Patent Publication Number: US-5250546-A

Title: Amino-alcohol derivatives and processes for their preparation

Description:
This application is a continuation of application Ser. No. 07/191,743, filed on May 6, 1988, now abandoned, which is a continuation of application Ser. No. 06/778,967, filed Sep. 23, 1985, abandoned. 
    
    
     BACKGROUND OF THE INVENTION 
     1. Field of the Invention 
     This invention relates to novel amino-alcohol derivatives and more particularly to amino-alcohol derivatives of the formula (I), ##STR2## where R 1  is a straight or branched alkyl group having 3 to 8 carbon atoms, R 2  and R 3  are each a lower alkyl group, or R 2  and R 3  form a 5- to 7-membered ring together with the adjacent nitrogen atom which may have an oxygen atom attached thereto, R 4  is a hydrogen atom or a lower alkyl group, R 5  is a hydrogen atom or a lower alkyl group, X is a hydrogen or halogen atom or a lower alkyl or lower alkoxy group, and n is an integer of 2 or 3, or acid addition salts thereof. The invention further relates to processes for preparing these compounds. 
     2. Description of the Prior Art 
     As has been strongly suggested in the art, glutamic acid acts as an excitatory neurotransmitter at the central nervous systems of higher animals and at the neuromuscular junctions of lower animals [&#34;Glutamate as a Neurotransmitter&#34; edited by G. D. Chiara &amp; G. L. Gessa: Raven Press, New York, 1981 and H. M. Gerschenfeld: Physiol. Rev., 53, 1-119 (1973)]. It has also been reported that dystropy, rigidity, tremors, convulsions and the like are induced by the administration of kainic acid, domoic acid, quisqualic acid, ibotenic acid or the like, which acids are extremely strong agonists for glutamic acid in higher animals [Oleny et al.: Brain Res., 77, 507-512 (1974)]. 
     It is known that as aging proceeds, the central and peripheral nervous systems would undergo hypoergia to develop Parkinson&#39;s disease, motoneuron disorders, dementia, tremors, spinocerebellar degeneracy and the like. These diseases are considered to be attributable to off-balanced equilibration between excitatory nerves and inhibitory nerves (for example, the equilibration between glutamic acid and GABA) due to loss of neurons at certain specific sites or overall hypoergia of the nervous systems [Toshishige Hirai: Shinkei Shimpo, 17, 69 (1973)]. 
     With the foregoing in view, medicines that can selectively block glutamic acid are useful for the therapy of neuropathy from which the senile would most often suffer and which would involve such complaints as vertigo, shoulder discomfort, convulsions, tremors and the like, all of them resulting from off-balanced nervous systems or hyperstenia in muscle discharge. 
     Glutamic acid also acts as an excitatory neurotransmitter for neuromuscular junctions of insects. Chemicals capable of blocking glutamic acid are therefore suitable for agricultural use for their ability to reduce and weaken insects&#39; activities [Morifusa Eto: Kagaku to Seibutsu, 21, 725 (1983)]. 
     It has now been found that amino-alcohol derivatives of the formula (I) above have excellent blocking effects against glutamic acid as well as neuraxial muscle relaxing effects, i.e. rigidity reducing and releasing effects on anemic decerebrate rigidity samples. 
     This result suggests that the inventive compounds are useful for the therapy of a complaint which would have spastic paralysis and rigidity and these compounds are expected to suppress or release dyskinasis, athetosis, myoclonus, tic, tremors, dystonia and ballismus of neuropathy. 
     Some compounds are known which are structurally similar to the compounds contemplated by the present invention. Such known compounds are 2-(2-dimethylaminoethylamino)-1-phenylpropan-1-ol [Sv. Zikolova and L. Zhelyazkov: Tr. Nauchno-Izsled. Inst. Farm., 3, 14-19 (1961) (CA, 61, 9485b)], 1-phenyl-2-(2-piperidinoethylamino)propan-1-ol and 1-phenyl-2-(2-pyrrolidinoethylamino)propan-1-ol [ibid., L. Zhelyazkov, A. Georgiev, Sv. Zikolova, P. Manolov, L Daleva and M. Kazandzhiev: Tr. Nauchnoizsled. Khim.-Farm. Inst., 1972, 7, 33-53 (CA, 79, 27099g) and L. Daleva, P. Manolov: Tr. Nauchnoizsled. Khim.-Farm. Inst., 1972, 7, 229-240 (CA, 79, 27213g)]and 2-(2-morpholinoethyl- amino)-1-phenylpropan-1-ol [Sv. Zikolova and L. Zhelyazkov: Farmatsiya, 14, (5), 16-21 (1964) (CA, 62, 13135g)]. These prior art publications however are silent as to whether the known compounds would have blocking effects against glutamic acid. Experiments conducted by the present inventors show that those compounds are only marginal in their glutamic acid blocking effects and in their rigidity reducing and releasing effects as compared with the compounds of the invention. 
     SUMMARY OF THE INVENTION 
     It is an object of the present invention to provide novel amino-alcohol derivatives of the formula (I) above which have excellent blocking effects against glutamic acid and rigidity reducing and releasing effects and hence are effectively useful as medicines and agricultural chemicals. 
     Another object of the invention is to provide processes for preparing such compounds. 
     These and other objects and features of the invention can be attained by the provision of an amino-alcohol derivative of the formula (I), ##STR3## where R 1  is a straight or branched alkyl group having 3 to 8 carbon atoms, R 2  and R 3  are each a lower alkyl group, or R 2  and R 3  form a 5- to 7-membered ring together with the adjacent nitrogen atom which may have an oxygen atom attached thereto, R 4  is a hydrogen atom or a lower alkyl group, R 5  is a hydrogen atom or a lower alkyl group, X is a hydrogen or halogen atom or a lower alkyl or lower alkoxy group, n is an integer of 2 or 3, or an acid addition salt thereof. 
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     Amino-alcohol derivatives of the present invention contain two types of compounds, i.e. a compound of the formula (Ia) and a compound of the formula (Ib), ##STR4## where R&#39; is a lower alkyl group, and R 1 , R 2 , R 3 , R 5 , X and n are as defined previously. 
     Both of these compounds of the invention can be prepared, for example, by one of the following processes. 
     Process 1 
     In accordance with the following reaction scheme, a compound of the formula (II) is reacted with a compound of the formula (III) to prepare the desired compound (Ia), ##STR5## where Y 1  is a halogen atom or a tosyloxy group, and R 1 , R 2 , R 3 , R 5 , X and n are as defined previously. 
     The reaction of the compound (II) with the compound (III) is effected at 50° to 150° C. This reaction may be conducted without a solvent under normal conditions, but it is possible to use an inert solvent. 
     Process 2 
     In accordance with the following reaction scheme, the compound (Ia) is reacted with a compound of the formula (IV) to prepare the desired compound (Ib), ##STR6## R&#39; is a lower alkyl group, and R 1 , R 2 , R 3 , R 5 , X and n are as defined previously. 
     This reaction is conducted by reacting an alcoholate anion of the compound (Ia) with the compound (IV). The alcoholate is obtained by treating the compound (Ia) with a base such as sodium hydride in an organic solvent such as benzene or toluene at room temperature to 150° C. 
     Process 3 
     In accordance with the following reaction scheme, a desired compound of the formula (Ia&#39;) is obtained by reducing a compound of the formula (V), ##STR7## where R 6  is a hydrogen atom or a lower alkyl group, and R 1 , R 2 , R 3 , X and n are as defined previously. 
     The compound (V) which is a starting material for this reaction is obtained by acylating a compound of the formula (Ia&#34;), ##STR8## where R 1 , R 2 , R 3 , X and n are as defined previously. 
     The reaction is effected with use of a reducing agent such as lithium aluminum hydride in a solvent such as tetrahydrofuran or ether at 0° C. to the boiling point of the solvent. 
     Process 4 
     In accordance with the following reaction scheme, a compound of the formula (VI) is reacted with a compound of the formula (VII) to prepare a desired compound of the formula (I), ##STR9## where Y 2  is a halogen atom, and R 1 , R 2 , R 3 , R 4 , R 5 , X and n are as defined previously. 
     The reaction of the compound (VI) with the compound (VII) is effected with or without a solvent at 50° to 150° C. for 1 to 10 hours. 
     Process 5 
     In accordance with the following reaction scheme, the desired compound (Ia) is obtained by reducing a compound of the formula (VIII), ##STR10## where R 1 , R 2 , R 3 , R 5 , X and n are as defined previously. 
     The reduction is effected in the usual manner. For example, the following reaction techniques may be employed. 
     1) Hydrogenation in the presence of a catalyst such as Raney-nickel, platinum, palladium-carbon or the like in a solvent such as methanol or ethanol 
     2) Reduction using a metal hydride complex, for example, sodium borohydride in a solvent such as methanol or ethanol, or lithium aluminum hydride in an organic solvent such as ether or tetrahydrofuran 
     3) Reduction using an aluminum alkoxide such as aluminum isopropoxide in an organic solvent such as isopropanol or the like 
     Process 6 
     In accordance with the following reaction scheme, the desired compound (I) is obtained by reacting a compound of the formula (IX) with the compound (VII) under reducing conditions, ##STR11## where A is ##STR12## and R 1 , R 2 , R 3 , R 4 , R 5 , X and n are as defined previously. 
     In the case where A is ##STR13## the reaction is effected in the presence of zinc and sulfurous acid in a solvent such as methanol or ethanol at 50° to 150° C. for 0.5 to 5 hours. In the case where A is ##STR14## the reaction is effected by hydrogenation in the presence of a catalyst such as Raney-nickel, platinum, palladium-carbon or the like in a solvent such as methanol or ethanol, or by reduction using a metal hydride complex, for example, sodium cyanoborohydride in a solvent such as methanol or ethanol, preferably in a pH range of 6 to 9, or sodium borohydride in the presence of acetic acid and sodium acetate in a solvent such as alcohol-containing water. 
     Process 7 
     In accordance with the following reaction scheme, a desired compound of the formula (Ia&#34;) is obtained by hydrolyzing a compound of the formula (X), ##STR15## where R 1 , R 2 , R 3 , X and n are as defined previously. 
     This reaction is effected by hydrolyzing the compound (X) in the presence of a base such as sodium hydroxide in alcohol-containing water at 50° to 100° C. 
     The amino-alcohol derivatives (I) thus prepared can be converted in conventional manner to their acid addition salts. Acid addition salts useful in the invention include, for example, hydrochlorides, hydrobromides, phosphates, sulfates, p-toluene-sulfonates, fumarates, citrates, maleates, tartrates and the like. 
     Each of the compounds contemplated by the present invention includes its stereoisomers, i.e. an erythro form (1RS,2SR) and a threo form (1RS,2RS), and its optical isomers (1R,2S), (1S,2R), (1R,2R) and (1S,2S). It is to be noted that these two types of isomers are within the scope of the invention. 
     The following compounds are particularly typical of the compounds (I) of the present invention. 
     Compound 1 : (1RS,2SR)-1-phenyl-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 2 : (1RS,2RS)-1-phenyl-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 3 : (1RS,2SR)-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol dihydrochloride 
     Compound 4 : (1RS,2RS)-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol dihydrochloride 
     Compound 5 : (1RS,2SR)-1-phenyl-2-(3-piperidinopropylamino)heptan-1-ol dihydrochloride 
     Compound 6 : (1RS,2RS)-1-phenyl-2-(3-piperidinopropylamino)heptan-1-ol dihydrochloride 
     Compound 7 : (1RS,2SR)-1-phenyl-2-(3-piperidinopropylamino)octan-1-ol dihydrochloride 
     Compound 8 : (1RS,2RS)-1-phenyl-2-(3-piperidinopropylamino)octan- 1-ol dihydrochloride 
     Compound 9 : (1RS,2SR)-1-phenyl-2-(3-piperidinopropylamino)nonan-1-ol dihydrochloride 
     Compound 10: (1RS,2RS)-1-phenyl-2-(3-piperidinopropylamino)nonan-1-ol dihydrochloride 
     Compound 11: (1RS,2SR)-1-phenyl-2-(3-piperidinopropylamino)decan-1-ol dihydrochloride 
     Compound 12: (1RS,2RS)-1-phenyl-2-(3-piperidinopropylamino)decan-1-ol dihydrochloride 
     Compound 13: (1RS,2SR)-3-methyl-1-phenyl-2-(3-piperidinopropylamino)butan-1-ol dihydrochloride 
     Compound 14: (1RS,2RS)-3-methyl-1-phenyl-2-(3-piperidinopropylamino)butan-1-ol dihydrochloride 
     Compound 15: (1RS,2SR)-4-methyl-1-phenyl-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 16: (1RS,2RS)-4-methyl-1-phenyl-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 17: (1R,2S)-4-methyl-1-phenyl-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 18: (1S,2R)-4-methyl-1-phenyl-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 19: (1S,2S)-4-methyl-1-phenyl-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 20: (1R,2R)-4-methyl-1-phenyl-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 21: (1RS,2SR)-5-methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol dihydrochloride 
     Compound 22: (1RS,2RS)-5-methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol dihydrochloride 
     Compound 23: (1RS,2SR)-4-methyl-1-phenyl-2-(3-pyrrolidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 24: -methyl-1-phenyl-2-(3-pyrrolidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 25: (1RS,2SR)-4-methyl-2-(3-morpholinopropylamino)-1-phenylpentan-1-ol dihydrochloride 
     Compound 26: (1RS,2RS)-4-methyl-2-(3-morpholinopropylamino)-1-phenylpentan-1-ol dihydrochloride 
     Compound 27: (1RS,2SR)-2-(3-dimethylaminopropylamino)-4-methyl-1-phenylpentan-1-ol dihydrochloride 
     Compound 28: (1RS,2RS)-2-(3-dimethylaminopropylamino)-4-methyl-1-phenylpentan-1-ol dihydrochloride 
     Compound 29: (1RS,2SR)-4-methyl-1-phenyl-2-(2-piperidinoethylamino)pentan-1-ol dihydrochloride 
     Compound 30: (1RS,2RS)-4-methyl-1-phenyl-2-(2-piperidinoethylamino)pentan-1-ol dihydrochloride 
     Compound 31: (1RS,2SR)-4-methyl-1-phenyl-2-(2-pyrrolidinoethylamino)pentan-1-ol dihydrochloride 
     Compound 32: (1RS,2RS)-4-methyl-1-phenyl-2-(2-pyrrolidinoethylamino)pentan-1-ol dihydrochloride 
     Compound 33: (1RS,2SR)-4-methyl-2-[3-(perhydroazepin-1-yl)propylamino]-1-phenylpentan-1-ol dihydrochloride 
     Compound 34: (1RS,2RS)-4-methyl-2-[3-(perhydroazepin-1-yl)propylamino]-1-phenylpentan-1-ol dihydrochloride 
     Compound 35: (1RS,2SR)-5-methyl-1-phenyl-2-(3-pyrrolidinopropylamino)hexan-1-ol dihydrochloride 
     Compound 36: (1RS,2RS)-5-methyl-1-phenyl-2-(3-pyrrolidinopropylamino)hexan-1-ol dihydrochloride 
     Compound 37: (1RS,2SR)-5-methyl-2-(3-morpholinopropylamino)-1-phenylhexan-1-ol dihydrochloride 
     Compound 38: (1RS,2RS)-5-methyl-2-(3-morpholinopropylamino)-1-phenylhexan-1-ol dihydrochloride 
     Compound 39: (1RS,2SR)-2-(3-dimethylaminopropylamino)-5-methyl-1-phenylhexan-1-ol dihydrochloride 
     Compound 40: (1RS,2RS)-2-(3-dimethylaminopropylamino)-5-methyl-1-phenylhexan-1-ol dihydrochloride 
     Compound 41: (1RS,2SR)-5-methyl-1-phenyl-2-(2-piperidinoethylamino)hexan-1-ol dihydrochloride 
     Compound 42: (1RS,2RS)-5-methyl-1-phenyl-2-(2-piperidinoethylamino)hexan-1-ol dihydrochloride 
     Compound 43: (1RS,2SR)-5-methyl-1-phenyl-2-(2-pyrrolidinoethylamino)hexan-1-ol dihydrochloride 
     Compound 44: (1RS,2RS)-5-methyl-1-phenyl-2-(2-pyrrolidinoethylamino)hexan-1-ol dihydrochloride 
     Compound 45: (1RS,2SR)-5-methyl-2-[3-(perhydroazepin-1-yl)propylamino]-1-phenylhexan-1-ol dihydrochloride 
     Compound 46: (1RS,2RS)-5-methyl-2-[3-(perhydroazepin-1-yl)propylamino]-1-phenylhexan-1-ol dihydrochloride 
     Compound 47: (1RS,2SR)-4-methyl-1-(2-methylphenyl)-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 48: (1RS,2RS)-4-methyl-1-(2-methylphenyl)-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 49: (1RS,2SR)-4-methyl-1-(3-methylphenyl)-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 50: (1RS,2RS)-4-methyl-1-(3-methylphenyl)-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 51: (1RS,2SR)-4-methyl-1-(4-methylphenyl)-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 52: (1RS,2RS)-4-methyl-1-(4-methylphenyl)-2-(3-piperidinopropylamino)pentan-1-ol dihyrochloride 
     Compound 53: (1RS,2SR)-1-(4-methoxyphenyl)-4-methyl-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 54: (1RS,2RS)-1-(4-methoxyphenyl)-4-methyl-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 55: (1RS,2SR)-1-(4-fluorophenyl)-4-methyl-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 56: (1RS,2RS)-1-(4-fluorophenyl)-4-methyl-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 57: (1RS,2SR)-1-(4-chlorophenyl)-4-methyl-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 58: (1RS,2RS)-1-(4-chlorophenyl)-4-methyl-2-(3-piperidinopropylamino)pentan-1-ol dihydrochloride 
     Compound 59: (1RS,2SR)-5-methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol methylether dihydrochloride 
     Compound 60: (1RS,2RS)-5-methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol methylether dihydrochloride 
     Compound 61: (1RS,2SR)-5-methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol ethylether dihydrochloride 
     Compound 62: (1RS,2RS)-5-methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol ethylether dihydrochloride 
     Compound 63: (1RS,2SR)-2-[methyl-(3-piperidinopropyl)amino]-5-methyl-1-phenylhexan-1-ol dihydrochloride 
     Compound 64: (1RS,2RS)-2-[methyl-(3-piperidinopropyl)amino]-5-methyl-1-phenylhexan-1-ol dihydrochloride 
     Compound 65: (1RS,2SR)-2-[ethyl-(3-piperidinopropyl)amino]-5-methyl-1-phenylhexan-1-ol dihydrochloride 
     Compound 66: (1RS,2RS)-2-[ethyl-(3-piperidinopropyl)amino]-5-methyl-1-phenylhexan-1-ol dihydrochloride 
     The effectiveness of the compounds (I) according to the invention was determined with respect to the blocking effects against glutamic acid, the neuraxial muscle relaxing effects (the rigidity reducing and releasing effects on anemic decerebrate rigidity) and the toxicity levels. The following compounds were used for comparative purposes. 
     Comparative compound 1: (1RS,2SR)-1-phenyl-2-(2-piperidinoethylamino)propan-1-ol dihydrochloride 
     Comparative compound 2: (1RS,2SR)-1-phenyl-2-(2-pyrrolidinoethylamino)propan-1-ol dihydrochloride 
     Comparative compound 3: (1RS,2SR)-2-(2-morpholinoethylamino)-1-phenylpropan-1-ol dihydrochloride 
     Comparative compound 4: (1RS,2SR)-2-(2-dimethylaminoethylamino)-1-phenylpropan-1-ol dihydrochloride 
     Comparative compound 5: tolperisone hydrochloride 
     EXPERIMENT 1 
     Blocking Effects against Glutamic Acid at Neuromuscular Junctions of Crayfish 
     The method of Ishida et al. [J. Physiol., 298, 301-319 (1980)] and that of Shinozaki et al. [Comp. Biochem. Physio., 70c, 49-58 (1981)] followed. The opener muscles of the first walking legs of crayfish were used as experimental materials. The neuromuscular sample was held in a bath in which a physiological solution [composition (mM): NaCl (195), CaCl 2  (18), KCl (5.4), tris-maleate buffer (pH 7.5; 10), glucose (11)] for use with the crayfish was perfused at room temperature and at a constant flow rate. A glass micro-electrode filled with a 3M-KCl solution was inserted in a central part of the muscle fiber to intracellularly record changes in the potential of the muscular cell membrane. 
     The blocking effect of each test compound against glutamic acid was evaluated in terms of the suppression rate to depolarization which was induced by bath-applying L-glutamic acid (10 -4  M) in a 5-minute pretreatment with a solution of the test compound (2×10 -4  M). The results are shown in Table 1. 
     
