   0.001377   0.002575   0.003055   −0.14488       U94902   0.001377   0.002575   0.000137   −0.23298       Z82244   0.001377   0.002575   0.000258   −0.53938       M36341   0.001377   0.002788   0.00056   −0.38498   ARF4       L09159   0.001377   0.002788   0.00112   0.474985   ARHA       U68485   0.00482   0.002788   0.006797   0.224774   BIN1       Z22555   0.001377   0.002788   0.005455   −0.16351   CD36L1       D44497   0.00482   0.002788   0.004453   0.131654   CORO1A       L37042   0.00482   0.002788   0.000582   −0.33273   CSNK1A1       M74099   0.001377   0.002788   0.00014   0.389638   CUTL1       AL080159   0.001377   0.002788   0.002335   −0.11101   DKFZP434M154       AF004292   0.001377   0.002788   0.001306   −0.2375   DKFZP566C134       AF088982   0.001377   0.002788   0.001264   −0.22098   DNAJB5       U73704   0.001377   0.002788   0.001412   −0.17508   FAP48       M77810   0.00482   0.002788   0.000209   −0.15854   GATA2       U67369   0.00482   0.002788   0.00347   0.137095   GFI1       D00632   0.001377   0.002788   0.001138   −0.15517   GPX3       X99270   0.001377   0.002788   0.00065   0.191612   HSXQ28ORF       D42041   0.00482   0.002788   0.003705   0.195279   KIAA0088       AA524058   0.001377   0.002788   0.000288   0.360599   LOC51020       U77604   0.001377   0.002788   0.00233   0.296247   MGST2       J04031   0.00482   0.002788   0.000148   0.290038   MTHFD1       AF025794   0.001377   0.002788   0.006763   0.107466   MTRR       D86326   0.001377   0.002788   0.008217   0.124987   P115       U14417   0.001377   0.002788   0.000521   −0.13999   RALGDS       U85611   0.001377   0.002788   0.000126   −0.3879   SIP2-28       U66617   0.001377   0.002788   0.001462   −0.14653   SMARCD1       X59960   0.001377   0.002788   0.005127   −0.11069   SMPD1       AF031166   0.001377   0.002788   0.001219   0.110457   SRP46       U86136   0.001377   0.002788   0.000542   0.149235   TEP1       U16296   0.001377   0.002788   0.00138   0.136848   TIAM1       D50917   0.001377   0.002788   0.000467   0.402091   TRIP-Br2       AC004770   0.001377   0.002788   0.001042   −0.10615       J03071   0.001377   0.002788   0.0116   0.17732       D67031   0.00482   0.004163   0.000204   0.543743   ADD3       U68030   0.00482   0.004163   0.000279   −0.16075   CCR6       U41387   0.00482   0.004163   8.67E−05   −0.29576   DDX21       AF084535   0.00482   0.004163   0.002306   0.159095   EPM2A       AI417075   0.00482   0.004163   0.000538   0.330385   FLJ14040       D82348   0.00482   0.004349   0.006063   0.245422   ATIC       AA648295   0.00482   0.004349   0.002422   0.337484   CBX3       U79270   0.00482   0.004349   0.001345   0.460807   COX11       AF071748   0.00482   0.004349   0.002471   0.170315   CTSF       AL080088   0.00482   0.004349   0.000207   0.165357   DKFZP564K2062       AI540318   0.00482   0.004349   0.00055   −0.13789   DNAJB6       U03272   0.00482   0.004349   0.003893   0.101031   FBN2       Z97989   0.00482   0.004349   0.001126   −0.41969   FYN       AF042379   0.00482   0.004349   0.008308   0.176604   GCP2       U73737   0.00482   0.004349   0.00262   −0.14396   HUMMSH06       AF031167   0.00482   0.004349   0.000117   0.201914   IL15       D83778   0.00482   0.004349   0.000504   −0.2149   KIAA0194       AB028965   0.00482   0.004349   0.007277   0.125446   KIAA1042       M79321   0.00482   0.004349   0.003247   −0.21992   LYN       L11284   0.00482   0.004349   0.003994   −0.09508   MAP2K1       AJ000882   0.00482   0.004349   0.00042   0.180413   NCOA1       L41067   0.00482   0.004349   0.000388   0.370635   NFATC3       AF057297   0.00482   0.004349   0.001191   0.521103   OAZ2       X66360   0.00482   0.004349   0.001123   −0.17473   PCTK2       U24183   0.00482   0.004349   0.001156   0.141168   PFKM       L42373   0.00482   0.004349   0.006706   0.165885   PPP2R5A       AB018288   0.00482   0.004349   0.003777   0.184227   RANBP16       M58459   0.00482   0.004349   0.008923   −1.04752   RPS4Y       M60725   0.00482   0.004349   0.001349   −0.10092   RPS6KB1       Y10931   0.00482   0.004349   0.001246   0.194156   SPK       AB004904   0.00482   0.004349   0.000233   −0.31373   SSI-3       AF060798   0.00482   0.004349   0.000809   0.142845   STK16       U66867   0.00482   0.004349   0.011318   0.150812   UBE2I       AB028980   0.00482   0.004349   0.001471   0.265042   USP24       AF052107   0.00482   0.004349   0.002884   0.197902       AL031985   0.00482   0.004349   0.000181   −0.24089       D26121   0.00482   0.004349   0.00387   −0.16268       W28667   0.00482   0.004349   0.004391   0.476395       AL050157   0.00482   0.004467   0.000289   0.269949   DKFZPS86O0120       U31930   0.00482   0.004467   0.000244   0.349997   DUT       AI951946   0.00482   0.004467   8.71E−05   0.401112   HBOA       AB002354   0.00482   0.004467   0.001517   −0.13368   KIAA0356       M36067   0.00482   0.004467   8.15E−05   0.277858   LIG1       J02783   0.00482   0.004467   0.002151   −0.21979   P4HB       M37238   0.00482   0.004467   0.005333   −0.15474   PLCG2       M99438   0.00482   0.004467    6.2E−05   −0.36844   TLE3       Z97630   0.00482   0.004467   0.002794   0.217849       D14874   0.00482   0.005608   0.000611   −0.55358   ADM       L08177   0.00482   0.005608   0.000434   −0.49252   EBI2       U09510   0.00482   0.005608   5.27E−05   −0.57567   GARS       L05424   0.00482   0.005608   0.000114   −0.39048   HUMSCG19       X13956   0.00482   0.005608   0.004098   0.187622   MGC10471       U88620   0.00482   0.005608   0.00074   0.345628   OGG1       M29551   0.00482   0.005608   0.000471   0.319301   PPP3CB       AF068836   0.00482   0.005608   0.000323   −0.23628   PSCDBP       U08316   0.00482   0.005608   0.0006   0.205899   RPS6KA3       J02966   0.00482   0.005608   0.000498   −0.11291   SLC25A4       AF107463   0.00482   0.005608   0.002824   −0.36924   SPF30       AB000450   0.00482   0.005608   0.000256   −0.24717   VRK2       AF070590   0.00482   0.005608   0.000834   0.127523       AF001383   0.00482   0.006065   0.002075   0.16512   BIN1       AF026291   0.00482   0.006065   0.000385   −0.16859   CCT4       D63877   0.00482   0.006065   0.005226   −0.13956   KIAA0157       U14383   0.00482   0.006065   0.002623   −0.18669   MUC8       U68140   0.00482   0.006065   0.000677   0.172443   NVL       L25441   0.00482   0.006065   0.000613   −0.17207   PGGT1B       U46751   0.00482   0.006065   0.000578   −0.38675   SQSTM1       HG4740-HT5187   0.00482   0.006065   0.00867   0.146562       W26851   0.00482   0.006065   0.002052   0.312992       U78735   0.00482   0.006347   0.000529   −0.09197   ABCA3       Y12226   0.00482   0.006347   0.000397   −0.21303   AP1G1       D38293   0.00482   0.006347   0.002894   −0.24373   AP3M2       X14046   0.00482   0.006347   0.001084   0.134786   CD37       AF026004   0.00482   0.006347   0.008622   −0.07494   CLCN2       U46023   0.00482   0.006347   0.000273   −0.17969   CXorf6       AL080178   0.00482   0.006347   0.000683   0.260343   DKFZP434K171       AL080118   0.00482   0.006347   0.001904   −0.28696   DKFZP564F1123       AL050197   0.00482   0.006347   0.004294   0.233045   DKFZP586D0623       X68277   0.00482   0.006347   0.011411   −0.42385   DUSP1       X03674   0.00482   0.006347   0.008478   0.174463   G6PD       Y13286   0.00482   0.006347   0.004068   0.134985   GDI2       U19247   0.00482   0.006347   0.000589   −0.29688   HSINFGRA7       AB023163   0.00482   0.006347   0.002537   0.194491   HYPH       L36818   0.00482   0.006347   0.007182   0.204818   INPPL1       U51127   0.00482   0.006347   0.003952   0.108702   IRF5       M15395   0.00482   0.006347   0.001863   0.402323   ITGB2       U51336   0.00482   0.006347   0.008615   0.336527   ITPK1       AJ000008   0.00482   0.006347   0.000256   −0.14181   PIK3C2G       AI126004   0.00482   0.006347   0.000954   0.262925   SAS10       AF051325   0.00482   0.006347   0.000144   −0.43952   SH2D2A       U79528   0.00482   0.006347   0.002518   0.158101   SR-BP1       U52426   0.00482   0.006347   9.31E−05   0.411984   STIM1       AB018339   0.00482   0.006347   0.000751   0.199758   SYNE-1B       D43642   0.00482   0.006347   0.0005   0.305805   TCFL1       D29767   0.00482   0.006347   0.003934   −0.09702   TEC       M92383   0.00482   0.006347   0.001466   0.219769   TMSB10       AA192359   0.00482   0.006347   0.00028   0.17619   TRN-SR       AC004472   0.00482   0.006347   0.002169   −0.15115       AF052138   0.00482   0.006347   0.000189   0.441167       X15674   0.00482   0.006347   0.007899   −0.10738       Z82215   0.00482   0.006347   0.002527   0.153792       AF070523   0.00482   0.006634   0.00037   0.437983   JWA       D13641   0.00482   0.006634   0.000776   0.275308   KIAA0016       X79204   0.00482   0.006634   0.000182   0.256049   SCA1       AB015718   0.00482   0.006634   0.001172   0.202412   STK10       AF059575   0.00482   0.006634   0.000563   −0.18074       M74089   0.00482   0.006634   0.00076   0.187888       U44111   0.00482   0.006634   0.003845   0.105361       AJ243310   0.00482   0.006921   0.000945   −0.97643   C14orf3       W26854   0.00482   0.006921   0.011098   −0.13774   DKFZP434D156       U88629   0.00482   0.006921   0.001778   −0.16763   ELL2       M59830   0.00482   0.006921   0.000221   −1.12882   HSPA1B       M95929   0.00482   0.006921   0.004606   −0.34536   PMX1       M57399   0.00482   0.006921   0.010231   −0.14331   PTN       N25117   0.00482   0.006921   0.002068   −0.16335   RPS26       AL049940   0.00482   0.006921   0.001149   −0.42489   RYBP       U39318   0.00482   0.006921   0.001097   −0.24533   UBE2D3       Z29331   0.00482   0.006921   0.000193   −0.15851   UBE2H       M55682   0.00482   0.006921   0.010264   −0.10921       S58544   0.00482   0.006921   0.005501   −0.11193       L13687   0.00482   0.007311   0.002185   0.114008   ARL2       M88714   0.00482   0.007311   0.002075   0.114833   BDKRB2       AL050173   0.00482   0.007311   0.001866   0.128954   C21orf25       M33680   0.00482   0.007311   0.002612   0.134487   CD81       X05299   0.00482   0.007311   0.003837   0.171613   CENPB       X16832   0.00482   0.007311   0.000578   0.177395   CTSH       U83410   0.00482   0.007311   0.005207   0.219569   CUL2       AL050018   0.00482   0.007311   0.003938   0.220539   DKFZP564B116       AL080063   0.00482   0.007311   0.006562   0.186332   DKFZP564I052       AL050286   0.00482   0.007311   0.000767   0.221397   DKFZP586A011       X63692   0.00482   0.007311   0.003174   0.172997   DNMT1       AA522537   0.00482   0.007311   0.002762   0.113812   ELAC2       AI183417   0.00482   0.007311   0.006167   0.101739   GABPB1       X62534   0.00482   0.007311   0.000973   0.195089   HMG2       D50532   0.00482   0.007311   0.001268   0.159735   HML2       AJ006591   0.00482   0.007311   0.001379   0.1682   HSA6591       Y00796   0.00482   0.007311   0.000438   0.386166   ITGAL       AB018301   0.00482   0.007311   0.008701   0.138344   KIAA0758       AB020694   0.00482   0.007311   0.002526   0.205561   KIAA0887       AB023198   0.00482   0.007311   0.000409   0.275051   KIAA0981       AB028958   0.00482   0.007311   0.001533   0.117614   KIAA1035       U66711   0.00482   0.007311   0.006567   0.260368   LY6E       L13744   0.00482   0.007311   0.007658   0.19599   MLLT3       Y09631   0.00482   0.007311   0.000769   0.309898   PIBF1       L77213   0.00482   0.007311   0.001122   0.247214   PMVK       X73478   0.00482   0.007311   0.000681   0.242238   PPP2R4       U94319   0.00482   0.007311   0.000688   0.337656   PSIP2       U27516   0.00482   0.007311   0.000222   0.194938   RAD52       W25793   0.00482   0.007311   0.000438   0.258505   RNF3       X06617   0.00482   0.007311   0.002581   0.116631   RPS11       Z25749   0.00482   0.007311   0.001419   0.123333   RPS7       U80760   0.00482   0.007311   0.007371   0.161214   TNRC1       L27071   0.00482   0.007311   0.000638   0.372837   TXK       AL031427   0.00482   0.007311   0.000541   0.367004       L109722   0.00482   0.007311   0.00187   0.134304       X15675   0.00482   0.007311   0.011165   0.131908       AL050089   0.00482   0.007852   0.001906   −0.23061   BAZ1A       L22005   0.00482   0.007852   0.002439   −0.22532   CDC34       AB014679   0.00482   0.007852   0.003059   −0.13664   CHST2       X77956   0.00482   0.007852   0.000689   −0.22743   ID1       AI814466   0.00482   0.007852   0.001127   −0.1955   VAMP5       HG4074-HT4344   0.00482   0.007852   0.000964   −0.17461       AF005050   0.00482   0.008059   0.001761   0.230395   DNPEP       J03909   0.00482   0.008059   0.000125   −0.18353   IFI30       X59841   0.00482   0.008059   0.000226   0.265756   PBX3       AI819942   0.00482   0.009314   0.002286   0.326115   2-Sep       D86981   0.00482   0.009314   0.003441   0.319525   APPBP2       Y10805   0.00482   0.009314   0.002583   0.183496   HRMT1L2       U51127   0.00482   0.009314   0.00212   0.282678   IRF5       U14970   0.00482   0.009314   0.000561   0.144991   RPS5       AI813532   0.00482   0.009314   0.00037   −0.41933   TNFRSF1B       Y15228   0.00482   0.010363   0.002026   −0.17032   DLEU2       AA926957   0.00482   0.010363   0.000909   −0.22483   FLJ10534       AA554945   0.00482   0.010363   0.001827   −0.14301   FLJ10803       AJ001383   0.00482   0.010363   0.001968   −0.3226   LY94       M97676   0.00482   0.010363   0.010011   −0.16313   MSX1       AF002020   0.00482   0.010363   0.001278   −0.1736   NPC1       U25975   0.00482   0.010363   0.000764   −0.24651   PAK2       X66363   0.00482   0.010363   0.000837   −0.4179   PCTK1       D87957   0.00482   0.010363   0.004418   −0.14751   RQCD1       AI610467   0.00482   0.010363   0.000699   −0.17683   SMG1       AJ012008   0.00482   0.010363   0.002571   −0.32997       AJ012008   0.00482   0.010363   0.001638   −0.16204                  
 
     
       
         
           
               
             
               
                 TABLE II 
               
             
            
               
                   
               
               
                   
               
               
                 Gene Expression Profile from PBMCs of MS vs. Healthy-Highest 
               
               
                 Scoring Genes (Bonfferoni analysis) 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 TNOM 
                 Info 
                 t-Test 
                 Log 
                   
               
               
                 Identifier 
                 PValue 
                 PValue 
                 PValue 
                 FoldChange 
                 Symbol 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 AA203527 
                 1.37131E−05 
                 1.613E−06 
                 1.18E−07 
                 0.281992 
                 RPP20 
               
               
                 AA780049 
                 7.44428E−05 
                  2.35E−05 
                 7.39E−07 
                 0.54912 
                 FLJ21439 
               
               
                 AA845349 
                 7.44428E−05 
                 0.0001187 
                 7.78E−07 
                 0.457176 
                 TRIP7 
               
               
                 AA902713 
                 2.10971E−06 
                 1.993E−06 
                 1.44E−06 
                 0.474378 
               
               
                 AB002344 
                 7.44428E−05 
                 5.915E−05 
                 8.48E−07 
                 −1.00068 
                 KIAA0346 
               
               
                 AB002347 
                 2.10971E−06 
                 1.329E−07 
                 7.19E−10 
                 0.371731 
                 KIAA0349 
               
               
                 AB002348 
                 1.37131E−05 
                 3.861E−06 
                 2.49E−07 
                 0.576346 
                 KIAA0350 
               
               
                 AB002386 
                 2.10971E−06 
                 7.732E−07 
                 5.34E−09 
                 0.586117 
                 EZH1 
               
               
                 AB002448 
                 1.37131E−05 
                 5.009E−06 
                 2.45E−07 
                 0.468926 
               
               
                 AB007891 
                 1.37131E−05 
                 3.861E−06 
                 3.99E−05 
                 0.196376 
                 KIAA0431 
               
               
                 AB007895 
                 1.37131E−05 
                 5.009E−06 
                 9.61E−07 
                 0.186643 
                 KIAA0435 
               
               
                 AB007927 
                 2.10971E−06 
                 1.993E−06 
                 2.12E−07 
                 0.323787 
                 RERE 
               
               
                 AB007960 
                 2.10971E−06 
                 9.536E−07 
                 7.96E−06 
                 0.447772 
                 SH3GLB1 
               
               
                 AB008775 
                 0.000344298 
                 0.0003041 
                 1.88E−06 
                 −0.80745 
                 AQP9 
               
               
                 AB011004 
                 0.000344298 
                 7.048E−06 
                 1.41E−06 
                 −1.34073 
                 UAP1 
               
               
                 AB011108 
                 1.37131E−05 
                 5.045E−07 
                 4.39E−07 
                 0.453498 
                 PRP4 
               
               
                 AB011113 
                 1.37131E−05 
                 7.048E−06 
                 3.74E−07 
                 0.444795 
                 WDR7 
               
               
                 AB011115 
                 1.37131E−05 
                 5.045E−07 
                 3.39E−07 
                 0.382809 
                 KIAA0543 
               
               
                 AB011161 
                 2.57282E−08 
                 4.013E−09 
                 9.64E−11 
                 0.63432 
                 PIP5K1C 
               
               
                 AB014535 
                 1.37131E−05 
                 5.045E−07 
                 1.04E−06 
                 0.285282 
                 KIAA0635 
               
               
                 AB014538 
                 0.000344298 
                  4.67E−05 
                 1.98E−06 
                 −0.63923 
                 KIAA0638 
               
               
                 AB014579 
                 1.37131E−05 
                 5.009E−06 
                 6.08E−08 
                 0.367966 
                 MGEA5 
               
               
                 AB014608 
                 7.44428E−05 
                 9.644E−05 
                 4.59E−06 
                 0.41494 
                 KIAA0708 
               
               
                 AB015019 
                 7.44428E−05 
                 7.048E−06 
                 2.75E−07 
                 −0.24515 
                 BAIAP2 
               
               
                 AB018343 
                 1.83773E−09 
                 4.157E−10 
                 9.05E−12 
                 0.383078 
                 KIAA0800 
               
               
                 AB023153 
                 2.10971E−06 
                 1.329E−07 
                 1.82E−08 
                 0.895842 
                 KIAA0936 
               
               
                 AB023235 
                 7.44428E−05 
                 1.613E−06 
                 1.43E−05 
                 0.311216 
                 KIAA1018 
               
               
                 AB026118 
                 0.00137719 
                 0.0001897 
                 4.47E−06 
                 −0.24886 
                 MALT1 
               
               
                 AB026436 
                 7.44428E−05 
                 1.613E−06 
                 0.000219 
                 −0.7589 
                 DUSP10 
               
               
                 AB028951 
                 2.63714E−07 
                 1.715E−07 
                 8.78E−09 
                 0.543028 
                 KIAA1028 
               
               
                 AB028981 
                 2.10971E−06 
                 7.732E−07 
                 5.34E−07 
                 0.282288 
                 KIAA1058 
               
               
                 AB029015 
                 2.63714E−07 
                 2.488E−07 
                 5.37E−09 
                 0.695063 
                 PLCE2 
               
               
                 AB029038 
                 7.44428E−05 
                 1.613E−06 
                 7.62E−05 
                 0.364386 
                 KIAA1115 
               
               
                 AC002400 
                 1.37131E−05 
                  3.06E−05 
                 2.28E−06 
                 −0.25834 
                 UBPH 
               
               
                 AF000545 
                 7.44428E−05 
                 5.226E−05 
                 3.48E−06 
                 −0.85393 
                 P2Y10 
               
               
                 AF001294 
                 1.37131E−05 
                 7.048E−06 
                 1.23E−06 
                 −0.76359 
                 TSSC3 
               
               
                 AF004230 
                 2.63714E−07 
                 1.715E−07 
                 3.06E−07 
                 0.349166 
                 LILRB1 
               
               
                 AF005043 
                 7.44428E−05 
                 5.226E−05 
                  2.7E−06 
                 0.408592 
                 PARG 
               
               
                 AF007130 
                 2.10971E−06 
                 5.045E−07 
                 2.51E−06 
                 0.391811 
                 LOC54104 
               
               
                 AF007142 
                 0.000344298 
                 0.0004443 
                 3.15E−06 
                 0.678734 
               
               
                 AF007151 
                 1.37131E−05 
                 5.045E−07 
                 3.25E−06 
                 0.468343 
                 MMS19L 
               
               
                 AF010193 
                 7.44428E−05 
                  2.35E−05 
                 1.26E−07 
                 −1.4705 
                 MADH7 
               
               
                 AF010309 
                 1.37131E−05 
                 5.009E−06 
                 7.36E−07 
                 −0.28533 
                 PIG3 
               
               
                 AF012023 
                 7.44428E−05 
                 5.915E−05 
                 1.02E−06 
                 0.50623 
                 ICAP-1A 
               
               
                 AF014958 
                 2.10971E−06 
                 4.309E−06 
                 1.05E−07 
                 −0.42152 
                 CCRL2 
               
               
                 AF015553 
                 2.10971E−06 
                 9.536E−07 
                 2.61E−07 
                 0.61214 
                 GTF2I 
               
               
                 AF019083 
                 1.37131E−05 
                 5.009E−06 
                 8.34E−07 
                 0.17011 
                 PTENP1 
               
               
                 AF022375 
                 2.63714E−07 
                 8.227E−08 
                 1.87E−11 
                 −1.35847 
                 VEGF 
               
               
                 AF023614 
                 1.37131E−05 
                 1.511E−05 
                 4.79E−07 
                 −0.20744 
                 TACI 
               
               
                 AF024710 
                 8.54758E−11 
                 8.548E−11 
                 1.13E−12 
                 −1.95537 
                 VEGF 
               
               
                 AF026086 
                 0.000344298 
                  4.67E−05 
                 2.66E−06 
                 0.297942 
                 PEX1 
               
               
                 AF029777 
                 1.37131E−05 
                 7.048E−06 
                 8.27E−07 
                 0.290159 
                 GCN5L2 
               
               
                 AF030249 
                 1.37131E−05 
                 1.613E−06 
                 1.98E−07 
                 0.534547 
                 ECH1 
               
               
                 AF035281 
                 2.10971E−06 
                 2.484E−06 
                 4.87E−07 
                 0.472445 
               
               
                 AF038564 
                 1.37131E−05 
                 1.613E−06 
                 2.05E−07 
                 −0.40446 
                 ITCH 
               
               
                 AF040707 
                 2.10971E−06 
                 1.993E−06 
                 3.57E−07 
                 0.289845 
                 NPR2L 
               
               
                 AF042386 
                 1.37131E−05 
                 5.009E−06 
                 0.000107 
                 0.137192 
                 PPIE 
               
               
                 AF052160 
                 7.44428E−05 
                 1.511E−05 
                 1.67E−06 
                 0.623021 
               
               
                 AF054176 
                 2.10971E−06 
                 1.329E−07 
                 6.47E−09 
                 −0.58138 
                 C1orf7 
               
               
                 AF054589 
                 0.000344298 
                  2.35E−05 
                 1.98E−06 
                 0.945394 
               
               
                 AF061258 
                 7.44428E−05 
                 9.644E−05 
                 1.58E−06 
                 0.622201 
                 LIM 
               
               
                 AF067853 
                 1.37131E−05 
                 5.009E−06 
                 5.02E−06 
                 0.361707 
                 ADSL 
               
               
                 AF069517 
                 2.10971E−06 
                 1.329E−07 
                 4.91E−07 
                 0.399638 
                 RBM6 
               
               
                 AF070582 
                 2.63714E−07 
                 1.715E−07 
                 3.23E−08 
                 −0.19773 
                 MGC13033 
               
               
                 AF070606 
                 1.37131E−05 
                  3.06E−05 
                 1.48E−06 
                 −0.89337 
               
               
                 AF070617 
                 1.37131E−05 
                 3.861E−06 
                 3.23E−07 
                 0.323494 
               
               
                 AF077820 
                 2.63714E−07 
                 2.188E−08 
                 2.91E−08 
                 0.656852 
                 LRP5 
               
               
                 AF079167 
                 2.63714E−07 
                 2.488E−07 
                 7.37E−10 
                 −1.93249 
                 OLR1 
               
               
                 AF082557 
                 0.00137719 
                  4.67E−05 
                 2.23E−06 
                 0.226994 
                 TNKS 
               
               
                 AF094481 
                 1.37131E−05 
                 5.009E−06 
                 2.74E−07 
                 −0.29045 
                 CGGBP1 
               
               
                 AF098641 
                 2.63714E−07 
                 1.715E−07 
                 1.56E−07 
                 −0.41172 
               
               
                 AF110377 
                 1.37131E−05 
                 5.009E−06 
                 3.05E−05 
                 0.361232 
                 TRRAP 
               
               
                 AF117829 
                 7.44428E−05 
                 0.000129 
                 2.61E−06 
                 −0.57516 
                 RIPK2 
               
               
                 AI133727 
                 7.44428E−05 
                 0.0001187 
                 1.43E−06 
                 0.181464 
                 FLB6421 
               
               
                 AI141670 
                 0.000344298 
                 0.0003041 
                  1.6E−06 
                 −0.2494 
                 CLCN2 
               
               
                 AI148772 
                 0.000344298 
                  4.67E−05 
                 4.18E−06 
                 −1.02619 
                 KYNU 
               
