Patent Publication Number: US-7711492-B2

Title: Methods for diagnosing lymphoma types

Description:
RELATED APPLICATIONS 
     The present utility application claims priority to provisional patent application U.S. Ser. No. 60/500,377 (Staudt et al.), filed Sep. 3, 2003, the disclosure of which is incorporated by reference herein in its entirety, including but not limited to the electronic data submitted on 21 CD-ROMs accompanying the provisional application. 
    
    
     FIELD OF THE INVENTION 
     The present invention relates to the field of diagnosing, identifying, and predicting survival in lymphoproliferative disorders. 
     REFERENCE TO TABLES SUBMITTED ON COMPACT DISC 
     Tables 2-1723 and 1725-2358 are contained on 21 CD-ROMs provided herewith. These CD-ROMs are numbered 1-21 of 22. Each CD-ROM is provided in two copies, 15 for a total of 44 CD-ROMs. The name, size, and date of creation for each file is presented in the List of Materials Submitted by Compact Disc at the end of this specification and in the file entitled “Tableofcontents.txt,” located on CD number 21 of 22. The name of each file incorporates the number of the corresponding table. Any reference to a table or file should be considered an incorporation by reference of the contents of the table and/or file at that particular place in the specification. 
     REFERENCE TO COMPUTER PROGRAM LISTING APPENDIX SUBMITTED ON COMPACT DISC 
     A computer program listing appendix is contained on one CD-ROM provided herewith. Three copies of this CD-ROM, numbered 22 of 22, are provided. The computer program listing appendix contains files related to the implementation of an algorithm for determining lymphoma type. The name, size, and date of creation for each file in the computer program listing appendix is presented in the file entitled “Table_of_contents.txt,” located on CD-ROM 22. Any reference to a file contained in the computer program listing appendix should be considered an incorporation by reference of the contents of that file at that particular place in the specification. 
     BACKGROUND OF INVENTION 
     A variety of systems for identifying and classifying lymphomas have been proposed over the last 20 years. In the 1980&#39;s, the Working Formulation was introduced as a method of classifying lymphomas based on morphological and clinical characteristics. In the 1990&#39;s, the Revised European-American Lymphoma (REAL) system was introduced in an attempt to take into account immunophenotypic and genetic characteristics in classifying lymphomas (Harris 1994). The most recent standard, set forth by the World Health Organization (WHO), attempts to build on these previous systems (Jaffe 2001). The WHO classification of lymphomas is based on several factors, including tumor morphology, immunophenotype, recurrent genetic abnormalities, and clinical features. Table 1, below, contains a list of the B and T cell neoplasms that have been recognized by the WHO classification. Each malignancy is listed according to its WHO classification nomenclature, followed by a WHO classification number. 
                             TABLE 1               Category   Name   WHO ID #                                    B-cell neoplasms                         Precursor B-cell   Precursor B-cell lymphoblastic   9835/3       neoplasms   leukemia           Precursor B-cell lymphoblastic   9728/3           lymphoma       Mature B-cell   Chronic lymphocytic leukemia   9823/3       neoplasms           Small lymphocytic lymphoma   9670/3           B-cell prolymphocytic leukemia   9833/3           Lymphoplasmacytic lymphoma   9671/3           Splenic marginal zone   9689/3           lymphoma           Hairy cell leukemia   9940/3           Plasma cell myeloma   9732/3           Solitary plasmacytoma of bone   9731/3           Extraosseous plasmacytoma   9734/3           Extranodal marginal zone B-cell   9699/3           lymphoma of mucosa-           associated lymphoid tissue           (MALT lymphoma)           Nodal marginal zone B-cell   9699/3           lymphoma           Follicular lymphoma (Grade 1,   9690/3           2, 3a, 3b)           Mantle cell lymphoma   9673/3           Diffuse large B-cell lymphoma   9680/3           Mediastinal (thymic) large B-cell   9679/3           lymphoma           Intravascular large B-cell   9680/3           lymphoma           Primary effusion lymphoma   9678/3           Burkitt lymphoma   9687/3           Burkitt leukemia   9826/3       B-cell proliferations   Lymphomatoid granulomatosis   9766/1       of uncertain       malignant potential           Post-transplant   9970/1           lymphoproliferative disorder,           polymorphic                 T-cell and NK-cell neoplasms                         Precursor T-cell and   Precursor T lymphoblastic   9837/3       NK-cell neoplasms   leukemia           Precursor T lymphoblastic   9729/3           lymphoma           Blastic NK-cell lymphoma   9727/3       Mature T-cell and   T-cell prolymphocytic leukemia   9834/3       NK-cell neoplasms           T-cell large granular   9831/3           lymphocytic leukemia           Aggressive NK-cell leukemia   9948/3           Adult T-cell leukemia/lymphoma   9827/3           Extranodal NK-/T-cell   9719/3           lymphoma, nasal type           Enteropathy-type T-cell   9717/3           lymphoma           Hepatosplenic T-cell lymphoma   9716/3           Subcutaneous panniculitis-like   9708/3           T-cell lymphoma           Mycosis fungoides   9700/3           Sezary syndrome (9701/3)   9701/3           Primary cutaneous anaplastic   9718/3           large cell lymphoma (C-ALCL)           Peripheral T-cell lymphoma,   9702/3           unspecified           Angioimmunoblastic T-cell   9705/3           lymphoma           Anaplastic large cell lymphoma   9714/3       T-cell proliferation   Lymphomatoid papulosis   9718/3       of uncertain       malignant potential       Hodgkin lymphoma   Nodular lymphocyte   9659/3           predominant Hodgkin           lymphoma           Classical Hodgkin lymphoma   9650/3           Classical Hodgkin lymphoma,   9663/3           nodular sclerosis           Classical Hodgkin lymphoma,   9651/3           lymphocyte-rich           Classical Hodgkin lymphoma,   9652/3           mixed cellularity           Classical Hodgkin lymphoma,   9653/3           lymphocyte depleted                    
Other diagnoses that have not been given WHO diagnostic numbers include HIV-associated lymphoma, germinal center B cell-like subtype of diffuse large B cell lymphoma, activated B cell-like subtype of diffuse large B-cell lymphoma, follicular hyperplasia (non-malignant), and infectious mononucleosis (non-malignant).
 
     Although the WHO classification has proven useful in patient management and treatment, patients assigned to the same WHO diagnostic category often have noticeably different clinical outcomes. In many cases, these different outcomes appear to be due to molecular differences between tumors that cannot be readily observed by analyzing tumor morphology. More precise methods are needed for identifying and classifying lymphomas based on their molecular characteristics. 
     SUMMARY OF THE INVENTION 
     Accurate identification of lymphoma type or subtype in a subject suffering from a lymphoproliferative disorder is important for developing an appropriate therapeutic strategy. Previous attempts have been made to identify lymphomas using gene expression data obtained using a microarray. However, there is a need in the art for more accurate and predictive methods of analyzing this gene expression data. In addition, there is a need for more specific and efficient methods of obtaining gene expression data. 
     The present invention discloses a novel microarray for obtaining gene expression data to be used in identifying lymphoma types and predicting survival in a subject. The present invention further discloses a variety of methods for analyzing gene expression data obtained from a lymphoma sample, and specific algorithms for predicting survival and clinical outcome in a subject suffering from a lymphoma. 
     One embodiment of the present invention provides a composition comprising the set of probes listed in Table 2, contained in the file entitled “Table — 0002_LymphDx_Probe_List.txt.” Preferably, this composition comprises a microarray. 
     In another embodiment, the present invention provides a method of generating a survival predictor for a particular lymphoma type. In this method, one or more biopsy samples that have been diagnosed as belonging to a particular lymphoma type are obtained. Gene expression data is obtained for these samples, and genes with expression patterns associated with longer or shorter survival are identified. Hierarchical clustering is performed to group these genes into gene expression signatures, and the expression of all genes within each signature are averaged to obtain a gene expression signature value for each signature. These gene expression signature values are then used to generate a multivariate survival predictor. 
     In another embodiment, the present invention provides a method for predicting survival in a follicular lymphoma (FL) subject. In this method, a biopsy sample is obtained from the subject and gene expression data is obtained from the biopsy sample. The expression level of those genes belonging to an immune response-1 or immune response-2 gene expression signature are averaged to generate gene expression signature values for each signature. A survival predictor score is then calculated using an equation: [2.71*(immune response-2 gene expression signature value)]−[2.36*(immune response-1 gene expression signature value)]. A higher survival predictor score is associated with a less favorable outcome. In one embodiment, the gene expression data used in this method is obtained using a microarray. 
     In another embodiment, the present invention provides another method for predicting survival in a follicular lymphoma (FL) subject. In this method, a biopsy sample is obtained from the subject and gene expression data is obtained from the biopsy sample. The expression level of those genes belonging to a B cell differentiation, T-cell, or macrophage gene expression signature are averaged to generate gene expression signature values for each signature. A survival predictor score is then calculated using an equation: [2.053*(macrophage gene expression signature value)]−[2.344*(T-cell gene expression signature value)]−[0.729*(B-cell gene expression signature value)]. A higher survival predictor score is associated with a less favorable outcome. In one embodiment, the gene expression data used in this method is obtained using a microarray. 
     In another embodiment, the present invention provides yet another method for predicting survival in a follicular lymphoma (FL) subject. In this method, a biopsy sample is obtained from the subject and gene expression data is obtained from the biopsy sample. The expression level of those genes belonging to a macrophage, T-cell, or B-cell differentiation gene expression signature are averaged to generate gene expression signature values for each signature. A survival predictor score is then calculated using an equation: [1.51*(macrophage gene expression signature value)]−[2.11*(T-cell gene expression signature value)]−[0.505*(B-cell differentiation gene expression signature value)]. A higher survival predictor score is associated with a less favorable outcome. In one embodiment, the gene expression data used in this method is obtained using a microarray. 
     In another embodiment, the present invention provides a method for predicting survival in a diffuse large B cell lymphoma (DLBCL) subject. In this method, a biopsy sample is obtained from the subject and gene expression data is obtained from the biopsy sample. The expression level of those genes belonging to an ABC DLBCL high, lymph node, or MHC class II gene expression signature are averaged to generate gene expression signature values for each signature. A survival predictor score is then calculated using an equation: [0.586*(ABC DLBCL high gene expression signature value)]−[0.468*(lymph node gene expression signature value)]−[0.336*(MHC class II gene expression signature value)]. A higher survival predictor score is associated with a less favorable outcome. In one embodiment, the gene expression data used in this method is obtained using a microarray. 
     In another embodiment, the present invention provides another method for predicting survival in a diffuse large B cell lymphoma (DLBCL) subject. In this method, a biopsy sample is obtained from the subject and gene expression data is obtained from the biopsy sample. The expression level of those genes belonging to a lymph node, germinal B cell, proliferation, or MHC class II gene expression signature are averaged to generate gene expression signature values for each signature. A survival predictor score is then calculated using an equation: [−0.4337*(lymph node gene expression signature)]+[0.09*(proliferation gene expression signature)]−[0.4144*(germinal center B-cell gene expression signature)]−[0.2006*(MHC class II gene expression signature)]. A higher survival predictor score is associated with a less favorable outcome. In one embodiment, the gene expression data used in this method is obtained using a microarray. 
     In another embodiment, the present invention provides yet another method for predicting survival in a diffuse large B cell lymphoma (DLBCL) subject. In this method, a biopsy sample is obtained from the subject and gene expression data is obtained from the biopsy sample. The expression level of those genes belonging to a lymph node, germinal B cell, or MHC class II gene expression signature are averaged to generate gene expression signature values for each signature. A survival predictor score is then calculated using an equation: [−0.32*(lymph node gene expression signature)]−[0.176*(germinal B cell gene expression signature)]−[0.206*(MHC class II gene expression signature)]. A higher survival predictor score is associated with a less favorable outcome. In one embodiment, the gene expression data used in this method is obtained using a microarray. In another embodiment, the gene expression data is obtained using RT-PCR. 
     In another embodiment, the present invention provides a method for predicting survival in a mantle cell lymphoma (MCL) subject. In this method, a biopsy sample is obtained from the subject and gene expression data is obtained from the biopsy sample. The expression level of those genes belonging to a proliferation gene expression signature are averaged to generate a gene expression signature value. A survival predictor score is then calculated using an equation: [1.66*(proliferation gene expression signature value)]. A higher survival predictor score is associated with a less favorable outcome. In one embodiment, the gene expression data used in this method is obtained using a microarray. 
     In another embodiment, the present invention provides a method for determining the probability that a sample X belongs to a first lymphoma type or a second lymphoma type. In this method, a set of genes is identified that is differentially expressed between the two lymphoma types in question, and a set of scale factors representing the difference in expression between the lymphoma types for each of these genes are calculated. A series of linear predictor scores are generated for samples belonging to either of the two lymphoma types based on expression of these genes. Gene expression data is then obtained for sample X, and a linear predictor score is calculated for this sample. The probability that sample X belongs to the first lymphoma type is calculated using an equation that incorporates the linear predictor score of sample X and the mean and variance of the linear predictor scores for the known samples of either lymphoma type. 
     In another embodiment, the present invention provides a method for determining the lymphoma type of a sample X. In this method, a set of genes is identified that is differentially expressed between a first lymphoma type and a second lymphoma type, and a set of scale factors representing the difference in expression of each of these genes between the two lymphoma types are calculated. A series of linear predictor scores are generated for samples belonging to either of the two lymphoma types based on expression of these genes. Gene expression data is then obtained for sample X, and a linear predictor score is calculated for this sample. The probability that sample X belongs to the first lymphoma type is calculated using an equation that incorporates the linear predictor score of sample X and the mean and variance of the linear predictor scores for the known samples of either lymphoma type. This entire process is then repeated with various lymphoma types being substituted for the first lymphoma type, the second lymphoma type, or both. 
     In another embodiment, the present invention provides another method for determining the lymphoma type of a sample X. In this method, a series of lymphoma type pairs are created, with each pair consisting of a first lymphoma type and a second lymphoma type. For each type pair, gene expression data is obtained for a set of genes, and a series of scale factors representing the difference in expression of each of these genes between the two lymphoma types are calculated. A subset of z genes with the largest scale factors are identified, and a series of linear predictor scores are generated for samples belonging to either of the two lymphoma types. Linear predictor scores are calculated for anywhere from 1 to z of these genes. The number of genes from 1 to z that results in the largest difference in linear predictor scores between the two lymphoma types is selected, and gene expression data for these genes is obtained for sample X. A linear predictor score is generated for sample X, and the probability that the sample belongs to the first lymphoma type is calculated using an equation that incorporates the linear predictor score for sample X and the mean and variance of the linear predictor scores for the known samples of either lymphoma type. 
     In another embodiment, the present invention provides another method for determining the lymphoma type of a sample X. In this method, a series of lymphoma type pairs are created, with each pair consisting of a first lymphoma type and a second lymphoma type. For each type pair, gene expression data is obtained for a set of genes, and a series of scale factors representing the difference in expression of each of these genes between the two lymphoma types are calculated. The set of genes is divided into gene-list categories indicating correlation with a gene expression signature. Within each gene-list category, a subset of z genes with the largest scale factors are identified, and a series of linear predictor scores are generated for samples belonging to either of the two lymphoma types. Linear predictor scores are calculated for anywhere from 1 to z of these genes. The number of genes from 1 to z that results in the largest difference in linear predictor scores between the two lymphoma types is selected, and gene expression data for these genes is obtained for sample X. A linear predictor score is generated for sample X, and the probability q that the sample belongs to the first lymphoma type is calculated using an equation that incorporates the linear predictor score for sample X and the mean and variance of the linear predictor scores for the known samples of either lymphoma type. A high probability q indicates that sample X belongs to the first lymphoma type, a low probability q indicates that sample X belongs to the second lymphoma type, and a middle probability q indicates that sample X belongs to neither lymphoma type. The cut-off point between high, middle, and low probability values is determined by ranking samples of known lymphoma type according to their probability values, then analyzing every possible cut-off point between adjacent samples using the equation: 3.99*[(% of first lymphoma type misidentified as second lymphoma type)+(% of second lymphoma type misidentified as a first lymphoma type)]+[(% of first lymphoma type identified as belonging to neither lymphoma type)+(% of second lymphoma type identified as belonging to neither lymphoma type)]. The final cut-off points are those that minimize the value of this equation. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIG. 1 : Method for identifying lymphoma type. Flow chart depicts a general method for identifying lymphoma type using gene expression data. 
         FIG. 2 : Survival signature analysis. Flow chart depicts method for developing a lymphoma survival predictor based on gene expression patterns. 
         FIG. 3 : FL survival data. Survival data for 191 subjects diagnosed with FL. Median age at diagnosis was 51 years (ranging from 23 to 81 years), and the subjects had a median follow-up of 6.6 years (8.1 years for survivors, with a range of &lt;1 to 28.2 years). 
         FIG. 4 : Hierarchical clustering of survival associated genes in FL samples. Each column represents a single FL sample, while each row represents a single gene. Relative gene expression is depicted according to the scale at the bottom of the figure. The dendrogram to the left indicates the degree to which the expression pattern of each gene is correlated with that of the other genes. The bars indicate sets of coordinately regulated genes defined as gene expression signatures. Genes comprising the immune response-1 and immune response-2 gene expression signature are listed on the right. 
         FIG. 5 : Kaplan-Meier plot of survival in FL samples based on survival predictor scores. 191 FL samples were divided into quartiles based on their survival predictor scores. The survival predictor scores were calculated using the equation:
 [(2.71*immune response-2 gene expression signature value)]−[(2.36×immune response-1 gene expression signature value)]. 
         FIG. 6 : Kaplan-Meier plot of survival in FL samples based on IPI score. 96 FL samples were divided into three groups based on their IPI scores. 
         FIG. 7 : Kaplan-Meier plot of survival in FL samples with low or high risk IPI scores based on survival predictor scores. 96 FL samples with low risk (left panel) or intermediate risk (right panel) IPI scores were divided into quartiles based on their survival predictor scores. The survival predictor scores were calculated using the equation: [(2.71*immune response-2 gene expression signature value)]−[(2.36×immune response-1 gene expression signature value)]. 
         FIG. 8 : Kaplan-Meier plot of survival in FL samples based on survival predictor scores. 191 FL samples were divided into quartiles based on their survival predictor scores. The survival predictor scores were calculated using the equation:
 [2.053*(macrophage gene expression signature value)]−[2.344*(T-cell gene expression signature value)]−[0.729*(B-cell differentiation gene expression signature value)]. 
         FIG. 9 : Kaplan-Meier plot of survival in FL samples based on survival predictor scores. 191 FL samples were divided into quartiles based on their survival predictor scores. The survival predictor scores were calculated using the equation:
 [1.51*(macrophage gene expression signature value)]−[2.11*(T-cell gene expression signature value)]−[0.505*(B-cell differentiation gene expression signature value)]. 
         FIG. 10 : Kaplan-Meier plot of survival in DLBCL samples based on survival predictor scores. 231 DLBCL samples were divided into quartiles based on their survival predictor scores. The survival predictor scores were calculated using the equation: [0.586*(ABC DLBCL high gene expression signature value)]−[0.468*(lymph node gene expression signature value)]−[(0.336*MHC Class II gene expression signature value)]. 
         FIG. 11 : Kaplan-Meier plot of survival in DLBCL samples based on survival predictor scores. 200 DLBCL samples were divided into quartiles based on their survival predictor scores. The survival predictor scores were calculated using the equation: [−0.4337*(lymph node gene expression signature value)]+[0.09*(proliferation gene expression signature value)]−[0.4144*(germinal center B-cell gene expression signature value)]−[0.2006*(MHC class II gene expression signature value)]. 
         FIG. 12 : Kaplan-Meier plot of survival in DLBCL samples based on survival predictor scores. 200 DLBCL samples were divided into quartiles based on their survival predictor scores. The survival predictor scores were calculated using the equation: [−0.32*(lymph node gene expression signature value)]−[0.176*(germinal center B-cell gene expression signature value)]−[0.206*(MHC class II gene expression signature value)]. 
         FIG. 13 : Kaplan-Meier plot of survival in MCL samples based on survival predictor scores. 21 MCL samples were divided into two equivalent groups based on their survival predictor scores. The survival predictor scores were calculated using the equation: 1.66*(proliferation gene expression signature value). 
         FIG. 14 : Kaplan-Meier plot of survival in MCL samples based on survival predictor scores. 21 MCL samples were divided into two equivalent groups based on their survival predictor scores. The survival predictor scores were calculated using the equation: 1.66*(proliferation gene expression signature value). 
         FIG. 15 : Predicting lymphoma type using Bayesian analysis. Bayes&#39; rule can be used to determine the probability that an unknown sample belongs to a first lymphoma type rather than a second lymphoma type. A linear predictor score is generated for the sample, and the probability that the sample belongs to the first lymphoma type is determined based on the distribution of linear predictor scores within the first and second lymphoma type. 
         FIG. 16 : Performance of MCL predictor model. Results of the gene-expression based predictor model for MCL are shown for three models (MCL vs. ABC, MCL vs. GCB, MCL vs. SLL). Performance is shown for both the training set and the validation set. 
         FIG. 17 : Gene expression-based identification of DLBCL. Expression levels for 27 genes in a subgroup predictor are shown for 274 DLBCL samples. Expression levels are depicted according to the scale shown at the left. The 14 genes used to predict the DLBCL subgroups in the Affymetrix data set are indicated with asterisks. The probabilities that the DLBCL samples belong to the ABC or GCB subtypes are graphed at the top, and the DLBCL cases are arranged accordingly. Cases belonging to either ABC or GCB with 90% or greater probability are indicated. 
         FIG. 18 : Performance of DLBCL subtype predictor model. Assignments of DLBCL samples to the ABC or GCB subtypes based on hierarchical clustering vs. the predictor model disclosed herein are compared within the training, validation, and total set of samples. 
         FIG. 19 : Relationship of gene expression in normal B cell subpopulations to DLBCL subtypes. Relative gene expression in the indicated purified B cell populations is depicted according to the scale in  FIG. 17 . The P value of the difference in expression of these genes between the GCB and ABC DLBCL subtypes is shown, and the subtype with the higher expression is shown is indicated (blue, ABC; orange, GCB). A. DLBCL subtype distinction genes that are more highly expressed in germinal center B cells than at other B cell differentiation stages. B. DLBCL subtype distinction genes that are more highly expressed in plasma cells than at other B cell differentiation stages. 
         FIG. 20 : Identification of a PMBL gene expression signature. A. Hierarchical clustering identified a set of 23 PMBL signature genes that were more highly expressed in most lymphomas with a clinical diagnosis of PMBL than in lymphomas assigned to the GCB or ABC subtypes. Each row presents gene expression measurements from a single Lymphochip microarray feature representing the genes indicated. Each column represents a single lymphoma biopsy sample. Relative gene expression is depicted according to the scale shown. B. Hierarchical clustering of the lymphoma biopsy samples based on expression of the PMBL signature genes identified in (A). A “core” cluster of lymphoma cases was identified that highly expressed the PMBL signature genes. 
         FIG. 21 : Development of a gene expression-based molecular diagnosis of PMBL. A. A PMBL predictor was created based on expression of the 46 genes shown. Relative gene expression for each lymphoma biopsy sample is presented according to the scale shown in  FIG. 20 . The probability that each sample is PMBL or DLBCL based on gene expression is shown at the top. B. The PMBL predictor was used to classify 274 lymphoma samples as PMBL or DLBCL. Prediction results are summarized on the right, and the relative gene expression for each case that was classified by the predictor as PMBL is shown on the left. Average expression of each gene in samples classified as DLBCL is also shown. The 20 genes listed are those represented on the Lymphochip that were more highly expressed in PMBL than in DLBCL. Not shown are eight genes from the PMBL predictor that were more highly expressed in DLBCL than in PMBL. 
         FIG. 22 : Clinical characteristics of PMBL patients. Kaplan-Meier plot of overall survival in PMBL, GCB, and ABC patients after chemotherapy. 
         FIG. 23 : Optimization of gene number in lymphoma predictor. The optimal number of genes for inclusion in the lymphoma type predictor model is that number which generates a maximum t-statistic when comparing the LPS of two samples from different lymphoma types. 
         FIG. 24 : LPS distribution among FL and DLBCL/BL samples. Standard and proliferation LPSs for FL (×) and DLBCL/BL (+) samples. Dotted lines indicate standard deviations from the fitted multivariate normal distributions. 
         FIG. 25 : Determination of cut-off points for lymphoma classification. The cut-off points between samples classified as DLBCL/BL, FL, or unclassified were optimized to minimize the number of samples classified as the wrong lymphoma type. The optimal lower cut-off point was at q=0.49, while the optimal upper cut-off point was at q=0.84. 
         FIG. 26 : Division of LPSs among FL and DLBCL/FL samples. Illustration of how the cut-off points described in  FIG. 25  divided the space between the LPSs of FL (×) and DLBCL/BL (+) samples. 
         FIG. 27 : Lymphoma classification results. Results of lymphoma classification based on gene expression. 100% of SLL, MCL, and FH samples were classified correctly, and only 3% of DLBCL/BL and FL samples were classified incorrectly. 
         FIG. 28 : DLBCL classification results. Results of DLBCL subtype classification based on gene expression. None of the ABC samples were classified as the wrong subtype, while only one of the BL samples was classified incorrectly. Of the GCB and PMBL samples, only 5% and 6%, respectively, were classified incorrectly. 
     
    
    
     DETAILED DESCRIPTION 
     The following description of the invention is merely intended to illustrate various embodiments of the invention. As such, the specific modifications discussed are not to be construed as limitations on the scope of the invention. It will be apparent to one skilled in the art that various equivalents, changes, and modifications may be made without departing from the scope of the invention, and it us understood that such equivalent embodiments are to be included herein. 
     Gene expression profiling of a cancer cell or biopsy reflects the molecular phenotype of a cancer at the time of diagnosis. As a consequence, the detailed picture provided by the genomic expression pattern provides the basis for a new systematic classification of cancers and more accurate predictors of survival and response to treatment. The present invention discloses methods for identifying, diagnosing, and/or classifying a lymphoma, lymphoid malignancy, or lymphoproliferative disorder based on its gene expression patterns. The present invention also discloses methods for predicting survival in a subject diagnosed with a particular lymphoma type or subtype using gene expression data. The information obtained using these methods will be useful in evaluating the optimal therapeutic approach to be employed with regards to a particular subject. 
     The term “lymphoproliferative disorder” as used herein refers to any tumor of lymphocytes, and may refer to both malignant and benign tumors. The terms “lymphoma” and “lymphoid malignancy” as used herein refer specifically to malignant tumors derived from lymphocytes and lymphoblasts. Examples of lymphomas include, but are not limited to, follicular lymphoma (FL), Burkitt lymphoma (BL), mantle cell lymphoma (MCL), follicular hyperplasia (FH), small cell lymphocytic lymphoma (SLL), mucosa-associated lymphoid tissue lymphoma (MALT), splenic lymphoma, multiple myeloma, lymphoplasmacytic lymphoma, post-transplant lymphoproliferative disorder (PTLD), lymphoblastic lymphoma, nodal marginal zone lymphoma (NMZ), germinal center B cell-like diffuse large B cell lymphoma (GCB), activated B cell-like diffuse large B cell lymphoma (ABC) and primary mediastinal B cell lymphoma (PMBL). 
     The phrase “lymphoma type” (or simply “type”) as used herein refers to a diagnostic classification of a lymphoma. The phrase may refer to a broad lymphoma class (e.g., DLBCL, FL, MCL, etc.) or to a subtype or subgroup falling within a broad lymphoma class (e.g., GCB DLBCL, ABC DLBCL). 
     The phrase “gene expression data” as used herein refers to information regarding the relative or absolute level of expression of a gene or set of genes in a cell or group of cells. The level of expression of a gene may be determined based on the level of RNA, such as mRNA, encoded by the gene. Alternatively, the level of expression may be determined based on the level of a polypeptide or fragment thereof encoded by the gene. “Gene expression data” may be acquired for an individual cell, or for a group of cells such as a tumor or biopsy sample. 
     The term “microarray,” “array,” or “chip” refers to a plurality of nucleic acid probes coupled to the surface of a substrate in different known locations. The substrate is preferably solid. Microarrays have been generally described in the art in, for example, U.S. Pat. No. 5,143,854 (Pirrung), U.S. Pat. No. 5,424,186 (Fodor), U.S. Pat. No. 5,445,934 (Fodor), U.S. Pat. No. 5,677,195 (Winkler), U.S. Pat. No. 5,744,305 (Fodor), U.S. Pat. No. 5,800,992 (Fodor), U.S. Pat. No. 6,040,193 (Winkler), and Fodor et al. 1991. Light-directed, spatially addressable parallel chemical synthesis. Science, 251:767-777. Each of these references is incorporated by reference herein in their entirety. 
     The term “gene expression signature” or “signature” as used herein refers to a group of coordinately expressed genes. The genes making up this signature may be expressed in a specific cell lineage, stage of differentiation, or during a particular biological response. The genes can reflect biological aspects of the tumors in which they are expressed, such as the cell of origin of the cancer, the nature of the non-malignant cells in the biopsy, and the oncogenic mechanisms responsible for the cancer (Shaffer 2001). Examples of gene expression signatures include lymph node (Shaffer 2001), proliferation (Rosenwald 2002), MHC class II, ABC DLBCL high, B-cell differentiation, T-cell, macrophage, immune response-1, immune response-2, and germinal center B cell. 
     The phrase “survival predictor score” as used herein refers to a score generated by a multivariate model used to predict survival based on gene expression. A subject with a higher survival predictor score is predicted to have poorer survival than a subject with a lower survival predictor score. 
     The term “survival” as used herein may refer to the probability or likelihood of a subject surviving for a particular period of time. Alternatively, it may refer to the likely term of survival for a subject, such as expected mean or median survival time for a subject with a particular gene expression pattern. 
     The phrase “linear predictor score” or “LPS” as used herein refers to a score that denotes the probability that a sample belongs to a particular lymphoma type. An LPS may be calculated using an equation such as: 
                 LPS   ⁡     (   S   )       =       ∑     j   ∈   G       ⁢       t   j     ⁢     S   j           ,         
where S j  is the expression of gene j from gene set G in a sample S, and t j  is a scale factor representing the difference in expression of gene j between a first lymphoma type and a second lymphoma type. Alternatively, a linear predictor score may be generated by other methods including but not limited to linear discriminant analysis (Dudoit 2002), support vector machines (Furey 2000), or shrunken centroids (Tibshirani 2002)
 
     The phrase “scale factor” as used herein refers to a factor that defines the relative difference in expression of a particular gene between two samples. An example of a scale factor is a t-score generated by a Student&#39;s t-test. 
     The phrase “lymphoma subject,” wherein “lymphoma” is a specific lymphoma type (e.g., “follicular lymphoma subject”), may refer to a subject that has been diagnosed with a particular lymphoma by any method known in the art or discussed herein. This phrase may also refer to a subject with a known or suspected predisposition or risk of developing a particular lymphoma type. 
     The pattern of expression of a particular gene is closely connected to the biological role and effect of its gene product. For this reason, the systematic study of variations in gene expression provides an alternative approach for linking specific genes with specific diseases and for recognizing heritable gene variations that are important for immune function. For example, allelic differences in the regulatory region of a gene may influence the expression levels of that gene. An appreciation for such quantitative traits in the immune system may help elucidate the genetics of autoimmune diseases and lymphoproliferative disorders. 
     Genes that encode components of the same multi-subunit protein complex are often coordinately regulated. Coordinate regulation is also observed among genes whose products function in a common differentiation program or in the same physiological response pathway. Recent application of gene expression profiling to the immune system has shown that lymphocyte differentiation and activation are accompanied by parallel changes in expression among hundreds of genes. Gene expression databases may be used to interpret the pathological changes in gene expression that accompany autoimmunity, immune deficiencies, cancers of immune cells and of normal immune responses. 
     Scanning and interpreting large bodies of relative gene expression data is a formidable task. This task is greatly facilitated by algorithms designed to organize the data in a way that highlights systematic features, and by visualization tools that represent the differential expression of each gene as varying intensities and hues of color (Eisen 1998). The development of microarrays, which are capable of generating massive amounts of expression data in a single experiment, has greatly increased the need for faster and more efficient methods of analyzing large-scale expression data sets. In order to effectively utilize microarray gene expression data for the identification and diagnosis of lymphoma and for the prediction of survival in lymphoma patients, new algorithms must be developed to identify important information and convert it to a more manageable format. In addition, the microarrays used to generate this data should be streamlined to incorporate probe sets that are useful for diagnosis and survival prediction. Embodiments of the present invention disclose methods and compositions that address both of these considerations. 
     The mathematical analysis of gene expression data is a rapidly evolving science based on a rich mathematics of pattern recognition developed in other contexts (Kohonen 1997). Mathematical analysis of gene expression generally has three goals. First, it may be used to identify groups of genes that are coordinately regulated within a biological system. Second, it may be used to recognize and interpret similarities between biological samples on the basis of similarities in gene expression patterns. Third, it may be used to recognize and identify those features of a gene expression pattern that are related to distinct biological processes or phenotypes. 
     Mathematical analysis of gene expression data often begins by establishing the expression pattern for each gene on an array across n experimental samples. The expression pattern of each gene can be represented by a point in n-dimensional space, with each coordinate specified by an expression measurement in one of the n samples (Eisen 1998). A clustering algorithm that uses distance metrics can then be applied to locate clusters of genes in this n-dimensional space. These clusters indicate genes with similar patterns of variation in expression over a series of experiments. Clustering methods that have been applied to microarray data in the past include hierarchical clustering (Eisen 1998), self-organizing maps (SOMs) (Tamayo 1999), k-means (Tavazoie 1999), and deterministic annealing (Alon 1999). A variety of different algorithms, each emphasizing distinct orderly features of the data, may be required to glean the maximal biological insight from a set of samples (Alizadeh 1998). One such algorithm, hierarchical clustering, begins by determining the gene expression correlation coefficients for each pair of the n genes studied. Genes with similar gene expression correlation coefficients are grouped next to one another in a hierarchical fashion. Generally, genes with similar expression patterns under a particular set of conditions encode protein products that play related roles in the physiological adaptation to those conditions. Novel genes of unknown function that are clustered with a large group of functionally related genes are likely to participate in the same biological process. Likewise, the other clustering methods mentioned herein may also group genes together that encode proteins with related biological function. 
     Gene expression maps may be constructed by organizing the gene expression data from multiple samples using any of the various clustering algorithms outlined herein. The ordered tables of data may then be displayed graphically in a way that allows researchers and clinicians to assimilate both the choreography of gene expression on a broad scale and the fine distinctions in expression of individual genes. 
     In such a gene expression map, genes that are clustered together reflect a particular biological function, and are termed gene expression signatures (Shaffer 2001). One general type of gene expression signature includes genes that are characteristically expressed in a particular cell type or at a particular stage of cellular differentiation or activation. Another general type of gene expression signature includes genes that are regulated in their expression by a particular biological process such as proliferation, or by the activity of a particular transcription factor or signaling pathway. 
     The pattern of gene expression in a biological sample provides a distinctive and accessible molecular picture of its functional state and identity (DeRisi 1997; Cho 1998; Chu 1998; Holstege 1998; Spellman 1998). Each cell transduces variation in its environment, internal state, and developmental state into readily measured and recognizable variation in gene expression patterns. Two different samples that have related gene expression patterns are therefore likely to be biologically and functionally similar to one another. Some biological processes are reflected by the expression of genes in a gene expression signature, as described above. The expression of gene expression signatures in a particular sample can provide important biological insights regarding its cellular composition and the function of various intracellular pathways within the cells. 
     The present invention discloses a variety of gene expression signatures related to the clinical outcome of lymphoma patients. While several of these signatures share a name with a previously disclosed signature, each of the gene expression signatures disclosed herein comprises a novel combination of genes. For example, the lymph node signature disclosed herein includes genes encoding extracellular matrix components and genes that are characteristically expressed in macrophage, NK, and T cells (e.g., α-Actinin, collagen type III α 1, connective tissue growth factor, fibronectin, KIAA0233, urokinase plasminogen activator). The proliferation signature includes genes that are characteristically expressed by cells that are rapidly multiplying or proliferating (e.g., c-myc, E21G3, NPM3, BMP6). The MHC class II signature includes genes that interact with lymphocytes in order to allow the recognition of foreign antigens (e.g., HLA-DPα, HLA-DQα, HLA-DRα, HLA-DRβ). The immune response-1 signature includes genes encoding T cell markers (e.g., CD7, CD8B1, ITK, LEF1, STAT4), as well as genes that are highly expressed in macrophages (e.g., ACTN1, TNFSF13B). The immune response-2 signature includes genes known to be preferentially expressed in macrophages and/or dendritic cells (e.g., TLR5, FCGR1A, SEPT10, LGMN, C3AR1). The germinal center B cell signature includes genes known to be overexpressed at this stage of B cell differentiation (e.g., MME, MEF2C, BCL6, LMO2, PRSPAP2, MBD4, EBF, MYBL1. 
     Databases of gene expression signatures have proven quite useful in elucidating the complex gene expression patterns of various cancers. For example, expression of genes from the germinal center B-cell signature in a lymphoma biopsy suggests that the lymphoma is derived from this stage of B cell differentiation. In the same lymphoma-biopsy, the expression of genes from the T cell signature can be used to estimate the degree of infiltration of the tumor by host T cells, while the expression of genes from the proliferation signature can be used to quantitate the tumor cell proliferation rate. In this manner, gene expression signatures provide an “executive summary” of the biological properties of a tumor specimen. Gene expression signatures can also be helpful in interpreting the results of a supervised analysis of gene expression data. Supervised analysis generates a long list of genes with expression patterns that are correlated with survival. Gene expression signatures can be useful in assigning these “predictive” genes to functional categories. In building a multivariate model of survival based on gene expression data, this functional categorization helps to limit the inclusion of multiple genes in the model that measure the same aspect of tumor biology. 
     Gene expression profiles can be used to create multivariate models for predicting survival. The methods for creating these models are called “supervised” because they use clinical data to guide the selection of genes to be used in the prognostic classification. For example, a supervised method might identify genes with expression patterns that correlate with the length of overall survival following chemotherapy. The general method used to create a multivariate model for predicting survival may utilize the following steps:
         1. Identify genes with expression patterns that are univariately associated with a particular clinical outcome using a Cox proportional hazards model. Generally, a univariate p-value of &lt;0.01 is considered the cut-off for significance. These genes are termed “predictor” genes.   2. Within a set of predictor genes, identify gene expression signatures.   3. For each gene expression signature that is significantly associated with survival, average the expression of the component genes within this signature to generate a gene expression signature value.   4. Build a multivariate Cox model of clinical outcome using the gene expression signature values.   5. If possible, include additional genes in the model that do not belong to a gene expression signature but which add to the statistical power of the model.
 
This approach has been utilized in the present invention to create novel survival prediction models for FL, DLBCL, and MCL. Each of these models generates a survival predictor score, with a higher score being associated with worse clinical outcome. Each of these models may be used separately to predict survival. Alternatively, these models may be used in conjunction with one or more other models, disclosed herein or in other references, to predict survival.
       

     A first FL survival predictor was generated using gene expression data obtained using Affymetrix U133A and U133B microarrays. This predictor incorporated immune response-1 and immune response-2 gene expression signatures. Fitting the Cox proportional hazards model to the gene expression signature values obtained from these signatures resulted in the following model:
 
Survival predictor score=[(2.71*immune response-2 gene expression signature value)]−[(2.36×immune response-1 gene expression signature value)].
 
     A second FL survival predictor was generated using gene expression data obtained using Affymetrix U133A and U133B microarrays. This predictor incorporated macrophage, T-cell, and B-cell differentiation gene expression signatures. Fitting the Cox proportional hazards model to the gene expression signature values obtained from these signatures resulted in the following model:
 
Survival predictor score=[2.053*(macrophage gene expression signature value)]−[2.344*(T-cell gene expression signature value)]−[0.729*(B-cell differentiation gene expression signature value)].
 
     A third FL survival predictor was generated using gene expression data obtained using the Lymph Dx microarray. This predictor incorporated macrophage, T-cell, and B-cell differentiation gene expression signatures. Fitting the Cox proportional hazards model to the gene expression signature values obtained from these signatures resulted in the following model:
 
Survival predictor score=[1.51*(macrophage gene expression signature value)]−[2.11*(T-cell gene expression signature value)]−[0.505*(B-cell differentiation gene expression signature value)].
 
     A first DLBCL survival predictor was generated using gene expression data obtained using Affymetrix U133A and U133B microarrays. This predictor incorporated ABC DLBCL high, lymph node, and MHC class II gene expression signatures. Fitting the Cox proportional hazards model to the gene expression signature values obtained from these signatures resulted in the following model:
 
Survival predictor score=[0.586*(ABC DLBCL high gene expression signature value)]−[0.468*(lymph node gene expression signature value)]−[0.336*(MHC class II gene expression signature value)].
 
     A second DLBCL survival predictor was generated using gene expression data obtained using the Lymph Dx microarray. This predictor incorporated lymph node, proliferation, germinal center B-cell, and MHC class II gene expression signatures. Fitting the Cox proportional hazards model to the gene expression signature values obtained from these signatures resulted in the following model:
 
Survival predictor score=[−0.4337*(lymph node gene expression signature value)]+[0.09*(proliferation gene expression signature value)]−[0.4144*(germinal center B-cell gene expression signature value)]−[0.2006*(MHC class II gene expression signature value)].
 
     A third DLBCL survival predictor was generated using gene expression data obtained using the Lymph Dx microarray. This predictor incorporated lymph node, germinal center B cell, and MHC class II gene expression signatures. Fitting the Cox proportional hazards model to the gene expression signature values obtained from these signatures resulted in the following model:
 
Survival predictor score=[−0.32*(lymph node gene expression signature value)]−[0.176*(germinal center B-cell gene expression signature value)]−[0.206*(MHC class II gene expression signature value)].
 
     An MCL survival predictor was generated using gene expression data obtained using Affymetrix U133A, Affymetrix U133B, and Lymph Dx microarrays. This predictor incorporated a proliferation gene expression signature. Fitting the Cox proportional hazards model to the gene expression signature values obtained from these signatures resulted in the following model:
 
Survival predictor score=[1.66*(proliferation gene expression signature value)].
 
     Gene expression data can also be used to diagnose and identify lymphoma types. In an embodiment of the present invention, a statistical method based on Bayesian analysis was developed to classify lymphoma specimens according to their gene expression profiles. This method does not merely assign a tumor to a particular lymphoma type, but also determines the probability that the tumor belongs to that lymphoma type. Many different methods have been formulated to predict cancer subgroups (Golub 1999; Ramaswamy 2001; Dudoit 2002; Radmacher 2002). These methods assign tumors to one of two subgroups based on expression of a set of differentially expressed genes. However, they do not provide a probability of membership in a subgroup. By contrast, the method disclosed herein used Bayes&#39; rule to estimate this probability, thus allowing one to vary the probability cut-off for assignment of a tumor to a particular subgroup. In tumor types in which unknown additional subgroups may exist, the present method allows samples that do not meet the gene expression criteria of known subgroups to fall into an unclassified group with intermediate probability. A cancer subgroup predictor of the type described herein may be used clinically to provide quantitative diagnostic information for an individual cancer patient. This information can in turn be used to provide a predictor of treatment outcome for a particular cancer patient. 
     For any two lymphoma types A and B, there is a set of genes with significantly higher expression in type A than type B, and a set of genes with significantly lower expression in type A than in type B. By observing the expression of these genes in an unknown sample, it is possible to determine to which of the two types the sample belongs. Evaluating the likelihood that a particular sample belongs to one or the other lymphoma type by Bayesian analysis may be done using the following steps:
         1) Identify those genes that are most differentially expressed between the two lymphoma types. This can be done by selecting those genes with the largest t-statistic between the two lymphoma types. The genes in this step may be subdivided into gene expression signatures in certain cases, with genes from each signature analyzed separately.   2) Create a series of linear predictor score (LPS) for samples belonging to either lymphoma type.   3) Evaluate the LPS for each sample in a training set, and estimate the distribution of these scores within each lymphoma type according to a normal distribution.   4) Use Bayes&#39; rule to evaluate the probability that each subsequent sample belongs to one or the other lymphoma type.
 
If only two types of lymphoma are being distinguished, then a single probability score is sufficient to discriminate between the two types. However, if more than two lymphoma types are being distinguished, multiple scores will be needed to highlight specific differences between the types.
       

     In an embodiment of the present invention, a novel microarray entitled the Lymph Dx microarray was developed for the identification and diagnosis of lymphoma types. The Lymph Dx microarray contains cDNA probes corresponding to approximately 2,653 genes, fewer than the number seen on microarrays that have been used previously for lymphoma diagnosis. The reduced number of probes on the Lymph Dx microarray is the result of eliminating genes that are less useful for the identification of lymphoma types and predicting clinical outcome. This reduction allows for simplified analysis of gene expression data. The genes represented on the Lymph Dx microarray can be divided into four broad categories: 1,101 lymphoma predictor genes identified previously using the Affymetrix U133 microarray, 171 outcome predictor genes, 167 new genes not found on the Affymetrix U133 microarray, and 1,121 named genes. A list of the probe sets on the Lymph Dx microarray is presented in Table 2, contained in the file “Table — 0002_LymphDx_Probe_List.txt.” 
     In an embodiment of the present invention, gene expression data obtained using the Lymph Dx microarray was used to identify and classify lymphomas using Bayesian analysis. This method was similar to that outlined above, but included additional steps designed to optimize the number of genes used and the cut-off points between lymphoma types. A general overview of this method is presented in  FIG. 1 . Each gene represented on the Lymph Dx microarray was placed into one of three gene-list categories based on its correlation with the lymph node or proliferation gene expression signatures: lymph node, proliferation, or standard. These signatures were identified by clustering of the DLBCL cases using hierarchical clustering and centroid-correlation of 0.35. Standard genes were those with expression patterns that did not correlate highly with expression of the lymph node or proliferation signatures. Lymph Dx gene expression data was first used to identify samples as FL, MCL, SLL, FH, or DLBCL/BL, then to identify DLBCL/BL samples as ABC, GCB, PMBL, or BL. For each stage, a series of pair-wise models was created, with each model containing a different pair of lymphoma types (e.g., FL vs. MCL, SLL vs. FH, etc.). For each pair, the difference in expression of each gene on the microarray was measured, and a t-statistic was generated representing this difference. Genes from each gene-list category were ordered based on their t-statistic, and those with the largest t-statistics were used to generate a series of LPSs for samples belonging to either lymphoma type. The number of genes used to generate the LPSs was optimized by repeating the calculation using between five and 100 genes from each gene-list category. The number of genes from each category used in the final LPS calculation was that which gave rise to the largest difference in LPS between the two lymphoma types. Once the number of genes in each gene-list category was optimized, four different LPSs were calculated for each sample. The first included genes from the standard gene-list category only, the second included genes from the proliferation and standard gene-list categories, the third included genes from the lymph node and standard gene-list categories, and the fourth included genes from all three categories. The probability q that a sample X belongs to the first lymphoma type of a pair-wise model can then be calculated using an equation: 
             q   =       ϕ   ⁡     (         LPS   ⁡     (   X   )       ;       μ   ^     1       ,       σ   ^     1       )           ϕ   ⁡     (         LPS   ⁡     (   X   )       ;       μ   ^     1       ,       σ   ^     1       )       +     ϕ   ⁡     (         LPS   ⁡     (   X   )       ;       μ   ^     2       ,       σ   ^     2       )                 
LPS(X) is the LPS for sample X, φ(x; μ, σ) is the normal density function with mean μ and standard deviation σ, {circumflex over (μ)} 1  and {circumflex over (σ)} 1  are the mean and variance of the LPSs for samples belonging to the first lymphoma type, and {circumflex over (μ)} 2  and {circumflex over (σ)} 2  are the mean and variance of the LPSs for samples belonging to the second lymphoma type. Samples with high q values were classified as the first lymphoma type, samples with low q values were classified as the second lymphoma type, and samples with middle range q values were deemed unclassified. To determine the proper cut-off point between high, low, and middle q values, every possible cut-off point between adjacent samples was analyzed by an equation:
 3.99*[(% of type 1 misidentified as type 2)+(% of type 2 misidentified as type 1)]+[(% of type 1 unclassified)+(% of type 2 misidentified)]. 
This equation was used to favor the assignment of a sample to an “unclassified” category rather than to an incorrect lymphoma type. The final cut-off points were those which minimized this equation. The coefficient of 3.99 was chosen arbitrarily to allow an additional classification error only if the adjustment resulted in four or more unclassified samples becoming correctly classified. The coefficient can be varied to achieve a different set of trade-offs between the number of unclassified and misidentified samples.
 
     To ensure that the accuracy of the model was not a result of overfitting, each model was validated by leave-one-out cross-validation. This entailed removing each sample of known lymphoma type from the data one at a time, and then determining whether the model could predict the missing sample. This process confirmed the accuracy of the prediction method. 
     The classification of a lymphoproliferative disorder in accordance with embodiments of the present invention may be used in combination with any other effective classification feature or set of features. For example, a disorder may be classified by a method of the present invention in conjunction with WHO suggested guidelines, morphological properties, histochemical properties, chromosomal structure, genetic mutation, cellular proliferation rates, immunoreactivity, clinical presentation, and/or response to chemical, biological, or other agents. Embodiments of the present invention may be used in lieu of or in conjunction with other methods for lymphoma diagnosis, such as immunohistochemistry, flow cytometry, FISH for translocations, or viral diagnostics. 
     Accurate determination of lymphoma type in a subject allows for better selection and application of therapeutic methods. Knowledge about the exact lymphoma affecting a subject allows a clinician to select therapies or treatments that are most appropriate and useful for that subject, while avoiding therapies that are nonproductive or even counterproductive. For example, CNS prophylaxis may be useful for treating BL but not DLBCL, CHOP treatment may be useful for treating DLBCL but not blastic MCL (Fisher 1993; Khouri 1998), and subjects with follicular lymphoma frequently receive treatment while subjects with follicular hyperplasia do not. In each of these situations, the lymphoma types or subtypes in question can be difficult to distinguish using prior art diagnostic methods. The diagnostic and identification methods of the present invention allow for more precise delineation between these lymphomas, which simplifies the decision of whether to pursue a particular therapeutic option. Likewise, the survival prediction methods disclosed in the present invention also allow for better selection of therapeutic options. A subject with a very low survival predictor score (i.e., very good prognosis) may not receive treatment, but may instead be subjected to periodic check-ups and diligent observation. As survival predictor scores increase (i.e., prognosis gets worse), subjects may receive more intensive treatments. Those subjects with the highest survival predictor scores (i.e., very poor prognosis) may receive experimental treatments or treatments with novel agents. Accurate survival prediction using the methods disclosed herein provides an improved tool for selecting treatment options and for predicting the likely clinical outcome of those options. 
     Any effective method of quantifying the expression of at least one gene, gene set, or group of gene sets may be used to acquire gene expression data for use in embodiments of the present invention. For example, gene expression data may be measured or estimated using one or more microarrays. The microarrays may be of any effective type, including but not limited to nucleic acid based or antibody based. Gene expression may also be measured by a variety of other techniques, including but not limited to PCR, quantitative RT-PCR, real-time PCR, RNA amplification, in situ hybridization, immunohistochemistry, immunocytochemistry, FACS, serial analysis of gene expression (SAGE) (Velculescu 1995), Northern blot hybridization, or western blot hybridization. 
     Nucleic acid microarrays generally comprise nucleic acid probes derived from individual genes and placed in an ordered array on a support. This support may be, for example, a glass slide, a nylon membrane, or a silicon wafer. Gene expression patterns in a sample are obtained by hybridizing the microarray with the gene expression product from the sample. This gene expression product may be, for example, total cellular mRNA, rRNA, or cDNA obtained by reverse transcription of total cellular mRNA. The gene expression product from a sample is labeled with a radioactive, fluorescent, or other label to allow for detection. Following hybridization, the microarray is washed, and hybridization of gene expression product to each nucleic acid probe on the microarray is detected and quantified using a detection device such as a phosphorimager or scanning confocal microscope. 
     There are two broad classes of microarrays: cDNA and oligonucleotide arrays. cDNA arrays consist of hundreds or thousands of cDNA probes immobilized on a solid support. These cDNA probes are usually 100 nucleotides or greater in size. There are two commonly used designs for cDNA arrays. The first is the nitrocellulose filter array, which is generally prepared by robotic spotting of purified DNA fragments or lysates of bacteria containing cDNA clones onto a nitrocellulose filter (Southern 1992; Southern 1994; Gress 1996; Pietu 1996). The other commonly used cDNA arrays is fabricated by robotic spotting of PCR fragments from cDNA clones onto glass microscope slides (Schena 1995; DeRisi 1996; Schena 1996; Shalon 1996; DeRisi 1997; Heller 1997; Lashkari 1997). These cDNA microarrays are simultaneously hybridized with two fluorescent cDNA probes, each labeled with a different fluorescent dye (typically Cy3 or Cy5). In this format, the relative mRNA expression in two samples is directly compared for each gene on the microarray. Oligonucleotide arrays differ from cDNA arrays in that the probes are 20- to 25-mer oligonucleotides. Oligonucleotide arrays are generally produced by in situ oligonucleotide synthesis in conjunction with photolithographic masking techniques (Pease 1994; Lipshutz 1995; Chee 1996; Lockhart 1996; Wodicka 1997). The solid support for oligonucleotide arrays is typically a glass or silicon surface. 
     Methods and techniques applicable to array synthesis and use have been described in, for example, U.S. Pat. No. 5,143,854 (Pirrung), U.S. Pat. No. 5,242,974 (Holmes), U.S. Pat. No. 5,252,743 (Barrett), U.S. Pat. No. 5,324,633 (Fodor), U.S. Pat. No. 5,384,261 (Winkler), U.S. Pat. No. 5,424,186 (Fodor), U.S. Pat. No. 5,445,934 (Fodor), U.S. Pat. No. 5,451,683 (Barrett), U.S. Pat. No. 5,482,867 (Barrett), U.S. Pat. No. 5,491,074 (Aldwin), U.S. Pat. No. 5,527,681 (Holmes), U.S. Pat. No. 5,550,215 (Holmes), U.S. Pat. No. 5,571,639 (Hubbell), U.S. Pat. No. 5,578,832 (Trulson), U.S. Pat. No. 5,593,839 (Hubbell), U.S. Pat. No. 5,599,695 (Pease), U.S. Pat. No. 5,624,711 (Sundberg), U.S. Pat. No. 5,631,734 (Stern), U.S. Pat. No. 5,795,716 (Chee), U.S. Pat. No. 5,831,070 (Pease), U.S. Pat. No. 5,837,832 (Chee), U.S. Pat. No. 5,856,101 (Hubbell), U.S. Pat. No. 5,858,659 (Sapolsky), U.S. Pat. No. 5,936,324 (Montagu), U.S. Pat. No. 5,968,740 (Fodor), U.S. Pat. No. 5,974,164 (Chee), U.S. Pat. No. 5,981,185 (Matson), U.S. Pat. No. 5,981,956 (Stern), U.S. Pat. No. 6,025,601 (Trulson), U.S. Pat. No. 6,033,860 (Lockhart), U.S. Pat. No. 6,040,193 (Winkler), U.S. Pat. No. 6,090,555 (Fiekowsky), and U.S. Pat. No. 6,410,229 (Lockhart), and U.S. Patent Application Publication No. 20030104411 (Fodor). Each of the above patents and applications is incorporated by reference herein in its entirety. 
     Microarrays may generally be produced using a variety of techniques, such as mechanical or light directed synthesis methods that incorporate a combination of photolithographic methods and solid phase synthesis methods. Techniques for the synthesis of microarrays using mechanical synthesis methods are described in, for example, U.S. Pat. No. 5,384,261 (Winkler) and U.S. Pat. No. 6,040,193 (Winkler). Although a planar array surface is preferred, the microarray may be fabricated on a surface of virtually any shape, or even on a multiplicity of surfaces. Microarrays may be nucleic acids on beads, gels, polymeric surfaces, fibers such as fiber optics, glass or any other appropriate substrate. See, for example, U.S. Pat. No. 5,708,153 (Dower); U.S. Pat. No. 5,770,358 (Dower); U.S. Pat. No. 5,789,162 (Dower); U.S. Pat. No. 5,800,992 (Fodor); and U.S. Pat. No. 6,040,193 (Winkler), each of which is incorporated by reference herein in its entirety. 
     Microarrays may be packaged in such a manner as to allow for diagnostic use, or they can be an all-inclusive device. See, for example, U.S. Pat. No. 5,856,174 (Lipshutz) and U.S. Pat. No. 5,922,591 (Anderson), both of which are incorporated by reference herein in their entirety. 
     Microarrays directed to a variety of purposes are commercially available from Affymetrix (Affymetrix, Santa Clara, Calif.). For instance, these microarrays may be used for genotyping and gene expression monitoring for a variety of eukaryotic and prokaryotic species. 
     The following examples are provided to better illustrate the claimed invention and are not to be interpreted as limiting the scope of the invention. To the extent that specific materials are mentioned, it is merely for purposes of illustration and is not intended to limit the invention. One skilled in the art may develop equivalent means or reactants without the exercise of inventive capacity and without departing from the scope of the invention. It will be understood that many variations can be made in the procedures herein described while still remaining within the bounds of the present invention. It is the intention of the inventors that such variations are included within the scope of the invention. 
     EXAMPLES 
     Example 1 
     Collection and Analysis of Gene Expression Data Using Affymetrix U133A and U133B Microarrays 
     568 cell samples representing various forms of human lymphoid malignancies were obtained by biopsy using known methods described in the literature. The samples were reviewed by a panel of hematopathologists and classified into the following lymphoma types based on current diagnostic criteria:
         231 diffuse large B cell lymphomas (DLBCL)   191 follicular lymphomas (FL)   26 Burkitt lymphomas (BL)   21 mantle cell lymphoma (MCL)   18 follicular hyperplasias (FH)   17 small cell lymphocytic lymphomas (SLL)   16 mucosa-associated lymphoid tissue lymphomas (MALT)   13 splenic lymphomas (Splenic)   10 cyclin-D1 negative lymphomas with MCL morphology (CD1negMCL)   9 multiple myeloma (Mult_Myeloma)   6 lymphoplasmacytic lymphomas (LPC)   4 post-transplant lymphoproliferative disorders (PTLD)   3 lymphoblastic lymphomas (Lymbl)   3 nodal marginal zone lymphomas (NMZ)
 
The 231 DLBCL samples were subdivided into the following lymphoma types based on gene expression (see below):
   88 germinal center B cell-like (GCB)   78 activated B cell-like (ABC)   33 primary mediastinal B cell lymphoma (PMBL)   32 samples for which the subtype could not be determined (UC_DLBCL)
 
The 16 MALT samples were subdivided into the following four group based on tumor origin:
   9 from the gastric region (MALT_gastric)   1 from the salivary gland (MALT_salivary)   1 from the lung (MALT_lung)   1 from the tonsil (MALT_tonsil)   4 of unknown origin (MALT_unk)       

     Each of the 568 cell samples was given a unique sample ID number consisting of the lymphoma type followed by a unique numerical identifier. For example, “ABC — 304” refers to an ABC DLBCL sample numbered 304. Cells were purified and RNA was isolated from the purified cells according to known methods described in the literature. 
     Aliquots of RNA from each sample were applied to Affymetrix U133A and Affymetrix U133B microarrays according to standard Affymetrix protocol. The U133A and U133B microarrays are divided into probe sets, with each probe set consisting of up to 69 oligonucleotide probes 25 nucleotides in length. Each probe set represents a distinct human gene. Information pertaining to these microarrays is available at the Affymetrix company web site. Each microarray was scanned using an Affymetrix scanner, which records signal intensity for every probe on the microarray. This information can be transformed into summary signal values for each probe set using a number of different algorithms, including MAS 5.0, D-chip (Li 2001), or Bioconductor&#39;s RMA algorithms (Irizarry 2003). The images produced by the scanner were evaluated by Affymetrix MAS 5.0 software and stored as tables in .txt format. Since each sample was scanned on both microarrays, there are two .txt files for each sample. Each .txt file was given a unique name consisting of the table number, sample ID number (discussed above), and a letter denoting the microarray used. For example, Table — 0588_ABC — 304_A.txt is the .txt file for Table 588, which contains data for sample ID number ABC — 304 from the U133A array. The data for each sample tested is contained in Tables 3-1138. 
     The signal value for each probe on the U133A and U133B microarrays was normalized to a target value of 500, and the base-2 log of the normalized values was used for the following analyses. Log-signal values for each probe set are presented in Tables 1139-1706, contained in files with the title format “Table_No._NAME_log_signal.txt,” where NAME refers to the sample ID number (e.g., ABC — 304). The first column provides the UNIQID for the probe set, while the second column provides the log-signal value. 
     Log-signal files were statistically analyzed using S+ software and the S+ subtype predictor script contained in the file entitled “Subtype_Predictor.txt,” located in the computer program listing appendix contained on CD number 22 of 22. Although the log-signal values were analyzed using S+ software and the above algorithm, any effective software/algorithm combination may be used. Tables 1707-1721 provide descriptive statistical characteristics for each of the lymphoma types tested except for CD1negMCL, non-gastric MALT, and UC_DLBCL. Table 1722 provides statistical characteristics for all MALT samples combined, while Table 1723 does likewise for all DLBCL samples. 
     The files containing Tables 1707-1723 have the title format “Table_No._TYPE_Stats.txt,” where TYPE refers to the lymphoma type. Each row of these tables represents a particular probe set. The first column of each table provides the UNIQID for the probe set, while the second column provides the average log-signal for the probe set over all samples of a particular lymphoma type. The third column provides the log-fold change in expression of the probe set between the lymphoma type in question and a second lymphoma type. For example, if logfold.ABC.vs.GCB is −0.21 for gene X, expression of gene X in the ABC DLBCL samples is, on average, 0.86 (i.e., 2 −0.21 ) times greater than expression of gene X in the GCB DLBCL samples. The fourth column provides a two-sided P-value derived from a t-test of the log signals of the two lymphoma types compared in column three. If, for example, P.value.ABC.vs.GCB was 0.00001 for gene X, this would indicate that the observed difference in expression of gene X between ABC DLBCL and GCB DLBCL would only occur approximately one time in 100,000 if there was no actual difference in gene X expression between the two lymphoma types. The remainder of the columns can be read as pairs that repeat the pattern of columns three and four, presenting the log-fold change and P-value of the difference in expression of the probe set for the lymphoma type in question versus all other lymphoma types being tested. Tables 1710, 1715, and 1723 (corresponding to FL, MCL, and DLBCL, respectively) contain two additional columns entitled “TYPE_Cox coefficient” and “TYPE_Cox_P_value.” The content of these columns is discussed in the following examples. 
     Example 2 
     Collection of Gene Expression Data Using the Novel Lymph Dx Microarray 
     The novel Lymph Dx microarray contains cDNA probes corresponding to approximately 2,734 genes. 174 of these are “housekeeping” genes present for quality control, since they represent genes that are most variably expressed across all lymphoma samples. Other genes represented on the microarray were selected for their utility in identifying particular lymphoma samples and predicting survival in those samples. The genes represented on the Lymph Dx microarray can be divided into four broad categories: 1,101 lymphoma predictor genes identified previously using the Affymetrix U133 microarray, 171 outcome predictor genes identified using the Affymetrix U133 microarray, 167 genes not found on the Affymetrix U133 microarray but represented on the Lymphochip microarray (Alizadeh 1999), and 1,121 named genes. The types of genes making up each of these broad categories are summarized in Table 1724, below, while the specific genes represented on the Lymph Dx microarray are listed in Table 2, contained in the file “Table — 0002_LymphDx_Probe_List.txt.” 
     
       
         
           
               
               
               
             
               
                   
                 TABLE 1724 
               
               
                   
                   
               
               
                   
                   
                 Number of 
               
               
                   
                 Gene type 
                 genes 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                 Lymphoma predictor genes 
                 1101 
               
               
                   
                 Subtype specific 
                 763 
               
               
                   
                 Lymph node signature 
                 178 
               
               
                   
                 Proliferation signature 
                 160 
               
               
                   
                 Outcome predictor genes 
                 171 
               
               
                   
                 DLBCL 
                 79 
               
               
                   
                 FL 
                 81 
               
               
                   
                 MCL 
                 11 
               
               
                   
                 New genes not on U133 
                 167 
               
               
                   
                 Lymphochip lymphoma predictor genes 
                 84 
               
               
                   
                 EBV and HHV8 viral genes 
                 18 
               
               
                   
                 BCL-2/cyclin D1/INK4a specialty probes 
                 14 
               
               
                   
                 Named genes missing from U133 
                 51 
               
               
                   
                 Named genes 
                 1121 
               
               
                   
                 Protein kinase 
                 440 
               
               
                   
                 Interleukin 
                 35 
               
               
                   
                 Interleukin receptor 
                 29 
               
               
                   
                 Chemokine 
                 51 
               
               
                   
                 Chemokine receptor 
                 29 
               
               
                   
                 TNF family 
                 26 
               
               
                   
                 TNF receptor family 
                 51 
               
               
                   
                 Adhesion 
                 45 
               
               
                   
                 Surface marker 
                 264 
               
               
                   
                 Oncogene/tumor suppressor 
                 49 
               
               
                   
                 Apoptosis 
                 46 
               
               
                   
                 Drug target 
                 10 
               
               
                   
                 Regulatory 
                 46 
               
               
                   
                   
               
            
           
         
       
     
     Cell samples representing various forms of human lymphoid malignancy were obtained by biopsy using known methods described in the literature. These 634 biopsy samples were reviewed by a panel of hematopathologists and classified into the following lymphoma types based on current diagnostic criteria:
         201 diffuse large B-cell lymphomas (DLBCL)   191 follicular lymphomas (FL)   60 Burkitt lymphomas (BL)   21 mantle cell lymphomas (MCL)   30 primary mediastinal B cell lymphoma (PMBL)   18 follicular hyperplasias (FH)   18 small cell lymphocytic lymphomas (SLL)   17 mucosa-associated lymphoid tissue lymphomas (MALT), including 9 gastric MALTs (GMALT)   16 chronic lymphocytic leukemias (CLL)   13 splenic lymphomas (SPL)   11 lymphoplasmacytic lymphomas (LPC)   11 transformed DLBCL (trDLBCL) (DLBCL that arose from an antecedent FL)   10 cyclin D1 negative lymphomas with MCL morphology (CD1N)   6 peripheral T-cell lymphoma (PTCL)   4 post-transplant lymphoproliferative disorders (PTLD)   4 nodal marginal zone lymphomas (NMZ)   3 lymphoblastic lymphomas (LBL)       

     Each of the 634 samples was given a unique sample ID number consisting of the lymphoma type followed by a unique numerical identifier. For example, “BL — 2032 — 52748” refers to a Burkitt lymphoma sample with the numerical identifier 2032 — 52748. Cells were purified and RNA was isolated from the purified cells according to known methods described in the literature. 
     Aliquots of purified RNA from each sample was applied to the Lymph Dx microarrays according to standard Affymetrix microarray protocol. Each microarray was scanned on an Affymetrix scanner. This scanner produced an image of the microarray, which was then evaluated by Affymetrix MAS 5.0 software. This information was stored in tables in .txt format. Each of these .txt files was given a unique name consisting of the table number, the sample ID number (discussed above), and the UNIQID for identifying the array data in the National Cancer Institute Database. For example, Table — 1725_BL — 2032 — 52748.txt is the .txt file for Table 1725, which contains data for sample ID number BL — 2032. The data for each sample analyzed is contained in Tables 1725-2358. The signal intensity for each probe on the microarray can be transformed into summary signal values for each probe set through a number of different algorithms, including but not limited to MAS 5.0, D-chip (Li 2001), or Bioconductor&#39;s RMA algorithms (Irizarry 2003). 
     Example 3 
     Development of a First FL Survival Predictor Using Gene Expression Data from Affymetrix U133A and U133B Microarrays 
     An analytical method entitled Survival Signature Analysis was developed to create survival prediction models for lymphoma. This method is summarized in  FIG. 2 . The key feature of this method is the identification of gene expression signatures. Survival Signature Analysis begins by identifying genes whose expression patterns are statistically associated with survival. A hierarchical clustering algorithm is then used to identify subsets of these genes with correlated expression patterns across the lymphoma samples. These subsets are operationally defined as “survival-associated signatures.” Evaluating a limited number of survival-associated signatures mitigates the multiple comparison problems that are inherent in the use of large-scale gene expression data sets to create statistical models of survival (Ransohoff 2004). 
     FL samples were divided into two equivalent groups: a training set (95 samples) for developing the survival prediction model, and a validation set (96 samples) for evaluating the reproducibility of the model. The overall survival of this cohort is depicted in  FIG. 3 . The median age at diagnosis was 51 years (ranging from 23 to 81 years), and the patients had a median follow-up of 6.6 years (8.1 years for survivors, with a range of &lt;1 to 28.2 years). Gene expression data from Affymetrix U133A and U133B microarrays was obtained for each sample. Within the training set, a Cox proportional hazards model was used to identify “survival predictor” genes, which were genes whose expression levels were associated with long survival (good prognosis genes) or short survival (poor prognosis genes). A hierarchical clustering algorithm (Eisen 1998) was used to identify gene expression signatures within the good and poor prognosis genes according to their expression pattern across all samples. Ten gene expression signatures were observed within either the good prognosis or poor prognosis gene sets ( FIG. 4 ). The expression level of every component gene in each of these ten gene expression signatures was averaged to create a gene expression signature value. 
     To create a multivariate model of survival, different combinations of the ten gene expression signature values were generated and evaluated for their ability to predict survival within the training set. Among models consisting of two signatures, an exceptionally strong statistical synergy was observed between one signature from the good prognosis group and one signature from the poor prognosis group. These signatures were deemed “immune response-1” and “immune response-2,” respectively; based on the biological function of certain genes within each signature. The immune response-1 gene expression signature included genes encoding T cell markers (e.g., CD7, CD8B1, ITK, LEF1, STAT4) and .genes that are highly expressed in macrophaqes (e.g., ACTN1, TNFSF13B). The immune response-1 signature is not merely a surrogate for the number of T cells in the FL biopsy sample because many other standard T cell genes (e.g., CD2, CD4, LAT, TRIM, SH2D1A) were not associated with survival. The immune response-2 gene expression signature included genes known to be preferentially expressed in macrophages and/or dendritic cells (e.g., TLR5, FCGR1A, SEPT10, LGMN, C3AR1). Table 2359 lists the genes that were used to generate the gene expression signature values for the immune response-1 and immune response-2 signatures. The Unigene ID Build database referenced in the following tables is hosted by the hosted by the National Center for Biotechnology Information (NCBI) web site. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 2359 
               
               
                   
               
               
                 Signature 
                 UNIQID 
                 Unigene ID Build 167 
                 Gene symbol 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 Immune response-1 
                 1095985 
                 83883 
                 TMEPAI 
               
               
                 Immune response-1 
                 1096579 
                 117339 
                 HCST 
               
               
                 Immune response-1 
                 1097255 
                 380144 
               
               
                 Immune response-1 
                 1097307 
                 379754 
                 LOC340061 
               
               
                 Immune response-1 
                 1097329 
                 528675 
                 TEAD1 
               
               
                 Immune response-1 
                 1097561 
                 19221 
                 C20orf112 
               
               
                 Immune response-1 
                 1098152 
                 377588 
                 KIAA1450 
               
               
                 Immune response-1 
                 1098405 
                 362807 
                 IL7R 
               
               
                 Immune response-1 
                 1098548 
                 436639 
                 NFIC 
               
               
                 Immune response-1 
                 1098893 
                 43577 
                 ATP8B2 
               
               
                 Immune response-1 
                 1099053 
                 376041 
               
               
                 Immune response-1 
                 1100871 
                 48353 
               
               
                 Immune response-1 
                 1101004 
                 2969 
                 SKI 
               
               
                 Immune response-1 
                 1103303 
                 49605 
                 C9orf52 
               
               
                 Immune response-1 
                 1107713 
                 171806 
               
               
                 Immune response-1 
                 1115194 
                 270737 
                 TNFSF13B 
               
               
                 Immune response-1 
                 1119251 
                 433941 
                 SEPW1 
               
               
                 Immune response-1 
                 1119838 
                 469951 
                 GNAQ 
               
               
                 Immune response-1 
                 1119924 
                 32309 
                 INPP1 
               
               
                 Immune response-1 
                 1120196 
                 173802 
                 TBC1D4 
               
               
                 Immune response-1 
                 1120267 
                 256278 
                 TNFRSF1B 
               
               
                 Immune response-1 
                 1121313 
                 290432 
                 HOXB2 
               
               
                 Immune response-1 
                 1121406 
                 NA 
                 TNFSF12 
               
               
                 Immune response-1 
                 1121720 
                 80642 
                 STAT4 
               
               
                 Immune response-1 
                 1122956 
                 113987 
                 LGALS2 
               
               
                 Immune response-1 
                 1123038 
                 119000 
                 ACTN1 
               
               
                 Immune response-1 
                 1123092 
                 437191 
                 PTRF 
               
               
                 Immune response-1 
                 1123875 
                 428 
                 FLT3LG 
               
               
                 Immune response-1 
                 1124760 
                 419149 
                 JAM3 
               
               
                 Immune response-1 
                 1128356 
                 415792 
                 C1RL 
               
               
                 Immune response-1 
                 1128395 
                 7188 
                 SEMA4C 
               
               
                 Immune response-1 
                 1132104 
                 173802 
                 TBC1D4 
               
               
                 Immune response-1 
                 1133408 
                 12802 
                 DDEF2 
               
               
                 Immune response-1 
                 1134069 
                 405667 
                 CD8B1 
               
               
                 Immune response-1 
                 1134751 
                 106185 
                 RALGDS 
               
               
                 Immune response-1 
                 1134945 
                 81897 
                 KIAA1128 
               
               
                 Immune response-1 
                 1135743 
                 299558 
                 TNFRSF25 
               
               
                 Immune response-1 
                 1135968 
                 119000 
                 ACTN1 
               
               
                 Immune response-1 
                 1136048 
                 299558 
                 TNFRSF25 
               
               
                 Immune response-1 
                 1136087 
                 211576 
                 ITK 
               
               
                 Immune response-1 
                 1137137 
                 195464 
                 FLNA 
               
               
                 Immune response-1 
                 1137289 
                 36972 
                 CD7 
               
               
                 Immune response-1 
                 1137534 
                 36972 
                 CD7 
               
               
                 Immune response-1 
                 1139339 
                 47099 
                 GALNT12 
               
               
                 Immune response-1 
                 1139461 
                 14770 
                 BIN2 
               
               
                 Immune response-1 
                 1140391 
                 44865 
                 LEF1 
               
               
                 Immune response-1 
                 1140524 
                 10784 
                 C6orf37 
               
               
                 Immune response-1 
                 1140759 
                 298530 
                 RAB27A 
               
               
                 Immune response-2 
                 1118755 
                 127826 
                 EPOR 
               
               
                 Immune response-2 
                 1118966 
                 19196 
                 LOC51619 
               
               
                 Immune response-2 
                 1121053 
                 1690 
                 FGFBP1 
               
               
                 Immune response-2 
                 1121267 
                 334629 
                 SLN 
               
               
                 Immune response-2 
                 1121331 
                 8980 
                 TESK2 
               
               
                 Immune response-2 
                 1121766 
                 396566 
                 MPP3 
               
               
                 Immune response-2 
                 1121852 
                 421391 
                 LECT1 
               
               
                 Immune response-2 
                 1122624 
                 126378 
                 ABCG4 
               
               
                 Immune response-2 
                 1122679 
                 232770 
                 ALOXE3 
               
               
                 Immune response-2 
                 1122770 
                 66578 
                 CRHR2 
               
               
                 Immune response-2 
                 1123767 
                 1309 
                 CD1A 
               
               
                 Immune response-2 
                 1123841 
                 389 
                 ADH7 
               
               
                 Immune response-2 
                 1126097 
                 498015 
               
               
                 Immune response-2 
                 1126380 
                 159408 
               
               
                 Immune response-2 
                 1126628 
                 254321 
                 CTNNA1 
               
               
                 Immune response-2 
                 1126836 
                 414410 
                 NEK1 
               
               
                 Immune response-2 
                 1127277 
                 121494 
                 SPAM1 
               
               
                 Immune response-2 
                 1127519 
                 NA 
               
               
                 Immune response-2 
                 1127648 
                 285050 
               
               
                 Immune response-2 
                 1128483 
                 444359 
                 SEMA4G 
               
               
                 Immune response-2 
                 1128818 
                 115830 
                 HS3ST2 
               
               
                 Immune response-2 
                 1129012 
                 95497 
                 SLC2A9 
               
               
                 Immune response-2 
                 1129582 
                 272236 
                 C21orf77 
               
               
                 Immune response-2 
                 1129658 
                 58356 
                 PGLYRP4 
               
               
                 Immune response-2 
                 1129705 
                 289368 
                 ADAM19 
               
               
                 Immune response-2 
                 1129867 
                 283963 
                 G6PC2 
               
               
                 Immune response-2 
                 1130003 
                 432799 
               
               
                 Immune response-2 
                 1130388 
                 19196 
                 LOC51619 
               
               
                 Immune response-2 
                 1131837 
                 156114 
                 PTPNS1 
               
               
                 Immune response-2 
                 1133843 
                 6682 
                 SLC7A11 
               
               
                 Immune response-2 
                 1133949 
                 502092 
                 PSG9 
               
               
                 Immune response-2 
                 1134447 
                 417628 
                 CRHR1 
               
               
                 Immune response-2 
                 1135117 
                 512646 
                 PSG6 
               
               
                 Immune response-2 
                 1136017 
                 1645 
                 CYP4A11 
               
               
                 Immune response-2 
                 1137478 
                 315235 
                 ALDOB 
               
               
                 Immune response-2 
                 1137745 
                 26776 
                 NTRK3 
               
               
                 Immune response-2 
                 1137768 
                 479985 
               
               
                 Immune response-2 
                 1138476 
                 351874 
                 HLA-DOA 
               
               
                 Immune response-2 
                 1138529 
                 407604 
                 CRSP2 
               
               
                 Immune response-2 
                 1138601 
                 149473 
                 PRSS7 
               
               
                 Immune response-2 
                 1139862 
                 251383 
                 CHST4 
               
               
                 Immune response-2 
                 1140189 
                 287369 
                 IL22 
               
               
                 Immune response-2 
                 1140389 
                 22116 
                 CDC14B 
               
               
                   
               
            
           
         
       
     
     Although the immune response-1 and immune response-2 gene expression signatures taken individually were not ideal predictors of survival, the binary model formed by combining the two was more predictive of survival in the training set than any other binary model (p&lt;0.001). Using this binary model as an anchor, other signatures were added to the model using a step up procedure (Drapner 1966). Of the remaining eight signatures, only one signature contributed significantly to the model in the training set (p&lt;0.01), resulting in a three-variable model for survival. This model was associated with survival in a highly statistically significant fashion in both the training (p&lt;0.001) and validation sets (p=0.003). However, only the immune response-1 and immune response-2 gene expression signatures contributed to the predictive power of the model in both the training set and the validation set. The predictive power of each of these signatures is summarized in Table 2360. 
                                 TABLE 2360                   Contribution of   Relative               signature   risk of death   Effect of           to model   among patients   increased       Gene expression   in validation set   in validation   expression       signature   (p-value)   set (95% C.I.)   on survival                  Immune response-1   &lt;0.001   0.15 (0.05-0.46)   Favorable       Immune response-2   &lt;0.001   9.35 (3.02-28.9)   Poor                    
Based on this information, the third signature was removed from the model and the two-signature model was used to generate a survival predictor score using the following equation:
 Survival predictor score=[(2.71*immune response-2 gene expression signature value)]−[(2.36×immune response-1 gene expression signature value)]. 
A higher survival predictor score was associated with worse outcome. The two-signature model was associated with survival in a statistically significant fashion in both the training set (p&lt;0.001) and the validation set (p&lt;0.001), which demonstrated that the model was reproducible. For the 187 FL samples with available clinical data, the survival predictor score had a mean of 1.6 and a standard deviation of 0.894, with each unit increase in the predictor score corresponding to a 2.5 fold increase in the relative risk of death. Data for all 191 samples is shown in Table 2361.
 
     
       
         
           
               
               
               
               
               
               
               
             
               
                 TABLE 2361 
               
               
                   
               
               
                   
                   
                 Length of 
                 Status 
                 Immune 
                 Immune 
                 Survival 
               
               
                 Sample 
                   
                 follow-up 
                 at 
                 response-1 
                 response-2 
                 predictor 
               
               
                 ID # 
                 Set 
                 (years) 
                 follow-up 
                 signature value 
                 signature value 
                 score 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 FL_1073 
                 Training 
                 7.68 
                 Dead 
                 9.20 
                 8.67 
                 1.77 
               
               
                 FL_1074 
                 Training 
                 4.52 
                 Dead 
                 9.10 
                 8.57 
                 1.74 
               
               
                 FL_1075 
                 Validation 
                 4.52 
                 Dead 
                 8.97 
                 8.69 
                 2.38 
               
               
                 FL_1076 
                 Training 
                 3.22 
                 Dead 
                 9.20 
                 8.55 
                 1.44 
               
               
                 FL_1077 
                 Training 
                 7.06 
                 Alive 
                 9.80 
                 8.46 
                 −0.20 
               
               
                 FL_1078 
                 Training 
                 4.95 
                 Alive 
                 9.32 
                 8.23 
                 0.30 
               
               
                 FL_1080 
                 Training 
                 6.05 
                 Alive 
                 9.45 
                 8.94 
                 1.93 
               
               
                 FL_1081 
                 Validation 
                 6.61 
                 Alive 
                 9.00 
                 8.22 
                 1.05 
               
               
                 FL_1083 
                 Training 
                 10.01 
                 Alive 
                 9.82 
                 8.72 
                 0.47 
               
               
                 FL_1085 
                 Validation 
                 8.84 
                 Alive 
                 9.31 
                 8.58 
                 1.29 
               
               
                 FL_1086 
                 Validation 
                 1.98 
                 Dead 
                 9.49 
                 9.09 
                 2.22 
               
               
                 FL_1087 
                 Training 
                 8.19 
                 Alive 
                 9.98 
                 9.27 
                 1.57 
               
               
                 FL_1088 
                 Validation 
                 5.30 
                 Alive 
                 9.22 
                 8.47 
                 1.20 
               
               
                 FL_1089 
                 Training 
                 10.72 
                 Alive 
                 9.42 
                 8.35 
                 0.40 
               
               
                 FL_1090 
                 Validation 
                 10.20 
                 Alive 
                 9.27 
                 8.37 
                 0.82 
               
               
                 FL_1097 
                 Validation 
                 8.79 
                 Dead 
                 9.87 
                 8.92 
                 0.87 
               
               
                 FL_1098 
                 Validation 
                 5.34 
                 Dead 
                 9.33 
                 8.81 
                 1.87 
               
               
                 FL_1099 
                 Training 
                 7.65 
                 Alive 
                 9.73 
                 9.04 
                 1.54 
               
               
                 FL_1102 
                 Validation 
                 13.20 
                 Dead 
                 9.45 
                 8.89 
                 1.79 
               
               
                 FL_1104 
                 Training 
                 8.42 
                 Dead 
                 9.30 
                 8.27 
                 0.48 
               
               
                 FL_1106 
                 Validation 
                 7.94 
                 Alive 
                 9.13 
                 9.19 
                 3.36 
               
               
                 FL_1107 
                 Training 
                 5.01 
                 Dead 
                 9.41 
                 9.32 
                 3.07 
               
               
                 FL_1183 
                 Training 
                 11.56 
                 Dead 
                 9.31 
                 8.53 
                 1.16 
               
               
                 FL_1184 
                 Training 
                 6.93 
                 Dead 
                 9.66 
                 8.83 
                 1.13 
               
               
                 FL_1185 
                 Validation 
                 7.02 
                 Dead 
                 9.23 
                 9.09 
                 2.86 
               
               
                 FL_1186 
                 Training 
                 1.34 
                 Dead 
                 9.01 
                 8.84 
                 2.68 
               
               
                 FL_1416 
                 Validation 
                 6.21 
                 Alive 
                 9.50 
                 8.67 
                 1.08 
               
               
                 FL_1417 
                 Training 
                 2.40 
                 Dead 
                 8.47 
                 8.39 
                 2.73 
               
               
                 FL_1418 
                 Validation 
                 3.59 
                 Alive 
                 8.94 
                 8.42 
                 1.72 
               
               
                 FL_1419 
                 Training 
                 3.85 
                 Alive 
                 9.82 
                 8.56 
                 0.03 
               
               
                 FL_1422 
                 Training 
                 5.72 
                 Alive 
                 9.46 
                 8.49 
                 0.68 
               
               
                 FL_1425 
                 Validation 
                 4.26 
                 Alive 
                 8.93 
                 8.50 
                 1.98 
               
               
                 FL_1426 
                 Training 
                 7.32 
                 Alive 
                 9.08 
                 8.26 
                 0.97 
               
               
                 FL_1427 
                 Training 
                 5.22 
                 Alive 
                 8.57 
                 8.28 
                 2.22 
               
               
                 FL_1428 
                 Validation 
                 5.41 
                 Dead 
                 9.22 
                 8.44 
                 1.10 
               
               
                 FL_1432 
                 Training 
                 3.66 
                 Alive 
                 9.22 
                 8.95 
                 2.51 
               
               
                 FL_1436 
                 Training 
                 9.08 
                 Dead 
                 9.48 
                 8.63 
                 1.02 
               
               
                 FL_1440 
                 Training 
                 7.85 
                 Alive 
                 9.07 
                 8.35 
                 1.22 
               
               
                 FL_1445 
                 Training 
                 9.24 
                 Dead 
                 8.67 
                 8.66 
                 3.01 
               
               
                 FL_1450 
                 Validation 
                 0.65 
                 Dead 
                 9.83 
                 9.99 
                 3.86 
               
               
                 FL_1472 
                 Validation 
                 16.72 
                 Alive 
                 8.85 
                 8.49 
                 2.10 
               
               
                 FL_1473 
                 Training 
                 15.07 
                 Alive 
                 9.75 
                 8.50 
                 0.02 
               
               
                 FL_1474 
                 Validation 
                 2.75 
                 Dead 
                 9.34 
                 9.10 
                 2.62 
               
               
                 FL_1476 
                 Validation 
                 4.08 
                 Dead 
                 9.51 
                 8.87 
                 1.60 
               
               
                 FL_1477 
                 Training 
                 0.59 
                 Dead 
                 9.64 
                 9.06 
                 1.83 
               
               
                 FL_1478 
                 Training 
                 12.47 
                 Dead 
                 9.60 
                 8.87 
                 1.39 
               
               
                 FL_1479 
                 Training 
                 2.29 
                 Dead 
                 8.71 
                 9.07 
                 4.01 
               
               
                 FL_1480 
                 Training 
                 16.29 
                 Alive 
                 9.40 
                 8.67 
                 1.30 
               
               
                 FL_1579 
                 Training 
                 8.22 
                 Dead 
                 8.81 
                 8.44 
                 2.10 
               
               
                 FL_1580 
                 Training 
                 19.30 
                 Alive 
                 9.58 
                 8.52 
                 0.49 
               
               
                 FL_1581 
                 Training 
                 9.52 
                 Dead 
                 9.08 
                 9.02 
                 3.00 
               
               
                 FL_1582 
                 Validation 
                 1.30 
                 Dead 
                 8.40 
                 8.18 
                 2.36 
               
               
                 FL_1583 
                 Training 
                 15.26 
                 Dead 
                 9.47 
                 8.79 
                 1.48 
               
               
                 FL_1584 
                 Training 
                 15.73 
                 Dead 
                 9.44 
                 8.55 
                 0.89 
               
               
                 FL_1585 
                 Validation 
                 0.01 
                 Alive 
                 8.96 
                 8.53 
                 1.96 
               
               
                 FL_1586 
                 Validation 
                 3.11 
                 Alive 
                 9.38 
                 8.55 
                 1.03 
               
               
                 FL_1588 
                 Training 
                 0.49 
                 Dead 
                 9.52 
                 9.06 
                 2.08 
               
               
                 FL_1589 
                 Training 
                 3.15 
                 Alive 
                 9.72 
                 8.74 
                 0.72 
               
               
                 FL_1591 
                 Training 
                 11.22 
                 Alive 
                 9.49 
                 8.62 
                 0.97 
               
               
                 FL_1594 
                 Validation 
                 11.19 
                 Alive 
                 9.25 
                 8.59 
                 1.47 
               
               
                 FL_1595 
                 Training 
                 8.03 
                 Alive 
                 9.75 
                 9.60 
                 3.01 
               
               
                 FL_1598 
                 Validation 
                 2.80 
                 Dead 
                 8.81 
                 8.33 
                 1.79 
               
               
                 FL_1599 
                 Validation 
                 6.17 
                 Alive 
                 9.48 
                 8.65 
                 1.06 
               
               
                 FL_1603 
                 Training 
                 5.17 
                 Dead 
                 9.66 
                 9.75 
                 3.63 
               
               
                 FL_1604 
                 Training 
                 3.98 
                 Dead 
                 9.24 
                 8.86 
                 2.20 
               
               
                 FL_1606 
                 Validation 
                 4.22 
                 Dead 
                 9.45 
                 9.18 
                 2.57 
               
               
                 FL_1607 
                 Validation 
                 8.12 
                 Alive 
                 9.40 
                 8.60 
                 1.13 
               
               
                 FL_1608 
                 Validation 
                 9.70 
                 Alive 
                 8.92 
                 8.41 
                 1.72 
               
               
                 FL_1610 
                 Validation 
                 2.05 
                 Dead 
                 9.33 
                 9.35 
                 3.32 
               
               
                 FL_1611 
                 Validation 
                 10.15 
                 Alive 
                 9.42 
                 8.69 
                 1.31 
               
               
                 FL_1616 
                 Training 
                 2.36 
                 Dead 
                 9.38 
                 8.82 
                 1.78 
               
               
                 FL_1617 
                 Validation 
                 7.85 
                 Alive 
                 8.96 
                 8.49 
                 1.87 
               
               
                 FL_1619 
                 Validation 
                 9.24 
                 Dead 
                 9.43 
                 8.56 
                 0.94 
               
               
                 FL_1620 
                 Validation 
                 9.36 
                 Dead 
                 9.14 
                 8.35 
                 1.04 
               
               
                 FL_1622 
                 Training 
                 14.01 
                 Alive 
                 9.23 
                 8.53 
                 1.33 
               
               
                 FL_1623 
                 Training 
                 9.72 
                 Alive 
                 9.67 
                 8.93 
                 1.38 
               
               
                 FL_1624 
                 Validation 
                 3.98 
                 Dead 
                 9.05 
                 8.50 
                 1.70 
               
               
                 FL_1625 
                 Validation 
                 11.16 
                 Alive 
                 8.98 
                 8.47 
                 1.75 
               
               
                 FL_1626 
                 Validation 
                 6.47 
                 Dead 
                 8.59 
                 8.14 
                 1.76 
               
               
                 FL_1628 
                 Validation 
                 0.82 
                 Dead 
                 9.80 
                 8.72 
                 0.51 
               
               
                 FL_1637 
                 Validation 
                 18.81 
                 Alive 
                 9.95 
                 9.58 
                 2.48 
               
               
                 FL_1638 
                 Validation 
                 4.06 
                 Alive 
                 9.13 
                 8.88 
                 2.51 
               
               
                 FL_1639 
                 Training 
                 4.75 
                 Alive 
                 9.53 
                 8.89 
                 1.62 
               
               
                 FL_1643 
                 Training 
                 0.77 
                 Dead 
                 9.73 
                 9.06 
                 1.58 
               
               
                 FL_1644 
                 Validation 
                 3.84 
                 Alive 
                 9.55 
                 8.68 
                 0.98 
               
               
                 FL_1645 
                 Training 
                 3.56 
                 Alive 
                 9.49 
                 8.70 
                 1.18 
               
               
                 FL_1646 
                 Training 
                 1.97 
                 Dead 
                 9.25 
                 8.61 
                 1.50 
               
               
                 FL_1647 
                 Training 
                 1.22 
                 Dead 
                 9.12 
                 8.89 
                 2.55 
               
               
                 FL_1648 
                 Training 
                 11.01 
                 Alive 
                 9.13 
                 8.12 
                 0.46 
               
               
                 FL_1652 
                 Training 
                 3.72 
                 Dead 
                 9.50 
                 9.14 
                 2.35 
               
               
                 FL_1654 
                 Validation 
                 0.30 
                 Dead 
                 8.74 
                 8.28 
                 1.82 
               
               
                 FL_1655 
                 Training 
                 8.45 
                 Alive 
                 9.51 
                 8.85 
                 1.53 
               
               
                 FL_1656 
                 Validation 
                 9.36 
                 Alive 
                 9.06 
                 8.58 
                 1.87 
               
               
                 FL_1657 
                 Training 
                 10.09 
                 Alive 
                 9.53 
                 8.46 
                 0.44 
               
               
                 FL_1660 
                 Training 
                 2.32 
                 Alive 
                 8.81 
                 8.38 
                 1.91 
               
               
                 FL_1661 
                 Validation 
                 1.48 
                 Alive 
                 9.86 
                 8.90 
                 0.85 
               
               
                 FL_1662 
                 Validation 
                 0.74 
                 Dead 
                 9.57 
                 9.15 
                 2.21 
               
               
                 FL_1664 
                 Validation 
                 4.53 
                 Dead 
                 9.34 
                 8.62 
                 1.31 
               
               
                 FL_1669 
                 Training 
                 4.40 
                 Dead 
                 8.87 
                 8.58 
                 2.30 
               
               
                 FL_1670 
                 Training 
                 1.88 
                 Alive 
                 9.64 
                 9.45 
                 2.86 
               
               
                 FL_1675 
                 Training 
                 4.57 
                 Alive 
                 9.36 
                 8.46 
                 0.84 
               
               
                 FL_1681 
                 Validation 
                 4.23 
                 Alive 
                 9.52 
                 8.63 
                 0.91 
               
               
                 FL_1683 
                 Validation 
                 4.03 
                 Dead 
                 9.95 
                 9.10 
                 1.19 
               
               
                 FL_1684 
                 Training 
                 2.88 
                 Dead 
                 9.53 
                 8.73 
                 1.18 
               
               
                 FL_1716 
                 Validation 
                 9.69 
                 Alive 
                 8.95 
                 8.35 
                 1.50 
               
               
                 FL_1717 
                 Validation 
                 2.01 
                 Dead 
                 9.35 
                 8.88 
                 1.98 
               
               
                 FL_1718 
                 Training 
                 10.35 
                 Alive 
                 9.23 
                 8.13 
                 0.26 
               
               
                 FL_1719 
                 Validation 
                 7.70 
                 Dead 
                 9.13 
                 8.50 
                 1.49 
               
               
                 FL_1720 
                 Training 
                 3.91 
                 Dead 
                 8.78 
                 8.88 
                 3.33 
               
               
                 FL_1729 
                 Training 
                 8.06 
                 Alive 
                 9.35 
                 8.65 
                 1.39 
               
               
                 FL_1732 
                 Validation 
                 0.71 
                 Dead 
                 7.81 
                 8.59 
                 4.86 
               
               
                 FL_1761 
                 Validation 
                 10.83 
                 Alive 
                 9.31 
                 8.55 
                 1.22 
               
               
                 FL_1764 
                 Training 
                 0.42 
                 Dead 
                 9.25 
                 8.87 
                 2.21 
               
               
                 FL_1768 
                 Training 
                 13.04 
                 Alive 
                 9.42 
                 8.47 
                 0.72 
               
               
                 FL_1771 
                 Training 
                 9.26 
                 Dead 
                 9.09 
                 8.67 
                 2.06 
               
               
                 FL_1772 
                 Validation 
                 13.64 
                 Dead 
                 9.49 
                 8.49 
                 0.61 
               
               
                 FL_1788 
                 Training 
                 1.00 
                 Dead 
                 9.09 
                 9.13 
                 3.29 
               
               
                 FL_1790 
                 Training 
                 1.42 
                 Alive 
                 9.85 
                 9.40 
                 2.22 
               
               
                 FL_1792 
                 Validation 
                 2.01 
                 Dead 
                 9.33 
                 8.72 
                 1.61 
               
               
                 FL_1795 
                 Training 
                 0.71 
                 Dead 
                 10.19 
                 9.27 
                 1.08 
               
               
                 FL_1797 
                 Validation 
                 7.17 
                 Alive 
                 9.34 
                 8.92 
                 2.14 
               
               
                 FL_1799 
                 Training 
                 14.18 
                 Alive 
                 9.32 
                 8.63 
                 1.38 
               
               
                 FL_1810 
                 Validation 
                 9.91 
                 Alive 
                 8.66 
                 8.41 
                 2.35 
               
               
                 FL_1811 
                 Validation 
                 3.04 
                 Alive 
                 9.38 
                 8.27 
                 0.29 
               
               
                 FL_1825 
                 Training 
                 2.98 
                 Alive 
                 9.46 
                 9.07 
                 2.25 
               
               
                 FL_1827 
                 Training 
                 3.66 
                 Alive 
                 9.80 
                 8.84 
                 0.83 
               
               
                 FL_1828 
                 Validation 
                 11.51 
                 Alive 
                 8.99 
                 8.09 
                 0.72 
               
               
                 FL_1829 
                 Validation 
                 4.11 
                 Alive 
                 9.57 
                 8.73 
                 1.08 
               
               
                 FL_1830 
                 Validation 
                 5.65 
                 Dead 
                 9.01 
                 8.68 
                 2.25 
               
               
                 FL_1833 
                 Training 
                 11.95 
                 Alive 
                 9.74 
                 8.67 
                 0.51 
               
               
                 FL_1834 
                 Validation 
                 15.92 
                 Alive 
                 9.22 
                 8.72 
                 1.88 
               
               
                 FL_1835 
                 Validation 
                 12.49 
                 Alive 
                 9.26 
                 8.83 
                 2.10 
               
               
                 FL_1836 
                 Validation 
                 12.24 
                 Alive 
                 9.55 
                 8.64 
                 0.85 
               
               
                 FL_1837 
                 Validation 
                 0.55 
                 Dead 
                 9.47 
                 8.84 
                 1.62 
               
               
                 FL_1838 
                 Validation 
                 2.54 
                 Alive 
                 9.90 
                 9.12 
                 1.34 
               
               
                 FL_1839 
                 Training 
                 4.48 
                 Alive 
                 8.56 
                 8.32 
                 2.34 
               
               
                 FL_1841 
                 Training 
                 0.88 
                 Dead 
                 9.32 
                 9.10 
                 2.66 
               
               
                 FL_1842 
                 Validation 
                 4.56 
                 Alive 
                 9.73 
                 8.87 
                 1.07 
               
               
                 FL_1844 
                 Validation 
                 13.39 
                 Alive 
                 9.41 
                 8.55 
                 0.98 
               
               
                 FL_1845 
                 Training 
                 12.92 
                 Dead 
                 9.89 
                 9.04 
                 1.16 
               
               
                 FL_1846 
                 Validation 
                 1.80 
                 Dead 
                 9.79 
                 9.61 
                 2.93 
               
               
                 FL_1848 
                 Training 
                 12.52 
                 Alive 
                 9.76 
                 8.81 
                 0.82 
               
               
                 FL_1851 
                 Training 
                 4.08 
                 Dead 
                 9.43 
                 9.01 
                 2.18 
               
               
                 FL_1853 
                 Validation 
                 12.50 
                 Alive 
                 9.28 
                 8.54 
                 1.25 
               
               
                 FL_1854 
                 Validation 
                 13.81 
                 Alive 
                 9.32 
                 8.84 
                 1.98 
               
               
                 FL_1855 
                 Validation 
                 9.96 
                 Dead 
                 9.31 
                 8.39 
                 0.75 
               
               
                 FL_1857 
                 Validation 
                 8.39 
                 Dead 
                 9.80 
                 9.14 
                 1.65 
               
               
                 FL_1861 
                 Validation 
                 3.19 
                 Dead 
                 9.47 
                 8.57 
                 0.88 
               
               
                 FL_1862 
                 Validation 
                 7.22 
                 Dead 
                 8.96 
                 8.33 
                 1.44 
               
               
                 FL_1863 
                 Validation 
                 10.77 
                 Dead 
                 9.31 
                 8.85 
                 2.00 
               
               
                 FL_1864 
                 Training 
                 14.25 
                 Alive 
                 9.98 
                 9.12 
                 1.17 
               
               
                 FL_1866 
                 Training 
                 10.72 
                 Dead 
                 9.93 
                 8.94 
                 0.79 
               
               
                 FL_1870 
                 Validation 
                 6.41 
                 Dead 
                 10.01 
                 9.22 
                 1.36 
               
               
                 FL_1873 
                 Training 
                 7.78 
                 Dead 
                 9.39 
                 8.66 
                 1.30 
               
               
                 FL_1874 
                 Validation 
                 3.15 
                 Dead 
                 9.38 
                 8.74 
                 1.53 
               
               
                 FL_1876 
                 Validation 
                 15.07 
                 Alive 
                 9.59 
                 8.72 
                 0.98 
               
               
                 FL_1879 
                 Training 
                 7.13 
                 Dead 
                 9.25 
                 8.62 
                 1.53 
               
               
                 FL_1880 
                 Validation 
                 12.84 
                 Dead 
                 8.82 
                 8.35 
                 1.82 
               
               
                 FL_1882 
                 Training 
                 8.84 
                 Dead 
                 9.43 
                 8.76 
                 1.49 
               
               
                 FL_1884 
                 Validation 
                 11.92 
                 Dead 
                 9.48 
                 9.14 
                 2.41 
               
               
                 FL_1885 
                 Validation 
                 15.49 
                 Alive 
                 9.70 
                 8.85 
                 1.11 
               
               
                 FL_1887 
                 Training 
                 5.14 
                 Dead 
                 9.47 
                 8.57 
                 0.87 
               
               
                 FL_1888 
                 Training 
                 15.08 
                 Alive 
                 9.83 
                 8.97 
                 1.11 
               
               
                 FL_1890 
                 Training 
                 3.03 
                 Dead 
                 9.29 
                 9.05 
                 2.60 
               
               
                 FL_1894 
                 Training 
                 11.37 
                 Dead 
                 9.01 
                 8.64 
                 2.13 
               
               
                 FL_1896 
                 Training 
                 12.03 
                 Alive 
                 9.80 
                 8.56 
                 0.08 
               
               
                 FL_1897 
                 Training 
                 9.63 
                 Alive 
                 9.02 
                 8.33 
                 1.29 
               
               
                 FL_1898 
                 Training 
                 5.20 
                 Alive 
                 8.82 
                 8.25 
                 1.54 
               
               
                 FL_1900 
                 Validation 
                 7.38 
                 Alive 
                 9.13 
                 8.26 
                 0.85 
               
               
                 FL_1903 
                 Validation 
                 28.25 
                 Alive 
                 9.07 
                 8.46 
                 1.54 
               
               
                 FL_1904 
                 Validation 
                 7.36 
                 Alive 
                 9.16 
                 8.53 
                 1.50 
               
               
                 FL_1905 
                 Validation 
                 3.68 
                 Dead 
                 9.25 
                 8.38 
                 0.87 
               
               
                 FL_1906 
                 Training 
                 2.35 
                 Dead 
                 8.04 
                 8.69 
                 4.56 
               
               
                 FL_1907 
                 Validation 
                 2.35 
                 Dead 
                 8.11 
                 8.21 
                 3.11 
               
               
                 FL_1910 
                 Training 
                 13.84 
                 Alive 
                 9.36 
                 8.72 
                 1.56 
               
               
                 FL_1912 
                 Validation 
                 0.73 
                 Dead 
                 9.30 
                 9.21 
                 3.02 
               
               
                 FL_1913 
                 Training 
                 2.57 
                 Alive 
                 9.77 
                 8.51 
                 0.01 
               
               
                 FL_1916 
                 Validation 
                 11.61 
                 Alive 
                 9.22 
                 8.49 
                 1.24 
               
               
                 FL_1918 
                 Validation 
                 9.95 
                 Dead 
                 9.54 
                 8.77 
                 1.26 
               
               
                 FL_1919 
                 Training 
                 10.84 
                 Dead 
                 9.51 
                 8.81 
                 1.44 
               
               
                 FL_735 
                 Validation 
                 11.05 
                 Dead 
                 8.81 
                 8.23 
                 1.53 
               
               
                 FL_738 
                 Validation 
                 10.15 
                 Dead 
                 9.19 
                 8.79 
                 2.13 
               
               
                 FL_739 
                 Training 
                 10.80 
                 Dead 
                 9.29 
                 8.77 
                 1.85 
               
               
                 FL_878 
                 Validation 
                 3.87 
                 Dead 
                 8.85 
                 8.54 
                 2.26 
               
               
                 FL_879 
                 Training 
                 4.34 
                 Dead 
                 8.95 
                 8.74 
                 2.56 
               
               
                 FL_886 
                 Validation 
                 3.29 
                 Alive 
                 9.43 
                 8.72 
                 1.40 
               
               
                 FL_888 
                 Validation 
                 1.32 
                 Dead 
                 8.76 
                 8.49 
                 2.34 
               
               
                 FL_1627 
                 Training 
                 NA 
                 NA 
                 9.60 
                 8.51 
                 0.40 
               
               
                 FL_1429 
                 Training 
                 NA 
                 NA 
                 8.69 
                 8.28 
                 1.93 
               
               
                 FL_1850 
                 Validation 
                 NA 
                 NA 
                 9.75 
                 8.83 
                 0.92 
               
               
                 FL_1735 
                 Validation 
                 NA 
                 NA 
                 7.32 
                 8.30 
                 5.24 
               
               
                   
               
            
           
         
       
     
     In order to visualize the predictive power of the model, the FL samples were ranked according to their survival predictor scores and divided into four quartiles. Kaplan-Meier plots of overall survival showed clear differences in survival rate in the validation set ( FIG. 5 ). The median survival for each of the four quartiles is set forth in Table 2362. 
     