                       TABLE 1                                                     
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          Blocking rate          Blocking rate                            
          against                against                                  
          glutamic               glutamic                                 
Test compound                                                             
          acid (%)   Test compound                                        
                                 acid (%)                                 
______________________________________                                    
Inventive            Inventive                                            
compound             compound                                             
 1        98         35          100                                      
 3        99         37          99                                       
 5        100        39          100                                      
 6        100        41          94                                       
 7        98         43          95                                       
11        100        45          100                                      
13        96         47          100                                      
15        100        49          100                                      
16        95         51          100                                      
17        100        52          93                                       
18        97         53          91                                       
19        100        55          99                                       
20        98         57          99                                       
21        100        58          97                                       
22        100        59          97                                       
23        97         65          99                                       
                     Comparative                                          
                     compound                                             
25        90          1          59                                       
27        95          3          30                                       
29        93          4          0-50                                     
31        91                                                              
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     EXPERIMENT 2 
     Effects on Anemic Decerebrate Rigidity 
     An anemic decerebrate rigidity sample was prepared principally in accordance with the procedure of Fukuda et al. [Japan. J. Pharmacol., 24, 810 (1974)]. Wistar male rats (body weight: 270 to 350 g) were held on their backs and incised at their cervices under etherization. After the trachea and common carotid arteries were exposed, the trachea was cannulated and the bilateral common carotid arteries and esophagus were then double-ligated and cut. Thereafter, its occipital bone was exposed through which a circular hole was bored to double-ligate the centrally extending basilar artery. As each rat started coming out of anesthetization, its front limbs became rigid. Measurement was conducted by recording electromyographic (EMG) response from the muscle of the forelimb (M. triceps brachii) of the rat in the rigid state. The EMG pulses were converted to accumulated values every 10 seconds and recorded as a histogram on a recorder. 
     The effect of each test compound on the rigidity was evaluated in terms of the suppression rate. This rate was calculated first by determining the area of a decreased EMG pulse part on the histogram upon passage of 10 minutes after administration of a physiological saline solution of each test compound (3 mg/kg) through the femoral vein and then in accordance with the following equation. ##EQU1## where a: EMG pulse area decreased as a result of the administration of the test compound; and 
     A: EMG pulse area when no test compound was administered (control). 
     The results are shown in Table 2. 
     
                       TABLE 2                                                     
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Test compound    Suppression rate (%)                                     
______________________________________                                    
Inventive compound                                                        
 3               17.5                                                     
 5               18.5                                                     
21               65.9                                                     
22               42.3                                                     
35               21.6                                                     
41               23.5                                                     
43               16.1                                                     
45               90.5                                                     
Comparative compound                                                      
 2               2.2                                                      
 3               1.0                                                      
 4               1.1                                                      
 5               4.8                                                      
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     EXPERIMENT 3 
     Acute Toxicity 
     Using ddN male mice, the acute toxicity level of each test compound was determined in accordance with an up-and-down method. Some of the test compounds used were dissolved in physiological saline and administered through the caudal vein. The results are shown in Table 3. 
     