               
                 AI184802 
                 2.63714E−07 
                 2.188E−08 
                 2.67E−09 
                 −0.21576 
                 HPRP4P 
               
               
                 AI560890 
                 2.57282E−08 
                 2.829E−08 
                  1.8E−07 
                 0.179028 
               
               
                 AI670100 
                 7.44428E−05 
                 2.577E−05 
                  7.7E−07 
                 0.22677 
                 GRLF1 
               
               
                 AI754391 
                 1.37131E−05 
                 3.861E−06 
                 1.72E−06 
                 −0.27657 
                 KLF12 
               
               
                 AI935146 
                 0.000344298 
                  2.35E−05 
                 2.05E−06 
                 −0.46726 
                 GALNT3 
               
               
                 AI950382 
                 1.37131E−05 
                 1.613E−06 
                 1.63E−07 
                 −0.74128 
                 KIAA0585 
               
               
                 AI970189 
                 0.000344298 
                  2.35E−05 
                 6.16E−07 
                 −0.75934 
                 KIAA0997 
               
               
                 AJ002190 
                 7.44428E−05 
                 1.613E−06 
                 2.17E−08 
                 0.33775 
                 GNPAT 
               
               
                 AJ007042 
                 2.63714E−07 
                 1.715E−07 
                  2.1E−07 
                 0.170935 
                 WHSC1 
               
               
                 AJ010059 
                 2.10971E−06 
                 5.045E−07 
                 2.95E−06 
                 0.2235 
                 SIT 
               
               
                 AL008583 
                 2.63714E−07 
                 2.188E−08 
                 1.12E−08 
                 0.250082 
                 CBX6 
               
               
                 AL021154 
                 0.000344298 
                  4.67E−05 
                 2.19E−06 
                 −0.82935 
                 ID3 
               
               
                 AL021707 
                 0.000344298 
                 7.048E−06 
                 4.95E−06 
                 −2.21462 
               
               
                 AL022398 
                 7.44428E−05 
                 1.613E−06 
                 8.09E−08 
                 0.919627 
               
               
                 AL022398 
                 7.44428E−05 
                 7.048E−06 
                  1.1E−07 
                 0.79713 
                 DJ434O14.3 
               
               
                 AL022398 
                 7.44428E−05 
                 2.577E−05 
                  2.4E−06 
                 0.493166 
               
               
                 AL023553 
                 1.37131E−05 
                 1.753E−05 
                 2.51E−06 
                 0.226635 
                 PMM1 
               
               
                 AL049387 
                 0.00137719 
                 0.0001897 
                 5.12E−06 
                 0.379296 
               
               
                 AL049409 
                 7.44428E−05 
                 1.511E−05 
                  1.1E−06 
                 0.714173 
                 LEF1 
               
               
                 AL049782 
                 7.44428E−05 
                 2.577E−05 
                 7.66E−07 
                 0.237794 
               
               
                 AL049787 
                 1.37131E−05 
                 5.009E−06 
                 7.11E−06 
                 0.311278 
               
               
                 AL049963 
                 0.000344298 
                  4.67E−05 
                 8.36E−07 
                 −0.74421 
                 LOC64116 
               
               
                 AL050084 
                 7.44428E−05 
                 1.613E−06 
                 5.26E−05 
                 0.509331 
                 DC8 
               
               
                 AL050087 
                 2.10971E−06 
                 2.484E−06 
                 1.27E−07 
                 −0.31279 
                 KIAA1785 
               
               
                 AL050196 
                 1.37131E−05 
                 5.009E−06 
                   2E−05 
                 −0.24688 
                 DKFZP586D2223 
               
               
                 AL050281 
                 0.000344298 
                 0.0002051 
                 2.85E−06 
                 0.30517 
                 NAG 
               
               
                 AL050353 
                 0.000344298 
                  2.35E−05 
                 4.42E−06 
                 0.179352 
                 OIP2 
               
               
                 AL050371 
                 0.000344298 
                  2.35E−05 
                  3.7E−06 
                 0.493288 
                 PISD 
               
               
                 AL080071 
                 0.000344298 
                 0.0003041 
                 3.12E−06 
                 0.237367 
                 DKFZP564M082 
               
               
                 AL080141 
                 1.37131E−05 
                 5.009E−06 
                 2.42E−07 
                 0.330868 
                 SEC31B-1 
               
               
                 AL096780 
                 1.37131E−05 
                 5.045E−07 
                 2.13E−06 
                 0.34487 
                 CHKL 
               
               
                 AW051579 
                 1.37131E−05 
                 1.613E−06 
                 7.58E−07 
                 0.593476 
                 FLJ10512 
               
               
                 D10704 
                 1.37131E−05 
                 1.753E−05 
                 4.69E−07 
                 −0.36791 
                 CHK 
               
               
                 D13891 
                 2.10971E−06 
                 2.484E−06 
                 4.57E−05 
                 −0.20577 
                 ID2 
               
               
                 D30758 
                 2.10971E−06 
                 1.993E−06 
                 1.58E−05 
                 0.27738 
                 CENTB1 
               
               
                 D30783 
                 2.57282E−08 
                 2.829E−08 
                 8.95E−10 
                 −1.65011 
                 EREG 
               
               
                 D49677 
                 7.44428E−05 
                 7.048E−06 
                 4.18E−06 
                 0.198707 
                 U2AF1RS2 
               
               
                 D50406 
                 1.37131E−05 
                 3.861E−06 
                 2.65E−05 
                 0.461907 
                 RECK 
               
               
                 D50525 
                 0.000344298 
                  4.67E−05 
                 3.02E−06 
                 0.486698 
               
               
                 D78579 
                 1.37131E−05 
                 7.048E−06 
                 4.25E−07 
                 −1.65638 
                 NR4A3 
               
               
                 D78579 
                 7.44428E−05 
                 7.048E−06 
                 9.62E−07 
                 −1.61438 
                 NR4A3 
               
               
                 D80011 
                 7.44428E−05 
                 1.613E−06 
                  4.2E−07 
                 −0.35073 
                 KIAA0189 
               
               
                 D87119 
                 7.44428E−05 
                  2.35E−05 
                  1.8E−06 
                 0.425625 
                 GS3955 
               
               
                 D87119 
                 7.44428E−05 
                 5.226E−05 
                 4.62E−06 
                 0.557116 
                 GS3955 
               
               
                 D87466 
                 1.37131E−05 
                 8.661E−06 
                 1.49E−07 
                 0.466046 
                 KIAA0276 
               
               
                 HG1103-HT1103 
                 1.37131E−05 
                 1.613E−06 
                 1.16E−07 
                 −0.39165 
               
               
                 HG2007-HT2056 
                 7.44428E−05 
                 9.644E−05 
                 4.01E−06 
                 −0.41408 
               
               
                 HG2724-HT2820 
                 1.37131E−05 
                  3.06E−05 
                 5.17E−06 
                 −1.33814 
               
               
                 HG3227-HT3404 
                 2.63714E−07 
                 1.715E−07 
                 1.68E−08 
                 −0.25361 
               
               
                 HG4582-HT4987 
                 7.44428E−05 
                  2.35E−05 
                 4.63E−07 
                 −0.39588 
               
               
                 J02939 
                 7.44428E−05 
                 1.613E−06 
                 2.16E−07 
                 −0.87844 
                 SLC3A2 
               
               
                 J02973 
                 1.37131E−05 
                 5.045E−07 
                 2.93E−07 
                 −1.30804 
                 THBD 
               
               
                 J03258 
                 0.000344298 
                 0.0001695 
                 1.21E−06 
                 −0.58295 
                 VDR 
               
               
                 J04130 
                 0.000344298 
                  2.35E−05 
                 3.02E−06 
                 −0.62071 
                 SCYA4 
               
               
                 L04733 
                 0.00137719 
                  2.35E−05 
                 8.84E−07 
                 0.306455 
                 KNS2 
               
               
                 L05424 
                 2.10971E−06 
                 1.329E−07 
                 2.27E−09 
                 −0.58081 
                 CD44 
               
               
                 L12002 
                 7.44428E−05 
                  4.67E−05 
                 1.23E−06 
                 0.286717 
                 ITGA4 
               
               
                 L13740 
                 2.63714E−07 
                 2.188E−08 
                 5.83E−08 
                 −1.45891 
                 NR4A1 
               
               
                 L13740 
                 1.37131E−05 
                 5.009E−06 
                  9.1E−08 
                 −0.61928 
                 NR4A1 
               
               
                 L13773 
                 1.37131E−05 
                 1.753E−05 
                 6.44E−07 
                 0.247919 
                 MLLT2 
               
               
                 L16499 
                 1.37131E−05 
                 8.661E−06 
                 5.12E−06 
                 0.374296 
                 HHEX 
               
               
                 L20941 
                 2.63714E−07 
                 1.329E−07 
                 1.78E−06 
                 −0.58618 
                 FTH1 
               
               
                 L22075 
                 2.63714E−07 
                 2.488E−07 
                  1.1E−08 
                 −0.55736 
                 GNA13 
               
               
                 L22569 
                 1.37131E−05 
                 8.661E−06 
                 1.52E−06 
                 0.318129 
                 CTSB 
               
               
                 L25665 
                 0.000344298 
                 0.0001695 
                 3.34E−06 
                 −0.4513 
                 GNL1 
               
               
                 L33881 
                 2.63714E−07 
                 1.715E−07 
                 5.06E−08 
                 −0.59585 
                 PRKCI 
               
               
                 L40377 
                 1.37131E−05 
                 5.045E−07 
                 3.49E−07 
                 −0.79409 
                 SERPINB8 
               
               
                 L47738 
                 2.57282E−08 
                 4.013E−09 
                 7.54E−09 
                 0.31646 
                 PIR121 
               
               
                 L78132 
                 7.44428E−05 
                 5.226E−05 
                 5.15E−07 
                 0.358576 
                 LGALS8 
               
               
                 M12267 
                 0.000344298 
                 0.0001695 
                 4.07E−06 
                 −0.3279 
                 OAT 
               
               
                 M12959 
                 7.44428E−05 
                 2.577E−05 
                 1.61E−06 
                 0.128482 
                 TRA@ 
               
               
                 M15330 
                 8.54758E−11 
                 8.548E−11 
                 2.49E−12 
                 −2.13825 
                 IL1B 
               
               
                 M17017 
                 7.44428E−05 
                 0.0001187 
                 1.43E−06 
                 −1.74073 
                 IL8 
               
               
                 M22919 
                 2.63714E−07 
                 3.119E−07 
                 9.52E−08 
                 −0.81053 
                 MYL6 
               
               
                 M23114 
                 2.10971E−06 
                 4.309E−06 
                 1.59E−07 
                 −0.96141 
                 ATP2A2 
               
               
                 M24194 
                 7.44428E−05 
                 1.613E−06 
                 4.38E−06 
                 0.560895 
                 GNB2L1 
               
               
                 M24283 
                 0.000344298 
                  4.67E−05 
                 3.71E−06 
                 −1.32611 
                 ICAM1 
               
               
                 M24895 
                 2.10971E−06 
                 1.329E−07 
                 1.72E−08 
                 0.476779 
                 AMY2B 
               
               
                 M26683 
                 7.44428E−05 
                 0.0001187 
                  3.7E−06 
                 −0.16179 
                 SCYA2 
               
               
                 M27492 
                 0.000344298 
                 0.0004017 
                 2.01E−06 
                 −0.32619 
                 IL1R1 
               
               
                 M28130 
                 7.44428E−05 
                  4.67E−05 
                 8.02E−07 
                 −2.27292 
                 IL8 
               
               
                 M31165 
                 7.44428E−05 
                 5.226E−05 
                 1.38E−06 
                 −0.34617 
                 TNFAIP6 
               
               
                 M31523 
                 1.37131E−05 
                 1.753E−05 
                 2.09E−06 
                 0.36898 
                 TCF3 
               
               
                 M36821 
                 1.37131E−05 
                 8.661E−06 
                 2.21E−07 
                 −0.36334 
                 GRO3 
               
               
                 M55153 
                 7.44428E−05 
                 2.577E−05 
                 4.77E−06 
                 −0.27465 
                 TGM2 
               
               
                 M58603 
                 7.44428E−05 
                 5.226E−05 
                 1.28E−06 
                 −0.73537 
                 NFKB1 
               
               
                 M59040 
                 0.00137719 
                  2.35E−05 
                 2.82E−06 
                 −0.46271 
                 CD44 
               
               
                 M60784 
                 7.44428E−05 
                 5.226E−05 
                 1.24E−06 
                 0.559903 
                 SNRPA 
               
               
                 M60922 
                 7.44428E−05 
                 1.511E−05 
                 4.47E−08 
                 0.39657 
                 FLOT2 
               
               
                 M62403 
                 7.44428E−05 
                 5.226E−05 
                 5.57E−07 
                 −0.53749 
                 IGFBP4 
               
               
                 M63256 
                 0.000344298 
                 5.915E−05 
                 6.54E−07 
                 0.454561 
                 CDR2 
               
               
                 M63904 
                 2.57282E−08 
                 1.031E−08 
                 5.38E−09 
                 −0.59612 
                 GNA15 
               
               
                 M63978 
                 0.000344298 
                  4.67E−05 
                 1.77E−06 
                 −0.44762 
                 VEGF 
               
               
                 M64571 
                 1.83773E−09 
                 1.838E−09 
                 2.41E−11 
                 0.416659 
                 MAP4 
               
               
                 M69199 
                 2.10971E−06 
                 1.993E−06 
                 1.45E−07 
                 −1.9021 
                 G0S2 
               
               
                 M73547 
                 1.37131E−05 
                 5.009E−06 
                  9.2E−08 
                 0.438897 
                 D5S346 
               
               
                 M74525 
                 2.10971E−06 
                 2.484E−06 
                  3.5E−07 
                 −0.61792 
                 UBE2B 
               
               
                 M80244 
                 0.000344298 
                 7.048E−06 
                 2.72E−06 
                 −0.8522 
                 SLC7A5 
               
               
                 M84443 
                 1.37131E−05 
                 5.045E−07 
                 4.08E−07 
                 0.303567 
                 GALK2 
               
               
                 M94856 
                 7.44428E−05 
                 5.226E−05 
                 4.99E−06 
                 −0.23847 
                 FABP5 
               
               
                 M95678 
                 0.000344298 
                 7.048E−06 
                   2E−06 
                 0.432923 
                 PLCB2 
               
               
                 M98833 
                 7.44428E−05 
                 1.613E−06 
                 1.52E−06 
                 0.434288 
                 FLI1 
               
               
                 N23137 
                 2.10971E−06 
                 2.484E−06 
                 2.06E−07 
                 0.247311 
                 MPHOSPH9 
               
               
                 N23137 
                 0.00137719 
                 0.0001695 
                 4.12E−06 
                 0.244083 
                 MPHOSPH9 
               
               
                 N30151 
                 7.44428E−05 
                 1.613E−06 
                 5.05E−05 
                 0.393521 
                 STX16 
               
               
                 N42007 
                 2.10971E−06 
                 2.484E−06 
                 9.19E−05 
                 0.167986 
                 NUP50 
               
               
                 N53547 
                 7.44428E−05 
                 8.556E−05 
                  1.8E−07 
                 0.296678 
                 MGC5508 
               
               
                 N90862 
                 1.37131E−05 
                 5.045E−07 
                 3.28E−08 
                 0.43576 
                 VAMP8 
               
               
                 N90866 
                 2.63714E−07 
                 8.227E−08 
                 2.76E−08 
                 0.304525 
                 CDW52 
               
               
                 N98667 
                 1.37131E−05 
                 8.661E−06 
                 3.38E−07 
                 0.367127 
                 KIAA1696 
               
               
                 R90942 
                 1.37131E−05 
                 5.009E−06 
                 1.05E−05 
                 −0.17696 
                 ST6GALNACIV 
               
               
                 S52028 
                 2.10971E−06 
                 5.045E−07 
                 9.62E−08 
                 −0.81662 
                 CTH 
               
               
                 S68134 
                 0.000344298 
                 7.048E−06 
                 8.37E−07 
                 −1.64652 
                 CREM 
               
               
                 S68134 
                 0.000344298 
                 7.048E−06 
                 4.35E−06 
                 −2.47105 
                 CREM 
               
               
                 S68271 
                 0.000344298 
                 7.048E−06 
                 3.03E−06 
                 −2.07185 
                 CREM 
               
               
                 S73591 
                 1.37131E−05 
                 1.511E−05 
                 4.68E−06 
                 0.414777 
                 VDUP1 
               
               
                 S76638 
                 7.44428E−05 
                  2.35E−05 
                 7.47E−07 
                 −0.35416 
                 NFKB2 
               
               
                 S78187 
                 7.44428E−05 
                 1.613E−06 
                 1.95E−05 
                 0.203265 
                 CDC25B 
               
               
                 S78771 
                 0.000344298 
                 5.915E−05 
                 2.55E−06 
                 −0.31389 
                 BRD2 
               
               
                 S81914 
                 0.000344298 
                 7.048E−06 
                 4.18E−07 
                 −1.59146 
                 IER3 
               
               
                 U02020 
                 1.37131E−05 
                 8.661E−06 
                 1.37E−06 
                 −1.13863 
                 PBEF 
               
               
                 U02570 
                 1.37131E−05 
                 2.813E−05 
                 1.26E−06 
                 0.432431 
                 ARHGAP1 
               
               
                 U03634 
                 1.37131E−05 
                 1.753E−05 
                   1E−06 
                 −0.21467 
                 LBC 
               
               
                 U04636 
                 0.000344298 
                 5.915E−05 
                 2.81E−06 
                 −1.85123 
                 PTGS2 
               
               
                 U05681 
                 7.44428E−05 
                 5.226E−05 
                 3.37E−06 
                 −0.35383 
                 BCL3 
               
               
                 U07563 
                 7.44428E−05 
                  2.35E−05 
                 4.91E−07 
                 −0.25016 
                 ABL1 
               
               
                 U09937 
                 1.83773E−09 
                 4.157E−10 
                 2.04E−09 
                 −1.21578 
                 PLAUR 
               
               
                 U10117 
                 7.44428E−05 
                 1.511E−05 
                 4.07E−06 
                 0.563673 
                 SCYE1 
               
               
                 U11732 
                 1.37131E−05 
                 3.861E−06 
                 3.04E−07 
                 −0.22574 
                 ETV6 
               
               
                 U12767 
                 7.44428E−05 
                 1.613E−06 
                 2.84E−07 
                 −1.23483 
                 NR4A3 
               
               
                 U12767 
                 0.000344298 
                 7.048E−06 
                 2.55E−07 
                 −2.13744 
                 NR4A3 
               
               
                 U13695 
                 7.44428E−05 
                 1.613E−06 
                 1.11E−05 
                 0.805607 
                 PMS1 
               
               
                 U15552 
                 1.37131E−05 
                 5.009E−06 
                 1.67E−05 
                 −0.68094 
                 HSU15552 
               
               
                 U17760 
                 0.000344298 
                 7.048E−06 
                 4.25E−06 
                 −0.84472 
                 LAMB3 
               
               
                 U18300 
                 7.44428E−05 
                 0.000129 
                 2.43E−06 
                 0.183171 
                 DDB2 
               
               
                 U20982 
                 2.10971E−06 
                 1.993E−06 
                  1.2E−08 
                 −0.67125 
                 IGFBP4 
               
               
                 U24166 
                 7.44428E−05 
                 1.613E−06 
                 7.52E−06 
                 −0.45293 
                 MAPRE1 
               
               
                 U28811 
                 0.000344298 
                 7.048E−06 
                 1.33E−06 
                 0.32855 
                 GLG1 
               
               
                 U29171 
                 1.37131E−05 
                 5.009E−06 
                  1.1E−06 
                 −0.6032 
                 CSNK1D 
               
               
                 U29175 
                 1.37131E−05 
                 8.661E−06 
                  1.9E−06 
                 0.266342 
                 SMARCA4 
               
               
                 U29185 
                 2.10971E−06 
                 7.732E−07 
                 1.56E−07 
                 −1.08006 
                 PRNP 
               
               
                 U29344 
                 2.10971E−06 
                 9.536E−07 
                 2.35E−07 
                 −0.43842 
                 FASN 
               
               
                 U29656 
                 2.10971E−06 
                 7.732E−07 
                 7.52E−08 
                 0.353186 
                 NME3 
               
               
                 U29656 
                 7.44428E−05 
                 0.000129 
                 4.31E−06 
                 0.471876 
                 NME3 
               
               
                 U32324 
                 1.37131E−05 
                 5.045E−07 
                 3.21E−08 
                 0.334966 
                 IL11RA 
               
               
                 U33017 
                 2.63714E−07 
                 1.715E−07 
                  5.2E−07 
                 0.373581 
                 SLAM 
               
               
                 U38847 
                 7.44428E−05 
                  2.35E−05 
                 9.91E−07 
                 0.222946 
                 TARBP1 
               
               
                 U41815 
                 1.37131E−05 
                 5.045E−07 
                 2.16E−07 
                 −0.96931 
                 NUP98 
               
               
                 U43774 
                 0.000344298 
                  2.35E−05 
                  8.8E−07 
                 −0.39938 
                 FCAR 
               
               
                 U44839 
                 2.10971E−06 
                 9.536E−07 
                 2.54E−07 
                 −0.97008 
                 USP11 
               
               
                 U47414 
                 2.10971E−06 
                 9.536E−07 
                 2.31E−06 
                 0.370736 
                 CCNG2 
               
               
                 U47927 
                 2.57282E−08 
                 2.829E−08 
                 5.53E−09 
                 0.545592 
                 USP5 
               
               
                 U48807 
                 1.37131E−05 
                 5.009E−06 
                 4.97E−08 
                 −0.93178 
                 DUSP4 
               
               
                 U49187 
                 7.44428E−05 
                 1.511E−05 
                 1.48E−06 
                 0.671467 
                 C6orf32 
               
               
                 U49187 
                 7.44428E−05 
                 9.644E−05 
                 3.53E−06 
                 0.511392 
                 C6orf32 
               
               
                 U49844 
                 7.44428E−05 
                 7.048E−06 
                 3.67E−07 
                 0.47168 
                 ATR 
               
               
                 U50527 
                 1.37131E−05 
                 5.009E−06 
                 5.11E−06 
                 0.416543 
               
               
                 U50928 
                 7.44428E−05 
                 1.613E−06 
                 4.72E−06 
                 0.302213 
                 PKD2 
               
               
                 U51007 
                 7.44428E−05 
                 1.511E−05 
                 1.49E−06 
                 0.309996 
                 PSMD4 
               
               
                 U51205 
                 1.37131E−05 
                 5.045E−07 
                 2.65E−07 
                 −0.76279 
                 COP9 
               
               
                 U51478 
                 7.44428E−05 
                  2.35E−05 
                  6.1E−07 
                 −0.58 
                 ATP1B3 
               
               
                 U51920 
                 2.10971E−06 
                 1.329E−07 
                 7.01E−08 
                 −0.28142 
                 SRP54 
               
               
                 U52960 
                 2.10971E−06 
                 1.613E−06 
                 1.51E−07 
                 −0.84863 
                 SURB7 
               
               
                 U56998 
                 0.000344298 
                 7.048E−06 
                  3.7E−06 
                 −0.74294 
                 CNK 
               
               
                 U64197 
                 1.83773E−09 
                 1.838E−09 
                 2.95E−10 
                 −0.62373 
                 SCYA20 
               
               
                 U65928 
                 7.44428E−05 
                  4.67E−05 
                 2.85E−07 
                 0.408918 
                 COPS5 
               
               
                 U66063 
                 2.10971E−06 
                 2.484E−06 
                  4.7E−07 
                 0.277185 
                 CAMK2G 
               
               
                 U70735 
                 1.37131E−05 
                 8.661E−06 
                 1.82E−06 
                 0.249185 
                 MOV34-34KD 
               
               
                 U72066 
                 2.57282E−08 
                 1.031E−08 
                 4.33E−08 
                 −0.34482 
                 RBBP8 
               
               
                 U75968 
                 2.10971E−06 
                 1.993E−06 
                 4.36E−06 
                 0.139542 
                 DDX11 
               
               
                 U78107 
                 8.54758E−11 
                 3.691E−11 
                 4.04E−12 
                 −0.43769 
                 NAPG 
               
               
                 U78302 
                 2.63714E−07 
                 1.715E−07 
                 2.41E−08 
                 0.329878 
                 DECR1 
               
               
                 U78798 
                 2.57282E−08 
                 4.013E−09 
                 1.11E−06 
                 −0.3172 
                 TRAF6 
               
               
                 U84007 
                 7.44428E−05 
                 1.613E−06 
                 0.000235 
                 0.236422 
                 AGL 
               
               
                 U85245 
                 7.44428E−05 
                 1.613E−06 
                 4.57E−07 
                 0.365266 
                 PIP5K2B 
               
               
                 U88629 
                 0.000344298 
                  4.67E−05 
                 9.58E−07 
                 −0.32607 
                 ELL2 
               
               
                 U90917 
                 1.37131E−05 
                 1.613E−06 
                 3.89E−07 
                 0.433406 
                 FOXM1 
               
               
                 U91543 
                 2.63714E−07 
                 3.119E−07 
                 2.01E−07 
                 0.478678 
                 CHD3 
               
               
                 U91616 
                 1.37131E−05 
                 5.045E−07 
                 1.27E−07 
                 −0.80419 
                 NFKBIE 
               
               
                 U96876 
                 7.44428E−05 
                 1.613E−06 
                 3.54E−06 
                 −0.45317 
                 INSIG1 
               
               
                 U97105 
                 1.37131E−05 
                 1.753E−05 
                 6.56E−07 
                 1.00615 
                 DPYSL2 
               
               
                 W28319 
                 1.37131E−05 
                 5.009E−06 
                  1.5E−05 
                 0.294631 
                 FBLN1 
               
               
                 W28612 
                 1.37131E−05 
                 5.009E−06 
                  1.7E−06 
                 −0.25519 
               
               
                 W28743 
                 0.000344298 
                 7.048E−06 
                 2.78E−06 
                 −0.28926 
                 PP1628 
               
               
                 X00737 
                 2.10971E−06 
                 9.536E−07 
                 5.21E−08 
                 −0.67074 
                 NP 
               
               
                 X02152 
                 1.37131E−05 
                 5.045E−07 
                 4.63E−08 
                 −0.75601 
                 LDHA 
               
               
                 X04366 
                 1.37131E−05 
                 2.813E−05 
                 5.11E−06 
                 0.346076 
                 CAPN1 
               
               
                 X04500 
                 2.63714E−07 
                 1.715E−07 
                 3.43E−10 
                 −2.12121 
                 IL1B 
               
               
                 X06256 
                 1.37131E−05 
                  2.35E−05 
                 4.89E−07 
                 −0.7357 
                 ITGA5 
               
               
                 X13403 
                 7.44428E−05 
                 5.915E−05 
                 4.21E−07 
                 0.146032 
                 POU2F1 
               
               
                 X15217 
                 7.44428E−05 
                  4.67E−05 
                 3.77E−07 
                 −0.2371 
                 SKIL 
               