       
         
           
               
               
               
             
               
                   
                 TABLE 2362 
               
               
                   
                   
               
               
                   
                 Quartile 
                 Median survival (years) 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
            
               
                   
                 1 
                 13.6 
               
               
                   
                 2 
                 11.1 
               
               
                   
                 3 
                 10.8 
               
               
                   
                 4 
                 3.9 
               
               
                   
                   
               
            
           
         
       
     
     Various clinical variables were found to be significantly associated with survival, including the IPI and some of its components and the presence of B-symptoms. The gene expression-based model was independent of each of these variables at predicting survival. These clinical variables and the relative risk of death associated with each are summarized in Table 2363. 
     
       
         
           
               
               
               
               
               
             
               
                   
                 TABLE 2363 
               
             
            
               
                   
                   
               
               
                   
                   
                   
                   
                 Multivariate (clinical 
               
               
                   
                   
                   
                 Univariate (clinical 
                 variable + survival 
               
               
                   
                   
                   
                 variable only) 
                 predictor score) 
               
               
                   
                   
                   
                 relative risk of death 
                 relative risk of death 
               
               
                   
                 % of 
                 % of 
                 among patients in 
                 among patients in 
               
               
                   
                 patients 1   
                 patients 1   
                 validation set 
                 validation set 
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 Clinical 
                   
                 Training 
                 Validation 
                 RR 2  (95% 
                   
                 RR 2  (95% 
                   
               
               
                 variable 
                 Criteria 
                 set 
                 set 
                 C.I.) 
                 p-value 
                 C.I.) 
                 p-value 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
            
               
                 Age 
                   60 
                 64.5 
                 70.2 
                 1.90 
                 0.044 
                 2.21 (1.48-3.29) 
                 &lt;0.001 
               
               
                   
                 &gt;60 
                 35.5 
                 29.8 
                 (1.02-3.56) 
               
               
                 Stage 
                 I-II 
                 33.3 
                 25 
                 1.31 
                 0.447 
                 2.31 (1.51-3.52) 
                 &lt;0.001 
               
               
                   
                 III-IV 
                 66.7 
                 75 
                 (0.65-2.64) 
               
               
                 Extranodal 
                    2 
                 5.4 
                 20.2 
                 1.58 
                 0.163 
                 2.21 (1.48-3.30) 
                 &lt;0.001 
               
               
                 sites (#) 
                  &lt;2 
                 94.6 
                 79.8 
                 (0.83-2.99) 
               
               
                 LDH 
                 Normal 
                 77.1 
                 66.2 
                 1.77 
                 0.065 
                 2.40 (1.57-3.67) 
                 &lt;0.001 
               
               
                   
                 Greater 
                 22.9 
                 33.8 
                 (0.97-3.24) 
               
               
                   
                 than 
               
               
                   
                 normal 
               
               
                 ECOG 
                    2 
                 9.4 
                 12.5 
                 2.05 
                 0.090 
                 2.17 (1.40-3.35) 
                 &lt;0.001 
               
               
                 performance 
                  &lt;2 
                 90.6 
                 87.5 
                 (0.89-4.71) 
               
               
                 status 
               
               
                 Gender 
                 Male 
                 42 
                 65 
                 1.62 
                 0.105 
                 2.17 (1.45-3.25) 
                 &lt;0.001 
               
               
                   
                 Female 
                 58 
                 35 
                 (0.90-2.90) 
               
               
                 B-symptoms 
                 Present 
                 17.2 
                 21.3 
                 2.05 
                 0.029 
                 2.10 (1.37-3.23) 
                 &lt;0.001 
               
               
                   
                 Absent 
                 82.8 
                 78.7 
                 (1.08-3.89) 
               
               
                 Grade 3   
                    1 
                 45 
                 43.4 
                 N/A 
                 0.118 
                 2.55 (1.63-3.99) 
                 &lt;0.001 
               
               
                   
                    2 
                 34.8 
                 33.3 
                 2.03 
               
               
                   
                   
                   
                   
                 (1.04-3.96) 
               
               
                   
                    3 
                 20.2 
                 23.3 
                 1.39 
               
               
                   
                   
                   
                   
                 (0.65-2.98) 
               
               
                 Int&#39;l. 
                 Scores 
                 63.1 
                 47.5 
                 N/A 
                 0.029 
                 2.28 (1.46-3.57) 
                 &lt;0.001 
               
               
                 Prognostic 
                 0-1 
               
               
                 Index 4   
                 Scores 
                 33.3 
                 45 
                 2.07 
               
               
                   
                 2-3 
                   
                   
                 (1.07-4.00) 
               
               
                   
                 Scores 
                 3.6 
                 7.5 
                 3.73 
               
               
                   
                 4-5 
                   
                   
                  (1.18-11.18) 
               
               
                   
               
               
                   1 Due to rounding, percentages may not total 100 
               
               
                   2 Relative risk of death (RR) based on 2-fold increase in expression 
               
               
                   3 RR for grades 2 and 3 calculated with respect to risk of death for grade 1. The p-value is calculated for all grades. 
               
               
                   4 RR for scores 2-3 and 4-5 calculated with respect to risk of death for scores 0-1. 
               
               
                 The p-value is calculated for all grades. 
               
            
           
         
       
     
     The samples in the validation set were divided into three groups based on their IPI score, and the relationship between survival and IPI score was visualized by Kaplan-Meier plot ( FIG. 6 ). Among validation set samples from the low-risk (IPI 0-1) and intermediate risk (IPI 2-3) IPI groups, the gene-expression-based survival predictor could stratify patients into groups differing by more than 5 years with regards to median survival ( FIG. 7 ). The high-risk IPI group (IPI 4-5) comprised less than 5% of the samples, and was omitted from this analysis. These results demonstrate that the gene expression-based model is not merely acting as a surrogate for clinical variables that are known to predict survival in FL, but rather it identifies distinct biological attributes of the tumors that are associated with survival. 
     Example 4 
     Development of a Second FL Survival Predictor Using Gene Expression Data from Affymetrix U133A and U133B Microarrays 
     191 FL were divided into two equivalent groups: a training set (95 samples) for developing the survival prediction model, and a validation set (96 samples) for evaluating the reproducibility of the model. Gene expression data from Affymetrix U133A and U133B microarrays was obtained for each of the samples. A Cox proportional hazards model was used to identify survival predictor genes whose expression levels were associated with long survival (good prognosis genes) or short survival (poor prognosis genes) in the training set. The correlation between expression and survival for each gene on the microarrays is provided in the final two columns of Table 1710. The first of these two columns (“FL_Cox_coefficient”) provides a Cox coefficient indicating the extent to which a 2-fold increase in expression of a particular gene affects mortality. A positive Cox coefficient indicates increasing mortality with increasing expression of the gene, while a negative Cox coefficient indicates decreasing mortality with increasing expression of the gene. The second of these two columns provides a Cox p-value indicating the estimated probability that the increase or decrease in survival associated with the gene would occur by chance if there was no connection between the expression of the gene and survival. 
     A hierarchical clustering algorithm (Eisen 1998) was used to identify gene expression signatures within the good and poor prognosis genes according to their expression pattern across all samples. Eight clusters of coordinately regulated genes were observed within the good prognosis gene set and six clusters were observed in the poor prognosis gene sets. The expression level of every component gene in each of these gene expression signatures was averaged to create a gene expression signature value. After averaging, only ten of the gene expression signatures were found to be significantly associated with survival in the training set (p&lt;0.01). To create a multivariate model of survival, different combinations of these ten gene expression signature averages were generated and evaluated for their ability to predict survival within the training set. Among models consisting of two signatures, an exceptionally strong statistical synergy was noted between one signature from the good prognosis group and one from the poor prognosis group. These gene expression signatures were termed “T-cell” and “macrophage” based on the biological function of certain genes within each signature. The T-cell gene expression signature included genes that were typically expressed in T-cells, while the macrophage gene expression signature included a number of genes typically expressed in macrophages. Although these two signatures taken individually were not the best predictors of survival, the binary model formed by combining the two was more predictive than any combination of three signatures that did not contain these two signatures. Using these two signatures as an anchor, other signatures were added to the model using a step up procedure (Drapner 1966). Only one of the remaining eight signatures, termed the B-cell differentiation signature, contributed significantly to the model in the training set (p=0.054). The B-cell differentiation signature included a number of genes that appear to be involved in B-cell signal transduction. Table 2364 lists the genes that were used to generate the gene expression signature values for the T-cell, macrophage, and B-cell differentiation gene expression signatures. 
                                 TABLE 2364               Signature   UNIQID   Unigene ID Build 167   Gene symbol                                                B-cell differentiation   1119350   331141   ALDH2       B-cell differentiation   1130922   459987   ANP32B       B-cell differentiation   1130923   459987   ANP32B       B-cell differentiation   1099291   130774   C9orf105       B-cell differentiation   1102859   446195   FLJ42418       B-cell differentiation   1120976   245644   GCHFR       B-cell differentiation   1098862   303669   MGC26694       B-cell differentiation   1111070   202201       B-cell differentiation   1105935       B-cell differentiation   1139017   274424   NANS       B-cell differentiation   1108988   3532   NLK       B-cell differentiation   1114726   3532   NLK       B-cell differentiation   1097897   266175   PAG       B-cell differentiation   1097901   266175   PAG       B-cell differentiation   1119813   155342   PRKCD       B-cell differentiation   1123298   20191   SIAH2       B-cell differentiation   1101439   63335   TERF2       B-cell differentiation   1120316   63335   TERF2       B-cell differentiation   1096035   105794   UGCGL1       T-cell   1134945   81897   KIAA1128       T-cell   1134069   405667   CD8B1       T-cell   1137809   405667   CD8B1       T-cell   1119251   433941   SEPW1       T-cell   1096579   117339   HCST       T-cell   1101004   2969   SKI       T-cell   1137137   195464   FLNA       T-cell   1100871   48353       T-cell   1139461   14770   BIN2       T-cell   1128395   7188   SEMA4C       T-cell   1119880   442844   FMOD       T-cell   1130676   194431   KIAA0992       T-cell   1130668   194431   KIAA0992       T-cell   1135968   119000   ACTN1       T-cell   1097329   528675   TEAD1       T-cell   1098548   436639   NFIC       T-cell   1123038   119000   ACTN1       T-cell   1128356   415792   C1RL       T-cell   1133408   12802   DDEF2       T-cell   1140524   10784   C6orf37       T-cell   1119838   469951   GNAQ       T-cell   1097255   380144       T-cell   1098152   377588   KIAA1450       T-cell   1115194   270737   TNFSF13B       T-cell   1124760   419149   JAM3       T-cell   1120267   256278   TNFRSF1B       T-cell   1137289   36972   CD7       T-cell   1137534   36972   CD7       T-cell   1097307   379754   LOC340061       T-cell   1123613   97087   CD3Z       T-cell   1121720   80642   STAT4       T-cell   1120196   173802   TBC1D4       T-cell   1136087   211576   ITK       T-cell   1132104   173802   TBC1D4       T-cell   1140391   44865   LEF1       T-cell   1098405   362807   IL7R       T-cell   1135743   299558   TNFRSF25       T-cell   1136048   299558   TNFRSF25       T-cell   1123875   428   FLT3LG       T-cell   1098893   43577   ATP8B2       T-cell   1097561   19221   C20orf112       T-cell   1122956   113987   LGALS2       T-cell   1121406       TNFSF12       T-cell   1125532       T-cell   1138538   2014   TRD       T-cell   1103303   49605   C9orf52       T-cell   1119924   32309   INPP1       Macrophage   1123682   114408   TLR5       Macrophage   1099124   355455   SEPT10       Macrophage   1123401   50130   NDN       Macrophage   1134379   150833   C4A       Macrophage   1137481   150833   C4A       Macrophage   1132220   448805   GPRC5B       Macrophage   1119400   181046   DUSP3       Macrophage   1131119   349656   SCARB2       Macrophage   1123566   155935   C3AR1       Macrophage   1138443   77424   FCGR1A       Macrophage   1127943   9641   C1QA       Macrophage   1119998   8986   C1QB       Macrophage   1132433   14732   ME1       Macrophage   1119260   18069   LGMN       Macrophage   1098278   166017   MITF                    
The three signatures were used to generate a survival predictor score using the following equation:
 Survival predictor score=[2.053*(macrophage gene expression signature value)]−[2.344*(T-cell gene expression signature value)]−[0.729*(B-cell differentiation gene expression signature value)]. 
A higher survival predictor score was associated with worse outcome. According to a likelihood ratio test adjusted for the number of variables included, this model was significant in predicting survival in both the training set (p=1.8×10 −8 ) and the validation set (p=2.0×10 −5 ). For the 187 FL samples with available clinical data, the survival predictor score had a mean of −11.9 and a standard deviation of 0.9418, with each unit increase in the predictor score corresponding to a 2.5 fold increase in the relative risk of death. Data for all 191 samples is shown in Table 2365.
 
     
       
         
           
               
               
               
               
               
               
             
               
                 TABLE 2365 
               
               
                   
               
               
                   
                   
                 B cell 
                 T-cell 
                 Macro- 
                   
               
               
                   
                   
                 differentiation 
                 sig- 
                 phage 
                 Survival 
               
               
                 Sample 
                   
                 signature 
                 nature 
                 signature 
                 predictor 
               
               
                 ID # 
                 Set 
                 value 
                 value 
                 value 
                 score 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 FL_1073 
                 Training 
                 9.70 
                 9.14 
                 8.58 
                 −10.89 
               
               
                 FL_1074 
                 Training 
                 11.11 
                 9.06 
                 8.52 
                 −11.84 
               
               
                 FL_1075 
                 Validation 
                 11.23 
                 8.92 
                 8.75 
                 −11.15 
               
               
                 FL_1076 
                 Training 
                 10.02 
                 9.21 
                 8.59 
                 −11.25 
               
               
                 FL_1077 
                 Training 
                 9.94 
                 9.77 
                 8.44 
                 −12.82 
               
               
                 FL_1078 
                 Training 
                 10.67 
                 9.32 
                 8.21 
                 −12.76 
               
               
                 FL_1080 
                 Training 
                 10.62 
                 9.44 
                 8.88 
                 −11.64 
               
               
                 FL_1081 
                 Validation 
                 10.38 
                 9.00 
                 8.09 
                 −12.04 
               
               
                 FL_1083 
                 Training 
                 10.29 
                 9.77 
                 8.74 
                 −12.47 
               
               
                 FL_1085 
                 Validation 
                 9.87 
                 9.24 
                 8.43 
                 −11.55 
               
               
                 FL_1086 
                 Validation 
                 10.03 
                 9.50 
                 9.02 
                 −11.06 
               
               
                 FL_1087 
                 Training 
                 9.83 
                 9.98 
                 9.37 
                 −11.31 
               
               
                 FL_1088 
                 Validation 
                 10.57 
                 9.21 
                 8.29 
                 −12.27 
               
               
                 FL_1089 
                 Training 
                 10.30 
                 9.38 
                 8.27 
                 −12.53 
               
               
                 FL_1090 
                 Validation 
                 9.74 
                 9.24 
                 8.20 
                 −11.93 
               
               
                 FL_1097 
                 Validation 
                 9.57 
                 9.82 
                 8.80 
                 −11.93 
               
               
                 FL_1098 
                 Validation 
                 11.08 
                 9.40 
                 8.97 
                 −11.69 
               
               
                 FL_1099 
                 Training 
                 10.23 
                 9.70 
                 9.12 
                 −11.46 
               
               
                 FL_1102 
                 Validation 
                 9.66 
                 9.46 
                 8.90 
                 −10.93 
               
               
                 FL_1104 
                 Training 
                 10.72 
                 9.19 
                 8.20 
                 −12.53 
               
               
                 FL_1106 
                 Validation 
                 11.11 
                 9.17 
                 9.57 
                 −9.96 
               
               
                 FL_1107 
                 Training 
                 9.70 
                 9.42 
                 9.55 
                 −9.54 
               
               
                 FL_1183 
                 Training 
                 9.85 
                 9.25 
                 8.44 
                 −11.54 
               
               
                 FL_1184 
                 Training 
                 10.12 
                 9.57 
                 8.86 
                 −11.63 
               
               
                 FL_1185 
                 Validation 
                 10.75 
                 9.21 
                 9.13 
                 −10.68 
               
               
                 FL_1186 
                 Training 
                 9.76 
                 8.88 
                 8.83 
                 −9.80 
               
               
                 FL_1416 
                 Validation 
                 9.94 
                 9.45 
                 8.59 
                 −11.77 
               
               
                 FL_1417 
                 Training 
                 10.12 
                 8.53 
                 8.43 
                 −10.08 
               
               
                 FL_1418 
                 Validation 
                 9.35 
                 8.86 
                 8.27 
                 −10.59 
               
               
                 FL_1419 
                 Training 
                 10.20 
                 9.76 
                 8.53 
                 −12.81 
               
               
                 FL_1422 
                 Training 
                 10.22 
                 9.48 
                 8.40 
                 −12.43 
               
               
                 FL_1425 
                 Validation 
                 9.61 
                 8.89 
                 8.58 
                 −10.23 
               
               
                 FL_1426 
                 Training 
                 10.80 
                 9.06 
                 8.13 
                 −12.41 
               
               
                 FL_1427 
                 Training 
                 10.27 
                 8.56 
                 8.13 
                 −10.87 
               
               
                 FL_1428 
                 Validation 
                 10.76 
                 9.25 
                 8.38 
                 −12.32 
               
               
                 FL_1432 
                 Training 
                 10.51 
                 9.17 
                 9.04 
                 −10.59 
               
               
                 FL_1436 
                 Training 
                 9.69 
                 9.40 
                 8.61 
                 −11.42 
               
               
                 FL_1440 
                 Training 
                 9.82 
                 9.04 
                 8.21 
                 −11.50 
               
               
                 FL_1445 
                 Training 
                 9.24 
                 8.69 
                 8.62 
                 −9.41 
               
               
                 FL_1450 
                 Validation 
                 9.70 
                 9.88 
                 10.37 
                 −8.93 
               
               
                 FL_1472 
                 Validation 
                 10.78 
                 8.96 
                 8.51 
                 −11.40 
               
               
                 FL_1473 
                 Training 
                 9.99 
                 9.70 
                 8.41 
                 −12.75 
               
               
                 FL_1474 
                 Validation 
                 10.21 
                 9.27 
                 9.05 
                 −10.59 
               
               
                 FL_1476 
                 Validation 
                 9.82 
                 9.44 
                 8.78 
                 −11.27 
               
               
                 FL_1477 
                 Training 
                 9.32 
                 9.61 
                 9.03 
                 −10.78 
               
               
                 FL_1478 
                 Training 
                 10.19 
                 9.60 
                 8.81 
                 −11.83 
               
               
                 FL_1479 
                 Training 
                 10.69 
                 8.78 
                 9.09 
                 −9.71 
               
               
                 FL_1480 
                 Training 
                 10.10 
                 9.42 
                 8.70 
                 −11.57 
               
               
                 FL_1579 
                 Training 
                 10.15 
                 8.82 
                 8.24 
                 −11.15 
               
               
                 FL_1580 
                 Training 
                 10.31 
                 9.59 
                 8.50 
                 −12.54 
               
               
                 FL_1581 
                 Training 
                 9.91 
                 8.96 
                 9.05 
                 −9.66 
               
               
                 FL_1582 
                 Validation 
                 9.73 
                 8.31 
                 8.06 
                 −10.03 
               
               
                 FL_1583 
                 Training 
                 10.95 
                 9.45 
                 8.86 
                 −11.95 
               
               
                 FL_1584 
                 Training 
                 9.98 
                 9.38 
                 8.46 
                 −11.89 
               
               
                 FL_1585 
                 Validation 
                 10.53 
                 8.88 
                 8.46 
                 −11.11 
               
               
                 FL_1586 
                 Validation 
                 10.00 
                 9.30 
                 8.42 
                 −11.81 
               
               
                 FL_1588 
                 Training 
                 9.59 
                 9.41 
                 8.94 
                 −10.68 
               
               
                 FL_1589 
                 Training 
                 10.29 
                 9.68 
                 8.73 
                 −12.27 
               
               
                 FL_1591 
                 Training 
                 10.44 
                 9.45 
                 8.56 
                 −12.18 
               
               
                 FL_1594 
                 Validation 
                 10.01 
                 9.25 
                 8.56 
                 −11.41 
               
               
                 FL_1595 
                 Training 
                 9.61 
                 9.75 
                 9.65 
                 −10.07 
               
               
                 FL_1598 
                 Validation 
                 11.18 
                 8.80 
                 8.31 
                 −11.71 
               
               
                 FL_1599 
                 Validation 
                 10.55 
                 9.48 
                 8.60 
                 −12.24 
               
               
                 FL_1603 
                 Training 
                 9.40 
                 9.60 
                 9.77 
                 −9.31 
               
               
                 FL_1604 
                 Training 
                 9.92 
                 9.21 
                 8.90 
                 −10.54 
               
               
                 FL_1606 
                 Validation 
                 9.87 
                 9.45 
                 9.17 
                 −10.52 
               
               
                 FL_1607 
                 Validation 
                 9.76 
                 9.37 
                 8.50 
                 −11.63 
               
               
                 FL_1608 
                 Validation 
                 9.92 
                 8.90 
                 8.39 
                 −10.85 
               
               
                 FL_1610 
                 Validation 
                 10.02 
                 9.38 
                 9.74 
                 −9.30 
               
               
                 FL_1611 
                 Validation 
                 10.18 
                 9.41 
                 8.69 
                 −11.64 
               
               
                 FL_1616 
                 Training 
                 9.62 
                 9.33 
                 8.85 
                 −10.71 
               
               
                 FL_1617 
                 Validation 
                 9.90 
                 8.95 
                 8.39 
                 −10.98 
               
               
                 FL_1619 
                 Validation 
                 9.98 
                 9.37 
                 8.47 
                 −11.85 
               
               
                 FL_1620 
                 Validation 
                 9.43 
                 8.95 
                 8.12 
                 −11.19 
               
               
                 FL_1622 
                 Training 
                 9.84 
                 9.15 
                 8.31 
                 −11.56 
               
               
                 FL_1623 
                 Training 
                 9.95 
                 9.61 
                 8.97 
                 −11.37 
               
               
                 FL_1624 
                 Validation 
                 10.55 
                 9.06 
                 8.43 
                 −11.61 
               
               
                 FL_1625 
                 Validation 
                 10.00 
                 8.89 
                 8.23 
                 −11.22 
               
               
                 FL_1626 
                 Validation 
                 11.05 
                 8.62 
                 8.10 
                 −11.62 
               
               
                 FL_1628 
                 Validation 
                 10.08 
                 9.81 
                 8.66 
                 −12.57 
               
               
                 FL_1637 
                 Validation 
                 9.77 
                 9.95 
                 9.59 
                 −10.76 
               
               
                 FL_1638 
                 Validation 
                 10.25 
                 9.20 
                 9.07 
                 −10.41 
               
               
                 FL_1639 
                 Training 
                 10.29 
                 9.52 
                 8.99 
                 −11.35 
               
               
                 FL_1643 
                 Training 
                 9.80 
                 9.72 
                 9.00 
                 −11.46 
               
               
                 FL_1644 
                 Validation 
                 9.51 
                 9.46 
                 8.61 
                 −11.43 
               
               
                 FL_1645 
                 Training 
                 9.39 
                 9.46 
                 8.70 
                 −11.15 
               
               
                 FL_1646 
                 Training 
                 9.90 
                 9.25 
                 8.52 
                 −11.42 
               
               
                 FL_1647 
                 Training 
                 9.51 
                 9.12 
                 8.95 
                 −9.92 
               
               
                 FL_1648 
                 Training 
                 10.02 
                 9.18 
                 7.86 
                 −12.67 
               
               
                 FL_1652 
                 Training 
                 9.62 
                 9.39 
                 9.19 
                 −10.16 
               
               
                 FL_1654 
                 Validation 
                 10.32 
                 8.59 
                 8.10 
                 −11.02 
               
               
                 FL_1655 
                 Training 
                 10.12 
                 9.53 
                 8.75 
                 −11.74 
               
               
                 FL_1656 
                 Validation 
                 10.54 
                 9.08 
                 8.55 
                 −11.42 
               
               
                 FL_1657 
                 Training 
                 10.53 
                 9.53 
                 8.55 
                 −12.46 
               
               
                 FL_1660 
                 Training 
                 10.24 
                 8.75 
                 8.27 
                 −10.99 
               
               
                 FL_1661 
                 Validation 
                 10.08 
                 9.85 
                 9.00 
                 −11.97 
               
               
                 FL_1662 
                 Validation 
                 9.85 
                 9.56 
                 9.49 
                 −10.11 
               
               
                 FL_1664 
                 Validation 
                 10.16 
                 9.35 
                 8.48 
                 −11.92 
               
               
                 FL_1669 
                 Training 
                 9.48 
                 8.76 
                 8.28 
                 −10.45 
               
               
                 FL_1670 
                 Training 
                 9.76 
                 9.66 
                 9.66 
                 −9.92 
               
               
                 FL_1675 
                 Training 
                 10.57 
                 9.28 
                 8.41 
                 −12.18 
               
               
                 FL_1681 
                 Validation 
                 10.48 
                 9.52 
                 8.66 
                 −12.19 
               
               
                 FL_1683 
                 Validation 
                 9.88 
                 9.92 
                 9.07 
                 −11.83 
               
               
                 FL_1684 
                 Training 
                 9.64 
                 9.53 
                 8.85 
                 −11.20 
               
               
                 FL_1716 
                 Validation 
                 9.90 
                 8.91 
                 8.22 
                 −11.23 
               
               
                 FL_1717 
                 Validation 
                 9.87 
                 9.34 
                 8.95 
                 −10.71 
               
               
                 FL_1718 
                 Training 
                 10.00 
                 9.21 
                 7.98 
                 −12.49 
               
               
                 FL_1719 
                 Validation 
                 9.87 
                 9.06 
                 8.42 
                 −11.14 
               
               
                 FL_1720 
                 Training 
                 10.70 
                 8.77 
                 8.92 
                 −10.05 
               
               
                 FL_1729 
                 Training 
                 10.50 
                 9.23 
                 8.65 
                 −11.53 
               
               
                 FL_1732 
                 Validation 
                 9.91 
                 7.68 
                 8.54 
                 −7.69 
               
               
                 FL_1761 
                 Validation 
                 9.81 
                 9.22 
                 8.39 
                 −11.54 
               
               
                 FL_1764 
                 Training 
                 9.81 
                 9.24 
                 8.77 
                 −10.80 
               
               
                 FL_1768 
                 Training 
                 10.12 
                 9.36 
                 8.50 
                 −11.86 
               
               
                 FL_1771 
                 Training 
                 9.92 
                 9.12 
                 8.68 
                 −10.79 
               
               
                 FL_1772 
                 Validation 
                 9.72 
                 9.42 
                 8.43 
                 −11.87 
               
               
                 FL_1788 
                 Training 
                 9.65 
                 9.05 
                 9.12 
                 −9.51 
               
               
                 FL_1790 
                 Training 
                 9.58 
                 9.83 
                 9.48 
                 −10.56 
               
               
                 FL_1792 
                 Validation 
                 9.79 
                 9.29 
                 8.67 
                 −11.11 
               
               
                 FL_1795 
                 Training 
                 9.58 
                 10.18 
                 9.33 
                 −11.69 
               
               
                 FL_1797 
                 Validation 
                 9.93 
                 9.26 
                 8.79 
                 −10.90 
               
               
                 FL_1799 
                 Training 
                 10.49 
                 9.28 
                 8.64 
                 −11.65 
               
               
                 FL_1810 
                 Validation 
                 10.06 
                 8.55 
                 8.21 
                 −10.52 
               
               
                 FL_1811 
                 Validation 
                 9.84 
                 9.37 
                 8.08 
                 −12.56 
               
               
                 FL_1825 
                 Training 
                 10.49 
                 9.44 
                 9.03 
                 −11.24 
               
               
                 FL_1827 
                 Training 
                 10.06 
                 9.76 
                 8.84 
                 −12.08 
               
               
                 FL_1828 
                 Validation 
                 10.55 
                 8.93 
                 7.67 
                 −12.87 
               
               
                 FL_1829 
                 Validation 
                 9.85 
                 9.58 
                 8.65 
                 −11.87 
               
               
                 FL_1830 
                 Validation 
                 10.80 
                 8.99 
                 8.67 
                 −11.15 
               
               
                 FL_1833 
                 Training 
                 10.41 
                 9.83 
                 8.82 
                 −12.52 
               
               
                 FL_1834 
                 Validation 
                 10.81 
                 9.25 
                 8.63 
                 −11.85 
               
               
                 FL_1835 
                 Validation 
                 9.36 
                 9.25 
                 8.91 
                 −10.21 
               
               
                 FL_1836 
                 Validation 
                 10.58 
                 9.58 
                 8.61 
                 −12.50 
               
               
                 FL_1837 
                 Validation 
                 10.22 
                 9.47 
                 8.76 
                 −11.68 
               
               
                 FL_1838 
                 Validation 
                 10.51 
                 9.89 
                 9.19 
                 −11.98 
               
               
                 FL_1839 
                 Training 
                 10.79 
                 8.54 
                 8.19 
                 −11.09 
               
               
                 FL_1841 
                 Training 
                 10.32 
                 9.31 
                 9.18 
                 −10.48 
               
               
                 FL_1842 
                 Validation 
                 10.36 
                 9.69 
                 8.92 
                 −11.95 
               
               
                 FL_1844 
                 Validation 
                 10.92 
                 9.43 
                 8.49 
                 −12.65 
               
               
                 FL_1845 
                 Training 
                 9.87 
                 9.87 
                 9.06 
                 −11.73 
               
               
                 FL_1846 
                 Validation 
                 9.66 
                 9.81 
                 9.93 
                 −9.63 
               
               
                 FL_1848 
                 Training 
                 9.82 
                 9.74 
                 8.70 
                 −12.14 
               
               
                 FL_1851 
                 Training 
                 9.89 
                 9.47 
                 9.03 
                 −10.87 
               
               
                 FL_1853 
                 Validation 
                 9.96 
                 9.28 
                 8.54 
                 −11.49 
               
               
                 FL_1854 
                 Validation 
                 9.97 
                 9.29 
                 8.73 
                 −11.12 
               
               
                 FL_1855 
                 Validation 
                 9.95 
                 9.33 
                 8.42 
                 −11.85 
               
               
                 FL_1857 
                 Validation 
                 10.35 
                 9.81 
                 9.28 
                 −11.50 
               
               
                 FL_1861 
                 Validation 
                 9.73 
                 9.46 
                 8.43 
                 −11.96 
               
               
                 FL_1862 
                 Validation 
                 10.42 
                 8.94 
                 8.22 
                 −11.69 
               
               
                 FL_1863 
                 Validation 
                 10.79 
                 9.29 
                 8.82 
                 −11.54 
               
               
                 FL_1864 
                 Training 
                 9.67 
                 9.97 
                 9.07 
                 −11.80 
               
               
                 FL_1866 
                 Training 
                 10.19 
                 9.88 
                 8.89 
                 −12.33 
               
               
                 FL_1870 
                 Validation 
                 9.78 
                 10.07 
                 9.30 
                 −11.63 
               
               
                 FL_1873 
                 Training 
                 10.09 
                 9.41 
                 8.77 
                 −11.40 
               
               
                 FL_1874 
                 Validation 
                 10.05 
                 9.33 
                 8.69 
                 −11.37 
               
               
                 FL_1876 
                 Validation 
                 10.15 
                 9.59 
                 8.67 
                 −12.08 
               
               
                 FL_1879 
                 Training 
                 9.73 
                 9.21 
                 8.58 
                 −11.06 
               
               
                 FL_1880 
                 Validation 
                 10.02 
                 8.79 
                 8.35 
                 −10.77 
               
               
                 FL_1882 
                 Training 
                 9.59 
                 9.44 
                 8.80 
                 −11.05 
               
               
                 FL_1884 
                 Validation 
                 9.76 
                 9.51 
                 9.26 
                 −10.38 
               
               
                 FL_1885 
                 Validation 
                 10.48 
                 9.66 
                 8.75 
                 −12.32 
               
               
                 FL_1887 
                 Training 
                 9.98 
                 9.42 
                 8.47 
                 −11.96 
               
               
                 FL_1888 
                 Training 
                 9.73 
                 9.83 
                 8.99 
                 −11.67 
               
               
                 FL_1890 
                 Training 
                 10.06 
                 9.33 
                 8.98 
                 −10.76 
               
               
                 FL_1894 
                 Training 
                 9.85 
                 8.99 
                 8.75 
                 −10.29 
               
               
                 FL_1896 
                 Training 
                 10.21 
                 9.80 
                 8.51 
                 −12.94 
               
               
                 FL_1897 
                 Training 
                 10.67 
                 8.99 
                 8.26 
                 −11.90 
               
               
                 FL_1898 
                 Training 
                 9.59 
                 8.77 
                 8.21 
                 −10.68 
               
               
                 FL_1900 
                 Validation 
                 10.12 
                 9.10 
                 8.10 
                 −12.08 
               
               
                 FL_1903 
                 Validation 
                 11.08 
                 8.99 
                 8.39 
                 −11.93 
               
               
                 FL_1904 
                 Validation 
                 10.20 
                 9.16 
                 8.30 
                 −11.87 
               
               
                 FL_1905 
                 Validation 
                 9.73 
                 9.21 
                 8.22 
                 −11.80 
               
               
                 FL_1906 
                 Training 
                 9.95 
                 8.15 
                 8.44 
                 −9.01 
               
               
                 FL_1907 
                 Validation 
                 10.12 
                 7.95 
                 7.99 
                 −9.62 
               
               
                 FL_1910 
                 Training 
                 11.03 
                 9.38 
                 8.74 
                 −12.10 
               
               
                 FL_1912 
                 Validation 
                 9.83 
                 9.38 
                 9.36 
                 −9.95 
               
               
                 FL_1913 
                 Training 
                 9.81 
                 9.75 
                 8.43 
                 −12.69 
               
               
                 FL_1916 
                 Validation 
                 9.83 
                 9.18 
                 8.40 
                 −11.43 
               
               
                 FL_1918 
                 Validation 
                 9.86 
                 9.52 
                 8.79 
                 −11.45 
               
               
                 FL_1919 
                 Training 
                 9.87 
                 9.53 
                 8.79 
                 −11.48 
               
               
                 FL_735 
                 Validation 
                 10.48 
                 8.73 
                 8.23 
                 −11.20 
               
               
                 FL_738 
                 Validation 
                 11.05 
                 9.10 
                 8.75 
                 −11.43 
               
               
                 FL_739 
                 Training 
                 9.66 
                 9.25 
                 8.74 
                 −10.78 
               
               
                 FL_878 
                 Validation 
                 10.61 
                 8.92 
                 8.65 
                 −10.89 
               
               
                 FL_879 
                 Training 
                 9.92 
                 8.94 
                 8.78 
                 −10.14 
               
               
                 FL_886 
                 Validation 
                 10.16 
                 9.41 
                 8.63 
                 −11.73 
               
               
                 FL_888 
                 Validation 
                 9.35 
                 8.76 
                 8.38 
                 −10.15 
               
               
                 FL_1627 
                 Training 
                 9.82 
                 9.48 
                 8.49 
                 −11.94 
               
               
                 FL_1429 
                 Training 
                 10.06 
                 8.70 
                 8.14 
                 −11.01 
               
               
                 FL_1850 
                 Validation 
                 9.58 
                 9.73 
                 8.70 
                 −11.93 
               
               
                 FL_1735 
                 Validation 
                 9.60 
                 7.46 
                 8.42 
                 −7.19 
               
               
                   
               
            
           
         
       
     
     In order to visualize the predictive power of the model, the FL samples were ranked according to their survival predictor scores and divided into four quartiles. Kaplan-Meier plots of overall survival showed clear differences in survival rate in the validation set ( FIG. 8 ). The median survival for each of the four quartiles is set forth in Table 2366. 
     
       
         
           
               
               
               
               
               
             
               
                   
                 TABLE 2366 
               
               
                   
                   
               
               
                   
                   
                 Median 
                 5-year 
                 10-year 
               
               
                   
                 Quartile 
                 survival (yrs.) 
                 survival 
                 survival 
               
               
                   
                   
               
             
            
               
                   
                 1 
                 NR 
                 94% 
                 79% 
               
               
                   
                 2 
                 11.6  
                 82% 
                 62% 
               
               
                   
                 3 
                 8.8 
                 69% 
                 39% 
               
               
                   
                 4 
                 3.9 
                 38% 
                 22% 
               
               
                   
                   
               
            
           
         
       
     
     Example 5 
     Development of a Third FL Survival Predictor Using Gene Expression Data from the Lymph Dx Microarray 
     191 FL samples were divided into two equivalent groups: a training set for developing the survival prediction model, and a validation set for evaluating the reproducibility of the model. Gene expression data from the Lymph Dx microarray was obtained for those genes listed in Table 2364, above. This gene expression data was used to calculate gene expression signature values for the macrophage, T-cell, and B-cell differentiation gene expression signatures, and these signature values were used to generate a survival predictor score using the following equation:
 
Survival predictor score=[1.51*(macrophage gene expression signature value)]−[2.11*(T-cell gene expression signature value)]−[0.505*(B-cell differentiation gene expression signature value)].
 
A higher survival predictor score was associated with worse outcome. For the 187 FL samples with available clinical data, the survival predictor score had a mean of −10.1 and a standard deviation of 0.69, with each unit increase in the predictor score corresponding to a 2.7 fold increase in the relative risk of death. Data for all 191 samples is shown in Table 2367.
 
     
       
         
           
               
               
               
               
               
               
             
               
                 TABLE 2367 
               
               
                   
               
               
                   
                   
                 B cell 
                 T-cell 
                 Macro- 
                   
               
               
                   
                   
                 differentiation 
                 sig- 
                 phage 
                 Survival 
               
               
                 Sample 
                   
                 signature 
                 nature 
                 signature 
                 predictor 
               
               
                 ID # 
                 Set 
                 value 
                 value 
                 value 
                 score 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 FL_1073 
                 Training 
                 8.26 
                 8.17 
                 7.36 
                 −10.30 
               
               
                 FL_1074 
                 Training 
                 9.53 
                 8.12 
                 7.56 
                 −10.53 
               
               
                 FL_1075 
                 Validation 
                 9.81 
                 8.00 
                 7.99 
                 −9.77 
               
               
                 FL_1076 
                 Training 
                 8.46 
                 8.10 
                 7.62 
                 −9.86 
               
               
                 FL_1077 
                 Training 
                 8.45 
                 8.66 
                 7.32 
                 −11.49 
               
               
                 FL_1078 
                 Training 
                 9.23 
                 8.32 
                 7.32 
                 −11.18 
               
               
                 FL_1080 
                 Training 
                 9.18 
                 8.37 
                 7.86 
                 −10.42 
               
               
                 FL_1081 
                 Validation 
                 8.96 
                 8.01 
                 6.94 
                 −10.96 
               
               
                 FL_1083 
                 Training 
                 8.72 
                 8.65 
                 7.89 
                 −10.75 
               
               
                 FL_1085 
                 Validation 
                 8.34 
                 8.17 
                 7.54 
                 −10.07 
               
               
                 FL_1086 
                 Validation 
                 8.50 
                 8.35 
                 7.94 
                 −9.94 
               
               
                 FL_1087 
                 Training 
                 8.02 
                 8.88 
                 8.48 
                 −10.00 
               
               
                 FL_1088 
                 Validation 
                 9.10 
                 8.15 
                 7.38 
                 −10.65 
               
               
                 FL_1089 
                 Training 
                 8.76 
                 8.31 
                 7.35 
                 −10.86 
               
               
                 FL_1090 
                 Validation 
                 8.18 
                 8.23 
                 7.43 
                 −10.28 
               
               
                 FL_1097 
                 Validation 
                 8.07 
                 8.81 
                 7.90 
                 −10.73 
               
               
                 FL_1098 
                 Validation 
                 9.53 
                 8.30 
                 8.09 
                 −10.11 
               
               
                 FL_1099 
                 Training 
                 8.44 
                 8.56 
                 8.26 
                 −9.86 
               
               
                 FL_1102 
                 Validation 
                 7.92 
                 8.43 
                 7.94 
                 −9.80 
               
               
                 FL_1104 
                 Training 
                 9.17 
                 8.07 
                 7.21 
                 −10.78 
               
               
                 FL_1106 
                 Validation 
                 9.71 
                 8.15 
                 8.77 
                 −8.85 
               
               
                 FL_1107 
                 Training 
                 8.16 
                 8.44 
                 8.60 
                 −8.95 
               
               
                 FL_1183 
                 Training 
                 8.49 
                 8.15 
                 7.23 
                 −10.56 
               
               
                 FL_1184 
                 Training 
                 8.81 
                 8.49 
                 7.91 
                 −10.43 
               
               
                 FL_1185 
                 Validation 
                 9.31 
                 8.19 
                 8.06 
                 −9.80 
               
               
                 FL_1186 
                 Training 
                 8.43 
                 7.87 
                 7.83 
                 −9.04 
               
               
                 FL_1416 
                 Validation 
                 8.42 
                 8.34 
                 7.63 
                 −10.34 
               
               
                 FL_1417 
                 Training 
                 8.65 
                 7.51 
                 7.05 
                 −9.58 
               
               
                 FL_1418 
                 Validation 
                 7.96 
                 7.82 
                 7.22 
                 −9.62 
               
               
                 FL_1419 
                 Training 
                 8.80 
                 8.71 
                 7.55 
                 −11.43 
               
               
                 FL_1422 
                 Training 
                 8.63 
                 8.35 
                 7.39 
                 −10.83 
               
               
                 FL_1425 
                 Validation 
                 8.21 
                 7.92 
                 7.62 
                 −9.36 
               
               
                 FL_1426 
                 Training 
                 9.39 
                 8.09 
                 7.15 
                 −11.01 
               
               
                 FL_1427 
                 Training 
                 8.66 
                 7.51 
                 7.00 
                 −9.65 
               
               
                 FL_1428 
                 Validation 
                 9.33 
                 8.18 
                 7.39 
                 −10.81 
               
               
                 FL_1432 
                 Training 
                 8.98 
                 8.17 
                 7.93 
                 −9.81 
               
               
                 FL_1436 
                 Training 
                 8.04 
                 8.17 
                 7.35 
                 −10.20 
               
               
                 FL_1440 
                 Training 
                 8.29 
                 7.82 
                 7.15 
                 −9.89 
               
               
                 FL_1445 
                 Training 
                 8.04 
                 7.78 
                 7.63 
                 −8.94 
               
               
                 FL_1450 
                 Validation 
                 8.25 
                 8.81 
                 9.52 
                 −8.39 
               
               
                 FL_1472 
                 Validation 
                 9.29 
                 7.88 
                 7.33 
                 −10.26 
               
               
                 FL_1473 
                 Training 
                 8.49 
                 8.57 
                 7.52 
                 −11.03 
               
               
                 FL_1474 
                 Validation 
                 8.59 
                 8.09 
                 8.53 
                 −8.54 
               
               
                 FL_1476 
                 Validation 
                 8.25 
                 8.39 
                 7.71 
                 −10.23 
               
               
                 FL_1477 
                 Training 
                 7.94 
                 8.57 
                 7.88 
                 −10.21 
               
               
                 FL_1478 
                 Training 
                 8.57 
                 8.40 
                 7.88 
                 −10.16 
               
               
                 FL_1479 
                 Training 
                 9.15 
                 7.83 
                 7.87 
                 −9.27 
               
               
                 FL_1480 
                 Training 
                 8.25 
                 8.38 
                 7.44 
                 −10.63 
               
               
                 FL_1579 
                 Training 
                 8.70 
                 7.73 
                 7.43 
                 −9.48 
               
               
                 FL_1580 
                 Training 
                 8.86 
                 8.46 
                 7.64 
                 −10.79 
               
               
                 FL_1581 
                 Training 
                 8.41 
                 7.89 
                 8.08 
                 −8.69 
               
               
                 FL_1582 
                 Validation 
                 8.20 
                 7.42 
                 6.99 
                 −9.24 
               
               
                 FL_1583 
                 Training 
                 9.34 
                 8.34 
                 7.94 
                 −10.32 
               
               
                 FL_1584 
                 Training 
                 8.50 
                 8.33 
                 7.75 
                 −10.17 
               
               
                 FL_1585 
                 Validation 
                 9.08 
                 7.96 
                 7.72 
                 −9.72 
               
               
                 FL_1586 
                 Validation 
                 8.52 
                 8.25 
                 7.36 
                 −10.61 
               
               
                 FL_1588 
                 Training 
                 7.97 
                 8.35 
                 7.73 
                 −9.98 
               
               
                 FL_1589 
                 Training 
                 8.85 
                 8.48 
                 7.76 
                 −10.66 
               
               
                 FL_1591 
                 Training 
                 8.92 
                 8.36 
                 7.77 
                 −10.42 
               
               
                 FL_1594 
                 Validation 
                 8.54 
                 8.22 
                 7.74 
                 −9.96 
               
               
                 FL_1595 
                 Training 
                 8.05 
                 8.82 
                 8.68 
                 −9.57 
               
               
                 FL_1598 
                 Validation 
                 9.74 
                 7.81 
                 6.97 
                 −10.88 
               
               
                 FL_1599 
                 Validation 
                 9.13 
                 8.42 
                 7.69 
                 −10.77 
               
               
                 FL_1603 
                 Training 
                 7.97 
                 8.66 
                 8.90 
                 −8.86 
               
               
                 FL_1604 
                 Training 
                 8.47 
                 8.14 
                 7.75 
                 −9.75 
               
               
                 FL_1606 
                 Validation 
                 8.34 
                 8.32 
                 8.11 
                 −9.51 
               
               
                 FL_1607 
                 Validation 
                 8.33 
                 8.30 
                 7.39 
                 −10.57 
               
               
                 FL_1608 
                 Validation 
                 8.35 
                 7.88 
                 6.98 
                 −10.31 
               
               
                 FL_1610 
                 Validation 
                 8.48 
                 8.35 
                 8.86 
                 −8.52 
               
               
                 FL_1611 
                 Validation 
                 8.54 
                 8.33 
                 7.64 
                 −10.37 
               
               
                 FL_1616 
                 Training 
                 8.03 
                 8.39 
                 7.67 
                 −10.18 
               
               
                 FL_1617 
                 Validation 
                 8.30 
                 7.85 
                 7.52 
                 −9.40 
               
               
                 FL_1619 
                 Validation 
                 8.53 
                 8.31 
                 7.64 
                 −10.32 
               
               
                 FL_1620 
                 Validation 
                 8.09 
                 7.99 
                 7.17 
                 −10.11 
               
               
                 FL_1622 
                 Training 
                 8.14 
                 8.10 
                 7.36 
                 −10.09 
               
               
                 FL_1623 
                 Training 
                 8.45 
                 8.52 
                 8.15 
                 −9.93 
               
               
                 FL_1624 
                 Validation 
                 9.13 
                 8.12 
                 7.46 
                 −10.49 
               
               
                 FL_1625 
                 Validation 
                 8.53 
                 7.94 
                 7.17 
                 −10.23 
               
               
                 FL_1626 
                 Validation 
                 9.63 
                 7.67 
                 7.17 
                 −10.22 
               
               
                 FL_1628 
                 Validation 
                 8.63 
                 8.76 
                 7.95 
                 −10.86 
               
               
                 FL_1637 
                 Validation 
                 8.07 
                 8.81 
                 8.79 
                 −9.38 
               
               
                 FL_1638 
                 Validation 
                 8.52 
                 8.18 
                 8.19 
                 −9.18 
               
               
                 FL_1639 
                 Training 
                 8.70 
                 8.33 
                 7.89 
                 −10.06 
               
               
                 FL_1643 
                 Training 
                 8.26 
                 8.62 
                 8.01 
                 −10.26 
               
               
                 FL_1644 
                 Validation 
                 8.28 
                 8.33 
                 7.77 
                 −10.02 
               
               
                 FL_1645 
                 Training 
                 7.84 
                 8.32 
                 7.68 
                 −9.91 
               
               
                 FL_1646 
                 Training 
                 8.40 
                 8.26 
                 7.71 
                 −10.01 
               
               
                 FL_1647 
                 Training 
                 8.10 
                 8.04 
                 7.92 
                 −9.10 
               
               
                 FL_1648 
                 Training 
                 8.33 
                 8.08 
                 6.87 
                 −10.90 
               
               
                 FL_1652 
                 Training 
                 8.15 
                 8.33 
                 8.37 
                 −9.07 
               
               
                 FL_1654 
                 Validation 
                 8.67 
                 7.62 
                 7.03 
                 −9.85 
               
               
                 FL_1655 
                 Training 
                 8.53 
                 8.41 
                 7.75 
                 −10.36 
               
               
                 FL_1656 
                 Validation 
                 9.09 
                 8.09 
                 7.62 
                 −10.16 
               
               
                 FL_1657 
                 Training 
                 8.95 
                 8.44 
                 7.58 
                 −10.89 
               
               
                 FL_1660 
                 Training 
                 8.82 
                 7.79 
                 7.26 
                 −9.93 
               
               
                 FL_1661 
                 Validation 
                 8.56 
                 8.79 
                 8.17 
                 −10.53 
               
               
                 FL_1662 
                 Validation 
                 8.30 
                 8.47 
                 8.69 
                 −8.93 
               
               
                 FL_1664 
                 Validation 
                 8.62 
                 8.23 
                 7.56 
                 −10.31 
               
               
                 FL_1669 
                 Training 
                 7.89 
                 7.67 
                 7.39 
                 −9.02 
               
               
                 FL_1670 
                 Training 
                 8.01 
                 8.54 
                 8.64 
                 −9.03 
               
               
                 FL_1675 
                 Training 
                 9.00 
                 8.21 
                 7.36 
                 −10.76 
               
               
                 FL_1681 
                 Validation 
                 8.83 
                 8.39 
                 7.59 
                 −10.72 
               
               
                 FL_1683 
                 Validation 
                 8.14 
                 8.85 
                 7.97 
                 −10.74 
               
               
                 FL_1684 
                 Training 
                 7.99 
                 8.42 
                 7.84 
                 −9.97 
               
               
                 FL_1716 
                 Validation 
                 8.28 
                 7.90 
                 7.26 
                 −9.88 
               
               
                 FL_1717 
                 Validation 
                 8.27 
                 8.21 
                 7.89 
                 −9.60 
               
               
                 FL_1718 
                 Training 
                 8.50 
                 8.17 
                 7.15 
                 −10.75 
               
               
                 FL_1719 
                 Validation 
                 8.35 
                 8.02 
                 7.21 
                 −10.26 
               
               
                 FL_1720 
                 Training 
                 9.03 
                 7.65 
                 8.01 
                 −8.61 
               
               
                 FL_1729 
                 Training 
                 8.97 
                 8.27 
                 7.69 
                 −10.37 
               
               
                 FL_1732 
                 Validation 
                 8.49 
                 6.82 
                 7.71 
                 −7.02 
               
               
                 FL_1761 
                 Validation 
                 8.36 
                 8.19 
                 7.29 
                 −10.49 
               
               
                 FL_1764 
                 Training 
                 8.52 
                 8.24 
                 7.94 
                 −9.69 
               
               
                 FL_1768 
                 Training 
                 8.70 
                 8.25 
                 7.63 
                 −10.28 
               
               
                 FL_1771 
                 Training 
                 8.55 
                 8.19 
                 7.65 
                 −10.04 
               
               
                 FL_1772 
                 Validation 
                 8.30 
                 8.38 
                 7.41 
                 −10.71 
               
               
                 FL_1788 
                 Training 
                 8.14 
                 8.06 
                 8.11 
                 −8.87 
               
               
                 FL_1790 
                 Training 
                 7.95 
                 8.69 
                 8.36 
                 −9.74 
               
               
                 FL_1792 
                 Validation 
                 8.16 
                 8.20 
                 7.64 
                 −9.88 
               
               
                 FL_1795 
                 Training 
                 7.94 
                 9.08 
                 8.37 
                 −10.54 
               
               
                 FL_1797 
                 Validation 
                 8.17 
                 8.21 
                 7.87 
                 −9.57 
               
               
                 FL_1799 
                 Training 
                 9.02 
                 8.21 
                 7.77 
                 −10.14 
               
               
                 FL_1810 
                 Validation 
                 8.43 
                 7.52 
                 7.06 
                 −9.47 
               
               
                 FL_1811 
                 Validation 
                 8.33 
                 8.24 
                 7.07 
                 −10.93 
               
               
                 FL_1825 
                 Training 
                 8.90 
                 8.39 
                 7.97 
                 −10.18 
               
               
                 FL_1827 
                 Training 
                 8.47 
                 8.77 
                 7.96 
                 −10.76 
               
               
                 FL_1828 
                 Validation 
                 9.13 
                 7.87 
                 6.76 
                 −11.01 
               
               
                 FL_1829 
                 Validation 
                 8.34 
                 8.51 
                 7.59 
                 −10.71 
               
               
                 FL_1830 
                 Validation 
                 9.26 
                 8.04 
                 7.62 
                 −10.13 
               
               
                 FL_1833 
                 Training 
                 8.82 
                 8.86 
                 7.88 
                 −11.26 
               
               
                 FL_1834 
                 Validation 
                 9.25 
                 8.17 
                 7.62 
                 −10.39 
               
               
                 FL_1835 
                 Validation 
                 7.71 
                 8.16 
                 8.01 
                 −9.02 
               
               
                 FL_1836 
                 Validation 
                 9.06 
                 8.52 
                 7.59 
                 −11.09 
               
               
                 FL_1837 
                 Validation 
                 8.57 
                 8.33 
                 7.37 
                 −10.79 
               
               
                 FL_1838 
                 Validation 
                 8.78 
                 8.72 
                 8.04 
                 −10.69 
               
               
                 FL_1839 
                 Training 
                 9.27 
                 7.36 
                 7.37 
                 −9.08 
               
               
                 FL_1841 
                 Training 
                 8.66 
                 8.35 
                 8.17 
                 −9.64 
               
               
                 FL_1842 
                 Validation 
                 8.62 
                 8.50 
                 8.02 
                 −10.19 
               
               
                 FL_1844 
                 Validation 
                 9.37 
                 8.40 
                 7.47 
                 −11.18 
               
               
                 FL_1845 
                 Training 
                 8.33 
                 8.84 
                 8.30 
                 −10.32 
               
               
                 FL_1846 
                 Validation 
                 8.11 
                 8.75 
                 9.06 
                 −8.89 
               
               
                 FL_1848 
                 Training 
                 8.19 
                 8.60 
                 7.91 
                 −10.33 
               
               
                 FL_1851 
                 Training 
                 8.37 
                 8.50 
                 8.15 
                 −9.84 
               
               
                 FL_1853 
                 Validation 
                 8.37 
                 8.14 
                 7.43 
                 −10.19 
               
               
                 FL_1854 
                 Validation 
                 8.50 
                 8.29 
                 7.96 
                 −9.78 
               
               
                 FL_1855 
                 Validation 
                 8.63 
                 8.34 
                 7.54 
                 −10.58 
               
               
                 FL_1857 
                 Validation 
                 8.73 
                 8.82 
                 8.45 
                 −10.26 
               
               
                 FL_1861 
                 Validation 
                 8.21 
                 8.50 
                 7.50 
                 −10.77 
               
               
                 FL_1862 
                 Validation 
                 8.98 
                 7.96 
                 7.31 
                 −10.28 
               
               
                 FL_1863 
                 Validation 
                 9.30 
                 8.22 
                 7.86 
                 −10.18 
               
               
                 FL_1864 
                 Training 
                 8.13 
                 8.93 
                 8.27 
                 −10.46 
               
               
                 FL_1866 
                 Training 
                 8.62 
                 8.78 
                 7.91 
                 −10.93 
               
               
                 FL_1870 
                 Validation 
                 8.16 
                 8.97 
                 8.52 
                 −10.18 
               
               
                 FL_1873 
                 Training 
                 8.55 
                 8.30 
                 8.00 
                 −9.74 
               
               
                 FL_1874 
                 Validation 
                 8.43 
                 8.20 
                 7.59 
                 −10.10 
               
               
                 FL_1876 
                 Validation 
                 8.48 
                 8.52 
                 7.70 
                 −10.64 
               
               
                 FL_1879 
                 Training 
                 8.29 
                 8.21 
                 7.66 
                 −9.94 
               
               
                 FL_1880 
                 Validation 
                 8.56 
                 7.76 
                 7.34 
                 −9.61 
               
               
                 FL_1882 
                 Training 
                 8.02 
                 8.40 
                 7.71 
                 −10.14 
               
               
                 FL_1884 
                 Validation 
                 8.14 
                 8.46 
                 8.42 
                 −9.24 
               
               
                 FL_1885 
                 Validation 
                 8.88 
                 8.57 
                 7.78 
                 −10.81 
               
               
                 FL_1887 
                 Training 
                 8.38 
                 8.39 
                 7.38 
                 −10.78 
               
               
                 FL_1888 
                 Training 
                 8.14 
                 8.74 
                 8.07 
                 −10.37 
               
               
                 FL_1890 
                 Training 
                 8.45 
                 8.24 
                 8.11 
                 −9.41 
               
               
                 FL_1894 
                 Training 
                 8.38 
                 7.97 
                 7.82 
                 −9.25 
               
               
                 FL_1896 
                 Training 
                 8.63 
                 8.71 
                 7.52 
                 −11.37 
               
               
                 FL_1897 
                 Training 
                 9.01 
                 7.91 
                 6.93 
                 −10.78 
               
               
                 FL_1898 
                 Training 
                 8.08 
                 7.75 
                 7.09 
                 −9.74 
               
               
                 FL_1900 
                 Validation 
                 8.61 
                 7.94 
                 6.84 
                 −10.77 
               
               
                 FL_1903 
                 Validation 
                 9.63 
                 7.96 
                 7.30 
                 −10.64 
               
               
                 FL_1904 
                 Validation 
                 8.79 
                 8.14 
                 7.15 
                 −10.82 
               
               
                 FL_1905 
                 Validation 
                 8.22 
                 8.24 
                 7.36 
                 −10.43 
               
               
                 FL_1906 
                 Training 
                 8.40 
                 7.40 
                 7.24 
                 −8.93 
               
               
                 FL_1907 
                 Validation 
                 8.61 
                 7.11 
                 6.59 
                 −9.40 
               
               
                 FL_1910 
                 Training 
                 9.47 
                 8.28 
                 7.63 
                 −10.73 
               
               
                 FL_1912 
                 Validation 
                 8.32 
                 8.45 
                 8.52 
                 −9.18 
               
               
                 FL_1913 
                 Training 
                 8.24 
                 8.60 
                 7.23 
                 −11.41 
               
               
                 FL_1916 
                 Validation 
                 8.31 
                 8.04 
                 7.27 
                 −10.19 
               
               
                 FL_1918 
                 Validation 
                 8.30 
                 8.49 
                 7.78 
                 −10.37 
               
               
                 FL_1919 
                 Training 
                 8.05 
                 8.42 
                 8.00 
                 −9.75 
               
               
                 FL_735 
                 Validation 
                 9.03 
                 7.83 
                 7.41 
                 −9.88 
               
               
                 FL_738 
                 Validation 
                 9.54 
                 8.07 
                 7.65 
                 −10.30 
               
               
                 FL_739 
                 Training 
                 8.14 
                 8.09 
                 7.69 
                 −9.57 
               
               
                 FL_878 
                 Validation 
                 9.17 
                 7.91 
                 7.70 
                 −9.69 
               
               
                 FL_879 
                 Training 
                 8.37 
                 7.96 
                 7.67 
                 −9.45 
               
               
                 FL_886 
                 Validation 
                 8.59 
                 8.38 
                 7.67 
                 −10.44 
               
               
                 FL_888 
                 Validation 
                 7.85 
                 7.71 
                 7.07 
                 −9.56 
               
               
                 FL_1627 
                 Training 
                 8.26 
                 8.17 
                 7.36 
                 −10.30 
               
               
                 FL_1429 
                 Training 
                 9.53 
                 8.12 
                 7.56 
                 −10.53 
               
               
                 FL_1850 
                 Validation 
                 9.81 
                 8.00 
                 7.99 
                 −9.77 
               
               
                 FL_1735 
                 Validation 
                 8.46 
                 8.10 
                 7.62 
                 −9.86 
               
               
                   
               
            
           
         
       
     
     In order to visualize the predictive power of the model, the FL samples were ranked according to their survival predictor scores and divided into four quartiles. Kaplan-Meier plots of overall survival showed clear differences in survival rate in the validation set ( FIG. 9 ). 
     Example 6 
     Development of a First DLBCL Survival Predictor Using Gene Expression Data from Affymetrix U133A and U133B Microarrays 
     Gene expression data from Affymetrix U133A and U133B microarrays was obtained for 231 DLBCL samples. The follow-up time and status at follow-up for each of the subjects from whom these samples were acquired is listed in Table 2368. Table 2368 also indicates which samples were used in creating the survival predictor. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 2368 
               
               
                   
               
               
                   
                   
                   
                 Used in 
               
               
                   
                 Length of follow- 
                 Status at 
                 creating survival 
               
               
                 Sample ID # 
                 up (years) 
                 follow-up 
                 predictor? 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 ABC_1000 
                 0.69 
                 Dead 
                 Yes 
               
               
                 ABC_1002 
                 0.28 
                 Dead 
                 Yes 
               
               
                 ABC_1023 
                 5.57 
                 Dead 
                 Yes 
               
               
                 ABC_1027 
                 0.25 
                 Dead 
                 Yes 
               
               
                 ABC_1031 
                 6.64 
                 Dead 
                 Yes 
               
               
                 ABC_1034 
                 2.31 
                 Dead 
                 Yes 
               
               
                 ABC_1038 
                 0.71 
                 Dead 
                 Yes 
               
               
                 ABC_1043 
                 2.31 
                 Dead 
                 Yes 
               
               
                 ABC_1045 
                 2.26 
                 Dead 
                 Yes 
               
               
                 ABC_1055 
                 7.81 
                 Alive 
                 Yes 
               
               
                 ABC_1057 
                 2.13 
                 Dead 
                 Yes 
               
               
                 ABC_1059 
                 2.00 
                 Dead 
                 Yes 
               
               
                 ABC_1061 
                 1.04 
                 Dead 
                 Yes 
               
               
                 ABC_1946 
                 0.68 
                 Dead 
                 No 
               
               
                 ABC_1994 
                 1.21 
                 Dead 
                 No 
               
               
                 ABC_2001 
                 1.32 
                 Dead 
                 No 
               
               
                 ABC_304 
                 1.31 
                 Dead 
                 Yes 
               
               
                 ABC_305 
                 0.82 
                 Alive 
                 Yes 
               
               
                 ABC_309 
                 2.80 
                 Alive 
                 Yes 
               
               
                 ABC_413 
                 0.60 
                 Dead 
                 Yes 
               
               
                 ABC_428 
                 11.38 
                 Alive 
                 Yes 
               
               
                 ABC_432 
                 0.38 
                 Dead 
                 Yes 
               
               
                 ABC_446 
                 2.82 
                 Dead 
                 Yes 
               
               
                 ABC_462 
                 7.49 
                 Dead 
                 Yes 
               
               
                 ABC_477 
                 1.70 
                 Dead 
                 Yes 
               
               
                 ABC_481 
                 10.75 
                 Alive 
                 Yes 
               
               
                 ABC_482 
                 7.72 
                 Alive 
                 Yes 
               
               
                 ABC_538 
                 0.34 
                 Dead 
                 Yes 
               
               
                 ABC_541 
                 4.11 
                 Alive 
                 Yes 
               
               
                 ABC_544 
                 1.31 
                 Dead 
                 Yes 
               
               
                 ABC_547 
                 0.05 
                 Dead 
                 Yes 
               
               
                 ABC_577 
                 1.65 
                 Alive 
                 Yes 
               
               
                 ABC_616 
                 0.99 
                 Dead 
                 Yes 
               
               
                 ABC_626 
                 2.49 
                 Dead 
                 Yes 
               
               
                 ABC_633 
                 2.02 
                 Alive 
                 Yes 
               
               
                 ABC_642 
                 0.34 
                 Dead 
                 Yes 
               
               
                 ABC_644 
                 0.31 
                 Dead 
                 Yes 
               
               
                 ABC_645 
                 6.08 
                 Dead 
                 Yes 
               
               
                 ABC_646 
                 2.59 
                 Dead 
                 Yes 
               
               
                 ABC_651 
                 2.34 
                 Alive 
                 Yes 
               
               
                 ABC_652 
                 0.01 
                 Dead 
                 Yes 
               
               
                 ABC_660 
                 0.20 
                 Dead 
                 Yes 
               
               
                 ABC_663 
                 0.62 
                 Dead 
                 Yes 
               
               
                 ABC_668 
                 6.44 
                 Alive 
                 Yes 
               
               
                 ABC_676 
                 1.00 
                 Dead 
                 Yes 
               
               
                 ABC_678 
                 0.06 
                 Dead 
                 Yes 
               
               
                 ABC_687 
                 0.94 
                 Dead 
                 Yes 
               
               
                 ABC_689 
                 2.54 
                 Dead 
                 Yes 
               
               
                 ABC_692 
                 10.53 
                 Alive 
                 Yes 
               
               
                 ABC_694 
                 4.83 
                 Alive 
                 Yes 
               
               
                 ABC_700 
                 5.40 
                 Dead 
                 Yes 
               
               
                 ABC_702 
                 4.13 
                 Dead 
                 Yes 
               
               
                 ABC_704 
                 9.67 
                 Alive 
                 Yes 
               
               
                 ABC_709 
                 0.47 
                 Dead 
                 Yes 
               
               
                 ABC_712 
                 3.26 
                 Dead 
                 Yes 
               
               
                 ABC_714 
                 2.45 
                 Dead 
                 Yes 
               
               
                 ABC_717 
                 0.42 
                 Dead 
                 Yes 
               
               
                 ABC_725 
                 0.96 
                 Dead 
                 Yes 
               
               
                 ABC_726 
                 7.62 
                 Alive 
                 Yes 
               
               
                 ABC_730 
                 1.03 
                 Dead 
                 Yes 
               
               
                 ABC_753 
                 0.04 
                 Dead 
                 Yes 
               
               
                 ABC_756 
                 7.21 
                 Alive 
                 Yes 
               
               
                 ABC_771 
                 6.80 
                 Dead 
                 Yes 
               
               
                 ABC_779 
                 0.35 
                 Dead 
                 Yes 
               
               
                 ABC_800 
                 0.33 
                 Dead 
                 Yes 
               
               
                 ABC_807 
                 0.31 
                 Dead 
                 Yes 
               
               
                 ABC_809 
                 0.51 
                 Dead 
                 Yes 
               
               
                 ABC_816 
                 1.86 
                 Dead 
                 Yes 
               
               
                 ABC_820 
                 1.59 
                 Dead 
                 Yes 
               
               
                 ABC_823 
                 0.16 
                 Dead 
                 Yes 
               
               
                 ABC_835 
                 1.22 
                 Dead 
                 Yes 
               
               
                 ABC_839 
                 0.29 
                 Dead 
                 Yes 
               
               
                 ABC_841 
                 10.14 
                 Alive 
                 Yes 
               
               
                 ABC_858 
                 3.58 
                 Dead 
                 Yes 
               
               
                 ABC_872 
                 5.00 
                 Alive 
                 Yes 
               
               
                 ABC_875 
                 8.45 
                 Alive 
                 Yes 
               
               
                 ABC_912 
                 16.79 
                 Alive 
                 Yes 
               
               
                 ABC_996 
                 0.21 
                 Dead 
                 Yes 
               
               
                 GCB_1005 
                 5.77 
                 Alive 
                 Yes 
               
               
                 GCB_1008 
                 6.46 
                 Alive 
                 Yes 
               
               
                 GCB_1009 
                 9.68 
                 Alive 
                 Yes 
               
               
                 GCB_1021 
                 14.59 
                 Alive 
                 Yes 
               
               
                 GCB_1025 
                 2.86 
                 Dead 
                 Yes 
               
               
                 GCB_1026 
                 6.94 
                 Dead 
                 Yes 
               
               
                 GCB_1037 
                 0.23 
                 Dead 
                 Yes 
               
               
                 GCB_1039 
                 2.05 
                 Dead 
                 Yes 
               
               
                 GCB_1049 
                 1.33 
                 Dead 
                 Yes 
               
               
                 GCB_1051 
                 0.12 
                 Dead 
                 Yes 
               
               
                 GCB_1058 
                 0.42 
                 Dead 
                 Yes 
               
               
                 GCB_1060 
                 6.45 
                 Alive 
                 Yes 
               
               
                 GCB_1990 
                 0.06 
                 Dead 
                 No 
               
               
                 GCB_1991 
                 1.01 
                 Dead 
                 No 
               
               
                 GCB_2017 
                 0.08 
                 Dead 
                 No 
               
               
                 GCB_2018 
                 0.17 
                 Dead 
                 No 
               
               
                 GCB_2095 
                 0.97 
                 Alive 
                 No 
               
               
                 GCB_412 
                 12.12 
                 Alive 
                 Yes 
               
               
                 GCB_415 
                 5.38 
                 Dead 
                 Yes 
               
               
                 GCB_421 
                 1.24 
                 Dead 
                 Yes 
               
               
                 GCB_424 
                 10.62 
                 Dead 
                 Yes 
               
               
                 GCB_433 
                 0.76 
                 Dead 
                 Yes 
               
               
                 GCB_434 
                 10.53 
                 Alive 
                 Yes 
               
               
                 GCB_438 
                 8.15 
                 Alive 
                 Yes 
               
               
                 GCB_459 
                 9.65 
                 Alive 
                 Yes 
               
               
                 GCB_470 
                 11.17 
                 Alive 
                 Yes 
               
               
                 GCB_479 
                 7.24 
                 Alive 
                 Yes 
               
               
                 GCB_492 
                 11.29 
                 Alive 
                 Yes 
               
               
                 GCB_517 
                 3.03 
                 Dead 
                 Yes 
               
               
                 GCB_523 
                 8.36 
                 Alive 
                 Yes 
               
               
                 GCB_524 
                 5.88 
                 Alive 
                 Yes 
               
               
                 GCB_529 
                 1.06 
                 Dead 
                 Yes 
               
               
                 GCB_533 
                 0.71 
                 Dead 
                 Yes 
               
               
                 GCB_537 
                 4.99 
                 Dead 
                 Yes 
               
               
                 GCB_543 
                 3.47 
                 Alive 
                 Yes 
               
               
                 GCB_545 
                 1.10 
                 Dead 
                 Yes 
               
               
                 GCB_549 
                 2.68 
                 Dead 
                 Yes 
               
               
                 GCB_550 
                 21.78 
                 Alive 
                 Yes 
               
               
                 GCB_553 
                 0.82 
                 Dead 
                 Yes 
               
               
                 GCB_565 
                 9.11 
                 Dead 
                 Yes 
               
               
                 GCB_572 
                 14.24 
                 Alive 
                 Yes 
               
               
                 GCB_617 
                 5.88 
                 Alive 
                 Yes 
               
               
                 GCB_618 
                 5.65 
                 Alive 
                 Yes 
               
               
                 GCB_619 
                 8.76 
                 Alive 
                 Yes 
               
               
                 GCB_623 
                 2.43 
                 Alive 
                 Yes 
               
               
                 GCB_627 
                 1.27 
                 Dead 
                 Yes 
               
               
                 GCB_654 
                 7.37 
                 Alive 
                 Yes 
               
               
                 GCB_661 
                 0.56 
                 Alive 
                 Yes 
               
               
                 GCB_669 
                 7.11 
                 Alive 
                 Yes 
               
               
                 GCB_672 
                 6.78 
                 Alive 
                 Yes 
               
               
                 GCB_674 
                 7.22 
                 Alive 
                 Yes 
               
               
                 GCB_675 
                 6.02 
                 Alive 
                 Yes 
               
               
                 GCB_681 
                 9.70 
                 Alive 
                 Yes 
               
               
                 GCB_688 
                 0.33 
                 Dead 
                 Yes 
               
               
                 GCB_695 
                 0.15 
                 Dead 
                 Yes 
               
               
                 GCB_698 
                 3.88 
                 Alive 
                 Yes 
               
               
                 GCB_701 
                 3.90 
                 Alive 
                 Yes 
               
               
                 GCB_710 
                 1.08 
                 Dead 
                 Yes 
               
               
                 GCB_711 
                 3.93 
                 Dead 
                 Yes 
               
               
                 GCB_722 
                 3.32 
                 Alive 
                 Yes 
               
               
                 GCB_724 
                 1.40 
                 Dead 
                 Yes 
               
               
                 GCB_731 
                 10.18 
                 Alive 
                 Yes 
               
               
                 GCB_742 
                 4.09 
                 Alive 
                 Yes 
               
               
                 GCB_744 
                 8.86 
                 Alive 
                 Yes 
               
               
                 GCB_745 
                 1.33 
                 Dead 
                 Yes 
               
               
                 GCB_747 
                 15.41 
                 Alive 
                 Yes 
               
               
                 GCB_749 
                 10.40 
                 Alive 
                 Yes 
               
               
                 GCB_758 
                 1.10 
                 Dead 
                 Yes 
               
               
                 GCB_772 
                 2.48 
                 Alive 
                 Yes 
               
               
                 GCB_777 
                 4.27 
                 Dead 
                 Yes 
               
               
                 GCB_792 
                 5.53 
                 Alive 
                 Yes 
               
               
                 GCB_795 
                 3.43 
                 Alive 
                 Yes 
               
               
                 GCB_797 
                 6.87 
                 Dead 
                 Yes 
               
               
                 GCB_803 
                 1.45 
                 Dead 
                 Yes 
               
               
                 GCB_810 
                 11.72 
                 Alive 
                 Yes 
               
               
                 GCB_817 
                 2.76 
                 Dead 
                 Yes 
               
               
                 GCB_818 
                 0.10 
                 Dead 
                 Yes 
               
               
                 GCB_819 
                 0.72 
                 Dead 
                 Yes 
               
               
                 GCB_821 
                 9.47 
                 Alive 
                 Yes 
               
               
                 GCB_832 
                 4.01 
                 Alive 
                 Yes 
               
               
                 GCB_836 
                 4.29 
                 Alive 
                 Yes 
               
               
                 GCB_840 
                 3.40 
                 Alive 
                 Yes 
               
               
                 GCB_847 
                 4.16 
                 Alive 
                 Yes 
               
               
                 GCB_860 
                 3.03 
                 Dead 
                 Yes 
               
               
                 GCB_871 
                 0.41 
                 Dead 
                 Yes 
               
               
                 GCB_874 
                 0.12 
                 Dead 
                 Yes 
               
               
                 GCB_995 
                 6.65 
                 Alive 
                 Yes 
               
               
                 PMBL_1006 
                 7.12 
                 Alive 
                 Yes 
               
               
                 PMBL_1024 
                 19.83 
                 Alive 
                 Yes 
               
               
                 PMBL_1048 
                 7.70 
                 Alive 
                 Yes 
               
               
                 PMBL_1053 
                 1.04 
                 Dead 
                 Yes 
               
               
                 PMBL_1920 
                 1.97 
                 Alive 
                 No 
               
               
                 PMBL_1921 
                 4.16 
                 Alive 
                 No 
               
               
                 PMBL_1923 
                 1.60 
                 Alive 
                 No 
               
               
                 PMBL_1924 
                 6.11 
                 Alive 
                 No 
               
               
                 PMBL_1935 
                 12.42 
                 Alive 
                 No 
               
               
                 PMBL_1941 
                 0.71 
                 Alive 
                 No 
               
               
                 PMBL_1942 
                 0.88 
                 Alive 
                 No 
               
               
                 PMBL_1943 
                 8.96 
                 Alive 
                 No 
               
               
                 PMBL_1945 
                 0.84 
                 Dead 
                 No 
               
               
                 PMBL_1948 
                 7.96 
                 Alive 
                 No 
               
               
                 PMBL_1949 
                 4.28 
                 Alive 
                 No 
               
               
                 PMBL_1989 
                 1.33 
                 Dead 
                 No 
               
               
                 PMBL_1992 
                 1.00 
                 Dead 
                 No 
               
               
                 PMBL_1993 
                 1.33 
                 Dead 
                 No 
               
               
                 PMBL_2002 
                 6.62 
                 Alive 
                 No 
               
               
                 PMBL_2019 
                 0.99 
                 Dead 
                 No 
               
               
                 PMBL_2020 
                 2.08 
                 Alive 
                 No 
               
               
                 PMBL_2092 
                 1.27 
                 Alive 
                 No 
               
               
                 PMBL_484 
                 1.40 
                 Dead 
                 Yes 
               
               
                 PMBL_546 
                 0.78 
                 Dead 
                 Yes 
               
               
                 PMBL_570 
                 14.40 
                 Alive 
                 Yes 
               
               
                 PMBL_621 
                 8.14 
                 Alive 
                 Yes 
               
               
                 PMBL_638 
                 0.70 
                 Dead 
                 Yes 
               
               
                 PMBL_691 
                 0.32 
                 Dead 
                 Yes 
               
               
                 PMBL_791 
                 1.33 
                 Dead 
                 Yes 
               
               
                 PMBL_824 
                 12.24 
                 Alive 
                 Yes 
               
               
                 PMBL_906 
                 16.80 
                 Alive 
                 Yes 
               
               
                 PMBL_994 
                 4.79 
                 Alive 
                 Yes 
               
               
                 PMBL_998 
                 9.11 
                 Alive 
                 Yes 
               
               
                 UC_DLBCL_1001 
                 0.33 
                 Dead 
                 Yes 
               
               
                 UC_DLBCL_1004 
                 6.72 
                 Alive 
                 Yes 
               
               
                 UC_DLBCL_1007 
                 2.26 
                 Dead 
                 Yes 
               
               
                 UC_DLBCL_1018 
                 0.03 
                 Dead 
                 Yes 
               
               
                 UC_DLBCL_1041 
                 3.13 
                 Dead 
                 Yes 
               
               
                 UC_DLBCL_1054 
                 12.34 
                 Alive 
                 Yes 
               
               
                 UC_DLBCL_306 
                 2.69 
                 Alive 
                 Yes 
               
               
                 UC_DLBCL_310 
                 0.97 
                 Alive 
                 Yes 
               
               
                 UC_DLBCL_449 
                 9.16 
                 Alive 
                 Yes 
               
               
                 UC_DLBCL_452 
                 9.17 
                 Alive 
                 Yes 
               
               
                 UC_DLBCL_458 
                 1.18 
                 Dead 
                 Yes 
               
               
                 UC_DLBCL_460 
                 9.02 
                 Alive 
                 Yes 
               
               
                 UC_DLBCL_491 
                 4.47 
                 Dead 
                 Yes 
               
               
                 UC_DLBCL_528 
                 1.64 
                 Alive 
                 Yes 
               
               
                 UC_DLBCL_615 
                 4.94 
                 Alive 
                 Yes 
               
               
                 UC_DLBCL_625 
                 5.24 
                 Alive 
                 Yes 
               
               
                 UC_DLBCL_664 
                 0.62 
                 Dead 
                 Yes 
               
               
                 UC_DLBCL_671 
                 3.35 
                 Alive 
                 Yes 
               
               
                 UC_DLBCL_682 
                 0.11 
                 Dead 
                 Yes 
               
               
                 UC_DLBCL_683 
                 7.42 
                 Alive 
                 Yes 
               
               
                 UC_DLBCL_684 
                 1.92 
                 Dead 
                 Yes 
               
               
                 UC_DLBCL_748 
                 1.01 
                 Dead 
                 Yes 
               
               
                 UC_DLBCL_751 
                 9.99 
                 Alive 
                 Yes 
               
               
                 UC_DLBCL_808 
                 0.37 
                 Dead 
                 Yes 
               
               
                 UC_DLBCL_831 
                 11.02 
                 Dead 
                 Yes 
               
               
                 UC_DLBCL_834 
                 1.64 
                 Dead 
                 Yes 
               
               
                 UC_DLBCL_838 
                 0.00 
                 Dead 
                 Yes 
               
               
                 UC_DLBCL_851 
                 0.05 
                 Dead 
                 Yes 
               
               
                 UC_DLBCL_854 
                 1.51 
                 Dead 
                 Yes 
               
               
                 UC_DLBCL_855 
                 1.67 
                 Alive 
                 Yes 
               
               
                 UC_DLBCL_856 
                 0.60 
                 Dead 
                 Yes 
               
               
                   
               
            
           
         
       
     
     The correlation between expression of each gene represented on the microarrays and survival was estimated using a Cox proportional hazards model. The results of this survival analysis are provided in the final two columns of Table 1723. The first of these two columns (“DLBCL_Cox_coefficient”) provides a Cox coefficient indicating the extent to which a 2-fold increase in expression of a particular gene affects mortality. A positive Cox coefficient indicates increasing mortality with increasing expression of the gene, while a negative Cox coefficient indicates decreasing mortality with increasing expression of the gene. The second of these two columns (“DLBCL_Cox_P_value”) provides a Cox p-value indicating the estimated probability that the increase or decrease in survival associated with the gene would occur by chance if there was no connection between the expression of the gene and survival. 
     Genes that were significantly correlated with survival (p&lt;0.001) were grouped into gene expression signatures using a hierarchical clustering algorithm. The expression level of every component gene in each of these gene expression signatures was averaged for each sample to create a gene expression signature value. A step-up procedure (Drapner 1966) was applied to determine the optimal number of gene signatures to use in the survival predictor model. First, the gene expression signature that was most significantly associated with survival was included in the model. Next, the gene expression signature with the second highest association with survival was added to the model to form a two-component model. This procedure was repeated until there was no gene expression signature to add to the model with a p-value of &lt;0.05. 
     The final prediction model incorporated gene expression signature values from three gene expression signatures. The first gene expression signature added to the model was termed “ABC DLBCL high,” because it included genes that were more highly expressed in ABC than in GCB (Rosenwald 2002). The second gene expression signature added to the model was termed “lymph node,” because it reflected the response of non-tumor cells in the lymph node to the malignant lymphoma cells. The final gene expression signature added to the model was termed “MHC class II,” because it included all of the genes encoding the MHC class II alpha and beta chains. Table 2369 shows the genes that were averaged to form each of these signatures. 
     
       
         
           
               
               
               
               
               
             
               
                   
                 TABLE 2369 
               
               
                   
                   
               
               
                   
                   
                   
                   
                 Survival 
               
               
                   
                 Signature 
                 UNIQID 
                 Gene symbol 
                 p-value 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                 ABC DLBCL high 
                 1134271 
                 POU5F1 
                 3.09E−05 
               
               
                   
                 ABC DLBCL high 
                 1121564 
                 DRIL1 
                 4.06E−05 
               
               
                   
                 ABC DLBCL high 
                 1119889 
                 PDCD4 
                 7.28E−05 
               
               
                   
                 ABC DLBCL high 
                 1133300 
                 CTH 
                 1.23E−04 
               
               
                   
                 ABC DLBCL high 
                 1106030 
                 MGC: 50789 
                 1.70E−04 
               
               
                   
                 ABC DLBCL high 
                 1139301 
                 FLJ20150 
                 4.49E−04 
               
               
                   
                 ABC DLBCL high 
                 1122131 
                 CHST7 
                 5.18E−04 
               
               
                   
                 ABC DLBCL high 
                 1114824 
                 LIMD1 
                 5.20E−04 
               
               
                   
                 ABC DLBCL high 
                 1100161 
                 LOC142678 
                 6.24E−04 
               
               
                   
                 ABC DLBCL high 
                 1120129 
                 TLE1 
                 6.95E−04 
               
               
                   
                 Lymph node 
                 1097126 
                 TEM8 
                 5.14E−09 
               
               
                   
                 Lymph node 
                 1120880 
                 LTBP2 
                 9.80E−07 
               
               
                   
                 Lymph node 
                 1098898 
                 FLJ31066 
                 1.09E−06 
               
               
                   
                 Lymph node 
                 1123376 
                 RARRES2 
                 1.68E−06 
               
               
                   
                 Lymph node 
                 1128945 
                 SLC12A8 
                 2.90E−06 
               
               
                   
                 Lymph node 
                 1130994 
                 DPYSL3 
                 3.37E−06 
               
               
                   
                 Lymph node 
                 1124429 
                 SULF1 
                 3.53E−06 
               
               
                   
                 Lymph node 
                 1099358 
                 FLJ39971 
                 4.09E−06 
               
               
                   
                 Lymph node 
                 1130509 
                 SPARC 
                 6.23E−06 
               
               
                   
                 Lymph node 
                 1095985 
                 TMEPAI 
                 7.07E−06 
               
               
                   
                 Lymph node 
                 1123038 
                 ACTN1 
                 7.90E−06 
               
               
                   
                 Lymph node 
                 1133700 
                 CDH11 
                 8.20E−06 
               
               
                   
                 Lymph node 
                 1122101 
                 TFEC 
                 9.66E−06 
               
               
                   
                 Lymph node 
                 1124296 
                 SDC2 
                 9.99E−06 
               
               
                   
                 MHC Class II 
                 1123127 
                 HLA-DRA 
                 1.21E−06 
               
               
                   
                 MHC Class II 
                 1136777 
                 HLA-DQA1 
                 3.45E−06 
               
               
                   
                 MHC Class II 
                 1137771 
                 HLA-DRB1 
                 3.95E−06 
               
               
                   
                 MHC Class II 
                 1134281 
                 HLA-DRB4 
                 2.70E−05 
               
               
                   
                 MHC Class II 
                 1136573 
                 HLA-DPA1 
                 2.92E−05 
               
               
                   
                 MHC Class II 
                 1132710 
                 HLA-DRB3 
                 7.09E−05 
               
               
                   
                   
               
            
           
         
       
     
     Fitting the Cox proportional hazards model to the three gene expression signature values resulted in the following model:
 
Survival predictor score=[0.586*(ABC DLBCL high gene expression signature value)]−[0.468*(lymph node gene expression signature value)]−[0.336*(MHC Class II gene expression signature value)].
 
A higher survival predictor score was associated with worse outcome. According to a likelihood ratio test adjusted for the number of variables included, this model was significant in predicting survival at p=2.13×10 −13 . In order to visualize the predictive power of the model, the 205 samples used to create the model were ranked according to their survival predictor scores and divided into four quartiles. Kaplan-Meier plots of overall survival probability show clear differences in survival rate between these four quartiles ( FIG. 10 ). The five-year survival probabilities for each quartile are set forth in Table 2370.
 