                       TABLE 3                                                     
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                 LD50                                                     
Test compound    (mg/kg) (iv)                                             
______________________________________                                    
Inventive compound                                                        
 3               19.2                                                     
 5               22.1                                                     
15               23.6                                                     
16               28.8                                                     
17               15.4                                                     
19               28.4                                                     
21               13.6                                                     
22               19.0                                                     
35               26.7                                                     
41               29.5                                                     
43               31.9                                                     
45               12.8                                                     
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     The following specific examples and reference examples are given to further illustrate the present invention. 
     EXAMPLE 1 
     (1RS,2SR)-5-Methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol dihydrochloride 
     A mixture of (1RS,2SR)-2-amino-5-methyl-1-phenylhexan-1-ol (415 mg, 2 mmol) and 1-(3-chloropropyl)piperidine (324 mg, 2 mmol) was melted at 70° C. in a nitrogen atmosphere. The mixture was heated at 110° to 120° C. for 3 hours. After being cooled, the reaction mixture was dissolved with heating in ethanol, followed by addition of concentrated hydrochloric acid (0.2 ml). After the mixture was cooled, precipitated crystals were collected by filtration and washed with ethanol. The crystals were recrystallized from ethanol to obtain 0.27 g of the title compound as white crystals (yield: 33%). 
     mp: 266°-267° C. (dec) 
     
         ______________________________________                                    
IRν.sub.max.sup.KBr (cm.sup.-1):                                       
           3290, 2945, 2650, 2550, 1590, 1445, 1285,                      
           1130, 1090, 950, 735, 700                                      
free base                                                                 
IRν.sub.max.sup.neat (cm.sup.-1):                                      
           3290, 2930, 2860, 2800, 1605, 1460, 1445,                      
           1120, 1040, 695                                                
NMR(CDCl.sub.3)δ:                                                   
           0.60-0.86(6H, m, CH(C .sub.--H.sub.3).sub.2)                   
           0.86-1.85(13H, m, C .sub.--H.sub.2 C .sub.--H.sub.2 C .sub.--H(
           CH.sub.3).sub.2,                                               
            ##STR16##                                                     
            ##STR17##                                                     
           4.76(1H, d, J=4Hz, C .sub.--HO)                                
           7.24(5H, m, aromatic protons)                                  
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     EXAMPLE 2 
     (1RS,2RS)-5-Methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol dihydrochloride 
     A mixture of (1RS,2RS)-2-amino-5-methyl-1- phenylhexan-1-ol (1.04 g, 5 mmol) and 1-(3-chloropropyl)piperidine (0.81 g, 5 mmol) was melted at 70° C. in a nitrogen atmosphere. The mixture was then heated at 110° to 120° C. for 3 hours. After being cooled, the reaction mixture was dissolved with heating in ethanol, followed by addition of concentrated hydrochloric acid (0.5 ml). The resulting mixture was concentrated and the residue was crystallized by treatment with ethanol and hexane. The crystals were collected by filtration, washed with ethanol-hexane and then recrystallized from ethanol-hexane to obtain 1.24 g of the title compound as white crystals (yield: 61%). 
     mp 250°-251° C. (dec) 
     
         ______________________________________                                    
IRν.sub.max.sup.KBr (cm.sup.-1):                                       
           3310, 2950, 2640, 1590, 1450, 1050, 760,                       
           700                                                            
free base                                                                 
IRν.sub.max.sup.neat (cm.sup.-1):                                      
           3300, 2920, 2850, 2800, 1605, 1465, 1445,                      
           1365, 1155, 1120, 1040, 755, 695                               
NMR(CDCl.sub.3)δ:                                                   
           0.68-0.92(6H, m, CH(C .sub.--H.sub.3).sub.2)                   
           0.92-1.81(13H, m, C .sub.--H.sub.2 C .sub.--H.sub.2 C .sub.--H(
           CH.sub.3).sub.2,                                               
            ##STR18##                                                     
            ##STR19##                                                     
           4.22(1H, d, J=8Hz, C .sub.--HO)                                
           7.24(5H, m, aromatic protons)                                  
______________________________________                                    
 
    
     EXAMPLE 3 
     (1RS,2RS)-1-Phenyl-2-(3-piperidinopropylamino)octan-1-ol dihydrochloride 
     A mixture of (1RS,2RS)-2-amino-1-phenyloctan-1-ol (1.77 g, 8 mmol) and 1-(3-chloropropyl)piperidine (1.29 g, 8 mmol) was melted at 70° C. in a nitrogen atmosphere. The mixture was then heated at 110° to 120° C. for 3 hours. The reaction mixture was dissolved with heating in ethanol, followed by addition of concentrated hydrochloric acid (0.67 ml). Ethyl acetate was added and the resulting mixture was allowed to stand. Precipitated crystals were collected by filtration and washed with ethyl acetate and then with hexane to obtain 1.96 g of the title compound as white crystals (yield: 59%). 
     mp: 231°-234° C. (dec) 
     
         ______________________________________                                    
IRν.sub.max.sup.KBr (cm.sup.-1):                                       
           3310, 2925, 2700, 1585, 1450, 1055, 760,                       
           700                                                            
free base                                                                 
IRν.sub.max.sup.neat (cm.sup.-1):                                      
           3280, 2920, 2850, 2800, 1600, 1465, 1450,                      
           1345, 1150, 1120, 1035, 755, 695                               
NMR(CDCl.sub.3)δ:                                                   
           0.68-1.02(3H, m, CH.sub.2 C .sub.--H.sub.3)                    
           1.02-1.09(20H, m, (C .sub.--H.sub.2).sub.5 CH.sub.3,           
            ##STR20##                                                     
            ##STR21##                                                     
           4.24(1H, d, J=8Hz, C .sub.--HO)                                
           7.30(5H, m, aromatic protons)                                  
______________________________________                                    
 
    
     EXAMPLE 4 
     (1RS,2SR)-5-Methyl-1-phenyl-2-(2-piperidinoethyl)hexan-1-ol dihydrochloride 
     A mixture of (1RS,2SR)-2-amino-5-methyl-1-phenylhexan-1-ol (1.04 g, 5 mmol) and 1-(2-chloroethyl)piperidine (0.74 g, 5 mmol) was melted at 70° C. in a nitrogen atmosphere. The mixture was then heated at 110° to 120° C. for 3 hours. After being cooled, the reaction mixture was dissolved in water. The solution was basified with 2N-NaOH and then extracted with ether. The ethereal extract was washed twice with water and once with brine, dried over anhydrous sodium sulfate and then evaporated under reduced pressure. The residue was dissolved in acetone (20 ml), followed by addition of concentrated hydrochloric acid (0.74 ml). Precipitated crystals were collected by filtration and washed with acetone. The crystals were recrystallized from ethanol (10 ml)-ether (2 ml) to obtain 0.34 g of the title compound as white crystals (yield: 17%). 
     mp: 223°-224° C. (dec) 
     
         ______________________________________                                    
IRν.sub.max.sup.KBr (cm.sup.-1):                                       
           3260, 2950, 2700, 2470, 1600, 1450, 1200,                      
           1050, 740, 700                                                 
free base                                                                 
IRν.sub.max.sup.neat (cm.sup.-1):                                      
           3180, 2940, 2860, 2820, 1600, 1445, 1250,                      
           1105, 1050, 760, 695                                           
NMR(CDCl.sub.3)δ:                                                   
           0.76(3H, d, J=6Hz, CHC .sub.--H.sub.3)                         
           0.79(3H, d, J=6Hz, CHC .sub.--H.sub.3                          
           1.00-1.77(11H, m, C .sub.--H.sub.2 C .sub.--H.sub.2 C .sub.--H(
           CH.sub.3).sub.2,                                               
            ##STR22##                                                     
            ##STR23##                                                     
           4.73(1H, d, J=4Hz, C .sub.--HO)                                
           7.30(5H, m, aromatic protons)                                  
______________________________________                                    
 
    
     EXAMPLE 5 
     (1RS,2SR)-5-Methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol dihydrochloride 
     A mixture of (1RS,2SR)-2-amino-5-methyl-1-phenylhexan-1-ol (1.04 g, 5 mmol) and 1-(3-chloropropyl)piperidine (0.81 g, 5 mmol) in benzene (10 ml) was refluxed for 40 hours. After being cooled, the reaction mixture was concentrated under reduced pressure. The residue was dissolved in ethanol (10 ml), followed by addition of 6N-HCl in EtOH (2 ml). Precipitated crystals were collected by filtration and then recrystallized from ethanol to obtain 1.15 g of the title compound as white crystals (yield: 57%). 
     mp 266°-267° C. (dec) 
     EXAMPLE 6 
     (1RS,2SR)-5-Methyl-1-phenyl-2-(3-piperidinopropylamino)hexan- 1-ol dihydrochloride 
     A mixture of (1RS,2SR)-2-amino-5-methyl-1-phenylhexan-1-ol (1.04 g, 5 mmol), 3-piperidinopropyl tosylate hydrochloride (2.00 g, 6 mmol) and sodium bicarbonate (1.05 g, 12.5 mmol) in ethanol (10 ml) was refluxed for 1 hour. After cooling, to the reaction mixture were added ether (100 ml), water (50 ml) and 2N-NaOH (5 ml) and the resulting mixture was well shaken. The ethereal layer was separated and washed three times with water, then once with brine, followed by drying and subsequent concentration under reduced pressure. The residue was dissolved in ethanol and to the solution was added 6N-HCl in EtOH (1.5 ml). Precipitated crystals were collected by filtration and then recrystallized from ethanol to obtain 0.73 g of the title compound as white crystals (yield: 36%). 
     mp: 266°-267° C. (dec) 
     EXAMPLE 7 
     (1RS,2SR)-5-Methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol methyl ether dihydrochloride 
     To a solution of (1RS,2SR)-5-methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol (1.66 g, 5 mmol) in toluene (25 ml) was added sodium hydride (0.14 g, 6 mmol) and the mixture was refluxed for 1 hour. To the reaction mixture was added methyl tosylate (1.12 g, 6 mmol) and the resulting mixture was refluxed for further 1 hour. After being cooled, the mixture was washed twice with water and once with brine, dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The residue was purified by neutral alumina column chromatography (alumina: 40 g, eluent: chloroform) to give 1.1 g of oily matter. To a solution of the matter in acetone (20 ml) was added concentrated hydrochloric acid (0.1 ml) and the mixture was concentrated under reduced pressure. The residue was recrystallized from acetone (10 ml)-ethanol (0.2 ml) to obtain 0.45 g of the title compound as white crystals (yield: 21%). 
     mp: 138°-141° C. 
     