               
                 X15218 
                 8.54758E−11 
                 8.548E−11 
                  1.4E−10 
                 −1.41501 
                 SKI 
               
               
                 X16396 
                 0.000344298 
                 0.0002051 
                 3.27E−06 
                 −0.6151 
                 MTHFD2 
               
               
                 X16706 
                 7.44428E−05 
                 1.613E−06 
                 1.23E−06 
                 −1.09747 
                 FOSL2 
               
               
                 X53586 
                 1.37131E−05 
                 8.661E−06 
                  3.4E−07 
                 0.51291 
                 ITGA6 
               
               
                 X58141 
                 7.44428E−05 
                 9.644E−05 
                 1.75E−06 
                 0.384254 
                 ADD1 
               
               
                 X61123 
                 7.44428E−05 
                 0.0001057 
                 4.17E−07 
                 −1.15256 
                 BTG1 
               
               
                 X61498 
                 7.44428E−05 
                 1.613E−06 
                  8.8E−07 
                 −0.49884 
                 NFKB2 
               
               
                 X62535 
                 1.37131E−05 
                 1.613E−06 
                 5.68E−07 
                 0.243937 
                 DGKA 
               
               
                 X63368 
                 2.10971E−06 
                 5.045E−07 
                  2.3E−08 
                 −0.55432 
                 DNAJB2 
               
               
                 X64330 
                 7.44428E−05 
                 7.048E−06 
                 2.27E−06 
                 0.297851 
                 ACLY 
               
               
                 X66363 
                 2.63714E−07 
                 1.715E−07 
                 6.53E−07 
                 −0.24505 
                 PCTK1 
               
               
                 X66436 
                 0.000344298 
                 8.556E−05 
                 1.88E−06 
                 −0.26662 
               
               
                 X66945 
                 7.44428E−05 
                 1.511E−05 
                 1.91E−07 
                 −0.35494 
                 FGFR1 
               
               
                 X68452 
                 2.57282E−08 
                 4.013E−09 
                 9.12E−11 
                 −0.26618 
                 CCND2 
               
               
                 X69392 
                 2.63714E−07 
                 1.329E−07 
                  1.1E−08 
                 0.297444 
                 RPL26 
               
               
                 X70218 
                 1.37131E−05 
                  3.06E−05 
                 2.44E−06 
                 −0.74691 
                 PPP4C 
               
               
                 X74039 
                 1.83773E−09 
                 4.157E−10 
                 1.51E−10 
                 −0.67381 
                 PLAUR 
               
               
                 X79882 
                 1.37131E−05 
                 5.045E−07 
                 1.78E−07 
                 0.520965 
                 MVP 
               
               
                 X82153 
                 7.44428E−05 
                 1.613E−06 
                 2.27E−06 
                 0.47844 
                 CTSK 
               
               
                 X82209 
                 2.10971E−06 
                 5.045E−07 
                 1.37E−09 
                 −0.45281 
                 MN1 
               
               
                 X87949 
                 7.44428E−05 
                 1.613E−06 
                 4.05E−07 
                 −0.54468 
                 HSPA5 
               
               
                 X98172 
                 7.44428E−05 
                  4.67E−05 
                 5.29E−07 
                 0.507556 
                 CASP8 
               
               
                 X99142 
                 1.37131E−05 
                 8.661E−06 
                 1.24E−06 
                 −0.29773 
                 KRTHB6 
               
               
                 X99656 
                 1.37131E−05 
                 5.045E−07 
                 1.68E−06 
                 −0.23553 
                 SH3GL1 
               
               
                 Y00630 
                 2.57282E−08 
                 3.695E−08 
                 6.65E−09 
                 −2.38485 
                 SERPINB2 
               
               
                 Y08683 
                 1.37131E−05 
                 5.045E−07 
                 4.71E−06 
                 0.492738 
                 CPT1B 
               
               
                 Y14768 
                 1.37131E−05 
                 5.045E−07 
                 7.26E−08 
                 0.248383 
                 LTB 
               
               
                 Y18004 
                 1.37131E−05 
                 5.009E−06 
                 4.19E−07 
                 −0.9465 
                 SCML2 
               
               
                 Z11697 
                 1.37131E−05 
                 5.045E−07 
                 3.55E−06 
                 −1.21033 
                 CD83 
               
               
                 Z14000 
                 0.000344298 
                 0.0002051 
                 3.91E−06 
                 −0.33734 
                 RING1 
               
               
                 Z24724 
                 2.63714E−07 
                 2.188E−08 
                 5.96E−09 
                 −1.10426 
               
               
                 Z32860 
                 1.37131E−05 
                 5.009E−06 
                 7.81E−06 
                 0.133192 
               
               
                 Z93930 
                 2.63714E−07 
                 2.488E−07 
                 2.42E−05 
                 −0.39839 
                 XBP1 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE III 
               
             
            
               
                   
               
               
                   
               
               
                 Differential Gene Expression in acute MS relapse vs. remission 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 TNOM 
                 Info 
                 t-Test 
                 Log Fold 
                   
               
               
                 Identifier 
                 PValue 
                 PValue 
                 PValue 
                 Change 
                 Symbol 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 AI828210 
                 5.38E−06 
                 5.38E−06 
                 8.37E−06 
                 −0.18947 
                 KIAA0284 
               
               
                 D14710 
                 6.73E−05 
                 3.19E−05 
                 2.89E−05 
                 −0.35496 
                 ATP5A1 
               
               
                 U46692 
                 6.73E−05 
                 3.19E−05 
                 0.000284 
                 −0.49741 
                 CSTB 
               
               
                 AF061261 
                 6.73E−05 
                 3.19E−05 
                 3.22E−05 
                 −0.28274 
                 MBLL 
               
               
                 U51712 
                 6.73E−05 
                 3.19E−05 
                 0.003464 
                 −0.42775 
                 SMAP31 
               
               
                 AB014558 
                 6.73E−05 
                 4.25E−05 
                 0.000473 
                 0.694784 
                 CRY2 
               
               
                 AB007936 
                 6.73E−05 
                 4.25E−05 
                 0.000958 
                 −0.25409 
                 KIAA0467 
               
               
                 AC002115 
                 6.73E−05 
                 4.25E−05 
                 0.000147 
                 0.622841 
                 MGC10433 
               
               
                 AF052160 
                 6.73E−05 
                 4.25E−05 
                 0.000182 
                 −0.46468 
               
               
                 S78085 
                 0.000538 
                 0.000104 
                 0.000102 
                 −0.55064 
                 PDCD2 
               
               
                 AL096719 
                 0.000538 
                 0.000104 
                 0.000089 
                 −0.22287 
                 PFN2 
               
               
                 U61234 
                 0.000538 
                 0.000104 
                 0.000844 
                 0.299182 
                 TBCC 
               
               
                 X12451 
                 0.000538 
                 0.000251 
                 0.000876 
                 1.04444 
                 CTSL 
               
               
                 M35531 
                 0.000538 
                 0.000251 
                 0.000241 
                 −0.20303 
                 FUT1 
               
               
                 M64174 
                 0.000538 
                 0.000251 
                 3.43E−05 
                 −0.5508 
                 JAK1 
               
               
                 AB018269 
                 0.000538 
                 0.000251 
                 7.39E−05 
                 −0.18186 
                 KIAA0726 
               
               
                 R92331 
                 0.000538 
                 0.000251 
                 0.000104 
                 0.289994 
                 MT1E 
               
               
                 U19487 
                 0.000538 
                 0.000251 
                 0.001738 
                 −0.25888 
                 PTGER2 
               
               
                 AF040965 
                 0.000538 
                 0.000251 
                 0.000775 
                 0.48898 
                 RES4-25 
               
               
                 U07563 
                 0.000538 
                 0.000251 
                 3.61E−05 
                 −0.16779 
                 RRP4 
               
               
                 L40377 
                 0.000538 
                 0.000251 
                 0.009479 
                 0.452416 
                 SERPINB8 
               
               
                 AL080234 
                 0.000538 
                 0.000251 
                 0.000377 
                 −0.52631 
               
               
                 AJ242015 
                 0.003096 
                 0.00039 
                 0.013957 
                 0.281618 
                 ADAM28 
               
               
                 D86324 
                 0.003096 
                 0.00039 
                 0.001801 
                 −0.34728 
                 CMAH 
               
               
                 M94065 
                 0.003096 
                 0.00039 
                 0.002391 
                 −0.13976 
                 DHODH 
               
               
                 AC004382 
                 0.003096 
                 0.00039 
                 0.000121 
                 −0.20383 
                 DKFZP434K046 
               
               
                 X54326 
                 0.003096 
                 0.00039 
                 0.002734 
                 −0.39559 
                 EPRS 
               
               
                 W25921 
                 0.003096 
                 0.00039 
                 9.41E−05 
                 −0.39027 
                 GNS 
               
               
                 X92110 
                 0.003096 
                 0.00039 
                 0.000103 
                 −1.00581 
                 HCGVIII-1 
               
               
                 W28589 
                 0.003096 
                 0.00039 
                 0.000225 
                 −0.20949 
                 HSPD1 
               
               
                 S66213 
                 0.003096 
                 0.00039 
                 0.000134 
                 −0.28606 
                 ITGA6 
               
               
                 AB011158 
                 0.000538 
                 0.00039 
                 0.000047 
                 −0.163 
                 KIAA0586 
               
               
                 AB023209 
                 0.003096 
                 0.00039 
                 0.003354 
                 −0.09151 
                 KIAA0992 
               
               
                 AF035940 
                 0.003096 
                 0.00039 
                 0.008457 
                 0.282437 
                 MAGOH 
               
               
                 M31724 
                 0.003096 
                 0.00039 
                 0.000671 
                 0.569343 
                 PTPN1 
               
               
                 X74262 
                 0.003096 
                 0.00039 
                 0.000062 
                 −0.37623 
                 RBBP4 
               
               
                 J05249 
                 0.003096 
                 0.00039 
                 0.00045 
                 −0.52346 
                 RPA2 
               
               
                 M55531 
                 0.003096 
                 0.00039 
                 0.023054 
                 −0.22329 
                 SLC2A5 
               
               
                 AI865431 
                 0.003096 
                 0.00039 
                 0.00027 
                 0.423067 
                 TNFRSF5 
               
               
                 W28203 
                 0.003096 
                 0.00039 
                 0.007983 
                 −0.17484 
               
               
                 W28667 
                 0.003096 
                 0.00039 
                 0.000846 
                 −0.49488 
               
               
                 D13628 
                 0.000538 
                 0.000529 
                 0.034335 
                 −0.10398 
                 ANGPT1 
               
               
                 U03271 
                 0.000538 
                 0.000529 
                 0.000286 
                 −0.1675 
                 CAPZB 
               
               
                 U05259 
                 0.000538 
                 0.000529 
                 0.003589 
                 0.551328 
                 CD79A 
               
               
                 L13278 
                 0.000538 
                 0.000529 
                 7.27E−05 
                 −0.43636 
                 CRYZ 
               
               
                 M91670 
                 0.000538 
                 0.000529 
                 0.003472 
                 0.600255 
                 E2-EPF 
               
               
                 AB029030 
                 0.000538 
                 0.000529 
                 0.000657 
                 −0.13458 
                 KIAA1107 
               
               
                 AF016098 
                 0.000538 
                 0.000529 
                 0.000433 
                 −0.16189 
                 NRP2 
               
               
                 X76091 
                 0.000538 
                 0.000529 
                 0.004691 
                 0.161349 
                 RFX2 
               
               
                 U52191 
                 0.000538 
                 0.000529 
                 0.00229 
                 1.2356 
                 SMCY 
               
               
                 AA203345 
                 0.000538 
                 0.000529 
                 0.001228 
                 −0.50409 
                 STX16 
               
               
                 U96113 
                 0.000538 
                 0.000529 
                 0.000394 
                 −0.41425 
                 WWP1 
               
               
                 AL050263 
                 0.000538 
                 0.000529 
                 0.000224 
                 −0.15981 
               
               
                 Z48579 
                 0.000538 
                 0.000799 
                 0.000184 
                 −0.30836 
                 ADAM10 
               
               
                 M31452 
                 0.000538 
                 0.000799 
                 0.002899 
                 −0.13022 
                 C4BPA 
               
               
                 AC003107 
                 0.000538 
                 0.000799 
                 0.000262 
                 −0.16818 
                 COMP 
               
               
                 M91670 
                 0.000538 
                 0.000799 
                 0.000792 
                 0.41925 
                 E2-EPF 
               
               
                 AB023235 
                 0.000538 
                 0.000799 
                 0.001348 
                 −0.30138 
                 KIAA1018 
               
               
                 X89960 
                 0.000538 
                 0.000799 
                 0.026837 
                 −0.35169 
                 MCSP 
               
               
                 D55654 
                 0.000538 
                 0.000799 
                 0.019331 
                 −0.2254 
                 MDH1 
               
               
                 U02683 
                 0.000538 
                 0.000799 
                 0.030035 
                 −0.09324 
                 NRF1 
               
               
                 S90469 
                 0.000538 
                 0.000799 
                 0.000785 
                 0.23032 
                 POR 
               
               
                 AF020543 
                 0.000538 
                 0.000799 
                 0.004286 
                 −0.25061 
                 PPT2 
               
               
                 M34181 
                 0.000538 
                 0.000799 
                 0.000055 
                 −0.5883 
                 PRKACB 
               
               
                 AF095448 
                 0.000538 
                 0.000799 
                 0.000588 
                 −0.24961 
                 RAI3 
               
               
                 AF027150 
                 0.000538 
                 0.000799 
                 0.000979 
                 −0.16012 
                 SIP1 
               
               
                 X02344 
                 0.000538 
                 0.000799 
                 0.000918 
                 0.430531 
                 TUBB2 
               
               
                 X02344 
                 0.000538 
                 0.000799 
                 0.002225 
                 0.296682 
                 TUBB2 
               
               
                 AI701164 
                 0.000538 
                 0.000799 
                 0.000115 
                 −0.23639 
                 UBE2G1 
               
               
                 U96113 
                 0.000538 
                 0.000799 
                 9.77E−05 
                 −0.45711 
                 WWP1 
               
               
                 AF016052 
                 0.000538 
                 0.000799 
                 0.001254 
                 −0.19092 
                 ZNF24 
               
               
                 U21551 
                 0.003096 
                 0.00103 
                 0.000836 
                 0.278219 
                 BCAT1 
               
               
                 X77794 
                 0.003096 
                 0.00103 
                 3.72E−05 
                 −0.81938 
                 CCNG1 
               
               
                 AF070530 
                 0.003096 
                 0.00103 
                 0.014908 
                 0.276942 
                 CL24751 
               
               
                 AB002331 
                 0.003096 
                 0.00103 
                 0.001714 
                 −0.17304 
                 DATF1 
               
               
                 AI004207 
                 0.003096 
                 0.00103 
                 0.000762 
                 −0.1648 
                 FLJ00002 
               
               
                 L76200 
                 0.003096 
                 0.00103 
                 0.000824 
                 0.444479 
                 GUK1 
               
               
                 U26398 
                 0.003096 
                 0.00103 
                 0.001182 
                 −0.29185 
                 INPP4A 
               
               
                 U69883 
                 0.003096 
                 0.00103 
                 0.007922 
                 0.103614 
                 KCNN1 
               
               
                 M13452 
                 0.003096 
                 0.00103 
                 0.000467 
                 0.405856 
                 LMNA 
               
               
                 AA126505 
                 0.003096 
                 0.00103 
                 0.002 
                 −0.39781 
                 NCAM1 
               
               
                 U88620 
                 0.003096 
                 0.00103 
                 0.007562 
                 −0.3532 
                 OGG1 
               
               
                 M33336 
                 0.003096 
                 0.00103 
                 0.001568 
                 −0.26454 
                 PRKAR1A 
               
               
                 AB015982 
                 0.003096 
                 0.00103 
                 0.000382 
                 −0.27486 
                 PRKCN 
               
               
                 H68340 
                 0.003096 
                 0.00103 
                 0.001222 
                 0.516352 
                 RNAHP 
               
               
                 M28225 
                 0.003096 
                 0.00103 
                 0.000686 
                 1.0733 
                 SCYA2 
               
               
                 X97064 
                 0.003096 
                 0.00103 
                 0.003207 
                 −0.19906 
                 SEC23A 
               
               
                 X68560 
                 0.003096 
                 0.00103 
                 0.007856 
                 0.437567 
                 SP3 
               
               
                 AF064094 
                 0.003096 
                 0.00103 
                 0.000287 
                 −0.19385 
                 TADA2L 
               
               
                 AB007872 
                 0.003096 
                 0.00103 
                 0.000119 
                 −0.20778 
                 ZNF264 
               
               
                 W28255 
                 0.013622 
                 0.001698 
                 0.001407 
                 −0.24426 
                 76P 
               
               
                 AB007934 
                 0.003096 
                 0.001698 
                 0.003182 
                 −0.24405 
                 ACF7 
               
               
                 AL049954 
                 0.013622 
                 0.001698 
                 0.024193 
                 −0.25818 
                 AHCYL1 
               
               
                 U90546 
                 0.003096 
                 0.001698 
                 0.000105 
                 −0.34074 
                 BTN3A2 
               
               
                 AL035291 
                 0.013622 
                 0.001698 
                 0.007668 
                 0.506107 
                 CH1 
               
               
                 AF031647 
                 0.013622 
                 0.001698 
                 0.004755 
                 0.257244 
                 COPS3 
               
               
                 M57888 
                 0.003096 
                 0.001698 
                 0.004549 
                 −0.64384 
                 CTLA1 
               
               
                 AF000987 
                 0.003096 
                 0.001698 
                 0.009455 
                 0.247586 
                 EIF1AY 
               
               
                 U55766 
                 0.003096 
                 0.001698 
                 0.00066 
                 0.795017 
                 HRB2 
               
               
                 L12002 
                 0.013622 
                 0.001698 
                 0.005765 
                 −0.1942 
                 ITGA4 
               
               
                 D14661 
                 0.013622 
                 0.001698 
                 0.011324 
                 0.391267 
                 KIAA0105 
               
               
                 D63875 
                 0.013622 
                 0.001698 
                 0.002192 
                 −0.36411 
                 KIAA0155 
               
               
                 AB018285 
                 0.013622 
                 0.001698 
                 0.001545 
                 0.550994 
                 KIAA0742 
               
               
                 AB023180 
                 0.013622 
                 0.001698 
                 0.001642 
                 0.253479 
                 KIAA0963 
               
               
                 AL080102 
                 0.013622 
                 0.001698 
                 0.003651 
                 0.435751 
                 KIAA1856 
               
               
                 M22637 
                 0.013622 
                 0.001698 
                 0.003792 
                 −0.27794 
                 LYL1 
               
               
                 D85131 
                 0.013622 
                 0.001698 
                 0.005126 
                 −0.12291 
                 MAZ 
               
               
                 D37965 
                 0.013622 
                 0.001698 
                 0.01111 
                 −0.09143 
                 PDGFRL 
               
               
                 Y18207 
                 0.003096 
                 0.001698 
                 0.003474 
                 −0.17238 
                 PPP1R3C 
               
               
                 L49229 
                 0.013622 
                 0.001698 
                 0.000336 
                 −0.36639 
                 RB1 
               
               
                 U77664 
                 0.013622 
                 0.001698 
                 0.002354 
                 0.193666 
                 RPP38 
               
               
                 AL040137 
                 0.003096 
                 0.001698 
                 0.008384 
                 −0.23366 
                 SAP18 
               
               
                 D31764 
                 0.013622 
                 0.001698 
                 0.01295 
                 −0.13299 
                 SNX17 
               
               
                 X57655 
                 0.013622 
                 0.001698 
                 0.002476 
                 −0.17382 
                 SPINK2 
               
               
                 M19267 
                 0.013622 
                 0.001698 
                 0.013582 
                 0.262886 
                 TPM1 
               
               
                 M12959 
                 0.013622 
                 0.001698 
                 0.003907 
                 −0.08942 
                 TRA@ 
               
               
                 AA160724 
                 0.013622 
                 0.001698 
                 0.005695 
                 0.267002 
               
               
                 U37122 
                 0.003096 
                 0.002135 
                 0.000571 
                 −0.59281 
                 ADD3 
               
               
                 AA903720 
                 0.003096 
                 0.002135 
                 0.002557 
                 0.244618 
                 BAP29 
               
               
                 M93107 
                 0.003096 
                 0.002135 
                 0.00187 
                 −0.19146 
                 BDH 
               
               
                 M17754 
                 0.003096 
                 0.002135 
                 0.010333 
                 −0.10769 
                 BN51T 
               
               
                 X15882 
                 0.003096 
                 0.002135 
                 0.0023 
                 0.227769 
                 COL6A2 
               
               
                 D15057 
                 0.003096 
                 0.002135 
                 0.002814 
                 −0.26776 
                 DAD1 
               
               
                 S62138 
                 0.003096 
                 0.002135 
                 0.002442 
                 1.1158 
                 DDIT3 
               
               
                 AB026436 
                 0.003096 
                 0.002135 
                 0.011189 
                 0.711919 
                 DUSP10 
               
               
                 W27152 
                 0.003096 
                 0.002135 
                 0.009498 
                 −0.1614 
                 FLJ10569 
               
               
                 AB001106 
                 0.003096 
                 0.002135 
                 0.002408 
                 0.444617 
                 GMFB 
               
               
                 D87120 
                 0.003096 
                 0.002135 
                 0.00475 
                 0.236706 
                 GS3786 
               
               
                 AI200373 
                 0.003096 
                 0.002135 
                 0.003822 
                 −0.31066 
                 H2AFI 
               
               
                 U15085 
                 0.003096 
                 0.002135 
                 0.011743 
                 0.328857 
                 HLA-DMB 
               
               
                 U90549 
                 0.003096 
                 0.002135 
                 0.001654 
                 −0.26437 
                 HMG17L3 
               
               
                 AI760162 
                 0.003096 
                 0.002135 
                 0.001313 
                 −0.47775 
                 HT012 
               
               
                 AB018306 
                 0.003096 
                 0.002135 
                 0.000371 
                 0.316202 
                 KIAA0763 
               
               
                 D14696 
                 0.003096 
                 0.002135 
                 0.016949 
                 0.259239 
                 LAPTM4A 
               
               
                 U23852 
                 0.003096 
                 0.002135 
                 0.001207 
                 −0.2593 
                 LCK 
               
               
                 U70735 
                 0.003096 
                 0.002135 
                 0.0002 
                 −0.20846 
                 MOV34-34KD 
               
               
                 X79865 
                 0.003096 
                 0.002135 
                 0.0141 
                 0.418466 
                 MRPL12 
               
               
                 AI547258 
                 0.003096 
                 0.002135 
                 0.001223 
                 0.267951 
                 MT2A 
               
               
                 L40387 
                 0.003096 
                 0.002135 
                 0.00038 
                 0.211973 
                 OASL 
               
               
                 AB019517 
                 0.003096 
                 0.002135 
                 0.023004 
                 0.219453 
                 PKIG 
               
               
                 M58459 
                 0.003096 
                 0.002135 
                 0.001362 
                 1.46854 
                 RPS4Y 
               
               
                 X57348 
                 0.003096 
                 0.002135 
                 0.004255 
                 0.22047 
                 SFN 
               
               
                 M74558 
                 0.003096 
                 0.002135 
                 0.001205 
                 0.219185 
                 SIL 
               
               
                 U34044 
                 0.003096 
                 0.002135 
                 0.000831 
                 −0.21289 
                 SPS 
               
               
                 U49928 
                 0.003096 
                 0.002135 
                 0.000886 
                 −0.31189 
                 TAB1 
               
               
                 X05839 
                 0.003096 
                 0.002135 
                 0.008747 
                 0.214552 
                 TGFB1 
               
               
                 U16296 
                 0.003096 
                 0.002135 
                 0.006585 
                 −0.14857 
                 TIAM1 
               
               
                 U63127 
                 0.003096 
                 0.002135 
                 0.000538 
                 −0.38925 
                 TIC 
               
               
                 U03397 
                 0.003096 
                 0.002135 
                 0.005156 
                 −0.34157 
                 TNFRSF9 
               
               
                 M21624 
                 0.003096 
                 0.002135 
                 0.001748 
                 −0.51878 
                 TRD@ 
               
               
                 D83198 
                 0.003096 
                 0.002135 
                 0.028975 
                 −0.17519 
                 YF13H12 
               
               
                 HG960-HT960 
                 0.003096 
                 0.002135 
                 0.003089 
                 0.145701 
               
               
                 HG4724-HT5166 
                 0.003096 
                 0.002135 
                 0.002446 
                 −0.25728 
               
               
                 D00654 
                 0.003096 
                 0.004342 
                 9.79E−05 
                 −0.1819 
                 ACTG2 
               
               
                 U54645 
                 0.013622 
                 0.004342 
                 0.004228 
                 −0.25281 
                 AK2 
               
               
                 M93405 
                 0.003096 
                 0.004342 
                 0.020651 
                 0.126156 
                 ALDH6A1 
               
               
                 U73960 
                 0.003096 
                 0.004342 
                 0.002279 
                 0.555806 
                 ARL4 
               
               
                 U26455 
                 0.003096 
                 0.004342 
                 0.006562 
                 −0.53911 
                 ATM 
               
               
                 M33519 
                 0.003096 
                 0.004342 
                 0.011169 
                 −0.33327 
                 BAT3 
               
               
                 U90028 
                 0.003096 
                 0.004342 
                 0.000396 
                 −0.24971 
                 BICD1 
               
               
                 AB002384 
                 0.003096 
                 0.004342 
                 0.002855 
                 −0.46941 
                 C6orf32 
               
               
                 M74093 
                 0.003096 
                 0.004342 
                 0.000763 
                 −0.33022 
                 CCNE1 
               
               
                 AA203246 
                 0.003096 
                 0.004342 
                 0.007014 
                 −0.16607 
                 CDC2L5 
               
               
                 X66358 
                 0.013622 
                 0.004342 
                 0.007122 
                 −0.1886 
                 CDKL1 
               
               
                 U30872 
                 0.003096 
                 0.004342 
                 0.001715 
                 −0.164 
                 CENPF 
               
               
                 AB020675 
                 0.013622 
                 0.004342 
                 0.002913 
                 −0.25056 
                 CNTNAP2 
               
               
                 M13207 
                 0.013622 
                 0.004342 
                 0.01388 
                 0.122241 
                 CSF2 
               
               
                 AA173896 
                 0.013622 
                 0.004342 
                 0.008401 
                 0.305133 
                 CYB5-M 
               
               
                 L78267 
                 0.003096 
                 0.004342 
                 0.04708 
                 0.103949 
                 D15S226E 
               
               
                 AL080120 
                 0.013622 
                 0.004342 
                 0.001834 
                 −0.12922 
                 DKFZP564O0423 
               
               
                 U13896 
                 0.013622 
                 0.004342 
                 0.020482 
                 −0.10291 
                 DLG1 
               
               
                 AF034970 
                 0.013622 
                 0.004342 
                 0.010371 
                 −0.10568 
                 DOK2 
               
               
                 D12686 
                 0.013622 
                 0.004342 
                 0.003493 
                 0.170378 
                 EIF4G1 
               
               
                 AB002386 
                 0.003096 
                 0.004342 
                 0.000131 
                 −0.39255 
                 EZH1 
               