     
       
         
           
               
               
               
             
               
                   
                 TABLE 2370 
               
               
                   
                   
               
               
                   
                 Quartile 
                 5-year survival 
               
               
                   
                   
               
             
            
               
                   
                 1 
                 83% 
               
               
                   
                 2 
                 59% 
               
               
                   
                 3 
                 33% 
               
               
                   
                 4 
                 17% 
               
               
                   
                   
               
            
           
         
       
     
     Example 7 
     Development of a Second DLBCL Survival Predictor Using Gene Expression Data from the Lymph Dx Microarray 
     A DLBCL survival model based on gene expression had been developed previously using proliferation, germinal center B-cell, lymph node, and MHC class II gene expression signatures and the expression of the single gene BMP-6 (Rosenwald 2002). BMP-6 expression was poorly measured on the Lymph Dx microarray, but genes associated with each of these four gene expression signatures exhibited associations with survival similar to those observed using Lymphochip microarrays. DLBCL samples were divided into two groups: a training set (100 samples) for developing the survival prediction model, and a validation set (100 samples) for evaluating the reproducibility of the model. Gene expressed in the training set samples were clustered, and lymph node, germinal center B-cell, MHC class II, and proliferation gene expression signatures were identified. Within each signature, expression of genes that were associated with survival (p&lt;0.01) was averaged to generate a gene expression signature value for each signature. Table 2371 lists the genes that were used to generate the gene expression signature value for each signature. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 2371 
               
               
                   
               
               
                 Signature 
                 UNIQID 
                 Unigene ID Build 167 
                 Gene symbol 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 Germinal center B-cell 
                 1099686 
                 117721 
                   
               
               
                 Germinal center B-cell 
                 1099711 
                 243596 
               
               
                 Germinal center B-cell 
                 1103390 
                 271752 
                 BPNT1 
               
               
                 Germinal center B-cell 
                 1106025 
                 49500 
                 KIAA0746 
               
               
                 Germinal center B-cell 
                 1128287 
                 300063 
                 ASB13 
               
               
                 Germinal center B-cell 
                 1132520 
                 283063 
                 LMO2 
               
               
                 Germinal center B-cell 
                 1138192 
                 126608 
                 NR3C1 
               
               
                 Germinal center B-cell 
                 1529318 
                 291954 
               
               
                 Germinal center B-cell 
                 1529344 
                 317970 
                 SERPINA11 
               
               
                 Germinal center B-cell 
                 1529352 
                 446195 
               
               
                 Germinal center B-cell 
                 1096570 
                 409813 
                 ANUBL1 
               
               
                 Germinal center B-cell 
                 1097897 
                 266175 
                 PAG 
               
               
                 Germinal center B-cell 
                 1097901 
                 266175 
                 PAG 
               
               
                 Germinal center B-cell 
                 1098611 
                 433611 
                 PDK1 
               
               
                 Germinal center B-cell 
                 1100581 
                 155024 
                 BCL6 
               
               
                 Germinal center B-cell 
                 1115034 
                 387222 
                 NEK6 
               
               
                 Germinal center B-cell 
                 1120090 
                 155024 
                 BCL6 
               
               
                 Germinal center B-cell 
                 1120946 
                 25209 
                 MAPK10 
               
               
                 Germinal center B-cell 
                 1121248 
                 54089 
                 BARD1 
               
               
                 Germinal center B-cell 
                 1123105 
                 434281 
                 PTK2 
               
               
                 Germinal center B-cell 
                 1125456 
                 300592 
                 MYBL1 
               
               
                 Germinal center B-cell 
                 1128694 
                 171466 
                 ELL3 
               
               
                 Germinal center B-cell 
                 1128787 
                 114611 
                 C7orf10 
               
               
                 Germinal center B-cell 
                 1132122 
                 307734 
                 MME 
               
               
                 Germinal center B-cell 
                 1136269 
                 101474 
                 MAST2 
               
               
                 Germinal center B-cell 
                 1136702 
                 155584 
                 KIAA0121 
               
               
                 Germinal center B-cell 
                 1139230 
                 29724 
                 PLEKHF2 
               
               
                 Germinal center B-cell 
                 1529292 
                 NA 
               
               
                 Germinal center B-cell 
                 1529295 
                 116441 
               
               
                 Lymph node 
                 1097126 
                 274520 
                 ANTXR1 
               
               
                 Lymph node 
                 1099028 
                 334838 
                 FNDC1 
               
               
                 Lymph node 
                 1099358 
                 93135 
               
               
                 Lymph node 
                 1101478 
                 146246 
                 MGC45780 
               
               
                 Lymph node 
                 1103497 
                 50115 
               
               
                 Lymph node 
                 1121029 
                 412999 
                 CSTA 
               
               
                 Lymph node 
                 1124429 
                 409602 
                 SULF1 
               
               
                 Lymph node 
                 1135068 
                 71719 
                 PDLIM3 
               
               
                 Lymph node 
                 1136051 
                 520937 
                 CSF2RA 
               
               
                 Lymph node 
                 1136172 
                 38084 
                 SULT1C1 
               
               
                 MHC class II 
                 1136777 
                 387679 
                 HLA-DQA1 
               
               
                 MHC class II 
                 1136877 
                 409934 
                 HLA-DQB1 
               
               
                 Proliferation 
                 1096903 
                 437460 
                 FLJ10385 
               
               
                 Proliferation 
                 1120583 
                 153768 
                 RNU3IP2 
               
               
                 Proliferation 
                 1123289 
                 5409 
                 POLR1C 
               
               
                 Proliferation 
                 1131808 
                 75447 
                 RALBP1 
               
               
                 Proliferation 
                 1133102 
                 360041 
                 FRDA 
               
               
                 Proliferation 
                 1136595 
                 404814 
                 VDAC1 
               
               
                   
               
            
           
         
       
     
     Table 2372 lists p-values for the association of each signature with survival in the training set, the validation set, and overall. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 2372 
               
               
                   
               
               
                 Signature 
                 Training set 
                 Validation set 
                 Overall 
               
               
                   
               
             
            
               
                 Lymph node 
                 4.0 × 10 −5   
                 2.3 × 10 −6   
                     6.8 × 10 −10   
               
               
                 Proliferation 
                 8.1 × 10 −5   
                 3.4 × 10 −3   
                 2.1 × 10 −6   
               
               
                 Germinal center B-cell 
                 6.2 × 10 −6   
                 2.1 × 10 −3   
                 5.0 × 10 −8   
               
               
                 MHC class II 
                 2.4 × 10 −2   
                 2.7 × 10 −3   
                 3.1 × 10 −4   
               
               
                   
               
            
           
         
       
     
     The four gene expression signatures were used to generate a survival predictor score using the following equation:
 
Survival predictor score=[−0.4337*(lymph node gene expression signature value)]+[0.09*(proliferation gene expression signature value)]−[0.4144*(germinal center B-cell gene expression signature value)]−[0.2006*(MHC class II gene expression signature value)].
 
A higher survival predictor score was associated with worse outcome. For the 200 DLBCL samples used to generate the model, the survival predictor score had a mean of 5.7 and a standard deviation of 0.78, with each unit increase in the predictor score corresponding to an approximately 2.7 fold increase in the relative risk of death. Data for all 200 samples is presented in Table 2373.
 
     
       
         
           
               
               
               
               
               
               
               
             
               
                 TABLE 2373 
               
               
                   
               
               
                   
                   
                   
                   
                 Germinal 
                   
                   
               
               
                   
                   
                 Lymph 
                   
                 center B- 
                 MHC 
               
               
                   
                   
                 node 
                 Proliferation 
                 cell 
                 class II 
                 Survival 
               
               
                   
                   
                 signature 
                 signature 
                 signature 
                 signature 
                 predictor 
               
               
                 Sample ID # 
                 Set 
                 value 
                 value 
                 value 
                 value 
                 score 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                 ABC_1000 
                 Validation 
                 6.50 
                 8.92 
                 7.60 
                 11.50 
                 −5.08 
               
               
                 ABC_1002 
                 Validation 
                 7.00 
                 8.58 
                 7.27 
                 12.54 
                 −5.50 
               
               
                 ABC_1023 
                 Validation 
                 7.43 
                 8.99 
                 6.80 
                 11.42 
                 −5.05 
               
               
                 ABC_1027 
                 Training 
                 5.68 
                 9.00 
                 6.87 
                 12.31 
                 −4.70 
               
               
                 ABC_1031 
                 Validation 
                 8.02 
                 9.00 
                 7.17 
                 11.68 
                 −5.53 
               
               
                 ABC_1034 
                 Validation 
                 6.06 
                 9.61 
                 6.72 
                 11.83 
                 −4.58 
               
               
                 ABC_1038 
                 Training 
                 6.83 
                 8.97 
                 7.17 
                 12.30 
                 −5.23 
               
               
                 ABC_1043 
                 Training 
                 6.96 
                 9.01 
                 6.77 
                 12.29 
                 −5.11 
               
               
                 ABC_1045 
                 Validation 
                 8.18 
                 8.21 
                 6.77 
                 12.07 
                 −5.66 
               
               
                 ABC_1055 
                 Validation 
                 5.58 
                 9.16 
                 7.30 
                 13.05 
                 −4.76 
               
               
                 ABC_1057 
                 Training 
                 7.33 
                 8.94 
                 7.74 
                 12.05 
                 −5.53 
               
               
                 ABC_1059 
                 Validation 
                 9.02 
                 8.46 
                 7.15 
                 11.35 
                 −6.08 
               
               
                 ABC_1061 
                 Training 
                 7.13 
                 9.18 
                 7.09 
                 12.28 
                 −5.21 
               
               
                 ABC_304 
                 Validation 
                 5.92 
                 8.80 
                 6.76 
                 12.76 
                 −4.84 
               
               
                 ABC_305 
                 Training 
                 5.92 
                 8.74 
                 7.50 
                 11.89 
                 −4.91 
               
               
                 ABC_309 
                 Validation 
                 8.86 
                 8.39 
                 7.62 
                 12.53 
                 −6.46 
               
               
                 ABC_413 
                 Validation 
                 6.45 
                 9.32 
                 6.55 
                 9.04 
                 −4.16 
               
               
                 ABC_428 
                 Training 
                 7.52 
                 9.19 
                 7.98 
                 10.25 
                 −5.51 
               
               
                 ABC_432 
                 Validation 
                 6.48 
                 9.33 
                 7.45 
                 9.56 
                 −4.56 
               
               
                 ABC_446 
                 Training 
                 7.91 
                 9.42 
                 7.41 
                 10.55 
                 −5.46 
               
               
                 ABC_462 
                 Validation 
                 6.41 
                 8.85 
                 6.67 
                 13.36 
                 −5.03 
               
               
                 ABC_477 
                 Validation 
                 6.26 
                 9.02 
                 6.69 
                 12.45 
                 −4.89 
               
               
                 ABC_481 
                 Training 
                 8.18 
                 8.30 
                 7.35 
                 11.98 
                 −5.91 
               
               
                 ABC_482 
                 Training 
                 8.59 
                 9.01 
                 7.66 
                 12.35 
                 −6.16 
               
               
                 ABC_538 
                 Validation 
                 8.06 
                 8.84 
                 7.17 
                 11.83 
                 −5.69 
               
               
                 ABC_541 
                 Training 
                 6.14 
                 8.52 
                 7.42 
                 10.59 
                 −4.71 
               
               
                 ABC_544 
                 Training 
                 6.91 
                 9.03 
                 6.82 
                 11.87 
                 −4.89 
               
               
                 ABC_547 
                 Validation 
                 5.80 
                 8.96 
                 7.14 
                 11.38 
                 −4.60 
               
               
                 ABC_577 
                 Validation 
                 7.84 
                 8.65 
                 8.16 
                 11.95 
                 −5.94 
               
               
                 ABC_616 
                 Validation 
                 6.03 
                 9.05 
                 7.36 
                 12.64 
                 −4.84 
               
               
                 ABC_626 
                 Validation 
                 7.48 
                 9.22 
                 7.25 
                 11.11 
                 −5.27 
               
               
                 ABC_633 
                 Training 
                 7.74 
                 8.35 
                 7.39 
                 12.45 
                 −5.80 
               
               
                 ABC_642 
                 Training 
                 5.71 
                 8.82 
                 6.41 
                 13.80 
                 −4.62 
               
               
                 ABC_644 
                 Validation 
                 6.64 
                 9.15 
                 7.05 
                 13.28 
                 −5.20 
               
               
                 ABC_645 
                 Training 
                 8.44 
                 8.81 
                 7.93 
                 13.39 
                 −6.43 
               
               
                 ABC_646 
                 Validation 
                 5.94 
                 9.11 
                 6.71 
                 11.60 
                 −4.63 
               
               
                 ABC_652 
                 Validation 
                 5.87 
                 8.85 
                 6.88 
                 12.73 
                 −4.77 
               
               
                 ABC_660 
                 Training 
                 5.19 
                 9.34 
                 6.64 
                 10.17 
                 −3.86 
               
               
                 ABC_663 
                 Training 
                 5.69 
                 9.02 
                 7.33 
                 12.82 
                 −4.91 
               
               
                 ABC_668 
                 Validation 
                 7.12 
                 9.28 
                 7.03 
                 10.57 
                 −4.91 
               
               
                 ABC_676 
                 Training 
                 4.95 
                 8.90 
                 7.09 
                 13.32 
                 −4.61 
               
               
                 ABC_678 
                 Training 
                 5.84 
                 9.11 
                 7.34 
                 11.26 
                 −4.41 
               
               
                 ABC_687 
                 Validation 
                 5.15 
                 9.89 
                 6.56 
                 10.46 
                 −3.76 
               
               
                 ABC_689 
                 Training 
                 6.49 
                 8.86 
                 7.10 
                 12.56 
                 −4.88 
               
               
                 ABC_692 
                 Validation 
                 7.32 
                 8.96 
                 7.25 
                 11.57 
                 −5.32 
               
               
                 ABC_694 
                 Validation 
                 8.28 
                 9.21 
                 8.01 
                 12.41 
                 −6.23 
               
               
                 ABC_700 
                 Training 
                 7.29 
                 8.97 
                 7.55 
                 12.10 
                 −5.48 
               
               
                 ABC_702 
                 Validation 
                 7.60 
                 8.66 
                 6.86 
                 12.55 
                 −5.45 
               
               
                 ABC_704 
                 Training 
                 7.07 
                 8.92 
                 7.03 
                 12.83 
                 −5.35 
               
               
                 ABC_709 
                 Validation 
                 5.92 
                 8.58 
                 6.37 
                 13.40 
                 −4.66 
               
               
                 ABC_712 
                 Validation 
                 5.79 
                 9.12 
                 6.34 
                 12.02 
                 −4.23 
               
               
                 ABC_714 
                 Training 
                 7.49 
                 8.88 
                 7.49 
                 11.97 
                 −5.54 
               
               
                 ABC_717 
                 Training 
                 7.17 
                 9.45 
                 7.01 
                 11.34 
                 −5.05 
               
               
                 ABC_725 
                 Training 
                 6.71 
                 9.01 
                 6.52 
                 12.76 
                 −4.86 
               
               
                 ABC_726 
                 Validation 
                 6.91 
                 8.72 
                 6.71 
                 11.91 
                 −4.90 
               
               
                 ABC_730 
                 Validation 
                 6.28 
                 9.22 
                 7.28 
                 12.14 
                 −4.88 
               
               
                 ABC_753 
                 Training 
                 6.84 
                 9.64 
                 7.05 
                 13.00 
                 −5.22 
               
               
                 ABC_756 
                 Training 
                 7.67 
                 8.45 
                 7.59 
                 12.48 
                 −5.85 
               
               
                 ABC_771 
                 Training 
                 6.98 
                 8.76 
                 6.91 
                 12.20 
                 −5.18 
               
               
                 ABC_779 
                 Training 
                 6.73 
                 9.32 
                 6.78 
                 9.82 
                 −4.44 
               
               
                 ABC_800 
                 Validation 
                 8.75 
                 8.31 
                 7.45 
                 11.91 
                 −6.04 
               
               
                 ABC_807 
                 Training 
                 5.50 
                 9.53 
                 6.92 
                 7.56 
                 −3.79 
               
               
                 ABC_809 
                 Training 
                 7.40 
                 8.70 
                 7.68 
                 10.83 
                 −5.50 
               
               
                 ABC_816 
                 Training 
                 5.20 
                 9.91 
                 7.65 
                 10.64 
                 −4.14 
               
               
                 ABC_820 
                 Training 
                 6.71 
                 8.94 
                 6.55 
                 11.98 
                 −4.85 
               
               
                 ABC_823 
                 Validation 
                 5.58 
                 9.26 
                 6.44 
                 10.09 
                 −3.97 
               
               
                 ABC_835 
                 Validation 
                 6.95 
                 8.68 
                 8.04 
                 12.31 
                 −5.59 
               
               
                 ABC_839 
                 Training 
                 6.63 
                 9.17 
                 7.23 
                 11.89 
                 −5.04 
               
               
                 ABC_841 
                 Validation 
                 6.35 
                 9.51 
                 7.52 
                 13.19 
                 −5.28 
               
               
                 ABC_858 
                 Training 
                 7.63 
                 8.51 
                 7.12 
                 11.74 
                 −5.42 
               
               
                 ABC_872 
                 Training 
                 6.78 
                 8.73 
                 7.41 
                 12.47 
                 −5.44 
               
               
                 ABC_875 
                 Training 
                 7.59 
                 8.81 
                 7.20 
                 11.26 
                 −5.25 
               
               
                 ABC_912 
                 Validation 
                 7.01 
                 8.55 
                 7.45 
                 12.79 
                 −5.64 
               
               
                 ABC_996 
                 Validation 
                 5.00 
                 9.53 
                 6.70 
                 10.02 
                 −3.94 
               
               
                 GCB_1005 
                 Validation 
                 8.28 
                 8.67 
                 9.11 
                 13.27 
                 −6.98 
               
               
                 GCB_1008 
                 Training 
                 8.17 
                 8.59 
                 9.83 
                 12.83 
                 −7.06 
               
               
                 GCB_1009 
                 Training 
                 6.63 
                 9.02 
                 10.07 
                 12.28 
                 −6.19 
               
               
                 GCB_1021 
                 Validation 
                 6.44 
                 8.83 
                 9.34 
                 13.20 
                 −6.15 
               
               
                 GCB_1025 
                 Validation 
                 7.87 
                 8.48 
                 9.27 
                 12.37 
                 −6.57 
               
               
                 GCB_1026 
                 Training 
                 7.71 
                 8.30 
                 9.81 
                 13.52 
                 −6.85 
               
               
                 GCB_1037 
                 Training 
                 4.95 
                 8.83 
                 9.35 
                 12.57 
                 −5.22 
               
               
                 GCB_1039 
                 Training 
                 7.63 
                 8.65 
                 9.01 
                 13.28 
                 −6.47 
               
               
                 GCB_1049 
                 Validation 
                 8.54 
                 8.61 
                 8.12 
                 12.60 
                 −6.41 
               
               
                 GCB_1051 
                 Validation 
                 6.26 
                 9.09 
                 9.48 
                 12.76 
                 −5.97 
               
               
                 GCB_1058 
                 Validation 
                 7.12 
                 8.89 
                 8.34 
                 12.80 
                 −5.85 
               
               
                 GCB_1060 
                 Validation 
                 8.27 
                 8.84 
                 8.94 
                 12.96 
                 −6.75 
               
               
                 GCB_412 
                 Training 
                 7.22 
                 8.33 
                 8.50 
                 13.09 
                 −6.09 
               
               
                 GCB_415 
                 Training 
                 9.01 
                 8.62 
                 8.38 
                 11.99 
                 −6.47 
               
               
                 GCB_421 
                 Training 
                 7.59 
                 7.89 
                 7.49 
                 12.20 
                 −5.80 
               
               
                 GCB_424 
                 Training 
                 9.29 
                 8.42 
                 8.51 
                 12.44 
                 −6.79 
               
               
                 GCB_433 
                 Training 
                 8.45 
                 8.34 
                 8.02 
                 12.64 
                 −6.54 
               
               
                 GCB_434 
                 Training 
                 8.46 
                 8.55 
                 9.17 
                 12.54 
                 −6.98 
               
               
                 GCB_438 
                 Validation 
                 8.14 
                 8.71 
                 9.13 
                 12.51 
                 −6.67 
               
               
                 GCB_459 
                 Validation 
                 8.98 
                 8.39 
                 8.42 
                 11.37 
                 −6.49 
               
               
                 GCB_470 
                 Validation 
                 7.72 
                 8.57 
                 8.67 
                 12.23 
                 −6.12 
               
               
                 GCB_479 
                 Validation 
                 6.86 
                 8.25 
                 7.13 
                 13.07 
                 −5.35 
               
               
                 GCB_492 
                 Training 
                 8.01 
                 8.61 
                 9.51 
                 12.34 
                 −6.63 
               
               
                 GCB_517 
                 Validation 
                 8.57 
                 8.73 
                 7.99 
                 12.76 
                 −6.48 
               
               
                 GCB_523 
                 Training 
                 5.96 
                 8.56 
                 8.74 
                 12.77 
                 −5.72 
               
               
                 GCB_524 
                 Training 
                 8.51 
                 8.09 
                 8.76 
                 12.51 
                 −6.57 
               
               
                 GCB_529 
                 Training 
                 5.12 
                 9.17 
                 8.88 
                 10.77 
                 −4.86 
               
               
                 GCB_533 
                 Training 
                 8.88 
                 8.81 
                 8.36 
                 12.44 
                 −6.60 
               
               
                 GCB_537 
                 Validation 
                 7.42 
                 8.19 
                 9.73 
                 13.29 
                 −6.68 
               
               
                 GCB_543 
                 Validation 
                 8.49 
                 8.02 
                 8.66 
                 12.06 
                 −6.45 
               
               
                 GCB_545 
                 Training 
                 8.65 
                 8.28 
                 6.90 
                 12.90 
                 −6.13 
               
               
                 GCB_549 
                 Validation 
                 6.87 
                 8.24 
                 8.65 
                 12.15 
                 −6.00 
               
               
                 GCB_550 
                 Validation 
                 8.98 
                 8.29 
                 8.76 
                 12.24 
                 −6.94 
               
               
                 GCB_553 
                 Validation 
                 8.51 
                 8.64 
                 8.62 
                 12.63 
                 −6.69 
               
               
                 GCB_565 
                 Validation 
                 7.97 
                 8.79 
                 9.79 
                 13.42 
                 −6.98 
               
               
                 GCB_572 
                 Training 
                 7.61 
                 8.60 
                 9.39 
                 12.58 
                 −6.42 
               
               
                 GCB_617 
                 Validation 
                 8.31 
                 7.89 
                 7.54 
                 13.17 
                 −6.12 
               
               
                 GCB_618 
                 Training 
                 5.66 
                 8.97 
                 9.20 
                 13.32 
                 −5.54 
               
               
                 GCB_619 
                 Validation 
                 7.83 
                 8.65 
                 9.34 
                 12.12 
                 −6.36 
               
               
                 GCB_623 
                 Training 
                 7.16 
                 8.88 
                 9.26 
                 12.35 
                 −6.21 
               
               
                 GCB_627 
                 Validation 
                 8.13 
                 8.83 
                 8.62 
                 11.85 
                 −6.31 
               
               
                 GCB_654 
                 Training 
                 6.30 
                 9.60 
                 8.45 
                 10.00 
                 −4.88 
               
               
                 GCB_661 
                 Validation 
                 8.46 
                 8.51 
                 8.18 
                 12.66 
                 −6.33 
               
               
                 GCB_669 
                 Training 
                 7.88 
                 8.65 
                 8.59 
                 12.32 
                 −6.19 
               
               
                 GCB_672 
                 Training 
                 8.29 
                 8.61 
                 8.14 
                 12.41 
                 −6.21 
               
               
                 GCB_674 
                 Validation 
                 8.36 
                 8.62 
                 7.76 
                 12.33 
                 −6.14 
               
               
                 GCB_675 
                 Validation 
                 6.01 
                 9.52 
                 8.90 
                 10.12 
                 −5.09 
               
               
                 GCB_681 
                 Training 
                 9.25 
                 8.72 
                 8.72 
                 12.59 
                 −6.89 
               
               
                 GCB_688 
                 Validation 
                 6.97 
                 9.01 
                 9.90 
                 9.94 
                 −5.99 
               
               
                 GCB_695 
                 Validation 
                 8.80 
                 8.73 
                 9.23 
                 12.45 
                 −6.84 
               
               
                 GCB_698 
                 Validation 
                 9.27 
                 8.35 
                 8.85 
                 11.99 
                 −6.96 
               
               
                 GCB_701 
                 Training 
                 7.77 
                 7.93 
                 8.68 
                 13.10 
                 −6.33 
               
               
                 GCB_710 
                 Validation 
                 6.12 
                 8.78 
                 7.65 
                 13.19 
                 −5.24 
               
               
                 GCB_711 
                 Training 
                 7.57 
                 8.80 
                 8.43 
                 11.44 
                 −5.84 
               
               
                 GCB_722 
                 Training 
                 7.78 
                 8.31 
                 8.93 
                 12.61 
                 −6.51 
               
               
                 GCB_724 
                 Training 
                 7.88 
                 9.08 
                 8.74 
                 11.53 
                 −6.21 
               
               
                 GCB_731 
                 Validation 
                 7.72 
                 8.92 
                 9.08 
                 12.20 
                 −6.46 
               
               
                 GCB_742 
                 Validation 
                 8.33 
                 8.55 
                 8.58 
                 12.95 
                 −6.70 
               
               
                 GCB_744 
                 Training 
                 8.02 
                 8.64 
                 9.36 
                 11.85 
                 −6.52 
               
               
                 GCB_745 
                 Training 
                 8.47 
                 8.34 
                 8.93 
                 11.95 
                 −6.67 
               
               
                 GCB_747 
                 Validation 
                 7.64 
                 8.48 
                 8.32 
                 13.06 
                 −6.27 
               
               
                 GCB_749 
                 Training 
                 7.57 
                 8.61 
                 9.40 
                 12.55 
                 −6.56 
               
               
                 GCB_758 
                 Validation 
                 5.66 
                 8.77 
                 7.89 
                 12.51 
                 −4.63 
               
               
                 GCB_772 
                 Validation 
                 8.52 
                 7.81 
                 7.95 
                 12.25 
                 −6.34 
               
               
                 GCB_777 
                 Validation 
                 7.52 
                 8.65 
                 8.57 
                 11.69 
                 −6.10 
               
               
                 GCB_792 
                 Training 
                 8.14 
                 8.64 
                 9.21 
                 12.08 
                 −6.65 
               
               
                 GCB_795 
                 Validation 
                 9.19 
                 8.17 
                 8.81 
                 11.60 
                 −6.92 
               
               
                 GCB_797 
                 Validation 
                 7.50 
                 8.62 
                 8.08 
                 12.84 
                 −6.09 
               
               
                 GCB_803 
                 Validation 
                 6.19 
                 8.65 
                 9.49 
                 13.18 
                 −6.11 
               
               
                 GCB_810 
                 Training 
                 8.46 
                 8.32 
                 8.10 
                 13.13 
                 −6.50 
               
               
                 GCB_817 
                 Training 
                 6.93 
                 8.51 
                 9.49 
                 11.09 
                 −6.04 
               
               
                 GCB_818 
                 Training 
                 7.18 
                 8.96 
                 8.08 
                 12.23 
                 −5.76 
               
               
                 GCB_819 
                 Validation 
                 7.16 
                 8.97 
                 8.06 
                 13.22 
                 −5.79 
               
               
                 GCB_821 
                 Validation 
                 8.13 
                 8.59 
                 8.90 
                 12.41 
                 −6.61 
               
               
                 GCB_832 
                 Training 
                 7.83 
                 8.35 
                 8.71 
                 12.47 
                 −6.37 
               
               
                 GCB_836 
                 Validation 
                 7.84 
                 8.99 
                 8.50 
                 11.46 
                 −5.85 
               
               
                 GCB_840 
                 Training 
                 8.24 
                 7.75 
                 7.40 
                 11.74 
                 −5.77 
               
               
                 GCB_847 
                 Training 
                 7.82 
                 8.17 
                 8.97 
                 12.55 
                 −6.51 
               
               
                 GCB_860 
                 Training 
                 7.12 
                 8.39 
                 9.34 
                 11.54 
                 −6.10 
               
               
                 GCB_871 
                 Training 
                 5.59 
                 9.60 
                 7.28 
                 11.16 
                 −4.23 
               
               
                 GCB_874 
                 Training 
                 8.53 
                 9.14 
                 8.95 
                 11.65 
                 −6.47 
               
               
                 GCB_995 
                 Validation 
                 6.98 
                 8.68 
                 8.54 
                 12.22 
                 −5.76 
               
               
                 PMBL_1006 
                 Validation 
                 7.34 
                 8.51 
                 7.66 
                 10.94 
                 −5.33 
               
               
                 PMBL_1024 
                 Validation 
                 7.62 
                 8.48 
                 8.56 
                 10.89 
                 −5.96 
               
               
                 PMBL_1048 
                 Validation 
                 8.68 
                 8.16 
                 7.23 
                 12.18 
                 −6.08 
               
               
                 PMBL_1053 
                 Training 
                 7.02 
                 8.28 
                 8.24 
                 11.12 
                 −5.31 
               
               
                 PMBL_484 
                 Training 
                 7.15 
                 8.45 
                 7.01 
                 13.62 
                 −5.41 
               
               
                 PMBL_546 
                 Validation 
                 8.19 
                 7.88 
                 7.66 
                 11.73 
                 −6.06 
               
               
                 PMBL_570 
                 Training 
                 9.34 
                 8.21 
                 8.48 
                 12.70 
                 −6.86 
               
               
                 PMBL_621 
                 Training 
                 8.08 
                 8.60 
                 9.14 
                 12.96 
                 −6.72 
               
               
                 PMBL_638 
                 Training 
                 7.56 
                 8.26 
                 8.00 
                 11.37 
                 −5.75 
               
               
                 PMBL_691 
                 Validation 
                 6.48 
                 8.92 
                 8.40 
                 10.17 
                 −5.04 
               
               
                 PMBL_791 
                 Validation 
                 7.72 
                 8.65 
                 8.94 
                 11.56 
                 −6.16 
               
               
                 PMBL_824 
                 Validation 
                 8.06 
                 8.01 
                 7.76 
                 13.28 
                 −6.11 
               
               
                 PMBL_994 
                 Training 
                 9.15 
                 8.36 
                 7.46 
                 12.43 
                 −6.29 
               
               
                 PMBL_998 
                 Training 
                 6.70 
                 8.35 
                 9.24 
                 13.19 
                 −6.20 
               
               
                 UC_DLBCL_1001 
                 Validation 
                 6.74 
                 8.43 
                 7.10 
                 12.76 
                 −5.31 
               
               
                 UC_DLBCL_1004 
                 Validation 
                 7.54 
                 8.75 
                 8.01 
                 13.09 
                 −6.10 
               
               
                 UC_DLBCL_1007 
                 Training 
                 9.97 
                 8.44 
                 7.64 
                 12.97 
                 −6.85 
               
               
                 UC_DLBCL_1018 
                 Training 
                 6.42 
                 8.38 
                 6.97 
                 12.71 
                 −5.03 
               
               
                 UC_DLBCL_1041 
                 Validation 
                 5.76 
                 8.69 
                 6.78 
                 13.38 
                 −4.71 
               
               
                 UC_DLBCL_1054 
                 Training 
                 8.92 
                 8.65 
                 8.51 
                 11.48 
                 −6.59 
               
               
                 UC_DLBCL_306 
                 Validation 
                 7.85 
                 8.90 
                 8.31 
                 12.36 
                 −6.23 
               
               
                 UC_DLBCL_310 
                 Training 
                 8.14 
                 8.80 
                 7.63 
                 12.27 
                 −6.03 
               
               
                 UC_DLBCL_449 
                 Validation 
                 9.03 
                 8.48 
                 7.07 
                 12.17 
                 −6.01 
               
               
                 UC_DLBCL_458 
                 Training 
                 5.92 
                 8.53 
                 8.28 
                 9.60 
                 −4.96 
               
               
                 UC_DLBCL_460 
                 Validation 
                 7.92 
                 9.08 
                 8.30 
                 12.29 
                 −6.13 
               
               
                 UC_DLBCL_491 
                 Training 
                 7.65 
                 8.33 
                 7.35 
                 12.39 
                 −5.53 
               
               
                 UC_DLBCL_528 
                 Validation 
                 6.99 
                 8.56 
                 7.36 
                 11.63 
                 −5.35 
               
               
                 UC_DLBCL_615 
                 Validation 
                 7.11 
                 8.32 
                 8.77 
                 12.80 
                 −6.10 
               
               
                 UC_DLBCL_625 
                 Training 
                 8.93 
                 7.78 
                 7.85 
                 12.62 
                 −6.46 
               
               
                 UC_DLBCL_664 
                 Training 
                 7.62 
                 8.15 
                 8.17 
                 12.72 
                 −6.04 
               
               
                 UC_DLBCL_671 
                 Training 
                 8.09 
                 8.48 
                 7.61 
                 11.53 
                 −5.78 
               
               
                 UC_DLBCL_682 
                 Training 
                 7.38 
                 8.35 
                 7.14 
                 12.33 
                 −5.43 
               
               
                 UC_DLBCL_683 
                 Training 
                 7.91 
                 8.36 
                 7.78 
                 12.57 
                 −6.02 
               
               
                 UC_DLBCL_684 
                 Validation 
                 8.06 
                 8.63 
                 8.29 
                 12.76 
                 −6.29 
               
               
                 UC_DLBCL_748 
                 Validation 
                 5.38 
                 8.57 
                 7.45 
                 9.55 
                 −4.23 
               
               
                 UC_DLBCL_751 
                 Training 
                 6.33 
                 8.65 
                 8.88 
                 13.14 
                 −5.74 
               
               
                 UC_DLBCL_808 
                 Training 
                 7.42 
                 9.01 
                 7.44 
                 13.09 
                 −5.63 
               
               
                 UC_DLBCL_831 
                 Validation 
                 8.33 
                 8.30 
                 7.46 
                 11.58 
                 −5.84 
               
               
                 UC_DLBCL_834 
                 Training 
                 6.98 
                 9.09 
                 8.61 
                 11.77 
                 −5.66 
               
               
                 UC_DLBCL_838 
                 Validation 
                 7.25 
                 8.40 
                 7.23 
                 12.56 
                 −5.36 
               
               
                 UC_DLBCL_851 
                 Validation 
                 6.28 
                 9.05 
                 6.78 
                 8.19 
                 −4.10 
               
               
                 UC_DLBCL_854 
                 Validation 
                 7.36 
                 8.50 
                 7.39 
                 12.59 
                 −5.53 
               
               
                 UC_DLBCL_855 
                 Training 
                 8.31 
                 7.94 
                 7.49 
                 12.08 
                 −6.07 
               
               
                 UC_DLBCL_856 
                 Validation 
                 5.65 
                 9.01 
                 8.52 
                 9.32 
                 −4.68 
               
               
                   
               
            
           
         
       
     
     In order to visualize the predictive power of the model, the 200 samples were ranked according to their survival predictor scores and divided into four quartiles. Kaplan-Meier plots of overall survival probability show clear differences in survival rate between these four quartiles ( FIG. 11 ). 
     Example 8 
     Development of a Third DLBCL Survival Predictor Using Gene Expression Data from the Lymph Dx Microarray 
     The number of genes used to generate the DLBCL survival predictor in Example 7 were reduced in order to create a survival predictor compatible with RT-PCR. The list of genes from the lymph node and germinal center B-cell gene expression signatures was narrowed to those three genes from each signature that were most closely correlated with the lymph node and germinal center B-cell gene expression signature values, respectively. The genes from the proliferation gene expression signature did not add significantly to the reduced gene survival prediction model, so they were removed entirely. The expression of the genes within each signature was averaged on the log 2  scale to generate a gene expression signature value for each signature. Table 2374 lists the genes that were used to generate these gene expression signature values. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 2374 
               
               
                   
               
               
                   
                   
                 Unigene ID Build 
                   
               
               
                 Signature 
                 UNIQID 
                 167 
                 Gene symbol 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 Germinal center B-cell 
                 1099686 
                 117721 
                   
               
               
                 Germinal center B-cell 
                 1529318 
                 291954 
               
               
                 Germinal center B-cell 
                 1529344 
                 317970 
                 SERPINA11 
               
               
                 Lymph node 
                 1097126 
                 274520 
                 ANTXR1 
               
               
                 Lymph node 
                 1099358 
                 93135 
               
               
                 Lymph node 
                 1121029 
                 412999 
                 CSTA 
               
               
                 MHC class II 
                 1136777 
                 387679 
                 HLA-DQA1 
               
               
                 MHC class II 
                 1136877 
                 409934 
                 HLA-DQB1 
               
               
                   
               
            
           
         
       
     
     Table 2375 lists p-values for the association of each signature with survival in the training set, the validation set, and overall. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 2375 
               
               
                   
               
               
                 Signature 
                 Training set 
                 Validation set 
                 Overall 
               
               
                   
               
             
            
               
                 Lymph node 
                 6.1 × 10 −6   
                 0.0021 
                     2.1 × 10 −17   
               
               
                 Germinal center B-cell 
                 3.5 × 10 −4   
                 0.0099 
                 2.7 × 10 −5   
               
               
                 MHC class II 
                 0.024 
                 0.0026 
                 0.00031 
               
               
                   
               
            
           
         
       
     
     The three gene expression signatures were used to generate a survival predictor score using the following equation:
 
Survival predictor score=[−0.32*(lymph node gene expression signature value)]−[0.176*(germinal center B-cell gene expression signature value)]−[0.206*(MHC class II gene expression signature value)].
 
A higher survival predictor score was associated with worse outcome. For the 200 DLBCL samples used to generate the model, the survival predictor score had a mean of 6.54 and a standard deviation of 0.69, with each unit increase in the predictor score corresponding to an approximately 2.7 fold increase in the relative risk of death. Data for all 200 samples is presented in Table 2376.
 
     
       
         
           
               
               
               
               
               
               
             
               
                 TABLE 2376 
               
               
                   
               
               
                   
                   
                   
                 Germinal 
                 MHC class 
                   
               
               
                   
                   
                 Lymph node 
                 center B-cell 
                 II 
                 Survival 
               
               
                   
                   
                 signature 
                 signature 
                 signature 
                 predictor 
               
               
                 Sample ID # 
                 Set 
                 value 
                 value 
                 value 
                 score 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 ABC_1000 
                 Validation 
                 8.08 
                 5.68 
                 11.50 
                 −5.96 
               
               
                 ABC_1002 
                 Validation 
                 8.32 
                 6.06 
                 12.54 
                 −6.31 
               
               
                 ABC_1023 
                 Validation 
                 9.36 
                 4.74 
                 11.42 
                 −6.18 
               
               
                 ABC_1027 
                 Training 
                 7.41 
                 4.90 
                 12.31 
                 −5.77 
               
               
                 ABC_1031 
                 Validation 
                 9.40 
                 5.23 
                 11.68 
                 −6.33 
               
               
                 ABC_1034 
                 Validation 
                 7.47 
                 4.92 
                 11.83 
                 −5.69 
               
               
                 ABC_1038 
                 Training 
                 7.89 
                 5.84 
                 12.30 
                 −6.09 
               
               
                 ABC_1043 
                 Training 
                 7.84 
                 4.66 
                 12.29 
                 −5.86 
               
               
                 ABC_1045 
                 Validation 
                 9.31 
                 4.66 
                 12.07 
                 −6.29 
               
               
                 ABC_1055 
                 Validation 
                 6.46 
                 6.38 
                 13.05 
                 −5.88 
               
               
                 ABC_1057 
                 Training 
                 9.13 
                 7.93 
                 12.05 
                 −6.80 
               
               
                 ABC_1059 
                 Validation 
                 10.93 
                 4.82 
                 11.35 
                 −6.68 
               
               
                 ABC_1061 
                 Training 
                 8.18 
                 5.04 
                 12.28 
                 −6.04 
               
               
                 ABC_304 
                 Validation 
                 7.31 
                 6.47 
                 12.76 
                 −6.10 
               
               
                 ABC_305 
                 Training 
                 7.02 
                 6.60 
                 11.89 
                 −5.86 
               
               
                 ABC_309 
                 Validation 
                 10.47 
                 7.00 
                 12.53 
                 −7.16 
               
               
                 ABC_413 
                 Validation 
                 7.99 
                 4.80 
                 9.04 
                 −5.26 
               
               
                 ABC_428 
                 Training 
                 9.43 
                 7.59 
                 10.25 
                 −6.47 
               
               
                 ABC_432 
                 Validation 
                 7.29 
                 8.16 
                 9.56 
                 −5.74 
               
               
                 ABC_446 
                 Training 
                 9.49 
                 5.46 
                 10.55 
                 −6.17 
               
               
                 ABC_462 
                 Validation 
                 7.72 
                 4.97 
                 13.36 
                 −6.10 
               
               
                 ABC_477 
                 Validation 
                 7.16 
                 3.69 
                 12.45 
                 −5.51 
               
               
                 ABC_481 
                 Training 
                 9.75 
                 6.89 
                 11.98 
                 −6.80 
               
               
                 ABC_482 
                 Training 
                 10.51 
                 7.64 
                 12.35 
                 −7.25 
               
               
                 ABC_538 
                 Validation 
                 8.79 
                 5.00 
                 11.83 
                 −6.13 
               
               
                 ABC_541 
                 Training 
                 7.70 
                 5.80 
                 10.59 
                 −5.67 
               
               
                 ABC_544 
                 Training 
                 8.90 
                 3.98 
                 11.87 
                 −5.99 
               
               
                 ABC_547 
                 Validation 
                 7.05 
                 5.18 
                 11.38 
                 −5.51 
               
               
                 ABC_577 
                 Validation 
                 9.93 
                 8.05 
                 11.95 
                 −7.06 
               
               
                 ABC_616 
                 Validation 
                 7.34 
                 4.54 
                 12.64 
                 −5.75 
               
               
                 ABC_626 
                 Validation 
                 8.78 
                 6.77 
                 11.11 
                 −6.29 
               
               
                 ABC_633 
                 Training 
                 9.63 
                 5.02 
                 12.45 
                 −6.53 
               
               
                 ABC_642 
                 Training 
                 7.31 
                 4.95 
                 13.80 
                 −6.05 
               
               
                 ABC_644 
                 Validation 
                 7.72 
                 5.35 
                 13.28 
                 −6.15 
               
               
                 ABC_645 
                 Training 
                 9.77 
                 6.21 
                 13.39 
                 −6.98 
               
               
                 ABC_646 
                 Validation 
                 7.39 
                 3.75 
                 11.60 
                 −5.41 
               
               
                 ABC_652 
                 Validation 
                 7.51 
                 4.53 
                 12.73 
                 −5.82 
               
               
                 ABC_660 
                 Training 
                 5.85 
                 3.55 
                 10.17 
                 −4.59 
               
               
                 ABC_663 
                 Training 
                 7.04 
                 5.06 
                 12.82 
                 −5.78 
               
               
                 ABC_668 
                 Validation 
                 8.00 
                 5.65 
                 10.57 
                 −5.73 
               
               
                 ABC_676 
                 Training 
                 6.53 
                 4.29 
                 13.32 
                 −5.59 
               
               
                 ABC_678 
                 Training 
                 6.87 
                 7.48 
                 11.26 
                 −5.83 
               
               
                 ABC_687 
                 Validation 
                 6.39 
                 3.78 
                 10.46 
                 −4.87 
               
               
                 ABC_689 
                 Training 
                 8.29 
                 5.07 
                 12.56 
                 −6.13 
               
               
                 ABC_692 
                 Validation 
                 8.10 
                 5.26 
                 11.57 
                 −5.90 
               
               
                 ABC_694 
                 Validation 
                 9.67 
                 8.15 
                 12.41 
                 −7.09 
               
               
                 ABC_700 
                 Training 
                 8.37 
                 6.75 
                 12.10 
                 −6.36 
               
               
                 ABC_702 
                 Validation 
                 8.44 
                 4.59 
                 12.55 
                 −6.09 
               
               
                 ABC_704 
                 Training 
                 8.51 
                 4.34 
                 12.83 
                 −6.13 
               
               
                 ABC_709 
                 Validation 
                 7.47 
                 4.54 
                 13.40 
                 −5.95 
               
               
                 ABC_712 
                 Validation 
                 7.12 
                 3.99 
                 12.02 
                 −5.46 
               
               
                 ABC_714 
                 Training 
                 9.57 
                 7.03 
                 11.97 
                 −6.77 
               
               
                 ABC_717 
                 Training 
                 8.33 
                 5.54 
                 11.34 
                 −5.98 
               
               
                 ABC_725 
                 Training 
                 8.04 
                 4.40 
                 12.76 
                 −5.97 
               
               
                 ABC_726 
                 Validation 
                 7.79 
                 4.18 
                 11.91 
                 −5.68 
               
               
                 ABC_730 
                 Validation 
                 8.13 
                 7.36 
                 12.14 
                 −6.40 
               
               
                 ABC_753 
                 Training 
                 9.24 
                 6.60 
                 13.00 
                 −6.80 
               
               
                 ABC_756 
                 Training 
                 9.51 
                 5.21 
                 12.48 
                 −6.53 
               
               
                 ABC_771 
                 Training 
                 8.08 
                 4.74 
                 12.20 
                 −5.93 
               
               
                 ABC_779 
                 Training 
                 8.11 
                 4.09 
                 9.82 
                 −5.34 
               
               
                 ABC_800 
                 Validation 
                 10.34 
                 4.83 
                 11.91 
                 −6.61 
               
               
                 ABC_807 
                 Training 
                 6.58 
                 4.44 
                 7.56 
                 −4.44 
               
               
                 ABC_809 
                 Training 
                 9.29 
                 5.72 
                 10.83 
                 −6.21 
               
               
                 ABC_816 
                 Training 
                 6.36 
                 6.36 
                 10.64 
                 −5.35 
               
               
                 ABC_820 
                 Training 
                 8.10 
                 4.79 
                 11.98 
                 −5.90 
               
               
                 ABC_823 
                 Validation 
                 6.63 
                 4.85 
                 10.09 
                 −5.05 
               
               
                 ABC_835 
                 Validation 
                 9.17 
                 7.78 
                 12.31 
                 −6.84 
               
               
                 ABC_839 
                 Training 
                 8.06 
                 4.97 
                 11.89 
                 −5.90 
               
               
                 ABC_841 
                 Validation 
                 8.05 
                 6.24 
                 13.19 
                 −6.39 
               
               
                 ABC_858 
                 Training 
                 9.02 
                 4.86 
                 11.74 
                 −6.16 
               
               
                 ABC_872 
                 Training 
                 8.67 
                 5.85 
                 12.47 
                 −6.37 
               
               
                 ABC_875 
                 Training 
                 9.60 
                 5.59 
                 11.26 
                 −6.37 
               
               
                 ABC_912 
                 Validation 
                 7.99 
                 7.74 
                 12.79 
                 −6.56 
               
               
                 ABC_996 
                 Validation 
                 6.89 
                 6.23 
                 10.02 
                 −5.36 
               
               
                 GCB_1005 
                 Validation 
                 9.02 
                 9.56 
                 13.27 
                 −7.30 
               
               
                 GCB_1008 
                 Training 
                 9.27 
                 10.49 
                 12.83 
                 −7.46 
               
               
                 GCB_1009 
                 Training 
                 7.80 
                 10.09 
                 12.28 
                 −6.80 
               
               
                 GCB_1021 
                 Validation 
                 8.73 
                 9.20 
                 13.20 
                 −7.13 
               
               
                 GCB_1025 
                 Validation 
                 9.94 
                 9.97 
                 12.37 
                 −7.49 
               
               
                 GCB_1026 
                 Training 
                 9.54 
                 10.20 
                 13.52 
                 −7.63 
               
               
                 GCB_1037 
                 Training 
                 6.34 
                 8.79 
                 12.57 
                 −6.17 
               
               
                 GCB_1039 
                 Training 
                 8.71 
                 9.94 
                 13.28 
                 −7.27 
               
               
                 GCB_1049 
                 Validation 
                 10.53 
                 8.18 
                 12.60 
                 −7.41 
               
               
                 GCB_1051 
                 Validation 
                 7.63 
                 10.18 
                 12.76 
                 −6.86 
               
               
                 GCB_1058 
                 Validation 
                 8.61 
                 9.04 
                 12.80 
                 −6.98 
               
               
                 GCB_1060 
                 Validation 
                 10.23 
                 9.38 
                 12.96 
                 −7.59 
               
               
                 GCB_412 
                 Training 
                 8.79 
                 7.92 
                 13.09 
                 −6.90 
               
               
                 GCB_415 
                 Training 
                 10.72 
                 8.57 
                 11.99 
                 −7.41 
               
               
                 GCB_421 
                 Training 
                 9.23 
                 5.26 
                 12.20 
                 −6.39 
               
               
                 GCB_424 
                 Training 
                 11.14 
                 8.46 
                 12.44 
                 −7.62 
               
               
                 GCB_433 
                 Training 
                 9.26 
                 8.52 
                 12.64 
                 −7.07 
               
               
                 GCB_434 
                 Training 
                 9.73 
                 10.13 
                 12.54 
                 −7.48 
               
               
                 GCB_438 
                 Validation 
                 9.60 
                 9.99 
                 12.51 
                 −7.41 
               
               
                 GCB_459 
                 Validation 
                 10.51 
                 7.75 
                 11.37 
                 −7.07 
               
               
                 GCB_470 
                 Validation 
                 9.56 
                 6.63 
                 12.23 
                 −6.74 
               
               
                 GCB_479 
                 Validation 
                 7.77 
                 4.71 
                 13.07 
                 −6.01 
               
               
                 GCB_492 
                 Training 
                 8.82 
                 9.52 
                 12.34 
                 −7.04 
               
               
                 GCB_517 
                 Validation 
                 9.92 
                 6.96 
                 12.76 
                 −7.03 
               
               
                 GCB_523 
                 Training 
                 6.59 
                 9.17 
                 12.77 
                 −6.35 
               
               
                 GCB_524 
                 Training 
                 10.00 
                 7.83 
                 12.51 
                 −7.16 
               
               
                 GCB_529 
                 Training 
                 5.61 
                 7.93 
                 10.77 
                 −5.41 
               
               
                 GCB_533 
                 Training 
                 9.55 
                 5.54 
                 12.44 
                 −6.59 
               
               
                 GCB_537 
                 Validation 
                 8.25 
                 10.25 
                 13.29 
                 −7.18 
               
               
                 GCB_543 
                 Validation 
                 9.92 
                 8.85 
                 12.06 
                 −7.21 
               
               
                 GCB_545 
                 Training 
                 9.69 
                 4.91 
                 12.90 
                 −6.62 
               
               
                 GCB_549 
                 Validation 
                 7.86 
                 8.88 
                 12.15 
                 −6.58 
               
               
                 GCB_550 
                 Validation 
                 10.64 
                 9.53 
                 12.24 
                 −7.60 
               
               
                 GCB_553 
                 Validation 
                 10.14 
                 9.05 
                 12.63 
                 −7.44 
               
               
                 GCB_565 
                 Validation 
                 9.08 
                 10.80 
                 13.42 
                 −7.57 
               
               
                 GCB_572 
                 Training 
                 8.93 
                 10.03 
                 12.58 
                 −7.21 
               
               
                 GCB_617 
                 Validation 
                 9.27 
                 7.80 
                 13.17 
                 −7.05 
               
               
                 GCB_618 
                 Training 
                 7.23 
                 9.11 
                 13.32 
                 −6.66 
               
               
                 GCB_619 
                 Validation 
                 9.63 
                 9.63 
                 12.12 
                 −7.27 
               
               
                 GCB_623 
                 Training 
                 8.94 
                 9.07 
                 12.35 
                 −7.00 
               
               
                 GCB_627 
                 Validation 
                 9.72 
                 8.33 
                 11.85 
                 −7.02 
               
               
                 GCB_654 
                 Training 
                 7.04 
                 5.60 
                 10.00 
                 −5.30 
               
               
                 GCB_661 
                 Validation 
                 10.27 
                 7.92 
                 12.66 
                 −7.29 
               
               
                 GCB_669 
                 Training 
                 9.15 
                 9.29 
                 12.32 
                 −7.10 
               
               
                 GCB_672 
                 Training 
                 9.69 
                 7.36 
                 12.41 
                 −6.95 
               
               
                 GCB_674 
                 Validation 
                 9.93 
                 6.23 
                 12.33 
                 −6.81 
               
               
                 GCB_675 
                 Validation 
                 7.48 
                 8.46 
                 10.12 
                 −5.97 
               
               
                 GCB_681 
                 Training 
                 10.77 
                 9.52 
                 12.59 
                 −7.72 
               
               
                 GCB_688 
                 Validation 
                 8.01 
                 10.17 
                 9.94 
                 −6.40 
               
               
                 GCB_695 
                 Validation 
                 10.58 
                 9.38 
                 12.45 
                 −7.60 
               
               
                 GCB_698 
                 Validation 
                 10.44 
                 9.00 
                 11.99 
                 −7.39 
               
               
                 GCB_701 
                 Training 
                 9.38 
                 9.27 
                 13.10 
                 −7.33 
               
               
                 GCB_710 
                 Validation 
                 6.96 
                 5.59 
                 13.19 
                 −5.93 
               
               
                 GCB_711 
                 Training 
                 9.28 
                 8.49 
                 11.44 
                 −6.82 
               
               
                 GCB_722 
                 Training 
                 8.93 
                 9.51 
                 12.61 
                 −7.13 
               
               
                 GCB_724 
                 Training 
                 9.51 
                 8.39 
                 11.53 
                 −6.90 
               
               
                 GCB_731 
                 Validation 
                 8.82 
                 9.19 
                 12.20 
                 −6.95 
               
               
                 GCB_742 
                 Validation 
                 9.95 
                 9.37 
                 12.95 
                 −7.50 
               
               
                 GCB_744 
                 Training 
                 10.23 
                 10.11 
                 11.85 
                 −7.49 
               
               
                 GCB_745 
                 Training 
                 10.29 
                 9.71 
                 11.95 
                 −7.46 
               
               
                 GCB_747 
                 Validation 
                 9.83 
                 9.79 
                 13.06 
                 −7.56 
               
               
                 GCB_749 
                 Training 
                 8.57 
                 10.27 
                 12.55 
                 −7.14 
               
               
                 GCB_758 
                 Validation 
                 6.88 
                 5.69 
                 12.51 
                 −5.78 
               
               
                 GCB_772 
                 Validation 
                 9.92 
                 7.28 
                 12.25 
                 −6.98 
               
               
                 GCB_777 
                 Validation 
                 9.03 
                 9.63 
                 11.69 
                 −6.99 
               
               
                 GCB_792 
                 Training 
                 9.49 
                 9.06 
                 12.08 
                 −7.12 
               
               
                 GCB_795 
                 Validation 
                 11.12 
                 9.02 
                 11.60 
                 −7.54 
               
               
                 GCB_797 
                 Validation 
                 8.42 
                 5.90 
                 12.84 
                 −6.38 
               
               
                 GCB_803 
                 Validation 
                 7.33 
                 10.11 
                 13.18 
                 −6.84 
               
               
                 GCB_810 
                 Training 
                 10.00 
                 8.22 
                 13.13 
                 −7.35 
               
               
                 GCB_817 
                 Training 
                 8.60 
                 10.16 
                 11.09 
                 −6.82 
               
               
                 GCB_818 
                 Training 
                 9.14 
                 7.78 
                 12.23 
                 −6.81 
               
               
                 GCB_819 
                 Validation 
                 9.08 
                 8.63 
                 13.22 
                 −7.15 
               
               
                 GCB_821 
                 Validation 
                 10.05 
                 9.81 
                 12.41 
                 −7.50 
               
               
                 GCB_832 
                 Training 
                 8.83 
                 6.91 
                 12.47 
                 −6.61 
               
               
                 GCB_836 
                 Validation 
                 9.49 
                 7.86 
                 11.46 
                 −6.78 
               
               
                 GCB_840 
                 Training 
                 9.45 
                 5.02 
                 11.74 
                 −6.33 
               
               
                 GCB_847 
                 Training 
                 9.41 
                 8.77 
                 12.55 
                 −7.14 
               
               
                 GCB_860 
                 Training 
                 9.02 
                 6.66 
                 11.54 
                 −6.43 
               
               
                 GCB_871 
                 Training 
                 6.60 
                 4.46 
                 11.16 
                 −5.20 
               
               
                 GCB_874 
                 Training 
                 10.39 
                 9.13 
                 11.65 
                 −7.33 
               
               
                 GCB_995 
                 Validation 
                 8.52 
                 9.35 
                 12.22 
                 −6.89 
               
               
                 PMBL_1006 
                 Validation 
                 8.72 
                 4.67 
                 10.94 
                 −5.86 
               
               
                 PMBL_1024 
                 Validation 
                 9.30 
                 8.47 
                 10.89 
                 −6.71 
               
               
                 PMBL_1048 
                 Validation 
                 10.30 
                 4.98 
                 12.18 
                 −6.68 
               
               
                 PMBL_1053 
                 Training 
                 8.75 
                 9.78 
                 11.12 
                 −6.81 
               
               
                 PMBL_484 
                 Training 
                 8.25 
                 4.96 
                 13.62 
                 −6.32 
               
               
                 PMBL_546 
                 Validation 
                 9.66 
                 6.07 
                 11.73 
                 −6.57 
               
               
                 PMBL_570 
                 Training 
                 10.58 
                 8.54 
                 12.70 
                 −7.50 
               
               
                 PMBL_621 
                 Training 
                 9.39 
                 9.94 
                 12.96 
                 −7.43 
               
               
                 PMBL_638 
                 Training 
                 9.81 
                 8.35 
                 11.37 
                 −6.95 
               
               
                 PMBL_691 
                 Validation 
                 8.37 
                 7.51 
                 10.17 
                 −6.10 
               
               
                 PMBL_791 
                 Validation 
                 9.29 
                 8.65 
                 11.56 
                 −6.88 
               
               
                 PMBL_824 
                 Validation 
                 9.87 
                 7.19 
                 13.28 
                 −7.16 
               
               
                 PMBL_994 
                 Training 
                 11.27 
                 6.73 
                 12.43 
                 −7.35 
               
               
                 PMBL_998 
                 Training 
                 7.92 
                 8.34 
                 13.19 
                 −6.72 
               
               
                 UC_DLBCL_1001 
                 Validation 
                 8.25 
                 5.63 
                 12.76 
                 −6.26 
               
               
                 UC_DLBCL_1004 
                 Validation 
                 9.01 
                 7.01 
                 13.09 
                 −6.81 
               
               
                 UC_DLBCL_1007 
                 Training 
                 11.42 
                 6.73 
                 12.97 
                 −7.51 
               
               
                 UC_DLBCL_1018 
                 Training 
                 7.77 
                 4.58 
                 12.71 
                 −5.91 
               
               
                 UC_DLBCL_1041 
                 Validation 
                 7.90 
                 4.33 
                 13.38 
                 −6.05 
               
               
                 UC_DLBCL_1054 
                 Training 
                 10.41 
                 8.72 
                 11.48 
                 −7.23 
               
               
                 UC_DLBCL_306 
                 Validation 
                 9.42 
                 6.54 
                 12.36 
                 −6.71 
               
               
                 UC_DLBCL_310 
                 Training 
                 9.97 
                 5.50 
                 12.27 
                 −6.69 
               
               
                 UC_DLBCL_449 
                 Validation 
                 10.01 
                 5.37 
                 12.17 
                 −6.65 
               
               
                 UC_DLBCL_458 
                 Training 
                 7.50 
                 5.79 
                 9.60 
                 −5.40 
               
               
                 UC_DLBCL_460 
                 Validation 
                 10.26 
                 8.27 
                 12.29 
                 −7.27 
               
               
                 UC_DLBCL_491 
                 Training 
                 9.43 
                 4.73 
                 12.39 
                 −6.40 
               
               
                 UC_DLBCL_528 
                 Validation 
                 8.42 
                 6.19 
                 11.63 
                 −6.18 
               
               
                 UC_DLBCL_615 
                 Validation 
                 8.44 
                 9.01 
                 12.80 
                 −6.92 
               
               
                 UC_DLBCL_625 
                 Training 
                 10.43 
                 8.27 
                 12.62 
                 −7.39 
               
               
                 UC_DLBCL_664 
                 Training 
                 9.80 
                 8.74 
                 12.72 
                 −7.29 
               
               
                 UC_DLBCL_671 
                 Training 
                 9.42 
                 5.26 
                 11.53 
                 −6.32 
               
               
                 UC_DLBCL_682 
                 Training 
                 9.01 
                 4.73 
                 12.33 
                 −6.26 
               
               
                 UC_DLBCL_683 
                 Training 
                 8.85 
                 8.23 
                 12.57 
                 −6.87 
               
               
                 UC_DLBCL_684 
                 Validation 
                 9.62 
                 8.78 
                 12.76 
                 −7.25 
               
               
                 UC_DLBCL_748 
                 Validation 
                 7.60 
                 5.79 
                 9.55 
                 −5.42 
               
               
                 UC_DLBCL_751 
                 Training 
                 6.40 
                 9.91 
                 13.14 
                 −6.50 
               
               
                 UC_DLBCL_808 
                 Training 
                 9.44 
                 7.01 
                 13.09 
                 −6.95 
               
               
                 UC_DLBCL_831 
                 Validation 
                 9.45 
                 5.81 
                 11.58 
                 −6.43 
               
               
                 UC_DLBCL_834 
                 Training 
                 8.52 
                 7.66 
                 11.77 
                 −6.50 
               
               
                 UC_DLBCL_838 
                 Validation 
                 8.49 
                 4.60 
                 12.56 
                 −6.11 
               
               
                 UC_DLBCL_851 
                 Validation 
                 7.50 
                 4.82 
                 8.19 
                 −4.94 
               
               
                 UC_DLBCL_854 
                 Validation 
                 8.35 
                 5.82 
                 12.59 
                 −6.29 
               
               
                 UC_DLBCL_855 
                 Training 
                 9.56 
                 5.44 
                 12.08 
                 −6.51 
               
               
                 UC_DLBCL_856 
                 Validation 
                 6.81 
                 7.49 
                 9.32 
                 −5.42 
               
               
                   
               
            
           
         
       
     
     In order to visualize the predictive power of the model, the 200 samples were ranked according to their survival predictor scores and divided into four quartiles. Kaplan-Meier plots of overall survival probability show clear differences in survival rate between these four quartiles ( FIG. 12 ). 
     Example 9 
     Development of an MCL Survival Predictor Using Gene Expression Data from Affymetrix U133A and U133B Microarrays 
     The connection between higher expression of proliferation genes and worse survival in MCL had previously been documented and validated (Rosenwald 2003). A cluster of proliferation genes had been identified in the DLBCL samples used to create the DLBCL survival predictor described in Example 7. By averaging the expression of these genes, a proliferation gene expression signature value had been developed for the DLBCL samples. The correlation of this signature with each probe set on the U133A and U133B microarrays was determined, and the 22 genes for which the correlation was greater than 0.5 were labeled proliferation genes. The correlation between expression of these proliferation genes and survival in 21 MCL samples was estimated using the Cox proportional hazards model. Table 2377 lists these 21 MCL samples. 
                                 TABLE 2377                   Length of follow-up   Status at   Used in creating       Sample ID #   (years)   follow-up   survival predictor?                  MCL_1012   3.19   Alive   Yes       MCL_1091   3.03   Alive   Yes       MCL_1114   0.59   Dead   Yes       MCL_1128   0.43   Dead   Yes       MCL_1150   3.21   Dead   Yes       MCL_1162   0.78   Alive   Yes       MCL_1166   0.53   Dead   Yes       MCL_1194   0.55   Alive   Yes       MCL_885   1.19   Alive   Yes       MCL_918   1.95   Dead   Yes       MCL_924   5.48   Dead   Yes       MCL_925   7.23   Alive   Yes       MCL_926   5.18   Dead   Yes       MCL_936   2.80   Alive   Yes       MCL_939   1.07   Dead   Yes       MCL_953   2.31   Dead   Yes       MCL_956   1.40   Dead   Yes       MCL_964   0.75   Alive   Yes       MCL_966   0.21   Dead   Yes       MCL_968   1.59   Dead   Yes       MCL_970   5.02   Dead   Yes                    
Out of the 22 proliferation genes, 11 were significant at a 0.001 level. The expression level of these 11 genes in each of the 21 MCL samples was averaged to generate a proliferation gene expression signature value. No other genes represented on the U133A or U133B microarrays correlated with MCL survival to an extent greater than would be expected by chance, so the final model included only proliferation genes. The 11 genes used to generate the model are presented in Table 2378.
 
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 2378 
               
               
                   
                   
               
               
                   
                 Signature 
                 UNIQID 
                 Gene Symbol 
               
               
                   
                   
               
             
            
               
                   
                 Proliferation 
                 1097290 
                 CIRH1A 
               
               
                   
                 Proliferation 
                 1101295 
                 FLJ40629 
               
               
                   
                 Proliferation 
                 1119729 
                 TK1 
               
               
                   
                 Proliferation 
                 1120153 
                 LMNB1 
               
               
                   
                 Proliferation 
                 1120494 
                 CDC6 
               
               
                   
                 Proliferation 
                 1124745 
                 KIAA0056 
               
               
                   
                 Proliferation 
                 1126148 
                 DKFZp586E1120 
               
               
                   
                 Proliferation 
                 1130618 
                 TPI1 
               
               
                   
                 Proliferation 
                 1134753 
                 WHSC1 
               
               
                   
                 Proliferation 
                 1139654 
                 ECT2 
               
               
                   
                 Proliferation 
                 1140632 
                 IMAGE:52707 
               
               
                   
                   
               
            
           
         
       
     
     A survival predictor score for MCL was generated using the following equation:
 
Survival predictor score=1.66*(proliferation gene expression signature value).
 
This model was associated with survival in a statistically significant manner (p=0.00018). To illustrate the significance of the model in predicting survival, the 21 MCL samples were divided into two equivalent groups based on their survival predictor scores. Those samples with survival predictor scores above the median were placed in the high proliferation group, while those with survival predictor scores below the median were placed in the low proliferation group.  FIG. 13  illustrates the Kaplan Meier survival estimates for these two groups. Median survival for the high proliferation group was 1.07 years, while median survival for the low proliferation group was 5.18 years.
 
     Example 10 
     Development of an MCL Survival Predictor Using Gene Expression Data from the Lymph Dx Microarray 
     A set of 21 genes associated with proliferation and poor prognosis in MCL had been identified previously (Rosenwald 2003). Of these 21 genes, only four were represented on the Lymph Dx microarray. In order to find a larger set of genes on the Lymph Dx microarray associated with survival in MCL, Lymphochip expression data (Rosenwald 2003) was re-analyzed and another set of proliferation genes whose expression levels were correlated with poor survival in MCL were identified. Thirteen of these genes were represented on the Lymph Dx microarray (median expression&gt;6 on log 2  scale). These 13 genes are listed in Table 2379. 
     
       
         
           
               
               
               
               
             
               
                 TABLE 2379 
               
               
                   
               
               
                 Signature 
                 UNIQID 
                 Unigene ID Build 167 
                 Gene symbol 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                 Proliferation 
                 1119294 
                 156346 
                 TOP2A 
               
               
                 Proliferation 
                 1119729 
                 164457 
                 TK1 
               
               
                 Proliferation 
                 1120153 
                 89497 
                 LMNB1 
               
               
                 Proliferation 
                 1121276 
                 24529 
                 CHEK1 
               
               
                 Proliferation 
                 1123358 
                 442658 
                 AURKB 
               
               
                 Proliferation 
                 1124178 
                 446579 
                 HSPCA 
               
               
                 Proliferation 
                 1124563 
                 249441 
                 WEE1 
               
               
                 Proliferation 
                 1130799 
                 233952 
                 PSMA7 
               
               
                 Proliferation 
                 1131274 
                 374378 
                 CKS1B 
               
               
                 Proliferation 
                 1131778 
                 396393 
                 UBE2S 
               
               
                 Proliferation 
                 1132449 
                 250822 
                 STK6 
               
               
                 Proliferation 
                 1135229 
                 367676 
                 DUT 
               
               
                 Proliferation 
                 1136585 
                 80976 
                 MKI67 
               
               
                   
               
            
           
         
       
     
     The expression levels of the 13 genes listed in Table 2379 on the Lymph Dx microarray were transformed into the log 2  scale and averaged to form a proliferation gene expression signature value. This was used to generate a survival predictor score using the following equation:
 
Survival predictor score=1.66*(proliferation gene expression signature value)
 
     For the 21 MCL samples analyzed, the survival predictor score had a mean of 14.85 and a standard deviation of 1.13. Even in this limited sample set, the survival predictor score was significantly associated with prognosis (p=0.0049), with each unit increase in the score corresponding to a 2.7 fold increase in the relative risk of death. Data for all 21 samples is shown in Table 2380. 
     
       
         
           
               
               
               
               
             
               
                   
                 TABLE 2380 
               
               
                   
                   
               
               
                   
                   
                 Proliferation 
                 Survival predictor 
               
               
                   
                 Sample ID # 
                 signature value 
                 score 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
            
               
                   
                 MCL_1012 
                 8.83 
                 14.658 
               
               
                   
                 MCL_1091 
                 8.81 
                 14.625 
               
               
                   
                 MCL_1114 
                 10.39 
                 17.247 
               
               
                   
                 MCL_1128 
                 10.12 
                 16.799 
               
               
                   
                 MCL_1150 
                 8.33 
                 13.828 
               
               
                   
                 MCL_1162 
                 8.15 
                 13.529 
               
               
                   
                 MCL_1166 
                 9.40 
                 15.604 
               
               
                   
                 MCL_1194 
                 7.44 
                 12.350 
               
               
                   
                 MCL_885 
                 8.68 
                 14.409 
               
               
                   
                 MCL_918 
                 9.33 
                 15.488 
               
               
                   
                 MCL_924 
                 8.35 
                 13.861 
               
               
                   
                 MCL_925 
                 8.86 
                 14.708 
               
               
                   
                 MCL_926 
                 8.14 
                 13.512 
               
               
                   
                 MCL_936 
                 8.56 
                 14.21 
               
               
                   
                 MCL_939 
                 9.14 
                 15.172 
               
               
                   
                 MCL_953 
                 9.25 
                 15.355 
               
               
                   
                 MCL_956 
                 9.35 
                 15.521 
               
               
                   
                 MCL_964 
                 9.74 
                 16.168 
               
               
                   
                 MCL_966 
                 8.76 
                 14.542 
               
               
                   
                 MCL_968 
                 9.10 
                 15.106 
               
               
                   
                 MCL_970 
                 9.27 
                 15.388 
               
               
                   
                   
               
            
           
         
       
     
     To illustrate the significance of the model in predicting survival, the 21 MCL samples were divided into two equivalent groups based on their survival predictor scores. Those samples with survival predictor scores above the median were placed in the high proliferation group, while those with survival predictor scores below the median were placed in the low proliferation group.  FIG. 14  illustrates the Kaplan Meier survival estimates for these two groups. 
     Example 11 
     Identification of Lymphoma Samples as MCL Based on Bayesian Analysis of Gene Expression Data from Affymetrix U133A and U133B Microarrays 
     A statistical method based on Bayesian analysis was developed to distinguish MCL samples from samples belonging to other lymphoma types based on gene expression profiling. This method was developed using the gene expression data obtained in Example 1 for the following lymphoma types: ABC, GCB, PMBL, BL, FH, FL, MALT, MCL, PTLD, SLL, and splenic marginal zone lymphoma (splenic). Tables 1707-1741 (discussed in Example 1) provide gene expression data for samples within each of these lymphoma types, including the expression level of each gene and the difference in expression of each gene between types. Tables 1710, 1715, and 1723 (corresponding to FL, MCL, and DLBCL, respectively) include the correlation between expression of each gene and survival. 
     To determine the lymphoma type of a sample, a series of predictor models are generated. Each predictor model calculates the probability that the sample belongs to a first lymphoma type rather than a second lymphoma type. A method was developed to determine whether a sample was MCL, or one of the following lymphoma types: ABC, BL, FH, FL, GCB, MALT, PMBL, PTLD, SLL, or splenic. This method required ten different predictor models, each designed to determine whether the sample belonged to MCL or one of the other ten lymphoma types (e.g., MCL vs. ABC, MCL vs. BL, etc.). 
     Several of the lymphoma samples analyzed displayed a tendency towards elevated or reduced expression of genes from the lymph node and proliferation gene expression signatures. These genes are likely to be highly differentially expressed between the lymphoma types, but they do not serve as good predictor genes because they are often variably expressed within a single lymphoma type. For this reason, any gene that displayed a correlation with the proliferation or lymph node signatures was eliminated from consideration. 
     For each lymphoma type pair (e.g., MCL vs. ABC, MCL vs. FL, etc.), 20 genes were identified that exhibited the greatest difference in expression between MCL and the second lymphoma type according to a Student&#39;s t-test. The choice to use 20 genes was arbitrary. For each sample X, the 20 genes were used to generate a linear predictor score (LPS) according to the following formula: 
                 LPS   ⁡     (   X   )       =       ∑     j   =   1     20     ⁢       t   j     ⁢     X   j           ,         
where X j  is the expression of gene j in sample X and t j  is the t-statistic for the difference in expression of gene j between a first lymphoma type and a second lymphoma type. This is merely one method for generating an LPS. Others methods include linear discriminant analysis (Dudoit 2002), support vector machines (Furey 2000), or shrunken centroids (Tibshirani 2002). In addition, there is no requirement that a t-statistic be used as the scaling factor.
 
     After an LPS had been formulated for each lymphoma sample, the mean and standard deviation of these LPS&#39;s was calculated for each lymphoma type. For a new sample X, Bayes&#39; rule can be used to estimate the probability that the sample belongs to a first lymphoma type rather than a second lymphoma type ( FIG. 15 ). In this example, Bayes&#39; rule was used to calculate the probability q that sample X was MCL rather than a second lymphoma type using the following equation: 
               q   ⁡     (     X   ⁢           ⁢   is   ⁢           ⁢   type   ⁢           ⁢   1     )       =       ϕ   ⁡     (         LPS   ⁡     (   X   )       ;       μ   ^     1       ,       σ   ^     1       )           ϕ   ⁡     (         LPS   ⁡     (   X   )       ;       μ   ^     1       ,       σ   ^     1       )       +     ϕ   ⁡     (         LPS   ⁡     (   X   )       ;       μ   ^     2       ,       σ   ^     2       )                 
where type 1 is MCL, type 2 is one of the other nine lymphoma types, φ(x; μ, σ) is the normal density function with mean μ and standard deviation σ, {circumflex over (μ)} 1  and {circumflex over (σ)} 1  are the sample mean and variance of the LPS values for lymphoma type 1, and {circumflex over (μ)} 2  and {circumflex over (σ)} 2  are the sample mean and variance of the LPS values for lymphoma type 2.
 
     This method was used to develop ten predictor models, one for each pairing of MCL and a second lymphoma type. A sample was classified as MCL if each of the ten predictors generated at least a 90% probability that the sample was MCL. If any of the ten predictors indicated a probability of less than 90%, the sample was classified as non-MCL. 
     The 10 sets of 20 genes that were included in these models and the t-statistics for each gene are presented in Tables 2381-2490. 
     
       
         
           
               
             
               
                 TABLE 2381 
               
             
            
               
                   
               
               
                 MCL vs. ABC predictor genes 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Gene 
                   
                 GENBANK 
                 Affymetrix probe 
                   
               
               
                 UNIQID 
                 symbol 
                 gi 
                 Accession 
                 set ID 
                 Scale Factor 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1103711 
                   
                 10433184 
                 AK021895.1 
                 232478_at 
                 17.88496416 
               
               
                 1133111 
                 PDE9A 
                 48762717 
                 NM_001001567.1 
                 205593_s_at 
                 17.61579873 
               
               
                 1137987 
                 PLXNB1 
                 41152087 
                 NM_002673.3 
                 215807_s_at 
                 17.47030156 
               
               
                 1132835 
                 SOX11 
                 30581115 
                 NM_003108.3 
                 204915_s_at 
                 16.89404131 
               
               
                 1109505 
                 MGC39372 
                 19263721 
                 BC025340.1 
                 239186_at 
                 15.78111902 
               
               
                 1139054 
                 ZBED5 
                 49574209 
                 NM_021211.2 
                 218263_s_at 
                 15.77800815 
               
               
                 1119361 
                 TIA1 
                 11863160 
                 NM_022037.1 
                 201448_at 
                 15.68070962 
               
               
                 1115226 
                 KIAA1683 
                 144922706 
                 NM_025249.2 
                 223600_s_at 
                 15.67954057 
               
               
                 1101211 
                 STRBP 
                 21361744 
                 NM_018387.2 
                 229513_at 
                 15.4183527 
               
               
                 1118963 
                   
                 11084506 
                 BF196503.1 
                 65472_at 
                 15.36802586 
               
               
                 1096503 
                 C9orf45 
                 12005727 
                 AF251293.1 
                 223522_at 
                 14.64776335 
               
               
                 1127849 
                 SNN 
                 83627728 
                 NM_003498.4 
                 218032_at 
                 14.54859775 
               
               
                 1099204 
                   
                 5817123 
                 AL110204.1 
                 227121_at 
                 14.32724822 
               
               
                 1098840 
                 CCDC50 
                 41281910 
                 NM_178335.1 
                 226713_at 
                 14.10346944 
               
               
                 1139444 
                 RABL2B 
                 51317348 
                 NM_001003789.1 
                 219151_s_at 
                 14.10016196 
               
               
                 1106855 
                 KIAA1909 
                 148529024 
                 NM_052909.3 
                 236255_at 
                 13.9504946 
               
               
                 1126695 
                 LOC730273 
                 113419660 
                 XM_001124203.1 
                 216000_at 
                 13.92285415 
               
               
                 1120137 
                 FCGBP 
                 154146261 
                 NM_003890.2 
                 203240_at 
                 13.86147896 
               
               
                 1133011 
                 TMSL8 
                 72255577 
                 NM_021992.2 
                 205347_s_at 
                 13.74377784 
               
               
                 1133192 
                 RASGRP3 
                 24762238 
                 NM_170672.1 
                 205801_s_at 
                 −17.09085725 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2382 
               
             
            
               
                   
               
               
                 MCL vs. BL predictor genes 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Gene 
                   
                 GENBANK 
                 Affymetrix probe 
                   
               
               
                 UNIQID 
                 symbol 
                 gi 
                 Accession 
                 set ID 
                 Scale Factor 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1120900 
                 EPHB6 
                 56119211 
                 NM_004445.2 
                 204718_at 
                 13.43582327 
               
               
                 1112061 
                 SDK2 
                 48255893 
                 NM_019064.3 
                 242064_at 
                 12.73065392 
               
               
                 1109505 
                 MGC39372 
                 19263721 
                 BC025340.1 
                 239186_at 
                 12.63674985 
               
               
                 1133099 
                 DNASE1L3 
                 58331226 
                 NM_004944.2 
                 205554_s_at 
                 12.43333984 
               
               
                 1106855 
                 KIAA1909 
                 148529024 
                 NM_052909.3 
                 236255_at 
                 12.32623489 
               
               
                 1110070 
                   
                 8168250 
                 AW977010.1 
                 239803_at 
                 12.05416064 
               
               
                 1121739 
                 ZNF135 
                 34419632 
                 NM_003436.2 
                 206142_at 
                 11.90460363 
               
               
                 1098840 
                 CCDC50 
                 41281910 
                 NM_178335.1 
                 226713_at 
                 11.90309143 
               
               
                 1132833 
                 SOX11 
                 30581115 
                 NM_003108.3 
                 204913_s_at 
                 11.60864812 
               
               
                 1121693 
                 PLCH2 
                 78499632 
                 NM_014638.2 
                 206080_at 
                 11.33634052 
               
               
                 1123760 
                 LILRA4 
                 47519952 
                 NM_012276.3 
                 210313_at 
                 11.18744726 
               
               
                 1125964 
                 TMEM63A 
                 7662307 
                 NM_014698.1 
                 214833_at 
                 11.14762675 
               
               
                 1112306 
                   
                 6139540 
                 AW135407.1 
                 242354_at 
                 11.02434114 
               
               
                 1096070 
                 DNMT3A 
                 28559066 
                 NM_022552.3 
                 222640_at 
                 10.98991879 
               
               
                 1129943 
                 ZNF506 
                 149944539 
                 NM_001099269.1 
                 221626_at 
                 10.72494956 
               
               
                 1118749 
                   
                 11125347 
                 AJ296290.1 
                 39313_at 
                 10.64623382 
               
               
                 1098954 
                 MOBKL2B 
                 41350329 
                 NM_024761.3 
                 226844_at 
                 10.46164401 
               
               
                 1134749 
                 ZMYND8 
                 34335265 
                 NM_012408.3 
                 209049_s_at 
                 10.40948157 
               
               
                 1131860 
                 BIN1 
                 21536381 
                 NM_004305.2 
                 202931_x_at 
                 10.31084561 
               
               
                 1123148 
                 TGFBR2 
                 133908632 
                 NM_001024847.2 
                 208944_at 
                 10.2956213 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2383 
               
             
            
               
                   
               
               
                 MCL vs. FH predictor genes 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Gene 
                   
                 GENBANK 
                 Affymetrix probe 
                   
               
               
                 UNIQID 
                 symbol 
                 gi 
                 Accession 
                 set ID 
                 Scale Factor 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1132834 
                 SOX11 
                 30581115 
                 NM_003108.3 
                 204914_s_at 
                 24.3531072 
               
               
                 1100873 
                 WNT3 
                 21536426 
                 NM_030753.3 
                 229103_at 
                 16.83342764 
               
               
                 1109603 
                   
                 4971784 
                 A1694444.1 
                 239292_at 
                 13.02401995 
               
               
                 1139411 
                 OSBPL10 
                 23111057 
                 NM_017784.3 
                 219073_s_at 
                 12.54369577 
               
               
                 1106855 
                 KIAA1909 
                 148529024 
                 NM_052909.3 
                 236255_at 
                 12.10316361 
               
               
                 1125193 
                 CNR1 
                 38683843 
                 NM_016083.3 
                 213436_at 
                 12.070579 
               
               
                 1137450 
                 ALOX5 
                 62912458 
                 NM_000698.2 
                 214366_s_at 
                 11.74571823 
               
               
                 1100258 
                 KLHL14 
                 55741642 
                 NM_020805.1 
                 228377_at 
                 11.60998697 
               
               
                 1133167 
                 ZNF107 
                 62243639 
                 NM_001013746.1 
                 205739_x_at 
                 11.52931491 
               
               
                 1136831 
                 PPFIBP2 
                 57163846 
                 NM_003621.1 
                 212841_s_at 
                 11.50062692 
               
               
                 1138222 
                 CD24 
                 73623396 
                 NM_013230.2 
                 216379_x_at 
                 10.99674674 
               
               
                 1099437 
                 PTPRJ 
                 148728159 
                 NM_001098503.1 
                 227396_at 
                 10.90797288 
               
               
                 1140236 
                 FCRL2 
                 74048626 
                 NM_138738.2 
                 221239_s_at 
                 10.77082801 
               
               
                 1114109 
                 CLECL1 
                 40548404 
                 NM_172004.2 
                 244413_at 
                 10.65867119 
               
               
                 1098277 
                 PRICKLE1 
                 23308518 
                 NM_153026.1 
                 226065_at 
                 10.55457068 
               
               
                 1135138 
                 CD24 
                 73623396 
                 NM_013230.2 
                 209771_x_at 
                 10.41999962 
               
               
                 1103304 
                 L0C439949 
                 113421296 
                 XM_001128367.1 
                 232001_at 
                 −10.46625233 
               
               
                 1128460 
                 PITPNC1 
                 32307139 
                 NM_012417.2 
                 219155_at 
                 −10.91106245 
               
               
                 1121953 
                 KIAA0125 
                 20302136 
                 NM_014792.2 
                 206478_at 
                 −11.22466255 
               
               
                 1129281 
                 FAM30A 
                 6841343 
                 AF161538.1 
                 220377_at 
                 −15.54465448 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2384 
               
             
            
               
                   
               
               
                 MCL vs. FL predictor genes 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Gene 
                   
                 GENBANK 
                 Affymetrix probe 
                   
               
               
                 UNIQID 
                 symbol 
                 gi 
                 Accession 
                 set ID 
                 Scale Factor 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1132835 
                 SOX11 
                 30581115 
                 NM_003108.3 
                 204915_s_at 
                 22.14208817 
               
               
                 1096070 
                 DNMT3A 
                 28559066 
                 NM_022552.3 
                 222640_at 
                 20.53740132 
               
               
                 1103711 
                   
                 10433184 
                 AK021895.1 
                 232478_at 
                 20.49880004 
               
               
                 1137987 
                 PLXNB1 
                 41152087 
                 NM_002673.3 
                 215807_s_at 
                 18.38081568 
               
               
                 1109505 
                 MGC39372 
                 19263721 
                 BC025340.1 
                 239186_at 
                 17.17812448 
               
               
                 1098840 
                 CCDC50 
                 41281910 
                 NM_178335.1 
                 226713_at 
                 16.32703666 
               
               
                 1130926 
                 C5orf13 
                 4758865 
                 NM_004772.1 
                 201310_s_at 
                 15.34261878 
               
               
                 1096396 
                 SPG3A 
                 74024913 
                 NM_015915.3 
                 223340_at 
                 14.75437736 
               
               
                 1132734 
                 COL9A3 
                 119508425 
                 NM_001853.3 
                 204724_s_at 
                 14.684583 
               
               
                 1139393 
                 OPN3 
                 71999130 
                 NM_014322.2 
                 219032_x_at 
                 14.39118445 
               
               
                 1115537 
                 CNFN 
                 26024194 
                 NM_032488.2 
                 224329_s_at 
                 14.18446144 
               
               
                 1102215 
                 PRICKLE1 
                 23308518 
                 NM_003105.3 
                 230708_at 
                 14.16246426 
               
               
                 1124585 
                 SORL1 
                 18379347 
                 NM_003105.3 
                 212560_at 
                 −14.33315955 
               
               
                 1137561 
                 HOXA1 
                 84697023 
                 NM_005522.4 
                 214639_s_at 
                 −15.38404642 
               
               
                 1100581 
                 BCL6 
                 21040323 
                 NM_001706.2 
                 228758_at 
                 −15.91666634 
               
               
                 1124646 
                 RFTN1 
                 41872576 
                 NM_015150.1 
                 212646_at 
                 −16.40577696 
               
               
                 1114543 
                   
                 5395779 
                 A1809213.1 
                 244887_at 
                 −17.60167863 
               
               
                 1120090 
                 BCL6 
                 21040323 
                 NM_001706.2 
                 203140_at 
                 −17.63091181 
               
               
                 1123731 
                 RGS13 
                 21464137 
                 NM_170672.1 
                 210258_at 
                 −22.41602151 
               
               
                 1133192 
                 RASGRP3 
                 24762238 
                 NM_170672.1 
                 205801_s_at 
                 −27.28308723 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2385 
               
             
            
               
                   
               
               
                 MCL vs. GCB predictor genes 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Gene 
                   
                 GENBANK 
                 Affymetrix probe 
                   
               
               
                 UNIQID 
                 symbol 
                 gi 
                 Accession 
                 set ID 
                 Scale Factor 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1098840 
                 CCDC50 
                 41281910 
                 NM_178335.1 
                 226713_at 
                 22.26488562 
               
               
                 1132835 
                 SOX11 
                 30581115 
                 NM_003108.3 
                 204915_s_at 
                 17.76179754 
               
               
                 1137987 
                 PLXNB1 
                 41152087 
                 NM_002673.3 
                 215807_s_at 
                 16.86845147 
               
               
                 1098954 
                 MOBKL2B 
                 41350329 
                 NM_024761.3 
                 226844_at 
                 16.65023669 
               
               
                 1103711 
                   
                 10433184 
                 AK021895.1 
                 232478_at 
                 15.64719784 
               
               
                 1096070 
                 DNMT3A 
                 28559066 
                 NM_022552.3 
                 222640_at 
                 15.22540494 
               
               
                 1139393 
                 OPN3 
                 71999130 
                 NM_014322.2 
                 219032_x_at 
                 14.64030565 
               
               
                 1127849 
                 SNN 
                 83627728 
                 NM_003498.4 
                 218032_at 
                 14.28242206 
               
               
                 1098156 
                 MAP3K1 
                 153945764 
                 NM_005921.1 
                 225927_at 
                 14.00049272 
               
               
                 1128845 
                 SIDT1 
                 116812583 
                 NM_017699.2 
                 219734_at 
                 13.96064416 
               
               
                 1129943 
                 ZNF506 
                 149944539 
                 NM_001099269.1 
                 221626_at 
                 13.85404507 
               
               
                 1140116 
                 ARHGAP24 
                 111154091 
                 NM_001025616.2 
                 221030_s_at 
                 13.81464172 
               
               
                 1106855 
                 KIAA1909 
                 148529024 
                 NM_052909.3 
                 236255_at 
                 13.74521849 
               
               
                 1120900 
                 EPHB6 
                 56119211 
                 NM_004445.2 
                 204718_at 
                 13.46567004 
               
               
                 1127371 
                   
                 4372199 
                 A1479031.1 
                 217164_at 
                 13.45735668 
               
               
                 1119361 
                 TIA1 
                 11863160 
                 NM_022037.1 
                 201448_at 
                 13.37376559 
               
               
                 1120854 
                 EDG1 
                 87196352 
                 NM_001400.3 
                 204642_at 
                 13.1047657 
               
               
                 1098277 
                 PRICKLE1 
                 23308518 
                 NM_153026.1 
                 226065_at 
                 13.04993076 
               
               
                 1140127 
                 TRIM6-TRIM34 
                 51477689 
                 NM_001003819.1 
                 221044_s_at 
                 12.66260609 
               
               
                 1100581 
                 BCL6 
                 21040323 
                 NM_001706.2 
                 228758_at 
                 −12.81251689 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2386 
               
             
            
               
                   
               
               
                 MCL vs. MALT predictor genes 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Gene 
                   
                 GENBANK 
                 Affymetrix probe 
                   
               
               
                 UNIQID 
                 symbol 
                 gi 
                 Accession 
                 set ID 
                 Scale Factor 
               
               
                   
               
               
                 1132834 
                 SOX11 
                 30581115 
                 NM_003108.3 
                 204914_s_at 
                 20.7489202 
               
               
                 1101987 
                 K1AA1909 
                 148529024 
                 NM_052909.3 
                 230441_at 
                 10.78991326 
               
               
                 1100873 
                 WNT3 
                 21536426 
                 NM_030753.3 
                 229103_at 
                 10.11845036 
               
               
                 1130764 
                 HNRNPA0 
                 52426775 
                 NM_006805.3 
                 201055_s_at 
                 9.432459453 
               
               
                 1102178 
                 H2BFXP 
                 115432116 
                 NR_003238.1 
                 230664_at 
                 9.035605572 
               
               
                 1098277 
                 PRICKLE1 
                 23308518 
                 NM_153026.1 
                 226065_at 
                 9.003360784 
               
               
                 1130926 
                 C5orf13 
                 4758865 
                 NM_004772.1 
                 201310_s_at 
                 8.712830747 
               
               
                 1098694 
                 SBK1 
                 67906173 
                 NM_001024401.2 
                 226548_at 
                 8.309789856 
               
               
                 1103711 
                   
                 10433184 
                 AK021895.1 
                 232478_at 
                 8.248526605 
               
               
                 1138099 
                 FADS3 
                 34304362 
                 NM_021727.3 
                 216080_s_at 
                 8.107440225 
               
               
                 1120854 
                 EDG1 
                 87196352 
                 NM_001400.3 
                 204642_at 
                 8.045872672 
               
               
                 1102215 
                 PRICKLE1 
                 23308518 
                 NM_153026.1 
                 230708_at 
                 8.032351578 
               
               
                 1121739 
                 ZNF135 
                 34419632 
                 NM_003436.2 
                 206142_at 
                 8.020919565 
               
               
                 1096070 
                 DNMT3A 
                 28559066 
                 NM_022552.3 
                 222640_at 
                 7.964477216 
               
               
                 1101211 
                 STRBP 
                 21361744 
                 NM_018387.2 
                 229513_at 
                 7.738742472 
               
               
                 1120825 
                 CHL1 
                 27894375 
                 NM_006614.2 
                 204591_at 
                 7.516130116 
               
               
                 1099437 
                 PTPRJ 
                 148728159 
                 NM_001098503.1 
                 227396_at 
                 7.209041652 
               
               
                 1096503 
                 C9orf45 
                 12005727 
                 AF251293.1 
                 223522_at 
                 7.171540413 
               
               
                 1135927 
                 LILRA2 
                 5803067 
                 NM_006866.1 
                 211102_s_at 
                 7.134470829 
               
               
                 1120645 
                 FADS3 
                 34304362 
                 NM_021727.3 
                 204257_at 
                 7.039952979 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2387 
               
             
            
               
                   
               
               
                 MCL vs. PMBL predictor genes 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Gene 
                   
                 GENBANK 
                 Affymetrix probe 
                   
               
               
                 UNIQID 
                 symbol 
                 gi 
                 Accession 
                 set ID 
                 Scale Factor 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1132834 
                 SOX11 
                 30581115 
                 NM_003108.3 
                 204914_s_at 
                 28.17593839 
               
               
                 1100873 
                 WNT3 
                 21536426 
                 NM_030753.3 
                 229103_at 
                 17.90004832 
               
               
                 1096503 
                 C9orf45 
                 12005727 
                 AF251293.1 
                 223522_at 
                 17.43982729 
               
               
                 1098840 
                 CCDC50 
                 41281910 
                 NM_178335.1 
                 226713_at 
                 17.37421052 
               
               
                 1124734 
                 ZNF238 
                 45439300 
                 NM_006352.3 
                 212774_at 
                 16.73821457 
               
               
                 1135102 
                 PRKCB1 
                 47157320 
                 NM_002738.5 
                 209685_s_at 
                 16.67436366 
               
               
                 1103711 
                   
                 10433184 
                 AK021895.1 
                 232478_at 
                 16.57202026 
               
               
                 1140416 
                 FAIM3 
                 34147517 
                 NM_005449.3 
                 221601_s_at 
                 15.64802242 
               
               
                 1121757 
                 ADRB2 
                 116686129 
                 NM_000024.4 
                 206170_at 
                 15.57336633 
               
               
                 1140236 
                 FCRL2 
                 74048626 
                 NM_138738.2 
                 221239_s_at 
                 15.20264513 
               
               
                 1099140 
                   
                 28835721 
                 BC047541.1 
                 227052_at 
                 15.11929571 
               
               
                 1099549 
                   
                 7154210 
                 AW516128.1 
                 227533_at 
                 14.92883027 
               
               
                 1139054 
                 ZBED5 
                 49574209 
                 NM_021211.2 
                 218263_s_at 
                 14.63422275 
               
               
                 1138818 
                 ILF3 
                 24234752 
                 NM_004516.2 
                 217804_s_at 
                 14.50621028 
               
               
                 1109444 
                   
                 31317247 
                 NM_006850.2 
                 239122_at 
                 14.20430672 
               
               
                 1124534 
                 GPATCH8 
                 50962881 
                 NM_001002909.1 
                 212485_at 
                 14.18537487 
               
               
                 1098277 
                 PRICKLE1 
                 23308518 
                 NM_153026.1 
                 226065_at 
                 13.98526258 
               
               
                 1131687 
                 TLK1 
                 33636697 
                 NM_012290.3 
                 202606_s_at 
                 13.97468703 
               
               
                 1125112 
                 PLCL2 
                 142369931 
                 NM_015184.3 
                 213309_at 
                 13.85714318 
               
               
                 1125397 
                 RABL4 
                 9257237 
                 NM_006860.2 
                 213784_at 
                 13.85049805 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2388 
               
             
            
               
                   
               
               
                 MCL vs. PTLD predictor genes 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Gene 
                   
                 GENBANK 
                 Affymetrix probe 
                   
               
               
                 UNIQID 
                 symbol 
                 gi 
                 Accession 
                 set ID 
                 Scale Factor 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1109603 
                   
                 14060141 
                 BG749488.1 
                 239292_at 
                 19.95553782 
               
               
                 1138222 
                 CD24 
                 73623396 
                 NM_013230.2 
                 216379_x_at 
                 15.95397369 
               
               
                 1135138 
                 CD24 
                 73623396 
                 NM_013230.2 
                 209771_x_at 
                 15.89198725 
               
               
                 1134230 
                 RASGRP2 
                 149158726 
                 NM_001098670.1 
                 208206_s_at 
                 15.80452978 
               
               
                 1139411 
                 OSBPL10 
                 23111057 
                 NM_017784.3 
                 219073_s_at 
                 14.32818885 
               
               
                 1140416 
                 FAIM3 
                 34147517 
                 NM_005449.3 
                 221601_s_at 
                 13.89685188 
               
               
                 1132834 
                 SOX11 
                 30581115 
                 NM_003108.3 
                 204914_s_at 
                 13.78424818 
               
               
                 1121739 
                 ZNFI35 
                 34419632 
                 NM_003436.2 
                 206142_at 
                 13.02195529 
               
               
                 1098156 
                 MAP3K1 
                 153945764 
                 NM_005921.1 
                 225927_at 
                 12.95032505 
               
               
                 1099270 
                 AFF3 
                 68348715 
                 NM_001025108.1 
                 227198_at 
                 12.7877735 
               
               
                 1139012 
                 MAP4K4 
                 46249361 
                 NM_004834.3 
                 218181_s_at 
                 12.70176225 
               
               
                 1120854 
                 EDG1 
                 87196352 
                 NM_001400.3 
                 204642_at 
                 12.25264341 
               
               
                 1120985 
                 ARHGAP25 
                 55770897 
                 NM_001007231.1 
                 204882_at 
                 12.04626201 
               
               
                 1115952 
                 ATXN1L 
                 21734020 
                 AL833385.1 
                 226095_s_at 
                 11.96299478 
               
               
                 1120825 
                 CHL1 
                 27894375 
                 NM_006614.2 
                 204591_at 
                 11.82402907 
               
               
                 1131636 
                 SPOCK2 
                 7662035 
                 NM_014767.1 
                 202524_s_at 
                 11.80417657 
               
               
                 1136706 
                 PCMTD2 
                 157388996 
                 NM_001104925.1 
                 212406_s_at 
                 11.74962191 
               
               
                 1113560 
                   
                 14589868 
                 NM_032966.1 
                 243798_at 
                 11.72049882 
               
               
                 1133851 
                 P4HA1 
                 63252885 
                 NM_000917.2 
                 207543_s_at 
                 −12.59876059 
               
               
                 1137459 
                 BCAT1 
                 72187658 
                 NM_005504.4 
                 214390_s_at 
                 −14.00465411 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2389 
               
             
            
               
                   
               
               
                 MCL vs. SLL predictor genes 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Gene 
                   
                 GENBANK 
                 Affymetrix probe 
                   
               
               
                 UNIQID 
                 symbol 
                 gi 
                 Accession 
                 set ID 
                 Scale Factor 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1132834 
                 SOX11 
                 30581115 
                 NM_003108.3 
                 204914_s_at 
                 23.59602107 
               
               
                 1101987 
                 K1AA1909 
                 148529024 
                 NM_052909.3 
                 230441_at 
                 14.50254794 
               
               
                 1103711 
                   
                 10433184 
                 AK021895.1 
                 232478_at 
                 13.31375894 
               
               
                 1096070 
                 DNMT3A 
                 28559066 
                 NM_022552.3 
                 222640_at 
                 12.37453972 
               
               
                 1130926 
                 C5orf13 
                 4758865 
                 NM_004772.1 
                 201310_s_at 
                 11.27840239 
               
               
                 1120645 
                 FADS3 
                 34304362 
                 NM_021727.3 
                 204257_at 
                 11.14057287 
               
               
                 1138099 
                 FADS3 
                 34304362 
                 NM_021727.3 
                 216080_s_at 
                 10.92729287 
               
               
                 1097887 
                 MAST4 
                 148727254 
                 NM_015183.1 
                 225611_at 
                 10.37913127 
               
               
                 1099941 
                   
                 15750678 
                 B1759100.1 
                 227985_at 
                 10.33953409 
               
               
                 1130373 
                 MAST4 
                 148727254 
                 NM_015183.1 
                 40016_g_at 
                 10.01524528 
               
               
                 1110957 
                 SYNE2 
                 118918402 
                 NM_015180.4 
                 240777_at 
                 9.865436185 
               
               
                 1130320 
                 MAST4 
                 148727254 
                 NM_015183.1 
                 222348_at 
                 9.807091644 
               
               
                 1124373 
                 LPIN1 
                 22027647 
                 NM_145693.1 
                 212274_at 
                 9.024985551 
               
               
                 1128813 
                 KREMEN2 
                 27437002 
                 NM_024507.2 
                 219692_at 
                 8.903791941 
               
               
                 1131130 
                 MARCKS 
                 153070259 
                 NM_002356.5 
                 201670_s_at 
                 8.688979176 
               
               
                 1120825 
                 CHL1 
                 27894375 
                 NM_006614.2 
                 204591_at 
                 8.685132271 
               
               
                 1119752 
                 BASPI 
                 30795230 
                 NM_006317.3 
                 202391_at 
                 8.663402838 
               
               
                 1131854 
                 GCLC 
                 45359851 
                 NM_001498.2 
                 202923_s_at 
                 −8.761521136 
               
               
                 1105801 
                 MAN2A1 
                 51477713 
                 NM_002372.2 
                 235103_at 
                 −8.828675125 
               
               
                 1097824 
                 MAP2 
                 87578393 
                 NM_001039538.1 
                 225540_at 
                 −9.345688564 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2390 
               
             
            
               
                   
               
               
                 MCL vs. splenic predictor genes 
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Gene 
                   
                 GENBANK 
                 Affymetrix probe 
                   
               
               
                 UNIQID 
                 symbol 
                 gi 
                 Accession 
                 set ID 
                 Scale Factor 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 1106855 
                 KIAA1909 
                 148529024 
                 NM_052909.3 
                 236255_at 
                 14.48278638 
               
               
                 1121739 
                 ZNF135 
                 34419632 
                 NM_003436.2 
                 206142_at 
                 11.95918572 
               
               
                 1111850 
                   
                 BC047698.1 
                 BC047698.1 
                 241808_at 
                 11.13464157 
               
               
                 1098024 
                 RSPRY1 
                 45387948 
                 NM_133368.1 
                 225774_at 
                 10.10869886 
               
               
                 1130764 
                 HNRNPA0 
                 52426775 
                 NM_006805.3 
                 201055_s_at 
                 10.06898534 
               
               
                 1135342 
                 SHOX2 
                 87044887 
                 NM_003030.3 
                 210135_s_at 
                 9.565884385 
               
               
                 1097218 
                 TCEAL8 
                 55749465 
                 NM_001006684.1 
                 224819_at 
                 9.187725705 
               
               
                 1117193 
                 ZBTB10 
                 157694498 
                 NM_001105539.1 
                 233899_x_at 
                 9.12522795 
               
               
                 1139564 
                 PSMD10 
                 28605122 
                 NM_002814.2 
                 219485_s_at 
                 9.066714773 
               
               
                 1132834 
                 SOX11 
                 30581115 
                 NM_003108.3 
                 204914_s_at 
                 8.908574745 
               
               
                 1131130 
                 MARCKS 
                 153070259 
                 NM_002356.5 
                 201670_s_at 
                 8.732921026 
               
               
                 1131756 
                 PDCD4 
                 34304340 
                 NM_014456.3 
                 202730_s_at 
                 8.441424593 
               
               
                 1102187 
                 PKHD1L1 
                 126116588 
                 NM_177531.4 
                 230673_at 
                 8.391861029 
               
               
                 1098195 
                 TMEM64 
                 116089278 
                 NM_001008495.2 
                 225974_at 
                 8.349839204 
               
               
                 1101211 
                 STRBP 
                 21361744 
                 NM_018387.2 
                 229513_at 
                 8.337208237 
               
               
                 1136673 
                 GNAS 
                 117938757 
                 NM_000516.4 
                 212273_x_at 
                 8.254076655 
               
               
                 1139116 
                 USP16 
                 50312663 
                 NM_001001992.1 
                 218386_x_at 
                 8.179384251 
               
               
                 1098694 
                 SBK1 
                 67906173 
                 NM_001024401.2 
                 226548_at 
                 7.935903681 
               
               
                 1120519 
                 WWP2 
                 40806206 
                 NM_007014.3 
                 204022_at 
                 −7.881202253 
               
               
                 1114916 
                 CPLX3 
                 75677370 
                 NM_001030005.2 
                 222927_s_at 
                 −8.33683119 
               
               
                   
               
            
           
         
       
     
     With so many candidate predictor genes being utilized, it is possible to generate a predictor model that accurately predicts every element of a training set but fails to perform on an independent sample. This occurs because the model incorporates and “learns” individual characteristics of each sample in the training set. Leave-one-out cross-validation was used to verify that the prediction models generated above would work on independent samples that the models had not encountered previously. In this cross-validation method, a single sample is removed from the training set, and the predictor is developed again using the remaining data. The resulting model is then used to predict the sample that was removed. This method is repeated with each individual sample taken out. Since no sample is predicted from a model that includes that sample, this method provides an unbiased estimate of predictor accuracy. 
     When the predictors developed above were evaluated by leave-one-out cross-validation, all but one of the 21 MCL samples were correctly identified as MCL and none of the 489 non-MCL samples were mistakenly identified as MCL. 
     Example 12 
     Identification of Lymphoma Samples as MCL Based on Bayesian Gene Expression Data from a Lymphochip Microarray 
     Lymphoma samples with morphology consistent with MCL were identified by pathological review. Since t(11; 14) translocation and cyclin D1 overexpression have been consistently associated with MCL, cyclin D1 mRNA levels were measured in each sample by quantitative RT-PCR. Of the 101 samples analyzed, 92 expressed cyclin D1 mRNA. These 92 samples, which were deemed the “core group” of MCLs, were divided into a training set and a validation set. Gene expression was measured in all 101 samples using a Lymphochip microarray (Alizadeh 1999). For comparison, gene expression was measure in 20 samples identified as SLL. In addition, MCL expression data was compared to expression data obtained previously for GCB (134 cases) and ABC (83 cases) (Rosenwald 2002). Several thousand genes were differentially expressed between cyclin D1-positive MCL and the other lymphoma types with high statistical significance (p&lt;0.001). A complete listing of these genes is available at Rosenwald et al.,  Cancer Cell,  3:185-197 (2003), which is referenced therein at page 194 and which is hosted by the Lymphoma/Leukemia Molecular Profiling Project Gateways at the National Institute of Health web site. 
     Three different binary predictor models were developed: MCL vs. SLL, MCL vs. GCB, and MCL vs. ABC. Each of these models was designed to calculate the probability that a sample was MCL rather than the other lymphoma type in the pair. For each pair, the genes that were most differentially expressed between MCL and the other lymphoma type in the pair were identified, and the difference in expression between the lymphoma types was quantified using a Student&#39;s t-test. An LPS was then calculated for each sample using the following formula: 
                 LPS   ⁡     (   X   )       =       ∑     j   ∈   G       ⁢       t   j     ⁢     X   j           ,         
where X j  is the expression of gene j in sample X and t j  is the t-statistic for the difference in expression of gene j between the two lymphoma types in the pair. Cyclin D1 was excluded from the calculation of LPS so that the model could be used to identify potential MCL cases that were cyclin D1 negative.
 