         ______________________________________                                    
IRν.sub.max.sup.KBr (cm.sup.-1):                                       
           3360, 2940, 2640, 1570, 1450, 1120, 1095,                      
           1060, 1010, 740, 695                                           
free base                                                                 
IRν.sub.max.sup.neat (cm.sup.-1):                                      
           2940, 2860, 2810, 1460, 1445, 1150, 1120,                      
           1100, 695                                                      
NMR(CDCl.sub.3)δ:                                                   
           0.70-0.96(6H, m, CH(C .sub.--H.sub.3).sub.2)                   
           1.00-1.70(14H, m, C .sub.--H.sub.2).sub.2 C .sub.--H(C         
           .sub.--H.sub.3).sub.2,                                         
            ##STR24##                                                     
            ##STR25##                                                     
           3.24(3H, s, OC .sub.--H.sub.3)                                 
           4.17(1H, d, J=5Hz, C .sub.--HO)                                
           7.30(5H, m, aromatic protons)                                  
______________________________________                                    
 
    
     EXAMPLE 8 
     (1RS,2SR)-2-[Ethyl-(3-piperidinopropyl)amino]-5-methyl-1-phenylhexan-1-ol dihydrochloride 
     To a cooled mixture of (1RS,2SR)-5-methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol (821 mg, 2.47 mmol) in ether (36 ml) and a 10% NaOH aqueous solution (15 ml) was added dropwise a solution of acetyl chloride (0.21 g, 2.7 mmol) in benzene. The organic layer was separated, washed with brine, dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography to obtain an N-acetylated product (IRν max   neat  : 1620 cm -1 ) of the starting material. To a cooled solution of such compound in tetrahydrofuran (12.4 ml) was added lithium aluminum hydride (0.47 g) and the reaction mixture was refluxed for 3 hours. Ethyl acetate was added with cooling to the mixture to consume excess lithium aluminum hydride and the mixture was then poured into an aqueous saturated sodium sulfate solution. The organic layer was separated by decantation, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: chloroform/methanol =25/1) to give a free base of the title compound. To a solution of the compound in ethanol was added in excess  6N-HCl in EtOH and the mixture was concentrated under reduced pressure. The residue was crystallized by treatment with ether, followed by recrystallization from ethanol-ethyl acetate to obtain 510 mg of the title compound as white crystals (yield: 48%). 
     mp: 190°-193° C. 
     
         ______________________________________                                    
IRν.sub.max.sup.KBr (cm.sup.-1):                                       
           3400, 2950, 2870, 2660, 1450, 1420, 1090,                      
           1050, 1030, 735, 700                                           
free base                                                                 
IRν.sub.max.sup.neat (cm.sup.-1):                                      
           2940, 2870, 2820, 1490, 1465, 1445, 1380,                      
           1365, 1345, 1155, 1125, 1065, 1040, 760,                       
           700                                                            
NMR(CDCl.sub.3)δ:                                                   
           0.80(6H, d, J=6Hz, CH(C .sub.--H.sub.3).sub.2)                 
           1.02(3H, t, J=7Hz, NCH.sub.2 C .sub.--H.sub.3)                 
           1.10-1.82(13H, m, (C .sub.--H.sub.2).sub.2 C .sub.--H(C        
           .sub.--.sub.3).sub.2,                                          
            ##STR26##                                                     
            ##STR27##                                                     
           4.76(1H, d, J=4Hz, C .sub.--HO)                                
           5.40(1H, broad s, O .sub.--H)                                  
           7.04-7.46(5H, m, aromatic protons)                             
______________________________________                                    
 
    
     EXAMPLE 9 
     (1RS,2RS)-5-Methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol dihydrochloride 
     A mixture of 2-bromo-5-methyl-1-phenylhexan-1-ol [prepared from 2-bromo-5-methyl-1-phenylhexan-1-one by usual NaBH 4  -reduction] (1.0 g, 3.69 mmol) and 1-(3-aminopropyl)piperidine (1.05 g, 7.38 mmol) was heated at 110° C. for 4 hours in a nitrogen atmosphere. After being cooled, the reaction mixture was dissolved in lN-HCl (50 ml) and the solution was washed with ether. The aqueous layer was basified with lN-NaOH and then extracted twice with ether. The combined ethereal extract was washed three times with water, dried over anhydrous sodium sulfate and evaporated under reduced pressure. The residue was purified by preparative TLC to give pale yellow oily matter. To a solution of the matter in ethanol was added in excess 18% HCl in EtOH and the resulting mixture was evaporated under reduced pressure. The residue was dissolved with heating in ethanol (15 ml) and to the mixture was then added 10 ml of acetone. The mixture was stirred at room temperature. Precipitated crystals were collected by filtration to obtain 0.52 g of the title compound (yield: 35%). 
     mp: 250°-251° C. (dec) 
     EXAMPLE 10 
     (1RS,2SR)-5-Methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol dihydrochloride 
     To a solution of 1-(3-aminopropyl)piperidine (0.14 g, 1 mmol) in chloroform (2 ml) was added a solution of 2-bromo-5-methyl-1-phenylhexan-1-one [bp: 128°-130° C./2.5 mmHg; prepared from 5-methyl-1-phenylhexan-1-one by usual bromination] (0.54 g, 2 mmol) in chloroform (4 ml) and the mixture was stirred for 4 hours at room temperature in a nitrogen atmosphere. The reaction mixture was concentrated below 30° C. under reduced pressure. To a solution of the residue in methanol (4 ml) was added sodium borohydride (0.08 g) with ice-cooling and the mixture was stirred for 1 hour at room temperature. The reaction mixture was concentrated below 30° C. under reduced pressure. The residue was dissolved in lN-HCl and the solution was washed twice with ethyl acetate, basified with lN-NaOH and then extracted with ether. The ethereal extract was washed with water and then with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain 0.18 g of pale yellow oil. To a solution of the oil in ethanol (4 ml) was added 0.22 g of 18% HCl in EtOH and the mixture was allowed to stand overnight. Precipitated crystals were collected by filtration to obtain 0.11 g of the title compound as white crystals (yield: 27%). 
     mp: 266°-267° C. (dec) 
     EXAMPLE 11 
     (1RS,2SR)-5-Methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol dihydrochloride 
     To a refluxing mixture of 1-(3-aminopropyl)piperidine (284 mg, 2 mmol), sulfurous acid (6% SO 2  aqueous solution) (1.1 ml) and zinc dust (200 mg) in methanol (2.5 ml) was added dropwise over a period of 1 hour a solution of 5-methyl-1-phenylhexane-1,2-dione [bp: 104°-107° C./2 mmHg; prepared from 2-bromo-5-methyl-1-phenylhexan-1-one by a known method {N. Kornblum and H. W. Frazier: J. Am. Chem. Soc., 88, 865 (1966)}] (275 mg, 1.35 mmol) in methanol (1.0 ml). Thereafter, 200 mg of zinc dust and 1.8 ml of sulfurous acid were freshly added to the mixture and the resulting mixture was refluxed for further 2 hours. After cooling, methanol was added to the mixture and insoluble material was removed by filtration. The filtrate was concentrated under reduced pressure and the residue was dissolved in 2N-HCl. The resulting solution was washed three times with ether and then basified with an aqueous sodium hydroxide solution, followed by extraction with ether. The combined ethereal extract was washed twice with water, dried over anhydrous sodium sulfate and evaporated under reduced pressure to give 0.43 g of oily matter. To an ethanol solution of the matter was added 6N-HCl in EtOH (0.64 ml) and the solution was allowed to stand. Precipitated crystals were collected by filtration and washed with ethanol to obtain 170 mg of the title compound as white crystals (yield: 31%). 
     mp: 266°-267° C. (dec) 
     EXAMPLE 12 
     (1RS,2SR)-5-Methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol dihydrochloride 
     A mixture of 1-hydroxy-5-methyl-1-phenylhexan-2-one [bp: 111°-115° C./2 mmHg; prepared by a known method, e.g. D. H. Hey: J. Chem. Soc., 1232 (1930)] (413 mg, 2 mmol), 1-(3-aminopropyl)piperidine (285 mg, 2 mmol) and 0.4 g of 5% Pd/C in methanol (20 ml) was shaken in a shaker bomb at 4 atms of hydrogen for 16 hours at room temperature. The catalysts were removed by filtration and the filtrate was concentrated under reduced pressure. The residue was dissolved in ether and the solution was washed twice with water, dried and then evaporated under reduced pressure. The residue was dissolved in ethanol (12 ml) and to the solution was added 0.7 ml of 6N-HCl in EtOH. The resulting solution was allowed to stand. Precipitated crystals were collected by filtration to obtain 340 mg of the title compound (yield: 42%). 
     mp: 266°-267° C. (dec) 
     EXAMPLE 13 
     (1RS,2SR)-5-Methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol dihydrochloride 
     To a solution of 1-(3-aminopropyl)piperidine (285 mg, 2 mmol) in methanol (6 ml) was added 0.1 ml of 6.8N-HCl in MeOH, 1-hydroxy-5-methyl-1-phenylhexan-2-one (413 mg, 2 mmol) and sodium cyanoborohydride (126 mg, 2 mmol). The reaction mixture was stirred for 19 hours at room temperature. The mixture was concentrated under reduced pressure and to the residue was added lN-HCl and ether. The aqueous layer was separated, basified with a 10% NaOH aqueous solution and then extracted three times with ether. The combined ethereal extract was washed twice with water, dried over anhydrous sodium sulfate and then evaporated under reduced pressure. The residue was dissolved in ethanol (12 ml). To the solution was added 0.70 ml of 6N-HCl in EtOH and the resulting mixture was allowed to stand. Precipitated crystals were collected by filtration to obtain 228 mg of the title compound (yield: 28%). 
     mp: 266°-267° C. (dec) 
     EXAMPLE 14 
     (1RS,2SR)-5-Methyl-1-phenyl-2-(3-piperidinopropylamino)hexan-1-ol dihydrochloride 
     To a solution of sodium hydroxide (1.44 g) in water (6.6 ml) was added a solution of (4RS,5SR)-4-(3-methylbutyl)-5-phenyl-3-(3-piperidinopropyl)-1,3-oxazolidin-2-one (717 mg, 2 mmol) in ethanol (53 ml), the mixture was refluxed for 26 hours and then concentrated under reduced pressure. Water was added to the residue and the mixture was extracted three times with chloroform. The combined extract was dried over anhydrous sodium sulfate and then concentrated under reduced pressure. The residue was dissolved in ethanol (15 ml) and concentrated hydrochloric acid (0.34 ml) was added. Precipitated crystals were collected by filtration, washed first with ethanol and then with hexane to obtain 0.75 g of the title compound as white crystals (yield: 78%). 
     mp: 266°-267° C. (dec) 
     EXAMPLES 15-55 
     The compounds listed in Table 4-A were prepared in a similar manner as described in Examples 1 to 4 and the physical data of these compounds were shown in Table 4-B. 
     