               
                 M15059 
                 0.003096 
                 0.004342 
                 0.002497 
                 0.2061 
                 FCER2 
               
               
                 W27545 
                 0.013622 
                 0.004342 
                 0.004445 
                 0.379682 
                 FLJ20259 
               
               
                 M84443 
                 0.003096 
                 0.004342 
                 0.000101 
                 −0.27085 
                 GALK2 
               
               
                 AF029777 
                 0.013622 
                 0.004342 
                 0.001427 
                 −0.22426 
                 GCN5L2 
               
               
                 D63876 
                 0.013622 
                 0.004342 
                 0.002737 
                 0.396946 
                 GGA3 
               
               
                 AB020645 
                 0.003096 
                 0.004342 
                 0.003907 
                 −0.37377 
                 GLS 
               
               
                 U77948 
                 0.003096 
                 0.004342 
                 0.000818 
                 −0.35677 
                 GTF2I 
               
               
                 AF035555 
                 0.003096 
                 0.004342 
                 0.018388 
                 −0.17666 
                 HADH2 
               
               
                 AF055001 
                 0.003096 
                 0.004342 
                 0.010744 
                 0.724714 
                 HERPUD1 
               
               
                 D32129 
                 0.003096 
                 0.004342 
                 0.005364 
                 −0.13287 
                 HLA-A 
               
               
                 AF043586 
                 0.003096 
                 0.004342 
                 0.001047 
                 −0.30021 
                 IGL@ 
               
               
                 U53831 
                 0.013622 
                 0.004342 
                 0.01853 
                 0.488267 
                 IRF7 
               
               
                 AB002344 
                 0.003096 
                 0.004342 
                 0.001658 
                 0.705775 
                 KIAA0346 
               
               
                 AI677689 
                 0.013622 
                 0.004342 
                 0.004375 
                 −0.1411 
                 KIAA0685 
               
               
                 AB023153 
                 0.003096 
                 0.004342 
                 0.04282 
                 −0.39134 
                 KIAA0936 
               
               
                 AB023226 
                 0.003096 
                 0.004342 
                 0.000111 
                 −0.71413 
                 KIAA1009 
               
               
                 AI148772 
                 0.013622 
                 0.004342 
                 0.03739 
                 0.532454 
                 KYNU 
               
               
                 AB006780 
                 0.003096 
                 0.004342 
                 0.010236 
                 0.178362 
                 LGALS3 
               
               
                 AL050405 
                 0.003096 
                 0.004342 
                 0.008144 
                 0.311843 
                 LOC51634 
               
               
                 L35253 
                 0.013622 
                 0.004342 
                 0.001324 
                 −0.46397 
                 MAPK14 
               
               
                 R93527 
                 0.013622 
                 0.004342 
                 0.000372 
                 0.264207 
                 MT1H 
               
               
                 AF108145 
                 0.003096 
                 0.004342 
                 0.001206 
                 −0.14877 
                 MYLE 
               
               
                 M96980 
                 0.013622 
                 0.004342 
                 0.002106 
                 −0.16409 
                 MYT1 
               
               
                 S76638 
                 0.013622 
                 0.004342 
                 0.04529 
                 0.171344 
                 NFKB2 
               
               
                 D88674 
                 0.013622 
                 0.004342 
                 0.045232 
                 0.346415 
                 OAZIN 
               
               
                 AL050353 
                 0.013622 
                 0.004342 
                 0.016071 
                 −0.11979 
                 OIP2 
               
               
                 AL080119 
                 0.003096 
                 0.004342 
                 0.001961 
                 −0.40821 
                 PAI-RBP1 
               
               
                 X76770 
                 0.013622 
                 0.004342 
                 0.005011 
                 −0.10613 
                 PAPOLA 
               
               
                 D11466 
                 0.003096 
                 0.004342 
                 0.009752 
                 0.738127 
                 PIGA 
               
               
                 W28299 
                 0.003096 
                 0.004342 
                 0.001225 
                 −0.17755 
                 PINK1 
               
               
                 U83981 
                 0.003096 
                 0.004342 
                 0.014327 
                 0.28747 
                 PPP1R15A 
               
               
                 X14968 
                 0.013622 
                 0.004342 
                 0.004727 
                 0.105215 
                 PRKAR2A 
               
               
                 M55284 
                 0.003096 
                 0.004342 
                 0.003435 
                 −0.17401 
                 PRKCH 
               
               
                 M15036 
                 0.003096 
                 0.004342 
                 0.010965 
                 −0.25119 
                 PROS1 
               
               
                 Y00638 
                 0.003096 
                 0.004342 
                 0.004977 
                 −0.30956 
                 PTPRC 
               
               
                 Y00815 
                 0.003096 
                 0.004342 
                 0.015344 
                 0.116938 
                 PTPRF 
               
               
                 M38258 
                 0.003096 
                 0.004342 
                 0.009252 
                 −0.14193 
                 RARG 
               
               
                 AF025654 
                 0.003096 
                 0.004342 
                 0.002302 
                 −0.39122 
                 RNGTT 
               
               
                 M60724 
                 0.013622 
                 0.004342 
                 0.004732 
                 −0.22065 
                 RPS6KB1 
               
               
                 AB006202 
                 0.013622 
                 0.004342 
                 0.003028 
                 −0.18268 
                 SDHD 
               
               
                 AA890010 
                 0.003096 
                 0.004342 
                 0.00546 
                 −0.21285 
                 SEC22L1 
               
               
                 X62822 
                 0.003096 
                 0.004342 
                 0.039707 
                 −0.21593 
                 SIAT1 
               
               
                 L41680 
                 0.003096 
                 0.004342 
                 0.001771 
                 −0.16486 
                 SIAT8D 
               
               
                 X15217 
                 0.003096 
                 0.004342 
                 0.007377 
                 0.149306 
                 SKIL 
               
               
                 L13857 
                 0.003096 
                 0.004342 
                 0.005721 
                 −0.11073 
                 SOS1 
               
               
                 U09564 
                 0.003096 
                 0.004342 
                 0.001203 
                 −0.27717 
                 SRPK1 
               
               
                 Z75330 
                 0.013622 
                 0.004342 
                 0.031796 
                 −0.11359 
                 STAG1 
               
               
                 X92762 
                 0.003096 
                 0.004342 
                 0.001021 
                 −0.27946 
                 TAZ 
               
               
                 AF064090 
                 0.003096 
                 0.004342 
                 0.006206 
                 0.303013 
                 TNFSF14 
               
               
                 U47634 
                 0.003096 
                 0.004342 
                 0.0057 
                 0.278205 
                 TUBB4 
               
               
                 L27071 
                 0.003096 
                 0.004342 
                 0.000732 
                 −0.39906 
                 TXK 
               
               
                 D78514 
                 0.003096 
                 0.004342 
                 0.000681 
                 −0.2599 
                 UBE2G1 
               
               
                 AF085807 
                 0.003096 
                 0.004342 
                 0.005801 
                 0.124457 
                 UPK1A 
               
               
                 U66561 
                 0.003096 
                 0.004342 
                 0.002542 
                 0.448044 
                 ZNF184 
               
               
                 X78925 
                 0.013622 
                 0.004342 
                 0.001898 
                 0.351929 
                 ZNF267 
               
               
                 HG2510-HT2606 
                 0.013622 
                 0.004342 
                 0.007016 
                 0.179499 
               
               
                 W27419 
                 0.003096 
                 0.004342 
                 0.006325 
                 0.341787 
               
               
                 AF054589 
                 0.003096 
                 0.004342 
                 0.030568 
                 −0.50762 
               
               
                 H98552 
                 0.003096 
                 0.004342 
                 0.017185 
                 −0.1057 
               
               
                 AI056697 
                 0.003096 
                 0.004342 
                 0.000329 
                 −0.20147 
               
               
                 X00351 
                 0.003096 
                 0.005207 
                 0.001506 
                 −0.12928 
                 ACTB 
               
               
                 AF006082 
                 0.003096 
                 0.005207 
                 0.002797 
                 −0.34587 
                 ACTR2 
               
               
                 Y09443 
                 0.003096 
                 0.005207 
                 0.002286 
                 −0.17646 
                 AGPS 
               
               
                 U22961 
                 0.003096 
                 0.005207 
                 0.003092 
                 0.147932 
                 ALB 
               
               
                 AF002163 
                 0.003096 
                 0.005207 
                 0.002447 
                 −0.37588 
                 AP3D1 
               
               
                 D87461 
                 0.003096 
                 0.005207 
                 0.004809 
                 −0.26338 
                 BCL2L2 
               
               
                 AF013759 
                 0.003096 
                 0.005207 
                 0.004946 
                 −0.18574 
                 CALU 
               
               
                 L22005 
                 0.003096 
                 0.005207 
                 0.006442 
                 0.131869 
                 CDC34 
               
               
                 AL109689 
                 0.003096 
                 0.005207 
                 0.013291 
                 −0.24945 
                 CGI-142 
               
               
                 U91543 
                 0.003096 
                 0.005207 
                 0.014143 
                 −0.25258 
                 CHD3 
               
               
                 X82153 
                 0.003096 
                 0.005207 
                 0.013882 
                 −0.31742 
                 CTSK 
               
               
                 AJ001687 
                 0.003096 
                 0.005207 
                 0.000224 
                 −0.64837 
                 D12S2489E 
               
               
                 M13149 
                 0.003096 
                 0.005207 
                 0.008717 
                 −0.13824 
                 HRG 
               
               
                 Y10313 
                 0.003096 
                 0.005207 
                 0.006846 
                 0.464769 
                 IFRD1 
               
               
                 D63485 
                 0.003096 
                 0.005207 
                 0.000985 
                 −0.31599 
                 IKKE 
               
               
                 D87077 
                 0.003096 
                 0.005207 
                 0.043072 
                 −0.21138 
                 KIAA0240 
               
               
                 AB007864 
                 0.003096 
                 0.005207 
                 0.001569 
                 0.256672 
                 KIAA0404 
               
               
                 X75346 
                 0.003096 
                 0.005207 
                 0.001841 
                 0.331699 
                 MAPKALPK2 
               
               
                 L07648 
                 0.003096 
                 0.005207 
                 0.010594 
                 0.226817 
                 MXI1 
               
               
                 AB028993 
                 0.003096 
                 0.005207 
                 0.0247 
                 0.133216 
                 NLGN1 
               
               
                 D45333 
                 0.003096 
                 0.005207 
                 0.002104 
                 0.302454 
                 PFDN1 
               
               
                 M65254 
                 0.003096 
                 0.005207 
                 0.002619 
                 0.262897 
                 PPP2R1B 
               
               
                 M86852 
                 0.003096 
                 0.005207 
                 0.004274 
                 0.172251 
                 PXMP3 
               
               
                 X97795 
                 0.003096 
                 0.005207 
                 0.021131 
                 −0.18349 
                 RAD54L 
               
               
                 U14970 
                 0.003096 
                 0.005207 
                 0.001894 
                 −0.1353 
                 RPS5 
               
               
                 X74570 
                 0.003096 
                 0.005207 
                 0.00345 
                 0.210049 
                 SIAT4C 
               
               
                 X98248 
                 0.003096 
                 0.005207 
                 0.010403 
                 −0.50617 
                 SORT1 
               
               
                 U17714 
                 0.003096 
                 0.005207 
                 0.002081 
                 −0.19372 
                 ST13 
               
               
                 W28869 
                 0.003096 
                 0.005207 
                 0.001369 
                 −0.38498 
                 TEGT 
               
               
                 M12125 
                 0.003096 
                 0.005207 
                 0.000178 
                 −0.09929 
                 TPM2 
               
               
                 L27071 
                 0.003096 
                 0.005207 
                 0.003834 
                 −0.36074 
                 TXK 
               
               
                 M60614 
                 0.003096 
                 0.005207 
                 0.001757 
                 −0.25283 
                 WIT-1 
               
               
                 HG4074-HT4344 
                 0.003096 
                 0.005207 
                 0.004175 
                 0.589048 
               
               
                 AL031846 
                 0.003096 
                 0.005207 
                 0.004012 
                 −0.42132 
               
               
                 HG1980-HT2023 
                 0.003096 
                 0.005207 
                 0.002314 
                 0.711234 
               
               
                 AF022853 
                 0.047678 
                 0.006683 
                 0.002056 
                 −0.30792 
                 ABCC1 
               
               
                 X02994 
                 0.047678 
                 0.006683 
                 0.036598 
                 −0.12393 
                 ADA 
               
               
                 D25304 
                 0.047678 
                 0.006683 
                 0.002258 
                 −0.44746 
                 ARHGEF6 
               
               
                 M23115 
                 0.047678 
                 0.006683 
                 0.016518 
                 −0.1243 
                 ATP2A2 
               
               
                 U87408 
                 0.047678 
                 0.006683 
                 0.008628 
                 −0.33961 
                 B1 
               
               
                 AA135683 
                 0.047678 
                 0.006683 
                 0.010045 
                 0.6329 
                 BASP1 
               
               
                 M22491 
                 0.047678 
                 0.006683 
                 0.020141 
                 −0.10386 
                 BMP3 
               
               
                 M28170 
                 0.047678 
                 0.006683 
                 0.014303 
                 0.280093 
                 CD19 
               
               
                 M16336 
                 0.047678 
                 0.006683 
                 0.011755 
                 −0.19993 
                 CD2 
               
               
                 U37022 
                 0.047678 
                 0.006683 
                 0.028135 
                 −0.06885 
                 CDK4 
               
               
                 U66469 
                 0.047678 
                 0.006683 
                 0.004123 
                 0.616896 
                 CGR19 
               
               
                 AI037867 
                 0.047678 
                 0.006683 
                 0.009634 
                 −0.11973 
                 CKTSF1B1 
               
               
                 J03071 
                 0.047678 
                 0.006683 
                 0.011153 
                 −0.23776 
                 CSH2 
               
               
                 M55265 
                 0.047678 
                 0.006683 
                 0.01278 
                 −0.1479 
                 CSNK2A1 
               
               
                 M33317 
                 0.047678 
                 0.006683 
                 0.014832 
                 −0.17753 
                 CYP2A7 
               
               
                 U37143 
                 0.013622 
                 0.006683 
                 0.001908 
                 0.171138 
                 CYP2J2 
               
               
                 AL049942 
                 0.013622 
                 0.006683 
                 0.00076 
                 −0.20245 
                 DKFZP564F1422 
               
               
                 AL050015 
                 0.013622 
                 0.006683 
                 0.008524 
                 −0.13959 
                 DKFZP564O243 
               
               
                 L35594 
                 0.013622 
                 0.006683 
                 0.002806 
                 0.216985 
                 ENPP2 
               
               
                 J03796 
                 0.047678 
                 0.006683 
                 0.002596 
                 −0.28198 
                 EPB41 
               
               
                 AC002398 
                 0.013622 
                 0.006683 
                 0.003226 
                 −0.27062 
                 F25965 
               
               
                 X15376 
                 0.013622 
                 0.006683 
                 0.014388 
                 −0.15607 
                 GABRG2 
               
               
                 M90656 
                 0.047678 
                 0.006683 
                 0.006961 
                 −0.15968 
                 GCLC 
               
               
                 AF062006 
                 0.013622 
                 0.006683 
                 0.001442 
                 0.200117 
                 GPR49 
               
               
                 X61755 
                 0.013622 
                 0.006683 
                 0.000491 
                 −0.19331 
                 HOXC5 
               
               
                 D21851 
                 0.047678 
                 0.006683 
                 0.017915 
                 0.153927 
                 KIAA0028 
               
               
                 AB007976 
                 0.047678 
                 0.006683 
                 0.032427 
                 0.228873 
                 KIAA0507 
               
               
                 AI871396 
                 0.047678 
                 0.006683 
                 0.001957 
                 −0.48312 
                 KIAA0557 
               
               
                 AB020660 
                 0.047678 
                 0.006683 
                 0.001858 
                 −0.27616 
                 KIAA0853 
               
               
                 X93595 
                 0.047678 
                 0.006683 
                 0.026214 
                 0.245064 
                 KIR3DL2 
               
               
                 AB002405 
                 0.047678 
                 0.006683 
                 0.003681 
                 −0.19481 
                 LAK-4P 
               
               
                 X07228 
                 0.047678 
                 0.006683 
                 0.046458 
                 0.113484 
                 LIPC 
               
               
                 U50529 
                 0.047678 
                 0.006683 
                 0.001977 
                 0.310499 
                 LOC88523 
               
               
                 AF040963 
                 0.047678 
                 0.006683 
                 0.012629 
                 0.148739 
                 MAD4 
               
               
                 U59423 
                 0.047678 
                 0.006683 
                 0.01126 
                 −0.1341 
                 MADH1 
               
               
                 U85430 
                 0.013622 
                 0.006683 
                 0.000224 
                 −0.41454 
                 NFATC3 
               
               
                 X80878 
                 0.047678 
                 0.006683 
                 0.010021 
                 −0.16096 
                 NFRKB 
               
               
                 AF005043 
                 0.013622 
                 0.006683 
                 0.00078 
                 −0.15296 
                 PARG 
               
               
                 D49818 
                 0.047678 
                 0.006683 
                 0.021976 
                 −0.10631 
                 PFKFB4 
               
               
                 M28393 
                 0.013622 
                 0.006683 
                 0.003241 
                 −0.16419 
                 PRF1 
               
               
                 Y00062 
                 0.047678 
                 0.006683 
                 0.011868 
                 −0.2415 
                 PTPRC 
               
               
                 L07758 
                 0.047678 
                 0.006683 
                 0.008943 
                 0.201883 
                 PWP1 
               
               
                 U57094 
                 0.047678 
                 0.006683 
                 0.014944 
                 −0.31108 
                 RAB27A 
               
               
                 M35416 
                 0.013622 
                 0.006683 
                 0.002789 
                 −0.41233 
                 RALB 
               
               
                 X75042 
                 0.047678 
                 0.006683 
                 0.003614 
                 0.659166 
                 REL 
               
               
                 AF038250 
                 0.047678 
                 0.006683 
                 0.004198 
                 0.395171 
                 SFRS3 
               
               
                 L27213 
                 0.013622 
                 0.006683 
                 0.001014 
                 −0.13065 
                 SLC4A3 
               
               
                 Y09568 
                 0.047678 
                 0.006683 
                 0.005799 
                 −0.3407 
                 SNAP23 
               
               
                 AA205857 
                 0.013622 
                 0.006683 
                 0.00048 
                 0.27495 
                 SNRPD3 
               
               
                 U07794 
                 0.047678 
                 0.006683 
                 0.007632 
                 −0.20733 
                 TXK 
               
               
                 J05428 
                 0.013622 
                 0.006683 
                 0.00573 
                 −0.08342 
                 UGT2B7 
               
               
                 U09848 
                 0.047678 
                 0.006683 
                 0.011538 
                 −0.26846 
                 ZNF36 
               
               
                 J00287 
                 0.047678 
                 0.006683 
                 0.000953 
                 −0.28381 
               
               
                 AB007882 
                 0.013622 
                 0.009369 
                 0.006034 
                 −0.17275 
                 ADCY6 
               
               
                 AF072810 
                 0.013622 
                 0.009369 
                 0.016137 
                 −0.32509 
                 BAZ1B 
               
               
                 AB004066 
                 0.013622 
                 0.009369 
                 0.00789 
                 0.494455 
                 BHLHB2 
               
               
                 U37547 
                 0.013622 
                 0.009369 
                 0.00478 
                 0.544595 
                 BIRC2 
               
               
                 AB024704 
                 0.013622 
                 0.009369 
                 0.010893 
                 −0.11914 
                 C20orf1 
               
               
                 AC004084 
                 0.013622 
                 0.009369 
                 0.005491 
                 −0.17437 
                 CAPRI 
               
               
                 L12691 
                 0.013622 
                 0.009369 
                 0.018291 
                 −0.18848 
                 DEFA3 
               
               
                 L19161 
                 0.013622 
                 0.009369 
                 0.001645 
                 −0.27253 
                 EIF2S3 
               
               
                 M82882 
                 0.013622 
                 0.009369 
                 0.003966 
                 0.478256 
                 ELF1 
               
               
                 X81625 
                 0.013622 
                 0.009369 
                 0.003918 
                 0.762544 
                 ETF1 
               
               
                 M15059 
                 0.013622 
                 0.009369 
                 0.035106 
                 0.313247 
                 FCER2 
               
               
                 AA284298 
                 0.013622 
                 0.009369 
                 0.028745 
                 −0.12535 
                 FLJ22269 
               
               
                 U13044 
                 0.013622 
                 0.009369 
                 0.017986 
                 −0.32813 
                 GABPA 
               
               
                 Z12173 
                 0.013622 
                 0.009369 
                 0.001297 
                 −0.32703 
                 GNS 
               
               
                 U06631 
                 0.013622 
                 0.009369 
                 0.003506 
                 −0.37935 
                 H326 
               
               
                 X75315 
                 0.013622 
                 0.009369 
                 0.002959 
                 1.06191 
                 HSRNASEB 
               
               
                 AF064084 
                 0.013622 
                 0.009369 
                 0.017927 
                 −0.10308 
                 ICMT 
               
               
                 AB002330 
                 0.013622 
                 0.009369 
                 0.048512 
                 −0.09076 
                 KIAA0332 
               
               
                 AB014569 
                 0.013622 
                 0.009369 
                 0.010011 
                 0.709572 
                 KIAA0669 
               
               
                 AI970189 
                 0.013622 
                 0.009369 
                 0.001778 
                 0.569801 
                 KIAA0997 
               
               
                 AB028960 
                 0.013622 
                 0.009369 
                 0.001825 
                 −0.15403 
                 KIAA1037 
               
               
                 AJ005273 
                 0.013622 
                 0.009369 
                 0.001449 
                 0.379277 
                 KIN 
               
               
                 L00352 
                 0.013622 
                 0.009369 
                 0.004231 
                 0.554465 
                 LDLR 
               
               
                 X54304 
                 0.013622 
                 0.009369 
                 0.000863 
                 −0.19567 
                 MLCB 
               
               
                 AI693193 
                 0.013622 
                 0.009369 
                 0.023978 
                 −0.25831 
                 MTX1 
               
               
                 AF047487 
                 0.013622 
                 0.009369 
                 0.001312 
                 −0.33746 
                 NCK2 
               
               
                 AF037448 
                 0.013622 
                 0.009369 
                 0.00743 
                 0.204106 
                 NSAP1 
               
               
                 AF000152 
                 0.013622 
                 0.009369 
                 0.025216 
                 −0.34592 
                 OS4 
               
               
                 U02882 
                 0.013622 
                 0.009369 
                 0.017536 
                 0.892321 
                 PDE4D 
               
               
                 X89416 
                 0.013622 
                 0.009369 
                 0.005129 
                 −0.1405 
                 PPP5C 
               
               
                 U27516 
                 0.013622 
                 0.009369 
                 0.004164 
                 −0.17553 
                 RAD52 
               
               
                 D23660 
                 0.013622 
                 0.009369 
                 0.01215 
                 0.149327 
                 RPL4 
               
               
                 AB016247 
                 0.013622 
                 0.009369 
                 0.019879 
                 0.416634 
                 SC5DL 
               
               
                 U44754 
                 0.013622 
                 0.009369 
                 0.005273 
                 0.158396 
                 SNAPC1 
               
               
                 AI660929 
                 0.013622 
                 0.009369 
                 0.000698 
                 −0.15764 
                 T1A-2 
               
               
                 X01060 
                 0.013622 
                 0.009369 
                 0.005079 
                 0.27369 
                 TFRC 
               
               
                 J02973 
                 0.013622 
                 0.009369 
                 0.006825 
                 0.835338 
                 THBD 
               
               
                 L41690 
                 0.013622 
                 0.009369 
                 0.020209 
                 −0.32814 
                 TRADD 
               
               
                 X89066 
                 0.013622 
                 0.009369 
                 0.000396 
                 −0.2226 
                 TRPC1 
               
               
                 AB024327 
                 0.013622 
                 0.009369 
                 0.031 
                 0.260875 
                 UNRIP 
               
               
                 AF033199 
                 0.013622 
                 0.009369 
                 0.02842 
                 −0.1806 
                 ZNF204 
               
               
                 AL080123 
                 0.013622 
                 0.009369 
                 0.018447 
                 0.215445 
                 ZNF23 
               
               
                 AB007885 
                 0.013622 
                 0.009369 
                 0.025803 
                 −0.22701 
                 ZNF262 
               
               
                 U40462 
                 0.013622 
                 0.009369 
                 0.004101 
                 −0.29722 
                 ZNFN1A1 
               
               
                 HG3477-HT3670 
                 0.013622 
                 0.009369 
                 0.00042 
                 −0.2367 
               
               
                 L42324 
                 0.013622 
                 0.009369 
                 0.015195 
                 0.283048 
                 GPR18 
               
               
                 AA975427 
                 0.013622 
                 0.009369 
                 0.002377 
                 −0.26992 
               
               
                 AL049957 
                 0.013622 
                 0.009369 
                 0.007809 
                 0.133451 
               
               
                 AL022398 
                 0.013622 
                 0.009369 
                 0.017529 
                 −0.48579 
               
               
                 HG2689-HT2785 
                 0.013622 
                 0.009369 
                 0.029818 
                 0.202486 
               
               
                 AF034373 
                 0.013622 
                 0.014679 
                 0.00591 
                 −0.26511 
                 A2LP 
               
               
                 X83467 
                 0.013622 
                 0.014679 
                 0.006111 
                 −0.25837 
                 ABCD3 
               
               
                 U41766 
                 0.047678 
                 0.014679 
                 0.014363 
                 0.473526 
                 ADAM9 
               
               
                 D67031 
                 0.013622 
                 0.014679 
                 0.007826 
                 −0.4645 
                 ADD3 
               
               
                 U84011 
                 0.013622 
                 0.014679 
                 0.012995 
                 −0.2499 
                 AGL 
               
               
                 M74088 
                 0.013622 
                 0.014679 
                 0.038601 
                 −0.16952 
                 APC 
               
               
                 U67092 
                 0.047678 
                 0.014679 
                 0.047381 
                 −0.10935 
                 ATM 
               
               
                 AI033692 
                 0.047678 
                 0.014679 
                 0.010056 
                 −0.2417 
                 BCRP1 
               
               
                 X92106 
                 0.013622 
                 0.014679 
                 0.001377 
                 −0.33994 
                 BLMH 
               
               
                 Z22535 
                 0.047678 
                 0.014679 
                 0.021613 
                 −0.09832 
                 BMPR1A 
               
               
                 X79067 
                 0.047678 
                 0.014679 
                 0.0381 
                 0.14954 
                 BRF1 
               
               
                 X86098 
                 0.013622 
                 0.014679 
                 0.000807 
                 −0.34829 
                 BS69 
               
               
                 U72649 
                 0.047678 
                 0.014679 
                 0.029157 
                 0.227444 
                 BTG2 
               
               
                 X95592 
                 0.047678 
                 0.014679 
                 0.014127 
                 0.201273 
                 C1D 
               
               
                 D78586 
                 0.047678 
                 0.014679 
                 0.028845 
                 −0.05709 
                 CAD 
               