     After an LPS had been formulated for each lymphoma sample, the mean and standard deviation of these LPS&#39;s was calculated for each lymphoma type. For a new sample X, Bayes&#39; rule can be used to estimate the probability q that the sample belongs to MCL rather than the second lymphoma type in the pair using the following equation: 
               q   ⁡     (     X   ⁢           ⁢   is   ⁢           ⁢   MCL     )       =       ϕ   ⁡     (         LPS   ⁡     (   X   )       ;       μ   ^     MCL       ,       σ   ^     MCL       )           ϕ   ⁡     (         LPS   ⁡     (   X   )       ;       μ   ^     MCL       ,       σ   ^     MCL       )       +     ϕ   ⁡     (         LPS   ⁡     (   X   )       ;       μ   ^     2       ,       σ   ^     2       )                 
where φ(x; μ, σ) is the normal density function with mean μ and standard deviation σ, {circumflex over (μ)} MCL  and {circumflex over (σ)} MCL  are the sample mean and variance of the LPS values for MCL, and {circumflex over (μ)} 2  and {circumflex over (σ)} 2  are the sample mean and variance of the LPS values for the second lymphoma type of the pair. A cut-off point of 90% was selected for assigning a sample to a particular lymphoma type. Every sample in the training set were classified correctly using this model ( FIG. 16 ). When applied to the validation set, the model correctly classified 98% of the cyclin D1-positive MCL cases as MCL ( FIG. 16 ).
 
     This diagnostic test was applied to nine lymphoma cases that were morphologically consistent with MCL, but negative for cyclin D1 expression. Seven of these samples were classified as MCL, one was classified as GCB, and one was not assigned to any lymphoma type because none of the pairs generated a probability of 90% or greater. 
     Example 13 
     Classification of DLBCL Samples Based on Bayesian Analysis of Gene Expression Data from the Lymphochip Microarray 
     A statistical method to classify DLBCL samples based on Bayesian analysis was developed using gene expression data obtained using the Lymphochip cDNA microarray (Rosenwald 2002). This data is available at http://llmpp.nih.gov/DLBCL. The data was divided into two sets: a training set used to create and optimize the prediction model, and a validation set to evaluate the performance of the model. The training set consisted of 42 ABC DLBCL samples and 67 GCB DLBCL samples, while the validation set consisted of 41 ABC DLBCL samples, 67 GCB DLBCL samples, and 57 type 3 DLBCL samples (Shipp 2002). 
     Genes that were listed as present on &gt;50% of the samples were identified, and the signal value for these genes on each microarray was normalized to 1,000. After normalization, all signal values under 50 were set to 50. A log 2  transformation was then performed on all the signal values. 
     An LPS for distinguishing between two lymphoma types was calculated for each sample X in the training set using an equation: 
                 LPS   ⁡     (   X   )       =       ∑   j     ⁢       t   j     ⁢     X   j           ,         
where X j  represents the expression level of gene j and t j  is a scaling factor whose value depends on the difference in expression of gene j between the two lymphoma types. The scaling factor used in this example was the t-statistic generated by a t test of the difference in gene j expression between two lymphoma types. Only those genes with the largest t-statistics were included when calculating the LPS for each sample. The list of genes used to generate the LPS was narrowed further by including only those genes that were most variably expressed within the training set. Only genes in the top third with respect to variance were included. Genes that displayed a correlation with proliferation or lymph node signatures (Shaffer 2001; Rosenwald 2002) were eliminated from consideration, because these genes are often variably expressed within samples from a single lymphoma type (Rosenwald 2002).
 
     Since the LPS is a linear combination of gene expression values, its distribution within each lymphoma type should be approximately normal, provided that it includes a sufficient number of genes and the correlation structure of those genes is not extreme. The mean and variance of these normal distributions within a lymphoma type can then be estimated from the combined LPS&#39;s of all samples within the type. The LPS distribution of two lymphoma types can be used to estimate the probability that a new sample belongs to one of the types using Bayes&#39; rule. The probability q that a sample Y belongs to lymphoma type 1 can be determined by an equation: 
               q   ⁡     (     Y   ⁢           ⁢   is   ⁢           ⁢   subtype   ⁢           ⁢   1     )       =       ϕ   ⁡     (         LPS   ⁡     (   Y   )       ;       μ   ^     1       ,       σ   ^     1       )           ϕ   ⁡     (         LPS   ⁡     (   Y   )       ;       μ   ^     1       ,       σ   ^     1       )       +     ϕ   ⁡     (         LPS   ⁡     (   Y   )       ;       μ   ^     2       ,       σ   ^     2       )                 
where φ(x; μ, σ) is the normal density function with means μ and standard deviation φ, {circumflex over (μ)} 1  and {circumflex over (σ)} 1  are the sample mean and variance of the LPS values for lymphoma type 1, and {circumflex over (μ)} 2  and {circumflex over (σ)} 2  are the sample mean and variance of the LPS values for lymphoma type 2. This calculation was used to determine the probability that each sample in the training set belonged to GCB or ABC. A sample was classified as a particular type if it had a 90% or greater probability of belonging to that type. The number of genes in the predictor model was optimized based on the accuracy with which the predictor classified samples into the ABC or GCB subtypes defined previously by hierarchical clustering (Rosenwald 2002). The final predictor incorporated 27 genes, and correctly classified 87% of the training set samples into the subtype to which they had been assigned by hierarchical clustering ( FIG. 17 ). The genes included in the predictor are listed in Table 2391.
 
     
       
         
           
               
               
               
               
               
               
             
               
                 TABLE 2391 
               
               
                   
               
               
                   
                   
                 Gene 
                   
                 GENBANK 
                 Affymetrix probe 
               
               
                 UNIQID 
                 Unigene ID Build 167 
                 symbol 
                 gi 
                 Accession 
                 set ID 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 19375 
                 235860 
                 FOXP1 
                 60498986 
                 NM_001012505.1 
                 224837_at 
               
               
                 19346 
                 109150 
                 SH3BP5 
                 109134343 
                 NM_001018009.2 
                 201810_s_at 
               
               
                 19227 
                 193857 
                 LOC96597 
                 89041248 
                 XM_378655.2 
                 233483_at 
               
               
                 16049 
                 439852 
                 IGHM 
                 21757751 
                 AK097859.1 
               
               
                 32529 
                 55098 
                 CCDC50 
                 33186926 
                 NM_174908.2 
                 226713_at 
               
               
                 24729 
                 127686 
                 IRF4 
                 4505286 
                 NM_002460.1 
                 204562_at 
               
               
                 24899 
                 81170 
                 PIM1 
                 31543400 
                 NM_002648.2 
                 209193_at 
               
               
                 19348 
                 NA 
                 IGHM 
                 21757751 
                 AK097859.1 
               
               
                 27565 
                 444105 
                 ENTPD1 
                 147905699 
                 NM_001098175.1 
                 209474_s_at 
               
               
                 17227 
                 170359 
                 IL16 
                 148833502 
                 NM_004513.4 
                 209827_s_at 
               
               
                 26919 
                 118722 
                 FUT8 
                 30410721 
                 NM_004480.3 
                 203988_s_at 
               
               
                 24321 
                 171262 
                 ETV6 
                 153267458 
                 NM_001987.4 
                 217377_x_at 
               
               
                 29385 
                 167746 
                 BLNK 
                 40353774 
                 NM_013314.2 
                 207655_s_at 
               
               
                 16858 
                 376071 
                 CCND2 
                 16950656 
                 NM_001759.2 
                 200951_s_at 
               
               
                 31801 
                 386140 
                 BMF 
                 51558687 
                 NM_001003940.1 
                 226530_at 
               
               
                 19234 
                 418004 
                 PTPN1 
                 18104977 
                 NM_002827.2 
                 202716_at 
               
               
                 26385 
                 307734 
                 MME 
                 116256328 
                 NM_000902.3 
                 203434_s_at 
               
               
                 24361 
                 388737 
                   
                 76779240 
                 BC106050.1 
               
               
                 24570 
                 446198 
                 SAMD12 
                 156119596 
                 NM_001101676.1 
               
               
                 24904 
                 18166 
                 KIAA0870 
                 50345869 
                 NM_014957.2 
                 212975_at 
               
               
                 24429 
                 155024 
                 BCL6 
                 21040323 
                 NM_001706.2 
                 228758_at 
               
               
                 28224 
                 387222 
                 NEK6 
                 34147501 
                 NM_014397.3 
                 223158_s_at 
               
               
                 27673 
                 124922 
                 LRMP 
                 42789728 
                 NM_006152.2 
                 204674_at 
               
               
                 24376 
                 317970 
                 SERPINA11 
                 110225348 
                 NM_001042518.1 
               
               
                 17496 
                 300592 
                 MYBL1 
                 122937230 
                 NM_001080416.1 
                 213906_at 
               
               
                 17218 
                 283063 
                 LMO2 
                 6633806 
                 NM_005574.2 
                 204249_s_at 
               
               
                 28338 
                 78877 
                 ITPKB 
                 38569399 
                 NM_002221.2 
                 203723_at 
               
               
                   
               
            
           
         
       
     
     Since the samples used to estimate the distribution of the LPS&#39;s were the same samples used to generate the model, there was a possibility of overfitting. Overfitting would result in a model that indicates a larger separation between the LPS&#39;s of two lymphoma types than would be found in independent data. To ensure that overfitting was not taking place, the model was tested on the validation set. The reproducibility of the predictor model was verified by its ability to correctly classify 88% of the samples in the validation set ( FIG. 18 ). Interestingly, 56% of the DLBCL samples that had been placed in the type 3 subtype by hierarchical clustering were classified as either ABC or GCB using this Bayesian model. 
     In previous experiments, the genes that were used to distinguish GCB and ABC were deliberately selected to include those that were preferentially expressed in normal GC B cells (Alizadeh 2000; Rosenwald 2002). In the present analysis, the predictor model was not biased a priori to include such genes. The ABC and GCB lymphoma types as defined by the Bayesian model were analyzed for differential expression of GC B cell restricted genes. Thirty seven genes were found to be both more highly expressed in GC B cells than at other stages of differentiation (p&lt;0.001) and differentially expressed between DLBCL subtypes (p&lt;0.001) ( FIG. 19A ). These 37 genes are listed in Table 2392. 
                                     TABLE 2392                       UNIQID   Unigene ID Build 167   Gene symbol                                                        28014   300592   MYBL1           24376   317970   SERPINA11           24429   155024   BCL6           16886   124922   LRMP           27374   283063   LMO2           29912   446198           24510   266175   PAG           24854   439767   TOX           32171   307734   MME           24361   388737           19365   171857   Cyorf15a           27292   272251   KLHL5           24822   283794   PCDHGC3           30923   446195           24825   88556   HDAC1           31696   91139   SLC1A1           26976   434281   PTK2           19279   49614   GCET2           17866   1765   LCK           24386   437459   MYO1E           33013   293130   VNN2           25126           30498   157441   SPI1           26512   379414   MFHAS1           26582   153260   SH3KBP1           17840   132311   MAP2K1           26000   25155   NET1           24323   149342   AICDA           30922   435904   C21orf107           30641   79299   LHFPL2           19308   179608   DHRS9           24455   405387           30034   300208   SEC23IP           24977   169939   HS2ST1           24449   206097   RRAS2           30763   446198           27987   73792   CR2                        
All but two (AICDA and DHRS9) of these 37 genes were more highly expressed in GCB than in ABC. This demonstrates that the DLBCL subtypes defined by the Bayesian predictor seem to differ with respect to their cell of origin, with GCB retaining the gene expression program of normal GC B cells.
 
     ABC, on the other hand, displayed higher expression of genes characteristic of plasma cells ( FIG. 19B ). Twenty four genes were found to be both more highly expressed in plasma cells than in B cells at earlier developmental stages (p&lt;0.001) and differentially expressed between the DLBCL subtypes (p&lt;0.001). These 24 genes are listed in Table 2393. 
                             TABLE 2393               UNIQID   Unigene ID Build 167   Gene symbol                                            16614   127686   IRF4       26907   118722   FUT8       31104   313544   NS       19219   355724   CFLAR       26174   28707   SSR3       24566   169948   KCNA3       34500   442808   B4GALT2       26991   314828   UPP1       30191   438695   FKBP11       27402   259855   EEF2K       26096   434937   PPIB       15887   2128   DUSP5       32440   512686   C20orf59       34827   429975   PM5       29232   437638   XBP1       17763   76640   RGC32       32163   445862   RAB30       17814   5353   CASP10       31460   409223   SSR4       26693   83919   GCS1       25130   409563   PACAP       16436   267819   PPP1R2       31610   76901   PDIR       28961   212296   ITGA6                    
The majority of these plasma cell-restricted genes were more highly expressed in ABC than in GCB. Eight of the 32 genes encode proteins that reside and function in the endoplasmic reticulum (ER) or Golgi apparatus, suggesting that ABCs have increased the intracellular machinery for protein secretion. These eight genes are denoted in the above list by the designation “ER” or “golgi” in parentheses. Another gene on this list, XBP-1 transcription factor, encodes a protein that is required for plasma cell differentiation (Reimold 2001) and is involved in the response to unfolded proteins in the ER (Calfon 2002). ABC have not undergone full plasmacytic differentiation, however, because other key plasma cell genes such as Blimp-1 were not more highly expressed in ABC.
 
     Example 14 
     Classification of DLBCL Samples Based on Bayesian Analysis of Gene Expression Data from the Affymetrix HU6800 Microarray 
     The prediction method described in Example 13 above was applied to gene expression data from 58 DLBCL samples obtained using an Affymetrix HU 6800 oligonucleotide microarray (Shipp 2002). This data is available at www.genome.wi.mit.edu/MPR/lymphoma. The first step in analyzing this data was to exclude all microarray features with a median signal value of &lt;200 across the samples. Multiple microarray features representing the same gene were then averaged. Of the 27 genes in the DLBCL subtype predictor developed using the Lymphochip data (above), only 14 were represented on the Affymetrix array and passed this filtering process. These 14 genes are listed in Table 2394. 
                                         TABLE 2394                       Gene       GENBANK   Affymetrix probe       UNIQID   Unigene ID Build 167   symbol   gi   Accession   set ID                                                        24729   127686   IRF4   4505286   NM_002460.1   204562_at       17227   170359   IL16   148833502   NM_004513.4   209827_s_at       26907   118722   FUT8   30410721   NM_004480.3   203988_s_at       27565   444105   ENTPD1   147905699   NM_001098175.1   209474_s_at       16858   376071   CCND2   16950656   NM_001759.2   200951_s_at       24899   81170   PIM1   31543400   NM_002648.2   209193_at       16947   418004   PTPN1   18104977   NM_002827.2   202716_at       16049   439852   IGHM   21757751   AK097859.1       26385   307734   MME   116256328   NM_000902.3   203434_s_at       27673   124922   LRMP   42789728   NM_006152.2   204674_at       24429   155024   BCL6   21040323   NM_001706.2   228758_at       17218   283063   LMO2   6633806   NM_005574.2   204249_s_at       28338   78877   ITPKB   38569399   NM_002221.2   203723_at       17496   300592   MYBL1   122937230   NM_001080416.1   213906at                    
These 14 genes were used to create a new DLBCL subtype predictor in which the LPS scaling coefficients were again calculated based on the DLBCL subtype distinction in the Lymphochip data set (Rosenwald 2002). To account for systematic measuring differences between the Affymetrix and Lymphochip microarrays, the expression value of each gene on the Affymetrix microarray was shifted and scaled to match the mean and variance of the corresponding expression values on the Lymphochip. The adjusted expression values for each of the 14 genes were then used to calculate LPS&#39;s for each sample. DLBCL subtype membership was again assigned on a cut-off of 90% certainty. Several observations suggested that the predictor identified ABC and GCB samples within the Affymetrix data set that were comparable to those found in the Lymphochip data set. First, the relative proportions of ABC (29%) and GCB (53%) were very similar to the corresponding proportions in the Lymphochip data set (34% and 49%, respectively). Second, 43 genes were found to be differentially expressed between the two DLBCL subtypes with high significance (p&lt;0.001) in the Affymetrix data. This number is substantially higher than would be expected by chance, given that the Affymetrix microarray measures the expression of approximately 5,720 genes. The symbols for these 43 genes were: IGHM; TCF4; IRF4; CCND2; SLA; BATF; KIAA0171; PRKCB1; P2RX5; GOT2; SPIB; CSNK1E; PIM2; MARCKS; PIM1; TPM2; FUT8; CXCR4; SP140; BCL2; PTPN1; KIAA0084; HLA-DMB; ACP1; HLA-DQA1; RTVP1; VCL; RPL21; ITPKB; SLAM; KRT8; DCK; PLEK; SCA1; PSIP2; FAM3C; GPR18; HMG14; CSTB; SPINK2; LRMP; MYBL1; and LMO2. Third, the 43 genes differentially expressed between the types included 22 genes that were not used in the predictor but were represented on Lymphochip arrays. Fourteen of these 22 genes were differentially expressed on the Lymphochip array with high statistical significance (p&lt;0.001). Finally, the expression of the c-rel gene was previously found to correspond to amplification of the c-rel genomic locus in DLBCL tumor cells, and oncogenic event occurring in GCB but not ABC (Rosenwald 2002). In the Affymetrix data set, c-rel was differentially expressed between the two subtypes (p=0.0025), and was highly expressed only in a subset of GCB&#39;s.
 
     Example 15 
     Identification of DLBCL Samples as PMBL Based on Bayesian Analysis of Gene Expression Data from the Lymphochip Microarray 
     310 lymphoma biopsy samples identified as DLBCL by a panel of hematopathologists were divided into a 36 sample training set and a 274 sample validation set, with the validation set consisting of the DLBCL samples as classified previously in Example 13. All patients from whom the samples were derived had been treated with anthracycline-containing multiagent chemotherapy protocols, with some patients additionally receiving radiation therapy. The training set was profiled for gene expression using Lymphochip microarrays comprising 15, 133 cDNA elements as described previously (Alizadeh 2000). The data is available at the web site companion for Rosenwald et al.,  J. Exp. Med.,  198: 851-862 (2003), which is referenced therein at page 852 and which is hosted by Lymphoma/Leukemia Molecular Profiling Project Gateway at the National Institute of Health web site. The validation set had previously been profiled using Lymphochip microarrays comprising 12,196 cDNA elements (Rosenwald 2002). This data is available at the web site companion for Rosenwald et al.,  New Eng. J. Med.,  346: 1937-1947 (2002), which is referenced therein at page 1938 and which is hosted by the Lymphoma/Leukemia Molecular Profiling Project Gateway at the National Institute of Health web site. 
     A hierarchical clustering algorithm (Eisen 1998) was used to organize the genes by their expression patterns across the 36 samples in the training set. A large group of genes that were more highly expressed in lymphomas with mediastinal involvement than in other DLBCLs was shown to be tightly clustered in the resulting dendrogram ( FIG. 20A ). This cluster of genes included two genes, MAL and  FIG. 1 , previously shown to be highly expressed in PMBL (Copie-Bergman 2002; Copie-Bergman 2003). Several of the lymphomas with mediastinal involvement did not express this set of putative PMBL signature genes, and it was suspected that these samples were more likely to be conventional DLBCL than PMBL. Hierarchical clustering was used to organize the samples according to their expression of the PMBL signature genes, resulting in two major clusters of cases ( FIG. 20B ). One cluster contained 21 samples designated “PMBL core” samples by virtue of their higher expression of PMBL signature genes. The other cluster contained some samples that had virtually no expression of these genes, and other samples that did express these genes but at lower levels than the PMBL core samples. 
     A gene expression-based method for distinguishing PMBL core cases from GCB and ABC DLBCL cases based on Bayesian analysis was developed using the methods described in Examples 13 and 14. A set of genes were selected that were differentially expressed between the PMBL core samples and both GCB and ABC (p&lt;0.001). This set of genes included all of the PMBL signature genes identified by hierarchical clustering ( FIG. 20A ), as well as a large number of additional genes. Many of the genes in this set belonged to the lymph node gene expression signature (Alizadeh 2000; Rosenwald 2002). These genes were excluded from the final predictor because they might cause some DLBCL samples with higher expression of lymph node gene expression signature genes to be misclassified as PMBL. The list of PMBL distinction genes was refined by adding a requirement that they also be differentially expressed between the PMBL core samples and a subgroup of six DLBCL samples with higher expression of lymph node gene expression signature genes (p&lt;0.001). The resulting set of 46 genes included 35 genes that were more highly expressed in PMBL and 11 genes that were more highly expressed in DLBCL ( FIG. 21A ). The 46 genes in this set were PDL2, SNFT, IL13RA1, FGFR1, FLJ10420, CCL17/TARC, TNFRSF8/CD30, E2F2, MAL, TNFSF4/OX40 ligand, IL411/Fig1, IMAGE:686580, BST2, FLJ31131, FCER2/CD23, SAMSN1, JAK2, FLJ0066, MST1R, TRAF1, SLAM, LY75, TNFRSF6/Fas, FNBP1, TLR7, TNFRSF17/BCMA, CDKN1A/p21CIP1, RGS9, IMAGE:1340506, NFKB2, KIAA0339, ITGAM, IL23A, SPINT2, MEF2A, PFDN5, ZNF141, IMAGE:4154313, IMAGE:825382, DLEU1, ITGAE, SH3BP5, BANK, TCL1A, PRKAR1B, and CARD 11. A series of linear predictor scores were generated based on the expression of this gene set. Based on the distribution of linear predictor scores within a particular lymphoma type, Bayes&#39; rule can be used to estimate the probability that a particular sample belongs to either of the two types. An arbitrary probability cut-off of 90% or greater was used to classify a sample as a particular lymphoma type. All of the PMBL core samples were classified as PMBL using this method, as were six of the other lymphoma samples with mediastinal involvement. However, nine of the lymphoma samples with mediastinal involvement were classified as a DLBCL, as were all of the GCB and ABC samples. 
     In the validation set, 11 samples were identified on clinical grounds as being consistent with a diagnosis of PMBL, and the Bayesian model classified nine of these as PMBL ( FIG. 21B ). Interestingly, 12 of the remaining 263 DLBCL samples were classified as PMBL by the predictor.  FIG. 21B  shows that these cases were indistinguishable by gene expression from the nine cases diagnosed as PMBL on clinical grounds. As expected, the average expression of the PMBL predictor genes in the 249 samples classified as DLBCL was notably lower than in the 22 PMBL cases. Thus, PMBL represents a third subgroup of DLBCL than can be distinguished from ABC and GCB by gene expression profiling. 
     Table 2395 compares the clinical parameters of patients assigned to the PMBL, ABC, and GCB subgroups of DLBCL using this prediction method. 
                                                 TABLE 2395                       ABC   GCB   PMBL   PMBL   PMBL               DLBCL   DLBCL   Training set   Validation set   All cases   P value                                                                Median age   66   61   33   33   33   4.4E−16       Age &lt;35    5%   10%   52%   56%   53%   7.2E−14       Age 35-60   29%   38%   44%   28%   37%       Age &gt;60   66%   52%    4%   17%    9%       Gender = male   59%   53%   44%   50%   47%   0.38       Female &lt;35    2%    3%   32%   39%   35%   1.1E−12       Male &lt;35    2%    7%   20%   17%   19%       Female 35-60    6%   18%   24%    6%   16%       Male 35-60   23%   19%   20%   22%   21%       Female &gt;60   33%   25%    0%    6%    2%       Male &gt;60   34%   27%    4%   11%    7%                    
PMBL patients were significantly younger than other DLBCL patients, with a median age at diagnosis of 33 years compared with a median age of 66 and 61 years for ABC and GCB patients, respectively. Although there was no significant difference in gender distribution among the DLBCL subgroups, young women (&lt;35 years) accounted for 35% of PMBL patients, more than any other DLBCL subgroup. Young men (&lt;35 years) were also more frequently represented in the PMBL subgroup, accounting for 19% of the patients. Correspondingly, older men and women (age&gt;60) were significantly underrepresented in the PMBL subgroup. These clinical characteristics were observed in both the training set and the validation set of PMBL cases, demonstrating that the PMBL predictor reproducibly identified a clinically distinct subgroup of DLBCL patients.
 
     The PMBL subgroup defined by the PMBL predictor had a relatively favorable overall survival rate after therapy ( FIG. 22 ). PMBL patients had a five-year survival rate of 64%, superior to the 46% rate seen in DLBCL patients as a whole (p=0.0067). The survival of the PMBL subgroup was significantly better than the 30% five-year survival rate of the ABC subgroup ( FIG. 22 ; p=5.8E-5), but only marginally better than the 59% five-year survival rate of the GCB subgroup (p=0.18). 
     Example 16 
     Classification of Lymphomas into Types Based on Bayesian Analysis of Gene Expression Data from the Lymph Dx Microarray 
     Based on the clustering of the Lymph Dx microarray signals for the DLBCL samples, a cluster of “proliferation signature” genes and a cluster of “lymph node signature” genes were identified. The expression of these genes was averaged to form a proliferation signature and a lymph node signature. Each gene represented on the Lymph Dx microarray was placed into one of three “gene-list categories” based on its correlation with the proliferation or lymph node gene signatures. “Proliferation” genes were defined as those genes for which the correlation between their expression and the proliferation signature was greater than 0.35. Lymph node genes were defined as those genes for which the correlation between their expression and the lymph node signature was greater than 0.35. The remaining genes on the array were classified as standard genes. This classification resulted in 323 proliferation genes and 375 lymph node genes. 
     Two stages of lymphoma classification were performed using the gene expression data obtained for the above samples using the Lymph Dx microarray. The general procedure used to classify the samples is presented in flow chart form in  FIG. 1 . 
     For the first stage of expression analysis, the samples were divided into five types: FL, MCL, SLL, FH, and a class of aggressive lymphomas that included DLBCL and BL. Samples obtained from subjects with other diagnoses (e.g., MALT, LPC) were omitted from this analysis. Data from the Lymph Dx microarray was then used to compare gene expression in each possible lymphoma type pair (e.g., FH vs. FL, MCL vs. SLL, etc.). This resulted in the creation of ten “pair-wise models” (one for each possible lymphoma type pair) for predicting whether a sample fell into a particular lymphoma type. 
     For each lymphoma type pair, the difference in expression between the two types for every gene on the microarray was calculated, and a t-statistic was generated to represent this difference. Within each gene-list category (proliferation, lymph node, and standard), individual genes were ordered based on the absolute value of their t-statistic. Only those genes that displayed a statistically significant difference in expression between the two types were included in the model. Those genes with largest absolute t-statistics in each gene-list category were then used to generate a linear predictor score (LPS) for each sample. For a sample X and a set of genes G, the LPS was defined as: 
                 LPS   ⁡     (   X   )       =       ∑     j   ∈   G       ⁢       t   j     ⁢     X   j           ,         
where X j  is the expression of gene j in the sample and t j  is the t-statistic representing the difference in expression of gene j between the two lymphoma types. This formulation of LPS, known as the compound covariate predictor, has previously been used successfully (Radmacher 2002; Rosenwald 2003; Wright 2003). Other ways to formulate an LPS include Fisher linear discriminant analysis (Dudoit 2002), weighted voting (Golub 1999), linear support vector machines (Ramaswamy 2001), and nearest shrunken centroids (Tibshirani 2002).
 
     In order to optimize the number of genes used to generate the LPS, a series of LPS&#39;s were generated for each sample using between five and 100 genes from each gene-list category. The optimal number of genes is that number which generates a maximum t-statistic when comparing the LPS of two samples from different lymphoma types ( FIG. 23 ). This optimization procedure was repeated for every gene-list category in every pair-wise model, meaning that 30 optimizations were performed in all. 
     It was recognized that for some pair-wise models, it would be useful to calculate LPS&#39;s using different combinations of gene-list categories. LPS&#39;s were calculated for each sample using four different combinations. In the first, LPS was calculated using the standard genes only. In the second, LPS&#39;s were calculated for both the standard and proliferation genes, but not the lymph node genes. In the third, LPS&#39;s were calculated for both the standard and lymph node genes, but not the proliferation genes. In the fourth, LPS&#39;s were calculated using all three gene-list categories. 
     Depending on the number of gene-list categories included, between one and three LPS&#39;s were calculated for each sample in the pair-wise models. Thus, each sample could be thought of as a vector in a space of between one and three dimensions. Since the LPS&#39;s were sums of individual expressions, it was reasonable to approximate the distributions as normal. Multivariate normal distributions are defined by two quantities: a mean vector, which indicates the average value of each of the models within a given lymphoma type, and a covariance matrix, which indicates the magnitude and orientation spread of points away from this center. Both of these quantities can be estimated empirically from the observed data.  FIG. 24  shows the Standard and Proliferation LPS&#39;s for the FL vs. DLBCL/BL pair-wise model. The dotted lines indicate the standard deviations from the fitted multivariate normal distributions. 
     Once the multidimensional distributions have been estimated, Bayes&#39; rule (Bayes 1763) can be used to estimate the probability that a given sample belongs to one lymphoma type or another. Bayesian analysis of an LPS has been successfully employed in the past to distinguish DLBCL subtypes (Rosenwald 2003, Wright 2003). For a sample X, the probability q of the sample belonging to a first lymphoma type rather than a second lymphoma type can be calculated using the formula: 
             q   =       ϕ   ⁡     (         LPS   ⁡     (   X   )       ;       μ   ^     1       ,       σ   ^     1       )           ϕ   ⁡     (         LPS   ⁡     (   X   )       ;       μ   ^     1       ,       σ   ^     1       )       +     ϕ   ⁡     (         LPS   ⁡     (   X   )       ;       μ   ^     2       ,       σ   ^     2       )                 
where LPS(X) is the linear predictor score for sample X, φ(x; μ, σ) is the normal density function with mean μ and standard deviation σ, {circumflex over (μ)} 1  and {circumflex over (σ)} 1  are the mean and variance of the LPS&#39;s for the first lymphoma type, and {circumflex over (μ)} 2  and {circumflex over (σ)} 2  are the mean and variance of the LPS&#39;s for the second lymphoma type. Using this equation, a single probability q value can be developed for each sample and for each of the four LPS combinations. This q value can then be used to classify a sample as a first lymphoma type, a second lymphoma type, or unclassified. Samples with the highest q values are classified as the first lymphoma type, while samples with the lowest q values are classified as the second lymphoma type. Samples with middle range q values are deemed unclassified. Classifying the samples in this manner requires two cut-off points: a lower cut-off point between the second lymphoma type and unclassified, and an upper cut-off point between unclassified and the first lymphoma type. To develop these cut-off points, samples were ordered by their q values, and each possible cut-off point between adjacent samples was considered. To ensure that the cut-off points were reasonable, the lower cut-off point was restricted to between 0.01 and 0.5 and the upper cut-off point was restricted to between 0.5 and 0.99.
 
     Every cut-off point and model combination was analyzed by the following equation:
 
3.99*[(% of type 1 misidentified as type 2)+(% of type 2 misidentified as type 1)]+[(% of type 1 unclassified)+(% of type 2 misidentified)].
 
Using this equation, the cut-off point would be adjusted to allow an additional error only if this adjustment resulted in four or more unclassified samples becoming correctly classified. The final model and cut-off point for a given pair-wise analysis was that which minimized this equation. The equation utilizes percentages rather than the actual number of cases in order to account for the different number of samples in each class.
 
     All cut-off points between a given pair of adjacent q-values will produce the same division of data. Since cut-off point optimality is defined in terms of dividing the data into subtypes, all cut-off points between a pair of borderline cases will be equally optimal. In choosing where to place the actual cut-off point values, values were chosen that would lead to a larger unclassified region. When the lower cut-off point was being defined, a value would be chosen that was ⅕ of the way from the smallest borderline case to the largest. When the upper cut-off point was being defined, a value would be chosen that was ⅘ of the way from the smallest borderline case to the largest.  FIG. 25  illustrates the q-results of optimizing the cut-point for the FL versus DLBCL/BL samples. The optimal lower cut-off point for these samples was found at q=0.49, while the optimal upper cut-off point was found at q=0.84.  FIG. 26  indicates how this choice of cut-off points divided the space of LPS&#39;s. 
     The above procedures resulted in a series of pair-wise models for comparing every lymphoma type to every other lymphoma type. If there are n types, then there will be n−1 pair-wise models for each type. Since there were five lymphoma types in the stage 1 analysis, each type was involved in 4 pair-wise models. For instance, there were four different pair-wise models for MCL: MCL vs. FH, MCL vs. FL, MCL vs. SLL, and MCL vs. DLBCL/BL. For each sample tested, each pair-wise model will produce one of three possible results: 1) the sample belongs to the first lymphoma type of the pair-wise model, 2) the sample belongs to the second lymphoma type of the pair-wise model, or 3) the sample is unclassified. If each of the n−1 models agrees that the sample belongs to a particular lymphoma type, then the sample is designated as belonging to that type. If the n−1 models do not all agree that the sample belongs to a particular lymphoma type, the sample is designated as unclassified. 
     To ensure that the above methods did not result in overfitting (i.e., models that fit particular idiosyncrasies of the training set but fail when applied to independent data), the models were validated by leave-one-out cross-validation fashion (Hills 1966). Each sample was removed from the data one at a time, and a predictive model was developed as described above using the remaining data. This model was then used to predict the sample that was removed. Since the model being used to predict a given sample was generated from data that did not include that sample, this method provided an unbiased estimate of the accuracy of the model. 
     The results of the leave-one-out predictions are set forth in Tables 2396 and 2397, below. The rows in each table correspond to different sample groups, while the columns indicate the prediction results. The standard to which the prediction results were compared in this stage was the diagnoses of a panel of eight expert hematopathologists who used histological morphology and immunohistochemistry to classify the samples. Table 2396 provides classification results for the five lymphoma types tested (DLBCL/BL, FL, FH, MCL, SLL), while Table 2397 provides more specific results for classification of subtypes within these five lymphoma types. The results set forth in Table 2396 are also summarized in  FIG. 27 . 
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
             
               
                   
                 TABLE 2396 
               
               
                   
                   
               
               
                   
                 DLBCL/BL 
                 FL 
                 FH 
                 MCL 
                 SLL 
                 Unclassified 
                 Total 
                 % Correct 
                 % Unclassified 
                 % Error 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 DLBCL/BL 
                 249 
                 6 
                 0 
                 0 
                 0 
                 7 
                 262 
                 95% 
                 2% 
                 3% 
               
               
                 FL 
                 5 
                 154 
                 0 
                 0 
                 0 
                 14 
                 173 
                 89% 
                 8% 
                 3% 
               
               
                 FH 
                 0 
                 0 
                 17 
                 0 
                 0 
                 0 
                 17 
                 100% 
                 0% 
                 0% 
               
               
                 MCL 
                 0 
                 0 
                 0 
                 22 
                 0 
                 0 
                 22 
                 100% 
                 0% 
                 0% 
               
               
                 SLL 
                 0 
                 0 
                 0 
                 0 
                 14 
                 0 
                 14 
                 100% 
                 0% 
                 0% 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
               
               
               
               
               
               
               
               
               
               
             
               
                   
                 TABLE 2397 
               
               
                   
                   
               
               
                   
                 DLBCL/BL 
                 FL 
                 FH 
                 MCL 
                 SLL 
                 Unclassified 
                 Total 
                 % Correct 
                 % Unclassified 
                 % Error 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
               
            
               
                 ABC 
                 78 
                 0 
                 0 
                 0 
                 0 
                 0 
                 78 
                 100% 
                 0% 
                 0% 
               
               
                 GCB 
                 77 
                 4 
                 0 
                 0 
                 0 
                 4 
                 85 
                 91% 
                 5% 
                 5% 
               
               
                 PMBL 
                 33 
                 0 
                 0 
                 0 
                 0 
                 0 
                 33 
                 100% 
                 0% 
                 0% 
               
               
                 Unclassified 
                 27 
                 1 
                 0 
                 0 
                 0 
                 2 
                 30 
                 90% 
                 7% 
                 3% 
               
               
                 DLBCL 
               
               
                 DLBCL (not yet 
                 14 
                 0 
                 0 
                 0 
                 0 
                 1 
                 15 
                 93% 
                 7% 
                 0% 
               
               
                 subclassed) 
               
               
                 BL 
                 20 
                 1 
                 0 
                 0 
                 0 
                 0 
                 21 
                 95% 
                 0% 
                 5% 
               
               
                 FL grade 1 
                 1 
                 78 
                 0 
                 0 
                 0 
                 3 
                 82 
                 95% 
                 4% 
                 1% 
               
               
                 FL grade 2 
                 2 
                 58 
                 0 
                 0 
                 0 
                 3 
                 63 
                 92% 
                 5% 
                 3% 
               
               
                 FL grade 3A 
                 2 
                 18 
                 0 
                 0 
                 0 
                 8 
                 28 
                 64% 
                 29% 
                 7% 
               
               
                 Combined FL 
                 5 
                 154 
                 0 
                 0 
                 0 
                 14 
                 173 
                 89% 
                 8% 
                 3% 
               
               
                 grades 1, 2, 3A 
               
               
                 FL grade 3B 
                 2 
                 1 
                 0 
                 0 
                 0 
                 4 
                 7 
                 14% 
                 57% 
                 29% 
               
               
                 FL unknown grade 
                 3 
                 11 
                 0 
                 0 
                 0 
                 0 
                 14 
                 79% 
                 0% 
                 21% 
               
               
                 FH 
                 0 
                 0 
                 17 
                 0 
                 0 
                 0 
                 17 
                 100% 
                 0% 
                 0% 
               
               
                 MCL 
                 0 
                 0 
                 0 
                 22 
                 0 
                 0 
                 22 
                 100% 
                 0% 
                 0% 
               
               
                 SLL 
                 0 
                 0 
                 0 
                 0 
                 14 
                 0 
                 14 
                 100% 
                 0% 
                 0% 
               
               
                   
               
            
           
         
       
     
     As seen in Table 2396, perfect prediction of SLL, MCL, and FH samples was obtained. The success rate for predicting FL and the aggressive lymphomas (DLBCL/BL) was also very good, with only 3% of the samples being classified incorrectly. As seen in Table 2397, perfect prediction was also obtained for ABC and PMBL samples within the DLBCL samples. 
     Example 17 
     Classification of DLBCL/BL Samples into Subtypes Based on Bayesian Analysis of Gene Expression Data from the Lymph Dx Microarray 
     Samples identified as DLBCL/BL in Example 16 were subdivided into four types: ABC, GCB, PMBL, and BL. These samples were then used to generate six pair-wise models using the same procedure described in Example 16. The results of the leave-one-out predictions using these pair-wise models are set forth in Table 2398, below. These results are also summarized in  FIG. 28 . The rows in the table correspond to different sample groups, while the columns indicate the prediction results. In this stage, the ability of the prediction method to identify BL was again measured against the diagnoses of hematopathologists. The ability of the prediction method to identify the various DLBCL subtypes, on the other hand, was measured against previous studies in which this distinction between subtypes was based on gene expression data from a Lymphochip microarray (Alizadeh 2000, Rosenwald 2002, Rosenwald 2003, Wright 2003). 
     
       
         
           
               
               
               
               
               
               
               
               
               
               
             
               
                   
                 TABLE 2398 
               
               
                   
                   
               
               
                   
                 ABC 
                 GCB 
                 PMBL 
                 BL 
                 Unclassified 
                 Total 
                 % Correct 
                 % Unclassified 
                 % Error 
               
               
                   
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
               
               
               
               
            
               
                 ABC 
                 76 
                 0 
                 0 
                 0 
                 2 
                 78 
                 97% 
                 3% 
                 0% 
               
               
                 GCB 
                 1 
                 66 
                 2 
                 4 
                 4 
                 77 
                 86% 
                 9% 
                 5% 
               
               
                 PMBL 
                 0 
                 2 
                 27 
                 0 
                 4 
                 33 
                 82% 
                 12% 
                 6% 
               
               
                 Unclassified DLBCL 
                 5 
                 9 
                 1 
                 1 
                 11 
                 27 
                 NA 
                 41% 
                 4% 
               
               
                 DLBCL (not yet 
                 5 
                 5 
                 0 
                 1 
                 3 
                 14 
                 NA 
                 21% 
                 7% 
               
               
                 subclassed) 
               
               
                 BL 
                 0 
                 1 
                 0 
                 18 
                 1 
                 20 
                 90% 
                 5% 
                 5% 
               
               
                 FL grade 1 
                 0 
                 1 
                 0 
                 0 
                 0 
                 1 
               
               
                 FL grade 2 
                 0 
                 1 
                 0 
                 0 
                 1 
                 2 
               
               
                 FL grade 3A 
                 0 
                 2 
                 0 
                 0 
                 0 
                 2 
               
               
                 Combined FL grades 1, 2, 
                 0 
                 4 
                 0 
                 0 
                 1 
                 5 
               
               
                 3A 
               
               
                 FL grade 3B 
                 0 
                 1 
                 0 
                 0 
                 1 
                 2 
               
               
                 FL unknown grade 
                 0 
                 1 
                 0 
                 1 
                 1 
                 3 
               
               
                   
               
            
           
         
       
     
     As seen in Table 2398, only 1 of the 20 BL lymphoma samples was classified incorrectly. The classification of DLBCL into subtypes was also quite effective. All previously identified ABC subtype samples were again assigned to the ABC subtype, while only 5% of the GCB samples and 6% of the PMBL samples were assigned to a different subtype than they were assigned to previously. 
     The above classification was implemented using S+ software and the S+ subtype predictor script contained in the file entitled “Subtype_Predictor.txt,” located in the computer program listing appendix contained on CD number 22 of 22. This S+ script implements the lymphoma prediction algorithm. When this script is pasted into an S+ script window and run in a working directory containing the data set files discussed below, it will produce a text file entitled “PredictionResults.txt,” which indicates the results of the predictive algorithm. The other files in the computer program listing appendix contain the required data sets, in their required format, for carrying out the lymphoma type identification described above. The file entitled “GeneData.txt” contains the gene expression values for each sample analyzed. This file is included in the working directory when the S+ subtype predictor script is run. The file entitled “GeneID.txt” contains information about the genes in the GeneData.txt file, and is also included in the working directory when the S+ subtype predictor script is run. This file indicates the UNIQID for each gene, as well as the extent to which the gene is associated with the lymph node and proliferation signatures (“LN.cor” and “pro.cor,” respectively). The file entitled “SampleID.txt” contains information about the samples included in the “GeneData.txt” file, specifically the original classification of all the samples. This file is also included in the working directory when the S+ subtype predictor script is run. The file entitled “PredictionResults.txt” is an example of the productive output of the prediction algorithm. 
     After the above model was validated using leave-one-out cross-validation, the model was re-fit using all of the data to generate a final predictor that could be applied to a new set of data. Tables 2399-2414 indicate for each of the pair wise models the list of genes used, the weight given to each of those genes, the signature with which each gene was associated, the mean values and covariance matrices associated with the subtypes being compared, and the q-value cut-points of the pair-wise model. 
     
       
         
           
               
             
               
                 TABLE 2399 
               
               
                   
               
               
                 ABC vs. BL 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                   
                   
                   
                 Gene 
               
               
                 Signature 
                 Scale 
                 UNIQID 
                 Unigene ID Build 167 
                 Probe set 
                 symbol 
               
               
                   
               
               
                 Standard 
                 −18.87 
                 1101149 
                 517226 
                 229437_at 
                 BIC 
               
               
                 Standard 
                 −17.4 
                 1121452 
                 227817 
                 205681_at 
                 BCL2A1 
               
               
                 Standard 
                 −16.42 
                 1123163 
                 421342 
                 208991_at 
                 STAT3 
               
               
                 Standard 
                 −16.2 
                 1121629 
                 41691 
                 205965_at 
                 BATF 
               
               
                 Standard 
                 −15 
                 1134095 
                 89555 
                 208018_s_at 
                 HCK 
               
               
                 Standard 
                 −14.75 
                 1132636 
                 306278 
                 204490_s_at 
                 CD44 
               
               
                 Standard 
                 −14.33 
                 1119939 
                 170087 
                 202820_at 
                 AHR 
               
               
                 Standard 
                 −14.25 
                 1100138 
                 278391 
                 228234_at 
                 TIRP 
               
               
                 Standard 
                 −14.02 
                 1128626 
                 501452 
                 219424_at 
                 EB13 
               
               
                 Standard 
                 −13.89 
                 1132883 
                 432453 
                 205027_s_at 
                 MAP3K8 
               
               
                 Standard 
                 −13.88 
                 1134991 
                 444105 
                 209474_s_at 
                 ENTPD1 
               
               
                 Standard 
                 −13.37 
                 1109913 
                 355724 
                 239629_at 
                 CFLAR 
               
               
                 Standard 
                 −13.25 
                 1120389 
                 75367 
                 203761_at 
                 SLA 
               
               
                 Standard 
                 −12.99 
                 1131497 
                 114931 
                 202295_s_at 
                 CTSH 
               
               
                 Standard 
                 −12.71 
                 1115071 
                 390476 
                 223218_s_at 
                 MAIL 
               
               
                 Standard 
                 −12.46 
                 1136329 
                 132739 
                 211675_s_at 
                 HIC 
               
               
                 Standard 
                 −12.41 
                 1128195 
                 115325 
                 218699_at 
                 RAB7L1 
               
               
                 Standard 
                 −12.37 
                 1124381 
                 440808 
                 212288_at 
                 FNBP1 
               
               
                 Standard 
                 −12.30 
                 1100562 
                 26608 
                 228737_at 
                 C20orf100 
               
               
                 Standard 
                 −12.24 
                 1101272 
                 179089 
                 229584_at 
                 DKFZp434 
               
               
                 Standard 
                 −12.18 
                 1128536 
                 21126 
                 219279_at 
                 DOCK10 
               
               
                 Standard 
                 −11.64 
                 1098271 
                 300670 
                 226056_at 
                 CDGAP 
               
               
                 Standard 
                 −11.41 
                 1119566 
                 433506 
                 201954_at 
                 ARPC1B 
               
               
                 Standard 
                 −11.11 
                 1120651 
                 80205 
                 204269_at 
                 PIM2 
               
               
                 Standard 
                 −10.89 
                 1098952 
                 62264 
                 226841_at 
                 KIAA0937 
               
               
                 Standard 
                 −10.80 
                 1099939 
                 488173 
                 227983_at 
                 MGC7036 
               
               
                 Standard 
                 −10.67 
                 1134270 
                 352119 
                 208284_x_at 
                 GGT1 
               
               
                 Standard 
                 −10.44 
                 1134145 
                 4750 
                 208091_s_at 
                 DKFZP564 
               
               
                 Standard 
                 −10.39 
                 1123437 
                 73090 
                 209636_at 
                 NFKB2 
               
               
                 Standard 
                 −10.17 
                 1119884 
                 418004 
                 202716_at 
                 PTPM1 
               
               
                 Standard 
                 −10.14 
                 1129269 
                 62919 
                 220358_at 
                 SNFT 
               
               
                 Standard 
                 −10.13 
                 1126293 
                 504816 
                 215346_at 
                 TNFRSF5 
               
               
                 Standard 
                 −10.12 
                 1112344 
                 163242 
                 242406_at 
               
               
                 Standard 
                 −10.10 
                 1135550 
                 221811 
                 210550_s_at 
                 RASGRF1 
               
               
                 Standard 
                 −10.08 
                 1135165 
                 170359 
                 209827_s_at 
                 IL16 
               
               
                 Standard 
                 −10.05 
                 1120808 
                 127686 
                 204562_at 
                 IRF4 
               
               
                 Standard 
                 −10.01 
                 1122087 
                 72927 
                 206693_at 
                 IL7 
               
               
                 Standard 
                 −9.97 
                 1132004 
                 415117 
                 203217_s_at 
                 SIAT9 
               
               
                 Standard 
                 −9.88 
                 1114824 
                 193370 
                 222762_x_at 
                 LIMD1 
               
               
                 Standard 
                 −9.87 
                 1132034 
                 410455 
                 203271_s_at 
                 UNC119 
               
               
                 Standard 
                 −9.87 
                 1099680 
                 210387 
                 227677_at 
                 JAK3 
               
               
                 Standard 
                 −9.86 
                 1132830 
                 31210 
                 204908_s_at 
                 BCL3 
               
               
                 Standard 
                 −9.79 
                 1099631 
                 367639 
                 227624_at 
                 FLJ20032 
               
               
                 Standard 
                 −9.78 
                 1120267 
                 256278 
                 203508_at 
                 TNFRSF1B 
               
               
                 Standard 
                 −9.77 
                 1124187 
                 378738 
                 211986_at 
                 MGC5395 
               
               
                 Standard 
                 −9.73 
                 1108970 
                 140489 
                 238604_at 
               
               
                 Standard 
                 −9.71 
                 1136216 
                 512152 
                 211528_x_at 
                 HLA-G 
               
               
                 Standard 
                 −9.71 
                 1120993 
                 327 
                 204912_at 
                 IL10RA 
               
               
                 Standard 
                 −9.68 
                 1100847 
                 97411 
                 229070_at 
                 C6orf105 
               
               
                 Standard 
                 −9.64 
                 1123413 
                 418291 
                 209575_at 
                 IL10RB 
               
               
                 Standard 
                 −9.62 
                 1115704 
                 350268 
                 224569_s_at 
                 IRF2BP2 
               
               
                 Standard 
                 −9.58 
                 1108237 
                 126232 
                 237753_at 
               
               
                 Standard 
                 −9.55 
                 1121695 
                 511759 
                 206082_at 
                 HCP5 
               
               
                 Standard 
                 −9.48 
                 1101905 
                 170843 
                 230345_at 
               
               
                 Standard 
                 −9.42 
                 1119243 
                 440165 
                 201171_at 
                 ATP6V0E 
               
               
                 Standard 
                 −9.39 
                 1140457 
                 210546 
                 221658_s_at 
                 IL21R 
               
               
                 Standard 
                 −9.32 
                 1098506 
                 193400 
                 226333_at 
                 IL6R 
               
               
                 Standard 
                 −9.31 
                 1139805 
                 414362 
                 220230_s_at 
                 CYB5R2 
               
               
                 Standard 
                 −9.30 
                 1139037 
                 173380 
                 218223_s_at 
                 CKIP-1 
               
               
                 Standard 
                 −9.28 
                 1130533 
                 76507 
                 200706_s_at 
                 LITAF 
               
               
                 Standard 
                 −9.15 
                 1098678 
                 386140 
                 226530_at 
                 BMF 
               
               
                 Standard 
                 −9.04 
                 1133210 
                 434374 
                 205842_s_at 
                 JAK2 
               
               
                 Standard 
                 9.05 
                 1116432 
                 409362 
                 229356_x_at 
                 KIAA1259 
               
               
                 Standard 
                 9.17 
                 1097281 
                 7037 
                 224892_at 
                 PLDN 
               
               
                 Standard 
                 9.17 
                 1140018 
                 438482 
                 220917_s_at 
                 PWDMP 
               
               
                 Standard 
                 9.30 
                 1119997 
                 367811 
                 202951_at 
                 STK38 
               
               
                 Standard 
                 9.41 
                 1119817 
                 409194 
                 202561_at 
                 TNKS 
               
               
                 Standard 
                 9.55 
                 1139842 
                 133523 
                 220367_s_at 
                 SAP130 
               
               
                 Standard 
                 9.64 
                 1132122 
                 307734 
                 203434_s_at 
                 MME 
               
               
                 Standard 
                 9.77 
                 1119258 
                 88556 
                 201209_at 
                 HDAC1 
               
               
                 Standard 
                 9.80 
                 1128248 
                 234149 
                 218802_at 
                 FLJ20647 
               
               
                 Standard 
                 10.38 
                 1101211 
                 287659 
                 229513_at 
                 STRBP 
               
               
                 Standard 
                 10.52 
                 1123419 
                 170195 
                 209590_at 
                 BMP7 
               
               
                 Standard 
                 10.71 
                 1133755 
                 404501 
                 207318_s_at 
                 CDC2L5 
               
               
                 Standard 
                 10.80 
                 1128192 
                 102506 
                 218696_at 
                 EIF2AK3 
               
               
                 Standard 
                 10.85 
                 1124786 
                 22370 
                 212847_at 
                 NEXN 
               
               
                 Standard 
                 10.92 
                 1130114 
                 445084 
                 221965_at 
                 MPHOSPH9 
               
               
                 Standard 
                 11.00 
                 1126081 
                 309763 
                 215030_at 
                 GRSF1 
               
               
                 Standard 
                 11.17 
                 1118736 
                 96731 
                 38340_at 
                 HIP1R 
               
               
                 Standard 
                 11.26 
                 1124613 
                 296720 
                 212599_at 
                 AUTS2 
               
               
                 Standard 
                 11.43 
                 1125456 
                 300592 
                 213906_at 
                 MYBL1 
               
               
                 Standard 
                 11.60 
                 1097177 
                 9691 
                 224761_at 
                 GNA13 
               
               
                 Standard 
                 12.11 
                 1120400 
                 152207 
                 203787_at 
                 SSBP2 
               
               
                 Standard 
                 12.12 
                 1139266 
                 76640 
                 218723_s_at 
                 RGC32 
               
               
                 Standard 
                 12.22 
                 1100770 
                 65578 
                 228976_at 
               
               
                 Standard 
                 12.73 
                 1131246 
                 153752 
                 201853_s_at 
                 CDC25B 
               
               
                 Standard 
                 13.48 
                 1096503 
                 21379 
                 223522_at 
                 C9orf45 
               
               
                 Standard 
                 14.50 
                 1124920 
                 6150 
                 213039_at 
                 ARHGEF1 
               
               
                 Standard 
                 15.03 
                 1128360 
                 445043 
                 218988_at 
                 SLC35E3 
               
               
                 Standard 
                 15.24 
                 1099444 
                 434489 
                 227407_at 
                 FLJ90013 
               
               
                 Standard 
                 21.03 
                 1134582 
                 78202 
                 208794_s_at 
                 SMARCA4 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                 Standard 
               
               
                   
                   
               
               
                   
                 Mean ABC 
                 −4179.76 
                 Cut 1 
                 0.20 
               
               
                   
                 Mean BL 
                 −1894.68 
                 Cut 2 
                 0.80 
               
               
                   
                 Covariance ABC 
                 53707.58 
               
               
                   
                 Covariance BL 
                 194887.5 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2400 
               
               
                   
               
               
                 ABC vs. GCB 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Signature 
                 Scale 
                 UNIQID 
                 Unigene ID Build 167 
                 Probe set 
                 Gene symbol 
               
               
                   
               
               
                 Standard 
                 −15.31 
                 1122645 
                 158341 
                 207641_at 
                 TNFRSF13B 
               
               
                 Standard 
                 −14.56 
                 1120651 
                 80205 
                 204269_at 
                 PIM2 
               
               
                 Standard 
                 −14.18 
                 1120808 
                 127686 
                 204562_at 
                 IRF4 
               
               
                 Standard 
                 −13.84 
                 1114824 
                 193370 
                 222762_x_at 
                 LIMD1 
               
               
                 Standard 
                 −13.44 
                 1136687 
                 59943 
                 212345_s_at 
                 CREB3L2 
               
               
                 Standard 
                 −13.12 
                 1139805 
                 414362 
                 220230_s_at 
                 CYB5R2 
               
               
                 Standard 
                 −12.23 
                 1104552 
                 193857 
                 233483_at 
                 LOC96597 
               
               
                 Standard 
                 −12.19 
                 1097236 
                 235860 
                 224837_at 
                 FOXP1 
               
               
                 Standard 
                 −12.06 
                 1121629 
                 41691 
                 205965_at 
                 BATF 
               
               
                 Standard 
                 −11.93 
                 1128195 
                 115325 
                 218699_at 
                 RAB7L1 
               
               
                 Standard 
                 −11.72 
                 1111503 
                 502910 
                 241383_at 
                 KBRAS2 
               
               
                 Standard 
                 −11.66 
                 1134991 
                 444105 
                 209474_s_at 
                 ENTPD1 
               
               
                 Standard 
                 −11.27 
                 1098678 
                 386140 
                 226530_at 
                 BMF 
               
               
                 Standard 
                 −10.9 
                 1131074 
                 76894 
                 201572_x_at 
                 DCTD 
               
               
                 Standard 
                 −10.82 
                 1135165 
                 170359 
                 209827_s_at 
                 IL16 
               
               
                 Standard 
                 −10.7 
                 1132396 
                 118722 
                 203988_s_at 
                 FUT8 
               
               
                 Standard 
                 −10.54 
                 1131541 
                 310230 
                 202369_s_at 
                 TRAM2 
               
               
                 Standard 
                 −10.47 
                 1105759 
                 171262 
                 235056_at 
                 ETV6 
               
               
                 Standard 
                 −10.38 
                 1121564 
                 437783 
                 205865_at 
                 ARID3A 
               
               
                 Standard 
                 −10.16 
                 1130472 
                 192374 
                 200599_s_at 
                 TRA1 
               
               
                 Standard 
                 −10.04 
                 1132058 
                 161999 
                 203313_s_at 
                 TGIF 
               
               
                 Standard 
                 −10.03 
                 1105684 
                 195155 
                 234973_at 
                 SLC38A5 
               
               
                 Standard 
                 −9.95 
                 1097735 
                 26765 
                 225436_at 
                 LOC58489 
               
               
                 Standard 
                 −9.94 
                 1115071 
                 390476 
                 223218_s_at 
                 MAIL 
               
               
                 Standard 
                 −9.85 
                 1101149 
                 517226 
                 229437_at 
                 BIC 
               
               
                 Standard 
                 −9.83 
                 1119884 
                 418004 
                 202716_at 
                 PTPN1 
               
               
                 Standard 
                 −9.71 
                 1134095 
                 89555 
                 208018_s_at 
                 HCK 
               
               
                 Standard 
                 −9.68 
                 1135550 
                 221811 
                 210550_s_at 
                 RASGRF1 
               
               
                 Standard 
                 −9.61 
                 1098927 
                 356216 
                 226811_at 
                 FLJ20202 
               
               
                 Standard 
                 −9.6 
                 1120389 
                 75367 
                 203761_at 
                 SLA 
               
               
                 Standard 
                 −9.58 
                 1133910 
                 167746 
                 207655_s_at 
                 BLNK 
               
               
                 Standard 
                 9.56 
                 1118736 
                 96731 
                 38340_at 
                 HIP1R 
               
               
                 Standard 
                 9.58 
                 1128860 
                 323634 
                 219753_at 
                 STAG3 
               
               
                 Standard 
                 9.68 
                 1134582 
                 78202 
                 208794_s_at 
                 SMARCA4 
               
               
                 Standard 
                 9.7 
                 1121853 
                 98243 
                 206310_at 
                 SPINK2 
               
               
                 Standard 
                 10.14 
                 1119258 
                 88556 
                 201209_at 
                 HDAC1 
               
               
                 Standard 
                 10.19 
                 1132122 
                 307734 
                 203434_s_at 
                 MME 
               
               
                 Standard 
                 10.23 
                 1120400 
                 152207 
                 203787_at 
                 SSBP2 
               
               
                 Standard 
                 10.48 
                 1529344 
                 317970 
                 Lymph_Dx_065_at 
                 SERPINA11 
               
               
                 Standard 
                 10.64 
                 1124613 
                 296720 
                 212599_at 
                 AUTS2 
               
               
                 Standard 
                 10.72 
                 1132159 
                 147868 
                 203521_s_at 
                 ZNF318 
               
               
                 Standard 
                 10.98 
                 1097901 
                 266175 
                 225626_at 
                 PAG 
               
               
                 Standard 
                 11.1 
                 1128287 
                 300063 
                 218862_at 
                 ASB13 
               
               
                 Standard 
                 12.26 
                 1099686 
                 117721 
                 227684_at 
               
               
                 Standard 
                 12.45 
                 1112674 
                 310320 
                 242794_at 
                 MAML3 
               
               
                 Standard 
                 13.15 
                 1120370 
                 78877 
                 203723_at 
                 ITPKB 
               
               
                 Standard 
                 14.23 
                 1125456 
                 300592 
                 213906_at 
                 MYBL1 
               
               
                 Lymph Node 
                 6.8 
                 1097202 
                 386779 
                 224796_at 
                 DDEF1 
               
               
                 Lymph Node 
                 6.85 
                 1131755 
                 241257 
                 202729_s_at 
                 LTBP1 
               
               
                 Lymph Node 
                 7.27 
                 1136273 
                 13775 
                 211597_s_at 
                 HOP 
               
               
                 Lymph Node 
                 7.35 
                 1119424 
                 75485 
                 201599_at 
                 OAT 
               
               
                 Lymph Node 
                 7.86 
                 1095985 
                 83883 
                 222450_at 
                 TMEPAI 
               
               
                 Lymph Node 
                 8.02 
                 1124875 
                 18166 
                 212975_at 
                 KIAA0870 
               
               
                 Lymph Node 
                 8.32 
                 1124655 
                 79299 
                 212658_at 
                 LHFPL2 
               
               
                 Lymph Node 
                 8.62 
                 1115034 
                 387222 
                 223158_s_at 
                 NEK6 
               
               
                 Proliferation 
                 −9.11 
                 1120583 
                 153768 
                 204133_at 
                 RNU3IP2 
               
               
                 Proliferation 
                 −7.87 
                 1135492 
                 408615 
                 210448_s_at 
                 P2RX5 
               
               
                 Proliferation 
                 −7.68 
                 1127756 
                 313544 
                 217850_at 
                 NS 
               
               
                 Proliferation 
                 −7.57 
                 1097195 
                 149931 
                 224785_at 
                 MGC29814 
               
               
                 Proliferation 
                 −7.31 
                 1127813 
                 14317 
                 217962_at 
                 NOLA3 
               
               
                 Proliferation 
                 −7.24 
                 1138944 
                 84753 
                 218051_s_at 
                 FLJ12442 
               
               
                 Proliferation 
                 −6.99 
                 1139226 
                 266514 
                 218633_x_at 
                 FLJ11342 
               
               
                 Proliferation 
                 −6.7 
                 1137486 
                 441069 
                 214442_s_at 
                 MIZ1 
               
               
                 Proliferation 
                 −6.51 
                 1133786 
                 153591 
                 207396_s_at 
                 ALG3 
               
               
                 Proliferation 
                 −6.45 
                 1131150 
                 75514 
                 201695_s_at 
                 NP 
               
               
                 Proliferation 
                 −6.45 
                 1119076 
                 268849 
                 200681_at 
                 GLO1 
               
               
                 Proliferation 
                 −6.38 
                 1115679 
                 8345 
                 224523_s_at 
                 MGC4308 
               
               
                 Proliferation 
                 −6.34 
                 1110223 
                 212709 
                 239973_at 
               
               
                 Proliferation 
                 −6.3 
                 1529338 
                 284275 
                 Lymph_Dx_058_s_at 
                 PAK2 
               
               
                 Proliferation 
                 −6.24 
                 1135164 
                 458360 
                 209825_s_at 
                 UMPK 
               
               
                 Proliferation 
                 −6.24 
                 1128738 
                 335550 
                 219581_at 
                 MGC2776 
               
               
                 Proliferation 
                 −6.01 
                 1099088 
                 14355 
                 226996_at 
               
               
                 Proliferation 
                 −5.98 
                 1123192 
                 315177 
                 209100_at 
                 IFRD2 
               
               
                 Proliferation 
                 −5.83 
                 1116073 
                 146161 
                 227103_s_at 
                 MGC2408 
               
               
                 Proliferation 
                 5.79 
                 1097388 
                 278839 
                 225024_at 
                 C20orf77 
               
               
                 Proliferation 
                 6.13 
                 1124563 
                 249441 
                 212533_at 
                 WEE1 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                 Standard 
                 Lymph Node 
                 Proliferation 
               
               
                   
                   
               
               
                   
                 Mean ABC 
                 −2226.57 
                 476.67 
                 −1096.34 
                 Cut 1 
                 0.50 
               
               
                   
                 Mean GCB 
                 −1352.02 
                 547.18 
                 −1005.72 
                 Cut 2 
                 0.74 
               
               
                   
                 Covariance ABC 
                 33472.10 
                 3418.91 
                 4347.99 
               
               
                   
                   
                 3418.91 
                 1296.05 
                 846.32 
               
               
                   
                   
                 4347.99 
                 846.32 
                 1609.13 
               
               
                   
                 Covariance GCB 
                 53751.59 
                 466.34 
                 751.08 
               
               
                   
                   
                 466.34 
                 777.74 
                 249.29 
               
               
                   
                   
                 751.08 
                 249.29 
                 1708.67 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2401 
               
               
                   
               
               
                 ABC vs. PMBL 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Signature 
                 Scale 
                 UNIQID 
                 Unigene ID Build 167 
                 Probe set 
                 Gene Symbol 
               
               
                   
               
               
                 Standard 
                 −14.61 
                 1097236 
                 235860 
                 224837_at 
                 FOXP1 
               
               
                 Standard 
                 −14.47 
                 1104552 
                 193857 
                 233483_at 
                 LOC96597 
               
               
                 Standard 
                 −13.62 
                 1122645 
                 158341 
                 207641_at 
                 TNFRSF13B 
               
               
                 Standard 
                 −12.05 
                 1135102 
                 349845 
                 209685_s_at 
                 PRKCB1 
               
               
                 Standard 
                 −11.65 
                 1096499 
                 293867 
                 223514_at 
                 CARD11 
               
               
                 Standard 
                 −11.26 
                 1124770 
                 153261 
                 212827_at 
                 IGHM 
               
               
                 Standard 
                 −11.25 
                 1125010 
                 43728 
                 213170_at 
                 GPX7 
               
               
                 Standard 
                 −11.13 
                 1109545 
                 63187 
                 239231_at 
               
               
                 Standard 
                 −10.99 
                 1109220 
                 445977 
                 238880_at 
                 GTF3A 
               
               
                 Standard 
                 −10.87 
                 1131074 
                 76894 
                 201572_x_at 
                 DCTD 
               
               
                 Standard 
                 −10.68 
                 1134517 
                 75807 
                 208690_s_at 
                 PDLIM1 
               
               
                 Standard 
                 −10.63 
                 1098604 
                 32793 
                 226444_at 
                 SLC39A10 
               
               
                 Standard 
                 −10.56 
                 1131219 
                 109150 
                 201810_s_at 
                 SH3BP5 
               
               
                 Standard 
                 −10.52 
                 1120651 
                 80205 
                 204269_at 
                 PIM2 
               
               
                 Standard 
                 −10.39 
                 1133910 
                 167746 
                 207655_s_at 
                 BLNK 
               
               
                 Standard 
                 −10.32 
                 1099396 
                 435949 
                 227346_at 
                 ZNFN1A1 
               
               
                 Standard 
                 −10.25 
                 1529297 
                 132335 
                 Lymph_Dx_015_at 
               
               
                 Standard 
                 −10.17 
                 1107575 
                 424589 
                 237033_at 
                 MGC52498 
               
               
                 Standard 
                 −10.11 
                 1117211 
                 356509 
                 233955_x_at 
                 HSPC195 
               
               
                 Standard 
                 10.06 
                 1129517 
                 −33 
                 220712_at 
               
               
                 Standard 
                 10.29 
                 1139950 
                 437385 
                 220731_s_at 
                 FLJ10420 
               
               
                 Standard 
                 10.35 
                 1097553 
                 197071 
                 225214_at 
                 PSMB7 
               
               
                 Standard 
                 10.41 
                 1119516 
                 6061 
                 201834_at 
                 PRKAB1 
               
               
                 Standard 
                 10.47 
                 1122772 
                 66742 
                 207900_at 
                 CCL17 
               
               
                 Standard 
                 10.55 
                 1132762 
                 80395 
                 204777_s_at 
                 MAL 
               
               
                 Standard 
                 10.77 
                 1099265 
                 375762 
                 227193_at 
               
               
                 Standard 
                 10.81 
                 1095996 
                 288801 
                 222482_at 
                 SSBP3 
               
               
                 Standard 
                 11.14 
                 1100770 
                 65578 
                 228976_at 
               
               
                 Standard 
                 11.19 
                 1133801 
                 181097 
                 207426_s_at 
                 TNFSF4 
               
               
                 Standard 
                 11.61 
                 1099154 
                 97927 
                 227066_at 
                 MOBKL2C 
               
               
                 Standard 
                 11.63 
                 1120370 
                 78877 
                 203723_at 
                 ITPKB 
               
               
                 Standard 
                 11.8 
                 1112674 
                 310320 
                 242794_at 
                 MAML3 
               
               
                 Standard 
                 12.57 
                 1105178 
                 283961 
                 234284_at 
                 GNG8 
               
               
                 Standard 
                 12.63 
                 1124613 
                 296720 
                 212599_at 
                 AUTS2 
               
               
                 Standard 
                 13.28 
                 1106415 
                 169071 
                 235774_at 
               
               
                 Standard 
                 13.3 
                 1121762 
                 32970 
                 206181_at 
                 SLAMF1 
               
               
                 Standard 
                 13.6 
                 1121853 
                 98243 
                 206310_at 
                 SPINK2 
               
               
                 Lymph Node 
                 10.91 
                 1105838 
                 129837 
                 235142_at 
                 ZBTB8 
               
               
                 Lymph Node 
                 10.99 
                 1136273 
                 13775 
                 211597_s_at 
                 HOP 
               
               
                 Lymph Node 
                 11.02 
                 1099418 
                 172792 
                 227370_at 
                 KIAA1946 
               
               
                 Lymph Node 
                 11.46 
                 1124875 
                 18166 
                 212975_at 
                 KIAA0870 
               
               
                 Lymph Node 
                 11.99 
                 1120299 
                 79334 
                 203574_at 
                 NFIL3 
               
               
                 Lymph Node 
                 12.49 
                 1135871 
                 104717 
                 211031_s_at 
                 CYLN2 
               
               
                 Lymph Node 
                 13.33 
                 1121767 
                 458324 
                 206187_at 
                 PTGIR 
               
               
                 Proliferation 
                 −13.17 
                 1138944 
                 84753 
                 218051_s_at 
                 FLJ12442 
               
               
                 Proliferation 
                 −11.61 
                 1116122 
                 42768 
                 227408_s_at 
                 DKFZp761O0113 
               
               
                 Proliferation 
                 −11.16 
                 1110223 
                 212709 
                 239973_at 
               
               
                 Proliferation 
                 −9.93 
                 1120717 
                 444159 
                 204394_at 
                 SLC43A1 
               
               
                 Proliferation 
                 −9.54 
                 1110099 
                 116665 
                 239835_at 
                 TA-KRP 
               
               
                 Proliferation 
                 −9.49 
                 1130942 
                 445977 
                 201338_x_at 
                 GTF3A 
               
               
                 Proliferation 
                 −9.28 
                 1123192 
                 315177 
                 209100_at 
                 IFRD2 
               
               
                 Proliferation 
                 −9.14 
                 1135492 
                 408615 
                 210448_s_at 
                 P2RX5 
               
               
                 Proliferation 
                 −9.03 
                 1120011 
                 3068 
                 202983_at 
                 SMARCA3 
               
               
                 Proliferation 
                 −9.01 
                 1096738 
                 87968 
                 223903_at 
                 TLR9 
               
               
                 Proliferation 
                 −8.91 
                 1108961 
                 292088 
                 238593_at 
                 FLJ22531 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                 Standard 
                 Lymph Node 
                 Proliferation 
               
               
                   
                   
               
               
                   
                 Mean ABC 
                 −849.47 
                 531.79 
                 −1027.48 
                 Cut 1 
                 0.20 
               
               
                   
                 Mean PMBL 
                 27.99 
                 750.84 
                 −872.43 
                 Cut 2 
                 0.80 
               
               
                   
                 Covariance ABC 
                 14028.46 
                 3705.84 
                 3118.60 
               
               
                   
                   
                 3705.84 
                 2326.91 
                 1083.37 
               
               
                   
                   
                 3118.60 
                 1083.37 
                 1589.42 
               
               
                   
                 Covariance PMBL 
                 19425.29 
                 5109.98 
                 2199.28 
               
               
                   
                   
                 5109.98 
                 2084.28 
                 620.86 
               
               
                   
                   
                 2199.28 
                 620.86 
                 1028.44 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2402 
               
               
                   
               
               
                 BL vs. GCB 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Signature 
                 Scale 
                 UNIQID 
                 Unigene ID Build 167 
                 Probe set 
                 Gene Symbol 
               
               
                   
               
               
                 Standard 
                 −12.78 
                 1131246 
                 153752 
                 201853_s_at 
                 CDC25B 
               
               
                 Standard 
                 −11.35 
                 1099444 
                 434489 
                 227407_at 
                 FLJ90013 
               
               
                 Standard 
                 −10.4 
                 1116432 
                 409362 
                 229356_x_at 
                 KIAA1259 
               
               
                 Standard 
                 −10.3 
                 1134582 
                 78202 
                 208794_s_at 
                 SMARCA4 
               
               
                 Standard 
                 −10.01 
                 1133998 
                 76884 
                 207826_s_at 
                 ID3 
               
               
                 Standard 
                 −9.3 
                 1126081 
                 309763 
                 215030_at 
                 GRSF1 
               
               
                 Standard 
                 −9.19 
                 1096503 
                 21379 
                 223522_at 
                 C9orf45 
               
               
                 Standard 
                 −8.95 
                 1529340 
                 −99 
                 Lymph_Dx_061_at 
               
               
                 Standard 
                 −8.88 
                 1138128 
                 390428 
                 216199_s_at 
                 MAP3K4 
               
               
                 Standard 
                 −8.8 
                 1099152 
                 351247 
                 227064_at 
                 MGC15396 
               
               
                 Standard 
                 −8.69 
                 1133757 
                 6113 
                 207320_x_at 
                 STAU 
               
               
                 Standard 
                 −8.54 
                 1116593 
                 422889 
                 230329_s_at 
                 NUDT6 
               
               
                 Standard 
                 −8.4 
                 1130926 
                 508741 
                 201310_s_at 
                 C5orf13 
               
               
                 Standard 
                 −8.39 
                 1135685 
                 371282 
                 210776_x_at 
                 TCF3 
               
               
                 Standard 
                 −8.39 
                 1140520 
                 11747 
                 221741_s_at 
                 C20orf21 
               
               
                 Standard 
                 −8.34 
                 1119802 
                 7370 
                 202522_at 
                 PITPNB 
               
               
                 Standard 
                 −8.31 
                 1096149 
                 410205 
                 222824_at 
                 NUDT5 
               
               
                 Standard 
                 −8.23 
                 1124786 
                 22370 
                 212847_at 
                 NEXN 
               
               
                 Standard 
                 −8.07 
                 1098012 
                 355669 
                 225756_at 
                 CSNK1E 
               
               
                 Standard 
                 −7.89 
                 1116317 
                 526415 
                 228661_s_at 
               
               
                 Standard 
                 −7.86 
                 1109195 
                 416155 
                 238853_at 
               
               
                 Standard 
                 −7.71 
                 1134880 
                 168799 
                 209265_s_at 
                 METTL3 
               
               
                 Standard 
                 −7.66 
                 1529298 
                 136707 
                 Lymph_Dx_016_at 
               
               
                 Standard 
                 −7.55 
                 1128660 
                 413071 
                 219471_at 
                 C13orf18 
               
               
                 Standard 
                 −7.55 
                 1138973 
                 11270 
                 218097_s_at 
                 C10orf66 
               
               
                 Standard 
                 −7.46 
                 1127294 
                 421986 
                 217028_at 
                 CXCR4 
               
               
                 Standard 
                 7.47 
                 1134270 
                 352119 
                 208284_x_at 
                 GGT1 
               
               
                 Standard 
                 7.48 
                 1120743 
                 79197 
                 204440_at 
                 CD83 
               
               
                 Standard 
                 7.5 
                 1098179 
                 163725 
                 225956_at 
                 LOC153222 
               
               
                 Standard 
                 7.55 
                 1121400 
                 223474 
                 205599_at 
                 TRAF1 
               
               
                 Standard 
                 7.59 
                 1114967 
                 7905 
                 223028_s_at 
                 SNX9 
               
               
                 Standard 
                 7.6 
                 1122087 
                 72927 
                 206693_at 
                 IL7 
               
               
                 Standard 
                 7.64 
                 1101905 
                 170843 
                 230345_at 
               
               
                 Standard 
                 7.77 
                 1120700 
                 410745 
                 204362_at 
                 SCAP2 
               
               
                 Standard 
                 7.8 
                 1120572 
                 84 
                 204116_at 
                 IL2RG 
               
               
                 Standard 
                 7.84 
                 1098271 
                 300670 
                 226056_at 
                 CDGAP 
               
               
                 Standard 
                 7.9 
                 1115073 
                 131315 
                 223220_s_at 
                 BAL 
               
               
                 Standard 
                 7.9 
                 1133210 
                 434374 
                 205842_s_at 
                 JAK2 
               
               
                 Standard 
                 8 
                 1129269 
                 62919 
                 220358_at 
                 SNFT 
               
               
                 Standard 
                 8.01 
                 1131940 
                 1103 
                 203085_s_at 
                 TGFB1 
               
               
                 Standard 
                 8.07 
                 1098506 
                 193400 
                 226333_at 
                 IL6R 
               
               
                 Standard 
                 8.13 
                 1120601 
                 441129 
                 204166_at 
                 KIAA0963 
               
               
                 Standard 
                 8.21 
                 1102540 
                 434881 
                 231093_at 
                 FCRH3 
               
               
                 Standard 
                 8.24 
                 1121695 
                 511759 
                 206082_at 
                 HCP5 
               
               
                 Standard 
                 8.33 
                 1136877 
                 409934 
                 212998_x_at 
                 HLA-DQB1 
               
               
                 Standard 
                 8.37 
                 1100138 
                 278391 
                 228234_at 
                 TIRP 
               
               
                 Standard 
                 8.46 
                 1126293 
                 504816 
                 215346_at 
                 TNFRSF5 
               
               
                 Standard 
                 8.46 
                 1127805 
                 380627 
                 217947_at 
                 CKLFSF6 
               
               
                 Standard 
                 8.59 
                 1136573 
                 914 
                 211991_s_at 
                 HLA-DPA1 
               
               
                 Standard 
                 8.62 
                 1119111 
                 35052 
                 200804_at 
                 TEGT 
               
               
                 Standard 
                 8.7 
                 1136329 
                 132739 
                 211675_s_at 
                 HIC 
               
               
                 Standard 
                 8.74 
                 1123690 
                 111805 
                 210176_at 
                 TLR1 
               
               
                 Standard 
                 8.81 
                 1138677 
                 390440 
                 217436_x_at 
               
               
                 Standard 
                 8.89 
                 1113993 
                 131811 
                 244286_at 
               
               
                 Standard 
                 8.89 
                 1132651 
                 439767 
                 204529_s_at 
                 TOX 
               
               
                 Standard 
                 8.91 
                 1119566 
                 433506 
                 201954_at 
                 ARPC1B 
               
               
                 Standard 
                 9.01 
                 1128626 
                 501452 
                 219424_at 
                 EBI3 
               
               
                 Standard 
                 9.17 
                 1101272 
                 179089 
                 229584_at 
                 DKFZp434H2111 
               
               
                 Standard 
                 9.33 
                 1136777 
                 387679 
                 212671_s_at 
                 HLA-DQA1 
               
               
                 Standard 
                 9.33 
                 1109756 
                 530304 
                 239453_at 
               
               
                 Standard 
                 9.4 
                 1136216 
                 512152 
                 211528_x_at 
                 HLA-G 
               
               
                 Standard 
                 9.4 
                 1124381 
                 440808 
                 212288_at 
                 FNBP1 
               
               
                 Standard 
                 9.46 
                 1099680 
                 210387 
                 227677_at 
                 JAK3 
               
               
                 Standard 
                 9.49 
                 1109913 
                 355724 
                 239629_at 
                 CFLAR 
               
               
                 Standard 
                 9.55 
                 1132636 
                 306278 
                 204490_s_at 
                 CD44 
               
               
                 Standard 
                 9.59 
                 1119243 
                 440165 
                 201171_at 
                 ATP6V0E 
               
               
                 Standard 
                 9.72 
                 1101149 
                 517226 
                 229437_at 
                 BIC 
               
               
                 Standard 
                 9.8 
                 1130674 
                 381008 
                 200905_x_at 
                 HLA-E 
               
               
                 Standard 
                 10.34 
                 1119939 
                 170087 
                 202820_at 
                 AHR 
               
               
                 Standard 
                 10.44 
                 1132883 
                 432453 
                 205027_s_at 
                 MAP3K8 
               
               
                 Standard 
                 10.74 
                 1121452 
                 227817 
                 205681_at 
                 BCL2A1 
               
               
                 Standard 
                 10.84 
                 1137360 
                 429658 
                 214196_s_at 
                 CLN2 
               
               
                 Standard 
                 12.08 
                 1132520 
                 283063 
                 204249_s_at 
                 LMO2 
               
               
                 Standard 
                 12.33 
                 1131497 
                 114931 
                 202295_s_at 
                 CTSH 
               
               
                 Standard 
                 13.58 
                 1123163 
                 421342 
                 208991_at 
                 STAT3 
               
               
                 Lymph Node 
                 −9.1 
                 1138136 
                 433574 
                 216215_s_at 
                 RBM9 
               
               
                 Lymph Node 
                 8.78 
                 1130121 
                 411958 
                 221978_at 
                 HLA-F 
               
               
                 Lymph Node 
                 9.22 
                 1139830 
                 221851 
                 220330_s_at 
                 SAMSN1 
               
               
                 Lymph Node 
                 9.23 
                 1131705 
                 386467 
                 202638_s_at 
                 ICAM1 
               
               
                 Lymph Node 
                 9.62 
                 1130168 
                 75626 
                 222061_at 
                 CD58 
               
               
                 Lymph Node 
                 9.66 
                 1121844 
                 83077 
                 206295_at 
                 IL18 
               
               
                 Lymph Node 
                 9.68 
                 1121000 
                 519033 
                 204924_at 
                 TLR2 
               
               
                 Lymph Node 
                 9.83 
                 1102437 
                 437023 
                 230966_at 
                 IL4I1 
               
               
                 Lymph Node 
                 10.71 
                 1119475 
                 296323 
                 201739_at 
                 SGK 
               
               
                 Lymph Node 
                 11.09 
                 1131786 
                 375957 
                 202803_s_at 
                 ITGB2 
               
               
                 Proliferation 
                 −11.07 
                 1133141 
                 344524 
                 205677_s_at 
                 DLEU1 
               
               
                 Proliferation 
                 −10.04 
                 1138259 
                 89525 
                 216484_x_at 
                 HDGF 
               
               
                 Proliferation 
                 −9.74 
                 1131578 
                 202453 
                 202431_s_at 
                 MYC 
               
               
                 Proliferation 
                 −9.45 
                 1137449 
                 223745 
                 214363_s_at 
                 MATR3 
               
               
                 Proliferation 
                 −9.43 
                 1130468 
                 166463 
                 200594_x_at 
                 HNRPU 
               
               
                 Proliferation 
                 −9.21 
                 1138157 
                 82563 
                 216251_s_at 
                 KIAA0153 
               
               
                 Proliferation 
                 −9.15 
                 1127756 
                 313544 
                 217850_at 
                 NS 
               
               
                 Proliferation 
                 −9 
                 1130433 
                 246112 
                 200058_s_at 
                 U5-200KD 
               
               
                 Proliferation 
                 −8.76 
                 1123108 
                 108112 
                 208828_at 
                 POLE3 
               
               
                 Proliferation 
                 −8.75 
                 1128738 
                 335550 
                 219581_at 
                 MGC2776 
               
               
                 Proliferation 
                 −8.74 
                 1122400 
                 439911 
                 207199_at 
                 TERT 
               
               
                 Proliferation 
                 −8.66 
                 1097948 
                 69476 
                 225684_at 
                 LOC348235 
               
               
                 Proliferation 
                 −8.6 
                 1119460 
                 76122 
                 201696_at 
                 SFRS4 
               
               
                 Proliferation 
                 −8.6 
                 1136401 
                 27258 
                 211761_s_at 
                 SIP 
               
               
                 Proliferation 
                 −8.58 
                 1099088 
                 14355 
                 226996_at 
               
               
                 Proliferation 
                 −8.51 
                 1134653 
                 253536 
                 208901_s_at 
                 TOP1 
               
               
                 Proliferation 
                 −8.49 
                 1140584 
                 294083 
                 221932_s_at 
                 C14orf87 
               
               
                 Proliferation 
                 −8.43 
                 1121309 
                 23642 
                 205449_at 
                 HSU79266 
               
               
                 Proliferation 
                 −8.43 
                 1120385 
                 36708 
                 203755_at 
                 BUB1B 
               
               
                 Proliferation 
                 −8.38 
                 1136710 
                 75782 
                 212429_s_at 
                 GTF3C2 
               
               
                 Proliferation 
                 −8.36 
                 1136605 
                 448398 
                 212064_x_at 
                 MAZ 
               
               
                 Proliferation 
                 −8.24 
                 1120697 
                 323462 
                 204355_at 
                 DHX30 
               
               
                 Proliferation 
                 −8.19 
                 1127833 
                 382044 
                 218001_at 
                 MRPS2 
               
               
                 Proliferation 
                 −8.11 
                 1096903 
                 437460 
                 224185_at 
                 FLJ10385 
               
               
                 Proliferation 
                 −8.1 
                 1120596 
                 4854 
                 204159_at 
                 CDKN2C 
               
               
                 Proliferation 
                 −8.1 
                 1120779 
                 28853 
                 204510_at 
                 CDC7 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                 Standard 
                 Lymph Node 
                 Proliferation 
               
               
                   
                   
               
               
                   
                 Mean BL 
                 1098.69 
                 576.05 
                 −2392.12 
                 Cut 1 
                 0.09 
               
               
                   
                 Mean GCB 
                 2187.37 
                 768.53 
                 −2129.35 
                 Cut 2 
                 0.53 
               
               
                   
                 Covariance BL 
                 75263.67 
                 12684.43 
                 15734.77 
               
               
                   
                   
                 12684.43 
                 2650.81 
                 2358.05 
               
               
                   
                   
                 15734.77 
                 2358.05 
                 4653.00 
               
               
                   
                 Covariance GCB 
                 50548.22 
                 9301.12 
                 14182.83 
               
               
                   
                   
                 9301.12 
                 2602.51 
                 3028.21 
               
               
                   
                   
                 14182.83 
                 3028.21 
                 5983.04 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2403 
               
               
                   
               
               
                 BL vs. PMBL 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Signature 
                 Scale 
                 UNIQID 
                 Unigene ID Build 167 
                 Probe set 
                 Gene Symbol 
               
               
                   
               
               
                 Standard 
                 −13.54 
                 1099444 
                 434489 
                 227407_at 
                 FLJ90013 
               
               
                 Standard 
                 −13.42 
                 1096503 
                 21379 
                 223522_at 
                 C9orf45 
               
               
                 Standard 
                 −13.36 
                 1130114 
                 445084 
                 221965_at 
                 MPHOSPH9 
               
               
                 Standard 
                 −13.27 
                 1124786 
                 22370 
                 212847_at 
                 NEXN 
               
               
                 Standard 
                 −13.27 
                 1134582 
                 78202 
                 208794_s_at 
                 SMARCA4 
               
               
                 Standard 
                 −12.37 
                 1096149 
                 410205 
                 222824_at 
                 NUDT5 
               
               
                 Standard 
                 −11.95 
                 1130855 
                 77515 
                 201189_s_at 
                 ITPR3 
               
               
                 Standard 
                 −11.66 
                 1529298 
                 136707 
                 Lymph_Dx_016_at 
               
               
                 Standard 
                 −11.35 
                 1131246 
                 153752 
                 201853_s_at 
                 CDC25B 
               
               
                 Standard 
                 −11.17 
                 1136925 
                 436939 
                 213154_s_at 
                 BICD2 
               
               
                 Standard 
                 −11.08 
                 1124188 
                 282346 
                 211987_at 
                 TOP2B 
               
               
                 Standard 
                 −11.06 
                 1133998 
                 76884 
                 207826_s_at 
                 ID3 
               
               
                 Standard 
                 −10.76 
                 1139266 
                 76640 
                 218723_s_at 
                 RGC32 
               
               
                 Standard 
                 −10.74 
                 1134880 
                 168799 
                 209265_s_at 
                 METTL3 
               
               
                 Standard 
                 −10.69 
                 1140520 
                 11747 
                 221741_s_at 
                 C20orf21 
               
               
                 Standard 
                 −10.6 
                 1109545 
                 63187 
                 239231_at 
               
               
                 Standard 
                 −10.55 
                 1106043 
                 266331 
                 235372_at 
                 FREB 
               
               
                 Standard 
                 −10.52 
                 1110214 
                 144519 
                 239964_at 
                 TCL6 
               
               
                 Standard 
                 −10.49 
                 1098592 
                 283707 
                 226431_at 
                 ALS2CR13 
               
               
                 Standard 
                 −10.45 
                 1109220 
                 445977 
                 238880_at 
                 GTF3A 
               
               
                 Standard 
                 −10.41 
                 1131263 
                 249955 
                 201877_s_at 
                 PPP2R5C 
               
               
                 Standard 
                 10.54 
                 1122772 
                 66742 
                 207900_at 
                 CCL17 
               
               
                 Standard 
                 10.59 
                 1109913 
                 355724 
                 239629_at 
                 CFLAR 
               
               
                 Standard 
                 10.82 
                 1119884 
                 418004 
                 202716_at 
                 PTPN1 
               
               
                 Standard 
                 10.83 
                 1135189 
                 137569 
                 209863_s_at 
                 TP73L 
               
               
                 Standard 
                 10.89 
                 1123437 
                 73090 
                 209636_at 
                 NFKB2 
               