                                           TABLE 4-A                               
__________________________________________________________________________
 ##STR28##                                                                
 Example                                                                  
      Configuration                                                       
             R.sub.1                                                      
                       ##STR29##                                          
                              R.sub.4                                     
                                R.sub.5                                   
                                  X    n                                  
__________________________________________________________________________
15   1RS, 2SR                                                             
            (CH.sub.2).sub.2 CH.sub.3                                     
                       ##STR30##                                          
                             H H H    3                                   
16   1RS, 2RS                                                             
            (CH.sub.2).sub.2 CH.sub.3                                     
                       ##STR31##                                          
                             H H H    3                                   
17   1RS, 2SR                                                             
            (CH.sub.2).sub.3 CH.sub.3                                     
                       ##STR32##                                          
                             H H H    3                                   
18   1RS, 2RS                                                             
            (CH.sub.2).sub.3 CH.sub.3                                     
                       ##STR33##                                          
                             H H H    3                                   
19   1RS, 2SR                                                             
            (CH.sub.2).sub.4 CH.sub.3                                     
                       ##STR34##                                          
                             H H H    3                                   
20   1RS, 2RS                                                             
            (CH.sub.2).sub.4 CH.sub.3                                     
                       ##STR35##                                          
                             H H H    3                                   
21   1RS, 2SR                                                             
            (CH.sub.2).sub.5 CH.sub.3                                     
                       ##STR36##                                          
                             H H H    3                                   
22   1RS, 2SR                                                             
             ##STR37##                                                    
                       ##STR38##                                          
                             H H H    3                                   
23   1RS, 2RS                                                             
             ##STR39##                                                    
                       ##STR40##                                          
                             H H H    3                                   
24   1RS, 2SR                                                             
             ##STR41##                                                    
                       ##STR42##                                          
                             H H H    3                                   
25   1RS, 2RS                                                             
             ##STR43##                                                    
                       ##STR44##                                          
                             H H H    3                                   
26   1R, 2S                                                               
             ##STR45##                                                    
                       ##STR46##                                          
                             H H H    3                                   
27   1S, 2R                                                               
             ##STR47##                                                    
                       ##STR48##                                          
                             H H H    3                                   
28   1S, 2S                                                               
             ##STR49##                                                    
                       ##STR50##                                          
                             H H H    3                                   
29   1R, 2R                                                               
             ##STR51##                                                    
                       ##STR52##                                          
                             H H H    3                                   
30   1RS, 2SR                                                             
             ##STR53##                                                    
                       ##STR54##                                          
                             H H H    3                                   
31   1RS, 2RS                                                             
             ##STR55##                                                    
                       ##STR56##                                          
                             H H H    3                                   
32   1RS, 2SR                                                             
             ##STR57##                                                    
                       ##STR58##                                          
                             H H H    3                                   
33   1RS, 2RS                                                             
             ##STR59##                                                    
                       ##STR60##                                          
                             H H H    3                                   
34   1RS, 2SR                                                             
             ##STR61##                                                    
                       ##STR62##                                          
                             H H H    3                                   
35   1RS, 2RS                                                             
             ##STR63##                                                    
                       ##STR64##                                          
                             H H H    3                                   
36   1RS, 2SR                                                             
             ##STR65##                                                    
                       ##STR66##                                          
                             H H H    2                                   
37   1RS, 2RS                                                             
             ##STR67##                                                    
                       ##STR68##                                          
                             H H H    2                                   
38   1RS, 2SR                                                             
             ##STR69##                                                    
                       ##STR70##                                          
                             H H H    2                                   
39   1RS, 2RS                                                             
             ##STR71##                                                    
                       ##STR72##                                          
                             H H H    2                                   
40   1RS, 2SR                                                             
             ##STR73##                                                    
                       ##STR74##                                          
                             H H H    3                                   
41   1RS, 2SR                                                             
             ##STR75##                                                    
                       ##STR76##                                          
                             H H H    3                                   
42   1RS, 2SR                                                             
             ##STR77##                                                    
                       ##STR78##                                          
                             H H H    3                                   
43   1RS, 2SR                                                             
             ##STR79##                                                    
                       ##STR80##                                          
                             H H H    2                                   
44   1RS, 2SR                                                             
             ##STR81##                                                    
                       ##STR82##                                          
                             H H H    3                                   
45   1RS, 2SR                                                             
             ##STR83##                                                    
                       ##STR84##                                          
                             H H 2-CH.sub.3                               
                                      3                                   
46   1RS, 2SR                                                             
             ##STR85##                                                    
                       ##STR86##                                          
                             H H 3-CH.sub.3                               
                                      3                                   
47   1RS, 2RS                                                             
             ##STR87##                                                    
                       ##STR88##                                          
                             H H 3-CH.sub.3                               
                                      3                                   
48   1RS, 2SR                                                             
             ##STR89##                                                    
                       ##STR90##                                          
                             H H 4-CH.sub.3                               
                                      3                                   
49   1RS, 2RS                                                             
             ##STR91##                                                    
                       ##STR92##                                          
                             H H 4-CH.sub.3                               
                                      3                                   
50   1RS, 2SR                                                             
             ##STR93##                                                    
                       ##STR94##                                          
                             H H 4-OCH.sub.3                              
                                      3                                   
51   1RS, 2SR                                                             
             ##STR95##                                                    
                       ##STR96##                                          
                             H H 4-F  3                                   
52   1RS, 2RS                                                             
             ##STR97##                                                    
                       ##STR98##                                          
                             H H 4-F  3                                   
53   1RS, 2SR                                                             
             ##STR99##                                                    
                       ##STR100##                                         
                             H H 4-Cl 3                                   
54   1RS, 2RS                                                             
             ##STR101##                                                   
                       ##STR102##                                         
                             H H 4-Cl 3                                   
55   1RS, 2SR                                                             
            (CH.sub.2).sub.7 CH.sub.3                                     
                       ##STR103##                                         
                             H H H    3                                   
__________________________________________________________________________
 
    
     