               
                 D30742 
                 0.047678 
                 0.014679 
                 0.028215 
                 0.180381 
                 CAMK4 
               
               
                 AF035582 
                 0.047678 
                 0.014679 
                 0.002042 
                 0.530946 
                 CASK 
               
               
                 U60521 
                 0.047678 
                 0.014679 
                 0.002353 
                 0.552837 
                 CASP9 
               
               
                 AL035079 
                 0.013622 
                 0.014679 
                 0.00063 
                 −0.78567 
                 CAT 
               
               
                 AF094481 
                 0.047678 
                 0.014679 
                 0.024569 
                 0.149973 
                 CGGBP1 
               
               
                 X83378 
                 0.013622 
                 0.014679 
                 0.025603 
                 0.133485 
                 CLCN6 
               
               
                 AB002332 
                 0.047678 
                 0.014679 
                 0.003136 
                 −0.20009 
                 CLOCK 
               
               
                 D13146 
                 0.013622 
                 0.014679 
                 0.017967 
                 −0.13385 
                 CNP 
               
               
                 S80864 
                 0.013622 
                 0.014679 
                 0.011106 
                 −0.33164 
                 CYCL 
               
               
                 D17530 
                 0.047678 
                 0.014679 
                 0.005519 
                 −0.15234 
                 DBN1 
               
               
                 U87947 
                 0.047678 
                 0.014679 
                 0.011279 
                 0.222382 
                 EMP3 
               
               
                 M60459 
                 0.047678 
                 0.014679 
                 0.010174 
                 −0.10156 
                 EPOR 
               
               
                 AB018247 
                 0.013622 
                 0.014679 
                 0.000348 
                 0.423577 
                 FE65L2 
               
               
                 AB028973 
                 0.013622 
                 0.014679 
                 0.046458 
                 −0.12088 
                 FLJ10883 
               
               
                 AL080172 
                 0.047678 
                 0.014679 
                 0.02693 
                 −0.063 
                 FLJ21919 
               
               
                 AF032886 
                 0.047678 
                 0.014679 
                 0.009814 
                 0.232307 
                 FOXO3A 
               
               
                 U00928 
                 0.047678 
                 0.014679 
                 0.01307 
                 −0.0915 
                 FUS 
               
               
                 M14660 
                 0.047678 
                 0.014679 
                 0.011038 
                 0.732462 
                 FUT10 
               
               
                 AI935146 
                 0.047678 
                 0.014679 
                 0.044653 
                 0.246267 
                 GALNT3 
               
               
                 U28811 
                 0.047678 
                 0.014679 
                 0.007572 
                 −0.21558 
                 GLG1 
               
               
                 AF001903 
                 0.013622 
                 0.014679 
                 0.001957 
                 −0.28636 
                 HADHSC 
               
               
                 Y09306 
                 0.047678 
                 0.014679 
                 0.045083 
                 −0.08024 
                 HIPK3 
               
               
                 AL022723 
                 0.047678 
                 0.014679 
                 0.041021 
                 0.165267 
                 HLA-G 
               
               
                 M80469 
                 0.013622 
                 0.014679 
                 0.037453 
                 −0.12099 
                 HLA-J 
               
               
                 M16937 
                 0.013622 
                 0.014679 
                 0.002262 
                 −0.13536 
                 HOXB7 
               
               
                 X98307 
                 0.013622 
                 0.014679 
                 0.011852 
                 −0.0908 
                 HSHUR7SEQ 
               
               
                 HG2855-HT2995 
                 0.047678 
                 0.014679 
                 0.030595 
                 0.16813 
                 HSP70 
               
               
                 X87949 
                 0.047678 
                 0.014679 
                 0.028569 
                 0.296273 
                 HSPA5 
               
               
                 W68830 
                 0.013622 
                 0.014679 
                 0.007971 
                 −0.22855 
                 HSPC022 
               
               
                 D49410 
                 0.047678 
                 0.014679 
                 0.040369 
                 0.153358 
                 HUMIL3RA12 
               
               
                 AL049470 
                 0.013622 
                 0.014679 
                 0.010492 
                 0.283688 
                 HYPB 
               
               
                 Y10659 
                 0.047678 
                 0.014679 
                 0.024205 
                 −0.1217 
                 IL13RA1 
               
               
                 X52015 
                 0.047678 
                 0.014679 
                 0.006637 
                 0.417081 
                 IL1RN 
               
               
                 AF047492 
                 0.047678 
                 0.014679 
                 0.002557 
                 0.25738 
                 IMPG1 
               
               
                 U96919 
                 0.013622 
                 0.014679 
                 0.003221 
                 −0.19947 
                 INPP4A 
               
               
                 U12897 
                 0.013622 
                 0.014679 
                 0.002496 
                 −0.15016 
                 IPW 
               
               
                 S62539 
                 0.013622 
                 0.014679 
                 0.012982 
                 −0.20615 
                 IRS1 
               
               
                 AF029778 
                 0.047678 
                 0.014679 
                 0.018006 
                 −0.14486 
                 JAG2 
               
               
                 W25934 
                 0.047678 
                 0.014679 
                 0.016925 
                 0.363279 
                 JTV1 
               
               
                 X56681 
                 0.047678 
                 0.014679 
                 0.004935 
                 0.713663 
                 JUND 
               
               
                 M64934 
                 0.047678 
                 0.014679 
                 0.003162 
                 −0.1823 
                 KEL 
               
               
                 D86975 
                 0.047678 
                 0.014679 
                 0.048475 
                 0.163408 
                 KIAA0222 
               
               
                 AB020701 
                 0.013622 
                 0.014679 
                 0.013946 
                 0.283086 
                 KIAA0894 
               
               
                 AB023141 
                 0.047678 
                 0.014679 
                 0.017326 
                 −0.33543 
                 KIAA0924 
               
               
                 AB023148 
                 0.013622 
                 0.014679 
                 0.016218 
                 −0.27496 
                 KIAA0931 
               
               
                 AB023227 
                 0.047678 
                 0.014679 
                 0.043542 
                 0.316063 
                 KIAA1010 
               
               
                 AB028963 
                 0.047678 
                 0.014679 
                 0.039194 
                 −0.12296 
                 KIAA1040 
               
               
                 AL080188 
                 0.047678 
                 0.014679 
                 0.016745 
                 −0.10387 
                 KIAA1775 
               
               
                 AJ224162 
                 0.013622 
                 0.014679 
                 0.002225 
                 −0.24337 
                 LAS 
               
               
                 L25931 
                 0.013622 
                 0.014679 
                 0.00482 
                 −0.2367 
                 LBR 
               
               
                 AC004410 
                 0.047678 
                 0.014679 
                 0.017457 
                 0.210096 
                 LOC56928 
               
               
                 AB009462 
                 0.047678 
                 0.014679 
                 0.012892 
                 0.131673 
                 LRP3 
               
               
                 AF077820 
                 0.013622 
                 0.014679 
                 0.003095 
                 −0.40005 
                 LRP5 
               
               
                 X59408 
                 0.047678 
                 0.014679 
                 0.018321 
                 −0.3029 
                 MCP 
               
               
                 L13773 
                 0.013622 
                 0.014679 
                 0.002741 
                 −0.18297 
                 MLLT2 
               
               
                 X82209 
                 0.047678 
                 0.014679 
                 0.010828 
                 0.178564 
                 MN1 
               
               
                 X96401 
                 0.013622 
                 0.014679 
                 0.001643 
                 0.317165 
                 MNT 
               
               
                 M30818 
                 0.047678 
                 0.014679 
                 0.032832 
                 0.292682 
                 MX2 
               
               
                 V00568 
                 0.013622 
                 0.014679 
                 0.008535 
                 −0.58978 
                 MYC 
               
               
                 D50692 
                 0.013622 
                 0.014679 
                 0.043374 
                 −0.20783 
                 MYCBP 
               
               
                 AB007191 
                 0.013622 
                 0.014679 
                 0.022026 
                 −0.18098 
                 MYCBP 
               
               
                 X17576 
                 0.013622 
                 0.014679 
                 0.001641 
                 −0.26027 
                 NCK1 
               
               
                 X61498 
                 0.013622 
                 0.014679 
                 0.006234 
                 0.307667 
                 NFKB2 
               
               
                 AF052093 
                 0.047678 
                 0.014679 
                 0.001318 
                 −0.31976 
                 NJMU-R1 
               
               
                 X00737 
                 0.047678 
                 0.014679 
                 0.037385 
                 0.219194 
                 NP 
               
               
                 U02020 
                 0.047678 
                 0.014679 
                 0.014866 
                 0.650286 
                 PBEF 
               
               
                 X66362 
                 0.047678 
                 0.014679 
                 0.006159 
                 0.137944 
                 PCTK3 
               
               
                 AF026086 
                 0.047678 
                 0.014679 
                 0.006555 
                 −0.18222 
                 PEX1 
               
               
                 L25441 
                 0.047678 
                 0.014679 
                 0.011907 
                 0.146471 
                 PGGT1B 
               
               
                 AL021366 
                 0.013622 
                 0.014679 
                 0.002775 
                 0.425217 
                 PHF1 
               
               
                 D85418 
                 0.013622 
                 0.014679 
                 0.004449 
                 −0.31688 
                 PIGC 
               
               
                 D30037 
                 0.047678 
                 0.014679 
                 0.001579 
                 −0.21226 
                 PITPNB 
               
               
                 AB006746 
                 0.047678 
                 0.014679 
                 0.0356 
                 0.189986 
                 PLSCR1 
               
               
                 AF054182 
                 0.013622 
                 0.014679 
                 0.002098 
                 −0.54761 
                 PMPCB 
               
               
                 S87759 
                 0.013622 
                 0.014679 
                 0.007522 
                 0.39052 
                 PPM1A 
               
               
                 M13057 
                 0.047678 
                 0.014679 
                 0.032523 
                 −0.19317 
                 PRH1 
               
               
                 M64992 
                 0.047678 
                 0.014679 
                 0.047326 
                 0.178696 
                 PSMA1 
               
               
                 X58288 
                 0.047678 
                 0.014679 
                 0.002633 
                 0.409542 
                 PTPRM 
               
               
                 AD000092 
                 0.047678 
                 0.014679 
                 0.028359 
                 0.137917 
                 RAD23A 
               
               
                 U79716 
                 0.013622 
                 0.014679 
                 0.003409 
                 0.195389 
                 RELN 
               
               
                 U69198 
                 0.047678 
                 0.014679 
                 0.048001 
                 0.085316 
                 RFNG 
               
               
                 AF117829 
                 0.047678 
                 0.014679 
                 0.003668 
                 0.377251 
                 RIPK2 
               
               
                 AF039029 
                 0.047678 
                 0.014679 
                 0.002146 
                 −0.28622 
                 RNUT1 
               
               
                 AW021542 
                 0.013622 
                 0.014679 
                 0.000677 
                 −0.29232 
                 SAP18 
               
               
                 U64197 
                 0.047678 
                 0.014679 
                 0.021124 
                 0.220476 
                 SCYA20 
               
               
                 AB023136 
                 0.013622 
                 0.014679 
                 0.00288 
                 −0.10963 
                 SEC15B 
               
               
                 AF055006 
                 0.013622 
                 0.014679 
                 0.011241 
                 0.238955 
                 SEC6 
               
               
                 Z46606 
                 0.047678 
                 0.014679 
                 0.005778 
                 −0.1566 
                 SMARCA3 
               
               
                 L25270 
                 0.047678 
                 0.014679 
                 0.002401 
                 −0.15644 
                 SMCX 
               
               
                 M60618 
                 0.013622 
                 0.014679 
                 0.006316 
                 0.235838 
                 SP100 
               
               
                 AI739308 
                 0.013622 
                 0.014679 
                 0.001861 
                 −0.57419 
                 SRP46 
               
               
                 U52960 
                 0.047678 
                 0.014679 
                 0.02599 
                 0.429086 
                 SURB7 
               
               
                 D50863 
                 0.013622 
                 0.014679 
                 0.006582 
                 −0.13005 
                 TESK1 
               
               
                 D64015 
                 0.013622 
                 0.014679 
                 0.007587 
                 −0.3629 
                 TIAL1 
               
               
                 AB001523 
                 0.047678 
                 0.014679 
                 0.027565 
                 0.164838 
                 TMEM1 
               
               
                 L21715 
                 0.013622 
                 0.014679 
                 0.000862 
                 0.309808 
                 TNNI2 
               
               
                 AF045583 
                 0.047678 
                 0.014679 
                 0.043887 
                 −0.16757 
                 TULP3 
               
               
                 AJ001340 
                 0.013622 
                 0.014679 
                 0.002396 
                 −0.17031 
                 U3-55K 
               
               
                 AB015344 
                 0.013622 
                 0.014679 
                 0.008107 
                 −0.31161 
                 UBQLN2 
               
               
                 J03824 
                 0.013622 
                 0.014679 
                 0.005864 
                 −0.18849 
                 UROS 
               
               
                 AF022789 
                 0.047678 
                 0.014679 
                 0.006582 
                 0.309267 
                 USP12 
               
               
                 U48801 
                 0.013622 
                 0.014679 
                 0.003849 
                 −0.17743 
                 VEGFB 
               
               
                 HG544-HT544 
                 0.047678 
                 0.014679 
                 0.010549 
                 0.454218 
               
               
                 S66666 
                 0.013622 
                 0.014679 
                 0.003364 
                 −0.14303 
               
               
                 AI687419 
                 0.047678 
                 0.014679 
                 0.039394 
                 −0.3657 
               
               
                 W28800 
                 0.047678 
                 0.014679 
                 0.004582 
                 0.270831 
               
               
                 AL080111 
                 0.013622 
                 0.014679 
                 0.001378 
                 −0.36029 
               
               
                 AF070536 
                 0.047678 
                 0.014679 
                 0.006685 
                 0.199364 
               
               
                 AF070633 
                 0.047678 
                 0.014679 
                 0.010142 
                 −0.1635 
               
               
                 AF054998 
                 0.013622 
                 0.014679 
                 0.007913 
                 −0.21157 
               
               
                 HG3725-HT3981 
                 0.047678 
                 0.014679 
                 0.027792 
                 −0.11953 
               
               
                 HG1614-HT1614 
                 0.013622 
                 0.014679 
                 0.006999 
                 −0.45233 
               
               
                 M22324 
                 0.013622 
                 0.01669 
                 0.009982 
                 0.283293 
                 ANPEP 
               
               
                 AC005955 
                 0.013622 
                 0.01669 
                 0.004346 
                 0.137324 
                 CEACAM4 
               
               
                 S68134 
                 0.013622 
                 0.01669 
                 0.005372 
                 1.92718 
                 CREM 
               
               
                 S68271 
                 0.013622 
                 0.01669 
                 0.009154 
                 1.49785 
                 CREM 
               
               
                 M24069 
                 0.013622 
                 0.01669 
                 0.003022 
                 0.249971 
                 CSDA 
               
               
                 AF000984 
                 0.013622 
                 0.01669 
                 0.004295 
                 0.46432 
                 DBY 
               
               
                 AF055917 
                 0.013622 
                 0.01669 
                 0.015434 
                 0.102855 
                 F2RL3 
               
               
                 U27333 
                 0.013622 
                 0.01669 
                 0.012662 
                 0.136047 
                 FUT6 
               
               
                 X89887 
                 0.013622 
                 0.01669 
                 0.009728 
                 0.152829 
                 HIRA 
               
               
                 L42243 
                 0.013622 
                 0.01669 
                 0.002638 
                 0.218644 
                 IFNAR2 
               
               
                 AI950382 
                 0.013622 
                 0.01669 
                 0.00744 
                 0.601631 
                 KIAA0585 
               
               
                 AI950382 
                 0.013622 
                 0.01669 
                 0.002126 
                 0.519735 
                 KIAA0585 
               
               
                 U17760 
                 0.013622 
                 0.01669 
                 0.044392 
                 0.431131 
                 LAMB3 
               
               
                 L48692 
                 0.013622 
                 0.01669 
                 0.041233 
                 0.63409 
                 LOC56902 
               
               
                 X94232 
                 0.013622 
                 0.01669 
                 0.016402 
                 0.326694 
                 MAPRE2 
               
               
                 AA037278 
                 0.013622 
                 0.01669 
                 0.01607 
                 0.119411 
                 MGC10882 
               
               
                 L13740 
                 0.013622 
                 0.01669 
                 0.007795 
                 0.355688 
                 NR4A1 
               
               
                 U12767 
                 0.013622 
                 0.01669 
                 0.011648 
                 1.30268 
                 NR4A3 
               
               
                 D78579 
                 0.013622 
                 0.01669 
                 0.005896 
                 1.11766 
                 NR4A3 
               
               
                 X17042 
                 0.013622 
                 0.01669 
                 0.015594 
                 0.239796 
                 PRG1 
               
               
                 U48296 
                 0.013622 
                 0.01669 
                 0.003124 
                 0.864101 
                 PTP4A1 
               
               
                 M83221 
                 0.013622 
                 0.01669 
                 0.012321 
                 0.192956 
                 RELB 
               
               
                 AF107463 
                 0.013622 
                 0.01669 
                 0.009662 
                 0.419254 
                 SPF30 
               
               
                 L47276 
                 0.013622 
                 0.01669 
                 0.004673 
                 0.194449 
                 TOP2A 
               
               
                 X00734 
                 0.013622 
                 0.01669 
                 0.010039 
                 0.347307 
                 TUBB5 
               
               
                 X51521 
                 0.013622 
                 0.01669 
                 0.010303 
                 0.60161 
                 VIL2 
               
               
                 S54641 
                 0.013622 
                 0.01669 
                 0.008483 
                 0.183207 
                 ZNF124 
               
               
                 M91029 
                 0.013622 
                 0.022759 
                 0.010686 
                 0.450612 
                 AMPD2 
               
               
                 AB021638 
                 0.136189 
                 0.022759 
                 0.024881 
                 −0.1126 
                 APBA3 
               
               
                 AL120559 
                 0.013622 
                 0.022759 
                 0.004505 
                 0.577915 
                 ARPP-19 
               
               
                 AF039656 
                 0.013622 
                 0.022759 
                 0.006991 
                 0.68481 
                 BASP1 
               
               
                 AB020623 
                 0.047678 
                 0.022759 
                 0.009696 
                 0.418826 
                 BCAS2 
               
               
                 X60201 
                 0.013622 
                 0.022759 
                 0.011758 
                 −0.1576 
                 BDNF 
               
               
                 U56637 
                 0.047678 
                 0.022759 
                 0.008899 
                 −0.28102 
                 CAPZA1 
               
               
                 AW043690 
                 0.047678 
                 0.022759 
                 0.031971 
                 0.134862 
                 CCK 
               
               
                 D13627 
                 0.047678 
                 0.022759 
                 0.019298 
                 0.203913 
                 CCT8 
               
               
                 U56998 
                 0.013622 
                 0.022759 
                 0.024403 
                 0.442545 
                 CNK 
               
               
                 U71267 
                 0.047678 
                 0.022759 
                 0.007233 
                 −0.13426 
                 CNOT4 
               
               
                 F27891 
                 0.047678 
                 0.022759 
                 0.02847 
                 0.119514 
                 COX6A2 
               
               
                 U78524 
                 0.013622 
                 0.022759 
                 0.002554 
                 0.353034 
                 DDXBP1 
               
               
                 AF043733 
                 0.047678 
                 0.022759 
                 0.005645 
                 0.22771 
                 DEDD 
               
               
                 X64229 
                 0.013622 
                 0.022759 
                 0.013033 
                 −0.20244 
                 DEK 
               
               
                 AL050284 
                 0.047678 
                 0.022759 
                 0.002819 
                 0.232244 
                 DKFZP586M1019 
               
               
                 L05147 
                 0.013622 
                 0.022759 
                 0.021168 
                 0.111752 
                 DUSP3 
               
               
                 U15642 
                 0.013622 
                 0.022759 
                 0.013339 
                 0.474421 
                 E2F5 
               
               
                 U31556 
                 0.047678 
                 0.022759 
                 0.011303 
                 0.335871 
                 E2F5 
               
               
                 AC004262 
                 0.047678 
                 0.022759 
                 0.004968 
                 −0.25642 
                 EMR2 
               
               
                 AA181196 
                 0.047678 
                 0.022759 
                 0.009459 
                 −0.10534 
                 FLJ11712 
               
               
                 U74612 
                 0.013622 
                 0.022759 
                 0.014802 
                 −0.18783 
                 FOXM1 
               
               
                 W28281 
                 0.013622 
                 0.022759 
                 0.011042 
                 0.813742 
                 GABARAPL1 
               
               
                 AI183417 
                 0.013622 
                 0.022759 
                 0.011016 
                 0.117979 
                 GABPB1 
               
               
                 L13720 
                 0.013622 
                 0.022759 
                 0.014471 
                 −0.1601 
                 GAS6 
               
               
                 X15722 
                 0.013622 
                 0.022759 
                 0.029451 
                 −0.19175 
                 GSR 
               
               
                 Y07595 
                 0.013622 
                 0.022759 
                 0.003113 
                 −0.20996 
                 GTF2H4 
               
               
                 L43821 
                 0.047678 
                 0.022759 
                 0.005863 
                 −0.20401 
                 HEF1 
               
               
                 L10379 
                 0.013622 
                 0.022759 
                 0.02006 
                 −0.15961 
                 HRIHFB2206 
               
               
                 X99209 
                 0.013622 
                 0.022759 
                 0.021333 
                 −0.14942 
                 HRMT1L1 
               
               
                 X77956 
                 0.013622 
                 0.022759 
                 0.009598 
                 0.591031 
                 ID1 
               
               
                 AL021707 
                 0.013622 
                 0.022759 
                 0.004161 
                 1.79061 
                 KIAA0063 
               
               
                 AB007896 
                 0.013622 
                 0.022759 
                 0.006273 
                 −0.41247 
                 KIAA0436 
               
               
                 AB014528 
                 0.047678 
                 0.022759 
                 0.001992 
                 −0.31837 
                 KIAA0628 
               
               
                 AB014607 
                 0.013622 
                 0.022759 
                 0.000764 
                 −0.15753 
                 KIAA0707 
               
               
                 AB018290 
                 0.013622 
                 0.022759 
                 0.034506 
                 −0.28703 
                 KIAA0747 
               
               
                 AB018337 
                 0.013622 
                 0.022759 
                 0.008466 
                 −0.41118 
                 KIAA0794 
               
               
                 AB023161 
                 0.013622 
                 0.022759 
                 0.018461 
                 −0.15095 
                 KIAA0944 
               
               
                 AB023202 
                 0.013622 
                 0.022759 
                 0.005879 
                 −0.19156 
                 KIAA0985 
               
               
                 U80743 
                 0.013622 
                 0.022759 
                 0.000544 
                 −0.30322 
                 KIAA1498 
               
               
                 X13794 
                 0.047678 
                 0.022759 
                 0.018671 
                 −0.12764 
                 LDHB 
               
               
                 Z34975 
                 0.013622 
                 0.022759 
                 0.012256 
                 −0.29089 
                 LDLC 
               
               
                 AI341656 
                 0.047678 
                 0.022759 
                 0.021482 
                 −0.26002 
                 LIM 
               
               
                 X87342 
                 0.013622 
                 0.022759 
                 0.006652 
                 −0.23382 
                 LLGL2 
               
               
                 U29671 
                 0.047678 
                 0.022759 
                 0.001133 
                 −0.2617 
                 MAP3K1 
               
               
                 Z14138 
                 0.013622 
                 0.022759 
                 0.00408 
                 0.81232 
                 MAP3K8 
               
               
                 AI743606 
                 0.013622 
                 0.022759 
                 0.00269 
                 −0.19764 
                 MEL 
               
               
                 AF052183 
                 0.013622 
                 0.022759 
                 0.002151 
                 −0.19631 
                 MGC2722 
               
               
                 AL050356 
                 0.013622 
                 0.022759 
                 0.002743 
                 −0.42417 
                 MINPP1 
               
               
                 AF041081 
                 0.013622 
                 0.022759 
                 0.019282 
                 −0.21627 
                 MN7 
               
               
                 U59302 
                 0.013622 
                 0.022759 
                 0.003859 
                 0.280175 
                 NCOA1 
               
               
                 W28360 
                 0.013622 
                 0.022759 
                 0.016633 
                 0.272057 
                 NCUBE1 
               
               
                 U97198 
                 0.013622 
                 0.022759 
                 0.001352 
                 −0.20163 
                 NLP_1 
               
               
                 AA194159 
                 0.013622 
                 0.022759 
                 0.004614 
                 −0.40044 
                 PEX10 
               
               
                 U38964 
                 0.013622 
                 0.022759 
                 0.004912 
                 −0.23793 
                 PMS2L8 
               
               
                 D38498 
                 0.013622 
                 0.022759 
                 0.003965 
                 −0.58306 
                 PMS2L9 
               
               
                 AA996066 
                 0.013622 
                 0.022759 
                 0.003514 
                 −0.21994 
                 PMS2L9 
               
               
                 AB029028 
                 0.013622 
                 0.022759 
                 0.027753 
                 −0.29778 
                 RAP140 
               
               
                 AA402524 
                 0.047678 
                 0.022759 
                 0.005359 
                 −0.11564 
                 RBM9 
               
               
                 U79745 
                 0.013622 
                 0.022759 
                 0.00409 
                 0.777629 
                 SLC16A6 
               
               
                 X98332 
                 0.013622 
                 0.022759 
                 0.002282 
                 −0.20078 
                 SLC22A1 
               
               
                 D42045 
                 0.013622 
                 0.022759 
                 0.006867 
                 −0.19726 
                 SNM1 
               
               
                 M76231 
                 0.013622 
                 0.022759 
                 0.009942 
                 0.13899 
                 SPR 
               
               
                 U76366 
                 0.013622 
                 0.022759 
                 0.015416 
                 −0.09378 
                 TCOF1 
               
               
                 U09087 
                 0.013622 
                 0.022759 
                 0.00607 
                 −0.26017 
                 TMPO 
               
               
                 AF049140 
                 0.047678 
                 0.022759 
                 0.011115 
                 −0.21894 
                 UBE2V2 
               
               
                 AF038962 
                 0.047678 
                 0.022759 
                 0.007219 
                 −0.44337 
                 VDAC3 
               
               
                 D84145 
                 0.013622 
                 0.022759 
                 0.002923 
                 0.574155 
                 WS-3 
               
               
                 Y09723 
                 0.047678 
                 0.022759 
                 0.001292 
                 0.234149 
                 ZNF151 
               
               
                 AL049991 
                 0.013622 
                 0.022759 
                 0.007094 
                 0.245237 
               
               
                 AL050148 
                 0.013622 
                 0.022759 
                 0.013128 
                 −0.26398 
               
               
                 AI014538 
                 0.013622 
                 0.022759 
                 0.003507 
                 −0.15278 
               
               
                 AI732885 
                 0.047678 
                 0.022759 
                 0.043886 
                 −0.10293 
               
               
                 U14573 
                 0.013622 
                 0.022759 
                 0.04259 
                 −0.11614 
               
               
                 U82987 
                 0.013622 
                 0.024606 
                 0.00343 
                 −0.17272 
                 BBC3 
               