               
                 Standard 
                 11.15 
                 1124381 
                 440808 
                 212288_at 
                 FNBP1 
               
               
                 Standard 
                 11.26 
                 1108237 
                 126232 
                 237753_at 
               
               
                 Standard 
                 11.34 
                 1101149 
                 517226 
                 229437_at 
                 BIC 
               
               
                 Standard 
                 11.77 
                 1139774 
                 15827 
                 220140_s_at 
                 SNX11 
               
               
                 Standard 
                 11.87 
                 1123163 
                 421342 
                 208991_at 
                 STAT3 
               
               
                 Standard 
                 11.93 
                 1129269 
                 62919 
                 220358_at 
                 SNFT 
               
               
                 Standard 
                 12.03 
                 1132636 
                 306278 
                 204490_s_at 
                 CD44 
               
               
                 Standard 
                 12.1 
                 1138677 
                 390440 
                 217436_x_at 
               
               
                 Standard 
                 12.2 
                 1139950 
                 437385 
                 220731_s_at 
                 FLJ10420 
               
               
                 Standard 
                 12.25 
                 1134270 
                 352119 
                 208284_x_at 
                 GGT1 
               
               
                 Standard 
                 12.27 
                 1136216 
                 512152 
                 211528_x_at 
                 HLA-G 
               
               
                 Standard 
                 12.79 
                 1121400 
                 223474 
                 205599_at 
                 TRAF1 
               
               
                 Standard 
                 12.82 
                 1119939 
                 170087 
                 202820_at 
                 AHR 
               
               
                 Standard 
                 13.12 
                 1126293 
                 504816 
                 215346_at 
                 TNFRSF5 
               
               
                 Standard 
                 13.44 
                 1100138 
                 278391 
                 228234_at 
                 TIRP 
               
               
                 Standard 
                 13.74 
                 1132883 
                 432453 
                 205027_s_at 
                 MAP3K8 
               
               
                 Standard 
                 13.94 
                 1131497 
                 114931 
                 202295_s_at 
                 CTSH 
               
               
                 Standard 
                 14.15 
                 1121762 
                 32970 
                 206181_at 
                 SLAMF1 
               
               
                 Standard 
                 14.51 
                 1132520 
                 283063 
                 204249_s_at 
                 LMO2 
               
               
                 Standard 
                 14.68 
                 1121452 
                 227817 
                 205681_at 
                 BCL2A1 
               
               
                 Standard 
                 15.24 
                 1105178 
                 283961 
                 234284_at 
                 GNG8 
               
               
                 Lymph Node 
                 10.95 
                 1121205 
                 2488 
                 205269_at 
                 LCP2 
               
               
                 Lymph Node 
                 11.22 
                 1140845 
                 21486 
                 AFFX- 
                 STAT1 
               
               
                   
                   
                   
                   
                 HUMISGF3A/M 
               
               
                   
                   
                   
                   
                 97935_3_at 
               
               
                 Lymph Node 
                 11.45 
                 1131068 
                 118400 
                 201564_s_at 
                 FSCN1 
               
               
                 Lymph Node 
                 11.92 
                 1131705 
                 386467 
                 202638_s_at 
                 ICAM1 
               
               
                 Lymph Node 
                 12.06 
                 1131038 
                 81328 
                 201502_s_at 
                 NFKBIA 
               
               
                 Lymph Node 
                 12.49 
                 1121444 
                 153563 
                 205668_at 
                 LY75 
               
               
                 Lymph Node 
                 13.01 
                 1123457 
                 446304 
                 209684_at 
                 RIN2 
               
               
                 Lymph Node 
                 13.19 
                 1140404 
                 354740 
                 221584_s_at 
                 KCNMA1 
               
               
                 Lymph Node 
                 13.26 
                 1124875 
                 18166 
                 212975_at 
                 KIAA0870 
               
               
                 Lymph Node 
                 14.06 
                 1102437 
                 437023 
                 230966_at 
                 IL4I1 
               
               
                 Lymph Node 
                 14.11 
                 1132766 
                 82359 
                 204781_s_at 
                 TNFRSF6 
               
               
                 Lymph Node 
                 15.31 
                 1121767 
                 458324 
                 206187_at 
                 PTGIR 
               
               
                 Lymph Node 
                 15.32 
                 1135871 
                 104717 
                 211031_s_at 
                 CYLN2 
               
               
                 Lymph Node 
                 15.34 
                 1138652 
                 444471 
                 217388_s_at 
                 KYNU 
               
               
                 Lymph Node 
                 16.01 
                 1139830 
                 221851 
                 220330_s_at 
                 SAMSN1 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                 Standard 
                 Lymph Node 
               
               
                   
                   
               
               
                   
                 Mean BL 
                 −66.97 
                 1445.63 
                 Cut 1 
                 0.20 
               
               
                   
                 Mean PMBL 
                 1205.38 
                 2041.25 
                 Cut 2 
                 0.80 
               
               
                   
                 Covariance BL 
                 35263.67 
                 13424.88 
               
               
                   
                   
                 13424.88 
                 7458.56 
               
               
                   
                 Covariance PMBL 
                 12064.38 
                 5113.74 
               
               
                   
                   
                 5113.74 
                 3216.53 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2404 
               
               
                   
               
               
                 FH vs. DLBCL-BL 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Signature 
                 Scale 
                 UNIQID 
                 Unigene ID Build 167 
                 Probe set 
                 Gene Symbol 
               
               
                   
               
               
                 Standard 
                 −12.81 
                 1104910 
                 458262 
                 233969_at 
                 IGL@ 
               
               
                 Standard 
                 −11.54 
                 1102898 
                 145519 
                 231496_at 
                 FKSG87 
               
               
                 Standard 
                 −11.46 
                 1117298 
                 449586 
                 234366_x_at 
               
               
                 Standard 
                 −11.46 
                 1132973 
                 169294 
                 205255_x_at 
                 TCF7 
               
               
                 Standard 
                 −11.22 
                 1133099 
                 88646 
                 205554_s_at 
                 DNASE1L3 
               
               
                 Standard 
                 −10.76 
                 1131531 
                 153647 
                 202350_s_at 
                 MATN2 
               
               
                 Standard 
                 −10.59 
                 1124283 
                 406612 
                 212144_at 
                 UNC84B 
               
               
                 Standard 
                 −10.35 
                 1099847 
                 36723 
                 227867_at 
                 LOC129293 
               
               
                 Standard 
                 −10.22 
                 1136430 
                 102950 
                 211798_x_at 
                 IGLJ3 
               
               
                 Standard 
                 −10.05 
                 1117394 
                 −13 
                 234792_x_at 
               
               
                 Standard 
                 −9.95 
                 1133047 
                 528338 
                 205434_s_at 
                 AAK1 
               
               
                 Standard 
                 −9.95 
                 1098865 
                 250905 
                 226741_at 
                 LOC51234 
               
               
                 Standard 
                 −9.82 
                 1108515 
                 98132 
                 238071_at 
                 LCN6 
               
               
                 Standard 
                 −9.8 
                 1131407 
                 154248 
                 202125_s_at 
                 ALS2CR3 
               
               
                 Standard 
                 −9.77 
                 1128469 
                 390817 
                 219173_at 
                 FLJ22686 
               
               
                 Standard 
                 −9.7 
                 1123875 
                 428 
                 210607_at 
                 FLT3LG 
               
               
                 Standard 
                 −9.69 
                 1131875 
                 169172 
                 202965_s_at 
                 CAPN6 
               
               
                 Standard 
                 −9.69 
                 1135173 
                 3781 
                 209841_s_at 
                 LRRN3 
               
               
                 Standard 
                 −9.48 
                 1099798 
                 411081 
                 227811_at 
                 FGD3 
               
               
                 Standard 
                 −9.41 
                 1119046 
                 349499 
                 200606_at 
                 DSP 
               
               
                 Standard 
                 −9.36 
                 1122449 
                 278694 
                 207277_at 
                 CD209 
               
               
                 Standard 
                 −9.34 
                 1114017 
                 133255 
                 244313_at 
               
               
                 Standard 
                 −9.34 
                 1122767 
                 652 
                 207892_at 
                 TNFSF5 
               
               
                 Standard 
                 −9.24 
                 1123369 
                 79025 
                 209481_at 
                 SNRK 
               
               
                 Standard 
                 −9.16 
                 1098954 
                 128905 
                 226844_at 
                 MOBKL2B 
               
               
                 Standard 
                 −9.14 
                 1135513 
                 421437 
                 210481_s_at 
                 CD209L 
               
               
                 Standard 
                 −9.08 
                 1100904 
                 426296 
                 229145_at 
                 LOC119504 
               
               
                 Standard 
                 −8.99 
                 1122738 
                 81743 
                 207840_at 
                 CD160 
               
               
                 Standard 
                 −8.94 
                 1120925 
                 204891 
                 204773_at 
                 IL11RA 
               
               
                 Standard 
                 9.09 
                 1123055 
                 185726 
                 208691_at 
                 TFRC 
               
               
                 Standard 
                 9.62 
                 1134858 
                 405954 
                 209226_s_at 
                 TNPO1 
               
               
                 Standard 
                 10.19 
                 1123052 
                 180909 
                 208680_at 
                 PRDX1 
               
               
                 Standard 
                 10.81 
                 1124178 
                 446579 
                 211969_at 
                 HSPCA 
               
               
                 Lymph Node 
                 −10.59 
                 1137597 
                 3903 
                 214721_x_at 
                 CDC42EP4 
               
               
                 Lymph Node 
                 −9.69 
                 1119684 
                 439586 
                 202242_at 
                 TM4SF2 
               
               
                 Lymph Node 
                 −9.25 
                 1125593 
                 8910 
                 214180_at 
                 MAN1C1 
               
               
                 Lymph Node 
                 −8.44 
                 1124318 
                 21858 
                 212190_at 
                 SERPINE2 
               
               
                 Lymph Node 
                 −8.09 
                 1119448 
                 212296 
                 201656_at 
                 ITGA6 
               
               
                 Lymph Node 
                 −8.07 
                 1125546 
                 125036 
                 214081_at 
                 PLXDC1 
               
               
                 Lymph Node 
                 −7.7 
                 1097683 
                 132569 
                 225373_at 
                 PP2135 
               
               
                 Lymph Node 
                 −7.56 
                 1101305 
                 112742 
                 229623_at 
               
               
                 Lymph Node 
                 7.45 
                 1135240 
                 436852 
                 209955_s_at 
                 FAP 
               
               
                 Proliferation 
                 6.97 
                 1135101 
                 20830 
                 209680_s_at 
                 KIFC1 
               
               
                 Proliferation 
                 7.03 
                 1130426 
                 432607 
                 200039_s_at 
                 PSMB2 
               
               
                 Proliferation 
                 7.04 
                 1130501 
                 2795 
                 200650_s_at 
                 LDHA 
               
               
                 Proliferation 
                 7.08 
                 1130744 
                 158688 
                 201027_s_at 
                 EIF5B 
               
               
                 Proliferation 
                 7.23 
                 1137506 
                 75258 
                 214501_s_at 
                 H2AFY 
               
               
                 Proliferation 
                 7.32 
                 1131474 
                 95577 
                 202246_s_at 
                 CDK4 
               
               
                 Proliferation 
                 7.39 
                 1130871 
                 159087 
                 201222_s_at 
                 RAD23B 
               
               
                 Proliferation 
                 7.42 
                 1119375 
                 381072 
                 201489_at 
                 PPIF 
               
               
                 Proliferation 
                 7.47 
                 1136595 
                 404814 
                 212038_s_at 
                 VDAC1 
               
               
                 Proliferation 
                 7.7 
                 1135858 
                 90093 
                 211015_s_at 
                 HSPA4 
               
               
                 Proliferation 
                 7.78 
                 1130527 
                 184233 
                 200692_s_at 
                 HSPA9B 
               
               
                 Proliferation 
                 7.78 
                 1130820 
                 151777 
                 201144_s_at 
                 EIF2S1 
               
               
                 Proliferation 
                 7.83 
                 1115829 
                 433213 
                 225253_s_at 
                 METTL2 
               
               
                 Proliferation 
                 7.84 
                 1134699 
                 439683 
                 208974_x_at 
                 KPNB1 
               
               
                 Proliferation 
                 7.87 
                 1120274 
                 31584 
                 203517_at 
                 MTX2 
               
               
                 Proliferation 
                 7.92 
                 1136786 
                 63788 
                 212694_s_at 
                 PCCB 
               
               
                 Proliferation 
                 7.95 
                 1097172 
                 434886 
                 224753_at 
                 CDCA5 
               
               
                 Proliferation 
                 8.4 
                 1138537 
                 −12 
                 217140_s_at 
               
               
                 Proliferation 
                 8.53 
                 1119488 
                 154672 
                 201761_at 
                 MTHFD2 
               
               
                 Proliferation 
                 8.58 
                 1130799 
                 233952 
                 201114_x_at 
                 PSMA7 
               
               
                 Proliferation 
                 8.72 
                 1135673 
                 82159 
                 210759_s_at 
                 PSMA1 
               
               
                 Proliferation 
                 9.4 
                 1114679 
                 16470 
                 222503_s_at 
                 FLJ10904 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Standard 
                 Lymph Node 
                 Proliferation 
               
               
                   
               
               
                 Mean FH 
                 −2193.59 
                 −588.21 
                 1571.78 
                 Cut 1 
                 0.50 
               
               
                 Mean DLBCL-BL 
                 −1448.27 
                 −441.91 
                 1735.00 
                 Cut 2 
                 0.92 
               
               
                 Covariance FH 
                 6729.73 
                 1223.99 
                 2541.22 
               
               
                   
                 1223.99 
                 405.22 
                 293.72 
               
               
                   
                 2541.22 
                 293.72 
                 1797.58 
               
               
                 Covariance DLBCL-BL 
                 17675.23 
                 3642.41 
                 4158.43 
               
               
                   
                 3642.41 
                 1379.81 
                 1066.48 
               
               
                   
                 4158.43 
                 1066.48 
                 2858.21 
               
               
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2405 
               
               
                   
               
               
                 FH vs. FL 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Signature 
                 Scale 
                 UNIQID 
                 Unigene ID Build 167 
                 Probe set 
                 Gene Symbol 
               
               
                   
               
               
                 Standard 
                 −11.23 
                 1117298 
                 449586 
                 234366_x_at 
               
               
                 Standard 
                 −10.62 
                 1121953 
                 38365 
                 206478_at 
                 KIAA0125 
               
               
                 Standard 
                 −10.6 
                 1104910 
                 458262 
                 233969_at 
                 IGL@ 
               
               
                 Standard 
                 −10.39 
                 1136430 
                 102950 
                 211798_x_at 
                 IGLJ3 
               
               
                 Standard 
                 −9.96 
                 1129281 
                 395486 
                 220377_at 
                 C14orf110 
               
               
                 Standard 
                 −9.73 
                 1118835 
                 102336 
                 47069_at 
                 ARHGAP8 
               
               
                 Standard 
                 −9.21 
                 1127807 
                 7236 
                 217950_at 
                 NOSIP 
               
               
                 Standard 
                 −9.05 
                 1128377 
                 371003 
                 219014_at 
                 PLAC8 
               
               
                 Standard 
                 −8.85 
                 1101004 
                 2969 
                 229265_at 
                 SKI 
               
               
                 Standard 
                 9.06 
                 1139411 
                 368238 
                 219073_s_at 
                 OSBPL10 
               
               
                 Standard 
                 9.07 
                 1120789 
                 154729 
                 204524_at 
                 PDPK1 
               
               
                 Standard 
                 9.21 
                 1136464 
                 159428 
                 211833_s_at 
                 BAX 
               
               
                 Standard 
                 9.29 
                 1125279 
                 445652 
                 213575_at 
                 TRA2A 
               
               
                 Standard 
                 9.45 
                 1529390 
                 79241 
                 Lymph_Dx_120_at 
                 BCL2 
               
               
                 Standard 
                 9.52 
                 1132022 
                 173911 
                 203247_s_at 
                 ZNF24 
               
               
                 Standard 
                 9.57 
                 1139645 
                 134051 
                 219757_s_at 
                 C14orf101 
               
               
                 Standard 
                 9.64 
                 1137561 
                 67397 
                 214639_s_at 
                 HOXA1 
               
               
                 Standard 
                 9.66 
                 1114893 
                 314623 
                 222891_s_at 
                 BCL11A 
               
               
                 Standard 
                 10.38 
                 1098095 
                 131059 
                 225852_at 
                 ANKRD17 
               
               
                 Standard 
                 10.4 
                 1134858 
                 405954 
                 209226_s_at 
                 TNPO1 
               
               
                 Standard 
                 12.65 
                 1101054 
                 173328 
                 229322_at 
                 PPP2R5E 
               
               
                 Standard 
                 12.79 
                 1124178 
                 446579 
                 211969_at 
                 HSPCA 
               
               
                 Standard 
                 13.34 
                 1135489 
                 288178 
                 210438_x_at 
                 SSA2 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                 Standard 
               
               
                   
                   
               
               
                   
                 Mean FH 
                 136.43 
                 Cut 1 
                 0.50 
               
               
                   
                 Mean FL 
                 640.38 
                 Cut 2 
                 0.99 
               
               
                   
                 Covariance FH 
                 10719.40 
               
               
                   
                 Covariance FL 
                 9373.11 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2406 
               
               
                   
               
               
                 FH vs. MCL 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Signature 
                 Scale 
                 UNIQID 
                 Unigene ID Build 167 
                 Probe set 
                 Gene Symbol 
               
               
                   
               
               
                 Standard 
                 13.05 
                 1100258 
                 88442 
                 228377_at 
                 KIAA1384 
               
               
                 Standard 
                 13.43 
                 1529382 
                 371468 
                 Lymph_Dx_111_at 
                 CCND1 
               
               
                 Standard 
                 13.54 
                 1106855 
                 455101 
                 236255_at 
                 KIAA1909 
               
               
                 Standard 
                 13.73 
                 1529308 
                 193014 
                 Lymph_Dx_027_x_at 
               
               
                 Standard 
                 14.56 
                 1100873 
                 445884 
                 229103_at 
               
               
                 Standard 
                 21.12 
                 1132834 
                 432638 
                 204914_s_at 
                 SOX11 
               
               
                 Lymph Node 
                 −8.44 
                 1130378 
                 234434 
                 44783_s_at 
                 HEY1 
               
               
                 Lymph Node 
                 −7.92 
                 1123552 
                 423077 
                 209879_at 
                 SELPLG 
               
               
                 Lymph Node 
                 −7.7 
                 1131218 
                 76753 
                 201809_s_at 
                 ENG 
               
               
                 Lymph Node 
                 −7.4 
                 1097683 
                 132569 
                 225373_at 
                 PP2135 
               
               
                 Lymph Node 
                 −7.15 
                 1136273 
                 13775 
                 211597_s_at 
                 HOP 
               
               
                 Lymph Node 
                 14.16 
                 1134532 
                 371468 
                 208711_s_at 
                 CCND1 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                 Standard 
                 Lymph Node 
               
               
                   
                   
               
               
                   
                 Mean FH 
                 451.68 
                 −282.65 
                 Cut 1 
                 0.20 
               
               
                   
                 Mean MCFL 
                 863.16 
                 −156.82 
                 Cut 2 
                 0.80 
               
               
                   
                 Covariance FH 
                 1617.92 
                 222.89 
               
               
                   
                   
                 222.89 
                 271.65 
               
               
                   
                 Covariance MCL 
                 3154.38 
                 917.30 
               
               
                   
                   
                 917.30 
                 659.94 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2407 
               
               
                   
               
               
                 FH vs. SLL 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Signature 
                 Scale 
                 UNIQID 
                 Unigene ID Build 167 
                 Probe set 
                 Gene Symbol 
               
               
                   
               
               
                 Standard 
                 −13.14 
                 1120765 
                 343329 
                 204484_at 
                 PIK3C2B 
               
               
                 Standard 
                 −12.9 
                 1097897 
                 266175 
                 225622_at 
                 PAG 
               
               
                 Standard 
                 12.72 
                 1133195 
                 274243 
                 205805_s_at 
                 ROR1 
               
               
                 Standard 
                 12.74 
                 1140416 
                 58831 
                 221601_s_at 
                 TOSO 
               
               
                 Standard 
                 13.53 
                 1131687 
                 369280 
                 202606_s_at 
                 TLK1 
               
               
                 Standard 
                 13.57 
                 1107044 
                 163426 
                 236458_at 
               
               
                 Standard 
                 14.43 
                 1529389 
                 79241 
                 Lymph_Dx_119_at 
                 BCL2 
               
               
                 Standard 
                 14.51 
                 1129026 
                 135146 
                 220007_at 
                 FLJ13984 
               
               
                 Standard 
                 14.77 
                 1136987 
                 21695 
                 213370_s_at 
                 SFMBT1 
               
               
                 Standard 
                 14.79 
                 1137109 
                 469653 
                 213689_x_at 
                 RPL5 
               
               
                 Standard 
                 15.37 
                 1529308 
                 193014 
                 Lymph_Dx_027_x_at 
               
               
                 Standard 
                 15.82 
                 1120832 
                 57856 
                 204604_at 
                 PFTK1 
               
               
                 Standard 
                 17.37 
                 1135550 
                 221811 
                 210550_s_at 
                 RASGRF1 
               
               
                 Standard 
                 18.98 
                 1122864 
                 434384 
                 208195_at 
                 TTN 
               
               
                 Lymph Node 
                 −12.89 
                 1123038 
                 119000 
                 208636_at 
                 ACTN1 
               
               
                 Lymph Node 
                 −12.8 
                 1130378 
                 234434 
                 44783_s_at 
                 HEY1 
               
               
                 Lymph Node 
                 −11.59 
                 1124875 
                 18166 
                 212975_at 
                 KIAA0870 
               
               
                 Lymph Node 
                 −11.47 
                 1103497 
                 50115 
                 232231_at 
               
               
                 Lymph Node 
                 −10.31 
                 1099358 
                 93135 
                 227300_at 
               
               
                 Lymph Node 
                 −10.27 
                 1121129 
                 285401 
                 205159_at 
                 CSF2RB 
               
               
                 Lymph Node 
                 −10.23 
                 1100249 
                 388674 
                 228367_at 
                 HAK 
               
               
                 Lymph Node 
                 −10.05 
                 1132345 
                 109225 
                 203868_s_at 
                 VCAM1 
               
               
                 Lymph Node 
                 −9.93 
                 1123401 
                 50130 
                 209550_at 
                 NDN 
               
               
                 Lymph Node 
                 −9.75 
                 1120500 
                 82568 
                 203979_at 
                 CYP27A1 
               
               
                 Lymph Node 
                 −9.57 
                 1124318 
                 21858 
                 212190_at 
                 SERPINE2 
               
               
                 Lymph Node 
                 −9.48 
                 1120288 
                 17483 
                 203547_at 
                 CD4 
               
               
                 Lymph Node 
                 −9.45 
                 1123372 
                 195825 
                 209487_at 
                 RBPMS 
               
               
                 Lymph Node 
                 −9.39 
                 1123376 
                 37682 
                 209496_at 
                 RARRES2 
               
               
                 Lymph Node 
                 −9.29 
                 1123213 
                 12956 
                 209154_at 
                 TIP-1 
               
               
                 Lymph Node 
                 −9.23 
                 1098412 
                 409515 
                 226225_at 
                 MCC 
               
               
                 Lymph Node 
                 −9.23 
                 1125593 
                 8910 
                 214180_at 
                 MAN1C1 
               
               
                 Lymph Node 
                 −9.17 
                 1131786 
                 375957 
                 202803_s_at 
                 ITGB2 
               
               
                 Lymph Node 
                 −9.04 
                 1097683 
                 132569 
                 225373_at 
                 PP2135 
               
               
                 Lymph Node 
                 −8.91 
                 1097255 
                 380144 
                 224861_at 
               
               
                 Lymph Node 
                 −8.76 
                 1131068 
                 118400 
                 201564_s_at 
                 FSCN1 
               
               
                 Lymph Node 
                 −8.7 
                 1119074 
                 54457 
                 200675_at 
                 CD81 
               
               
                 Lymph Node 
                 −8.68 
                 1125130 
                 35861 
                 213338_at 
                 RIS1 
               
               
                 Lymph Node 
                 −8.59 
                 1139661 
                 416456 
                 219806_s_at 
                 FN5 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                 Standard 
                 Lymph Node 
               
               
                   
                   
               
               
                   
                 Mean FH 
                 1144.02 
                 −2223.71 
                 Cut 1 
                 0.20 
               
               
                   
                 Mean SLL 
                 1592.27 
                 −1798.11 
                 Cut 2 
                 0.80 
               
               
                   
                 Covariance FH 
                 902.56 
                 442.69 
               
               
                   
                   
                 442.69 
                 809.90 
               
               
                   
                 Covariance SLL 
                 2426.26 
                 2938.58 
               
               
                   
                   
                 2938.58 
                 9435.72 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2408 
               
               
                   
               
               
                 FL vs. DLBCL-BL 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Signature 
                 Scale 
                 UNIQID 
                 Unigene ID Build 167 
                 Probe set 
                 Gene Symbol 
               
               
                   
               
               
                 Standard 
                 −23.03 
                 1124833 
                 356416 
                 212914_at 
                 CBX7 
               
               
                 Standard 
                 −22.25 
                 1099204 
                 193784 
                 227121_at 
               
               
                 Standard 
                 −22.2 
                 1119766 
                 93231 
                 202423_at 
                 MYST3 
               
               
                 Standard 
                 −22.04 
                 1099798 
                 411081 
                 227811_at 
                 FGD3 
               
               
                 Standard 
                 −22.01 
                 1102898 
                 145519 
                 231496_at 
                 FKSG87 
               
               
                 Standard 
                 −21.79 
                 1131197 
                 269902 
                 201778_s_at 
                 KIAA0494 
               
               
                 Standard 
                 −21.69 
                 1098415 
                 130900 
                 226230_at 
                 KIAA1387 
               
               
                 Standard 
                 −21.57 
                 1120834 
                 57907 
                 204606_at 
                 CCL21 
               
               
                 Standard 
                 −21.39 
                 1130155 
                 436657 
                 222043_at 
                 CLU 
               
               
                 Standard 
                 −20.98 
                 1100904 
                 426296 
                 229145_at 
                 LOC119504 
               
               
                 Standard 
                 −20.8 
                 1131531 
                 153647 
                 202350_s_at 
                 MATN2 
               
               
                 Standard 
                 −20.72 
                 1137582 
                 433732 
                 214683_s_at 
                 CLK1 
               
               
                 Standard 
                 −20.66 
                 1119782 
                 155418 
                 202478_at 
                 TRB2 
               
               
                 Standard 
                 −20.59 
                 1122767 
                 652 
                 207892_at 
                 TNFSF5 
               
               
                 Standard 
                 −20.58 
                 1125001 
                 16193 
                 213158_at 
               
               
                 Standard 
                 −20.56 
                 1134921 
                 413513 
                 209341_s_at 
                 IKBKB 
               
               
                 Standard 
                 −20.56 
                 1132973 
                 169294 
                 205255_x_at 
                 TCF7 
               
               
                 Standard 
                 −20.53 
                 1136984 
                 498154 
                 213364_s_at 
                 SNX1 
               
               
                 Standard 
                 −20.41 
                 1115888 
                 35096 
                 225629_s_at 
                 ZBTB4 
               
               
                 Standard 
                 −20.37 
                 1120160 
                 436976 
                 203288_at 
                 KIAA0355 
               
               
                 Standard 
                 −20.36 
                 1139054 
                 25726 
                 218263_s_at 
                 LOC58486 
               
               
                 Standard 
                 −20.31 
                 1130030 
                 301872 
                 221834_at 
                 LONP 
               
               
                 Standard 
                 −20.08 
                 1133024 
                 436987 
                 205383_s_at 
                 ZNF288 
               
               
                 Standard 
                 −20.05 
                 1124666 
                 526394 
                 212672_at 
                 ATM 
               
               
                 Standard 
                 −19.3 
                 1529397 
                 406557 
                 Lymph_Dx_127_s_at 
                 CLK4 
               
               
                 Standard 
                 −19.16 
                 1116056 
                 243678 
                 226913_s_at 
                 SOX8 
               
               
                 Standard 
                 −19.14 
                 1098433 
                 202577 
                 226250_at 
               
               
                 Standard 
                 −19.1 
                 1123635 
                 408614 
                 210073_at 
                 SIAT8A 
               
               
                 Standard 
                 −18.95 
                 1138920 
                 24395 
                 218002_s_at 
                 CXCL14 
               
               
                 Standard 
                 −18.84 
                 1133099 
                 88646 
                 205554_s_at 
                 DNASE1L3 
               
               
                 Standard 
                 −18.83 
                 1098495 
                 443668 
                 226318_at 
                 TBRG1 
               
               
                 Standard 
                 −18.64 
                 1100879 
                 119983 
                 229111_at 
                 MASP2 
               
               
                 Standard 
                 −18.59 
                 1120695 
                 385685 
                 204352_at 
                 TRAF5 
               
               
                 Standard 
                 −18.55 
                 1119983 
                 409783 
                 202920_at 
                 ANK2 
               
               
                 Standard 
                 −18.5 
                 1101276 
                 1098 
                 229588_at 
                 ERdj5 
               
               
                 Standard 
                 −18.47 
                 1099140 
                 500350 
                 227052_at 
               
               
                 Standard 
                 −18.46 
                 1529331 
                 374126 
                 Lymph_Dx_051_s_at 
               
               
                 Standard 
                 −18.45 
                 1131752 
                 170133 
                 202724_s_at 
                 FOXO1A 
               
               
                 Standard 
                 −18.45 
                 1099265 
                 375762 
                 227193_at 
               
               
                 Standard 
                 −18.32 
                 1098179 
                 163725 
                 225956_at 
                 LOC153222 
               
               
                 Standard 
                 −18.29 
                 1119568 
                 269777 
                 201957_at 
                 PPP1R12B 
               
               
                 Standard 
                 −18.19 
                 1099900 
                 444508 
                 227934_at 
               
               
                 Standard 
                 −18.17 
                 1119361 
                 391858 
                 201448_at 
                 TIA1 
               
               
                 Standard 
                 −18.02 
                 1121650 
                 421137 
                 206002_at 
                 GPR64 
               
               
                 Standard 
                 −17.91 
                 1100911 
                 320147 
                 229152_at 
                 C4orf7 
               
               
                 Standard 
                 −17.86 
                 1529285 
                 348929 
                 Lymph_Dx_002_at 
                 KIAA1219 
               
               
                 Standard 
                 −17.47 
                 1529357 
                 444651 
                 Lymph_Dx_081_at 
               
               
                 Standard 
                 −17.42 
                 1131863 
                 2316 
                 202936_s_at 
                 SOX9 
               
               
                 Standard 
                 −17.16 
                 1129943 
                 512828 
                 221626_at 
                 ZNF506 
               
               
                 Standard 
                 −17.12 
                 1121301 
                 449971 
                 205437_at 
                 ZNF134 
               
               
                 Standard 
                 −17.11 
                 1131340 
                 437457 
                 202018_s_at 
                 LTF 
               
               
                 Standard 
                 −17.1 
                 1124606 
                 444324 
                 212588_at 
                 PTPRC 
               
               
                 Standard 
                 −17.08 
                 1131407 
                 154248 
                 202125_s_at 
                 ALS2CR3 
               
               
                 Standard 
                 −16.97 
                 1118939 
                 198161 
                 60528_at 
                 PLA2G4B 
               
               
                 Standard 
                 −16.91 
                 1134738 
                 75842 
                 209033_s_at 
                 DYRK1A 
               
               
                 Standard 
                 −16.9 
                 1134083 
                 285091 
                 207996_s_at 
                 C18orf1 
               
               
                 Standard 
                 −16.89 
                 1120925 
                 204891 
                 204773_at 
                 IL11RA 
               
               
                 Standard 
                 −16.86 
                 1110070 
                 −101 
                 239803_at 
               
               
                 Standard 
                 −16.83 
                 1100042 
                 351413 
                 228113_at 
                 RAB37 
               
               
                 Standard 
                 −16.82 
                 1120134 
                 75545 
                 203233_at 
                 IL4R 
               
               
                 Standard 
                 −16.75 
                 1124283 
                 406612 
                 212144_at 
                 UNC84B 
               
               
                 Standard 
                 −16.72 
                 1109603 
                 −100 
                 239292_at 
               
               
                 Standard 
                 −16.71 
                 1120509 
                 155090 
                 204000_at 
                 GNB5 
               
               
                 Standard 
                 −16.65 
                 1133538 
                 1416 
                 206760_s_at 
                 FCER2 
               
               
                 Standard 
                 −16.64 
                 1130735 
                 179526 
                 201009_s_at 
                 TXNIP 
               
               
                 Standard 
                 −16.59 
                 1100150 
                 9343 
                 228248_at 
                 MGC39830 
               
               
                 Standard 
                 −16.54 
                 1124237 
                 258855 
                 212080_at 
                 MLL 
               
               
                 Standard 
                 −16.51 
                 1124416 
                 283604 
                 212331_at 
                 RBL2 
               
               
                 Standard 
                 −16.48 
                 1133091 
                 73792 
                 205544_s_at 
                 CR2 
               
               
                 Standard 
                 −16.46 
                 1131263 
                 249955 
                 201877_s_at 
                 PPP2R5C 
               
               
                 Standard 
                 −16.44 
                 1118347 
                 528404 
                 243366_s_at 
                 ITGA4 
               
               
                 Standard 
                 −16.43 
                 1529343 
                 521948 
                 Lymph_Dx_064_at 
               
               
                 Standard 
                 −16.43 
                 1099549 
                 446665 
                 227533_at 
               
               
                 Standard 
                 17.05 
                 1529453 
                 372679 
                 Lymph_Dx_085_at 
                 FCGR3A 
               
               
                 Standard 
                 17.41 
                 1097540 
                 388087 
                 225195_at 
               
               
                 Standard 
                 18.47 
                 1140473 
                 17377 
                 221676_s_at 
                 CORO1C 
               
               
                 Standard 
                 18.55 
                 1121100 
                 301921 
                 205098_at 
                 CCR1 
               
               
                 Standard 
                 20.07 
                 1124254 
                 301743 
                 212110_at 
                 SLC39A14 
               
               
                 Standard 
                 20.2 
                 1130771 
                 61153 
                 201068_s_at 
                 PSMC2 
               
               
                 Standard 
                 21.46 
                 1137583 
                 273415 
                 214687_x_at 
                 ALDOA 
               
               
                 Standard 
                 21.55 
                 1098168 
                 22151 
                 225943_at 
                 NLN 
               
               
                 Standard 
                 24.07 
                 1123055 
                 185726 
                 208691_at 
                 TFRC 
               
               
                 Standard 
                 24.09 
                 1123052 
                 180909 
                 208680_at 
                 PRDX1 
               
               
                 Lymph Node 
                 −20.5 
                 1137597 
                 3903 
                 214721_x_at 
                 CDC42EP4 
               
               
                 Lymph Node 
                 −18.52 
                 1124318 
                 21858 
                 212190_at 
                 SERPINE2 
               
               
                 Lymph Node 
                 −18.5 
                 1136762 
                 380138 
                 212624_s_at 
                 CHN1 
               
               
                 Lymph Node 
                 −18.07 
                 1101305 
                 112742 
                 229623_at 
               
               
                 Lymph Node 
                 −17.75 
                 1100249 
                 388674 
                 228367_at 
                 HAK 
               
               
                 Lymph Node 
                 −16.1 
                 1098412 
                 409515 
                 226225_at 
                 MCC 
               
               
                 Lymph Node 
                 −15.51 
                 1140464 
                 111676 
                 221667_s_at 
                 HSPB8 
               
               
                 Lymph Node 
                 −15.43 
                 1136832 
                 434959 
                 212842_x_at 
                 RANBP2L1 
               
               
                 Lymph Node 
                 −15.37 
                 1119684 
                 439586 
                 202242_at 
                 TM4SF2 
               
               
                 Lymph Node 
                 −15.02 
                 1097448 
                 250607 
                 225093_at 
                 UTRN 
               
               
                 Lymph Node 
                 −14.83 
                 1136844 
                 16007 
                 212875_s_at 
                 C21orf25 
               
               
                 Lymph Node 
                 −14.73 
                 1135056 
                 169946 
                 209604_s_at 
                 GATA3 
               
               
                 Lymph Node 
                 −14.48 
                 1097202 
                 386779 
                 224796_at 
                 DDEF1 
               
               
                 Lymph Node 
                 −14.44 
                 1121278 
                 21355 
                 205399_at 
                 DCAMKL1 
               
               
                 Lymph Node 
                 −14.22 
                 1125009 
                 27621 
                 213169_at 
               
               
                 Lymph Node 
                 −13.97 
                 1100288 
                 26981 
                 228411_at 
                 ALS2CR19 
               
               
                 Lymph Node 
                 −13.51 
                 1132462 
                 14845 
                 204131_s_at 
                 FOXO3A 
               
               
                 Lymph Node 
                 −13.37 
                 1135322 
                 450230 
                 210095_s_at 
                 IGFBP3 
               
               
                 Lymph Node 
                 −13.35 
                 1097280 
                 423523 
                 224891_at 
               
               
                 Lymph Node 
                 −12.86 
                 1137097 
                 20107 
                 213656_s_at 
                 KNS2 
               
               
                 Lymph Node 
                 −12.85 
                 1098809 
                 359394 
                 226682_at 
               
               
                 Lymph Node 
                 −12.28 
                 1124875 
                 18166 
                 212975_at 
                 KIAA0870 
               
               
                 Lymph Node 
                 −12.18 
                 1132345 
                 109225 
                 203868_s_at 
                 VCAM1 
               
               
                 Lymph Node 
                 −12 
                 1097561 
                 19221 
                 225224_at 
                 DKFZP566G1424 
               
               
                 Lymph Node 
                 −11.71 
                 1123401 
                 50130 
                 209550_at 
                 NDN 
               
               
                 Lymph Node 
                 −11.04 
                 1136996 
                 283749 
                 213397_x_at 
                 RNASE4 
               
               
                 Lymph Node 
                 −10.77 
                 1136788 
                 355455 
                 212698_s_at 
                 36778 
               
               
                 Lymph Node 
                 −10.71 
                 1098822 
                 443452 
                 226695_at 
                 PRRX1 
               
               
                 Lymph Node 
                 −10.63 
                 1134200 
                 90786 
                 208161_s_at 
                 ABCC3 
               
               
                 Lymph Node 
                 −10.47 
                 1136427 
                 276506 
                 211795_s_at 
                 FYB 
               
               
                 Lymph Node 
                 −10.46 
                 1121186 
                 100431 
                 205242_at 
                 CXCL13 
               
               
                 Lymph Node 
                 −10.39 
                 1099332 
                 32433 
                 227272_at 
               
               
                 Lymph Node 
                 −10.39 
                 1098978 
                 124863 
                 226869_at 
               
               
                 Lymph Node 
                 −10.22 
                 1103303 
                 49605 
                 232000_at 
                 C9orf52 
               
               
                 Lymph Node 
                 −10.16 
                 1131325 
                 13313 
                 201990_s_at 
                 CREBL2 
               
               
                 Lymph Node 
                 −10.16 
                 1098174 
                 274401 
                 225949_at 
                 LOC340371 
               
               
                 Lymph Node 
                 −9.93 
                 1124733 
                 66762 
                 212771_at 
                 LOC221061 
               
               
                 Lymph Node 
                 −9.42 
                 1123372 
                 195825 
                 209487_at 
                 RBPMS 
               
               
                 Lymph Node 
                 −9.36 
                 1132220 
                 448805 
                 203632_s_at 
                 GPRC5B 
               
               
                 Lymph Node 
                 −9.29 
                 1120703 
                 83974 
                 204368_at 
                 SLCO2A1 
               
               
                 Lymph Node 
                 −9.26 
                 1132013 
                 434961 
                 203232_s_at 
                 SCA1 
               
               
                 Lymph Node 
                 −9.25 
                 1097307 
                 379754 
                 224929_at 
                 LOC340061 
               
               
                 Lymph Node 
                 −9.18 
                 1119251 
                 433941 
                 201194_at 
                 SEPW1 
               
               
                 Lymph Node 
                 −9.08 
                 1097609 
                 6093 
                 225283_at 
                 ARRDC4 
               
               
                 Lymph Node 
                 −9.07 
                 1136459 
                 252550 
                 211828_s_at 
                 KIAA0551 
               
               
                 Lymph Node 
                 −8.86 
                 1132775 
                 1027 
                 204803_s_at 
                 RRAD 
               
               
                 Lymph Node 
                 −8.78 
                 1098946 
                 135121 
                 226834_at 
                 ASAM 
               
               
                 Lymph Node 
                 −8.68 
                 1140589 
                 433488 
                 221942_s_at 
                 GUCY1A3 
               
               
                 Lymph Node 
                 −8.44 
                 1116966 
                 301124 
                 232744_x_at 
               
               
                 Lymph Node 
                 −8.39 
                 1100130 
                 76494 
                 228224_at 
                 PRELP 
               
               
                 Lymph Node 
                 −8.36 
                 1110019 
                 −94 
                 239744_at 
               
               
                 Lymph Node 
                 −8.3 
                 1134647 
                 298654 
                 208892_s_at 
                 DUSP6 
               
               
                 Lymph Node 
                 −8.28 
                 1125593 
                 8910 
                 214180_at 
                 MAN1C1 
               
               
                 Lymph Node 
                 7.97 
                 1134370 
                 1422 
                 208438_s_at 
                 FGR 
               
               
                 Lymph Node 
                 8.05 
                 1123566 
                 155935 
                 209906_at 
                 C3AR1 
               
               
                 Lymph Node 
                 8.09 
                 1131119 
                 349656 
                 201647_s_at 
                 SCARB2 
               
               
                 Lymph Node 
                 8.11 
                 1123586 
                 93841 
                 209948_at 
                 KCNMB1 
               
               
                 Lymph Node 
                 8.13 
                 1128615 
                 104800 
                 219410_at 
                 FLJ10134 
               
               
                 Lymph Node 
                 8.21 
                 1097297 
                 166254 
                 224917_at 
                 VMP1 
               
               
                 Lymph Node 
                 8.23 
                 1120299 
                 79334 
                 203574_at 
                 NFIL3 
               
               
                 Lymph Node 
                 8.37 
                 1128157 
                 23918 
                 218631_at 
                 VIP32 
               
               
                 Lymph Node 
                 8.4 
                 1130054 
                 82547 
                 221872_at 
                 RARRES1 
               
               
                 Lymph Node 
                 8.41 
                 1098152 
                 377588 
                 225922_at 
                 KIAA1450 
               
               
                 Lymph Node 
                 8.53 
                 1101566 
                 98558 
                 229947_at 
               
               
                 Lymph Node 
                 8.59 
                 1135251 
                 21486 
                 209969_s_at 
                 STAT1 
               
               
                 Lymph Node 
                 8.84 
                 1099167 
                 381105 
                 227080_at 
                 MGC45731 
               
               
                 Lymph Node 
                 9.01 
                 1132920 
                 753 
                 205119_s_at 
                 FPR1 
               
               
                 Lymph Node 
                 9.26 
                 1097253 
                 77873 
                 224859_at 
                 B7H3 
               
               
                 Lymph Node 
                 9.29 
                 1120500 
                 82568 
                 203979_at 
                 CYP27A1 
               
               
                 Lymph Node 
                 9.36 
                 1131507 
                 172928 
                 202311_s_at 
                 COL1A1 
               
               
                 Lymph Node 
                 9.38 
                 1096456 
                 82407 
                 223454_at 
                 CXCL16 
               
               
                 Lymph Node 
                 9.49 
                 1136172 
                 38084 
                 211470_s_at 
                 SULT1C1 
               
               
                 Lymph Node 
                 10.03 
                 1138244 
                 418138 
                 216442_x_at 
                 FN1 
               
               
                 Lymph Node 
                 10.34 
                 1134424 
                 −17 
                 208540_x_at 
                 S100A14 
               
               
                 Lymph Node 
                 10.48 
                 1136152 
                 458436 
                 211434_s_at 
                 CCRL2 
               
               
                 Lymph Node 
                 10.51 
                 1118708 
                 7835 
                 37408_at 
                 MRC2 
               
               
                 Lymph Node 
                 10.6 
                 1136540 
                 179657 
                 211924_s_at 
                 PLAUR 
               
               
                 Lymph Node 
                 10.63 
                 1098278 
                 166017 
                 226066_at 
                 MITF 
               
               
                 Lymph Node 
                 10.76 
                 1119477 
                 163867 
                 201743_at 
                 CD14 
               
               
                 Lymph Node 
                 10.81 
                 1096429 
                 64896 
                 223405_at 
                 NPL 
               
               
                 Lymph Node 
                 11.58 
                 1123672 
                 67846 
                 210152_at 
                 LILRB4 
               
               
                 Lymph Node 
                 12 
                 1096364 
                 29444 
                 223276_at 
                 NID67 
               
               
                 Lymph Node 
                 12.16 
                 1119070 
                 445570 
                 200663_at 
                 CD63 
               
               
                 Lymph Node 
                 12.3 
                 1133065 
                 77274 
                 205479_s_at 
                 PLAU 
               
               
                 Lymph Node 
                 12.5 
                 1135240 
                 436852 
                 209955_s_at 
                 FAP 
               
               
                 Lymph Node 
                 13.09 
                 1116826 
                 26204 
                 231823_s_at 
                 KIAA1295 
               
               
                 Lymph Node 
                 13.32 
                 1119068 
                 417004 
                 200660_at 
                 S100A11 
               
               
                 Lymph Node 
                 13.45 
                 1120266 
                 246381 
                 203507_at 
                 CD68 
               
               
                 Lymph Node 
                 13.63 
                 1133216 
                 502577 
                 205872_x_at 
                 PDE4DIP 
               
               
                 Lymph Node 
                 13.67 
                 1131815 
                 386678 
                 202856_s_at 
                 SLC16A3 
               
               
                 Lymph Node 
                 14.38 
                 1132132 
                 279910 
                 203454_s_at 
                 ATOX1 
               
               
                 Lymph Node 
                 15.25 
                 1134682 
                 411701 
                 208949_s_at 
                 LGALS3 
               
               
                 Lymph Node 
                 15.46 
                 1119237 
                 389964 
                 201141_at 
                 GPNMB 
               
               
                 Lymph Node 
                 15.89 
                 1137698 
                 442669 
                 215001_s_at 
                 GLUL 
               
               
                 Lymph Node 
                 17.8 
                 1137782 
                 384944 
                 215223_s_at 
                 SOD2 
               
               
                 Lymph Node 
                 20.11 
                 1130629 
                 135226 
                 200839_s_at 
                 CTSB 
               
               
                 Proliferation 
                 21.02 
                 1119375 
                 381072 
                 201489_at 
                 PPIF 
               
               
                 Proliferation 
                 21.24 
                 1119488 
                 154672 
                 201761_at 
                 MTHFD2 
               
               
                 Proliferation 
                 21.31 
                 1119467 
                 21635 
                 201714_at 
                 TUBG1 
               
               
                 Proliferation 
                 21.68 
                 1130820 
                 151777 
                 201144_s_at 
                 EIF2S1 
               
               
                 Proliferation 
                 21.69 
                 1131474 
                 95577 
                 202246_s_at 
                 CDK4 
               
               
                 Proliferation 
                 22.2 
                 1125249 
                 244723 
                 213523_at 
                 CCNE1 
               
               
                 Proliferation 
                 22.97 
                 1130501 
                 2795 
                 200650_s_at 
                 LDHA 
               
               
                 Proliferation 
                 23.12 
                 1136913 
                 99962 
                 213113_s_at 
                 SLC43A3 
               
               
                 Proliferation 
                 24.05 
                 1130426 
                 432607 
                 200039_s_at 
                 PSMB2 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                 Standard 
                 Lymph Node 
                 Proliferation 
               
               
                   
                   
               
               
                   
                 Mean FL 
                 −11121.51 
                 −1603.39 
                 1890.60 
                 Cut 1 
                 0.34 
               
               
                   
                 Mean DLBCL-BL 
                 −8760.65 
                 −460.71 
                 2101.10 
                 Cut 2 
                 0.94 
               
               
                   
                 Covariance FL 
                 246359.77 
                 111505.42 
                 28908.20 
               
               
                   
                   
                 111505.42 
                 67036.17 
                 13130.59 
               
               
                   
                   
                 28908.20 
                 13130.59 
                 4617.24 
               
               
                   
                 Covariance DLBCL-BL 
                 413069.12 
                 178811.32 
                 30151.89 
               
               
                   
                   
                 178811.32 
                 106324.53 
                 10877.26 
               
               
                   
                   
                 30151.89 
                 10877.26 
                 5180.68 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2409 
               
               
                   
               
               
                 FL vs. MCL 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Signature 
                 Scale 
                 UNIQID 
                 Unigene ID Build 167 
                 Probe set 
                 Gene Symbol 
               
               
                   
               
               
                 Standard 
                 −24.56 
                 1123731 
                 17165 
                 210258_at 
                 RGS13 
               
               
                 Standard 
                 −22.56 
                 1133192 
                 24024 
                 205801_s_at 
                 RASGRP3 
               
               
                 Standard 
                 −21.12 
                 1114543 
                 156189 
                 244887_at 
               
               
                 Standard 
                 −18.49 
                 1120090 
                 155024 
                 203140_at 
                 BCL6 
               
               
                 Standard 
                 −18.07 
                 1124646 
                 436432 
                 212646_at 
                 RAFTLIN 
               
               
                 Standard 
                 −17.24 
                 1132122 
                 307734 
                 203434_s_at 
                 MME 
               
               
                 Standard 
                 −16.63 
                 1105986 
                 49614 
                 235310_at 
                 GCET2 
               
               
                 Standard 
                 −15.09 
                 1120134 
                 75545 
                 203233_at 
                 IL4R 
               
               
                 Standard 
                 −14.05 
                 1132651 
                 439767 
                 204529_s_at 
                 TOX 
               
               
                 Standard 
                 13.8 
                 1098277 
                 6786 
                 226065_at 
                 PRICKLE1 
               
               
                 Standard 
                 13.85 
                 1109560 
                 207428 
                 239246_at 
                 FARP1 
               
               
                 Standard 
                 13.86 
                 1103504 
                 142517 
                 232239_at 
               
               
                 Standard 
                 13.88 
                 1132734 
                 126248 
                 204724_s_at 
                 COL9A3 
               
               
                 Standard 
                 13.91 
                 1115905 
                 301478 
                 225757_s_at 
                 CLMN 
               
               
                 Standard 
                 14.89 
                 1098840 
                 55098 
                 226713_at 
                 C3orf6 
               
               
                 Standard 
                 14.97 
                 1100873 
                 445884 
                 229103_at 
               
               
                 Standard 
                 14.99 
                 1139393 
                 170129 
                 219032_x_at 
                 OPN3 
               
               
                 Standard 
                 16.13 
                 1124864 
                 411317 
                 212960_at 
                 KIAA0882 
               
               
                 Standard 
                 16.36 
                 1106855 
                 455101 
                 236255_at 
                 KIAA1909 
               
               
                 Standard 
                 16.43 
                 1120858 
                 410683 
                 204647_at 
                 HOMER3 
               
               
                 Standard 
                 17.38 
                 1130926 
                 508741 
                 201310_s_at 
                 C5orf13 
               
               
                 Standard 
                 18.3 
                 1103711 
                 288718 
                 232478_at 
               
               
                 Standard 
                 18.62 
                 1109505 
                 8162 
                 239186_at 
                 MGC39372 
               
               
                 Standard 
                 20.31 
                 1132834 
                 432638 
                 204914_s_at 
                 SOX11 
               
               
                 Standard 
                 22.61 
                 1096070 
                 241565 
                 222640_at 
                 DNMT3A 
               
               
                 Standard 
                 28.66 
                 1529382 
                 371468 
                 Lymph_Dx_111_at 
                 CCND1 
               
               
                 Lymph Node 
                 −10.77 
                 1097202 
                 386779 
                 224796_at 
                 DDEF1 
               
               
                 Lymph Node 
                 −10.22 
                 1119546 
                 433898 
                 201921_at 
                 GNG10 
               
               
                 Lymph Node 
                 −9.89 
                 1132766 
                 82359 
                 204781_s_at 
                 TNFRSF6 
               
               
                 Lymph Node 
                 −9.4 
                 1138867 
                 10706 
                 217892_s_at 
                 EPLIN 
               
               
                 Lymph Node 
                 9.65 
                 1125025 
                 301094 
                 213196_at 
               
               
                 Lymph Node 
                 10.44 
                 1134797 
                 433394 
                 209118_s_at 
                 TUBA3 
               
               
                 Lymph Node 
                 22.6 
                 1529456 
                 371468 
                 Lymph_Dx_113_at 
                 CCND1 
               
               
                 Proliferation 
                 −7.36 
                 1097948 
                 69476 
                 225684_at 
                 LOC348235 
               
               
                 Proliferation 
                 −7.31 
                 1130747 
                 234489 
                 201030_x_at 
                 LDHB 
               
               
                 Proliferation 
                 −6.95 
                 1130923 
                 459987 
                 201306_s_at 
                 ANP32B 
               
               
                 Proliferation 
                 −6.87 
                 1120205 
                 5198 
                 203405_at 
                 DSCR2 
               
               
                 Proliferation 
                 −6.64 
                 1132468 
                 79353 
                 204147_s_at 
                 TFDP1 
               
               
                 Proliferation 
                 −6.1 
                 1119916 
                 177584 
                 202780_at 
                 OXCT 
               
               
                 Proliferation 
                 −6.08 
                 1119873 
                 446393 
                 202697_at 
                 CPSF5 
               
               
                 Proliferation 
                 −6.08 
                 1119488 
                 154672 
                 201761_at 
                 MTHFD2 
               
               
                 Proliferation 
                 −6.04 
                 1130658 
                 447492 
                 200886_s_at 
                 PGAM1 
               
               
                 Proliferation 
                 −5.82 
                 1132825 
                 512813 
                 204900_x_at 
                 SAP30 
               
               
                 Proliferation 
                 −5.53 
                 1115607 
                 435733 
                 224428_s_at 
                 CDCA7 
               
               
                 Proliferation 
                 −5.44 
                 1120316 
                 63335 
                 203611_at 
                 TERF2 
               
               
                 Proliferation 
                 −5.34 
                 1114970 
                 279529 
                 223032_x_at 
                 PX19 
               
               
                 Proliferation 
                 −5.32 
                 1140843 
                 169476 
                 AFFX- 
                 GAPD 
               
               
                   
                   
                   
                   
                 HUMGAPDH/M 
               
               
                   
                   
                   
                   
                 33197_5_at 
               
               
                 Proliferation 
                 −5.28 
                 1131081 
                 180610 
                 201586_s_at 
                 SFPQ 
               
               
                 Proliferation 
                 −5.15 
                 1121062 
                 408658 
                 205034_at 
                 CCNE2 
               
               
                 Proliferation 
                 5.15 
                 1120986 
                 172052 
                 204886_at 
                 PLK4 
               
               
                 Proliferation 
                 5.16 
                 1097195 
                 149931 
                 224785_at 
                 MGC29814 
               
               
                 Proliferation 
                 5.2 
                 1120011 
                 3068 
                 202983_at 
                 SMARCA3 
               
               
                 Proliferation 
                 5.47 
                 1100183 
                 180582 
                 228286_at 
                 FLJ40869 
               
               
                 Proliferation 
                 5.67 
                 1121012 
                 96055 
                 204947_at 
                 E2F1 
               
               
                 Proliferation 
                 5.84 
                 1115679 
                 8345 
                 224523_s_at 
                 MGC4308 
               
               
                 Proliferation 
                 5.88 
                 1135285 
                 449501 
                 210024_s_at 
                 UBE2E3 
               
               
                 Proliferation 
                 5.92 
                 1120520 
                 35120 
                 204023_at 
                 RFC4 
               
               
                 Proliferation 
                 6.16 
                 1529361 
                 388681 
                 Lymph_Dx_086_s_at 
                 HDAC3 
               
               
                 Proliferation 
                 6.45 
                 1096054 
                 21331 
                 222606_at 
                 FLJ10036 
               
               
                 Proliferation 
                 6.45 
                 1096738 
                 87968 
                 223903_at 
                 TLR9 
               
               
                 Proliferation 
                 6.51 
                 1136781 
                 120197 
                 212680_x_at 
                 PPP1R14B 
               
               
                 Proliferation 
                 6.63 
                 1119466 
                 179718 
                 201710_at 
                 MYBL2 
               
               
                 Proliferation 
                 6.65 
                 1136285 
                 182490 
                 211615_s_at 
                 LRPPRC 
               
               
                 Proliferation 
                 6.67 
                 1136853 
                 66170 
                 212922_s_at 
                 SMYD2 
               
               
                 Proliferation 
                 7.45 
                 1119390 
                 77254 
                 201518_at 
                 CBX1 
               
               
                 Proliferation 
                 8.87 
                 1116122 
                 42768 
                 227408_s_at 
                 DKFZp761O0113 
               
               
                 Proliferation 
                 10.12 
                 1119515 
                 3352 
                 201833_at 
                 HDAC2 
               
               
                   
               
            
           
           
               
               
               
               
               
               
               
            
               
                   
                   
                 Standard 
                 Lymph Node 
                 Proliferation 
               
               
                   
                   
               
               
                   
                 Mean FL 
                 −18.82 
                 −33.90 
                 23.53 
                 Cut 1 
                 0.14 
               
               
                   
                 Mean MCL 
                 1558.10 
                 113.95 
                 165.48 
                 Cut 2 
                 0.58 
               
               
                   
                 Covariance FL 
                 21302.14 
                 1098.24 
                 678.04 
               
               
                   
                   
                 1098.24 
                 226.29 
                 75.99 
               
               
                   
                   
                 678.04 
                 75.99 
                 315.67 
               
               
                   
                 Covariance MCL 
                 81008.29 
                 5261.37 
                 9185.20 
               
               
                   
                   
                 5261.37 
                 2047.34 
                 875.56 
               
               
                   
                   
                 9185.20 
                 875.56 
                 1447.43 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2410 
               
               
                   
               
               
                 FL vs. SLL 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Signature 
                 Scale 
                 UNIQID 
                 Unigene ID Build 167 
                 Probe set 
                 Gene Symbol 
               
               
                   
               
               
                 Standard 
                 −21.04 
                 1123731 
                 17165 
                 210258_at 
                 RGS13 
               
               
                 Standard 
                 −20.91 
                 1124646 
                 436432 
                 212646_at 
                 RAFTLIN 
               
               
                 Standard 
                 −18.82 
                 1099651 
                 120785 
                 227646_at 
                 EBF 
               
               
                 Standard 
                 −18.12 
                 1114543 
                 156189 
                 244887_at 
               
               
                 Standard 
                 −17.85 
                 1105986 
                 49614 
                 235310_at 
                 GCET2 
               
               
                 Standard 
                 −16.73 
                 1100911 
                 320147 
                 229152_at 
                 C4orf7 
               
               
                 Standard 
                 −15.77 
                 1132122 
                 307734 
                 203434_s_at 
                 MME 
               
               
                 Standard 
                 −15.12 
                 1120090 
                 155024 
                 203140_at 
                 BCL6 
               
               
                 Standard 
                 −14.89 
                 1097897 
                 266175 
                 225622_at 
                 PAG 
               
               
                 Standard 
                 −14.36 
                 1529343 
                 521948 
                 Lymph_Dx_064_at 
               
               
                 Standard 
                 −14.32 
                 1529318 
                 291954 
                 Lymph_Dx_038_at 
               
               
                 Standard 
                 −14.06 
                 1128694 
                 171466 
                 219517_at 
                 ELL3 
               
               
                 Standard 
                 −13.61 
                 1101586 
                 187884 
                 229971_at 
                 GPR114 
               
               
                 Standard 
                 −13.57 
                 1119752 
                 511745 
                 202391_at 
                 BASP1 
               
               
                 Standard 
                 −13.13 
                 1137561 
                 67397 
                 214639_s_at 
                 HOXA1 
               
               
                 Standard 
                 −12.85 
                 1097247 
                 388761 
                 224851_at 
                 CDK6 
               
               
                 Standard 
                 −12.43 
                 1529344 
                 317970 
                 Lymph_Dx_065_at 
                 SERPINA11 
               
               
                 Standard 
                 −12.4 
                 1120765 
                 343329 
                 204484_at 
                 PIK3C2B 
               
               
                 Standard 
                 −12.33 
                 1130155 
                 436657 
                 222043_at 
                 CLU 
               
               
                 Standard 
                 −12.07 
                 1529292 
                 −92 
                 Lymph_Dx_010_at 
               
               
                 Standard 
                 −12.01 
                 1119939 
                 170087 
                 202820_at 
                 AHR 
               
               
                 Standard 
                 −11.82 
                 1119919 
                 199263 
                 202786_at 
                 STK39 
               
               
                 Standard 
                 −11.77 
                 1099686 
                 117721 
                 227684_at 
               
               
                 Standard 
                 −11.63 
                 1119782 
                 155418 
                 202478_at 
                 TRB2 
               
               
                 Standard 
                 10.97 
                 1529309 
                 512797 
                 Lymph_Dx_028_at 
                 HSH2 
               
               
                 Standard 
                 10.97 
                 1139393 
                 170129 
                 219032_x_at 
                 OPN3 
               
               
                 Standard 
                 11.04 
                 1131246 
                 153752 
                 201853_s_at 
                 CDC25B 
               
               
                 Standard 
                 11.07 
                 1140391 
                 44865 
                 221558_s_at 
                 LEF1 
               
               
                 Standard 
                 11.16 
                 1140416 
                 58831 
                 221601_s_at 
                 TOSO 
               
               
                 Standard 
                 11.35 
                 1127807 
                 7236 
                 217950_at 
                 NOSIP 
               
               
                 Standard 
                 11.67 
                 1529317 
                 −98 
                 Lymph_Dx_037_at 
               
               
                 Standard 
                 11.81 
                 1117343 
                 306812 
                 234643_x_at 
                 BUCS1 
               
               
                 Standard 
                 11.82 
                 1102081 
                 506977 
                 230551_at 
               
               
                 Standard 
                 11.82 
                 1135042 
                 79015 
                 209582_s_at 
                 MOX2 
               
               
                 Standard 
                 11.96 
                 1132734 
                 126248 
                 204724_s_at 
                 COL9A3 
               
               
                 Standard 
                 12.09 
                 1137109 
                 469653 
                 213689_x_at 
                 RPL5 
               
               
                 Standard 
                 12.14 
                 1099939 
                 488173 
                 227983_at 
                 MGC7036 
               
               
                 Standard 
                 12.19 
                 1129103 
                 99430 
                 220118_at 
                 TZFP 
               
               
                 Standard 
                 12.47 
                 1135592 
                 758 
                 210621_s_at 
                 RASA1 
               
               
                 Standard 
                 12.78 
                 1108970 
                 140489 
                 238604_at 
               
               
                 Standard 
                 12.92 
                 1097143 
                 74335 
                 224716_at 
                 HSPCB 
               
               
                 Standard 
                 13.18 
                 1136865 
                 412128 
                 212959_s_at 
                 MGC4170 
               
               
                 Standard 
                 13.96 
                 1098220 
                 80720 
                 226002_at 
                 GAB1 
               
               
                 Standard 
                 14.06 
                 1100847 
                 97411 
                 229070_at 
                 C6orf105 
               
               
                 Standard 
                 14.39 
                 1098865 
                 250905 
                 226741_at 
                 LOC51234 
               
               
                 Standard 
                 15.57 
                 1136687 
                 59943 
                 212345_s_at 
                 CREB3L2 
               
               
                 Standard 
                 15.75 
                 1107044 
                 163426 
                 236458_at 
               
               
                 Standard 
                 16.52 
                 1123622 
                 8578 
                 210051_at 
                 EPAC 
               
               
                 Standard 
                 17.74 
                 1136987 
                 21695 
                 213370_s_at 
                 SFMBT1 
               
               
                 Standard 
                 19.15 
                 1129026 
                 135146 
                 220007_at 
                 FLJ13984 
               
               
                 Standard 
                 19.65 
                 1131854 
                 414985 
                 202923_s_at 
                 GCLC 
               
               
                 Lymph Node 
                 −14.99 
                 1124875 
                 18166 
                 212975_at 
                 KIAA0870 
               
               
                 Lymph Node 
                 −14.33 
                 1099358 
                 93135 
                 227300_at 
               
               
                 Lymph Node 
                 −13.26 
                 1121129 
                 285401 
                 205159_at 
                 CSF2RB 
               
               
                 Lymph Node 
                 −12.61 
                 1119074 
                 54457 
                 200675_at 
                 CD81 
               
               
                 Lymph Node 
                 −12.52 
                 1121029 
                 412999 
                 204971_at 
                 CSTA 
               
               
                 Lymph Node 
                 −11.48 
                 1137247 
                 234734 
                 213975_s_at 
                 LYZ 
               
               
                 Lymph Node 
                 −10.97 
                 1128781 
                 79741 
                 219648_at 
                 FLJ10116 
               
               
                 Lymph Node 
                 11.79 
                 1119880 
                 442844 
                 202709_at 
                 FMOD 
               
               
                 Lymph Node 
                 14.4 
                 1134370 
                 1422 
                 208438_s_at 
                 FGR 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                 Standard 
                 Lymph Node 
               
               
                   
                   
               
               
                   
                 Mean FL 
                 −663.95 
                 −730.08 
                 Cut 1 
                 0.20 
               
               
                   
                 Mean SLL 
                 1332.84 
                 −484.93 
                 Cut 2 
                 0.80 
               
               
                   
                 Covariance FL 
                 37097.15 
                 1710.73 
               
               
                   
                   
                 1710.73 
                 663.78 
               
               
                   
                 Covariance SLL 
                 85989.25 
                 17661.52 
               
               
                   
                   
                 17661.52 
                 4555.06 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2411 
               
               
                   
               
               
                 GCB vs. PMBL 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Signature 
                 Scale 
                 UNIQID 
                 Unigene ID Build 167 
                 Probe set 
                 Gene Symbol 
               
               
                   
               
               
                 Standard 
                 −8.39 
                 1096440 
                 231320 
                 223423_at 
                 GPR160 
               
               
                 Standard 
                 −8.13 
                 1096108 
                 292871 
                 222731_at 
                 ZDHHC2 
               
               
                 Standard 
                 −8.12 
                 1125231 
                 446375 
                 213489_at 
                 MAPRE2 
               
               
                 Standard 
                 −8.02 
                 1136759 
                 188882 
                 212605_s_at 
               
               
                 Standard 
                 −7.91 
                 1096499 
                 293867 
                 223514_at 
                 CARD11 
               
               
                 Standard 
                 −7.8 
                 1099388 
                 124024 
                 227336_at 
                 DTX1 
               
               
                 Standard 
                 −7.71 
                 1139623 
                 193736 
                 219667_s_at 
                 BANK1 
               
               
                 Standard 
                 −7.68 
                 1098592 
                 283707 
                 226431_at 
                 ALS2CR13 
               
               
                 Standard 
                 −7.67 
                 1107575 
                 424589 
                 237033_at 
                 MGC52498 
               
               
                 Standard 
                 −7.63 
                 1116829 
                 115467 
                 231840_x_at 
                 LOC90624 
               
               
                 Standard 
                 −7.42 
                 1130114 
                 445084 
                 221965_at 
                 MPHOSPH9 
               
               
                 Standard 
                 −7.27 
                 1098909 
                 446408 
                 226789_at 
               
               
                 Standard 
                 7.34 
                 1138759 
                 396404 
                 217707_x_at 
                 SMARCA2 
               
               
                 Standard 
                 7.37 
                 1120355 
                 80420 
                 203687_at 
                 CX3CL1 
               
               
                 Standard 
                 7.4 
                 1134270 
                 352119 
                 208284_x_at 
                 GGT1 
               
               
                 Standard 
                 7.44 
                 1115441 
                 5470 
                 224156_x_at 
                 IL17RB 
               
               
                 Standard 
                 7.78 
                 1103054 
                 341531 
                 231690_at 
               
               
                 Standard 
                 7.91 
                 1119765 
                 81234 
                 202421_at 
                 IGSF3 
               
               
                 Standard 
                 7.92 
                 1119438 
                 118110 
                 201641_at 
                 BST2 
               
               
                 Standard 
                 8.09 
                 1135645 
                 31439 
                 210715_s_at 
                 SPINT2 
               
               
                 Standard 
                 8.15 
                 1106015 
                 96885 
                 235343_at 
                 FLJ12505 
               
               
                 Standard 
                 8.18 
                 1121400 
                 223474 
                 205599_at 
                 TRAF1 
               
               
                 Standard 
                 8.38 
                 1139950 
                 437385 
                 220731_s_at 
                 FLJ10420 
               
               
                 Standard 
                 8.73 
                 1122112 
                 1314 
                 206729_at 
                 TNFRSF8 
               
               
                 Standard 
                 8.77 
                 1122772 
                 66742 
                 207900_at 
                 CCL17 
               
               
                 Standard 
                 8.84 
                 1132762 
                 80395 
                 204777_s_at 
                 MAL 
               
               
                 Standard 
                 9.64 
                 1139774 
                 15827 
                 220140_s_at 
                 SNX11 
               
               
                 Standard 
                 10.53 
                 1133801 
                 181097 
                 207426_s_at 
                 TNFSF4 
               
               
                 Standard 
                 11.52 
                 1106415 
                 169071 
                 235774_at 
               
               
                 Standard 
                 12.09 
                 1129269 
                 62919 
                 220358_at 
                 SNFT 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                 Standard 
               
               
                   
                   
               
               
                   
                 Mean GCB 
                 292.76 
                 Cut 1 
                 0.16 
               
               
                   
                 Mean PMBL 
                 725.28 
                 Cut 2 
                 0.50 
               
               
                   
                 Covariance GCB 
                 8538.86 
               
               
                   
                 Covariance PMBL 
                 11405.23 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2412 
               
               
                   
               
               
                 MCL vs. DLBCL-BL 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Signature 
                 Scale 
                 UNIQID 
                 Unigene ID Build 167 
                 Probe set 
                 Gene Symbol 
               
               
                   
               
               
                 Standard 
                 −26.11 
                 1529382 
                 371468 
                 Lymph_Dx_111_at 
                 CCND1 
               
               
                 Standard 
                 −18.35 
                 1103711 
                 288718 
                 232478_at 
               
               
                 Standard 
                 −17.03 
                 1106855 
                 455101 
                 236255_at 
                 KIAA1909 
               
               
                 Standard 
                 −16.49 
                 1098840 
                 55098 
                 226713_at 
                 C3orf6 
               
               
                 Standard 
                 −15.41 
                 1109505 
                 8162 
                 239186_at 
                 MGC39372 
               
               
                 Standard 
                 −15.11 
                 1098954 
                 128905 
                 226844_at 
                 MOBKL2B 
               
               
                 Standard 
                 −14.96 
                 1103504 
                 142517 
                 232239_at 
               
               
                 Standard 
                 −14.74 
                 1096070 
                 241565 
                 222640_at 
                 DNMT3A 
               
               
                 Standard 
                 −13.81 
                 1137663 
                 247362 
                 214909_s_at 
                 DDAH2 
               
               
                 Standard 
                 −13.8 
                 1124864 
                 411317 
                 212960_at 
                 KIAA0882 
               
               
                 Standard 
                 −13.62 
                 1140127 
                 125300 
                 221044_s_at 
                 TRIM34 
               
               
                 Standard 
                 −13.62 
                 1119361 
                 391858 
                 201448_at 
                 TIA1 
               
               
                 Standard 
                 −13.37 
                 1127849 
                 76691 
                 218032_at 
                 SNN 
               
               
                 Standard 
                 13.72 
                 1133192 
                 24024 
                 205801_s_at 
                 RASGRP3 
               
               
                 Standard 
                 13.85 
                 1137583 
                 273415 
                 214687_x_at 
                 ALDOA 
               
               
                 Standard 
                 15.02 
                 1123052 
                 180909 
                 208680_at 
                 PRDX1 
               
               
                 Standard 
                 16.21 
                 1097611 
                 438993 
                 225285_at 
                 BCAT1 
               
               
                 Lymph Node 
                 −19.18 
                 1529456 
                 371468 
                 Lymph_Dx_113_at 
                 CCND1 
               
               
                 Lymph Node 
                 −10.71 
                 1098978 
                 124863 
                 226869_at 
               
               
                 Lymph Node 
                 −9.17 
                 1097448 
                 250607 
                 225093_at 
                 UTRN 
               
               
                 Lymph Node 
                 8.84 
                 1135240 
                 436852 
                 209955_s_at 
                 FAP 
               
               
                 Lymph Node 
                 9.11 
                 1119475 
                 296323 
                 201739_at 
                 SGK 
               
               
                 Lymph Node 
                 9.22 
                 1119237 
                 389964 
                 201141_at 
                 GPNMB 
               
               
                 Lymph Node 
                 9.46 
                 1130629 
                 135226 
                 200839_s_at 
                 CTSB 
               
               
                 Lymph Node 
                 10.1 
                 1130054 
                 82547 
                 221872_at 
                 RARRES1 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                   
                   
                 Standard 
                 Lymph Node 
               
               
                   
                   
               
               
                   
                 Mean MCL 
                 −1417.55 
                 −25.58 
                 Cut 1 
                 0.50 
               
               
                   
                 Mean DLBCL-BL 
                 −756.07 
                 202.29 
                 Cut 2 
                 0.88 
               
               
                   
                 Covariance MCL 
                 15347.98 
                 3525.48 
               
               
                   
                   
                 3525.48 
                 5420.31 
               
               
                   
                 Covariance DLBCL-BL 
                 5132.06 
                 1007.64 
               
               
                   
                   
                 1007.64 
                 991.38 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2413 
               
               
                   
               
               
                 MCL vs. SLL 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Signature 
                 Scale 
                 UNIQID 
                 Unigene ID Build 167 
                 Probe set 
                 Gene Symbol 
               
               
                   
               
               
                 Standard 
                 −20.18 
                 1132834 
                 432638 
                 204914_s_at 
                 SOX11 
               
               
                 Standard 
                 −15.17 
                 1130926 
                 508741 
                 201310_s_at 
                 C5orf13 
               
               
                 Standard 
                 13.44 
                 1116150 
                 16229 
                 227606_s_at 
                 AMSH-LP 
               
               
                 Standard 
                 14.44 
                 1120134 
                 75545 
                 203233_at 
                 IL4R 
               
               
                 Standard 
                 15.18 
                 1529437 
                 445162 
                 Lymph_Dx_175_at 
                 BTLA 
               
               
                 Standard 
                 15.19 
                 1529317 
                 −98 
                 Lymph_Dx_037_at 
               
               
                 Standard 
                 16.2 
                 1135042 
                 79015 
                 209582_s_at 
                 MOX2 
               
               
                   
               
            
           
           
               
               
               
               
               
            
               
                   
                   
                 Standard 
               
               
                   
                   
               
               
                   
                 Mean MCL 
                 181.38 
                 Cut 1 
                 0.20 
               
               
                   
                 Mean SLL 
                 564.92 
                 Cut 2 
                 0.80 
               
               
                   
                 Covariance MCL 
                 1734.42 
               
               
                   
                 Covariance SLL 
                 910.75 
               
               
                   
                   
               
            
           
         
       
     
     
       
         
           
               
             
               
                 TABLE 2414 
               
               
                   
               
               
                 SLL vs. DLBCL-BL 
               
               
                   
               
             
            
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                 Signature 
                 Scale 
                 UNIQID 
                 Unigene ID Build 167 
                 Probe set 
                 Gene Symbol 
               
               
                   
               
               
                 Standard 
                 −16.014498 
                 1123622 
                 8578 
                 210051_at 
                 EPAC 
               
               
                 Standard 
                 −15.26356533 
                 1102081 
                 506977 
                 230551_at 
               
               
                 Standard 
                 −14.82150028 
                 1107044 
                 163426 
                 236458_at 
               
               
                 Standard 
                 −14.17813266 
                 1098865 
                 250905 
                 226741_at 
                 LOC51234 
               
               
                 Standard 
                 −12.92844719 
                 1110740 
                 416810 
                 240538_at 
               
               
                 Standard 
                 −12.86520757 
                 1129026 
                 135146 
                 220007_at 
                 FLJ13984 
               
               
                 Standard 
                 −12.2702748 
                 1135592 
                 758 
                 210621_s_at 
                 RASA1 
               
               
                 Standard 
                 −11.87309449 
                 1117343 
                 306812 
                 234643_x_at 
                 BUCS1 
               
               
                 Standard 
                 −11.81789137 
                 1136987 
                 21695 
                 213370_s_at 
                 SFMBT1 
               
               
                 Standard 
                 −11.78631706 
                 1124830 
                 9059 
                 212911_at 
                 KIAA0962 
               
               
                 Standard 
                 −11.39454435 
                 1133538 
                 1416 
                 206760_s_at 
                 FCER2 
               
               
                 Standard 
                 −11.39050362 
                 1135802 
                 439343 
                 210944_s_at 
                 CAPN3 
               
               
                 Standard 
                 11.72928644 
                 1120770 
                 300825 
                 204493_at 
                 BID 
               
               
                 Lymph Node 
                 −12.21593247 
                 1119880 
                 442844 
                 202709_at 
                 FMOD 
               
               
                 Lymph Node 
                 9.514704847 
                 1135240 
                 436852 
                 209955_s_at 
                 FAP 
               
               
                 Lymph Node 
                 9.739298877 
                 1096429 
                 64896 
                 223405_at 
                 NPL 
               
               
                 Lymph Node 
                 10.05087645 
                 1119475 
                 296323 
                 201739_at 
                 SGK 
               
               
                 Lymph Node 
                 13.11985922 
                 1119237 
                 389964 
                 201141_at 
                 GPNMB 
               
               
                 Proliferation 
                 10.47525875 
                 1128106 
                 14559 
                 218542_at 
                 C10orf3 
               
               
                 Proliferation 
                 10.53295782 
                 1132825 
                 512813 
                 204900_x_at 
                 SAP30 
               
               
                 Proliferation 
                 11.93918891 
                 1130501 
                 2795 
                 200650_s_at 
                 LDHA 
               
               
                 Proliferation 
                 11.98738778 
                 1123439 
                 287472 
                 209642_at 
                 BUB1 
               
               
                 Proliferation 
                 11.99741644 
                 1115607 
                 435733 
                 224428_s_at 
                 CDCA7 
               
               
                   
               
            
           
           
               
               
               
               
               
               
            
               
                   
                 Standard 
                 Lymph Node 
                 Proliferation 
               
               
                   
               
               
                 Mean SLL 
                 −1383.640809 
                 177.4452398 
                 467.2463569 
                 Cut 1 
                 0.201266305 
               
               
                 Mean DLBCL-BL 
                 −926.7275468 
                 329.6795845 
                 582.9070266 
                 Cut 2 
                 0.799816116 
               
               
                 Covariance SLL 
                 3591.384775 
                 1789.7516 
                 856.0703202 
               
               
                   
                 1789.7516 
                 1421.869535 
                 663.4782048 
               
               
                   
                 856.0703202 
                 663.4782048 
                 965.6470151 
               
               
                 Covariance DLBCL-BL 
                 2922.643347 
                 473.543487 
                 634.3258773 
               
               
                   
                 473.543487 
                 931.9845277 
                 −53.85584619 
               
               
                   
                 634.3258773 
                 −53.85584619 
                 767.3545404 
               
               
                   
               
            
           
         
       
     
     The following List of Materials submitted by Compact Disc is provided in accordance with 37 C.F.R. § 1.52(e)(5). Any reference to a table or file in the foregoing specification should be considered an incorporation by reference of the contents of the table and/or file at that particular place in the specification. 
     List of Materials Submitted by Compact Disc 
     
       
         
           
               
               
               
               
             
               
                   
               
             
            
               
                 Table No. 
                 File Name 
                 File size (bytes) 
                 Date Created 
               
               
                   
               
            
           
           
               
            
               
                 Disc 1 of 22 
               
            
           
           
               
               
               
               
            
               
                 2 
                 Table_0002_LymphDx_Probe_List.txt 
                 91,364 
                 Aug. 31, 2004 
               
               
                 3 
                 Table_0003_ABC_304_A.txt 
                 12,168,568 
                 Aug. 10, 2004 
               
               
                 4 
                 Table_0004_ABC_304_B.txt 
                 11,943,114 
                 Aug. 10, 2004 
               
               
                 5 
                 Table_0005_ABC_305_A.txt 
                 12,213,467 
                 Aug. 10, 2004 
               
               
                 6 
                 Table_0006_ABC_305_B.txt 
                 12,154,905 
                 Aug. 10, 2004 
               
               
                 7 
                 Table_0007_ABC_309_A.txt 
                 12,141,759 
                 Aug. 10, 2004 
               
               
                 8 
                 Table_0008_ABC_309_B.txt 
                 11,973,212 
                 Aug. 10, 2004 
               
               
                 9 
                 Table_0009_ABC_413_A.txt 
                 12,301,325 
                 Aug. 10, 2004 
               
               
                 10 
                 Table_0010_ABC_413_B.txt 
                 12,109,937 
                 Aug. 10, 2004 
               
               
                 11 
                 Table_0011_ABC_428_A.txt 
                 12,329,882 
                 Aug. 10, 2004 
               
               
                 12 
                 Table_0012_ABC_428_B.txt 
                 12,126,615 
                 Aug. 10, 2004 
               
               
                 13 
                 Table_0013_ABC_432_A.txt 
                 12,316,197 
                 Aug. 10, 2004 
               
               
                 14 
                 Table_0014_ABC_432_B.txt 
                 12,017,441 
                 Aug. 10, 2004 
               
               
                 15 
                 Table_0015_ABC_446_A.txt 
                 12,285,490 
                 Aug. 10, 2004 
               
               
                 16 
                 Table_0016_ABC_446_B.txt 
                 12,041,763 
                 Aug. 10, 2004 
               
               
                 17 
                 Table_0017_ABC_462_A.txt 
                 12,274,795 
                 Aug. 10, 2004 
               
               
                 18 
                 Table_0018_ABC_452_B.txt 
                 12,056,215 
                 Aug. 10, 2004 
               
               
                 19 
                 Table_0019_ABC_477_A.txt 
                 12,182,261 
                 Aug. 10, 2004 
               
               
                 20 
                 Table_0020_ABC_477_B.txt 
                 12,091,353 
                 Aug. 10, 2004 
               
               
                 21 
                 Table_0021_ABC_481_A.txt 
                 12,311,932 
                 Aug. 10, 2004 
               
               
                 22 
                 Table_0022_ABC_481_B.txt 
                 12,143,332 
                 Aug. 10, 2004 
               
               
                 23 
                 Table_0023_ABC_482_A.txt 
                 12,259,053 
                 Aug. 10, 2004 
               
               
                 24 
                 Table_0024_ABC_482_B.txt 
                 12,126,711 
                 Aug. 10, 2004 
               
               
                 25 
                 Table_0025_ABC_538_A.txt 
                 12,269,821 
                 Aug. 10, 2004 
               
               
                 26 
                 Table_0026_ABC_538_B.txt 
                 12,135,241 
                 Aug. 10, 2004 
               
               
                 27 
                 Table_0027_ABC_541_A.txt 
                 12,159,265 
                 Aug. 11, 2004 
               
               
                 28 
                 Table_0028_ABC_541_B.txt 
                 11,960,425 
                 Aug. 11, 2004 
               
               
                 29 
                 Table_0029_ABC_544_A.txt 
                 12,199,335 
                 Aug. 11, 2004 
               
               
                 30 
                 Table_0030_ABC_544_B.txt 
                 11,995,098 
                 Aug. 11, 2004 
               
               
                 31 
                 Table_0031_ABC_547_A.txt 
                 12,174,490 
                 Aug. 11, 2004 
               
               
                 32 
                 Table_0032_ABC_547_B.txt 
                 11,948,698 
                 Aug. 11, 2004 
               
               
                 33 
                 Table_0033_ABC_577_A.txt 
                 12,015,593 
                 Aug. 11, 2004 
               
               
                 34 
                 Table_0034_ABC_577_B.txt 
                 11,850,326 
                 Aug. 11, 2004 
               
               
                 35 
                 Table_0035_ABC_616_A.txt 
                 12,151,453 
                 Aug. 11, 2904 
               
               
                 36 
                 Table_0036_ABC_616_B.txt 
                 11,877,346 
                 Aug. 11, 2004 
               
               
                 37 
                 Table_0037_ABC_626_A.txt 
                 12,319,773 
                 Aug. 11, 2004 
               
               
                 38 
                 Table_0038_ABC_626_B.txt 
                 12,099,972 
                 Aug. 11, 2004 
               
               
                 39 
                 Table_0039_ABC_633_A.txt 
                 12,144,330 
                 Aug. 11, 2004 
               
               
                 40 
                 Table_0040_ABC_633_B.txt 
                 12,051,373 
                 Aug. 11, 2004 
               
               
                 41 
                 Table_0041_ABC_642_A.txt 
                 12,062,720 
                 Aug. 11, 2004 
               
               
                 42 
                 Table_0042_ABC_642_B.txt 
                 11,924,314 
                 Aug. 11, 2004 
               
               
                 43 
                 Table_0043_ABC_644_A.txt 
                 12,095,292 
                 Aug. 11, 2004 
               
               
                 44 
                 Table_0044_ABC_644_B.txt 
                 12,026,946 
                 Aug. 11, 2004 
               
               
                 45 
                 Table_0045_ABC_645_A.txt 
                 12,142,419 
                 Aug. 11, 2004 
               
               
                 46 
                 Table_0046_ABC_645_B.txt 
                 11,922,646 
                 Aug. 11, 2004 
               
               
                 47 
                 Table_0047_ABC_646_A.txt 
                 12,170,447 
                 Aug. 11, 2004 
               
               
                 48 
                 Table_0048_ABC_646_B.txt 
                 12,005,366 
                 Aug. 11, 2004 
               
               
                 49 
                 Table_0049_ABC_651_A.txt 
                 12,045,047 
                 Aug. 11, 2004 
               
               
                 50 
                 Table_0050_ABC_651_B.txt 
                 11,922,418 
                 Aug. 11, 2004 
               
               
                 51 
                 Table_0051_ABC_652_A.txt 
                 12,103,596 
                 Aug. 11, 2004 
               
               
                 52 
                 Table_0052_ABC_652_B.txt 
                 11,970,072 
                 Aug. 11, 2004 
               
               
                 53 
                 Table_0053_ABC_660_A.txt 
                 12,149,615 
                 Aug. 11, 2004 
               
               
                 54 
                 Table_0054_ABC_660_B.txt 
                 12,035,417 
                 Aug. 11, 2004 
               
               
                 55 
                 Table_0055_ABC_663_A.txt 
                 12,295,719 
                 Aug. 11, 2004 
               
               
                 56 
                 Table_0056_ABC_663_B.txt 
                 12,153,562 
                 Aug. 11, 2004 
               
            
           
           
               
            
               
                 Disc 2 of 22 
               
            
           
           
               
               
               
               
            
               
                 57 
                 Table_0057_ABC_668_A.txt 
                 12,254,586 
                 Aug. 11, 2004 
               
               
                 58 
                 Table_0058_ABC_668_B.txt 
                 12,077,180 
                 Aug. 11, 2004 
               
               
                 59 
                 Table_0059_ABC_676_A.txt 
                 12,042,636 
                 Aug. 11, 2004 
               
               
                 60 
                 Table_0060_ABC_676_B.txt 
                 11,923,373 
                 Aug. 11, 2004 
               
               
                 61 
                 Table_0061_ABC_678_A.txt 
                 12,051,214 
                 Aug. 11, 2004 
               
               
                 62 
                 Table_0002_ABC_678_B.txt 
                 11,885,465 
                 Aug. 11, 2004 
               
               
                 63 
                 Table_0063_ABC_687_A.txt 
                 12,288,163 
                 Aug. 11, 2004 
               
               
                 64 
                 Table_0064_ABC_687_B.txt 
                 12,114,176 
                 Aug. 11, 2004 
               
               
                 65 
                 Table_0065_ABC_689_A.txt 
                 12,239,706 
                 Aug. 11, 2004 
               
               
                 66 
                 Table_0066_ABC_689_B.txt 
                 11,999,699 
                 Aug. 11, 2004 
               
               
                 67 
                 Table_0067_ABC_692_A.txt 
                 12,193,147 
                 Aug. 11, 2004 
               
               
                 68 
                 Table_0068_ABC_692_B.txt 
                 11,876,485 
                 Aug. 11, 2004 
               
               
                 69 
                 Table_0069_ABC_694_A.txt 
                 12,256,974 
                 Aug. 11, 2004 
               
               
                 70 
                 Table_0070_ABC_694_B.txt 
                 12,011,057 
                 Aug. 11, 2004 
               
               
                 71 
                 Table_0071_ABC_700_A.txt 
                 12,085,982 
                 Aug. 11, 2004 
               
               
                 72 
                 Table_0072_ABC_700_B.txt 
                 11,917,957 
                 Aug. 11, 2004 
               
               
                 73 
                 Table_0073_ABC_702_A.txt 
                 12,121,512 
                 Aug. 11, 2004 
               
               
                 74 
                 Table_0074_ABC_702_B.txt 
                 11,939,438 
                 Aug. 11, 2004 
               
               
                 75 
                 Table_0075_ABC_704_A.txt 
                 12,287,602 
                 Aug. 11, 2004 
               
               
                 76 
                 Table_0076_ABC_704_B.txt 
                 12,103,199 
                 Aug. 11, 2004 
               
               
                 77 
                 Table_0077_ABC_709_A.txt 
                 12,212,735 
                 Aug. 11, 2004 
               
               
                 78 
                 Table_0078_ABC_709_B.txt 
                 11,967,460 
                 Aug. 11, 2004 
               
               
                 79 
                 Table_0079_ABC_712_A.txt 
                 12,253,447 
                 Aug. 11, 2004 
               
               
                 80 
                 Table_0080_ABC_712_B.txt 
                 12,070,582 
                 Aug. 11, 2004 
               
               
                 81 
                 Table_0081_ABC_714_A.txt 
                 12,144,498 
                 Aug. 11, 2004 
               
               
                 82 
                 Table_0082_ABC_714_B.txt 
                 11,920,284 
                 Aug. 11, 2004 
               
               
                 83 
                 Table_0083_ABC_717_A.txt 
                 12,142,496 
                 Aug. 11, 2004 
               
               
                 84 
                 Table_0084_ABC_717_B.txt 
                 11,954,244 
                 Aug. 11, 2004 
               
               
                 85 
                 Table_0085_ABC_725_A.txt 
                 12,080,186 
                 Aug. 11, 2004 
               
               
                 86 
                 Table_0086_ABC_725_B.txt 
                 11,751,528 
                 Aug. 11, 2004 
               
               
                 87 
                 Table_0087_ABC_726_A.txt 
                 11,989,772 
                 Aug. 11, 2004 
               
               
                 88 
                 Table_0088_ABC_726_B.txt 
                 11,763,881 
                 Aug. 11, 2004 
               
               
                 89 
                 Table_0089_ABC_730_A.txt 
                 12,080,456 
                 Aug. 11, 2004 
               
               
                 90 
                 Table_0090_ABC_730_B.txt 
                 11,902,874 
                 Aug. 11, 2004 
               
               
                 91 
                 Table_0091_ABC_753_A.txt 
                 12,200,060 
                 Aug. 11, 2004 
               
               
                 92 
                 Table_0092_ABC_753_B.txt 
                 11,936,481 
                 Aug. 11, 2004 
               
               
                 93 
                 Table_0093_ABC_756_A.txt 
                 12,280,005 
                 Aug. 11, 2004 
               
               
                 94 
                 Table_0094_ABC_756_B.txt 
                 11,983,560 
                 Aug. 11, 2004 
               
               
                 95 
                 Table_0095_ABC_771_A.txt 
                 12,137,758 
                 Aug. 11, 2004 
               
               
                 96 
                 Table_0096_ABC_771_B.txt 
                 11,975,832 
                 Aug. 11, 2004 
               
               
                 97 
                 Table_0097_ABC_779_A.txt 
                 12,297,481 
                 Aug. 11, 2004 
               
               
                 98 
                 Table_0098_ABC_779_B.txt 
                 12,002,334 
                 Aug. 11, 2004 
               
               
                 99 
                 Table_0099_ABC_789_A.txt 
                 12,206,349 
                 Aug. 11, 2004 
               
               
                 100 
                 Table_0100_ABC_789_B.txt 
                 12,016,648 
                 Aug. 11, 2004 
               
               
                 101 
                 Table_0101_ABC_800_A.txt 
                 12,003,215 
                 Aug. 11, 2004 
               
               
                 102 
                 Table_0102_ABC_800_B.txt 
                 11,934,562 
                 Aug. 11, 2004 
               
               
                 103 
                 Table_0103_ABC_807_A.txt 
                 12,103,858 
                 Aug. 11, 2004 
               
               
                 104 
                 Table_0104_ABC_807_B.txt 
                 11,887,326 
                 Aug. 11, 2004 
               
               
                 105 
                 Table_0105_ABC_809_A.txt 
                 12,058,952 
                 Aug. 11, 2004 
               
               
                 106 
                 Table_0106_ABC_809_B.txt 
                 11,797,773 
                 Aug. 11, 2004 
               
               
                 107 
                 Table_0107_ABC_816_A.txt 
                 11,979,780 
                 Aug. 11, 2004 
               
               
                 108 
                 Table_0108_ABC_816_B.txt 
                 11,874,102 
                 Aug. 11, 2004 
               
               
                 109 
                 Table_0109_ABC_820_A.txt 
                 12,073,993 
                 Aug. 11, 2004 
               
               
                 110 
                 Table_0110_ABC_820_B.txt 
                 11,837,974 
                 Aug. 11, 2004 
               
            
           
           
               
            
               
                 Disc 3 of 22 
               
            
           
           
               
               
               
               
            
               
                 111 
                 Table_0111_ABC_823_A.txt 
                 12,082,433 
                 Aug. 11, 2004 
               
               
                 112 
                 Table_0112_ABC_823_B.txt 
                 11,864,483 
                 Aug. 11, 2004 
               
               
                 113 
                 Table_0113_ABC_835_A.txt 
                 12,235,272 
                 Aug. 11, 2004 
               
               
                 114 
                 Table_0114_ABC_835_B.txt 
                 12,002,461 
                 Aug. 11, 2004 
               
               
                 115 
                 Table_0115_ABC_839_A.txt 
                 12,203,437 
                 Aug. 11, 2004 
               
               
                 116 
                 Table_0116_ABC_839_B.txt 
                 11,920,023 
                 Aug. 11, 2004 
               
               
                 117 
                 Table_0117_ABC_841_A.txt 
                 12,331,151 
                 Aug. 11, 2004 
               
               
                 118 
                 Table_0118_ABC_841_B.txt 
                 12,078,461 
                 Aug. 11; 2004 
               
               
                 119 
                 Table_0119_ABC_858_A.txt 
                 12,207,153 
                 Aug. 11, 2004 
               
               
                 120 
                 Table_0120_ABC_858_B.txt 
                 12,040,055 
                 Aug. 11, 2004 
               
               
                 121 
                 Table_0121_ABC_872_A.txt 
                 12,160,913 
                 Aug. 11, 2004 
               
               
                 122 
                 Table_0122_ABC_872_B.txt 
                 11,972,706 
                 Aug. 11, 2004 
               
               
                 123 
                 Table_0123_ABC_875_A.txt 
                 12,062,435 
                 Aug. 11, 2Q04 
               
               
                 124 
                 Table_0124_ABC_875_B.txt 
                 11,868,039 
                 Aug. 11, 2004 
               
               
                 125 
                 Table_0125_ABC_912_A.txt 
                 12,203,349 
                 Aug. 11, 2004 
               
               
                 126 
                 Table_0126_ABC_912_B.txt 
                 12,056,482 
                 Aug. 11, 2004 
               
               
                 127 
                 Table_0127_ABC_996_A.txt 
                 12,145,520 
                 Aug. 11, 2004 
               
               
                 128 
                 Table_0128_ABC_996_B.txt 
                 11,926,049 
                 Aug. 11, 2004 
               
               
                 129 
                 Table_0129_ABC_1000_A.txt 
                 12,172,512 
                 Aug. 10, 2004 
               
               
                 130 
                 Table_0130_ABC_1000_B.txt 
                 11,960,378 
                 Aug. 10, 2004 
               
               
                 131 
                 Table_0131_ABC_1002_A.txt 
                 12,136,443 
                 Aug. 10, 2004 
               
               
                 132 
                 Table_0132_ABC_1002_B.txt 
                 11,912,994 
                 Aug. 10, 2004 
               
               
                 133 
                 Table_0133_ABC_1023_A.txt 
                 12,043,351 
                 Aug. 10, 2004 
               
               
                 134 
                 Table_0134_ABC_1023_B.txt 
                 12,005,776 
                 Aug. 10, 2004 
               
               
                 135 
                 Table_0135_ABC_1027_A.txt 
                 12,225,822 
                 Aug. 10, 2004 
               
               
                 136 
                 Table_0136_ABC_1027_B.txt 
                 12,090,475 
                 Aug. 10, 2004 
               
               
                 137 
                 Table_0137_ABC_1031_A.txt 
                 12,144,420 
                 Aug. 10, 2004 
               
               
                 138 
                 Table_0138_ABC_1031_B.txt 
                 12,031,947 
                 Aug. 10, 2004 
               
               
                 139 
                 Table_0139_ABC_1034_A.txt 
                 12,086,509 
                 Aug. 10, 2004 
               
               
                 140 
                 Table_0140_ABC_1034_B.txt 
                 12,009,740 
                 Aug. 10, 2004 
               
               
                 141 
                 Table_0141_ABC_1038_A.txt 
                 12,141,976 
                 Aug. 10, 2004 
               
               
                 142 
                 Table_0142_ABC_1038_B.txt 
                 12,000,420 
                 Aug. 10, 2004 
               
               
                 143 
                 Table_0143_ABC_1043_A.txt 
                 12,139,378 
                 Aug. 10, 2004 
               
               
                 144 
                 Table_0144_ABC_1043_B.txt 
                 11,983,541 
                 Aug. 10, 2004 
               
               
                 145 
                 Table_0145_ABC_1045_A.txt 
                 11,979,407 
                 Aug. 10, 2004 
               
               
                 144 
                 Table_0146_ABC_1045_B.txt 
                 11,901,031 
                 Aug. 10, 2004 
               
               
                 147 
                 Table_0147_ABC_1055_A.txt 
                 12,018,874 
                 Aug. 10, 2004 
               
               
                 148 
                 Table_0148_ABC_1055_B.txt 
                 11,954,387 
                 Aug. 10, 2004 
               
               
                 149 
                 Table_0149_ABC_1057_A.txt 
                 12,062,420 
                 Aug. 10, 2004 
               
               
                 150 
                 Table_0150_ABC_1057_B.txt 
                 11,923,795 
                 Aug. 10, 2004 
               
               
                 151 
                 Table_0151_ABC_1059_A.txt 
                 12,037,304 
                 Aug. 10, 2004 
               
               
                 152 
                 Table_0152_ABC_1059_B.txt 
                 11,846,923 
                 Aug. 10, 2004 
               
               
                 153 
                 Table_0153_ABC_1061_A.txt 
                 12,162,153 
                 Aug. 10, 2004 
               
               
                 154 
                 Table_0154_ABC_1061_B.txt 
                 11,957,326 
                 Aug. 10, 2004 
               
               
                 155 
                 Table_0155_ABC_1994_A.txt 
                 12,063,327 
                 Aug. 10, 2004 
               
               
                 156 
                 Table_0156_ABC_1994_B.txt 
                 11,792,424 
                 Aug. 10, 2004 
               
               
                 157 
                 Table_0157_ABC_2001_A.txt 
                 12,144,366 
                 Aug. 10, 2004 
               
               
                 158 
                 Table_0158_ABC_2001_B.txt 
                 11,966,468 
                 Aug. 10, 2004 
               
               
                 159 
                 Table_0159_BL_2032_A.txt 
                 12,259,980 
                 Aug. 12, 2004 
               
               
                 160 
                 Table_0160_BL_2032_B.txt 
                 11,940,823 
                 Aug. 12, 2004 
               
               
                 161 
                 Table_0161_BL_2033_A.txt 
                 12,118,946 
                 Aug. 13, 2004 
               
               
                 162 
                 Table_0462_BL_2033_B.txt 
                 11,844,470 
                 Aug. 13, 2004 
               
               
                 163 
                 Table_0163_BL_2035_A.txt 
                 12,122,606 
                 Aug. 13, 2004 
               
               
                 164 
                 Table_0164_BL_2035_B.txt 
                 11,910,764 
                 Aug. 13, 2004 
               
            
           