                                           TABLE 4-B                               
__________________________________________________________________________
      mp        IR:ν.sub.max.sup.KBr (cm.sup.-1)                       
                                  NMR(δ:CDCl.sub.3) (free base)     
Example                                                                   
      (dihydrochloride)                                                   
                (dihydrochloride) or [α].sub.D (dihydrochloride)    
__________________________________________________________________________
15    259-261° C. (dec)                                            
                3300, 2940, 2775, 2550, 1585, 1445,                       
                                  0.64-0.92(3H, m, CH.sub.2 C .sub.--H.sub
                                  .3)                                     
      (EtOH)    1285, 1085, 1045, 955, 730, 705                           
                                  0.96-1.88(12H, m, (C .sub.--H.sub.2).sub
                                  .2 CH.sub.3,                            
                                   ##STR104##                             
                                   ##STR105##                             
                                  2.56-2.88(3H, m, C .sub.--HNHC .sub.--H.
                                  sub.2)                                  
                                  4.10(2H, broad S, N .sub.--H, O         
                                  .sub.--H)                               
                                  4.77(1H, d, J=4Hz, C .sub.--HO)         
                                  7.29(5H, m, aromatic protons)           
16    223-227° C. (dec)                                            
                3325, 2930, 2680, 1590, 1450, 1050,                       
                                  0.70-1.00(3H, m, CH.sub.2 C .sub.--H.sub
                                  .3)                                     
      (EtOHEt.sub.2 O)                                                    
                765, 700          1.08-1.84(12H, m, (C .sub.--H.sub.2).sub
                                  .2 CH.sub.3,                            
                                   ##STR106##                             
                                   ##STR107##                             
                                  4.24(1H, d, J=8Hz, C .sub.--HO)         
                                  7.31(5H, m, aromatic protons)           
17    257-258° C. (dec)                                            
                3280, 2940, 2650, 2550, 1590, 1440,                       
                                  0.63-0.96(3H, m, CH.sub.2 C .sub.--H.sub
                                  .3)                                     
      (MeOH)    1280, 1090, 950, 720, 700                                 
                                  0.96-1.86(14H, m, (C .sub.--H.sub.2).sub
                                  .2 CH.sub.3,                            
                                   ##STR108##                             
                                   ##STR109##                             
                                  2.54-2.91(3H, m, C .sub.--HNHC .sub.--H.
                                  sub.2)                                  
                                  3.0-5.3(2H, broad S, N .sub.--H, O      
                                  .sub.--H)                               
                                  4.78(1H, d, J=4Hz, C .sub.--HO)         
                                  7.30(5H, m, aromatic protons)           
18    232-235° C. (dec)                                            
                3290, 2930, 2640, 1585, 1445,                             
                                  0.62-0.99(3H, m, CH.sub.2 C .sub.--H.sub
                                  .3)                                     
      (EtOHEtOAc)                                                         
                1040, 755, 695    0.99-1.80(14H, m, (C .sub.--H.sub.2).sub
                                  .3 CH.sub.3,                            
                                   ##STR110##                             
                                   ##STR111##                             
                                  4.24(1H, d, J=8Hz, C .sub.--HO)         
                                  7.30(5H, m, aromatic protons)           
19    261-262° C. (dec)                                            
                3290, 2940, 2870, 2660, 2550, 1590,                       
                                  0.60-1.85(19H,                          
      (EtOH)    1445, 1290, 1090, 950, 750, 720, 700                      
                                  m, (C .sub.--H.sub.2).sub.4 CH.sub.3,   
                                   ##STR112##                             
                                   ##STR113##                             
                                  2.52-2.87(3H, m, C .sub.--HNHC .sub.--H.
                                  sub.2)                                  
                                  4.77(1H, d, J=4Hz, C .sub.--HO)         
                                  7.29(5H, m, aromatic protons)           
20    238-241° C. (dec)                                            
                3330, 2940, 2690, 2540, 1585, 1445,                       
                                  0.68-1.00(3H, m, CH.sub.2 C .sub.--H.sub
                                  .3)                                     
      (EtOHEtOAc)                                                         
                1050, 760, 700    1.00-1.84(16H, m, (C .sub.--H.sub.2).sub
                                  .4 CH.sub.3,                            
                                   ##STR114##                             
                                   ##STR115##                             
                                  3.20(2H, broad S, O .sub.--H, N         
                                  .sub.--H)                               
                                  4.25(1H, d, J=8Hz, C .sub.--HO)         
                                  7.30(5H, m, aromatic protons)           
21    253-255° C. (dec)                                            
                3280, 2930, 2850, 2670, 2550, 1585,                       
                                  0.68-0.96(3H, m, CH.sub.2 C .sub.--H.sub
                                  .3)                                     
      (EtOH)    1445, 1280, 1040, 955, 700                                
                                  0.96-1.86(20H, m, (C .sub.--H.sub.2).sub
                                  .5 CH.sub.3,                            
                                   ##STR116##                             
                                   ##STR117##                             
                                  2.54-2.92(3H, m, C .sub.--HNHC .sub.--H.
                                  sub.2)                                  
                                  4.78(1H, d, J=4Hz, C .sub.--HO)         
                                  7.29(5H, m, aromatic protons)           
22    210-212° C. (dec)                                            
                3290, 2940, 2670, 2555, 1600, 1445,                       
                                  0.87(6H, d, J=7Hz, CH(C .sub.--H.sub.3).
                                  sub.2)                                  
      (EtOH)    1285, 1125, 1060, 1000, 750, 700                          
                                  1.17-1.92(9H, m, C .sub.--H             
                                  (CH.sub.3).sub.2,                       
                                   ##STR118##                             
                                   ##STR119##                             
                                  4.77(1H, d, J=5Hz, C .sub.--HO)         
                                  7.00-7.45(5H, m, aromatic protons)      
23    238-240° C. (dec)                                            
                3270, 2930, 2650, 2520, 1585, 1450,                       
                                  0.92(3H, d, J=7Hz, CHC  .sub.--H.sub.3) 
                                  O                                       
      (EtOH)    1020, 760, 700    0.96(3H, d, J=7Hz, CHC .sub.--H.sub.3)  
                                  1.17-1.95(9H, m, C .sub.--H(CH.sub.3).su
                                  b.2,                                    
                                   ##STR120##                             
                                   ##STR121##                             
                                  4.32(1H, d, J=6Hz, C .sub.--HO)         
                                  7.00-7.45(5H, m, aromatic protons)      
24    268-270° C. (dec)                                            
                3330, 2945, 2870, 2680, 2560, 1580,                       
                                  0.71(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (EtOH)    1450, 1430, 1400, 1370, 1285, 1145,                       
                                  0.82(3H, d, J=7Hz, CHC .sub.--H.sub.3)  
                1090, 1070, 1040, 965, 955, 755, 705                      
                                  0.86-1.90(11H, m, C .sub.--H.sub.2 C    
                                  .sub.--H(CH.sub.3).sub.2                
                                   ##STR122##                             
                                   ##STR123##                             
                                  2.58-2.92(3H, m, C .sub.--HNHC .sub.--H.
                                  sub.2)                                  
                                  4.10(2H, broad S, N .sub.--H, O         
                                  .sub.--H)                               
                                  4.80(1H, d, J=4Hz, C .sub.--HO)         
                                  7.29(5H, m, aromatic protons)           
25    244-246° C. (dec)                                            
                3360, 3030, 2940, 2870, 2680, 2550,                       
                                  0.76(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (EtOHEtOAc)                                                         
                1575, 1480, 1450, 1430, 1410, 1385,                       
                                  0.86(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
                1365, 1285, 1080, 1070, 1050, 960,                        
                                  1.04- 1.84(11H, m,                      
                950, 760, 700     C .sub.--H.sub.2 C .sub.--H(CH.sub.3).su
                                  b.2,                                    
                                   ##STR124##                             
                                   ##STR125##                             
                                  4.23(1H, d, J=7Hz, C .sub.--HO)         
                                  7.31(5H, m, aromatic protons)           
26    266-267° C. (dec)                                            
                3330, 2940, 2870, 2660, 2540, 1605                        
                                  [α].sub.D -24.9°(C0.62,    
                                  MeOH)                                   
      (EtOH)    1445, 1430, 1400, 1285, 1140, 1090,                       
                1065, 1030, 960, 945, 745, 700                            
27    266-267° C. (dec)                                            
                3330, 2940, 2870, 2660, 2540, 1605                        
                                  [α].sub.D +25.3°(C0.60,    
                                  MeOH)                                   
      (EtOH)    1445, 1430, 1400, 1285, 1140, 1090,                       
                1065, 1030, 960, 945, 745, 700                            
28    234-236° C. (dec)                                            
                3300, 2950, 2700, 2550, 1570, 1450,                       
                                  [α].sub.D +24.3°(C0.60,    
                                  MeOH)                                   
      (EtOHEtOAc)                                                         
                1430, 1390, 1370, 1280, 1200, 1140,                       
                1080, 1045, 950, 760, 700                                 
29    230-232° C. (dec)                                            
                3300, 2950, 2700, 2550, 1570, 1450,                       
                                  [α].sub.D.sup.23 -24.3°(C0.
                                  60, MeOH)                               
      (EtOHEtOAc)                                                         
                1430, 1390, 1370, 1280, 1200, 1140,                       
                1080, 1045, 950, 760, 700                                 
30    240-241° C. (dec)                                            
                3320, 2950, 2680, 1595, 1445, 1090,                       
                                  0.71(3H, d, J=6Hz, CHC  .sub.--H.sub.3) 
                                  O                                       
      (EtOH)    750, 695          0.82(3H, d, J=7Hz, CHC .sub.--H.sub.3)  
                                  0.88-1.96(9H, m, C .sub.--H.sub.2 C     
                                  .sub.--H(CH.sub.3).sub.2,               
                                   ##STR126##                             
                                   ##STR127##                             
                                  3.13(2H, broad S, N .sub.--H, O         
                                  .sub.--H)                               
                                  4.82(1H, d, J=4Hz, C .sub.--HO)         
                                  7.29(5H, m, aromatic protons)           
31    226.5-228.5° C.                                              
                3280, 2960, 2685, 1580, 1450, 1040,                       
                                  0.75(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (dec)     760, 695          0.84(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (EtOHEtOAc)                 0.95-1.96(9H, m, C .sub.--H.sub.2 C     
                                  .sub.--H(CH.sub.3).sub.2,               
                                   ##STR128##                             
                                   ##STR129##                             
                                  3.17(2H, broad S, N .sub.--H, O         
                                  .sub.--H)                               
                                  4.24(1H, d, J=7Hz, C .sub.--HO)         
                                  7.30(5H, m, aromatic protons)           
32    269-270° C. (dec)                                            
                3275, 2940, 2665, 2600, 1590, 1440,                       
                                  0.72(3H, d, J=6Hz, CHC2 C .sub.--H.sub.3
                                  )                                       
      (EtOH)    1255, 1110, 1090, 1045, 755, 705                          
                                  0.83(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
                                  0.88-1.86(5H, m, C .sub.--H.sub.2 C     
                                  .sub.--H(CH.sub.3).sub.2,               
                                   ##STR130##                             
                                   ##STR131##                             
                                  2.63-2.92(3H, m, C .sub.--HNHC .sub.--H.
                                  sub.2)                                  
                                  3.0-4.6(2H, broad S, N .sub.--H, O      
                                  .sub.--H)                               
                                   ##STR132##                             
                                  4.79(1H, d, J=4Hz, C .sub.--HO)         
                                  7.29(5H, m, aromatic protons)           
33    250-252° C. (dec)                                            
                3300, 2950, 2600, 1580, 1450, 1260,                       
                                  0.76(3H, d, J=6Hz, CHC  .sub.--H.sub.3) 
                                  O                                       
      (EtOH)    1110, 1085, 1040, 760, 700                                
                                  0.85(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
                                  1.03-1.80(5H, m, C .sub.--H.sub.2 C     
                                  .sub.--H(CH.sub.3).sub.2,               
                                   ##STR133##                             
                                   ##STR134##                             
                                   ##STR135##                             
                                  4.24(1H, d, J=7Hz, C .sub.--HO)         
                                  2.4-6.4(2H, broad S, N .sub.--H, O      
                                  .sub.--H)                               
                                  7.30(5H, m, aromatic protons)           
34    255-256° C. (dec)                                            
                3300, 2960, 2760, 2645, 2510, 1590,                       
                                  0.64-0.88(6H, m, CH(C .sub.--H.sub.3).su
                                  b.2)                                    
      (EtOH-n-hexane)                                                     
                1455, 1430, 1105, 1065, 1045, 755                         
                                  0.88-2.88(12H, m, C .sub.--H.sub.2 C    
                                  .sub.--H(CH.sub.3).sub.2,               
                700               C .sub.--HNHC .sub.--H.sub.2 C .sub.--H.
                                  sub.2 C .sub.--H.sub.2 N,N .sub.--H, O  
                                  .sub.--H)                               
                                  2.22(6H, S, N(C .sub.--H.sub.3).sub.2)  
                                  4.81(1H, d, J=4Hz, C  .sub.--HO)        
                                  7.29(5H, m, aromatic protons)           
35    243-244° C. (dec)                                            
                3300, 2960, 2670, 1590, 1465, 1450,                       
                                  0.68-0.96(6H, m, CH(C .sub.--H.sub.3).su
                                  b.2)                                    
      (EtOH-n-hexane)                                                     
                1040, 760, 700    1.00-2.80(12H, m, C .sub.--H.sub.2 C    
                                  .sub.--H(CH.sub.3).sub.2, C .sub.--HNHC 
                                  .sub.--H.sub.2 C .sub.--H.sub.2 C       
                                  .sub.--H.sub.2,                         
                                  N .sub.--H, O .sub.--H)                 
                                  2.20(6H, S, N(C .sub.--H.sub.3).sub.2)  
                                  4.24(1H, d, J=7Hz, C .sub.--HO)         
                                  7.30(5H, m, aromatic protons)           
36    234-235° C. (dec)                                            
                3300, 2960, 2720, 2460, 1600, 1460,                       
                                  0.64-0.88(6H, m, CH(C .sub.--H.sub.3).su
                                  b.2)                                    
      (EtOH-n-hexane)                                                     
                1445, 750, 705    0.88-1.76(12H, m,                       
                                   ##STR136##                             
                                  2.10-3.20(11H, m,                       
                                   ##STR137##                             
                                  4.75(1H, d, J=4Hz, C .sub.--HO)         
                                  7.29(5H, m, aromatic protons)           
37    238-239° C. (dec)                                            
                3270, 2955, 2720, 2480, 1560, 1550,                       
                                  0.64-1.00(6H, m, CH(C .sub.--H.sub.3).su
                                  b.2)                                    
      (EtOH-n-hexane)                                                     
                1445, 1385, 1055, 1010, 760, 690                          
                                  1.00-1.76(9H, m,                        
                                   ##STR138##                             
                                  2.10-2.90(9H, m,                        
                                   ##STR139##                             
                                  3.34(2H, broad S, N .sub.--H, O         
                                  .sub.--H)                               
                                  4.24(1H, d, J=7Hz, C .sub.--HO)         
                                  7.30(5H, m, aromatic protons)           
38    236-237° C. (dec)                                            
                3290, 2960, 2650, 2460, 1595, 1460,                       
                                  0.75(3H, d, J=7Hz, CHC .sub.--H.sub.3)  
      (EtOH)    1445, 1090, 1025, 750, 705                                
                                  0.83(3H, d, J=7Hz, CHC .sub.-- H.sub.3) 
                                  O                                       
                                  0.90-2.00(7H, m,                        
                                   ##STR140##                             
                                  2.10-3.00(9H, m,                        
                                   ##STR141##                             
                                  3.0-5.5(2H, broad S, N .sub.--H, O      
                                  .sub.--H)                               
                                  4.75(1H, d, J=4Hz, C .sub.--HO)         
                                  7.30(5H, m, aromatic protons)           
39    201-203° C.                                                  
                3255, 2960, 2600, 1565, 1450, 1060,                       
                                  0.75(3H, d, J=6Hz, CHC .sub.--H.sub.    
                                  3)                                      
      (acetone) 1020, 765, 700    0.84(3H, d, J=7Hz, CHC .sub.--H.sub.3)  
                                  0.93-2.00(7H, m,                        
                                   ##STR142##                             
                                  2.10-2.90(9H, m,                        
                                   ##STR143##                             
                                  3.2-6.4(2H, broad S, N .sub.--H, O      
                                  .sub.--H)                               
                                  4.22(1H, d, J=7Hz, C .sub.--HO)         
                                  7.29(5H, m, aromatic protons)           
40    253-253.5° C. (dec)                                          
                3300, 2950, 2870, 2700, 1590, 1445,                       
                                  0.76(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (EtOH)    1095, 1000, 740, 700                                      
                                  0.77(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
                                  0.96-2.05(11H, m,                       
                                   ##STR144##                             
                                  2.24-2.93(9H, m,                        
                                   ##STR145##                             
                                  4.78(1H, d, J=4Hz, C  .sub.--HO)        
                                  7.30(5H, m, aromatic protons)           
41    264.5-266.5° C.                                              
                3280, 2940, 2870, 2670, 2590, 1590,                       
                                  0.76(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (dec)     1435, 1255, 1110, 1095, 1050, 735                         
                                  0.78(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (EtOH)    700               1.00-1.85(7H, m,                        
                                   ##STR146##                             
                                  2.24-2.88(9H, m,                        
                                   ##STR147##                             
                                  3.69(4H, t, J=5Hz,                      
                                   ##STR148##                             
                                  4.76(1H, d, J=4Hz, C .sub.--HO)         
                                  7.32(5H, m, aromatic protons)           
42    248-249° C. (dec)                                            
                3310, 2950, 2680, 2510, 1590, 1465,                       
                                  0.75(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (EtOH-c.HCl)                                                        
                1445, 1110, 1050, 1030, 740, 700                          
                                  0.77(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
                                  0.96-1.90(7H, m,                        
                                  C .sub.--H.sub.2 C .sub.--H.sub.2 C     
                                  .sub.--H(CH.sub.3).sub.2,               
                                  C .sub.--H.sub.2 CH.sub.2 N(CH.sub.3).su
                                  b.2)                                    
                                  2.10-2.45(2H, m,                        
                                  C .sub.--H.sub.2 N(CH.sub.3).sub.2)     
                                  2.21(6H, S, N(C .sub.--H.sub.3).sub.2)  
                                  2.45-2.87(3H, m, C .sub.--HNHC .sub.--H.
                                  sub.2)                                  
                                  4.77(1H, d, J=4Hz, C .sub.--HO)         
                                  7.29(5H, m, aromatic protons)           
43    228-229° C. (dec)                                            
                3320, 2960, 2870, 2680, 2600, 2480,                       
                                  0.76(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (EtOH-c.HCl)                                                        
                1580, 1445, 1350, 1095, 1020, 740,                        
                                  0.79(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
                700               C .sub.--H.sub.2 C .sub.--H.sub.2 C     
                                  .sub.--H(CH.sub.3).sub.2)               
                                   ##STR149##                             
                                  2.27-2.98(9H, m,                        
                                   ##STR150##                             
                                  4.74(1H, d, J=4Hz, C .sub.--HO)         
                                  7.30(5H, m, aromatic protons)           
44    242.5-244° C.                                                
                3330, 2940, 2880, 2720, 1590, 1450,                       
                                  0.75(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (dec)     1100, 1050, 740, 700                                      
                                  0.77(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (EtOH)                      0.95-1.83(15H, m,                       
                                   ##STR151##                             
                                  2.36-2.88(9H, m,                        
                                   ##STR152##                             
                                  4.77(1H, d, J=4Hz, C .sub.--HO)         
                                  7.30(5H, m, aromatic protons)           
45    236-238° C. (dec)                                            
                3330, 2940, 2670, 2540, 1575, 1440,                       
                                  0.64(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (isoPrOHH.sub.2 O)                                                  
                1280, 1135, 1075, 1035, 950, 745                          
                                  0.79(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
                                  0.86-1.88(11H, m,                       
                                   ##STR153##                             
                                  2.12-2.54(6H, m,                        
                                   ##STR154##                             
                                   ##STR155##                             
                                  2.54-3.04(3H, m, C .sub.--HNHC .sub.--H.
                                  sub.2)                                  
                                  5.05(1H, d, J=3Hz, C .sub.--HO)         
                                  6.92-7.28, 7.40-7.64(4H, m, aromatic    
                                  protons)                                
46    255-256° C. (dec)                                            
                3280, 2930, 2680, 2540, 1600, 1440,                       
                                  0.72(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (90% EtOH)                                                          
                1075, 785, 755, 700                                       
                                  0.82(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
                                  0.86-1.86(11H, m,                       
                                   ##STR156##                             
                                  2.08-2.56(6H, m,                        
                                   ##STR157##                             
                                   ##STR158##                             
                                  2.56-2.96(3H, m, C .sub.--HNHC .sub.--H.
                                  sub.2)                                  
                                  4.77(1H, d, J=4Hz, C .sub.--HO)         
                                  6.84-7.34(4H, m, aromatic protons)      
47    240-243° C. (dec)                                            
                3300, 2940, 2680, 2550, 1590, 1450,                       
                                  0.77(3H, d, J=7Hz, CHC .sub.--H.sub.3)  
      (EtOH)    1045, 780, 705    0.85(3H, d, J=7Hz, CHC .sub.--H.sub.3)  
                                  1.02-1.76(11H, m,                       
                                   ##STR159##                             
                                  2.00-2.84(9H, m,                        
                                   ##STR160##                             
                                   ##STR161##                             
                                  4.19(1H, d, J=7Hz, C .sub.--HO)         
                                  6.88-7.28(4H, m, aromatic protons)      
48    257-259° C. (dec)                                            
                3400, 3340, 2950, 2680, 1430, 1080,                       
                                  0.72(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (EtOHH.sub.2 O)                                                     
                850, 805, 760     0.82(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
                                  0.88-1.84(11H, m,                       
                                   ##STR162##                             
                                  2.10-2.54(6H, m,                        
                                   ##STR163##                             
                                   ##STR164##                             
                                  2.56-2.90(3H, m, C .sub.--HNHC .sub.--H.
                                  sub.2)                                  
                                  4.76(1H, d, J=4Hz, C .sub.--HO)         
                                  6.92-7.32(4H, m, aromatic protons)      
49    243-246° C. (dec)                                            
                3420, 3300, 2940, 2860, 2740, 1605,                       
                                  0.76(3H, d, J=7Hz, CHC .sub.--H.sub.3)  
      (EtOH)    1570, 1445, 1425, 1045, 955, 810                          
                                  0.83(3H, d, J=7Hz, CHC .sub.--H.sub.3)  
                795               1.02-1.84(11H, m,                       
                                   ##STR165##                             
                                  2.07-2.88(9H, m,                        
                                   ##STR166##                             
                                   ##STR167##                             
                                  8.12(2H, broad S, O .sub.--H, N         
                                  .sub.--H)                               
                                  4.19(1H, d, J=7Hz, C .sub.--HO)         
                                  6.92-7.36(4H, m, aromatic protons)      
50    250-251° C. (dec)                                            
                3370, 2930, 2680, 2540, 1605, 1505,                       
                                  0.73(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (90% EtOH)                                                          
                1440, 1250, 1170, 1075, 1030, 805                         
                                  0.83(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
                                  0.86-1.84(11H, m,                       
                                   ##STR168##                             
                                  2.08-2.52(6H, m,                        
                                   ##STR169##                             
                                  2.52-2.88(3H, m, C .sub.--HNHC .sub.--H.
                                  sub.2)                                  
                                   ##STR170##                             
                                  4.74(1H, d, J=4Hz, C .sub.--HO)         
                                  6.66-6.90, 7.02- 7.32(4H, m, aromatic   
                                  protons)                                
51    275-276° C. (dec)                                            
                3400, 3260, 2960, 2680, 2550, 1605,                       
                                  0.71(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (EtOHH.sub.2 O)                                                     
                1505, 1465, 1450, 1430, 1390, 1370,                       
                                  0.82(3H, d, J=6Hz,                      
                1285, 1230, 1160, 1140, 1080, 1040,                       
                                  CHC .sub.--H.sub.3)                     
                1010, 950, 830, 810, 785, 700                             
                                  0.89-1.85(11H, m,                       
                                   ##STR171##                             
                                  2.12-2.57(6H, m,                        
                                   ##STR172##                             
                                  2.5-6.0(2H, broad S, O .sub.--H, N      
                                  .sub.--H)                               
                                  2.57-2.92(3H, m, C .sub.--HNHC .sub.--H.
                                  sub.2)                                  
                                  4.77(1H, d, J=3Hz, C .sub.--HO)         
                                  6.80-7.44(4H, m, aromatic protons)      
52    250-251° C. (dec)                                            
                3300, 2940, 2870, 2640, 2550, 1605,                       
                                  0.75(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (EtOH)    1585, 1450, 1230, 1155, 1050, 835                         
                                  0.85(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
                                  0.92-1.81(11H, m,                       
                                   ##STR173##                             
                                  2.10-2.86(9H, m,                        
                                   ##STR174##                             
                                  4.20(1H, d, J=7Hz, C .sub.--HO)         
                                  6.77-7.44(4H, m, aromatic protons)      
53    278-279° C. (dec)                                            
                3400, 3260, 2940, 2880, 2680, 2550,                       
                                  0.71(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (EtOHH.sub.2 O)                                                     
                1600, 1470, 1445, 1390, 1370, 1140,                       
                                  0.82(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
                1085, 1040, 1015, 960, 850, 800                           
                                  0.84-1.84(11H, m,                       
                                   ##STR175##                             
                                  2.08-2.54(6H, m,                        
                                   ##STR176##                             
                                  2.54-2.91(3H, m, C .sub.--HNHC .sub.--H.
                                  sub.2)                                  
                                  4.77(1H, d, J=4Hz, C .sub.--HO)         
                                  7.27(4H, m, aromatic protons)           
54    252-253° C. (dec)                                            
                3400, 3230, 2950, 2700, 2560, 1600,                       
                                  0.76(3H, d, J=6Hz, CHC .sub.--H.sub.3)  
      (EtOH)    1580, 1475, 1450, 1430, 1390, 1370,                       
                                  0.85(3H, d, J=6Hz,                      
                1200, 1140, 1090, 1060, 1015, 845,                        
                                  CHC .sub.--H.sub.3)                     
                815, 800          0.95-1.77(11H, m,                       
                                   ##STR177##                             
                                  2.10-2.82(9H, m,                        
                                   ##STR178##                             
                                  4.20(1H, d, J=7Hz, C .sub.--HO)         
                                  7.28(4H, m, aromatic protons)           
55    256-257° C. (dec)                                            
                3300, 2930, 2860, 2680, 2550, 1600,                       
                                  0.68-0.98(3H, m,                        
      (EtOH)    1445, 1400, 1350, 1285, 1200, 1135,                       
                                  CH.sub.2 C .sub.--H.sub.3)              
                1090, 1065, 1010, 950, 700                                
                                  0.98-1.84(22H, m,                       
                                   ##STR179##                             
                                  2.12-2.53(6H, m,                        
                                   ##STR180##                             
                                  2.53-2.86(3H, m, C .sub.--HNHC .sub.--H.
                                  sub.2)                                  
                                  4.77(1H, d, J=4Hz, C .sub.--HO)         
                                  7.29(5H, m, aromatic protons)           
__________________________________________________________________________
 