               
                 L12168 
                 0.013622 
                 0.024606 
                 0.007944 
                 −0.22028 
                 CAP 
               
               
                 V00571 
                 0.013622 
                 0.024606 
                 0.005873 
                 0.132015 
                 CRH 
               
               
                 AL022398 
                 0.013622 
                 0.024606 
                 0.015005 
                 −0.44535 
                 DJ434O14.3 
               
               
                 AL080081 
                 0.013622 
                 0.024606 
                 0.007659 
                 0.548836 
                 DNAJB9 
               
               
                 X85116 
                 0.013622 
                 0.024606 
                 0.039531 
                 −0.24601 
                 EPB72 
               
               
                 AJ007669 
                 0.013622 
                 0.024606 
                 0.019404 
                 −0.23162 
                 FANCG 
               
               
                 AW024285 
                 0.013622 
                 0.024606 
                 0.007049 
                 0.311562 
                 FLJ12443 
               
               
                 W27666 
                 0.013622 
                 0.024606 
                 0.009544 
                 −0.25685 
                 FLJ14393 
               
               
                 AA908993 
                 0.013622 
                 0.024606 
                 0.015356 
                 −0.12684 
                 FLJ14393 
               
               
                 U90917 
                 0.013622 
                 0.024606 
                 0.016602 
                 −0.23386 
                 FOXM1 
               
               
                 AF017445 
                 0.013622 
                 0.024606 
                 0.025525 
                 −0.33517 
                 FPGT 
               
               
                 AJ238764 
                 0.013622 
                 0.024606 
                 0.030667 
                 0.197763 
                 GNE 
               
               
                 J04501 
                 0.013622 
                 0.024606 
                 0.007821 
                 −0.23523 
                 GYS1 
               
               
                 X56841 
                 0.013622 
                 0.024606 
                 0.022605 
                 −0.23469 
                 HLA-E 
               
               
                 M63438 
                 0.013622 
                 0.024606 
                 0.005389 
                 −0.75873 
                 IGKC 
               
               
                 S66213 
                 0.013622 
                 0.024606 
                 0.011362 
                 −0.09802 
                 ITGA6 
               
               
                 AB007870 
                 0.013622 
                 0.024606 
                 0.002855 
                 0.657213 
                 KIAA0410 
               
               
                 N29665 
                 0.013622 
                 0.024606 
                 0.008301 
                 −0.49779 
                 KIAA0618 
               
               
                 AB018353 
                 0.013622 
                 0.024606 
                 0.033864 
                 −0.3542 
                 KIAA0810 
               
               
                 D10522 
                 0.013622 
                 0.024606 
                 0.028464 
                 0.22227 
                 MACS 
               
               
                 AF004709 
                 0.013622 
                 0.024606 
                 0.018118 
                 −0.09931 
                 MAPK13 
               
               
                 W28275 
                 0.013622 
                 0.024606 
                 0.005871 
                 −0.27591 
                 MGC11061 
               
               
                 AF087020 
                 0.013622 
                 0.024606 
                 0.032064 
                 −0.13544 
                 MPZL1 
               
               
                 U61981 
                 0.013622 
                 0.024606 
                 0.012069 
                 −0.20932 
                 MSH3 
               
               
                 U90942 
                 0.013622 
                 0.024606 
                 0.004002 
                 0.179029 
                 MYO5A 
               
               
                 D50370 
                 0.013622 
                 0.024606 
                 0.008327 
                 −0.11492 
                 NAP1L3 
               
               
                 U91512 
                 0.013622 
                 0.024606 
                 0.00493 
                 0.549889 
                 NINJ1 
               
               
                 AF069987 
                 0.013622 
                 0.024606 
                 0.007336 
                 −0.16953 
                 NIT1 
               
               
                 U37689 
                 0.013622 
                 0.024606 
                 0.007097 
                 −0.17369 
                 POLR2H 
               
               
                 L19067 
                 0.013622 
                 0.024606 
                 0.006406 
                 0.148517 
                 RELA 
               
               
                 X13482 
                 0.013622 
                 0.024606 
                 0.016873 
                 0.241998 
                 SNRPA1 
               
               
                 D16827 
                 0.013622 
                 0.024606 
                 0.004314 
                 −0.16954 
                 SSTR5 
               
               
                 AB011420 
                 0.013622 
                 0.024606 
                 0.030791 
                 0.171669 
                 STK17A 
               
               
                 L39060 
                 0.013622 
                 0.024606 
                 0.026797 
                 −0.24028 
                 TAF1A 
               
               
                 AB011169 
                 0.013622 
                 0.024606 
                 0.004017 
                 −0.24355 
                 TEB4 
               
               
                 U69108 
                 0.013622 
                 0.024606 
                 0.024472 
                 −0.17595 
                 TRAF5 
               
               
                 AB011004 
                 0.013622 
                 0.024606 
                 0.00265 
                 1.03158 
                 UAP1 
               
               
                 AB014584 
                 0.013622 
                 0.024606 
                 0.028525 
                 −0.1337 
                 UBE4B 
               
               
                 HG3914-HT4184 
                 0.013622 
                 0.024606 
                 0.025854 
                 −0.12454 
               
               
                 Z32860 
                 0.013622 
                 0.024606 
                 0.002037 
                 −0.11041 
               
               
                 U25849 
                 0.013622 
                 0.024606 
                 0.00632 
                 −0.43498 
               
               
                 AF052100 
                 0.013622 
                 0.024606 
                 0.006718 
                 −0.2297 
               
               
                 X59268 
                 0.013622 
                 0.024606 
                 0.003586 
                 0.479423 
                 GTF2B 
               
               
                 AF007142 
                 0.013622 
                 0.024606 
                 0.01864 
                 −0.34584 
               
               
                 AI312646 
                 0.013622 
                 0.024606 
                 0.027596 
                 −0.14991 
               
               
                 AL022318 
                 0.047678 
                 0.028192 
                 0.049355 
                 −0.11704 
                 APOBEC1L 
               
               
                 M30704 
                 0.047678 
                 0.028192 
                 0.00926 
                 0.279668 
                 AREG 
               
               
                 AF001307 
                 0.047678 
                 0.028192 
                 0.018109 
                 −0.12594 
                 ARNT 
               
               
                 AB020680 
                 0.047678 
                 0.028192 
                 0.007009 
                 0.227256 
                 BAG5 
               
               
                 AF018631 
                 0.047678 
                 0.028192 
                 0.008344 
                 −0.13689 
                 BTD 
               
               
                 D64110 
                 0.047678 
                 0.028192 
                 0.022809 
                 0.398412 
                 BTG3 
               
               
                 Z11697 
                 0.047678 
                 0.028192 
                 0.024131 
                 0.750492 
                 CD83 
               
               
                 M31516 
                 0.047678 
                 0.028192 
                 0.021562 
                 0.517068 
                 DAF 
               
               
                 AF000982 
                 0.047678 
                 0.028192 
                 0.025357 
                 0.29808 
                 DDX3 
               
               
                 L77566 
                 0.047678 
                 0.028192 
                 0.01243 
                 0.178957 
                 DGSI 
               
               
                 AL096725 
                 0.047678 
                 0.028192 
                 0.007381 
                 0.436688 
                 DKFZP434B103 
               
               
                 AL080201 
                 0.047678 
                 0.028192 
                 0.044829 
                 −0.11576 
                 DKFZP434F162 
               
               
                 AL050286 
                 0.047678 
                 0.028192 
                 0.004267 
                 −0.22397 
                 DKFZP586A011 
               
               
                 Y13350 
                 0.047678 
                 0.028192 
                 0.015562 
                 0.137002 
                 DNAJA2 
               
               
                 AJ223333 
                 0.047678 
                 0.028192 
                 0.013836 
                 −0.17437 
                 DNMT2 
               
               
                 L34075 
                 0.047678 
                 0.028192 
                 0.013848 
                 −0.25236 
                 FRAP1 
               
               
                 D31766 
                 0.047678 
                 0.028192 
                 0.029287 
                 −0.09623 
                 GNPI 
               
               
                 Z80776 
                 0.047678 
                 0.028192 
                 0.002034 
                 0.143491 
                 H2AFG 
               
               
                 K03183 
                 0.047678 
                 0.028192 
                 0.040298 
                 0.163306 
                 HUMCGBBA3 
               
               
                 X57025 
                 0.047678 
                 0.028192 
                 0.009135 
                 0.437394 
                 IGF1 
               
               
                 X56681 
                 0.047678 
                 0.028192 
                 0.012885 
                 0.423181 
                 JUND 
               
               
                 AB007916 
                 0.047678 
                 0.028192 
                 0.00772 
                 −0.45744 
                 KIAA0447 
               
               
                 AI672098 
                 0.047678 
                 0.028192 
                 0.014331 
                 0.160649 
                 KIAA0934 
               
               
                 AB029020 
                 0.047678 
                 0.028192 
                 0.035285 
                 −0.3101 
                 KIAA1097 
               
               
                 W27233 
                 0.047678 
                 0.028192 
                 0.019918 
                 −0.24802 
                 KIDINS220 
               
               
                 AL049341 
                 0.047678 
                 0.028192 
                 0.001943 
                 −0.3086 
                 LOC57209 
               
               
                 AL049422 
                 0.047678 
                 0.028192 
                 0.028823 
                 0.264129 
                 LOC84549 
               
               
                 AF010193 
                 0.047678 
                 0.028192 
                 0.003729 
                 0.927225 
                 MADH7 
               
               
                 AF007134 
                 0.047678 
                 0.028192 
                 0.009151 
                 −0.1209 
                 MAPK8IP1 
               
               
                 L04731 
                 0.047678 
                 0.028192 
                 0.025599 
                 −0.07236 
                 MLL 
               
               
                 AB014547 
                 0.047678 
                 0.028192 
                 0.023787 
                 −0.15831 
                 MTMR4 
               
               
                 U91616 
                 0.047678 
                 0.028192 
                 0.018681 
                 0.377931 
                 NFKBIE 
               
               
                 X75918 
                 0.047678 
                 0.028192 
                 0.019713 
                 1.21948 
                 NR4A2 
               
               
                 AL049842 
                 0.047678 
                 0.028192 
                 0.022698 
                 0.201258 
                 NUFIP1 
               
               
                 U57843 
                 0.047678 
                 0.028192 
                 0.011796 
                 −0.13969 
                 PIK3CD 
               
               
                 S76965 
                 0.047678 
                 0.028192 
                 0.012413 
                 0.426208 
                 PKIA 
               
               
                 AL023553 
                 0.047678 
                 0.028192 
                 0.00321 
                 −0.15608 
                 PMM1 
               
               
                 M93425 
                 0.047678 
                 0.028192 
                 0.019899 
                 −0.36854 
                 PTPN12 
               
               
                 AF044968 
                 0.047678 
                 0.028192 
                 0.006887 
                 0.121898 
                 PVRL2 
               
               
                 M28211 
                 0.047678 
                 0.028192 
                 0.050065 
                 −0.08518 
                 RAB4 
               
               
                 AF083255 
                 0.047678 
                 0.028192 
                 0.021248 
                 −0.27368 
                 RNAHP 
               
               
                 U04897 
                 0.047678 
                 0.028192 
                 0.013893 
                 0.278167 
                 RORA 
               
               
                 AL031228 
                 0.047678 
                 0.028192 
                 0.020491 
                 −0.22382 
                 SACM2L 
               
               
                 Y08262 
                 0.047678 
                 0.028192 
                 0.008184 
                 −0.34195 
                 SCA2 
               
               
                 AF000652 
                 0.047678 
                 0.028192 
                 0.001533 
                 0.415218 
                 SDCBP 
               
               
                 D31891 
                 0.047678 
                 0.028192 
                 0.00536 
                 −0.18144 
                 SETDB1 
               
               
                 X66079 
                 0.047678 
                 0.028192 
                 0.008707 
                 0.129642 
                 SPIB 
               
               
                 Z96932 
                 0.047678 
                 0.028192 
                 0.013622 
                 −0.14003 
                 SSNA1 
               
               
                 D43642 
                 0.047678 
                 0.028192 
                 0.015302 
                 −0.26409 
                 TCFL1 
               
               
                 D50919 
                 0.047678 
                 0.028192 
                 0.016207 
                 −0.23972 
                 TRIM14 
               
               
                 X01703 
                 0.047678 
                 0.028192 
                 0.004339 
                 0.386096 
                 TUBA3 
               
               
                 AF022375 
                 0.047678 
                 0.028192 
                 0.015198 
                 0.503607 
                 VEGF 
               
               
                 AF062346 
                 0.047678 
                 0.028192 
                 0.014763 
                 0.455053 
                 ZNF216 
               
               
                 J04755 
                 0.047678 
                 0.028192 
                 0.014444 
                 0.302274 
               
               
                 AA524802 
                 0.047678 
                 0.028192 
                 0.036226 
                 −0.24775 
               
               
                 AL096749 
                 0.047678 
                 0.028192 
                 0.017041 
                 0.106309 
               
               
                 M21259 
                 0.047678 
                 0.028192 
                 0.025927 
                 0.18378 
               
               
                 X61587 
                 0.047678 
                 0.037364 
                 0.024028 
                 0.222788 
                 ARHG 
               
               
                 J04027 
                 0.047678 
                 0.037364 
                 0.019918 
                 0.336927 
                 ATP2B1 
               
               
                 W28091 
                 0.047678 
                 0.037364 
                 0.016936 
                 −0.1567 
                 BBS4 
               
               
                 U03106 
                 0.047678 
                 0.037364 
                 0.004064 
                 0.915096 
                 CDKN1A 
               
               
                 AL049924 
                 0.047678 
                 0.037364 
                 0.001517 
                 −0.23208 
                 DKFZP547G1110 
               
               
                 L19161 
                 0.047678 
                 0.037364 
                 0.006578 
                 −0.49859 
                 EIF2S3 
               
               
                 AF052123 
                 0.136189 
                 0.037364 
                 0.013524 
                 −0.24445 
                 FLJ10814 
               
               
                 AA522530 
                 0.047678 
                 0.037364 
                 0.038021 
                 0.413536 
                 FLJ20500 
               
               
                 AJ011001 
                 0.047678 
                 0.037364 
                 0.016436 
                 −0.63045 
                 GPR56 
               
               
                 U50079 
                 0.047678 
                 0.037364 
                 0.013178 
                 −0.37546 
                 HDAC1 
               
               
                 AI796944 
                 0.047678 
                 0.037364 
                 0.011597 
                 0.216392 
                 HIS1 
               
               
                 S82986 
                 0.047678 
                 0.037364 
                 0.006441 
                 −0.20652 
                 HOXC6 
               
               
                 AB011173 
                 0.047678 
                 0.037364 
                 0.01376 
                 −0.26283 
                 KIAA0601 
               
               
                 AB023160 
                 0.047678 
                 0.037364 
                 0.029467 
                 −0.23276 
                 KIAA0943 
               
               
                 AJ001685 
                 0.047678 
                 0.037364 
                 0.015208 
                 −0.48906 
                 KLRC3 
               
               
                 AJ000673 
                 0.047678 
                 0.037364 
                 0.009021 
                 −0.38103 
                 KLRD1 
               
               
                 AB002450 
                 0.047678 
                 0.037364 
                 0.003391 
                 −0.37426 
                 LOC51014 
               
               
                 U68385 
                 0.047678 
                 0.037364 
                 0.007651 
                 −0.16327 
                 MEIS3 
               
               
                 AI688516 
                 0.047678 
                 0.037364 
                 0.017859 
                 −0.15146 
                 NDUFA2 
               
               
                 W28770 
                 0.047678 
                 0.037364 
                 0.005269 
                 −0.16121 
                 NP25 
               
               
                 L41827 
                 0.047678 
                 0.037364 
                 0.011308 
                 0.139896 
                 NRG1 
               
               
                 X84373 
                 0.047678 
                 0.037364 
                 0.00725 
                 0.77533 
                 NRIP1 
               
               
                 M25897 
                 0.047678 
                 0.037364 
                 0.025747 
                 −0.41462 
                 PF4 
               
               
                 U50062 
                 0.047678 
                 0.037364 
                 0.018154 
                 0.19401 
                 RIPK1 
               
               
                 AJ011785 
                 0.047678 
                 0.037364 
                 0.017907 
                 −0.07616 
                 SIX6 
               
               
                 X70683 
                 0.047678 
                 0.037364 
                 0.0155 
                 −0.10219 
                 SOX4 
               
               
                 AL035699 
                 0.047678 
                 0.037364 
                 0.006561 
                 −0.15185 
                 TBPL1 
               
               
                 D15050 
                 0.047678 
                 0.037364 
                 0.016133 
                 0.990791 
                 TCF8 
               
               
                 AF017146 
                 0.047678 
                 0.037364 
                 0.002975 
                 −0.20652 
                 TOP3B 
               
               
                 U54996 
                 0.047678 
                 0.037364 
                 0.00691 
                 −0.17359 
                 ZW10 
               
               
                 HG4234-HT4504 
                 0.047678 
                 0.037364 
                 0.003258 
                 −0.13985 
               
               
                 X04500 
                 0.047678 
                 0.058634 
                 0.02228 
                 0.857952 
                 IL1B 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE IV 
               
             
            
               
                   
               
               
                   
               
               
                 Differential Gene Expression in MOG-reactive T-cells-MS vs. 
               
               
                 Healthy 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                 Fold 
                 Pvalue 
               
               
                 Identifier 
                 Symbol 
                 Name 
                 Function 
                 Change 
                 t-test 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Up 
                   
                   
                   
                   
                   
               
               
                 regulated 
               
               
                 M35878 
                 IGFBP3 
                 insulin-like growth 
                 modulate IGF activity 
                 5.8 
                 0.03 
               
               
                   
                   
                 factor binding protein 3 
               
               
                 AB002318 
                 KIAA0320 
                 KIAA0320 protein 
                   
                 2.4 
                 0.05 
               
               
                 AF024710 
                 VEGF 
                 vascular endothelial 
                 endothelial cell 
                 2.3 
                 0.02 
               
               
                   
                   
                 growth factor 
                 proliferation 
               
               
                 AA628946 
                 KHSRP 
                 KH-type splicing 
                 mRNA processing 
                 2.2 
                 0.01 
               
               
                   
                   
                 regulatory protein 
               
               
                 L42374 
                 PPP2R5B 
                 protein phosphatase 2, 
                 protein phosphatase 
                 2.1 
                 0.05 
               
               
                   
                   
                 regulatory subunit B 
               
               
                 U54644 
                 TUB 
                 tubby (mouse) 
                 may be a 
                 1.8 
                 0.01 
               
               
                   
                   
                 homolog 
                 transcription factor 
               
               
                 AB023167 
                 KIAA0950 
                 lifeguard 
                 Apoptosis 
                 1.8 
                 0.006 
               
               
                 X62654 
                 CD63 
                 CD63 antigen 
                 growth regulation 
                 1.8 
                 0.03 
               
               
                   
                   
                 (melanoma 1 antigen) 
               
               
                 H98552 
                   
                 cDNA 
                   
                 1.8 
                 0.01 
               
               
                   
                   
                 DKFZp586I0523 
               
               
                 AL050395 
                 MOF 
                 member of MYST 
                 histone acetyl 
                 1.7 
                 0.03 
               
               
                   
                   
                 acetyl transferases 
                 transferases 
               
               
                 L27213 
                 SLC4A3 
                 solute carrier family 4, 
                 inorganic anion 
                 1.7 
                 0.01 
               
               
                   
                   
                 anion exchange 3 
                 exchanger 
               
               
                 AF014837 
                 M6A 
                 putative 
                 Transcription factor 
                 1.6 
                 0.05 
               
               
                   
                   
                 methyltransferase 
               
               
                 AB014537 
                 KIAA0637 
                 KIAA0637 gene 
                 Apoptosis 
                 1.5 
                 0.003 
               
               
                   
                   
                 product 
               
               
                 D13969 
                 ZNF144 
                 zinc finger protein 144 
                 DNA-Binding protein 
                 1.5 
                 0.04 
               
               
                   
                   
                 (Mel-18) 
               
               
                 AJ012590 
                 H6PD 
                 hexose-6-phosphate 
                 Oxidoreductase 
                 1.5 
                 0.04 
               
               
                   
                   
                 dehydrogenase 
               
               
                 M13995 
                 BCL2 
                 B-cell CLL/lymphoma 2 
                 Apoptosis 
                 1.5 
                 0.03 
               
               
                 AI760801 
                   
                 chromosome 19, 
                   
                 1.5 
                 0.009 
               
               
                   
                   
                 cosmid R31180 
               
               
                 AI660963 
                 MAP3K12 
                 mitogen-activated 
                 Transferase 
                 1.5 
                 0.02 
               
               
                   
                   
                 protein 3 kinase 12 
                 cytoplasmic 
               
               
                 Down 
               
               
                 regulated 
               
               
                 D45248 
                 PSME2 
                 proteasome activator 
                 Protein degradation 
                 −1.5 
                 0.04 
               
               
                   
                   
                 subunit 2 (PA28 beta) 
               
               
                 W28612 
                   
                 ESTs 
                   
                 −1.5 
                 0.02 
               
               
                 Z46389 
                 VASP 
                 vasodilator-stimulated 
                 Signal transduction 
                 −1.6 
                 0.02 
               
               
                   
                   
                 phosphoprotein 
               
               
                 AA152202 
                 FLJ14639 
                 hypothetical protein 
                   
                 −1.6 
                 0.02 
               
               
                   
                   
                 FLJ14639 
               
               
                 AF080561 
                 RBM14 
                 RNA binding motif 
                 RNA binding protein 
                 −1.7 
                 0.03 
               
               
                   
                   
                 protein 14 
               
               
                 D50922 
                 KIAA0132 
                 Kelch-like ECH- 
                 ECH-associated 
                 −1.7 
                 0.03 
               
               
                   
                   
                 associated protein 1 
                 protein 1 
               
               
                 AF025441 
                 OIP5 
                 Opa-interacting protein 5 
                   
                 −1.8 
                 0.04 
               
               
                 AF080227 
                 EED 
                 embryonic ectoderm 
                 transcriptional 
                 −1.8 
                 0.04 
               
               
                   
                   
                 development 
                 repressor 
               
               
                 D87957 
                 RQCD1 
                 required for cell 
                 sex differentiation 
                 −1.9 
                 0.03 
               
               
                   
                   
                 differentiation 
               
               
                 X61498 
                 NFKB2 
                 nuclear factor of kappa 
                 expression of 
                 −1.9 
                 0.05 
               
               
                   
                   
                 light polypeptide 
                 inflammatory genes 
               
               
                   
                   
                 Bcells 
               
               
                 X52425 
                 IL4R 
                 interleukin 4 receptor 
                 receptor signalling 
                 −2 
                 0.04 
               
               
                   
                   
                   
                 protein 
               
               
                 L08069 
                 DNAJA1 
                 DnaJ (Hsp40) 
                 protein folding and 
                 −2 
                 0.04 
               
               
                   
                   
                 homolog, subfamily A, 
                 transport 
               
               
                   
                   
                 member 1 
               
               
                 AF071504 
                 STX11 
                 syntaxin 11 
                 protein transport 
                 −2.1 
                 0.03 
               
               
                 M11717 
                 HSPA1A 
                 heat shock 70 kD 
                 heat shock response 
                 −2.2 
                 0.03 
               
               
                   
                   
                 protein 1A 
               
               
                 M59830 
                 HSPA1B 
                 heat shock 70 kD 
                 heat shock response 
                 −2.2 
                 0.03 
               
               
                   
                   
                 protein 1B 
               
               
                 M16441 
                 TNF 
                 Human tumor necrosis 
                 Inflammatory 
                 −2.3 
                 0.05 
               
               
                   
                   
                 factor 
                 response 
               
               
                 D89077 
                 SLA 
                 Src-like-adapter 
                   
                 −2.4 
                 0.05 
               
               
                 U77949 
                 CDC6 
                 cell division cycle 6, S. cerevisiae 
                 DNA replication 
                 −2.5 
                 0.02 
               
               
                   
                   
                 homolog 
                 checkpoint 
               
               
                 D38549 
                 KIAA0068 
                 KIAA0068 protein 
                   
                 −2.5 
                 0.01 
               
               
                 L23959 
                 TFDP1 
                 transcription factor Dp-1 
                 cycle progression G1 
                 −2.5 
                 0.01 
               
               
                   
                   
                   
                 to S-phase 
               
               
                 L78833 
                 BRCA1 
                 Breast cancer 
                   
                 −2.7 
                 0.04 
               
               
                   
                   
                 susceptibility gene 
               
               
                 M63193 
                 ECGF1 
                 endothelial cell growth 
                 stimulates 
                 −2.8 
                 0.01 
               
               
                   
                   
                 factor 1 
                 angiogenesis 
               
               
                 AF035625 
                 STK11 
                 serine/threonine kinase 
                 Peutz-Jeghers 
                 −2.9 
                 0.04 
               
               
                   
                   
                 11 
                 syndrome 
               
               
                 J04130 
                 SCYA4 
                 small inducible 
                 Cell-to-cell signalling 
                 −2.9 
                 0.05 
               
               
                   
                   
                 cytokine A4 
               
               
                 X93086 
                 BLVRA 
                 biliverdin reductase A 
                 biliverdin reductase 
                 −4 
                 0.03 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE V 
               
             
            
               
                   
               
               
                   
               
               
                 Differential Gene Expression in Probable MS vs. Healthy 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                 t-Test 
                 Log Fold 
                   
               
               
                 Identification 
                 TNOM PValue 
                 Info PValue 
                 PValue 
                 Change 
                 Gene Symbol 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 NM_018049.1 
                 0.000233 
                 0.000233 
                 2.46E−05 
                 0.438337 
                 FLJ10297 
               
               
                 NM_005886.1 
                 0.000233 
                 0.000233 
                 0.000553 
                 0.35972 
                 KATNB1 
               
               
                 NM_000161.1 
                 0.000233 
                 0.000233 
                 0.000297 
                 −0.48848 
                 GCH1 
               
               
                 NM_001539.1 
                 0.000233 
                 0.000233 
                 0.000144 
                 −0.58017 
                 DNAJA1 
               
               
                 AF349571.1 
                 0.004202 
                 0.004202 
                 0.000274 
                 1.78925 
                 HBA1 
               
               
                 M25079.1 
                 0.004202 
                 0.004202 
                 0.000247 
                 1.59503 
                 HBB 
               
               
                 V00489 
                 0.004202 
                 0.004202 
                 0.000268 
                 1.54947 
               
               
                 BC005931.1 
                 0.004202 
                 0.004202 
                 0.000296 
                 1.48707 
                 HBA2 
               
               
                 T50399 
                 0.004202 
                 0.004202 
                 0.000275 
                 1.43533 
                 HBA2 
               
               
                 NM_024567.1 
                 0.004202 
                 0.004202 
                 0.002206 
                 1.42146 
                 FLJ21616 
               
               
                 AF105974.1 
                 0.004202 
                 0.004202 
                 0.001086 
                 1.3896 
                 HBA1 
               
               
                 NM_000558.2 
                 0.004202 
                 0.004202 
                 0.000707 
                 1.3348 
                 HBA1 
               
               
                 AI133353 
                 0.004202 
                 0.004202 
                 0.000897 
                 1.29746 
                 HBG2 
               