           
               
            
               
                 Disc 4 of 22 
               
            
           
           
               
               
               
               
            
               
                 165 
                 Table_0165_BL_2036_A.txt 
                 12,079,985 
                 Aug. 13,2004 
               
               
                 166 
                 Table_0166_BL_2036_B.txt 
                 11,804,136 
                 Aug. 13,2004 
               
               
                 167 
                 Table_0167_BL_2037_A.txt 
                 12,236,363 
                 Aug. 13,2004 
               
               
                 168 
                 Table_0168_BL_2037_B.txt 
                 12,114,941 
                 Aug. 13,2004 
               
               
                 169 
                 Table_0169_BL_2038_A.txt 
                 12,044,025 
                 Aug. 13,2004 
               
               
                 170 
                 Table_0170_BL_2038_B.txt 
                 11,887,911 
                 Aug. 13,2004 
               
               
                 171 
                 Table_0171_BL_2082_A.txt 
                 11,857,967 
                 Aug. 13,2004 
               
               
                 172 
                 Table_0172_BL_2082_B.txt 
                 11,730,035 
                 Aug. 13,2004 
               
               
                 173 
                 Table_0173_BL_2083_A.txt 
                 11,963,716 
                 Aug. 13,2004 
               
               
                 174 
                 Table_0174_BL_2083_B.txt 
                 11,796,670 
                 Aug. 13 2004 
               
               
                 175 
                 Table_0175_BL_2086_A.txt 
                 12,104,019 
                 Aug. 13,2004 
               
               
                 176 
                 Table_0176_BL_2086_B.txt 
                 11,965,947 
                 Aug. 13,2004 
               
               
                 177 
                 Table_0177_BL_2088_A.txt 
                 11,933,503 
                 Aug. 13,2004 
               
               
                 178 
                 Table_0178_BL_2088_B.txt 
                 11,706,861 
                 Aug. 13,2004 
               
               
                 179 
                 Table_0179_BL_2090_A.txt 
                 12,174,470 
                 Aug. 13,2004 
               
               
                 180 
                 Table_0180_BL_2090_B.txt 
                 12,102,048 
                 Aug. 13,2004 
               
               
                 181 
                 Table_0181_BL_2091_A.txt 
                 12,053,564 
                 Aug. 13,2004 
               
               
                 182 
                 Table_0182_BL_2091_B.txt 
                 12,003,445 
                 Aug. 13,2004 
               
               
                 183 
                 Table_0183_BL_2097_A.txt 
                 12,060,060 
                 Aug. 13,2004 
               
               
                 184 
                 Table_0184_BL_2097_B.txt 
                 11,779,676 
                 Aug. 13,2004 
               
               
                 185 
                 Table_0185_BL_2099_A.txt 
                 12,082,566 
                 Aug. 13,2004 
               
               
                 186 
                 Table_0186_BL_2099_B.txt 
                 11,894,123 
                 Aug. 13,2004 
               
               
                 187 
                 Table_0187_BL_2100_A.txt 
                 12,090,939 
                 Aug. 13,2004 
               
               
                 188 
                 Table_0188_BL_2100_B.txt 
                 11,854,774 
                 Aug. 13,2004 
               
               
                 189 
                 Table_0189_BL_2101_A.txt 
                 12,077,697 
                 Aug. 13, 2004 
               
               
                 190 
                 Table_0190_BL_2101_B.txt 
                 11,863,914 
                 Aug. 13, 2004 
               
               
                 191 
                 Table_0191_BL_2103_A.txt 
                 12,181,215 
                 Aug. 13, 2004 
               
               
                 192 
                 Table_0192_BL_2103_B.txt 
                 11,983,322 
                 Aug. 13, 2004 
               
               
                 193 
                 Table_0193_BL_2125_A.txt 
                 12,171,375 
                 Aug. 13, 2004 
               
               
                 194 
                 Table_0194_BL_2125_B.txt 
                 12,007,032 
                 Aug. 13, 2004 
               
               
                 195 
                 Table_0195_BL_2126_A.txt 
                 12,175,436 
                 Aug. 13, 2004 
               
               
                 196 
                 Table_0196_BL_2126_B.txt 
                 12,022,582 
                 Aug. 13, 2004 
               
               
                 197 
                 Table_0197_BL_2127_A.txt 
                 12,154,107 
                 Aug. 13, 2004 
               
               
                 198 
                 Table_0198_BL_2127_B.txt 
                 12,008,547 
                 Aug. 13, 2004 
               
               
                 199 
                 Table_0199_BL_2128_A.txt 
                 12,052,741 
                 Aug. 13, 2004 
               
               
                 200 
                 Table_0200_BL_2128_B.txt 
                 11,936,004 
                 Aug. 13, 2004 
               
               
                 201 
                 Table_0201_BL_2129_A.txt 
                 12,103,006 
                 Aug. 13, 2004 
               
               
                 202 
                 Table_0202_BL_2129_B.txt 
                 12,004,781 
                 Aug. 13, 2004 
               
               
                 203 
                 Table_0203_BL_2267_A.txt 
                 12,233,969 
                 Aug. 13, 2004 
               
               
                 204 
                 Table_0204_BL_2267_B.txt 
                 12,000,442 
                 Aug. 13, 2004 
               
               
                 205 
                 Table_0205_BL_2268_A.txt 
                 12,235,002 
                 Aug. 13, 2004 
               
               
                 206 
                 Table_0206_BL_2268_B.txt 
                 12,040,217 
                 Aug. 13, 2004 
               
               
                 207 
                 Table_0207_BL_2269_A.txt 
                 12,293,134 
                 Aug. 13, 2004 
               
               
                 208 
                 Table_0208_BL_2269_B.txt 
                 12,083,796 
                 Aug. 13, 2004 
               
               
                 209 
                 Table_0209_BL_2271_A.txt 
                 12,251,188 
                 Aug. 13, 2004 
               
               
                 210 
                 Table_0210_BL_2271_B.txt 
                 12,033,626 
                 Aug. 13, 2004 
               
               
                 211 
                 Table_0211_CD1negMCL_1013_A.txt 
                 12,069,354 
                 Aug. 12, 2004 
               
               
                 212 
                 Table_0212_CD1negMCL_1013_B.txt 
                 11,916,758 
                 Aug. 12, 2004 
               
               
                 213 
                 Table_0213_CD1negMCL_1161_A.txt 
                 12,063,571 
                 Aug. 12, 2004 
               
               
                 214 
                 Table_0214_CD1negMCL_1116_B.txt 
                 11,602,903 
                 Aug. 12, 2004 
               
               
                 215 
                 Table_0215_CD1negMCL_1125_A.txt 
                 11,980,433 
                 Aug. 12, 2004 
               
               
                 216 
                 Table_0216_CD1negMCL_1125_B.txt 
                 11,802,606 
                 Aug. 12, 2004 
               
               
                 217 
                 Table_0217_CD1negMCL_1265_A.txt 
                 12,073,913 
                 Aug. 12, 2004 
               
               
                 218 
                 Table_0218_CD1negMCL_1265_B.txt 
                 11,806,792 
                 Aug. 12, 2004 
               
               
                 219 
                 Table_0219_CD1negMCL_2198_A.txt 
                 12,205,777 
                 Aug. 12, 2004 
               
               
                 220 
                 Table_0220_CD1negMCL_2198_B.txt 
                 11,953,251 
                 Aug. 12, 2004 
               
            
           
           
               
            
               
                 Disc 5 of 22 
               
            
           
           
               
               
               
               
            
               
                 221 
                 Table_0221_CD1negMCL_2272_A.txt 
                 12,140,519 
                 Aug. 12, 2004 
               
               
                 222 
                 Table_0222_CD1negMCL_2272_B.txt 
                 11,903,198 
                 Aug. 12, 2004 
               
               
                 223 
                 Table_0223_CD1hegMCL_930_A.txt 
                 12,085,551 
                 Aug. 12, 2004 
               
               
                 224 
                 Table_0224_CD1negMCL_930_B.txt 
                 12,029,054 
                 Aug. 12, 2004 
               
               
                 225 
                 Table_0225_CD1negMCL_950_A.txt 
                 12,048,303 
                 Aug. 12, 2004 
               
               
                 226 
                 Table_0226_CD1negMCL_950_B.txt 
                 11,966,572 
                 Aug. 12, 2004 
               
               
                 227 
                 Table_0227_CD1negMCL_985_A.txt 
                 12,152,037 
                 Aug. 12, 2004 
               
               
                 228 
                 Table_0228_CD1negMCL_985_B.txt 
                 11,987,764 
                 Aug. 12, 2004 
               
               
                 229 
                 Table_0229_CD1negMCL_991_A.txt 
                 11,970,755 
                 Aug. 12, 2004 
               
               
                 230 
                 Table_0230_CD1negMCL_991_B.txt 
                 11,906,922 
                 Aug. 12, 2004 
               
               
                 231 
                 Table_0231_FH_2043_A.txt 
                 12,107,383 
                 Aug. 13, 2004 
               
               
                 232 
                 Table_0232_FH_2043_B.txt 
                 11,759,404 
                 Aug. 13, 2004 
               
               
                 233 
                 Table_0233_FH_2045_A.txt 
                 12,018,780 
                 Aug. 13, 2004 
               
               
                 234 
                 Table_0234_FH_2045_B.txt 
                 11,760,937 
                 Aug. 13, 2004 
               
               
                 235 
                 Table_0235_FH_2047_A.txt 
                 12,196,386 
                 Aug. 13, 2004 
               
               
                 236 
                 Table_0236_FH_2047_B.txt 
                 12,038,844 
                 Aug. 13, 2004 
               
               
                 237 
                 Table_0237_FH_2120_A.txt 
                 12,057,634 
                 Aug. 13, 2004 
               
               
                 238 
                 Table_0238_FH_2120_B.txt 
                 11,899,644 
                 Aug. 13, 2004 
               
               
                 239 
                 Table_0239_FH_2123_A.txt 
                 12,102,087 
                 Aug. 13, 2004 
               
               
                 240 
                 Table_0240_FH_2123_B.txt 
                 11,974,939 
                 Aug. 13, 2004 
               
               
                 241 
                 Table_0241_FH_2124_A.txt 
                 11,981,409 
                 Aug. 13, 2004 
               
               
                 242 
                 Table_0242_FH_2124_B.txt 
                 11,728,703 
                 Aug. 13, 2004 
               
               
                 243 
                 Table_0243_FH_2138_A.txt 
                 12,246,913 
                 Aug. 13, 2004 
               
               
                 244 
                 Table_0244_FH_2138_B.txt 
                 12,113,245 
                 Aug. 13, 2004 
               
               
                 245 
                 Table_0245_FH_2139_A.txt 
                 12,131,403 
                 Aug. 13, 2004 
               
               
                 248 
                 Table_0246_FH_2139_B.txt 
                 12,113,768 
                 Aug. 13, 2004 
               
               
                 247 
                 Table_0247_FH_2140_A.txt 
                 12,195,197 
                 Aug. 13, 2004 
               
               
                 248 
                 Table_0248_FH_2140_B.txt 
                 12,119,738 
                 Aug. 13, 2004 
               
               
                 249 
                 Table_0249_FH_2141_A.txt 
                 12,208,402 
                 Aug. 13, 2004 
               
               
                 250 
                 Table_0250_FH_2141_B.txt 
                 12,147,002 
                 Aug. 13, 2004 
               
               
                 251 
                 Table_0251_FH_2142_A.txt 
                 12,219,828 
                 Aug. 12, 2004 
               
               
                 252 
                 Table_0252_FH_2142_B.txt 
                 12,085,775 
                 Aug. 13, 2004 
               
               
                 253 
                 Table_0253_FH_2143_A.txt 
                 12,006,329 
                 Aug. 13, 2004 
               
               
                 254 
                 Table_0254_FH_2143_B.txt 
                 11,935,243 
                 Aug. 13, 2004 
               
               
                 255 
                 Table_0255_FH_2159_A.txt 
                 12,188,960 
                 Aug. 13, 2004 
               
               
                 256 
                 Table_0256_FH_2159_B.txt 
                 11,879,679 
                 Aug. 12, 2004 
               
               
                 257 
                 Table_0257_FH_2160_A.txt 
                 12,192,094 
                 Aug. 13, 2004 
               
               
                 258 
                 Table_0258_FH_2160_B.txt 
                 11,931,687 
                 Aug. 13, 2004 
               
               
                 259 
                 Table_0259_FH_2161_A.txt 
                 12,253,214 
                 Aug. 13, 2004 
               
               
                 260 
                 Table_0260_FH_2161_B.txt 
                 12,051,739 
                 Aug. 16, 2004 
               
               
                 261 
                 Table_0261_FH_2162_A.txt 
                 12,191,210 
                 Aug. 16, 2004 
               
               
                 262 
                 Table_0262_FH_2162_B.txt 
                 11,952,602 
                 Aug. 13, 2004 
               
               
                 263 
                 Table_0263_FH_2164_A.txt 
                 12,272,173 
                 Aug. 13, 2004 
               
               
                 264 
                 Table_0264_FH_2164_B.txt 
                 12,019,060 
                 Aug. 13, 2004 
               
               
                 265 
                 Table_0265_FH_2167_A.txt 
                 12,337,573 
                 Aug. 13, 2004 
               
               
                 266 
                 Table_0266_FH_2167_B.txt 
                 12,107,528 
                 Aug. 16, 2004 
               
               
                 267 
                 Table_0267_FL_1073_A.txt 
                 12,249,411 
                 Aug. 13, 2004 
               
               
                 268 
                 Table_0268_FL_1073_B.txt 
                 12,008,104 
                 Aug. 16, 2004 
               
               
                 269 
                 Table_0269_FL_1074_A.txt 
                 12,197,601 
                 Aug. 13, 2004 
               
               
                 270 
                 Table_0270_FL_1074_B.txt 
                 11,933,006 
                 Aug. 16, 2004 
               
               
                 271 
                 Table_0271_FL_1075_A.txt 
                 12,222,781 
                 Aug. 16, 2004 
               
               
                 272 
                 Table_0272_FL_1075_B.txt 
                 12,070,708 
                 Aug. 13, 2004 
               
               
                 273 
                 Table_0273_FL_1076_A.txt 
                 12,270,162 
                 Aug. 16, 2004 
               
               
                 274 
                 Table_0274_FL_1076_B.txt 
                 12,076,340 
                 Aug. 16, 2004 
               
               
                 275 
                 Table_0275_FL_1077_A.txt 
                 12,180,432 
                 Aug. 16, 2004 
               
               
                 276 
                 Table_0276_FL_1077_B.txt 
                 11,836,673 
                 Aug. 13, 2004 
               
            
           
           
               
            
               
                 Disc 6 of 22 
               
            
           
           
               
               
               
               
            
               
                 277 
                 Table_0277_FL_1078_A.txt 
                 12,240,701 
                 Aug. 13, 2004 
               
               
                 278 
                 Table_0278_FL_1078_B.txt 
                 11,975,063 
                 Aug. 13, 2004 
               
               
                 279 
                 Table_0279_FL_1080_A.txt 
                 12,227,672 
                 Aug. 13, 2004 
               
               
                 280 
                 Table_0280_FL_1080_B.txt 
                 12,004,087 
                 Aug. 16, 2004 
               
               
                 281 
                 Table_0281_FL_1081_A.txt 
                 12,081,406 
                 Aug. 13, 2004 
               
               
                 282 
                 Table_0282_FL_1081_B.txt 
                 11,942,019 
                 Aug. 16, 2004 
               
               
                 283 
                 Table_0283_FL_1083_A.txt 
                 12,197,692 
                 Aug. 13, 2004 
               
               
                 284 
                 Table_0284_FL_1083_B.txt 
                 12,000,356 
                 Aug. 13, 2004 
               
               
                 285 
                 Table_0285_FL_1085_A.txt 
                 12,198,722 
                 Aug. 13, 2004 
               
               
                 286 
                 Table_0286_FL_1085_B.txt 
                 11,966,361 
                 Aug. 16, 2004 
               
               
                 287 
                 Table_0287_FL_1086_A.txt 
                 12,202,810 
                 Aug. 13, 2004 
               
               
                 288 
                 Table_0288_FL_1086_B.txt 
                 12,059,339 
                 Aug. 16, 2004 
               
               
                 289 
                 Table_0289_FL_735_A.txt 
                 12,093,811 
                 Aug. 15, 2004 
               
               
                 290 
                 Table_0290_FL_735_B.txt 
                 11,986,038 
                 Aug. 13, 2004 
               
               
                 291 
                 Table_0291_FL_738_A.txt 
                 12,150,187 
                 Aug. 16, 2004 
               
               
                 292 
                 Table_0292_FL_738_B.txt 
                 11,937,614 
                 Aug. 13, 2004 
               
               
                 293 
                 Table_0293_FL_739_A.txt 
                 12,166,069 
                 Aug. 16, 2004 
               
               
                 294 
                 Table_0294_FL_739_B.txt 
                 11,924,390 
                 Aug. 13, 2004 
               
               
                 295 
                 Table_0295_FL_878_A.txt 
                 12,199,551 
                 Aug. 16, 2004 
               
               
                 296 
                 Table_0296_FL_878_B.txt 
                 11,965,688 
                 Aug. 16, 2004 
               
               
                 297 
                 Table_0297_FL_879_A.txt 
                 12,153,527 
                 Aug. 16, 2004 
               
               
                 298 
                 Table_0298_FL_879_B.txt 
                 11,953,408 
                 Aug. 13, 2004 
               
               
                 299 
                 Table_0299_FL_886_A.txt 
                 12,167,246 
                 Aug. 13, 2004 
               
               
                 300 
                 Table_0300_FL_886_B.txt 
                 11,837,538 
                 Aug. 16, 2004 
               
               
                 301 
                 Table_0301_FL_888_A.txt 
                 12,069,433 
                 Aug. 16, 2004 
               
               
                 302 
                 Table_0302_FL_888_B.txt 
                 1,768,475 
                 Aug. 16, 2004 
               
               
                 303 
                 Table_0303_FL_1087_A.txt 
                 12,234,602 
                 Aug. 16, 2004 
               
               
                 304 
                 Table_0304_FL_1087_B.txt 
                 12,029,081 
                 Aug. 16, 2004 
               
               
                 305 
                 Table_0305_FL_1088_A.txt 
                 12,176,960 
                 Aug. 12, 2004 
               
               
                 306 
                 Table_0306_FL_1088_B.txt 
                 11,929,385 
                 Aug. 13, 2004 
               
               
                 307 
                 Table_0307_FL_1089_A.txt 
                 12,235,001 
                 Aug. 16, 2004 
               
               
                 308 
                 Table_0308_FL_1089_B.txt 
                 12,002,707 
                 Aug. 16, 2004 
               
               
                 309 
                 Table_0309_FL_1090_A.txt 
                 12,187,091 
                 Aug. 13, 2004 
               
               
                 310 
                 Table_0310_FL_1090_B.txt 
                 11,930,228 
                 Aug. 13, 2004 
               
               
                 311 
                 Table_0311_FL_1097_A.txt 
                 12,035,807 
                 Aug. 12, 2004 
               
               
                 312 
                 Table_0312_FL_1097_B.txt 
                 11,998,469 
                 Aug. 12, 2004 
               
               
                 313 
                 Table_0313_FL_1098_A.txt 
                 12,163,535 
                 Aug. 13, 2004 
               
               
                 314 
                 Table_0314_FL_1098_B.txt 
                 11,910,993 
                 Aug. 12, 2004 
               
               
                 315 
                 Table_0315_FL_1099_A.txt 
                 12,140,701 
                 Aug. 16, 2004 
               
               
                 316 
                 Table_0316_FL_1099_B.txt 
                 11,963,778 
                 Aug. 12, 2004 
               
               
                 317 
                 Table_0317_FL_1102_A.txt 
                 12,041,808 
                 Aug. 13, 2004 
               
               
                 318 
                 Table_0318_FL_1102_B.txt 
                 11,873,396 
                 Aug. 13, 2004 
               
               
                 319 
                 Table_0319_FL_1104_A.txt 
                 12,147,511 
                 Aug. 16, 2004 
               
               
                 320 
                 Table_0320_FL_1104_B.txt 
                 11,972,622 
                 Aug. 12, 2004 
               
               
                 321 
                 Table_0321_FL_1106_A.txt 
                 12,074,579 
                 Aug. 13, 2004 
               
               
                 322 
                 Table_0322_FL_1106_B.txt 
                 11,991,893 
                 Aug. 16, 2004 
               
               
                 323 
                 Table_0323_FL_1107_A.txt 
                 12,022,734 
                 Aug. 13, 2004 
               
               
                 324 
                 Table_0324_FL_1107_B.txt 
                 11,887,794 
                 Aug. 16, 2004 
               
               
                 325 
                 Table_0325_FL_1183_A.txt 
                 12,062,144 
                 Aug. 16, 2004 
               
               
                 326 
                 Table_0326_FL_1183_B.txt 
                 11,831,515 
                 Aug. 16, 2004 
               
               
                 327 
                 Table_0327_FL_1184_A.txt 
                 12,095,457 
                 Aug. 13, 2004 
               
               
                 328 
                 Table_0328_FL_1184_B.txt 
                 11,978,023 
                 Aug. 16, 2004 
               
               
                 329 
                 Table_0329_FL_1185_A.txt 
                 11,929,326 
                 Aug. 13, 2004 
               
               
                 330 
                 Table_0330_FL_1185_B.txt 
                 11,784,070 
                 Aug. 12, 2004 
               
               
                 331 
                 Table_0331_FL_1186_A.txt 
                 11,962,956 
                 Aug. 16, 2004 
               
               
                 332 
                 Table_0332_FL_1186_B.txt 
                 11,896,127 
                 Aug. 12, 2004 
               
            
           
           
               
            
               
                 Disc 7 of 22 
               
            
           
           
               
               
               
               
            
               
                 333 
                 Table_0333_FL_1416_A.txt 
                 12,185,087 
                 Aug. 16, 2004 
               
               
                 334 
                 Table_0334_FL_1416_B.txt 
                 12,073,389 
                 Aug. 12, 2004 
               
               
                 335 
                 Table_0335_FL_1417_A.txt 
                 12,131,418 
                 Aug. 13, 2004 
               
               
                 336 
                 Table_0336_FL_1417_B.txt 
                 12,019,667 
                 Aug. 13, 2004 
               
               
                 337 
                 Table_0337_FL_1418_A.txt 
                 12,063,921 
                 Aug. 13, 2004 
               
               
                 338 
                 Table_0338_FL_1418_B.txt 
                 11,790,370 
                 Aug. 16, 2004 
               
               
                 339 
                 Table_0339_FL_1419_A.txt 
                 12,182,797 
                 Aug. 16, 2004 
               
               
                 340 
                 Table_0340_FL_1419_B.txt 
                 12,070,844 
                 Aug. 16, 2004 
               
               
                 341 
                 Table_0341_FL_1422_A.txt 
                 12,008,099 
                 Aug. 13, 2004 
               
               
                 342 
                 Table_0342_FL_1422_B.txt 
                 11,933,820 
                 Aug. 13, 2004 
               
               
                 343 
                 Table_0343_FL_1425_A.txt 
                 12,144,306 
                 Aug. 16, 2004 
               
               
                 344 
                 Table_0344_FL_1425_B.txt 
                 12,018,656 
                 Aug. 16, 2004 
               
               
                 345 
                 Table_0345_FL_1426_A.txt 
                 12,156,576 
                 Aug. 12, 2004 
               
               
                 346 
                 Table_0346_FL_1426_B.txt 
                 12,009,428 
                 Aug. 16, 2004 
               
               
                 347 
                 Table_0347_FL_1427_A.txt 
                 11,984,418 
                 Aug. 13, 2004 
               
               
                 348 
                 Table_0348_FL_1427_B.txt 
                 11,739,570 
                 Aug. 16, 2004 
               
               
                 349 
                 Table_0349_FL_1428_A.txt 
                 12,158,088 
                 Aug. 16, 2004 
               
               
                 350 
                 Table_0350_FL_1428_B;txt 
                 11,971,322 
                 Aug. 13, 2004 
               
               
                 351 
                 Table_0351_FL_1429_A.txt 
                 11,886,842 
                 Aug. 13, 2004 
               
               
                 352 
                 Table_0352_FL_1429_B.txt 
                 11,785,560 
                 Aug. 13, 2004 
               
               
                 353 
                 Table_0353_FL_1432_A.txt 
                 11,936,050 
                 Aug. 13, 2004 
               
               
                 354 
                 Table_0354_FL_1432_B.txt 
                 11,718,155 
                 Aug. 16, 2004 
               
               
                 355 
                 Table_0355_FL_1436_A.txt 
                 12,095,379 
                 Aug. 16, 2004 
               
               
                 356 
                 Table_0356_FL_1436_B.txt 
                 11,970,436 
                 Aug. 13, 2004 
               
               
                 357 
                 Table_0357_FL_1440_A.txt 
                 12,133,947 
                 Aug. 16, 2004 
               
               
                 358 
                 Table_0358_FL_1440_B.txt 
                 11,797,142 
                 Aug. 16, 2004 
               
               
                 359 
                 Table_0359_FL_1445_A.txt 
                 12,110,202 
                 Aug. 16, 2004 
               
               
                 360 
                 Table_0360_FL_1445_B.txt 
                 11,848,178 
                 Aug. 16, 2004 
               
               
                 361 
                 Table_0361_FL_1450_A.txt 
                 12,106,422 
                 Aug. 16, 2004 
               
               
                 362 
                 Table_0362_FL_1450_B.txt 
                 11,943,968 
                 Aug. 12, 2004 
               
               
                 363 
                 Table_0363_FL_1472_A.txt 
                 12,212,076 
                 Aug. 13, 2004 
               
               
                 364 
                 Table_0364_FL_1472_B.txt 
                 12,036,719 
                 Aug. 16, 2004 
               
               
                 365 
                 Table_0365_FL_1473_A.txt 
                 12,221,319 
                 Aug. 13, 2004 
               
               
                 366 
                 Table_0366_FL_1473_B.txt 
                 12,071,897 
                 Aug. 13, 2004 
               
               
                 367 
                 Table_0367_FL_1474_A.txt 
                 12,150,017 
                 Aug. 12, 2004 
               
               
                 368 
                 Table_0368_FL_1474_B.txt 
                 11,998,046 
                 Aug. 16, 2004 
               
               
                 369 
                 Table_0369_FL_1476_A.txt 
                 12,125,076 
                 Aug. 16, 2004 
               
               
                 370 
                 Table_0370_FL_1476_B.txt 
                 11,895,072 
                 Aug. 13, 2004 
               
               
                 371 
                 Table_0371_FL_1477_A.txt 
                 12,017,848 
                 Aug. 16, 2004 
               
               
                 372 
                 Table_0372_FL_1477_B.txt 
                 11,864,262 
                 Aug. 16, 2004 
               
               
                 373 
                 Table_0373_FL_1478_A.txt 
                 11,952,576 
                 Aug. 13, 2004 
               
               
                 374 
                 Table_0374_FL_1478_B.txt 
                 11,803,675 
                 Aug. 16, 2004 
               
               
                 375 
                 Table_0375_FL_1479_A.txt 
                 12,010,188 
                 Aug. 13, 2004 
               
               
                 376 
                 Table_0376_FL_1479_B.txt 
                 11,818,187 
                 Aug. 16, 2004 
               
               
                 377 
                 Table_0377_FL_1480_A.txt 
                 11,988,630 
                 Aug. 13, 2004 
               
               
                 378 
                 Table_0378_FL_1480_B.txt 
                 11,730,265 
                 Aug. 13, 2004 
               
               
                 379 
                 Table_0379_FL_1579_A.txt 
                 12,081,097 
                 Aug. 13, 2004 
               
               
                 380 
                 Table_0380_FL_1579_B.txt 
                 11,905,139 
                 Aug. 13, 2004 
               
               
                 381 
                 Table_0381_FL_1580_A.txt 
                 12,135,862 
                 Aug. 12, 2004 
               
               
                 382 
                 Table_0382_FL_1580_B.txt 
                 11,949,530 
                 Aug. 16, 2004 
               
               
                 383 
                 Table_0383_FL_1581_A.txt 
                 12,108,683 
                 Aug. 13, 2004 
               
               
                 384 
                 Table_0384_FL_1581_B.txt 
                 1,883,016 
                 Aug. 13, 2004 
               
               
                 385 
                 Table_0385_FL_1582_A.txt 
                 12,176,104 
                 Aug. 13, 2004 
               
               
                 386 
                 Table_0386_FL_1582_B.txt 
                 11,970,276 
                 Aug. 16, 2004 
               
               
                 387 
                 Table_0387_FL_1583_A.txt 
                 12,078,610 
                 Aug. 16, 2004 
               
               
                 388 
                 Table_0388_FL_1583_B.txt 
                 11,871,179 
                 Aug. 13, 2004 
               
            
           
           
               
            
               
                 Disc 8 of 22 
               
            
           
           
               
               
               
               
            
               
                 389 
                 Table_0389_FL_1584_A.txt 
                 12,169,682 
                 Aug. 13, 2004 
               
               
                 390 
                 Table_0390_FL_1584_B.txt 
                 12,035,358 
                 Aug. 16, 2004 
               
               
                 391 
                 Table_0391_FL_1585_A.txt 
                 12,228,755 
                 Aug. 13, 2004 
               
               
                 392 
                 Table_0392_FL_1585_B.txt 
                 11,995,646 
                 Aug. 13, 2004 
               
               
                 393 
                 Table_0393_FL_1586_A.txt 
                 12,133,764 
                 Aug. 16, 2004 
               
               
                 394 
                 Table_0394_FL_1586_B.txt 
                 11,897,600 
                 Aug. 16, 2004 
               
               
                 395 
                 Table_0395_FL_1588_A.txt 
                 11,934,635 
                 Aug. 12, 2004 
               
               
                 396 
                 Table_0396_FL_1588_B.txt 
                 11,772,260 
                 Aug. 13, 2004 
               
               
                 397 
                 Table_0397_FL_1589_A.txt 
                 12,139,333 
                 Aug. 13, 2004 
               
               
                 398 
                 Table_0398_FL_1589_B.txt 
                 12,016,431 
                 Aug. 13, 2004 
               
               
                 399 
                 Table_0399_FL_1591_A.txt 
                 12,007,646 
                 Aug. 13, 2004 
               
               
                 400 
                 Table_0400_FL_1591_B.txt 
                 12,031,102 
                 Aug. 13, 2004 
               
               
                 401 
                 Table_0401_FL_1594_A.txt 
                 11,931,355 
                 Aug. 16, 2004 
               
               
                 402 
                 Table_0402_FL_1594_B.txt 
                 12,009,670 
                 Aug. 13, 2004 
               
               
                 403 
                 Table_0403_FL_1595_A.txt 
                 11,824,656 
                 Aug. 16, 2004 
               
               
                 404 
                 Table_0404_FL_1595_B.txt 
                 11,867,729 
                 Aug. 13, 2004 
               
               
                 405 
                 Table_0405_FL_1598_A.txt 
                 12,136,878 
                 Aug. 13, 2004 
               
               
                 406 
                 Table_0406_FL_1598_B.txt 
                 12,067,658 
                 Aug. 16, 2004 
               
               
                 407 
                 Table_0407_FL_1599_A.txt 
                 12,029,574 
                 Aug. 16, 2004 
               
               
                 408 
                 Table_0408_FL_1599_B.txt 
                 11,820,074 
                 Aug. 16, 2004 
               
               
                 409 
                 Table_0409_FL_1603_A.txt 
                 12,091,394 
                 Aug. 13, 2004 
               
               
                 410 
                 Table_0410_FL_1603_B.txt 
                 11,869,687 
                 Aug. 12, 2004 
               
               
                 411 
                 Table_0411_FL_1604_A.txt 
                 12,027,557 
                 Aug. 16, 2004 
               
               
                 412 
                 Table_0412_FL_1604_B.txt 
                 11,817,875 
                 Aug. 13, 2004 
               
               
                 413 
                 Table_0413_FL_1606_A.txt 
                 12,068,506 
                 Aug. 13, 2004 
               
               
                 414 
                 Table_0414_FL_1606_B.txt 
                 11,902,253 
                 Aug. 13, 2004 
               
               
                 415 
                 Table_0415_FL_1607_A.txt 
                 12,088,022 
                 Aug. 13, 2004 
               
               
                 416 
                 Table_0416_FL_1607_B.txt 
                 11,942,795 
                 Aug. 16, 2004 
               
               
                 417 
                 Table_0417_FL_1608_A.txt 
                 12,051,428 
                 Aug. 16, 2004 
               
               
                 418 
                 Table_0418_FL_1608_B.txt 
                 11,758,034 
                 Aug. 16, 2004 
               
               
                 419 
                 Table_0419_FL_1610_A.txt 
                 12,164,325 
                 Aug. 13, 2004 
               
               
                 420 
                 Table_0420_FL_1610_B.txt 
                 11,884,041 
                 Aug. 16, 2004 
               
               
                 421 
                 Table_0421_FL_1611_A.txt 
                 12,052,511 
                 Aug. 16, 2004 
               
               
                 422 
                 Table_0422_FL_1611_B.txt 
                 11,821,581 
                 Aug. 13, 2004 
               
               
                 423 
                 Table_0423_FL_1616_A.txt 
                 12,183,189 
                 Aug. 16, 2004 
               
               
                 424 
                 Table_0424_FL_1616_B.txt 
                 11,967,672 
                 Aug. 12, 2004 
               
               
                 425 
                 Table_0425_FL_1617_A.txt 
                 12,059,647 
                 Aug. 13, 2004 
               
               
                 426 
                 Table_0426_FL_1617_B.txt 
                 11,857,787 
                 Aug. 13, 2004 
               
               
                 427 
                 Table_0427_FL_1619_A.txt 
                 12,145,748 
                 Aug. 13, 2004 
               
               
                 428 
                 Table_0428_FL_1619_B.txt 
                 12,010,810 
                 Aug. 16, 2004 
               
               
                 429 
                 Table_0429_FL_1620_A.txt 
                 12,151,309 
                 Aug. 16, 2004 
               
               
                 430 
                 Table_0430_FL_1620_B.txt 
                 11,970,646 
                 Aug. 13, 2004 
               
               
                 431 
                 Table_0431_FL_1622_A.txt 
                 12,153,195 
                 Aug. 13, 2004 
               
               
                 432 
                 Table_0432_FL_1622_B.txt 
                 12,003,231 
                 Aug. 13, 2004 
               
               
                 433 
                 Table_0433_FL_1623_A.txt 
                 12,252,791 
                 Aug. 16, 2004 
               
               
                 434 
                 Table_0434_FL_1623_B.txt 
                 12,120,904 
                 Aug. 16, 2004 
               
               
                 435 
                 Table_0435_FL_1624_A.txt 
                 12,175,743 
                 Aug. 13, 2004 
               
               
                 436 
                 Table_0436_FL_1624_B.txt 
                 12,146,244 
                 Aug. 13, 2004 
               
               
                 437 
                 Table_0437_FL_1625_A.txt 
                 12,212,124 
                 Aug. 13, 2004 
               
               
                 438 
                 Table_0438_FL_1625_B.txt 
                 12,042,056 
                 Aug. 13, 2004 
               
               
                 439 
                 Table_0439_FL_1626_A.txt 
                 12,180,263 
                 Aug. 13, 2004 
               
               
                 440 
                 Table_0440_FL_1626_B.txt 
                 12,013,477 
                 Aug. 16, 2004 
               
               
                 441 
                 Table_0441_FL_1627_A.txt 
                 12,168,379 
                 Aug. 13, 2004 
               
               
                 442 
                 Table_0442_FL_1627_B.txt 
                 12,025,929 
                 Aug. 13, 2004 
               
               
                 443 
                 Table_0443_FL_1628_A.txt 
                 12,164,556 
                 Aug. 13, 2004 
               
               
                 444 
                 Table_0444_FL_1628_B.txt 
                 11,605,629 
                 Aug. 13, 2004 
               
            
           
           
               
            
               
                 Disc 9 of 22 
               
            
           
           
               
               
               
               
            
               
                 445 
                 Table_0445_FL_1637_A.txt 
                 12,059,851 
                 Aug. 13, 2004 
               
               
                 446 
                 Table_0446_FL_1637_B.txt 
                 11,851,760 
                 Aug. 16, 2004 
               
               
                 447 
                 Table_0447_FL_1638_A.txt 
                 12,155,584 
                 Aug. 12, 2004 
               
               
                 448 
                 Table_0448_FL_1638_B.txt 
                 11,953,771 
                 Aug. 13, 2004 
               
               
                 449 
                 Table_0449_FL_1639_A.txt 
                 12,104,432 
                 Aug. 13, 2004 
               
               
                 450 
                 Table_0450_FL_1639_B.txt 
                 11,885,752 
                 Aug. 16, 2004 
               
               
                 451 
                 Table_0451_FL_1643_A.txt 
                 12,113,590 
                 Aug. 16, 2004 
               
               
                 452 
                 Table_0452_FL_1643_B.txt 
                 11,976,289 
                 Aug. 16, 2004 
               
               
                 453 
                 Table_0453_FL_1644_A.txt 
                 12,135,052 
                 Aug. 16, 2004 
               
               
                 454 
                 Table_0454_FL_1644_B.txt 
                 11,864,285 
                 Aug. 13, 2004 
               
               
                 455 
                 Table_0455_FL_1645_A.txt 
                 12,082,408 
                 Aug. 13, 2004 
               
               
                 456 
                 Table_0456_FL_1645_B.txt 
                 11,794,548 
                 Aug. 16, 2004 
               
               
                 457 
                 Table_0457_FL_1646_A.txt 
                 12,205,460 
                 Aug. 16, 2004 
               
               
                 458 
                 Table_0458_FL_1646_B.txt 
                 12,063,381 
                 Aug. 13, 2004 
               
               
                 459 
                 Table_0459_FL_1647_A.txt 
                 12,014,730 
                 Aug. 16, 2004 
               
               
                 460 
                 Table_0460_FL_1647_B.txt 
                 11,815,426 
                 Aug. 13, 2004 
               
               
                 461 
                 Table_0461_FL_1648_A.txt 
                 12,129,890 
                 Aug. 13, 2004 
               
               
                 462 
                 Table_0462_FL_1648_B.txt 
                 11,970,207 
                 Aug. 13, 2004 
               
               
                 463 
                 Table_0463_FL_1652_A.txt 
                 12,094,102 
                 Aug. 16, 2004 
               
               
                 464 
                 Table_0464_FL_1652_B.txt 
                 11,858,393 
                 Aug. 12, 2004 
               
               
                 465 
                 Table_0465_FL_1654_A.txt 
                 12,054,434 
                 Aug. 16, 2004 
               
               
                 466 
                 Table_0466_FL_1654_B.txt 
                 11,835,533 
                 Aug. 13, 2004 
               
               
                 467 
                 Table_0467_FL_1655_A.txt 
                 12,011,007 
                 Aug. 12, 2004 
               
               
                 468 
                 Table_0468_FL_1655_B.txt 
                 11,839,935 
                 Aug. 12, 2004 
               
               
                 469 
                 Table_0469_FL_1656_A.txt 
                 11,998,067 
                 Aug. 16, 2004 
               
               
                 470 
                 Table_0470_FL_1656_B.txt 
                 11,783,615 
                 Aug. 13, 2004 
               
               
                 471 
                 Table_0471_FL_1657_A.txt 
                 12,095,831 
                 Aug. 13, 2004 
               
               
                 472 
                 Table_0472_FL_1657_B.txt 
                 11,872,675 
                 Aug. 12, 2004 
               
               
                 473 
                 Table_0473_FL_1660_A.txt 
                 11,984,440 
                 Aug. 13, 2004 
               
               
                 474 
                 Table_0474_FL_1660_B.txt 
                 11,793,957 
                 Aug. 16, 2004 
               
               
                 475 
                 Table_0475_FL_1661_A.txt 
                 12,115,368 
                 Aug. 13, 2004 
               
               
                 476 
                 Table_0476_FL_1661_B.txt 
                 11,907,640 
                 Aug. 16, 2004 
               
               
                 477 
                 Table_0477_FL_1662_A.txt 
                 11,935,841 
                 Aug. 13, 2004 
               
               
                 478 
                 Table_0478_FL_1662_B.txt 
                 11,655,368 
                 Aug. 16, 2004 
               
               
                 479 
                 Table_0479_FL_1664_A.txt 
                 12,057,315 
                 Aug. 13, 2004 
               
               
                 480 
                 Table_0480_FL_1664_B.txt 
                 11,881,016 
                 Aug. 13, 2004 
               
               
                 481 
                 Table_0481_FL_1669_A.txt 
                 12,067,483 
                 Aug. 16, 2004 
               
               
                 482 
                 Table_0482_FL_1669_B.txt 
                 11,942,861 
                 Aug. 13, 2004 
               
               
                 483 
                 Table_0483_FL_1670_A.txt 
                 12,037,021 
                 Aug. 16, 2004 
               
               
                 484 
                 Table_0484_FL_1670_B.txt 
                 11,862,504 
                 Aug. 13, 2004 
               
               
                 485 
                 Table_0485_FL_1675_A.txt 
                 12,062,632 
                 Aug. 16, 2004 
               
               
                 486 
                 Table_0486_FL_1675_B.txt 
                 11,823,358 
                 Aug. 13, 2004 
               
               
                 487 
                 Table_0487_FL_1681_A.txt 
                 11,978,013 
                 Aug. 13, 2004 
               
               
                 488 
                 Table_0488_FL_1681_B.txt 
                 11,745,731 
                 Aug. 16, 2004 
               
               
                 489 
                 Table_0489_FL_1883_A.txt 
                 11,919,352 
                 Aug. 12, 2004 
               
               
                 490 
                 Table_0490_FL_1683_B.txt 
                 11,780,543 
                 Aug. 12, 2004 
               
               
                 491 
                 Table_0491_FL_1684_A.txt 
                 12,186,541 
                 Aug. 13, 2004 
               
               
                 492 
                 Table_0492_FL_1684_B.txt 
                 12,056,872 
                 Aug. 13, 2004 
               
               
                 493 
                 Table_0493_FL_1716_A.txt 
                 12,160,373 
                 Aug. 16, 2004 
               
               
                 494 
                 Table_0494_FL_1716_B.txt 
                 11,995,492 
                 Aug. 13, 2004 
               
               
                 495 
                 Table_0495_FL_1717_A.txt 
                 11,938,675 
                 Aug. 13, 2004 
               
               
                 496 
                 Table_0496_FL_1717_B.txt 
                 11,950,078 
                 Aug. 12, 2004 
               
               
                 497 
                 Table_0497_FL_1718_A.txt 
                 12,102,928 
                 Aug. 12, 2004 
               
               
                 498 
                 Table_0498_FL_1718_B.txt 
                 1,946,324 
                 Aug. 12, 2004 
               
               
                 499 
                 Table_0499_FL_1719_A.txt 
                 11,980,431 
                 Aug. 16, 2004 
               
               
                 500 
                 Table_0500_FL_1719_B.txt 
                 11,941,393 
                 Aug. 13, 2004 
               
               
                 501 
                 Table_0501_FL_1720_A.txt 
                 11,957,606 
                 Aug. 31, 2004 
               
               
                 502 
                 Table_0502_FL_1720_B.txt 
                 11,790,878 
                 Aug. 31, 2004 
               
               
                 503 
                 Table_0503_FL_1729_A.txt 
                 12,015,501 
                 Aug. 31, 2004 
               
               
                 504 
                 Table_0504_FL_1729_B.txt 
                 12,003,112 
                 Aug. 31, 2004 
               
            
           
           
               
            
               
                 Disc 10 of 22 
               
            
           
           
               
               
               
               
            
               
                 505 
                 Table_0505_FL_1732_A.txt 
                 12,019,768 
                 Aug. 31, 2004 
               
               
                 506 
                 Table_0506_FL_1732_B.txt 
                 11,937,384 
                 Aug. 31, 2004 
               
               
                 507 
                 Table_0507_FL_1735_A.txt 
                 12,229,281 
                 Aug. 31, 2004 
               
               
                 508 
                 Table_0508_FL_1735_B.txt 
                 12,010,813 
                 Aug. 31, 2004 
               
               
                 509 
                 Table_0509_FL_1761_A.txt 
                 12,013,113 
                 Aug. 31, 2004 
               
               
                 510 
                 Table_0510_FL_1761_B.txt 
                 11,84S,381 
                 Aug. 31, 2004 
               
               
                 511 
                 Table_0511_FL_1764_A.txt 
                 12,072,874 
                 Aug. 31, 2004 
               
               
                 512 
                 Table_0512_FL_1764_B.txt 
                 12,067,878 
                 Aug. 31, 2004 
               
               
                 513 
                 Table_0513_FL_1768_A.txt 
                 12,164,392 
                 Aug. 31, 2004 
               
               
                 514 
                 Table_0514_FL_1768_B.txt 
                 12,159,717 
                 Aug. 31, 2004 
               
               
                 515 
                 Table_0515_FL_1771_A.txt 
                 12,171,432 
                 Aug. 31, 2004 
               
               
                 516 
                 Table_0516_FL_1771_B.txt 
                 11,981,937 
                 Aug. 31, 2004 
               
               
                 517 
                 Table_0517_FL_1772_A.txt 
                 12,099,592 
                 Aug. 31, 2004 
               
               
                 518 
                 Table_0518_FL_1772_B.txt 
                 12,044,119 
                 Aug. 31, 2004 
               
               
                 519 
                 Table_0519_FL_1788_A.txt 
                 12,057,485 
                 Aug. 31, 2004 
               
               
                 520 
                 Table_0520_FL_1788_B.txt 
                 12,000,622 
                 Aug. 31, 2004 
               
               
                 521 
                 Table_0521_FL_1790_A.txt 
                 11,866,178 
                 Aug. 13, 2004 
               
               
                 522 
                 Table_0522_FL_1790_B.txt 
                 11,879,605 
                 Aug. 16, 2004 
               
               
                 523 
                 Table_0523_FL_1792_A.txt 
                 12,107,831 
                 Aug. 12, 2004 
               
               
                 524 
                 Table_0524_FL_1792_B.txt 
                 11,981,731 
                 Aug. 16, 2004 
               
               
                 525 
                 Table_0525_FL_1795_A.txt 
                 12,147,382 
                 Aug. 13, 2004 
               
               
                 526 
                 Table_0526_FL_1795_B.txt 
                 12,027,851 
                 Aug. 13, 2004 
               
               
                 527 
                 Table_0527_FL_1797_A.txt 
                 12,007,290 
                 Aug. 16, 2004 
               
               
                 528 
                 Table_0528_FL_1797_B.txt 
                 11,977,859 
                 Aug. 13, 2004 
               
               
                 529 
                 Table_0529_FL_1799_A.txt 
                 12,136,510 
                 Aug. 13, 2004 
               
               
                 530 
                 Table_0530_FL_1799_B.txt 
                 12,019,206 
                 Aug. 16, 2004 
               
               
                 531 
                 Table_0531_FL_1810_A.txt 
                 12,086,662 
                 Aug. 13, 2004 
               
               
                 532 
                 Table_0532_FL_1810_B.txt 
                 11,977,958 
                 Aug. 16, 2004 
               
               
                 533 
                 Table_0533_FL_1811_A.txt 
                 12,122,670 
                 Aug. 16, 2004 
               
               
                 534 
                 Table_0534_FL_1811_B.txt 
                 11,929,935 
                 Aug. 13, 2004 
               
               
                 535 
                 Table_0535_FL_1825_A.txt 
                 11,967,784 
                 Aug. 13, 2004 
               
               
                 536 
                 Table_0536_FL_1825_B.txt 
                 11,932,434 
                 Aug. 12, 2004 
               
               
                 537 
                 Table_0537_FL_1827_A.txt 
                 11,955,058 
                 Aug. 13, 2004 
               
               
                 538 
                 Table_0538_FL_1827_B.txt 
                 11,969,116 
                 Aug. 13, 2004 
               
               
                 539 
                 Table_0539_FL_1828_A.txt 
                 12,029,099 
                 Aug. 12, 2004 
               
               
                 540 
                 Table_0540_FL_1828_B.txt 
                 11,877,005 
                 Aug. 13, 2004 
               
               
                 541 
                 Table_0541_FL_1829_A.txt 
                 12,014,127 
                 Aug. 13, 2004 
               
               
                 542 
                 Table_0542_FL_1829_B.txt 
                 11,885,190 
                 Aug. 12, 2004 
               
               
                 543 
                 Table_0543_FL_1830_A.txt 
                 12,089,030 
                 Aug. 13, 2004 
               
               
                 544 
                 Table_0544_FL_1830_B.txt 
                 11,935,691 
                 Aug. 13, 2004 
               
               
                 545 
                 Table_0545_FL_1833_A.txt 
                 12,162,920 
                 Aug. 16, 2004 
               
               
                 546 
                 Table_0546_FL_1833_B.txt 
                 11,990,591 
                 Aug. 13, 2004 
               
               
                 547 
                 Table_0547_FL_1834_A.txt 
                 11,952,185 
                 Aug. 13, 2004 
               
               
                 548 
                 Table_0548_FL_1834_B.txt 
                 11,906,810 
                 Aug. 12, 2004 
               
               
                 549 
                 Table_0549_FL_1835_A.txt 
                 12,122,553 
                 Aug. 13, 2004 
               
               
                 559 
                 Table_0550_FL_1835_B.txt 
                 12,017,691 
                 Aug. 12, 2004 
               
               
                 551 
                 Table_0551_FL_1836_A.txt 
                 12,187,532 
                 Aug. 13, 2004 
               
               
                 552 
                 Table_0552_FL_1836_B.txt 
                 12,063,526 
                 Aug. 16, 2004 
               
               
                 553 
                 Table_0553_FL_1837_A.txt 
                 12,044,450 
                 Aug. 16, 2004 
               
               
                 554 
                 Table_0554_FL_1837_B.txt 
                 1,945,547 
                 Aug. 16, 2004 
               
               
                 555 
                 Table_0555_FL_1038_A.txt 
                 12,024,726 
                 Aug. 13, 2004 
               
               
                 556 
                 Table_0556_FL_1838_B.txt 
                 11,908,269 
                 Aug. 16, 2004 
               
               
                 557 
                 Table_0557_FL_1839_A.txt 
                 12,063,812 
                 Aug. 16, 2004 
               
               
                 558 
                 Table_0558_FL_1839_B.txt 
                 11,957,591 
                 Aug. 13, 2004 
               
               
                 559 
                 Table_0559_FL_1841_A.txt 
                 12,137,503 
                 Aug. 13, 2004 
               
               
                 560 
                 Table_0560_FL_1841_B.txt 
                 11,977,376 
                 Aug. 13, 2004 
               
            
           
           
               
            
               
                 Disc 11 of 22 
               
            
           
           
               
               
               
               
            
               
                 561 
                 Table_0561_FL_1842_A.txt 
                 11,838,323 
                 Aug. 13, 2004 
               
               
                 562 
                 Table_0562_FL_1042_B.txt 
                 11,777,270 
                 Aug. 13, 2004 
               
               
                 563 
                 Table_0563_FL_1844_A.txt 
                 12,101,060 
                 Aug. 13, 2004 
               
               
                 564 
                 Table_0564_FL_1844_B.txt 
                 11,948,925 
                 Aug. 12, 2004 
               
               
                 565 
                 Table_0565_FL_1845_A.txt 
                 12,080,776 
                 Aug. 13, 2004 
               
               
                 566 
                 Table_0566_FL_1845_B.txt 
                 11,896,386 
                 Aug. 12, 2004 
               
               
                 567 
                 Table_0567_FL_1846_A.txt 
                 12,068,884 
                 Aug. 13, 2004 
               
               
                 568 
                 Table_0568_FL_1846_B.txt 
                 11,927,246 
                 Aug. 16, 2004 
               
               
                 569 
                 Table_0569_FL_1848_A.txt 
                 12,203,436 
                 Aug. 13, 2004 
               
               
                 570 
                 Table_0570_FL_1848_B.txt 
                 12,066,922 
                 Aug. 16, 2004 
               
               
                 571 
                 Table_0571_FL_1850_A.txt 
                 12,150,601 
                 Aug. 16, 2004 
               
               
                 572 
                 Table_0572_FL_1850_B.txt 
                 12,041,327 
                 Aug. 13, 2004 
               
               
                 573 
                 Table_0573_FL_1851_A.txt 
                 12,182,233 
                 Aug. 12, 2004 
               
               
                 574 
                 Table_0574_FL_1851_B.txt 
                 12,075,493 
                 Aug. 16, 2004 
               
               
                 575 
                 Table_0575_FL_1853_A.txt 
                 12,087,688 
                 Aug. 13, 2004 
               
               
                 576 
                 Table_0576_FL_1853_B.txt 
                 11,933,285 
                 Aug. 16, 2004 
               
               
                 577 
                 Table_0577_FL_1854_A.txt 
                 12,155,291 
                 Aug. 12, 2004 
               
               
                 578 
                 Table_0578_FL_1854_B.txt 
                 11,959,793 
                 Aug. 16, 2004 
               
               
                 579 
                 Table_0579_FL_1855_A.txt 
                 12,238,359 
                 Aug. 16, 2004 
               
               
                 580 
                 Table_0580_FL_1855_B.txt 
                 12,034,894 
                 Aug. 12, 2004 
               
               
                 581 
                 Table_0581_FL_1857_A.txt 
                 12,205,129 
                 Aug. 16, 2004 
               
               
                 582 
                 Table_0582_FL_1857_B.txt 
                 12,076,155 
                 Aug. 16, 2004 
               
               
                 583 
                 Table_0583_FL_1861_A.txt 
                 12,040,917 
                 Aug. 16, 2004 
               
               
                 584 
                 Table_0584_FL_1861_B.txt 
                 11,858,142 
                 Aug. 13, 2004 
               
               
                 585 
                 Table_0585_FL_1862_A.txt 
                 12,041,052 
                 Aug. 13, 2004 
               
               
                 585 
                 Table_0586_FL_1862_B.txt 
                 11,924,463 
                 Aug. 13, 2004 
               
               
                 587 
                 Table_0587_FL_1863_A.txt 
                 12,058,282 
                 Aug. 13, 2004 
               
               
                 588 
                 Table_0588_FL_1863_B.txt 
                 11,905,465 
                 Aug. 12, 2004 
               
               
                 589 
                 Table_0589_FL_1864_A.txt 
                 12,114,627 
                 Aug. 16, 2004 
               
               
                 590 
                 Table_0590_FL_1864_B.txt 
                 11,910,825 
                 Aug. 13, 2004 
               
               
                 591 
                 Table_0591_FL_1866_A.txt 
                 12,192,098 
                 Aug. 12, 2004 
               
               
                 592 
                 Table_0592_FL_1866_B.txt 
                 12,052,374 
                 Aug. 13, 2004 
               
               
                 593 
                 Table_0593_FL_1870_A.txt 
                 12,017,057 
                 Aug. 13, 2004 
               
               
                 594 
                 Table_0594_FL_1870_B.txt 
                 11,959,328 
                 Aug. 16, 2004 
               
               
                 595 
                 Table_0595_FL_1873_A.txt 
                 11,193,964 
                 Aug. 12, 2004 
               
               
                 596 
                 Table_0596_FL_1873_B.txt 
                 12,071,638 
                 Aug. 13, 2004 
               
               
                 597 
                 Table_0597_FL_1874_A.txt 
                 12,096,385 
                 Aug. 13, 2004 
               
               
                 598 
                 Table_0598_FL_1874_B.txt 
                 12,004,410 
                 Aug. 16, 2004 
               
               
                 599 
                 Table_0599_FL_1876_A.txt 
                 12,130,466 
                 Aug. 13, 2004 
               
               
                 600 
                 Table_0600_FL_1876_B.txt 
                 11,894,443 
                 Aug. 13, 2004 
               
               
                 601 
                 Table_0601_FL_1879_A.txt 
                 12,047,598 
                 Aug. 16, 2004 
               
               
                 602 
                 Table_0602_FL_1879_B.txt 
                 11,816,302 
                 Aug. 16, 2004 
               
               
                 603 
                 Table_0603_FL_1880_A.txt 
                 11,925,145 
                 Aug. 16, 2004 
               
               
                 604 
                 Table_0604_FL_1880_B.txt 
                 11,872,612 
                 Aug. 12, 2004 
               
               
                 605 
                 Table_0605_FL_1882_A.txt 
                 12,006,192 
                 Aug. 13, 2004 
               
               
                 696 
                 Table_0606_FL_1882_B.txt 
                 11,755,896 
                 Aug. 13, 2004 
               
               
                 607 
                 Table_0607_FL_1884_A.txt 
                 11,983,446 
                 Aug. 13, 2004 
               
               
                 608 
                 Table_0608_FL_1884_B.txt 
                 11,850,008 
                 Aug. 12, 2004 
               
               
                 609 
                 Table_0609_FL_1885_A.txt 
                 12,000,301 
                 Aug. 13, 2004 
               
               
                 610 
                 Table_0610_FL_1885_B.txt 
                 11,802,742 
                 Aug. 16, 2004 
               
               
                 611 
                 Table_0611_FL_1887_A.txt 
                 12,008,565 
                 Aug. 13, 2004 
               
               
                 612 
                 Table_0612_FL_1887_B.txt 
                 11,916,475 
                 Aug. 16, 2004 
               
               
                 613 
                 Table_0613_FL_1888_A.txt 
                 12,027,927 
                 Aug. 13, 2004 
               
               
                 614 
                 Table_0614_FL_1888_B.txt 
                 11,850,399 
                 Aug. 13, 2004 
               
               
                 615 
                 Table_0615_FL_1890_A.txt 
                 11,991,887 
                 Aug. 13, 2004 
               
               
                 616 
                 Table_0616_FL_1890_B.txt 
                 11,723,176 
                 Aug. 16, 2004 
               
               
                 617 
                 Table_0617_FL_1894_A.txt 
                 11,970,378 
                 Aug. 12, 2004 
               
               
                 618 
                 Table_0618_FL_1894_B.txt 
                 11,814,812 
                 Aug. 16, 2004 
               
               
                 619 
                 Table_0619_FL_1896_A.txt 
                 11,986,044 
                 Aug. 13, 2004 
               
               
                 620 
                 Table_0620_FL_1896_B.txt 
                 11,846,067 
                 Aug. 16, 2004 
               
               
                 621 
                 Table_0621_FL_1897_A.txt 
                 11,936,008 
                 Aug. 13, 2004 
               
            
           
           
               
            
               
                 Disc 12 of 22 
               
            
           
           
               
               
               
               
            
               
                 622 
                 Table_0622_FL_1897_B.txt 
                 11,766,595 
                 Aug. 16, 2004 
               
               
                 623 
                 Table_0623_FL_1898_A.txt 
                 12,044,053 
                 Aug. 16, 2004 
               
               
                 624 
                 Table_0624_FL_1898_B.txt 
                 11,886,226 
                 Aug. 13, 2004 
               
               
                 625 
                 Table_0625_FL_1900_A.txt 
                 11,950,630 
                 Aug. 13, 2004 
               
               
                 626 
                 Table_0626_FL_1900_B.txt 
                 11,714,418 
                 Aug. 13, 2004 
               
               
                 627 
                 Table_0627_FL_1903_A.txt 
                 12,114,153 
                 Aug. 13, 2004 
               
               
                 628 
                 Table_0628_FL_1903_B.txt 
                 11,971,160 
                 Aug. 13, 2004 
               
               
                 629 
                 Table_0629_FL_1904_A.txt 
                 12,005,503 
                 Aug. 12, 2004 
               
               
                 630 
                 Table_0630_FL_1904_B.txt 
                 11,844,302 
                 Aug. 13, 2004 
               
               
                 631 
                 Table_0631_FL_1905_A.txt 
                 12,001,380 
                 Aug. 13, 2004 
               
               
                 632 
                 Table_0632_FL_1905_B.txt 
                 11,761,255 
                 Aug. 16, 2004 
               
               
                 633 
                 Table_0633_FL_1906_A.txt 
                 11,942,117 
                 Aug. 13, 2904 
               
               
                 634 
                 Table_0634_FL_1906_B.txt 
                 11,733,601 
                 Aug. 13, 2004 
               
               
                 635 
                 Table_0635_FL_1907_A.txt 
                 11,966,185 
                 Aug. 16, 2004 
               
               
                 636 
                 Table_0636_FL_1907_B.txt 
                 11,824,403 
                 Aug. 16, 2004 
               
               
                 637 
                 Table_0637_FL_1910_A.txt 
                 12,086,740 
                 Aug. 16, 2004 
               
               
                 638 
                 Table_0638_FL_1910_B.txt 
                 11,975,275 
                 Aug. 13, 2004 
               
               
                 639 
                 Table_0639_FL_1912_A.txt 
                 12,103,924 
                 Aug. 13, 2004 
               
               
                 640 
                 Table_0640_FL_1912_B.txt 
                 11,961,340 
                 Aug. 13, 2004 
               
               
                 641 
                 Table_0641_FL_1913_A.txt 
                 12,113,471 
                 Aug. 12, 2004 
               
               
                 642 
                 Table_0642_FL_1913_B.txt 
                 11,876,693 
                 Aug. 13, Z004 
               
               
                 643 
                 Table_0643_FL_1916_A.txt 
                 12,083,419 
                 Aug. 12, 2004 
               
               
                 644 
                 Table_0644_FL_1916_B.txt 
                 11,867,823 
                 Aug. 16, 2004 
               
               
                 645 
                 Table_0645_FL_1918_A.txt 
                 12,100,679 
                 Aug. 13, 2004 
               
               
                 646 
                 Table_0646_FL_1918_B.txt 
                 11,752,183 
                 Aug. 16, 2004 
               
               
                 647 
                 Table_0647_FL_1919_A.txt 
                 11,911,303 
                 Aug. 13, 2004 
               
               
                 648 
                 Table_0648_FL_1919_B.txt 
                 11,746,064 
                 Aug. 16, 2004 
               
               
                 649 
                 Table_0649_GCB_412_A.txt 
                 12,159,887 
                 Aug. 16, 2004 
               
               
                 650 
                 Table_0650_GCB_412_B.txt 
                 11,936,122 
                 Aug. 16, 2004 
               
               
                 651 
                 Table_0651_GCB_415_A.txt 
                 12,127,395 
                 Aug. 13, 2004 
               
               
                 652 
                 Table_0652_GCB_415_B.txt 
                 11,974,456 
                 Aug. 13, 2004 
               
               
                 663 
                 Table_0653_GCB_421_A.txt 
                 12,089,656 
                 Aug. 12, 2004 
               
               
                 654 
                 Table_0654_GCB_421_B.txt 
                 11,977,458 
                 Aug. 13, 2004 
               
               
                 655 
                 Table_0655_GCB_424_A.txt 
                 12,234,103 
                 Aug. 12, 2004 
               
               
                 656 
                 Table_0656_GCB_424_B.txt 
                 11,982,465 
                 Aug. 12, 2004 
               
               
                 657 
                 Table_0657_GCB_433_A.txt 
                 12,281,184 
                 Aug. 16, 2004 
               
               
                 658 
                 Table_0658_GCB_433_B.txt 
                 12,083,431 
                 Aug. 13, 2004 
               
               
                 659 
                 Table_0659_GCB_434_A.txt 
                 12,293,242 
                 Aug. 13, 2004 
               
               
                 660 
                 Table_0660_GCB_434_B.txt 
                 12,107,279 
                 Aug. 16, 2004 
               
               
                 661 
                 Table_0661_GCB_438_A.txt 
                 12,221,161 
                 Aug. 16, 2004 
               
               
                 662 
                 Table_0662_GCB_438_B.txt 
                 12,019,388 
                 Aug. 13, 2004 
               
               
                 663 
                 Table_0663_GCB_439_A.txt 
                 11,992,537 
                 Aug. 13, 2004 
               
               
                 664 
                 Table_0664_GCB_439_B.txt 
                 11,899,300 
                 Aug. 16, 2004 
               
               
                 665 
                 Table_0665_GCB_459_A.txt 
                 12,290,334 
                 Aug. 16, 2004 
               
               
                 666 
                 Table_0666_GCB_459_B.txt 
                 12,042,592 
                 Aug. 12, 2004 
               
               
                 667 
                 Table_0667_GCB_470_A.txt 
                 12,105,369 
                 Aug. 13, 2004 
               
               
                 668 
                 Table_0668_GCB_470_B.txt 
                 11,860,994 
                 Aug. 16, 2004 
               
               
                 669 
                 Table_0669_GCB_479_A.txt 
                 11,959,122 
                 Aug. 16, 2004 
               
               
                 670 
                 Table_0870_GCB_479_B.txt 
                 11,939,440 
                 Aug. 13, 2004 
               
               
                 671 
                 Table_0671_GCB_492_A.txt 
                 12,215,479 
                 Aug. 16, 2004 
               
               
                 672 
                 Table_0672_GCB_492_B.txt 
                 11,973,889 
                 Aug. 13, 2004 
               
               
                 673 
                 Table_0673_GCB_517_A.txt 
                 12,123,982 
                 Aug. 16, 2004 
               
               
                 674 
                 Table_0674_GCB_517_B.txt 
                 11,944,186 
                 Aug. 13, 2004 
               
               
                 675 
                 Table_0675_GCB_523_A.txt 
                 12,154,045 
                 Aug. 16, 2004 
               
               
                 676 
                 Table_0676_GCB_523_B.txt 
                 12,048,726 
                 Aug. 13, 2004 
               
               
                 677 
                 Table_0677_GCB_524_A.txt 
                 12,128,784 
                 Aug. 16, 2004 
               
               
                 678 
                 Table_0678_GCB_524_B.txt 
                 12,079,921 
                 Aug. 16, 2004 
               
               
                 679 
                 Table_0679_GCB_529_A.txt 
                 12,295,640 
                 Aug. 12, 2004 
               
               
                 680 
                 Table_0680_GCB_529_B.txt 
                 12,053,344 
                 Aug. 13, 2004 
               
               
                 681 
                 Table_0681_GCB_533_A.txt 
                 12,048,079 
                 Aug. 12, 2004 
               
               
                 682 
                 Table_0682_GCB_533_B.txt 
                 11,849,351 
                 Aug. 16, 2004 
               
            
           
           
               
            
               
                 Disc 13 of 22 
               
            
           
           
               
               
               
               
            
               
                 683 
                 Table_0683_GCB_537_A.txt 
                 12,151,426 
                 Aug. 16, 2004 
               
               
                 684 
                 Table_0684_GCB_537_B.txt 
                 12,017,692 
                 Aug. 16, 2004 
               
               
                 685 
                 Table_0685_GCB_543_A.txt 
                 12,163,497 
                 Aug. 13, 2004 
               
               
                 686 
                 Table_0686_GCB_543_B.txt 
                 11,981,555 
                 Aug. 13, 2004 
               
               
                 687 
                 Table_0687_GCB_545_A.txt 
                 12,102,161 
                 Aug. 12, 2004 
               
               
                 688 
                 Table_0688_GCB_545_B.txt 
                 11,881,457 
                 Aug. 13, 2004 
               
               
                 689 
                 Table_0689_GCB_549_A.txt 
                 12,161,840 
                 Aug. 13, 2004 
               
               
                 690 
                 Table_0690_GCB_549_B.txt 
                 12,020,632 
                 Aug. 13, 2004 
               
               
                 691 
                 Table_0691_GCB_550_A.txt 
                 12,171,880 
                 Aug. 12, 2004 
               
               
                 692 
                 Table_0692_GCB_550_B.txt 
                 11,944,012 
                 Aug. 13, 2004 
               
               
                 693 
                 Table_0693_GCB_553_A.txt 
                 12,111,245 
                 Aug. 16, 2004 
               
               
                 694 
                 Table_0694_GCB_553_B.txt 
                 11,864,058 
                 Aug. 13, 2004 
               
               
                 695 
                 Table_0695_GCB_565_A.txt 
                 12,063,661 
                 Aug. 13, 2004 
               
               
                 696 
                 Table_0696_GCB_565_B.txt 
                 11,965,851 
                 Aug. 13, 2004 
               
               
                 697 
                 Table_0697_GCB_572_A.txt 
                 12,108,923 
                 Aug. 16, 2004 
               
               
                 698 
                 Table_0698_GCB_572_B.txt 
                 11,888,114 
                 Aug. 16, 2004 
               
               
                 699 
                 Table_0699_GCB_617_A.txt 
                 12,130,626 
                 Aug. 13, 2004 
               
               
                 700 
                 Table_0700_GCB_617_B.txt 
                 11,901,308 
                 Aug. 13, 2004 
               
               
                 701 
                 Table_0701_GCB_618_A.txt 
                 12,190,874 
                 Aug. 12, 2004 
               
               
                 702 
                 Table_0702_GCB_618_B.txt 
                 11,980,754 
                 Aug. 16, 2004 
               
               
                 703 
                 Table_0703_GCB_619_A.txt 
                 12,140,602 
                 Aug. 13, 2004 
               
               
                 704 
                 Table_0704_GCB_619_B.txt 
                 11,905,019 
                 Aug. 16, 2004 
               
               
                 705 
                 Table_0705_GCB_623_A.txt 
                 12,265,682 
                 Aug. 13, 2004 
               
               
                 706 
                 Table_0706_GCB_623_B.txt 
                 12,090,817 
                 Aug. 13, 2004 
               
               
                 707 
                 Table_0707_GCB_627_A.txt 
                 12,173,309 
                 Aug. 16, 2004 
               
               
                 708 
                 Table_0708_GCB_627_B.txt 
                 11,958,281 
                 Aug. 16, 2004 
               
               
                 709 
                 Table_0709_GCB_654_A.txt 
                 12,127,035 
                 Aug. 13, 2004 
               
               
                 710 
                 Table_0710_GCB_654_B.txt 
                 11,929,393 
                 Aug. 16, 2004 
               
               
                 711 
                 Table_0711_GCB_661_A.txt 
                 12,192,238 
                 Aug. 12, 2004 
               
               
                 712 
                 Table_0712_GCB_661_B.txt 
                 12,030,163 
                 Aug. 13, 2004 
               
               
                 713 
                 Table_0713_GCB_669_A.txt 
                 12,273,029 
                 Aug. 16, 2004 
               
               
                 714 
                 Table_0714_GCB_669_B.txt 
                 12,103,510 
                 Aug. 12, 2004 
               
               
                 715 
                 Table_0715_GCB_672_A.txt 
                 12,146,779 
                 Aug. 13, 2004 
               
               
                 716 
                 Table_0716_GCB_672_B.txt 
                 11,942,479 
                 Aug. 13, 2004 
               
               
                 717 
                 Table_0717_GCB_674_A.txt 
                 12,096,808 
                 Aug. 13, 2004 
               
               
                 718 
                 Table_0718_GCB_674_B.txt 
                 11,907,095 
                 Aug. 13, 2004 
               
               
                 719 
                 Table_0719_GCB_675_A.txt 
                 12,026,251 
                 Aug. 16, 2004 
               
               
                 720 
                 Table_0720_GCB_675_B.txt 
                 11,875,031 
                 Aug. 13, 2004 
               
               
                 721 
                 Table_0721_GCB_681_A.txt 
                 12,218,121 
                 Aug. 16, 2004 
               
               
                 722 
                 Table_0722_GCB_681_B.txt 
                 12,001,615 
                 Aug. 13, 2004 
               
               
                 723 
                 Table_0723_GCB_688_A.txt 
                 12,228,824 
                 Aug. 16, 2004 
               
               
                 724 
                 Table_0724_GCB_688_B.txt 
                 11,984,738 
                 Aug. 13, 2004 
               
               
                 725 
                 Table_0725_GCB_695_A.txt 
                 12,239,383 
                 Aug. 13, 2004 
               
               
                 726 
                 Table_0726_GCB_695_B.txt 
                 12,064,067 
                 Aug. 13, 2004 
               
               
                 727 
                 Table_0727_GCB_698_A.txt 
                 12,041,776 
                 Aug. 13, 2004 
               
               
                 728 
                 Table_0728_GCB_698_B.txt 
                 11,913,341 
                 Aug. 13, 2004 
               
               
                 729 
                 Table_0729_GCB_701_A.txt 
                 12,052,305 
                 Aug. 13, 2004 
               
               
                 730 
                 Table_0730_GCB_701_B.txt 
                 11,822,784 
                 Aug. 12, 2004 
               
               
                 731 
                 Table_0731_GCB_710_A.txt 
                 12,150,765 
                 Aug. 13, 2004 
               
               
                 732 
                 Table_0732_GCB_710_B.txt 
                 11,950,813 
                 Aug. 12, 2004 
               
               
                 733 
                 Table_0733_GCB_711_A.txt 
                 12,132,273 
                 Aug. 12, 2004 
               
               
                 734 
                 Table_0734_GCB_711_B.txt 
                 11,858,885 
                 Aug. 13, 2004 
               
               
                 735 
                 Table_0735_GCB_722_A.txt 
                 12,154,845 
                 Aug. 13, 2004 
               
               
                 736 
                 Table_0736_GCB_722_B.txt 
                 11,985,108 
                 Aug. 13, 2004 
               
               
                 737 
                 Table_0737_GCB_724_A.txt 
                 12,146,329 
                 Aug. 12, 2004 
               
               
                 738 
                 Table_0738_GCB_724_B.txt 
                 11,887,755 
                 Aug. 13, 2004 
               
            
           
           
               
            
               
                 Disc 14 of 22 
               
            
           
           
               
               
               
               
            
               
                 739 
                 Table_0739_GCB_731_A.txt 
                 12,126,039 
                 Aug. 13, 2004 
               
               
                 740 
                 Table_0740_GCB_731_B.txt 
                 11,973,046 
                 Aug. 13, 2004 
               
               
                 741 
                 Table_0741_GCB_742_A.txt 
                 12,278,477 
                 Aug. 12, 2004 
               
               
                 742 
                 Table_0742_GCB_742_B.txt 
                 12,060,190 
                 Aug. 12, 2004 
               
               
                 743 
                 Table_0743_GCB_744_A.txt 
                 12,204,260 
                 Aug. 13, 2004 
               
               
                 744 
                 Table_0744_GCB_744_B.txt 
                 12,068,199 
                 Aug. 13, 2004 
               
               
                 745 
                 Table_0745_GCB_745_A.txt 
                 12,051,759 
                 Aug. 12, 2004 
               
               
                 746 
                 Table_0746_GCB_745_B.txt 
                 11,873,505 
                 Aug. 13, 2004 
               
               
                 747 
                 Table_0747_GCB_747_A.txt 
                 12,216,121 
                 Aug. 12, 2004 
               
               
                 748 
                 Table_0748_GCB_747_B.txt 
                 12,053,883 
                 Aug. 12, 2004 
               
               
                 749 
                 Table_0749_GCB_749_A.txt 
                 12,177,049 
                 Aug. 13, 2004 
               
               
                 750 
                 Table_0750_GCB_749_B.txt 
                 11,994,174 
                 Aug. 12, 2004 
               
               
                 751 
                 Table_0751_GCB_758_A.txt 
                 12,068,828 
                 Aug. 12, 2004 
               
               
                 752 
                 Table_0752_GCB_758_B.txt 
                 11,949,711 
                 Aug. 12, 2004 
               
               
                 753 
                 Table_0753_GCB_772_A.txt 
                 12,075,532 
                 Aug. 12, 2004 
               
               
                 754 
                 Table_0754_GCB_772_B.txt 
                 11,838,179 
                 Aug. 12, 2004 
               
               
                 755 
                 Table_0755_GCB_777_A.txt 
                 12,103,965 
                 Aug. 13, 2004 
               
               
                 756 
                 Table_0756_GCB_777_B.txt 
                 11,960,816 
                 Aug. 13, 2004 
               
               
                 757 
                 Table_0757_GCB_792_A.txt 
                 12,219,173 
                 Aug. 12, 2004 
               
               
                 758 
                 Table_0758_GCB_792_B.txt 
                 11,971,063 
                 Aug. 12, 2004 
               
               
                 759 
                 Table_0759_GCB_795_A.txt 
                 12,060,906 
                 Aug. 13, 2004 
               
               
                 760 
                 Table_0760_GCB_795_B.txt 
                 11,854,024 
                 Aug. 12, 2004 
               
               
                 761 
                 Table_0761_GCB_797_A.txt 
                 12,139,552 
                 Aug. 12, 2004 
               
               
                 762 
                 Table_0762_GCB_797_B.txt 
                 11,876,726 
                 Aug. 13, 2004 
               
               
                 763 
                 Table_0763_GCB_803_A.txt 
                 12,082,131 
                 Aug. 13, 2004 
               
               
                 764 
                 Table_0764_GCB_803_B.txt 
                 11,884,112 
                 Aug. 12, 2004 
               
               
                 765 
                 Table_0765_GCB_810_A.txt 
                 12,105,907 
                 Aug. 12, 2004 
               
               
                 766 
                 Table_0766_GCB_810_B.txt 
                 11,939,716 
                 Aug. 12, 2004 
               
               
                 767 
                 Table_0767_GCB_817_A.txt 
                 12,130,570 
                 Aug. 12, 2004 
               
               
                 768 
                 Table_0768_GCB_817_B.txt 
                 11,987,031 
                 Aug. 12, 2004 
               
               
                 769 
                 Table_0769_GCB_818_A.txt 
                 12,106,200 
                 Aug. 12, 2004 
               
               
                 770 
                 Table_0770_GCB_818_B.txt 
                 11,871,105 
                 Aug. 13, 2004 
               
               
                 771 
                 Table_0771_GCB_819_A.txt 
                 12,086,504 
                 Aug. 13, 2004 
               
               
                 772 
                 Table_0772_GCB_819_B.txt 
                 11,897,319 
                 Aug. 12, 2004 
               
               
                 773 
                 Table_0773_GCB_821_A.txt 
                 12,064,950 
                 Aug. 13, 2004 
               
               
                 774 
                 Table_0774_GCB_821_B.txt 
                 11,958,861 
                 Aug. 12, 2004 
               
               
                 775 
                 Table_0775_GCB_832_A.txt 
                 12,068,809 
                 Aug. 12, 2004 
               
               
                 776 
                 Table_0776_GCB_832_B.txt 
                 11,964,104 
                 Aug. 13, 2004 
               
               
                 777 
                 Table_0777_GCB_836_A.txt 
                 12,171,469 
                 Aug. 13, 2004 
               
               
                 778 
                 Table_0778_GCB_836_B.txt 
                 11,996,845 
                 Aug. 13, 2004 
               
               
                 779 
                 Table_0779_GCB_840_A.txt 
                 12,038,865 
                 Aug. 12, 2004 
               
               
                 780 
                 Table_0780_GCB_840_B.txt 
                 11,799,648 
                 Aug. 12, 2004 
               
               
                 781 
                 Table_0781_GCB_847_A.txt 
                 12,084,291 
                 Aug. 13, 2004 
               
               
                 782 
                 Table_0782_GCB_847_B.txt 
                 11,950,648 
                 Aug. 13, 2004 
               
               
                 783 
                 Table_0783_GCB_1005_A.txt 
                 12,100,992 
                 Aug. 13, 2004 
               
               
                 784 
                 Table_0784_GCB_1005_B.txt 
                 11,961,124 
                 Aug. 12, 2004 
               
               
                 785 
                 Table_0785_GCB_1008_A.txt 
                 12,084,812 
                 Aug. 13, 2004 
               
               
                 786 
                 Table_0786_GCB_1008_B.txt 
                 11,995,015 
                 Aug. 13, 2004 
               
               
                 787 
                 Table_0787_GCB_1009_A.txt 
                 11,943,142 
                 Aug. 13, 2004 
               
               
                 788 
                 Table_0788_GCB_1009_B.txt 
                 11,924,190 
                 Aug. 13, 2004 
               
               
                 789 
                 Table_0789_GCB_1021_A.txt 
                 12,113,951 
                 Aug. 13, 2004 
               
               
                 790 
                 Table_0790_GCB_1021_B.txt 
                 11,934,678 
                 Aug. 13, 2004 
               
               
                 791 
                 Table_0791_GCB_1025_A.txt 
                 12,101,376 
                 Aug. 12, 2004 
               
               
                 792 
                 Table_0792_GCB_1025_B.txt 
                 12,034,295 
                 Aug. 12, 2004 
               
               
                 793 
                 Table_0793_GCB_1026_A.txt 
                 11,998,844 
                 Aug. 12, 2004 
               
               
                 794 
                 Table_0794_GCB_1026_B.txt 
                 11,924,830 
                 Aug. 13, 2004 
               
               
                 795 
                 Table_0795_GCB_1037_A.txt 
                 12,102,751 
                 Aug. 13, 2004 
               
               
                 796 
                 Table_0796_GCB_1037_B.txt 
                 12,033,344 
                 Aug. 12, 2004 
               
               
                 797 
                 Table_0797_GCB_1039_A.txt 
                 12,138,545 
                 Aug. 13, 2004 
               
               
                 798 
                 Table_0798_GCB_1039_B.txt 
                 11,995,022 
                 Aug. 13, 2004 
               
               
                 799 
                 Table_0799_GCB_1049_A.txt 
                 11,910,885 
                 Aug. 13, 2004 
               
            
           
           
               
            
               
                 Disc 15 of 22 
               
            
           
           
               
               
               
               
            
               
                 800 
                 Table_0800_GCB_1049_B.txt 
                 11,900,529 
                 Aug. 12, 2004 
               
               
                 801 
                 Table_0801_GCB_1051_A.txt 
                 12,096,658 
                 Aug. 12, 2004 
               
               
                 802 
                 Table_0802_GCB_1051_B.txt 
                 11,899,594 
                 Aug. 12, 2004 
               
               
                 803 
                 Table_0803_GCB_1058_A.txt 
                 12,014,086 
                 Aug. 12, 2004 
               
               
                 804 
                 Table_0804_GCB_1058_B.txt 
                 11,833,626 
                 Aug. 13, 2004 
               
               
                 805 
                 Table_0805_GCB_1060_A.txt 
                 12,148,321 
                 Aug. 13, 2004 
               
               
                 806 
                 Table_0806_GCB_1060_B.txt 
                 11,922,074 
                 Aug. 12, 2004 
               
               
                 807 
                 Table_0807_GCB_1990_A.txt 
                 12,081,238 
                 Aug. 12, 2004 
               
               
                 808 
                 Table_0808_GCB_1990_B.txt 
                 11,844,167 
                 Aug. 13, 2004 
               
               
                 809 
                 Table_0809_GCB_1991_A.txt 
                 12,099,680 
                 Aug. 12, 2004 
               
               
                 810 
                 Table_0810_GCB_1991_B.txt 
                 11,928,351 
                 Aug. 12, 2004 
               
               
                 811 
                 Table_0811_GCB_2017_A.txt 
                 12,118,675 
                 Aug. 13, 2004 
               
               
                 812 
                 Table_0812_GCB_2017_B.txt 
                 11,975,326 
                 Aug. 13, 2004 
               
               
                 813 
                 Table_0813_GCB_2018_A.txt 
                 11,925,112 
                 Aug. 12, 2004 
               
               
                 814 
                 Table_0814_GCB_2018_B.txt 
                 11,835,888 
                 Aug. 13, 2004 
               
               
                 815 
                 Table_0815_GCB_2095_A.txt 
                 11,853,266 
                 Aug. 12, 2004 
               
               
                 816 
                 Table_0816_GCB_2095_B.txt 
                 11,623,773 
                 Aug. 12, 2004 
               
               
                 817 
                 Table_0817_GCB_880_A.txt 
                 12,152,952 
                 Aug. 13, 2004 
               
               
                 818 
                 Table_0818_GCB_860_B.txt 
                 12,010,773 
                 Aug. 13, 2004 
               
               
                 819 
                 Table_0819_GCB_871_A.txt 
                 12,244,981 
                 Aug. 13, 2004 
               
               
                 820 
                 Table_0820_GCB_871_B.txt 
                 12,006,799 
                 Aug. 12, 2004 
               
               
                 821 
                 Table_0821_GCB_874_A.txt 
                 12,105,710 
                 Aug. 12, 2004 
               
               
                 822 
                 Table_0822_GCB_874_B.txt 
                 11,844,703 
                 Aug. 13, 2004 
               
               
                 823 
                 Table_0823_GCB_995_A.txt 
                 12,155,927 
                 Aug. 12, 2004 
               
               
                 824 
                 Table_0824_GCB_995_B.txt 
                 11,924,018 
                 Aug. 13, 2004 
               
               
                 825 
                 Table_0825_LPC_2224_A.txt 
                 12,213,302 
                 Aug. 12, 2004 
               
               
                 826 
                 Table_0826_LPC_2224_B.txt 
                 12,044,437 
                 Aug. 13, 2004 
               
               
                 827 
                 Table_0827_LPC_2232_A.txt 
                 12,166,888 
                 Aug. 12, 2004 
               
               
                 828 
                 Table_0828_LPC_2232_B.txt 
                 12,125,903 
                 Aug. 12, 2004 
               
               
                 829 
                 Table_0829_LPC_2261_A.txt 
                 12,228,399 
                 Aug. 13, 2004 
               
               
                 830 
                 Table_0830_LPC_2261_B.txt 
                 12,102,498 
                 Aug. 12, 2604 
               
               
                 831 
                 Table_0831_LPC_2262_A.txt 
                 12,312,435 
                 Aug. 13, 2004 
               
               
                 832 
                 Table_0832_LPC_2262_B.txt 
                 12,152,420 
                 Aug. 12, 2004 
               
               
                 833 
                 Table_0833_LPC_2263_A.txt 
                 12,224,752 
                 Aug. 12, 2004 
               
               
                 834 
                 Table_0834_LPC_2263_B.txt 
                 12,026,718 
                 Aug. 12, 2004 
               
               
                 835 
                 Table_0835_LPC_2265_A.txt 
                 12,285,962 
                 Aug. 12, 2004 
               
               
                 836 
                 Table_0836_LPC_2265_B.txt 
                 12,154,010 
                 Aug. 12, 2004 
               
               
                 837 
                 Table_0837_Lymbl_2185_A.txt 
                 12,108,958 
                 Aug. 12, 2004 
               
               
                 838 
                 Table_0838_Lymbl_2185_B.txt 
                 11,820,956 
                 Aug. 12, 2004 
               
               
                 839 
                 Table_0839_Lymbl_2186_A.txt 
                 12,308,145 
                 Aug. 12, 2004 
               
               
                 840 
                 Table_0840_Lymbl_2186_B.txt 
                 11,977,289 
                 Aug. 12, 2004 
               
               
                 841 
                 Table_0841_Lymbl_2249_A.txt 
                 12,199,046 
                 Aug. 12, 2004 
               
               
                 842 
                 Table_0842_Lymbl_2249_B.txt 
                 12,100,855 
                 Aug. 12, 2004 
               
               
                 843 
                 Table_0843_MALT_gastric_2021_A.txt 
                 12,069,340 
                 Aug. 12, 2004 
               
               
                 844 
                 Table_0844_MALT_gastric_2021_B.txt 
                 11,713,090 
                 Aug. 12, 2004 
               
               
                 845 
                 Table_0845_MALT_gastric_2041_A.txt 
                 12,022,811 
                 Aug. 12, 2004 
               
               
                 846 
                 Table_0846_MALT_gastric_2041_B.txt 
                 11,764,218 
                 Aug. 12, 2004 
               
               
                 847 
                 Table_0847_MALT_gastric_2065_A.txt 
                 12,078,944 
                 Aug. 12, 2004 
               
               
                 848 
                 Table_0848_MALT_gastric_2065_B.txt 
                 11,791,876 
                 Aug. 12, 2004 
               
               
                 849 
                 Table_0849_MALT_gastric_2067_A.txt 
                 12,202,669 
                 Aug. 12, 2004 
               
               
                 850 
                 Table_0850_MALT_gastric_2067_B.txt 
                 11,926,251 
                 Aug. 12, 2004 
               
               
                 851 
                 Table_0851_MALT_gastric_2070_A.txt 
                 11,759,597 
                 Aug. 12, 2004 
               
               
                 852 
                 Table_0852_MALT_gastric_2070_B.txt 
                 11,923,213 
                 Aug. 12, 2004 
               
               
                 853 
                 Table_0853_MALT_gastric_2110_A.txt 
                 11,989,061 
                 Aug. 12, 2004 
               
               
                 854 
                 Table_0854_MALT_gastric_2110_B.txt 
                 11,861,974 
                 Aug. 12, 2004 
               
               
                 855 
                 Table_0855_MALT_gastric_2111_A.txt 
                 11,875,847 
                 Aug. 12, 2004 
               
               
                 856 
                 Table_0856_MALT_gastric_2111_B.txt 
                 11,771,686 
                 Aug. 12, 2004 
               
               
                 857 
                 Table_0857_MALT_gastric_2112_A.txt 
                 11,987,235 
                 Aug. 12, 2004 
               
               
                 858 
                 Table_0858_MALT_gastric_2112_B.txt 
                 11,789,775 
                 Aug. 12, 2004 
               
               
                 859 
                 Table_0859_MALT_gastric_2270_A.txt 
                 12,163,208 
                 Aug. 12, 2004 
               
               
                 860 
                 Table_0860_MALT_gastric_2270_B.txt 
                 11,933,606 
                 Aug. 12, 2004 
               
            
           
           
               
            
               
                 Disc 16 of 22 
               
            
           
           
               
               
               
               
            
               
                 861 
                 Table_0861_MALT_lung_2202_A.txt 
                 12,272,098 
                 Aug. 12, 2004 
               
               
                 862 
                 Table_0862_MALT_lung_2202_B.txt 
                 12,060,494 
                 Aug. 12, 2004 
               
               
                 863 
                 Table_0863_MALT_salivary_2243_A.txt 
                 12,192,735 
                 Aug. 12, 2004 
               
               
                 864 
                 Table_0864_MALT_salivary_2243_B.txt 
                 11,939,205 
                 Aug. 12, 2004 
               
               
                 865 
                 Table_0865_MALT_tonsil_2211_A.txt 
                 12,292,687 
                 Aug. 12, 2004 
               
               
                 866 
                 Table_0866_MALT_tonsil_2211_B.txt 
                 12,028,847 
                 Aug. 12, 2004 
               
               
                 867 
                 Table_0867_MALT_unk_2178_A.txt 
                 12,272,896 
                 Aug. 12, 2004 
               
               
                 868 
                 Table_0868_MALT_unk_2178_B.txt 
                 11,942,813 
                 Aug. 12, 2004 
               
               
                 869 
                 Table_0869_MALT_unk_2182_A.txt 
                 12,152,087 
                 Aug. 12, 2004 
               
               
                 870 
                 Table_0870_MALT_unk_2182_B.txt 
                 11,862,788 
                 Aug. 12, 2004 
               
               
                 871 
                 Table_0871_MALT_unk_2183_A.txt 
                 12,240,465 
                 Aug. 12, 2004 
               
               
                 872 
                 Table_0872_MALT_unk_2183_B.txt 
                 11,910,769 
                 Aug. 12, 2004 
               
               
                 873 
                 Taable_0873_MALT_unk_2184_A.txt 
                 12,131,543 
                 Aug. 12, 2004 
               
               
                 874 
                 Table_0874_MALT_unk_2184_A.txt 
                 11,790,493 
                 Aug. 12, 2004 
               
               
                 875 
                 Table_0875_MCL_1012_A.txt 
                 12,095,014 
                 Aug. 12, 2004 
               
               
                 876 
                 Table_0876_MCL_1012_B.txt 
                 12,009,170 
                 Aug. 12, 2004 
               
               
                 877 
                 Table_0877_MCL_885_A.txt 
                 12,252,079 
                 Aug. 13, 2004 
               
               
                 878 
                 Table_0878_MCL_885_B.txt 
                 12,003,985 
                 Aug. 13, 2004 
               
               
                 879 
                 Table_0879_MCL_918_A.txt 
                 12,067,434 
                 Aug. 12, 2004 
               
               
                 880 
                 Table_0880_MCL_918_B.txt 
                 11,913,221 
                 Aug. 13, 2004 
               
               
                 881 
                 Table_0881_MCL_924_A.txt 
                 12,132,102 
                 Aug. 13, 2004 
               
               
                 882 
                 Table_0882_MCL_924_B.txt 
                 11,963,278 
                 Aug. 12, 2004 
               
               
                 883 
                 Table_0883_MCL_925_A.txt 
                 12,192,477 
                 Aug. 13, 2004 
               
               
                 884 
                 Table_0884_MCL_925_B.txt 
                 11,969,040 
                 Aug. 13, 2004 
               
               
                 885 
                 Table_0885_MCL_926_A.txt 
                 12,235,529 
                 Aug. 12, 2004 
               
               
                 886 
                 Table_0886_MCL_926_B.txt 
                 12,047,299 
                 Aug. 13, 2004 
               
               
                 887 
                 Table_0887_MCL_936_A.txt 
                 12,241,467 
                 Aug. 13, 2004 
               
               
                 888 
                 Table_0888_MCL_936_B.txt 
                 12,045,327 
                 Aug. 13, 2004 
               
               
                 889 
                 Table_0889_MCL_939_A.txt 
                 12,202,107 
                 Aug. 13, 2004 
               
               
                 890 
                 Table_0890_MCL_939_B.txt 
                 11,958,874 
                 Aug. 12, 2004 
               
               
                 891 
                 Table_0891_MCL_953_A.txt 
                 11,892,010 
                 Aug. 12, 2004 
               
               
                 892 
                 Table_0892_MCL_953_B.txt 
                 11,760,154 
                 Aug. 13, 2004 
               
               
                 893 
                 Table_0893_MCL_956_A.txt 
                 12,251,157 
                 Aug. 13, 2004 
               
               
                 894 
                 Tabte_0894_MCL_956_B.txt 
                 12,111,836 
                 Aug. 12, 2004 
               
               
                 895 
                 Table_0895_MCL_964_A.txt 
                 12,275,186 
                 Aug. 13, 2004 
               
               
                 898 
                 Table_0896_MCL_964_B.txt 
                 12,133,152 
                 Aug. 12, 2004 
               
               
                 897 
                 Table_0897_MCL_966_A.txt 
                 12,259,135 
                 Aug. 12, 2004 
               
               
                 898 
                 Table_0898_MCL_966_B.txt 
                 12,024,326 
                 Aug. 13, 2004 
               
               
                 899 
                 Table_0899_MCL_968_A.txt 
                 12,155,882 
                 Aug. 13, 2004 
               
               
                 900 
                 Table_0900_MCL_968_B.txt 
                 11,994,843 
                 Aug. 13, 2004 
               
               
                 901 
                 Table_0901_MCL_970_A.txt 
                 12,088,529 
                 Aug. 13, 2004 
               
               
                 902 
                 Table_0902_MCL_970_B.txt 
                 11,954,394 
                 Aug. 13, 2004 
               
               
                 903 
                 Table_0903_MCL_1091_A.txt 
                 12,094,827 
                 Aug. 13, 2004 
               
               
                 904 
                 Table_0904_MCL_1091_B.txt 
                 11,874,993 
                 Aug. 13, 2004 
               
               
                 905 
                 Table_0905_MCL_1114_A.txt 
                 12,245,076 
                 Aug. 13, 2004 
               
               
                 906 
                 Table_0906_MCL_1114_B.txt 
                 12,198,851 
                 Aug. 13, 2004 
               
               
                 907 
                 Table_0907_MCL_1128_A.txt 
                 12,001,197 
                 Aug. 13, 2004 
               
               
                 908 
                 Table_0908_MCL_1128_B.txt 
                 11,988,339 
                 Aug. 12, 2004 
               
               
                 909 
                 Table_0909_MCL_1150_A.txt 
                 12,152,268 
                 Aug. 12, 2004 
               
               
                 910 
                 Table_0910_MCL_1150_B.txt 
                 11,985,382 
                 Aug. 13, 2004 
               
               
                 911 
                 Table_0911_MCL_1162_A.txt 
                 12,052,700 
                 Aug. 13, 2004 
               
               
                 912 
                 Table_0912_MCL_1162_B.txt 
                 11,813,424 
                 Aug. 13, 2004 
               
               
                 913 
                 Table_0913_MCL_1166_A.txt 
                 12,154,210 
                 Aug. 13, 2004 
               
               
                 914 
                 Table_0914_MCL_1166_B.txt 
                 11,978,362 
                 Aug. 13, 2004 
               
               
                 915 
                 Table_1915_MCL_1194_A.txt 
                 12,219,860 
                 Aug. 12, 2004 
               
               
                 916 
                 Table_0916_MCL_1194_B.txt 
                 11,956,615 
                 Aug. 12, 2004 
               
               
                 917 
                 Table_0917_Mult_Myeloma_H1112_100001_A.txt 
                 11,811,143 
                 Aug. 12, 2004 
               