    
     REFERENCE EXAMPLE 1 
     2-(1,3-Dioxo-2-azaindan-2-yl)-4-methyl-1-phenylpentan-1-one 
     Thionyl chloride (34.8 ml, 480 mmol) was added to a mixture of 2-(1,3-dioxo-2-azaindan-2-yl)-4-methylpentanoic acid (83.61 g, 320 mmol) and benzene (320 ml). The resulting mixture was heated under reflux for 2 hours. The solvent and excess thionyl chloride were removed by distillation under reduced pressure, followed by addition of benzene (320 ml). The benzene was removed and fresh benzene (480 ml) was added to form a solution. Anhydrous aluminum chloride (106.7 g, 800 mmol) was added immediately to the solution and the mixture was stirred at room temperature for 3 hours. The reaction mixture was poured into ice-water (700 ml). The aqueous layer was extracted with benzene (200 ml). After being washed first with water and then with an aqueous sodium bicarbonate solution and with brine, the combined organic layer was dried over sodium sulfate and then evaporated under reduced pressure. The residue was treated with ethanol to give crystals. The crystals were dissolved with heating in ethanol (80 ml) and hexane (160 ml) was added. Precipitated crystals were collected by filtration and washed first with a 1:2 mixed solution (240 ml) of ethanol and hexane and then with hexane. The crystals were dried in air to obtain 74.6 g of the title compound as white crystals (yield: 73%). 
     REFERENCE EXAMPLE 2 
     (1RS,2SR)-2-(1,3-Dioxo-2-azaindan-2-yl)-4-methyl-1-phenylpentan-1-ol and (1RS,2RS)-2-(1,3-dioxo-2-azaindan-2-yl)-4-methyl-1-phenylpentan-1-ol 
     Sodium cyanoborohydride (177 g, 2.82 mol) was added over 3 hours to a solution of the compound (141.4 g, 440 mmol) obtained in Reference Example 1 in chloroform (660 ml) and acetic acid (440 ml) while maintaining the reaction temperature below 30° C. The resulting mixture was stirred at room temperature for further 3 hours and then chloroform (1 liter) and water (1.4 liters) were added. The organic layer was separated and washed twice with water, once with an aqueous sodium bicarbonate solution and once with brine. After being dried over sodium sulfate, the organic layer was evaporated under reduced pressure to provide white crystals (142 g). The crystals were then charged on silica gel column chromatography (silica gel: 2.8 kg, solvent: benzene) to obtain first 94.3 g of the (1RS,2SR) isomer as white crystals (yield: 66%) and then 48.4 g of the (1RS,2RS) isomer as white crystals (yield: 34%). 
     REFERENCE EXAMPLE  3 
     (1RS,2RS)-2-(1,3-Dioxo-2-azaindan-2-yl)-4-methyl-1-phenylpentan-1-ol 
     Aluminum isopropoxide (125.6 g, 615 mmol) was added to a suspension of 2-(1,3-dioxo-2-azaindan-2-yl)-4-methyl-1-phenylpentan-1-one (72.3 g, 225 mmol) in isopropanol (1,000 ml). The mixture was heated under reflux for 6.5 hours. The isopropanol was removed by distillation under reduced pressure and to the residue were added ethyl acetate (800 ml) and an aqueous solution of sodium sulfate. The resulting organic layer was decanted and the residue was washed twice with ethyl acetate (200 ml). The combined organic layer was washed with brine. The organic solution was dried and the solvent was removed by distillation under reduced pressure. The residue was recrystallized twice from benzene to obtain 29.3 g of the title compound as white crystals (yield: 40%). 
     REFERENCE EXAMPLE 4 
     (1RS,2SR)-2-Amino-4-methyl-1-phenylpentan-1-ol 
     (1RS,2SR)2-(1,3-Dioxo-2-azaindan-2-yl)-4-methyl-1-phenylpentan-1-ol (80.0 g, 247 mmol) was dissolved with heating (50° C.) in ethanol (800 ml), followed by addition of a mixture of 85% hydrazine hydrate (19.0 ml) in ethanol (200 ml). The resulting mixture was heated under reflux for 3 hours. After ice-cooling, 4N-HCl (700 ml) was added. The mixture was stirred at room temperature for 30 minutes. Insoluble matter was removed by filtration through celite and then washed with 4N-hydrochloric acid (140 ml). The washing was added to the filtrate and the solution was condensed under reduced pressure to remove the ethanol. A 6N-NaOH solution (570 ml) was added with ice-cooling and the mixture was extracted three times with chloroform. After being dried over sodium sulfate, the organic layer was evaporated to obtain 43.2 g of the title compound as white crystals (yield: 91%). 
     REFERENCE EXAMPLE 5 
     4-Methyl-1-(4-methylphenyl)-2-(1,3-dioxo-2-azaindan-2-yl)pentan-1-one 
     2-Bromo-4-methyl-1-(4-methylphenyl)pentan-1-one (13.5 g, 50 mmol) and potassium phthalimide (9.26 g, 50 mmol) were thoroughly mixed and heated at 160° C. for 2 hours. After cooling, to the reaction mixture were added ethyl acetate (100 ml) and water (50 ml). The resulting organic layer was separated and washed with brine. The organic solution was then dried over sodium sulfate and evaporated under reduced pressure. The residue was crystallized by treatment with hexane and the crystals were recrystallized from hexane to obtain 12.2 g of the title compound as white crystals (yield: 73%). 
     REFERENCE EXAMPLE 6 
     (1RS,2SR)-2-Amino-1-phenylheptan-1-ol 
     A mixture of potassium hydroxide(15 g) in water (150 ml) and 2-(1,3-dioxo-2-azaindan-2-yl)-1-phenylheptanone (20.1 g, 60 mmol) was refluxed for 30 minutes. After being cooled, the mixture was acidified with 5% hydrochloric acid. Precipitated white curd was separated by decantation. To the curd was added 225 ml of 5% hydrochloric acid and the mixture was refluxed for 1 hour and then allowed to stand overnight at room temperature. The white precipitate was removed by filtration and the filtrate was concentrated under reduced pressure. The remaining water was removed as an ethanol azeotrope. The residue was treated with hexane to give 14.5 g of 2-amino-1-phenylheptan-1-one hydrochloride (yield : 100%). To a cooled solution of the aminoketone hydrochloride (13.1 g) in methanol (130 ml) was added sodium borohydride (1.53 g, 40 mmol) in limited amounts so as to maintain the reaction temperature below 15 ° C. Thereafter, the mixture was stirred at room temperature for 1 hour and concentrated under reduced pressure. To the residue was added chloroform and water. The mixture was basified with 2N-NaOH and the organic layer was separated. The aqueous layer was extracted twice with chloroform and the combined organic layer was washed with brine, dried over anhydrous sodium sulfate and then evaporated under reduced pressure. The residual white solid was recrystallized from hexane to obtain 7.95 g of the title compound as white crystals (yield : 71%). 
     REFERENCE EXAMPLE 7 
     (1RS,2 RS)-2-Amino-1-phenylheptan-1-ol 
     Acetic anhydride (10 ml) was added to (1RS,2SR)-2-amino-1-phenylheptan-1-ol (4.15 g, 20 mmol) and the mixture was heated at 70° C. for 10 minutes. After being cooled, the reaction mixture was poured into water (100 ml) to which chloroform was added, followed by gradual addition of an aqueous sodium hydroxide solution. The solution thus basified was extracted with chloroform and the extract was dried. The solvent was removed by distillation under reduced pressure to obtain a colorless oil. The oil was ice-cooled, followed by addition of thionyl chloride (20 ml). The mixture was stirred at room temperature for 20 minutes. Water (30 ml) was added in limited amounts with caution and the mixture was heated under reflux for 2 hours. The mixture was cooled and then water was added. Subsequent to washing of the mixture with ether, the resulting aqueous layer was separated and basified with an aqueous sodium hydroxide solution. The mixture was extracted three times with chloroform and dried. The organic solution was evaporated under reduced pressure to give white crystals. The crystals were recrystallized from hexane to obtain 2.73 g of the title compound as white crystals (yield : 66%). 
     REFERENCE EXAMPLE 8 
     (1RS,2SR)-2-Amino-1-(4-methoxyphenyl)-4-methyl-pentan-1-ol 
     2-Hydroxyimino-1-(4-methoxyphenyl)-4-methylpentan-1-one (8.72 g, 37.1 mmol) was dissolved in acetic acid (88 ml). To the solution was added 5% palladium-charcoal (0.87 g) and the reactant was catalytically hydrogenated at normal pressure at 80° C. until hydrogen was absorbed in a molar amount of three times that of the reactant. After removal of the catalyst by filtration, the acetic acid was removed under reduced pressure. The residue was dissolved in lN-HCl (80 ml). The solution was washed twice with ether (30 ml) and the aqueous layer was basified with a 20% aqueous solution of sodium hydroxide. The aqueous layer thus treated was extracted three times with chloroform and the extracts were combined together and then washed once with brine. The resulting extract was dried over sodium sulfate and the solvent was removed by distillation under reduced pressure to give light-yellowish crystals (6.80 g). The crystals were recrystallized from benzene and hexane to obtain 5.24 g of the title compound as white crystals (yield : 63%). 
     Amino alcohols useful as the starting materials for the compounds of the invention were synthesized by the combined use of the methods illustrated in Reference Examples (Method A : Reference Examples 1, 2 and 4, Method B : Reference Examples 1 and 6, Method C : Reference Example 7, Method D : Reference Example 8, Method E : Reference Examples 5, 3 and 4, Method F : Reference Examples 5, 2 and 4). The melting points and synthetic methods of the starting materials thus obtained are give in Table 5. 
     