               
                 AF059180 
                 0.004202 
                 0.004202 
                 0.000309 
                 1.29355 
               
               
                 AF349114.1 
                 0.004202 
                 0.004202 
                 0.000163 
                 1.27511 
                 HBB 
               
               
                 BE547674 
                 0.004202 
                 0.004202 
                 0.002947 
                 0.636619 
               
               
                 NM_012452.1 
                 0.004202 
                 0.004202 
                 0.000541 
                 0.570818 
                 TNFRSF13B 
               
               
                 AA314406 
                 0.004202 
                 0.001401 
                 0.002013 
                 0.520631 
                 TRAP95 
               
               
                 NM_015909.1 
                 0.004202 
                 0.001401 
                 0.000398 
                 0.501733 
                 NAG 
               
               
                 NM_006868.1 
                 0.004202 
                 0.004202 
                 0.002711 
                 0.49862 
                 RAB31 
               
               
                 BC000305.1 
                 0.004202 
                 0.004202 
                 0.006921 
                 0.475733 
                 CASP6 
               
               
                 L77566 
                 0.004202 
                 0.001401 
                 0.00033 
                 0.446293 
                 DGSI 
               
               
                 BF971416 
                 0.004202 
                 0.004202 
                 0.002405 
                 0.410742 
                 DKFZP586N0721 
               
               
                 BE879367 
                 0.004202 
                 0.004202 
                 0.00056 
                 0.382484 
                 AKAP2 
               
               
                 NM_001640.2 
                 0.004202 
                 0.001401 
                 0.004091 
                 0.36631 
                 APEH 
               
               
                 BC001808.1 
                 0.004202 
                 0.004202 
                 0.012997 
                 0.347043 
                 NM23-H6 
               
               
                 AL049539 
                 0.004202 
                 0.004202 
                 0.010738 
                 0.2822 
                 KIAA0255 
               
               
                 BC000580.1 
                 0.004202 
                 0.001401 
                 0.014166 
                 0.270658 
                 PH-4 
               
               
                 NM_012151.2 
                 0.004202 
                 0.001401 
                 0.000685 
                 0.267664 
                 F8A 
               
               
                 BC004423.1 
                 0.004202 
                 0.004202 
                 0.012194 
                 0.249144 
                 TNRC5 
               
               
                 NM_004890.1 
                 0.004202 
                 0.001401 
                 0.010332 
                 0.134439 
                 SPAG7 
               
               
                 AB029040 
                 0.004202 
                 0.004202 
                 0.010819 
                 −0.14172 
                 KIAA1117 
               
               
                 NM_025160.1 
                 0.004202 
                 0.001401 
                 0.004986 
                 −0.21141 
                 FLJ21016 
               
               
                 AW162015 
                 0.004202 
                 0.004202 
                 0.301224 
                 −0.24766 
                 ZNF143 
               
               
                 NM_005574.2 
                 0.004202 
                 0.004202 
                 0.107595 
                 −0.24939 
                 LMO2 
               
               
                 NM_014670.1 
                 0.004202 
                 0.004202 
                 0.025534 
                 −0.27225 
                 BZW1 
               
               
                 AL117643.1 
                 0.004202 
                 0.004202 
                 0.046495 
                 −0.27766 
               
               
                 AA628948 
                 0.004202 
                 0.001401 
                 0.000319 
                 −0.28951 
                 ADSS 
               
               
                 AF251062.1 
                 0.004202 
                 0.001401 
                 0.000435 
                 −0.30924 
                 LOC84549 
               
               
                 AL564683 
                 0.004202 
                 0.004202 
                 0.018258 
                 −0.44633 
                 CEBPB 
               
               
                 NM_014999.1 
                 0.004202 
                 0.004202 
                 0.001021 
                 −0.47304 
                 RAB21 
               
               
                 NM_017723.1 
                 0.004202 
                 0.004202 
                 0.02759 
                 −0.49548 
                 FLJ20245 
               
               
                 NM_003264.1 
                 0.004202 
                 0.004202 
                 0.002592 
                 −0.49551 
                 TLR2 
               
               
                 AF062347.1 
                 0.004202 
                 0.004202 
                 0.00529 
                 −0.51432 
                 ZNF216 
               
               
                 NM_004556.1 
                 0.004202 
                 0.004202 
                 0.001134 
                 −0.53489 
                 NFKBIE 
               
               
                 U92014.1 
                 0.004202 
                 0.004202 
                 0.003064 
                 −0.59511 
               
               
                 NM_014778.1 
                 0.004202 
                 0.004202 
                 0.001106 
                 −0.65156 
                 KIAA0410 
               
               
                 NM_015384.1 
                 0.004202 
                 0.004202 
                 0.002943 
                 −0.68193 
                 IDN3 
               
               
                 AK022513.1 
                 0.004202 
                 0.004202 
                 0.001326 
                 −0.68416 
                 DUSP10 
               
               
                 NM_003246.1 
                 0.004202 
                 0.001401 
                 0.000162 
                 −1.44745 
                 THBS1 
               
               
                 AI812030 
                 0.004202 
                 0.001401 
                 7.42E−05 
                 −1.51098 
                 THBS1 
               
               
                 NM_000559.1 
                 0.035714 
                 0.035247 
                 0.006202 
                 1.93991 
                 HBG1 
               
               
                 NM_000184.1 
                 0.035714 
                 0.04225 
                 0.009164 
                 1.67513 
                 HBG2 
               
               
                 NM_005564.1 
                 0.035714 
                 0.04225 
                 0.010814 
                 1.03322 
                 LCN2 
               
               
                 AF274863.1 
                 0.035714 
                 0.00747 
                 0.007719 
                 0.952868 
                 SEC31B-1 
               
               
                 NM_002288.2 
                 0.035714 
                 0.015406 
                 0.010689 
                 0.834313 
                 LAIR2 
               
               
                 M87789.1 
                 0.035714 
                 0.04225 
                 0.058518 
                 0.79032 
                 IGHG3 
               
               
                 NM_005764.1 
                 0.035714 
                 0.04225 
                 0.053679 
                 0.789147 
                 DD96 
               
               
                 AK000168.1 
                 0.035714 
                 0.04225 
                 0.038176 
                 0.763766 
                 KIAA1919 
               
               
                 NM_020037.1 
                 0.035714 
                 0.035247 
                 0.061379 
                 0.746143 
                 ABCC3 
               
               
                 AF103529.1 
                 0.035714 
                 0.035247 
                 0.015284 
                 0.736268 
               
               
                 AV698647 
                 0.035714 
                 0.035247 
                 0.017411 
                 0.616137 
                 IGLJ3 
               
               
                 AI357539 
                 0.035714 
                 0.04225 
                 0.00558 
                 0.601843 
                 MGC4126 
               
               
                 NM_015935.1 
                 0.035714 
                 0.035247 
                 0.021683 
                 0.593818 
                 CGI-01 
               
               
                 D38535 
                 0.035714 
                 0.04225 
                 0.016025 
                 0.571168 
                 ITIH4 
               
               
                 AA723370 
                 0.035714 
                 0.04225 
                 0.039917 
                 0.570325 
                 LOC51011 
               
               
                 AF227968.1 
                 0.035714 
                 0.00747 
                 0.005308 
                 0.566516 
                 SH2B 
               
               
                 X12530.1 
                 0.035714 
                 0.04225 
                 0.056335 
                 0.559172 
                 MS4A1 
               
               
                 AI348935 
                 0.035714 
                 0.035247 
                 0.014129 
                 0.546773 
                 CALR 
               
               
                 NM_003422.1 
                 0.035714 
                 0.04225 
                 0.006737 
                 0.536815 
                 ZNF42 
               
               
                 NM_015559.1 
                 0.035714 
                 0.04225 
                 0.028795 
                 0.536316 
                 SETBP1 
               
               
                 NM_013378.1 
                 0.035714 
                 0.035247 
                 0.005191 
                 0.532564 
                 VPREB3 
               
               
                 NM_004912.1 
                 0.035714 
                 0.015406 
                 0.003037 
                 0.52082 
                 CCM1 
               
               
                 NM_006230.1 
                 0.035714 
                 0.015406 
                 0.007471 
                 0.517979 
                 POLD2 
               
               
                 NM_006235.1 
                 0.035714 
                 0.035247 
                 0.021726 
                 0.515263 
                 POU2AF1 
               
               
                 AL037557 
                 0.035714 
                 0.00747 
                 0.002786 
                 0.511724 
                 POLR2I 
               
               
                 NM_014703.1 
                 0.035714 
                 0.00747 
                 0.006709 
                 0.4938 
                 KIAA0800 
               
               
                 NM_015670.1 
                 0.035714 
                 0.035247 
                 0.045708 
                 0.464156 
                 SENP3 
               
               
                 AA643304 
                 0.035714 
                 0.015406 
                 0.004712 
                 0.459694 
               
               
                 AI948503 
                 0.035714 
                 0.04225 
                 0.017964 
                 0.45625 
                 ABCC4 
               
               
                 BC002807.1 
                 0.035714 
                 0.04225 
                 0.100759 
                 0.455683 
                 MS4A1 
               
               
                 AF123539.1 
                 0.035714 
                 0.035247 
                 0.028286 
                 0.454603 
                 HTCD37 
               
               
                 AA149644 
                 0.035714 
                 0.00747 
                 0.02413 
                 0.450082 
                 JAM3 
               
               
                 BC000585.1 
                 0.035714 
                 0.04225 
                 0.033113 
                 0.44368 
                 SLC21A11 
               
               
                 AB044806.1 
                 0.035714 
                 0.04225 
                 0.007766 
                 0.433985 
                 KCNH2 
               
               
                 U37025 
                 0.035714 
                 0.035247 
                 0.046971 
                 0.427213 
                 SULT1A1 
               
               
                 NM_020166.2 
                 0.035714 
                 0.035247 
                 0.006318 
                 0.423798 
                 MCCC1 
               
               
                 NM_002876.1 
                 0.035714 
                 0.035247 
                 0.026644 
                 0.414867 
                 RAD51C 
               
               
                 NM_002387.1 
                 0.035714 
                 0.035247 
                 0.01092 
                 0.409481 
                 MCC 
               
               
                 NM_005816.1 
                 0.035714 
                 0.04225 
                 0.103051 
                 0.407348 
                 TACTILE 
               
               
                 H95263 
                 0.035714 
                 0.035247 
                 0.069113 
                 0.406766 
               
               
                 NM_003146.1 
                 0.035714 
                 0.035247 
                 0.003146 
                 0.405309 
                 SSRP1 
               
               
                 NM_003550.1 
                 0.035714 
                 0.035247 
                 0.054105 
                 0.403851 
                 MAD1L1 
               
               
                 AK022494.1 
                 0.035714 
                 0.00747 
                 0.001189 
                 0.397073 
                 RAB3GAP 
               
               
                 NM_006400.2 
                 0.035714 
                 0.035247 
                 0.021072 
                 0.396297 
                 DCTN2 
               
               
                 NM_006012.1 
                 0.035714 
                 0.035247 
                 0.015241 
                 0.394779 
                 CLPP 
               
               
                 NM_014921.1 
                 0.035714 
                 0.035247 
                 0.014463 
                 0.394308 
                 LEC2 
               
               
                 NM_025056.1 
                 0.035714 
                 0.00747 
                 0.01912 
                 0.393739 
                 FLJ23185 
               
               
                 NM_003573.1 
                 0.035714 
                 0.04225 
                 0.026053 
                 0.393337 
                 LTBP4 
               
               
                 NM_000132.2 
                 0.035714 
                 0.035247 
                 0.005292 
                 0.392442 
                 F8 
               
               
                 AF031824.1 
                 0.035714 
                 0.035247 
                 0.190243 
                 0.389129 
                 CST7 
               
               
                 NM_001841.1 
                 0.035714 
                 0.035247 
                 0.07115 
                 0.387067 
                 CNR2 
               
               
                 NM_018391.1 
                 0.035714 
                 0.035247 
                 0.138584 
                 0.386982 
                 FLJ23277 
               
               
                 U79248.1 
                 0.035714 
                 0.00747 
                 0.007475 
                 0.386419 
               
               
                 NM_024332.1 
                 0.035714 
                 0.04225 
                 0.039154 
                 0.386198 
                 C6.1A 
               
               
                 BF510692 
                 0.035714 
                 0.04225 
                 0.046782 
                 0.385324 
                 PAX5 
               
               
                 AA243774 
                 0.035714 
                 0.035247 
                 0.050456 
                 0.381631 
                 MMP24 
               
               
                 AL121964 
                 0.035714 
                 0.035247 
                 0.107681 
                 0.373759 
                 MAP3K7 
               
               
                 L25275.1 
                 0.035714 
                 0.035247 
                 0.020684 
                 0.372971 
                 SULT1A3 
               
               
                 AB018289.1 
                 0.035714 
                 0.035247 
                 0.002286 
                 0.37263 
                 KIAA0746 
               
               
                 NM_000294.1 
                 0.035714 
                 0.035247 
                 0.011432 
                 0.367693 
                 PHKG2 
               
               
                 BC001906.1 
                 0.035714 
                 0.035247 
                 0.107947 
                 0.366899 
                 MTX1 
               
               
                 NM_000651.1 
                 0.035714 
                 0.04225 
                 0.047953 
                 0.365471 
                 CR1 
               
               
                 NM_001667.1 
                 0.035714 
                 0.00747 
                 0.009661 
                 0.362105 
                 ARL2 
               
               
                 AI133727 
                 0.035714 
                 0.00747 
                 0.018354 
                 0.358884 
                 ZAP 
               
               
                 BC002873.1 
                 0.035714 
                 0.035247 
                 0.048711 
                 0.358052 
                 DKFZP564J0123 
               
               
                 NM_004178.2 
                 0.035714 
                 0.035247 
                 0.007313 
                 0.356459 
                 TARBP2 
               
               
                 BG532929 
                 0.035714 
                 0.035247 
                 0.037215 
                 0.356254 
                 SSB 
               
               
                 NM_018094.1 
                 0.035714 
                 0.035247 
                 0.014302 
                 0.351314 
                 GSPT2 
               
               
                 AC004531 
                 0.035714 
                 0.00747 
                 0.01714 
                 0.350445 
                 DDX28 
               
               
                 NM_001981.1 
                 0.035714 
                 0.035247 
                 0.010776 
                 0.347051 
                 EPS15 
               
               
                 AB020689.1 
                 0.035714 
                 0.035247 
                 0.024594 
                 0.346253 
                 KIAA0882 
               
               
                 NM_001055.1 
                 0.035714 
                 0.035247 
                 0.056416 
                 0.344937 
                 SULT1A1 
               
               
                 NM_022067.1 
                 0.035714 
                 0.035247 
                 0.001332 
                 0.337713 
                 FLJ12707 
               
               
                 NM_000195.1 
                 0.035714 
                 0.00747 
                 0.014156 
                 0.3312 
                 HPS1 
               
               
                 NM_022914.1 
                 0.035714 
                 0.00747 
                 0.167735 
                 0.331082 
                 24432 
               
               
                 NM_003627.1 
                 0.035714 
                 0.035247 
                 0.062759 
                 0.330371 
                 POV1 
               
               
                 NM_022060.1 
                 0.035714 
                 0.035247 
                 0.010717 
                 0.328122 
                 FLJ12816 
               
               
                 BF446180 
                 0.035714 
                 0.035247 
                 0.02537 
                 0.326347 
                 PDCD2 
               
               
                 U28169.1 
                 0.035714 
                 0.035247 
                 0.0891 
                 0.326218 
                 SULT1A2 
               
               
                 AF316873.1 
                 0.035714 
                 0.035247 
                 0.022727 
                 0.3257 
                 PINK1 
               
               
                 NM_017615.1 
                 0.035714 
                 0.035247 
                 0.087717 
                 0.325056 
                 FLJ20003 
               
               
                 NM_015853.1 
                 0.035714 
                 0.035247 
                 0.021537 
                 0.321089 
                 LOC51035 
               
               
                 NM_018449.1 
                 0.035714 
                 0.035247 
                 0.01461 
                 0.318475 
                 UBAP2 
               
               
                 NM_007056.1 
                 0.035714 
                 0.035247 
                 0.013827 
                 0.318086 
                 SWAP2 
               
               
                 AV702994 
                 0.035714 
                 0.035247 
                 0.010766 
                 0.316138 
                 LOC51668 
               
               
                 AK021884.1 
                 0.035714 
                 0.04225 
                 0.016862 
                 0.315879 
                 NPEPPS 
               
               
                 U64898.1 
                 0.035714 
                 0.035247 
                 0.012705 
                 0.309446 
                 NRD1 
               
               
                 AI431902 
                 0.035714 
                 0.035247 
                 0.026163 
                 0.307321 
                 FLJ13491 
               
               
                 NM_003689.1 
                 0.035714 
                 0.04225 
                 0.03366 
                 0.306281 
                 AKR7A2 
               
               
                 BE791629 
                 0.035714 
                 0.00747 
                 0.039522 
                 0.304821 
                 CGTHBA 
               
               
                 NM_016194.1 
                 0.035714 
                 0.035247 
                 0.060249 
                 0.303474 
                 GNB5 
               
               
                 NM_014965.1 
                 0.035714 
                 0.035247 
                 0.013547 
                 0.298042 
                 KIAA1042 
               
               
                 NM_003363.1 
                 0.035714 
                 0.035247 
                 0.018393 
                 0.295239 
                 USP4 
               
               
                 U88964 
                 0.035714 
                 0.035247 
                 0.019349 
                 0.294427 
                 ISG20 
               
               
                 BC001782.1 
                 0.035714 
                 0.035247 
                 0.059026 
                 0.293156 
                 GAS2L1 
               
               
                 BC004361.1 
                 0.035714 
                 0.04225 
                 0.084538 
                 0.292509 
                 PSCD2 
               
               
                 NM_017840.1 
                 0.035714 
                 0.035247 
                 0.003929 
                 0.290472 
                 MRPL16 
               
               
                 NM_006321.1 
                 0.035714 
                 0.015406 
                 0.006688 
                 0.288723 
                 ARIH2 
               
               
                 AI341234 
                 0.035714 
                 0.035247 
                 0.007356 
                 0.284699 
                 CORO1B 
               
               
                 N20923 
                 0.035714 
                 0.035247 
                 0.020271 
                 0.280552 
                 FYN 
               
               
                 L42531.1 
                 0.035714 
                 0.035247 
                 0.008554 
                 0.280023 
               
               
                 AK000818.1 
                 0.035714 
                 0.035247 
                 0.02226 
                 0.277695 
                 FLJ20811 
               
               
                 NM_000633.1 
                 0.035714 
                 0.035247 
                 0.044639 
                 0.276897 
                 BCL2 
               
               
                 BE551347 
                 0.035714 
                 0.035247 
                 0.209003 
                 0.276406 
                 FLJ13052 
               
               
                 AK000161.1 
                 0.035714 
                 0.04225 
                 0.016752 
                 0.276103 
                 FLJ20154 
               
               
                 AI798908 
                 0.035714 
                 0.04225 
                 0.015969 
                 0.274921 
                 KIAA0226 
               
               
                 NM_005111.1 
                 0.035714 
                 0.035247 
                 0.01405 
                 0.273732 
                 CRYZL1 
               
               
                 NM_024551.1 
                 0.035714 
                 0.035247 
                 0.00372 
                 0.272684 
                 FLJ21432 
               
               
                 BC006214.1 
                 0.035714 
                 0.00747 
                 0.006244 
                 0.268704 
                 IRO039700 
               
               
                 AI123527 
                 0.035714 
                 0.04225 
                 0.105392 
                 0.268349 
                 KIAA0092 
               
               
                 NM_004379.1 
                 0.035714 
                 0.035247 
                 0.047229 
                 0.267796 
                 CREB1 
               
               
                 AA643304 
                 0.035714 
                 0.035247 
                 0.039678 
                 0.258201 
               
               
                 NM_013417.1 
                 0.035714 
                 0.035247 
                 0.047087 
                 0.257738 
                 IARS 
               
               
                 AK025432.1 
                 0.035714 
                 0.035247 
                 0.051871 
                 0.257456 
                 KIAA0564 
               
               
                 AB028960 
                 0.035714 
                 0.04225 
                 0.040942 
                 0.254827 
                 KIAA1037 
               
               
                 NM_000048.1 
                 0.035714 
                 0.04225 
                 0.038931 
                 0.254447 
                 ASL 
               
               
                 NM_002808.1 
                 0.035714 
                 0.035247 
                 0.023966 
                 0.250129 
                 PSMD2 
               
               
                 NM_001054.1 
                 0.035714 
                 0.035247 
                 0.062598 
                 0.248696 
                 SULT1A2 
               
               
                 NM_005428.2 
                 0.035714 
                 0.035247 
                 0.007185 
                 0.248439 
                 VAV1 
               
               
                 NM_022758.1 
                 0.035714 
                 0.04225 
                 0.011489 
                 0.246401 
                 FLJ22195 
               
               
                 AY009128.1 
                 0.035714 
                 0.035247 
                 0.084938 
                 0.246257 
                 NIFU 
               
               
                 AB017004.1 
                 0.035714 
                 0.035247 
                 0.079567 
                 0.244954 
                 PMS2L8 
               
               
                 NM_000249.1 
                 0.035714 
                 0.04225 
                 0.021274 
                 0.243441 
                 MLH1 
               
               
                 U51007.1 
                 0.035714 
                 0.035247 
                 0.042753 
                 0.242223 
               
               
                 BC002640.1 
                 0.035714 
                 0.035247 
                 0.074751 
                 0.240603 
               
               
                 NM_016284.1 
                 0.035714 
                 0.00747 
                 0.001929 
                 0.240076 
                 KIAA1007 
               
               
                 NM_002414.1 
                 0.035714 
                 0.035247 
                 0.063998 
                 0.239013 
                 MIC2 
               
               
                 BC000212.1 
                 0.035714 
                 0.035247 
                 0.021052 
                 0.237577 
                 GTF3C2 
               
               
                 NM_004398.2 
                 0.035714 
                 0.035247 
                 0.040656 
                 0.235252 
                 DDX10 
               
               
                 NM_024713.1 
                 0.035714 
                 0.035247 
                 0.048887 
                 0.234927 
                 FLJ22557 
               
               
                 NM_002810.1 
                 0.035714 
                 0.035247 
                 0.038558 
                 0.234593 
                 PSMD4 
               
               
                 NM_030580.1 
                 0.035714 
                 0.035247 
                 0.031263 
                 0.233466 
                 MGC10520 
               
               
                 AB007896.1 
                 0.035714 
                 0.035247 
                 0.211816 
                 0.231563 
                 KIAA0436 
               
               
                 NM_003954.1 
                 0.035714 
                 0.04225 
                 0.051916 
                 0.230862 
                 MAP3K14 
               
               
                 NM_025207.1 
                 0.035714 
                 0.035247 
                 0.020823 
                 0.230015 
                 PP591 
               
               
                 NM_016323.1 
                 0.035714 
                 0.035247 
                 0.051393 
                 0.228764 
                 LOC51191 
               
               
                 NM_016069.1 
                 0.035714 
                 0.04225 
                 0.132766 
                 0.223618 
                 Magmas 
               
               
                 NM_013349.1 
                 0.035714 
                 0.035247 
                 0.028748 
                 0.223073 
                 SPUF 
               
               
                 NM_000884.1 
                 0.035714 
                 0.035247 
                 0.064347 
                 0.222421 
                 IMPDH2 
               
               
                 BG167570 
                 0.035714 
                 0.04225 
                 0.108243 
                 0.219652 
                 DKFZp762N1910 
               
               
                 NM_004551.1 
                 0.035714 
                 0.00747 
                 0.06025 
                 0.217427 
                 NDUFS3 
               
               
                 BG231932 
                 0.035714 
                 0.04225 
                 0.079649 
                 0.210447 
                 CLN2 
               
               
                 NM_017851.1 
                 0.035714 
                 0.035247 
                 0.036308 
                 0.209956 
                 FLJ20509 
               
               
                 NM_006519.1 
                 0.035714 
                 0.035247 
                 0.032991 
                 0.202387 
                 TCTEL1 
               
               
                 AF032900.1 
                 0.035714 
                 0.035247 
                 0.174549 
                 0.200739 
                 COQ7 
               
               
                 AL535380 
                 0.035714 
                 0.035247 
                 0.265205 
                 0.198073 
                 BTG1 
               
               
                 AW118862 
                 0.035714 
                 0.035247 
                 0.02173 
                 0.193753 
                 RREB1 
               
               
                 NM_000382.1 
                 0.035714 
                 0.035247 
                 0.27948 
                 0.193509 
                 ALDH3A2 
               
               
                 NM_024419.1 
                 0.035714 
                 0.035247 
                 0.164883 
                 0.190623 
                 PGS1 
               
               
                 NM_003904.1 
                 0.035714 
                 0.035247 
                 0.245676 
                 0.190422 
                 ZNF259 
               
               
                 AI928526 
                 0.035714 
                 0.00747 
                 0.036861 
                 0.185624 
                 JTV1 
               
               
                 NM_024581.1 
                 0.035714 
                 0.035247 
                 0.230867 
                 0.185323 
                 FLJ13942 
               
               
                 AF085357.1 
                 0.035714 
                 0.035247 
                 0.110175 
                 0.184965 
                 FLOT1 
               
               
                 NM_004475.1 
                 0.035714 
                 0.035247 
                 0.072642 
                 0.180483 
                 FLOT2 
               
               
                 AF334103.1 
                 0.035714 
                 0.00747 
                 0.009664 
                 0.17511 
                 GU2 
               
               
                 NM_017829.1 
                 0.035714 
                 0.035247 
                 0.110207 
                 0.174515 
                 CECR5 
               
               
                 NM_004214.3 
                 0.035714 
                 0.04225 
                 0.016835 
                 0.157902 
                 FIBP 
               
               
                 NM_017704.1 
                 0.035714 
                 0.04225 
                 0.16159 
                 0.157672 
                 FLJ20189 
               
               
                 NM_003592.1 
                 0.035714 
                 0.035247 
                 0.038652 
                 0.146241 
                 CUL1 
               
               
                 AI537887 
                 0.035714 
                 0.035247 
                 0.467375 
                 0.139355 
                 EPB72 
               
               
                 NM_023935.1 
                 0.035714 
                 0.035247 
                 0.049119 
                 0.125305 
                 C20orf116 
               
               
                 BG398414 
                 0.035714 
                 0.035247 
                 0.286856 
                 0.123085 
                 RPA1 
               
               
                 NM_016243.1 
                 0.035714 
                 0.035247 
                 0.279995 
                 0.121894 
                 LOC51706 
               
               
                 NM_012199.1 
                 0.035714 
                 0.035247 
                 0.093241 
                 0.118547 
                 EIF2C1 
               
               
                 AK024029.1 
                 0.035714 
                 0.04225 
                 0.450393 
                 0.11646 
                 MAP-1 
               
               
                 NM_004848.1 
                 0.035714 
                 0.035247 
                 0.486492 
                 0.113516 
                 ICB-1 
               
               
                 AF144638.1 
                 0.035714 
                 0.035247 
                 0.255571 
                 0.10089 
                 SGPL1 
               