               
                 918 
                 Table_0918_Mult_Myeloma_H1112_100001_B.txt 
                 1,607,110 
                 Aug. 12, 2004 
               
               
                 919 
                 Table_0919_Mult_Myeloma_HDLM2_100002_A.txt 
                 12,201,407 
                 Aug. 12, 2004 
               
               
                 920 
                 Table_0920_Mult_Myeloma_HDLM2_100002_B.txt 
                 12,064,162 
                 Aug. 12, 2004 
               
               
                 921 
                 Table_0921_Mult_Myeloma_JIM3_100003_A.txt 
                 12,018,803 
                 Aug. 12, 2004 
               
            
           
           
               
            
               
                 Disc 17 of 22 
               
            
           
           
               
               
               
               
            
               
                 922 
                 Table_0922_Mult_Myeloma_JJM3_100003_B.txt 
                 11,829,274 
                 Aug. 12, 2004 
               
               
                 923 
                 Table_0923_Mult_Myeloma_JJN3_100004_A.txt 
                 11,938,479 
                 Aug. 12, 2004 
               
               
                 924 
                 Table_0924_Mult_Myeloma_JJN3_100004_B.txt 
                 11,783,677 
                 Aug. 12, 2004 
               
               
                 925 
                 Table_0925_Mult_Myeloma_KMS11_100005_A.txt 
                 12,049,424 
                 Aug. 12, 2004 
               
               
                 926 
                 Table_0926_Mult_Myeloma_KMS11_100005_B.txt 
                 11,830,659 
                 Aug. 12, 2004 
               
               
                 927 
                 Table_0927_Mult_Myeloma_KMS12_100008_A.txt 
                 11,987,299 
                 Aug. 12, 2004 
               
               
                 928 
                 Table_0928_Mult_Myeloma_KMS12_100006_B.txt 
                 11,843,592 
                 Aug. 12, 2004 
               
               
                 929 
                 Table_0929_MuIt_Myeloma_LB84_100007_A.txt 
                 12,013,517 
                 Aug. 12, 2004 
               
               
                 930 
                 Table_0930_Mult_Myeloma_LB84_100007_B.txt 
                 11,779,980 
                 Aug. 12, 2004 
               
               
                 931 
                 Table_0931_Mult_Myeloma_LP1_100008_A.txt 
                 11,881,584 
                 Aug. 12, 2004 
               
               
                 932 
                 Table_0932_Mult_Myeloma_LP1_100008_B.txt 
                 11,697,789 
                 Aug. 12, 2004 
               
               
                 933 
                 Table_0933_Mult_Myeloma_U266_100009_A.txt 
                 11,911,589 
                 Aug. 12, 2004 
               
               
                 934 
                 Table_0934_Mult_Myeloma_U266_100009_B.txt 
                 11,746,068 
                 Aug. 12, 2004 
               
               
                 935 
                 Table_0935_NMZ_2231_A.txt 
                 12,102,948 
                 Aug. 12, 2004 
               
               
                 936 
                 Table_0936_NMZ_2231_B.txt 
                 11,924,657 
                 Aug. 13, 2004 
               
               
                 937 
                 Table_0937_NMZ_2242_A.txt 
                 12,155,728 
                 Aug. 13, 2004 
               
               
                 938 
                 Table_0938_NMZ_2242_B.txt 
                 11,868,614 
                 Aug. 12, 2004 
               
               
                 939 
                 Table_0939_NMZ_2254_A.txt 
                 12,192,220 
                 Aug. 12, 2004 
               
               
                 940 
                 Table_0940_NMZ_2254_B.txt 
                 11,993,870 
                 Aug. 13, 2004 
               
               
                 941 
                 Table_0941_PMBL_484_A.txt 
                 12,082,526 
                 Aug. 12, 2004 
               
               
                 942 
                 Table_0942_PMBL_484_B.txt 
                 11,815,878 
                 Aug. 12, 2004 
               
               
                 943 
                 Table_0943_PMBL_546_A.txt 
                 12,246,074 
                 Aug. 12, 2004 
               
               
                 944 
                 Table_0944_PMBL_546_B.txt 
                 12,018,016 
                 Aug. 13, 2004 
               
               
                 945 
                 Table_0945_PMBL_570_A.txt 
                 12,022,732 
                 Aug. 13, 2004 
               
               
                 946 
                 Table_0946_PMBL_570_B.txt 
                 11,987,920 
                 Aug. 12, 2004 
               
               
                 947 
                 Table_0947_PMBL_621_A.txt 
                 12,274,976 
                 Aug. 13, 2004 
               
               
                 948 
                 Table_0948_PMBL_621_B.txt 
                 11,990,316 
                 Aug. 12, 2004 
               
               
                 949 
                 Table_0949_PMBL_638_A.txt 
                 12,127,006 
                 Aug. 12, 2004 
               
               
                 950 
                 Table_0950_PMBL_638_B.txt 
                 11,914,175 
                 Aug. 13, 2004 
               
               
                 951 
                 Table_0951_PMBL_691_A.txt 
                 12,212,873 
                 Aug. 13, 2004 
               
               
                 952 
                 Table_0952_PMBL_691_B.txt 
                 11,914,318 
                 Aug. 12, 2004 
               
               
                 953 
                 Table_0953_PMBL_791_A.txt 
                 12,097,450 
                 Aug. 13, 2004 
               
               
                 954 
                 Table_0954_PMBL_791_B.txt 
                 11,992,010 
                 Aug. 13, 2004 
               
               
                 955 
                 Table_0955_PMBL_824_A.txt 
                 12,088,222 
                 Aug. 12, 2004 
               
               
                 956 
                 Table_0956_PMBL_824_B.txt 
                 11,955,158 
                 Aug. 12, 2004 
               
               
                 957 
                 Table_0957_PMBL_906_A.txt 
                 12,132,964 
                 Aug. 13, 2004 
               
               
                 958 
                 Table_0958_PMBL_906_B.txt 
                 11,995,056 
                 Aug. 12, 2004 
               
               
                 959 
                 Table_0959_PMBL_994_A.txt 
                 12,174,956 
                 Aug. 13, 2004 
               
               
                 960 
                 Table_0960_PMBL_994_B.txt 
                 11,819,415 
                 Aug. 12, 2004 
               
               
                 961 
                 Table_0961_PMBL_998_A.txt 
                 12,084,009 
                 Aug. 13, 2004 
               
               
                 962 
                 Table_0962_PMBL_998_B.txt 
                 11,893,733 
                 Aug. 12, 2004 
               
               
                 963 
                 Table_0963_PMBL_1006_A.txt 
                 12,028,424 
                 Aug. 10, 2004 
               
               
                 964 
                 Table_0964_PMBL_1006_B.txt 
                 11,935,369 
                 Aug. 10, 2004 
               
               
                 965 
                 Table_0965_PMBL_1024_A.txt 
                 11,957,270 
                 Aug. 10, 2004 
               
               
                 966 
                 Table_0966_PMBL_1024_B.txt 
                 11,764,809 
                 Aug. 10, 2004 
               
               
                 967 
                 Table_0967_PMBL_1048_A.txt 
                 11,897,468 
                 Aug. 10, 2004 
               
               
                 968 
                 Table_0968_PMBL_1048_B.txt 
                 11,883,251 
                 Aug. 10, 2004 
               
               
                 969 
                 Table_0969_PMBL_1053_A.txt 
                 11,875,959 
                 Aug. 10, 2004 
               
               
                 970 
                 Table_0970_PMBL_1053_B.txt 
                 11,710,774 
                 Aug. 10, 2004 
               
               
                 971 
                 Table_0971_PMBL_1920_A.txt 
                 12,226,172 
                 Aug. 10, 2004 
               
               
                 972 
                 Table_0972_PMBL_1920_B.txt 
                 12,193,948 
                 Aug. 10, 2004 
               
               
                 973 
                 Table_0973_PMBL_1921_A.txt 
                 12,143,375 
                 Aug. 10, 2004 
               
               
                 974 
                 Table_0974_PMBL_1921_B.txt 
                 11,908,102 
                 Aug. 10, 2004 
               
               
                 975 
                 Table_0975_PMBL_1923_A.txt 
                 12,198,159 
                 Aug. 10, 2004 
               
               
                 976 
                 Table_0976_PMBL_1923_B.txt 
                 11,946,971 
                 Aug. 10, 2004 
               
               
                 977 
                 Table_0977_PMBL_1924_A.txt 
                 12,122,855 
                 Aug. 10, 2004 
               
               
                 978 
                 Table_0978_PMBL_1924_B.txt 
                 11,890,275 
                 Aug. 10, 2004 
               
               
                 979 
                 Table_0979_PMBL_1935_A.txt 
                 12,068,019 
                 Aug. 10, 2004 
               
               
                 980 
                 Table_0980_PMBL_1935_B.txt 
                 11,985,509 
                 Aug. 10, 2004 
               
               
                 981 
                 Table_0981_PMBL_1941_A.txt 
                 12,119,223 
                 Aug. 10, 2004 
               
               
                 982 
                 Table_0982_PMBL_1941_B.txt 
                 11,930,039 
                 Aug. 10, 2004 
               
            
           
           
               
            
               
                 Disc 18 of 22 
               
            
           
           
               
               
               
               
            
               
                 983 
                 Table_0983_PMBL_1942_A.txt 
                 12,067,442 
                 Aug. 10, 2004 
               
               
                 984 
                 Table_0984_PMBL_1942_B.txt 
                 11,920,274 
                 Aug. 10, 2004 
               
               
                 985 
                 Table_0985_PMBL_1943_A.txt 
                 12,071,233 
                 Aug. 10, 2004 
               
               
                 986 
                 Table_0986_PMBL_1943_B.txt 
                 11,873,515 
                 Aug. 10, 2004 
               
               
                 987 
                 Table_0987_PMBL_1945_A.txt 
                 12,127,286 
                 Aug. 10, 2004 
               
               
                 988 
                 Table_0988_PMBL_1945_B.txt 
                 11,893,206 
                 Aug. 10, 2004 
               
               
                 989 
                 Table_0989_PMBL_1948_A.txt 
                 12,166,081 
                 Aug. 10, 2004 
               
               
                 990 
                 Table_0990_PMBL_1948_B.txt 
                 11,844,013 
                 Aug. 10, 2004 
               
               
                 991 
                 Table_0991_PMBL_1949_A.txt 
                 12,127,499 
                 Aug. 10, 2004 
               
               
                 992 
                 Table_0992_PMBL_1949_B.txt 
                 12,009,898 
                 Aug. 10, 2004 
               
               
                 993 
                 Table_0993_PMBL_1989_A.txt 
                 11,979,711 
                 Aug. 10, 2004 
               
               
                 994 
                 Table_0994_PMBL_1989_B.txt 
                 11,831,156 
                 Aug. 10, 2004 
               
               
                 995 
                 Table_0995_PMBL_1992_A.txt 
                 11,982,288 
                 Aug. 10, 2004 
               
               
                 996 
                 Table_0996_PMBL_1992_B.txt 
                 11,805,053 
                 Aug. 10, 2004 
               
               
                 997 
                 Table_0997_PMBL_1993_A.txt 
                 11,965,853 
                 Aug. 10, 2004 
               
               
                 998 
                 Table_0998_PMBL_1993_B.txt 
                 11,781,282 
                 Aug. 10, 2004 
               
               
                 999 
                 Table_0999_PMBL_2002_A.txt 
                 12,145,467 
                 Aug. 10, 2004 
               
               
                 1000 
                 Table_1000_PMBL_2002_B.txt 
                 11,908,468 
                 Aug. 10, 2004 
               
               
                 1001 
                 Table_1001_PMBL_2019_A.txt 
                 12,060,714 
                 Aug. 10, 2004 
               
               
                 1002 
                 Table_1002_PMBL_2019_B.txt 
                 11,835,919 
                 Aug. 10, 2004 
               
               
                 1003 
                 Table_1003_PMBL_2020_A.txt 
                 11,923,777 
                 Aug. 10, 2004 
               
               
                 1004 
                 Table_1004_PMBL_2020_B.txt 
                 11,763,296 
                 Aug. 10, 2004 
               
               
                 1005 
                 Table_1005_PMBL_2092_A.txt 
                 11,790,019 
                 Aug. 10, 2004 
               
               
                 1006 
                 Table_1006_PMBL_2092_B.txt 
                 11,681,328 
                 Aug. 10, 2004 
               
               
                 1007 
                 Table_1007_PTLD_1817_A.txt 
                 11,963,639 
                 Aug. 10, 2004 
               
               
                 1008 
                 Table_1008_PTLD_1817_B.txt 
                 11,841,407 
                 Aug. 10, 2004 
               
               
                 1009 
                 Table_1009_PTLD_1824_A.txt 
                 11,948,464 
                 Aug. 10, 2004 
               
               
                 1010 
                 Table_1010_PTLD_1824_B.txt 
                 11,908,800 
                 Aug. 10, 2004 
               
               
                 1011 
                 Table_1011_PTLD_1981_A.txt 
                 12,117,957 
                 Aug. 10, 2004 
               
               
                 1012 
                 Table_1012_PTLD_1981_B.txt 
                 11,889,503 
                 Aug. 10, 2004 
               
               
                 1013 
                 Table_1013_PTLD_1986_A.txt 
                 12,190,747 
                 Aug. 10, 2004 
               
               
                 1014 
                 Table_1014_PTLD_1986_B.txt 
                 11,999,062 
                 Aug. 10, 2004 
               
               
                 1015 
                 Table_1015_SLL_1151_A.txt 
                 12,137,203 
                 Aug. 10, 2004 
               
               
                 1016 
                 Table_1016_SLL_1151_B.txt 
                 12,068,815 
                 Aug. 10, 2004 
               
               
                 1017 
                 Table_1017_SLL_1153_A.txt 
                 12,167,324 
                 Aug. 10, 2004 
               
               
                 1018 
                 Table_1018_SLL_1153_B.txt 
                 11,973,110 
                 Aug. 10, 2004 
               
               
                 1019 
                 Table_1019_SLL_1155_A.txt 
                 12,014,085 
                 Aug. 10, 2004 
               
               
                 1020 
                 Table_1020_SLL_1155_B.txt 
                 11,972,994 
                 Aug. 10, 2004 
               
               
                 1021 
                 Table_1021_SLL_1156_A.txt 
                 12,049,347 
                 Aug. 10, 2004 
               
               
                 1022 
                 Table_1022_SLL_1156_B.txt 
                 12,067,063 
                 Aug. 10, 2004 
               
               
                 1023 
                 Table_1023_SLL_1158_A.txt 
                 12,133,241 
                 Aug. 13, 2004 
               
               
                 1024 
                 Table_1024_SLL_1158_B.txt 
                 11,956,872 
                 Aug. 13, 2004 
               
               
                 1025 
                 Table_1025_SLL_1213_A.txt 
                 12,143,857 
                 Aug. 13, 2004 
               
               
                 1026 
                 Table_1026_SLL_1213_B.txt 
                 12,011,763 
                 Aug. 13, 2004 
               
               
                 1027 
                 Table_1027_SLL_1214_A.txt 
                 12,045,032 
                 Aug. 13, 2004 
               
               
                 1028 
                 Table_1028_SLL_1214_B.txt 
                 12,031,831 
                 Aug. 13, 2004 
               
               
                 1029 
                 Table_1029_SLL_1216_A.txt 
                 11,833,813 
                 Aug. 13, 2004 
               
               
                 1030 
                 Table_1030_SLL_1216_B.txt 
                 11,772,139 
                 Aug. 13, 2004 
               
               
                 1031 
                 Table_1031_SLL_1217_A.txt 
                 12,094,981 
                 Aug. 12, 2004 
               
               
                 1032 
                 Table_1032_SLL_1217_B.txt 
                 11,937,188 
                 Aug. 12, 2004 
               
               
                 1033 
                 Table_1033_SLL_1218_A.txt 
                 11,940,236 
                 Aug. 13, 2004 
               
               
                 1034 
                 Table_1034_SLL_1218_B.txt 
                 11,959,292 
                 Aug. 13, 2004 
               
               
                 1035 
                 Table_1035_SLL_1220_A.txt 
                 12,120,053 
                 Aug. 13, 2004 
               
               
                 1036 
                 Table_1036_SLL_1220_B.txt 
                 12,048,618 
                 Aug. 13, 2004 
               
               
                 1037 
                 Table_1037_SLL_1229_A.txt 
                 12,163,710 
                 Aug. 13, 2004 
               
            
           
           
               
            
               
                 Disc 19 of 22 
               
            
           
           
               
               
               
               
            
               
                 1038 
                 Table_1038_SLL_1229_B.txt 
                 12,055,954 
                 Aug. 13, 2004 
               
               
                 1039 
                 Table_1039_SLL_1231_A.txt 
                 12,991,514 
                 Aug. 12, 2004 
               
               
                 1040 
                 Table_1040_SLL_1231_B.txt 
                 12,005,235 
                 Aug. 13, 2004 
               
               
                 1041 
                 Table_1041_SLL_1235_A.txt 
                 12,080,267 
                 Aug. 13, 2904 
               
               
                 1042 
                 Table_1042_SLL_1235_B.txt 
                 11,994,892 
                 Aug. 12, 2004 
               
               
                 1043 
                 Table_1043_SLL_1236_A.txt 
                 12,084,789 
                 Aug. 13, 2004 
               
               
                 1044 
                 Table_1044_SLL_1236_B.txt 
                 12,026,667 
                 Aug. 13, 2004 
               
               
                 1045 
                 Table_1045_SLL_1238_A.txt 
                 12,082,819 
                 Aug. 12, 2004 
               
               
                 1046 
                 Table_1046_SLL_1238_B.txt 
                 11,974,701 
                 Aug. 13, 2004 
               
               
                 1047 
                 Table_1047_SLL_1240_A.txt 
                 12,107,426 
                 Aug. 13, 2004 
               
               
                 1048 
                 Table_1048_SLL_1240_B.txt 
                 12,007,704 
                 Aug. 12, 2004 
               
               
                 1049 
                 Table_1049_SPLENIC_2061_A.txt 
                 12,008,092 
                 Aug. 12, 2004 
               
               
                 1050 
                 Table_1050_SPLENIC_2061_B.txt 
                 11,899,642 
                 Aug. 12, 2004 
               
               
                 1051 
                 Table_1051_SPLENIC_2074_A.txt 
                 11,955,622 
                 Aug. 12, 2004 
               
               
                 1052 
                 Table_1052_SPLENIC_2074_B.txt 
                 11,890,462 
                 Aug. 12, 2004 
               
               
                 1053 
                 Table_1053_SPLENIC_2075_A.txt 
                 11,810,049 
                 Aug. 12, 2004 
               
               
                 1954 
                 Table_1054_SPLENIC_2075_B.txt 
                 11,772,595 
                 Aug. 12, 2004 
               
               
                 1055 
                 Table_1055_SPLENIC_2077_A.txt 
                 12,051,083 
                 Aug. 12, 2004 
               
               
                 1056 
                 Table_1056_SPLENIC_2077_B.txt 
                 11,816,491 
                 Aug. 12, 2004 
               
               
                 1057 
                 Table_1057_SPLENIC_2079_A.txt 
                 12,028,337 
                 Aug. 13, 2004 
               
               
                 1058 
                 Table_1058_SPLENIC_2079_B.txt 
                 11,666,448 
                 Aug. 12, 2004 
               
               
                 1059 
                 Table_1059_SPLENIC_2104_A.txt 
                 11,964,762 
                 Aug. 12, 2004 
               
               
                 1060 
                 Table_1060_SPLENIC_2104_B.txt 
                 11,883,377 
                 Aug. 12, 2004 
               
               
                 1061 
                 Table_1061_SPLENIC_2105_A.txt 
                 12,027,922 
                 Aug. 13, 2004 
               
               
                 1062 
                 Table_1062_SPLENIC_2105_B.txt 
                 11,816,300 
                 Aug. 12, 2004 
               
               
                 1063 
                 Table_1063_SPLENIC_2106_A.txt 
                 11,927,458 
                 Aug. 12, 2004 
               
               
                 1064 
                 Table_1064_SPLENIC_2106_B.txt 
                 11,707,237 
                 Aug. 13, 2004 
               
               
                 1065 
                 Table_1065_SPLENIC_2256_A.txt 
                 12,134,849 
                 Aug. 12, 2004 
               
               
                 1066 
                 Table_1066_SPLENIC_2256_B.txt 
                 12,000,432 
                 Aug. 12 2004 
               
               
                 1067 
                 Table_1067_SPLENIC_2257_A.txt 
                 12,095,918 
                 Aug. 12, 2004 
               
               
                 1068 
                 Table_1088_SPLENIC_2257_B.txt 
                 11,860,498 
                 Aug. 12, 2004 
               
               
                 1069 
                 Table_1069_SPLENIC_2258_A.txt 
                 12,173,033 
                 Aug. 12, 2004 
               
               
                 1070 
                 Table_1070_SPLENIC_2258_B.txt 
                 12,097,740 
                 Aug. 13, 2004 
               
               
                 1071 
                 Table_1071_SPLENIC_2259_A.txt 
                 12,070,761 
                 Aug. 12, 2004 
               
               
                 1072 
                 Table_1072_SPLENIC_2259_B.txt 
                 11,905,682 
                 Aug. 12, 2004 
               
               
                 1073 
                 Table_1073_SPLENIC_2260_A.txt 
                 12,218,038 
                 Aug. 12, 2004 
               
               
                 1074 
                 Table_1074_SPLENIC_2260_B.txt 
                 11,987,269 
                 Aug. 13, 2004 
               
               
                 1075 
                 Table_1075_UC_DLBCL_306_A.txt 
                 12,197,523 
                 Aug. 12, 2004 
               
               
                 1076 
                 Table_1076_UC_DLBCL_306_B.txt 
                 12,022,523 
                 Aug. 13, 2004 
               
               
                 1077 
                 Table_1077_UC_DLBCL_310_A.txt 
                 12,200,397 
                 Aug. 12, 2004 
               
               
                 1078 
                 Table_1078_UC_DLBCL_310_B.txt 
                 12,031,998 
                 Aug. 12, 2004 
               
               
                 1079 
                 Table_1079_UC_DLBCL_449_A.txt 
                 12,190,478 
                 Aug. 12, 2004 
               
               
                 1080 
                 Table_1080_UC_DLBCL_449_B.txt 
                 11,975,216 
                 Aug. 12, 2004 
               
               
                 1081 
                 Table_1081_UC_DLBCL_452_A.txt 
                 12,131,303 
                 Aug. 12, 2004 
               
               
                 1082 
                 Table_1082_UC_DLBCL_452_B.txt 
                 11,894,8Z0 
                 Aug. 13, 2004 
               
               
                 1083 
                 Table_1083_UC_DLBCL_1001_A.txt 
                 12,196,485 
                 Aug. 12, 2004 
               
               
                 1084 
                 Table_1084_UC_DLBCL_1001_B.txt 
                 11,918,908 
                 Aug. 13, 2004 
               
               
                 1085 
                 Table_1085_UC_DLBCL_1004_A.txt 
                 12,085,125 
                 Aug. 12, 2004 
               
               
                 1086 
                 Table_1086_UC_DLBCL_1004_B.txt 
                 11,976,628 
                 Aug. 13, 2004 
               
               
                 1087 
                 Table_1087_UC_DLBCL_1007_A.txt 
                 12,008,629 
                 Aug. 13, 2004 
               
               
                 1088 
                 Table_1088_UC_DLBCL_1007_B.txt 
                 11,894,817 
                 Aug. 12, 2004 
               
               
                 1089 
                 Table_1089_UC_DLBCL_1018_A.txt 
                 11,978,212 
                 Aug. 12, 2004 
               
               
                 1090 
                 Table_1090_UC_DLBCL_1018_B.txt 
                 11,779,082 
                 Aug. 12, 2004 
               
               
                 1091 
                 Table_1091_UC_DLBCL_1041_A.txt 
                 12,075,817 
                 Aug. 12, 2004 
               
               
                 1092 
                 Table_1092_UC_DLBCL_1041_B.txt 
                 11,954,441 
                 Aug. 13, 2004 
               
               
                 1093 
                 Table_1093_UC_DLBCL_1054_A.txt 
                 12,072,956 
                 Aug. 13, 2004 
               
               
                 1094 
                 Table_1094_UC_DLBCL_1054_B.txt 
                 11,888,591 
                 Aug. 12, 2004 
               
               
                 1095 
                 Table_1095_UC_DLBCL_1946_A.txt 
                 12,146,234 
                 Aug. 12, 2004 
               
               
                 1096 
                 Table_1096_UC_DLBCL_1946_B.txt 
                 11,972,987 
                 Aug. 13, 2004 
               
               
                 1097 
                 Table_1097_UC_DLBCL_458_A.txt 
                 12,259,814 
                 Aug. 12, 2004 
               
               
                 1098 
                 Table_1098_UC_DLBCL_458_B.txt 
                 12,079,665 
                 Aug. 12, 2004 
               
            
           
           
               
            
               
                 Disc 20 of 22 
               
            
           
           
               
               
               
               
            
               
                 1099 
                 Table_1099_UC_DLBCL_460_A.txt 
                 12,291,473 
                 Aug. 12, 2004 
               
               
                 1100 
                 Table_1100_UC_DLBCL_460_B.txt 
                 12,152,157 
                 Aug. 12, 2004 
               
               
                 1101 
                 Table_1101_UC_DLBCL_491_A.txt 
                 12,1Z7,657 
                 Aug. 12, 2004 
               
               
                 1102 
                 Table_1102_UC_DLBCL_491_B.txt 
                 11,939,054 
                 Aug. 12, 2004 
               
               
                 1103 
                 Table_1103_UC_DLCBL_528_A.txt 
                 12,222,657 
                 Aug. 12, 2004 
               
               
                 1104 
                 Table_1104_UC_DLCBL_528_B.txt 
                 12,030,161 
                 Aug. 12, 2004 
               
               
                 1105 
                 Table_1105_UC_DLCBL_615_A.txt 
                 12,093,006 
                 Aug. 12, 2004 
               
               
                 1106 
                 Table_l106_UC_DLCBL_615_B.txt 
                 11,905,401 
                 Aug. 12, 2004 
               
               
                 1107 
                 Table_1107_UC_DLCBL_625_A.txt 
                 12,182,746 
                 Aug. 12, 2004 
               
               
                 1108 
                 Table_1108_UC_DLCBL_625_B.txt 
                 11,978,584 
                 Aug. 12, 2004 
               
               
                 1109 
                 Table_1109_UC_DLCBL_664_A.txt 
                 12,147,340 
                 Aug. 12, 2004 
               
               
                 1110 
                 Table_1110_UC_DLCBL_664_B.txt 
                 11,921,611 
                 Aug. 12, 2004 
               
               
                 1111 
                 Table_1111_UC_DLCBL_671_A.txt 
                 12,235,865 
                 Aug. 12, 2004 
               
               
                 1112 
                 Table_1112_UC_DLCBL_671_B.txt 
                 12,025,944 
                 Aug. 12, 2004 
               
               
                 1113 
                 Table_1113_UC_DLCBL_682_A.txt 
                 12,139,932 
                 Aug. 12, 2004 
               
               
                 1114 
                 Table_1114_UC_DLCBL_682_B.txt 
                 11,999,845 
                 Aug. 12, 2004 
               
               
                 1115 
                 Table_1115_UC_DLCBL_683_A.txt 
                 12,159,705 
                 Aug. 12, 2004 
               
               
                 1116 
                 Table_1116_UC_DLCBL_683_B.txt 
                 11,904,634 
                 Aug. 12, 2004 
               
               
                 1117 
                 Table_1117_UC_DLCBL_684_A.txt 
                 12,172,978 
                 Aug. 12, 2004 
               
               
                 1118 
                 Table_1118_UC_DLCBL_684_B.txt 
                 11,926,785 
                 Aug. 12, 2004 
               
               
                 1119 
                 Table_1119_UC_DLCBL_748_A.txt 
                 12,035,936 
                 Aug. 12, 2004 
               
               
                 1120 
                 Table_1120_UC_DLCBL_748_B.txt 
                 11,907,789 
                 Aug. 12, 2004 
               
               
                 1121 
                 Table_1707_UC_DLCBL_751_A.txt 
                 12,044,311 
                 Aug. 12, 2004 
               
               
                 1122 
                 Table_1708_UC_DLCBL_751_B.txt 
                 11,684,690 
                 Aug. 12, 2004 
               
               
                 1123 
                 Table_1709_UC_DLCBL_808_A.txt 
                 12,173,769 
                 Aug. 12, 2004 
               
               
                 1124 
                 Table_1710_UC_DLCBL_808_B.txt 
                 11,894,695 
                 Aug. 12, 2004 
               
               
                 1125 
                 Table_1711_UC_DLCBL_831_A.txt 
                 12,093,914 
                 Aug. 12, 2004 
               
               
                 1126 
                 Table_1712_UC_DLCBL_831_B.txt 
                 11,864,674 
                 Aug. 12, 2004 
               
               
                 1127 
                 Table_1713_UC_DLCBL_834_A.txt 
                 12,104,086 
                 Aug. 12, 2004 
               
               
                 1128 
                 Table_1714_UC_DLCBL_834_B.txt 
                 11,923,742 
                 Aug. 12, 2004 
               
               
                 1129 
                 Table_1715_UC_DLCBL_838_A.txt 
                 12,098,316 
                 Aug. 12, 2004 
               
               
                 1130 
                 Table_1716_UC_DLCBL_838_B.txt 
                 11,966,988 
                 Aug. 12, 2004 
               
               
                 1131 
                 Table_1717_UC_DLCBL_851_A.txt 
                 12,228,013 
                 Aug. 12, 2004 
               
               
                 1132 
                 Table_1718_UC_DLCBL_851_B.txt 
                 12,052,993 
                 Aug. 12, 2004 
               
               
                 1133 
                 Table_1719_UC_DLCBL_854_A.txt 
                 12,265,143 
                 Aug. 12, 2004 
               
               
                 1134 
                 Table_1720_UC_DLCBL_854_B.txt 
                 12,132,832 
                 Aug. 12, 2004 
               
               
                 1135 
                 Table_1721_UC_DLCBL_855_A.txt 
                 12,008,306 
                 Aug. 12, 2004 
               
               
                 1136 
                 Table_1722_UC_DLCBL_855_B.txt 
                 11,859,284 
                 Aug. 12, 2004 
               
               
                 1137 
                 Table_1723_UC_DLCBL_856_A.txt 
                 12,049,127 
                 Aug. 12, 2004 
               
               
                 1138 
                 Table_1138_UC_DLCBL_856_B.txt 
                 11,827,365 
                 Aug. 12, 2004 
               
               
                 1139 
                 Table_1139_ABC_1000_log_signal.txt 
                 719,801 
                 Aug. 5, 2004 
               
               
                 1140 
                 Table_1140_ABC_1002_log_signal.txt 
                 719,835 
                 Aug. 5, 2004 
               
               
                 1141 
                 Table_1141_ABC_1023_log_signal.txt 
                 719,881 
                 Aug. 5, 2004 
               
               
                 1142 
                 Table_1142_ABC_1027_log_signal.txt 
                 719,747 
                 Aug. 5, 2004 
               
               
                 1143 
                 Table_1143_ABC_1031_log_signal.txt 
                 719,600 
                 Aug. 5, 2004 
               
               
                 1144 
                 Table_1144_ABC_1034_log_signal.txt 
                 719,676 
                 Aug. 5, 2004 
               
               
                 1145 
                 Table_1145_ABC_1038_log_signal.txt 
                 719,775 
                 Aug. 5, 2004 
               
               
                 1146 
                 Table_1146_ABC_1043_log_signal.txt 
                 719,870 
                 Aug. 5, 2004 
               
               
                 1147 
                 Table_1147_ABC_1045_log_signal.txt 
                 719,737 
                 Aug. 5, 2004 
               
               
                 1148 
                 Table_1148_ABC_1055_log_signal.txt 
                 719,776 
                 Aug. 5, 2004 
               
               
                 1149 
                 Table_1149_ABC_1057_log_signal.txt 
                 719,889 
                 Aug. 5, 2004 
               
               
                 1150 
                 Table_1150_ABC_1059_log_signal.txt 
                 719,667 
                 Aug. 5, 2004 
               
               
                 1151 
                 Table_1151_ABC_1061_log_signal.txt 
                 719,846 
                 Aug. 5, 2004 
               
               
                 1152 
                 Table_1152_ABC_1946_log_signal.txt 
                 719,287 
                 Aug. 5, 2004 
               
               
                 1153 
                 Table_1153_ABC_1994_log_signal.txt 
                 719,569 
                 Aug. 5, 2004 
               
               
                 1154 
                 Table_1154_ABC_2001_log_signal.txt 
                 719,782 
                 Aug. 5, 2004 
               
               
                 1155 
                 Table_1155_ABC_304_log_signal.txt 
                 719,749 
                 Aug. 5, 2004 
               
               
                 1156 
                 Table_1156_ABC_305_log_signal.txt 
                 719,882 
                 Aug. 5, 2004 
               
               
                 1157 
                 Table_1157_ABC_309_log_signal.txt 
                 719,614 
                 Aug. 5, 2004 
               
               
                 1158 
                 Table_1158_ABC_413_log_signal.txt 
                 719,850 
                 Aug. 5, 2004 
               
               
                 1159 
                 Table_1159_ABC_428_log_signal.txt 
                 719,605 
                 Aug. 5, 2004 
               
               
                 1160 
                 Table_1160_ABC_432_log_signal.txt 
                 719,814 
                 Aug. 5, 2004 
               
               
                 1161 
                 Table_1161_ABC_446_log_signal.txt 
                 719,655 
                 Aug. 5, 2004 
               
               
                 1162 
                 Table_1162_ABC_462_log_signal.txt 
                 719,759 
                 Aug. 5, 2004 
               
               
                 1163 
                 Table_1163_ABC_477_log_signal.txt 
                 719,684 
                 Aug. 5, 2004 
               
               
                 1164 
                 Table_1164_ABC_481_log_signal.txt 
                 719,824 
                 Aug. 5, 2004 
               
               
                 1165 
                 Table_1165_ABC_482_log_signal.txt 
                 719,812 
                 Aug. 5, 2004 
               
               
                 1166 
                 Table_1166_ABC_538_log_signal.txt 
                 719,582 
                 Aug. 5, 2004 
               
               
                 1167 
                 Table_1167_ABC_539_log_signal.txt 
                 719,812 
                 Aug. 5, 2004 
               
               
                 1168 
                 Table_1168_ABC_544_log_signal.txt 
                 719,917 
                 Aug. 5, 2004 
               
               
                 1169 
                 Table_1169_ABC_547_log_signal.txt 
                 719,719 
                 Aug. 5, 2004 
               
               
                 1170 
                 Table_1170_ABC_577_log_signal.txt 
                 719,622 
                 Aug. 5, 2004 
               
               
                 1171 
                 Table_1171_ABC_616_log_signal.txt 
                 719,564 
                 Aug. 5, 2004 
               
               
                 1172 
                 Table_1172_ABC_626_log_signal.txt 
                 719,672 
                 Aug. 5, 2004 
               
               
                 1173 
                 Table_1173_ABC_633_log_signal.txt 
                 719,756 
                 Aug. 5, 2004 
               
               
                 1174 
                 Table_1174_ABC_642_log_signal.txt 
                 719,791 
                 Aug. 5, 2004 
               
               
                 1175 
                 Table_1175_ABC_644_log_signal.txt 
                 719,998 
                 Aug. 5, 2004 
               
               
                 1176 
                 Table_1176_ABC_645_log_signal.txt 
                 719,824 
                 Aug. 5, 2004 
               
               
                 1177 
                 Table_1177_ABC_646_log_signal.txt 
                 719,780 
                 Aug. 5, 2004 
               
               
                 1178 
                 Table_1178_ABC_651_log_signal.txt 
                 719,979 
                 Aug. 5, 2004 
               
               
                 1179 
                 Table_1179_ABC_652_log_signal.txt 
                 719,932 
                 Aug. 5, 2004 
               
               
                 1180 
                 Table_1180_ABC_660_log_signal.txt 
                 719,428 
                 Aug. 5, 2004 
               
               
                 1181 
                 Table_1181_ABC_663_log_signal.txt 
                 719,951 
                 Aug. 5, 2004 
               
               
                 1182 
                 Table_1182_ABC_668_log_signal.txt 
                 719,742 
                 Aug. 5, 2004 
               
               
                 1183 
                 Table_1183_ABC_676_log_signal.txt 
                 719,842 
                 Aug. 5, 2004 
               
               
                 1184 
                 Table_1184_ABC_678_log_signal.txt 
                 719,668 
                 Aug. 5, 2004 
               
               
                 1185 
                 Table_1185_ABC_687_log_signal.txt 
                 719,947 
                 Aug. 5, 2004 
               
               
                 1186 
                 Table_1186_ABC_689_log_signal.txt 
                 719,928 
                 Aug. 5, 2004 
               
               
                 1187 
                 Table_1187_ABC_692_log_signal.txt 
                 719,778 
                 Aug. 5, 2004 
               
               
                 1188 
                 Table_1188_ABC_694_log_signal.txt 
                 719,758 
                 Aug. 5, 2004 
               
               
                 1189 
                 Table_1189_ABC_700_log_signal.txt 
                 719,746 
                 Aug. 5, 2004 
               
               
                 1190 
                 Table_1190_ABC_702_log_signal.txt 
                 719,782 
                 Aug. 5, 2004 
               
               
                 1191 
                 Table_1191_ABC_704_log_signal.txt 
                 719,787 
                 Aug. 5, 2004 
               
               
                 1192 
                 Table_1192_ABC_709_log_signal.txt 
                 719,756 
                 Aug. 5, 2004 
               
               
                 1193 
                 Table_1193_ABC_712_log_signal.txt 
                 719,071 
                 Aug. 5, 2004 
               
               
                 1194 
                 Table_1194_ABC_714_log_signal.txt 
                 719,901 
                 Aug. 5, 2004 
               
               
                 1195 
                 Table_1195_ABC_717_log_signal.txt 
                 719,580 
                 Aug. 5, 2004 
               
               
                 1196 
                 Table_1196_ABC_725_log_signal.txt 
                 719,602 
                 Aug. 5, 2004 
               
               
                 1197 
                 Table_1197_ABC_726_log_signal.txt 
                 719,595 
                 Aug. 5, 2004 
               
               
                 1198 
                 Table_1198_ABC_730_log_signal.txt 
                 719,857 
                 Aug. 5, 2004 
               
               
                 1199 
                 Table_1199_ABC_753_log_signal.txt 
                 719,754 
                 Aug. 5, 2004 
               
               
                 1200 
                 Table_1200_ABC_756_log_signal.txt 
                 719,818 
                 Aug. 5, 2004 
               
               
                 1201 
                 Table_1201_ABC_771_log_signal.txt 
                 719,890 
                 Aug. 5, 2004 
               
               
                 1202 
                 Table_1202_ABC_779_log_signal.txt 
                 719,647 
                 Aug. 5, 2004 
               
               
                 1203 
                 Table_1203_ABC_789_log_signal.txt 
                 719,947 
                 Aug. 5, 2004 
               
               
                 1204 
                 Table_1204_ABC_800_log_signal.txt 
                 719,536 
                 Aug. 5, 2004 
               
               
                 1205 
                 Table_1205_ABC_807_log_signal.txt 
                 719,798 
                 Aug. 5, 2004 
               
               
                 1206 
                 Table_1206_ABC_809_log_signal.txt 
                 719,863 
                 Aug. 5, 2004 
               
               
                 1207 
                 Table_1207_ABC_816_log_signal.txt 
                 719,339 
                 Aug. 5, 2004 
               
               
                 1208 
                 Table_1208_ABC_820_log_signal.txt 
                 719,562 
                 Aug. 5, 2004 
               
               
                 1209 
                 Table_1209_ABC_823_log_signal.txt 
                 719,555 
                 Aug. 5, 2004 
               
               
                 1210 
                 Table_1210_ABC_835_log_signal.txt 
                 719,584 
                 Aug. 5, 2004 
               
               
                 1211 
                 Table_1211_ABC_839_log_signal.txt 
                 719,866 
                 Aug. 5, 2004 
               
               
                 1212 
                 Table_1212_ABC_841_log_signal.txt 
                 719,900 
                 Aug. 5, 2004 
               
               
                 1213 
                 Table_1213_ABC_858_log_signal.txt 
                 719,601 
                 Aug. 5, 2004 
               
               
                 1214 
                 Table_1214_ABC_872_log_signal.txt 
                 719,762 
                 Aug. 5, 2004 
               
               
                 1215 
                 Table_1215_ABC_875_log_signal.txt 
                 719,888 
                 Aug. 5, 2004 
               
               
                 1216 
                 Table_1216_ABC_912_log_signal.txt 
                 719,587 
                 Aug. 5, 2004 
               
               
                 1217 
                 Table_1217_ABC_996_log_signal.txt 
                 719,844 
                 Aug. 5, 2004 
               
               
                 1218 
                 Table_1218_BL_2032_log_signal.txt 
                 719,439 
                 Aug. 5, 2004 
               
               
                 1219 
                 Table_1219_BL_2033_log_signal.txt 
                 719,466 
                 Aug. 5, 2004 
               
               
                 1220 
                 Table_1220_BL_2035_log_signal.txt 
                 719,468 
                 Aug. 5, 2004 
               
               
                 1221 
                 Table_1221_BL_2036_log_signal.txt 
                 719,517 
                 Aug. 5, 2004 
               
               
                 1222 
                 Table_1222_BL_2037_log_signal.txt 
                 720,059 
                 Aug. 5, 2004 
               
               
                 1223 
                 Table_1223_BL_2038_log_signal.txt 
                 719,518 
                 Aug. 5, 2004 
               
               
                 1224 
                 Table_1224_BL_2082_log_signal.txt 
                 719,809 
                 Aug. 5, 2004 
               
               
                 1225 
                 Table_1225_BL_2083_log_signal.txt 
                 719,328 
                 Aug. 5, 2004 
               
               
                 1226 
                 Table_1226_BL_2086_log_signal.txt 
                 719,338 
                 Aug. 5, 2004 
               
               
                 1227 
                 Table_1227_BL_2088_log_signal.txt 
                 719,656 
                 Aug. 5, 2004 
               
               
                 1228 
                 Table_1228_BL_2090_log_signal.txt 
                 719,526 
                 Aug. 5, 2004 
               
               
                 1229 
                 Table_1229_BL_2091_log_signal.txt 
                 719,721 
                 Aug. 5, 2004 
               
               
                 1230 
                 Table_1230_BL_2097_log_signal.txt 
                 719,754 
                 Aug. 5, 2004 
               
               
                 1231 
                 Table_1231_BL_2099_log_signal.txt 
                 719,574 
                 Aug. 5, 2004 
               
               
                 1232 
                 Table_1232_BL_2100_log_signal.txt 
                 719,808 
                 Aug. 5, 2004 
               
               
                 1233 
                 Table_1233_BL_2101_log_signal.txt 
                 719,733 
                 Aug. 5, 2004 
               
               
                 1234 
                 Table_1234_BL_2103_log_signal.txt 
                 719,692 
                 Aug. 5, 2004 
               
               
                 1235 
                 Table_1235_BL_2125_log_signal.txt 
                 719,778 
                 Aug. 5, 2004 
               
               
                 1236 
                 Table_1236_BL_2126_log_signal.txt 
                 719,298 
                 Aug. 5, 2004 
               
               
                 1237 
                 Table_1237_BL_2127_log_signal.txt 
                 719,313 
                 Aug. 5, 2004 
               
               
                 1238 
                 Table_1238_BL_2128_log_signal.txt 
                 719,339 
                 Aug. 5, 2004 
               
               
                 1239 
                 Table_1239_BL_2129_log_signal.txt 
                 719,494 
                 Aug. 5, 2004 
               
               
                 1240 
                 Table_1240_BL_2267_log_signal.txt 
                 719,913 
                 Aug. 5, 2004 
               
               
                 1241 
                 Table_1241_BL_2268_log_signal.txt 
                 719,897 
                 Aug. 5, 2004 
               
               
                 1242 
                 Table_1242_BL_2269_log_signal.txt 
                 719,982 
                 Aug. 5, 2004 
               
               
                 1243 
                 Table_1243_BL_2271_log_signal.txt 
                 719,810 
                 Aug. 5, 2004 
               
               
                 1244 
                 Table_1244_CDnegMCL_1013_log_signal.txt 
                 719,496 
                 Aug. 5, 2004 
               
               
                 1245 
                 Table_1245_CDnegMCL_1116_log_signal.txt 
                 719,808 
                 Aug. 5, 2004 
               
               
                 1246 
                 Table_1246_CDnegMCL_1125_log_signal.txt 
                 719,557 
                 Aug. 5, 2004 
               
               
                 1247 
                 Table_1247_CDnegMCL_1265_log_signal.txt 
                 719,740 
                 Aug. 5, 2004 
               
               
                 1248 
                 Table_1248_CDnegMCL_2198_log_signal.txt 
                 720,028 
                 Aug. 5, 2004 
               
               
                 1249 
                 Table_1249_CDnegMCL_2272_log_signal.txt 
                 719,923 
                 Aug. 5, 2004 
               
               
                 1250 
                 Table_1250_CDnegMCL_930_log_signal.txt 
                 719,949 
                 Aug. 5, 2004 
               
               
                 1251 
                 Table_1251_CDnegMCL_950_log_signal.txt 
                 719,891 
                 Aug. 5, 2004 
               
               
                 1252 
                 Table_1252_CDnegMCL_985_log_signal.txt 
                 719,797 
                 Aug. 5, 2004 
               
               
                 1253 
                 Table_1253_CDnegMCL_991_log_signal.txt 
                 719,686 
                 Aug. 5, 2004 
               
               
                 1254 
                 Table_1254_FH_2043_log_signal.txt 
                 719,919 
                 Aug. 5, 2004 
               
               
                 1255 
                 Table_1255_FH_2045_log_signal.txt 
                 719,763 
                 Aug. 5, 2004 
               
               
                 1256 
                 Table_1256_FH_2047_log_signal.txt 
                 719,878 
                 Aug. 5, 2004 
               
               
                 1257 
                 Table_1257_FH_2120_log_signal.txt 
                 719,940 
                 Aug. 5, 2004 
               
               
                 1258 
                 Table_1258_FH_2123_log_signal.txt 
                 719,708 
                 Aug. 5, 2004 
               
               
                 1259 
                 Table_1259_FH_2124_log_signal.txt 
                 719,815 
                 Aug. 5, 2004 
               
               
                 1260 
                 Table_1260_FH_2138_log_signal.txt 
                 719,598 
                 Aug. 5, 2004 
               
               
                 1261 
                 Table_1261_FH_2139_log_signal.txt 
                 719,714 
                 Aug. 5, 2004 
               
               
                 1262 
                 Table_1262_FH_2140_log_signal.txt 
                 719,841 
                 Aug. 5, 2004 
               
               
                 1263 
                 Table_1263_FH_2141_log_signal.txt 
                 719,943 
                 Aug. 5, 2004 
               
               
                 1264 
                 Table_1264_FH_2142_log_signal.txt 
                 720,060 
                 Aug. 5, 2004 
               
               
                 1265 
                 Table_1265_FH_2143_log_signal.txt 
                 719,848 
                 Aug. 5, 2004 
               
               
                 1266 
                 Table_1266_FH_2159_log_signal.txt 
                 719,736 
                 Aug. 5, 2004 
               
               
                 1267 
                 Table_1267_FH_2160_log_signal.txt 
                 719,593 
                 Aug. 5, 2004 
               
               
                 1268 
                 Table_1268_FH_2161_log_signal.txt 
                 719,835 
                 Aug. 5, 2004 
               
               
                 1269 
                 Table_1269_FH_2162_log_signal.txt 
                 719,992 
                 Aug. 5, 2004 
               
               
                 1270 
                 Table_1270_FH_2164_log_signal.txt 
                 719,854 
                 Aug. 5, 2004 
               
               
                 1271 
                 Table_1271_FH_2167_log_signal.txt 
                 719,840 
                 Aug. 5, 2004 
               
               
                 1272 
                 Table_1272_FL_1073_log_signal.txt 
                 720,209 
                 Aug. 5, 2004 
               
               
                 1273 
                 Table_1273_FL_1074_log_signal.txt 
                 719,873 
                 Aug. 5, 2004 
               
               
                 1274 
                 Table_1274_FL_1075_log_signal.txt 
                 719,955 
                 Aug. 5, 2004 
               
               
                 1275 
                 Table_1275_FL_1076_log_signal.txt 
                 719,619 
                 Aug. 5, 2004 
               
               
                 1276 
                 Table_1276_FL_1077_log_signal.txt 
                 720,121 
                 Aug. 5, 2004 
               
               
                 1277 
                 Table_1277_FL_1078_log_signal.txt 
                 719,889 
                 Aug. 5, 2004 
               
               
                 1278 
                 Table_1278_FL_1080_log_signal.txt 
                 719,874 
                 Aug. 5, 2004 
               
               
                 1279 
                 Table_1279_FL_1081_log_signal.txt 
                 720,141 
                 Aug. 5, 2004 
               
               
                 1280 
                 Table_1280_FL_1083_log_signal.txt 
                 719,878 
                 Aug. 5, 2004 
               
               
                 1281 
                 Table_1281_FL_1085_log_signal.txt 
                 719,880 
                 Aug. 5, 2004 
               
               
                 1282 
                 Table_1282_FL_1088_log_signal.txt 
                 720,121 
                 Aug. 5, 2004 
               
               
                 1283 
                 Table_1283_FL_1087_log_signal.txt 
                 719,871 
                 Aug. 5, 2004 
               
               
                 1284 
                 Table_1284_FL_1088_log_signal.txt 
                 720,091 
                 Aug. 5, 2004 
               
               
                 1285 
                 Table_1285_FL_1089_log_signal.txt 
                 719,828 
                 Aug. 5, 2004 
               
               
                 1286 
                 Table_1286_FL_1090_log_signal.txt 
                 719,732 
                 Aug. 5, 2004 
               
               
                 1287 
                 Table_1287_FL_1097_log_signal.txt 
                 720,055 
                 Aug. 5, 2004 
               
               
                 1288 
                 Table_1288_FL_1098_log_signal.txt 
                 719,840 
                 Aug. 5, 2004 
               
               
                 1289 
                 Table_1289_FL_1099_log_signal.txt 
                 719,977 
                 Aug. 5, 2004 
               
               
                 1290 
                 Table_1290_FL_1102_log_signal.txt 
                 719,965 
                 Aug. 5, 2004 
               
               
                 1291 
                 Table_1291_FL_1104_log_signal.txt 
                 719,937 
                 Aug. 5, 2004 
               
               
                 1292 
                 Table_1292_FL_1106_log_signal.txt 
                 720,129 
                 Aug. 5, 2004 
               
               
                 1293 
                 Table_1293_FL_1107_log_signal.txt 
                 719,953 
                 Aug. 5, 2004 
               
               
                 1294 
                 Table_1294_FL_1183_log_signal.txt 
                 719,964 
                 Aug. 5, 2004 
               
               
                 1295 
                 Table_1295_FL_1184_log_signal.txt 
                 720,112 
                 Aug. 5, 2004 
               
               
                 1296 
                 Table_1296_FL_1185_log_signal.txt 
                 719,953 
                 Aug. 5, 2004 
               
               
                 1297 
                 Table_1297_FL_1186_log_signal.txt 
                 720,207 
                 Aug. 5, 2004 
               
               
                 1298 
                 Table_1298_FL_1416_log_signal.txt 
                 720,101 
                 Aug. 5, 2004 
               
               
                 1299 
                 Table_1299_FL_1417_log_signal.txt 
                 719,952 
                 Aug. 5, 2004 
               
               
                 1300 
                 Table_1300_FL_1418_log_signal.txt 
                 719,997 
                 Aug. 5, 2004 
               
               
                 1301 
                 Table_1301_FL_1419_log_signal.txt 
                 720,048 
                 Aug. 5, 2004 
               
               
                 1302 
                 Table_1302_FL_1422_log_signal.txt 
                 720,019 
                 Aug. 5, 2004 
               
               
                 1303 
                 Table_1303_FL_1425_log_signal.txt 
                 719,916 
                 Aug. 5, 2004 
               
               
                 1304 
                 Table_1304_FL_1426_log_signal.txt 
                 719,932 
                 Aug. 5, 2004 
               
               
                 1305 
                 Table_1305_FL_1427_log_signal.txt 
                 719,845 
                 Aug. 5, 2004 
               
               
                 1306 
                 Table_1306_FL_1428_log_signal.txt 
                 720,012 
                 Aug. 5, 2004 
               
               
                 1307 
                 Table_1307_FL_1429_log_signal.txt 
                 719,987 
                 Aug. 5, 2004 
               
               
                 1308 
                 Table_1308_FL_1432_log_signal.txt 
                 719,795 
                 Aug. 5, 2004 
               
               
                 1309 
                 Table_1309_FL_1436_log_signal.txt 
                 720,028 
                 Aug. 5, 2004 
               
               
                 1310 
                 Table_1310_FL_1440_log_signal.txt 
                 720,006 
                 Aug. 5, 2004 
               
               
                 1311 
                 Table_1311_FL_1445_log_signal.txt 
                 719,751 
                 Aug. 5, 2004 
               
               
                 1312 
                 Table_1312_FL_1450_log_signal.txt 
                 719,861 
                 Aug. 5, 2004 
               
               
                 1313 
                 Table_1313_FL_1472_log_signal.txt 
                 719,814 
                 Aug. 5, 2004 
               
               
                 1314 
                 Table_1314_FL_1473_log_signal.txt 
                 720,151 
                 Aug. 5, 2004 
               
               
                 1315 
                 Table_1315_FL_1474_log_signal.txt 
                 720,027 
                 Aug. 5, 2004 
               
               
                 1316 
                 Table_1316_FL_1476_log_signal.txt 
                 720,008 
                 Aug. 5, 2004 
               
               
                 1317 
                 Table_1317_FL_1477_log_signal.txt 
                 719,820 
                 Aug. 5, 2004 
               
               
                 1318 
                 Table_1318_FL_1478_log_signal.txt 
                 719,706 
                 Aug. 5, 2004 
               
               
                 1319 
                 Table_1319_FL_1479_log_signal.txt 
                 719,857 
                 Aug. 5, 2004 
               
               
                 1320 
                 Table_1320_FL_1480_log_signal.txt 
                 719,713 
                 Aug. 5, 2004 
               
               
                 1321 
                 Table_1321_FL_1579_log_signal.txt 
                 719,886 
                 Aug. 5, 2004 
               
               
                 1322 
                 Table_1322_FL_1580_log_signal.txt 
                 720,037 
                 Aug. 5, 2004 
               
               
                 1323 
                 Table_1323_FL_1581_log_signal.txt 
                 719,898 
                 Aug. 5, 2004 
               
               
                 1324 
                 Table_1324_FL_1582_log_signal.txt 
                 720,070 
                 Aug. 5, 2004 
               
               
                 1325 
                 Table_1325_FL_1583_log_signal.txt 
                 719,968 
                 Aug. 5, 2004 
               
               
                 1325 
                 Table_1326_FL_1584_log_signal.txt 
                 719,970 
                 Aug. 5, 2004 
               
               
                 1327 
                 Table_1327_FL_1585_log_signal.txt 
                 720,077 
                 Aug. 5, 2004 
               
               
                 1328 
                 Table_1328_FL_1586_log_signal.txt 
                 719,908 
                 Aug. 5, 2004 
               
               
                 1329 
                 Table_1329_FL_1588_log_signal.txt 
                 719,859 
                 Aug. 5, 2004 
               
               
                 1330 
                 Table_1330_FL_1589_log_signal.txt 
                 720,122 
                 Aug. 5, 2004 
               
               
                 1331 
                 Table_1331_FL_1591_log_signal.txt 
                 719,928 
                 Aug. 5, 2004 
               
               
                 1332 
                 Table_1332_FL_1594_log_signal.txt 
                 719,773 
                 Aug. 5, 2004 
               
               
                 1333 
                 Table_1333_FL_1595_log_signal.txt 
                 720,045 
                 Aug. 5, 2004 
               
               
                 1334 
                 Table_1334_FL_1598_log_signal.txt 
                 720,003 
                 Aug. 5, 2004 
               
               
                 1335 
                 Table_1335_FL_1599_log_signal.txt 
                 720,156 
                 Aug. 5, 2004 
               
               
                 1336 
                 Table_1336_FL_1603_log_signal.txt 
                 720,165 
                 Aug. 5, 2004 
               
               
                 1337 
                 Table_1337_FL_1604_log_signal.txt 
                 719,845 
                 Aug. 5, 2004 
               
               
                 1338 
                 Table_1338_FL_1606_log_signal.txt 
                 720,024 
                 Aug. 5, 2004 
               
               
                 1339 
                 Table_1339_FL_1607_log_signal.txt 
                 719,923 
                 Aug. 5, 2004 
               
               
                 1340 
                 Table_1340_FL_1608_log_signal.txt 
                 719,907 
                 Aug. 5, 2004 
               
               
                 1341 
                 Table_1341_FL_1610_log_signal.txt 
                 719,954 
                 Aug. 5, 2004 
               
               
                 1342 
                 Table_1342_FL_1611_log_signal.txt 
                 719,961 
                 Aug. 5, 2004 
               
               
                 1343 
                 Table_1343_FL_1616_log_signal.txt 
                 719,081 
                 Aug. 5, 2004 
               
               
                 1344 
                 Table_1344_FL_1617_log_signal.txt 
                 719,893 
                 Aug. 5, 2004 
               
               
                 1345 
                 Table_1345_FL_1619_log_signal.txt 
                 719,886 
                 Aug. 5, 2004 
               
               
                 1346 
                 Table_1346_FL_1620_log_signal.txt 
                 719,913 
                 Aug. 5, 2004 
               
               
                 1347 
                 Table_1347_FL_1622_log_signal.txt 
                 719,925 
                 Aug. 5, 2004 
               
               
                 1348 
                 Table_1348_FL_1623_log_signal.txt 
                 720,149 
                 Aug. 5, 2004 
               
               
                 1349 
                 Table_1349_FL_1624_log_signal.txt 
                 719,971 
                 Aug. 5, 2004 
               
               
                 1350 
                 Table_1350_FL_1625_log_signal.txt 
                 719,688 
                 Aug. 5, 2004 
               
               
                 1351 
                 Table_1351_FL_1626_log_signal.txt 
                 719,891 
                 Aug. 5, 2004 
               
               
                 1352 
                 Table_1352_FL_1627_log_signal.txt 
                 719,949 
                 Aug. 5, 2004 
               
               
                 1353 
                 Table_1353_FL_1628_log_signal.txt 
                 719,751 
                 Aug. 5, 2004 
               
               
                 1354 
                 Table_1354_FL_1637_log_signal.txt 
                 719,870 
                 Aug. 5, 2004 
               
               
                 1355 
                 Table_1355_FL_1638_log_signal.txt 
                 720,010 
                 Aug. 5, 2004 
               
               
                 1356 
                 Table_1356_FL_1639_log_signal.txt 
                 719,825 
                 Aug. 5, 2004 
               
               
                 1357 
                 Table_1357_FL_1643_log_signal.txt 
                 719,945 
                 Aug. 5, 2004 
               
               
                 1358 
                 Table_1358_FL_1644_log_signal.txt 
                 719,707 
                 Aug. 5, 2004 
               
               
                 1359 
                 Table_1359_FL_1645_log_signal.txt 
                 719,953 
                 Aug. 5, 2004 
               
               
                 1360 
                 Table_1360_FL_1646_log_signal.txt 
                 719,942 
                 Aug. 5, 2004 
               
               
                 1361 
                 Table_1361_FL_1647_log_signal.txt 
                 719,782 
                 Aug. 5, 2004 
               
               
                 1362 
                 Table_1362_FL_1648_log_signal.txt 
                 719,810 
                 Aug. 5, 2004 
               
               
                 1363 
                 Table_1363_FL_1652_log_signal.txt 
                 719,812 
                 Aug. 5, 2004 
               
               
                 1364 
                 Table_1364_FL_1654_log_signal.txt 
                 719,608 
                 Aug. 5, 2004 
               
               
                 1365 
                 Table_1365_FL_1655_log_signal.txt 
                 719,993 
                 Aug. 5, 2004 
               
               
                 1366 
                 Table_1366_FL_1656_log_signal.txt 
                 710,658 
                 Aug. 5, 2004 
               
               
                 1367 
                 Table_1367_FL_1657_log_signal.txt 
                 719,908 
                 Aug. 5, 2004 
               
               
                 1368 
                 Table_1368_FL_1660_log_signal.txt 
                 720,041 
                 Aug. 5, 2004 
               
               
                 1369 
                 Table_1369_FL_1661_log_signal.txt 
                 720,024 
                 Aug. 5, 2004 
               
               
                 1370 
                 Table_1370_FL_1662_log_signal.txt 
                 719,835 
                 Aug. 5, 2004 
               
               
                 1371 
                 Table_1371_FL_1664_log_signal.txt 
                 719,887 
                 Aug. 5, 2004 
               
               
                 1372 
                 Table_1372_FL_1669_log_signal.txt 
                 719,806 
                 Aug. 5, 2004 
               
               
                 1373 
                 Table_1373_FL_1670_log_signal.txt 
                 719,796 
                 Aug. 5, 2004 
               
               
                 1374 
                 Table_1374_FL_1675_log_signal.txt 
                 719,960 
                 Aug. 5, 2004 
               
               
                 1375 
                 Table_1375_FL_1681_log_signal.txt 
                 720,066 
                 Aug. 5, 2004 
               
               
                 1376 
                 Table_1376_FL_1683_log_signal.txt 
                 719,956 
                 Aug. 5, 2004 
               
               
                 1377 
                 Table_1377_FL_1684_log_signal.txt 
                 719,691 
                 Aug. 5, 2004 
               
               
                 1378 
                 Table_1378_FL_1716_log_signal.txt 
                 719,855 
                 Aug. 5, 2004 
               
               
                 1379 
                 Table_1379_FL_1717_log_signal.txt 
                 719,963 
                 Aug. 5, 2004 
               
               
                 1380 
                 Table_1380_FL_1718_log_signal.txt 
                 720,047 
                 Aug. 5, 2004 
               
               
                 1381 
                 Table_1381_FL_1719_log_signal.txt 
                 719,885 
                 Aug. 5, 2004 
               
               
                 1382 
                 Table_1382_FL_1720_log_signal.txt 
                 719,792 
                 Aug. 5, 2004 
               
               
                 1383 
                 Table_1383_FL_1729_log_signal.txt 
                 720,000 
                 Aug. 5, 2004 
               
               
                 1384 
                 Table_1384_FL_1732_log_signal.txt 
                 719,633 
                 Aug. 5, 2004 
               
               
                 1385 
                 Table_1385_FL_l73S_log_signal.txt 
                 719,887 
                 Aug. 5, 2004 
               
               
                 1386 
                 Table_1386_FL_1761_log_signal.txt 
                 719,866 
                 Aug. 5, 2004 
               
               
                 1387 
                 Table_1387_FL_1764_log_signal.txt 
                 720,078 
                 Aug. 5, 2004 
               
               
                 1388 
                 Table_1388_FL_1768_log_signal.txt 
                 720,029 
                 Aug. 5, 2004 
               
               
                 1389 
                 Table_1389_FL_1771_log_signal.txt 
                 719,929 
                 Aug. 5, 2004 
               
               
                 1390 
                 Table_1390_FL_1772_log_signal.txt 
                 719,921 
                 Aug, 5, 2004 
               
               
                 1391 
                 Table_1391_FL_1788_log_signal.txt 
                 719,801 
                 Aug. 5, 2004 
               
               
                 1392 
                 Table_1392_FL_1790_log_signal.txt 
                 720,131 
                 Aug. 5, 2004 
               
               
                 1393 
                 Table_1393_FL_1792_log_signal.txt 
                 720,113 
                 Aug. 5, 2004 
               
               
                 1394 
                 Table_1394_FL_1795_log_signal.txt 
                 720,070 
                 Aug. 5, 2004 
               
               
                 1395 
                 Table_1395_FL_1797_log_signal.txt 
                 719,894 
                 Aug. 5, 2004 
               
               
                 1396 
                 Table_1396_FL_1799_log_signal.txt 
                 719,604 
                 Aug. 5, 2004 
               
               
                 1397 
                 Table_1397_FL_1810_log_signal.txt 
                 719,706 
                 Aug. 5, 2004 
               
               
                 1398 
                 Table_1398_FL_1811_log_signal.txt 
                 719,977 
                 Aug. 5, 2004 
               
               
                 1399 
                 Table_1399_FL_1825_log_signal.txt 
                 719,804 
                 Aug. 5, 2004 
               
               
                 1400 
                 Table_1400_FL_1827_log_signal.txt 
                 720,030 
                 Aug. 5, 2004 
               
               
                 1401 
                 Table_1401_FL_1828_log_signal.txt 
                 719,848 
                 Aug. 5, 2004 
               
               
                 1402 
                 Table_1402_FL_1829_log_signal.txt 
                 720,004 
                 Aug. 5, 2004 
               
               
                 1403 
                 Table_1403_FL_1830_log_signal.txt 
                 719,927 
                 Aug. 5, 2004 
               
               
                 1404 
                 Table_1404_FL_1833_log_signal.txt 
                 719,917 
                 Aug. 5, 2004 
               
               
                 1405 
                 Table_1405_FL_1834_log_signal.txt 
                 719,704 
                 Aug. 5, 2004 
               
               
                 1406 
                 Table_1406_FL_1835_log_signal.txt 
                 720,043 
                 Aug. 5, 2004 
               
               
                 1407 
                 Table_1407_FL_1836_log_signal.txt 
                 719,753 
                 Aug. 5, 2004 
               
               
                 1408 
                 Table_1408_FL_1837_log_signal.txt 
                 719,848 
                 Aug. 5, 2004 
               
               
                 1409 
                 Table_1409_FL_1838_log_signal.txt 
                 719,787 
                 Aug. 5, 2004 
               
               
                 1410 
                 Table_1410_FL_1839_log_signal.txt 
                 719,992 
                 Aug. 5, 2004 
               
               
                 1411 
                 Table_1411_FL_1841_log_signal.txt 
                 719,730 
                 Aug. 5, 2004 
               
               
                 1412 
                 Table_1412_FL_1842_log_signal.txt 
                 719,710 
                 Aug. 5, 2004 
               
               
                 1413 
                 Table_1413_FL_1844_log_signal.txt 
                 719,997 
                 Aug. 5, 2004 
               
               
                 1414 
                 Table_1414_FL_1845_log_signal.txt 
                 720,016 
                 Aug. 5, 2004 
               
               
                 1415 
                 Table_1415_FL_1846_log_signal.txt 
                 719,892 
                 Aug. 5, 2004 
               
               
                 1416 
                 Table_1416_FL_1848_log_signal.txt 
                 719,625 
                 Aug. 5, 2004 
               
               
                 1417 
                 Table_1417_FL_1850_log_signal.txt 
                 720,047 
                 Aug. 5, 2004 
               
               
                 1418 
                 Table_1418_FL_1851_log_signal.txt 
                 719,908 
                 Aug. 5, 2004 
               
               
                 1419 
                 Table_1419_FL_1853_log_signal.txt 
                 719,968 
                 Aug. 5, 2004 
               
               
                 1420 
                 Table_1420_FL_1854_log_signal.txt 
                 720,215 
                 Aug. 5, 2004 
               
               
                 1421 
                 Table_1421_FL_1855_log_signal.txt 
                 719,792 
                 Aug. 5, 2004 
               
               
                 1422 
                 Table_1422_FL_1857_log_signal.txt 
                 719,977 
                 Aug. 5, 2004 
               
               
                 1423 
                 Table_1423_FL_1861_log_signal.txt 
                 719,995 
                 Aug. 5, 2004 
               
               
                 1424 
                 Table_1424_FL_1862_log_signal.txt 
                 719,838 
                 Aug. 5, 2004 
               
               
                 1425 
                 Table_1425_FL_1863_log_signal.txt 
                 719,960 
                 Aug. 5, 2004 
               
               
                 1426 
                 Table_1426_FL_1864_log_signal.txt 
                 720,101 
                 Aug. 5, 2004 
               
               
                 1427 
                 Talee_1427_FL_1866_log_signal.txt 
                 719,826 
                 Aug. 5, 2004 
               
               
                 1428 
                 Table_1428_FL_1870_log_signal.txt 
                 719,906 
                 Aug. 5, 2004 
               
               
                 1429 
                 Table_1429_FL_1873_log_signal.txt 
                 719,826 
                 Aug. 5, 2004 
               
               
                 1430 
                 Table_1430_FL_1874_log_signal.txt 
                 719,987 
                 Aug. 5, 2004 
               
               
                 1431 
                 Table_1431_FL_1876_log_signal.txt 
                 719,955 
                 Aug. 5, 2004 
               
               
                 1432 
                 Table_1432_FL_1879_log_signal.txt 
                 720,033 
                 Aug. 5, 2004 
               
               
                 1433 
                 Table_1433_FL_1880_log_signal.txt 
                 719,838 
                 Aug. 5, 2004 
               
               
                 1434 
                 Table_1434_FL_1382_log_signal.txt 
                 719,856 
                 Aug. 5, 2004 
               
               
                 1435 
                 Table_1435_FL_1884_log_signal.txt 
                 720,054 
                 Aug. 5, 2004 
               
               
                 1436 
                 Table_1436_FL_1885_log_signal.txt 
                 720,091 
                 Aug. 5, 2004 
               
               
                 1437 
                 Table_1437_FL_1887_log_signal.txt 
                 719,999 
                 Aug. 5, 2004 
               
               
                 1438 
                 Table_1438_FL_1888_log_signal.txt 
                 719,870 
                 Aug. 5, 2004 
               
               
                 1439 
                 Table_1439_FL_1890_log_signal.txt 
                 719,775 
                 Aug. 5, 2004 
               
               
                 1440 
                 Table_1440_FL_1894_log_signal.txt 
                 719,951 
                 Aug. 5, 2004 
               
               
                 1441 
                 Table_1441_FL_1896_log_signal.txt 
                 719,806 
                 Aug. 5, 2004 
               
               
                 1442 
                 Table_1442_FL_1897_log_signal.txt 
                 719,814 
                 Aug. 5, 2004 
               
               
                 1443 
                 Table_1443_FL_1898_log_signal.txt 
                 719,896 
                 Aug. 5, 2004 
               
               
                 1444 
                 Table_1444_FL_1900_log_signal.txt 
                 719,881 
                 Aug. 5, 2004 
               
               
                 1445 
                 Table_1445_FL_1903_log_signal.txt 
                 719,743 
                 Aug. 5, 2004 
               
               
                 1446 
                 Table_1446_FL_1904_log_signal.txt 
                 719,937 
                 Aug. 5, 2004 
               
               
                 1447 
                 Table_1447_FL_1905_log_signal.txt 
                 720,014 
                 Aug. 5, 2004 
               
               
                 1448 
                 Table_1448_FL_1906_log_signal.txt 
                 719,525 
                 Aug. 5, 2004 
               
               
                 1449 
                 Table_1449_FL_1907_log_signal.txt 
                 719,495 
                 Aug. 5, 2004 
               
               
                 1450 
                 Table_1450_FL_1910_log_signal.txt 
                 719,730 
                 Aug. 5, 2004 
               
               
                 1451 
                 Table_1451_FL_1912_log_signal.txt 
                 720,188 
                 Aug. 5, 2004 
               
               
                 1452 
                 Table_1452_FL_1913_log_signal.txt 
                 719,864 
                 Aug. 5, 2004 
               
               
                 1453 
                 Table_1453_FL_1916_log_signal.txt 
                 719,705 
                 Aug. 5, 2004 
               
               
                 1454 
                 Table_1454_FL_1918_log_signal.txt 
                 719,919 
                 Aug. 5, 2004 
               
               
                 1455 
                 Table_1455_FL_1919_log_signal.txt 
                 719,819 
                 Aug. 5, 2004 
               
               
                 1456 
                 Table_1456_FL_735_log_signal.txt 
                 719,892 
                 Aug. 5, 2004 
               
               
                 1457 
                 Table_1457_FL_738_log_signal.txt 
                 719,735 
                 Aug. 5, 2004 
               
               
                 1458 
                 Table_1458_FL_739_log_signal.txt 
                 719,983 
                 Aug. 5, 2004 
               
               
                 1459 
                 Table_1459_FL_878_log_signal.txt 
                 719,976 
                 Aug. 5, 2004 
               
               
                 1460 
                 Table_1460_FL_879_log_signal.txt 
                 719,738 
                 Aug. 5, 2004 
               
               
                 1461 
                 Table_1461_FL_886_log_signal.txt 
                 719,991 
                 Aug. 5, 2004 
               
               
                 1462 
                 Table_1462_FL_888_log_signal.txt 
                 719,876 
                 Aug. 5, 2004 
               
               
                 1463 
                 Table_1463_GCB_1005_log_signal.txt 
                 719,924 
                 Aug. 5, 2004 
               
               
                 1464 
                 Table_1464_GCB_1008_log_signal.txt 
                 719,529 
                 Aug. 5, 2004 
               
               
                 1465 
                 Table_1465_GCB_1009_log_signal.txt 
                 719,942 
                 Aug. 5, 2004 
               
               
                 1466 
                 Table_1466_GCB_1021_log_signal.txt 
                 719,714 
                 Aug. 5, 2004 
               
               
                 1467 
                 Table_1467_GCB_1025_log_signal.txt 
                 719,756 
                 Aug. 5, 2004 
               
               
                 1468 
                 Table_1468_GCB_1026_log_signal.txt 
                 719,819 
                 Aug. 5, 2004 
               
               
                 1469 
                 Table_1469_GCB_1037_log_signal.txt 
                 719,756 
                 Aug. 5, 2004 
               
               
                 1470 
                 Table_1470_GCB_1039_log_signal.txt 
                 719,940 
                 Aug. 5, 2004 
               
               
                 1471 
                 Table_1471_GCB_1049_log_signal.txt 
                 719,794 
                 Aug. 5, 2004 
               
               
                 1472 
                 Table_1472_GCB_1051_log_signal.txt 
                 719,894 
                 Aug. 5, 2004 
               
               
                 1473 
                 Table_1473_GCB_1058_log_signal.txt 
                 719,709 
                 Aug. 5, 2004 
               
               
                 1474 
                 Table_1474_GCB_1060_log_signal.txt 
                 719,801 
                 Aug. 5, 2004 
               
               
                 1475 
                 Table_1475_GCB_1990_log_signal.txt 
                 719,399 
                 Aug. 5, 2004 
               
               
                 1476 
                 Table_1476_GCB_1991_log_signal.txt 
                 719,470 
                 Aug. 5, 2004 
               
               
                 1477 
                 Table_1477_GCB_2017_log_signal.txt 
                 719,443 
                 Aug. 5, 2004 
               
               
                 1478 
                 Table_1478_GCB_2018_log_signal.txt 
                 719,412 
                 Aug. 5, 2004 
               
               
                 1479 
                 Table_1479_GCB_2095_log_signal.txt 
                 720,035 
                 Aug. 5, 2004 
               
               
                 1480 
                 Table_1480_GCB_412_log_signal.txt 
                 719,843 
                 Aug. 5, 2004 
               
            
           
           
               
            
               
                 Disc 21 of 22 
               
            
           
           
               
               
               
               
            
               
                 1481 
                 Table_1481_GCB_415_log_signal.txt 
                 719,852 
                 Aug. 5, 2004 
               
               
                 1482 
                 Table_1482_GCB_421_log_signal.txt 
                 719,661 
                 Aug. 5, 2004 
               
               
                 1483 
                 Table_1483_GCB_424_log_signal.txt 
                 719,871 
                 Aug. 5, 2004 
               
               
                 1484 
                 Table_1484_GCB_433_log_signal.txt 
                 719,698 
                 Aug. 5, 2004 
               
               
                 1485 
                 Table_1485_GCB_434_log_signal.txt 
                 719,894 
                 Aug. 5, 2004 
               
               
                 1486 
                 Table_1486_GCB_438_log_signal.txt 
                 719,648 
                 Aug. 5, 2004 
               
               
                 1487 
                 Table_1487_GCB_439_log_signal.txt 
                 719,722 
                 Aug. 5, 2004 
               
               
                 1488 
                 Table_1488_GCB_459_log_signal.txt 
                 719,742 
                 Aug. 5, 2004 
               
               
                 1489 
                 Table_1489_GCB_470_log_signal.txt 
                 719,565 
                 Aug. 5, 2004 
               
               
                 1490 
                 Table_1490_GCB_479_log_signal.txt 
                 719,713 
                 Aug. 5, 2004 
               
               
                 1491 
                 Table_1491_GCB_492_log_signal.txt 
                 719,491 
                 Aug. 5, 2004 
               
               
                 1492 
                 Tabl8_1492_GCB_517_log_signal.txt 
                 719,595 
                 Aug. 5, 2004 
               
               
                 1493 
                 Table_1493_GCB_523_log_signal.txt 
                 719,784 
                 Aug. 5, 2004 
               
               
                 1494 
                 Table_1494_GCB_524_log_signal.txt 
                 719,991 
                 Aug. 5, 2004 
               
               
                 1495 
                 Table_1495_GCB_529_log_signal.txt 
                 719,591 
                 Aug. 5, 2004 
               
               
                 1498 
                 Table_1496_GCB_533_log_signal.txt 
                 719,489 
                 Aug. 5, 2004 
               
               
                 1497 
                 Table_1497_GCB_537_log_signal.txt 
                 719,866 
                 Aug. 5, 2004 
               
               
                 1498 
                 Table_1498_GCB_543_log_signal.txt 
                 719,868 
                 Aug. 5, 2004 
               
               
                 1499 
                 Table_1499_GCB_545_log_signal.txt 
                 719,723 
                 Aug. 5, 2004 
               
               
                 1500 
                 Table_1500_GCB_549_log_signal.txt 
                 719,961 
                 Aug. 5, 2004 
               
               
                 1501 
                 Table_1501_GCB_550_log_signal,txt 
                 719,631 
                 Aug. 5, 2004 
               
               
                 1502 
                 Table_1502_GCB_553_log_signal.txt 
                 719,658 
                 Aug. 5, 2004 
               
               
                 1503 
                 Table_1503_GCB_565_log_signal.txt 
                 719,779 
                 Aug. 5, 2004 
               
               
                 1504 
                 Table_1504_GCB_572_log_signal.txt 
                 719,880 
                 Aug. 5, 2004 
               
               
                 1505 
                 Table_1505_GCB_817_log_signal.txt 
                 719,961 
                 Aug. 5, 2004 
               
               
                 1506 
                 Table_1506_GCB_818_log_signal.txt 
                 719,784 
                 Aug. 5, 2004 
               
               
                 1507 
                 Table_1507_GCB_619_log_signal.txt 
                 719,917 
                 Aug. 5, 2004 
               
               
                 1508 
                 Table_1508_GCB_623_log_signal.txt 
                 719,983 
                 Aug. 5, 2004 
               
               
                 1509 
                 Table_1509_GCB_627_log_signal.txt 
                 719,791 
                 Aug. 5, 2004 
               
               
                 1510 
                 Table_1510_GCB_654_log_signal.txt 
                 719,680 
                 Aug. 5, 2004 
               
               
                 1511 
                 Table_1511_GCB_661_log_signal.txt 
                 719,750 
                 Aug. 5, 2004 
               
               
                 1512 
                 Table_1512_GCB_689_log_signal.txt 
                 719,804 
                 Aug. 5, 2004 
               
               
                 1513 
                 Table_1513_GCB_672_log_signal.txt 
                 719,690 
                 Aug. 5, 2004 
               
               
                 1514 
                 Table_1514_GCB_674_log_signal.txt 
                 719,705 
                 Aug. 5, 2004 
               
               
                 1515 
                 Table_1515_GCB_675_log_signal.txt 
                 719,403 
                 Aug. 5, 2004 
               
               
                 1516 
                 Table_1516_GCB_681_log_signal.txt 
                 719,662 
                 Aug. 5, 2004 
               
               
                 1517 
                 Table_1517_GCB_688_log_signal.txt 
                 719,901 
                 Aug. 5, 2004 
               
               
                 1518 
                 Table_1518_GCB_695_log_signal.txt 
                 719,669 
                 Aug. 5, 2004 
               
               
                 1519 
                 Table_1519_GCB_698_log_signal.txt 
                 719,863 
                 Aug. 5, 2004 
               
               
                 1520 
                 Table_1520_GCB_701_log_signal.txt 
                 719,936 
                 Aug. 5, 2004 
               
               
                 1521 
                 Table_1521_GCB_710_log_signal.txt 
                 719,846 
                 Aug. 5, 2004 
               
               
                 1522 
                 Table_1522_GCB_711_log_signal.txt 
                 719,611 
                 Aug. 5, 2004 
               
               
                 1523 
                 Table_1523_GCB_722_log_signal.txt 
                 719,778 
                 Aug. 5, 2004 
               
               
                 1524 
                 Table_1524_GCB_724_log_signal.txt 
                 719,711 
                 Aug. 5, 2004 
               
               
                 1525 
                 Table_1525_GCB_731_log_signal.txt 
                 719,984 
                 Aug. 5, 2004 
               
               
                 1526 
                 Table_1526_GCB_742_log_signal.txt 
                 719,996 
                 Aug. 5, 2004 
               
               
                 1527 
                 Table_1527_GCB_744_log_signal.txt 
                 719,908 
                 Aug. 5, 2004 
               
               
                 1528 
                 Table_1528_GCB_745_log_signal.txt 
                 719,873 
                 Aug. 5, 2004 
               
               
                 1529 
                 Table_1529_GCB_747_log_signal.txt 
                 719,969 
                 Aug. 5, 2004 
               
               
                 1530 
                 Table_1530_GCB_749_log_signal.txt 
                 719,685 
                 Aug. 5, 2004 
               
               
                 1531 
                 Table_1531_GCB_758_log_signal.txt 
                 719,776 
                 Aug. 5, 2004 
               
               
                 1532 
                 Table_1532_GCB_772_log_signal.txt 
                 720,003 
                 Aug. 5, 2004 
               
               
                 1533 
                 Table_1533_GCB_777_log_signal.txt 
                 719,908 
                 Aug. 5, 2004 
               
               
                 1534 
                 Table_1534_GCB_792_log_signal.txt 
                 719,971 
                 Aug. 5, 2004 
               
               
                 1535 
                 Table_1535_GCB_795_log_signal.txt 
                 719,759 
                 Aug. 5, 2004 
               
               
                 1536 
                 Table_1536_GCB_797_log_signal.txt 
                 719,760 
                 Aug. 6, 2004 
               
               
                 1537 
                 Table_1537_GCB_803_log_signal.txt 
                 719,974 
                 Aug. 6, 2004 
               
               
                 1538 
                 Table_1538_GCB_810_log_signal.txt 
                 719,852 
                 Aug. 5, 2004 
               
               
                 1539 
                 Table_1539_GCB_817_log_signal.txt 
                 719,764 
                 Aug. 5, 2004 
               
               
                 1540 
                 Table_1540_GCB_818_log_signal.txt 
                 719,583 
                 Aug. 5, 2004 
               
               
                 1541 
                 Table_1541_GCB_819_log_signal.txt 
                 719,786 
                 Aug. 5, 2004 
               
               
                 1542 
                 Table_1542_GCB_821_log_signal.txt 
                 719,744 
                 Aug. 5, 2004 
               
               
                 1543 
                 Table_1543_GCB_832_log_signal.txt 
                 719,702 
                 Aug. 5, 2004 
               
               
                 1544 
                 Table_1544_GCB_836_log_signal.txt 
                 719,639 
                 Aug. 5, 2004 
               
               
                 1545 
                 Table_1545_GCB_840_log_signal.txt 
                 720,192 
                 Aug. 5, 2004 
               
               
                 1546 
                 Table_1546_GCB_847_log_signal.txt 
                 719,894 
                 Aug. 5, 2004 
               
               
                 1547 
                 Table_1547_GCB_860_log_signal.txt 
                 719,781 
                 Aug. 5, 2004 
               
               
                 1548 
                 Table_1548_GCB_871_log_signal.txt 
                 719,867 
                 Aug. 5, 2004 
               
               
                 1549 
                 Table_1549_GCB_874_log_signal.txt 
                 719,863 
                 Aug. 5, 2004 
               
               
                 1550 
                 Table_1550_GCB_995_log_signal.txt 
                 719,901 
                 Aug. 5, 2004 
               
               
                 1551 
                 Table_1551_LPC_2224_log_signal.txt 
                 719,928 
                 Aug. 5, 2004 
               
               
                 1552 
                 Table_1552_LPC_2232_log_signal.txt 
                 720,084 
                 Aug. 5, 2004 
               
               
                 1553 
                 Table_1553_LPC_2261_log_signal.txt 
                 719,850 
                 Aug. 5, 2004 
               
               
                 1554 
                 Table_1554_LPC_2262_log_signal.txt 
                 720,236 
                 Aug. 5, 2004 
               
               
                 1555 
                 Table_1555_LPC_2263_log_signal.txt 
                 720,029 
                 Aug. 5, 2004 
               
               
                 1556 
                 Table_1556_LPC_2265_log_signal.txt 
                 719,906 
                 Aug. 5, 2004 
               
               
                 1557 
                 Table_1557_Lymbl_2185_log_signal.txt 
                 719,715 
                 Aug. 5, 2004 
               
               
                 1558 
                 Table_1558_Lymbl_2186_log_signal.txt 
                 719,629 
                 Aug. 5, 2004 
               
               
                 1559 
                 Table_1559_Lymbl_2249_log_signal.txt 
                 720,127 
                 Aug. 5, 2004 
               
               
                 1560 
                 Table_1560_MALT_Gastric_2021_log_signal.txt 
                 719,609 
                 Aug. 5, 2004 
               
               
                 1561 
                 Table_1561_MALT_Gastric_2041_log_signal.txt 
                 719,769 
                 Aug. 5, 2004 
               
               
                 1562 
                 Table_1562_MALT_Gastric_2065_log_signal.txt 
                 719,679 
                 Aug. 5, 2004 
               
               
                 1563 
                 Table_1563_MALT_Gastric_2067_log_signal.txt 
                 719,927 
                 Aug. 5, 2004 
               
               
                 1564 
                 Table_1564_MALT_Gastric_2070_log_signal.txt 
                 719,871 
                 Aug. 5, 2004 
               
               
                 1565 
                 Table_1565_MALT_Gastric_2110_log_signal.txt 
                 719,932 
                 Aug. 5, 2004 
               
               
                 1566 
                 Table_1566_MALT_Gastric_2111_log_signal.txt 
                 719,305 
                 Aug. 5, 2004 
               
               
                 1567 
                 Table_1567_MALT_Gastric_2112_log_signal.txt 
                 719,897 
                 Aug. 5, 2004 
               
               
                 1568 
                 Table_1568_MALT_Gastric_2270_log_signal.txt 
                 719,916 
                 Aug. 5, 2004 
               
               
                 1569 
                 Table_1569_MALT_lung_2202_log_signal.txt 
                 720,174 
                 Aug. 5, 2004 
               
               
                 1570 
                 Table_1570_MALT_salivary_2243_log_signal.txt 
                 720,111 
                 Aug. 5, 2004 
               
               
                 1571 
                 Table_1571_MALT_tonsil_2211_log_signal.txt 
                 720,102 
                 Aug. 5, 2004 
               
               
                 1572 
                 Table_1572_MALT_unk_2178_log_signal.txt 
                 719,940 
                 Aug. 5, 2004 
               
               
                 1573 
                 Table_1573_MALT_unk_2182_log_signal.txt 
                 719,681 
                 Aug. 5, 2004 
               
               
                 1574 
                 Table_1574_MALT_unk_2183_log_signal.txt 
                 720,031 
                 Aug. 5, 2004 
               
               
                 1575 
                 Table_1575_MALT_unk_2184_log_signal.txt 
                 720,023 
                 Aug. 5, 2004 
               
               
                 1576 
                 Table_1576_MCL_1012_log_signal.txt 
                 719,967 
                 Aug. 5, 2004 
               
               
                 1577 
                 Table_1577_MCL_1091_log_signal.txt 
                 719,861 
                 Aug. 5, 2004 
               
               
                 1578 
                 Table_1578_MCL_1114_log_signal.txt 
                 720,107 
                 Aug. 5, 2004 
               
               
                 1579 
                 Table_1579_MCL_1128_log_sighal.txt 
                 719,887 
                 Aug. 5, 2004 
               
               
                 1580 
                 Table_1580_MCL_1150_log_signal.txt 
                 719,990 
                 Aug. 5, 2004 
               
               
                 1581 
                 Table_1581_MCL_1162_log_signal.txt 
                 719,887 
                 Aug. 5, 2004 
               
               
                 1582 
                 Table_1582_MCL_1166_log_signal.txt 
                 719,942 
                 Aug. 5, 2004 
               
               
                 1583 
                 Table_1583_MCL_1194_log_signal.txt 
                 719,765 
                 Aug. 5, 2004 
               
               
                 1584 
                 Table_1584_MCL_885_log_signal.txt 
                 719,947 
                 Aug. 5, 2004 
               
               
                 1585 
                 Table_1585_MCL_918_log_signal.txt 
                 719,871 
                 Aug. 5, 2004 
               
               
                 1586 
                 Table_1586_MCL_924_log_signal.txt 
                 729,318 
                 Aug. 5, 2004 
               
               
                 1587 
                 Table_1587_MCL_925_log_signal.txt 
                 719,991 
                 Aug. 5, 2004 
               
               
                 1588 
                 Table_1588_MCL_926_log_signal.txt 
                 720,109 
                 Aug. 5, 2004 
               
               
                 1589 
                 Table_1589_MCL_936_log_signal.txt 
                 720,025 
                 Aug. 5, 2004 
               
               
                 1590 
                 Table_1590_MCL_939_log_signal.txt 
                 720,025 
                 Aug. 5, 2004 
               
               
                 1591 
                 Table_1591_MCL_953_log_signal.txt 
                 719,562 
                 Aug. 5, 2004 
               
               
                 1592 
                 Table_1592_MCL_956_log_signal.txt 
                 719,923 
                 Aug. 5, 2004 
               
               
                 1593 
                 Table_1593_MCL_964_log_signal.txt 
                 719,968 
                 Aug. 5, 2004 
               
               
                 1594 
                 Table_1594_MCL_966_log_signal.txt 
                 719,679 
                 Aug. 5, 2004 
               
               
                 1595 
                 Table_1595_MCL_968_log_signal.txt 
                 719,778 
                 Aug. 5, 2004 
               
               
                 1596 
                 Table_1596_MCL_970_log_signal.txt 
                 719,737 
                 Aug. 5, 2004 
               
               
                 1597 
                 Table_1597_Mult_Myeloma_H1112_100001_log_signal.txt 
                 719,421 
                 Aug. 5, 2004 
               
               
                 1598 
                 Table_1598_Mult_Myeloma_HDLM2_100002_log_signal.txt 
                 719,052 
                 Aug. 5, 2004 
               
               
                 1599 
                 Table_1599_Mult_Myeloma_JIM3_100003_log_signal.txt 
                 719,345 
                 Aug. 5, 2004 
               
               
                 1600 
                 Table_1600_Mult_Myeloma_JJN3_100004_log_signal.txt 
                 719,543 
                 Aug. 5, 2004 
               
               
                 1601 
                 Table_1601_Mult_Myeloma_KMS11_100005_log_signal.txt 
                 719,485 
                 Aug. 5, 2004 
               
               
                 1602 
                 Table_1602_Mult_Myeloma_KMS12_100006_log_signal.txt 
                 719,226 
                 Aug. 5, 2004 
               
               
                 1603 
                 Table_1603_Mult_Myeloma_LB84_1_100007_log_signal.txt 
                 719,446 
                 Aug. 5, 2004 
               
               
                 1604 
                 Table_1604_Mult_Myeloma_LP1_100008_log_signal.txt 
                 719,215 
                 Aug. 5, 2004 
               
               
                 1605 
                 Table_1505_Mult_Myeloma_U266_100009_log_signal.txt 
                 719,709 
                 Aug. 5, 2004 
               