                                           TABLE 5                                 
__________________________________________________________________________
 ##STR181##                                                               
                 Configu-        Synthetic                                
X     R.sub.1    ration                                                   
                       mp and/or [α].sub.D                          
                                 method                                   
__________________________________________________________________________
H     (CH.sub.2).sub.2 CH.sub.3                                           
                 1RS, 2SR                                                 
                       mp 66-66.5° C.                              
                                 A                                        
H     (CH.sub.2).sub.2 CH.sub.3                                           
                 1RS, 2RS                                                 
                       mp 68.5-69° C.                              
                                 A                                        
H     (CH.sub.2).sub.3 CH.sub.3                                           
                 1RS, 2SR                                                 
                       mp 72.5-74° C.                              
                                 A                                        
H     (CH.sub.2).sub.3 CH.sub.3                                           
                 1RS, 2RS                                                 
                       mp 74-75° C.                                
                                 A                                        
H     (CH.sub.2).sub.4 CH.sub.3                                           
                 1RS, 2SR                                                 
                       mp 67.5-68.5° C.                            
                                 B                                        
H     (CH.sub.2).sub.4 CH.sub.3                                           
                 1RS, 2RS                                                 
                       mp 75-77° C.                                
                                 C                                        
H     (CH.sub.2).sub.5 CH.sub.3                                           
                 1RS, 2SR                                                 
                       mp 79-80° C.                                
                                 A                                        
H     (CH.sub.2).sub.5 CH.sub.3                                           
                 1RS, 2RS                                                 
                       mp 61-62° C.                                
                                 A                                        
H     (CH.sub.2).sub.7 CH.sub.3                                           
                 1RS, 2SR                                                 
                       mp 77-78°  C.                               
                                 D                                        
       ##STR182##                                                         
                 1RS, 2SR                                                 
                       mp 103-104.5° C.                            
                                 A                                        
H                                                                         
       ##STR183##                                                         
                 1RS, 2RS                                                 
                       mp 60-62° C.                                
                                 A                                        
H                                                                         
       ##STR184##                                                         
                 1RS, 2SR                                                 
                       mp 81-83° C.                                
                                 A                                        
H                                                                         
       ##STR185##                                                         
                 1RS, 2RS                                                 
                       mp 72-73° C.                                
                                 A                                        
H                                                                         
       ##STR186##                                                         
                 1R, 2S                                                   
                       mp 70-71° C. [α].sub.D.sup.23         
                       -38.9° (c 1.0, EtOH)                        
                                 A                                        
H                                                                         
       ##STR187##                                                         
                 1S, 2R                                                   
                       mp 70-71° C. [α].sub.D.sup.23         
                       +39.0° (c 1.0, EtOH)                        
                                 A                                        
H                                                                         
       ##STR188##                                                         
                 1S, 2S                                                   
                       mp 65-66° C. [α].sub.D.sup.23         
                       -10.3° (c 1.0, EtOH)                        
                                 A                                        
H                                                                         
       ##STR189##                                                         
                 1R, 2R                                                   
                       mp 65-66° C. [α].sub.D.sup.23         
                       +10.3° (c 1.0, EtOH)                        
                                 A                                        
H                                                                         
       ##STR190##                                                         
                 1RS, 2SR                                                 
                       mp 92-93° C.                                
                                 A                                        
H                                                                         
       ##STR191##                                                         
                 1RS, 2RS                                                 
                       mp 75-76° C.                                
                                 A                                        
2-CH.sub.3                                                                
       ##STR192##                                                         
                 1RS, 2SR                                                 
                       mp 64-65° C.                                
                                 D                                        
3-CH.sub.3                                                                
       ##STR193##                                                         
                 1RS, 2SR                                                 
                       mp 76-78° C.                                
                                 D                                        
3-CH.sub.3                                                                
       ##STR194##                                                         
                 1RS, 2RS                                                 
                       oil       C                                        
4-CH.sub.3                                                                
       ##STR195##                                                         
                 1RS, 2SR                                                 
                       mp 75-76° C.                                
                                 D                                        
4-CH.sub.3                                                                
       ##STR196##                                                         
                 1RS, 2RS                                                 
                       mp 67.5-68.5° C.                            
                                 E                                        
4-OCH.sub. 3                                                              
       ##STR197##                                                         
                 1RS, 2SR                                                 
                       mp 80-82° C.                                
                                 D                                        
4-F                                                                       
       ##STR198##                                                         
                 1RS, 2SR                                                 
                       oil       D                                        
4-F                                                                       
       ##STR199##                                                         
                 1RS, 2RS                                                 
                       oil       E                                        
4-Cl                                                                      
       ##STR200##                                                         
                 1RS, 2SR                                                 
                       mp 95-97° C.                                
                                 F                                        
4-Cl                                                                      
       ##STR201##                                                         
                 1RS, 2RS                                                 
                       mp 68-71° C.                                
                                 F                                        
__________________________________________________________________________
 
    
     REFERENCE EXAMPLE 9 
     (4RS,5SR)-4-(3-Methylbutyl)-5-phenyl-3-(3-piperidinopropyl)-1,3-oxazolidin-2-one 
     A mixture of (4RS, 5SR)-4-(3-methylbutyl)-5-phenyl-1,3-oxazolidin-2-one [mp: 111°-112 ° C.; prepared from (1RS,2SR)-2-amino-5-methyl-1-phenylhexan-1-ol by a known method {M. E. Dyen and D. Swern: Chem. Rev., 67, 197(1967)}] (1.17 g, 5 mmol), 1-(3-chloropropyl)piperidine hydrochloride (1.49 g, 7.5 mmol), anhydrous potassium carbonate powder (2.07 g, 15 mmol) in methyl ethyl ketone (15 ml) was refluxed with stirring for 24 hours. After cooling, insoluble material was removed by filtration and washed with methyl ethyl ketone. The washing and filtrate were combined together and concentrated under reduced pressure The residue was purified by silica gel column chromatography (silica gel:35 g ; eluent: chloroform/methanol) to obtain 1.52 g of the title compound as an oil (yield : 85%).