               
                 D86062.1 
                 0.035714 
                 0.035247 
                 0.532398 
                 0.084417 
                 C21orf33 
               
               
                 NM_000655.2 
                 0.035714 
                 0.035247 
                 0.535745 
                 0.081167 
                 SELL 
               
               
                 NM_018643.1 
                 0.035714 
                 0.035247 
                 0.870775 
                 0.057399 
                 TREM1 
               
               
                 NM_018326.1 
                 0.035714 
                 0.035247 
                 0.929375 
                 0.035048 
                 HIMAP4 
               
               
                 NM_005371.2 
                 0.035714 
                 0.035247 
                 0.876737 
                 0.025127 
                 METTL1 
               
               
                 NM_007002.1 
                 0.035714 
                 0.035247 
                 0.911541 
                 0.010422 
                 ADRM1 
               
               
                 NM_004723.1 
                 0.035714 
                 0.035247 
                 0.975685 
                 −0.00562 
                 ARHGEF2 
               
               
                 U31501 
                 0.035714 
                 0.035247 
                 0.724549 
                 −0.0658 
                 FXR2 
               
               
                 NM_005338.3 
                 0.035714 
                 0.04225 
                 0.126911 
                 −0.0661 
                 HIP1 
               
               
                 AB006589.1 
                 0.035714 
                 0.035247 
                 0.00542 
                 −0.10655 
                 ESR2 
               
               
                 AA868754 
                 0.035714 
                 0.035247 
                 0.304519 
                 −0.10746 
                 KIAA0650 
               
               
                 AU144792 
                 0.035714 
                 0.035247 
                 0.008623 
                 −0.11362 
               
               
                 AF320999.1 
                 0.035714 
                 0.035247 
                 0.289096 
                 −0.11449 
                 RTN4 
               
               
                 NM_013229.1 
                 0.035714 
                 0.035247 
                 0.529181 
                 −0.13735 
                 APAF1 
               
               
                 NM_018690.1 
                 0.035714 
                 0.04225 
                 0.261146 
                 −0.14482 
                 APOB48R 
               
               
                 D42055.1 
                 0.035714 
                 0.04225 
                 0.007978 
                 −0.14841 
                 NEDD4 
               
               
                 BF968633 
                 0.035714 
                 0.035247 
                 0.135003 
                 −0.14873 
                 RNF4 
               
               
                 AK026678.1 
                 0.035714 
                 0.035247 
                 0.00833 
                 −0.15056 
                 STAG2 
               
               
                 NM_014671.1 
                 0.035714 
                 0.035247 
                 0.392979 
                 −0.15386 
                 KIAA0010 
               
               
                 NM_030979.1 
                 0.035714 
                 0.035247 
                 0.087494 
                 −0.15652 
                 PABPC3 
               
               
                 BG429214 
                 0.035714 
                 0.035247 
                 0.273519 
                 −0.15766 
               
               
                 NM_006892.1 
                 0.035714 
                 0.035247 
                 0.001922 
                 −0.15828 
                 DNMT3B 
               
               
                 NM_018975.1 
                 0.035714 
                 0.035247 
                 0.042202 
                 −0.16723 
                 RAP1 
               
               
                 AL137335.1 
                 0.035714 
                 0.035247 
                 0.306422 
                 −0.17292 
                 RANBP7 
               
               
                 NM_014016.1 
                 0.035714 
                 0.035247 
                 0.398036 
                 −0.17365 
                 SACM1L 
               
               
                 NM_012198.1 
                 0.035714 
                 0.035247 
                 0.391555 
                 −0.17556 
                 GCA 
               
               
                 NM_024586.1 
                 0.035714 
                 0.04225 
                 0.011965 
                 −0.19298 
                 OSBPL9 
               
               
                 N64643 
                 0.035714 
                 0.035247 
                 0.16498 
                 −0.19313 
                 KIAA0625 
               
               
                 NM_005951.1 
                 0.035714 
                 0.035247 
                 0.156965 
                 −0.1942 
                 MT1H 
               
               
                 NM_002264.1 
                 0.035714 
                 0.035247 
                 0.138195 
                 −0.1949 
               
               
                 AF182415.1 
                 0.035714 
                 0.04225 
                 0.325959 
                 −0.19495 
                 RBM8A 
               
               
                 BE674061 
                 0.035714 
                 0.035247 
                 0.015036 
                 −0.20133 
                 PIN4 
               
               
                 NM_004973.2 
                 0.035714 
                 0.00747 
                 0.103071 
                 −0.20162 
                 JMJ 
               
               
                 U58852.1 
                 0.035714 
                 0.035247 
                 0.510508 
                 −0.20606 
                 NPAT 
               
               
                 NM_005565.2 
                 0.035714 
                 0.035247 
                 0.037541 
                 −0.2105 
                 LCP2 
               
               
                 NM_004941.1 
                 0.035714 
                 0.035247 
                 0.229189 
                 −0.21215 
                 DDX8 
               
               
                 U02297.1 
                 0.035714 
                 0.035247 
                 0.252672 
                 −0.21782 
                 SELPLG 
               
               
                 NM_002940.1 
                 0.035714 
                 0.035247 
                 0.112373 
                 −0.22731 
                 ABCE1 
               
               
                 AL550657 
                 0.035714 
                 0.035247 
                 0.069403 
                 −0.23303 
                 BSG 
               
               
                 BG387770 
                 0.035714 
                 0.035247 
                 0.032984 
                 −0.2362 
                 MGC32104 
               
               
                 AL050205.1 
                 0.035714 
                 0.04225 
                 0.352078 
                 −0.23748 
                 LOC113251 
               
               
                 NM_016653.1 
                 0.035714 
                 0.035247 
                 0.003387 
                 −0.23765 
                 ZAK 
               
               
                 AA742237 
                 0.035714 
                 0.035247 
                 0.120935 
                 −0.23853 
                 BAT2 
               
               
                 NM_021183.1 
                 0.035714 
                 0.035247 
                 0.069121 
                 −0.24239 
                 LOC57826 
               
               
                 AB014527.1 
                 0.035714 
                 0.035247 
                 0.005636 
                 −0.24315 
                 CLASP2 
               
               
                 AF091086.1 
                 0.035714 
                 0.035247 
                 0.124853 
                 −0.24621 
                 CL640 
               
               
                 NM_006748.1 
                 0.035714 
                 0.04225 
                 0.141473 
                 −0.24728 
                 SLA 
               
               
                 NM_025238.1 
                 0.035714 
                 0.035247 
                 0.046507 
                 −0.24841 
                 BTBD1 
               
               
                 NM_018638.2 
                 0.035714 
                 0.035247 
                 0.074405 
                 −0.24942 
                 EKI1 
               
               
                 NM_002913.1 
                 0.035714 
                 0.04225 
                 0.092197 
                 −0.24967 
               
               
                 NM_002863.1 
                 0.035714 
                 0.035247 
                 0.034567 
                 −0.25494 
                 PYGL 
               
               
                 AF226044.1 
                 0.035714 
                 0.035247 
                 0.023966 
                 −0.25679 
                 SNRK 
               
               
                 NM_016217.1 
                 0.035714 
                 0.035247 
                 0.01673 
                 −0.25733 
                 LOC51696 
               
               
                 AF084943.1 
                 0.035714 
                 0.035247 
                 0.024841 
                 −0.26011 
                 MINPP1 
               
               
                 N22548 
                 0.035714 
                 0.04225 
                 0.03686 
                 −0.26164 
                 ROCK1 
               
               
                 AF033850.1 
                 0.035714 
                 0.035247 
                 0.110532 
                 −0.26338 
                 PLD2 
               
               
                 NM_014445.1 
                 0.035714 
                 0.00747 
                 0.007058 
                 −0.26858 
                 SERP1 
               
               
                 NM_016196.1 
                 0.035714 
                 0.035247 
                 0.014278 
                 −0.27109 
                 KIAA0682 
               
               
                 NM_012252.1 
                 0.035714 
                 0.035247 
                 0.020625 
                 −0.27124 
                 TFEC 
               
               
                 W72082 
                 0.035714 
                 0.035247 
                 0.180599 
                 −0.27284 
                 C1QR1 
               
               
                 NM_016166.1 
                 0.035714 
                 0.035247 
                 0.071782 
                 −0.27429 
                 PIAS1 
               
               
                 NM_022470.1 
                 0.035714 
                 0.035247 
                 0.072884 
                 −0.27655 
                 WIG1 
               
               
                 NM_030797.1 
                 0.035714 
                 0.035247 
                 0.039197 
                 −0.27728 
                 DKFZP566A1524 
               
               
                 NM_002199.2 
                 0.035714 
                 0.035247 
                 0.250656 
                 −0.27789 
                 IRF2 
               
               
                 BC003360.1 
                 0.035714 
                 0.035247 
                 0.02171 
                 −0.27851 
                 DDX18 
               
               
                 NM_004504.2 
                 0.035714 
                 0.035247 
                 0.020834 
                 −0.27873 
                 HRB 
               
               
                 NM_012072.2 
                 0.035714 
                 0.035247 
                 0.118494 
                 −0.27892 
                 C1QR1 
               
               
                 NM_018230.1 
                 0.035714 
                 0.035247 
                 0.071301 
                 −0.28019 
                 NUP133 
               
               
                 NM_002727.1 
                 0.035714 
                 0.04225 
                 0.038559 
                 −0.28438 
                 PRG1 
               
               
                 BC005338.1 
                 0.035714 
                 0.035247 
                 0.114062 
                 −0.28524 
                 CAPZA2 
               
               
                 U60521.1 
                 0.035714 
                 0.04225 
                 0.066643 
                 −0.29174 
                 CASP9 
               
               
                 AW188198 
                 0.035714 
                 0.035247 
                 0.005126 
                 −0.29178 
                 TNFAIP6 
               
               
                 BE908931 
                 0.035714 
                 0.035247 
                 0.017009 
                 −0.29572 
               
               
                 U64661 
                 0.035714 
                 0.04225 
                 0.030982 
                 −0.29704 
               
               
                 AL021395 
                 0.035714 
                 0.04225 
                 0.02084 
                 −0.29857 
               
               
                 NM_015176.1 
                 0.035714 
                 0.035247 
                 0.059688 
                 −0.299 
                 KIAA0483 
               
               
                 NM_002857.1 
                 0.035714 
                 0.04225 
                 0.04761 
                 −0.29944 
                 PXF 
               
               
                 U70451.1 
                 0.035714 
                 0.035247 
                 0.003458 
                 −0.30169 
                 MYD88 
               
               
                 NM_018042.1 
                 0.035714 
                 0.035247 
                 0.020209 
                 −0.30409 
                 FLJ10260 
               
               
                 AL049265.1 
                 0.035714 
                 0.04225 
                 0.136618 
                 −0.30472 
               
               
                 NM_024081.1 
                 0.035714 
                 0.035247 
                 0.020267 
                 −0.30513 
                 TMG4 
               
               
                 AI796169 
                 0.035714 
                 0.035247 
                 0.023959 
                 −0.31104 
                 GATA3 
               
               
                 AA160522 
                 0.035714 
                 0.035247 
                 0.056044 
                 −0.31114 
                 UBE3A 
               
               
                 AL136621.1 
                 0.035714 
                 0.04225 
                 0.06859 
                 −0.31538 
                 ZNF198 
               
               
                 NM_003051.1 
                 0.035714 
                 0.035247 
                 0.028776 
                 −0.3171 
                 SLC16A1 
               
               
                 AW572909 
                 0.035714 
                 0.035247 
                 0.027025 
                 −0.31713 
                 KIAA0874 
               
               
                 NM_017782.1 
                 0.035714 
                 0.04225 
                 0.017104 
                 −0.32078 
                 FLJ20360 
               
               
                 AK001821.1 
                 0.035714 
                 0.04225 
                 0.013182 
                 −0.32145 
                 MGC4170 
               
               
                 AW001847 
                 0.035714 
                 0.035247 
                 0.204195 
                 −0.32259 
                 APLP2 
               
               
                 BF196931 
                 0.035714 
                 0.04225 
                 0.003706 
                 −0.3226 
                 ZFP95 
               
               
                 AJ223333.1 
                 0.035714 
                 0.035247 
                 0.023593 
                 −0.32279 
                 DNMT2 
               
               
                 NM_005213.1 
                 0.035714 
                 0.04225 
                 0.216305 
                 −0.32285 
                 CSTA 
               
               
                 AF142419.1 
                 0.035714 
                 0.04225 
                 0.013772 
                 −0.33425 
                 QKI 
               
               
                 NM_020375.1 
                 0.035714 
                 0.035247 
                 0.07666 
                 −0.33473 
                 C12orf5 
               
               
                 NM_021970.1 
                 0.035714 
                 0.04225 
                 0.054987 
                 −0.33505 
                 MAP2K1IP1 
               
               
                 AK023816.1 
                 0.035714 
                 0.035247 
                 0.136952 
                 −0.34214 
               
               
                 NM_012238.3 
                 0.035714 
                 0.00747 
                 0.018308 
                 −0.3438 
                 SIRT1 
               
               
                 AF205218.1 
                 0.035714 
                 0.035247 
                 0.033088 
                 −0.34674 
                 NS1-BP 
               
               
                 NM_001660.2 
                 0.035714 
                 0.035247 
                 0.020387 
                 −0.35015 
                 ARF4 
               
               
                 NM_001196.1 
                 0.035714 
                 0.015406 
                 0.020544 
                 −0.35511 
                 BID 
               
               
                 NM_002970.1 
                 0.035714 
                 0.035247 
                 0.064201 
                 −0.35676 
                 SAT 
               
               
                 AC074331 
                 0.035714 
                 0.035247 
                 0.01515 
                 −0.35767 
               
               
                 M75715.1 
                 0.035714 
                 0.035247 
                 0.010802 
                 −0.3577 
                 ETF1 
               
               
                 NM_018657.2 
                 0.035714 
                 0.04225 
                 0.021807 
                 −0.3681 
                 MYNN 
               
               
                 NM_003370.1 
                 0.035714 
                 0.035247 
                 0.056143 
                 −0.37617 
                 VASP 
               
               
                 AI761561 
                 0.035714 
                 0.035247 
                 0.084393 
                 −0.37861 
                 HK2 
               
               
                 NM_002657.2 
                 0.035714 
                 0.035247 
                 0.043402 
                 −0.39004 
                 PLAGL2 
               
               
                 NM_004565.1 
                 0.035714 
                 0.035247 
                 0.086212 
                 −0.39025 
                 PEX14 
               
               
                 AK023837.1 
                 0.035714 
                 0.04225 
                 0.083366 
                 −0.39056 
                 KIAA1025 
               
               
                 AL117354 
                 0.035714 
                 0.00747 
                 0.011916 
                 −0.39754 
                 LOC50999 
               
               
                 NM_001356.2 
                 0.035714 
                 0.035247 
                 0.029134 
                 −0.41337 
                 DDX3 
               
               
                 NM_018573.1 
                 0.035714 
                 0.015406 
                 0.00529 
                 −0.41757 
                 PRO1068 
               
               
                 NM_030799.1 
                 0.035714 
                 0.035247 
                 0.075235 
                 −0.42088 
                 SMAP-5 
               
               
                 AA524053 
                 0.035714 
                 0.04225 
                 0.031361 
                 −0.42442 
               
               
                 NM_002748.1 
                 0.035714 
                 0.035247 
                 0.023266 
                 −0.42563 
                 MAPK6 
               
               
                 NM_002053.1 
                 0.035714 
                 0.035247 
                 0.053201 
                 −0.43747 
                 GBP1 
               
               
                 AB023227.1 
                 0.035714 
                 0.04225 
                 0.003343 
                 −0.43985 
                 KIAA1010 
               
               
                 AW193511 
                 0.035714 
                 0.035247 
                 0.012709 
                 −0.44652 
                 HIS1 
               
               
                 AW272611 
                 0.035714 
                 0.04225 
                 0.024277 
                 −0.44899 
                 TMPO 
               
               
                 AI671747 
                 0.035714 
                 0.00747 
                 0.02288 
                 −0.45263 
                 MISS 
               
               
                 AI688580 
                 0.035714 
                 0.035247 
                 0.035918 
                 −0.45484 
                 SURB7 
               
               
                 NM_002502.1 
                 0.035714 
                 0.035247 
                 0.107712 
                 −0.45745 
                 NFKB2 
               
               
                 NM_004267.1 
                 0.035714 
                 0.04225 
                 0.030352 
                 −0.47177 
                 CHST2 
               
               
                 X15132.1 
                 0.035714 
                 0.035247 
                 0.041452 
                 −0.47259 
                 SOD2 
               
               
                 NM_012093.1 
                 0.035714 
                 0.035247 
                 0.011606 
                 −0.47474 
                 AK5 
               
               
                 D26067.1 
                 0.035714 
                 0.035247 
                 0.003438 
                 −0.47644 
                 KIAA0033 
               
               
                 NM_001166.2 
                 0.035714 
                 0.04225 
                 0.015252 
                 −0.48334 
                 BIRC2 
               
               
                 NM_016545.1 
                 0.035714 
                 0.035247 
                 0.029826 
                 −0.48723 
                 IER5 
               
               
                 NM_021122.2 
                 0.035714 
                 0.035247 
                 0.070882 
                 −0.49855 
                 FACL2 
               
               
                 NM_017936.1 
                 0.035714 
                 0.035247 
                 0.008293 
                 −0.5016 
                 FLJ20707 
               
               
                 NM_000574.1 
                 0.035714 
                 0.035247 
                 0.022743 
                 −0.50532 
                 DAF 
               
               
                 AL050144.1 
                 0.035714 
                 0.015406 
                 0.000822 
                 −0.52839 
                 ZNF363 
               
               
                 NM_005346.2 
                 0.035714 
                 0.035247 
                 0.10824 
                 −0.5359 
                 HSPA1B 
               
               
                 NM_022725.1 
                 0.035714 
                 0.035247 
                 0.023814 
                 −0.53779 
                 FANCF 
               
               
                 AI348010 
                 0.035714 
                 0.035247 
                 0.226116 
                 −0.54348 
               
               
                 AI927993 
                 0.035714 
                 0.035247 
                 0.054067 
                 −0.54478 
                 OSBP 
               
               
                 BE327172 
                 0.035714 
                 0.035247 
                 0.091317 
                 −0.54925 
                 JUN 
               
               
                 AI741876 
                 0.035714 
                 0.00747 
                 0.025182 
                 −0.57505 
               
               
                 NM_003107.1 
                 0.035714 
                 0.035247 
                 0.078087 
                 −0.59709 
                 SOX4 
               
               
                 BE383139 
                 0.035714 
                 0.035247 
                 0.00951 
                 −0.60058 
                 RARA 
               
               
                 NM_018398.1 
                 0.035714 
                 0.035247 
                 0.016221 
                 −0.603 
                 CACNA2D3 
               
               
                 NM_000201.1 
                 0.035714 
                 0.035247 
                 0.036915 
                 −0.62554 
                 ICAM1 
               
               
                 NM_002229.1 
                 0.035714 
                 0.035247 
                 0.129802 
                 −0.64436 
                 JUNB 
               
               
                 NM_021960.1 
                 0.035714 
                 0.04225 
                 0.024176 
                 −0.66914 
                 MCL1 
               
               
                 NM_016010.1 
                 0.035714 
                 0.00747 
                 0.015684 
                 −0.68307 
                 LOC51101 
               
               
                 NM_004417.2 
                 0.035714 
                 0.035247 
                 0.043377 
                 −0.68458 
                 DUSP1 
               
               
                 NM_025195.1 
                 0.035714 
                 0.035247 
                 0.055882 
                 −0.68638 
                 C8FW 
               
               
                 NM_004418.2 
                 0.035714 
                 0.035247 
                 0.306591 
                 −0.68934 
                 DUSP2 
               
               
                 AB017493.1 
                 0.035714 
                 0.015406 
                 0.010224 
                 −0.6982 
                 COPEB 
               
               
                 AF064824.1 
                 0.035714 
                 0.035247 
                 0.010071 
                 −0.70109 
                 RIPK2 
               
               
                 NM_005354.2 
                 0.035714 
                 0.035247 
                 0.04394 
                 −0.70667 
                 JUND 
               
               
                 NM_006469.1 
                 0.035714 
                 0.035247 
                 0.006453 
                 −0.71493 
                 NS1-BP 
               
               
                 NM_006290.1 
                 0.035714 
                 0.035247 
                 0.155375 
                 −0.73437 
                 TNFAIP3 
               
               
                 AI339541 
                 0.035714 
                 0.035247 
                 0.039838 
                 −0.76402 
                 JUND 
               
               
                 AF087853.1 
                 0.035714 
                 0.035247 
                 0.076647 
                 −0.77217 
                 GADD45B 
               
               
                 AL031602 
                 0.035714 
                 0.035247 
                 0.015158 
                 −0.78504 
               
               
                 BF575213 
                 0.035714 
                 0.035247 
                 0.007144 
                 −0.78651 
               
               
                 M68956.1 
                 0.035714 
                 0.00747 
                 0.001933 
                 −0.79718 
                 MARCKS 
               
               
                 NM_004907.1 
                 0.035714 
                 0.035247 
                 0.006503 
                 −0.81053 
                 ETR101 
               
               
                 AW083357 
                 0.035714 
                 0.035247 
                 0.009893 
                 −0.81405 
                 IL1RN 
               
               
                 AF153820.1 
                 0.035714 
                 0.035247 
                 0.004403 
                 −0.82757 
                 KCNJ2 
               
               
                 AI608725 
                 0.035714 
                 0.035247 
                 0.010119 
                 −0.83319 
                 ICAM1 
               
               
                 NM_000958.1 
                 0.035714 
                 0.015406 
                 0.003112 
                 −0.86354 
                 PTGER4 
               
               
                 AA083483 
                 0.035714 
                 0.035247 
                 0.012228 
                 −0.88452 
                 FTH1 
               
               
                 NM_002664.1 
                 0.035714 
                 0.00747 
                 0.000855 
                 −0.88664 
                 PLEK 
               
               
                 AL031602 
                 0.035714 
                 0.015406 
                 0.00038 
                 −0.88673 
               
               
                 W27419 
                 0.035714 
                 0.015406 
                 0.000361 
                 −0.95575 
               
               
                 NM_002852.1 
                 0.035714 
                 0.035247 
                 0.001716 
                 −0.97365 
                 PTX3 
               
               
                 NM_001964.1 
                 0.035714 
                 0.035247 
                 0.068287 
                 −0.99045 
                 EGR1 
               
               
                 AF078077.1 
                 0.035714 
                 0.035247 
                 0.017058 
                 −1.003 
                 GADD45B 
               
               
                 NM_015714.1 
                 0.035714 
                 0.035247 
                 0.210858 
                 −1.05996 
                 G0S2 
               
               
                 BC004490.1 
                 0.035714 
                 0.035247 
                 0.068201 
                 −1.06388 
                 FOS 
               
               
                 AI738896 
                 0.035714 
                 0.035247 
                 0.071526 
                 −1.09453 
                 TNFAIP3 
               
               
                 AW973834 
                 0.035714 
                 0.035247 
                 0.030817 
                 −1.09468 
               
               
                 NM_004895.1 
                 0.035714 
                 0.035247 
                 0.004992 
                 −1.10724 
                 CIAS1 
               
               
                 U08839.1 
                 0.035714 
                 0.035247 
                 0.030968 
                 −1.1245 
                 PLAUR 
               
               
                 BC005020.1 
                 0.035714 
                 0.035247 
                 0.022893 
                 −1.13801 
                 PPIF 
               
               
                 NM_005627.1 
                 0.035714 
                 0.035247 
                 0.010834 
                 −1.16132 
                 SGK 
               
               
                 NM_015675.1 
                 0.035714 
                 0.035247 
                 0.022251 
                 −1.16822 
                 GADD45B 
               
               
                 AI433595 
                 0.035714 
                 0.015406 
                 0.002395 
                 −1.17663 
                 PLEK 
               
               
                 NM_002135.1 
                 0.035714 
                 0.035247 
                 0.009942 
                 −1.19934 
                 NR4A1 
               
               
                 NM_003407.1 
                 0.035714 
                 0.035247 
                 0.0028 
                 −1.30448 
                 ZFP36 
               
               
                 NM_004233.1 
                 0.035714 
                 0.035247 
                 0.045128 
                 −1.33091 
                 CD83 
               
               
                 NM_001432.1 
                 0.035714 
                 0.035247 
                 0.001942 
                 −1.33633 
                 EREG 
               
               
                 NM_002228.2 
                 0.035714 
                 0.035247 
                 0.007227 
                 −1.34352 
                 JUN 
               
               
                 NM_004049.1 
                 0.035714 
                 0.035247 
                 0.004927 
                 −1.41895 
                 BCL2A1 
               
               
                 U83981 
                 0.035714 
                 0.035247 
                 0.005806 
                 −1.46885 
                 PPP1R15A 
               
               
                 NM_006018.1 
                 0.035714 
                 0.035247 
                 0.002094 
                 −1.50671 
                 HM74 
               
               
                 BG491844 
                 0.035714 
                 0.035247 
                 0.011957 
                 −1.61438 
                 JUN 
               
               
                 BC002646.1 
                 0.035714 
                 0.035247 
                 0.002438 
                 −1.64136 
                 JUN 
               
               
                 NM_000963.1 
                 0.035714 
                 0.035247 
                 0.025772 
                 −1.65759 
                 PTGS2 
               
               
                 AY029180.1 
                 0.035714 
                 0.035247 
                 0.011082 
                 −1.69399 
                 PLAUR 
               
               
                 NM_014330.2 
                 0.035714 
                 0.035247 
                 0.003245 
                 −1.74665 
                 PPP1R15A 
               
               
                 NM_003897.1 
                 0.035714 
                 0.035247 
                 0.002981 
                 −1.89968 
                 IER3 
               
               
                 M57731.1 
                 0.035714 
                 0.035247 
                 0.001811 
                 −1.9703 
                 CXCL2 
               
               
                 NM_000584.1 
                 0.035714 
                 0.035247 
                 0.030747 
                 −2.54298 
                 IL8 
               
               
                 NM_000576.1 
                 0.035714 
                 0.035247 
                 0.000992 
                 −2.66025 
                 IL1B 
               
               
                 M15330 
                 0.035714 
                 0.035247 
                 0.001505 
                 −2.71142 
                 IL1B 
               
               
                   
               
            
           
         
       
     
      It is appreciated that certain features of the invention, which are, for clarity, described in the context of separate embodiments, may also be provided in combination in a single embodiment. Conversely, various features of the invention, which are, for brevity, described in the context of a single embodiment, may also be provided separately or in any suitable subcombination.  
      Although the invention has been described in conjunction with specific embodiments thereof, it is evident that many alternatives, modifications and variations will be apparent to those skilled in the art. Accordingly, it is intended to embrace all such alternatives, modifications and variations that fall within the spirit and broad scope of the appended claims. All publications, patents, patent applications and sequences identifies by a GenBank accession number mentioned in this specification are herein incorporated in their entirety by reference into the specification, to the same extent as if each individual publication, patent, patent application or sequence was specifically and individually indicated to be incorporated herein by reference. In addition, citation or identification of any reference in this application shall not be construed as an admission that such reference is available as prior art to the present invention.