               
                 1606 
                 Table_1606_NMZ_2231_log_signal.txt 
                 720,065 
                 Aug. 5, 2004 
               
               
                 1607 
                 Table_1607_NMZ_2242_log_signal.txt 
                 719,936 
                 Aug. 5, 2004 
               
               
                 1608 
                 Table_1608_NMZ_2254_log_signal.txt 
                 719,889 
                 Aug. 5, 2004 
               
               
                 1609 
                 Table_1609_PMBL_1006_log_signal.txt 
                 719,569 
                 Aug. 5, 2004 
               
               
                 1610 
                 Table_1610_PMBL_1024_log_signal.txt 
                 719,689 
                 Aug. 5, 2004 
               
               
                 1611 
                 Table_1611_PMBL_1048_log_signal.txt 
                 719,535 
                 Aug. 5, 2004 
               
               
                 1612 
                 Table_1612_PMBL_1053_log_signal.txt 
                 719,833 
                 Aug. 5, 2004 
               
               
                 1613 
                 Table_1613_PMBL_1920_log_signal.txt 
                 719,681 
                 Aug. 5, 2004 
               
               
                 1614 
                 Table_1614_PMBL_1921_log_signal.txt 
                 719,749 
                 Aug. 5, 2004 
               
               
                 1615 
                 Table_1615_PMBL_1923_log_signal.txt 
                 719,681 
                 Aug. 5, 2004 
               
               
                 1616 
                 Table_1616_PMBL_1924_log_signal.txt 
                 719,659 
                 Aug. 5, 2004 
               
               
                 1617 
                 Table_1617_PMBL_1935_log_signal.txt 
                 719,716 
                 Aug. 5, 2004 
               
               
                 1618 
                 Table_1618_PMBL_1941_log_signal.txt 
                 719,793 
                 Aug. 5, 2004 
               
               
                 1619 
                 Table_1619_PMBL_1942_log_signal.txt 
                 719,S57 
                 Aug. 5, 2004 
               
               
                 1620 
                 Table_1620_PMBL_1943_log_signal.txt 
                 719,523 
                 Aug. 5, 2004 
               
               
                 1621 
                 Table_1621_PMBL_1945_log_signal.txt 
                 719,389 
                 Aug. 5, 2004 
               
               
                 1622 
                 Table_1622_PMBL_1948_log_signal.txt 
                 719,581 
                 Aug. 5, 2004 
               
               
                 1623 
                 Table_1623_PMBL_1949_log_signal.txt 
                 719,805 
                 Aug. 5, 2004 
               
               
                 1624 
                 Table_1624_PMBL_1989_log_signal.txt 
                 719,642 
                 Aug. 5, 2004 
               
               
                 1625 
                 Table_1625_PMBL_1992_log_signal.txt 
                 719,564 
                 Aug. 5, 2004 
               
               
                 1626 
                 Table_1626_PMBL_1993_log_signal.txt 
                 719,621 
                 Aug. 5, 2004 
               
               
                 1627 
                 Table_1627_PMBL_2002_log_signal.txt 
                 719,718 
                 Aug. 5, 2004 
               
               
                 1628 
                 Table_1628_PMBL_2019_log_signal.txt 
                 719,547 
                 Aug. 5, 2004 
               
               
                 1629 
                 Table_1629_PMBL_2020_log_signal.txt 
                 719,620 
                 Aug. 5, 2004 
               
               
                 1630 
                 Table_1630_PMBL_2092_log_signal.txt 
                 719,844 
                 Aug. 5, 2004 
               
               
                 1631 
                 Table_1631_PMBL_484_log_signal.txt 
                 719,920 
                 Aug. 5, 2004 
               
               
                 1632 
                 Table_1632_PMBL_546_log_signal.txt 
                 720,204 
                 Aug. 5, 2004 
               
               
                 1683 
                 Table_1633_PMBL_570_log_signal.txt 
                 719,670 
                 Aug. 5, 2004 
               
               
                 1634 
                 Table_1634_PMBL_621_log_signal.txt 
                 719,915 
                 Aug. 5, 2004 
               
               
                 1635 
                 Table_1635_PMBL_638_log_signal.txt 
                 719,798 
                 Aug. 5, 2004 
               
               
                 1636 
                 Table_1636_PMBL_691_log_signal.txt 
                 719,763 
                 Aug. 5, 2004 
               
               
                 1637 
                 Table_1637_PMBL_791_log_signal.txt 
                 719,762 
                 Aug. 5, 2004 
               
               
                 1638 
                 Table_1638_PMBL_824_log_signal.txt 
                 719,876 
                 Aug. 5, 2004 
               
               
                 1639 
                 Table_1639_PMBL_906_log_signal.txt 
                 719,758 
                 Aug. 5, 2004 
               
               
                 1640 
                 Table_1640_PMBL_994_log_signal.txt 
                 719,755 
                 Aug. 5, 2004 
               
               
                 1641 
                 Table_1641_PMBL_998_log_signal.txt 
                 719,786 
                 Aug. 5, 2004 
               
               
                 1642 
                 Table_1642_PTLD_1817_log_signal.txt 
                 719,584 
                 Aug. 5, 2004 
               
               
                 1643 
                 Tabl8_1643_PTLD_1824_log_signal.txt 
                 719,6Z6 
                 Aug. 5, 2004 
               
               
                 1644 
                 Table_1644_PTLD_1981_log_signal.txt 
                 719,522 
                 Aug. 5, 2004 
               
               
                 1645 
                 Table_1645_PTLD_1986_log_signal.txt 
                 719,870 
                 Aug. 5, 2004 
               
               
                 1646 
                 Table_1646_SLL_1151_log_signal.txt 
                 719,912 
                 Aug. 5, 2004 
               
               
                 1647 
                 Table_1647_SLL_1153_log_signal.txt 
                 720,059 
                 Aug. 5, 2004 
               
               
                 1648 
                 Table_1648_SLL_1155_log_signal.txt 
                 720,031 
                 Aug. 5, 2004 
               
               
                 1649 
                 Table_1649_SLL_1156_log_signal.txt 
                 720,140 
                 Aug. 5, 2004 
               
               
                 1650 
                 Table_1650_SLL_1158_log_signal.txt 
                 720,029 
                 Aug. 5, 2004 
               
               
                 1651 
                 Table_1651_SLL_1213_log_signal.txt 
                 720,069 
                 Aug. 5, 2004 
               
               
                 1652 
                 Table_1652_SLL_1214_log_signal.txt 
                 719,849 
                 Aug. 5, 2004 
               
               
                 1653 
                 Table_1653_SLL_1216_log_signal.txt 
                 719,817 
                 Aug. 5, 2004 
               
               
                 1654 
                 Table_1654_SLL_1217_log_signal.txt 
                 719,829 
                 Aug. 5, 2004 
               
               
                 1655 
                 Table_1655_SLL_1218_log_signal.txt 
                 719,694 
                 Aug. 5, 2004 
               
               
                 1656 
                 Table_1656_SLL_1220_log_signal.txt 
                 719,763 
                 Aug. 5, 2004 
               
               
                 1657 
                 Table_1657_SLL_1229_log_signal.txt 
                 719,434 
                 Aug. 5, 2004 
               
               
                 1658 
                 Table_1658_SLL_1231_log_signal.txt 
                 719,688 
                 Aug. 5, 2004 
               
               
                 1659 
                 Table_1659_SLL_1235_log_signal.txt 
                 719,578 
                 Aug. 5, 2004 
               
               
                 1660 
                 Table_1660_SLL_1236_log_signal.txt 
                 719,791 
                 Aug. 5, 2004 
               
               
                 1661 
                 Table_1661_SLL_1238_log_signal.txt 
                 719,633 
                 Aug. 5, 2004 
               
               
                 1662 
                 Table_1662_SLL_1240_log_signal.txt 
                 719,788 
                 Aug. 5, 2004 
               
               
                 1663 
                 Table_1663_Splenic_2061_log_signal.txt 
                 719,871 
                 Aug. 5, 2004 
               
               
                 1664 
                 Table_1664_Splenic_2074_log_signal.txt 
                 720,044 
                 Aug. 5, 2004 
               
               
                 1665 
                 Table_1665_Splenic_2075_log_signal.txt 
                 719,895 
                 Aug. 5, 2004 
               
               
                 1666 
                 Table_1666_Splenic_2077_log_signal.txt 
                 720,030 
                 Aug. 5, 2004 
               
               
                 1667 
                 Table_1667_Splenic_2079_log_signal.txt 
                 719,789 
                 Aug. 5, 2004 
               
               
                 1668 
                 Table_1668_Splenic_2104_log_signal.txt 
                 719,813 
                 Aug. 5, 2004 
               
               
                 1669 
                 Table_1669_Splenic_2105_log_signal.txt 
                 720,016 
                 Aug. 5, 2004 
               
               
                 1670 
                 Table_1670_Splenic_2106_log_signal.txt 
                 719,757 
                 Aug. 5, 2004 
               
               
                 1671 
                 Table_1671_Splenic_2256_log_signal.txt 
                 720,008 
                 Aug. 5, 2004 
               
               
                 1672 
                 Table_1672_Splenic_2257_log_signal.txt 
                 719,730 
                 Aug. 5, 2004 
               
               
                 1673 
                 Table_1673_Splenic_2258_log_signal.txt 
                 719,797 
                 Aug. 5, 2004 
               
               
                 1674 
                 Table_1674_Splenic_2259_log_signal.txt 
                 719,978 
                 Aug. 5, 2004 
               
               
                 1675 
                 Table_1675_Splenic_2260_log_signal.txt 
                 719,700 
                 Aug. 5, 2004 
               
               
                 1676 
                 Table_1676_UC_DLBCL_1001_log_signal.txt 
                 719,781 
                 Aug. 5, 2004 
               
               
                 1677 
                 Table_1677_UC_DLBCL_1004_log_signal.txt 
                 719,748 
                 Aug. 5, 2004 
               
               
                 1678 
                 Table_1678_UC_DLBCL_1007_log_signal.txt 
                 719,736 
                 Aug. 5, 2004 
               
               
                 1679 
                 Table_1679_UC_DLBCL_1018_log_signal.txt 
                 719,605 
                 Aug. 5, 2004 
               
               
                 1680 
                 Table_1680_UC_DLBCL_1041_log_signal.txt 
                 719,657 
                 Aug. 5, 2004 
               
               
                 1681 
                 Table_1681_UC_DLBCL_1054_log_signal.txt 
                 719,834 
                 Aug. 5, 2004 
               
               
                 1682 
                 Table_1682_UC_DLBCL_306_log_signal.txt 
                 719,532 
                 Aug. 5, 2004 
               
               
                 1683 
                 Table_1683_UC_DLBCL_310_log_signal.txt 
                 719,704 
                 Aug. 5, 2004 
               
               
                 1684 
                 Table_1684_UC_DLBCL_449_log_signal.txt 
                 719,556 
                 Aug. 5, 2004 
               
               
                 1685 
                 Table_1685_UC_DLBCL_452_log_signal.txt 
                 720,038 
                 Aug. 5, 2004 
               
               
                 1686 
                 Table_1686_UC_DLBCL_458_log_signal.txt 
                 720,003 
                 Aug. 5, 2004 
               
               
                 1687 
                 Table_1687_UC_DLBCL_460_log_signal.txt 
                 719,789 
                 Aug. 5, 2004 
               
               
                 1688 
                 Table_1688_UC_DLBCL_491_log_signal.txt 
                 719,734 
                 Aug. 5, 2004 
               
               
                 1689 
                 Table_1689_UC_DLBCL_528_log_signal.txt 
                 719,715 
                 Aug. 5, 2004 
               
               
                 1690 
                 Table_1690_UC_DLBCL_615_log_signal.txt 
                 719,713 
                 Aug. 5, 2004 
               
               
                 1691 
                 Table_1691_UC_DLBCL_625_log_signal.txt 
                 719,795 
                 Aug. 5, 2004 
               
               
                 1692 
                 Table_1692_UC_DLBCL_664_log_signal.txt 
                 719,885 
                 Aug. 5, 2004 
               
               
                 1693 
                 Table_1693_UC_DLBCL_671_log_signal.txt 
                 719,709 
                 Aug. 5, 2004 
               
               
                 1694 
                 Table_1694_UC_DLBCL_682_log_signal.txt 
                 719,847 
                 Aug. 5, 2004 
               
               
                 1695 
                 Table_1695_UC_DLBCL_683_log_signal.txt 
                 719,809 
                 Aug. 5, 2004 
               
               
                 1696 
                 Table_1696_UC_DLBCL_684_log_signal.txt 
                 719,647 
                 Aug. 5, 2004 
               
               
                 1697 
                 Table_1697_UC_DLBCL_748_log_signal.txt 
                 719,827 
                 Aug. 5, 2004 
               
               
                 1698 
                 Table_1698_UC_DLBCL_751_log_signal.txt 
                 719,759 
                 Aug. 5, 2004 
               
               
                 1699 
                 Table_1699_UC_DLBCL_808_log_signal.txt 
                 719,655 
                 Aug. 5, 2004 
               
               
                 1700 
                 Table_1700_UC_DLBCL_831_log_signal.txt 
                 719,881 
                 Aug. 5, 2004 
               
               
                 1701 
                 Table_1701_UC_DLBCL_834_log_signal.txt 
                 719,550 
                 Aug. 5, 2004 
               
               
                 1702 
                 Table_1702_UC_DLBCL_838_log_signal.txt 
                 719,865 
                 Aug. 5, 2004 
               
               
                 1703 
                 Table_1703_UC_DLBCL_851_log_signal.txt 
                 719,904 
                 Aug. 5, 2004 
               
               
                 1704 
                 Table_1704_UC_DLBCL_854_log_signal.txt 
                 719,912 
                 Aug. 5, 2004 
               
               
                 1705 
                 Table_1705_UC_DLBCL_855_log_signal.txt 
                 719,903 
                 Aug. 5, 2004 
               
               
                 1706 
                 Table_1706_UC_DLBCL_856_log_signal.txt 
                 719,736 
                 Aug. 5, 2004 
               
               
                 1707 
                 Table_1707_ABC_Stats.txt 
                 19,458666 
                 Aug. 22, 2004 
               
               
                 1708 
                 Table_1708_BL_Stats.txt 
                 20,646,028 
                 Aug. 22, 2004 
               
               
                 1709 
                 Table_1709_FH_Stats.txt 
                 20,631,528 
                 Aug. 22, 2004 
               
               
                 1710 
                 Table_1710_FL_Stats.txt 
                 21,832,450 
                 Aug. 22, 2004 
               
               
                 1711 
                 Table_1711_Gastric_MALT_Stats.txt 
                 19,429,850 
                 Aug. 22, 2004 
               
               
                 1712 
                 Table_1712_GCB_Stats.txt 
                 19,460,177 
                 Aug. 22, 2004 
               
               
                 1713 
                 Table_1713_LPC_Stats.txt 
                 20,569,572 
                 Aug. 22, 2004 
               
               
                 1714 
                 Table_1714_Lymbl_Stats.txt 
                 20,624,886 
                 Aug. 22, 2004 
               
               
                 1715 
                 Table_1715_MCL_Stats.txt 
                 21,816,811 
                 Aug. 22, 2004 
               
               
                 1716 
                 Table_1716_Mult_Myeloma_Stats.txt 
                 20,655,192 
                 Aug. 22, 2004 
               
               
                 1717 
                 Table_1717_NMZ_Stats.txt 
                 20,633,800 
                 Aug. 22, 2004 
               
               
                 1718 
                 Table_1718_PMBL_Stats.txt 
                 19,448,976 
                 Aug. 22, 2004 
               
               
                 1719 
                 Table_1719_PTLD_Stats.txt 
                 20,634,040 
                 Aug. 22, 2004 
               
               
                 1720 
                 Table_1720_SLL_Stats.txt 
                 20,625,386 
                 Aug. 22, 2004 
               
               
                 1721 
                 Table_1721_Splenic_Stats.txt 
                 20,608,286 
                 Aug. 22, 2004 
               
               
                 1722 
                 Table_1722_All_MALT_Stats.txt 
                 19,401341 
                 Aug. 22, 2004 
               
               
                 1723 
                 Table_1723_DLBCL_Stats.txt 
                 18,266589 
                 Aug. 22, 2004 
               
               
                 1725 
                 Table_1725_BL_2032_52748.txt 
                 182,232 
                 Aug. 21, 2004 
               
               
                 1726 
                 Table_1726_BL_2033_52749.txt 
                 182,411 
                 Aug. 21, 2004 
               
               
                 1727 
                 Table_1727_BL_2035_52750.txt 
                 182,439 
                 Aug. 21, 2004 
               
               
                 1728 
                 Table_1728_BL_2036_52751.txt 
                 182,419 
                 Aug. 21, 2004 
               
               
                 1729 
                 Table_1729_BL_2037_53294.txt 
                 182,586 
                 Aug. 21, 2004 
               
               
                 1730 
                 Table_1730_BL_2038_52752.txt 
                 182,526 
                 Aug. 21, 2004 
               
               
                 1731 
                 Table_1731_BL_2082_53031.txt 
                 182,367 
                 Aug. 23, 2004 
               
               
                 1732 
                 Table_1732_BL_2083_53293.txt 
                 182,432 
                 Aug. 23, 2004 
               
               
                 1733 
                 Table_1733_BL_2086_52754.txt 
                 182,376 
                 Aug. 23, 2004 
               
               
                 1734 
                 Table_1734_BL_2088_52755.txt 
                 182,485 
                 Aug. 23, 2004 
               
               
                 1735 
                 Table_1735_BL_2090_52758.txt 
                 182,594 
                 Aug. 23, 2004 
               
               
                 1736 
                 Table_1736_BL_2091_52759.txt 
                 182,553 
                 Aug. 23, 2004 
               
               
                 1737 
                 Table_1737_BL_2097_52760.txt 
                 182,456 
                 Aug. 23, 2004 
               
               
                 1738 
                 Table_1738_BL_2099_52761.txt 
                 182,398 
                 Aug. 23, 2004 
               
               
                 1739 
                 Table_1739_BL_2100_52762.txt 
                 182,615 
                 Aug. 23, 2004 
               
               
                 1740 
                 Table_1740_BL_2101_52763.txt 
                 132,545 
                 Aug. 23, 2004 
               
               
                 1741 
                 Table_1741_BL_2103_52764.txt 
                 182,403 
                 Aug. 23, 2004 
               
               
                 1742 
                 Table_1742_BL_2125_52765.txt 
                 182,445 
                 Aug. 23, 2004 
               
               
                 1743 
                 Table_1743_BL_2126_52766.txt 
                 182,313 
                 Aug. 23, 2004 
               
               
                 1744 
                 Table_1744_BL_2127_52767.txt 
                 182,284 
                 Aug. 23, 2004 
               
               
                 1745 
                 Table_1745_BL_2128_52768.txt 
                 182,178 
                 Aug. 23, 2004 
               
               
                 1746 
                 Table_1746_BL_2129_52769.txt 
                 182,403 
                 Aug. 23, 2004 
               
               
                 1747 
                 Table_1747_BL_2267_52770.txt 
                 182,514 
                 Aug. 23, 2004 
               
               
                 1748 
                 Table_1748_BL_2268_52771.txt 
                 182,535 
                 Aug. 23, 2004 
               
               
                 1749 
                 Table_1749_BL_2269_52772.txt 
                 182,371 
                 Aug. 23, 2004 
               
               
                 1750 
                 Table_1750_BL_2271_52773.txt 
                 182,496 
                 Aug. 23, 2004 
               
               
                 1751 
                 Table_1751_BL_2386_53355.txt 
                 182,265 
                 Aug. 23, 2004 
               
               
                 1752 
                 Table_1752_BL_2387_53356.txt 
                 182,708 
                 Aug. 24, 2004 
               
               
                 1753 
                 Table_1753_BL_2388_53357.txt 
                 182,539 
                 Aug. 24, 2004 
               
               
                 1754 
                 Table_1754_BL_2389_53358.txt 
                 182,360 
                 Aug. 24, 2004 
               
               
                 1755 
                 Table_1755_BL_2390_53359.txt 
                 182,449 
                 Aug. 25, 2004 
               
               
                 1756 
                 Table_1756_BL_2391_53360.txt 
                 182,528 
                 Aug. 25, 2004 
               
               
                 1757 
                 Table_1757_BL_2392_53361.txt 
                 182,519 
                 Aug. 25, 2004 
               
               
                 1758 
                 Thbie_1758_BL_2393_53362.txt 
                 182,354 
                 Aug. 25, 2004 
               
               
                 1759 
                 Table_1759_BL_2394_53363.txt 
                 182,321 
                 Aug. 25, 2004 
               
               
                 1760 
                 Table_1760_BL_2395_53364.txt 
                 182,615 
                 Aug. 25, 2004 
               
               
                 1761 
                 Table_1761_BL_2896_53365.txt 
                 182,395 
                 Aug. 25, 2004 
               
               
                 1762 
                 Table_1762_BL_2400_53366.txt 
                 182,611 
                 Aug. 25, 2004 
               
               
                 1763 
                 Table_1763_BL_2402_53367.txt 
                 182,344 
                 Aug. 25, 2004 
               
               
                 1764 
                 Table_1764_BL_2405_53368.txt 
                 182,461 
                 Aug. 25, 2004 
               
               
                 1765 
                 Table_1765_BL_2406_53369.txt 
                 182,368 
                 Aug. 25, 2004 
               
               
                 1766 
                 Table_1766_BL_2409_53370.txt 
                 182,484 
                 Aug. 25, 2004 
               
               
                 1767 
                 Table_1767_BL_2417_53377.txt 
                 182,524 
                 Aug. 25, 2004 
               
               
                 1768 
                 Table_1768_BL_2418_53378.txt 
                 182,353 
                 Aug. 25, 2004 
               
               
                 1769 
                 Table_1769_BL_2419_53379.txt 
                 182,524 
                 Aug. 25, 2004 
               
               
                 1770 
                 Table_1770_BL_2420_53380.txt 
                 182,384 
                 Aug. 25, 2004 
               
               
                 1771 
                 Table_1771_BL_2421_53381.txt 
                 182,445 
                 Aug. 26, 2004 
               
               
                 1772 
                 Table_1772_BL_2422_53382.txt 
                 182,464 
                 Aug. 26, 2004 
               
               
                 1923 
                 Table_1923_DLBCL_669_52074.txt 
                 182,457 
                 Aug. 23, 2004 
               
               
                 1924 
                 Table_1924_DLBCL_671_52075.txt 
                 182,374 
                 Aug. 23, 2004 
               
               
                 1925 
                 Table_1925_DLBCL_672_52076.txt 
                 182,417 
                 Aug. 23, 2004 
               
               
                 1926 
                 Table_1926_DLBCL_674_52004.txt 
                 182,482 
                 Aug. 23, 2004 
               
               
                 1927 
                 Table_1927_DLBCL_675_52095.txt 
                 182,127 
                 Aug. 23, 2004 
               
               
                 1928 
                 Table_1928_DLBCL_676_52977.txt 
                 182,312 
                 Aug. 23, 2004 
               
               
                 1929 
                 Table_1929_DLBCL_678_51829.txt 
                 182,308 
                 Aug. 23, 2004 
               
               
                 1930 
                 Table_1938_DLBCL_681_52152.txt 
                 182,395 
                 Aug. 23, 2004 
               
               
                 1931 
                 Table_1931_DLBCL_882_52154.txt 
                 182,477 
                 Aug. 23, 2004 
               
               
                 1932 
                 Table_1932_DLBCL_683_52153.txt 
                 182,390 
                 Aug. 23, 2004 
               
               
                 1933 
                 Table_1933_DLBCL_684_52155.txt 
                 182,346 
                 Aug. 23, 2004 
               
               
                 1934 
                 Table_1934_DLBCL_687_52077.txt 
                 182,331 
                 Aug. 23, 2004 
               
               
                 1935 
                 Table_1935_DLBCL_688_52078.txt 
                 182,333 
                 Aug. 23, 2004 
               
               
                 1936 
                 Table_1936_DLBCL_689_52079.txt 
                 182,362 
                 Aug. 23, 2004 
               
               
                 1937 
                 Table_1937_DLBCL_692_51825.txt 
                 182,320 
                 Aug. 23, 2004 
               
               
                 1938 
                 Table_1938_DLBCL_694_52080.txt 
                 182,236 
                 Aug. 23, 2004 
               
               
                 1939 
                 Table_1939_DLBCL_695_52081.txt 
                 182,341 
                 Aug. 23, 2004 
               
               
                 1940 
                 Table_1940_DLBCL_698_51828.txt 
                 182,428 
                 Aug. 23, 2004 
               
               
                 1941 
                 Table_1941_DLBCL_700_51835.txt 
                 182,292 
                 Aug. 23, 2004 
               
               
                 1942 
                 Table_1942_DLBCL_701_52244.txt 
                 182,408 
                 Aug. 23, 2004 
               
               
                 1943 
                 Table_1943_DLBCL_702_51834.txt 
                 182,320 
                 Aug. 23, 2004 
               
               
                 1944 
                 Table_1944_DLBCL_704_52082.txt 
                 182,198 
                 Aug. 23, 2004 
               
               
                 1945 
                 Table_1945_DLBCL_709_52123.txt 
                 182,355 
                 Aug. 23, 2004 
               
               
                 1946 
                 Table_1946_DLBCL_710_52122.txt 
                 182,360 
                 Aug. 23, 2004 
               
               
                 1947 
                 Table_1947_DLBCL_711_52083.txt 
                 182,453 
                 Aug. 23, 2004 
               
               
                 1948 
                 Table_1948_DLBCL_712_52084.txt 
                 182,345 
                 Aug. 23, 2004 
               
               
                 1949 
                 Table_1949_DLBCL_714_52125.txt 
                 182,513 
                 Aug. 23, 2004 
               
               
                 1950 
                 Table_1950_DLBCL_717_52124.txt 
                 182,376 
                 Aug. 23, 2004 
               
               
                 1951 
                 Table_1951_DLBCL_722_52181.txt 
                 182,411 
                 Aug. 23, 2004 
               
               
                 1952 
                 Table_1952_DLBCL_724_52978.txt 
                 182,354 
                 Aug. 23, 2004 
               
               
                 1953 
                 Table_1953_DLBCL_725_52979.txt 
                 182,349 
                 Aug. 23, 2004 
               
               
                 1954 
                 Table_1954_DLBCL_726_52980.txt 
                 182,382 
                 Aug. 23, 2004 
               
               
                 1955 
                 Table_1955_DLBCL_730_51833.txt 
                 182,186 
                 Aug. 23, 2004 
               
               
                 1956 
                 Table_1956_DLBCL_731_51832.txt 
                 182,453 
                 Aug. 23, 2004 
               
               
                 1957 
                 Table_1957_DLBCL_742_52085.txt 
                 182,445 
                 Aug. 23, 2004 
               
               
                 1958 
                 Table_1958_DLBCL_744_52086.txt 
                 182,315 
                 Aug. 23, 2004 
               
               
                 1959 
                 Table_1959_DLBCL_745_52096.txt 
                 182,461 
                 Aug. 23, 2004 
               
               
                 1960 
                 Table_1960_DLBCL_747_52097.txt 
                 182,405 
                 Aug. 23, 2004 
               
               
                 1961 
                 Table_1961_DLBCL_748_52245.txt 
                 182,432 
                 Aug. 23, 2004 
               
               
                 1962 
                 Table_1962_DLBCL_749_51826.txt 
                 182,374 
                 Aug. 23, 2004 
               
               
                 1963 
                 Table_1963_DLBCL_751_52278.txt 
                 182,393 
                 Aug. 23, 2004 
               
               
                 1964 
                 Table_1964_DL8CL_753_51824.txt 
                 182,281 
                 Aug. 23, 2004 
               
               
                 1965 
                 Table_1965_DLBCL_756_52098.txt 
                 182,335 
                 Aug. 23, 2004 
               
               
                 1966 
                 Table_1966_DLBCL_758_51831.txt 
                 182,344 
                 Aug. 23, 2004 
               
               
                 1967 
                 Table_1967_DLBCL_771_52983.txt 
                 182,405 
                 Aug. 23, 2004 
               
               
                 1968 
                 Table_1968_DLBCL_772_52984.txt 
                 182,523 
                 Aug. 23, 2004 
               
               
                 1969 
                 Table_1969_DLBCL_777_51827.txt 
                 182,369 
                 Aug. 23, 2004 
               
               
                 1970 
                 Table_1970_DLBCL_779_51822.txt 
                 182,217 
                 Aug. 23, 2004 
               
               
                 1971 
                 Table_1971_DLBCL_789_51821.txt 
                 182,375 
                 Aug. 23, 2004 
               
               
                 1972 
                 Table_1972_DLBCL_792_51820.txt 
                 182,462 
                 Aug. 23, 2004 
               
               
                 1773 
                 Table_1773_BL_2425_53383.txt 
                 182,690 
                 Aug. 25, 2004 
               
               
                 1774 
                 Table_1774_BL_2426_53384.txt 
                 182,593 
                 Aug. 25, 2004 
               
               
                 1775 
                 Table_1775_BL_2427_53385.txt 
                 182,514 
                 Aug. 25, 2004 
               
               
                 1776 
                 Table_1776_BL_2428_53386.txt 
                 182,479 
                 Aug. 25, 2004 
               
               
                 1777 
                 Table_1777_BL_2430_53387.txt 
                 182,369 
                 Aug. 25, 2004 
               
               
                 1778 
                 Table_1778_BL_2431_53388.txt 
                 182,235 
                 Aug. 25, 2004 
               
               
                 1779 
                 Table_1779_BL_2432_53389.txt 
                 182,564 
                 Aug. 25, 2004 
               
               
                 1780 
                 Table_1780_BL_2433_53390.txt 
                 182,477 
                 Aug. 25, 2004 
               
               
                 1781 
                 Table_1781_BL_2434_53391.txt 
                 182,590 
                 Aug. 25, 2004 
               
               
                 1782 
                 Table_1782_BL_2435_53392.txt 
                 182,553 
                 Aug. 25, 2004 
               
               
                 1783 
                 Table_1783_BL_2437_53393.txt 
                 182,354 
                 Aug. 26, 2004 
               
               
                 1784 
                 Table_1784_BL_2438_53394.txt 
                 182,345 
                 Aug. 26, 2004 
               
               
                 1785 
                 Table_1785_CD1N_1013_52338.txt 
                 182,526 
                 Aug. 25, 2004 
               
               
                 1786 
                 Table_1756_CD1N_1116_52359.txt 
                 182,611 
                 Aug. 26, 2004 
               
               
                 1787 
                 Table_1787_CD1N_1125_52360.txt 
                 182,605 
                 Aug. 26, 2004 
               
               
                 1788 
                 Table_1788_CD1N_1265_52792.txt 
                 182,740 
                 Aug. 26, 2004 
               
               
                 1789 
                 Table_1789_CD1N_2198_52794.txt 
                 182,606 
                 Aug. 26, 2004 
               
               
                 1790 
                 Table_1790_CD1N_2272_52793.txt 
                 182,532 
                 Aug. 26, 2004 
               
               
                 1791 
                 Table_1791_CD1N_930_52332.txt 
                 182,670 
                 Aug. 26, 2004 
               
               
                 1792 
                 Table_1792_CD1N_950_52333.txt 
                 182,682 
                 Aug. 26, 2004 
               
               
                 1793 
                 Table_1793_CD1N_985_52334.txt 
                 182,692 
                 Aug. 26, 2004 
               
               
                 1794 
                 Table_1794_CD1N_991_52335.txt 
                 182,668 
                 Aug. 26, 2004 
               
               
                 1795 
                 Table_1795_CLL_1275_52361.txt 
                 182,084 
                 Aug. 26, 2004 
               
               
                 1796 
                 Table_1796_CLL_1277_52363.txt 
                 182,150 
                 Aug. 26, 2004 
               
               
                 1797 
                 Table_1797_CLL_1278_52364.txt 
                 182,109 
                 Aug. 26, 2004 
               
               
                 1798 
                 Table_1798_CLL_1279_52365.txt 
                 182,039 
                 Aug. 26, 2004 
               
               
                 1799 
                 Table_1799_CLL_1283_52366.txt 
                 182,198 
                 Aug. 26, 2004 
               
               
                 1800 
                 Table_1800_CLL_1292_52367.txt 
                 182,099 
                 Aug. 26, 2004 
               
               
                 1801 
                 Table_1801_CLL_1293_52368.txt 
                 182,150 
                 Aug. 26, 2004 
               
               
                 1802 
                 Table_1802_CLL_1294_52369.txt 
                 182,208 
                 Aug. 26, 2004 
               
               
                 1803 
                 Table_1803_CLL_1297_52370.txt 
                 182,142 
                 Aug. 26, 2004 
               
               
                 1804 
                 Table_1804_CLL_1298_52371.txt 
                 182,102 
                 Aug. 26, 2004 
               
               
                 1805 
                 Table_1805_CLL_1302_52372.txt 
                 182,118 
                 Aug. 26, 2004 
               
               
                 1806 
                 Table_1806_CLL_1311_52373.txt 
                 182,138 
                 Aug. 26, 2004 
               
               
                 1807 
                 Table_1807_CLL_1344_51718.txt 
                 182,161 
                 Aug. 26, 2004 
               
               
                 1808 
                 Table_1808_CLL_1379_51719.txt 
                 182,375 
                 Aug. 26, 2004 
               
               
                 1809 
                 Table_1809_CLL_1381_51720.txt 
                 182,238 
                 Aug. 26, 2004 
               
               
                 1810 
                 Table_1810_CLL_1394_51721.txt 
                 182,185 
                 Aug. 26, 2004 
               
               
                 1811 
                 Table_1811_DLBCL_1000_51981.txt 
                 182,443 
                 Aug. 26, 2004 
               
               
                 1812 
                 Table_1812_DLBCL_1001_52158.txt 
                 182,528 
                 Aug. 26, 2004 
               
               
                 1813 
                 Table_1813_DLBCL_1002_51697.txt 
                 182,578 
                 Aug. 27, 2004 
               
               
                 1814 
                 Table_1814_DLBCL_1004_52159.txt 
                 182,456 
                 Aug. 27, 2004 
               
               
                 1815 
                 Table_1815_DLBCL_1005_52160.txt 
                 182,642 
                 Aug. 26, 2004 
               
               
                 1816 
                 Table_1816_DLBCL_1006_52161.txt 
                 182,480 
                 Aug. 26, 2004 
               
               
                 1817 
                 Table_1817_DLBCL_1007_52162.txt 
                 182,521 
                 Aug. 26, 2004 
               
               
                 1818 
                 Table_1818_DLBCL_1008_5a163.txt 
                 182,559 
                 Aug. 26, 2004 
               
               
                 1819 
                 Table_1819_DLBCL_1009_52971.txt 
                 182,393 
                 Aug. 26, 2004 
               
               
                 1820 
                 Table_1820_DLBCL_1018_52165.txt 
                 182,598 
                 Aug. 27, 2004 
               
               
                 1821 
                 Table_1821_DLBCL_1021_52166.txt 
                 182,432 
                 Aug. 27, 2004 
               
               
                 1822 
                 Table_1822_DLBCL_1023_52167.txt 
                 182,504 
                 Aug. 27, 2004 
               
               
                 1823 
                 Table_1823_DLBCL_1024_52168.txt 
                 182,695 
                 Aug. 27, 2004 
               
               
                 1824 
                 Table_1824_DLBCL_1025_52169.txt 
                 182,615 
                 Aug. 27, 2004 
               
               
                 1825 
                 Table_1825_DLBCL_1026_52170.txt 
                 182,575 
                 Aug. 27, 2004 
               
               
                 1826 
                 Table_1826_DLBCL_1027_52171.txt 
                 182,667 
                 Aug. 27, 2004 
               
               
                 1827 
                 Table_1827_DLBCL_1031_52172.txt 
                 182,494 
                 Aug. 27, 2004 
               
               
                 1828 
                 Table_1828_DLBCL_1034_52231.txt 
                 182,455 
                 Aug. 27, 2004 
               
               
                 1829 
                 Table_1829_DLBCL_1037_52200.txt 
                 182,455 
                 Aug. 30, 2004 
               
               
                 1830 
                 Table_1830_DLBCL_1038_52232.txt 
                 182,577 
                 Aug. 30, 2004 
               
               
                 1831 
                 Table_1831_DLBCL_1039_52233.txt 
                 182,501 
                 Aug. 30, 2004 
               
               
                 1832 
                 Table_1832_DLBCL_1041_52201.txt 
                 182,599 
                 Aug. 30, 2004 
               
               
                 1833 
                 Table_1833_DLBCL_1043_52202.txt 
                 182,598 
                 Aug. 30, 2004 
               
               
                 1834 
                 Table_1834_DLBCL_1045_52203.txt 
                 182,555 
                 Aug. 30, 2004 
               
               
                 1835 
                 Table_1835_DLBCL_1049_52204.txt 
                 182,569 
                 Aug. 30, 2004 
               
               
                 1836 
                 Table_1836_DLBCL_1051_52173.txt 
                 182,324 
                 Aug. 30, 2004 
               
               
                 1837 
                 Table_1837_DLBCL_1054_52174.txt 
                 182,590 
                 Aug. 30, 2004 
               
               
                 1838 
                 Table_1838_DLBCL_1055_52175.txt 
                 182,433 
                 Aug. 30, 2004 
               
               
                 1839 
                 Table_1838_DLBCL_1057_52176.txt 
                 182,524 
                 Aug. 30, 2004 
               
               
                 1840 
                 Table_1840_DLBCL_1058_52177.txt 
                 182,386 
                 Aug. 30, 2004 
               
               
                 1841 
                 Table_1841_DLBCL_1059_52178.txt 
                 182,651 
                 Aug. 30, 2004 
               
               
                 1842 
                 Table_1842_DLBCL_1060_52179.txt 
                 182,633 
                 Aug. 30, 2004 
               
               
                 1843 
                 Table_1843_DLBCL_1061_52180.txt 
                 182,530 
                 Aug. 30, 2004 
               
               
                 1844 
                 Table_1844_DLBCL_1990_52108.txt 
                 182,550 
                 Aug. 30, 2004 
               
               
                 1845 
                 Table_1845_DLBCL_1991_52109.txt 
                 182,503 
                 Aug. 30, 2004 
               
               
                 1846 
                 Table_1846_DLBCL_1994_52110.txt 
                 182,422 
                 Aug. 30, 2004 
               
               
                 1847 
                 Table_1847_DLBCL_2001_52111.txt 
                 182,439 
                 Aug. 30, 2004 
               
               
                 1848 
                 Table_1848_DLBCL_2017_52112.txt 
                 182,354 
                 Aug. 31, 2004 
               
               
                 1849 
                 Table_1849_DLBCL_2018_52113.txt 
                 182,479 
                 Aug. 31, 2004 
               
               
                 1850 
                 Table_1850_DLBCL_2095_52258.txt 
                 182,492 
                 Aug. 31, 2004 
               
               
                 1851 
                 Table_1851_DLBCL_304_52190.txt 
                 182,498 
                 Aug. 31, 2004 
               
               
                 1852 
                 Table_1852_DLBCL_305_52191.txt 
                 182,502 
                 Aug. 31, 2004 
               
               
                 1853 
                 Table_1853_DLBCL_306_52192.txt 
                 182,549 
                 Aug. 31, 2004 
               
               
                 1854 
                 Table_1854_DLBCL_309_52973.txt 
                 182,434 
                 Aug. 31, 2004 
               
               
                 1855 
                 Table_1855_DLBCL_310_52194.txt 
                 182,489 
                 Aug. 30, 2004 
               
               
                 1856 
                 Table_1856_DLBCL_412_52009.txt 
                 182,344 
                 Aug. 30, 2004 
               
               
                 1857 
                 Table_1857_DLBCL_413_52974.txt 
                 182,340 
                 Aug. 30, 2004 
               
               
                 1858 
                 Table_1858_DLBCL_415_51696.txt 
                 182,507 
                 Aug. 30, 2004 
               
               
                 1859 
                 Table_1859_DLBCL_421_52975.txt 
                 182,519 
                 Aug. 30, 2004 
               
               
                 1860 
                 Table_1860_DLBCL_424_51989.txt 
                 182,537 
                 Aug. 30, 2004 
               
               
                 1861 
                 Table_1861_DLBCL_428_51985.txt 
                 182,415 
                 Aug. 30, 2004 
               
               
                 1862 
                 Table_1862_DLBCL_432_52011.txt 
                 182,400 
                 Aug. 30, 2004 
               
               
                 1863 
                 Table_1863_DLBCL_433_52010.txt 
                 182,501 
                 Aug. 30, 2004 
               
               
                 1864 
                 Table_1864_DLBCL_434_51693.txt 
                 182,610 
                 Aug. 30, 2004 
               
               
                 1865 
                 Table_1865_DLBCL_438_51998.txt 
                 182,437 
                 Aug. 30, 2004 
               
               
                 1866 
                 Table_1866_DLBCL_439_52252.txt 
                 182,417 
                 Aug. 30, 2004 
               
               
                 1867 
                 Table_1867_DLBCL_446_52004.txt 
                 182,554 
                 Aug. 31, 2004 
               
               
                 1868 
                 Table_1868_DLBCL_449_51995.txt 
                 182,556 
                 Aug. 31, 2004 
               
               
                 1869 
                 Table_1869_DLBCL_452_52114.txt 
                 182,501 
                 Aug. 31, 2004 
               
               
                 1870 
                 Table_1870_DLBCL_458_51990.txt 
                 182,494 
                 Aug. 31, 2004 
               
               
                 1871 
                 Table_1871_DLBCL_459_51695.txt 
                 182,583 
                 Aug. 31, 2004 
               
               
                 1872 
                 Table_1872_DLBCL_460_51986.txt 
                 182,618 
                 Aug. 31, 2004 
               
               
                 1873 
                 Table_1873_DLBCL_462_51999.txt 
                 182,431 
                 Aug. 31, 2004 
               
               
                 1874 
                 Table_1874_DLBCL_470_52188.txt 
                 182,400 
                 Aug. 31, 2004 
               
               
                 1875 
                 Table_1875_DLBCL_477_52724.txt 
                 182,482 
                 Aug. 31, 2004 
               
               
                 1876 
                 Table_1876_DLBCL_479_52017.txt 
                 182,484 
                 Aug. 31, 2004 
               
               
                 1877 
                 Table_1877_DLBCL_481_51992.txt 
                 182,632 
                 Aug. 31, 2004 
               
               
                 1878 
                 Table_1878_DLBCL_482_52013.txt 
                 182,394 
                 Aug. 31, 2004 
               
               
                 1879 
                 Table_1879_DLBCL_491_51982.txt 
                 182,481 
                 Aug. 31, 2004 
               
               
                 1880 
                 Table_1880_DLBCL_492_51694.txt 
                 182,573 
                 Aug. 31, 2004 
               
               
                 1881 
                 Table_1881_DLBCL_517_52018.txt 
                 182,479 
                 Aug. 31, 2004 
               
               
                 1882 
                 Table_1882_DLBCL_523_52056.txt 
                 182,366 
                 Aug. 31, 2004 
               
               
                 1883 
                 Table_1883_DLBCL_524_51993.txt 
                 182,690 
                 Aug. 31, 2004 
               
               
                 1884 
                 Table_1884_DLBCL_528_52001.txt 
                 182,438 
                 Aug. 31, 2004 
               
               
                 1885 
                 Table_1885_DLBCL_529_52002.txt 
                 182,388 
                 Aug. 31, 2004 
               
               
                 1886 
                 Table_1886_DLBCL_533_52099.txt 
                 182,603 
                 Aug. 31, 2004 
               
               
                 1887 
                 Table_1887_DLBCL_537_52003.txt 
                 182,396 
                 Aug. 31, 2004 
               
               
                 1888 
                 Table_1888_DLBCL_538_51698.txt 
                 182,531 
                 Aug. 31, 2004 
               
               
                 1889 
                 Table_1889_DLBCL_541_52100.txt 
                 182,500 
                 Aug. 31, 2004 
               
               
                 1890 
                 Table_1890_DLBCL_543_52101.txt 
                 182,754 
                 Aug. 31, 2004 
               
               
                 1891 
                 Table_1891_DLBCL_544_52115.txt 
                 182,571 
                 Aug. 31, 2004 
               
               
                 1892 
                 Table_1892_DLBCL_545_52117.txt 
                 182,644 
                 Aug. 31, 2004 
               
               
                 1893 
                 Table_1893_DLBCL_547_52089.txt 
                 182,539 
                 Aug. 31, 2004 
               
               
                 1894 
                 Table_1894_DLBCL_549_52090.txt 
                 182,569 
                 Aug. 31, 2004 
               
               
                 1895 
                 Table_1895_DLBCL_550_51836.txt 
                 182,321 
                 Aug. 23, 2004 
               
               
                 1896 
                 Table_1896_DLBCL_553_52091.txt 
                 182,456 
                 Aug. 23, 2004 
               
               
                 1897 
                 Table_1897_DLBCL_565_52092.txt 
                 182,388 
                 Aug. 23, 2004 
               
               
                 1898 
                 Table_1898_DLBCL_572_52093.txt 
                 182,395 
                 Aug. 23, 2004 
               
               
                 1899 
                 Table_1899_DLBCL_577_52102.txt 
                 182,336 
                 Aug. 23, 2004 
               
               
                 1900 
                 Table_1900_DLBCL_615_52014.txt 
                 182,286 
                 Aug. 23, 2004 
               
               
                 1901 
                 Table_1901_DLBCL_616_52015.txt 
                 182,089 
                 Aug. 23, 2004 
               
               
                 1902 
                 Table_1902_DLBCL_617_52189.txt 
                 182,485 
                 Aug. 23, 2004 
               
               
                 1903 
                 Table_1903_DLBCL_618_52012.txt 
                 182,239 
                 Aug. 23, 2004 
               
               
                 1904 
                 Table_1904_DLBCL_619_52005.txt 
                 182,336 
                 Aug. 23, 2004 
               
               
                 1905 
                 Table_1905_DLBCL_623_51984.txt 
                 182,212 
                 Aug. 23, 2004 
               
               
                 1906 
                 Table_1906_DLBCL_625_52253.txt 
                 182,476 
                 Aug. 23, 2004 
               
               
                 1907 
                 Table_1907_DLBCL_626_52007.txt 
                 182,302 
                 Aug. 23, 2004 
               
               
                 1908 
                 Table_1908_DLBCL_627_52006.txt 
                 182,273 
                 Aug. 2$, 2004 
               
               
                 1909 
                 Table_1909_DLBCL_633_52150.txt 
                 182,449 
                 Aug. 23, 2004 
               
               
                 1910 
                 Table_1910_DLBCL_638_52151.txt 
                 182,493 
                 Aug. 23, 2004 
               
               
                 1911 
                 Table_1911_DLBCL_642_52254.txt 
                 182,293 
                 Aug. 23, 2004 
               
               
                 1912 
                 Table_1912_DLBCL_644_52116.txt 
                 182,430 
                 Aug. 23, 2004 
               
               
                 1913 
                 Table_1913_DLBCL_645_52118.txt 
                 182,332 
                 Aug. 23, 2004 
               
               
                 1914 
                 Table_1914_DLBCL_646_52119.txt 
                 182,252 
                 Aug. 23, 2004 
               
               
                 1915 
                 Table_1915_DLBCL_651_52121.txt 
                 182,380 
                 Aug. 23, 2004 
               
               
                 1916 
                 Table_1916_DLBCL_652_52120.txt 
                 182,395 
                 Aug. 23, 2004 
               
               
                 1917 
                 Table_1917_DLBCL_654_52016.txt 
                 182,268 
                 Aug. 23, 2004 
               
               
                 1918 
                 Table_1918_DLBCL_660_52057.txt 
                 182,197 
                 Aug. 23, 2004 
               
               
                 1919 
                 Table_1919_DLBCL_661_52058.txt 
                 182,346 
                 Aug. 23, 2004 
               
               
                 1920 
                 Table_1920_DLBCL_663_52071.txt 
                 182,356 
                 Aug. 23, 2004 
               
               
                 1921 
                 Table_1921_DLBCL_664_52072.txt 
                 182,385 
                 Aug. 23, 2004 
               
               
                 1922 
                 Table_1922_DLBCL_668_52073.txt 
                 182,322 
                 Aug. 23, 2004 
               
               
                 1973 
                 Table_1973_DLBCL_795_52156.txt 
                 182,448 
                 Aug. 23, 2004 
               
               
                 1974 
                 Table_1974_DLBCL_797_52103.txt 
                 182,220 
                 Aug. 23, 2004 
               
               
                 1975 
                 Table_1975_DLBCL_800_52337.txt 
                 182,289 
                 Aug. 23, 2004 
               
               
                 1976 
                 Table_1976_DLBCL_803_52163.txt 
                 182,306 
                 Aug. 23, 2004 
               
               
                 1977 
                 Table_1977_DLBCL_807_52104.txt 
                 182,252 
                 Aug. 23, 2004 
               
               
                 1978 
                 Table_1978_DLBCL_808_52126.txt 
                 182,358 
                 Aug. 23, 2004 
               
               
                 1979 
                 Table_1979_DLBCL_809_52105.txt 
                 182,334 
                 Aug. 23, 2004 
               
               
                 1980 
                 Table_1980_DLBCL_810_52106.txt 
                 182,272 
                 Aug. 23, 2004 
               
               
                 1981 
                 Table_1981_DLBCL_816_52985.txt 
                 182,117 
                 Aug. 23, 2004 
               
               
                 1982 
                 Table_1982_DLBCL_817_52986.txt 
                 182,236 
                 Aug. 23, 2004 
               
               
                 1983 
                 Table_1983_DLBCL_818_52184.txt 
                 182,423 
                 Aug. 23, 2004 
               
               
                 1984 
                 Table_1984_DLBCL_819_52987.txt 
                 182,345 
                 Aug. 23, 2004 
               
               
                 1985 
                 Table_1985_DLBCL_820_52988.txt 
                 182,366 
                 Aug. 23, 2004 
               
               
                 1986 
                 Table_1986_DLBCL_821_52339.txt 
                 182,490 
                 Aug. 23, 2004 
               
               
                 1987 
                 Table_1987_DLBCL_823_52989.txt 
                 182,102 
                 Aug. 23, 2004 
               
               
                 1988 
                 Table_1988_DLBCL_831_51996.txt 
                 182,390 
                 Aug. 23, 2004 
               
               
                 1989 
                 Table_1989_DLBCL_832_51997.txt 
                 182,459 
                 Aug. 23, 2004 
               
               
                 1990 
                 Table_1990_DLBCL_834_52186.txt 
                 182,214 
                 Aug. 23, 2004 
               
               
                 1991 
                 Table_1991_DLBCL_835_51988.txt 
                 182,362 
                 Aug. 23, 2004 
               
               
                 1992 
                 Table_1992_DLBCL_836_52000.txt 
                 182,322 
                 Aug. 23, 2004 
               
               
                 1993 
                 Table_1993_DLBCL_838_51987.txt 
                 182,402 
                 Aug. 23, 2004 
               
               
                 1994 
                 Table_1994_DLBCL_839_51991.txt 
                 182,377 
                 Aug. 23, 2004 
               
               
                 1995 
                 Table_1995_DLBCL_840_52990.txt 
                 182,527 
                 Aug. 23, 2004 
               
               
                 1996 
                 Table_1996_DLBCL_841_52087.txt 
                 182,353 
                 Aug. 23, 2004 
               
               
                 1997 
                 Table_1997_DLBCL_847_52187.txt 
                 182,422 
                 Aug. 23, 2004 
               
               
                 1998 
                 Table_1998_DLBCL_851_52991.txt 
                 182,280 
                 Aug. 23, 2004 
               
               
                 1999 
                 Table_1999_DLBCL_854_52088.txt 
                 182,372 
                 Aug. 23, 2004 
               
               
                 2000 
                 Table_2000_DLBCL_855_51837.txt 
                 182,472 
                 Aug. 23, 2004 
               
               
                 2001 
                 Table_2001_DLBCL_856_52992.txt 
                 182,213 
                 Aug. 23, 2004 
               
               
                 2002 
                 Table_2002_DLBCL_858_52993.txt 
                 182,472 
                 Aug. 23, 2004 
               
               
                 2003 
                 Table_2003_DLBCL_860_52195.txt 
                 182,229 
                 Aug. 23, 2004 
               
               
                 2004 
                 Table_2004_DLBCL_871_52196.txt 
                 182,241 
                 Aug. 23, 2004 
               
               
                 2005 
                 Table_2005_DLBCL_872_51700.txt 
                 182,279 
                 Aug. 23, 2004 
               
               
                 2006 
                 Table_2005_DLBCL_874_52107.txt 
                 182,412 
                 Aug. 23, 2004 
               
               
                 2007 
                 Table_2007_ULBOL_875_52246.txt 
                 182,286 
                 Aug. 23, 2004 
               
               
                 2008 
                 Table_2008_DLBCL_912_52197.txt 
                 182,328 
                 Aug. 23, 2004 
               
               
                 2009 
                 Table_2009_DLBCL_995_52198.txt 
                 182,356 
                 Aug. 23, 2004 
               
               
                 2010 
                 Table_2010_DLBCL_996_52199.txt 
                 182,251 
                 Aug. 23, 2004 
               
               
                 2011 
                 Table_2011_DLBCL_998_52157.txt 
                 182,354 
                 Aug. 23, 2004 
               
               
                 2012 
                 Table_2012_FH_2043_52774.txt 
                 182,536 
                 Aug. 23, 2004 
               
               
                 2013 
                 Table_2013_FH_2045_52775.txt 
                 182,609 
                 Aug. 23, 2004 
               
               
                 2014 
                 Table_2014_FH_2047_52776.txt 
                 182,602 
                 Aug. 23, 2004 
               
               
                 2015 
                 Table_2015_FH_2120_52777.txt 
                 182,548 
                 Aug. 23, 2004 
               
               
                 2016 
                 Table_2016_FH_2123_52778.txt 
                 182,516 
                 Aug. 23, 2004 
               
               
                 2017 
                 Table_2017_FH_2124_52779.txt 
                 182,535 
                 Aug. 23, 2004 
               
               
                 2018 
                 Table_2018_FH_2138_52780.txt 
                 182,370 
                 Aug. 23, 2004 
               
               
                 2019 
                 Table_2019_FH_2139_52781.txt 
                 182,510 
                 Aug. 23, 2004 
               
               
                 2020 
                 Table_2020_FH_2140_52782.txt 
                 182,561 
                 Aug. 23, 2004 
               
               
                 2021 
                 Table_2021_FH_2141_52783.txt 
                 182,575 
                 Aug. 23, 2004 
               
               
                 2022 
                 Table_2022_FH_2142_52784.txt 
                 182,552 
                 Aug. 23, 2004 
               
               
                 2023 
                 Table_2023_FH_2143_52785.txt 
                 182,502 
                 Aug. 23, 2004 
               
               
                 2024 
                 Table_2024_FH_2159_52786.txt 
                 182,442 
                 Aug. 23, 2004 
               
               
                 2025 
                 Table_2025_FH_2160_52787.txt 
                 182,430 
                 Aug. 23, 2004 
               
               
                 2026 
                 Table_2026_FH_2161_52788.txt 
                 182,442 
                 Aug. 23, 2004 
               
               
                 2027 
                 Table_2027_FH_2162_52789.txt 
                 182,507 
                 Aug. 23, 2004 
               
               
                 2028 
                 Table_2028_FH_2164_52790.txt 
                 182,524 
                 Aug. 23, 2004 
               
               
                 2029 
                 Table_2029_FH_2167_52791.txt 
                 182,593 
                 Aug. 23, 2004 
               
               
                 2036 
                 Table_2030_FL_1073_52458.txt 
                 182,551 
                 Aug. 23, 2004 
               
               
                 2031 
                 Table_2031_FL_1074_52459.txt 
                 182,424 
                 Aug. 23, 2004 
               
               
                 2032 
                 Table_2032_FL_1075_52460.txt 
                 182,490 
                 Aug. 23, 2004 
               
               
                 2033 
                 Table_2033_FL_1076_52461.txt 
                 182,391 
                 Aug. 23, 2004 
               
               
                 2034 
                 Table_2034_FL_1077_52463.txt 
                 182,504 
                 Aug. 23, 2004 
               
               
                 2035 
                 Table_2035_FL_1078_52464.txt 
                 182,477 
                 Aug. 23, 2004 
               
               
                 2036 
                 Table_2036_FL_1080_52465.txt 
                 182,534 
                 Aug. 23, 2004 
               
               
                 2037 
                 Table_2037_FL_1081_52660.txt 
                 182,448 
                 Aug. 23, 2004 
               
               
                 2038 
                 Table_2038_FL_1083_52466.txt 
                 182,566 
                 Aug. 23, 2004 
               
               
                 2039 
                 Table_2039_FL_1085_52467.txt 
                 182,520 
                 Aug. 23, 2004 
               
               
                 2040 
                 Table_2040_FL_1086_52468.txt 
                 182,529 
                 Aug. 23, 2004 
               
               
                 2041 
                 Table_2041_FL_1087_52469.txt 
                 182,476 
                 Aug. 23, 2004 
               
               
                 2042 
                 Table_2042_FL_1088_52470.txt 
                 182,466 
                 Aug. 23, 2004 
               
               
                 2043 
                 Table_2043_FL_1089_52471.txt 
                 182,361 
                 Aug. 23, 2004 
               
               
                 2044 
                 Table_2044_FL_1090_52472.txt 
                 182,477 
                 Aug. 23, 2004 
               
               
                 2045 
                 Table_2045_FL_1097_52473.txt 
                 182,532 
                 Aug. 23, 2004 
               
               
                 2046 
                 Table_2046_FL_1098_52474.txt 
                 182,589 
                 Aug. 23, 2004 
               
               
                 2047 
                 Table_2047_FL_1099_52475.txt 
                 182,513 
                 Aug. 23, 2004 
               
               
                 2048 
                 Table_2048_FL_1102_52648.txt 
                 182,505 
                 Aug. 23, 2004 
               
               
                 2049 
                 Table_2049_FL_1104_52649.txt 
                 182,423 
                 Aug. 23, 2004 
               
               
                 2050 
                 Table_2050_FL_1106_52476.txt 
                 182,475 
                 Aug. 23, 2004 
               
               
                 2051 
                 Table_2051_FL_1107_52650.txt 
                 182,528 
                 Aug. 23, 2004 
               
               
                 2052 
                 Table_2052_FL_1183_52651.txt 
                 182,441 
                 Aug. 23, 2004 
               
               
                 2053 
                 Table_2053_FL_1184_52652.txt 
                 182,560 
                 Aug. 23, 2004 
               
               
                 2054 
                 Table_2054_FL_1185_52653.txt 
                 182,459 
                 Aug. 23, 2004 
               
               
                 2055 
                 Table_2055_FL_1186_52654.txt 
                 182,532 
                 Aug. 23, 2004 
               
               
                 2056 
                 Table_2056_FL_1416_52655.txt 
                 182,489 
                 Aug. 23, 2004 
               
               
                 2057 
                 Table_2057_FL_1417_52656.txt 
                 182,381 
                 Aug. 23, 2004 
               
               
                 2058 
                 Table_2058_FL_1418_52657.txt 
                 182,418 
                 Aug. 23, 2004 
               
               
                 2059 
                 Table_2059_FL_1419_52658.txt 
                 182,527 
                 Aug. 23, 2004 
               
               
                 2060 
                 Table_2060_FL_1422_52659.txt 
                 182,462 
                 Aug. 23, 2004 
               
               
                 2061 
                 Table_2061_FL_1425_51703.txt 
                 182,392 
                 Aug. 23, 2004 
               
               
                 2062 
                 Table_2062_FL_1426_51702.txt 
                 182,416 
                 Aug. 23, 2004 
               
               
                 2063 
                 Table_2063_FL_1427_52997.txt 
                 182,307 
                 Aug. 23, 2004 
               
               
                 2064 
                 Table_2064_FL_1428_51705.txt 
                 182,460 
                 Aug. 23, 2004 
               
               
                 2065 
                 Table_2065_FL_1429_52661.txt 
                 182,411 
                 Aug. 23, 2004 
               
               
                 2066 
                 Table_2066_FL_1432_52999.txt 
                 182,463 
                 Aug. 23, 2004 
               
               
                 2067 
                 Table_2067_FL_1434_52662.txt 
                 182,762 
                 Aug. 23, 2004 
               
               
                 2068 
                 Table_2068_FL_1436_52663.txt 
                 182,426 
                 Aug. 23, 2004 
               
               
                 2069 
                 Table_2069_FL_1440_52664.txt 
                 182,383 
                 Aug. 23, 2004 
               
               
                 2070 
                 Table_2070_FL_1445_52665.txt 
                 182,413 
                 Aug. 23, 2004 
               
               
                 2071 
                 Table_2071_FL_1450_52666.txt 
                 182,480 
                 Aug. 23, 2004 
               
               
                 2072 
                 Table_2072_FL_1472_52667.txt 
                 182,367 
                 Aug. 23, 2004 
               
               
                 2073 
                 Table_2073_FL_1473_53000.txt 
                 182,558 
                 Aug. 23, 2004 
               
               
                 2074 
                 Table_2074_FL_1474_53001.txt 
                 182,648 
                 Aug. 23, 2004 
               
               
                 2075 
                 Table_2075_FL_1476_52668.txt 
                 182,438 
                 Aug. 23, 2004 
               
               
                 2076 
                 Table_2076_FL_1477_52669.txt 
                 182,425 
                 Aug. 23, 2004 
               
               
                 2077 
                 Table_2077_FL_1478_52670.txt 
                 182,377 
                 Aug. 23, 2004 
               
               
                 2078 
                 Table_2078_FL_1479_52671.txt 
                 182,411 
                 Aug. 23, 2004 
               
               
                 2079 
                 Table_2079_FL_1480_52672.txt 
                 182,428 
                 Aug. 23, 2004 
               
               
                 2080 
                 Table_2080_FL_1579_52673.txt 
                 182,439 
                 Aug. 23, 2004 
               
               
                 2081 
                 Tabl8_2081_FL_1580_52674.txt 
                 182,552 
                 Aug. 23, 2004 
               
               
                 2082 
                 Table_2082_FL_1581_52675.txt 
                 182,497 
                 Aug. 23, 2004 
               
               
                 2083 
                 Table_2083_FL_1552_52676.txt 
                 182,370 
                 Aug. 23, 2004 
               
               
                 2084 
                 Table_2084_FL_1583_52677.txt 
                 182,535 
                 Aug. 23, 2004 
               
               
                 2085 
                 Table_2085_FL_1584_52678.txt 
                 182,524 
                 Aug. 23, 2004 
               
               
                 2086 
                 Table_2086_FL_1585_52726.txt 
                 182,443 
                 Aug. 23, 2004 
               
               
                 2087 
                 Table_2087_FL_1586_52679.txt 
                 182,465 
                 Aug. 23, 2004 
               
               
                 2088 
                 Table_2088_FL_1588_52680.txt 
                 182,490 
                 Aug. 23, 2004 
               
               
                 2089 
                 Table_2089_FL_1589_52681.txt 
                 182,477 
                 Aug. 23, 2004 
               
               
                 2090 
                 Table_2090_FL_1591_52682.txt 
                 182,513 
                 Aug. 23, 2004 
               
               
                 2091 
                 Table_2091_FL_1594_52683.txt 
                 182,498 
                 Aug. 23, 2004 
               
               
                 2092 
                 Table_2092_FL_1595_52684.txt 
                 182,547 
                 Aug. 23, 2004 
               
               
                 2093 
                 Table_2093_FL_1598_52685.txt 
                 182,415 
                 Aug. 23, 2004 
               
               
                 2094 
                 Table_2004_FL_1599_52686.txt 
                 182,531 
                 Aug. 23, 2004 
               
               
                 2095 
                 Table_2095_FL_1603_52687.txt 
                 182,544 
                 Aug. 23, 2004 
               
               
                 2090 
                 Table_2096_FL_1604_52688.txt 
                 182,394 
                 Aug. 23, 2004 
               
               
                 2097 
                 Table_2097_FL_1606_52689.txt 
                 182,440 
                 Aug. 23, 2004 
               
               
                 2098 
                 Table_2098_FL_1607_52690.txt 
                 182,527 
                 Aug. 23, 2004 
               
               
                 2099 
                 Table_2099_FL_1608_52691.txt 
                 182,440 
                 Aug. 23, 2004 
               
               
                 2100 
                 Table_2100_FL_1610_52692.txt 
                 182,452 
                 Aug. 23, 2004 
               
               
                 2101 
                 Table_2101_FL_1611_52693.txt 
                 182,488 
                 Aug. 23, 2004 
               
               
                 2102 
                 Table_2102_FL_1616_52694.txt 
                 182,438 
                 Aug. 23, 2004 
               
               
                 2103 
                 Table_2103_FL_1617_52695.txt 
                 182,496 
                 Aug. 23, 2004 
               
               
                 2104 
                 Table_2104_FL_1619_52696.txt 
                 182,544 
                 Aug. 23, 2004 
               
               
                 2105 
                 Table_2105_FL_1622_52388.txt 
                 182,452 
                 Aug. 23, 2004 
               
               
                 2106 
                 Table_2106_FL_1623_52389.txt 
                 182,521 
                 Aug. 23, 2004 
               
               
                 2107 
                 Table_2107_FL_1624_52390.txt 
                 182,474 
                 Aug. 23, 2004 
               
               
                 2108 
                 Table_2108_FL_1625_52391.txt 
                 182,364 
                 Aug. 23, 2004 
               
               
                 2109 
                 Table_2109_FL_1626_52392.txt 
                 182,350 
                 Aug. 23, 2004 
               
               
                 2110 
                 Table_2110_FL_1627_52393.txt 
                 182,558 
                 Aug. 23, 2004 
               
               
                 2111 
                 Table_2111_FL_1628_52394.txt 
                 182,561 
                 Aug. 23, 2004 
               
               
                 2112 
                 Table_2112_FL_1637_52395.txt 
                 182,562 
                 Aug. 23, 2004 
               
               
                 2113 
                 Table_2113_FL_1638_53003.txt 
                 182,388 
                 Aug. 23, 2004 
               
               
                 2114 
                 Table_2114_FL_1639_52396.txt 
                 182,466 
                 Aug. 23, 2004 
               
               
                 2115 
                 Table_2115_FL_1643_52397.txt 
                 182,502 
                 Aug. 23, 2004 
               
               
                 2116 
                 Table_2116_FL_1644_52398.txt 
                 182,453 
                 Aug. 23, 2004 
               
               
                 2117 
                 Table_2117_FL_1645_52399.txt 
                 182,430 
                 Aug. 23, 2004 
               
               
                 2118 
                 Table_2118_FL_1646_52400.txt 
                 182,457 
                 Aug. 23, 2004 
               
               
                 2119 
                 Table_2119_FL_1647_52401.txt 
                 182,386 
                 Aug. 23, 2004 
               
               
                 2120 
                 Table_2120_FL_1648_52402.txt 
                 182,358 
                 Aug. 23, 2004 
               
               
                 2121 
                 Table_2121_FL_1652_52403.txt 
                 182,506 
                 Aug. 23, 2004 
               
               
                 2122 
                 Table_2122_FL_1654_53004.txt 
                 182,392 
                 Aug. 23, 2004 
               
               
                 2123 
                 Table_2123_FL_1655_52404.txt 
                 182,479 
                 Aug. 23, 2004 
               
               
                 2124 
                 Table_2124_FL_1656_52405.txt 
                 182,364 
                 Aug. 23, 2004 
               
               
                 2125 
                 Table_2125_FL_1657_52406.txt 
                 182,439 
                 Aug. 23, 2004 
               
               
                 2126 
                 Table_2126_FL_1660_52407.txt 
                 182,458 
                 Aug. 23, 2004 
               
               
                 2127 
                 Table_2127_FL_1661_52408.txt 
                 182,602 
                 Aug. 23, 2004 
               
               
                 2128 
                 Table_2128_FL_1662_52409.txt 
                 182,469 
                 Aug. 23, 2004 
               
               
                 2129 
                 Table_2129_FL_1664_52410.txt 
                 182,507 
                 Aug. 23, 2004 
               
               
                 2130 
                 Table_2130_FL_1669_52411.txt 
                 182,451 
                 Aug. 23, 2004 
               
               
                 2131 
                 Table_2131_FL_1670_52412.txt 
                 182,471 
                 Aug. 23, 2004 
               
               
                 2132 
                 Table_2132_FL_1675_52413.txt 
                 182,442 
                 Aug. 23, 2004 
               
               
                 2133 
                 Table_2133_FL_1681_52421.txt 
                 182,476 
                 Aug. 23, 2004 
               
               
                 2134 
                 Table_2134_FL_1683_52422.txt 
                 182,531 
                 Aug. 23, 2004 
               
               
                 2135 
                 Table_2135_FL_1684_52423.txt 
                 182,455 
                 Aug. 23, 2004 
               
               
                 2136 
                 Table_2136_FL_1716_52414.txt 
                 182,416 
                 Aug. 23, 2004 
               
               
                 2137 
                 Table_2137_FL_1717_52415.txt 
                 182,526 
                 Aug. 23, 2004 
               
               
                 2138 
                 Table_2138_FL_1718_53006.txt 
                 182,411 
                 Aug. 23, 2004 
               
               
                 2139 
                 Table_2139_FL_1719_52416.txt 
                 182,449 
                 Aug. 23, 2004 
               
               
                 2140 
                 Table_2140_FL_1720_53025.txt 
                 182,424 
                 Aug. 23, 2004 
               
               
                 2141 
                 Table_2141_FL_1729_52417.txt 
                 182,495 
                 Aug. 23, 2004 
               
               
                 2142 
                 Table_2142_FL_1732_52418.txt 
                 182,340 
                 Aug. 23, 2004 
               
               
                 2143 
                 Table_2143_FL_1735_52419.txt 
                 182,212 
                 Aug. 23, 2004 
               
               
                 2144 
                 Table_2144_FL_1761_52424.txt 
                 182,512 
                 Aug. 23, 2004 
               
               
                 2145 
                 Table_2145_FL_1764_52425.txt 
                 182,533 
                 Aug. 23, 2004 
               
               
                 2146 
                 Table_2146_FL_1768_52426.txt 
                 182,520 
                 Aug. 23, 2004 
               
               
                 2147 
                 Table_2147_FL_1771_52427.txt 
                 182,487 
                 Aug. 23, 2004 
               
               
                 2148 
                 Table_2148_FL_1772_52428.txt 
                 182,547 
                 Aug. 23, 2004 
               
               
                 2149 
                 Table_2149_FL_1788_52429.txt 
                 182,481 
                 Aug. 23, 2004 
               
               
                 2150 
                 Table_2150_FL_1790_53008.txt 
                 182,535 
                 Aug. 23, 2004 
               
               
                 2151 
                 Table_2151_FL_1792_52431.txt 
                 182,458 
                 Aug. 23, 2004 
               
               
                 2152 
                 Table_2152_FL_1795_52432.txt 
                 182,548 
                 Aug. 23, 2004 
               
               
                 2153 
                 Table_2153_FL_1797_52433.txt 
                 182,519 
                 Aug. 23, 2004 
               
               
                 2154 
                 Table_2154_FL_1799_52434.txt 
                 182,430 
                 Aug. 23, 2004 
               
               
                 2155 
                 Table_2155_FL_1810_52435.txt 
                 182,362 
                 Aug. 23, 2004 
               
               
                 2456 
                 Table_2156_FL_1811_52436.txt 
                 182,501 
                 Aug. 23, 2004 
               
               
                 2157 
                 Table_2157_FL_1825_52437.txt 
                 182,460 
                 Aug. 23, 2004 
               
               
                 2158 
                 Table_2158_FL_1827_52438.txt 
                 182,528 
                 Aug. 23, 2004 
               
               
                 2159 
                 Table_2159_FL_1828_52439.txt 
                 182,506 
                 Aug. 23, 2004 
               
               
                 2160 
                 Table_2160_FL_1829_52440.txt 
                 182,533 
                 Aug. 23, 2004 
               
               
                 2161 
                 Table_2161_FL_1830_52441.txt 
                 182,448 
                 Aug. 23, 2004 
               
               
                 2162 
                 Table_2162_FL_1833_52442.txt 
                 182,523 
                 Aug. 23, 2004 
               
               
                 2163 
                 Table_2163_FL_1834_52443.txt 
                 182,477 
                 Aug. 23, 2004 
               
               
                 2164 
                 Table_2164_FL_1835_52444.txt 
                 182,469 
                 Aug. 23, 2004 
               
               
                 2165 
                 Table_2165_FL_1836_52445.txt 
                 182,504 
                 Aug. 23, 2004 
               
               
                 2166 
                 Table_2166_FL_1837_52446.txt 
                 182,453 
                 Aug. 23, 2004 
               
               
                 2167 
                 Table_2167_FL_1838_52447.txt 
                 182,465 
                 Aug. 23, 2004 
               
               
                 2168 
                 Table_2168_FL_1839_52448.txt 
                 182,343 
                 Aug. 23, 2004 
               
               
                 2169 
                 Table_2169_FL_1841_52449.txt 
                 182,524 
                 Aug. 23, 2004 
               
               
                 2170 
                 Table_2170_FL_1842_52450.txt 
                 182,510 
                 Aug. 23, 2004 
               
               
                 2171 
                 Table_2171_FL_1844_52451.txt 
                 182,456 
                 Aug. 23, 2004 
               
               
                 2172 
                 Table_2172_FL_1845_52452.txt 
                 182,582 
                 Aug. 23, 2004 
               
               
                 2173 
                 Table_2173_FL_1846_52477.txt 
                 182,514 
                 Aug. 23, 2004 
               
               
                 2174 
                 Table_2174_FL_1848_52478.txt 
                 182,510 
                 Aug. 23, 2004 
               
               
                 2175 
                 Table_2175_FL_1850_52479.txt 
                 182,504 
                 Aug. 23, 2004 
               
               
                 2176 
                 Table_2176_FL_1851_52480.txt 
                 182,536 
                 Aug. 23, 2004 
               
               
                 2177 
                 Table_2177_FL_1853_52481.txt 
                 182,501 
                 Aug. 23, 2004 
               
               
                 2178 
                 Table_2178_FL_1854_52482.txt 
                 182,554 
                 Aug. 23, 2004 
               
               
                 2179 
                 Table_2179_FL_1855_52483.txt 
                 182,515 
                 Aug. 23, 2004 
               
               
                 2180 
                 Table_2180_FL_1857_52484.txt 
                 182,644 
                 Aug. 23, 2004 
               
               
                 2181 
                 Table_2181_FL_1861_52453.txt 
                 182,539 
                 Aug. 23, 2004 
               
               
                 2182 
                 Table_2182_FL_1862_52454.txt 
                 182,489 
                 Aug. 23, 2004 
               
               
                 2183 
                 Table_2183_FL_1863_52455.txt 
                 182,508 
                 Aug. 23, 2004 
               
               
                 2184 
                 Table_2184_FL_1864_52456.txt 
                 182,617 
                 Aug. 23, 2004 
               
               
                 2185 
                 Table_2185_FL_1866_52457.txt 
                 182,516 
                 Aug. 23, 2004 
               
               
                 2186 
                 Table_2186_FL_1870_52697.txt 
                 182,562 
                 Aug. 23, 2004 
               
               
                 2187 
                 Table_2187_FL_1873_52698.txt 
                 182,436 
                 Aug. 23, 2004 
               
               
                 2188 
                 Table_2188_FL_1874_52699.txt 
                 182,463 
                 Aug. 23, 2004 
               
               
                 2189 
                 Table_2189_FL_1876_52700.txt 
                 182,466 
                 Aug. 23, 2004 
               
               
                 2190 
                 Table_2190_FL_1879_52701.txt 
                 182,465 
                 Aug. 23, 2004 
               
               
                 2191 
                 Table_2191_FL_1880_52702.txt 
                 182,458 
                 Aug. 23, 2004 
               
               
                 2192 
                 Table_2192_FL_1882_52704.txt 
                 182,512 
                 Aug. 23, 2004 
               
               
                 2193 
                 Table_2193_FL_1884_52705.txt 
                 182,489 
                 Aug. 23, 2004 
               
               
                 2194 
                 Table_2194_FL_1885_52706.txt 
                 182,507 
                 Aug. 23, 2004 
               
               
                 2195 
                 Table_2195_FL_1887_52707.txt 
                 182,481 
                 Aug. 23, 2004 
               
               
                 2196 
                 Table_2196_FL_1888_52708.txt 
                 182,550 
                 Aug. 23, 2004 
               
               
                 2197 
                 Table_2197_FL_1890_52709.txt 
                 182,428 
                 Aug. 23, 2004 
               
               
                 2198 
                 Table_2198_FL_1894_52710.txt 
                 182,442 
                 Aug. 23, 2004 
               
               
                 2199 
                 Table_2199_FL_1896_52711.txt 
                 182,482 
                 Aug. 23, 2004 
               
               
                 2200 
                 Table_2200_FL_1897_52756.txt 
                 182,367 
                 Aug. 23, 2004 
               
               
                 2201 
                 Table_2201_FL_1898_52757.txt 
                 182,315 
                 Aug. 23, 2004 
               
               
                 2202 
                 Table_2202_FL_1900_52712.txt 
                 182,352 
                 Aug. 23, 2004 
               
               
                 2203 
                 Table_2203_FL_1903_52713.txt 
                 182,354 
                 Aug. 23, 2004 
               
               
                 2204 
                 Table_2204_FL_1904_52714.txt 
                 182,421 
                 Aug. 23, 2004 
               
               
                 2205 
                 Table_2205_FL_1905_52715.txt 
                 182,450 
                 Aug. 23, 2004 
               
               
                 2206 
                 Table_2206_FL_1906_53010.txt 
                 182,295 
                 Aug. 23, 2004 
               
               
                 2207 
                 Table_2207_FL_1907_52717.txt 
                 182,268 
                 Aug. 23, 2004 
               
               
                 2208 
                 Table_2208_FL_1910_52718.txt 
                 182,425 
                 Aug. 23, 2004 
               
               
                 2209 
                 Table_2209_FL_1912_52719.txt 
                 182,519 
                 Aug. 23, 2004 
               
               
                 2210 
                 Table_2210_FL_1913_52720.txt 
                 182,464 
                 Aug. 23, 2004 
               
               
                 2211 
                 Table_2211_FL_1916_52721.txt 
                 182,418 
                 Aug. 23, 2004 
               
               
                 2212 
                 Table_2212_FL_1918_52722.txt 
                 182,529 
                 Aug. 23, 2004 
               
               
                 2213 
                 Table_2213_FL_1919_52723.txt 
                 182,388 
                 Aug. 23, 2004 
               
               
                 2214 
                 Table_2214_FL_735_52462.txt 
                 182,452 
                 Aug. 23, 2004 
               
               
                 2215 
                 Table_2215_FL_738_52642.txt 
                 182,363 
                 Aug. 23, 2004 
               
               
                 2216 
                 Table_2216_FL_739_52643.txt 
                 182,462 
                 Aug. 23, 2004 
               
               
                 2217 
                 Table_2217_FL_878_52644.txt 
                 182,344 
                 Aug. 23, 2004 
               
               
                 2218 
                 Table_2218_FL_879_52645.txt 
                 182,472 
                 Aug. 23, 2004 
               
               
                 2219 
                 Table_2219_FL_886_52646.txt 
                 182,483 
                 Aug. 23, 2004 
               
               
                 2220 
                 Table_2220_FL_888_52647.txt 
                 182,373 
                 Aug. 23, 2004 
               
               
                 2221 
                 Table_2221_GMALT_2021_52795.txt 
                 182,498 
                 Aug. 23, 2004 
               
               
                 2222 
                 Table_2222_GMALT_2041_52796.txt 
                 182,517 
                 Aug. 23, 2004 
               
               
                 2223 
                 Table_2223_GMALT_2065_52797.txt 
                 182,535 
                 Aug. 23, 2004 
               
               
                 2224 
                 Table_2224_GMALT_2067_52798.txt 
                 182,459 
                 Aug. 23, 2004 
               
               
                 2225 
                 Table_2225_GMALT_2070_52799.txt 
                 182,458 
                 Aug. 23, 2004 
               
               
                 2226 
                 Table_2226_GMALT_2110_52800.txt 
                 182,534 
                 Aug. 23, 2004 
               
               
                 2227 
                 Table_2227_GMALT_2111_52801.txt 
                 182,432 
                 Aug. 23, 2004 
               
               
                 2228 
                 Table_2228_GMALT_2112_52802.txt 
                 182,478 
                 Aug. 23, 2004 
               
               
                 2229 
                 Table_2229_GMALT_2270_52803.txt 
                 182,595 
                 Aug. 23, 2004 
               
               
                 2230 
                 Table_2230_LBL_2185_53023.txt 
                 182,457 
                 Aug. 23, 2004 
               
               
                 2231 
                 Table_2231_LBL_2186_52823.txt 
                 182,329 
                 Aug. 23, 2004 
               
               
                 2232 
                 Table_2232_LBL_2249_52824.txt 
                 182,381 
                 Aug. 23, 2004 
               
               
                 2233 
                 Table_2233_LPC_2224_52842.txt 
                 182,646 
                 Aug. 23, 2004 
               
               
                 2234 
                 Table_2234_LPC_2232_52843.txt 
                 182,608 
                 Aug. 23, 2004 
               
               
                 2235 
                 Table_2235_LPC_2261_52821.txt 
                 182,504 
                 Aug. 23, 2004 
               
               
                 2236 
                 Table_2236_LPC_2262_53542.txt 
                 182,616 
                 Aug. 23, 2004 
               
               
                 2237 
                 Table_2237_LPC_2263_52844.txt 
                 182,430 
                 Aug. 23, 2004 
               
               
                 2238 
                 Table_2238_LPC_2265_52845.txt 
                 182,451 
                 Aug. 23, 2004 
               
               
                 2239 
                 Table_2239_LPC_2410_53371.txt 
                 182,412 
                 Aug. 23, 2004 
               
               
                 2240 
                 Table_2240_LPC_2411_53372.txt 
                 182,521 
                 Aug. 23, 2004 
               
               
                 2241 
                 Table_2241_LPC_2412_53373.txt 
                 182,573 
                 Aug. 23, 2004 
               
               
                 2242 
                 Table_2242_LPC_2413_53374.txt 
                 182,501 
                 Aug. 23, 2004 
               
               
                 2243 
                 Table_2243_LPC_2414_53375.txt 
                 182,489 
                 Aug. 23, 2004 
               
               
                 2244 
                 Table_2244_MALT_2178_52827.txt 
                 182,515 
                 Aug. 23, 2004 
               
               
                 2245 
                 Table_2245_MALT_2181_52828.txt 
                 182,440 
                 Aug. 23, 2004 
               
               
                 2246 
                 Table_2246_MALT_2182_52829.txt 
                 182,507 
                 Aug. 23, 2004 
               
               
                 2247 
                 Table_2247_MALT_2183_52830.txt 
                 182,467 
                 Aug. 23, 2004 
               
               
                 2248 
                 Table_2248_MALT_2184_52831.txt 
                 182,543 
                 Aug. 23, 2004 
               
               
                 2249 
                 Table_2249_MALT_2202_52833.txt 
                 182,668 
                 Aug. 23, 2004 
               
               
                 2250 
                 Table_2250_MALT_2211_52836.txt 
                 182,623 
                 Aug. 23, 2004 
               
               
                 2251 
                 Table_2251_MALT_2243_52832.txt 
                 182,505 
                 Aug. 23, 2004 
               
               
                 2252 
                 Table_2252_MCL_1012_51716.txt 
                 182,396 
                 Aug. 23, 2004 
               
               
                 2253 
                 Table_2253_MCL_1091_52328.txt 
                 182,428 
                 Aug. 23, 2004 
               
               
                 2254 
                 Table_2254_MCL_1114_52329.txt 
                 182,400 
                 Aug. 23, 2004 
               
               
                 2255 
                 Table_2255_MCL_1128_51717.txt 
                 182,335 
                 Aug. 23, 2004 
               
               
                 2256 
                 Table_2256_MCL_1150_51714.txt 
                 182,428 
                 Aug. 23, 2004 
               
               
                 2257 
                 Table_2257_MCL_1162_51715.txt 
                 182,412 
                 Aug. 23, 2004 
               
               
                 2258 
                 Table_2258_MCL_1166_52330.txt 
                 182,469 
                 Aug. 23, 2004 
               
               
                 2259 
                 Table_2259_MCL_1194_52331.txt 
                 181,991 
                 Aug. 23, 2004 
               
               
                 2260 
                 Table_2260_MCL_885_53011.txt 
                 182,459 
                 Aug. 23, 2004 
               
               
                 2261 
                 Table_2261_MCL_918_52316.txt 
                 182,550 
                 Aug. 23, 2004 
               
               
                 2262 
                 Table_2262_MCL_924_52318.txt 
                 182,557 
                 Aug. 23, 2004 
               
               
                 2263 
                 Table_2263_MCL_925_52317.txt 
                 182,463 
                 Aug. 23, 2004 
               
               
                 2264 
                 Table_2264_MCL_926_52319.txt 
                 182,485 
                 Aug. 23, 2004 
               
               
                 2265 
                 Table_2265_MCL_936_52320.txt 
                 182,582 
                 Aug. 23, 2004 
               
               
                 2266 
                 Table_2266_MCL_939_52321.txt 
                 182,610 
                 Aug. 23, 2004 
               
               
                 2267 
                 Table_2267_MCL_953_52322.txt 
                 182,492 
                 Aug. 23, 2004 
               
               
                 2268 
                 Table_2268_MCL_956_52323.txt 
                 182,482 
                 Aug. 23, 2004 
               
               
                 2269 
                 Table_2269_MCL_964_52324.txt 
                 182,429 
                 Aug. 23, 2004 
               
               
                 2270 
                 Table_2270_MCL_966_52325.txt 
                 182,395 
                 Aug. 23, 2004 
               
               
                 2271 
                 Table_2271_MCL_968_52326.txt 
                 182,403 
                 Aug. 23, 2004 
               
               
                 2272 
                 Table_2272_MCL_970_52327.txt 
                 182,434 
                 Aug. 23, 2004 
               
               
                 2273 
                 Table_2273_NMZ_2231_52834.txt 
                 182,506 
                 Aug. 23, 2004 
               
               
                 2274 
                 Table_2274_NMZ_2242_52835.txt 
                 182,434 
                 Aug. 23, 2004 
               
               
                 2275 
                 Table_2275_NMZ_2254_52846.txt 
                 182,612 
                 Aug. 23, 2004 
               
               
                 2276 
                 Table_2276_NMZ_2416_53376.txt 
                 182,442 
                 Aug. 23, 2004 
               
               
                 2277 
                 Table_2277_PMBL_1048_52288.txt 
                 182,443 
                 Aug. 23, 2004 
               
               
                 2278 
                 Table_2278_PMBL_1053_52289.txt 
                 182,385 
                 Aug. 23, 2004 
               
               
                 2279 
                 Table_2279_PMBL_1920_53016.txt 
                 182,435 
                 Aug. 23, 2004 
               
               
                 2280 
                 Table_2280_PMBL_1921_51713.txt 
                 182,362 
                 Aug. 23, 2004 
               
               
                 2281 
                 Table_2281_PMBL_1923_51712.txt 
                 182,440 
                 Aug. 23, 2004 
               
               
                 2282 
                 Table_2282_PMBL_1924_51711.txt 
                 182,419 
                 Aug. 23, 2004 
               
               
                 2283 
                 Table_2283_PMBL_1935_52290.txt 
                 182,426 
                 Aug. 23, 2004 
               
               
                 2284 
                 Table_2284_PMBL_1941_52291.txt 
                 182,477 
                 Aug. 23, 2004 
               
               
                 2285 
                 Table_2285_PMBL_1942_52292.txt 
                 182,441 
                 Aug. 23, 2004 
               
               
                 2286 
                 Table_2286_PMBL_1943_52293.txt 
                 182,492 
                 Aug. 23, 2004 
               
               
                 2287 
                 Table_2287_PMBL_1945_52825.txt 
                 182,346 
                 Aug. 23, 2004 
               
               
                 2288 
                 Table_2288_PMBL_1946_52826.txt 
                 182,211 
                 Aug. 23, 2004 
               
               
                 2289 
                 Table_2289_PMBL_1948_52294.txt 
                 182,305 
                 Aug. 23, 2004 
               
               
                 2290 
                 Table_2290_PMBL_1949_52297.txt 
                 182,453 
                 Aug. 23, 2004 
               
               
                 2291 
                 Table_2291_PMBL_1989_52298.txt 
                 182,376 
                 Aug. 23, 2004 
               
               
                 2292 
                 Table_2292_PMBL_1992_52299.txt 
                 182,469 
                 Aug. 23, 2004 
               
               
                 2293 
                 Table_2293_PMBL_1993_52300.txt 
                 182,356 
                 Aug. 23, 2004 
               
               
                 2204 
                 Table_2294_PMBL_2002_52301.txt 
                 182,424 
                 Aug. 23, 2004 
               
               
                 2295 
                 Table_2295_PMBL_2019_52302.txt 
                 182,358 
                 Aug. 23, 2004 
               
               
                 2296 
                 Table_2296_PMBL_2020_52303.txt 
                 182,617 
                 Aug. 30, 2004 
               
               
                 2297 
                 Table_2297_PMBL_2092_52304.txt 
                 182,611 
                 Aug. 30, 2004 
               
               
                 2298 
                 Table_2298_PMBL_484_52279.txt 
                 182,564 
                 Aug. 30, 2004 
               
               
                 2299 
                 Table_2299_PMBL_546_53018.txt 
                 182,646 
                 Aug. 28, 2004 
               
               
                 2300 
                 Table_2300_PMBL_570_52281.txt 
                 182,653 
                 Aug. 28, 2004 
               
               
                 2301 
                 Table_2301_PMBL_621_52282.txt 
                 182,458 
                 Aug. 28, 2004 
               
               
                 2302 
                 Table_2302_PMBL_691_52283.txt 
                 182,463 
                 Aug. 28, 2004 
               
               
                 2303 
                 Table_2303_PMBL_791_52284.txt 
                 182,606 
                 Aug. 28, 2004 
               
               
                 2304 
                 Table_2304_PMBL_824_52285.txt 
                 182,716 
                 Aug. 28, 2004 
               
               
                 2305 
                 Table_2305_PMBL_906_52286.txt 
                 182,549 
                 Aug. 28, 2004 
               
               
                 2306 
                 Table_2306_PMBL_994_52287.txt 
                 182,707 
                 Aug. 28, 2004 
               
               
                 2307 
                 Table_2307_PTCL_2311_52837.txt 
                 182,602 
                 Aug. 28, 2004 
               
               
                 2308 
                 Table_2308_PTCL_2312_52838.txt 
                 182,690 
                 Aug. 28, 2004 
               
               
                 2309 
                 Table_2309_PTCL_2315_52839.txt 
                 182,718 
                 Aug. 28, 2004 
               
               
                 2310 
                 Table_2310_PTCL_2318_52841.txt 
                 182,568 
                 Aug. 28, 2004 
               
               
                 2311 
                 Table_2311_PTCL_2319_52840.txt 
                 182,541 
                 Aug. 28, 2004 
               
               
                 2312 
                 Table_2312_PTCL_2320_53292.txt 
                 182,652 
                 Aug. 28, 2004 
               
               
                 2313 
                 Table_2313_PTLD_1817_52820.txt 
                 182,507 
                 Aug. 28, 2004 
               
               
                 2314 
                 Table_2314_PTLD_1824_52819.txt 
                 182,673 
                 Aug. 28, 2004 
               
               
                 2315 
                 Table_2315_PTLD_1981_52818.txt 
                 182,480 
                 Aug. 28, 2004 
               
               
                 2316 
                 Table_2316_PTLD_1986_52817.txt 
                 182,509 
                 Aug. 28, 2004 
               
               
                 2317 
                 Table_2317_SLL_1151_52374.txt 
                 182,653 
                 Aug. 28, 2004 
               
               
                 2318 
                 Table_2318_SLL_1153_52375.txt 
                 182,426 
                 Aug. 28, 2004 
               
               
                 2319 
                 Table_2319_SLL_1155_52376.txt 
                 182,449 
                 Aug. 28, 2004 
               
               
                 2320 
                 Table_2320_SLL_1156_52377.txt 
                 182,557 
                 Aug. 28, 2004 
               
               
                 2321 
                 Table_2321_SLL_1158_52378.txt 
                 182,490 
                 Aug. 28, 2004 
               
               
                 2322 
                 Table_2322_SLL_1213_53026.txt 
                 182,692 
                 Aug. 27, 2004 
               
               
                 2323 
                 Table_2323_SLL_1214_51723.txt 
                 182,570 
                 Aug. 27, 2004 
               
               
                 2324 
                 Table_2324_SLL_1216_53027.txt 
                 182,454 
                 Aug. 27, 2004 
               
               
                 2325 
                 Table_2325_SLL_1217_53028.txt 
                 182,541 
                 Aug. 27, 2004 
               
               
                 2326 
                 Table_2326_SLL_1218_52379.txt 
                 182,555 
                 Aug. 27, 2004 
               
               
                 2327 
                 Table_2327_SLL_1220_52380.txt 
                 182,512 
                 Aug. 27, 2004 
               
               
                 2328 
                 Table_2328_SLL_1229_52381.txt 
                 182,500 
                 Aug. 27, 2004 
               
               
                 2329 
                 Table_2329_SLL_1231_52382.txt 
                 182,436 
                 Aug. 27, 2004 
               
               
                 2330 
                 Table_2330_SLL_1235_52383.txt 
                 182,465 
                 Aug. 27, 2004 
               
               
                 2331 
                 Table_2331_SLL_1236_52384.txt 
                 182,698 
                 Aug. 27, 2004 
               
               
                 2332 
                 Table_2332_SLL_1238_52385.txt 
                 182,402 
                 Aug. 27, 2004 
               
               
                 2333 
                 Table_2333_SLL_1240_52386.txt 
                 182,578 
                 Aug. 27, 2004 
               
               
                 2334 
                 Table_2334_SLL_1620_52387.txt 
                 182,607 
                 Aug. 27, 2004 
               
               
                 2335 
                 Table_2335_SPL_2061_52804.txt 
                 182,693 
                 Aug. 27, 2004 
               
               
                 2336 
                 Table_2336_SPL_2074_52805.txt 
                 182,658 
                 Aug. 27, 2004 
               
               
                 2337 
                 Table_2337_SPL_2075_52806.txt 
                 182,548 
                 Aug. 27, 2004 
               
               
                 2338 
                 Table_2338_SPL_2077_52807.txt 
                 182,653 
                 Aug. 27, 2004 
               
               
                 2339 
                 Table_2339_SPL_2079_52808.txt 
                 182,652 
                 Aug. 27, 2004 
               
               
                 2340 
                 Table_2340_SPL_2104_52809.txt 
                 182,643 
                 Aug. 27, 2004 
               
               
                 2341 
                 Table_2341_SPL_2105_52810.txt 
                 182,682 
                 Aug. 27, 2004 
               
               
                 2342 
                 Table_2342_SPL_2106_52811.txt 
                 182,585 
                 Aug. 27, 2004 
               
               
                 2343 
                 Table_2343_SPL_2256_52812.txt 
                 182,721 
                 Aug. 27, 2004 
               
               
                 2344 
                 Table_2344_SPL_2257_52813.txt 
                 182,754 
                 Aug. 27, 2004 
               
               
                 2345 
                 Table_2345_SPL_2258_52814.txt 
                 182,578 
                 Aug. 27, 2004 
               
               
                 2346 
                 Table_2346_SPL_2259_52815.txt 
                 182,644 
                 Aug. 27, 2004 
               
               
                 2347 
                 Table_2347_SPL_2260_52816.txt 
                 182,662 
                 Aug. 27, 2004 
               
               
                 2348 
                 Table_2348_trDLBCL_1332_52305.txt 
                 182,606 
                 Aug. 27, 2004 
               
               
                 2349 
                 Table_2349_trDLBCL_1336_53020.txt 
                 182,204 
                 Aug. 27, 2004 
               
               
                 2350 
                 Table_2350_trDLBCL_1338_52307.txt 
                 182,460 
                 Aug. 27, 2004 
               
               
                 2351 
                 Table_2351_trDLBCL_1353_52308.txt 
                 182,637 
                 Aug. 27, 2004 
               
               
                 2352 
                 Table_2352_trDLBCL_1357_52309.txt 
                 182,640 
                 Aug. 27, 2004 
               
               
                 2353 
                 Table_2353_trDLBCL_1508_52310.txt 
                 182,613 
                 Aug. 27, 2004 
               
               
                 2354 
                 Table_2354_trDLBCL_1520_52311.txt 
                 182,675 
                 Aug. 27, 2004 
               
               
                 2355 
                 Table_2355_trDLBCL_1535_52312.txt 
                 182,651 
                 Aug. 27, 2004 
               
               
                 2356 
                 Table_2356_trDLBCL_1782_52313.txt 
                 182,621 
                 Aug. 27, 2004 
               
               
                 2357 
                 Table_2357_trDLBCL_1784_52314.txt 
                 182,752 
                 Aug. 27, 2004 
               
               
                 2358 
                 Table_2358_trDLBCL_1786_52725.txt 
                 182,570 
                 Aug. 24, 2004 
               
               
                 — 
                 Table of Contents.txt 
                 146,716 
                 Sep. 2, 2004 
               
               
                   
               
            
           
           
               
            
               
                 Disc 22 of 22 
               
            
           
           
               
               
               
               
            
               
                   
                 File Name 
                 File size (bytes) 
                 Date Created 
               
               
                   
                   
               
            
           
           
               
               
               
               
            
               
                   
                 GeneData.txt 
                 9,800,834 
                 Aug. 31, 2004 
               
               
                   
                 GeneID.txt 
                 319,333 
                 Aug. 31, 2004 
               
               
                   
                 PredictionResults.txt 
                 50,889 
                 Sep. 2, 2004 
               
               
                   
                 SampleID.txt 
                 10,117 
                 Sep. 2, 2004 
               
               
                   
                 SubtypePredictor.txt 
                 16,614 
                 Aug. 31, 2004 
               
               
                   
                 Table of contents.txt 
                 255 
                 Sep. 2, 2004 
               
               
                   
                   
               
            
           
         
       
     
     As stated above, the foregoing is merely intended to illustrate various embodiments of the present invention. The specific modifications discussed above are not to be construed as limitations on the scope of the invention. It will be apparent to one skilled in the art that various equivalents, changes, and modifications may be made without departing from the scope of the invention, and it is understood that such equivalent embodiments are to be included herein. All references cited herein are incorporated by reference as if fully set forth herein. 
     Abbreviations used herein: ABC, activated B-cell-like diffuse large B cell lymphoma; BL, Burkitt lymphoma; CHOP, cyclophosphamide, doxorubicine, vincristine, and prednisone; CI, confidence interval; CNS, central nervous system; DLBCL, diffuse large B-cell lymphoma; ECOG, Eastern Cooperative Oncology Group; EST, expressed sequence tag; FACS, fluorescence-activated cell sorting; FH, follicular hyperplasia; FL, follicular lymphoma; GCB, germinal center B-cell-like diffuse large B cell lymphoma; IPI, International Prognostic Index; LPC, lymphoplasmacytic lymphoma; LPS, linear predictor score; MALT, mucosa-associated lymphoid tissue lymphomas; MCL, mantle cell lymphoma; MHC, major histocompatibility complex; NA, not available; NK, natural killer; NMZ, nodal marginal zone lymphoma; PCR, polymerase chain reaction; PMBL, primary mediastinal B-cell lymphoma; PTLD, post-transplant lymphoproliferative disorder; REAL, Revised European-American Lymphoma; RPA, RNase protection assay; RR, relative risk of death; RT-PCR, reverse transcriptase polymerase chain reaction; SAGE, serial analysis of gene expression; SLL, small lymphocytic lymphoma; WHO, World Health Organization. 
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         3. Alizadeh, A. A., et al. 2000. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 403:503-511. 
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         7. Cho, R. J., et al. 1998. A genome-wide transcriptional analysis of the mitotic cell cycle. Mol Cell 2:65-73. 
         8. Chu, S., et al. 1998. The transcriptional program of sporulation in budding yeast. Science 282:699-705. 
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